id	sid	tid	token	lemma	pos
cord-006229-7yoilsho	1	1	key	key	NN
cord-006229-7yoilsho	1	2	:	:	:
cord-006229-7yoilsho	2	1	cord-006229	cord-006229	NNP
cord-006229-7yoilsho	2	2	-	-	HYPH
cord-006229-7yoilsho	2	3	7yoilsho	7yoilsho	CD
cord-006229-7yoilsho	2	4	authors	author	NNS
cord-006229-7yoilsho	2	5	:	:	:
cord-006229-7yoilsho	3	1	nan	nan	NNP
cord-006229-7yoilsho	3	2	title	title	NN
cord-006229-7yoilsho	3	3	:	:	:
cord-006229-7yoilsho	3	4	Abstracts	abstract	NNS
cord-006229-7yoilsho	3	5	of	of	IN
cord-006229-7yoilsho	3	6	the	the	DT
cord-006229-7yoilsho	3	7	82(nd	82(nd	CD
cord-006229-7yoilsho	3	8	)	)	-RRB-
cord-006229-7yoilsho	4	1	Annual	Annual	NNP
cord-006229-7yoilsho	4	2	Meeting	Meeting	NNP
cord-006229-7yoilsho	4	3	of	of	IN
cord-006229-7yoilsho	4	4	the	the	DT
cord-006229-7yoilsho	4	5	German	German	NNP
cord-006229-7yoilsho	4	6	Society	Society	NNP
cord-006229-7yoilsho	4	7	for	for	IN
cord-006229-7yoilsho	4	8	Experimental	Experimental	NNP
cord-006229-7yoilsho	4	9	and	and	CC
cord-006229-7yoilsho	4	10	Clinical	Clinical	NNP
cord-006229-7yoilsho	4	11	Pharmacology	Pharmacology	NNP
cord-006229-7yoilsho	4	12	and	and	CC
cord-006229-7yoilsho	4	13	Toxicology	Toxicology	NNP
cord-006229-7yoilsho	4	14	(	(	-LRB-
cord-006229-7yoilsho	4	15	DGPT	DGPT	NNP
cord-006229-7yoilsho	4	16	)	)	-RRB-
cord-006229-7yoilsho	4	17	and	and	CC
cord-006229-7yoilsho	4	18	the	the	DT
cord-006229-7yoilsho	4	19	18(th	18(th	CD
cord-006229-7yoilsho	4	20	)	)	-RRB-
cord-006229-7yoilsho	5	1	Annual	Annual	NNP
cord-006229-7yoilsho	5	2	Meeting	Meeting	NNP
cord-006229-7yoilsho	5	3	of	of	IN
cord-006229-7yoilsho	5	4	the	the	DT
cord-006229-7yoilsho	5	5	Network	Network	NNP
cord-006229-7yoilsho	5	6	Clinical	Clinical	NNP
cord-006229-7yoilsho	5	7	Pharmacology	Pharmacology	NNP
cord-006229-7yoilsho	5	8	Germany	Germany	NNP
cord-006229-7yoilsho	5	9	(	(	-LRB-
cord-006229-7yoilsho	5	10	VKliPha	VKliPha	NNP
cord-006229-7yoilsho	5	11	)	)	-RRB-
cord-006229-7yoilsho	6	1	in	in	IN
cord-006229-7yoilsho	6	2	cooperation	cooperation	NN
cord-006229-7yoilsho	6	3	with	with	IN
cord-006229-7yoilsho	6	4	the	the	DT
cord-006229-7yoilsho	6	5	Arbeitsgemeinschaft	Arbeitsgemeinschaft	NNP
cord-006229-7yoilsho	6	6	für	für	NNP
cord-006229-7yoilsho	6	7	Angewandte	Angewandte	NNP
cord-006229-7yoilsho	6	8	Humanpharmakologie	Humanpharmakologie	NNP
cord-006229-7yoilsho	6	9	e.	e.	NN
cord-006229-7yoilsho	7	1	V.	V.	NNP
cord-006229-7yoilsho	7	2	(	(	-LRB-
cord-006229-7yoilsho	7	3	AGAH	AGAH	NNP
cord-006229-7yoilsho	7	4	)	)	-RRB-
cord-006229-7yoilsho	7	5	date	date	NN
cord-006229-7yoilsho	7	6	:	:	:
cord-006229-7yoilsho	7	7	2016	2016	CD
cord-006229-7yoilsho	7	8	-	-	HYPH
cord-006229-7yoilsho	7	9	02	02	CD
cord-006229-7yoilsho	7	10	-	-	HYPH
cord-006229-7yoilsho	7	11	06	06	CD
cord-006229-7yoilsho	7	12	journal	journal	NN
cord-006229-7yoilsho	7	13	:	:	:
cord-006229-7yoilsho	8	1	Naunyn	Naunyn	NNP
cord-006229-7yoilsho	8	2	Schmiedebergs	Schmiedebergs	NNP
cord-006229-7yoilsho	8	3	Arch	Arch	NNP
cord-006229-7yoilsho	8	4	Pharmacol	Pharmacol	NNP
cord-006229-7yoilsho	8	5	DOI	DOI	NNP
cord-006229-7yoilsho	8	6	:	:	:
cord-006229-7yoilsho	8	7	10.1007	10.1007	CD
cord-006229-7yoilsho	8	8	/	/	SYM
cord-006229-7yoilsho	8	9	s00210	s00210	NN
cord-006229-7yoilsho	8	10	-	-	HYPH
cord-006229-7yoilsho	8	11	016	016	CD
cord-006229-7yoilsho	8	12	-	-	HYPH
cord-006229-7yoilsho	8	13	1213-y	1213-y	CD
cord-006229-7yoilsho	8	14	sha	sha	NNP
cord-006229-7yoilsho	8	15	:	:	:
cord-006229-7yoilsho	8	16	3c3ec508b6a7c1792bc95e70f28acc47a6b2f82a	3c3ec508b6a7c1792bc95e70f28acc47a6b2f82a	CD
cord-006229-7yoilsho	8	17	doc_id	doc_id	CD
cord-006229-7yoilsho	8	18	:	:	:
cord-006229-7yoilsho	8	19	6229	6229	CD
cord-006229-7yoilsho	8	20	cord_uid	cord_uid	NNS
cord-006229-7yoilsho	8	21	:	:	:
cord-006229-7yoilsho	9	1	7yoilsho	7yoilsho	CC
cord-006229-7yoilsho	9	2	nan	nan	NNP
cord-006229-7yoilsho	10	1	In	in	IN
cord-006229-7yoilsho	10	2	vitro	vitro	FW
cord-006229-7yoilsho	10	3	systems	system	NNS
cord-006229-7yoilsho	10	4	and	and	CC
cord-006229-7yoilsho	10	5	mechanistic	mechanistic	JJ
cord-006229-7yoilsho	10	6	investigations	investigation	NNS
cord-006229-7yoilsho	11	1	I	-PRON-	PRP
cord-006229-7yoilsho	12	1	The	the	DT
cord-006229-7yoilsho	12	2	demand	demand	NN
cord-006229-7yoilsho	12	3	of	of	IN
cord-006229-7yoilsho	12	4	alternative	alternative	JJ
cord-006229-7yoilsho	12	5	test	test	NN
cord-006229-7yoilsho	12	6	systems	system	NNS
cord-006229-7yoilsho	12	7	which	which	WDT
cord-006229-7yoilsho	12	8	closely	closely	RB
cord-006229-7yoilsho	12	9	mirror	mirror	VBP
cord-006229-7yoilsho	12	10	the	the	DT
cord-006229-7yoilsho	12	11	in	in	IN
cord-006229-7yoilsho	12	12	vivo	vivo	NN
cord-006229-7yoilsho	12	13	situation	situation	NN
cord-006229-7yoilsho	12	14	is	be	VBZ
cord-006229-7yoilsho	12	15	one	one	CD
cord-006229-7yoilsho	12	16	of	of	IN
cord-006229-7yoilsho	12	17	the	the	DT
cord-006229-7yoilsho	12	18	main	main	JJ
cord-006229-7yoilsho	12	19	challenges	challenge	NNS
cord-006229-7yoilsho	12	20	in	in	IN
cord-006229-7yoilsho	12	21	modern	modern	JJ
cord-006229-7yoilsho	12	22	toxicity	toxicity	NN
cord-006229-7yoilsho	12	23	testing	testing	NN
cord-006229-7yoilsho	12	24	.	.	.
cord-006229-7yoilsho	13	1	The	the	DT
cord-006229-7yoilsho	13	2	major	major	JJ
cord-006229-7yoilsho	13	3	goal	goal	NN
cord-006229-7yoilsho	13	4	is	be	VBZ
cord-006229-7yoilsho	13	5	the	the	DT
cord-006229-7yoilsho	13	6	development	development	NN
cord-006229-7yoilsho	13	7	of	of	IN
cord-006229-7yoilsho	13	8	in	in	FW
cord-006229-7yoilsho	13	9	vitro	vitro	FW
cord-006229-7yoilsho	13	10	systems	system	NNS
cord-006229-7yoilsho	13	11	that	that	WDT
cord-006229-7yoilsho	13	12	partly	partly	RB
cord-006229-7yoilsho	13	13	display	display	VBP
cord-006229-7yoilsho	13	14	the	the	DT
cord-006229-7yoilsho	13	15	complexity	complexity	NN
cord-006229-7yoilsho	13	16	of	of	IN
cord-006229-7yoilsho	13	17	an	an	DT
cord-006229-7yoilsho	13	18	organism	organism	NN
cord-006229-7yoilsho	13	19	and	and	CC
cord-006229-7yoilsho	13	20	thus	thus	RB
cord-006229-7yoilsho	13	21	may	may	MD
cord-006229-7yoilsho	13	22	mimick	mimick	VB
cord-006229-7yoilsho	13	23	in	in	IN
cord-006229-7yoilsho	13	24	vivo	vivo	NN
cord-006229-7yoilsho	13	25	conditions	condition	NNS
cord-006229-7yoilsho	13	26	.	.	.
cord-006229-7yoilsho	14	1	Despite	despite	IN
cord-006229-7yoilsho	14	2	great	great	JJ
cord-006229-7yoilsho	14	3	efforts	effort	NNS
cord-006229-7yoilsho	14	4	in	in	IN
cord-006229-7yoilsho	14	5	the	the	DT
cord-006229-7yoilsho	14	6	past	past	NN
cord-006229-7yoilsho	14	7	no	no	DT
cord-006229-7yoilsho	14	8	adequate	adequate	NN
cord-006229-7yoilsho	14	9	in	in	IN
cord-006229-7yoilsho	14	10	vitro	vitro	FW
cord-006229-7yoilsho	15	1	systems	system	NNS
cord-006229-7yoilsho	15	2	are	be	VBP
cord-006229-7yoilsho	15	3	available	available	JJ
cord-006229-7yoilsho	15	4	yet	yet	RB
cord-006229-7yoilsho	15	5	.	.	.
cord-006229-7yoilsho	16	1	On	on	IN
cord-006229-7yoilsho	16	2	the	the	DT
cord-006229-7yoilsho	16	3	other	other	JJ
cord-006229-7yoilsho	16	4	hand	hand	NN
cord-006229-7yoilsho	16	5	,	,	,
cord-006229-7yoilsho	16	6	cell	cell	NN
cord-006229-7yoilsho	16	7	cultures	culture	NNS
cord-006229-7yoilsho	16	8	from	from	IN
cord-006229-7yoilsho	16	9	almost	almost	RB
cord-006229-7yoilsho	16	10	every	every	DT
cord-006229-7yoilsho	16	11	organ	organ	NN
cord-006229-7yoilsho	16	12	are	be	VBP
cord-006229-7yoilsho	16	13	easily	easily	RB
cord-006229-7yoilsho	16	14	accessible	accessible	JJ
cord-006229-7yoilsho	16	15	and	and	CC
cord-006229-7yoilsho	16	16	therefore	therefore	RB
cord-006229-7yoilsho	16	17	may	may	MD
cord-006229-7yoilsho	16	18	help	help	VB
cord-006229-7yoilsho	16	19	to	to	TO
cord-006229-7yoilsho	16	20	roughly	roughly	RB
cord-006229-7yoilsho	16	21	assess	assess	VB
cord-006229-7yoilsho	16	22	the	the	DT
cord-006229-7yoilsho	16	23	toxic	toxic	JJ
cord-006229-7yoilsho	16	24	potential	potential	NN
cord-006229-7yoilsho	16	25	of	of	IN
cord-006229-7yoilsho	16	26	substances	substance	NNS
cord-006229-7yoilsho	16	27	at	at	IN
cord-006229-7yoilsho	16	28	target	target	NN
cord-006229-7yoilsho	16	29	structures	structure	NNS
cord-006229-7yoilsho	16	30	.	.	.
cord-006229-7yoilsho	17	1	Nonetheless	nonetheless	RB
cord-006229-7yoilsho	17	2	,	,	,
cord-006229-7yoilsho	17	3	the	the	DT
cord-006229-7yoilsho	17	4	complex	complex	JJ
cord-006229-7yoilsho	17	5	interactions	interaction	NNS
cord-006229-7yoilsho	17	6	which	which	WDT
cord-006229-7yoilsho	17	7	take	take	VBP
cord-006229-7yoilsho	17	8	place	place	NN
cord-006229-7yoilsho	17	9	in	in	IN
cord-006229-7yoilsho	17	10	vivo	vivo	NN
cord-006229-7yoilsho	17	11	can	can	MD
cord-006229-7yoilsho	17	12	not	not	RB
cord-006229-7yoilsho	17	13	be	be	VB
cord-006229-7yoilsho	17	14	addressed	address	VBN
cord-006229-7yoilsho	17	15	in	in	IN
cord-006229-7yoilsho	17	16	single	single	JJ
cord-006229-7yoilsho	17	17	cell	cell	NN
cord-006229-7yoilsho	17	18	cultures	culture	NNS
cord-006229-7yoilsho	17	19	.	.	.
cord-006229-7yoilsho	18	1	In	in	IN
cord-006229-7yoilsho	18	2	the	the	DT
cord-006229-7yoilsho	18	3	liver	liver	NN
cord-006229-7yoilsho	18	4	,	,	,
cord-006229-7yoilsho	18	5	hepatocytes	hepatocyte	NNS
cord-006229-7yoilsho	18	6	comprise	comprise	VBP
cord-006229-7yoilsho	18	7	80	80	CD
cord-006229-7yoilsho	18	8	%	%	NN
cord-006229-7yoilsho	18	9	of	of	IN
cord-006229-7yoilsho	18	10	the	the	DT
cord-006229-7yoilsho	18	11	total	total	JJ
cord-006229-7yoilsho	18	12	liver	liver	NN
cord-006229-7yoilsho	18	13	volume	volume	NN
cord-006229-7yoilsho	18	14	while	while	IN
cord-006229-7yoilsho	18	15	non	non	JJ
cord-006229-7yoilsho	18	16	-	-	JJ
cord-006229-7yoilsho	18	17	parenchymal	parenchymal	JJ
cord-006229-7yoilsho	18	18	cells	cell	NNS
cord-006229-7yoilsho	18	19	-endothelial	-endothelial	JJ
cord-006229-7yoilsho	18	20	cells	cell	NNS
cord-006229-7yoilsho	18	21	,	,	,
cord-006229-7yoilsho	18	22	stellate	stellate	JJ
cord-006229-7yoilsho	18	23	cells	cell	NNS
cord-006229-7yoilsho	18	24	and	and	CC
cord-006229-7yoilsho	18	25	Kupffer	Kupffer	NNP
cord-006229-7yoilsho	18	26	cells	cell	NNS
cord-006229-7yoilsho	19	1	(	(	-LRB-
cord-006229-7yoilsho	19	2	that	that	DT
cord-006229-7yoilsho	19	3	is	is	RB
cord-006229-7yoilsho	19	4	,	,	,
cord-006229-7yoilsho	19	5	liver	liver	NN
cord-006229-7yoilsho	19	6	resident	resident	NN
cord-006229-7yoilsho	19	7	macrophages	macrophage	NNS
cord-006229-7yoilsho	19	8	)	)	-RRB-
cord-006229-7yoilsho	20	1	-contribute	-contribute	VBG
cord-006229-7yoilsho	21	1	only	only	RB
cord-006229-7yoilsho	21	2	6.5	6.5	CD
cord-006229-7yoilsho	21	3	%	%	NN
cord-006229-7yoilsho	21	4	of	of	IN
cord-006229-7yoilsho	21	5	the	the	DT
cord-006229-7yoilsho	21	6	volume	volume	NN
cord-006229-7yoilsho	21	7	,	,	,
cord-006229-7yoilsho	21	8	but	but	CC
cord-006229-7yoilsho	21	9	40	40	CD
cord-006229-7yoilsho	21	10	%	%	NN
cord-006229-7yoilsho	21	11	of	of	IN
cord-006229-7yoilsho	21	12	the	the	DT
cord-006229-7yoilsho	21	13	total	total	JJ
cord-006229-7yoilsho	21	14	cell	cell	NN
cord-006229-7yoilsho	21	15	number	number	NN
cord-006229-7yoilsho	21	16	(	(	-LRB-
cord-006229-7yoilsho	21	17	Kmiec	Kmiec	NNP
cord-006229-7yoilsho	21	18	2001	2001	CD
cord-006229-7yoilsho	21	19	)	)	-RRB-
cord-006229-7yoilsho	21	20	.	.	.
cord-006229-7yoilsho	22	1	It	-PRON-	PRP
cord-006229-7yoilsho	22	2	has	have	VBZ
cord-006229-7yoilsho	22	3	been	be	VBN
cord-006229-7yoilsho	22	4	increasingly	increasingly	RB
cord-006229-7yoilsho	22	5	recognized	recognize	VBN
cord-006229-7yoilsho	22	6	that	that	IN
cord-006229-7yoilsho	22	7	in	in	IN
cord-006229-7yoilsho	22	8	the	the	DT
cord-006229-7yoilsho	22	9	liver	liver	NN
cord-006229-7yoilsho	22	10	neighboring	neighbor	VBG
cord-006229-7yoilsho	22	11	non	non	JJ
cord-006229-7yoilsho	22	12	-	-	JJ
cord-006229-7yoilsho	22	13	parenchymal	parenchymal	JJ
cord-006229-7yoilsho	22	14	cells	cell	NNS
cord-006229-7yoilsho	22	15	release	release	NN
cord-006229-7yoilsho	22	16	molecules	molecule	NNS
cord-006229-7yoilsho	22	17	which	which	WDT
cord-006229-7yoilsho	22	18	contribute	contribute	VBP
cord-006229-7yoilsho	22	19	to	to	IN
cord-006229-7yoilsho	22	20	the	the	DT
cord-006229-7yoilsho	22	21	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	22	22	damage	damage	NN
cord-006229-7yoilsho	22	23	and	and	CC
cord-006229-7yoilsho	22	24	even	even	RB
cord-006229-7yoilsho	22	25	aggravate	aggravate	VB
cord-006229-7yoilsho	22	26	it	-PRON-	PRP
cord-006229-7yoilsho	23	1	(	(	-LRB-
cord-006229-7yoilsho	23	2	Adams	Adams	NNP
cord-006229-7yoilsho	23	3	et	et	NNP
cord-006229-7yoilsho	23	4	al	al	NNP
cord-006229-7yoilsho	23	5	.	.	NNP
cord-006229-7yoilsho	23	6	2010	2010	CD
cord-006229-7yoilsho	23	7	)	)	-RRB-
cord-006229-7yoilsho	23	8	.	.	.
cord-006229-7yoilsho	24	1	In	in	IN
cord-006229-7yoilsho	24	2	our	-PRON-	PRP$
cord-006229-7yoilsho	24	3	project	project	NN
cord-006229-7yoilsho	24	4	a	a	DT
cord-006229-7yoilsho	24	5	human	human	NN
cord-006229-7yoilsho	24	6	in	in	IN
cord-006229-7yoilsho	24	7	vitro	vitro	FW
cord-006229-7yoilsho	24	8	co	co	NN
cord-006229-7yoilsho	24	9	-	-	NN
cord-006229-7yoilsho	24	10	culture	culture	JJ
cord-006229-7yoilsho	24	11	system	system	NN
cord-006229-7yoilsho	24	12	was	be	VBD
cord-006229-7yoilsho	24	13	established	establish	VBN
cord-006229-7yoilsho	24	14	by	by	IN
cord-006229-7yoilsho	24	15	combining	combine	VBG
cord-006229-7yoilsho	24	16	a	a	DT
cord-006229-7yoilsho	24	17	hepatic	hepatic	JJ
cord-006229-7yoilsho	24	18	and	and	CC
cord-006229-7yoilsho	24	19	a	a	DT
cord-006229-7yoilsho	24	20	monocytic	monocytic	JJ
cord-006229-7yoilsho	24	21	cell	cell	NN
cord-006229-7yoilsho	24	22	line	line	NN
cord-006229-7yoilsho	24	23	,	,	,
cord-006229-7yoilsho	24	24	the	the	DT
cord-006229-7yoilsho	24	25	latter	latter	JJ
cord-006229-7yoilsho	24	26	of	of	IN
cord-006229-7yoilsho	24	27	which	which	WDT
cord-006229-7yoilsho	24	28	can	can	MD
cord-006229-7yoilsho	24	29	be	be	VB
cord-006229-7yoilsho	24	30	differentiated	differentiate	VBN
cord-006229-7yoilsho	24	31	to	to	IN
cord-006229-7yoilsho	24	32	a	a	DT
cord-006229-7yoilsho	24	33	macrophage	macrophage	NN
cord-006229-7yoilsho	24	34	-	-	HYPH
cord-006229-7yoilsho	24	35	like	like	JJ
cord-006229-7yoilsho	24	36	phenotype	phenotype	NN
cord-006229-7yoilsho	24	37	.	.	.
cord-006229-7yoilsho	25	1	In	in	IN
cord-006229-7yoilsho	25	2	this	this	DT
cord-006229-7yoilsho	25	3	system	system	NN
cord-006229-7yoilsho	25	4	the	the	DT
cord-006229-7yoilsho	25	5	hepatotoxicty	hepatotoxicty	NN
cord-006229-7yoilsho	25	6	of	of	IN
cord-006229-7yoilsho	25	7	substances	substance	NNS
cord-006229-7yoilsho	25	8	has	have	VBZ
cord-006229-7yoilsho	25	9	been	be	VBN
cord-006229-7yoilsho	25	10	analyzed	analyze	VBN
cord-006229-7yoilsho	25	11	,	,	,
cord-006229-7yoilsho	25	12	and	and	CC
cord-006229-7yoilsho	25	13	the	the	DT
cord-006229-7yoilsho	25	14	results	result	NNS
cord-006229-7yoilsho	25	15	were	be	VBD
cord-006229-7yoilsho	25	16	compared	compare	VBN
cord-006229-7yoilsho	25	17	to	to	IN
cord-006229-7yoilsho	25	18	single	single	JJ
cord-006229-7yoilsho	25	19	cultures	culture	NNS
cord-006229-7yoilsho	25	20	and	and	CC
cord-006229-7yoilsho	25	21	to	to	IN
cord-006229-7yoilsho	25	22	published	publish	VBN
cord-006229-7yoilsho	25	23	data	datum	NNS
cord-006229-7yoilsho	25	24	from	from	IN
cord-006229-7yoilsho	25	25	in	in	IN
cord-006229-7yoilsho	25	26	vivo	vivo	NNP
cord-006229-7yoilsho	25	27	studies	study	NNS
cord-006229-7yoilsho	25	28	.	.	.
cord-006229-7yoilsho	26	1	Using	use	VBG
cord-006229-7yoilsho	26	2	ketoconazole	ketoconazole	NNP
cord-006229-7yoilsho	26	3	,	,	,
cord-006229-7yoilsho	26	4	an	an	DT
cord-006229-7yoilsho	26	5	antifungal	antifungal	NN
cord-006229-7yoilsho	26	6	,	,	,
cord-006229-7yoilsho	26	7	as	as	IN
cord-006229-7yoilsho	26	8	a	a	DT
cord-006229-7yoilsho	26	9	known	know	VBN
cord-006229-7yoilsho	26	10	hepatotoxic	hepatotoxic	JJ
cord-006229-7yoilsho	26	11	substance	substance	NN
cord-006229-7yoilsho	26	12	,	,	,
cord-006229-7yoilsho	26	13	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	26	14	markers	marker	NNS
cord-006229-7yoilsho	26	15	were	be	VBD
cord-006229-7yoilsho	26	16	studied	study	VBN
cord-006229-7yoilsho	26	17	and	and	CC
cord-006229-7yoilsho	26	18	proved	prove	VBN
cord-006229-7yoilsho	26	19	to	to	TO
cord-006229-7yoilsho	26	20	be	be	VB
cord-006229-7yoilsho	26	21	significantly	significantly	RB
cord-006229-7yoilsho	26	22	upregulated	upregulate	VBN
cord-006229-7yoilsho	26	23	only	only	RB
cord-006229-7yoilsho	26	24	in	in	IN
cord-006229-7yoilsho	26	25	coculture	coculture	NN
cord-006229-7yoilsho	26	26	.	.	.
cord-006229-7yoilsho	27	1	Conversely	conversely	RB
cord-006229-7yoilsho	27	2	,	,	,
cord-006229-7yoilsho	27	3	cultures	culture	NNS
cord-006229-7yoilsho	27	4	of	of	IN
cord-006229-7yoilsho	27	5	hepatic	hepatic	JJ
cord-006229-7yoilsho	27	6	cells	cell	NNS
cord-006229-7yoilsho	27	7	only	only	RB
cord-006229-7yoilsho	27	8	did	do	VBD
cord-006229-7yoilsho	27	9	not	not	RB
cord-006229-7yoilsho	27	10	display	display	VB
cord-006229-7yoilsho	27	11	this	this	DT
cord-006229-7yoilsho	27	12	increase	increase	NN
cord-006229-7yoilsho	27	13	in	in	IN
cord-006229-7yoilsho	27	14	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	27	15	markers	marker	NNS
cord-006229-7yoilsho	27	16	.	.	.
cord-006229-7yoilsho	28	1	At	at	IN
cord-006229-7yoilsho	28	2	the	the	DT
cord-006229-7yoilsho	28	3	same	same	JJ
cord-006229-7yoilsho	28	4	time	time	NN
cord-006229-7yoilsho	28	5	,	,	,
cord-006229-7yoilsho	28	6	a	a	DT
cord-006229-7yoilsho	28	7	negative	negative	JJ
cord-006229-7yoilsho	28	8	substance	substance	NN
cord-006229-7yoilsho	28	9	,	,	,
cord-006229-7yoilsho	28	10	caffeine	caffeine	NN
cord-006229-7yoilsho	28	11	,	,	,
cord-006229-7yoilsho	28	12	failed	fail	VBD
cord-006229-7yoilsho	28	13	to	to	TO
cord-006229-7yoilsho	28	14	show	show	VB
cord-006229-7yoilsho	28	15	any	any	DT
cord-006229-7yoilsho	28	16	hepatotoxic	hepatotoxic	JJ
cord-006229-7yoilsho	28	17	potential	potential	NN
cord-006229-7yoilsho	28	18	in	in	IN
cord-006229-7yoilsho	28	19	the	the	DT
cord-006229-7yoilsho	28	20	co	co	NN
cord-006229-7yoilsho	28	21	-	-	NN
cord-006229-7yoilsho	28	22	culture	culture	JJ
cord-006229-7yoilsho	28	23	system	system	NN
cord-006229-7yoilsho	28	24	.	.	.
cord-006229-7yoilsho	29	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	29	2	results	result	NNS
cord-006229-7yoilsho	29	3	demonstrate	demonstrate	VBP
cord-006229-7yoilsho	29	4	that	that	IN
cord-006229-7yoilsho	29	5	this	this	DT
cord-006229-7yoilsho	29	6	novel	novel	NN
cord-006229-7yoilsho	29	7	in	in	IN
cord-006229-7yoilsho	29	8	vitro	vitro	FW
cord-006229-7yoilsho	29	9	co	co	NN
cord-006229-7yoilsho	29	10	-	-	NN
cord-006229-7yoilsho	29	11	culture	culture	JJ
cord-006229-7yoilsho	29	12	model	model	NN
cord-006229-7yoilsho	29	13	represents	represent	VBZ
cord-006229-7yoilsho	29	14	a	a	DT
cord-006229-7yoilsho	29	15	promising	promising	JJ
cord-006229-7yoilsho	29	16	tool	tool	NN
cord-006229-7yoilsho	29	17	to	to	TO
cord-006229-7yoilsho	29	18	evaluate	evaluate	VB
cord-006229-7yoilsho	29	19	the	the	DT
cord-006229-7yoilsho	29	20	hepatotoxic	hepatotoxic	JJ
cord-006229-7yoilsho	29	21	potential	potential	NN
cord-006229-7yoilsho	29	22	of	of	IN
cord-006229-7yoilsho	29	23	substances	substance	NNS
cord-006229-7yoilsho	29	24	.	.	.
cord-006229-7yoilsho	30	1	In	in	IN
cord-006229-7yoilsho	30	2	drug	drug	NN
cord-006229-7yoilsho	30	3	research	research	NN
cord-006229-7yoilsho	30	4	,	,	,
cord-006229-7yoilsho	30	5	it	-PRON-	PRP
cord-006229-7yoilsho	30	6	might	may	MD
cord-006229-7yoilsho	30	7	help	help	VB
cord-006229-7yoilsho	30	8	to	to	TO
cord-006229-7yoilsho	30	9	reduce	reduce	VB
cord-006229-7yoilsho	30	10	animal	animal	NN
cord-006229-7yoilsho	30	11	testing	testing	NN
cord-006229-7yoilsho	30	12	as	as	IN
cord-006229-7yoilsho	30	13	drugs	drug	NNS
cord-006229-7yoilsho	30	14	with	with	IN
cord-006229-7yoilsho	30	15	a	a	DT
cord-006229-7yoilsho	30	16	high	high	JJ
cord-006229-7yoilsho	30	17	DILI	dili	NN
cord-006229-7yoilsho	30	18	potential	potential	NN
cord-006229-7yoilsho	30	19	can	can	MD
cord-006229-7yoilsho	30	20	be	be	VB
cord-006229-7yoilsho	30	21	dropped	drop	VBN
cord-006229-7yoilsho	30	22	early	early	RB
cord-006229-7yoilsho	30	23	in	in	IN
cord-006229-7yoilsho	30	24	the	the	DT
cord-006229-7yoilsho	30	25	development	development	NN
cord-006229-7yoilsho	30	26	phase	phase	NN
cord-006229-7yoilsho	30	27	.	.	.
cord-006229-7yoilsho	31	1	Question	question	NN
cord-006229-7yoilsho	31	2	:	:	:
cord-006229-7yoilsho	31	3	Raman	raman	NN
cord-006229-7yoilsho	31	4	spectroscopy	spectroscopy	NN
cord-006229-7yoilsho	31	5	(	(	-LRB-
cord-006229-7yoilsho	31	6	RS	rs	NN
cord-006229-7yoilsho	31	7	)	)	-RRB-
cord-006229-7yoilsho	31	8	is	be	VBZ
cord-006229-7yoilsho	31	9	a	a	DT
cord-006229-7yoilsho	31	10	highly	highly	RB
cord-006229-7yoilsho	31	11	sensitive	sensitive	JJ
cord-006229-7yoilsho	31	12	analytical	analytical	JJ
cord-006229-7yoilsho	31	13	method	method	NN
cord-006229-7yoilsho	31	14	for	for	IN
cord-006229-7yoilsho	31	15	markerfree	markerfree	NNP
cord-006229-7yoilsho	31	16	and	and	CC
cord-006229-7yoilsho	31	17	non	non	JJ
cord-006229-7yoilsho	31	18	-	-	JJ
cord-006229-7yoilsho	31	19	invasive	invasive	JJ
cord-006229-7yoilsho	31	20	identification	identification	NN
cord-006229-7yoilsho	31	21	and	and	CC
cord-006229-7yoilsho	31	22	characterization	characterization	NN
cord-006229-7yoilsho	31	23	of	of	IN
cord-006229-7yoilsho	31	24	cells	cell	NNS
cord-006229-7yoilsho	31	25	.	.	.
cord-006229-7yoilsho	32	1	Here	here	RB
cord-006229-7yoilsho	32	2	,	,	,
cord-006229-7yoilsho	32	3	we	-PRON-	PRP
cord-006229-7yoilsho	32	4	present	present	VBP
cord-006229-7yoilsho	32	5	RS	rs	NN
cord-006229-7yoilsho	32	6	as	as	IN
cord-006229-7yoilsho	32	7	a	a	DT
cord-006229-7yoilsho	32	8	novel	novel	JJ
cord-006229-7yoilsho	32	9	tool	tool	NN
cord-006229-7yoilsho	32	10	for	for	IN
cord-006229-7yoilsho	32	11	gentle	gentle	JJ
cord-006229-7yoilsho	32	12	yet	yet	CC
cord-006229-7yoilsho	32	13	precise	precise	JJ
cord-006229-7yoilsho	32	14	cell	cell	NN
cord-006229-7yoilsho	32	15	analysis	analysis	NN
cord-006229-7yoilsho	32	16	in	in	IN
cord-006229-7yoilsho	32	17	three	three	CD
cord-006229-7yoilsho	32	18	independent	independent	JJ
cord-006229-7yoilsho	32	19	experiments	experiment	NNS
cord-006229-7yoilsho	32	20	,	,	,
cord-006229-7yoilsho	32	21	focusing	focus	VBG
cord-006229-7yoilsho	32	22	on	on	IN
cord-006229-7yoilsho	32	23	monitoring	monitor	VBG
cord-006229-7yoilsho	32	24	cellular	cellular	JJ
cord-006229-7yoilsho	32	25	reactions	reaction	NNS
cord-006229-7yoilsho	32	26	upon	upon	IN
cord-006229-7yoilsho	32	27	treatment	treatment	NN
cord-006229-7yoilsho	32	28	.	.	.
cord-006229-7yoilsho	33	1	We	-PRON-	PRP
cord-006229-7yoilsho	33	2	could	could	MD
cord-006229-7yoilsho	33	3	provide	provide	VB
cord-006229-7yoilsho	33	4	evidence	evidence	NN
cord-006229-7yoilsho	33	5	that	that	IN
cord-006229-7yoilsho	33	6	RS	rs	NN
cord-006229-7yoilsho	33	7	is	be	VBZ
cord-006229-7yoilsho	33	8	a	a	DT
cord-006229-7yoilsho	33	9	suitable	suitable	JJ
cord-006229-7yoilsho	33	10	tool	tool	NN
cord-006229-7yoilsho	33	11	to	to	TO
cord-006229-7yoilsho	33	12	monitor	monitor	VB
cord-006229-7yoilsho	33	13	cell	cell	NN
cord-006229-7yoilsho	33	14	differentiation	differentiation	NN
cord-006229-7yoilsho	33	15	,	,	,
cord-006229-7yoilsho	33	16	analyze	analyze	VB
cord-006229-7yoilsho	33	17	cell	cell	NN
cord-006229-7yoilsho	33	18	modification	modification	NN
cord-006229-7yoilsho	33	19	and	and	CC
cord-006229-7yoilsho	33	20	study	study	NN
cord-006229-7yoilsho	33	21	cell	cell	NN
cord-006229-7yoilsho	33	22	apoptosis	apoptosis	NN
cord-006229-7yoilsho	33	23	after	after	IN
cord-006229-7yoilsho	33	24	drug	drug	NN
cord-006229-7yoilsho	33	25	application	application	NN
cord-006229-7yoilsho	33	26	.	.	.
cord-006229-7yoilsho	34	1	Methods	method	NNS
cord-006229-7yoilsho	34	2	:	:	:
cord-006229-7yoilsho	34	3	In	in	IN
cord-006229-7yoilsho	34	4	a	a	DT
cord-006229-7yoilsho	34	5	first	first	JJ
cord-006229-7yoilsho	34	6	experiment	experiment	NN
cord-006229-7yoilsho	34	7	,	,	,
cord-006229-7yoilsho	34	8	mesenchymal	mesenchymal	JJ
cord-006229-7yoilsho	34	9	stem	stem	NN
cord-006229-7yoilsho	34	10	cells	cell	NNS
cord-006229-7yoilsho	34	11	(	(	-LRB-
cord-006229-7yoilsho	34	12	MSCs	msc	NNS
cord-006229-7yoilsho	34	13	)	)	-RRB-
cord-006229-7yoilsho	34	14	were	be	VBD
cord-006229-7yoilsho	34	15	treated	treat	VBN
cord-006229-7yoilsho	34	16	with	with	IN
cord-006229-7yoilsho	34	17	erythropoetin	erythropoetin	NNP
cord-006229-7yoilsho	34	18	(	(	-LRB-
cord-006229-7yoilsho	34	19	EPO	EPO	NNP
cord-006229-7yoilsho	34	20	)	)	-RRB-
cord-006229-7yoilsho	34	21	for	for	IN
cord-006229-7yoilsho	34	22	certain	certain	JJ
cord-006229-7yoilsho	34	23	time	time	NN
cord-006229-7yoilsho	34	24	points	point	NNS
cord-006229-7yoilsho	34	25	and	and	CC
cord-006229-7yoilsho	34	26	subsequently	subsequently	RB
cord-006229-7yoilsho	34	27	fixed	fix	VBN
cord-006229-7yoilsho	34	28	with	with	IN
cord-006229-7yoilsho	34	29	paraformaldehyde	paraformaldehyde	NNP
cord-006229-7yoilsho	34	30	(	(	-LRB-
cord-006229-7yoilsho	34	31	PFA	PFA	NNP
cord-006229-7yoilsho	34	32	)	)	-RRB-
cord-006229-7yoilsho	34	33	for	for	IN
cord-006229-7yoilsho	34	34	Raman	Raman	NNP
cord-006229-7yoilsho	34	35	analysis	analysis	NN
cord-006229-7yoilsho	34	36	.	.	.
cord-006229-7yoilsho	35	1	In	in	IN
cord-006229-7yoilsho	35	2	addition	addition	NN
cord-006229-7yoilsho	35	3	,	,	,
cord-006229-7yoilsho	35	4	SKBR3	skbr3	NN
cord-006229-7yoilsho	35	5	breast	breast	NN
cord-006229-7yoilsho	35	6	cancer	cancer	NN
cord-006229-7yoilsho	35	7	cells	cell	NNS
cord-006229-7yoilsho	35	8	were	be	VBD
cord-006229-7yoilsho	35	9	exposed	expose	VBN
cord-006229-7yoilsho	35	10	to	to	IN
cord-006229-7yoilsho	35	11	the	the	DT
cord-006229-7yoilsho	35	12	anti	anti	JJ
cord-006229-7yoilsho	35	13	-	-	JJ
cord-006229-7yoilsho	35	14	cancer	cancer	JJ
cord-006229-7yoilsho	35	15	drug	drug	NN
cord-006229-7yoilsho	35	16	Herceptin	Herceptin	NNP
cord-006229-7yoilsho	35	17	(	(	-LRB-
cord-006229-7yoilsho	35	18	20μg	20μg	NNP
cord-006229-7yoilsho	35	19	/	/	SYM
cord-006229-7yoilsho	35	20	ml	ml	NN
cord-006229-7yoilsho	35	21	)	)	-RRB-
cord-006229-7yoilsho	35	22	.	.	.
cord-006229-7yoilsho	36	1	Cells	cell	NNS
cord-006229-7yoilsho	36	2	were	be	VBD
cord-006229-7yoilsho	36	3	then	then	RB
cord-006229-7yoilsho	36	4	fixed	fix	VBN
cord-006229-7yoilsho	36	5	in	in	IN
cord-006229-7yoilsho	36	6	PFA	PFA	NNP
cord-006229-7yoilsho	36	7	for	for	IN
cord-006229-7yoilsho	36	8	RS	rs	NN
cord-006229-7yoilsho	36	9	.	.	.
cord-006229-7yoilsho	37	1	In	in	IN
cord-006229-7yoilsho	37	2	a	a	DT
cord-006229-7yoilsho	37	3	last	last	JJ
cord-006229-7yoilsho	37	4	experiment	experiment	NN
cord-006229-7yoilsho	37	5	,	,	,
cord-006229-7yoilsho	37	6	MOLM-13	MOLM-13	NNP
cord-006229-7yoilsho	37	7	cells	cell	NNS
cord-006229-7yoilsho	37	8	were	be	VBD
cord-006229-7yoilsho	37	9	separately	separately	RB
cord-006229-7yoilsho	37	10	cultivated	cultivate	VBN
cord-006229-7yoilsho	37	11	in	in	IN
cord-006229-7yoilsho	37	12	microwells	microwell	NNS
cord-006229-7yoilsho	37	13	and	and	CC
cord-006229-7yoilsho	37	14	treated	treat	VBN
cord-006229-7yoilsho	37	15	with	with	IN
cord-006229-7yoilsho	37	16	thymidine	thymidine	NN
cord-006229-7yoilsho	37	17	for	for	IN
cord-006229-7yoilsho	37	18	different	different	JJ
cord-006229-7yoilsho	37	19	time	time	NN
cord-006229-7yoilsho	37	20	points	point	NNS
cord-006229-7yoilsho	37	21	prior	prior	RB
cord-006229-7yoilsho	37	22	to	to	IN
cord-006229-7yoilsho	37	23	Raman	Raman	NNP
cord-006229-7yoilsho	37	24	analysis	analysis	NN
cord-006229-7yoilsho	37	25	.	.	.
cord-006229-7yoilsho	38	1	Results	result	NNS
cord-006229-7yoilsho	38	2	:	:	:
cord-006229-7yoilsho	39	1	Raman	Raman	NNP
cord-006229-7yoilsho	39	2	spectroscopy	spectroscopy	NN
cord-006229-7yoilsho	39	3	was	be	VBD
cord-006229-7yoilsho	39	4	able	able	JJ
cord-006229-7yoilsho	39	5	to	to	TO
cord-006229-7yoilsho	39	6	monitor	monitor	VB
cord-006229-7yoilsho	39	7	differentiation	differentiation	NN
cord-006229-7yoilsho	39	8	of	of	IN
cord-006229-7yoilsho	39	9	EPO	EPO	NNP
cord-006229-7yoilsho	39	10	treated	treat	VBN
cord-006229-7yoilsho	39	11	MSCs	msc	NNS
cord-006229-7yoilsho	39	12	and	and	CC
cord-006229-7yoilsho	39	13	found	find	VBD
cord-006229-7yoilsho	39	14	that	that	IN
cord-006229-7yoilsho	39	15	around	around	IN
cord-006229-7yoilsho	39	16	35	35	CD
cord-006229-7yoilsho	39	17	%	%	NN
cord-006229-7yoilsho	39	18	of	of	IN
cord-006229-7yoilsho	39	19	treated	treat	VBN
cord-006229-7yoilsho	39	20	cells	cell	NNS
cord-006229-7yoilsho	39	21	showed	show	VBD
cord-006229-7yoilsho	39	22	fibroblast	fibroblast	NN
cord-006229-7yoilsho	39	23	like	like	IN
cord-006229-7yoilsho	39	24	Raman	Raman	NNP
cord-006229-7yoilsho	39	25	profiles	profile	NNS
cord-006229-7yoilsho	39	26	.	.	.
cord-006229-7yoilsho	40	1	In	in	IN
cord-006229-7yoilsho	40	2	case	case	NN
cord-006229-7yoilsho	40	3	of	of	IN
cord-006229-7yoilsho	40	4	Herceptin	Herceptin	NNP
cord-006229-7yoilsho	40	5	treated	treat	VBD
cord-006229-7yoilsho	40	6	SKBR3	skbr3	NN
cord-006229-7yoilsho	40	7	cells	cell	NNS
cord-006229-7yoilsho	40	8	,	,	,
cord-006229-7yoilsho	40	9	RS	RS	NNP
cord-006229-7yoilsho	40	10	found	find	VBD
cord-006229-7yoilsho	40	11	internal	internal	JJ
cord-006229-7yoilsho	40	12	changes	change	NNS
cord-006229-7yoilsho	40	13	of	of	IN
cord-006229-7yoilsho	40	14	the	the	DT
cord-006229-7yoilsho	40	15	cell´s	cell´s	NNPS
cord-006229-7yoilsho	40	16	metabolism	metabolism	NN
cord-006229-7yoilsho	40	17	as	as	IN
cord-006229-7yoilsho	40	18	reaction	reaction	NN
cord-006229-7yoilsho	40	19	on	on	IN
cord-006229-7yoilsho	40	20	drug	drug	NN
cord-006229-7yoilsho	40	21	application	application	NN
cord-006229-7yoilsho	40	22	.	.	.
cord-006229-7yoilsho	41	1	Analyzing	analyze	VBG
cord-006229-7yoilsho	41	2	the	the	DT
cord-006229-7yoilsho	41	3	most	most	RBS
cord-006229-7yoilsho	41	4	prominent	prominent	JJ
cord-006229-7yoilsho	41	5	differences	difference	NNS
cord-006229-7yoilsho	41	6	in	in	IN
cord-006229-7yoilsho	41	7	Raman	Raman	NNP
cord-006229-7yoilsho	41	8	spectra	spectrum	NNS
cord-006229-7yoilsho	41	9	revealed	reveal	VBD
cord-006229-7yoilsho	41	10	discrimination	discrimination	NN
cord-006229-7yoilsho	41	11	of	of	IN
cord-006229-7yoilsho	41	12	cells	cell	NNS
cord-006229-7yoilsho	41	13	to	to	TO
cord-006229-7yoilsho	41	14	be	be	VB
cord-006229-7yoilsho	41	15	mainly	mainly	RB
cord-006229-7yoilsho	41	16	due	due	JJ
cord-006229-7yoilsho	41	17	to	to	IN
cord-006229-7yoilsho	41	18	changes	change	NNS
cord-006229-7yoilsho	41	19	in	in	IN
cord-006229-7yoilsho	41	20	amid	amid	IN
cord-006229-7yoilsho	41	21	I	-PRON-	PRP
cord-006229-7yoilsho	41	22	,	,	,
cord-006229-7yoilsho	41	23	lipid	lipid	NN
cord-006229-7yoilsho	41	24	and	and	CC
cord-006229-7yoilsho	41	25	protein	protein	NN
cord-006229-7yoilsho	41	26	content	content	NN
cord-006229-7yoilsho	41	27	.	.	.
cord-006229-7yoilsho	42	1	In	in	IN
cord-006229-7yoilsho	42	2	the	the	DT
cord-006229-7yoilsho	42	3	last	last	JJ
cord-006229-7yoilsho	42	4	experiment	experiment	NN
cord-006229-7yoilsho	42	5	,	,	,
cord-006229-7yoilsho	42	6	RS	RS	NNP
cord-006229-7yoilsho	42	7	was	be	VBD
cord-006229-7yoilsho	42	8	able	able	JJ
cord-006229-7yoilsho	42	9	to	to	TO
cord-006229-7yoilsho	42	10	follow	follow	VB
cord-006229-7yoilsho	42	11	apoptosis	apoptosis	NN
cord-006229-7yoilsho	42	12	of	of	IN
cord-006229-7yoilsho	42	13	MOLM-13	MOLM-13	NNP
cord-006229-7yoilsho	42	14	cells	cell	NNS
cord-006229-7yoilsho	42	15	after	after	IN
cord-006229-7yoilsho	42	16	thymidine	thymidine	NN
cord-006229-7yoilsho	42	17	application	application	NN
cord-006229-7yoilsho	42	18	and	and	CC
cord-006229-7yoilsho	42	19	discriminate	discriminate	VBP
cord-006229-7yoilsho	42	20	early	early	RB
cord-006229-7yoilsho	42	21	from	from	IN
cord-006229-7yoilsho	42	22	late	late	JJ
cord-006229-7yoilsho	42	23	apoptotic	apoptotic	JJ
cord-006229-7yoilsho	42	24	states	state	NNS
cord-006229-7yoilsho	42	25	.	.	.
cord-006229-7yoilsho	43	1	Discussion	discussion	NN
cord-006229-7yoilsho	43	2	:	:	:
cord-006229-7yoilsho	44	1	RS	RS	NNP
cord-006229-7yoilsho	44	2	is	be	VBZ
cord-006229-7yoilsho	44	3	a	a	DT
cord-006229-7yoilsho	44	4	photonic	photonic	JJ
cord-006229-7yoilsho	44	5	marker	marker	NN
cord-006229-7yoilsho	44	6	for	for	IN
cord-006229-7yoilsho	44	7	gentle	gentle	JJ
cord-006229-7yoilsho	44	8	yet	yet	CC
cord-006229-7yoilsho	44	9	highly	highly	RB
cord-006229-7yoilsho	44	10	specific	specific	JJ
cord-006229-7yoilsho	44	11	cell	cell	NN
cord-006229-7yoilsho	44	12	analysis	analysis	NN
cord-006229-7yoilsho	44	13	,	,	,
cord-006229-7yoilsho	44	14	which	which	WDT
cord-006229-7yoilsho	44	15	allows	allow	VBZ
cord-006229-7yoilsho	44	16	monitoring	monitoring	NN
cord-006229-7yoilsho	44	17	of	of	IN
cord-006229-7yoilsho	44	18	single	single	JJ
cord-006229-7yoilsho	44	19	cell	cell	NN
cord-006229-7yoilsho	44	20	reaction	reaction	NN
cord-006229-7yoilsho	44	21	after	after	IN
cord-006229-7yoilsho	44	22	drug	drug	NN
cord-006229-7yoilsho	44	23	treatment	treatment	NN
cord-006229-7yoilsho	44	24	.	.	.
cord-006229-7yoilsho	45	1	Thereby	thereby	RB
cord-006229-7yoilsho	45	2	,	,	,
cord-006229-7yoilsho	45	3	RS	RS	NNP
cord-006229-7yoilsho	45	4	provides	provide	VBZ
cord-006229-7yoilsho	45	5	information	information	NN
cord-006229-7yoilsho	45	6	about	about	IN
cord-006229-7yoilsho	45	7	changes	change	NNS
cord-006229-7yoilsho	45	8	within	within	IN
cord-006229-7yoilsho	45	9	the	the	DT
cord-006229-7yoilsho	45	10	entire	entire	JJ
cord-006229-7yoilsho	45	11	metabolome	metabolome	NN
cord-006229-7yoilsho	45	12	on	on	IN
cord-006229-7yoilsho	45	13	a	a	DT
cord-006229-7yoilsho	45	14	single	single	JJ
cord-006229-7yoilsho	45	15	cell	cell	NN
cord-006229-7yoilsho	45	16	level	level	NN
cord-006229-7yoilsho	45	17	.	.	.
cord-006229-7yoilsho	46	1	Raman	Raman	NNP
cord-006229-7yoilsho	46	2	spectra	spectrum	NNS
cord-006229-7yoilsho	46	3	are	be	VBP
cord-006229-7yoilsho	46	4	as	as	RB
cord-006229-7yoilsho	46	5	characteristic	characteristic	JJ
cord-006229-7yoilsho	46	6	as	as	IN
cord-006229-7yoilsho	46	7	a	a	DT
cord-006229-7yoilsho	46	8	"	"	``
cord-006229-7yoilsho	46	9	fingerprint	fingerprint	NN
cord-006229-7yoilsho	46	10	"	"	''
cord-006229-7yoilsho	46	11	.	.	.
cord-006229-7yoilsho	47	1	RS	RS	NNP
cord-006229-7yoilsho	47	2	works	work	VBZ
cord-006229-7yoilsho	47	3	label	label	NN
cord-006229-7yoilsho	47	4	-	-	HYPH
cord-006229-7yoilsho	47	5	free	free	JJ
cord-006229-7yoilsho	47	6	and	and	CC
cord-006229-7yoilsho	47	7	non	non	JJ
cord-006229-7yoilsho	47	8	-	-	JJ
cord-006229-7yoilsho	47	9	invasive	invasive	JJ
cord-006229-7yoilsho	47	10	and	and	CC
cord-006229-7yoilsho	47	11	thus	thus	RB
cord-006229-7yoilsho	47	12	does	do	VBZ
cord-006229-7yoilsho	47	13	not	not	RB
cord-006229-7yoilsho	47	14	impare	impare	VB
cord-006229-7yoilsho	47	15	cell	cell	NN
cord-006229-7yoilsho	47	16	viability	viability	NN
cord-006229-7yoilsho	47	17	.	.	.
cord-006229-7yoilsho	48	1	This	this	DT
cord-006229-7yoilsho	48	2	allows	allow	VBZ
cord-006229-7yoilsho	48	3	to	to	TO
cord-006229-7yoilsho	48	4	gain	gain	VB
cord-006229-7yoilsho	48	5	new	new	JJ
cord-006229-7yoilsho	48	6	insights	insight	NNS
cord-006229-7yoilsho	48	7	in	in	IN
cord-006229-7yoilsho	48	8	pharmacological	pharmacological	JJ
cord-006229-7yoilsho	48	9	development	development	NN
cord-006229-7yoilsho	48	10	and	and	CC
cord-006229-7yoilsho	48	11	toxicological	toxicological	JJ
cord-006229-7yoilsho	48	12	survey	survey	NN
cord-006229-7yoilsho	48	13	.	.	.
cord-006229-7yoilsho	49	1	Acknowledgement	acknowledgement	NN
cord-006229-7yoilsho	49	2	:	:	:
cord-006229-7yoilsho	50	1	This	this	DT
cord-006229-7yoilsho	50	2	Project	Project	NNP
cord-006229-7yoilsho	50	3	received	receive	VBD
cord-006229-7yoilsho	50	4	funding	funding	NN
cord-006229-7yoilsho	50	5	from	from	IN
cord-006229-7yoilsho	50	6	the	the	DT
cord-006229-7yoilsho	50	7	EU	EU	NNP
cord-006229-7yoilsho	50	8	7th	7th	NNP
cord-006229-7yoilsho	50	9	Health	Health	NNP
cord-006229-7yoilsho	50	10	Program	Program	NNP
cord-006229-7yoilsho	50	11	grant	grant	NN
cord-006229-7yoilsho	50	12	agreement	agreement	NN
cord-006229-7yoilsho	50	13	No	no	DT
cord-006229-7yoilsho	50	14	279288	279288	CD
cord-006229-7yoilsho	50	15	.	.	.
cord-006229-7yoilsho	51	1	Deutsches	Deutsches	NNP
cord-006229-7yoilsho	51	2	Zentrum	Zentrum	NNP
cord-006229-7yoilsho	51	3	für	für	IN
cord-006229-7yoilsho	51	4	Herzinsuffizienz	Herzinsuffizienz	NNP
cord-006229-7yoilsho	51	5	,	,	,
cord-006229-7yoilsho	51	6	Würzburg	Würzburg	NNP
cord-006229-7yoilsho	51	7	,	,	,
cord-006229-7yoilsho	52	1	Germany	Germany	NNP
cord-006229-7yoilsho	52	2	Extracellular	Extracellular	NNP
cord-006229-7yoilsho	52	3	signal	signal	NN
cord-006229-7yoilsho	52	4	-	-	HYPH
cord-006229-7yoilsho	52	5	regulated	regulate	VBN
cord-006229-7yoilsho	52	6	kinases	kinase	NNS
cord-006229-7yoilsho	52	7	1	1	CD
cord-006229-7yoilsho	52	8	and	and	CC
cord-006229-7yoilsho	52	9	2	2	CD
cord-006229-7yoilsho	52	10	(	(	-LRB-
cord-006229-7yoilsho	52	11	ERK1/2	ERK1/2	NNP
cord-006229-7yoilsho	52	12	)	)	-RRB-
cord-006229-7yoilsho	52	13	are	be	VBP
cord-006229-7yoilsho	52	14	essential	essential	JJ
cord-006229-7yoilsho	52	15	for	for	IN
cord-006229-7yoilsho	52	16	the	the	DT
cord-006229-7yoilsho	52	17	regulation	regulation	NN
cord-006229-7yoilsho	52	18	of	of	IN
cord-006229-7yoilsho	52	19	cell	cell	NN
cord-006229-7yoilsho	52	20	growth	growth	NN
cord-006229-7yoilsho	52	21	and	and	CC
cord-006229-7yoilsho	52	22	cell	cell	NN
cord-006229-7yoilsho	52	23	survival	survival	NN
cord-006229-7yoilsho	52	24	and	and	CC
cord-006229-7yoilsho	52	25	their	-PRON-	PRP$
cord-006229-7yoilsho	52	26	kinase	kinase	NN
cord-006229-7yoilsho	52	27	activity	activity	NN
cord-006229-7yoilsho	52	28	is	be	VBZ
cord-006229-7yoilsho	52	29	up	up	RB
cord-006229-7yoilsho	52	30	-	-	HYPH
cord-006229-7yoilsho	52	31	regulated	regulate	VBN
cord-006229-7yoilsho	52	32	for	for	IN
cord-006229-7yoilsho	52	33	example	example	NN
cord-006229-7yoilsho	52	34	in	in	IN
cord-006229-7yoilsho	52	35	different	different	JJ
cord-006229-7yoilsho	52	36	types	type	NNS
cord-006229-7yoilsho	52	37	of	of	IN
cord-006229-7yoilsho	52	38	cancers	cancer	NNS
cord-006229-7yoilsho	52	39	and	and	CC
cord-006229-7yoilsho	52	40	pathological	pathological	JJ
cord-006229-7yoilsho	52	41	cardiac	cardiac	JJ
cord-006229-7yoilsho	52	42	hypertrophy	hypertrophy	NN
cord-006229-7yoilsho	52	43	.	.	.
cord-006229-7yoilsho	53	1	While	while	IN
cord-006229-7yoilsho	53	2	inhibition	inhibition	NN
cord-006229-7yoilsho	53	3	of	of	IN
cord-006229-7yoilsho	53	4	ERK1/2	ERK1/2	NNP
cord-006229-7yoilsho	53	5	activity	activity	NN
cord-006229-7yoilsho	53	6	by	by	IN
cord-006229-7yoilsho	53	7	kinase	kinase	NN
cord-006229-7yoilsho	53	8	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	53	9	prevents	prevent	VBZ
cord-006229-7yoilsho	53	10	tumor	tumor	NN
cord-006229-7yoilsho	53	11	growth	growth	NN
cord-006229-7yoilsho	53	12	,	,	,
cord-006229-7yoilsho	53	13	it	-PRON-	PRP
cord-006229-7yoilsho	53	14	can	can	MD
cord-006229-7yoilsho	53	15	also	also	RB
cord-006229-7yoilsho	53	16	lead	lead	VB
cord-006229-7yoilsho	53	17	to	to	IN
cord-006229-7yoilsho	53	18	exacerbated	exacerbate	VBN
cord-006229-7yoilsho	53	19	cardiomyocyte	cardiomyocyte	NNP
cord-006229-7yoilsho	53	20	death	death	NN
cord-006229-7yoilsho	53	21	and	and	CC
cord-006229-7yoilsho	53	22	impaired	impaired	JJ
cord-006229-7yoilsho	53	23	heart	heart	NN
cord-006229-7yoilsho	53	24	function	function	NN
cord-006229-7yoilsho	53	25	.	.	.
cord-006229-7yoilsho	54	1	Interestingly	interestingly	RB
cord-006229-7yoilsho	54	2	,	,	,
cord-006229-7yoilsho	54	3	we	-PRON-	PRP
cord-006229-7yoilsho	54	4	have	have	VBP
cord-006229-7yoilsho	54	5	previously	previously	RB
cord-006229-7yoilsho	54	6	identified	identify	VBN
cord-006229-7yoilsho	54	7	an	an	DT
cord-006229-7yoilsho	54	8	ERK	ERK	NNP
cord-006229-7yoilsho	54	9	autophosphorylation	autophosphorylation	NN
cord-006229-7yoilsho	54	10	at	at	IN
cord-006229-7yoilsho	54	11	threonine	threonine	NN
cord-006229-7yoilsho	54	12	188	188	CD
cord-006229-7yoilsho	54	13	as	as	IN
cord-006229-7yoilsho	54	14	a	a	DT
cord-006229-7yoilsho	54	15	prerequisite	prerequisite	NN
cord-006229-7yoilsho	54	16	for	for	IN
cord-006229-7yoilsho	54	17	nuclear	nuclear	JJ
cord-006229-7yoilsho	54	18	ERK1/2	ERK1/2	NNP
cord-006229-7yoilsho	54	19	signaling	signal	VBG
cord-006229-7yoilsho	54	20	and	and	CC
cord-006229-7yoilsho	54	21	ERK	ERK	NNP
cord-006229-7yoilsho	54	22	-	-	HYPH
cord-006229-7yoilsho	54	23	mediated	mediate	VBN
cord-006229-7yoilsho	54	24	cardiac	cardiac	JJ
cord-006229-7yoilsho	54	25	hypertrophy	hypertrophy	NN
cord-006229-7yoilsho	54	26	.	.	.
cord-006229-7yoilsho	55	1	Here	here	RB
cord-006229-7yoilsho	55	2	,	,	,
cord-006229-7yoilsho	55	3	we	-PRON-	PRP
cord-006229-7yoilsho	55	4	investigated	investigate	VBD
cord-006229-7yoilsho	55	5	an	an	DT
cord-006229-7yoilsho	55	6	alternative	alternative	JJ
cord-006229-7yoilsho	55	7	strategy	strategy	NN
cord-006229-7yoilsho	55	8	to	to	TO
cord-006229-7yoilsho	55	9	interfere	interfere	VB
cord-006229-7yoilsho	55	10	with	with	IN
cord-006229-7yoilsho	55	11	ERK1/2	ERK1/2	NNP
cord-006229-7yoilsho	55	12	signaling	signal	VBG
cord-006229-7yoilsho	55	13	:	:	:
cord-006229-7yoilsho	56	1	Since	since	IN
cord-006229-7yoilsho	56	2	activation	activation	NN
cord-006229-7yoilsho	56	3	of	of	IN
cord-006229-7yoilsho	56	4	ERK1/2	ERK1/2	NNP
cord-006229-7yoilsho	56	5	triggers	trigger	VBZ
cord-006229-7yoilsho	56	6	ERK	ERK	NNP
cord-006229-7yoilsho	56	7	dimerization	dimerization	NN
cord-006229-7yoilsho	56	8	,	,	,
cord-006229-7yoilsho	56	9	a	a	DT
cord-006229-7yoilsho	56	10	prerequisite	prerequisite	NN
cord-006229-7yoilsho	56	11	for	for	IN
cord-006229-7yoilsho	56	12	ERK	ERK	NNP
cord-006229-7yoilsho	56	13	T188autophosphorylation	T188autophosphorylation	NNP
cord-006229-7yoilsho	56	14	,	,	,
cord-006229-7yoilsho	56	15	we	-PRON-	PRP
cord-006229-7yoilsho	56	16	chose	choose	VBD
cord-006229-7yoilsho	56	17	the	the	DT
cord-006229-7yoilsho	56	18	ERK	ERK	NNP
cord-006229-7yoilsho	56	19	dimer	dimer	NN
cord-006229-7yoilsho	56	20	interface	interface	NN
cord-006229-7yoilsho	56	21	as	as	IN
cord-006229-7yoilsho	56	22	a	a	DT
cord-006229-7yoilsho	56	23	possible	possible	JJ
cord-006229-7yoilsho	56	24	target	target	NN
cord-006229-7yoilsho	56	25	to	to	TO
cord-006229-7yoilsho	56	26	selectively	selectively	RB
cord-006229-7yoilsho	56	27	interfere	interfere	VB
cord-006229-7yoilsho	56	28	with	with	IN
cord-006229-7yoilsho	56	29	ERK	ERK	NNP
cord-006229-7yoilsho	56	30	T188	T188	NNP
cord-006229-7yoilsho	56	31	-phosphorylation	-phosphorylation	NN
cord-006229-7yoilsho	56	32	.	.	.
cord-006229-7yoilsho	57	1	First	first	RB
cord-006229-7yoilsho	57	2	,	,	,
cord-006229-7yoilsho	57	3	we	-PRON-	PRP
cord-006229-7yoilsho	57	4	investigated	investigate	VBD
cord-006229-7yoilsho	57	5	the	the	DT
cord-006229-7yoilsho	57	6	impact	impact	NN
cord-006229-7yoilsho	57	7	of	of	IN
cord-006229-7yoilsho	57	8	monomeric	monomeric	JJ
cord-006229-7yoilsho	57	9	ERK2	ERK2	NNP
cord-006229-7yoilsho	57	10	on	on	IN
cord-006229-7yoilsho	57	11	cardiac	cardiac	JJ
cord-006229-7yoilsho	57	12	function	function	NN
cord-006229-7yoilsho	57	13	.	.	.
cord-006229-7yoilsho	58	1	To	to	TO
cord-006229-7yoilsho	58	2	address	address	VB
cord-006229-7yoilsho	58	3	this	this	DT
cord-006229-7yoilsho	58	4	issue	issue	NN
cord-006229-7yoilsho	58	5	,	,	,
cord-006229-7yoilsho	58	6	we	-PRON-	PRP
cord-006229-7yoilsho	58	7	generated	generate	VBD
cord-006229-7yoilsho	58	8	mice	mouse	NNS
cord-006229-7yoilsho	58	9	with	with	IN
cord-006229-7yoilsho	58	10	cardiac	cardiac	JJ
cord-006229-7yoilsho	58	11	overexpression	overexpression	NN
cord-006229-7yoilsho	58	12	of	of	IN
cord-006229-7yoilsho	58	13	monomeric	monomeric	JJ
cord-006229-7yoilsho	58	14	ERK2	ERK2	NNP
cord-006229-7yoilsho	58	15	∆174	∆174	NNP
cord-006229-7yoilsho	58	16	-	-	HYPH
cord-006229-7yoilsho	58	17	177	177	CD
cord-006229-7yoilsho	58	18	and	and	CC
cord-006229-7yoilsho	58	19	performed	perform	VBN
cord-006229-7yoilsho	58	20	transverse	transverse	JJ
cord-006229-7yoilsho	58	21	aortic	aortic	JJ
cord-006229-7yoilsho	58	22	constriction	constriction	NN
cord-006229-7yoilsho	58	23	(	(	-LRB-
cord-006229-7yoilsho	58	24	TAC	TAC	NNP
cord-006229-7yoilsho	58	25	)	)	-RRB-
cord-006229-7yoilsho	58	26	to	to	TO
cord-006229-7yoilsho	58	27	induce	induce	VB
cord-006229-7yoilsho	58	28	cardiac	cardiac	JJ
cord-006229-7yoilsho	58	29	hypertrophy	hypertrophy	NN
cord-006229-7yoilsho	58	30	.	.	.
cord-006229-7yoilsho	59	1	Compared	compare	VBN
cord-006229-7yoilsho	59	2	to	to	IN
cord-006229-7yoilsho	59	3	wild	wild	JJ
cord-006229-7yoilsho	59	4	-	-	HYPH
cord-006229-7yoilsho	59	5	type	type	NN
cord-006229-7yoilsho	59	6	mice	mice	NN
cord-006229-7yoilsho	59	7	,	,	,
cord-006229-7yoilsho	59	8	ERK2	ERK2	NNP
cord-006229-7yoilsho	59	9	∆174	∆174	NNP
cord-006229-7yoilsho	59	10	-	-	HYPH
cord-006229-7yoilsho	59	11	177	177	CD
cord-006229-7yoilsho	59	12	overexpression	overexpression	NN
cord-006229-7yoilsho	59	13	attenuated	attenuate	VBN
cord-006229-7yoilsho	59	14	TAC	TAC	NNP
cord-006229-7yoilsho	59	15	-	-	HYPH
cord-006229-7yoilsho	59	16	induced	induce	VBN
cord-006229-7yoilsho	59	17	cardiac	cardiac	JJ
cord-006229-7yoilsho	59	18	hypertrophy	hypertrophy	NN
cord-006229-7yoilsho	59	19	,	,	,
cord-006229-7yoilsho	59	20	interstitial	interstitial	JJ
cord-006229-7yoilsho	59	21	fibrosis	fibrosis	NN
cord-006229-7yoilsho	59	22	and	and	CC
cord-006229-7yoilsho	59	23	mRNA	mRNA	NNP
cord-006229-7yoilsho	59	24	expression	expression	NN
cord-006229-7yoilsho	59	25	levels	level	NNS
cord-006229-7yoilsho	59	26	of	of	IN
cord-006229-7yoilsho	59	27	collagen	collagen	NN
cord-006229-7yoilsho	59	28	and	and	CC
cord-006229-7yoilsho	59	29	brain	brain	NN
cord-006229-7yoilsho	59	30	natriuretic	natriuretic	JJ
cord-006229-7yoilsho	59	31	peptide	peptide	NN
cord-006229-7yoilsho	59	32	(	(	-LRB-
cord-006229-7yoilsho	59	33	BNP	BNP	NNP
cord-006229-7yoilsho	59	34	)	)	-RRB-
cord-006229-7yoilsho	59	35	,	,	,
cord-006229-7yoilsho	59	36	while	while	IN
cord-006229-7yoilsho	59	37	cardiomyocyte	cardiomyocyte	NNP
cord-006229-7yoilsho	59	38	survival	survival	NN
cord-006229-7yoilsho	59	39	and	and	CC
cord-006229-7yoilsho	59	40	cardiac	cardiac	JJ
cord-006229-7yoilsho	59	41	function	function	NN
cord-006229-7yoilsho	59	42	were	be	VBD
cord-006229-7yoilsho	59	43	largely	largely	RB
cord-006229-7yoilsho	59	44	preserved	preserve	VBN
cord-006229-7yoilsho	59	45	.	.	.
cord-006229-7yoilsho	60	1	Because	because	IN
cord-006229-7yoilsho	60	2	of	of	IN
cord-006229-7yoilsho	60	3	the	the	DT
cord-006229-7yoilsho	60	4	positive	positive	JJ
cord-006229-7yoilsho	60	5	effects	effect	NNS
cord-006229-7yoilsho	60	6	of	of	IN
cord-006229-7yoilsho	60	7	monomeric	monomeric	JJ
cord-006229-7yoilsho	60	8	ERK	ERK	NNP
cord-006229-7yoilsho	60	9	∆174	∆174	NNP
cord-006229-7yoilsho	60	10	-	-	HYPH
cord-006229-7yoilsho	60	11	177	177	CD
cord-006229-7yoilsho	60	12	in	in	IN
cord-006229-7yoilsho	60	13	the	the	DT
cord-006229-7yoilsho	60	14	heart	heart	NN
cord-006229-7yoilsho	60	15	,	,	,
cord-006229-7yoilsho	60	16	we	-PRON-	PRP
cord-006229-7yoilsho	60	17	designed	design	VBD
cord-006229-7yoilsho	60	18	a	a	DT
cord-006229-7yoilsho	60	19	peptide	peptide	NN
cord-006229-7yoilsho	60	20	to	to	TO
cord-006229-7yoilsho	60	21	interfere	interfere	VB
cord-006229-7yoilsho	60	22	with	with	IN
cord-006229-7yoilsho	60	23	endogenous	endogenous	JJ
cord-006229-7yoilsho	60	24	ERK	ERK	NNP
cord-006229-7yoilsho	60	25	dimerization	dimerization	NN
cord-006229-7yoilsho	60	26	.	.	.
cord-006229-7yoilsho	61	1	Cross	cross	NN
cord-006229-7yoilsho	61	2	-	-	NN
cord-006229-7yoilsho	61	3	linking	linking	NN
cord-006229-7yoilsho	61	4	and	and	CC
cord-006229-7yoilsho	61	5	coimmunoprecipitation	coimmunoprecipitation	NN
cord-006229-7yoilsho	61	6	experiments	experiment	NNS
cord-006229-7yoilsho	61	7	showed	show	VBD
cord-006229-7yoilsho	61	8	that	that	IN
cord-006229-7yoilsho	61	9	the	the	DT
cord-006229-7yoilsho	61	10	peptide	peptide	NN
cord-006229-7yoilsho	61	11	binds	bind	VBZ
cord-006229-7yoilsho	61	12	to	to	IN
cord-006229-7yoilsho	61	13	ERK2	ERK2	NNP
cord-006229-7yoilsho	61	14	and	and	CC
cord-006229-7yoilsho	61	15	prevents	prevent	VBZ
cord-006229-7yoilsho	61	16	its	-PRON-	PRP$
cord-006229-7yoilsho	61	17	dimerization	dimerization	NN
cord-006229-7yoilsho	61	18	.	.	.
cord-006229-7yoilsho	62	1	Moreover	moreover	RB
cord-006229-7yoilsho	62	2	,	,	,
cord-006229-7yoilsho	62	3	the	the	DT
cord-006229-7yoilsho	62	4	peptide	peptide	NN
cord-006229-7yoilsho	62	5	effectively	effectively	RB
cord-006229-7yoilsho	62	6	inhibited	inhibit	VBD
cord-006229-7yoilsho	62	7	ERK	ERK	NNP
cord-006229-7yoilsho	62	8	T188	T188	NNP
cord-006229-7yoilsho	62	9	-phosphorylation	-phosphorylation	NN
cord-006229-7yoilsho	62	10	and	and	CC
cord-006229-7yoilsho	62	11	nuclear	nuclear	JJ
cord-006229-7yoilsho	62	12	translocation	translocation	NN
cord-006229-7yoilsho	62	13	of	of	IN
cord-006229-7yoilsho	62	14	YFP	YFP	NNP
cord-006229-7yoilsho	62	15	-	-	HYPH
cord-006229-7yoilsho	62	16	tagged	tag	VBN
cord-006229-7yoilsho	62	17	wild	wild	JJ
cord-006229-7yoilsho	62	18	-	-	HYPH
cord-006229-7yoilsho	62	19	type	type	NN
cord-006229-7yoilsho	62	20	ERK2	ERK2	NNP
cord-006229-7yoilsho	62	21	after	after	IN
cord-006229-7yoilsho	62	22	phenylephrine	phenylephrine	JJ
cord-006229-7yoilsho	62	23	stimulation	stimulation	NN
cord-006229-7yoilsho	62	24	.	.	.
cord-006229-7yoilsho	63	1	Further	further	RB
cord-006229-7yoilsho	63	2	,	,	,
cord-006229-7yoilsho	63	3	adenoviral	adenoviral	NNP
cord-006229-7yoilsho	63	4	or	or	CC
cord-006229-7yoilsho	63	5	adeno	adeno	NN
cord-006229-7yoilsho	63	6	-	-	HYPH
cord-006229-7yoilsho	63	7	associated	associate	VBN
cord-006229-7yoilsho	63	8	virus	virus	NN
cord-006229-7yoilsho	63	9	serotype	serotype	NN
cord-006229-7yoilsho	63	10	9	9	CD
cord-006229-7yoilsho	63	11	(	(	-LRB-
cord-006229-7yoilsho	63	12	AAV9)-induced	aav9)-induced	JJ
cord-006229-7yoilsho	63	13	overexpression	overexpression	NN
cord-006229-7yoilsho	63	14	of	of	IN
cord-006229-7yoilsho	63	15	the	the	DT
cord-006229-7yoilsho	63	16	peptide	peptide	NN
cord-006229-7yoilsho	63	17	in	in	IN
cord-006229-7yoilsho	63	18	neonatal	neonatal	JJ
cord-006229-7yoilsho	63	19	rat	rat	NN
cord-006229-7yoilsho	63	20	cardiomyocytes	cardiomyocyte	NNS
cord-006229-7yoilsho	63	21	(	(	-LRB-
cord-006229-7yoilsho	63	22	NRCM	NRCM	NNP
cord-006229-7yoilsho	63	23	)	)	-RRB-
cord-006229-7yoilsho	63	24	or	or	CC
cord-006229-7yoilsho	63	25	mouse	mouse	NN
cord-006229-7yoilsho	63	26	hearts	heart	NNS
cord-006229-7yoilsho	63	27	resulted	result	VBD
cord-006229-7yoilsho	63	28	in	in	IN
cord-006229-7yoilsho	63	29	a	a	DT
cord-006229-7yoilsho	63	30	significantly	significantly	RB
cord-006229-7yoilsho	63	31	reduced	reduce	VBN
cord-006229-7yoilsho	63	32	hypertrophic	hypertrophic	JJ
cord-006229-7yoilsho	63	33	response	response	NN
cord-006229-7yoilsho	63	34	to	to	IN
cord-006229-7yoilsho	63	35	phenylephrine	phenylephrine	NNP
cord-006229-7yoilsho	63	36	or	or	CC
cord-006229-7yoilsho	63	37	TAC	TAC	NNP
cord-006229-7yoilsho	63	38	,	,	,
cord-006229-7yoilsho	63	39	Background	background	NN
cord-006229-7yoilsho	63	40	:	:	:
cord-006229-7yoilsho	64	1	G	g	NN
cord-006229-7yoilsho	65	1	i	i	PRP
cord-006229-7yoilsho	65	2	-proteins	-protein	VBZ
cord-006229-7yoilsho	65	3	have	have	VBP
cord-006229-7yoilsho	65	4	been	be	VBN
cord-006229-7yoilsho	65	5	proposed	propose	VBN
cord-006229-7yoilsho	65	6	to	to	TO
cord-006229-7yoilsho	65	7	be	be	VB
cord-006229-7yoilsho	65	8	cardioprotective	cardioprotective	JJ
cord-006229-7yoilsho	65	9	.	.	.
cord-006229-7yoilsho	66	1	It	-PRON-	PRP
cord-006229-7yoilsho	66	2	's	be	VBZ
cord-006229-7yoilsho	66	3	matter	matter	NN
cord-006229-7yoilsho	66	4	of	of	IN
cord-006229-7yoilsho	66	5	debate	debate	NN
cord-006229-7yoilsho	66	6	whether	whether	IN
cord-006229-7yoilsho	66	7	this	this	DT
cord-006229-7yoilsho	66	8	depends	depend	VBZ
cord-006229-7yoilsho	66	9	on	on	IN
cord-006229-7yoilsho	66	10	the	the	DT
cord-006229-7yoilsho	66	11	particular	particular	JJ
cord-006229-7yoilsho	66	12	G	g	NN
cord-006229-7yoilsho	66	13	i	i	PRP
cord-006229-7yoilsho	66	14	isoform	isoform	NN
cord-006229-7yoilsho	66	15	and/or	and/or	CC
cord-006229-7yoilsho	66	16	on	on	IN
cord-006229-7yoilsho	66	17	the	the	DT
cord-006229-7yoilsho	66	18	particular	particular	JJ
cord-006229-7yoilsho	66	19	conditions	condition	NNS
cord-006229-7yoilsho	66	20	(	(	-LRB-
cord-006229-7yoilsho	66	21	e.g.	e.g.	IN
cord-006229-7yoilsho	66	22	cardiac	cardiac	JJ
cord-006229-7yoilsho	66	23	"	"	``
cord-006229-7yoilsho	66	24	stress	stress	NN
cord-006229-7yoilsho	66	25	"	"	''
cord-006229-7yoilsho	66	26	)	)	-RRB-
cord-006229-7yoilsho	66	27	only	only	RB
cord-006229-7yoilsho	66	28	.	.	.
cord-006229-7yoilsho	67	1	In	in	IN
cord-006229-7yoilsho	67	2	our	-PRON-	PRP$
cord-006229-7yoilsho	67	3	study	study	NN
cord-006229-7yoilsho	67	4	we	-PRON-	PRP
cord-006229-7yoilsho	67	5	investigated	investigate	VBD
cord-006229-7yoilsho	67	6	effects	effect	NNS
cord-006229-7yoilsho	67	7	of	of	IN
cord-006229-7yoilsho	67	8	a	a	DT
cord-006229-7yoilsho	67	9	Gα	Gα	NNP
cord-006229-7yoilsho	67	10	i2knockout	i2knockout	NNP
cord-006229-7yoilsho	67	11	on	on	IN
cord-006229-7yoilsho	67	12	cardiac	cardiac	JJ
cord-006229-7yoilsho	67	13	function	function	NN
cord-006229-7yoilsho	67	14	and	and	CC
cord-006229-7yoilsho	67	15	survival	survival	NN
cord-006229-7yoilsho	67	16	in	in	IN
cord-006229-7yoilsho	67	17	a	a	DT
cord-006229-7yoilsho	67	18	murine	murine	JJ
cord-006229-7yoilsho	67	19	heart	heart	NN
cord-006229-7yoilsho	67	20	-	-	HYPH
cord-006229-7yoilsho	67	21	failure	failure	NN
cord-006229-7yoilsho	67	22	model	model	NN
cord-006229-7yoilsho	67	23	of	of	IN
cord-006229-7yoilsho	67	24	cardiac	cardiac	NNP
cord-006229-7yoilsho	67	25	β	β	NNP
cord-006229-7yoilsho	67	26	1adrenoceptor	1adrenoceptor	CD
cord-006229-7yoilsho	67	27	overexpression	overexpression	NN
cord-006229-7yoilsho	67	28	.	.	.
cord-006229-7yoilsho	68	1	Methods	method	NNS
cord-006229-7yoilsho	68	2	and	and	CC
cord-006229-7yoilsho	68	3	results	result	NNS
cord-006229-7yoilsho	68	4	:	:	:
cord-006229-7yoilsho	69	1	β	β	NN
cord-006229-7yoilsho	69	2	1	1	CD
cord-006229-7yoilsho	69	3	-adrenoceptor	-adrenoceptor	HYPH
cord-006229-7yoilsho	69	4	overexpressing	overexpresse	VBG
cord-006229-7yoilsho	69	5	mice	mouse	NNS
cord-006229-7yoilsho	69	6	lacking	lack	VBG
cord-006229-7yoilsho	69	7	Gα	Gα	NNP
cord-006229-7yoilsho	69	8	i2	i2	NNP
cord-006229-7yoilsho	69	9	(	(	-LRB-
cord-006229-7yoilsho	69	10	β	β	NN
cord-006229-7yoilsho	69	11	1	1	CD
cord-006229-7yoilsho	69	12	-tg	-tg	CD
cord-006229-7yoilsho	69	13	/	/	SYM
cord-006229-7yoilsho	69	14	Gα	Gα	NNP
cord-006229-7yoilsho	69	15	i2	i2	NNP
cord-006229-7yoilsho	69	16	-/-	-/-	NNP
cord-006229-7yoilsho	69	17	)	)	-RRB-
cord-006229-7yoilsho	69	18	were	be	VBD
cord-006229-7yoilsho	69	19	compared	compare	VBN
cord-006229-7yoilsho	69	20	to	to	IN
cord-006229-7yoilsho	69	21	wild	wild	JJ
cord-006229-7yoilsho	69	22	-	-	HYPH
cord-006229-7yoilsho	69	23	type	type	NN
cord-006229-7yoilsho	69	24	(	(	-LRB-
cord-006229-7yoilsho	69	25	C57BL/6	C57BL/6	NNP
cord-006229-7yoilsho	69	26	)	)	-RRB-
cord-006229-7yoilsho	69	27	mice	mouse	NNS
cord-006229-7yoilsho	69	28	and	and	CC
cord-006229-7yoilsho	69	29	littermates	littermate	NNS
cord-006229-7yoilsho	69	30	either	either	CC
cord-006229-7yoilsho	69	31	overexpressing	overexpresse	VBG
cord-006229-7yoilsho	69	32	cardiac	cardiac	NN
cord-006229-7yoilsho	69	33	β	β	NNP
cord-006229-7yoilsho	69	34	1	1	CD
cord-006229-7yoilsho	69	35	-adrenoceptors	-adrenoceptors	CD
cord-006229-7yoilsho	70	1	(	(	-LRB-
cord-006229-7yoilsho	70	2	β	β	NN
cord-006229-7yoilsho	70	3	1	1	CD
cord-006229-7yoilsho	70	4	-tg	-tg	CD
cord-006229-7yoilsho	70	5	)	)	-RRB-
cord-006229-7yoilsho	70	6	or	or	CC
cord-006229-7yoilsho	70	7	lacking	lack	VBG
cord-006229-7yoilsho	70	8	Gα	Gα	NNP
cord-006229-7yoilsho	70	9	i2	i2	NNP
cord-006229-7yoilsho	70	10	(	(	-LRB-
cord-006229-7yoilsho	70	11	Gα	Gα	NNP
cord-006229-7yoilsho	70	12	i2	i2	NNP
cord-006229-7yoilsho	70	13	-/-	-/-	NNP
cord-006229-7yoilsho	70	14	)	)	-RRB-
cord-006229-7yoilsho	70	15	.	.	.
cord-006229-7yoilsho	71	1	At	at	IN
cord-006229-7yoilsho	71	2	300	300	CD
cord-006229-7yoilsho	71	3	days	day	NNS
cord-006229-7yoilsho	71	4	of	of	IN
cord-006229-7yoilsho	71	5	age	age	NN
cord-006229-7yoilsho	71	6	mortality	mortality	NN
cord-006229-7yoilsho	71	7	of	of	IN
cord-006229-7yoilsho	71	8	mice	mouse	NNS
cord-006229-7yoilsho	71	9	only	only	RB
cord-006229-7yoilsho	71	10	lacking	lack	VBG
cord-006229-7yoilsho	71	11	Gα	Gα	NNP
cord-006229-7yoilsho	71	12	i2	i2	NNP
cord-006229-7yoilsho	71	13	was	be	VBD
cord-006229-7yoilsho	71	14	higher	high	JJR
cord-006229-7yoilsho	71	15	compared	compare	VBN
cord-006229-7yoilsho	71	16	to	to	IN
cord-006229-7yoilsho	71	17	wild	wild	JJ
cord-006229-7yoilsho	71	18	-	-	HYPH
cord-006229-7yoilsho	71	19	type	type	NN
cord-006229-7yoilsho	71	20	or	or	CC
cord-006229-7yoilsho	71	21	β	β	NN
cord-006229-7yoilsho	71	22	1	1	CD
cord-006229-7yoilsho	71	23	-tg	-tg	NNS
cord-006229-7yoilsho	71	24	,	,	,
cord-006229-7yoilsho	71	25	but	but	CC
cord-006229-7yoilsho	71	26	similar	similar	JJ
cord-006229-7yoilsho	71	27	to	to	IN
cord-006229-7yoilsho	71	28	β	β	XX
cord-006229-7yoilsho	72	1	1tg	1tg	NNP
cord-006229-7yoilsho	72	2	/	/	SYM
cord-006229-7yoilsho	72	3	Gα	Gα	NNP
cord-006229-7yoilsho	72	4	i2	i2	NNP
cord-006229-7yoilsho	72	5	-/mice	-/mice	NNP
cord-006229-7yoilsho	72	6	.	.	.
cord-006229-7yoilsho	73	1	Beyond	beyond	IN
cord-006229-7yoilsho	73	2	300	300	CD
cord-006229-7yoilsho	73	3	days	day	NNS
cord-006229-7yoilsho	73	4	mortality	mortality	NN
cord-006229-7yoilsho	73	5	of	of	IN
cord-006229-7yoilsho	73	6	β	β	NN
cord-006229-7yoilsho	73	7	1	1	CD
cord-006229-7yoilsho	73	8	-tg/	-tg/	NNP
cord-006229-7yoilsho	74	1	Gα	Gα	NNP
cord-006229-7yoilsho	74	2	i2	i2	NNP
cord-006229-7yoilsho	74	3	-/mice	-/mice	NNP
cord-006229-7yoilsho	74	4	was	be	VBD
cord-006229-7yoilsho	74	5	enhanced	enhance	VBN
cord-006229-7yoilsho	74	6	compared	compare	VBN
cord-006229-7yoilsho	74	7	to	to	IN
cord-006229-7yoilsho	74	8	all	all	DT
cord-006229-7yoilsho	74	9	other	other	JJ
cord-006229-7yoilsho	74	10	genotypes	genotype	NNS
cord-006229-7yoilsho	74	11	(	(	-LRB-
cord-006229-7yoilsho	74	12	mean	mean	VBP
cord-006229-7yoilsho	74	13	survival	survival	NN
cord-006229-7yoilsho	74	14	time	time	NN
cord-006229-7yoilsho	74	15	:	:	:
cord-006229-7yoilsho	74	16	363±21	363±21	CD
cord-006229-7yoilsho	74	17	days	day	NNS
cord-006229-7yoilsho	74	18	)	)	-RRB-
cord-006229-7yoilsho	74	19	.	.	.
cord-006229-7yoilsho	75	1	Echocardiography	echocardiography	NN
cord-006229-7yoilsho	75	2	revealed	reveal	VBD
cord-006229-7yoilsho	75	3	similar	similar	JJ
cord-006229-7yoilsho	75	4	cardiac	cardiac	JJ
cord-006229-7yoilsho	75	5	function	function	NN
cord-006229-7yoilsho	75	6	of	of	IN
cord-006229-7yoilsho	75	7	wild	wild	JJ
cord-006229-7yoilsho	75	8	-	-	HYPH
cord-006229-7yoilsho	75	9	type	type	NN
cord-006229-7yoilsho	75	10	,	,	,
cord-006229-7yoilsho	75	11	β	β	NN
cord-006229-7yoilsho	75	12	1	1	CD
cord-006229-7yoilsho	75	13	-tg	-tg	:
cord-006229-7yoilsho	75	14	and	and	CC
cord-006229-7yoilsho	76	1	Gα	Gα	NNP
cord-006229-7yoilsho	76	2	i2	i2	NNP
cord-006229-7yoilsho	76	3	-/mice	-/mice	NNP
cord-006229-7yoilsho	76	4	,	,	,
cord-006229-7yoilsho	76	5	but	but	CC
cord-006229-7yoilsho	76	6	significant	significant	JJ
cord-006229-7yoilsho	76	7	impairment	impairment	NN
cord-006229-7yoilsho	76	8	for	for	IN
cord-006229-7yoilsho	76	9	β	β	NN
cord-006229-7yoilsho	76	10	1	1	CD
cord-006229-7yoilsho	76	11	-tg	-tg	CD
cord-006229-7yoilsho	76	12	/	/	SYM
cord-006229-7yoilsho	76	13	Gα	Gα	NNP
cord-006229-7yoilsho	76	14	i2	i2	NNP
cord-006229-7yoilsho	77	1	-/mice	-/mice	.
cord-006229-7yoilsho	78	1	(	(	-LRB-
cord-006229-7yoilsho	78	2	e.g.	e.g.	IN
cord-006229-7yoilsho	78	3	ejection	ejection	NN
cord-006229-7yoilsho	78	4	fraction	fraction	NN
cord-006229-7yoilsho	78	5	14±2	14±2	CD
cord-006229-7yoilsho	78	6	%	%	NN
cord-006229-7yoilsho	78	7	versus	versus	IN
cord-006229-7yoilsho	78	8	40±4	40±4	CD
cord-006229-7yoilsho	78	9	%	%	NN
cord-006229-7yoilsho	78	10	in	in	IN
cord-006229-7yoilsho	78	11	wild	wild	JJ
cord-006229-7yoilsho	78	12	-	-	HYPH
cord-006229-7yoilsho	78	13	type	type	NN
cord-006229-7yoilsho	78	14	mice	mouse	NNS
cord-006229-7yoilsho	78	15	)	)	-RRB-
cord-006229-7yoilsho	78	16	.	.	.
cord-006229-7yoilsho	79	1	Significantly	significantly	RB
cord-006229-7yoilsho	79	2	increased	increase	VBN
cord-006229-7yoilsho	79	3	ventricle	ventricle	NN
cord-006229-7yoilsho	79	4	-	-	HYPH
cord-006229-7yoilsho	79	5	to	to	IN
cord-006229-7yoilsho	79	6	body	body	NN
cord-006229-7yoilsho	79	7	-	-	HYPH
cord-006229-7yoilsho	79	8	weight	weight	NN
cord-006229-7yoilsho	79	9	ratio	ratio	NN
cord-006229-7yoilsho	79	10	(	(	-LRB-
cord-006229-7yoilsho	79	11	0.71±0.06	0.71±0.06	CD
cord-006229-7yoilsho	79	12	%	%	NN
cord-006229-7yoilsho	79	13	versus	versus	IN
cord-006229-7yoilsho	79	14	0.48±0.02	0.48±0.02	CD
cord-006229-7yoilsho	79	15	%	%	NN
cord-006229-7yoilsho	79	16	in	in	IN
cord-006229-7yoilsho	79	17	wild	wild	JJ
cord-006229-7yoilsho	79	18	types	type	NNS
cord-006229-7yoilsho	79	19	)	)	-RRB-
cord-006229-7yoilsho	79	20	,	,	,
cord-006229-7yoilsho	79	21	left	leave	VBN
cord-006229-7yoilsho	79	22	-	-	HYPH
cord-006229-7yoilsho	79	23	ventricular	ventricular	JJ
cord-006229-7yoilsho	79	24	size	size	NN
cord-006229-7yoilsho	79	25	(	(	-LRB-
cord-006229-7yoilsho	79	26	length	length	NN
cord-006229-7yoilsho	79	27	0.82±0.04	0.82±0.04	CD
cord-006229-7yoilsho	79	28	cm	cm	NNS
cord-006229-7yoilsho	79	29	versus	versus	IN
cord-006229-7yoilsho	79	30	0.66±0.03	0.66±0.03	CD
cord-006229-7yoilsho	79	31	cm	cm	NNS
cord-006229-7yoilsho	79	32	in	in	IN
cord-006229-7yoilsho	79	33	wild	wild	JJ
cord-006229-7yoilsho	79	34	types	type	NNS
cord-006229-7yoilsho	79	35	)	)	-RRB-
cord-006229-7yoilsho	79	36	and	and	CC
cord-006229-7yoilsho	79	37	ANP	ANP	NNP
cord-006229-7yoilsho	79	38	and	and	CC
cord-006229-7yoilsho	79	39	BNP	BNP	NNP
cord-006229-7yoilsho	79	40	expression	expression	NN
cord-006229-7yoilsho	79	41	(	(	-LRB-
cord-006229-7yoilsho	79	42	mRNA	mrna	NN
cord-006229-7yoilsho	79	43	:	:	:
cord-006229-7yoilsho	79	44	2819	2819	CD
cord-006229-7yoilsho	79	45	%	%	NN
cord-006229-7yoilsho	79	46	and	and	CC
cord-006229-7yoilsho	79	47	495	495	CD
cord-006229-7yoilsho	79	48	%	%	NN
cord-006229-7yoilsho	79	49	of	of	IN
cord-006229-7yoilsho	79	50	wild	wild	JJ
cord-006229-7yoilsho	79	51	type	type	NN
cord-006229-7yoilsho	79	52	,	,	,
cord-006229-7yoilsho	79	53	respectively	respectively	RB
cord-006229-7yoilsho	79	54	)	)	-RRB-
cord-006229-7yoilsho	79	55	clearly	clearly	RB
cord-006229-7yoilsho	79	56	indicated	indicate	VBD
cord-006229-7yoilsho	79	57	hypertrophy	hypertrophy	NN
cord-006229-7yoilsho	79	58	.	.	.
cord-006229-7yoilsho	80	1	Gα	Gα	NNP
cord-006229-7yoilsho	80	2	i3	i3	NNP
cord-006229-7yoilsho	80	3	was	be	VBD
cord-006229-7yoilsho	80	4	significantly	significantly	RB
cord-006229-7yoilsho	80	5	upregulated	upregulate	VBN
cord-006229-7yoilsho	80	6	in	in	IN
cord-006229-7yoilsho	80	7	Gα	Gα	NNP
cord-006229-7yoilsho	80	8	i2	i2	NNP
cord-006229-7yoilsho	80	9	-knockouts	-knockout	NNS
cord-006229-7yoilsho	80	10	(	(	-LRB-
cord-006229-7yoilsho	80	11	protein	protein	NN
cord-006229-7yoilsho	80	12	compared	compare	VBN
cord-006229-7yoilsho	80	13	to	to	IN
cord-006229-7yoilsho	80	14	wild	wild	JJ
cord-006229-7yoilsho	80	15	-	-	HYPH
cord-006229-7yoilsho	80	16	type	type	NN
cord-006229-7yoilsho	80	17	mice	mouse	NNS
cord-006229-7yoilsho	80	18	:	:	:
cord-006229-7yoilsho	80	19	340±90	340±90	CD
cord-006229-7yoilsho	80	20	%	%	NN
cord-006229-7yoilsho	80	21	in	in	IN
cord-006229-7yoilsho	80	22	Gα	Gα	NNP
cord-006229-7yoilsho	80	23	i2	i2	NNP
cord-006229-7yoilsho	80	24	-/and	-/and	CC
cord-006229-7yoilsho	80	25	394±80	394±80	CD
cord-006229-7yoilsho	80	26	%	%	NN
cord-006229-7yoilsho	80	27	in	in	IN
cord-006229-7yoilsho	80	28	β	β	NNP
cord-006229-7yoilsho	80	29	1	1	CD
cord-006229-7yoilsho	80	30	-tg	-tg	CD
cord-006229-7yoilsho	80	31	/	/	SYM
cord-006229-7yoilsho	80	32	Gα	Gα	NNP
cord-006229-7yoilsho	80	33	i2	i2	NNP
cord-006229-7yoilsho	80	34	-/-	-/-	NNP
cord-006229-7yoilsho	80	35	,	,	,
cord-006229-7yoilsho	80	36	respectively	respectively	RB
cord-006229-7yoilsho	80	37	)	)	-RRB-
cord-006229-7yoilsho	80	38	.	.	.
cord-006229-7yoilsho	81	1	Radioligand	radioligand	JJ
cord-006229-7yoilsho	81	2	binding	bind	VBG
cord-006229-7yoilsho	81	3	experiments	experiment	NNS
cord-006229-7yoilsho	81	4	confirmed	confirm	VBD
cord-006229-7yoilsho	81	5	cardiac	cardiac	JJ
cord-006229-7yoilsho	81	6	overexpression	overexpression	NN
cord-006229-7yoilsho	81	7	of	of	IN
cord-006229-7yoilsho	81	8	β	β	NNP
cord-006229-7yoilsho	81	9	1adrenoceptors	1adrenoceptors	CD
cord-006229-7yoilsho	81	10	in	in	IN
cord-006229-7yoilsho	81	11	β	β	NNP
cord-006229-7yoilsho	81	12	1	1	CD
cord-006229-7yoilsho	81	13	-tg	-tg	:
cord-006229-7yoilsho	81	14	mice	mouse	NNS
cord-006229-7yoilsho	81	15	.	.	.
cord-006229-7yoilsho	82	1	Of	of	IN
cord-006229-7yoilsho	82	2	note	note	NN
cord-006229-7yoilsho	82	3	,	,	,
cord-006229-7yoilsho	82	4	overexpression	overexpression	NN
cord-006229-7yoilsho	82	5	levels	level	NNS
cord-006229-7yoilsho	82	6	differed	differ	VBD
cord-006229-7yoilsho	82	7	depending	depend	VBG
cord-006229-7yoilsho	82	8	on	on	IN
cord-006229-7yoilsho	82	9	the	the	DT
cord-006229-7yoilsho	82	10	particular	particular	JJ
cord-006229-7yoilsho	82	11	wild	wild	JJ
cord-006229-7yoilsho	82	12	-	-	HYPH
cord-006229-7yoilsho	82	13	type	type	NN
cord-006229-7yoilsho	82	14	background	background	NN
cord-006229-7yoilsho	82	15	.	.	.
cord-006229-7yoilsho	83	1	On	on	IN
cord-006229-7yoilsho	83	2	an	an	DT
cord-006229-7yoilsho	83	3	FVB	FVB	NNP
cord-006229-7yoilsho	83	4	/	/	SYM
cord-006229-7yoilsho	83	5	N	n	CD
cord-006229-7yoilsho	83	6	background	background	NN
cord-006229-7yoilsho	83	7	we	-PRON-	PRP
cord-006229-7yoilsho	83	8	found	find	VBD
cord-006229-7yoilsho	83	9	the	the	DT
cord-006229-7yoilsho	83	10	overexpression	overexpression	NN
cord-006229-7yoilsho	83	11	level	level	NN
cord-006229-7yoilsho	83	12	to	to	TO
cord-006229-7yoilsho	83	13	be	be	VB
cord-006229-7yoilsho	83	14	more	more	JJR
cord-006229-7yoilsho	83	15	than	than	IN
cord-006229-7yoilsho	83	16	2-fold	2-fold	CD
cord-006229-7yoilsho	83	17	higher	high	JJR
cord-006229-7yoilsho	84	1	(	(	-LRB-
cord-006229-7yoilsho	84	2	B	B	NNP
cord-006229-7yoilsho	84	3	max	max	NN
cord-006229-7yoilsho	84	4	:	:	:
cord-006229-7yoilsho	85	1	1425	1425	CD
cord-006229-7yoilsho	85	2	±	±	CD
cord-006229-7yoilsho	85	3	68	68	CD
cord-006229-7yoilsho	85	4	fmol	fmol	NNP
cord-006229-7yoilsho	85	5	/	/	SYM
cord-006229-7yoilsho	85	6	mg	mg	NN
cord-006229-7yoilsho	85	7	)	)	-RRB-
cord-006229-7yoilsho	86	1	than	than	IN
cord-006229-7yoilsho	86	2	on	on	IN
cord-006229-7yoilsho	87	1	the	the	DT
cord-006229-7yoilsho	87	2	otherwise	otherwise	RB
cord-006229-7yoilsho	87	3	used	use	VBN
cord-006229-7yoilsho	87	4	C57BL/6	C57BL/6	NNP
cord-006229-7yoilsho	87	5	background	background	NN
cord-006229-7yoilsho	87	6	.	.	.
cord-006229-7yoilsho	88	1	Accordingly	accordingly	RB
cord-006229-7yoilsho	88	2	,	,	,
cord-006229-7yoilsho	88	3	FVB	FVB	NNP
cord-006229-7yoilsho	88	4	/	/	SYM
cord-006229-7yoilsho	88	5	N	N	NNP
cord-006229-7yoilsho	88	6	-	-	HYPH
cord-006229-7yoilsho	88	7	based	base	VBN
cord-006229-7yoilsho	88	8	β	β	NN
cord-006229-7yoilsho	88	9	1	1	CD
cord-006229-7yoilsho	88	10	-tg	-tg	:
cord-006229-7yoilsho	88	11	mice	mouse	NNS
cord-006229-7yoilsho	88	12	showed	show	VBD
cord-006229-7yoilsho	88	13	a	a	DT
cord-006229-7yoilsho	88	14	significantly	significantly	RB
cord-006229-7yoilsho	88	15	impaired	impair	VBN
cord-006229-7yoilsho	88	16	cardiac	cardiac	JJ
cord-006229-7yoilsho	88	17	function	function	NN
cord-006229-7yoilsho	88	18	at	at	IN
cord-006229-7yoilsho	88	19	an	an	DT
cord-006229-7yoilsho	88	20	age	age	NN
cord-006229-7yoilsho	88	21	of	of	IN
cord-006229-7yoilsho	88	22	300d	300d	NNS
cord-006229-7yoilsho	88	23	while	while	IN
cord-006229-7yoilsho	88	24	C57BL/6-based	c57bl/6-base	VBD
cord-006229-7yoilsho	88	25	β	β	NNP
cord-006229-7yoilsho	88	26	1	1	CD
cord-006229-7yoilsho	88	27	-tg	-tg	:
cord-006229-7yoilsho	88	28	mice	mouse	NNS
cord-006229-7yoilsho	88	29	did	do	VBD
cord-006229-7yoilsho	88	30	not	not	RB
cord-006229-7yoilsho	88	31	.	.	.
cord-006229-7yoilsho	89	1	Conclusions	conclusion	NNS
cord-006229-7yoilsho	89	2	:	:	:
cord-006229-7yoilsho	90	1	Gα	Gα	NNP
cord-006229-7yoilsho	90	2	i2	i2	NNP
cord-006229-7yoilsho	90	3	-deficiency	-deficiency	XX
cord-006229-7yoilsho	90	4	combined	combine	VBN
cord-006229-7yoilsho	90	5	with	with	IN
cord-006229-7yoilsho	90	6	cardiac	cardiac	NN
cord-006229-7yoilsho	90	7	β	β	NN
cord-006229-7yoilsho	91	1	1	1	LS
cord-006229-7yoilsho	91	2	-adrenoceptor	-adrenoceptor	NN
cord-006229-7yoilsho	91	3	overexpression	overexpression	NN
cord-006229-7yoilsho	91	4	strongly	strongly	RB
cord-006229-7yoilsho	91	5	impaired	impair	VBD
cord-006229-7yoilsho	91	6	survival	survival	NN
cord-006229-7yoilsho	91	7	and	and	CC
cord-006229-7yoilsho	91	8	cardiac	cardiac	JJ
cord-006229-7yoilsho	91	9	function	function	NN
cord-006229-7yoilsho	91	10	.	.	.
cord-006229-7yoilsho	92	1	On	on	IN
cord-006229-7yoilsho	92	2	a	a	DT
cord-006229-7yoilsho	92	3	C57BL/6	C57BL/6	NNP
cord-006229-7yoilsho	92	4	background	background	NN
cord-006229-7yoilsho	92	5	β	β	NN
cord-006229-7yoilsho	92	6	1adrenoceptor	1adrenoceptor	CD
cord-006229-7yoilsho	92	7	overexpression	overexpression	NN
cord-006229-7yoilsho	92	8	alone	alone	RB
cord-006229-7yoilsho	92	9	had	have	VBD
cord-006229-7yoilsho	92	10	not	not	RB
cord-006229-7yoilsho	92	11	induced	induce	VBN
cord-006229-7yoilsho	92	12	cardiac	cardiac	JJ
cord-006229-7yoilsho	92	13	hypertrophy	hypertrophy	NN
cord-006229-7yoilsho	92	14	or	or	CC
cord-006229-7yoilsho	92	15	dysfunction	dysfunction	NN
cord-006229-7yoilsho	92	16	at	at	IN
cord-006229-7yoilsho	92	17	Day	day	NN
cord-006229-7yoilsho	92	18	300	300	CD
cord-006229-7yoilsho	92	19	while	while	IN
cord-006229-7yoilsho	92	20	there	there	EX
cord-006229-7yoilsho	92	21	was	be	VBD
cord-006229-7yoilsho	92	22	overt	overt	JJ
cord-006229-7yoilsho	92	23	cardiomyopathy	cardiomyopathy	NN
cord-006229-7yoilsho	92	24	in	in	IN
cord-006229-7yoilsho	92	25	mice	mice	NN
cord-006229-7yoilsho	92	26	additionally	additionally	RB
cord-006229-7yoilsho	92	27	lacking	lack	VBG
cord-006229-7yoilsho	92	28	Gα	Gα	NNP
cord-006229-7yoilsho	92	29	i2	i2	NNP
cord-006229-7yoilsho	92	30	.	.	.
cord-006229-7yoilsho	93	1	We	-PRON-	PRP
cord-006229-7yoilsho	93	2	propose	propose	VBP
cord-006229-7yoilsho	93	3	an	an	DT
cord-006229-7yoilsho	93	4	enhanced	enhanced	JJ
cord-006229-7yoilsho	93	5	effect	effect	NN
cord-006229-7yoilsho	93	6	of	of	IN
cord-006229-7yoilsho	93	7	increased	increase	VBN
cord-006229-7yoilsho	93	8	β	β	NN
cord-006229-7yoilsho	93	9	1	1	CD
cord-006229-7yoilsho	93	10	-adrenergic	-adrenergic	JJ
cord-006229-7yoilsho	93	11	drive	drive	NN
cord-006229-7yoilsho	93	12	by	by	IN
cord-006229-7yoilsho	93	13	lack	lack	NN
cord-006229-7yoilsho	93	14	of	of	IN
cord-006229-7yoilsho	93	15	protection	protection	NN
cord-006229-7yoilsho	93	16	via	via	IN
cord-006229-7yoilsho	93	17	Gα	Gα	NNP
cord-006229-7yoilsho	93	18	i2	i2	NNP
cord-006229-7yoilsho	93	19	.	.	.
cord-006229-7yoilsho	94	1	The	the	DT
cord-006229-7yoilsho	94	2	observed	observed	JJ
cord-006229-7yoilsho	94	3	Gα	Gα	NNP
cord-006229-7yoilsho	94	4	i3	i3	NNP
cord-006229-7yoilsho	94	5	upregulation	upregulation	NN
cord-006229-7yoilsho	94	6	was	be	VBD
cord-006229-7yoilsho	94	7	not	not	RB
cord-006229-7yoilsho	94	8	sufficient	sufficient	JJ
cord-006229-7yoilsho	94	9	to	to	TO
cord-006229-7yoilsho	94	10	compensate	compensate	VB
cord-006229-7yoilsho	94	11	for	for	IN
cord-006229-7yoilsho	94	12	Gα	Gα	NNP
cord-006229-7yoilsho	94	13	i2	i2	NNP
cord-006229-7yoilsho	94	14	deficiency	deficiency	NN
cord-006229-7yoilsho	94	15	suggesting	suggest	VBG
cord-006229-7yoilsho	94	16	an	an	DT
cord-006229-7yoilsho	94	17	isoform	isoform	NN
cord-006229-7yoilsho	94	18	-	-	HYPH
cord-006229-7yoilsho	94	19	specific	specific	JJ
cord-006229-7yoilsho	94	20	and/or	and/or	CC
cord-006229-7yoilsho	94	21	a	a	DT
cord-006229-7yoilsho	94	22	concentration	concentration	NN
cord-006229-7yoilsho	94	23	-	-	HYPH
cord-006229-7yoilsho	94	24	dependent	dependent	JJ
cord-006229-7yoilsho	94	25	mechanism	mechanism	NN
cord-006229-7yoilsho	94	26	.	.	.
cord-006229-7yoilsho	95	1	The	the	DT
cord-006229-7yoilsho	95	2	role	role	NN
cord-006229-7yoilsho	95	3	of	of	IN
cord-006229-7yoilsho	95	4	Gα	Gα	NNP
cord-006229-7yoilsho	95	5	i3	i3	NNP
cord-006229-7yoilsho	95	6	is	be	VBZ
cord-006229-7yoilsho	95	7	currently	currently	RB
cord-006229-7yoilsho	95	8	addressed	address	VBN
cord-006229-7yoilsho	95	9	in	in	IN
cord-006229-7yoilsho	95	10	a	a	DT
cord-006229-7yoilsho	95	11	subsequent	subsequent	JJ
cord-006229-7yoilsho	95	12	study	study	NN
cord-006229-7yoilsho	95	13	using	use	VBG
cord-006229-7yoilsho	95	14	β	β	NNP
cord-006229-7yoilsho	95	15	1	1	CD
cord-006229-7yoilsho	95	16	-tg	-tg	:
cord-006229-7yoilsho	95	17	and	and	CC
cord-006229-7yoilsho	95	18	Gα	Gα	NNP
cord-006229-7yoilsho	95	19	i3deficient	i3deficient	JJ
cord-006229-7yoilsho	95	20	mice	mouse	NNS
cord-006229-7yoilsho	95	21	.	.	.
cord-006229-7yoilsho	96	1	Heart	heart	NN
cord-006229-7yoilsho	96	2	failure	failure	NN
cord-006229-7yoilsho	96	3	is	be	VBZ
cord-006229-7yoilsho	96	4	accompanied	accompany	VBN
cord-006229-7yoilsho	96	5	by	by	IN
cord-006229-7yoilsho	96	6	morphological	morphological	JJ
cord-006229-7yoilsho	96	7	and	and	CC
cord-006229-7yoilsho	96	8	functional	functional	JJ
cord-006229-7yoilsho	96	9	alterations	alteration	NNS
cord-006229-7yoilsho	96	10	(	(	-LRB-
cord-006229-7yoilsho	96	11	e.g.	e.g.	IN
cord-006229-7yoilsho	96	12	hypertrophy	hypertrophy	NN
cord-006229-7yoilsho	96	13	,	,	,
cord-006229-7yoilsho	96	14	decreased	decrease	VBD
cord-006229-7yoilsho	96	15	contractility	contractility	NN
cord-006229-7yoilsho	96	16	)	)	-RRB-
cord-006229-7yoilsho	96	17	which	which	WDT
cord-006229-7yoilsho	96	18	are	be	VBP
cord-006229-7yoilsho	96	19	summarized	summarize	VBN
cord-006229-7yoilsho	96	20	by	by	IN
cord-006229-7yoilsho	96	21	the	the	DT
cord-006229-7yoilsho	96	22	term	term	NN
cord-006229-7yoilsho	96	23	"	"	``
cord-006229-7yoilsho	96	24	cardiac	cardiac	JJ
cord-006229-7yoilsho	96	25	remodeling	remodeling	NN
cord-006229-7yoilsho	96	26	"	"	''
cord-006229-7yoilsho	96	27	.	.	.
cord-006229-7yoilsho	97	1	While	while	IN
cord-006229-7yoilsho	97	2	the	the	DT
cord-006229-7yoilsho	97	3	β	β	NN
cord-006229-7yoilsho	97	4	-	-	HYPH
cord-006229-7yoilsho	97	5	adrenergic	adrenergic	NN
cord-006229-7yoilsho	97	6	signaling	signal	VBG
cord-006229-7yoilsho	97	7	pathway	pathway	NN
cord-006229-7yoilsho	97	8	is	be	VBZ
cord-006229-7yoilsho	97	9	essential	essential	JJ
cord-006229-7yoilsho	97	10	for	for	IN
cord-006229-7yoilsho	97	11	short	short	JJ
cord-006229-7yoilsho	97	12	-	-	HYPH
cord-006229-7yoilsho	97	13	term	term	NN
cord-006229-7yoilsho	97	14	modulation	modulation	NN
cord-006229-7yoilsho	97	15	of	of	IN
cord-006229-7yoilsho	97	16	cardiac	cardiac	JJ
cord-006229-7yoilsho	97	17	performance	performance	NN
cord-006229-7yoilsho	97	18	,	,	,
cord-006229-7yoilsho	97	19	its	-PRON-	PRP$
cord-006229-7yoilsho	97	20	chronic	chronic	JJ
cord-006229-7yoilsho	97	21	stimulation	stimulation	NN
cord-006229-7yoilsho	97	22	by	by	IN
cord-006229-7yoilsho	97	23	elevated	elevated	JJ
cord-006229-7yoilsho	97	24	plasma	plasma	NN
cord-006229-7yoilsho	97	25	catecholamines	catecholamine	NNS
cord-006229-7yoilsho	97	26	and	and	CC
cord-006229-7yoilsho	97	27	the	the	DT
cord-006229-7yoilsho	97	28	subsequent	subsequent	JJ
cord-006229-7yoilsho	97	29	activation	activation	NN
cord-006229-7yoilsho	97	30	of	of	IN
cord-006229-7yoilsho	97	31	cAMP	camp	NN
cord-006229-7yoilsho	97	32	-	-	HYPH
cord-006229-7yoilsho	97	33	dependent	dependent	JJ
cord-006229-7yoilsho	97	34	signal	signal	NN
cord-006229-7yoilsho	97	35	transduction	transduction	NN
cord-006229-7yoilsho	97	36	pathways	pathway	NNS
cord-006229-7yoilsho	97	37	is	be	VBZ
cord-006229-7yoilsho	97	38	regarded	regard	VBN
cord-006229-7yoilsho	97	39	as	as	IN
cord-006229-7yoilsho	97	40	a	a	DT
cord-006229-7yoilsho	97	41	fundamental	fundamental	JJ
cord-006229-7yoilsho	97	42	factor	factor	NN
cord-006229-7yoilsho	97	43	in	in	IN
cord-006229-7yoilsho	97	44	the	the	DT
cord-006229-7yoilsho	97	45	pathogenesis	pathogenesis	NN
cord-006229-7yoilsho	97	46	of	of	IN
cord-006229-7yoilsho	97	47	cardiac	cardiac	JJ
cord-006229-7yoilsho	97	48	remodeling	remodeling	NN
cord-006229-7yoilsho	97	49	.	.	.
cord-006229-7yoilsho	98	1	However	however	RB
cord-006229-7yoilsho	98	2	,	,	,
cord-006229-7yoilsho	98	3	the	the	DT
cord-006229-7yoilsho	98	4	mechanisms	mechanism	NNS
cord-006229-7yoilsho	98	5	mediating	mediate	VBG
cord-006229-7yoilsho	98	6	the	the	DT
cord-006229-7yoilsho	98	7	transition	transition	NN
cord-006229-7yoilsho	98	8	of	of	IN
cord-006229-7yoilsho	98	9	physiological	physiological	JJ
cord-006229-7yoilsho	98	10	conditions	condition	NNS
cord-006229-7yoilsho	98	11	of	of	IN
cord-006229-7yoilsho	98	12	short	short	JJ
cord-006229-7yoilsho	98	13	-	-	HYPH
cord-006229-7yoilsho	98	14	term	term	NN
cord-006229-7yoilsho	98	15	to	to	IN
cord-006229-7yoilsho	98	16	detrimental	detrimental	JJ
cord-006229-7yoilsho	98	17	remodeling	remodeling	NN
cord-006229-7yoilsho	98	18	under	under	IN
cord-006229-7yoilsho	98	19	long	long	JJ
cord-006229-7yoilsho	98	20	-	-	HYPH
cord-006229-7yoilsho	98	21	term	term	NN
cord-006229-7yoilsho	98	22	β	β	NN
cord-006229-7yoilsho	98	23	-	-	HYPH
cord-006229-7yoilsho	98	24	adrenergic	adrenergic	JJ
cord-006229-7yoilsho	98	25	stimulation	stimulation	NN
cord-006229-7yoilsho	98	26	are	be	VBP
cord-006229-7yoilsho	98	27	not	not	RB
cord-006229-7yoilsho	98	28	understood	understand	VBN
cord-006229-7yoilsho	98	29	in	in	IN
cord-006229-7yoilsho	98	30	detail	detail	NN
cord-006229-7yoilsho	98	31	so	so	RB
cord-006229-7yoilsho	98	32	far	far	RB
cord-006229-7yoilsho	98	33	.	.	.
cord-006229-7yoilsho	99	1	In	in	IN
cord-006229-7yoilsho	99	2	this	this	DT
cord-006229-7yoilsho	99	3	context	context	NN
cord-006229-7yoilsho	99	4	,	,	,
cord-006229-7yoilsho	99	5	ICER	ICER	NNP
cord-006229-7yoilsho	99	6	,	,	,
cord-006229-7yoilsho	99	7	an	an	DT
cord-006229-7yoilsho	99	8	isoform	isoform	NN
cord-006229-7yoilsho	99	9	of	of	IN
cord-006229-7yoilsho	99	10	the	the	DT
cord-006229-7yoilsho	99	11	cAMP	camp	NN
cord-006229-7yoilsho	99	12	dependent	dependent	JJ
cord-006229-7yoilsho	99	13	transcription	transcription	NN
cord-006229-7yoilsho	99	14	factor	factor	NN
cord-006229-7yoilsho	99	15	CREM	CREM	NNP
cord-006229-7yoilsho	99	16	(	(	-LRB-
cord-006229-7yoilsho	99	17	cAMP	camp	NN
cord-006229-7yoilsho	99	18	responsive	responsive	JJ
cord-006229-7yoilsho	99	19	element	element	NN
cord-006229-7yoilsho	99	20	modulator	modulator	NN
cord-006229-7yoilsho	99	21	)	)	-RRB-
cord-006229-7yoilsho	99	22	,	,	,
cord-006229-7yoilsho	99	23	acts	act	VBZ
cord-006229-7yoilsho	99	24	as	as	IN
cord-006229-7yoilsho	99	25	an	an	DT
cord-006229-7yoilsho	99	26	early	early	JJ
cord-006229-7yoilsho	99	27	response	response	NN
cord-006229-7yoilsho	99	28	gene	gene	NN
cord-006229-7yoilsho	99	29	strongly	strongly	RB
cord-006229-7yoilsho	99	30	induced	induce	VBN
cord-006229-7yoilsho	99	31	by	by	IN
cord-006229-7yoilsho	99	32	beta	beta	JJ
cord-006229-7yoilsho	99	33	-	-	HYPH
cord-006229-7yoilsho	99	34	adrenergic	adrenergic	NN
cord-006229-7yoilsho	99	35	stimulation	stimulation	NN
cord-006229-7yoilsho	99	36	via	via	IN
cord-006229-7yoilsho	99	37	cAMP	camp	NN
cord-006229-7yoilsho	99	38	responsive	responsive	JJ
cord-006229-7yoilsho	99	39	elements	element	NNS
cord-006229-7yoilsho	99	40	(	(	-LRB-
cord-006229-7yoilsho	99	41	CRE	CRE	NNP
cord-006229-7yoilsho	99	42	)	)	-RRB-
cord-006229-7yoilsho	99	43	in	in	IN
cord-006229-7yoilsho	99	44	its	-PRON-	PRP$
cord-006229-7yoilsho	99	45	promoter	promoter	NN
cord-006229-7yoilsho	99	46	.	.	.
cord-006229-7yoilsho	100	1	Contrary	contrary	JJ
cord-006229-7yoilsho	100	2	to	to	IN
cord-006229-7yoilsho	100	3	its	-PRON-	PRP$
cord-006229-7yoilsho	100	4	CRE	cre	NN
cord-006229-7yoilsho	100	5	-	-	HYPH
cord-006229-7yoilsho	100	6	mediated	mediate	VBN
cord-006229-7yoilsho	100	7	induction	induction	NN
cord-006229-7yoilsho	100	8	,	,	,
cord-006229-7yoilsho	100	9	ICER	ICER	NNP
cord-006229-7yoilsho	100	10	is	be	VBZ
cord-006229-7yoilsho	100	11	a	a	DT
cord-006229-7yoilsho	100	12	strong	strong	JJ
cord-006229-7yoilsho	100	13	inhibitor	inhibitor	NN
cord-006229-7yoilsho	100	14	of	of	IN
cord-006229-7yoilsho	100	15	CRE	cre	NN
cord-006229-7yoilsho	100	16	-	-	HYPH
cord-006229-7yoilsho	100	17	mediated	mediate	VBN
cord-006229-7yoilsho	100	18	transcription	transcription	NN
cord-006229-7yoilsho	100	19	by	by	IN
cord-006229-7yoilsho	100	20	itself	-PRON-	PRP
cord-006229-7yoilsho	100	21	.	.	.
cord-006229-7yoilsho	101	1	Here	here	RB
cord-006229-7yoilsho	101	2	we	-PRON-	PRP
cord-006229-7yoilsho	101	3	study	study	VBP
cord-006229-7yoilsho	101	4	the	the	DT
cord-006229-7yoilsho	101	5	role	role	NN
cord-006229-7yoilsho	101	6	of	of	IN
cord-006229-7yoilsho	101	7	ICER	ICER	NNP
cord-006229-7yoilsho	101	8	induction	induction	NN
cord-006229-7yoilsho	101	9	in	in	IN
cord-006229-7yoilsho	101	10	the	the	DT
cord-006229-7yoilsho	101	11	catecholamine	catecholamine	NN
cord-006229-7yoilsho	101	12	-	-	HYPH
cord-006229-7yoilsho	101	13	induced	induce	VBN
cord-006229-7yoilsho	101	14	cardiac	cardiac	JJ
cord-006229-7yoilsho	101	15	remodeling	remodeling	NN
cord-006229-7yoilsho	101	16	in	in	IN
cord-006229-7yoilsho	101	17	a	a	DT
cord-006229-7yoilsho	101	18	time	time	NN
cord-006229-7yoilsho	101	19	dependent	dependent	JJ
cord-006229-7yoilsho	101	20	manner	manner	NN
cord-006229-7yoilsho	101	21	by	by	IN
cord-006229-7yoilsho	101	22	the	the	DT
cord-006229-7yoilsho	101	23	use	use	NN
cord-006229-7yoilsho	101	24	of	of	IN
cord-006229-7yoilsho	101	25	ICER	ICER	NNP
cord-006229-7yoilsho	101	26	deficient	deficient	JJ
cord-006229-7yoilsho	101	27	mice	mouse	NNS
cord-006229-7yoilsho	101	28	(	(	-LRB-
cord-006229-7yoilsho	101	29	IKO	IKO	NNP
cord-006229-7yoilsho	101	30	)	)	-RRB-
cord-006229-7yoilsho	101	31	and	and	CC
cord-006229-7yoilsho	101	32	wild	wild	JJ
cord-006229-7yoilsho	101	33	type	type	NN
cord-006229-7yoilsho	101	34	(	(	-LRB-
cord-006229-7yoilsho	101	35	WT	WT	NNP
cord-006229-7yoilsho	101	36	)	)	-RRB-
cord-006229-7yoilsho	101	37	controls	control	NNS
cord-006229-7yoilsho	101	38	,	,	,
cord-006229-7yoilsho	101	39	which	which	WDT
cord-006229-7yoilsho	101	40	were	be	VBD
cord-006229-7yoilsho	101	41	treated	treat	VBN
cord-006229-7yoilsho	101	42	with	with	IN
cord-006229-7yoilsho	101	43	isoproterenol	isoproterenol	NN
cord-006229-7yoilsho	101	44	(	(	-LRB-
cord-006229-7yoilsho	101	45	ISO	iso	NN
cord-006229-7yoilsho	101	46	;	;	:
cord-006229-7yoilsho	101	47	10	10	CD
cord-006229-7yoilsho	101	48	mg	mg	NN
cord-006229-7yoilsho	101	49	/	/	SYM
cord-006229-7yoilsho	101	50	kg	kg	NN
cord-006229-7yoilsho	101	51	per	per	IN
cord-006229-7yoilsho	101	52	d	d	NN
cord-006229-7yoilsho	101	53	)	)	-RRB-
cord-006229-7yoilsho	101	54	for	for	IN
cord-006229-7yoilsho	101	55	6	6	CD
cord-006229-7yoilsho	101	56	and	and	CC
cord-006229-7yoilsho	101	57	24	24	CD
cord-006229-7yoilsho	101	58	hours	hour	NNS
cord-006229-7yoilsho	101	59	and	and	CC
cord-006229-7yoilsho	101	60	7	7	CD
cord-006229-7yoilsho	101	61	days	day	NNS
cord-006229-7yoilsho	101	62	.	.	.
cord-006229-7yoilsho	102	1	Overall	overall	JJ
cord-006229-7yoilsho	102	2	7	7	CD
cord-006229-7yoilsho	102	3	days	day	NNS
cord-006229-7yoilsho	102	4	of	of	IN
cord-006229-7yoilsho	102	5	ISO	iso	NN
cord-006229-7yoilsho	102	6	stimulation	stimulation	NN
cord-006229-7yoilsho	102	7	resulted	result	VBD
cord-006229-7yoilsho	102	8	in	in	IN
cord-006229-7yoilsho	102	9	an	an	DT
cord-006229-7yoilsho	102	10	elevation	elevation	NN
cord-006229-7yoilsho	102	11	of	of	IN
cord-006229-7yoilsho	102	12	cardiomyocyte	cardiomyocyte	NNP
cord-006229-7yoilsho	102	13	length	length	NN
cord-006229-7yoilsho	102	14	in	in	IN
cord-006229-7yoilsho	102	15	IKO	IKO	NNP
cord-006229-7yoilsho	102	16	(	(	-LRB-
cord-006229-7yoilsho	102	17	in	in	IN
cord-006229-7yoilsho	102	18	µm	µm	NN
cord-006229-7yoilsho	102	19	;	;	:
cord-006229-7yoilsho	102	20	7d	7d	NNP
cord-006229-7yoilsho	102	21	ISO	ISO	NNP
cord-006229-7yoilsho	102	22	156±1	156±1	CD
cord-006229-7yoilsho	102	23	)	)	-RRB-
cord-006229-7yoilsho	102	24	vs.	vs.	IN
cord-006229-7yoilsho	102	25	WT	wt	NN
cord-006229-7yoilsho	102	26	cardiomyocytes	cardiomyocyte	NNS
cord-006229-7yoilsho	102	27	(	(	-LRB-
cord-006229-7yoilsho	102	28	7d	7d	NNP
cord-006229-7yoilsho	102	29	ISO	ISO	NNP
cord-006229-7yoilsho	102	30	143±2	143±2	CD
cord-006229-7yoilsho	102	31	)	)	-RRB-
cord-006229-7yoilsho	102	32	.	.	.
cord-006229-7yoilsho	103	1	At	at	IN
cord-006229-7yoilsho	103	2	this	this	DT
cord-006229-7yoilsho	103	3	time	time	NN
cord-006229-7yoilsho	103	4	point	point	NN
cord-006229-7yoilsho	103	5	a	a	DT
cord-006229-7yoilsho	103	6	29	29	CD
cord-006229-7yoilsho	103	7	%	%	NN
cord-006229-7yoilsho	103	8	decrease	decrease	NN
cord-006229-7yoilsho	103	9	of	of	IN
cord-006229-7yoilsho	103	10	cardiac	cardiac	JJ
cord-006229-7yoilsho	103	11	output	output	NN
cord-006229-7yoilsho	103	12	and	and	CC
cord-006229-7yoilsho	103	13	a	a	DT
cord-006229-7yoilsho	103	14	16	16	CD
cord-006229-7yoilsho	103	15	%	%	NN
cord-006229-7yoilsho	103	16	decrease	decrease	NN
cord-006229-7yoilsho	103	17	of	of	IN
cord-006229-7yoilsho	103	18	the	the	DT
cord-006229-7yoilsho	103	19	maximal	maximal	JJ
cord-006229-7yoilsho	103	20	rate	rate	NN
cord-006229-7yoilsho	103	21	of	of	IN
cord-006229-7yoilsho	103	22	rise	rise	NN
cord-006229-7yoilsho	103	23	of	of	IN
cord-006229-7yoilsho	103	24	left	left	JJ
cord-006229-7yoilsho	103	25	ventricular	ventricular	JJ
cord-006229-7yoilsho	103	26	pressure	pressure	NN
cord-006229-7yoilsho	103	27	(	(	-LRB-
cord-006229-7yoilsho	103	28	dp	dp	NNP
cord-006229-7yoilsho	103	29	/	/	SYM
cord-006229-7yoilsho	103	30	dt	dt	NNP
cord-006229-7yoilsho	103	31	max	max	NNP
cord-006229-7yoilsho	103	32	)	)	-RRB-
cord-006229-7yoilsho	103	33	in	in	IN
cord-006229-7yoilsho	103	34	IKO	IKO	NNP
cord-006229-7yoilsho	103	35	vs.	vs.	IN
cord-006229-7yoilsho	103	36	WT	WT	NNP
cord-006229-7yoilsho	103	37	animals	animal	NNS
cord-006229-7yoilsho	103	38	was	be	VBD
cord-006229-7yoilsho	103	39	detectable	detectable	JJ
cord-006229-7yoilsho	103	40	.	.	.
cord-006229-7yoilsho	104	1	The	the	DT
cord-006229-7yoilsho	104	2	maximum	maximum	JJ
cord-006229-7yoilsho	104	3	increase	increase	NN
cord-006229-7yoilsho	104	4	of	of	IN
cord-006229-7yoilsho	104	5	Icer	Icer	NNP
cord-006229-7yoilsho	104	6	mRNA	mRNA	NNP
cord-006229-7yoilsho	104	7	in	in	IN
cord-006229-7yoilsho	104	8	WT	WT	NNP
cord-006229-7yoilsho	104	9	cardiomyocytes	cardiomyocyte	NNS
cord-006229-7yoilsho	104	10	already	already	RB
cord-006229-7yoilsho	104	11	occurred	occur	VBD
cord-006229-7yoilsho	104	12	after	after	IN
cord-006229-7yoilsho	104	13	6	6	CD
cord-006229-7yoilsho	104	14	h	h	NN
cord-006229-7yoilsho	104	15	(	(	-LRB-
cord-006229-7yoilsho	104	16	75-fold	75-fold	CD
cord-006229-7yoilsho	104	17	)	)	-RRB-
cord-006229-7yoilsho	104	18	,	,	,
cord-006229-7yoilsho	104	19	and	and	CC
cord-006229-7yoilsho	104	20	declined	decline	VBD
cord-006229-7yoilsho	104	21	after	after	IN
cord-006229-7yoilsho	104	22	24	24	CD
cord-006229-7yoilsho	104	23	h	h	NNP
cord-006229-7yoilsho	104	24	(	(	-LRB-
cord-006229-7yoilsho	104	25	29-fold	29-fold	CD
cord-006229-7yoilsho	104	26	)	)	-RRB-
cord-006229-7yoilsho	104	27	to	to	IN
cord-006229-7yoilsho	104	28	2.5	2.5	CD
cord-006229-7yoilsho	104	29	fold	fold	JJ
cord-006229-7yoilsho	104	30	increase	increase	NN
cord-006229-7yoilsho	104	31	after	after	IN
cord-006229-7yoilsho	104	32	7	7	CD
cord-006229-7yoilsho	104	33	days	day	NNS
cord-006229-7yoilsho	104	34	,	,	,
cord-006229-7yoilsho	104	35	while	while	IN
cord-006229-7yoilsho	104	36	Icer	Icer	NNP
cord-006229-7yoilsho	104	37	mRNA	mRNA	NNP
cord-006229-7yoilsho	104	38	was	be	VBD
cord-006229-7yoilsho	104	39	not	not	RB
cord-006229-7yoilsho	104	40	detectable	detectable	JJ
cord-006229-7yoilsho	104	41	in	in	IN
cord-006229-7yoilsho	104	42	IKO	IKO	NNP
cord-006229-7yoilsho	104	43	mice	mouse	NNS
cord-006229-7yoilsho	104	44	.	.	.
cord-006229-7yoilsho	105	1	This	this	DT
cord-006229-7yoilsho	105	2	raised	raise	VBD
cord-006229-7yoilsho	105	3	the	the	DT
cord-006229-7yoilsho	105	4	hypothesis	hypothesis	NN
cord-006229-7yoilsho	105	5	,	,	,
cord-006229-7yoilsho	105	6	that	that	IN
cord-006229-7yoilsho	105	7	the	the	DT
cord-006229-7yoilsho	105	8	early	early	JJ
cord-006229-7yoilsho	105	9	induction	induction	NN
cord-006229-7yoilsho	105	10	of	of	IN
cord-006229-7yoilsho	105	11	ICER	ICER	NNP
cord-006229-7yoilsho	105	12	modulates	modulate	VBZ
cord-006229-7yoilsho	105	13	transcriptional	transcriptional	JJ
cord-006229-7yoilsho	105	14	processes	process	NNS
cord-006229-7yoilsho	105	15	after	after	IN
cord-006229-7yoilsho	105	16	beta	beta	NN
cord-006229-7yoilsho	105	17	-	-	HYPH
cord-006229-7yoilsho	105	18	adrenergicstimulation	adrenergicstimulation	NN
cord-006229-7yoilsho	105	19	,	,	,
cord-006229-7yoilsho	105	20	involved	involve	VBN
cord-006229-7yoilsho	105	21	in	in	IN
cord-006229-7yoilsho	105	22	cardiac	cardiac	JJ
cord-006229-7yoilsho	105	23	remodeling	remodeling	NN
cord-006229-7yoilsho	105	24	of	of	IN
cord-006229-7yoilsho	105	25	the	the	DT
cord-006229-7yoilsho	105	26	heart	heart	NN
cord-006229-7yoilsho	105	27	.	.	.
cord-006229-7yoilsho	106	1	Profiling	profiling	NN
cord-006229-7yoilsho	106	2	of	of	IN
cord-006229-7yoilsho	106	3	mRNA	mrna	NN
cord-006229-7yoilsho	106	4	expression	expression	NN
cord-006229-7yoilsho	106	5	levels	level	NNS
cord-006229-7yoilsho	106	6	between	between	IN
cord-006229-7yoilsho	106	7	IKO	IKO	NNP
cord-006229-7yoilsho	106	8	vs.	vs.	IN
cord-006229-7yoilsho	106	9	WT	wt	NN
cord-006229-7yoilsho	106	10	cardiomyocytes	cardiomyocyte	NNS
cord-006229-7yoilsho	106	11	at	at	IN
cord-006229-7yoilsho	106	12	the	the	DT
cord-006229-7yoilsho	106	13	different	different	JJ
cord-006229-7yoilsho	106	14	time	time	NN
cord-006229-7yoilsho	106	15	points	point	NNS
cord-006229-7yoilsho	106	16	revealed	reveal	VBD
cord-006229-7yoilsho	106	17	:	:	:
cord-006229-7yoilsho	106	18	55	55	CD
cord-006229-7yoilsho	106	19	regulated	regulate	VBN
cord-006229-7yoilsho	106	20	genes	gene	NNS
cord-006229-7yoilsho	106	21	(	(	-LRB-
cord-006229-7yoilsho	106	22	up	up	RB
cord-006229-7yoilsho	106	23	-	-	HYPH
cord-006229-7yoilsho	106	24	regulated	regulate	VBN
cord-006229-7yoilsho	106	25	:	:	:
cord-006229-7yoilsho	106	26	45	45	CD
cord-006229-7yoilsho	106	27	%	%	NN
cord-006229-7yoilsho	106	28	)	)	-RRB-
cord-006229-7yoilsho	106	29	in	in	IN
cord-006229-7yoilsho	106	30	untreated	untreated	JJ
cord-006229-7yoilsho	106	31	;	;	:
cord-006229-7yoilsho	106	32	103	103	CD
cord-006229-7yoilsho	106	33	altered	alter	VBN
cord-006229-7yoilsho	106	34	genes	gene	NNS
cord-006229-7yoilsho	106	35	(	(	-LRB-
cord-006229-7yoilsho	106	36	up	up	RB
cord-006229-7yoilsho	106	37	35	35	CD
cord-006229-7yoilsho	106	38	%	%	NN
cord-006229-7yoilsho	106	39	)	)	-RRB-
cord-006229-7yoilsho	106	40	after	after	IN
cord-006229-7yoilsho	106	41	6h	6h	CD
cord-006229-7yoilsho	106	42	;	;	:
cord-006229-7yoilsho	106	43	1437	1437	CD
cord-006229-7yoilsho	106	44	changed	change	VBN
cord-006229-7yoilsho	106	45	genes	gene	NNS
cord-006229-7yoilsho	106	46	(	(	-LRB-
cord-006229-7yoilsho	106	47	up	up	RB
cord-006229-7yoilsho	106	48	97	97	CD
cord-006229-7yoilsho	106	49	%	%	NN
cord-006229-7yoilsho	106	50	)	)	-RRB-
cord-006229-7yoilsho	106	51	after	after	IN
cord-006229-7yoilsho	106	52	24	24	CD
cord-006229-7yoilsho	106	53	h	h	NN
cord-006229-7yoilsho	106	54	and	and	CC
cord-006229-7yoilsho	106	55	131	131	CD
cord-006229-7yoilsho	106	56	altered	alter	VBN
cord-006229-7yoilsho	106	57	genes	gene	NNS
cord-006229-7yoilsho	106	58	(	(	-LRB-
cord-006229-7yoilsho	106	59	up	up	RB
cord-006229-7yoilsho	106	60	19	19	CD
cord-006229-7yoilsho	106	61	%	%	NN
cord-006229-7yoilsho	106	62	)	)	-RRB-
cord-006229-7yoilsho	106	63	after	after	IN
cord-006229-7yoilsho	106	64	7	7	CD
cord-006229-7yoilsho	106	65	days	day	NNS
cord-006229-7yoilsho	106	66	of	of	IN
cord-006229-7yoilsho	106	67	ISO	iso	NN
cord-006229-7yoilsho	106	68	treatment	treatment	NN
cord-006229-7yoilsho	106	69	.	.	.
cord-006229-7yoilsho	107	1	In	in	IN
cord-006229-7yoilsho	107	2	summary	summary	NN
cord-006229-7yoilsho	107	3	,	,	,
cord-006229-7yoilsho	107	4	the	the	DT
cord-006229-7yoilsho	107	5	absence	absence	NN
cord-006229-7yoilsho	107	6	of	of	IN
cord-006229-7yoilsho	107	7	ICER	ICER	NNP
cord-006229-7yoilsho	107	8	induction	induction	NN
cord-006229-7yoilsho	107	9	in	in	IN
cord-006229-7yoilsho	107	10	myocytes	myocyte	NNS
cord-006229-7yoilsho	107	11	resulted	result	VBN
cord-006229-7yoilsho	107	12	in	in	IN
cord-006229-7yoilsho	107	13	an	an	DT
cord-006229-7yoilsho	107	14	increase	increase	NN
cord-006229-7yoilsho	107	15	of	of	IN
cord-006229-7yoilsho	107	16	cardiomyocytes	cardiomyocyte	NNS
cord-006229-7yoilsho	107	17	length	length	NN
cord-006229-7yoilsho	107	18	and	and	CC
cord-006229-7yoilsho	107	19	a	a	DT
cord-006229-7yoilsho	107	20	decrease	decrease	NN
cord-006229-7yoilsho	107	21	of	of	IN
cord-006229-7yoilsho	107	22	heart	heart	NN
cord-006229-7yoilsho	107	23	performance	performance	NN
cord-006229-7yoilsho	107	24	after	after	IN
cord-006229-7yoilsho	107	25	7	7	CD
cord-006229-7yoilsho	107	26	days	day	NNS
cord-006229-7yoilsho	107	27	of	of	IN
cord-006229-7yoilsho	107	28	betaadrenergic	betaadrenergic	JJ
cord-006229-7yoilsho	107	29	stimulation	stimulation	NN
cord-006229-7yoilsho	107	30	.	.	.
cord-006229-7yoilsho	108	1	This	this	DT
cord-006229-7yoilsho	108	2	is	be	VBZ
cord-006229-7yoilsho	108	3	preceded	precede	VBN
cord-006229-7yoilsho	108	4	by	by	IN
cord-006229-7yoilsho	108	5	upregulated	upregulate	VBN
cord-006229-7yoilsho	108	6	mRNA	mrna	NN
cord-006229-7yoilsho	108	7	levels	level	NNS
cord-006229-7yoilsho	108	8	of	of	IN
cord-006229-7yoilsho	108	9	several	several	JJ
cord-006229-7yoilsho	108	10	hundred	hundred	CD
cord-006229-7yoilsho	108	11	genes	gene	NNS
cord-006229-7yoilsho	108	12	at	at	IN
cord-006229-7yoilsho	108	13	24	24	CD
cord-006229-7yoilsho	108	14	h	h	NN
cord-006229-7yoilsho	108	15	,	,	,
cord-006229-7yoilsho	108	16	which	which	WDT
cord-006229-7yoilsho	108	17	is	be	VBZ
cord-006229-7yoilsho	108	18	going	go	VBG
cord-006229-7yoilsho	108	19	along	along	RP
cord-006229-7yoilsho	108	20	with	with	IN
cord-006229-7yoilsho	108	21	the	the	DT
cord-006229-7yoilsho	108	22	induction	induction	NN
cord-006229-7yoilsho	108	23	of	of	IN
cord-006229-7yoilsho	108	24	transcriptional	transcriptional	JJ
cord-006229-7yoilsho	108	25	inhibitor	inhibitor	NN
cord-006229-7yoilsho	108	26	ICER	ICER	NNP
cord-006229-7yoilsho	108	27	after	after	IN
cord-006229-7yoilsho	108	28	a	a	DT
cord-006229-7yoilsho	108	29	few	few	JJ
cord-006229-7yoilsho	108	30	hours	hour	NNS
cord-006229-7yoilsho	108	31	of	of	IN
cord-006229-7yoilsho	108	32	beta	beta	JJ
cord-006229-7yoilsho	108	33	-	-	HYPH
cord-006229-7yoilsho	108	34	adrenergic	adrenergic	NN
cord-006229-7yoilsho	108	35	stimulation	stimulation	NN
cord-006229-7yoilsho	108	36	.	.	.
cord-006229-7yoilsho	109	1	This	this	DT
cord-006229-7yoilsho	109	2	suggested	suggest	VBD
cord-006229-7yoilsho	109	3	a	a	DT
cord-006229-7yoilsho	109	4	protective	protective	JJ
cord-006229-7yoilsho	109	5	role	role	NN
cord-006229-7yoilsho	109	6	of	of	IN
cord-006229-7yoilsho	109	7	ICER	ICER	NNP
cord-006229-7yoilsho	109	8	by	by	IN
cord-006229-7yoilsho	109	9	inhibiting	inhibit	VBG
cord-006229-7yoilsho	109	10	the	the	DT
cord-006229-7yoilsho	109	11	progression	progression	NN
cord-006229-7yoilsho	109	12	of	of	IN
cord-006229-7yoilsho	109	13	cardiac	cardiac	JJ
cord-006229-7yoilsho	109	14	remodeling	remodeling	NN
cord-006229-7yoilsho	109	15	after	after	IN
cord-006229-7yoilsho	109	16	betaadrenergic	betaadrenergic	JJ
cord-006229-7yoilsho	109	17	stimulation	stimulation	NN
cord-006229-7yoilsho	109	18	in	in	IN
cord-006229-7yoilsho	109	19	an	an	DT
cord-006229-7yoilsho	109	20	early	early	JJ
cord-006229-7yoilsho	109	21	responsive	responsive	JJ
cord-006229-7yoilsho	109	22	manner	manner	NN
cord-006229-7yoilsho	109	23	.	.	.
cord-006229-7yoilsho	110	1	(	(	-LRB-
cord-006229-7yoilsho	110	2	Supported	support	VBN
cord-006229-7yoilsho	110	3	by	by	IN
cord-006229-7yoilsho	110	4	the	the	DT
cord-006229-7yoilsho	110	5	DFG	DFG	NNP
cord-006229-7yoilsho	110	6	)	)	-RRB-
cord-006229-7yoilsho	111	1	The	the	DT
cord-006229-7yoilsho	111	2	performance	performance	NN
cord-006229-7yoilsho	111	3	of	of	IN
cord-006229-7yoilsho	111	4	the	the	DT
cord-006229-7yoilsho	111	5	adult	adult	NN
cord-006229-7yoilsho	111	6	heart	heart	NN
cord-006229-7yoilsho	111	7	is	be	VBZ
cord-006229-7yoilsho	111	8	tightly	tightly	RB
cord-006229-7yoilsho	111	9	regulated	regulate	VBN
cord-006229-7yoilsho	111	10	by	by	IN
cord-006229-7yoilsho	111	11	G	g	NN
cord-006229-7yoilsho	111	12	protein	protein	NN
cord-006229-7yoilsho	111	13	-	-	HYPH
cord-006229-7yoilsho	111	14	coupled	couple	VBN
cord-006229-7yoilsho	111	15	receptors	receptor	NNS
cord-006229-7yoilsho	111	16	.	.	.
cord-006229-7yoilsho	112	1	Adrenergic	Adrenergic	NNP
cord-006229-7yoilsho	112	2	and	and	CC
cord-006229-7yoilsho	112	3	Angiotensin	Angiotensin	NNP
cord-006229-7yoilsho	112	4	receptors	receptor	NNS
cord-006229-7yoilsho	112	5	efficiently	efficiently	RB
cord-006229-7yoilsho	112	6	control	control	VBP
cord-006229-7yoilsho	112	7	heart	heart	NN
cord-006229-7yoilsho	112	8	rate	rate	NN
cord-006229-7yoilsho	112	9	and	and	CC
cord-006229-7yoilsho	112	10	contractility	contractility	NN
cord-006229-7yoilsho	112	11	.	.	.
cord-006229-7yoilsho	113	1	Muscarinic	muscarinic	JJ
cord-006229-7yoilsho	113	2	receptors	receptor	NNS
cord-006229-7yoilsho	113	3	,	,	,
cord-006229-7yoilsho	113	4	on	on	IN
cord-006229-7yoilsho	113	5	the	the	DT
cord-006229-7yoilsho	113	6	other	other	JJ
cord-006229-7yoilsho	113	7	hand	hand	NN
cord-006229-7yoilsho	113	8	serve	serve	VBP
cord-006229-7yoilsho	113	9	as	as	IN
cord-006229-7yoilsho	113	10	master	master	NN
cord-006229-7yoilsho	113	11	regulators	regulator	NNS
cord-006229-7yoilsho	113	12	of	of	IN
cord-006229-7yoilsho	113	13	the	the	DT
cord-006229-7yoilsho	113	14	conduction	conduction	NN
cord-006229-7yoilsho	113	15	system	system	NN
cord-006229-7yoilsho	113	16	,	,	,
cord-006229-7yoilsho	113	17	which	which	WDT
cord-006229-7yoilsho	113	18	is	be	VBZ
cord-006229-7yoilsho	113	19	often	often	RB
cord-006229-7yoilsho	113	20	lost	lose	VBN
cord-006229-7yoilsho	113	21	upon	upon	IN
cord-006229-7yoilsho	113	22	myocardial	myocardial	JJ
cord-006229-7yoilsho	113	23	infarction	infarction	NN
cord-006229-7yoilsho	113	24	.	.	.
cord-006229-7yoilsho	114	1	This	this	DT
cord-006229-7yoilsho	114	2	function	function	NN
cord-006229-7yoilsho	114	3	of	of	IN
cord-006229-7yoilsho	114	4	muscarinic	muscarinic	JJ
cord-006229-7yoilsho	114	5	receptors	receptor	NNS
cord-006229-7yoilsho	114	6	has	have	VBZ
cord-006229-7yoilsho	114	7	been	be	VBN
cord-006229-7yoilsho	114	8	well	well	RB
cord-006229-7yoilsho	114	9	described	describe	VBN
cord-006229-7yoilsho	114	10	in	in	IN
cord-006229-7yoilsho	114	11	the	the	DT
cord-006229-7yoilsho	114	12	adult	adult	NN
cord-006229-7yoilsho	114	13	or	or	CC
cord-006229-7yoilsho	114	14	late	late	JJ
cord-006229-7yoilsho	114	15	embryonic	embryonic	JJ
cord-006229-7yoilsho	114	16	heart	heart	NN
cord-006229-7yoilsho	114	17	.	.	.
cord-006229-7yoilsho	115	1	Here	here	RB
cord-006229-7yoilsho	115	2	we	-PRON-	PRP
cord-006229-7yoilsho	115	3	provide	provide	VBP
cord-006229-7yoilsho	115	4	evidence	evidence	NN
cord-006229-7yoilsho	115	5	that	that	IN
cord-006229-7yoilsho	115	6	muscarinic	muscarinic	JJ
cord-006229-7yoilsho	115	7	receptors	receptor	NNS
cord-006229-7yoilsho	115	8	are	be	VBP
cord-006229-7yoilsho	115	9	crucial	crucial	JJ
cord-006229-7yoilsho	115	10	to	to	TO
cord-006229-7yoilsho	115	11	constrain	constrain	VB
cord-006229-7yoilsho	115	12	pacemaker	pacemaker	NN
cord-006229-7yoilsho	115	13	cell	cell	NN
cord-006229-7yoilsho	115	14	identity	identity	NN
cord-006229-7yoilsho	115	15	.	.	.
cord-006229-7yoilsho	116	1	We	-PRON-	PRP
cord-006229-7yoilsho	116	2	applied	apply	VBD
cord-006229-7yoilsho	116	3	subtype	subtype	NN
cord-006229-7yoilsho	116	4	-	-	HYPH
cord-006229-7yoilsho	116	5	specific	specific	JJ
cord-006229-7yoilsho	116	6	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	116	7	of	of	IN
cord-006229-7yoilsho	116	8	muscarinic	muscarinic	JJ
cord-006229-7yoilsho	116	9	receptors	receptor	NNS
cord-006229-7yoilsho	116	10	to	to	IN
cord-006229-7yoilsho	116	11	zebrafish	zebrafish	NN
cord-006229-7yoilsho	116	12	embryos	embryo	NNS
cord-006229-7yoilsho	116	13	of	of	IN
cord-006229-7yoilsho	116	14	different	different	JJ
cord-006229-7yoilsho	116	15	stages	stage	NNS
cord-006229-7yoilsho	116	16	.	.	.
cord-006229-7yoilsho	117	1	We	-PRON-	PRP
cord-006229-7yoilsho	117	2	observed	observe	VBD
cord-006229-7yoilsho	117	3	that	that	IN
cord-006229-7yoilsho	117	4	both	both	DT
cord-006229-7yoilsho	117	5	,	,	,
cord-006229-7yoilsho	117	6	early	early	JJ
cord-006229-7yoilsho	117	7	cardiac	cardiac	JJ
cord-006229-7yoilsho	117	8	function	function	NN
cord-006229-7yoilsho	117	9	as	as	RB
cord-006229-7yoilsho	117	10	well	well	RB
cord-006229-7yoilsho	117	11	as	as	IN
cord-006229-7yoilsho	117	12	specification	specification	NN
cord-006229-7yoilsho	117	13	are	be	VBP
cord-006229-7yoilsho	117	14	specifically	specifically	RB
cord-006229-7yoilsho	117	15	regulated	regulate	VBN
cord-006229-7yoilsho	117	16	by	by	IN
cord-006229-7yoilsho	117	17	muscarinic	muscarinic	JJ
cord-006229-7yoilsho	117	18	M3	M3	NNP
cord-006229-7yoilsho	117	19	receptors	receptor	NNS
cord-006229-7yoilsho	117	20	,	,	,
cord-006229-7yoilsho	117	21	while	while	IN
cord-006229-7yoilsho	117	22	M2	M2	NNP
cord-006229-7yoilsho	117	23	receptors	receptor	NNS
cord-006229-7yoilsho	117	24	appear	appear	VBP
cord-006229-7yoilsho	117	25	to	to	TO
cord-006229-7yoilsho	117	26	exert	exert	VB
cord-006229-7yoilsho	117	27	a	a	DT
cord-006229-7yoilsho	117	28	heart	heart	NN
cord-006229-7yoilsho	117	29	-	-	HYPH
cord-006229-7yoilsho	117	30	specific	specific	JJ
cord-006229-7yoilsho	117	31	function	function	NN
cord-006229-7yoilsho	117	32	only	only	RB
cord-006229-7yoilsho	117	33	at	at	IN
cord-006229-7yoilsho	117	34	later	later	JJ
cord-006229-7yoilsho	117	35	stages	stage	NNS
cord-006229-7yoilsho	117	36	.	.	.
cord-006229-7yoilsho	118	1	Continuous	continuous	JJ
cord-006229-7yoilsho	118	2	M3	m3	NN
cord-006229-7yoilsho	118	3	blockage	blockage	NN
cord-006229-7yoilsho	118	4	renders	render	VBZ
cord-006229-7yoilsho	118	5	zebrafish	zebrafish	NN
cord-006229-7yoilsho	118	6	with	with	IN
cord-006229-7yoilsho	118	7	greatly	greatly	RB
cord-006229-7yoilsho	118	8	altered	alter	VBN
cord-006229-7yoilsho	118	9	cardiac	cardiac	JJ
cord-006229-7yoilsho	118	10	morphology	morphology	NN
cord-006229-7yoilsho	118	11	,	,	,
cord-006229-7yoilsho	118	12	particularly	particularly	RB
cord-006229-7yoilsho	118	13	of	of	IN
cord-006229-7yoilsho	118	14	the	the	DT
cord-006229-7yoilsho	118	15	conduction	conduction	NN
cord-006229-7yoilsho	118	16	system	system	NN
cord-006229-7yoilsho	118	17	.	.	.
cord-006229-7yoilsho	119	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	119	2	,	,	,
cord-006229-7yoilsho	119	3	embryos	embryo	NNS
cord-006229-7yoilsho	119	4	with	with	IN
cord-006229-7yoilsho	119	5	M3	M3	NNP
cord-006229-7yoilsho	119	6	inhibition	inhibition	NN
cord-006229-7yoilsho	119	7	display	display	NN
cord-006229-7yoilsho	119	8	impaired	impair	VBD
cord-006229-7yoilsho	119	9	ventricular	ventricular	JJ
cord-006229-7yoilsho	119	10	function	function	NN
cord-006229-7yoilsho	119	11	most	most	RBS
cord-006229-7yoilsho	119	12	likely	likely	JJ
cord-006229-7yoilsho	119	13	due	due	IN
cord-006229-7yoilsho	119	14	to	to	IN
cord-006229-7yoilsho	119	15	an	an	DT
cord-006229-7yoilsho	119	16	AV	av	NN
cord-006229-7yoilsho	119	17	-	-	HYPH
cord-006229-7yoilsho	119	18	block	block	NN
cord-006229-7yoilsho	119	19	and	and	CC
cord-006229-7yoilsho	119	20	substantial	substantial	JJ
cord-006229-7yoilsho	119	21	arrhythmia	arrhythmia	NN
cord-006229-7yoilsho	119	22	in	in	IN
cord-006229-7yoilsho	119	23	the	the	DT
cord-006229-7yoilsho	119	24	atrium	atrium	NN
cord-006229-7yoilsho	119	25	.	.	.
cord-006229-7yoilsho	120	1	Importantly	importantly	RB
cord-006229-7yoilsho	120	2	,	,	,
cord-006229-7yoilsho	120	3	to	to	TO
cord-006229-7yoilsho	120	4	observe	observe	VB
cord-006229-7yoilsho	120	5	these	these	DT
cord-006229-7yoilsho	120	6	phenotypes	phenotype	NNS
cord-006229-7yoilsho	120	7	it	-PRON-	PRP
cord-006229-7yoilsho	120	8	was	be	VBD
cord-006229-7yoilsho	120	9	sufficient	sufficient	JJ
cord-006229-7yoilsho	120	10	to	to	TO
cord-006229-7yoilsho	120	11	block	block	VB
cord-006229-7yoilsho	120	12	M3	M3	NNP
cord-006229-7yoilsho	120	13	receptors	receptor	NNS
cord-006229-7yoilsho	120	14	during	during	IN
cord-006229-7yoilsho	120	15	stages	stage	NNS
cord-006229-7yoilsho	120	16	of	of	IN
cord-006229-7yoilsho	120	17	cardiac	cardiac	JJ
cord-006229-7yoilsho	120	18	differentiation	differentiation	NN
cord-006229-7yoilsho	120	19	,	,	,
cord-006229-7yoilsho	120	20	which	which	WDT
cord-006229-7yoilsho	120	21	is	be	VBZ
cord-006229-7yoilsho	120	22	long	long	RB
cord-006229-7yoilsho	120	23	before	before	IN
cord-006229-7yoilsho	120	24	a	a	DT
cord-006229-7yoilsho	120	25	heart	heart	NN
cord-006229-7yoilsho	120	26	tube	tube	NN
cord-006229-7yoilsho	120	27	has	have	VBZ
cord-006229-7yoilsho	120	28	formed	form	VBN
cord-006229-7yoilsho	120	29	.	.	.
cord-006229-7yoilsho	121	1	We	-PRON-	PRP
cord-006229-7yoilsho	121	2	corroborated	corroborate	VBD
cord-006229-7yoilsho	121	3	our	-PRON-	PRP$
cord-006229-7yoilsho	121	4	findings	finding	NNS
cord-006229-7yoilsho	121	5	regarding	regard	VBG
cord-006229-7yoilsho	121	6	these	these	DT
cord-006229-7yoilsho	121	7	morphological	morphological	JJ
cord-006229-7yoilsho	121	8	changes	change	NNS
cord-006229-7yoilsho	121	9	using	use	VBG
cord-006229-7yoilsho	121	10	marker	marker	NN
cord-006229-7yoilsho	121	11	gene	gene	NN
cord-006229-7yoilsho	121	12	analysis	analysis	NN
cord-006229-7yoilsho	121	13	.	.	.
cord-006229-7yoilsho	122	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	122	2	,	,	,
cord-006229-7yoilsho	122	3	we	-PRON-	PRP
cord-006229-7yoilsho	122	4	obtained	obtain	VBD
cord-006229-7yoilsho	122	5	evidence	evidence	NN
cord-006229-7yoilsho	122	6	for	for	IN
cord-006229-7yoilsho	122	7	M3	M3	NNP
cord-006229-7yoilsho	122	8	receptors	receptor	NNS
cord-006229-7yoilsho	122	9	preventing	prevent	VBG
cord-006229-7yoilsho	122	10	a	a	DT
cord-006229-7yoilsho	122	11	transcriptional	transcriptional	JJ
cord-006229-7yoilsho	122	12	program	program	NN
cord-006229-7yoilsho	122	13	towards	towards	IN
cord-006229-7yoilsho	122	14	the	the	DT
cord-006229-7yoilsho	122	15	induction	induction	NN
cord-006229-7yoilsho	122	16	of	of	IN
cord-006229-7yoilsho	122	17	pacemaker	pacemaker	NN
cord-006229-7yoilsho	122	18	cells	cell	NNS
cord-006229-7yoilsho	122	19	at	at	IN
cord-006229-7yoilsho	122	20	the	the	DT
cord-006229-7yoilsho	122	21	expense	expense	NN
cord-006229-7yoilsho	122	22	of	of	IN
cord-006229-7yoilsho	122	23	AV	av	NN
cord-006229-7yoilsho	122	24	canal	canal	NN
cord-006229-7yoilsho	122	25	cells	cell	NNS
cord-006229-7yoilsho	122	26	.	.	.
cord-006229-7yoilsho	123	1	Importantly	importantly	RB
cord-006229-7yoilsho	123	2	,	,	,
cord-006229-7yoilsho	123	3	this	this	DT
cord-006229-7yoilsho	123	4	is	be	VBZ
cord-006229-7yoilsho	123	5	not	not	RB
cord-006229-7yoilsho	123	6	only	only	RB
cord-006229-7yoilsho	123	7	true	true	JJ
cord-006229-7yoilsho	123	8	during	during	IN
cord-006229-7yoilsho	123	9	heart	heart	NN
cord-006229-7yoilsho	123	10	development	development	NN
cord-006229-7yoilsho	123	11	.	.	.
cord-006229-7yoilsho	124	1	A	a	DT
cord-006229-7yoilsho	124	2	pacemaker	pacemaker	NN
cord-006229-7yoilsho	124	3	program	program	NN
cord-006229-7yoilsho	124	4	is	be	VBZ
cord-006229-7yoilsho	124	5	also	also	RB
cord-006229-7yoilsho	124	6	induced	induce	VBN
cord-006229-7yoilsho	124	7	in	in	IN
cord-006229-7yoilsho	124	8	adult	adult	NN
cord-006229-7yoilsho	124	9	hearts	heart	NNS
cord-006229-7yoilsho	124	10	upon	upon	IN
cord-006229-7yoilsho	124	11	M3	M3	NNP
cord-006229-7yoilsho	124	12	inhibition	inhibition	NN
cord-006229-7yoilsho	124	13	.	.	.
cord-006229-7yoilsho	125	1	Taken	take	VBN
cord-006229-7yoilsho	125	2	together	together	RB
cord-006229-7yoilsho	125	3	,	,	,
cord-006229-7yoilsho	125	4	we	-PRON-	PRP
cord-006229-7yoilsho	125	5	postulate	postulate	VBP
cord-006229-7yoilsho	125	6	that	that	IN
cord-006229-7yoilsho	125	7	muscarinic	muscarinic	JJ
cord-006229-7yoilsho	125	8	M3	M3	NNP
cord-006229-7yoilsho	125	9	receptors	receptor	NNS
cord-006229-7yoilsho	125	10	confine	confine	VBP
cord-006229-7yoilsho	125	11	a	a	DT
cord-006229-7yoilsho	125	12	pacemaker	pacemaker	NN
cord-006229-7yoilsho	125	13	lineage	lineage	NN
cord-006229-7yoilsho	125	14	during	during	IN
cord-006229-7yoilsho	125	15	early	early	JJ
cord-006229-7yoilsho	125	16	steps	step	NNS
cord-006229-7yoilsho	125	17	of	of	IN
cord-006229-7yoilsho	125	18	heart	heart	NN
cord-006229-7yoilsho	125	19	development	development	NN
cord-006229-7yoilsho	125	20	as	as	RB
cord-006229-7yoilsho	125	21	well	well	RB
cord-006229-7yoilsho	125	22	as	as	IN
cord-006229-7yoilsho	125	23	in	in	IN
cord-006229-7yoilsho	125	24	the	the	DT
cord-006229-7yoilsho	125	25	adult	adult	NN
cord-006229-7yoilsho	125	26	heart	heart	NN
cord-006229-7yoilsho	125	27	.	.	.
cord-006229-7yoilsho	126	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	126	2	data	data	NN
cord-006229-7yoilsho	126	3	suggests	suggest	VBZ
cord-006229-7yoilsho	126	4	M3	M3	NNP
cord-006229-7yoilsho	126	5	receptors	receptor	NNS
cord-006229-7yoilsho	126	6	as	as	IN
cord-006229-7yoilsho	126	7	potential	potential	JJ
cord-006229-7yoilsho	126	8	new	new	JJ
cord-006229-7yoilsho	126	9	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	126	10	targets	target	NNS
cord-006229-7yoilsho	126	11	for	for	IN
cord-006229-7yoilsho	126	12	the	the	DT
cord-006229-7yoilsho	126	13	regeneration	regeneration	NN
cord-006229-7yoilsho	126	14	of	of	IN
cord-006229-7yoilsho	126	15	hearts	heart	NNS
cord-006229-7yoilsho	126	16	with	with	IN
cord-006229-7yoilsho	126	17	an	an	DT
cord-006229-7yoilsho	126	18	injured	injure	VBN
cord-006229-7yoilsho	126	19	sinoatrial	sinoatrial	NN
cord-006229-7yoilsho	126	20	node	node	NN
cord-006229-7yoilsho	126	21	.	.	.
cord-006229-7yoilsho	127	1	Systemic	systemic	JJ
cord-006229-7yoilsho	127	2	inhibition	inhibition	NN
cord-006229-7yoilsho	127	3	of	of	IN
cord-006229-7yoilsho	127	4	miR-21	miR-21	NNP
cord-006229-7yoilsho	127	5	has	have	VBZ
cord-006229-7yoilsho	127	6	proved	prove	VBN
cord-006229-7yoilsho	127	7	effective	effective	JJ
cord-006229-7yoilsho	127	8	against	against	IN
cord-006229-7yoilsho	127	9	fibrosis	fibrosis	NN
cord-006229-7yoilsho	127	10	of	of	IN
cord-006229-7yoilsho	127	11	the	the	DT
cord-006229-7yoilsho	127	12	myocardium	myocardium	NN
cord-006229-7yoilsho	127	13	and	and	CC
cord-006229-7yoilsho	127	14	in	in	IN
cord-006229-7yoilsho	127	15	other	other	JJ
cord-006229-7yoilsho	127	16	organs	organ	NNS
cord-006229-7yoilsho	127	17	.	.	.
cord-006229-7yoilsho	128	1	MiR-21	MiR-21	NNP
cord-006229-7yoilsho	128	2	has	have	VBZ
cord-006229-7yoilsho	128	3	been	be	VBN
cord-006229-7yoilsho	128	4	reported	report	VBN
cord-006229-7yoilsho	128	5	to	to	TO
cord-006229-7yoilsho	128	6	exert	exert	VB
cord-006229-7yoilsho	128	7	detrimental	detrimental	JJ
cord-006229-7yoilsho	128	8	effects	effect	NNS
cord-006229-7yoilsho	128	9	in	in	IN
cord-006229-7yoilsho	128	10	cardiac	cardiac	JJ
cord-006229-7yoilsho	128	11	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	128	12	and	and	CC
cord-006229-7yoilsho	128	13	protective	protective	JJ
cord-006229-7yoilsho	128	14	roles	role	NNS
cord-006229-7yoilsho	128	15	in	in	IN
cord-006229-7yoilsho	128	16	cardiac	cardiac	JJ
cord-006229-7yoilsho	128	17	myocytes	myocyte	NNS
cord-006229-7yoilsho	128	18	and	and	CC
cord-006229-7yoilsho	128	19	other	other	JJ
cord-006229-7yoilsho	128	20	myocardial	myocardial	JJ
cord-006229-7yoilsho	128	21	cell	cell	NN
cord-006229-7yoilsho	128	22	types	type	NNS
cord-006229-7yoilsho	128	23	.	.	.
cord-006229-7yoilsho	129	1	A	a	DT
cord-006229-7yoilsho	129	2	better	well	JJR
cord-006229-7yoilsho	129	3	definition	definition	NN
cord-006229-7yoilsho	129	4	of	of	IN
cord-006229-7yoilsho	129	5	the	the	DT
cord-006229-7yoilsho	129	6	cell	cell	NN
cord-006229-7yoilsho	129	7	types	type	NNS
cord-006229-7yoilsho	129	8	that	that	WDT
cord-006229-7yoilsho	129	9	contribute	contribute	VBP
cord-006229-7yoilsho	129	10	to	to	IN
cord-006229-7yoilsho	129	11	the	the	DT
cord-006229-7yoilsho	129	12	beneficial	beneficial	JJ
cord-006229-7yoilsho	129	13	effects	effect	NNS
cord-006229-7yoilsho	129	14	of	of	IN
cord-006229-7yoilsho	129	15	inhibiting	inhibit	VBG
cord-006229-7yoilsho	129	16	miR-21	mir-21	JJ
cord-006229-7yoilsho	129	17	in	in	IN
cord-006229-7yoilsho	129	18	vivo	vivo	NNP
cord-006229-7yoilsho	129	19	may	may	MD
cord-006229-7yoilsho	129	20	aid	aid	VB
cord-006229-7yoilsho	129	21	the	the	DT
cord-006229-7yoilsho	129	22	development	development	NN
cord-006229-7yoilsho	129	23	of	of	IN
cord-006229-7yoilsho	129	24	strategies	strategy	NNS
cord-006229-7yoilsho	129	25	with	with	IN
cord-006229-7yoilsho	129	26	enhanced	enhanced	JJ
cord-006229-7yoilsho	129	27	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	129	28	efficacy	efficacy	NN
cord-006229-7yoilsho	129	29	.	.	.
cord-006229-7yoilsho	130	1	Thus	thus	RB
cord-006229-7yoilsho	130	2	far	far	RB
cord-006229-7yoilsho	130	3	,	,	,
cord-006229-7yoilsho	130	4	no	no	DT
cord-006229-7yoilsho	130	5	approach	approach	NN
cord-006229-7yoilsho	130	6	to	to	TO
cord-006229-7yoilsho	130	7	selectively	selectively	RB
cord-006229-7yoilsho	130	8	manipulate	manipulate	VB
cord-006229-7yoilsho	130	9	microRNAs	microrna	NNS
cord-006229-7yoilsho	130	10	in	in	IN
cord-006229-7yoilsho	130	11	the	the	DT
cord-006229-7yoilsho	130	12	non	non	JJ
cord-006229-7yoilsho	130	13	-	-	JJ
cord-006229-7yoilsho	130	14	myocyte	myocyte	JJ
cord-006229-7yoilsho	130	15	population	population	NN
cord-006229-7yoilsho	130	16	of	of	IN
cord-006229-7yoilsho	130	17	cardiac	cardiac	JJ
cord-006229-7yoilsho	130	18	cells	cell	NNS
cord-006229-7yoilsho	130	19	in	in	IN
cord-006229-7yoilsho	130	20	vivo	vivo	NN
cord-006229-7yoilsho	130	21	has	have	VBZ
cord-006229-7yoilsho	130	22	been	be	VBN
cord-006229-7yoilsho	130	23	available	available	JJ
cord-006229-7yoilsho	130	24	.	.	.
cord-006229-7yoilsho	131	1	In	in	IN
cord-006229-7yoilsho	131	2	this	this	DT
cord-006229-7yoilsho	131	3	study	study	NN
cord-006229-7yoilsho	131	4	,	,	,
cord-006229-7yoilsho	131	5	we	-PRON-	PRP
cord-006229-7yoilsho	131	6	developed	develop	VBD
cord-006229-7yoilsho	131	7	an	an	DT
cord-006229-7yoilsho	131	8	iCre	icre	RB
cord-006229-7yoilsho	131	9	-	-	HYPH
cord-006229-7yoilsho	131	10	encoding	encode	VBG
cord-006229-7yoilsho	131	11	MML	MML	NNP
cord-006229-7yoilsho	131	12	virus	virus	NN
cord-006229-7yoilsho	131	13	for	for	IN
cord-006229-7yoilsho	131	14	application	application	NN
cord-006229-7yoilsho	131	15	in	in	IN
cord-006229-7yoilsho	131	16	miR-21	miR-21	NNP
cord-006229-7yoilsho	131	17	fl	fl	NNP
cord-006229-7yoilsho	131	18	/	/	SYM
cord-006229-7yoilsho	131	19	fl	fl	NNP
cord-006229-7yoilsho	131	20	mice	mouse	NNS
cord-006229-7yoilsho	131	21	.	.	.
cord-006229-7yoilsho	132	1	Delivery	delivery	NN
cord-006229-7yoilsho	132	2	of	of	IN
cord-006229-7yoilsho	132	3	this	this	DT
cord-006229-7yoilsho	132	4	vector	vector	NN
cord-006229-7yoilsho	132	5	to	to	IN
cord-006229-7yoilsho	132	6	neonates	neonate	NNS
cord-006229-7yoilsho	132	7	achieved	achieve	VBN
cord-006229-7yoilsho	132	8	targeted	target	VBN
cord-006229-7yoilsho	132	9	genetic	genetic	JJ
cord-006229-7yoilsho	132	10	ablation	ablation	NN
cord-006229-7yoilsho	132	11	of	of	IN
cord-006229-7yoilsho	132	12	miR-21	miR-21	NNP
cord-006229-7yoilsho	132	13	in	in	IN
cord-006229-7yoilsho	132	14	non	non	JJ
cord-006229-7yoilsho	132	15	-	-	JJ
cord-006229-7yoilsho	132	16	myocyte	myocyte	JJ
cord-006229-7yoilsho	132	17	cardiac	cardiac	NN
cord-006229-7yoilsho	132	18	cells	cell	NNS
cord-006229-7yoilsho	132	19	.	.	.
cord-006229-7yoilsho	133	1	Immunohistochemistry	immunohistochemistry	NN
cord-006229-7yoilsho	133	2	and	and	CC
cord-006229-7yoilsho	133	3	flow	flow	VB
cord-006229-7yoilsho	133	4	cytometry	cytometry	NN
cord-006229-7yoilsho	133	5	confirmed	confirm	VBD
cord-006229-7yoilsho	133	6	that	that	IN
cord-006229-7yoilsho	133	7	MMLV	MMLV	NNP
cord-006229-7yoilsho	133	8	was	be	VBD
cord-006229-7yoilsho	133	9	highly	highly	RB
cord-006229-7yoilsho	133	10	selective	selective	JJ
cord-006229-7yoilsho	133	11	and	and	CC
cord-006229-7yoilsho	133	12	effective	effective	JJ
cord-006229-7yoilsho	133	13	for	for	IN
cord-006229-7yoilsho	133	14	cardiac	cardiac	JJ
cord-006229-7yoilsho	133	15	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	133	16	and	and	CC
cord-006229-7yoilsho	133	17	endothelial	endothelial	JJ
cord-006229-7yoilsho	133	18	cells	cell	NNS
cord-006229-7yoilsho	133	19	.	.	.
cord-006229-7yoilsho	134	1	In	in	IN
cord-006229-7yoilsho	134	2	parallel	parallel	NN
cord-006229-7yoilsho	134	3	,	,	,
cord-006229-7yoilsho	134	4	an	an	DT
cord-006229-7yoilsho	134	5	AAV9-iCre	AAV9-iCre	NNP
cord-006229-7yoilsho	134	6	vector	vector	NN
cord-006229-7yoilsho	134	7	allowed	allow	VBN
cord-006229-7yoilsho	134	8	for	for	IN
cord-006229-7yoilsho	134	9	specific	specific	JJ
cord-006229-7yoilsho	134	10	and	and	CC
cord-006229-7yoilsho	134	11	almost	almost	RB
cord-006229-7yoilsho	134	12	complete	complete	JJ
cord-006229-7yoilsho	134	13	deletion	deletion	NN
cord-006229-7yoilsho	134	14	of	of	IN
cord-006229-7yoilsho	134	15	miR-21	mir-21	DT
cord-006229-7yoilsho	134	16	in	in	IN
cord-006229-7yoilsho	134	17	cardiac	cardiac	JJ
cord-006229-7yoilsho	134	18	myocytes	myocyte	NNS
cord-006229-7yoilsho	134	19	.	.	.
cord-006229-7yoilsho	135	1	When	when	WRB
cord-006229-7yoilsho	135	2	tested	test	VBN
cord-006229-7yoilsho	135	3	in	in	IN
cord-006229-7yoilsho	135	4	a	a	DT
cord-006229-7yoilsho	135	5	model	model	NN
cord-006229-7yoilsho	135	6	for	for	IN
cord-006229-7yoilsho	135	7	chronic	chronic	JJ
cord-006229-7yoilsho	135	8	left	left	JJ
cord-006229-7yoilsho	135	9	ventricular	ventricular	JJ
cord-006229-7yoilsho	135	10	pressure	pressure	NN
cord-006229-7yoilsho	135	11	overload	overload	NN
cord-006229-7yoilsho	135	12	,	,	,
cord-006229-7yoilsho	135	13	MMLV	MMLV	NNP
cord-006229-7yoilsho	135	14	-	-	HYPH
cord-006229-7yoilsho	135	15	iCremediated	iCremediated	NNP
cord-006229-7yoilsho	135	16	deletion	deletion	NN
cord-006229-7yoilsho	135	17	of	of	IN
cord-006229-7yoilsho	135	18	miR-21	mir-21	DT
cord-006229-7yoilsho	135	19	in	in	IN
cord-006229-7yoilsho	135	20	cardiac	cardiac	JJ
cord-006229-7yoilsho	135	21	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	135	22	and	and	CC
cord-006229-7yoilsho	135	23	endothelial	endothelial	JJ
cord-006229-7yoilsho	135	24	cells	cell	NNS
cord-006229-7yoilsho	135	25	significantly	significantly	RB
cord-006229-7yoilsho	135	26	reduced	reduce	VBD
cord-006229-7yoilsho	135	27	cardiac	cardiac	JJ
cord-006229-7yoilsho	135	28	fibrosis	fibrosis	NN
cord-006229-7yoilsho	135	29	and	and	CC
cord-006229-7yoilsho	135	30	hypertrophy	hypertrophy	NN
cord-006229-7yoilsho	135	31	and	and	CC
cord-006229-7yoilsho	135	32	improved	improved	JJ
cord-006229-7yoilsho	135	33	cardiac	cardiac	JJ
cord-006229-7yoilsho	135	34	function	function	NN
cord-006229-7yoilsho	135	35	.	.	.
cord-006229-7yoilsho	136	1	The	the	DT
cord-006229-7yoilsho	136	2	benefit	benefit	NN
cord-006229-7yoilsho	136	3	of	of	IN
cord-006229-7yoilsho	136	4	this	this	DT
cord-006229-7yoilsho	136	5	cell	cell	NN
cord-006229-7yoilsho	136	6	-	-	HYPH
cord-006229-7yoilsho	136	7	type	type	NN
cord-006229-7yoilsho	136	8	-	-	HYPH
cord-006229-7yoilsho	136	9	specific	specific	JJ
cord-006229-7yoilsho	136	10	inhibition	inhibition	NN
cord-006229-7yoilsho	136	11	exceeded	exceed	VBD
cord-006229-7yoilsho	136	12	that	that	WDT
cord-006229-7yoilsho	136	13	observed	observe	VBD
cord-006229-7yoilsho	136	14	upon	upon	IN
cord-006229-7yoilsho	136	15	global	global	JJ
cord-006229-7yoilsho	136	16	genetic	genetic	JJ
cord-006229-7yoilsho	136	17	deletion	deletion	NN
cord-006229-7yoilsho	136	18	of	of	IN
cord-006229-7yoilsho	136	19	the	the	DT
cord-006229-7yoilsho	136	20	miR-21	mir-21	JJ
cord-006229-7yoilsho	136	21	gene	gene	NN
cord-006229-7yoilsho	136	22	in	in	IN
cord-006229-7yoilsho	136	23	mice	mouse	NNS
cord-006229-7yoilsho	136	24	.	.	.
cord-006229-7yoilsho	137	1	AAV9-mediated	aav9-mediated	JJ
cord-006229-7yoilsho	137	2	deletion	deletion	NN
cord-006229-7yoilsho	137	3	of	of	IN
cord-006229-7yoilsho	137	4	miR-21	miR-21	NNP
cord-006229-7yoilsho	137	5	,	,	,
cord-006229-7yoilsho	137	6	albeit	albeit	IN
cord-006229-7yoilsho	137	7	lowering	lower	VBG
cord-006229-7yoilsho	137	8	cardiac	cardiac	JJ
cord-006229-7yoilsho	137	9	hypertrophy	hypertrophy	NN
cord-006229-7yoilsho	137	10	,	,	,
cord-006229-7yoilsho	137	11	had	have	VBD
cord-006229-7yoilsho	137	12	no	no	DT
cord-006229-7yoilsho	137	13	effect	effect	NN
cord-006229-7yoilsho	137	14	on	on	IN
cord-006229-7yoilsho	137	15	fibrosis	fibrosis	NN
cord-006229-7yoilsho	137	16	or	or	CC
cord-006229-7yoilsho	137	17	cardiac	cardiac	JJ
cord-006229-7yoilsho	137	18	function	function	NN
cord-006229-7yoilsho	137	19	.	.	.
cord-006229-7yoilsho	138	1	Taken	take	VBN
cord-006229-7yoilsho	138	2	together	together	RB
cord-006229-7yoilsho	138	3	,	,	,
cord-006229-7yoilsho	138	4	neonatal	neonatal	JJ
cord-006229-7yoilsho	138	5	delivery	delivery	NN
cord-006229-7yoilsho	138	6	of	of	IN
cord-006229-7yoilsho	138	7	engineered	engineer	VBN
cord-006229-7yoilsho	138	8	iCre	icre	JJ
cord-006229-7yoilsho	138	9	-	-	HYPH
cord-006229-7yoilsho	138	10	encoding	encode	VBG
cord-006229-7yoilsho	138	11	viruses	virus	NNS
cord-006229-7yoilsho	138	12	enabled	enable	VBN
cord-006229-7yoilsho	138	13	for	for	IN
cord-006229-7yoilsho	138	14	the	the	DT
cord-006229-7yoilsho	138	15	first	first	JJ
cord-006229-7yoilsho	138	16	time	time	NN
cord-006229-7yoilsho	138	17	a	a	DT
cord-006229-7yoilsho	138	18	differential	differential	JJ
cord-006229-7yoilsho	138	19	gene	gene	NN
cord-006229-7yoilsho	138	20	targeting	target	VBG
cord-006229-7yoilsho	138	21	in	in	IN
cord-006229-7yoilsho	138	22	non	non	JJ
cord-006229-7yoilsho	138	23	-	-	JJ
cord-006229-7yoilsho	138	24	myocyte	myocyte	JJ
cord-006229-7yoilsho	138	25	and	and	CC
cord-006229-7yoilsho	138	26	myocyte	myocyte	NNP
cord-006229-7yoilsho	138	27	cells	cell	NNS
cord-006229-7yoilsho	138	28	in	in	IN
cord-006229-7yoilsho	138	29	myocardium	myocardium	NN
cord-006229-7yoilsho	138	30	.	.	.
cord-006229-7yoilsho	139	1	Non	non	JJ
cord-006229-7yoilsho	139	2	-	-	JJ
cord-006229-7yoilsho	139	3	myocyte	myocyte	JJ
cord-006229-7yoilsho	139	4	deletion	deletion	NN
cord-006229-7yoilsho	139	5	of	of	IN
cord-006229-7yoilsho	139	6	miR-21	miR-21	NNP
cord-006229-7yoilsho	139	7	demonstrated	demonstrate	VBN
cord-006229-7yoilsho	139	8	that	that	IN
cord-006229-7yoilsho	139	9	miR-21	miR-21	NNP
cord-006229-7yoilsho	139	10	exerts	exert	VBZ
cord-006229-7yoilsho	139	11	its	-PRON-	PRP$
cord-006229-7yoilsho	139	12	cardiac	cardiac	JJ
cord-006229-7yoilsho	139	13	profibrotic	profibrotic	JJ
cord-006229-7yoilsho	139	14	activity	activity	NN
cord-006229-7yoilsho	139	15	directly	directly	RB
cord-006229-7yoilsho	139	16	in	in	IN
cord-006229-7yoilsho	139	17	cardiac	cardiac	JJ
cord-006229-7yoilsho	139	18	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	139	19	and	and	CC
cord-006229-7yoilsho	139	20	in	in	IN
cord-006229-7yoilsho	139	21	endothelial	endothelial	JJ
cord-006229-7yoilsho	139	22	cells	cell	NNS
cord-006229-7yoilsho	139	23	.	.	.
cord-006229-7yoilsho	140	1	This	this	DT
cord-006229-7yoilsho	140	2	novel	novel	NN
cord-006229-7yoilsho	140	3	finding	finding	NN
cord-006229-7yoilsho	140	4	should	should	MD
cord-006229-7yoilsho	140	5	encourage	encourage	VB
cord-006229-7yoilsho	140	6	tailoring	tailoring	NN
cord-006229-7yoilsho	140	7	of	of	IN
cord-006229-7yoilsho	140	8	antimiR-21	antimir-21	DT
cord-006229-7yoilsho	140	9	therapy	therapy	NN
cord-006229-7yoilsho	140	10	towards	towards	IN
cord-006229-7yoilsho	140	11	cellular	cellular	JJ
cord-006229-7yoilsho	140	12	tropism	tropism	NN
cord-006229-7yoilsho	140	13	.	.	.
cord-006229-7yoilsho	141	1	Chronic	chronic	JJ
cord-006229-7yoilsho	141	2	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	141	3	diseases	disease	NNS
cord-006229-7yoilsho	141	4	,	,	,
cord-006229-7yoilsho	141	5	such	such	JJ
cord-006229-7yoilsho	141	6	as	as	IN
cord-006229-7yoilsho	141	7	psoriasis	psoriasis	NN
cord-006229-7yoilsho	141	8	or	or	CC
cord-006229-7yoilsho	141	9	rheumatoid	rheumatoid	NN
cord-006229-7yoilsho	141	10	arthritis	arthritis	NN
cord-006229-7yoilsho	141	11	,	,	,
cord-006229-7yoilsho	141	12	are	be	VBP
cord-006229-7yoilsho	141	13	characterized	characterize	VBN
cord-006229-7yoilsho	141	14	by	by	IN
cord-006229-7yoilsho	141	15	constant	constant	JJ
cord-006229-7yoilsho	141	16	leukocyte	leukocyte	NN
cord-006229-7yoilsho	141	17	infiltration	infiltration	NN
cord-006229-7yoilsho	141	18	and	and	CC
cord-006229-7yoilsho	141	19	ongoing	ongoing	JJ
cord-006229-7yoilsho	141	20	angiogenesis	angiogenesis	NN
cord-006229-7yoilsho	141	21	in	in	IN
cord-006229-7yoilsho	141	22	the	the	DT
cord-006229-7yoilsho	141	23	inflamed	inflamed	JJ
cord-006229-7yoilsho	141	24	tissue	tissue	NN
cord-006229-7yoilsho	141	25	.	.	.
cord-006229-7yoilsho	142	1	As	as	IN
cord-006229-7yoilsho	142	2	current	current	JJ
cord-006229-7yoilsho	142	3	anti	anti	JJ
cord-006229-7yoilsho	142	4	-	-	JJ
cord-006229-7yoilsho	142	5	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	142	6	pharmacotherapy	pharmacotherapy	NN
cord-006229-7yoilsho	142	7	is	be	VBZ
cord-006229-7yoilsho	142	8	not	not	RB
cord-006229-7yoilsho	142	9	always	always	RB
cord-006229-7yoilsho	142	10	satisfying	satisfying	JJ
cord-006229-7yoilsho	142	11	,	,	,
cord-006229-7yoilsho	142	12	there	there	EX
cord-006229-7yoilsho	142	13	is	be	VBZ
cord-006229-7yoilsho	142	14	a	a	DT
cord-006229-7yoilsho	142	15	great	great	JJ
cord-006229-7yoilsho	142	16	demand	demand	NN
cord-006229-7yoilsho	142	17	for	for	IN
cord-006229-7yoilsho	142	18	the	the	DT
cord-006229-7yoilsho	142	19	discovery	discovery	NN
cord-006229-7yoilsho	142	20	of	of	IN
cord-006229-7yoilsho	142	21	new	new	JJ
cord-006229-7yoilsho	142	22	drug	drug	NN
cord-006229-7yoilsho	142	23	leads	lead	VBZ
cord-006229-7yoilsho	142	24	as	as	RB
cord-006229-7yoilsho	142	25	well	well	RB
cord-006229-7yoilsho	142	26	as	as	IN
cord-006229-7yoilsho	142	27	novel	novel	JJ
cord-006229-7yoilsho	142	28	drug	drug	NN
cord-006229-7yoilsho	142	29	targets	target	NNS
cord-006229-7yoilsho	142	30	.	.	.
cord-006229-7yoilsho	143	1	The	the	DT
cord-006229-7yoilsho	143	2	synthetic	synthetic	JJ
cord-006229-7yoilsho	143	3	carbazole	carbazole	NN
cord-006229-7yoilsho	143	4	alkaloid	alkaloid	NN
cord-006229-7yoilsho	143	5	derivative	derivative	JJ
cord-006229-7yoilsho	143	6	C81	C81	NNP
cord-006229-7yoilsho	143	7	acts	act	VBZ
cord-006229-7yoilsho	143	8	as	as	IN
cord-006229-7yoilsho	143	9	a	a	DT
cord-006229-7yoilsho	143	10	multikinase	multikinase	NN
cord-006229-7yoilsho	143	11	inhibitor	inhibitor	NN
cord-006229-7yoilsho	143	12	.	.	.
cord-006229-7yoilsho	144	1	Results	result	NNS
cord-006229-7yoilsho	144	2	of	of	IN
cord-006229-7yoilsho	144	3	a	a	DT
cord-006229-7yoilsho	144	4	thermal	thermal	JJ
cord-006229-7yoilsho	144	5	shift	shift	NN
cord-006229-7yoilsho	144	6	assay	assay	NN
cord-006229-7yoilsho	144	7	revealed	reveal	VBD
cord-006229-7yoilsho	144	8	that	that	IN
cord-006229-7yoilsho	144	9	C81	C81	NNP
cord-006229-7yoilsho	144	10	shows	show	NNS
cord-006229-7yoilsho	144	11	by	by	IN
cord-006229-7yoilsho	144	12	far	far	RB
cord-006229-7yoilsho	144	13	the	the	DT
cord-006229-7yoilsho	144	14	highest	high	JJS
cord-006229-7yoilsho	144	15	binding	binding	JJ
cord-006229-7yoilsho	144	16	affinity	affinity	NN
cord-006229-7yoilsho	144	17	to	to	IN
cord-006229-7yoilsho	144	18	the	the	DT
cord-006229-7yoilsho	144	19	BMP-2-inducible	bmp-2-inducible	JJ
cord-006229-7yoilsho	144	20	kinase	kinase	NN
cord-006229-7yoilsho	144	21	(	(	-LRB-
cord-006229-7yoilsho	144	22	BMP2K	BMP2K	NNS
cord-006229-7yoilsho	144	23	/	/	SYM
cord-006229-7yoilsho	144	24	BIKE	bike	NN
cord-006229-7yoilsho	144	25	)	)	-RRB-
cord-006229-7yoilsho	144	26	.	.	.
cord-006229-7yoilsho	145	1	BMP2	BMP2	NNP
cord-006229-7yoilsho	145	2	K	K	NNP
cord-006229-7yoilsho	145	3	represents	represent	VBZ
cord-006229-7yoilsho	145	4	an	an	DT
cord-006229-7yoilsho	145	5	as	as	RB
cord-006229-7yoilsho	145	6	yet	yet	RB
cord-006229-7yoilsho	145	7	largely	largely	RB
cord-006229-7yoilsho	145	8	uncharacterized	uncharacterized	JJ
cord-006229-7yoilsho	145	9	protein	protein	NN
cord-006229-7yoilsho	145	10	,	,	,
cord-006229-7yoilsho	145	11	which	which	WDT
cord-006229-7yoilsho	145	12	is	be	VBZ
cord-006229-7yoilsho	145	13	not	not	RB
cord-006229-7yoilsho	145	14	regulated	regulate	VBN
cord-006229-7yoilsho	145	15	by	by	IN
cord-006229-7yoilsho	145	16	BMP-2	BMP-2	NNP
cord-006229-7yoilsho	145	17	in	in	IN
cord-006229-7yoilsho	145	18	endothelial	endothelial	JJ
cord-006229-7yoilsho	145	19	cells	cell	NNS
cord-006229-7yoilsho	145	20	.	.	.
cord-006229-7yoilsho	146	1	Therefore	therefore	RB
cord-006229-7yoilsho	146	2	,	,	,
cord-006229-7yoilsho	146	3	we	-PRON-	PRP
cord-006229-7yoilsho	146	4	aimed	aim	VBD
cord-006229-7yoilsho	146	5	to	to	TO
cord-006229-7yoilsho	146	6	analyze	analyze	VB
cord-006229-7yoilsho	146	7	(	(	-LRB-
cord-006229-7yoilsho	146	8	i	i	NN
cord-006229-7yoilsho	146	9	)	)	-RRB-
cord-006229-7yoilsho	146	10	the	the	DT
cord-006229-7yoilsho	146	11	pharmacological	pharmacological	JJ
cord-006229-7yoilsho	146	12	potential	potential	NN
cord-006229-7yoilsho	146	13	of	of	IN
cord-006229-7yoilsho	146	14	C81	C81	NNP
cord-006229-7yoilsho	146	15	and	and	CC
cord-006229-7yoilsho	146	16	(	(	-LRB-
cord-006229-7yoilsho	146	17	ii	ii	NN
cord-006229-7yoilsho	146	18	)	)	-RRB-
cord-006229-7yoilsho	147	1	the	the	DT
cord-006229-7yoilsho	147	2	role	role	NN
cord-006229-7yoilsho	147	3	of	of	IN
cord-006229-7yoilsho	147	4	BMP2	BMP2	NNP
cord-006229-7yoilsho	147	5	K	K	NNP
cord-006229-7yoilsho	147	6	in	in	IN
cord-006229-7yoilsho	147	7	angiogenic	angiogenic	JJ
cord-006229-7yoilsho	147	8	and	and	CC
cord-006229-7yoilsho	147	9	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	147	10	processes	process	NNS
cord-006229-7yoilsho	147	11	in	in	IN
cord-006229-7yoilsho	147	12	the	the	DT
cord-006229-7yoilsho	147	13	vascular	vascular	JJ
cord-006229-7yoilsho	147	14	endothelium	endothelium	NN
cord-006229-7yoilsho	147	15	.	.	.
cord-006229-7yoilsho	148	1	Initial	initial	JJ
cord-006229-7yoilsho	148	2	experiments	experiment	NNS
cord-006229-7yoilsho	148	3	show	show	VBP
cord-006229-7yoilsho	148	4	that	that	IN
cord-006229-7yoilsho	148	5	only	only	RB
cord-006229-7yoilsho	148	6	high	high	JJ
cord-006229-7yoilsho	148	7	concentrations	concentration	NNS
cord-006229-7yoilsho	148	8	of	of	IN
cord-006229-7yoilsho	148	9	C81	C81	NNP
cord-006229-7yoilsho	148	10	affected	affect	VBD
cord-006229-7yoilsho	148	11	the	the	DT
cord-006229-7yoilsho	148	12	viability	viability	NN
cord-006229-7yoilsho	148	13	of	of	IN
cord-006229-7yoilsho	148	14	human	human	JJ
cord-006229-7yoilsho	148	15	umbilical	umbilical	JJ
cord-006229-7yoilsho	148	16	vein	vein	NN
cord-006229-7yoilsho	148	17	endothelial	endothelial	JJ
cord-006229-7yoilsho	148	18	cells	cell	NNS
cord-006229-7yoilsho	148	19	(	(	-LRB-
cord-006229-7yoilsho	148	20	HUVECs	huvec	NNS
cord-006229-7yoilsho	148	21	)	)	-RRB-
cord-006229-7yoilsho	148	22	.	.	.
cord-006229-7yoilsho	149	1	Both	both	DT
cord-006229-7yoilsho	149	2	C81	C81	NNP
cord-006229-7yoilsho	149	3	and	and	CC
cord-006229-7yoilsho	149	4	the	the	DT
cord-006229-7yoilsho	149	5	knock	knock	VB
cord-006229-7yoilsho	149	6	-	-	HYPH
cord-006229-7yoilsho	149	7	down	down	NN
cord-006229-7yoilsho	149	8	of	of	IN
cord-006229-7yoilsho	149	9	BM2	BM2	NNP
cord-006229-7yoilsho	149	10	K	K	NNP
cord-006229-7yoilsho	149	11	(	(	-LRB-
cord-006229-7yoilsho	149	12	RNAi	RNAi	NNP
cord-006229-7yoilsho	149	13	)	)	-RRB-
cord-006229-7yoilsho	149	14	reduced	reduce	VBD
cord-006229-7yoilsho	149	15	the	the	DT
cord-006229-7yoilsho	149	16	migratory	migratory	JJ
cord-006229-7yoilsho	149	17	capacity	capacity	NN
cord-006229-7yoilsho	149	18	of	of	IN
cord-006229-7yoilsho	149	19	a	a	DT
cord-006229-7yoilsho	149	20	human	human	JJ
cord-006229-7yoilsho	149	21	microvascular	microvascular	JJ
cord-006229-7yoilsho	149	22	endothelial	endothelial	JJ
cord-006229-7yoilsho	149	23	cell	cell	NN
cord-006229-7yoilsho	149	24	line	line	NN
cord-006229-7yoilsho	149	25	(	(	-LRB-
cord-006229-7yoilsho	149	26	HMEC-1	hmec-1	NN
cord-006229-7yoilsho	149	27	)	)	-RRB-
cord-006229-7yoilsho	149	28	.	.	.
cord-006229-7yoilsho	150	1	Also	also	RB
cord-006229-7yoilsho	150	2	the	the	DT
cord-006229-7yoilsho	150	3	proliferation	proliferation	NN
cord-006229-7yoilsho	150	4	of	of	IN
cord-006229-7yoilsho	150	5	HMEC-1	HMEC-1	NNP
cord-006229-7yoilsho	150	6	was	be	VBD
cord-006229-7yoilsho	150	7	reduced	reduce	VBN
cord-006229-7yoilsho	150	8	by	by	IN
cord-006229-7yoilsho	150	9	C81	C81	NNP
cord-006229-7yoilsho	150	10	treatment	treatment	NN
cord-006229-7yoilsho	150	11	(	(	-LRB-
cord-006229-7yoilsho	150	12	IC	IC	NNP
cord-006229-7yoilsho	150	13	50	50	CD
cord-006229-7yoilsho	150	14	:	:	SYM
cord-006229-7yoilsho	150	15	7	7	CD
cord-006229-7yoilsho	150	16	µM	µm	NN
cord-006229-7yoilsho	150	17	)	)	-RRB-
cord-006229-7yoilsho	150	18	.	.	.
cord-006229-7yoilsho	151	1	A	a	DT
cord-006229-7yoilsho	151	2	tube	tube	NN
cord-006229-7yoilsho	151	3	formation	formation	NN
cord-006229-7yoilsho	151	4	assay	assay	NN
cord-006229-7yoilsho	151	5	on	on	IN
cord-006229-7yoilsho	151	6	Matrigel	Matrigel	NNP
cord-006229-7yoilsho	151	7	demonstrated	demonstrate	VBD
cord-006229-7yoilsho	151	8	that	that	IN
cord-006229-7yoilsho	151	9	C81	C81	NNP
cord-006229-7yoilsho	151	10	significantly	significantly	RB
cord-006229-7yoilsho	151	11	impaired	impair	VBD
cord-006229-7yoilsho	151	12	the	the	DT
cord-006229-7yoilsho	151	13	formation	formation	NN
cord-006229-7yoilsho	151	14	of	of	IN
cord-006229-7yoilsho	151	15	capillary	capillary	JJ
cord-006229-7yoilsho	151	16	-	-	HYPH
cord-006229-7yoilsho	151	17	like	like	JJ
cord-006229-7yoilsho	151	18	structures	structure	NNS
cord-006229-7yoilsho	151	19	in	in	IN
cord-006229-7yoilsho	151	20	a	a	DT
cord-006229-7yoilsho	151	21	dose	dose	NN
cord-006229-7yoilsho	151	22	-	-	HYPH
cord-006229-7yoilsho	151	23	dependent	dependent	JJ
cord-006229-7yoilsho	151	24	manner	manner	NN
cord-006229-7yoilsho	151	25	.	.	.
cord-006229-7yoilsho	152	1	Interestingly	interestingly	RB
cord-006229-7yoilsho	152	2	,	,	,
cord-006229-7yoilsho	152	3	the	the	DT
cord-006229-7yoilsho	152	4	analysis	analysis	NN
cord-006229-7yoilsho	152	5	(	(	-LRB-
cord-006229-7yoilsho	152	6	Western	western	JJ
cord-006229-7yoilsho	152	7	blot	blot	NN
cord-006229-7yoilsho	152	8	)	)	-RRB-
cord-006229-7yoilsho	152	9	of	of	IN
cord-006229-7yoilsho	152	10	signaling	signal	VBG
cord-006229-7yoilsho	152	11	molecules	molecule	NNS
cord-006229-7yoilsho	152	12	in	in	IN
cord-006229-7yoilsho	152	13	HUVECs	huvec	NNS
cord-006229-7yoilsho	152	14	that	that	WDT
cord-006229-7yoilsho	152	15	play	play	VBP
cord-006229-7yoilsho	152	16	a	a	DT
cord-006229-7yoilsho	152	17	crucial	crucial	JJ
cord-006229-7yoilsho	152	18	role	role	NN
cord-006229-7yoilsho	152	19	in	in	IN
cord-006229-7yoilsho	152	20	cell	cell	NN
cord-006229-7yoilsho	152	21	proliferation	proliferation	NN
cord-006229-7yoilsho	152	22	(	(	-LRB-
cord-006229-7yoilsho	152	23	e.g.	e.g.	RB
cord-006229-7yoilsho	152	24	ERK	ERK	NNP
cord-006229-7yoilsho	152	25	,	,	,
cord-006229-7yoilsho	152	26	Akt	Akt	NNP
cord-006229-7yoilsho	152	27	)	)	-RRB-
cord-006229-7yoilsho	152	28	revealed	reveal	VBD
cord-006229-7yoilsho	152	29	that	that	IN
cord-006229-7yoilsho	152	30	these	these	DT
cord-006229-7yoilsho	152	31	pathways	pathway	NNS
cord-006229-7yoilsho	152	32	are	be	VBP
cord-006229-7yoilsho	152	33	not	not	RB
cord-006229-7yoilsho	152	34	influenced	influence	VBN
cord-006229-7yoilsho	152	35	,	,	,
cord-006229-7yoilsho	152	36	neither	neither	CC
cord-006229-7yoilsho	152	37	by	by	IN
cord-006229-7yoilsho	152	38	C81	C81	NNP
cord-006229-7yoilsho	152	39	treatment	treatment	NN
cord-006229-7yoilsho	152	40	nor	nor	CC
cord-006229-7yoilsho	152	41	by	by	IN
cord-006229-7yoilsho	152	42	BMP2	BMP2	NNP
cord-006229-7yoilsho	152	43	K	K	NNP
cord-006229-7yoilsho	152	44	gene	gene	NN
cord-006229-7yoilsho	152	45	silencing	silencing	NN
cord-006229-7yoilsho	152	46	.	.	.
cord-006229-7yoilsho	153	1	In	in	IN
cord-006229-7yoilsho	153	2	regard	regard	NN
cord-006229-7yoilsho	153	3	to	to	IN
cord-006229-7yoilsho	153	4	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	153	5	processes	process	NNS
cord-006229-7yoilsho	153	6	,	,	,
cord-006229-7yoilsho	153	7	C81	C81	NNP
cord-006229-7yoilsho	153	8	treatment	treatment	NN
cord-006229-7yoilsho	153	9	or	or	CC
cord-006229-7yoilsho	153	10	BMP2	BMP2	NNP
cord-006229-7yoilsho	153	11	K	K	NNP
cord-006229-7yoilsho	153	12	silencing	silencing	NN
cord-006229-7yoilsho	153	13	of	of	IN
cord-006229-7yoilsho	153	14	HUVECs	huvec	NNS
cord-006229-7yoilsho	153	15	decreased	decrease	VBD
cord-006229-7yoilsho	153	16	the	the	DT
cord-006229-7yoilsho	153	17	adhesion	adhesion	NN
cord-006229-7yoilsho	153	18	of	of	IN
cord-006229-7yoilsho	153	19	THP-1	THP-1	NNP
cord-006229-7yoilsho	153	20	cells	cell	NNS
cord-006229-7yoilsho	153	21	,	,	,
cord-006229-7yoilsho	153	22	a	a	DT
cord-006229-7yoilsho	153	23	monocytic	monocytic	JJ
cord-006229-7yoilsho	153	24	cell	cell	NN
cord-006229-7yoilsho	153	25	line	line	NN
cord-006229-7yoilsho	153	26	,	,	,
cord-006229-7yoilsho	153	27	onto	onto	IN
cord-006229-7yoilsho	153	28	the	the	DT
cord-006229-7yoilsho	153	29	activated	activate	VBN
cord-006229-7yoilsho	153	30	endothelial	endothelial	JJ
cord-006229-7yoilsho	153	31	cells	cell	NNS
cord-006229-7yoilsho	153	32	.	.	.
cord-006229-7yoilsho	154	1	As	as	IN
cord-006229-7yoilsho	154	2	the	the	DT
cord-006229-7yoilsho	154	3	interaction	interaction	NN
cord-006229-7yoilsho	154	4	of	of	IN
cord-006229-7yoilsho	154	5	leukocytes	leukocyte	NNS
cord-006229-7yoilsho	154	6	is	be	VBZ
cord-006229-7yoilsho	154	7	mainly	mainly	RB
cord-006229-7yoilsho	154	8	mediated	mediate	VBN
cord-006229-7yoilsho	154	9	by	by	IN
cord-006229-7yoilsho	154	10	cell	cell	NN
cord-006229-7yoilsho	154	11	adhesion	adhesion	NN
cord-006229-7yoilsho	154	12	molecules	molecule	NNS
cord-006229-7yoilsho	154	13	(	(	-LRB-
cord-006229-7yoilsho	154	14	CAMs	cam	NNS
cord-006229-7yoilsho	154	15	)	)	-RRB-
cord-006229-7yoilsho	154	16	,	,	,
cord-006229-7yoilsho	154	17	the	the	DT
cord-006229-7yoilsho	154	18	effect	effect	NN
cord-006229-7yoilsho	154	19	of	of	IN
cord-006229-7yoilsho	154	20	C81	C81	NNP
cord-006229-7yoilsho	154	21	or	or	CC
cord-006229-7yoilsho	154	22	BMP2	BMP2	NNP
cord-006229-7yoilsho	154	23	K	K	NNP
cord-006229-7yoilsho	154	24	silencing	silence	VBG
cord-006229-7yoilsho	154	25	on	on	IN
cord-006229-7yoilsho	154	26	their	-PRON-	PRP$
cord-006229-7yoilsho	154	27	expression	expression	NN
cord-006229-7yoilsho	154	28	was	be	VBD
cord-006229-7yoilsho	154	29	analyzed	analyze	VBN
cord-006229-7yoilsho	154	30	(	(	-LRB-
cord-006229-7yoilsho	154	31	flow	flow	NN
cord-006229-7yoilsho	154	32	cytometry	cytometry	NN
cord-006229-7yoilsho	154	33	,	,	,
cord-006229-7yoilsho	154	34	qPCR	qPCR	NNP
cord-006229-7yoilsho	154	35	)	)	-RRB-
cord-006229-7yoilsho	154	36	.	.	.
cord-006229-7yoilsho	155	1	While	while	IN
cord-006229-7yoilsho	155	2	the	the	DT
cord-006229-7yoilsho	155	3	expression	expression	NN
cord-006229-7yoilsho	155	4	of	of	IN
cord-006229-7yoilsho	155	5	CAMs	cam	NNS
cord-006229-7yoilsho	155	6	was	be	VBD
cord-006229-7yoilsho	155	7	strongly	strongly	RB
cord-006229-7yoilsho	155	8	decreased	decrease	VBN
cord-006229-7yoilsho	155	9	after	after	IN
cord-006229-7yoilsho	155	10	C81	C81	NNP
cord-006229-7yoilsho	155	11	treatment	treatment	NN
cord-006229-7yoilsho	155	12	,	,	,
cord-006229-7yoilsho	155	13	the	the	DT
cord-006229-7yoilsho	155	14	knock	knock	VB
cord-006229-7yoilsho	155	15	-	-	HYPH
cord-006229-7yoilsho	155	16	down	down	NN
cord-006229-7yoilsho	155	17	of	of	IN
cord-006229-7yoilsho	155	18	BMP2	BMP2	NNP
cord-006229-7yoilsho	155	19	K	K	NNP
cord-006229-7yoilsho	155	20	did	do	VBD
cord-006229-7yoilsho	155	21	not	not	RB
cord-006229-7yoilsho	155	22	markedly	markedly	RB
cord-006229-7yoilsho	155	23	affect	affect	VB
cord-006229-7yoilsho	155	24	their	-PRON-	PRP$
cord-006229-7yoilsho	155	25	expression	expression	NN
cord-006229-7yoilsho	155	26	.	.	.
cord-006229-7yoilsho	156	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	156	2	,	,	,
cord-006229-7yoilsho	156	3	both	both	DT
cord-006229-7yoilsho	156	4	approaches	approach	NNS
cord-006229-7yoilsho	156	5	did	do	VBD
cord-006229-7yoilsho	156	6	not	not	RB
cord-006229-7yoilsho	156	7	lead	lead	VB
cord-006229-7yoilsho	156	8	to	to	IN
cord-006229-7yoilsho	156	9	the	the	DT
cord-006229-7yoilsho	156	10	reduction	reduction	NN
cord-006229-7yoilsho	156	11	of	of	IN
cord-006229-7yoilsho	156	12	TNF	TNF	NNP
cord-006229-7yoilsho	156	13	-	-	HYPH
cord-006229-7yoilsho	156	14	induced	induce	VBN
cord-006229-7yoilsho	156	15	IκBα	IκBα	NNP
cord-006229-7yoilsho	156	16	degradation	degradation	NN
cord-006229-7yoilsho	156	17	(	(	-LRB-
cord-006229-7yoilsho	156	18	Western	western	JJ
cord-006229-7yoilsho	156	19	blot	blot	NN
cord-006229-7yoilsho	156	20	)	)	-RRB-
cord-006229-7yoilsho	156	21	or	or	CC
cord-006229-7yoilsho	156	22	p65	p65	NN
cord-006229-7yoilsho	156	23	translocation	translocation	NN
cord-006229-7yoilsho	156	24	into	into	IN
cord-006229-7yoilsho	156	25	the	the	DT
cord-006229-7yoilsho	156	26	nucleus	nucleus	NN
cord-006229-7yoilsho	156	27	(	(	-LRB-
cord-006229-7yoilsho	156	28	microscopy	microscopy	NNP
cord-006229-7yoilsho	156	29	)	)	-RRB-
cord-006229-7yoilsho	156	30	.	.	.
cord-006229-7yoilsho	157	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	157	2	study	study	NN
cord-006229-7yoilsho	157	3	provides	provide	VBZ
cord-006229-7yoilsho	157	4	first	first	JJ
cord-006229-7yoilsho	157	5	insights	insight	NNS
cord-006229-7yoilsho	157	6	into	into	IN
cord-006229-7yoilsho	157	7	the	the	DT
cord-006229-7yoilsho	157	8	anti	anti	JJ
cord-006229-7yoilsho	157	9	-	-	JJ
cord-006229-7yoilsho	157	10	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	157	11	and	and	CC
cord-006229-7yoilsho	157	12	anti	anti	JJ
cord-006229-7yoilsho	157	13	-	-	JJ
cord-006229-7yoilsho	157	14	angiogenic	angiogenic	JJ
cord-006229-7yoilsho	157	15	potential	potential	NN
cord-006229-7yoilsho	157	16	of	of	IN
cord-006229-7yoilsho	157	17	the	the	DT
cord-006229-7yoilsho	157	18	carbazole	carbazole	NNP
cord-006229-7yoilsho	157	19	alkaloid	alkaloid	NN
cord-006229-7yoilsho	157	20	derivative	derivative	JJ
cord-006229-7yoilsho	157	21	C81	C81	NNP
cord-006229-7yoilsho	157	22	in	in	IN
cord-006229-7yoilsho	157	23	vitro	vitro	FW
cord-006229-7yoilsho	157	24	.	.	.
cord-006229-7yoilsho	158	1	The	the	DT
cord-006229-7yoilsho	158	2	precise	precise	JJ
cord-006229-7yoilsho	158	3	role	role	NN
cord-006229-7yoilsho	158	4	of	of	IN
cord-006229-7yoilsho	158	5	BMP2	BMP2	NNP
cord-006229-7yoilsho	158	6	K	K	NNP
cord-006229-7yoilsho	158	7	in	in	IN
cord-006229-7yoilsho	158	8	angiogenic	angiogenic	JJ
cord-006229-7yoilsho	158	9	and	and	CC
cord-006229-7yoilsho	158	10	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	158	11	endothelial	endothelial	JJ
cord-006229-7yoilsho	158	12	processes	process	NNS
cord-006229-7yoilsho	158	13	as	as	RB
cord-006229-7yoilsho	158	14	well	well	RB
cord-006229-7yoilsho	158	15	as	as	IN
cord-006229-7yoilsho	158	16	the	the	DT
cord-006229-7yoilsho	158	17	involved	involved	JJ
cord-006229-7yoilsho	158	18	pathways	pathway	NNS
cord-006229-7yoilsho	158	19	during	during	IN
cord-006229-7yoilsho	158	20	BMP2	BMP2	NNP
cord-006229-7yoilsho	158	21	K	K	NNP
cord-006229-7yoilsho	158	22	silencing	silencing	NN
cord-006229-7yoilsho	158	23	and	and	CC
cord-006229-7yoilsho	158	24	C81	C81	NNP
cord-006229-7yoilsho	158	25	treatment	treatment	NN
cord-006229-7yoilsho	158	26	will	will	MD
cord-006229-7yoilsho	158	27	be	be	VB
cord-006229-7yoilsho	158	28	further	further	RB
cord-006229-7yoilsho	158	29	elucidated	elucidate	VBN
cord-006229-7yoilsho	158	30	.	.	.
cord-006229-7yoilsho	159	1	Moreover	moreover	RB
cord-006229-7yoilsho	159	2	,	,	,
cord-006229-7yoilsho	159	3	since	since	IN
cord-006229-7yoilsho	159	4	the	the	DT
cord-006229-7yoilsho	159	5	inhibition	inhibition	NN
cord-006229-7yoilsho	159	6	of	of	IN
cord-006229-7yoilsho	159	7	BMP2	BMP2	NNP
cord-006229-7yoilsho	159	8	K	K	NNP
cord-006229-7yoilsho	159	9	seems	seem	VBZ
cord-006229-7yoilsho	159	10	not	not	RB
cord-006229-7yoilsho	159	11	to	to	TO
cord-006229-7yoilsho	159	12	be	be	VB
cord-006229-7yoilsho	159	13	responsible	responsible	JJ
cord-006229-7yoilsho	159	14	for	for	IN
cord-006229-7yoilsho	159	15	all	all	DT
cord-006229-7yoilsho	159	16	actions	action	NNS
cord-006229-7yoilsho	159	17	of	of	IN
cord-006229-7yoilsho	159	18	C81	C81	NNP
cord-006229-7yoilsho	159	19	,	,	,
cord-006229-7yoilsho	159	20	we	-PRON-	PRP
cord-006229-7yoilsho	159	21	will	will	MD
cord-006229-7yoilsho	159	22	investigate	investigate	VB
cord-006229-7yoilsho	159	23	the	the	DT
cord-006229-7yoilsho	159	24	role	role	NN
cord-006229-7yoilsho	159	25	of	of	IN
cord-006229-7yoilsho	159	26	other	other	JJ
cord-006229-7yoilsho	159	27	kinases	kinase	NNS
cord-006229-7yoilsho	159	28	affected	affect	VBN
cord-006229-7yoilsho	159	29	by	by	IN
cord-006229-7yoilsho	159	30	the	the	DT
cord-006229-7yoilsho	159	31	compound	compound	NN
cord-006229-7yoilsho	159	32	in	in	IN
cord-006229-7yoilsho	159	33	these	these	DT
cord-006229-7yoilsho	159	34	processes	process	NNS
cord-006229-7yoilsho	159	35	.	.	.
cord-006229-7yoilsho	160	1	The	the	DT
cord-006229-7yoilsho	160	2	chemokine	chemokine	NN
cord-006229-7yoilsho	160	3	receptor	receptor	NN
cord-006229-7yoilsho	160	4	CXCR4	cxcr4	NN
cord-006229-7yoilsho	160	5	is	be	VBZ
cord-006229-7yoilsho	160	6	a	a	DT
cord-006229-7yoilsho	160	7	multifunctional	multifunctional	JJ
cord-006229-7yoilsho	160	8	receptor	receptor	NN
cord-006229-7yoilsho	160	9	which	which	WDT
cord-006229-7yoilsho	160	10	is	be	VBZ
cord-006229-7yoilsho	160	11	activated	activate	VBN
cord-006229-7yoilsho	160	12	by	by	IN
cord-006229-7yoilsho	160	13	its	-PRON-	PRP$
cord-006229-7yoilsho	160	14	natural	natural	JJ
cord-006229-7yoilsho	160	15	ligand	ligand	NN
cord-006229-7yoilsho	160	16	C	c	NN
cord-006229-7yoilsho	160	17	-	-	HYPH
cord-006229-7yoilsho	160	18	X	X	NNP
cord-006229-7yoilsho	160	19	-	-	HYPH
cord-006229-7yoilsho	160	20	C	c	NN
cord-006229-7yoilsho	160	21	motif	motif	NN
cord-006229-7yoilsho	160	22	chemokine	chemokine	NN
cord-006229-7yoilsho	160	23	12	12	CD
cord-006229-7yoilsho	160	24	(	(	-LRB-
cord-006229-7yoilsho	160	25	CXCL12	CXCL12	NNP
cord-006229-7yoilsho	160	26	)	)	-RRB-
cord-006229-7yoilsho	160	27	.	.	.
cord-006229-7yoilsho	161	1	CXCR4	CXCR4	NNP
cord-006229-7yoilsho	161	2	seems	seem	VBZ
cord-006229-7yoilsho	161	3	to	to	TO
cord-006229-7yoilsho	161	4	be	be	VB
cord-006229-7yoilsho	161	5	part	part	NN
cord-006229-7yoilsho	161	6	of	of	IN
cord-006229-7yoilsho	161	7	the	the	DT
cord-006229-7yoilsho	161	8	lipopolysaccharide	lipopolysaccharide	NN
cord-006229-7yoilsho	161	9	sensing	sensing	NN
cord-006229-7yoilsho	161	10	complex	complex	NN
cord-006229-7yoilsho	161	11	,	,	,
cord-006229-7yoilsho	161	12	suggesting	suggest	VBG
cord-006229-7yoilsho	161	13	that	that	IN
cord-006229-7yoilsho	161	14	an	an	DT
cord-006229-7yoilsho	161	15	intervention	intervention	NN
cord-006229-7yoilsho	161	16	with	with	IN
cord-006229-7yoilsho	161	17	CXCR4	cxcr4	NN
cord-006229-7yoilsho	161	18	agonists	agonist	NNS
cord-006229-7yoilsho	161	19	or	or	CC
cord-006229-7yoilsho	161	20	antagonists	antagonist	NNS
cord-006229-7yoilsho	161	21	could	could	MD
cord-006229-7yoilsho	161	22	result	result	VB
cord-006229-7yoilsho	161	23	in	in	IN
cord-006229-7yoilsho	161	24	reduced	reduce	VBN
cord-006229-7yoilsho	161	25	TLR4	TLR4	NNP
cord-006229-7yoilsho	161	26	signaling	signaling	NN
cord-006229-7yoilsho	161	27	.	.	.
cord-006229-7yoilsho	162	1	However	however	RB
cord-006229-7yoilsho	162	2	,	,	,
cord-006229-7yoilsho	162	3	the	the	DT
cord-006229-7yoilsho	162	4	role	role	NN
cord-006229-7yoilsho	162	5	of	of	IN
cord-006229-7yoilsho	162	6	CXCR4	CXCR4	NNS
cord-006229-7yoilsho	162	7	and	and	CC
cord-006229-7yoilsho	162	8	the	the	DT
cord-006229-7yoilsho	162	9	influence	influence	NN
cord-006229-7yoilsho	162	10	of	of	IN
cord-006229-7yoilsho	162	11	different	different	JJ
cord-006229-7yoilsho	162	12	CXCR4	cxcr4	NN
cord-006229-7yoilsho	162	13	ligands	ligand	NNS
cord-006229-7yoilsho	162	14	in	in	IN
cord-006229-7yoilsho	162	15	acute	acute	NN
cord-006229-7yoilsho	162	16	as	as	RB
cord-006229-7yoilsho	162	17	well	well	RB
cord-006229-7yoilsho	162	18	as	as	IN
cord-006229-7yoilsho	162	19	chronic	chronic	JJ
cord-006229-7yoilsho	162	20	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	162	21	diseases	disease	NNS
cord-006229-7yoilsho	162	22	are	be	VBP
cord-006229-7yoilsho	162	23	still	still	RB
cord-006229-7yoilsho	162	24	contradictious	contradictious	JJ
cord-006229-7yoilsho	162	25	.	.	.
cord-006229-7yoilsho	163	1	Therefore	therefore	RB
cord-006229-7yoilsho	163	2	,	,	,
cord-006229-7yoilsho	163	3	we	-PRON-	PRP
cord-006229-7yoilsho	163	4	aimed	aim	VBD
cord-006229-7yoilsho	163	5	to	to	TO
cord-006229-7yoilsho	163	6	characterize	characterize	VB
cord-006229-7yoilsho	163	7	the	the	DT
cord-006229-7yoilsho	163	8	systemic	systemic	JJ
cord-006229-7yoilsho	163	9	effects	effect	NNS
cord-006229-7yoilsho	163	10	of	of	IN
cord-006229-7yoilsho	163	11	CXCR4	cxcr4	NN
cord-006229-7yoilsho	163	12	activation	activation	NN
cord-006229-7yoilsho	163	13	in	in	IN
cord-006229-7yoilsho	163	14	severe	severe	JJ
cord-006229-7yoilsho	163	15	systemic	systemic	JJ
cord-006229-7yoilsho	163	16	inflammation	inflammation	NN
cord-006229-7yoilsho	163	17	and	and	CC
cord-006229-7yoilsho	163	18	to	to	TO
cord-006229-7yoilsho	163	19	evaluate	evaluate	VB
cord-006229-7yoilsho	163	20	its	-PRON-	PRP$
cord-006229-7yoilsho	163	21	impact	impact	NN
cord-006229-7yoilsho	163	22	on	on	IN
cord-006229-7yoilsho	163	23	endotoxin	endotoxin	NN
cord-006229-7yoilsho	163	24	induced	induce	VBN
cord-006229-7yoilsho	163	25	organ	organ	NN
cord-006229-7yoilsho	163	26	damages	damage	NNS
cord-006229-7yoilsho	163	27	by	by	IN
cord-006229-7yoilsho	163	28	applying	apply	VBG
cord-006229-7yoilsho	163	29	a	a	DT
cord-006229-7yoilsho	163	30	sublethal	sublethal	JJ
cord-006229-7yoilsho	163	31	LPS	lp	NNS
cord-006229-7yoilsho	163	32	dose	dose	NN
cord-006229-7yoilsho	163	33	(	(	-LRB-
cord-006229-7yoilsho	163	34	5	5	CD
cord-006229-7yoilsho	163	35	mg	mg	NN
cord-006229-7yoilsho	163	36	/	/	SYM
cord-006229-7yoilsho	163	37	body	body	NN
cord-006229-7yoilsho	163	38	weight	weight	NN
cord-006229-7yoilsho	163	39	)	)	-RRB-
cord-006229-7yoilsho	163	40	in	in	IN
cord-006229-7yoilsho	163	41	mice	mouse	NNS
cord-006229-7yoilsho	163	42	.	.	.
cord-006229-7yoilsho	164	1	The	the	DT
cord-006229-7yoilsho	164	2	plasma	plasma	NN
cord-006229-7yoilsho	164	3	stable	stable	JJ
cord-006229-7yoilsho	164	4	CXCL12	CXCL12	NNP
cord-006229-7yoilsho	164	5	analog	analog	JJ
cord-006229-7yoilsho	164	6	CTCE-0214D	CTCE-0214D	NNPS
cord-006229-7yoilsho	164	7	was	be	VBD
cord-006229-7yoilsho	164	8	synthesized	synthesize	VBN
cord-006229-7yoilsho	164	9	and	and	CC
cord-006229-7yoilsho	164	10	administered	administer	VBN
cord-006229-7yoilsho	164	11	subcutaneously	subcutaneously	RB
cord-006229-7yoilsho	164	12	shortly	shortly	RB
cord-006229-7yoilsho	164	13	before	before	IN
cord-006229-7yoilsho	164	14	LPS	LPS	NNP
cord-006229-7yoilsho	164	15	treatment	treatment	NN
cord-006229-7yoilsho	164	16	to	to	TO
cord-006229-7yoilsho	164	17	ensure	ensure	VB
cord-006229-7yoilsho	164	18	a	a	DT
cord-006229-7yoilsho	164	19	delayed	delay	VBN
cord-006229-7yoilsho	164	20	release	release	NN
cord-006229-7yoilsho	164	21	and	and	CC
cord-006229-7yoilsho	164	22	thereby	thereby	RB
cord-006229-7yoilsho	164	23	a	a	DT
cord-006229-7yoilsho	164	24	prolonged	prolonged	JJ
cord-006229-7yoilsho	164	25	effect	effect	NN
cord-006229-7yoilsho	164	26	of	of	IN
cord-006229-7yoilsho	164	27	the	the	DT
cord-006229-7yoilsho	164	28	drug	drug	NN
cord-006229-7yoilsho	164	29	.	.	.
cord-006229-7yoilsho	165	1	24	24	CD
cord-006229-7yoilsho	165	2	hours	hour	NNS
cord-006229-7yoilsho	165	3	following	follow	VBG
cord-006229-7yoilsho	165	4	LPS	LPS	NNP
cord-006229-7yoilsho	165	5	administration	administration	NN
cord-006229-7yoilsho	165	6	,	,	,
cord-006229-7yoilsho	165	7	mice	mouse	NNS
cord-006229-7yoilsho	165	8	were	be	VBD
cord-006229-7yoilsho	165	9	sacrificed	sacrifice	VBN
cord-006229-7yoilsho	165	10	and	and	CC
cord-006229-7yoilsho	165	11	blood	blood	NN
cord-006229-7yoilsho	165	12	was	be	VBD
cord-006229-7yoilsho	165	13	obtained	obtain	VBN
cord-006229-7yoilsho	165	14	for	for	IN
cord-006229-7yoilsho	165	15	TNF	TNF	NNP
cord-006229-7yoilsho	165	16	alpha	alpha	NN
cord-006229-7yoilsho	165	17	,	,	,
cord-006229-7yoilsho	165	18	IFN	IFN	NNP
cord-006229-7yoilsho	165	19	gamma	gamma	NN
cord-006229-7yoilsho	165	20	and	and	CC
cord-006229-7yoilsho	165	21	blood	blood	NN
cord-006229-7yoilsho	165	22	glucose	glucose	NN
cord-006229-7yoilsho	165	23	evaluation	evaluation	NN
cord-006229-7yoilsho	165	24	.	.	.
cord-006229-7yoilsho	166	1	Additionally	additionally	RB
cord-006229-7yoilsho	166	2	,	,	,
cord-006229-7yoilsho	166	3	histopathological	histopathological	JJ
cord-006229-7yoilsho	166	4	changes	change	NNS
cord-006229-7yoilsho	166	5	and	and	CC
cord-006229-7yoilsho	166	6	oxidative	oxidative	JJ
cord-006229-7yoilsho	166	7	stress	stress	NN
cord-006229-7yoilsho	166	8	in	in	IN
cord-006229-7yoilsho	166	9	the	the	DT
cord-006229-7yoilsho	166	10	liver	liver	NN
cord-006229-7yoilsho	166	11	and	and	CC
cord-006229-7yoilsho	166	12	spleen	spleen	NNS
cord-006229-7yoilsho	166	13	were	be	VBD
cord-006229-7yoilsho	166	14	assessed	assess	VBN
cord-006229-7yoilsho	166	15	and	and	CC
cord-006229-7yoilsho	166	16	liver	liver	NN
cord-006229-7yoilsho	166	17	biotransformation	biotransformation	NN
cord-006229-7yoilsho	166	18	capacity	capacity	NN
cord-006229-7yoilsho	166	19	was	be	VBD
cord-006229-7yoilsho	166	20	determined	determine	VBN
cord-006229-7yoilsho	166	21	.	.	.
cord-006229-7yoilsho	167	1	Finally	finally	RB
cord-006229-7yoilsho	167	2	,	,	,
cord-006229-7yoilsho	167	3	CXCR4	CXCR4	NNP
cord-006229-7yoilsho	167	4	,	,	,
cord-006229-7yoilsho	167	5	CXCL12	CXCL12	NNP
cord-006229-7yoilsho	167	6	and	and	CC
cord-006229-7yoilsho	167	7	TLR4	TLR4	NNP
cord-006229-7yoilsho	167	8	expression	expression	NN
cord-006229-7yoilsho	167	9	patterns	pattern	NNS
cord-006229-7yoilsho	167	10	in	in	IN
cord-006229-7yoilsho	167	11	liver	liver	NN
cord-006229-7yoilsho	167	12	,	,	,
cord-006229-7yoilsho	167	13	spleen	spleen	NN
cord-006229-7yoilsho	167	14	and	and	CC
cord-006229-7yoilsho	167	15	thymus	thymus	NN
cord-006229-7yoilsho	167	16	tissue	tissue	NN
cord-006229-7yoilsho	167	17	as	as	RB
cord-006229-7yoilsho	167	18	well	well	RB
cord-006229-7yoilsho	167	19	as	as	IN
cord-006229-7yoilsho	167	20	the	the	DT
cord-006229-7yoilsho	167	21	presence	presence	NN
cord-006229-7yoilsho	167	22	of	of	IN
cord-006229-7yoilsho	167	23	different	different	JJ
cord-006229-7yoilsho	167	24	markers	marker	NNS
cord-006229-7yoilsho	167	25	for	for	IN
cord-006229-7yoilsho	167	26	oxidative	oxidative	JJ
cord-006229-7yoilsho	167	27	stress	stress	NN
cord-006229-7yoilsho	167	28	and	and	CC
cord-006229-7yoilsho	167	29	apoptosis	apoptosis	NN
cord-006229-7yoilsho	167	30	were	be	VBD
cord-006229-7yoilsho	167	31	evaluated	evaluate	VBN
cord-006229-7yoilsho	167	32	by	by	IN
cord-006229-7yoilsho	167	33	means	mean	NNS
cord-006229-7yoilsho	167	34	of	of	IN
cord-006229-7yoilsho	167	35	immunohistochemistry	immunohistochemistry	NN
cord-006229-7yoilsho	167	36	.	.	.
cord-006229-7yoilsho	168	1	CTCE-0214D	CTCE-0214D	NNP
cord-006229-7yoilsho	168	2	improved	improve	VBD
cord-006229-7yoilsho	168	3	the	the	DT
cord-006229-7yoilsho	168	4	health	health	NN
cord-006229-7yoilsho	168	5	status	status	NN
cord-006229-7yoilsho	168	6	and	and	CC
cord-006229-7yoilsho	168	7	distinctly	distinctly	RB
cord-006229-7yoilsho	168	8	reduced	reduce	VBD
cord-006229-7yoilsho	168	9	the	the	DT
cord-006229-7yoilsho	168	10	LPS	lp	NNS
cord-006229-7yoilsho	168	11	mediated	mediate	VBD
cord-006229-7yoilsho	168	12	effects	effect	NNS
cord-006229-7yoilsho	168	13	on	on	IN
cord-006229-7yoilsho	168	14	TNF	TNF	NNP
cord-006229-7yoilsho	168	15	alpha	alpha	NN
cord-006229-7yoilsho	168	16	,	,	,
cord-006229-7yoilsho	168	17	IFN	IFN	NNP
cord-006229-7yoilsho	168	18	gamma	gamma	NN
cord-006229-7yoilsho	168	19	and	and	CC
cord-006229-7yoilsho	168	20	blood	blood	NN
cord-006229-7yoilsho	168	21	glucose	glucose	NN
cord-006229-7yoilsho	168	22	levels	level	NNS
cord-006229-7yoilsho	168	23	by	by	IN
cord-006229-7yoilsho	168	24	approximately	approximately	RB
cord-006229-7yoilsho	168	25	35	35	CD
cord-006229-7yoilsho	168	26	%	%	NN
cord-006229-7yoilsho	168	27	,	,	,
cord-006229-7yoilsho	168	28	50	50	CD
cord-006229-7yoilsho	168	29	%	%	NN
cord-006229-7yoilsho	168	30	or	or	CC
cord-006229-7yoilsho	168	31	70	70	CD
cord-006229-7yoilsho	168	32	%	%	NN
cord-006229-7yoilsho	168	33	,	,	,
cord-006229-7yoilsho	168	34	respectively	respectively	RB
cord-006229-7yoilsho	168	35	.	.	.
cord-006229-7yoilsho	169	1	It	-PRON-	PRP
cord-006229-7yoilsho	169	2	attenuated	attenuate	VBD
cord-006229-7yoilsho	169	3	oxidative	oxidative	JJ
cord-006229-7yoilsho	169	4	stress	stress	NN
cord-006229-7yoilsho	169	5	in	in	IN
cord-006229-7yoilsho	169	6	the	the	DT
cord-006229-7yoilsho	169	7	liver	liver	NN
cord-006229-7yoilsho	169	8	and	and	CC
cord-006229-7yoilsho	169	9	spleen	spleen	NN
cord-006229-7yoilsho	169	10	tissue	tissue	NN
cord-006229-7yoilsho	169	11	and	and	CC
cord-006229-7yoilsho	169	12	enhanced	enhanced	JJ
cord-006229-7yoilsho	169	13	liver	liver	NN
cord-006229-7yoilsho	169	14	biotransformation	biotransformation	NN
cord-006229-7yoilsho	169	15	capacity	capacity	NN
cord-006229-7yoilsho	169	16	unambiguously	unambiguously	RB
cord-006229-7yoilsho	169	17	.	.	.
cord-006229-7yoilsho	170	1	CTCE-0214D	CTCE-0214D	NNP
cord-006229-7yoilsho	170	2	diminished	diminish	VBD
cord-006229-7yoilsho	170	3	the	the	DT
cord-006229-7yoilsho	170	4	LPS	LPS	NNP
cord-006229-7yoilsho	170	5	induced	induce	VBN
cord-006229-7yoilsho	170	6	expression	expression	NN
cord-006229-7yoilsho	170	7	of	of	IN
cord-006229-7yoilsho	170	8	CXCR4	CXCR4	NNS
cord-006229-7yoilsho	170	9	,	,	,
cord-006229-7yoilsho	170	10	CXCL12	CXCL12	NNP
cord-006229-7yoilsho	170	11	,	,	,
cord-006229-7yoilsho	170	12	TLR4	TLR4	NNP
cord-006229-7yoilsho	170	13	,	,	,
cord-006229-7yoilsho	170	14	NF	NF	NNP
cord-006229-7yoilsho	170	15	-	-	HYPH
cord-006229-7yoilsho	170	16	κB	κB	NNP
cord-006229-7yoilsho	170	17	,	,	,
cord-006229-7yoilsho	170	18	cleaved	cleave	VBD
cord-006229-7yoilsho	170	19	caspase-3	caspase-3	NNP
cord-006229-7yoilsho	170	20	and	and	CC
cord-006229-7yoilsho	170	21	gp91	gp91	NNP
cord-006229-7yoilsho	170	22	phox	phox	NNP
cord-006229-7yoilsho	170	23	,	,	,
cord-006229-7yoilsho	170	24	whereas	whereas	IN
cord-006229-7yoilsho	170	25	heme	heme	NN
cord-006229-7yoilsho	170	26	oxygenase	oxygenase	NN
cord-006229-7yoilsho	170	27	1	1	CD
cord-006229-7yoilsho	170	28	expression	expression	NN
cord-006229-7yoilsho	170	29	and	and	CC
cord-006229-7yoilsho	170	30	activity	activity	NN
cord-006229-7yoilsho	170	31	were	be	VBD
cord-006229-7yoilsho	170	32	induced	induce	VBN
cord-006229-7yoilsho	170	33	above	above	IN
cord-006229-7yoilsho	170	34	average	average	JJ
cord-006229-7yoilsho	170	35	.	.	.
cord-006229-7yoilsho	171	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	171	2	,	,	,
cord-006229-7yoilsho	171	3	TUNEL	TUNEL	NNP
cord-006229-7yoilsho	171	4	staining	staining	NN
cord-006229-7yoilsho	171	5	revealed	reveal	VBD
cord-006229-7yoilsho	171	6	anti	anti	JJ
cord-006229-7yoilsho	171	7	-	-	JJ
cord-006229-7yoilsho	171	8	apoptotic	apoptotic	JJ
cord-006229-7yoilsho	171	9	effects	effect	NNS
cord-006229-7yoilsho	171	10	of	of	IN
cord-006229-7yoilsho	171	11	CTCE-0214D	CTCE-0214D	NNS
cord-006229-7yoilsho	171	12	in	in	IN
cord-006229-7yoilsho	171	13	all	all	DT
cord-006229-7yoilsho	171	14	organs	organ	NNS
cord-006229-7yoilsho	171	15	.	.	.
cord-006229-7yoilsho	172	1	The	the	DT
cord-006229-7yoilsho	172	2	CXCR4	cxcr4	NN
cord-006229-7yoilsho	172	3	is	be	VBZ
cord-006229-7yoilsho	172	4	undoubtedly	undoubtedly	RB
cord-006229-7yoilsho	172	5	involved	involve	VBN
cord-006229-7yoilsho	172	6	in	in	IN
cord-006229-7yoilsho	172	7	inflammation	inflammation	NN
cord-006229-7yoilsho	172	8	.	.	.
cord-006229-7yoilsho	173	1	Its	-PRON-	PRP$
cord-006229-7yoilsho	173	2	activation	activation	NN
cord-006229-7yoilsho	173	3	was	be	VBD
cord-006229-7yoilsho	173	4	accompanied	accompany	VBN
cord-006229-7yoilsho	173	5	by	by	IN
cord-006229-7yoilsho	173	6	anti	anti	JJ
cord-006229-7yoilsho	173	7	-	-	JJ
cord-006229-7yoilsho	173	8	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	173	9	,	,	,
cord-006229-7yoilsho	173	10	anti	anti	JJ
cord-006229-7yoilsho	173	11	-	-	JJ
cord-006229-7yoilsho	173	12	oxidative	oxidative	JJ
cord-006229-7yoilsho	173	13	and	and	CC
cord-006229-7yoilsho	173	14	cytoprotective	cytoprotective	JJ
cord-006229-7yoilsho	173	15	effects	effect	NNS
cord-006229-7yoilsho	173	16	as	as	IN
cord-006229-7yoilsho	173	17	CTCE-0214D	CTCE-0214D	NNPS
cord-006229-7yoilsho	173	18	attenuated	attenuate	VBD
cord-006229-7yoilsho	173	19	TLR4	TLR4	NNP
cord-006229-7yoilsho	173	20	signaling	signaling	NN
cord-006229-7yoilsho	173	21	,	,	,
cord-006229-7yoilsho	173	22	induced	induce	VBN
cord-006229-7yoilsho	173	23	heme	heme	NN
cord-006229-7yoilsho	173	24	oxygenase	oxygenase	NN
cord-006229-7yoilsho	173	25	1	1	CD
cord-006229-7yoilsho	173	26	activity	activity	NN
cord-006229-7yoilsho	173	27	and	and	CC
cord-006229-7yoilsho	173	28	mitigated	mitigate	VBD
cord-006229-7yoilsho	173	29	apoptosis	apoptosis	NN
cord-006229-7yoilsho	173	30	.	.	.
cord-006229-7yoilsho	174	1	Thus	thus	RB
cord-006229-7yoilsho	174	2	,	,	,
cord-006229-7yoilsho	174	3	the	the	DT
cord-006229-7yoilsho	174	4	administration	administration	NN
cord-006229-7yoilsho	174	5	of	of	IN
cord-006229-7yoilsho	174	6	CXCL12	CXCL12	NNP
cord-006229-7yoilsho	174	7	analogs	analog	NNS
cord-006229-7yoilsho	174	8	seems	seem	VBZ
cord-006229-7yoilsho	174	9	to	to	TO
cord-006229-7yoilsho	174	10	be	be	VB
cord-006229-7yoilsho	174	11	a	a	DT
cord-006229-7yoilsho	174	12	promising	promising	JJ
cord-006229-7yoilsho	174	13	treatment	treatment	NN
cord-006229-7yoilsho	174	14	option	option	NN
cord-006229-7yoilsho	174	15	to	to	TO
cord-006229-7yoilsho	174	16	control	control	VB
cord-006229-7yoilsho	174	17	acute	acute	JJ
cord-006229-7yoilsho	174	18	systemic	systemic	JJ
cord-006229-7yoilsho	174	19	inflammation	inflammation	NN
cord-006229-7yoilsho	174	20	,	,	,
cord-006229-7yoilsho	174	21	especially	especially	RB
cord-006229-7yoilsho	174	22	when	when	WRB
cord-006229-7yoilsho	174	23	accompanied	accompany	VBN
cord-006229-7yoilsho	174	24	by	by	IN
cord-006229-7yoilsho	174	25	a	a	DT
cord-006229-7yoilsho	174	26	hepatic	hepatic	JJ
cord-006229-7yoilsho	174	27	dysfunction	dysfunction	NN
cord-006229-7yoilsho	174	28	and	and	CC
cord-006229-7yoilsho	174	29	an	an	DT
cord-006229-7yoilsho	174	30	excessive	excessive	JJ
cord-006229-7yoilsho	174	31	production	production	NN
cord-006229-7yoilsho	174	32	of	of	IN
cord-006229-7yoilsho	174	33	free	free	JJ
cord-006229-7yoilsho	174	34	radicals	radical	NNS
cord-006229-7yoilsho	174	35	.	.	.
cord-006229-7yoilsho	175	1	The	the	DT
cord-006229-7yoilsho	175	2	neurodegenerative	neurodegenerative	JJ
cord-006229-7yoilsho	175	3	disease	disease	NN
cord-006229-7yoilsho	175	4	Friedreich	Friedreich	NNP
cord-006229-7yoilsho	175	5	ataxia	ataxia	NN
cord-006229-7yoilsho	175	6	(	(	-LRB-
cord-006229-7yoilsho	175	7	FRDA	FRDA	NNP
cord-006229-7yoilsho	175	8	)	)	-RRB-
cord-006229-7yoilsho	175	9	is	be	VBZ
cord-006229-7yoilsho	175	10	caused	cause	VBN
cord-006229-7yoilsho	175	11	by	by	IN
cord-006229-7yoilsho	175	12	a	a	DT
cord-006229-7yoilsho	175	13	GAA	GAA	NNP
cord-006229-7yoilsho	175	14	triplet	triplet	NN
cord-006229-7yoilsho	175	15	repeat	repeat	VB
cord-006229-7yoilsho	175	16	expansion	expansion	NN
cord-006229-7yoilsho	175	17	in	in	IN
cord-006229-7yoilsho	175	18	the	the	DT
cord-006229-7yoilsho	175	19	first	first	JJ
cord-006229-7yoilsho	175	20	intron	intron	NN
cord-006229-7yoilsho	175	21	of	of	IN
cord-006229-7yoilsho	175	22	the	the	DT
cord-006229-7yoilsho	175	23	frataxin	frataxin	NNP
cord-006229-7yoilsho	175	24	gene	gene	NN
cord-006229-7yoilsho	175	25	,	,	,
cord-006229-7yoilsho	175	26	which	which	WDT
cord-006229-7yoilsho	175	27	results	result	VBZ
cord-006229-7yoilsho	175	28	in	in	IN
cord-006229-7yoilsho	175	29	a	a	DT
cord-006229-7yoilsho	175	30	reduction	reduction	NN
cord-006229-7yoilsho	175	31	of	of	IN
cord-006229-7yoilsho	175	32	the	the	DT
cord-006229-7yoilsho	175	33	corresponding	corresponding	JJ
cord-006229-7yoilsho	175	34	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	175	35	protein	protein	NN
cord-006229-7yoilsho	175	36	.	.	.
cord-006229-7yoilsho	176	1	Despite	despite	IN
cord-006229-7yoilsho	176	2	several	several	JJ
cord-006229-7yoilsho	176	3	cellular	cellular	JJ
cord-006229-7yoilsho	176	4	and	and	CC
cord-006229-7yoilsho	176	5	animal	animal	NN
cord-006229-7yoilsho	176	6	models	model	NNS
cord-006229-7yoilsho	176	7	the	the	DT
cord-006229-7yoilsho	176	8	exact	exact	JJ
cord-006229-7yoilsho	176	9	function	function	NN
cord-006229-7yoilsho	176	10	of	of	IN
cord-006229-7yoilsho	176	11	frataxin	frataxin	NN
cord-006229-7yoilsho	176	12	is	be	VBZ
cord-006229-7yoilsho	176	13	still	still	RB
cord-006229-7yoilsho	176	14	a	a	DT
cord-006229-7yoilsho	176	15	matter	matter	NN
cord-006229-7yoilsho	176	16	of	of	IN
cord-006229-7yoilsho	176	17	debate	debate	NN
cord-006229-7yoilsho	176	18	,	,	,
cord-006229-7yoilsho	176	19	but	but	CC
cord-006229-7yoilsho	176	20	the	the	DT
cord-006229-7yoilsho	176	21	role	role	NN
cord-006229-7yoilsho	176	22	of	of	IN
cord-006229-7yoilsho	176	23	frataxin	frataxin	NN
cord-006229-7yoilsho	176	24	in	in	IN
cord-006229-7yoilsho	176	25	iron	iron	NN
cord-006229-7yoilsho	176	26	sulfur	sulfur	NN
cord-006229-7yoilsho	176	27	cluster	cluster	NN
cord-006229-7yoilsho	176	28	biosynthesis	biosynthesis	NN
cord-006229-7yoilsho	176	29	is	be	VBZ
cord-006229-7yoilsho	176	30	generally	generally	RB
cord-006229-7yoilsho	176	31	accepted	accept	VBN
cord-006229-7yoilsho	176	32	.	.	.
cord-006229-7yoilsho	177	1	However	however	RB
cord-006229-7yoilsho	177	2	,	,	,
cord-006229-7yoilsho	177	3	we	-PRON-	PRP
cord-006229-7yoilsho	177	4	still	still	RB
cord-006229-7yoilsho	177	5	do	do	VBP
cord-006229-7yoilsho	177	6	n't	not	RB
cord-006229-7yoilsho	177	7	know	know	VB
cord-006229-7yoilsho	177	8	which	which	WDT
cord-006229-7yoilsho	177	9	primary	primary	JJ
cord-006229-7yoilsho	177	10	metabolic	metabolic	JJ
cord-006229-7yoilsho	177	11	events	event	NNS
cord-006229-7yoilsho	177	12	are	be	VBP
cord-006229-7yoilsho	177	13	caused	cause	VBN
cord-006229-7yoilsho	177	14	by	by	IN
cord-006229-7yoilsho	177	15	a	a	DT
cord-006229-7yoilsho	177	16	frataxin	frataxin	JJ
cord-006229-7yoilsho	177	17	deficit	deficit	NN
cord-006229-7yoilsho	177	18	and	and	CC
cord-006229-7yoilsho	177	19	until	until	IN
cord-006229-7yoilsho	177	20	now	now	RB
cord-006229-7yoilsho	177	21	,	,	,
cord-006229-7yoilsho	177	22	there	there	EX
cord-006229-7yoilsho	177	23	is	be	VBZ
cord-006229-7yoilsho	177	24	no	no	DT
cord-006229-7yoilsho	177	25	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	177	26	option	option	NN
cord-006229-7yoilsho	177	27	available	available	JJ
cord-006229-7yoilsho	177	28	.	.	.
cord-006229-7yoilsho	178	1	We	-PRON-	PRP
cord-006229-7yoilsho	178	2	developed	develop	VBD
cord-006229-7yoilsho	178	3	a	a	DT
cord-006229-7yoilsho	178	4	new	new	JJ
cord-006229-7yoilsho	178	5	cellular	cellular	JJ
cord-006229-7yoilsho	178	6	model	model	NN
cord-006229-7yoilsho	178	7	for	for	IN
cord-006229-7yoilsho	178	8	FRDA	FRDA	NNP
cord-006229-7yoilsho	178	9	by	by	IN
cord-006229-7yoilsho	178	10	using	use	VBG
cord-006229-7yoilsho	178	11	the	the	DT
cord-006229-7yoilsho	178	12	cre	cre	NNP
cord-006229-7yoilsho	178	13	/	/	SYM
cord-006229-7yoilsho	178	14	loxP	loxP	NNP
cord-006229-7yoilsho	178	15	recombination	recombination	NN
cord-006229-7yoilsho	178	16	system	system	NN
cord-006229-7yoilsho	178	17	in	in	IN
cord-006229-7yoilsho	178	18	mouse	mouse	NN
cord-006229-7yoilsho	178	19	embryonic	embryonic	JJ
cord-006229-7yoilsho	178	20	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	178	21	(	(	-LRB-
cord-006229-7yoilsho	178	22	MEF	MEF	NNP
cord-006229-7yoilsho	178	23	)	)	-RRB-
cord-006229-7yoilsho	178	24	.	.	.
cord-006229-7yoilsho	179	1	C57BL/6J	C57BL/6J	NNP
cord-006229-7yoilsho	179	2	mouse	mouse	NN
cord-006229-7yoilsho	179	3	strains	strain	NNS
cord-006229-7yoilsho	179	4	with	with	IN
cord-006229-7yoilsho	179	5	a	a	DT
cord-006229-7yoilsho	179	6	loxP	loxP	NNP
cord-006229-7yoilsho	179	7	flanked	flank	VBN
cord-006229-7yoilsho	179	8	exon	exon	NN
cord-006229-7yoilsho	179	9	4	4	CD
cord-006229-7yoilsho	179	10	of	of	IN
cord-006229-7yoilsho	179	11	the	the	DT
cord-006229-7yoilsho	179	12	frataxin	frataxin	NN
cord-006229-7yoilsho	179	13	gene	gene	NN
cord-006229-7yoilsho	179	14	and	and	CC
cord-006229-7yoilsho	179	15	an	an	DT
cord-006229-7yoilsho	179	16	tamoxifen	tamoxifen	NN
cord-006229-7yoilsho	179	17	-	-	HYPH
cord-006229-7yoilsho	179	18	inducible	inducible	JJ
cord-006229-7yoilsho	179	19	cre	cre	JJ
cord-006229-7yoilsho	179	20	-	-	HYPH
cord-006229-7yoilsho	179	21	recombinase	recombinase	NNP
cord-006229-7yoilsho	179	22	(	(	-LRB-
cord-006229-7yoilsho	179	23	CreER	CreER	NNP
cord-006229-7yoilsho	179	24	T2	T2	NNP
cord-006229-7yoilsho	179	25	)	)	-RRB-
cord-006229-7yoilsho	179	26	were	be	VBD
cord-006229-7yoilsho	179	27	crossed	cross	VBN
cord-006229-7yoilsho	179	28	and	and	CC
cord-006229-7yoilsho	179	29	several	several	JJ
cord-006229-7yoilsho	179	30	MEF	MEF	NNP
cord-006229-7yoilsho	179	31	cell	cell	NN
cord-006229-7yoilsho	179	32	lines	line	NNS
cord-006229-7yoilsho	179	33	isolated	isolate	VBN
cord-006229-7yoilsho	179	34	.	.	.
cord-006229-7yoilsho	180	1	After	after	IN
cord-006229-7yoilsho	180	2	selection	selection	NN
cord-006229-7yoilsho	180	3	by	by	IN
cord-006229-7yoilsho	180	4	genotype	genotype	NN
cord-006229-7yoilsho	180	5	and	and	CC
cord-006229-7yoilsho	180	6	growth	growth	NN
cord-006229-7yoilsho	180	7	manner	manner	NN
cord-006229-7yoilsho	181	1	the	the	DT
cord-006229-7yoilsho	181	2	FX	FX	NNP
cord-006229-7yoilsho	181	3	-	-	HYPH
cord-006229-7yoilsho	181	4	MEF	MEF	NNP
cord-006229-7yoilsho	181	5	2	2	CD
cord-006229-7yoilsho	181	6	-	-	SYM
cord-006229-7yoilsho	181	7	1	1	CD
cord-006229-7yoilsho	181	8	(	(	-LRB-
cord-006229-7yoilsho	181	9	Fxn	Fxn	NNP
cord-006229-7yoilsho	181	10	-/-	-/-	NNP
cord-006229-7yoilsho	181	11	)	)	-RRB-
cord-006229-7yoilsho	181	12	and	and	CC
cord-006229-7yoilsho	181	13	FX	FX	NNP
cord-006229-7yoilsho	181	14	-	-	HYPH
cord-006229-7yoilsho	181	15	MEF	MEF	NNP
cord-006229-7yoilsho	181	16	2	2	CD
cord-006229-7yoilsho	181	17	-	-	SYM
cord-006229-7yoilsho	181	18	8	8	CD
cord-006229-7yoilsho	181	19	(	(	-LRB-
cord-006229-7yoilsho	181	20	Fxn	Fxn	NNP
cord-006229-7yoilsho	181	21	+	+	CC
cord-006229-7yoilsho	181	22	/-	/-	.
cord-006229-7yoilsho	181	23	)	)	-RRB-
cord-006229-7yoilsho	182	1	cell	cell	NN
cord-006229-7yoilsho	182	2	lines	line	NNS
cord-006229-7yoilsho	182	3	were	be	VBD
cord-006229-7yoilsho	182	4	finally	finally	RB
cord-006229-7yoilsho	182	5	choosed	choose	VBN
cord-006229-7yoilsho	182	6	.	.	.
cord-006229-7yoilsho	183	1	The	the	DT
cord-006229-7yoilsho	183	2	generation	generation	NN
cord-006229-7yoilsho	183	3	of	of	IN
cord-006229-7yoilsho	183	4	the	the	DT
cord-006229-7yoilsho	183	5	homozygous	homozygous	JJ
cord-006229-7yoilsho	183	6	or	or	CC
cord-006229-7yoilsho	183	7	heterozygous	heterozygous	JJ
cord-006229-7yoilsho	183	8	frataxin	frataxin	NN
cord-006229-7yoilsho	183	9	knockout	knockout	NN
cord-006229-7yoilsho	183	10	was	be	VBD
cord-006229-7yoilsho	183	11	successfully	successfully	RB
cord-006229-7yoilsho	183	12	tested	test	VBN
cord-006229-7yoilsho	183	13	on	on	IN
cord-006229-7yoilsho	183	14	RNA	RNA	NNP
cord-006229-7yoilsho	183	15	and	and	CC
cord-006229-7yoilsho	183	16	protein	protein	NN
cord-006229-7yoilsho	183	17	level	level	NN
cord-006229-7yoilsho	183	18	.	.	.
cord-006229-7yoilsho	184	1	Long	long	JJ
cord-006229-7yoilsho	184	2	maintenance	maintenance	NN
cord-006229-7yoilsho	184	3	of	of	IN
cord-006229-7yoilsho	184	4	the	the	DT
cord-006229-7yoilsho	184	5	frataxin	frataxin	NN
cord-006229-7yoilsho	184	6	depleted	deplete	VBN
cord-006229-7yoilsho	184	7	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	184	8	revealed	reveal	VBD
cord-006229-7yoilsho	184	9	a	a	DT
cord-006229-7yoilsho	184	10	strong	strong	JJ
cord-006229-7yoilsho	184	11	growth	growth	NN
cord-006229-7yoilsho	184	12	inhibition	inhibition	NN
cord-006229-7yoilsho	184	13	consistent	consistent	JJ
cord-006229-7yoilsho	184	14	to	to	IN
cord-006229-7yoilsho	184	15	earlier	early	JJR
cord-006229-7yoilsho	184	16	observations	observation	NNS
cord-006229-7yoilsho	184	17	in	in	IN
cord-006229-7yoilsho	184	18	other	other	JJ
cord-006229-7yoilsho	184	19	cell	cell	NN
cord-006229-7yoilsho	184	20	systems	system	NNS
cord-006229-7yoilsho	184	21	.	.	.
cord-006229-7yoilsho	185	1	Therefore	therefore	RB
cord-006229-7yoilsho	185	2	,	,	,
cord-006229-7yoilsho	185	3	we	-PRON-	PRP
cord-006229-7yoilsho	185	4	established	establish	VBD
cord-006229-7yoilsho	185	5	a	a	DT
cord-006229-7yoilsho	185	6	pattern	pattern	NN
cord-006229-7yoilsho	185	7	of	of	IN
cord-006229-7yoilsho	185	8	treatment	treatment	NN
cord-006229-7yoilsho	185	9	over	over	IN
cord-006229-7yoilsho	185	10	12	12	CD
cord-006229-7yoilsho	185	11	days	day	NNS
cord-006229-7yoilsho	185	12	,	,	,
cord-006229-7yoilsho	185	13	with	with	IN
cord-006229-7yoilsho	185	14	medium	medium	NN
cord-006229-7yoilsho	185	15	and	and	CC
cord-006229-7yoilsho	185	16	substance	substance	NN
cord-006229-7yoilsho	185	17	changes	change	NNS
cord-006229-7yoilsho	185	18	at	at	IN
cord-006229-7yoilsho	185	19	day	day	NN
cord-006229-7yoilsho	185	20	4	4	CD
cord-006229-7yoilsho	185	21	and	and	CC
cord-006229-7yoilsho	185	22	8	8	CD
cord-006229-7yoilsho	185	23	,	,	,
cord-006229-7yoilsho	185	24	which	which	WDT
cord-006229-7yoilsho	185	25	allows	allow	VBZ
cord-006229-7yoilsho	185	26	us	-PRON-	PRP
cord-006229-7yoilsho	185	27	to	to	TO
cord-006229-7yoilsho	185	28	get	get	VB
cord-006229-7yoilsho	185	29	a	a	DT
cord-006229-7yoilsho	185	30	fully	fully	RB
cord-006229-7yoilsho	185	31	functional	functional	JJ
cord-006229-7yoilsho	185	32	knockout	knockout	NN
cord-006229-7yoilsho	185	33	and	and	CC
cord-006229-7yoilsho	185	34	overcome	overcome	VB
cord-006229-7yoilsho	185	35	the	the	DT
cord-006229-7yoilsho	185	36	growth	growth	NN
cord-006229-7yoilsho	185	37	inhibition	inhibition	NN
cord-006229-7yoilsho	185	38	problem	problem	NN
cord-006229-7yoilsho	185	39	.	.	.
cord-006229-7yoilsho	186	1	Endpoint	endpoint	NN
cord-006229-7yoilsho	186	2	measurements	measurement	NNS
cord-006229-7yoilsho	186	3	of	of	IN
cord-006229-7yoilsho	186	4	known	know	VBN
cord-006229-7yoilsho	186	5	metabolic	metabolic	JJ
cord-006229-7yoilsho	186	6	phenomena	phenomenon	NNS
cord-006229-7yoilsho	186	7	from	from	IN
cord-006229-7yoilsho	186	8	mammalian	mammalian	JJ
cord-006229-7yoilsho	186	9	and	and	CC
cord-006229-7yoilsho	186	10	non	non	JJ
cord-006229-7yoilsho	186	11	-	-	JJ
cord-006229-7yoilsho	186	12	mammalian	mammalian	JJ
cord-006229-7yoilsho	186	13	models	model	NNS
cord-006229-7yoilsho	186	14	were	be	VBD
cord-006229-7yoilsho	186	15	studied	study	VBN
cord-006229-7yoilsho	186	16	at	at	IN
cord-006229-7yoilsho	186	17	day	day	NN
cord-006229-7yoilsho	186	18	12	12	CD
cord-006229-7yoilsho	186	19	of	of	IN
cord-006229-7yoilsho	186	20	our	-PRON-	PRP$
cord-006229-7yoilsho	186	21	novel	novel	JJ
cord-006229-7yoilsho	186	22	cell	cell	NN
cord-006229-7yoilsho	186	23	system	system	NN
cord-006229-7yoilsho	186	24	.	.	.
cord-006229-7yoilsho	187	1	The	the	DT
cord-006229-7yoilsho	187	2	induced	induce	VBN
cord-006229-7yoilsho	187	3	total	total	JJ
cord-006229-7yoilsho	187	4	disruption	disruption	NN
cord-006229-7yoilsho	187	5	of	of	IN
cord-006229-7yoilsho	187	6	frataxin	frataxin	NN
cord-006229-7yoilsho	187	7	leads	lead	VBZ
cord-006229-7yoilsho	187	8	to	to	IN
cord-006229-7yoilsho	187	9	a	a	DT
cord-006229-7yoilsho	187	10	clearly	clearly	RB
cord-006229-7yoilsho	187	11	reduced	reduce	VBN
cord-006229-7yoilsho	187	12	aconitase	aconitase	NN
cord-006229-7yoilsho	187	13	activity	activity	NN
cord-006229-7yoilsho	187	14	,	,	,
cord-006229-7yoilsho	187	15	cell	cell	NN
cord-006229-7yoilsho	187	16	division	division	NN
cord-006229-7yoilsho	187	17	and	and	CC
cord-006229-7yoilsho	187	18	oxygen	oxygen	NN
cord-006229-7yoilsho	187	19	consumption	consumption	NN
cord-006229-7yoilsho	187	20	as	as	RB
cord-006229-7yoilsho	187	21	well	well	RB
cord-006229-7yoilsho	187	22	as	as	IN
cord-006229-7yoilsho	187	23	an	an	DT
cord-006229-7yoilsho	187	24	increase	increase	NN
cord-006229-7yoilsho	187	25	in	in	IN
cord-006229-7yoilsho	187	26	ROS	ROS	NNP
cord-006229-7yoilsho	187	27	production	production	NN
cord-006229-7yoilsho	187	28	.	.	.
cord-006229-7yoilsho	188	1	In	in	IN
cord-006229-7yoilsho	188	2	the	the	DT
cord-006229-7yoilsho	188	3	heterozygous	heterozygous	JJ
cord-006229-7yoilsho	188	4	knockout	knockout	NN
cord-006229-7yoilsho	188	5	with	with	IN
cord-006229-7yoilsho	188	6	residual	residual	JJ
cord-006229-7yoilsho	188	7	frataxin	frataxin	NN
cord-006229-7yoilsho	188	8	activity	activity	NN
cord-006229-7yoilsho	188	9	no	no	DT
cord-006229-7yoilsho	188	10	such	such	JJ
cord-006229-7yoilsho	188	11	changes	change	NNS
cord-006229-7yoilsho	188	12	were	be	VBD
cord-006229-7yoilsho	188	13	observed	observe	VBN
cord-006229-7yoilsho	188	14	.	.	.
cord-006229-7yoilsho	189	1	In	in	IN
cord-006229-7yoilsho	189	2	addition	addition	NN
cord-006229-7yoilsho	189	3	,	,	,
cord-006229-7yoilsho	189	4	our	-PRON-	PRP$
cord-006229-7yoilsho	189	5	pattern	pattern	NN
cord-006229-7yoilsho	189	6	of	of	IN
cord-006229-7yoilsho	189	7	treatment	treatment	NN
cord-006229-7yoilsho	189	8	enables	enable	VBZ
cord-006229-7yoilsho	189	9	us	-PRON-	PRP
cord-006229-7yoilsho	189	10	to	to	TO
cord-006229-7yoilsho	189	11	monitor	monitor	VB
cord-006229-7yoilsho	189	12	the	the	DT
cord-006229-7yoilsho	189	13	full	full	JJ
cord-006229-7yoilsho	189	14	and	and	CC
cord-006229-7yoilsho	189	15	partial	partial	JJ
cord-006229-7yoilsho	189	16	frataxin	frataxin	NN
cord-006229-7yoilsho	189	17	knockout	knockout	NN
cord-006229-7yoilsho	189	18	in	in	IN
cord-006229-7yoilsho	189	19	the	the	DT
cord-006229-7yoilsho	189	20	course	course	NN
cord-006229-7yoilsho	189	21	of	of	IN
cord-006229-7yoilsho	189	22	time	time	NN
cord-006229-7yoilsho	189	23	,	,	,
cord-006229-7yoilsho	189	24	to	to	TO
cord-006229-7yoilsho	189	25	detect	detect	VB
cord-006229-7yoilsho	189	26	early	early	JJ
cord-006229-7yoilsho	189	27	and	and	CC
cord-006229-7yoilsho	189	28	late	late	JJ
cord-006229-7yoilsho	189	29	metabolic	metabolic	JJ
cord-006229-7yoilsho	189	30	events	event	NNS
cord-006229-7yoilsho	189	31	after	after	IN
cord-006229-7yoilsho	189	32	frataxin	frataxin	NN
cord-006229-7yoilsho	189	33	disruption	disruption	NN
cord-006229-7yoilsho	189	34	.	.	.
cord-006229-7yoilsho	190	1	Therefore	therefore	RB
cord-006229-7yoilsho	190	2	we	-PRON-	PRP
cord-006229-7yoilsho	190	3	analysed	analyse	VBD
cord-006229-7yoilsho	190	4	the	the	DT
cord-006229-7yoilsho	190	5	mentioned	mention	VBN
cord-006229-7yoilsho	190	6	parameters	parameter	NNS
cord-006229-7yoilsho	190	7	(	(	-LRB-
cord-006229-7yoilsho	190	8	with	with	IN
cord-006229-7yoilsho	190	9	additional	additional	JJ
cord-006229-7yoilsho	190	10	ATP	ATP	NNP
cord-006229-7yoilsho	190	11	and	and	CC
cord-006229-7yoilsho	190	12	iron	iron	NN
cord-006229-7yoilsho	190	13	content	content	NN
cord-006229-7yoilsho	190	14	)	)	-RRB-
cord-006229-7yoilsho	190	15	in	in	IN
cord-006229-7yoilsho	190	16	parallel	parallel	NN
cord-006229-7yoilsho	190	17	at	at	IN
cord-006229-7yoilsho	190	18	day	day	NN
cord-006229-7yoilsho	190	19	3	3	CD
cord-006229-7yoilsho	190	20	,	,	,
cord-006229-7yoilsho	190	21	5	5	CD
cord-006229-7yoilsho	190	22	,	,	,
cord-006229-7yoilsho	190	23	7	7	CD
cord-006229-7yoilsho	190	24	and	and	CC
cord-006229-7yoilsho	190	25	10	10	CD
cord-006229-7yoilsho	190	26	and	and	CC
cord-006229-7yoilsho	190	27	could	could	MD
cord-006229-7yoilsho	190	28	identify	identify	VB
cord-006229-7yoilsho	190	29	an	an	DT
cord-006229-7yoilsho	190	30	initial	initial	JJ
cord-006229-7yoilsho	190	31	event	event	NN
cord-006229-7yoilsho	190	32	followed	follow	VBN
cord-006229-7yoilsho	190	33	by	by	IN
cord-006229-7yoilsho	190	34	secondary	secondary	JJ
cord-006229-7yoilsho	190	35	consequences	consequence	NNS
cord-006229-7yoilsho	190	36	and	and	CC
cord-006229-7yoilsho	190	37	parameters	parameter	NNS
cord-006229-7yoilsho	190	38	,	,	,
cord-006229-7yoilsho	190	39	which	which	WDT
cord-006229-7yoilsho	190	40	seem	seem	VBP
cord-006229-7yoilsho	190	41	to	to	TO
cord-006229-7yoilsho	190	42	play	play	VB
cord-006229-7yoilsho	190	43	only	only	RB
cord-006229-7yoilsho	190	44	a	a	DT
cord-006229-7yoilsho	190	45	minor	minor	JJ
cord-006229-7yoilsho	190	46	role	role	NN
cord-006229-7yoilsho	190	47	in	in	IN
cord-006229-7yoilsho	190	48	the	the	DT
cord-006229-7yoilsho	190	49	FRDA	FRDA	NNP
cord-006229-7yoilsho	190	50	pathogenesis	pathogenesis	NN
cord-006229-7yoilsho	190	51	.	.	.
cord-006229-7yoilsho	191	1	On	on	IN
cord-006229-7yoilsho	191	2	the	the	DT
cord-006229-7yoilsho	191	3	contrary	contrary	NN
cord-006229-7yoilsho	191	4	,	,	,
cord-006229-7yoilsho	191	5	a	a	DT
cord-006229-7yoilsho	191	6	partial	partial	JJ
cord-006229-7yoilsho	191	7	deficit	deficit	NN
cord-006229-7yoilsho	191	8	of	of	IN
cord-006229-7yoilsho	191	9	frataxin	frataxin	NN
cord-006229-7yoilsho	191	10	did	do	VBD
cord-006229-7yoilsho	191	11	n't	not	RB
cord-006229-7yoilsho	191	12	result	result	VB
cord-006229-7yoilsho	191	13	in	in	IN
cord-006229-7yoilsho	191	14	any	any	DT
cord-006229-7yoilsho	191	15	differences	difference	NNS
cord-006229-7yoilsho	191	16	over	over	IN
cord-006229-7yoilsho	191	17	time	time	NN
cord-006229-7yoilsho	191	18	and	and	CC
cord-006229-7yoilsho	191	19	suggests	suggest	VBZ
cord-006229-7yoilsho	191	20	that	that	IN
cord-006229-7yoilsho	191	21	there	there	EX
cord-006229-7yoilsho	191	22	are	be	VBP
cord-006229-7yoilsho	191	23	only	only	RB
cord-006229-7yoilsho	191	24	cellular	cellular	JJ
cord-006229-7yoilsho	191	25	alterations	alteration	NNS
cord-006229-7yoilsho	191	26	below	below	IN
cord-006229-7yoilsho	191	27	a	a	DT
cord-006229-7yoilsho	191	28	critical	critical	JJ
cord-006229-7yoilsho	191	29	threshold	threshold	NN
cord-006229-7yoilsho	191	30	.	.	.
cord-006229-7yoilsho	192	1	In	in	IN
cord-006229-7yoilsho	192	2	conclusion	conclusion	NN
cord-006229-7yoilsho	192	3	,	,	,
cord-006229-7yoilsho	192	4	our	-PRON-	PRP$
cord-006229-7yoilsho	192	5	new	new	JJ
cord-006229-7yoilsho	192	6	established	establish	VBN
cord-006229-7yoilsho	192	7	mammalian	mammalian	JJ
cord-006229-7yoilsho	192	8	cellular	cellular	JJ
cord-006229-7yoilsho	192	9	FRDA	FRDA	NNP
cord-006229-7yoilsho	192	10	model	model	NN
cord-006229-7yoilsho	192	11	mimics	mimic	VBZ
cord-006229-7yoilsho	192	12	typical	typical	JJ
cord-006229-7yoilsho	192	13	metabolic	metabolic	JJ
cord-006229-7yoilsho	192	14	consequences	consequence	NNS
cord-006229-7yoilsho	192	15	of	of	IN
cord-006229-7yoilsho	192	16	the	the	DT
cord-006229-7yoilsho	192	17	human	human	JJ
cord-006229-7yoilsho	192	18	disease	disease	NN
cord-006229-7yoilsho	192	19	and	and	CC
cord-006229-7yoilsho	192	20	seems	seem	VBZ
cord-006229-7yoilsho	192	21	to	to	TO
cord-006229-7yoilsho	192	22	be	be	VB
cord-006229-7yoilsho	192	23	qualified	qualified	JJ
cord-006229-7yoilsho	192	24	for	for	IN
cord-006229-7yoilsho	192	25	FRDA	FRDA	NNP
cord-006229-7yoilsho	192	26	research	research	NN
cord-006229-7yoilsho	192	27	.	.	.
cord-006229-7yoilsho	193	1	The	the	DT
cord-006229-7yoilsho	193	2	model	model	NN
cord-006229-7yoilsho	193	3	shows	show	VBZ
cord-006229-7yoilsho	193	4	for	for	IN
cord-006229-7yoilsho	193	5	the	the	DT
cord-006229-7yoilsho	193	6	first	first	JJ
cord-006229-7yoilsho	193	7	time	time	NN
cord-006229-7yoilsho	193	8	six	six	CD
cord-006229-7yoilsho	193	9	different	different	JJ
cord-006229-7yoilsho	193	10	metabolic	metabolic	JJ
cord-006229-7yoilsho	193	11	events	event	NNS
cord-006229-7yoilsho	193	12	in	in	IN
cord-006229-7yoilsho	193	13	the	the	DT
cord-006229-7yoilsho	193	14	course	course	NN
cord-006229-7yoilsho	193	15	of	of	IN
cord-006229-7yoilsho	193	16	time	time	NN
cord-006229-7yoilsho	193	17	in	in	IN
cord-006229-7yoilsho	193	18	parallel	parallel	NN
cord-006229-7yoilsho	193	19	and	and	CC
cord-006229-7yoilsho	193	20	reveals	reveal	VBZ
cord-006229-7yoilsho	193	21	insights	insight	NNS
cord-006229-7yoilsho	193	22	into	into	IN
cord-006229-7yoilsho	193	23	primary	primary	JJ
cord-006229-7yoilsho	193	24	and	and	CC
cord-006229-7yoilsho	193	25	secondary	secondary	JJ
cord-006229-7yoilsho	193	26	events	event	NNS
cord-006229-7yoilsho	193	27	of	of	IN
cord-006229-7yoilsho	193	28	FRDA	FRDA	NNP
cord-006229-7yoilsho	193	29	pathogenesis	pathogenesis	NN
cord-006229-7yoilsho	193	30	.	.	.
cord-006229-7yoilsho	194	1	These	these	DT
cord-006229-7yoilsho	194	2	observations	observation	NNS
cord-006229-7yoilsho	194	3	can	can	MD
cord-006229-7yoilsho	194	4	be	be	VB
cord-006229-7yoilsho	194	5	used	use	VBN
cord-006229-7yoilsho	194	6	to	to	TO
cord-006229-7yoilsho	194	7	better	well	RBR
cord-006229-7yoilsho	194	8	understand	understand	VB
cord-006229-7yoilsho	194	9	the	the	DT
cord-006229-7yoilsho	194	10	function	function	NN
cord-006229-7yoilsho	194	11	of	of	IN
cord-006229-7yoilsho	194	12	frataxin	frataxin	NN
cord-006229-7yoilsho	194	13	and	and	CC
cord-006229-7yoilsho	194	14	can	can	MD
cord-006229-7yoilsho	194	15	help	help	VB
cord-006229-7yoilsho	194	16	to	to	TO
cord-006229-7yoilsho	194	17	develop	develop	VB
cord-006229-7yoilsho	194	18	new	new	JJ
cord-006229-7yoilsho	194	19	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	194	20	strategies	strategy	NNS
cord-006229-7yoilsho	194	21	to	to	TO
cord-006229-7yoilsho	194	22	address	address	VB
cord-006229-7yoilsho	194	23	the	the	DT
cord-006229-7yoilsho	194	24	consequences	consequence	NNS
cord-006229-7yoilsho	194	25	of	of	IN
cord-006229-7yoilsho	194	26	frataxin	frataxin	JJ
cord-006229-7yoilsho	194	27	deficiency	deficiency	NN
cord-006229-7yoilsho	194	28	.	.	.
cord-006229-7yoilsho	195	1	Moreover	moreover	RB
cord-006229-7yoilsho	195	2	,	,	,
cord-006229-7yoilsho	195	3	the	the	DT
cord-006229-7yoilsho	195	4	transfer	transfer	NN
cord-006229-7yoilsho	195	5	of	of	IN
cord-006229-7yoilsho	195	6	this	this	DT
cord-006229-7yoilsho	195	7	cell	cell	NN
cord-006229-7yoilsho	195	8	model	model	NN
cord-006229-7yoilsho	195	9	into	into	IN
cord-006229-7yoilsho	195	10	96well	96well	CD
cord-006229-7yoilsho	195	11	plates	plate	NNS
cord-006229-7yoilsho	195	12	offers	offer	VBZ
cord-006229-7yoilsho	195	13	the	the	DT
cord-006229-7yoilsho	195	14	possibility	possibility	NN
cord-006229-7yoilsho	195	15	for	for	IN
cord-006229-7yoilsho	195	16	a	a	DT
cord-006229-7yoilsho	195	17	high	high	JJ
cord-006229-7yoilsho	195	18	-	-	HYPH
cord-006229-7yoilsho	195	19	throughput	throughput	NN
cord-006229-7yoilsho	195	20	screening	screening	NN
cord-006229-7yoilsho	195	21	of	of	IN
cord-006229-7yoilsho	195	22	potential	potential	JJ
cord-006229-7yoilsho	195	23	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	195	24	substances	substance	NNS
cord-006229-7yoilsho	195	25	.	.	.
cord-006229-7yoilsho	196	1	The	the	DT
cord-006229-7yoilsho	196	2	disease	disease	NN
cord-006229-7yoilsho	196	3	diphtheria	diphtheria	NN
cord-006229-7yoilsho	196	4	is	be	VBZ
cord-006229-7yoilsho	196	5	caused	cause	VBN
cord-006229-7yoilsho	196	6	by	by	IN
cord-006229-7yoilsho	196	7	the	the	DT
cord-006229-7yoilsho	196	8	diphtheria	diphtheria	NN
cord-006229-7yoilsho	196	9	toxin	toxin	NN
cord-006229-7yoilsho	196	10	(	(	-LRB-
cord-006229-7yoilsho	196	11	DT	DT	NNP
cord-006229-7yoilsho	196	12	)	)	-RRB-
cord-006229-7yoilsho	196	13	which	which	WDT
cord-006229-7yoilsho	196	14	belongs	belong	VBZ
cord-006229-7yoilsho	196	15	to	to	IN
cord-006229-7yoilsho	196	16	the	the	DT
cord-006229-7yoilsho	196	17	group	group	NN
cord-006229-7yoilsho	196	18	of	of	IN
cord-006229-7yoilsho	196	19	single	single	JJ
cord-006229-7yoilsho	196	20	-	-	HYPH
cord-006229-7yoilsho	196	21	chain	chain	NN
cord-006229-7yoilsho	196	22	AB	ab	NN
cord-006229-7yoilsho	196	23	-	-	HYPH
cord-006229-7yoilsho	196	24	type	type	NN
cord-006229-7yoilsho	196	25	bacterial	bacterial	JJ
cord-006229-7yoilsho	196	26	protein	protein	NN
cord-006229-7yoilsho	196	27	toxins	toxin	NNS
cord-006229-7yoilsho	196	28	.	.	.
cord-006229-7yoilsho	197	1	Receptor	receptor	NN
cord-006229-7yoilsho	197	2	-	-	HYPH
cord-006229-7yoilsho	197	3	binding	binding	NN
cord-006229-7yoilsho	197	4	of	of	IN
cord-006229-7yoilsho	197	5	the	the	DT
cord-006229-7yoilsho	197	6	B	b	NN
cord-006229-7yoilsho	197	7	-	-	HYPH
cord-006229-7yoilsho	197	8	domain	domain	NN
cord-006229-7yoilsho	197	9	on	on	IN
cord-006229-7yoilsho	197	10	the	the	DT
cord-006229-7yoilsho	197	11	target	target	NN
cord-006229-7yoilsho	197	12	cell	cell	NN
cord-006229-7yoilsho	197	13	surface	surface	NN
cord-006229-7yoilsho	197	14	is	be	VBZ
cord-006229-7yoilsho	197	15	followed	follow	VBN
cord-006229-7yoilsho	197	16	by	by	IN
cord-006229-7yoilsho	197	17	receptor	receptor	NN
cord-006229-7yoilsho	197	18	-	-	HYPH
cord-006229-7yoilsho	197	19	mediated	mediate	VBN
cord-006229-7yoilsho	197	20	endocytosis	endocytosis	NN
cord-006229-7yoilsho	197	21	and	and	CC
cord-006229-7yoilsho	197	22	internalization	internalization	NN
cord-006229-7yoilsho	197	23	into	into	IN
cord-006229-7yoilsho	197	24	early	early	JJ
cord-006229-7yoilsho	197	25	endosomal	endosomal	JJ
cord-006229-7yoilsho	197	26	vesicles	vesicle	NNS
cord-006229-7yoilsho	197	27	.	.	.
cord-006229-7yoilsho	198	1	Endosomal	Endosomal	NNP
cord-006229-7yoilsho	198	2	acidification	acidification	NN
cord-006229-7yoilsho	198	3	triggers	trigger	VBZ
cord-006229-7yoilsho	198	4	membrane	membrane	NN
cord-006229-7yoilsho	198	5	insertion	insertion	NN
cord-006229-7yoilsho	198	6	and	and	CC
cord-006229-7yoilsho	198	7	pore	pore	NN
cord-006229-7yoilsho	198	8	formation	formation	NN
cord-006229-7yoilsho	198	9	of	of	IN
cord-006229-7yoilsho	198	10	the	the	DT
cord-006229-7yoilsho	198	11	transmembrane	transmembrane	NN
cord-006229-7yoilsho	198	12	(	(	-LRB-
cord-006229-7yoilsho	198	13	T	T	NNP
cord-006229-7yoilsho	198	14	)	)	-RRB-
cord-006229-7yoilsho	198	15	domain	domain	NN
cord-006229-7yoilsho	198	16	together	together	RB
cord-006229-7yoilsho	198	17	with	with	IN
cord-006229-7yoilsho	198	18	translocation	translocation	NN
cord-006229-7yoilsho	198	19	of	of	IN
cord-006229-7yoilsho	198	20	the	the	DT
cord-006229-7yoilsho	198	21	(	(	-LRB-
cord-006229-7yoilsho	198	22	partially	partially	RB
cord-006229-7yoilsho	198	23	)	)	-RRB-
cord-006229-7yoilsho	198	24	unfolded	unfold	VBN
cord-006229-7yoilsho	198	25	catalytic	catalytic	JJ
cord-006229-7yoilsho	198	26	(	(	-LRB-
cord-006229-7yoilsho	198	27	C	c	NN
cord-006229-7yoilsho	198	28	)	)	-RRB-
cord-006229-7yoilsho	198	29	domain	domain	NN
cord-006229-7yoilsho	198	30	into	into	IN
cord-006229-7yoilsho	198	31	the	the	DT
cord-006229-7yoilsho	198	32	cytosol	cytosol	NN
cord-006229-7yoilsho	198	33	.	.	.
cord-006229-7yoilsho	199	1	Herein	herein	RB
cord-006229-7yoilsho	199	2	,	,	,
cord-006229-7yoilsho	199	3	DTA	DTA	NNP
cord-006229-7yoilsho	199	4	catalyzes	catalyze	VBZ
cord-006229-7yoilsho	199	5	ADP	adp	NN
cord-006229-7yoilsho	199	6	-	-	HYPH
cord-006229-7yoilsho	199	7	ribosylation	ribosylation	NN
cord-006229-7yoilsho	199	8	of	of	IN
cord-006229-7yoilsho	199	9	elongation	elongation	NN
cord-006229-7yoilsho	199	10	factor	factor	NN
cord-006229-7yoilsho	199	11	2	2	CD
cord-006229-7yoilsho	199	12	which	which	WDT
cord-006229-7yoilsho	199	13	leads	lead	VBZ
cord-006229-7yoilsho	199	14	to	to	IN
cord-006229-7yoilsho	199	15	disruption	disruption	NN
cord-006229-7yoilsho	199	16	of	of	IN
cord-006229-7yoilsho	199	17	protein	protein	NN
cord-006229-7yoilsho	199	18	synthesis	synthesis	NN
cord-006229-7yoilsho	199	19	and	and	CC
cord-006229-7yoilsho	199	20	finally	finally	RB
cord-006229-7yoilsho	199	21	causes	cause	VBZ
cord-006229-7yoilsho	199	22	cell	cell	NN
cord-006229-7yoilsho	199	23	death	death	NN
cord-006229-7yoilsho	199	24	[	[	-LRB-
cord-006229-7yoilsho	199	25	1	1	CD
cord-006229-7yoilsho	199	26	]	]	-RRB-
cord-006229-7yoilsho	199	27	.	.	.
cord-006229-7yoilsho	200	1	In	in	IN
cord-006229-7yoilsho	200	2	HeLa	HeLa	NNP
cord-006229-7yoilsho	200	3	cells	cell	NNS
cord-006229-7yoilsho	200	4	,	,	,
cord-006229-7yoilsho	200	5	these	these	DT
cord-006229-7yoilsho	200	6	events	event	NNS
cord-006229-7yoilsho	200	7	are	be	VBP
cord-006229-7yoilsho	200	8	related	relate	VBN
cord-006229-7yoilsho	200	9	to	to	IN
cord-006229-7yoilsho	200	10	cell	cell	NN
cord-006229-7yoilsho	200	11	-	-	HYPH
cord-006229-7yoilsho	200	12	rounding	rounding	NN
cord-006229-7yoilsho	200	13	functioning	function	VBG
cord-006229-7yoilsho	200	14	as	as	IN
cord-006229-7yoilsho	200	15	a	a	DT
cord-006229-7yoilsho	200	16	specific	specific	JJ
cord-006229-7yoilsho	200	17	endpoint	endpoint	NN
cord-006229-7yoilsho	200	18	to	to	TO
cord-006229-7yoilsho	200	19	monitor	monitor	VB
cord-006229-7yoilsho	200	20	the	the	DT
cord-006229-7yoilsho	200	21	uptake	uptake	NN
cord-006229-7yoilsho	200	22	of	of	IN
cord-006229-7yoilsho	200	23	DTA	DTA	NNP
cord-006229-7yoilsho	200	24	into	into	IN
cord-006229-7yoilsho	200	25	the	the	DT
cord-006229-7yoilsho	200	26	cytosol	cytosol	NN
cord-006229-7yoilsho	200	27	of	of	IN
cord-006229-7yoilsho	200	28	the	the	DT
cord-006229-7yoilsho	200	29	host	host	NN
cord-006229-7yoilsho	200	30	cell	cell	NN
cord-006229-7yoilsho	200	31	.	.	.
cord-006229-7yoilsho	201	1	As	as	IN
cord-006229-7yoilsho	201	2	for	for	IN
cord-006229-7yoilsho	201	3	other	other	JJ
cord-006229-7yoilsho	201	4	ADP	ADP	NNP
cord-006229-7yoilsho	201	5	-	-	HYPH
cord-006229-7yoilsho	201	6	ribosylating	ribosylate	VBG
cord-006229-7yoilsho	201	7	toxins	toxin	NNS
cord-006229-7yoilsho	201	8	such	such	JJ
cord-006229-7yoilsho	201	9	as	as	IN
cord-006229-7yoilsho	201	10	C.	C.	NNP
cord-006229-7yoilsho	201	11	botulinum	botulinum	NN
cord-006229-7yoilsho	201	12	C2	C2	NNP
cord-006229-7yoilsho	201	13	toxin	toxin	NN
cord-006229-7yoilsho	201	14	,	,	,
cord-006229-7yoilsho	201	15	C.	C.	NNP
cord-006229-7yoilsho	201	16	perfringens	perfringens	NN
cord-006229-7yoilsho	201	17	iota	iota	NN
cord-006229-7yoilsho	201	18	toxin	toxin	NN
cord-006229-7yoilsho	201	19	and	and	CC
cord-006229-7yoilsho	201	20	C.	C.	NNP
cord-006229-7yoilsho	201	21	difficile	difficile	NN
cord-006229-7yoilsho	201	22	CDT	CDT	NNP
cord-006229-7yoilsho	201	23	,	,	,
cord-006229-7yoilsho	201	24	also	also	RB
cord-006229-7yoilsho	201	25	in	in	IN
cord-006229-7yoilsho	201	26	case	case	NN
cord-006229-7yoilsho	201	27	of	of	IN
cord-006229-7yoilsho	201	28	native	native	JJ
cord-006229-7yoilsho	201	29	DT	DT	NNP
cord-006229-7yoilsho	201	30	we	-PRON-	PRP
cord-006229-7yoilsho	201	31	demonstrated	demonstrate	VBD
cord-006229-7yoilsho	201	32	the	the	DT
cord-006229-7yoilsho	201	33	involvement	involvement	NN
cord-006229-7yoilsho	201	34	of	of	IN
cord-006229-7yoilsho	201	35	several	several	JJ
cord-006229-7yoilsho	201	36	host	host	NN
cord-006229-7yoilsho	201	37	cell	cell	NN
cord-006229-7yoilsho	201	38	factors	factor	NNS
cord-006229-7yoilsho	201	39	during	during	IN
cord-006229-7yoilsho	201	40	the	the	DT
cord-006229-7yoilsho	201	41	translocation	translocation	NN
cord-006229-7yoilsho	201	42	step	step	NN
cord-006229-7yoilsho	201	43	of	of	IN
cord-006229-7yoilsho	201	44	the	the	DT
cord-006229-7yoilsho	201	45	catalytic	catalytic	JJ
cord-006229-7yoilsho	201	46	domain	domain	NN
cord-006229-7yoilsho	201	47	across	across	IN
cord-006229-7yoilsho	201	48	the	the	DT
cord-006229-7yoilsho	201	49	endosomal	endosomal	NNP
cord-006229-7yoilsho	201	50	membrane	membrane	NN
cord-006229-7yoilsho	201	51	[	[	-LRB-
cord-006229-7yoilsho	201	52	2	2	CD
cord-006229-7yoilsho	201	53	,	,	,
cord-006229-7yoilsho	201	54	3	3	CD
cord-006229-7yoilsho	201	55	]	]	-RRB-
cord-006229-7yoilsho	201	56	.	.	.
cord-006229-7yoilsho	202	1	In	in	IN
cord-006229-7yoilsho	202	2	detail	detail	NN
cord-006229-7yoilsho	202	3	,	,	,
cord-006229-7yoilsho	202	4	we	-PRON-	PRP
cord-006229-7yoilsho	202	5	confirmed	confirm	VBD
cord-006229-7yoilsho	202	6	the	the	DT
cord-006229-7yoilsho	202	7	involvement	involvement	NN
cord-006229-7yoilsho	202	8	of	of	IN
cord-006229-7yoilsho	202	9	the	the	DT
cord-006229-7yoilsho	202	10	host	host	NN
cord-006229-7yoilsho	202	11	cell	cell	NN
cord-006229-7yoilsho	202	12	chaperone	chaperone	NN
cord-006229-7yoilsho	202	13	Hsp90	Hsp90	NNP
cord-006229-7yoilsho	202	14	and	and	CC
cord-006229-7yoilsho	202	15	the	the	DT
cord-006229-7yoilsho	202	16	thioredoxin	thioredoxin	JJ
cord-006229-7yoilsho	202	17	reductase	reductase	NN
cord-006229-7yoilsho	202	18	(	(	-LRB-
cord-006229-7yoilsho	202	19	TrxR	TrxR	NNP
cord-006229-7yoilsho	202	20	)	)	-RRB-
cord-006229-7yoilsho	202	21	,	,	,
cord-006229-7yoilsho	202	22	the	the	DT
cord-006229-7yoilsho	202	23	latter	latter	JJ
cord-006229-7yoilsho	202	24	presumably	presumably	RB
cord-006229-7yoilsho	202	25	responsible	responsible	JJ
cord-006229-7yoilsho	202	26	for	for	IN
cord-006229-7yoilsho	202	27	the	the	DT
cord-006229-7yoilsho	202	28	reduction	reduction	NN
cord-006229-7yoilsho	202	29	of	of	IN
cord-006229-7yoilsho	202	30	the	the	DT
cord-006229-7yoilsho	202	31	interchain	interchain	JJ
cord-006229-7yoilsho	202	32	disulfide	disulfide	NN
cord-006229-7yoilsho	202	33	bond	bond	NN
cord-006229-7yoilsho	202	34	between	between	IN
cord-006229-7yoilsho	202	35	the	the	DT
cord-006229-7yoilsho	202	36	DTA	DTA	NNP
cord-006229-7yoilsho	202	37	and	and	CC
cord-006229-7yoilsho	202	38	DTB	DTB	NNP
cord-006229-7yoilsho	202	39	moieties	moiety	NNS
cord-006229-7yoilsho	202	40	[	[	-LRB-
cord-006229-7yoilsho	202	41	4	4	CD
cord-006229-7yoilsho	202	42	,	,	,
cord-006229-7yoilsho	202	43	5	5	CD
cord-006229-7yoilsho	202	44	,	,	,
cord-006229-7yoilsho	202	45	6	6	CD
cord-006229-7yoilsho	202	46	]	]	-RRB-
cord-006229-7yoilsho	202	47	.	.	.
cord-006229-7yoilsho	203	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	203	2	,	,	,
cord-006229-7yoilsho	203	3	we	-PRON-	PRP
cord-006229-7yoilsho	203	4	identified	identify	VBD
cord-006229-7yoilsho	203	5	another	another	DT
cord-006229-7yoilsho	203	6	group	group	NN
cord-006229-7yoilsho	203	7	of	of	IN
cord-006229-7yoilsho	203	8	protein	protein	NN
cord-006229-7yoilsho	203	9	folding	folding	NN
cord-006229-7yoilsho	203	10	helpers	helper	NNS
cord-006229-7yoilsho	203	11	,	,	,
cord-006229-7yoilsho	203	12	the	the	DT
cord-006229-7yoilsho	203	13	family	family	NN
cord-006229-7yoilsho	203	14	of	of	IN
cord-006229-7yoilsho	203	15	peptidyl	peptidyl	NNP
cord-006229-7yoilsho	203	16	-	-	HYPH
cord-006229-7yoilsho	203	17	prolyl	prolyl	NNP
cord-006229-7yoilsho	203	18	cis	cis	NNP
cord-006229-7yoilsho	203	19	/	/	SYM
cord-006229-7yoilsho	203	20	trans	trans	NNP
cord-006229-7yoilsho	203	21	isomerases	isomerases	NNP
cord-006229-7yoilsho	203	22	(	(	-LRB-
cord-006229-7yoilsho	203	23	PPIases	PPIases	NNP
cord-006229-7yoilsho	203	24	)	)	-RRB-
cord-006229-7yoilsho	203	25	including	include	VBG
cord-006229-7yoilsho	203	26	cyclophilin	cyclophilin	NNP
cord-006229-7yoilsho	203	27	A	A	NNP
cord-006229-7yoilsho	203	28	(	(	-LRB-
cord-006229-7yoilsho	203	29	CypA	CypA	NNP
cord-006229-7yoilsho	203	30	)	)	-RRB-
cord-006229-7yoilsho	203	31	,	,	,
cord-006229-7yoilsho	203	32	Cyp40	Cyp40	NNP
cord-006229-7yoilsho	203	33	and	and	CC
cord-006229-7yoilsho	203	34	FK506-binding	fk506-binde	VBG
cord-006229-7yoilsho	203	35	protein	protein	NN
cord-006229-7yoilsho	203	36	(	(	-LRB-
cord-006229-7yoilsho	203	37	FKBP)51	fkbp)51	JJ
cord-006229-7yoilsho	203	38	as	as	RB
cord-006229-7yoilsho	203	39	required	require	VBN
cord-006229-7yoilsho	203	40	cytosolic	cytosolic	JJ
cord-006229-7yoilsho	203	41	factors	factor	NNS
cord-006229-7yoilsho	203	42	for	for	IN
cord-006229-7yoilsho	203	43	DTA	DTA	NNP
cord-006229-7yoilsho	203	44	translocation	translocation	NN
cord-006229-7yoilsho	203	45	.	.	.
cord-006229-7yoilsho	204	1	To	to	TO
cord-006229-7yoilsho	204	2	characterize	characterize	VB
cord-006229-7yoilsho	204	3	the	the	DT
cord-006229-7yoilsho	204	4	role	role	NN
cord-006229-7yoilsho	204	5	of	of	IN
cord-006229-7yoilsho	204	6	the	the	DT
cord-006229-7yoilsho	204	7	protein	protein	NN
cord-006229-7yoilsho	204	8	folding	fold	VBG
cord-006229-7yoilsho	204	9	helpers	helper	NNS
cord-006229-7yoilsho	204	10	in	in	IN
cord-006229-7yoilsho	204	11	more	more	JJR
cord-006229-7yoilsho	204	12	detail	detail	NN
cord-006229-7yoilsho	204	13	,	,	,
cord-006229-7yoilsho	204	14	we	-PRON-	PRP
cord-006229-7yoilsho	204	15	investigated	investigate	VBD
cord-006229-7yoilsho	204	16	their	-PRON-	PRP$
cord-006229-7yoilsho	204	17	interaction	interaction	NN
cord-006229-7yoilsho	204	18	with	with	IN
cord-006229-7yoilsho	204	19	purified	purify	VBN
cord-006229-7yoilsho	204	20	DTA	DTA	NNP
cord-006229-7yoilsho	204	21	in	in	IN
cord-006229-7yoilsho	204	22	vitro	vitro	FW
cord-006229-7yoilsho	204	23	by	by	IN
cord-006229-7yoilsho	204	24	performing	perform	VBG
cord-006229-7yoilsho	204	25	dot	dot	NN
cord-006229-7yoilsho	204	26	blot	blot	NN
cord-006229-7yoilsho	204	27	analysis	analysis	NN
cord-006229-7yoilsho	204	28	with	with	IN
cord-006229-7yoilsho	204	29	immobilized	immobilize	VBN
cord-006229-7yoilsho	204	30	recombinant	recombinant	JJ
cord-006229-7yoilsho	204	31	host	host	NN
cord-006229-7yoilsho	204	32	cell	cell	NN
cord-006229-7yoilsho	204	33	factors	factor	NNS
cord-006229-7yoilsho	204	34	,	,	,
cord-006229-7yoilsho	204	35	co	co	NN
cord-006229-7yoilsho	204	36	-	-	NN
cord-006229-7yoilsho	204	37	precipitation	precipitation	NN
cord-006229-7yoilsho	204	38	of	of	IN
cord-006229-7yoilsho	204	39	cellular	cellular	JJ
cord-006229-7yoilsho	204	40	factors	factor	NNS
cord-006229-7yoilsho	204	41	with	with	IN
cord-006229-7yoilsho	204	42	DTA	DTA	NNP
cord-006229-7yoilsho	204	43	from	from	IN
cord-006229-7yoilsho	204	44	HeLa	HeLa	NNP
cord-006229-7yoilsho	204	45	lysate	lysate	NN
cord-006229-7yoilsho	204	46	and	and	CC
cord-006229-7yoilsho	204	47	isothermal	isothermal	JJ
cord-006229-7yoilsho	204	48	titration	titration	NN
cord-006229-7yoilsho	204	49	calorimetry	calorimetry	NN
cord-006229-7yoilsho	204	50	with	with	IN
cord-006229-7yoilsho	204	51	purified	purify	VBN
cord-006229-7yoilsho	204	52	proteins	protein	NNS
cord-006229-7yoilsho	204	53	therewith	therewith	IN
cord-006229-7yoilsho	204	54	determining	determine	VBG
cord-006229-7yoilsho	204	55	the	the	DT
cord-006229-7yoilsho	204	56	thermodynamic	thermodynamic	JJ
cord-006229-7yoilsho	204	57	parameters	parameter	NNS
cord-006229-7yoilsho	204	58	of	of	IN
cord-006229-7yoilsho	204	59	the	the	DT
cord-006229-7yoilsho	204	60	individual	individual	JJ
cord-006229-7yoilsho	204	61	binding	bind	VBG
cord-006229-7yoilsho	204	62	events	event	NNS
cord-006229-7yoilsho	204	63	.	.	.
cord-006229-7yoilsho	205	1	Thereby	thereby	RB
cord-006229-7yoilsho	205	2	,	,	,
cord-006229-7yoilsho	205	3	we	-PRON-	PRP
cord-006229-7yoilsho	205	4	detected	detect	VBD
cord-006229-7yoilsho	205	5	binding	bind	VBG
cord-006229-7yoilsho	205	6	of	of	IN
cord-006229-7yoilsho	205	7	DTA	DTA	NNP
cord-006229-7yoilsho	205	8	to	to	IN
cord-006229-7yoilsho	205	9	Hsp90	Hsp90	NNP
cord-006229-7yoilsho	205	10	,	,	,
cord-006229-7yoilsho	205	11	CypA	CypA	NNP
cord-006229-7yoilsho	205	12	,	,	,
cord-006229-7yoilsho	205	13	Cyp40	Cyp40	NNP
cord-006229-7yoilsho	205	14	,	,	,
cord-006229-7yoilsho	205	15	FKBP51	FKBP51	NNP
cord-006229-7yoilsho	205	16	and	and	CC
cord-006229-7yoilsho	205	17	FKBP52	FKBP52	NNP
cord-006229-7yoilsho	205	18	.	.	.
cord-006229-7yoilsho	206	1	The	the	DT
cord-006229-7yoilsho	206	2	data	datum	NNS
cord-006229-7yoilsho	206	3	increase	increase	VBP
cord-006229-7yoilsho	206	4	the	the	DT
cord-006229-7yoilsho	206	5	knowledge	knowledge	NN
cord-006229-7yoilsho	206	6	of	of	IN
cord-006229-7yoilsho	206	7	the	the	DT
cord-006229-7yoilsho	206	8	molecular	molecular	JJ
cord-006229-7yoilsho	206	9	mechanisms	mechanism	NNS
cord-006229-7yoilsho	206	10	underlying	underlie	VBG
cord-006229-7yoilsho	206	11	DT	DT	NNP
cord-006229-7yoilsho	206	12	uptake	uptake	NN
cord-006229-7yoilsho	206	13	and	and	CC
cord-006229-7yoilsho	206	14	especially	especially	RB
cord-006229-7yoilsho	206	15	DTA	DTA	NNP
cord-006229-7yoilsho	206	16	translocation	translocation	NN
cord-006229-7yoilsho	206	17	which	which	WDT
cord-006229-7yoilsho	206	18	can	can	MD
cord-006229-7yoilsho	206	19	be	be	VB
cord-006229-7yoilsho	206	20	medically	medically	RB
cord-006229-7yoilsho	206	21	used	use	VBN
cord-006229-7yoilsho	206	22	to	to	TO
cord-006229-7yoilsho	206	23	develop	develop	VB
cord-006229-7yoilsho	206	24	novel	novel	JJ
cord-006229-7yoilsho	206	25	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	206	26	strategies	strategy	NNS
cord-006229-7yoilsho	206	27	against	against	IN
cord-006229-7yoilsho	206	28	the	the	DT
cord-006229-7yoilsho	206	29	disease	disease	NN
cord-006229-7yoilsho	206	30	diphtheria	diphtheria	NN
cord-006229-7yoilsho	206	31	.	.	.
cord-006229-7yoilsho	207	1	[	[	-LRB-
cord-006229-7yoilsho	207	2	1	1	CD
cord-006229-7yoilsho	207	3	]	]	-RRB-
cord-006229-7yoilsho	207	4	Murphy	Murphy	NNP
cord-006229-7yoilsho	207	5	(	(	-LRB-
cord-006229-7yoilsho	207	6	2011	2011	CD
cord-006229-7yoilsho	207	7	)	)	-RRB-
cord-006229-7yoilsho	207	8	Toxins	toxin	NNS
cord-006229-7yoilsho	207	9	3	3	CD
cord-006229-7yoilsho	207	10	,	,	,
cord-006229-7yoilsho	207	11	294	294	CD
cord-006229-7yoilsho	207	12	-	-	SYM
cord-006229-7yoilsho	207	13	308	308	CD
cord-006229-7yoilsho	207	14	.	.	.
cord-006229-7yoilsho	208	1	[	[	-LRB-
cord-006229-7yoilsho	208	2	2	2	CD
cord-006229-7yoilsho	208	3	]	]	-RRB-
cord-006229-7yoilsho	208	4	Barth	Barth	NNP
cord-006229-7yoilsho	208	5	(	(	-LRB-
cord-006229-7yoilsho	208	6	2011	2011	CD
cord-006229-7yoilsho	208	7	)	)	-RRB-
cord-006229-7yoilsho	209	1	Naunyn	Naunyn	NNP
cord-006229-7yoilsho	209	2	-	-	HYPH
cord-006229-7yoilsho	209	3	Schmied	Schmied	NNP
cord-006229-7yoilsho	209	4	Arch	Arch	NNP
cord-006229-7yoilsho	209	5	Pharmacol	Pharmacol	NNP
cord-006229-7yoilsho	209	6	383	383	CD
cord-006229-7yoilsho	209	7	,	,	,
cord-006229-7yoilsho	209	8	237	237	CD
cord-006229-7yoilsho	209	9	-	-	SYM
cord-006229-7yoilsho	209	10	245	245	CD
cord-006229-7yoilsho	209	11	.	.	.
cord-006229-7yoilsho	210	1	[	[	-LRB-
cord-006229-7yoilsho	210	2	3	3	CD
cord-006229-7yoilsho	210	3	]	]	-RRB-
cord-006229-7yoilsho	210	4	Kaiser	Kaiser	NNP
cord-006229-7yoilsho	210	5	et	et	NNP
cord-006229-7yoilsho	210	6	al	al	NNP
cord-006229-7yoilsho	210	7	.	.	.
cord-006229-7yoilsho	211	1	(	(	-LRB-
cord-006229-7yoilsho	211	2	2012	2012	CD
cord-006229-7yoilsho	211	3	)	)	-RRB-
cord-006229-7yoilsho	211	4	Cell	cell	NN
cord-006229-7yoilsho	211	5	.	.	.
cord-006229-7yoilsho	212	1	Microbiol	Microbiol	NNP
cord-006229-7yoilsho	212	2	.	.	.
cord-006229-7yoilsho	213	1	14	14	CD
cord-006229-7yoilsho	213	2	,	,	,
cord-006229-7yoilsho	213	3	1193	1193	CD
cord-006229-7yoilsho	213	4	-	-	SYM
cord-006229-7yoilsho	213	5	1205	1205	CD
cord-006229-7yoilsho	213	6	.	.	.
cord-006229-7yoilsho	214	1	[	[	-LRB-
cord-006229-7yoilsho	214	2	4	4	LS
cord-006229-7yoilsho	214	3	]	]	-RRB-
cord-006229-7yoilsho	214	4	Dmochewitz	Dmochewitz	NNP
cord-006229-7yoilsho	214	5	et	et	NNP
cord-006229-7yoilsho	214	6	al	al	NNP
cord-006229-7yoilsho	214	7	.	.	.
cord-006229-7yoilsho	215	1	(	(	-LRB-
cord-006229-7yoilsho	215	2	2011	2011	CD
cord-006229-7yoilsho	215	3	)	)	-RRB-
cord-006229-7yoilsho	215	4	Cell	cell	NN
cord-006229-7yoilsho	215	5	.	.	.
cord-006229-7yoilsho	216	1	Microbiol	Microbiol	NNP
cord-006229-7yoilsho	216	2	.	.	.
cord-006229-7yoilsho	217	1	13	13	CD
cord-006229-7yoilsho	217	2	,	,	,
cord-006229-7yoilsho	217	3	359	359	CD
cord-006229-7yoilsho	217	4	-	-	SYM
cord-006229-7yoilsho	217	5	373	373	CD
cord-006229-7yoilsho	217	6	.	.	.
cord-006229-7yoilsho	218	1	[	[	-LRB-
cord-006229-7yoilsho	218	2	5	5	CD
cord-006229-7yoilsho	218	3	]	]	-RRB-
cord-006229-7yoilsho	218	4	Ratts	Ratts	NNP
cord-006229-7yoilsho	218	5	et	et	FW
cord-006229-7yoilsho	218	6	al	al	NNP
cord-006229-7yoilsho	218	7	.	.	.
cord-006229-7yoilsho	219	1	(	(	-LRB-
cord-006229-7yoilsho	219	2	2003	2003	CD
cord-006229-7yoilsho	219	3	)	)	-RRB-
cord-006229-7yoilsho	220	1	J.	J.	NNP
cord-006229-7yoilsho	220	2	Cell	Cell	NNP
cord-006229-7yoilsho	220	3	Biol	Biol	NNP
cord-006229-7yoilsho	220	4	.	.	.
cord-006229-7yoilsho	221	1	160	160	CD
cord-006229-7yoilsho	221	2	,	,	,
cord-006229-7yoilsho	221	3	1139	1139	CD
cord-006229-7yoilsho	221	4	-	-	SYM
cord-006229-7yoilsho	221	5	1150	1150	CD
cord-006229-7yoilsho	221	6	.	.	.
cord-006229-7yoilsho	222	1	[	[	-LRB-
cord-006229-7yoilsho	222	2	6	6	CD
cord-006229-7yoilsho	222	3	]	]	-RRB-
cord-006229-7yoilsho	222	4	Schnell	Schnell	NNP
cord-006229-7yoilsho	222	5	et	et	FW
cord-006229-7yoilsho	222	6	al	al	NNP
cord-006229-7yoilsho	222	7	.	.	.
cord-006229-7yoilsho	223	1	(	(	-LRB-
cord-006229-7yoilsho	223	2	2015	2015	CD
cord-006229-7yoilsho	223	3	)	)	-RRB-
cord-006229-7yoilsho	224	1	Novel	novel	JJ
cord-006229-7yoilsho	224	2	afflictions	affliction	NNS
cord-006229-7yoilsho	224	3	as	as	IN
cord-006229-7yoilsho	224	4	for	for	IN
cord-006229-7yoilsho	224	5	example	example	NN
cord-006229-7yoilsho	224	6	Clostridium	clostridium	NN
cord-006229-7yoilsho	224	7	(	(	-LRB-
cord-006229-7yoilsho	224	8	C.	C.	NNP
cord-006229-7yoilsho	224	9	)	)	-RRB-
cord-006229-7yoilsho	224	10	difficile	difficile	NN
cord-006229-7yoilsho	224	11	associated	associate	VBD
cord-006229-7yoilsho	224	12	diseases	disease	NNS
cord-006229-7yoilsho	224	13	(	(	-LRB-
cord-006229-7yoilsho	224	14	CDAD	CDAD	NNP
cord-006229-7yoilsho	224	15	)	)	-RRB-
cord-006229-7yoilsho	224	16	caused	cause	VBN
cord-006229-7yoilsho	224	17	by	by	IN
cord-006229-7yoilsho	224	18	Clostridium	clostridium	NN
cord-006229-7yoilsho	224	19	difficile	difficile	NN
cord-006229-7yoilsho	224	20	are	be	VBP
cord-006229-7yoilsho	224	21	on	on	IN
cord-006229-7yoilsho	224	22	the	the	DT
cord-006229-7yoilsho	224	23	increase	increase	NN
cord-006229-7yoilsho	224	24	and	and	CC
cord-006229-7yoilsho	224	25	challenging	challenge	VBG
cord-006229-7yoilsho	224	26	to	to	TO
cord-006229-7yoilsho	224	27	treat	treat	VB
cord-006229-7yoilsho	224	28	.	.	.
cord-006229-7yoilsho	225	1	CDAD	CDAD	NNP
cord-006229-7yoilsho	225	2	most	most	RBS
cord-006229-7yoilsho	225	3	frequent	frequent	JJ
cord-006229-7yoilsho	225	4	occur	occur	VBP
cord-006229-7yoilsho	225	5	in	in	IN
cord-006229-7yoilsho	225	6	hospitalized	hospitalize	VBN
cord-006229-7yoilsho	225	7	patients	patient	NNS
cord-006229-7yoilsho	225	8	after	after	IN
cord-006229-7yoilsho	225	9	prolonged	prolong	VBN
cord-006229-7yoilsho	225	10	treatment	treatment	NN
cord-006229-7yoilsho	225	11	with	with	IN
cord-006229-7yoilsho	225	12	antibiotics	antibiotic	NNS
cord-006229-7yoilsho	225	13	.	.	.
cord-006229-7yoilsho	226	1	CDAD	CDAD	NNP
cord-006229-7yoilsho	226	2	includes	include	VBZ
cord-006229-7yoilsho	226	3	among	among	IN
cord-006229-7yoilsho	226	4	others	other	NNS
cord-006229-7yoilsho	226	5	diarrhea	diarrhea	JJ
cord-006229-7yoilsho	226	6	and	and	CC
cord-006229-7yoilsho	226	7	the	the	DT
cord-006229-7yoilsho	226	8	severe	severe	JJ
cord-006229-7yoilsho	226	9	form	form	NN
cord-006229-7yoilsho	226	10	of	of	IN
cord-006229-7yoilsho	226	11	pseudomembranous	pseudomembranous	JJ
cord-006229-7yoilsho	226	12	colitis	colitis	NN
cord-006229-7yoilsho	226	13	.	.	.
cord-006229-7yoilsho	227	1	Not	not	RB
cord-006229-7yoilsho	227	2	only	only	RB
cord-006229-7yoilsho	227	3	the	the	DT
cord-006229-7yoilsho	227	4	treatment	treatment	NN
cord-006229-7yoilsho	227	5	of	of	IN
cord-006229-7yoilsho	227	6	the	the	DT
cord-006229-7yoilsho	227	7	infection	infection	NN
cord-006229-7yoilsho	227	8	,	,	,
cord-006229-7yoilsho	227	9	but	but	CC
cord-006229-7yoilsho	227	10	also	also	RB
cord-006229-7yoilsho	227	11	the	the	DT
cord-006229-7yoilsho	227	12	treatment	treatment	NN
cord-006229-7yoilsho	227	13	of	of	IN
cord-006229-7yoilsho	227	14	the	the	DT
cord-006229-7yoilsho	227	15	toxins	toxin	NNS
cord-006229-7yoilsho	227	16	has	have	VBZ
cord-006229-7yoilsho	227	17	a	a	DT
cord-006229-7yoilsho	227	18	high	high	JJ
cord-006229-7yoilsho	227	19	clinical	clinical	JJ
cord-006229-7yoilsho	227	20	significance	significance	NN
cord-006229-7yoilsho	227	21	.	.	.
cord-006229-7yoilsho	228	1	C.	C.	NNP
cord-006229-7yoilsho	228	2	difficile	difficile	NN
cord-006229-7yoilsho	228	3	secretes	secrete	VBZ
cord-006229-7yoilsho	228	4	the	the	DT
cord-006229-7yoilsho	228	5	exotoxins	exotoxin	NNS
cord-006229-7yoilsho	228	6	A	A	NNP
cord-006229-7yoilsho	228	7	(	(	-LRB-
cord-006229-7yoilsho	228	8	TcdA	TcdA	NNP
cord-006229-7yoilsho	228	9	)	)	-RRB-
cord-006229-7yoilsho	228	10	and	and	CC
cord-006229-7yoilsho	228	11	B	B	NNP
cord-006229-7yoilsho	228	12	(	(	-LRB-
cord-006229-7yoilsho	228	13	TcdB	TcdB	NNP
cord-006229-7yoilsho	228	14	)	)	-RRB-
cord-006229-7yoilsho	228	15	,	,	,
cord-006229-7yoilsho	228	16	which	which	WDT
cord-006229-7yoilsho	228	17	glycosylate	glycosylate	NNP
cord-006229-7yoilsho	228	18	and	and	CC
cord-006229-7yoilsho	228	19	thereby	thereby	RB
cord-006229-7yoilsho	228	20	inactivate	inactivate	VB
cord-006229-7yoilsho	228	21	Rho	rho	NN
cord-006229-7yoilsho	228	22	-	-	HYPH
cord-006229-7yoilsho	228	23	GTPases	gtpase	NNS
cord-006229-7yoilsho	228	24	in	in	IN
cord-006229-7yoilsho	228	25	mammalian	mammalian	JJ
cord-006229-7yoilsho	228	26	cells	cell	NNS
cord-006229-7yoilsho	228	27	.	.	.
cord-006229-7yoilsho	229	1	TcdA	TcdA	NNP
cord-006229-7yoilsho	229	2	and	and	CC
cord-006229-7yoilsho	229	3	TcdB	TcdB	NNP
cord-006229-7yoilsho	229	4	are	be	VBP
cord-006229-7yoilsho	229	5	considered	consider	VBN
cord-006229-7yoilsho	229	6	as	as	IN
cord-006229-7yoilsho	229	7	the	the	DT
cord-006229-7yoilsho	229	8	causative	causative	JJ
cord-006229-7yoilsho	229	9	agents	agent	NNS
cord-006229-7yoilsho	229	10	of	of	IN
cord-006229-7yoilsho	229	11	CDAD	CDAD	NNP
cord-006229-7yoilsho	229	12	.	.	.
cord-006229-7yoilsho	230	1	In	in	IN
cord-006229-7yoilsho	230	2	the	the	DT
cord-006229-7yoilsho	230	3	last	last	JJ
cord-006229-7yoilsho	230	4	few	few	JJ
cord-006229-7yoilsho	230	5	years	year	NNS
cord-006229-7yoilsho	230	6	,	,	,
cord-006229-7yoilsho	230	7	more	more	JJR
cord-006229-7yoilsho	230	8	and	and	CC
cord-006229-7yoilsho	230	9	more	more	JJR
cord-006229-7yoilsho	230	10	hypervirulent	hypervirulent	JJ
cord-006229-7yoilsho	230	11	strains	strain	NNS
cord-006229-7yoilsho	230	12	of	of	IN
cord-006229-7yoilsho	230	13	C.	C.	NNP
cord-006229-7yoilsho	230	14	difficile	difficile	NNP
cord-006229-7yoilsho	230	15	were	be	VBD
cord-006229-7yoilsho	230	16	described	describe	VBN
cord-006229-7yoilsho	230	17	.	.	.
cord-006229-7yoilsho	231	1	In	in	IN
cord-006229-7yoilsho	231	2	these	these	DT
cord-006229-7yoilsho	231	3	hypervirulent	hypervirulent	NN
cord-006229-7yoilsho	231	4	strains	strain	NNS
cord-006229-7yoilsho	231	5	,	,	,
cord-006229-7yoilsho	231	6	the	the	DT
cord-006229-7yoilsho	231	7	ADP	ADP	NNP
cord-006229-7yoilsho	231	8	-	-	HYPH
cord-006229-7yoilsho	231	9	ribosyltransferase	ribosyltransferase	NNP
cord-006229-7yoilsho	231	10	CDT	CDT	NNP
cord-006229-7yoilsho	231	11	was	be	VBD
cord-006229-7yoilsho	231	12	found	find	VBN
cord-006229-7yoilsho	231	13	as	as	IN
cord-006229-7yoilsho	231	14	a	a	DT
cord-006229-7yoilsho	231	15	third	third	JJ
cord-006229-7yoilsho	231	16	toxin	toxin	NN
cord-006229-7yoilsho	231	17	in	in	IN
cord-006229-7yoilsho	231	18	addition	addition	NN
cord-006229-7yoilsho	231	19	to	to	IN
cord-006229-7yoilsho	231	20	TcdA	TcdA	NNP
cord-006229-7yoilsho	231	21	and	and	CC
cord-006229-7yoilsho	231	22	TcdB.	TcdB.	NNP
cord-006229-7yoilsho	232	1	Given	give	VBN
cord-006229-7yoilsho	232	2	the	the	DT
cord-006229-7yoilsho	232	3	lack	lack	NN
cord-006229-7yoilsho	232	4	of	of	IN
cord-006229-7yoilsho	232	5	agents	agent	NNS
cord-006229-7yoilsho	232	6	effective	effective	JJ
cord-006229-7yoilsho	232	7	against	against	IN
cord-006229-7yoilsho	232	8	antibiotic	antibiotic	JJ
cord-006229-7yoilsho	232	9	-	-	HYPH
cord-006229-7yoilsho	232	10	resistant	resistant	JJ
cord-006229-7yoilsho	232	11	bacterial	bacterial	JJ
cord-006229-7yoilsho	232	12	strains	strain	NNS
cord-006229-7yoilsho	232	13	and	and	CC
cord-006229-7yoilsho	232	14	bacterial	bacterial	JJ
cord-006229-7yoilsho	232	15	exotoxins	exotoxin	NNS
cord-006229-7yoilsho	232	16	,	,	,
cord-006229-7yoilsho	232	17	the	the	DT
cord-006229-7yoilsho	232	18	development	development	NN
cord-006229-7yoilsho	232	19	of	of	IN
cord-006229-7yoilsho	232	20	novel	novel	JJ
cord-006229-7yoilsho	232	21	pharmacological	pharmacological	JJ
cord-006229-7yoilsho	232	22	strategies	strategy	NNS
cord-006229-7yoilsho	232	23	is	be	VBZ
cord-006229-7yoilsho	232	24	needed	need	VBN
cord-006229-7yoilsho	232	25	.	.	.
cord-006229-7yoilsho	233	1	The	the	DT
cord-006229-7yoilsho	233	2	antimicrobial	antimicrobial	JJ
cord-006229-7yoilsho	233	3	activity	activity	NN
cord-006229-7yoilsho	233	4	of	of	IN
cord-006229-7yoilsho	233	5	naturally	naturally	RB
cord-006229-7yoilsho	233	6	occurring	occur	VBG
cord-006229-7yoilsho	233	7	substances	substance	NNS
cord-006229-7yoilsho	233	8	is	be	VBZ
cord-006229-7yoilsho	233	9	already	already	RB
cord-006229-7yoilsho	233	10	known	know	VBN
cord-006229-7yoilsho	233	11	for	for	IN
cord-006229-7yoilsho	233	12	a	a	DT
cord-006229-7yoilsho	233	13	long	long	JJ
cord-006229-7yoilsho	233	14	time	time	NN
cord-006229-7yoilsho	233	15	.	.	.
cord-006229-7yoilsho	234	1	One	one	CD
cord-006229-7yoilsho	234	2	important	important	JJ
cord-006229-7yoilsho	234	3	mechanism	mechanism	NN
cord-006229-7yoilsho	234	4	of	of	IN
cord-006229-7yoilsho	234	5	the	the	DT
cord-006229-7yoilsho	234	6	innate	innate	JJ
cord-006229-7yoilsho	234	7	immune	immune	JJ
cord-006229-7yoilsho	234	8	system	system	NN
cord-006229-7yoilsho	234	9	is	be	VBZ
cord-006229-7yoilsho	234	10	the	the	DT
cord-006229-7yoilsho	234	11	production	production	NN
cord-006229-7yoilsho	234	12	of	of	IN
cord-006229-7yoilsho	234	13	natural	natural	JJ
cord-006229-7yoilsho	234	14	peptides	peptide	NNS
cord-006229-7yoilsho	234	15	showing	show	VBG
cord-006229-7yoilsho	234	16	antibiotic	antibiotic	JJ
cord-006229-7yoilsho	234	17	features	feature	NNS
cord-006229-7yoilsho	234	18	.	.	.
cord-006229-7yoilsho	235	1	In	in	IN
cord-006229-7yoilsho	235	2	recent	recent	JJ
cord-006229-7yoilsho	235	3	years	year	NNS
cord-006229-7yoilsho	235	4	,	,	,
cord-006229-7yoilsho	235	5	it	-PRON-	PRP
cord-006229-7yoilsho	235	6	was	be	VBD
cord-006229-7yoilsho	235	7	shown	show	VBN
cord-006229-7yoilsho	235	8	that	that	IN
cord-006229-7yoilsho	235	9	human	human	JJ
cord-006229-7yoilsho	235	10	antimicrobial	antimicrobial	JJ
cord-006229-7yoilsho	235	11	peptides	peptide	NNS
cord-006229-7yoilsho	235	12	as	as	IN
cord-006229-7yoilsho	235	13	important	important	JJ
cord-006229-7yoilsho	235	14	part	part	NN
cord-006229-7yoilsho	235	15	of	of	IN
cord-006229-7yoilsho	235	16	the	the	DT
cord-006229-7yoilsho	235	17	native	native	JJ
cord-006229-7yoilsho	235	18	innate	innate	JJ
cord-006229-7yoilsho	235	19	immune	immune	JJ
cord-006229-7yoilsho	235	20	system	system	NN
cord-006229-7yoilsho	235	21	plays	play	VBZ
cord-006229-7yoilsho	235	22	a	a	DT
cord-006229-7yoilsho	235	23	crucial	crucial	JJ
cord-006229-7yoilsho	235	24	role	role	NN
cord-006229-7yoilsho	235	25	not	not	RB
cord-006229-7yoilsho	235	26	only	only	RB
cord-006229-7yoilsho	235	27	in	in	IN
cord-006229-7yoilsho	235	28	inactivation	inactivation	NN
cord-006229-7yoilsho	235	29	of	of	IN
cord-006229-7yoilsho	235	30	bacteria	bacteria	NNS
cord-006229-7yoilsho	235	31	but	but	CC
cord-006229-7yoilsho	235	32	also	also	RB
cord-006229-7yoilsho	235	33	in	in	IN
cord-006229-7yoilsho	235	34	inhibition	inhibition	NN
cord-006229-7yoilsho	235	35	of	of	IN
cord-006229-7yoilsho	235	36	bacterial	bacterial	JJ
cord-006229-7yoilsho	235	37	toxins	toxin	NNS
cord-006229-7yoilsho	235	38	(	(	-LRB-
cord-006229-7yoilsho	235	39	1	1	CD
cord-006229-7yoilsho	235	40	)	)	-RRB-
cord-006229-7yoilsho	235	41	.	.	.
cord-006229-7yoilsho	236	1	Prompted	prompt	VBN
cord-006229-7yoilsho	236	2	by	by	IN
cord-006229-7yoilsho	236	3	these	these	DT
cord-006229-7yoilsho	236	4	result	result	NN
cord-006229-7yoilsho	236	5	,	,	,
cord-006229-7yoilsho	236	6	we	-PRON-	PRP
cord-006229-7yoilsho	236	7	found	find	VBD
cord-006229-7yoilsho	236	8	that	that	IN
cord-006229-7yoilsho	236	9	only	only	JJ
cord-006229-7yoilsho	236	10	human	human	JJ
cord-006229-7yoilsho	236	11	α	α	NN
cord-006229-7yoilsho	236	12	-	-	HYPH
cord-006229-7yoilsho	236	13	defensin-1	defensin-1	NNP
cord-006229-7yoilsho	236	14	(	(	-LRB-
cord-006229-7yoilsho	236	15	HNP-1	HNP-1	NNP
cord-006229-7yoilsho	236	16	)	)	-RRB-
cord-006229-7yoilsho	236	17	but	but	CC
cord-006229-7yoilsho	236	18	not	not	RB
cord-006229-7yoilsho	236	19	human	human	JJ
cord-006229-7yoilsho	236	20	β	β	NN
cord-006229-7yoilsho	236	21	-	-	HYPH
cord-006229-7yoilsho	236	22	defensin-1	defensin-1	NNP
cord-006229-7yoilsho	236	23	(	(	-LRB-
cord-006229-7yoilsho	236	24	hBD-1	hBD-1	NNP
cord-006229-7yoilsho	236	25	)	)	-RRB-
cord-006229-7yoilsho	236	26	,	,	,
cord-006229-7yoilsho	236	27	both	both	DT
cord-006229-7yoilsho	236	28	important	important	JJ
cord-006229-7yoilsho	236	29	effectors	effector	NNS
cord-006229-7yoilsho	236	30	of	of	IN
cord-006229-7yoilsho	236	31	the	the	DT
cord-006229-7yoilsho	236	32	innate	innate	JJ
cord-006229-7yoilsho	236	33	immune	immune	JJ
cord-006229-7yoilsho	236	34	system	system	NN
cord-006229-7yoilsho	236	35	,	,	,
cord-006229-7yoilsho	236	36	protected	protect	VBN
cord-006229-7yoilsho	236	37	cultured	cultured	JJ
cord-006229-7yoilsho	236	38	epithelial	epithelial	JJ
cord-006229-7yoilsho	236	39	cells	cell	NNS
cord-006229-7yoilsho	236	40	from	from	IN
cord-006229-7yoilsho	236	41	intoxication	intoxication	NN
cord-006229-7yoilsho	236	42	with	with	IN
cord-006229-7yoilsho	236	43	TcdA	TcdA	NNP
cord-006229-7yoilsho	236	44	and	and	CC
cord-006229-7yoilsho	236	45	CDT	CDT	NNP
cord-006229-7yoilsho	236	46	when	when	WRB
cord-006229-7yoilsho	236	47	applied	apply	VBD
cord-006229-7yoilsho	236	48	prior	prior	RB
cord-006229-7yoilsho	236	49	to	to	IN
cord-006229-7yoilsho	236	50	the	the	DT
cord-006229-7yoilsho	236	51	toxins	toxin	NNS
cord-006229-7yoilsho	236	52	to	to	IN
cord-006229-7yoilsho	236	53	the	the	DT
cord-006229-7yoilsho	236	54	cells	cell	NNS
cord-006229-7yoilsho	236	55	.	.	.
cord-006229-7yoilsho	237	1	Moreover	moreover	RB
cord-006229-7yoilsho	237	2	,	,	,
cord-006229-7yoilsho	237	3	α	α	NN
cord-006229-7yoilsho	237	4	-	-	HYPH
cord-006229-7yoilsho	237	5	defensin-1	defensin-1	NNP
cord-006229-7yoilsho	237	6	prevented	prevent	VBD
cord-006229-7yoilsho	237	7	also	also	RB
cord-006229-7yoilsho	237	8	the	the	DT
cord-006229-7yoilsho	237	9	cytotoxic	cytotoxic	JJ
cord-006229-7yoilsho	237	10	effects	effect	NNS
cord-006229-7yoilsho	237	11	of	of	IN
cord-006229-7yoilsho	237	12	all	all	DT
cord-006229-7yoilsho	237	13	three	three	CD
cord-006229-7yoilsho	237	14	C.	C.	NNP
cord-006229-7yoilsho	237	15	difficile	difficile	NN
cord-006229-7yoilsho	237	16	toxins	toxin	NNS
cord-006229-7yoilsho	238	1	TcdA	TcdA	NNP
cord-006229-7yoilsho	238	2	,	,	,
cord-006229-7yoilsho	238	3	TcdB	TcdB	NNP
cord-006229-7yoilsho	238	4	and	and	CC
cord-006229-7yoilsho	238	5	CDT	CDT	NNP
cord-006229-7yoilsho	238	6	combined	combine	VBN
cord-006229-7yoilsho	238	7	in	in	IN
cord-006229-7yoilsho	238	8	the	the	DT
cord-006229-7yoilsho	238	9	medium	medium	NN
cord-006229-7yoilsho	238	10	.	.	.
cord-006229-7yoilsho	239	1	The	the	DT
cord-006229-7yoilsho	239	2	combined	combined	JJ
cord-006229-7yoilsho	239	3	investigation	investigation	NN
cord-006229-7yoilsho	239	4	of	of	IN
cord-006229-7yoilsho	239	5	all	all	DT
cord-006229-7yoilsho	239	6	three	three	CD
cord-006229-7yoilsho	239	7	toxins	toxin	NNS
cord-006229-7yoilsho	239	8	might	may	MD
cord-006229-7yoilsho	239	9	be	be	VB
cord-006229-7yoilsho	239	10	even	even	RB
cord-006229-7yoilsho	239	11	more	more	RBR
cord-006229-7yoilsho	239	12	suitable	suitable	JJ
cord-006229-7yoilsho	239	13	to	to	TO
cord-006229-7yoilsho	239	14	mimic	mimic	VB
cord-006229-7yoilsho	239	15	the	the	DT
cord-006229-7yoilsho	239	16	situation	situation	NN
cord-006229-7yoilsho	239	17	after	after	IN
cord-006229-7yoilsho	239	18	an	an	DT
cord-006229-7yoilsho	239	19	infection	infection	NN
cord-006229-7yoilsho	239	20	with	with	IN
cord-006229-7yoilsho	239	21	hypervirulent	hypervirulent	NN
cord-006229-7yoilsho	239	22	C.	C.	NNP
cord-006229-7yoilsho	239	23	difficile	difficile	NN
cord-006229-7yoilsho	239	24	.	.	.
cord-006229-7yoilsho	240	1	The	the	DT
cord-006229-7yoilsho	240	2	inhibition	inhibition	NN
cord-006229-7yoilsho	240	3	of	of	IN
cord-006229-7yoilsho	240	4	the	the	DT
cord-006229-7yoilsho	240	5	toxins	toxin	NNS
cord-006229-7yoilsho	240	6	was	be	VBD
cord-006229-7yoilsho	240	7	monitored	monitor	VBN
cord-006229-7yoilsho	240	8	by	by	IN
cord-006229-7yoilsho	240	9	cell	cell	NN
cord-006229-7yoilsho	240	10	rounding	rounding	NN
cord-006229-7yoilsho	240	11	caused	cause	VBN
cord-006229-7yoilsho	240	12	by	by	IN
cord-006229-7yoilsho	240	13	each	each	DT
cord-006229-7yoilsho	240	14	of	of	IN
cord-006229-7yoilsho	240	15	the	the	DT
cord-006229-7yoilsho	240	16	toxins	toxin	NNS
cord-006229-7yoilsho	240	17	.	.	.
cord-006229-7yoilsho	241	1	Currently	currently	RB
cord-006229-7yoilsho	241	2	,	,	,
cord-006229-7yoilsho	241	3	the	the	DT
cord-006229-7yoilsho	241	4	molecular	molecular	JJ
cord-006229-7yoilsho	241	5	mechanisms	mechanism	NNS
cord-006229-7yoilsho	241	6	underlying	underlie	VBG
cord-006229-7yoilsho	241	7	the	the	DT
cord-006229-7yoilsho	241	8	inhibitory	inhibitory	JJ
cord-006229-7yoilsho	241	9	effects	effect	NNS
cord-006229-7yoilsho	241	10	are	be	VBP
cord-006229-7yoilsho	241	11	still	still	RB
cord-006229-7yoilsho	241	12	unknown	unknown	JJ
cord-006229-7yoilsho	241	13	and	and	CC
cord-006229-7yoilsho	241	14	will	will	MD
cord-006229-7yoilsho	241	15	be	be	VB
cord-006229-7yoilsho	241	16	investigated	investigate	VBN
cord-006229-7yoilsho	241	17	in	in	IN
cord-006229-7yoilsho	241	18	different	different	JJ
cord-006229-7yoilsho	241	19	cell	cell	NN
cord-006229-7yoilsho	241	20	lines	line	NNS
cord-006229-7yoilsho	241	21	.	.	.
cord-006229-7yoilsho	242	1	In	in	IN
cord-006229-7yoilsho	242	2	conclusion	conclusion	NN
cord-006229-7yoilsho	242	3	,	,	,
cord-006229-7yoilsho	242	4	our	-PRON-	PRP$
cord-006229-7yoilsho	242	5	results	result	NNS
cord-006229-7yoilsho	242	6	demonstrate	demonstrate	VBP
cord-006229-7yoilsho	242	7	that	that	IN
cord-006229-7yoilsho	242	8	HNP-1	HNP-1	NNP
cord-006229-7yoilsho	242	9	causes	cause	VBZ
cord-006229-7yoilsho	242	10	a	a	DT
cord-006229-7yoilsho	242	11	loss	loss	NN
cord-006229-7yoilsho	242	12	of	of	IN
cord-006229-7yoilsho	242	13	cytotoxicity	cytotoxicity	NN
cord-006229-7yoilsho	242	14	of	of	IN
cord-006229-7yoilsho	242	15	the	the	DT
cord-006229-7yoilsho	242	16	C.	C.	NNP
cord-006229-7yoilsho	242	17	difficile	difficile	NN
cord-006229-7yoilsho	242	18	toxins	toxin	NNS
cord-006229-7yoilsho	242	19	and	and	CC
cord-006229-7yoilsho	242	20	may	may	MD
cord-006229-7yoilsho	242	21	act	act	VB
cord-006229-7yoilsho	242	22	as	as	IN
cord-006229-7yoilsho	242	23	novel	novel	JJ
cord-006229-7yoilsho	242	24	drugs	drug	NNS
cord-006229-7yoilsho	242	25	to	to	TO
cord-006229-7yoilsho	242	26	cure	cure	VB
cord-006229-7yoilsho	242	27	C.	C.	NNP
cord-006229-7yoilsho	242	28	difficile	difficile	NN
cord-006229-7yoilsho	242	29	infections	infection	NNS
cord-006229-7yoilsho	242	30	that	that	WDT
cord-006229-7yoilsho	242	31	contribute	contribute	VBP
cord-006229-7yoilsho	242	32	to	to	IN
cord-006229-7yoilsho	242	33	CDAD	CDAD	NNP
cord-006229-7yoilsho	242	34	.	.	.
cord-006229-7yoilsho	243	1	Neurodegenerative	neurodegenerative	JJ
cord-006229-7yoilsho	243	2	diseases	disease	NNS
cord-006229-7yoilsho	243	3	like	like	IN
cord-006229-7yoilsho	243	4	Parkinson´s	parkinson´	NNS
cord-006229-7yoilsho	243	5	disease	disease	NN
cord-006229-7yoilsho	243	6	(	(	-LRB-
cord-006229-7yoilsho	243	7	PD	PD	NNP
cord-006229-7yoilsho	243	8	)	)	-RRB-
cord-006229-7yoilsho	243	9	are	be	VBP
cord-006229-7yoilsho	243	10	accompanied	accompany	VBN
cord-006229-7yoilsho	243	11	by	by	IN
cord-006229-7yoilsho	243	12	altered	altered	JJ
cord-006229-7yoilsho	243	13	gene	gene	NN
cord-006229-7yoilsho	243	14	expression	expression	NN
cord-006229-7yoilsho	243	15	levels	level	NNS
cord-006229-7yoilsho	243	16	in	in	IN
cord-006229-7yoilsho	243	17	the	the	DT
cord-006229-7yoilsho	243	18	brain	brain	NN
cord-006229-7yoilsho	243	19	.	.	.
cord-006229-7yoilsho	244	1	Recent	recent	JJ
cord-006229-7yoilsho	244	2	studies	study	NNS
cord-006229-7yoilsho	244	3	support	support	VBP
cord-006229-7yoilsho	244	4	a	a	DT
cord-006229-7yoilsho	244	5	role	role	NN
cord-006229-7yoilsho	244	6	of	of	IN
cord-006229-7yoilsho	244	7	regulatory	regulatory	JJ
cord-006229-7yoilsho	244	8	noncoding	noncoding	JJ
cord-006229-7yoilsho	244	9	RNAs	rna	NNS
cord-006229-7yoilsho	244	10	,	,	,
cord-006229-7yoilsho	244	11	such	such	JJ
cord-006229-7yoilsho	244	12	as	as	IN
cord-006229-7yoilsho	244	13	microRNAs	microRNAs	NNPS
cord-006229-7yoilsho	244	14	(	(	-LRB-
cord-006229-7yoilsho	244	15	miRNAs	miRNAs	NNP
cord-006229-7yoilsho	244	16	)	)	-RRB-
cord-006229-7yoilsho	244	17	,	,	,
cord-006229-7yoilsho	244	18	which	which	WDT
cord-006229-7yoilsho	244	19	silence	silence	VBP
cord-006229-7yoilsho	244	20	a	a	DT
cord-006229-7yoilsho	244	21	specific	specific	JJ
cord-006229-7yoilsho	244	22	set	set	NN
cord-006229-7yoilsho	244	23	of	of	IN
cord-006229-7yoilsho	244	24	mRNAs	mRNAs	NNPS
cord-006229-7yoilsho	244	25	at	at	IN
cord-006229-7yoilsho	244	26	the	the	DT
cord-006229-7yoilsho	244	27	post	post	JJ
cord-006229-7yoilsho	244	28	-	-	JJ
cord-006229-7yoilsho	244	29	transcriptional	transcriptional	JJ
cord-006229-7yoilsho	244	30	level	level	NN
cord-006229-7yoilsho	244	31	.	.	.
cord-006229-7yoilsho	245	1	Upon	upon	IN
cord-006229-7yoilsho	245	2	their	-PRON-	PRP$
cord-006229-7yoilsho	245	3	aberrant	aberrant	JJ
cord-006229-7yoilsho	245	4	expression	expression	NN
cord-006229-7yoilsho	245	5	,	,	,
cord-006229-7yoilsho	245	6	they	-PRON-	PRP
cord-006229-7yoilsho	245	7	are	be	VBP
cord-006229-7yoilsho	245	8	likely	likely	RB
cord-006229-7yoilsho	245	9	involved	involve	VBN
cord-006229-7yoilsho	245	10	in	in	IN
cord-006229-7yoilsho	245	11	the	the	DT
cord-006229-7yoilsho	245	12	pathophysiology	pathophysiology	NN
cord-006229-7yoilsho	245	13	of	of	IN
cord-006229-7yoilsho	245	14	specific	specific	JJ
cord-006229-7yoilsho	245	15	neuronal	neuronal	JJ
cord-006229-7yoilsho	245	16	loss	loss	NN
cord-006229-7yoilsho	245	17	.	.	.
cord-006229-7yoilsho	246	1	Manipulation	manipulation	NN
cord-006229-7yoilsho	246	2	of	of	IN
cord-006229-7yoilsho	246	3	neuronal	neuronal	JJ
cord-006229-7yoilsho	246	4	gene	gene	NN
cord-006229-7yoilsho	246	5	expression	expression	NN
cord-006229-7yoilsho	246	6	is	be	VBZ
cord-006229-7yoilsho	246	7	pivotal	pivotal	JJ
cord-006229-7yoilsho	246	8	for	for	IN
cord-006229-7yoilsho	246	9	understanding	understand	VBG
cord-006229-7yoilsho	246	10	the	the	DT
cord-006229-7yoilsho	246	11	function	function	NN
cord-006229-7yoilsho	246	12	of	of	IN
cord-006229-7yoilsho	246	13	proteins	protein	NNS
cord-006229-7yoilsho	246	14	and	and	CC
cord-006229-7yoilsho	246	15	the	the	DT
cord-006229-7yoilsho	246	16	development	development	NN
cord-006229-7yoilsho	246	17	of	of	IN
cord-006229-7yoilsho	246	18	new	new	JJ
cord-006229-7yoilsho	246	19	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	246	20	strategies	strategy	NNS
cord-006229-7yoilsho	246	21	.	.	.
cord-006229-7yoilsho	247	1	RNA	RNA	NNP
cord-006229-7yoilsho	247	2	interference	interference	NN
cord-006229-7yoilsho	247	3	(	(	-LRB-
cord-006229-7yoilsho	247	4	RNAi	RNAi	NNP
cord-006229-7yoilsho	247	5	)	)	-RRB-
cord-006229-7yoilsho	247	6	strategies	strategy	NNS
cord-006229-7yoilsho	247	7	can	can	MD
cord-006229-7yoilsho	247	8	be	be	VB
cord-006229-7yoilsho	247	9	employed	employ	VBN
cord-006229-7yoilsho	247	10	through	through	IN
cord-006229-7yoilsho	247	11	the	the	DT
cord-006229-7yoilsho	247	12	administration	administration	NN
cord-006229-7yoilsho	247	13	of	of	IN
cord-006229-7yoilsho	247	14	small	small	JJ
cord-006229-7yoilsho	247	15	interfering	interfere	VBG
cord-006229-7yoilsho	247	16	RNAs	rna	NNS
cord-006229-7yoilsho	247	17	(	(	-LRB-
cord-006229-7yoilsho	247	18	siRNA	siRNA	NNP
cord-006229-7yoilsho	247	19	)	)	-RRB-
cord-006229-7yoilsho	247	20	,	,	,
cord-006229-7yoilsho	247	21	which	which	WDT
cord-006229-7yoilsho	247	22	mediate	mediate	VBP
cord-006229-7yoilsho	247	23	the	the	DT
cord-006229-7yoilsho	247	24	specific	specific	JJ
cord-006229-7yoilsho	247	25	knockdown	knockdown	NN
cord-006229-7yoilsho	247	26	of	of	IN
cord-006229-7yoilsho	247	27	a	a	DT
cord-006229-7yoilsho	247	28	selected	select	VBN
cord-006229-7yoilsho	247	29	target	target	NN
cord-006229-7yoilsho	247	30	gene	gene	NN
cord-006229-7yoilsho	247	31	.	.	.
cord-006229-7yoilsho	248	1	However	however	RB
cord-006229-7yoilsho	248	2	,	,	,
cord-006229-7yoilsho	248	3	the	the	DT
cord-006229-7yoilsho	248	4	main	main	JJ
cord-006229-7yoilsho	248	5	challenge	challenge	NN
cord-006229-7yoilsho	248	6	is	be	VBZ
cord-006229-7yoilsho	248	7	the	the	DT
cord-006229-7yoilsho	248	8	delivery	delivery	NN
cord-006229-7yoilsho	248	9	of	of	IN
cord-006229-7yoilsho	248	10	these	these	DT
cord-006229-7yoilsho	248	11	RNAs	rna	NNS
cord-006229-7yoilsho	248	12	into	into	IN
cord-006229-7yoilsho	248	13	the	the	DT
cord-006229-7yoilsho	248	14	neurons	neuron	NNS
cord-006229-7yoilsho	248	15	of	of	IN
cord-006229-7yoilsho	248	16	interest	interest	NN
cord-006229-7yoilsho	248	17	.	.	.
cord-006229-7yoilsho	249	1	In	in	IN
cord-006229-7yoilsho	249	2	this	this	DT
cord-006229-7yoilsho	249	3	pilot	pilot	NN
cord-006229-7yoilsho	249	4	study	study	NN
cord-006229-7yoilsho	249	5	,	,	,
cord-006229-7yoilsho	249	6	we	-PRON-	PRP
cord-006229-7yoilsho	249	7	present	present	VBP
cord-006229-7yoilsho	249	8	a	a	DT
cord-006229-7yoilsho	249	9	method	method	NN
cord-006229-7yoilsho	249	10	for	for	IN
cord-006229-7yoilsho	249	11	delivering	deliver	VBG
cord-006229-7yoilsho	249	12	siRNAs	siRNAs	NNP
cord-006229-7yoilsho	249	13	in	in	IN
cord-006229-7yoilsho	249	14	polymeric	polymeric	JJ
cord-006229-7yoilsho	249	15	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	249	16	based	base	VBN
cord-006229-7yoilsho	249	17	on	on	IN
cord-006229-7yoilsho	249	18	low	low	JJ
cord-006229-7yoilsho	249	19	molecular	molecular	JJ
cord-006229-7yoilsho	249	20	weight	weight	NN
cord-006229-7yoilsho	249	21	polyethylenimines	polyethylenimine	NNS
cord-006229-7yoilsho	249	22	(	(	-LRB-
cord-006229-7yoilsho	249	23	PEIs	PEIs	NNPS
cord-006229-7yoilsho	249	24	)	)	-RRB-
cord-006229-7yoilsho	249	25	.	.	.
cord-006229-7yoilsho	250	1	Their	-PRON-	PRP$
cord-006229-7yoilsho	250	2	intracerebroventricular	intracerebroventricular	NN
cord-006229-7yoilsho	250	3	(	(	-LRB-
cord-006229-7yoilsho	250	4	ICV	ICV	NNP
cord-006229-7yoilsho	250	5	)	)	-RRB-
cord-006229-7yoilsho	250	6	injection	injection	NN
cord-006229-7yoilsho	250	7	leads	lead	VBZ
cord-006229-7yoilsho	250	8	to	to	IN
cord-006229-7yoilsho	250	9	in	in	IN
cord-006229-7yoilsho	250	10	vivo	vivo	NN
cord-006229-7yoilsho	250	11	silencing	silencing	NN
cord-006229-7yoilsho	250	12	of	of	IN
cord-006229-7yoilsho	250	13	neuronal	neuronal	JJ
cord-006229-7yoilsho	250	14	gene	gene	NN
cord-006229-7yoilsho	250	15	expression	expression	NN
cord-006229-7yoilsho	250	16	in	in	IN
cord-006229-7yoilsho	250	17	the	the	DT
cord-006229-7yoilsho	250	18	brain	brain	NN
cord-006229-7yoilsho	250	19	of	of	IN
cord-006229-7yoilsho	250	20	mice	mouse	NNS
cord-006229-7yoilsho	250	21	overexpressing	overexpressing	NNP
cord-006229-7yoilsho	250	22	α	α	NNP
cord-006229-7yoilsho	250	23	-	-	HYPH
cord-006229-7yoilsho	250	24	synuclein	synuclein	NNP
cord-006229-7yoilsho	250	25	(	(	-LRB-
cord-006229-7yoilsho	250	26	Thy1-aSyn	thy1-asyn	JJ
cord-006229-7yoilsho	250	27	mice	mouse	NNS
cord-006229-7yoilsho	250	28	)	)	-RRB-
cord-006229-7yoilsho	250	29	.	.	.
cord-006229-7yoilsho	251	1	In	in	IN
cord-006229-7yoilsho	251	2	a	a	DT
cord-006229-7yoilsho	251	3	first	first	JJ
cord-006229-7yoilsho	251	4	step	step	NN
cord-006229-7yoilsho	251	5	,	,	,
cord-006229-7yoilsho	251	6	PEI	PEI	NNP
cord-006229-7yoilsho	251	7	-	-	HYPH
cord-006229-7yoilsho	251	8	complexed	complexed	NNP
cord-006229-7yoilsho	251	9	siRNA	siRNA	NNP
cord-006229-7yoilsho	251	10	tagged	tag	VBN
cord-006229-7yoilsho	251	11	with	with	IN
cord-006229-7yoilsho	251	12	afluorescencedye	afluorescencedye	NNP
cord-006229-7yoilsho	251	13	were	be	VBD
cord-006229-7yoilsho	251	14	injected	inject	VBN
cord-006229-7yoilsho	251	15	to	to	TO
cord-006229-7yoilsho	251	16	track	track	VB
cord-006229-7yoilsho	251	17	the	the	DT
cord-006229-7yoilsho	251	18	localization	localization	NN
cord-006229-7yoilsho	251	19	and	and	CC
cord-006229-7yoilsho	251	20	distribution	distribution	NN
cord-006229-7yoilsho	251	21	after	after	IN
cord-006229-7yoilsho	251	22	ICV	ICV	NNP
cord-006229-7yoilsho	251	23	administration	administration	NN
cord-006229-7yoilsho	251	24	.	.	.
cord-006229-7yoilsho	252	1	Five	five	CD
cord-006229-7yoilsho	252	2	days	day	NNS
cord-006229-7yoilsho	252	3	later	later	RB
cord-006229-7yoilsho	252	4	,	,	,
cord-006229-7yoilsho	252	5	fluorescent	fluorescent	NN
cord-006229-7yoilsho	252	6	cells	cell	NNS
cord-006229-7yoilsho	252	7	were	be	VBD
cord-006229-7yoilsho	252	8	visible	visible	JJ
cord-006229-7yoilsho	252	9	throughout	throughout	IN
cord-006229-7yoilsho	252	10	the	the	DT
cord-006229-7yoilsho	252	11	brain	brain	NN
cord-006229-7yoilsho	252	12	,	,	,
cord-006229-7yoilsho	252	13	with	with	IN
cord-006229-7yoilsho	252	14	the	the	DT
cord-006229-7yoilsho	252	15	highest	high	JJS
cord-006229-7yoilsho	252	16	fluorescence	fluorescence	NN
cord-006229-7yoilsho	252	17	intensity	intensity	NN
cord-006229-7yoilsho	252	18	around	around	IN
cord-006229-7yoilsho	252	19	the	the	DT
cord-006229-7yoilsho	252	20	ventricles	ventricle	NNS
cord-006229-7yoilsho	252	21	.	.	.
cord-006229-7yoilsho	253	1	Fluorescence	fluorescence	NN
cord-006229-7yoilsho	253	2	was	be	VBD
cord-006229-7yoilsho	253	3	also	also	RB
cord-006229-7yoilsho	253	4	observed	observe	VBN
cord-006229-7yoilsho	253	5	in	in	IN
cord-006229-7yoilsho	253	6	large	large	JJ
cord-006229-7yoilsho	253	7	cells	cell	NNS
cord-006229-7yoilsho	253	8	of	of	IN
cord-006229-7yoilsho	253	9	the	the	DT
cord-006229-7yoilsho	253	10	lumbar	lumbar	JJ
cord-006229-7yoilsho	253	11	spinal	spinal	JJ
cord-006229-7yoilsho	253	12	cord	cord	NN
cord-006229-7yoilsho	253	13	.	.	.
cord-006229-7yoilsho	254	1	Moreover	moreover	RB
cord-006229-7yoilsho	254	2	,	,	,
cord-006229-7yoilsho	254	3	preliminaryresultsdemonstrate	preliminaryresultsdemonstrate	VBP
cord-006229-7yoilsho	254	4	a	a	DT
cord-006229-7yoilsho	254	5	42.6	42.6	CD
cord-006229-7yoilsho	254	6	%	%	NN
cord-006229-7yoilsho	254	7	knockdown	knockdown	NN
cord-006229-7yoilsho	254	8	(	(	-LRB-
cord-006229-7yoilsho	254	9	p<0.05	p<0.05	CD
cord-006229-7yoilsho	254	10	student	student	NN
cord-006229-7yoilsho	254	11	's	's	POS
cord-006229-7yoilsho	254	12	t	t	NN
cord-006229-7yoilsho	254	13	-	-	HYPH
cord-006229-7yoilsho	254	14	test	test	NN
cord-006229-7yoilsho	254	15	,	,	,
cord-006229-7yoilsho	254	16	n=6	n=6	JJ
cord-006229-7yoilsho	254	17	)	)	-RRB-
cord-006229-7yoilsho	254	18	of	of	IN
cord-006229-7yoilsho	254	19	human	human	JJ
cord-006229-7yoilsho	254	20	α	α	NNP
cord-006229-7yoilsho	254	21	-	-	HYPH
cord-006229-7yoilsho	254	22	synuclein	synuclein	NNP
cord-006229-7yoilsho	254	23	(	(	-LRB-
cord-006229-7yoilsho	254	24	SNCA	SNCA	NNP
cord-006229-7yoilsho	254	25	)	)	-RRB-
cord-006229-7yoilsho	254	26	in	in	IN
cord-006229-7yoilsho	254	27	thetargetstructurestriatum	thetargetstructurestriatum	XX
cord-006229-7yoilsho	254	28	upon	upon	IN
cord-006229-7yoilsho	254	29	a	a	DT
cord-006229-7yoilsho	254	30	single	single	JJ
cord-006229-7yoilsho	254	31	ICV	ICV	NNP
cord-006229-7yoilsho	254	32	injection	injection	NN
cord-006229-7yoilsho	254	33	of	of	IN
cord-006229-7yoilsho	254	34	PEI	PEI	NNP
cord-006229-7yoilsho	254	35	-	-	HYPH
cord-006229-7yoilsho	254	36	complexed	complexe	VBN
cord-006229-7yoilsho	254	37	specific	specific	JJ
cord-006229-7yoilsho	254	38	siRNA	siRNA	NNS
cord-006229-7yoilsho	254	39	compared	compare	VBN
cord-006229-7yoilsho	254	40	to	to	IN
cord-006229-7yoilsho	254	41	the	the	DT
cord-006229-7yoilsho	254	42	control	control	NN
cord-006229-7yoilsho	254	43	injection	injection	NN
cord-006229-7yoilsho	254	44	group	group	NN
cord-006229-7yoilsho	254	45	(	(	-LRB-
cord-006229-7yoilsho	254	46	n=9	n=9	NN
cord-006229-7yoilsho	254	47	)	)	-RRB-
cord-006229-7yoilsho	254	48	.	.	.
cord-006229-7yoilsho	255	1	Hence	hence	RB
cord-006229-7yoilsho	255	2	,	,	,
cord-006229-7yoilsho	255	3	our	-PRON-	PRP$
cord-006229-7yoilsho	255	4	first	first	JJ
cord-006229-7yoilsho	255	5	results	result	NNS
cord-006229-7yoilsho	255	6	support	support	VBP
cord-006229-7yoilsho	255	7	the	the	DT
cord-006229-7yoilsho	255	8	usability	usability	NN
cord-006229-7yoilsho	255	9	and	and	CC
cord-006229-7yoilsho	255	10	efficacy	efficacy	NN
cord-006229-7yoilsho	255	11	of	of	IN
cord-006229-7yoilsho	255	12	PEI	PEI	NNP
cord-006229-7yoilsho	255	13	nanoparticle	nanoparticle	NN
cord-006229-7yoilsho	255	14	-	-	HYPH
cord-006229-7yoilsho	255	15	mediated	mediate	VBN
cord-006229-7yoilsho	255	16	delivery	delivery	NN
cord-006229-7yoilsho	255	17	of	of	IN
cord-006229-7yoilsho	255	18	short	short	JJ
cord-006229-7yoilsho	255	19	RNAs	rna	NNS
cord-006229-7yoilsho	255	20	,	,	,
cord-006229-7yoilsho	255	21	namely	namely	RB
cord-006229-7yoilsho	255	22	siRNAs	siRNAs	NNP
cord-006229-7yoilsho	255	23	,	,	,
cord-006229-7yoilsho	255	24	for	for	IN
cord-006229-7yoilsho	255	25	rapidly	rapidly	RB
cord-006229-7yoilsho	255	26	and	and	CC
cord-006229-7yoilsho	255	27	efficiently	efficiently	RB
cord-006229-7yoilsho	255	28	reducing	reduce	VBG
cord-006229-7yoilsho	255	29	the	the	DT
cord-006229-7yoilsho	255	30	expression	expression	NN
cord-006229-7yoilsho	255	31	of	of	IN
cord-006229-7yoilsho	255	32	a	a	DT
cord-006229-7yoilsho	255	33	neuronal	neuronal	JJ
cord-006229-7yoilsho	255	34	target	target	NN
cord-006229-7yoilsho	255	35	gene	gene	NN
cord-006229-7yoilsho	255	36	of	of	IN
cord-006229-7yoilsho	255	37	interest	interest	NN
cord-006229-7yoilsho	255	38	in	in	IN
cord-006229-7yoilsho	255	39	the	the	DT
cord-006229-7yoilsho	255	40	brain	brain	NN
cord-006229-7yoilsho	255	41	in	in	IN
cord-006229-7yoilsho	255	42	vivo	vivo	NNP
cord-006229-7yoilsho	255	43	.	.	.
cord-006229-7yoilsho	256	1	This	this	DT
cord-006229-7yoilsho	256	2	may	may	MD
cord-006229-7yoilsho	256	3	allow	allow	VB
cord-006229-7yoilsho	256	4	the	the	DT
cord-006229-7yoilsho	256	5	development	development	NN
cord-006229-7yoilsho	256	6	of	of	IN
cord-006229-7yoilsho	256	7	gene	gene	NN
cord-006229-7yoilsho	256	8	therapy	therapy	NN
cord-006229-7yoilsho	256	9	strategies	strategy	NNS
cord-006229-7yoilsho	256	10	for	for	IN
cord-006229-7yoilsho	256	11	the	the	DT
cord-006229-7yoilsho	256	12	treatment	treatment	NN
cord-006229-7yoilsho	256	13	of	of	IN
cord-006229-7yoilsho	256	14	neurodegenerative	neurodegenerative	JJ
cord-006229-7yoilsho	256	15	diseases	disease	NNS
cord-006229-7yoilsho	256	16	.	.	.
cord-006229-7yoilsho	257	1	is	be	VBZ
cord-006229-7yoilsho	257	2	a	a	DT
cord-006229-7yoilsho	257	3	propenylic	propenylic	NN
cord-006229-7yoilsho	257	4	alkenylbenzene	alkenylbenzene	NN
cord-006229-7yoilsho	257	5	found	find	VBN
cord-006229-7yoilsho	257	6	in	in	IN
cord-006229-7yoilsho	257	7	several	several	JJ
cord-006229-7yoilsho	257	8	plants	plant	NNS
cord-006229-7yoilsho	257	9	,	,	,
cord-006229-7yoilsho	257	10	e.g.	e.g.	RB
cord-006229-7yoilsho	257	11	Acorus	Acorus	NNP
cord-006229-7yoilsho	257	12	calamus	calamus	NN
cord-006229-7yoilsho	257	13	.	.	.
cord-006229-7yoilsho	258	1	bAcontaining	bacontaine	VBG
cord-006229-7yoilsho	258	2	plant	plant	NN
cord-006229-7yoilsho	258	3	materials	material	NNS
cord-006229-7yoilsho	258	4	are	be	VBP
cord-006229-7yoilsho	258	5	used	use	VBN
cord-006229-7yoilsho	258	6	to	to	TO
cord-006229-7yoilsho	258	7	flavor	flavor	VB
cord-006229-7yoilsho	258	8	foods	food	NNS
cord-006229-7yoilsho	258	9	,	,	,
cord-006229-7yoilsho	258	10	and	and	CC
cord-006229-7yoilsho	258	11	are	be	VBP
cord-006229-7yoilsho	258	12	active	active	JJ
cord-006229-7yoilsho	258	13	ingredients	ingredient	NNS
cord-006229-7yoilsho	258	14	in	in	IN
cord-006229-7yoilsho	258	15	traditional	traditional	JJ
cord-006229-7yoilsho	258	16	plant	plant	NN
cord-006229-7yoilsho	258	17	medicines	medicine	NNS
cord-006229-7yoilsho	258	18	.	.	.
cord-006229-7yoilsho	259	1	Thus	thus	RB
cord-006229-7yoilsho	259	2	,	,	,
cord-006229-7yoilsho	259	3	human	human	JJ
cord-006229-7yoilsho	259	4	exposure	exposure	NN
cord-006229-7yoilsho	259	5	results	result	NNS
cord-006229-7yoilsho	259	6	primarily	primarily	RB
cord-006229-7yoilsho	259	7	from	from	IN
cord-006229-7yoilsho	259	8	the	the	DT
cord-006229-7yoilsho	259	9	intake	intake	NN
cord-006229-7yoilsho	259	10	of	of	IN
cord-006229-7yoilsho	259	11	bitters	bitter	NNS
cord-006229-7yoilsho	259	12	and	and	CC
cord-006229-7yoilsho	259	13	teas	tea	NNS
cord-006229-7yoilsho	259	14	,	,	,
cord-006229-7yoilsho	259	15	as	as	RB
cord-006229-7yoilsho	259	16	well	well	RB
cord-006229-7yoilsho	259	17	as	as	IN
cord-006229-7yoilsho	259	18	from	from	IN
cord-006229-7yoilsho	259	19	Calamus	Calamus	NNP
cord-006229-7yoilsho	259	20	-	-	HYPH
cord-006229-7yoilsho	259	21	containing	contain	VBG
cord-006229-7yoilsho	259	22	medicines	medicine	NNS
cord-006229-7yoilsho	259	23	and	and	CC
cord-006229-7yoilsho	259	24	plant	plant	NN
cord-006229-7yoilsho	259	25	food	food	NN
cord-006229-7yoilsho	259	26	supplements	supplement	NNS
cord-006229-7yoilsho	259	27	.	.	.
cord-006229-7yoilsho	260	1	Although	although	IN
cord-006229-7yoilsho	260	2	many	many	JJ
cord-006229-7yoilsho	260	3	(	(	-LRB-
cord-006229-7yoilsho	260	4	positive	positive	JJ
cord-006229-7yoilsho	260	5	)	)	-RRB-
cord-006229-7yoilsho	260	6	pharmacological	pharmacological	JJ
cord-006229-7yoilsho	260	7	properties	property	NNS
cord-006229-7yoilsho	260	8	/	/	SYM
cord-006229-7yoilsho	260	9	effects	effect	NNS
cord-006229-7yoilsho	260	10	of	of	IN
cord-006229-7yoilsho	260	11	asarone	asarone	NN
cord-006229-7yoilsho	260	12	isomers	isomer	NNS
cord-006229-7yoilsho	260	13	are	be	VBP
cord-006229-7yoilsho	260	14	described	describe	VBN
cord-006229-7yoilsho	260	15	in	in	IN
cord-006229-7yoilsho	260	16	the	the	DT
cord-006229-7yoilsho	260	17	literature	literature	NN
cord-006229-7yoilsho	260	18	,	,	,
cord-006229-7yoilsho	260	19	bA	bA	NNP
cord-006229-7yoilsho	260	20	was	be	VBD
cord-006229-7yoilsho	260	21	found	find	VBN
cord-006229-7yoilsho	260	22	to	to	TO
cord-006229-7yoilsho	260	23	be	be	VB
cord-006229-7yoilsho	260	24	carcinogenic	carcinogenic	JJ
cord-006229-7yoilsho	260	25	in	in	IN
cord-006229-7yoilsho	260	26	rodents	rodent	NNS
cord-006229-7yoilsho	260	27	(	(	-LRB-
cord-006229-7yoilsho	260	28	liver	liver	NN
cord-006229-7yoilsho	260	29	,	,	,
cord-006229-7yoilsho	260	30	duodenum	duodenum	NN
cord-006229-7yoilsho	260	31	)	)	-RRB-
cord-006229-7yoilsho	260	32	when	when	WRB
cord-006229-7yoilsho	260	33	given	give	VBN
cord-006229-7yoilsho	260	34	daily	daily	RB
cord-006229-7yoilsho	260	35	or	or	CC
cord-006229-7yoilsho	260	36	in	in	IN
cord-006229-7yoilsho	260	37	a	a	DT
cord-006229-7yoilsho	260	38	single	single	JJ
cord-006229-7yoilsho	260	39	dosage	dosage	NN
cord-006229-7yoilsho	260	40	.	.	.
cord-006229-7yoilsho	261	1	Early	early	JJ
cord-006229-7yoilsho	261	2	experiments	experiment	NNS
cord-006229-7yoilsho	261	3	indicated	indicate	VBD
cord-006229-7yoilsho	261	4	that	that	IN
cord-006229-7yoilsho	261	5	bA	bA	NNP
cord-006229-7yoilsho	261	6	is	be	VBZ
cord-006229-7yoilsho	261	7	not	not	RB
cord-006229-7yoilsho	261	8	activated	activate	VBN
cord-006229-7yoilsho	261	9	via	via	IN
cord-006229-7yoilsho	261	10	hydroxylation	hydroxylation	NN
cord-006229-7yoilsho	261	11	and	and	CC
cord-006229-7yoilsho	261	12	sulfonation	sulfonation	NN
cord-006229-7yoilsho	261	13	as	as	IN
cord-006229-7yoilsho	261	14	it	-PRON-	PRP
cord-006229-7yoilsho	261	15	is	be	VBZ
cord-006229-7yoilsho	261	16	the	the	DT
cord-006229-7yoilsho	261	17	case	case	NN
cord-006229-7yoilsho	261	18	for	for	IN
cord-006229-7yoilsho	261	19	known	know	VBN
cord-006229-7yoilsho	261	20	hepatocarcinogenic	hepatocarcinogenic	NNP
cord-006229-7yoilsho	261	21	allylic	allylic	NNP
cord-006229-7yoilsho	261	22	alkenylbenzenes	alkenylbenzene	NNS
cord-006229-7yoilsho	261	23	such	such	JJ
cord-006229-7yoilsho	261	24	as	as	IN
cord-006229-7yoilsho	261	25	estragole	estragole	NNP
cord-006229-7yoilsho	261	26	or	or	CC
cord-006229-7yoilsho	261	27	methyleugenol	methyleugenol	NNP
cord-006229-7yoilsho	261	28	.	.	.
cord-006229-7yoilsho	262	1	Because	because	IN
cord-006229-7yoilsho	262	2	the	the	DT
cord-006229-7yoilsho	262	3	mechanism	mechanism	NN
cord-006229-7yoilsho	262	4	of	of	IN
cord-006229-7yoilsho	262	5	metabolic	metabolic	JJ
cord-006229-7yoilsho	262	6	activation	activation	NN
cord-006229-7yoilsho	262	7	of	of	IN
cord-006229-7yoilsho	262	8	bA	bA	NNP
cord-006229-7yoilsho	262	9	in	in	IN
cord-006229-7yoilsho	262	10	not	not	RB
cord-006229-7yoilsho	262	11	known	know	VBN
cord-006229-7yoilsho	262	12	,	,	,
cord-006229-7yoilsho	262	13	we	-PRON-	PRP
cord-006229-7yoilsho	262	14	investigated	investigate	VBD
cord-006229-7yoilsho	262	15	the	the	DT
cord-006229-7yoilsho	262	16	metabolism	metabolism	NN
cord-006229-7yoilsho	262	17	of	of	IN
cord-006229-7yoilsho	262	18	bA	bA	NNP
cord-006229-7yoilsho	262	19	in	in	IN
cord-006229-7yoilsho	262	20	liver	liver	NN
cord-006229-7yoilsho	262	21	microsomes	microsome	NNS
cord-006229-7yoilsho	262	22	and	and	CC
cord-006229-7yoilsho	262	23	human	human	JJ
cord-006229-7yoilsho	262	24	cytochrome	cytochrome	NN
cord-006229-7yoilsho	262	25	P450	P450	NNPS
cord-006229-7yoilsho	262	26	(	(	-LRB-
cord-006229-7yoilsho	262	27	CYP	CYP	NNP
cord-006229-7yoilsho	262	28	)	)	-RRB-
cord-006229-7yoilsho	262	29	enzymes	enzyme	NNS
cord-006229-7yoilsho	262	30	,	,	,
cord-006229-7yoilsho	262	31	the	the	DT
cord-006229-7yoilsho	262	32	mutagenicity	mutagenicity	NN
cord-006229-7yoilsho	262	33	of	of	IN
cord-006229-7yoilsho	262	34	bA	bA	NNP
cord-006229-7yoilsho	262	35	and	and	CC
cord-006229-7yoilsho	262	36	its	-PRON-	PRP$
cord-006229-7yoilsho	262	37	metabolites	metabolite	NNS
cord-006229-7yoilsho	262	38	in	in	IN
cord-006229-7yoilsho	262	39	the	the	DT
cord-006229-7yoilsho	262	40	Ames	Ames	NNP
cord-006229-7yoilsho	262	41	fluctuation	fluctuation	NN
cord-006229-7yoilsho	262	42	assay	assay	NN
cord-006229-7yoilsho	262	43	and	and	CC
cord-006229-7yoilsho	262	44	the	the	DT
cord-006229-7yoilsho	262	45	DNA	dna	NN
cord-006229-7yoilsho	262	46	adduct	adduct	NN
cord-006229-7yoilsho	262	47	formation	formation	NN
cord-006229-7yoilsho	262	48	in	in	IN
cord-006229-7yoilsho	262	49	primary	primary	JJ
cord-006229-7yoilsho	262	50	rat	rat	NN
cord-006229-7yoilsho	262	51	hepatocytes	hepatocyte	NNS
cord-006229-7yoilsho	262	52	.	.	.
cord-006229-7yoilsho	263	1	We	-PRON-	PRP
cord-006229-7yoilsho	263	2	found	find	VBD
cord-006229-7yoilsho	263	3	that	that	IN
cord-006229-7yoilsho	263	4	side	side	NN
cord-006229-7yoilsho	263	5	-	-	HYPH
cord-006229-7yoilsho	263	6	chain	chain	NN
cord-006229-7yoilsho	263	7	epoxidation	epoxidation	NN
cord-006229-7yoilsho	263	8	(	(	-LRB-
cord-006229-7yoilsho	263	9	leading	lead	VBG
cord-006229-7yoilsho	263	10	to	to	IN
cord-006229-7yoilsho	263	11	diols	diol	NNS
cord-006229-7yoilsho	263	12	and	and	CC
cord-006229-7yoilsho	263	13	a	a	DT
cord-006229-7yoilsho	263	14	ketone	ketone	NN
cord-006229-7yoilsho	263	15	)	)	-RRB-
cord-006229-7yoilsho	263	16	was	be	VBD
cord-006229-7yoilsho	263	17	by	by	IN
cord-006229-7yoilsho	263	18	far	far	RB
cord-006229-7yoilsho	263	19	the	the	DT
cord-006229-7yoilsho	263	20	most	most	RBS
cord-006229-7yoilsho	263	21	dominating	dominating	JJ
cord-006229-7yoilsho	263	22	metabolic	metabolic	JJ
cord-006229-7yoilsho	263	23	route	route	NN
cord-006229-7yoilsho	263	24	of	of	IN
cord-006229-7yoilsho	263	25	bA	bA	NNP
cord-006229-7yoilsho	263	26	in	in	IN
cord-006229-7yoilsho	263	27	liver	liver	NN
cord-006229-7yoilsho	263	28	microsomes	microsome	NNS
cord-006229-7yoilsho	263	29	and	and	CC
cord-006229-7yoilsho	263	30	human	human	JJ
cord-006229-7yoilsho	263	31	CYP	CYP	NNP
cord-006229-7yoilsho	263	32	enzymes	enzyme	NNS
cord-006229-7yoilsho	263	33	.	.	.
cord-006229-7yoilsho	264	1	bA	bA	NNP
cord-006229-7yoilsho	264	2	was	be	VBD
cord-006229-7yoilsho	264	3	mutagenic	mutagenic	JJ
cord-006229-7yoilsho	264	4	in	in	IN
cord-006229-7yoilsho	264	5	the	the	DT
cord-006229-7yoilsho	264	6	Ames	Ames	NNP
cord-006229-7yoilsho	264	7	test	test	NN
cord-006229-7yoilsho	264	8	(	(	-LRB-
cord-006229-7yoilsho	264	9	+	+	CC
cord-006229-7yoilsho	264	10	S9	S9	NNP
cord-006229-7yoilsho	264	11	mix	mix	NN
cord-006229-7yoilsho	264	12	)	)	-RRB-
cord-006229-7yoilsho	264	13	,	,	,
cord-006229-7yoilsho	264	14	as	as	IN
cord-006229-7yoilsho	264	15	was	be	VBD
cord-006229-7yoilsho	264	16	the	the	DT
cord-006229-7yoilsho	264	17	synthesized	synthesize	VBN
cord-006229-7yoilsho	264	18	bA	ba	NN
cord-006229-7yoilsho	264	19	-	-	HYPH
cord-006229-7yoilsho	264	20	epoxide	epoxide	NN
cord-006229-7yoilsho	264	21	(	(	-LRB-
cord-006229-7yoilsho	264	22	-S9	-S9	:
cord-006229-7yoilsho	264	23	mix	mix	NN
cord-006229-7yoilsho	264	24	)	)	-RRB-
cord-006229-7yoilsho	264	25	.	.	.
cord-006229-7yoilsho	265	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	265	2	,	,	,
cord-006229-7yoilsho	265	3	we	-PRON-	PRP
cord-006229-7yoilsho	265	4	were	be	VBD
cord-006229-7yoilsho	265	5	able	able	JJ
cord-006229-7yoilsho	265	6	to	to	TO
cord-006229-7yoilsho	265	7	synthesize	synthesize	VB
cord-006229-7yoilsho	265	8	and	and	CC
cord-006229-7yoilsho	265	9	characterize	characterize	VB
cord-006229-7yoilsho	265	10	a	a	DT
cord-006229-7yoilsho	265	11	bA	bA	NNP
cord-006229-7yoilsho	265	12	epoxide	epoxide	NN
cord-006229-7yoilsho	265	13	-	-	HYPH
cord-006229-7yoilsho	265	14	derived	derive	VBN
cord-006229-7yoilsho	265	15	DNA	dna	NN
cord-006229-7yoilsho	265	16	adduct	adduct	NN
cord-006229-7yoilsho	265	17	with	with	IN
cord-006229-7yoilsho	265	18	deoxyguanosine	deoxyguanosine	NNP
cord-006229-7yoilsho	265	19	.	.	.
cord-006229-7yoilsho	266	1	This	this	DT
cord-006229-7yoilsho	266	2	DNA	dna	NN
cord-006229-7yoilsho	266	3	adduct	adduct	NN
cord-006229-7yoilsho	266	4	was	be	VBD
cord-006229-7yoilsho	266	5	formed	form	VBN
cord-006229-7yoilsho	266	6	in	in	IN
cord-006229-7yoilsho	266	7	a	a	DT
cord-006229-7yoilsho	266	8	concentration	concentration	NN
cord-006229-7yoilsho	266	9	-	-	HYPH
cord-006229-7yoilsho	266	10	dependent	dependent	JJ
cord-006229-7yoilsho	266	11	manner	manner	NN
cord-006229-7yoilsho	266	12	in	in	IN
cord-006229-7yoilsho	266	13	rat	rat	NN
cord-006229-7yoilsho	266	14	hepatocytes	hepatocyte	NNS
cord-006229-7yoilsho	266	15	incubated	incubate	VBN
cord-006229-7yoilsho	266	16	with	with	IN
cord-006229-7yoilsho	266	17	bA.	bA.	NNS
cord-006229-7yoilsho	267	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	267	2	results	result	NNS
cord-006229-7yoilsho	267	3	strongly	strongly	RB
cord-006229-7yoilsho	267	4	indicate	indicate	VBP
cord-006229-7yoilsho	267	5	that	that	IN
cord-006229-7yoilsho	267	6	bA	bA	NNP
cord-006229-7yoilsho	267	7	is	be	VBZ
cord-006229-7yoilsho	267	8	genotoxic	genotoxic	JJ
cord-006229-7yoilsho	267	9	with	with	IN
cord-006229-7yoilsho	267	10	the	the	DT
cord-006229-7yoilsho	267	11	side	side	NN
cord-006229-7yoilsho	267	12	-	-	HYPH
cord-006229-7yoilsho	267	13	chain	chain	NN
cord-006229-7yoilsho	267	14	epoxide	epoxide	NN
cord-006229-7yoilsho	267	15	being	be	VBG
cord-006229-7yoilsho	267	16	its	-PRON-	PRP$
cord-006229-7yoilsho	267	17	ultimate	ultimate	JJ
cord-006229-7yoilsho	267	18	carcinogen	carcinogen	NN
cord-006229-7yoilsho	267	19	.	.	.
cord-006229-7yoilsho	268	1	Morbid	morbid	JJ
cord-006229-7yoilsho	268	2	Obesity	obesity	NN
cord-006229-7yoilsho	268	3	is	be	VBZ
cord-006229-7yoilsho	268	4	an	an	DT
cord-006229-7yoilsho	268	5	independent	independent	JJ
cord-006229-7yoilsho	268	6	risk	risk	NN
cord-006229-7yoilsho	268	7	factor	factor	NN
cord-006229-7yoilsho	268	8	for	for	IN
cord-006229-7yoilsho	268	9	cardiovascular	cardiovascular	JJ
cord-006229-7yoilsho	268	10	disease	disease	NN
cord-006229-7yoilsho	268	11	,	,	,
cord-006229-7yoilsho	268	12	Type	type	NN
cord-006229-7yoilsho	268	13	2	2	CD
cord-006229-7yoilsho	268	14	Diabetes	diabetes	NN
cord-006229-7yoilsho	268	15	mellitus	mellitus	NN
cord-006229-7yoilsho	268	16	and	and	CC
cord-006229-7yoilsho	268	17	certain	certain	JJ
cord-006229-7yoilsho	268	18	types	type	NNS
cord-006229-7yoilsho	268	19	of	of	IN
cord-006229-7yoilsho	268	20	cancer	cancer	NN
cord-006229-7yoilsho	268	21	.	.	.
cord-006229-7yoilsho	269	1	Bariatric	bariatric	NN
cord-006229-7yoilsho	269	2	surgery	surgery	NN
cord-006229-7yoilsho	270	1	-with	-with	.
cord-006229-7yoilsho	271	1	the	the	DT
cord-006229-7yoilsho	271	2	Roux	Roux	NNP
cord-006229-7yoilsho	271	3	-	-	HYPH
cord-006229-7yoilsho	271	4	en	en	NNP
cord-006229-7yoilsho	271	5	-	-	HYPH
cord-006229-7yoilsho	271	6	Y	Y	NNP
cord-006229-7yoilsho	271	7	gastric	gastric	JJ
cord-006229-7yoilsho	271	8	bypass	bypass	NN
cord-006229-7yoilsho	271	9	(	(	-LRB-
cord-006229-7yoilsho	271	10	RYGB	RYGB	NNP
cord-006229-7yoilsho	271	11	)	)	-RRB-
cord-006229-7yoilsho	271	12	being	be	VBG
cord-006229-7yoilsho	271	13	the	the	DT
cord-006229-7yoilsho	271	14	gold	gold	NN
cord-006229-7yoilsho	271	15	standard	standard	NN
cord-006229-7yoilsho	271	16	-has	-has	:
cord-006229-7yoilsho	271	17	become	become	VBN
cord-006229-7yoilsho	271	18	the	the	DT
cord-006229-7yoilsho	271	19	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	271	20	option	option	NN
cord-006229-7yoilsho	271	21	of	of	IN
cord-006229-7yoilsho	271	22	choice	choice	NN
cord-006229-7yoilsho	271	23	as	as	IN
cord-006229-7yoilsho	271	24	a	a	DT
cord-006229-7yoilsho	271	25	sustained	sustained	JJ
cord-006229-7yoilsho	271	26	weight	weight	NN
cord-006229-7yoilsho	271	27	loss	loss	NN
cord-006229-7yoilsho	271	28	and	and	CC
cord-006229-7yoilsho	271	29	improvement	improvement	NN
cord-006229-7yoilsho	271	30	of	of	IN
cord-006229-7yoilsho	271	31	associated	associated	JJ
cord-006229-7yoilsho	271	32	morbidity	morbidity	NN
cord-006229-7yoilsho	271	33	is	be	VBZ
cord-006229-7yoilsho	271	34	achieved	achieve	VBN
cord-006229-7yoilsho	271	35	in	in	IN
cord-006229-7yoilsho	271	36	the	the	DT
cord-006229-7yoilsho	271	37	majority	majority	NN
cord-006229-7yoilsho	271	38	of	of	IN
cord-006229-7yoilsho	271	39	patients	patient	NNS
cord-006229-7yoilsho	271	40	.	.	.
cord-006229-7yoilsho	272	1	There	there	EX
cord-006229-7yoilsho	272	2	is	be	VBZ
cord-006229-7yoilsho	272	3	,	,	,
cord-006229-7yoilsho	272	4	however	however	RB
cord-006229-7yoilsho	272	5	,	,	,
cord-006229-7yoilsho	272	6	a	a	DT
cord-006229-7yoilsho	272	7	lack	lack	NN
cord-006229-7yoilsho	272	8	of	of	IN
cord-006229-7yoilsho	272	9	evidence	evidence	NN
cord-006229-7yoilsho	272	10	focusing	focus	VBG
cord-006229-7yoilsho	272	11	on	on	IN
cord-006229-7yoilsho	272	12	bariatric	bariatric	JJ
cord-006229-7yoilsho	272	13	surgery	surgery	NN
cord-006229-7yoilsho	272	14	induced	induce	VBN
cord-006229-7yoilsho	272	15	sustained	sustain	VBD
cord-006229-7yoilsho	272	16	weight	weight	NN
cord-006229-7yoilsho	272	17	loss	loss	NN
cord-006229-7yoilsho	272	18	and	and	CC
cord-006229-7yoilsho	272	19	its	-PRON-	PRP$
cord-006229-7yoilsho	272	20	possible	possible	JJ
cord-006229-7yoilsho	272	21	impact	impact	NN
cord-006229-7yoilsho	272	22	on	on	IN
cord-006229-7yoilsho	272	23	cancer	cancer	NN
cord-006229-7yoilsho	272	24	risk	risk	NN
cord-006229-7yoilsho	272	25	.	.	.
cord-006229-7yoilsho	273	1	We	-PRON-	PRP
cord-006229-7yoilsho	273	2	investigated	investigate	VBD
cord-006229-7yoilsho	273	3	the	the	DT
cord-006229-7yoilsho	273	4	association	association	NN
cord-006229-7yoilsho	273	5	between	between	IN
cord-006229-7yoilsho	273	6	obesity	obesity	NN
cord-006229-7yoilsho	273	7	,	,	,
cord-006229-7yoilsho	273	8	oxidative	oxidative	JJ
cord-006229-7yoilsho	273	9	stress	stress	NN
cord-006229-7yoilsho	273	10	and	and	CC
cord-006229-7yoilsho	273	11	genomic	genomic	JJ
cord-006229-7yoilsho	273	12	damage	damage	NN
cord-006229-7yoilsho	273	13	after	after	IN
cord-006229-7yoilsho	273	14	Roux	roux	NN
cord-006229-7yoilsho	273	15	-	-	HYPH
cord-006229-7yoilsho	273	16	en	en	FW
cord-006229-7yoilsho	273	17	-	-	HYPH
cord-006229-7yoilsho	273	18	Y	Y	NNP
cord-006229-7yoilsho	273	19	gastric	gastric	JJ
cord-006229-7yoilsho	273	20	bypass	bypass	NN
cord-006229-7yoilsho	273	21	surgery	surgery	NN
cord-006229-7yoilsho	273	22	(	(	-LRB-
cord-006229-7yoilsho	273	23	RYGB	RYGB	NNP
cord-006229-7yoilsho	273	24	)	)	-RRB-
cord-006229-7yoilsho	273	25	or	or	CC
cord-006229-7yoilsho	273	26	caloric	caloric	JJ
cord-006229-7yoilsho	273	27	restriction	restriction	NN
cord-006229-7yoilsho	273	28	induced	induce	VBN
cord-006229-7yoilsho	273	29	weight	weight	NN
cord-006229-7yoilsho	273	30	loss	loss	NN
cord-006229-7yoilsho	273	31	in	in	IN
cord-006229-7yoilsho	273	32	the	the	DT
cord-006229-7yoilsho	273	33	obese	obese	JJ
cord-006229-7yoilsho	273	34	Zucker	Zucker	NNP
cord-006229-7yoilsho	273	35	rat	rat	NN
cord-006229-7yoilsho	273	36	.	.	.
cord-006229-7yoilsho	274	1	Obese	obese	JJ
cord-006229-7yoilsho	274	2	male	male	NN
cord-006229-7yoilsho	274	3	Zucker	Zucker	NNP
cord-006229-7yoilsho	274	4	fa	fa	NN
cord-006229-7yoilsho	274	5	/	/	SYM
cord-006229-7yoilsho	274	6	fa	fa	NN
cord-006229-7yoilsho	274	7	rats	rat	NNS
cord-006229-7yoilsho	274	8	were	be	VBD
cord-006229-7yoilsho	274	9	divided	divide	VBN
cord-006229-7yoilsho	274	10	into	into	IN
cord-006229-7yoilsho	274	11	three	three	CD
cord-006229-7yoilsho	274	12	groups	group	NNS
cord-006229-7yoilsho	274	13	:	:	:
cord-006229-7yoilsho	274	14	sham	sham	NNP
cord-006229-7yoilsho	274	15	surgery	surgery	NN
cord-006229-7yoilsho	274	16	(	(	-LRB-
cord-006229-7yoilsho	274	17	sham	sham	NNP
cord-006229-7yoilsho	274	18	)	)	-RRB-
cord-006229-7yoilsho	274	19	,	,	,
cord-006229-7yoilsho	274	20	RYGB	RYGB	NNP
cord-006229-7yoilsho	274	21	and	and	CC
cord-006229-7yoilsho	274	22	caloric	caloric	JJ
cord-006229-7yoilsho	274	23	restriction	restriction	NN
cord-006229-7yoilsho	274	24	(	(	-LRB-
cord-006229-7yoilsho	274	25	CR	CR	NNP
cord-006229-7yoilsho	274	26	)	)	-RRB-
cord-006229-7yoilsho	274	27	and	and	CC
cord-006229-7yoilsho	274	28	were	be	VBD
cord-006229-7yoilsho	274	29	compared	compare	VBN
cord-006229-7yoilsho	274	30	with	with	IN
cord-006229-7yoilsho	274	31	lean	lean	JJ
cord-006229-7yoilsho	274	32	controls	control	NNS
cord-006229-7yoilsho	274	33	(	(	-LRB-
cord-006229-7yoilsho	274	34	Lean	Lean	NNP
cord-006229-7yoilsho	274	35	;	;	:
cord-006229-7yoilsho	274	36	Zucker	Zucker	NNP
cord-006229-7yoilsho	274	37	fa/+	fa/+	IN
cord-006229-7yoilsho	274	38	rats	rat	NNS
cord-006229-7yoilsho	274	39	)	)	-RRB-
cord-006229-7yoilsho	274	40	.	.	.
cord-006229-7yoilsho	275	1	Shams	sham	NNS
cord-006229-7yoilsho	275	2	showed	show	VBD
cord-006229-7yoilsho	275	3	impaired	impaired	JJ
cord-006229-7yoilsho	275	4	glucose	glucose	NN
cord-006229-7yoilsho	275	5	tolerance	tolerance	NN
cord-006229-7yoilsho	275	6	and	and	CC
cord-006229-7yoilsho	275	7	elevated	elevated	JJ
cord-006229-7yoilsho	275	8	plasma	plasma	NN
cord-006229-7yoilsho	275	9	insulin	insulin	NN
cord-006229-7yoilsho	275	10	levels	level	NNS
cord-006229-7yoilsho	275	11	,	,	,
cord-006229-7yoilsho	275	12	which	which	WDT
cord-006229-7yoilsho	275	13	were	be	VBD
cord-006229-7yoilsho	275	14	less	less	RBR
cord-006229-7yoilsho	275	15	severe	severe	JJ
cord-006229-7yoilsho	275	16	in	in	IN
cord-006229-7yoilsho	275	17	RYGB	RYGB	NNP
cord-006229-7yoilsho	275	18	and	and	CC
cord-006229-7yoilsho	275	19	CR	CR	NNP
cord-006229-7yoilsho	275	20	.	.	.
cord-006229-7yoilsho	276	1	Oxidative	oxidative	JJ
cord-006229-7yoilsho	276	2	stress	stress	NN
cord-006229-7yoilsho	276	3	was	be	VBD
cord-006229-7yoilsho	276	4	elevated	elevate	VBN
cord-006229-7yoilsho	276	5	in	in	IN
cord-006229-7yoilsho	276	6	kidney	kidney	NN
cord-006229-7yoilsho	276	7	,	,	,
cord-006229-7yoilsho	276	8	liver	liver	NN
cord-006229-7yoilsho	276	9	and	and	CC
cord-006229-7yoilsho	276	10	colon	colon	NN
cord-006229-7yoilsho	276	11	tissue	tissue	NN
cord-006229-7yoilsho	276	12	of	of	IN
cord-006229-7yoilsho	276	13	sham	sham	NN
cord-006229-7yoilsho	276	14	and	and	CC
cord-006229-7yoilsho	276	15	reduced	reduce	VBN
cord-006229-7yoilsho	276	16	again	again	RB
cord-006229-7yoilsho	276	17	after	after	IN
cord-006229-7yoilsho	276	18	weight	weight	NN
cord-006229-7yoilsho	276	19	loss	loss	NN
cord-006229-7yoilsho	276	20	induced	induce	VBN
cord-006229-7yoilsho	276	21	by	by	IN
cord-006229-7yoilsho	276	22	either	either	CC
cord-006229-7yoilsho	276	23	RYGB	RYGB	NNP
cord-006229-7yoilsho	276	24	or	or	CC
cord-006229-7yoilsho	276	25	BWM	BWM	NNP
cord-006229-7yoilsho	276	26	.	.	.
cord-006229-7yoilsho	277	1	Urine	urine	NN
cord-006229-7yoilsho	277	2	-	-	HYPH
cord-006229-7yoilsho	277	3	derived	derive	VBN
cord-006229-7yoilsho	277	4	oxidization	oxidization	NN
cord-006229-7yoilsho	277	5	products	product	NNS
cord-006229-7yoilsho	277	6	of	of	IN
cord-006229-7yoilsho	277	7	lipids	lipid	NNS
cord-006229-7yoilsho	277	8	,	,	,
cord-006229-7yoilsho	277	9	DNA	DNA	NNP
cord-006229-7yoilsho	277	10	and	and	CC
cord-006229-7yoilsho	277	11	RNA	RNA	NNP
cord-006229-7yoilsho	277	12	increased	increase	VBD
cord-006229-7yoilsho	277	13	in	in	IN
cord-006229-7yoilsho	277	14	Shams	Shams	NNP
cord-006229-7yoilsho	277	15	and	and	CC
cord-006229-7yoilsho	277	16	decreased	decrease	VBD
cord-006229-7yoilsho	277	17	after	after	IN
cord-006229-7yoilsho	277	18	weight	weight	NN
cord-006229-7yoilsho	277	19	loss	loss	NN
cord-006229-7yoilsho	277	20	(	(	-LRB-
cord-006229-7yoilsho	277	21	RYGB	RYGB	NNP
cord-006229-7yoilsho	277	22	and	and	CC
cord-006229-7yoilsho	277	23	CR	CR	NNP
cord-006229-7yoilsho	277	24	)	)	-RRB-
cord-006229-7yoilsho	277	25	.	.	.
cord-006229-7yoilsho	278	1	DNA	DNA	NNP
cord-006229-7yoilsho	278	2	double	double	JJ
cord-006229-7yoilsho	278	3	strand	strand	NN
cord-006229-7yoilsho	278	4	breaks	break	NNS
cord-006229-7yoilsho	278	5	were	be	VBD
cord-006229-7yoilsho	278	6	more	more	RBR
cord-006229-7yoilsho	278	7	frequent	frequent	JJ
cord-006229-7yoilsho	278	8	in	in	IN
cord-006229-7yoilsho	278	9	shams	sham	NNS
cord-006229-7yoilsho	278	10	than	than	IN
cord-006229-7yoilsho	278	11	in	in	IN
cord-006229-7yoilsho	278	12	the	the	DT
cord-006229-7yoilsho	278	13	weight	weight	NN
cord-006229-7yoilsho	278	14	loss	loss	NN
cord-006229-7yoilsho	278	15	groups	group	NNS
cord-006229-7yoilsho	278	16	or	or	CC
cord-006229-7yoilsho	278	17	lean	lean	JJ
cord-006229-7yoilsho	278	18	.	.	.
cord-006229-7yoilsho	279	1	DNA	dna	NN
cord-006229-7yoilsho	279	2	damage	damage	NN
cord-006229-7yoilsho	279	3	in	in	IN
cord-006229-7yoilsho	279	4	Zucker	Zucker	NNP
cord-006229-7yoilsho	279	5	fa	fa	NNP
cord-006229-7yoilsho	279	6	/	/	SYM
cord-006229-7yoilsho	279	7	fa	fa	IN
cord-006229-7yoilsho	279	8	rats	rat	NNS
cord-006229-7yoilsho	279	9	correlated	correlate	VBD
cord-006229-7yoilsho	279	10	with	with	IN
cord-006229-7yoilsho	279	11	their	-PRON-	PRP$
cord-006229-7yoilsho	279	12	basal	basal	NN
cord-006229-7yoilsho	279	13	plasma	plasma	NN
cord-006229-7yoilsho	279	14	insulin	insulin	NN
cord-006229-7yoilsho	279	15	values	value	NNS
cord-006229-7yoilsho	279	16	.	.	.
cord-006229-7yoilsho	280	1	Obese	obese	JJ
cord-006229-7yoilsho	280	2	rats	rat	NNS
cord-006229-7yoilsho	280	3	showed	show	VBD
cord-006229-7yoilsho	280	4	elevated	elevated	JJ
cord-006229-7yoilsho	280	5	oxidative	oxidative	JJ
cord-006229-7yoilsho	280	6	stress	stress	NN
cord-006229-7yoilsho	280	7	and	and	CC
cord-006229-7yoilsho	280	8	genomic	genomic	JJ
cord-006229-7yoilsho	280	9	damage	damage	NN
cord-006229-7yoilsho	280	10	in	in	IN
cord-006229-7yoilsho	280	11	comparison	comparison	NN
cord-006229-7yoilsho	280	12	to	to	TO
cord-006229-7yoilsho	280	13	lean	lean	VB
cord-006229-7yoilsho	280	14	rats	rat	NNS
cord-006229-7yoilsho	280	15	.	.	.
cord-006229-7yoilsho	281	1	After	after	IN
cord-006229-7yoilsho	281	2	body	body	NN
cord-006229-7yoilsho	281	3	weight	weight	NN
cord-006229-7yoilsho	281	4	loss	loss	NN
cord-006229-7yoilsho	281	5	,	,	,
cord-006229-7yoilsho	281	6	achieved	achieve	VBN
cord-006229-7yoilsho	281	7	by	by	IN
cord-006229-7yoilsho	281	8	either	either	CC
cord-006229-7yoilsho	281	9	RYGB	RYGB	NNP
cord-006229-7yoilsho	281	10	or	or	CC
cord-006229-7yoilsho	281	11	caloric	caloric	JJ
cord-006229-7yoilsho	281	12	restriction	restriction	NN
cord-006229-7yoilsho	281	13	alone	alone	RB
cord-006229-7yoilsho	281	14	,	,	,
cord-006229-7yoilsho	281	15	oxidative	oxidative	JJ
cord-006229-7yoilsho	281	16	stress	stress	NN
cord-006229-7yoilsho	281	17	level	level	NN
cord-006229-7yoilsho	281	18	and	and	CC
cord-006229-7yoilsho	281	19	genomic	genomic	JJ
cord-006229-7yoilsho	281	20	damage	damage	NN
cord-006229-7yoilsho	281	21	were	be	VBD
cord-006229-7yoilsho	281	22	decreased	decrease	VBN
cord-006229-7yoilsho	281	23	.	.	.
cord-006229-7yoilsho	282	1	This	this	DT
cord-006229-7yoilsho	282	2	may	may	MD
cord-006229-7yoilsho	282	3	indicate	indicate	VB
cord-006229-7yoilsho	282	4	a	a	DT
cord-006229-7yoilsho	282	5	reduction	reduction	NN
cord-006229-7yoilsho	282	6	of	of	IN
cord-006229-7yoilsho	282	7	the	the	DT
cord-006229-7yoilsho	282	8	elevated	elevated	JJ
cord-006229-7yoilsho	282	9	cancer	cancer	NN
cord-006229-7yoilsho	282	10	risk	risk	NN
cord-006229-7yoilsho	282	11	in	in	IN
cord-006229-7yoilsho	282	12	obesity	obesity	NN
cord-006229-7yoilsho	282	13	.	.	.
cord-006229-7yoilsho	282	14	)	)	-RRB-
cord-006229-7yoilsho	283	1	mice	mouse	NNS
cord-006229-7yoilsho	283	2	were	be	VBD
cord-006229-7yoilsho	283	3	treated	treat	VBN
cord-006229-7yoilsho	283	4	with	with	IN
cord-006229-7yoilsho	283	5	the	the	DT
cord-006229-7yoilsho	283	6	NOCrelated	nocrelated	JJ
cord-006229-7yoilsho	283	7	compound	compound	NN
cord-006229-7yoilsho	283	8	azoxymethane	azoxymethane	NNP
cord-006229-7yoilsho	283	9	(	(	-LRB-
cord-006229-7yoilsho	283	10	AOM	AOM	NNP
cord-006229-7yoilsho	283	11	)	)	-RRB-
cord-006229-7yoilsho	283	12	followed	follow	VBN
cord-006229-7yoilsho	283	13	by	by	IN
cord-006229-7yoilsho	283	14	the	the	DT
cord-006229-7yoilsho	283	15	administration	administration	NN
cord-006229-7yoilsho	283	16	of	of	IN
cord-006229-7yoilsho	283	17	dextran	dextran	NN
cord-006229-7yoilsho	283	18	sodium	sodium	NN
cord-006229-7yoilsho	283	19	sulfate	sulfate	NN
cord-006229-7yoilsho	283	20	to	to	TO
cord-006229-7yoilsho	283	21	trigger	trigger	VB
cord-006229-7yoilsho	283	22	CRC	CRC	NNP
cord-006229-7yoilsho	283	23	.	.	.
cord-006229-7yoilsho	284	1	Tumors	tumor	NNS
cord-006229-7yoilsho	284	2	were	be	VBD
cord-006229-7yoilsho	284	3	quantified	quantify	VBN
cord-006229-7yoilsho	284	4	by	by	IN
cord-006229-7yoilsho	284	5	non	non	JJ
cord-006229-7yoilsho	284	6	-	-	JJ
cord-006229-7yoilsho	284	7	invasive	invasive	JJ
cord-006229-7yoilsho	284	8	mini	mini	NN
cord-006229-7yoilsho	284	9	-	-	HYPH
cord-006229-7yoilsho	284	10	endoscopy	endoscopy	JJ
cord-006229-7yoilsho	284	11	,	,	,
cord-006229-7yoilsho	284	12	which	which	WDT
cord-006229-7yoilsho	284	13	revealed	reveal	VBD
cord-006229-7yoilsho	284	14	a	a	DT
cord-006229-7yoilsho	284	15	non	non	JJ
cord-006229-7yoilsho	284	16	-	-	JJ
cord-006229-7yoilsho	284	17	linear	linear	JJ
cord-006229-7yoilsho	284	18	increase	increase	NN
cord-006229-7yoilsho	284	19	in	in	IN
cord-006229-7yoilsho	284	20	CRC	CRC	NNP
cord-006229-7yoilsho	284	21	formation	formation	NN
cord-006229-7yoilsho	284	22	in	in	IN
cord-006229-7yoilsho	284	23	WT	WT	NNP
cord-006229-7yoilsho	284	24	and	and	CC
cord-006229-7yoilsho	284	25	Aag	Aag	NNP
cord-006229-7yoilsho	284	26	-/mice	-/mice	NNP
cord-006229-7yoilsho	284	27	.	.	.
cord-006229-7yoilsho	285	1	In	in	IN
cord-006229-7yoilsho	285	2	contrast	contrast	NN
cord-006229-7yoilsho	285	3	,	,	,
cord-006229-7yoilsho	285	4	a	a	DT
cord-006229-7yoilsho	285	5	linear	linear	JJ
cord-006229-7yoilsho	285	6	dose	dose	NN
cord-006229-7yoilsho	285	7	-	-	HYPH
cord-006229-7yoilsho	285	8	dependent	dependent	JJ
cord-006229-7yoilsho	285	9	increase	increase	NN
cord-006229-7yoilsho	285	10	in	in	IN
cord-006229-7yoilsho	285	11	tumor	tumor	NN
cord-006229-7yoilsho	285	12	frequency	frequency	NN
cord-006229-7yoilsho	285	13	was	be	VBD
cord-006229-7yoilsho	285	14	observed	observe	VBN
cord-006229-7yoilsho	285	15	in	in	IN
cord-006229-7yoilsho	285	16	Mgmt	Mgmt	NNP
cord-006229-7yoilsho	285	17	-/and	-/and	HYPH
cord-006229-7yoilsho	285	18	Mgmt	Mgmt	NNP
cord-006229-7yoilsho	285	19	-/-/Aag	-/-/Aag	NNP
cord-006229-7yoilsho	285	20	-/mice	-/mice	XX
cord-006229-7yoilsho	285	21	.	.	.
cord-006229-7yoilsho	286	1	The	the	DT
cord-006229-7yoilsho	286	2	data	datum	NNS
cord-006229-7yoilsho	286	3	was	be	VBD
cord-006229-7yoilsho	286	4	corroborated	corroborate	VBN
cord-006229-7yoilsho	286	5	by	by	IN
cord-006229-7yoilsho	286	6	hockey	hockey	NN
cord-006229-7yoilsho	286	7	stick	stick	NN
cord-006229-7yoilsho	286	8	modeling	modeling	NN
cord-006229-7yoilsho	286	9	,	,	,
cord-006229-7yoilsho	286	10	which	which	WDT
cord-006229-7yoilsho	286	11	yielded	yield	VBD
cord-006229-7yoilsho	286	12	similar	similar	JJ
cord-006229-7yoilsho	286	13	carcinogenic	carcinogenic	JJ
cord-006229-7yoilsho	286	14	threshold	threshold	NN
cord-006229-7yoilsho	286	15	doses	dose	NNS
cord-006229-7yoilsho	286	16	for	for	IN
cord-006229-7yoilsho	286	17	WT	WT	NNP
cord-006229-7yoilsho	286	18	and	and	CC
cord-006229-7yoilsho	286	19	Aag	Aag	NNP
cord-006229-7yoilsho	286	20	-/mice	-/mice	NNP
cord-006229-7yoilsho	286	21	.	.	.
cord-006229-7yoilsho	287	1	O	o	UH
cord-006229-7yoilsho	287	2	6	6	CD
cord-006229-7yoilsho	287	3	-MeG	-meg	CD
cord-006229-7yoilsho	287	4	levels	level	NNS
cord-006229-7yoilsho	287	5	and	and	CC
cord-006229-7yoilsho	287	6	depletion	depletion	NN
cord-006229-7yoilsho	287	7	of	of	IN
cord-006229-7yoilsho	287	8	MGMT	MGMT	NNP
cord-006229-7yoilsho	287	9	activity	activity	NN
cord-006229-7yoilsho	287	10	correlated	correlate	VBD
cord-006229-7yoilsho	287	11	well	well	RB
cord-006229-7yoilsho	287	12	with	with	IN
cord-006229-7yoilsho	287	13	the	the	DT
cord-006229-7yoilsho	287	14	observed	observed	JJ
cord-006229-7yoilsho	287	15	dose	dose	NN
cord-006229-7yoilsho	287	16	-	-	HYPH
cord-006229-7yoilsho	287	17	response	response	NN
cord-006229-7yoilsho	287	18	in	in	IN
cord-006229-7yoilsho	287	19	CRC	CRC	NNP
cord-006229-7yoilsho	287	20	formation	formation	NN
cord-006229-7yoilsho	287	21	.	.	.
cord-006229-7yoilsho	288	1	AOM	AOM	NNP
cord-006229-7yoilsho	288	2	dose	dose	RB
cord-006229-7yoilsho	288	3	-	-	HYPH
cord-006229-7yoilsho	288	4	dependently	dependently	RB
cord-006229-7yoilsho	288	5	induced	induce	VBN
cord-006229-7yoilsho	288	6	double	double	JJ
cord-006229-7yoilsho	288	7	strand	strand	NN
cord-006229-7yoilsho	288	8	breaks	break	NNS
cord-006229-7yoilsho	288	9	(	(	-LRB-
cord-006229-7yoilsho	288	10	DSBs	dsb	NNS
cord-006229-7yoilsho	288	11	)	)	-RRB-
cord-006229-7yoilsho	288	12	in	in	IN
cord-006229-7yoilsho	288	13	colon	colon	NN
cord-006229-7yoilsho	288	14	crypts	crypt	NNS
cord-006229-7yoilsho	288	15	including	include	VBG
cord-006229-7yoilsho	288	16	in	in	IN
cord-006229-7yoilsho	288	17	Lgr5-positive	lgr5-positive	JJ
cord-006229-7yoilsho	288	18	colon	colon	NN
cord-006229-7yoilsho	288	19	stem	stem	NN
cord-006229-7yoilsho	288	20	cells	cell	NNS
cord-006229-7yoilsho	288	21	,	,	,
cord-006229-7yoilsho	288	22	which	which	WDT
cord-006229-7yoilsho	288	23	coincided	coincide	VBD
cord-006229-7yoilsho	288	24	with	with	IN
cord-006229-7yoilsho	288	25	ATR	ATR	NNP
cord-006229-7yoilsho	288	26	-	-	HYPH
cord-006229-7yoilsho	288	27	Chk1-p53	Chk1-p53	NNP
cord-006229-7yoilsho	288	28	signaling	signaling	NN
cord-006229-7yoilsho	288	29	.	.	.
cord-006229-7yoilsho	289	1	Intriguingly	intriguingly	RB
cord-006229-7yoilsho	289	2	,	,	,
cord-006229-7yoilsho	289	3	Mgmt	Mgmt	NNP
cord-006229-7yoilsho	289	4	-	-	HYPH
cord-006229-7yoilsho	289	5	deficient	deficient	JJ
cord-006229-7yoilsho	289	6	mice	mouse	NNS
cord-006229-7yoilsho	289	7	displayed	display	VBD
cord-006229-7yoilsho	289	8	significantly	significantly	RB
cord-006229-7yoilsho	289	9	enhanced	enhance	VBN
cord-006229-7yoilsho	289	10	levels	level	NNS
cord-006229-7yoilsho	289	11	of	of	IN
cord-006229-7yoilsho	289	12	γ	γ	NN
cord-006229-7yoilsho	289	13	-	-	HYPH
cord-006229-7yoilsho	289	14	H2AX	H2AX	NNP
cord-006229-7yoilsho	289	15	,	,	,
cord-006229-7yoilsho	289	16	suggesting	suggest	VBG
cord-006229-7yoilsho	289	17	the	the	DT
cord-006229-7yoilsho	289	18	usefulness	usefulness	NN
cord-006229-7yoilsho	289	19	of	of	IN
cord-006229-7yoilsho	289	20	γ	γ	NN
cord-006229-7yoilsho	289	21	-	-	HYPH
cord-006229-7yoilsho	289	22	H2AX	H2AX	NNP
cord-006229-7yoilsho	289	23	as	as	IN
cord-006229-7yoilsho	289	24	an	an	DT
cord-006229-7yoilsho	289	25	early	early	JJ
cord-006229-7yoilsho	289	26	genotoxicity	genotoxicity	NN
cord-006229-7yoilsho	289	27	marker	marker	NN
cord-006229-7yoilsho	289	28	in	in	IN
cord-006229-7yoilsho	289	29	the	the	DT
cord-006229-7yoilsho	289	30	colorectum	colorectum	NN
cord-006229-7yoilsho	289	31	.	.	.
cord-006229-7yoilsho	290	1	This	this	DT
cord-006229-7yoilsho	290	2	study	study	NN
cord-006229-7yoilsho	290	3	demonstrates	demonstrate	VBZ
cord-006229-7yoilsho	290	4	for	for	IN
cord-006229-7yoilsho	290	5	the	the	DT
cord-006229-7yoilsho	290	6	first	first	JJ
cord-006229-7yoilsho	290	7	time	time	NN
cord-006229-7yoilsho	290	8	a	a	DT
cord-006229-7yoilsho	290	9	non	non	JJ
cord-006229-7yoilsho	290	10	-	-	JJ
cord-006229-7yoilsho	290	11	linear	linear	JJ
cord-006229-7yoilsho	290	12	dose	dose	NN
cord-006229-7yoilsho	290	13	-	-	HYPH
cord-006229-7yoilsho	290	14	response	response	NN
cord-006229-7yoilsho	290	15	for	for	IN
cord-006229-7yoilsho	290	16	alkylation	alkylation	NN
cord-006229-7yoilsho	290	17	-	-	HYPH
cord-006229-7yoilsho	290	18	induced	induce	VBN
cord-006229-7yoilsho	290	19	carcinogenesis	carcinogenesis	NN
cord-006229-7yoilsho	290	20	and	and	CC
cord-006229-7yoilsho	290	21	reveals	reveal	VBZ
cord-006229-7yoilsho	290	22	DNA	dna	NN
cord-006229-7yoilsho	290	23	repair	repair	NN
cord-006229-7yoilsho	290	24	by	by	IN
cord-006229-7yoilsho	290	25	MGMT	MGMT	NNP
cord-006229-7yoilsho	290	26	,	,	,
cord-006229-7yoilsho	290	27	but	but	CC
cord-006229-7yoilsho	290	28	not	not	RB
cord-006229-7yoilsho	290	29	AAG	AAG	NNP
cord-006229-7yoilsho	290	30	,	,	,
cord-006229-7yoilsho	290	31	as	as	IN
cord-006229-7yoilsho	290	32	a	a	DT
cord-006229-7yoilsho	290	33	key	key	JJ
cord-006229-7yoilsho	290	34	node	node	NN
cord-006229-7yoilsho	290	35	in	in	IN
cord-006229-7yoilsho	290	36	determining	determine	VBG
cord-006229-7yoilsho	290	37	a	a	DT
cord-006229-7yoilsho	290	38	carcinogenic	carcinogenic	JJ
cord-006229-7yoilsho	290	39	threshold	threshold	NN
cord-006229-7yoilsho	290	40	at	at	IN
cord-006229-7yoilsho	290	41	low	low	JJ
cord-006229-7yoilsho	290	42	alkylation	alkylation	NN
cord-006229-7yoilsho	290	43	dose	dose	NN
cord-006229-7yoilsho	290	44	levels	level	NNS
cord-006229-7yoilsho	290	45	[	[	-LRB-
cord-006229-7yoilsho	290	46	2	2	CD
cord-006229-7yoilsho	290	47	]	]	-RRB-
cord-006229-7yoilsho	290	48	.	.	.
cord-006229-7yoilsho	291	1	Obesity	obesity	NN
cord-006229-7yoilsho	291	2	is	be	VBZ
cord-006229-7yoilsho	291	3	characterized	characterize	VBN
cord-006229-7yoilsho	291	4	as	as	IN
cord-006229-7yoilsho	291	5	a	a	DT
cord-006229-7yoilsho	291	6	status	status	NN
cord-006229-7yoilsho	291	7	where	where	WRB
cord-006229-7yoilsho	291	8	the	the	DT
cord-006229-7yoilsho	291	9	excessive	excessive	JJ
cord-006229-7yoilsho	291	10	accumulation	accumulation	NN
cord-006229-7yoilsho	291	11	of	of	IN
cord-006229-7yoilsho	291	12	fat	fat	NN
cord-006229-7yoilsho	291	13	in	in	IN
cord-006229-7yoilsho	291	14	adipocytes	adipocyte	NNS
cord-006229-7yoilsho	291	15	leads	lead	VBZ
cord-006229-7yoilsho	291	16	to	to	IN
cord-006229-7yoilsho	291	17	local	local	JJ
cord-006229-7yoilsho	291	18	inflammation	inflammation	NN
cord-006229-7yoilsho	291	19	and	and	CC
cord-006229-7yoilsho	291	20	hypoxia	hypoxia	NN
cord-006229-7yoilsho	291	21	;	;	:
cord-006229-7yoilsho	291	22	both	both	DT
cord-006229-7yoilsho	291	23	contributing	contribute	VBG
cord-006229-7yoilsho	291	24	to	to	IN
cord-006229-7yoilsho	291	25	severe	severe	JJ
cord-006229-7yoilsho	291	26	obesity	obesity	NN
cord-006229-7yoilsho	291	27	associated	associate	VBN
cord-006229-7yoilsho	291	28	co	co	NNS
cord-006229-7yoilsho	291	29	-	-	NNS
cord-006229-7yoilsho	291	30	morbidities	morbidity	NNS
cord-006229-7yoilsho	291	31	such	such	JJ
cord-006229-7yoilsho	291	32	as	as	IN
cord-006229-7yoilsho	291	33	cardiovascular	cardiovascular	JJ
cord-006229-7yoilsho	291	34	disease	disease	NN
cord-006229-7yoilsho	291	35	and	and	CC
cord-006229-7yoilsho	291	36	type	type	NN
cord-006229-7yoilsho	291	37	2	2	CD
cord-006229-7yoilsho	291	38	diabetes	diabetes	NN
cord-006229-7yoilsho	291	39	mellitus	mellitus	NN
cord-006229-7yoilsho	291	40	.	.	.
cord-006229-7yoilsho	292	1	Local	local	JJ
cord-006229-7yoilsho	292	2	inflammation	inflammation	NN
cord-006229-7yoilsho	292	3	is	be	VBZ
cord-006229-7yoilsho	292	4	mediated	mediate	VBN
cord-006229-7yoilsho	292	5	by	by	IN
cord-006229-7yoilsho	292	6	macrophages	macrophage	NNS
cord-006229-7yoilsho	292	7	,	,	,
cord-006229-7yoilsho	292	8	stromal	stromal	JJ
cord-006229-7yoilsho	292	9	vascular	vascular	JJ
cord-006229-7yoilsho	292	10	cells	cell	NNS
cord-006229-7yoilsho	292	11	,	,	,
cord-006229-7yoilsho	292	12	preadipocytes	preadipocyte	NNS
cord-006229-7yoilsho	292	13	,	,	,
cord-006229-7yoilsho	292	14	and	and	CC
cord-006229-7yoilsho	292	15	adipocytes	adipocyte	NNS
cord-006229-7yoilsho	292	16	as	as	RB
cord-006229-7yoilsho	292	17	well	well	RB
cord-006229-7yoilsho	292	18	as	as	IN
cord-006229-7yoilsho	292	19	by	by	IN
cord-006229-7yoilsho	292	20	a	a	DT
cord-006229-7yoilsho	292	21	number	number	NN
cord-006229-7yoilsho	292	22	of	of	IN
cord-006229-7yoilsho	292	23	proinflammatory	proinflammatory	JJ
cord-006229-7yoilsho	292	24	cytokines	cytokine	NNS
cord-006229-7yoilsho	292	25	and	and	CC
cord-006229-7yoilsho	292	26	chemokines	chemokine	NNS
cord-006229-7yoilsho	292	27	(	(	-LRB-
cord-006229-7yoilsho	292	28	1	1	CD
cord-006229-7yoilsho	292	29	)	)	-RRB-
cord-006229-7yoilsho	292	30	.	.	.
cord-006229-7yoilsho	293	1	In	in	IN
cord-006229-7yoilsho	293	2	particular	particular	JJ
cord-006229-7yoilsho	293	3	,	,	,
cord-006229-7yoilsho	293	4	the	the	DT
cord-006229-7yoilsho	293	5	chemokines	chemokine	NNS
cord-006229-7yoilsho	293	6	monocyte	monocyte	NNP
cord-006229-7yoilsho	293	7	chemoattractant	chemoattractant	NNP
cord-006229-7yoilsho	293	8	protein	protein	NN
cord-006229-7yoilsho	293	9	(	(	-LRB-
cord-006229-7yoilsho	293	10	MCP-1	MCP-1	NNP
cord-006229-7yoilsho	293	11	,	,	,
cord-006229-7yoilsho	293	12	CCL2	CCL2	NNP
cord-006229-7yoilsho	293	13	)	)	-RRB-
cord-006229-7yoilsho	293	14	,	,	,
cord-006229-7yoilsho	293	15	interleukin-8	interleukin-8	NNP
cord-006229-7yoilsho	293	16	(	(	-LRB-
cord-006229-7yoilsho	293	17	IL-8	IL-8	NNP
cord-006229-7yoilsho	293	18	/	/	SYM
cord-006229-7yoilsho	293	19	CXCL8	CXCL8	NNP
cord-006229-7yoilsho	293	20	)	)	-RRB-
cord-006229-7yoilsho	293	21	and	and	CC
cord-006229-7yoilsho	293	22	stromal	stromal	JJ
cord-006229-7yoilsho	293	23	cell	cell	NN
cord-006229-7yoilsho	293	24	-	-	HYPH
cord-006229-7yoilsho	293	25	derived	derive	VBN
cord-006229-7yoilsho	293	26	factor	factor	NN
cord-006229-7yoilsho	293	27	1	1	CD
cord-006229-7yoilsho	293	28	(	(	-LRB-
cord-006229-7yoilsho	293	29	SDF-1a	SDF-1a	NNP
cord-006229-7yoilsho	293	30	/	/	SYM
cord-006229-7yoilsho	293	31	CXCL12	CXCL12	NNP
cord-006229-7yoilsho	293	32	)	)	-RRB-
cord-006229-7yoilsho	293	33	secreted	secrete	VBN
cord-006229-7yoilsho	293	34	by	by	IN
cord-006229-7yoilsho	293	35	stromal	stromal	JJ
cord-006229-7yoilsho	293	36	vascular	vascular	JJ
cord-006229-7yoilsho	293	37	cells	cell	NNS
cord-006229-7yoilsho	293	38	,	,	,
cord-006229-7yoilsho	293	39	preadipocytes	preadipocyte	NNS
cord-006229-7yoilsho	293	40	,	,	,
cord-006229-7yoilsho	293	41	and	and	CC
cord-006229-7yoilsho	293	42	adipocytes	adipocyte	NNS
cord-006229-7yoilsho	293	43	exert	exert	VBP
cord-006229-7yoilsho	293	44	paracrine	paracrine	JJ
cord-006229-7yoilsho	293	45	effects	effect	NNS
cord-006229-7yoilsho	293	46	by	by	IN
cord-006229-7yoilsho	293	47	recruiting	recruit	VBG
cord-006229-7yoilsho	293	48	neutrophils	neutrophil	NNS
cord-006229-7yoilsho	293	49	,	,	,
cord-006229-7yoilsho	293	50	monocytes	monocyte	NNS
cord-006229-7yoilsho	293	51	/	/	SYM
cord-006229-7yoilsho	293	52	macrophages	macrophage	NNS
cord-006229-7yoilsho	293	53	,	,	,
cord-006229-7yoilsho	293	54	and	and	CC
cord-006229-7yoilsho	293	55	T	T	NNP
cord-006229-7yoilsho	293	56	-	-	HYPH
cord-006229-7yoilsho	293	57	and	and	CC
cord-006229-7yoilsho	293	58	B	b	NN
cord-006229-7yoilsho	293	59	-	-	HYPH
cord-006229-7yoilsho	293	60	cells	cell	NNS
cord-006229-7yoilsho	293	61	.	.	.
cord-006229-7yoilsho	294	1	Interestingly	interestingly	RB
cord-006229-7yoilsho	294	2	,	,	,
cord-006229-7yoilsho	294	3	deficiency	deficiency	NN
cord-006229-7yoilsho	294	4	in	in	IN
cord-006229-7yoilsho	294	5	CXCL14	CXCL14	NNP
cord-006229-7yoilsho	294	6	was	be	VBD
cord-006229-7yoilsho	294	7	shown	show	VBN
cord-006229-7yoilsho	294	8	to	to	TO
cord-006229-7yoilsho	294	9	attenuate	attenuate	VB
cord-006229-7yoilsho	294	10	obesity	obesity	NN
cord-006229-7yoilsho	294	11	in	in	IN
cord-006229-7yoilsho	294	12	mice	mouse	NNS
cord-006229-7yoilsho	294	13	(	(	-LRB-
cord-006229-7yoilsho	294	14	2	2	CD
cord-006229-7yoilsho	294	15	)	)	-RRB-
cord-006229-7yoilsho	294	16	.	.	.
cord-006229-7yoilsho	295	1	The	the	DT
cord-006229-7yoilsho	295	2	CC	CC	NNP
cord-006229-7yoilsho	295	3	chemokine	chemokine	NN
cord-006229-7yoilsho	295	4	CCL2	CCL2	NNP
cord-006229-7yoilsho	295	5	is	be	VBZ
cord-006229-7yoilsho	295	6	known	know	VBN
cord-006229-7yoilsho	295	7	to	to	TO
cord-006229-7yoilsho	295	8	stimulate	stimulate	VB
cord-006229-7yoilsho	295	9	CCR2	CCR2	NNP
cord-006229-7yoilsho	295	10	receptors	receptor	NNS
cord-006229-7yoilsho	295	11	,	,	,
cord-006229-7yoilsho	295	12	and	and	CC
cord-006229-7yoilsho	295	13	the	the	DT
cord-006229-7yoilsho	295	14	CXC	CXC	NNP
cord-006229-7yoilsho	295	15	chemokines	chemokine	NNS
cord-006229-7yoilsho	295	16	CXCL8	CXCL8	NNP
cord-006229-7yoilsho	295	17	and	and	CC
cord-006229-7yoilsho	295	18	CXCL12	CXCL12	NNP
cord-006229-7yoilsho	295	19	to	to	TO
cord-006229-7yoilsho	295	20	activate	activate	VB
cord-006229-7yoilsho	295	21	CXCR1	CXCR1	NNS
cord-006229-7yoilsho	295	22	and	and	CC
cord-006229-7yoilsho	295	23	CXCR2	CXCR2	NNS
cord-006229-7yoilsho	295	24	or	or	CC
cord-006229-7yoilsho	295	25	CXCR4	CXCR4	NNS
cord-006229-7yoilsho	295	26	and	and	CC
cord-006229-7yoilsho	295	27	CXCR7	cxcr7	XX
cord-006229-7yoilsho	295	28	,	,	,
cord-006229-7yoilsho	295	29	respectively	respectively	RB
cord-006229-7yoilsho	295	30	.	.	.
cord-006229-7yoilsho	296	1	The	the	DT
cord-006229-7yoilsho	296	2	receptor(s	receptor(s	NNP
cord-006229-7yoilsho	296	3	)	)	-RRB-
cord-006229-7yoilsho	296	4	activated	activate	VBN
cord-006229-7yoilsho	296	5	by	by	IN
cord-006229-7yoilsho	296	6	CXCL14	CXCL14	NNP
cord-006229-7yoilsho	296	7	is	be	VBZ
cord-006229-7yoilsho	296	8	currently	currently	RB
cord-006229-7yoilsho	296	9	unknown	unknown	JJ
cord-006229-7yoilsho	296	10	.	.	.
cord-006229-7yoilsho	297	1	A	a	DT
cord-006229-7yoilsho	297	2	role	role	NN
cord-006229-7yoilsho	297	3	of	of	IN
cord-006229-7yoilsho	297	4	CXCL14	CXCL14	NNP
cord-006229-7yoilsho	297	5	in	in	IN
cord-006229-7yoilsho	297	6	modulating	modulate	VBG
cord-006229-7yoilsho	297	7	CXCR4	cxcr4	NN
cord-006229-7yoilsho	297	8	signaling	signaling	NN
cord-006229-7yoilsho	297	9	has	have	VBZ
cord-006229-7yoilsho	297	10	been	be	VBN
cord-006229-7yoilsho	297	11	proposed	propose	VBN
cord-006229-7yoilsho	297	12	.	.	.
cord-006229-7yoilsho	298	1	We	-PRON-	PRP
cord-006229-7yoilsho	298	2	initiated	initiate	VBD
cord-006229-7yoilsho	298	3	our	-PRON-	PRP$
cord-006229-7yoilsho	298	4	studies	study	NNS
cord-006229-7yoilsho	298	5	to	to	TO
cord-006229-7yoilsho	298	6	determine	determine	VB
cord-006229-7yoilsho	298	7	the	the	DT
cord-006229-7yoilsho	298	8	presence	presence	NN
cord-006229-7yoilsho	298	9	and	and	CC
cord-006229-7yoilsho	298	10	functional	functional	JJ
cord-006229-7yoilsho	298	11	significance	significance	NN
cord-006229-7yoilsho	298	12	of	of	IN
cord-006229-7yoilsho	298	13	chemotaxin	chemotaxin	NNP
cord-006229-7yoilsho	298	14	receptors	receptor	NNS
cord-006229-7yoilsho	298	15	in	in	IN
cord-006229-7yoilsho	298	16	human	human	JJ
cord-006229-7yoilsho	298	17	adipocytes	adipocyte	NNS
cord-006229-7yoilsho	298	18	and	and	CC
cord-006229-7yoilsho	298	19	their	-PRON-	PRP$
cord-006229-7yoilsho	298	20	precursor	precursor	NN
cord-006229-7yoilsho	298	21	cells	cell	NNS
cord-006229-7yoilsho	298	22	.	.	.
cord-006229-7yoilsho	299	1	To	to	IN
cord-006229-7yoilsho	299	2	this	this	DT
cord-006229-7yoilsho	299	3	end	end	NN
cord-006229-7yoilsho	299	4	,	,	,
cord-006229-7yoilsho	299	5	the	the	DT
cord-006229-7yoilsho	299	6	mRNA	mRNA	NNP
cord-006229-7yoilsho	299	7	expression	expression	NN
cord-006229-7yoilsho	299	8	pattern	pattern	NN
cord-006229-7yoilsho	299	9	of	of	IN
cord-006229-7yoilsho	299	10	CC	cc	NN
cord-006229-7yoilsho	299	11	chemokine	chemokine	NN
cord-006229-7yoilsho	299	12	receptors	receptor	NNS
cord-006229-7yoilsho	299	13	,	,	,
cord-006229-7yoilsho	299	14	CXC	CXC	NNP
cord-006229-7yoilsho	299	15	chemokine	chemokine	NN
cord-006229-7yoilsho	299	16	receptors	receptor	NNS
cord-006229-7yoilsho	299	17	formylated	formylate	VBD
cord-006229-7yoilsho	299	18	peptide	peptide	JJ
cord-006229-7yoilsho	299	19	receptor	receptor	NN
cord-006229-7yoilsho	299	20	FPR1	FPR1	NNP
cord-006229-7yoilsho	299	21	and	and	CC
cord-006229-7yoilsho	299	22	the	the	DT
cord-006229-7yoilsho	299	23	related	related	JJ
cord-006229-7yoilsho	299	24	receptor	receptor	NN
cord-006229-7yoilsho	299	25	FPRL1	fprl1	NN
cord-006229-7yoilsho	299	26	,	,	,
cord-006229-7yoilsho	299	27	and	and	CC
cord-006229-7yoilsho	299	28	CC	CC	NNP
cord-006229-7yoilsho	299	29	and	and	CC
cord-006229-7yoilsho	299	30	CXC	CXC	NNP
cord-006229-7yoilsho	299	31	chemokines	chemokine	NNS
cord-006229-7yoilsho	299	32	was	be	VBD
cord-006229-7yoilsho	299	33	analyzed	analyze	VBN
cord-006229-7yoilsho	299	34	during	during	IN
cord-006229-7yoilsho	299	35	in	in	IN
cord-006229-7yoilsho	299	36	vitro	vitro	FW
cord-006229-7yoilsho	299	37	adipose	adipose	JJ
cord-006229-7yoilsho	299	38	differentiation	differentiation	NN
cord-006229-7yoilsho	299	39	of	of	IN
cord-006229-7yoilsho	299	40	human	human	JJ
cord-006229-7yoilsho	299	41	Simpson	Simpson	NNP
cord-006229-7yoilsho	299	42	-	-	HYPH
cord-006229-7yoilsho	299	43	Golabi	Golabi	NNP
cord-006229-7yoilsho	299	44	-	-	HYPH
cord-006229-7yoilsho	299	45	Behmel	Behmel	NNP
cord-006229-7yoilsho	299	46	-	-	HYPH
cord-006229-7yoilsho	299	47	Syndrome	Syndrome	NNP
cord-006229-7yoilsho	299	48	(	(	-LRB-
cord-006229-7yoilsho	299	49	SGBS	SGBS	NNP
cord-006229-7yoilsho	299	50	)	)	-RRB-
cord-006229-7yoilsho	299	51	preadipocytes	preadipocytes	NNP
cord-006229-7yoilsho	299	52	,	,	,
cord-006229-7yoilsho	299	53	and	and	CC
cord-006229-7yoilsho	299	54	under	under	IN
cord-006229-7yoilsho	299	55	conditions	condition	NNS
cord-006229-7yoilsho	299	56	mimicking	mimic	VBG
cord-006229-7yoilsho	299	57	an	an	DT
cord-006229-7yoilsho	299	58	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	299	59	response	response	NN
cord-006229-7yoilsho	299	60	.	.	.
cord-006229-7yoilsho	300	1	In	in	IN
cord-006229-7yoilsho	300	2	particular	particular	JJ
cord-006229-7yoilsho	300	3	,	,	,
cord-006229-7yoilsho	300	4	we	-PRON-	PRP
cord-006229-7yoilsho	300	5	focused	focus	VBD
cord-006229-7yoilsho	300	6	on	on	IN
cord-006229-7yoilsho	300	7	the	the	DT
cord-006229-7yoilsho	300	8	expression	expression	NN
cord-006229-7yoilsho	300	9	pattern	pattern	NN
cord-006229-7yoilsho	300	10	of	of	IN
cord-006229-7yoilsho	300	11	human	human	JJ
cord-006229-7yoilsho	300	12	CCR2	CCR2	NNP
cord-006229-7yoilsho	300	13	receptors	receptor	NNS
cord-006229-7yoilsho	300	14	,	,	,
cord-006229-7yoilsho	300	15	since	since	IN
cord-006229-7yoilsho	300	16	previous	previous	JJ
cord-006229-7yoilsho	300	17	reports	report	NNS
cord-006229-7yoilsho	300	18	indicated	indicate	VBD
cord-006229-7yoilsho	300	19	a	a	DT
cord-006229-7yoilsho	300	20	role	role	NN
cord-006229-7yoilsho	300	21	in	in	IN
cord-006229-7yoilsho	300	22	adipogenic	adipogenic	JJ
cord-006229-7yoilsho	300	23	differentiation	differentiation	NN
cord-006229-7yoilsho	300	24	.	.	.
cord-006229-7yoilsho	301	1	However	however	RB
cord-006229-7yoilsho	301	2	,	,	,
cord-006229-7yoilsho	301	3	our	-PRON-	PRP$
cord-006229-7yoilsho	301	4	comprehensive	comprehensive	JJ
cord-006229-7yoilsho	301	5	analysis	analysis	NN
cord-006229-7yoilsho	301	6	using	use	VBG
cord-006229-7yoilsho	301	7	different	different	JJ
cord-006229-7yoilsho	301	8	sources	source	NNS
cord-006229-7yoilsho	301	9	of	of	IN
cord-006229-7yoilsho	301	10	adipocytes	adipocyte	NNS
cord-006229-7yoilsho	301	11	and	and	CC
cord-006229-7yoilsho	301	12	their	-PRON-	PRP$
cord-006229-7yoilsho	301	13	precursors	precursor	NNS
cord-006229-7yoilsho	301	14	indicated	indicate	VBD
cord-006229-7yoilsho	301	15	that	that	IN
cord-006229-7yoilsho	301	16	CCR2	CCR2	NNP
cord-006229-7yoilsho	301	17	receptors	receptor	NNS
cord-006229-7yoilsho	301	18	were	be	VBD
cord-006229-7yoilsho	301	19	absent	absent	JJ
cord-006229-7yoilsho	301	20	(	(	-LRB-
cord-006229-7yoilsho	301	21	3	3	CD
cord-006229-7yoilsho	301	22	)	)	-RRB-
cord-006229-7yoilsho	301	23	.	.	.
cord-006229-7yoilsho	302	1	Yet	yet	RB
cord-006229-7yoilsho	302	2	,	,	,
cord-006229-7yoilsho	302	3	the	the	DT
cord-006229-7yoilsho	302	4	analysis	analysis	NN
cord-006229-7yoilsho	302	5	revealed	reveal	VBD
cord-006229-7yoilsho	302	6	appreciable	appreciable	JJ
cord-006229-7yoilsho	302	7	levels	level	NNS
cord-006229-7yoilsho	302	8	of	of	IN
cord-006229-7yoilsho	302	9	mRNA	mrna	NN
cord-006229-7yoilsho	302	10	encoding	encode	VBG
cord-006229-7yoilsho	302	11	CCL2	CCL2	NNP
cord-006229-7yoilsho	302	12	,	,	,
cord-006229-7yoilsho	302	13	CXCL12	CXCL12	NNP
cord-006229-7yoilsho	302	14	,	,	,
cord-006229-7yoilsho	302	15	and	and	CC
cord-006229-7yoilsho	302	16	CXCL14	CXCL14	NNP
cord-006229-7yoilsho	302	17	,	,	,
cord-006229-7yoilsho	302	18	and	and	CC
cord-006229-7yoilsho	302	19	CCR1	CCR1	NNP
cord-006229-7yoilsho	302	20	,	,	,
cord-006229-7yoilsho	302	21	CXCR2	CXCR2	NNS
cord-006229-7yoilsho	302	22	,	,	,
cord-006229-7yoilsho	302	23	CXCR7	cxcr7	XX
cord-006229-7yoilsho	302	24	,	,	,
cord-006229-7yoilsho	302	25	FPR1	FPR1	NNP
cord-006229-7yoilsho	302	26	,	,	,
cord-006229-7yoilsho	302	27	and	and	CC
cord-006229-7yoilsho	302	28	FPRL1	FPRL1	NNS
cord-006229-7yoilsho	302	29	,	,	,
cord-006229-7yoilsho	302	30	and	and	CC
cord-006229-7yoilsho	302	31	CXCR4	CXCR4	NNS
cord-006229-7yoilsho	302	32	.	.	.
cord-006229-7yoilsho	303	1	Of	of	IN
cord-006229-7yoilsho	303	2	interest	interest	NN
cord-006229-7yoilsho	303	3	,	,	,
cord-006229-7yoilsho	303	4	CXCR4-and	CXCR4-and	NNP
cord-006229-7yoilsho	303	5	CXCR7-mRNA	CXCR7-mRNA	NNS
cord-006229-7yoilsho	303	6	were	be	VBD
cord-006229-7yoilsho	303	7	found	find	VBN
cord-006229-7yoilsho	303	8	to	to	TO
cord-006229-7yoilsho	303	9	be	be	VB
cord-006229-7yoilsho	303	10	up	up	RB
cord-006229-7yoilsho	303	11	-	-	HYPH
cord-006229-7yoilsho	303	12	regulated	regulate	VBN
cord-006229-7yoilsho	303	13	under	under	IN
cord-006229-7yoilsho	303	14	the	the	DT
cord-006229-7yoilsho	303	15	proinflammatory	proinflammatory	JJ
cord-006229-7yoilsho	303	16	conditions	condition	NNS
cord-006229-7yoilsho	303	17	.	.	.
cord-006229-7yoilsho	304	1	To	to	TO
cord-006229-7yoilsho	304	2	analyze	analyze	VB
cord-006229-7yoilsho	304	3	the	the	DT
cord-006229-7yoilsho	304	4	responses	response	NNS
cord-006229-7yoilsho	304	5	of	of	IN
cord-006229-7yoilsho	304	6	adipocytes	adipocyte	NNS
cord-006229-7yoilsho	304	7	and	and	CC
cord-006229-7yoilsho	304	8	their	-PRON-	PRP$
cord-006229-7yoilsho	304	9	precursors	precursor	NNS
cord-006229-7yoilsho	304	10	to	to	IN
cord-006229-7yoilsho	304	11	chemokine	chemokine	JJ
cord-006229-7yoilsho	304	12	receptor	receptor	NN
cord-006229-7yoilsho	304	13	agonists	agonist	NNS
cord-006229-7yoilsho	304	14	,	,	,
cord-006229-7yoilsho	304	15	we	-PRON-	PRP
cord-006229-7yoilsho	304	16	used	use	VBD
cord-006229-7yoilsho	304	17	chemokine	chemokine	NN
cord-006229-7yoilsho	304	18	-	-	HYPH
cord-006229-7yoilsho	304	19	mCherry	mcherry	NN
cord-006229-7yoilsho	304	20	fusion	fusion	NN
cord-006229-7yoilsho	304	21	proteins	protein	NNS
cord-006229-7yoilsho	304	22	purified	purify	VBN
cord-006229-7yoilsho	304	23	from	from	IN
cord-006229-7yoilsho	304	24	baculovirus	baculovirus	NN
cord-006229-7yoilsho	304	25	-	-	HYPH
cord-006229-7yoilsho	304	26	infected	infect	VBN
cord-006229-7yoilsho	304	27	insect	insect	NN
cord-006229-7yoilsho	304	28	cells	cell	NNS
cord-006229-7yoilsho	304	29	,	,	,
cord-006229-7yoilsho	304	30	e.g	e.g	NNP
cord-006229-7yoilsho	304	31	CCL2	CCL2	NNP
cord-006229-7yoilsho	304	32	,	,	,
cord-006229-7yoilsho	304	33	CXCL12	CXCL12	NNP
cord-006229-7yoilsho	304	34	,	,	,
cord-006229-7yoilsho	305	1	CXCL14	CXCL14	NNP
cord-006229-7yoilsho	305	2	.	.	.
cord-006229-7yoilsho	306	1	While	while	IN
cord-006229-7yoilsho	306	2	SGBSpreadipocytes	sgbspreadipocyte	NNS
cord-006229-7yoilsho	306	3	and	and	CC
cord-006229-7yoilsho	306	4	adipocytes	adipocyte	NNS
cord-006229-7yoilsho	306	5	did	do	VBD
cord-006229-7yoilsho	306	6	not	not	RB
cord-006229-7yoilsho	306	7	accumulate	accumulate	VB
cord-006229-7yoilsho	306	8	CCL2-mCherry	ccl2-mcherry	NN
cord-006229-7yoilsho	306	9	upon	upon	IN
cord-006229-7yoilsho	306	10	stimulation	stimulation	NN
cord-006229-7yoilsho	306	11	,	,	,
cord-006229-7yoilsho	306	12	they	-PRON-	PRP
cord-006229-7yoilsho	306	13	showed	show	VBD
cord-006229-7yoilsho	306	14	a	a	DT
cord-006229-7yoilsho	306	15	small	small	JJ
cord-006229-7yoilsho	306	16	accumulation	accumulation	NN
cord-006229-7yoilsho	306	17	of	of	IN
cord-006229-7yoilsho	306	18	CXCL12-mCherry	CXCL12-mCherry	NNP
cord-006229-7yoilsho	306	19	,	,	,
cord-006229-7yoilsho	306	20	and	and	CC
cord-006229-7yoilsho	306	21	a	a	DT
cord-006229-7yoilsho	306	22	strong	strong	JJ
cord-006229-7yoilsho	306	23	accumulation	accumulation	NN
cord-006229-7yoilsho	306	24	of	of	IN
cord-006229-7yoilsho	306	25	CXCL14-mCherry	CXCL14-mCherry	NNP
cord-006229-7yoilsho	306	26	in	in	IN
cord-006229-7yoilsho	306	27	the	the	DT
cord-006229-7yoilsho	306	28	endosomal	endosomal	NNP
cord-006229-7yoilsho	306	29	compartment	compartment	NN
cord-006229-7yoilsho	306	30	.	.	.
cord-006229-7yoilsho	307	1	Similar	similar	JJ
cord-006229-7yoilsho	307	2	results	result	NNS
cord-006229-7yoilsho	307	3	were	be	VBD
cord-006229-7yoilsho	307	4	obtained	obtain	VBN
cord-006229-7yoilsho	307	5	in	in	IN
cord-006229-7yoilsho	307	6	murine	murine	NN
cord-006229-7yoilsho	307	7	3T3L-1	3t3l-1	CD
cord-006229-7yoilsho	307	8	preadipocytes	preadipocyte	NNS
cord-006229-7yoilsho	307	9	.	.	.
cord-006229-7yoilsho	308	1	Using	use	VBG
cord-006229-7yoilsho	308	2	mass	mass	NN
cord-006229-7yoilsho	308	3	spectrometry	spectrometry	NN
cord-006229-7yoilsho	308	4	analysis	analysis	NN
cord-006229-7yoilsho	308	5	,	,	,
cord-006229-7yoilsho	308	6	we	-PRON-	PRP
cord-006229-7yoilsho	308	7	set	set	VBD
cord-006229-7yoilsho	308	8	out	out	RP
cord-006229-7yoilsho	308	9	to	to	TO
cord-006229-7yoilsho	308	10	identify	identify	VB
cord-006229-7yoilsho	308	11	the	the	DT
cord-006229-7yoilsho	308	12	CXCL14-binding	cxcl14-binde	VBG
cord-006229-7yoilsho	308	13	putative	putative	JJ
cord-006229-7yoilsho	308	14	receptor	receptor	NN
cord-006229-7yoilsho	308	15	protein(s	protein(s	NNP
cord-006229-7yoilsho	308	16	)	)	-RRB-
cord-006229-7yoilsho	308	17	in	in	IN
cord-006229-7yoilsho	308	18	murine	murine	JJ
cord-006229-7yoilsho	308	19	3T3L-1	3t3l-1	CD
cord-006229-7yoilsho	308	20	preadipocytes	preadipocyte	NNS
cord-006229-7yoilsho	308	21	.	.	.
cord-006229-7yoilsho	309	1	(	(	-LRB-
cord-006229-7yoilsho	309	2	1	1	LS
cord-006229-7yoilsho	309	3	)	)	-RRB-
cord-006229-7yoilsho	309	4	Makki	Makki	NNP
cord-006229-7yoilsho	309	5	,	,	,
cord-006229-7yoilsho	309	6	K.	K.	NNP
cord-006229-7yoilsho	309	7	et	et	NNP
cord-006229-7yoilsho	309	8	al	al	NNP
cord-006229-7yoilsho	309	9	.	.	NNP
cord-006229-7yoilsho	309	10	,	,	,
cord-006229-7yoilsho	309	11	(	(	-LRB-
cord-006229-7yoilsho	309	12	2013	2013	CD
cord-006229-7yoilsho	309	13	)	)	-RRB-
cord-006229-7yoilsho	310	1	In	in	IN
cord-006229-7yoilsho	310	2	personalized	personalized	JJ
cord-006229-7yoilsho	310	3	medicine	medicine	NN
cord-006229-7yoilsho	310	4	tumors	tumor	NNS
cord-006229-7yoilsho	310	5	are	be	VBP
cord-006229-7yoilsho	310	6	screened	screen	VBN
cord-006229-7yoilsho	310	7	for	for	IN
cord-006229-7yoilsho	310	8	several	several	JJ
cord-006229-7yoilsho	310	9	mutations	mutation	NNS
cord-006229-7yoilsho	310	10	in	in	IN
cord-006229-7yoilsho	310	11	oncogenes	oncogene	NNS
cord-006229-7yoilsho	310	12	or	or	CC
cord-006229-7yoilsho	310	13	tumor	tumor	NN
cord-006229-7yoilsho	310	14	suppressors	suppressor	NNS
cord-006229-7yoilsho	310	15	.	.	.
cord-006229-7yoilsho	311	1	However	however	RB
cord-006229-7yoilsho	311	2	,	,	,
cord-006229-7yoilsho	311	3	the	the	DT
cord-006229-7yoilsho	311	4	cellular	cellular	JJ
cord-006229-7yoilsho	311	5	protein	protein	NN
cord-006229-7yoilsho	311	6	content	content	NN
cord-006229-7yoilsho	311	7	not	not	RB
cord-006229-7yoilsho	311	8	exclusively	exclusively	RB
cord-006229-7yoilsho	311	9	depends	depend	VBZ
cord-006229-7yoilsho	311	10	on	on	IN
cord-006229-7yoilsho	311	11	the	the	DT
cord-006229-7yoilsho	311	12	DNA	dna	NN
cord-006229-7yoilsho	311	13	.	.	.
cord-006229-7yoilsho	312	1	We	-PRON-	PRP
cord-006229-7yoilsho	312	2	identified	identify	VBD
cord-006229-7yoilsho	312	3	new	new	JJ
cord-006229-7yoilsho	312	4	Rac	Rac	NNP
cord-006229-7yoilsho	312	5	variants	variant	NNS
cord-006229-7yoilsho	312	6	generated	generate	VBN
cord-006229-7yoilsho	312	7	on	on	IN
cord-006229-7yoilsho	312	8	the	the	DT
cord-006229-7yoilsho	312	9	mRNA	mRNA	NNP
cord-006229-7yoilsho	312	10	level	level	NN
cord-006229-7yoilsho	312	11	in	in	IN
cord-006229-7yoilsho	312	12	androgenindependent	androgenindependent	NN
cord-006229-7yoilsho	312	13	prostate	prostate	NN
cord-006229-7yoilsho	312	14	cancer	cancer	NN
cord-006229-7yoilsho	312	15	cells	cell	NNS
cord-006229-7yoilsho	312	16	.	.	.
cord-006229-7yoilsho	313	1	All	all	DT
cord-006229-7yoilsho	313	2	variants	variant	NNS
cord-006229-7yoilsho	313	3	represent	represent	VBP
cord-006229-7yoilsho	313	4	active	active	JJ
cord-006229-7yoilsho	313	5	forms	form	NNS
cord-006229-7yoilsho	313	6	of	of	IN
cord-006229-7yoilsho	313	7	the	the	DT
cord-006229-7yoilsho	313	8	GTPase	GTPase	NNP
cord-006229-7yoilsho	313	9	.	.	.
cord-006229-7yoilsho	314	1	They	-PRON-	PRP
cord-006229-7yoilsho	314	2	are	be	VBP
cord-006229-7yoilsho	314	3	capable	capable	JJ
cord-006229-7yoilsho	314	4	to	to	TO
cord-006229-7yoilsho	314	5	suppress	suppress	VB
cord-006229-7yoilsho	314	6	RhoA	RhoA	NNP
cord-006229-7yoilsho	314	7	-	-	HYPH
cord-006229-7yoilsho	314	8	induced	induce	VBN
cord-006229-7yoilsho	314	9	apoptosis	apoptosis	NN
cord-006229-7yoilsho	314	10	and	and	CC
cord-006229-7yoilsho	314	11	additionally	additionally	RB
cord-006229-7yoilsho	314	12	,	,	,
cord-006229-7yoilsho	314	13	mediate	mediate	VB
cord-006229-7yoilsho	314	14	the	the	DT
cord-006229-7yoilsho	314	15	synthesis	synthesis	NN
cord-006229-7yoilsho	314	16	of	of	IN
cord-006229-7yoilsho	314	17	genes	gene	NNS
cord-006229-7yoilsho	314	18	which	which	WDT
cord-006229-7yoilsho	314	19	are	be	VBP
cord-006229-7yoilsho	314	20	under	under	IN
cord-006229-7yoilsho	314	21	the	the	DT
cord-006229-7yoilsho	314	22	control	control	NN
cord-006229-7yoilsho	314	23	of	of	IN
cord-006229-7yoilsho	314	24	the	the	DT
cord-006229-7yoilsho	314	25	androgen	androgen	NN
cord-006229-7yoilsho	314	26	receptor	receptor	NN
cord-006229-7yoilsho	314	27	.	.	.
cord-006229-7yoilsho	315	1	Importantly	importantly	RB
cord-006229-7yoilsho	315	2	,	,	,
cord-006229-7yoilsho	315	3	expression	expression	NN
cord-006229-7yoilsho	315	4	of	of	IN
cord-006229-7yoilsho	315	5	the	the	DT
cord-006229-7yoilsho	315	6	Rac	Rac	NNP
cord-006229-7yoilsho	315	7	variants	variant	NNS
cord-006229-7yoilsho	315	8	is	be	VBZ
cord-006229-7yoilsho	315	9	sufficient	sufficient	JJ
cord-006229-7yoilsho	315	10	to	to	TO
cord-006229-7yoilsho	315	11	support	support	VB
cord-006229-7yoilsho	315	12	tumor	tumor	NN
cord-006229-7yoilsho	315	13	growth	growth	NN
cord-006229-7yoilsho	315	14	in	in	IN
cord-006229-7yoilsho	315	15	mice	mouse	NNS
cord-006229-7yoilsho	315	16	.	.	.
cord-006229-7yoilsho	316	1	We	-PRON-	PRP
cord-006229-7yoilsho	316	2	prove	prove	VBP
cord-006229-7yoilsho	316	3	the	the	DT
cord-006229-7yoilsho	316	4	existence	existence	NN
cord-006229-7yoilsho	316	5	of	of	IN
cord-006229-7yoilsho	316	6	the	the	DT
cord-006229-7yoilsho	316	7	variants	variant	NNS
cord-006229-7yoilsho	316	8	and	and	CC
cord-006229-7yoilsho	316	9	verify	verify	VB
cord-006229-7yoilsho	316	10	their	-PRON-	PRP$
cord-006229-7yoilsho	316	11	clinical	clinical	JJ
cord-006229-7yoilsho	316	12	appearance	appearance	NN
cord-006229-7yoilsho	316	13	and	and	CC
cord-006229-7yoilsho	316	14	relevance	relevance	NN
cord-006229-7yoilsho	316	15	in	in	IN
cord-006229-7yoilsho	316	16	tissue	tissue	NN
cord-006229-7yoilsho	316	17	samples	sample	NNS
cord-006229-7yoilsho	316	18	of	of	IN
cord-006229-7yoilsho	316	19	a	a	DT
cord-006229-7yoilsho	316	20	prostate	prostate	NN
cord-006229-7yoilsho	316	21	cancer	cancer	NN
cord-006229-7yoilsho	316	22	patient	patient	NN
cord-006229-7yoilsho	316	23	.	.	.
cord-006229-7yoilsho	317	1	DNA	dna	NN
cord-006229-7yoilsho	317	2	analysis	analysis	NN
cord-006229-7yoilsho	317	3	,	,	,
cord-006229-7yoilsho	317	4	however	however	RB
cord-006229-7yoilsho	317	5	,	,	,
cord-006229-7yoilsho	317	6	revealed	reveal	VBD
cord-006229-7yoilsho	317	7	the	the	DT
cord-006229-7yoilsho	317	8	wildtype	wildtype	JJ
cord-006229-7yoilsho	317	9	sequence	sequence	NN
cord-006229-7yoilsho	317	10	of	of	IN
cord-006229-7yoilsho	317	11	rac	rac	NNP
cord-006229-7yoilsho	317	12	.	.	.
cord-006229-7yoilsho	318	1	Therefore	therefore	RB
cord-006229-7yoilsho	318	2	,	,	,
cord-006229-7yoilsho	318	3	routine	routine	JJ
cord-006229-7yoilsho	318	4	analysis	analysis	NN
cord-006229-7yoilsho	318	5	of	of	IN
cord-006229-7yoilsho	318	6	patient	patient	JJ
cord-006229-7yoilsho	318	7	tumor	tumor	NN
cord-006229-7yoilsho	318	8	tissue	tissue	NN
cord-006229-7yoilsho	318	9	would	would	MD
cord-006229-7yoilsho	318	10	miss	miss	VB
cord-006229-7yoilsho	318	11	the	the	DT
cord-006229-7yoilsho	318	12	detection	detection	NN
cord-006229-7yoilsho	318	13	of	of	IN
cord-006229-7yoilsho	318	14	active	active	JJ
cord-006229-7yoilsho	318	15	Rac	Rac	NNP
cord-006229-7yoilsho	318	16	which	which	WDT
cord-006229-7yoilsho	318	17	precludes	preclude	VBZ
cord-006229-7yoilsho	318	18	the	the	DT
cord-006229-7yoilsho	318	19	success	success	NN
cord-006229-7yoilsho	318	20	of	of	IN
cord-006229-7yoilsho	318	21	therapy	therapy	NN
cord-006229-7yoilsho	318	22	.	.	.
cord-006229-7yoilsho	319	1	The	the	DT
cord-006229-7yoilsho	319	2	existence	existence	NN
cord-006229-7yoilsho	319	3	of	of	IN
cord-006229-7yoilsho	319	4	active	active	JJ
cord-006229-7yoilsho	319	5	Rac	Rac	NNP
cord-006229-7yoilsho	319	6	variants	variant	NNS
cord-006229-7yoilsho	319	7	in	in	IN
cord-006229-7yoilsho	319	8	prostate	prostate	NN
cord-006229-7yoilsho	319	9	cancer	cancer	NN
cord-006229-7yoilsho	319	10	tissue	tissue	NN
cord-006229-7yoilsho	319	11	that	that	WDT
cord-006229-7yoilsho	319	12	promote	promote	VBP
cord-006229-7yoilsho	319	13	resistance	resistance	NN
cord-006229-7yoilsho	319	14	towards	towards	IN
cord-006229-7yoilsho	319	15	androgen	androgen	NN
cord-006229-7yoilsho	319	16	deprivation	deprivation	NN
cord-006229-7yoilsho	319	17	suggest	suggest	VBP
cord-006229-7yoilsho	319	18	Rac	Rac	NNP
cord-006229-7yoilsho	319	19	inhibition	inhibition	NN
cord-006229-7yoilsho	319	20	as	as	IN
cord-006229-7yoilsho	319	21	an	an	DT
cord-006229-7yoilsho	319	22	effective	effective	JJ
cord-006229-7yoilsho	319	23	add	add	NN
cord-006229-7yoilsho	319	24	on	on	IN
cord-006229-7yoilsho	319	25	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	319	26	strategy	strategy	NN
cord-006229-7yoilsho	319	27	against	against	IN
cord-006229-7yoilsho	319	28	prostate	prostate	NN
cord-006229-7yoilsho	319	29	cancer	cancer	NN
cord-006229-7yoilsho	319	30	.	.	.
cord-006229-7yoilsho	320	1	The	the	DT
cord-006229-7yoilsho	320	2	bacterial	bacterial	JJ
cord-006229-7yoilsho	320	3	effector	effector	NN
cord-006229-7yoilsho	320	4	protein	protein	NN
cord-006229-7yoilsho	320	5	Exotoxin	Exotoxin	NNP
cord-006229-7yoilsho	320	6	Y	Y	NNP
cord-006229-7yoilsho	320	7	(	(	-LRB-
cord-006229-7yoilsho	320	8	ExoY	ExoY	NNP
cord-006229-7yoilsho	320	9	)	)	-RRB-
cord-006229-7yoilsho	320	10	of	of	IN
cord-006229-7yoilsho	320	11	Pseudomonas	Pseudomonas	NNP
cord-006229-7yoilsho	320	12	aeruginosa	aeruginosa	NN
cord-006229-7yoilsho	320	13	is	be	VBZ
cord-006229-7yoilsho	320	14	delivered	deliver	VBN
cord-006229-7yoilsho	320	15	into	into	IN
cord-006229-7yoilsho	320	16	host	host	NN
cord-006229-7yoilsho	320	17	cells	cell	NNS
cord-006229-7yoilsho	320	18	via	via	IN
cord-006229-7yoilsho	320	19	the	the	DT
cord-006229-7yoilsho	320	20	bacterial	bacterial	JJ
cord-006229-7yoilsho	320	21	type	type	NN
cord-006229-7yoilsho	320	22	III	iii	CD
cord-006229-7yoilsho	320	23	secretion	secretion	NN
cord-006229-7yoilsho	320	24	system	system	NN
cord-006229-7yoilsho	320	25	.	.	.
cord-006229-7yoilsho	321	1	Once	once	RB
cord-006229-7yoilsho	321	2	arrived	arrive	VBN
cord-006229-7yoilsho	321	3	in	in	IN
cord-006229-7yoilsho	321	4	the	the	DT
cord-006229-7yoilsho	321	5	host	host	NN
cord-006229-7yoilsho	321	6	cell	cell	NN
cord-006229-7yoilsho	321	7	nucleotidyl	nucleotidyl	NN
cord-006229-7yoilsho	321	8	cyclase	cyclase	NN
cord-006229-7yoilsho	321	9	activity	activity	NN
cord-006229-7yoilsho	321	10	of	of	IN
cord-006229-7yoilsho	321	11	ExoY	ExoY	NNP
cord-006229-7yoilsho	321	12	is	be	VBZ
cord-006229-7yoilsho	321	13	activated	activate	VBN
cord-006229-7yoilsho	321	14	by	by	IN
cord-006229-7yoilsho	321	15	a	a	DT
cord-006229-7yoilsho	321	16	yet	yet	RB
cord-006229-7yoilsho	321	17	unknown	unknown	JJ
cord-006229-7yoilsho	321	18	cofactor	cofactor	NN
cord-006229-7yoilsho	321	19	and	and	CC
cord-006229-7yoilsho	321	20	thus	thus	RB
cord-006229-7yoilsho	321	21	has	have	VBZ
cord-006229-7yoilsho	321	22	a	a	DT
cord-006229-7yoilsho	321	23	profound	profound	JJ
cord-006229-7yoilsho	321	24	effect	effect	NN
cord-006229-7yoilsho	321	25	on	on	IN
cord-006229-7yoilsho	321	26	concentrations	concentration	NNS
cord-006229-7yoilsho	321	27	of	of	IN
cord-006229-7yoilsho	321	28	cyclic	cyclic	JJ
cord-006229-7yoilsho	321	29	nucleotides	nucleotide	NNS
cord-006229-7yoilsho	321	30	:	:	:
cord-006229-7yoilsho	322	1	In	in	IN
cord-006229-7yoilsho	322	2	addition	addition	NN
cord-006229-7yoilsho	322	3	to	to	IN
cord-006229-7yoilsho	322	4	production	production	NN
cord-006229-7yoilsho	322	5	of	of	IN
cord-006229-7yoilsho	322	6	cyclic	cyclic	JJ
cord-006229-7yoilsho	322	7	AMP	AMP	NNP
cord-006229-7yoilsho	322	8	(	(	-LRB-
cord-006229-7yoilsho	322	9	cAMP	camp	NN
cord-006229-7yoilsho	322	10	)	)	-RRB-
cord-006229-7yoilsho	322	11	and	and	CC
cord-006229-7yoilsho	322	12	cyclic	cyclic	JJ
cord-006229-7yoilsho	322	13	GMP	GMP	NNP
cord-006229-7yoilsho	322	14	(	(	-LRB-
cord-006229-7yoilsho	322	15	cGMP	cGMP	NNP
cord-006229-7yoilsho	322	16	)	)	-RRB-
cord-006229-7yoilsho	322	17	there	there	EX
cord-006229-7yoilsho	322	18	is	be	VBZ
cord-006229-7yoilsho	322	19	a	a	DT
cord-006229-7yoilsho	322	20	massive	massive	JJ
cord-006229-7yoilsho	322	21	synthesis	synthesis	NN
cord-006229-7yoilsho	322	22	of	of	IN
cord-006229-7yoilsho	322	23	cyclic	cyclic	JJ
cord-006229-7yoilsho	322	24	3	3	CD
cord-006229-7yoilsho	322	25	'	'	''
cord-006229-7yoilsho	322	26	,	,	,
cord-006229-7yoilsho	322	27	and	and	CC
cord-006229-7yoilsho	322	28	to	to	IN
cord-006229-7yoilsho	322	29	some	some	DT
cord-006229-7yoilsho	322	30	extent	extent	NN
cord-006229-7yoilsho	322	31	of	of	IN
cord-006229-7yoilsho	322	32	the	the	DT
cord-006229-7yoilsho	322	33	corresponding	corresponding	JJ
cord-006229-7yoilsho	322	34	cytidylyl	cytidylyl	JJ
cord-006229-7yoilsho	322	35	analogue	analogue	NN
cord-006229-7yoilsho	322	36	cCMP	ccmp	NN
cord-006229-7yoilsho	322	37	1,2	1,2	CD
cord-006229-7yoilsho	322	38	.	.	.
cord-006229-7yoilsho	323	1	Currently	currently	RB
cord-006229-7yoilsho	323	2	,	,	,
cord-006229-7yoilsho	323	3	the	the	DT
cord-006229-7yoilsho	323	4	role	role	NN
cord-006229-7yoilsho	323	5	of	of	IN
cord-006229-7yoilsho	323	6	cUMP	cUMP	NNP
cord-006229-7yoilsho	323	7	and	and	CC
cord-006229-7yoilsho	323	8	cCMP	ccmp	NN
cord-006229-7yoilsho	323	9	during	during	IN
cord-006229-7yoilsho	323	10	the	the	DT
cord-006229-7yoilsho	323	11	pathogenesis	pathogenesis	NN
cord-006229-7yoilsho	323	12	of	of	IN
cord-006229-7yoilsho	323	13	P.	p.	NN
cord-006229-7yoilsho	323	14	aeruginosa	aeruginosa	NN
cord-006229-7yoilsho	323	15	infection	infection	NN
cord-006229-7yoilsho	323	16	remains	remain	VBZ
cord-006229-7yoilsho	323	17	unknown	unknown	JJ
cord-006229-7yoilsho	323	18	3	3	CD
cord-006229-7yoilsho	323	19	.	.	.
cord-006229-7yoilsho	324	1	One	one	CD
cord-006229-7yoilsho	324	2	of	of	IN
cord-006229-7yoilsho	324	3	our	-PRON-	PRP$
cord-006229-7yoilsho	324	4	hypotheses	hypothesis	NNS
cord-006229-7yoilsho	324	5	is	be	VBZ
cord-006229-7yoilsho	324	6	that	that	IN
cord-006229-7yoilsho	324	7	these	these	DT
cord-006229-7yoilsho	324	8	cyclic	cyclic	JJ
cord-006229-7yoilsho	324	9	nucleotides	nucleotide	NNS
cord-006229-7yoilsho	324	10	fulfil	fulfil	VBP
cord-006229-7yoilsho	324	11	a	a	DT
cord-006229-7yoilsho	324	12	role	role	NN
cord-006229-7yoilsho	324	13	as	as	IN
cord-006229-7yoilsho	324	14	first	first	JJ
cord-006229-7yoilsho	324	15	messengers	messenger	NNS
cord-006229-7yoilsho	324	16	,	,	,
cord-006229-7yoilsho	324	17	e.g.	e.g.	RB
cord-006229-7yoilsho	324	18	in	in	IN
cord-006229-7yoilsho	324	19	the	the	DT
cord-006229-7yoilsho	324	20	communication	communication	NN
cord-006229-7yoilsho	324	21	between	between	IN
cord-006229-7yoilsho	324	22	individual	individual	JJ
cord-006229-7yoilsho	324	23	bacteria	bacteria	NNS
cord-006229-7yoilsho	324	24	or	or	CC
cord-006229-7yoilsho	324	25	bacterial	bacterial	JJ
cord-006229-7yoilsho	324	26	populations	population	NNS
cord-006229-7yoilsho	324	27	during	during	IN
cord-006229-7yoilsho	324	28	establishment	establishment	NN
cord-006229-7yoilsho	324	29	of	of	IN
cord-006229-7yoilsho	324	30	acute	acute	JJ
cord-006229-7yoilsho	324	31	or	or	CC
cord-006229-7yoilsho	324	32	chronic	chronic	JJ
cord-006229-7yoilsho	324	33	infections	infection	NNS
cord-006229-7yoilsho	324	34	.	.	.
cord-006229-7yoilsho	325	1	To	to	TO
cord-006229-7yoilsho	325	2	test	test	VB
cord-006229-7yoilsho	325	3	this	this	DT
cord-006229-7yoilsho	325	4	hypothesis	hypothesis	NN
cord-006229-7yoilsho	325	5	,	,	,
cord-006229-7yoilsho	325	6	the	the	DT
cord-006229-7yoilsho	325	7	intra	intra	JJ
cord-006229-7yoilsho	325	8	-	-	JJ
cord-006229-7yoilsho	325	9	and	and	CC
cord-006229-7yoilsho	325	10	extrabacterial	extrabacterial	JJ
cord-006229-7yoilsho	325	11	concentrations	concentration	NNS
cord-006229-7yoilsho	325	12	of	of	IN
cord-006229-7yoilsho	325	13	cyclic	cyclic	JJ
cord-006229-7yoilsho	325	14	nucleotides	nucleotide	NNS
cord-006229-7yoilsho	325	15	were	be	VBD
cord-006229-7yoilsho	325	16	measured	measure	VBN
cord-006229-7yoilsho	325	17	via	via	IN
cord-006229-7yoilsho	325	18	HPLC	HPLC	NNP
cord-006229-7yoilsho	325	19	-	-	HYPH
cord-006229-7yoilsho	325	20	MS	MS	NNP
cord-006229-7yoilsho	325	21	/	/	SYM
cord-006229-7yoilsho	325	22	MS	MS	NNP
cord-006229-7yoilsho	325	23	at	at	IN
cord-006229-7yoilsho	325	24	different	different	JJ
cord-006229-7yoilsho	325	25	time	time	NN
cord-006229-7yoilsho	325	26	-	-	HYPH
cord-006229-7yoilsho	325	27	points	point	NNS
cord-006229-7yoilsho	325	28	in	in	IN
cord-006229-7yoilsho	325	29	liquid	liquid	JJ
cord-006229-7yoilsho	325	30	cultures	culture	NNS
cord-006229-7yoilsho	325	31	of	of	IN
cord-006229-7yoilsho	325	32	P.	p.	NN
cord-006229-7yoilsho	325	33	aeruginosa	aeruginosa	NN
cord-006229-7yoilsho	325	34	,	,	,
cord-006229-7yoilsho	325	35	either	either	CC
cord-006229-7yoilsho	325	36	in	in	IN
cord-006229-7yoilsho	325	37	a	a	DT
cord-006229-7yoilsho	325	38	complete	complete	JJ
cord-006229-7yoilsho	325	39	(	(	-LRB-
cord-006229-7yoilsho	325	40	LB	lb	NN
cord-006229-7yoilsho	325	41	medium	medium	NN
cord-006229-7yoilsho	325	42	)	)	-RRB-
cord-006229-7yoilsho	325	43	or	or	CC
cord-006229-7yoilsho	325	44	a	a	DT
cord-006229-7yoilsho	325	45	starving	starve	VBG
cord-006229-7yoilsho	325	46	medium	medium	NN
cord-006229-7yoilsho	325	47	(	(	-LRB-
cord-006229-7yoilsho	325	48	Vogel	Vogel	NNP
cord-006229-7yoilsho	325	49	-	-	HYPH
cord-006229-7yoilsho	325	50	Bonner	Bonner	NNP
cord-006229-7yoilsho	325	51	medium	medium	NN
cord-006229-7yoilsho	325	52	)	)	-RRB-
cord-006229-7yoilsho	325	53	.	.	.
cord-006229-7yoilsho	326	1	Additionally	additionally	RB
cord-006229-7yoilsho	326	2	,	,	,
cord-006229-7yoilsho	326	3	we	-PRON-	PRP
cord-006229-7yoilsho	326	4	tested	test	VBD
cord-006229-7yoilsho	326	5	if	if	IN
cord-006229-7yoilsho	326	6	supplementation	supplementation	NN
cord-006229-7yoilsho	326	7	of	of	IN
cord-006229-7yoilsho	326	8	the	the	DT
cord-006229-7yoilsho	326	9	media	medium	NNS
cord-006229-7yoilsho	326	10	with	with	IN
cord-006229-7yoilsho	326	11	extrinsic	extrinsic	JJ
cord-006229-7yoilsho	326	12	cUMP	cump	NN
cord-006229-7yoilsho	326	13	or	or	CC
cord-006229-7yoilsho	326	14	cCMP	ccmp	NN
cord-006229-7yoilsho	326	15	had	have	VBD
cord-006229-7yoilsho	326	16	an	an	DT
cord-006229-7yoilsho	326	17	effect	effect	NN
cord-006229-7yoilsho	326	18	on	on	IN
cord-006229-7yoilsho	326	19	these	these	DT
cord-006229-7yoilsho	326	20	measured	measure	VBN
cord-006229-7yoilsho	326	21	concentrations	concentration	NNS
cord-006229-7yoilsho	326	22	.	.	.
cord-006229-7yoilsho	327	1	The	the	DT
cord-006229-7yoilsho	327	2	influence	influence	NN
cord-006229-7yoilsho	327	3	of	of	IN
cord-006229-7yoilsho	327	4	extrabacterial	extrabacterial	JJ
cord-006229-7yoilsho	327	5	cyclic	cyclic	JJ
cord-006229-7yoilsho	327	6	nucleotides	nucleotide	NNS
cord-006229-7yoilsho	327	7	on	on	IN
cord-006229-7yoilsho	327	8	the	the	DT
cord-006229-7yoilsho	327	9	bacterial	bacterial	JJ
cord-006229-7yoilsho	327	10	metabolism	metabolism	NN
cord-006229-7yoilsho	327	11	and	and	CC
cord-006229-7yoilsho	327	12	homeostasis	homeostasis	NN
cord-006229-7yoilsho	327	13	was	be	VBD
cord-006229-7yoilsho	327	14	evaluated	evaluate	VBN
cord-006229-7yoilsho	327	15	with	with	IN
cord-006229-7yoilsho	327	16	a	a	DT
cord-006229-7yoilsho	327	17	microarray	microarray	NN
cord-006229-7yoilsho	327	18	of	of	IN
cord-006229-7yoilsho	327	19	bacterial	bacterial	JJ
cord-006229-7yoilsho	327	20	total	total	JJ
cord-006229-7yoilsho	327	21	cDNA	cdna	NN
cord-006229-7yoilsho	327	22	extracted	extract	VBN
cord-006229-7yoilsho	327	23	at	at	IN
cord-006229-7yoilsho	327	24	different	different	JJ
cord-006229-7yoilsho	327	25	time	time	NN
cord-006229-7yoilsho	327	26	points	point	NNS
cord-006229-7yoilsho	327	27	of	of	IN
cord-006229-7yoilsho	327	28	P.	P.	NNP
cord-006229-7yoilsho	327	29	aeruginosa	aeruginosa	NN
cord-006229-7yoilsho	327	30	liquid	liquid	JJ
cord-006229-7yoilsho	327	31	culture	culture	NN
cord-006229-7yoilsho	327	32	with	with	IN
cord-006229-7yoilsho	327	33	or	or	CC
cord-006229-7yoilsho	327	34	without	without	IN
cord-006229-7yoilsho	327	35	extrinsic	extrinsic	JJ
cord-006229-7yoilsho	327	36	cUMP/	cump/	NN
cord-006229-7yoilsho	327	37	cCMP	ccmp	NN
cord-006229-7yoilsho	327	38	.	.	.
cord-006229-7yoilsho	328	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	328	2	we	-PRON-	PRP
cord-006229-7yoilsho	328	3	investigated	investigate	VBD
cord-006229-7yoilsho	328	4	a	a	DT
cord-006229-7yoilsho	328	5	potential	potential	JJ
cord-006229-7yoilsho	328	6	function	function	NN
cord-006229-7yoilsho	328	7	of	of	IN
cord-006229-7yoilsho	328	8	the	the	DT
cord-006229-7yoilsho	328	9	cyclic	cyclic	JJ
cord-006229-7yoilsho	328	10	nucleotides	nucleotide	NNS
cord-006229-7yoilsho	328	11	in	in	IN
cord-006229-7yoilsho	328	12	biofilm	biofilm	NN
cord-006229-7yoilsho	328	13	formation	formation	NN
cord-006229-7yoilsho	328	14	.	.	.
cord-006229-7yoilsho	329	1	Cyclic	cyclic	JJ
cord-006229-7yoilsho	329	2	UMP	UMP	NNP
cord-006229-7yoilsho	329	3	and	and	CC
cord-006229-7yoilsho	329	4	cyclic	cyclic	JJ
cord-006229-7yoilsho	329	5	CMP	cmp	NN
cord-006229-7yoilsho	329	6	have	have	VBP
cord-006229-7yoilsho	329	7	differential	differential	JJ
cord-006229-7yoilsho	329	8	roles	role	NNS
cord-006229-7yoilsho	329	9	in	in	IN
cord-006229-7yoilsho	329	10	bacterial	bacterial	JJ
cord-006229-7yoilsho	329	11	metabolism	metabolism	NN
cord-006229-7yoilsho	329	12	and	and	CC
cord-006229-7yoilsho	329	13	communication	communication	NN
cord-006229-7yoilsho	329	14	.	.	.
cord-006229-7yoilsho	330	1	For	for	IN
cord-006229-7yoilsho	330	2	example	example	NN
cord-006229-7yoilsho	330	3	,	,	,
cord-006229-7yoilsho	330	4	whereas	whereas	IN
cord-006229-7yoilsho	330	5	cCMP	ccmp	NN
cord-006229-7yoilsho	330	6	is	be	VBZ
cord-006229-7yoilsho	330	7	synthesized	synthesize	VBN
cord-006229-7yoilsho	330	8	by	by	IN
cord-006229-7yoilsho	330	9	P.	P.	NNP
cord-006229-7yoilsho	330	10	aeruginosa	aeruginosa	NN
cord-006229-7yoilsho	330	11	when	when	WRB
cord-006229-7yoilsho	330	12	the	the	DT
cord-006229-7yoilsho	330	13	bacteria	bacteria	NNS
cord-006229-7yoilsho	330	14	are	be	VBP
cord-006229-7yoilsho	330	15	in	in	IN
cord-006229-7yoilsho	330	16	a	a	DT
cord-006229-7yoilsho	330	17	nutrient	nutrient	NN
cord-006229-7yoilsho	330	18	-	-	HYPH
cord-006229-7yoilsho	330	19	rich	rich	JJ
cord-006229-7yoilsho	330	20	environment	environment	NN
cord-006229-7yoilsho	330	21	,	,	,
cord-006229-7yoilsho	330	22	we	-PRON-	PRP
cord-006229-7yoilsho	330	23	could	could	MD
cord-006229-7yoilsho	330	24	not	not	RB
cord-006229-7yoilsho	330	25	detect	detect	VB
cord-006229-7yoilsho	330	26	bacterial	bacterial	JJ
cord-006229-7yoilsho	330	27	cUMP	cump	NN
cord-006229-7yoilsho	330	28	under	under	IN
cord-006229-7yoilsho	330	29	any	any	DT
cord-006229-7yoilsho	330	30	tested	test	VBN
cord-006229-7yoilsho	330	31	circumstance	circumstance	NN
cord-006229-7yoilsho	330	32	.	.	.
cord-006229-7yoilsho	331	1	In	in	IN
cord-006229-7yoilsho	331	2	our	-PRON-	PRP$
cord-006229-7yoilsho	331	3	biofilm	biofilm	NN
cord-006229-7yoilsho	331	4	formation	formation	NN
cord-006229-7yoilsho	331	5	assays	assay	NNS
cord-006229-7yoilsho	331	6	,	,	,
cord-006229-7yoilsho	331	7	only	only	RB
cord-006229-7yoilsho	331	8	cCMP	ccmp	NN
cord-006229-7yoilsho	331	9	had	have	VBD
cord-006229-7yoilsho	331	10	a	a	DT
cord-006229-7yoilsho	331	11	biofilmpromoting	biofilmpromoting	JJ
cord-006229-7yoilsho	331	12	effect	effect	NN
cord-006229-7yoilsho	331	13	,	,	,
cord-006229-7yoilsho	331	14	but	but	CC
cord-006229-7yoilsho	331	15	only	only	RB
cord-006229-7yoilsho	331	16	in	in	IN
cord-006229-7yoilsho	331	17	very	very	RB
cord-006229-7yoilsho	331	18	high	high	JJ
cord-006229-7yoilsho	331	19	concentrations	concentration	NNS
cord-006229-7yoilsho	331	20	.	.	.
cord-006229-7yoilsho	332	1	The	the	DT
cord-006229-7yoilsho	332	2	currently	currently	RB
cord-006229-7yoilsho	332	3	ongoing	ongoing	JJ
cord-006229-7yoilsho	332	4	analysis	analysis	NN
cord-006229-7yoilsho	332	5	of	of	IN
cord-006229-7yoilsho	332	6	gene	gene	NN
cord-006229-7yoilsho	332	7	expression	expression	NN
cord-006229-7yoilsho	332	8	data	datum	NNS
cord-006229-7yoilsho	332	9	in	in	IN
cord-006229-7yoilsho	332	10	the	the	DT
cord-006229-7yoilsho	332	11	presence	presence	NN
cord-006229-7yoilsho	332	12	or	or	CC
cord-006229-7yoilsho	332	13	absence	absence	NN
cord-006229-7yoilsho	332	14	of	of	IN
cord-006229-7yoilsho	332	15	cUMP	cump	NN
cord-006229-7yoilsho	332	16	may	may	MD
cord-006229-7yoilsho	332	17	reveal	reveal	VB
cord-006229-7yoilsho	332	18	a	a	DT
cord-006229-7yoilsho	332	19	role	role	NN
cord-006229-7yoilsho	332	20	of	of	IN
cord-006229-7yoilsho	332	21	this	this	DT
cord-006229-7yoilsho	332	22	cyclic	cyclic	JJ
cord-006229-7yoilsho	332	23	nucleotide	nucleotide	NN
cord-006229-7yoilsho	332	24	as	as	IN
cord-006229-7yoilsho	332	25	first	first	JJ
cord-006229-7yoilsho	332	26	messenger	messenger	NN
cord-006229-7yoilsho	332	27	,	,	,
cord-006229-7yoilsho	332	28	too	too	RB
cord-006229-7yoilsho	332	29	.	.	.
cord-006229-7yoilsho	333	1	In	in	IN
cord-006229-7yoilsho	333	2	further	further	JJ
cord-006229-7yoilsho	333	3	studies	study	NNS
cord-006229-7yoilsho	333	4	we	-PRON-	PRP
cord-006229-7yoilsho	333	5	will	will	MD
cord-006229-7yoilsho	333	6	elucidate	elucidate	VB
cord-006229-7yoilsho	333	7	the	the	DT
cord-006229-7yoilsho	333	8	signal	signal	NN
cord-006229-7yoilsho	333	9	transduction	transduction	NN
cord-006229-7yoilsho	333	10	processes	process	NNS
cord-006229-7yoilsho	333	11	underlying	underlie	VBG
cord-006229-7yoilsho	333	12	the	the	DT
cord-006229-7yoilsho	333	13	observed	observed	JJ
cord-006229-7yoilsho	333	14	cUMP	cump	NN
cord-006229-7yoilsho	333	15	/	/	SYM
cord-006229-7yoilsho	333	16	cCMP	ccmp	NN
cord-006229-7yoilsho	333	17	effects	effect	NNS
cord-006229-7yoilsho	333	18	,	,	,
cord-006229-7yoilsho	333	19	for	for	IN
cord-006229-7yoilsho	333	20	example	example	NN
cord-006229-7yoilsho	333	21	by	by	IN
cord-006229-7yoilsho	333	22	identifying	identify	VBG
cord-006229-7yoilsho	333	23	cUMP	cUMP	NNP
cord-006229-7yoilsho	333	24	and	and	CC
cord-006229-7yoilsho	333	25	cCMP	ccmp	NN
cord-006229-7yoilsho	333	26	binding	bind	VBG
cord-006229-7yoilsho	333	27	proteins	protein	NNS
cord-006229-7yoilsho	333	28	and	and	CC
cord-006229-7yoilsho	333	29	their	-PRON-	PRP$
cord-006229-7yoilsho	333	30	coupling	coupling	NN
cord-006229-7yoilsho	333	31	mechanisms	mechanism	NNS
cord-006229-7yoilsho	333	32	to	to	IN
cord-006229-7yoilsho	333	33	intracellular	intracellular	JJ
cord-006229-7yoilsho	333	34	signalling	signalling	NN
cord-006229-7yoilsho	333	35	cascades	cascade	NNS
cord-006229-7yoilsho	333	36	.	.	.
cord-006229-7yoilsho	334	1	Synapses	synapsis	NNS
cord-006229-7yoilsho	334	2	are	be	VBP
cord-006229-7yoilsho	334	3	complex	complex	JJ
cord-006229-7yoilsho	334	4	computational	computational	JJ
cord-006229-7yoilsho	334	5	platforms	platform	NNS
cord-006229-7yoilsho	334	6	that	that	WDT
cord-006229-7yoilsho	334	7	transmit	transmit	VBP
cord-006229-7yoilsho	334	8	information	information	NN
cord-006229-7yoilsho	334	9	encoded	encode	VBN
cord-006229-7yoilsho	334	10	in	in	IN
cord-006229-7yoilsho	334	11	action	action	NN
cord-006229-7yoilsho	334	12	potentials	potential	NNS
cord-006229-7yoilsho	334	13	but	but	CC
cord-006229-7yoilsho	334	14	also	also	RB
cord-006229-7yoilsho	334	15	transform	transform	VB
cord-006229-7yoilsho	334	16	their	-PRON-	PRP$
cord-006229-7yoilsho	334	17	functionality	functionality	NN
cord-006229-7yoilsho	334	18	through	through	IN
cord-006229-7yoilsho	334	19	synaptic	synaptic	JJ
cord-006229-7yoilsho	334	20	plasticity	plasticity	NN
cord-006229-7yoilsho	334	21	.	.	.
cord-006229-7yoilsho	335	1	G	g	NN
cord-006229-7yoilsho	335	2	protein	protein	NN
cord-006229-7yoilsho	335	3	-	-	HYPH
cord-006229-7yoilsho	335	4	coupled	couple	VBN
cord-006229-7yoilsho	335	5	receptors	receptor	NNS
cord-006229-7yoilsho	335	6	(	(	-LRB-
cord-006229-7yoilsho	335	7	GPCRs	gpcr	NNS
cord-006229-7yoilsho	335	8	)	)	-RRB-
cord-006229-7yoilsho	335	9	play	play	VBP
cord-006229-7yoilsho	335	10	a	a	DT
cord-006229-7yoilsho	335	11	major	major	JJ
cord-006229-7yoilsho	335	12	role	role	NN
cord-006229-7yoilsho	335	13	in	in	IN
cord-006229-7yoilsho	335	14	modulating	modulate	VBG
cord-006229-7yoilsho	335	15	the	the	DT
cord-006229-7yoilsho	335	16	strength	strength	NN
cord-006229-7yoilsho	335	17	of	of	IN
cord-006229-7yoilsho	335	18	the	the	DT
cord-006229-7yoilsho	335	19	synapses	synapsis	NNS
cord-006229-7yoilsho	335	20	via	via	IN
cord-006229-7yoilsho	335	21	the	the	DT
cord-006229-7yoilsho	335	22	second	second	JJ
cord-006229-7yoilsho	335	23	messenger	messenger	NN
cord-006229-7yoilsho	335	24	cAMP	camp	NN
cord-006229-7yoilsho	335	25	1	1	CD
cord-006229-7yoilsho	335	26	.	.	.
cord-006229-7yoilsho	336	1	However	however	RB
cord-006229-7yoilsho	336	2	the	the	DT
cord-006229-7yoilsho	336	3	spatio	spatio	JJ
cord-006229-7yoilsho	336	4	-	-	HYPH
cord-006229-7yoilsho	336	5	temporal	temporal	JJ
cord-006229-7yoilsho	336	6	dynamics	dynamic	NNS
cord-006229-7yoilsho	336	7	of	of	IN
cord-006229-7yoilsho	336	8	the	the	DT
cord-006229-7yoilsho	336	9	mode	mode	NN
cord-006229-7yoilsho	336	10	of	of	IN
cord-006229-7yoilsho	336	11	action	action	NN
cord-006229-7yoilsho	336	12	of	of	IN
cord-006229-7yoilsho	336	13	cAMP	camp	NN
cord-006229-7yoilsho	336	14	underlying	underlie	VBG
cord-006229-7yoilsho	336	15	synaptic	synaptic	JJ
cord-006229-7yoilsho	336	16	plasticity	plasticity	NN
cord-006229-7yoilsho	336	17	are	be	VBP
cord-006229-7yoilsho	336	18	still	still	RB
cord-006229-7yoilsho	336	19	controversial	controversial	JJ
cord-006229-7yoilsho	336	20	.	.	.
cord-006229-7yoilsho	337	1	The	the	DT
cord-006229-7yoilsho	337	2	role	role	NN
cord-006229-7yoilsho	337	3	of	of	IN
cord-006229-7yoilsho	337	4	this	this	DT
cord-006229-7yoilsho	337	5	study	study	NN
cord-006229-7yoilsho	337	6	was	be	VBD
cord-006229-7yoilsho	337	7	to	to	TO
cord-006229-7yoilsho	337	8	investigate	investigate	VB
cord-006229-7yoilsho	337	9	the	the	DT
cord-006229-7yoilsho	337	10	dynamics	dynamic	NNS
cord-006229-7yoilsho	337	11	of	of	IN
cord-006229-7yoilsho	337	12	cAMP	camp	NN
cord-006229-7yoilsho	337	13	signaling	signal	VBG
cord-006229-7yoilsho	337	14	at	at	IN
cord-006229-7yoilsho	337	15	the	the	DT
cord-006229-7yoilsho	337	16	Drosophila	Drosophila	NNP
cord-006229-7yoilsho	337	17	neuromuscular	neuromuscular	JJ
cord-006229-7yoilsho	337	18	junction	junction	NN
cord-006229-7yoilsho	337	19	,	,	,
cord-006229-7yoilsho	337	20	where	where	WRB
cord-006229-7yoilsho	337	21	octopamine	octopamine	NN
cord-006229-7yoilsho	337	22	binding	bind	VBG
cord-006229-7yoilsho	337	23	to	to	IN
cord-006229-7yoilsho	337	24	its	-PRON-	PRP$
cord-006229-7yoilsho	337	25	receptors	receptor	NNS
cord-006229-7yoilsho	337	26	has	have	VBZ
cord-006229-7yoilsho	337	27	been	be	VBN
cord-006229-7yoilsho	337	28	shown	show	VBN
cord-006229-7yoilsho	337	29	to	to	TO
cord-006229-7yoilsho	337	30	cause	cause	VB
cord-006229-7yoilsho	337	31	cAMP	camp	NN
cord-006229-7yoilsho	337	32	-	-	HYPH
cord-006229-7yoilsho	337	33	dependent	dependent	JJ
cord-006229-7yoilsho	337	34	synaptic	synaptic	JJ
cord-006229-7yoilsho	337	35	plasticity	plasticity	NN
cord-006229-7yoilsho	337	36	2	2	CD
cord-006229-7yoilsho	337	37	.	.	.
cord-006229-7yoilsho	338	1	For	for	IN
cord-006229-7yoilsho	338	2	this	this	DT
cord-006229-7yoilsho	338	3	purpose	purpose	NN
cord-006229-7yoilsho	338	4	,	,	,
cord-006229-7yoilsho	338	5	we	-PRON-	PRP
cord-006229-7yoilsho	338	6	generated	generate	VBD
cord-006229-7yoilsho	338	7	a	a	DT
cord-006229-7yoilsho	338	8	transgenic	transgenic	JJ
cord-006229-7yoilsho	338	9	Drosophila	Drosophila	NNP
cord-006229-7yoilsho	338	10	expressing	express	VBG
cord-006229-7yoilsho	338	11	the	the	DT
cord-006229-7yoilsho	338	12	cAMP	camp	NN
cord-006229-7yoilsho	338	13	sensor	sensor	NN
cord-006229-7yoilsho	338	14	Epac1-camps	Epac1-camps	NNP
cord-006229-7yoilsho	338	15	3	3	CD
cord-006229-7yoilsho	338	16	in	in	IN
cord-006229-7yoilsho	338	17	motor	motor	NN
cord-006229-7yoilsho	338	18	neuron	neuron	NN
cord-006229-7yoilsho	338	19	.	.	.
cord-006229-7yoilsho	339	1	This	this	DT
cord-006229-7yoilsho	339	2	allowed	allow	VBD
cord-006229-7yoilsho	339	3	us	-PRON-	PRP
cord-006229-7yoilsho	339	4	to	to	TO
cord-006229-7yoilsho	339	5	directly	directly	RB
cord-006229-7yoilsho	339	6	follow	follow	VB
cord-006229-7yoilsho	339	7	the	the	DT
cord-006229-7yoilsho	339	8	octopamine	octopamine	NN
cord-006229-7yoilsho	339	9	-	-	HYPH
cord-006229-7yoilsho	339	10	induced	induce	VBN
cord-006229-7yoilsho	339	11	cAMP	camp	NN
cord-006229-7yoilsho	339	12	signals	signal	NNS
cord-006229-7yoilsho	339	13	in	in	IN
cord-006229-7yoilsho	339	14	real	real	JJ
cord-006229-7yoilsho	339	15	time	time	NN
cord-006229-7yoilsho	339	16	by	by	IN
cord-006229-7yoilsho	339	17	fluorescence	fluorescence	NN
cord-006229-7yoilsho	339	18	resonance	resonance	NN
cord-006229-7yoilsho	339	19	energy	energy	NN
cord-006229-7yoilsho	339	20	transfer	transfer	NN
cord-006229-7yoilsho	339	21	(	(	-LRB-
cord-006229-7yoilsho	339	22	FRET	fret	NN
cord-006229-7yoilsho	339	23	)	)	-RRB-
cord-006229-7yoilsho	339	24	in	in	IN
cord-006229-7yoilsho	339	25	different	different	JJ
cord-006229-7yoilsho	339	26	compartments	compartment	NNS
cord-006229-7yoilsho	339	27	of	of	IN
cord-006229-7yoilsho	339	28	the	the	DT
cord-006229-7yoilsho	339	29	motor	motor	NN
cord-006229-7yoilsho	339	30	neuron	neuron	NN
cord-006229-7yoilsho	339	31	(	(	-LRB-
cord-006229-7yoilsho	339	32	i.e.	i.e.	FW
cord-006229-7yoilsho	339	33	cell	cell	NN
cord-006229-7yoilsho	339	34	body	body	NN
cord-006229-7yoilsho	339	35	,	,	,
cord-006229-7yoilsho	339	36	axon	axon	NN
cord-006229-7yoilsho	339	37	,	,	,
cord-006229-7yoilsho	339	38	boutons	bouton	NNS
cord-006229-7yoilsho	339	39	)	)	-RRB-
cord-006229-7yoilsho	339	40	.	.	.
cord-006229-7yoilsho	340	1	We	-PRON-	PRP
cord-006229-7yoilsho	340	2	found	find	VBD
cord-006229-7yoilsho	340	3	that	that	IN
cord-006229-7yoilsho	340	4	octopamine	octopamine	NN
cord-006229-7yoilsho	340	5	induces	induce	VBZ
cord-006229-7yoilsho	340	6	a	a	DT
cord-006229-7yoilsho	340	7	steep	steep	JJ
cord-006229-7yoilsho	340	8	cAMP	camp	NN
cord-006229-7yoilsho	340	9	gradient	gradient	NN
cord-006229-7yoilsho	340	10	from	from	IN
cord-006229-7yoilsho	340	11	the	the	DT
cord-006229-7yoilsho	340	12	synaptic	synaptic	JJ
cord-006229-7yoilsho	340	13	bouton	bouton	NNP
cord-006229-7yoilsho	340	14	(	(	-LRB-
cord-006229-7yoilsho	340	15	high	high	JJ
cord-006229-7yoilsho	340	16	cAMP	camp	NN
cord-006229-7yoilsho	340	17	)	)	-RRB-
cord-006229-7yoilsho	340	18	to	to	IN
cord-006229-7yoilsho	340	19	the	the	DT
cord-006229-7yoilsho	340	20	cell	cell	NN
cord-006229-7yoilsho	340	21	body	body	NN
cord-006229-7yoilsho	340	22	(	(	-LRB-
cord-006229-7yoilsho	340	23	low	low	JJ
cord-006229-7yoilsho	340	24	cAMP	camp	NN
cord-006229-7yoilsho	340	25	)	)	-RRB-
cord-006229-7yoilsho	340	26	,	,	,
cord-006229-7yoilsho	340	27	which	which	WDT
cord-006229-7yoilsho	340	28	was	be	VBD
cord-006229-7yoilsho	340	29	due	due	JJ
cord-006229-7yoilsho	340	30	by	by	IN
cord-006229-7yoilsho	340	31	higher	high	JJR
cord-006229-7yoilsho	340	32	PDE	pde	NN
cord-006229-7yoilsho	340	33	activity	activity	NN
cord-006229-7yoilsho	340	34	in	in	IN
cord-006229-7yoilsho	340	35	the	the	DT
cord-006229-7yoilsho	340	36	cell	cell	NN
cord-006229-7yoilsho	340	37	body	body	NN
cord-006229-7yoilsho	340	38	.	.	.
cord-006229-7yoilsho	341	1	High	high	JJ
cord-006229-7yoilsho	341	2	octopamine	octopamine	NN
cord-006229-7yoilsho	341	3	concentrations	concentration	NNS
cord-006229-7yoilsho	341	4	evoked	evoke	VBD
cord-006229-7yoilsho	341	5	a	a	DT
cord-006229-7yoilsho	341	6	response	response	NN
cord-006229-7yoilsho	341	7	also	also	RB
cord-006229-7yoilsho	341	8	in	in	IN
cord-006229-7yoilsho	341	9	the	the	DT
cord-006229-7yoilsho	341	10	soma	soma	NNP
cord-006229-7yoilsho	341	11	.	.	.
cord-006229-7yoilsho	342	1	Notably	notably	RB
cord-006229-7yoilsho	342	2	,	,	,
cord-006229-7yoilsho	342	3	these	these	DT
cord-006229-7yoilsho	342	4	signals	signal	NNS
cord-006229-7yoilsho	342	5	were	be	VBD
cord-006229-7yoilsho	342	6	independent	independent	JJ
cord-006229-7yoilsho	342	7	and	and	CC
cord-006229-7yoilsho	342	8	isolated	isolate	VBN
cord-006229-7yoilsho	342	9	form	form	NN
cord-006229-7yoilsho	342	10	each	each	DT
cord-006229-7yoilsho	342	11	other	other	JJ
cord-006229-7yoilsho	342	12	.	.	.
cord-006229-7yoilsho	343	1	Moreover	moreover	RB
cord-006229-7yoilsho	343	2	,	,	,
cord-006229-7yoilsho	343	3	application	application	NN
cord-006229-7yoilsho	343	4	of	of	IN
cord-006229-7yoilsho	343	5	octopamine	octopamine	NN
cord-006229-7yoilsho	343	6	by	by	IN
cord-006229-7yoilsho	343	7	iontophoresis	iontophoresis	NN
cord-006229-7yoilsho	343	8	to	to	IN
cord-006229-7yoilsho	343	9	single	single	JJ
cord-006229-7yoilsho	343	10	synaptic	synaptic	JJ
cord-006229-7yoilsho	343	11	boutons	bouton	NNS
cord-006229-7yoilsho	343	12	induced	induce	VBN
cord-006229-7yoilsho	343	13	bouton	bouton	NNP
cord-006229-7yoilsho	343	14	-	-	HYPH
cord-006229-7yoilsho	343	15	confined	confine	VBN
cord-006229-7yoilsho	343	16	cAMP	camp	NN
cord-006229-7yoilsho	343	17	signals	signal	NNS
cord-006229-7yoilsho	343	18	.	.	.
cord-006229-7yoilsho	344	1	These	these	DT
cord-006229-7yoilsho	344	2	data	datum	NNS
cord-006229-7yoilsho	344	3	reveal	reveal	VBP
cord-006229-7yoilsho	344	4	that	that	IN
cord-006229-7yoilsho	344	5	a	a	DT
cord-006229-7yoilsho	344	6	motor	motor	NN
cord-006229-7yoilsho	344	7	neuron	neuron	NN
cord-006229-7yoilsho	344	8	can	can	MD
cord-006229-7yoilsho	344	9	posses	posse	VBZ
cord-006229-7yoilsho	344	10	multiple	multiple	JJ
cord-006229-7yoilsho	344	11	and	and	CC
cord-006229-7yoilsho	344	12	largely	largely	RB
cord-006229-7yoilsho	344	13	independent	independent	JJ
cord-006229-7yoilsho	344	14	cAMP	camp	NN
cord-006229-7yoilsho	344	15	signaling	signal	VBG
cord-006229-7yoilsho	344	16	compartments	compartment	NNS
cord-006229-7yoilsho	344	17	,	,	,
cord-006229-7yoilsho	344	18	and	and	CC
cord-006229-7yoilsho	344	19	provide	provide	VB
cord-006229-7yoilsho	344	20	new	new	JJ
cord-006229-7yoilsho	344	21	basis	basis	NN
cord-006229-7yoilsho	344	22	to	to	TO
cord-006229-7yoilsho	344	23	explain	explain	VB
cord-006229-7yoilsho	344	24	how	how	WRB
cord-006229-7yoilsho	344	25	cAMP	camp	NN
cord-006229-7yoilsho	344	26	could	could	MD
cord-006229-7yoilsho	344	27	control	control	VB
cord-006229-7yoilsho	344	28	neurotransmission	neurotransmission	NN
cord-006229-7yoilsho	344	29	at	at	IN
cord-006229-7yoilsho	344	30	a	a	DT
cord-006229-7yoilsho	344	31	level	level	NN
cord-006229-7yoilsho	344	32	of	of	IN
cord-006229-7yoilsho	344	33	a	a	DT
cord-006229-7yoilsho	344	34	single	single	JJ
cord-006229-7yoilsho	344	35	synapse	synapse	NN
cord-006229-7yoilsho	344	36	.	.	.
cord-006229-7yoilsho	345	1	1	1	CD
cord-006229-7yoilsho	345	2	Kandel	Kandel	NNP
cord-006229-7yoilsho	345	3	,	,	,
cord-006229-7yoilsho	345	4	E.R.	E.R.	NNP
cord-006229-7yoilsho	345	5	,	,	,
cord-006229-7yoilsho	345	6	Dudai	Dudai	NNP
cord-006229-7yoilsho	345	7	,	,	,
cord-006229-7yoilsho	345	8	Y.	Y.	NNP
cord-006229-7yoilsho	345	9	&	&	CC
cord-006229-7yoilsho	345	10	Mayford	Mayford	NNP
cord-006229-7yoilsho	345	11	,	,	,
cord-006229-7yoilsho	346	1	M.R.	M.R.	NNP
cord-006229-7yoilsho	346	2	The	the	DT
cord-006229-7yoilsho	346	3	molecular	molecular	JJ
cord-006229-7yoilsho	346	4	and	and	CC
cord-006229-7yoilsho	346	5	systems	system	NNS
cord-006229-7yoilsho	346	6	biology	biology	NN
cord-006229-7yoilsho	346	7	of	of	IN
cord-006229-7yoilsho	346	8	memory	memory	NN
cord-006229-7yoilsho	346	9	.	.	.
cord-006229-7yoilsho	347	1	Cell	cell	NN
cord-006229-7yoilsho	347	2	157	157	CD
cord-006229-7yoilsho	347	3	,	,	,
cord-006229-7yoilsho	347	4	163	163	CD
cord-006229-7yoilsho	347	5	-	-	SYM
cord-006229-7yoilsho	347	6	186	186	CD
cord-006229-7yoilsho	347	7	(	(	-LRB-
cord-006229-7yoilsho	347	8	2014	2014	CD
cord-006229-7yoilsho	347	9	)	)	-RRB-
cord-006229-7yoilsho	347	10	.	.	.
cord-006229-7yoilsho	348	1	2	2	LS
cord-006229-7yoilsho	349	1	Koon	Koon	NNP
cord-006229-7yoilsho	349	2	,	,	,
cord-006229-7yoilsho	349	3	A.C.	A.C.	NNP
cord-006229-7yoilsho	349	4	,	,	,
cord-006229-7yoilsho	349	5	et	et	NNP
cord-006229-7yoilsho	349	6	al	al	NNP
cord-006229-7yoilsho	349	7	.	.	NNP
cord-006229-7yoilsho	349	8	,	,	,
cord-006229-7yoilsho	349	9	Autoregulatory	Autoregulatory	NNP
cord-006229-7yoilsho	349	10	and	and	CC
cord-006229-7yoilsho	349	11	paracrine	paracrine	JJ
cord-006229-7yoilsho	349	12	control	control	NN
cord-006229-7yoilsho	349	13	of	of	IN
cord-006229-7yoilsho	349	14	synaptic	synaptic	JJ
cord-006229-7yoilsho	349	15	and	and	CC
cord-006229-7yoilsho	349	16	behavioral	behavioral	JJ
cord-006229-7yoilsho	349	17	plasticity	plasticity	NN
cord-006229-7yoilsho	349	18	by	by	IN
cord-006229-7yoilsho	349	19	octopaminergic	octopaminergic	NN
cord-006229-7yoilsho	349	20	signaling	signal	VBG
cord-006229-7yoilsho	349	21	.	.	.
cord-006229-7yoilsho	350	1	Nat	Nat	NNP
cord-006229-7yoilsho	350	2	Neurosci	Neurosci	NNP
cord-006229-7yoilsho	350	3	.	.	.
cord-006229-7yoilsho	351	1	14	14	CD
cord-006229-7yoilsho	351	2	(	(	-LRB-
cord-006229-7yoilsho	351	3	2	2	CD
cord-006229-7yoilsho	351	4	)	)	-RRB-
cord-006229-7yoilsho	351	5	:	:	:
cord-006229-7yoilsho	352	1	p.	p.	NN
cord-006229-7yoilsho	352	2	190	190	CD
cord-006229-7yoilsho	352	3	-	-	SYM
cord-006229-7yoilsho	352	4	9	9	CD
cord-006229-7yoilsho	352	5	(	(	-LRB-
cord-006229-7yoilsho	352	6	2010	2010	CD
cord-006229-7yoilsho	352	7	)	)	-RRB-
cord-006229-7yoilsho	352	8	.	.	.
cord-006229-7yoilsho	353	1	3	3	CD
cord-006229-7yoilsho	353	2	Nikolaev	Nikolaev	NNP
cord-006229-7yoilsho	353	3	VO	VO	NNP
cord-006229-7yoilsho	353	4	,	,	,
cord-006229-7yoilsho	353	5	Bünemann	Bünemann	NNP
cord-006229-7yoilsho	353	6	M	M	NNP
cord-006229-7yoilsho	353	7	,	,	,
cord-006229-7yoilsho	353	8	Hein	Hein	NNP
cord-006229-7yoilsho	353	9	L	L	NNP
cord-006229-7yoilsho	353	10	,	,	,
cord-006229-7yoilsho	353	11	Hannawacker	Hannawacker	NNP
cord-006229-7yoilsho	353	12	A	A	NNP
cord-006229-7yoilsho	353	13	,	,	,
cord-006229-7yoilsho	353	14	Lohse	Lohse	NNP
cord-006229-7yoilsho	353	15	MJ	MJ	NNP
cord-006229-7yoilsho	353	16	Novel	Novel	NNP
cord-006229-7yoilsho	353	17	single	single	JJ
cord-006229-7yoilsho	353	18	chain	chain	NN
cord-006229-7yoilsho	353	19	cAMP	camp	NN
cord-006229-7yoilsho	353	20	sensors	sensor	NNS
cord-006229-7yoilsho	353	21	for	for	IN
cord-006229-7yoilsho	353	22	receptor	receptor	NN
cord-006229-7yoilsho	353	23	-	-	HYPH
cord-006229-7yoilsho	353	24	induced	induce	VBN
cord-006229-7yoilsho	353	25	signal	signal	NN
cord-006229-7yoilsho	353	26	propagation	propagation	NN
cord-006229-7yoilsho	353	27	.	.	.
cord-006229-7yoilsho	354	1	J.	J.	NNP
cord-006229-7yoilsho	354	2	Biol	Biol	NNP
cord-006229-7yoilsho	354	3	.	.	.
cord-006229-7yoilsho	355	1	Chem.279	Chem.279	NNP
cord-006229-7yoilsho	355	2	,	,	,
cord-006229-7yoilsho	355	3	37215	37215	CD
cord-006229-7yoilsho	355	4	-	-	SYM
cord-006229-7yoilsho	355	5	37218	37218	CD
cord-006229-7yoilsho	355	6	(	(	-LRB-
cord-006229-7yoilsho	355	7	2004	2004	CD
cord-006229-7yoilsho	355	8	)	)	-RRB-
cord-006229-7yoilsho	356	1	Cardiovascular	cardiovascular	JJ
cord-006229-7yoilsho	356	2	pharmacology	pharmacology	NN
cord-006229-7yoilsho	356	3	039	039	CD
cord-006229-7yoilsho	356	4	Hyaluronic	hyaluronic	NN
cord-006229-7yoilsho	356	5	acid	acid	NN
cord-006229-7yoilsho	356	6	deposition	deposition	NN
cord-006229-7yoilsho	356	7	determines	determine	VBZ
cord-006229-7yoilsho	356	8	engineered	engineer	VBN
cord-006229-7yoilsho	356	9	heart	heart	NN
cord-006229-7yoilsho	356	10	muscle	muscle	NN
cord-006229-7yoilsho	356	11	characteristics	characteristic	NNS
cord-006229-7yoilsho	356	12	and	and	CC
cord-006229-7yoilsho	356	13	can	can	MD
cord-006229-7yoilsho	356	14	be	be	VB
cord-006229-7yoilsho	356	15	pharmacologically	pharmacologically	RB
cord-006229-7yoilsho	356	16	targeted	target	VBN
cord-006229-7yoilsho	356	17	to	to	TO
cord-006229-7yoilsho	356	18	enhance	enhance	VB
cord-006229-7yoilsho	356	19	function	function	NN
cord-006229-7yoilsho	357	1	S.	S.	NNP
cord-006229-7yoilsho	357	2	Schlick	Schlick	NNP
cord-006229-7yoilsho	357	3	Background	Background	NNP
cord-006229-7yoilsho	357	4	:	:	:
cord-006229-7yoilsho	358	1	Engineered	engineer	VBN
cord-006229-7yoilsho	358	2	human	human	JJ
cord-006229-7yoilsho	358	3	myocardium	myocardium	NN
cord-006229-7yoilsho	358	4	(	(	-LRB-
cord-006229-7yoilsho	358	5	EHM	ehm	UH
cord-006229-7yoilsho	358	6	)	)	-RRB-
cord-006229-7yoilsho	358	7	can	can	MD
cord-006229-7yoilsho	358	8	be	be	VB
cord-006229-7yoilsho	358	9	generated	generate	VBN
cord-006229-7yoilsho	358	10	from	from	IN
cord-006229-7yoilsho	358	11	PSC	PSC	NNP
cord-006229-7yoilsho	358	12	derived	derive	VBN
cord-006229-7yoilsho	358	13	cardiomyocytes	cardiomyocyte	NNS
cord-006229-7yoilsho	358	14	(	(	-LRB-
cord-006229-7yoilsho	358	15	CMs	CMs	NNP
cord-006229-7yoilsho	358	16	)	)	-RRB-
cord-006229-7yoilsho	358	17	and	and	CC
cord-006229-7yoilsho	358	18	primary	primary	JJ
cord-006229-7yoilsho	358	19	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	358	20	suspended	suspend	VBN
cord-006229-7yoilsho	358	21	in	in	IN
cord-006229-7yoilsho	358	22	a	a	DT
cord-006229-7yoilsho	358	23	collagen	collagen	NN
cord-006229-7yoilsho	358	24	I	-PRON-	PRP
cord-006229-7yoilsho	358	25	hydrogel	hydrogel	NN
cord-006229-7yoilsho	358	26	(	(	-LRB-
cord-006229-7yoilsho	358	27	70%:30%:0.4	70%:30%:0.4	CD
cord-006229-7yoilsho	358	28	mg	mg	NNP
cord-006229-7yoilsho	358	29	/	/	SYM
cord-006229-7yoilsho	358	30	ml	ml	NNP
cord-006229-7yoilsho	358	31	)	)	-RRB-
cord-006229-7yoilsho	358	32	.	.	.
cord-006229-7yoilsho	359	1	EHM	ehm	UH
cord-006229-7yoilsho	359	2	development	development	NN
cord-006229-7yoilsho	359	3	encompasses	encompass	VBZ
cord-006229-7yoilsho	359	4	an	an	DT
cord-006229-7yoilsho	359	5	early	early	JJ
cord-006229-7yoilsho	359	6	consolidation	consolidation	NN
cord-006229-7yoilsho	359	7	phase	phase	NN
cord-006229-7yoilsho	359	8	followed	follow	VBN
cord-006229-7yoilsho	359	9	by	by	IN
cord-006229-7yoilsho	359	10	functional	functional	JJ
cord-006229-7yoilsho	359	11	maturation	maturation	NN
cord-006229-7yoilsho	359	12	.	.	.
cord-006229-7yoilsho	360	1	The	the	DT
cord-006229-7yoilsho	360	2	presence	presence	NN
cord-006229-7yoilsho	360	3	of	of	IN
cord-006229-7yoilsho	360	4	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	360	5	is	be	VBZ
cord-006229-7yoilsho	360	6	essential	essential	JJ
cord-006229-7yoilsho	360	7	for	for	IN
cord-006229-7yoilsho	360	8	consolidation	consolidation	NN
cord-006229-7yoilsho	360	9	into	into	IN
cord-006229-7yoilsho	360	10	a	a	DT
cord-006229-7yoilsho	360	11	force	force	NN
cord-006229-7yoilsho	360	12	-	-	HYPH
cord-006229-7yoilsho	360	13	generating	generate	VBG
cord-006229-7yoilsho	360	14	EHM	ehm	UH
cord-006229-7yoilsho	360	15	.	.	.
cord-006229-7yoilsho	361	1	Here	here	RB
cord-006229-7yoilsho	361	2	we	-PRON-	PRP
cord-006229-7yoilsho	361	3	assessed	assess	VBD
cord-006229-7yoilsho	361	4	the	the	DT
cord-006229-7yoilsho	361	5	hypothesis	hypothesis	NN
cord-006229-7yoilsho	361	6	that	that	IN
cord-006229-7yoilsho	361	7	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	361	8	of	of	IN
cord-006229-7yoilsho	361	9	different	different	JJ
cord-006229-7yoilsho	361	10	origin	origin	NN
cord-006229-7yoilsho	361	11	support	support	NN
cord-006229-7yoilsho	361	12	EHM	EHM	NNP
cord-006229-7yoilsho	361	13	formation	formation	NN
cord-006229-7yoilsho	361	14	differentially	differentially	RB
cord-006229-7yoilsho	361	15	as	as	IN
cord-006229-7yoilsho	361	16	a	a	DT
cord-006229-7yoilsho	361	17	function	function	NN
cord-006229-7yoilsho	361	18	of	of	IN
cord-006229-7yoilsho	361	19	hyaluronic	hyaluronic	NN
cord-006229-7yoilsho	361	20	acid	acid	NN
cord-006229-7yoilsho	361	21	deposition	deposition	NN
cord-006229-7yoilsho	361	22	.	.	.
cord-006229-7yoilsho	362	1	Methods	method	NNS
cord-006229-7yoilsho	362	2	and	and	CC
cord-006229-7yoilsho	362	3	results	result	NNS
cord-006229-7yoilsho	362	4	:	:	:
cord-006229-7yoilsho	362	5	Oscillatory	oscillatory	NN
cord-006229-7yoilsho	362	6	rheology	rheology	NN
cord-006229-7yoilsho	362	7	(	(	-LRB-
cord-006229-7yoilsho	362	8	1	1	CD
cord-006229-7yoilsho	362	9	%	%	NN
cord-006229-7yoilsho	362	10	strain	strain	NN
cord-006229-7yoilsho	362	11	,	,	,
cord-006229-7yoilsho	362	12	1	1	CD
cord-006229-7yoilsho	362	13	Hz	Hz	NNP
cord-006229-7yoilsho	362	14	)	)	-RRB-
cord-006229-7yoilsho	362	15	on	on	IN
cord-006229-7yoilsho	362	16	cell	cell	NN
cord-006229-7yoilsho	362	17	-	-	HYPH
cord-006229-7yoilsho	362	18	free	free	JJ
cord-006229-7yoilsho	362	19	and	and	CC
cord-006229-7yoilsho	362	20	cell	cell	NN
cord-006229-7yoilsho	362	21	containing	contain	VBG
cord-006229-7yoilsho	362	22	collagen	collagen	NN
cord-006229-7yoilsho	362	23	I	-PRON-	PRP
cord-006229-7yoilsho	362	24	hydrogels	hydrogel	NNS
cord-006229-7yoilsho	362	25	directly	directly	RB
cord-006229-7yoilsho	362	26	after	after	IN
cord-006229-7yoilsho	362	27	casting	cast	VBG
cord-006229-7yoilsho	362	28	revealed	reveal	VBD
cord-006229-7yoilsho	362	29	enhanced	enhanced	JJ
cord-006229-7yoilsho	362	30	consolidation	consolidation	NN
cord-006229-7yoilsho	362	31	in	in	IN
cord-006229-7yoilsho	362	32	the	the	DT
cord-006229-7yoilsho	362	33	presence	presence	NN
cord-006229-7yoilsho	362	34	of	of	IN
cord-006229-7yoilsho	362	35	human	human	JJ
cord-006229-7yoilsho	362	36	foreskin	foreskin	NN
cord-006229-7yoilsho	362	37	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	362	38	(	(	-LRB-
cord-006229-7yoilsho	362	39	FFBs	FFBs	NNP
cord-006229-7yoilsho	362	40	)	)	-RRB-
cord-006229-7yoilsho	362	41	compared	compare	VBN
cord-006229-7yoilsho	362	42	to	to	IN
cord-006229-7yoilsho	362	43	primary	primary	JJ
cord-006229-7yoilsho	362	44	adult	adult	NN
cord-006229-7yoilsho	362	45	cardiac	cardiac	JJ
cord-006229-7yoilsho	362	46	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	362	47	(	(	-LRB-
cord-006229-7yoilsho	362	48	CFBs	CFBs	NNP
cord-006229-7yoilsho	362	49	)	)	-RRB-
cord-006229-7yoilsho	363	1	-change	-change	JJ
cord-006229-7yoilsho	364	1	in	in	IN
cord-006229-7yoilsho	364	2	storage	storage	NN
cord-006229-7yoilsho	364	3	modulus	modulus	NN
cord-006229-7yoilsho	364	4	over	over	IN
cord-006229-7yoilsho	364	5	time	time	NN
cord-006229-7yoilsho	364	6	(	(	-LRB-
cord-006229-7yoilsho	364	7	Pa	Pa	NNP
cord-006229-7yoilsho	364	8	/	/	SYM
cord-006229-7yoilsho	364	9	min	min	NNP
cord-006229-7yoilsho	364	10	)	)	-RRB-
cord-006229-7yoilsho	364	11	:	:	:
cord-006229-7yoilsho	364	12	collagen	collagen	NN
cord-006229-7yoilsho	364	13	0.03	0.03	CD
cord-006229-7yoilsho	364	14	;	;	:
cord-006229-7yoilsho	365	1	collagen	collagen	NNP
cord-006229-7yoilsho	365	2	+	+	CC
cord-006229-7yoilsho	365	3	CMs	CMs	NNP
cord-006229-7yoilsho	365	4	0.03	0.03	CD
cord-006229-7yoilsho	365	5	;	;	:
cord-006229-7yoilsho	365	6	collagen	collagen	NNP
cord-006229-7yoilsho	365	7	+	+	CC
cord-006229-7yoilsho	365	8	CMs	CMs	NNP
cord-006229-7yoilsho	365	9	+	+	SYM
cord-006229-7yoilsho	365	10	CFBs	CFBs	NNP
cord-006229-7yoilsho	365	11	0.09	0.09	CD
cord-006229-7yoilsho	365	12	,	,	,
cord-006229-7yoilsho	365	13	collagen	collagen	NNP
cord-006229-7yoilsho	365	14	+	+	CC
cord-006229-7yoilsho	365	15	CMs	cms	NN
cord-006229-7yoilsho	365	16	+	+	CC
cord-006229-7yoilsho	365	17	FFBs	FFBs	NNP
cord-006229-7yoilsho	365	18	0.2	0.2	CD
cord-006229-7yoilsho	365	19	.	.	.
cord-006229-7yoilsho	366	1	We	-PRON-	PRP
cord-006229-7yoilsho	366	2	next	next	RB
cord-006229-7yoilsho	366	3	generated	generate	VBD
cord-006229-7yoilsho	366	4	EHM	ehm	UH
cord-006229-7yoilsho	366	5	with	with	IN
cord-006229-7yoilsho	366	6	CMs	cm	NNS
cord-006229-7yoilsho	366	7	and	and	CC
cord-006229-7yoilsho	366	8	FFBs	FFBs	NNP
cord-006229-7yoilsho	366	9	or	or	CC
cord-006229-7yoilsho	366	10	CFBs	CFBs	NNP
cord-006229-7yoilsho	366	11	.	.	.
cord-006229-7yoilsho	367	1	After	after	IN
cord-006229-7yoilsho	367	2	4	4	CD
cord-006229-7yoilsho	367	3	weeks	week	NNS
cord-006229-7yoilsho	367	4	of	of	IN
cord-006229-7yoilsho	367	5	culture	culture	NN
cord-006229-7yoilsho	367	6	under	under	IN
cord-006229-7yoilsho	367	7	serum	serum	NN
cord-006229-7yoilsho	367	8	-	-	HYPH
cord-006229-7yoilsho	367	9	free	free	JJ
cord-006229-7yoilsho	367	10	conditions	condition	NNS
cord-006229-7yoilsho	367	11	,	,	,
cord-006229-7yoilsho	367	12	we	-PRON-	PRP
cord-006229-7yoilsho	367	13	assessed	assess	VBD
cord-006229-7yoilsho	367	14	EHM	ehm	UH
cord-006229-7yoilsho	367	15	function	function	NN
cord-006229-7yoilsho	367	16	by	by	IN
cord-006229-7yoilsho	367	17	contraction	contraction	NN
cord-006229-7yoilsho	367	18	measurements	measurement	NNS
cord-006229-7yoilsho	367	19	.	.	.
cord-006229-7yoilsho	368	1	FFB	FFB	NNP
cord-006229-7yoilsho	368	2	-	-	HYPH
cord-006229-7yoilsho	368	3	EHMs	EHMs	NNP
cord-006229-7yoilsho	368	4	developed	develop	VBD
cord-006229-7yoilsho	368	5	a	a	DT
cord-006229-7yoilsho	368	6	significantly	significantly	RB
cord-006229-7yoilsho	368	7	(	(	-LRB-
cord-006229-7yoilsho	368	8	p<0.01	p<0.01	NNP
cord-006229-7yoilsho	368	9	)	)	-RRB-
cord-006229-7yoilsho	368	10	higher	high	JJR
cord-006229-7yoilsho	368	11	force	force	NN
cord-006229-7yoilsho	368	12	of	of	IN
cord-006229-7yoilsho	368	13	contraction	contraction	NN
cord-006229-7yoilsho	368	14	(	(	-LRB-
cord-006229-7yoilsho	368	15	FOC	FOC	NNP
cord-006229-7yoilsho	368	16	)	)	-RRB-
cord-006229-7yoilsho	368	17	per	per	IN
cord-006229-7yoilsho	368	18	cross	cross	JJ
cord-006229-7yoilsho	368	19	sectional	sectional	JJ
cord-006229-7yoilsho	368	20	area	area	NN
cord-006229-7yoilsho	368	21	(	(	-LRB-
cord-006229-7yoilsho	368	22	CSA	CSA	NNP
cord-006229-7yoilsho	368	23	)	)	-RRB-
cord-006229-7yoilsho	368	24	than	than	IN
cord-006229-7yoilsho	368	25	CFB	CFB	NNP
cord-006229-7yoilsho	368	26	-	-	HYPH
cord-006229-7yoilsho	368	27	EHMs	EHMs	NNP
cord-006229-7yoilsho	368	28	(	(	-LRB-
cord-006229-7yoilsho	368	29	maximal	maximal	JJ
cord-006229-7yoilsho	368	30	FOC/	FOC/	NNP
cord-006229-7yoilsho	368	31	CSA	CSA	NNP
cord-006229-7yoilsho	368	32	are	be	VBP
cord-006229-7yoilsho	368	33	in	in	IN
cord-006229-7yoilsho	368	34	mN	mN	NNP
cord-006229-7yoilsho	368	35	/	/	SYM
cord-006229-7yoilsho	368	36	mm	mm	NNP
cord-006229-7yoilsho	368	37	2	2	CD
cord-006229-7yoilsho	368	38	:	:	:
cord-006229-7yoilsho	368	39	1.8±0.1	1.8±0.1	CD
cord-006229-7yoilsho	368	40	,	,	,
cord-006229-7yoilsho	368	41	n=29	n=29	JJ
cord-006229-7yoilsho	368	42	vs.	vs.	IN
cord-006229-7yoilsho	368	43	0.3±0.1	0.3±0.1	CD
cord-006229-7yoilsho	368	44	,	,	,
cord-006229-7yoilsho	368	45	n=20	n=20	NNP
cord-006229-7yoilsho	368	46	)	)	-RRB-
cord-006229-7yoilsho	368	47	.	.	.
cord-006229-7yoilsho	369	1	Cross	Cross	NNP
cord-006229-7yoilsho	369	2	sectional	sectional	JJ
cord-006229-7yoilsho	369	3	area	area	NN
cord-006229-7yoilsho	369	4	(	(	-LRB-
cord-006229-7yoilsho	369	5	CSA	CSA	NNP
cord-006229-7yoilsho	369	6	)	)	-RRB-
cord-006229-7yoilsho	369	7	of	of	IN
cord-006229-7yoilsho	369	8	tissues	tissue	NNS
cord-006229-7yoilsho	369	9	was	be	VBD
cord-006229-7yoilsho	369	10	greatly	greatly	RB
cord-006229-7yoilsho	369	11	increased	increase	VBN
cord-006229-7yoilsho	369	12	(	(	-LRB-
cord-006229-7yoilsho	369	13	p<0.01	p<0.01	NNP
cord-006229-7yoilsho	369	14	)	)	-RRB-
cord-006229-7yoilsho	369	15	in	in	IN
cord-006229-7yoilsho	369	16	CFB	CFB	NNP
cord-006229-7yoilsho	369	17	-	-	HYPH
cord-006229-7yoilsho	369	18	EHMs	EHMs	NNP
cord-006229-7yoilsho	369	19	(	(	-LRB-
cord-006229-7yoilsho	369	20	CSA	CSA	NNP
cord-006229-7yoilsho	369	21	in	in	IN
cord-006229-7yoilsho	369	22	mm	mm	NNP
cord-006229-7yoilsho	369	23	2	2	CD
cord-006229-7yoilsho	369	24	:	:	:
cord-006229-7yoilsho	369	25	1.6±0.1	1.6±0.1	CD
cord-006229-7yoilsho	369	26	,	,	,
cord-006229-7yoilsho	369	27	n=20	n=20	NN
cord-006229-7yoilsho	369	28	vs.	vs.	IN
cord-006229-7yoilsho	369	29	0.6±0.03	0.6±0.03	NNP
cord-006229-7yoilsho	369	30	,	,	,
cord-006229-7yoilsho	369	31	n=30	n=30	NNP
cord-006229-7yoilsho	369	32	)	)	-RRB-
cord-006229-7yoilsho	369	33	and	and	CC
cord-006229-7yoilsho	369	34	nonmyocyte	nonmyocyte	NN
cord-006229-7yoilsho	369	35	content	content	NN
cord-006229-7yoilsho	369	36	was	be	VBD
cord-006229-7yoilsho	369	37	higher	high	JJR
cord-006229-7yoilsho	369	38	in	in	IN
cord-006229-7yoilsho	369	39	CFB	CFB	NNP
cord-006229-7yoilsho	369	40	-	-	HYPH
cord-006229-7yoilsho	369	41	EHMs	EHMs	NNP
cord-006229-7yoilsho	369	42	(	(	-LRB-
cord-006229-7yoilsho	369	43	5.6±0.7	5.6±0.7	NNP
cord-006229-7yoilsho	369	44	,	,	,
cord-006229-7yoilsho	369	45	n=9	n=9	NN
cord-006229-7yoilsho	369	46	vs.	vs.	FW
cord-006229-7yoilsho	369	47	3.1±0.4	3.1±0.4	NNP
cord-006229-7yoilsho	369	48	,	,	,
cord-006229-7yoilsho	369	49	n=15	n=15	NN
cord-006229-7yoilsho	369	50	;	;	:
cord-006229-7yoilsho	369	51	x10	x10	CD
cord-006229-7yoilsho	369	52	5	5	CD
cord-006229-7yoilsho	369	53	cells	cell	NNS
cord-006229-7yoilsho	369	54	/	/	SYM
cord-006229-7yoilsho	369	55	ml	ml	NN
cord-006229-7yoilsho	369	56	)	)	-RRB-
cord-006229-7yoilsho	369	57	.	.	.
cord-006229-7yoilsho	370	1	Histological	Histological	NNP
cord-006229-7yoilsho	370	2	analysis	analysis	NN
cord-006229-7yoilsho	370	3	revealed	reveal	VBD
cord-006229-7yoilsho	370	4	that	that	IN
cord-006229-7yoilsho	370	5	cardiomyocytes	cardiomyocyte	NNS
cord-006229-7yoilsho	370	6	were	be	VBD
cord-006229-7yoilsho	370	7	only	only	RB
cord-006229-7yoilsho	370	8	poorly	poorly	RB
cord-006229-7yoilsho	370	9	matured	mature	VBN
cord-006229-7yoilsho	370	10	in	in	IN
cord-006229-7yoilsho	370	11	CFB	CFB	NNP
cord-006229-7yoilsho	370	12	-	-	HYPH
cord-006229-7yoilsho	370	13	EHMs	EHMs	NNP
cord-006229-7yoilsho	370	14	compared	compare	VBN
cord-006229-7yoilsho	370	15	to	to	IN
cord-006229-7yoilsho	370	16	FFB	FFB	NNP
cord-006229-7yoilsho	370	17	-	-	HYPH
cord-006229-7yoilsho	370	18	EHMS	EHMS	NNP
cord-006229-7yoilsho	370	19	.	.	.
cord-006229-7yoilsho	371	1	Extending	extend	VBG
cord-006229-7yoilsho	371	2	EHM	ehm	UH
cord-006229-7yoilsho	371	3	functional	functional	JJ
cord-006229-7yoilsho	371	4	data	datum	NNS
cord-006229-7yoilsho	371	5	,	,	,
cord-006229-7yoilsho	371	6	principal	principal	JJ
cord-006229-7yoilsho	371	7	component	component	NN
cord-006229-7yoilsho	371	8	analysis	analysis	NN
cord-006229-7yoilsho	371	9	of	of	IN
cord-006229-7yoilsho	371	10	RNAseq	RNAseq	NNP
cord-006229-7yoilsho	371	11	data	datum	NNS
cord-006229-7yoilsho	371	12	revealed	reveal	VBD
cord-006229-7yoilsho	371	13	distinct	distinct	JJ
cord-006229-7yoilsho	371	14	expression	expression	NN
cord-006229-7yoilsho	371	15	patterns	pattern	NNS
cord-006229-7yoilsho	371	16	for	for	IN
cord-006229-7yoilsho	371	17	FFBs	ffb	NNS
cord-006229-7yoilsho	371	18	and	and	CC
cord-006229-7yoilsho	371	19	CFBs	CFBs	NNP
cord-006229-7yoilsho	371	20	,	,	,
cord-006229-7yoilsho	371	21	in	in	IN
cord-006229-7yoilsho	371	22	which	which	WDT
cord-006229-7yoilsho	371	23	hyaluronic	hyaluronic	NN
cord-006229-7yoilsho	371	24	acid	acid	NN
cord-006229-7yoilsho	371	25	synthase	synthase	NN
cord-006229-7yoilsho	371	26	2	2	CD
cord-006229-7yoilsho	372	1	(	(	-LRB-
cord-006229-7yoilsho	372	2	HAS2	HAS2	NNP
cord-006229-7yoilsho	372	3	)	)	-RRB-
cord-006229-7yoilsho	372	4	enzyme	enzyme	NN
cord-006229-7yoilsho	372	5	was	be	VBD
cord-006229-7yoilsho	372	6	significantly	significantly	RB
cord-006229-7yoilsho	372	7	(	(	-LRB-
cord-006229-7yoilsho	372	8	p<0.01	p<0.01	NN
cord-006229-7yoilsho	372	9	)	)	-RRB-
cord-006229-7yoilsho	372	10	upregulated	upregulate	VBN
cord-006229-7yoilsho	372	11	.	.	.
cord-006229-7yoilsho	373	1	Based	base	VBN
cord-006229-7yoilsho	373	2	on	on	IN
cord-006229-7yoilsho	373	3	these	these	DT
cord-006229-7yoilsho	373	4	findings	finding	NNS
cord-006229-7yoilsho	373	5	,	,	,
cord-006229-7yoilsho	373	6	we	-PRON-	PRP
cord-006229-7yoilsho	373	7	pharmacologically	pharmacologically	RB
cord-006229-7yoilsho	373	8	intervened	intervene	VBD
cord-006229-7yoilsho	373	9	with	with	IN
cord-006229-7yoilsho	373	10	HAS2	HAS2	NNP
cord-006229-7yoilsho	373	11	mediated	mediate	VBN
cord-006229-7yoilsho	373	12	hyaluronic	hyaluronic	NN
cord-006229-7yoilsho	373	13	acid	acid	NN
cord-006229-7yoilsho	373	14	(	(	-LRB-
cord-006229-7yoilsho	373	15	HA	HA	NNP
cord-006229-7yoilsho	373	16	)	)	-RRB-
cord-006229-7yoilsho	373	17	deposition	deposition	NN
cord-006229-7yoilsho	373	18	by	by	IN
cord-006229-7yoilsho	373	19	treating	treat	VBG
cord-006229-7yoilsho	373	20	CFB	CFB	NNP
cord-006229-7yoilsho	373	21	-	-	HYPH
cord-006229-7yoilsho	373	22	EHMs	EHMs	NNP
cord-006229-7yoilsho	373	23	with	with	IN
cord-006229-7yoilsho	373	24	hyaluronidase	hyaluronidase	NN
cord-006229-7yoilsho	373	25	during	during	IN
cord-006229-7yoilsho	373	26	all	all	DT
cord-006229-7yoilsho	373	27	4	4	CD
cord-006229-7yoilsho	373	28	weeks	week	NNS
cord-006229-7yoilsho	373	29	of	of	IN
cord-006229-7yoilsho	373	30	culture	culture	NN
cord-006229-7yoilsho	373	31	.	.	.
cord-006229-7yoilsho	374	1	Interestingly	interestingly	RB
cord-006229-7yoilsho	374	2	,	,	,
cord-006229-7yoilsho	374	3	ECM	ECM	NNP
cord-006229-7yoilsho	374	4	manipulation	manipulation	NN
cord-006229-7yoilsho	374	5	with	with	IN
cord-006229-7yoilsho	374	6	low	low	JJ
cord-006229-7yoilsho	374	7	concentrations	concentration	NNS
cord-006229-7yoilsho	374	8	of	of	IN
cord-006229-7yoilsho	374	9	enzyme	enzyme	NN
cord-006229-7yoilsho	374	10	significantly	significantly	RB
cord-006229-7yoilsho	374	11	(	(	-LRB-
cord-006229-7yoilsho	374	12	p<0.01	p<0.01	NNP
cord-006229-7yoilsho	374	13	)	)	-RRB-
cord-006229-7yoilsho	374	14	reduced	reduce	VBD
cord-006229-7yoilsho	374	15	CSA	CSA	NNP
cord-006229-7yoilsho	374	16	(	(	-LRB-
cord-006229-7yoilsho	374	17	CSA	CSA	NNP
cord-006229-7yoilsho	374	18	in	in	IN
cord-006229-7yoilsho	374	19	mm	mm	NNP
cord-006229-7yoilsho	374	20	2	2	CD
cord-006229-7yoilsho	374	21	:	:	:
cord-006229-7yoilsho	374	22	control	control	NNP
cord-006229-7yoilsho	374	23	1.8±0.4	1.8±0.4	CD
cord-006229-7yoilsho	374	24	,	,	,
cord-006229-7yoilsho	374	25	n=8	n=8	NN
cord-006229-7yoilsho	374	26	;	;	:
cord-006229-7yoilsho	374	27	hyaluronidase	hyaluronidase	NN
cord-006229-7yoilsho	374	28	of	of	IN
cord-006229-7yoilsho	374	29	concentrations	concentration	NNS
cord-006229-7yoilsho	374	30	from	from	IN
cord-006229-7yoilsho	374	31	0.15U	0.15u	CD
cord-006229-7yoilsho	374	32	to	to	IN
cord-006229-7yoilsho	374	33	150U	150u	CD
cord-006229-7yoilsho	374	34	0.9±0.2	0.9±0.2	CD
cord-006229-7yoilsho	374	35	,	,	,
cord-006229-7yoilsho	374	36	n=4	n=4	NNS
cord-006229-7yoilsho	374	37	)	)	-RRB-
cord-006229-7yoilsho	374	38	with	with	IN
cord-006229-7yoilsho	374	39	a	a	DT
cord-006229-7yoilsho	374	40	concurrent	concurrent	JJ
cord-006229-7yoilsho	374	41	,	,	,
cord-006229-7yoilsho	374	42	statistically	statistically	RB
cord-006229-7yoilsho	374	43	significant	significant	JJ
cord-006229-7yoilsho	374	44	(	(	-LRB-
cord-006229-7yoilsho	374	45	p<0.01	p<0.01	NNP
cord-006229-7yoilsho	374	46	)	)	-RRB-
cord-006229-7yoilsho	374	47	,	,	,
cord-006229-7yoilsho	374	48	increase	increase	NN
cord-006229-7yoilsho	374	49	in	in	IN
cord-006229-7yoilsho	374	50	contractile	contractile	JJ
cord-006229-7yoilsho	374	51	function	function	NN
cord-006229-7yoilsho	374	52	and	and	CC
cord-006229-7yoilsho	374	53	improved	improve	VBD
cord-006229-7yoilsho	374	54	cardiomyocyte	cardiomyocyte	NNP
cord-006229-7yoilsho	374	55	morphology	morphology	NN
cord-006229-7yoilsho	374	56	on	on	IN
cord-006229-7yoilsho	374	57	a	a	DT
cord-006229-7yoilsho	374	58	histological	histological	JJ
cord-006229-7yoilsho	374	59	level	level	NN
cord-006229-7yoilsho	374	60	(	(	-LRB-
cord-006229-7yoilsho	374	61	maximal	maximal	JJ
cord-006229-7yoilsho	374	62	FOC	FOC	NNP
cord-006229-7yoilsho	374	63	/	/	SYM
cord-006229-7yoilsho	374	64	CSA	CSA	NNP
cord-006229-7yoilsho	374	65	in	in	IN
cord-006229-7yoilsho	374	66	mN	mN	NNP
cord-006229-7yoilsho	374	67	/	/	SYM
cord-006229-7yoilsho	374	68	mm	mm	NNP
cord-006229-7yoilsho	374	69	2	2	CD
cord-006229-7yoilsho	374	70	:	:	:
cord-006229-7yoilsho	374	71	control	control	VB
cord-006229-7yoilsho	374	72	0.2±0.05	0.2±0.05	CD
cord-006229-7yoilsho	374	73	,	,	,
cord-006229-7yoilsho	374	74	n=8	n=8	NN
cord-006229-7yoilsho	374	75	;	;	,
cord-006229-7yoilsho	374	76	hyaluronidase	hyaluronidase	NN
cord-006229-7yoilsho	374	77	of	of	IN
cord-006229-7yoilsho	374	78	concentrations	concentration	NNS
cord-006229-7yoilsho	374	79	from	from	IN
cord-006229-7yoilsho	374	80	0.15U	0.15u	CD
cord-006229-7yoilsho	374	81	to	to	IN
cord-006229-7yoilsho	374	82	150U	150u	CD
cord-006229-7yoilsho	374	83	0.4±0.08	0.4±0.08	CD
cord-006229-7yoilsho	374	84	,	,	,
cord-006229-7yoilsho	374	85	n=4	n=4	JJ
cord-006229-7yoilsho	374	86	)	)	-RRB-
cord-006229-7yoilsho	374	87	.	.	.
cord-006229-7yoilsho	375	1	Summary	summary	NN
cord-006229-7yoilsho	375	2	and	and	CC
cord-006229-7yoilsho	375	3	conclusions	conclusion	NNS
cord-006229-7yoilsho	375	4	:	:	:
cord-006229-7yoilsho	375	5	Our	-PRON-	PRP$
cord-006229-7yoilsho	375	6	data	datum	NNS
cord-006229-7yoilsho	375	7	suggest	suggest	VBP
cord-006229-7yoilsho	375	8	that	that	IN
cord-006229-7yoilsho	375	9	EHM	EHM	NNP
cord-006229-7yoilsho	375	10	consolidation	consolidation	NN
cord-006229-7yoilsho	375	11	is	be	VBZ
cord-006229-7yoilsho	375	12	influenced	influence	VBN
cord-006229-7yoilsho	375	13	differentially	differentially	RB
cord-006229-7yoilsho	375	14	by	by	IN
cord-006229-7yoilsho	375	15	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	375	16	of	of	IN
cord-006229-7yoilsho	375	17	different	different	JJ
cord-006229-7yoilsho	375	18	tissue	tissue	NN
cord-006229-7yoilsho	375	19	origin	origin	NN
cord-006229-7yoilsho	375	20	with	with	IN
cord-006229-7yoilsho	376	1	HFF	HFF	NNP
cord-006229-7yoilsho	376	2	-	-	HYPH
cord-006229-7yoilsho	376	3	EHM	EHM	NNP
cord-006229-7yoilsho	376	4	being	be	VBG
cord-006229-7yoilsho	376	5	functionally	functionally	RB
cord-006229-7yoilsho	376	6	superior	superior	JJ
cord-006229-7yoilsho	376	7	to	to	IN
cord-006229-7yoilsho	376	8	CFB	CFB	NNP
cord-006229-7yoilsho	376	9	-	-	HYPH
cord-006229-7yoilsho	376	10	EHM	EHM	NNP
cord-006229-7yoilsho	376	11	.	.	.
cord-006229-7yoilsho	377	1	CFB	CFB	NNP
cord-006229-7yoilsho	377	2	-	-	HYPH
cord-006229-7yoilsho	377	3	EHM	EHM	NNP
cord-006229-7yoilsho	377	4	could	could	MD
cord-006229-7yoilsho	377	5	be	be	VB
cord-006229-7yoilsho	377	6	rescued	rescue	VBN
cord-006229-7yoilsho	377	7	by	by	IN
cord-006229-7yoilsho	377	8	hyaluronidase	hyaluronidase	NN
cord-006229-7yoilsho	377	9	leading	lead	VBG
cord-006229-7yoilsho	377	10	to	to	IN
cord-006229-7yoilsho	377	11	reduced	reduce	VBN
cord-006229-7yoilsho	377	12	HA	HA	NNP
cord-006229-7yoilsho	377	13	deposition	deposition	NN
cord-006229-7yoilsho	377	14	.	.	.
cord-006229-7yoilsho	378	1	The	the	DT
cord-006229-7yoilsho	378	2	latter	latter	NN
cord-006229-7yoilsho	378	3	demonstrates	demonstrate	VBZ
cord-006229-7yoilsho	378	4	that	that	IN
cord-006229-7yoilsho	378	5	extracellular	extracellular	JJ
cord-006229-7yoilsho	378	6	matrix	matrix	NN
cord-006229-7yoilsho	378	7	composition	composition	NN
cord-006229-7yoilsho	378	8	is	be	VBZ
cord-006229-7yoilsho	378	9	centrally	centrally	RB
cord-006229-7yoilsho	378	10	involved	involve	VBN
cord-006229-7yoilsho	378	11	in	in	IN
cord-006229-7yoilsho	378	12	EHM	EHM	NNP
cord-006229-7yoilsho	378	13	development	development	NN
cord-006229-7yoilsho	378	14	.	.	.
cord-006229-7yoilsho	379	1	Angiogenesis	angiogenesis	NN
cord-006229-7yoilsho	379	2	is	be	VBZ
cord-006229-7yoilsho	379	3	the	the	DT
cord-006229-7yoilsho	379	4	process	process	NN
cord-006229-7yoilsho	379	5	of	of	IN
cord-006229-7yoilsho	379	6	formation	formation	NN
cord-006229-7yoilsho	379	7	of	of	IN
cord-006229-7yoilsho	379	8	new	new	JJ
cord-006229-7yoilsho	379	9	blood	blood	NN
cord-006229-7yoilsho	379	10	vessels	vessel	NNS
cord-006229-7yoilsho	379	11	from	from	IN
cord-006229-7yoilsho	379	12	the	the	DT
cord-006229-7yoilsho	379	13	pre	pre	JJ
cord-006229-7yoilsho	379	14	-	-	JJ
cord-006229-7yoilsho	379	15	existing	existing	JJ
cord-006229-7yoilsho	379	16	ones	one	NNS
cord-006229-7yoilsho	379	17	.	.	.
cord-006229-7yoilsho	380	1	Vascular	vascular	JJ
cord-006229-7yoilsho	380	2	endothelial	endothelial	JJ
cord-006229-7yoilsho	380	3	growth	growth	NN
cord-006229-7yoilsho	380	4	factor	factor	NN
cord-006229-7yoilsho	380	5	(	(	-LRB-
cord-006229-7yoilsho	380	6	VEGF	VEGF	NNP
cord-006229-7yoilsho	380	7	)	)	-RRB-
cord-006229-7yoilsho	380	8	is	be	VBZ
cord-006229-7yoilsho	380	9	the	the	DT
cord-006229-7yoilsho	380	10	most	most	RBS
cord-006229-7yoilsho	380	11	studied	study	VBN
cord-006229-7yoilsho	380	12	regulator	regulator	NN
cord-006229-7yoilsho	380	13	of	of	IN
cord-006229-7yoilsho	380	14	this	this	DT
cord-006229-7yoilsho	380	15	process	process	NN
cord-006229-7yoilsho	380	16	.	.	.
cord-006229-7yoilsho	381	1	By	by	IN
cord-006229-7yoilsho	381	2	binding	bind	VBG
cord-006229-7yoilsho	381	3	to	to	IN
cord-006229-7yoilsho	381	4	its	-PRON-	PRP$
cord-006229-7yoilsho	381	5	type	type	NN
cord-006229-7yoilsho	381	6	2	2	CD
cord-006229-7yoilsho	381	7	receptor	receptor	NN
cord-006229-7yoilsho	381	8	(	(	-LRB-
cord-006229-7yoilsho	381	9	VEGFR2	VEGFR2	NNP
cord-006229-7yoilsho	381	10	)	)	-RRB-
cord-006229-7yoilsho	381	11	,	,	,
cord-006229-7yoilsho	381	12	it	-PRON-	PRP
cord-006229-7yoilsho	381	13	has	have	VBZ
cord-006229-7yoilsho	381	14	been	be	VBN
cord-006229-7yoilsho	381	15	shown	show	VBN
cord-006229-7yoilsho	381	16	to	to	TO
cord-006229-7yoilsho	381	17	activate	activate	VB
cord-006229-7yoilsho	381	18	a	a	DT
cord-006229-7yoilsho	381	19	variety	variety	NN
cord-006229-7yoilsho	381	20	of	of	IN
cord-006229-7yoilsho	381	21	different	different	JJ
cord-006229-7yoilsho	381	22	signaling	signaling	NN
cord-006229-7yoilsho	381	23	-	-	HYPH
cord-006229-7yoilsho	381	24	pathways	pathway	NNS
cord-006229-7yoilsho	381	25	leading	lead	VBG
cord-006229-7yoilsho	381	26	to	to	IN
cord-006229-7yoilsho	381	27	enhanced	enhanced	JJ
cord-006229-7yoilsho	381	28	angiogenesis	angiogenesis	NN
cord-006229-7yoilsho	381	29	.	.	.
cord-006229-7yoilsho	382	1	cAMP	camp	NN
cord-006229-7yoilsho	382	2	,	,	,
cord-006229-7yoilsho	382	3	on	on	IN
cord-006229-7yoilsho	382	4	the	the	DT
cord-006229-7yoilsho	382	5	other	other	JJ
cord-006229-7yoilsho	382	6	hand	hand	NN
cord-006229-7yoilsho	382	7	,	,	,
cord-006229-7yoilsho	382	8	is	be	VBZ
cord-006229-7yoilsho	382	9	a	a	DT
cord-006229-7yoilsho	382	10	versatile	versatile	JJ
cord-006229-7yoilsho	382	11	second	second	JJ
cord-006229-7yoilsho	382	12	messenger	messenger	NN
cord-006229-7yoilsho	382	13	which	which	WDT
cord-006229-7yoilsho	382	14	regulates	regulate	VBZ
cord-006229-7yoilsho	382	15	various	various	JJ
cord-006229-7yoilsho	382	16	endothelial	endothelial	JJ
cord-006229-7yoilsho	382	17	functions	function	NNS
cord-006229-7yoilsho	382	18	including	include	VBG
cord-006229-7yoilsho	382	19	barrier	barrier	NN
cord-006229-7yoilsho	382	20	function	function	NN
cord-006229-7yoilsho	382	21	.	.	.
cord-006229-7yoilsho	383	1	It	-PRON-	PRP
cord-006229-7yoilsho	383	2	directly	directly	RB
cord-006229-7yoilsho	383	3	activates	activate	VBZ
cord-006229-7yoilsho	383	4	Protein	Protein	NNP
cord-006229-7yoilsho	383	5	Kinase	Kinase	NNP
cord-006229-7yoilsho	383	6	A	A	NNP
cord-006229-7yoilsho	383	7	(	(	-LRB-
cord-006229-7yoilsho	383	8	PKA	PKA	NNP
cord-006229-7yoilsho	383	9	)	)	-RRB-
cord-006229-7yoilsho	383	10	or	or	CC
cord-006229-7yoilsho	383	11	the	the	DT
cord-006229-7yoilsho	383	12	Exchange	Exchange	NNP
cord-006229-7yoilsho	383	13	protein	protein	NN
cord-006229-7yoilsho	383	14	directly	directly	RB
cord-006229-7yoilsho	383	15	activated	activate	VBN
cord-006229-7yoilsho	383	16	by	by	IN
cord-006229-7yoilsho	383	17	cAMP	camp	NN
cord-006229-7yoilsho	383	18	(	(	-LRB-
cord-006229-7yoilsho	383	19	Epac	Epac	NNP
cord-006229-7yoilsho	383	20	)	)	-RRB-
cord-006229-7yoilsho	383	21	which	which	WDT
cord-006229-7yoilsho	383	22	is	be	VBZ
cord-006229-7yoilsho	383	23	a	a	DT
cord-006229-7yoilsho	383	24	guanine	guanine	NN
cord-006229-7yoilsho	383	25	exchange	exchange	NN
cord-006229-7yoilsho	383	26	factor	factor	NN
cord-006229-7yoilsho	383	27	(	(	-LRB-
cord-006229-7yoilsho	383	28	GEF	GEF	NNP
cord-006229-7yoilsho	383	29	)	)	-RRB-
cord-006229-7yoilsho	383	30	for	for	IN
cord-006229-7yoilsho	383	31	the	the	DT
cord-006229-7yoilsho	383	32	small	small	JJ
cord-006229-7yoilsho	383	33	monomeric	monomeric	JJ
cord-006229-7yoilsho	383	34	GTPase	GTPase	NNP
cord-006229-7yoilsho	383	35	Rap	Rap	NNP
cord-006229-7yoilsho	383	36	.	.	.
cord-006229-7yoilsho	384	1	As	as	IN
cord-006229-7yoilsho	384	2	Human	human	JJ
cord-006229-7yoilsho	384	3	umbilical	umbilical	JJ
cord-006229-7yoilsho	384	4	vein	vein	NN
cord-006229-7yoilsho	384	5	endothelial	endothelial	JJ
cord-006229-7yoilsho	384	6	cells	cell	NNS
cord-006229-7yoilsho	384	7	(	(	-LRB-
cord-006229-7yoilsho	384	8	HUVEC	HUVEC	NNP
cord-006229-7yoilsho	384	9	)	)	-RRB-
cord-006229-7yoilsho	384	10	express	express	VBP
cord-006229-7yoilsho	384	11	both	both	DT
cord-006229-7yoilsho	384	12	cAMP	camp	NN
cord-006229-7yoilsho	384	13	effectors	effector	NNS
cord-006229-7yoilsho	384	14	(	(	-LRB-
cord-006229-7yoilsho	384	15	Epac1	Epac1	NNP
cord-006229-7yoilsho	384	16	and	and	CC
cord-006229-7yoilsho	384	17	PKA	PKA	NNP
cord-006229-7yoilsho	384	18	)	)	-RRB-
cord-006229-7yoilsho	384	19	,	,	,
cord-006229-7yoilsho	384	20	we	-PRON-	PRP
cord-006229-7yoilsho	384	21	investigated	investigate	VBD
cord-006229-7yoilsho	384	22	the	the	DT
cord-006229-7yoilsho	384	23	role	role	NN
cord-006229-7yoilsho	384	24	of	of	IN
cord-006229-7yoilsho	384	25	cAMP	camp	NN
cord-006229-7yoilsho	384	26	-	-	HYPH
cord-006229-7yoilsho	384	27	signaling	signal	VBG
cord-006229-7yoilsho	384	28	using	use	VBG
cord-006229-7yoilsho	384	29	a	a	DT
cord-006229-7yoilsho	384	30	spheroid	spheroid	NN
cord-006229-7yoilsho	384	31	based	base	VBN
cord-006229-7yoilsho	384	32	sprouting	sprout	VBG
cord-006229-7yoilsho	384	33	assay	assay	NN
cord-006229-7yoilsho	384	34	as	as	IN
cord-006229-7yoilsho	384	35	an	an	DT
cord-006229-7yoilsho	384	36	in	in	FW
cord-006229-7yoilsho	384	37	vitro	vitro	FW
cord-006229-7yoilsho	384	38	model	model	NN
cord-006229-7yoilsho	384	39	for	for	IN
cord-006229-7yoilsho	384	40	angiogenesis	angiogenesis	NN
cord-006229-7yoilsho	384	41	.	.	.
cord-006229-7yoilsho	385	1	Interestingly	interestingly	RB
cord-006229-7yoilsho	385	2	,	,	,
cord-006229-7yoilsho	385	3	the	the	DT
cord-006229-7yoilsho	385	4	activation	activation	NN
cord-006229-7yoilsho	385	5	of	of	IN
cord-006229-7yoilsho	385	6	β	β	NN
cord-006229-7yoilsho	385	7	-	-	HYPH
cord-006229-7yoilsho	385	8	adrenergic	adrenergic	JJ
cord-006229-7yoilsho	385	9	receptors	receptor	NNS
cord-006229-7yoilsho	385	10	with	with	IN
cord-006229-7yoilsho	385	11	5	5	CD
cord-006229-7yoilsho	385	12	µM	µm	CD
cord-006229-7yoilsho	385	13	of	of	IN
cord-006229-7yoilsho	385	14	isoproterenol	isoproterenol	NN
cord-006229-7yoilsho	385	15	significantly	significantly	RB
cord-006229-7yoilsho	385	16	increased	increase	VBD
cord-006229-7yoilsho	385	17	the	the	DT
cord-006229-7yoilsho	385	18	cumulative	cumulative	JJ
cord-006229-7yoilsho	385	19	sprout	sprout	NN
cord-006229-7yoilsho	385	20	length	length	NN
cord-006229-7yoilsho	385	21	.	.	.
cord-006229-7yoilsho	386	1	Similarly	similarly	RB
cord-006229-7yoilsho	386	2	,	,	,
cord-006229-7yoilsho	386	3	the	the	DT
cord-006229-7yoilsho	386	4	selective	selective	JJ
cord-006229-7yoilsho	386	5	activation	activation	NN
cord-006229-7yoilsho	386	6	of	of	IN
cord-006229-7yoilsho	386	7	Epac	Epac	NNP
cord-006229-7yoilsho	386	8	with	with	IN
cord-006229-7yoilsho	386	9	30	30	CD
cord-006229-7yoilsho	386	10	µM	µm	CD
cord-006229-7yoilsho	386	11	of	of	IN
cord-006229-7yoilsho	386	12	the	the	DT
cord-006229-7yoilsho	386	13	cAMP	camp	NN
cord-006229-7yoilsho	386	14	analog	analog	NN
cord-006229-7yoilsho	386	15	8-pCPT-2'-O	8-pcpt-2'-o	CD
cord-006229-7yoilsho	386	16	-	-	HYPH
cord-006229-7yoilsho	386	17	cAMP	camp	NN
cord-006229-7yoilsho	386	18	(	(	-LRB-
cord-006229-7yoilsho	386	19	007	007	CD
cord-006229-7yoilsho	386	20	)	)	-RRB-
cord-006229-7yoilsho	386	21	significantly	significantly	RB
cord-006229-7yoilsho	386	22	increased	increase	VBD
cord-006229-7yoilsho	386	23	the	the	DT
cord-006229-7yoilsho	386	24	basal	basal	NN
cord-006229-7yoilsho	386	25	and	and	CC
cord-006229-7yoilsho	386	26	the	the	DT
cord-006229-7yoilsho	386	27	VEGF	VEGF	NNP
cord-006229-7yoilsho	386	28	-	-	HYPH
cord-006229-7yoilsho	386	29	induced	induce	VBN
cord-006229-7yoilsho	386	30	cumulative	cumulative	JJ
cord-006229-7yoilsho	386	31	sprout	sprout	NN
cord-006229-7yoilsho	386	32	length	length	NN
cord-006229-7yoilsho	386	33	.	.	.
cord-006229-7yoilsho	387	1	In	in	IN
cord-006229-7yoilsho	387	2	accordance	accordance	NN
cord-006229-7yoilsho	387	3	,	,	,
cord-006229-7yoilsho	387	4	siRNA	sirna	NN
cord-006229-7yoilsho	387	5	-	-	HYPH
cord-006229-7yoilsho	387	6	mediated	mediate	VBN
cord-006229-7yoilsho	387	7	depletion	depletion	NN
cord-006229-7yoilsho	387	8	of	of	IN
cord-006229-7yoilsho	387	9	Epac1	epac1	NN
cord-006229-7yoilsho	387	10	in	in	IN
cord-006229-7yoilsho	387	11	HUVEC	HUVEC	NNP
cord-006229-7yoilsho	387	12	decreased	decrease	VBD
cord-006229-7yoilsho	387	13	the	the	DT
cord-006229-7yoilsho	387	14	basal	basal	NN
cord-006229-7yoilsho	387	15	and	and	CC
cord-006229-7yoilsho	387	16	VEGF	vegf	NN
cord-006229-7yoilsho	387	17	-	-	HYPH
cord-006229-7yoilsho	387	18	induced	induce	VBN
cord-006229-7yoilsho	387	19	sprouting	sprout	VBG
cord-006229-7yoilsho	387	20	.	.	.
cord-006229-7yoilsho	388	1	Surprisingly	surprisingly	RB
cord-006229-7yoilsho	388	2	,	,	,
cord-006229-7yoilsho	388	3	10	10	CD
cord-006229-7yoilsho	388	4	µM	µm	NN
cord-006229-7yoilsho	388	5	of	of	IN
cord-006229-7yoilsho	388	6	forskolin	forskolin	NN
cord-006229-7yoilsho	388	7	increased	increase	VBN
cord-006229-7yoilsho	388	8	basal	basal	NN
cord-006229-7yoilsho	388	9	and	and	CC
cord-006229-7yoilsho	388	10	VEGF	vegf	NN
cord-006229-7yoilsho	388	11	-	-	HYPH
cord-006229-7yoilsho	388	12	induced	induce	VBN
cord-006229-7yoilsho	388	13	cumulative	cumulative	JJ
cord-006229-7yoilsho	388	14	sprout	sprout	NN
cord-006229-7yoilsho	388	15	length	length	VBD
cord-006229-7yoilsho	388	16	stronger	strong	JJR
cord-006229-7yoilsho	388	17	than	than	IN
cord-006229-7yoilsho	388	18	007	007	CD
cord-006229-7yoilsho	388	19	,	,	,
cord-006229-7yoilsho	388	20	indicating	indicate	VBG
cord-006229-7yoilsho	388	21	an	an	DT
cord-006229-7yoilsho	388	22	additional	additional	JJ
cord-006229-7yoilsho	388	23	role	role	NN
cord-006229-7yoilsho	388	24	of	of	IN
cord-006229-7yoilsho	388	25	PKA	PKA	NNP
cord-006229-7yoilsho	388	26	.	.	.
cord-006229-7yoilsho	389	1	In	in	IN
cord-006229-7yoilsho	389	2	accordance	accordance	NN
cord-006229-7yoilsho	389	3	,	,	,
cord-006229-7yoilsho	389	4	1	1	CD
cord-006229-7yoilsho	389	5	µM	µm	CD
cord-006229-7yoilsho	389	6	of	of	IN
cord-006229-7yoilsho	389	7	myristoylated	myristoylate	VBN
cord-006229-7yoilsho	389	8	PKI	PKI	NNP
cord-006229-7yoilsho	389	9	,	,	,
cord-006229-7yoilsho	389	10	a	a	DT
cord-006229-7yoilsho	389	11	membrane	membrane	NN
cord-006229-7yoilsho	389	12	-	-	HYPH
cord-006229-7yoilsho	389	13	permeable	permeable	JJ
cord-006229-7yoilsho	389	14	specific	specific	JJ
cord-006229-7yoilsho	389	15	PKA	PKA	NNP
cord-006229-7yoilsho	389	16	inhibitor	inhibitor	NN
cord-006229-7yoilsho	389	17	,	,	,
cord-006229-7yoilsho	389	18	significantly	significantly	RB
cord-006229-7yoilsho	389	19	attenuated	attenuate	VBD
cord-006229-7yoilsho	389	20	the	the	DT
cord-006229-7yoilsho	389	21	forskolin	forskolin	NN
cord-006229-7yoilsho	389	22	-	-	HYPH
cord-006229-7yoilsho	389	23	induced	induce	VBN
cord-006229-7yoilsho	389	24	increase	increase	NN
cord-006229-7yoilsho	389	25	in	in	IN
cord-006229-7yoilsho	389	26	sprouting	sprout	VBG
cord-006229-7yoilsho	389	27	.	.	.
cord-006229-7yoilsho	390	1	In	in	IN
cord-006229-7yoilsho	390	2	all	all	DT
cord-006229-7yoilsho	390	3	conditions	condition	NNS
cord-006229-7yoilsho	390	4	tested	test	VBN
cord-006229-7yoilsho	390	5	,	,	,
cord-006229-7yoilsho	390	6	50	50	CD
cord-006229-7yoilsho	390	7	ng	ng	NN
cord-006229-7yoilsho	390	8	/	/	SYM
cord-006229-7yoilsho	390	9	ml	ml	NNS
cord-006229-7yoilsho	390	10	of	of	IN
cord-006229-7yoilsho	390	11	VEGF	VEGF	NNP
cord-006229-7yoilsho	390	12	always	always	RB
cord-006229-7yoilsho	390	13	showed	show	VBD
cord-006229-7yoilsho	390	14	an	an	DT
cord-006229-7yoilsho	390	15	additive	additive	NN
cord-006229-7yoilsho	390	16	effect	effect	NN
cord-006229-7yoilsho	390	17	to	to	IN
cord-006229-7yoilsho	390	18	the	the	DT
cord-006229-7yoilsho	390	19	same	same	JJ
cord-006229-7yoilsho	390	20	extent	extent	NN
cord-006229-7yoilsho	390	21	on	on	IN
cord-006229-7yoilsho	390	22	cumulative	cumulative	JJ
cord-006229-7yoilsho	390	23	sprout	sprout	NN
cord-006229-7yoilsho	390	24	length	length	NN
cord-006229-7yoilsho	390	25	.	.	.
cord-006229-7yoilsho	391	1	Therefore	therefore	RB
cord-006229-7yoilsho	391	2	,	,	,
cord-006229-7yoilsho	391	3	our	-PRON-	PRP$
cord-006229-7yoilsho	391	4	data	datum	NNS
cord-006229-7yoilsho	391	5	indicate	indicate	VBP
cord-006229-7yoilsho	391	6	that	that	IN
cord-006229-7yoilsho	391	7	the	the	DT
cord-006229-7yoilsho	391	8	VEGF	VEGF	NNP
cord-006229-7yoilsho	391	9	-	-	HYPH
cord-006229-7yoilsho	391	10	pathway	pathway	NN
cord-006229-7yoilsho	391	11	is	be	VBZ
cord-006229-7yoilsho	391	12	acting	act	VBG
cord-006229-7yoilsho	391	13	independently	independently	RB
cord-006229-7yoilsho	391	14	of	of	IN
cord-006229-7yoilsho	391	15	the	the	DT
cord-006229-7yoilsho	391	16	cAMP	camp	NN
cord-006229-7yoilsho	391	17	-	-	HYPH
cord-006229-7yoilsho	391	18	pathway	pathway	NN
cord-006229-7yoilsho	391	19	in	in	IN
cord-006229-7yoilsho	391	20	the	the	DT
cord-006229-7yoilsho	391	21	regulation	regulation	NN
cord-006229-7yoilsho	391	22	of	of	IN
cord-006229-7yoilsho	391	23	the	the	DT
cord-006229-7yoilsho	391	24	sprouting	sprout	VBG
cord-006229-7yoilsho	391	25	angiogenesis	angiogenesis	NN
cord-006229-7yoilsho	391	26	.	.	.
cord-006229-7yoilsho	392	1	The	the	DT
cord-006229-7yoilsho	392	2	β	β	NN
cord-006229-7yoilsho	392	3	-	-	HYPH
cord-006229-7yoilsho	392	4	adrenergic	adrenergic	NN
cord-006229-7yoilsho	392	5	receptor	receptor	NN
cord-006229-7yoilsho	392	6	-	-	HYPH
cord-006229-7yoilsho	392	7	mediated	mediate	VBN
cord-006229-7yoilsho	392	8	activation	activation	NN
cord-006229-7yoilsho	392	9	of	of	IN
cord-006229-7yoilsho	392	10	cAMP	camp	NN
cord-006229-7yoilsho	392	11	signaling	signal	VBG
cord-006229-7yoilsho	392	12	in	in	IN
cord-006229-7yoilsho	392	13	HUVEC	HUVEC	NNP
cord-006229-7yoilsho	392	14	induces	induce	VBZ
cord-006229-7yoilsho	392	15	angiogenic	angiogenic	NN
cord-006229-7yoilsho	392	16	sprouting	sprout	VBG
cord-006229-7yoilsho	392	17	by	by	IN
cord-006229-7yoilsho	392	18	activation	activation	NN
cord-006229-7yoilsho	392	19	of	of	IN
cord-006229-7yoilsho	392	20	Epac1	Epac1	NNP
cord-006229-7yoilsho	392	21	and	and	CC
cord-006229-7yoilsho	392	22	PKA	PKA	NNP
cord-006229-7yoilsho	392	23	.	.	.
cord-006229-7yoilsho	393	1	Introduction	introduction	NN
cord-006229-7yoilsho	393	2	:	:	:
cord-006229-7yoilsho	394	1	Hypertension	hypertension	NN
cord-006229-7yoilsho	394	2	is	be	VBZ
cord-006229-7yoilsho	394	3	one	one	CD
cord-006229-7yoilsho	394	4	major	major	JJ
cord-006229-7yoilsho	394	5	risk	risk	NN
cord-006229-7yoilsho	394	6	factor	factor	NN
cord-006229-7yoilsho	394	7	for	for	IN
cord-006229-7yoilsho	394	8	the	the	DT
cord-006229-7yoilsho	394	9	development	development	NN
cord-006229-7yoilsho	394	10	of	of	IN
cord-006229-7yoilsho	394	11	chronic	chronic	JJ
cord-006229-7yoilsho	394	12	heart	heart	NN
cord-006229-7yoilsho	394	13	and	and	CC
cord-006229-7yoilsho	394	14	kidney	kidney	NN
cord-006229-7yoilsho	394	15	disease	disease	NN
cord-006229-7yoilsho	394	16	.	.	.
cord-006229-7yoilsho	395	1	Mineralocorticoid	Mineralocorticoid	NNP
cord-006229-7yoilsho	395	2	receptor	receptor	NN
cord-006229-7yoilsho	395	3	(	(	-LRB-
cord-006229-7yoilsho	395	4	MR	MR	NNP
cord-006229-7yoilsho	395	5	)	)	-RRB-
cord-006229-7yoilsho	395	6	antagonists	antagonist	NNS
cord-006229-7yoilsho	395	7	are	be	VBP
cord-006229-7yoilsho	395	8	a	a	DT
cord-006229-7yoilsho	395	9	cornerstone	cornerstone	NN
cord-006229-7yoilsho	395	10	in	in	IN
cord-006229-7yoilsho	395	11	the	the	DT
cord-006229-7yoilsho	395	12	therapy	therapy	NN
cord-006229-7yoilsho	395	13	of	of	IN
cord-006229-7yoilsho	395	14	heart	heart	NN
cord-006229-7yoilsho	395	15	failure	failure	NN
cord-006229-7yoilsho	395	16	and	and	CC
cord-006229-7yoilsho	395	17	there	there	EX
cord-006229-7yoilsho	395	18	is	be	VBZ
cord-006229-7yoilsho	395	19	first	first	JJ
cord-006229-7yoilsho	395	20	evidence	evidence	NN
cord-006229-7yoilsho	395	21	for	for	IN
cord-006229-7yoilsho	395	22	a	a	DT
cord-006229-7yoilsho	395	23	beneficial	beneficial	JJ
cord-006229-7yoilsho	395	24	effect	effect	NN
cord-006229-7yoilsho	395	25	on	on	IN
cord-006229-7yoilsho	395	26	the	the	DT
cord-006229-7yoilsho	395	27	kidney	kidney	NN
cord-006229-7yoilsho	395	28	as	as	RB
cord-006229-7yoilsho	395	29	well	well	RB
cord-006229-7yoilsho	395	30	.	.	.
cord-006229-7yoilsho	396	1	Inflammation	inflammation	NN
cord-006229-7yoilsho	396	2	plays	play	VBZ
cord-006229-7yoilsho	396	3	an	an	DT
cord-006229-7yoilsho	396	4	important	important	JJ
cord-006229-7yoilsho	396	5	role	role	NN
cord-006229-7yoilsho	396	6	in	in	IN
cord-006229-7yoilsho	396	7	hypertensive	hypertensive	JJ
cord-006229-7yoilsho	396	8	organ	organ	NN
cord-006229-7yoilsho	396	9	injury	injury	NN
cord-006229-7yoilsho	396	10	.	.	.
cord-006229-7yoilsho	397	1	Thus	thus	RB
cord-006229-7yoilsho	397	2	,	,	,
cord-006229-7yoilsho	397	3	this	this	DT
cord-006229-7yoilsho	397	4	study	study	NN
cord-006229-7yoilsho	397	5	was	be	VBD
cord-006229-7yoilsho	397	6	designed	design	VBN
cord-006229-7yoilsho	397	7	to	to	TO
cord-006229-7yoilsho	397	8	evaluate	evaluate	VB
cord-006229-7yoilsho	397	9	and	and	CC
cord-006229-7yoilsho	397	10	directly	directly	RB
cord-006229-7yoilsho	397	11	compare	compare	VB
cord-006229-7yoilsho	397	12	the	the	DT
cord-006229-7yoilsho	397	13	effect	effect	NN
cord-006229-7yoilsho	397	14	of	of	IN
cord-006229-7yoilsho	397	15	MR	MR	NNP
cord-006229-7yoilsho	397	16	deletion	deletion	NN
cord-006229-7yoilsho	397	17	in	in	IN
cord-006229-7yoilsho	397	18	endothelial	endothelial	JJ
cord-006229-7yoilsho	397	19	cells	cell	NNS
cord-006229-7yoilsho	397	20	on	on	IN
cord-006229-7yoilsho	397	21	blood	blood	NN
cord-006229-7yoilsho	397	22	pressure	pressure	NN
cord-006229-7yoilsho	397	23	and	and	CC
cord-006229-7yoilsho	397	24	cardiac	cardiac	JJ
cord-006229-7yoilsho	397	25	vs.	vs.	FW
cord-006229-7yoilsho	397	26	renal	renal	JJ
cord-006229-7yoilsho	397	27	injury	injury	NN
cord-006229-7yoilsho	397	28	in	in	IN
cord-006229-7yoilsho	397	29	a	a	DT
cord-006229-7yoilsho	397	30	mouse	mouse	NN
cord-006229-7yoilsho	397	31	model	model	NN
cord-006229-7yoilsho	397	32	of	of	IN
cord-006229-7yoilsho	397	33	deoxycorticosterone	deoxycorticosterone	NNP
cord-006229-7yoilsho	397	34	acetate	acetate	NN
cord-006229-7yoilsho	397	35	-	-	HYPH
cord-006229-7yoilsho	397	36	induced	induce	VBN
cord-006229-7yoilsho	397	37	hypertension	hypertension	NN
cord-006229-7yoilsho	397	38	.	.	.
cord-006229-7yoilsho	398	1	Methods	method	NNS
cord-006229-7yoilsho	398	2	and	and	CC
cord-006229-7yoilsho	398	3	results	result	NNS
cord-006229-7yoilsho	398	4	:	:	:
cord-006229-7yoilsho	398	5	Mice	mouse	NNS
cord-006229-7yoilsho	398	6	lacking	lack	VBG
cord-006229-7yoilsho	398	7	the	the	DT
cord-006229-7yoilsho	398	8	mineralocorticoid	mineralocorticoid	NN
cord-006229-7yoilsho	398	9	receptor	receptor	NN
cord-006229-7yoilsho	398	10	in	in	IN
cord-006229-7yoilsho	398	11	endothelial	endothelial	JJ
cord-006229-7yoilsho	398	12	cells	cell	NNS
cord-006229-7yoilsho	398	13	(	(	-LRB-
cord-006229-7yoilsho	398	14	MR	MR	NNP
cord-006229-7yoilsho	398	15	Cdh5Cre	Cdh5Cre	NNP
cord-006229-7yoilsho	398	16	)	)	-RRB-
cord-006229-7yoilsho	398	17	were	be	VBD
cord-006229-7yoilsho	398	18	created	create	VBN
cord-006229-7yoilsho	398	19	using	use	VBG
cord-006229-7yoilsho	398	20	the	the	DT
cord-006229-7yoilsho	398	21	Cre	Cre	NNP
cord-006229-7yoilsho	398	22	/	/	SYM
cord-006229-7yoilsho	398	23	loxP	loxP	NNP
cord-006229-7yoilsho	398	24	system	system	NN
cord-006229-7yoilsho	398	25	.	.	.
cord-006229-7yoilsho	399	1	MR	MR	NNP
cord-006229-7yoilsho	399	2	Cdh5Cre	Cdh5Cre	NNP
cord-006229-7yoilsho	399	3	and	and	CC
cord-006229-7yoilsho	399	4	Cre	cre	JJ
cord-006229-7yoilsho	399	5	-	-	HYPH
cord-006229-7yoilsho	399	6	negative	negative	JJ
cord-006229-7yoilsho	399	7	littermates	littermate	NNS
cord-006229-7yoilsho	400	1	(	(	-LRB-
cord-006229-7yoilsho	400	2	MR	MR	NNP
cord-006229-7yoilsho	400	3	wildtype	wildtype	NN
cord-006229-7yoilsho	400	4	)	)	-RRB-
cord-006229-7yoilsho	400	5	underwent	undergo	VBD
cord-006229-7yoilsho	400	6	unilateral	unilateral	JJ
cord-006229-7yoilsho	400	7	nephrectomy	nephrectomy	NN
cord-006229-7yoilsho	400	8	and	and	CC
cord-006229-7yoilsho	400	9	received	receive	VBD
cord-006229-7yoilsho	400	10	1	1	CD
cord-006229-7yoilsho	400	11	%	%	NN
cord-006229-7yoilsho	400	12	NaCl	nacl	NN
cord-006229-7yoilsho	400	13	with	with	IN
cord-006229-7yoilsho	400	14	drinking	drinking	NN
cord-006229-7yoilsho	400	15	water	water	NN
cord-006229-7yoilsho	400	16	for	for	IN
cord-006229-7yoilsho	400	17	6	6	CD
cord-006229-7yoilsho	400	18	weeks	week	NNS
cord-006229-7yoilsho	400	19	.	.	.
cord-006229-7yoilsho	401	1	The	the	DT
cord-006229-7yoilsho	401	2	mineralocorticoid	mineralocorticoid	NN
cord-006229-7yoilsho	401	3	deoxycorticosterone	deoxycorticosterone	NN
cord-006229-7yoilsho	401	4	acetate	acetate	NN
cord-006229-7yoilsho	401	5	(	(	-LRB-
cord-006229-7yoilsho	401	6	DOCA	DOCA	NNP
cord-006229-7yoilsho	401	7	,	,	,
cord-006229-7yoilsho	401	8	2.5	2.5	CD
cord-006229-7yoilsho	401	9	mg	mg	NNP
cord-006229-7yoilsho	401	10	/	/	SYM
cord-006229-7yoilsho	401	11	d	d	NN
cord-006229-7yoilsho	401	12	)	)	-RRB-
cord-006229-7yoilsho	401	13	was	be	VBD
cord-006229-7yoilsho	401	14	delivered	deliver	VBN
cord-006229-7yoilsho	401	15	by	by	IN
cord-006229-7yoilsho	401	16	subcutaneous	subcutaneous	JJ
cord-006229-7yoilsho	401	17	pellets	pellet	NNS
cord-006229-7yoilsho	401	18	.	.	.
cord-006229-7yoilsho	402	1	Untreated	untreated	JJ
cord-006229-7yoilsho	402	2	mice	mouse	NNS
cord-006229-7yoilsho	402	3	served	serve	VBD
cord-006229-7yoilsho	402	4	as	as	IN
cord-006229-7yoilsho	402	5	controls	control	NNS
cord-006229-7yoilsho	402	6	(	(	-LRB-
cord-006229-7yoilsho	402	7	CTRL	CTRL	NNP
cord-006229-7yoilsho	402	8	)	)	-RRB-
cord-006229-7yoilsho	402	9	.	.	.
cord-006229-7yoilsho	403	1	Ambulatory	ambulatory	JJ
cord-006229-7yoilsho	403	2	blood	blood	NN
cord-006229-7yoilsho	403	3	pressure	pressure	NN
cord-006229-7yoilsho	403	4	was	be	VBD
cord-006229-7yoilsho	403	5	determined	determine	VBN
cord-006229-7yoilsho	403	6	by	by	IN
cord-006229-7yoilsho	403	7	implantable	implantable	JJ
cord-006229-7yoilsho	403	8	telemetry	telemetry	NN
cord-006229-7yoilsho	403	9	in	in	IN
cord-006229-7yoilsho	403	10	awake	awake	JJ
cord-006229-7yoilsho	403	11	mice	mouse	NNS
cord-006229-7yoilsho	403	12	.	.	.
cord-006229-7yoilsho	404	1	DOCA	DOCA	NNP
cord-006229-7yoilsho	404	2	/	/	SYM
cord-006229-7yoilsho	404	3	salt	salt	NN
cord-006229-7yoilsho	404	4	treatment	treatment	NN
cord-006229-7yoilsho	404	5	increased	increase	VBD
cord-006229-7yoilsho	404	6	mean	mean	JJ
cord-006229-7yoilsho	404	7	blood	blood	NN
cord-006229-7yoilsho	404	8	pressure	pressure	NN
cord-006229-7yoilsho	404	9	in	in	IN
cord-006229-7yoilsho	404	10	MR	MR	NNP
cord-006229-7yoilsho	404	11	wildtype	wildtype	NN
cord-006229-7yoilsho	404	12	(	(	-LRB-
cord-006229-7yoilsho	404	13	141.7	141.7	CD
cord-006229-7yoilsho	404	14	±	±	NNP
cord-006229-7yoilsho	404	15	8.0	8.0	CD
cord-006229-7yoilsho	404	16	vs.	vs.	NN
cord-006229-7yoilsho	404	17	CTRL	ctrl	NN
cord-006229-7yoilsho	404	18	97.8	97.8	CD
cord-006229-7yoilsho	404	19	±	±	CD
cord-006229-7yoilsho	404	20	3.2	3.2	CD
cord-006229-7yoilsho	404	21	mmHg	mmHg	NNS
cord-006229-7yoilsho	404	22	,	,	,
cord-006229-7yoilsho	404	23	P<0.001	P<0.001	NNP
cord-006229-7yoilsho	404	24	)	)	-RRB-
cord-006229-7yoilsho	404	25	and	and	CC
cord-006229-7yoilsho	404	26	MR	MR	NNP
cord-006229-7yoilsho	404	27	Cdh5Cre	Cdh5Cre	NNP
cord-006229-7yoilsho	404	28	(	(	-LRB-
cord-006229-7yoilsho	404	29	150.0	150.0	CD
cord-006229-7yoilsho	404	30	±	±	NNP
cord-006229-7yoilsho	404	31	3.0	3.0	CD
cord-006229-7yoilsho	404	32	vs.	vs.	IN
cord-006229-7yoilsho	404	33	CTRL	CTRL	NNP
cord-006229-7yoilsho	404	34	104.1	104.1	CD
cord-006229-7yoilsho	404	35	±	±	NN
cord-006229-7yoilsho	404	36	4.7	4.7	CD
cord-006229-7yoilsho	404	37	mmHg	mmHg	NNS
cord-006229-7yoilsho	404	38	,	,	,
cord-006229-7yoilsho	404	39	P<0.001	P<0.001	NNP
cord-006229-7yoilsho	404	40	)	)	-RRB-
cord-006229-7yoilsho	404	41	without	without	IN
cord-006229-7yoilsho	404	42	differences	difference	NNS
cord-006229-7yoilsho	404	43	between	between	IN
cord-006229-7yoilsho	404	44	genotypes	genotype	NNS
cord-006229-7yoilsho	404	45	.	.	.
cord-006229-7yoilsho	405	1	Cardiac	cardiac	JJ
cord-006229-7yoilsho	405	2	hypertrophy	hypertrophy	NN
cord-006229-7yoilsho	405	3	after	after	IN
cord-006229-7yoilsho	405	4	DOCA	DOCA	NNP
cord-006229-7yoilsho	405	5	/	/	SYM
cord-006229-7yoilsho	405	6	salt	salt	NN
cord-006229-7yoilsho	405	7	treatment	treatment	NN
cord-006229-7yoilsho	405	8	was	be	VBD
cord-006229-7yoilsho	405	9	ameliorated	ameliorate	VBN
cord-006229-7yoilsho	405	10	in	in	IN
cord-006229-7yoilsho	405	11	MR	MR	NNP
cord-006229-7yoilsho	405	12	Cdh5Cre	cdh5cre	JJ
cord-006229-7yoilsho	405	13	mice	mouse	NNS
cord-006229-7yoilsho	405	14	(	(	-LRB-
cord-006229-7yoilsho	405	15	ventricle	ventricle	NN
cord-006229-7yoilsho	405	16	weight	weight	NN
cord-006229-7yoilsho	406	1	162.4	162.4	CD
cord-006229-7yoilsho	406	2	±	±	CD
cord-006229-7yoilsho	406	3	4.2	4.2	CD
cord-006229-7yoilsho	406	4	mg	mg	NNP
cord-006229-7yoilsho	406	5	vs.	vs.	IN
cord-006229-7yoilsho	406	6	MR	MR	NNP
cord-006229-7yoilsho	406	7	wildtype	wildtype	NN
cord-006229-7yoilsho	406	8	189.0	189.0	CD
cord-006229-7yoilsho	406	9	±	±	CD
cord-006229-7yoilsho	406	10	10.9	10.9	CD
cord-006229-7yoilsho	406	11	mg	mg	NNS
cord-006229-7yoilsho	406	12	,	,	,
cord-006229-7yoilsho	406	13	P<0.05	P<0.05	NNS
cord-006229-7yoilsho	406	14	)	)	-RRB-
cord-006229-7yoilsho	406	15	.	.	.
cord-006229-7yoilsho	407	1	DOCA	DOCA	NNP
cord-006229-7yoilsho	407	2	/	/	SYM
cord-006229-7yoilsho	407	3	salt	salt	NN
cord-006229-7yoilsho	407	4	significantly	significantly	RB
cord-006229-7yoilsho	407	5	increased	increase	VBD
cord-006229-7yoilsho	407	6	cardiac	cardiac	JJ
cord-006229-7yoilsho	407	7	fibrosis	fibrosis	NN
cord-006229-7yoilsho	407	8	and	and	CC
cord-006229-7yoilsho	407	9	the	the	DT
cord-006229-7yoilsho	407	10	expression	expression	NN
cord-006229-7yoilsho	407	11	of	of	IN
cord-006229-7yoilsho	407	12	fibrotic	fibrotic	JJ
cord-006229-7yoilsho	407	13	marker	marker	NN
cord-006229-7yoilsho	407	14	genes	gene	NNS
cord-006229-7yoilsho	407	15	in	in	IN
cord-006229-7yoilsho	407	16	MR	MR	NNP
cord-006229-7yoilsho	407	17	wildtype	wildtype	NN
cord-006229-7yoilsho	407	18	but	but	CC
cord-006229-7yoilsho	407	19	not	not	RB
cord-006229-7yoilsho	407	20	in	in	IN
cord-006229-7yoilsho	407	21	MR	MR	NNP
cord-006229-7yoilsho	407	22	Cdh5Cre	cdh5cre	JJ
cord-006229-7yoilsho	407	23	mice	mouse	NNS
cord-006229-7yoilsho	407	24	.	.	.
cord-006229-7yoilsho	408	1	This	this	DT
cord-006229-7yoilsho	408	2	was	be	VBD
cord-006229-7yoilsho	408	3	accompanied	accompany	VBN
cord-006229-7yoilsho	408	4	by	by	IN
cord-006229-7yoilsho	408	5	an	an	DT
cord-006229-7yoilsho	408	6	increased	increase	VBN
cord-006229-7yoilsho	408	7	expression	expression	NN
cord-006229-7yoilsho	408	8	of	of	IN
cord-006229-7yoilsho	408	9	the	the	DT
cord-006229-7yoilsho	408	10	vascular	vascular	JJ
cord-006229-7yoilsho	408	11	cellular	cellular	JJ
cord-006229-7yoilsho	408	12	adhesion	adhesion	NN
cord-006229-7yoilsho	408	13	molecule	molecule	NN
cord-006229-7yoilsho	408	14	(	(	-LRB-
cord-006229-7yoilsho	408	15	Vcam1	Vcam1	NNP
cord-006229-7yoilsho	408	16	)	)	-RRB-
cord-006229-7yoilsho	408	17	in	in	IN
cord-006229-7yoilsho	408	18	MR	MR	NNP
cord-006229-7yoilsho	408	19	wildtype	wildtype	JJ
cord-006229-7yoilsho	408	20	cardiac	cardiac	JJ
cord-006229-7yoilsho	408	21	endothelial	endothelial	JJ
cord-006229-7yoilsho	408	22	cells	cell	NNS
cord-006229-7yoilsho	408	23	.	.	.
cord-006229-7yoilsho	409	1	Renal	renal	JJ
cord-006229-7yoilsho	409	2	function	function	NN
cord-006229-7yoilsho	409	3	was	be	VBD
cord-006229-7yoilsho	409	4	not	not	RB
cord-006229-7yoilsho	409	5	altered	alter	VBN
cord-006229-7yoilsho	409	6	by	by	IN
cord-006229-7yoilsho	409	7	MR	MR	NNP
cord-006229-7yoilsho	409	8	deletion	deletion	NN
cord-006229-7yoilsho	409	9	in	in	IN
cord-006229-7yoilsho	409	10	endothelial	endothelial	JJ
cord-006229-7yoilsho	409	11	cells	cell	NNS
cord-006229-7yoilsho	409	12	at	at	IN
cord-006229-7yoilsho	409	13	baseline	baseline	NN
cord-006229-7yoilsho	409	14	.	.	.
cord-006229-7yoilsho	410	1	DOCA	DOCA	NNP
cord-006229-7yoilsho	410	2	/	/	SYM
cord-006229-7yoilsho	410	3	salt	salt	NN
cord-006229-7yoilsho	410	4	treatment	treatment	NN
cord-006229-7yoilsho	410	5	lead	lead	NN
cord-006229-7yoilsho	410	6	to	to	IN
cord-006229-7yoilsho	410	7	marked	mark	VBN
cord-006229-7yoilsho	410	8	interstitial	interstitial	JJ
cord-006229-7yoilsho	410	9	fibrosis	fibrosis	NN
cord-006229-7yoilsho	410	10	in	in	IN
cord-006229-7yoilsho	410	11	the	the	DT
cord-006229-7yoilsho	410	12	kidneys	kidney	NNS
cord-006229-7yoilsho	410	13	of	of	IN
cord-006229-7yoilsho	410	14	MR	MR	NNP
cord-006229-7yoilsho	410	15	wildtype	wildtype	NNP
cord-006229-7yoilsho	410	16	(	(	-LRB-
cord-006229-7yoilsho	410	17	sirius	sirius	NNP
cord-006229-7yoilsho	410	18	red	red	NNP
cord-006229-7yoilsho	410	19	fibrosis	fibrosis	NNP
cord-006229-7yoilsho	410	20	score	score	NN
cord-006229-7yoilsho	410	21	:	:	:
cord-006229-7yoilsho	410	22	2.4	2.4	CD
cord-006229-7yoilsho	410	23	±	±	CD
cord-006229-7yoilsho	410	24	0.2	0.2	CD
cord-006229-7yoilsho	410	25	vs.	vs.	CC
cord-006229-7yoilsho	410	26	CTRL	ctrl	NN
cord-006229-7yoilsho	410	27	0.1	0.1	CD
cord-006229-7yoilsho	410	28	±	±	CD
cord-006229-7yoilsho	410	29	0.1	0.1	CD
cord-006229-7yoilsho	410	30	,	,	,
cord-006229-7yoilsho	410	31	P<0.001	P<0.001	NNP
cord-006229-7yoilsho	410	32	)	)	-RRB-
cord-006229-7yoilsho	410	33	and	and	CC
cord-006229-7yoilsho	410	34	MR	MR	NNP
cord-006229-7yoilsho	410	35	Cdh5Cre	Cdh5Cre	NNP
cord-006229-7yoilsho	410	36	(	(	-LRB-
cord-006229-7yoilsho	410	37	2.3	2.3	CD
cord-006229-7yoilsho	410	38	±	±	NNP
cord-006229-7yoilsho	410	39	0.2	0.2	CD
cord-006229-7yoilsho	410	40	vs.	vs.	CC
cord-006229-7yoilsho	410	41	CTRL	ctrl	NN
cord-006229-7yoilsho	410	42	0.1	0.1	CD
cord-006229-7yoilsho	410	43	±	±	CD
cord-006229-7yoilsho	410	44	0.1	0.1	CD
cord-006229-7yoilsho	410	45	,	,	,
cord-006229-7yoilsho	410	46	P<0.001	P<0.001	NNS
cord-006229-7yoilsho	410	47	)	)	-RRB-
cord-006229-7yoilsho	410	48	mice	mouse	NNS
cord-006229-7yoilsho	410	49	.	.	.
cord-006229-7yoilsho	411	1	mRNA	mRNA	NNP
cord-006229-7yoilsho	411	2	expression	expression	NN
cord-006229-7yoilsho	411	3	of	of	IN
cord-006229-7yoilsho	411	4	the	the	DT
cord-006229-7yoilsho	411	5	fibrosis	fibrosis	NN
cord-006229-7yoilsho	411	6	marker	marker	NN
cord-006229-7yoilsho	411	7	gene	gene	NN
cord-006229-7yoilsho	411	8	Col3a1	Col3a1	NNPS
cord-006229-7yoilsho	411	9	(	(	-LRB-
cord-006229-7yoilsho	411	10	MR	MR	NNP
cord-006229-7yoilsho	411	11	wildtype	wildtype	NN
cord-006229-7yoilsho	411	12	4.3	4.3	CD
cord-006229-7yoilsho	411	13	±	±	CD
cord-006229-7yoilsho	411	14	0.9-fold	0.9-fold	CD
cord-006229-7yoilsho	411	15	;	;	:
cord-006229-7yoilsho	411	16	MR	MR	NNP
cord-006229-7yoilsho	411	17	Cdh5Cre	Cdh5Cre	NNP
cord-006229-7yoilsho	411	18	3.9	3.9	CD
cord-006229-7yoilsho	411	19	±	±	CD
cord-006229-7yoilsho	411	20	1.1-fold	1.1-fold	CD
cord-006229-7yoilsho	411	21	vs.	vs.	IN
cord-006229-7yoilsho	411	22	CTRL	ctrl	NN
cord-006229-7yoilsho	411	23	)	)	-RRB-
cord-006229-7yoilsho	411	24	was	be	VBD
cord-006229-7yoilsho	411	25	similarly	similarly	RB
cord-006229-7yoilsho	411	26	increased	increase	VBN
cord-006229-7yoilsho	411	27	.	.	.
cord-006229-7yoilsho	412	1	Periodic	periodic	JJ
cord-006229-7yoilsho	412	2	acid	acid	NN
cord-006229-7yoilsho	412	3	-	-	HYPH
cord-006229-7yoilsho	412	4	Schiff	Schiff	NNP
cord-006229-7yoilsho	412	5	staining	staining	NN
cord-006229-7yoilsho	412	6	revealed	reveal	VBD
cord-006229-7yoilsho	412	7	glomerular	glomerular	JJ
cord-006229-7yoilsho	412	8	injury	injury	NN
cord-006229-7yoilsho	412	9	in	in	IN
cord-006229-7yoilsho	412	10	both	both	DT
cord-006229-7yoilsho	412	11	genotypes	genotype	NNS
cord-006229-7yoilsho	412	12	.	.	.
cord-006229-7yoilsho	413	1	This	this	DT
cord-006229-7yoilsho	413	2	was	be	VBD
cord-006229-7yoilsho	413	3	associated	associate	VBN
cord-006229-7yoilsho	413	4	with	with	IN
cord-006229-7yoilsho	413	5	a	a	DT
cord-006229-7yoilsho	413	6	marked	marked	JJ
cord-006229-7yoilsho	413	7	rise	rise	NN
cord-006229-7yoilsho	413	8	in	in	IN
cord-006229-7yoilsho	413	9	urinary	urinary	JJ
cord-006229-7yoilsho	413	10	albumin	albumin	NN
cord-006229-7yoilsho	413	11	/	/	SYM
cord-006229-7yoilsho	413	12	creatinine	creatinine	NN
cord-006229-7yoilsho	413	13	ratio	ratio	NN
cord-006229-7yoilsho	413	14	(	(	-LRB-
cord-006229-7yoilsho	414	1	MR	MR	NNP
cord-006229-7yoilsho	414	2	wildtype	wildtype	NN
cord-006229-7yoilsho	414	3	20.4	20.4	CD
cord-006229-7yoilsho	414	4	±	±	NNP
cord-006229-7yoilsho	414	5	5.7fold	5.7fold	CD
cord-006229-7yoilsho	414	6	;	;	:
cord-006229-7yoilsho	414	7	MR	MR	NNP
cord-006229-7yoilsho	414	8	Cdh5Cre	Cdh5Cre	NNP
cord-006229-7yoilsho	414	9	34.3	34.3	CD
cord-006229-7yoilsho	414	10	±	±	NNP
cord-006229-7yoilsho	414	11	12.5-fold	12.5-fold	CD
cord-006229-7yoilsho	414	12	vs.	vs.	IN
cord-006229-7yoilsho	414	13	CTRL	ctrl	NN
cord-006229-7yoilsho	414	14	)	)	-RRB-
cord-006229-7yoilsho	414	15	.	.	.
cord-006229-7yoilsho	415	1	In	in	IN
cord-006229-7yoilsho	415	2	the	the	DT
cord-006229-7yoilsho	415	3	kidney	kidney	NN
cord-006229-7yoilsho	415	4	Vcam1	Vcam1	NNP
cord-006229-7yoilsho	415	5	mRNA	mRNA	NNP
cord-006229-7yoilsho	415	6	expression	expression	NN
cord-006229-7yoilsho	415	7	and	and	CC
cord-006229-7yoilsho	415	8	the	the	DT
cord-006229-7yoilsho	415	9	number	number	NN
cord-006229-7yoilsho	415	10	of	of	IN
cord-006229-7yoilsho	415	11	macrophages	macrophage	NNS
cord-006229-7yoilsho	415	12	was	be	VBD
cord-006229-7yoilsho	415	13	increased	increase	VBN
cord-006229-7yoilsho	415	14	by	by	IN
cord-006229-7yoilsho	415	15	DOCA	DOCA	NNP
cord-006229-7yoilsho	415	16	/	/	SYM
cord-006229-7yoilsho	415	17	salt	salt	NN
cord-006229-7yoilsho	415	18	treatment	treatment	NN
cord-006229-7yoilsho	415	19	independently	independently	RB
cord-006229-7yoilsho	415	20	from	from	IN
cord-006229-7yoilsho	415	21	endothelial	endothelial	JJ
cord-006229-7yoilsho	415	22	MR	MR	NNP
cord-006229-7yoilsho	415	23	deletion	deletion	NN
cord-006229-7yoilsho	415	24	.	.	.
cord-006229-7yoilsho	416	1	Conclusion	conclusion	NN
cord-006229-7yoilsho	416	2	:	:	:
cord-006229-7yoilsho	417	1	In	in	IN
cord-006229-7yoilsho	417	2	conclusion	conclusion	NN
cord-006229-7yoilsho	417	3	,	,	,
cord-006229-7yoilsho	417	4	MR	MR	NNP
cord-006229-7yoilsho	417	5	deletion	deletion	NN
cord-006229-7yoilsho	417	6	from	from	IN
cord-006229-7yoilsho	417	7	endothelial	endothelial	JJ
cord-006229-7yoilsho	417	8	cells	cell	NNS
cord-006229-7yoilsho	417	9	ameliorated	ameliorate	VBD
cord-006229-7yoilsho	417	10	DOCA	DOCA	NNP
cord-006229-7yoilsho	417	11	/	/	SYM
cord-006229-7yoilsho	417	12	saltinduced	saltinduce	VBN
cord-006229-7yoilsho	417	13	cardiac	cardiac	NN
cord-006229-7yoilsho	417	14	but	but	CC
cord-006229-7yoilsho	417	15	not	not	RB
cord-006229-7yoilsho	417	16	renal	renal	JJ
cord-006229-7yoilsho	417	17	inflammation	inflammation	NN
cord-006229-7yoilsho	417	18	and	and	CC
cord-006229-7yoilsho	417	19	remodeling	remodeling	NN
cord-006229-7yoilsho	417	20	independently	independently	RB
cord-006229-7yoilsho	417	21	from	from	IN
cord-006229-7yoilsho	417	22	blood	blood	NN
cord-006229-7yoilsho	417	23	pressure	pressure	NN
cord-006229-7yoilsho	417	24	.	.	.
cord-006229-7yoilsho	418	1	These	these	DT
cord-006229-7yoilsho	418	2	findings	finding	NNS
cord-006229-7yoilsho	418	3	suggest	suggest	VBP
cord-006229-7yoilsho	418	4	different	different	JJ
cord-006229-7yoilsho	418	5	mechanisms	mechanism	NNS
cord-006229-7yoilsho	418	6	for	for	IN
cord-006229-7yoilsho	418	7	the	the	DT
cord-006229-7yoilsho	418	8	beneficial	beneficial	JJ
cord-006229-7yoilsho	418	9	effect	effect	NN
cord-006229-7yoilsho	418	10	of	of	IN
cord-006229-7yoilsho	418	11	MR	MR	NNP
cord-006229-7yoilsho	418	12	antagonists	antagonist	NNS
cord-006229-7yoilsho	418	13	in	in	IN
cord-006229-7yoilsho	418	14	hypertensive	hypertensive	JJ
cord-006229-7yoilsho	418	15	heart	heart	NN
cord-006229-7yoilsho	418	16	vs.	vs.	IN
cord-006229-7yoilsho	418	17	kidney	kidney	NN
cord-006229-7yoilsho	418	18	disease	disease	NN
cord-006229-7yoilsho	418	19	.	.	.
cord-006229-7yoilsho	419	1	Platelets	platelet	NNS
cord-006229-7yoilsho	419	2	are	be	VBP
cord-006229-7yoilsho	419	3	relevant	relevant	JJ
cord-006229-7yoilsho	419	4	cells	cell	NNS
cord-006229-7yoilsho	419	5	implicated	implicate	VBN
cord-006229-7yoilsho	419	6	in	in	IN
cord-006229-7yoilsho	419	7	morbidity	morbidity	NN
cord-006229-7yoilsho	419	8	and	and	CC
cord-006229-7yoilsho	419	9	mortality	mortality	NN
cord-006229-7yoilsho	419	10	provoked	provoke	VBN
cord-006229-7yoilsho	419	11	by	by	IN
cord-006229-7yoilsho	419	12	cardiovascular	cardiovascular	JJ
cord-006229-7yoilsho	419	13	thrombosis	thrombosis	NN
cord-006229-7yoilsho	419	14	.	.	.
cord-006229-7yoilsho	420	1	Even	even	RB
cord-006229-7yoilsho	420	2	with	with	IN
cord-006229-7yoilsho	420	3	the	the	DT
cord-006229-7yoilsho	420	4	actual	actual	JJ
cord-006229-7yoilsho	420	5	antiplatelet	antiplatelet	NN
cord-006229-7yoilsho	420	6	therapy	therapy	NN
cord-006229-7yoilsho	420	7	there	there	EX
cord-006229-7yoilsho	420	8	is	be	VBZ
cord-006229-7yoilsho	420	9	still	still	RB
cord-006229-7yoilsho	420	10	a	a	DT
cord-006229-7yoilsho	420	11	substantial	substantial	JJ
cord-006229-7yoilsho	420	12	incidence	incidence	NN
cord-006229-7yoilsho	420	13	of	of	IN
cord-006229-7yoilsho	420	14	arterial	arterial	JJ
cord-006229-7yoilsho	420	15	thrombosis	thrombosis	NN
cord-006229-7yoilsho	420	16	.	.	.
cord-006229-7yoilsho	421	1	Therefore	therefore	RB
cord-006229-7yoilsho	421	2	,	,	,
cord-006229-7yoilsho	421	3	a	a	DT
cord-006229-7yoilsho	421	4	better	well	JJR
cord-006229-7yoilsho	421	5	understanding	understanding	NN
cord-006229-7yoilsho	421	6	of	of	IN
cord-006229-7yoilsho	421	7	the	the	DT
cord-006229-7yoilsho	421	8	mechanisms	mechanism	NNS
cord-006229-7yoilsho	421	9	involved	involve	VBN
cord-006229-7yoilsho	421	10	in	in	IN
cord-006229-7yoilsho	421	11	platelet	platelet	NN
cord-006229-7yoilsho	421	12	activation	activation	NN
cord-006229-7yoilsho	421	13	and	and	CC
cord-006229-7yoilsho	421	14	aggregation	aggregation	NN
cord-006229-7yoilsho	421	15	is	be	VBZ
cord-006229-7yoilsho	421	16	required	require	VBN
cord-006229-7yoilsho	421	17	to	to	TO
cord-006229-7yoilsho	421	18	develop	develop	VB
cord-006229-7yoilsho	421	19	improved	improve	VBN
cord-006229-7yoilsho	421	20	antiplatelet	antiplatelet	JJ
cord-006229-7yoilsho	421	21	therapies	therapy	NNS
cord-006229-7yoilsho	421	22	.	.	.
cord-006229-7yoilsho	422	1	The	the	DT
cord-006229-7yoilsho	422	2	increase	increase	NN
cord-006229-7yoilsho	422	3	in	in	IN
cord-006229-7yoilsho	422	4	the	the	DT
cord-006229-7yoilsho	422	5	intracellular	intracellular	JJ
cord-006229-7yoilsho	422	6	Ca	Ca	NNP
cord-006229-7yoilsho	422	7	2	2	CD
cord-006229-7yoilsho	422	8	+	+	CC
cord-006229-7yoilsho	422	9	concentration	concentration	NN
cord-006229-7yoilsho	422	10	due	due	JJ
cord-006229-7yoilsho	422	11	to	to	IN
cord-006229-7yoilsho	422	12	Ca	Ca	NNP
cord-006229-7yoilsho	422	13	2	2	CD
cord-006229-7yoilsho	422	14	+	+	CC
cord-006229-7yoilsho	422	15	entry	entry	NN
cord-006229-7yoilsho	422	16	from	from	IN
cord-006229-7yoilsho	422	17	the	the	DT
cord-006229-7yoilsho	422	18	extracellular	extracellular	JJ
cord-006229-7yoilsho	422	19	space	space	NN
cord-006229-7yoilsho	422	20	is	be	VBZ
cord-006229-7yoilsho	422	21	critical	critical	JJ
cord-006229-7yoilsho	422	22	for	for	IN
cord-006229-7yoilsho	422	23	platelet	platelet	NN
cord-006229-7yoilsho	422	24	activation	activation	NN
cord-006229-7yoilsho	422	25	and	and	CC
cord-006229-7yoilsho	422	26	aggregation	aggregation	NN
cord-006229-7yoilsho	422	27	.	.	.
cord-006229-7yoilsho	423	1	Ca	ca	NN
cord-006229-7yoilsho	423	2	2	2	CD
cord-006229-7yoilsho	423	3	+	+	CC
cord-006229-7yoilsho	423	4	entry	entry	NN
cord-006229-7yoilsho	423	5	follows	follow	VBZ
cord-006229-7yoilsho	423	6	activation	activation	NN
cord-006229-7yoilsho	423	7	of	of	IN
cord-006229-7yoilsho	423	8	plasma	plasma	NN
cord-006229-7yoilsho	423	9	membrane	membrane	NN
cord-006229-7yoilsho	423	10	receptors	receptor	NNS
cord-006229-7yoilsho	423	11	including	include	VBG
cord-006229-7yoilsho	423	12	Gqcoupled	Gqcoupled	NNP
cord-006229-7yoilsho	423	13	receptors	receptor	NNS
cord-006229-7yoilsho	423	14	for	for	IN
cord-006229-7yoilsho	423	15	ADP	ADP	NNP
cord-006229-7yoilsho	423	16	,	,	,
cord-006229-7yoilsho	424	1	Thromboxane	Thromboxane	NNP
cord-006229-7yoilsho	424	2	A	a	DT
cord-006229-7yoilsho	424	3	2	2	CD
cord-006229-7yoilsho	424	4	(	(	-LRB-
cord-006229-7yoilsho	424	5	TxA	TxA	NNP
cord-006229-7yoilsho	424	6	2	2	CD
cord-006229-7yoilsho	424	7	)	)	-RRB-
cord-006229-7yoilsho	424	8	or	or	CC
cord-006229-7yoilsho	424	9	thrombin	thrombin	NN
cord-006229-7yoilsho	424	10	,	,	,
cord-006229-7yoilsho	424	11	as	as	RB
cord-006229-7yoilsho	424	12	well	well	RB
cord-006229-7yoilsho	424	13	as	as	IN
cord-006229-7yoilsho	424	14	the	the	DT
cord-006229-7yoilsho	424	15	collagen	collagen	NN
cord-006229-7yoilsho	424	16	receptor	receptor	NN
cord-006229-7yoilsho	424	17	glycoprotein	glycoprotein	NN
cord-006229-7yoilsho	424	18	VI	VI	NNP
cord-006229-7yoilsho	424	19	(	(	-LRB-
cord-006229-7yoilsho	424	20	GPVI	GPVI	NNP
cord-006229-7yoilsho	424	21	)	)	-RRB-
cord-006229-7yoilsho	424	22	.	.	.
cord-006229-7yoilsho	425	1	The	the	DT
cord-006229-7yoilsho	425	2	cellular	cellular	JJ
cord-006229-7yoilsho	425	3	signalling	signal	VBG
cord-006229-7yoilsho	425	4	pathways	pathway	NNS
cord-006229-7yoilsho	425	5	downstream	downstream	IN
cord-006229-7yoilsho	425	6	these	these	DT
cord-006229-7yoilsho	425	7	receptors	receptor	NNS
cord-006229-7yoilsho	425	8	involve	involve	VBP
cord-006229-7yoilsho	425	9	activation	activation	NN
cord-006229-7yoilsho	425	10	of	of	IN
cord-006229-7yoilsho	425	11	Phospholipase	Phospholipase	NNP
cord-006229-7yoilsho	425	12	C	C	NNP
cord-006229-7yoilsho	425	13	and	and	CC
cord-006229-7yoilsho	425	14	second	second	JJ
cord-006229-7yoilsho	425	15	messengers	messenger	NNS
cord-006229-7yoilsho	425	16	that	that	WDT
cord-006229-7yoilsho	425	17	are	be	VBP
cord-006229-7yoilsho	425	18	known	know	VBN
cord-006229-7yoilsho	425	19	to	to	TO
cord-006229-7yoilsho	425	20	mediate	mediate	VB
cord-006229-7yoilsho	425	21	activation	activation	NN
cord-006229-7yoilsho	425	22	of	of	IN
cord-006229-7yoilsho	425	23	TRPC	TRPC	NNP
cord-006229-7yoilsho	425	24	channels	channel	NNS
cord-006229-7yoilsho	425	25	.	.	.
cord-006229-7yoilsho	426	1	TRPC	TRPC	NNP
cord-006229-7yoilsho	426	2	proteins	protein	NNS
cord-006229-7yoilsho	426	3	form	form	VBP
cord-006229-7yoilsho	426	4	receptor	receptor	NN
cord-006229-7yoilsho	426	5	-	-	HYPH
cord-006229-7yoilsho	426	6	operated	operate	VBN
cord-006229-7yoilsho	426	7	cation	cation	NN
cord-006229-7yoilsho	426	8	channels	channel	NNS
cord-006229-7yoilsho	426	9	,	,	,
cord-006229-7yoilsho	426	10	but	but	CC
cord-006229-7yoilsho	426	11	their	-PRON-	PRP$
cord-006229-7yoilsho	426	12	regulation	regulation	NN
cord-006229-7yoilsho	426	13	and	and	CC
cord-006229-7yoilsho	426	14	permeability	permeability	NN
cord-006229-7yoilsho	426	15	differ	differ	VBP
cord-006229-7yoilsho	426	16	depending	depend	VBG
cord-006229-7yoilsho	426	17	on	on	IN
cord-006229-7yoilsho	426	18	the	the	DT
cord-006229-7yoilsho	426	19	cell	cell	NN
cord-006229-7yoilsho	426	20	type	type	NN
cord-006229-7yoilsho	426	21	.	.	.
cord-006229-7yoilsho	427	1	It	-PRON-	PRP
cord-006229-7yoilsho	427	2	has	have	VBZ
cord-006229-7yoilsho	427	3	been	be	VBN
cord-006229-7yoilsho	427	4	proposed	propose	VBN
cord-006229-7yoilsho	427	5	that	that	IN
cord-006229-7yoilsho	427	6	TRPC	TRPC	NNP
cord-006229-7yoilsho	427	7	proteins	protein	NNS
cord-006229-7yoilsho	427	8	might	may	MD
cord-006229-7yoilsho	427	9	contribute	contribute	VB
cord-006229-7yoilsho	427	10	to	to	IN
cord-006229-7yoilsho	427	11	platelet	platelet	NN
cord-006229-7yoilsho	427	12	function	function	NN
cord-006229-7yoilsho	427	13	as	as	IN
cord-006229-7yoilsho	427	14	constituents	constituent	NNS
cord-006229-7yoilsho	427	15	of	of	IN
cord-006229-7yoilsho	427	16	agonist	agonist	NN
cord-006229-7yoilsho	427	17	-	-	HYPH
cord-006229-7yoilsho	427	18	activated	activate	VBN
cord-006229-7yoilsho	428	1	Ca	ca	NN
cord-006229-7yoilsho	428	2	2	2	CD
cord-006229-7yoilsho	428	3	+	+	CC
cord-006229-7yoilsho	428	4	entry	entry	NN
cord-006229-7yoilsho	428	5	channels	channel	NNS
cord-006229-7yoilsho	428	6	;	;	:
cord-006229-7yoilsho	428	7	however	however	RB
cord-006229-7yoilsho	428	8	,	,	,
cord-006229-7yoilsho	428	9	the	the	DT
cord-006229-7yoilsho	428	10	experimental	experimental	JJ
cord-006229-7yoilsho	428	11	approaches	approach	NNS
cord-006229-7yoilsho	428	12	used	use	VBN
cord-006229-7yoilsho	428	13	so	so	RB
cord-006229-7yoilsho	428	14	far	far	RB
cord-006229-7yoilsho	428	15	and	and	CC
cord-006229-7yoilsho	428	16	the	the	DT
cord-006229-7yoilsho	428	17	lack	lack	NN
cord-006229-7yoilsho	428	18	of	of	IN
cord-006229-7yoilsho	428	19	specific	specific	JJ
cord-006229-7yoilsho	428	20	agonists	agonist	NNS
cord-006229-7yoilsho	428	21	or	or	CC
cord-006229-7yoilsho	428	22	antagonists	antagonist	NNS
cord-006229-7yoilsho	428	23	have	have	VBP
cord-006229-7yoilsho	428	24	not	not	RB
cord-006229-7yoilsho	428	25	allowed	allow	VBN
cord-006229-7yoilsho	428	26	to	to	TO
cord-006229-7yoilsho	428	27	determine	determine	VB
cord-006229-7yoilsho	428	28	the	the	DT
cord-006229-7yoilsho	428	29	individual	individual	JJ
cord-006229-7yoilsho	428	30	contribution	contribution	NN
cord-006229-7yoilsho	428	31	of	of	IN
cord-006229-7yoilsho	428	32	TRPC	TRPC	NNP
cord-006229-7yoilsho	428	33	proteins	protein	NNS
cord-006229-7yoilsho	428	34	for	for	IN
cord-006229-7yoilsho	429	1	agonist	agonist	NN
cord-006229-7yoilsho	429	2	-	-	HYPH
cord-006229-7yoilsho	429	3	induced	induce	VBN
cord-006229-7yoilsho	429	4	Ca	Ca	NNP
cord-006229-7yoilsho	429	5	2	2	CD
cord-006229-7yoilsho	429	6	+	+	CC
cord-006229-7yoilsho	429	7	entry	entry	NN
cord-006229-7yoilsho	429	8	in	in	IN
cord-006229-7yoilsho	429	9	platelets	platelet	NNS
cord-006229-7yoilsho	429	10	,	,	,
cord-006229-7yoilsho	429	11	aggregation	aggregation	NN
cord-006229-7yoilsho	429	12	and	and	CC
cord-006229-7yoilsho	429	13	thrombosis	thrombosis	NN
cord-006229-7yoilsho	429	14	formation	formation	NN
cord-006229-7yoilsho	429	15	.	.	.
cord-006229-7yoilsho	430	1	We	-PRON-	PRP
cord-006229-7yoilsho	430	2	detected	detect	VBD
cord-006229-7yoilsho	430	3	the	the	DT
cord-006229-7yoilsho	430	4	expression	expression	NN
cord-006229-7yoilsho	430	5	of	of	IN
cord-006229-7yoilsho	430	6	TRPC3	TRPC3	NNS
cord-006229-7yoilsho	430	7	and	and	CC
cord-006229-7yoilsho	430	8	TRPC6	TRPC6	VBN
cord-006229-7yoilsho	430	9	in	in	IN
cord-006229-7yoilsho	430	10	human	human	NN
cord-006229-7yoilsho	430	11	and	and	CC
cord-006229-7yoilsho	430	12	mouse	mouse	NN
cord-006229-7yoilsho	430	13	platelets	platelet	NNS
cord-006229-7yoilsho	430	14	.	.	.
cord-006229-7yoilsho	431	1	We	-PRON-	PRP
cord-006229-7yoilsho	431	2	identified	identify	VBD
cord-006229-7yoilsho	431	3	that	that	IN
cord-006229-7yoilsho	431	4	those	those	DT
cord-006229-7yoilsho	431	5	proteins	protein	NNS
cord-006229-7yoilsho	431	6	together	together	RB
cord-006229-7yoilsho	431	7	are	be	VBP
cord-006229-7yoilsho	431	8	essential	essential	JJ
cord-006229-7yoilsho	431	9	components	component	NNS
cord-006229-7yoilsho	431	10	of	of	IN
cord-006229-7yoilsho	431	11	a	a	DT
cord-006229-7yoilsho	431	12	system	system	NN
cord-006229-7yoilsho	431	13	of	of	IN
cord-006229-7yoilsho	431	14	coincidence	coincidence	NN
cord-006229-7yoilsho	431	15	detection	detection	NN
cord-006229-7yoilsho	431	16	in	in	IN
cord-006229-7yoilsho	431	17	cellular	cellular	NN
cord-006229-7yoilsho	432	1	Ca	ca	NN
cord-006229-7yoilsho	432	2	2	2	CD
cord-006229-7yoilsho	432	3	+	+	CC
cord-006229-7yoilsho	432	4	signalling	signalling	NN
cord-006229-7yoilsho	432	5	.	.	.
cord-006229-7yoilsho	433	1	This	this	DT
cord-006229-7yoilsho	433	2	coincidence	coincidence	NN
cord-006229-7yoilsho	433	3	detection	detection	NN
cord-006229-7yoilsho	433	4	triggered	trigger	VBN
cord-006229-7yoilsho	433	5	by	by	IN
cord-006229-7yoilsho	433	6	simultaneous	simultaneous	JJ
cord-006229-7yoilsho	433	7	stimulation	stimulation	NN
cord-006229-7yoilsho	433	8	of	of	IN
cord-006229-7yoilsho	433	9	both	both	DT
cord-006229-7yoilsho	433	10	thrombin	thrombin	NN
cord-006229-7yoilsho	433	11	and	and	CC
cord-006229-7yoilsho	433	12	collagen	collagen	NN
cord-006229-7yoilsho	433	13	receptors	receptor	NNS
cord-006229-7yoilsho	433	14	is	be	VBZ
cord-006229-7yoilsho	433	15	required	require	VBN
cord-006229-7yoilsho	433	16	for	for	IN
cord-006229-7yoilsho	433	17	the	the	DT
cord-006229-7yoilsho	433	18	Phosphatidylserine	Phosphatidylserine	NNP
cord-006229-7yoilsho	433	19	exposure	exposure	NN
cord-006229-7yoilsho	433	20	in	in	IN
cord-006229-7yoilsho	433	21	human	human	JJ
cord-006229-7yoilsho	433	22	and	and	CC
cord-006229-7yoilsho	433	23	murine	murine	JJ
cord-006229-7yoilsho	433	24	platelets	platelet	NNS
cord-006229-7yoilsho	433	25	,	,	,
cord-006229-7yoilsho	433	26	indicating	indicate	VBG
cord-006229-7yoilsho	433	27	the	the	DT
cord-006229-7yoilsho	433	28	role	role	NN
cord-006229-7yoilsho	433	29	of	of	IN
cord-006229-7yoilsho	433	30	TRPC3	TRPC3	NNP
cord-006229-7yoilsho	433	31	/	/	SYM
cord-006229-7yoilsho	433	32	C6	c6	NN
cord-006229-7yoilsho	433	33	proteins	protein	NNS
cord-006229-7yoilsho	433	34	for	for	IN
cord-006229-7yoilsho	433	35	procoagulant	procoagulant	JJ
cord-006229-7yoilsho	433	36	activity	activity	NN
cord-006229-7yoilsho	433	37	.	.	.
cord-006229-7yoilsho	434	1	In	in	IN
cord-006229-7yoilsho	434	2	addition	addition	NN
cord-006229-7yoilsho	434	3	,	,	,
cord-006229-7yoilsho	434	4	we	-PRON-	PRP
cord-006229-7yoilsho	434	5	detected	detect	VBD
cord-006229-7yoilsho	434	6	the	the	DT
cord-006229-7yoilsho	434	7	expression	expression	NN
cord-006229-7yoilsho	434	8	of	of	IN
cord-006229-7yoilsho	434	9	S12	S12	NNP
cord-006229-7yoilsho	434	10	TRPC1	trpc1	NN
cord-006229-7yoilsho	434	11	transcripts	transcript	NNS
cord-006229-7yoilsho	434	12	in	in	IN
cord-006229-7yoilsho	434	13	mouse	mouse	NN
cord-006229-7yoilsho	434	14	platelets	platelet	NNS
cord-006229-7yoilsho	434	15	.	.	.
cord-006229-7yoilsho	435	1	Therefore	therefore	RB
cord-006229-7yoilsho	435	2	,	,	,
cord-006229-7yoilsho	435	3	we	-PRON-	PRP
cord-006229-7yoilsho	435	4	tested	test	VBD
cord-006229-7yoilsho	435	5	TRPC1	TRPC1	NNP
cord-006229-7yoilsho	435	6	/	/	SYM
cord-006229-7yoilsho	435	7	C3	C3	NNP
cord-006229-7yoilsho	435	8	/	/	SYM
cord-006229-7yoilsho	435	9	C6-deficient	C6-deficient	NNP
cord-006229-7yoilsho	435	10	mice	mouse	NNS
cord-006229-7yoilsho	435	11	in	in	IN
cord-006229-7yoilsho	435	12	an	an	DT
cord-006229-7yoilsho	435	13	in	in	IN
cord-006229-7yoilsho	435	14	vivo	vivo	NN
cord-006229-7yoilsho	435	15	model	model	NN
cord-006229-7yoilsho	435	16	of	of	IN
cord-006229-7yoilsho	435	17	arterial	arterial	JJ
cord-006229-7yoilsho	435	18	thrombosis	thrombosis	NN
cord-006229-7yoilsho	435	19	where	where	WRB
cord-006229-7yoilsho	435	20	they	-PRON-	PRP
cord-006229-7yoilsho	435	21	showed	show	VBD
cord-006229-7yoilsho	435	22	reduced	reduced	JJ
cord-006229-7yoilsho	435	23	thrombus	thrombus	NN
cord-006229-7yoilsho	435	24	formation	formation	NN
cord-006229-7yoilsho	435	25	.	.	.
cord-006229-7yoilsho	436	1	Regardless	regardless	RB
cord-006229-7yoilsho	436	2	of	of	IN
cord-006229-7yoilsho	436	3	the	the	DT
cord-006229-7yoilsho	436	4	protective	protective	JJ
cord-006229-7yoilsho	436	5	effect	effect	NN
cord-006229-7yoilsho	436	6	of	of	IN
cord-006229-7yoilsho	436	7	TRPC1	TRPC1	NNP
cord-006229-7yoilsho	436	8	/	/	SYM
cord-006229-7yoilsho	436	9	C3	C3	NNP
cord-006229-7yoilsho	436	10	/	/	SYM
cord-006229-7yoilsho	436	11	C6	C6	NNP
cord-006229-7yoilsho	436	12	inactivation	inactivation	NN
cord-006229-7yoilsho	436	13	observed	observe	VBN
cord-006229-7yoilsho	436	14	in	in	IN
cord-006229-7yoilsho	436	15	the	the	DT
cord-006229-7yoilsho	436	16	thrombosis	thrombosis	NN
cord-006229-7yoilsho	436	17	model	model	NN
cord-006229-7yoilsho	436	18	,	,	,
cord-006229-7yoilsho	436	19	no	no	DT
cord-006229-7yoilsho	436	20	differences	difference	NNS
cord-006229-7yoilsho	436	21	were	be	VBD
cord-006229-7yoilsho	436	22	detected	detect	VBN
cord-006229-7yoilsho	436	23	in	in	IN
cord-006229-7yoilsho	436	24	tail	tail	NN
cord-006229-7yoilsho	436	25	bleeding	bleeding	NN
cord-006229-7yoilsho	436	26	.	.	.
cord-006229-7yoilsho	437	1	To	to	TO
cord-006229-7yoilsho	437	2	evaluate	evaluate	VB
cord-006229-7yoilsho	437	3	the	the	DT
cord-006229-7yoilsho	437	4	relevance	relevance	NN
cord-006229-7yoilsho	437	5	of	of	IN
cord-006229-7yoilsho	437	6	these	these	DT
cord-006229-7yoilsho	437	7	TRPC	TRPC	NNP
cord-006229-7yoilsho	437	8	proteins	protein	NNS
cord-006229-7yoilsho	437	9	in	in	IN
cord-006229-7yoilsho	437	10	platelet	platelet	NN
cord-006229-7yoilsho	437	11	aggregation	aggregation	NN
cord-006229-7yoilsho	437	12	we	-PRON-	PRP
cord-006229-7yoilsho	437	13	measured	measure	VBD
cord-006229-7yoilsho	437	14	in	in	IN
cord-006229-7yoilsho	437	15	vitro	vitro	FW
cord-006229-7yoilsho	437	16	platelet	platelet	NN
cord-006229-7yoilsho	437	17	aggregation	aggregation	NN
cord-006229-7yoilsho	437	18	in	in	IN
cord-006229-7yoilsho	437	19	platelets	platelet	NNS
cord-006229-7yoilsho	437	20	from	from	IN
cord-006229-7yoilsho	437	21	TRPC1	TRPC1	NNP
cord-006229-7yoilsho	437	22	/	/	SYM
cord-006229-7yoilsho	437	23	C3	C3	NNP
cord-006229-7yoilsho	437	24	/	/	SYM
cord-006229-7yoilsho	437	25	C6-deficient	C6-deficient	NNP
cord-006229-7yoilsho	437	26	mice	mouse	NNS
cord-006229-7yoilsho	438	1	and	and	CC
cord-006229-7yoilsho	438	2	we	-PRON-	PRP
cord-006229-7yoilsho	438	3	observed	observe	VBD
cord-006229-7yoilsho	438	4	that	that	IN
cord-006229-7yoilsho	438	5	the	the	DT
cord-006229-7yoilsho	438	6	aggregation	aggregation	NN
cord-006229-7yoilsho	438	7	was	be	VBD
cord-006229-7yoilsho	438	8	reduced	reduce	VBN
cord-006229-7yoilsho	438	9	after	after	IN
cord-006229-7yoilsho	438	10	ADP	ADP	NNP
cord-006229-7yoilsho	438	11	(	(	-LRB-
cord-006229-7yoilsho	438	12	3µM	3µm	CD
cord-006229-7yoilsho	438	13	)	)	-RRB-
cord-006229-7yoilsho	438	14	or	or	CC
cord-006229-7yoilsho	438	15	TxA	txa	NN
cord-006229-7yoilsho	438	16	2	2	CD
cord-006229-7yoilsho	438	17	-analogue	-analogue	:
cord-006229-7yoilsho	438	18	(	(	-LRB-
cord-006229-7yoilsho	438	19	1µM	1µm	CD
cord-006229-7yoilsho	438	20	)	)	-RRB-
cord-006229-7yoilsho	438	21	stimulation	stimulation	NN
cord-006229-7yoilsho	438	22	,	,	,
cord-006229-7yoilsho	438	23	but	but	CC
cord-006229-7yoilsho	438	24	not	not	RB
cord-006229-7yoilsho	438	25	after	after	IN
cord-006229-7yoilsho	438	26	collagen	collagen	NN
cord-006229-7yoilsho	438	27	stimulation	stimulation	NN
cord-006229-7yoilsho	438	28	(	(	-LRB-
cord-006229-7yoilsho	438	29	10µg	10µg	NN
cord-006229-7yoilsho	438	30	/	/	SYM
cord-006229-7yoilsho	438	31	ml	ml	NN
cord-006229-7yoilsho	438	32	)	)	-RRB-
cord-006229-7yoilsho	438	33	.	.	.
cord-006229-7yoilsho	439	1	We	-PRON-	PRP
cord-006229-7yoilsho	439	2	are	be	VBP
cord-006229-7yoilsho	439	3	currently	currently	RB
cord-006229-7yoilsho	439	4	analyzing	analyze	VBG
cord-006229-7yoilsho	439	5	the	the	DT
cord-006229-7yoilsho	439	6	in	in	FW
cord-006229-7yoilsho	439	7	vitro	vitro	FW
cord-006229-7yoilsho	439	8	aggregation	aggregation	NN
cord-006229-7yoilsho	439	9	and	and	CC
cord-006229-7yoilsho	439	10	the	the	DT
cord-006229-7yoilsho	439	11	agonist	agonist	NN
cord-006229-7yoilsho	439	12	-	-	HYPH
cord-006229-7yoilsho	439	13	evoked	evoke	VBN
cord-006229-7yoilsho	439	14	Ca	Ca	NNP
cord-006229-7yoilsho	439	15	2	2	CD
cord-006229-7yoilsho	439	16	+	+	CC
cord-006229-7yoilsho	439	17	response	response	NN
cord-006229-7yoilsho	439	18	in	in	IN
cord-006229-7yoilsho	439	19	platelets	platelet	NNS
cord-006229-7yoilsho	439	20	from	from	IN
cord-006229-7yoilsho	439	21	different	different	JJ
cord-006229-7yoilsho	439	22	TRPC	trpc	NN
cord-006229-7yoilsho	439	23	-	-	HYPH
cord-006229-7yoilsho	439	24	compound	compound	NN
cord-006229-7yoilsho	439	25	and	and	CC
cord-006229-7yoilsho	439	26	single	single	JJ
cord-006229-7yoilsho	439	27	deficient	deficient	JJ
cord-006229-7yoilsho	439	28	mouse	mouse	NN
cord-006229-7yoilsho	439	29	lines	line	NNS
cord-006229-7yoilsho	439	30	to	to	TO
cord-006229-7yoilsho	439	31	understand	understand	VB
cord-006229-7yoilsho	439	32	the	the	DT
cord-006229-7yoilsho	439	33	mechanisms	mechanism	NNS
cord-006229-7yoilsho	439	34	behind	behind	IN
cord-006229-7yoilsho	439	35	this	this	DT
cord-006229-7yoilsho	439	36	phenotype	phenotype	NN
cord-006229-7yoilsho	439	37	with	with	IN
cord-006229-7yoilsho	439	38	regard	regard	NN
cord-006229-7yoilsho	439	39	to	to	IN
cord-006229-7yoilsho	439	40	its	-PRON-	PRP$
cord-006229-7yoilsho	439	41	complementarity	complementarity	NN
cord-006229-7yoilsho	439	42	to	to	IN
cord-006229-7yoilsho	439	43	actual	actual	JJ
cord-006229-7yoilsho	439	44	antiplatelet	antiplatelet	NN
cord-006229-7yoilsho	439	45	therapy	therapy	NN
cord-006229-7yoilsho	439	46	.	.	.
cord-006229-7yoilsho	440	1	Background	background	NN
cord-006229-7yoilsho	440	2	:	:	:
cord-006229-7yoilsho	441	1	Thrombin	Thrombin	NNP
cord-006229-7yoilsho	441	2	signaling	signaling	NN
cord-006229-7yoilsho	441	3	initiates	initiate	VBZ
cord-006229-7yoilsho	441	4	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	441	5	events	event	NNS
cord-006229-7yoilsho	441	6	directly	directly	RB
cord-006229-7yoilsho	441	7	and	and	CC
cord-006229-7yoilsho	441	8	through	through	IN
cord-006229-7yoilsho	441	9	activation	activation	NN
cord-006229-7yoilsho	441	10	of	of	IN
cord-006229-7yoilsho	441	11	platelets	platelet	NNS
cord-006229-7yoilsho	441	12	.	.	.
cord-006229-7yoilsho	442	1	Endogenous	endogenous	JJ
cord-006229-7yoilsho	442	2	and	and	CC
cord-006229-7yoilsho	442	3	pharmacologic	pharmacologic	JJ
cord-006229-7yoilsho	442	4	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	442	5	of	of	IN
cord-006229-7yoilsho	442	6	thrombin	thrombin	NN
cord-006229-7yoilsho	442	7	are	be	VBP
cord-006229-7yoilsho	442	8	therefore	therefore	RB
cord-006229-7yoilsho	442	9	of	of	IN
cord-006229-7yoilsho	442	10	relevance	relevance	NN
cord-006229-7yoilsho	442	11	during	during	IN
cord-006229-7yoilsho	442	12	atheroprogression	atheroprogression	NN
cord-006229-7yoilsho	442	13	and	and	CC
cord-006229-7yoilsho	442	14	for	for	IN
cord-006229-7yoilsho	442	15	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	442	16	intervention	intervention	NN
cord-006229-7yoilsho	442	17	.	.	.
cord-006229-7yoilsho	443	1	The	the	DT
cord-006229-7yoilsho	443	2	small	small	JJ
cord-006229-7yoilsho	443	3	leucine	leucine	NN
cord-006229-7yoilsho	443	4	-	-	HYPH
cord-006229-7yoilsho	443	5	rich	rich	JJ
cord-006229-7yoilsho	443	6	proteoglycan	proteoglycan	NN
cord-006229-7yoilsho	443	7	biglycan	biglycan	NN
cord-006229-7yoilsho	443	8	(	(	-LRB-
cord-006229-7yoilsho	443	9	BGN	BGN	NNP
cord-006229-7yoilsho	443	10	)	)	-RRB-
cord-006229-7yoilsho	443	11	is	be	VBZ
cord-006229-7yoilsho	443	12	such	such	PDT
cord-006229-7yoilsho	443	13	an	an	DT
cord-006229-7yoilsho	443	14	endogenous	endogenous	JJ
cord-006229-7yoilsho	443	15	thrombin	thrombin	JJ
cord-006229-7yoilsho	443	16	inhibitor	inhibitor	NN
cord-006229-7yoilsho	443	17	that	that	WDT
cord-006229-7yoilsho	443	18	acts	act	VBZ
cord-006229-7yoilsho	443	19	through	through	IN
cord-006229-7yoilsho	443	20	activation	activation	NN
cord-006229-7yoilsho	443	21	of	of	IN
cord-006229-7yoilsho	443	22	heparin	heparin	NN
cord-006229-7yoilsho	443	23	cofactor	cofactor	NN
cord-006229-7yoilsho	443	24	II	II	NNP
cord-006229-7yoilsho	443	25	(	(	-LRB-
cord-006229-7yoilsho	443	26	HCII	HCII	NNP
cord-006229-7yoilsho	443	27	)	)	-RRB-
cord-006229-7yoilsho	443	28	.	.	.
cord-006229-7yoilsho	444	1	Here	here	RB
cord-006229-7yoilsho	444	2	,	,	,
cord-006229-7yoilsho	444	3	the	the	DT
cord-006229-7yoilsho	444	4	effect	effect	NN
cord-006229-7yoilsho	444	5	of	of	IN
cord-006229-7yoilsho	444	6	genetic	genetic	JJ
cord-006229-7yoilsho	444	7	deletion	deletion	NN
cord-006229-7yoilsho	444	8	of	of	IN
cord-006229-7yoilsho	444	9	BGN	BGN	NNP
cord-006229-7yoilsho	444	10	on	on	IN
cord-006229-7yoilsho	444	11	thrombin	thrombin	JJ
cord-006229-7yoilsho	444	12	activity	activity	NN
cord-006229-7yoilsho	444	13	,	,	,
cord-006229-7yoilsho	444	14	inflammation	inflammation	NN
cord-006229-7yoilsho	444	15	and	and	CC
cord-006229-7yoilsho	444	16	atherosclerosis	atherosclerosis	NN
cord-006229-7yoilsho	444	17	was	be	VBD
cord-006229-7yoilsho	444	18	addressed	address	VBN
cord-006229-7yoilsho	444	19	.	.	.
cord-006229-7yoilsho	445	1	Methods	method	NNS
cord-006229-7yoilsho	445	2	and	and	CC
cord-006229-7yoilsho	445	3	Results	result	NNS
cord-006229-7yoilsho	445	4	:	:	:
cord-006229-7yoilsho	445	5	BGN	bgn	NN
cord-006229-7yoilsho	445	6	concentrations	concentration	NNS
cord-006229-7yoilsho	445	7	were	be	VBD
cord-006229-7yoilsho	445	8	elevated	elevate	VBN
cord-006229-7yoilsho	445	9	in	in	IN
cord-006229-7yoilsho	445	10	the	the	DT
cord-006229-7yoilsho	445	11	plasma	plasma	NN
cord-006229-7yoilsho	445	12	of	of	IN
cord-006229-7yoilsho	445	13	patients	patient	NNS
cord-006229-7yoilsho	445	14	with	with	IN
cord-006229-7yoilsho	445	15	acute	acute	JJ
cord-006229-7yoilsho	445	16	coronary	coronary	JJ
cord-006229-7yoilsho	445	17	syndrome	syndrome	NN
cord-006229-7yoilsho	445	18	.	.	.
cord-006229-7yoilsho	446	1	In	in	IN
cord-006229-7yoilsho	446	2	ApoE	ApoE	NNP
cord-006229-7yoilsho	446	3	-/mice	-/mice	NNP
cord-006229-7yoilsho	446	4	,	,	,
cord-006229-7yoilsho	446	5	BGN	BGN	NNP
cord-006229-7yoilsho	446	6	was	be	VBD
cord-006229-7yoilsho	446	7	detected	detect	VBN
cord-006229-7yoilsho	446	8	in	in	IN
cord-006229-7yoilsho	446	9	the	the	DT
cord-006229-7yoilsho	446	10	plasma	plasma	NN
cord-006229-7yoilsho	446	11	as	as	RB
cord-006229-7yoilsho	446	12	well	well	RB
cord-006229-7yoilsho	446	13	as	as	IN
cord-006229-7yoilsho	446	14	in	in	IN
cord-006229-7yoilsho	446	15	the	the	DT
cord-006229-7yoilsho	446	16	glykokalyx	glykokalyx	NN
cord-006229-7yoilsho	446	17	of	of	IN
cord-006229-7yoilsho	446	18	capillaries	capillary	NNS
cord-006229-7yoilsho	446	19	.	.	.
cord-006229-7yoilsho	447	1	Additionally	additionally	RB
cord-006229-7yoilsho	447	2	,	,	,
cord-006229-7yoilsho	447	3	BGN	BGN	NNP
cord-006229-7yoilsho	447	4	expression	expression	NN
cord-006229-7yoilsho	447	5	occurred	occur	VBD
cord-006229-7yoilsho	447	6	in	in	IN
cord-006229-7yoilsho	447	7	the	the	DT
cord-006229-7yoilsho	447	8	subendothelial	subendothelial	JJ
cord-006229-7yoilsho	447	9	matrix	matrix	NN
cord-006229-7yoilsho	447	10	of	of	IN
cord-006229-7yoilsho	447	11	arterioles	arterioles	NNPS
cord-006229-7yoilsho	447	12	as	as	RB
cord-006229-7yoilsho	447	13	well	well	RB
cord-006229-7yoilsho	447	14	as	as	IN
cord-006229-7yoilsho	447	15	in	in	IN
cord-006229-7yoilsho	447	16	atherosclerotic	atherosclerotic	JJ
cord-006229-7yoilsho	447	17	plaques	plaque	NNS
cord-006229-7yoilsho	447	18	.	.	.
cord-006229-7yoilsho	448	1	In	in	IN
cord-006229-7yoilsho	448	2	line	line	NN
cord-006229-7yoilsho	448	3	with	with	IN
cord-006229-7yoilsho	448	4	a	a	DT
cord-006229-7yoilsho	448	5	role	role	NN
cord-006229-7yoilsho	448	6	of	of	IN
cord-006229-7yoilsho	448	7	BGN	BGN	NNP
cord-006229-7yoilsho	448	8	in	in	IN
cord-006229-7yoilsho	448	9	balancing	balance	VBG
cord-006229-7yoilsho	448	10	thrombin	thrombin	JJ
cord-006229-7yoilsho	448	11	activity	activity	NN
cord-006229-7yoilsho	448	12	,	,	,
cord-006229-7yoilsho	448	13	ApoE	ApoE	NNPS
cord-006229-7yoilsho	448	14	-/-/Bgn	-/-/bgn	XX
cord-006229-7yoilsho	449	1	-/0	-/0	NNP
cord-006229-7yoilsho	450	1	mice	mouse	NNS
cord-006229-7yoilsho	450	2	exhibited	exhibit	VBD
cord-006229-7yoilsho	450	3	higher	high	JJR
cord-006229-7yoilsho	450	4	activity	activity	NN
cord-006229-7yoilsho	450	5	of	of	IN
cord-006229-7yoilsho	450	6	circulating	circulate	VBG
cord-006229-7yoilsho	450	7	thrombin	thrombin	NN
cord-006229-7yoilsho	450	8	and	and	CC
cord-006229-7yoilsho	450	9	increased	increase	VBN
cord-006229-7yoilsho	450	10	numbers	number	NNS
cord-006229-7yoilsho	450	11	of	of	IN
cord-006229-7yoilsho	450	12	activated	activate	VBN
cord-006229-7yoilsho	450	13	platelets	platelet	NNS
cord-006229-7yoilsho	450	14	than	than	IN
cord-006229-7yoilsho	450	15	did	do	VBD
cord-006229-7yoilsho	450	16	ApoE	ApoE	NNP
cord-006229-7yoilsho	450	17	-/mice	-/mice	VB
cord-006229-7yoilsho	450	18	.	.	.
cord-006229-7yoilsho	451	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	451	2	,	,	,
cord-006229-7yoilsho	451	3	higher	high	JJR
cord-006229-7yoilsho	451	4	concentrations	concentration	NNS
cord-006229-7yoilsho	451	5	of	of	IN
cord-006229-7yoilsho	451	6	circulating	circulate	VBG
cord-006229-7yoilsho	451	7	cytokines	cytokine	NNS
cord-006229-7yoilsho	451	8	in	in	IN
cord-006229-7yoilsho	451	9	ApoE	ApoE	NNS
cord-006229-7yoilsho	452	1	-/-/Bgn	-/-/Bgn	NNP
cord-006229-7yoilsho	453	1	-/0	-/0	NNP
cord-006229-7yoilsho	454	1	mice	mouse	NNS
cord-006229-7yoilsho	454	2	suggested	suggest	VBD
cord-006229-7yoilsho	454	3	a	a	DT
cord-006229-7yoilsho	454	4	pro	pro	JJ
cord-006229-7yoilsho	454	5	-	-	JJ
cord-006229-7yoilsho	454	6	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	454	7	phenotype	phenotype	NN
cord-006229-7yoilsho	454	8	.	.	.
cord-006229-7yoilsho	455	1	Likewise	likewise	RB
cord-006229-7yoilsho	455	2	,	,	,
cord-006229-7yoilsho	455	3	immunohistochemistry	immunohistochemistry	NN
cord-006229-7yoilsho	455	4	and	and	CC
cord-006229-7yoilsho	455	5	FACS	FACS	NNP
cord-006229-7yoilsho	455	6	analysis	analysis	NN
cord-006229-7yoilsho	455	7	of	of	IN
cord-006229-7yoilsho	455	8	the	the	DT
cord-006229-7yoilsho	455	9	aorta	aorta	NN
cord-006229-7yoilsho	455	10	demonstrated	demonstrate	VBD
cord-006229-7yoilsho	455	11	increased	increase	VBN
cord-006229-7yoilsho	455	12	macrophage	macrophage	NN
cord-006229-7yoilsho	455	13	content	content	NN
cord-006229-7yoilsho	455	14	in	in	IN
cord-006229-7yoilsho	455	15	atherosclerotic	atherosclerotic	JJ
cord-006229-7yoilsho	455	16	lesions	lesion	NNS
cord-006229-7yoilsho	455	17	of	of	IN
cord-006229-7yoilsho	455	18	these	these	DT
cord-006229-7yoilsho	455	19	mice	mouse	NNS
cord-006229-7yoilsho	455	20	.	.	.
cord-006229-7yoilsho	456	1	In	in	IN
cord-006229-7yoilsho	456	2	addition	addition	NN
cord-006229-7yoilsho	456	3	,	,	,
cord-006229-7yoilsho	456	4	ApoE	ApoE	NNPS
cord-006229-7yoilsho	456	5	-/-/Bgn	-/-/bgn	XX
cord-006229-7yoilsho	457	1	-/0	-/0	NNP
cord-006229-7yoilsho	458	1	mice	mouse	NNS
cord-006229-7yoilsho	458	2	exhibited	exhibit	VBD
cord-006229-7yoilsho	458	3	higher	high	JJR
cord-006229-7yoilsho	458	4	aortic	aortic	JJ
cord-006229-7yoilsho	458	5	plaque	plaque	NN
cord-006229-7yoilsho	458	6	burden	burden	NN
cord-006229-7yoilsho	458	7	and	and	CC
cord-006229-7yoilsho	458	8	larger	large	JJR
cord-006229-7yoilsho	458	9	atherosclerotic	atherosclerotic	JJ
cord-006229-7yoilsho	458	10	lesions	lesion	NNS
cord-006229-7yoilsho	458	11	at	at	IN
cord-006229-7yoilsho	458	12	the	the	DT
cord-006229-7yoilsho	458	13	aortic	aortic	JJ
cord-006229-7yoilsho	458	14	root	root	NN
cord-006229-7yoilsho	458	15	.	.	.
cord-006229-7yoilsho	459	1	Of	of	IN
cord-006229-7yoilsho	459	2	note	note	NN
cord-006229-7yoilsho	459	3	,	,	,
cord-006229-7yoilsho	459	4	ApoE	ApoE	NNPS
cord-006229-7yoilsho	459	5	-/-/Bgn	-/-/bgn	XX
cord-006229-7yoilsho	460	1	-/0	-/0	NNP
cord-006229-7yoilsho	461	1	mice	mouse	NNS
cord-006229-7yoilsho	461	2	showed	show	VBD
cord-006229-7yoilsho	461	3	progressive	progressive	JJ
cord-006229-7yoilsho	461	4	dilatation	dilatation	NN
cord-006229-7yoilsho	461	5	of	of	IN
cord-006229-7yoilsho	461	6	the	the	DT
cord-006229-7yoilsho	461	7	aortic	aortic	JJ
cord-006229-7yoilsho	461	8	arch	arch	NN
cord-006229-7yoilsho	461	9	corresponding	correspond	VBG
cord-006229-7yoilsho	461	10	to	to	IN
cord-006229-7yoilsho	461	11	a	a	DT
cord-006229-7yoilsho	461	12	decrease	decrease	NN
cord-006229-7yoilsho	461	13	in	in	IN
cord-006229-7yoilsho	461	14	collagen	collagen	NN
cord-006229-7yoilsho	461	15	fibril	fibril	NN
cord-006229-7yoilsho	461	16	density	density	NN
cord-006229-7yoilsho	461	17	suggestive	suggestive	JJ
cord-006229-7yoilsho	461	18	of	of	IN
cord-006229-7yoilsho	461	19	an	an	DT
cord-006229-7yoilsho	461	20	outward	outward	JJ
cord-006229-7yoilsho	461	21	remodelling	remodelling	NN
cord-006229-7yoilsho	461	22	in	in	IN
cord-006229-7yoilsho	461	23	the	the	DT
cord-006229-7yoilsho	461	24	absence	absence	NN
cord-006229-7yoilsho	461	25	of	of	IN
cord-006229-7yoilsho	461	26	BGN	BGN	NNP
cord-006229-7yoilsho	461	27	.	.	.
cord-006229-7yoilsho	462	1	No	no	DT
cord-006229-7yoilsho	462	2	differences	difference	NNS
cord-006229-7yoilsho	462	3	were	be	VBD
cord-006229-7yoilsho	462	4	evident	evident	JJ
cord-006229-7yoilsho	462	5	with	with	IN
cord-006229-7yoilsho	462	6	respect	respect	NN
cord-006229-7yoilsho	462	7	to	to	IN
cord-006229-7yoilsho	462	8	lipid	lipid	NN
cord-006229-7yoilsho	462	9	content	content	NN
cord-006229-7yoilsho	462	10	of	of	IN
cord-006229-7yoilsho	462	11	the	the	DT
cord-006229-7yoilsho	462	12	aortic	aortic	JJ
cord-006229-7yoilsho	462	13	root	root	NN
cord-006229-7yoilsho	462	14	plaques	plaque	NNS
cord-006229-7yoilsho	462	15	or	or	CC
cord-006229-7yoilsho	462	16	circulating	circulate	VBG
cord-006229-7yoilsho	462	17	plasma	plasma	NN
cord-006229-7yoilsho	462	18	lipids	lipid	NNS
cord-006229-7yoilsho	462	19	.	.	.
cord-006229-7yoilsho	463	1	Treatment	treatment	NN
cord-006229-7yoilsho	463	2	with	with	IN
cord-006229-7yoilsho	463	3	the	the	DT
cord-006229-7yoilsho	463	4	thrombin	thrombin	NN
cord-006229-7yoilsho	464	1	inhibitor	inhibitor	NNP
cord-006229-7yoilsho	464	2	argatroban	argatroban	NNP
cord-006229-7yoilsho	464	3	reversed	reverse	VBD
cord-006229-7yoilsho	464	4	platelet	platelet	NN
cord-006229-7yoilsho	464	5	activation	activation	NN
cord-006229-7yoilsho	464	6	and	and	CC
cord-006229-7yoilsho	464	7	aortic	aortic	JJ
cord-006229-7yoilsho	464	8	macrophage	macrophage	NN
cord-006229-7yoilsho	464	9	accumulation	accumulation	NN
cord-006229-7yoilsho	464	10	in	in	IN
cord-006229-7yoilsho	464	11	ApoE	ApoE	NNP
cord-006229-7yoilsho	464	12	-/-/Bgn	-/-/bgn	XX
cord-006229-7yoilsho	465	1	-/0	-/0	NNP
cord-006229-7yoilsho	466	1	mice	mouse	NNS
cord-006229-7yoilsho	466	2	.	.	.
cord-006229-7yoilsho	467	1	Conclusions	conclusion	NNS
cord-006229-7yoilsho	467	2	:	:	:
cord-006229-7yoilsho	468	1	The	the	DT
cord-006229-7yoilsho	468	2	present	present	JJ
cord-006229-7yoilsho	468	3	results	result	NNS
cord-006229-7yoilsho	468	4	strongly	strongly	RB
cord-006229-7yoilsho	468	5	suggest	suggest	VBP
cord-006229-7yoilsho	468	6	a	a	DT
cord-006229-7yoilsho	468	7	protective	protective	JJ
cord-006229-7yoilsho	468	8	role	role	NN
cord-006229-7yoilsho	468	9	of	of	IN
cord-006229-7yoilsho	468	10	BGN	BGN	NNP
cord-006229-7yoilsho	468	11	during	during	IN
cord-006229-7yoilsho	468	12	the	the	DT
cord-006229-7yoilsho	468	13	progression	progression	NN
cord-006229-7yoilsho	468	14	of	of	IN
cord-006229-7yoilsho	468	15	atherosclerosis	atherosclerosis	NN
cord-006229-7yoilsho	468	16	by	by	IN
cord-006229-7yoilsho	468	17	inhibiting	inhibit	VBG
cord-006229-7yoilsho	468	18	thrombin	thrombin	JJ
cord-006229-7yoilsho	468	19	activity	activity	NN
cord-006229-7yoilsho	468	20	and	and	CC
cord-006229-7yoilsho	468	21	platelet	platelet	NN
cord-006229-7yoilsho	468	22	activation	activation	NN
cord-006229-7yoilsho	468	23	,	,	,
cord-006229-7yoilsho	468	24	and	and	CC
cord-006229-7yoilsho	468	25	ultimately	ultimately	RB
cord-006229-7yoilsho	468	26	macrophage	macrophage	NN
cord-006229-7yoilsho	468	27	-	-	HYPH
cord-006229-7yoilsho	468	28	mediated	mediate	VBN
cord-006229-7yoilsho	468	29	plaque	plaque	NN
cord-006229-7yoilsho	468	30	inflammation	inflammation	NN
cord-006229-7yoilsho	468	31	.	.	.
cord-006229-7yoilsho	469	1	The	the	DT
cord-006229-7yoilsho	469	2	exposure	exposure	NN
cord-006229-7yoilsho	469	3	to	to	IN
cord-006229-7yoilsho	469	4	environmental	environmental	JJ
cord-006229-7yoilsho	469	5	or	or	CC
cord-006229-7yoilsho	469	6	human	human	NN
cord-006229-7yoilsho	469	7	-	-	HYPH
cord-006229-7yoilsho	469	8	made	make	VBN
cord-006229-7yoilsho	469	9	xenobiotics	xenobiotic	NNS
cord-006229-7yoilsho	469	10	including	include	VBG
cord-006229-7yoilsho	469	11	drugs	drug	NNS
cord-006229-7yoilsho	469	12	induces	induce	VBZ
cord-006229-7yoilsho	469	13	the	the	DT
cord-006229-7yoilsho	469	14	hepato	hepato	JJ
cord-006229-7yoilsho	469	15	-	-	HYPH
cord-006229-7yoilsho	469	16	intestinal	intestinal	JJ
cord-006229-7yoilsho	469	17	transcription	transcription	NN
cord-006229-7yoilsho	469	18	of	of	IN
cord-006229-7yoilsho	469	19	metabolizing	metabolize	VBG
cord-006229-7yoilsho	469	20	enzymes	enzyme	NNS
cord-006229-7yoilsho	469	21	and	and	CC
cord-006229-7yoilsho	469	22	transporters	transporter	NNS
cord-006229-7yoilsho	469	23	.	.	.
cord-006229-7yoilsho	470	1	The	the	DT
cord-006229-7yoilsho	470	2	time	time	NN
cord-006229-7yoilsho	470	3	-	-	HYPH
cord-006229-7yoilsho	470	4	span	span	NN
cord-006229-7yoilsho	470	5	of	of	IN
cord-006229-7yoilsho	470	6	induction	induction	NN
cord-006229-7yoilsho	470	7	is	be	VBZ
cord-006229-7yoilsho	470	8	thought	think	VBN
cord-006229-7yoilsho	470	9	not	not	RB
cord-006229-7yoilsho	470	10	to	to	TO
cord-006229-7yoilsho	470	11	exceed	exceed	VB
cord-006229-7yoilsho	470	12	xenobiotic	xenobiotic	JJ
cord-006229-7yoilsho	470	13	exposure	exposure	NN
cord-006229-7yoilsho	470	14	,	,	,
cord-006229-7yoilsho	470	15	in	in	IN
cord-006229-7yoilsho	470	16	order	order	NN
cord-006229-7yoilsho	470	17	to	to	TO
cord-006229-7yoilsho	470	18	minimize	minimize	VB
cord-006229-7yoilsho	470	19	disturbances	disturbance	NNS
cord-006229-7yoilsho	470	20	of	of	IN
cord-006229-7yoilsho	470	21	endobiotic	endobiotic	JJ
cord-006229-7yoilsho	470	22	metabolism	metabolism	NN
cord-006229-7yoilsho	470	23	.	.	.
cord-006229-7yoilsho	471	1	In	in	IN
cord-006229-7yoilsho	471	2	contrast	contrast	NN
cord-006229-7yoilsho	471	3	,	,	,
cord-006229-7yoilsho	471	4	we	-PRON-	PRP
cord-006229-7yoilsho	471	5	find	find	VBP
cord-006229-7yoilsho	471	6	cross	cross	JJ
cord-006229-7yoilsho	471	7	-	-	JJ
cord-006229-7yoilsho	471	8	generational	generational	JJ
cord-006229-7yoilsho	471	9	transmission	transmission	NN
cord-006229-7yoilsho	471	10	of	of	IN
cord-006229-7yoilsho	471	11	the	the	DT
cord-006229-7yoilsho	471	12	induction	induction	NN
cord-006229-7yoilsho	471	13	of	of	IN
cord-006229-7yoilsho	471	14	the	the	DT
cord-006229-7yoilsho	471	15	Phase	phase	NN
cord-006229-7yoilsho	471	16	I	-PRON-	PRP
cord-006229-7yoilsho	471	17	enzyme	enzyme	VBP
cord-006229-7yoilsho	471	18	Cyp2b10	cyp2b10	NN
cord-006229-7yoilsho	471	19	(	(	-LRB-
cord-006229-7yoilsho	471	20	1200-fold	1200-fold	CD
cord-006229-7yoilsho	471	21	in	in	IN
cord-006229-7yoilsho	471	22	females	female	NNS
cord-006229-7yoilsho	471	23	,	,	,
cord-006229-7yoilsho	471	24	700-fold	700-fold	CD
cord-006229-7yoilsho	471	25	in	in	IN
cord-006229-7yoilsho	471	26	males	male	NNS
cord-006229-7yoilsho	471	27	)	)	-RRB-
cord-006229-7yoilsho	471	28	in	in	IN
cord-006229-7yoilsho	471	29	6-day	6-day	JJ
cord-006229-7yoilsho	471	30	old	old	JJ
cord-006229-7yoilsho	471	31	offspring	offspring	NN
cord-006229-7yoilsho	471	32	of	of	IN
cord-006229-7yoilsho	471	33	adult	adult	NN
cord-006229-7yoilsho	471	34	female	female	JJ
cord-006229-7yoilsho	471	35	mice	mouse	NNS
cord-006229-7yoilsho	471	36	exposed	expose	VBD
cord-006229-7yoilsho	471	37	one	one	CD
cord-006229-7yoilsho	471	38	week	week	NN
cord-006229-7yoilsho	471	39	prior	prior	JJ
cord-006229-7yoilsho	471	40	mating	mate	VBG
cord-006229-7yoilsho	471	41	to	to	IN
cord-006229-7yoilsho	471	42	TCPOBOP	TCPOBOP	NNP
cord-006229-7yoilsho	471	43	(	(	-LRB-
cord-006229-7yoilsho	471	44	3	3	CD
cord-006229-7yoilsho	471	45	mg	mg	NNP
cord-006229-7yoilsho	471	46	/	/	SYM
cord-006229-7yoilsho	471	47	kg	kg	NNP
cord-006229-7yoilsho	471	48	i.p	i.p	NNP
cord-006229-7yoilsho	471	49	.	.	NNP
cord-006229-7yoilsho	471	50	)	)	-RRB-
cord-006229-7yoilsho	471	51	,	,	,
cord-006229-7yoilsho	471	52	the	the	DT
cord-006229-7yoilsho	471	53	model	model	NN
cord-006229-7yoilsho	471	54	ligand	ligand	NN
cord-006229-7yoilsho	471	55	of	of	IN
cord-006229-7yoilsho	471	56	the	the	DT
cord-006229-7yoilsho	471	57	xenosensing	xenosense	VBG
cord-006229-7yoilsho	471	58	nuclear	nuclear	JJ
cord-006229-7yoilsho	471	59	receptor	receptor	NN
cord-006229-7yoilsho	471	60	CAR	CAR	NNP
cord-006229-7yoilsho	471	61	.	.	.
cord-006229-7yoilsho	472	1	Such	such	JJ
cord-006229-7yoilsho	472	2	cross	cross	JJ
cord-006229-7yoilsho	472	3	-	-	JJ
cord-006229-7yoilsho	472	4	generational	generational	JJ
cord-006229-7yoilsho	472	5	effects	effect	NNS
cord-006229-7yoilsho	472	6	of	of	IN
cord-006229-7yoilsho	472	7	xenobiotics	xenobiotic	NNS
cord-006229-7yoilsho	472	8	are	be	VBP
cord-006229-7yoilsho	472	9	of	of	IN
cord-006229-7yoilsho	472	10	great	great	JJ
cord-006229-7yoilsho	472	11	clinical	clinical	JJ
cord-006229-7yoilsho	472	12	interest	interest	NN
cord-006229-7yoilsho	472	13	as	as	IN
cord-006229-7yoilsho	472	14	they	-PRON-	PRP
cord-006229-7yoilsho	472	15	could	could	MD
cord-006229-7yoilsho	472	16	have	have	VB
cord-006229-7yoilsho	472	17	profound	profound	JJ
cord-006229-7yoilsho	472	18	consequences	consequence	NNS
cord-006229-7yoilsho	472	19	on	on	IN
cord-006229-7yoilsho	472	20	the	the	DT
cord-006229-7yoilsho	472	21	health	health	NN
cord-006229-7yoilsho	472	22	status	status	NN
cord-006229-7yoilsho	472	23	of	of	IN
cord-006229-7yoilsho	472	24	the	the	DT
cord-006229-7yoilsho	472	25	offspring	offspring	NN
cord-006229-7yoilsho	472	26	,	,	,
cord-006229-7yoilsho	472	27	including	include	VBG
cord-006229-7yoilsho	472	28	interferences	interference	NNS
cord-006229-7yoilsho	472	29	with	with	IN
cord-006229-7yoilsho	472	30	drug	drug	NN
cord-006229-7yoilsho	472	31	therapies	therapy	NNS
cord-006229-7yoilsho	472	32	.	.	.
cord-006229-7yoilsho	473	1	The	the	DT
cord-006229-7yoilsho	473	2	multigenerational	multigenerational	JJ
cord-006229-7yoilsho	473	3	transmission	transmission	NN
cord-006229-7yoilsho	473	4	of	of	IN
cord-006229-7yoilsho	473	5	TCPOBOP	TCPOBOP	NNP
cord-006229-7yoilsho	473	6	-	-	HYPH
cord-006229-7yoilsho	473	7	driven	drive	VBN
cord-006229-7yoilsho	473	8	induction	induction	NN
cord-006229-7yoilsho	473	9	could	could	MD
cord-006229-7yoilsho	473	10	be	be	VB
cord-006229-7yoilsho	473	11	mediated	mediate	VBN
cord-006229-7yoilsho	473	12	by	by	IN
cord-006229-7yoilsho	473	13	pre	pre	JJ
cord-006229-7yoilsho	473	14	-	-	JJ
cord-006229-7yoilsho	473	15	uterine	uterine	JJ
cord-006229-7yoilsho	473	16	/	/	SYM
cord-006229-7yoilsho	473	17	pre	pre	JJ
cord-006229-7yoilsho	473	18	-	-	JJ
cord-006229-7yoilsho	473	19	conceptional	conceptional	JJ
cord-006229-7yoilsho	473	20	epigenetic	epigenetic	JJ
cord-006229-7yoilsho	473	21	changes	change	NNS
cord-006229-7yoilsho	473	22	of	of	IN
cord-006229-7yoilsho	473	23	oocytes	oocyte	NNS
cord-006229-7yoilsho	473	24	.	.	.
cord-006229-7yoilsho	474	1	Alternatively	alternatively	RB
cord-006229-7yoilsho	474	2	,	,	,
cord-006229-7yoilsho	474	3	they	-PRON-	PRP
cord-006229-7yoilsho	474	4	could	could	MD
cord-006229-7yoilsho	474	5	be	be	VB
cord-006229-7yoilsho	474	6	brought	bring	VBN
cord-006229-7yoilsho	474	7	about	about	RP
cord-006229-7yoilsho	474	8	by	by	IN
cord-006229-7yoilsho	474	9	direct	direct	JJ
cord-006229-7yoilsho	474	10	intrauterine	intrauterine	JJ
cord-006229-7yoilsho	474	11	/	/	SYM
cord-006229-7yoilsho	474	12	post	post	JJ
cord-006229-7yoilsho	474	13	-	-	JJ
cord-006229-7yoilsho	474	14	conceptional	conceptional	JJ
cord-006229-7yoilsho	474	15	contact	contact	NN
cord-006229-7yoilsho	474	16	with	with	IN
cord-006229-7yoilsho	474	17	TCPOBOP	TCPOBOP	NNP
cord-006229-7yoilsho	474	18	released	release	VBN
cord-006229-7yoilsho	474	19	from	from	IN
cord-006229-7yoilsho	474	20	long	long	JJ
cord-006229-7yoilsho	474	21	-	-	HYPH
cord-006229-7yoilsho	474	22	term	term	NN
cord-006229-7yoilsho	474	23	depots	depot	NNS
cord-006229-7yoilsho	474	24	.	.	.
cord-006229-7yoilsho	475	1	To	to	TO
cord-006229-7yoilsho	475	2	discriminate	discriminate	VB
cord-006229-7yoilsho	475	3	between	between	IN
cord-006229-7yoilsho	475	4	these	these	DT
cord-006229-7yoilsho	475	5	mechanisms	mechanism	NNS
cord-006229-7yoilsho	475	6	we	-PRON-	PRP
cord-006229-7yoilsho	475	7	conducted	conduct	VBD
cord-006229-7yoilsho	475	8	embryo	embryo	NN
cord-006229-7yoilsho	475	9	transfer	transfer	NN
cord-006229-7yoilsho	475	10	experiments	experiment	NNS
cord-006229-7yoilsho	475	11	.	.	.
cord-006229-7yoilsho	476	1	Both	both	DT
cord-006229-7yoilsho	476	2	donor	donor	NN
cord-006229-7yoilsho	476	3	mothers	mother	NNS
cord-006229-7yoilsho	476	4	and	and	CC
cord-006229-7yoilsho	476	5	foster	foster	JJ
cord-006229-7yoilsho	476	6	mothers	mother	NNS
cord-006229-7yoilsho	476	7	were	be	VBD
cord-006229-7yoilsho	476	8	injected	inject	VBN
cord-006229-7yoilsho	476	9	with	with	IN
cord-006229-7yoilsho	476	10	TCPOBOP	TCPOBOP	NNP
cord-006229-7yoilsho	476	11	(	(	-LRB-
cord-006229-7yoilsho	476	12	3	3	CD
cord-006229-7yoilsho	476	13	mg	mg	NNP
cord-006229-7yoilsho	476	14	/	/	SYM
cord-006229-7yoilsho	476	15	kg	kg	NNP
cord-006229-7yoilsho	476	16	)	)	-RRB-
cord-006229-7yoilsho	476	17	prior	prior	RB
cord-006229-7yoilsho	476	18	to	to	IN
cord-006229-7yoilsho	476	19	mating	mating	NN
cord-006229-7yoilsho	476	20	.	.	.
cord-006229-7yoilsho	477	1	The	the	DT
cord-006229-7yoilsho	477	2	analysis	analysis	NN
cord-006229-7yoilsho	477	3	of	of	IN
cord-006229-7yoilsho	477	4	hepatic	hepatic	JJ
cord-006229-7yoilsho	477	5	Cyp2b10	Cyp2b10	NNP
cord-006229-7yoilsho	477	6	expression	expression	NN
cord-006229-7yoilsho	477	7	in	in	IN
cord-006229-7yoilsho	477	8	6-day	6-day	JJ
cord-006229-7yoilsho	477	9	-	-	HYPH
cord-006229-7yoilsho	477	10	old	old	JJ
cord-006229-7yoilsho	477	11	offspring	offspring	NN
cord-006229-7yoilsho	477	12	is	be	VBZ
cord-006229-7yoilsho	477	13	clearly	clearly	RB
cord-006229-7yoilsho	477	14	consistent	consistent	JJ
cord-006229-7yoilsho	477	15	with	with	IN
cord-006229-7yoilsho	477	16	a	a	DT
cord-006229-7yoilsho	477	17	post	post	JJ
cord-006229-7yoilsho	477	18	-	-	JJ
cord-006229-7yoilsho	477	19	conceptional	conceptional	JJ
cord-006229-7yoilsho	477	20	onset	onset	NN
cord-006229-7yoilsho	477	21	of	of	IN
cord-006229-7yoilsho	477	22	TCPOBOP	TCPOBOP	NNP
cord-006229-7yoilsho	477	23	effects	effect	NNS
cord-006229-7yoilsho	477	24	.	.	.
cord-006229-7yoilsho	478	1	Thus	thus	RB
cord-006229-7yoilsho	478	2	,	,	,
cord-006229-7yoilsho	478	3	offspring	offspring	NN
cord-006229-7yoilsho	478	4	of	of	IN
cord-006229-7yoilsho	478	5	solvent	solvent	NN
cord-006229-7yoilsho	478	6	-	-	HYPH
cord-006229-7yoilsho	478	7	injected	inject	VBN
cord-006229-7yoilsho	478	8	donor	donor	NN
cord-006229-7yoilsho	478	9	mothers	mother	NNS
cord-006229-7yoilsho	478	10	transferred	transfer	VBN
cord-006229-7yoilsho	478	11	to	to	IN
cord-006229-7yoilsho	478	12	TCPOBOPexposed	TCPOBOPexposed	NNP
cord-006229-7yoilsho	478	13	foster	foster	JJ
cord-006229-7yoilsho	478	14	mothers	mother	NNS
cord-006229-7yoilsho	478	15	display	display	VBP
cord-006229-7yoilsho	478	16	a	a	DT
cord-006229-7yoilsho	478	17	700-fold	700-fold	CD
cord-006229-7yoilsho	478	18	induction	induction	NN
cord-006229-7yoilsho	478	19	while	while	IN
cord-006229-7yoilsho	478	20	offspring	offspre	VBG
cord-006229-7yoilsho	478	21	from	from	IN
cord-006229-7yoilsho	478	22	the	the	DT
cord-006229-7yoilsho	478	23	reciprocal	reciprocal	JJ
cord-006229-7yoilsho	478	24	experiment	experiment	NN
cord-006229-7yoilsho	478	25	show	show	VBP
cord-006229-7yoilsho	478	26	no	no	DT
cord-006229-7yoilsho	478	27	changes	change	NNS
cord-006229-7yoilsho	478	28	.	.	.
cord-006229-7yoilsho	479	1	Cesarean	cesarean	JJ
cord-006229-7yoilsho	479	2	sections	section	NNS
cord-006229-7yoilsho	479	3	on	on	IN
cord-006229-7yoilsho	479	4	day	day	NN
cord-006229-7yoilsho	479	5	E18.5	E18.5	NNP
cord-006229-7yoilsho	479	6	followed	follow	VBN
cord-006229-7yoilsho	479	7	by	by	IN
cord-006229-7yoilsho	479	8	crossfostering	crossfostere	VBG
cord-006229-7yoilsho	479	9	proved	prove	VBD
cord-006229-7yoilsho	479	10	transmission	transmission	NN
cord-006229-7yoilsho	479	11	to	to	TO
cord-006229-7yoilsho	479	12	be	be	VB
cord-006229-7yoilsho	479	13	mediated	mediate	VBN
cord-006229-7yoilsho	479	14	predominantly	predominantly	RB
cord-006229-7yoilsho	479	15	via	via	IN
cord-006229-7yoilsho	479	16	lactation	lactation	NN
cord-006229-7yoilsho	479	17	(	(	-LRB-
cord-006229-7yoilsho	479	18	F1	F1	NNP
cord-006229-7yoilsho	479	19	hepatic	hepatic	JJ
cord-006229-7yoilsho	479	20	Cyp2b10	Cyp2b10	NNP
cord-006229-7yoilsho	479	21	induction	induction	NN
cord-006229-7yoilsho	479	22	3000-fold	3000-fold	CD
cord-006229-7yoilsho	479	23	)	)	-RRB-
cord-006229-7yoilsho	479	24	and	and	CC
cord-006229-7yoilsho	479	25	only	only	RB
cord-006229-7yoilsho	479	26	to	to	IN
cord-006229-7yoilsho	479	27	a	a	DT
cord-006229-7yoilsho	479	28	minor	minor	JJ
cord-006229-7yoilsho	479	29	part	part	NN
cord-006229-7yoilsho	479	30	via	via	IN
cord-006229-7yoilsho	479	31	intra	intra	JJ
cord-006229-7yoilsho	479	32	-	-	JJ
cord-006229-7yoilsho	479	33	uterine	uterine	JJ
cord-006229-7yoilsho	479	34	exposure	exposure	NN
cord-006229-7yoilsho	479	35	(	(	-LRB-
cord-006229-7yoilsho	479	36	300fold	300fold	NNP
cord-006229-7yoilsho	479	37	)	)	-RRB-
cord-006229-7yoilsho	479	38	.	.	.
cord-006229-7yoilsho	480	1	This	this	DT
cord-006229-7yoilsho	480	2	mechanism	mechanism	NN
cord-006229-7yoilsho	480	3	is	be	VBZ
cord-006229-7yoilsho	480	4	consistent	consistent	JJ
cord-006229-7yoilsho	480	5	with	with	IN
cord-006229-7yoilsho	480	6	the	the	DT
cord-006229-7yoilsho	480	7	absence	absence	NN
cord-006229-7yoilsho	480	8	of	of	IN
cord-006229-7yoilsho	480	9	induction	induction	NN
cord-006229-7yoilsho	480	10	transmission	transmission	NN
cord-006229-7yoilsho	480	11	via	via	IN
cord-006229-7yoilsho	480	12	the	the	DT
cord-006229-7yoilsho	480	13	male	male	JJ
cord-006229-7yoilsho	480	14	germline	germline	NN
cord-006229-7yoilsho	480	15	.	.	.
cord-006229-7yoilsho	481	1	To	to	TO
cord-006229-7yoilsho	481	2	analyze	analyze	VB
cord-006229-7yoilsho	481	3	if	if	IN
cord-006229-7yoilsho	481	4	TCPOBOP	TCPOBOP	NNP
cord-006229-7yoilsho	481	5	leads	lead	VBZ
cord-006229-7yoilsho	481	6	to	to	IN
cord-006229-7yoilsho	481	7	functional	functional	JJ
cord-006229-7yoilsho	481	8	consequences	consequence	NNS
cord-006229-7yoilsho	481	9	in	in	IN
cord-006229-7yoilsho	481	10	drug	drug	NN
cord-006229-7yoilsho	481	11	metabolism	metabolism	NN
cord-006229-7yoilsho	481	12	of	of	IN
cord-006229-7yoilsho	481	13	F0	f0	NN
cord-006229-7yoilsho	481	14	and	and	CC
cord-006229-7yoilsho	481	15	F1	F1	NNP
cord-006229-7yoilsho	481	16	generation	generation	NN
cord-006229-7yoilsho	481	17	,	,	,
cord-006229-7yoilsho	481	18	we	-PRON-	PRP
cord-006229-7yoilsho	481	19	conducted	conduct	VBD
cord-006229-7yoilsho	481	20	in	in	IN
cord-006229-7yoilsho	481	21	vivo	vivo	NNP
cord-006229-7yoilsho	481	22	zoxazolamine	zoxazolamine	NNP
cord-006229-7yoilsho	481	23	paralysis	paralysis	NN
cord-006229-7yoilsho	481	24	assays	assay	NNS
cord-006229-7yoilsho	481	25	taken	take	VBN
cord-006229-7yoilsho	481	26	as	as	IN
cord-006229-7yoilsho	481	27	a	a	DT
cord-006229-7yoilsho	481	28	functional	functional	JJ
cord-006229-7yoilsho	481	29	test	test	NN
cord-006229-7yoilsho	481	30	for	for	IN
cord-006229-7yoilsho	481	31	Cyp2b10	cyp2b10	JJ
cord-006229-7yoilsho	481	32	catalytic	catalytic	JJ
cord-006229-7yoilsho	481	33	activity	activity	NN
cord-006229-7yoilsho	481	34	.	.	.
cord-006229-7yoilsho	482	1	In	in	IN
cord-006229-7yoilsho	482	2	both	both	DT
cord-006229-7yoilsho	482	3	TCPOBOP	TCPOBOP	NNP
cord-006229-7yoilsho	482	4	-	-	HYPH
cord-006229-7yoilsho	482	5	pretreated	pretreate	VBN
cord-006229-7yoilsho	482	6	F0	f0	NN
cord-006229-7yoilsho	482	7	and	and	CC
cord-006229-7yoilsho	482	8	in	in	IN
cord-006229-7yoilsho	482	9	their	-PRON-	PRP$
cord-006229-7yoilsho	482	10	F1	f1	NN
cord-006229-7yoilsho	482	11	descendants	descendant	NNS
cord-006229-7yoilsho	482	12	,	,	,
cord-006229-7yoilsho	482	13	the	the	DT
cord-006229-7yoilsho	482	14	induction	induction	NN
cord-006229-7yoilsho	482	15	reduced	reduce	VBD
cord-006229-7yoilsho	482	16	the	the	DT
cord-006229-7yoilsho	482	17	duration	duration	NN
cord-006229-7yoilsho	482	18	of	of	IN
cord-006229-7yoilsho	482	19	paralysis	paralysis	NN
cord-006229-7yoilsho	482	20	evoked	evoke	VBN
cord-006229-7yoilsho	482	21	by	by	IN
cord-006229-7yoilsho	482	22	zoxazolamine	zoxazolamine	NNP
cord-006229-7yoilsho	482	23	by	by	IN
cord-006229-7yoilsho	482	24	>	>	XX
cord-006229-7yoilsho	482	25	50	50	CD
cord-006229-7yoilsho	482	26	%	%	NN
cord-006229-7yoilsho	482	27	.	.	.
cord-006229-7yoilsho	483	1	The	the	DT
cord-006229-7yoilsho	483	2	characterization	characterization	NN
cord-006229-7yoilsho	483	3	of	of	IN
cord-006229-7yoilsho	483	4	cross	cross	JJ
cord-006229-7yoilsho	483	5	-	-	JJ
cord-006229-7yoilsho	483	6	generational	generational	JJ
cord-006229-7yoilsho	483	7	TCPOBOP	TCPOBOP	NNP
cord-006229-7yoilsho	483	8	-	-	HYPH
cord-006229-7yoilsho	483	9	mediated	mediate	VBN
cord-006229-7yoilsho	483	10	effects	effect	NNS
cord-006229-7yoilsho	483	11	on	on	IN
cord-006229-7yoilsho	483	12	other	other	JJ
cord-006229-7yoilsho	483	13	processes	process	NNS
cord-006229-7yoilsho	483	14	controlled	control	VBN
cord-006229-7yoilsho	483	15	by	by	IN
cord-006229-7yoilsho	483	16	CAR	car	NN
cord-006229-7yoilsho	483	17	such	such	JJ
cord-006229-7yoilsho	483	18	as	as	IN
cord-006229-7yoilsho	483	19	energy	energy	NN
cord-006229-7yoilsho	483	20	and	and	CC
cord-006229-7yoilsho	483	21	bone	bone	NN
cord-006229-7yoilsho	483	22	metabolism	metabolism	NN
cord-006229-7yoilsho	483	23	is	be	VBZ
cord-006229-7yoilsho	483	24	in	in	IN
cord-006229-7yoilsho	483	25	progress	progress	NN
cord-006229-7yoilsho	483	26	.	.	.
cord-006229-7yoilsho	484	1	First	first	JJ
cord-006229-7yoilsho	484	2	tests	test	NNS
cord-006229-7yoilsho	484	3	indicate	indicate	VBP
cord-006229-7yoilsho	484	4	a	a	DT
cord-006229-7yoilsho	484	5	transmission	transmission	NN
cord-006229-7yoilsho	484	6	of	of	IN
cord-006229-7yoilsho	484	7	anabolic	anabolic	JJ
cord-006229-7yoilsho	484	8	effects	effect	NNS
cord-006229-7yoilsho	484	9	on	on	IN
cord-006229-7yoilsho	484	10	bone	bone	NN
cord-006229-7yoilsho	484	11	,	,	,
cord-006229-7yoilsho	484	12	as	as	IN
cord-006229-7yoilsho	484	13	evidenced	evidence	VBN
cord-006229-7yoilsho	484	14	by	by	IN
cord-006229-7yoilsho	484	15	the	the	DT
cord-006229-7yoilsho	484	16	induction	induction	NN
cord-006229-7yoilsho	484	17	of	of	IN
cord-006229-7yoilsho	484	18	serum	serum	NN
cord-006229-7yoilsho	484	19	osteocalcin	osteocalcin	NN
cord-006229-7yoilsho	484	20	expression	expression	NN
cord-006229-7yoilsho	484	21	by	by	IN
cord-006229-7yoilsho	484	22	45	45	CD
cord-006229-7yoilsho	484	23	%	%	NN
cord-006229-7yoilsho	484	24	in	in	IN
cord-006229-7yoilsho	484	25	12-weeks	12-weeks	CD
cord-006229-7yoilsho	484	26	-	-	HYPH
cord-006229-7yoilsho	484	27	old	old	JJ
cord-006229-7yoilsho	484	28	offspring	offspring	NN
cord-006229-7yoilsho	484	29	.	.	.
cord-006229-7yoilsho	485	1	In	in	IN
cord-006229-7yoilsho	485	2	summary	summary	NN
cord-006229-7yoilsho	485	3	,	,	,
cord-006229-7yoilsho	485	4	the	the	DT
cord-006229-7yoilsho	485	5	CAR	car	NN
cord-006229-7yoilsho	485	6	-	-	HYPH
cord-006229-7yoilsho	485	7	mediated	mediate	VBN
cord-006229-7yoilsho	485	8	Cyp2b10	cyp2b10	NN
cord-006229-7yoilsho	485	9	induction	induction	NN
cord-006229-7yoilsho	485	10	by	by	IN
cord-006229-7yoilsho	485	11	TCPOBOP	TCPOBOP	NNP
cord-006229-7yoilsho	485	12	is	be	VBZ
cord-006229-7yoilsho	485	13	transmitted	transmit	VBN
cord-006229-7yoilsho	485	14	to	to	IN
cord-006229-7yoilsho	485	15	the	the	DT
cord-006229-7yoilsho	485	16	offspring	offspring	NN
cord-006229-7yoilsho	485	17	mainly	mainly	RB
cord-006229-7yoilsho	485	18	via	via	IN
cord-006229-7yoilsho	485	19	lactation	lactation	NN
cord-006229-7yoilsho	485	20	,	,	,
cord-006229-7yoilsho	485	21	resulting	result	VBG
cord-006229-7yoilsho	485	22	in	in	IN
cord-006229-7yoilsho	485	23	lasting	last	VBG
cord-006229-7yoilsho	485	24	phenotypic	phenotypic	JJ
cord-006229-7yoilsho	485	25	consequences	consequence	NNS
cord-006229-7yoilsho	485	26	in	in	IN
cord-006229-7yoilsho	485	27	drug	drug	NN
cord-006229-7yoilsho	485	28	and	and	CC
cord-006229-7yoilsho	485	29	bone	bone	NN
cord-006229-7yoilsho	485	30	metabolism	metabolism	NN
cord-006229-7yoilsho	485	31	.	.	.
cord-006229-7yoilsho	486	1	The	the	DT
cord-006229-7yoilsho	486	2	effects	effect	NNS
cord-006229-7yoilsho	486	3	of	of	IN
cord-006229-7yoilsho	486	4	similarly	similarly	RB
cord-006229-7yoilsho	486	5	lipophilic	lipophilic	JJ
cord-006229-7yoilsho	486	6	drugs	drug	NNS
cord-006229-7yoilsho	486	7	and	and	CC
cord-006229-7yoilsho	486	8	anthropogenic	anthropogenic	JJ
cord-006229-7yoilsho	486	9	environmental	environmental	JJ
cord-006229-7yoilsho	486	10	pollutants	pollutant	NNS
cord-006229-7yoilsho	486	11	are	be	VBP
cord-006229-7yoilsho	486	12	currently	currently	RB
cord-006229-7yoilsho	486	13	being	be	VBG
cord-006229-7yoilsho	486	14	investigated	investigate	VBN
cord-006229-7yoilsho	486	15	.	.	.
cord-006229-7yoilsho	487	1	Such	such	JJ
cord-006229-7yoilsho	487	2	compounds	compound	NNS
cord-006229-7yoilsho	487	3	could	could	MD
cord-006229-7yoilsho	487	4	affect	affect	VB
cord-006229-7yoilsho	487	5	offspring	offspring	NN
cord-006229-7yoilsho	487	6	despite	despite	IN
cord-006229-7yoilsho	487	7	discontinuation	discontinuation	NN
cord-006229-7yoilsho	487	8	of	of	IN
cord-006229-7yoilsho	487	9	intake	intake	NN
cord-006229-7yoilsho	487	10	or	or	CC
cord-006229-7yoilsho	487	11	exposure	exposure	NN
cord-006229-7yoilsho	487	12	well	well	RB
cord-006229-7yoilsho	487	13	ahead	ahead	RB
cord-006229-7yoilsho	487	14	of	of	IN
cord-006229-7yoilsho	487	15	pregnancy	pregnancy	NN
cord-006229-7yoilsho	487	16	.	.	.
cord-006229-7yoilsho	488	1	Age	age	NN
cord-006229-7yoilsho	488	2	-	-	HYPH
cord-006229-7yoilsho	488	3	related	relate	VBN
cord-006229-7yoilsho	488	4	cognitive	cognitive	JJ
cord-006229-7yoilsho	488	5	decline	decline	NN
cord-006229-7yoilsho	488	6	can	can	MD
cord-006229-7yoilsho	488	7	eventually	eventually	RB
cord-006229-7yoilsho	488	8	lead	lead	VB
cord-006229-7yoilsho	488	9	to	to	IN
cord-006229-7yoilsho	488	10	dementia	dementia	NN
cord-006229-7yoilsho	488	11	,	,	,
cord-006229-7yoilsho	488	12	the	the	DT
cord-006229-7yoilsho	488	13	most	most	RBS
cord-006229-7yoilsho	488	14	common	common	JJ
cord-006229-7yoilsho	488	15	mental	mental	JJ
cord-006229-7yoilsho	488	16	illness	illness	NN
cord-006229-7yoilsho	488	17	in	in	IN
cord-006229-7yoilsho	488	18	elderly	elderly	JJ
cord-006229-7yoilsho	488	19	people	people	NNS
cord-006229-7yoilsho	488	20	and	and	CC
cord-006229-7yoilsho	488	21	an	an	DT
cord-006229-7yoilsho	488	22	immense	immense	JJ
cord-006229-7yoilsho	488	23	challenge	challenge	NN
cord-006229-7yoilsho	488	24	for	for	IN
cord-006229-7yoilsho	488	25	patients	patient	NNS
cord-006229-7yoilsho	488	26	,	,	,
cord-006229-7yoilsho	488	27	their	-PRON-	PRP$
cord-006229-7yoilsho	488	28	families	family	NNS
cord-006229-7yoilsho	488	29	and	and	CC
cord-006229-7yoilsho	488	30	caregivers	caregiver	NNS
cord-006229-7yoilsho	488	31	.	.	.
cord-006229-7yoilsho	489	1	Cholinesterase	Cholinesterase	NNP
cord-006229-7yoilsho	489	2	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	489	3	constitute	constitute	VBP
cord-006229-7yoilsho	489	4	the	the	DT
cord-006229-7yoilsho	489	5	most	most	RBS
cord-006229-7yoilsho	489	6	commonly	commonly	RB
cord-006229-7yoilsho	489	7	used	use	VBN
cord-006229-7yoilsho	489	8	antidementia	antidementia	NNP
cord-006229-7yoilsho	489	9	prescription	prescription	NN
cord-006229-7yoilsho	489	10	medication	medication	NN
cord-006229-7yoilsho	489	11	.	.	.
cord-006229-7yoilsho	490	1	The	the	DT
cord-006229-7yoilsho	490	2	standardized	standardized	JJ
cord-006229-7yoilsho	490	3	Ginkgo	Ginkgo	NNP
cord-006229-7yoilsho	490	4	biloba	biloba	NN
cord-006229-7yoilsho	490	5	leaf	leaf	NN
cord-006229-7yoilsho	490	6	extract	extract	NN
cord-006229-7yoilsho	490	7	EGb	EGb	NNP
cord-006229-7yoilsho	490	8	761	761	CD
cord-006229-7yoilsho	490	9	®	®	NN
cord-006229-7yoilsho	490	10	is	be	VBZ
cord-006229-7yoilsho	490	11	approved	approve	VBN
cord-006229-7yoilsho	490	12	for	for	IN
cord-006229-7yoilsho	490	13	treating	treat	VBG
cord-006229-7yoilsho	490	14	age	age	NN
cord-006229-7yoilsho	490	15	-	-	HYPH
cord-006229-7yoilsho	490	16	associated	associate	VBN
cord-006229-7yoilsho	490	17	cognitive	cognitive	JJ
cord-006229-7yoilsho	490	18	impairment	impairment	NN
cord-006229-7yoilsho	490	19	and	and	CC
cord-006229-7yoilsho	490	20	has	have	VBZ
cord-006229-7yoilsho	490	21	been	be	VBN
cord-006229-7yoilsho	490	22	shown	show	VBN
cord-006229-7yoilsho	490	23	to	to	TO
cord-006229-7yoilsho	490	24	improve	improve	VB
cord-006229-7yoilsho	490	25	the	the	DT
cord-006229-7yoilsho	490	26	quality	quality	NN
cord-006229-7yoilsho	490	27	of	of	IN
cord-006229-7yoilsho	490	28	life	life	NN
cord-006229-7yoilsho	490	29	in	in	IN
cord-006229-7yoilsho	490	30	patients	patient	NNS
cord-006229-7yoilsho	490	31	suffering	suffer	VBG
cord-006229-7yoilsho	490	32	from	from	IN
cord-006229-7yoilsho	490	33	mild	mild	JJ
cord-006229-7yoilsho	490	34	dementia	dementia	NN
cord-006229-7yoilsho	490	35	.	.	.
cord-006229-7yoilsho	491	1	A	a	DT
cord-006229-7yoilsho	491	2	clinical	clinical	JJ
cord-006229-7yoilsho	491	3	trial	trial	NN
cord-006229-7yoilsho	491	4	with	with	IN
cord-006229-7yoilsho	491	5	96	96	CD
cord-006229-7yoilsho	491	6	Alzheimer´s	Alzheimer´s	NNP
cord-006229-7yoilsho	491	7	disease	disease	NN
cord-006229-7yoilsho	491	8	patients	patient	NNS
cord-006229-7yoilsho	491	9	indicated	indicate	VBD
cord-006229-7yoilsho	491	10	that	that	IN
cord-006229-7yoilsho	491	11	the	the	DT
cord-006229-7yoilsho	491	12	combined	combine	VBN
cord-006229-7yoilsho	491	13	treatment	treatment	NN
cord-006229-7yoilsho	491	14	with	with	IN
cord-006229-7yoilsho	491	15	donepezil	donepezil	NNP
cord-006229-7yoilsho	491	16	and	and	CC
cord-006229-7yoilsho	491	17	EGb	EGb	NNP
cord-006229-7yoilsho	491	18	761	761	CD
cord-006229-7yoilsho	491	19	®	®	SYM
cord-006229-7yoilsho	491	20	had	have	VBD
cord-006229-7yoilsho	491	21	less	less	JJR
cord-006229-7yoilsho	491	22	side	side	JJ
cord-006229-7yoilsho	491	23	effects	effect	NNS
cord-006229-7yoilsho	491	24	than	than	IN
cord-006229-7yoilsho	491	25	donepezil	donepezil	NNP
cord-006229-7yoilsho	491	26	alone	alone	RB
cord-006229-7yoilsho	492	1	(	(	-LRB-
cord-006229-7yoilsho	492	2	Yancheva	Yancheva	NNP
cord-006229-7yoilsho	492	3	et	et	FW
cord-006229-7yoilsho	492	4	al	al	NNP
cord-006229-7yoilsho	492	5	.	.	NNP
cord-006229-7yoilsho	492	6	,	,	,
cord-006229-7yoilsho	492	7	2009	2009	CD
cord-006229-7yoilsho	492	8	)	)	-RRB-
cord-006229-7yoilsho	492	9	.	.	.
cord-006229-7yoilsho	493	1	In	in	IN
cord-006229-7yoilsho	493	2	an	an	DT
cord-006229-7yoilsho	493	3	animal	animal	NN
cord-006229-7yoilsho	493	4	model	model	NN
cord-006229-7yoilsho	493	5	of	of	IN
cord-006229-7yoilsho	493	6	cognitive	cognitive	JJ
cord-006229-7yoilsho	493	7	aging	aging	NN
cord-006229-7yoilsho	493	8	,	,	,
cord-006229-7yoilsho	493	9	we	-PRON-	PRP
cord-006229-7yoilsho	493	10	compared	compare	VBD
cord-006229-7yoilsho	493	11	the	the	DT
cord-006229-7yoilsho	493	12	effect	effect	NN
cord-006229-7yoilsho	493	13	of	of	IN
cord-006229-7yoilsho	493	14	combined	combine	VBN
cord-006229-7yoilsho	493	15	treatment	treatment	NN
cord-006229-7yoilsho	493	16	with	with	IN
cord-006229-7yoilsho	493	17	EGb	EGb	NNP
cord-006229-7yoilsho	493	18	761	761	CD
cord-006229-7yoilsho	493	19	®	®	NN
cord-006229-7yoilsho	493	20	or	or	CC
cord-006229-7yoilsho	493	21	donepezil	donepezil	NNP
cord-006229-7yoilsho	493	22	monotherapy	monotherapy	NN
cord-006229-7yoilsho	493	23	and	and	CC
cord-006229-7yoilsho	493	24	vehicle	vehicle	NN
cord-006229-7yoilsho	493	25	.	.	.
cord-006229-7yoilsho	494	1	We	-PRON-	PRP
cord-006229-7yoilsho	494	2	compared	compare	VBD
cord-006229-7yoilsho	494	3	the	the	DT
cord-006229-7yoilsho	494	4	effect	effect	NN
cord-006229-7yoilsho	494	5	of	of	IN
cord-006229-7yoilsho	494	6	chronic	chronic	JJ
cord-006229-7yoilsho	494	7	treatment	treatment	NN
cord-006229-7yoilsho	494	8	(	(	-LRB-
cord-006229-7yoilsho	494	9	15	15	CD
cord-006229-7yoilsho	494	10	days	day	NNS
cord-006229-7yoilsho	494	11	of	of	IN
cord-006229-7yoilsho	494	12	pretreatment	pretreatment	NN
cord-006229-7yoilsho	494	13	)	)	-RRB-
cord-006229-7yoilsho	494	14	with	with	IN
cord-006229-7yoilsho	494	15	donepezil	donepezil	NNP
cord-006229-7yoilsho	494	16	(	(	-LRB-
cord-006229-7yoilsho	494	17	1,5	1,5	CD
cord-006229-7yoilsho	494	18	mg	mg	NNP
cord-006229-7yoilsho	494	19	/	/	SYM
cord-006229-7yoilsho	494	20	kg	kg	NNP
cord-006229-7yoilsho	494	21	p.	p.	NN
cord-006229-7yoilsho	494	22	o.	o.	NNP
cord-006229-7yoilsho	494	23	)	)	-RRB-
cord-006229-7yoilsho	494	24	,	,	,
cord-006229-7yoilsho	494	25	EGb	EGb	NNP
cord-006229-7yoilsho	494	26	761	761	CD
cord-006229-7yoilsho	494	27	®	®	NNPS
cord-006229-7yoilsho	494	28	(	(	-LRB-
cord-006229-7yoilsho	494	29	100	100	CD
cord-006229-7yoilsho	494	30	mg	mg	NNP
cord-006229-7yoilsho	494	31	/	/	SYM
cord-006229-7yoilsho	494	32	kg	kg	NNP
cord-006229-7yoilsho	494	33	p.	p.	NN
cord-006229-7yoilsho	494	34	o.	o.	NNP
cord-006229-7yoilsho	494	35	)	)	-RRB-
cord-006229-7yoilsho	494	36	,	,	,
cord-006229-7yoilsho	494	37	or	or	CC
cord-006229-7yoilsho	494	38	the	the	DT
cord-006229-7yoilsho	494	39	combination	combination	NN
cord-006229-7yoilsho	494	40	of	of	IN
cord-006229-7yoilsho	494	41	the	the	DT
cord-006229-7yoilsho	494	42	two	two	CD
cord-006229-7yoilsho	494	43	drugs	drug	NNS
cord-006229-7yoilsho	494	44	,	,	,
cord-006229-7yoilsho	494	45	or	or	CC
cord-006229-7yoilsho	494	46	vehicle	vehicle	NN
cord-006229-7yoilsho	494	47	in	in	IN
cord-006229-7yoilsho	494	48	18	18	CD
cord-006229-7yoilsho	494	49	-20	-20	CD
cord-006229-7yoilsho	494	50	month	month	NN
cord-006229-7yoilsho	494	51	old	old	JJ
cord-006229-7yoilsho	494	52	male	male	JJ
cord-006229-7yoilsho	494	53	OFA	OFA	NNP
cord-006229-7yoilsho	494	54	rats	rat	NNS
cord-006229-7yoilsho	494	55	.	.	.
cord-006229-7yoilsho	495	1	Learning	learning	NN
cord-006229-7yoilsho	495	2	and	and	CC
cord-006229-7yoilsho	495	3	memory	memory	NN
cord-006229-7yoilsho	495	4	performance	performance	NN
cord-006229-7yoilsho	495	5	were	be	VBD
cord-006229-7yoilsho	495	6	assessed	assess	VBN
cord-006229-7yoilsho	495	7	by	by	IN
cord-006229-7yoilsho	495	8	Morris	Morris	NNP
cord-006229-7yoilsho	495	9	water	water	NN
cord-006229-7yoilsho	495	10	maze	maze	NN
cord-006229-7yoilsho	495	11	testing	testing	NN
cord-006229-7yoilsho	495	12	,	,	,
cord-006229-7yoilsho	495	13	motor	motor	NN
cord-006229-7yoilsho	495	14	behavior	behavior	NN
cord-006229-7yoilsho	495	15	in	in	IN
cord-006229-7yoilsho	495	16	an	an	DT
cord-006229-7yoilsho	495	17	open	open	JJ
cord-006229-7yoilsho	495	18	field	field	NN
cord-006229-7yoilsho	495	19	paradigm	paradigm	NN
cord-006229-7yoilsho	495	20	.	.	.
cord-006229-7yoilsho	496	1	In	in	IN
cord-006229-7yoilsho	496	2	addition	addition	NN
cord-006229-7yoilsho	496	3	to	to	IN
cord-006229-7yoilsho	496	4	chronic	chronic	JJ
cord-006229-7yoilsho	496	5	treatment	treatment	NN
cord-006229-7yoilsho	496	6	,	,	,
cord-006229-7yoilsho	496	7	the	the	DT
cord-006229-7yoilsho	496	8	substances	substance	NNS
cord-006229-7yoilsho	496	9	were	be	VBD
cord-006229-7yoilsho	496	10	administered	administer	VBN
cord-006229-7yoilsho	496	11	orally	orally	RB
cord-006229-7yoilsho	496	12	30	30	CD
cord-006229-7yoilsho	496	13	minutes	minute	NNS
cord-006229-7yoilsho	496	14	before	before	IN
cord-006229-7yoilsho	496	15	testing	testing	NN
cord-006229-7yoilsho	496	16	.	.	.
cord-006229-7yoilsho	497	1	Compared	compare	VBN
cord-006229-7yoilsho	497	2	to	to	IN
cord-006229-7yoilsho	497	3	the	the	DT
cord-006229-7yoilsho	497	4	first	first	JJ
cord-006229-7yoilsho	497	5	day	day	NN
cord-006229-7yoilsho	497	6	and	and	CC
cord-006229-7yoilsho	497	7	to	to	IN
cord-006229-7yoilsho	497	8	the	the	DT
cord-006229-7yoilsho	497	9	control	control	NN
cord-006229-7yoilsho	497	10	group	group	NN
cord-006229-7yoilsho	497	11	,	,	,
cord-006229-7yoilsho	497	12	only	only	RB
cord-006229-7yoilsho	497	13	the	the	DT
cord-006229-7yoilsho	497	14	combination	combination	NN
cord-006229-7yoilsho	497	15	group	group	NN
cord-006229-7yoilsho	497	16	showed	show	VBD
cord-006229-7yoilsho	497	17	a	a	DT
cord-006229-7yoilsho	497	18	significant	significant	JJ
cord-006229-7yoilsho	497	19	reduction	reduction	NN
cord-006229-7yoilsho	497	20	in	in	IN
cord-006229-7yoilsho	497	21	latency	latency	NN
cord-006229-7yoilsho	497	22	to	to	TO
cord-006229-7yoilsho	497	23	reach	reach	VB
cord-006229-7yoilsho	497	24	the	the	DT
cord-006229-7yoilsho	497	25	hidden	hidden	JJ
cord-006229-7yoilsho	497	26	platform	platform	NN
cord-006229-7yoilsho	497	27	on	on	IN
cord-006229-7yoilsho	497	28	the	the	DT
cord-006229-7yoilsho	497	29	second	second	JJ
cord-006229-7yoilsho	497	30	day	day	NN
cord-006229-7yoilsho	497	31	of	of	IN
cord-006229-7yoilsho	497	32	testing	testing	NN
cord-006229-7yoilsho	497	33	.	.	.
cord-006229-7yoilsho	498	1	Moreover	moreover	RB
cord-006229-7yoilsho	498	2	,	,	,
cord-006229-7yoilsho	498	3	from	from	IN
cord-006229-7yoilsho	498	4	the	the	DT
cord-006229-7yoilsho	498	5	second	second	JJ
cord-006229-7yoilsho	498	6	day	day	NN
cord-006229-7yoilsho	498	7	of	of	IN
cord-006229-7yoilsho	498	8	testing	testing	NN
cord-006229-7yoilsho	498	9	onwards	onwards	RB
cord-006229-7yoilsho	498	10	,	,	,
cord-006229-7yoilsho	498	11	the	the	DT
cord-006229-7yoilsho	498	12	donepezil	donepezil	NNP
cord-006229-7yoilsho	498	13	,	,	,
cord-006229-7yoilsho	498	14	the	the	DT
cord-006229-7yoilsho	498	15	EGb	EGb	NNP
cord-006229-7yoilsho	498	16	761	761	CD
cord-006229-7yoilsho	498	17	®	®	NNS
cord-006229-7yoilsho	498	18	and	and	CC
cord-006229-7yoilsho	498	19	the	the	DT
cord-006229-7yoilsho	498	20	combination	combination	NN
cord-006229-7yoilsho	498	21	group	group	NN
cord-006229-7yoilsho	498	22	required	require	VBD
cord-006229-7yoilsho	498	23	less	less	JJR
cord-006229-7yoilsho	498	24	time	time	NN
cord-006229-7yoilsho	498	25	to	to	TO
cord-006229-7yoilsho	498	26	reach	reach	VB
cord-006229-7yoilsho	498	27	the	the	DT
cord-006229-7yoilsho	498	28	hidden	hidden	JJ
cord-006229-7yoilsho	498	29	platform	platform	NN
cord-006229-7yoilsho	498	30	compared	compare	VBN
cord-006229-7yoilsho	498	31	to	to	IN
cord-006229-7yoilsho	498	32	the	the	DT
cord-006229-7yoilsho	498	33	first	first	JJ
cord-006229-7yoilsho	498	34	day	day	NN
cord-006229-7yoilsho	498	35	.	.	.
cord-006229-7yoilsho	499	1	The	the	DT
cord-006229-7yoilsho	499	2	control	control	NN
cord-006229-7yoilsho	499	3	group	group	NN
cord-006229-7yoilsho	499	4	did	do	VBD
cord-006229-7yoilsho	499	5	not	not	RB
cord-006229-7yoilsho	499	6	reach	reach	VB
cord-006229-7yoilsho	499	7	the	the	DT
cord-006229-7yoilsho	499	8	same	same	JJ
cord-006229-7yoilsho	499	9	latency	latency	NN
cord-006229-7yoilsho	499	10	reduction	reduction	NN
cord-006229-7yoilsho	499	11	until	until	IN
cord-006229-7yoilsho	499	12	day	day	NN
cord-006229-7yoilsho	499	13	three	three	CD
cord-006229-7yoilsho	499	14	.	.	.
cord-006229-7yoilsho	500	1	There	there	EX
cord-006229-7yoilsho	500	2	were	be	VBD
cord-006229-7yoilsho	500	3	no	no	DT
cord-006229-7yoilsho	500	4	effects	effect	NNS
cord-006229-7yoilsho	500	5	on	on	IN
cord-006229-7yoilsho	500	6	motor	motor	NN
cord-006229-7yoilsho	500	7	behavior	behavior	NN
cord-006229-7yoilsho	500	8	.	.	.
cord-006229-7yoilsho	501	1	These	these	DT
cord-006229-7yoilsho	501	2	results	result	NNS
cord-006229-7yoilsho	501	3	suggest	suggest	VBP
cord-006229-7yoilsho	501	4	a	a	DT
cord-006229-7yoilsho	501	5	superiority	superiority	NN
cord-006229-7yoilsho	501	6	of	of	IN
cord-006229-7yoilsho	501	7	the	the	DT
cord-006229-7yoilsho	501	8	combined	combine	VBN
cord-006229-7yoilsho	501	9	treatment	treatment	NN
cord-006229-7yoilsho	501	10	of	of	IN
cord-006229-7yoilsho	501	11	donepezil	donepezil	NNP
cord-006229-7yoilsho	501	12	with	with	IN
cord-006229-7yoilsho	501	13	EGb	EGb	NNS
cord-006229-7yoilsho	502	1	761	761	CD
cord-006229-7yoilsho	502	2	®	®	.
cord-006229-7yoilsho	503	1	compared	compare	VBN
cord-006229-7yoilsho	503	2	to	to	IN
cord-006229-7yoilsho	503	3	monotherapy	monotherapy	NN
cord-006229-7yoilsho	503	4	.	.	.
cord-006229-7yoilsho	504	1	Literature	literature	NN
cord-006229-7yoilsho	504	2	:	:	:
cord-006229-7yoilsho	504	3	Yancheva	Yancheva	NNP
cord-006229-7yoilsho	504	4	,	,	,
cord-006229-7yoilsho	504	5	S.	S.	NNP
cord-006229-7yoilsho	504	6	,	,	,
cord-006229-7yoilsho	504	7	Ihl	Ihl	NNP
cord-006229-7yoilsho	504	8	,	,	,
cord-006229-7yoilsho	504	9	R.	R.	NNP
cord-006229-7yoilsho	504	10	,	,	,
cord-006229-7yoilsho	504	11	Nikolova	Nikolova	NNP
cord-006229-7yoilsho	504	12	,	,	,
cord-006229-7yoilsho	504	13	G.	G.	NNP
cord-006229-7yoilsho	504	14	,	,	,
cord-006229-7yoilsho	504	15	Panayotov	Panayotov	NNP
cord-006229-7yoilsho	504	16	,	,	,
cord-006229-7yoilsho	504	17	P.	P.	NNP
cord-006229-7yoilsho	504	18	,	,	,
cord-006229-7yoilsho	504	19	Schlaefke	Schlaefke	NNP
cord-006229-7yoilsho	504	20	,	,	,
cord-006229-7yoilsho	504	21	S.	S.	NNP
cord-006229-7yoilsho	504	22	,	,	,
cord-006229-7yoilsho	504	23	&	&	CC
cord-006229-7yoilsho	504	24	Hoerr	Hoerr	NNP
cord-006229-7yoilsho	504	25	,	,	,
cord-006229-7yoilsho	504	26	R.	R.	NNP
cord-006229-7yoilsho	504	27	(	(	-LRB-
cord-006229-7yoilsho	504	28	2009	2009	CD
cord-006229-7yoilsho	504	29	)	)	-RRB-
cord-006229-7yoilsho	504	30	.	.	.
cord-006229-7yoilsho	505	1	Ginkgo	ginkgo	NN
cord-006229-7yoilsho	505	2	biloba	biloba	NN
cord-006229-7yoilsho	505	3	extract	extract	NN
cord-006229-7yoilsho	505	4	EGb	EGb	NNP
cord-006229-7yoilsho	505	5	761(R	761(r	CD
cord-006229-7yoilsho	505	6	)	)	-RRB-
cord-006229-7yoilsho	505	7	,	,	,
cord-006229-7yoilsho	505	8	donepezil	donepezil	NNP
cord-006229-7yoilsho	505	9	or	or	CC
cord-006229-7yoilsho	505	10	both	both	DT
cord-006229-7yoilsho	505	11	combined	combine	VBN
cord-006229-7yoilsho	505	12	in	in	IN
cord-006229-7yoilsho	505	13	the	the	DT
cord-006229-7yoilsho	505	14	treatment	treatment	NN
cord-006229-7yoilsho	505	15	of	of	IN
cord-006229-7yoilsho	505	16	Alzheimer	Alzheimer	NNP
cord-006229-7yoilsho	505	17	's	's	POS
cord-006229-7yoilsho	505	18	disease	disease	NN
cord-006229-7yoilsho	505	19	with	with	IN
cord-006229-7yoilsho	505	20	neuropsychiatric	neuropsychiatric	JJ
cord-006229-7yoilsho	505	21	features	feature	NNS
cord-006229-7yoilsho	505	22	:	:	:
cord-006229-7yoilsho	505	23	a	a	DT
cord-006229-7yoilsho	505	24	randomised	randomised	JJ
cord-006229-7yoilsho	505	25	,	,	,
cord-006229-7yoilsho	505	26	double	double	JJ
cord-006229-7yoilsho	505	27	-	-	HYPH
cord-006229-7yoilsho	505	28	blind	blind	JJ
cord-006229-7yoilsho	505	29	,	,	,
cord-006229-7yoilsho	505	30	exploratory	exploratory	JJ
cord-006229-7yoilsho	505	31	trial	trial	NN
cord-006229-7yoilsho	505	32	.	.	.
cord-006229-7yoilsho	506	1	Aging	age	VBG
cord-006229-7yoilsho	506	2	Ment	Ment	NNP
cord-006229-7yoilsho	506	3	Health	Health	NNP
cord-006229-7yoilsho	506	4	,	,	,
cord-006229-7yoilsho	506	5	13	13	CD
cord-006229-7yoilsho	506	6	(	(	-LRB-
cord-006229-7yoilsho	506	7	2	2	CD
cord-006229-7yoilsho	506	8	)	)	-RRB-
cord-006229-7yoilsho	506	9	,	,	,
cord-006229-7yoilsho	506	10	[	[	-LRB-
cord-006229-7yoilsho	506	11	183	183	CD
cord-006229-7yoilsho	506	12	]	]	-RRB-
cord-006229-7yoilsho	506	13	[	[	-LRB-
cord-006229-7yoilsho	506	14	184	184	CD
cord-006229-7yoilsho	506	15	]	]	-RRB-
cord-006229-7yoilsho	506	16	[	[	-LRB-
cord-006229-7yoilsho	506	17	185	185	CD
cord-006229-7yoilsho	506	18	]	]	-RRB-
cord-006229-7yoilsho	506	19	[	[	-LRB-
cord-006229-7yoilsho	506	20	186	186	CD
cord-006229-7yoilsho	506	21	]	]	-RRB-
cord-006229-7yoilsho	506	22	[	[	-LRB-
cord-006229-7yoilsho	506	23	187	187	CD
cord-006229-7yoilsho	506	24	]	]	-RRB-
cord-006229-7yoilsho	506	25	[	[	-LRB-
cord-006229-7yoilsho	506	26	188	188	CD
cord-006229-7yoilsho	506	27	]	]	-RRB-
cord-006229-7yoilsho	506	28	[	[	-LRB-
cord-006229-7yoilsho	506	29	189	189	CD
cord-006229-7yoilsho	506	30	]	]	-RRB-
cord-006229-7yoilsho	506	31	[	[	-LRB-
cord-006229-7yoilsho	506	32	190	190	CD
cord-006229-7yoilsho	506	33	]	]	-RRB-
cord-006229-7yoilsho	506	34	Institut	Institut	NNP
cord-006229-7yoilsho	506	35	für	für	IN
cord-006229-7yoilsho	506	36	Vegetative	Vegetative	NNP
cord-006229-7yoilsho	506	37	Physiologie	Physiologie	NNP
cord-006229-7yoilsho	506	38	und	und	IN
cord-006229-7yoilsho	506	39	Pathophysiologie	Pathophysiologie	NNP
cord-006229-7yoilsho	506	40	,	,	,
cord-006229-7yoilsho	506	41	Göttingen	Göttingen	NNP
cord-006229-7yoilsho	506	42	,	,	,
cord-006229-7yoilsho	506	43	Germany	Germany	NNP
cord-006229-7yoilsho	506	44	values	value	NNS
cord-006229-7yoilsho	506	45	are	be	VBP
cord-006229-7yoilsho	506	46	well	well	RB
cord-006229-7yoilsho	506	47	below	below	IN
cord-006229-7yoilsho	506	48	the	the	DT
cord-006229-7yoilsho	506	49	plasma	plasma	NN
cord-006229-7yoilsho	506	50	concentrations	concentration	NNS
cord-006229-7yoilsho	506	51	(	(	-LRB-
cord-006229-7yoilsho	507	1	3	3	LS
cord-006229-7yoilsho	507	2	-	-	SYM
cord-006229-7yoilsho	507	3	28	28	CD
cord-006229-7yoilsho	507	4	µM	µm	NN
cord-006229-7yoilsho	507	5	;	;	:
cord-006229-7yoilsho	507	6	Just	just	RB
cord-006229-7yoilsho	507	7	et	et	FW
cord-006229-7yoilsho	507	8	al	al	NNP
cord-006229-7yoilsho	507	9	.	.	.
cord-006229-7yoilsho	508	1	Expert	Expert	NNP
cord-006229-7yoilsho	508	2	Opin	Opin	NNP
cord-006229-7yoilsho	508	3	Emerging	Emerging	NNP
cord-006229-7yoilsho	508	4	Drugs	drug	NNS
cord-006229-7yoilsho	508	5	20	20	CD
cord-006229-7yoilsho	508	6	:	:	:
cord-006229-7yoilsho	508	7	161	161	CD
cord-006229-7yoilsho	508	8	-	-	SYM
cord-006229-7yoilsho	508	9	164	164	CD
cord-006229-7yoilsho	508	10	,	,	,
cord-006229-7yoilsho	508	11	2015	2015	CD
cord-006229-7yoilsho	508	12	)	)	-RRB-
cord-006229-7yoilsho	508	13	observed	observe	VBN
cord-006229-7yoilsho	508	14	in	in	IN
cord-006229-7yoilsho	508	15	patients	patient	NNS
cord-006229-7yoilsho	508	16	treated	treat	VBN
cord-006229-7yoilsho	508	17	with	with	IN
cord-006229-7yoilsho	508	18	dantrolene	dantrolene	NN
cord-006229-7yoilsho	508	19	.	.	.
cord-006229-7yoilsho	509	1	Although	although	IN
cord-006229-7yoilsho	509	2	not	not	RB
cord-006229-7yoilsho	509	3	yet	yet	RB
cord-006229-7yoilsho	509	4	proven	prove	VBN
cord-006229-7yoilsho	509	5	directly	directly	RB
cord-006229-7yoilsho	509	6	,	,	,
cord-006229-7yoilsho	509	7	OAT3	OAT3	NNP
cord-006229-7yoilsho	509	8	may	may	MD
cord-006229-7yoilsho	509	9	be	be	VB
cord-006229-7yoilsho	509	10	involved	involve	VBN
cord-006229-7yoilsho	509	11	in	in	IN
cord-006229-7yoilsho	509	12	renal	renal	JJ
cord-006229-7yoilsho	509	13	secretion	secretion	NN
cord-006229-7yoilsho	509	14	of	of	IN
cord-006229-7yoilsho	509	15	dantrolene	dantrolene	NN
cord-006229-7yoilsho	509	16	and	and	CC
cord-006229-7yoilsho	509	17	5-OH	5-oh	CD
cord-006229-7yoilsho	509	18	dantrolene	dantrolene	NN
cord-006229-7yoilsho	509	19	by	by	IN
cord-006229-7yoilsho	509	20	mediating	mediate	VBG
cord-006229-7yoilsho	509	21	the	the	DT
cord-006229-7yoilsho	509	22	first	first	JJ
cord-006229-7yoilsho	509	23	step	step	NN
cord-006229-7yoilsho	509	24	,	,	,
cord-006229-7yoilsho	509	25	i.e.	i.e.	FW
cord-006229-7yoilsho	509	26	the	the	DT
cord-006229-7yoilsho	509	27	uptake	uptake	NN
cord-006229-7yoilsho	509	28	across	across	IN
cord-006229-7yoilsho	509	29	the	the	DT
cord-006229-7yoilsho	509	30	basolateral	basolateral	JJ
cord-006229-7yoilsho	509	31	membrane	membrane	NN
cord-006229-7yoilsho	509	32	of	of	IN
cord-006229-7yoilsho	509	33	proximal	proximal	JJ
cord-006229-7yoilsho	509	34	tubule	tubule	NN
cord-006229-7yoilsho	509	35	cells	cell	NNS
cord-006229-7yoilsho	509	36	.	.	.
cord-006229-7yoilsho	510	1	The	the	DT
cord-006229-7yoilsho	510	2	second	second	JJ
cord-006229-7yoilsho	510	3	step	step	NN
cord-006229-7yoilsho	510	4	,	,	,
cord-006229-7yoilsho	510	5	the	the	DT
cord-006229-7yoilsho	510	6	release	release	NN
cord-006229-7yoilsho	510	7	of	of	IN
cord-006229-7yoilsho	510	8	these	these	DT
cord-006229-7yoilsho	510	9	compounds	compound	NNS
cord-006229-7yoilsho	510	10	into	into	IN
cord-006229-7yoilsho	510	11	the	the	DT
cord-006229-7yoilsho	510	12	urine	urine	NN
cord-006229-7yoilsho	510	13	across	across	IN
cord-006229-7yoilsho	510	14	the	the	DT
cord-006229-7yoilsho	510	15	luminal	luminal	JJ
cord-006229-7yoilsho	510	16	membrane	membrane	NN
cord-006229-7yoilsho	510	17	,	,	,
cord-006229-7yoilsho	510	18	is	be	VBZ
cord-006229-7yoilsho	510	19	possibly	possibly	RB
cord-006229-7yoilsho	510	20	mediated	mediate	VBN
cord-006229-7yoilsho	510	21	by	by	IN
cord-006229-7yoilsho	510	22	MRP4	MRP4	NNP
cord-006229-7yoilsho	510	23	.	.	.
cord-006229-7yoilsho	511	1	Since	since	IN
cord-006229-7yoilsho	511	2	OAT3	OAT3	NNP
cord-006229-7yoilsho	511	3	was	be	VBD
cord-006229-7yoilsho	511	4	also	also	RB
cord-006229-7yoilsho	511	5	detected	detect	VBN
cord-006229-7yoilsho	511	6	in	in	IN
cord-006229-7yoilsho	511	7	the	the	DT
cord-006229-7yoilsho	511	8	cytoplasmic	cytoplasmic	JJ
cord-006229-7yoilsho	511	9	membrane	membrane	NN
cord-006229-7yoilsho	511	10	of	of	IN
cord-006229-7yoilsho	511	11	skeletal	skeletal	JJ
cord-006229-7yoilsho	511	12	muscle	muscle	NN
cord-006229-7yoilsho	511	13	cells	cell	NNS
cord-006229-7yoilsho	511	14	(	(	-LRB-
cord-006229-7yoilsho	511	15	Takeda	Takeda	NNP
cord-006229-7yoilsho	511	16	et	et	NNP
cord-006229-7yoilsho	511	17	al	al	NNP
cord-006229-7yoilsho	511	18	.	.	.
cord-006229-7yoilsho	512	1	Europ	Europ	NNP
cord-006229-7yoilsho	512	2	.	.	.
cord-006229-7yoilsho	512	3	J.	J.	NNP
cord-006229-7yoilsho	512	4	Pharmacol	Pharmacol	NNP
cord-006229-7yoilsho	512	5	.	.	.
cord-006229-7yoilsho	513	1	483	483	CD
cord-006229-7yoilsho	513	2	:	:	SYM
cord-006229-7yoilsho	513	3	133	133	CD
cord-006229-7yoilsho	513	4	-	-	SYM
cord-006229-7yoilsho	513	5	138	138	CD
cord-006229-7yoilsho	513	6	,	,	,
cord-006229-7yoilsho	513	7	2004	2004	CD
cord-006229-7yoilsho	513	8	)	)	-RRB-
cord-006229-7yoilsho	513	9	,	,	,
cord-006229-7yoilsho	513	10	dantrolene	dantrolene	NNP
cord-006229-7yoilsho	513	11	may	may	MD
cord-006229-7yoilsho	513	12	reach	reach	VB
cord-006229-7yoilsho	513	13	its	-PRON-	PRP$
cord-006229-7yoilsho	513	14	target	target	NN
cord-006229-7yoilsho	513	15	,	,	,
cord-006229-7yoilsho	513	16	the	the	DT
cord-006229-7yoilsho	513	17	intracellular	intracellular	JJ
cord-006229-7yoilsho	513	18	ryanodine	ryanodine	JJ
cord-006229-7yoilsho	513	19	receptor	receptor	NN
cord-006229-7yoilsho	513	20	,	,	,
cord-006229-7yoilsho	513	21	RyR1	RyR1	''
cord-006229-7yoilsho	513	22	,	,	,
cord-006229-7yoilsho	513	23	by	by	IN
cord-006229-7yoilsho	513	24	influx	influx	NN
cord-006229-7yoilsho	513	25	through	through	IN
cord-006229-7yoilsho	513	26	OAT3	OAT3	NNP
cord-006229-7yoilsho	513	27	,	,	,
cord-006229-7yoilsho	513	28	where	where	WRB
cord-006229-7yoilsho	513	29	it	-PRON-	PRP
cord-006229-7yoilsho	513	30	inhibits	inhibit	VBZ
cord-006229-7yoilsho	513	31	calcium	calcium	NN
cord-006229-7yoilsho	513	32	efflux	efflux	NN
cord-006229-7yoilsho	513	33	by	by	IN
cord-006229-7yoilsho	513	34	RyR1	RyR1	NNPS
cord-006229-7yoilsho	513	35	thereby	thereby	RB
cord-006229-7yoilsho	513	36	preventing	prevent	VBG
cord-006229-7yoilsho	513	37	severe	severe	JJ
cord-006229-7yoilsho	513	38	muscle	muscle	NN
cord-006229-7yoilsho	513	39	contraction	contraction	NN
cord-006229-7yoilsho	513	40	and	and	CC
cord-006229-7yoilsho	513	41	malignant	malignant	JJ
cord-006229-7yoilsho	513	42	hyperthermia	hyperthermia	NN
cord-006229-7yoilsho	513	43	.	.	.
cord-006229-7yoilsho	514	1	This	this	DT
cord-006229-7yoilsho	514	2	assumption	assumption	NN
cord-006229-7yoilsho	514	3	,	,	,
cord-006229-7yoilsho	514	4	however	however	RB
cord-006229-7yoilsho	514	5	,	,	,
cord-006229-7yoilsho	514	6	awaits	await	VBZ
cord-006229-7yoilsho	514	7	a	a	DT
cord-006229-7yoilsho	514	8	direct	direct	JJ
cord-006229-7yoilsho	514	9	demonstration	demonstration	NN
cord-006229-7yoilsho	514	10	of	of	IN
cord-006229-7yoilsho	514	11	dantrolene	dantrolene	JJ
cord-006229-7yoilsho	514	12	transport	transport	NN
cord-006229-7yoilsho	514	13	by	by	IN
cord-006229-7yoilsho	514	14	OAT3	OAT3	NNP
cord-006229-7yoilsho	514	15	.	.	.
cord-006229-7yoilsho	515	1	In	in	IN
cord-006229-7yoilsho	515	2	addition	addition	NN
cord-006229-7yoilsho	515	3	,	,	,
cord-006229-7yoilsho	515	4	we	-PRON-	PRP
cord-006229-7yoilsho	515	5	identified	identify	VBD
cord-006229-7yoilsho	515	6	,	,	,
cord-006229-7yoilsho	515	7	besides	besides	IN
cord-006229-7yoilsho	515	8	dantrolene	dantrolene	NN
cord-006229-7yoilsho	515	9	and	and	CC
cord-006229-7yoilsho	515	10	5-OH	5-oh	CD
cord-006229-7yoilsho	515	11	dantrolene	dantrolene	NN
cord-006229-7yoilsho	515	12	,	,	,
cord-006229-7yoilsho	515	13	several	several	JJ
cord-006229-7yoilsho	515	14	further	further	JJ
cord-006229-7yoilsho	515	15	FDAapproved	fdaapproved	JJ
cord-006229-7yoilsho	515	16	drugs	drug	NNS
cord-006229-7yoilsho	515	17	such	such	JJ
cord-006229-7yoilsho	515	18	as	as	IN
cord-006229-7yoilsho	515	19	tyrphostin	tyrphostin	NNP
cord-006229-7yoilsho	515	20	AG	AG	NNP
cord-006229-7yoilsho	515	21	1478	1478	CD
cord-006229-7yoilsho	515	22	,	,	,
cord-006229-7yoilsho	515	23	ceefourin	ceefourin	NNP
cord-006229-7yoilsho	515	24	1	1	CD
cord-006229-7yoilsho	515	25	,	,	,
cord-006229-7yoilsho	515	26	glafenine	glafenine	NNP
cord-006229-7yoilsho	515	27	,	,	,
cord-006229-7yoilsho	515	28	nalidixic	nalidixic	RB
cord-006229-7yoilsho	515	29	acid	acid	NN
cord-006229-7yoilsho	515	30	,	,	,
cord-006229-7yoilsho	515	31	and	and	CC
cord-006229-7yoilsho	515	32	prazosine	prazosine	NN
cord-006229-7yoilsho	515	33	,	,	,
cord-006229-7yoilsho	515	34	as	as	IN
cord-006229-7yoilsho	515	35	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	515	36	of	of	IN
cord-006229-7yoilsho	515	37	ES	ES	NNP
cord-006229-7yoilsho	515	38	uptake	uptake	NN
cord-006229-7yoilsho	515	39	by	by	IN
cord-006229-7yoilsho	515	40	OAT3	OAT3	NNP
cord-006229-7yoilsho	515	41	.	.	.
cord-006229-7yoilsho	516	1	controls	control	VBZ
cord-006229-7yoilsho	516	2	1	1	CD
cord-006229-7yoilsho	516	3	with	with	IN
cord-006229-7yoilsho	516	4	other	other	JJ
cord-006229-7yoilsho	516	5	defects	defect	NNS
cord-006229-7yoilsho	516	6	and	and	CC
cord-006229-7yoilsho	516	7	controls	control	VBZ
cord-006229-7yoilsho	516	8	2	2	CD
cord-006229-7yoilsho	516	9	with	with	IN
cord-006229-7yoilsho	516	10	genetic	genetic	JJ
cord-006229-7yoilsho	516	11	disorders	disorder	NNS
cord-006229-7yoilsho	516	12	.	.	.
cord-006229-7yoilsho	517	1	All	all	DT
cord-006229-7yoilsho	517	2	drugs	drug	NNS
cord-006229-7yoilsho	517	3	used	use	VBN
cord-006229-7yoilsho	517	4	in	in	IN
cord-006229-7yoilsho	517	5	the	the	DT
cord-006229-7yoilsho	517	6	first	first	JJ
cord-006229-7yoilsho	517	7	trimester	trimester	NN
cord-006229-7yoilsho	517	8	were	be	VBD
cord-006229-7yoilsho	517	9	identified	identify	VBN
cord-006229-7yoilsho	517	10	from	from	IN
cord-006229-7yoilsho	517	11	the	the	DT
cord-006229-7yoilsho	517	12	database	database	NN
cord-006229-7yoilsho	517	13	,	,	,
cord-006229-7yoilsho	517	14	and	and	CC
cord-006229-7yoilsho	517	15	were	be	VBD
cord-006229-7yoilsho	517	16	cross	cross	NN
cord-006229-7yoilsho	517	17	-	-	VBN
cord-006229-7yoilsho	517	18	referenced	reference	VBN
cord-006229-7yoilsho	517	19	against	against	IN
cord-006229-7yoilsho	517	20	previously	previously	RB
cord-006229-7yoilsho	517	21	compiled	compile	VBN
cord-006229-7yoilsho	517	22	lists	list	NNS
cord-006229-7yoilsho	517	23	of	of	IN
cord-006229-7yoilsho	517	24	drugs	drug	NNS
cord-006229-7yoilsho	517	25	with	with	IN
cord-006229-7yoilsho	517	26	reactive	reactive	JJ
cord-006229-7yoilsho	517	27	intermediates	intermediate	NNS
cord-006229-7yoilsho	517	28	and	and	CC
cord-006229-7yoilsho	517	29	drugs	drug	NNS
cord-006229-7yoilsho	517	30	with	with	IN
cord-006229-7yoilsho	517	31	FAA	FAA	NNP
cord-006229-7yoilsho	517	32	.	.	.
cord-006229-7yoilsho	518	1	Drugs	drug	NNS
cord-006229-7yoilsho	518	2	with	with	IN
cord-006229-7yoilsho	518	3	reactive	reactive	JJ
cord-006229-7yoilsho	518	4	intermediates	intermediate	NNS
cord-006229-7yoilsho	518	5	,	,	,
cord-006229-7yoilsho	518	6	with	with	IN
cord-006229-7yoilsho	518	7	systemic	systemic	JJ
cord-006229-7yoilsho	518	8	absorption	absorption	NN
cord-006229-7yoilsho	518	9	and	and	CC
cord-006229-7yoilsho	518	10	with	with	IN
cord-006229-7yoilsho	518	11	a	a	DT
cord-006229-7yoilsho	518	12	daily	daily	JJ
cord-006229-7yoilsho	518	13	dose	dose	NN
cord-006229-7yoilsho	519	1	≥50	≥50	NNP
cord-006229-7yoilsho	520	1	mg	mg	PRP
cord-006229-7yoilsho	520	2	were	be	VBD
cord-006229-7yoilsho	520	3	considered	consider	VBN
cord-006229-7yoilsho	520	4	OS	os	NN
cord-006229-7yoilsho	520	5	-	-	HYPH
cord-006229-7yoilsho	520	6	inducing	induce	VBG
cord-006229-7yoilsho	520	7	drugs	drug	NNS
cord-006229-7yoilsho	520	8	.	.	.
cord-006229-7yoilsho	521	1	When	when	WRB
cord-006229-7yoilsho	521	2	there	there	EX
cord-006229-7yoilsho	521	3	was	be	VBD
cord-006229-7yoilsho	521	4	an	an	DT
cord-006229-7yoilsho	521	5	association	association	NN
cord-006229-7yoilsho	521	6	between	between	IN
cord-006229-7yoilsho	521	7	OS	OS	NNP
cord-006229-7yoilsho	521	8	-	-	HYPH
cord-006229-7yoilsho	521	9	inducing	induce	VBG
cord-006229-7yoilsho	521	10	drugs	drug	NNS
cord-006229-7yoilsho	521	11	and	and	CC
cord-006229-7yoilsho	521	12	a	a	DT
cord-006229-7yoilsho	521	13	group	group	NN
cord-006229-7yoilsho	521	14	of	of	IN
cord-006229-7yoilsho	521	15	birth	birth	NN
cord-006229-7yoilsho	521	16	defects	defect	NNS
cord-006229-7yoilsho	521	17	,	,	,
cord-006229-7yoilsho	521	18	we	-PRON-	PRP
cord-006229-7yoilsho	521	19	further	further	RB
cord-006229-7yoilsho	521	20	investigated	investigate	VBD
cord-006229-7yoilsho	521	21	two	two	CD
cord-006229-7yoilsho	521	22	different	different	JJ
cord-006229-7yoilsho	521	23	FAA	FAA	NNP
cord-006229-7yoilsho	521	24	exposure	exposure	NN
cord-006229-7yoilsho	521	25	categories	category	NNS
cord-006229-7yoilsho	521	26	:	:	:
cord-006229-7yoilsho	521	27	concurrent	concurrent	JJ
cord-006229-7yoilsho	521	28	exposure	exposure	NN
cord-006229-7yoilsho	521	29	to	to	IN
cord-006229-7yoilsho	521	30	both	both	CC
cord-006229-7yoilsho	521	31	OS	os	NN
cord-006229-7yoilsho	521	32	-	-	HYPH
cord-006229-7yoilsho	521	33	inducing	induce	VBG
cord-006229-7yoilsho	521	34	drugs	drug	NNS
cord-006229-7yoilsho	521	35	and	and	CC
cord-006229-7yoilsho	521	36	FAA	FAA	NNP
cord-006229-7yoilsho	521	37	drugs	drug	NNS
cord-006229-7yoilsho	521	38	(	(	-LRB-
cord-006229-7yoilsho	521	39	OS+/FAA+	OS+/FAA+	NNP
cord-006229-7yoilsho	521	40	)	)	-RRB-
cord-006229-7yoilsho	521	41	and	and	CC
cord-006229-7yoilsho	521	42	exposure	exposure	NN
cord-006229-7yoilsho	521	43	to	to	IN
cord-006229-7yoilsho	521	44	OS	os	NN
cord-006229-7yoilsho	521	45	-	-	HYPH
cord-006229-7yoilsho	521	46	inducing	induce	VBG
cord-006229-7yoilsho	521	47	drugs	drug	NNS
cord-006229-7yoilsho	521	48	only	only	RB
cord-006229-7yoilsho	521	49	(	(	-LRB-
cord-006229-7yoilsho	521	50	OS+/FAA-	OS+/FAA-	NNP
cord-006229-7yoilsho	521	51	)	)	-RRB-
cord-006229-7yoilsho	521	52	.	.	.
cord-006229-7yoilsho	522	1	When	when	WRB
cord-006229-7yoilsho	522	2	the	the	DT
cord-006229-7yoilsho	522	3	number	number	NN
cord-006229-7yoilsho	522	4	of	of	IN
cord-006229-7yoilsho	522	5	subjects	subject	NNS
cord-006229-7yoilsho	522	6	allowed	allow	VBN
cord-006229-7yoilsho	522	7	(	(	-LRB-
cord-006229-7yoilsho	522	8	at	at	RB
cord-006229-7yoilsho	522	9	least	least	RBS
cord-006229-7yoilsho	522	10	five	five	CD
cord-006229-7yoilsho	522	11	cases	case	NNS
cord-006229-7yoilsho	522	12	/	/	SYM
cord-006229-7yoilsho	522	13	controls	control	NNS
cord-006229-7yoilsho	522	14	were	be	VBD
cord-006229-7yoilsho	522	15	exposed	expose	VBN
cord-006229-7yoilsho	522	16	)	)	-RRB-
cord-006229-7yoilsho	522	17	,	,	,
cord-006229-7yoilsho	522	18	we	-PRON-	PRP
cord-006229-7yoilsho	522	19	examined	examine	VBD
cord-006229-7yoilsho	522	20	the	the	DT
cord-006229-7yoilsho	522	21	role	role	NN
cord-006229-7yoilsho	522	22	of	of	IN
cord-006229-7yoilsho	522	23	FOLIC	folic	NN
cord-006229-7yoilsho	522	24	.	.	.
cord-006229-7yoilsho	523	1	Odds	odd	NNS
cord-006229-7yoilsho	523	2	ratios	ratio	NNS
cord-006229-7yoilsho	523	3	(	(	-LRB-
cord-006229-7yoilsho	523	4	ORs	or	NNS
cord-006229-7yoilsho	523	5	)	)	-RRB-
cord-006229-7yoilsho	523	6	with	with	IN
cord-006229-7yoilsho	523	7	95	95	CD
cord-006229-7yoilsho	523	8	%	%	NN
cord-006229-7yoilsho	523	9	confidence	confidence	NN
cord-006229-7yoilsho	523	10	intervals	interval	NNS
cord-006229-7yoilsho	523	11	were	be	VBD
cord-006229-7yoilsho	523	12	adjusted	adjust	VBN
cord-006229-7yoilsho	523	13	for	for	IN
cord-006229-7yoilsho	523	14	maternal	maternal	JJ
cord-006229-7yoilsho	523	15	smoking	smoking	NN
cord-006229-7yoilsho	523	16	and	and	CC
cord-006229-7yoilsho	523	17	alcohol	alcohol	NN
cord-006229-7yoilsho	523	18	use	use	NN
cord-006229-7yoilsho	523	19	in	in	IN
cord-006229-7yoilsho	523	20	the	the	DT
cord-006229-7yoilsho	523	21	first	first	JJ
cord-006229-7yoilsho	523	22	trimester	trimester	NN
cord-006229-7yoilsho	523	23	in	in	IN
cord-006229-7yoilsho	523	24	controls	control	NNS
cord-006229-7yoilsho	523	25	1	1	CD
cord-006229-7yoilsho	523	26	and	and	CC
cord-006229-7yoilsho	523	27	additionally	additionally	RB
cord-006229-7yoilsho	523	28	adjusted	adjust	VBN
cord-006229-7yoilsho	523	29	for	for	IN
cord-006229-7yoilsho	523	30	maternal	maternal	JJ
cord-006229-7yoilsho	523	31	age	age	NN
cord-006229-7yoilsho	523	32	in	in	IN
cord-006229-7yoilsho	523	33	controls	control	NNS
cord-006229-7yoilsho	523	34	2	2	CD
cord-006229-7yoilsho	523	35	.	.	.
cord-006229-7yoilsho	524	1	Results	result	NNS
cord-006229-7yoilsho	524	2	:	:	:
cord-006229-7yoilsho	525	1	A	a	DT
cord-006229-7yoilsho	525	2	total	total	NN
cord-006229-7yoilsho	525	3	of	of	IN
cord-006229-7yoilsho	525	4	nine	nine	CD
cord-006229-7yoilsho	525	5	groups	group	NNS
cord-006229-7yoilsho	525	6	of	of	IN
cord-006229-7yoilsho	525	7	birth	birth	NN
cord-006229-7yoilsho	525	8	defects	defect	NNS
cord-006229-7yoilsho	525	9	were	be	VBD
cord-006229-7yoilsho	525	10	investigated	investigate	VBN
cord-006229-7yoilsho	525	11	.	.	.
cord-006229-7yoilsho	526	1	Only	only	RB
cord-006229-7yoilsho	526	2	nervous	nervous	JJ
cord-006229-7yoilsho	526	3	system	system	NN
cord-006229-7yoilsho	526	4	defects	defect	NNS
cord-006229-7yoilsho	526	5	were	be	VBD
cord-006229-7yoilsho	526	6	associated	associate	VBN
cord-006229-7yoilsho	526	7	with	with	IN
cord-006229-7yoilsho	526	8	OS	os	NN
cord-006229-7yoilsho	526	9	-	-	HYPH
cord-006229-7yoilsho	526	10	inducing	induce	VBG
cord-006229-7yoilsho	526	11	drugs	drug	NNS
cord-006229-7yoilsho	526	12	.	.	.
cord-006229-7yoilsho	527	1	Exposure	exposure	NN
cord-006229-7yoilsho	527	2	rates	rate	NNS
cord-006229-7yoilsho	527	3	were	be	VBD
cord-006229-7yoilsho	527	4	65/464	65/464	CD
cord-006229-7yoilsho	527	5	(	(	-LRB-
cord-006229-7yoilsho	527	6	14.0	14.0	CD
cord-006229-7yoilsho	527	7	%	%	NN
cord-006229-7yoilsho	527	8	)	)	-RRB-
cord-006229-7yoilsho	527	9	for	for	IN
cord-006229-7yoilsho	527	10	cases	case	NNS
cord-006229-7yoilsho	527	11	,	,	,
cord-006229-7yoilsho	527	12	512/6033	512/6033	CD
cord-006229-7yoilsho	527	13	(	(	-LRB-
cord-006229-7yoilsho	527	14	8.5	8.5	CD
cord-006229-7yoilsho	527	15	%	%	NN
cord-006229-7yoilsho	527	16	)	)	-RRB-
cord-006229-7yoilsho	527	17	for	for	IN
cord-006229-7yoilsho	527	18	controls	control	NNS
cord-006229-7yoilsho	527	19	1	1	CD
cord-006229-7yoilsho	527	20	and	and	CC
cord-006229-7yoilsho	527	21	130/1564	130/1564	NNP
cord-006229-7yoilsho	527	22	(	(	-LRB-
cord-006229-7yoilsho	527	23	8.3	8.3	CD
cord-006229-7yoilsho	527	24	%	%	NN
cord-006229-7yoilsho	527	25	)	)	-RRB-
cord-006229-7yoilsho	527	26	for	for	IN
cord-006229-7yoilsho	527	27	controls	control	NNS
cord-006229-7yoilsho	527	28	2	2	CD
cord-006229-7yoilsho	527	29	and	and	CC
cord-006229-7yoilsho	527	30	adjusted	adjust	VBN
cord-006229-7yoilsho	527	31	ORs	or	NNS
cord-006229-7yoilsho	527	32	(	(	-LRB-
cord-006229-7yoilsho	527	33	95%CIs	95%cis	CD
cord-006229-7yoilsho	527	34	)	)	-RRB-
cord-006229-7yoilsho	527	35	were	be	VBD
cord-006229-7yoilsho	527	36	1.71	1.71	CD
cord-006229-7yoilsho	527	37	(	(	-LRB-
cord-006229-7yoilsho	527	38	1.29	1.29	CD
cord-006229-7yoilsho	527	39	-	-	SYM
cord-006229-7yoilsho	527	40	2.26	2.26	CD
cord-006229-7yoilsho	527	41	)	)	-RRB-
cord-006229-7yoilsho	527	42	and	and	CC
cord-006229-7yoilsho	527	43	1.77	1.77	CD
cord-006229-7yoilsho	527	44	(	(	-LRB-
cord-006229-7yoilsho	527	45	1.27	1.27	CD
cord-006229-7yoilsho	527	46	-	-	SYM
cord-006229-7yoilsho	527	47	2.46	2.46	CD
cord-006229-7yoilsho	527	48	)	)	-RRB-
cord-006229-7yoilsho	527	49	,	,	,
cord-006229-7yoilsho	527	50	respectively	respectively	RB
cord-006229-7yoilsho	527	51	.	.	.
cord-006229-7yoilsho	528	1	This	this	DT
cord-006229-7yoilsho	528	2	association	association	NN
cord-006229-7yoilsho	528	3	was	be	VBD
cord-006229-7yoilsho	528	4	unchanged	unchanged	JJ
cord-006229-7yoilsho	528	5	when	when	WRB
cord-006229-7yoilsho	528	6	we	-PRON-	PRP
cord-006229-7yoilsho	528	7	examined	examine	VBD
cord-006229-7yoilsho	528	8	OS+/FAA+	OS+/FAA+	NNP
cord-006229-7yoilsho	528	9	and	and	CC
cord-006229-7yoilsho	528	10	OS+/FAA	os+/faa	RB
cord-006229-7yoilsho	528	11	-	-	HYPH
cord-006229-7yoilsho	528	12	separately	separately	RB
cord-006229-7yoilsho	528	13	.	.	.
cord-006229-7yoilsho	529	1	The	the	DT
cord-006229-7yoilsho	529	2	OS+/FAA+	OS+/FAA+	NNP
cord-006229-7yoilsho	529	3	category	category	NN
cord-006229-7yoilsho	529	4	,	,	,
cord-006229-7yoilsho	529	5	however	however	RB
cord-006229-7yoilsho	529	6	,	,	,
cord-006229-7yoilsho	529	7	had	have	VBD
cord-006229-7yoilsho	529	8	slightly	slightly	RB
cord-006229-7yoilsho	529	9	higher	high	JJR
cord-006229-7yoilsho	529	10	OR	or	JJ
cord-006229-7yoilsho	529	11	values	value	NNS
cord-006229-7yoilsho	529	12	than	than	IN
cord-006229-7yoilsho	529	13	the	the	DT
cord-006229-7yoilsho	529	14	OS+/FAA-(2.41	OS+/FAA-(2.41	NNP
cord-006229-7yoilsho	529	15	vs.	vs.	CC
cord-006229-7yoilsho	529	16	1.61	1.61	CD
cord-006229-7yoilsho	529	17	for	for	IN
cord-006229-7yoilsho	529	18	controls	control	NNS
cord-006229-7yoilsho	529	19	1	1	CD
cord-006229-7yoilsho	529	20	,	,	,
cord-006229-7yoilsho	529	21	and	and	CC
cord-006229-7yoilsho	529	22	2.55	2.55	CD
cord-006229-7yoilsho	529	23	vs.	vs.	IN
cord-006229-7yoilsho	529	24	1.67	1.67	CD
cord-006229-7yoilsho	529	25	for	for	IN
cord-006229-7yoilsho	529	26	controls	control	NNS
cord-006229-7yoilsho	529	27	2	2	CD
cord-006229-7yoilsho	529	28	)	)	-RRB-
cord-006229-7yoilsho	529	29	.	.	.
cord-006229-7yoilsho	530	1	Because	because	IN
cord-006229-7yoilsho	530	2	of	of	IN
cord-006229-7yoilsho	530	3	the	the	DT
cord-006229-7yoilsho	530	4	low	low	JJ
cord-006229-7yoilsho	530	5	number	number	NN
cord-006229-7yoilsho	530	6	of	of	IN
cord-006229-7yoilsho	530	7	exposed	expose	VBN
cord-006229-7yoilsho	530	8	subjects	subject	NNS
cord-006229-7yoilsho	530	9	,	,	,
cord-006229-7yoilsho	530	10	we	-PRON-	PRP
cord-006229-7yoilsho	530	11	could	could	MD
cord-006229-7yoilsho	530	12	only	only	RB
cord-006229-7yoilsho	530	13	examine	examine	VB
cord-006229-7yoilsho	530	14	FOLIC	folic	NN
cord-006229-7yoilsho	530	15	in	in	IN
cord-006229-7yoilsho	530	16	relation	relation	NN
cord-006229-7yoilsho	530	17	to	to	IN
cord-006229-7yoilsho	530	18	OS+/FAA-	OS+/FAA-	NNP
cord-006229-7yoilsho	530	19	.	.	.
cord-006229-7yoilsho	531	1	Using	use	VBG
cord-006229-7yoilsho	531	2	OS-/FAA-/FOLIC+	OS-/FAA-/FOLIC+	NNP
cord-006229-7yoilsho	531	3	as	as	IN
cord-006229-7yoilsho	531	4	reference	reference	NN
cord-006229-7yoilsho	531	5	,	,	,
cord-006229-7yoilsho	531	6	we	-PRON-	PRP
cord-006229-7yoilsho	531	7	found	find	VBD
cord-006229-7yoilsho	531	8	the	the	DT
cord-006229-7yoilsho	531	9	highest	high	JJS
cord-006229-7yoilsho	531	10	risk	risk	NN
cord-006229-7yoilsho	531	11	with	with	IN
cord-006229-7yoilsho	531	12	OS+/FAA-/FOLICand	os+/faa-/folicand	CD
cord-006229-7yoilsho	531	13	a	a	DT
cord-006229-7yoilsho	531	14	lesser	less	JJR
cord-006229-7yoilsho	531	15	magnitude	magnitude	NN
cord-006229-7yoilsho	531	16	with	with	IN
cord-006229-7yoilsho	531	17	OS+/FAA-/FOLIC+	os+/faa-/folic+	CD
cord-006229-7yoilsho	532	1	(	(	-LRB-
cord-006229-7yoilsho	532	2	ORs	or	NNS
cord-006229-7yoilsho	532	3	being	be	VBG
cord-006229-7yoilsho	532	4	2	2	CD
cord-006229-7yoilsho	532	5	and	and	CC
cord-006229-7yoilsho	532	6	1.6	1.6	CD
cord-006229-7yoilsho	532	7	times	time	NNS
cord-006229-7yoilsho	532	8	respectively	respectively	RB
cord-006229-7yoilsho	532	9	for	for	IN
cord-006229-7yoilsho	532	10	both	both	DT
cord-006229-7yoilsho	532	11	controls	control	NNS
cord-006229-7yoilsho	532	12	)	)	-RRB-
cord-006229-7yoilsho	532	13	.	.	.
cord-006229-7yoilsho	533	1	Conclusion	conclusion	NN
cord-006229-7yoilsho	533	2	:	:	:
cord-006229-7yoilsho	534	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	534	2	study	study	NN
cord-006229-7yoilsho	534	3	suggests	suggest	VBZ
cord-006229-7yoilsho	534	4	an	an	DT
cord-006229-7yoilsho	534	5	increased	increase	VBN
cord-006229-7yoilsho	534	6	risk	risk	NN
cord-006229-7yoilsho	534	7	of	of	IN
cord-006229-7yoilsho	534	8	having	have	VBG
cord-006229-7yoilsho	534	9	a	a	DT
cord-006229-7yoilsho	534	10	child	child	NN
cord-006229-7yoilsho	534	11	with	with	IN
cord-006229-7yoilsho	534	12	nervous	nervous	JJ
cord-006229-7yoilsho	534	13	system	system	NN
cord-006229-7yoilsho	534	14	defects	defect	NNS
cord-006229-7yoilsho	534	15	in	in	IN
cord-006229-7yoilsho	534	16	mothers	mother	NNS
cord-006229-7yoilsho	534	17	who	who	WP
cord-006229-7yoilsho	534	18	were	be	VBD
cord-006229-7yoilsho	534	19	exposed	expose	VBN
cord-006229-7yoilsho	534	20	to	to	IN
cord-006229-7yoilsho	534	21	OS	os	NN
cord-006229-7yoilsho	534	22	-	-	HYPH
cord-006229-7yoilsho	534	23	inducing	induce	VBG
cord-006229-7yoilsho	534	24	drugs	drug	NNS
cord-006229-7yoilsho	534	25	during	during	IN
cord-006229-7yoilsho	534	26	pregnancy	pregnancy	NN
cord-006229-7yoilsho	534	27	,	,	,
cord-006229-7yoilsho	534	28	and	and	CC
cord-006229-7yoilsho	534	29	a	a	DT
cord-006229-7yoilsho	534	30	potential	potential	JJ
cord-006229-7yoilsho	534	31	risk	risk	NN
cord-006229-7yoilsho	534	32	reduction	reduction	NN
cord-006229-7yoilsho	534	33	with	with	IN
cord-006229-7yoilsho	534	34	FOLIC	folic	NN
cord-006229-7yoilsho	534	35	.	.	.
cord-006229-7yoilsho	535	1	Background	background	NN
cord-006229-7yoilsho	535	2	:	:	:
cord-006229-7yoilsho	536	1	Inhibition	inhibition	NN
cord-006229-7yoilsho	536	2	of	of	IN
cord-006229-7yoilsho	536	3	Rho	rho	NN
cord-006229-7yoilsho	536	4	-	-	HYPH
cord-006229-7yoilsho	536	5	GTPases	gtpase	NNS
cord-006229-7yoilsho	536	6	with	with	IN
cord-006229-7yoilsho	536	7	statins	statin	NNS
cord-006229-7yoilsho	536	8	as	as	RB
cord-006229-7yoilsho	536	9	well	well	RB
cord-006229-7yoilsho	536	10	as	as	IN
cord-006229-7yoilsho	536	11	specific	specific	JJ
cord-006229-7yoilsho	536	12	inhibition	inhibition	NN
cord-006229-7yoilsho	536	13	of	of	IN
cord-006229-7yoilsho	536	14	the	the	DT
cord-006229-7yoilsho	536	15	small	small	JJ
cord-006229-7yoilsho	536	16	GTPase	GTPase	NNP
cord-006229-7yoilsho	536	17	Rac1	Rac1	NNP
cord-006229-7yoilsho	536	18	protects	protect	VBZ
cord-006229-7yoilsho	536	19	non	non	JJ
cord-006229-7yoilsho	536	20	-	-	JJ
cord-006229-7yoilsho	536	21	transformed	transformed	JJ
cord-006229-7yoilsho	536	22	cells	cell	NNS
cord-006229-7yoilsho	536	23	from	from	IN
cord-006229-7yoilsho	536	24	topoisomerase	topoisomerase	NN
cord-006229-7yoilsho	536	25	II-(top2)-poisoninduced	II-(top2)-poisoninduced	NNP
cord-006229-7yoilsho	536	26	cleavable	cleavable	NNP
cord-006229-7yoilsho	536	27	complex	complex	JJ
cord-006229-7yoilsho	536	28	formation	formation	NN
cord-006229-7yoilsho	536	29	and	and	CC
cord-006229-7yoilsho	536	30	thereof	thereof	RB
cord-006229-7yoilsho	537	1	derived	derive	VBN
cord-006229-7yoilsho	537	2	DNA	DNA	NNP
cord-006229-7yoilsho	537	3	double	double	JJ
cord-006229-7yoilsho	537	4	-	-	HYPH
cord-006229-7yoilsho	537	5	strand	strand	NN
cord-006229-7yoilsho	537	6	breaks	break	NNS
cord-006229-7yoilsho	537	7	.	.	.
cord-006229-7yoilsho	538	1	This	this	DT
cord-006229-7yoilsho	538	2	effect	effect	NN
cord-006229-7yoilsho	538	3	rests	rest	VBZ
cord-006229-7yoilsho	538	4	at	at	IN
cord-006229-7yoilsho	538	5	least	least	JJS
cord-006229-7yoilsho	538	6	partially	partially	RB
cord-006229-7yoilsho	538	7	on	on	IN
cord-006229-7yoilsho	538	8	Rac1-mediated	rac1-mediate	VBN
cord-006229-7yoilsho	538	9	regulation	regulation	NN
cord-006229-7yoilsho	538	10	of	of	IN
cord-006229-7yoilsho	538	11	topoisomerase	topoisomerase	NN
cord-006229-7yoilsho	538	12	II	ii	CD
cord-006229-7yoilsho	538	13	activity	activity	NN
cord-006229-7yoilsho	538	14	.	.	.
cord-006229-7yoilsho	539	1	However	however	RB
cord-006229-7yoilsho	539	2	,	,	,
cord-006229-7yoilsho	539	3	the	the	DT
cord-006229-7yoilsho	539	4	link	link	NN
cord-006229-7yoilsho	539	5	between	between	IN
cord-006229-7yoilsho	539	6	Rac1	Rac1	NNP
cord-006229-7yoilsho	539	7	and	and	CC
cord-006229-7yoilsho	539	8	top2-poisoning	top2-poisoning	NNP
cord-006229-7yoilsho	539	9	is	be	VBZ
cord-006229-7yoilsho	539	10	only	only	RB
cord-006229-7yoilsho	539	11	poorly	poorly	RB
cord-006229-7yoilsho	539	12	understood	understand	VBN
cord-006229-7yoilsho	539	13	.	.	.
cord-006229-7yoilsho	540	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	540	2	,	,	,
cord-006229-7yoilsho	540	3	it	-PRON-	PRP
cord-006229-7yoilsho	540	4	is	be	VBZ
cord-006229-7yoilsho	540	5	unclear	unclear	JJ
cord-006229-7yoilsho	540	6	whether	whether	IN
cord-006229-7yoilsho	540	7	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	540	8	or	or	CC
cord-006229-7yoilsho	540	9	nuclear	nuclear	JJ
cord-006229-7yoilsho	540	10	type	type	NN
cord-006229-7yoilsho	540	11	II	ii	CD
cord-006229-7yoilsho	540	12	topoisomerases	topoisomerase	NNS
cord-006229-7yoilsho	540	13	are	be	VBP
cord-006229-7yoilsho	540	14	the	the	DT
cord-006229-7yoilsho	540	15	most	most	RBS
cord-006229-7yoilsho	540	16	relevant	relevant	JJ
cord-006229-7yoilsho	540	17	target	target	NN
cord-006229-7yoilsho	540	18	for	for	IN
cord-006229-7yoilsho	540	19	top2-poison	top2-poison	NN
cord-006229-7yoilsho	540	20	-	-	HYPH
cord-006229-7yoilsho	540	21	induced	induce	VBN
cord-006229-7yoilsho	540	22	cytotoxicity	cytotoxicity	NN
cord-006229-7yoilsho	540	23	.	.	.
cord-006229-7yoilsho	541	1	Here	here	RB
cord-006229-7yoilsho	541	2	,	,	,
cord-006229-7yoilsho	541	3	we	-PRON-	PRP
cord-006229-7yoilsho	541	4	investigated	investigate	VBD
cord-006229-7yoilsho	541	5	the	the	DT
cord-006229-7yoilsho	541	6	relevance	relevance	NN
cord-006229-7yoilsho	541	7	of	of	IN
cord-006229-7yoilsho	541	8	Rac1-regulated	rac1-regulate	VBN
cord-006229-7yoilsho	541	9	actin	actin	NN
cord-006229-7yoilsho	541	10	cytoskeleton	cytoskeleton	NN
cord-006229-7yoilsho	541	11	integrity	integrity	NN
cord-006229-7yoilsho	541	12	as	as	RB
cord-006229-7yoilsho	541	13	well	well	RB
cord-006229-7yoilsho	541	14	as	as	IN
cord-006229-7yoilsho	541	15	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	541	16	integrity	integrity	NN
cord-006229-7yoilsho	541	17	in	in	IN
cord-006229-7yoilsho	541	18	top2-poison	top2-poison	NNP
cord-006229-7yoilsho	541	19	-	-	HYPH
cord-006229-7yoilsho	541	20	induced	induce	VBN
cord-006229-7yoilsho	541	21	DNA	dna	NN
cord-006229-7yoilsho	541	22	damage	damage	NN
cord-006229-7yoilsho	541	23	responses	response	NNS
cord-006229-7yoilsho	541	24	as	as	RB
cord-006229-7yoilsho	541	25	well	well	RB
cord-006229-7yoilsho	541	26	as	as	IN
cord-006229-7yoilsho	541	27	cytotoxicity	cytotoxicity	NN
cord-006229-7yoilsho	541	28	under	under	IN
cord-006229-7yoilsho	541	29	situation	situation	NN
cord-006229-7yoilsho	541	30	of	of	IN
cord-006229-7yoilsho	541	31	Rac1	Rac1	NNP
cord-006229-7yoilsho	541	32	inhibition	inhibition	NN
cord-006229-7yoilsho	541	33	.	.	.
cord-006229-7yoilsho	542	1	Methods	method	NNS
cord-006229-7yoilsho	542	2	:	:	:
cord-006229-7yoilsho	542	3	Since	since	IN
cord-006229-7yoilsho	542	4	endothelial	endothelial	JJ
cord-006229-7yoilsho	542	5	cells	cell	NNS
cord-006229-7yoilsho	542	6	are	be	VBP
cord-006229-7yoilsho	542	7	the	the	DT
cord-006229-7yoilsho	542	8	first	first	JJ
cord-006229-7yoilsho	542	9	barrier	barrier	NN
cord-006229-7yoilsho	542	10	for	for	IN
cord-006229-7yoilsho	542	11	any	any	DT
cord-006229-7yoilsho	542	12	kind	kind	NN
cord-006229-7yoilsho	542	13	of	of	IN
cord-006229-7yoilsho	542	14	systemically	systemically	RB
cord-006229-7yoilsho	542	15	administered	administer	VBN
cord-006229-7yoilsho	542	16	chemicals	chemical	NNS
cord-006229-7yoilsho	542	17	and	and	CC
cord-006229-7yoilsho	542	18	cardiomyocytes	cardiomyocyte	NNS
cord-006229-7yoilsho	542	19	are	be	VBP
cord-006229-7yoilsho	542	20	particular	particular	RB
cord-006229-7yoilsho	542	21	sensitive	sensitive	JJ
cord-006229-7yoilsho	542	22	to	to	IN
cord-006229-7yoilsho	542	23	anthracyclines	anthracycline	NNS
cord-006229-7yoilsho	542	24	,	,	,
cord-006229-7yoilsho	542	25	endothelial	endothelial	JJ
cord-006229-7yoilsho	542	26	cells	cell	NNS
cord-006229-7yoilsho	542	27	(	(	-LRB-
cord-006229-7yoilsho	542	28	H5V	h5v	LS
cord-006229-7yoilsho	542	29	)	)	-RRB-
cord-006229-7yoilsho	542	30	as	as	RB
cord-006229-7yoilsho	542	31	well	well	RB
cord-006229-7yoilsho	542	32	as	as	IN
cord-006229-7yoilsho	542	33	cardiomyocytes	cardiomyocyte	NNS
cord-006229-7yoilsho	542	34	(	(	-LRB-
cord-006229-7yoilsho	542	35	H9c2	H9c2	NNP
cord-006229-7yoilsho	542	36	)	)	-RRB-
cord-006229-7yoilsho	542	37	were	be	VBD
cord-006229-7yoilsho	542	38	chosen	choose	VBN
cord-006229-7yoilsho	542	39	as	as	IN
cord-006229-7yoilsho	542	40	in	in	IN
cord-006229-7yoilsho	542	41	vitro	vitro	FW
cord-006229-7yoilsho	542	42	model	model	NN
cord-006229-7yoilsho	542	43	systems	system	NNS
cord-006229-7yoilsho	542	44	for	for	IN
cord-006229-7yoilsho	542	45	top2-poisoning	top2-poisoning	NNP
cord-006229-7yoilsho	542	46	.	.	.
cord-006229-7yoilsho	543	1	The	the	DT
cord-006229-7yoilsho	543	2	cells	cell	NNS
cord-006229-7yoilsho	543	3	were	be	VBD
cord-006229-7yoilsho	543	4	pre	pre	JJ
cord-006229-7yoilsho	543	5	-	-	VBN
cord-006229-7yoilsho	543	6	treated	treat	VBN
cord-006229-7yoilsho	543	7	with	with	IN
cord-006229-7yoilsho	543	8	Rac1	Rac1	NNP
cord-006229-7yoilsho	543	9	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	543	10	,	,	,
cord-006229-7yoilsho	543	11	statins	statin	NNS
cord-006229-7yoilsho	543	12	or	or	CC
cord-006229-7yoilsho	543	13	actin	actin	NN
cord-006229-7yoilsho	543	14	cytoskeleton	cytoskeleton	NN
cord-006229-7yoilsho	543	15	disruptors	disruptor	NNS
cord-006229-7yoilsho	543	16	and	and	CC
cord-006229-7yoilsho	543	17	were	be	VBD
cord-006229-7yoilsho	543	18	subsequently	subsequently	RB
cord-006229-7yoilsho	543	19	treated	treat	VBN
cord-006229-7yoilsho	543	20	with	with	IN
cord-006229-7yoilsho	543	21	the	the	DT
cord-006229-7yoilsho	543	22	topoisomerase	topoisomerase	NN
cord-006229-7yoilsho	543	23	II	ii	CD
cord-006229-7yoilsho	543	24	poisons	poison	NNS
cord-006229-7yoilsho	543	25	doxorubicin	doxorubicin	JJ
cord-006229-7yoilsho	543	26	or	or	CC
cord-006229-7yoilsho	543	27	etoposide	etoposide	RB
cord-006229-7yoilsho	543	28	.	.	.
cord-006229-7yoilsho	544	1	To	to	TO
cord-006229-7yoilsho	544	2	compare	compare	VB
cord-006229-7yoilsho	544	3	the	the	DT
cord-006229-7yoilsho	544	4	levels	level	NNS
cord-006229-7yoilsho	544	5	of	of	IN
cord-006229-7yoilsho	544	6	induced	induce	VBN
cord-006229-7yoilsho	544	7	DNA	dna	NN
cord-006229-7yoilsho	544	8	damage	damage	NN
cord-006229-7yoilsho	544	9	,	,	,
cord-006229-7yoilsho	544	10	γH2AX	γH2AX	NNP
cord-006229-7yoilsho	544	11	foci	foci	NN
cord-006229-7yoilsho	544	12	quantifications	quantification	NNS
cord-006229-7yoilsho	544	13	as	as	RB
cord-006229-7yoilsho	544	14	well	well	RB
cord-006229-7yoilsho	544	15	as	as	IN
cord-006229-7yoilsho	544	16	the	the	DT
cord-006229-7yoilsho	544	17	comet	comet	JJ
cord-006229-7yoilsho	544	18	assay	assay	NN
cord-006229-7yoilsho	544	19	were	be	VBD
cord-006229-7yoilsho	544	20	employed	employ	VBN
cord-006229-7yoilsho	544	21	.	.	.
cord-006229-7yoilsho	545	1	Actin	actin	NN
cord-006229-7yoilsho	545	2	disruption	disruption	NN
cord-006229-7yoilsho	545	3	was	be	VBD
cord-006229-7yoilsho	545	4	visualized	visualize	VBN
cord-006229-7yoilsho	545	5	by	by	IN
cord-006229-7yoilsho	545	6	phalloidin	phalloidin	NNS
cord-006229-7yoilsho	545	7	-	-	HYPH
cord-006229-7yoilsho	545	8	FITC	FITC	NNP
cord-006229-7yoilsho	545	9	staining	staining	NN
cord-006229-7yoilsho	545	10	.	.	.
cord-006229-7yoilsho	546	1	To	to	TO
cord-006229-7yoilsho	546	2	be	be	VB
cord-006229-7yoilsho	546	3	able	able	JJ
cord-006229-7yoilsho	546	4	to	to	TO
cord-006229-7yoilsho	546	5	detect	detect	VB
cord-006229-7yoilsho	546	6	relevant	relevant	JJ
cord-006229-7yoilsho	546	7	changes	change	NNS
cord-006229-7yoilsho	546	8	in	in	IN
cord-006229-7yoilsho	546	9	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	546	10	mass	mass	NN
cord-006229-7yoilsho	546	11	or	or	CC
cord-006229-7yoilsho	546	12	integrity	integrity	NN
cord-006229-7yoilsho	546	13	,	,	,
cord-006229-7yoilsho	546	14	high	high	JJ
cord-006229-7yoilsho	546	15	doses	dose	NNS
cord-006229-7yoilsho	546	16	of	of	IN
cord-006229-7yoilsho	546	17	top2-poisons	top2-poisons	NNPS
cord-006229-7yoilsho	546	18	had	have	VBD
cord-006229-7yoilsho	546	19	to	to	TO
cord-006229-7yoilsho	546	20	be	be	VB
cord-006229-7yoilsho	546	21	used	use	VBN
cord-006229-7yoilsho	546	22	in	in	IN
cord-006229-7yoilsho	546	23	both	both	DT
cord-006229-7yoilsho	546	24	cell	cell	NN
cord-006229-7yoilsho	546	25	lines	line	NNS
cord-006229-7yoilsho	546	26	.	.	.
cord-006229-7yoilsho	547	1	Changes	change	NNS
cord-006229-7yoilsho	547	2	in	in	IN
cord-006229-7yoilsho	547	3	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	547	4	homeostasis	homeostasis	NN
cord-006229-7yoilsho	547	5	as	as	RB
cord-006229-7yoilsho	547	6	well	well	RB
cord-006229-7yoilsho	547	7	as	as	IN
cord-006229-7yoilsho	547	8	integrity	integrity	NN
cord-006229-7yoilsho	547	9	were	be	VBD
cord-006229-7yoilsho	547	10	detected	detect	VBN
cord-006229-7yoilsho	547	11	by	by	IN
cord-006229-7yoilsho	547	12	the	the	DT
cord-006229-7yoilsho	547	13	JC1-assay	jc1-assay	NN
cord-006229-7yoilsho	547	14	,	,	,
cord-006229-7yoilsho	547	15	mitotracker	mitotracker	NNP
cord-006229-7yoilsho	547	16	assay	assay	NN
cord-006229-7yoilsho	547	17	as	as	RB
cord-006229-7yoilsho	547	18	well	well	RB
cord-006229-7yoilsho	547	19	as	as	IN
cord-006229-7yoilsho	547	20	ATP	ATP	NNP
cord-006229-7yoilsho	547	21	-	-	HYPH
cord-006229-7yoilsho	547	22	assay	assay	NN
cord-006229-7yoilsho	547	23	.	.	.
cord-006229-7yoilsho	548	1	Additionally	additionally	RB
cord-006229-7yoilsho	548	2	,	,	,
cord-006229-7yoilsho	548	3	PCR	PCR	NNP
cord-006229-7yoilsho	548	4	-	-	:
cord-006229-7yoilsho	548	5	and	and	CC
cord-006229-7yoilsho	548	6	gelelectrophoresis	gelelectrophoresis	NN
cord-006229-7yoilsho	548	7	-	-	HYPH
cord-006229-7yoilsho	548	8	based	base	VBN
cord-006229-7yoilsho	548	9	methods	method	NNS
cord-006229-7yoilsho	548	10	were	be	VBD
cord-006229-7yoilsho	548	11	used	use	VBN
cord-006229-7yoilsho	548	12	for	for	IN
cord-006229-7yoilsho	548	13	detecting	detect	VBG
cord-006229-7yoilsho	548	14	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	548	15	DNA	dna	NN
cord-006229-7yoilsho	548	16	damages	damage	NNS
cord-006229-7yoilsho	548	17	.	.	.
cord-006229-7yoilsho	549	1	Selected	select	VBN
cord-006229-7yoilsho	549	2	components	component	NNS
cord-006229-7yoilsho	549	3	of	of	IN
cord-006229-7yoilsho	549	4	the	the	DT
cord-006229-7yoilsho	549	5	DNA	dna	NN
cord-006229-7yoilsho	549	6	damage	damage	NN
cord-006229-7yoilsho	549	7	response	response	NN
cord-006229-7yoilsho	549	8	machinery	machinery	NN
cord-006229-7yoilsho	549	9	as	as	RB
cord-006229-7yoilsho	549	10	well	well	RB
cord-006229-7yoilsho	549	11	as	as	IN
cord-006229-7yoilsho	549	12	factors	factor	NNS
cord-006229-7yoilsho	549	13	of	of	IN
cord-006229-7yoilsho	549	14	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	549	15	homeostasis	homeostasis	NN
cord-006229-7yoilsho	549	16	were	be	VBD
cord-006229-7yoilsho	549	17	detected	detect	VBN
cord-006229-7yoilsho	549	18	by	by	IN
cord-006229-7yoilsho	549	19	Western	western	JJ
cord-006229-7yoilsho	549	20	Blot	blot	NN
cord-006229-7yoilsho	549	21	.	.	.
cord-006229-7yoilsho	550	1	Results	result	NNS
cord-006229-7yoilsho	550	2	:	:	:
cord-006229-7yoilsho	551	1	Disruption	disruption	NN
cord-006229-7yoilsho	551	2	of	of	IN
cord-006229-7yoilsho	551	3	the	the	DT
cord-006229-7yoilsho	551	4	integrity	integrity	NN
cord-006229-7yoilsho	551	5	of	of	IN
cord-006229-7yoilsho	551	6	the	the	DT
cord-006229-7yoilsho	551	7	actin	actin	NN
cord-006229-7yoilsho	551	8	cytoskeleton	cytoskeleton	NN
cord-006229-7yoilsho	551	9	attenuated	attenuate	VBD
cord-006229-7yoilsho	551	10	the	the	DT
cord-006229-7yoilsho	551	11	DNA	dna	NN
cord-006229-7yoilsho	551	12	damage	damage	NN
cord-006229-7yoilsho	551	13	response	response	NN
cord-006229-7yoilsho	551	14	to	to	IN
cord-006229-7yoilsho	551	15	a	a	DT
cord-006229-7yoilsho	551	16	similar	similar	JJ
cord-006229-7yoilsho	551	17	extent	extent	NN
cord-006229-7yoilsho	551	18	as	as	IN
cord-006229-7yoilsho	551	19	seen	see	VBN
cord-006229-7yoilsho	551	20	by	by	IN
cord-006229-7yoilsho	551	21	Rac1	Rac1	NNP
cord-006229-7yoilsho	551	22	inhibition	inhibition	NN
cord-006229-7yoilsho	551	23	,	,	,
cord-006229-7yoilsho	551	24	pointing	point	VBG
cord-006229-7yoilsho	551	25	to	to	IN
cord-006229-7yoilsho	551	26	a	a	DT
cord-006229-7yoilsho	551	27	role	role	NN
cord-006229-7yoilsho	551	28	of	of	IN
cord-006229-7yoilsho	551	29	actin	actin	NN
cord-006229-7yoilsho	551	30	filaments	filament	NNS
cord-006229-7yoilsho	551	31	in	in	IN
cord-006229-7yoilsho	551	32	the	the	DT
cord-006229-7yoilsho	551	33	DNA	dna	NN
cord-006229-7yoilsho	551	34	damage	damage	NN
cord-006229-7yoilsho	551	35	response	response	NN
cord-006229-7yoilsho	551	36	after	after	IN
cord-006229-7yoilsho	551	37	genotoxic	genotoxic	JJ
cord-006229-7yoilsho	551	38	insults	insult	NNS
cord-006229-7yoilsho	551	39	.	.	.
cord-006229-7yoilsho	552	1	The	the	DT
cord-006229-7yoilsho	552	2	actin	actin	NN
cord-006229-7yoilsho	552	3	cytoskeleton	cytoskeleton	NN
cord-006229-7yoilsho	552	4	seems	seem	VBZ
cord-006229-7yoilsho	552	5	to	to	TO
cord-006229-7yoilsho	552	6	participate	participate	VB
cord-006229-7yoilsho	552	7	in	in	IN
cord-006229-7yoilsho	552	8	genotoxin	genotoxin	NN
cord-006229-7yoilsho	552	9	-	-	HYPH
cord-006229-7yoilsho	552	10	induced	induce	VBN
cord-006229-7yoilsho	552	11	DNA	dna	NN
cord-006229-7yoilsho	552	12	damage	damage	NN
cord-006229-7yoilsho	552	13	,	,	,
cord-006229-7yoilsho	552	14	-repair	-repair	CD
cord-006229-7yoilsho	552	15	or	or	CC
cord-006229-7yoilsho	552	16	in	in	IN
cord-006229-7yoilsho	552	17	the	the	DT
cord-006229-7yoilsho	552	18	DNA	dna	NN
cord-006229-7yoilsho	552	19	damage	damage	NN
cord-006229-7yoilsho	552	20	response	response	NN
cord-006229-7yoilsho	552	21	as	as	IN
cord-006229-7yoilsho	552	22	reflected	reflect	VBN
cord-006229-7yoilsho	552	23	by	by	IN
cord-006229-7yoilsho	552	24	reduced	reduced	JJ
cord-006229-7yoilsho	552	25	numbers	number	NNS
cord-006229-7yoilsho	552	26	of	of	IN
cord-006229-7yoilsho	552	27	nuclear	nuclear	JJ
cord-006229-7yoilsho	552	28	H2AX	h2ax	NN
cord-006229-7yoilsho	552	29	-	-	HYPH
cord-006229-7yoilsho	552	30	foci	foci	NN
cord-006229-7yoilsho	552	31	as	as	RB
cord-006229-7yoilsho	552	32	well	well	RB
cord-006229-7yoilsho	552	33	as	as	IN
cord-006229-7yoilsho	552	34	the	the	DT
cord-006229-7yoilsho	552	35	comet	comet	JJ
cord-006229-7yoilsho	552	36	assay	assay	NN
cord-006229-7yoilsho	552	37	after	after	IN
cord-006229-7yoilsho	552	38	treatment	treatment	NN
cord-006229-7yoilsho	552	39	with	with	IN
cord-006229-7yoilsho	552	40	doxorubicin	doxorubicin	NN
cord-006229-7yoilsho	552	41	.	.	.
cord-006229-7yoilsho	553	1	This	this	DT
cord-006229-7yoilsho	553	2	was	be	VBD
cord-006229-7yoilsho	553	3	not	not	RB
cord-006229-7yoilsho	553	4	related	relate	VBN
cord-006229-7yoilsho	553	5	to	to	IN
cord-006229-7yoilsho	553	6	nuclear	nuclear	JJ
cord-006229-7yoilsho	553	7	import	import	NN
cord-006229-7yoilsho	553	8	or	or	CC
cord-006229-7yoilsho	553	9	export	export	NN
cord-006229-7yoilsho	553	10	of	of	IN
cord-006229-7yoilsho	553	11	doxorubicin	doxorubicin	NN
cord-006229-7yoilsho	553	12	.	.	.
cord-006229-7yoilsho	554	1	Disturbance	disturbance	NN
cord-006229-7yoilsho	554	2	of	of	IN
cord-006229-7yoilsho	554	3	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	554	4	homeostasis	homeostasis	NN
cord-006229-7yoilsho	554	5	or	or	CC
cord-006229-7yoilsho	554	6	integrity	integrity	NN
cord-006229-7yoilsho	554	7	was	be	VBD
cord-006229-7yoilsho	554	8	only	only	RB
cord-006229-7yoilsho	554	9	detectable	detectable	JJ
cord-006229-7yoilsho	554	10	at	at	IN
cord-006229-7yoilsho	554	11	high	high	JJ
cord-006229-7yoilsho	554	12	doses	dose	NNS
cord-006229-7yoilsho	554	13	of	of	IN
cord-006229-7yoilsho	554	14	topoisomerase	topoisomerase	NN
cord-006229-7yoilsho	554	15	II	ii	CD
cord-006229-7yoilsho	554	16	poisons	poison	NNS
cord-006229-7yoilsho	554	17	.	.	.
cord-006229-7yoilsho	555	1	This	this	DT
cord-006229-7yoilsho	555	2	was	be	VBD
cord-006229-7yoilsho	555	3	largely	largely	RB
cord-006229-7yoilsho	555	4	unaffected	unaffected	JJ
cord-006229-7yoilsho	555	5	by	by	IN
cord-006229-7yoilsho	555	6	pre	pre	JJ
cord-006229-7yoilsho	555	7	-	-	NN
cord-006229-7yoilsho	555	8	treatment	treatment	NN
cord-006229-7yoilsho	555	9	with	with	IN
cord-006229-7yoilsho	555	10	statins	statin	NNS
cord-006229-7yoilsho	555	11	or	or	CC
cord-006229-7yoilsho	556	1	Rac1-inhibitor	Rac1-inhibitor	NNP
cord-006229-7yoilsho	556	2	.	.	.
cord-006229-7yoilsho	557	1	Top2-poison	Top2-poison	NNP
cord-006229-7yoilsho	557	2	-	-	HYPH
cord-006229-7yoilsho	557	3	induced	induce	VBN
cord-006229-7yoilsho	557	4	raise	raise	NN
cord-006229-7yoilsho	557	5	in	in	IN
cord-006229-7yoilsho	557	6	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	557	7	mass	mass	NN
cord-006229-7yoilsho	557	8	was	be	VBD
cord-006229-7yoilsho	557	9	slightly	slightly	RB
cord-006229-7yoilsho	557	10	enhanced	enhance	VBN
cord-006229-7yoilsho	557	11	by	by	IN
cord-006229-7yoilsho	557	12	the	the	DT
cord-006229-7yoilsho	557	13	Rac1-inhibitor	Rac1-inhibitor	NNS
cord-006229-7yoilsho	557	14	and	and	CC
cord-006229-7yoilsho	557	15	statins	statin	NNS
cord-006229-7yoilsho	557	16	.	.	.
cord-006229-7yoilsho	558	1	Interestingly	interestingly	RB
cord-006229-7yoilsho	558	2	,	,	,
cord-006229-7yoilsho	558	3	inhibition	inhibition	NN
cord-006229-7yoilsho	558	4	of	of	IN
cord-006229-7yoilsho	558	5	Rac1	Rac1	NNP
cord-006229-7yoilsho	558	6	counteracted	counteract	VBN
cord-006229-7yoilsho	558	7	doxorubicin	doxorubicin	NN
cord-006229-7yoilsho	558	8	-	-	HYPH
cord-006229-7yoilsho	558	9	induced	induce	VBN
cord-006229-7yoilsho	558	10	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	558	11	of	of	IN
cord-006229-7yoilsho	558	12	the	the	DT
cord-006229-7yoilsho	558	13	AMP	amp	NN
cord-006229-7yoilsho	558	14	-	-	HYPH
cord-006229-7yoilsho	558	15	kinase	kinase	NN
cord-006229-7yoilsho	558	16	in	in	IN
cord-006229-7yoilsho	558	17	endothelial	endothelial	JJ
cord-006229-7yoilsho	558	18	cells	cell	NNS
cord-006229-7yoilsho	558	19	but	but	CC
cord-006229-7yoilsho	558	20	not	not	RB
cord-006229-7yoilsho	558	21	in	in	IN
cord-006229-7yoilsho	558	22	cardiomyocytes	cardiomyocyte	NNS
cord-006229-7yoilsho	558	23	.	.	.
cord-006229-7yoilsho	559	1	Conclusion	conclusion	NN
cord-006229-7yoilsho	559	2	:	:	:
cord-006229-7yoilsho	560	1	Mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	560	2	toxicity	toxicity	NN
cord-006229-7yoilsho	560	3	seems	seem	VBZ
cord-006229-7yoilsho	560	4	to	to	TO
cord-006229-7yoilsho	560	5	play	play	VB
cord-006229-7yoilsho	560	6	only	only	RB
cord-006229-7yoilsho	560	7	a	a	DT
cord-006229-7yoilsho	560	8	minor	minor	JJ
cord-006229-7yoilsho	560	9	role	role	NN
cord-006229-7yoilsho	560	10	in	in	IN
cord-006229-7yoilsho	560	11	top2-poisoninduced	top2-poisoninduced	NNP
cord-006229-7yoilsho	560	12	cytotoxicity	cytotoxicity	NN
cord-006229-7yoilsho	560	13	in	in	IN
cord-006229-7yoilsho	560	14	H9c2	H9c2	NNP
cord-006229-7yoilsho	560	15	and	and	CC
cord-006229-7yoilsho	560	16	H5V	h5v	NN
cord-006229-7yoilsho	560	17	cells	cell	NNS
cord-006229-7yoilsho	560	18	.	.	.
cord-006229-7yoilsho	561	1	The	the	DT
cord-006229-7yoilsho	561	2	data	datum	NNS
cord-006229-7yoilsho	561	3	point	point	NN
cord-006229-7yoilsho	561	4	to	to	IN
cord-006229-7yoilsho	561	5	a	a	DT
cord-006229-7yoilsho	561	6	role	role	NN
cord-006229-7yoilsho	561	7	of	of	IN
cord-006229-7yoilsho	561	8	Rac1-regulated	rac1-regulate	VBN
cord-006229-7yoilsho	561	9	filamentous	filamentous	JJ
cord-006229-7yoilsho	561	10	(	(	-LRB-
cord-006229-7yoilsho	561	11	nuclear	nuclear	JJ
cord-006229-7yoilsho	561	12	?	?	.
cord-006229-7yoilsho	561	13	)	)	-RRB-
cord-006229-7yoilsho	562	1	actin	actin	NN
cord-006229-7yoilsho	562	2	in	in	IN
cord-006229-7yoilsho	562	3	the	the	DT
cord-006229-7yoilsho	562	4	DNA	dna	NN
cord-006229-7yoilsho	562	5	repair	repair	NN
cord-006229-7yoilsho	562	6	and/or	and/or	CC
cord-006229-7yoilsho	562	7	DNA	dna	NN
cord-006229-7yoilsho	562	8	damage	damage	NN
cord-006229-7yoilsho	562	9	response	response	NN
cord-006229-7yoilsho	562	10	after	after	IN
cord-006229-7yoilsho	562	11	treatment	treatment	NN
cord-006229-7yoilsho	562	12	with	with	IN
cord-006229-7yoilsho	562	13	top2-poisons	top2-poison	NNS
cord-006229-7yoilsho	562	14	.	.	.
cord-006229-7yoilsho	563	1	Poly(ADP	poly(adp	NN
cord-006229-7yoilsho	563	2	-	-	HYPH
cord-006229-7yoilsho	563	3	ribose	ribose	NN
cord-006229-7yoilsho	563	4	)	)	-RRB-
cord-006229-7yoilsho	563	5	polymerase	polymerase	NN
cord-006229-7yoilsho	563	6	1	1	CD
cord-006229-7yoilsho	563	7	(	(	-LRB-
cord-006229-7yoilsho	563	8	PARP1	parp1	NN
cord-006229-7yoilsho	563	9	)	)	-RRB-
cord-006229-7yoilsho	563	10	and	and	CC
cord-006229-7yoilsho	563	11	the	the	DT
cord-006229-7yoilsho	563	12	RecQ	RecQ	NNP
cord-006229-7yoilsho	563	13	helicase	helicase	NN
cord-006229-7yoilsho	563	14	Werner	Werner	NNP
cord-006229-7yoilsho	563	15	syndrome	syndrome	NN
cord-006229-7yoilsho	563	16	protein	protein	NN
cord-006229-7yoilsho	563	17	(	(	-LRB-
cord-006229-7yoilsho	563	18	WRN	WRN	NNP
cord-006229-7yoilsho	563	19	)	)	-RRB-
cord-006229-7yoilsho	563	20	are	be	VBP
cord-006229-7yoilsho	563	21	important	important	JJ
cord-006229-7yoilsho	563	22	caretakers	caretaker	NNS
cord-006229-7yoilsho	563	23	of	of	IN
cord-006229-7yoilsho	563	24	the	the	DT
cord-006229-7yoilsho	563	25	genome	genome	NN
cord-006229-7yoilsho	563	26	.	.	.
cord-006229-7yoilsho	564	1	They	-PRON-	PRP
cord-006229-7yoilsho	564	2	physically	physically	RB
cord-006229-7yoilsho	564	3	interact	interact	VBP
cord-006229-7yoilsho	564	4	with	with	IN
cord-006229-7yoilsho	564	5	each	each	DT
cord-006229-7yoilsho	564	6	other	other	JJ
cord-006229-7yoilsho	564	7	and	and	CC
cord-006229-7yoilsho	564	8	are	be	VBP
cord-006229-7yoilsho	564	9	both	both	DT
cord-006229-7yoilsho	564	10	localized	localize	VBN
cord-006229-7yoilsho	564	11	in	in	IN
cord-006229-7yoilsho	564	12	the	the	DT
cord-006229-7yoilsho	564	13	nucleus	nucleus	NN
cord-006229-7yoilsho	564	14	and	and	CC
cord-006229-7yoilsho	564	15	in	in	IN
cord-006229-7yoilsho	564	16	particular	particular	JJ
cord-006229-7yoilsho	564	17	in	in	IN
cord-006229-7yoilsho	564	18	the	the	DT
cord-006229-7yoilsho	564	19	nucleoli	nucleoli	NNP
cord-006229-7yoilsho	564	20	.	.	.
cord-006229-7yoilsho	565	1	Both	both	DT
cord-006229-7yoilsho	565	2	participate	participate	VBP
cord-006229-7yoilsho	565	3	in	in	IN
cord-006229-7yoilsho	565	4	various	various	JJ
cord-006229-7yoilsho	565	5	overlapping	overlapping	JJ
cord-006229-7yoilsho	565	6	mechanisms	mechanism	NNS
cord-006229-7yoilsho	565	7	of	of	IN
cord-006229-7yoilsho	565	8	DNA	dna	NN
cord-006229-7yoilsho	565	9	metabolism	metabolism	NN
cord-006229-7yoilsho	565	10	,	,	,
cord-006229-7yoilsho	565	11	in	in	IN
cord-006229-7yoilsho	565	12	particular	particular	JJ
cord-006229-7yoilsho	565	13	genotoxic	genotoxic	JJ
cord-006229-7yoilsho	565	14	stress	stress	NN
cord-006229-7yoilsho	565	15	response	response	NN
cord-006229-7yoilsho	565	16	and	and	CC
cord-006229-7yoilsho	565	17	DNA	dna	NN
cord-006229-7yoilsho	565	18	repair	repair	NN
cord-006229-7yoilsho	565	19	[	[	-LRB-
cord-006229-7yoilsho	565	20	1	1	CD
cord-006229-7yoilsho	565	21	]	]	-RRB-
cord-006229-7yoilsho	565	22	.	.	.
cord-006229-7yoilsho	566	1	Previously	previously	RB
cord-006229-7yoilsho	566	2	,	,	,
cord-006229-7yoilsho	566	3	we	-PRON-	PRP
cord-006229-7yoilsho	566	4	and	and	CC
cord-006229-7yoilsho	566	5	others	other	NNS
cord-006229-7yoilsho	566	6	have	have	VBP
cord-006229-7yoilsho	566	7	shown	show	VBN
cord-006229-7yoilsho	566	8	in	in	IN
cord-006229-7yoilsho	566	9	biochemical	biochemical	JJ
cord-006229-7yoilsho	566	10	studies	study	NNS
cord-006229-7yoilsho	566	11	that	that	IN
cord-006229-7yoilsho	566	12	enzymatic	enzymatic	JJ
cord-006229-7yoilsho	566	13	functions	function	NNS
cord-006229-7yoilsho	566	14	of	of	IN
cord-006229-7yoilsho	566	15	WRN	WRN	NNP
cord-006229-7yoilsho	566	16	are	be	VBP
cord-006229-7yoilsho	566	17	regulated	regulate	VBN
cord-006229-7yoilsho	566	18	by	by	IN
cord-006229-7yoilsho	566	19	PARP1	PARP1	NNS
cord-006229-7yoilsho	566	20	as	as	RB
cord-006229-7yoilsho	566	21	well	well	RB
cord-006229-7yoilsho	566	22	as	as	IN
cord-006229-7yoilsho	566	23	by	by	IN
cord-006229-7yoilsho	566	24	non	non	JJ
cord-006229-7yoilsho	566	25	-	-	JJ
cord-006229-7yoilsho	566	26	covalent	covalent	JJ
cord-006229-7yoilsho	566	27	poly(ADP	poly(adp	NN
cord-006229-7yoilsho	566	28	-	-	HYPH
cord-006229-7yoilsho	566	29	ribose)-WRN	ribose)-wrn	NN
cord-006229-7yoilsho	566	30	interaction	interaction	NN
cord-006229-7yoilsho	566	31	[	[	-LRB-
cord-006229-7yoilsho	566	32	2	2	CD
cord-006229-7yoilsho	566	33	]	]	-RRB-
cord-006229-7yoilsho	566	34	[	[	-LRB-
cord-006229-7yoilsho	566	35	3	3	CD
cord-006229-7yoilsho	566	36	]	]	-RRB-
cord-006229-7yoilsho	566	37	[	[	-LRB-
cord-006229-7yoilsho	566	38	4	4	CD
cord-006229-7yoilsho	566	39	]	]	-RRB-
cord-006229-7yoilsho	566	40	.	.	.
cord-006229-7yoilsho	567	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	567	2	,	,	,
cord-006229-7yoilsho	567	3	pharmacological	pharmacological	JJ
cord-006229-7yoilsho	567	4	PARP	PARP	NNP
cord-006229-7yoilsho	567	5	inhibition	inhibition	NN
cord-006229-7yoilsho	567	6	as	as	RB
cord-006229-7yoilsho	567	7	well	well	RB
cord-006229-7yoilsho	567	8	as	as	IN
cord-006229-7yoilsho	567	9	a	a	DT
cord-006229-7yoilsho	567	10	genetic	genetic	JJ
cord-006229-7yoilsho	567	11	PARP1	parp1	NN
cord-006229-7yoilsho	567	12	ablation	ablation	NN
cord-006229-7yoilsho	567	13	in	in	IN
cord-006229-7yoilsho	567	14	HeLa	HeLa	NNP
cord-006229-7yoilsho	567	15	cells	cell	NNS
cord-006229-7yoilsho	567	16	alters	alter	VBZ
cord-006229-7yoilsho	567	17	the	the	DT
cord-006229-7yoilsho	567	18	recruitment	recruitment	NN
cord-006229-7yoilsho	567	19	kinetics	kinetics	NN
cord-006229-7yoilsho	567	20	of	of	IN
cord-006229-7yoilsho	567	21	WRN	WRN	NNP
cord-006229-7yoilsho	567	22	to	to	IN
cord-006229-7yoilsho	567	23	sites	site	NNS
cord-006229-7yoilsho	567	24	of	of	IN
cord-006229-7yoilsho	567	25	laser	laser	NN
cord-006229-7yoilsho	567	26	-	-	HYPH
cord-006229-7yoilsho	567	27	induced	induce	VBN
cord-006229-7yoilsho	567	28	DNA	dna	NN
cord-006229-7yoilsho	567	29	damage	damage	NN
cord-006229-7yoilsho	567	30	[	[	-LRB-
cord-006229-7yoilsho	567	31	5	5	CD
cord-006229-7yoilsho	567	32	]	]	-RRB-
cord-006229-7yoilsho	567	33	.	.	.
cord-006229-7yoilsho	568	1	Here	here	RB
cord-006229-7yoilsho	568	2	we	-PRON-	PRP
cord-006229-7yoilsho	568	3	report	report	VBP
cord-006229-7yoilsho	568	4	a	a	DT
cord-006229-7yoilsho	568	5	novel	novel	JJ
cord-006229-7yoilsho	568	6	role	role	NN
cord-006229-7yoilsho	568	7	for	for	IN
cord-006229-7yoilsho	568	8	PARP1	parp1	NN
cord-006229-7yoilsho	568	9	and	and	CC
cord-006229-7yoilsho	568	10	poly(ADP	poly(ADP	NNP
cord-006229-7yoilsho	568	11	-	-	HYPH
cord-006229-7yoilsho	568	12	ribosyl)ation	ribosyl)ation	NNP
cord-006229-7yoilsho	568	13	in	in	IN
cord-006229-7yoilsho	568	14	the	the	DT
cord-006229-7yoilsho	568	15	regulation	regulation	NN
cord-006229-7yoilsho	568	16	of	of	IN
cord-006229-7yoilsho	568	17	WRN	WRN	NNP
cord-006229-7yoilsho	568	18	's	's	POS
cord-006229-7yoilsho	568	19	subnuclear	subnuclear	JJ
cord-006229-7yoilsho	568	20	spatial	spatial	JJ
cord-006229-7yoilsho	568	21	distribution	distribution	NN
cord-006229-7yoilsho	568	22	upon	upon	IN
cord-006229-7yoilsho	568	23	induction	induction	NN
cord-006229-7yoilsho	568	24	of	of	IN
cord-006229-7yoilsho	568	25	oxidative	oxidative	JJ
cord-006229-7yoilsho	568	26	stress	stress	NN
cord-006229-7yoilsho	568	27	.	.	.
cord-006229-7yoilsho	569	1	We	-PRON-	PRP
cord-006229-7yoilsho	569	2	could	could	MD
cord-006229-7yoilsho	569	3	verify	verify	VB
cord-006229-7yoilsho	569	4	previous	previous	JJ
cord-006229-7yoilsho	569	5	reports	report	NNS
cord-006229-7yoilsho	569	6	that	that	IN
cord-006229-7yoilsho	569	7	WRN	WRN	NNP
cord-006229-7yoilsho	569	8	is	be	VBZ
cord-006229-7yoilsho	569	9	transiently	transiently	RB
cord-006229-7yoilsho	569	10	released	release	VBN
cord-006229-7yoilsho	569	11	from	from	IN
cord-006229-7yoilsho	569	12	nucleoli	nucleoli	NNP
cord-006229-7yoilsho	569	13	upon	upon	IN
cord-006229-7yoilsho	569	14	induction	induction	NN
cord-006229-7yoilsho	569	15	of	of	IN
cord-006229-7yoilsho	569	16	oxidative	oxidative	JJ
cord-006229-7yoilsho	569	17	stress	stress	NN
cord-006229-7yoilsho	569	18	,	,	,
cord-006229-7yoilsho	569	19	camptothecin	camptothecin	NNS
cord-006229-7yoilsho	569	20	(	(	-LRB-
cord-006229-7yoilsho	569	21	CPT	CPT	NNP
cord-006229-7yoilsho	569	22	)	)	-RRB-
cord-006229-7yoilsho	569	23	treatment	treatment	NN
cord-006229-7yoilsho	569	24	,	,	,
cord-006229-7yoilsho	569	25	and	and	CC
cord-006229-7yoilsho	569	26	laser	laser	NN
cord-006229-7yoilsho	569	27	-	-	HYPH
cord-006229-7yoilsho	569	28	induced	induce	VBN
cord-006229-7yoilsho	569	29	DNA	dna	NN
cord-006229-7yoilsho	569	30	damage	damage	NN
cord-006229-7yoilsho	569	31	in	in	IN
cord-006229-7yoilsho	569	32	a	a	DT
cord-006229-7yoilsho	569	33	time	time	NN
cord-006229-7yoilsho	569	34	-	-	HYPH
cord-006229-7yoilsho	569	35	dependent	dependent	JJ
cord-006229-7yoilsho	569	36	manner	manner	NN
cord-006229-7yoilsho	569	37	.	.	.
cord-006229-7yoilsho	570	1	While	while	IN
cord-006229-7yoilsho	570	2	,	,	,
cord-006229-7yoilsho	570	3	CPT	CPT	NNP
cord-006229-7yoilsho	570	4	-	-	HYPH
cord-006229-7yoilsho	570	5	induced	induce	VBN
cord-006229-7yoilsho	570	6	translocation	translocation	NN
cord-006229-7yoilsho	570	7	appears	appear	VBZ
cord-006229-7yoilsho	570	8	to	to	TO
cord-006229-7yoilsho	570	9	be	be	VB
cord-006229-7yoilsho	570	10	a	a	DT
cord-006229-7yoilsho	570	11	PARPindependent	parpindependent	NN
cord-006229-7yoilsho	570	12	process	process	NN
cord-006229-7yoilsho	570	13	,	,	,
cord-006229-7yoilsho	570	14	our	-PRON-	PRP$
cord-006229-7yoilsho	570	15	results	result	NNS
cord-006229-7yoilsho	570	16	reveal	reveal	VBP
cord-006229-7yoilsho	570	17	that	that	IN
cord-006229-7yoilsho	570	18	upon	upon	IN
cord-006229-7yoilsho	570	19	H	h	NN
cord-006229-7yoilsho	570	20	2	2	CD
cord-006229-7yoilsho	570	21	O	o	NN
cord-006229-7yoilsho	570	22	2	2	CD
cord-006229-7yoilsho	570	23	-induced	-induced	JJ
cord-006229-7yoilsho	570	24	oxidative	oxidative	JJ
cord-006229-7yoilsho	570	25	stress	stress	NN
cord-006229-7yoilsho	570	26	,	,	,
cord-006229-7yoilsho	570	27	PARP1	PARP1	NNP
cord-006229-7yoilsho	570	28	is	be	VBZ
cord-006229-7yoilsho	570	29	essential	essential	JJ
cord-006229-7yoilsho	570	30	for	for	IN
cord-006229-7yoilsho	570	31	the	the	DT
cord-006229-7yoilsho	570	32	translocation	translocation	NN
cord-006229-7yoilsho	570	33	of	of	IN
cord-006229-7yoilsho	570	34	WRN	WRN	NNP
cord-006229-7yoilsho	570	35	from	from	IN
cord-006229-7yoilsho	570	36	the	the	DT
cord-006229-7yoilsho	570	37	nucleoli	nucleoli	NNP
cord-006229-7yoilsho	570	38	to	to	IN
cord-006229-7yoilsho	570	39	the	the	DT
cord-006229-7yoilsho	570	40	nucleoplasm	nucleoplasm	NN
cord-006229-7yoilsho	570	41	.	.	.
cord-006229-7yoilsho	571	1	PARP1	PARP1	NNP
cord-006229-7yoilsho	571	2	activity	activity	NN
cord-006229-7yoilsho	571	3	only	only	RB
cord-006229-7yoilsho	571	4	partially	partially	RB
cord-006229-7yoilsho	571	5	contributes	contribute	VBZ
cord-006229-7yoilsho	571	6	to	to	IN
cord-006229-7yoilsho	571	7	WRN	WRN	NNP
cord-006229-7yoilsho	571	8	release	release	NN
cord-006229-7yoilsho	571	9	from	from	IN
cord-006229-7yoilsho	571	10	nucleoli	nucleoli	NNP
cord-006229-7yoilsho	571	11	,	,	,
cord-006229-7yoilsho	571	12	underlining	underline	VBG
cord-006229-7yoilsho	571	13	the	the	DT
cord-006229-7yoilsho	571	14	importance	importance	NN
cord-006229-7yoilsho	571	15	of	of	IN
cord-006229-7yoilsho	571	16	a	a	DT
cord-006229-7yoilsho	571	17	direct	direct	JJ
cord-006229-7yoilsho	571	18	WRN	WRN	NNP
cord-006229-7yoilsho	571	19	-	-	HYPH
cord-006229-7yoilsho	571	20	PARP1	parp1	NN
cord-006229-7yoilsho	571	21	interaction	interaction	NN
cord-006229-7yoilsho	571	22	for	for	IN
cord-006229-7yoilsho	571	23	subnuclear	subnuclear	JJ
cord-006229-7yoilsho	571	24	WRN	WRN	NNP
cord-006229-7yoilsho	571	25	redistribution	redistribution	NN
cord-006229-7yoilsho	571	26	.	.	.
cord-006229-7yoilsho	572	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	572	2	,	,	,
cord-006229-7yoilsho	572	3	we	-PRON-	PRP
cord-006229-7yoilsho	572	4	identified	identify	VBD
cord-006229-7yoilsho	572	5	a	a	DT
cord-006229-7yoilsho	572	6	novel	novel	JJ
cord-006229-7yoilsho	572	7	PAR	par	NN
cord-006229-7yoilsho	572	8	-	-	HYPH
cord-006229-7yoilsho	572	9	binding	bind	VBG
cord-006229-7yoilsho	572	10	motif	motif	NN
cord-006229-7yoilsho	572	11	within	within	IN
cord-006229-7yoilsho	572	12	the	the	DT
cord-006229-7yoilsho	572	13	WRN	WRN	NNP
cord-006229-7yoilsho	572	14	sequence	sequence	NN
cord-006229-7yoilsho	572	15	that	that	WDT
cord-006229-7yoilsho	572	16	is	be	VBZ
cord-006229-7yoilsho	572	17	located	locate	VBN
cord-006229-7yoilsho	572	18	in	in	IN
cord-006229-7yoilsho	572	19	its	-PRON-	PRP$
cord-006229-7yoilsho	572	20	RQC	RQC	NNP
cord-006229-7yoilsho	572	21	domain	domain	NN
cord-006229-7yoilsho	572	22	,	,	,
cord-006229-7yoilsho	572	23	which	which	WDT
cord-006229-7yoilsho	572	24	also	also	RB
cord-006229-7yoilsho	572	25	harbors	harbor	VBZ
cord-006229-7yoilsho	572	26	the	the	DT
cord-006229-7yoilsho	572	27	binding	binding	NN
cord-006229-7yoilsho	572	28	site	site	NN
cord-006229-7yoilsho	572	29	for	for	IN
cord-006229-7yoilsho	572	30	PARP1	parp1	NN
cord-006229-7yoilsho	572	31	and	and	CC
cord-006229-7yoilsho	572	32	is	be	VBZ
cord-006229-7yoilsho	572	33	necessary	necessary	JJ
cord-006229-7yoilsho	572	34	for	for	IN
cord-006229-7yoilsho	572	35	WRN	WRN	NNP
cord-006229-7yoilsho	572	36	's	's	POS
cord-006229-7yoilsho	572	37	nucleolar	nucleolar	JJ
cord-006229-7yoilsho	572	38	localization	localization	NN
cord-006229-7yoilsho	572	39	under	under	IN
cord-006229-7yoilsho	572	40	non	non	JJ
cord-006229-7yoilsho	572	41	-	-	JJ
cord-006229-7yoilsho	572	42	stress	stress	JJ
cord-006229-7yoilsho	572	43	conditions	condition	NNS
cord-006229-7yoilsho	572	44	.	.	.
cord-006229-7yoilsho	573	1	Currently	currently	RB
cord-006229-7yoilsho	573	2	,	,	,
cord-006229-7yoilsho	573	3	we	-PRON-	PRP
cord-006229-7yoilsho	573	4	are	be	VBP
cord-006229-7yoilsho	573	5	testing	test	VBG
cord-006229-7yoilsho	573	6	corresponding	correspond	VBG
cord-006229-7yoilsho	573	7	WRN	WRN	NNP
cord-006229-7yoilsho	573	8	mutants	mutant	NNS
cord-006229-7yoilsho	573	9	to	to	TO
cord-006229-7yoilsho	573	10	analyze	analyze	VB
cord-006229-7yoilsho	573	11	if	if	IN
cord-006229-7yoilsho	573	12	this	this	DT
cord-006229-7yoilsho	573	13	region	region	NN
cord-006229-7yoilsho	573	14	is	be	VBZ
cord-006229-7yoilsho	573	15	responsible	responsible	JJ
cord-006229-7yoilsho	573	16	for	for	IN
cord-006229-7yoilsho	573	17	the	the	DT
cord-006229-7yoilsho	573	18	PARP1-dependent	PARP1-dependent	NNP
cord-006229-7yoilsho	573	19	release	release	NN
cord-006229-7yoilsho	573	20	of	of	IN
cord-006229-7yoilsho	573	21	WRN	WRN	NNP
cord-006229-7yoilsho	573	22	from	from	IN
cord-006229-7yoilsho	573	23	nucleoli	nucleoli	NNP
cord-006229-7yoilsho	573	24	to	to	IN
cord-006229-7yoilsho	573	25	sites	site	NNS
cord-006229-7yoilsho	573	26	of	of	IN
cord-006229-7yoilsho	573	27	DNA	dna	NN
cord-006229-7yoilsho	573	28	damage	damage	NN
cord-006229-7yoilsho	573	29	.	.	.
cord-006229-7yoilsho	574	1	In	in	IN
cord-006229-7yoilsho	574	2	conclusion	conclusion	NN
cord-006229-7yoilsho	574	3	,	,	,
cord-006229-7yoilsho	574	4	we	-PRON-	PRP
cord-006229-7yoilsho	574	5	provide	provide	VBP
cord-006229-7yoilsho	574	6	novel	novel	JJ
cord-006229-7yoilsho	574	7	insight	insight	NN
cord-006229-7yoilsho	574	8	into	into	IN
cord-006229-7yoilsho	574	9	the	the	DT
cord-006229-7yoilsho	574	10	role	role	NN
cord-006229-7yoilsho	574	11	of	of	IN
cord-006229-7yoilsho	574	12	PARP1	parp1	NN
cord-006229-7yoilsho	574	13	in	in	IN
cord-006229-7yoilsho	574	14	WRN	WRN	NNP
cord-006229-7yoilsho	574	15	's	's	POS
cord-006229-7yoilsho	574	16	spatio	spatio	JJ
cord-006229-7yoilsho	574	17	-	-	HYPH
cord-006229-7yoilsho	574	18	temporal	temporal	JJ
cord-006229-7yoilsho	574	19	regulation	regulation	NN
cord-006229-7yoilsho	574	20	in	in	IN
cord-006229-7yoilsho	574	21	the	the	DT
cord-006229-7yoilsho	574	22	nucleus	nucleus	NN
cord-006229-7yoilsho	574	23	during	during	IN
cord-006229-7yoilsho	574	24	the	the	DT
cord-006229-7yoilsho	574	25	oxidative	oxidative	JJ
cord-006229-7yoilsho	574	26	stress	stress	NN
cord-006229-7yoilsho	574	27	response	response	NN
cord-006229-7yoilsho	574	28	.	.	.
cord-006229-7yoilsho	575	1	Host	host	NN
cord-006229-7yoilsho	575	2	-	-	HYPH
cord-006229-7yoilsho	575	3	cell	cell	NN
cord-006229-7yoilsho	575	4	reactivation	reactivation	NN
cord-006229-7yoilsho	575	5	(	(	-LRB-
cord-006229-7yoilsho	575	6	HCR	HCR	NNP
cord-006229-7yoilsho	575	7	)	)	-RRB-
cord-006229-7yoilsho	575	8	is	be	VBZ
cord-006229-7yoilsho	575	9	an	an	DT
cord-006229-7yoilsho	575	10	assay	assay	NN
cord-006229-7yoilsho	575	11	used	use	VBN
cord-006229-7yoilsho	575	12	to	to	TO
cord-006229-7yoilsho	575	13	determine	determine	VB
cord-006229-7yoilsho	575	14	DNA	dna	NN
cord-006229-7yoilsho	575	15	repair	repair	NN
cord-006229-7yoilsho	575	16	capacity	capacity	NN
cord-006229-7yoilsho	575	17	of	of	IN
cord-006229-7yoilsho	575	18	cells	cell	NNS
cord-006229-7yoilsho	575	19	.	.	.
cord-006229-7yoilsho	576	1	In	in	IN
cord-006229-7yoilsho	576	2	its	-PRON-	PRP$
cord-006229-7yoilsho	576	3	canonical	canonical	JJ
cord-006229-7yoilsho	576	4	layout	layout	NN
cord-006229-7yoilsho	576	5	,	,	,
cord-006229-7yoilsho	576	6	the	the	DT
cord-006229-7yoilsho	576	7	test	test	NN
cord-006229-7yoilsho	576	8	utilised	utilise	VBD
cord-006229-7yoilsho	576	9	a	a	DT
cord-006229-7yoilsho	576	10	virus	virus	NN
cord-006229-7yoilsho	576	11	or	or	CC
cord-006229-7yoilsho	576	12	a	a	DT
cord-006229-7yoilsho	576	13	plasmid	plasmid	NN
cord-006229-7yoilsho	576	14	with	with	IN
cord-006229-7yoilsho	576	15	a	a	DT
cord-006229-7yoilsho	576	16	marker	marker	NN
cord-006229-7yoilsho	576	17	gene	gene	NN
cord-006229-7yoilsho	576	18	,	,	,
cord-006229-7yoilsho	576	19	inactivated	inactivate	VBN
cord-006229-7yoilsho	576	20	by	by	IN
cord-006229-7yoilsho	576	21	UV	uv	NN
cord-006229-7yoilsho	576	22	-	-	HYPH
cord-006229-7yoilsho	576	23	damage	damage	NN
cord-006229-7yoilsho	576	24	[	[	-LRB-
cord-006229-7yoilsho	576	25	1	1	CD
cord-006229-7yoilsho	576	26	,	,	,
cord-006229-7yoilsho	576	27	2	2	CD
cord-006229-7yoilsho	576	28	]	]	-RRB-
cord-006229-7yoilsho	576	29	.	.	.
cord-006229-7yoilsho	577	1	Among	among	IN
cord-006229-7yoilsho	577	2	the	the	DT
cord-006229-7yoilsho	577	3	infected	infected	JJ
cord-006229-7yoilsho	577	4	or	or	CC
cord-006229-7yoilsho	577	5	transfected	transfecte	VBN
cord-006229-7yoilsho	577	6	host	host	NN
cord-006229-7yoilsho	577	7	cells	cell	NNS
cord-006229-7yoilsho	577	8	types	type	NNS
cord-006229-7yoilsho	577	9	,	,	,
cord-006229-7yoilsho	577	10	only	only	RB
cord-006229-7yoilsho	577	11	those	those	DT
cord-006229-7yoilsho	577	12	with	with	IN
cord-006229-7yoilsho	577	13	functional	functional	JJ
cord-006229-7yoilsho	577	14	DNA	dna	NN
cord-006229-7yoilsho	577	15	repair	repair	NN
cord-006229-7yoilsho	577	16	pathway	pathway	NN
cord-006229-7yoilsho	577	17	would	would	MD
cord-006229-7yoilsho	577	18	re	re	VB
cord-006229-7yoilsho	577	19	-	-	VB
cord-006229-7yoilsho	577	20	activate	activate	VB
cord-006229-7yoilsho	577	21	the	the	DT
cord-006229-7yoilsho	577	22	damaged	damage	VBN
cord-006229-7yoilsho	577	23	DNA	dna	NN
cord-006229-7yoilsho	577	24	,	,	,
cord-006229-7yoilsho	577	25	thus	thus	RB
cord-006229-7yoilsho	577	26	providing	provide	VBG
cord-006229-7yoilsho	577	27	a	a	DT
cord-006229-7yoilsho	577	28	rationale	rationale	NN
cord-006229-7yoilsho	577	29	for	for	IN
cord-006229-7yoilsho	577	30	identification	identification	NN
cord-006229-7yoilsho	577	31	of	of	IN
cord-006229-7yoilsho	577	32	DNA	dna	NN
cord-006229-7yoilsho	577	33	repair	repair	NN
cord-006229-7yoilsho	577	34	genes	gene	NNS
cord-006229-7yoilsho	577	35	in	in	IN
cord-006229-7yoilsho	577	36	the	the	DT
cord-006229-7yoilsho	577	37	mutant	mutant	JJ
cord-006229-7yoilsho	577	38	screens	screen	NNS
cord-006229-7yoilsho	577	39	.	.	.
cord-006229-7yoilsho	578	1	An	an	DT
cord-006229-7yoilsho	578	2	obvious	obvious	JJ
cord-006229-7yoilsho	578	3	advantage	advantage	NN
cord-006229-7yoilsho	578	4	of	of	IN
cord-006229-7yoilsho	578	5	HCR	HCR	NNP
cord-006229-7yoilsho	578	6	is	be	VBZ
cord-006229-7yoilsho	578	7	that	that	IN
cord-006229-7yoilsho	578	8	repair	repair	NN
cord-006229-7yoilsho	578	9	can	can	MD
cord-006229-7yoilsho	578	10	be	be	VB
cord-006229-7yoilsho	578	11	measured	measure	VBN
cord-006229-7yoilsho	578	12	in	in	IN
cord-006229-7yoilsho	578	13	cells	cell	NNS
cord-006229-7yoilsho	578	14	that	that	WDT
cord-006229-7yoilsho	578	15	have	have	VBP
cord-006229-7yoilsho	578	16	not	not	RB
cord-006229-7yoilsho	578	17	been	be	VBN
cord-006229-7yoilsho	578	18	exposed	expose	VBN
cord-006229-7yoilsho	578	19	to	to	IN
cord-006229-7yoilsho	578	20	a	a	DT
cord-006229-7yoilsho	578	21	damaging	damaging	JJ
cord-006229-7yoilsho	578	22	agent	agent	NN
cord-006229-7yoilsho	578	23	.	.	.
cord-006229-7yoilsho	579	1	However	however	RB
cord-006229-7yoilsho	579	2	,	,	,
cord-006229-7yoilsho	579	3	because	because	IN
cord-006229-7yoilsho	579	4	of	of	IN
cord-006229-7yoilsho	579	5	multiple	multiple	JJ
cord-006229-7yoilsho	579	6	variables	variable	NNS
cord-006229-7yoilsho	579	7	of	of	IN
cord-006229-7yoilsho	579	8	the	the	DT
cord-006229-7yoilsho	579	9	damage	damage	NN
cord-006229-7yoilsho	579	10	generation	generation	NN
cord-006229-7yoilsho	579	11	,	,	,
cord-006229-7yoilsho	579	12	transfection	transfection	NN
cord-006229-7yoilsho	579	13	and	and	CC
cord-006229-7yoilsho	579	14	interpretation	interpretation	NN
cord-006229-7yoilsho	579	15	of	of	IN
cord-006229-7yoilsho	579	16	results	result	NNS
cord-006229-7yoilsho	579	17	,	,	,
cord-006229-7yoilsho	579	18	the	the	DT
cord-006229-7yoilsho	579	19	assay	assay	NN
cord-006229-7yoilsho	579	20	has	have	VBZ
cord-006229-7yoilsho	579	21	been	be	VBN
cord-006229-7yoilsho	579	22	hard	hard	JJ
cord-006229-7yoilsho	579	23	to	to	TO
cord-006229-7yoilsho	579	24	harmonise	harmonise	VB
cord-006229-7yoilsho	579	25	and	and	CC
cord-006229-7yoilsho	579	26	develop	develop	VB
cord-006229-7yoilsho	579	27	into	into	IN
cord-006229-7yoilsho	579	28	a	a	DT
cord-006229-7yoilsho	579	29	widely	widely	RB
cord-006229-7yoilsho	579	30	accepted	accept	VBN
cord-006229-7yoilsho	579	31	quantitative	quantitative	JJ
cord-006229-7yoilsho	579	32	DNA	dna	NN
cord-006229-7yoilsho	579	33	repair	repair	NN
cord-006229-7yoilsho	579	34	assay	assay	NN
cord-006229-7yoilsho	579	35	.	.	.
cord-006229-7yoilsho	580	1	Over	over	IN
cord-006229-7yoilsho	580	2	the	the	DT
cord-006229-7yoilsho	580	3	last	last	JJ
cord-006229-7yoilsho	580	4	years	year	NNS
cord-006229-7yoilsho	580	5	,	,	,
cord-006229-7yoilsho	580	6	my	-PRON-	PRP$
cord-006229-7yoilsho	580	7	team	team	NN
cord-006229-7yoilsho	580	8	has	have	VBZ
cord-006229-7yoilsho	580	9	developed	develop	VBN
cord-006229-7yoilsho	580	10	and	and	CC
cord-006229-7yoilsho	580	11	validated	validate	VBD
cord-006229-7yoilsho	580	12	several	several	JJ
cord-006229-7yoilsho	580	13	major	major	JJ
cord-006229-7yoilsho	580	14	improvements	improvement	NNS
cord-006229-7yoilsho	580	15	of	of	IN
cord-006229-7yoilsho	580	16	the	the	DT
cord-006229-7yoilsho	580	17	mammalian	mammalian	JJ
cord-006229-7yoilsho	580	18	HCR	HCR	NNP
cord-006229-7yoilsho	580	19	assay	assay	NN
cord-006229-7yoilsho	580	20	.	.	.
cord-006229-7yoilsho	581	1	Exploiting	exploit	VBG
cord-006229-7yoilsho	581	2	sequence	sequence	NN
cord-006229-7yoilsho	581	3	-	-	HYPH
cord-006229-7yoilsho	581	4	specific	specific	JJ
cord-006229-7yoilsho	581	5	nicking	nicking	NN
cord-006229-7yoilsho	581	6	endonucleases	endonuclease	NNS
cord-006229-7yoilsho	581	7	and	and	CC
cord-006229-7yoilsho	581	8	customised	customised	JJ
cord-006229-7yoilsho	581	9	design	design	NN
cord-006229-7yoilsho	581	10	of	of	IN
cord-006229-7yoilsho	581	11	the	the	DT
cord-006229-7yoilsho	581	12	reporter	reporter	NN
cord-006229-7yoilsho	581	13	vectors	vector	NNS
cord-006229-7yoilsho	581	14	,	,	,
cord-006229-7yoilsho	581	15	we	-PRON-	PRP
cord-006229-7yoilsho	581	16	proposed	propose	VBD
cord-006229-7yoilsho	581	17	an	an	DT
cord-006229-7yoilsho	581	18	innovative	innovative	JJ
cord-006229-7yoilsho	581	19	and	and	CC
cord-006229-7yoilsho	581	20	very	very	RB
cord-006229-7yoilsho	581	21	efficient	efficient	JJ
cord-006229-7yoilsho	581	22	technique	technique	NN
cord-006229-7yoilsho	581	23	for	for	IN
cord-006229-7yoilsho	581	24	incorporation	incorporation	NN
cord-006229-7yoilsho	581	25	of	of	IN
cord-006229-7yoilsho	581	26	synthetic	synthetic	JJ
cord-006229-7yoilsho	581	27	oligonucleotides	oligonucleotide	NNS
cord-006229-7yoilsho	581	28	,	,	,
cord-006229-7yoilsho	581	29	containing	contain	VBG
cord-006229-7yoilsho	581	30	single	single	RB
cord-006229-7yoilsho	581	31	structurally	structurally	RB
cord-006229-7yoilsho	581	32	defined	define	VBN
cord-006229-7yoilsho	581	33	DNA	dna	NN
cord-006229-7yoilsho	581	34	base	base	NN
cord-006229-7yoilsho	581	35	and	and	CC
cord-006229-7yoilsho	581	36	backbone	backbone	NN
cord-006229-7yoilsho	581	37	modifications	modification	NNS
cord-006229-7yoilsho	581	38	,	,	,
cord-006229-7yoilsho	581	39	into	into	IN
cord-006229-7yoilsho	581	40	desired	desire	VBN
cord-006229-7yoilsho	581	41	gene	gene	NN
cord-006229-7yoilsho	581	42	elements	element	NNS
cord-006229-7yoilsho	581	43	[	[	-LRB-
cord-006229-7yoilsho	581	44	3	3	CD
cord-006229-7yoilsho	581	45	]	]	-RRB-
cord-006229-7yoilsho	581	46	.	.	.
cord-006229-7yoilsho	582	1	This	this	DT
cord-006229-7yoilsho	582	2	ad	ad	FW
cord-006229-7yoilsho	582	3	hoc	hoc	FW
cord-006229-7yoilsho	582	4	approach	approach	NN
cord-006229-7yoilsho	582	5	allows	allow	VBZ
cord-006229-7yoilsho	582	6	examination	examination	NN
cord-006229-7yoilsho	582	7	of	of	IN
cord-006229-7yoilsho	582	8	the	the	DT
cord-006229-7yoilsho	582	9	repair	repair	NN
cord-006229-7yoilsho	582	10	in	in	IN
cord-006229-7yoilsho	582	11	a	a	DT
cord-006229-7yoilsho	582	12	stand	stand	VB
cord-006229-7yoilsho	582	13	-	-	HYPH
cord-006229-7yoilsho	582	14	specific	specific	JJ
cord-006229-7yoilsho	582	15	manner	manner	NN
cord-006229-7yoilsho	582	16	and	and	CC
cord-006229-7yoilsho	582	17	at	at	IN
cord-006229-7yoilsho	582	18	single	single	JJ
cord-006229-7yoilsho	582	19	nucleotide	nucleotide	JJ
cord-006229-7yoilsho	582	20	resolution	resolution	NN
cord-006229-7yoilsho	582	21	.	.	.
cord-006229-7yoilsho	583	1	We	-PRON-	PRP
cord-006229-7yoilsho	583	2	efficiently	efficiently	RB
cord-006229-7yoilsho	583	3	applied	apply	VBD
cord-006229-7yoilsho	583	4	HCR	HCR	NNP
cord-006229-7yoilsho	583	5	in	in	IN
cord-006229-7yoilsho	583	6	its	-PRON-	PRP$
cord-006229-7yoilsho	583	7	new	new	JJ
cord-006229-7yoilsho	583	8	layout	layout	NN
cord-006229-7yoilsho	583	9	for	for	IN
cord-006229-7yoilsho	583	10	measurement	measurement	NN
cord-006229-7yoilsho	583	11	of	of	IN
cord-006229-7yoilsho	583	12	the	the	DT
cord-006229-7yoilsho	583	13	nucleotide	nucleotide	JJ
cord-006229-7yoilsho	583	14	excision	excision	NN
cord-006229-7yoilsho	583	15	repair	repair	NN
cord-006229-7yoilsho	583	16	of	of	IN
cord-006229-7yoilsho	583	17	various	various	JJ
cord-006229-7yoilsho	583	18	DNA	dna	NN
cord-006229-7yoilsho	583	19	adducts	adduct	NNS
cord-006229-7yoilsho	583	20	.	.	.
cord-006229-7yoilsho	584	1	Moreover	moreover	RB
cord-006229-7yoilsho	584	2	,	,	,
cord-006229-7yoilsho	584	3	we	-PRON-	PRP
cord-006229-7yoilsho	584	4	demonstrated	demonstrate	VBD
cord-006229-7yoilsho	584	5	that	that	IN
cord-006229-7yoilsho	584	6	the	the	DT
cord-006229-7yoilsho	584	7	enhanced	enhance	VBN
cord-006229-7yoilsho	584	8	HCR	HCR	NNP
cord-006229-7yoilsho	584	9	assay	assay	NN
cord-006229-7yoilsho	584	10	can	can	MD
cord-006229-7yoilsho	584	11	differentiate	differentiate	VB
cord-006229-7yoilsho	584	12	between	between	IN
cord-006229-7yoilsho	584	13	the	the	DT
cord-006229-7yoilsho	584	14	transcription	transcription	NN
cord-006229-7yoilsho	584	15	-	-	HYPH
cord-006229-7yoilsho	584	16	coupled	couple	VBN
cord-006229-7yoilsho	584	17	(	(	-LRB-
cord-006229-7yoilsho	584	18	TC	TC	NNP
cord-006229-7yoilsho	584	19	-	-	HYPH
cord-006229-7yoilsho	584	20	NER	NER	NNP
cord-006229-7yoilsho	584	21	)	)	-RRB-
cord-006229-7yoilsho	584	22	and	and	CC
cord-006229-7yoilsho	584	23	global	global	JJ
cord-006229-7yoilsho	584	24	genome	genome	NN
cord-006229-7yoilsho	585	1	(	(	-LRB-
cord-006229-7yoilsho	585	2	GG	GG	NNP
cord-006229-7yoilsho	585	3	-	-	HYPH
cord-006229-7yoilsho	585	4	NER	NER	NNP
cord-006229-7yoilsho	585	5	)	)	-RRB-
cord-006229-7yoilsho	585	6	subpathways	subpathway	NNS
cord-006229-7yoilsho	585	7	of	of	IN
cord-006229-7yoilsho	585	8	NER	NER	NNP
cord-006229-7yoilsho	585	9	[	[	-LRB-
cord-006229-7yoilsho	585	10	4	4	CD
cord-006229-7yoilsho	585	11	]	]	-RRB-
cord-006229-7yoilsho	585	12	.	.	.
cord-006229-7yoilsho	586	1	We	-PRON-	PRP
cord-006229-7yoilsho	586	2	further	further	RB
cord-006229-7yoilsho	586	3	obtained	obtain	VBD
cord-006229-7yoilsho	586	4	new	new	JJ
cord-006229-7yoilsho	586	5	significant	significant	JJ
cord-006229-7yoilsho	586	6	insights	insight	NNS
cord-006229-7yoilsho	586	7	into	into	IN
cord-006229-7yoilsho	586	8	the	the	DT
cord-006229-7yoilsho	586	9	lesion	lesion	NN
cord-006229-7yoilsho	586	10	-	-	HYPH
cord-006229-7yoilsho	586	11	specific	specific	JJ
cord-006229-7yoilsho	586	12	mechanisms	mechanism	NNS
cord-006229-7yoilsho	586	13	of	of	IN
cord-006229-7yoilsho	586	14	base	base	NN
cord-006229-7yoilsho	586	15	excision	excision	NN
cord-006229-7yoilsho	586	16	repair	repair	NN
cord-006229-7yoilsho	586	17	of	of	IN
cord-006229-7yoilsho	586	18	several	several	JJ
cord-006229-7yoilsho	586	19	endogenously	endogenously	RB
cord-006229-7yoilsho	586	20	occurring	occur	VBG
cord-006229-7yoilsho	586	21	aberrant	aberrant	JJ
cord-006229-7yoilsho	586	22	DNA	dna	NN
cord-006229-7yoilsho	586	23	bases	basis	NNS
cord-006229-7yoilsho	586	24	[	[	-LRB-
cord-006229-7yoilsho	586	25	5	5	CD
cord-006229-7yoilsho	586	26	-7	-7	CD
cord-006229-7yoilsho	586	27	]	]	-RRB-
cord-006229-7yoilsho	586	28	and	and	CC
cord-006229-7yoilsho	586	29	plan	plan	VBP
cord-006229-7yoilsho	586	30	to	to	TO
cord-006229-7yoilsho	586	31	adapt	adapt	VB
cord-006229-7yoilsho	586	32	the	the	DT
cord-006229-7yoilsho	586	33	assay	assay	NN
cord-006229-7yoilsho	586	34	to	to	IN
cord-006229-7yoilsho	586	35	the	the	DT
cord-006229-7yoilsho	586	36	detection	detection	NN
cord-006229-7yoilsho	586	37	of	of	IN
cord-006229-7yoilsho	586	38	mismatch	mismatch	NN
cord-006229-7yoilsho	586	39	repair	repair	NN
cord-006229-7yoilsho	586	40	and	and	CC
cord-006229-7yoilsho	586	41	translesion	translesion	NN
cord-006229-7yoilsho	586	42	DNA	dna	NN
cord-006229-7yoilsho	586	43	synthesis	synthesis	NN
cord-006229-7yoilsho	586	44	.	.	.
cord-006229-7yoilsho	587	1	In	in	IN
cord-006229-7yoilsho	587	2	addition	addition	NN
cord-006229-7yoilsho	587	3	to	to	IN
cord-006229-7yoilsho	587	4	the	the	DT
cord-006229-7yoilsho	587	5	applications	application	NNS
cord-006229-7yoilsho	587	6	in	in	IN
cord-006229-7yoilsho	587	7	the	the	DT
cord-006229-7yoilsho	587	8	DNA	dna	NN
cord-006229-7yoilsho	587	9	repair	repair	NN
cord-006229-7yoilsho	587	10	field	field	NN
cord-006229-7yoilsho	587	11	,	,	,
cord-006229-7yoilsho	587	12	the	the	DT
cord-006229-7yoilsho	587	13	enhanced	enhance	VBN
cord-006229-7yoilsho	587	14	HCR	HCR	NNP
cord-006229-7yoilsho	587	15	assay	assay	NN
cord-006229-7yoilsho	587	16	provides	provide	VBZ
cord-006229-7yoilsho	587	17	a	a	DT
cord-006229-7yoilsho	587	18	tool	tool	NN
cord-006229-7yoilsho	587	19	for	for	IN
cord-006229-7yoilsho	587	20	investigation	investigation	NN
cord-006229-7yoilsho	587	21	of	of	IN
cord-006229-7yoilsho	587	22	the	the	DT
cord-006229-7yoilsho	587	23	dynamics	dynamic	NNS
cord-006229-7yoilsho	587	24	and	and	CC
cord-006229-7yoilsho	587	25	transcriptional	transcriptional	JJ
cord-006229-7yoilsho	587	26	impact	impact	NN
cord-006229-7yoilsho	587	27	of	of	IN
cord-006229-7yoilsho	587	28	the	the	DT
cord-006229-7yoilsho	587	29	regulatory	regulatory	JJ
cord-006229-7yoilsho	587	30	DNA	dna	NN
cord-006229-7yoilsho	587	31	bases	basis	NNS
cord-006229-7yoilsho	587	32	5methylcytosine	5methylcytosine	CD
cord-006229-7yoilsho	587	33	and	and	CC
cord-006229-7yoilsho	587	34	5-hydroxymethylcytosine	5-hydroxymethylcytosine	CD
cord-006229-7yoilsho	587	35	as	as	RB
cord-006229-7yoilsho	587	36	well	well	RB
cord-006229-7yoilsho	587	37	as	as	IN
cord-006229-7yoilsho	587	38	their	-PRON-	PRP$
cord-006229-7yoilsho	587	39	derivatives	derivative	NNS
cord-006229-7yoilsho	587	40	(	(	-LRB-
cord-006229-7yoilsho	587	41	5formylcytosine	5formylcytosine	CD
cord-006229-7yoilsho	587	42	and	and	CC
cord-006229-7yoilsho	587	43	5-carboxycytosine	5-carboxycytosine	CD
cord-006229-7yoilsho	587	44	A	a	DT
cord-006229-7yoilsho	587	45	coordinated	coordinated	JJ
cord-006229-7yoilsho	587	46	and	and	CC
cord-006229-7yoilsho	587	47	faithful	faithful	JJ
cord-006229-7yoilsho	587	48	DNA	dna	NN
cord-006229-7yoilsho	587	49	damage	damage	NN
cord-006229-7yoilsho	587	50	response	response	NN
cord-006229-7yoilsho	587	51	is	be	VBZ
cord-006229-7yoilsho	587	52	of	of	IN
cord-006229-7yoilsho	587	53	central	central	JJ
cord-006229-7yoilsho	587	54	importance	importance	NN
cord-006229-7yoilsho	587	55	for	for	IN
cord-006229-7yoilsho	587	56	maintaining	maintain	VBG
cord-006229-7yoilsho	587	57	genomic	genomic	JJ
cord-006229-7yoilsho	587	58	integrity	integrity	NN
cord-006229-7yoilsho	587	59	and	and	CC
cord-006229-7yoilsho	587	60	cell	cell	NN
cord-006229-7yoilsho	587	61	survival	survival	NN
cord-006229-7yoilsho	587	62	.	.	.
cord-006229-7yoilsho	588	1	Transcriptional	transcriptional	JJ
cord-006229-7yoilsho	588	2	activation	activation	NN
cord-006229-7yoilsho	588	3	of	of	IN
cord-006229-7yoilsho	588	4	DNA	dna	NN
cord-006229-7yoilsho	588	5	repair	repair	NN
cord-006229-7yoilsho	588	6	genes	gene	NNS
cord-006229-7yoilsho	588	7	is	be	VBZ
cord-006229-7yoilsho	588	8	an	an	DT
cord-006229-7yoilsho	588	9	important	important	JJ
cord-006229-7yoilsho	588	10	regulatory	regulatory	JJ
cord-006229-7yoilsho	588	11	mechanism	mechanism	NN
cord-006229-7yoilsho	588	12	contributing	contribute	VBG
cord-006229-7yoilsho	588	13	to	to	IN
cord-006229-7yoilsho	588	14	the	the	DT
cord-006229-7yoilsho	588	15	adaptation	adaptation	NN
cord-006229-7yoilsho	588	16	of	of	IN
cord-006229-7yoilsho	588	17	cells	cell	NNS
cord-006229-7yoilsho	588	18	to	to	IN
cord-006229-7yoilsho	588	19	genotoxic	genotoxic	JJ
cord-006229-7yoilsho	588	20	stress	stress	NN
cord-006229-7yoilsho	588	21	and	and	CC
cord-006229-7yoilsho	588	22	protection	protection	NN
cord-006229-7yoilsho	588	23	against	against	IN
cord-006229-7yoilsho	588	24	genotoxin	genotoxin	NN
cord-006229-7yoilsho	588	25	-	-	HYPH
cord-006229-7yoilsho	588	26	mediated	mediate	VBN
cord-006229-7yoilsho	588	27	cell	cell	NN
cord-006229-7yoilsho	588	28	death	death	NN
cord-006229-7yoilsho	588	29	.	.	.
cord-006229-7yoilsho	589	1	Here	here	RB
cord-006229-7yoilsho	589	2	we	-PRON-	PRP
cord-006229-7yoilsho	589	3	show	show	VBP
cord-006229-7yoilsho	589	4	that	that	IN
cord-006229-7yoilsho	589	5	exposure	exposure	NN
cord-006229-7yoilsho	589	6	to	to	IN
cord-006229-7yoilsho	589	7	a	a	DT
cord-006229-7yoilsho	589	8	low	low	JJ
cord-006229-7yoilsho	589	9	dose	dose	NN
cord-006229-7yoilsho	589	10	of	of	IN
cord-006229-7yoilsho	589	11	benzo(a)pyrene	benzo(a)pyrene	NN
cord-006229-7yoilsho	589	12	9	9	CD
cord-006229-7yoilsho	589	13	,	,	,
cord-006229-7yoilsho	589	14	,	,	,
cord-006229-7yoilsho	589	15	the	the	DT
cord-006229-7yoilsho	589	16	active	active	JJ
cord-006229-7yoilsho	589	17	metabolite	metabolite	NN
cord-006229-7yoilsho	589	18	of	of	IN
cord-006229-7yoilsho	589	19	benzo(a)pyrene	benzo(a)pyrene	NN
cord-006229-7yoilsho	589	20	(	(	-LRB-
cord-006229-7yoilsho	589	21	B[a]P	B[a]P	NNP
cord-006229-7yoilsho	589	22	)	)	-RRB-
cord-006229-7yoilsho	589	23	,	,	,
cord-006229-7yoilsho	589	24	which	which	WDT
cord-006229-7yoilsho	589	25	represents	represent	VBZ
cord-006229-7yoilsho	589	26	the	the	DT
cord-006229-7yoilsho	589	27	most	most	RBS
cord-006229-7yoilsho	589	28	important	important	JJ
cord-006229-7yoilsho	589	29	carcinogen	carcinogen	NN
cord-006229-7yoilsho	589	30	formed	form	VBN
cord-006229-7yoilsho	589	31	by	by	IN
cord-006229-7yoilsho	589	32	incomplete	incomplete	JJ
cord-006229-7yoilsho	589	33	combustion	combustion	NN
cord-006229-7yoilsho	589	34	during	during	IN
cord-006229-7yoilsho	589	35	food	food	NN
cord-006229-7yoilsho	589	36	preparation	preparation	NN
cord-006229-7yoilsho	589	37	and	and	CC
cord-006229-7yoilsho	589	38	smoking	smoking	NN
cord-006229-7yoilsho	589	39	,	,	,
cord-006229-7yoilsho	589	40	causes	cause	VBZ
cord-006229-7yoilsho	589	41	upregulation	upregulation	NN
cord-006229-7yoilsho	589	42	of	of	IN
cord-006229-7yoilsho	589	43	several	several	JJ
cord-006229-7yoilsho	589	44	DNA	dna	NN
cord-006229-7yoilsho	589	45	repair	repair	NN
cord-006229-7yoilsho	589	46	genes	gene	NNS
cord-006229-7yoilsho	589	47	.	.	.
cord-006229-7yoilsho	590	1	Combined	combined	JJ
cord-006229-7yoilsho	590	2	induction	induction	NN
cord-006229-7yoilsho	590	3	of	of	IN
cord-006229-7yoilsho	590	4	the	the	DT
cord-006229-7yoilsho	590	5	nucleotide	nucleotide	JJ
cord-006229-7yoilsho	590	6	excision	excision	NN
cord-006229-7yoilsho	590	7	repair	repair	NN
cord-006229-7yoilsho	590	8	(	(	-LRB-
cord-006229-7yoilsho	590	9	NER	NER	NNP
cord-006229-7yoilsho	590	10	)	)	-RRB-
cord-006229-7yoilsho	590	11	genes	gene	VBZ
cord-006229-7yoilsho	590	12	DDB2	DDB2	NNP
cord-006229-7yoilsho	590	13	,	,	,
cord-006229-7yoilsho	590	14	XPC	XPC	NNP
cord-006229-7yoilsho	590	15	,	,	,
cord-006229-7yoilsho	590	16	XPF	XPF	NNP
cord-006229-7yoilsho	590	17	and	and	CC
cord-006229-7yoilsho	590	18	XPG	XPG	NNP
cord-006229-7yoilsho	590	19	enhanced	enhance	VBN
cord-006229-7yoilsho	590	20	repair	repair	NN
cord-006229-7yoilsho	590	21	activity	activity	NN
cord-006229-7yoilsho	590	22	and	and	CC
cord-006229-7yoilsho	590	23	protected	protect	VBN
cord-006229-7yoilsho	590	24	cells	cell	NNS
cord-006229-7yoilsho	590	25	against	against	IN
cord-006229-7yoilsho	590	26	a	a	DT
cord-006229-7yoilsho	590	27	subsequent	subsequent	JJ
cord-006229-7yoilsho	590	28	BPDE	BPDE	NNP
cord-006229-7yoilsho	590	29	exposure	exposure	NN
cord-006229-7yoilsho	590	30	.	.	.
cord-006229-7yoilsho	591	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	591	2	induction	induction	NN
cord-006229-7yoilsho	591	3	of	of	IN
cord-006229-7yoilsho	591	4	the	the	DT
cord-006229-7yoilsho	591	5	translesion	translesion	NN
cord-006229-7yoilsho	591	6	polymerase	polymerase	NN
cord-006229-7yoilsho	591	7	POLH	POLH	NNP
cord-006229-7yoilsho	591	8	was	be	VBD
cord-006229-7yoilsho	591	9	also	also	RB
cord-006229-7yoilsho	591	10	involved	involve	VBN
cord-006229-7yoilsho	591	11	in	in	IN
cord-006229-7yoilsho	591	12	protection	protection	NN
cord-006229-7yoilsho	591	13	against	against	IN
cord-006229-7yoilsho	591	14	BPDE	BPDE	NNP
cord-006229-7yoilsho	591	15	-	-	HYPH
cord-006229-7yoilsho	591	16	induced	induce	VBN
cord-006229-7yoilsho	591	17	apoptosis	apoptosis	NN
cord-006229-7yoilsho	591	18	,	,	,
cord-006229-7yoilsho	591	19	however	however	RB
cord-006229-7yoilsho	591	20	led	lead	VBN
cord-006229-7yoilsho	591	21	to	to	IN
cord-006229-7yoilsho	591	22	an	an	DT
cord-006229-7yoilsho	591	23	enhanced	enhance	VBN
cord-006229-7yoilsho	591	24	mutation	mutation	NN
cord-006229-7yoilsho	591	25	frequency	frequency	NN
cord-006229-7yoilsho	591	26	in	in	IN
cord-006229-7yoilsho	591	27	the	the	DT
cord-006229-7yoilsho	591	28	surviving	survive	VBG
cord-006229-7yoilsho	591	29	cells	cell	NNS
cord-006229-7yoilsho	591	30	.	.	.
cord-006229-7yoilsho	592	1	Activation	activation	NN
cord-006229-7yoilsho	592	2	of	of	IN
cord-006229-7yoilsho	592	3	these	these	DT
cord-006229-7yoilsho	592	4	DNA	dna	NN
cord-006229-7yoilsho	592	5	repair	repair	NN
cord-006229-7yoilsho	592	6	pathways	pathway	NNS
cord-006229-7yoilsho	592	7	was	be	VBD
cord-006229-7yoilsho	592	8	also	also	RB
cord-006229-7yoilsho	592	9	observed	observe	VBN
cord-006229-7yoilsho	592	10	upon	upon	IN
cord-006229-7yoilsho	592	11	exposure	exposure	NN
cord-006229-7yoilsho	592	12	to	to	IN
cord-006229-7yoilsho	592	13	B[a]P	B[a]P	NNP
cord-006229-7yoilsho	592	14	and	and	CC
cord-006229-7yoilsho	592	15	in	in	IN
cord-006229-7yoilsho	592	16	vivo	vivo	NN
cord-006229-7yoilsho	592	17	in	in	IN
cord-006229-7yoilsho	592	18	buccal	buccal	JJ
cord-006229-7yoilsho	592	19	cells	cell	NNS
cord-006229-7yoilsho	592	20	of	of	IN
cord-006229-7yoilsho	592	21	male	male	JJ
cord-006229-7yoilsho	592	22	individuals	individual	NNS
cord-006229-7yoilsho	592	23	upon	upon	IN
cord-006229-7yoilsho	592	24	smoking	smoking	NN
cord-006229-7yoilsho	592	25	,	,	,
cord-006229-7yoilsho	592	26	indicating	indicate	VBG
cord-006229-7yoilsho	592	27	that	that	IN
cord-006229-7yoilsho	592	28	this	this	DT
cord-006229-7yoilsho	592	29	mechanism	mechanism	NN
cord-006229-7yoilsho	592	30	may	may	MD
cord-006229-7yoilsho	592	31	be	be	VB
cord-006229-7yoilsho	592	32	involved	involve	VBN
cord-006229-7yoilsho	592	33	in	in	IN
cord-006229-7yoilsho	592	34	the	the	DT
cord-006229-7yoilsho	592	35	formation	formation	NN
cord-006229-7yoilsho	592	36	of	of	IN
cord-006229-7yoilsho	592	37	smoking	smoking	NN
cord-006229-7yoilsho	592	38	-	-	HYPH
cord-006229-7yoilsho	592	39	related	relate	VBN
cord-006229-7yoilsho	592	40	cancers	cancer	NNS
cord-006229-7yoilsho	592	41	.	.	.
cord-006229-7yoilsho	593	1	Altogether	altogether	RB
cord-006229-7yoilsho	593	2	,	,	,
cord-006229-7yoilsho	593	3	we	-PRON-	PRP
cord-006229-7yoilsho	593	4	could	could	MD
cord-006229-7yoilsho	593	5	show	show	VB
cord-006229-7yoilsho	593	6	that	that	IN
cord-006229-7yoilsho	593	7	low	low	JJ
cord-006229-7yoilsho	593	8	-	-	HYPH
cord-006229-7yoilsho	593	9	dose	dose	NN
cord-006229-7yoilsho	593	10	BPDE	BPDE	NNP
cord-006229-7yoilsho	593	11	exposure	exposure	NN
cord-006229-7yoilsho	593	12	activates	activate	VBZ
cord-006229-7yoilsho	593	13	a	a	DT
cord-006229-7yoilsho	593	14	complex	complex	JJ
cord-006229-7yoilsho	593	15	network	network	NN
cord-006229-7yoilsho	593	16	of	of	IN
cord-006229-7yoilsho	593	17	transcriptional	transcriptional	JJ
cord-006229-7yoilsho	593	18	alterations	alteration	NNS
cord-006229-7yoilsho	593	19	,	,	,
cord-006229-7yoilsho	593	20	leading	lead	VBG
cord-006229-7yoilsho	593	21	to	to	IN
cord-006229-7yoilsho	593	22	protection	protection	NN
cord-006229-7yoilsho	593	23	against	against	IN
cord-006229-7yoilsho	593	24	cell	cell	NN
cord-006229-7yoilsho	593	25	death	death	NN
cord-006229-7yoilsho	593	26	,	,	,
cord-006229-7yoilsho	593	27	at	at	IN
cord-006229-7yoilsho	593	28	the	the	DT
cord-006229-7yoilsho	593	29	cost	cost	NN
cord-006229-7yoilsho	593	30	of	of	IN
cord-006229-7yoilsho	593	31	increased	increase	VBN
cord-006229-7yoilsho	593	32	mutation	mutation	NN
cord-006229-7yoilsho	593	33	frequency	frequency	NN
cord-006229-7yoilsho	593	34	,	,	,
cord-006229-7yoilsho	593	35	highlighting	highlight	VBG
cord-006229-7yoilsho	593	36	the	the	DT
cord-006229-7yoilsho	593	37	danger	danger	NN
cord-006229-7yoilsho	593	38	of	of	IN
cord-006229-7yoilsho	593	39	occasional	occasional	JJ
cord-006229-7yoilsho	593	40	smoking	smoking	NN
cord-006229-7yoilsho	593	41	.	.	.
cord-006229-7yoilsho	594	1	Poly(ADP	Poly(ADP	NNP
cord-006229-7yoilsho	594	2	-	-	HYPH
cord-006229-7yoilsho	594	3	ribosyl)ation	ribosyl)ation	NNP
cord-006229-7yoilsho	594	4	(	(	-LRB-
cord-006229-7yoilsho	594	5	PARylation	parylation	NN
cord-006229-7yoilsho	594	6	)	)	-RRB-
cord-006229-7yoilsho	594	7	is	be	VBZ
cord-006229-7yoilsho	594	8	an	an	DT
cord-006229-7yoilsho	594	9	essential	essential	JJ
cord-006229-7yoilsho	594	10	posttranslational	posttranslational	JJ
cord-006229-7yoilsho	594	11	modification	modification	NN
cord-006229-7yoilsho	594	12	with	with	IN
cord-006229-7yoilsho	594	13	the	the	DT
cord-006229-7yoilsho	594	14	biopolymer	biopolymer	NN
cord-006229-7yoilsho	594	15	poly(ADP	poly(adp	NN
cord-006229-7yoilsho	594	16	-	-	HYPH
cord-006229-7yoilsho	594	17	ribose	ribose	NN
cord-006229-7yoilsho	594	18	)	)	-RRB-
cord-006229-7yoilsho	595	1	(	(	-LRB-
cord-006229-7yoilsho	595	2	PAR	PAR	NNP
cord-006229-7yoilsho	595	3	)	)	-RRB-
cord-006229-7yoilsho	595	4	.	.	.
cord-006229-7yoilsho	596	1	The	the	DT
cord-006229-7yoilsho	596	2	reaction	reaction	NN
cord-006229-7yoilsho	596	3	is	be	VBZ
cord-006229-7yoilsho	596	4	catalyzed	catalyze	VBN
cord-006229-7yoilsho	596	5	by	by	IN
cord-006229-7yoilsho	596	6	poly(ADP	poly(adp	NN
cord-006229-7yoilsho	596	7	-	-	HYPH
cord-006229-7yoilsho	596	8	ribose	ribose	NN
cord-006229-7yoilsho	596	9	)	)	-RRB-
cord-006229-7yoilsho	596	10	polymerases	polymerase	NNS
cord-006229-7yoilsho	596	11	(	(	-LRB-
cord-006229-7yoilsho	596	12	PARPs	PARPs	NNPS
cord-006229-7yoilsho	596	13	)	)	-RRB-
cord-006229-7yoilsho	596	14	and	and	CC
cord-006229-7yoilsho	596	15	plays	play	VBZ
cord-006229-7yoilsho	596	16	key	key	JJ
cord-006229-7yoilsho	596	17	roles	role	NNS
cord-006229-7yoilsho	596	18	in	in	IN
cord-006229-7yoilsho	596	19	cellular	cellular	JJ
cord-006229-7yoilsho	596	20	physiology	physiology	NN
cord-006229-7yoilsho	596	21	and	and	CC
cord-006229-7yoilsho	596	22	stress	stress	NN
cord-006229-7yoilsho	596	23	response	response	NN
cord-006229-7yoilsho	596	24	by	by	IN
cord-006229-7yoilsho	596	25	regulating	regulate	VBG
cord-006229-7yoilsho	596	26	physico	physico	NN
cord-006229-7yoilsho	596	27	-	-	HYPH
cord-006229-7yoilsho	596	28	chemical	chemical	NN
cord-006229-7yoilsho	596	29	properties	property	NNS
cord-006229-7yoilsho	596	30	of	of	IN
cord-006229-7yoilsho	596	31	target	target	NN
cord-006229-7yoilsho	596	32	proteins	protein	NNS
cord-006229-7yoilsho	596	33	.	.	.
cord-006229-7yoilsho	597	1	Of	of	IN
cord-006229-7yoilsho	597	2	the	the	DT
cord-006229-7yoilsho	597	3	17	17	CD
cord-006229-7yoilsho	597	4	members	member	NNS
cord-006229-7yoilsho	597	5	of	of	IN
cord-006229-7yoilsho	597	6	the	the	DT
cord-006229-7yoilsho	597	7	human	human	JJ
cord-006229-7yoilsho	597	8	PARP	PARP	NNP
cord-006229-7yoilsho	597	9	gene	gene	NN
cord-006229-7yoilsho	597	10	family	family	NN
cord-006229-7yoilsho	597	11	,	,	,
cord-006229-7yoilsho	597	12	at	at	IN
cord-006229-7yoilsho	597	13	least	least	JJS
cord-006229-7yoilsho	597	14	four	four	CD
cord-006229-7yoilsho	597	15	have	have	VBP
cord-006229-7yoilsho	597	16	been	be	VBN
cord-006229-7yoilsho	597	17	shown	show	VBN
cord-006229-7yoilsho	597	18	to	to	TO
cord-006229-7yoilsho	597	19	exhibit	exhibit	VB
cord-006229-7yoilsho	597	20	PAR	par	NN
cord-006229-7yoilsho	597	21	-	-	HYPH
cord-006229-7yoilsho	597	22	forming	form	VBG
cord-006229-7yoilsho	597	23	capacity	capacity	NN
cord-006229-7yoilsho	597	24	.	.	.
cord-006229-7yoilsho	598	1	Upon	upon	IN
cord-006229-7yoilsho	598	2	DNA	dna	NN
cord-006229-7yoilsho	598	3	damage	damage	NN
cord-006229-7yoilsho	598	4	PARP1	parp1	NN
cord-006229-7yoilsho	598	5	is	be	VBZ
cord-006229-7yoilsho	598	6	catalytically	catalytically	RB
cord-006229-7yoilsho	598	7	activated	activate	VBN
cord-006229-7yoilsho	598	8	and	and	CC
cord-006229-7yoilsho	598	9	is	be	VBZ
cord-006229-7yoilsho	598	10	thought	think	VBN
cord-006229-7yoilsho	598	11	to	to	TO
cord-006229-7yoilsho	598	12	contribute	contribute	VB
cord-006229-7yoilsho	598	13	to	to	IN
cord-006229-7yoilsho	598	14	the	the	DT
cord-006229-7yoilsho	598	15	bulk	bulk	NN
cord-006229-7yoilsho	598	16	of	of	IN
cord-006229-7yoilsho	598	17	the	the	DT
cord-006229-7yoilsho	598	18	cellular	cellular	JJ
cord-006229-7yoilsho	598	19	PAR	par	NN
cord-006229-7yoilsho	598	20	formation	formation	NN
cord-006229-7yoilsho	598	21	.	.	.
cord-006229-7yoilsho	599	1	PARP	PARP	NNP
cord-006229-7yoilsho	599	2	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	599	3	are	be	VBP
cord-006229-7yoilsho	599	4	currently	currently	RB
cord-006229-7yoilsho	599	5	being	be	VBG
cord-006229-7yoilsho	599	6	tested	test	VBN
cord-006229-7yoilsho	599	7	in	in	IN
cord-006229-7yoilsho	599	8	clinical	clinical	JJ
cord-006229-7yoilsho	599	9	cancer	cancer	NN
cord-006229-7yoilsho	599	10	treatment	treatment	NN
cord-006229-7yoilsho	599	11	,	,	,
cord-006229-7yoilsho	599	12	in	in	IN
cord-006229-7yoilsho	599	13	combination	combination	NN
cord-006229-7yoilsho	599	14	therapy	therapy	NN
cord-006229-7yoilsho	599	15	,	,	,
cord-006229-7yoilsho	599	16	or	or	CC
cord-006229-7yoilsho	599	17	as	as	IN
cord-006229-7yoilsho	599	18	monotherapeutic	monotherapeutic	JJ
cord-006229-7yoilsho	599	19	agents	agent	NNS
cord-006229-7yoilsho	599	20	by	by	IN
cord-006229-7yoilsho	599	21	inducing	induce	VBG
cord-006229-7yoilsho	599	22	synthetic	synthetic	JJ
cord-006229-7yoilsho	599	23	lethality	lethality	NN
cord-006229-7yoilsho	599	24	(	(	-LRB-
cord-006229-7yoilsho	599	25	Mangerich	Mangerich	NNP
cord-006229-7yoilsho	599	26	and	and	CC
cord-006229-7yoilsho	599	27	Bürkle	Bürkle	NNP
cord-006229-7yoilsho	599	28	2011	2011	CD
cord-006229-7yoilsho	599	29	,	,	,
cord-006229-7yoilsho	599	30	Mangerich	Mangerich	NNP
cord-006229-7yoilsho	599	31	and	and	CC
cord-006229-7yoilsho	599	32	Bürkle	Bürkle	NNP
cord-006229-7yoilsho	599	33	2015	2015	CD
cord-006229-7yoilsho	599	34	)	)	-RRB-
cord-006229-7yoilsho	599	35	.	.	.
cord-006229-7yoilsho	600	1	Here	here	RB
cord-006229-7yoilsho	600	2	we	-PRON-	PRP
cord-006229-7yoilsho	600	3	generated	generate	VBD
cord-006229-7yoilsho	600	4	a	a	DT
cord-006229-7yoilsho	600	5	genetic	genetic	JJ
cord-006229-7yoilsho	600	6	knock	knock	NN
cord-006229-7yoilsho	600	7	out	out	IN
cord-006229-7yoilsho	600	8	of	of	IN
cord-006229-7yoilsho	600	9	PARP1	parp1	NN
cord-006229-7yoilsho	600	10	in	in	IN
cord-006229-7yoilsho	600	11	one	one	CD
cord-006229-7yoilsho	600	12	of	of	IN
cord-006229-7yoilsho	600	13	the	the	DT
cord-006229-7yoilsho	600	14	most	most	RBS
cord-006229-7yoilsho	600	15	widely	widely	RB
cord-006229-7yoilsho	600	16	used	use	VBN
cord-006229-7yoilsho	600	17	human	human	JJ
cord-006229-7yoilsho	600	18	cell	cell	NN
cord-006229-7yoilsho	600	19	systems	system	NNS
cord-006229-7yoilsho	600	20	,	,	,
cord-006229-7yoilsho	600	21	i.e.	i.e.	FW
cord-006229-7yoilsho	600	22	HeLa	HeLa	NNP
cord-006229-7yoilsho	600	23	PARP1	PARP1	NNP
cord-006229-7yoilsho	600	24	KO	KO	NNP
cord-006229-7yoilsho	600	25	cells	cell	NNS
cord-006229-7yoilsho	600	26	,	,	,
cord-006229-7yoilsho	600	27	via	via	IN
cord-006229-7yoilsho	600	28	TALEN	TALEN	NNP
cord-006229-7yoilsho	600	29	-	-	HYPH
cord-006229-7yoilsho	600	30	mediated	mediate	VBN
cord-006229-7yoilsho	600	31	gene	gene	NN
cord-006229-7yoilsho	600	32	targeting	targeting	NN
cord-006229-7yoilsho	600	33	and	and	CC
cord-006229-7yoilsho	600	34	characterized	characterize	VBD
cord-006229-7yoilsho	600	35	these	these	DT
cord-006229-7yoilsho	600	36	cells	cell	NNS
cord-006229-7yoilsho	600	37	with	with	IN
cord-006229-7yoilsho	600	38	regards	regard	NNS
cord-006229-7yoilsho	600	39	to	to	IN
cord-006229-7yoilsho	600	40	PARylation	parylation	NN
cord-006229-7yoilsho	600	41	metabolism	metabolism	NN
cord-006229-7yoilsho	600	42	and	and	CC
cord-006229-7yoilsho	600	43	genotoxic	genotoxic	JJ
cord-006229-7yoilsho	600	44	stress	stress	NN
cord-006229-7yoilsho	600	45	response	response	NN
cord-006229-7yoilsho	600	46	.	.	.
cord-006229-7yoilsho	601	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	601	2	,	,	,
cord-006229-7yoilsho	601	3	by	by	IN
cord-006229-7yoilsho	601	4	reconstituting	reconstitute	VBG
cord-006229-7yoilsho	601	5	HeLa	HeLa	NNP
cord-006229-7yoilsho	601	6	PARP1	PARP1	NNP
cord-006229-7yoilsho	601	7	KO	KO	NNP
cord-006229-7yoilsho	601	8	cells	cell	NNS
cord-006229-7yoilsho	601	9	with	with	IN
cord-006229-7yoilsho	601	10	a	a	DT
cord-006229-7yoilsho	601	11	series	series	NN
cord-006229-7yoilsho	601	12	of	of	IN
cord-006229-7yoilsho	601	13	artificial	artificial	JJ
cord-006229-7yoilsho	601	14	and	and	CC
cord-006229-7yoilsho	601	15	natural	natural	JJ
cord-006229-7yoilsho	601	16	PARP1	PARP1	NNP
cord-006229-7yoilsho	601	17	variants	variant	NNS
cord-006229-7yoilsho	601	18	,	,	,
cord-006229-7yoilsho	601	19	we	-PRON-	PRP
cord-006229-7yoilsho	601	20	analyzed	analyze	VBD
cord-006229-7yoilsho	601	21	structure	structure	NN
cord-006229-7yoilsho	601	22	-	-	HYPH
cord-006229-7yoilsho	601	23	function	function	NN
cord-006229-7yoilsho	601	24	relationships	relationship	NNS
cord-006229-7yoilsho	601	25	of	of	IN
cord-006229-7yoilsho	601	26	PARP1	PARP1	NNS
cord-006229-7yoilsho	601	27	in	in	IN
cord-006229-7yoilsho	601	28	a	a	DT
cord-006229-7yoilsho	601	29	cellular	cellular	JJ
cord-006229-7yoilsho	601	30	environment	environment	NN
cord-006229-7yoilsho	601	31	without	without	IN
cord-006229-7yoilsho	601	32	interfering	interfere	VBG
cord-006229-7yoilsho	601	33	with	with	IN
cord-006229-7yoilsho	601	34	endogenously	endogenously	RB
cord-006229-7yoilsho	601	35	expressed	express	VBN
cord-006229-7yoilsho	601	36	WT	WT	NNP
cord-006229-7yoilsho	601	37	-	-	HYPH
cord-006229-7yoilsho	601	38	PARP1	PARP1	NNP
cord-006229-7yoilsho	601	39	.	.	.
cord-006229-7yoilsho	602	1	We	-PRON-	PRP
cord-006229-7yoilsho	602	2	confirmed	confirm	VBD
cord-006229-7yoilsho	602	3	that	that	IN
cord-006229-7yoilsho	602	4	the	the	DT
cord-006229-7yoilsho	602	5	PARP1E988	PARP1E988	NNP
cord-006229-7yoilsho	602	6	K	K	NNP
cord-006229-7yoilsho	602	7	mutant	mutant	JJ
cord-006229-7yoilsho	602	8	exhibits	exhibit	VBZ
cord-006229-7yoilsho	602	9	mono	mono	JJ
cord-006229-7yoilsho	602	10	-	-	HYPH
cord-006229-7yoilsho	602	11	ADP	adp	NN
cord-006229-7yoilsho	602	12	-	-	HYPH
cord-006229-7yoilsho	602	13	ribosylation	ribosylation	NN
cord-006229-7yoilsho	602	14	activity	activity	NN
cord-006229-7yoilsho	602	15	and	and	CC
cord-006229-7yoilsho	602	16	extended	extend	VBD
cord-006229-7yoilsho	602	17	previous	previous	JJ
cord-006229-7yoilsho	602	18	reports	report	NNS
cord-006229-7yoilsho	602	19	by	by	IN
cord-006229-7yoilsho	602	20	demonstrating	demonstrate	VBG
cord-006229-7yoilsho	602	21	that	that	IN
cord-006229-7yoilsho	602	22	the	the	DT
cord-006229-7yoilsho	602	23	PARP1L713F	parp1l713f	NN
cord-006229-7yoilsho	602	24	mutant	mutant	NN
cord-006229-7yoilsho	602	25	is	be	VBZ
cord-006229-7yoilsho	602	26	constitutively	constitutively	RB
cord-006229-7yoilsho	602	27	active	active	JJ
cord-006229-7yoilsho	602	28	in	in	IN
cord-006229-7yoilsho	602	29	a	a	DT
cord-006229-7yoilsho	602	30	cellular	cellular	JJ
cord-006229-7yoilsho	602	31	environment	environment	NN
cord-006229-7yoilsho	602	32	,	,	,
cord-006229-7yoilsho	602	33	leading	lead	VBG
cord-006229-7yoilsho	602	34	to	to	IN
cord-006229-7yoilsho	602	35	high	high	JJ
cord-006229-7yoilsho	602	36	cellular	cellular	JJ
cord-006229-7yoilsho	602	37	PAR	par	NN
cord-006229-7yoilsho	602	38	levels	level	NNS
cord-006229-7yoilsho	602	39	even	even	RB
cord-006229-7yoilsho	602	40	in	in	IN
cord-006229-7yoilsho	602	41	unchallenged	unchallenged	JJ
cord-006229-7yoilsho	602	42	cells	cell	NNS
cord-006229-7yoilsho	602	43	.	.	.
cord-006229-7yoilsho	603	1	Additionally	additionally	RB
cord-006229-7yoilsho	603	2	,	,	,
cord-006229-7yoilsho	603	3	both	both	DT
cord-006229-7yoilsho	603	4	mutants	mutant	NNS
cord-006229-7yoilsho	603	5	exhibited	exhibit	VBD
cord-006229-7yoilsho	603	6	significantly	significantly	RB
cord-006229-7yoilsho	603	7	altered	alter	VBD
cord-006229-7yoilsho	603	8	recruitment	recruitment	NN
cord-006229-7yoilsho	603	9	and	and	CC
cord-006229-7yoilsho	603	10	dissociation	dissociation	NN
cord-006229-7yoilsho	603	11	kinetics	kinetic	NNS
cord-006229-7yoilsho	603	12	at	at	IN
cord-006229-7yoilsho	603	13	sites	site	NNS
cord-006229-7yoilsho	603	14	of	of	IN
cord-006229-7yoilsho	603	15	laser	laser	NN
cord-006229-7yoilsho	603	16	-	-	HYPH
cord-006229-7yoilsho	603	17	induced	induce	VBN
cord-006229-7yoilsho	603	18	DNA	dna	NN
cord-006229-7yoilsho	603	19	-	-	HYPH
cord-006229-7yoilsho	603	20	damage	damage	NN
cord-006229-7yoilsho	603	21	,	,	,
cord-006229-7yoilsho	603	22	which	which	WDT
cord-006229-7yoilsho	603	23	can	can	MD
cord-006229-7yoilsho	603	24	partially	partially	RB
cord-006229-7yoilsho	603	25	be	be	VB
cord-006229-7yoilsho	603	26	attributed	attribute	VBN
cord-006229-7yoilsho	603	27	to	to	IN
cord-006229-7yoilsho	603	28	non	non	JJ
cord-006229-7yoilsho	603	29	-	-	JJ
cord-006229-7yoilsho	603	30	covalent	covalent	JJ
cord-006229-7yoilsho	603	31	PARP1-PAR	PARP1-PAR	NNP
cord-006229-7yoilsho	603	32	interaction	interaction	NN
cord-006229-7yoilsho	603	33	via	via	IN
cord-006229-7yoilsho	603	34	at	at	RB
cord-006229-7yoilsho	603	35	least	least	RBS
cord-006229-7yoilsho	603	36	one	one	CD
cord-006229-7yoilsho	603	37	specific	specific	JJ
cord-006229-7yoilsho	603	38	PAR	par	NN
cord-006229-7yoilsho	603	39	binding	bind	VBG
cord-006229-7yoilsho	603	40	motif	motif	NN
cord-006229-7yoilsho	603	41	located	locate	VBN
cord-006229-7yoilsho	603	42	in	in	IN
cord-006229-7yoilsho	603	43	zinc	zinc	NN
cord-006229-7yoilsho	603	44	finger	finger	NN
cord-006229-7yoilsho	603	45	2	2	CD
cord-006229-7yoilsho	603	46	of	of	IN
cord-006229-7yoilsho	603	47	PARP1	PARP1	NNP
cord-006229-7yoilsho	603	48	.	.	.
cord-006229-7yoilsho	604	1	Expression	expression	NN
cord-006229-7yoilsho	604	2	of	of	IN
cord-006229-7yoilsho	604	3	both	both	DT
cord-006229-7yoilsho	604	4	artificial	artificial	JJ
cord-006229-7yoilsho	604	5	mutants	mutant	NNS
cord-006229-7yoilsho	604	6	led	lead	VBD
cord-006229-7yoilsho	604	7	to	to	IN
cord-006229-7yoilsho	604	8	distinct	distinct	JJ
cord-006229-7yoilsho	604	9	cellular	cellular	JJ
cord-006229-7yoilsho	604	10	consequences	consequence	NNS
cord-006229-7yoilsho	604	11	,	,	,
cord-006229-7yoilsho	604	12	caused	cause	VBN
cord-006229-7yoilsho	604	13	by	by	IN
cord-006229-7yoilsho	604	14	the	the	DT
cord-006229-7yoilsho	604	15	altered	alter	VBN
cord-006229-7yoilsho	604	16	cellular	cellular	JJ
cord-006229-7yoilsho	604	17	biochemistry	biochemistry	NN
cord-006229-7yoilsho	604	18	.	.	.
cord-006229-7yoilsho	605	1	While	while	IN
cord-006229-7yoilsho	605	2	the	the	DT
cord-006229-7yoilsho	605	3	expression	expression	NN
cord-006229-7yoilsho	605	4	of	of	IN
cord-006229-7yoilsho	605	5	PARP1L713F	parp1l713f	NN
cord-006229-7yoilsho	605	6	itself	-PRON-	PRP
cord-006229-7yoilsho	605	7	triggered	trigger	VBD
cord-006229-7yoilsho	605	8	apoptosis	apoptosis	NN
cord-006229-7yoilsho	605	9	,	,	,
cord-006229-7yoilsho	605	10	PARP1E988	PARP1E988	NNP
cord-006229-7yoilsho	605	11	K	K	NNP
cord-006229-7yoilsho	605	12	expression	expression	NN
cord-006229-7yoilsho	605	13	led	lead	VBD
cord-006229-7yoilsho	605	14	to	to	IN
cord-006229-7yoilsho	605	15	a	a	DT
cord-006229-7yoilsho	605	16	strong	strong	JJ
cord-006229-7yoilsho	605	17	G2-arrest	g2-arrest	NN
cord-006229-7yoilsho	605	18	during	during	IN
cord-006229-7yoilsho	605	19	cell	cell	NN
cord-006229-7yoilsho	605	20	cycle	cycle	NN
cord-006229-7yoilsho	605	21	and	and	CC
cord-006229-7yoilsho	605	22	sensitized	sensitize	VBN
cord-006229-7yoilsho	605	23	cells	cell	NNS
cord-006229-7yoilsho	605	24	to	to	IN
cord-006229-7yoilsho	605	25	camptothecin	camptothecin	NNS
cord-006229-7yoilsho	605	26	treatment	treatment	NN
cord-006229-7yoilsho	605	27	.	.	.
cord-006229-7yoilsho	606	1	Interestingly	interestingly	RB
cord-006229-7yoilsho	606	2	,	,	,
cord-006229-7yoilsho	606	3	pharmacological	pharmacological	JJ
cord-006229-7yoilsho	606	4	PARP	PARP	NNP
cord-006229-7yoilsho	606	5	inhibition	inhibition	NN
cord-006229-7yoilsho	606	6	with	with	IN
cord-006229-7yoilsho	606	7	ABT888	ABT888	NNP
cord-006229-7yoilsho	606	8	mitigated	mitigate	VBN
cord-006229-7yoilsho	606	9	effects	effect	NNS
cord-006229-7yoilsho	606	10	of	of	IN
cord-006229-7yoilsho	606	11	the	the	DT
cord-006229-7yoilsho	606	12	E988	E988	NNP
cord-006229-7yoilsho	606	13	K	K	NNP
cord-006229-7yoilsho	606	14	mutant	mutant	NN
cord-006229-7yoilsho	606	15	,	,	,
cord-006229-7yoilsho	606	16	suggesting	suggest	VBG
cord-006229-7yoilsho	606	17	distinct	distinct	JJ
cord-006229-7yoilsho	606	18	functions	function	NNS
cord-006229-7yoilsho	606	19	of	of	IN
cord-006229-7yoilsho	606	20	mono	mono	JJ
cord-006229-7yoilsho	606	21	-	-	HYPH
cord-006229-7yoilsho	606	22	ADP	adp	NN
cord-006229-7yoilsho	606	23	-	-	HYPH
cord-006229-7yoilsho	606	24	ribosylation	ribosylation	NN
cord-006229-7yoilsho	606	25	.	.	.
cord-006229-7yoilsho	607	1	Finally	finally	RB
cord-006229-7yoilsho	607	2	,	,	,
cord-006229-7yoilsho	607	3	by	by	IN
cord-006229-7yoilsho	607	4	reconstituting	reconstitute	VBG
cord-006229-7yoilsho	607	5	PARP1	PARP1	NNP
cord-006229-7yoilsho	607	6	KO	KO	NNP
cord-006229-7yoilsho	607	7	cells	cell	NNS
cord-006229-7yoilsho	607	8	with	with	IN
cord-006229-7yoilsho	607	9	a	a	DT
cord-006229-7yoilsho	607	10	natural	natural	JJ
cord-006229-7yoilsho	607	11	cancer	cancer	NN
cord-006229-7yoilsho	607	12	-	-	HYPH
cord-006229-7yoilsho	607	13	associated	associate	VBN
cord-006229-7yoilsho	607	14	PARP1	parp1	IN
cord-006229-7yoilsho	607	15	SNP	SNP	NNP
cord-006229-7yoilsho	607	16	variant	variant	NN
cord-006229-7yoilsho	607	17	(	(	-LRB-
cord-006229-7yoilsho	607	18	V762A	V762A	NNP
cord-006229-7yoilsho	607	19	)	)	-RRB-
cord-006229-7yoilsho	607	20	,	,	,
cord-006229-7yoilsho	607	21	as	as	RB
cord-006229-7yoilsho	607	22	well	well	RB
cord-006229-7yoilsho	607	23	as	as	IN
cord-006229-7yoilsho	607	24	a	a	DT
cord-006229-7yoilsho	607	25	newly	newly	RB
cord-006229-7yoilsho	607	26	identified	identify	VBN
cord-006229-7yoilsho	607	27	PARP1	parp1	IN
cord-006229-7yoilsho	607	28	mutant	mutant	JJ
cord-006229-7yoilsho	607	29	present	present	NN
cord-006229-7yoilsho	607	30	in	in	IN
cord-006229-7yoilsho	607	31	a	a	DT
cord-006229-7yoilsho	607	32	patient	patient	NN
cord-006229-7yoilsho	607	33	of	of	IN
cord-006229-7yoilsho	607	34	pediatric	pediatric	JJ
cord-006229-7yoilsho	607	35	colorectal	colorectal	JJ
cord-006229-7yoilsho	607	36	carcinoma	carcinoma	NN
cord-006229-7yoilsho	607	37	(	(	-LRB-
cord-006229-7yoilsho	607	38	F304L	F304L	NNP
cord-006229-7yoilsho	607	39	-	-	HYPH
cord-006229-7yoilsho	607	40	V762A	V762A	NNP
cord-006229-7yoilsho	607	41	)	)	-RRB-
cord-006229-7yoilsho	607	42	,	,	,
cord-006229-7yoilsho	607	43	we	-PRON-	PRP
cord-006229-7yoilsho	607	44	demonstrate	demonstrate	VBP
cord-006229-7yoilsho	607	45	,	,	,
cord-006229-7yoilsho	607	46	that	that	IN
cord-006229-7yoilsho	607	47	these	these	DT
cord-006229-7yoilsho	607	48	variants	variant	NNS
cord-006229-7yoilsho	607	49	exhibit	exhibit	VBP
cord-006229-7yoilsho	607	50	altered	alter	VBN
cord-006229-7yoilsho	607	51	biochemical	biochemical	JJ
cord-006229-7yoilsho	607	52	and	and	CC
cord-006229-7yoilsho	607	53	cellular	cellular	JJ
cord-006229-7yoilsho	607	54	properties	property	NNS
cord-006229-7yoilsho	607	55	,	,	,
cord-006229-7yoilsho	607	56	potentially	potentially	RB
cord-006229-7yoilsho	607	57	supporting	support	VBG
cord-006229-7yoilsho	607	58	carcinogenesis	carcinogenesis	NN
cord-006229-7yoilsho	607	59	.	.	.
cord-006229-7yoilsho	608	1	Together	together	RB
cord-006229-7yoilsho	608	2	,	,	,
cord-006229-7yoilsho	608	3	this	this	DT
cord-006229-7yoilsho	608	4	study	study	NN
cord-006229-7yoilsho	608	5	establishes	establish	VBZ
cord-006229-7yoilsho	608	6	a	a	DT
cord-006229-7yoilsho	608	7	novel	novel	JJ
cord-006229-7yoilsho	608	8	model	model	NN
cord-006229-7yoilsho	608	9	to	to	TO
cord-006229-7yoilsho	608	10	study	study	VB
cord-006229-7yoilsho	608	11	PARP1-dependent	PARP1-dependent	NNP
cord-006229-7yoilsho	608	12	PARylation	parylation	NN
cord-006229-7yoilsho	608	13	during	during	IN
cord-006229-7yoilsho	608	14	genotoxic	genotoxic	JJ
cord-006229-7yoilsho	608	15	stress	stress	NN
cord-006229-7yoilsho	608	16	response	response	NN
cord-006229-7yoilsho	608	17	and	and	CC
cord-006229-7yoilsho	608	18	reveals	reveal	VBZ
cord-006229-7yoilsho	608	19	new	new	JJ
cord-006229-7yoilsho	608	20	insight	insight	NN
cord-006229-7yoilsho	608	21	into	into	IN
cord-006229-7yoilsho	608	22	the	the	DT
cord-006229-7yoilsho	608	23	structure	structure	NN
cord-006229-7yoilsho	608	24	-	-	HYPH
cord-006229-7yoilsho	608	25	function	function	NN
cord-006229-7yoilsho	608	26	relationships	relationship	NNS
cord-006229-7yoilsho	608	27	of	of	IN
cord-006229-7yoilsho	608	28	artificial	artificial	JJ
cord-006229-7yoilsho	608	29	as	as	RB
cord-006229-7yoilsho	608	30	well	well	RB
cord-006229-7yoilsho	608	31	as	as	IN
cord-006229-7yoilsho	608	32	natural	natural	JJ
cord-006229-7yoilsho	608	33	PARP1	PARP1	NNP
cord-006229-7yoilsho	608	34	variants	variant	NNS
cord-006229-7yoilsho	608	35	in	in	IN
cord-006229-7yoilsho	608	36	a	a	DT
cord-006229-7yoilsho	608	37	cellular	cellular	JJ
cord-006229-7yoilsho	608	38	environment	environment	NN
cord-006229-7yoilsho	608	39	,	,	,
cord-006229-7yoilsho	608	40	with	with	IN
cord-006229-7yoilsho	608	41	implications	implication	NNS
cord-006229-7yoilsho	608	42	for	for	IN
cord-006229-7yoilsho	608	43	PARP	PARP	NNP
cord-006229-7yoilsho	608	44	research	research	NN
cord-006229-7yoilsho	608	45	in	in	IN
cord-006229-7yoilsho	608	46	general	general	JJ
cord-006229-7yoilsho	608	47	.	.	.
cord-006229-7yoilsho	609	1	Mangerich	Mangerich	NNP
cord-006229-7yoilsho	609	2	,	,	,
cord-006229-7yoilsho	609	3	A.	a.	NN
cord-006229-7yoilsho	609	4	and	and	CC
cord-006229-7yoilsho	609	5	A.	A.	NNP
cord-006229-7yoilsho	609	6	Bürkle	Bürkle	NNP
cord-006229-7yoilsho	609	7	(	(	-LRB-
cord-006229-7yoilsho	609	8	2011	2011	CD
cord-006229-7yoilsho	609	9	)	)	-RRB-
cord-006229-7yoilsho	609	10	.	.	.
cord-006229-7yoilsho	610	1	"	"	``
cord-006229-7yoilsho	610	2	How	how	WRB
cord-006229-7yoilsho	610	3	to	to	TO
cord-006229-7yoilsho	610	4	kill	kill	VB
cord-006229-7yoilsho	610	5	tumor	tumor	NN
cord-006229-7yoilsho	610	6	cells	cell	NNS
cord-006229-7yoilsho	610	7	with	with	IN
cord-006229-7yoilsho	610	8	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	610	9	of	of	IN
cord-006229-7yoilsho	610	10	poly(ADPribosyl)ation	poly(adpribosyl)ation	CD
cord-006229-7yoilsho	610	11	.	.	.
cord-006229-7yoilsho	610	12	"	"	''
cord-006229-7yoilsho	611	1	Int	Int	NNP
cord-006229-7yoilsho	611	2	J	J	NNP
cord-006229-7yoilsho	611	3	Cancer128	Cancer128	NNP
cord-006229-7yoilsho	612	1	(	(	-LRB-
cord-006229-7yoilsho	612	2	2	2	LS
cord-006229-7yoilsho	612	3	)	)	-RRB-
cord-006229-7yoilsho	612	4	:	:	:
cord-006229-7yoilsho	613	1	251	251	CD
cord-006229-7yoilsho	613	2	-	-	SYM
cord-006229-7yoilsho	613	3	265	265	CD
cord-006229-7yoilsho	613	4	.	.	.
cord-006229-7yoilsho	614	1	Mangerich	Mangerich	NNP
cord-006229-7yoilsho	614	2	,	,	,
cord-006229-7yoilsho	614	3	A.	a.	NN
cord-006229-7yoilsho	614	4	and	and	CC
cord-006229-7yoilsho	614	5	A.	A.	NNP
cord-006229-7yoilsho	614	6	Bürkle	Bürkle	NNP
cord-006229-7yoilsho	614	7	(	(	-LRB-
cord-006229-7yoilsho	614	8	2015	2015	CD
cord-006229-7yoilsho	614	9	)	)	-RRB-
cord-006229-7yoilsho	614	10	.	.	.
cord-006229-7yoilsho	615	1	Multitasking	multitaske	VBG
cord-006229-7yoilsho	615	2	Roles	Roles	NNP
cord-006229-7yoilsho	615	3	for	for	IN
cord-006229-7yoilsho	615	4	Poly	Poly	NNP
cord-006229-7yoilsho	615	5	(	(	-LRB-
cord-006229-7yoilsho	615	6	ADP	ADP	NNP
cord-006229-7yoilsho	615	7	-	-	HYPH
cord-006229-7yoilsho	615	8	ribosyl	ribosyl	NN
cord-006229-7yoilsho	615	9	)	)	-RRB-
cord-006229-7yoilsho	615	10	ation	ation	NN
cord-006229-7yoilsho	615	11	in	in	IN
cord-006229-7yoilsho	615	12	Aging	Aging	NNP
cord-006229-7yoilsho	615	13	and	and	CC
cord-006229-7yoilsho	615	14	Longevity	Longevity	NNP
cord-006229-7yoilsho	615	15	.	.	.
cord-006229-7yoilsho	616	1	PARP	PARP	NNP
cord-006229-7yoilsho	616	2	Inhibitors	Inhibitors	NNP
cord-006229-7yoilsho	616	3	for	for	IN
cord-006229-7yoilsho	616	4	Cancer	Cancer	NNP
cord-006229-7yoilsho	616	5	Therapy	Therapy	NNP
cord-006229-7yoilsho	616	6	,	,	,
cord-006229-7yoilsho	616	7	Springer	Springer	NNP
cord-006229-7yoilsho	616	8	:	:	:
cord-006229-7yoilsho	616	9	125	125	CD
cord-006229-7yoilsho	616	10	-	-	SYM
cord-006229-7yoilsho	616	11	179	179	CD
cord-006229-7yoilsho	616	12	.	.	.
cord-006229-7yoilsho	617	1	Leukemic	leukemic	JJ
cord-006229-7yoilsho	617	2	cells	cell	NNS
cord-006229-7yoilsho	617	3	frequently	frequently	RB
cord-006229-7yoilsho	617	4	overexpress	overexpress	VBP
cord-006229-7yoilsho	617	5	the	the	DT
cord-006229-7yoilsho	617	6	transcription	transcription	NN
cord-006229-7yoilsho	617	7	factor	factor	NN
cord-006229-7yoilsho	617	8	Wilms	Wilms	NNP
cord-006229-7yoilsho	617	9	Tumor	Tumor	NNP
cord-006229-7yoilsho	617	10	1	1	CD
cord-006229-7yoilsho	617	11	(	(	-LRB-
cord-006229-7yoilsho	617	12	WT1	WT1	NNP
cord-006229-7yoilsho	617	13	)	)	-RRB-
cord-006229-7yoilsho	617	14	and	and	CC
cord-006229-7yoilsho	617	15	the	the	DT
cord-006229-7yoilsho	617	16	persistence	persistence	NN
cord-006229-7yoilsho	617	17	of	of	IN
cord-006229-7yoilsho	617	18	WT1	wt1	JJ
cord-006229-7yoilsho	617	19	expression	expression	NN
cord-006229-7yoilsho	617	20	after	after	IN
cord-006229-7yoilsho	617	21	chemotherapy	chemotherapy	NN
cord-006229-7yoilsho	617	22	indicates	indicate	VBZ
cord-006229-7yoilsho	617	23	remaining	remain	VBG
cord-006229-7yoilsho	617	24	leukemic	leukemic	JJ
cord-006229-7yoilsho	617	25	stem	stem	NN
cord-006229-7yoilsho	617	26	cells	cell	NNS
cord-006229-7yoilsho	617	27	.	.	.
cord-006229-7yoilsho	618	1	Hydroxyurea	Hydroxyurea	NNP
cord-006229-7yoilsho	618	2	induces	induce	VBZ
cord-006229-7yoilsho	618	3	replicative	replicative	JJ
cord-006229-7yoilsho	618	4	stress	stress	NN
cord-006229-7yoilsho	618	5	by	by	IN
cord-006229-7yoilsho	618	6	its	-PRON-	PRP$
cord-006229-7yoilsho	618	7	ability	ability	NN
cord-006229-7yoilsho	618	8	to	to	TO
cord-006229-7yoilsho	618	9	inhibit	inhibit	VB
cord-006229-7yoilsho	618	10	ribonucleotide	ribonucleotide	NN
cord-006229-7yoilsho	618	11	reductase	reductase	NN
cord-006229-7yoilsho	618	12	,	,	,
cord-006229-7yoilsho	618	13	an	an	DT
cord-006229-7yoilsho	618	14	enzyme	enzyme	NN
cord-006229-7yoilsho	618	15	that	that	WDT
cord-006229-7yoilsho	618	16	catalyzes	catalyze	VBZ
cord-006229-7yoilsho	618	17	the	the	DT
cord-006229-7yoilsho	618	18	synthesis	synthesis	NN
cord-006229-7yoilsho	618	19	of	of	IN
cord-006229-7yoilsho	618	20	dNTPs	dntps	CD
cord-006229-7yoilsho	618	21	from	from	IN
cord-006229-7yoilsho	618	22	NTPs	ntp	NNS
cord-006229-7yoilsho	618	23	.	.	.
cord-006229-7yoilsho	619	1	We	-PRON-	PRP
cord-006229-7yoilsho	619	2	demonstrate	demonstrate	VBP
cord-006229-7yoilsho	619	3	that	that	IN
cord-006229-7yoilsho	619	4	the	the	DT
cord-006229-7yoilsho	619	5	expression	expression	NN
cord-006229-7yoilsho	619	6	levels	level	NNS
cord-006229-7yoilsho	619	7	of	of	IN
cord-006229-7yoilsho	619	8	WT1	WT1	NNP
cord-006229-7yoilsho	619	9	determines	determine	VBZ
cord-006229-7yoilsho	619	10	the	the	DT
cord-006229-7yoilsho	619	11	extent	extent	NN
cord-006229-7yoilsho	619	12	of	of	IN
cord-006229-7yoilsho	619	13	DNA	dna	NN
cord-006229-7yoilsho	619	14	damage	damage	NN
cord-006229-7yoilsho	619	15	and	and	CC
cord-006229-7yoilsho	619	16	apoptosis	apoptosis	NN
cord-006229-7yoilsho	619	17	in	in	IN
cord-006229-7yoilsho	619	18	a	a	DT
cord-006229-7yoilsho	619	19	panel	panel	NN
cord-006229-7yoilsho	619	20	of	of	IN
cord-006229-7yoilsho	619	21	leukemic	leukemic	JJ
cord-006229-7yoilsho	619	22	cells	cell	NNS
cord-006229-7yoilsho	619	23	treated	treat	VBN
cord-006229-7yoilsho	619	24	with	with	IN
cord-006229-7yoilsho	619	25	hydroxyurea	hydroxyurea	NNP
cord-006229-7yoilsho	619	26	.	.	.
cord-006229-7yoilsho	620	1	Accordingly	accordingly	RB
cord-006229-7yoilsho	620	2	,	,	,
cord-006229-7yoilsho	620	3	inhibiting	inhibit	VBG
cord-006229-7yoilsho	620	4	apoptosis	apoptosis	NN
cord-006229-7yoilsho	620	5	through	through	IN
cord-006229-7yoilsho	620	6	chemical	chemical	JJ
cord-006229-7yoilsho	620	7	inhibition	inhibition	NN
cord-006229-7yoilsho	620	8	of	of	IN
cord-006229-7yoilsho	620	9	caspases	caspase	NNS
cord-006229-7yoilsho	620	10	or	or	CC
cord-006229-7yoilsho	620	11	by	by	IN
cord-006229-7yoilsho	620	12	overexpression	overexpression	NN
cord-006229-7yoilsho	620	13	of	of	IN
cord-006229-7yoilsho	620	14	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	620	15	anti	anti	JJ
cord-006229-7yoilsho	620	16	-	-	JJ
cord-006229-7yoilsho	620	17	apoptotic	apoptotic	JJ
cord-006229-7yoilsho	620	18	BCL	BCL	NNP
cord-006229-7yoilsho	620	19	proteins	protein	NNS
cord-006229-7yoilsho	620	20	prevents	prevent	VBZ
cord-006229-7yoilsho	620	21	the	the	DT
cord-006229-7yoilsho	620	22	hydroxyurea	hydroxyurea	NN
cord-006229-7yoilsho	620	23	-	-	HYPH
cord-006229-7yoilsho	620	24	induced	induce	VBN
cord-006229-7yoilsho	620	25	depletion	depletion	NN
cord-006229-7yoilsho	620	26	of	of	IN
cord-006229-7yoilsho	620	27	WT1	wt1	NN
cord-006229-7yoilsho	620	28	and	and	CC
cord-006229-7yoilsho	620	29	cell	cell	NN
cord-006229-7yoilsho	620	30	death	death	NN
cord-006229-7yoilsho	620	31	.	.	.
cord-006229-7yoilsho	621	1	In	in	IN
cord-006229-7yoilsho	621	2	addition	addition	NN
cord-006229-7yoilsho	621	3	,	,	,
cord-006229-7yoilsho	621	4	we	-PRON-	PRP
cord-006229-7yoilsho	621	5	show	show	VBP
cord-006229-7yoilsho	621	6	that	that	IN
cord-006229-7yoilsho	621	7	an	an	DT
cord-006229-7yoilsho	621	8	RNA	RNA	NNP
cord-006229-7yoilsho	621	9	interference	interference	NN
cord-006229-7yoilsho	621	10	-	-	HYPH
cord-006229-7yoilsho	621	11	mediated	mediate	VBN
cord-006229-7yoilsho	621	12	elimination	elimination	NN
cord-006229-7yoilsho	621	13	of	of	IN
cord-006229-7yoilsho	621	14	WT1	WT1	NNP
cord-006229-7yoilsho	621	15	sensitizes	sensitize	VBZ
cord-006229-7yoilsho	621	16	leukemic	leukemic	JJ
cord-006229-7yoilsho	621	17	cells	cell	NNS
cord-006229-7yoilsho	621	18	to	to	IN
cord-006229-7yoilsho	621	19	the	the	DT
cord-006229-7yoilsho	621	20	pro	pro	JJ
cord-006229-7yoilsho	621	21	-	-	JJ
cord-006229-7yoilsho	621	22	apoptotic	apoptotic	JJ
cord-006229-7yoilsho	621	23	and	and	CC
cord-006229-7yoilsho	621	24	DNA	dna	VB
cord-006229-7yoilsho	621	25	damaging	damaging	JJ
cord-006229-7yoilsho	621	26	effects	effect	NNS
cord-006229-7yoilsho	621	27	of	of	IN
cord-006229-7yoilsho	621	28	hydroxyurea	hydroxyurea	NN
cord-006229-7yoilsho	621	29	.	.	.
cord-006229-7yoilsho	622	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	622	2	,	,	,
cord-006229-7yoilsho	622	3	such	such	PDT
cord-006229-7yoilsho	622	4	a	a	DT
cord-006229-7yoilsho	622	5	loss	loss	NN
cord-006229-7yoilsho	622	6	of	of	IN
cord-006229-7yoilsho	622	7	WT1	wt1	WP
cord-006229-7yoilsho	622	8	suppresses	suppress	VBZ
cord-006229-7yoilsho	622	9	hydroxyurea	hydroxyurea	NN
cord-006229-7yoilsho	622	10	-	-	HYPH
cord-006229-7yoilsho	622	11	induced	induce	VBN
cord-006229-7yoilsho	622	12	erythroid	erythroid	JJ
cord-006229-7yoilsho	622	13	differentiation	differentiation	NN
cord-006229-7yoilsho	622	14	.	.	.
cord-006229-7yoilsho	623	1	Pharmacological	pharmacological	JJ
cord-006229-7yoilsho	623	2	approaches	approach	NNS
cord-006229-7yoilsho	623	3	that	that	WDT
cord-006229-7yoilsho	623	4	diminish	diminish	VBP
cord-006229-7yoilsho	623	5	WT1	wt1	WDT
cord-006229-7yoilsho	623	6	also	also	RB
cord-006229-7yoilsho	623	7	sensitize	sensitize	VB
cord-006229-7yoilsho	623	8	cells	cell	NNS
cord-006229-7yoilsho	623	9	to	to	IN
cord-006229-7yoilsho	623	10	hydroxyurea	hydroxyurea	NNP
cord-006229-7yoilsho	623	11	.	.	.
cord-006229-7yoilsho	624	1	These	these	DT
cord-006229-7yoilsho	624	2	include	include	VBP
cord-006229-7yoilsho	624	3	the	the	DT
cord-006229-7yoilsho	624	4	tyrosine	tyrosine	NN
cord-006229-7yoilsho	624	5	kinase	kinase	NN
cord-006229-7yoilsho	624	6	inhibitor	inhibitor	NN
cord-006229-7yoilsho	624	7	(	(	-LRB-
cord-006229-7yoilsho	624	8	TKi	TKi	NNP
cord-006229-7yoilsho	624	9	)	)	-RRB-
cord-006229-7yoilsho	624	10	imatinib	imatinib	JJ
cord-006229-7yoilsho	624	11	or	or	CC
cord-006229-7yoilsho	624	12	epigenetic	epigenetic	JJ
cord-006229-7yoilsho	624	13	modifiers	modifier	NNS
cord-006229-7yoilsho	624	14	belonging	belong	VBG
cord-006229-7yoilsho	624	15	to	to	IN
cord-006229-7yoilsho	624	16	the	the	DT
cord-006229-7yoilsho	624	17	histone	histone	NN
cord-006229-7yoilsho	624	18	deacetylase	deacetylase	NN
cord-006229-7yoilsho	624	19	inhibitor	inhibitor	NN
cord-006229-7yoilsho	624	20	(	(	-LRB-
cord-006229-7yoilsho	624	21	HDACi	HDACi	NNS
cord-006229-7yoilsho	624	22	)	)	-RRB-
cord-006229-7yoilsho	624	23	group	group	NN
cord-006229-7yoilsho	624	24	.	.	.
cord-006229-7yoilsho	625	1	Thus	thus	RB
cord-006229-7yoilsho	625	2	,	,	,
cord-006229-7yoilsho	625	3	an	an	DT
cord-006229-7yoilsho	625	4	inhibition	inhibition	NN
cord-006229-7yoilsho	625	5	of	of	IN
cord-006229-7yoilsho	625	6	WT1	wt1	WP
cord-006229-7yoilsho	625	7	is	be	VBZ
cord-006229-7yoilsho	625	8	therapeutically	therapeutically	RB
cord-006229-7yoilsho	625	9	exploitable	exploitable	JJ
cord-006229-7yoilsho	625	10	for	for	IN
cord-006229-7yoilsho	625	11	a	a	DT
cord-006229-7yoilsho	625	12	targeting	target	VBG
cord-006229-7yoilsho	625	13	approach	approach	NN
cord-006229-7yoilsho	625	14	against	against	IN
cord-006229-7yoilsho	625	15	leukemic	leukemic	JJ
cord-006229-7yoilsho	625	16	cells	cell	NNS
cord-006229-7yoilsho	625	17	undergoing	undergo	VBG
cord-006229-7yoilsho	625	18	replicative	replicative	JJ
cord-006229-7yoilsho	625	19	stress	stress	NN
cord-006229-7yoilsho	625	20	.	.	.
cord-006229-7yoilsho	626	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	626	2	novel	novel	JJ
cord-006229-7yoilsho	626	3	findings	finding	NNS
cord-006229-7yoilsho	626	4	reveal	reveal	VBP
cord-006229-7yoilsho	626	5	that	that	IN
cord-006229-7yoilsho	626	6	WT1	wt1	WP
cord-006229-7yoilsho	626	7	is	be	VBZ
cord-006229-7yoilsho	626	8	a	a	DT
cord-006229-7yoilsho	626	9	novel	novel	JJ
cord-006229-7yoilsho	626	10	biological	biological	JJ
cord-006229-7yoilsho	626	11	target	target	NN
cord-006229-7yoilsho	626	12	of	of	IN
cord-006229-7yoilsho	626	13	hydroxyurea	hydroxyurea	NNP
cord-006229-7yoilsho	626	14	and	and	CC
cord-006229-7yoilsho	626	15	they	-PRON-	PRP
cord-006229-7yoilsho	626	16	suggest	suggest	VBP
cord-006229-7yoilsho	626	17	that	that	IN
cord-006229-7yoilsho	626	18	WT1	wt1	WP
cord-006229-7yoilsho	626	19	has	have	VBZ
cord-006229-7yoilsho	626	20	a	a	DT
cord-006229-7yoilsho	626	21	previously	previously	RB
cord-006229-7yoilsho	626	22	unrecognized	unrecognized	JJ
cord-006229-7yoilsho	626	23	ability	ability	NN
cord-006229-7yoilsho	626	24	to	to	TO
cord-006229-7yoilsho	626	25	prevent	prevent	VB
cord-006229-7yoilsho	626	26	DNA	dna	NN
cord-006229-7yoilsho	626	27	damage	damage	NN
cord-006229-7yoilsho	626	28	when	when	WRB
cord-006229-7yoilsho	626	29	replication	replication	NN
cord-006229-7yoilsho	626	30	forks	fork	NNS
cord-006229-7yoilsho	626	31	halt	halt	VBP
cord-006229-7yoilsho	626	32	and	and	CC
cord-006229-7yoilsho	626	33	eventually	eventually	RB
cord-006229-7yoilsho	626	34	collapse	collapse	VBP
cord-006229-7yoilsho	626	35	.	.	.
cord-006229-7yoilsho	627	1	FRET	FRET	NNP
cord-006229-7yoilsho	628	1	(	(	-LRB-
cord-006229-7yoilsho	628	2	fluorescence	fluorescence	NN
cord-006229-7yoilsho	628	3	resonance	resonance	NN
cord-006229-7yoilsho	628	4	energy	energy	NN
cord-006229-7yoilsho	628	5	transfer)-based	transfer)-based	NNP
cord-006229-7yoilsho	628	6	cell	cell	NN
cord-006229-7yoilsho	628	7	assays	assay	NNS
cord-006229-7yoilsho	628	8	were	be	VBD
cord-006229-7yoilsho	628	9	developed	develop	VBN
cord-006229-7yoilsho	628	10	to	to	TO
cord-006229-7yoilsho	628	11	directly	directly	RB
cord-006229-7yoilsho	628	12	monitor	monitor	VB
cord-006229-7yoilsho	628	13	receptor	receptor	NN
cord-006229-7yoilsho	628	14	activation	activation	NN
cord-006229-7yoilsho	628	15	and	and	CC
cord-006229-7yoilsho	628	16	receptor	receptor	NN
cord-006229-7yoilsho	628	17	-	-	HYPH
cord-006229-7yoilsho	628	18	stimulated	stimulate	VBN
cord-006229-7yoilsho	628	19	cAMP	camp	NN
cord-006229-7yoilsho	628	20	response	response	NN
cord-006229-7yoilsho	628	21	.	.	.
cord-006229-7yoilsho	629	1	Mutant	mutant	JJ
cord-006229-7yoilsho	629	2	ß	ß	NN
cord-006229-7yoilsho	629	3	1	1	CD
cord-006229-7yoilsho	629	4	AR	AR	NNP
cord-006229-7yoilsho	629	5	were	be	VBD
cord-006229-7yoilsho	629	6	generated	generate	VBN
cord-006229-7yoilsho	629	7	by	by	IN
cord-006229-7yoilsho	629	8	insertion	insertion	NN
cord-006229-7yoilsho	629	9	of	of	IN
cord-006229-7yoilsho	629	10	cyan	cyan	NN
cord-006229-7yoilsho	629	11	and	and	CC
cord-006229-7yoilsho	629	12	yellow	yellow	JJ
cord-006229-7yoilsho	629	13	fluorescent	fluorescent	NN
cord-006229-7yoilsho	629	14	proteins	protein	NNS
cord-006229-7yoilsho	629	15	(	(	-LRB-
cord-006229-7yoilsho	629	16	CFP	CFP	NNP
cord-006229-7yoilsho	629	17	and	and	CC
cord-006229-7yoilsho	629	18	YFP	YFP	NNP
cord-006229-7yoilsho	629	19	)	)	-RRB-
cord-006229-7yoilsho	629	20	into	into	IN
cord-006229-7yoilsho	629	21	the	the	DT
cord-006229-7yoilsho	629	22	third	third	JJ
cord-006229-7yoilsho	629	23	intracellular	intracellular	JJ
cord-006229-7yoilsho	629	24	loop	loop	NN
cord-006229-7yoilsho	629	25	and	and	CC
cord-006229-7yoilsho	629	26	the	the	DT
cord-006229-7yoilsho	629	27	C	c	NN
cord-006229-7yoilsho	629	28	-	-	HYPH
cord-006229-7yoilsho	629	29	terminus	terminus	NN
cord-006229-7yoilsho	629	30	,	,	,
cord-006229-7yoilsho	629	31	respectively	respectively	RB
cord-006229-7yoilsho	629	32	(	(	-LRB-
cord-006229-7yoilsho	629	33	Bornholz	Bornholz	NNP
cord-006229-7yoilsho	629	34	et	et	FW
cord-006229-7yoilsho	629	35	al	al	NNP
cord-006229-7yoilsho	629	36	.	.	NNP
cord-006229-7yoilsho	629	37	,	,	,
cord-006229-7yoilsho	630	1	Cardiovasc	Cardiovasc	NNP
cord-006229-7yoilsho	630	2	Res	Res	NNP
cord-006229-7yoilsho	630	3	97:472	97:472	CD
cord-006229-7yoilsho	630	4	,	,	,
cord-006229-7yoilsho	630	5	2013	2013	CD
cord-006229-7yoilsho	630	6	)	)	-RRB-
cord-006229-7yoilsho	630	7	and	and	CC
cord-006229-7yoilsho	630	8	stably	stably	RB
cord-006229-7yoilsho	630	9	transfected	transfecte	VBN
cord-006229-7yoilsho	630	10	to	to	IN
cord-006229-7yoilsho	630	11	HEK	HEK	NNP
cord-006229-7yoilsho	630	12	293	293	CD
cord-006229-7yoilsho	630	13	cells	cell	NNS
cord-006229-7yoilsho	630	14	(	(	-LRB-
cord-006229-7yoilsho	630	15	Hekß	Hekß	NNP
cord-006229-7yoilsho	630	16	1	1	CD
cord-006229-7yoilsho	630	17	-Fret	-Fret	NNP
cord-006229-7yoilsho	630	18	)	)	-RRB-
cord-006229-7yoilsho	630	19	.	.	.
cord-006229-7yoilsho	631	1	To	to	TO
cord-006229-7yoilsho	631	2	monitor	monitor	VB
cord-006229-7yoilsho	631	3	the	the	DT
cord-006229-7yoilsho	631	4	cAMP	camp	NN
cord-006229-7yoilsho	631	5	response	response	NN
cord-006229-7yoilsho	631	6	the	the	DT
cord-006229-7yoilsho	631	7	Epac1-based	Epac1-based	NNP
cord-006229-7yoilsho	631	8	FRET	FRET	NNP
cord-006229-7yoilsho	631	9	sensor	sensor	NN
cord-006229-7yoilsho	631	10	of	of	IN
cord-006229-7yoilsho	631	11	cAMP	camp	NN
cord-006229-7yoilsho	631	12	,	,	,
cord-006229-7yoilsho	631	13	was	be	VBD
cord-006229-7yoilsho	631	14	stably	stably	RB
cord-006229-7yoilsho	631	15	transfected	transfecte	VBN
cord-006229-7yoilsho	631	16	alone	alone	RB
cord-006229-7yoilsho	632	1	(	(	-LRB-
cord-006229-7yoilsho	632	2	HekWT	HekWT	NNP
cord-006229-7yoilsho	632	3	-	-	HYPH
cord-006229-7yoilsho	632	4	E1	E1	NNP
cord-006229-7yoilsho	632	5	)	)	-RRB-
cord-006229-7yoilsho	632	6	and	and	CC
cord-006229-7yoilsho	633	1	together	together	RB
cord-006229-7yoilsho	633	2	with	with	IN
cord-006229-7yoilsho	633	3	a	a	DT
cord-006229-7yoilsho	633	4	moderate	moderate	JJ
cord-006229-7yoilsho	633	5	level	level	NN
cord-006229-7yoilsho	633	6	of	of	IN
cord-006229-7yoilsho	633	7	native	native	JJ
cord-006229-7yoilsho	633	8	ß	ß	NN
cord-006229-7yoilsho	633	9	1	1	CD
cord-006229-7yoilsho	633	10	AR	AR	NNP
cord-006229-7yoilsho	633	11	to	to	IN
cord-006229-7yoilsho	633	12	HEK293	HEK293	NNP
cord-006229-7yoilsho	633	13	cells	cell	NNS
cord-006229-7yoilsho	633	14	(	(	-LRB-
cord-006229-7yoilsho	633	15	Hekß	Hekß	NNP
cord-006229-7yoilsho	633	16	1	1	CD
cord-006229-7yoilsho	633	17	-E1	-e1	NN
cord-006229-7yoilsho	633	18	;	;	.
cord-006229-7yoilsho	634	1	Nikolaev	Nikolaev	NNP
cord-006229-7yoilsho	634	2	et	et	FW
cord-006229-7yoilsho	634	3	al	al	NNP
cord-006229-7yoilsho	634	4	.	.	.
cord-006229-7yoilsho	635	1	JACC	JACC	NNP
cord-006229-7yoilsho	635	2	50	50	CD
cord-006229-7yoilsho	635	3	:	:	SYM
cord-006229-7yoilsho	635	4	423	423	CD
cord-006229-7yoilsho	635	5	,	,	,
cord-006229-7yoilsho	635	6	2007	2007	CD
cord-006229-7yoilsho	635	7	)	)	-RRB-
cord-006229-7yoilsho	635	8	.	.	.
cord-006229-7yoilsho	636	1	FRET	fret	NN
cord-006229-7yoilsho	636	2	-	-	HYPH
cord-006229-7yoilsho	636	3	activity	activity	NN
cord-006229-7yoilsho	636	4	was	be	VBD
cord-006229-7yoilsho	636	5	measured	measure	VBN
cord-006229-7yoilsho	636	6	with	with	IN
cord-006229-7yoilsho	636	7	recently	recently	RB
cord-006229-7yoilsho	636	8	developed	develop	VBN
cord-006229-7yoilsho	636	9	fluorescence	fluorescence	NN
cord-006229-7yoilsho	636	10	detectors	detector	NNS
cord-006229-7yoilsho	636	11	(	(	-LRB-
cord-006229-7yoilsho	636	12	12	12	CD
cord-006229-7yoilsho	636	13	channels	channel	NNS
cord-006229-7yoilsho	636	14	)	)	-RRB-
cord-006229-7yoilsho	636	15	equipped	equip	VBN
cord-006229-7yoilsho	636	16	with	with	IN
cord-006229-7yoilsho	636	17	fast	fast	JJ
cord-006229-7yoilsho	636	18	semiconductor	semiconductor	NN
cord-006229-7yoilsho	636	19	technology	technology	NN
cord-006229-7yoilsho	636	20	,	,	,
cord-006229-7yoilsho	636	21	avoiding	avoid	VBG
cord-006229-7yoilsho	636	22	any	any	DT
cord-006229-7yoilsho	636	23	movable	movable	JJ
cord-006229-7yoilsho	636	24	optical	optical	JJ
cord-006229-7yoilsho	636	25	and	and	CC
cord-006229-7yoilsho	636	26	mechanical	mechanical	JJ
cord-006229-7yoilsho	636	27	parts	part	NNS
cord-006229-7yoilsho	636	28	,	,	,
cord-006229-7yoilsho	636	29	using	use	VBG
cord-006229-7yoilsho	636	30	438	438	CD
cord-006229-7yoilsho	636	31	nm	nm	NN
cord-006229-7yoilsho	636	32	for	for	IN
cord-006229-7yoilsho	636	33	excitation	excitation	NN
cord-006229-7yoilsho	636	34	and	and	CC
cord-006229-7yoilsho	636	35	483/540	483/540	CD
cord-006229-7yoilsho	636	36	nm	nm	NN
cord-006229-7yoilsho	636	37	for	for	IN
cord-006229-7yoilsho	636	38	the	the	DT
cord-006229-7yoilsho	636	39	emmission	emmission	NN
cord-006229-7yoilsho	636	40	ratio	ratio	NN
cord-006229-7yoilsho	636	41	.	.	.
cord-006229-7yoilsho	637	1	Cells	cell	NNS
cord-006229-7yoilsho	637	2	were	be	VBD
cord-006229-7yoilsho	637	3	cultivated	cultivate	VBN
cord-006229-7yoilsho	637	4	in	in	IN
cord-006229-7yoilsho	637	5	96-format	96-format	CD
cord-006229-7yoilsho	637	6	12-well	12-well	CD
cord-006229-7yoilsho	637	7	strips	strip	NNS
cord-006229-7yoilsho	637	8	,	,	,
cord-006229-7yoilsho	637	9	incubated	incubate	VBN
cord-006229-7yoilsho	637	10	in	in	IN
cord-006229-7yoilsho	637	11	physiological	physiological	JJ
cord-006229-7yoilsho	637	12	HEPES	hepes	NN
cord-006229-7yoilsho	637	13	-	-	HYPH
cord-006229-7yoilsho	637	14	buffered	buffer	VBN
cord-006229-7yoilsho	637	15	salt	salt	NN
cord-006229-7yoilsho	637	16	solution	solution	NN
cord-006229-7yoilsho	637	17	and	and	CC
cord-006229-7yoilsho	637	18	treated	treat	VBN
cord-006229-7yoilsho	637	19	with	with	IN
cord-006229-7yoilsho	637	20	ßAR	ßar	NN
cord-006229-7yoilsho	637	21	agonists	agonist	NNS
cord-006229-7yoilsho	637	22	of	of	IN
cord-006229-7yoilsho	637	23	different	different	JJ
cord-006229-7yoilsho	637	24	selectivity	selectivity	NN
cord-006229-7yoilsho	637	25	and	and	CC
cord-006229-7yoilsho	637	26	affinity	affinity	NN
cord-006229-7yoilsho	637	27	to	to	TO
cord-006229-7yoilsho	637	28	determine	determine	VB
cord-006229-7yoilsho	637	29	their	-PRON-	PRP$
cord-006229-7yoilsho	637	30	ßAR	ßar	NN
cord-006229-7yoilsho	637	31	-	-	HYPH
cord-006229-7yoilsho	637	32	subtype	subtype	NN
cord-006229-7yoilsho	637	33	preference	preference	NN
cord-006229-7yoilsho	637	34	.	.	.
cord-006229-7yoilsho	638	1	Catecholamines	Catecholamines	NNP
cord-006229-7yoilsho	638	2	tested	test	VBN
cord-006229-7yoilsho	638	3	in	in	IN
cord-006229-7yoilsho	638	4	Hekß	Hekß	NNP
cord-006229-7yoilsho	638	5	1	1	CD
cord-006229-7yoilsho	639	1	-Fret	-fret	NN
cord-006229-7yoilsho	639	2	cells	cell	NNS
cord-006229-7yoilsho	639	3	exhibited	exhibit	VBD
cord-006229-7yoilsho	639	4	EC	EC	NNP
cord-006229-7yoilsho	639	5	50	50	CD
cord-006229-7yoilsho	639	6	-values	-value	NNS
cord-006229-7yoilsho	640	1	(	(	-LRB-
cord-006229-7yoilsho	640	2	-log	-log	:
cord-006229-7yoilsho	640	3	,	,	,
cord-006229-7yoilsho	640	4	M	M	NNP
cord-006229-7yoilsho	640	5	)	)	-RRB-
cord-006229-7yoilsho	640	6	which	which	WDT
cord-006229-7yoilsho	640	7	matched	match	VBD
cord-006229-7yoilsho	640	8	K	K	NNP
cord-006229-7yoilsho	640	9	D	d	NN
cord-006229-7yoilsho	641	1	-values	-values	.
cord-006229-7yoilsho	642	1	(	(	-LRB-
cord-006229-7yoilsho	642	2	-log	-log	:
cord-006229-7yoilsho	642	3	,	,	,
cord-006229-7yoilsho	642	4	M	M	NNP
cord-006229-7yoilsho	642	5	)	)	-RRB-
cord-006229-7yoilsho	642	6	known	know	VBN
cord-006229-7yoilsho	642	7	from	from	IN
cord-006229-7yoilsho	642	8	native	native	JJ
cord-006229-7yoilsho	642	9	heart	heart	NN
cord-006229-7yoilsho	642	10	receptor	receptor	NN
cord-006229-7yoilsho	642	11	membranes	membrane	NNS
cord-006229-7yoilsho	642	12	(	(	-LRB-
cord-006229-7yoilsho	642	13	isoprenaline	isoprenaline	NNP
cord-006229-7yoilsho	642	14	,	,	,
cord-006229-7yoilsho	642	15	ISO	iso	NN
cord-006229-7yoilsho	642	16	:	:	:
cord-006229-7yoilsho	642	17	6.9±0.1	6.9±0.1	CD
cord-006229-7yoilsho	642	18	,	,	,
cord-006229-7yoilsho	642	19	adrenaline	adrenaline	NN
cord-006229-7yoilsho	642	20	5.7±0.1	5.7±0.1	CD
cord-006229-7yoilsho	642	21	,	,	,
cord-006229-7yoilsho	642	22	noradrenaline	noradrenaline	NN
cord-006229-7yoilsho	642	23	6.2±0.1	6.2±0.1	CD
cord-006229-7yoilsho	642	24	)	)	-RRB-
cord-006229-7yoilsho	642	25	.	.	.
cord-006229-7yoilsho	643	1	ßAR	ßar	NN
cord-006229-7yoilsho	643	2	-	-	HYPH
cord-006229-7yoilsho	643	3	expression	expression	NN
cord-006229-7yoilsho	643	4	levels	level	NNS
cord-006229-7yoilsho	643	5	were	be	VBD
cord-006229-7yoilsho	643	6	controlled	control	VBN
cord-006229-7yoilsho	643	7	by	by	IN
cord-006229-7yoilsho	643	8	radioligand	radioligand	JJ
cord-006229-7yoilsho	643	9	binding	binding	NN
cord-006229-7yoilsho	643	10	with	with	IN
cord-006229-7yoilsho	643	11	[	[	-LRB-
cord-006229-7yoilsho	643	12	3	3	CD
cord-006229-7yoilsho	643	13	H]-(-)-CGP12,177	h]-(-)-cgp12,177	NN
cord-006229-7yoilsho	643	14	resulting	result	VBG
cord-006229-7yoilsho	643	15	in	in	IN
cord-006229-7yoilsho	643	16	different	different	JJ
cord-006229-7yoilsho	643	17	densities	density	NNS
cord-006229-7yoilsho	643	18	of	of	IN
cord-006229-7yoilsho	643	19	~4x10	~4x10	CD
cord-006229-7yoilsho	643	20	6	6	CD
cord-006229-7yoilsho	643	21	and	and	CC
cord-006229-7yoilsho	643	22	~1.4x10	~1.4x10	CD
cord-006229-7yoilsho	643	23	4	4	CD
cord-006229-7yoilsho	643	24	receptors	receptor	NNS
cord-006229-7yoilsho	643	25	/	/	SYM
cord-006229-7yoilsho	643	26	cell	cell	NN
cord-006229-7yoilsho	643	27	in	in	IN
cord-006229-7yoilsho	643	28	Hekß	Hekß	NNP
cord-006229-7yoilsho	643	29	1	1	CD
cord-006229-7yoilsho	643	30	-Fret	-Fret	NNP
cord-006229-7yoilsho	643	31	and	and	CC
cord-006229-7yoilsho	643	32	Hekß	Hekß	NNP
cord-006229-7yoilsho	643	33	1	1	CD
cord-006229-7yoilsho	643	34	-E1	-e1	NN
cord-006229-7yoilsho	643	35	,	,	,
cord-006229-7yoilsho	643	36	respectively	respectively	RB
cord-006229-7yoilsho	643	37	,	,	,
cord-006229-7yoilsho	643	38	whereas	whereas	IN
cord-006229-7yoilsho	643	39	in	in	IN
cord-006229-7yoilsho	643	40	HekWT	HekWT	NNP
cord-006229-7yoilsho	643	41	-	-	HYPH
cord-006229-7yoilsho	643	42	E1	e1	NN
cord-006229-7yoilsho	643	43	cells	cell	NNS
cord-006229-7yoilsho	643	44	only	only	RB
cord-006229-7yoilsho	643	45	~1000	~1000	CD
cord-006229-7yoilsho	643	46	ß	ß	NN
cord-006229-7yoilsho	643	47	2	2	CD
cord-006229-7yoilsho	643	48	AR	AR	NNPS
cord-006229-7yoilsho	643	49	were	be	VBD
cord-006229-7yoilsho	643	50	found	find	VBN
cord-006229-7yoilsho	643	51	.	.	.
cord-006229-7yoilsho	644	1	Surprisingly	surprisingly	RB
cord-006229-7yoilsho	644	2	,	,	,
cord-006229-7yoilsho	644	3	the	the	DT
cord-006229-7yoilsho	644	4	low	low	JJ
cord-006229-7yoilsho	644	5	level	level	NN
cord-006229-7yoilsho	644	6	of	of	IN
cord-006229-7yoilsho	644	7	ßAR	ßar	NN
cord-006229-7yoilsho	644	8	in	in	IN
cord-006229-7yoilsho	644	9	HekWT	HekWT	NNP
cord-006229-7yoilsho	644	10	-	-	HYPH
cord-006229-7yoilsho	644	11	E1	e1	NN
cord-006229-7yoilsho	644	12	cells	cell	NNS
cord-006229-7yoilsho	644	13	allowed	allow	VBD
cord-006229-7yoilsho	644	14	the	the	DT
cord-006229-7yoilsho	644	15	measurement	measurement	NN
cord-006229-7yoilsho	644	16	of	of	IN
cord-006229-7yoilsho	644	17	the	the	DT
cord-006229-7yoilsho	644	18	action	action	NN
cord-006229-7yoilsho	644	19	of	of	IN
cord-006229-7yoilsho	644	20	ß	ß	NN
cord-006229-7yoilsho	644	21	2	2	CD
cord-006229-7yoilsho	644	22	-sympathomimetics	-sympathomimetic	NNS
cord-006229-7yoilsho	645	1	(	(	-LRB-
cord-006229-7yoilsho	645	2	ß	ß	NN
cord-006229-7yoilsho	645	3	2	2	CD
cord-006229-7yoilsho	645	4	SYM	SYM	NNP
cord-006229-7yoilsho	645	5	)	)	-RRB-
cord-006229-7yoilsho	645	6	,	,	,
cord-006229-7yoilsho	645	7	e.g.	e.g.	RB
cord-006229-7yoilsho	645	8	fenoterol	fenoterol	NNP
cord-006229-7yoilsho	645	9	,	,	,
cord-006229-7yoilsho	645	10	thereby	thereby	RB
cord-006229-7yoilsho	645	11	amplifying	amplify	VBG
cord-006229-7yoilsho	645	12	receptor	receptor	NN
cord-006229-7yoilsho	645	13	binding	binding	NN
cord-006229-7yoilsho	645	14	(	(	-LRB-
cord-006229-7yoilsho	645	15	pK	pK	NNP
cord-006229-7yoilsho	645	16	D~6	D~6	NNP
cord-006229-7yoilsho	645	17	.7	.7	NFP
cord-006229-7yoilsho	645	18	)	)	-RRB-
cord-006229-7yoilsho	645	19	to	to	IN
cord-006229-7yoilsho	645	20	an	an	DT
cord-006229-7yoilsho	645	21	effective	effective	JJ
cord-006229-7yoilsho	645	22	regulation	regulation	NN
cord-006229-7yoilsho	645	23	of	of	IN
cord-006229-7yoilsho	645	24	FRET	fret	NN
cord-006229-7yoilsho	645	25	activity	activity	NN
cord-006229-7yoilsho	645	26	in	in	IN
cord-006229-7yoilsho	645	27	the	the	DT
cord-006229-7yoilsho	645	28	presence	presence	NN
cord-006229-7yoilsho	645	29	of	of	IN
cord-006229-7yoilsho	645	30	0.06	0.06	CD
cord-006229-7yoilsho	645	31	mM	mm	CD
cord-006229-7yoilsho	645	32	IBMX	IBMX	NNP
cord-006229-7yoilsho	645	33	(	(	-LRB-
cord-006229-7yoilsho	645	34	pEC	pEC	NNP
cord-006229-7yoilsho	645	35	50~8	50~8	NNP
cord-006229-7yoilsho	645	36	.3±0.1	.3±0.1	NFP
cord-006229-7yoilsho	645	37	)	)	-RRB-
cord-006229-7yoilsho	645	38	,	,	,
cord-006229-7yoilsho	645	39	nearly	nearly	RB
cord-006229-7yoilsho	645	40	matching	match	VBG
cord-006229-7yoilsho	645	41	the	the	DT
cord-006229-7yoilsho	645	42	~100-fold	~100-fold	NNP
cord-006229-7yoilsho	645	43	amplification	amplification	NN
cord-006229-7yoilsho	645	44	of	of	IN
cord-006229-7yoilsho	645	45	ISO	iso	NN
cord-006229-7yoilsho	645	46	(	(	-LRB-
cord-006229-7yoilsho	645	47	pK	pK	NNP
cord-006229-7yoilsho	645	48	D~6	D~6	NNP
cord-006229-7yoilsho	645	49	.9	.9	NNP
cord-006229-7yoilsho	645	50	;	;	:
cord-006229-7yoilsho	645	51	pEC	pec	NN
cord-006229-7yoilsho	645	52	50~8	50~8	CD
cord-006229-7yoilsho	645	53	.9	.9	NFP
cord-006229-7yoilsho	645	54	)	)	-RRB-
cord-006229-7yoilsho	645	55	.	.	.
cord-006229-7yoilsho	646	1	In	in	IN
cord-006229-7yoilsho	646	2	order	order	NN
cord-006229-7yoilsho	646	3	to	to	TO
cord-006229-7yoilsho	646	4	determine	determine	VB
cord-006229-7yoilsho	646	5	ß	ß	NN
cord-006229-7yoilsho	646	6	1	1	CD
cord-006229-7yoilsho	646	7	AR	AR	NNP
cord-006229-7yoilsho	646	8	-	-	HYPH
cord-006229-7yoilsho	646	9	mediated	mediate	VBN
cord-006229-7yoilsho	646	10	side	side	NN
cord-006229-7yoilsho	646	11	effects	effect	NNS
cord-006229-7yoilsho	646	12	of	of	IN
cord-006229-7yoilsho	646	13	ß	ß	NN
cord-006229-7yoilsho	646	14	2	2	CD
cord-006229-7yoilsho	646	15	SYM	SYM	NNP
cord-006229-7yoilsho	646	16	,	,	,
cord-006229-7yoilsho	646	17	Hekß	Hekß	NNP
cord-006229-7yoilsho	646	18	1	1	CD
cord-006229-7yoilsho	646	19	-E1	-e1	NN
cord-006229-7yoilsho	646	20	cells	cell	NNS
cord-006229-7yoilsho	646	21	characterized	characterize	VBN
cord-006229-7yoilsho	646	22	by	by	IN
cord-006229-7yoilsho	646	23	a	a	DT
cord-006229-7yoilsho	646	24	14-fold	14-fold	CD
cord-006229-7yoilsho	646	25	higher	high	JJR
cord-006229-7yoilsho	646	26	level	level	NN
cord-006229-7yoilsho	646	27	of	of	IN
cord-006229-7yoilsho	646	28	ß	ß	NN
cord-006229-7yoilsho	646	29	1	1	CD
cord-006229-7yoilsho	646	30	AR	AR	NNP
cord-006229-7yoilsho	646	31	over	over	IN
cord-006229-7yoilsho	646	32	ß	ß	NN
cord-006229-7yoilsho	646	33	2	2	CD
cord-006229-7yoilsho	646	34	AR	AR	NNPS
cord-006229-7yoilsho	646	35	were	be	VBD
cord-006229-7yoilsho	646	36	assayed	assay	VBN
cord-006229-7yoilsho	646	37	for	for	IN
cord-006229-7yoilsho	646	38	FRET	fret	NN
cord-006229-7yoilsho	646	39	activity	activity	NN
cord-006229-7yoilsho	646	40	.	.	.
cord-006229-7yoilsho	647	1	Fenoterol	Fenoterol	NNP
cord-006229-7yoilsho	647	2	maximally	maximally	RB
cord-006229-7yoilsho	647	3	inhibited	inhibited	JJ
cord-006229-7yoilsho	647	4	FRET	fret	NN
cord-006229-7yoilsho	647	5	activity	activity	NN
cord-006229-7yoilsho	647	6	with	with	IN
cord-006229-7yoilsho	647	7	a	a	DT
cord-006229-7yoilsho	647	8	pEC	pec	NN
cord-006229-7yoilsho	647	9	50~8	50~8	CD
cord-006229-7yoilsho	647	10	.4	.4	.
cord-006229-7yoilsho	648	1	whereas	whereas	IN
cord-006229-7yoilsho	648	2	the	the	DT
cord-006229-7yoilsho	648	3	high	high	JJ
cord-006229-7yoilsho	648	4	affinity	affinity	NN
cord-006229-7yoilsho	648	5	ß	ß	NN
cord-006229-7yoilsho	648	6	2	2	CD
cord-006229-7yoilsho	648	7	SYM	SYM	NNP
cord-006229-7yoilsho	648	8	salmeterol	salmeterol	NN
cord-006229-7yoilsho	648	9	acted	act	VBD
cord-006229-7yoilsho	648	10	a	a	DT
cord-006229-7yoilsho	648	11	partial	partial	JJ
cord-006229-7yoilsho	648	12	agonist	agonist	NN
cord-006229-7yoilsho	648	13	(	(	-LRB-
cord-006229-7yoilsho	648	14	~75	~75	CD
cord-006229-7yoilsho	648	15	%	%	NN
cord-006229-7yoilsho	648	16	of	of	IN
cord-006229-7yoilsho	648	17	Iso	Iso	NNP
cord-006229-7yoilsho	648	18	maximum	maximum	NN
cord-006229-7yoilsho	648	19	,	,	,
cord-006229-7yoilsho	648	20	pEC	pEC	NNP
cord-006229-7yoilsho	648	21	50~8	50~8	CD
cord-006229-7yoilsho	648	22	.6	.6	CD
cord-006229-7yoilsho	648	23	)	)	-RRB-
cord-006229-7yoilsho	648	24	,	,	,
cord-006229-7yoilsho	648	25	both	both	DT
cord-006229-7yoilsho	648	26	compounds	compound	NNS
cord-006229-7yoilsho	648	27	being	be	VBG
cord-006229-7yoilsho	648	28	rather	rather	RB
cord-006229-7yoilsho	648	29	insensitive	insensitive	JJ
cord-006229-7yoilsho	648	30	against	against	IN
cord-006229-7yoilsho	648	31	the	the	DT
cord-006229-7yoilsho	648	32	highly	highly	RB
cord-006229-7yoilsho	648	33	effective	effective	JJ
cord-006229-7yoilsho	648	34	ß	ß	NN
cord-006229-7yoilsho	648	35	1	1	CD
cord-006229-7yoilsho	648	36	AR	ar	NN
cord-006229-7yoilsho	648	37	-	-	HYPH
cord-006229-7yoilsho	648	38	blockade	blockade	NN
cord-006229-7yoilsho	648	39	with	with	IN
cord-006229-7yoilsho	648	40	1	1	CD
cord-006229-7yoilsho	648	41	µM	µm	NN
cord-006229-7yoilsho	649	1	CGP	CGP	NNP
cord-006229-7yoilsho	649	2	20,712	20,712	CD
cord-006229-7yoilsho	649	3	A.	a.	NN
cord-006229-7yoilsho	650	1	For	for	IN
cord-006229-7yoilsho	650	2	that	that	DT
cord-006229-7yoilsho	650	3	reason	reason	NN
cord-006229-7yoilsho	651	1	Hekß	Hekß	NNP
cord-006229-7yoilsho	651	2	1	1	CD
cord-006229-7yoilsho	651	3	-Fret	-Fret	NNP
cord-006229-7yoilsho	651	4	cells	cell	NNS
cord-006229-7yoilsho	651	5	were	be	VBD
cord-006229-7yoilsho	651	6	used	use	VBN
cord-006229-7yoilsho	651	7	characterizing	characterize	VBG
cord-006229-7yoilsho	651	8	fenoterol	fenoterol	NNP
cord-006229-7yoilsho	651	9	as	as	IN
cord-006229-7yoilsho	651	10	partial	partial	JJ
cord-006229-7yoilsho	651	11	agonist	agonist	NN
cord-006229-7yoilsho	651	12	(	(	-LRB-
cord-006229-7yoilsho	651	13	~25	~25	CD
cord-006229-7yoilsho	651	14	%	%	NN
cord-006229-7yoilsho	651	15	)	)	-RRB-
cord-006229-7yoilsho	651	16	whereas	whereas	IN
cord-006229-7yoilsho	651	17	salmeterol	salmeterol	NN
cord-006229-7yoilsho	651	18	activated	activate	VBD
cord-006229-7yoilsho	651	19	less	less	JJR
cord-006229-7yoilsho	651	20	than	than	IN
cord-006229-7yoilsho	651	21	10	10	CD
cord-006229-7yoilsho	651	22	%	%	NN
cord-006229-7yoilsho	651	23	of	of	IN
cord-006229-7yoilsho	651	24	maximum	maximum	JJ
cord-006229-7yoilsho	651	25	receptor	receptor	NN
cord-006229-7yoilsho	651	26	activation	activation	NN
cord-006229-7yoilsho	651	27	by	by	IN
cord-006229-7yoilsho	651	28	ISO	ISO	NNP
cord-006229-7yoilsho	651	29	.	.	.
cord-006229-7yoilsho	652	1	Thus	thus	RB
cord-006229-7yoilsho	652	2	,	,	,
cord-006229-7yoilsho	652	3	it	-PRON-	PRP
cord-006229-7yoilsho	652	4	has	have	VBZ
cord-006229-7yoilsho	652	5	to	to	TO
cord-006229-7yoilsho	652	6	be	be	VB
cord-006229-7yoilsho	652	7	concluded	conclude	VBN
cord-006229-7yoilsho	652	8	that	that	IN
cord-006229-7yoilsho	652	9	the	the	DT
cord-006229-7yoilsho	652	10	low	low	JJ
cord-006229-7yoilsho	652	11	level	level	NN
cord-006229-7yoilsho	652	12	of	of	IN
cord-006229-7yoilsho	652	13	effectively	effectively	RB
cord-006229-7yoilsho	652	14	coupled	couple	VBN
cord-006229-7yoilsho	652	15	WT	WT	NNP
cord-006229-7yoilsho	652	16	-	-	HYPH
cord-006229-7yoilsho	652	17	ß	ß	NN
cord-006229-7yoilsho	652	18	2	2	CD
cord-006229-7yoilsho	652	19	AR	AR	NNP
cord-006229-7yoilsho	652	20	present	present	JJ
cord-006229-7yoilsho	652	21	in	in	IN
cord-006229-7yoilsho	652	22	Hekß	Hekß	NNP
cord-006229-7yoilsho	652	23	1	1	CD
cord-006229-7yoilsho	652	24	-E1	-e1	NN
cord-006229-7yoilsho	652	25	cells	cell	NNS
cord-006229-7yoilsho	652	26	precludes	preclude	VBZ
cord-006229-7yoilsho	652	27	the	the	DT
cord-006229-7yoilsho	652	28	exact	exact	JJ
cord-006229-7yoilsho	652	29	determination	determination	NN
cord-006229-7yoilsho	652	30	of	of	IN
cord-006229-7yoilsho	652	31	ß	ß	NN
cord-006229-7yoilsho	652	32	1	1	CD
cord-006229-7yoilsho	652	33	AR	AR	NNP
cord-006229-7yoilsho	652	34	-	-	HYPH
cord-006229-7yoilsho	652	35	mediated	mediate	VBN
cord-006229-7yoilsho	652	36	side	side	NN
cord-006229-7yoilsho	652	37	effects	effect	NNS
cord-006229-7yoilsho	652	38	of	of	IN
cord-006229-7yoilsho	652	39	ß	ß	NN
cord-006229-7yoilsho	652	40	2	2	CD
cord-006229-7yoilsho	652	41	SYM	sym	NN
cord-006229-7yoilsho	652	42	,	,	,
cord-006229-7yoilsho	652	43	and	and	CC
cord-006229-7yoilsho	652	44	that	that	IN
cord-006229-7yoilsho	652	45	CFP	CFP	NNP
cord-006229-7yoilsho	652	46	/	/	SYM
cord-006229-7yoilsho	652	47	YFP	YFP	NNP
cord-006229-7yoilsho	652	48	labelled	label	VBD
cord-006229-7yoilsho	652	49	receptors	receptor	NNS
cord-006229-7yoilsho	652	50	have	have	VBP
cord-006229-7yoilsho	652	51	to	to	TO
cord-006229-7yoilsho	652	52	be	be	VB
cord-006229-7yoilsho	652	53	used	use	VBN
cord-006229-7yoilsho	652	54	for	for	IN
cord-006229-7yoilsho	652	55	the	the	DT
cord-006229-7yoilsho	652	56	determination	determination	NN
cord-006229-7yoilsho	652	57	of	of	IN
cord-006229-7yoilsho	652	58	the	the	DT
cord-006229-7yoilsho	652	59	subtype	subtype	NN
cord-006229-7yoilsho	652	60	specific	specific	JJ
cord-006229-7yoilsho	652	61	intrinsic	intrinsic	JJ
cord-006229-7yoilsho	652	62	activity	activity	NN
cord-006229-7yoilsho	652	63	of	of	IN
cord-006229-7yoilsho	652	64	an	an	DT
cord-006229-7yoilsho	652	65	agonist	agonist	NN
cord-006229-7yoilsho	652	66	.	.	.
cord-006229-7yoilsho	653	1	They	-PRON-	PRP
cord-006229-7yoilsho	653	2	account	account	VBP
cord-006229-7yoilsho	653	3	for	for	IN
cord-006229-7yoilsho	653	4	about	about	RB
cord-006229-7yoilsho	653	5	one	one	CD
cord-006229-7yoilsho	653	6	third	third	NN
cord-006229-7yoilsho	653	7	of	of	IN
cord-006229-7yoilsho	653	8	all	all	DT
cord-006229-7yoilsho	653	9	drug	drug	NN
cord-006229-7yoilsho	653	10	targets	target	NNS
cord-006229-7yoilsho	653	11	.	.	.
cord-006229-7yoilsho	654	1	Their	-PRON-	PRP$
cord-006229-7yoilsho	654	2	regulation	regulation	NN
cord-006229-7yoilsho	654	3	from	from	IN
cord-006229-7yoilsho	654	4	desensitization	desensitization	NN
cord-006229-7yoilsho	654	5	to	to	IN
cord-006229-7yoilsho	654	6	internalization	internalization	NN
cord-006229-7yoilsho	654	7	and	and	CC
cord-006229-7yoilsho	654	8	alternative	alternative	JJ
cord-006229-7yoilsho	654	9	signal	signal	NN
cord-006229-7yoilsho	654	10	transduction	transduction	NN
cord-006229-7yoilsho	654	11	is	be	VBZ
cord-006229-7yoilsho	654	12	largely	largely	RB
cord-006229-7yoilsho	654	13	dependent	dependent	JJ
cord-006229-7yoilsho	654	14	on	on	IN
cord-006229-7yoilsho	654	15	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	654	16	of	of	IN
cord-006229-7yoilsho	654	17	intracellular	intracellular	JJ
cord-006229-7yoilsho	654	18	serine	serine	NN
cord-006229-7yoilsho	654	19	and	and	CC
cord-006229-7yoilsho	654	20	threonine	threonine	NN
cord-006229-7yoilsho	654	21	residues	residue	NNS
cord-006229-7yoilsho	654	22	of	of	IN
cord-006229-7yoilsho	654	23	the	the	DT
cord-006229-7yoilsho	654	24	activated	activate	VBN
cord-006229-7yoilsho	654	25	receptor	receptor	NN
cord-006229-7yoilsho	654	26	.	.	.
cord-006229-7yoilsho	655	1	Even	even	RB
cord-006229-7yoilsho	655	2	though	though	IN
cord-006229-7yoilsho	655	3	the	the	DT
cord-006229-7yoilsho	655	4	β	β	NN
cord-006229-7yoilsho	655	5	1	1	CD
cord-006229-7yoilsho	655	6	-adrenoceptor	-adrenoceptor	NN
cord-006229-7yoilsho	655	7	is	be	VBZ
cord-006229-7yoilsho	655	8	of	of	IN
cord-006229-7yoilsho	655	9	tremendous	tremendous	JJ
cord-006229-7yoilsho	655	10	importance	importance	NN
cord-006229-7yoilsho	655	11	in	in	IN
cord-006229-7yoilsho	655	12	a	a	DT
cord-006229-7yoilsho	655	13	number	number	NN
cord-006229-7yoilsho	655	14	of	of	IN
cord-006229-7yoilsho	655	15	diseases	disease	NNS
cord-006229-7yoilsho	655	16	its	-PRON-	PRP$
cord-006229-7yoilsho	655	17	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	655	18	remains	remain	VBZ
cord-006229-7yoilsho	655	19	poorly	poorly	RB
cord-006229-7yoilsho	655	20	understood	understand	VBN
cord-006229-7yoilsho	655	21	.	.	.
cord-006229-7yoilsho	656	1	We	-PRON-	PRP
cord-006229-7yoilsho	656	2	addressed	address	VBD
cord-006229-7yoilsho	656	3	this	this	DT
cord-006229-7yoilsho	656	4	question	question	NN
cord-006229-7yoilsho	656	5	in	in	IN
cord-006229-7yoilsho	656	6	a	a	DT
cord-006229-7yoilsho	656	7	qualitative	qualitative	JJ
cord-006229-7yoilsho	656	8	and	and	CC
cord-006229-7yoilsho	656	9	quantitative	quantitative	JJ
cord-006229-7yoilsho	656	10	way	way	NN
cord-006229-7yoilsho	656	11	.	.	.
cord-006229-7yoilsho	657	1	By	by	IN
cord-006229-7yoilsho	657	2	using	use	VBG
cord-006229-7yoilsho	657	3	radioactive	radioactive	JJ
cord-006229-7yoilsho	657	4	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	657	5	assays	assay	NNS
cord-006229-7yoilsho	657	6	and	and	CC
cord-006229-7yoilsho	657	7	mass	mass	NN
cord-006229-7yoilsho	657	8	spectrometry	spectrometry	NN
cord-006229-7yoilsho	657	9	,	,	,
cord-006229-7yoilsho	657	10	we	-PRON-	PRP
cord-006229-7yoilsho	657	11	were	be	VBD
cord-006229-7yoilsho	657	12	able	able	JJ
cord-006229-7yoilsho	657	13	to	to	TO
cord-006229-7yoilsho	657	14	elucidate	elucidate	VB
cord-006229-7yoilsho	657	15	the	the	DT
cord-006229-7yoilsho	657	16	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	657	17	pattern	pattern	NN
cord-006229-7yoilsho	657	18	of	of	IN
cord-006229-7yoilsho	657	19	the	the	DT
cord-006229-7yoilsho	657	20	human	human	NN
cord-006229-7yoilsho	657	21	β	β	NN
cord-006229-7yoilsho	657	22	1	1	CD
cord-006229-7yoilsho	657	23	-adrenoceptor	-adrenoceptor	:
cord-006229-7yoilsho	657	24	in	in	RP
cord-006229-7yoilsho	657	25	vitro	vitro	FW
cord-006229-7yoilsho	657	26	.	.	.
cord-006229-7yoilsho	658	1	We	-PRON-	PRP
cord-006229-7yoilsho	658	2	identified	identify	VBD
cord-006229-7yoilsho	658	3	ten	ten	CD
cord-006229-7yoilsho	658	4	previously	previously	RB
cord-006229-7yoilsho	658	5	unknown	unknown	JJ
cord-006229-7yoilsho	658	6	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	658	7	sites	site	NNS
cord-006229-7yoilsho	658	8	in	in	IN
cord-006229-7yoilsho	658	9	the	the	DT
cord-006229-7yoilsho	658	10	third	third	JJ
cord-006229-7yoilsho	658	11	intracellular	intracellular	JJ
cord-006229-7yoilsho	658	12	loop	loop	NN
cord-006229-7yoilsho	658	13	and	and	CC
cord-006229-7yoilsho	658	14	the	the	DT
cord-006229-7yoilsho	658	15	receptor	receptor	NN
cord-006229-7yoilsho	658	16	's	's	POS
cord-006229-7yoilsho	658	17	C	c	NN
cord-006229-7yoilsho	658	18	-	-	HYPH
cord-006229-7yoilsho	658	19	terminus	terminus	NN
cord-006229-7yoilsho	658	20	.	.	.
cord-006229-7yoilsho	659	1	Labeling	label	VBG
cord-006229-7yoilsho	659	2	HEK293	HEK293	NNP
cord-006229-7yoilsho	659	3	cells	cell	NNS
cord-006229-7yoilsho	659	4	with	with	IN
cord-006229-7yoilsho	659	5	stable	stable	JJ
cord-006229-7yoilsho	659	6	heavy	heavy	JJ
cord-006229-7yoilsho	659	7	isotopes	isotope	NNS
cord-006229-7yoilsho	659	8	(	(	-LRB-
cord-006229-7yoilsho	659	9	SILAC	SILAC	NNP
cord-006229-7yoilsho	659	10	)	)	-RRB-
cord-006229-7yoilsho	659	11	lead	lead	NN
cord-006229-7yoilsho	659	12	to	to	IN
cord-006229-7yoilsho	659	13	the	the	DT
cord-006229-7yoilsho	659	14	discovery	discovery	NN
cord-006229-7yoilsho	659	15	of	of	IN
cord-006229-7yoilsho	659	16	a	a	DT
cord-006229-7yoilsho	659	17	stimulation	stimulation	NN
cord-006229-7yoilsho	659	18	-	-	HYPH
cord-006229-7yoilsho	659	19	dependent	dependent	JJ
cord-006229-7yoilsho	659	20	regulation	regulation	NN
cord-006229-7yoilsho	659	21	of	of	IN
cord-006229-7yoilsho	659	22	several	several	JJ
cord-006229-7yoilsho	659	23	of	of	IN
cord-006229-7yoilsho	659	24	these	these	DT
cord-006229-7yoilsho	659	25	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	659	26	sites	site	NNS
cord-006229-7yoilsho	659	27	.	.	.
cord-006229-7yoilsho	660	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	660	2	,	,	,
cord-006229-7yoilsho	660	3	mutagenesis	mutagenesis	NN
cord-006229-7yoilsho	660	4	studies	study	NNS
cord-006229-7yoilsho	660	5	in	in	IN
cord-006229-7yoilsho	660	6	stably	stably	RB
cord-006229-7yoilsho	660	7	transfected	transfecte	VBN
cord-006229-7yoilsho	660	8	HEK293	HEK293	NNP
cord-006229-7yoilsho	660	9	cells	cell	NNS
cord-006229-7yoilsho	660	10	revealed	reveal	VBD
cord-006229-7yoilsho	660	11	the	the	DT
cord-006229-7yoilsho	660	12	impact	impact	NN
cord-006229-7yoilsho	660	13	of	of	IN
cord-006229-7yoilsho	660	14	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	660	15	for	for	IN
cord-006229-7yoilsho	660	16	arrestin	arrestin	NN
cord-006229-7yoilsho	660	17	binding	binding	NN
cord-006229-7yoilsho	660	18	and	and	CC
cord-006229-7yoilsho	660	19	internalization	internalization	NN
cord-006229-7yoilsho	660	20	of	of	IN
cord-006229-7yoilsho	660	21	the	the	DT
cord-006229-7yoilsho	660	22	receptor	receptor	NN
cord-006229-7yoilsho	660	23	.	.	.
cord-006229-7yoilsho	661	1	Fluorescence	fluorescence	NN
cord-006229-7yoilsho	661	2	resonance	resonance	NN
cord-006229-7yoilsho	661	3	energy	energy	NN
cord-006229-7yoilsho	661	4	transfer	transfer	NN
cord-006229-7yoilsho	661	5	experiments	experiment	NNS
cord-006229-7yoilsho	661	6	with	with	IN
cord-006229-7yoilsho	661	7	β	β	NN
cord-006229-7yoilsho	661	8	1	1	CD
cord-006229-7yoilsho	661	9	-adrenoceptor	-adrenoceptor	NN
cord-006229-7yoilsho	661	10	variants	variant	NNS
cord-006229-7yoilsho	661	11	carrying	carry	VBG
cord-006229-7yoilsho	661	12	point	point	NN
cord-006229-7yoilsho	661	13	mutations	mutation	NNS
cord-006229-7yoilsho	661	14	of	of	IN
cord-006229-7yoilsho	661	15	putative	putative	JJ
cord-006229-7yoilsho	661	16	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	661	17	sites	site	NNS
cord-006229-7yoilsho	661	18	identified	identify	VBD
cord-006229-7yoilsho	661	19	two	two	CD
cord-006229-7yoilsho	661	20	C	c	NN
cord-006229-7yoilsho	661	21	-	-	HYPH
cord-006229-7yoilsho	661	22	terminal	terminal	NN
cord-006229-7yoilsho	661	23	phosphosites	phosphosite	NNS
cord-006229-7yoilsho	661	24	that	that	WDT
cord-006229-7yoilsho	661	25	determine	determine	VBP
cord-006229-7yoilsho	661	26	arrestin	arrestin	NNP
cord-006229-7yoilsho	661	27	recruitment	recruitment	VB
cord-006229-7yoilsho	661	28	.	.	.
cord-006229-7yoilsho	662	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	662	2	current	current	JJ
cord-006229-7yoilsho	662	3	goal	goal	NN
cord-006229-7yoilsho	662	4	is	be	VBZ
cord-006229-7yoilsho	662	5	to	to	TO
cord-006229-7yoilsho	662	6	further	further	RB
cord-006229-7yoilsho	662	7	investigate	investigate	VB
cord-006229-7yoilsho	662	8	the	the	DT
cord-006229-7yoilsho	662	9	functional	functional	JJ
cord-006229-7yoilsho	662	10	implications	implication	NNS
cord-006229-7yoilsho	662	11	of	of	IN
cord-006229-7yoilsho	662	12	these	these	DT
cord-006229-7yoilsho	662	13	newly	newly	RB
cord-006229-7yoilsho	662	14	identified	identify	VBN
cord-006229-7yoilsho	662	15	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	662	16	sites	site	NNS
cord-006229-7yoilsho	662	17	on	on	IN
cord-006229-7yoilsho	662	18	downstream	downstream	JJ
cord-006229-7yoilsho	662	19	signal	signal	NN
cord-006229-7yoilsho	662	20	transduction	transduction	NN
cord-006229-7yoilsho	662	21	,	,	,
cord-006229-7yoilsho	662	22	with	with	IN
cord-006229-7yoilsho	662	23	an	an	DT
cord-006229-7yoilsho	662	24	emphasis	emphasis	NN
cord-006229-7yoilsho	662	25	on	on	IN
cord-006229-7yoilsho	662	26	the	the	DT
cord-006229-7yoilsho	662	27	MAP	map	NN
cord-006229-7yoilsho	662	28	kinase	kinase	NN
cord-006229-7yoilsho	662	29	pathway	pathway	NN
cord-006229-7yoilsho	662	30	.	.	.
cord-006229-7yoilsho	663	1	A	a	DT
cord-006229-7yoilsho	663	2	moderate	moderate	JJ
cord-006229-7yoilsho	663	3	increase	increase	NN
cord-006229-7yoilsho	663	4	in	in	IN
cord-006229-7yoilsho	663	5	arrestin	arrestin	JJ
cord-006229-7yoilsho	663	6	affinity	affinity	NN
cord-006229-7yoilsho	663	7	to	to	IN
cord-006229-7yoilsho	663	8	the	the	DT
cord-006229-7yoilsho	663	9	β	β	NN
cord-006229-7yoilsho	663	10	2	2	CD
cord-006229-7yoilsho	663	11	-adrenergic	-adrenergic	JJ
cord-006229-7yoilsho	663	12	receptor	receptor	NN
cord-006229-7yoilsho	663	13	is	be	VBZ
cord-006229-7yoilsho	663	14	sufficient	sufficient	JJ
cord-006229-7yoilsho	663	15	to	to	TO
cord-006229-7yoilsho	663	16	induce	induce	VB
cord-006229-7yoilsho	663	17	arrestin	arrestin	JJ
cord-006229-7yoilsho	663	18	internalization	internalization	NN
cord-006229-7yoilsho	663	19	.	.	.
cord-006229-7yoilsho	664	1	The	the	DT
cord-006229-7yoilsho	664	2	homologous	homologous	JJ
cord-006229-7yoilsho	664	3	desensitization	desensitization	NN
cord-006229-7yoilsho	664	4	of	of	IN
cord-006229-7yoilsho	664	5	G	g	NN
cord-006229-7yoilsho	664	6	-	-	HYPH
cord-006229-7yoilsho	664	7	protein	protein	NN
cord-006229-7yoilsho	664	8	-	-	HYPH
cord-006229-7yoilsho	664	9	coupled	couple	VBN
cord-006229-7yoilsho	664	10	receptors	receptor	NNS
cord-006229-7yoilsho	664	11	is	be	VBZ
cord-006229-7yoilsho	664	12	a	a	DT
cord-006229-7yoilsho	664	13	two	two	CD
cord-006229-7yoilsho	664	14	-	-	HYPH
cord-006229-7yoilsho	664	15	step	step	NN
cord-006229-7yoilsho	664	16	process	process	NN
cord-006229-7yoilsho	664	17	.	.	.
cord-006229-7yoilsho	665	1	Initially	initially	RB
cord-006229-7yoilsho	665	2	,	,	,
cord-006229-7yoilsho	665	3	G	g	NN
cord-006229-7yoilsho	665	4	-	-	HYPH
cord-006229-7yoilsho	665	5	protein	protein	NN
cord-006229-7yoilsho	665	6	-	-	HYPH
cord-006229-7yoilsho	665	7	coupled	couple	VBN
cord-006229-7yoilsho	665	8	receptor	receptor	NN
cord-006229-7yoilsho	665	9	kinases	kinase	NNS
cord-006229-7yoilsho	665	10	phosphorylate	phosphorylate	VBP
cord-006229-7yoilsho	665	11	agonist	agonist	NN
cord-006229-7yoilsho	665	12	-	-	HYPH
cord-006229-7yoilsho	665	13	occupied	occupy	VBN
cord-006229-7yoilsho	665	14	receptors	receptor	NNS
cord-006229-7yoilsho	665	15	which	which	WDT
cord-006229-7yoilsho	665	16	are	be	VBP
cord-006229-7yoilsho	665	17	subsequently	subsequently	RB
cord-006229-7yoilsho	665	18	bound	bind	VBN
cord-006229-7yoilsho	665	19	by	by	IN
cord-006229-7yoilsho	665	20	arrestins	arrestin	NNS
cord-006229-7yoilsho	665	21	.	.	.
cord-006229-7yoilsho	666	1	In	in	IN
cord-006229-7yoilsho	666	2	many	many	JJ
cord-006229-7yoilsho	666	3	cases	case	NNS
cord-006229-7yoilsho	666	4	,	,	,
cord-006229-7yoilsho	666	5	the	the	DT
cord-006229-7yoilsho	666	6	resulting	result	VBG
cord-006229-7yoilsho	666	7	receptorarrestin	receptorarrestin	NNP
cord-006229-7yoilsho	666	8	complex	complex	NN
cord-006229-7yoilsho	666	9	is	be	VBZ
cord-006229-7yoilsho	666	10	then	then	RB
cord-006229-7yoilsho	666	11	internalized	internalize	VBN
cord-006229-7yoilsho	666	12	via	via	IN
cord-006229-7yoilsho	666	13	clathrin	clathrin	NN
cord-006229-7yoilsho	666	14	-	-	HYPH
cord-006229-7yoilsho	666	15	coated	coat	VBN
cord-006229-7yoilsho	666	16	pits	pit	NNS
cord-006229-7yoilsho	666	17	.	.	.
cord-006229-7yoilsho	667	1	Dependent	dependent	JJ
cord-006229-7yoilsho	667	2	on	on	IN
cord-006229-7yoilsho	667	3	the	the	DT
cord-006229-7yoilsho	667	4	identity	identity	NN
cord-006229-7yoilsho	667	5	of	of	IN
cord-006229-7yoilsho	667	6	the	the	DT
cord-006229-7yoilsho	667	7	receptor	receptor	NN
cord-006229-7yoilsho	667	8	and	and	CC
cord-006229-7yoilsho	667	9	the	the	DT
cord-006229-7yoilsho	667	10	ligand	ligand	NN
cord-006229-7yoilsho	667	11	,	,	,
cord-006229-7yoilsho	667	12	the	the	DT
cord-006229-7yoilsho	667	13	complex	complex	NN
cord-006229-7yoilsho	667	14	between	between	IN
cord-006229-7yoilsho	667	15	receptor	receptor	NN
cord-006229-7yoilsho	667	16	and	and	CC
cord-006229-7yoilsho	667	17	arrestin	arrestin	NN
cord-006229-7yoilsho	667	18	may	may	MD
cord-006229-7yoilsho	667	19	exist	exist	VB
cord-006229-7yoilsho	667	20	only	only	RB
cord-006229-7yoilsho	667	21	in	in	IN
cord-006229-7yoilsho	667	22	the	the	DT
cord-006229-7yoilsho	667	23	proximity	proximity	NN
cord-006229-7yoilsho	667	24	of	of	IN
cord-006229-7yoilsho	667	25	the	the	DT
cord-006229-7yoilsho	667	26	plasma	plasma	NN
cord-006229-7yoilsho	667	27	membrane	membrane	NN
cord-006229-7yoilsho	667	28	or	or	CC
cord-006229-7yoilsho	667	29	internalize	internalize	VB
cord-006229-7yoilsho	667	30	into	into	IN
cord-006229-7yoilsho	667	31	the	the	DT
cord-006229-7yoilsho	667	32	cell	cell	NN
cord-006229-7yoilsho	667	33	interior	interior	NN
cord-006229-7yoilsho	667	34	.	.	.
cord-006229-7yoilsho	668	1	We	-PRON-	PRP
cord-006229-7yoilsho	668	2	constructed	construct	VBD
cord-006229-7yoilsho	668	3	mutants	mutant	NNS
cord-006229-7yoilsho	668	4	of	of	IN
cord-006229-7yoilsho	668	5	the	the	DT
cord-006229-7yoilsho	668	6	β	β	NN
cord-006229-7yoilsho	668	7	2	2	CD
cord-006229-7yoilsho	668	8	-adrenergic	-adrenergic	JJ
cord-006229-7yoilsho	668	9	receptor	receptor	NN
cord-006229-7yoilsho	668	10	carrying	carry	VBG
cord-006229-7yoilsho	668	11	three	three	CD
cord-006229-7yoilsho	668	12	additional	additional	JJ
cord-006229-7yoilsho	668	13	Serine	serine	NN
cord-006229-7yoilsho	668	14	residues	residue	NNS
cord-006229-7yoilsho	668	15	in	in	IN
cord-006229-7yoilsho	668	16	various	various	JJ
cord-006229-7yoilsho	668	17	positions	position	NNS
cord-006229-7yoilsho	668	18	at	at	IN
cord-006229-7yoilsho	668	19	the	the	DT
cord-006229-7yoilsho	668	20	C	C	NNP
cord-006229-7yoilsho	668	21	-	-	HYPH
cord-006229-7yoilsho	668	22	terminal	terminal	NN
cord-006229-7yoilsho	668	23	tail	tail	NN
cord-006229-7yoilsho	668	24	.	.	.
cord-006229-7yoilsho	669	1	One	one	CD
cord-006229-7yoilsho	669	2	of	of	IN
cord-006229-7yoilsho	669	3	these	these	DT
cord-006229-7yoilsho	669	4	mutants	mutant	NNS
cord-006229-7yoilsho	669	5	which	which	WDT
cord-006229-7yoilsho	669	6	carried	carry	VBD
cord-006229-7yoilsho	669	7	the	the	DT
cord-006229-7yoilsho	669	8	Serine	serine	JJ
cord-006229-7yoilsho	669	9	residues	residue	NNS
cord-006229-7yoilsho	669	10	in	in	IN
cord-006229-7yoilsho	669	11	close	close	JJ
cord-006229-7yoilsho	669	12	proximity	proximity	NN
cord-006229-7yoilsho	669	13	to	to	IN
cord-006229-7yoilsho	669	14	the	the	DT
cord-006229-7yoilsho	669	15	endogenous	endogenous	JJ
cord-006229-7yoilsho	669	16	GRK	GRK	NNP
cord-006229-7yoilsho	669	17	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	669	18	sites	site	NNS
cord-006229-7yoilsho	669	19	(	(	-LRB-
cord-006229-7yoilsho	669	20	β	β	NN
cord-006229-7yoilsho	669	21	2	2	CD
cord-006229-7yoilsho	669	22	AR	AR	NNP
cord-006229-7yoilsho	669	23	-	-	HYPH
cord-006229-7yoilsho	669	24	SSS	SSS	NNP
cord-006229-7yoilsho	669	25	)	)	-RRB-
cord-006229-7yoilsho	669	26	showed	show	VBD
cord-006229-7yoilsho	669	27	increased	increase	VBN
cord-006229-7yoilsho	669	28	isoprenaline	isoprenaline	NN
cord-006229-7yoilsho	669	29	-	-	HYPH
cord-006229-7yoilsho	669	30	stimulated	stimulate	VBN
cord-006229-7yoilsho	669	31	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	669	32	and	and	CC
cord-006229-7yoilsho	669	33	differences	difference	NNS
cord-006229-7yoilsho	669	34	in	in	IN
cord-006229-7yoilsho	669	35	arrestin-3	arrestin-3	IN
cord-006229-7yoilsho	669	36	affinity	affinity	NN
cord-006229-7yoilsho	669	37	and	and	CC
cord-006229-7yoilsho	669	38	trafficking	trafficking	NN
cord-006229-7yoilsho	669	39	.	.	.
cord-006229-7yoilsho	670	1	The	the	DT
cord-006229-7yoilsho	670	2	affinity	affinity	NN
cord-006229-7yoilsho	670	3	of	of	IN
cord-006229-7yoilsho	670	4	arrestin-3	arrestin-3	IN
cord-006229-7yoilsho	670	5	to	to	IN
cord-006229-7yoilsho	670	6	the	the	DT
cord-006229-7yoilsho	670	7	receptor	receptor	NN
cord-006229-7yoilsho	670	8	was	be	VBD
cord-006229-7yoilsho	670	9	measured	measure	VBN
cord-006229-7yoilsho	670	10	by	by	IN
cord-006229-7yoilsho	670	11	fluorescence	fluorescence	NN
cord-006229-7yoilsho	670	12	resonance	resonance	NN
cord-006229-7yoilsho	670	13	energy	energy	NN
cord-006229-7yoilsho	670	14	transfer	transfer	NN
cord-006229-7yoilsho	670	15	(	(	-LRB-
cord-006229-7yoilsho	670	16	FRET	fret	NN
cord-006229-7yoilsho	670	17	)	)	-RRB-
cord-006229-7yoilsho	670	18	between	between	IN
cord-006229-7yoilsho	670	19	the	the	DT
cord-006229-7yoilsho	670	20	receptor	receptor	NN
cord-006229-7yoilsho	670	21	and	and	CC
cord-006229-7yoilsho	670	22	arrestin-3	arrestin-3	NNP
cord-006229-7yoilsho	670	23	and	and	CC
cord-006229-7yoilsho	670	24	by	by	IN
cord-006229-7yoilsho	670	25	two	two	CD
cord-006229-7yoilsho	670	26	-	-	HYPH
cord-006229-7yoilsho	670	27	color	color	NN
cord-006229-7yoilsho	670	28	fluorescence	fluorescence	NN
cord-006229-7yoilsho	670	29	recovery	recovery	NN
cord-006229-7yoilsho	670	30	after	after	IN
cord-006229-7yoilsho	670	31	photobleaching	photobleache	VBG
cord-006229-7yoilsho	670	32	(	(	-LRB-
cord-006229-7yoilsho	670	33	FRAP	FRAP	NNP
cord-006229-7yoilsho	670	34	)	)	-RRB-
cord-006229-7yoilsho	670	35	.	.	.
cord-006229-7yoilsho	671	1	In	in	IN
cord-006229-7yoilsho	671	2	the	the	DT
cord-006229-7yoilsho	671	3	FRET	fret	NN
cord-006229-7yoilsho	671	4	assay	assay	NN
cord-006229-7yoilsho	671	5	,	,	,
cord-006229-7yoilsho	671	6	arrestin-3	arrestin-3	IN
cord-006229-7yoilsho	671	7	dissociation	dissociation	NN
cord-006229-7yoilsho	671	8	from	from	IN
cord-006229-7yoilsho	671	9	the	the	DT
cord-006229-7yoilsho	671	10	β	β	NNP
cord-006229-7yoilsho	671	11	2	2	CD
cord-006229-7yoilsho	671	12	AR	AR	NNP
cord-006229-7yoilsho	671	13	-	-	HYPH
cord-006229-7yoilsho	671	14	SSS	SSS	NNP
cord-006229-7yoilsho	671	15	receptor	receptor	NN
cord-006229-7yoilsho	671	16	upon	upon	IN
cord-006229-7yoilsho	671	17	agonist	agonist	NN
cord-006229-7yoilsho	671	18	washout	washout	NN
cord-006229-7yoilsho	671	19	was	be	VBD
cord-006229-7yoilsho	671	20	prolonged	prolong	VBN
cord-006229-7yoilsho	671	21	approximately	approximately	RB
cord-006229-7yoilsho	671	22	two	two	CD
cord-006229-7yoilsho	671	23	-	-	HYPH
cord-006229-7yoilsho	671	24	fold	fold	NN
cord-006229-7yoilsho	671	25	compared	compare	VBN
cord-006229-7yoilsho	671	26	to	to	IN
cord-006229-7yoilsho	671	27	the	the	DT
cord-006229-7yoilsho	671	28	wild	wild	JJ
cord-006229-7yoilsho	671	29	-	-	HYPH
cord-006229-7yoilsho	671	30	type	type	NN
cord-006229-7yoilsho	671	31	receptor	receptor	NN
cord-006229-7yoilsho	671	32	.	.	.
cord-006229-7yoilsho	672	1	FRAP	FRAP	NNP
cord-006229-7yoilsho	672	2	was	be	VBD
cord-006229-7yoilsho	672	3	performed	perform	VBN
cord-006229-7yoilsho	672	4	with	with	IN
cord-006229-7yoilsho	672	5	an	an	DT
cord-006229-7yoilsho	672	6	N	n	CD
cord-006229-7yoilsho	672	7	-	-	HYPH
cord-006229-7yoilsho	672	8	terminally	terminally	RB
cord-006229-7yoilsho	672	9	tagged	tag	VBN
cord-006229-7yoilsho	672	10	receptor	receptor	NN
cord-006229-7yoilsho	672	11	immobilized	immobilize	VBN
cord-006229-7yoilsho	672	12	with	with	IN
cord-006229-7yoilsho	672	13	an	an	DT
cord-006229-7yoilsho	672	14	antibody	antibody	NN
cord-006229-7yoilsho	672	15	against	against	IN
cord-006229-7yoilsho	672	16	the	the	DT
cord-006229-7yoilsho	672	17	N	n	CD
cord-006229-7yoilsho	672	18	-	-	HYPH
cord-006229-7yoilsho	672	19	terminal	terminal	NN
cord-006229-7yoilsho	672	20	tag	tag	NN
cord-006229-7yoilsho	672	21	either	either	CC
cord-006229-7yoilsho	672	22	in	in	IN
cord-006229-7yoilsho	672	23	solution	solution	NN
cord-006229-7yoilsho	672	24	or	or	CC
cord-006229-7yoilsho	672	25	on	on	IN
cord-006229-7yoilsho	672	26	a	a	DT
cord-006229-7yoilsho	672	27	micropatterned	micropatterne	VBN
cord-006229-7yoilsho	672	28	surface	surface	NN
cord-006229-7yoilsho	672	29	.	.	.
cord-006229-7yoilsho	673	1	In	in	IN
cord-006229-7yoilsho	673	2	these	these	DT
cord-006229-7yoilsho	673	3	assays	assay	NNS
cord-006229-7yoilsho	673	4	,	,	,
cord-006229-7yoilsho	673	5	the	the	DT
cord-006229-7yoilsho	673	6	recovery	recovery	NN
cord-006229-7yoilsho	673	7	of	of	IN
cord-006229-7yoilsho	673	8	arrestin-3	arrestin-3	NN
cord-006229-7yoilsho	673	9	into	into	IN
cord-006229-7yoilsho	673	10	the	the	DT
cord-006229-7yoilsho	673	11	bleached	bleached	JJ
cord-006229-7yoilsho	673	12	region	region	NN
cord-006229-7yoilsho	673	13	was	be	VBD
cord-006229-7yoilsho	673	14	prolonged	prolong	VBN
cord-006229-7yoilsho	673	15	between	between	IN
cord-006229-7yoilsho	673	16	two	two	CD
cord-006229-7yoilsho	673	17	-	-	HYPH
cord-006229-7yoilsho	673	18	and	and	CC
cord-006229-7yoilsho	673	19	fourfold	fourfold	NN
cord-006229-7yoilsho	673	20	for	for	IN
cord-006229-7yoilsho	673	21	the	the	DT
cord-006229-7yoilsho	673	22	β	β	NN
cord-006229-7yoilsho	673	23	2	2	CD
cord-006229-7yoilsho	673	24	AR	AR	NNP
cord-006229-7yoilsho	673	25	-	-	HYPH
cord-006229-7yoilsho	673	26	SSS	SSS	NNP
cord-006229-7yoilsho	673	27	receptor	receptor	NN
cord-006229-7yoilsho	673	28	compared	compare	VBN
cord-006229-7yoilsho	673	29	to	to	IN
cord-006229-7yoilsho	673	30	the	the	DT
cord-006229-7yoilsho	673	31	wild	wild	JJ
cord-006229-7yoilsho	673	32	-	-	HYPH
cord-006229-7yoilsho	673	33	type	type	NN
cord-006229-7yoilsho	673	34	.	.	.
cord-006229-7yoilsho	674	1	Even	even	RB
cord-006229-7yoilsho	674	2	though	though	IN
cord-006229-7yoilsho	674	3	this	this	DT
cord-006229-7yoilsho	674	4	two	two	CD
cord-006229-7yoilsho	674	5	-	-	HYPH
cord-006229-7yoilsho	674	6	to	to	IN
cord-006229-7yoilsho	674	7	fourfold	fourfold	JJ
cord-006229-7yoilsho	674	8	increase	increase	NN
cord-006229-7yoilsho	674	9	in	in	IN
cord-006229-7yoilsho	674	10	affinity	affinity	NN
cord-006229-7yoilsho	674	11	seemed	seem	VBD
cord-006229-7yoilsho	674	12	rather	rather	RB
cord-006229-7yoilsho	674	13	modest	modest	JJ
cord-006229-7yoilsho	674	14	,	,	,
cord-006229-7yoilsho	674	15	it	-PRON-	PRP
cord-006229-7yoilsho	674	16	resulted	result	VBD
cord-006229-7yoilsho	674	17	in	in	IN
cord-006229-7yoilsho	674	18	the	the	DT
cord-006229-7yoilsho	674	19	trafficking	trafficking	NN
cord-006229-7yoilsho	674	20	of	of	IN
cord-006229-7yoilsho	674	21	receptorarrestin	receptorarrestin	NNS
cord-006229-7yoilsho	674	22	complexes	complex	NNS
cord-006229-7yoilsho	674	23	to	to	IN
cord-006229-7yoilsho	674	24	the	the	DT
cord-006229-7yoilsho	674	25	early	early	JJ
cord-006229-7yoilsho	674	26	endosome	endosome	NN
cord-006229-7yoilsho	674	27	whereas	whereas	IN
cord-006229-7yoilsho	674	28	the	the	DT
cord-006229-7yoilsho	674	29	wild	wild	JJ
cord-006229-7yoilsho	674	30	-	-	HYPH
cord-006229-7yoilsho	674	31	type	type	NN
cord-006229-7yoilsho	674	32	receptor	receptor	NN
cord-006229-7yoilsho	674	33	interacted	interact	VBD
cord-006229-7yoilsho	674	34	only	only	RB
cord-006229-7yoilsho	674	35	transiently	transiently	RB
cord-006229-7yoilsho	674	36	with	with	IN
cord-006229-7yoilsho	674	37	arrestin	arrestin	NNP
cord-006229-7yoilsho	674	38	at	at	IN
cord-006229-7yoilsho	674	39	the	the	DT
cord-006229-7yoilsho	674	40	plasma	plasma	NN
cord-006229-7yoilsho	674	41	membrane	membrane	NN
cord-006229-7yoilsho	674	42	.	.	.
cord-006229-7yoilsho	675	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	675	2	,	,	,
cord-006229-7yoilsho	675	3	the	the	DT
cord-006229-7yoilsho	675	4	increased	increase	VBN
cord-006229-7yoilsho	675	5	affinity	affinity	NN
cord-006229-7yoilsho	675	6	of	of	IN
cord-006229-7yoilsho	675	7	arrestin	arrestin	NN
cord-006229-7yoilsho	675	8	led	lead	VBN
cord-006229-7yoilsho	675	9	to	to	IN
cord-006229-7yoilsho	675	10	more	more	RBR
cord-006229-7yoilsho	675	11	efficient	efficient	JJ
cord-006229-7yoilsho	675	12	internalization	internalization	NN
cord-006229-7yoilsho	675	13	of	of	IN
cord-006229-7yoilsho	675	14	the	the	DT
cord-006229-7yoilsho	675	15	β	β	NN
cord-006229-7yoilsho	675	16	2	2	CD
cord-006229-7yoilsho	675	17	AR	AR	NNP
cord-006229-7yoilsho	675	18	-	-	HYPH
cord-006229-7yoilsho	675	19	SSS	SSS	NNP
cord-006229-7yoilsho	675	20	compared	compare	VBN
cord-006229-7yoilsho	675	21	to	to	IN
cord-006229-7yoilsho	675	22	the	the	DT
cord-006229-7yoilsho	675	23	wild	wild	JJ
cord-006229-7yoilsho	675	24	-	-	HYPH
cord-006229-7yoilsho	675	25	type	type	NN
cord-006229-7yoilsho	675	26	receptor	receptor	NN
cord-006229-7yoilsho	675	27	.	.	.
cord-006229-7yoilsho	676	1	However	however	RB
cord-006229-7yoilsho	676	2	,	,	,
cord-006229-7yoilsho	676	3	recycling	recycle	VBG
cord-006229-7yoilsho	676	4	to	to	IN
cord-006229-7yoilsho	676	5	the	the	DT
cord-006229-7yoilsho	676	6	plasma	plasma	NN
cord-006229-7yoilsho	676	7	membrane	membrane	NN
cord-006229-7yoilsho	676	8	after	after	IN
cord-006229-7yoilsho	676	9	agonist	agonist	NN
cord-006229-7yoilsho	676	10	washout	washout	NN
cord-006229-7yoilsho	676	11	was	be	VBD
cord-006229-7yoilsho	676	12	very	very	RB
cord-006229-7yoilsho	676	13	similar	similar	JJ
cord-006229-7yoilsho	676	14	for	for	IN
cord-006229-7yoilsho	676	15	both	both	DT
cord-006229-7yoilsho	676	16	receptors	receptor	NNS
cord-006229-7yoilsho	676	17	.	.	.
cord-006229-7yoilsho	677	1	We	-PRON-	PRP
cord-006229-7yoilsho	677	2	conclude	conclude	VBP
cord-006229-7yoilsho	677	3	that	that	IN
cord-006229-7yoilsho	677	4	even	even	RB
cord-006229-7yoilsho	677	5	a	a	DT
cord-006229-7yoilsho	677	6	modest	modest	JJ
cord-006229-7yoilsho	677	7	change	change	NN
cord-006229-7yoilsho	677	8	in	in	IN
cord-006229-7yoilsho	677	9	affinity	affinity	NN
cord-006229-7yoilsho	677	10	between	between	IN
cord-006229-7yoilsho	677	11	a	a	DT
cord-006229-7yoilsho	677	12	G	g	NN
cord-006229-7yoilsho	677	13	-	-	HYPH
cord-006229-7yoilsho	677	14	protein	protein	NN
cord-006229-7yoilsho	677	15	-	-	HYPH
cord-006229-7yoilsho	677	16	coupled	couple	VBN
cord-006229-7yoilsho	677	17	receptor	receptor	NN
cord-006229-7yoilsho	677	18	and	and	CC
cord-006229-7yoilsho	677	19	arrestin	arrestin	NN
cord-006229-7yoilsho	677	20	can	can	MD
cord-006229-7yoilsho	677	21	lead	lead	VB
cord-006229-7yoilsho	677	22	to	to	IN
cord-006229-7yoilsho	677	23	substantial	substantial	JJ
cord-006229-7yoilsho	677	24	alterations	alteration	NNS
cord-006229-7yoilsho	677	25	in	in	IN
cord-006229-7yoilsho	677	26	arrestin	arrestin	JJ
cord-006229-7yoilsho	677	27	trafficking	trafficking	NN
cord-006229-7yoilsho	677	28	which	which	WDT
cord-006229-7yoilsho	677	29	in	in	IN
cord-006229-7yoilsho	677	30	turn	turn	NN
cord-006229-7yoilsho	677	31	may	may	MD
cord-006229-7yoilsho	677	32	have	have	VB
cord-006229-7yoilsho	677	33	effects	effect	NNS
cord-006229-7yoilsho	677	34	on	on	IN
cord-006229-7yoilsho	677	35	cellular	cellular	JJ
cord-006229-7yoilsho	677	36	signaling	signaling	NN
cord-006229-7yoilsho	677	37	.	.	.
cord-006229-7yoilsho	678	1	Despite	despite	IN
cord-006229-7yoilsho	678	2	recent	recent	JJ
cord-006229-7yoilsho	678	3	structural	structural	JJ
cord-006229-7yoilsho	678	4	research	research	NN
cord-006229-7yoilsho	678	5	allow	allow	VBP
cord-006229-7yoilsho	678	6	for	for	IN
cord-006229-7yoilsho	678	7	better	well	JJR
cord-006229-7yoilsho	678	8	understanding	understanding	NN
cord-006229-7yoilsho	678	9	of	of	IN
cord-006229-7yoilsho	678	10	GPCR	GPCR	NNP
cord-006229-7yoilsho	678	11	structure	structure	NN
cord-006229-7yoilsho	678	12	,	,	,
cord-006229-7yoilsho	678	13	the	the	DT
cord-006229-7yoilsho	678	14	crucial	crucial	JJ
cord-006229-7yoilsho	678	15	aspects	aspect	NNS
cord-006229-7yoilsho	678	16	of	of	IN
cord-006229-7yoilsho	678	17	the	the	DT
cord-006229-7yoilsho	678	18	selectivity	selectivity	NN
cord-006229-7yoilsho	678	19	mechanism	mechanism	NN
cord-006229-7yoilsho	678	20	of	of	IN
cord-006229-7yoilsho	678	21	receptor	receptor	NN
cord-006229-7yoilsho	678	22	-G	-G	HYPH
cord-006229-7yoilsho	678	23	protein	protein	NN
cord-006229-7yoilsho	678	24	subtype	subtype	NN
cord-006229-7yoilsho	678	25	coupling	coupling	NN
cord-006229-7yoilsho	678	26	remain	remain	VBP
cord-006229-7yoilsho	678	27	unresolved	unresolved	JJ
cord-006229-7yoilsho	678	28	.	.	.
cord-006229-7yoilsho	679	1	Based	base	VBN
cord-006229-7yoilsho	679	2	on	on	IN
cord-006229-7yoilsho	679	3	the	the	DT
cord-006229-7yoilsho	679	4	hypothesis	hypothesis	NN
cord-006229-7yoilsho	679	5	that	that	IN
cord-006229-7yoilsho	679	6	the	the	DT
cord-006229-7yoilsho	679	7	affinity	affinity	NN
cord-006229-7yoilsho	679	8	of	of	IN
cord-006229-7yoilsho	679	9	the	the	DT
cord-006229-7yoilsho	679	10	ternary	ternary	JJ
cord-006229-7yoilsho	679	11	complex	complex	NN
cord-006229-7yoilsho	679	12	(	(	-LRB-
cord-006229-7yoilsho	679	13	agonist	agonist	NN
cord-006229-7yoilsho	679	14	/	/	SYM
cord-006229-7yoilsho	679	15	GPCR	GPCR	NNP
cord-006229-7yoilsho	679	16	/	/	SYM
cord-006229-7yoilsho	679	17	G	G	NNP
cord-006229-7yoilsho	679	18	-	-	HYPH
cord-006229-7yoilsho	679	19	Protein	Protein	NNP
cord-006229-7yoilsho	679	20	)	)	-RRB-
cord-006229-7yoilsho	679	21	in	in	IN
cord-006229-7yoilsho	679	22	the	the	DT
cord-006229-7yoilsho	679	23	nucleotide	nucleotide	JJ
cord-006229-7yoilsho	679	24	-	-	HYPH
cord-006229-7yoilsho	679	25	free	free	JJ
cord-006229-7yoilsho	679	26	state	state	NN
cord-006229-7yoilsho	679	27	determines	determine	VBZ
cord-006229-7yoilsho	679	28	the	the	DT
cord-006229-7yoilsho	679	29	selectivity	selectivity	NN
cord-006229-7yoilsho	679	30	of	of	IN
cord-006229-7yoilsho	679	31	GPCR	GPCR	NNP
cord-006229-7yoilsho	679	32	-	-	HYPH
cord-006229-7yoilsho	679	33	G	g	NN
cord-006229-7yoilsho	679	34	protein	protein	NN
cord-006229-7yoilsho	679	35	coupling	coupling	NN
cord-006229-7yoilsho	679	36	,	,	,
cord-006229-7yoilsho	679	37	we	-PRON-	PRP
cord-006229-7yoilsho	679	38	set	set	VBD
cord-006229-7yoilsho	679	39	out	out	RP
cord-006229-7yoilsho	679	40	to	to	TO
cord-006229-7yoilsho	679	41	measure	measure	VB
cord-006229-7yoilsho	679	42	GPCR	GPCR	NNP
cord-006229-7yoilsho	679	43	-	-	HYPH
cord-006229-7yoilsho	679	44	G	g	NN
cord-006229-7yoilsho	679	45	protein	protein	NN
cord-006229-7yoilsho	679	46	interaction	interaction	NN
cord-006229-7yoilsho	679	47	in	in	IN
cord-006229-7yoilsho	679	48	membranes	membrane	NNS
cord-006229-7yoilsho	679	49	of	of	IN
cord-006229-7yoilsho	679	50	single	single	JJ
cord-006229-7yoilsho	679	51	cells	cell	NNS
cord-006229-7yoilsho	679	52	.	.	.
cord-006229-7yoilsho	680	1	In	in	IN
cord-006229-7yoilsho	680	2	order	order	NN
cord-006229-7yoilsho	680	3	to	to	TO
cord-006229-7yoilsho	680	4	quantify	quantify	VB
cord-006229-7yoilsho	680	5	the	the	DT
cord-006229-7yoilsho	680	6	affinity	affinity	NN
cord-006229-7yoilsho	680	7	of	of	IN
cord-006229-7yoilsho	680	8	Gα	Gα	NNP
cord-006229-7yoilsho	680	9	-	-	HYPH
cord-006229-7yoilsho	680	10	subunit	subunit	NN
cord-006229-7yoilsho	680	11	towards	towards	IN
cord-006229-7yoilsho	680	12	GPCRs	gpcr	NNS
cord-006229-7yoilsho	680	13	in	in	IN
cord-006229-7yoilsho	680	14	single	single	JJ
cord-006229-7yoilsho	680	15	cell	cell	NN
cord-006229-7yoilsho	680	16	,	,	,
cord-006229-7yoilsho	680	17	we	-PRON-	PRP
cord-006229-7yoilsho	680	18	determined	determine	VBD
cord-006229-7yoilsho	680	19	the	the	DT
cord-006229-7yoilsho	680	20	lifetime	lifetime	NN
cord-006229-7yoilsho	680	21	of	of	IN
cord-006229-7yoilsho	680	22	the	the	DT
cord-006229-7yoilsho	680	23	receptor	receptor	NN
cord-006229-7yoilsho	680	24	-	-	HYPH
cord-006229-7yoilsho	680	25	G	g	NN
cord-006229-7yoilsho	680	26	protein	protein	NN
cord-006229-7yoilsho	680	27	complex	complex	NN
cord-006229-7yoilsho	680	28	in	in	IN
cord-006229-7yoilsho	680	29	living	live	VBG
cord-006229-7yoilsho	680	30	cells	cell	NNS
cord-006229-7yoilsho	680	31	upon	upon	IN
cord-006229-7yoilsho	680	32	agonist	agonist	NN
cord-006229-7yoilsho	680	33	withdrawal	withdrawal	NN
cord-006229-7yoilsho	680	34	under	under	IN
cord-006229-7yoilsho	680	35	conditions	condition	NNS
cord-006229-7yoilsho	680	36	of	of	IN
cord-006229-7yoilsho	680	37	GTP	gtp	NN
cord-006229-7yoilsho	680	38	-	-	HYPH
cord-006229-7yoilsho	680	39	depletion	depletion	NN
cord-006229-7yoilsho	680	40	.	.	.
cord-006229-7yoilsho	681	1	Therefore	therefore	RB
cord-006229-7yoilsho	681	2	,	,	,
cord-006229-7yoilsho	681	3	we	-PRON-	PRP
cord-006229-7yoilsho	681	4	utilized	utilize	VBD
cord-006229-7yoilsho	681	5	Förster	Förster	NNP
cord-006229-7yoilsho	681	6	resonance	resonance	NN
cord-006229-7yoilsho	681	7	energy	energy	NN
cord-006229-7yoilsho	681	8	transfer	transfer	NN
cord-006229-7yoilsho	681	9	(	(	-LRB-
cord-006229-7yoilsho	681	10	FRET	fret	NN
cord-006229-7yoilsho	681	11	)	)	-RRB-
cord-006229-7yoilsho	681	12	based	base	VBN
cord-006229-7yoilsho	681	13	assays	assay	NNS
cord-006229-7yoilsho	681	14	to	to	TO
cord-006229-7yoilsho	681	15	study	study	VB
cord-006229-7yoilsho	681	16	interactions	interaction	NNS
cord-006229-7yoilsho	681	17	between	between	IN
cord-006229-7yoilsho	681	18	fluorescent	fluorescent	JJ
cord-006229-7yoilsho	681	19	muscarinic	muscarinic	JJ
cord-006229-7yoilsho	681	20	receptors	receptor	NNS
cord-006229-7yoilsho	681	21	and	and	CC
cord-006229-7yoilsho	681	22	heterotrimeric	heterotrimeric	NNP
cord-006229-7yoilsho	681	23	G	g	NN
cord-006229-7yoilsho	681	24	proteins	protein	NNS
cord-006229-7yoilsho	681	25	in	in	IN
cord-006229-7yoilsho	681	26	single	single	JJ
cord-006229-7yoilsho	681	27	permeabilized	permeabilized	JJ
cord-006229-7yoilsho	681	28	HEK293	HEK293	NNP
cord-006229-7yoilsho	681	29	T	t	NN
cord-006229-7yoilsho	681	30	cells	cell	NNS
cord-006229-7yoilsho	681	31	transfected	transfecte	VBN
cord-006229-7yoilsho	681	32	with	with	IN
cord-006229-7yoilsho	681	33	the	the	DT
cord-006229-7yoilsho	681	34	appropriate	appropriate	JJ
cord-006229-7yoilsho	681	35	cDNAs	cdna	NNS
cord-006229-7yoilsho	681	36	.	.	.
cord-006229-7yoilsho	682	1	Here	here	RB
cord-006229-7yoilsho	682	2	we	-PRON-	PRP
cord-006229-7yoilsho	682	3	focused	focus	VBD
cord-006229-7yoilsho	682	4	on	on	IN
cord-006229-7yoilsho	682	5	muscarinic	muscarinic	JJ
cord-006229-7yoilsho	682	6	M1-	M1-	NNP
cord-006229-7yoilsho	682	7	,	,	,
cord-006229-7yoilsho	682	8	M2-	M2-	NNP
cord-006229-7yoilsho	682	9	,	,	,
cord-006229-7yoilsho	682	10	and	and	CC
cord-006229-7yoilsho	682	11	M3-receptors	m3-receptor	NNS
cord-006229-7yoilsho	682	12	and	and	CC
cord-006229-7yoilsho	682	13	characterized	characterize	VBD
cord-006229-7yoilsho	682	14	the	the	DT
cord-006229-7yoilsho	682	15	kinetics	kinetic	NNS
cord-006229-7yoilsho	682	16	of	of	IN
cord-006229-7yoilsho	682	17	agonist	agonist	NN
cord-006229-7yoilsho	682	18	-	-	HYPH
cord-006229-7yoilsho	682	19	induced	induce	VBN
cord-006229-7yoilsho	682	20	binding	binding	NN
cord-006229-7yoilsho	682	21	of	of	IN
cord-006229-7yoilsho	682	22	Go	Go	NNP
cord-006229-7yoilsho	682	23	/	/	SYM
cord-006229-7yoilsho	682	24	i	i	NN
cord-006229-7yoilsho	682	25	-and	-and	:
cord-006229-7yoilsho	682	26	Gq/11-proteins	gq/11-protein	NNS
cord-006229-7yoilsho	682	27	to	to	IN
cord-006229-7yoilsho	682	28	muscarinic	muscarinic	JJ
cord-006229-7yoilsho	682	29	receptors	receptor	NNS
cord-006229-7yoilsho	682	30	and	and	CC
cord-006229-7yoilsho	682	31	their	-PRON-	PRP$
cord-006229-7yoilsho	682	32	subsequent	subsequent	JJ
cord-006229-7yoilsho	682	33	dissociation	dissociation	NN
cord-006229-7yoilsho	682	34	in	in	IN
cord-006229-7yoilsho	682	35	the	the	DT
cord-006229-7yoilsho	682	36	absence	absence	NN
cord-006229-7yoilsho	682	37	of	of	IN
cord-006229-7yoilsho	682	38	nucleotides	nucleotide	NNS
cord-006229-7yoilsho	682	39	.	.	.
cord-006229-7yoilsho	683	1	As	as	IN
cord-006229-7yoilsho	683	2	a	a	DT
cord-006229-7yoilsho	683	3	measure	measure	NN
cord-006229-7yoilsho	683	4	of	of	IN
cord-006229-7yoilsho	683	5	affinity	affinity	NN
cord-006229-7yoilsho	683	6	we	-PRON-	PRP
cord-006229-7yoilsho	683	7	calculated	calculate	VBD
cord-006229-7yoilsho	683	8	the	the	DT
cord-006229-7yoilsho	683	9	rate	rate	NN
cord-006229-7yoilsho	683	10	constant	constant	NN
cord-006229-7yoilsho	683	11	of	of	IN
cord-006229-7yoilsho	683	12	G	g	NN
cord-006229-7yoilsho	683	13	protein	protein	NN
cord-006229-7yoilsho	683	14	dissociation	dissociation	NN
cord-006229-7yoilsho	683	15	from	from	IN
cord-006229-7yoilsho	683	16	the	the	DT
cord-006229-7yoilsho	683	17	receptor	receptor	NN
cord-006229-7yoilsho	683	18	after	after	IN
cord-006229-7yoilsho	683	19	agonist	agonist	NN
cord-006229-7yoilsho	683	20	withdrawal	withdrawal	NN
cord-006229-7yoilsho	683	21	.	.	.
cord-006229-7yoilsho	684	1	The	the	DT
cord-006229-7yoilsho	684	2	dissociation	dissociation	NN
cord-006229-7yoilsho	684	3	kinetics	kinetics	NN
cord-006229-7yoilsho	684	4	of	of	IN
cord-006229-7yoilsho	684	5	Go	go	VB
cord-006229-7yoilsho	684	6	protein	protein	NN
cord-006229-7yoilsho	684	7	from	from	IN
cord-006229-7yoilsho	684	8	M3-and	m3-and	NN
cord-006229-7yoilsho	684	9	M1-AChRs	M1-AChRs	NNP
cord-006229-7yoilsho	684	10	was	be	VBD
cord-006229-7yoilsho	684	11	found	find	VBN
cord-006229-7yoilsho	684	12	to	to	TO
cord-006229-7yoilsho	684	13	be	be	VB
cord-006229-7yoilsho	684	14	10-fold	10-fold	JJ
cord-006229-7yoilsho	684	15	faster	fast	RBR
cord-006229-7yoilsho	684	16	in	in	IN
cord-006229-7yoilsho	684	17	comparison	comparison	NN
cord-006229-7yoilsho	684	18	to	to	IN
cord-006229-7yoilsho	684	19	Gq	Gq	NNP
cord-006229-7yoilsho	684	20	.	.	.
cord-006229-7yoilsho	685	1	Similarly	similarly	RB
cord-006229-7yoilsho	685	2	,	,	,
cord-006229-7yoilsho	685	3	we	-PRON-	PRP
cord-006229-7yoilsho	685	4	observed	observe	VBD
cord-006229-7yoilsho	685	5	a	a	DT
cord-006229-7yoilsho	685	6	15-fold	15-fold	JJ
cord-006229-7yoilsho	685	7	right	right	JJ
cord-006229-7yoilsho	685	8	shift	shift	NN
cord-006229-7yoilsho	685	9	of	of	IN
cord-006229-7yoilsho	685	10	the	the	DT
cord-006229-7yoilsho	685	11	concentration	concentration	NN
cord-006229-7yoilsho	685	12	-	-	HYPH
cord-006229-7yoilsho	685	13	response	response	NN
cord-006229-7yoilsho	685	14	curves	curve	NNS
cord-006229-7yoilsho	685	15	of	of	IN
cord-006229-7yoilsho	685	16	Go	Go	NNP
cord-006229-7yoilsho	685	17	proteins	protein	NNS
cord-006229-7yoilsho	685	18	binding	bind	VBG
cord-006229-7yoilsho	685	19	to	to	IN
cord-006229-7yoilsho	685	20	M3-AChR	M3-AChR	NNP
cord-006229-7yoilsho	685	21	in	in	IN
cord-006229-7yoilsho	685	22	comparison	comparison	NN
cord-006229-7yoilsho	685	23	to	to	IN
cord-006229-7yoilsho	685	24	Gq	Gq	NNP
cord-006229-7yoilsho	685	25	.	.	.
cord-006229-7yoilsho	686	1	In	in	IN
cord-006229-7yoilsho	686	2	order	order	NN
cord-006229-7yoilsho	686	3	to	to	TO
cord-006229-7yoilsho	686	4	ensure	ensure	VB
cord-006229-7yoilsho	686	5	,	,	,
cord-006229-7yoilsho	686	6	that	that	IN
cord-006229-7yoilsho	686	7	the	the	DT
cord-006229-7yoilsho	686	8	affinity	affinity	NN
cord-006229-7yoilsho	686	9	of	of	IN
cord-006229-7yoilsho	686	10	the	the	DT
cord-006229-7yoilsho	686	11	ternary	ternary	JJ
cord-006229-7yoilsho	686	12	complex	complex	NN
cord-006229-7yoilsho	686	13	correlates	correlate	VBZ
cord-006229-7yoilsho	686	14	with	with	IN
cord-006229-7yoilsho	686	15	the	the	DT
cord-006229-7yoilsho	686	16	efficiency	efficiency	NN
cord-006229-7yoilsho	686	17	of	of	IN
cord-006229-7yoilsho	686	18	G	g	NN
cord-006229-7yoilsho	686	19	protein	protein	NN
cord-006229-7yoilsho	686	20	activation	activation	NN
cord-006229-7yoilsho	686	21	,	,	,
cord-006229-7yoilsho	686	22	we	-PRON-	PRP
cord-006229-7yoilsho	686	23	performed	perform	VBD
cord-006229-7yoilsho	686	24	experiments	experiment	NNS
cord-006229-7yoilsho	686	25	on	on	IN
cord-006229-7yoilsho	686	26	the	the	DT
cord-006229-7yoilsho	686	27	G	g	NN
cord-006229-7yoilsho	686	28	protein	protein	NN
cord-006229-7yoilsho	686	29	activity	activity	NN
cord-006229-7yoilsho	686	30	in	in	IN
cord-006229-7yoilsho	686	31	intact	intact	JJ
cord-006229-7yoilsho	686	32	cells	cell	NNS
cord-006229-7yoilsho	686	33	expressing	express	VBG
cord-006229-7yoilsho	686	34	non	non	JJ
cord-006229-7yoilsho	686	35	-	-	JJ
cord-006229-7yoilsho	686	36	fluorescent	fluorescent	JJ
cord-006229-7yoilsho	686	37	M3-AChR	M3-AChR	NNP
cord-006229-7yoilsho	686	38	by	by	IN
cord-006229-7yoilsho	686	39	using	use	VBG
cord-006229-7yoilsho	686	40	a	a	DT
cord-006229-7yoilsho	686	41	FRET	fret	NN
cord-006229-7yoilsho	686	42	-	-	HYPH
cord-006229-7yoilsho	686	43	based	base	VBN
cord-006229-7yoilsho	686	44	assay	assay	NN
cord-006229-7yoilsho	686	45	.	.	.
cord-006229-7yoilsho	687	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	687	2	results	result	NNS
cord-006229-7yoilsho	687	3	showed	show	VBD
cord-006229-7yoilsho	687	4	that	that	IN
cord-006229-7yoilsho	687	5	Gq	Gq	NNP
cord-006229-7yoilsho	687	6	activation	activation	NN
cord-006229-7yoilsho	687	7	required	require	VBD
cord-006229-7yoilsho	687	8	10-fold	10-fold	CD
cord-006229-7yoilsho	687	9	lower	low	JJR
cord-006229-7yoilsho	687	10	agonist	agonist	NN
cord-006229-7yoilsho	687	11	concentration	concentration	NN
cord-006229-7yoilsho	687	12	compared	compare	VBN
cord-006229-7yoilsho	687	13	to	to	TO
cord-006229-7yoilsho	687	14	Go	go	VB
cord-006229-7yoilsho	687	15	activation	activation	NN
cord-006229-7yoilsho	687	16	,	,	,
cord-006229-7yoilsho	687	17	suggesting	suggest	VBG
cord-006229-7yoilsho	687	18	that	that	IN
cord-006229-7yoilsho	687	19	indeed	indeed	RB
cord-006229-7yoilsho	687	20	the	the	DT
cord-006229-7yoilsho	687	21	stability	stability	NN
cord-006229-7yoilsho	687	22	of	of	IN
cord-006229-7yoilsho	687	23	the	the	DT
cord-006229-7yoilsho	687	24	ternary	ternary	JJ
cord-006229-7yoilsho	687	25	complex	complex	NN
cord-006229-7yoilsho	687	26	in	in	IN
cord-006229-7yoilsho	687	27	the	the	DT
cord-006229-7yoilsho	687	28	absence	absence	NN
cord-006229-7yoilsho	687	29	of	of	IN
cord-006229-7yoilsho	687	30	nucleotides	nucleotide	NNS
cord-006229-7yoilsho	687	31	determines	determine	VBZ
cord-006229-7yoilsho	687	32	the	the	DT
cord-006229-7yoilsho	687	33	selectivity	selectivity	NN
cord-006229-7yoilsho	687	34	of	of	IN
cord-006229-7yoilsho	687	35	GPCR	GPCR	NNP
cord-006229-7yoilsho	687	36	-	-	HYPH
cord-006229-7yoilsho	687	37	G	g	NN
cord-006229-7yoilsho	687	38	protein	protein	NN
cord-006229-7yoilsho	687	39	coupling	coupling	NN
cord-006229-7yoilsho	687	40	.	.	.
cord-006229-7yoilsho	688	1	We	-PRON-	PRP
cord-006229-7yoilsho	688	2	further	further	RB
cord-006229-7yoilsho	688	3	explored	explore	VBD
cord-006229-7yoilsho	688	4	the	the	DT
cord-006229-7yoilsho	688	5	subtype	subtype	NN
cord-006229-7yoilsho	688	6	selectivity	selectivity	NN
cord-006229-7yoilsho	688	7	of	of	IN
cord-006229-7yoilsho	688	8	M2-AChR	M2-AChR	NNP
cord-006229-7yoilsho	688	9	for	for	IN
cord-006229-7yoilsho	688	10	Gi	Gi	NNP
cord-006229-7yoilsho	688	11	family	family	NN
cord-006229-7yoilsho	688	12	members	member	NNS
cord-006229-7yoilsho	688	13	by	by	IN
cord-006229-7yoilsho	688	14	comparison	comparison	NN
cord-006229-7yoilsho	688	15	of	of	IN
cord-006229-7yoilsho	688	16	dissociation	dissociation	NN
cord-006229-7yoilsho	688	17	kinetics	kinetic	NNS
cord-006229-7yoilsho	688	18	of	of	IN
cord-006229-7yoilsho	688	19	Gi1-	Gi1-	NNP
cord-006229-7yoilsho	688	20	,	,	,
cord-006229-7yoilsho	688	21	Gi2	gi2	CD
cord-006229-7yoilsho	688	22	,	,	,
cord-006229-7yoilsho	688	23	Gi3-	Gi3-	NNP
cord-006229-7yoilsho	688	24	,	,	,
cord-006229-7yoilsho	688	25	and	and	CC
cord-006229-7yoilsho	688	26	Go	go	VB
cord-006229-7yoilsho	688	27	-	-	HYPH
cord-006229-7yoilsho	688	28	proteins	protein	NNS
cord-006229-7yoilsho	688	29	from	from	IN
cord-006229-7yoilsho	688	30	M2-AChR	M2-AChR	NNP
cord-006229-7yoilsho	688	31	under	under	IN
cord-006229-7yoilsho	688	32	nucleotide	nucleotide	JJ
cord-006229-7yoilsho	688	33	depleted	deplete	VBN
cord-006229-7yoilsho	688	34	conditions	condition	NNS
cord-006229-7yoilsho	688	35	.	.	.
cord-006229-7yoilsho	689	1	K	K	NNP
cord-006229-7yoilsho	689	2	off	off	IN
cord-006229-7yoilsho	689	3	of	of	IN
cord-006229-7yoilsho	689	4	Gi1	gi1	NN
cord-006229-7yoilsho	689	5	and	and	CC
cord-006229-7yoilsho	689	6	Gi3	gi3	NN
cord-006229-7yoilsho	689	7	were	be	VBD
cord-006229-7yoilsho	689	8	found	find	VBN
cord-006229-7yoilsho	689	9	to	to	TO
cord-006229-7yoilsho	689	10	be	be	VB
cord-006229-7yoilsho	689	11	two	two	CD
cord-006229-7yoilsho	689	12	-	-	:
cord-006229-7yoilsho	689	13	fold	fold	VB
cord-006229-7yoilsho	689	14	higher	higher	RBR
cord-006229-7yoilsho	689	15	in	in	IN
cord-006229-7yoilsho	689	16	comparison	comparison	NN
cord-006229-7yoilsho	689	17	to	to	IN
cord-006229-7yoilsho	689	18	Gi2	gi2	NN
cord-006229-7yoilsho	689	19	and	and	CC
cord-006229-7yoilsho	689	20	Go	go	VB
cord-006229-7yoilsho	689	21	proteins	protein	NNS
cord-006229-7yoilsho	689	22	,	,	,
cord-006229-7yoilsho	689	23	indicating	indicate	VBG
cord-006229-7yoilsho	689	24	the	the	DT
cord-006229-7yoilsho	689	25	higher	high	JJR
cord-006229-7yoilsho	689	26	affinity	affinity	NN
cord-006229-7yoilsho	689	27	of	of	IN
cord-006229-7yoilsho	689	28	the	the	DT
cord-006229-7yoilsho	689	29	latter	latter	JJ
cord-006229-7yoilsho	689	30	ones	one	NNS
cord-006229-7yoilsho	689	31	to	to	TO
cord-006229-7yoilsho	689	32	M2-AChR.	m2-achr.	VB
cord-006229-7yoilsho	690	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	690	2	FRET	fret	NN
cord-006229-7yoilsho	690	3	-	-	HYPH
cord-006229-7yoilsho	690	4	based	base	VBN
cord-006229-7yoilsho	690	5	assay	assay	NN
cord-006229-7yoilsho	690	6	to	to	TO
cord-006229-7yoilsho	690	7	study	study	VB
cord-006229-7yoilsho	690	8	receptor	receptor	NN
cord-006229-7yoilsho	690	9	-	-	HYPH
cord-006229-7yoilsho	690	10	G	g	NN
cord-006229-7yoilsho	690	11	-	-	HYPH
cord-006229-7yoilsho	690	12	protein	protein	NN
cord-006229-7yoilsho	690	13	interactions	interaction	NNS
cord-006229-7yoilsho	690	14	in	in	IN
cord-006229-7yoilsho	690	15	membranes	membrane	NNS
cord-006229-7yoilsho	690	16	of	of	IN
cord-006229-7yoilsho	690	17	single	single	JJ
cord-006229-7yoilsho	690	18	cells	cell	NNS
cord-006229-7yoilsho	690	19	has	have	VBZ
cord-006229-7yoilsho	690	20	been	be	VBN
cord-006229-7yoilsho	690	21	proven	prove	VBN
cord-006229-7yoilsho	690	22	to	to	TO
cord-006229-7yoilsho	690	23	be	be	VB
cord-006229-7yoilsho	690	24	a	a	DT
cord-006229-7yoilsho	690	25	fast	fast	JJ
cord-006229-7yoilsho	690	26	and	and	CC
cord-006229-7yoilsho	690	27	reliable	reliable	JJ
cord-006229-7yoilsho	690	28	method	method	NN
cord-006229-7yoilsho	690	29	to	to	TO
cord-006229-7yoilsho	690	30	quantify	quantify	VB
cord-006229-7yoilsho	690	31	the	the	DT
cord-006229-7yoilsho	690	32	affinity	affinity	NN
cord-006229-7yoilsho	690	33	of	of	IN
cord-006229-7yoilsho	690	34	the	the	DT
cord-006229-7yoilsho	690	35	ternary	ternary	JJ
cord-006229-7yoilsho	690	36	complex	complex	NN
cord-006229-7yoilsho	690	37	.	.	.
cord-006229-7yoilsho	691	1	The	the	DT
cord-006229-7yoilsho	691	2	G	g	NN
cord-006229-7yoilsho	691	3	protein	protein	NN
cord-006229-7yoilsho	691	4	subtype	subtype	NN
cord-006229-7yoilsho	691	5	dependent	dependent	JJ
cord-006229-7yoilsho	691	6	differences	difference	NNS
cord-006229-7yoilsho	691	7	in	in	IN
cord-006229-7yoilsho	691	8	the	the	DT
cord-006229-7yoilsho	691	9	affinity	affinity	NN
cord-006229-7yoilsho	691	10	towards	towards	IN
cord-006229-7yoilsho	691	11	activated	activate	VBN
cord-006229-7yoilsho	691	12	receptors	receptor	NNS
cord-006229-7yoilsho	691	13	correlate	correlate	VBP
cord-006229-7yoilsho	691	14	with	with	IN
cord-006229-7yoilsho	691	15	the	the	DT
cord-006229-7yoilsho	691	16	G	g	NN
cord-006229-7yoilsho	691	17	protein	protein	NN
cord-006229-7yoilsho	691	18	coupling	coupling	NN
cord-006229-7yoilsho	691	19	efficiency	efficiency	NN
cord-006229-7yoilsho	691	20	of	of	IN
cord-006229-7yoilsho	691	21	this	this	DT
cord-006229-7yoilsho	691	22	receptor	receptor	NN
cord-006229-7yoilsho	691	23	.	.	.
cord-006229-7yoilsho	692	1	Despite	despite	IN
cord-006229-7yoilsho	692	2	their	-PRON-	PRP$
cord-006229-7yoilsho	692	3	tremendous	tremendous	JJ
cord-006229-7yoilsho	692	4	pharmacological	pharmacological	JJ
cord-006229-7yoilsho	692	5	relevance	relevance	NN
cord-006229-7yoilsho	692	6	and	and	CC
cord-006229-7yoilsho	692	7	potential	potential	NN
cord-006229-7yoilsho	692	8	for	for	IN
cord-006229-7yoilsho	692	9	the	the	DT
cord-006229-7yoilsho	692	10	development	development	NN
cord-006229-7yoilsho	692	11	of	of	IN
cord-006229-7yoilsho	692	12	new	new	JJ
cord-006229-7yoilsho	692	13	drugs	drug	NNS
cord-006229-7yoilsho	692	14	,	,	,
cord-006229-7yoilsho	692	15	our	-PRON-	PRP$
cord-006229-7yoilsho	692	16	understanding	understanding	NN
cord-006229-7yoilsho	692	17	of	of	IN
cord-006229-7yoilsho	692	18	G	g	NN
cord-006229-7yoilsho	692	19	protein	protein	NN
cord-006229-7yoilsho	692	20	-	-	HYPH
cord-006229-7yoilsho	692	21	coupled	couple	VBN
cord-006229-7yoilsho	692	22	receptor	receptor	NN
cord-006229-7yoilsho	692	23	(	(	-LRB-
cord-006229-7yoilsho	692	24	GPCR	GPCR	NNP
cord-006229-7yoilsho	692	25	)	)	-RRB-
cord-006229-7yoilsho	692	26	architecture	architecture	NN
cord-006229-7yoilsho	692	27	and	and	CC
cord-006229-7yoilsho	692	28	signaling	signaling	NN
cord-006229-7yoilsho	692	29	mechanisms	mechanism	NNS
cord-006229-7yoilsho	692	30	are	be	VBP
cord-006229-7yoilsho	692	31	still	still	RB
cord-006229-7yoilsho	692	32	limited	limited	JJ
cord-006229-7yoilsho	692	33	.	.	.
cord-006229-7yoilsho	693	1	Major	major	JJ
cord-006229-7yoilsho	693	2	reasons	reason	NNS
cord-006229-7yoilsho	693	3	for	for	IN
cord-006229-7yoilsho	693	4	this	this	DT
cord-006229-7yoilsho	693	5	are	be	VBP
cord-006229-7yoilsho	693	6	the	the	DT
cord-006229-7yoilsho	693	7	low	low	JJ
cord-006229-7yoilsho	693	8	abundance	abundance	NN
cord-006229-7yoilsho	693	9	and	and	CC
cord-006229-7yoilsho	693	10	poor	poor	JJ
cord-006229-7yoilsho	693	11	biophysical	biophysical	JJ
cord-006229-7yoilsho	693	12	properties	property	NNS
cord-006229-7yoilsho	693	13	of	of	IN
cord-006229-7yoilsho	693	14	GPCRs	gpcr	NNS
cord-006229-7yoilsho	693	15	,	,	,
cord-006229-7yoilsho	693	16	which	which	WDT
cord-006229-7yoilsho	693	17	makes	make	VBZ
cord-006229-7yoilsho	693	18	them	-PRON-	PRP
cord-006229-7yoilsho	693	19	one	one	CD
cord-006229-7yoilsho	693	20	of	of	IN
cord-006229-7yoilsho	693	21	the	the	DT
cord-006229-7yoilsho	693	22	most	most	RBS
cord-006229-7yoilsho	693	23	challenging	challenging	JJ
cord-006229-7yoilsho	693	24	class	class	NN
cord-006229-7yoilsho	693	25	of	of	IN
cord-006229-7yoilsho	693	26	proteins	protein	NNS
cord-006229-7yoilsho	693	27	for	for	IN
cord-006229-7yoilsho	693	28	structural	structural	JJ
cord-006229-7yoilsho	693	29	and	and	CC
cord-006229-7yoilsho	693	30	biophysical	biophysical	JJ
cord-006229-7yoilsho	693	31	studies	study	NNS
cord-006229-7yoilsho	693	32	.	.	.
cord-006229-7yoilsho	694	1	Among	among	IN
cord-006229-7yoilsho	694	2	the	the	DT
cord-006229-7yoilsho	694	3	superfamily	superfamily	NN
cord-006229-7yoilsho	694	4	of	of	IN
cord-006229-7yoilsho	694	5	GPCRs	gpcr	NNS
cord-006229-7yoilsho	694	6	,	,	,
cord-006229-7yoilsho	694	7	the	the	DT
cord-006229-7yoilsho	694	8	class	class	NN
cord-006229-7yoilsho	694	9	B	b	NN
cord-006229-7yoilsho	694	10	receptors	receptor	NNS
cord-006229-7yoilsho	694	11	comprising	comprise	VBG
cord-006229-7yoilsho	694	12	15	15	CD
cord-006229-7yoilsho	694	13	receptors	receptor	NNS
cord-006229-7yoilsho	694	14	are	be	VBP
cord-006229-7yoilsho	694	15	structurally	structurally	RB
cord-006229-7yoilsho	694	16	least	least	JJS
cord-006229-7yoilsho	694	17	understood	understand	VBN
cord-006229-7yoilsho	694	18	because	because	IN
cord-006229-7yoilsho	694	19	to	to	IN
cord-006229-7yoilsho	694	20	date	date	NN
cord-006229-7yoilsho	694	21	it	-PRON-	PRP
cord-006229-7yoilsho	694	22	has	have	VBZ
cord-006229-7yoilsho	694	23	not	not	RB
cord-006229-7yoilsho	694	24	been	be	VBN
cord-006229-7yoilsho	694	25	possible	possible	JJ
cord-006229-7yoilsho	694	26	to	to	TO
cord-006229-7yoilsho	694	27	obtain	obtain	VB
cord-006229-7yoilsho	694	28	a	a	DT
cord-006229-7yoilsho	694	29	crystal	crystal	JJ
cord-006229-7yoilsho	694	30	structure	structure	NN
cord-006229-7yoilsho	694	31	of	of	IN
cord-006229-7yoilsho	694	32	this	this	DT
cord-006229-7yoilsho	694	33	receptor	receptor	NN
cord-006229-7yoilsho	694	34	class	class	NN
cord-006229-7yoilsho	694	35	.	.	.
cord-006229-7yoilsho	695	1	To	to	TO
cord-006229-7yoilsho	695	2	overcome	overcome	VB
cord-006229-7yoilsho	695	3	these	these	DT
cord-006229-7yoilsho	695	4	limitations	limitation	NNS
cord-006229-7yoilsho	695	5	,	,	,
cord-006229-7yoilsho	695	6	we	-PRON-	PRP
cord-006229-7yoilsho	695	7	have	have	VBP
cord-006229-7yoilsho	695	8	developed	develop	VBN
cord-006229-7yoilsho	695	9	a	a	DT
cord-006229-7yoilsho	695	10	method	method	NN
cord-006229-7yoilsho	695	11	for	for	IN
cord-006229-7yoilsho	695	12	improving	improve	VBG
cord-006229-7yoilsho	695	13	functional	functional	JJ
cord-006229-7yoilsho	695	14	expression	expression	NN
cord-006229-7yoilsho	695	15	and	and	CC
cord-006229-7yoilsho	695	16	simultaneous	simultaneous	JJ
cord-006229-7yoilsho	695	17	thermo	thermo	NN
cord-006229-7yoilsho	695	18	-	-	HYPH
cord-006229-7yoilsho	695	19	stabilization	stabilization	NN
cord-006229-7yoilsho	695	20	of	of	IN
cord-006229-7yoilsho	695	21	GPCRs	gpcr	NNS
cord-006229-7yoilsho	695	22	by	by	IN
cord-006229-7yoilsho	695	23	directed	direct	VBN
cord-006229-7yoilsho	695	24	evolution	evolution	NN
cord-006229-7yoilsho	695	25	which	which	WDT
cord-006229-7yoilsho	695	26	is	be	VBZ
cord-006229-7yoilsho	695	27	based	base	VBN
cord-006229-7yoilsho	695	28	on	on	IN
cord-006229-7yoilsho	695	29	expression	expression	NN
cord-006229-7yoilsho	695	30	of	of	IN
cord-006229-7yoilsho	695	31	receptors	receptor	NNS
cord-006229-7yoilsho	695	32	in	in	IN
cord-006229-7yoilsho	695	33	Saccharomyces	Saccharomyces	NNP
cord-006229-7yoilsho	695	34	cerevisiae	cerevisiae	NNS
cord-006229-7yoilsho	695	35	and	and	CC
cord-006229-7yoilsho	695	36	subsequent	subsequent	JJ
cord-006229-7yoilsho	695	37	selection	selection	NN
cord-006229-7yoilsho	695	38	of	of	IN
cord-006229-7yoilsho	695	39	highly	highly	RB
cord-006229-7yoilsho	695	40	expressing	express	VBG
cord-006229-7yoilsho	695	41	variants	variant	NNS
cord-006229-7yoilsho	695	42	by	by	IN
cord-006229-7yoilsho	695	43	flow	flow	NN
cord-006229-7yoilsho	695	44	cytometry	cytometry	NN
cord-006229-7yoilsho	695	45	with	with	IN
cord-006229-7yoilsho	695	46	fluorescent	fluorescent	JJ
cord-006229-7yoilsho	695	47	ligands	ligand	NNS
cord-006229-7yoilsho	695	48	.	.	.
cord-006229-7yoilsho	696	1	By	by	IN
cord-006229-7yoilsho	696	2	this	this	DT
cord-006229-7yoilsho	696	3	strategy	strategy	NN
cord-006229-7yoilsho	696	4	,	,	,
cord-006229-7yoilsho	696	5	key	key	JJ
cord-006229-7yoilsho	696	6	residues	residue	NNS
cord-006229-7yoilsho	696	7	within	within	IN
cord-006229-7yoilsho	696	8	a	a	DT
cord-006229-7yoilsho	696	9	receptor	receptor	NN
cord-006229-7yoilsho	696	10	sequence	sequence	NN
cord-006229-7yoilsho	696	11	can	can	MD
cord-006229-7yoilsho	696	12	be	be	VB
cord-006229-7yoilsho	696	13	rapidly	rapidly	RB
cord-006229-7yoilsho	696	14	identified	identify	VBN
cord-006229-7yoilsho	696	15	that	that	WDT
cord-006229-7yoilsho	696	16	are	be	VBP
cord-006229-7yoilsho	696	17	responsible	responsible	JJ
cord-006229-7yoilsho	696	18	for	for	IN
cord-006229-7yoilsho	696	19	improved	improve	VBN
cord-006229-7yoilsho	696	20	biophysical	biophysical	JJ
cord-006229-7yoilsho	696	21	properties	property	NNS
cord-006229-7yoilsho	696	22	without	without	IN
cord-006229-7yoilsho	696	23	greatly	greatly	RB
cord-006229-7yoilsho	696	24	affecting	affect	VBG
cord-006229-7yoilsho	696	25	the	the	DT
cord-006229-7yoilsho	696	26	pharmacological	pharmacological	JJ
cord-006229-7yoilsho	696	27	features	feature	NNS
cord-006229-7yoilsho	696	28	of	of	IN
cord-006229-7yoilsho	696	29	the	the	DT
cord-006229-7yoilsho	696	30	receptor	receptor	NN
cord-006229-7yoilsho	696	31	.	.	.
cord-006229-7yoilsho	697	1	We	-PRON-	PRP
cord-006229-7yoilsho	697	2	have	have	VBP
cord-006229-7yoilsho	697	3	now	now	RB
cord-006229-7yoilsho	697	4	applied	apply	VBN
cord-006229-7yoilsho	697	5	this	this	DT
cord-006229-7yoilsho	697	6	method	method	NN
cord-006229-7yoilsho	697	7	to	to	IN
cord-006229-7yoilsho	697	8	the	the	DT
cord-006229-7yoilsho	697	9	human	human	JJ
cord-006229-7yoilsho	697	10	parathyroid	parathyroid	JJ
cord-006229-7yoilsho	697	11	hormone	hormone	NN
cord-006229-7yoilsho	697	12	1	1	CD
cord-006229-7yoilsho	697	13	receptor	receptor	NN
cord-006229-7yoilsho	697	14	,	,	,
cord-006229-7yoilsho	697	15	a	a	DT
cord-006229-7yoilsho	697	16	member	member	NN
cord-006229-7yoilsho	697	17	of	of	IN
cord-006229-7yoilsho	697	18	the	the	DT
cord-006229-7yoilsho	697	19	class	class	NN
cord-006229-7yoilsho	697	20	B	b	NN
cord-006229-7yoilsho	697	21	of	of	IN
cord-006229-7yoilsho	697	22	GPCRs	gpcr	NNS
cord-006229-7yoilsho	697	23	which	which	WDT
cord-006229-7yoilsho	697	24	is	be	VBZ
cord-006229-7yoilsho	697	25	a	a	DT
cord-006229-7yoilsho	697	26	major	major	JJ
cord-006229-7yoilsho	697	27	regulator	regulator	NN
cord-006229-7yoilsho	697	28	of	of	IN
cord-006229-7yoilsho	697	29	calcium	calcium	NN
cord-006229-7yoilsho	697	30	homeostasis	homeostasis	NN
cord-006229-7yoilsho	697	31	in	in	IN
cord-006229-7yoilsho	697	32	the	the	DT
cord-006229-7yoilsho	697	33	body	body	NN
cord-006229-7yoilsho	697	34	and	and	CC
cord-006229-7yoilsho	697	35	a	a	DT
cord-006229-7yoilsho	697	36	key	key	JJ
cord-006229-7yoilsho	697	37	target	target	NN
cord-006229-7yoilsho	697	38	for	for	IN
cord-006229-7yoilsho	697	39	the	the	DT
cord-006229-7yoilsho	697	40	treatment	treatment	NN
cord-006229-7yoilsho	697	41	of	of	IN
cord-006229-7yoilsho	697	42	osteoporosis	osteoporosis	NN
cord-006229-7yoilsho	697	43	.	.	.
cord-006229-7yoilsho	698	1	From	from	IN
cord-006229-7yoilsho	698	2	two	two	CD
cord-006229-7yoilsho	698	3	rounds	round	NNS
cord-006229-7yoilsho	698	4	of	of	IN
cord-006229-7yoilsho	698	5	directed	direct	VBN
cord-006229-7yoilsho	698	6	evolution	evolution	NN
cord-006229-7yoilsho	698	7	in	in	IN
cord-006229-7yoilsho	698	8	yeast	yeast	NN
cord-006229-7yoilsho	698	9	we	-PRON-	PRP
cord-006229-7yoilsho	698	10	obtained	obtain	VBD
cord-006229-7yoilsho	698	11	several	several	JJ
cord-006229-7yoilsho	698	12	mutants	mutant	NNS
cord-006229-7yoilsho	698	13	of	of	IN
cord-006229-7yoilsho	698	14	parathyroid	parathyroid	JJ
cord-006229-7yoilsho	698	15	hormone	hormone	NN
cord-006229-7yoilsho	698	16	1	1	CD
cord-006229-7yoilsho	698	17	receptor	receptor	NN
cord-006229-7yoilsho	698	18	that	that	WDT
cord-006229-7yoilsho	698	19	exhibit	exhibit	VBP
cord-006229-7yoilsho	698	20	strongly	strongly	RB
cord-006229-7yoilsho	698	21	improved	improve	VBD
cord-006229-7yoilsho	698	22	expression	expression	NN
cord-006229-7yoilsho	698	23	levels	level	NNS
cord-006229-7yoilsho	698	24	and	and	CC
cord-006229-7yoilsho	698	25	that	that	WDT
cord-006229-7yoilsho	698	26	remain	remain	VBP
cord-006229-7yoilsho	698	27	stable	stable	JJ
cord-006229-7yoilsho	698	28	after	after	IN
cord-006229-7yoilsho	698	29	solubilization	solubilization	NN
cord-006229-7yoilsho	698	30	in	in	IN
cord-006229-7yoilsho	698	31	detergents	detergent	NNS
cord-006229-7yoilsho	698	32	.	.	.
cord-006229-7yoilsho	699	1	These	these	DT
cord-006229-7yoilsho	699	2	receptor	receptor	NN
cord-006229-7yoilsho	699	3	variants	variant	NNS
cord-006229-7yoilsho	699	4	are	be	VBP
cord-006229-7yoilsho	699	5	ideal	ideal	JJ
cord-006229-7yoilsho	699	6	candidates	candidate	NNS
cord-006229-7yoilsho	699	7	for	for	IN
cord-006229-7yoilsho	699	8	subsequent	subsequent	JJ
cord-006229-7yoilsho	699	9	structural	structural	JJ
cord-006229-7yoilsho	699	10	and	and	CC
cord-006229-7yoilsho	699	11	biophysical	biophysical	JJ
cord-006229-7yoilsho	699	12	analysis	analysis	NN
cord-006229-7yoilsho	699	13	.	.	.
cord-006229-7yoilsho	700	1	Opioid	opioid	JJ
cord-006229-7yoilsho	700	2	drugs	drug	NNS
cord-006229-7yoilsho	700	3	exert	exert	VBP
cord-006229-7yoilsho	700	4	nearly	nearly	RB
cord-006229-7yoilsho	700	5	all	all	DT
cord-006229-7yoilsho	700	6	of	of	IN
cord-006229-7yoilsho	700	7	their	-PRON-	PRP$
cord-006229-7yoilsho	700	8	clinically	clinically	RB
cord-006229-7yoilsho	700	9	relevant	relevant	JJ
cord-006229-7yoilsho	700	10	actions	action	NNS
cord-006229-7yoilsho	700	11	through	through	IN
cord-006229-7yoilsho	700	12	stimulation	stimulation	NN
cord-006229-7yoilsho	700	13	of	of	IN
cord-006229-7yoilsho	700	14	MORs	MORs	NNP
cord-006229-7yoilsho	700	15	(	(	-LRB-
cord-006229-7yoilsho	700	16	μ	μ	NN
cord-006229-7yoilsho	700	17	-	-	HYPH
cord-006229-7yoilsho	700	18	opioid	opioid	JJ
cord-006229-7yoilsho	700	19	receptors	receptor	NNS
cord-006229-7yoilsho	700	20	)	)	-RRB-
cord-006229-7yoilsho	700	21	.	.	.
cord-006229-7yoilsho	701	1	The	the	DT
cord-006229-7yoilsho	701	2	molecular	molecular	JJ
cord-006229-7yoilsho	701	3	biology	biology	NN
cord-006229-7yoilsho	701	4	of	of	IN
cord-006229-7yoilsho	701	5	endogenous	endogenous	JJ
cord-006229-7yoilsho	701	6	opioid	opioid	JJ
cord-006229-7yoilsho	701	7	peptides	peptide	NNS
cord-006229-7yoilsho	701	8	and	and	CC
cord-006229-7yoilsho	701	9	their	-PRON-	PRP$
cord-006229-7yoilsho	701	10	cognate	cognate	JJ
cord-006229-7yoilsho	701	11	receptors	receptor	NNS
cord-006229-7yoilsho	701	12	has	have	VBZ
cord-006229-7yoilsho	701	13	been	be	VBN
cord-006229-7yoilsho	701	14	studied	study	VBN
cord-006229-7yoilsho	701	15	extensively	extensively	RB
cord-006229-7yoilsho	701	16	in	in	IN
cord-006229-7yoilsho	701	17	vitro	vitro	FW
cord-006229-7yoilsho	701	18	.	.	.
cord-006229-7yoilsho	702	1	For	for	IN
cord-006229-7yoilsho	702	2	MOR	MOR	NNP
cord-006229-7yoilsho	702	3	,	,	,
cord-006229-7yoilsho	702	4	signaling	signal	VBG
cord-006229-7yoilsho	702	5	efficiency	efficiency	NN
cord-006229-7yoilsho	702	6	is	be	VBZ
cord-006229-7yoilsho	702	7	tightly	tightly	RB
cord-006229-7yoilsho	702	8	regulated	regulated	JJ
cord-006229-7yoilsho	702	9	and	and	CC
cord-006229-7yoilsho	702	10	ultimately	ultimately	RB
cord-006229-7yoilsho	702	11	limited	limit	VBN
cord-006229-7yoilsho	702	12	by	by	IN
cord-006229-7yoilsho	702	13	the	the	DT
cord-006229-7yoilsho	702	14	coordinated	coordinated	JJ
cord-006229-7yoilsho	702	15	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	702	16	of	of	IN
cord-006229-7yoilsho	702	17	intracellular	intracellular	JJ
cord-006229-7yoilsho	702	18	serine	serine	NN
cord-006229-7yoilsho	702	19	and	and	CC
cord-006229-7yoilsho	702	20	threonine	threonine	NN
cord-006229-7yoilsho	702	21	residues	residue	NNS
cord-006229-7yoilsho	702	22	.	.	.
cord-006229-7yoilsho	703	1	Morphine	morphine	NN
cord-006229-7yoilsho	703	2	induces	induce	VBZ
cord-006229-7yoilsho	703	3	a	a	DT
cord-006229-7yoilsho	703	4	selective	selective	JJ
cord-006229-7yoilsho	703	5	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	703	6	of	of	IN
cord-006229-7yoilsho	703	7	serine	serine	NN
cord-006229-7yoilsho	703	8	375	375	CD
cord-006229-7yoilsho	703	9	that	that	WDT
cord-006229-7yoilsho	703	10	is	be	VBZ
cord-006229-7yoilsho	703	11	predominantly	predominantly	RB
cord-006229-7yoilsho	703	12	catalyzed	catalyze	VBN
cord-006229-7yoilsho	703	13	by	by	IN
cord-006229-7yoilsho	703	14	G	g	NN
cord-006229-7yoilsho	703	15	protein	protein	NN
cord-006229-7yoilsho	703	16	-	-	HYPH
cord-006229-7yoilsho	703	17	coupled	couple	VBN
cord-006229-7yoilsho	703	18	receptor	receptor	NN
cord-006229-7yoilsho	703	19	kinase	kinase	NN
cord-006229-7yoilsho	703	20	5	5	CD
cord-006229-7yoilsho	703	21	.	.	.
cord-006229-7yoilsho	704	1	As	as	IN
cord-006229-7yoilsho	704	2	a	a	DT
cord-006229-7yoilsho	704	3	consequence	consequence	NN
cord-006229-7yoilsho	704	4	,	,	,
cord-006229-7yoilsho	704	5	the	the	DT
cord-006229-7yoilsho	704	6	selective	selective	JJ
cord-006229-7yoilsho	704	7	morphine	morphine	NN
cord-006229-7yoilsho	704	8	-	-	HYPH
cord-006229-7yoilsho	704	9	induced	induce	VBN
cord-006229-7yoilsho	704	10	S375	S375	NNS
cord-006229-7yoilsho	704	11	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	704	12	does	do	VBZ
cord-006229-7yoilsho	704	13	not	not	RB
cord-006229-7yoilsho	704	14	lead	lead	VB
cord-006229-7yoilsho	704	15	to	to	IN
cord-006229-7yoilsho	704	16	a	a	DT
cord-006229-7yoilsho	704	17	robust	robust	JJ
cord-006229-7yoilsho	704	18	beta	beta	NN
cord-006229-7yoilsho	704	19	-	-	HYPH
cord-006229-7yoilsho	704	20	arrestin	arrestin	JJ
cord-006229-7yoilsho	704	21	mobilization	mobilization	NN
cord-006229-7yoilsho	704	22	and	and	CC
cord-006229-7yoilsho	704	23	receptor	receptor	NN
cord-006229-7yoilsho	704	24	internalization	internalization	NN
cord-006229-7yoilsho	704	25	.	.	.
cord-006229-7yoilsho	705	1	By	by	IN
cord-006229-7yoilsho	705	2	contrast	contrast	NN
cord-006229-7yoilsho	705	3	,	,	,
cord-006229-7yoilsho	705	4	high	high	JJ
cord-006229-7yoilsho	705	5	-	-	HYPH
cord-006229-7yoilsho	705	6	efficacy	efficacy	NN
cord-006229-7yoilsho	705	7	opioid	opioid	NN
cord-006229-7yoilsho	705	8	agonists	agonist	NNS
cord-006229-7yoilsho	705	9	such	such	JJ
cord-006229-7yoilsho	705	10	as	as	IN
cord-006229-7yoilsho	705	11	fentanyl	fentanyl	NN
cord-006229-7yoilsho	705	12	or	or	CC
cord-006229-7yoilsho	705	13	etonitazene	etonitazene	NN
cord-006229-7yoilsho	705	14	not	not	RB
cord-006229-7yoilsho	705	15	only	only	RB
cord-006229-7yoilsho	705	16	induce	induce	VB
cord-006229-7yoilsho	705	17	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	705	18	of	of	IN
cord-006229-7yoilsho	705	19	S375	s375	NN
cord-006229-7yoilsho	705	20	but	but	CC
cord-006229-7yoilsho	705	21	also	also	RB
cord-006229-7yoilsho	705	22	drive	drive	VBP
cord-006229-7yoilsho	705	23	higher	high	JJR
cord-006229-7yoilsho	705	24	order	order	NN
cord-006229-7yoilsho	705	25	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	705	26	on	on	IN
cord-006229-7yoilsho	705	27	the	the	DT
cord-006229-7yoilsho	705	28	flanking	flank	VBG
cord-006229-7yoilsho	705	29	residues	residue	NNS
cord-006229-7yoilsho	705	30	threonine	threonine	NNP
cord-006229-7yoilsho	705	31	370	370	CD
cord-006229-7yoilsho	705	32	,	,	,
cord-006229-7yoilsho	705	33	threonine	threonine	NN
cord-006229-7yoilsho	705	34	376	376	CD
cord-006229-7yoilsho	705	35	,	,	,
cord-006229-7yoilsho	705	36	and	and	CC
cord-006229-7yoilsho	705	37	threonine	threonine	NN
cord-006229-7yoilsho	705	38	379	379	CD
cord-006229-7yoilsho	705	39	in	in	IN
cord-006229-7yoilsho	705	40	a	a	DT
cord-006229-7yoilsho	705	41	hierarchical	hierarchical	JJ
cord-006229-7yoilsho	705	42	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	705	43	cascade	cascade	NN
cord-006229-7yoilsho	705	44	that	that	WDT
cord-006229-7yoilsho	705	45	specifically	specifically	RB
cord-006229-7yoilsho	705	46	requires	require	VBZ
cord-006229-7yoilsho	705	47	GRK2	GRK2	NNP
cord-006229-7yoilsho	705	48	and	and	CC
cord-006229-7yoilsho	705	49	GRK3	GRK3	NNP
cord-006229-7yoilsho	705	50	isoforms	isoform	NNS
cord-006229-7yoilsho	705	51	.	.	.
cord-006229-7yoilsho	706	1	As	as	IN
cord-006229-7yoilsho	706	2	a	a	DT
cord-006229-7yoilsho	706	3	consequence	consequence	NN
cord-006229-7yoilsho	706	4	,	,	,
cord-006229-7yoilsho	706	5	multisite	multisite	JJ
cord-006229-7yoilsho	706	6	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	706	7	induced	induce	VBN
cord-006229-7yoilsho	706	8	by	by	IN
cord-006229-7yoilsho	706	9	potent	potent	JJ
cord-006229-7yoilsho	706	10	agonist	agonist	NN
cord-006229-7yoilsho	706	11	promotes	promote	VBZ
cord-006229-7yoilsho	706	12	both	both	DT
cord-006229-7yoilsho	706	13	betaarrestin	betaarrestin	NNP
cord-006229-7yoilsho	706	14	mobilization	mobilization	NN
cord-006229-7yoilsho	706	15	and	and	CC
cord-006229-7yoilsho	706	16	a	a	DT
cord-006229-7yoilsho	706	17	robust	robust	JJ
cord-006229-7yoilsho	706	18	receptor	receptor	NN
cord-006229-7yoilsho	706	19	internalization	internalization	NN
cord-006229-7yoilsho	706	20	.	.	.
cord-006229-7yoilsho	707	1	However	however	RB
cord-006229-7yoilsho	707	2	,	,	,
cord-006229-7yoilsho	707	3	little	little	JJ
cord-006229-7yoilsho	707	4	is	be	VBZ
cord-006229-7yoilsho	707	5	known	know	VBN
cord-006229-7yoilsho	707	6	about	about	IN
cord-006229-7yoilsho	707	7	agonist	agonist	NN
cord-006229-7yoilsho	707	8	-	-	HYPH
cord-006229-7yoilsho	707	9	selective	selective	JJ
cord-006229-7yoilsho	707	10	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	707	11	patterns	pattern	NNS
cord-006229-7yoilsho	707	12	in	in	IN
cord-006229-7yoilsho	707	13	vivo	vivo	NN
cord-006229-7yoilsho	707	14	after	after	IN
cord-006229-7yoilsho	707	15	acute	acute	JJ
cord-006229-7yoilsho	707	16	and	and	CC
cord-006229-7yoilsho	707	17	chronic	chronic	JJ
cord-006229-7yoilsho	707	18	drug	drug	NN
cord-006229-7yoilsho	707	19	administration	administration	NN
cord-006229-7yoilsho	707	20	.	.	.
cord-006229-7yoilsho	708	1	To	to	TO
cord-006229-7yoilsho	708	2	learn	learn	VB
cord-006229-7yoilsho	708	3	more	more	JJR
cord-006229-7yoilsho	708	4	about	about	IN
cord-006229-7yoilsho	708	5	MOR	MOR	NNP
cord-006229-7yoilsho	708	6	regulation	regulation	NN
cord-006229-7yoilsho	708	7	in	in	IN
cord-006229-7yoilsho	708	8	vivo	vivo	NN
cord-006229-7yoilsho	708	9	we	-PRON-	PRP
cord-006229-7yoilsho	708	10	have	have	VBP
cord-006229-7yoilsho	708	11	generated	generate	VBN
cord-006229-7yoilsho	708	12	a	a	DT
cord-006229-7yoilsho	708	13	new	new	JJ
cord-006229-7yoilsho	708	14	μopioid	μopioid	NN
cord-006229-7yoilsho	708	15	receptor	receptor	NN
cord-006229-7yoilsho	708	16	knock	knock	VB
cord-006229-7yoilsho	708	17	in	in	IN
cord-006229-7yoilsho	708	18	mouse	mouse	NN
cord-006229-7yoilsho	708	19	with	with	IN
cord-006229-7yoilsho	708	20	an	an	DT
cord-006229-7yoilsho	708	21	N	n	CD
cord-006229-7yoilsho	708	22	-	-	HYPH
cord-006229-7yoilsho	708	23	terminal	terminal	NN
cord-006229-7yoilsho	708	24	HA	HA	NNP
cord-006229-7yoilsho	708	25	-	-	HYPH
cord-006229-7yoilsho	708	26	tag	tag	NNP
cord-006229-7yoilsho	708	27	.	.	.
cord-006229-7yoilsho	709	1	Using	use	VBG
cord-006229-7yoilsho	709	2	these	these	DT
cord-006229-7yoilsho	709	3	mice	mouse	NNS
cord-006229-7yoilsho	709	4	,	,	,
cord-006229-7yoilsho	709	5	we	-PRON-	PRP
cord-006229-7yoilsho	709	6	were	be	VBD
cord-006229-7yoilsho	709	7	able	able	JJ
cord-006229-7yoilsho	709	8	to	to	TO
cord-006229-7yoilsho	709	9	study	study	VB
cord-006229-7yoilsho	709	10	in	in	IN
cord-006229-7yoilsho	709	11	vivo	vivo	NN
cord-006229-7yoilsho	709	12	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	709	13	of	of	IN
cord-006229-7yoilsho	709	14	an	an	DT
cord-006229-7yoilsho	709	15	endogenous	endogenous	JJ
cord-006229-7yoilsho	709	16	G	g	NN
cord-006229-7yoilsho	709	17	protein	protein	NN
cord-006229-7yoilsho	709	18	-	-	HYPH
cord-006229-7yoilsho	709	19	coupled	couple	VBN
cord-006229-7yoilsho	709	20	receptor	receptor	NN
cord-006229-7yoilsho	709	21	using	use	VBG
cord-006229-7yoilsho	709	22	both	both	CC
cord-006229-7yoilsho	709	23	mass	mass	NN
cord-006229-7yoilsho	709	24	spectrometry	spectrometry	NN
cord-006229-7yoilsho	709	25	and	and	CC
cord-006229-7yoilsho	709	26	phosphosite	phosphosite	JJ
cord-006229-7yoilsho	709	27	-	-	HYPH
cord-006229-7yoilsho	709	28	specific	specific	JJ
cord-006229-7yoilsho	709	29	antibodies	antibody	NNS
cord-006229-7yoilsho	709	30	.	.	.
cord-006229-7yoilsho	710	1	We	-PRON-	PRP
cord-006229-7yoilsho	710	2	were	be	VBD
cord-006229-7yoilsho	710	3	also	also	RB
cord-006229-7yoilsho	710	4	able	able	JJ
cord-006229-7yoilsho	710	5	to	to	TO
cord-006229-7yoilsho	710	6	address	address	VB
cord-006229-7yoilsho	710	7	the	the	DT
cord-006229-7yoilsho	710	8	question	question	NN
cord-006229-7yoilsho	710	9	which	which	WDT
cord-006229-7yoilsho	710	10	of	of	IN
cord-006229-7yoilsho	710	11	the	the	DT
cord-006229-7yoilsho	710	12	many	many	JJ
cord-006229-7yoilsho	710	13	putative	putative	JJ
cord-006229-7yoilsho	710	14	MOR	MOR	NNP
cord-006229-7yoilsho	710	15	splice	splice	NN
cord-006229-7yoilsho	710	16	variants	variant	NNS
cord-006229-7yoilsho	710	17	detected	detect	VBN
cord-006229-7yoilsho	710	18	on	on	IN
cord-006229-7yoilsho	710	19	the	the	DT
cord-006229-7yoilsho	710	20	mRNA	mRNA	NNP
cord-006229-7yoilsho	710	21	level	level	NN
cord-006229-7yoilsho	710	22	are	be	VBP
cord-006229-7yoilsho	710	23	indeed	indeed	RB
cord-006229-7yoilsho	710	24	expressed	express	VBN
cord-006229-7yoilsho	710	25	as	as	IN
cord-006229-7yoilsho	710	26	functional	functional	JJ
cord-006229-7yoilsho	710	27	receptors	receptor	NNS
cord-006229-7yoilsho	710	28	in	in	IN
cord-006229-7yoilsho	710	29	mouse	mouse	NN
cord-006229-7yoilsho	710	30	brain	brain	NN
cord-006229-7yoilsho	710	31	.	.	.
cord-006229-7yoilsho	711	1	Ion	ion	NN
cord-006229-7yoilsho	711	2	channels	channel	NNS
cord-006229-7yoilsho	711	3	061	061	CD
cord-006229-7yoilsho	711	4	HCN4	HCN4	NNP
cord-006229-7yoilsho	711	5	in	in	IN
cord-006229-7yoilsho	711	6	thalamic	thalamic	JJ
cord-006229-7yoilsho	711	7	relay	relay	NN
cord-006229-7yoilsho	711	8	neurons	neuron	NNS
cord-006229-7yoilsho	711	9	is	be	VBZ
cord-006229-7yoilsho	711	10	necessary	necessary	JJ
cord-006229-7yoilsho	711	11	for	for	IN
cord-006229-7yoilsho	711	12	oscillatory	oscillatory	JJ
cord-006229-7yoilsho	711	13	activity	activity	NN
cord-006229-7yoilsho	711	14	in	in	IN
cord-006229-7yoilsho	711	15	the	the	DT
cord-006229-7yoilsho	711	16	thalamocortical	thalamocortical	JJ
cord-006229-7yoilsho	711	17	system	system	NN
cord-006229-7yoilsho	711	18	Institut	Institut	NNP
cord-006229-7yoilsho	711	19	für	für	NNP
cord-006229-7yoilsho	712	1	Physiologie	Physiologie	NNP
cord-006229-7yoilsho	712	2	I	-PRON-	PRP
cord-006229-7yoilsho	712	3	,	,	,
cord-006229-7yoilsho	712	4	Westfälische	Westfälische	NNP
cord-006229-7yoilsho	712	5	Wilhelms	Wilhelms	NNP
cord-006229-7yoilsho	712	6	-	-	HYPH
cord-006229-7yoilsho	712	7	Universität	Universität	NNP
cord-006229-7yoilsho	712	8	,	,	,
cord-006229-7yoilsho	712	9	Münster	Münster	NNP
cord-006229-7yoilsho	713	1	,	,	,
cord-006229-7yoilsho	713	2	Germany	Germany	NNP
cord-006229-7yoilsho	713	3	HCN	HCN	NNP
cord-006229-7yoilsho	713	4	channels	channel	NNS
cord-006229-7yoilsho	713	5	underlie	underlie	VBP
cord-006229-7yoilsho	713	6	the	the	DT
cord-006229-7yoilsho	713	7	I	I	NNP
cord-006229-7yoilsho	713	8	h	h	NNP
cord-006229-7yoilsho	713	9	current	current	NN
cord-006229-7yoilsho	713	10	and	and	CC
cord-006229-7yoilsho	713	11	are	be	VBP
cord-006229-7yoilsho	713	12	involved	involve	VBN
cord-006229-7yoilsho	713	13	,	,	,
cord-006229-7yoilsho	713	14	among	among	IN
cord-006229-7yoilsho	713	15	other	other	JJ
cord-006229-7yoilsho	713	16	functions	function	NNS
cord-006229-7yoilsho	713	17	,	,	,
cord-006229-7yoilsho	713	18	in	in	IN
cord-006229-7yoilsho	713	19	the	the	DT
cord-006229-7yoilsho	713	20	genesis	genesis	NN
cord-006229-7yoilsho	713	21	of	of	IN
cord-006229-7yoilsho	713	22	epilepsy	epilepsy	NNP
cord-006229-7yoilsho	713	23	.	.	.
cord-006229-7yoilsho	714	1	The	the	DT
cord-006229-7yoilsho	714	2	significance	significance	NN
cord-006229-7yoilsho	714	3	of	of	IN
cord-006229-7yoilsho	714	4	HCN1	HCN1	NNP
cord-006229-7yoilsho	714	5	and	and	CC
cord-006229-7yoilsho	714	6	HCN2	HCN2	NNP
cord-006229-7yoilsho	714	7	isoforms	isoform	NNS
cord-006229-7yoilsho	714	8	for	for	IN
cord-006229-7yoilsho	714	9	brain	brain	NN
cord-006229-7yoilsho	714	10	function	function	NN
cord-006229-7yoilsho	714	11	and	and	CC
cord-006229-7yoilsho	714	12	epilepsy	epilepsy	NN
cord-006229-7yoilsho	714	13	has	have	VBZ
cord-006229-7yoilsho	714	14	been	be	VBN
cord-006229-7yoilsho	714	15	demonstrated	demonstrate	VBN
cord-006229-7yoilsho	714	16	,	,	,
cord-006229-7yoilsho	714	17	however	however	RB
cord-006229-7yoilsho	714	18	the	the	DT
cord-006229-7yoilsho	714	19	role	role	NN
cord-006229-7yoilsho	714	20	of	of	IN
cord-006229-7yoilsho	714	21	HCN4	HCN4	NNP
cord-006229-7yoilsho	714	22	,	,	,
cord-006229-7yoilsho	714	23	the	the	DT
cord-006229-7yoilsho	714	24	third	third	JJ
cord-006229-7yoilsho	714	25	major	major	JJ
cord-006229-7yoilsho	714	26	neuronal	neuronal	JJ
cord-006229-7yoilsho	714	27	HCN	HCN	NNP
cord-006229-7yoilsho	714	28	subunit	subunit	NN
cord-006229-7yoilsho	714	29	,	,	,
cord-006229-7yoilsho	714	30	is	be	VBZ
cord-006229-7yoilsho	714	31	not	not	RB
cord-006229-7yoilsho	714	32	known	know	VBN
cord-006229-7yoilsho	714	33	.	.	.
cord-006229-7yoilsho	715	1	Here	here	RB
cord-006229-7yoilsho	715	2	we	-PRON-	PRP
cord-006229-7yoilsho	715	3	show	show	VBP
cord-006229-7yoilsho	715	4	an	an	DT
cord-006229-7yoilsho	715	5	unexpected	unexpected	JJ
cord-006229-7yoilsho	715	6	role	role	NN
cord-006229-7yoilsho	715	7	of	of	IN
cord-006229-7yoilsho	715	8	HCN4	HCN4	NNP
cord-006229-7yoilsho	715	9	in	in	IN
cord-006229-7yoilsho	715	10	controlling	control	VBG
cord-006229-7yoilsho	715	11	oscillations	oscillation	NNS
cord-006229-7yoilsho	715	12	in	in	IN
cord-006229-7yoilsho	715	13	the	the	DT
cord-006229-7yoilsho	715	14	thalamocortical	thalamocortical	JJ
cord-006229-7yoilsho	715	15	network	network	NN
cord-006229-7yoilsho	715	16	.	.	.
cord-006229-7yoilsho	716	1	HCN4	HCN4	NNP
cord-006229-7yoilsho	716	2	is	be	VBZ
cord-006229-7yoilsho	716	3	predominantly	predominantly	RB
cord-006229-7yoilsho	716	4	expressed	express	VBN
cord-006229-7yoilsho	716	5	in	in	IN
cord-006229-7yoilsho	716	6	several	several	JJ
cord-006229-7yoilsho	716	7	thalamic	thalamic	JJ
cord-006229-7yoilsho	716	8	relay	relay	NN
cord-006229-7yoilsho	716	9	nuclei	nucleus	NNS
cord-006229-7yoilsho	716	10	,	,	,
cord-006229-7yoilsho	716	11	but	but	CC
cord-006229-7yoilsho	716	12	not	not	RB
cord-006229-7yoilsho	716	13	in	in	IN
cord-006229-7yoilsho	716	14	the	the	DT
cord-006229-7yoilsho	716	15	thalamic	thalamic	JJ
cord-006229-7yoilsho	716	16	reticular	reticular	JJ
cord-006229-7yoilsho	716	17	nucleus	nucleus	NN
cord-006229-7yoilsho	716	18	and	and	CC
cord-006229-7yoilsho	716	19	the	the	DT
cord-006229-7yoilsho	716	20	cerebral	cerebral	JJ
cord-006229-7yoilsho	716	21	cortex	cortex	NN
cord-006229-7yoilsho	716	22	.	.	.
cord-006229-7yoilsho	717	1	HCN4-deficient	hcn4-deficient	NN
cord-006229-7yoilsho	717	2	thalamocortical	thalamocortical	JJ
cord-006229-7yoilsho	717	3	relay	relay	NN
cord-006229-7yoilsho	717	4	neurons	neuron	NNS
cord-006229-7yoilsho	717	5	showed	show	VBD
cord-006229-7yoilsho	717	6	a	a	DT
cord-006229-7yoilsho	717	7	massive	massive	JJ
cord-006229-7yoilsho	717	8	reduction	reduction	NN
cord-006229-7yoilsho	717	9	of	of	IN
cord-006229-7yoilsho	717	10	I	I	NNP
cord-006229-7yoilsho	717	11	h	h	NN
cord-006229-7yoilsho	717	12	and	and	CC
cord-006229-7yoilsho	717	13	strongly	strongly	RB
cord-006229-7yoilsho	717	14	reduced	reduce	VBD
cord-006229-7yoilsho	717	15	intrinsic	intrinsic	JJ
cord-006229-7yoilsho	717	16	burst	burst	NN
cord-006229-7yoilsho	717	17	firing	fire	VBG
cord-006229-7yoilsho	717	18	.	.	.
cord-006229-7yoilsho	718	1	Evoked	evoke	VBN
cord-006229-7yoilsho	718	2	thalamic	thalamic	JJ
cord-006229-7yoilsho	718	3	oscillations	oscillation	NNS
cord-006229-7yoilsho	718	4	in	in	IN
cord-006229-7yoilsho	718	5	a	a	DT
cord-006229-7yoilsho	718	6	slice	slice	NN
cord-006229-7yoilsho	718	7	preparation	preparation	NN
cord-006229-7yoilsho	718	8	were	be	VBD
cord-006229-7yoilsho	718	9	completely	completely	RB
cord-006229-7yoilsho	718	10	abolished	abolish	VBN
cord-006229-7yoilsho	718	11	.	.	.
cord-006229-7yoilsho	719	1	In	in	IN
cord-006229-7yoilsho	719	2	vivo	vivo	NN
cord-006229-7yoilsho	719	3	,	,	,
cord-006229-7yoilsho	719	4	brain	brain	NN
cord-006229-7yoilsho	719	5	-	-	HYPH
cord-006229-7yoilsho	719	6	specific	specific	JJ
cord-006229-7yoilsho	719	7	HCN4	HCN4	NNP
cord-006229-7yoilsho	719	8	null	null	JJ
cord-006229-7yoilsho	719	9	mutants	mutant	NNS
cord-006229-7yoilsho	719	10	were	be	VBD
cord-006229-7yoilsho	719	11	protected	protect	VBN
cord-006229-7yoilsho	719	12	against	against	IN
cord-006229-7yoilsho	719	13	induced	induce	VBN
cord-006229-7yoilsho	719	14	spike	spike	NN
cord-006229-7yoilsho	719	15	-	-	HYPH
cord-006229-7yoilsho	719	16	and	and	CC
cord-006229-7yoilsho	719	17	-	-	HYPH
cord-006229-7yoilsho	719	18	wave	wave	NN
cord-006229-7yoilsho	719	19	discharges	discharge	NNS
cord-006229-7yoilsho	719	20	(	(	-LRB-
cord-006229-7yoilsho	719	21	SWD	SWD	NNP
cord-006229-7yoilsho	719	22	)	)	-RRB-
cord-006229-7yoilsho	719	23	,	,	,
cord-006229-7yoilsho	719	24	the	the	DT
cord-006229-7yoilsho	719	25	hallmark	hallmark	NN
cord-006229-7yoilsho	719	26	of	of	IN
cord-006229-7yoilsho	719	27	absence	absence	NN
cord-006229-7yoilsho	719	28	seizures	seizure	NNS
cord-006229-7yoilsho	719	29	.	.	.
cord-006229-7yoilsho	720	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	720	2	findings	finding	NNS
cord-006229-7yoilsho	720	3	indicate	indicate	VBP
cord-006229-7yoilsho	720	4	that	that	IN
cord-006229-7yoilsho	720	5	HCN4	HCN4	NNP
cord-006229-7yoilsho	720	6	is	be	VBZ
cord-006229-7yoilsho	720	7	necessary	necessary	JJ
cord-006229-7yoilsho	720	8	for	for	IN
cord-006229-7yoilsho	720	9	rhythmic	rhythmic	JJ
cord-006229-7yoilsho	720	10	intrathalamic	intrathalamic	JJ
cord-006229-7yoilsho	720	11	oscillations	oscillation	NNS
cord-006229-7yoilsho	720	12	and	and	CC
cord-006229-7yoilsho	720	13	that	that	IN
cord-006229-7yoilsho	720	14	the	the	DT
cord-006229-7yoilsho	720	15	channels	channel	NNS
cord-006229-7yoilsho	720	16	constitutes	constitute	VBZ
cord-006229-7yoilsho	720	17	an	an	DT
cord-006229-7yoilsho	720	18	important	important	JJ
cord-006229-7yoilsho	720	19	component	component	NN
cord-006229-7yoilsho	720	20	of	of	IN
cord-006229-7yoilsho	720	21	SWD	SWD	NNP
cord-006229-7yoilsho	720	22	generation	generation	NN
cord-006229-7yoilsho	720	23	.	.	.
cord-006229-7yoilsho	721	1	Ludwig	Ludwig	NNP
cord-006229-7yoilsho	721	2	-	-	HYPH
cord-006229-7yoilsho	721	3	Maximilians	Maximilians	NNP
cord-006229-7yoilsho	721	4	-	-	HYPH
cord-006229-7yoilsho	721	5	Universität	Universität	NNP
cord-006229-7yoilsho	721	6	,	,	,
cord-006229-7yoilsho	721	7	Walther	Walther	NNP
cord-006229-7yoilsho	721	8	-	-	HYPH
cord-006229-7yoilsho	721	9	Straub	Straub	NNP
cord-006229-7yoilsho	721	10	-	-	HYPH
cord-006229-7yoilsho	721	11	Institut	Institut	NNP
cord-006229-7yoilsho	721	12	für	für	IN
cord-006229-7yoilsho	721	13	Pharmakologie	Pharmakologie	NNP
cord-006229-7yoilsho	722	1	und	und	NNP
cord-006229-7yoilsho	722	2	Toxikologie	Toxikologie	NNP
cord-006229-7yoilsho	722	3	,	,	,
cord-006229-7yoilsho	722	4	München	München	NNP
cord-006229-7yoilsho	722	5	,	,	,
cord-006229-7yoilsho	722	6	Germany	Germany	NNP
cord-006229-7yoilsho	722	7	TRPC4	TRPC4	NNP
cord-006229-7yoilsho	722	8	and	and	CC
cord-006229-7yoilsho	722	9	5	5	CD
cord-006229-7yoilsho	722	10	channels	channel	NNS
cord-006229-7yoilsho	722	11	are	be	VBP
cord-006229-7yoilsho	722	12	members	member	NNS
cord-006229-7yoilsho	722	13	of	of	IN
cord-006229-7yoilsho	722	14	the	the	DT
cord-006229-7yoilsho	722	15	classical	classical	JJ
cord-006229-7yoilsho	722	16	transient	transient	JJ
cord-006229-7yoilsho	722	17	receptor	receptor	NN
cord-006229-7yoilsho	722	18	potential	potential	NN
cord-006229-7yoilsho	722	19	(	(	-LRB-
cord-006229-7yoilsho	722	20	TRPC	TRPC	NNP
cord-006229-7yoilsho	722	21	)	)	-RRB-
cord-006229-7yoilsho	722	22	family	family	NN
cord-006229-7yoilsho	722	23	whose	whose	WP$
cord-006229-7yoilsho	722	24	activation	activation	NN
cord-006229-7yoilsho	722	25	mechanism	mechanism	NN
cord-006229-7yoilsho	722	26	downstream	downstream	RB
cord-006229-7yoilsho	722	27	of	of	IN
cord-006229-7yoilsho	722	28	phospholipase	phospholipase	NN
cord-006229-7yoilsho	722	29	C	C	NNP
cord-006229-7yoilsho	722	30	(	(	-LRB-
cord-006229-7yoilsho	722	31	PLC	PLC	NNP
cord-006229-7yoilsho	722	32	)	)	-RRB-
cord-006229-7yoilsho	722	33	largely	largely	RB
cord-006229-7yoilsho	722	34	remained	remain	VBD
cord-006229-7yoilsho	722	35	elusive	elusive	JJ
cord-006229-7yoilsho	722	36	until	until	IN
cord-006229-7yoilsho	722	37	now	now	RB
cord-006229-7yoilsho	722	38	.	.	.
cord-006229-7yoilsho	723	1	While	while	IN
cord-006229-7yoilsho	723	2	TRPC3/6/7	TRPC3/6/7	NNP
cord-006229-7yoilsho	723	3	channels	channel	NNS
cord-006229-7yoilsho	723	4	are	be	VBP
cord-006229-7yoilsho	723	5	directly	directly	RB
cord-006229-7yoilsho	723	6	activated	activate	VBN
cord-006229-7yoilsho	723	7	by	by	IN
cord-006229-7yoilsho	723	8	diacylglycerol	diacylglycerol	NN
cord-006229-7yoilsho	723	9	(	(	-LRB-
cord-006229-7yoilsho	723	10	DAG	DAG	NNP
cord-006229-7yoilsho	723	11	)	)	-RRB-
cord-006229-7yoilsho	723	12	,	,	,
cord-006229-7yoilsho	723	13	TRPC4	TRPC4	NNP
cord-006229-7yoilsho	723	14	and	and	CC
cord-006229-7yoilsho	723	15	5	5	CD
cord-006229-7yoilsho	723	16	channels	channel	NNS
cord-006229-7yoilsho	723	17	are	be	VBP
cord-006229-7yoilsho	723	18	commonly	commonly	RB
cord-006229-7yoilsho	723	19	regarded	regard	VBN
cord-006229-7yoilsho	723	20	as	as	IN
cord-006229-7yoilsho	723	21	DAGinsensitive	DAGinsensitive	NNP
cord-006229-7yoilsho	723	22	.	.	.
cord-006229-7yoilsho	724	1	In	in	IN
cord-006229-7yoilsho	724	2	contrast	contrast	NN
cord-006229-7yoilsho	724	3	to	to	IN
cord-006229-7yoilsho	724	4	TRPC3/6/7	TRPC3/6/7	NNP
cord-006229-7yoilsho	724	5	channels	channel	NNS
cord-006229-7yoilsho	724	6	,	,	,
cord-006229-7yoilsho	724	7	they	-PRON-	PRP
cord-006229-7yoilsho	724	8	contain	contain	VBP
cord-006229-7yoilsho	724	9	a	a	DT
cord-006229-7yoilsho	724	10	C	c	NN
cord-006229-7yoilsho	724	11	-	-	HYPH
cord-006229-7yoilsho	724	12	terminal	terminal	NN
cord-006229-7yoilsho	724	13	PDZ	pdz	NN
cord-006229-7yoilsho	724	14	-	-	HYPH
cord-006229-7yoilsho	724	15	binding	bind	VBG
cord-006229-7yoilsho	724	16	motif	motif	NN
cord-006229-7yoilsho	724	17	allowing	allow	VBG
cord-006229-7yoilsho	724	18	for	for	IN
cord-006229-7yoilsho	724	19	binding	binding	NN
cord-006229-7yoilsho	724	20	of	of	IN
cord-006229-7yoilsho	724	21	Na	Na	NNP
cord-006229-7yoilsho	724	22	+	+	SYM
cord-006229-7yoilsho	724	23	/H	/H	.
cord-006229-7yoilsho	724	24	+	+	CC
cord-006229-7yoilsho	724	25	exchanger	exchanger	NN
cord-006229-7yoilsho	724	26	regulatory	regulatory	JJ
cord-006229-7yoilsho	724	27	factor	factor	NN
cord-006229-7yoilsho	724	28	(	(	-LRB-
cord-006229-7yoilsho	724	29	NHERF	NHERF	NNP
cord-006229-7yoilsho	724	30	)	)	-RRB-
cord-006229-7yoilsho	724	31	1	1	CD
cord-006229-7yoilsho	724	32	and	and	CC
cord-006229-7yoilsho	724	33	2	2	CD
cord-006229-7yoilsho	724	34	.	.	.
cord-006229-7yoilsho	725	1	Interestingly	interestingly	RB
cord-006229-7yoilsho	725	2	,	,	,
cord-006229-7yoilsho	725	3	performing	perform	VBG
cord-006229-7yoilsho	725	4	electrophysiological	electrophysiological	JJ
cord-006229-7yoilsho	725	5	measurements	measurement	NNS
cord-006229-7yoilsho	725	6	,	,	,
cord-006229-7yoilsho	725	7	co	co	NNS
cord-006229-7yoilsho	725	8	-	-	NNS
cord-006229-7yoilsho	725	9	immunoprecipitations	immunoprecipitation	NNS
cord-006229-7yoilsho	725	10	and	and	CC
cord-006229-7yoilsho	725	11	intermolecular	intermolecular	JJ
cord-006229-7yoilsho	725	12	dynamic	dynamic	JJ
cord-006229-7yoilsho	725	13	FRET	fret	NN
cord-006229-7yoilsho	725	14	experiments	experiment	NNS
cord-006229-7yoilsho	725	15	,	,	,
cord-006229-7yoilsho	725	16	we	-PRON-	PRP
cord-006229-7yoilsho	725	17	found	find	VBD
cord-006229-7yoilsho	725	18	that	that	IN
cord-006229-7yoilsho	725	19	dissociation	dissociation	NN
cord-006229-7yoilsho	725	20	of	of	IN
cord-006229-7yoilsho	725	21	NHERF	NHERF	NNP
cord-006229-7yoilsho	725	22	proteins	protein	NNS
cord-006229-7yoilsho	725	23	from	from	IN
cord-006229-7yoilsho	725	24	the	the	DT
cord-006229-7yoilsho	725	25	C	C	NNP
cord-006229-7yoilsho	725	26	-	-	HYPH
cord-006229-7yoilsho	725	27	terminus	terminus	NN
cord-006229-7yoilsho	725	28	of	of	IN
cord-006229-7yoilsho	725	29	TRPC5	trpc5	NN
cord-006229-7yoilsho	725	30	confers	confer	VBZ
cord-006229-7yoilsho	725	31	DAG	DAG	NNP
cord-006229-7yoilsho	725	32	-	-	HYPH
cord-006229-7yoilsho	725	33	sensitivity	sensitivity	NN
cord-006229-7yoilsho	725	34	on	on	IN
cord-006229-7yoilsho	725	35	TRPC5	trpc5	NN
cord-006229-7yoilsho	725	36	channels	channel	NNS
cord-006229-7yoilsho	725	37	.	.	.
cord-006229-7yoilsho	726	1	TRPC5	trpc5	NN
cord-006229-7yoilsho	726	2	channels	channel	NNS
cord-006229-7yoilsho	726	3	were	be	VBD
cord-006229-7yoilsho	726	4	DAG	DAG	NNP
cord-006229-7yoilsho	726	5	-	-	HYPH
cord-006229-7yoilsho	726	6	sensitive	sensitive	JJ
cord-006229-7yoilsho	726	7	under	under	IN
cord-006229-7yoilsho	726	8	the	the	DT
cord-006229-7yoilsho	726	9	following	follow	VBG
cord-006229-7yoilsho	726	10	experimental	experimental	JJ
cord-006229-7yoilsho	726	11	conditions	condition	NNS
cord-006229-7yoilsho	726	12	:	:	:
cord-006229-7yoilsho	726	13	inhibition	inhibition	NN
cord-006229-7yoilsho	726	14	of	of	IN
cord-006229-7yoilsho	726	15	protein	protein	NN
cord-006229-7yoilsho	726	16	kinase	kinase	NN
cord-006229-7yoilsho	726	17	C	c	NN
cord-006229-7yoilsho	726	18	,	,	,
cord-006229-7yoilsho	726	19	amino	amino	NN
cord-006229-7yoilsho	726	20	acid	acid	NN
cord-006229-7yoilsho	726	21	exchange	exchange	NN
cord-006229-7yoilsho	726	22	in	in	IN
cord-006229-7yoilsho	726	23	the	the	DT
cord-006229-7yoilsho	726	24	C	C	NNP
cord-006229-7yoilsho	726	25	-	-	HYPH
cord-006229-7yoilsho	726	26	terminal	terminal	NN
cord-006229-7yoilsho	726	27	PDZ	pdz	NN
cord-006229-7yoilsho	726	28	-	-	HYPH
cord-006229-7yoilsho	726	29	binding	bind	VBG
cord-006229-7yoilsho	726	30	motif	motif	NN
cord-006229-7yoilsho	726	31	,	,	,
cord-006229-7yoilsho	726	32	PIP	PIP	NNP
cord-006229-7yoilsho	726	33	2	2	CD
cord-006229-7yoilsho	726	34	depletion	depletion	NN
cord-006229-7yoilsho	726	35	with	with	IN
cord-006229-7yoilsho	726	36	and	and	CC
cord-006229-7yoilsho	726	37	without	without	IN
cord-006229-7yoilsho	726	38	involvement	involvement	NN
cord-006229-7yoilsho	726	39	of	of	IN
cord-006229-7yoilsho	726	40	PLC	PLC	NNP
cord-006229-7yoilsho	726	41	,	,	,
cord-006229-7yoilsho	726	42	over	over	IN
cord-006229-7yoilsho	726	43	-	-	HYPH
cord-006229-7yoilsho	726	44	expression	expression	NN
cord-006229-7yoilsho	726	45	of	of	IN
cord-006229-7yoilsho	726	46	G	g	NN
cord-006229-7yoilsho	726	47	-	-	HYPH
cord-006229-7yoilsho	726	48	protein	protein	NN
cord-006229-7yoilsho	726	49	coupled	coupled	JJ
cord-006229-7yoilsho	726	50	receptors	receptor	NNS
cord-006229-7yoilsho	726	51	,	,	,
cord-006229-7yoilsho	726	52	down	down	IN
cord-006229-7yoilsho	726	53	-	-	HYPH
cord-006229-7yoilsho	726	54	regulation	regulation	NN
cord-006229-7yoilsho	726	55	of	of	IN
cord-006229-7yoilsho	726	56	endogenous	endogenous	JJ
cord-006229-7yoilsho	726	57	NHERF1	NHERF1	NNP
cord-006229-7yoilsho	726	58	and	and	CC
cord-006229-7yoilsho	726	59	2	2	CD
cord-006229-7yoilsho	726	60	proteins	protein	NNS
cord-006229-7yoilsho	726	61	and	and	CC
cord-006229-7yoilsho	726	62	overexpression	overexpression	NN
cord-006229-7yoilsho	726	63	of	of	IN
cord-006229-7yoilsho	726	64	a	a	DT
cord-006229-7yoilsho	726	65	NHERF1	NHERF1	NNP
cord-006229-7yoilsho	726	66	mutant	mutant	NN
cord-006229-7yoilsho	726	67	incapable	incapable	JJ
cord-006229-7yoilsho	726	68	of	of	IN
cord-006229-7yoilsho	726	69	TRPC5	trpc5	DT
cord-006229-7yoilsho	726	70	binding	binding	NN
cord-006229-7yoilsho	726	71	.	.	.
cord-006229-7yoilsho	727	1	These	these	DT
cord-006229-7yoilsho	727	2	findings	finding	NNS
cord-006229-7yoilsho	727	3	strongly	strongly	RB
cord-006229-7yoilsho	727	4	argue	argue	VBP
cord-006229-7yoilsho	727	5	for	for	IN
cord-006229-7yoilsho	727	6	NHERF	NHERF	NNP
cord-006229-7yoilsho	727	7	proteins	protein	NNS
cord-006229-7yoilsho	727	8	as	as	IN
cord-006229-7yoilsho	727	9	molecular	molecular	JJ
cord-006229-7yoilsho	727	10	determinants	determinant	NNS
cord-006229-7yoilsho	727	11	for	for	IN
cord-006229-7yoilsho	727	12	channel	channel	NN
cord-006229-7yoilsho	727	13	activation	activation	NN
cord-006229-7yoilsho	727	14	.	.	.
cord-006229-7yoilsho	728	1	Interestingly	interestingly	RB
cord-006229-7yoilsho	728	2	,	,	,
cord-006229-7yoilsho	728	3	PIP	PIP	NNP
cord-006229-7yoilsho	728	4	2	2	CD
cord-006229-7yoilsho	728	5	depletion	depletion	NN
cord-006229-7yoilsho	728	6	itself	-PRON-	PRP
cord-006229-7yoilsho	728	7	caused	cause	VBD
cord-006229-7yoilsho	728	8	slight	slight	JJ
cord-006229-7yoilsho	728	9	TRPC5	trpc5	IN
cord-006229-7yoilsho	728	10	current	current	JJ
cord-006229-7yoilsho	728	11	increases	increase	NNS
cord-006229-7yoilsho	728	12	while	while	IN
cord-006229-7yoilsho	728	13	during	during	IN
cord-006229-7yoilsho	728	14	PIP	PIP	NNP
cord-006229-7yoilsho	728	15	2	2	CD
cord-006229-7yoilsho	728	16	depletion	depletion	NN
cord-006229-7yoilsho	728	17	,	,	,
cord-006229-7yoilsho	728	18	the	the	DT
cord-006229-7yoilsho	728	19	membrane	membrane	NN
cord-006229-7yoilsho	728	20	permeable	permeable	JJ
cord-006229-7yoilsho	728	21	DAG	DAG	NNP
cord-006229-7yoilsho	728	22	analogue	analogue	NN
cord-006229-7yoilsho	728	23	OAG	OAG	NNP
cord-006229-7yoilsho	728	24	evoked	evoke	VBD
cord-006229-7yoilsho	728	25	even	even	RB
cord-006229-7yoilsho	728	26	higher	high	JJR
cord-006229-7yoilsho	728	27	TRPC5	trpc5	NN
cord-006229-7yoilsho	728	28	currents	current	NNS
cord-006229-7yoilsho	728	29	suggesting	suggest	VBG
cord-006229-7yoilsho	728	30	that	that	IN
cord-006229-7yoilsho	728	31	PIP	PIP	NNP
cord-006229-7yoilsho	728	32	2	2	CD
cord-006229-7yoilsho	728	33	depletion	depletion	NN
cord-006229-7yoilsho	728	34	induces	induce	VBZ
cord-006229-7yoilsho	728	35	an	an	DT
cord-006229-7yoilsho	728	36	active	active	JJ
cord-006229-7yoilsho	728	37	and	and	CC
cord-006229-7yoilsho	728	38	DAG	DAG	NNP
cord-006229-7yoilsho	728	39	-	-	HYPH
cord-006229-7yoilsho	728	40	sensitive	sensitive	JJ
cord-006229-7yoilsho	728	41	channel	channel	NN
cord-006229-7yoilsho	728	42	conformation	conformation	NN
cord-006229-7yoilsho	728	43	.	.	.
cord-006229-7yoilsho	729	1	Receptor	receptor	NN
cord-006229-7yoilsho	729	2	mediated	mediate	VBN
cord-006229-7yoilsho	730	1	PIP	PIP	NNP
cord-006229-7yoilsho	730	2	2	2	CD
cord-006229-7yoilsho	730	3	depletion	depletion	NN
cord-006229-7yoilsho	730	4	also	also	RB
cord-006229-7yoilsho	730	5	resulted	result	VBD
cord-006229-7yoilsho	730	6	in	in	IN
cord-006229-7yoilsho	730	7	dissociation	dissociation	NN
cord-006229-7yoilsho	730	8	of	of	IN
cord-006229-7yoilsho	730	9	NHERF1	NHERF1	NNP
cord-006229-7yoilsho	730	10	and	and	CC
cord-006229-7yoilsho	730	11	2	2	CD
cord-006229-7yoilsho	730	12	from	from	IN
cord-006229-7yoilsho	730	13	the	the	DT
cord-006229-7yoilsho	730	14	C	c	NN
cord-006229-7yoilsho	730	15	-	-	HYPH
cord-006229-7yoilsho	730	16	terminus	terminus	NN
cord-006229-7yoilsho	730	17	of	of	IN
cord-006229-7yoilsho	730	18	TRPC5	TRPC5	NNP
cord-006229-7yoilsho	730	19	thereby	thereby	RB
cord-006229-7yoilsho	730	20	eliciting	elicit	VBG
cord-006229-7yoilsho	730	21	a	a	DT
cord-006229-7yoilsho	730	22	DAG	DAG	NNP
cord-006229-7yoilsho	730	23	-	-	HYPH
cord-006229-7yoilsho	730	24	sensitive	sensitive	JJ
cord-006229-7yoilsho	730	25	TRPC5	trpc5	NN
cord-006229-7yoilsho	730	26	channel	channel	NN
cord-006229-7yoilsho	730	27	conformation	conformation	NN
cord-006229-7yoilsho	730	28	.	.	.
cord-006229-7yoilsho	731	1	Thus	thus	RB
cord-006229-7yoilsho	731	2	,	,	,
cord-006229-7yoilsho	731	3	our	-PRON-	PRP$
cord-006229-7yoilsho	731	4	findings	finding	NNS
cord-006229-7yoilsho	731	5	suggest	suggest	VBP
cord-006229-7yoilsho	731	6	that	that	IN
cord-006229-7yoilsho	731	7	DAG	DAG	NNP
cord-006229-7yoilsho	731	8	-	-	HYPH
cord-006229-7yoilsho	731	9	sensitivity	sensitivity	NN
cord-006229-7yoilsho	731	10	of	of	IN
cord-006229-7yoilsho	731	11	TRPC5	trpc5	NN
cord-006229-7yoilsho	731	12	is	be	VBZ
cord-006229-7yoilsho	731	13	the	the	DT
cord-006229-7yoilsho	731	14	result	result	NN
cord-006229-7yoilsho	731	15	of	of	IN
cord-006229-7yoilsho	731	16	an	an	DT
cord-006229-7yoilsho	731	17	activation	activation	NN
cord-006229-7yoilsho	731	18	cascade	cascade	NN
cord-006229-7yoilsho	731	19	starting	start	VBG
cord-006229-7yoilsho	731	20	with	with	IN
cord-006229-7yoilsho	731	21	PIP	PIP	NNP
cord-006229-7yoilsho	731	22	2	2	CD
cord-006229-7yoilsho	731	23	depletion	depletion	NN
cord-006229-7yoilsho	731	24	and	and	CC
cord-006229-7yoilsho	731	25	subsequent	subsequent	JJ
cord-006229-7yoilsho	731	26	dynamic	dynamic	JJ
cord-006229-7yoilsho	731	27	dissociation	dissociation	NN
cord-006229-7yoilsho	731	28	of	of	IN
cord-006229-7yoilsho	731	29	NHERF1	NHERF1	NNP
cord-006229-7yoilsho	731	30	and	and	CC
cord-006229-7yoilsho	731	31	2	2	CD
cord-006229-7yoilsho	731	32	from	from	IN
cord-006229-7yoilsho	731	33	the	the	DT
cord-006229-7yoilsho	731	34	C	c	NN
cord-006229-7yoilsho	731	35	-	-	HYPH
cord-006229-7yoilsho	731	36	terminus	terminus	NN
cord-006229-7yoilsho	731	37	of	of	IN
cord-006229-7yoilsho	731	38	TRPC5	trpc5	XX
cord-006229-7yoilsho	731	39	.	.	.
cord-006229-7yoilsho	732	1	Altogether	altogether	RB
cord-006229-7yoilsho	732	2	,	,	,
cord-006229-7yoilsho	732	3	DAGsensitivity	dagsensitivity	NN
cord-006229-7yoilsho	732	4	is	be	VBZ
cord-006229-7yoilsho	732	5	a	a	DT
cord-006229-7yoilsho	732	6	unifying	unifying	JJ
cord-006229-7yoilsho	732	7	functional	functional	JJ
cord-006229-7yoilsho	732	8	hallmark	hallmark	NN
cord-006229-7yoilsho	732	9	of	of	IN
cord-006229-7yoilsho	732	10	all	all	DT
cord-006229-7yoilsho	732	11	TRPC	TRPC	NNP
cord-006229-7yoilsho	732	12	channels	channel	NNS
cord-006229-7yoilsho	732	13	.	.	.
cord-006229-7yoilsho	733	1	The	the	DT
cord-006229-7yoilsho	733	2	melastatin	melastatin	NN
cord-006229-7yoilsho	733	3	-	-	HYPH
cord-006229-7yoilsho	733	4	related	relate	VBN
cord-006229-7yoilsho	733	5	transient	transient	JJ
cord-006229-7yoilsho	733	6	receptor	receptor	NN
cord-006229-7yoilsho	733	7	potential	potential	JJ
cord-006229-7yoilsho	733	8	channel	channel	NN
cord-006229-7yoilsho	733	9	TRPM3	TRPM3	NNS
cord-006229-7yoilsho	733	10	is	be	VBZ
cord-006229-7yoilsho	733	11	a	a	DT
cord-006229-7yoilsho	733	12	heat	heat	NN
cord-006229-7yoilsho	733	13	-	-	HYPH
cord-006229-7yoilsho	733	14	activated	activate	VBN
cord-006229-7yoilsho	733	15	nonselective	nonselective	JJ
cord-006229-7yoilsho	733	16	cation	cation	NN
cord-006229-7yoilsho	733	17	channel	channel	NN
cord-006229-7yoilsho	733	18	expressed	express	VBN
cord-006229-7yoilsho	733	19	in	in	IN
cord-006229-7yoilsho	733	20	sensory	sensory	JJ
cord-006229-7yoilsho	733	21	neurons	neuron	NNS
cord-006229-7yoilsho	733	22	of	of	IN
cord-006229-7yoilsho	733	23	dorsal	dorsal	JJ
cord-006229-7yoilsho	733	24	root	root	NN
cord-006229-7yoilsho	733	25	ganglia	ganglion	NNS
cord-006229-7yoilsho	733	26	.	.	.
cord-006229-7yoilsho	734	1	Since	since	IN
cord-006229-7yoilsho	734	2	TRPM3-deficient	trpm3-deficient	CD
cord-006229-7yoilsho	734	3	mice	mouse	NNS
cord-006229-7yoilsho	734	4	show	show	VBP
cord-006229-7yoilsho	734	5	impaired	impair	VBD
cord-006229-7yoilsho	734	6	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	734	7	thermal	thermal	JJ
cord-006229-7yoilsho	734	8	hyperalgesia	hyperalgesia	NN
cord-006229-7yoilsho	734	9	,	,	,
cord-006229-7yoilsho	734	10	the	the	DT
cord-006229-7yoilsho	734	11	pharmacological	pharmacological	JJ
cord-006229-7yoilsho	734	12	inhibition	inhibition	NN
cord-006229-7yoilsho	734	13	of	of	IN
cord-006229-7yoilsho	734	14	TRPM3	TRPM3	NNS
cord-006229-7yoilsho	734	15	may	may	MD
cord-006229-7yoilsho	734	16	exert	exert	VB
cord-006229-7yoilsho	734	17	antinociceptive	antinociceptive	JJ
cord-006229-7yoilsho	734	18	properties	property	NNS
cord-006229-7yoilsho	734	19	.	.	.
cord-006229-7yoilsho	735	1	Fluorometric	Fluorometric	NNP
cord-006229-7yoilsho	736	1	Ca	ca	NN
cord-006229-7yoilsho	736	2	2	2	CD
cord-006229-7yoilsho	736	3	+	+	SYM
cord-006229-7yoilsho	736	4	assays	assay	NNS
cord-006229-7yoilsho	736	5	and	and	CC
cord-006229-7yoilsho	736	6	a	a	DT
cord-006229-7yoilsho	736	7	compound	compound	NN
cord-006229-7yoilsho	736	8	library	library	NN
cord-006229-7yoilsho	736	9	containing	contain	VBG
cord-006229-7yoilsho	736	10	approved	approve	VBN
cord-006229-7yoilsho	736	11	drugs	drug	NNS
cord-006229-7yoilsho	736	12	were	be	VBD
cord-006229-7yoilsho	736	13	used	use	VBN
cord-006229-7yoilsho	736	14	to	to	TO
cord-006229-7yoilsho	736	15	identify	identify	VB
cord-006229-7yoilsho	736	16	TRPM3	TRPM3	NNS
cord-006229-7yoilsho	736	17	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	736	18	and	and	CC
cord-006229-7yoilsho	736	19	to	to	TO
cord-006229-7yoilsho	736	20	characterize	characterize	VB
cord-006229-7yoilsho	736	21	their	-PRON-	PRP$
cord-006229-7yoilsho	736	22	potency	potency	NN
cord-006229-7yoilsho	736	23	and	and	CC
cord-006229-7yoilsho	736	24	selectivity	selectivity	NN
cord-006229-7yoilsho	736	25	.	.	.
cord-006229-7yoilsho	737	1	Biophysical	biophysical	JJ
cord-006229-7yoilsho	737	2	properties	property	NNS
cord-006229-7yoilsho	737	3	of	of	IN
cord-006229-7yoilsho	737	4	the	the	DT
cord-006229-7yoilsho	737	5	block	block	NN
cord-006229-7yoilsho	737	6	were	be	VBD
cord-006229-7yoilsho	737	7	assessed	assess	VBN
cord-006229-7yoilsho	737	8	using	use	VBG
cord-006229-7yoilsho	737	9	electrophysiological	electrophysiological	JJ
cord-006229-7yoilsho	737	10	patch	patch	NN
cord-006229-7yoilsho	737	11	-	-	HYPH
cord-006229-7yoilsho	737	12	clamp	clamp	NN
cord-006229-7yoilsho	737	13	methods	method	NNS
cord-006229-7yoilsho	737	14	.	.	.
cord-006229-7yoilsho	738	1	Microfluorometry	Microfluorometry	NNP
cord-006229-7yoilsho	738	2	in	in	IN
cord-006229-7yoilsho	738	3	Fura-2-loaded	Fura-2-loaded	NNP
cord-006229-7yoilsho	738	4	single	single	JJ
cord-006229-7yoilsho	738	5	cells	cell	NNS
cord-006229-7yoilsho	738	6	was	be	VBD
cord-006229-7yoilsho	738	7	applied	apply	VBN
cord-006229-7yoilsho	738	8	to	to	TO
cord-006229-7yoilsho	738	9	monitor	monitor	VB
cord-006229-7yoilsho	738	10	[	[	-LRB-
cord-006229-7yoilsho	739	1	Ca	ca	NN
cord-006229-7yoilsho	739	2	2	2	CD
cord-006229-7yoilsho	739	3	+	+	SYM
cord-006229-7yoilsho	739	4	]	]	-RRB-
cord-006229-7yoilsho	739	5	i	i	PRP
cord-006229-7yoilsho	739	6	signals	signal	VBZ
cord-006229-7yoilsho	739	7	in	in	IN
cord-006229-7yoilsho	739	8	isolated	isolate	VBN
cord-006229-7yoilsho	739	9	dorsal	dorsal	JJ
cord-006229-7yoilsho	739	10	root	root	NN
cord-006229-7yoilsho	739	11	ganglion	ganglion	NN
cord-006229-7yoilsho	739	12	(	(	-LRB-
cord-006229-7yoilsho	739	13	DRG	DRG	NNP
cord-006229-7yoilsho	739	14	)	)	-RRB-
cord-006229-7yoilsho	739	15	neurons	neuron	NNS
cord-006229-7yoilsho	739	16	.	.	.
cord-006229-7yoilsho	740	1	Analgesic	analgesic	JJ
cord-006229-7yoilsho	740	2	effects	effect	NNS
cord-006229-7yoilsho	740	3	were	be	VBD
cord-006229-7yoilsho	740	4	assessed	assess	VBN
cord-006229-7yoilsho	740	5	applying	apply	VBG
cord-006229-7yoilsho	740	6	pregnenolone	pregnenolone	NN
cord-006229-7yoilsho	740	7	sulfate	sulfate	NN
cord-006229-7yoilsho	740	8	(	(	-LRB-
cord-006229-7yoilsho	740	9	PregS)-induced	pregs)-induce	VBN
cord-006229-7yoilsho	740	10	chemical	chemical	NN
cord-006229-7yoilsho	740	11	pain	pain	NN
cord-006229-7yoilsho	740	12	and	and	CC
cord-006229-7yoilsho	740	13	heat	heat	NN
cord-006229-7yoilsho	740	14	stimuli	stimulus	NNS
cord-006229-7yoilsho	740	15	at	at	IN
cord-006229-7yoilsho	740	16	mice	mouse	NNS
cord-006229-7yoilsho	740	17	.	.	.
cord-006229-7yoilsho	741	1	In	in	IN
cord-006229-7yoilsho	741	2	the	the	DT
cord-006229-7yoilsho	741	3	screening	screening	NN
cord-006229-7yoilsho	741	4	approach	approach	NN
cord-006229-7yoilsho	741	5	using	use	VBG
cord-006229-7yoilsho	741	6	stably	stably	RB
cord-006229-7yoilsho	741	7	transfected	transfecte	VBN
cord-006229-7yoilsho	741	8	HEK	HEK	NNP
cord-006229-7yoilsho	741	9	TRPM3	TRPM3	NNS
cord-006229-7yoilsho	741	10	cells	cell	NNS
cord-006229-7yoilsho	741	11	we	-PRON-	PRP
cord-006229-7yoilsho	741	12	identified	identify	VBD
cord-006229-7yoilsho	741	13	the	the	DT
cord-006229-7yoilsho	741	14	nonsteroidal	nonsteroidal	JJ
cord-006229-7yoilsho	741	15	anti	anti	JJ
cord-006229-7yoilsho	741	16	-	-	JJ
cord-006229-7yoilsho	741	17	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	741	18	drug	drug	NN
cord-006229-7yoilsho	741	19	(	(	-LRB-
cord-006229-7yoilsho	741	20	NSAID	NSAID	NNP
cord-006229-7yoilsho	741	21	)	)	-RRB-
cord-006229-7yoilsho	741	22	diclofenac	diclofenac	NNP
cord-006229-7yoilsho	741	23	,	,	,
cord-006229-7yoilsho	741	24	the	the	DT
cord-006229-7yoilsho	741	25	tetracyclic	tetracyclic	NNP
cord-006229-7yoilsho	741	26	antidepressant	antidepressant	JJ
cord-006229-7yoilsho	741	27	maprotiline	maprotiline	NN
cord-006229-7yoilsho	741	28	and	and	CC
cord-006229-7yoilsho	741	29	the	the	DT
cord-006229-7yoilsho	741	30	anticonvulsant	anticonvulsant	JJ
cord-006229-7yoilsho	741	31	primidone	primidone	NN
cord-006229-7yoilsho	741	32	as	as	IN
cord-006229-7yoilsho	741	33	highly	highly	RB
cord-006229-7yoilsho	741	34	efficient	efficient	JJ
cord-006229-7yoilsho	741	35	TRPM3	TRPM3	NNS
cord-006229-7yoilsho	741	36	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	741	37	.	.	.
cord-006229-7yoilsho	742	1	The	the	DT
cord-006229-7yoilsho	742	2	compounds	compound	NNS
cord-006229-7yoilsho	742	3	exhibited	exhibit	VBD
cord-006229-7yoilsho	742	4	half	half	RB
cord-006229-7yoilsho	742	5	-	-	HYPH
cord-006229-7yoilsho	742	6	maximal	maximal	JJ
cord-006229-7yoilsho	742	7	inhibitory	inhibitory	JJ
cord-006229-7yoilsho	742	8	concentrations	concentration	NNS
cord-006229-7yoilsho	742	9	of	of	IN
cord-006229-7yoilsho	743	1	0.6	0.6	CD
cord-006229-7yoilsho	743	2	-	-	SYM
cord-006229-7yoilsho	743	3	6	6	CD
cord-006229-7yoilsho	743	4	µM.	µm.	NN
cord-006229-7yoilsho	743	5	The	the	DT
cord-006229-7yoilsho	743	6	selectivity	selectivity	NN
cord-006229-7yoilsho	743	7	profiles	profile	NNS
cord-006229-7yoilsho	743	8	of	of	IN
cord-006229-7yoilsho	743	9	maprotiline	maprotiline	NN
cord-006229-7yoilsho	743	10	and	and	CC
cord-006229-7yoilsho	743	11	primidone	primidone	NN
cord-006229-7yoilsho	743	12	for	for	IN
cord-006229-7yoilsho	743	13	TRPM3	TRPM3	NNS
cord-006229-7yoilsho	743	14	were	be	VBD
cord-006229-7yoilsho	743	15	promising	promise	VBG
cord-006229-7yoilsho	743	16	with	with	IN
cord-006229-7yoilsho	743	17	no	no	DT
cord-006229-7yoilsho	743	18	inhibitory	inhibitory	JJ
cord-006229-7yoilsho	743	19	effects	effect	NNS
cord-006229-7yoilsho	743	20	on	on	IN
cord-006229-7yoilsho	743	21	TRPM2	TRPM2	VBN
cord-006229-7yoilsho	743	22	,	,	,
cord-006229-7yoilsho	743	23	TRPM8	TRPM8	NNP
cord-006229-7yoilsho	743	24	,	,	,
cord-006229-7yoilsho	743	25	TRPA1	trpa1	XX
cord-006229-7yoilsho	743	26	,	,	,
cord-006229-7yoilsho	743	27	TRPV1	TRPV1	NNP
cord-006229-7yoilsho	743	28	,	,	,
cord-006229-7yoilsho	743	29	TRPC5	trpc5	ADD
cord-006229-7yoilsho	743	30	,	,	,
cord-006229-7yoilsho	743	31	TRPC6	TRPC6	NNP
cord-006229-7yoilsho	743	32	and	and	CC
cord-006229-7yoilsho	743	33	P2X7	P2X7	NNP
cord-006229-7yoilsho	743	34	receptor	receptor	NN
cord-006229-7yoilsho	743	35	channels	channel	NNS
cord-006229-7yoilsho	743	36	.	.	.
cord-006229-7yoilsho	744	1	Primidone	Primidone	NNP
cord-006229-7yoilsho	744	2	inhibited	inhibit	VBD
cord-006229-7yoilsho	744	3	PregS	PregS	NNP
cord-006229-7yoilsho	744	4	-	-	HYPH
cord-006229-7yoilsho	744	5	induced	induce	VBN
cord-006229-7yoilsho	744	6	[	[	-LRB-
cord-006229-7yoilsho	745	1	Ca	ca	RB
cord-006229-7yoilsho	745	2	2	2	CD
cord-006229-7yoilsho	746	1	+	+	LS
cord-006229-7yoilsho	746	2	]	]	-RRB-
cord-006229-7yoilsho	746	3	i	i	PRP
cord-006229-7yoilsho	746	4	signals	signal	VBZ
cord-006229-7yoilsho	746	5	in	in	IN
cord-006229-7yoilsho	746	6	rat	rat	NN
cord-006229-7yoilsho	746	7	DRG	DRG	NNP
cord-006229-7yoilsho	746	8	neurones	neurone	NNS
cord-006229-7yoilsho	746	9	,	,	,
cord-006229-7yoilsho	746	10	indicating	indicate	VBG
cord-006229-7yoilsho	746	11	a	a	DT
cord-006229-7yoilsho	746	12	block	block	NN
cord-006229-7yoilsho	746	13	of	of	IN
cord-006229-7yoilsho	746	14	native	native	JJ
cord-006229-7yoilsho	746	15	TRPM3	TRPM3	NNS
cord-006229-7yoilsho	746	16	channels	channel	NNS
cord-006229-7yoilsho	746	17	.	.	.
cord-006229-7yoilsho	747	1	Consistently	consistently	RB
cord-006229-7yoilsho	747	2	,	,	,
cord-006229-7yoilsho	747	3	primidone	primidone	NNP
cord-006229-7yoilsho	747	4	attenuated	attenuate	VBD
cord-006229-7yoilsho	747	5	nocifensive	nocifensive	JJ
cord-006229-7yoilsho	747	6	responses	response	NNS
cord-006229-7yoilsho	747	7	of	of	IN
cord-006229-7yoilsho	747	8	mice	mouse	NNS
cord-006229-7yoilsho	747	9	to	to	TO
cord-006229-7yoilsho	747	10	paw	paw	NN
cord-006229-7yoilsho	747	11	-	-	HYPH
cord-006229-7yoilsho	747	12	injected	inject	VBN
cord-006229-7yoilsho	747	13	PregS.	PregS.	NNS
cord-006229-7yoilsho	748	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	748	2	,	,	,
cord-006229-7yoilsho	748	3	intraplantar	intraplantar	NNP
cord-006229-7yoilsho	748	4	primidone	primidone	NNP
cord-006229-7yoilsho	748	5	reduced	reduce	VBD
cord-006229-7yoilsho	748	6	nociception	nociception	NN
cord-006229-7yoilsho	748	7	in	in	IN
cord-006229-7yoilsho	748	8	healthy	healthy	JJ
cord-006229-7yoilsho	748	9	and	and	CC
cord-006229-7yoilsho	748	10	hyperalgesic	hyperalgesic	JJ
cord-006229-7yoilsho	748	11	CFA	CFA	NNP
cord-006229-7yoilsho	748	12	-	-	HYPH
cord-006229-7yoilsho	748	13	inflamed	inflame	VBN
cord-006229-7yoilsho	748	14	paws	paw	NNS
cord-006229-7yoilsho	748	15	in	in	IN
cord-006229-7yoilsho	748	16	the	the	DT
cord-006229-7yoilsho	748	17	hot	hot	JJ
cord-006229-7yoilsho	748	18	plate	plate	NN
cord-006229-7yoilsho	748	19	test	test	NN
cord-006229-7yoilsho	748	20	.	.	.
cord-006229-7yoilsho	749	1	The	the	DT
cord-006229-7yoilsho	749	2	finding	finding	NN
cord-006229-7yoilsho	749	3	that	that	IN
cord-006229-7yoilsho	749	4	an	an	DT
cord-006229-7yoilsho	749	5	approved	approve	VBN
cord-006229-7yoilsho	749	6	drug	drug	NN
cord-006229-7yoilsho	749	7	can	can	MD
cord-006229-7yoilsho	749	8	inhibit	inhibit	VB
cord-006229-7yoilsho	749	9	TRPM3	TRPM3	NNS
cord-006229-7yoilsho	749	10	at	at	IN
cord-006229-7yoilsho	749	11	concentrations	concentration	NNS
cord-006229-7yoilsho	749	12	that	that	WDT
cord-006229-7yoilsho	749	13	may	may	MD
cord-006229-7yoilsho	749	14	be	be	VB
cord-006229-7yoilsho	749	15	therapeutically	therapeutically	RB
cord-006229-7yoilsho	749	16	relevant	relevant	JJ
cord-006229-7yoilsho	749	17	and	and	CC
cord-006229-7yoilsho	749	18	thereby	thereby	RB
cord-006229-7yoilsho	749	19	can	can	MD
cord-006229-7yoilsho	749	20	act	act	VB
cord-006229-7yoilsho	749	21	as	as	IN
cord-006229-7yoilsho	749	22	an	an	DT
cord-006229-7yoilsho	749	23	analgesic	analgesic	NN
cord-006229-7yoilsho	749	24	,	,	,
cord-006229-7yoilsho	749	25	provides	provide	VBZ
cord-006229-7yoilsho	749	26	a	a	DT
cord-006229-7yoilsho	749	27	method	method	NN
cord-006229-7yoilsho	749	28	to	to	TO
cord-006229-7yoilsho	749	29	study	study	VB
cord-006229-7yoilsho	749	30	TRPM3-related	trpm3-relate	VBN
cord-006229-7yoilsho	749	31	effects	effect	NNS
cord-006229-7yoilsho	749	32	by	by	IN
cord-006229-7yoilsho	749	33	acutely	acutely	RB
cord-006229-7yoilsho	749	34	challenging	challenge	VBG
cord-006229-7yoilsho	749	35	the	the	DT
cord-006229-7yoilsho	749	36	channel´s	channel´s	NNPS
cord-006229-7yoilsho	749	37	function	function	NN
cord-006229-7yoilsho	749	38	.	.	.
cord-006229-7yoilsho	750	1	Pharmacological	pharmacological	JJ
cord-006229-7yoilsho	750	2	interference	interference	NN
cord-006229-7yoilsho	750	3	with	with	IN
cord-006229-7yoilsho	750	4	TRPM3	TRPM3	NNS
cord-006229-7yoilsho	750	5	applying	apply	VBG
cord-006229-7yoilsho	750	6	an	an	DT
cord-006229-7yoilsho	750	7	approved	approve	VBN
cord-006229-7yoilsho	750	8	drug	drug	NN
cord-006229-7yoilsho	750	9	or	or	CC
cord-006229-7yoilsho	750	10	optimised	optimise	VBN
cord-006229-7yoilsho	750	11	successor	successor	NN
cord-006229-7yoilsho	750	12	compounds	compound	NNS
cord-006229-7yoilsho	750	13	may	may	MD
cord-006229-7yoilsho	750	14	pave	pave	VB
cord-006229-7yoilsho	750	15	the	the	DT
cord-006229-7yoilsho	750	16	way	way	NN
cord-006229-7yoilsho	750	17	to	to	IN
cord-006229-7yoilsho	750	18	better	well	JJR
cord-006229-7yoilsho	750	19	understanding	understanding	NN
cord-006229-7yoilsho	750	20	of	of	IN
cord-006229-7yoilsho	750	21	physiological	physiological	JJ
cord-006229-7yoilsho	750	22	functions	function	NNS
cord-006229-7yoilsho	750	23	of	of	IN
cord-006229-7yoilsho	750	24	TRPM3	TRPM3	NNS
cord-006229-7yoilsho	750	25	in	in	IN
cord-006229-7yoilsho	750	26	humans	human	NNS
cord-006229-7yoilsho	750	27	and	and	CC
cord-006229-7yoilsho	750	28	may	may	MD
cord-006229-7yoilsho	750	29	represent	represent	VB
cord-006229-7yoilsho	750	30	a	a	DT
cord-006229-7yoilsho	750	31	novel	novel	JJ
cord-006229-7yoilsho	750	32	concept	concept	NN
cord-006229-7yoilsho	750	33	for	for	IN
cord-006229-7yoilsho	750	34	analgesic	analgesic	JJ
cord-006229-7yoilsho	750	35	treatment	treatment	NN
cord-006229-7yoilsho	750	36	.	.	.
cord-006229-7yoilsho	751	1	Excitotoxicity	excitotoxicity	NN
cord-006229-7yoilsho	751	2	,	,	,
cord-006229-7yoilsho	751	3	calcium	calcium	NN
cord-006229-7yoilsho	751	4	deregulation	deregulation	NN
cord-006229-7yoilsho	751	5	,	,	,
cord-006229-7yoilsho	751	6	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	751	7	dysfunction	dysfunction	NN
cord-006229-7yoilsho	751	8	and	and	CC
cord-006229-7yoilsho	751	9	neuroinflammation	neuroinflammation	NN
cord-006229-7yoilsho	751	10	contribute	contribute	VB
cord-006229-7yoilsho	751	11	to	to	IN
cord-006229-7yoilsho	751	12	progressive	progressive	JJ
cord-006229-7yoilsho	751	13	cell	cell	NN
cord-006229-7yoilsho	751	14	death	death	NN
cord-006229-7yoilsho	751	15	in	in	IN
cord-006229-7yoilsho	751	16	many	many	JJ
cord-006229-7yoilsho	751	17	neurodegenerative	neurodegenerative	JJ
cord-006229-7yoilsho	751	18	diseases	disease	NNS
cord-006229-7yoilsho	751	19	.	.	.
cord-006229-7yoilsho	752	1	Therefore	therefore	RB
cord-006229-7yoilsho	752	2	,	,	,
cord-006229-7yoilsho	752	3	proteins	protein	NNS
cord-006229-7yoilsho	752	4	that	that	WDT
cord-006229-7yoilsho	752	5	prevent	prevent	VBP
cord-006229-7yoilsho	752	6	deregulation	deregulation	NN
cord-006229-7yoilsho	752	7	of	of	IN
cord-006229-7yoilsho	752	8	these	these	DT
cord-006229-7yoilsho	752	9	pathways	pathway	NNS
cord-006229-7yoilsho	752	10	are	be	VBP
cord-006229-7yoilsho	752	11	considered	consider	VBN
cord-006229-7yoilsho	752	12	as	as	IN
cord-006229-7yoilsho	752	13	drug	drug	NN
cord-006229-7yoilsho	752	14	targets	target	NNS
cord-006229-7yoilsho	752	15	.	.	.
cord-006229-7yoilsho	753	1	Potential	potential	JJ
cord-006229-7yoilsho	753	2	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	753	3	approaches	approach	NNS
cord-006229-7yoilsho	753	4	may	may	MD
cord-006229-7yoilsho	753	5	benefit	benefit	VB
cord-006229-7yoilsho	753	6	from	from	IN
cord-006229-7yoilsho	753	7	modulation	modulation	NN
cord-006229-7yoilsho	753	8	of	of	IN
cord-006229-7yoilsho	753	9	small	small	JJ
cord-006229-7yoilsho	753	10	-	-	HYPH
cord-006229-7yoilsho	753	11	conductance	conductance	NN
cord-006229-7yoilsho	753	12	calcium	calcium	NN
cord-006229-7yoilsho	753	13	-	-	HYPH
cord-006229-7yoilsho	753	14	activated	activate	VBN
cord-006229-7yoilsho	753	15	potassium	potassium	NN
cord-006229-7yoilsho	753	16	(	(	-LRB-
cord-006229-7yoilsho	753	17	SK	SK	NNP
cord-006229-7yoilsho	753	18	)	)	-RRB-
cord-006229-7yoilsho	753	19	channels	channel	NNS
cord-006229-7yoilsho	753	20	,	,	,
cord-006229-7yoilsho	753	21	since	since	IN
cord-006229-7yoilsho	753	22	recent	recent	JJ
cord-006229-7yoilsho	753	23	data	data	NN
cord-006229-7yoilsho	753	24	supports	support	VBZ
cord-006229-7yoilsho	753	25	the	the	DT
cord-006229-7yoilsho	753	26	hypothesis	hypothesis	NN
cord-006229-7yoilsho	753	27	that	that	IN
cord-006229-7yoilsho	753	28	SK	SK	NNP
cord-006229-7yoilsho	753	29	channel	channel	NN
cord-006229-7yoilsho	753	30	activity	activity	NN
cord-006229-7yoilsho	753	31	promotes	promote	VBZ
cord-006229-7yoilsho	753	32	neuronal	neuronal	JJ
cord-006229-7yoilsho	753	33	survival	survival	NN
cord-006229-7yoilsho	753	34	against	against	IN
cord-006229-7yoilsho	753	35	cellular	cellular	JJ
cord-006229-7yoilsho	753	36	stress	stress	NN
cord-006229-7yoilsho	753	37	via	via	IN
cord-006229-7yoilsho	753	38	a	a	DT
cord-006229-7yoilsho	753	39	dual	dual	JJ
cord-006229-7yoilsho	753	40	mechanism	mechanism	NN
cord-006229-7yoilsho	753	41	of	of	IN
cord-006229-7yoilsho	753	42	action	action	NN
cord-006229-7yoilsho	753	43	:	:	:
cord-006229-7yoilsho	753	44	i	i	LS
cord-006229-7yoilsho	753	45	)	)	-RRB-
cord-006229-7yoilsho	753	46	by	by	IN
cord-006229-7yoilsho	753	47	controlling	control	VBG
cord-006229-7yoilsho	753	48	neuronal	neuronal	JJ
cord-006229-7yoilsho	753	49	excitability	excitability	NN
cord-006229-7yoilsho	753	50	and	and	CC
cord-006229-7yoilsho	753	51	ii	ii	NN
cord-006229-7yoilsho	753	52	)	)	-RRB-
cord-006229-7yoilsho	753	53	by	by	IN
cord-006229-7yoilsho	753	54	preventing	prevent	VBG
cord-006229-7yoilsho	753	55	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	753	56	dysfunction	dysfunction	NN
cord-006229-7yoilsho	753	57	and	and	CC
cord-006229-7yoilsho	753	58	inflammation	inflammation	NN
cord-006229-7yoilsho	753	59	.	.	.
cord-006229-7yoilsho	754	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	754	2	previous	previous	JJ
cord-006229-7yoilsho	754	3	studies	study	NNS
cord-006229-7yoilsho	754	4	showed	show	VBD
cord-006229-7yoilsho	754	5	that	that	IN
cord-006229-7yoilsho	754	6	activation	activation	NN
cord-006229-7yoilsho	754	7	of	of	IN
cord-006229-7yoilsho	754	8	SK	SK	NNP
cord-006229-7yoilsho	754	9	channels	channel	NNS
cord-006229-7yoilsho	754	10	in	in	IN
cord-006229-7yoilsho	754	11	neurons	neuron	NNS
cord-006229-7yoilsho	754	12	exerted	exert	VBD
cord-006229-7yoilsho	754	13	protective	protective	JJ
cord-006229-7yoilsho	754	14	effects	effect	NNS
cord-006229-7yoilsho	754	15	through	through	IN
cord-006229-7yoilsho	754	16	inhibition	inhibition	NN
cord-006229-7yoilsho	754	17	of	of	IN
cord-006229-7yoilsho	754	18	NMDARmediated	nmdarmediate	VBN
cord-006229-7yoilsho	754	19	excitotoxicity	excitotoxicity	NN
cord-006229-7yoilsho	754	20	.	.	.
cord-006229-7yoilsho	755	1	Further	further	RB
cord-006229-7yoilsho	755	2	,	,	,
cord-006229-7yoilsho	755	3	we	-PRON-	PRP
cord-006229-7yoilsho	755	4	revealed	reveal	VBD
cord-006229-7yoilsho	755	5	recently	recently	RB
cord-006229-7yoilsho	755	6	that	that	IN
cord-006229-7yoilsho	755	7	in	in	IN
cord-006229-7yoilsho	755	8	a	a	DT
cord-006229-7yoilsho	755	9	model	model	NN
cord-006229-7yoilsho	755	10	of	of	IN
cord-006229-7yoilsho	755	11	glutamate	glutamate	NN
cord-006229-7yoilsho	755	12	oxytosis	oxytosis	NN
cord-006229-7yoilsho	755	13	,	,	,
cord-006229-7yoilsho	755	14	activation	activation	NN
cord-006229-7yoilsho	755	15	of	of	IN
cord-006229-7yoilsho	755	16	SK	SK	NNP
cord-006229-7yoilsho	755	17	channels	channel	NNS
cord-006229-7yoilsho	755	18	attenuated	attenuate	VBN
cord-006229-7yoilsho	755	19	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	755	20	fission	fission	NN
cord-006229-7yoilsho	755	21	,	,	,
cord-006229-7yoilsho	755	22	prevented	prevent	VBD
cord-006229-7yoilsho	755	23	the	the	DT
cord-006229-7yoilsho	755	24	release	release	NN
cord-006229-7yoilsho	755	25	of	of	IN
cord-006229-7yoilsho	755	26	pro	pro	JJ
cord-006229-7yoilsho	755	27	-	-	JJ
cord-006229-7yoilsho	755	28	apoptotic	apoptotic	JJ
cord-006229-7yoilsho	755	29	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	755	30	proteins	protein	NNS
cord-006229-7yoilsho	755	31	,	,	,
cord-006229-7yoilsho	755	32	and	and	CC
cord-006229-7yoilsho	755	33	reduced	reduced	JJ
cord-006229-7yoilsho	755	34	cell	cell	NN
cord-006229-7yoilsho	755	35	death	death	NN
cord-006229-7yoilsho	755	36	.	.	.
cord-006229-7yoilsho	756	1	However	however	RB
cord-006229-7yoilsho	756	2	,	,	,
cord-006229-7yoilsho	756	3	little	little	JJ
cord-006229-7yoilsho	756	4	is	be	VBZ
cord-006229-7yoilsho	756	5	known	know	VBN
cord-006229-7yoilsho	756	6	about	about	IN
cord-006229-7yoilsho	756	7	the	the	DT
cord-006229-7yoilsho	756	8	function	function	NN
cord-006229-7yoilsho	756	9	of	of	IN
cord-006229-7yoilsho	756	10	SK	SK	NNP
cord-006229-7yoilsho	756	11	channels	channel	NNS
cord-006229-7yoilsho	756	12	in	in	IN
cord-006229-7yoilsho	756	13	cell	cell	NN
cord-006229-7yoilsho	756	14	metabolism	metabolism	NN
cord-006229-7yoilsho	756	15	and	and	CC
cord-006229-7yoilsho	756	16	neuroinflammatory	neuroinflammatory	NN
cord-006229-7yoilsho	756	17	processes	process	NNS
cord-006229-7yoilsho	756	18	in	in	IN
cord-006229-7yoilsho	756	19	non	non	JJ
cord-006229-7yoilsho	756	20	-	-	JJ
cord-006229-7yoilsho	756	21	neuronal	neuronal	JJ
cord-006229-7yoilsho	756	22	cells	cell	NNS
cord-006229-7yoilsho	756	23	,	,	,
cord-006229-7yoilsho	756	24	such	such	JJ
cord-006229-7yoilsho	756	25	as	as	IN
cord-006229-7yoilsho	756	26	microglial	microglial	JJ
cord-006229-7yoilsho	756	27	cells	cell	NNS
cord-006229-7yoilsho	756	28	.	.	.
cord-006229-7yoilsho	757	1	In	in	IN
cord-006229-7yoilsho	757	2	this	this	DT
cord-006229-7yoilsho	757	3	study	study	NN
cord-006229-7yoilsho	757	4	,	,	,
cord-006229-7yoilsho	757	5	we	-PRON-	PRP
cord-006229-7yoilsho	757	6	addressed	address	VBD
cord-006229-7yoilsho	757	7	the	the	DT
cord-006229-7yoilsho	757	8	question	question	NN
cord-006229-7yoilsho	757	9	whether	whether	IN
cord-006229-7yoilsho	757	10	SK	SK	NNP
cord-006229-7yoilsho	757	11	channel	channel	NN
cord-006229-7yoilsho	757	12	activation	activation	NN
cord-006229-7yoilsho	757	13	affected	affect	VBN
cord-006229-7yoilsho	757	14	primary	primary	JJ
cord-006229-7yoilsho	757	15	mouse	mouse	NN
cord-006229-7yoilsho	757	16	microglia	microglia	NN
cord-006229-7yoilsho	757	17	activation	activation	NN
cord-006229-7yoilsho	757	18	upon	upon	IN
cord-006229-7yoilsho	757	19	LPS	LPS	NNP
cord-006229-7yoilsho	757	20	and	and	CC
cord-006229-7yoilsho	757	21	α	α	NNP
cord-006229-7yoilsho	757	22	-	-	HYPH
cord-006229-7yoilsho	757	23	synuclein	synuclein	NN
cord-006229-7yoilsho	757	24	challenge	challenge	NN
cord-006229-7yoilsho	757	25	.	.	.
cord-006229-7yoilsho	758	1	We	-PRON-	PRP
cord-006229-7yoilsho	758	2	found	find	VBD
cord-006229-7yoilsho	758	3	that	that	DT
cord-006229-7yoilsho	758	4	activation	activation	NN
cord-006229-7yoilsho	758	5	of	of	IN
cord-006229-7yoilsho	758	6	SK	SK	NNP
cord-006229-7yoilsho	758	7	channels	channel	NNS
cord-006229-7yoilsho	758	8	significantly	significantly	RB
cord-006229-7yoilsho	758	9	reduced	reduce	VBN
cord-006229-7yoilsho	758	10	activation	activation	NN
cord-006229-7yoilsho	758	11	of	of	IN
cord-006229-7yoilsho	758	12	microglia	microglia	NN
cord-006229-7yoilsho	758	13	in	in	IN
cord-006229-7yoilsho	758	14	a	a	DT
cord-006229-7yoilsho	758	15	concentration	concentration	NN
cord-006229-7yoilsho	758	16	-	-	HYPH
cord-006229-7yoilsho	758	17	dependent	dependent	JJ
cord-006229-7yoilsho	758	18	manner	manner	NN
cord-006229-7yoilsho	758	19	,	,	,
cord-006229-7yoilsho	758	20	as	as	IN
cord-006229-7yoilsho	758	21	detected	detect	VBN
cord-006229-7yoilsho	758	22	by	by	IN
cord-006229-7yoilsho	758	23	real	real	JJ
cord-006229-7yoilsho	758	24	-	-	HYPH
cord-006229-7yoilsho	758	25	time	time	NN
cord-006229-7yoilsho	758	26	xCELLigence	xcelligence	NN
cord-006229-7yoilsho	758	27	cell	cell	NN
cord-006229-7yoilsho	758	28	impedance	impedance	NN
cord-006229-7yoilsho	758	29	measurements	measurement	NNS
cord-006229-7yoilsho	758	30	.	.	.
cord-006229-7yoilsho	759	1	Further	further	JJ
cord-006229-7yoilsho	759	2	data	datum	NNS
cord-006229-7yoilsho	759	3	on	on	IN
cord-006229-7yoilsho	759	4	cytokine	cytokine	NN
cord-006229-7yoilsho	759	5	(	(	-LRB-
cord-006229-7yoilsho	759	6	TNF	tnf	NN
cord-006229-7yoilsho	759	7	-	-	HYPH
cord-006229-7yoilsho	759	8	alpha	alpha	NN
cord-006229-7yoilsho	759	9	and	and	CC
cord-006229-7yoilsho	759	10	IL-6	IL-6	NNP
cord-006229-7yoilsho	759	11	)	)	-RRB-
cord-006229-7yoilsho	759	12	analysis	analysis	NN
cord-006229-7yoilsho	759	13	revealed	reveal	VBD
cord-006229-7yoilsho	759	14	that	that	IN
cord-006229-7yoilsho	759	15	activation	activation	NN
cord-006229-7yoilsho	759	16	of	of	IN
cord-006229-7yoilsho	759	17	SK	SK	NNP
cord-006229-7yoilsho	759	18	channels	channel	NNS
cord-006229-7yoilsho	759	19	attenuated	attenuate	VBD
cord-006229-7yoilsho	759	20	α	α	NNP
cord-006229-7yoilsho	759	21	-	-	HYPH
cord-006229-7yoilsho	759	22	synuclein	synuclein	NN
cord-006229-7yoilsho	759	23	-	-	HYPH
cord-006229-7yoilsho	759	24	induced	induce	VBN
cord-006229-7yoilsho	759	25	cytokine	cytokine	NN
cord-006229-7yoilsho	759	26	release	release	NN
cord-006229-7yoilsho	759	27	.	.	.
cord-006229-7yoilsho	760	1	Inhibition	inhibition	NN
cord-006229-7yoilsho	760	2	of	of	IN
cord-006229-7yoilsho	760	3	glycolysis	glycolysis	NN
cord-006229-7yoilsho	760	4	prevented	prevent	VBD
cord-006229-7yoilsho	760	5	microglial	microglial	JJ
cord-006229-7yoilsho	760	6	activation	activation	NN
cord-006229-7yoilsho	760	7	and	and	CC
cord-006229-7yoilsho	760	8	cytokine	cytokine	NN
cord-006229-7yoilsho	760	9	release	release	NN
cord-006229-7yoilsho	760	10	.	.	.
cord-006229-7yoilsho	761	1	Although	although	IN
cord-006229-7yoilsho	761	2	SK	SK	NNP
cord-006229-7yoilsho	761	3	channel	channel	NN
cord-006229-7yoilsho	761	4	activation	activation	NN
cord-006229-7yoilsho	761	5	slightly	slightly	RB
cord-006229-7yoilsho	761	6	reduced	reduce	VBN
cord-006229-7yoilsho	761	7	ATP	ATP	NNP
cord-006229-7yoilsho	761	8	levels	level	NNS
cord-006229-7yoilsho	761	9	,	,	,
cord-006229-7yoilsho	761	10	it	-PRON-	PRP
cord-006229-7yoilsho	761	11	attenuated	attenuate	VBD
cord-006229-7yoilsho	761	12	α	α	NNP
cord-006229-7yoilsho	761	13	-	-	HYPH
cord-006229-7yoilsho	761	14	synuclein	synuclein	NN
cord-006229-7yoilsho	761	15	-	-	HYPH
cord-006229-7yoilsho	761	16	induced	induce	VBN
cord-006229-7yoilsho	761	17	NO	no	DT
cord-006229-7yoilsho	761	18	release	release	NN
cord-006229-7yoilsho	761	19	.	.	.
cord-006229-7yoilsho	762	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	762	2	,	,	,
cord-006229-7yoilsho	762	3	glycolytic	glycolytic	JJ
cord-006229-7yoilsho	762	4	products	product	NNS
cord-006229-7yoilsho	762	5	and	and	CC
cord-006229-7yoilsho	762	6	AMPK	AMPK	NNP
cord-006229-7yoilsho	762	7	signaling	signal	VBG
cord-006229-7yoilsho	762	8	were	be	VBD
cord-006229-7yoilsho	762	9	evaluated	evaluate	VBN
cord-006229-7yoilsho	762	10	.	.	.
cord-006229-7yoilsho	763	1	Overall	overall	RB
cord-006229-7yoilsho	763	2	,	,	,
cord-006229-7yoilsho	763	3	our	-PRON-	PRP$
cord-006229-7yoilsho	763	4	findings	finding	NNS
cord-006229-7yoilsho	763	5	show	show	VBP
cord-006229-7yoilsho	763	6	that	that	IN
cord-006229-7yoilsho	763	7	activation	activation	NN
cord-006229-7yoilsho	763	8	of	of	IN
cord-006229-7yoilsho	763	9	SK	SK	NNP
cord-006229-7yoilsho	763	10	channels	channel	NNS
cord-006229-7yoilsho	763	11	attenuates	attenuate	VBZ
cord-006229-7yoilsho	763	12	microglial	microglial	JJ
cord-006229-7yoilsho	763	13	cell	cell	NN
cord-006229-7yoilsho	763	14	activation	activation	NN
cord-006229-7yoilsho	763	15	.	.	.
cord-006229-7yoilsho	764	1	Thus	thus	RB
cord-006229-7yoilsho	764	2	,	,	,
cord-006229-7yoilsho	764	3	SK	SK	NNP
cord-006229-7yoilsho	764	4	channels	channel	NNS
cord-006229-7yoilsho	764	5	are	be	VBP
cord-006229-7yoilsho	764	6	promising	promise	VBG
cord-006229-7yoilsho	764	7	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	764	8	targets	target	NNS
cord-006229-7yoilsho	764	9	for	for	IN
cord-006229-7yoilsho	764	10	neurodegenerative	neurodegenerative	JJ
cord-006229-7yoilsho	764	11	disorders	disorder	NNS
cord-006229-7yoilsho	764	12	,	,	,
cord-006229-7yoilsho	764	13	where	where	WRB
cord-006229-7yoilsho	764	14	neuroinflammation	neuroinflammation	NN
cord-006229-7yoilsho	764	15	and	and	CC
cord-006229-7yoilsho	764	16	cell	cell	NN
cord-006229-7yoilsho	764	17	metabolic	metabolic	JJ
cord-006229-7yoilsho	764	18	deregulation	deregulation	NN
cord-006229-7yoilsho	764	19	are	be	VBP
cord-006229-7yoilsho	764	20	associated	associate	VBN
cord-006229-7yoilsho	764	21	with	with	IN
cord-006229-7yoilsho	764	22	progression	progression	NN
cord-006229-7yoilsho	764	23	of	of	IN
cord-006229-7yoilsho	764	24	the	the	DT
cord-006229-7yoilsho	764	25	disease	disease	NN
cord-006229-7yoilsho	764	26	.	.	.
cord-006229-7yoilsho	765	1	mutant	mutant	JJ
cord-006229-7yoilsho	765	2	of	of	IN
cord-006229-7yoilsho	765	3	the	the	DT
cord-006229-7yoilsho	765	4	residue	residue	NN
cord-006229-7yoilsho	765	5	pair	pair	NN
cord-006229-7yoilsho	765	6	E103	E103	NNP
cord-006229-7yoilsho	765	7	/	/	SYM
cord-006229-7yoilsho	765	8	K308	k308	PRP
cord-006229-7yoilsho	765	9	can	can	MD
cord-006229-7yoilsho	765	10	be	be	VB
cord-006229-7yoilsho	765	11	crosslinked	crosslinke	VBN
cord-006229-7yoilsho	765	12	efficiently	efficiently	RB
cord-006229-7yoilsho	765	13	in	in	IN
cord-006229-7yoilsho	765	14	both	both	DT
cord-006229-7yoilsho	765	15	states	state	NNS
cord-006229-7yoilsho	765	16	,	,	,
cord-006229-7yoilsho	765	17	the	the	DT
cord-006229-7yoilsho	765	18	closed	close	VBN
cord-006229-7yoilsho	765	19	-	-	HYPH
cord-006229-7yoilsho	765	20	and	and	CC
cord-006229-7yoilsho	765	21	open	open	JJ
cord-006229-7yoilsho	765	22	state	state	NN
cord-006229-7yoilsho	765	23	of	of	IN
cord-006229-7yoilsho	765	24	the	the	DT
cord-006229-7yoilsho	765	25	P2X2R.	P2X2R.	NNP
cord-006229-7yoilsho	766	1	Interestingly	interestingly	RB
cord-006229-7yoilsho	766	2	,	,	,
cord-006229-7yoilsho	766	3	oxidative	oxidative	JJ
cord-006229-7yoilsho	766	4	crosslinking	crosslinking	NN
cord-006229-7yoilsho	766	5	of	of	IN
cord-006229-7yoilsho	766	6	cysteine	cysteine	NN
cord-006229-7yoilsho	766	7	substitution	substitution	NN
cord-006229-7yoilsho	766	8	mutants	mutant	NNS
cord-006229-7yoilsho	766	9	of	of	IN
cord-006229-7yoilsho	766	10	each	each	DT
cord-006229-7yoilsho	766	11	individual	individual	JJ
cord-006229-7yoilsho	766	12	residue	residue	NN
cord-006229-7yoilsho	766	13	pair	pair	NN
cord-006229-7yoilsho	766	14	significantly	significantly	RB
cord-006229-7yoilsho	766	15	reduced	reduce	VBD
cord-006229-7yoilsho	766	16	the	the	DT
cord-006229-7yoilsho	766	17	ATPinduced	atpinduce	VBN
cord-006229-7yoilsho	766	18	current	current	JJ
cord-006229-7yoilsho	766	19	amplitudes	amplitude	NNS
cord-006229-7yoilsho	766	20	.	.	.
cord-006229-7yoilsho	767	1	Charge	charge	NN
cord-006229-7yoilsho	767	2	reversal	reversal	NN
cord-006229-7yoilsho	767	3	or	or	CC
cord-006229-7yoilsho	767	4	swapping	swapping	NN
cord-006229-7yoilsho	767	5	mutagenesis	mutagenesis	NN
cord-006229-7yoilsho	767	6	and	and	CC
cord-006229-7yoilsho	767	7	cysteine	cysteine	NN
cord-006229-7yoilsho	767	8	modification	modification	NN
cord-006229-7yoilsho	767	9	by	by	IN
cord-006229-7yoilsho	767	10	charged	charge	VBN
cord-006229-7yoilsho	767	11	MTS	MTS	NNP
cord-006229-7yoilsho	767	12	-	-	HYPH
cord-006229-7yoilsho	767	13	reagents	reagent	NNS
cord-006229-7yoilsho	767	14	indicated	indicate	VBD
cord-006229-7yoilsho	767	15	the	the	DT
cord-006229-7yoilsho	767	16	electrostatic	electrostatic	JJ
cord-006229-7yoilsho	767	17	nature	nature	NN
cord-006229-7yoilsho	767	18	of	of	IN
cord-006229-7yoilsho	767	19	the	the	DT
cord-006229-7yoilsho	767	20	pairwise	pairwise	JJ
cord-006229-7yoilsho	767	21	interactions	interaction	NNS
cord-006229-7yoilsho	767	22	in	in	IN
cord-006229-7yoilsho	767	23	these	these	DT
cord-006229-7yoilsho	767	24	four	four	CD
cord-006229-7yoilsho	767	25	residue	residue	NN
cord-006229-7yoilsho	767	26	pairs	pair	NNS
cord-006229-7yoilsho	767	27	.	.	.
cord-006229-7yoilsho	768	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	768	2	,	,	,
cord-006229-7yoilsho	768	3	preliminary	preliminary	JJ
cord-006229-7yoilsho	768	4	data	datum	NNS
cord-006229-7yoilsho	768	5	from	from	IN
cord-006229-7yoilsho	768	6	triple	triple	JJ
cord-006229-7yoilsho	768	7	,	,	,
cord-006229-7yoilsho	768	8	tetra	tetra	NNP
cord-006229-7yoilsho	768	9	and	and	CC
cord-006229-7yoilsho	768	10	penta	penta	NNP
cord-006229-7yoilsho	768	11	mutant	mutant	NNP
cord-006229-7yoilsho	768	12	cycle	cycle	NN
cord-006229-7yoilsho	768	13	analysis	analysis	NN
cord-006229-7yoilsho	768	14	indicated	indicate	VBD
cord-006229-7yoilsho	768	15	energetic	energetic	JJ
cord-006229-7yoilsho	768	16	coupling	coupling	NN
cord-006229-7yoilsho	768	17	between	between	IN
cord-006229-7yoilsho	768	18	the	the	DT
cord-006229-7yoilsho	768	19	residue	residue	NN
cord-006229-7yoilsho	768	20	pairs	pair	NNS
cord-006229-7yoilsho	768	21	E84	E84	NNP
cord-006229-7yoilsho	768	22	/	/	SYM
cord-006229-7yoilsho	768	23	R290	R290	NNPS
cord-006229-7yoilsho	768	24	,	,	,
cord-006229-7yoilsho	768	25	E103	E103	NNP
cord-006229-7yoilsho	768	26	/	/	SYM
cord-006229-7yoilsho	768	27	K308	k308	CD
cord-006229-7yoilsho	768	28	,	,	,
cord-006229-7yoilsho	768	29	E167	e167	CD
cord-006229-7yoilsho	768	30	/	/	SYM
cord-006229-7yoilsho	768	31	R290	R290	NNPS
cord-006229-7yoilsho	768	32	and	and	CC
cord-006229-7yoilsho	768	33	E167	e167	CD
cord-006229-7yoilsho	768	34	/	/	SYM
cord-006229-7yoilsho	768	35	K308	k308	CD
cord-006229-7yoilsho	768	36	and	and	CC
cord-006229-7yoilsho	768	37	thus	thus	RB
cord-006229-7yoilsho	768	38	indicates	indicate	VBZ
cord-006229-7yoilsho	768	39	the	the	DT
cord-006229-7yoilsho	768	40	cooperative	cooperative	JJ
cord-006229-7yoilsho	768	41	interaction	interaction	NN
cord-006229-7yoilsho	768	42	in	in	IN
cord-006229-7yoilsho	768	43	a	a	DT
cord-006229-7yoilsho	768	44	larger	large	JJR
cord-006229-7yoilsho	768	45	salt	salt	NN
cord-006229-7yoilsho	768	46	bridge	bridge	NN
cord-006229-7yoilsho	768	47	network	network	NN
cord-006229-7yoilsho	768	48	.	.	.
cord-006229-7yoilsho	769	1	Together	together	RB
cord-006229-7yoilsho	769	2	with	with	IN
cord-006229-7yoilsho	769	3	the	the	DT
cord-006229-7yoilsho	769	4	markedly	markedly	RB
cord-006229-7yoilsho	769	5	reduced	reduce	VBN
cord-006229-7yoilsho	769	6	current	current	JJ
cord-006229-7yoilsho	769	7	amplitudes	amplitude	NNS
cord-006229-7yoilsho	769	8	following	follow	VBG
cord-006229-7yoilsho	769	9	disulfide	disulfide	NN
cord-006229-7yoilsho	769	10	crosslinking	crosslinking	NN
cord-006229-7yoilsho	769	11	,	,	,
cord-006229-7yoilsho	769	12	our	-PRON-	PRP$
cord-006229-7yoilsho	769	13	data	datum	NNS
cord-006229-7yoilsho	769	14	suggest	suggest	VBP
cord-006229-7yoilsho	769	15	that	that	IN
cord-006229-7yoilsho	769	16	the	the	DT
cord-006229-7yoilsho	769	17	salt	salt	NN
cord-006229-7yoilsho	769	18	bridge	bridge	NNP
cord-006229-7yoilsho	769	19	network	network	NN
cord-006229-7yoilsho	769	20	serves	serve	VBZ
cord-006229-7yoilsho	769	21	to	to	TO
cord-006229-7yoilsho	769	22	stabilize	stabilize	VB
cord-006229-7yoilsho	769	23	the	the	DT
cord-006229-7yoilsho	769	24	closed	closed	JJ
cord-006229-7yoilsho	769	25	-	-	HYPH
cord-006229-7yoilsho	769	26	state	state	NN
cord-006229-7yoilsho	769	27	conformation	conformation	NN
cord-006229-7yoilsho	769	28	of	of	IN
cord-006229-7yoilsho	769	29	the	the	DT
cord-006229-7yoilsho	769	30	P2X2R.	P2X2R.	NNP
cord-006229-7yoilsho	770	1	The	the	DT
cord-006229-7yoilsho	770	2	comparison	comparison	NN
cord-006229-7yoilsho	770	3	of	of	IN
cord-006229-7yoilsho	770	4	the	the	DT
cord-006229-7yoilsho	770	5	closed	closed	JJ
cord-006229-7yoilsho	770	6	-	-	HYPH
cord-006229-7yoilsho	770	7	state	state	NN
cord-006229-7yoilsho	770	8	and	and	CC
cord-006229-7yoilsho	770	9	open	open	JJ
cord-006229-7yoilsho	770	10	-	-	HYPH
cord-006229-7yoilsho	770	11	state	state	NN
cord-006229-7yoilsho	770	12	model	model	NN
cord-006229-7yoilsho	770	13	of	of	IN
cord-006229-7yoilsho	770	14	the	the	DT
cord-006229-7yoilsho	770	15	rat	rat	NN
cord-006229-7yoilsho	770	16	P2X2R	P2X2R	NNP
cord-006229-7yoilsho	770	17	showed	show	VBD
cord-006229-7yoilsho	770	18	that	that	IN
cord-006229-7yoilsho	770	19	ATP	ATP	NNP
cord-006229-7yoilsho	770	20	promotes	promote	VBZ
cord-006229-7yoilsho	770	21	a	a	DT
cord-006229-7yoilsho	770	22	marked	marked	JJ
cord-006229-7yoilsho	770	23	rearrangement	rearrangement	NN
cord-006229-7yoilsho	770	24	of	of	IN
cord-006229-7yoilsho	770	25	the	the	DT
cord-006229-7yoilsho	770	26	side	side	NN
cord-006229-7yoilsho	770	27	chains	chain	NNS
cord-006229-7yoilsho	770	28	of	of	IN
cord-006229-7yoilsho	770	29	the	the	DT
cord-006229-7yoilsho	770	30	residues	residue	NNS
cord-006229-7yoilsho	770	31	R290	R290	NNPS
cord-006229-7yoilsho	770	32	and	and	CC
cord-006229-7yoilsho	770	33	K308	K308	NNS
cord-006229-7yoilsho	770	34	to	to	TO
cord-006229-7yoilsho	770	35	enable	enable	VB
cord-006229-7yoilsho	770	36	the	the	DT
cord-006229-7yoilsho	770	37	strong	strong	JJ
cord-006229-7yoilsho	770	38	ionic	ionic	JJ
cord-006229-7yoilsho	770	39	coordination	coordination	NN
cord-006229-7yoilsho	770	40	of	of	IN
cord-006229-7yoilsho	770	41	the	the	DT
cord-006229-7yoilsho	770	42	γ	γ	NN
cord-006229-7yoilsho	770	43	-	-	HYPH
cord-006229-7yoilsho	770	44	phosphate	phosphate	NN
cord-006229-7yoilsho	770	45	oxygen	oxygen	NN
cord-006229-7yoilsho	770	46	of	of	IN
cord-006229-7yoilsho	770	47	ATP	ATP	NNP
cord-006229-7yoilsho	770	48	.	.	.
cord-006229-7yoilsho	771	1	In	in	IN
cord-006229-7yoilsho	771	2	summary	summary	NN
cord-006229-7yoilsho	771	3	,	,	,
cord-006229-7yoilsho	771	4	our	-PRON-	PRP$
cord-006229-7yoilsho	771	5	data	datum	NNS
cord-006229-7yoilsho	771	6	are	be	VBP
cord-006229-7yoilsho	771	7	in	in	IN
cord-006229-7yoilsho	771	8	line	line	NN
cord-006229-7yoilsho	771	9	with	with	IN
cord-006229-7yoilsho	771	10	the	the	DT
cord-006229-7yoilsho	771	11	concept	concept	NN
cord-006229-7yoilsho	771	12	that	that	IN
cord-006229-7yoilsho	771	13	the	the	DT
cord-006229-7yoilsho	771	14	electrostatic	electrostatic	JJ
cord-006229-7yoilsho	771	15	interaction	interaction	NN
cord-006229-7yoilsho	771	16	of	of	IN
cord-006229-7yoilsho	771	17	R290	R290	NNPS
cord-006229-7yoilsho	771	18	and	and	CC
cord-006229-7yoilsho	771	19	K308	k308	CD
cord-006229-7yoilsho	771	20	with	with	IN
cord-006229-7yoilsho	771	21	ATP	ATP	NNP
cord-006229-7yoilsho	771	22	competitively	competitively	RB
cord-006229-7yoilsho	771	23	releases	release	VBZ
cord-006229-7yoilsho	771	24	E84	E84	NNP
cord-006229-7yoilsho	771	25	,	,	,
cord-006229-7yoilsho	771	26	E103	E103	NNP
cord-006229-7yoilsho	771	27	and	and	CC
cord-006229-7yoilsho	771	28	E167	E167	NNPS
cord-006229-7yoilsho	771	29	from	from	IN
cord-006229-7yoilsho	771	30	their	-PRON-	PRP$
cord-006229-7yoilsho	771	31	strong	strong	JJ
cord-006229-7yoilsho	771	32	electrostatic	electrostatic	JJ
cord-006229-7yoilsho	771	33	coupling	coupling	NN
cord-006229-7yoilsho	771	34	and	and	CC
cord-006229-7yoilsho	771	35	thus	thus	RB
cord-006229-7yoilsho	771	36	initiates	initiate	VBZ
cord-006229-7yoilsho	771	37	a	a	DT
cord-006229-7yoilsho	771	38	destabilization	destabilization	NN
cord-006229-7yoilsho	771	39	of	of	IN
cord-006229-7yoilsho	771	40	the	the	DT
cord-006229-7yoilsho	771	41	closed	closed	JJ
cord-006229-7yoilsho	771	42	-	-	HYPH
cord-006229-7yoilsho	771	43	state	state	NN
cord-006229-7yoilsho	771	44	,	,	,
cord-006229-7yoilsho	771	45	which	which	WDT
cord-006229-7yoilsho	771	46	favors	favor	VBZ
cord-006229-7yoilsho	771	47	channel	channel	NN
cord-006229-7yoilsho	771	48	opening	opening	NN
cord-006229-7yoilsho	771	49	.	.	.
cord-006229-7yoilsho	772	1	Fig	fig	NN
cord-006229-7yoilsho	772	2	.	.	.
cord-006229-7yoilsho	772	3	1	1	CD
cord-006229-7yoilsho	773	1	In	in	IN
cord-006229-7yoilsho	773	2	a	a	DT
cord-006229-7yoilsho	773	3	similarity	similarity	NN
cord-006229-7yoilsho	773	4	search	search	NN
cord-006229-7yoilsho	773	5	using	use	VBG
cord-006229-7yoilsho	773	6	sequence	sequence	NN
cord-006229-7yoilsho	773	7	motifs	motif	NNS
cord-006229-7yoilsho	773	8	conserved	conserve	VBN
cord-006229-7yoilsho	773	9	amongst	amongst	IN
cord-006229-7yoilsho	773	10	various	various	JJ
cord-006229-7yoilsho	773	11	members	member	NNS
cord-006229-7yoilsho	773	12	of	of	IN
cord-006229-7yoilsho	773	13	the	the	DT
cord-006229-7yoilsho	773	14	TRP	TRP	NNP
cord-006229-7yoilsho	773	15	protein	protein	NN
cord-006229-7yoilsho	773	16	family	family	NN
cord-006229-7yoilsho	773	17	we	-PRON-	PRP
cord-006229-7yoilsho	773	18	identified	identify	VBD
cord-006229-7yoilsho	773	19	three	three	CD
cord-006229-7yoilsho	773	20	non	non	JJ
cord-006229-7yoilsho	773	21	-	-	JJ
cord-006229-7yoilsho	773	22	annotated	annotated	JJ
cord-006229-7yoilsho	773	23	putative	putative	JJ
cord-006229-7yoilsho	773	24	membrane	membrane	NN
cord-006229-7yoilsho	773	25	proteins	protein	NNS
cord-006229-7yoilsho	773	26	that	that	IN
cord-006229-7yoilsho	773	27	we	-PRON-	PRP
cord-006229-7yoilsho	773	28	initially	initially	RB
cord-006229-7yoilsho	773	29	termed	term	VBD
cord-006229-7yoilsho	773	30	TMEM1	tmem1	XX
cord-006229-7yoilsho	773	31	,	,	,
cord-006229-7yoilsho	774	1	TMEM2	TMEM2	NNPS
cord-006229-7yoilsho	774	2	and	and	CC
cord-006229-7yoilsho	774	3	TMEM4	tmem4	NN
cord-006229-7yoilsho	774	4	.	.	.
cord-006229-7yoilsho	775	1	Expression	expression	NN
cord-006229-7yoilsho	775	2	analysis	analysis	NN
cord-006229-7yoilsho	775	3	using	use	VBG
cord-006229-7yoilsho	775	4	the	the	DT
cord-006229-7yoilsho	775	5	NanoString	NanoString	NNP
cord-006229-7yoilsho	775	6	nCounter	nCounter	NNP
cord-006229-7yoilsho	775	7	system	system	NN
cord-006229-7yoilsho	775	8	,	,	,
cord-006229-7yoilsho	775	9	Northern	Northern	NNP
cord-006229-7yoilsho	775	10	Blotting	Blotting	NNP
cord-006229-7yoilsho	775	11	and	and	CC
cord-006229-7yoilsho	775	12	RT	RT	NNP
cord-006229-7yoilsho	775	13	-	-	HYPH
cord-006229-7yoilsho	775	14	PCR	PCR	NNP
cord-006229-7yoilsho	775	15	showed	show	VBD
cord-006229-7yoilsho	775	16	that	that	IN
cord-006229-7yoilsho	775	17	murine	murine	JJ
cord-006229-7yoilsho	775	18	TMEM2	TMEM2	NNS
cord-006229-7yoilsho	775	19	is	be	VBZ
cord-006229-7yoilsho	775	20	expressed	express	VBN
cord-006229-7yoilsho	775	21	in	in	IN
cord-006229-7yoilsho	775	22	various	various	JJ
cord-006229-7yoilsho	775	23	tissues	tissue	NNS
cord-006229-7yoilsho	775	24	including	include	VBG
cord-006229-7yoilsho	775	25	heart	heart	NN
cord-006229-7yoilsho	775	26	,	,	,
cord-006229-7yoilsho	775	27	brain	brain	NN
cord-006229-7yoilsho	775	28	,	,	,
cord-006229-7yoilsho	775	29	lung	lung	NN
cord-006229-7yoilsho	775	30	,	,	,
cord-006229-7yoilsho	775	31	endothelium	endothelium	NN
cord-006229-7yoilsho	775	32	,	,	,
cord-006229-7yoilsho	775	33	colon	colon	NN
cord-006229-7yoilsho	775	34	,	,	,
cord-006229-7yoilsho	775	35	cardiac	cardiac	NN
cord-006229-7yoilsho	775	36	myocytes	myocyte	NNS
cord-006229-7yoilsho	775	37	,	,	,
cord-006229-7yoilsho	775	38	cardiac	cardiac	JJ
cord-006229-7yoilsho	775	39	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	775	40	,	,	,
cord-006229-7yoilsho	775	41	embryonic	embryonic	JJ
cord-006229-7yoilsho	775	42	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	775	43	,	,	,
cord-006229-7yoilsho	775	44	mast	mast	NN
cord-006229-7yoilsho	775	45	cells	cell	NNS
cord-006229-7yoilsho	775	46	and	and	CC
cord-006229-7yoilsho	775	47	pancreatic	pancreatic	JJ
cord-006229-7yoilsho	775	48	acinar	acinar	NN
cord-006229-7yoilsho	775	49	cells	cell	NNS
cord-006229-7yoilsho	775	50	.	.	.
cord-006229-7yoilsho	776	1	Hydropathy	Hydropathy	NNP
cord-006229-7yoilsho	776	2	analysis	analysis	NN
cord-006229-7yoilsho	776	3	predicts	predict	VBZ
cord-006229-7yoilsho	776	4	that	that	IN
cord-006229-7yoilsho	776	5	TMEM2	TMEM2	NNS
cord-006229-7yoilsho	776	6	proteins	protein	NNS
cord-006229-7yoilsho	776	7	exhibit	exhibit	VBP
cord-006229-7yoilsho	776	8	6	6	CD
cord-006229-7yoilsho	776	9	to	to	TO
cord-006229-7yoilsho	776	10	10	10	CD
cord-006229-7yoilsho	776	11	plasma	plasma	NN
cord-006229-7yoilsho	776	12	-	-	HYPH
cord-006229-7yoilsho	776	13	membrane	membrane	NN
cord-006229-7yoilsho	776	14	spanning	spanning	NN
cord-006229-7yoilsho	776	15	domains	domain	NNS
cord-006229-7yoilsho	776	16	,	,	,
cord-006229-7yoilsho	776	17	but	but	CC
cord-006229-7yoilsho	776	18	fluorescently	fluorescently	RB
cord-006229-7yoilsho	776	19	labeled	label	VBN
cord-006229-7yoilsho	776	20	TMEM2	tmem2	NN
cord-006229-7yoilsho	776	21	fusion	fusion	NN
cord-006229-7yoilsho	776	22	constructs	construct	NNS
cord-006229-7yoilsho	776	23	expressed	express	VBN
cord-006229-7yoilsho	776	24	in	in	IN
cord-006229-7yoilsho	776	25	mouse	mouse	NN
cord-006229-7yoilsho	776	26	embryonic	embryonic	JJ
cord-006229-7yoilsho	776	27	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	776	28	revealed	reveal	VBD
cord-006229-7yoilsho	776	29	a	a	DT
cord-006229-7yoilsho	776	30	vesicular	vesicular	JJ
cord-006229-7yoilsho	776	31	subcellular	subcellular	JJ
cord-006229-7yoilsho	776	32	localization	localization	NN
cord-006229-7yoilsho	776	33	pattern	pattern	NN
cord-006229-7yoilsho	776	34	.	.	.
cord-006229-7yoilsho	777	1	In	in	IN
cord-006229-7yoilsho	777	2	contrast	contrast	NN
cord-006229-7yoilsho	777	3	to	to	IN
cord-006229-7yoilsho	777	4	the	the	DT
cord-006229-7yoilsho	777	5	prediction	prediction	NN
cord-006229-7yoilsho	777	6	by	by	IN
cord-006229-7yoilsho	777	7	the	the	DT
cord-006229-7yoilsho	777	8	PSORT	PSORT	NNP
cord-006229-7yoilsho	777	9	II	II	NNP
cord-006229-7yoilsho	777	10	algorithm	algorithm	NN
cord-006229-7yoilsho	777	11	,	,	,
cord-006229-7yoilsho	777	12	TMEM2-eYFP	TMEM2-eYFP	NNP
cord-006229-7yoilsho	777	13	could	could	MD
cord-006229-7yoilsho	777	14	not	not	RB
cord-006229-7yoilsho	777	15	be	be	VB
cord-006229-7yoilsho	777	16	identified	identify	VBN
cord-006229-7yoilsho	777	17	in	in	IN
cord-006229-7yoilsho	777	18	the	the	DT
cord-006229-7yoilsho	777	19	plasma	plasma	NN
cord-006229-7yoilsho	777	20	membrane	membrane	NN
cord-006229-7yoilsho	777	21	of	of	IN
cord-006229-7yoilsho	777	22	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	777	23	,	,	,
cord-006229-7yoilsho	777	24	cardiac	cardiac	NN
cord-006229-7yoilsho	777	25	myocytes	myocyte	NNS
cord-006229-7yoilsho	777	26	,	,	,
cord-006229-7yoilsho	777	27	mast	mast	NN
cord-006229-7yoilsho	777	28	cells	cell	NNS
cord-006229-7yoilsho	777	29	or	or	CC
cord-006229-7yoilsho	777	30	pancreatic	pancreatic	JJ
cord-006229-7yoilsho	777	31	acinar	acinar	NN
cord-006229-7yoilsho	777	32	cells	cell	NNS
cord-006229-7yoilsho	777	33	but	but	CC
cord-006229-7yoilsho	777	34	showed	show	VBD
cord-006229-7yoilsho	777	35	a	a	DT
cord-006229-7yoilsho	777	36	significant	significant	JJ
cord-006229-7yoilsho	777	37	colocalization	colocalization	NN
cord-006229-7yoilsho	777	38	with	with	IN
cord-006229-7yoilsho	777	39	markers	marker	NNS
cord-006229-7yoilsho	777	40	and	and	CC
cord-006229-7yoilsho	777	41	fusion	fusion	NN
cord-006229-7yoilsho	777	42	constructs	construct	NNS
cord-006229-7yoilsho	777	43	specific	specific	JJ
cord-006229-7yoilsho	777	44	for	for	IN
cord-006229-7yoilsho	777	45	acidic	acidic	JJ
cord-006229-7yoilsho	777	46	compartments	compartment	NNS
cord-006229-7yoilsho	777	47	including	include	VBG
cord-006229-7yoilsho	777	48	lysosomes	lysosome	NNS
cord-006229-7yoilsho	777	49	.	.	.
cord-006229-7yoilsho	778	1	In	in	IN
cord-006229-7yoilsho	778	2	TMEM2	TMEM2	NNP
cord-006229-7yoilsho	778	3	-/mice	-/mice	NNP
cord-006229-7yoilsho	778	4	,	,	,
cord-006229-7yoilsho	778	5	a	a	DT
cord-006229-7yoilsho	778	6	marked	mark	VBN
cord-006229-7yoilsho	778	7	elevation	elevation	NN
cord-006229-7yoilsho	778	8	of	of	IN
cord-006229-7yoilsho	778	9	amylase	amylase	NN
cord-006229-7yoilsho	778	10	and	and	CC
cord-006229-7yoilsho	778	11	lipase	lipase	NN
cord-006229-7yoilsho	778	12	plasma	plasma	NN
cord-006229-7yoilsho	778	13	levels	level	NNS
cord-006229-7yoilsho	778	14	was	be	VBD
cord-006229-7yoilsho	778	15	observed	observe	VBN
cord-006229-7yoilsho	778	16	.	.	.
cord-006229-7yoilsho	779	1	We	-PRON-	PRP
cord-006229-7yoilsho	779	2	found	find	VBD
cord-006229-7yoilsho	779	3	that	that	IN
cord-006229-7yoilsho	779	4	constitutive	constitutive	JJ
cord-006229-7yoilsho	779	5	but	but	CC
cord-006229-7yoilsho	779	6	not	not	RB
cord-006229-7yoilsho	779	7	stimulated	stimulate	VBN
cord-006229-7yoilsho	779	8	amylase	amylase	NN
cord-006229-7yoilsho	779	9	secretion	secretion	NN
cord-006229-7yoilsho	779	10	from	from	IN
cord-006229-7yoilsho	779	11	TMEM2-deficient	TMEM2-deficient	NNP
cord-006229-7yoilsho	779	12	acinar	acinar	JJ
cord-006229-7yoilsho	779	13	cells	cell	NNS
cord-006229-7yoilsho	779	14	is	be	VBZ
cord-006229-7yoilsho	779	15	elevated	elevate	VBN
cord-006229-7yoilsho	779	16	indicating	indicate	VBG
cord-006229-7yoilsho	779	17	a	a	DT
cord-006229-7yoilsho	779	18	cell	cell	NN
cord-006229-7yoilsho	779	19	autonomous	autonomous	JJ
cord-006229-7yoilsho	779	20	defect	defect	NN
cord-006229-7yoilsho	779	21	.	.	.
cord-006229-7yoilsho	780	1	Calcium	calcium	NN
cord-006229-7yoilsho	781	1	(	(	-LRB-
cord-006229-7yoilsho	781	2	Ca	ca	NN
cord-006229-7yoilsho	781	3	+	+	CC
cord-006229-7yoilsho	781	4	+	+	CC
cord-006229-7yoilsho	781	5	)	)	-RRB-
cord-006229-7yoilsho	781	6	is	be	VBZ
cord-006229-7yoilsho	781	7	an	an	DT
cord-006229-7yoilsho	781	8	important	important	JJ
cord-006229-7yoilsho	781	9	signaling	signaling	NN
cord-006229-7yoilsho	781	10	molecule	molecule	NN
cord-006229-7yoilsho	781	11	regulating	regulating	NN
cord-006229-7yoilsho	781	12	stimulated	stimulate	VBN
cord-006229-7yoilsho	781	13	as	as	RB
cord-006229-7yoilsho	781	14	well	well	RB
cord-006229-7yoilsho	781	15	as	as	IN
cord-006229-7yoilsho	781	16	constitutive	constitutive	JJ
cord-006229-7yoilsho	781	17	secretion	secretion	NN
cord-006229-7yoilsho	781	18	from	from	IN
cord-006229-7yoilsho	781	19	pancreatic	pancreatic	JJ
cord-006229-7yoilsho	781	20	acinar	acinar	NN
cord-006229-7yoilsho	781	21	cells	cell	NNS
cord-006229-7yoilsho	781	22	.	.	.
cord-006229-7yoilsho	782	1	Microfluorimetric	microfluorimetric	JJ
cord-006229-7yoilsho	782	2	measurements	measurement	NNS
cord-006229-7yoilsho	782	3	using	use	VBG
cord-006229-7yoilsho	782	4	Fura-2	Fura-2	NNP
cord-006229-7yoilsho	782	5	or	or	CC
cord-006229-7yoilsho	782	6	Indo-1	Indo-1	NNP
cord-006229-7yoilsho	782	7	indicate	indicate	VBP
cord-006229-7yoilsho	782	8	higher	high	JJR
cord-006229-7yoilsho	782	9	resting	resting	NN
cord-006229-7yoilsho	783	1	Ca	Ca	NNP
cord-006229-7yoilsho	783	2	+	+	CC
cord-006229-7yoilsho	784	1	+	+	CC
cord-006229-7yoilsho	784	2	concentrations	concentration	NNS
cord-006229-7yoilsho	784	3	in	in	IN
cord-006229-7yoilsho	784	4	TMEM2-/-pancreatic	tmem2-/-pancreatic	JJ
cord-006229-7yoilsho	784	5	acinar	acinar	NN
cord-006229-7yoilsho	784	6	cells	cell	NNS
cord-006229-7yoilsho	784	7	correlating	correlate	VBG
cord-006229-7yoilsho	784	8	with	with	IN
cord-006229-7yoilsho	784	9	elevated	elevated	JJ
cord-006229-7yoilsho	784	10	basal	basal	NN
cord-006229-7yoilsho	784	11	enzyme	enzyme	NN
cord-006229-7yoilsho	784	12	secretion	secretion	NN
cord-006229-7yoilsho	784	13	.	.	.
cord-006229-7yoilsho	785	1	In	in	IN
cord-006229-7yoilsho	785	2	TMEM2-YFP	tmem2-yfp	NN
cord-006229-7yoilsho	785	3	-	-	HYPH
cord-006229-7yoilsho	785	4	knock	knock	NN
cord-006229-7yoilsho	785	5	-	-	HYPH
cord-006229-7yoilsho	785	6	add	add	VB
cord-006229-7yoilsho	785	7	-	-	HYPH
cord-006229-7yoilsho	785	8	on	on	RP
cord-006229-7yoilsho	785	9	mice	mouse	NNS
cord-006229-7yoilsho	785	10	we	-PRON-	PRP
cord-006229-7yoilsho	785	11	identified	identify	VBD
cord-006229-7yoilsho	785	12	TMEM2	TMEM2	NNS
cord-006229-7yoilsho	785	13	in	in	IN
cord-006229-7yoilsho	785	14	organelles	organelle	NNS
cord-006229-7yoilsho	785	15	of	of	IN
cord-006229-7yoilsho	785	16	the	the	DT
cord-006229-7yoilsho	785	17	apical	apical	JJ
cord-006229-7yoilsho	785	18	acinar	acinar	JJ
cord-006229-7yoilsho	785	19	cell	cell	NN
cord-006229-7yoilsho	785	20	pole	pole	NN
cord-006229-7yoilsho	785	21	and	and	CC
cord-006229-7yoilsho	785	22	a	a	DT
cord-006229-7yoilsho	785	23	partial	partial	JJ
cord-006229-7yoilsho	785	24	colocalisation	colocalisation	NN
cord-006229-7yoilsho	785	25	with	with	IN
cord-006229-7yoilsho	785	26	Lamp2	Lamp2	NNP
cord-006229-7yoilsho	785	27	proteins	protein	NNS
cord-006229-7yoilsho	785	28	.	.	.
cord-006229-7yoilsho	786	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	786	2	,	,	,
cord-006229-7yoilsho	786	3	largely	largely	RB
cord-006229-7yoilsho	786	4	increased	increase	VBN
cord-006229-7yoilsho	786	5	elevations	elevation	NNS
cord-006229-7yoilsho	786	6	in	in	IN
cord-006229-7yoilsho	786	7	cytoplasmic	cytoplasmic	JJ
cord-006229-7yoilsho	786	8	Ca	Ca	NNP
cord-006229-7yoilsho	786	9	+	+	CC
cord-006229-7yoilsho	786	10	+	+	CC
cord-006229-7yoilsho	786	11	concentration	concentration	NN
cord-006229-7yoilsho	786	12	were	be	VBD
cord-006229-7yoilsho	786	13	observed	observe	VBN
cord-006229-7yoilsho	786	14	upon	upon	IN
cord-006229-7yoilsho	786	15	osmotic	osmotic	JJ
cord-006229-7yoilsho	786	16	lysis	lysis	NN
cord-006229-7yoilsho	786	17	of	of	IN
cord-006229-7yoilsho	786	18	lysosomes	lysosome	NNS
cord-006229-7yoilsho	786	19	triggered	trigger	VBN
cord-006229-7yoilsho	786	20	by	by	IN
cord-006229-7yoilsho	786	21	Gly	Gly	NNP
cord-006229-7yoilsho	786	22	-	-	HYPH
cord-006229-7yoilsho	786	23	Phe	Phe	NNP
cord-006229-7yoilsho	786	24	β	β	NNP
cord-006229-7yoilsho	786	25	-	-	HYPH
cord-006229-7yoilsho	786	26	naphthylamide	naphthylamide	NNP
cord-006229-7yoilsho	786	27	(	(	-LRB-
cord-006229-7yoilsho	786	28	GPN	GPN	NNP
cord-006229-7yoilsho	786	29	)	)	-RRB-
cord-006229-7yoilsho	786	30	or	or	CC
cord-006229-7yoilsho	786	31	by	by	IN
cord-006229-7yoilsho	786	32	NH	NH	NNP
cord-006229-7yoilsho	786	33	4	4	CD
cord-006229-7yoilsho	786	34	Cl	Cl	NNP
cord-006229-7yoilsho	786	35	application	application	NN
cord-006229-7yoilsho	786	36	.	.	.
cord-006229-7yoilsho	787	1	The	the	DT
cord-006229-7yoilsho	787	2	role	role	NN
cord-006229-7yoilsho	787	3	of	of	IN
cord-006229-7yoilsho	787	4	TMEM2	TMEM2	NNPS
cord-006229-7yoilsho	787	5	for	for	IN
cord-006229-7yoilsho	787	6	Ca	Ca	NNP
cord-006229-7yoilsho	788	1	+	+	CC
cord-006229-7yoilsho	788	2	+	+	CC
cord-006229-7yoilsho	788	3	release	release	NN
cord-006229-7yoilsho	788	4	was	be	VBD
cord-006229-7yoilsho	788	5	evaluated	evaluate	VBN
cord-006229-7yoilsho	788	6	by	by	IN
cord-006229-7yoilsho	788	7	stimulation	stimulation	NN
cord-006229-7yoilsho	788	8	with	with	IN
cord-006229-7yoilsho	788	9	low	low	JJ
cord-006229-7yoilsho	788	10	concentration	concentration	NN
cord-006229-7yoilsho	788	11	of	of	IN
cord-006229-7yoilsho	788	12	cholecystokinin	cholecystokinin	NN
cord-006229-7yoilsho	788	13	2pM	2pm	CD
cord-006229-7yoilsho	788	14	)	)	-RRB-
cord-006229-7yoilsho	788	15	in	in	IN
cord-006229-7yoilsho	788	16	the	the	DT
cord-006229-7yoilsho	788	17	absence	absence	NN
cord-006229-7yoilsho	788	18	of	of	IN
cord-006229-7yoilsho	788	19	extracellular	extracellular	JJ
cord-006229-7yoilsho	788	20	Ca	Ca	NNP
cord-006229-7yoilsho	788	21	+	+	CC
cord-006229-7yoilsho	789	1	+	+	CC
cord-006229-7yoilsho	789	2	using	use	VBG
cord-006229-7yoilsho	789	3	both	both	CC
cord-006229-7yoilsho	789	4	microfluorimetric	microfluorimetric	JJ
cord-006229-7yoilsho	789	5	recording	recording	NN
cord-006229-7yoilsho	789	6	of	of	IN
cord-006229-7yoilsho	790	1	cytosolic	cytosolic	JJ
cord-006229-7yoilsho	790	2	Ca	Ca	NNP
cord-006229-7yoilsho	790	3	+	+	CC
cord-006229-7yoilsho	790	4	+	+	CC
cord-006229-7yoilsho	790	5	transients	transient	NNS
cord-006229-7yoilsho	790	6	as	as	RB
cord-006229-7yoilsho	790	7	well	well	RB
cord-006229-7yoilsho	790	8	as	as	IN
cord-006229-7yoilsho	790	9	electrophysiological	electrophysiological	JJ
cord-006229-7yoilsho	790	10	recordings	recording	NNS
cord-006229-7yoilsho	790	11	of	of	IN
cord-006229-7yoilsho	790	12	Ca	Ca	NNP
cord-006229-7yoilsho	790	13	+	+	CC
cord-006229-7yoilsho	790	14	+	+	CC
cord-006229-7yoilsho	790	15	-activated	-activated	JJ
cord-006229-7yoilsho	790	16	chloride	chloride	NN
cord-006229-7yoilsho	790	17	currents	current	NNS
cord-006229-7yoilsho	790	18	.	.	.
cord-006229-7yoilsho	791	1	These	these	DT
cord-006229-7yoilsho	791	2	measurements	measurement	NNS
cord-006229-7yoilsho	791	3	revealed	reveal	VBD
cord-006229-7yoilsho	791	4	a	a	DT
cord-006229-7yoilsho	791	5	higher	high	JJR
cord-006229-7yoilsho	791	6	frequency	frequency	NN
cord-006229-7yoilsho	791	7	of	of	IN
cord-006229-7yoilsho	792	1	intracellular	intracellular	JJ
cord-006229-7yoilsho	792	2	Ca	Ca	NNP
cord-006229-7yoilsho	792	3	+	+	CC
cord-006229-7yoilsho	793	1	+	+	CC
cord-006229-7yoilsho	793	2	oscillations	oscillation	NNS
cord-006229-7yoilsho	793	3	and	and	CC
cord-006229-7yoilsho	793	4	a	a	DT
cord-006229-7yoilsho	793	5	larger	large	JJR
cord-006229-7yoilsho	793	6	area	area	NN
cord-006229-7yoilsho	793	7	under	under	IN
cord-006229-7yoilsho	793	8	the	the	DT
cord-006229-7yoilsho	793	9	curve	curve	NN
cord-006229-7yoilsho	793	10	of	of	IN
cord-006229-7yoilsho	793	11	Ca	Ca	NNP
cord-006229-7yoilsho	793	12	+	+	CC
cord-006229-7yoilsho	793	13	+	+	CC
cord-006229-7yoilsho	793	14	activated	activate	VBN
cord-006229-7yoilsho	793	15	chloride	chloride	NN
cord-006229-7yoilsho	793	16	currents	current	NNS
cord-006229-7yoilsho	793	17	upon	upon	IN
cord-006229-7yoilsho	793	18	CCK-8	CCK-8	NNP
cord-006229-7yoilsho	793	19	stimulation	stimulation	NN
cord-006229-7yoilsho	793	20	indicating	indicate	VBG
cord-006229-7yoilsho	793	21	that	that	IN
cord-006229-7yoilsho	793	22	TMEM2	TMEM2	NNS
cord-006229-7yoilsho	793	23	inactivation	inactivation	NN
cord-006229-7yoilsho	793	24	leads	lead	VBZ
cord-006229-7yoilsho	793	25	to	to	IN
cord-006229-7yoilsho	793	26	an	an	DT
cord-006229-7yoilsho	793	27	enhancement	enhancement	NN
cord-006229-7yoilsho	793	28	of	of	IN
cord-006229-7yoilsho	793	29	the	the	DT
cord-006229-7yoilsho	793	30	globalization	globalization	NN
cord-006229-7yoilsho	793	31	of	of	IN
cord-006229-7yoilsho	793	32	CCK-8	CCK-8	NNP
cord-006229-7yoilsho	793	33	evoked	evoke	VBD
cord-006229-7yoilsho	793	34	Ca2	ca2	CD
cord-006229-7yoilsho	793	35	+	+	SYM
cord-006229-7yoilsho	793	36	release	release	NN
cord-006229-7yoilsho	793	37	from	from	IN
cord-006229-7yoilsho	793	38	intracellular	intracellular	JJ
cord-006229-7yoilsho	793	39	organelles	organelle	NNS
cord-006229-7yoilsho	793	40	.	.	.
cord-006229-7yoilsho	794	1	Taken	take	VBN
cord-006229-7yoilsho	794	2	together	together	RB
cord-006229-7yoilsho	794	3	,	,	,
cord-006229-7yoilsho	794	4	our	-PRON-	PRP$
cord-006229-7yoilsho	794	5	study	study	NN
cord-006229-7yoilsho	794	6	identifies	identify	VBZ
cord-006229-7yoilsho	794	7	TMEM2	TMEM2	NNS
cord-006229-7yoilsho	794	8	as	as	IN
cord-006229-7yoilsho	794	9	a	a	DT
cord-006229-7yoilsho	794	10	novel	novel	JJ
cord-006229-7yoilsho	794	11	regulator	regulator	NN
cord-006229-7yoilsho	794	12	of	of	IN
cord-006229-7yoilsho	794	13	Ca	Ca	NNP
cord-006229-7yoilsho	794	14	+	+	CC
cord-006229-7yoilsho	795	1	+	+	CC
cord-006229-7yoilsho	795	2	release	release	NN
cord-006229-7yoilsho	795	3	from	from	IN
cord-006229-7yoilsho	795	4	intracellular	intracellular	JJ
cord-006229-7yoilsho	795	5	organelles	organelle	NNS
cord-006229-7yoilsho	795	6	including	include	VBG
cord-006229-7yoilsho	795	7	endo	endo	NN
cord-006229-7yoilsho	795	8	-	-	HYPH
cord-006229-7yoilsho	795	9	lysosomes	lysosome	NNS
cord-006229-7yoilsho	795	10	and	and	CC
cord-006229-7yoilsho	795	11	as	as	IN
cord-006229-7yoilsho	795	12	a	a	DT
cord-006229-7yoilsho	795	13	critical	critical	JJ
cord-006229-7yoilsho	795	14	determinant	determinant	NN
cord-006229-7yoilsho	795	15	of	of	IN
cord-006229-7yoilsho	795	16	constitutive	constitutive	JJ
cord-006229-7yoilsho	795	17	protein	protein	NN
cord-006229-7yoilsho	795	18	secretion	secretion	NN
cord-006229-7yoilsho	795	19	in	in	IN
cord-006229-7yoilsho	795	20	pancreatic	pancreatic	JJ
cord-006229-7yoilsho	795	21	acinar	acinar	NN
cord-006229-7yoilsho	795	22	cells	cell	NNS
cord-006229-7yoilsho	795	23	.	.	.
cord-006229-7yoilsho	796	1	While	while	IN
cord-006229-7yoilsho	796	2	generally	generally	RB
cord-006229-7yoilsho	796	3	highlighting	highlight	VBG
cord-006229-7yoilsho	796	4	toxicology	toxicology	NN
cord-006229-7yoilsho	796	5	as	as	IN
cord-006229-7yoilsho	796	6	a	a	DT
cord-006229-7yoilsho	796	7	translational	translational	JJ
cord-006229-7yoilsho	796	8	science	science	NN
cord-006229-7yoilsho	796	9	that	that	WDT
cord-006229-7yoilsho	796	10	requires	require	VBZ
cord-006229-7yoilsho	796	11	academic	academic	JJ
cord-006229-7yoilsho	796	12	anchoring	anchoring	NN
cord-006229-7yoilsho	796	13	,	,	,
cord-006229-7yoilsho	796	14	Gundert	Gundert	NNP
cord-006229-7yoilsho	796	15	-	-	HYPH
cord-006229-7yoilsho	796	16	Remy	Remy	NNP
cord-006229-7yoilsho	796	17	and	and	CC
cord-006229-7yoilsho	796	18	co	co	NNS
cord-006229-7yoilsho	796	19	-	-	NNS
cord-006229-7yoilsho	796	20	workers	worker	NNS
cord-006229-7yoilsho	796	21	[	[	-LRB-
cord-006229-7yoilsho	796	22	1	1	CD
cord-006229-7yoilsho	796	23	]	]	-RRB-
cord-006229-7yoilsho	796	24	have	have	VBP
cord-006229-7yoilsho	796	25	called	call	VBN
cord-006229-7yoilsho	796	26	for	for	IN
cord-006229-7yoilsho	796	27	efforts	effort	NNS
cord-006229-7yoilsho	796	28	to	to	TO
cord-006229-7yoilsho	796	29	improve	improve	VB
cord-006229-7yoilsho	796	30	the	the	DT
cord-006229-7yoilsho	796	31	relevance	relevance	NN
cord-006229-7yoilsho	796	32	of	of	IN
cord-006229-7yoilsho	796	33	in	in	FW
cord-006229-7yoilsho	796	34	vitro	vitro	FW
cord-006229-7yoilsho	796	35	methodologies	methodology	NNS
cord-006229-7yoilsho	796	36	in	in	IN
cord-006229-7yoilsho	796	37	predicting	predict	VBG
cord-006229-7yoilsho	796	38	in	in	IN
cord-006229-7yoilsho	796	39	vivo	vivo	NN
cord-006229-7yoilsho	796	40	effects	effect	NNS
cord-006229-7yoilsho	796	41	.	.	.
cord-006229-7yoilsho	797	1	Against	against	IN
cord-006229-7yoilsho	797	2	this	this	DT
cord-006229-7yoilsho	797	3	background	background	NN
cord-006229-7yoilsho	797	4	,	,	,
cord-006229-7yoilsho	797	5	the	the	DT
cord-006229-7yoilsho	797	6	German	German	NNP
cord-006229-7yoilsho	797	7	Society	Society	NNP
cord-006229-7yoilsho	797	8	of	of	IN
cord-006229-7yoilsho	797	9	Toxicology	Toxicology	NNP
cord-006229-7yoilsho	797	10	Working	Working	NNP
cord-006229-7yoilsho	797	11	Group	Group	NNP
cord-006229-7yoilsho	797	12	on	on	IN
cord-006229-7yoilsho	797	13	Alternative	Alternative	NNP
cord-006229-7yoilsho	797	14	Approaches	Approaches	NNPS
cord-006229-7yoilsho	797	15	to	to	IN
cord-006229-7yoilsho	797	16	Animal	Animal	NNP
cord-006229-7yoilsho	797	17	Testing	Testing	NNP
cord-006229-7yoilsho	797	18	proposes	propose	VBZ
cord-006229-7yoilsho	797	19	specific	specific	JJ
cord-006229-7yoilsho	797	20	quality	quality	NN
cord-006229-7yoilsho	797	21	criteria	criterion	NNS
cord-006229-7yoilsho	797	22	(	(	-LRB-
cord-006229-7yoilsho	797	23	QC	QC	NNP
cord-006229-7yoilsho	797	24	)	)	-RRB-
cord-006229-7yoilsho	797	25	for	for	IN
cord-006229-7yoilsho	797	26	in	in	FW
cord-006229-7yoilsho	797	27	vitro	vitro	FW
cord-006229-7yoilsho	797	28	methods	method	NNS
cord-006229-7yoilsho	797	29	and	and	CC
cord-006229-7yoilsho	797	30	for	for	IN
cord-006229-7yoilsho	797	31	research	research	NN
cord-006229-7yoilsho	797	32	work	work	NN
cord-006229-7yoilsho	797	33	using	use	VBG
cord-006229-7yoilsho	797	34	in	in	IN
cord-006229-7yoilsho	797	35	vitro	vitro	FW
cord-006229-7yoilsho	797	36	methods	method	NNS
cord-006229-7yoilsho	797	37	.	.	.
cord-006229-7yoilsho	798	1	These	these	DT
cord-006229-7yoilsho	798	2	QC	QC	NNP
cord-006229-7yoilsho	798	3	may	may	MD
cord-006229-7yoilsho	798	4	serve	serve	VB
cord-006229-7yoilsho	798	5	to	to	TO
cord-006229-7yoilsho	798	6	evaluate	evaluate	VB
cord-006229-7yoilsho	798	7	in	in	IN
cord-006229-7yoilsho	798	8	vitro	vitro	FW
cord-006229-7yoilsho	798	9	methods	method	NNS
cord-006229-7yoilsho	798	10	that	that	WDT
cord-006229-7yoilsho	798	11	are	be	VBP
cord-006229-7yoilsho	798	12	developed	develop	VBN
cord-006229-7yoilsho	798	13	or	or	CC
cord-006229-7yoilsho	798	14	applied	apply	VBN
cord-006229-7yoilsho	798	15	in	in	IN
cord-006229-7yoilsho	798	16	-	-	HYPH
cord-006229-7yoilsho	798	17	house	house	NN
cord-006229-7yoilsho	798	18	or	or	CC
cord-006229-7yoilsho	798	19	that	that	WDT
cord-006229-7yoilsho	798	20	are	be	VBP
cord-006229-7yoilsho	798	21	described	describe	VBN
cord-006229-7yoilsho	798	22	in	in	IN
cord-006229-7yoilsho	798	23	work	work	NN
cord-006229-7yoilsho	798	24	plans	plan	NNS
cord-006229-7yoilsho	798	25	,	,	,
cord-006229-7yoilsho	798	26	peer	peer	NN
cord-006229-7yoilsho	798	27	reviewed	review	VBN
cord-006229-7yoilsho	798	28	articles	article	NNS
cord-006229-7yoilsho	798	29	,	,	,
cord-006229-7yoilsho	798	30	etc	etc	FW
cord-006229-7yoilsho	798	31	.	.	.
cord-006229-7yoilsho	799	1	For	for	IN
cord-006229-7yoilsho	799	2	the	the	DT
cord-006229-7yoilsho	799	3	time	time	NN
cord-006229-7yoilsho	799	4	being	be	VBG
cord-006229-7yoilsho	799	5	,	,	,
cord-006229-7yoilsho	799	6	the	the	DT
cord-006229-7yoilsho	799	7	QC	QC	NNP
cord-006229-7yoilsho	799	8	focus	focus	NN
cord-006229-7yoilsho	799	9	on	on	IN
cord-006229-7yoilsho	799	10	in	in	IN
cord-006229-7yoilsho	799	11	vitro	vitro	FW
cord-006229-7yoilsho	799	12	cell	cell	NN
cord-006229-7yoilsho	799	13	or	or	CC
cord-006229-7yoilsho	799	14	tissue	tissue	NN
cord-006229-7yoilsho	799	15	culture	culture	NN
cord-006229-7yoilsho	799	16	methods	method	NNS
cord-006229-7yoilsho	799	17	that	that	WDT
cord-006229-7yoilsho	799	18	address	address	VBP
cord-006229-7yoilsho	799	19	human	human	JJ
cord-006229-7yoilsho	799	20	health	health	NN
cord-006229-7yoilsho	799	21	endpoints	endpoint	NNS
cord-006229-7yoilsho	799	22	in	in	IN
cord-006229-7yoilsho	799	23	the	the	DT
cord-006229-7yoilsho	799	24	context	context	NN
cord-006229-7yoilsho	799	25	of	of	IN
cord-006229-7yoilsho	799	26	substance	substance	NN
cord-006229-7yoilsho	799	27	-	-	HYPH
cord-006229-7yoilsho	799	28	related	relate	VBN
cord-006229-7yoilsho	799	29	regulatory	regulatory	JJ
cord-006229-7yoilsho	799	30	toxicity	toxicity	NN
cord-006229-7yoilsho	799	31	testing	testing	NN
cord-006229-7yoilsho	799	32	.	.	.
cord-006229-7yoilsho	800	1	Nevertheless	nevertheless	RB
cord-006229-7yoilsho	800	2	,	,	,
cord-006229-7yoilsho	800	3	these	these	DT
cord-006229-7yoilsho	800	4	QC	QC	NNP
cord-006229-7yoilsho	800	5	are	be	VBP
cord-006229-7yoilsho	800	6	also	also	RB
cord-006229-7yoilsho	800	7	generally	generally	RB
cord-006229-7yoilsho	800	8	applicable	applicable	JJ
cord-006229-7yoilsho	800	9	to	to	IN
cord-006229-7yoilsho	800	10	in	in	FW
cord-006229-7yoilsho	800	11	vitro	vitro	FW
cord-006229-7yoilsho	800	12	research	research	NN
cord-006229-7yoilsho	800	13	conducted	conduct	VBN
cord-006229-7yoilsho	800	14	for	for	IN
cord-006229-7yoilsho	800	15	other	other	JJ
cord-006229-7yoilsho	800	16	toxicological	toxicological	JJ
cord-006229-7yoilsho	800	17	purposes	purpose	NNS
cord-006229-7yoilsho	800	18	.	.	.
cord-006229-7yoilsho	801	1	Relevant	relevant	JJ
cord-006229-7yoilsho	801	2	work	work	NN
cord-006229-7yoilsho	801	3	from	from	IN
cord-006229-7yoilsho	801	4	,	,	,
cord-006229-7yoilsho	801	5	e.g.	e.g.	RB
cord-006229-7yoilsho	801	6	,	,	,
cord-006229-7yoilsho	801	7	the	the	DT
cord-006229-7yoilsho	801	8	Organisation	Organisation	NNP
cord-006229-7yoilsho	801	9	for	for	IN
cord-006229-7yoilsho	801	10	the	the	DT
cord-006229-7yoilsho	801	11	Economic	Economic	NNP
cord-006229-7yoilsho	801	12	Co	co	NN
cord-006229-7yoilsho	801	13	-	-	NN
cord-006229-7yoilsho	801	14	operation	operation	NN
cord-006229-7yoilsho	801	15	and	and	CC
cord-006229-7yoilsho	801	16	Development	Development	NNP
cord-006229-7yoilsho	801	17	has	have	VBZ
cord-006229-7yoilsho	801	18	been	be	VBN
cord-006229-7yoilsho	801	19	taken	take	VBN
cord-006229-7yoilsho	801	20	into	into	IN
cord-006229-7yoilsho	801	21	account	account	NN
cord-006229-7yoilsho	801	22	in	in	IN
cord-006229-7yoilsho	801	23	specifying	specify	VBG
cord-006229-7yoilsho	801	24	the	the	DT
cord-006229-7yoilsho	801	25	QC	QC	NNP
cord-006229-7yoilsho	801	26	that	that	WDT
cord-006229-7yoilsho	801	27	cover	cover	VBP
cord-006229-7yoilsho	801	28	the	the	DT
cord-006229-7yoilsho	801	29	following	follow	VBG
cord-006229-7yoilsho	801	30	aspects	aspect	NNS
cord-006229-7yoilsho	801	31	:	:	:
cord-006229-7yoilsho	801	32			.
cord-006229-7yoilsho	802	1	The	the	DT
cord-006229-7yoilsho	802	2	3Rs	3rs	JJ
cord-006229-7yoilsho	802	3	impact	impact	NN
cord-006229-7yoilsho	802	4	of	of	IN
cord-006229-7yoilsho	802	5	an	an	DT
cord-006229-7yoilsho	802	6	in	in	FW
cord-006229-7yoilsho	802	7	vitro	vitro	FW
cord-006229-7yoilsho	802	8	method	method	NN
cord-006229-7yoilsho	802	9	in	in	IN
cord-006229-7yoilsho	802	10	replacing	replace	VBG
cord-006229-7yoilsho	802	11	,	,	,
cord-006229-7yoilsho	802	12	reducing	reduce	VBG
cord-006229-7yoilsho	802	13	(	(	-LRB-
cord-006229-7yoilsho	802	14	and	and	CC
cord-006229-7yoilsho	802	15	refining	refine	VBG
cord-006229-7yoilsho	802	16	)	)	-RRB-
cord-006229-7yoilsho	802	17	a	a	DT
cord-006229-7yoilsho	802	18	specific	specific	JJ
cord-006229-7yoilsho	802	19	animal	animal	NN
cord-006229-7yoilsho	802	20	test	test	NN
cord-006229-7yoilsho	802	21	for	for	IN
cord-006229-7yoilsho	802	22	a	a	DT
cord-006229-7yoilsho	802	23	specific	specific	JJ
cord-006229-7yoilsho	802	24	toxicological	toxicological	JJ
cord-006229-7yoilsho	802	25	endpoint	endpoint	NN
cord-006229-7yoilsho	802	26	.	.	.
cord-006229-7yoilsho	803	1	This	this	DT
cord-006229-7yoilsho	803	2	aspect	aspect	NN
cord-006229-7yoilsho	803	3	also	also	RB
cord-006229-7yoilsho	803	4	includes	include	VBZ
cord-006229-7yoilsho	803	5	scientific	scientific	JJ
cord-006229-7yoilsho	803	6	hurdles	hurdle	NNS
cord-006229-7yoilsho	803	7	that	that	WDT
cord-006229-7yoilsho	803	8	,	,	,
cord-006229-7yoilsho	803	9	in	in	IN
cord-006229-7yoilsho	803	10	the	the	DT
cord-006229-7yoilsho	803	11	past	past	NN
cord-006229-7yoilsho	803	12	,	,	,
cord-006229-7yoilsho	803	13	had	have	VBD
cord-006229-7yoilsho	803	14	impeded	impede	VBN
cord-006229-7yoilsho	803	15	the	the	DT
cord-006229-7yoilsho	803	16	successful	successful	JJ
cord-006229-7yoilsho	803	17	development	development	NN
cord-006229-7yoilsho	803	18	of	of	IN
cord-006229-7yoilsho	803	19	in	in	FW
cord-006229-7yoilsho	803	20	vitro	vitro	FW
cord-006229-7yoilsho	803	21	methods	method	NNS
cord-006229-7yoilsho	803	22	for	for	IN
cord-006229-7yoilsho	803	23	the	the	DT
cord-006229-7yoilsho	803	24	given	give	VBN
cord-006229-7yoilsho	803	25	toxicological	toxicological	JJ
cord-006229-7yoilsho	803	26	endpoint	endpoint	NN
cord-006229-7yoilsho	803	27	.	.	.
cord-006229-7yoilsho	804	1			NFP
cord-006229-7yoilsho	805	1	Scientific	scientific	JJ
cord-006229-7yoilsho	805	2	relevance	relevance	NN
cord-006229-7yoilsho	805	3	and	and	CC
cord-006229-7yoilsho	805	4	reliability	reliability	NN
cord-006229-7yoilsho	805	5	,	,	,
cord-006229-7yoilsho	805	6	i.e.	i.e.	FW
cord-006229-7yoilsho	805	7	which	which	WDT
cord-006229-7yoilsho	805	8	fundamental	fundamental	JJ
cord-006229-7yoilsho	805	9	requirements	requirement	NNS
cord-006229-7yoilsho	805	10	should	should	MD
cord-006229-7yoilsho	805	11	an	an	DT
cord-006229-7yoilsho	805	12	in	in	IN
cord-006229-7yoilsho	805	13	vitro	vitro	FW
cord-006229-7yoilsho	805	14	method	method	NN
cord-006229-7yoilsho	805	15	meet	meet	VBP
cord-006229-7yoilsho	805	16	to	to	TO
cord-006229-7yoilsho	805	17	ensure	ensure	VB
cord-006229-7yoilsho	805	18	that	that	IN
cord-006229-7yoilsho	805	19	its	-PRON-	PRP$
cord-006229-7yoilsho	805	20	results	result	NNS
cord-006229-7yoilsho	805	21	are	be	VBP
cord-006229-7yoilsho	805	22	relevant	relevant	JJ
cord-006229-7yoilsho	805	23	and	and	CC
cord-006229-7yoilsho	805	24	reliable	reliable	JJ
cord-006229-7yoilsho	805	25	.	.	.
cord-006229-7yoilsho	806	1			NFP
cord-006229-7yoilsho	807	1	Practicability	practicability	NN
cord-006229-7yoilsho	807	2	and	and	CC
cord-006229-7yoilsho	807	3	applicability	applicability	NN
cord-006229-7yoilsho	807	4	,	,	,
cord-006229-7yoilsho	807	5	i.e.	i.e.	FW
cord-006229-7yoilsho	807	6	what	what	WP
cord-006229-7yoilsho	807	7	is	be	VBZ
cord-006229-7yoilsho	807	8	the	the	DT
cord-006229-7yoilsho	807	9	expected	expect	VBN
cord-006229-7yoilsho	807	10	expenditure	expenditure	NN
cord-006229-7yoilsho	807	11	for	for	IN
cord-006229-7yoilsho	807	12	the	the	DT
cord-006229-7yoilsho	807	13	in	in	FW
cord-006229-7yoilsho	807	14	vitro	vitro	FW
cord-006229-7yoilsho	807	15	method	method	NN
cord-006229-7yoilsho	807	16	,	,	,
cord-006229-7yoilsho	807	17	and	and	CC
cord-006229-7yoilsho	807	18	have	have	VBP
cord-006229-7yoilsho	807	19	relevant	relevant	JJ
cord-006229-7yoilsho	807	20	authorities	authority	NNS
cord-006229-7yoilsho	807	21	and	and	CC
cord-006229-7yoilsho	807	22	industrial	industrial	JJ
cord-006229-7yoilsho	807	23	sectors	sector	NNS
cord-006229-7yoilsho	807	24	been	be	VBN
cord-006229-7yoilsho	807	25	involved	involve	VBN
cord-006229-7yoilsho	807	26	in	in	IN
cord-006229-7yoilsho	807	27	the	the	DT
cord-006229-7yoilsho	807	28	development	development	NN
cord-006229-7yoilsho	807	29	of	of	IN
cord-006229-7yoilsho	807	30	the	the	DT
cord-006229-7yoilsho	807	31	in	in	FW
cord-006229-7yoilsho	807	32	vitro	vitro	FW
cord-006229-7yoilsho	807	33	method	method	NN
cord-006229-7yoilsho	807	34	.	.	.
cord-006229-7yoilsho	808	1	QC	QC	NNP
cord-006229-7yoilsho	808	2	related	relate	VBN
cord-006229-7yoilsho	808	3	to	to	IN
cord-006229-7yoilsho	808	4	the	the	DT
cord-006229-7yoilsho	808	5	scientific	scientific	JJ
cord-006229-7yoilsho	808	6	relevance	relevance	NN
cord-006229-7yoilsho	808	7	of	of	IN
cord-006229-7yoilsho	808	8	research	research	NN
cord-006229-7yoilsho	808	9	work	work	NN
cord-006229-7yoilsho	808	10	using	use	VBG
cord-006229-7yoilsho	808	11	a	a	DT
cord-006229-7yoilsho	808	12	specific	specific	JJ
cord-006229-7yoilsho	808	13	in	in	IN
cord-006229-7yoilsho	808	14	vitro	vitro	FW
cord-006229-7yoilsho	808	15	method	method	NN
cord-006229-7yoilsho	809	1	provide	provide	VB
cord-006229-7yoilsho	809	2	a	a	DT
cord-006229-7yoilsho	809	3	tool	tool	NN
cord-006229-7yoilsho	809	4	to	to	TO
cord-006229-7yoilsho	809	5	justify	justify	VB
cord-006229-7yoilsho	809	6	,	,	,
cord-006229-7yoilsho	810	1	e.g.	e.g.	RB
cord-006229-7yoilsho	810	2	,	,	,
cord-006229-7yoilsho	810	3	the	the	DT
cord-006229-7yoilsho	810	4	suitability	suitability	NN
cord-006229-7yoilsho	810	5	of	of	IN
cord-006229-7yoilsho	810	6	the	the	DT
cord-006229-7yoilsho	810	7	selected	select	VBN
cord-006229-7yoilsho	810	8	test	test	NN
cord-006229-7yoilsho	810	9	system	system	NN
cord-006229-7yoilsho	810	10	and	and	CC
cord-006229-7yoilsho	810	11	in	in	IN
cord-006229-7yoilsho	810	12	vitro	vitro	FW
cord-006229-7yoilsho	810	13	endpoint(s	endpoint(s	NNP
cord-006229-7yoilsho	810	14	)	)	-RRB-
cord-006229-7yoilsho	810	15	for	for	IN
cord-006229-7yoilsho	810	16	the	the	DT
cord-006229-7yoilsho	810	17	given	give	VBN
cord-006229-7yoilsho	810	18	purpose	purpose	NN
cord-006229-7yoilsho	810	19	;	;	:
cord-006229-7yoilsho	810	20	the	the	DT
cord-006229-7yoilsho	810	21	selection	selection	NN
cord-006229-7yoilsho	810	22	of	of	IN
cord-006229-7yoilsho	810	23	test	test	NN
cord-006229-7yoilsho	810	24	substances	substance	NNS
cord-006229-7yoilsho	810	25	,	,	,
cord-006229-7yoilsho	810	26	positive	positive	JJ
cord-006229-7yoilsho	810	27	and	and	CC
cord-006229-7yoilsho	810	28	negative	negative	JJ
cord-006229-7yoilsho	810	29	controls	control	NNS
cord-006229-7yoilsho	810	30	;	;	:
cord-006229-7yoilsho	810	31	the	the	DT
cord-006229-7yoilsho	810	32	setting	setting	NN
cord-006229-7yoilsho	810	33	and	and	CC
cord-006229-7yoilsho	810	34	control	control	NN
cord-006229-7yoilsho	810	35	of	of	IN
cord-006229-7yoilsho	810	36	test	test	NN
cord-006229-7yoilsho	810	37	concentrations	concentration	NNS
cord-006229-7yoilsho	810	38	;	;	:
cord-006229-7yoilsho	810	39	and	and	CC
cord-006229-7yoilsho	810	40	the	the	DT
cord-006229-7yoilsho	810	41	definition	definition	NN
cord-006229-7yoilsho	810	42	of	of	IN
cord-006229-7yoilsho	810	43	acceptance	acceptance	NN
cord-006229-7yoilsho	810	44	criteria	criterion	NNS
cord-006229-7yoilsho	810	45	to	to	TO
cord-006229-7yoilsho	810	46	determine	determine	VB
cord-006229-7yoilsho	810	47	the	the	DT
cord-006229-7yoilsho	810	48	relevance	relevance	NN
cord-006229-7yoilsho	810	49	of	of	IN
cord-006229-7yoilsho	810	50	test	test	NN
cord-006229-7yoilsho	810	51	results	result	NNS
cord-006229-7yoilsho	810	52	.	.	.
cord-006229-7yoilsho	811	1	The	the	DT
cord-006229-7yoilsho	811	2	proposed	propose	VBN
cord-006229-7yoilsho	811	3	QC	QC	NNP
cord-006229-7yoilsho	811	4	may	may	MD
cord-006229-7yoilsho	811	5	serve	serve	VB
cord-006229-7yoilsho	811	6	as	as	IN
cord-006229-7yoilsho	811	7	a	a	DT
cord-006229-7yoilsho	811	8	framework	framework	NN
cord-006229-7yoilsho	811	9	to	to	TO
cord-006229-7yoilsho	811	10	assess	assess	VB
cord-006229-7yoilsho	811	11	the	the	DT
cord-006229-7yoilsho	811	12	relevance	relevance	NN
cord-006229-7yoilsho	811	13	of	of	IN
cord-006229-7yoilsho	811	14	in	in	FW
cord-006229-7yoilsho	811	15	vitro	vitro	FW
cord-006229-7yoilsho	811	16	methods	method	NNS
cord-006229-7yoilsho	811	17	and	and	CC
cord-006229-7yoilsho	811	18	in	in	IN
cord-006229-7yoilsho	811	19	vitro	vitro	FW
cord-006229-7yoilsho	811	20	research	research	NN
cord-006229-7yoilsho	811	21	work	work	NN
cord-006229-7yoilsho	811	22	.	.	.
cord-006229-7yoilsho	812	1	Thereby	thereby	RB
cord-006229-7yoilsho	812	2	,	,	,
cord-006229-7yoilsho	812	3	they	-PRON-	PRP
cord-006229-7yoilsho	812	4	aim	aim	VBP
cord-006229-7yoilsho	812	5	at	at	IN
cord-006229-7yoilsho	812	6	improving	improve	VBG
cord-006229-7yoilsho	812	7	in	in	IN
cord-006229-7yoilsho	812	8	vitro	vitro	FW
cord-006229-7yoilsho	812	9	predictivity	predictivity	NN
cord-006229-7yoilsho	812	10	of	of	IN
cord-006229-7yoilsho	812	11	in	in	IN
cord-006229-7yoilsho	812	12	vivo	vivo	JJ
cord-006229-7yoilsho	812	13	toxicological	toxicological	JJ
cord-006229-7yoilsho	812	14	effects	effect	NNS
cord-006229-7yoilsho	812	15	,	,	,
cord-006229-7yoilsho	812	16	which	which	WDT
cord-006229-7yoilsho	812	17	in	in	IN
cord-006229-7yoilsho	812	18	return	return	NN
cord-006229-7yoilsho	812	19	contributes	contribute	VBZ
cord-006229-7yoilsho	812	20	to	to	IN
cord-006229-7yoilsho	812	21	reducing	reduce	VBG
cord-006229-7yoilsho	812	22	and	and	CC
cord-006229-7yoilsho	812	23	replacing	replace	VBG
cord-006229-7yoilsho	812	24	the	the	DT
cord-006229-7yoilsho	812	25	need	need	NN
cord-006229-7yoilsho	812	26	for	for	IN
cord-006229-7yoilsho	812	27	animal	animal	NN
cord-006229-7yoilsho	812	28	testing	testing	NN
cord-006229-7yoilsho	812	29	.	.	.
cord-006229-7yoilsho	813	1	[	[	-LRB-
cord-006229-7yoilsho	813	2	1	1	CD
cord-006229-7yoilsho	813	3	]	]	-RRB-
cord-006229-7yoilsho	813	4	Gundert	Gundert	NNP
cord-006229-7yoilsho	813	5	-	-	HYPH
cord-006229-7yoilsho	813	6	Remy	Remy	NNP
cord-006229-7yoilsho	813	7	,	,	,
cord-006229-7yoilsho	813	8	U.	U.	NNP
cord-006229-7yoilsho	813	9	et	et	NNP
cord-006229-7yoilsho	813	10	al	al	NNP
cord-006229-7yoilsho	813	11	.	.	.
cord-006229-7yoilsho	814	1	(	(	-LRB-
cord-006229-7yoilsho	814	2	2015	2015	CD
cord-006229-7yoilsho	814	3	)	)	-RRB-
cord-006229-7yoilsho	814	4	.	.	.
cord-006229-7yoilsho	815	1	Toxicology	Toxicology	NNP
cord-006229-7yoilsho	815	2	:	:	:
cord-006229-7yoilsho	815	3	a	a	DT
cord-006229-7yoilsho	815	4	discipline	discipline	NN
cord-006229-7yoilsho	815	5	in	in	IN
cord-006229-7yoilsho	815	6	need	need	NN
cord-006229-7yoilsho	815	7	of	of	IN
cord-006229-7yoilsho	815	8	academic	academic	JJ
cord-006229-7yoilsho	815	9	anchoring	anchoring	NN
cord-006229-7yoilsho	815	10	-the	-the	DT
cord-006229-7yoilsho	815	11	point	point	NN
cord-006229-7yoilsho	815	12	of	of	IN
cord-006229-7yoilsho	815	13	view	view	NN
cord-006229-7yoilsho	815	14	of	of	IN
cord-006229-7yoilsho	815	15	the	the	DT
cord-006229-7yoilsho	815	16	German	German	NNP
cord-006229-7yoilsho	815	17	Society	Society	NNP
cord-006229-7yoilsho	815	18	of	of	IN
cord-006229-7yoilsho	815	19	Toxicology	Toxicology	NNP
cord-006229-7yoilsho	815	20	.	.	.
cord-006229-7yoilsho	816	1	Arch	Arch	NNP
cord-006229-7yoilsho	816	2	Toxicol	Toxicol	NNP
cord-006229-7yoilsho	816	3	89	89	CD
cord-006229-7yoilsho	816	4	:	:	:
cord-006229-7yoilsho	817	1	1881	1881	CD
cord-006229-7yoilsho	817	2	-	-	SYM
cord-006229-7yoilsho	817	3	93	93	CD
cord-006229-7yoilsho	817	4	.	.	.
cord-006229-7yoilsho	818	1	During	during	IN
cord-006229-7yoilsho	818	2	the	the	DT
cord-006229-7yoilsho	818	3	past	past	JJ
cord-006229-7yoilsho	818	4	decades	decade	NNS
cord-006229-7yoilsho	818	5	,	,	,
cord-006229-7yoilsho	818	6	considerable	considerable	JJ
cord-006229-7yoilsho	818	7	progress	progress	NN
cord-006229-7yoilsho	818	8	has	have	VBZ
cord-006229-7yoilsho	818	9	been	be	VBN
cord-006229-7yoilsho	818	10	made	make	VBN
cord-006229-7yoilsho	818	11	in	in	IN
cord-006229-7yoilsho	818	12	implementing	implement	VBG
cord-006229-7yoilsho	818	13	3R	3R	NNP
cord-006229-7yoilsho	818	14	approaches	approach	NNS
cord-006229-7yoilsho	818	15	in	in	IN
cord-006229-7yoilsho	818	16	routine	routine	JJ
cord-006229-7yoilsho	818	17	safety	safety	NN
cord-006229-7yoilsho	818	18	assessment	assessment	NN
cord-006229-7yoilsho	818	19	.	.	.
cord-006229-7yoilsho	819	1	In	in	IN
cord-006229-7yoilsho	819	2	spite	spite	NN
cord-006229-7yoilsho	819	3	of	of	IN
cord-006229-7yoilsho	819	4	these	these	DT
cord-006229-7yoilsho	819	5	achievements	achievement	NNS
cord-006229-7yoilsho	819	6	,	,	,
cord-006229-7yoilsho	819	7	animal	animal	NN
cord-006229-7yoilsho	819	8	tests	test	NNS
cord-006229-7yoilsho	819	9	still	still	RB
cord-006229-7yoilsho	819	10	need	need	VBP
cord-006229-7yoilsho	819	11	to	to	TO
cord-006229-7yoilsho	819	12	be	be	VB
cord-006229-7yoilsho	819	13	conducted	conduct	VBN
cord-006229-7yoilsho	819	14	if	if	IN
cord-006229-7yoilsho	819	15	legal	legal	JJ
cord-006229-7yoilsho	819	16	requirements	requirement	NNS
cord-006229-7yoilsho	819	17	prescribe	prescribe	VBP
cord-006229-7yoilsho	819	18	in	in	IN
cord-006229-7yoilsho	819	19	vivo	vivo	NN
cord-006229-7yoilsho	819	20	tests	test	NNS
cord-006229-7yoilsho	819	21	or	or	CC
cord-006229-7yoilsho	819	22	if	if	IN
cord-006229-7yoilsho	819	23	no	no	DT
cord-006229-7yoilsho	819	24	reliable	reliable	JJ
cord-006229-7yoilsho	819	25	,	,	,
cord-006229-7yoilsho	819	26	accepted	accepted	JJ
cord-006229-7yoilsho	819	27	alternative	alternative	JJ
cord-006229-7yoilsho	819	28	method	method	NN
cord-006229-7yoilsho	819	29	exists	exist	VBZ
cord-006229-7yoilsho	819	30	.	.	.
cord-006229-7yoilsho	820	1	Efforts	effort	NNS
cord-006229-7yoilsho	820	2	to	to	TO
cord-006229-7yoilsho	820	3	foster	foster	VB
cord-006229-7yoilsho	820	4	3R	3R	NNP
cord-006229-7yoilsho	820	5	approaches	approach	NNS
cord-006229-7yoilsho	820	6	and	and	CC
cord-006229-7yoilsho	820	7	make	make	VB
cord-006229-7yoilsho	820	8	them	-PRON-	PRP
cord-006229-7yoilsho	820	9	'	'	''
cord-006229-7yoilsho	820	10	ready	ready	JJ
cord-006229-7yoilsho	820	11	for	for	IN
cord-006229-7yoilsho	820	12	use	use	NN
cord-006229-7yoilsho	820	13	'	'	``
cord-006229-7yoilsho	820	14	focus	focus	NN
cord-006229-7yoilsho	820	15	on	on	IN
cord-006229-7yoilsho	820	16	three	three	CD
cord-006229-7yoilsho	820	17	levels	level	NNS
cord-006229-7yoilsho	820	18	:	:	:
cord-006229-7yoilsho	820	19	Development	development	NN
cord-006229-7yoilsho	820	20	and	and	CC
cord-006229-7yoilsho	820	21	validation	validation	NN
cord-006229-7yoilsho	820	22	of	of	IN
cord-006229-7yoilsho	820	23	scientific	scientific	JJ
cord-006229-7yoilsho	820	24	methods	method	NNS
cord-006229-7yoilsho	820	25	/	/	SYM
cord-006229-7yoilsho	820	26	strategies	strategy	NNS
cord-006229-7yoilsho	820	27	,	,	,
cord-006229-7yoilsho	820	28	regulatory	regulatory	JJ
cord-006229-7yoilsho	820	29	acceptance	acceptance	NN
cord-006229-7yoilsho	820	30	of	of	IN
cord-006229-7yoilsho	820	31	acknowledged	acknowledge	VBN
cord-006229-7yoilsho	820	32	approaches	approach	NNS
cord-006229-7yoilsho	820	33	and	and	CC
cord-006229-7yoilsho	820	34	global	global	JJ
cord-006229-7yoilsho	820	35	harmonization	harmonization	NN
cord-006229-7yoilsho	820	36	of	of	IN
cord-006229-7yoilsho	820	37	standards	standard	NNS
cord-006229-7yoilsho	820	38	.	.	.
cord-006229-7yoilsho	821	1	Strong	strong	JJ
cord-006229-7yoilsho	821	2	cooperation	cooperation	NN
cord-006229-7yoilsho	821	3	between	between	IN
cord-006229-7yoilsho	821	4	toxicological	toxicological	JJ
cord-006229-7yoilsho	821	5	experts	expert	NNS
cord-006229-7yoilsho	821	6	from	from	IN
cord-006229-7yoilsho	821	7	scientific	scientific	JJ
cord-006229-7yoilsho	821	8	bodies	body	NNS
cord-006229-7yoilsho	821	9	,	,	,
cord-006229-7yoilsho	821	10	national	national	JJ
cord-006229-7yoilsho	821	11	and	and	CC
cord-006229-7yoilsho	821	12	international	international	JJ
cord-006229-7yoilsho	821	13	authorities	authority	NNS
cord-006229-7yoilsho	821	14	and	and	CC
cord-006229-7yoilsho	821	15	industry	industry	NN
cord-006229-7yoilsho	821	16	is	be	VBZ
cord-006229-7yoilsho	821	17	needed	need	VBN
cord-006229-7yoilsho	821	18	to	to	TO
cord-006229-7yoilsho	821	19	advance	advance	VB
cord-006229-7yoilsho	821	20	on	on	IN
cord-006229-7yoilsho	821	21	all	all	DT
cord-006229-7yoilsho	821	22	three	three	CD
cord-006229-7yoilsho	821	23	levels	level	NNS
cord-006229-7yoilsho	821	24	for	for	IN
cord-006229-7yoilsho	821	25	the	the	DT
cord-006229-7yoilsho	821	26	benefit	benefit	NN
cord-006229-7yoilsho	821	27	of	of	IN
cord-006229-7yoilsho	821	28	animal	animal	NN
cord-006229-7yoilsho	821	29	welfare	welfare	NN
cord-006229-7yoilsho	821	30	.	.	.
cord-006229-7yoilsho	822	1	3R	3R	NNP
cord-006229-7yoilsho	822	2	approaches	approach	NNS
cord-006229-7yoilsho	822	3	that	that	WDT
cord-006229-7yoilsho	822	4	have	have	VBP
cord-006229-7yoilsho	822	5	already	already	RB
cord-006229-7yoilsho	822	6	been	be	VBN
cord-006229-7yoilsho	822	7	implemented	implement	VBN
cord-006229-7yoilsho	822	8	in	in	IN
cord-006229-7yoilsho	822	9	routine	routine	JJ
cord-006229-7yoilsho	822	10	safety	safety	NN
cord-006229-7yoilsho	822	11	assessment	assessment	NN
cord-006229-7yoilsho	822	12	of	of	IN
cord-006229-7yoilsho	822	13	consumer	consumer	NN
cord-006229-7yoilsho	822	14	goods	good	NNS
cord-006229-7yoilsho	822	15	do	do	VBP
cord-006229-7yoilsho	822	16	not	not	RB
cord-006229-7yoilsho	822	17	focus	focus	VB
cord-006229-7yoilsho	822	18	solely	solely	RB
cord-006229-7yoilsho	822	19	on	on	IN
cord-006229-7yoilsho	822	20	replacement	replacement	NN
cord-006229-7yoilsho	822	21	of	of	IN
cord-006229-7yoilsho	822	22	animal	animal	NN
cord-006229-7yoilsho	822	23	testing	testing	NN
cord-006229-7yoilsho	822	24	by	by	IN
cord-006229-7yoilsho	822	25	use	use	NN
cord-006229-7yoilsho	822	26	of	of	IN
cord-006229-7yoilsho	822	27	accepted	accept	VBN
cord-006229-7yoilsho	822	28	alternative	alternative	JJ
cord-006229-7yoilsho	822	29	methods	method	NNS
cord-006229-7yoilsho	822	30	.	.	.
cord-006229-7yoilsho	823	1	In	in	IN
cord-006229-7yoilsho	823	2	cases	case	NNS
cord-006229-7yoilsho	823	3	where	where	WRB
cord-006229-7yoilsho	823	4	reliable	reliable	JJ
cord-006229-7yoilsho	823	5	alternative	alternative	JJ
cord-006229-7yoilsho	823	6	approaches	approach	NNS
cord-006229-7yoilsho	823	7	are	be	VBP
cord-006229-7yoilsho	823	8	not	not	RB
cord-006229-7yoilsho	823	9	yet	yet	RB
cord-006229-7yoilsho	823	10	available	available	JJ
cord-006229-7yoilsho	823	11	,	,	,
cord-006229-7yoilsho	823	12	reduction	reduction	NN
cord-006229-7yoilsho	823	13	in	in	IN
cord-006229-7yoilsho	823	14	animal	animal	NN
cord-006229-7yoilsho	823	15	numbers	number	NNS
cord-006229-7yoilsho	823	16	and	and	CC
cord-006229-7yoilsho	823	17	refinement	refinement	NN
cord-006229-7yoilsho	823	18	of	of	IN
cord-006229-7yoilsho	823	19	testing	testing	NN
cord-006229-7yoilsho	823	20	procedures	procedure	NNS
cord-006229-7yoilsho	823	21	can	can	MD
cord-006229-7yoilsho	823	22	be	be	VB
cord-006229-7yoilsho	823	23	achieved	achieve	VBN
cord-006229-7yoilsho	823	24	on	on	IN
cord-006229-7yoilsho	823	25	a	a	DT
cord-006229-7yoilsho	823	26	case	case	NN
cord-006229-7yoilsho	823	27	-	-	HYPH
cord-006229-7yoilsho	823	28	by	by	IN
cord-006229-7yoilsho	823	29	-	-	HYPH
cord-006229-7yoilsho	823	30	case	case	NN
cord-006229-7yoilsho	823	31	basis	basis	NN
cord-006229-7yoilsho	823	32	.	.	.
cord-006229-7yoilsho	824	1	A	a	DT
cord-006229-7yoilsho	824	2	tailor	tailor	NN
cord-006229-7yoilsho	824	3	-	-	HYPH
cord-006229-7yoilsho	824	4	made	make	VBN
cord-006229-7yoilsho	824	5	,	,	,
cord-006229-7yoilsho	824	6	tiered	tiered	JJ
cord-006229-7yoilsho	824	7	testing	testing	NN
cord-006229-7yoilsho	824	8	strategy	strategy	NN
cord-006229-7yoilsho	824	9	is	be	VBZ
cord-006229-7yoilsho	824	10	usually	usually	RB
cord-006229-7yoilsho	824	11	pursued	pursue	VBN
cord-006229-7yoilsho	824	12	that	that	WDT
cord-006229-7yoilsho	824	13	involves	involve	VBZ
cord-006229-7yoilsho	824	14	knowledge	knowledge	NN
cord-006229-7yoilsho	824	15	on	on	IN
cord-006229-7yoilsho	824	16	specific	specific	JJ
cord-006229-7yoilsho	824	17	characteristics	characteristic	NNS
cord-006229-7yoilsho	824	18	of	of	IN
cord-006229-7yoilsho	824	19	the	the	DT
cord-006229-7yoilsho	824	20	test	test	NN
cord-006229-7yoilsho	824	21	item	item	NN
cord-006229-7yoilsho	824	22	and	and	CC
cord-006229-7yoilsho	824	23	makes	make	VBZ
cord-006229-7yoilsho	824	24	use	use	NN
cord-006229-7yoilsho	824	25	of	of	IN
cord-006229-7yoilsho	824	26	all	all	DT
cord-006229-7yoilsho	824	27	available	available	JJ
cord-006229-7yoilsho	824	28	data	datum	NNS
cord-006229-7yoilsho	824	29	,	,	,
cord-006229-7yoilsho	824	30	including	include	VBG
cord-006229-7yoilsho	824	31	details	detail	NNS
cord-006229-7yoilsho	824	32	on	on	IN
cord-006229-7yoilsho	824	33	exposure	exposure	NN
cord-006229-7yoilsho	824	34	and	and	CC
cord-006229-7yoilsho	824	35	results	result	NNS
cord-006229-7yoilsho	824	36	obtained	obtain	VBN
cord-006229-7yoilsho	824	37	with	with	IN
cord-006229-7yoilsho	824	38	structural	structural	JJ
cord-006229-7yoilsho	824	39	homologues	homologue	NNS
cord-006229-7yoilsho	824	40	.	.	.
cord-006229-7yoilsho	825	1	Hurdles	hurdle	NNS
cord-006229-7yoilsho	825	2	to	to	TO
cord-006229-7yoilsho	825	3	apply	apply	VB
cord-006229-7yoilsho	825	4	alternative	alternative	JJ
cord-006229-7yoilsho	825	5	approaches	approach	NNS
cord-006229-7yoilsho	825	6	can	can	MD
cord-006229-7yoilsho	825	7	even	even	RB
cord-006229-7yoilsho	825	8	occur	occur	VB
cord-006229-7yoilsho	825	9	for	for	IN
cord-006229-7yoilsho	825	10	established	establish	VBN
cord-006229-7yoilsho	825	11	methods	method	NNS
cord-006229-7yoilsho	825	12	.	.	.
cord-006229-7yoilsho	826	1	As	as	IN
cord-006229-7yoilsho	826	2	legislations	legislation	NNS
cord-006229-7yoilsho	826	3	give	give	VBP
cord-006229-7yoilsho	826	4	different	different	JJ
cord-006229-7yoilsho	826	5	priority	priority	NN
cord-006229-7yoilsho	826	6	to	to	IN
cord-006229-7yoilsho	826	7	alternative	alternative	JJ
cord-006229-7yoilsho	826	8	approaches	approach	NNS
cord-006229-7yoilsho	826	9	,	,	,
cord-006229-7yoilsho	826	10	it	-PRON-	PRP
cord-006229-7yoilsho	826	11	remains	remain	VBZ
cord-006229-7yoilsho	826	12	challenging	challenge	VBG
cord-006229-7yoilsho	826	13	to	to	TO
cord-006229-7yoilsho	826	14	fulfil	fulfil	VB
cord-006229-7yoilsho	826	15	conflicting	conflict	VBG
cord-006229-7yoilsho	826	16	legal	legal	JJ
cord-006229-7yoilsho	826	17	requirements	requirement	NNS
cord-006229-7yoilsho	826	18	in	in	IN
cord-006229-7yoilsho	826	19	different	different	JJ
cord-006229-7yoilsho	826	20	regions	region	NNS
cord-006229-7yoilsho	826	21	of	of	IN
cord-006229-7yoilsho	826	22	the	the	DT
cord-006229-7yoilsho	826	23	world	world	NN
cord-006229-7yoilsho	826	24	,	,	,
cord-006229-7yoilsho	826	25	or	or	CC
cord-006229-7yoilsho	826	26	even	even	RB
cord-006229-7yoilsho	826	27	to	to	TO
cord-006229-7yoilsho	826	28	address	address	VB
cord-006229-7yoilsho	826	29	horizontal	horizontal	JJ
cord-006229-7yoilsho	826	30	legislations	legislation	NNS
cord-006229-7yoilsho	826	31	of	of	IN
cord-006229-7yoilsho	826	32	the	the	DT
cord-006229-7yoilsho	826	33	same	same	JJ
cord-006229-7yoilsho	826	34	region	region	NN
cord-006229-7yoilsho	826	35	.	.	.
cord-006229-7yoilsho	827	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	827	2	,	,	,
cord-006229-7yoilsho	827	3	successfully	successfully	RB
cord-006229-7yoilsho	827	4	validated	validate	VBN
cord-006229-7yoilsho	827	5	and	and	CC
cord-006229-7yoilsho	827	6	legally	legally	RB
cord-006229-7yoilsho	827	7	implemented	implement	VBN
cord-006229-7yoilsho	827	8	alternative	alternative	JJ
cord-006229-7yoilsho	827	9	approaches	approach	NNS
cord-006229-7yoilsho	827	10	might	may	MD
cord-006229-7yoilsho	827	11	not	not	RB
cord-006229-7yoilsho	827	12	always	always	RB
cord-006229-7yoilsho	827	13	provide	provide	VB
cord-006229-7yoilsho	827	14	the	the	DT
cord-006229-7yoilsho	827	15	safety	safety	NN
cord-006229-7yoilsho	827	16	assessor	assessor	NN
cord-006229-7yoilsho	827	17	with	with	IN
cord-006229-7yoilsho	827	18	meaningful	meaningful	JJ
cord-006229-7yoilsho	827	19	test	test	NN
cord-006229-7yoilsho	827	20	results	result	NNS
cord-006229-7yoilsho	827	21	.	.	.
cord-006229-7yoilsho	828	1	With	with	IN
cord-006229-7yoilsho	828	2	gaining	gain	VBG
cord-006229-7yoilsho	828	3	experience	experience	NN
cord-006229-7yoilsho	828	4	,	,	,
cord-006229-7yoilsho	828	5	limitations	limitation	NNS
cord-006229-7yoilsho	828	6	of	of	IN
cord-006229-7yoilsho	828	7	test	test	NN
cord-006229-7yoilsho	828	8	systems	system	NNS
cord-006229-7yoilsho	828	9	can	can	MD
cord-006229-7yoilsho	828	10	become	become	VB
cord-006229-7yoilsho	828	11	evident	evident	JJ
cord-006229-7yoilsho	828	12	that	that	DT
cord-006229-7yoilsho	828	13	affect	affect	NN
cord-006229-7yoilsho	828	14	for	for	IN
cord-006229-7yoilsho	828	15	example	example	NN
cord-006229-7yoilsho	828	16	the	the	DT
cord-006229-7yoilsho	828	17	applicability	applicability	NN
cord-006229-7yoilsho	828	18	domain	domain	NN
cord-006229-7yoilsho	828	19	of	of	IN
cord-006229-7yoilsho	828	20	the	the	DT
cord-006229-7yoilsho	828	21	method	method	NN
cord-006229-7yoilsho	828	22	,	,	,
cord-006229-7yoilsho	828	23	as	as	IN
cord-006229-7yoilsho	828	24	has	have	VBZ
cord-006229-7yoilsho	828	25	been	be	VBN
cord-006229-7yoilsho	828	26	the	the	DT
cord-006229-7yoilsho	828	27	case	case	NN
cord-006229-7yoilsho	828	28	both	both	CC
cord-006229-7yoilsho	828	29	for	for	IN
cord-006229-7yoilsho	828	30	some	some	DT
cord-006229-7yoilsho	828	31	in	in	IN
cord-006229-7yoilsho	828	32	vitro	vitro	FW
cord-006229-7yoilsho	828	33	and	and	CC
cord-006229-7yoilsho	828	34	in	in	IN
cord-006229-7yoilsho	828	35	vivo	vivo	NN
cord-006229-7yoilsho	828	36	methods	method	NNS
cord-006229-7yoilsho	828	37	.	.	.
cord-006229-7yoilsho	829	1	In	in	IN
cord-006229-7yoilsho	829	2	these	these	DT
cord-006229-7yoilsho	829	3	cases	case	NNS
cord-006229-7yoilsho	829	4	,	,	,
cord-006229-7yoilsho	829	5	the	the	DT
cord-006229-7yoilsho	829	6	new	new	JJ
cord-006229-7yoilsho	829	7	information	information	NN
cord-006229-7yoilsho	829	8	needs	need	VBZ
cord-006229-7yoilsho	829	9	to	to	TO
cord-006229-7yoilsho	829	10	be	be	VB
cord-006229-7yoilsho	829	11	shared	share	VBN
cord-006229-7yoilsho	829	12	not	not	RB
cord-006229-7yoilsho	829	13	only	only	RB
cord-006229-7yoilsho	829	14	among	among	IN
cord-006229-7yoilsho	829	15	safety	safety	NN
cord-006229-7yoilsho	829	16	assessors	assessor	NNS
cord-006229-7yoilsho	829	17	,	,	,
cord-006229-7yoilsho	829	18	but	but	CC
cord-006229-7yoilsho	829	19	also	also	RB
cord-006229-7yoilsho	829	20	with	with	IN
cord-006229-7yoilsho	829	21	method	method	NN
cord-006229-7yoilsho	829	22	developers	developer	NNS
cord-006229-7yoilsho	829	23	and	and	CC
cord-006229-7yoilsho	829	24	regulators	regulator	NNS
cord-006229-7yoilsho	829	25	to	to	TO
cord-006229-7yoilsho	829	26	facilitate	facilitate	VB
cord-006229-7yoilsho	829	27	refinement	refinement	NN
cord-006229-7yoilsho	829	28	of	of	IN
cord-006229-7yoilsho	829	29	scientific	scientific	JJ
cord-006229-7yoilsho	829	30	approaches	approach	NNS
cord-006229-7yoilsho	829	31	and/or	and/or	CC
cord-006229-7yoilsho	829	32	amendments	amendment	NNS
cord-006229-7yoilsho	829	33	of	of	IN
cord-006229-7yoilsho	829	34	regulations	regulation	NNS
cord-006229-7yoilsho	829	35	.	.	.
cord-006229-7yoilsho	830	1	Leibniz	Leibniz	NNP
cord-006229-7yoilsho	830	2	-	-	HYPH
cord-006229-7yoilsho	830	3	Institut	Institut	NNP
cord-006229-7yoilsho	830	4	für	für	IN
cord-006229-7yoilsho	830	5	Arbeitsforschung	Arbeitsforschung	NNP
cord-006229-7yoilsho	830	6	(	(	-LRB-
cord-006229-7yoilsho	830	7	IfADo	IfADo	NNP
cord-006229-7yoilsho	830	8	)	)	-RRB-
cord-006229-7yoilsho	830	9	,	,	,
cord-006229-7yoilsho	830	10	VisTox	VisTox	NNP
cord-006229-7yoilsho	830	11	,	,	,
cord-006229-7yoilsho	830	12	Dortmund	Dortmund	NNP
cord-006229-7yoilsho	830	13	,	,	,
cord-006229-7yoilsho	830	14	Germany	Germany	NNP
cord-006229-7yoilsho	830	15	Two	two	CD
cord-006229-7yoilsho	830	16	-	-	HYPH
cord-006229-7yoilsho	830	17	photon	photon	NN
cord-006229-7yoilsho	830	18	microscopy	microscopy	NN
cord-006229-7yoilsho	830	19	facilitates	facilitate	VBZ
cord-006229-7yoilsho	830	20	imaging	imaging	NN
cord-006229-7yoilsho	830	21	of	of	IN
cord-006229-7yoilsho	830	22	biological	biological	JJ
cord-006229-7yoilsho	830	23	processes	process	NNS
cord-006229-7yoilsho	830	24	in	in	IN
cord-006229-7yoilsho	830	25	vivo	vivo	NN
cord-006229-7yoilsho	830	26	.	.	.
cord-006229-7yoilsho	831	1	Establishing	establish	VBG
cord-006229-7yoilsho	831	2	this	this	DT
cord-006229-7yoilsho	831	3	recent	recent	JJ
cord-006229-7yoilsho	831	4	technique	technique	NN
cord-006229-7yoilsho	831	5	in	in	IN
cord-006229-7yoilsho	831	6	mouse	mouse	NN
cord-006229-7yoilsho	831	7	liver	liver	NN
cord-006229-7yoilsho	831	8	allowed	allow	VBD
cord-006229-7yoilsho	831	9	us	-PRON-	PRP
cord-006229-7yoilsho	831	10	to	to	TO
cord-006229-7yoilsho	831	11	record	record	VB
cord-006229-7yoilsho	831	12	in	in	IN
cord-006229-7yoilsho	831	13	a	a	DT
cord-006229-7yoilsho	831	14	real	real	JJ
cord-006229-7yoilsho	831	15	-	-	HYPH
cord-006229-7yoilsho	831	16	time	time	NN
cord-006229-7yoilsho	831	17	the	the	DT
cord-006229-7yoilsho	831	18	sequence	sequence	NN
cord-006229-7yoilsho	831	19	of	of	IN
cord-006229-7yoilsho	831	20	events	event	NNS
cord-006229-7yoilsho	831	21	during	during	IN
cord-006229-7yoilsho	831	22	acetaminophen	acetaminophen	NN
cord-006229-7yoilsho	831	23	(	(	-LRB-
cord-006229-7yoilsho	831	24	APAP	APAP	NNP
cord-006229-7yoilsho	831	25	)	)	-RRB-
cord-006229-7yoilsho	831	26	induced	induce	VBN
cord-006229-7yoilsho	831	27	-	-	HYPH
cord-006229-7yoilsho	831	28	liver	liver	NN
cord-006229-7yoilsho	831	29	damage	damage	NN
cord-006229-7yoilsho	831	30	.	.	.
cord-006229-7yoilsho	832	1	Although	although	IN
cord-006229-7yoilsho	832	2	APAP	APAP	NNP
cord-006229-7yoilsho	832	3	is	be	VBZ
cord-006229-7yoilsho	832	4	intensively	intensively	RB
cord-006229-7yoilsho	832	5	studied	study	VBN
cord-006229-7yoilsho	832	6	and	and	CC
cord-006229-7yoilsho	832	7	described	describe	VBN
cord-006229-7yoilsho	832	8	in	in	IN
cord-006229-7yoilsho	832	9	vivo	vivo	NNP
cord-006229-7yoilsho	832	10	imaging	imaging	NN
cord-006229-7yoilsho	832	11	revealed	reveal	VBD
cord-006229-7yoilsho	832	12	so	so	RB
cord-006229-7yoilsho	832	13	far	far	RB
cord-006229-7yoilsho	832	14	unknown	unknown	JJ
cord-006229-7yoilsho	832	15	scenarios	scenario	NNS
cord-006229-7yoilsho	832	16	of	of	IN
cord-006229-7yoilsho	832	17	cell	cell	NN
cord-006229-7yoilsho	832	18	death	death	NN
cord-006229-7yoilsho	832	19	.	.	.
cord-006229-7yoilsho	833	1	The	the	DT
cord-006229-7yoilsho	833	2	hepatocytes	hepatocyte	NNS
cord-006229-7yoilsho	833	3	close	close	JJ
cord-006229-7yoilsho	833	4	to	to	IN
cord-006229-7yoilsho	833	5	the	the	DT
cord-006229-7yoilsho	833	6	central	central	JJ
cord-006229-7yoilsho	833	7	vein	vein	NN
cord-006229-7yoilsho	833	8	of	of	IN
cord-006229-7yoilsho	833	9	a	a	DT
cord-006229-7yoilsho	833	10	liver	liver	NN
cord-006229-7yoilsho	833	11	lobule	lobule	NN
cord-006229-7yoilsho	834	1	went	go	VBD
cord-006229-7yoilsho	834	2	within	within	IN
cord-006229-7yoilsho	834	3	hours	hour	NNS
cord-006229-7yoilsho	834	4	into	into	IN
cord-006229-7yoilsho	834	5	cell	cell	NN
cord-006229-7yoilsho	834	6	death	death	NN
cord-006229-7yoilsho	834	7	as	as	IN
cord-006229-7yoilsho	834	8	commonly	commonly	RB
cord-006229-7yoilsho	834	9	described	describe	VBN
cord-006229-7yoilsho	834	10	due	due	IN
cord-006229-7yoilsho	834	11	to	to	IN
cord-006229-7yoilsho	834	12	the	the	DT
cord-006229-7yoilsho	834	13	toxic	toxic	JJ
cord-006229-7yoilsho	834	14	metabolite	metabolite	NN
cord-006229-7yoilsho	834	15	NAPQI	NAPQI	NNP
cord-006229-7yoilsho	834	16	.	.	.
cord-006229-7yoilsho	835	1	Surprisingly	surprisingly	RB
cord-006229-7yoilsho	835	2	,	,	,
cord-006229-7yoilsho	835	3	we	-PRON-	PRP
cord-006229-7yoilsho	835	4	observed	observe	VBD
cord-006229-7yoilsho	835	5	a	a	DT
cord-006229-7yoilsho	835	6	distinct	distinct	JJ
cord-006229-7yoilsho	835	7	way	way	NN
cord-006229-7yoilsho	835	8	of	of	IN
cord-006229-7yoilsho	835	9	cell	cell	NN
cord-006229-7yoilsho	835	10	killing	kill	VBG
cord-006229-7yoilsho	835	11	at	at	IN
cord-006229-7yoilsho	835	12	the	the	DT
cord-006229-7yoilsho	835	13	outer	outer	JJ
cord-006229-7yoilsho	835	14	border	border	NN
cord-006229-7yoilsho	835	15	of	of	IN
cord-006229-7yoilsho	835	16	the	the	DT
cord-006229-7yoilsho	835	17	dead	dead	JJ
cord-006229-7yoilsho	835	18	cell	cell	NN
cord-006229-7yoilsho	835	19	area	area	NN
cord-006229-7yoilsho	835	20	which	which	WDT
cord-006229-7yoilsho	835	21	is	be	VBZ
cord-006229-7yoilsho	835	22	accompanied	accompany	VBN
cord-006229-7yoilsho	835	23	by	by	IN
cord-006229-7yoilsho	835	24	bile	bile	NN
cord-006229-7yoilsho	835	25	acid	acid	NN
cord-006229-7yoilsho	835	26	decompartmentalization	decompartmentalization	NN
cord-006229-7yoilsho	835	27	.	.	.
cord-006229-7yoilsho	836	1	There	there	RB
cord-006229-7yoilsho	836	2	,	,	,
cord-006229-7yoilsho	836	3	within	within	IN
cord-006229-7yoilsho	836	4	an	an	DT
cord-006229-7yoilsho	836	5	hour	hour	NN
cord-006229-7yoilsho	836	6	after	after	IN
cord-006229-7yoilsho	836	7	APAP	APAP	NNP
cord-006229-7yoilsho	836	8	administration	administration	NN
cord-006229-7yoilsho	836	9	dilatation	dilatation	NN
cord-006229-7yoilsho	836	10	of	of	IN
cord-006229-7yoilsho	836	11	bile	bile	NN
cord-006229-7yoilsho	836	12	canaliculi	canaliculi	NNP
cord-006229-7yoilsho	836	13	was	be	VBD
cord-006229-7yoilsho	836	14	observed	observe	VBN
cord-006229-7yoilsho	836	15	.	.	.
cord-006229-7yoilsho	837	1	Subsequently	subsequently	RB
cord-006229-7yoilsho	837	2	,	,	,
cord-006229-7yoilsho	837	3	bile	bile	NN
cord-006229-7yoilsho	837	4	acids	acid	NNS
cord-006229-7yoilsho	837	5	containing	contain	VBG
cord-006229-7yoilsho	837	6	invaginations	invagination	NNS
cord-006229-7yoilsho	837	7	arouse	arouse	VBP
cord-006229-7yoilsho	837	8	from	from	IN
cord-006229-7yoilsho	837	9	the	the	DT
cord-006229-7yoilsho	837	10	apical	apical	JJ
cord-006229-7yoilsho	837	11	side	side	NN
cord-006229-7yoilsho	837	12	of	of	IN
cord-006229-7yoilsho	837	13	a	a	DT
cord-006229-7yoilsho	837	14	hepatocyte	hepatocyte	NN
cord-006229-7yoilsho	837	15	into	into	IN
cord-006229-7yoilsho	837	16	the	the	DT
cord-006229-7yoilsho	837	17	cytosol	cytosol	NN
cord-006229-7yoilsho	837	18	.	.	.
cord-006229-7yoilsho	838	1	These	these	DT
cord-006229-7yoilsho	838	2	invaginations	invagination	NNS
cord-006229-7yoilsho	838	3	ballooned	balloon	VBD
cord-006229-7yoilsho	838	4	until	until	IN
cord-006229-7yoilsho	838	5	the	the	DT
cord-006229-7yoilsho	838	6	bile	bile	NN
cord-006229-7yoilsho	838	7	leaked	leak	VBD
cord-006229-7yoilsho	838	8	into	into	IN
cord-006229-7yoilsho	838	9	the	the	DT
cord-006229-7yoilsho	838	10	hepatocyte	hepatocyte	NN
cord-006229-7yoilsho	838	11	volume	volume	NN
cord-006229-7yoilsho	838	12	and	and	CC
cord-006229-7yoilsho	838	13	subsequently	subsequently	RB
cord-006229-7yoilsho	838	14	the	the	DT
cord-006229-7yoilsho	838	15	plasma	plasma	NN
cord-006229-7yoilsho	838	16	membrane	membrane	NN
cord-006229-7yoilsho	838	17	of	of	IN
cord-006229-7yoilsho	838	18	the	the	DT
cord-006229-7yoilsho	838	19	affected	affect	VBN
cord-006229-7yoilsho	838	20	hepatocytes	hepatocyte	NNS
cord-006229-7yoilsho	838	21	lost	lose	VBD
cord-006229-7yoilsho	838	22	its	-PRON-	PRP$
cord-006229-7yoilsho	838	23	integrity	integrity	NN
cord-006229-7yoilsho	838	24	leading	lead	VBG
cord-006229-7yoilsho	838	25	to	to	IN
cord-006229-7yoilsho	838	26	cell	cell	NN
cord-006229-7yoilsho	838	27	death	death	NN
cord-006229-7yoilsho	838	28	.	.	.
cord-006229-7yoilsho	839	1	This	this	DT
cord-006229-7yoilsho	839	2	mechanism	mechanism	NN
cord-006229-7yoilsho	839	3	emerged	emerge	VBD
cord-006229-7yoilsho	839	4	in	in	IN
cord-006229-7yoilsho	839	5	an	an	DT
cord-006229-7yoilsho	839	6	environment	environment	NN
cord-006229-7yoilsho	839	7	for	for	IN
cord-006229-7yoilsho	839	8	hepatocytes	hepatocyte	NNS
cord-006229-7yoilsho	839	9	where	where	WRB
cord-006229-7yoilsho	839	10	moderate	moderate	JJ
cord-006229-7yoilsho	839	11	NAPQI	NAPQI	NNP
cord-006229-7yoilsho	839	12	levels	level	NNS
cord-006229-7yoilsho	839	13	meet	meet	VBP
cord-006229-7yoilsho	839	14	intracellular	intracellular	JJ
cord-006229-7yoilsho	839	15	high	high	JJ
cord-006229-7yoilsho	839	16	bile	bile	NN
cord-006229-7yoilsho	839	17	salt	salt	NN
cord-006229-7yoilsho	839	18	concentrations	concentration	NNS
cord-006229-7yoilsho	839	19	of	of	IN
cord-006229-7yoilsho	839	20	the	the	DT
cord-006229-7yoilsho	839	21	midzonal	midzonal	JJ
cord-006229-7yoilsho	839	22	region	region	NN
cord-006229-7yoilsho	839	23	.	.	.
cord-006229-7yoilsho	840	1	In	in	IN
cord-006229-7yoilsho	840	2	conclusion	conclusion	NN
cord-006229-7yoilsho	840	3	,	,	,
cord-006229-7yoilsho	840	4	establishing	establish	VBG
cord-006229-7yoilsho	840	5	in	in	IN
cord-006229-7yoilsho	840	6	vivo	vivo	NN
cord-006229-7yoilsho	840	7	imaging	image	VBG
cord-006229-7yoilsho	840	8	in	in	IN
cord-006229-7yoilsho	840	9	mouse	mouse	NN
cord-006229-7yoilsho	840	10	liver	liver	NN
cord-006229-7yoilsho	840	11	enabled	enable	VBD
cord-006229-7yoilsho	840	12	us	-PRON-	PRP
cord-006229-7yoilsho	840	13	to	to	TO
cord-006229-7yoilsho	840	14	identify	identify	VB
cord-006229-7yoilsho	840	15	new	new	JJ
cord-006229-7yoilsho	840	16	cellular	cellular	JJ
cord-006229-7yoilsho	840	17	mechanisms	mechanism	NNS
cord-006229-7yoilsho	840	18	which	which	WDT
cord-006229-7yoilsho	840	19	can	can	MD
cord-006229-7yoilsho	840	20	not	not	RB
cord-006229-7yoilsho	840	21	be	be	VB
cord-006229-7yoilsho	840	22	discovered	discover	VBN
cord-006229-7yoilsho	840	23	by	by	IN
cord-006229-7yoilsho	840	24	conventional	conventional	JJ
cord-006229-7yoilsho	840	25	methods	method	NNS
cord-006229-7yoilsho	840	26	.	.	.
cord-006229-7yoilsho	841	1	Universitätsklinikum	Universitätsklinikum	NNP
cord-006229-7yoilsho	841	2	Düsseldorf	Düsseldorf	NNP
cord-006229-7yoilsho	841	3	,	,	,
cord-006229-7yoilsho	841	4	Institut	Institut	NNP
cord-006229-7yoilsho	841	5	für	für	IN
cord-006229-7yoilsho	841	6	Toxikologie	Toxikologie	NNP
cord-006229-7yoilsho	841	7	,	,	,
cord-006229-7yoilsho	841	8	Düsseldorf	Düsseldorf	NNP
cord-006229-7yoilsho	841	9	,	,	,
cord-006229-7yoilsho	842	1	Germany	Germany	NNP
cord-006229-7yoilsho	842	2	Introduction	Introduction	NNP
cord-006229-7yoilsho	842	3	:	:	:
cord-006229-7yoilsho	843	1	Lung	lung	NN
cord-006229-7yoilsho	843	2	inflammation	inflammation	NN
cord-006229-7yoilsho	843	3	and	and	CC
cord-006229-7yoilsho	843	4	fibrosis	fibrosis	NN
cord-006229-7yoilsho	843	5	are	be	VBP
cord-006229-7yoilsho	843	6	considered	consider	VBN
cord-006229-7yoilsho	843	7	as	as	IN
cord-006229-7yoilsho	843	8	major	major	JJ
cord-006229-7yoilsho	843	9	toxicities	toxicity	NNS
cord-006229-7yoilsho	843	10	after	after	IN
cord-006229-7yoilsho	843	11	thoracic	thoracic	JJ
cord-006229-7yoilsho	843	12	cancer	cancer	NN
cord-006229-7yoilsho	843	13	radiotherapy	radiotherapy	NN
cord-006229-7yoilsho	843	14	.	.	.
cord-006229-7yoilsho	844	1	Up	up	IN
cord-006229-7yoilsho	844	2	to	to	IN
cord-006229-7yoilsho	844	3	now	now	RB
cord-006229-7yoilsho	844	4	effective	effective	JJ
cord-006229-7yoilsho	844	5	pharmacological	pharmacological	JJ
cord-006229-7yoilsho	844	6	interventions	intervention	NNS
cord-006229-7yoilsho	844	7	for	for	IN
cord-006229-7yoilsho	844	8	normal	normal	JJ
cord-006229-7yoilsho	844	9	tissue	tissue	NN
cord-006229-7yoilsho	844	10	protection	protection	NN
cord-006229-7yoilsho	844	11	are	be	VBP
cord-006229-7yoilsho	844	12	largely	largely	RB
cord-006229-7yoilsho	844	13	missing	missing	JJ
cord-006229-7yoilsho	844	14	.	.	.
cord-006229-7yoilsho	845	1	HMG	HMG	NNP
cord-006229-7yoilsho	845	2	-	-	HYPH
cord-006229-7yoilsho	845	3	CoA	CoA	NNP
cord-006229-7yoilsho	845	4	reductase	reductase	NN
cord-006229-7yoilsho	845	5	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	845	6	(	(	-LRB-
cord-006229-7yoilsho	845	7	statins	statin	NNS
cord-006229-7yoilsho	845	8	)	)	-RRB-
cord-006229-7yoilsho	845	9	,	,	,
cord-006229-7yoilsho	845	10	which	which	WDT
cord-006229-7yoilsho	845	11	are	be	VBP
cord-006229-7yoilsho	845	12	used	use	VBN
cord-006229-7yoilsho	845	13	in	in	IN
cord-006229-7yoilsho	845	14	the	the	DT
cord-006229-7yoilsho	845	15	clinic	clinic	NN
cord-006229-7yoilsho	845	16	for	for	IN
cord-006229-7yoilsho	845	17	lipid	lipid	NN
cord-006229-7yoilsho	845	18	-	-	HYPH
cord-006229-7yoilsho	845	19	lowering	lower	VBG
cord-006229-7yoilsho	845	20	purpose	purpose	NN
cord-006229-7yoilsho	845	21	,	,	,
cord-006229-7yoilsho	845	22	are	be	VBP
cord-006229-7yoilsho	845	23	reported	report	VBN
cord-006229-7yoilsho	845	24	to	to	TO
cord-006229-7yoilsho	845	25	have	have	VB
cord-006229-7yoilsho	845	26	multiple	multiple	JJ
cord-006229-7yoilsho	845	27	inhibitory	inhibitory	JJ
cord-006229-7yoilsho	845	28	effects	effect	NNS
cord-006229-7yoilsho	845	29	on	on	IN
cord-006229-7yoilsho	845	30	genotoxic	genotoxic	JJ
cord-006229-7yoilsho	845	31	stress	stress	NN
cord-006229-7yoilsho	845	32	responses	response	NNS
cord-006229-7yoilsho	845	33	.	.	.
cord-006229-7yoilsho	846	1	For	for	IN
cord-006229-7yoilsho	846	2	this	this	DT
cord-006229-7yoilsho	846	3	reason	reason	NN
cord-006229-7yoilsho	846	4	we	-PRON-	PRP
cord-006229-7yoilsho	846	5	aim	aim	VBP
cord-006229-7yoilsho	846	6	to	to	TO
cord-006229-7yoilsho	846	7	investigate	investigate	VB
cord-006229-7yoilsho	846	8	the	the	DT
cord-006229-7yoilsho	846	9	usefulness	usefulness	NN
cord-006229-7yoilsho	846	10	of	of	IN
cord-006229-7yoilsho	846	11	statins	statin	NNS
cord-006229-7yoilsho	846	12	to	to	TO
cord-006229-7yoilsho	846	13	protect	protect	VB
cord-006229-7yoilsho	846	14	normal	normal	JJ
cord-006229-7yoilsho	846	15	lung	lung	NN
cord-006229-7yoilsho	846	16	cells	cell	NNS
cord-006229-7yoilsho	846	17	in	in	IN
cord-006229-7yoilsho	846	18	vitro	vitro	FW
cord-006229-7yoilsho	846	19	and	and	CC
cord-006229-7yoilsho	846	20	lung	lung	NN
cord-006229-7yoilsho	846	21	tissue	tissue	NN
cord-006229-7yoilsho	846	22	in	in	IN
cord-006229-7yoilsho	846	23	vivo	vivo	NN
cord-006229-7yoilsho	846	24	from	from	IN
cord-006229-7yoilsho	846	25	damage	damage	NN
cord-006229-7yoilsho	846	26	provoked	provoke	VBN
cord-006229-7yoilsho	846	27	by	by	IN
cord-006229-7yoilsho	846	28	ionizing	ionize	VBG
cord-006229-7yoilsho	846	29	radiation	radiation	NN
cord-006229-7yoilsho	846	30	(	(	-LRB-
cord-006229-7yoilsho	846	31	IR	IR	NNP
cord-006229-7yoilsho	846	32	)	)	-RRB-
cord-006229-7yoilsho	846	33	.	.	.
cord-006229-7yoilsho	847	1	Methods	method	NNS
cord-006229-7yoilsho	847	2	:	:	:
cord-006229-7yoilsho	848	1	According	accord	VBG
cord-006229-7yoilsho	848	2	to	to	IN
cord-006229-7yoilsho	848	3	clinically	clinically	RB
cord-006229-7yoilsho	848	4	relevant	relevant	JJ
cord-006229-7yoilsho	848	5	anticancer	anticancer	JJ
cord-006229-7yoilsho	848	6	radiation	radiation	NN
cord-006229-7yoilsho	848	7	regimens	regimen	NNS
cord-006229-7yoilsho	848	8	,	,	,
cord-006229-7yoilsho	848	9	we	-PRON-	PRP
cord-006229-7yoilsho	848	10	used	use	VBD
cord-006229-7yoilsho	848	11	fractionated	fractionated	JJ
cord-006229-7yoilsho	848	12	irradiation	irradiation	NN
cord-006229-7yoilsho	848	13	schemes	scheme	NNS
cord-006229-7yoilsho	848	14	(	(	-LRB-
cord-006229-7yoilsho	848	15	4	4	CD
cord-006229-7yoilsho	848	16	x	x	SYM
cord-006229-7yoilsho	848	17	4	4	CD
cord-006229-7yoilsho	848	18	Gy	Gy	NNP
cord-006229-7yoilsho	848	19	)	)	-RRB-
cord-006229-7yoilsho	848	20	for	for	IN
cord-006229-7yoilsho	848	21	both	both	DT
cord-006229-7yoilsho	848	22	in	in	IN
cord-006229-7yoilsho	848	23	vitro	vitro	FW
cord-006229-7yoilsho	848	24	as	as	RB
cord-006229-7yoilsho	848	25	well	well	RB
cord-006229-7yoilsho	848	26	as	as	IN
cord-006229-7yoilsho	848	27	in	in	IN
cord-006229-7yoilsho	848	28	vivo	vivo	NN
cord-006229-7yoilsho	848	29	experiments	experiment	NNS
cord-006229-7yoilsho	848	30	.	.	.
cord-006229-7yoilsho	849	1	We	-PRON-	PRP
cord-006229-7yoilsho	849	2	analyzed	analyze	VBD
cord-006229-7yoilsho	849	3	the	the	DT
cord-006229-7yoilsho	849	4	effect	effect	NN
cord-006229-7yoilsho	849	5	of	of	IN
cord-006229-7yoilsho	849	6	lovastatin	lovastatin	NN
cord-006229-7yoilsho	849	7	on	on	IN
cord-006229-7yoilsho	849	8	IR	IR	NNP
cord-006229-7yoilsho	849	9	-	-	HYPH
cord-006229-7yoilsho	849	10	induced	induce	VBN
cord-006229-7yoilsho	849	11	DNA	dna	NN
cord-006229-7yoilsho	849	12	damage	damage	NN
cord-006229-7yoilsho	849	13	formation	formation	NN
cord-006229-7yoilsho	849	14	and	and	CC
cord-006229-7yoilsho	849	15	repair	repair	NN
cord-006229-7yoilsho	849	16	,	,	,
cord-006229-7yoilsho	849	17	DNA	dna	NN
cord-006229-7yoilsho	849	18	damage	damage	NN
cord-006229-7yoilsho	849	19	response	response	NN
cord-006229-7yoilsho	849	20	(	(	-LRB-
cord-006229-7yoilsho	849	21	DDR	DDR	NNP
cord-006229-7yoilsho	849	22	)	)	-RRB-
cord-006229-7yoilsho	849	23	and	and	CC
cord-006229-7yoilsho	849	24	cell	cell	NN
cord-006229-7yoilsho	849	25	death	death	NN
cord-006229-7yoilsho	849	26	in	in	IN
cord-006229-7yoilsho	849	27	non	non	JJ
cord-006229-7yoilsho	849	28	-	-	JJ
cord-006229-7yoilsho	849	29	proliferating	proliferating	JJ
cord-006229-7yoilsho	849	30	human	human	JJ
cord-006229-7yoilsho	849	31	lung	lung	NN
cord-006229-7yoilsho	849	32	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	849	33	,	,	,
cord-006229-7yoilsho	849	34	epithelial	epithelial	JJ
cord-006229-7yoilsho	849	35	as	as	RB
cord-006229-7yoilsho	849	36	well	well	RB
cord-006229-7yoilsho	849	37	as	as	IN
cord-006229-7yoilsho	849	38	endothelial	endothelial	JJ
cord-006229-7yoilsho	849	39	cells	cell	NNS
cord-006229-7yoilsho	849	40	.	.	.
cord-006229-7yoilsho	850	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	850	2	,	,	,
cord-006229-7yoilsho	850	3	we	-PRON-	PRP
cord-006229-7yoilsho	850	4	established	establish	VBD
cord-006229-7yoilsho	850	5	an	an	DT
cord-006229-7yoilsho	850	6	irradiation	irradiation	NN
cord-006229-7yoilsho	850	7	device	device	NN
cord-006229-7yoilsho	850	8	that	that	WDT
cord-006229-7yoilsho	850	9	is	be	VBZ
cord-006229-7yoilsho	850	10	useful	useful	JJ
cord-006229-7yoilsho	850	11	to	to	TO
cord-006229-7yoilsho	850	12	selectively	selectively	RB
cord-006229-7yoilsho	850	13	irradiate	irradiate	VB
cord-006229-7yoilsho	850	14	the	the	DT
cord-006229-7yoilsho	850	15	right	right	JJ
cord-006229-7yoilsho	850	16	lung	lung	NN
cord-006229-7yoilsho	850	17	of	of	IN
cord-006229-7yoilsho	850	18	mice	mouse	NNS
cord-006229-7yoilsho	850	19	and	and	CC
cord-006229-7yoilsho	850	20	investigated	investigate	VBD
cord-006229-7yoilsho	850	21	the	the	DT
cord-006229-7yoilsho	850	22	influence	influence	NN
cord-006229-7yoilsho	850	23	of	of	IN
cord-006229-7yoilsho	850	24	lovastatin	lovastatin	NN
cord-006229-7yoilsho	850	25	on	on	IN
cord-006229-7yoilsho	850	26	lung	lung	NN
cord-006229-7yoilsho	850	27	damage	damage	NN
cord-006229-7yoilsho	850	28	following	follow	VBG
cord-006229-7yoilsho	850	29	fractionated	fractionated	JJ
cord-006229-7yoilsho	850	30	and	and	CC
cord-006229-7yoilsho	850	31	selective	selective	JJ
cord-006229-7yoilsho	850	32	irradiation	irradiation	NN
cord-006229-7yoilsho	850	33	of	of	IN
cord-006229-7yoilsho	850	34	the	the	DT
cord-006229-7yoilsho	850	35	lung	lung	NN
cord-006229-7yoilsho	850	36	in	in	IN
cord-006229-7yoilsho	850	37	vivo	vivo	NNP
cord-006229-7yoilsho	850	38	(	(	-LRB-
cord-006229-7yoilsho	850	39	BALB	BALB	NNP
cord-006229-7yoilsho	850	40	/	/	SYM
cord-006229-7yoilsho	850	41	c	c	NN
cord-006229-7yoilsho	850	42	mice	mouse	NNS
cord-006229-7yoilsho	850	43	)	)	-RRB-
cord-006229-7yoilsho	850	44	.	.	.
cord-006229-7yoilsho	851	1	Results	result	NNS
cord-006229-7yoilsho	851	2	:	:	:
cord-006229-7yoilsho	852	1	Compared	compare	VBN
cord-006229-7yoilsho	852	2	to	to	IN
cord-006229-7yoilsho	852	3	lung	lung	NN
cord-006229-7yoilsho	852	4	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	852	5	and	and	CC
cord-006229-7yoilsho	852	6	epithelial	epithelial	JJ
cord-006229-7yoilsho	852	7	cells	cell	NNS
cord-006229-7yoilsho	852	8	,	,	,
cord-006229-7yoilsho	852	9	endothelial	endothelial	JJ
cord-006229-7yoilsho	852	10	cells	cell	NNS
cord-006229-7yoilsho	852	11	exhibited	exhibit	VBD
cord-006229-7yoilsho	852	12	the	the	DT
cord-006229-7yoilsho	852	13	highest	high	JJS
cord-006229-7yoilsho	852	14	radiosensitivity	radiosensitivity	NN
cord-006229-7yoilsho	852	15	and	and	CC
cord-006229-7yoilsho	852	16	underwent	undergo	VBD
cord-006229-7yoilsho	852	17	IR	IR	NNP
cord-006229-7yoilsho	852	18	-	-	HYPH
cord-006229-7yoilsho	852	19	induced	induce	VBN
cord-006229-7yoilsho	852	20	apoptosis	apoptosis	NN
cord-006229-7yoilsho	852	21	which	which	WDT
cord-006229-7yoilsho	852	22	was	be	VBD
cord-006229-7yoilsho	852	23	partly	partly	RB
cord-006229-7yoilsho	852	24	prevented	prevent	VBN
cord-006229-7yoilsho	852	25	by	by	IN
cord-006229-7yoilsho	852	26	lovastatin	lovastatin	NN
cord-006229-7yoilsho	852	27	.	.	.
cord-006229-7yoilsho	853	1	By	by	IN
cord-006229-7yoilsho	853	2	contrast	contrast	NN
cord-006229-7yoilsho	853	3	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	853	4	and	and	CC
cord-006229-7yoilsho	853	5	epithelial	epithelial	JJ
cord-006229-7yoilsho	853	6	cells	cell	NNS
cord-006229-7yoilsho	853	7	did	do	VBD
cord-006229-7yoilsho	853	8	not	not	RB
cord-006229-7yoilsho	853	9	undergo	undergo	VB
cord-006229-7yoilsho	853	10	apoptosis	apoptosis	NN
cord-006229-7yoilsho	853	11	upon	upon	IN
cord-006229-7yoilsho	853	12	irradiation	irradiation	NN
cord-006229-7yoilsho	853	13	.	.	.
cord-006229-7yoilsho	854	1	Lovastatin	Lovastatin	NNP
cord-006229-7yoilsho	854	2	did	do	VBD
cord-006229-7yoilsho	854	3	not	not	RB
cord-006229-7yoilsho	854	4	affect	affect	VB
cord-006229-7yoilsho	854	5	initial	initial	JJ
cord-006229-7yoilsho	854	6	DNA	dna	NN
cord-006229-7yoilsho	854	7	damage	damage	NN
cord-006229-7yoilsho	854	8	formation	formation	NN
cord-006229-7yoilsho	854	9	in	in	IN
cord-006229-7yoilsho	854	10	any	any	DT
cord-006229-7yoilsho	854	11	of	of	IN
cord-006229-7yoilsho	854	12	these	these	DT
cord-006229-7yoilsho	854	13	cells	cell	NNS
cord-006229-7yoilsho	854	14	.	.	.
cord-006229-7yoilsho	855	1	In	in	IN
cord-006229-7yoilsho	855	2	all	all	DT
cord-006229-7yoilsho	855	3	three	three	CD
cord-006229-7yoilsho	855	4	lung	lung	NN
cord-006229-7yoilsho	855	5	cell	cell	NN
cord-006229-7yoilsho	855	6	types	type	NNS
cord-006229-7yoilsho	855	7	lovastatin	lovastatin	NN
cord-006229-7yoilsho	855	8	enhanced	enhance	VBD
cord-006229-7yoilsho	855	9	the	the	DT
cord-006229-7yoilsho	855	10	repair	repair	NN
cord-006229-7yoilsho	855	11	of	of	IN
cord-006229-7yoilsho	855	12	DNA	dna	NN
cord-006229-7yoilsho	855	13	double	double	JJ
cord-006229-7yoilsho	855	14	-	-	HYPH
cord-006229-7yoilsho	855	15	strand	strand	NN
cord-006229-7yoilsho	855	16	breaks	break	NNS
cord-006229-7yoilsho	855	17	as	as	IN
cord-006229-7yoilsho	855	18	analyzed	analyze	VBD
cord-006229-7yoilsho	855	19	24	24	CD
cord-006229-7yoilsho	855	20	h	h	NN
cord-006229-7yoilsho	855	21	after	after	IN
cord-006229-7yoilsho	855	22	the	the	DT
cord-006229-7yoilsho	855	23	last	last	JJ
cord-006229-7yoilsho	855	24	irradiation	irradiation	NN
cord-006229-7yoilsho	855	25	by	by	IN
cord-006229-7yoilsho	855	26	γH2AX	γH2AX	NNP
cord-006229-7yoilsho	855	27	nuclear	nuclear	JJ
cord-006229-7yoilsho	855	28	foci	foci	NN
cord-006229-7yoilsho	855	29	formation	formation	NN
cord-006229-7yoilsho	855	30	.	.	.
cord-006229-7yoilsho	856	1	Depending	depend	VBG
cord-006229-7yoilsho	856	2	on	on	IN
cord-006229-7yoilsho	856	3	the	the	DT
cord-006229-7yoilsho	856	4	cell	cell	NN
cord-006229-7yoilsho	856	5	type	type	NN
cord-006229-7yoilsho	856	6	lovastatin	lovastatin	NN
cord-006229-7yoilsho	856	7	affected	affect	VBD
cord-006229-7yoilsho	856	8	various	various	JJ
cord-006229-7yoilsho	856	9	components	component	NNS
cord-006229-7yoilsho	856	10	of	of	IN
cord-006229-7yoilsho	856	11	the	the	DT
cord-006229-7yoilsho	856	12	DDR	ddr	NN
cord-006229-7yoilsho	856	13	machinery	machinery	NN
cord-006229-7yoilsho	856	14	in	in	IN
cord-006229-7yoilsho	856	15	vitro	vitro	FW
cord-006229-7yoilsho	856	16	.	.	.
cord-006229-7yoilsho	857	1	In	in	IN
cord-006229-7yoilsho	857	2	vivo	vivo	NN
cord-006229-7yoilsho	857	3	,	,	,
cord-006229-7yoilsho	857	4	lovastatin	lovastatin	NN
cord-006229-7yoilsho	857	5	prevented	prevent	VBD
cord-006229-7yoilsho	857	6	IR	IR	NNP
cord-006229-7yoilsho	857	7	-	-	HYPH
cord-006229-7yoilsho	857	8	mediated	mediate	VBN
cord-006229-7yoilsho	857	9	increase	increase	NN
cord-006229-7yoilsho	857	10	in	in	IN
cord-006229-7yoilsho	857	11	breathing	breathing	NN
cord-006229-7yoilsho	857	12	frequency	frequency	NN
cord-006229-7yoilsho	857	13	as	as	IN
cord-006229-7yoilsho	857	14	determined	determine	VBD
cord-006229-7yoilsho	857	15	two	two	CD
cord-006229-7yoilsho	857	16	and	and	CC
cord-006229-7yoilsho	857	17	four	four	CD
cord-006229-7yoilsho	857	18	weeks	week	NNS
cord-006229-7yoilsho	857	19	after	after	IN
cord-006229-7yoilsho	857	20	fractionated	fractionated	JJ
cord-006229-7yoilsho	857	21	irradiation	irradiation	NN
cord-006229-7yoilsho	857	22	.	.	.
cord-006229-7yoilsho	858	1	Moreover	moreover	RB
cord-006229-7yoilsho	858	2	,	,	,
cord-006229-7yoilsho	858	3	statin	statin	NN
cord-006229-7yoilsho	858	4	treatment	treatment	NN
cord-006229-7yoilsho	858	5	attenuated	attenuate	VBD
cord-006229-7yoilsho	858	6	the	the	DT
cord-006229-7yoilsho	858	7	level	level	NN
cord-006229-7yoilsho	858	8	of	of	IN
cord-006229-7yoilsho	858	9	residual	residual	JJ
cord-006229-7yoilsho	858	10	DNA	dna	NN
cord-006229-7yoilsho	858	11	damage	damage	NN
cord-006229-7yoilsho	858	12	and	and	CC
cord-006229-7yoilsho	858	13	IR	IR	NNP
cord-006229-7yoilsho	858	14	-	-	HYPH
cord-006229-7yoilsho	858	15	induced	induce	VBN
cord-006229-7yoilsho	858	16	apoptosis	apoptosis	NN
cord-006229-7yoilsho	858	17	as	as	IN
cord-006229-7yoilsho	858	18	analyzed	analyze	VBN
cord-006229-7yoilsho	858	19	four	four	CD
cord-006229-7yoilsho	858	20	weeks	week	NNS
cord-006229-7yoilsho	858	21	after	after	IN
cord-006229-7yoilsho	858	22	irradiation	irradiation	NN
cord-006229-7yoilsho	858	23	.	.	.
cord-006229-7yoilsho	859	1	These	these	DT
cord-006229-7yoilsho	859	2	results	result	NNS
cord-006229-7yoilsho	859	3	were	be	VBD
cord-006229-7yoilsho	859	4	mimicked	mimic	VBN
cord-006229-7yoilsho	859	5	when	when	WRB
cord-006229-7yoilsho	859	6	EHT1864	EHT1864	NNP
cord-006229-7yoilsho	859	7	,	,	,
cord-006229-7yoilsho	859	8	a	a	DT
cord-006229-7yoilsho	859	9	small	small	JJ
cord-006229-7yoilsho	859	10	molecule	molecule	NN
cord-006229-7yoilsho	859	11	inhibitor	inhibitor	NN
cord-006229-7yoilsho	859	12	of	of	IN
cord-006229-7yoilsho	859	13	the	the	DT
cord-006229-7yoilsho	859	14	small	small	JJ
cord-006229-7yoilsho	859	15	Rho	Rho	NNP
cord-006229-7yoilsho	859	16	-	-	HYPH
cord-006229-7yoilsho	859	17	GTPase	GTPase	NNP
cord-006229-7yoilsho	859	18	Rac1	Rac1	NNP
cord-006229-7yoilsho	859	19	,	,	,
cord-006229-7yoilsho	859	20	was	be	VBD
cord-006229-7yoilsho	859	21	applied	apply	VBN
cord-006229-7yoilsho	859	22	in	in	IN
cord-006229-7yoilsho	859	23	vivo	vivo	NN
cord-006229-7yoilsho	859	24	,	,	,
cord-006229-7yoilsho	859	25	pointing	point	VBG
cord-006229-7yoilsho	859	26	to	to	IN
cord-006229-7yoilsho	859	27	an	an	DT
cord-006229-7yoilsho	859	28	involvement	involvement	NN
cord-006229-7yoilsho	859	29	of	of	IN
cord-006229-7yoilsho	859	30	Rac1	Rac1	NNP
cord-006229-7yoilsho	859	31	in	in	IN
cord-006229-7yoilsho	859	32	statin	statin	NN
cord-006229-7yoilsho	859	33	-	-	HYPH
cord-006229-7yoilsho	859	34	mediated	mediate	VBN
cord-006229-7yoilsho	859	35	radioprotective	radioprotective	JJ
cord-006229-7yoilsho	859	36	effects	effect	NNS
cord-006229-7yoilsho	859	37	.	.	.
cord-006229-7yoilsho	860	1	Conclusion	conclusion	NN
cord-006229-7yoilsho	860	2	:	:	:
cord-006229-7yoilsho	860	3	Bearing	bear	VBG
cord-006229-7yoilsho	860	4	in	in	IN
cord-006229-7yoilsho	860	5	mind	mind	NN
cord-006229-7yoilsho	860	6	that	that	IN
cord-006229-7yoilsho	860	7	statins	statin	NNS
cord-006229-7yoilsho	860	8	are	be	VBP
cord-006229-7yoilsho	860	9	well	well	RB
cord-006229-7yoilsho	860	10	tolerated	tolerate	VBN
cord-006229-7yoilsho	860	11	in	in	IN
cord-006229-7yoilsho	860	12	humans	human	NNS
cord-006229-7yoilsho	861	1	,	,	,
cord-006229-7yoilsho	861	2	we	-PRON-	PRP
cord-006229-7yoilsho	861	3	suggest	suggest	VBP
cord-006229-7yoilsho	861	4	the	the	DT
cord-006229-7yoilsho	861	5	application	application	NN
cord-006229-7yoilsho	861	6	of	of	IN
cord-006229-7yoilsho	861	7	statins	statin	NNS
cord-006229-7yoilsho	861	8	as	as	IN
cord-006229-7yoilsho	861	9	a	a	DT
cord-006229-7yoilsho	861	10	promising	promising	JJ
cord-006229-7yoilsho	861	11	pharmacological	pharmacological	JJ
cord-006229-7yoilsho	861	12	strategy	strategy	NN
cord-006229-7yoilsho	861	13	for	for	IN
cord-006229-7yoilsho	861	14	the	the	DT
cord-006229-7yoilsho	861	15	prevention	prevention	NN
cord-006229-7yoilsho	861	16	of	of	IN
cord-006229-7yoilsho	861	17	irradiation	irradiation	NN
cord-006229-7yoilsho	861	18	-	-	HYPH
cord-006229-7yoilsho	861	19	induced	induce	VBN
cord-006229-7yoilsho	861	20	damage	damage	NN
cord-006229-7yoilsho	861	21	of	of	IN
cord-006229-7yoilsho	861	22	the	the	DT
cord-006229-7yoilsho	861	23	lung	lung	NN
cord-006229-7yoilsho	861	24	.	.	.
cord-006229-7yoilsho	862	1	Targeted	target	VBN
cord-006229-7yoilsho	862	2	genome	genome	NN
cord-006229-7yoilsho	862	3	engineering	engineering	NN
cord-006229-7yoilsho	862	4	by	by	IN
cord-006229-7yoilsho	862	5	CRISPR	CRISPR	NNP
cord-006229-7yoilsho	862	6	/	/	SYM
cord-006229-7yoilsho	862	7	Cas9	Cas9	NNP
cord-006229-7yoilsho	862	8	is	be	VBZ
cord-006229-7yoilsho	862	9	an	an	DT
cord-006229-7yoilsho	862	10	evolving	evolve	VBG
cord-006229-7yoilsho	862	11	tool	tool	NN
cord-006229-7yoilsho	862	12	for	for	IN
cord-006229-7yoilsho	862	13	generating	generate	VBG
cord-006229-7yoilsho	862	14	specific	specific	JJ
cord-006229-7yoilsho	862	15	knockout	knockout	NN
cord-006229-7yoilsho	862	16	cell	cell	NN
cord-006229-7yoilsho	862	17	lines	line	NNS
cord-006229-7yoilsho	862	18	.	.	.
cord-006229-7yoilsho	863	1	Co	co	NN
cord-006229-7yoilsho	863	2	-	-	NN
cord-006229-7yoilsho	863	3	expression	expression	NN
cord-006229-7yoilsho	864	1	of	of	IN
cord-006229-7yoilsho	864	2	CRISPR	CRISPR	NNP
cord-006229-7yoilsho	864	3	/	/	SYM
cord-006229-7yoilsho	864	4	Cas9	Cas9	NNP
cord-006229-7yoilsho	864	5	allows	allow	VBZ
cord-006229-7yoilsho	864	6	for	for	IN
cord-006229-7yoilsho	864	7	efficient	efficient	JJ
cord-006229-7yoilsho	864	8	DNA	dna	NN
cord-006229-7yoilsho	864	9	cleavage	cleavage	NN
cord-006229-7yoilsho	864	10	and	and	CC
cord-006229-7yoilsho	864	11	introduction	introduction	NN
cord-006229-7yoilsho	864	12	of	of	IN
cord-006229-7yoilsho	864	13	so	so	RB
cord-006229-7yoilsho	864	14	called	call	VBN
cord-006229-7yoilsho	864	15	indel	indel	NN
cord-006229-7yoilsho	864	16	mutations	mutation	NNS
cord-006229-7yoilsho	864	17	(	(	-LRB-
cord-006229-7yoilsho	864	18	insertion	insertion	NN
cord-006229-7yoilsho	864	19	/	/	SYM
cord-006229-7yoilsho	864	20	deletion	deletion	NN
cord-006229-7yoilsho	864	21	point	point	NN
cord-006229-7yoilsho	864	22	mutations	mutation	NNS
cord-006229-7yoilsho	864	23	)	)	-RRB-
cord-006229-7yoilsho	864	24	that	that	WDT
cord-006229-7yoilsho	864	25	lead	lead	VBP
cord-006229-7yoilsho	864	26	to	to	IN
cord-006229-7yoilsho	864	27	either	either	CC
cord-006229-7yoilsho	864	28	misfolded	misfolde	VBN
cord-006229-7yoilsho	864	29	non	non	JJ
cord-006229-7yoilsho	864	30	-	-	JJ
cord-006229-7yoilsho	864	31	functional	functional	JJ
cord-006229-7yoilsho	864	32	proteins	protein	NNS
cord-006229-7yoilsho	864	33	or	or	CC
cord-006229-7yoilsho	864	34	complete	complete	JJ
cord-006229-7yoilsho	864	35	knockout	knockout	NN
cord-006229-7yoilsho	864	36	.	.	.
cord-006229-7yoilsho	865	1	We	-PRON-	PRP
cord-006229-7yoilsho	865	2	exploited	exploit	VBD
cord-006229-7yoilsho	865	3	this	this	DT
cord-006229-7yoilsho	865	4	tool	tool	NN
cord-006229-7yoilsho	865	5	to	to	TO
cord-006229-7yoilsho	865	6	generate	generate	VB
cord-006229-7yoilsho	865	7	a	a	DT
cord-006229-7yoilsho	865	8	Bid	bid	NN
cord-006229-7yoilsho	865	9	(	(	-LRB-
cord-006229-7yoilsho	865	10	BH3-interacting	bh3-interacte	VBG
cord-006229-7yoilsho	865	11	domain	domain	NN
cord-006229-7yoilsho	865	12	death	death	NN
cord-006229-7yoilsho	865	13	agonist	agonist	NN
cord-006229-7yoilsho	865	14	)	)	-RRB-
cord-006229-7yoilsho	865	15	knockout	knockout	NN
cord-006229-7yoilsho	865	16	cell	cell	NN
cord-006229-7yoilsho	865	17	line	line	NN
cord-006229-7yoilsho	865	18	in	in	IN
cord-006229-7yoilsho	865	19	neuronal	neuronal	JJ
cord-006229-7yoilsho	865	20	HT-22	HT-22	NNP
cord-006229-7yoilsho	865	21	cells	cell	NNS
cord-006229-7yoilsho	865	22	.	.	.
cord-006229-7yoilsho	866	1	Bid	Bid	NNP
cord-006229-7yoilsho	866	2	has	have	VBZ
cord-006229-7yoilsho	866	3	been	be	VBN
cord-006229-7yoilsho	866	4	shown	show	VBN
cord-006229-7yoilsho	866	5	to	to	TO
cord-006229-7yoilsho	866	6	be	be	VB
cord-006229-7yoilsho	866	7	involved	involve	VBN
cord-006229-7yoilsho	866	8	in	in	IN
cord-006229-7yoilsho	866	9	regulated	regulated	JJ
cord-006229-7yoilsho	866	10	cell	cell	NN
cord-006229-7yoilsho	866	11	death	death	NN
cord-006229-7yoilsho	866	12	pathways	pathway	NNS
cord-006229-7yoilsho	866	13	like	like	IN
cord-006229-7yoilsho	866	14	oxytosis	oxytosis	NN
cord-006229-7yoilsho	866	15	where	where	WRB
cord-006229-7yoilsho	866	16	its	-PRON-	PRP$
cord-006229-7yoilsho	866	17	activation	activation	NN
cord-006229-7yoilsho	866	18	mediates	mediate	VBZ
cord-006229-7yoilsho	866	19	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	866	20	demise	demise	NN
cord-006229-7yoilsho	866	21	,	,	,
cord-006229-7yoilsho	866	22	subsequent	subsequent	JJ
cord-006229-7yoilsho	866	23	release	release	NN
cord-006229-7yoilsho	866	24	of	of	IN
cord-006229-7yoilsho	866	25	Apoptosis	apoptosis	NN
cord-006229-7yoilsho	866	26	inducing	induce	VBG
cord-006229-7yoilsho	866	27	factor	factor	NN
cord-006229-7yoilsho	866	28	(	(	-LRB-
cord-006229-7yoilsho	866	29	AIF	AIF	NNP
cord-006229-7yoilsho	866	30	)	)	-RRB-
cord-006229-7yoilsho	866	31	and	and	CC
cord-006229-7yoilsho	866	32	cell	cell	NN
cord-006229-7yoilsho	866	33	death	death	NN
cord-006229-7yoilsho	866	34	.	.	.
cord-006229-7yoilsho	867	1	In	in	IN
cord-006229-7yoilsho	867	2	the	the	DT
cord-006229-7yoilsho	867	3	cell	cell	NN
cord-006229-7yoilsho	867	4	death	death	NN
cord-006229-7yoilsho	867	5	model	model	NN
cord-006229-7yoilsho	867	6	of	of	IN
cord-006229-7yoilsho	867	7	oxytosis	oxytosis	NN
cord-006229-7yoilsho	867	8	the	the	DT
cord-006229-7yoilsho	867	9	cystine	cystine	NN
cord-006229-7yoilsho	867	10	/	/	SYM
cord-006229-7yoilsho	867	11	glutamate	glutamate	NN
cord-006229-7yoilsho	867	12	antiporter	antiporter	NNP
cord-006229-7yoilsho	867	13	(	(	-LRB-
cord-006229-7yoilsho	867	14	X	X	NNP
cord-006229-7yoilsho	867	15	c	c	NN
cord-006229-7yoilsho	867	16	-	-	:
cord-006229-7yoilsho	867	17	)	)	-RRB-
cord-006229-7yoilsho	867	18	is	be	VBZ
cord-006229-7yoilsho	867	19	inhibited	inhibit	VBN
cord-006229-7yoilsho	867	20	by	by	IN
cord-006229-7yoilsho	867	21	high	high	JJ
cord-006229-7yoilsho	867	22	extracellular	extracellular	JJ
cord-006229-7yoilsho	867	23	glutamate	glutamate	NN
cord-006229-7yoilsho	867	24	concentrations	concentration	NNS
cord-006229-7yoilsho	867	25	.	.	.
cord-006229-7yoilsho	868	1	Following	follow	VBG
cord-006229-7yoilsho	868	2	events	event	NNS
cord-006229-7yoilsho	868	3	such	such	JJ
cord-006229-7yoilsho	868	4	as	as	IN
cord-006229-7yoilsho	868	5	increasing	increase	VBG
cord-006229-7yoilsho	868	6	lipid	lipid	NN
cord-006229-7yoilsho	868	7	peroxidation	peroxidation	NN
cord-006229-7yoilsho	868	8	and	and	CC
cord-006229-7yoilsho	868	9	ROS	ROS	NNP
cord-006229-7yoilsho	868	10	production	production	NN
cord-006229-7yoilsho	868	11	resemble	resemble	VBP
cord-006229-7yoilsho	868	12	major	major	JJ
cord-006229-7yoilsho	868	13	characteristics	characteristic	NNS
cord-006229-7yoilsho	868	14	of	of	IN
cord-006229-7yoilsho	868	15	another	another	DT
cord-006229-7yoilsho	868	16	emerging	emerge	VBG
cord-006229-7yoilsho	868	17	cell	cell	NN
cord-006229-7yoilsho	868	18	death	death	NN
cord-006229-7yoilsho	868	19	pathway	pathway	NN
cord-006229-7yoilsho	868	20	,	,	,
cord-006229-7yoilsho	868	21	called	call	VBN
cord-006229-7yoilsho	868	22	ferroptosis	ferroptosis	NN
cord-006229-7yoilsho	868	23	.	.	.
cord-006229-7yoilsho	869	1	In	in	IN
cord-006229-7yoilsho	869	2	this	this	DT
cord-006229-7yoilsho	869	3	study	study	NN
cord-006229-7yoilsho	869	4	we	-PRON-	PRP
cord-006229-7yoilsho	869	5	generated	generate	VBD
cord-006229-7yoilsho	869	6	a	a	DT
cord-006229-7yoilsho	869	7	Bid	Bid	NNP
cord-006229-7yoilsho	869	8	CRISPR	CRISPR	NNP
cord-006229-7yoilsho	869	9	/	/	SYM
cord-006229-7yoilsho	869	10	Cas9-knockout	cas9-knockout	RP
cord-006229-7yoilsho	869	11	cell	cell	NN
cord-006229-7yoilsho	869	12	line	line	NN
cord-006229-7yoilsho	869	13	to	to	TO
cord-006229-7yoilsho	869	14	elucidate	elucidate	VB
cord-006229-7yoilsho	869	15	the	the	DT
cord-006229-7yoilsho	869	16	role	role	NN
cord-006229-7yoilsho	869	17	of	of	IN
cord-006229-7yoilsho	869	18	Bid	Bid	NNP
cord-006229-7yoilsho	869	19	as	as	IN
cord-006229-7yoilsho	869	20	a	a	DT
cord-006229-7yoilsho	869	21	potential	potential	JJ
cord-006229-7yoilsho	869	22	link	link	NN
cord-006229-7yoilsho	869	23	of	of	IN
cord-006229-7yoilsho	869	24	oxytosis	oxytosis	NN
cord-006229-7yoilsho	869	25	and	and	CC
cord-006229-7yoilsho	869	26	ferroptosis	ferroptosis	NN
cord-006229-7yoilsho	869	27	in	in	IN
cord-006229-7yoilsho	869	28	the	the	DT
cord-006229-7yoilsho	869	29	HT-22	HT-22	NNP
cord-006229-7yoilsho	869	30	cell	cell	NN
cord-006229-7yoilsho	869	31	line	line	NN
cord-006229-7yoilsho	869	32	.	.	.
cord-006229-7yoilsho	870	1	In	in	IN
cord-006229-7yoilsho	870	2	order	order	NN
cord-006229-7yoilsho	870	3	to	to	TO
cord-006229-7yoilsho	870	4	investigate	investigate	VB
cord-006229-7yoilsho	870	5	the	the	DT
cord-006229-7yoilsho	870	6	potential	potential	JJ
cord-006229-7yoilsho	870	7	mechanistic	mechanistic	JJ
cord-006229-7yoilsho	870	8	overlap	overlap	NN
cord-006229-7yoilsho	870	9	at	at	IN
cord-006229-7yoilsho	870	10	the	the	DT
cord-006229-7yoilsho	870	11	level	level	NN
cord-006229-7yoilsho	870	12	of	of	IN
cord-006229-7yoilsho	870	13	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	870	14	death	death	NN
cord-006229-7yoilsho	870	15	pathways	pathway	NNS
cord-006229-7yoilsho	870	16	,	,	,
cord-006229-7yoilsho	870	17	we	-PRON-	PRP
cord-006229-7yoilsho	870	18	induced	induce	VBD
cord-006229-7yoilsho	870	19	oxytosis	oxytosis	NN
cord-006229-7yoilsho	870	20	with	with	IN
cord-006229-7yoilsho	870	21	glutamate	glutamate	NN
cord-006229-7yoilsho	870	22	or	or	CC
cord-006229-7yoilsho	870	23	ferroptosis	ferroptosis	NN
cord-006229-7yoilsho	870	24	with	with	IN
cord-006229-7yoilsho	870	25	erastin	erastin	NNS
cord-006229-7yoilsho	870	26	in	in	IN
cord-006229-7yoilsho	870	27	wild	wild	JJ
cord-006229-7yoilsho	870	28	-	-	HYPH
cord-006229-7yoilsho	870	29	type	type	NN
cord-006229-7yoilsho	870	30	cells	cell	NNS
cord-006229-7yoilsho	870	31	and	and	CC
cord-006229-7yoilsho	870	32	analyzed	analyze	VBD
cord-006229-7yoilsho	870	33	the	the	DT
cord-006229-7yoilsho	870	34	respective	respective	JJ
cord-006229-7yoilsho	870	35	effects	effect	NNS
cord-006229-7yoilsho	870	36	of	of	IN
cord-006229-7yoilsho	870	37	the	the	DT
cord-006229-7yoilsho	870	38	well	well	RB
cord-006229-7yoilsho	870	39	-	-	HYPH
cord-006229-7yoilsho	870	40	established	establish	VBN
cord-006229-7yoilsho	870	41	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	870	42	ferrostatin-1	ferrostatin-1	NNP
cord-006229-7yoilsho	870	43	and	and	CC
cord-006229-7yoilsho	870	44	the	the	DT
cord-006229-7yoilsho	870	45	Bid	Bid	NNP
cord-006229-7yoilsho	870	46	inhibitor	inhibitor	NN
cord-006229-7yoilsho	870	47	Bi-6c9	bi-6c9	NN
cord-006229-7yoilsho	870	48	on	on	IN
cord-006229-7yoilsho	870	49	cell	cell	NN
cord-006229-7yoilsho	870	50	death	death	NN
cord-006229-7yoilsho	870	51	and	and	CC
cord-006229-7yoilsho	870	52	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	870	53	paradigms	paradigm	NNS
cord-006229-7yoilsho	870	54	.	.	.
cord-006229-7yoilsho	871	1	These	these	DT
cord-006229-7yoilsho	871	2	results	result	NNS
cord-006229-7yoilsho	871	3	were	be	VBD
cord-006229-7yoilsho	871	4	then	then	RB
cord-006229-7yoilsho	871	5	compared	compare	VBN
cord-006229-7yoilsho	871	6	to	to	IN
cord-006229-7yoilsho	871	7	the	the	DT
cord-006229-7yoilsho	871	8	effects	effect	NNS
cord-006229-7yoilsho	871	9	of	of	IN
cord-006229-7yoilsho	871	10	glutamate	glutamate	NN
cord-006229-7yoilsho	871	11	or	or	CC
cord-006229-7yoilsho	871	12	erastin	erastin	NNS
cord-006229-7yoilsho	871	13	in	in	IN
cord-006229-7yoilsho	871	14	CRISPR	CRISPR	NNP
cord-006229-7yoilsho	871	15	/	/	SYM
cord-006229-7yoilsho	871	16	Cas9-Bid	Cas9-Bid	NNP
cord-006229-7yoilsho	871	17	-	-	HYPH
cord-006229-7yoilsho	871	18	knockout	knockout	NN
cord-006229-7yoilsho	871	19	cells	cell	NNS
cord-006229-7yoilsho	871	20	.	.	.
cord-006229-7yoilsho	872	1	Bi-6c9	Bi-6c9	NNP
cord-006229-7yoilsho	872	2	inhibited	inhibit	VBN
cord-006229-7yoilsho	872	3	glutamate	glutamate	NN
cord-006229-7yoilsho	872	4	-	-	HYPH
cord-006229-7yoilsho	872	5	induced	induce	VBN
cord-006229-7yoilsho	872	6	morphological	morphological	JJ
cord-006229-7yoilsho	872	7	changes	change	NNS
cord-006229-7yoilsho	872	8	of	of	IN
cord-006229-7yoilsho	872	9	HT-22	HT-22	NNP
cord-006229-7yoilsho	872	10	cells	cell	NNS
cord-006229-7yoilsho	872	11	and	and	CC
cord-006229-7yoilsho	872	12	also	also	RB
cord-006229-7yoilsho	872	13	prevented	prevent	VBD
cord-006229-7yoilsho	872	14	cell	cell	NN
cord-006229-7yoilsho	872	15	death	death	NN
cord-006229-7yoilsho	872	16	as	as	IN
cord-006229-7yoilsho	872	17	assessed	assess	VBN
cord-006229-7yoilsho	872	18	using	use	VBG
cord-006229-7yoilsho	872	19	the	the	DT
cord-006229-7yoilsho	872	20	MTT	MTT	NNP
cord-006229-7yoilsho	872	21	assay	assay	NN
cord-006229-7yoilsho	872	22	and	and	CC
cord-006229-7yoilsho	872	23	Annexin	Annexin	NNP
cord-006229-7yoilsho	872	24	V	V	NNP
cord-006229-7yoilsho	872	25	/	/	SYM
cord-006229-7yoilsho	872	26	PI	pi	NN
cord-006229-7yoilsho	872	27	staining	staining	NN
cord-006229-7yoilsho	872	28	.	.	.
cord-006229-7yoilsho	873	1	Similar	similar	JJ
cord-006229-7yoilsho	873	2	results	result	NNS
cord-006229-7yoilsho	873	3	were	be	VBD
cord-006229-7yoilsho	873	4	observed	observe	VBN
cord-006229-7yoilsho	873	5	with	with	IN
cord-006229-7yoilsho	873	6	ferrostatin-1	ferrostatin-1	NNP
cord-006229-7yoilsho	873	7	in	in	IN
cord-006229-7yoilsho	873	8	the	the	DT
cord-006229-7yoilsho	873	9	model	model	NN
cord-006229-7yoilsho	873	10	of	of	IN
cord-006229-7yoilsho	873	11	erastin	erastin	NNP
cord-006229-7yoilsho	873	12	-	-	HYPH
cord-006229-7yoilsho	873	13	induced	induce	VBN
cord-006229-7yoilsho	873	14	ferroptosis	ferroptosis	NN
cord-006229-7yoilsho	873	15	.	.	.
cord-006229-7yoilsho	874	1	Subsequent	subsequent	JJ
cord-006229-7yoilsho	874	2	FACS	FACS	NNP
cord-006229-7yoilsho	874	3	analysis	analysis	NN
cord-006229-7yoilsho	874	4	of	of	IN
cord-006229-7yoilsho	874	5	lipid	lipid	NN
cord-006229-7yoilsho	874	6	peroxidation	peroxidation	NN
cord-006229-7yoilsho	874	7	by	by	IN
cord-006229-7yoilsho	874	8	BODIPY	BODIPY	NNP
cord-006229-7yoilsho	874	9	staining	stain	VBG
cord-006229-7yoilsho	874	10	demonstrated	demonstrate	VBD
cord-006229-7yoilsho	874	11	that	that	IN
cord-006229-7yoilsho	874	12	Bi-6c9	bi-6c9	NN
cord-006229-7yoilsho	874	13	abolishes	abolish	VBZ
cord-006229-7yoilsho	874	14	lipid	lipid	NN
cord-006229-7yoilsho	874	15	peroxide	peroxide	NN
cord-006229-7yoilsho	874	16	formation	formation	NN
cord-006229-7yoilsho	874	17	in	in	IN
cord-006229-7yoilsho	874	18	the	the	DT
cord-006229-7yoilsho	874	19	erastin	erastin	NNP
cord-006229-7yoilsho	874	20	model	model	NN
cord-006229-7yoilsho	874	21	and	and	CC
cord-006229-7yoilsho	874	22	ferrostatin-1	ferrostatin-1	NNP
cord-006229-7yoilsho	874	23	in	in	IN
cord-006229-7yoilsho	874	24	the	the	DT
cord-006229-7yoilsho	874	25	model	model	NN
cord-006229-7yoilsho	874	26	of	of	IN
cord-006229-7yoilsho	874	27	oxytosis	oxytosis	NN
cord-006229-7yoilsho	874	28	.	.	.
cord-006229-7yoilsho	875	1	FACS	FACS	NNP
cord-006229-7yoilsho	875	2	analysis	analysis	NN
cord-006229-7yoilsho	875	3	was	be	VBD
cord-006229-7yoilsho	875	4	further	further	RB
cord-006229-7yoilsho	875	5	employed	employ	VBN
cord-006229-7yoilsho	875	6	for	for	IN
cord-006229-7yoilsho	875	7	the	the	DT
cord-006229-7yoilsho	875	8	detection	detection	NN
cord-006229-7yoilsho	875	9	of	of	IN
cord-006229-7yoilsho	875	10	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	875	11	ROS	ROS	NNP
cord-006229-7yoilsho	875	12	formation	formation	NN
cord-006229-7yoilsho	875	13	.	.	.
cord-006229-7yoilsho	876	1	MitoSOX	mitosox	LS
cord-006229-7yoilsho	876	2	staining	staining	NN
cord-006229-7yoilsho	876	3	revealed	reveal	VBD
cord-006229-7yoilsho	876	4	a	a	DT
cord-006229-7yoilsho	876	5	significantly	significantly	RB
cord-006229-7yoilsho	876	6	decreased	decrease	VBN
cord-006229-7yoilsho	876	7	production	production	NN
cord-006229-7yoilsho	876	8	of	of	IN
cord-006229-7yoilsho	876	9	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	876	10	ROS	ROS	NNP
cord-006229-7yoilsho	876	11	by	by	IN
cord-006229-7yoilsho	876	12	Bi-6c9	bi-6c9	NN
cord-006229-7yoilsho	876	13	and	and	CC
cord-006229-7yoilsho	876	14	ferrostatin-1	ferrostatin-1	NNP
cord-006229-7yoilsho	876	15	in	in	IN
cord-006229-7yoilsho	876	16	the	the	DT
cord-006229-7yoilsho	876	17	respective	respective	JJ
cord-006229-7yoilsho	876	18	model	model	NN
cord-006229-7yoilsho	876	19	systems	system	NNS
cord-006229-7yoilsho	876	20	.	.	.
cord-006229-7yoilsho	877	1	Investigating	investigate	VBG
cord-006229-7yoilsho	877	2	the	the	DT
cord-006229-7yoilsho	877	3	CRISPR	CRISPR	NNP
cord-006229-7yoilsho	877	4	/	/	SYM
cord-006229-7yoilsho	877	5	Cas9-Bid	Cas9-Bid	NNP
cord-006229-7yoilsho	877	6	-	-	HYPH
cord-006229-7yoilsho	877	7	knockout	knockout	NN
cord-006229-7yoilsho	877	8	HT-22	HT-22	NNP
cord-006229-7yoilsho	877	9	cell	cell	NN
cord-006229-7yoilsho	877	10	line	line	NN
cord-006229-7yoilsho	877	11	revealed	reveal	VBD
cord-006229-7yoilsho	877	12	that	that	IN
cord-006229-7yoilsho	877	13	Bid	Bid	NNP
cord-006229-7yoilsho	877	14	knockout	knockout	NN
cord-006229-7yoilsho	877	15	prevented	prevent	VBD
cord-006229-7yoilsho	877	16	cell	cell	NN
cord-006229-7yoilsho	877	17	death	death	NN
cord-006229-7yoilsho	877	18	,	,	,
cord-006229-7yoilsho	877	19	lipid	lipid	NN
cord-006229-7yoilsho	877	20	peroxidation	peroxidation	NN
cord-006229-7yoilsho	877	21	and	and	CC
cord-006229-7yoilsho	877	22	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	877	23	toxicity	toxicity	NN
cord-006229-7yoilsho	877	24	in	in	IN
cord-006229-7yoilsho	877	25	both	both	DT
cord-006229-7yoilsho	877	26	model	model	NN
cord-006229-7yoilsho	877	27	systems	system	NNS
cord-006229-7yoilsho	877	28	of	of	IN
cord-006229-7yoilsho	877	29	cell	cell	NN
cord-006229-7yoilsho	877	30	death	death	NN
cord-006229-7yoilsho	877	31	,	,	,
cord-006229-7yoilsho	877	32	oxytosis	oxytosis	NN
cord-006229-7yoilsho	877	33	and	and	CC
cord-006229-7yoilsho	877	34	ferroptosis	ferroptosis	NN
cord-006229-7yoilsho	877	35	.	.	.
cord-006229-7yoilsho	878	1	In	in	IN
cord-006229-7yoilsho	878	2	conclusion	conclusion	NN
cord-006229-7yoilsho	878	3	,	,	,
cord-006229-7yoilsho	878	4	the	the	DT
cord-006229-7yoilsho	878	5	present	present	JJ
cord-006229-7yoilsho	878	6	study	study	NN
cord-006229-7yoilsho	878	7	exposes	expose	VBZ
cord-006229-7yoilsho	878	8	Bid	Bid	NNP
cord-006229-7yoilsho	878	9	as	as	IN
cord-006229-7yoilsho	878	10	a	a	DT
cord-006229-7yoilsho	878	11	pivotal	pivotal	JJ
cord-006229-7yoilsho	878	12	molecular	molecular	JJ
cord-006229-7yoilsho	878	13	link	link	NN
cord-006229-7yoilsho	878	14	between	between	IN
cord-006229-7yoilsho	878	15	the	the	DT
cord-006229-7yoilsho	878	16	previously	previously	RB
cord-006229-7yoilsho	878	17	separated	separate	VBN
cord-006229-7yoilsho	878	18	cell	cell	NN
cord-006229-7yoilsho	878	19	death	death	NN
cord-006229-7yoilsho	878	20	pathways	pathway	NNS
cord-006229-7yoilsho	878	21	oxytosis	oxytosis	NN
cord-006229-7yoilsho	878	22	and	and	CC
cord-006229-7yoilsho	878	23	ferroptosis	ferroptosis	NN
cord-006229-7yoilsho	878	24	at	at	IN
cord-006229-7yoilsho	878	25	the	the	DT
cord-006229-7yoilsho	878	26	level	level	NN
cord-006229-7yoilsho	878	27	of	of	IN
cord-006229-7yoilsho	878	28	mitochondria	mitochondrion	NNS
cord-006229-7yoilsho	878	29	.	.	.
cord-006229-7yoilsho	879	1	Parkinson	Parkinson	NNP
cord-006229-7yoilsho	879	2	's	's	POS
cord-006229-7yoilsho	879	3	disease	disease	NN
cord-006229-7yoilsho	879	4	is	be	VBZ
cord-006229-7yoilsho	879	5	a	a	DT
cord-006229-7yoilsho	879	6	common	common	JJ
cord-006229-7yoilsho	879	7	neurodegenerative	neurodegenerative	JJ
cord-006229-7yoilsho	879	8	movement	movement	NN
cord-006229-7yoilsho	879	9	disorder	disorder	NN
cord-006229-7yoilsho	879	10	characterized	characterize	VBN
cord-006229-7yoilsho	879	11	by	by	IN
cord-006229-7yoilsho	879	12	midbrain	midbrain	NN
cord-006229-7yoilsho	879	13	dopaminergic	dopaminergic	JJ
cord-006229-7yoilsho	879	14	neuronal	neuronal	JJ
cord-006229-7yoilsho	879	15	loss	loss	NN
cord-006229-7yoilsho	879	16	in	in	IN
cord-006229-7yoilsho	879	17	the	the	DT
cord-006229-7yoilsho	879	18	substantia	substantia	NN
cord-006229-7yoilsho	879	19	nigra	nigra	NNP
cord-006229-7yoilsho	879	20	that	that	WDT
cord-006229-7yoilsho	879	21	has	have	VBZ
cord-006229-7yoilsho	879	22	been	be	VBN
cord-006229-7yoilsho	879	23	linked	link	VBN
cord-006229-7yoilsho	879	24	to	to	IN
cord-006229-7yoilsho	879	25	alpha	alpha	NN
cord-006229-7yoilsho	879	26	-	-	HYPH
cord-006229-7yoilsho	879	27	synuclein	synuclein	NN
cord-006229-7yoilsho	879	28	toxicity	toxicity	NN
cord-006229-7yoilsho	879	29	.	.	.
cord-006229-7yoilsho	880	1	However	however	RB
cord-006229-7yoilsho	880	2	,	,	,
cord-006229-7yoilsho	880	3	the	the	DT
cord-006229-7yoilsho	880	4	molecular	molecular	JJ
cord-006229-7yoilsho	880	5	mechanisms	mechanism	NNS
cord-006229-7yoilsho	880	6	underlying	underlie	VBG
cord-006229-7yoilsho	880	7	alphasynuclein	alphasynuclein	RB
cord-006229-7yoilsho	880	8	-	-	HYPH
cord-006229-7yoilsho	880	9	mediated	mediate	VBN
cord-006229-7yoilsho	880	10	toxicity	toxicity	NN
cord-006229-7yoilsho	880	11	in	in	IN
cord-006229-7yoilsho	880	12	human	human	JJ
cord-006229-7yoilsho	880	13	dopaminergic	dopaminergic	JJ
cord-006229-7yoilsho	880	14	neuronal	neuronal	JJ
cord-006229-7yoilsho	880	15	loss	loss	NN
cord-006229-7yoilsho	880	16	are	be	VBP
cord-006229-7yoilsho	880	17	not	not	RB
cord-006229-7yoilsho	880	18	well	well	RB
cord-006229-7yoilsho	880	19	defined	define	VBN
cord-006229-7yoilsho	880	20	.	.	.
cord-006229-7yoilsho	881	1	The	the	DT
cord-006229-7yoilsho	881	2	goal	goal	NN
cord-006229-7yoilsho	881	3	of	of	IN
cord-006229-7yoilsho	881	4	this	this	DT
cord-006229-7yoilsho	881	5	study	study	NN
cord-006229-7yoilsho	881	6	was	be	VBD
cord-006229-7yoilsho	881	7	to	to	TO
cord-006229-7yoilsho	881	8	investigate	investigate	VB
cord-006229-7yoilsho	881	9	the	the	DT
cord-006229-7yoilsho	881	10	deleterious	deleterious	JJ
cord-006229-7yoilsho	881	11	effects	effect	NNS
cord-006229-7yoilsho	881	12	of	of	IN
cord-006229-7yoilsho	881	13	alpha	alpha	NN
cord-006229-7yoilsho	881	14	synuclein	synuclein	NNP
cord-006229-7yoilsho	881	15	in	in	IN
cord-006229-7yoilsho	881	16	particular	particular	JJ
cord-006229-7yoilsho	881	17	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	881	18	toxicity	toxicity	NN
cord-006229-7yoilsho	881	19	in	in	IN
cord-006229-7yoilsho	881	20	human	human	JJ
cord-006229-7yoilsho	881	21	dopaminergic	dopaminergic	NN
cord-006229-7yoilsho	881	22	cells	cell	NNS
cord-006229-7yoilsho	881	23	.	.	.
cord-006229-7yoilsho	882	1	Therefore	therefore	RB
cord-006229-7yoilsho	882	2	,	,	,
cord-006229-7yoilsho	882	3	we	-PRON-	PRP
cord-006229-7yoilsho	882	4	have	have	VBP
cord-006229-7yoilsho	882	5	generated	generate	VBN
cord-006229-7yoilsho	882	6	neuron	neuron	NN
cord-006229-7yoilsho	882	7	specific	specific	JJ
cord-006229-7yoilsho	882	8	,	,	,
cord-006229-7yoilsho	882	9	adeno	adeno	NNP
cord-006229-7yoilsho	882	10	associated	associate	VBD
cord-006229-7yoilsho	882	11	virus	virus	NN
cord-006229-7yoilsho	882	12	type	type	NN
cord-006229-7yoilsho	882	13	2	2	CD
cord-006229-7yoilsho	882	14	(	(	-LRB-
cord-006229-7yoilsho	882	15	AAV2	AAV2	NNP
cord-006229-7yoilsho	882	16	)	)	-RRB-
cord-006229-7yoilsho	882	17	expressing	express	VBG
cord-006229-7yoilsho	882	18	cytosolic	cytosolic	JJ
cord-006229-7yoilsho	882	19	as	as	RB
cord-006229-7yoilsho	882	20	well	well	RB
cord-006229-7yoilsho	882	21	as	as	IN
cord-006229-7yoilsho	882	22	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	882	23	targeted	target	VBN
cord-006229-7yoilsho	882	24	alpha	alpha	NN
cord-006229-7yoilsho	882	25	synuclein	synuclein	NNP
cord-006229-7yoilsho	882	26	and	and	CC
cord-006229-7yoilsho	882	27	EGFP	EGFP	NNP
cord-006229-7yoilsho	882	28	expressing	express	VBG
cord-006229-7yoilsho	882	29	viruses	virus	NNS
cord-006229-7yoilsho	882	30	used	use	VBN
cord-006229-7yoilsho	882	31	as	as	IN
cord-006229-7yoilsho	882	32	respective	respective	JJ
cord-006229-7yoilsho	882	33	controls	control	NNS
cord-006229-7yoilsho	882	34	.	.	.
cord-006229-7yoilsho	883	1	Overexpression	overexpression	NN
cord-006229-7yoilsho	883	2	of	of	IN
cord-006229-7yoilsho	883	3	both	both	DT
cord-006229-7yoilsho	883	4	,	,	,
cord-006229-7yoilsho	883	5	the	the	DT
cord-006229-7yoilsho	883	6	cytosolic	cytosolic	JJ
cord-006229-7yoilsho	883	7	and	and	CC
cord-006229-7yoilsho	883	8	the	the	DT
cord-006229-7yoilsho	883	9	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	883	10	variants	variant	NNS
cord-006229-7yoilsho	883	11	of	of	IN
cord-006229-7yoilsho	883	12	alpha	alpha	NNP
cord-006229-7yoilsho	883	13	synuclein	synuclein	NNP
cord-006229-7yoilsho	883	14	severely	severely	RB
cord-006229-7yoilsho	883	15	disrupted	disrupt	VBD
cord-006229-7yoilsho	883	16	the	the	DT
cord-006229-7yoilsho	883	17	dendritic	dendritic	JJ
cord-006229-7yoilsho	883	18	network	network	NN
cord-006229-7yoilsho	883	19	,	,	,
cord-006229-7yoilsho	883	20	induced	induce	VBN
cord-006229-7yoilsho	883	21	loss	loss	NN
cord-006229-7yoilsho	883	22	of	of	IN
cord-006229-7yoilsho	883	23	cellular	cellular	JJ
cord-006229-7yoilsho	883	24	ATP	ATP	NNP
cord-006229-7yoilsho	883	25	,	,	,
cord-006229-7yoilsho	883	26	enhanced	enhance	VBN
cord-006229-7yoilsho	883	27	mitochondrial	mitochondrial	NN
cord-006229-7yoilsho	883	28	ROS	ROS	NNP
cord-006229-7yoilsho	883	29	production	production	NN
cord-006229-7yoilsho	883	30	,	,	,
cord-006229-7yoilsho	883	31	and	and	CC
cord-006229-7yoilsho	883	32	was	be	VBD
cord-006229-7yoilsho	883	33	associated	associate	VBN
cord-006229-7yoilsho	883	34	with	with	IN
cord-006229-7yoilsho	883	35	activation	activation	NN
cord-006229-7yoilsho	883	36	of	of	IN
cord-006229-7yoilsho	883	37	caspases	caspase	NNS
cord-006229-7yoilsho	883	38	and	and	CC
cord-006229-7yoilsho	883	39	dopaminergic	dopaminergic	JJ
cord-006229-7yoilsho	883	40	cell	cell	NN
cord-006229-7yoilsho	883	41	death	death	NN
cord-006229-7yoilsho	883	42	in	in	IN
cord-006229-7yoilsho	883	43	a	a	DT
cord-006229-7yoilsho	883	44	time	time	NN
cord-006229-7yoilsho	883	45	-	-	HYPH
cord-006229-7yoilsho	883	46	dependent	dependent	JJ
cord-006229-7yoilsho	883	47	manner	manner	NN
cord-006229-7yoilsho	883	48	.	.	.
cord-006229-7yoilsho	884	1	In	in	IN
cord-006229-7yoilsho	884	2	addition	addition	NN
cord-006229-7yoilsho	884	3	,	,	,
cord-006229-7yoilsho	884	4	real	real	JJ
cord-006229-7yoilsho	884	5	-	-	HYPH
cord-006229-7yoilsho	884	6	time	time	NN
cord-006229-7yoilsho	884	7	analysis	analysis	NN
cord-006229-7yoilsho	884	8	of	of	IN
cord-006229-7yoilsho	884	9	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	884	10	bioenergetics	bioenergetic	NNS
cord-006229-7yoilsho	884	11	using	use	VBG
cord-006229-7yoilsho	884	12	the	the	DT
cord-006229-7yoilsho	884	13	Seahorse	Seahorse	NNP
cord-006229-7yoilsho	884	14	Bioscience	Bioscience	NNP
cord-006229-7yoilsho	884	15	system	system	NN
cord-006229-7yoilsho	884	16	following	follow	VBG
cord-006229-7yoilsho	884	17	AAV	AAV	NNP
cord-006229-7yoilsho	884	18	infection	infection	NN
cord-006229-7yoilsho	884	19	elicited	elicit	VBD
cord-006229-7yoilsho	884	20	a	a	DT
cord-006229-7yoilsho	884	21	complete	complete	JJ
cord-006229-7yoilsho	884	22	damage	damage	NN
cord-006229-7yoilsho	884	23	to	to	IN
cord-006229-7yoilsho	884	24	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	884	25	respiration	respiration	NN
cord-006229-7yoilsho	884	26	capacity	capacity	NN
cord-006229-7yoilsho	884	27	in	in	IN
cord-006229-7yoilsho	884	28	the	the	DT
cord-006229-7yoilsho	884	29	dopaminergic	dopaminergic	JJ
cord-006229-7yoilsho	884	30	neurons	neuron	NNS
cord-006229-7yoilsho	884	31	.	.	.
cord-006229-7yoilsho	885	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	885	2	results	result	NNS
cord-006229-7yoilsho	885	3	suggested	suggest	VBD
cord-006229-7yoilsho	885	4	that	that	IN
cord-006229-7yoilsho	885	5	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	885	6	targeted	target	VBN
cord-006229-7yoilsho	885	7	expression	expression	NN
cord-006229-7yoilsho	885	8	of	of	IN
cord-006229-7yoilsho	885	9	alpha	alpha	NNP
cord-006229-7yoilsho	885	10	synuclein	synuclein	NNP
cord-006229-7yoilsho	885	11	appeared	appear	VBD
cord-006229-7yoilsho	885	12	to	to	TO
cord-006229-7yoilsho	885	13	be	be	VB
cord-006229-7yoilsho	885	14	more	more	RBR
cord-006229-7yoilsho	885	15	toxic	toxic	JJ
cord-006229-7yoilsho	885	16	than	than	IN
cord-006229-7yoilsho	885	17	the	the	DT
cord-006229-7yoilsho	885	18	cytosolic	cytosolic	JJ
cord-006229-7yoilsho	885	19	form	form	NN
cord-006229-7yoilsho	885	20	of	of	IN
cord-006229-7yoilsho	885	21	alpha	alpha	NN
cord-006229-7yoilsho	885	22	synuclein	synuclein	NNP
cord-006229-7yoilsho	885	23	.	.	.
cord-006229-7yoilsho	886	1	In	in	IN
cord-006229-7yoilsho	886	2	addition	addition	NN
cord-006229-7yoilsho	886	3	,	,	,
cord-006229-7yoilsho	886	4	ultrastructural	ultrastructural	JJ
cord-006229-7yoilsho	886	5	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	886	6	morphological	morphological	JJ
cord-006229-7yoilsho	886	7	analysis	analysis	NN
cord-006229-7yoilsho	886	8	by	by	IN
cord-006229-7yoilsho	886	9	transmission	transmission	NN
cord-006229-7yoilsho	886	10	electron	electron	NN
cord-006229-7yoilsho	886	11	microscopy	microscopy	NNP
cord-006229-7yoilsho	886	12	illustrated	illustrate	VBD
cord-006229-7yoilsho	886	13	a	a	DT
cord-006229-7yoilsho	886	14	number	number	NN
cord-006229-7yoilsho	886	15	of	of	IN
cord-006229-7yoilsho	886	16	deformed	deformed	JJ
cord-006229-7yoilsho	886	17	cristae	cristae	NN
cord-006229-7yoilsho	886	18	in	in	IN
cord-006229-7yoilsho	886	19	cells	cell	NNS
cord-006229-7yoilsho	886	20	expressing	express	VBG
cord-006229-7yoilsho	886	21	the	the	DT
cord-006229-7yoilsho	886	22	cytosolic	cytosolic	JJ
cord-006229-7yoilsho	886	23	alpha	alpha	NN
cord-006229-7yoilsho	886	24	synuclein	synuclein	NN
cord-006229-7yoilsho	886	25	and	and	CC
cord-006229-7yoilsho	886	26	a	a	DT
cord-006229-7yoilsho	886	27	complete	complete	JJ
cord-006229-7yoilsho	886	28	loss	loss	NN
cord-006229-7yoilsho	886	29	of	of	IN
cord-006229-7yoilsho	886	30	cristae	cristae	NN
cord-006229-7yoilsho	886	31	structure	structure	NN
cord-006229-7yoilsho	886	32	and	and	CC
cord-006229-7yoilsho	886	33	massively	massively	RB
cord-006229-7yoilsho	886	34	swollen	swollen	JJ
cord-006229-7yoilsho	886	35	mitochondria	mitochondrion	NNS
cord-006229-7yoilsho	886	36	following	follow	VBG
cord-006229-7yoilsho	886	37	the	the	DT
cord-006229-7yoilsho	886	38	expression	expression	NN
cord-006229-7yoilsho	886	39	of	of	IN
cord-006229-7yoilsho	886	40	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	886	41	targeted	target	VBN
cord-006229-7yoilsho	886	42	alpha	alpha	NN
cord-006229-7yoilsho	886	43	synuclein	synuclein	NN
cord-006229-7yoilsho	886	44	in	in	IN
cord-006229-7yoilsho	886	45	the	the	DT
cord-006229-7yoilsho	886	46	human	human	JJ
cord-006229-7yoilsho	886	47	dopaminergic	dopaminergic	NN
cord-006229-7yoilsho	886	48	neurons	neuron	NNS
cord-006229-7yoilsho	886	49	.	.	.
cord-006229-7yoilsho	887	1	In	in	IN
cord-006229-7yoilsho	887	2	addition	addition	NN
cord-006229-7yoilsho	887	3	,	,	,
cord-006229-7yoilsho	887	4	we	-PRON-	PRP
cord-006229-7yoilsho	887	5	found	find	VBD
cord-006229-7yoilsho	887	6	that	that	DT
cord-006229-7yoilsho	887	7	inhibition	inhibition	NN
cord-006229-7yoilsho	887	8	of	of	IN
cord-006229-7yoilsho	887	9	caspases	caspase	NNS
cord-006229-7yoilsho	887	10	by	by	IN
cord-006229-7yoilsho	887	11	the	the	DT
cord-006229-7yoilsho	887	12	broad	broad	JJ
cord-006229-7yoilsho	887	13	spectrum	spectrum	NN
cord-006229-7yoilsho	887	14	caspase	caspase	NN
cord-006229-7yoilsho	887	15	inhibitor	inhibitor	NN
cord-006229-7yoilsho	888	1	QVD	QVD	NNP
cord-006229-7yoilsho	888	2	significantly	significantly	RB
cord-006229-7yoilsho	888	3	ameliorated	ameliorate	VBD
cord-006229-7yoilsho	888	4	alpha	alpha	NN
cord-006229-7yoilsho	888	5	synuclein	synuclein	NN
cord-006229-7yoilsho	888	6	-	-	HYPH
cord-006229-7yoilsho	888	7	induced	induce	VBN
cord-006229-7yoilsho	888	8	dopaminergic	dopaminergic	JJ
cord-006229-7yoilsho	888	9	neuronal	neuronal	JJ
cord-006229-7yoilsho	888	10	death	death	NN
cord-006229-7yoilsho	888	11	.	.	.
cord-006229-7yoilsho	889	1	Interestingly	interestingly	RB
cord-006229-7yoilsho	889	2	,	,	,
cord-006229-7yoilsho	889	3	inhibition	inhibition	NN
cord-006229-7yoilsho	889	4	of	of	IN
cord-006229-7yoilsho	889	5	caspases	caspase	NNS
cord-006229-7yoilsho	889	6	preserved	preserve	VBN
cord-006229-7yoilsho	889	7	neuronal	neuronal	JJ
cord-006229-7yoilsho	889	8	network	network	NN
cord-006229-7yoilsho	889	9	integrity	integrity	NN
cord-006229-7yoilsho	889	10	,	,	,
cord-006229-7yoilsho	889	11	ATP	ATP	NNP
cord-006229-7yoilsho	889	12	levels	level	NNS
cord-006229-7yoilsho	889	13	and	and	CC
cord-006229-7yoilsho	889	14	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	889	15	respiration	respiration	NN
cord-006229-7yoilsho	889	16	capacity	capacity	NN
cord-006229-7yoilsho	889	17	in	in	IN
cord-006229-7yoilsho	889	18	both	both	DT
cord-006229-7yoilsho	889	19	paradigms	paradigm	NNS
cord-006229-7yoilsho	889	20	of	of	IN
cord-006229-7yoilsho	889	21	cytosolic	cytosolic	JJ
cord-006229-7yoilsho	889	22	and	and	CC
cord-006229-7yoilsho	889	23	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	889	24	alpha	alpha	NN
cord-006229-7yoilsho	889	25	synuclein	synuclein	NNP
cord-006229-7yoilsho	889	26	overexpression	overexpression	NN
cord-006229-7yoilsho	889	27	.	.	.
cord-006229-7yoilsho	890	1	Overall	overall	RB
cord-006229-7yoilsho	890	2	,	,	,
cord-006229-7yoilsho	890	3	our	-PRON-	PRP$
cord-006229-7yoilsho	890	4	findings	finding	NNS
cord-006229-7yoilsho	890	5	show	show	VBP
cord-006229-7yoilsho	890	6	that	that	IN
cord-006229-7yoilsho	890	7	cytosolic	cytosolic	JJ
cord-006229-7yoilsho	890	8	as	as	RB
cord-006229-7yoilsho	890	9	well	well	RB
cord-006229-7yoilsho	890	10	as	as	IN
cord-006229-7yoilsho	890	11	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	890	12	targeted	target	VBN
cord-006229-7yoilsho	890	13	expression	expression	NN
cord-006229-7yoilsho	890	14	of	of	IN
cord-006229-7yoilsho	890	15	alpha	alpha	NNP
cord-006229-7yoilsho	890	16	synuclein	synuclein	NNP
cord-006229-7yoilsho	890	17	is	be	VBZ
cord-006229-7yoilsho	890	18	detrimental	detrimental	JJ
cord-006229-7yoilsho	890	19	to	to	IN
cord-006229-7yoilsho	890	20	human	human	JJ
cord-006229-7yoilsho	890	21	dopaminergic	dopaminergic	JJ
cord-006229-7yoilsho	890	22	neurons	neuron	NNS
cord-006229-7yoilsho	890	23	,	,	,
cord-006229-7yoilsho	890	24	while	while	IN
cord-006229-7yoilsho	890	25	inhibition	inhibition	NN
cord-006229-7yoilsho	890	26	of	of	IN
cord-006229-7yoilsho	890	27	caspases	caspase	NNS
cord-006229-7yoilsho	890	28	amend	amend	VB
cord-006229-7yoilsho	890	29	alpha	alpha	NNP
cord-006229-7yoilsho	890	30	synuclein	synuclein	NNP
cord-006229-7yoilsho	890	31	toxicity	toxicity	NN
cord-006229-7yoilsho	890	32	at	at	IN
cord-006229-7yoilsho	890	33	the	the	DT
cord-006229-7yoilsho	890	34	level	level	NN
cord-006229-7yoilsho	890	35	of	of	IN
cord-006229-7yoilsho	890	36	mitochondria	mitochondrion	NNS
cord-006229-7yoilsho	890	37	.	.	.
cord-006229-7yoilsho	891	1	Thus	thus	RB
cord-006229-7yoilsho	891	2	,	,	,
cord-006229-7yoilsho	891	3	caspase	caspase	NN
cord-006229-7yoilsho	891	4	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	891	5	provide	provide	VBP
cord-006229-7yoilsho	891	6	promising	promising	JJ
cord-006229-7yoilsho	891	7	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	891	8	potential	potential	NN
cord-006229-7yoilsho	891	9	to	to	TO
cord-006229-7yoilsho	891	10	prevent	prevent	VB
cord-006229-7yoilsho	891	11	dopaminergic	dopaminergic	JJ
cord-006229-7yoilsho	891	12	neuronal	neuronal	JJ
cord-006229-7yoilsho	891	13	death	death	NN
cord-006229-7yoilsho	891	14	in	in	IN
cord-006229-7yoilsho	891	15	Parkinson	Parkinson	NNP
cord-006229-7yoilsho	891	16	's	's	POS
cord-006229-7yoilsho	891	17	syndromes	syndrome	NNS
cord-006229-7yoilsho	891	18	that	that	WDT
cord-006229-7yoilsho	891	19	are	be	VBP
cord-006229-7yoilsho	891	20	associated	associate	VBN
cord-006229-7yoilsho	891	21	with	with	IN
cord-006229-7yoilsho	891	22	alpha	alpha	NN
cord-006229-7yoilsho	891	23	synuclein	synuclein	NN
cord-006229-7yoilsho	891	24	toxicity	toxicity	NN
cord-006229-7yoilsho	891	25	.	.	.
cord-006229-7yoilsho	892	1	Degradation	degradation	NN
cord-006229-7yoilsho	892	2	of	of	IN
cord-006229-7yoilsho	892	3	and	and	CC
cord-006229-7yoilsho	892	4	adverse	adverse	JJ
cord-006229-7yoilsho	892	5	effects	effect	NNS
cord-006229-7yoilsho	892	6	caused	cause	VBN
cord-006229-7yoilsho	892	7	by	by	IN
cord-006229-7yoilsho	892	8	tattoo	tattoo	NN
cord-006229-7yoilsho	892	9	and	and	CC
cord-006229-7yoilsho	892	10	permanent	permanent	JJ
cord-006229-7yoilsho	892	11	make	make	VB
cord-006229-7yoilsho	892	12	-	-	HYPH
cord-006229-7yoilsho	892	13	up	up	RP
cord-006229-7yoilsho	892	14	pigments	pigment	NNS
cord-006229-7yoilsho	892	15	upon	upon	IN
cord-006229-7yoilsho	892	16	sunlight	sunlight	NN
cord-006229-7yoilsho	892	17	exposure	exposure	NN
cord-006229-7yoilsho	892	18	and	and	CC
cord-006229-7yoilsho	892	19	laser	laser	NN
cord-006229-7yoilsho	892	20	removal	removal	NN
cord-006229-7yoilsho	892	21	have	have	VBP
cord-006229-7yoilsho	892	22	been	be	VBN
cord-006229-7yoilsho	892	23	occasionally	occasionally	RB
cord-006229-7yoilsho	892	24	reported	report	VBN
cord-006229-7yoilsho	892	25	in	in	IN
cord-006229-7yoilsho	892	26	the	the	DT
cord-006229-7yoilsho	892	27	last	last	JJ
cord-006229-7yoilsho	892	28	decades	decade	NNS
cord-006229-7yoilsho	892	29	.	.	.
cord-006229-7yoilsho	893	1	Until	until	IN
cord-006229-7yoilsho	893	2	now	now	RB
cord-006229-7yoilsho	893	3	,	,	,
cord-006229-7yoilsho	893	4	only	only	RB
cord-006229-7yoilsho	893	5	the	the	DT
cord-006229-7yoilsho	893	6	ban	ban	NN
cord-006229-7yoilsho	893	7	of	of	IN
cord-006229-7yoilsho	893	8	certain	certain	JJ
cord-006229-7yoilsho	893	9	azo	azo	NNS
cord-006229-7yoilsho	893	10	-	-	HYPH
cord-006229-7yoilsho	893	11	pigments	pigment	NNS
cord-006229-7yoilsho	893	12	has	have	VBZ
cord-006229-7yoilsho	893	13	been	be	VBN
cord-006229-7yoilsho	893	14	addressed	address	VBN
cord-006229-7yoilsho	893	15	in	in	IN
cord-006229-7yoilsho	893	16	the	the	DT
cord-006229-7yoilsho	893	17	national	national	JJ
cord-006229-7yoilsho	893	18	legislation	legislation	NN
cord-006229-7yoilsho	893	19	.	.	.
cord-006229-7yoilsho	894	1	The	the	DT
cord-006229-7yoilsho	894	2	regulation	regulation	NN
cord-006229-7yoilsho	894	3	was	be	VBD
cord-006229-7yoilsho	894	4	based	base	VBN
cord-006229-7yoilsho	894	5	on	on	IN
cord-006229-7yoilsho	894	6	a	a	DT
cord-006229-7yoilsho	894	7	number	number	NN
cord-006229-7yoilsho	894	8	of	of	IN
cord-006229-7yoilsho	894	9	studies	study	NNS
cord-006229-7yoilsho	894	10	showing	show	VBG
cord-006229-7yoilsho	894	11	the	the	DT
cord-006229-7yoilsho	894	12	cleavage	cleavage	NN
cord-006229-7yoilsho	894	13	of	of	IN
cord-006229-7yoilsho	894	14	azo	azo	NN
cord-006229-7yoilsho	894	15	-	-	HYPH
cord-006229-7yoilsho	894	16	bonds	bond	NNS
cord-006229-7yoilsho	894	17	by	by	IN
cord-006229-7yoilsho	894	18	ultra	ultra	JJ
cord-006229-7yoilsho	894	19	violet	violet	JJ
cord-006229-7yoilsho	894	20	light	light	NN
cord-006229-7yoilsho	894	21	and	and	CC
cord-006229-7yoilsho	894	22	laser	laser	NN
cord-006229-7yoilsho	894	23	-	-	HYPH
cord-006229-7yoilsho	894	24	irradiation	irradiation	NN
cord-006229-7yoilsho	894	25	leading	lead	VBG
cord-006229-7yoilsho	894	26	to	to	IN
cord-006229-7yoilsho	894	27	the	the	DT
cord-006229-7yoilsho	894	28	formation	formation	NN
cord-006229-7yoilsho	894	29	of	of	IN
cord-006229-7yoilsho	894	30	carcinogenic	carcinogenic	JJ
cord-006229-7yoilsho	894	31	aromatic	aromatic	JJ
cord-006229-7yoilsho	894	32	amines	amine	NNS
cord-006229-7yoilsho	894	33	.	.	.
cord-006229-7yoilsho	895	1	As	as	IN
cord-006229-7yoilsho	895	2	a	a	DT
cord-006229-7yoilsho	895	3	result	result	NN
cord-006229-7yoilsho	895	4	,	,	,
cord-006229-7yoilsho	895	5	especially	especially	RB
cord-006229-7yoilsho	895	6	German	german	JJ
cord-006229-7yoilsho	895	7	tattoo	tattoo	NN
cord-006229-7yoilsho	895	8	ink	ink	NN
cord-006229-7yoilsho	895	9	manufactures	manufacture	NNS
cord-006229-7yoilsho	895	10	switched	switch	VBD
cord-006229-7yoilsho	895	11	to	to	IN
cord-006229-7yoilsho	895	12	the	the	DT
cord-006229-7yoilsho	895	13	use	use	NN
cord-006229-7yoilsho	895	14	of	of	IN
cord-006229-7yoilsho	895	15	more	more	JJR
cord-006229-7yoilsho	895	16	light	light	JJ
cord-006229-7yoilsho	895	17	-	-	HYPH
cord-006229-7yoilsho	895	18	fast	fast	JJ
cord-006229-7yoilsho	895	19	polycyclic	polycyclic	NN
cord-006229-7yoilsho	895	20	pigments	pigment	NNS
cord-006229-7yoilsho	895	21	assuming	assume	VBG
cord-006229-7yoilsho	895	22	these	these	DT
cord-006229-7yoilsho	895	23	would	would	MD
cord-006229-7yoilsho	895	24	be	be	VB
cord-006229-7yoilsho	895	25	safer	safe	JJR
cord-006229-7yoilsho	895	26	for	for	IN
cord-006229-7yoilsho	895	27	this	this	DT
cord-006229-7yoilsho	895	28	kind	kind	NN
cord-006229-7yoilsho	895	29	of	of	IN
cord-006229-7yoilsho	895	30	application	application	NN
cord-006229-7yoilsho	895	31	when	when	WRB
cord-006229-7yoilsho	895	32	compared	compare	VBN
cord-006229-7yoilsho	895	33	to	to	IN
cord-006229-7yoilsho	895	34	azo	azo	NN
cord-006229-7yoilsho	895	35	-	-	HYPH
cord-006229-7yoilsho	895	36	pigments	pigment	NNS
cord-006229-7yoilsho	895	37	.	.	.
cord-006229-7yoilsho	896	1	To	to	TO
cord-006229-7yoilsho	896	2	assess	assess	VB
cord-006229-7yoilsho	896	3	the	the	DT
cord-006229-7yoilsho	896	4	potential	potential	JJ
cord-006229-7yoilsho	896	5	risks	risk	NNS
cord-006229-7yoilsho	896	6	of	of	IN
cord-006229-7yoilsho	896	7	polycyclic	polycyclic	JJ
cord-006229-7yoilsho	896	8	pigments	pigment	NNS
cord-006229-7yoilsho	896	9	in	in	IN
cord-006229-7yoilsho	896	10	terms	term	NNS
cord-006229-7yoilsho	896	11	of	of	IN
cord-006229-7yoilsho	896	12	decomposition	decomposition	NN
cord-006229-7yoilsho	896	13	in	in	IN
cord-006229-7yoilsho	896	14	the	the	DT
cord-006229-7yoilsho	896	15	skin	skin	NN
cord-006229-7yoilsho	896	16	,	,	,
cord-006229-7yoilsho	896	17	we	-PRON-	PRP
cord-006229-7yoilsho	896	18	compared	compare	VBD
cord-006229-7yoilsho	896	19	the	the	DT
cord-006229-7yoilsho	896	20	photochemical	photochemical	JJ
cord-006229-7yoilsho	896	21	cleavage	cleavage	NN
cord-006229-7yoilsho	896	22	of	of	IN
cord-006229-7yoilsho	896	23	the	the	DT
cord-006229-7yoilsho	896	24	widely	widely	RB
cord-006229-7yoilsho	896	25	used	use	VBN
cord-006229-7yoilsho	896	26	azo	azo	NN
cord-006229-7yoilsho	896	27	-	-	HYPH
cord-006229-7yoilsho	896	28	pigment	pigment	NN
cord-006229-7yoilsho	896	29	Orange	Orange	NNP
cord-006229-7yoilsho	896	30	13	13	CD
cord-006229-7yoilsho	896	31	and	and	CC
cord-006229-7yoilsho	896	32	the	the	DT
cord-006229-7yoilsho	896	33	polycyclic	polycyclic	JJ
cord-006229-7yoilsho	896	34	pigment	pigment	NN
cord-006229-7yoilsho	896	35	copper	copper	NN
cord-006229-7yoilsho	896	36	phthalocyanine	phthalocyanine	NN
cord-006229-7yoilsho	896	37	blue	blue	NNP
cord-006229-7yoilsho	896	38	.	.	.
cord-006229-7yoilsho	897	1	Main	main	JJ
cord-006229-7yoilsho	897	2	decomposition	decomposition	NN
cord-006229-7yoilsho	897	3	products	product	NNS
cord-006229-7yoilsho	897	4	are	be	VBP
cord-006229-7yoilsho	897	5	qualitatively	qualitatively	RB
cord-006229-7yoilsho	897	6	and	and	CC
cord-006229-7yoilsho	897	7	quantitatively	quantitatively	RB
cord-006229-7yoilsho	897	8	analyzed	analyze	VBN
cord-006229-7yoilsho	897	9	after	after	IN
cord-006229-7yoilsho	897	10	Q	q	NN
cord-006229-7yoilsho	897	11	-	-	HYPH
cord-006229-7yoilsho	897	12	switched	switch	VBN
cord-006229-7yoilsho	897	13	laser	laser	NN
cord-006229-7yoilsho	897	14	irradiation	irradiation	NN
cord-006229-7yoilsho	897	15	of	of	IN
cord-006229-7yoilsho	897	16	1	1	CD
cord-006229-7yoilsho	897	17	mg	mg	NNP
cord-006229-7yoilsho	897	18	/	/	SYM
cord-006229-7yoilsho	897	19	ml	ml	NN
cord-006229-7yoilsho	897	20	aqueous	aqueous	JJ
cord-006229-7yoilsho	897	21	suspensions	suspension	NNS
cord-006229-7yoilsho	897	22	and	and	CC
cord-006229-7yoilsho	897	23	tattooed	tattoo	VBN
cord-006229-7yoilsho	897	24	pig	pig	NN
cord-006229-7yoilsho	897	25	skin	skin	NN
cord-006229-7yoilsho	897	26	.	.	.
cord-006229-7yoilsho	898	1	Irradiated	irradiated	JJ
cord-006229-7yoilsho	898	2	specimen	specimen	NN
cord-006229-7yoilsho	898	3	were	be	VBD
cord-006229-7yoilsho	898	4	extracted	extract	VBN
cord-006229-7yoilsho	898	5	with	with	IN
cord-006229-7yoilsho	898	6	ethyl	ethyl	NN
cord-006229-7yoilsho	898	7	acetate	acetate	NN
cord-006229-7yoilsho	898	8	and	and	CC
cord-006229-7yoilsho	898	9	analyzed	analyze	VBD
cord-006229-7yoilsho	898	10	with	with	IN
cord-006229-7yoilsho	898	11	gas	gas	NN
cord-006229-7yoilsho	898	12	chromatography	chromatography	NN
cord-006229-7yoilsho	898	13	coupled	couple	VBN
cord-006229-7yoilsho	898	14	to	to	IN
cord-006229-7yoilsho	898	15	mass	mass	JJ
cord-006229-7yoilsho	898	16	spectrometric	spectrometric	JJ
cord-006229-7yoilsho	898	17	detection	detection	NN
cord-006229-7yoilsho	898	18	(	(	-LRB-
cord-006229-7yoilsho	898	19	GC	GC	NNP
cord-006229-7yoilsho	898	20	/	/	SYM
cord-006229-7yoilsho	898	21	MS	MS	NNP
cord-006229-7yoilsho	898	22	)	)	-RRB-
cord-006229-7yoilsho	898	23	using	use	VBG
cord-006229-7yoilsho	898	24	liquid	liquid	JJ
cord-006229-7yoilsho	898	25	injection	injection	NN
cord-006229-7yoilsho	898	26	and	and	CC
cord-006229-7yoilsho	898	27	head	head	NN
cord-006229-7yoilsho	898	28	-	-	HYPH
cord-006229-7yoilsho	898	29	space	space	NN
cord-006229-7yoilsho	898	30	sampling	sampling	NN
cord-006229-7yoilsho	898	31	techniques	technique	NNS
cord-006229-7yoilsho	898	32	.	.	.
cord-006229-7yoilsho	899	1	We	-PRON-	PRP
cord-006229-7yoilsho	899	2	were	be	VBD
cord-006229-7yoilsho	899	3	able	able	JJ
cord-006229-7yoilsho	899	4	to	to	TO
cord-006229-7yoilsho	899	5	confirm	confirm	VB
cord-006229-7yoilsho	899	6	the	the	DT
cord-006229-7yoilsho	899	7	cleavage	cleavage	NN
cord-006229-7yoilsho	899	8	of	of	IN
cord-006229-7yoilsho	899	9	pigment	pigment	NN
cord-006229-7yoilsho	899	10	Orange	Orange	NNP
cord-006229-7yoilsho	899	11	13	13	CD
cord-006229-7yoilsho	899	12	at	at	IN
cord-006229-7yoilsho	899	13	the	the	DT
cord-006229-7yoilsho	899	14	azo	azo	NN
cord-006229-7yoilsho	899	15	-	-	HYPH
cord-006229-7yoilsho	899	16	and	and	CC
cord-006229-7yoilsho	899	17	other	other	JJ
cord-006229-7yoilsho	899	18	weak	weak	JJ
cord-006229-7yoilsho	899	19	bonds	bond	NNS
cord-006229-7yoilsho	899	20	in	in	IN
cord-006229-7yoilsho	899	21	our	-PRON-	PRP$
cord-006229-7yoilsho	899	22	experimental	experimental	JJ
cord-006229-7yoilsho	899	23	set	set	NN
cord-006229-7yoilsho	899	24	-	-	HYPH
cord-006229-7yoilsho	899	25	up	up	NN
cord-006229-7yoilsho	899	26	(	(	-LRB-
cord-006229-7yoilsho	899	27	Fig.1a	Fig.1a	NNP
cord-006229-7yoilsho	899	28	)	)	-RRB-
cord-006229-7yoilsho	899	29	.	.	.
cord-006229-7yoilsho	900	1	Amongst	amongst	IN
cord-006229-7yoilsho	900	2	other	other	JJ
cord-006229-7yoilsho	900	3	substances	substance	NNS
cord-006229-7yoilsho	900	4	,	,	,
cord-006229-7yoilsho	900	5	the	the	DT
cord-006229-7yoilsho	900	6	carcinogens	carcinogen	NNS
cord-006229-7yoilsho	900	7	aniline	aniline	NN
cord-006229-7yoilsho	900	8	(	(	-LRB-
cord-006229-7yoilsho	900	9	max	max	NNP
cord-006229-7yoilsho	900	10	.	.	NNP
cord-006229-7yoilsho	900	11	conc	conc	NNP
cord-006229-7yoilsho	900	12	.	.	.
cord-006229-7yoilsho	901	1	1.01	1.01	CD
cord-006229-7yoilsho	901	2	±	±	CD
cord-006229-7yoilsho	901	3	0.12	0.12	CD
cord-006229-7yoilsho	902	1	µg	µg	NNP
cord-006229-7yoilsho	902	2	/	/	SYM
cord-006229-7yoilsho	902	3	mL	mL	NNP
cord-006229-7yoilsho	902	4	)	)	-RRB-
cord-006229-7yoilsho	902	5	and	and	CC
cord-006229-7yoilsho	902	6	3,3-dichlorobenzidine	3,3-dichlorobenzidine	CD
cord-006229-7yoilsho	902	7	(	(	-LRB-
cord-006229-7yoilsho	902	8	max	max	NNP
cord-006229-7yoilsho	902	9	.	.	NNP
cord-006229-7yoilsho	902	10	conc	conc	NNP
cord-006229-7yoilsho	902	11	.	.	.
cord-006229-7yoilsho	903	1	0.88	0.88	CD
cord-006229-7yoilsho	903	2	±	±	CD
cord-006229-7yoilsho	903	3	0.18	0.18	CD
cord-006229-7yoilsho	903	4	µg	µg	NN
cord-006229-7yoilsho	903	5	/	/	SYM
cord-006229-7yoilsho	903	6	mL	mL	NNP
cord-006229-7yoilsho	903	7	)	)	-RRB-
cord-006229-7yoilsho	903	8	are	be	VBP
cord-006229-7yoilsho	903	9	formed	form	VBN
cord-006229-7yoilsho	903	10	.	.	.
cord-006229-7yoilsho	904	1	Despite	despite	IN
cord-006229-7yoilsho	904	2	the	the	DT
cord-006229-7yoilsho	904	3	lack	lack	NN
cord-006229-7yoilsho	904	4	of	of	IN
cord-006229-7yoilsho	904	5	such	such	JJ
cord-006229-7yoilsho	904	6	weak	weak	JJ
cord-006229-7yoilsho	904	7	bonds	bond	NNS
cord-006229-7yoilsho	904	8	,	,	,
cord-006229-7yoilsho	904	9	the	the	DT
cord-006229-7yoilsho	904	10	highly	highly	RB
cord-006229-7yoilsho	904	11	stable	stable	JJ
cord-006229-7yoilsho	904	12	porphyrin	porphyrin	NN
cord-006229-7yoilsho	904	13	-	-	HYPH
cord-006229-7yoilsho	904	14	like	like	JJ
cord-006229-7yoilsho	904	15	structure	structure	NN
cord-006229-7yoilsho	904	16	of	of	IN
cord-006229-7yoilsho	904	17	copper	copper	NN
cord-006229-7yoilsho	904	18	phthalocyanine	phthalocyanine	NN
cord-006229-7yoilsho	904	19	blue	blue	NNP
cord-006229-7yoilsho	904	20	is	be	VBZ
cord-006229-7yoilsho	904	21	as	as	RB
cord-006229-7yoilsho	904	22	well	well	RB
cord-006229-7yoilsho	904	23	decomposed	decompose	VBN
cord-006229-7yoilsho	904	24	upon	upon	IN
cord-006229-7yoilsho	904	25	laser	laser	NN
cord-006229-7yoilsho	904	26	-	-	HYPH
cord-006229-7yoilsho	904	27	irradiation	irradiation	NN
cord-006229-7yoilsho	904	28	(	(	-LRB-
cord-006229-7yoilsho	904	29	Fig	fig	NN
cord-006229-7yoilsho	904	30	.	.	.
cord-006229-7yoilsho	904	31	1b	1b	CD
cord-006229-7yoilsho	904	32	)	)	-RRB-
cord-006229-7yoilsho	904	33	.	.	.
cord-006229-7yoilsho	905	1	Here	here	RB
cord-006229-7yoilsho	905	2	,	,	,
cord-006229-7yoilsho	905	3	1,2-benzenedicarbonitrile	1,2-benzenedicarbonitrile	CD
cord-006229-7yoilsho	905	4	(	(	-LRB-
cord-006229-7yoilsho	905	5	max	max	NNP
cord-006229-7yoilsho	905	6	.	.	NNP
cord-006229-7yoilsho	905	7	conc	conc	NNP
cord-006229-7yoilsho	905	8	.	.	.
cord-006229-7yoilsho	906	1	1.11	1.11	CD
cord-006229-7yoilsho	906	2	±	±	CD
cord-006229-7yoilsho	906	3	0.12	0.12	CD
cord-006229-7yoilsho	907	1	µg	µg	NNP
cord-006229-7yoilsho	907	2	/	/	SYM
cord-006229-7yoilsho	907	3	mL	mL	NNP
cord-006229-7yoilsho	907	4	)	)	-RRB-
cord-006229-7yoilsho	907	5	were	be	VBD
cord-006229-7yoilsho	907	6	found	find	VBN
cord-006229-7yoilsho	907	7	as	as	IN
cord-006229-7yoilsho	907	8	the	the	DT
cord-006229-7yoilsho	907	9	main	main	JJ
cord-006229-7yoilsho	907	10	decomposition	decomposition	NN
cord-006229-7yoilsho	907	11	product	product	NN
cord-006229-7yoilsho	907	12	in	in	IN
cord-006229-7yoilsho	907	13	all	all	DT
cord-006229-7yoilsho	907	14	experimental	experimental	JJ
cord-006229-7yoilsho	907	15	setups	setup	NNS
cord-006229-7yoilsho	907	16	.	.	.
cord-006229-7yoilsho	908	1	Concentrations	concentration	NNS
cord-006229-7yoilsho	908	2	of	of	IN
cord-006229-7yoilsho	908	3	cleavage	cleavage	NN
cord-006229-7yoilsho	908	4	products	product	NNS
cord-006229-7yoilsho	908	5	were	be	VBD
cord-006229-7yoilsho	908	6	generally	generally	RB
cord-006229-7yoilsho	908	7	higher	high	JJR
cord-006229-7yoilsho	908	8	in	in	IN
cord-006229-7yoilsho	908	9	aqueous	aqueous	JJ
cord-006229-7yoilsho	908	10	suspensions	suspension	NNS
cord-006229-7yoilsho	908	11	compared	compare	VBN
cord-006229-7yoilsho	908	12	to	to	IN
cord-006229-7yoilsho	908	13	pig	pig	NN
cord-006229-7yoilsho	908	14	skin	skin	NN
cord-006229-7yoilsho	908	15	extracts	extract	NNS
cord-006229-7yoilsho	908	16	with	with	IN
cord-006229-7yoilsho	908	17	both	both	DT
cord-006229-7yoilsho	908	18	pigments	pigment	NNS
cord-006229-7yoilsho	908	19	.	.	.
cord-006229-7yoilsho	909	1	Additionally	additionally	RB
cord-006229-7yoilsho	909	2	,	,	,
cord-006229-7yoilsho	909	3	the	the	DT
cord-006229-7yoilsho	909	4	highly	highly	RB
cord-006229-7yoilsho	909	5	toxic	toxic	JJ
cord-006229-7yoilsho	909	6	gas	gas	NN
cord-006229-7yoilsho	909	7	hydrogen	hydrogen	NN
cord-006229-7yoilsho	909	8	cyanide	cyanide	NN
cord-006229-7yoilsho	909	9	(	(	-LRB-
cord-006229-7yoilsho	909	10	max	max	NNP
cord-006229-7yoilsho	909	11	.	.	NNP
cord-006229-7yoilsho	909	12	conc	conc	NNP
cord-006229-7yoilsho	909	13	.	.	.
cord-006229-7yoilsho	910	1	35.8	35.8	CD
cord-006229-7yoilsho	910	2	±	±	CD
cord-006229-7yoilsho	910	3	4.32	4.32	CD
cord-006229-7yoilsho	910	4	µg	µg	NN
cord-006229-7yoilsho	910	5	/	/	SYM
cord-006229-7yoilsho	910	6	mL	mL	NNP
cord-006229-7yoilsho	910	7	)	)	-RRB-
cord-006229-7yoilsho	910	8	and	and	CC
cord-006229-7yoilsho	910	9	the	the	DT
cord-006229-7yoilsho	910	10	human	human	JJ
cord-006229-7yoilsho	910	11	carcinogen	carcinogen	NN
cord-006229-7yoilsho	910	12	benzene	benzene	NN
cord-006229-7yoilsho	910	13	(	(	-LRB-
cord-006229-7yoilsho	910	14	max	max	NNP
cord-006229-7yoilsho	910	15	.	.	NNP
cord-006229-7yoilsho	910	16	conc	conc	NNP
cord-006229-7yoilsho	910	17	.	.	.
cord-006229-7yoilsho	910	18	0.19	0.19	CD
cord-006229-7yoilsho	910	19	±	±	XX
cord-006229-7yoilsho	911	1	0.06	0.06	CD
cord-006229-7yoilsho	911	2	µg	µg	NNP
cord-006229-7yoilsho	911	3	/	/	SYM
cord-006229-7yoilsho	911	4	mL	mL	NNP
cord-006229-7yoilsho	911	5	)	)	-RRB-
cord-006229-7yoilsho	911	6	were	be	VBD
cord-006229-7yoilsho	911	7	formed	form	VBN
cord-006229-7yoilsho	911	8	from	from	IN
cord-006229-7yoilsho	911	9	both	both	DT
cord-006229-7yoilsho	911	10	pigments	pigment	NNS
cord-006229-7yoilsho	911	11	,	,	,
cord-006229-7yoilsho	911	12	dependent	dependent	JJ
cord-006229-7yoilsho	911	13	on	on	IN
cord-006229-7yoilsho	911	14	the	the	DT
cord-006229-7yoilsho	911	15	laser	laser	NN
cord-006229-7yoilsho	911	16	wavelengths	wavelength	NNS
cord-006229-7yoilsho	911	17	used	use	VBN
cord-006229-7yoilsho	911	18	.	.	.
cord-006229-7yoilsho	912	1	Cyanide	cyanide	NN
cord-006229-7yoilsho	912	2	levels	level	NNS
cord-006229-7yoilsho	912	3	of	of	IN
cord-006229-7yoilsho	912	4	≥50	≥50	DT
cord-006229-7yoilsho	912	5	µg	µg	NN
cord-006229-7yoilsho	912	6	/	/	SYM
cord-006229-7yoilsho	912	7	mL	ml	NN
cord-006229-7yoilsho	912	8	evolving	evolve	VBG
cord-006229-7yoilsho	912	9	upon	upon	IN
cord-006229-7yoilsho	912	10	ruby	ruby	NN
cord-006229-7yoilsho	912	11	laser	laser	NN
cord-006229-7yoilsho	912	12	irradiation	irradiation	NN
cord-006229-7yoilsho	912	13	of	of	IN
cord-006229-7yoilsho	912	14	>	>	XX
cord-006229-7yoilsho	913	1	1.5	1.5	CD
cord-006229-7yoilsho	913	2	mg	mg	NNP
cord-006229-7yoilsho	913	3	/	/	SYM
cord-006229-7yoilsho	913	4	ml	ml	NN
cord-006229-7yoilsho	913	5	aqueous	aqueous	JJ
cord-006229-7yoilsho	913	6	suspensions	suspension	NNS
cord-006229-7yoilsho	913	7	of	of	IN
cord-006229-7yoilsho	913	8	phthalocyanine	phthalocyanine	NN
cord-006229-7yoilsho	913	9	blue	blue	NNP
cord-006229-7yoilsho	913	10	were	be	VBD
cord-006229-7yoilsho	913	11	proven	prove	VBN
cord-006229-7yoilsho	913	12	to	to	TO
cord-006229-7yoilsho	913	13	significantly	significantly	RB
cord-006229-7yoilsho	913	14	reduce	reduce	VB
cord-006229-7yoilsho	913	15	cell	cell	NN
cord-006229-7yoilsho	913	16	viability	viability	NN
cord-006229-7yoilsho	913	17	in	in	IN
cord-006229-7yoilsho	913	18	human	human	JJ
cord-006229-7yoilsho	913	19	skin	skin	NN
cord-006229-7yoilsho	913	20	cells	cell	NNS
cord-006229-7yoilsho	913	21	in	in	IN
cord-006229-7yoilsho	913	22	vitro	vitro	FW
cord-006229-7yoilsho	913	23	.	.	.
cord-006229-7yoilsho	914	1	Reference	reference	NN
cord-006229-7yoilsho	914	2	1	1	CD
cord-006229-7yoilsho	914	3	Schreiver	Schreiver	NNP
cord-006229-7yoilsho	914	4	,	,	,
cord-006229-7yoilsho	914	5	I.	I.	NNP
cord-006229-7yoilsho	914	6	,	,	,
cord-006229-7yoilsho	914	7	Hutzler	Hutzler	NNP
cord-006229-7yoilsho	914	8	,	,	,
cord-006229-7yoilsho	914	9	C.	C.	NNP
cord-006229-7yoilsho	914	10	,	,	,
cord-006229-7yoilsho	914	11	Laux	Laux	NNP
cord-006229-7yoilsho	914	12	,	,	,
cord-006229-7yoilsho	914	13	P.	P.	NNP
cord-006229-7yoilsho	914	14	,	,	,
cord-006229-7yoilsho	914	15	Berlien	Berlien	NNP
cord-006229-7yoilsho	914	16	,	,	,
cord-006229-7yoilsho	914	17	H.	H.	NNP
cord-006229-7yoilsho	914	18	P.	P.	NNP
cord-006229-7yoilsho	914	19	&	&	CC
cord-006229-7yoilsho	914	20	Luch	Luch	NNP
cord-006229-7yoilsho	914	21	,	,	,
cord-006229-7yoilsho	914	22	A.	A.	NNP
cord-006229-7yoilsho	914	23	Formation	formation	NN
cord-006229-7yoilsho	914	24	of	of	IN
cord-006229-7yoilsho	914	25	highly	highly	RB
cord-006229-7yoilsho	914	26	toxic	toxic	JJ
cord-006229-7yoilsho	914	27	hydrogen	hydrogen	NN
cord-006229-7yoilsho	914	28	cyanide	cyanide	NN
cord-006229-7yoilsho	914	29	upon	upon	IN
cord-006229-7yoilsho	914	30	ruby	ruby	NN
cord-006229-7yoilsho	914	31	laser	laser	NN
cord-006229-7yoilsho	914	32	irradiation	irradiation	NN
cord-006229-7yoilsho	914	33	of	of	IN
cord-006229-7yoilsho	914	34	the	the	DT
cord-006229-7yoilsho	914	35	tattoo	tattoo	NN
cord-006229-7yoilsho	914	36	pigment	pigment	NN
cord-006229-7yoilsho	914	37	phthalocyanine	phthalocyanine	NN
cord-006229-7yoilsho	914	38	blue	blue	NN
cord-006229-7yoilsho	914	39	.	.	.
cord-006229-7yoilsho	915	1	Sci	Sci	NNP
cord-006229-7yoilsho	915	2	Rep	Rep	NNP
cord-006229-7yoilsho	915	3	5	5	CD
cord-006229-7yoilsho	915	4	,	,	,
cord-006229-7yoilsho	915	5	12915	12915	CD
cord-006229-7yoilsho	915	6	(	(	-LRB-
cord-006229-7yoilsho	915	7	2015	2015	CD
cord-006229-7yoilsho	915	8	)	)	-RRB-
cord-006229-7yoilsho	915	9	.	.	.
cord-006229-7yoilsho	916	1	Understanding	understand	VBG
cord-006229-7yoilsho	916	2	the	the	DT
cord-006229-7yoilsho	916	3	interactions	interaction	NNS
cord-006229-7yoilsho	916	4	between	between	IN
cord-006229-7yoilsho	916	5	nanoscaled	nanoscaled	JJ
cord-006229-7yoilsho	916	6	objects	object	NNS
cord-006229-7yoilsho	916	7	and	and	CC
cord-006229-7yoilsho	916	8	living	living	NN
cord-006229-7yoilsho	916	9	cells	cell	NNS
cord-006229-7yoilsho	916	10	is	be	VBZ
cord-006229-7yoilsho	916	11	of	of	IN
cord-006229-7yoilsho	916	12	great	great	JJ
cord-006229-7yoilsho	916	13	importance	importance	NN
cord-006229-7yoilsho	916	14	for	for	IN
cord-006229-7yoilsho	916	15	risk	risk	NN
cord-006229-7yoilsho	916	16	assessment	assessment	NN
cord-006229-7yoilsho	916	17	,	,	,
cord-006229-7yoilsho	916	18	due	due	IN
cord-006229-7yoilsho	916	19	to	to	IN
cord-006229-7yoilsho	916	20	rising	rise	VBG
cord-006229-7yoilsho	916	21	application	application	NN
cord-006229-7yoilsho	916	22	of	of	IN
cord-006229-7yoilsho	916	23	nanomaterials	nanomaterial	NNS
cord-006229-7yoilsho	916	24	in	in	IN
cord-006229-7yoilsho	916	25	foodrelated	foodrelated	JJ
cord-006229-7yoilsho	916	26	products	product	NNS
cord-006229-7yoilsho	916	27	.	.	.
cord-006229-7yoilsho	917	1	Several	several	JJ
cord-006229-7yoilsho	917	2	studies	study	NNS
cord-006229-7yoilsho	917	3	show	show	VBP
cord-006229-7yoilsho	917	4	that	that	IN
cord-006229-7yoilsho	917	5	silver	silver	NN
cord-006229-7yoilsho	917	6	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	917	7	can	can	MD
cord-006229-7yoilsho	917	8	reach	reach	VB
cord-006229-7yoilsho	917	9	the	the	DT
cord-006229-7yoilsho	917	10	intestinal	intestinal	JJ
cord-006229-7yoilsho	917	11	epithelia	epithelium	NNS
cord-006229-7yoilsho	917	12	in	in	IN
cord-006229-7yoilsho	917	13	nanoform	nanoform	NNP
cord-006229-7yoilsho	917	14	in	in	IN
cord-006229-7yoilsho	917	15	a	a	DT
cord-006229-7yoilsho	917	16	human	human	NN
cord-006229-7yoilsho	917	17	in	in	IN
cord-006229-7yoilsho	917	18	vitro	vitro	FW
cord-006229-7yoilsho	917	19	digestion	digestion	NN
cord-006229-7yoilsho	917	20	model	model	NN
cord-006229-7yoilsho	917	21	.	.	.
cord-006229-7yoilsho	918	1	Nevertheless	nevertheless	RB
cord-006229-7yoilsho	918	2	,	,	,
cord-006229-7yoilsho	918	3	only	only	RB
cord-006229-7yoilsho	918	4	sparse	sparse	JJ
cord-006229-7yoilsho	918	5	data	datum	NNS
cord-006229-7yoilsho	918	6	concerning	concern	VBG
cord-006229-7yoilsho	918	7	the	the	DT
cord-006229-7yoilsho	918	8	direct	direct	JJ
cord-006229-7yoilsho	918	9	quantification	quantification	NN
cord-006229-7yoilsho	918	10	of	of	IN
cord-006229-7yoilsho	918	11	cellular	cellular	JJ
cord-006229-7yoilsho	918	12	uptake	uptake	NN
cord-006229-7yoilsho	918	13	of	of	IN
cord-006229-7yoilsho	918	14	silver	silver	NN
cord-006229-7yoilsho	918	15	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	918	16	are	be	VBP
cord-006229-7yoilsho	918	17	available	available	JJ
cord-006229-7yoilsho	918	18	.	.	.
cord-006229-7yoilsho	919	1	Therefore	therefore	RB
cord-006229-7yoilsho	919	2	,	,	,
cord-006229-7yoilsho	919	3	this	this	DT
cord-006229-7yoilsho	919	4	study	study	NN
cord-006229-7yoilsho	919	5	was	be	VBD
cord-006229-7yoilsho	919	6	focused	focus	VBN
cord-006229-7yoilsho	919	7	on	on	IN
cord-006229-7yoilsho	919	8	a	a	DT
cord-006229-7yoilsho	919	9	systematical	systematical	JJ
cord-006229-7yoilsho	919	10	quantitative	quantitative	JJ
cord-006229-7yoilsho	919	11	comparison	comparison	NN
cord-006229-7yoilsho	919	12	of	of	IN
cord-006229-7yoilsho	919	13	the	the	DT
cord-006229-7yoilsho	919	14	cellular	cellular	JJ
cord-006229-7yoilsho	919	15	uptake	uptake	NN
cord-006229-7yoilsho	919	16	of	of	IN
cord-006229-7yoilsho	919	17	differently	differently	RB
cord-006229-7yoilsho	919	18	coated	coat	VBN
cord-006229-7yoilsho	919	19	silver	silver	NN
cord-006229-7yoilsho	919	20	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	919	21	of	of	IN
cord-006229-7yoilsho	919	22	comparable	comparable	JJ
cord-006229-7yoilsho	919	23	size	size	NN
cord-006229-7yoilsho	919	24	.	.	.
cord-006229-7yoilsho	920	1	Intracellular	Intracellular	NNP
cord-006229-7yoilsho	920	2	uptake	uptake	NN
cord-006229-7yoilsho	920	3	was	be	VBD
cord-006229-7yoilsho	920	4	determined	determine	VBN
cord-006229-7yoilsho	920	5	quantitatively	quantitatively	RB
cord-006229-7yoilsho	920	6	via	via	IN
cord-006229-7yoilsho	920	7	a	a	DT
cord-006229-7yoilsho	920	8	Transwell	Transwell	NNP
cord-006229-7yoilsho	920	9	TM	TM	NNP
cord-006229-7yoilsho	920	10	-System	-system	NN
cord-006229-7yoilsho	920	11	with	with	IN
cord-006229-7yoilsho	920	12	subsequent	subsequent	JJ
cord-006229-7yoilsho	920	13	elemental	elemental	JJ
cord-006229-7yoilsho	920	14	analysis	analysis	NN
cord-006229-7yoilsho	920	15	(	(	-LRB-
cord-006229-7yoilsho	920	16	AAS	AAS	NNP
cord-006229-7yoilsho	920	17	)	)	-RRB-
cord-006229-7yoilsho	920	18	and	and	CC
cord-006229-7yoilsho	920	19	Ion	Ion	NNP
cord-006229-7yoilsho	920	20	Beam	Beam	NNP
cord-006229-7yoilsho	920	21	Microscopy	Microscopy	NNP
cord-006229-7yoilsho	920	22	(	(	-LRB-
cord-006229-7yoilsho	920	23	IBM	IBM	NNP
cord-006229-7yoilsho	920	24	)	)	-RRB-
cord-006229-7yoilsho	920	25	.	.	.
cord-006229-7yoilsho	921	1	Silver	silver	NN
cord-006229-7yoilsho	921	2	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	921	3	were	be	VBD
cord-006229-7yoilsho	921	4	coated	coat	VBN
cord-006229-7yoilsho	921	5	with	with	IN
cord-006229-7yoilsho	921	6	poly	poly	NNP
cord-006229-7yoilsho	921	7	(	(	-LRB-
cord-006229-7yoilsho	921	8	acrylic	acrylic	JJ
cord-006229-7yoilsho	921	9	acid	acid	NN
cord-006229-7yoilsho	921	10	)	)	-RRB-
cord-006229-7yoilsho	921	11	and	and	CC
cord-006229-7yoilsho	921	12	polyvinylpyrrolidone	polyvinylpyrrolidone	NNP
cord-006229-7yoilsho	921	13	and	and	CC
cord-006229-7yoilsho	921	14	characterized	characterize	VBN
cord-006229-7yoilsho	921	15	extensively	extensively	RB
cord-006229-7yoilsho	921	16	by	by	IN
cord-006229-7yoilsho	921	17	TEM	TEM	NNP
cord-006229-7yoilsho	921	18	,	,	,
cord-006229-7yoilsho	921	19	DLS	DLS	NNP
cord-006229-7yoilsho	921	20	,	,	,
cord-006229-7yoilsho	921	21	SAXS	SAXS	NNP
cord-006229-7yoilsho	921	22	,	,	,
cord-006229-7yoilsho	921	23	Zetasizer	Zetasizer	NNP
cord-006229-7yoilsho	921	24	and	and	CC
cord-006229-7yoilsho	921	25	NanoSight	NanoSight	NNP
cord-006229-7yoilsho	921	26	.	.	.
cord-006229-7yoilsho	922	1	AgPURE	AgPURE	NNP
cord-006229-7yoilsho	922	2	TM	TM	NNP
cord-006229-7yoilsho	922	3	as	as	IN
cord-006229-7yoilsho	922	4	a	a	DT
cord-006229-7yoilsho	922	5	widely	widely	RB
cord-006229-7yoilsho	922	6	used	use	VBN
cord-006229-7yoilsho	922	7	reference	reference	NN
cord-006229-7yoilsho	922	8	nanoparticle	nanoparticle	NN
cord-006229-7yoilsho	922	9	coated	coat	VBN
cord-006229-7yoilsho	922	10	with	with	IN
cord-006229-7yoilsho	922	11	Tween	Tween	NNP
cord-006229-7yoilsho	922	12	20	20	CD
cord-006229-7yoilsho	922	13	and	and	CC
cord-006229-7yoilsho	922	14	Tagat	Tagat	NNPS
cord-006229-7yoilsho	922	15	TO	to	IN
cord-006229-7yoilsho	922	16	V	V	NNP
cord-006229-7yoilsho	922	17	was	be	VBD
cord-006229-7yoilsho	922	18	also	also	RB
cord-006229-7yoilsho	922	19	used	use	VBN
cord-006229-7yoilsho	922	20	for	for	IN
cord-006229-7yoilsho	922	21	comparison	comparison	NN
cord-006229-7yoilsho	922	22	.	.	.
cord-006229-7yoilsho	923	1	Different	different	JJ
cord-006229-7yoilsho	923	2	intestinal	intestinal	JJ
cord-006229-7yoilsho	923	3	cell	cell	NN
cord-006229-7yoilsho	923	4	models	model	NNS
cord-006229-7yoilsho	923	5	were	be	VBD
cord-006229-7yoilsho	923	6	applied	apply	VBN
cord-006229-7yoilsho	923	7	to	to	TO
cord-006229-7yoilsho	923	8	get	get	VB
cord-006229-7yoilsho	923	9	closer	close	JJR
cord-006229-7yoilsho	923	10	to	to	IN
cord-006229-7yoilsho	923	11	the	the	DT
cord-006229-7yoilsho	923	12	complex	complex	NN
cord-006229-7yoilsho	923	13	in	in	IN
cord-006229-7yoilsho	923	14	vivo	vivo	NN
cord-006229-7yoilsho	923	15	situation	situation	NN
cord-006229-7yoilsho	923	16	:	:	:
cord-006229-7yoilsho	923	17	Beside	beside	IN
cord-006229-7yoilsho	923	18	the	the	DT
cord-006229-7yoilsho	923	19	widely	widely	RB
cord-006229-7yoilsho	923	20	used	use	VBN
cord-006229-7yoilsho	923	21	Caco-2	caco-2	NN
cord-006229-7yoilsho	923	22	model	model	NN
cord-006229-7yoilsho	923	23	we	-PRON-	PRP
cord-006229-7yoilsho	923	24	also	also	RB
cord-006229-7yoilsho	923	25	investigated	investigate	VBD
cord-006229-7yoilsho	923	26	particle	particle	NN
cord-006229-7yoilsho	923	27	uptake	uptake	NN
cord-006229-7yoilsho	923	28	in	in	IN
cord-006229-7yoilsho	923	29	a	a	DT
cord-006229-7yoilsho	923	30	model	model	NN
cord-006229-7yoilsho	923	31	which	which	WDT
cord-006229-7yoilsho	923	32	considered	consider	VBD
cord-006229-7yoilsho	923	33	the	the	DT
cord-006229-7yoilsho	923	34	enterocyte	enterocyte	NN
cord-006229-7yoilsho	923	35	-	-	HYPH
cord-006229-7yoilsho	923	36	covering	cover	VBG
cord-006229-7yoilsho	923	37	mucus	mucus	NN
cord-006229-7yoilsho	923	38	layer	layer	NN
cord-006229-7yoilsho	923	39	,	,	,
cord-006229-7yoilsho	923	40	as	as	RB
cord-006229-7yoilsho	923	41	well	well	RB
cord-006229-7yoilsho	923	42	as	as	IN
cord-006229-7yoilsho	923	43	in	in	IN
cord-006229-7yoilsho	923	44	a	a	DT
cord-006229-7yoilsho	923	45	model	model	NN
cord-006229-7yoilsho	923	46	specialized	specialize	VBN
cord-006229-7yoilsho	923	47	on	on	IN
cord-006229-7yoilsho	923	48	particle	particle	NN
cord-006229-7yoilsho	923	49	uptake	uptake	NN
cord-006229-7yoilsho	923	50	,	,	,
cord-006229-7yoilsho	923	51	the	the	DT
cord-006229-7yoilsho	923	52	so	so	RB
cord-006229-7yoilsho	923	53	-	-	HYPH
cord-006229-7yoilsho	923	54	called	call	VBN
cord-006229-7yoilsho	923	55	M	M	NNP
cord-006229-7yoilsho	923	56	-	-	HYPH
cord-006229-7yoilsho	923	57	cell	cell	NN
cord-006229-7yoilsho	923	58	model	model	NN
cord-006229-7yoilsho	923	59	.	.	.
cord-006229-7yoilsho	924	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	924	2	findings	finding	NNS
cord-006229-7yoilsho	924	3	suggest	suggest	VBP
cord-006229-7yoilsho	924	4	that	that	IN
cord-006229-7yoilsho	924	5	silver	silver	JJ
cord-006229-7yoilsho	924	6	uptake	uptake	NN
cord-006229-7yoilsho	924	7	is	be	VBZ
cord-006229-7yoilsho	924	8	clearly	clearly	RB
cord-006229-7yoilsho	924	9	a	a	DT
cord-006229-7yoilsho	924	10	particle	particle	NN
cord-006229-7yoilsho	924	11	-	-	:
cord-006229-7yoilsho	924	12	and	and	CC
cord-006229-7yoilsho	924	13	not	not	RB
cord-006229-7yoilsho	924	14	an	an	DT
cord-006229-7yoilsho	924	15	ion	ion	NN
cord-006229-7yoilsho	924	16	-	-	HYPH
cord-006229-7yoilsho	924	17	related	relate	VBN
cord-006229-7yoilsho	924	18	effect	effect	NN
cord-006229-7yoilsho	924	19	.	.	.
cord-006229-7yoilsho	925	1	The	the	DT
cord-006229-7yoilsho	925	2	internalization	internalization	NN
cord-006229-7yoilsho	925	3	of	of	IN
cord-006229-7yoilsho	925	4	silver	silver	NN
cord-006229-7yoilsho	925	5	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	925	6	was	be	VBD
cord-006229-7yoilsho	925	7	enhanced	enhance	VBN
cord-006229-7yoilsho	925	8	in	in	IN
cord-006229-7yoilsho	925	9	uptake	uptake	NN
cord-006229-7yoilsho	925	10	-	-	HYPH
cord-006229-7yoilsho	925	11	specialized	specialized	JJ
cord-006229-7yoilsho	925	12	M	M	NNP
cord-006229-7yoilsho	925	13	-	-	HYPH
cord-006229-7yoilsho	925	14	cells	cell	NNS
cord-006229-7yoilsho	925	15	,	,	,
cord-006229-7yoilsho	925	16	although	although	IN
cord-006229-7yoilsho	925	17	no	no	DT
cord-006229-7yoilsho	925	18	enhanced	enhance	VBN
cord-006229-7yoilsho	925	19	transport	transport	NN
cord-006229-7yoilsho	925	20	through	through	IN
cord-006229-7yoilsho	925	21	the	the	DT
cord-006229-7yoilsho	925	22	cells	cell	NNS
cord-006229-7yoilsho	925	23	was	be	VBD
cord-006229-7yoilsho	925	24	observable	observable	JJ
cord-006229-7yoilsho	925	25	.	.	.
cord-006229-7yoilsho	926	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	926	2	,	,	,
cord-006229-7yoilsho	926	3	the	the	DT
cord-006229-7yoilsho	926	4	mucus	mucus	NN
cord-006229-7yoilsho	926	5	did	do	VBD
cord-006229-7yoilsho	926	6	not	not	RB
cord-006229-7yoilsho	926	7	providing	provide	VBG
cord-006229-7yoilsho	926	8	a	a	DT
cord-006229-7yoilsho	926	9	substantial	substantial	JJ
cord-006229-7yoilsho	926	10	additional	additional	JJ
cord-006229-7yoilsho	926	11	barrier	barrier	NN
cord-006229-7yoilsho	926	12	for	for	IN
cord-006229-7yoilsho	926	13	nanoparticle	nanoparticle	NN
cord-006229-7yoilsho	926	14	internalization	internalization	NN
cord-006229-7yoilsho	926	15	.	.	.
cord-006229-7yoilsho	927	1	Rutherford	Rutherford	NNP
cord-006229-7yoilsho	927	2	Backscattering	Backscattering	NNP
cord-006229-7yoilsho	927	3	Spectrometry	Spectrometry	NNP
cord-006229-7yoilsho	927	4	(	(	-LRB-
cord-006229-7yoilsho	927	5	RBS	RBS	NNP
cord-006229-7yoilsho	927	6	)	)	-RRB-
cord-006229-7yoilsho	927	7	via	via	IN
cord-006229-7yoilsho	927	8	IBM	IBM	NNP
cord-006229-7yoilsho	927	9	allowed	allow	VBD
cord-006229-7yoilsho	927	10	distinguishing	distinguish	VBG
cord-006229-7yoilsho	927	11	between	between	IN
cord-006229-7yoilsho	927	12	adsorbed	adsorb	VBN
cord-006229-7yoilsho	927	13	an	an	DT
cord-006229-7yoilsho	927	14	internalized	internalize	VBN
cord-006229-7yoilsho	927	15	material	material	NN
cord-006229-7yoilsho	927	16	and	and	CC
cord-006229-7yoilsho	927	17	the	the	DT
cord-006229-7yoilsho	927	18	results	result	NNS
cord-006229-7yoilsho	927	19	were	be	VBD
cord-006229-7yoilsho	927	20	in	in	IN
cord-006229-7yoilsho	927	21	accordance	accordance	NN
cord-006229-7yoilsho	927	22	with	with	IN
cord-006229-7yoilsho	927	23	the	the	DT
cord-006229-7yoilsho	927	24	Transwell	Transwell	NNP
cord-006229-7yoilsho	927	25	TM	TM	NNP
cord-006229-7yoilsho	927	26	-data	-data	NNS
cord-006229-7yoilsho	927	27	.	.	.
cord-006229-7yoilsho	928	1	Additionally	additionally	RB
cord-006229-7yoilsho	928	2	,	,	,
cord-006229-7yoilsho	928	3	IBM	IBM	NNP
cord-006229-7yoilsho	928	4	investigations	investigation	NNS
cord-006229-7yoilsho	928	5	via	via	IN
cord-006229-7yoilsho	928	6	Particle	particle	NN
cord-006229-7yoilsho	928	7	-	-	HYPH
cord-006229-7yoilsho	928	8	Induced	Induced	NNP
cord-006229-7yoilsho	928	9	X	X	NNP
cord-006229-7yoilsho	928	10	-	-	NNP
cord-006229-7yoilsho	928	11	Ray	Ray	NNP
cord-006229-7yoilsho	928	12	Emission	Emission	NNP
cord-006229-7yoilsho	928	13	(	(	-LRB-
cord-006229-7yoilsho	928	14	PIXE	PIXE	NNP
cord-006229-7yoilsho	928	15	)	)	-RRB-
cord-006229-7yoilsho	928	16	showed	show	VBD
cord-006229-7yoilsho	928	17	intracellular	intracellular	JJ
cord-006229-7yoilsho	928	18	association	association	NN
cord-006229-7yoilsho	928	19	of	of	IN
cord-006229-7yoilsho	928	20	silver	silver	NN
cord-006229-7yoilsho	928	21	with	with	IN
cord-006229-7yoilsho	928	22	sulfur	sulfur	NN
cord-006229-7yoilsho	928	23	.	.	.
cord-006229-7yoilsho	929	1	The	the	DT
cord-006229-7yoilsho	929	2	quantification	quantification	NN
cord-006229-7yoilsho	929	3	of	of	IN
cord-006229-7yoilsho	929	4	silver	silver	JJ
cord-006229-7yoilsho	929	5	nanoparticle	nanoparticle	NN
cord-006229-7yoilsho	929	6	internalization	internalization	NN
cord-006229-7yoilsho	929	7	revealed	reveal	VBD
cord-006229-7yoilsho	929	8	a	a	DT
cord-006229-7yoilsho	929	9	clear	clear	JJ
cord-006229-7yoilsho	929	10	particle	particle	NN
cord-006229-7yoilsho	929	11	-	-	HYPH
cord-006229-7yoilsho	929	12	specific	specific	JJ
cord-006229-7yoilsho	929	13	and	and	CC
cord-006229-7yoilsho	929	14	a	a	DT
cord-006229-7yoilsho	929	15	coating	coating	NN
cord-006229-7yoilsho	929	16	-	-	HYPH
cord-006229-7yoilsho	929	17	related	relate	VBN
cord-006229-7yoilsho	929	18	uptake	uptake	NN
cord-006229-7yoilsho	929	19	.	.	.
cord-006229-7yoilsho	930	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	930	2	,	,	,
cord-006229-7yoilsho	930	3	a	a	DT
cord-006229-7yoilsho	930	4	high	high	JJ
cord-006229-7yoilsho	930	5	amount	amount	NN
cord-006229-7yoilsho	930	6	of	of	IN
cord-006229-7yoilsho	930	7	silver	silver	NN
cord-006229-7yoilsho	930	8	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	930	9	is	be	VBZ
cord-006229-7yoilsho	930	10	taken	take	VBN
cord-006229-7yoilsho	930	11	up	up	RP
cord-006229-7yoilsho	930	12	in	in	IN
cord-006229-7yoilsho	930	13	cell	cell	NN
cord-006229-7yoilsho	930	14	models	model	NNS
cord-006229-7yoilsho	930	15	of	of	IN
cord-006229-7yoilsho	930	16	higher	high	JJR
cord-006229-7yoilsho	930	17	complexity	complexity	NN
cord-006229-7yoilsho	930	18	.	.	.
cord-006229-7yoilsho	931	1	Thus	thus	RB
cord-006229-7yoilsho	931	2	,	,	,
cord-006229-7yoilsho	931	3	an	an	DT
cord-006229-7yoilsho	931	4	underestimation	underestimation	NN
cord-006229-7yoilsho	931	5	of	of	IN
cord-006229-7yoilsho	931	6	particle	particle	NN
cord-006229-7yoilsho	931	7	effects	effect	NNS
cord-006229-7yoilsho	931	8	in	in	IN
cord-006229-7yoilsho	931	9	vitro	vitro	FW
cord-006229-7yoilsho	931	10	might	may	MD
cord-006229-7yoilsho	931	11	be	be	VB
cord-006229-7yoilsho	931	12	prevented	prevent	VBN
cord-006229-7yoilsho	931	13	by	by	IN
cord-006229-7yoilsho	931	14	considering	consider	VBG
cord-006229-7yoilsho	931	15	cell	cell	NN
cord-006229-7yoilsho	931	16	models	model	NNS
cord-006229-7yoilsho	931	17	with	with	IN
cord-006229-7yoilsho	931	18	greater	great	JJR
cord-006229-7yoilsho	931	19	proximity	proximity	NN
cord-006229-7yoilsho	931	20	to	to	IN
cord-006229-7yoilsho	931	21	the	the	DT
cord-006229-7yoilsho	931	22	in	in	IN
cord-006229-7yoilsho	931	23	vivo	vivo	NN
cord-006229-7yoilsho	931	24	situation	situation	NN
cord-006229-7yoilsho	931	25	.	.	.
cord-006229-7yoilsho	932	1	Analyzing	analyze	VBG
cord-006229-7yoilsho	932	2	iron	iron	NN
cord-006229-7yoilsho	932	3	oxide	oxide	NN
cord-006229-7yoilsho	932	4	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	932	5	for	for	IN
cord-006229-7yoilsho	932	6	drug	drug	NN
cord-006229-7yoilsho	932	7	delivery	delivery	NN
cord-006229-7yoilsho	932	8	-innovative	-innovative	:
cord-006229-7yoilsho	932	9	investigation	investigation	NN
cord-006229-7yoilsho	932	10	tools	tool	NNS
cord-006229-7yoilsho	932	11	for	for	IN
cord-006229-7yoilsho	932	12	nanotoxicology	nanotoxicology	NN
cord-006229-7yoilsho	932	13	Nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	932	14	offer	offer	VBP
cord-006229-7yoilsho	932	15	promising	promise	VBG
cord-006229-7yoilsho	932	16	new	new	JJ
cord-006229-7yoilsho	932	17	possibilities	possibility	NNS
cord-006229-7yoilsho	932	18	for	for	IN
cord-006229-7yoilsho	932	19	medical	medical	JJ
cord-006229-7yoilsho	932	20	applications	application	NNS
cord-006229-7yoilsho	932	21	including	include	VBG
cord-006229-7yoilsho	932	22	therapy	therapy	NN
cord-006229-7yoilsho	932	23	and	and	CC
cord-006229-7yoilsho	932	24	diagnosis	diagnosis	NN
cord-006229-7yoilsho	932	25	of	of	IN
cord-006229-7yoilsho	932	26	various	various	JJ
cord-006229-7yoilsho	932	27	diseases	disease	NNS
cord-006229-7yoilsho	932	28	.	.	.
cord-006229-7yoilsho	933	1	Especially	especially	RB
cord-006229-7yoilsho	933	2	nanoparticle	nanoparticle	NN
cord-006229-7yoilsho	933	3	systems	system	NNS
cord-006229-7yoilsho	933	4	with	with	IN
cord-006229-7yoilsho	933	5	magnetic	magnetic	JJ
cord-006229-7yoilsho	933	6	cores	core	NNS
cord-006229-7yoilsho	933	7	provide	provide	VBP
cord-006229-7yoilsho	933	8	a	a	DT
cord-006229-7yoilsho	933	9	broad	broad	JJ
cord-006229-7yoilsho	933	10	application	application	NN
cord-006229-7yoilsho	933	11	spectrum	spectrum	NN
cord-006229-7yoilsho	933	12	as	as	IN
cord-006229-7yoilsho	933	13	contrast	contrast	NN
cord-006229-7yoilsho	933	14	agents	agent	NNS
cord-006229-7yoilsho	933	15	,	,	,
cord-006229-7yoilsho	933	16	magnetic	magnetic	JJ
cord-006229-7yoilsho	933	17	transporters	transporter	NNS
cord-006229-7yoilsho	933	18	,	,	,
cord-006229-7yoilsho	933	19	or	or	CC
cord-006229-7yoilsho	933	20	heat	heat	NN
cord-006229-7yoilsho	933	21	carriers	carrier	NNS
cord-006229-7yoilsho	933	22	in	in	IN
cord-006229-7yoilsho	933	23	hyperthermia	hyperthermia	NN
cord-006229-7yoilsho	933	24	treatment	treatment	NN
cord-006229-7yoilsho	933	25	.	.	.
cord-006229-7yoilsho	934	1	For	for	IN
cord-006229-7yoilsho	934	2	bench	bench	NN
cord-006229-7yoilsho	934	3	to	to	IN
cord-006229-7yoilsho	934	4	bedside	bedside	NN
cord-006229-7yoilsho	934	5	translation	translation	NN
cord-006229-7yoilsho	934	6	of	of	IN
cord-006229-7yoilsho	934	7	superparamagnetic	superparamagnetic	JJ
cord-006229-7yoilsho	934	8	iron	iron	NN
cord-006229-7yoilsho	934	9	oxide	oxide	NN
cord-006229-7yoilsho	934	10	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	934	11	(	(	-LRB-
cord-006229-7yoilsho	934	12	SPIONs	spion	NNS
cord-006229-7yoilsho	934	13	)	)	-RRB-
cord-006229-7yoilsho	934	14	for	for	IN
cord-006229-7yoilsho	934	15	medical	medical	JJ
cord-006229-7yoilsho	934	16	applications	application	NNS
cord-006229-7yoilsho	934	17	,	,	,
cord-006229-7yoilsho	934	18	safety	safety	NN
cord-006229-7yoilsho	934	19	issues	issue	NNS
cord-006229-7yoilsho	934	20	have	have	VBP
cord-006229-7yoilsho	934	21	to	to	TO
cord-006229-7yoilsho	934	22	be	be	VB
cord-006229-7yoilsho	934	23	clarified	clarify	VBN
cord-006229-7yoilsho	934	24	.	.	.
cord-006229-7yoilsho	935	1	For	for	IN
cord-006229-7yoilsho	935	2	that	that	DT
cord-006229-7yoilsho	935	3	,	,	,
cord-006229-7yoilsho	935	4	reliable	reliable	JJ
cord-006229-7yoilsho	935	5	standards	standard	NNS
cord-006229-7yoilsho	935	6	must	must	MD
cord-006229-7yoilsho	935	7	be	be	VB
cord-006229-7yoilsho	935	8	established	establish	VBN
cord-006229-7yoilsho	935	9	on	on	IN
cord-006229-7yoilsho	935	10	the	the	DT
cord-006229-7yoilsho	935	11	basis	basis	NN
cord-006229-7yoilsho	935	12	of	of	IN
cord-006229-7yoilsho	935	13	comprehensively	comprehensively	RB
cord-006229-7yoilsho	935	14	validated	validate	VBN
cord-006229-7yoilsho	935	15	physicochemical	physicochemical	JJ
cord-006229-7yoilsho	935	16	and	and	CC
cord-006229-7yoilsho	935	17	biological	biological	JJ
cord-006229-7yoilsho	935	18	characterization	characterization	NN
cord-006229-7yoilsho	935	19	methods	method	NNS
cord-006229-7yoilsho	935	20	.	.	.
cord-006229-7yoilsho	936	1	SPIONs	spion	NNS
cord-006229-7yoilsho	936	2	consisting	consist	VBG
cord-006229-7yoilsho	936	3	of	of	IN
cord-006229-7yoilsho	936	4	maghemite	maghemite	NN
cord-006229-7yoilsho	936	5	and	and	CC
cord-006229-7yoilsho	936	6	magnetite	magnetite	NN
cord-006229-7yoilsho	936	7	are	be	VBP
cord-006229-7yoilsho	936	8	usually	usually	RB
cord-006229-7yoilsho	936	9	of	of	IN
cord-006229-7yoilsho	936	10	brown	brown	JJ
cord-006229-7yoilsho	936	11	or	or	CC
cord-006229-7yoilsho	936	12	black	black	JJ
cord-006229-7yoilsho	936	13	color	color	NN
cord-006229-7yoilsho	936	14	.	.	.
cord-006229-7yoilsho	937	1	Due	due	IN
cord-006229-7yoilsho	937	2	to	to	IN
cord-006229-7yoilsho	937	3	these	these	DT
cord-006229-7yoilsho	937	4	special	special	JJ
cord-006229-7yoilsho	937	5	properties	property	NNS
cord-006229-7yoilsho	937	6	,	,	,
cord-006229-7yoilsho	937	7	SPIONs	spion	NNS
cord-006229-7yoilsho	937	8	and	and	CC
cord-006229-7yoilsho	937	9	other	other	JJ
cord-006229-7yoilsho	937	10	metal	metal	NN
cord-006229-7yoilsho	937	11	oxide	oxide	NN
cord-006229-7yoilsho	937	12	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	937	13	are	be	VBP
cord-006229-7yoilsho	937	14	prone	prone	JJ
cord-006229-7yoilsho	937	15	to	to	TO
cord-006229-7yoilsho	937	16	interfere	interfere	VB
cord-006229-7yoilsho	937	17	with	with	IN
cord-006229-7yoilsho	937	18	classical	classical	JJ
cord-006229-7yoilsho	937	19	toxicological	toxicological	JJ
cord-006229-7yoilsho	937	20	assays	assay	NNS
cord-006229-7yoilsho	937	21	relying	rely	VBG
cord-006229-7yoilsho	937	22	on	on	IN
cord-006229-7yoilsho	937	23	optical	optical	JJ
cord-006229-7yoilsho	937	24	detection	detection	NN
cord-006229-7yoilsho	937	25	of	of	IN
cord-006229-7yoilsho	937	26	colorimetric	colorimetric	JJ
cord-006229-7yoilsho	937	27	,	,	,
cord-006229-7yoilsho	937	28	fluorescence	fluorescence	NN
cord-006229-7yoilsho	937	29	or	or	CC
cord-006229-7yoilsho	937	30	luminescence	luminescence	NN
cord-006229-7yoilsho	937	31	signals	signal	NNS
cord-006229-7yoilsho	937	32	.	.	.
cord-006229-7yoilsho	938	1	Particularly	particularly	RB
cord-006229-7yoilsho	938	2	,	,	,
cord-006229-7yoilsho	938	3	nanoparticle	nanoparticle	NN
cord-006229-7yoilsho	938	4	concentration	concentration	NN
cord-006229-7yoilsho	938	5	and	and	CC
cord-006229-7yoilsho	938	6	cellular	cellular	JJ
cord-006229-7yoilsho	938	7	uptake	uptake	NN
cord-006229-7yoilsho	938	8	are	be	VBP
cord-006229-7yoilsho	938	9	further	further	RB
cord-006229-7yoilsho	938	10	influencing	influence	VBG
cord-006229-7yoilsho	938	11	factors	factor	NNS
cord-006229-7yoilsho	938	12	.	.	.
cord-006229-7yoilsho	939	1	Consequently	consequently	RB
cord-006229-7yoilsho	939	2	,	,	,
cord-006229-7yoilsho	939	3	for	for	IN
cord-006229-7yoilsho	939	4	reliable	reliable	JJ
cord-006229-7yoilsho	939	5	analysis	analysis	NN
cord-006229-7yoilsho	939	6	of	of	IN
cord-006229-7yoilsho	939	7	nanoparticle	nanoparticle	NN
cord-006229-7yoilsho	939	8	mediated	mediate	VBN
cord-006229-7yoilsho	939	9	effects	effect	NNS
cord-006229-7yoilsho	939	10	,	,	,
cord-006229-7yoilsho	939	11	alternative	alternative	JJ
cord-006229-7yoilsho	939	12	robust	robust	JJ
cord-006229-7yoilsho	939	13	and	and	CC
cord-006229-7yoilsho	939	14	interference	interference	NN
cord-006229-7yoilsho	939	15	-	-	HYPH
cord-006229-7yoilsho	939	16	free	free	JJ
cord-006229-7yoilsho	939	17	readouts	readout	NNS
cord-006229-7yoilsho	939	18	have	have	VBP
cord-006229-7yoilsho	939	19	to	to	TO
cord-006229-7yoilsho	939	20	be	be	VB
cord-006229-7yoilsho	939	21	established	establish	VBN
cord-006229-7yoilsho	939	22	.	.	.
cord-006229-7yoilsho	940	1	Based	base	VBN
cord-006229-7yoilsho	940	2	on	on	IN
cord-006229-7yoilsho	940	3	long	long	JJ
cord-006229-7yoilsho	940	4	lasting	lasting	JJ
cord-006229-7yoilsho	940	5	experience	experience	NN
cord-006229-7yoilsho	940	6	working	work	VBG
cord-006229-7yoilsho	940	7	with	with	IN
cord-006229-7yoilsho	940	8	SPIONs	spion	NNS
cord-006229-7yoilsho	940	9	,	,	,
cord-006229-7yoilsho	940	10	we	-PRON-	PRP
cord-006229-7yoilsho	940	11	suggest	suggest	VBP
cord-006229-7yoilsho	940	12	a	a	DT
cord-006229-7yoilsho	940	13	combination	combination	NN
cord-006229-7yoilsho	940	14	of	of	IN
cord-006229-7yoilsho	940	15	complementary	complementary	JJ
cord-006229-7yoilsho	940	16	methods	method	NNS
cord-006229-7yoilsho	940	17	to	to	TO
cord-006229-7yoilsho	940	18	analyse	analyse	VB
cord-006229-7yoilsho	940	19	nanoparticle	nanoparticle	NN
cord-006229-7yoilsho	940	20	-	-	HYPH
cord-006229-7yoilsho	940	21	mediated	mediate	VBN
cord-006229-7yoilsho	940	22	effects	effect	NNS
cord-006229-7yoilsho	940	23	:	:	:
cord-006229-7yoilsho	940	24	Multiparameter	Multiparameter	NNP
cord-006229-7yoilsho	940	25	analyses	analysis	NNS
cord-006229-7yoilsho	940	26	in	in	IN
cord-006229-7yoilsho	940	27	flow	flow	NN
cord-006229-7yoilsho	940	28	cytometry	cytometry	NN
cord-006229-7yoilsho	940	29	deliver	deliver	VBP
cord-006229-7yoilsho	940	30	statistically	statistically	RB
cord-006229-7yoilsho	940	31	relevant	relevant	JJ
cord-006229-7yoilsho	940	32	data	datum	NNS
cord-006229-7yoilsho	940	33	and	and	CC
cord-006229-7yoilsho	940	34	link	link	NN
cord-006229-7yoilsho	940	35	uptake	uptake	NN
cord-006229-7yoilsho	940	36	of	of	IN
cord-006229-7yoilsho	940	37	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	940	38	(	(	-LRB-
cord-006229-7yoilsho	940	39	side	side	NN
cord-006229-7yoilsho	940	40	scatter	scatter	NN
cord-006229-7yoilsho	940	41	increase	increase	NN
cord-006229-7yoilsho	940	42	)	)	-RRB-
cord-006229-7yoilsho	940	43	with	with	IN
cord-006229-7yoilsho	940	44	cellular	cellular	JJ
cord-006229-7yoilsho	940	45	effects	effect	NNS
cord-006229-7yoilsho	940	46	in	in	IN
cord-006229-7yoilsho	940	47	a	a	DT
cord-006229-7yoilsho	940	48	high	high	JJ
cord-006229-7yoilsho	940	49	-	-	HYPH
cord-006229-7yoilsho	940	50	content	content	NN
cord-006229-7yoilsho	940	51	style	style	NN
cord-006229-7yoilsho	940	52	.	.	.
cord-006229-7yoilsho	941	1	Combination	combination	NN
cord-006229-7yoilsho	941	2	of	of	IN
cord-006229-7yoilsho	941	3	noninvasive	noninvasive	JJ
cord-006229-7yoilsho	941	4	,	,	,
cord-006229-7yoilsho	941	5	label	label	NN
cord-006229-7yoilsho	941	6	-	-	HYPH
cord-006229-7yoilsho	941	7	free	free	JJ
cord-006229-7yoilsho	941	8	impedance	impedance	NN
cord-006229-7yoilsho	941	9	measurements	measurement	NNS
cord-006229-7yoilsho	941	10	(	(	-LRB-
cord-006229-7yoilsho	941	11	xCELLigence	xcelligence	NN
cord-006229-7yoilsho	941	12	system	system	NN
cord-006229-7yoilsho	941	13	)	)	-RRB-
cord-006229-7yoilsho	941	14	with	with	IN
cord-006229-7yoilsho	941	15	real	real	JJ
cord-006229-7yoilsho	941	16	-	-	HYPH
cord-006229-7yoilsho	941	17	time	time	NN
cord-006229-7yoilsho	941	18	(	(	-LRB-
cord-006229-7yoilsho	941	19	fluorescence	fluorescence	NN
cord-006229-7yoilsho	941	20	)	)	-RRB-
cord-006229-7yoilsho	941	21	microscopy	microscopy	NN
cord-006229-7yoilsho	941	22	enables	enable	VBZ
cord-006229-7yoilsho	941	23	us	-PRON-	PRP
cord-006229-7yoilsho	941	24	to	to	TO
cord-006229-7yoilsho	941	25	monitor	monitor	VB
cord-006229-7yoilsho	941	26	cellular	cellular	JJ
cord-006229-7yoilsho	941	27	proliferation	proliferation	NN
cord-006229-7yoilsho	941	28	and	and	CC
cord-006229-7yoilsho	941	29	morphology	morphology	NN
cord-006229-7yoilsho	941	30	over	over	IN
cord-006229-7yoilsho	941	31	several	several	JJ
cord-006229-7yoilsho	941	32	days	day	NNS
cord-006229-7yoilsho	941	33	without	without	IN
cord-006229-7yoilsho	941	34	interference	interference	NN
cord-006229-7yoilsho	941	35	by	by	IN
cord-006229-7yoilsho	941	36	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	941	37	.	.	.
cord-006229-7yoilsho	942	1	Additional	additional	JJ
cord-006229-7yoilsho	942	2	experiments	experiment	NNS
cord-006229-7yoilsho	942	3	in	in	IN
cord-006229-7yoilsho	942	4	multicellular	multicellular	JJ
cord-006229-7yoilsho	942	5	tumor	tumor	NN
cord-006229-7yoilsho	942	6	spheroids	spheroid	NNS
cord-006229-7yoilsho	942	7	provide	provide	VBP
cord-006229-7yoilsho	942	8	information	information	NN
cord-006229-7yoilsho	942	9	about	about	IN
cord-006229-7yoilsho	942	10	tissue	tissue	NN
cord-006229-7yoilsho	942	11	infiltration	infiltration	NN
cord-006229-7yoilsho	942	12	and	and	CC
cord-006229-7yoilsho	942	13	thus	thus	RB
cord-006229-7yoilsho	942	14	,	,	,
cord-006229-7yoilsho	942	15	more	more	RBR
cord-006229-7yoilsho	942	16	closely	closely	RB
cord-006229-7yoilsho	942	17	resemble	resemble	VB
cord-006229-7yoilsho	942	18	the	the	DT
cord-006229-7yoilsho	942	19	in	in	IN
cord-006229-7yoilsho	942	20	vivo	vivo	NN
cord-006229-7yoilsho	942	21	situation	situation	NN
cord-006229-7yoilsho	942	22	.	.	.
cord-006229-7yoilsho	943	1	Using	use	VBG
cord-006229-7yoilsho	943	2	those	those	DT
cord-006229-7yoilsho	943	3	complementary	complementary	JJ
cord-006229-7yoilsho	943	4	methods	method	NNS
cord-006229-7yoilsho	943	5	,	,	,
cord-006229-7yoilsho	943	6	several	several	JJ
cord-006229-7yoilsho	943	7	drug	drug	NN
cord-006229-7yoilsho	943	8	-	-	HYPH
cord-006229-7yoilsho	943	9	loaded	load	VBN
cord-006229-7yoilsho	943	10	SPION	SPION	NNP
cord-006229-7yoilsho	943	11	systems	system	NNS
cord-006229-7yoilsho	943	12	dedicated	dedicate	VBN
cord-006229-7yoilsho	943	13	for	for	IN
cord-006229-7yoilsho	943	14	medical	medical	JJ
cord-006229-7yoilsho	943	15	applications	application	NNS
cord-006229-7yoilsho	943	16	have	have	VBP
cord-006229-7yoilsho	943	17	been	be	VBN
cord-006229-7yoilsho	943	18	successfully	successfully	RB
cord-006229-7yoilsho	943	19	characterized	characterize	VBN
cord-006229-7yoilsho	943	20	previously	previously	RB
cord-006229-7yoilsho	943	21	.	.	.
cord-006229-7yoilsho	944	1	In	in	IN
cord-006229-7yoilsho	944	2	sum	sum	NN
cord-006229-7yoilsho	944	3	,	,	,
cord-006229-7yoilsho	944	4	nanotoxicology	nanotoxicology	NN
cord-006229-7yoilsho	944	5	is	be	VBZ
cord-006229-7yoilsho	944	6	a	a	DT
cord-006229-7yoilsho	944	7	complex	complex	JJ
cord-006229-7yoilsho	944	8	and	and	CC
cord-006229-7yoilsho	944	9	interdisciplinary	interdisciplinary	JJ
cord-006229-7yoilsho	944	10	challenge	challenge	NN
cord-006229-7yoilsho	944	11	,	,	,
cord-006229-7yoilsho	944	12	where	where	WRB
cord-006229-7yoilsho	944	13	physicochemical	physicochemical	JJ
cord-006229-7yoilsho	944	14	parameters	parameter	NNS
cord-006229-7yoilsho	944	15	,	,	,
cord-006229-7yoilsho	944	16	as	as	RB
cord-006229-7yoilsho	944	17	well	well	RB
cord-006229-7yoilsho	944	18	as	as	IN
cord-006229-7yoilsho	944	19	in	in	IN
cord-006229-7yoilsho	944	20	vitro	vitro	FW
cord-006229-7yoilsho	944	21	and	and	CC
cord-006229-7yoilsho	944	22	in	in	IN
cord-006229-7yoilsho	944	23	vivo	vivo	NN
cord-006229-7yoilsho	944	24	behavior	behavior	NN
cord-006229-7yoilsho	944	25	of	of	IN
cord-006229-7yoilsho	944	26	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	944	27	have	have	VBP
cord-006229-7yoilsho	944	28	to	to	TO
cord-006229-7yoilsho	944	29	be	be	VB
cord-006229-7yoilsho	944	30	considered	consider	VBN
cord-006229-7yoilsho	944	31	.	.	.
cord-006229-7yoilsho	945	1	To	to	TO
cord-006229-7yoilsho	945	2	address	address	VB
cord-006229-7yoilsho	945	3	these	these	DT
cord-006229-7yoilsho	945	4	basic	basic	JJ
cord-006229-7yoilsho	945	5	requirements	requirement	NNS
cord-006229-7yoilsho	945	6	,	,	,
cord-006229-7yoilsho	945	7	we	-PRON-	PRP
cord-006229-7yoilsho	945	8	are	be	VBP
cord-006229-7yoilsho	945	9	working	work	VBG
cord-006229-7yoilsho	945	10	on	on	IN
cord-006229-7yoilsho	945	11	a	a	DT
cord-006229-7yoilsho	945	12	stringent	stringent	JJ
cord-006229-7yoilsho	945	13	standardized	standardized	JJ
cord-006229-7yoilsho	945	14	road	road	NN
cord-006229-7yoilsho	945	15	of	of	IN
cord-006229-7yoilsho	945	16	characterization	characterization	NN
cord-006229-7yoilsho	945	17	for	for	IN
cord-006229-7yoilsho	945	18	iron	iron	NN
cord-006229-7yoilsho	945	19	oxide	oxide	NN
cord-006229-7yoilsho	945	20	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	945	21	synthesized	synthesize	VBN
cord-006229-7yoilsho	945	22	for	for	IN
cord-006229-7yoilsho	945	23	medical	medical	JJ
cord-006229-7yoilsho	945	24	applications	application	NNS
cord-006229-7yoilsho	945	25	.	.	.
cord-006229-7yoilsho	946	1	Reference	reference	NN
cord-006229-7yoilsho	946	2	:	:	:
cord-006229-7yoilsho	947	1	Lyer	Lyer	NNP
cord-006229-7yoilsho	947	2	S	S	NNP
cord-006229-7yoilsho	947	3	,	,	,
cord-006229-7yoilsho	947	4	Tietze	Tietze	NNP
cord-006229-7yoilsho	947	5	R	R	NNP
cord-006229-7yoilsho	947	6	,	,	,
cord-006229-7yoilsho	947	7	Unterweger	Unterweger	NNP
cord-006229-7yoilsho	947	8	H	H	NNP
cord-006229-7yoilsho	947	9	,	,	,
cord-006229-7yoilsho	947	10	Zaloga	Zaloga	NNP
cord-006229-7yoilsho	947	11	J	J	NNP
cord-006229-7yoilsho	947	12	,	,	,
cord-006229-7yoilsho	947	13	Singh	Singh	NNP
cord-006229-7yoilsho	947	14	R	R	NNP
cord-006229-7yoilsho	947	15	,	,	,
cord-006229-7yoilsho	947	16	Matuszak	Matuszak	NNP
cord-006229-7yoilsho	947	17	J	J	NNP
cord-006229-7yoilsho	947	18	,	,	,
cord-006229-7yoilsho	947	19	Poettler	Poettler	NNP
cord-006229-7yoilsho	947	20	M	M	NNP
cord-006229-7yoilsho	947	21	,	,	,
cord-006229-7yoilsho	947	22	Friedrich	Friedrich	NNP
cord-006229-7yoilsho	947	23	RP	RP	NNP
cord-006229-7yoilsho	947	24	,	,	,
cord-006229-7yoilsho	947	25	Duerr	Duerr	NNP
cord-006229-7yoilsho	947	26	S	S	NNP
cord-006229-7yoilsho	947	27	,	,	,
cord-006229-7yoilsho	947	28	Cicha	Cicha	NNP
cord-006229-7yoilsho	947	29	I	-PRON-	PRP
cord-006229-7yoilsho	947	30	,	,	,
cord-006229-7yoilsho	947	31	Janko	Janko	NNP
cord-006229-7yoilsho	947	32	C	C	NNP
cord-006229-7yoilsho	947	33	,	,	,
cord-006229-7yoilsho	947	34	Alexiou	Alexiou	NNP
cord-006229-7yoilsho	947	35	C.	C.	NNP
cord-006229-7yoilsho	947	36	Nanomedical	Nanomedical	NNP
cord-006229-7yoilsho	947	37	innovation	innovation	NN
cord-006229-7yoilsho	947	38	:	:	:
cord-006229-7yoilsho	947	39	the	the	DT
cord-006229-7yoilsho	947	40	SEON	SEON	NNP
cord-006229-7yoilsho	947	41	concept	concept	NN
cord-006229-7yoilsho	947	42	for	for	IN
cord-006229-7yoilsho	947	43	an	an	DT
cord-006229-7yoilsho	947	44	improved	improved	JJ
cord-006229-7yoilsho	947	45	cancer	cancer	NN
cord-006229-7yoilsho	947	46	therapy	therapy	NN
cord-006229-7yoilsho	947	47	with	with	IN
cord-006229-7yoilsho	947	48	magnetic	magnetic	JJ
cord-006229-7yoilsho	947	49	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	947	50	.	.	.
cord-006229-7yoilsho	948	1	Nanomedicine	Nanomedicine	NNP
cord-006229-7yoilsho	948	2	(	(	-LRB-
cord-006229-7yoilsho	948	3	Lond	Lond	NNP
cord-006229-7yoilsho	948	4	)	)	-RRB-
cord-006229-7yoilsho	948	5	.	.	.
cord-006229-7yoilsho	948	6	2015	2015	CD
cord-006229-7yoilsho	948	7	;	;	:
cord-006229-7yoilsho	948	8	10	10	CD
cord-006229-7yoilsho	948	9	(	(	-LRB-
cord-006229-7yoilsho	948	10	21	21	CD
cord-006229-7yoilsho	948	11	)	)	-RRB-
cord-006229-7yoilsho	948	12	Acrylamide	acrylamide	NN
cord-006229-7yoilsho	948	13	(	(	-LRB-
cord-006229-7yoilsho	948	14	AA	AA	NNP
cord-006229-7yoilsho	948	15	)	)	-RRB-
cord-006229-7yoilsho	948	16	is	be	VBZ
cord-006229-7yoilsho	948	17	an	an	DT
cord-006229-7yoilsho	948	18	α	α	NN
cord-006229-7yoilsho	948	19	,	,	,
cord-006229-7yoilsho	948	20	β	β	NN
cord-006229-7yoilsho	948	21	-	-	HYPH
cord-006229-7yoilsho	948	22	unsaturated	unsaturated	JJ
cord-006229-7yoilsho	948	23	compound	compound	NN
cord-006229-7yoilsho	948	24	,	,	,
cord-006229-7yoilsho	948	25	which	which	WDT
cord-006229-7yoilsho	948	26	is	be	VBZ
cord-006229-7yoilsho	948	27	categorized	categorize	VBN
cord-006229-7yoilsho	948	28	as	as	RB
cord-006229-7yoilsho	948	29	probably	probably	RB
cord-006229-7yoilsho	948	30	carcinogenic	carcinogenic	JJ
cord-006229-7yoilsho	948	31	to	to	IN
cord-006229-7yoilsho	948	32	humans	human	NNS
cord-006229-7yoilsho	948	33	[	[	-LRB-
cord-006229-7yoilsho	948	34	1	1	CD
cord-006229-7yoilsho	948	35	,	,	,
cord-006229-7yoilsho	948	36	2	2	CD
cord-006229-7yoilsho	948	37	]	]	-RRB-
cord-006229-7yoilsho	948	38	.	.	.
cord-006229-7yoilsho	949	1	AA	AA	NNP
cord-006229-7yoilsho	949	2	is	be	VBZ
cord-006229-7yoilsho	949	3	known	know	VBN
cord-006229-7yoilsho	949	4	to	to	TO
cord-006229-7yoilsho	949	5	arise	arise	VB
cord-006229-7yoilsho	949	6	in	in	IN
cord-006229-7yoilsho	949	7	foods	food	NNS
cord-006229-7yoilsho	949	8	by	by	IN
cord-006229-7yoilsho	949	9	heat	heat	NN
cord-006229-7yoilsho	949	10	treatment	treatment	NN
cord-006229-7yoilsho	949	11	in	in	IN
cord-006229-7yoilsho	949	12	the	the	DT
cord-006229-7yoilsho	949	13	course	course	NN
cord-006229-7yoilsho	949	14	of	of	IN
cord-006229-7yoilsho	949	15	the	the	DT
cord-006229-7yoilsho	949	16	Maillard	Maillard	NNP
cord-006229-7yoilsho	949	17	reaction	reaction	NN
cord-006229-7yoilsho	949	18	between	between	IN
cord-006229-7yoilsho	949	19	reducing	reduce	VBG
cord-006229-7yoilsho	949	20	sugars	sugar	NNS
cord-006229-7yoilsho	949	21	and	and	CC
cord-006229-7yoilsho	949	22	amino	amino	JJ
cord-006229-7yoilsho	949	23	acids	acid	NNS
cord-006229-7yoilsho	949	24	at	at	IN
cord-006229-7yoilsho	949	25	processing	processing	NN
cord-006229-7yoilsho	949	26	temperatures	temperature	NNS
cord-006229-7yoilsho	949	27	>	>	XX
cord-006229-7yoilsho	949	28	120	120	CD
cord-006229-7yoilsho	949	29	°	°	NN
cord-006229-7yoilsho	949	30	C	c	NN
cord-006229-7yoilsho	949	31	[	[	-LRB-
cord-006229-7yoilsho	949	32	3	3	CD
cord-006229-7yoilsho	949	33	]	]	-RRB-
cord-006229-7yoilsho	949	34	.	.	.
cord-006229-7yoilsho	950	1	Dietary	dietary	JJ
cord-006229-7yoilsho	950	2	AA	AA	NNP
cord-006229-7yoilsho	950	3	exposure	exposure	NN
cord-006229-7yoilsho	950	4	has	have	VBZ
cord-006229-7yoilsho	950	5	mainly	mainly	RB
cord-006229-7yoilsho	950	6	been	be	VBN
cord-006229-7yoilsho	950	7	estimated	estimate	VBN
cord-006229-7yoilsho	950	8	on	on	IN
cord-006229-7yoilsho	950	9	the	the	DT
cord-006229-7yoilsho	950	10	basis	basis	NN
cord-006229-7yoilsho	950	11	of	of	IN
cord-006229-7yoilsho	950	12	dietary	dietary	JJ
cord-006229-7yoilsho	950	13	recall	recall	NN
cord-006229-7yoilsho	950	14	,	,	,
cord-006229-7yoilsho	950	15	assessing	assess	VBG
cord-006229-7yoilsho	950	16	consumption	consumption	NN
cord-006229-7yoilsho	950	17	of	of	IN
cord-006229-7yoilsho	950	18	foods	food	NNS
cord-006229-7yoilsho	950	19	with	with	IN
cord-006229-7yoilsho	950	20	known	know	VBN
cord-006229-7yoilsho	950	21	AA	AA	NNP
cord-006229-7yoilsho	950	22	contents	content	NNS
cord-006229-7yoilsho	950	23	.	.	.
cord-006229-7yoilsho	951	1	The	the	DT
cord-006229-7yoilsho	951	2	use	use	NN
cord-006229-7yoilsho	951	3	of	of	IN
cord-006229-7yoilsho	951	4	human	human	JJ
cord-006229-7yoilsho	951	5	biomarkers	biomarker	NNS
cord-006229-7yoilsho	951	6	of	of	IN
cord-006229-7yoilsho	951	7	AA	AA	NNP
cord-006229-7yoilsho	951	8	exposure	exposure	NN
cord-006229-7yoilsho	951	9	,	,	,
cord-006229-7yoilsho	951	10	primarily	primarily	RB
cord-006229-7yoilsho	951	11	haemoglobin	haemoglobin	NN
cord-006229-7yoilsho	951	12	adducts	adduct	NNS
cord-006229-7yoilsho	951	13	of	of	IN
cord-006229-7yoilsho	951	14	AA	AA	NNP
cord-006229-7yoilsho	951	15	and	and	CC
cord-006229-7yoilsho	951	16	its	-PRON-	PRP$
cord-006229-7yoilsho	951	17	genotoxic	genotoxic	JJ
cord-006229-7yoilsho	951	18	metabolite	metabolite	NN
cord-006229-7yoilsho	951	19	,	,	,
cord-006229-7yoilsho	951	20	glycidamide	glycidamide	NNP
cord-006229-7yoilsho	951	21	(	(	-LRB-
cord-006229-7yoilsho	951	22	GA	GA	NNP
cord-006229-7yoilsho	951	23	)	)	-RRB-
cord-006229-7yoilsho	951	24	in	in	IN
cord-006229-7yoilsho	951	25	red	red	JJ
cord-006229-7yoilsho	951	26	blood	blood	NN
cord-006229-7yoilsho	951	27	cells	cell	NNS
cord-006229-7yoilsho	951	28	,	,	,
cord-006229-7yoilsho	951	29	as	as	RB
cord-006229-7yoilsho	951	30	well	well	RB
cord-006229-7yoilsho	951	31	as	as	IN
cord-006229-7yoilsho	951	32	mercapturic	mercapturic	JJ
cord-006229-7yoilsho	951	33	acids	acid	NNS
cord-006229-7yoilsho	951	34	excreted	excrete	VBN
cord-006229-7yoilsho	951	35	in	in	IN
cord-006229-7yoilsho	951	36	the	the	DT
cord-006229-7yoilsho	951	37	urine	urine	NN
cord-006229-7yoilsho	951	38	,	,	,
cord-006229-7yoilsho	951	39	is	be	VBZ
cord-006229-7yoilsho	951	40	a	a	DT
cord-006229-7yoilsho	951	41	promising	promising	JJ
cord-006229-7yoilsho	951	42	alternative	alternative	NN
cord-006229-7yoilsho	951	43	.	.	.
cord-006229-7yoilsho	952	1	Such	such	JJ
cord-006229-7yoilsho	952	2	biomarkers	biomarker	NNS
cord-006229-7yoilsho	952	3	are	be	VBP
cord-006229-7yoilsho	952	4	to	to	TO
cord-006229-7yoilsho	952	5	be	be	VB
cord-006229-7yoilsho	952	6	validated	validate	VBN
cord-006229-7yoilsho	952	7	by	by	IN
cord-006229-7yoilsho	952	8	exact	exact	JJ
cord-006229-7yoilsho	952	9	measurement	measurement	NN
cord-006229-7yoilsho	952	10	of	of	IN
cord-006229-7yoilsho	952	11	AA	AA	NNP
cord-006229-7yoilsho	952	12	uptake	uptake	NN
cord-006229-7yoilsho	952	13	in	in	IN
cord-006229-7yoilsho	952	14	duplicates	duplicate	NNS
cord-006229-7yoilsho	952	15	of	of	IN
cord-006229-7yoilsho	952	16	food	food	NN
cord-006229-7yoilsho	952	17	as	as	IN
cord-006229-7yoilsho	952	18	consumed	consume	VBN
cord-006229-7yoilsho	952	19	(	(	-LRB-
cord-006229-7yoilsho	952	20	duplicate	duplicate	JJ
cord-006229-7yoilsho	952	21	diet	diet	NN
cord-006229-7yoilsho	952	22	studies	study	NNS
cord-006229-7yoilsho	952	23	)	)	-RRB-
cord-006229-7yoilsho	952	24	[	[	-LRB-
cord-006229-7yoilsho	952	25	4	4	CD
cord-006229-7yoilsho	952	26	]	]	-RRB-
cord-006229-7yoilsho	952	27	.	.	.
cord-006229-7yoilsho	953	1	We	-PRON-	PRP
cord-006229-7yoilsho	953	2	here	here	RB
cord-006229-7yoilsho	953	3	present	present	VBP
cord-006229-7yoilsho	953	4	results	result	NNS
cord-006229-7yoilsho	953	5	of	of	IN
cord-006229-7yoilsho	953	6	a	a	DT
cord-006229-7yoilsho	953	7	nine	nine	CD
cord-006229-7yoilsho	953	8	-	-	HYPH
cord-006229-7yoilsho	953	9	day	day	NN
cord-006229-7yoilsho	953	10	human	human	JJ
cord-006229-7yoilsho	953	11	intervention	intervention	NN
cord-006229-7yoilsho	953	12	study	study	NN
cord-006229-7yoilsho	953	13	with	with	IN
cord-006229-7yoilsho	953	14	14	14	CD
cord-006229-7yoilsho	953	15	healthy	healthy	JJ
cord-006229-7yoilsho	953	16	male	male	JJ
cord-006229-7yoilsho	953	17	volunteers	volunteer	NNS
cord-006229-7yoilsho	953	18	.	.	.
cord-006229-7yoilsho	954	1	AA	AA	NNP
cord-006229-7yoilsho	954	2	contents	content	NNS
cord-006229-7yoilsho	954	3	were	be	VBD
cord-006229-7yoilsho	954	4	determined	determine	VBN
cord-006229-7yoilsho	954	5	in	in	IN
cord-006229-7yoilsho	954	6	duplicates	duplicate	NNS
cord-006229-7yoilsho	954	7	of	of	IN
cord-006229-7yoilsho	954	8	servings	serving	NNS
cord-006229-7yoilsho	954	9	as	as	IN
cord-006229-7yoilsho	954	10	consumed	consume	VBN
cord-006229-7yoilsho	954	11	and	and	CC
cord-006229-7yoilsho	954	12	kinetics	kinetic	NNS
cord-006229-7yoilsho	954	13	of	of	IN
cord-006229-7yoilsho	954	14	AA	AA	NNP
cord-006229-7yoilsho	954	15	-	-	HYPH
cord-006229-7yoilsho	954	16	associated	associate	VBN
cord-006229-7yoilsho	954	17	mercapturic	mercapturic	JJ
cord-006229-7yoilsho	954	18	acids	acid	NNS
cord-006229-7yoilsho	954	19	(	(	-LRB-
cord-006229-7yoilsho	954	20	AAMA	AAMA	NNP
cord-006229-7yoilsho	954	21	and	and	CC
cord-006229-7yoilsho	954	22	GAMA	GAMA	NNP
cord-006229-7yoilsho	954	23	)	)	-RRB-
cord-006229-7yoilsho	954	24	monitored	monitor	VBD
cord-006229-7yoilsho	954	25	in	in	IN
cord-006229-7yoilsho	954	26	total	total	JJ
cord-006229-7yoilsho	954	27	urine	urine	NN
cord-006229-7yoilsho	954	28	[	[	-LRB-
cord-006229-7yoilsho	954	29	5	5	CD
cord-006229-7yoilsho	954	30	]	]	-RRB-
cord-006229-7yoilsho	954	31	.	.	.
cord-006229-7yoilsho	955	1	The	the	DT
cord-006229-7yoilsho	955	2	study	study	NN
cord-006229-7yoilsho	955	3	design	design	NN
cord-006229-7yoilsho	955	4	included	include	VBD
cord-006229-7yoilsho	955	5	washout	washout	NN
cord-006229-7yoilsho	955	6	periods	period	NNS
cord-006229-7yoilsho	955	7	with	with	IN
cord-006229-7yoilsho	955	8	an	an	DT
cord-006229-7yoilsho	955	9	AA	AA	NNP
cord-006229-7yoilsho	955	10	-	-	HYPH
cord-006229-7yoilsho	955	11	minimized	minimize	VBN
cord-006229-7yoilsho	955	12	diet	diet	NN
cord-006229-7yoilsho	955	13	(	(	-LRB-
cord-006229-7yoilsho	955	14	21	21	CD
cord-006229-7yoilsho	955	15	-41	-41	NN
cord-006229-7yoilsho	955	16	ng	ng	NN
cord-006229-7yoilsho	955	17	/kg	/kg	NNP
cord-006229-7yoilsho	955	18	bw	bw	NNP
cord-006229-7yoilsho	955	19	)	)	-RRB-
cord-006229-7yoilsho	955	20	,	,	,
cord-006229-7yoilsho	955	21	a	a	DT
cord-006229-7yoilsho	955	22	low	low	JJ
cord-006229-7yoilsho	955	23	AA	aa	NN
cord-006229-7yoilsho	955	24	intake	intake	NN
cord-006229-7yoilsho	955	25	day	day	NN
cord-006229-7yoilsho	955	26	(	(	-LRB-
cord-006229-7yoilsho	956	1	0.6	0.6	CD
cord-006229-7yoilsho	956	2	-0.8	-0.8	NN
cord-006229-7yoilsho	956	3	µg	µg	NN
cord-006229-7yoilsho	956	4	/kg	/kg	NNP
cord-006229-7yoilsho	956	5	bw	bw	NNP
cord-006229-7yoilsho	956	6	)	)	-RRB-
cord-006229-7yoilsho	956	7	as	as	RB
cord-006229-7yoilsho	956	8	well	well	RB
cord-006229-7yoilsho	956	9	as	as	IN
cord-006229-7yoilsho	956	10	a	a	DT
cord-006229-7yoilsho	956	11	high	high	JJ
cord-006229-7yoilsho	956	12	AA	aa	NN
cord-006229-7yoilsho	956	13	intake	intake	NN
cord-006229-7yoilsho	956	14	day	day	NN
cord-006229-7yoilsho	956	15	(	(	-LRB-
cord-006229-7yoilsho	956	16	1.3	1.3	CD
cord-006229-7yoilsho	956	17	-1.8	-1.8	CD
cord-006229-7yoilsho	956	18	µg	µg	NN
cord-006229-7yoilsho	956	19	/kg	/kg	NNP
cord-006229-7yoilsho	956	20	bw	bw	NNP
cord-006229-7yoilsho	956	21	)	)	-RRB-
cord-006229-7yoilsho	956	22	.	.	.
cord-006229-7yoilsho	957	1	After	after	IN
cord-006229-7yoilsho	957	2	a	a	DT
cord-006229-7yoilsho	957	3	three	three	CD
cord-006229-7yoilsho	957	4	-	-	HYPH
cord-006229-7yoilsho	957	5	day	day	NN
cord-006229-7yoilsho	957	6	washout	washout	NN
cord-006229-7yoilsho	957	7	period	period	NN
cord-006229-7yoilsho	957	8	an	an	DT
cord-006229-7yoilsho	957	9	AAMA	AAMA	NNP
cord-006229-7yoilsho	957	10	baseline	baseline	JJ
cord-006229-7yoilsho	957	11	level	level	NN
cord-006229-7yoilsho	957	12	of	of	IN
cord-006229-7yoilsho	957	13	93	93	CD
cord-006229-7yoilsho	957	14	±	±	CD
cord-006229-7yoilsho	957	15	31	31	CD
cord-006229-7yoilsho	957	16	nmol	nmol	NN
cord-006229-7yoilsho	957	17	/	/	SYM
cord-006229-7yoilsho	957	18	d	d	NNP
cord-006229-7yoilsho	957	19	was	be	VBD
cord-006229-7yoilsho	957	20	determined	determine	VBN
cord-006229-7yoilsho	957	21	.	.	.
cord-006229-7yoilsho	958	1	Low	low	JJ
cord-006229-7yoilsho	958	2	AA	AA	NNP
cord-006229-7yoilsho	958	3	intake	intake	NN
cord-006229-7yoilsho	958	4	led	lead	VBD
cord-006229-7yoilsho	958	5	to	to	IN
cord-006229-7yoilsho	958	6	an	an	DT
cord-006229-7yoilsho	958	7	AAMA	AAMA	NNP
cord-006229-7yoilsho	958	8	excretion	excretion	NN
cord-006229-7yoilsho	958	9	within	within	IN
cord-006229-7yoilsho	958	10	24	24	CD
cord-006229-7yoilsho	958	11	h	h	NN
cord-006229-7yoilsho	958	12	of	of	IN
cord-006229-7yoilsho	958	13	225	225	CD
cord-006229-7yoilsho	958	14	±	±	CD
cord-006229-7yoilsho	958	15	37	37	CD
cord-006229-7yoilsho	958	16	nmol	nmol	JJ
cord-006229-7yoilsho	958	17	/	/	SYM
cord-006229-7yoilsho	958	18	d	d	NN
cord-006229-7yoilsho	958	19	,	,	,
cord-006229-7yoilsho	958	20	high	high	JJ
cord-006229-7yoilsho	958	21	intake	intake	NN
cord-006229-7yoilsho	958	22	to	to	IN
cord-006229-7yoilsho	958	23	404	404	CD
cord-006229-7yoilsho	958	24	±	±	CD
cord-006229-7yoilsho	958	25	78	78	CD
cord-006229-7yoilsho	959	1	nmol	nmol	NNP
cord-006229-7yoilsho	959	2	/	/	SYM
cord-006229-7yoilsho	959	3	d	d	XX
cord-006229-7yoilsho	959	4	corresponding	correspond	VBG
cord-006229-7yoilsho	959	5	to	to	IN
cord-006229-7yoilsho	959	6	an	an	DT
cord-006229-7yoilsho	959	7	AAMA	AAMA	NNP
cord-006229-7yoilsho	959	8	excretion	excretion	NN
cord-006229-7yoilsho	959	9	rate	rate	NN
cord-006229-7yoilsho	959	10	of	of	IN
cord-006229-7yoilsho	959	11	about	about	RB
cord-006229-7yoilsho	959	12	30	30	CD
cord-006229-7yoilsho	959	13	%	%	NN
cord-006229-7yoilsho	959	14	of	of	IN
cord-006229-7yoilsho	959	15	the	the	DT
cord-006229-7yoilsho	959	16	ingested	ingest	VBN
cord-006229-7yoilsho	959	17	AA	AA	NNP
cord-006229-7yoilsho	959	18	dose	dose	NN
cord-006229-7yoilsho	959	19	within	within	IN
cord-006229-7yoilsho	959	20	24	24	CD
cord-006229-7yoilsho	959	21	h	h	NN
cord-006229-7yoilsho	959	22	,	,	,
cord-006229-7yoilsho	959	23	whereas	whereas	IN
cord-006229-7yoilsho	959	24	AAMA	AAMA	NNP
cord-006229-7yoilsho	959	25	output	output	NN
cord-006229-7yoilsho	959	26	within	within	IN
cord-006229-7yoilsho	959	27	72	72	CD
cord-006229-7yoilsho	959	28	h	h	NN
cord-006229-7yoilsho	959	29	corresponded	correspond	VBD
cord-006229-7yoilsho	959	30	to	to	IN
cord-006229-7yoilsho	959	31	58	58	CD
cord-006229-7yoilsho	959	32	%	%	NN
cord-006229-7yoilsho	959	33	of	of	IN
cord-006229-7yoilsho	959	34	the	the	DT
cord-006229-7yoilsho	959	35	respective	respective	JJ
cord-006229-7yoilsho	959	36	AA	AA	NNP
cord-006229-7yoilsho	959	37	intake	intake	NN
cord-006229-7yoilsho	960	1	,	,	,
cord-006229-7yoilsho	960	2	The	the	DT
cord-006229-7yoilsho	960	3	AAMA	AAMA	NNP
cord-006229-7yoilsho	960	4	baseline	baseline	NN
cord-006229-7yoilsho	960	5	after	after	IN
cord-006229-7yoilsho	960	6	3	3	CD
cord-006229-7yoilsho	960	7	days	day	NNS
cord-006229-7yoilsho	960	8	washout	washout	NN
cord-006229-7yoilsho	960	9	corresponds	correspond	VBZ
cord-006229-7yoilsho	960	10	to	to	IN
cord-006229-7yoilsho	960	11	a	a	DT
cord-006229-7yoilsho	960	12	net	net	JJ
cord-006229-7yoilsho	960	13	exposure	exposure	NN
cord-006229-7yoilsho	960	14	level	level	NN
cord-006229-7yoilsho	960	15	of	of	IN
cord-006229-7yoilsho	960	16	0.2	0.2	CD
cord-006229-7yoilsho	960	17	-0.3	-0.3	CD
cord-006229-7yoilsho	960	18	μg	μg	NN
cord-006229-7yoilsho	960	19	AA	AA	NNP
cord-006229-7yoilsho	960	20	/	/	SYM
cord-006229-7yoilsho	960	21	kg	kg	NNP
cord-006229-7yoilsho	960	22	bw	bw	NNP
cord-006229-7yoilsho	960	23	/	/	SYM
cord-006229-7yoilsho	960	24	d	d	NNP
cord-006229-7yoilsho	960	25	.	.	.
cord-006229-7yoilsho	961	1	Whether	whether	IN
cord-006229-7yoilsho	961	2	this	this	DT
cord-006229-7yoilsho	961	3	represents	represent	VBZ
cord-006229-7yoilsho	961	4	a	a	DT
cord-006229-7yoilsho	961	5	true	true	JJ
cord-006229-7yoilsho	961	6	baseline	baseline	JJ
cord-006229-7yoilsho	961	7	level	level	NN
cord-006229-7yoilsho	961	8	is	be	VBZ
cord-006229-7yoilsho	961	9	to	to	TO
cord-006229-7yoilsho	961	10	be	be	VB
cord-006229-7yoilsho	961	11	clarified	clarify	VBN
cord-006229-7yoilsho	961	12	in	in	IN
cord-006229-7yoilsho	961	13	a	a	DT
cord-006229-7yoilsho	961	14	follow	follow	VB
cord-006229-7yoilsho	961	15	-	-	HYPH
cord-006229-7yoilsho	961	16	up	up	NN
cord-006229-7yoilsho	961	17	study	study	NN
cord-006229-7yoilsho	961	18	.	.	.
cord-006229-7yoilsho	962	1	In	in	IN
cord-006229-7yoilsho	962	2	summary	summary	NN
cord-006229-7yoilsho	962	3	,	,	,
cord-006229-7yoilsho	962	4	this	this	DT
cord-006229-7yoilsho	962	5	study	study	NN
cord-006229-7yoilsho	962	6	provides	provide	VBZ
cord-006229-7yoilsho	962	7	important	important	JJ
cord-006229-7yoilsho	962	8	quantitative	quantitative	JJ
cord-006229-7yoilsho	962	9	information	information	NN
cord-006229-7yoilsho	962	10	on	on	IN
cord-006229-7yoilsho	962	11	kinetics	kinetic	NNS
cord-006229-7yoilsho	962	12	of	of	IN
cord-006229-7yoilsho	962	13	urinary	urinary	JJ
cord-006229-7yoilsho	962	14	short	short	JJ
cord-006229-7yoilsho	962	15	-	-	HYPH
cord-006229-7yoilsho	962	16	term	term	NN
cord-006229-7yoilsho	962	17	exposure	exposure	NN
cord-006229-7yoilsho	962	18	biomarkers	biomarker	NNS
cord-006229-7yoilsho	962	19	validated	validate	VBN
cord-006229-7yoilsho	962	20	by	by	IN
cord-006229-7yoilsho	962	21	analytically	analytically	RB
cord-006229-7yoilsho	962	22	verified	verify	VBN
cord-006229-7yoilsho	962	23	dietary	dietary	JJ
cord-006229-7yoilsho	962	24	AA	AA	NNP
cord-006229-7yoilsho	962	25	intake	intake	NN
cord-006229-7yoilsho	962	26	at	at	IN
cord-006229-7yoilsho	962	27	present	present	JJ
cord-006229-7yoilsho	962	28	day	day	NN
cord-006229-7yoilsho	962	29	food	food	NN
cord-006229-7yoilsho	962	30	contamination	contamination	NN
cord-006229-7yoilsho	962	31	levels	level	NNS
cord-006229-7yoilsho	962	32	.	.	.
cord-006229-7yoilsho	963	1	[	[	-LRB-
cord-006229-7yoilsho	963	2	1	1	CD
cord-006229-7yoilsho	963	3	]	]	-RRB-
cord-006229-7yoilsho	963	4	Deutsche	Deutsche	NNP
cord-006229-7yoilsho	963	5	Forschungsgemeinschaft	Forschungsgemeinschaft	NNP
cord-006229-7yoilsho	963	6	(	(	-LRB-
cord-006229-7yoilsho	963	7	DFG	DFG	NNP
cord-006229-7yoilsho	963	8	)	)	-RRB-
cord-006229-7yoilsho	963	9	,	,	,
cord-006229-7yoilsho	963	10	MAK	MAK	NNP
cord-006229-7yoilsho	963	11	-	-	HYPH
cord-006229-7yoilsho	963	12	und	und	NNP
cord-006229-7yoilsho	963	13	BAT	BAT	NNP
cord-006229-7yoilsho	963	14	-	-	HYPH
cord-006229-7yoilsho	963	15	Werte	Werte	NNP
cord-006229-7yoilsho	963	16	-	-	HYPH
cord-006229-7yoilsho	963	17	Liste	Liste	NNP
cord-006229-7yoilsho	963	18	2013	2013	CD
cord-006229-7yoilsho	963	19	,	,	,
cord-006229-7yoilsho	963	20	2013	2013	CD
cord-006229-7yoilsho	963	21	DOI	doi	NN
cord-006229-7yoilsho	963	22	:	:	:
cord-006229-7yoilsho	963	23	10.1002	10.1002	CD
cord-006229-7yoilsho	963	24	IARC	IARC	NNP
cord-006229-7yoilsho	963	25	,	,	,
cord-006229-7yoilsho	963	26	IARC	IARC	NNP
cord-006229-7yoilsho	963	27	Monographs	Monographs	NNPS
cord-006229-7yoilsho	963	28	on	on	IN
cord-006229-7yoilsho	963	29	the	the	DT
cord-006229-7yoilsho	963	30	Evaluations	evaluation	NNS
cord-006229-7yoilsho	963	31	of	of	IN
cord-006229-7yoilsho	963	32	Carcinogenic	carcinogenic	JJ
cord-006229-7yoilsho	963	33	Risks	risk	NNS
cord-006229-7yoilsho	963	34	to	to	IN
cord-006229-7yoilsho	963	35	Humans	human	NNS
cord-006229-7yoilsho	963	36	1994	1994	CD
cord-006229-7yoilsho	963	37	,	,	,
cord-006229-7yoilsho	963	38	60	60	CD
cord-006229-7yoilsho	963	39	.	.	.
cord-006229-7yoilsho	964	1	[	[	-LRB-
cord-006229-7yoilsho	964	2	3	3	LS
cord-006229-7yoilsho	964	3	]	]	-RRB-
cord-006229-7yoilsho	964	4	Tareke	Tareke	NNP
cord-006229-7yoilsho	964	5	et	et	FW
cord-006229-7yoilsho	964	6	al	al	NNP
cord-006229-7yoilsho	964	7	.	.	.
cord-006229-7yoilsho	965	1	,	,	,
cord-006229-7yoilsho	965	2	J.	J.	NNP
cord-006229-7yoilsho	965	3	Agric	Agric	NNP
cord-006229-7yoilsho	965	4	.	.	.
cord-006229-7yoilsho	966	1	Food	Food	NNP
cord-006229-7yoilsho	966	2	Chem	Chem	NNP
cord-006229-7yoilsho	966	3	.	.	.
cord-006229-7yoilsho	967	1	2002	2002	CD
cord-006229-7yoilsho	967	2	,	,	,
cord-006229-7yoilsho	967	3	50	50	CD
cord-006229-7yoilsho	967	4	,	,	,
cord-006229-7yoilsho	967	5	4998	4998	CD
cord-006229-7yoilsho	967	6	-	-	SYM
cord-006229-7yoilsho	967	7	5006	5006	CD
cord-006229-7yoilsho	967	8	.	.	.
cord-006229-7yoilsho	968	1	[	[	-LRB-
cord-006229-7yoilsho	968	2	4	4	CD
cord-006229-7yoilsho	968	3	]	]	-RRB-
cord-006229-7yoilsho	968	4	EFSA	EFSA	NNP
cord-006229-7yoilsho	968	5	Panel	Panel	NNP
cord-006229-7yoilsho	968	6	on	on	IN
cord-006229-7yoilsho	968	7	Contaminants	Contaminants	NNPS
cord-006229-7yoilsho	968	8	in	in	IN
cord-006229-7yoilsho	968	9	the	the	DT
cord-006229-7yoilsho	968	10	Food	Food	NNP
cord-006229-7yoilsho	968	11	Chain	Chain	NNP
cord-006229-7yoilsho	968	12	(	(	-LRB-
cord-006229-7yoilsho	968	13	CONTAM	CONTAM	NNP
cord-006229-7yoilsho	968	14	)	)	-RRB-
cord-006229-7yoilsho	968	15	,	,	,
cord-006229-7yoilsho	968	16	EFSA	EFSA	NNP
cord-006229-7yoilsho	968	17	Journal	Journal	NNP
cord-006229-7yoilsho	968	18	2015	2015	CD
cord-006229-7yoilsho	968	19	;	;	:
cord-006229-7yoilsho	968	20	13(6):4104	13(6):4104	NNP
cord-006229-7yoilsho	968	21	[	[	-LRB-
cord-006229-7yoilsho	968	22	321	321	CD
cord-006229-7yoilsho	968	23	pp	pp	NN
cord-006229-7yoilsho	968	24	.	.	.
cord-006229-7yoilsho	968	25	]	]	-RRB-
cord-006229-7yoilsho	968	26	.	.	.
cord-006229-7yoilsho	969	1	[	[	-LRB-
cord-006229-7yoilsho	969	2	5	5	CD
cord-006229-7yoilsho	969	3	]	]	-RRB-
cord-006229-7yoilsho	970	1	Ruenz	Ruenz	NNP
cord-006229-7yoilsho	970	2	et	et	NNP
cord-006229-7yoilsho	970	3	al	al	NNP
cord-006229-7yoilsho	970	4	.	.	.
cord-006229-7yoilsho	971	1	,	,	,
cord-006229-7yoilsho	971	2	Arch	Arch	NNP
cord-006229-7yoilsho	971	3	.	.	.
cord-006229-7yoilsho	972	1	Toxicol	Toxicol	NNP
cord-006229-7yoilsho	972	2	.	.	.
cord-006229-7yoilsho	973	1	2015	2015	CD
cord-006229-7yoilsho	973	2	DOI	doi	NN
cord-006229-7yoilsho	973	3	:	:	:
cord-006229-7yoilsho	974	1	10.1007	10.1007	CD
cord-006229-7yoilsho	974	2	/s00204	/s00204	NNPS
cord-006229-7yoilsho	974	3	-	-	:
cord-006229-7yoilsho	974	4	015	015	CD
cord-006229-7yoilsho	975	1	-1494	-1494	:
cord-006229-7yoilsho	975	2	Heinrich	Heinrich	NNP
cord-006229-7yoilsho	975	3	-	-	HYPH
cord-006229-7yoilsho	975	4	Heine	Heine	NNP
cord-006229-7yoilsho	975	5	-	-	HYPH
cord-006229-7yoilsho	975	6	Universität	Universität	NNP
cord-006229-7yoilsho	975	7	,	,	,
cord-006229-7yoilsho	975	8	Institut	Institut	NNP
cord-006229-7yoilsho	975	9	für	für	IN
cord-006229-7yoilsho	975	10	Toxikologie	Toxikologie	NNP
cord-006229-7yoilsho	975	11	,	,	,
cord-006229-7yoilsho	975	12	Düsseldorf	Düsseldorf	NNP
cord-006229-7yoilsho	975	13	,	,	,
cord-006229-7yoilsho	976	1	Germany	Germany	NNP
cord-006229-7yoilsho	976	2	Objective	Objective	NNP
cord-006229-7yoilsho	977	1	:	:	:
cord-006229-7yoilsho	977	2	Flavonoids	Flavonoids	NNP
cord-006229-7yoilsho	977	3	are	be	VBP
cord-006229-7yoilsho	977	4	known	know	VBN
cord-006229-7yoilsho	977	5	to	to	TO
cord-006229-7yoilsho	977	6	modulate	modulate	VB
cord-006229-7yoilsho	977	7	distinct	distinct	JJ
cord-006229-7yoilsho	977	8	signaling	signal	VBG
cord-006229-7yoilsho	977	9	pathways	pathway	NNS
cord-006229-7yoilsho	977	10	thereby	thereby	RB
cord-006229-7yoilsho	977	11	causing	cause	VBG
cord-006229-7yoilsho	977	12	different	different	JJ
cord-006229-7yoilsho	977	13	physiological	physiological	JJ
cord-006229-7yoilsho	977	14	effects	effect	NNS
cord-006229-7yoilsho	977	15	.	.	.
cord-006229-7yoilsho	978	1	Effects	effect	NNS
cord-006229-7yoilsho	978	2	of	of	IN
cord-006229-7yoilsho	978	3	the	the	DT
cord-006229-7yoilsho	978	4	flavonoids	flavonoid	NNS
cord-006229-7yoilsho	978	5	baicalein	baicalein	NNP
cord-006229-7yoilsho	978	6	and	and	CC
cord-006229-7yoilsho	978	7	myricetin	myricetin	NNP
cord-006229-7yoilsho	978	8	as	as	RB
cord-006229-7yoilsho	978	9	well	well	RB
cord-006229-7yoilsho	978	10	as	as	IN
cord-006229-7yoilsho	978	11	several	several	JJ
cord-006229-7yoilsho	978	12	methylated	methylate	VBN
cord-006229-7yoilsho	978	13	derivatives	derivative	NNS
cord-006229-7yoilsho	978	14	were	be	VBD
cord-006229-7yoilsho	978	15	analyzed	analyze	VBN
cord-006229-7yoilsho	978	16	in	in	IN
cord-006229-7yoilsho	978	17	the	the	DT
cord-006229-7yoilsho	978	18	nematode	nematode	NN
cord-006229-7yoilsho	978	19	Caenorhabditis	Caenorhabditis	NNP
cord-006229-7yoilsho	978	20	elegans	elegan	NNS
cord-006229-7yoilsho	978	21	and	and	CC
cord-006229-7yoilsho	978	22	in	in	RB
cord-006229-7yoilsho	978	23	in	in	IN
cord-006229-7yoilsho	978	24	Hct116	hct116	JJ
cord-006229-7yoilsho	978	25	colon	colon	NN
cord-006229-7yoilsho	978	26	carcinoma	carcinoma	NN
cord-006229-7yoilsho	978	27	cells	cell	NNS
cord-006229-7yoilsho	978	28	and	and	CC
cord-006229-7yoilsho	978	29	to	to	TO
cord-006229-7yoilsho	978	30	get	get	VB
cord-006229-7yoilsho	978	31	insights	insight	NNS
cord-006229-7yoilsho	978	32	in	in	IN
cord-006229-7yoilsho	978	33	molecular	molecular	JJ
cord-006229-7yoilsho	978	34	mechanisms	mechanism	NNS
cord-006229-7yoilsho	978	35	modulated	modulate	VBN
cord-006229-7yoilsho	978	36	by	by	IN
cord-006229-7yoilsho	978	37	these	these	DT
cord-006229-7yoilsho	978	38	compounds	compound	NNS
cord-006229-7yoilsho	978	39	.	.	.
cord-006229-7yoilsho	979	1	Methods	method	NNS
cord-006229-7yoilsho	979	2	:	:	:
cord-006229-7yoilsho	979	3	radical	radical	JJ
cord-006229-7yoilsho	979	4	-	-	HYPH
cord-006229-7yoilsho	979	5	scavenging	scavenging	NN
cord-006229-7yoilsho	979	6	activity	activity	NN
cord-006229-7yoilsho	979	7	(	(	-LRB-
cord-006229-7yoilsho	979	8	TEAC	TEAC	NNP
cord-006229-7yoilsho	979	9	,	,	,
cord-006229-7yoilsho	979	10	DCF	DCF	NNP
cord-006229-7yoilsho	979	11	)	)	-RRB-
cord-006229-7yoilsho	979	12	,	,	,
cord-006229-7yoilsho	979	13	stress	stress	NN
cord-006229-7yoilsho	979	14	resistance	resistance	NN
cord-006229-7yoilsho	979	15	(	(	-LRB-
cord-006229-7yoilsho	979	16	SYTOX	SYTOX	NNP
cord-006229-7yoilsho	979	17	,	,	,
cord-006229-7yoilsho	979	18	sodium	sodium	NN
cord-006229-7yoilsho	979	19	arsenite	arsenite	JJ
cord-006229-7yoilsho	979	20	)	)	-RRB-
cord-006229-7yoilsho	979	21	,	,	,
cord-006229-7yoilsho	979	22	modulation	modulation	NN
cord-006229-7yoilsho	979	23	of	of	IN
cord-006229-7yoilsho	979	24	signaling	signal	VBG
cord-006229-7yoilsho	979	25	pathways	pathway	NNS
cord-006229-7yoilsho	979	26	(	(	-LRB-
cord-006229-7yoilsho	979	27	Nrf2	Nrf2	NNP
cord-006229-7yoilsho	979	28	/	/	SYM
cord-006229-7yoilsho	979	29	SKN-1	SKN-1	NNP
cord-006229-7yoilsho	979	30	,	,	,
cord-006229-7yoilsho	979	31	DAF16	DAF16	NNP
cord-006229-7yoilsho	979	32	)	)	-RRB-
cord-006229-7yoilsho	979	33	,	,	,
cord-006229-7yoilsho	979	34	life	life	NN
cord-006229-7yoilsho	979	35	span	span	NN
cord-006229-7yoilsho	979	36	.	.	.
cord-006229-7yoilsho	980	1	Results	result	NNS
cord-006229-7yoilsho	980	2	:	:	:
cord-006229-7yoilsho	981	1	Baicalein	Baicalein	NNP
cord-006229-7yoilsho	981	2	enhances	enhance	VBZ
cord-006229-7yoilsho	981	3	the	the	DT
cord-006229-7yoilsho	981	4	resistance	resistance	NN
cord-006229-7yoilsho	981	5	of	of	IN
cord-006229-7yoilsho	981	6	C.	C.	NNP
cord-006229-7yoilsho	981	7	elegans	elegan	NNS
cord-006229-7yoilsho	981	8	against	against	IN
cord-006229-7yoilsho	981	9	lethal	lethal	JJ
cord-006229-7yoilsho	981	10	thermal	thermal	JJ
cord-006229-7yoilsho	981	11	and	and	CC
cord-006229-7yoilsho	981	12	sodium	sodium	NN
cord-006229-7yoilsho	981	13	arsenite	arsenite	JJ
cord-006229-7yoilsho	981	14	stress	stress	NN
cord-006229-7yoilsho	981	15	and	and	CC
cord-006229-7yoilsho	981	16	dose	dose	NN
cord-006229-7yoilsho	981	17	-	-	HYPH
cord-006229-7yoilsho	981	18	dependently	dependently	RB
cord-006229-7yoilsho	981	19	prolongs	prolong	VBZ
cord-006229-7yoilsho	981	20	the	the	DT
cord-006229-7yoilsho	981	21	life	life	NN
cord-006229-7yoilsho	981	22	span	span	NN
cord-006229-7yoilsho	981	23	of	of	IN
cord-006229-7yoilsho	981	24	the	the	DT
cord-006229-7yoilsho	981	25	nematode	nematode	NN
cord-006229-7yoilsho	981	26	(	(	-LRB-
cord-006229-7yoilsho	981	27	median	median	JJ
cord-006229-7yoilsho	981	28	life	life	NN
cord-006229-7yoilsho	981	29	span	span	NN
cord-006229-7yoilsho	981	30	:	:	:
cord-006229-7yoilsho	981	31	+	+	SYM
cord-006229-7yoilsho	981	32	57	57	CD
cord-006229-7yoilsho	981	33	%	%	NN
cord-006229-7yoilsho	981	34	)	)	-RRB-
cord-006229-7yoilsho	981	35	.	.	.
cord-006229-7yoilsho	982	1	Using	use	VBG
cord-006229-7yoilsho	982	2	RNA	RNA	NNP
cord-006229-7yoilsho	982	3	interference	interference	NN
cord-006229-7yoilsho	982	4	we	-PRON-	PRP
cord-006229-7yoilsho	982	5	were	be	VBD
cord-006229-7yoilsho	982	6	able	able	JJ
cord-006229-7yoilsho	982	7	to	to	TO
cord-006229-7yoilsho	982	8	show	show	VB
cord-006229-7yoilsho	982	9	that	that	IN
cord-006229-7yoilsho	982	10	the	the	DT
cord-006229-7yoilsho	982	11	induction	induction	NN
cord-006229-7yoilsho	982	12	of	of	IN
cord-006229-7yoilsho	982	13	longevity	longevity	NN
cord-006229-7yoilsho	982	14	and	and	CC
cord-006229-7yoilsho	982	15	the	the	DT
cord-006229-7yoilsho	982	16	enhanced	enhance	VBN
cord-006229-7yoilsho	982	17	stress	stress	NN
cord-006229-7yoilsho	982	18	-	-	HYPH
cord-006229-7yoilsho	982	19	resistance	resistance	NN
cord-006229-7yoilsho	982	20	were	be	VBD
cord-006229-7yoilsho	982	21	dependent	dependent	JJ
cord-006229-7yoilsho	982	22	on	on	IN
cord-006229-7yoilsho	982	23	SKN-1	SKN-1	NNP
cord-006229-7yoilsho	983	1	(	(	-LRB-
cord-006229-7yoilsho	983	2	homolog	homolog	NN
cord-006229-7yoilsho	983	3	to	to	IN
cord-006229-7yoilsho	983	4	mammalian	mammalian	JJ
cord-006229-7yoilsho	983	5	Nrf2	Nrf2	NNP
cord-006229-7yoilsho	983	6	)	)	-RRB-
cord-006229-7yoilsho	983	7	,	,	,
cord-006229-7yoilsho	983	8	but	but	CC
cord-006229-7yoilsho	983	9	not	not	RB
cord-006229-7yoilsho	983	10	DAF-16	DAF-16	NNP
cord-006229-7yoilsho	984	1	(	(	-LRB-
cord-006229-7yoilsho	984	2	homolog	homolog	NN
cord-006229-7yoilsho	984	3	to	to	IN
cord-006229-7yoilsho	984	4	mammalian	mammalian	JJ
cord-006229-7yoilsho	984	5	FOXO	FOXO	NNP
cord-006229-7yoilsho	984	6	)	)	-RRB-
cord-006229-7yoilsho	984	7	,	,	,
cord-006229-7yoilsho	984	8	another	another	DT
cord-006229-7yoilsho	984	9	pivotal	pivotal	JJ
cord-006229-7yoilsho	984	10	transcription	transcription	NN
cord-006229-7yoilsho	984	11	factor	factor	NN
cord-006229-7yoilsho	984	12	.	.	.
cord-006229-7yoilsho	985	1	Negletein	Negletein	NNP
cord-006229-7yoilsho	985	2	was	be	VBD
cord-006229-7yoilsho	985	3	the	the	DT
cord-006229-7yoilsho	985	4	only	only	RB
cord-006229-7yoilsho	985	5	methylated	methylated	JJ
cord-006229-7yoilsho	985	6	derivative	derivative	NN
cord-006229-7yoilsho	985	7	which	which	WDT
cord-006229-7yoilsho	985	8	was	be	VBD
cord-006229-7yoilsho	985	9	able	able	JJ
cord-006229-7yoilsho	985	10	to	to	TO
cord-006229-7yoilsho	985	11	enhance	enhance	VB
cord-006229-7yoilsho	985	12	the	the	DT
cord-006229-7yoilsho	985	13	life	life	NN
cord-006229-7yoilsho	985	14	span	span	NN
cord-006229-7yoilsho	985	15	of	of	IN
cord-006229-7yoilsho	985	16	the	the	DT
cord-006229-7yoilsho	985	17	nematode	nematode	NN
cord-006229-7yoilsho	985	18	.	.	.
cord-006229-7yoilsho	986	1	In	in	IN
cord-006229-7yoilsho	986	2	Hct116	hct116	JJ
cord-006229-7yoilsho	986	3	cells	cell	NNS
cord-006229-7yoilsho	986	4	,	,	,
cord-006229-7yoilsho	986	5	baicalein	baicalein	NNP
cord-006229-7yoilsho	986	6	activates	activate	VBZ
cord-006229-7yoilsho	986	7	Nrf2	Nrf2	NNP
cord-006229-7yoilsho	986	8	;	;	:
cord-006229-7yoilsho	986	9	the	the	DT
cord-006229-7yoilsho	986	10	methylated	methylate	VBN
cord-006229-7yoilsho	986	11	derivatives	derivative	NNS
cord-006229-7yoilsho	986	12	oroxylin	oroxylin	NNP
cord-006229-7yoilsho	986	13	A	A	NNP
cord-006229-7yoilsho	986	14	and	and	CC
cord-006229-7yoilsho	986	15	negletein	negletein	NNP
cord-006229-7yoilsho	986	16	showed	show	VBD
cord-006229-7yoilsho	986	17	a	a	DT
cord-006229-7yoilsho	986	18	comparable	comparable	JJ
cord-006229-7yoilsho	986	19	redox	redox	NN
cord-006229-7yoilsho	986	20	-	-	HYPH
cord-006229-7yoilsho	986	21	active	active	JJ
cord-006229-7yoilsho	986	22	potential	potential	NN
cord-006229-7yoilsho	986	23	in	in	IN
cord-006229-7yoilsho	986	24	these	these	DT
cord-006229-7yoilsho	986	25	cells	cell	NNS
cord-006229-7yoilsho	986	26	,	,	,
cord-006229-7yoilsho	986	27	but	but	CC
cord-006229-7yoilsho	986	28	only	only	RB
cord-006229-7yoilsho	986	29	negletein	negletein	NNP
cord-006229-7yoilsho	986	30	was	be	VBD
cord-006229-7yoilsho	986	31	able	able	JJ
cord-006229-7yoilsho	986	32	to	to	TO
cord-006229-7yoilsho	986	33	activate	activate	VB
cord-006229-7yoilsho	986	34	Nrf2	Nrf2	NNP
cord-006229-7yoilsho	986	35	.	.	.
cord-006229-7yoilsho	987	1	The	the	DT
cord-006229-7yoilsho	987	2	dietary	dietary	JJ
cord-006229-7yoilsho	987	3	flavonoid	flavonoid	NN
cord-006229-7yoilsho	987	4	myricetin	myricetin	NNS
cord-006229-7yoilsho	987	5	as	as	RB
cord-006229-7yoilsho	987	6	well	well	RB
cord-006229-7yoilsho	987	7	as	as	IN
cord-006229-7yoilsho	987	8	the	the	DT
cord-006229-7yoilsho	987	9	methylated	methylated	JJ
cord-006229-7yoilsho	987	10	derivatives	derivative	NNS
cord-006229-7yoilsho	987	11	laricitrin	laricitrin	NNP
cord-006229-7yoilsho	987	12	,	,	,
cord-006229-7yoilsho	987	13	syringetin	syringetin	NNP
cord-006229-7yoilsho	987	14	and	and	CC
cord-006229-7yoilsho	987	15	myricetintrimethylether	myricetintrimethylether	NNP
cord-006229-7yoilsho	987	16	strongly	strongly	RB
cord-006229-7yoilsho	987	17	enhance	enhance	VBP
cord-006229-7yoilsho	987	18	life	life	NN
cord-006229-7yoilsho	987	19	span	span	NN
cord-006229-7yoilsho	987	20	of	of	IN
cord-006229-7yoilsho	987	21	C.	C.	NNP
cord-006229-7yoilsho	987	22	elegans	elegan	NNS
cord-006229-7yoilsho	987	23	,	,	,
cord-006229-7yoilsho	987	24	decreased	decrease	VBD
cord-006229-7yoilsho	987	25	oxidative	oxidative	JJ
cord-006229-7yoilsho	987	26	stress	stress	NN
cord-006229-7yoilsho	987	27	(	(	-LRB-
cord-006229-7yoilsho	987	28	DCF	DCF	NNP
cord-006229-7yoilsho	987	29	)	)	-RRB-
cord-006229-7yoilsho	987	30	and	and	CC
cord-006229-7yoilsho	987	31	accumulation	accumulation	NN
cord-006229-7yoilsho	987	32	of	of	IN
cord-006229-7yoilsho	987	33	lipofuscin	lipofuscin	NNS
cord-006229-7yoilsho	987	34	.	.	.
cord-006229-7yoilsho	988	1	In	in	IN
cord-006229-7yoilsho	988	2	contrast	contrast	NN
cord-006229-7yoilsho	988	3	to	to	IN
cord-006229-7yoilsho	988	4	myricetin	myricetin	NNP
cord-006229-7yoilsho	988	5	,	,	,
cord-006229-7yoilsho	988	6	the	the	DT
cord-006229-7yoilsho	988	7	methylated	methylated	JJ
cord-006229-7yoilsho	988	8	compounds	compound	NNS
cord-006229-7yoilsho	988	9	strongly	strongly	RB
cord-006229-7yoilsho	988	10	enhanced	enhance	VBD
cord-006229-7yoilsho	988	11	the	the	DT
cord-006229-7yoilsho	988	12	resistance	resistance	NN
cord-006229-7yoilsho	988	13	against	against	IN
cord-006229-7yoilsho	988	14	thermal	thermal	JJ
cord-006229-7yoilsho	988	15	stress	stress	NN
cord-006229-7yoilsho	988	16	.	.	.
cord-006229-7yoilsho	989	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	989	2	,	,	,
cord-006229-7yoilsho	989	3	treatment	treatment	NN
cord-006229-7yoilsho	989	4	with	with	IN
cord-006229-7yoilsho	989	5	the	the	DT
cord-006229-7yoilsho	989	6	derivatives	derivative	NNS
cord-006229-7yoilsho	989	7	induced	induce	VBN
cord-006229-7yoilsho	989	8	a	a	DT
cord-006229-7yoilsho	989	9	much	much	RB
cord-006229-7yoilsho	989	10	stronger	strong	JJR
cord-006229-7yoilsho	989	11	nuclear	nuclear	JJ
cord-006229-7yoilsho	989	12	localization	localization	NN
cord-006229-7yoilsho	989	13	of	of	IN
cord-006229-7yoilsho	989	14	the	the	DT
cord-006229-7yoilsho	989	15	DAF-16	DAF-16	NNP
cord-006229-7yoilsho	989	16	transcription	transcription	NN
cord-006229-7yoilsho	989	17	factor	factor	NN
cord-006229-7yoilsho	989	18	.	.	.
cord-006229-7yoilsho	990	1	Conclusion	conclusion	NN
cord-006229-7yoilsho	990	2	:	:	:
cord-006229-7yoilsho	991	1	Baicalein	Baicalein	NNP
cord-006229-7yoilsho	991	2	increases	increase	VBZ
cord-006229-7yoilsho	991	3	stress	stress	NN
cord-006229-7yoilsho	991	4	-	-	HYPH
cord-006229-7yoilsho	991	5	resistance	resistance	NN
cord-006229-7yoilsho	991	6	and	and	CC
cord-006229-7yoilsho	991	7	life	life	NN
cord-006229-7yoilsho	991	8	span	span	NN
cord-006229-7yoilsho	991	9	in	in	IN
cord-006229-7yoilsho	991	10	C.	C.	NNP
cord-006229-7yoilsho	991	11	elegans	elegan	NNS
cord-006229-7yoilsho	991	12	via	via	IN
cord-006229-7yoilsho	991	13	SKN-1	SKN-1	NNP
cord-006229-7yoilsho	991	14	but	but	CC
cord-006229-7yoilsho	991	15	not	not	RB
cord-006229-7yoilsho	991	16	DAF-16	DAF-16	NNP
cord-006229-7yoilsho	991	17	.	.	.
cord-006229-7yoilsho	992	1	Experiments	experiment	NNS
cord-006229-7yoilsho	992	2	with	with	IN
cord-006229-7yoilsho	992	3	methylated	methylated	JJ
cord-006229-7yoilsho	992	4	baicalein	baicalein	NNP
cord-006229-7yoilsho	992	5	derivatives	derivative	NNS
cord-006229-7yoilsho	992	6	suggest	suggest	VBP
cord-006229-7yoilsho	992	7	that	that	IN
cord-006229-7yoilsho	992	8	the	the	DT
cord-006229-7yoilsho	992	9	redox	redox	NN
cord-006229-7yoilsho	992	10	-	-	HYPH
cord-006229-7yoilsho	992	11	active	active	JJ
cord-006229-7yoilsho	992	12	potential	potential	NN
cord-006229-7yoilsho	992	13	has	have	VBZ
cord-006229-7yoilsho	992	14	a	a	DT
cord-006229-7yoilsho	992	15	minor	minor	JJ
cord-006229-7yoilsho	992	16	impact	impact	NN
cord-006229-7yoilsho	992	17	on	on	IN
cord-006229-7yoilsho	992	18	the	the	DT
cord-006229-7yoilsho	992	19	Nrf2	Nrf2	NNP
cord-006229-7yoilsho	992	20	/	/	SYM
cord-006229-7yoilsho	992	21	SKN-1	SKN-1	NNP
cord-006229-7yoilsho	992	22	activation	activation	NN
cord-006229-7yoilsho	992	23	since	since	IN
cord-006229-7yoilsho	992	24	only	only	RB
cord-006229-7yoilsho	992	25	distinct	distinct	JJ
cord-006229-7yoilsho	992	26	derivates	derivate	NNS
cord-006229-7yoilsho	992	27	activate	activate	VBP
cord-006229-7yoilsho	992	28	this	this	DT
cord-006229-7yoilsho	992	29	pathway	pathway	NN
cord-006229-7yoilsho	992	30	.	.	.
cord-006229-7yoilsho	993	1	In	in	IN
cord-006229-7yoilsho	993	2	case	case	NN
cord-006229-7yoilsho	993	3	of	of	IN
cord-006229-7yoilsho	993	4	myricetin	myricetin	NNP
cord-006229-7yoilsho	993	5	,	,	,
cord-006229-7yoilsho	993	6	the	the	DT
cord-006229-7yoilsho	993	7	methylation	methylation	NN
cord-006229-7yoilsho	993	8	increases	increase	VBZ
cord-006229-7yoilsho	993	9	the	the	DT
cord-006229-7yoilsho	993	10	stress	stress	NN
cord-006229-7yoilsho	993	11	resistance	resistance	NN
cord-006229-7yoilsho	993	12	of	of	IN
cord-006229-7yoilsho	993	13	the	the	DT
cord-006229-7yoilsho	993	14	flavonoid	flavonoid	NN
cord-006229-7yoilsho	993	15	.	.	.
cord-006229-7yoilsho	994	1	Methylation	Methylation	NNP
cord-006229-7yoilsho	994	2	seems	seem	VBZ
cord-006229-7yoilsho	994	3	to	to	TO
cord-006229-7yoilsho	994	4	enhance	enhance	VB
cord-006229-7yoilsho	994	5	the	the	DT
cord-006229-7yoilsho	994	6	biofunctionality	biofunctionality	NN
cord-006229-7yoilsho	994	7	of	of	IN
cord-006229-7yoilsho	994	8	the	the	DT
cord-006229-7yoilsho	994	9	flavonoids	flavonoid	NNS
cord-006229-7yoilsho	994	10	.	.	.
cord-006229-7yoilsho	995	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	995	2	results	result	NNS
cord-006229-7yoilsho	995	3	may	may	MD
cord-006229-7yoilsho	995	4	be	be	VB
cord-006229-7yoilsho	995	5	useful	useful	JJ
cord-006229-7yoilsho	995	6	to	to	TO
cord-006229-7yoilsho	995	7	understand	understand	VB
cord-006229-7yoilsho	995	8	molecular	molecular	JJ
cord-006229-7yoilsho	995	9	mechanisms	mechanism	NNS
cord-006229-7yoilsho	995	10	of	of	IN
cord-006229-7yoilsho	995	11	flavonoids	flavonoid	NNS
cord-006229-7yoilsho	995	12	and	and	CC
cord-006229-7yoilsho	995	13	methylated	methylate	VBN
cord-006229-7yoilsho	995	14	derivatives	derivative	NNS
cord-006229-7yoilsho	995	15	used	use	VBN
cord-006229-7yoilsho	995	16	as	as	IN
cord-006229-7yoilsho	995	17	food	food	NN
cord-006229-7yoilsho	995	18	supplements	supplement	NNS
cord-006229-7yoilsho	995	19	or	or	CC
cord-006229-7yoilsho	995	20	pharmacological	pharmacological	JJ
cord-006229-7yoilsho	995	21	extracts	extract	NNS
cord-006229-7yoilsho	995	22	.	.	.
cord-006229-7yoilsho	996	1	The	the	DT
cord-006229-7yoilsho	996	2	loss	loss	NN
cord-006229-7yoilsho	996	3	of	of	IN
cord-006229-7yoilsho	996	4	progesterone	progesterone	NN
cord-006229-7yoilsho	996	5	during	during	IN
cord-006229-7yoilsho	996	6	menopause	menopause	NN
cord-006229-7yoilsho	996	7	is	be	VBZ
cord-006229-7yoilsho	996	8	linked	link	VBN
cord-006229-7yoilsho	996	9	to	to	IN
cord-006229-7yoilsho	996	10	common	common	JJ
cord-006229-7yoilsho	996	11	sleep	sleep	NN
cord-006229-7yoilsho	996	12	complaints	complaint	NNS
cord-006229-7yoilsho	996	13	of	of	IN
cord-006229-7yoilsho	996	14	the	the	DT
cord-006229-7yoilsho	996	15	affected	affected	JJ
cord-006229-7yoilsho	996	16	women	woman	NNS
cord-006229-7yoilsho	996	17	.	.	.
cord-006229-7yoilsho	997	1	Consequently	consequently	RB
cord-006229-7yoilsho	997	2	,	,	,
cord-006229-7yoilsho	997	3	a	a	DT
cord-006229-7yoilsho	997	4	previous	previous	JJ
cord-006229-7yoilsho	997	5	study	study	NN
cord-006229-7yoilsho	997	6	of	of	IN
cord-006229-7yoilsho	997	7	our	-PRON-	PRP$
cord-006229-7yoilsho	997	8	laboratory	laboratory	NN
cord-006229-7yoilsho	997	9	demonstrated	demonstrate	VBD
cord-006229-7yoilsho	997	10	sleep	sleep	NN
cord-006229-7yoilsho	997	11	promoting	promote	VBG
cord-006229-7yoilsho	997	12	effects	effect	NNS
cord-006229-7yoilsho	997	13	of	of	IN
cord-006229-7yoilsho	997	14	oral	oral	JJ
cord-006229-7yoilsho	997	15	progesterone	progesterone	NN
cord-006229-7yoilsho	997	16	replacement	replacement	NN
cord-006229-7yoilsho	997	17	in	in	IN
cord-006229-7yoilsho	997	18	postmenopausal	postmenopausal	JJ
cord-006229-7yoilsho	997	19	women	woman	NNS
cord-006229-7yoilsho	997	20	[	[	-LRB-
cord-006229-7yoilsho	997	21	1	1	CD
cord-006229-7yoilsho	997	22	]	]	-RRB-
cord-006229-7yoilsho	997	23	.	.	.
cord-006229-7yoilsho	998	1	The	the	DT
cord-006229-7yoilsho	998	2	oral	oral	JJ
cord-006229-7yoilsho	998	3	administration	administration	NN
cord-006229-7yoilsho	998	4	of	of	IN
cord-006229-7yoilsho	998	5	progesterone	progesterone	NN
cord-006229-7yoilsho	998	6	,	,	,
cord-006229-7yoilsho	998	7	however	however	RB
cord-006229-7yoilsho	998	8	,	,	,
cord-006229-7yoilsho	998	9	is	be	VBZ
cord-006229-7yoilsho	998	10	compromised	compromise	VBN
cord-006229-7yoilsho	998	11	by	by	IN
cord-006229-7yoilsho	998	12	individual	individual	JJ
cord-006229-7yoilsho	998	13	differences	difference	NNS
cord-006229-7yoilsho	998	14	in	in	IN
cord-006229-7yoilsho	998	15	bioavailability	bioavailability	NN
cord-006229-7yoilsho	998	16	and	and	CC
cord-006229-7yoilsho	998	17	metabolism	metabolism	NN
cord-006229-7yoilsho	998	18	of	of	IN
cord-006229-7yoilsho	998	19	the	the	DT
cord-006229-7yoilsho	998	20	steroid	steroid	NN
cord-006229-7yoilsho	998	21	.	.	.
cord-006229-7yoilsho	999	1	We	-PRON-	PRP
cord-006229-7yoilsho	999	2	therefore	therefore	RB
cord-006229-7yoilsho	999	3	investigated	investigate	VBD
cord-006229-7yoilsho	999	4	the	the	DT
cord-006229-7yoilsho	999	5	sleep	sleep	NN
cord-006229-7yoilsho	999	6	-	-	HYPH
cord-006229-7yoilsho	999	7	EEG	EEG	NNP
cord-006229-7yoilsho	999	8	effects	effect	NNS
cord-006229-7yoilsho	999	9	after	after	IN
cord-006229-7yoilsho	999	10	intranasal	intranasal	NN
cord-006229-7yoilsho	999	11	application	application	NN
cord-006229-7yoilsho	999	12	of	of	IN
cord-006229-7yoilsho	999	13	progesterone	progesterone	NN
cord-006229-7yoilsho	999	14	in	in	IN
cord-006229-7yoilsho	999	15	12	12	CD
cord-006229-7yoilsho	999	16	healthy	healthy	JJ
cord-006229-7yoilsho	999	17	postmenopausal	postmenopausal	JJ
cord-006229-7yoilsho	999	18	women	woman	NNS
cord-006229-7yoilsho	999	19	(	(	-LRB-
cord-006229-7yoilsho	999	20	50	50	CD
cord-006229-7yoilsho	999	21	-	-	SYM
cord-006229-7yoilsho	999	22	70	70	CD
cord-006229-7yoilsho	999	23	yrs).In	yrs).In	NNP
cord-006229-7yoilsho	999	24	a	a	DT
cord-006229-7yoilsho	999	25	randomized	randomized	JJ
cord-006229-7yoilsho	999	26	doubleblind	doubleblind	NN
cord-006229-7yoilsho	999	27	protocol	protocol	NN
cord-006229-7yoilsho	999	28	each	each	DT
cord-006229-7yoilsho	999	29	subject	subject	NN
cord-006229-7yoilsho	999	30	received	receive	VBD
cord-006229-7yoilsho	999	31	four	four	CD
cord-006229-7yoilsho	999	32	treatments	treatment	NNS
cord-006229-7yoilsho	999	33	,	,	,
cord-006229-7yoilsho	999	34	2	2	CD
cord-006229-7yoilsho	999	35	doses	dose	NNS
cord-006229-7yoilsho	999	36	of	of	IN
cord-006229-7yoilsho	999	37	intranasal	intranasal	NN
cord-006229-7yoilsho	999	38	progesterone	progesterone	NN
cord-006229-7yoilsho	999	39	(	(	-LRB-
cord-006229-7yoilsho	999	40	4.5	4.5	CD
cord-006229-7yoilsho	999	41	mg	mg	NN
cord-006229-7yoilsho	999	42	MPP22	MPP22	NNP
cord-006229-7yoilsho	999	43	;	;	:
cord-006229-7yoilsho	999	44	9.0	9.0	CD
cord-006229-7yoilsho	999	45	mg	mg	NN
cord-006229-7yoilsho	999	46	MPP22	MPP22	NNP
cord-006229-7yoilsho	999	47	)	)	-RRB-
cord-006229-7yoilsho	999	48	,	,	,
cord-006229-7yoilsho	999	49	10	10	CD
cord-006229-7yoilsho	999	50	mg	mg	NN
cord-006229-7yoilsho	999	51	of	of	IN
cord-006229-7yoilsho	999	52	zolpidem	zolpidem	NNP
cord-006229-7yoilsho	999	53	and	and	CC
cord-006229-7yoilsho	999	54	placebo	placebo	NN
cord-006229-7yoilsho	999	55	.	.	.
cord-006229-7yoilsho	1000	1	The	the	DT
cord-006229-7yoilsho	1000	2	4	4	CD
cord-006229-7yoilsho	1000	3	conditions	condition	NNS
cord-006229-7yoilsho	1000	4	consisted	consist	VBD
cord-006229-7yoilsho	1000	5	of	of	IN
cord-006229-7yoilsho	1000	6	2	2	CD
cord-006229-7yoilsho	1000	7	experimental	experimental	JJ
cord-006229-7yoilsho	1000	8	nights	night	NNS
cord-006229-7yoilsho	1000	9	(	(	-LRB-
cord-006229-7yoilsho	1000	10	adaptation	adaptation	NN
cord-006229-7yoilsho	1000	11	+	+	CC
cord-006229-7yoilsho	1000	12	examination	examination	NN
cord-006229-7yoilsho	1000	13	)	)	-RRB-
cord-006229-7yoilsho	1000	14	separated	separate	VBN
cord-006229-7yoilsho	1000	15	by	by	IN
cord-006229-7yoilsho	1000	16	at	at	RB
cord-006229-7yoilsho	1000	17	least	least	RBS
cord-006229-7yoilsho	1000	18	one	one	CD
cord-006229-7yoilsho	1000	19	week	week	NN
cord-006229-7yoilsho	1000	20	.	.	.
cord-006229-7yoilsho	1001	1	During	during	IN
cord-006229-7yoilsho	1001	2	each	each	DT
cord-006229-7yoilsho	1001	3	examination	examination	NN
cord-006229-7yoilsho	1001	4	sleep	sleep	NN
cord-006229-7yoilsho	1001	5	EEG	EEG	NNP
cord-006229-7yoilsho	1001	6	was	be	VBD
cord-006229-7yoilsho	1001	7	recorded	record	VBN
cord-006229-7yoilsho	1001	8	from	from	IN
cord-006229-7yoilsho	1001	9	23:00	23:00	CD
cord-006229-7yoilsho	1001	10	to	to	IN
cord-006229-7yoilsho	1001	11	07:00	07:00	CD
cord-006229-7yoilsho	1001	12	.	.	.
cord-006229-7yoilsho	1002	1	Simultaneously	simultaneously	RB
cord-006229-7yoilsho	1002	2	blood	blood	NN
cord-006229-7yoilsho	1002	3	was	be	VBD
cord-006229-7yoilsho	1002	4	collected	collect	VBN
cord-006229-7yoilsho	1002	5	every	every	DT
cord-006229-7yoilsho	1002	6	20	20	CD
cord-006229-7yoilsho	1002	7	min	min	NN
cord-006229-7yoilsho	1002	8	between	between	IN
cord-006229-7yoilsho	1002	9	22:00	22:00	CD
cord-006229-7yoilsho	1002	10	and	and	CC
cord-006229-7yoilsho	1002	11	07:00	07:00	CD
cord-006229-7yoilsho	1002	12	by	by	IN
cord-006229-7yoilsho	1002	13	long	long	JJ
cord-006229-7yoilsho	1002	14	catheter	catheter	NN
cord-006229-7yoilsho	1002	15	for	for	IN
cord-006229-7yoilsho	1002	16	later	later	JJ
cord-006229-7yoilsho	1002	17	analysis	analysis	NN
cord-006229-7yoilsho	1002	18	of	of	IN
cord-006229-7yoilsho	1002	19	the	the	DT
cord-006229-7yoilsho	1002	20	hormones	hormone	NNS
cord-006229-7yoilsho	1002	21	growth	growth	NN
cord-006229-7yoilsho	1002	22	hormone	hormone	NN
cord-006229-7yoilsho	1002	23	(	(	-LRB-
cord-006229-7yoilsho	1002	24	GH	GH	NNP
cord-006229-7yoilsho	1002	25	)	)	-RRB-
cord-006229-7yoilsho	1002	26	,	,	,
cord-006229-7yoilsho	1002	27	cortisol	cortisol	NN
cord-006229-7yoilsho	1002	28	,	,	,
cord-006229-7yoilsho	1002	29	melatonin	melatonin	NN
cord-006229-7yoilsho	1002	30	and	and	CC
cord-006229-7yoilsho	1002	31	progesterone	progesterone	NN
cord-006229-7yoilsho	1002	32	.	.	.
cord-006229-7yoilsho	1003	1	Conventional	conventional	JJ
cord-006229-7yoilsho	1003	2	sleep	sleep	NN
cord-006229-7yoilsho	1003	3	-	-	HYPH
cord-006229-7yoilsho	1003	4	EEG	EEG	NNP
cord-006229-7yoilsho	1003	5	was	be	VBD
cord-006229-7yoilsho	1003	6	statistically	statistically	RB
cord-006229-7yoilsho	1003	7	evaluated	evaluate	VBN
cord-006229-7yoilsho	1003	8	by	by	IN
cord-006229-7yoilsho	1003	9	multivariate	multivariate	JJ
cord-006229-7yoilsho	1003	10	analyses	analysis	NNS
cord-006229-7yoilsho	1003	11	of	of	IN
cord-006229-7yoilsho	1003	12	variances	variance	NNS
cord-006229-7yoilsho	1003	13	(	(	-LRB-
cord-006229-7yoilsho	1003	14	MANOVAs	manova	NNS
cord-006229-7yoilsho	1003	15	)	)	-RRB-
cord-006229-7yoilsho	1003	16	with	with	IN
cord-006229-7yoilsho	1003	17	repeated	repeat	VBN
cord-006229-7yoilsho	1003	18	measures	measure	NNS
cord-006229-7yoilsho	1003	19	designs	design	NNS
cord-006229-7yoilsho	1003	20	after	after	IN
cord-006229-7yoilsho	1003	21	removal	removal	NN
cord-006229-7yoilsho	1003	22	of	of	IN
cord-006229-7yoilsho	1003	23	two	two	CD
cord-006229-7yoilsho	1003	24	outliers	outlier	NNS
cord-006229-7yoilsho	1003	25	,	,	,
cord-006229-7yoilsho	1003	26	which	which	WDT
cord-006229-7yoilsho	1003	27	showed	show	VBD
cord-006229-7yoilsho	1003	28	a	a	DT
cord-006229-7yoilsho	1003	29	low	low	JJ
cord-006229-7yoilsho	1003	30	sleep	sleep	NN
cord-006229-7yoilsho	1003	31	efficiency	efficiency	NN
cord-006229-7yoilsho	1003	32	index	index	NN
cord-006229-7yoilsho	1003	33	(	(	-LRB-
cord-006229-7yoilsho	1003	34	SEI	SEI	NNP
cord-006229-7yoilsho	1003	35	)	)	-RRB-
cord-006229-7yoilsho	1003	36	after	after	IN
cord-006229-7yoilsho	1003	37	4.5	4.5	CD
cord-006229-7yoilsho	1003	38	and	and	CC
cord-006229-7yoilsho	1003	39	9.0	9.0	CD
cord-006229-7yoilsho	1003	40	mg	mg	NN
cord-006229-7yoilsho	1003	41	MPP22	MPP22	NNP
cord-006229-7yoilsho	1003	42	.	.	.
cord-006229-7yoilsho	1004	1	Univariate	Univariate	NNP
cord-006229-7yoilsho	1004	2	F	F	NNP
cord-006229-7yoilsho	1004	3	-	-	HYPH
cord-006229-7yoilsho	1004	4	tests	test	NNS
cord-006229-7yoilsho	1004	5	in	in	IN
cord-006229-7yoilsho	1004	6	the	the	DT
cord-006229-7yoilsho	1004	7	MANOVAs	manova	NNS
cord-006229-7yoilsho	1004	8	pointed	point	VBD
cord-006229-7yoilsho	1004	9	to	to	IN
cord-006229-7yoilsho	1004	10	the	the	DT
cord-006229-7yoilsho	1004	11	following	follow	VBG
cord-006229-7yoilsho	1004	12	results	result	NNS
cord-006229-7yoilsho	1004	13	(	(	-LRB-
cord-006229-7yoilsho	1004	14	significant	significant	JJ
cord-006229-7yoilsho	1004	15	p	p	NN
cord-006229-7yoilsho	1004	16	-	-	HYPH
cord-006229-7yoilsho	1004	17	values	value	NNS
cord-006229-7yoilsho	1004	18	at	at	IN
cord-006229-7yoilsho	1004	19	α=0.05	α=0.05	NNP
cord-006229-7yoilsho	1004	20	)	)	-RRB-
cord-006229-7yoilsho	1004	21	.	.	.
cord-006229-7yoilsho	1005	1	SEI	SEI	NNP
cord-006229-7yoilsho	1005	2	was	be	VBD
cord-006229-7yoilsho	1005	3	higher	high	JJR
cord-006229-7yoilsho	1005	4	after	after	IN
cord-006229-7yoilsho	1005	5	zolpidem	zolpidem	NN
cord-006229-7yoilsho	1005	6	than	than	IN
cord-006229-7yoilsho	1005	7	after	after	IN
cord-006229-7yoilsho	1005	8	the	the	DT
cord-006229-7yoilsho	1005	9	other	other	JJ
cord-006229-7yoilsho	1005	10	three	three	CD
cord-006229-7yoilsho	1005	11	treatments	treatment	NNS
cord-006229-7yoilsho	1005	12	.	.	.
cord-006229-7yoilsho	1006	1	After	after	IN
cord-006229-7yoilsho	1006	2	9.0	9.0	CD
cord-006229-7yoilsho	1006	3	mg	mg	NN
cord-006229-7yoilsho	1007	1	MPP22	MPP22	NNP
cord-006229-7yoilsho	1007	2	SEI	SEI	NNP
cord-006229-7yoilsho	1007	3	was	be	VBD
cord-006229-7yoilsho	1007	4	elevated	elevate	VBN
cord-006229-7yoilsho	1007	5	significantly	significantly	RB
cord-006229-7yoilsho	1007	6	in	in	IN
cord-006229-7yoilsho	1007	7	comparison	comparison	NN
cord-006229-7yoilsho	1007	8	to	to	IN
cord-006229-7yoilsho	1007	9	placebo	placebo	NN
cord-006229-7yoilsho	1007	10	.	.	.
cord-006229-7yoilsho	1008	1	Subjects	subject	NNS
cord-006229-7yoilsho	1008	2	spent	spend	VBD
cord-006229-7yoilsho	1008	3	more	more	JJR
cord-006229-7yoilsho	1008	4	time	time	NN
cord-006229-7yoilsho	1008	5	in	in	IN
cord-006229-7yoilsho	1008	6	NonREM	NonREM	NNP
cord-006229-7yoilsho	1008	7	sleep	sleep	NN
cord-006229-7yoilsho	1008	8	and	and	CC
cord-006229-7yoilsho	1008	9	less	less	JJR
cord-006229-7yoilsho	1008	10	time	time	NN
cord-006229-7yoilsho	1008	11	in	in	IN
cord-006229-7yoilsho	1008	12	intermittent	intermittent	JJ
cord-006229-7yoilsho	1008	13	wakefulness	wakefulness	NN
cord-006229-7yoilsho	1008	14	after	after	IN
cord-006229-7yoilsho	1008	15	9.0	9.0	CD
cord-006229-7yoilsho	1008	16	mg	mg	NN
cord-006229-7yoilsho	1008	17	MPP22	MPP22	NNP
cord-006229-7yoilsho	1008	18	and	and	CC
cord-006229-7yoilsho	1008	19	after	after	IN
cord-006229-7yoilsho	1008	20	zolpidem	zolpidem	NNP
cord-006229-7yoilsho	1008	21	than	than	IN
cord-006229-7yoilsho	1008	22	after	after	IN
cord-006229-7yoilsho	1008	23	placebo	placebo	NN
cord-006229-7yoilsho	1008	24	.	.	.
cord-006229-7yoilsho	1009	1	Total	total	JJ
cord-006229-7yoilsho	1009	2	sleep	sleep	NN
cord-006229-7yoilsho	1009	3	time	time	NN
cord-006229-7yoilsho	1009	4	was	be	VBD
cord-006229-7yoilsho	1009	5	elevated	elevate	VBN
cord-006229-7yoilsho	1009	6	and	and	CC
cord-006229-7yoilsho	1009	7	wake	wake	VB
cord-006229-7yoilsho	1009	8	after	after	IN
cord-006229-7yoilsho	1009	9	sleep	sleep	NN
cord-006229-7yoilsho	1009	10	onset	onset	NN
cord-006229-7yoilsho	1009	11	(	(	-LRB-
cord-006229-7yoilsho	1009	12	WASO	WASO	NNP
cord-006229-7yoilsho	1009	13	)	)	-RRB-
cord-006229-7yoilsho	1009	14	was	be	VBD
cord-006229-7yoilsho	1009	15	reduced	reduce	VBN
cord-006229-7yoilsho	1009	16	after	after	IN
cord-006229-7yoilsho	1009	17	9.0	9.0	CD
cord-006229-7yoilsho	1009	18	mg	mg	NN
cord-006229-7yoilsho	1009	19	MPP22	MPP22	NNP
cord-006229-7yoilsho	1009	20	and	and	CC
cord-006229-7yoilsho	1009	21	after	after	IN
cord-006229-7yoilsho	1009	22	zolpidem	zolpidem	NNP
cord-006229-7yoilsho	1009	23	.	.	.
cord-006229-7yoilsho	1010	1	After	after	IN
cord-006229-7yoilsho	1010	2	all	all	DT
cord-006229-7yoilsho	1010	3	active	active	JJ
cord-006229-7yoilsho	1010	4	treatments	treatment	NNS
cord-006229-7yoilsho	1010	5	with	with	IN
cord-006229-7yoilsho	1010	6	MPP22	MPP22	NNP
cord-006229-7yoilsho	1010	7	and	and	CC
cord-006229-7yoilsho	1010	8	zolpidem	zolpidem	NNP
cord-006229-7yoilsho	1010	9	the	the	DT
cord-006229-7yoilsho	1010	10	time	time	NN
cord-006229-7yoilsho	1010	11	spent	spend	VBN
cord-006229-7yoilsho	1010	12	in	in	IN
cord-006229-7yoilsho	1010	13	sleep	sleep	NN
cord-006229-7yoilsho	1010	14	stage	stage	NN
cord-006229-7yoilsho	1010	15	2	2	CD
cord-006229-7yoilsho	1010	16	was	be	VBD
cord-006229-7yoilsho	1010	17	higher	high	JJR
cord-006229-7yoilsho	1010	18	than	than	IN
cord-006229-7yoilsho	1010	19	after	after	IN
cord-006229-7yoilsho	1010	20	placebo	placebo	NN
cord-006229-7yoilsho	1010	21	.	.	.
cord-006229-7yoilsho	1011	1	The	the	DT
cord-006229-7yoilsho	1011	2	amount	amount	NN
cord-006229-7yoilsho	1011	3	of	of	IN
cord-006229-7yoilsho	1011	4	slow	slow	JJ
cord-006229-7yoilsho	1011	5	-	-	HYPH
cord-006229-7yoilsho	1011	6	wave	wave	NN
cord-006229-7yoilsho	1011	7	sleep	sleep	NN
cord-006229-7yoilsho	1011	8	was	be	VBD
cord-006229-7yoilsho	1011	9	higher	high	JJR
cord-006229-7yoilsho	1011	10	after	after	IN
cord-006229-7yoilsho	1011	11	zolpidem	zolpidem	NN
cord-006229-7yoilsho	1011	12	than	than	IN
cord-006229-7yoilsho	1011	13	after	after	IN
cord-006229-7yoilsho	1011	14	placebo	placebo	NN
cord-006229-7yoilsho	1011	15	.	.	.
cord-006229-7yoilsho	1012	1	In	in	IN
cord-006229-7yoilsho	1012	2	addition	addition	NN
cord-006229-7yoilsho	1012	3	,	,	,
cord-006229-7yoilsho	1012	4	the	the	DT
cord-006229-7yoilsho	1012	5	higher	high	JJR
cord-006229-7yoilsho	1012	6	dose	dose	NN
cord-006229-7yoilsho	1012	7	of	of	IN
cord-006229-7yoilsho	1012	8	MPP22	MPP22	NNP
cord-006229-7yoilsho	1012	9	resulted	result	VBD
cord-006229-7yoilsho	1012	10	in	in	IN
cord-006229-7yoilsho	1012	11	an	an	DT
cord-006229-7yoilsho	1012	12	increase	increase	NN
cord-006229-7yoilsho	1012	13	of	of	IN
cord-006229-7yoilsho	1012	14	spindle	spindle	NN
cord-006229-7yoilsho	1012	15	and	and	CC
cord-006229-7yoilsho	1012	16	β	β	NN
cord-006229-7yoilsho	1012	17	frequencies	frequency	NNS
cord-006229-7yoilsho	1012	18	combined	combine	VBN
cord-006229-7yoilsho	1012	19	with	with	IN
cord-006229-7yoilsho	1012	20	a	a	DT
cord-006229-7yoilsho	1012	21	decrease	decrease	NN
cord-006229-7yoilsho	1012	22	of	of	IN
cord-006229-7yoilsho	1012	23	δ	δ	NN
cord-006229-7yoilsho	1012	24	oscillations	oscillation	NNS
cord-006229-7yoilsho	1012	25	during	during	IN
cord-006229-7yoilsho	1012	26	NonREM	NonREM	NNP
cord-006229-7yoilsho	1012	27	sleep	sleep	NN
cord-006229-7yoilsho	1012	28	.	.	.
cord-006229-7yoilsho	1013	1	In	in	IN
cord-006229-7yoilsho	1013	2	comparison	comparison	NN
cord-006229-7yoilsho	1013	3	,	,	,
cord-006229-7yoilsho	1013	4	administration	administration	NN
cord-006229-7yoilsho	1013	5	of	of	IN
cord-006229-7yoilsho	1013	6	zolpidem	zolpidem	NNP
cord-006229-7yoilsho	1013	7	resulted	result	VBD
cord-006229-7yoilsho	1013	8	in	in	IN
cord-006229-7yoilsho	1013	9	strong	strong	JJ
cord-006229-7yoilsho	1013	10	increase	increase	NN
cord-006229-7yoilsho	1013	11	of	of	IN
cord-006229-7yoilsho	1013	12	δ	δ	NN
cord-006229-7yoilsho	1013	13	,	,	,
cord-006229-7yoilsho	1013	14	spindle	spindle	NN
cord-006229-7yoilsho	1013	15	and	and	CC
cord-006229-7yoilsho	1013	16	high	high	JJ
cord-006229-7yoilsho	1013	17	β	β	NN
cord-006229-7yoilsho	1013	18	frequencies	frequency	NNS
cord-006229-7yoilsho	1013	19	as	as	RB
cord-006229-7yoilsho	1013	20	well	well	RB
cord-006229-7yoilsho	1013	21	as	as	IN
cord-006229-7yoilsho	1013	22	strong	strong	JJ
cord-006229-7yoilsho	1013	23	decrease	decrease	NN
cord-006229-7yoilsho	1013	24	in	in	IN
cord-006229-7yoilsho	1013	25	θ	θ	NN
cord-006229-7yoilsho	1013	26	and	and	CC
cord-006229-7yoilsho	1013	27	α	α	NN
cord-006229-7yoilsho	1013	28	frequencies	frequency	NNS
cord-006229-7yoilsho	1013	29	.	.	.
cord-006229-7yoilsho	1014	1	Nocturnal	nocturnal	JJ
cord-006229-7yoilsho	1014	2	progesterone	progesterone	NN
cord-006229-7yoilsho	1014	3	levels	level	NNS
cord-006229-7yoilsho	1014	4	increased	increase	VBD
cord-006229-7yoilsho	1014	5	after	after	IN
cord-006229-7yoilsho	1014	6	9.0	9.0	CD
cord-006229-7yoilsho	1014	7	mg	mg	NN
cord-006229-7yoilsho	1014	8	MPP22	MPP22	NNP
cord-006229-7yoilsho	1014	9	.	.	.
cord-006229-7yoilsho	1015	1	No	no	DT
cord-006229-7yoilsho	1015	2	other	other	JJ
cord-006229-7yoilsho	1015	3	changes	change	NNS
cord-006229-7yoilsho	1015	4	of	of	IN
cord-006229-7yoilsho	1015	5	hormone	hormone	NN
cord-006229-7yoilsho	1015	6	secretion	secretion	NN
cord-006229-7yoilsho	1015	7	were	be	VBD
cord-006229-7yoilsho	1015	8	found	find	VBN
cord-006229-7yoilsho	1015	9	.	.	.
cord-006229-7yoilsho	1016	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	1016	2	study	study	NN
cord-006229-7yoilsho	1016	3	show	show	NN
cord-006229-7yoilsho	1016	4	sleep	sleep	NN
cord-006229-7yoilsho	1016	5	promoting	promote	VBG
cord-006229-7yoilsho	1016	6	effects	effect	NNS
cord-006229-7yoilsho	1016	7	of	of	IN
cord-006229-7yoilsho	1016	8	9.0	9.0	CD
cord-006229-7yoilsho	1016	9	mg	mg	NNP
cord-006229-7yoilsho	1016	10	MPP	MPP	NNP
cord-006229-7yoilsho	1016	11	.	.	.
cord-006229-7yoilsho	1017	1	As	as	IN
cord-006229-7yoilsho	1017	2	expected	expect	VBN
cord-006229-7yoilsho	1017	3	the	the	DT
cord-006229-7yoilsho	1017	4	sleep	sleep	NN
cord-006229-7yoilsho	1017	5	promoting	promote	VBG
cord-006229-7yoilsho	1017	6	effect	effect	NN
cord-006229-7yoilsho	1017	7	of	of	IN
cord-006229-7yoilsho	1017	8	zolpidem	zolpidem	NNP
cord-006229-7yoilsho	1017	9	was	be	VBD
cord-006229-7yoilsho	1017	10	confirmed	confirm	VBN
cord-006229-7yoilsho	1017	11	.	.	.
cord-006229-7yoilsho	1018	1	The	the	DT
cord-006229-7yoilsho	1018	2	spectral	spectral	JJ
cord-006229-7yoilsho	1018	3	signature	signature	NN
cord-006229-7yoilsho	1018	4	of	of	IN
cord-006229-7yoilsho	1018	5	intranasal	intranasal	NN
cord-006229-7yoilsho	1018	6	progesterone	progesterone	NN
cord-006229-7yoilsho	1018	7	partly	partly	RB
cord-006229-7yoilsho	1018	8	resembled	resemble	VBD
cord-006229-7yoilsho	1018	9	the	the	DT
cord-006229-7yoilsho	1018	10	well	well	RB
cord-006229-7yoilsho	1018	11	-	-	HYPH
cord-006229-7yoilsho	1018	12	known	know	VBN
cord-006229-7yoilsho	1018	13	sleep	sleep	NN
cord-006229-7yoilsho	1018	14	-	-	HYPH
cord-006229-7yoilsho	1018	15	EEG	EEG	NNP
cord-006229-7yoilsho	1018	16	alterations	alteration	NNS
cord-006229-7yoilsho	1018	17	induced	induce	VBN
cord-006229-7yoilsho	1018	18	by	by	IN
cord-006229-7yoilsho	1018	19	GABA	GABA	NNP
cord-006229-7yoilsho	1018	20	active	active	JJ
cord-006229-7yoilsho	1018	21	compounds	compound	NNS
cord-006229-7yoilsho	1018	22	.	.	.
cord-006229-7yoilsho	1019	1	Progestereone	Progestereone	NNP
cord-006229-7yoilsho	1019	2	levels	level	NNS
cord-006229-7yoilsho	1019	3	were	be	VBD
cord-006229-7yoilsho	1019	4	elevated	elevate	VBN
cord-006229-7yoilsho	1019	5	after	after	IN
cord-006229-7yoilsho	1019	6	9.0	9.0	CD
cord-006229-7yoilsho	1019	7	mg	mg	NN
cord-006229-7yoilsho	1019	8	MPP22	MPP22	NNP
cord-006229-7yoilsho	1019	9	.	.	.
cord-006229-7yoilsho	1020	1	No	no	DT
cord-006229-7yoilsho	1020	2	other	other	JJ
cord-006229-7yoilsho	1020	3	endocrine	endocrine	JJ
cord-006229-7yoilsho	1020	4	effects	effect	NNS
cord-006229-7yoilsho	1020	5	were	be	VBD
cord-006229-7yoilsho	1020	6	observed	observe	VBN
cord-006229-7yoilsho	1020	7	.	.	.
cord-006229-7yoilsho	1021	1	Introduction	introduction	NN
cord-006229-7yoilsho	1021	2	:	:	:
cord-006229-7yoilsho	1022	1	Anticholinergic	anticholinergic	NN
cord-006229-7yoilsho	1022	2	drugs	drug	NNS
cord-006229-7yoilsho	1022	3	or	or	CC
cord-006229-7yoilsho	1022	4	drugs	drug	NNS
cord-006229-7yoilsho	1022	5	with	with	IN
cord-006229-7yoilsho	1022	6	anticholinergic	anticholinergic	JJ
cord-006229-7yoilsho	1022	7	side	side	NN
cord-006229-7yoilsho	1022	8	effects	effect	NNS
cord-006229-7yoilsho	1022	9	are	be	VBP
cord-006229-7yoilsho	1022	10	commonly	commonly	RB
cord-006229-7yoilsho	1022	11	used	use	VBN
cord-006229-7yoilsho	1022	12	for	for	IN
cord-006229-7yoilsho	1022	13	the	the	DT
cord-006229-7yoilsho	1022	14	treatment	treatment	NN
cord-006229-7yoilsho	1022	15	of	of	IN
cord-006229-7yoilsho	1022	16	various	various	JJ
cord-006229-7yoilsho	1022	17	diseases	disease	NNS
cord-006229-7yoilsho	1022	18	in	in	IN
cord-006229-7yoilsho	1022	19	the	the	DT
cord-006229-7yoilsho	1022	20	elderly	elderly	JJ
cord-006229-7yoilsho	1022	21	population	population	NN
cord-006229-7yoilsho	1022	22	.	.	.
cord-006229-7yoilsho	1023	1	Elderly	elderly	JJ
cord-006229-7yoilsho	1023	2	patients	patient	NNS
cord-006229-7yoilsho	1023	3	are	be	VBP
cord-006229-7yoilsho	1023	4	particularly	particularly	RB
cord-006229-7yoilsho	1023	5	vulnerable	vulnerable	JJ
cord-006229-7yoilsho	1023	6	to	to	IN
cord-006229-7yoilsho	1023	7	anticholinergic	anticholinergic	JJ
cord-006229-7yoilsho	1023	8	-	-	HYPH
cord-006229-7yoilsho	1023	9	related	relate	VBN
cord-006229-7yoilsho	1023	10	cognitive	cognitive	JJ
cord-006229-7yoilsho	1023	11	effects	effect	NNS
cord-006229-7yoilsho	1023	12	.	.	.
cord-006229-7yoilsho	1024	1	Moreover	moreover	RB
cord-006229-7yoilsho	1024	2	,	,	,
cord-006229-7yoilsho	1024	3	there	there	EX
cord-006229-7yoilsho	1024	4	is	be	VBZ
cord-006229-7yoilsho	1024	5	a	a	DT
cord-006229-7yoilsho	1024	6	relationship	relationship	NN
cord-006229-7yoilsho	1024	7	between	between	IN
cord-006229-7yoilsho	1024	8	anticholinergic	anticholinergic	JJ
cord-006229-7yoilsho	1024	9	exposure	exposure	NN
cord-006229-7yoilsho	1024	10	and	and	CC
cord-006229-7yoilsho	1024	11	cognitive	cognitive	JJ
cord-006229-7yoilsho	1024	12	impairment	impairment	NN
cord-006229-7yoilsho	1024	13	.	.	.
cord-006229-7yoilsho	1025	1	However	however	RB
cord-006229-7yoilsho	1025	2	,	,	,
cord-006229-7yoilsho	1025	3	there	there	EX
cord-006229-7yoilsho	1025	4	is	be	VBZ
cord-006229-7yoilsho	1025	5	currently	currently	RB
cord-006229-7yoilsho	1025	6	a	a	DT
cord-006229-7yoilsho	1025	7	lack	lack	NN
cord-006229-7yoilsho	1025	8	of	of	IN
cord-006229-7yoilsho	1025	9	data	datum	NNS
cord-006229-7yoilsho	1025	10	on	on	IN
cord-006229-7yoilsho	1025	11	the	the	DT
cord-006229-7yoilsho	1025	12	anticholinergic	anticholinergic	JJ
cord-006229-7yoilsho	1025	13	burden	burden	NN
cord-006229-7yoilsho	1025	14	in	in	IN
cord-006229-7yoilsho	1025	15	geriatric	geriatric	JJ
cord-006229-7yoilsho	1025	16	patients	patient	NNS
cord-006229-7yoilsho	1025	17	in	in	IN
cord-006229-7yoilsho	1025	18	Germany	Germany	NNP
cord-006229-7yoilsho	1025	19	.	.	.
cord-006229-7yoilsho	1026	1	It	-PRON-	PRP
cord-006229-7yoilsho	1026	2	was	be	VBD
cord-006229-7yoilsho	1026	3	therefore	therefore	RB
cord-006229-7yoilsho	1026	4	the	the	DT
cord-006229-7yoilsho	1026	5	aim	aim	NN
cord-006229-7yoilsho	1026	6	of	of	IN
cord-006229-7yoilsho	1026	7	this	this	DT
cord-006229-7yoilsho	1026	8	study	study	NN
cord-006229-7yoilsho	1026	9	to	to	TO
cord-006229-7yoilsho	1026	10	evaluate	evaluate	VB
cord-006229-7yoilsho	1026	11	the	the	DT
cord-006229-7yoilsho	1026	12	anticholinergic	anticholinergic	JJ
cord-006229-7yoilsho	1026	13	burden	burden	NN
cord-006229-7yoilsho	1026	14	in	in	IN
cord-006229-7yoilsho	1026	15	a	a	DT
cord-006229-7yoilsho	1026	16	large	large	JJ
cord-006229-7yoilsho	1026	17	representative	representative	JJ
cord-006229-7yoilsho	1026	18	cohort	cohort	NN
cord-006229-7yoilsho	1026	19	of	of	IN
cord-006229-7yoilsho	1026	20	geriatric	geriatric	JJ
cord-006229-7yoilsho	1026	21	patients	patient	NNS
cord-006229-7yoilsho	1026	22	.	.	.
cord-006229-7yoilsho	1027	1	Materials	material	NNS
cord-006229-7yoilsho	1027	2	and	and	CC
cord-006229-7yoilsho	1027	3	Methods	method	NNS
cord-006229-7yoilsho	1027	4	:	:	:
cord-006229-7yoilsho	1027	5	In	in	IN
cord-006229-7yoilsho	1027	6	this	this	DT
cord-006229-7yoilsho	1027	7	retrospective	retrospective	JJ
cord-006229-7yoilsho	1027	8	cohort	cohort	NN
cord-006229-7yoilsho	1027	9	study	study	NN
cord-006229-7yoilsho	1027	10	,	,	,
cord-006229-7yoilsho	1027	11	(	(	-LRB-
cord-006229-7yoilsho	1027	12	co)-prescriptions	co)-prescription	NNS
cord-006229-7yoilsho	1027	13	of	of	IN
cord-006229-7yoilsho	1027	14	anticholinergic	anticholinergic	JJ
cord-006229-7yoilsho	1027	15	drugs	drug	NNS
cord-006229-7yoilsho	1027	16	as	as	RB
cord-006229-7yoilsho	1027	17	well	well	RB
cord-006229-7yoilsho	1027	18	as	as	IN
cord-006229-7yoilsho	1027	19	anti	anti	JJ
cord-006229-7yoilsho	1027	20	-	-	JJ
cord-006229-7yoilsho	1027	21	dementia	dementia	JJ
cord-006229-7yoilsho	1027	22	drugs	drug	NNS
cord-006229-7yoilsho	1027	23	were	be	VBD
cord-006229-7yoilsho	1027	24	evaluated	evaluate	VBN
cord-006229-7yoilsho	1027	25	using	use	VBG
cord-006229-7yoilsho	1027	26	the	the	DT
cord-006229-7yoilsho	1027	27	discharge	discharge	NN
cord-006229-7yoilsho	1027	28	medication	medication	NN
cord-006229-7yoilsho	1027	29	of	of	IN
cord-006229-7yoilsho	1027	30	geriatric	geriatric	JJ
cord-006229-7yoilsho	1027	31	patients	patient	NNS
cord-006229-7yoilsho	1027	32	between	between	IN
cord-006229-7yoilsho	1027	33	January	January	NNP
cord-006229-7yoilsho	1027	34	2013	2013	CD
cord-006229-7yoilsho	1027	35	and	and	CC
cord-006229-7yoilsho	1027	36	June	June	NNP
cord-006229-7yoilsho	1027	37	2015	2015	CD
cord-006229-7yoilsho	1027	38	from	from	IN
cord-006229-7yoilsho	1027	39	the	the	DT
cord-006229-7yoilsho	1027	40	Geriatrics	Geriatrics	NNPS
cord-006229-7yoilsho	1027	41	in	in	IN
cord-006229-7yoilsho	1027	42	Bavaria	Bavaria	NNP
cord-006229-7yoilsho	1027	43	-	-	HYPH
cord-006229-7yoilsho	1027	44	Database	Database	NNP
cord-006229-7yoilsho	1027	45	(	(	-LRB-
cord-006229-7yoilsho	1027	46	GiB	GiB	NNP
cord-006229-7yoilsho	1027	47	-	-	HYPH
cord-006229-7yoilsho	1027	48	DAT	DAT	NNP
cord-006229-7yoilsho	1027	49	)	)	-RRB-
cord-006229-7yoilsho	1027	50	.	.	.
cord-006229-7yoilsho	1028	1	Anticholinergic	anticholinergic	NN
cord-006229-7yoilsho	1028	2	drugs	drug	NNS
cord-006229-7yoilsho	1028	3	were	be	VBD
cord-006229-7yoilsho	1028	4	classified	classify	VBN
cord-006229-7yoilsho	1028	5	according	accord	VBG
cord-006229-7yoilsho	1028	6	to	to	IN
cord-006229-7yoilsho	1028	7	the	the	DT
cord-006229-7yoilsho	1028	8	Anticholinergic	Anticholinergic	NNP
cord-006229-7yoilsho	1028	9	Cognitive	Cognitive	NNP
cord-006229-7yoilsho	1028	10	Burden	Burden	NNP
cord-006229-7yoilsho	1028	11	(	(	-LRB-
cord-006229-7yoilsho	1028	12	ACB	ACB	NNP
cord-006229-7yoilsho	1028	13	)	)	-RRB-
cord-006229-7yoilsho	1028	14	Scale	scale	NN
cord-006229-7yoilsho	1028	15	in	in	IN
cord-006229-7yoilsho	1028	16	three	three	CD
cord-006229-7yoilsho	1028	17	groups	group	NNS
cord-006229-7yoilsho	1028	18	(	(	-LRB-
cord-006229-7yoilsho	1028	19	definite	definite	JJ
cord-006229-7yoilsho	1028	20	anticholinergics	anticholinergic	NNS
cord-006229-7yoilsho	1028	21	with	with	IN
cord-006229-7yoilsho	1028	22	a	a	DT
cord-006229-7yoilsho	1028	23	score	score	NN
cord-006229-7yoilsho	1028	24	of	of	IN
cord-006229-7yoilsho	1028	25	2	2	CD
cord-006229-7yoilsho	1028	26	or	or	CC
cord-006229-7yoilsho	1028	27	3	3	CD
cord-006229-7yoilsho	1028	28	and	and	CC
cord-006229-7yoilsho	1028	29	possible	possible	JJ
cord-006229-7yoilsho	1028	30	anticholinergics	anticholinergic	NNS
cord-006229-7yoilsho	1028	31	with	with	IN
cord-006229-7yoilsho	1028	32	a	a	DT
cord-006229-7yoilsho	1028	33	score	score	NN
cord-006229-7yoilsho	1028	34	of	of	IN
cord-006229-7yoilsho	1028	35	1	1	CD
cord-006229-7yoilsho	1028	36	)	)	-RRB-
cord-006229-7yoilsho	1028	37	.	.	.
cord-006229-7yoilsho	1029	1	The	the	DT
cord-006229-7yoilsho	1029	2	ACB	ACB	NNP
cord-006229-7yoilsho	1029	3	scale	scale	NN
cord-006229-7yoilsho	1029	4	was	be	VBD
cord-006229-7yoilsho	1029	5	modified	modify	VBN
cord-006229-7yoilsho	1029	6	by	by	IN
cord-006229-7yoilsho	1029	7	omitting	omit	VBG
cord-006229-7yoilsho	1029	8	trospium	trospium	NN
cord-006229-7yoilsho	1029	9	and	and	CC
cord-006229-7yoilsho	1029	10	by	by	IN
cord-006229-7yoilsho	1029	11	adding	add	VBG
cord-006229-7yoilsho	1029	12	the	the	DT
cord-006229-7yoilsho	1029	13	three	three	CD
cord-006229-7yoilsho	1029	14	drugs	drug	NNS
cord-006229-7yoilsho	1029	15	biperiden	biperiden	NNP
cord-006229-7yoilsho	1029	16	,	,	,
cord-006229-7yoilsho	1029	17	metixen	metixen	NNP
cord-006229-7yoilsho	1029	18	and	and	CC
cord-006229-7yoilsho	1029	19	maprotilin	maprotilin	NNP
cord-006229-7yoilsho	1029	20	,	,	,
cord-006229-7yoilsho	1029	21	which	which	WDT
cord-006229-7yoilsho	1029	22	are	be	VBP
cord-006229-7yoilsho	1029	23	used	use	VBN
cord-006229-7yoilsho	1029	24	in	in	IN
cord-006229-7yoilsho	1029	25	Germany	Germany	NNP
cord-006229-7yoilsho	1029	26	,	,	,
cord-006229-7yoilsho	1029	27	with	with	IN
cord-006229-7yoilsho	1029	28	a	a	DT
cord-006229-7yoilsho	1029	29	score	score	NN
cord-006229-7yoilsho	1029	30	of	of	IN
cord-006229-7yoilsho	1029	31	3	3	CD
cord-006229-7yoilsho	1029	32	.	.	.
cord-006229-7yoilsho	1030	1	A	a	DT
cord-006229-7yoilsho	1030	2	patient	patient	NN
cord-006229-7yoilsho	1030	3	's	's	POS
cord-006229-7yoilsho	1030	4	individual	individual	JJ
cord-006229-7yoilsho	1030	5	score	score	NN
cord-006229-7yoilsho	1030	6	of	of	IN
cord-006229-7yoilsho	1030	7	3	3	CD
cord-006229-7yoilsho	1030	8	or	or	CC
cord-006229-7yoilsho	1030	9	higher	high	JJR
cord-006229-7yoilsho	1030	10	is	be	VBZ
cord-006229-7yoilsho	1030	11	considered	consider	VBN
cord-006229-7yoilsho	1030	12	to	to	TO
cord-006229-7yoilsho	1030	13	be	be	VB
cord-006229-7yoilsho	1030	14	clinically	clinically	RB
cord-006229-7yoilsho	1030	15	relevant	relevant	JJ
cord-006229-7yoilsho	1030	16	.	.	.
cord-006229-7yoilsho	1031	1	In	in	IN
cord-006229-7yoilsho	1031	2	total	total	JJ
cord-006229-7yoilsho	1031	3	,	,	,
cord-006229-7yoilsho	1031	4	130,186	130,186	CD
cord-006229-7yoilsho	1031	5	geriatric	geriatric	JJ
cord-006229-7yoilsho	1031	6	patients	patient	NNS
cord-006229-7yoilsho	1031	7	(	(	-LRB-
cord-006229-7yoilsho	1031	8	median	median	JJ
cord-006229-7yoilsho	1031	9	age	age	NN
cord-006229-7yoilsho	1031	10	82	82	CD
cord-006229-7yoilsho	1031	11	years	year	NNS
cord-006229-7yoilsho	1031	12	,	,	,
cord-006229-7yoilsho	1031	13	66.3	66.3	CD
cord-006229-7yoilsho	1031	14	%	%	NN
cord-006229-7yoilsho	1031	15	female	female	JJ
cord-006229-7yoilsho	1031	16	,	,	,
cord-006229-7yoilsho	1031	17	median	median	JJ
cord-006229-7yoilsho	1031	18	no	no	UH
cord-006229-7yoilsho	1031	19	.	.	NN
cord-006229-7yoilsho	1031	20	of	of	IN
cord-006229-7yoilsho	1031	21	drugs	drug	NNS
cord-006229-7yoilsho	1031	22	9	9	CD
cord-006229-7yoilsho	1031	23	)	)	-RRB-
cord-006229-7yoilsho	1031	24	were	be	VBD
cord-006229-7yoilsho	1031	25	evaluated	evaluate	VBN
cord-006229-7yoilsho	1031	26	.	.	.
cord-006229-7yoilsho	1032	1	Of	of	IN
cord-006229-7yoilsho	1032	2	these	these	DT
cord-006229-7yoilsho	1032	3	,	,	,
cord-006229-7yoilsho	1032	4	41,456	41,456	CD
cord-006229-7yoilsho	1032	5	(	(	-LRB-
cord-006229-7yoilsho	1032	6	31.8	31.8	CD
cord-006229-7yoilsho	1032	7	%	%	NN
cord-006229-7yoilsho	1032	8	)	)	-RRB-
cord-006229-7yoilsho	1032	9	patients	patient	NNS
cord-006229-7yoilsho	1032	10	took	take	VBD
cord-006229-7yoilsho	1032	11	at	at	RB
cord-006229-7yoilsho	1032	12	least	least	RBS
cord-006229-7yoilsho	1032	13	one	one	CD
cord-006229-7yoilsho	1032	14	drug	drug	NN
cord-006229-7yoilsho	1032	15	with	with	IN
cord-006229-7yoilsho	1032	16	anticholinergic	anticholinergic	JJ
cord-006229-7yoilsho	1032	17	properties	property	NNS
cord-006229-7yoilsho	1032	18	.	.	.
cord-006229-7yoilsho	1033	1	Two	two	CD
cord-006229-7yoilsho	1033	2	or	or	CC
cord-006229-7yoilsho	1033	3	more	more	JJR
cord-006229-7yoilsho	1033	4	anticholinergic	anticholinergic	JJ
cord-006229-7yoilsho	1033	5	drugs	drug	NNS
cord-006229-7yoilsho	1033	6	were	be	VBD
cord-006229-7yoilsho	1033	7	coprescribed	coprescribe	VBN
cord-006229-7yoilsho	1033	8	in	in	IN
cord-006229-7yoilsho	1033	9	10,941	10,941	CD
cord-006229-7yoilsho	1033	10	(	(	-LRB-
cord-006229-7yoilsho	1033	11	26.4	26.4	CD
cord-006229-7yoilsho	1033	12	%	%	NN
cord-006229-7yoilsho	1033	13	of	of	IN
cord-006229-7yoilsho	1033	14	the	the	DT
cord-006229-7yoilsho	1033	15	patients	patient	NNS
cord-006229-7yoilsho	1033	16	taking	take	VBG
cord-006229-7yoilsho	1033	17	anticholinergic	anticholinergic	JJ
cord-006229-7yoilsho	1033	18	drugs	drug	NNS
cord-006229-7yoilsho	1033	19	)	)	-RRB-
cord-006229-7yoilsho	1033	20	patients	patient	NNS
cord-006229-7yoilsho	1033	21	.	.	.
cord-006229-7yoilsho	1034	1	11,241	11,241	CD
cord-006229-7yoilsho	1034	2	(	(	-LRB-
cord-006229-7yoilsho	1034	3	27.1	27.1	CD
cord-006229-7yoilsho	1034	4	%	%	NN
cord-006229-7yoilsho	1034	5	of	of	IN
cord-006229-7yoilsho	1034	6	the	the	DT
cord-006229-7yoilsho	1034	7	patients	patient	NNS
cord-006229-7yoilsho	1034	8	taking	take	VBG
cord-006229-7yoilsho	1034	9	anticholinergic	anticholinergic	JJ
cord-006229-7yoilsho	1034	10	drugs	drug	NNS
cord-006229-7yoilsho	1034	11	)	)	-RRB-
cord-006229-7yoilsho	1034	12	patients	patient	NNS
cord-006229-7yoilsho	1034	13	had	have	VBD
cord-006229-7yoilsho	1034	14	a	a	DT
cord-006229-7yoilsho	1034	15	score	score	NN
cord-006229-7yoilsho	1034	16	of	of	IN
cord-006229-7yoilsho	1034	17	3	3	CD
cord-006229-7yoilsho	1034	18	or	or	CC
cord-006229-7yoilsho	1034	19	higher	high	JJR
cord-006229-7yoilsho	1034	20	.	.	.
cord-006229-7yoilsho	1035	1	The	the	DT
cord-006229-7yoilsho	1035	2	most	most	RBS
cord-006229-7yoilsho	1035	3	common	common	JJ
cord-006229-7yoilsho	1035	4	anticholinergic	anticholinergic	JJ
cord-006229-7yoilsho	1035	5	drug	drug	NN
cord-006229-7yoilsho	1035	6	combinations	combination	NNS
cord-006229-7yoilsho	1035	7	involving	involve	VBG
cord-006229-7yoilsho	1035	8	two	two	CD
cord-006229-7yoilsho	1035	9	definite	definite	JJ
cord-006229-7yoilsho	1035	10	anticholinergic	anticholinergic	JJ
cord-006229-7yoilsho	1035	11	drugs	drug	NNS
cord-006229-7yoilsho	1035	12	were	be	VBD
cord-006229-7yoilsho	1035	13	amantadine	amantadine	NNP
cord-006229-7yoilsho	1035	14	/	/	SYM
cord-006229-7yoilsho	1035	15	quetiapine	quetiapine	NNP
cord-006229-7yoilsho	1035	16	(	(	-LRB-
cord-006229-7yoilsho	1035	17	58	58	CD
cord-006229-7yoilsho	1035	18	)	)	-RRB-
cord-006229-7yoilsho	1035	19	,	,	,
cord-006229-7yoilsho	1035	20	amitriptyline	amitriptyline	NN
cord-006229-7yoilsho	1035	21	/	/	,
cord-006229-7yoilsho	1035	22	quetiapine	quetiapine	NNP
cord-006229-7yoilsho	1035	23	(	(	-LRB-
cord-006229-7yoilsho	1035	24	41	41	CD
cord-006229-7yoilsho	1035	25	)	)	-RRB-
cord-006229-7yoilsho	1035	26	and	and	CC
cord-006229-7yoilsho	1035	27	amitriptyline	amitriptyline	NN
cord-006229-7yoilsho	1035	28	/	/	,
cord-006229-7yoilsho	1035	29	carbamazepine	carbamazepine	NN
cord-006229-7yoilsho	1035	30	(	(	-LRB-
cord-006229-7yoilsho	1035	31	35	35	CD
cord-006229-7yoilsho	1035	32	)	)	-RRB-
cord-006229-7yoilsho	1035	33	.	.	.
cord-006229-7yoilsho	1036	1	2,885	2,885	CD
cord-006229-7yoilsho	1036	2	(	(	-LRB-
cord-006229-7yoilsho	1036	3	7.0	7.0	CD
cord-006229-7yoilsho	1036	4	%	%	NN
cord-006229-7yoilsho	1036	5	)	)	-RRB-
cord-006229-7yoilsho	1037	1	patients	patient	NNS
cord-006229-7yoilsho	1037	2	received	receive	VBD
cord-006229-7yoilsho	1037	3	anticholinergic	anticholinergic	JJ
cord-006229-7yoilsho	1037	4	drugs	drug	NNS
cord-006229-7yoilsho	1037	5	in	in	IN
cord-006229-7yoilsho	1037	6	combination	combination	NN
cord-006229-7yoilsho	1037	7	with	with	IN
cord-006229-7yoilsho	1037	8	anti	anti	JJ
cord-006229-7yoilsho	1037	9	-	-	JJ
cord-006229-7yoilsho	1037	10	dementia	dementia	JJ
cord-006229-7yoilsho	1037	11	drugs	drug	NNS
cord-006229-7yoilsho	1037	12	.	.	.
cord-006229-7yoilsho	1038	1	Conclusions	conclusion	NNS
cord-006229-7yoilsho	1038	2	:	:	:
cord-006229-7yoilsho	1039	1	One	one	CD
cord-006229-7yoilsho	1039	2	third	third	NN
cord-006229-7yoilsho	1039	3	of	of	IN
cord-006229-7yoilsho	1039	4	patients	patient	NNS
cord-006229-7yoilsho	1039	5	in	in	IN
cord-006229-7yoilsho	1039	6	a	a	DT
cord-006229-7yoilsho	1039	7	large	large	JJ
cord-006229-7yoilsho	1039	8	geriatric	geriatric	JJ
cord-006229-7yoilsho	1039	9	population	population	NN
cord-006229-7yoilsho	1039	10	were	be	VBD
cord-006229-7yoilsho	1039	11	prescribed	prescribe	VBN
cord-006229-7yoilsho	1039	12	at	at	IN
cord-006229-7yoilsho	1039	13	least	least	RBS
cord-006229-7yoilsho	1039	14	one	one	CD
cord-006229-7yoilsho	1039	15	anticholinergic	anticholinergic	JJ
cord-006229-7yoilsho	1039	16	drug	drug	NN
cord-006229-7yoilsho	1039	17	.	.	.
cord-006229-7yoilsho	1040	1	One	one	CD
cord-006229-7yoilsho	1040	2	quarter	quarter	NN
cord-006229-7yoilsho	1040	3	received	receive	VBD
cord-006229-7yoilsho	1040	4	a	a	DT
cord-006229-7yoilsho	1040	5	co	co	NN
cord-006229-7yoilsho	1040	6	-	-	NN
cord-006229-7yoilsho	1040	7	prescription	prescription	NN
cord-006229-7yoilsho	1040	8	of	of	IN
cord-006229-7yoilsho	1040	9	anticholinergic	anticholinergic	JJ
cord-006229-7yoilsho	1040	10	drugs	drug	NNS
cord-006229-7yoilsho	1040	11	.	.	.
cord-006229-7yoilsho	1041	1	Caution	caution	NN
cord-006229-7yoilsho	1041	2	is	be	VBZ
cord-006229-7yoilsho	1041	3	advised	advise	VBN
cord-006229-7yoilsho	1041	4	prescribing	prescribe	VBG
cord-006229-7yoilsho	1041	5	anticholinergic	anticholinergic	JJ
cord-006229-7yoilsho	1041	6	drugs	drug	NNS
cord-006229-7yoilsho	1041	7	to	to	IN
cord-006229-7yoilsho	1041	8	elderly	elderly	JJ
cord-006229-7yoilsho	1041	9	patients	patient	NNS
cord-006229-7yoilsho	1041	10	especially	especially	RB
cord-006229-7yoilsho	1041	11	with	with	IN
cord-006229-7yoilsho	1041	12	dementia	dementia	NN
cord-006229-7yoilsho	1041	13	.	.	.
cord-006229-7yoilsho	1042	1	The	the	DT
cord-006229-7yoilsho	1042	2	antiglaucoma	antiglaucoma	NNP
cord-006229-7yoilsho	1042	3	agents	agent	NNS
cord-006229-7yoilsho	1042	4	brimonidine	brimonidine	JJ
cord-006229-7yoilsho	1042	5	and	and	CC
cord-006229-7yoilsho	1042	6	timolol	timolol	NNP
cord-006229-7yoilsho	1042	7	are	be	VBP
cord-006229-7yoilsho	1042	8	novel	novel	JJ
cord-006229-7yoilsho	1042	9	substrates	substrate	NNS
cord-006229-7yoilsho	1042	10	of	of	IN
cord-006229-7yoilsho	1042	11	the	the	DT
cord-006229-7yoilsho	1042	12	organic	organic	JJ
cord-006229-7yoilsho	1042	13	cation	cation	NN
cord-006229-7yoilsho	1042	14	transporters	transporter	NNS
cord-006229-7yoilsho	1042	15	OCT2	OCT2	NNP
cord-006229-7yoilsho	1042	16	and	and	CC
cord-006229-7yoilsho	1042	17	MATE1	MATE1	NNS
cord-006229-7yoilsho	1042	18	expressed	express	VBN
cord-006229-7yoilsho	1042	19	in	in	IN
cord-006229-7yoilsho	1042	20	human	human	JJ
cord-006229-7yoilsho	1042	21	eye	eye	NN
cord-006229-7yoilsho	1042	22	C.	C.	NNP
cord-006229-7yoilsho	1042	23	Neul	Neul	NNP
cord-006229-7yoilsho	1042	24	Purpose	Purpose	NNP
cord-006229-7yoilsho	1042	25	:	:	:
cord-006229-7yoilsho	1042	26	Glaucoma	glaucoma	NN
cord-006229-7yoilsho	1042	27	is	be	VBZ
cord-006229-7yoilsho	1042	28	a	a	DT
cord-006229-7yoilsho	1042	29	leading	leading	JJ
cord-006229-7yoilsho	1042	30	cause	cause	NN
cord-006229-7yoilsho	1042	31	of	of	IN
cord-006229-7yoilsho	1042	32	visual	visual	JJ
cord-006229-7yoilsho	1042	33	loss	loss	NN
cord-006229-7yoilsho	1042	34	in	in	IN
cord-006229-7yoilsho	1042	35	the	the	DT
cord-006229-7yoilsho	1042	36	world	world	NN
cord-006229-7yoilsho	1042	37	population	population	NN
cord-006229-7yoilsho	1042	38	.	.	.
cord-006229-7yoilsho	1043	1	Lowering	lower	VBG
cord-006229-7yoilsho	1043	2	intraocular	intraocular	JJ
cord-006229-7yoilsho	1043	3	pressure	pressure	NN
cord-006229-7yoilsho	1043	4	by	by	IN
cord-006229-7yoilsho	1043	5	topical	topical	JJ
cord-006229-7yoilsho	1043	6	administration	administration	NN
cord-006229-7yoilsho	1043	7	of	of	IN
cord-006229-7yoilsho	1043	8	antiglaucoma	antiglaucoma	NNP
cord-006229-7yoilsho	1043	9	agents	agent	NNS
cord-006229-7yoilsho	1043	10	is	be	VBZ
cord-006229-7yoilsho	1043	11	still	still	RB
cord-006229-7yoilsho	1043	12	the	the	DT
cord-006229-7yoilsho	1043	13	mainstay	mainstay	NN
cord-006229-7yoilsho	1043	14	for	for	IN
cord-006229-7yoilsho	1043	15	glaucoma	glaucoma	NN
cord-006229-7yoilsho	1043	16	treatment	treatment	NN
cord-006229-7yoilsho	1043	17	.	.	.
cord-006229-7yoilsho	1044	1	1,2	1,2	LS
cord-006229-7yoilsho	1045	1	Although	although	IN
cord-006229-7yoilsho	1045	2	many	many	JJ
cord-006229-7yoilsho	1045	3	effective	effective	JJ
cord-006229-7yoilsho	1045	4	drugs	drug	NNS
cord-006229-7yoilsho	1045	5	exist	exist	VBP
cord-006229-7yoilsho	1045	6	,	,	,
cord-006229-7yoilsho	1045	7	the	the	DT
cord-006229-7yoilsho	1045	8	major	major	JJ
cord-006229-7yoilsho	1045	9	challenge	challenge	NN
cord-006229-7yoilsho	1045	10	is	be	VBZ
cord-006229-7yoilsho	1045	11	their	-PRON-	PRP$
cord-006229-7yoilsho	1045	12	efficient	efficient	JJ
cord-006229-7yoilsho	1045	13	intraocular	intraocular	JJ
cord-006229-7yoilsho	1045	14	delivery	delivery	NN
cord-006229-7yoilsho	1045	15	,	,	,
cord-006229-7yoilsho	1045	16	which	which	WDT
cord-006229-7yoilsho	1045	17	is	be	VBZ
cord-006229-7yoilsho	1045	18	estimated	estimate	VBN
cord-006229-7yoilsho	1045	19	to	to	TO
cord-006229-7yoilsho	1045	20	amount	amount	VB
cord-006229-7yoilsho	1045	21	to	to	IN
cord-006229-7yoilsho	1045	22	3	3	CD
cord-006229-7yoilsho	1046	1	The	the	DT
cord-006229-7yoilsho	1046	2	involvement	involvement	NN
cord-006229-7yoilsho	1046	3	of	of	IN
cord-006229-7yoilsho	1046	4	membrane	membrane	NN
cord-006229-7yoilsho	1046	5	drug	drug	NN
cord-006229-7yoilsho	1046	6	transporters	transporter	NNS
cord-006229-7yoilsho	1046	7	in	in	IN
cord-006229-7yoilsho	1046	8	the	the	DT
cord-006229-7yoilsho	1046	9	intraocular	intraocular	JJ
cord-006229-7yoilsho	1046	10	delivery	delivery	NN
cord-006229-7yoilsho	1046	11	of	of	IN
cord-006229-7yoilsho	1046	12	the	the	DT
cord-006229-7yoilsho	1046	13	widely	widely	RB
cord-006229-7yoilsho	1046	14	prescribed	prescribe	VBN
cord-006229-7yoilsho	1046	15	antiglaucoma	antiglaucoma	NNP
cord-006229-7yoilsho	1046	16	prostanoid	prostanoid	NNP
cord-006229-7yoilsho	1046	17	latanoprost	latanoprost	NNP
cord-006229-7yoilsho	1046	18	has	have	VBZ
cord-006229-7yoilsho	1046	19	been	be	VBN
cord-006229-7yoilsho	1046	20	described	describe	VBN
cord-006229-7yoilsho	1046	21	.	.	.
cord-006229-7yoilsho	1047	1	4	4	LS
cord-006229-7yoilsho	1048	1	However	however	RB
cord-006229-7yoilsho	1048	2	,	,	,
cord-006229-7yoilsho	1048	3	it	-PRON-	PRP
cord-006229-7yoilsho	1048	4	is	be	VBZ
cord-006229-7yoilsho	1048	5	currently	currently	RB
cord-006229-7yoilsho	1048	6	unknown	unknown	JJ
cord-006229-7yoilsho	1048	7	whether	whether	IN
cord-006229-7yoilsho	1048	8	the	the	DT
cord-006229-7yoilsho	1048	9	cationic	cationic	JJ
cord-006229-7yoilsho	1048	10	drugs	drug	NNS
cord-006229-7yoilsho	1048	11	brimonidine	brimonidine	NNP
cord-006229-7yoilsho	1048	12	and	and	CC
cord-006229-7yoilsho	1048	13	timolol	timolol	NNP
cord-006229-7yoilsho	1048	14	,	,	,
cord-006229-7yoilsho	1048	15	which	which	WDT
cord-006229-7yoilsho	1048	16	are	be	VBP
cord-006229-7yoilsho	1048	17	also	also	RB
cord-006229-7yoilsho	1048	18	commonly	commonly	RB
cord-006229-7yoilsho	1048	19	used	use	VBN
cord-006229-7yoilsho	1048	20	antiglaucoma	antiglaucoma	NNP
cord-006229-7yoilsho	1048	21	agents	agent	NNS
cord-006229-7yoilsho	1048	22	,	,	,
cord-006229-7yoilsho	1048	23	are	be	VBP
cord-006229-7yoilsho	1048	24	similarly	similarly	RB
cord-006229-7yoilsho	1048	25	transported	transport	VBN
cord-006229-7yoilsho	1048	26	by	by	IN
cord-006229-7yoilsho	1048	27	drug	drug	NN
cord-006229-7yoilsho	1048	28	transporters	transporter	NNS
cord-006229-7yoilsho	1048	29	and	and	CC
cord-006229-7yoilsho	1048	30	whether	whether	IN
cord-006229-7yoilsho	1048	31	these	these	DT
cord-006229-7yoilsho	1048	32	transporters	transporter	NNS
cord-006229-7yoilsho	1048	33	are	be	VBP
cord-006229-7yoilsho	1048	34	expressed	express	VBN
cord-006229-7yoilsho	1048	35	in	in	IN
cord-006229-7yoilsho	1048	36	human	human	JJ
cord-006229-7yoilsho	1048	37	eye	eye	NN
cord-006229-7yoilsho	1048	38	.	.	.
cord-006229-7yoilsho	1049	1	Brimonidine	Brimonidine	NNP
cord-006229-7yoilsho	1049	2	is	be	VBZ
cord-006229-7yoilsho	1049	3	an	an	DT
cord-006229-7yoilsho	1049	4	α	α	NN
cord-006229-7yoilsho	1049	5	2	2	CD
cord-006229-7yoilsho	1049	6	-adrenergic	-adrenergic	JJ
cord-006229-7yoilsho	1049	7	agonist	agonist	NN
cord-006229-7yoilsho	1049	8	,	,	,
cord-006229-7yoilsho	1049	9	which	which	WDT
cord-006229-7yoilsho	1049	10	inhibits	inhibit	VBZ
cord-006229-7yoilsho	1049	11	the	the	DT
cord-006229-7yoilsho	1049	12	activity	activity	NN
cord-006229-7yoilsho	1049	13	of	of	IN
cord-006229-7yoilsho	1049	14	the	the	DT
cord-006229-7yoilsho	1049	15	adenylate	adenylate	NN
cord-006229-7yoilsho	1049	16	cyclase	cyclase	NN
cord-006229-7yoilsho	1049	17	subsequently	subsequently	RB
cord-006229-7yoilsho	1049	18	leading	lead	VBG
cord-006229-7yoilsho	1049	19	to	to	IN
cord-006229-7yoilsho	1049	20	a	a	DT
cord-006229-7yoilsho	1049	21	reduced	reduce	VBN
cord-006229-7yoilsho	1049	22	production	production	NN
cord-006229-7yoilsho	1049	23	of	of	IN
cord-006229-7yoilsho	1049	24	aqueous	aqueous	JJ
cord-006229-7yoilsho	1049	25	humor	humor	NN
cord-006229-7yoilsho	1049	26	.	.	.
cord-006229-7yoilsho	1050	1	Timolol	Timolol	NNP
cord-006229-7yoilsho	1050	2	is	be	VBZ
cord-006229-7yoilsho	1050	3	a	a	DT
cord-006229-7yoilsho	1050	4	β	β	NN
cord-006229-7yoilsho	1050	5	-	-	HYPH
cord-006229-7yoilsho	1050	6	adrenergic	adrenergic	JJ
cord-006229-7yoilsho	1050	7	receptor	receptor	NN
cord-006229-7yoilsho	1050	8	antagonist	antagonist	NN
cord-006229-7yoilsho	1050	9	,	,	,
cord-006229-7yoilsho	1050	10	which	which	WDT
cord-006229-7yoilsho	1050	11	blocks	block	VBZ
cord-006229-7yoilsho	1050	12	β	β	NN
cord-006229-7yoilsho	1050	13	-	-	HYPH
cord-006229-7yoilsho	1050	14	receptors	receptor	NNS
cord-006229-7yoilsho	1050	15	on	on	IN
cord-006229-7yoilsho	1050	16	the	the	DT
cord-006229-7yoilsho	1050	17	ciliary	ciliary	NN
cord-006229-7yoilsho	1050	18	epithelium	epithelium	NN
cord-006229-7yoilsho	1050	19	also	also	RB
cord-006229-7yoilsho	1050	20	resulting	result	VBG
cord-006229-7yoilsho	1050	21	in	in	IN
cord-006229-7yoilsho	1050	22	a	a	DT
cord-006229-7yoilsho	1050	23	reduced	reduced	JJ
cord-006229-7yoilsho	1050	24	aqueous	aqueous	JJ
cord-006229-7yoilsho	1050	25	humor	humor	NN
cord-006229-7yoilsho	1050	26	production	production	NN
cord-006229-7yoilsho	1050	27	.	.	.
cord-006229-7yoilsho	1051	1	The	the	DT
cord-006229-7yoilsho	1051	2	aim	aim	NN
cord-006229-7yoilsho	1051	3	of	of	IN
cord-006229-7yoilsho	1051	4	the	the	DT
cord-006229-7yoilsho	1051	5	present	present	JJ
cord-006229-7yoilsho	1051	6	study	study	NN
cord-006229-7yoilsho	1051	7	was	be	VBD
cord-006229-7yoilsho	1051	8	to	to	TO
cord-006229-7yoilsho	1051	9	determine	determine	VB
cord-006229-7yoilsho	1051	10	whether	whether	IN
cord-006229-7yoilsho	1051	11	brimonidine	brimonidine	NN
cord-006229-7yoilsho	1051	12	and	and	CC
cord-006229-7yoilsho	1051	13	timolol	timolol	NNP
cord-006229-7yoilsho	1051	14	are	be	VBP
cord-006229-7yoilsho	1051	15	substrates	substrate	NNS
cord-006229-7yoilsho	1051	16	of	of	IN
cord-006229-7yoilsho	1051	17	the	the	DT
cord-006229-7yoilsho	1051	18	organic	organic	NNP
cord-006229-7yoilsho	1051	19	cation	cation	NN
cord-006229-7yoilsho	1051	20	drug	drug	NN
cord-006229-7yoilsho	1051	21	transporters	transporter	NNS
cord-006229-7yoilsho	1051	22	OCT1	OCT1	NNP
cord-006229-7yoilsho	1051	23	(	(	-LRB-
cord-006229-7yoilsho	1051	24	encoded	encode	VBN
cord-006229-7yoilsho	1051	25	by	by	IN
cord-006229-7yoilsho	1051	26	SLC22A1	SLC22A1	NNP
cord-006229-7yoilsho	1051	27	)	)	-RRB-
cord-006229-7yoilsho	1051	28	,	,	,
cord-006229-7yoilsho	1051	29	OCT2	OCT2	NNP
cord-006229-7yoilsho	1051	30	(	(	-LRB-
cord-006229-7yoilsho	1051	31	SLC22A2	slc22a2	NN
cord-006229-7yoilsho	1051	32	)	)	-RRB-
cord-006229-7yoilsho	1051	33	,	,	,
cord-006229-7yoilsho	1051	34	OCT3	OCT3	NNP
cord-006229-7yoilsho	1051	35	(	(	-LRB-
cord-006229-7yoilsho	1051	36	SLC22A3	slc22a3	NN
cord-006229-7yoilsho	1051	37	)	)	-RRB-
cord-006229-7yoilsho	1051	38	and	and	CC
cord-006229-7yoilsho	1051	39	MATE1	MATE1	NNS
cord-006229-7yoilsho	1051	40	(	(	-LRB-
cord-006229-7yoilsho	1051	41	SLC47A1	slc47a1	NN
cord-006229-7yoilsho	1051	42	)	)	-RRB-
cord-006229-7yoilsho	1051	43	.	.	.
cord-006229-7yoilsho	1052	1	A	a	DT
cord-006229-7yoilsho	1052	2	further	further	JJ
cord-006229-7yoilsho	1052	3	aim	aim	NN
cord-006229-7yoilsho	1052	4	was	be	VBD
cord-006229-7yoilsho	1052	5	to	to	TO
cord-006229-7yoilsho	1052	6	investigate	investigate	VB
cord-006229-7yoilsho	1052	7	whether	whether	IN
cord-006229-7yoilsho	1052	8	these	these	DT
cord-006229-7yoilsho	1052	9	transporters	transporter	NNS
cord-006229-7yoilsho	1052	10	are	be	VBP
cord-006229-7yoilsho	1052	11	localized	localize	VBN
cord-006229-7yoilsho	1052	12	in	in	IN
cord-006229-7yoilsho	1052	13	different	different	JJ
cord-006229-7yoilsho	1052	14	human	human	JJ
cord-006229-7yoilsho	1052	15	eye	eye	NN
cord-006229-7yoilsho	1052	16	substructures	substructure	NNS
cord-006229-7yoilsho	1052	17	.	.	.
cord-006229-7yoilsho	1053	1	Experimental	experimental	JJ
cord-006229-7yoilsho	1053	2	design	design	NN
cord-006229-7yoilsho	1053	3	:	:	:
cord-006229-7yoilsho	1054	1	Transport	transport	NN
cord-006229-7yoilsho	1054	2	of	of	IN
cord-006229-7yoilsho	1054	3	brimonidine	brimonidine	NNP
cord-006229-7yoilsho	1054	4	and	and	CC
cord-006229-7yoilsho	1054	5	timolol	timolol	NNP
cord-006229-7yoilsho	1054	6	was	be	VBD
cord-006229-7yoilsho	1054	7	studied	study	VBN
cord-006229-7yoilsho	1054	8	using	use	VBG
cord-006229-7yoilsho	1054	9	the	the	DT
cord-006229-7yoilsho	1054	10	mammalian	mammalian	JJ
cord-006229-7yoilsho	1054	11	cell	cell	NN
cord-006229-7yoilsho	1054	12	line	line	NN
cord-006229-7yoilsho	1054	13	HEK293	HEK293	NNP
cord-006229-7yoilsho	1054	14	stably	stably	RB
cord-006229-7yoilsho	1054	15	expressing	express	VBG
cord-006229-7yoilsho	1054	16	the	the	DT
cord-006229-7yoilsho	1054	17	organic	organic	JJ
cord-006229-7yoilsho	1054	18	cation	cation	NN
cord-006229-7yoilsho	1054	19	transporters	transporter	NNS
cord-006229-7yoilsho	1054	20	OCT1	OCT1	NNP
cord-006229-7yoilsho	1054	21	,	,	,
cord-006229-7yoilsho	1054	22	OCT2	OCT2	NNP
cord-006229-7yoilsho	1054	23	,	,	,
cord-006229-7yoilsho	1054	24	OCT3	OCT3	NNP
cord-006229-7yoilsho	1054	25	or	or	CC
cord-006229-7yoilsho	1054	26	MATE1	MATE1	NNS
cord-006229-7yoilsho	1054	27	.	.	.
cord-006229-7yoilsho	1055	1	5	5	LS
cord-006229-7yoilsho	1056	1	Intracellular	Intracellular	NNP
cord-006229-7yoilsho	1056	2	accumulation	accumulation	NN
cord-006229-7yoilsho	1056	3	of	of	IN
cord-006229-7yoilsho	1056	4	brimonidine	brimonidine	NNP
cord-006229-7yoilsho	1056	5	and	and	CC
cord-006229-7yoilsho	1056	6	timolol	timolol	NNP
cord-006229-7yoilsho	1056	7	was	be	VBD
cord-006229-7yoilsho	1056	8	analyzed	analyze	VBN
cord-006229-7yoilsho	1056	9	by	by	IN
cord-006229-7yoilsho	1056	10	mass	mass	NN
cord-006229-7yoilsho	1056	11	spectrometry	spectrometry	NN
cord-006229-7yoilsho	1056	12	.	.	.
cord-006229-7yoilsho	1057	1	Immunohistochemistry	immunohistochemistry	NN
cord-006229-7yoilsho	1057	2	and	and	CC
cord-006229-7yoilsho	1057	3	immunofluorescence	immunofluorescence	NN
cord-006229-7yoilsho	1057	4	experiments	experiment	NNS
cord-006229-7yoilsho	1057	5	were	be	VBD
cord-006229-7yoilsho	1057	6	performed	perform	VBN
cord-006229-7yoilsho	1057	7	to	to	TO
cord-006229-7yoilsho	1057	8	study	study	VB
cord-006229-7yoilsho	1057	9	the	the	DT
cord-006229-7yoilsho	1057	10	localization	localization	NN
cord-006229-7yoilsho	1057	11	of	of	IN
cord-006229-7yoilsho	1057	12	these	these	DT
cord-006229-7yoilsho	1057	13	transporters	transporter	NNS
cord-006229-7yoilsho	1057	14	in	in	IN
cord-006229-7yoilsho	1057	15	different	different	JJ
cord-006229-7yoilsho	1057	16	substructures	substructure	NNS
cord-006229-7yoilsho	1057	17	from	from	IN
cord-006229-7yoilsho	1057	18	glaucomatous	glaucomatous	JJ
cord-006229-7yoilsho	1057	19	and	and	CC
cord-006229-7yoilsho	1057	20	non	non	JJ
cord-006229-7yoilsho	1057	21	-	-	JJ
cord-006229-7yoilsho	1057	22	glaucomatous	glaucomatous	JJ
cord-006229-7yoilsho	1057	23	human	human	JJ
cord-006229-7yoilsho	1057	24	eyes	eye	NNS
cord-006229-7yoilsho	1057	25	.	.	.
cord-006229-7yoilsho	1058	1	Results	result	NNS
cord-006229-7yoilsho	1058	2	:	:	:
cord-006229-7yoilsho	1059	1	Uptake	uptake	NN
cord-006229-7yoilsho	1059	2	experiments	experiment	NNS
cord-006229-7yoilsho	1059	3	revealed	reveal	VBD
cord-006229-7yoilsho	1059	4	that	that	IN
cord-006229-7yoilsho	1059	5	brimonidine	brimonidine	NNP
cord-006229-7yoilsho	1059	6	is	be	VBZ
cord-006229-7yoilsho	1059	7	transported	transport	VBN
cord-006229-7yoilsho	1059	8	by	by	IN
cord-006229-7yoilsho	1059	9	OCT2	OCT2	NNP
cord-006229-7yoilsho	1059	10	and	and	CC
cord-006229-7yoilsho	1059	11	MATE1	MATE1	NNS
cord-006229-7yoilsho	1059	12	in	in	IN
cord-006229-7yoilsho	1059	13	a	a	DT
cord-006229-7yoilsho	1059	14	time	time	NN
cord-006229-7yoilsho	1059	15	-	-	HYPH
cord-006229-7yoilsho	1059	16	and	and	CC
cord-006229-7yoilsho	1059	17	concentration	concentration	NN
cord-006229-7yoilsho	1059	18	-	-	HYPH
cord-006229-7yoilsho	1059	19	dependent	dependent	JJ
cord-006229-7yoilsho	1059	20	manner	manner	NN
cord-006229-7yoilsho	1059	21	,	,	,
cord-006229-7yoilsho	1059	22	but	but	CC
cord-006229-7yoilsho	1059	23	not	not	RB
cord-006229-7yoilsho	1059	24	by	by	IN
cord-006229-7yoilsho	1059	25	OCT1	OCT1	NNP
cord-006229-7yoilsho	1059	26	or	or	CC
cord-006229-7yoilsho	1059	27	OCT3	OCT3	NNP
cord-006229-7yoilsho	1059	28	.	.	.
cord-006229-7yoilsho	1060	1	Timolol	Timolol	NNP
cord-006229-7yoilsho	1060	2	is	be	VBZ
cord-006229-7yoilsho	1060	3	only	only	RB
cord-006229-7yoilsho	1060	4	transported	transport	VBN
cord-006229-7yoilsho	1060	5	by	by	IN
cord-006229-7yoilsho	1060	6	MATE1	MATE1	NNS
cord-006229-7yoilsho	1060	7	,	,	,
cord-006229-7yoilsho	1060	8	but	but	CC
cord-006229-7yoilsho	1060	9	not	not	RB
cord-006229-7yoilsho	1060	10	by	by	IN
cord-006229-7yoilsho	1060	11	the	the	DT
cord-006229-7yoilsho	1060	12	OCTs	oct	NNS
cord-006229-7yoilsho	1060	13	.	.	.
cord-006229-7yoilsho	1061	1	As	as	IN
cord-006229-7yoilsho	1061	2	shown	show	VBN
cord-006229-7yoilsho	1061	3	by	by	IN
cord-006229-7yoilsho	1061	4	immunolocalization	immunolocalization	NN
cord-006229-7yoilsho	1061	5	studies	study	NNS
cord-006229-7yoilsho	1061	6	,	,	,
cord-006229-7yoilsho	1061	7	the	the	DT
cord-006229-7yoilsho	1061	8	OCT2	OCT2	NNP
cord-006229-7yoilsho	1061	9	and	and	CC
cord-006229-7yoilsho	1061	10	MATE1	mate1	NN
cord-006229-7yoilsho	1061	11	transporter	transporter	NN
cord-006229-7yoilsho	1061	12	proteins	protein	NNS
cord-006229-7yoilsho	1061	13	were	be	VBD
cord-006229-7yoilsho	1061	14	expressed	express	VBN
cord-006229-7yoilsho	1061	15	in	in	IN
cord-006229-7yoilsho	1061	16	all	all	DT
cord-006229-7yoilsho	1061	17	anterior	anterior	JJ
cord-006229-7yoilsho	1061	18	eye	eye	NN
cord-006229-7yoilsho	1061	19	substructures	substructure	NNS
cord-006229-7yoilsho	1061	20	of	of	IN
cord-006229-7yoilsho	1061	21	non	non	JJ
cord-006229-7yoilsho	1061	22	-	-	JJ
cord-006229-7yoilsho	1061	23	glaucomatous	glaucomatous	JJ
cord-006229-7yoilsho	1061	24	and	and	CC
cord-006229-7yoilsho	1061	25	glaucomatous	glaucomatous	JJ
cord-006229-7yoilsho	1061	26	eyes	eye	NNS
cord-006229-7yoilsho	1061	27	,	,	,
cord-006229-7yoilsho	1061	28	i.e.	i.e.	FW
cord-006229-7yoilsho	1061	29	the	the	DT
cord-006229-7yoilsho	1061	30	cornea	cornea	NN
cord-006229-7yoilsho	1061	31	,	,	,
cord-006229-7yoilsho	1061	32	the	the	DT
cord-006229-7yoilsho	1061	33	conjunctiva	conjunctiva	NN
cord-006229-7yoilsho	1061	34	and	and	CC
cord-006229-7yoilsho	1061	35	the	the	DT
cord-006229-7yoilsho	1061	36	ciliary	ciliary	NN
cord-006229-7yoilsho	1061	37	body	body	NN
cord-006229-7yoilsho	1061	38	.	.	.
cord-006229-7yoilsho	1062	1	Conclusion	conclusion	NN
cord-006229-7yoilsho	1062	2	:	:	:
cord-006229-7yoilsho	1063	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	1063	2	data	datum	NNS
cord-006229-7yoilsho	1063	3	demonstrate	demonstrate	VBP
cord-006229-7yoilsho	1063	4	that	that	IN
cord-006229-7yoilsho	1063	5	OCT2	OCT2	NNP
cord-006229-7yoilsho	1063	6	and	and	CC
cord-006229-7yoilsho	1063	7	MATE1	MATE1	NNS
cord-006229-7yoilsho	1063	8	may	may	MD
cord-006229-7yoilsho	1063	9	play	play	VB
cord-006229-7yoilsho	1063	10	a	a	DT
cord-006229-7yoilsho	1063	11	role	role	NN
cord-006229-7yoilsho	1063	12	in	in	IN
cord-006229-7yoilsho	1063	13	the	the	DT
cord-006229-7yoilsho	1063	14	ocular	ocular	JJ
cord-006229-7yoilsho	1063	15	disposition	disposition	NN
cord-006229-7yoilsho	1063	16	of	of	IN
cord-006229-7yoilsho	1063	17	the	the	DT
cord-006229-7yoilsho	1063	18	antiglaucoma	antiglaucoma	NNP
cord-006229-7yoilsho	1063	19	drugs	drug	NNS
cord-006229-7yoilsho	1063	20	brimonidine	brimonidine	NNP
cord-006229-7yoilsho	1063	21	and	and	CC
cord-006229-7yoilsho	1063	22	timolol	timolol	NNP
cord-006229-7yoilsho	1063	23	and	and	CC
cord-006229-7yoilsho	1063	24	may	may	MD
cord-006229-7yoilsho	1063	25	contribute	contribute	VB
cord-006229-7yoilsho	1063	26	to	to	IN
cord-006229-7yoilsho	1063	27	interindividual	interindividual	JJ
cord-006229-7yoilsho	1063	28	variability	variability	NN
cord-006229-7yoilsho	1063	29	of	of	IN
cord-006229-7yoilsho	1063	30	drug	drug	NN
cord-006229-7yoilsho	1063	31	concentrations	concentration	NNS
cord-006229-7yoilsho	1063	32	and	and	CC
cord-006229-7yoilsho	1063	33	effects	effect	NNS
cord-006229-7yoilsho	1063	34	.	.	.
cord-006229-7yoilsho	1064	1	References	reference	NNS
cord-006229-7yoilsho	1064	2	:	:	:
cord-006229-7yoilsho	1064	3	1	1	CD
cord-006229-7yoilsho	1064	4	.	.	.
cord-006229-7yoilsho	1065	1	Zhang	Zhang	NNP
cord-006229-7yoilsho	1065	2	et	et	NNP
cord-006229-7yoilsho	1065	3	al	al	NNP
cord-006229-7yoilsho	1065	4	.	.	.
cord-006229-7yoilsho	1066	1	,	,	,
cord-006229-7yoilsho	1066	2	Nat	Nat	NNP
cord-006229-7yoilsho	1066	3	Rev	Rev	NNP
cord-006229-7yoilsho	1066	4	Drug	Drug	NNP
cord-006229-7yoilsho	1066	5	Discov	Discov	NNP
cord-006229-7yoilsho	1066	6	.	.	.
cord-006229-7yoilsho	1067	1	2012	2012	CD
cord-006229-7yoilsho	1068	1	Jun	Jun	NNP
cord-006229-7yoilsho	1068	2	15	15	CD
cord-006229-7yoilsho	1068	3	;	;	:
cord-006229-7yoilsho	1068	4	11(7	11(7	CD
cord-006229-7yoilsho	1068	5	)	)	-RRB-
cord-006229-7yoilsho	1068	6	:	:	:
cord-006229-7yoilsho	1068	7	541	541	CD
cord-006229-7yoilsho	1068	8	-	-	SYM
cord-006229-7yoilsho	1068	9	59	59	CD
cord-006229-7yoilsho	1068	10	.	.	.
cord-006229-7yoilsho	1069	1	2	2	LS
cord-006229-7yoilsho	1069	2	.	.	.
cord-006229-7yoilsho	1070	1	Lavik	Lavik	NNP
cord-006229-7yoilsho	1070	2	et	et	NNP
cord-006229-7yoilsho	1070	3	al	al	NNP
cord-006229-7yoilsho	1070	4	.	.	NNP
cord-006229-7yoilsho	1070	5	,	,	,
cord-006229-7yoilsho	1070	6	Eye	Eye	NNP
cord-006229-7yoilsho	1070	7	(	(	-LRB-
cord-006229-7yoilsho	1070	8	Lond	Lond	NNP
cord-006229-7yoilsho	1070	9	)	)	-RRB-
cord-006229-7yoilsho	1070	10	.	.	.
cord-006229-7yoilsho	1071	1	2011	2011	CD
cord-006229-7yoilsho	1072	1	May	May	NNP
cord-006229-7yoilsho	1072	2	;	;	:
cord-006229-7yoilsho	1072	3	25(5):578	25(5):578	CD
cord-006229-7yoilsho	1072	4	-	-	SYM
cord-006229-7yoilsho	1072	5	86	86	CD
cord-006229-7yoilsho	1072	6	.	.	.
cord-006229-7yoilsho	1072	7	3	3	CD
cord-006229-7yoilsho	1072	8	.	.	.
cord-006229-7yoilsho	1073	1	Gaudana	Gaudana	NNP
cord-006229-7yoilsho	1073	2	et	et	FW
cord-006229-7yoilsho	1073	3	al	al	NNP
cord-006229-7yoilsho	1073	4	.	.	.
cord-006229-7yoilsho	1074	1	,	,	,
cord-006229-7yoilsho	1074	2	Pharm	Pharm	NNP
cord-006229-7yoilsho	1074	3	Res	Res	NNP
cord-006229-7yoilsho	1074	4	.	.	.
cord-006229-7yoilsho	1075	1	2009	2009	CD
cord-006229-7yoilsho	1075	2	May	May	NNP
cord-006229-7yoilsho	1075	3	;	;	:
cord-006229-7yoilsho	1075	4	26(5):1197	26(5):1197	NNP
cord-006229-7yoilsho	1075	5	-216	-216	NN
cord-006229-7yoilsho	1075	6	.	.	.
cord-006229-7yoilsho	1076	1	4	4	LS
cord-006229-7yoilsho	1076	2	.	.	.
cord-006229-7yoilsho	1077	1	Kraft	Kraft	NNP
cord-006229-7yoilsho	1077	2	et	et	NNP
cord-006229-7yoilsho	1077	3	al	al	NNP
cord-006229-7yoilsho	1077	4	.	.	.
cord-006229-7yoilsho	1078	1	,	,	,
cord-006229-7yoilsho	1078	2	Invest	invest	VB
cord-006229-7yoilsho	1078	3	Ophthalmol	Ophthalmol	NNP
cord-006229-7yoilsho	1079	1	Vis	Vis	NNP
cord-006229-7yoilsho	1079	2	Sci	Sci	NNP
cord-006229-7yoilsho	1079	3	.	.	.
cord-006229-7yoilsho	1080	1	2010	2010	CD
cord-006229-7yoilsho	1080	2	51(5):2504	51(5):2504	CD
cord-006229-7yoilsho	1080	3	-11	-11	XX
cord-006229-7yoilsho	1080	4	.	.	.
cord-006229-7yoilsho	1081	1	5	5	LS
cord-006229-7yoilsho	1081	2	.	.	.
cord-006229-7yoilsho	1082	1	Nies	Nies	NNP
cord-006229-7yoilsho	1082	2	et	et	NNP
cord-006229-7yoilsho	1082	3	al	al	NNP
cord-006229-7yoilsho	1082	4	.	.	NNP
cord-006229-7yoilsho	1082	5	,	,	,
cord-006229-7yoilsho	1083	1	PLoS	PLoS	NNP
cord-006229-7yoilsho	1083	2	One	one	CD
cord-006229-7yoilsho	1083	3	.	.	.
cord-006229-7yoilsho	1083	4	2011	2011	CD
cord-006229-7yoilsho	1083	5	6(7	6(7	CD
cord-006229-7yoilsho	1083	6	)	)	-RRB-
cord-006229-7yoilsho	1083	7	:	:	:
cord-006229-7yoilsho	1084	1	e22163	e22163	NNP
cord-006229-7yoilsho	1084	2	.	.	.
cord-006229-7yoilsho	1085	1	Supported	support	VBN
cord-006229-7yoilsho	1085	2	by	by	IN
cord-006229-7yoilsho	1085	3	the	the	DT
cord-006229-7yoilsho	1085	4	Robert	Robert	NNP
cord-006229-7yoilsho	1085	5	Bosch	Bosch	NNP
cord-006229-7yoilsho	1085	6	Foundation	Foundation	NNP
cord-006229-7yoilsho	1085	7	,	,	,
cord-006229-7yoilsho	1085	8	Stuttgart	Stuttgart	NNP
cord-006229-7yoilsho	1085	9	,	,	,
cord-006229-7yoilsho	1085	10	Germany	Germany	NNP
cord-006229-7yoilsho	1085	11	.	.	.
cord-006229-7yoilsho	1086	1	Immature	immature	JJ
cord-006229-7yoilsho	1086	2	platelet	platelet	NN
cord-006229-7yoilsho	1086	3	count	count	NN
cord-006229-7yoilsho	1086	4	or	or	CC
cord-006229-7yoilsho	1086	5	immature	immature	JJ
cord-006229-7yoilsho	1086	6	platelet	platelet	NN
cord-006229-7yoilsho	1086	7	fraction	fraction	NN
cord-006229-7yoilsho	1086	8	as	as	IN
cord-006229-7yoilsho	1086	9	optimal	optimal	JJ
cord-006229-7yoilsho	1086	10	predictor	predictor	NN
cord-006229-7yoilsho	1086	11	of	of	IN
cord-006229-7yoilsho	1086	12	antiplatelet	antiplatelet	JJ
cord-006229-7yoilsho	1086	13	response	response	NN
cord-006229-7yoilsho	1086	14	to	to	IN
cord-006229-7yoilsho	1086	15	thienopyridine	thienopyridine	NN
cord-006229-7yoilsho	1086	16	therapy	therapy	NN
cord-006229-7yoilsho	1086	17	C.	C.	NNP
cord-006229-7yoilsho	1086	18	Stratz	Stratz	NNP
cord-006229-7yoilsho	1086	19	1	1	CD
cord-006229-7yoilsho	1087	1	,	,	,
cord-006229-7yoilsho	1087	2	T.	T.	NNP
cord-006229-7yoilsho	1087	3	Nuehrenberg	Nuehrenberg	NNP
cord-006229-7yoilsho	1087	4	Background	Background	NNP
cord-006229-7yoilsho	1087	5	:	:	:
cord-006229-7yoilsho	1088	1	Previous	previous	JJ
cord-006229-7yoilsho	1088	2	data	datum	NNS
cord-006229-7yoilsho	1088	3	suggest	suggest	VBP
cord-006229-7yoilsho	1088	4	that	that	IN
cord-006229-7yoilsho	1088	5	reticulated	reticulated	JJ
cord-006229-7yoilsho	1088	6	platelets	platelet	NNS
cord-006229-7yoilsho	1088	7	impact	impact	VBP
cord-006229-7yoilsho	1088	8	significantly	significantly	RB
cord-006229-7yoilsho	1088	9	on	on	IN
cord-006229-7yoilsho	1088	10	antiplatelet	antiplatelet	JJ
cord-006229-7yoilsho	1088	11	response	response	NN
cord-006229-7yoilsho	1088	12	to	to	IN
cord-006229-7yoilsho	1088	13	thienopyridines	thienopyridines	NNP
cord-006229-7yoilsho	1088	14	.	.	.
cord-006229-7yoilsho	1089	1	It	-PRON-	PRP
cord-006229-7yoilsho	1089	2	is	be	VBZ
cord-006229-7yoilsho	1089	3	unknown	unknown	JJ
cord-006229-7yoilsho	1089	4	which	which	WDT
cord-006229-7yoilsho	1089	5	of	of	IN
cord-006229-7yoilsho	1089	6	the	the	DT
cord-006229-7yoilsho	1089	7	parameters	parameter	NNS
cord-006229-7yoilsho	1089	8	describing	describe	VBG
cord-006229-7yoilsho	1089	9	reticulated	reticulated	JJ
cord-006229-7yoilsho	1089	10	platelets	platelet	NNS
cord-006229-7yoilsho	1089	11	is	be	VBZ
cord-006229-7yoilsho	1089	12	the	the	DT
cord-006229-7yoilsho	1089	13	optimal	optimal	JJ
cord-006229-7yoilsho	1089	14	predictor	predictor	NN
cord-006229-7yoilsho	1089	15	of	of	IN
cord-006229-7yoilsho	1089	16	antiplatelet	antiplatelet	JJ
cord-006229-7yoilsho	1089	17	response	response	NN
cord-006229-7yoilsho	1089	18	to	to	IN
cord-006229-7yoilsho	1089	19	thienopyridine	thienopyridine	NN
cord-006229-7yoilsho	1089	20	therapy	therapy	NN
cord-006229-7yoilsho	1089	21	.	.	.
cord-006229-7yoilsho	1090	1	Methods	method	NNS
cord-006229-7yoilsho	1090	2	:	:	:
cord-006229-7yoilsho	1090	3	This	this	DT
cord-006229-7yoilsho	1090	4	study	study	NN
cord-006229-7yoilsho	1090	5	is	be	VBZ
cord-006229-7yoilsho	1090	6	a	a	DT
cord-006229-7yoilsho	1090	7	prespecified	prespecified	JJ
cord-006229-7yoilsho	1090	8	subanalysis	subanalysis	NN
cord-006229-7yoilsho	1090	9	of	of	IN
cord-006229-7yoilsho	1090	10	the	the	DT
cord-006229-7yoilsho	1090	11	ExcelsiorLOAD	ExcelsiorLOAD	NNP
cord-006229-7yoilsho	1090	12	trial	trial	NN
cord-006229-7yoilsho	1090	13	that	that	WDT
cord-006229-7yoilsho	1090	14	randomized	randomize	VBD
cord-006229-7yoilsho	1090	15	elective	elective	JJ
cord-006229-7yoilsho	1090	16	patients	patient	NNS
cord-006229-7yoilsho	1090	17	undergoing	undergo	VBG
cord-006229-7yoilsho	1090	18	coronary	coronary	JJ
cord-006229-7yoilsho	1090	19	stenting	stenting	NN
cord-006229-7yoilsho	1090	20	to	to	IN
cord-006229-7yoilsho	1090	21	loading	load	VBG
cord-006229-7yoilsho	1090	22	with	with	IN
cord-006229-7yoilsho	1090	23	clopidogrel	clopidogrel	NNP
cord-006229-7yoilsho	1090	24	600	600	CD
cord-006229-7yoilsho	1090	25	mg	mg	NNP
cord-006229-7yoilsho	1090	26	,	,	,
cord-006229-7yoilsho	1090	27	prasugrel	prasugrel	NNP
cord-006229-7yoilsho	1090	28	30	30	CD
cord-006229-7yoilsho	1090	29	mg	mg	NN
cord-006229-7yoilsho	1090	30	or	or	CC
cord-006229-7yoilsho	1090	31	prasugrel	prasugrel	NNP
cord-006229-7yoilsho	1090	32	60	60	CD
cord-006229-7yoilsho	1090	33	mg	mg	NNP
cord-006229-7yoilsho	1090	34	(	(	-LRB-
cord-006229-7yoilsho	1090	35	n=300	n=300	NNP
cord-006229-7yoilsho	1090	36	)	)	-RRB-
cord-006229-7yoilsho	1090	37	.	.	.
cord-006229-7yoilsho	1091	1	ADP	ADP	NNP
cord-006229-7yoilsho	1091	2	-	-	HYPH
cord-006229-7yoilsho	1091	3	induced	induce	VBN
cord-006229-7yoilsho	1091	4	platelet	platelet	NN
cord-006229-7yoilsho	1091	5	reactivity	reactivity	NN
cord-006229-7yoilsho	1091	6	was	be	VBD
cord-006229-7yoilsho	1091	7	assessed	assess	VBN
cord-006229-7yoilsho	1091	8	by	by	IN
cord-006229-7yoilsho	1091	9	impedance	impedance	NN
cord-006229-7yoilsho	1091	10	aggregometry	aggregometry	NN
cord-006229-7yoilsho	1091	11	before	before	IN
cord-006229-7yoilsho	1091	12	loading	loading	NN
cord-006229-7yoilsho	1091	13	(	(	-LRB-
cord-006229-7yoilsho	1091	14	=	=	SYM
cord-006229-7yoilsho	1091	15	intrinsic	intrinsic	JJ
cord-006229-7yoilsho	1091	16	platelet	platelet	NN
cord-006229-7yoilsho	1091	17	reactivity	reactivity	NN
cord-006229-7yoilsho	1091	18	)	)	-RRB-
cord-006229-7yoilsho	1091	19	and	and	CC
cord-006229-7yoilsho	1091	20	on	on	IN
cord-006229-7yoilsho	1091	21	day	day	NN
cord-006229-7yoilsho	1091	22	1	1	CD
cord-006229-7yoilsho	1091	23	after	after	IN
cord-006229-7yoilsho	1091	24	loading	load	VBG
cord-006229-7yoilsho	1091	25	.	.	.
cord-006229-7yoilsho	1092	1	Multiple	multiple	JJ
cord-006229-7yoilsho	1092	2	parameters	parameter	NNS
cord-006229-7yoilsho	1092	3	of	of	IN
cord-006229-7yoilsho	1092	4	reticulated	reticulated	JJ
cord-006229-7yoilsho	1092	5	platelets	platelet	NNS
cord-006229-7yoilsho	1092	6	were	be	VBD
cord-006229-7yoilsho	1092	7	assessed	assess	VBN
cord-006229-7yoilsho	1092	8	by	by	IN
cord-006229-7yoilsho	1092	9	an	an	DT
cord-006229-7yoilsho	1092	10	automated	automated	JJ
cord-006229-7yoilsho	1092	11	whole	whole	JJ
cord-006229-7yoilsho	1092	12	blood	blood	NN
cord-006229-7yoilsho	1092	13	flow	flow	NN
cord-006229-7yoilsho	1092	14	cytometer	cytometer	NN
cord-006229-7yoilsho	1092	15	:	:	:
cord-006229-7yoilsho	1092	16	immature	immature	JJ
cord-006229-7yoilsho	1092	17	platelet	platelet	NN
cord-006229-7yoilsho	1092	18	fraction	fraction	NN
cord-006229-7yoilsho	1093	1	(	(	-LRB-
cord-006229-7yoilsho	1093	2	IPF	IPF	NNP
cord-006229-7yoilsho	1093	3	,	,	,
cord-006229-7yoilsho	1093	4	proportion	proportion	NN
cord-006229-7yoilsho	1093	5	of	of	IN
cord-006229-7yoilsho	1093	6	reticulated	reticulated	JJ
cord-006229-7yoilsho	1093	7	platelet	platelet	NN
cord-006229-7yoilsho	1093	8	of	of	IN
cord-006229-7yoilsho	1093	9	the	the	DT
cord-006229-7yoilsho	1093	10	whole	whole	JJ
cord-006229-7yoilsho	1093	11	platelet	platelet	NN
cord-006229-7yoilsho	1093	12	pool	pool	NN
cord-006229-7yoilsho	1093	13	)	)	-RRB-
cord-006229-7yoilsho	1093	14	,	,	,
cord-006229-7yoilsho	1093	15	highly	highly	RB
cord-006229-7yoilsho	1093	16	immature	immature	JJ
cord-006229-7yoilsho	1093	17	platelet	platelet	NN
cord-006229-7yoilsho	1093	18	fraction	fraction	NN
cord-006229-7yoilsho	1093	19	(	(	-LRB-
cord-006229-7yoilsho	1093	20	hIPF	hIPF	NNP
cord-006229-7yoilsho	1093	21	)	)	-RRB-
cord-006229-7yoilsho	1093	22	,	,	,
cord-006229-7yoilsho	1093	23	absolute	absolute	DT
cord-006229-7yoilsho	1093	24	immature	immature	JJ
cord-006229-7yoilsho	1093	25	platelet	platelet	NN
cord-006229-7yoilsho	1093	26	count	count	NN
cord-006229-7yoilsho	1093	27	(	(	-LRB-
cord-006229-7yoilsho	1093	28	IPC	IPC	NNP
cord-006229-7yoilsho	1093	29	)	)	-RRB-
cord-006229-7yoilsho	1093	30	.	.	.
cord-006229-7yoilsho	1094	1	Results	result	NNS
cord-006229-7yoilsho	1094	2	:	:	:
cord-006229-7yoilsho	1095	1	Each	each	DT
cord-006229-7yoilsho	1095	2	parameter	parameter	NN
cord-006229-7yoilsho	1095	3	of	of	IN
cord-006229-7yoilsho	1095	4	reticulated	reticulated	JJ
cord-006229-7yoilsho	1095	5	platelets	platelet	NNS
cord-006229-7yoilsho	1095	6	correlated	correlate	VBD
cord-006229-7yoilsho	1095	7	significantly	significantly	RB
cord-006229-7yoilsho	1095	8	with	with	IN
cord-006229-7yoilsho	1095	9	ADPinduced	adpinduced	JJ
cord-006229-7yoilsho	1095	10	platelet	platelet	NN
cord-006229-7yoilsho	1095	11	reactivity	reactivity	NN
cord-006229-7yoilsho	1095	12	:	:	:
cord-006229-7yoilsho	1095	13	IPF	IPF	NNP
cord-006229-7yoilsho	1095	14	(	(	-LRB-
cord-006229-7yoilsho	1095	15	r	r	NN
cord-006229-7yoilsho	1095	16	s	s	NN
cord-006229-7yoilsho	1095	17	=	=	SYM
cord-006229-7yoilsho	1095	18	0.18	0.18	CD
cord-006229-7yoilsho	1095	19	;	;	:
cord-006229-7yoilsho	1095	20	p=0.002	p=0.002	NNP
cord-006229-7yoilsho	1095	21	)	)	-RRB-
cord-006229-7yoilsho	1095	22	,	,	,
cord-006229-7yoilsho	1095	23	hIPF	hIPF	NNP
cord-006229-7yoilsho	1096	1	(	(	-LRB-
cord-006229-7yoilsho	1096	2	r	r	NNP
cord-006229-7yoilsho	1096	3	s	s	NN
cord-006229-7yoilsho	1096	4	=	=	SYM
cord-006229-7yoilsho	1096	5	0.18	0.18	CD
cord-006229-7yoilsho	1096	6	;	;	:
cord-006229-7yoilsho	1096	7	p=0.002	p=0.002	NNP
cord-006229-7yoilsho	1096	8	)	)	-RRB-
cord-006229-7yoilsho	1096	9	,	,	,
cord-006229-7yoilsho	1096	10	IPC	IPC	NNP
cord-006229-7yoilsho	1096	11	r	r	NNP
cord-006229-7yoilsho	1096	12	s	s	NN
cord-006229-7yoilsho	1096	13	=	=	SYM
cord-006229-7yoilsho	1096	14	0.26	0.26	CD
cord-006229-7yoilsho	1096	15	;	;	:
cord-006229-7yoilsho	1096	16	p<0.001	p<0.001	CD
cord-006229-7yoilsho	1096	17	)	)	-RRB-
cord-006229-7yoilsho	1096	18	.	.	.
cord-006229-7yoilsho	1097	1	In	in	IN
cord-006229-7yoilsho	1097	2	a	a	DT
cord-006229-7yoilsho	1097	3	multivariable	multivariable	JJ
cord-006229-7yoilsho	1097	4	model	model	NN
cord-006229-7yoilsho	1097	5	including	include	VBG
cord-006229-7yoilsho	1097	6	all	all	DT
cord-006229-7yoilsho	1097	7	three	three	CD
cord-006229-7yoilsho	1097	8	parameters	parameter	NNS
cord-006229-7yoilsho	1097	9	,	,	,
cord-006229-7yoilsho	1097	10	only	only	RB
cord-006229-7yoilsho	1097	11	IPC	IPC	NNP
cord-006229-7yoilsho	1097	12	remained	remain	VBD
cord-006229-7yoilsho	1097	13	as	as	IN
cord-006229-7yoilsho	1097	14	significant	significant	JJ
cord-006229-7yoilsho	1097	15	predictor	predictor	NN
cord-006229-7yoilsho	1097	16	of	of	IN
cord-006229-7yoilsho	1097	17	platelet	platelet	NN
cord-006229-7yoilsho	1097	18	reactivity	reactivity	NN
cord-006229-7yoilsho	1097	19	(	(	-LRB-
cord-006229-7yoilsho	1097	20	p<0.001	p<0.001	CD
cord-006229-7yoilsho	1097	21	)	)	-RRB-
cord-006229-7yoilsho	1097	22	.	.	.
cord-006229-7yoilsho	1098	1	After	after	IN
cord-006229-7yoilsho	1098	2	adjustment	adjustment	NN
cord-006229-7yoilsho	1098	3	to	to	IN
cord-006229-7yoilsho	1098	4	known	know	VBN
cord-006229-7yoilsho	1098	5	predictors	predictor	NNS
cord-006229-7yoilsho	1098	6	of	of	IN
cord-006229-7yoilsho	1098	7	on	on	IN
cord-006229-7yoilsho	1098	8	-	-	HYPH
cord-006229-7yoilsho	1098	9	clopidogrel	clopidogrel	NN
cord-006229-7yoilsho	1098	10	platelet	platelet	NN
cord-006229-7yoilsho	1098	11	reactivity	reactivity	NN
cord-006229-7yoilsho	1098	12	including	include	VBG
cord-006229-7yoilsho	1098	13	cytochrome	cytochrome	NN
cord-006229-7yoilsho	1098	14	P450	p450	JJ
cord-006229-7yoilsho	1098	15	2C19	2c19	CD
cord-006229-7yoilsho	1098	16	polymorphisms	polymorphism	NNS
cord-006229-7yoilsho	1098	17	(	(	-LRB-
cord-006229-7yoilsho	1098	18	*	*	NFP
cord-006229-7yoilsho	1098	19	2	2	CD
cord-006229-7yoilsho	1098	20	and	and	CC
cord-006229-7yoilsho	1098	21	*	*	NFP
cord-006229-7yoilsho	1098	22	17	17	CD
cord-006229-7yoilsho	1098	23	)	)	-RRB-
cord-006229-7yoilsho	1098	24	,	,	,
cord-006229-7yoilsho	1098	25	age	age	NN
cord-006229-7yoilsho	1098	26	,	,	,
cord-006229-7yoilsho	1098	27	body	body	NN
cord-006229-7yoilsho	1098	28	mass	mass	NN
cord-006229-7yoilsho	1098	29	index	index	NN
cord-006229-7yoilsho	1098	30	,	,	,
cord-006229-7yoilsho	1098	31	diabetes	diabetes	NN
cord-006229-7yoilsho	1098	32	,	,	,
cord-006229-7yoilsho	1098	33	smoking	smoking	NN
cord-006229-7yoilsho	1098	34	and	and	CC
cord-006229-7yoilsho	1098	35	intrinsic	intrinsic	JJ
cord-006229-7yoilsho	1098	36	platelet	platelet	NN
cord-006229-7yoilsho	1098	37	reactivity	reactivity	NN
cord-006229-7yoilsho	1098	38	,	,	,
cord-006229-7yoilsho	1098	39	IPC	IPC	NNP
cord-006229-7yoilsho	1098	40	S21	S21	NNP
cord-006229-7yoilsho	1098	41	was	be	VBD
cord-006229-7yoilsho	1098	42	the	the	DT
cord-006229-7yoilsho	1098	43	strongest	strong	JJS
cord-006229-7yoilsho	1098	44	predictor	predictor	NN
cord-006229-7yoilsho	1098	45	of	of	IN
cord-006229-7yoilsho	1098	46	on	on	IN
cord-006229-7yoilsho	1098	47	-	-	HYPH
cord-006229-7yoilsho	1098	48	treatment	treatment	NN
cord-006229-7yoilsho	1098	49	platelet	platelet	NN
cord-006229-7yoilsho	1098	50	reactivity	reactivity	NN
cord-006229-7yoilsho	1098	51	(	(	-LRB-
cord-006229-7yoilsho	1098	52	partial	partial	JJ
cord-006229-7yoilsho	1098	53	η	η	NN
cord-006229-7yoilsho	1098	54	2	2	CD
cord-006229-7yoilsho	1098	55	=	=	SYM
cord-006229-7yoilsho	1098	56	0.045	0.045	CD
cord-006229-7yoilsho	1098	57	;	;	:
cord-006229-7yoilsho	1098	58	p<0.001	p<0.001	LS
cord-006229-7yoilsho	1098	59	)	)	-RRB-
cord-006229-7yoilsho	1098	60	followed	follow	VBN
cord-006229-7yoilsho	1098	61	by	by	IN
cord-006229-7yoilsho	1098	62	intrinsic	intrinsic	JJ
cord-006229-7yoilsho	1098	63	platelet	platelet	NN
cord-006229-7yoilsho	1098	64	reactivity	reactivity	NN
cord-006229-7yoilsho	1098	65	(	(	-LRB-
cord-006229-7yoilsho	1098	66	partial	partial	JJ
cord-006229-7yoilsho	1098	67	η	η	NN
cord-006229-7yoilsho	1098	68	2	2	CD
cord-006229-7yoilsho	1098	69	=	=	SYM
cord-006229-7yoilsho	1098	70	0.034	0.034	CD
cord-006229-7yoilsho	1098	71	;	;	:
cord-006229-7yoilsho	1098	72	p	p	NN
cord-006229-7yoilsho	1098	73	<	<	XX
cord-006229-7yoilsho	1098	74	0.002	0.002	CD
cord-006229-7yoilsho	1098	75	)	)	-RRB-
cord-006229-7yoilsho	1098	76	.	.	.
cord-006229-7yoilsho	1099	1	These	these	DT
cord-006229-7yoilsho	1099	2	findings	finding	NNS
cord-006229-7yoilsho	1099	3	prevailed	prevail	VBD
cord-006229-7yoilsho	1099	4	when	when	WRB
cord-006229-7yoilsho	1099	5	analyzing	analyze	VBG
cord-006229-7yoilsho	1099	6	subgroups	subgroup	NNS
cord-006229-7yoilsho	1099	7	of	of	IN
cord-006229-7yoilsho	1099	8	patients	patient	NNS
cord-006229-7yoilsho	1099	9	on	on	IN
cord-006229-7yoilsho	1099	10	clopidogrel	clopidogrel	NN
cord-006229-7yoilsho	1099	11	or	or	CC
cord-006229-7yoilsho	1099	12	on	on	IN
cord-006229-7yoilsho	1099	13	prasugrel	prasugrel	NNP
cord-006229-7yoilsho	1099	14	.	.	.
cord-006229-7yoilsho	1100	1	Conclusion	conclusion	NN
cord-006229-7yoilsho	1100	2	:	:	:
cord-006229-7yoilsho	1101	1	Immature	immature	JJ
cord-006229-7yoilsho	1101	2	platelet	platelet	NN
cord-006229-7yoilsho	1101	3	count	count	NN
cord-006229-7yoilsho	1101	4	is	be	VBZ
cord-006229-7yoilsho	1101	5	the	the	DT
cord-006229-7yoilsho	1101	6	strongest	strong	JJS
cord-006229-7yoilsho	1101	7	platelet	platelet	NN
cord-006229-7yoilsho	1101	8	count	count	NN
cord-006229-7yoilsho	1101	9	derived	derive	VBD
cord-006229-7yoilsho	1101	10	predictor	predictor	NN
cord-006229-7yoilsho	1101	11	of	of	IN
cord-006229-7yoilsho	1101	12	antiplatelet	antiplatelet	JJ
cord-006229-7yoilsho	1101	13	response	response	NN
cord-006229-7yoilsho	1101	14	to	to	IN
cord-006229-7yoilsho	1101	15	thienopyridine	thienopyridine	JJ
cord-006229-7yoilsho	1101	16	treatment	treatment	NN
cord-006229-7yoilsho	1101	17	.	.	.
cord-006229-7yoilsho	1102	1	Given	give	VBN
cord-006229-7yoilsho	1102	2	its	-PRON-	PRP$
cord-006229-7yoilsho	1102	3	easy	easy	JJ
cord-006229-7yoilsho	1102	4	availability	availability	NN
cord-006229-7yoilsho	1102	5	together	together	RB
cord-006229-7yoilsho	1102	6	with	with	IN
cord-006229-7yoilsho	1102	7	its	-PRON-	PRP$
cord-006229-7yoilsho	1102	8	even	even	RB
cord-006229-7yoilsho	1102	9	stronger	strong	JJR
cord-006229-7yoilsho	1102	10	association	association	NN
cord-006229-7yoilsho	1102	11	with	with	IN
cord-006229-7yoilsho	1102	12	on	on	IN
cord-006229-7yoilsho	1102	13	-	-	HYPH
cord-006229-7yoilsho	1102	14	treatment	treatment	NN
cord-006229-7yoilsho	1102	15	platelet	platelet	NN
cord-006229-7yoilsho	1102	16	reactivity	reactivity	NN
cord-006229-7yoilsho	1102	17	when	when	WRB
cord-006229-7yoilsho	1102	18	compared	compare	VBN
cord-006229-7yoilsho	1102	19	to	to	IN
cord-006229-7yoilsho	1102	20	known	know	VBN
cord-006229-7yoilsho	1102	21	predictors	predictor	NNS
cord-006229-7yoilsho	1102	22	including	include	VBG
cord-006229-7yoilsho	1102	23	the	the	DT
cord-006229-7yoilsho	1102	24	CYP	CYP	NNP
cord-006229-7yoilsho	1102	25	2C19	2c19	CD
cord-006229-7yoilsho	1103	1	*	*	NFP
cord-006229-7yoilsho	1103	2	2	2	CD
cord-006229-7yoilsho	1103	3	polymorphism	polymorphism	NN
cord-006229-7yoilsho	1103	4	,	,	,
cord-006229-7yoilsho	1103	5	immature	immature	JJ
cord-006229-7yoilsho	1103	6	platelet	platelet	NN
cord-006229-7yoilsho	1103	7	count	count	NN
cord-006229-7yoilsho	1103	8	might	may	MD
cord-006229-7yoilsho	1103	9	become	become	VB
cord-006229-7yoilsho	1103	10	the	the	DT
cord-006229-7yoilsho	1103	11	preferable	preferable	JJ
cord-006229-7yoilsho	1103	12	predictor	predictor	NN
cord-006229-7yoilsho	1103	13	of	of	IN
cord-006229-7yoilsho	1103	14	antiplatelet	antiplatelet	JJ
cord-006229-7yoilsho	1103	15	response	response	NN
cord-006229-7yoilsho	1103	16	to	to	IN
cord-006229-7yoilsho	1103	17	thienopyridine	thienopyridine	JJ
cord-006229-7yoilsho	1103	18	treatment	treatment	NN
cord-006229-7yoilsho	1103	19	.	.	.
cord-006229-7yoilsho	1104	1	Cutaneous	cutaneous	JJ
cord-006229-7yoilsho	1104	2	squamous	squamous	JJ
cord-006229-7yoilsho	1104	3	cell	cell	NN
cord-006229-7yoilsho	1104	4	carcinoma	carcinoma	NN
cord-006229-7yoilsho	1104	5	(	(	-LRB-
cord-006229-7yoilsho	1104	6	cSCC	cSCC	NNP
cord-006229-7yoilsho	1104	7	)	)	-RRB-
cord-006229-7yoilsho	1104	8	is	be	VBZ
cord-006229-7yoilsho	1104	9	the	the	DT
cord-006229-7yoilsho	1104	10	second	second	JJ
cord-006229-7yoilsho	1104	11	most	most	RBS
cord-006229-7yoilsho	1104	12	common	common	JJ
cord-006229-7yoilsho	1104	13	human	human	JJ
cord-006229-7yoilsho	1104	14	cancer	cancer	NN
cord-006229-7yoilsho	1104	15	with	with	IN
cord-006229-7yoilsho	1104	16	continuously	continuously	RB
cord-006229-7yoilsho	1104	17	rising	rise	VBG
cord-006229-7yoilsho	1104	18	incidences	incidence	NNS
cord-006229-7yoilsho	1104	19	worldwide	worldwide	RB
cord-006229-7yoilsho	1104	20	.	.	.
cord-006229-7yoilsho	1105	1	Primarily	primarily	RB
cord-006229-7yoilsho	1105	2	caused	cause	VBN
cord-006229-7yoilsho	1105	3	by	by	IN
cord-006229-7yoilsho	1105	4	cumulative	cumulative	JJ
cord-006229-7yoilsho	1105	5	UVB	uvb	NN
cord-006229-7yoilsho	1105	6	exposure	exposure	NN
cord-006229-7yoilsho	1105	7	,	,	,
cord-006229-7yoilsho	1105	8	cSCC	cscc	NN
cord-006229-7yoilsho	1105	9	accounts	account	NNS
cord-006229-7yoilsho	1105	10	for	for	IN
cord-006229-7yoilsho	1105	11	considerable	considerable	JJ
cord-006229-7yoilsho	1105	12	costs	cost	NNS
cord-006229-7yoilsho	1105	13	for	for	IN
cord-006229-7yoilsho	1105	14	health	health	NN
cord-006229-7yoilsho	1105	15	care	care	NN
cord-006229-7yoilsho	1105	16	systems	system	NNS
cord-006229-7yoilsho	1105	17	and	and	CC
cord-006229-7yoilsho	1105	18	poses	pose	VBZ
cord-006229-7yoilsho	1105	19	a	a	DT
cord-006229-7yoilsho	1105	20	deadly	deadly	JJ
cord-006229-7yoilsho	1105	21	risk	risk	NN
cord-006229-7yoilsho	1105	22	especially	especially	RB
cord-006229-7yoilsho	1105	23	to	to	IN
cord-006229-7yoilsho	1105	24	organ	organ	NN
cord-006229-7yoilsho	1105	25	transplant	transplant	NN
cord-006229-7yoilsho	1105	26	recipients	recipient	NNS
cord-006229-7yoilsho	1105	27	[	[	-LRB-
cord-006229-7yoilsho	1105	28	1	1	CD
cord-006229-7yoilsho	1105	29	]	]	-RRB-
cord-006229-7yoilsho	1105	30	.	.	.
cord-006229-7yoilsho	1106	1	Current	current	JJ
cord-006229-7yoilsho	1106	2	chemotherapy	chemotherapy	NN
cord-006229-7yoilsho	1106	3	needs	need	VBZ
cord-006229-7yoilsho	1106	4	to	to	TO
cord-006229-7yoilsho	1106	5	be	be	VB
cord-006229-7yoilsho	1106	6	improved	improve	VBN
cord-006229-7yoilsho	1106	7	,	,	,
cord-006229-7yoilsho	1106	8	because	because	IN
cord-006229-7yoilsho	1106	9	even	even	RB
cord-006229-7yoilsho	1106	10	the	the	DT
cord-006229-7yoilsho	1106	11	topical	topical	JJ
cord-006229-7yoilsho	1106	12	treatment	treatment	NN
cord-006229-7yoilsho	1106	13	for	for	IN
cord-006229-7yoilsho	1106	14	cSCC	cSCC	NNP
cord-006229-7yoilsho	1106	15	's	's	POS
cord-006229-7yoilsho	1106	16	carcinoma	carcinoma	NN
cord-006229-7yoilsho	1106	17	in	in	IN
cord-006229-7yoilsho	1106	18	situ	situ	NN
cord-006229-7yoilsho	1106	19	bears	bear	NNS
cord-006229-7yoilsho	1106	20	limited	limited	JJ
cord-006229-7yoilsho	1106	21	efficacy	efficacy	NN
cord-006229-7yoilsho	1106	22	and	and	CC
cord-006229-7yoilsho	1106	23	painful	painful	JJ
cord-006229-7yoilsho	1106	24	adverse	adverse	JJ
cord-006229-7yoilsho	1106	25	effects	effect	NNS
cord-006229-7yoilsho	1106	26	[	[	-LRB-
cord-006229-7yoilsho	1106	27	2	2	CD
cord-006229-7yoilsho	1106	28	]	]	-RRB-
cord-006229-7yoilsho	1106	29	.	.	.
cord-006229-7yoilsho	1107	1	However	however	RB
cord-006229-7yoilsho	1107	2	,	,	,
cord-006229-7yoilsho	1107	3	animal	animal	NN
cord-006229-7yoilsho	1107	4	-	-	HYPH
cord-006229-7yoilsho	1107	5	based	base	VBN
cord-006229-7yoilsho	1107	6	approaches	approach	NNS
cord-006229-7yoilsho	1107	7	in	in	IN
cord-006229-7yoilsho	1107	8	preclinical	preclinical	JJ
cord-006229-7yoilsho	1107	9	development	development	NN
cord-006229-7yoilsho	1107	10	contribute	contribute	VBP
cord-006229-7yoilsho	1107	11	to	to	IN
cord-006229-7yoilsho	1107	12	the	the	DT
cord-006229-7yoilsho	1107	13	frequent	frequent	JJ
cord-006229-7yoilsho	1107	14	failure	failure	NN
cord-006229-7yoilsho	1107	15	of	of	IN
cord-006229-7yoilsho	1107	16	investigational	investigational	JJ
cord-006229-7yoilsho	1107	17	new	new	JJ
cord-006229-7yoilsho	1107	18	drugs	drug	NNS
cord-006229-7yoilsho	1107	19	in	in	IN
cord-006229-7yoilsho	1107	20	clinical	clinical	JJ
cord-006229-7yoilsho	1107	21	trials	trial	NNS
cord-006229-7yoilsho	1107	22	[	[	-LRB-
cord-006229-7yoilsho	1107	23	3	3	CD
cord-006229-7yoilsho	1107	24	]	]	-RRB-
cord-006229-7yoilsho	1107	25	.	.	.
cord-006229-7yoilsho	1108	1	Herein	herein	RB
cord-006229-7yoilsho	1108	2	,	,	,
cord-006229-7yoilsho	1108	3	we	-PRON-	PRP
cord-006229-7yoilsho	1108	4	characterized	characterize	VBD
cord-006229-7yoilsho	1108	5	a	a	DT
cord-006229-7yoilsho	1108	6	human	human	JJ
cord-006229-7yoilsho	1108	7	cell	cell	NN
cord-006229-7yoilsho	1108	8	-	-	HYPH
cord-006229-7yoilsho	1108	9	based	base	VBN
cord-006229-7yoilsho	1108	10	cSCC	cscc	NN
cord-006229-7yoilsho	1108	11	model	model	NN
cord-006229-7yoilsho	1108	12	,	,	,
cord-006229-7yoilsho	1108	13	normal	normal	JJ
cord-006229-7yoilsho	1108	14	reconstructed	reconstruct	VBN
cord-006229-7yoilsho	1108	15	human	human	JJ
cord-006229-7yoilsho	1108	16	skin	skin	NN
cord-006229-7yoilsho	1108	17	(	(	-LRB-
cord-006229-7yoilsho	1108	18	RHS	RHS	NNP
cord-006229-7yoilsho	1108	19	)	)	-RRB-
cord-006229-7yoilsho	1108	20	served	serve	VBD
cord-006229-7yoilsho	1108	21	as	as	IN
cord-006229-7yoilsho	1108	22	control	control	NN
cord-006229-7yoilsho	1108	23	.	.	.
cord-006229-7yoilsho	1109	1	Whereas	whereas	IN
cord-006229-7yoilsho	1109	2	RHS	RHS	NNP
cord-006229-7yoilsho	1109	3	exhibited	exhibit	VBD
cord-006229-7yoilsho	1109	4	low	low	JJ
cord-006229-7yoilsho	1109	5	proliferation	proliferation	NN
cord-006229-7yoilsho	1109	6	,	,	,
cord-006229-7yoilsho	1109	7	the	the	DT
cord-006229-7yoilsho	1109	8	co	co	NN
cord-006229-7yoilsho	1109	9	-	-	NN
cord-006229-7yoilsho	1109	10	culture	culture	NN
cord-006229-7yoilsho	1109	11	with	with	IN
cord-006229-7yoilsho	1109	12	cSCC	cscc	NN
cord-006229-7yoilsho	1109	13	increased	increase	VBN
cord-006229-7yoilsho	1109	14	Ki-67	Ki-67	NNP
cord-006229-7yoilsho	1109	15	index	index	NN
cord-006229-7yoilsho	1109	16	23-fold	23-fold	CD
cord-006229-7yoilsho	1109	17	in	in	IN
cord-006229-7yoilsho	1109	18	the	the	DT
cord-006229-7yoilsho	1109	19	cSCC	cscc	NN
cord-006229-7yoilsho	1109	20	model	model	NN
cord-006229-7yoilsho	1109	21	(	(	-LRB-
cord-006229-7yoilsho	1109	22	p£0.001	p£0.001	NNP
cord-006229-7yoilsho	1109	23	)	)	-RRB-
cord-006229-7yoilsho	1109	24	.	.	.
cord-006229-7yoilsho	1110	1	While	while	IN
cord-006229-7yoilsho	1110	2	the	the	DT
cord-006229-7yoilsho	1110	3	presence	presence	NN
cord-006229-7yoilsho	1110	4	of	of	IN
cord-006229-7yoilsho	1110	5	claudin-4	claudin-4	NNP
cord-006229-7yoilsho	1110	6	and	and	CC
cord-006229-7yoilsho	1110	7	occludin	occludin	NNP
cord-006229-7yoilsho	1110	8	were	be	VBD
cord-006229-7yoilsho	1110	9	distinctly	distinctly	RB
cord-006229-7yoilsho	1110	10	reduced	reduce	VBN
cord-006229-7yoilsho	1110	11	,	,	,
cord-006229-7yoilsho	1110	12	zonula	zonula	NNP
cord-006229-7yoilsho	1110	13	occludens	occludens	NNP
cord-006229-7yoilsho	1110	14	protein-1	protein-1	NNP
cord-006229-7yoilsho	1110	15	was	be	VBD
cord-006229-7yoilsho	1110	16	more	more	RBR
cord-006229-7yoilsho	1110	17	wide	wide	JJ
cord-006229-7yoilsho	1110	18	-	-	HYPH
cord-006229-7yoilsho	1110	19	spread	spread	NN
cord-006229-7yoilsho	1110	20	,	,	,
cord-006229-7yoilsho	1110	21	and	and	CC
cord-006229-7yoilsho	1110	22	claudin-1	claudin-1	NNP
cord-006229-7yoilsho	1110	23	was	be	VBD
cord-006229-7yoilsho	1110	24	heterogeneously	heterogeneously	RB
cord-006229-7yoilsho	1110	25	distributed	distribute	VBN
cord-006229-7yoilsho	1110	26	within	within	IN
cord-006229-7yoilsho	1110	27	the	the	DT
cord-006229-7yoilsho	1110	28	cSCC	cscc	NN
cord-006229-7yoilsho	1110	29	model	model	NN
cord-006229-7yoilsho	1110	30	compared	compare	VBN
cord-006229-7yoilsho	1110	31	with	with	IN
cord-006229-7yoilsho	1110	32	RHS	RHS	NNP
cord-006229-7yoilsho	1110	33	.	.	.
cord-006229-7yoilsho	1111	1	This	this	DT
cord-006229-7yoilsho	1111	2	is	be	VBZ
cord-006229-7yoilsho	1111	3	in	in	IN
cord-006229-7yoilsho	1111	4	accordance	accordance	NN
cord-006229-7yoilsho	1111	5	to	to	IN
cord-006229-7yoilsho	1111	6	the	the	DT
cord-006229-7yoilsho	1111	7	in	in	IN
cord-006229-7yoilsho	1111	8	vivo	vivo	NN
cord-006229-7yoilsho	1111	9	situation	situation	NN
cord-006229-7yoilsho	1111	10	[	[	-LRB-
cord-006229-7yoilsho	1111	11	4	4	CD
cord-006229-7yoilsho	1111	12	]	]	-RRB-
cord-006229-7yoilsho	1111	13	and	and	CC
cord-006229-7yoilsho	1111	14	likely	likely	RB
cord-006229-7yoilsho	1111	15	contributes	contribute	VBZ
cord-006229-7yoilsho	1111	16	to	to	IN
cord-006229-7yoilsho	1111	17	the	the	DT
cord-006229-7yoilsho	1111	18	impaired	impair	VBN
cord-006229-7yoilsho	1111	19	barrier	barrier	NN
cord-006229-7yoilsho	1111	20	function	function	NN
cord-006229-7yoilsho	1111	21	of	of	IN
cord-006229-7yoilsho	1111	22	the	the	DT
cord-006229-7yoilsho	1111	23	cSCC	cscc	NN
cord-006229-7yoilsho	1111	24	model	model	NN
cord-006229-7yoilsho	1111	25	,	,	,
cord-006229-7yoilsho	1111	26	as	as	IN
cord-006229-7yoilsho	1111	27	demonstrated	demonstrate	VBN
cord-006229-7yoilsho	1111	28	for	for	IN
cord-006229-7yoilsho	1111	29	2.6-fold	2.6-fold	CD
cord-006229-7yoilsho	1111	30	increased	increase	VBN
cord-006229-7yoilsho	1111	31	caffeine	caffeine	NN
cord-006229-7yoilsho	1111	32	permeation	permeation	NN
cord-006229-7yoilsho	1111	33	.	.	.
cord-006229-7yoilsho	1112	1	Finally	finally	RB
cord-006229-7yoilsho	1112	2	,	,	,
cord-006229-7yoilsho	1112	3	the	the	DT
cord-006229-7yoilsho	1112	4	ingenol	ingenol	JJ
cord-006229-7yoilsho	1112	5	mebutate	mebutate	NNP
cord-006229-7yoilsho	1112	6	effects	effect	NNS
cord-006229-7yoilsho	1112	7	in	in	IN
cord-006229-7yoilsho	1112	8	the	the	DT
cord-006229-7yoilsho	1112	9	cSCC	cscc	NN
cord-006229-7yoilsho	1112	10	model	model	NN
cord-006229-7yoilsho	1112	11	and	and	CC
cord-006229-7yoilsho	1112	12	RHS	RHS	NNP
cord-006229-7yoilsho	1112	13	closely	closely	RB
cord-006229-7yoilsho	1112	14	mimic	mimic	VBP
cord-006229-7yoilsho	1112	15	the	the	DT
cord-006229-7yoilsho	1112	16	anti	anti	JJ
cord-006229-7yoilsho	1112	17	-	-	JJ
cord-006229-7yoilsho	1112	18	tumor	tumor	JJ
cord-006229-7yoilsho	1112	19	effect	effect	NN
cord-006229-7yoilsho	1112	20	and	and	CC
cord-006229-7yoilsho	1112	21	the	the	DT
cord-006229-7yoilsho	1112	22	adverse	adverse	JJ
cord-006229-7yoilsho	1112	23	reactions	reaction	NNS
cord-006229-7yoilsho	1112	24	in	in	IN
cord-006229-7yoilsho	1112	25	patients	patient	NNS
cord-006229-7yoilsho	1112	26	[	[	-LRB-
cord-006229-7yoilsho	1112	27	2	2	CD
cord-006229-7yoilsho	1112	28	]	]	-RRB-
cord-006229-7yoilsho	1112	29	,	,	,
cord-006229-7yoilsho	1112	30	both	both	DT
cord-006229-7yoilsho	1112	31	linked	link	VBD
cord-006229-7yoilsho	1112	32	to	to	IN
cord-006229-7yoilsho	1112	33	the	the	DT
cord-006229-7yoilsho	1112	34	drug	drug	NN
cord-006229-7yoilsho	1112	35	's	's	POS
cord-006229-7yoilsho	1112	36	inherent	inherent	JJ
cord-006229-7yoilsho	1112	37	cytotoxicity	cytotoxicity	NN
cord-006229-7yoilsho	1112	38	.	.	.
cord-006229-7yoilsho	1113	1	In	in	IN
cord-006229-7yoilsho	1113	2	conclusion	conclusion	NN
cord-006229-7yoilsho	1113	3	,	,	,
cord-006229-7yoilsho	1113	4	the	the	DT
cord-006229-7yoilsho	1113	5	thoroughly	thoroughly	RB
cord-006229-7yoilsho	1113	6	characterization	characterization	NN
cord-006229-7yoilsho	1113	7	of	of	IN
cord-006229-7yoilsho	1113	8	disease	disease	NN
cord-006229-7yoilsho	1113	9	models	model	NNS
cord-006229-7yoilsho	1113	10	fosters	foster	VBZ
cord-006229-7yoilsho	1113	11	both	both	CC
cord-006229-7yoilsho	1113	12	advanced	advanced	JJ
cord-006229-7yoilsho	1113	13	preclinical	preclinical	JJ
cord-006229-7yoilsho	1113	14	drug	drug	NN
cord-006229-7yoilsho	1113	15	development	development	NN
cord-006229-7yoilsho	1113	16	and	and	CC
cord-006229-7yoilsho	1113	17	improved	improve	VBN
cord-006229-7yoilsho	1113	18	cSCC	cscc	NN
cord-006229-7yoilsho	1113	19	treatment	treatment	NN
cord-006229-7yoilsho	1113	20	.	.	.
cord-006229-7yoilsho	1114	1	Funded	fund	VBN
cord-006229-7yoilsho	1114	2	by	by	IN
cord-006229-7yoilsho	1114	3	the	the	DT
cord-006229-7yoilsho	1114	4	German	german	JJ
cord-006229-7yoilsho	1114	5	government	government	NN
cord-006229-7yoilsho	1114	6	,	,	,
cord-006229-7yoilsho	1114	7	the	the	DT
cord-006229-7yoilsho	1114	8	Berlin	Berlin	NNP
cord-006229-7yoilsho	1114	9	-	-	HYPH
cord-006229-7yoilsho	1114	10	Brandenburg	Brandenburg	NNP
cord-006229-7yoilsho	1114	11	Research	Research	NNP
cord-006229-7yoilsho	1114	12	Platform	Platform	NNP
cord-006229-7yoilsho	1114	13	BB3R	BB3R	NNS
cord-006229-7yoilsho	1114	14	with	with	IN
cord-006229-7yoilsho	1114	15	integrated	integrated	JJ
cord-006229-7yoilsho	1114	16	graduate	graduate	NN
cord-006229-7yoilsho	1114	17	education	education	NN
cord-006229-7yoilsho	1114	18	was	be	VBD
cord-006229-7yoilsho	1114	19	launched	launch	VBN
cord-006229-7yoilsho	1114	20	in	in	IN
cord-006229-7yoilsho	1114	21	2014	2014	CD
cord-006229-7yoilsho	1114	22	.	.	.
cord-006229-7yoilsho	1115	1	The	the	DT
cord-006229-7yoilsho	1115	2	aim	aim	NN
cord-006229-7yoilsho	1115	3	of	of	IN
cord-006229-7yoilsho	1115	4	this	this	DT
cord-006229-7yoilsho	1115	5	research	research	NN
cord-006229-7yoilsho	1115	6	platform	platform	NN
cord-006229-7yoilsho	1115	7	,	,	,
cord-006229-7yoilsho	1115	8	along	along	IN
cord-006229-7yoilsho	1115	9	with	with	IN
cord-006229-7yoilsho	1115	10	the	the	DT
cord-006229-7yoilsho	1115	11	associated	associated	JJ
cord-006229-7yoilsho	1115	12	graduate	graduate	NN
cord-006229-7yoilsho	1115	13	school	school	NN
cord-006229-7yoilsho	1115	14	,	,	,
cord-006229-7yoilsho	1115	15	is	be	VBZ
cord-006229-7yoilsho	1115	16	to	to	TO
cord-006229-7yoilsho	1115	17	close	close	VB
cord-006229-7yoilsho	1115	18	substantial	substantial	JJ
cord-006229-7yoilsho	1115	19	knowledge	knowledge	NN
cord-006229-7yoilsho	1115	20	gaps	gap	NNS
cord-006229-7yoilsho	1115	21	in	in	IN
cord-006229-7yoilsho	1115	22	the	the	DT
cord-006229-7yoilsho	1115	23	fields	field	NNS
cord-006229-7yoilsho	1115	24	of	of	IN
cord-006229-7yoilsho	1115	25	the	the	DT
cord-006229-7yoilsho	1115	26	3Rs	3rs	NN
cord-006229-7yoilsho	1115	27	and	and	CC
cord-006229-7yoilsho	1115	28	to	to	TO
cord-006229-7yoilsho	1115	29	find	find	VB
cord-006229-7yoilsho	1115	30	alternatives	alternative	NNS
cord-006229-7yoilsho	1115	31	to	to	IN
cord-006229-7yoilsho	1115	32	animal	animal	NN
cord-006229-7yoilsho	1115	33	experimentation	experimentation	NN
cord-006229-7yoilsho	1115	34	within	within	IN
cord-006229-7yoilsho	1115	35	the	the	DT
cord-006229-7yoilsho	1115	36	next	next	JJ
cord-006229-7yoilsho	1115	37	years	year	NNS
cord-006229-7yoilsho	1115	38	.	.	.
cord-006229-7yoilsho	1116	1	A	a	DT
cord-006229-7yoilsho	1116	2	panel	panel	NN
cord-006229-7yoilsho	1116	3	of	of	IN
cord-006229-7yoilsho	1116	4	3R	3R	NNP
cord-006229-7yoilsho	1116	5	experts	expert	NNS
cord-006229-7yoilsho	1116	6	has	have	VBZ
cord-006229-7yoilsho	1116	7	been	be	VBN
cord-006229-7yoilsho	1116	8	set	set	VBN
cord-006229-7yoilsho	1116	9	up	up	RP
cord-006229-7yoilsho	1116	10	to	to	TO
cord-006229-7yoilsho	1116	11	provide	provide	VB
cord-006229-7yoilsho	1116	12	advice	advice	NN
cord-006229-7yoilsho	1116	13	and	and	CC
cord-006229-7yoilsho	1116	14	assistance	assistance	NN
cord-006229-7yoilsho	1116	15	and	and	CC
cord-006229-7yoilsho	1116	16	to	to	TO
cord-006229-7yoilsho	1116	17	raise	raise	VB
cord-006229-7yoilsho	1116	18	awareness	awareness	NN
cord-006229-7yoilsho	1116	19	in	in	IN
cord-006229-7yoilsho	1116	20	society	society	NN
cord-006229-7yoilsho	1116	21	for	for	IN
cord-006229-7yoilsho	1116	22	3R	3r	NN
cord-006229-7yoilsho	1116	23	-	-	HYPH
cord-006229-7yoilsho	1116	24	related	relate	VBN
cord-006229-7yoilsho	1116	25	issues	issue	NNS
cord-006229-7yoilsho	1116	26	.	.	.
cord-006229-7yoilsho	1117	1	Research	research	NN
cord-006229-7yoilsho	1117	2	in	in	IN
cord-006229-7yoilsho	1117	3	BB3R	BB3R	NNP
cord-006229-7yoilsho	1117	4	investigates	investigate	VBZ
cord-006229-7yoilsho	1117	5	physiological	physiological	JJ
cord-006229-7yoilsho	1117	6	functions	function	NNS
cord-006229-7yoilsho	1117	7	on	on	IN
cord-006229-7yoilsho	1117	8	different	different	JJ
cord-006229-7yoilsho	1117	9	levels	level	NNS
cord-006229-7yoilsho	1117	10	to	to	TO
cord-006229-7yoilsho	1117	11	establish	establish	VB
cord-006229-7yoilsho	1117	12	alternative	alternative	JJ
cord-006229-7yoilsho	1117	13	methods	method	NNS
cord-006229-7yoilsho	1117	14	for	for	IN
cord-006229-7yoilsho	1117	15	preclinical	preclinical	JJ
cord-006229-7yoilsho	1117	16	drug	drug	NN
cord-006229-7yoilsho	1117	17	development	development	NN
cord-006229-7yoilsho	1117	18	and	and	CC
cord-006229-7yoilsho	1117	19	basic	basic	JJ
cord-006229-7yoilsho	1117	20	research	research	NN
cord-006229-7yoilsho	1117	21	.	.	.
cord-006229-7yoilsho	1118	1	The	the	DT
cord-006229-7yoilsho	1118	2	principal	principal	JJ
cord-006229-7yoilsho	1118	3	investigators	investigator	NNS
cord-006229-7yoilsho	1118	4	aim	aim	VBP
cord-006229-7yoilsho	1118	5	at	at	IN
cord-006229-7yoilsho	1118	6	facilitating	facilitate	VBG
cord-006229-7yoilsho	1118	7	research	research	NN
cord-006229-7yoilsho	1118	8	collaborations	collaboration	NNS
cord-006229-7yoilsho	1118	9	and	and	CC
cord-006229-7yoilsho	1118	10	sustainable	sustainable	JJ
cord-006229-7yoilsho	1118	11	research	research	NN
cord-006229-7yoilsho	1118	12	activities	activity	NNS
cord-006229-7yoilsho	1118	13	in	in	IN
cord-006229-7yoilsho	1118	14	the	the	DT
cord-006229-7yoilsho	1118	15	region	region	NN
cord-006229-7yoilsho	1118	16	Berlin	Berlin	NNP
cord-006229-7yoilsho	1118	17	-	-	HYPH
cord-006229-7yoilsho	1118	18	Brandenburg	Brandenburg	NNP
cord-006229-7yoilsho	1118	19	and	and	CC
cord-006229-7yoilsho	1118	20	abroad	abroad	RB
cord-006229-7yoilsho	1118	21	.	.	.
cord-006229-7yoilsho	1119	1	An	an	DT
cord-006229-7yoilsho	1119	2	integrated	integrated	JJ
cord-006229-7yoilsho	1119	3	BB3R	BB3R	NNP
cord-006229-7yoilsho	1119	4	graduate	graduate	NN
cord-006229-7yoilsho	1119	5	program	program	NN
cord-006229-7yoilsho	1119	6	has	have	VBZ
cord-006229-7yoilsho	1119	7	been	be	VBN
cord-006229-7yoilsho	1119	8	developed	develop	VBN
cord-006229-7yoilsho	1119	9	to	to	TO
cord-006229-7yoilsho	1119	10	offer	offer	VB
cord-006229-7yoilsho	1119	11	structured	structured	JJ
cord-006229-7yoilsho	1119	12	training	training	NN
cord-006229-7yoilsho	1119	13	to	to	IN
cord-006229-7yoilsho	1119	14	graduate	graduate	VB
cord-006229-7yoilsho	1119	15	students	student	NNS
cord-006229-7yoilsho	1119	16	in	in	IN
cord-006229-7yoilsho	1119	17	a	a	DT
cord-006229-7yoilsho	1119	18	specific	specific	JJ
cord-006229-7yoilsho	1119	19	,	,	,
cord-006229-7yoilsho	1119	20	mandatory	mandatory	JJ
cord-006229-7yoilsho	1119	21	course	course	NN
cord-006229-7yoilsho	1119	22	program	program	NN
cord-006229-7yoilsho	1119	23	on	on	IN
cord-006229-7yoilsho	1119	24	3R	3R	NNP
cord-006229-7yoilsho	1119	25	including	include	VBG
cord-006229-7yoilsho	1119	26	modules	module	NNS
cord-006229-7yoilsho	1119	27	on	on	IN
cord-006229-7yoilsho	1119	28	ethics	ethic	NNS
cord-006229-7yoilsho	1119	29	and	and	CC
cord-006229-7yoilsho	1119	30	legislation	legislation	NN
cord-006229-7yoilsho	1119	31	.	.	.
cord-006229-7yoilsho	1120	1	Currently	currently	RB
cord-006229-7yoilsho	1120	2	,	,	,
cord-006229-7yoilsho	1120	3	14	14	CD
cord-006229-7yoilsho	1120	4	PhD	phd	NN
cord-006229-7yoilsho	1120	5	students	student	NNS
cord-006229-7yoilsho	1120	6	are	be	VBP
cord-006229-7yoilsho	1120	7	qualified	qualified	JJ
cord-006229-7yoilsho	1120	8	for	for	IN
cord-006229-7yoilsho	1120	9	management	management	NN
cord-006229-7yoilsho	1120	10	positions	position	NNS
cord-006229-7yoilsho	1120	11	in	in	IN
cord-006229-7yoilsho	1120	12	professional	professional	JJ
cord-006229-7yoilsho	1120	13	areas	area	NNS
cord-006229-7yoilsho	1120	14	related	relate	VBN
cord-006229-7yoilsho	1120	15	to	to	IN
cord-006229-7yoilsho	1120	16	the	the	DT
cord-006229-7yoilsho	1120	17	3Rs	3rs	NN
cord-006229-7yoilsho	1120	18	,	,	,
cord-006229-7yoilsho	1120	19	and	and	CC
cord-006229-7yoilsho	1120	20	three	three	CD
cord-006229-7yoilsho	1120	21	junior	junior	JJ
cord-006229-7yoilsho	1120	22	research	research	NN
cord-006229-7yoilsho	1120	23	groups	group	NNS
cord-006229-7yoilsho	1120	24	are	be	VBP
cord-006229-7yoilsho	1120	25	now	now	RB
cord-006229-7yoilsho	1120	26	ready	ready	JJ
cord-006229-7yoilsho	1120	27	to	to	TO
cord-006229-7yoilsho	1120	28	expand	expand	VB
cord-006229-7yoilsho	1120	29	their	-PRON-	PRP$
cord-006229-7yoilsho	1120	30	regional	regional	JJ
cord-006229-7yoilsho	1120	31	research	research	NN
cord-006229-7yoilsho	1120	32	activities	activity	NNS
cord-006229-7yoilsho	1120	33	nationwide	nationwide	RB
cord-006229-7yoilsho	1120	34	.	.	.
cord-006229-7yoilsho	1121	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	1121	2	,	,	,
cord-006229-7yoilsho	1121	3	the	the	DT
cord-006229-7yoilsho	1121	4	concept	concept	NN
cord-006229-7yoilsho	1121	5	of	of	IN
cord-006229-7yoilsho	1121	6	a	a	DT
cord-006229-7yoilsho	1121	7	novel	novel	JJ
cord-006229-7yoilsho	1121	8	lecture	lecture	NN
cord-006229-7yoilsho	1121	9	series	series	NN
cord-006229-7yoilsho	1121	10	for	for	IN
cord-006229-7yoilsho	1121	11	master	master	NN
cord-006229-7yoilsho	1121	12	students	student	NNS
cord-006229-7yoilsho	1121	13	and	and	CC
cord-006229-7yoilsho	1121	14	undergraduates	undergraduate	NNS
cord-006229-7yoilsho	1121	15	has	have	VBZ
cord-006229-7yoilsho	1121	16	been	be	VBN
cord-006229-7yoilsho	1121	17	designed	design	VBN
cord-006229-7yoilsho	1121	18	and	and	CC
cord-006229-7yoilsho	1121	19	awarded	award	VBN
cord-006229-7yoilsho	1121	20	the	the	DT
cord-006229-7yoilsho	1121	21	Animal	Animal	NNP
cord-006229-7yoilsho	1121	22	Welfare	Welfare	NNP
cord-006229-7yoilsho	1121	23	Research	Research	NNP
cord-006229-7yoilsho	1121	24	Award	Award	NNP
cord-006229-7yoilsho	1121	25	for	for	IN
cord-006229-7yoilsho	1121	26	Berlin	Berlin	NNP
cord-006229-7yoilsho	1121	27	-	-	HYPH
cord-006229-7yoilsho	1121	28	Brandenburg	Brandenburg	NNP
cord-006229-7yoilsho	1121	29	in	in	IN
cord-006229-7yoilsho	1121	30	teaching	teaching	NN
cord-006229-7yoilsho	1121	31	and	and	CC
cord-006229-7yoilsho	1121	32	education	education	NN
cord-006229-7yoilsho	1121	33	.	.	.
cord-006229-7yoilsho	1122	1	The	the	DT
cord-006229-7yoilsho	1122	2	state	state	NN
cord-006229-7yoilsho	1122	3	government	government	NN
cord-006229-7yoilsho	1122	4	of	of	IN
cord-006229-7yoilsho	1122	5	Berlin	Berlin	NNP
cord-006229-7yoilsho	1122	6	supports	support	VBZ
cord-006229-7yoilsho	1122	7	the	the	DT
cord-006229-7yoilsho	1122	8	research	research	NN
cord-006229-7yoilsho	1122	9	platform	platform	NN
cord-006229-7yoilsho	1122	10	BB3R	BB3R	NNS
cord-006229-7yoilsho	1122	11	and	and	CC
cord-006229-7yoilsho	1122	12	will	will	MD
cord-006229-7yoilsho	1122	13	be	be	VB
cord-006229-7yoilsho	1122	14	funding	fund	VBG
cord-006229-7yoilsho	1122	15	an	an	DT
cord-006229-7yoilsho	1122	16	additional	additional	JJ
cord-006229-7yoilsho	1122	17	professorship	professorship	NN
cord-006229-7yoilsho	1122	18	at	at	IN
cord-006229-7yoilsho	1122	19	the	the	DT
cord-006229-7yoilsho	1122	20	FU	FU	NNP
cord-006229-7yoilsho	1122	21	Berlin	Berlin	NNP
cord-006229-7yoilsho	1122	22	to	to	TO
cord-006229-7yoilsho	1122	23	further	further	RB
cord-006229-7yoilsho	1122	24	promote	promote	VB
cord-006229-7yoilsho	1122	25	research	research	NN
cord-006229-7yoilsho	1122	26	on	on	IN
cord-006229-7yoilsho	1122	27	alternative	alternative	JJ
cord-006229-7yoilsho	1122	28	testing	testing	NN
cord-006229-7yoilsho	1122	29	.	.	.
cord-006229-7yoilsho	1123	1	Finally	finally	RB
cord-006229-7yoilsho	1123	2	,	,	,
cord-006229-7yoilsho	1123	3	co	co	NNS
cord-006229-7yoilsho	1123	4	-	-	NNS
cord-006229-7yoilsho	1123	5	operations	operation	NNS
cord-006229-7yoilsho	1123	6	with	with	IN
cord-006229-7yoilsho	1123	7	national	national	JJ
cord-006229-7yoilsho	1123	8	and	and	CC
cord-006229-7yoilsho	1123	9	international	international	JJ
cord-006229-7yoilsho	1123	10	partners	partner	NNS
cord-006229-7yoilsho	1123	11	are	be	VBP
cord-006229-7yoilsho	1123	12	being	be	VBG
cord-006229-7yoilsho	1123	13	built	build	VBN
cord-006229-7yoilsho	1123	14	to	to	TO
cord-006229-7yoilsho	1123	15	facilitate	facilitate	VB
cord-006229-7yoilsho	1123	16	the	the	DT
cord-006229-7yoilsho	1123	17	project	project	NN
cord-006229-7yoilsho	1123	18	-	-	HYPH
cord-006229-7yoilsho	1123	19	based	base	VBN
cord-006229-7yoilsho	1123	20	exchange	exchange	NN
cord-006229-7yoilsho	1123	21	of	of	IN
cord-006229-7yoilsho	1123	22	scientists	scientist	NNS
cord-006229-7yoilsho	1123	23	and	and	CC
cord-006229-7yoilsho	1123	24	joint	joint	JJ
cord-006229-7yoilsho	1123	25	research	research	NN
cord-006229-7yoilsho	1123	26	.	.	.
cord-006229-7yoilsho	1124	1	Currently	currently	RB
cord-006229-7yoilsho	1124	2	,	,	,
cord-006229-7yoilsho	1124	3	the	the	DT
cord-006229-7yoilsho	1124	4	identification	identification	NN
cord-006229-7yoilsho	1124	5	and	and	CC
cord-006229-7yoilsho	1124	6	evaluation	evaluation	NN
cord-006229-7yoilsho	1124	7	of	of	IN
cord-006229-7yoilsho	1124	8	skin	skin	NN
cord-006229-7yoilsho	1124	9	sensitizers	sensitizer	NNS
cord-006229-7yoilsho	1124	10	is	be	VBZ
cord-006229-7yoilsho	1124	11	mainly	mainly	RB
cord-006229-7yoilsho	1124	12	restricted	restrict	VBN
cord-006229-7yoilsho	1124	13	to	to	IN
cord-006229-7yoilsho	1124	14	animal	animal	NN
cord-006229-7yoilsho	1124	15	testing	testing	NN
cord-006229-7yoilsho	1124	16	using	use	VBG
cord-006229-7yoilsho	1124	17	the	the	DT
cord-006229-7yoilsho	1124	18	Guinea	Guinea	NNP
cord-006229-7yoilsho	1124	19	Pig	Pig	NNP
cord-006229-7yoilsho	1124	20	maximization	maximization	NN
cord-006229-7yoilsho	1124	21	test	test	NN
cord-006229-7yoilsho	1124	22	,	,	,
cord-006229-7yoilsho	1124	23	Buehler	Buehler	NNP
cord-006229-7yoilsho	1124	24	test	test	NN
cord-006229-7yoilsho	1124	25	or	or	CC
cord-006229-7yoilsho	1124	26	the	the	DT
cord-006229-7yoilsho	1124	27	murine	murine	JJ
cord-006229-7yoilsho	1124	28	local	local	JJ
cord-006229-7yoilsho	1124	29	lymph	lymph	NN
cord-006229-7yoilsho	1124	30	node	node	NN
cord-006229-7yoilsho	1124	31	assay	assay	NN
cord-006229-7yoilsho	1124	32	.	.	.
cord-006229-7yoilsho	1125	1	Recently	recently	RB
cord-006229-7yoilsho	1125	2	,	,	,
cord-006229-7yoilsho	1125	3	an	an	DT
cord-006229-7yoilsho	1125	4	adverse	adverse	JJ
cord-006229-7yoilsho	1125	5	outcome	outcome	NN
cord-006229-7yoilsho	1125	6	pathway	pathway	NN
cord-006229-7yoilsho	1125	7	of	of	IN
cord-006229-7yoilsho	1125	8	skin	skin	NN
cord-006229-7yoilsho	1125	9	sensitization	sensitization	NN
cord-006229-7yoilsho	1125	10	has	have	VBZ
cord-006229-7yoilsho	1125	11	been	be	VBN
cord-006229-7yoilsho	1125	12	released	release	VBN
cord-006229-7yoilsho	1125	13	by	by	IN
cord-006229-7yoilsho	1125	14	the	the	DT
cord-006229-7yoilsho	1125	15	OECD	OECD	NNP
cord-006229-7yoilsho	1125	16	,	,	,
cord-006229-7yoilsho	1125	17	identifying	identify	VBG
cord-006229-7yoilsho	1125	18	the	the	DT
cord-006229-7yoilsho	1125	19	key	key	JJ
cord-006229-7yoilsho	1125	20	events	event	NNS
cord-006229-7yoilsho	1125	21	leading	lead	VBG
cord-006229-7yoilsho	1125	22	to	to	IN
cord-006229-7yoilsho	1125	23	allergic	allergic	JJ
cord-006229-7yoilsho	1125	24	contact	contact	NN
cord-006229-7yoilsho	1125	25	dermatitis	dermatitis	NN
cord-006229-7yoilsho	1125	26	.	.	.
cord-006229-7yoilsho	1126	1	In	in	IN
cord-006229-7yoilsho	1126	2	vitro	vitro	FW
cord-006229-7yoilsho	1126	3	tests	test	NNS
cord-006229-7yoilsho	1126	4	address	address	VBP
cord-006229-7yoilsho	1126	5	these	these	DT
cord-006229-7yoilsho	1126	6	key	key	JJ
cord-006229-7yoilsho	1126	7	events	event	NNS
cord-006229-7yoilsho	1126	8	and	and	CC
cord-006229-7yoilsho	1126	9	two	two	CD
cord-006229-7yoilsho	1126	10	assays	assay	NNS
cord-006229-7yoilsho	1126	11	are	be	VBP
cord-006229-7yoilsho	1126	12	now	now	RB
cord-006229-7yoilsho	1126	13	regulatory	regulatory	JJ
cord-006229-7yoilsho	1126	14	adopted	adopt	VBN
cord-006229-7yoilsho	1126	15	(	(	-LRB-
cord-006229-7yoilsho	1126	16	OECD	OECD	NNP
cord-006229-7yoilsho	1126	17	442C	442C	NNP
cord-006229-7yoilsho	1126	18	and	and	CC
cord-006229-7yoilsho	1126	19	442D	442d	CD
cord-006229-7yoilsho	1126	20	)	)	-RRB-
cord-006229-7yoilsho	1126	21	.	.	.
cord-006229-7yoilsho	1127	1	The	the	DT
cord-006229-7yoilsho	1127	2	use	use	NN
cord-006229-7yoilsho	1127	3	of	of	IN
cord-006229-7yoilsho	1127	4	the	the	DT
cord-006229-7yoilsho	1127	5	current	current	NN
cord-006229-7yoilsho	1127	6	in	in	IN
cord-006229-7yoilsho	1127	7	chemico	chemico	NN
cord-006229-7yoilsho	1127	8	and	and	CC
cord-006229-7yoilsho	1127	9	in	in	IN
cord-006229-7yoilsho	1127	10	vitro	vitro	FW
cord-006229-7yoilsho	1127	11	models	model	NNS
cord-006229-7yoilsho	1127	12	is	be	VBZ
cord-006229-7yoilsho	1127	13	,	,	,
cord-006229-7yoilsho	1127	14	however	however	RB
cord-006229-7yoilsho	1127	15	,	,	,
cord-006229-7yoilsho	1127	16	limited	limit	VBN
cord-006229-7yoilsho	1127	17	since	since	IN
cord-006229-7yoilsho	1127	18	they	-PRON-	PRP
cord-006229-7yoilsho	1127	19	do	do	VBP
cord-006229-7yoilsho	1127	20	not	not	RB
cord-006229-7yoilsho	1127	21	reflect	reflect	VB
cord-006229-7yoilsho	1127	22	dermal	dermal	JJ
cord-006229-7yoilsho	1127	23	penetration	penetration	NN
cord-006229-7yoilsho	1127	24	,	,	,
cord-006229-7yoilsho	1127	25	complete	complete	JJ
cord-006229-7yoilsho	1127	26	biotransformation	biotransformation	NN
cord-006229-7yoilsho	1127	27	and	and	CC
cord-006229-7yoilsho	1127	28	cell	cell	NN
cord-006229-7yoilsho	1127	29	cross	cross	NN
cord-006229-7yoilsho	1127	30	-	-	NN
cord-006229-7yoilsho	1127	31	talk	talk	NN
cord-006229-7yoilsho	1127	32	in	in	IN
cord-006229-7yoilsho	1127	33	an	an	DT
cord-006229-7yoilsho	1127	34	organotypic	organotypic	JJ
cord-006229-7yoilsho	1127	35	environment	environment	NN
cord-006229-7yoilsho	1127	36	.	.	.
cord-006229-7yoilsho	1128	1	In	in	IN
cord-006229-7yoilsho	1128	2	this	this	DT
cord-006229-7yoilsho	1128	3	study	study	NN
cord-006229-7yoilsho	1128	4	,	,	,
cord-006229-7yoilsho	1128	5	we	-PRON-	PRP
cord-006229-7yoilsho	1128	6	aimed	aim	VBD
cord-006229-7yoilsho	1128	7	to	to	TO
cord-006229-7yoilsho	1128	8	overcome	overcome	VB
cord-006229-7yoilsho	1128	9	these	these	DT
cord-006229-7yoilsho	1128	10	limitations	limitation	NNS
cord-006229-7yoilsho	1128	11	by	by	IN
cord-006229-7yoilsho	1128	12	establishing	establish	VBG
cord-006229-7yoilsho	1128	13	reconstructed	reconstruct	VBN
cord-006229-7yoilsho	1128	14	skin	skin	NN
cord-006229-7yoilsho	1128	15	tissues	tissue	NNS
cord-006229-7yoilsho	1128	16	containing	contain	VBG
cord-006229-7yoilsho	1128	17	Langerhans	Langerhans	NNP
cord-006229-7yoilsho	1128	18	cells	cell	NNS
cord-006229-7yoilsho	1128	19	(	(	-LRB-
cord-006229-7yoilsho	1128	20	LCs	LCs	NNP
cord-006229-7yoilsho	1128	21	)	)	-RRB-
cord-006229-7yoilsho	1128	22	.	.	.
cord-006229-7yoilsho	1129	1	In	in	IN
cord-006229-7yoilsho	1129	2	vitro	vitro	FW
cord-006229-7yoilsho	1129	3	generated	generate	VBD
cord-006229-7yoilsho	1129	4	immature	immature	JJ
cord-006229-7yoilsho	1129	5	monocyte	monocyte	NN
cord-006229-7yoilsho	1129	6	-	-	HYPH
cord-006229-7yoilsho	1129	7	derived	derive	VBN
cord-006229-7yoilsho	1129	8	(	(	-LRB-
cord-006229-7yoilsho	1129	9	MoLCs	MoLCs	NNP
cord-006229-7yoilsho	1129	10	)	)	-RRB-
cord-006229-7yoilsho	1129	11	or	or	CC
cord-006229-7yoilsho	1129	12	MUTZ-3-derived	mutz-3-derived	JJ
cord-006229-7yoilsho	1129	13	cells	cell	NNS
cord-006229-7yoilsho	1129	14	(	(	-LRB-
cord-006229-7yoilsho	1129	15	MUTZ	MUTZ	NNP
cord-006229-7yoilsho	1129	16	-	-	HYPH
cord-006229-7yoilsho	1129	17	LCs	LCs	NNP
cord-006229-7yoilsho	1129	18	)	)	-RRB-
cord-006229-7yoilsho	1129	19	cultivated	cultivate	VBN
cord-006229-7yoilsho	1129	20	with	with	IN
cord-006229-7yoilsho	1129	21	keratinocytes	keratinocyte	NNS
cord-006229-7yoilsho	1129	22	on	on	IN
cord-006229-7yoilsho	1129	23	a	a	DT
cord-006229-7yoilsho	1129	24	dermal	dermal	JJ
cord-006229-7yoilsho	1129	25	compartment	compartment	NN
cord-006229-7yoilsho	1129	26	with	with	IN
cord-006229-7yoilsho	1129	27	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	1129	28	form	form	VBP
cord-006229-7yoilsho	1129	29	a	a	DT
cord-006229-7yoilsho	1129	30	stratified	stratified	JJ
cord-006229-7yoilsho	1129	31	epidermis	epidermis	NN
cord-006229-7yoilsho	1129	32	after	after	IN
cord-006229-7yoilsho	1129	33	14	14	CD
cord-006229-7yoilsho	1129	34	days	day	NNS
cord-006229-7yoilsho	1129	35	as	as	IN
cord-006229-7yoilsho	1129	36	indicated	indicate	VBN
cord-006229-7yoilsho	1129	37	by	by	IN
cord-006229-7yoilsho	1129	38	the	the	DT
cord-006229-7yoilsho	1129	39	expression	expression	NN
cord-006229-7yoilsho	1129	40	of	of	IN
cord-006229-7yoilsho	1129	41	epidermal	epidermal	JJ
cord-006229-7yoilsho	1129	42	differentiation	differentiation	NN
cord-006229-7yoilsho	1129	43	markers	marker	NNS
cord-006229-7yoilsho	1129	44	.	.	.
cord-006229-7yoilsho	1130	1	MoLCs	MoLCs	NNP
cord-006229-7yoilsho	1130	2	or	or	CC
cord-006229-7yoilsho	1130	3	MUTZ	MUTZ	NNP
cord-006229-7yoilsho	1130	4	-	-	HYPH
cord-006229-7yoilsho	1130	5	LCs	LCs	NNP
cord-006229-7yoilsho	1130	6	were	be	VBD
cord-006229-7yoilsho	1130	7	mainly	mainly	RB
cord-006229-7yoilsho	1130	8	localized	localize	VBN
cord-006229-7yoilsho	1130	9	in	in	IN
cord-006229-7yoilsho	1130	10	suprabasal	suprabasal	NN
cord-006229-7yoilsho	1130	11	layers	layer	NNS
cord-006229-7yoilsho	1130	12	of	of	IN
cord-006229-7yoilsho	1130	13	the	the	DT
cord-006229-7yoilsho	1130	14	epidermis	epidermis	NN
cord-006229-7yoilsho	1130	15	and	and	CC
cord-006229-7yoilsho	1130	16	distributed	distribute	VBN
cord-006229-7yoilsho	1130	17	homogeneously	homogeneously	RB
cord-006229-7yoilsho	1130	18	in	in	IN
cord-006229-7yoilsho	1130	19	accordance	accordance	NN
cord-006229-7yoilsho	1130	20	with	with	IN
cord-006229-7yoilsho	1130	21	native	native	JJ
cord-006229-7yoilsho	1130	22	human	human	JJ
cord-006229-7yoilsho	1130	23	skin	skin	NN
cord-006229-7yoilsho	1130	24	.	.	.
cord-006229-7yoilsho	1131	1	Topical	topical	JJ
cord-006229-7yoilsho	1131	2	application	application	NN
cord-006229-7yoilsho	1131	3	of	of	IN
cord-006229-7yoilsho	1131	4	the	the	DT
cord-006229-7yoilsho	1131	5	extreme	extreme	JJ
cord-006229-7yoilsho	1131	6	contact	contact	NN
cord-006229-7yoilsho	1131	7	sensitizer	sensitizer	NN
cord-006229-7yoilsho	1131	8	2,4-dinitrochlorobenzene	2,4-dinitrochlorobenzene	CD
cord-006229-7yoilsho	1131	9	(	(	-LRB-
cord-006229-7yoilsho	1131	10	DNCB	DNCB	NNP
cord-006229-7yoilsho	1131	11	)	)	-RRB-
cord-006229-7yoilsho	1131	12	induced	induce	VBN
cord-006229-7yoilsho	1131	13	IL-6	IL-6	NNP
cord-006229-7yoilsho	1131	14	and	and	CC
cord-006229-7yoilsho	1131	15	IL-8	IL-8	NNP
cord-006229-7yoilsho	1131	16	secretion	secretion	NN
cord-006229-7yoilsho	1131	17	in	in	IN
cord-006229-7yoilsho	1131	18	skin	skin	NN
cord-006229-7yoilsho	1131	19	models	model	NNS
cord-006229-7yoilsho	1131	20	with	with	IN
cord-006229-7yoilsho	1131	21	LC	LC	NNP
cord-006229-7yoilsho	1131	22	-	-	HYPH
cord-006229-7yoilsho	1131	23	like	like	JJ
cord-006229-7yoilsho	1131	24	cells	cell	NNS
cord-006229-7yoilsho	1131	25	,	,	,
cord-006229-7yoilsho	1131	26	whereas	whereas	IN
cord-006229-7yoilsho	1131	27	no	no	DT
cord-006229-7yoilsho	1131	28	change	change	NN
cord-006229-7yoilsho	1131	29	was	be	VBD
cord-006229-7yoilsho	1131	30	observed	observe	VBN
cord-006229-7yoilsho	1131	31	in	in	IN
cord-006229-7yoilsho	1131	32	control	control	NN
cord-006229-7yoilsho	1131	33	RHS	RHS	NNP
cord-006229-7yoilsho	1131	34	lacking	lack	VBG
cord-006229-7yoilsho	1131	35	immune	immune	JJ
cord-006229-7yoilsho	1131	36	cells	cell	NNS
cord-006229-7yoilsho	1131	37	.	.	.
cord-006229-7yoilsho	1132	1	Increased	increase	VBN
cord-006229-7yoilsho	1132	2	gene	gene	NN
cord-006229-7yoilsho	1132	3	expression	expression	NN
cord-006229-7yoilsho	1132	4	of	of	IN
cord-006229-7yoilsho	1132	5	CD83	CD83	NNP
cord-006229-7yoilsho	1132	6	and	and	CC
cord-006229-7yoilsho	1132	7	PD	PD	NNP
cord-006229-7yoilsho	1132	8	-	-	HYPH
cord-006229-7yoilsho	1132	9	L1	L1	NNP
cord-006229-7yoilsho	1132	10	in	in	IN
cord-006229-7yoilsho	1132	11	the	the	DT
cord-006229-7yoilsho	1132	12	dermal	dermal	JJ
cord-006229-7yoilsho	1132	13	compartment	compartment	NN
cord-006229-7yoilsho	1132	14	indicated	indicate	VBD
cord-006229-7yoilsho	1132	15	LC	LC	NNP
cord-006229-7yoilsho	1132	16	maturation	maturation	NN
cord-006229-7yoilsho	1132	17	.	.	.
cord-006229-7yoilsho	1133	1	We	-PRON-	PRP
cord-006229-7yoilsho	1133	2	confirmed	confirm	VBD
cord-006229-7yoilsho	1133	3	the	the	DT
cord-006229-7yoilsho	1133	4	enhanced	enhanced	JJ
cord-006229-7yoilsho	1133	5	mobility	mobility	NN
cord-006229-7yoilsho	1133	6	from	from	IN
cord-006229-7yoilsho	1133	7	epidermal	epidermal	JJ
cord-006229-7yoilsho	1133	8	to	to	IN
cord-006229-7yoilsho	1133	9	dermal	dermal	JJ
cord-006229-7yoilsho	1133	10	compartments	compartment	NNS
cord-006229-7yoilsho	1133	11	for	for	IN
cord-006229-7yoilsho	1133	12	MUTZ	MUTZ	NNP
cord-006229-7yoilsho	1133	13	-	-	HYPH
cord-006229-7yoilsho	1133	14	LCs	LCs	NNP
cord-006229-7yoilsho	1133	15	and	and	CC
cord-006229-7yoilsho	1133	16	MoLCs	MoLCs	NNP
cord-006229-7yoilsho	1133	17	in	in	IN
cord-006229-7yoilsho	1133	18	the	the	DT
cord-006229-7yoilsho	1133	19	presence	presence	NN
cord-006229-7yoilsho	1133	20	of	of	IN
cord-006229-7yoilsho	1133	21	DNCB	DNCB	NNP
cord-006229-7yoilsho	1133	22	.	.	.
cord-006229-7yoilsho	1134	1	In	in	IN
cord-006229-7yoilsho	1134	2	summary	summary	NN
cord-006229-7yoilsho	1134	3	,	,	,
cord-006229-7yoilsho	1134	4	we	-PRON-	PRP
cord-006229-7yoilsho	1134	5	successfully	successfully	RB
cord-006229-7yoilsho	1134	6	integrated	integrate	VBD
cord-006229-7yoilsho	1134	7	immature	immature	JJ
cord-006229-7yoilsho	1134	8	and	and	CC
cord-006229-7yoilsho	1134	9	functional	functional	JJ
cord-006229-7yoilsho	1134	10	LC	LC	NNP
cord-006229-7yoilsho	1134	11	-	-	HYPH
cord-006229-7yoilsho	1134	12	like	like	JJ
cord-006229-7yoilsho	1134	13	cells	cell	NNS
cord-006229-7yoilsho	1134	14	into	into	IN
cord-006229-7yoilsho	1134	15	reconstructed	reconstruct	VBN
cord-006229-7yoilsho	1134	16	human	human	JJ
cord-006229-7yoilsho	1134	17	skin	skin	NN
cord-006229-7yoilsho	1134	18	.	.	.
cord-006229-7yoilsho	1135	1	This	this	DT
cord-006229-7yoilsho	1135	2	fosters	foster	VBZ
cord-006229-7yoilsho	1135	3	the	the	DT
cord-006229-7yoilsho	1135	4	development	development	NN
cord-006229-7yoilsho	1135	5	of	of	IN
cord-006229-7yoilsho	1135	6	animal	animal	NN
cord-006229-7yoilsho	1135	7	-	-	HYPH
cord-006229-7yoilsho	1135	8	free	free	JJ
cord-006229-7yoilsho	1135	9	test	test	NN
cord-006229-7yoilsho	1135	10	systems	system	NNS
cord-006229-7yoilsho	1135	11	for	for	IN
cord-006229-7yoilsho	1135	12	advanced	advanced	JJ
cord-006229-7yoilsho	1135	13	and	and	CC
cord-006229-7yoilsho	1135	14	potentially	potentially	RB
cord-006229-7yoilsho	1135	15	individualized	individualized	JJ
cord-006229-7yoilsho	1135	16	hazard	hazard	NN
cord-006229-7yoilsho	1135	17	assessment	assessment	NN
cord-006229-7yoilsho	1135	18	of	of	IN
cord-006229-7yoilsho	1135	19	skin	skin	NN
cord-006229-7yoilsho	1135	20	sensitization	sensitization	NN
cord-006229-7yoilsho	1135	21	.	.	.
cord-006229-7yoilsho	1136	1	Computational	computational	JJ
cord-006229-7yoilsho	1136	2	methods	method	NNS
cord-006229-7yoilsho	1136	3	for	for	IN
cord-006229-7yoilsho	1136	4	prediction	prediction	NN
cord-006229-7yoilsho	1136	5	of	of	IN
cord-006229-7yoilsho	1136	6	in	in	FW
cord-006229-7yoilsho	1136	7	vitro	vitro	FW
cord-006229-7yoilsho	1136	8	activity	activity	NN
cord-006229-7yoilsho	1136	9	of	of	IN
cord-006229-7yoilsho	1136	10	new	new	JJ
cord-006229-7yoilsho	1136	11	chemical	chemical	JJ
cord-006229-7yoilsho	1136	12	structures	structure	NNS
cord-006229-7yoilsho	1136	13	.	.	.
cord-006229-7yoilsho	1137	1	Background	background	NN
cord-006229-7yoilsho	1137	2	:	:	:
cord-006229-7yoilsho	1138	1	With	with	IN
cord-006229-7yoilsho	1138	2	a	a	DT
cord-006229-7yoilsho	1138	3	constant	constant	JJ
cord-006229-7yoilsho	1138	4	increase	increase	NN
cord-006229-7yoilsho	1138	5	in	in	IN
cord-006229-7yoilsho	1138	6	the	the	DT
cord-006229-7yoilsho	1138	7	number	number	NN
cord-006229-7yoilsho	1138	8	of	of	IN
cord-006229-7yoilsho	1138	9	new	new	JJ
cord-006229-7yoilsho	1138	10	chemicals	chemical	NNS
cord-006229-7yoilsho	1138	11	synthesized	synthesize	VBN
cord-006229-7yoilsho	1138	12	every	every	DT
cord-006229-7yoilsho	1138	13	year	year	NN
cord-006229-7yoilsho	1138	14	,	,	,
cord-006229-7yoilsho	1138	15	it	-PRON-	PRP
cord-006229-7yoilsho	1138	16	becomes	become	VBZ
cord-006229-7yoilsho	1138	17	highly	highly	RB
cord-006229-7yoilsho	1138	18	important	important	JJ
cord-006229-7yoilsho	1138	19	to	to	TO
cord-006229-7yoilsho	1138	20	employ	employ	VB
cord-006229-7yoilsho	1138	21	the	the	DT
cord-006229-7yoilsho	1138	22	most	most	RBS
cord-006229-7yoilsho	1138	23	reliable	reliable	JJ
cord-006229-7yoilsho	1138	24	and	and	CC
cord-006229-7yoilsho	1138	25	fast	fast	JJ
cord-006229-7yoilsho	1138	26	in	in	IN
cord-006229-7yoilsho	1138	27	silico	silico	NN
cord-006229-7yoilsho	1138	28	screening	screening	NN
cord-006229-7yoilsho	1138	29	methods	method	NNS
cord-006229-7yoilsho	1138	30	to	to	TO
cord-006229-7yoilsho	1138	31	predict	predict	VB
cord-006229-7yoilsho	1138	32	their	-PRON-	PRP$
cord-006229-7yoilsho	1138	33	safety	safety	NN
cord-006229-7yoilsho	1138	34	and	and	CC
cord-006229-7yoilsho	1138	35	activity	activity	NN
cord-006229-7yoilsho	1138	36	profiles	profile	NNS
cord-006229-7yoilsho	1138	37	.	.	.
cord-006229-7yoilsho	1139	1	In	in	IN
cord-006229-7yoilsho	1139	2	recent	recent	JJ
cord-006229-7yoilsho	1139	3	years	year	NNS
cord-006229-7yoilsho	1139	4	,	,	,
cord-006229-7yoilsho	1139	5	in	in	IN
cord-006229-7yoilsho	1139	6	silico	silico	NN
cord-006229-7yoilsho	1139	7	prediction	prediction	NN
cord-006229-7yoilsho	1139	8	methods	method	NNS
cord-006229-7yoilsho	1139	9	received	receive	VBD
cord-006229-7yoilsho	1139	10	great	great	JJ
cord-006229-7yoilsho	1139	11	attention	attention	NN
cord-006229-7yoilsho	1139	12	as	as	IN
cord-006229-7yoilsho	1139	13	alternatives	alternative	NNS
cord-006229-7yoilsho	1139	14	to	to	IN
cord-006229-7yoilsho	1139	15	animal	animal	NN
cord-006229-7yoilsho	1139	16	experiments	experiment	NNS
cord-006229-7yoilsho	1139	17	for	for	IN
cord-006229-7yoilsho	1139	18	evaluation	evaluation	NN
cord-006229-7yoilsho	1139	19	of	of	IN
cord-006229-7yoilsho	1139	20	various	various	JJ
cord-006229-7yoilsho	1139	21	toxicological	toxicological	JJ
cord-006229-7yoilsho	1139	22	endpoints	endpoint	NNS
cord-006229-7yoilsho	1139	23	,	,	,
cord-006229-7yoilsho	1139	24	complementing	complement	VBG
cord-006229-7yoilsho	1139	25	the	the	DT
cord-006229-7yoilsho	1139	26	theme	theme	NN
cord-006229-7yoilsho	1139	27	of	of	IN
cord-006229-7yoilsho	1139	28	Replace	Replace	NNP
cord-006229-7yoilsho	1139	29	,	,	,
cord-006229-7yoilsho	1139	30	Reduce	reduce	VB
cord-006229-7yoilsho	1139	31	and	and	CC
cord-006229-7yoilsho	1139	32	Refine	refine	VB
cord-006229-7yoilsho	1139	33	(	(	-LRB-
cord-006229-7yoilsho	1139	34	3Rs	3Rs	NNP
cord-006229-7yoilsho	1139	35	)	)	-RRB-
cord-006229-7yoilsho	1139	36	.	.	.
cord-006229-7yoilsho	1140	1	Various	various	JJ
cord-006229-7yoilsho	1140	2	computational	computational	JJ
cord-006229-7yoilsho	1140	3	approaches	approach	NNS
cord-006229-7yoilsho	1140	4	have	have	VBP
cord-006229-7yoilsho	1140	5	been	be	VBN
cord-006229-7yoilsho	1140	6	proposed	propose	VBN
cord-006229-7yoilsho	1140	7	for	for	IN
cord-006229-7yoilsho	1140	8	prediction	prediction	NN
cord-006229-7yoilsho	1140	9	of	of	IN
cord-006229-7yoilsho	1140	10	toxicity	toxicity	NN
cord-006229-7yoilsho	1140	11	of	of	IN
cord-006229-7yoilsho	1140	12	chemicals	chemical	NNS
cord-006229-7yoilsho	1140	13	ranging	range	VBG
cord-006229-7yoilsho	1140	14	from	from	IN
cord-006229-7yoilsho	1140	15	quantitative	quantitative	JJ
cord-006229-7yoilsho	1140	16	structure	structure	NN
cord-006229-7yoilsho	1140	17	activity	activity	NN
cord-006229-7yoilsho	1140	18	relationship	relationship	NN
cord-006229-7yoilsho	1140	19	modeling	model	VBG
cord-006229-7yoilsho	1140	20	to	to	IN
cord-006229-7yoilsho	1140	21	molecular	molecular	JJ
cord-006229-7yoilsho	1140	22	similarity	similarity	NN
cord-006229-7yoilsho	1140	23	based	base	VBN
cord-006229-7yoilsho	1140	24	methods	method	NNS
cord-006229-7yoilsho	1140	25	and	and	CC
cord-006229-7yoilsho	1140	26	machine	machine	NN
cord-006229-7yoilsho	1140	27	-	-	HYPH
cord-006229-7yoilsho	1140	28	learning	learn	VBG
cord-006229-7yoilsho	1140	29	methods	method	NNS
cord-006229-7yoilsho	1140	30	.	.	.
cord-006229-7yoilsho	1141	1	Within	within	IN
cord-006229-7yoilsho	1141	2	the	the	DT
cord-006229-7yoilsho	1141	3	"	"	``
cord-006229-7yoilsho	1141	4	Toxicology	Toxicology	NNP
cord-006229-7yoilsho	1141	5	in	in	IN
cord-006229-7yoilsho	1141	6	the	the	DT
cord-006229-7yoilsho	1141	7	21st	21st	JJ
cord-006229-7yoilsho	1141	8	Century	Century	NNP
cord-006229-7yoilsho	1141	9	"	"	''
cord-006229-7yoilsho	1141	10	screening	screening	NN
cord-006229-7yoilsho	1141	11	initiative	initiative	NN
cord-006229-7yoilsho	1141	12	,	,	,
cord-006229-7yoilsho	1141	13	a	a	DT
cord-006229-7yoilsho	1141	14	crowdsourced	crowdsourced	JJ
cord-006229-7yoilsho	1141	15	platform	platform	NN
cord-006229-7yoilsho	1141	16	was	be	VBD
cord-006229-7yoilsho	1141	17	established	establish	VBN
cord-006229-7yoilsho	1141	18	for	for	IN
cord-006229-7yoilsho	1141	19	development	development	NN
cord-006229-7yoilsho	1141	20	and	and	CC
cord-006229-7yoilsho	1141	21	validation	validation	NN
cord-006229-7yoilsho	1141	22	of	of	IN
cord-006229-7yoilsho	1141	23	computational	computational	JJ
cord-006229-7yoilsho	1141	24	models	model	NNS
cord-006229-7yoilsho	1141	25	to	to	TO
cord-006229-7yoilsho	1141	26	predict	predict	VB
cord-006229-7yoilsho	1141	27	the	the	DT
cord-006229-7yoilsho	1141	28	interference	interference	NN
cord-006229-7yoilsho	1141	29	of	of	IN
cord-006229-7yoilsho	1141	30	chemical	chemical	JJ
cord-006229-7yoilsho	1141	31	compounds	compound	NNS
cord-006229-7yoilsho	1141	32	in	in	IN
cord-006229-7yoilsho	1141	33	nuclear	nuclear	JJ
cord-006229-7yoilsho	1141	34	and	and	CC
cord-006229-7yoilsho	1141	35	stress	stress	NN
cord-006229-7yoilsho	1141	36	receptor	receptor	NN
cord-006229-7yoilsho	1141	37	pathways	pathway	NNS
cord-006229-7yoilsho	1141	38	based	base	VBN
cord-006229-7yoilsho	1141	39	on	on	IN
cord-006229-7yoilsho	1141	40	a	a	DT
cord-006229-7yoilsho	1141	41	training	training	NN
cord-006229-7yoilsho	1141	42	set	set	NN
cord-006229-7yoilsho	1141	43	containing	contain	VBG
cord-006229-7yoilsho	1141	44	more	more	JJR
cord-006229-7yoilsho	1141	45	than	than	IN
cord-006229-7yoilsho	1141	46	10,000	10,000	CD
cord-006229-7yoilsho	1141	47	compounds	compound	NNS
cord-006229-7yoilsho	1141	48	tested	test	VBN
cord-006229-7yoilsho	1141	49	in	in	IN
cord-006229-7yoilsho	1141	50	high	high	JJ
cord-006229-7yoilsho	1141	51	-	-	HYPH
cord-006229-7yoilsho	1141	52	throughput	throughput	NN
cord-006229-7yoilsho	1141	53	screening	screening	NN
cord-006229-7yoilsho	1141	54	assays	assay	NNS
cord-006229-7yoilsho	1141	55	.	.	.
cord-006229-7yoilsho	1142	1	Methods	method	NNS
cord-006229-7yoilsho	1142	2	:	:	:
cord-006229-7yoilsho	1143	1	Here	here	RB
cord-006229-7yoilsho	1143	2	we	-PRON-	PRP
cord-006229-7yoilsho	1143	3	present	present	VBP
cord-006229-7yoilsho	1143	4	the	the	DT
cord-006229-7yoilsho	1143	5	results	result	NNS
cord-006229-7yoilsho	1143	6	of	of	IN
cord-006229-7yoilsho	1143	7	various	various	JJ
cord-006229-7yoilsho	1143	8	molecular	molecular	JJ
cord-006229-7yoilsho	1143	9	similarity	similarity	NN
cord-006229-7yoilsho	1143	10	-	-	HYPH
cord-006229-7yoilsho	1143	11	based	base	VBN
cord-006229-7yoilsho	1143	12	and	and	CC
cord-006229-7yoilsho	1143	13	machine	machine	NN
cord-006229-7yoilsho	1143	14	-	-	HYPH
cord-006229-7yoilsho	1143	15	learning	learning	NN
cord-006229-7yoilsho	1143	16	-	-	HYPH
cord-006229-7yoilsho	1143	17	based	base	VBN
cord-006229-7yoilsho	1143	18	methods	method	NNS
cord-006229-7yoilsho	1143	19	over	over	IN
cord-006229-7yoilsho	1143	20	an	an	DT
cord-006229-7yoilsho	1143	21	independent	independent	JJ
cord-006229-7yoilsho	1143	22	evaluation	evaluation	NN
cord-006229-7yoilsho	1143	23	set	set	NN
cord-006229-7yoilsho	1143	24	containing	contain	VBG
cord-006229-7yoilsho	1143	25	647	647	CD
cord-006229-7yoilsho	1143	26	compounds	compound	NNS
cord-006229-7yoilsho	1143	27	.	.	.
cord-006229-7yoilsho	1144	1	Further	further	RB
cord-006229-7yoilsho	1144	2	,	,	,
cord-006229-7yoilsho	1144	3	we	-PRON-	PRP
cord-006229-7yoilsho	1144	4	compare	compare	VBP
cord-006229-7yoilsho	1144	5	the	the	DT
cord-006229-7yoilsho	1144	6	performance	performance	NN
cord-006229-7yoilsho	1144	7	of	of	IN
cord-006229-7yoilsho	1144	8	these	these	DT
cord-006229-7yoilsho	1144	9	methods	method	NNS
cord-006229-7yoilsho	1144	10	when	when	WRB
cord-006229-7yoilsho	1144	11	applied	apply	VBN
cord-006229-7yoilsho	1144	12	individually	individually	RB
cord-006229-7yoilsho	1144	13	and	and	CC
cord-006229-7yoilsho	1144	14	together	together	RB
cord-006229-7yoilsho	1144	15	.	.	.
cord-006229-7yoilsho	1145	1	In	in	IN
cord-006229-7yoilsho	1145	2	retrospect	retrospect	NN
cord-006229-7yoilsho	1145	3	we	-PRON-	PRP
cord-006229-7yoilsho	1145	4	also	also	RB
cord-006229-7yoilsho	1145	5	discuss	discuss	VBP
cord-006229-7yoilsho	1145	6	the	the	DT
cord-006229-7yoilsho	1145	7	reasons	reason	NNS
cord-006229-7yoilsho	1145	8	behind	behind	IN
cord-006229-7yoilsho	1145	9	the	the	DT
cord-006229-7yoilsho	1145	10	superior	superior	JJ
cord-006229-7yoilsho	1145	11	performance	performance	NN
cord-006229-7yoilsho	1145	12	of	of	IN
cord-006229-7yoilsho	1145	13	an	an	DT
cord-006229-7yoilsho	1145	14	ensemble	ensemble	NN
cord-006229-7yoilsho	1145	15	approach	approach	NN
cord-006229-7yoilsho	1145	16	,	,	,
cord-006229-7yoilsho	1145	17	that	that	DT
cord-006229-7yoilsho	1145	18	combines	combine	VBZ
cord-006229-7yoilsho	1145	19	a	a	DT
cord-006229-7yoilsho	1145	20	molecular	molecular	JJ
cord-006229-7yoilsho	1145	21	similarity	similarity	NN
cord-006229-7yoilsho	1145	22	approach	approach	NN
cord-006229-7yoilsho	1145	23	and	and	CC
cord-006229-7yoilsho	1145	24	a	a	DT
cord-006229-7yoilsho	1145	25	naïve	naïve	JJ
cord-006229-7yoilsho	1145	26	Bayes	Bayes	NNP
cord-006229-7yoilsho	1145	27	machine	machine	NN
cord-006229-7yoilsho	1145	28	learning	learning	NN
cord-006229-7yoilsho	1145	29	algorithm	algorithm	NN
cord-006229-7yoilsho	1145	30	in	in	IN
cord-006229-7yoilsho	1145	31	achieving	achieve	VBG
cord-006229-7yoilsho	1145	32	best	good	JJS
cord-006229-7yoilsho	1145	33	prediction	prediction	NN
cord-006229-7yoilsho	1145	34	rates	rate	NNS
cord-006229-7yoilsho	1145	35	in	in	IN
cord-006229-7yoilsho	1145	36	comparison	comparison	NN
cord-006229-7yoilsho	1145	37	with	with	IN
cord-006229-7yoilsho	1145	38	other	other	JJ
cord-006229-7yoilsho	1145	39	individual	individual	JJ
cord-006229-7yoilsho	1145	40	methods	method	NNS
cord-006229-7yoilsho	1145	41	,	,	,
cord-006229-7yoilsho	1145	42	explaining	explain	VBG
cord-006229-7yoilsho	1145	43	their	-PRON-	PRP$
cord-006229-7yoilsho	1145	44	intrinsic	intrinsic	JJ
cord-006229-7yoilsho	1145	45	limitations	limitation	NNS
cord-006229-7yoilsho	1145	46	.	.	.
cord-006229-7yoilsho	1146	1	Results	result	NNS
cord-006229-7yoilsho	1146	2	and	and	CC
cord-006229-7yoilsho	1146	3	Conclusions	conclusion	NNS
cord-006229-7yoilsho	1146	4	:	:	:
cord-006229-7yoilsho	1147	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	1147	2	results	result	NNS
cord-006229-7yoilsho	1147	3	suggest	suggest	VBP
cord-006229-7yoilsho	1147	4	that	that	IN
cord-006229-7yoilsho	1147	5	,	,	,
cord-006229-7yoilsho	1147	6	although	although	IN
cord-006229-7yoilsho	1147	7	prediction	prediction	NN
cord-006229-7yoilsho	1147	8	methods	method	NNS
cord-006229-7yoilsho	1147	9	were	be	VBD
cord-006229-7yoilsho	1147	10	optimized	optimize	VBN
cord-006229-7yoilsho	1147	11	individually	individually	RB
cord-006229-7yoilsho	1147	12	for	for	IN
cord-006229-7yoilsho	1147	13	each	each	DT
cord-006229-7yoilsho	1147	14	modeled	model	VBN
cord-006229-7yoilsho	1147	15	target	target	NN
cord-006229-7yoilsho	1147	16	,	,	,
cord-006229-7yoilsho	1147	17	an	an	DT
cord-006229-7yoilsho	1147	18	ensemble	ensemble	NN
cord-006229-7yoilsho	1147	19	of	of	IN
cord-006229-7yoilsho	1147	20	similarity	similarity	NN
cord-006229-7yoilsho	1147	21	and	and	CC
cord-006229-7yoilsho	1147	22	machinelearning	machinelearning	NN
cord-006229-7yoilsho	1147	23	approaches	approach	NNS
cord-006229-7yoilsho	1147	24	provides	provide	VBZ
cord-006229-7yoilsho	1147	25	promising	promising	JJ
cord-006229-7yoilsho	1147	26	performance	performance	NN
cord-006229-7yoilsho	1147	27	indicating	indicate	VBG
cord-006229-7yoilsho	1147	28	its	-PRON-	PRP$
cord-006229-7yoilsho	1147	29	broad	broad	JJ
cord-006229-7yoilsho	1147	30	applicability	applicability	NN
cord-006229-7yoilsho	1147	31	in	in	IN
cord-006229-7yoilsho	1147	32	toxicity	toxicity	NN
cord-006229-7yoilsho	1147	33	prediction	prediction	NN
cord-006229-7yoilsho	1147	34	.	.	.
cord-006229-7yoilsho	1148	1	Charité	Charité	NNP
cord-006229-7yoilsho	1148	2	-Universitätsmedizin	-Universitätsmedizin	:
cord-006229-7yoilsho	1148	3	Berlin	Berlin	NNP
cord-006229-7yoilsho	1148	4	,	,	,
cord-006229-7yoilsho	1148	5	Structural	Structural	NNP
cord-006229-7yoilsho	1148	6	Bioinformatics	Bioinformatics	NNP
cord-006229-7yoilsho	1148	7	Group	Group	NNP
cord-006229-7yoilsho	1148	8	,	,	,
cord-006229-7yoilsho	1148	9	Berlin	Berlin	NNP
cord-006229-7yoilsho	1148	10	,	,	,
cord-006229-7yoilsho	1148	11	Germany	Germany	NNP
cord-006229-7yoilsho	1149	1	A	a	DT
cord-006229-7yoilsho	1149	2	multitude	multitude	NN
cord-006229-7yoilsho	1149	3	of	of	IN
cord-006229-7yoilsho	1149	4	drug	drug	NN
cord-006229-7yoilsho	1149	5	candidates	candidate	NNS
cord-006229-7yoilsho	1149	6	(	(	-LRB-
cord-006229-7yoilsho	1149	7	approx	approx	NN
cord-006229-7yoilsho	1149	8	.	.	.
cord-006229-7yoilsho	1149	9	20	20	CD
cord-006229-7yoilsho	1149	10	%	%	NN
cord-006229-7yoilsho	1149	11	)	)	-RRB-
cord-006229-7yoilsho	1149	12	fail	fail	VBP
cord-006229-7yoilsho	1149	13	in	in	IN
cord-006229-7yoilsho	1149	14	the	the	DT
cord-006229-7yoilsho	1149	15	late	late	JJ
cord-006229-7yoilsho	1149	16	drug	drug	NN
cord-006229-7yoilsho	1149	17	development	development	NN
cord-006229-7yoilsho	1149	18	due	due	IN
cord-006229-7yoilsho	1149	19	to	to	IN
cord-006229-7yoilsho	1149	20	toxicity	toxicity	NN
cord-006229-7yoilsho	1149	21	and	and	CC
cord-006229-7yoilsho	1149	22	adverse	adverse	JJ
cord-006229-7yoilsho	1149	23	effects	effect	NNS
cord-006229-7yoilsho	1149	24	[	[	-LRB-
cord-006229-7yoilsho	1149	25	1	1	CD
cord-006229-7yoilsho	1149	26	]	]	-RRB-
cord-006229-7yoilsho	1149	27	.	.	.
cord-006229-7yoilsho	1150	1	Immunotoxicity	immunotoxicity	NN
cord-006229-7yoilsho	1150	2	can	can	MD
cord-006229-7yoilsho	1150	3	be	be	VB
cord-006229-7yoilsho	1150	4	divided	divide	VBN
cord-006229-7yoilsho	1150	5	into	into	IN
cord-006229-7yoilsho	1150	6	four	four	CD
cord-006229-7yoilsho	1150	7	types	type	NNS
cord-006229-7yoilsho	1150	8	of	of	IN
cord-006229-7yoilsho	1150	9	immune	immune	NN
cord-006229-7yoilsho	1150	10	-	-	HYPH
cord-006229-7yoilsho	1150	11	mediated	mediate	VBN
cord-006229-7yoilsho	1150	12	adverse	adverse	JJ
cord-006229-7yoilsho	1150	13	effects	effect	NNS
cord-006229-7yoilsho	1150	14	:	:	:
cord-006229-7yoilsho	1150	15	immunosuppression	immunosuppression	NN
cord-006229-7yoilsho	1150	16	,	,	,
cord-006229-7yoilsho	1150	17	immunostimulation	immunostimulation	NN
cord-006229-7yoilsho	1150	18	,	,	,
cord-006229-7yoilsho	1150	19	hypersensitivity	hypersensitivity	NN
cord-006229-7yoilsho	1150	20	and	and	CC
cord-006229-7yoilsho	1150	21	autoimmunity	autoimmunity	NN
cord-006229-7yoilsho	1150	22	.	.	.
cord-006229-7yoilsho	1151	1	Current	current	JJ
cord-006229-7yoilsho	1151	2	safety	safety	NN
cord-006229-7yoilsho	1151	3	evaluations	evaluation	NNS
cord-006229-7yoilsho	1151	4	of	of	IN
cord-006229-7yoilsho	1151	5	drug	drug	NN
cord-006229-7yoilsho	1151	6	candidates	candidate	NNS
cord-006229-7yoilsho	1151	7	with	with	IN
cord-006229-7yoilsho	1151	8	respect	respect	NN
cord-006229-7yoilsho	1151	9	to	to	IN
cord-006229-7yoilsho	1151	10	immunotoxicity	immunotoxicity	NN
cord-006229-7yoilsho	1151	11	are	be	VBP
cord-006229-7yoilsho	1151	12	comprised	comprise	VBN
cord-006229-7yoilsho	1151	13	of	of	IN
cord-006229-7yoilsho	1151	14	in	in	IN
cord-006229-7yoilsho	1151	15	vivo	vivo	NN
cord-006229-7yoilsho	1151	16	and	and	CC
cord-006229-7yoilsho	1151	17	in	in	IN
cord-006229-7yoilsho	1151	18	vitro	vitro	FW
cord-006229-7yoilsho	1151	19	assays	assay	NNS
cord-006229-7yoilsho	1151	20	.	.	.
cord-006229-7yoilsho	1152	1	Here	here	RB
cord-006229-7yoilsho	1152	2	,	,	,
cord-006229-7yoilsho	1152	3	we	-PRON-	PRP
cord-006229-7yoilsho	1152	4	present	present	VBP
cord-006229-7yoilsho	1152	5	an	an	DT
cord-006229-7yoilsho	1152	6	in	in	IN
cord-006229-7yoilsho	1152	7	silico	silico	NN
cord-006229-7yoilsho	1152	8	approach	approach	NN
cord-006229-7yoilsho	1152	9	for	for	IN
cord-006229-7yoilsho	1152	10	predicting	predict	VBG
cord-006229-7yoilsho	1152	11	immunotoxic	immunotoxic	JJ
cord-006229-7yoilsho	1152	12	substances	substance	NNS
cord-006229-7yoilsho	1152	13	based	base	VBN
cord-006229-7yoilsho	1152	14	on	on	IN
cord-006229-7yoilsho	1152	15	immune	immune	JJ
cord-006229-7yoilsho	1152	16	suppressive	suppressive	JJ
cord-006229-7yoilsho	1152	17	and	and	CC
cord-006229-7yoilsho	1152	18	not	not	RB
cord-006229-7yoilsho	1152	19	toxic	toxic	JJ
cord-006229-7yoilsho	1152	20	compounds	compound	NNS
cord-006229-7yoilsho	1152	21	using	use	VBG
cord-006229-7yoilsho	1152	22	the	the	DT
cord-006229-7yoilsho	1152	23	Laplacian	Laplacian	NNP
cord-006229-7yoilsho	1152	24	-	-	HYPH
cord-006229-7yoilsho	1152	25	modified	modify	VBN
cord-006229-7yoilsho	1152	26	naϊve	naϊve	NNP
cord-006229-7yoilsho	1152	27	Baysian	Baysian	NNP
cord-006229-7yoilsho	1152	28	model	model	NN
cord-006229-7yoilsho	1152	29	as	as	IN
cord-006229-7yoilsho	1152	30	a	a	DT
cord-006229-7yoilsho	1152	31	supervised	supervise	VBN
cord-006229-7yoilsho	1152	32	machine	machine	NN
cord-006229-7yoilsho	1152	33	learning	learning	NN
cord-006229-7yoilsho	1152	34	method	method	NN
cord-006229-7yoilsho	1152	35	.	.	.
cord-006229-7yoilsho	1153	1	Therefore	therefore	RB
cord-006229-7yoilsho	1153	2	,	,	,
cord-006229-7yoilsho	1153	3	we	-PRON-	PRP
cord-006229-7yoilsho	1153	4	examined	examine	VBD
cord-006229-7yoilsho	1153	5	the	the	DT
cord-006229-7yoilsho	1153	6	relations	relation	NNS
cord-006229-7yoilsho	1153	7	between	between	IN
cord-006229-7yoilsho	1153	8	about	about	RB
cord-006229-7yoilsho	1153	9	51,000	51,000	CD
cord-006229-7yoilsho	1153	10	compounds	compound	NNS
cord-006229-7yoilsho	1153	11	and	and	CC
cord-006229-7yoilsho	1153	12	115	115	CD
cord-006229-7yoilsho	1153	13	cancer	cancer	NN
cord-006229-7yoilsho	1153	14	cell	cell	NN
cord-006229-7yoilsho	1153	15	lines	line	NNS
cord-006229-7yoilsho	1153	16	from	from	IN
cord-006229-7yoilsho	1153	17	the	the	DT
cord-006229-7yoilsho	1153	18	National	National	NNP
cord-006229-7yoilsho	1153	19	Cancer	Cancer	NNP
cord-006229-7yoilsho	1153	20	Institute	Institute	NNP
cord-006229-7yoilsho	1153	21	's	's	POS
cord-006229-7yoilsho	1153	22	(	(	-LRB-
cord-006229-7yoilsho	1153	23	NCI	NCI	NNP
cord-006229-7yoilsho	1153	24	)	)	-RRB-
cord-006229-7yoilsho	1153	25	NCI-60	nci-60	CD
cord-006229-7yoilsho	1153	26	growth	growth	NN
cord-006229-7yoilsho	1153	27	inhibition	inhibition	NN
cord-006229-7yoilsho	1153	28	data	datum	NNS
cord-006229-7yoilsho	1153	29	[	[	-LRB-
cord-006229-7yoilsho	1153	30	2	2	CD
cord-006229-7yoilsho	1153	31	]	]	-RRB-
cord-006229-7yoilsho	1154	1	with	with	IN
cord-006229-7yoilsho	1154	2	focus	focus	NN
cord-006229-7yoilsho	1154	3	on	on	IN
cord-006229-7yoilsho	1154	4	five	five	CD
cord-006229-7yoilsho	1154	5	immune	immune	JJ
cord-006229-7yoilsho	1154	6	cell	cell	NN
cord-006229-7yoilsho	1154	7	lines	line	NNS
cord-006229-7yoilsho	1154	8	(	(	-LRB-
cord-006229-7yoilsho	1154	9	RPMI-8226	RPMI-8226	NNP
cord-006229-7yoilsho	1154	10	,	,	,
cord-006229-7yoilsho	1154	11	CCRF	CCRF	NNP
cord-006229-7yoilsho	1154	12	-	-	HYPH
cord-006229-7yoilsho	1154	13	CEM	CEM	NNP
cord-006229-7yoilsho	1154	14	,	,	,
cord-006229-7yoilsho	1154	15	.	.	.
cord-006229-7yoilsho	1155	1	Different	different	JJ
cord-006229-7yoilsho	1155	2	fingerprints	fingerprint	NNS
cord-006229-7yoilsho	1155	3	encoding	encode	VBG
cord-006229-7yoilsho	1155	4	the	the	DT
cord-006229-7yoilsho	1155	5	chemical	chemical	JJ
cord-006229-7yoilsho	1155	6	structures	structure	NNS
cord-006229-7yoilsho	1155	7	have	have	VBP
cord-006229-7yoilsho	1155	8	been	be	VBN
cord-006229-7yoilsho	1155	9	evaluated	evaluate	VBN
cord-006229-7yoilsho	1155	10	for	for	IN
cord-006229-7yoilsho	1155	11	their	-PRON-	PRP$
cord-006229-7yoilsho	1155	12	predictive	predictive	JJ
cord-006229-7yoilsho	1155	13	power	power	NN
cord-006229-7yoilsho	1155	14	(	(	-LRB-
cord-006229-7yoilsho	1155	15	e.	e.	NNP
cord-006229-7yoilsho	1155	16	g.	g.	NNP
cord-006229-7yoilsho	1155	17	Extended	Extended	NNP
cord-006229-7yoilsho	1155	18	-	-	HYPH
cord-006229-7yoilsho	1155	19	connectivity	connectivity	NN
cord-006229-7yoilsho	1155	20	fingerprints	fingerprint	NNS
cord-006229-7yoilsho	1155	21	,	,	,
cord-006229-7yoilsho	1155	22	substructure	substructure	NN
cord-006229-7yoilsho	1155	23	fingerprints	fingerprint	NNS
cord-006229-7yoilsho	1155	24	)	)	-RRB-
cord-006229-7yoilsho	1155	25	and	and	CC
cord-006229-7yoilsho	1155	26	showed	show	VBD
cord-006229-7yoilsho	1155	27	good	good	JJ
cord-006229-7yoilsho	1155	28	prediction	prediction	NN
cord-006229-7yoilsho	1155	29	rates	rate	NNS
cord-006229-7yoilsho	1155	30	in	in	IN
cord-006229-7yoilsho	1155	31	a	a	DT
cord-006229-7yoilsho	1155	32	retrospective	retrospective	JJ
cord-006229-7yoilsho	1155	33	analysis	analysis	NN
cord-006229-7yoilsho	1155	34	.	.	.
cord-006229-7yoilsho	1156	1	Acting	act	VBG
cord-006229-7yoilsho	1156	2	in	in	IN
cord-006229-7yoilsho	1156	3	phase	phase	NN
cord-006229-7yoilsho	1156	4	II	ii	CD
cord-006229-7yoilsho	1156	5	metabolism	metabolism	NN
cord-006229-7yoilsho	1156	6	,	,	,
cord-006229-7yoilsho	1156	7	sulfotransferases	sulfotransferase	NNS
cord-006229-7yoilsho	1156	8	(	(	-LRB-
cord-006229-7yoilsho	1156	9	SULT	SULT	NNP
cord-006229-7yoilsho	1156	10	)	)	-RRB-
cord-006229-7yoilsho	1156	11	transform	transform	VB
cord-006229-7yoilsho	1156	12	endo	endo	NN
cord-006229-7yoilsho	1156	13	-	-	HYPH
cord-006229-7yoilsho	1156	14	and	and	CC
cord-006229-7yoilsho	1156	15	exogenous	exogenous	JJ
cord-006229-7yoilsho	1156	16	molecules	molecule	NNS
cord-006229-7yoilsho	1156	17	such	such	JJ
cord-006229-7yoilsho	1156	18	as	as	IN
cord-006229-7yoilsho	1156	19	drugs	drug	NNS
cord-006229-7yoilsho	1156	20	into	into	IN
cord-006229-7yoilsho	1156	21	more	more	JJR
cord-006229-7yoilsho	1156	22	hydrophilic	hydrophilic	JJ
cord-006229-7yoilsho	1156	23	entities	entity	NNS
cord-006229-7yoilsho	1156	24	that	that	WDT
cord-006229-7yoilsho	1156	25	are	be	VBP
cord-006229-7yoilsho	1156	26	easily	easily	RB
cord-006229-7yoilsho	1156	27	excreted	excrete	VBN
cord-006229-7yoilsho	1156	28	from	from	IN
cord-006229-7yoilsho	1156	29	the	the	DT
cord-006229-7yoilsho	1156	30	human	human	JJ
cord-006229-7yoilsho	1156	31	body	body	NN
cord-006229-7yoilsho	1156	32	[	[	-LRB-
cord-006229-7yoilsho	1156	33	1	1	CD
cord-006229-7yoilsho	1156	34	]	]	-RRB-
cord-006229-7yoilsho	1156	35	.	.	.
cord-006229-7yoilsho	1157	1	Although	although	IN
cord-006229-7yoilsho	1157	2	serving	serve	VBG
cord-006229-7yoilsho	1157	3	detoxification	detoxification	NN
cord-006229-7yoilsho	1157	4	,	,	,
cord-006229-7yoilsho	1157	5	SULT	sult	NN
cord-006229-7yoilsho	1157	6	-	-	HYPH
cord-006229-7yoilsho	1157	7	mediated	mediate	VBN
cord-006229-7yoilsho	1157	8	transformation	transformation	NN
cord-006229-7yoilsho	1157	9	of	of	IN
cord-006229-7yoilsho	1157	10	molecules	molecule	NNS
cord-006229-7yoilsho	1157	11	has	have	VBZ
cord-006229-7yoilsho	1157	12	also	also	RB
cord-006229-7yoilsho	1157	13	been	be	VBN
cord-006229-7yoilsho	1157	14	associated	associate	VBN
cord-006229-7yoilsho	1157	15	with	with	IN
cord-006229-7yoilsho	1157	16	the	the	DT
cord-006229-7yoilsho	1157	17	formation	formation	NN
cord-006229-7yoilsho	1157	18	of	of	IN
cord-006229-7yoilsho	1157	19	chemically	chemically	RB
cord-006229-7yoilsho	1157	20	reactive	reactive	JJ
cord-006229-7yoilsho	1157	21	metabolites	metabolite	NNS
cord-006229-7yoilsho	1157	22	that	that	WDT
cord-006229-7yoilsho	1157	23	could	could	MD
cord-006229-7yoilsho	1157	24	promote	promote	VB
cord-006229-7yoilsho	1157	25	adverse	adverse	JJ
cord-006229-7yoilsho	1157	26	reactions	reaction	NNS
cord-006229-7yoilsho	1157	27	[	[	-LRB-
cord-006229-7yoilsho	1157	28	2	2	CD
cord-006229-7yoilsho	1157	29	]	]	-RRB-
cord-006229-7yoilsho	1157	30	.	.	.
cord-006229-7yoilsho	1158	1	The	the	DT
cord-006229-7yoilsho	1158	2	development	development	NN
cord-006229-7yoilsho	1158	3	of	of	IN
cord-006229-7yoilsho	1158	4	a	a	DT
cord-006229-7yoilsho	1158	5	computerbased	computerbased	JJ
cord-006229-7yoilsho	1158	6	model	model	NN
cord-006229-7yoilsho	1158	7	that	that	WDT
cord-006229-7yoilsho	1158	8	allows	allow	VBZ
cord-006229-7yoilsho	1158	9	prediction	prediction	NN
cord-006229-7yoilsho	1158	10	of	of	IN
cord-006229-7yoilsho	1158	11	molecules	molecule	NNS
cord-006229-7yoilsho	1158	12	susceptible	susceptible	JJ
cord-006229-7yoilsho	1158	13	to	to	IN
cord-006229-7yoilsho	1158	14	metabolism	metabolism	NN
cord-006229-7yoilsho	1158	15	would	would	MD
cord-006229-7yoilsho	1158	16	improve	improve	VB
cord-006229-7yoilsho	1158	17	drug	drug	NN
cord-006229-7yoilsho	1158	18	development	development	NN
cord-006229-7yoilsho	1158	19	and	and	CC
cord-006229-7yoilsho	1158	20	drug	drug	NN
cord-006229-7yoilsho	1158	21	safety	safety	NN
cord-006229-7yoilsho	1158	22	[	[	-LRB-
cord-006229-7yoilsho	1158	23	3	3	CD
cord-006229-7yoilsho	1158	24	]	]	-RRB-
cord-006229-7yoilsho	1158	25	,	,	,
cord-006229-7yoilsho	1158	26	and	and	CC
cord-006229-7yoilsho	1158	27	encourage	encourage	VB
cord-006229-7yoilsho	1158	28	the	the	DT
cord-006229-7yoilsho	1158	29	reduction	reduction	NN
cord-006229-7yoilsho	1158	30	of	of	IN
cord-006229-7yoilsho	1158	31	in	in	IN
cord-006229-7yoilsho	1158	32	vivo	vivo	FW
cord-006229-7yoilsho	1158	33	testing	testing	NN
cord-006229-7yoilsho	1158	34	according	accord	VBG
cord-006229-7yoilsho	1158	35	to	to	IN
cord-006229-7yoilsho	1158	36	the	the	DT
cord-006229-7yoilsho	1158	37	principles	principle	NNS
cord-006229-7yoilsho	1158	38	of	of	IN
cord-006229-7yoilsho	1158	39	the	the	DT
cord-006229-7yoilsho	1158	40	3Rs	3rs	NN
cord-006229-7yoilsho	1158	41	(	(	-LRB-
cord-006229-7yoilsho	1158	42	Replacement	replacement	NN
cord-006229-7yoilsho	1158	43	,	,	,
cord-006229-7yoilsho	1158	44	Reduction	Reduction	NNP
cord-006229-7yoilsho	1158	45	and	and	CC
cord-006229-7yoilsho	1158	46	Refinement	Refinement	NNP
cord-006229-7yoilsho	1158	47	)	)	-RRB-
cord-006229-7yoilsho	1158	48	.	.	.
cord-006229-7yoilsho	1159	1	In	in	IN
cord-006229-7yoilsho	1159	2	our	-PRON-	PRP$
cord-006229-7yoilsho	1159	3	study	study	NN
cord-006229-7yoilsho	1159	4	,	,	,
cord-006229-7yoilsho	1159	5	we	-PRON-	PRP
cord-006229-7yoilsho	1159	6	developed	develop	VBD
cord-006229-7yoilsho	1159	7	an	an	DT
cord-006229-7yoilsho	1159	8	in	in	IN
cord-006229-7yoilsho	1159	9	silico	silico	NN
cord-006229-7yoilsho	1159	10	model	model	NN
cord-006229-7yoilsho	1159	11	to	to	TO
cord-006229-7yoilsho	1159	12	predict	predict	VB
cord-006229-7yoilsho	1159	13	human	human	JJ
cord-006229-7yoilsho	1159	14	SULT	SULT	NNP
cord-006229-7yoilsho	1159	15	subtype	subtype	NN
cord-006229-7yoilsho	1159	16	1E1	1e1	CD
cord-006229-7yoilsho	1159	17	activity	activity	NN
cord-006229-7yoilsho	1159	18	acting	act	VBG
cord-006229-7yoilsho	1159	19	in	in	IN
cord-006229-7yoilsho	1159	20	phase	phase	NN
cord-006229-7yoilsho	1159	21	II	ii	CD
cord-006229-7yoilsho	1159	22	metabolism	metabolism	NN
cord-006229-7yoilsho	1159	23	.	.	.
cord-006229-7yoilsho	1160	1	Structure	structure	NN
cord-006229-7yoilsho	1160	2	-	-	HYPH
cord-006229-7yoilsho	1160	3	based	base	VBN
cord-006229-7yoilsho	1160	4	molecular	molecular	JJ
cord-006229-7yoilsho	1160	5	modelling	modelling	NN
cord-006229-7yoilsho	1160	6	of	of	IN
cord-006229-7yoilsho	1160	7	SULT	sult	NN
cord-006229-7yoilsho	1160	8	activity	activity	NN
cord-006229-7yoilsho	1160	9	is	be	VBZ
cord-006229-7yoilsho	1160	10	challenging	challenge	VBG
cord-006229-7yoilsho	1160	11	due	due	IN
cord-006229-7yoilsho	1160	12	to	to	IN
cord-006229-7yoilsho	1160	13	the	the	DT
cord-006229-7yoilsho	1160	14	broad	broad	JJ
cord-006229-7yoilsho	1160	15	and	and	CC
cord-006229-7yoilsho	1160	16	overlapping	overlap	VBG
cord-006229-7yoilsho	1160	17	substrate	substrate	NN
cord-006229-7yoilsho	1160	18	spectrum	spectrum	NN
cord-006229-7yoilsho	1160	19	of	of	IN
cord-006229-7yoilsho	1160	20	SULT	SULT	NNP
cord-006229-7yoilsho	1160	21	subtypes	subtype	NNS
cord-006229-7yoilsho	1160	22	.	.	.
cord-006229-7yoilsho	1161	1	This	this	DT
cord-006229-7yoilsho	1161	2	low	low	JJ
cord-006229-7yoilsho	1161	3	substrate	substrate	NN
cord-006229-7yoilsho	1161	4	specificity	specificity	NN
cord-006229-7yoilsho	1161	5	can	can	MD
cord-006229-7yoilsho	1161	6	be	be	VB
cord-006229-7yoilsho	1161	7	attributed	attribute	VBN
cord-006229-7yoilsho	1161	8	to	to	IN
cord-006229-7yoilsho	1161	9	the	the	DT
cord-006229-7yoilsho	1161	10	high	high	JJ
cord-006229-7yoilsho	1161	11	degree	degree	NN
cord-006229-7yoilsho	1161	12	of	of	IN
cord-006229-7yoilsho	1161	13	conformational	conformational	JJ
cord-006229-7yoilsho	1161	14	flexibility	flexibility	NN
cord-006229-7yoilsho	1161	15	of	of	IN
cord-006229-7yoilsho	1161	16	the	the	DT
cord-006229-7yoilsho	1161	17	enzyme	enzyme	NN
cord-006229-7yoilsho	1161	18	,	,	,
cord-006229-7yoilsho	1161	19	particularly	particularly	RB
cord-006229-7yoilsho	1161	20	in	in	IN
cord-006229-7yoilsho	1161	21	the	the	DT
cord-006229-7yoilsho	1161	22	active	active	JJ
cord-006229-7yoilsho	1161	23	site	site	NN
cord-006229-7yoilsho	1161	24	.	.	.
cord-006229-7yoilsho	1162	1	Therefore	therefore	RB
cord-006229-7yoilsho	1162	2	,	,	,
cord-006229-7yoilsho	1162	3	molecular	molecular	JJ
cord-006229-7yoilsho	1162	4	dynamics	dynamic	NNS
cord-006229-7yoilsho	1162	5	simulations	simulation	NNS
cord-006229-7yoilsho	1162	6	were	be	VBD
cord-006229-7yoilsho	1162	7	performed	perform	VBN
cord-006229-7yoilsho	1162	8	to	to	TO
cord-006229-7yoilsho	1162	9	address	address	VB
cord-006229-7yoilsho	1162	10	enzyme	enzyme	NN
cord-006229-7yoilsho	1162	11	flexibility	flexibility	NN
cord-006229-7yoilsho	1162	12	and	and	CC
cord-006229-7yoilsho	1162	13	the	the	DT
cord-006229-7yoilsho	1162	14	broad	broad	JJ
cord-006229-7yoilsho	1162	15	substrate	substrate	NN
cord-006229-7yoilsho	1162	16	spectrum	spectrum	NN
cord-006229-7yoilsho	1162	17	of	of	IN
cord-006229-7yoilsho	1162	18	SULT	SULT	NNP
cord-006229-7yoilsho	1162	19	(	(	-LRB-
cord-006229-7yoilsho	1162	20	Figure	figure	NN
cord-006229-7yoilsho	1162	21	1	1	CD
cord-006229-7yoilsho	1162	22	)	)	-RRB-
cord-006229-7yoilsho	1162	23	.	.	.
cord-006229-7yoilsho	1163	1	Based	base	VBN
cord-006229-7yoilsho	1163	2	on	on	IN
cord-006229-7yoilsho	1163	3	a	a	DT
cord-006229-7yoilsho	1163	4	collection	collection	NN
cord-006229-7yoilsho	1163	5	of	of	IN
cord-006229-7yoilsho	1163	6	selected	select	VBN
cord-006229-7yoilsho	1163	7	enzyme	enzyme	NN
cord-006229-7yoilsho	1163	8	conformations	conformation	NNS
cord-006229-7yoilsho	1163	9	from	from	IN
cord-006229-7yoilsho	1163	10	molecular	molecular	JJ
cord-006229-7yoilsho	1163	11	dynamics	dynamic	NNS
cord-006229-7yoilsho	1163	12	simulations	simulation	NNS
cord-006229-7yoilsho	1163	13	and	and	CC
cord-006229-7yoilsho	1163	14	a	a	DT
cord-006229-7yoilsho	1163	15	dataset	dataset	NN
cord-006229-7yoilsho	1163	16	of	of	IN
cord-006229-7yoilsho	1163	17	active	active	JJ
cord-006229-7yoilsho	1163	18	SULT1E1	SULT1E1	NNP
cord-006229-7yoilsho	1163	19	ligands	ligand	NNS
cord-006229-7yoilsho	1163	20	,	,	,
cord-006229-7yoilsho	1163	21	ensemble	ensemble	JJ
cord-006229-7yoilsho	1163	22	docking	docking	NN
cord-006229-7yoilsho	1163	23	was	be	VBD
cord-006229-7yoilsho	1163	24	utilized	utilize	VBN
cord-006229-7yoilsho	1163	25	to	to	TO
cord-006229-7yoilsho	1163	26	generate	generate	VB
cord-006229-7yoilsho	1163	27	ligand	ligand	NN
cord-006229-7yoilsho	1163	28	-	-	HYPH
cord-006229-7yoilsho	1163	29	protein	protein	NN
cord-006229-7yoilsho	1163	30	complexes	complex	NNS
cord-006229-7yoilsho	1163	31	that	that	WDT
cord-006229-7yoilsho	1163	32	served	serve	VBD
cord-006229-7yoilsho	1163	33	as	as	IN
cord-006229-7yoilsho	1163	34	a	a	DT
cord-006229-7yoilsho	1163	35	basis	basis	NN
cord-006229-7yoilsho	1163	36	for	for	IN
cord-006229-7yoilsho	1163	37	3D	3D	NNP
cord-006229-7yoilsho	1163	38	pharmacophore	pharmacophore	NNP
cord-006229-7yoilsho	1163	39	development	development	NNP
cord-006229-7yoilsho	1163	40	.	.	.
cord-006229-7yoilsho	1164	1	Eight	eight	CD
cord-006229-7yoilsho	1164	2	specific	specific	JJ
cord-006229-7yoilsho	1164	3	3D	3d	JJ
cord-006229-7yoilsho	1164	4	pharmacophores	pharmacophore	NNS
cord-006229-7yoilsho	1164	5	were	be	VBD
cord-006229-7yoilsho	1164	6	created	create	VBN
cord-006229-7yoilsho	1164	7	that	that	WDT
cord-006229-7yoilsho	1164	8	allow	allow	VB
cord-006229-7yoilsho	1164	9	identification	identification	NN
cord-006229-7yoilsho	1164	10	of	of	IN
cord-006229-7yoilsho	1164	11	SULT1E1	SULT1E1	NNP
cord-006229-7yoilsho	1164	12	substrates	substrate	NNS
cord-006229-7yoilsho	1164	13	and	and	CC
cord-006229-7yoilsho	1164	14	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	1164	15	.	.	.
cord-006229-7yoilsho	1165	1	For	for	IN
cord-006229-7yoilsho	1165	2	further	further	JJ
cord-006229-7yoilsho	1165	3	refinement	refinement	NN
cord-006229-7yoilsho	1165	4	of	of	IN
cord-006229-7yoilsho	1165	5	the	the	DT
cord-006229-7yoilsho	1165	6	computer	computer	NN
cord-006229-7yoilsho	1165	7	-	-	HYPH
cord-006229-7yoilsho	1165	8	based	base	VBN
cord-006229-7yoilsho	1165	9	prediction	prediction	NN
cord-006229-7yoilsho	1165	10	,	,	,
cord-006229-7yoilsho	1165	11	machine	machine	NN
cord-006229-7yoilsho	1165	12	learning	learning	NN
cord-006229-7yoilsho	1165	13	models	model	NNS
cord-006229-7yoilsho	1165	14	and	and	CC
cord-006229-7yoilsho	1165	15	post	post	JJ
cord-006229-7yoilsho	1165	16	-	-	JJ
cord-006229-7yoilsho	1165	17	filtering	filtering	JJ
cord-006229-7yoilsho	1165	18	steps	step	NNS
cord-006229-7yoilsho	1165	19	were	be	VBD
cord-006229-7yoilsho	1165	20	generated	generate	VBN
cord-006229-7yoilsho	1165	21	that	that	WDT
cord-006229-7yoilsho	1165	22	allow	allow	VBP
cord-006229-7yoilsho	1165	23	classification	classification	NN
cord-006229-7yoilsho	1165	24	of	of	IN
cord-006229-7yoilsho	1165	25	predicted	predict	VBN
cord-006229-7yoilsho	1165	26	hits	hit	NNS
cord-006229-7yoilsho	1165	27	.	.	.
cord-006229-7yoilsho	1166	1	The	the	DT
cord-006229-7yoilsho	1166	2	final	final	JJ
cord-006229-7yoilsho	1166	3	prediction	prediction	NN
cord-006229-7yoilsho	1166	4	model	model	NN
cord-006229-7yoilsho	1166	5	was	be	VBD
cord-006229-7yoilsho	1166	6	used	use	VBN
cord-006229-7yoilsho	1166	7	to	to	TO
cord-006229-7yoilsho	1166	8	screen	screen	VB
cord-006229-7yoilsho	1166	9	the	the	DT
cord-006229-7yoilsho	1166	10	DrugBank	DrugBank	NNP
cord-006229-7yoilsho	1166	11	(	(	-LRB-
cord-006229-7yoilsho	1166	12	a	a	DT
cord-006229-7yoilsho	1166	13	database	database	NN
cord-006229-7yoilsho	1166	14	comprising	comprise	VBG
cord-006229-7yoilsho	1166	15	over	over	IN
cord-006229-7yoilsho	1166	16	6,500	6,500	CD
cord-006229-7yoilsho	1166	17	experimental	experimental	JJ
cord-006229-7yoilsho	1166	18	and	and	CC
cord-006229-7yoilsho	1166	19	approved	approve	VBD
cord-006229-7yoilsho	1166	20	drugs	drug	NNS
cord-006229-7yoilsho	1166	21	)	)	-RRB-
cord-006229-7yoilsho	1166	22	.	.	.
cord-006229-7yoilsho	1167	1	A	a	DT
cord-006229-7yoilsho	1167	2	major	major	JJ
cord-006229-7yoilsho	1167	3	part	part	NN
cord-006229-7yoilsho	1167	4	of	of	IN
cord-006229-7yoilsho	1167	5	the	the	DT
cord-006229-7yoilsho	1167	6	predicted	predict	VBN
cord-006229-7yoilsho	1167	7	hits	hit	NNS
cord-006229-7yoilsho	1167	8	could	could	MD
cord-006229-7yoilsho	1167	9	be	be	VB
cord-006229-7yoilsho	1167	10	confirmed	confirm	VBN
cord-006229-7yoilsho	1167	11	from	from	IN
cord-006229-7yoilsho	1167	12	literature	literature	NN
cord-006229-7yoilsho	1167	13	.	.	.
cord-006229-7yoilsho	1168	1	From	from	IN
cord-006229-7yoilsho	1168	2	the	the	DT
cord-006229-7yoilsho	1168	3	remaining	remain	VBG
cord-006229-7yoilsho	1168	4	hits	hit	NNS
cord-006229-7yoilsho	1168	5	,	,	,
cord-006229-7yoilsho	1168	6	a	a	DT
cord-006229-7yoilsho	1168	7	representative	representative	JJ
cord-006229-7yoilsho	1168	8	selection	selection	NN
cord-006229-7yoilsho	1168	9	of	of	IN
cord-006229-7yoilsho	1168	10	molecules	molecule	NNS
cord-006229-7yoilsho	1168	11	was	be	VBD
cord-006229-7yoilsho	1168	12	experimentally	experimentally	RB
cord-006229-7yoilsho	1168	13	tested	test	VBN
cord-006229-7yoilsho	1168	14	for	for	IN
cord-006229-7yoilsho	1168	15	SULT1E1	SULT1E1	NNP
cord-006229-7yoilsho	1168	16	inhibition	inhibition	NN
cord-006229-7yoilsho	1168	17	or	or	CC
cord-006229-7yoilsho	1168	18	biotransformation	biotransformation	NN
cord-006229-7yoilsho	1168	19	.	.	.
cord-006229-7yoilsho	1169	1	Experimental	experimental	JJ
cord-006229-7yoilsho	1169	2	results	result	NNS
cord-006229-7yoilsho	1169	3	were	be	VBD
cord-006229-7yoilsho	1169	4	in	in	IN
cord-006229-7yoilsho	1169	5	agreement	agreement	NN
cord-006229-7yoilsho	1169	6	with	with	IN
cord-006229-7yoilsho	1169	7	our	-PRON-	PRP$
cord-006229-7yoilsho	1169	8	computer	computer	NN
cord-006229-7yoilsho	1169	9	-	-	HYPH
cord-006229-7yoilsho	1169	10	based	base	VBN
cord-006229-7yoilsho	1169	11	models	model	NNS
cord-006229-7yoilsho	1169	12	and	and	CC
cord-006229-7yoilsho	1169	13	revealed	reveal	VBD
cord-006229-7yoilsho	1169	14	previously	previously	RB
cord-006229-7yoilsho	1169	15	-	-	HYPH
cord-006229-7yoilsho	1169	16	unknown	unknown	JJ
cord-006229-7yoilsho	1169	17	biotransformation	biotransformation	NN
cord-006229-7yoilsho	1169	18	by	by	IN
cord-006229-7yoilsho	1169	19	or	or	CC
cord-006229-7yoilsho	1169	20	inhibition	inhibition	NN
cord-006229-7yoilsho	1169	21	of	of	IN
cord-006229-7yoilsho	1169	22	SULT1E1	SULT1E1	NNP
cord-006229-7yoilsho	1169	23	for	for	IN
cord-006229-7yoilsho	1169	24	compounds	compound	NNS
cord-006229-7yoilsho	1169	25	listed	list	VBN
cord-006229-7yoilsho	1169	26	in	in	IN
cord-006229-7yoilsho	1169	27	the	the	DT
cord-006229-7yoilsho	1169	28	DrugBank	DrugBank	NNP
cord-006229-7yoilsho	1169	29	.	.	.
cord-006229-7yoilsho	1170	1	Introduction	introduction	NN
cord-006229-7yoilsho	1170	2	:	:	:
cord-006229-7yoilsho	1171	1	Vascularization	vascularization	NN
cord-006229-7yoilsho	1171	2	of	of	IN
cord-006229-7yoilsho	1171	3	the	the	DT
cord-006229-7yoilsho	1171	4	dermal	dermal	JJ
cord-006229-7yoilsho	1171	5	equivalent	equivalent	NN
cord-006229-7yoilsho	1171	6	of	of	IN
cord-006229-7yoilsho	1171	7	full	full	JJ
cord-006229-7yoilsho	1171	8	-	-	HYPH
cord-006229-7yoilsho	1171	9	thickness	thickness	NN
cord-006229-7yoilsho	1171	10	skin	skin	NN
cord-006229-7yoilsho	1171	11	constructs	construct	NNS
cord-006229-7yoilsho	1171	12	by	by	IN
cord-006229-7yoilsho	1171	13	endothelial	endothelial	JJ
cord-006229-7yoilsho	1171	14	cells	cell	NNS
cord-006229-7yoilsho	1171	15	is	be	VBZ
cord-006229-7yoilsho	1171	16	highly	highly	RB
cord-006229-7yoilsho	1171	17	desirable	desirable	JJ
cord-006229-7yoilsho	1171	18	,	,	,
cord-006229-7yoilsho	1171	19	because	because	IN
cord-006229-7yoilsho	1171	20	such	such	JJ
cord-006229-7yoilsho	1171	21	constructs	construct	NNS
cord-006229-7yoilsho	1171	22	closely	closely	RB
cord-006229-7yoilsho	1171	23	mimic	mimic	VBP
cord-006229-7yoilsho	1171	24	the	the	DT
cord-006229-7yoilsho	1171	25	architecture	architecture	NN
cord-006229-7yoilsho	1171	26	of	of	IN
cord-006229-7yoilsho	1171	27	real	real	JJ
cord-006229-7yoilsho	1171	28	skin	skin	NN
cord-006229-7yoilsho	1171	29	.	.	.
cord-006229-7yoilsho	1172	1	Unfortunately	unfortunately	RB
cord-006229-7yoilsho	1172	2	,	,	,
cord-006229-7yoilsho	1172	3	the	the	DT
cord-006229-7yoilsho	1172	4	realization	realization	NN
cord-006229-7yoilsho	1172	5	of	of	IN
cord-006229-7yoilsho	1172	6	a	a	DT
cord-006229-7yoilsho	1172	7	capillary	capillary	JJ
cord-006229-7yoilsho	1172	8	network	network	NN
cord-006229-7yoilsho	1172	9	in	in	IN
cord-006229-7yoilsho	1172	10	skin	skin	NN
cord-006229-7yoilsho	1172	11	constructs	construct	NNS
cord-006229-7yoilsho	1172	12	is	be	VBZ
cord-006229-7yoilsho	1172	13	still	still	RB
cord-006229-7yoilsho	1172	14	difficult	difficult	JJ
cord-006229-7yoilsho	1172	15	.	.	.
cord-006229-7yoilsho	1173	1	In	in	IN
cord-006229-7yoilsho	1173	2	our	-PRON-	PRP$
cord-006229-7yoilsho	1173	3	study	study	NN
cord-006229-7yoilsho	1173	4	of	of	IN
cord-006229-7yoilsho	1173	5	full	full	JJ
cord-006229-7yoilsho	1173	6	-	-	HYPH
cord-006229-7yoilsho	1173	7	thickness	thickness	NN
cord-006229-7yoilsho	1173	8	skin	skin	NN
cord-006229-7yoilsho	1173	9	constructs	construct	NNS
cord-006229-7yoilsho	1173	10	,	,	,
cord-006229-7yoilsho	1173	11	following	follow	VBG
cord-006229-7yoilsho	1173	12	the	the	DT
cord-006229-7yoilsho	1173	13	methodologies	methodology	NNS
cord-006229-7yoilsho	1173	14	of	of	IN
cord-006229-7yoilsho	1173	15	Küchler	Küchler	NNP
cord-006229-7yoilsho	1173	16	et	et	NNP
cord-006229-7yoilsho	1173	17	al	al	NNP
cord-006229-7yoilsho	1173	18	.	.	.
cord-006229-7yoilsho	1174	1	(	(	-LRB-
cord-006229-7yoilsho	1174	2	2011	2011	CD
cord-006229-7yoilsho	1174	3	)	)	-RRB-
cord-006229-7yoilsho	1174	4	,	,	,
cord-006229-7yoilsho	1174	5	there	there	EX
cord-006229-7yoilsho	1174	6	were	be	VBD
cord-006229-7yoilsho	1174	7	alterations	alteration	NNS
cord-006229-7yoilsho	1174	8	in	in	IN
cord-006229-7yoilsho	1174	9	the	the	DT
cord-006229-7yoilsho	1174	10	epidermal	epidermal	JJ
cord-006229-7yoilsho	1174	11	differentiation	differentiation	NN
cord-006229-7yoilsho	1174	12	after	after	IN
cord-006229-7yoilsho	1174	13	endothelialization	endothelialization	NN
cord-006229-7yoilsho	1174	14	of	of	IN
cord-006229-7yoilsho	1174	15	the	the	DT
cord-006229-7yoilsho	1174	16	dermal	dermal	JJ
cord-006229-7yoilsho	1174	17	equivalent	equivalent	NN
cord-006229-7yoilsho	1174	18	.	.	.
cord-006229-7yoilsho	1175	1	The	the	DT
cord-006229-7yoilsho	1175	2	aim	aim	NN
cord-006229-7yoilsho	1175	3	of	of	IN
cord-006229-7yoilsho	1175	4	this	this	DT
cord-006229-7yoilsho	1175	5	study	study	NN
cord-006229-7yoilsho	1175	6	was	be	VBD
cord-006229-7yoilsho	1175	7	to	to	TO
cord-006229-7yoilsho	1175	8	characterize	characterize	VB
cord-006229-7yoilsho	1175	9	these	these	DT
cord-006229-7yoilsho	1175	10	changes	change	NNS
cord-006229-7yoilsho	1175	11	on	on	IN
cord-006229-7yoilsho	1175	12	a	a	DT
cord-006229-7yoilsho	1175	13	morphological	morphological	JJ
cord-006229-7yoilsho	1175	14	level	level	NN
cord-006229-7yoilsho	1175	15	.	.	.
cord-006229-7yoilsho	1176	1	Material	material	NN
cord-006229-7yoilsho	1176	2	and	and	CC
cord-006229-7yoilsho	1176	3	methods	method	NNS
cord-006229-7yoilsho	1176	4	:	:	:
cord-006229-7yoilsho	1176	5	Non	non	JJ
cord-006229-7yoilsho	1176	6	-	-	JJ
cord-006229-7yoilsho	1176	7	endothelialized	endothelialized	JJ
cord-006229-7yoilsho	1176	8	constructs	construct	NNS
cord-006229-7yoilsho	1176	9	(	(	-LRB-
cord-006229-7yoilsho	1176	10	keratinocytes	keratinocyte	NNS
cord-006229-7yoilsho	1176	11	,	,	,
cord-006229-7yoilsho	1176	12	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	1176	13	)	)	-RRB-
cord-006229-7yoilsho	1176	14	were	be	VBD
cord-006229-7yoilsho	1176	15	prepared	prepare	VBN
cord-006229-7yoilsho	1176	16	according	accord	VBG
cord-006229-7yoilsho	1176	17	to	to	IN
cord-006229-7yoilsho	1176	18	Küchler	Küchler	NNP
cord-006229-7yoilsho	1176	19	et	et	NNP
cord-006229-7yoilsho	1176	20	al	al	NNP
cord-006229-7yoilsho	1176	21	.	.	.
cord-006229-7yoilsho	1177	1	(	(	-LRB-
cord-006229-7yoilsho	1177	2	2011	2011	CD
cord-006229-7yoilsho	1177	3	)	)	-RRB-
cord-006229-7yoilsho	1177	4	.	.	.
cord-006229-7yoilsho	1178	1	To	to	TO
cord-006229-7yoilsho	1178	2	obtain	obtain	VB
cord-006229-7yoilsho	1178	3	endothelialized	endothelialized	JJ
cord-006229-7yoilsho	1178	4	constructs	construct	NNS
cord-006229-7yoilsho	1178	5	,	,	,
cord-006229-7yoilsho	1178	6	the	the	DT
cord-006229-7yoilsho	1178	7	dermal	dermal	JJ
cord-006229-7yoilsho	1178	8	equivalent	equivalent	NN
cord-006229-7yoilsho	1178	9	of	of	IN
cord-006229-7yoilsho	1178	10	the	the	DT
cord-006229-7yoilsho	1178	11	non	non	JJ
cord-006229-7yoilsho	1178	12	-	-	JJ
cord-006229-7yoilsho	1178	13	endothelialized	endothelialized	JJ
cord-006229-7yoilsho	1178	14	constructs	construct	NNS
cord-006229-7yoilsho	1178	15	was	be	VBD
cord-006229-7yoilsho	1178	16	enriched	enrich	VBN
cord-006229-7yoilsho	1178	17	with	with	IN
cord-006229-7yoilsho	1178	18	endothelial	endothelial	JJ
cord-006229-7yoilsho	1178	19	cells	cell	NNS
cord-006229-7yoilsho	1178	20	.	.	.
cord-006229-7yoilsho	1179	1	After	after	IN
cord-006229-7yoilsho	1179	2	two	two	CD
cord-006229-7yoilsho	1179	3	weeks	week	NNS
cord-006229-7yoilsho	1179	4	of	of	IN
cord-006229-7yoilsho	1179	5	in	in	IN
cord-006229-7yoilsho	1179	6	vitro	vitro	FW
cord-006229-7yoilsho	1179	7	culture	culture	NN
cord-006229-7yoilsho	1179	8	,	,	,
cord-006229-7yoilsho	1179	9	the	the	DT
cord-006229-7yoilsho	1179	10	skin	skin	NN
cord-006229-7yoilsho	1179	11	constructs	construct	NNS
cord-006229-7yoilsho	1179	12	were	be	VBD
cord-006229-7yoilsho	1179	13	processed	process	VBN
cord-006229-7yoilsho	1179	14	for	for	IN
cord-006229-7yoilsho	1179	15	quantitative	quantitative	JJ
cord-006229-7yoilsho	1179	16	as	as	RB
cord-006229-7yoilsho	1179	17	well	well	RB
cord-006229-7yoilsho	1179	18	as	as	IN
cord-006229-7yoilsho	1179	19	qualitative	qualitative	JJ
cord-006229-7yoilsho	1179	20	assessment	assessment	NN
cord-006229-7yoilsho	1179	21	by	by	IN
cord-006229-7yoilsho	1179	22	light	light	NN
cord-006229-7yoilsho	1179	23	and	and	CC
cord-006229-7yoilsho	1179	24	electron	electron	NN
cord-006229-7yoilsho	1179	25	microscopy	microscopy	NN
cord-006229-7yoilsho	1179	26	.	.	.
cord-006229-7yoilsho	1180	1	Results	result	NNS
cord-006229-7yoilsho	1180	2	:	:	:
cord-006229-7yoilsho	1181	1	Both	both	DT
cord-006229-7yoilsho	1181	2	types	type	NNS
cord-006229-7yoilsho	1181	3	of	of	IN
cord-006229-7yoilsho	1181	4	skin	skin	NN
cord-006229-7yoilsho	1181	5	construct	construct	NN
cord-006229-7yoilsho	1181	6	developed	develop	VBN
cord-006229-7yoilsho	1181	7	all	all	DT
cord-006229-7yoilsho	1181	8	strata	stratum	NNS
cord-006229-7yoilsho	1181	9	,	,	,
cord-006229-7yoilsho	1181	10	i.e.	i.e.	FW
cord-006229-7yoilsho	1181	11	,	,	,
cord-006229-7yoilsho	1181	12	stratum	stratum	NN
cord-006229-7yoilsho	1181	13	basale	basale	NN
cord-006229-7yoilsho	1181	14	,	,	,
cord-006229-7yoilsho	1181	15	spinosum	spinosum	NNP
cord-006229-7yoilsho	1181	16	,	,	,
cord-006229-7yoilsho	1181	17	granulosum	granulosum	NNP
cord-006229-7yoilsho	1181	18	,	,	,
cord-006229-7yoilsho	1181	19	corneum	corneum	NN
cord-006229-7yoilsho	1181	20	of	of	IN
cord-006229-7yoilsho	1181	21	a	a	DT
cord-006229-7yoilsho	1181	22	stratified	stratified	JJ
cord-006229-7yoilsho	1181	23	soft	soft	RB
cord-006229-7yoilsho	1181	24	-	-	HYPH
cord-006229-7yoilsho	1181	25	cornified	cornified	JJ
cord-006229-7yoilsho	1181	26	epidermis	epidermis	NN
cord-006229-7yoilsho	1181	27	,	,	,
cord-006229-7yoilsho	1181	28	although	although	IN
cord-006229-7yoilsho	1181	29	the	the	DT
cord-006229-7yoilsho	1181	30	two	two	CD
cord-006229-7yoilsho	1181	31	constructs	construct	NNS
cord-006229-7yoilsho	1181	32	displayed	display	VBD
cord-006229-7yoilsho	1181	33	differences	difference	NNS
cord-006229-7yoilsho	1181	34	in	in	IN
cord-006229-7yoilsho	1181	35	every	every	DT
cord-006229-7yoilsho	1181	36	stratum	stratum	NN
cord-006229-7yoilsho	1181	37	:	:	:
cord-006229-7yoilsho	1181	38	Significantly	significantly	RB
cord-006229-7yoilsho	1181	39	more	more	JJR
cord-006229-7yoilsho	1181	40	mitoses	mitose	NNS
cord-006229-7yoilsho	1181	41	occurred	occur	VBD
cord-006229-7yoilsho	1181	42	in	in	IN
cord-006229-7yoilsho	1181	43	the	the	DT
cord-006229-7yoilsho	1181	44	epithelial	epithelial	JJ
cord-006229-7yoilsho	1181	45	germ	germ	NN
cord-006229-7yoilsho	1181	46	layers	layer	NNS
cord-006229-7yoilsho	1181	47	of	of	IN
cord-006229-7yoilsho	1181	48	the	the	DT
cord-006229-7yoilsho	1181	49	endothelialized	endothelialize	VBN
cord-006229-7yoilsho	1181	50	constructs	construct	NNS
cord-006229-7yoilsho	1181	51	(	(	-LRB-
cord-006229-7yoilsho	1181	52	p=0.013	p=0.013	NNP
cord-006229-7yoilsho	1181	53	)	)	-RRB-
cord-006229-7yoilsho	1181	54	.	.	.
cord-006229-7yoilsho	1182	1	In	in	IN
cord-006229-7yoilsho	1182	2	addition	addition	NN
cord-006229-7yoilsho	1182	3	,	,	,
cord-006229-7yoilsho	1182	4	significantly	significantly	RB
cord-006229-7yoilsho	1182	5	more	more	JJR
cord-006229-7yoilsho	1182	6	keratohyalin	keratohyalin	NN
cord-006229-7yoilsho	1182	7	granules	granule	NNS
cord-006229-7yoilsho	1182	8	were	be	VBD
cord-006229-7yoilsho	1182	9	counted	count	VBN
cord-006229-7yoilsho	1182	10	within	within	IN
cord-006229-7yoilsho	1182	11	their	-PRON-	PRP$
cord-006229-7yoilsho	1182	12	stratum	stratum	NN
cord-006229-7yoilsho	1182	13	granulosum	granulosum	NN
cord-006229-7yoilsho	1182	14	(	(	-LRB-
cord-006229-7yoilsho	1182	15	p=0.010	p=0.010	NNP
cord-006229-7yoilsho	1182	16	)	)	-RRB-
cord-006229-7yoilsho	1182	17	.	.	.
cord-006229-7yoilsho	1183	1	50	50	CD
cord-006229-7yoilsho	1183	2	%	%	NN
cord-006229-7yoilsho	1183	3	of	of	IN
cord-006229-7yoilsho	1183	4	the	the	DT
cord-006229-7yoilsho	1183	5	shapes	shape	NNS
cord-006229-7yoilsho	1183	6	of	of	IN
cord-006229-7yoilsho	1183	7	the	the	DT
cord-006229-7yoilsho	1183	8	spinous	spinous	JJ
cord-006229-7yoilsho	1183	9	and	and	CC
cord-006229-7yoilsho	1183	10	the	the	DT
cord-006229-7yoilsho	1183	11	granulosum	granulosum	NN
cord-006229-7yoilsho	1183	12	cells	cell	NNS
cord-006229-7yoilsho	1183	13	were	be	VBD
cord-006229-7yoilsho	1183	14	irregular	irregular	JJ
cord-006229-7yoilsho	1183	15	and	and	CC
cord-006229-7yoilsho	1183	16	these	these	DT
cord-006229-7yoilsho	1183	17	cells	cell	NNS
cord-006229-7yoilsho	1183	18	were	be	VBD
cord-006229-7yoilsho	1183	19	separated	separate	VBN
cord-006229-7yoilsho	1183	20	by	by	IN
cord-006229-7yoilsho	1183	21	wide	wide	JJ
cord-006229-7yoilsho	1183	22	intercellular	intercellular	JJ
cord-006229-7yoilsho	1183	23	spaces	space	NNS
cord-006229-7yoilsho	1183	24	.	.	.
cord-006229-7yoilsho	1184	1	The	the	DT
cord-006229-7yoilsho	1184	2	typical	typical	JJ
cord-006229-7yoilsho	1184	3	epidermal	epidermal	JJ
cord-006229-7yoilsho	1184	4	lamellar	lamellar	JJ
cord-006229-7yoilsho	1184	5	bodies	body	NNS
cord-006229-7yoilsho	1184	6	appeared	appear	VBD
cord-006229-7yoilsho	1184	7	in	in	IN
cord-006229-7yoilsho	1184	8	the	the	DT
cord-006229-7yoilsho	1184	9	endothelialized	endothelialize	VBN
cord-006229-7yoilsho	1184	10	constructs	construct	NNS
cord-006229-7yoilsho	1184	11	more	more	RBR
cord-006229-7yoilsho	1184	12	often	often	RB
cord-006229-7yoilsho	1184	13	than	than	IN
cord-006229-7yoilsho	1184	14	in	in	IN
cord-006229-7yoilsho	1184	15	the	the	DT
cord-006229-7yoilsho	1184	16	nonendothelialized	nonendothelialize	VBN
cord-006229-7yoilsho	1184	17	ones	one	NNS
cord-006229-7yoilsho	1184	18	.	.	.
cord-006229-7yoilsho	1185	1	At	at	IN
cord-006229-7yoilsho	1185	2	the	the	DT
cord-006229-7yoilsho	1185	3	stratum	stratum	NN
cord-006229-7yoilsho	1185	4	granulosum	granulosum	NN
cord-006229-7yoilsho	1185	5	-stratum	-stratum	HYPH
cord-006229-7yoilsho	1185	6	corneum	corneum	NNP
cord-006229-7yoilsho	1185	7	interface	interface	NN
cord-006229-7yoilsho	1185	8	,	,	,
cord-006229-7yoilsho	1185	9	no	no	DT
cord-006229-7yoilsho	1185	10	cohesion	cohesion	NN
cord-006229-7yoilsho	1185	11	between	between	IN
cord-006229-7yoilsho	1185	12	the	the	DT
cord-006229-7yoilsho	1185	13	strata	strata	NN
cord-006229-7yoilsho	1185	14	was	be	VBD
cord-006229-7yoilsho	1185	15	present	present	JJ
cord-006229-7yoilsho	1185	16	.	.	.
cord-006229-7yoilsho	1186	1	Background	background	NN
cord-006229-7yoilsho	1186	2	and	and	CC
cord-006229-7yoilsho	1186	3	novelty	novelty	NN
cord-006229-7yoilsho	1186	4	:	:	:
cord-006229-7yoilsho	1186	5	During	during	IN
cord-006229-7yoilsho	1186	6	the	the	DT
cord-006229-7yoilsho	1186	7	last	last	JJ
cord-006229-7yoilsho	1186	8	decade	decade	NN
cord-006229-7yoilsho	1186	9	organ	organ	NN
cord-006229-7yoilsho	1186	10	-	-	HYPH
cord-006229-7yoilsho	1186	11	on	on	IN
cord-006229-7yoilsho	1186	12	-	-	HYPH
cord-006229-7yoilsho	1186	13	a	a	DT
cord-006229-7yoilsho	1186	14	-	-	HYPH
cord-006229-7yoilsho	1186	15	chip	chip	NN
cord-006229-7yoilsho	1186	16	technologies	technology	NNS
cord-006229-7yoilsho	1186	17	received	receive	VBD
cord-006229-7yoilsho	1186	18	increasing	increase	VBG
cord-006229-7yoilsho	1186	19	attention	attention	NN
cord-006229-7yoilsho	1186	20	in	in	IN
cord-006229-7yoilsho	1186	21	the	the	DT
cord-006229-7yoilsho	1186	22	scientific	scientific	JJ
cord-006229-7yoilsho	1186	23	community	community	NN
cord-006229-7yoilsho	1186	24	.	.	.
cord-006229-7yoilsho	1187	1	The	the	DT
cord-006229-7yoilsho	1187	2	idea	idea	NN
cord-006229-7yoilsho	1187	3	of	of	IN
cord-006229-7yoilsho	1187	4	combining	combine	VBG
cord-006229-7yoilsho	1187	5	different	different	JJ
cord-006229-7yoilsho	1187	6	tissue	tissue	NN
cord-006229-7yoilsho	1187	7	types	type	NNS
cord-006229-7yoilsho	1187	8	on	on	IN
cord-006229-7yoilsho	1187	9	a	a	DT
cord-006229-7yoilsho	1187	10	physiological	physiological	JJ
cord-006229-7yoilsho	1187	11	-	-	HYPH
cord-006229-7yoilsho	1187	12	like	like	JJ
cord-006229-7yoilsho	1187	13	system	system	NN
cord-006229-7yoilsho	1187	14	creates	create	VBZ
cord-006229-7yoilsho	1187	15	completely	completely	RB
cord-006229-7yoilsho	1187	16	new	new	JJ
cord-006229-7yoilsho	1187	17	options	option	NNS
cord-006229-7yoilsho	1187	18	on	on	IN
cord-006229-7yoilsho	1187	19	how	how	WRB
cord-006229-7yoilsho	1187	20	substances	substance	NNS
cord-006229-7yoilsho	1187	21	can	can	MD
cord-006229-7yoilsho	1187	22	be	be	VB
cord-006229-7yoilsho	1187	23	characterized	characterize	VBN
cord-006229-7yoilsho	1187	24	without	without	IN
cord-006229-7yoilsho	1187	25	the	the	DT
cord-006229-7yoilsho	1187	26	use	use	NN
cord-006229-7yoilsho	1187	27	of	of	IN
cord-006229-7yoilsho	1187	28	animal	animal	NN
cord-006229-7yoilsho	1187	29	experiments	experiment	NNS
cord-006229-7yoilsho	1187	30	.	.	.
cord-006229-7yoilsho	1188	1	Animal	animal	NN
cord-006229-7yoilsho	1188	2	models	model	NNS
cord-006229-7yoilsho	1188	3	were	be	VBD
cord-006229-7yoilsho	1188	4	used	use	VBN
cord-006229-7yoilsho	1188	5	for	for	IN
cord-006229-7yoilsho	1188	6	the	the	DT
cord-006229-7yoilsho	1188	7	investigation	investigation	NN
cord-006229-7yoilsho	1188	8	of	of	IN
cord-006229-7yoilsho	1188	9	skin	skin	NN
cord-006229-7yoilsho	1188	10	sensitization	sensitization	NN
cord-006229-7yoilsho	1188	11	as	as	IN
cord-006229-7yoilsho	1188	12	a	a	DT
cord-006229-7yoilsho	1188	13	standard	standard	JJ
cord-006229-7yoilsho	1188	14	method	method	NN
cord-006229-7yoilsho	1188	15	until	until	IN
cord-006229-7yoilsho	1188	16	animal	animal	NN
cord-006229-7yoilsho	1188	17	testing	testing	NN
cord-006229-7yoilsho	1188	18	for	for	IN
cord-006229-7yoilsho	1188	19	cosmetic	cosmetic	JJ
cord-006229-7yoilsho	1188	20	substances	substance	NNS
cord-006229-7yoilsho	1188	21	was	be	VBD
cord-006229-7yoilsho	1188	22	banned	ban	VBN
cord-006229-7yoilsho	1188	23	in	in	IN
cord-006229-7yoilsho	1188	24	the	the	DT
cord-006229-7yoilsho	1188	25	E.U.	E.U.	NNP
cord-006229-7yoilsho	1188	26	in	in	IN
cord-006229-7yoilsho	1188	27	2013	2013	CD
cord-006229-7yoilsho	1188	28	.	.	.
cord-006229-7yoilsho	1189	1	By	by	IN
cord-006229-7yoilsho	1189	2	combining	combine	VBG
cord-006229-7yoilsho	1189	3	skin	skin	NN
cord-006229-7yoilsho	1189	4	models	model	NNS
cord-006229-7yoilsho	1189	5	with	with	IN
cord-006229-7yoilsho	1189	6	an	an	DT
cord-006229-7yoilsho	1189	7	immunological	immunological	JJ
cord-006229-7yoilsho	1189	8	counterpart	counterpart	NN
cord-006229-7yoilsho	1189	9	,	,	,
cord-006229-7yoilsho	1189	10	new	new	JJ
cord-006229-7yoilsho	1189	11	data	datum	NNS
cord-006229-7yoilsho	1189	12	will	will	MD
cord-006229-7yoilsho	1189	13	be	be	VB
cord-006229-7yoilsho	1189	14	presented	present	VBN
cord-006229-7yoilsho	1189	15	to	to	TO
cord-006229-7yoilsho	1189	16	see	see	VB
cord-006229-7yoilsho	1189	17	if	if	IN
cord-006229-7yoilsho	1189	18	the	the	DT
cord-006229-7yoilsho	1189	19	Multi	Multi	NNP
cord-006229-7yoilsho	1189	20	-	-	NNP
cord-006229-7yoilsho	1189	21	Organ	Organ	NNP
cord-006229-7yoilsho	1189	22	-	-	HYPH
cord-006229-7yoilsho	1189	23	Chip	chip	NN
cord-006229-7yoilsho	1189	24	add	add	VB
cord-006229-7yoilsho	1189	25	value	value	NN
cord-006229-7yoilsho	1189	26	to	to	IN
cord-006229-7yoilsho	1189	27	the	the	DT
cord-006229-7yoilsho	1189	28	current	current	JJ
cord-006229-7yoilsho	1189	29	need	need	NN
cord-006229-7yoilsho	1189	30	of	of	IN
cord-006229-7yoilsho	1189	31	alternative	alternative	JJ
cord-006229-7yoilsho	1189	32	methods	method	NNS
cord-006229-7yoilsho	1189	33	regarding	regard	VBG
cord-006229-7yoilsho	1189	34	skin	skin	NN
cord-006229-7yoilsho	1189	35	sensitization	sensitization	NN
cord-006229-7yoilsho	1189	36	and	and	CC
cord-006229-7yoilsho	1189	37	immunotoxicity	immunotoxicity	NN
cord-006229-7yoilsho	1189	38	testing	testing	NN
cord-006229-7yoilsho	1189	39	.	.	.
cord-006229-7yoilsho	1190	1	Experimental	experimental	JJ
cord-006229-7yoilsho	1190	2	approach	approach	NN
cord-006229-7yoilsho	1190	3	:	:	:
cord-006229-7yoilsho	1190	4	The	the	DT
cord-006229-7yoilsho	1190	5	Multi	Multi	NNP
cord-006229-7yoilsho	1190	6	-	-	HYPH
cord-006229-7yoilsho	1190	7	Organ	Organ	NNP
cord-006229-7yoilsho	1190	8	-	-	HYPH
cord-006229-7yoilsho	1190	9	Chip	Chip	NNP
cord-006229-7yoilsho	1190	10	platform	platform	NN
cord-006229-7yoilsho	1190	11	is	be	VBZ
cord-006229-7yoilsho	1190	12	designed	design	VBN
cord-006229-7yoilsho	1190	13	to	to	TO
cord-006229-7yoilsho	1190	14	combine	combine	VB
cord-006229-7yoilsho	1190	15	different	different	JJ
cord-006229-7yoilsho	1190	16	human	human	JJ
cord-006229-7yoilsho	1190	17	cell	cell	NN
cord-006229-7yoilsho	1190	18	and	and	CC
cord-006229-7yoilsho	1190	19	tissue	tissue	NN
cord-006229-7yoilsho	1190	20	types	type	NNS
cord-006229-7yoilsho	1190	21	like	like	IN
cord-006229-7yoilsho	1190	22	3D	3d	NN
cord-006229-7yoilsho	1190	23	-	-	HYPH
cord-006229-7yoilsho	1190	24	spheroids	spheroid	NNS
cord-006229-7yoilsho	1190	25	,	,	,
cord-006229-7yoilsho	1190	26	barrier	barrier	NN
cord-006229-7yoilsho	1190	27	models	model	NNS
cord-006229-7yoilsho	1190	28	or	or	CC
cord-006229-7yoilsho	1190	29	biopsies	biopsy	NNS
cord-006229-7yoilsho	1190	30	in	in	IN
cord-006229-7yoilsho	1190	31	one	one	CD
cord-006229-7yoilsho	1190	32	microfluidic	microfluidic	JJ
cord-006229-7yoilsho	1190	33	system	system	NN
cord-006229-7yoilsho	1190	34	.	.	.
cord-006229-7yoilsho	1191	1	A	a	DT
cord-006229-7yoilsho	1191	2	peristaltic	peristaltic	JJ
cord-006229-7yoilsho	1191	3	on	on	IN
cord-006229-7yoilsho	1191	4	-	-	HYPH
cord-006229-7yoilsho	1191	5	chip	chip	NN
cord-006229-7yoilsho	1191	6	micropump	micropump	NN
cord-006229-7yoilsho	1191	7	enables	enable	VBZ
cord-006229-7yoilsho	1191	8	circulation	circulation	NN
cord-006229-7yoilsho	1191	9	of	of	IN
cord-006229-7yoilsho	1191	10	medium	medium	NN
cord-006229-7yoilsho	1191	11	,	,	,
cord-006229-7yoilsho	1191	12	allowing	allow	VBG
cord-006229-7yoilsho	1191	13	for	for	IN
cord-006229-7yoilsho	1191	14	a	a	DT
cord-006229-7yoilsho	1191	15	constant	constant	JJ
cord-006229-7yoilsho	1191	16	perfusion	perfusion	NN
cord-006229-7yoilsho	1191	17	between	between	IN
cord-006229-7yoilsho	1191	18	the	the	DT
cord-006229-7yoilsho	1191	19	compartments	compartment	NNS
cord-006229-7yoilsho	1191	20	.	.	.
cord-006229-7yoilsho	1192	1	First	first	JJ
cord-006229-7yoilsho	1192	2	experiments	experiment	NNS
cord-006229-7yoilsho	1192	3	were	be	VBD
cord-006229-7yoilsho	1192	4	performed	perform	VBN
cord-006229-7yoilsho	1192	5	using	use	VBG
cord-006229-7yoilsho	1192	6	a	a	DT
cord-006229-7yoilsho	1192	7	dendritic	dendritic	JJ
cord-006229-7yoilsho	1192	8	-	-	HYPH
cord-006229-7yoilsho	1192	9	cell	cell	NN
cord-006229-7yoilsho	1192	10	-	-	HYPH
cord-006229-7yoilsho	1192	11	only	only	RB
cord-006229-7yoilsho	1192	12	approach	approach	NN
cord-006229-7yoilsho	1192	13	in	in	IN
cord-006229-7yoilsho	1192	14	the	the	DT
cord-006229-7yoilsho	1192	15	2-Organ	2-Organ	NNP
cord-006229-7yoilsho	1192	16	-	-	HYPH
cord-006229-7yoilsho	1192	17	Chip	chip	NN
cord-006229-7yoilsho	1192	18	.	.	.
cord-006229-7yoilsho	1193	1	In	in	IN
cord-006229-7yoilsho	1193	2	subsequent	subsequent	JJ
cord-006229-7yoilsho	1193	3	cocultivation	cocultivation	NN
cord-006229-7yoilsho	1193	4	experiments	experiment	NNS
cord-006229-7yoilsho	1193	5	ex	ex	NNP
cord-006229-7yoilsho	1193	6	vivo	vivo	NNP
cord-006229-7yoilsho	1193	7	human	human	JJ
cord-006229-7yoilsho	1193	8	epidermis	epidermis	NN
cord-006229-7yoilsho	1193	9	and	and	CC
cord-006229-7yoilsho	1193	10	dendritic	dendritic	JJ
cord-006229-7yoilsho	1193	11	cells	cell	NNS
cord-006229-7yoilsho	1193	12	were	be	VBD
cord-006229-7yoilsho	1193	13	cultivated	cultivate	VBN
cord-006229-7yoilsho	1193	14	each	each	DT
cord-006229-7yoilsho	1193	15	in	in	IN
cord-006229-7yoilsho	1193	16	one	one	CD
cord-006229-7yoilsho	1193	17	culture	culture	NN
cord-006229-7yoilsho	1193	18	compartment	compartment	NN
cord-006229-7yoilsho	1193	19	connected	connect	VBN
cord-006229-7yoilsho	1193	20	by	by	IN
cord-006229-7yoilsho	1193	21	the	the	DT
cord-006229-7yoilsho	1193	22	microfluidic	microfluidic	JJ
cord-006229-7yoilsho	1193	23	channels	channel	NNS
cord-006229-7yoilsho	1193	24	.	.	.
cord-006229-7yoilsho	1194	1	For	for	IN
cord-006229-7yoilsho	1194	2	analysis	analysis	NN
cord-006229-7yoilsho	1194	3	we	-PRON-	PRP
cord-006229-7yoilsho	1194	4	measured	measure	VBD
cord-006229-7yoilsho	1194	5	the	the	DT
cord-006229-7yoilsho	1194	6	typical	typical	JJ
cord-006229-7yoilsho	1194	7	activation	activation	NN
cord-006229-7yoilsho	1194	8	marker	marker	NN
cord-006229-7yoilsho	1194	9	CD86	CD86	NNP
cord-006229-7yoilsho	1194	10	and	and	CC
cord-006229-7yoilsho	1194	11	the	the	DT
cord-006229-7yoilsho	1194	12	vitality	vitality	NN
cord-006229-7yoilsho	1194	13	of	of	IN
cord-006229-7yoilsho	1194	14	the	the	DT
cord-006229-7yoilsho	1194	15	dendritic	dendritic	JJ
cord-006229-7yoilsho	1194	16	cells	cell	NNS
cord-006229-7yoilsho	1194	17	by	by	IN
cord-006229-7yoilsho	1194	18	flow	flow	NN
cord-006229-7yoilsho	1194	19	cytometry	cytometry	NN
cord-006229-7yoilsho	1194	20	.	.	.
cord-006229-7yoilsho	1195	1	Functionally	functionally	RB
cord-006229-7yoilsho	1195	2	different	different	JJ
cord-006229-7yoilsho	1195	3	sensitizers	sensitizer	NNS
cord-006229-7yoilsho	1195	4	were	be	VBD
cord-006229-7yoilsho	1195	5	selected	select	VBN
cord-006229-7yoilsho	1195	6	to	to	TO
cord-006229-7yoilsho	1195	7	investigate	investigate	VB
cord-006229-7yoilsho	1195	8	their	-PRON-	PRP$
cord-006229-7yoilsho	1195	9	effects	effect	NNS
cord-006229-7yoilsho	1195	10	in	in	IN
cord-006229-7yoilsho	1195	11	our	-PRON-	PRP$
cord-006229-7yoilsho	1195	12	model	model	NN
cord-006229-7yoilsho	1195	13	.	.	.
cord-006229-7yoilsho	1196	1	Finally	finally	RB
cord-006229-7yoilsho	1196	2	a	a	DT
cord-006229-7yoilsho	1196	3	more	more	RBR
cord-006229-7yoilsho	1196	4	complex	complex	JJ
cord-006229-7yoilsho	1196	5	3D	3d	JJ
cord-006229-7yoilsho	1196	6	matrices	matrix	NNS
cord-006229-7yoilsho	1196	7	including	include	VBG
cord-006229-7yoilsho	1196	8	different	different	JJ
cord-006229-7yoilsho	1196	9	immunological	immunological	JJ
cord-006229-7yoilsho	1196	10	cell	cell	NN
cord-006229-7yoilsho	1196	11	types	type	NNS
cord-006229-7yoilsho	1196	12	to	to	TO
cord-006229-7yoilsho	1196	13	emulate	emulate	VB
cord-006229-7yoilsho	1196	14	in	in	IN
cord-006229-7yoilsho	1196	15	vivo	vivo	NN
cord-006229-7yoilsho	1196	16	-	-	HYPH
cord-006229-7yoilsho	1196	17	like	like	JJ
cord-006229-7yoilsho	1196	18	reactions	reaction	NNS
cord-006229-7yoilsho	1196	19	like	like	IN
cord-006229-7yoilsho	1196	20	in	in	IN
cord-006229-7yoilsho	1196	21	the	the	DT
cord-006229-7yoilsho	1196	22	human	human	JJ
cord-006229-7yoilsho	1196	23	lymph	lymph	NN
cord-006229-7yoilsho	1196	24	node	node	NN
cord-006229-7yoilsho	1196	25	were	be	VBD
cord-006229-7yoilsho	1196	26	cultivated	cultivate	VBN
cord-006229-7yoilsho	1196	27	in	in	IN
cord-006229-7yoilsho	1196	28	the	the	DT
cord-006229-7yoilsho	1196	29	2-Organ	2-Organ	NNP
cord-006229-7yoilsho	1196	30	-	-	HYPH
cord-006229-7yoilsho	1196	31	Chip	chip	NN
cord-006229-7yoilsho	1196	32	.	.	.
cord-006229-7yoilsho	1197	1	Results	result	NNS
cord-006229-7yoilsho	1197	2	and	and	CC
cord-006229-7yoilsho	1197	3	discussion	discussion	NN
cord-006229-7yoilsho	1198	1	:	:	:
cord-006229-7yoilsho	1198	2	Our	-PRON-	PRP$
cord-006229-7yoilsho	1198	3	data	datum	NNS
cord-006229-7yoilsho	1198	4	show	show	VBP
cord-006229-7yoilsho	1198	5	a	a	DT
cord-006229-7yoilsho	1198	6	strong	strong	JJ
cord-006229-7yoilsho	1198	7	influence	influence	NN
cord-006229-7yoilsho	1198	8	of	of	IN
cord-006229-7yoilsho	1198	9	pump	pump	NN
cord-006229-7yoilsho	1198	10	pressure	pressure	NN
cord-006229-7yoilsho	1198	11	and	and	CC
cord-006229-7yoilsho	1198	12	pumping	pump	VBG
cord-006229-7yoilsho	1198	13	frequency	frequency	NN
cord-006229-7yoilsho	1198	14	on	on	IN
cord-006229-7yoilsho	1198	15	the	the	DT
cord-006229-7yoilsho	1198	16	activation	activation	NN
cord-006229-7yoilsho	1198	17	of	of	IN
cord-006229-7yoilsho	1198	18	dendritic	dendritic	JJ
cord-006229-7yoilsho	1198	19	cells	cell	NNS
cord-006229-7yoilsho	1198	20	.	.	.
cord-006229-7yoilsho	1199	1	Hence	hence	RB
cord-006229-7yoilsho	1199	2	,	,	,
cord-006229-7yoilsho	1199	3	we	-PRON-	PRP
cord-006229-7yoilsho	1199	4	established	establish	VBD
cord-006229-7yoilsho	1199	5	an	an	DT
cord-006229-7yoilsho	1199	6	adequate	adequate	NN
cord-006229-7yoilsho	1199	7	set	set	NN
cord-006229-7yoilsho	1199	8	up	up	RP
cord-006229-7yoilsho	1199	9	by	by	IN
cord-006229-7yoilsho	1199	10	cultivating	cultivate	VBG
cord-006229-7yoilsho	1199	11	the	the	DT
cord-006229-7yoilsho	1199	12	dendritic	dendritic	JJ
cord-006229-7yoilsho	1199	13	cells	cell	NNS
cord-006229-7yoilsho	1199	14	in	in	IN
cord-006229-7yoilsho	1199	15	cell	cell	NN
cord-006229-7yoilsho	1199	16	culture	culture	NN
cord-006229-7yoilsho	1199	17	inserts	insert	NNS
cord-006229-7yoilsho	1199	18	,	,	,
cord-006229-7yoilsho	1199	19	preventing	prevent	VBG
cord-006229-7yoilsho	1199	20	cell	cell	NN
cord-006229-7yoilsho	1199	21	activation	activation	NN
cord-006229-7yoilsho	1199	22	due	due	IN
cord-006229-7yoilsho	1199	23	to	to	TO
cord-006229-7yoilsho	1199	24	shear	shear	VB
cord-006229-7yoilsho	1199	25	stress	stress	NN
cord-006229-7yoilsho	1199	26	.	.	.
cord-006229-7yoilsho	1200	1	Compared	compare	VBN
cord-006229-7yoilsho	1200	2	to	to	IN
cord-006229-7yoilsho	1200	3	existing	exist	VBG
cord-006229-7yoilsho	1200	4	sensitization	sensitization	NN
cord-006229-7yoilsho	1200	5	assays	assay	NNS
cord-006229-7yoilsho	1200	6	,	,	,
cord-006229-7yoilsho	1200	7	the	the	DT
cord-006229-7yoilsho	1200	8	main	main	JJ
cord-006229-7yoilsho	1200	9	advantage	advantage	NN
cord-006229-7yoilsho	1200	10	of	of	IN
cord-006229-7yoilsho	1200	11	the	the	DT
cord-006229-7yoilsho	1200	12	perfused	perfuse	VBN
cord-006229-7yoilsho	1200	13	2-Organ	2-organ	CD
cord-006229-7yoilsho	1200	14	-	-	HYPH
cord-006229-7yoilsho	1200	15	Chip	chip	NN
cord-006229-7yoilsho	1200	16	sensitization	sensitization	NN
cord-006229-7yoilsho	1200	17	assay	assay	NN
cord-006229-7yoilsho	1200	18	is	be	VBZ
cord-006229-7yoilsho	1200	19	the	the	DT
cord-006229-7yoilsho	1200	20	presence	presence	NN
cord-006229-7yoilsho	1200	21	of	of	IN
cord-006229-7yoilsho	1200	22	an	an	DT
cord-006229-7yoilsho	1200	23	epidermis	epidermis	NN
cord-006229-7yoilsho	1200	24	equivalent	equivalent	NN
cord-006229-7yoilsho	1200	25	,	,	,
cord-006229-7yoilsho	1200	26	partially	partially	RB
cord-006229-7yoilsho	1200	27	integrating	integrate	VBG
cord-006229-7yoilsho	1200	28	important	important	JJ
cord-006229-7yoilsho	1200	29	parameters	parameter	NNS
cord-006229-7yoilsho	1200	30	such	such	JJ
cord-006229-7yoilsho	1200	31	as	as	IN
cord-006229-7yoilsho	1200	32	metabolism	metabolism	NN
cord-006229-7yoilsho	1200	33	and	and	CC
cord-006229-7yoilsho	1200	34	skin	skin	NN
cord-006229-7yoilsho	1200	35	barrier	barrier	NN
cord-006229-7yoilsho	1200	36	function	function	NN
cord-006229-7yoilsho	1200	37	.	.	.
cord-006229-7yoilsho	1201	1	We	-PRON-	PRP
cord-006229-7yoilsho	1201	2	compared	compare	VBD
cord-006229-7yoilsho	1201	3	our	-PRON-	PRP$
cord-006229-7yoilsho	1201	4	data	datum	NNS
cord-006229-7yoilsho	1201	5	with	with	IN
cord-006229-7yoilsho	1201	6	reference	reference	NN
cord-006229-7yoilsho	1201	7	CD86-values	CD86-values	NNP
cord-006229-7yoilsho	1201	8	from	from	IN
cord-006229-7yoilsho	1201	9	the	the	DT
cord-006229-7yoilsho	1201	10	PBMDC	PBMDC	NNP
cord-006229-7yoilsho	1202	1	(	(	-LRB-
cord-006229-7yoilsho	1202	2	peripheral	peripheral	JJ
cord-006229-7yoilsho	1202	3	blood	blood	NN
cord-006229-7yoilsho	1202	4	monocyte	monocyte	NNP
cord-006229-7yoilsho	1202	5	derived	derive	VBD
cord-006229-7yoilsho	1202	6	dendritic	dendritic	JJ
cord-006229-7yoilsho	1202	7	cells	cell	NNS
cord-006229-7yoilsho	1202	8	)	)	-RRB-
cord-006229-7yoilsho	1202	9	skin	skin	NN
cord-006229-7yoilsho	1202	10	sensitization	sensitization	NN
cord-006229-7yoilsho	1202	11	assay	assay	NN
cord-006229-7yoilsho	1202	12	.	.	.
cord-006229-7yoilsho	1203	1	For	for	IN
cord-006229-7yoilsho	1203	2	identical	identical	JJ
cord-006229-7yoilsho	1203	3	substances	substance	NNS
cord-006229-7yoilsho	1203	4	,	,	,
cord-006229-7yoilsho	1203	5	we	-PRON-	PRP
cord-006229-7yoilsho	1203	6	observed	observe	VBD
cord-006229-7yoilsho	1203	7	differences	difference	NNS
cord-006229-7yoilsho	1203	8	in	in	IN
cord-006229-7yoilsho	1203	9	dendritic	dendritic	JJ
cord-006229-7yoilsho	1203	10	cell	cell	NN
cord-006229-7yoilsho	1203	11	activation	activation	NN
cord-006229-7yoilsho	1203	12	between	between	IN
cord-006229-7yoilsho	1203	13	the	the	DT
cord-006229-7yoilsho	1203	14	PBMDC	PBMDC	NNP
cord-006229-7yoilsho	1203	15	assay	assay	NN
cord-006229-7yoilsho	1203	16	and	and	CC
cord-006229-7yoilsho	1203	17	the	the	DT
cord-006229-7yoilsho	1203	18	2-Organ	2-organ	CD
cord-006229-7yoilsho	1203	19	-	-	HYPH
cord-006229-7yoilsho	1203	20	Chip	chip	NN
cord-006229-7yoilsho	1203	21	perfused	perfuse	VBN
cord-006229-7yoilsho	1203	22	assay	assay	NN
cord-006229-7yoilsho	1203	23	.	.	.
cord-006229-7yoilsho	1204	1	Here	here	RB
cord-006229-7yoilsho	1204	2	we	-PRON-	PRP
cord-006229-7yoilsho	1204	3	present	present	VBP
cord-006229-7yoilsho	1204	4	the	the	DT
cord-006229-7yoilsho	1204	5	first	first	JJ
cord-006229-7yoilsho	1204	6	-	-	HYPH
cord-006229-7yoilsho	1204	7	time	time	NN
cord-006229-7yoilsho	1204	8	cultivation	cultivation	NN
cord-006229-7yoilsho	1204	9	of	of	IN
cord-006229-7yoilsho	1204	10	primary	primary	JJ
cord-006229-7yoilsho	1204	11	derived	derive	VBN
cord-006229-7yoilsho	1204	12	immune	immune	JJ
cord-006229-7yoilsho	1204	13	cells	cell	NNS
cord-006229-7yoilsho	1204	14	cultivated	cultivate	VBN
cord-006229-7yoilsho	1204	15	on	on	IN
cord-006229-7yoilsho	1204	16	our	-PRON-	PRP$
cord-006229-7yoilsho	1204	17	microfluidic	microfluidic	JJ
cord-006229-7yoilsho	1204	18	system	system	NN
cord-006229-7yoilsho	1204	19	which	which	WDT
cord-006229-7yoilsho	1204	20	is	be	VBZ
cord-006229-7yoilsho	1204	21	a	a	DT
cord-006229-7yoilsho	1204	22	promising	promising	JJ
cord-006229-7yoilsho	1204	23	enhancement	enhancement	NN
cord-006229-7yoilsho	1204	24	to	to	TO
cord-006229-7yoilsho	1204	25	integrate	integrate	VB
cord-006229-7yoilsho	1204	26	immunological	immunological	JJ
cord-006229-7yoilsho	1204	27	reactions	reaction	NNS
cord-006229-7yoilsho	1204	28	on	on	IN
cord-006229-7yoilsho	1204	29	further	further	JJ
cord-006229-7yoilsho	1204	30	multi	multi	JJ
cord-006229-7yoilsho	1204	31	-	-	JJ
cord-006229-7yoilsho	1204	32	organ	organ	JJ
cord-006229-7yoilsho	1204	33	combinations	combination	NNS
cord-006229-7yoilsho	1204	34	.	.	.
cord-006229-7yoilsho	1205	1	Due	due	IN
cord-006229-7yoilsho	1205	2	to	to	IN
cord-006229-7yoilsho	1205	3	growing	grow	VBG
cord-006229-7yoilsho	1205	4	social	social	JJ
cord-006229-7yoilsho	1205	5	and	and	CC
cord-006229-7yoilsho	1205	6	political	political	JJ
cord-006229-7yoilsho	1205	7	pressure	pressure	NN
cord-006229-7yoilsho	1205	8	,	,	,
cord-006229-7yoilsho	1205	9	the	the	DT
cord-006229-7yoilsho	1205	10	interest	interest	NN
cord-006229-7yoilsho	1205	11	in	in	IN
cord-006229-7yoilsho	1205	12	alternatives	alternative	NNS
cord-006229-7yoilsho	1205	13	to	to	IN
cord-006229-7yoilsho	1205	14	animal	animal	NN
cord-006229-7yoilsho	1205	15	testing	testing	NN
cord-006229-7yoilsho	1205	16	has	have	VBZ
cord-006229-7yoilsho	1205	17	constantly	constantly	RB
cord-006229-7yoilsho	1205	18	increased	increase	VBN
cord-006229-7yoilsho	1205	19	during	during	IN
cord-006229-7yoilsho	1205	20	the	the	DT
cord-006229-7yoilsho	1205	21	past	past	JJ
cord-006229-7yoilsho	1205	22	10	10	CD
cord-006229-7yoilsho	1205	23	years	year	NNS
cord-006229-7yoilsho	1205	24	stimulating	stimulate	VBG
cord-006229-7yoilsho	1205	25	the	the	DT
cord-006229-7yoilsho	1205	26	development	development	NN
cord-006229-7yoilsho	1205	27	and	and	CC
cord-006229-7yoilsho	1205	28	validation	validation	NN
cord-006229-7yoilsho	1205	29	of	of	IN
cord-006229-7yoilsho	1205	30	new	new	JJ
cord-006229-7yoilsho	1205	31	in	in	FW
cord-006229-7yoilsho	1205	32	vitro	vitro	FW
cord-006229-7yoilsho	1205	33	test	test	NN
cord-006229-7yoilsho	1205	34	systems	system	NNS
cord-006229-7yoilsho	1205	35	including	include	VBG
cord-006229-7yoilsho	1205	36	reconstructed	reconstruct	VBN
cord-006229-7yoilsho	1205	37	skin	skin	NN
cord-006229-7yoilsho	1205	38	models	model	NNS
cord-006229-7yoilsho	1205	39	.	.	.
cord-006229-7yoilsho	1206	1	Additional	additional	JJ
cord-006229-7yoilsho	1206	2	to	to	IN
cord-006229-7yoilsho	1206	3	toxicological	toxicological	JJ
cord-006229-7yoilsho	1206	4	studies	study	NNS
cord-006229-7yoilsho	1206	5	and	and	CC
cord-006229-7yoilsho	1206	6	permeability	permeability	NN
cord-006229-7yoilsho	1206	7	assays	assay	NNS
cord-006229-7yoilsho	1206	8	,	,	,
cord-006229-7yoilsho	1206	9	skin	skin	NN
cord-006229-7yoilsho	1206	10	models	model	NNS
cord-006229-7yoilsho	1206	11	are	be	VBP
cord-006229-7yoilsho	1206	12	of	of	IN
cord-006229-7yoilsho	1206	13	high	high	JJ
cord-006229-7yoilsho	1206	14	interest	interest	NN
cord-006229-7yoilsho	1206	15	for	for	IN
cord-006229-7yoilsho	1206	16	fundamental	fundamental	JJ
cord-006229-7yoilsho	1206	17	research	research	NN
cord-006229-7yoilsho	1206	18	to	to	TO
cord-006229-7yoilsho	1206	19	elucidate	elucidate	VB
cord-006229-7yoilsho	1206	20	basic	basic	JJ
cord-006229-7yoilsho	1206	21	physiological	physiological	JJ
cord-006229-7yoilsho	1206	22	and	and	CC
cord-006229-7yoilsho	1206	23	pathophysiological	pathophysiological	JJ
cord-006229-7yoilsho	1206	24	processes	process	NNS
cord-006229-7yoilsho	1206	25	in	in	IN
cord-006229-7yoilsho	1206	26	human	human	JJ
cord-006229-7yoilsho	1206	27	skin	skin	NN
cord-006229-7yoilsho	1206	28	[	[	-LRB-
cord-006229-7yoilsho	1206	29	1	1	CD
cord-006229-7yoilsho	1206	30	,	,	,
cord-006229-7yoilsho	1206	31	2	2	CD
cord-006229-7yoilsho	1206	32	]	]	-RRB-
cord-006229-7yoilsho	1206	33	.	.	.
cord-006229-7yoilsho	1207	1	As	as	IN
cord-006229-7yoilsho	1207	2	for	for	IN
cord-006229-7yoilsho	1207	3	today	today	NN
cord-006229-7yoilsho	1207	4	,	,	,
cord-006229-7yoilsho	1207	5	most	most	JJS
cord-006229-7yoilsho	1207	6	of	of	IN
cord-006229-7yoilsho	1207	7	the	the	DT
cord-006229-7yoilsho	1207	8	in	in	FW
cord-006229-7yoilsho	1207	9	vitro	vitro	FW
cord-006229-7yoilsho	1207	10	skin	skin	NN
cord-006229-7yoilsho	1207	11	models	model	NNS
cord-006229-7yoilsho	1207	12	are	be	VBP
cord-006229-7yoilsho	1207	13	grown	grow	VBN
cord-006229-7yoilsho	1207	14	from	from	IN
cord-006229-7yoilsho	1207	15	primary	primary	JJ
cord-006229-7yoilsho	1207	16	keratinocytes	keratinocyte	NNS
cord-006229-7yoilsho	1207	17	and	and	CC
cord-006229-7yoilsho	1207	18	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	1207	19	that	that	WDT
cord-006229-7yoilsho	1207	20	were	be	VBD
cord-006229-7yoilsho	1207	21	either	either	RB
cord-006229-7yoilsho	1207	22	isolated	isolate	VBN
cord-006229-7yoilsho	1207	23	from	from	IN
cord-006229-7yoilsho	1207	24	excised	excise	VBN
cord-006229-7yoilsho	1207	25	human	human	JJ
cord-006229-7yoilsho	1207	26	skin	skin	NN
cord-006229-7yoilsho	1207	27	or	or	CC
cord-006229-7yoilsho	1207	28	from	from	IN
cord-006229-7yoilsho	1207	29	juvenile	juvenile	JJ
cord-006229-7yoilsho	1207	30	foreskin	foreskin	NN
cord-006229-7yoilsho	1207	31	following	follow	VBG
cord-006229-7yoilsho	1207	32	circumcision	circumcision	NN
cord-006229-7yoilsho	1207	33	.	.	.
cord-006229-7yoilsho	1208	1	In	in	IN
cord-006229-7yoilsho	1208	2	this	this	DT
cord-006229-7yoilsho	1208	3	project	project	NN
cord-006229-7yoilsho	1208	4	,	,	,
cord-006229-7yoilsho	1208	5	we	-PRON-	PRP
cord-006229-7yoilsho	1208	6	aimed	aim	VBD
cord-006229-7yoilsho	1208	7	for	for	IN
cord-006229-7yoilsho	1208	8	the	the	DT
cord-006229-7yoilsho	1208	9	generation	generation	NN
cord-006229-7yoilsho	1208	10	of	of	IN
cord-006229-7yoilsho	1208	11	in	in	FW
cord-006229-7yoilsho	1208	12	vitro	vitro	FW
cord-006229-7yoilsho	1208	13	skin	skin	NN
cord-006229-7yoilsho	1208	14	models	model	NNS
cord-006229-7yoilsho	1208	15	using	use	VBG
cord-006229-7yoilsho	1208	16	hair	hair	NN
cord-006229-7yoilsho	1208	17	folliclederived	folliclederive	VBN
cord-006229-7yoilsho	1208	18	cells	cell	NNS
cord-006229-7yoilsho	1208	19	.	.	.
cord-006229-7yoilsho	1209	1	Therefore	therefore	RB
cord-006229-7yoilsho	1209	2	,	,	,
cord-006229-7yoilsho	1209	3	different	different	JJ
cord-006229-7yoilsho	1209	4	methods	method	NNS
cord-006229-7yoilsho	1209	5	to	to	TO
cord-006229-7yoilsho	1209	6	optimize	optimize	VB
cord-006229-7yoilsho	1209	7	cell	cell	NN
cord-006229-7yoilsho	1209	8	isolation	isolation	NN
cord-006229-7yoilsho	1209	9	and	and	CC
cord-006229-7yoilsho	1209	10	expansion	expansion	NN
cord-006229-7yoilsho	1209	11	of	of	IN
cord-006229-7yoilsho	1209	12	outer	outer	JJ
cord-006229-7yoilsho	1209	13	root	root	NN
cord-006229-7yoilsho	1209	14	sheath	sheath	NN
cord-006229-7yoilsho	1209	15	(	(	-LRB-
cord-006229-7yoilsho	1209	16	ORS	ORS	NNP
cord-006229-7yoilsho	1209	17	)	)	-RRB-
cord-006229-7yoilsho	1209	18	cells	cell	NNS
cord-006229-7yoilsho	1209	19	from	from	IN
cord-006229-7yoilsho	1209	20	human	human	JJ
cord-006229-7yoilsho	1209	21	hair	hair	NN
cord-006229-7yoilsho	1209	22	follicles	follicle	NNS
cord-006229-7yoilsho	1209	23	were	be	VBD
cord-006229-7yoilsho	1209	24	systematically	systematically	RB
cord-006229-7yoilsho	1209	25	investigated	investigate	VBN
cord-006229-7yoilsho	1209	26	.	.	.
cord-006229-7yoilsho	1210	1	The	the	DT
cord-006229-7yoilsho	1210	2	best	good	JJS
cord-006229-7yoilsho	1210	3	procedure	procedure	NN
cord-006229-7yoilsho	1210	4	for	for	IN
cord-006229-7yoilsho	1210	5	isolation	isolation	NN
cord-006229-7yoilsho	1210	6	of	of	IN
cord-006229-7yoilsho	1210	7	ORS	ORS	NNP
cord-006229-7yoilsho	1210	8	cells	cell	NNS
cord-006229-7yoilsho	1210	9	was	be	VBD
cord-006229-7yoilsho	1210	10	the	the	DT
cord-006229-7yoilsho	1210	11	direct	direct	JJ
cord-006229-7yoilsho	1210	12	cell	cell	NN
cord-006229-7yoilsho	1210	13	outgrowth	outgrowth	NN
cord-006229-7yoilsho	1210	14	on	on	IN
cord-006229-7yoilsho	1210	15	a	a	DT
cord-006229-7yoilsho	1210	16	cell	cell	NN
cord-006229-7yoilsho	1210	17	culture	culture	NN
cord-006229-7yoilsho	1210	18	insert	insert	NN
cord-006229-7yoilsho	1210	19	which	which	WDT
cord-006229-7yoilsho	1210	20	was	be	VBD
cord-006229-7yoilsho	1210	21	co	co	JJ
cord-006229-7yoilsho	1210	22	-	-	JJ
cord-006229-7yoilsho	1210	23	cultured	cultured	JJ
cord-006229-7yoilsho	1210	24	with	with	IN
cord-006229-7yoilsho	1210	25	a	a	DT
cord-006229-7yoilsho	1210	26	feeder	feeder	NN
cord-006229-7yoilsho	1210	27	layer	layer	NN
cord-006229-7yoilsho	1210	28	of	of	IN
cord-006229-7yoilsho	1210	29	postmitotic	postmitotic	JJ
cord-006229-7yoilsho	1210	30	human	human	JJ
cord-006229-7yoilsho	1210	31	dermal	dermal	JJ
cord-006229-7yoilsho	1210	32	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	1210	33	.	.	.
cord-006229-7yoilsho	1211	1	Following	follow	VBG
cord-006229-7yoilsho	1211	2	outgrowth	outgrowth	NN
cord-006229-7yoilsho	1211	3	,	,	,
cord-006229-7yoilsho	1211	4	the	the	DT
cord-006229-7yoilsho	1211	5	cells	cell	NNS
cord-006229-7yoilsho	1211	6	were	be	VBD
cord-006229-7yoilsho	1211	7	either	either	CC
cord-006229-7yoilsho	1211	8	further	further	RB
cord-006229-7yoilsho	1211	9	cultivated	cultivate	VBN
cord-006229-7yoilsho	1211	10	with	with	IN
cord-006229-7yoilsho	1211	11	feeder	feeder	NN
cord-006229-7yoilsho	1211	12	cells	cell	NNS
cord-006229-7yoilsho	1211	13	in	in	IN
cord-006229-7yoilsho	1211	14	specific	specific	JJ
cord-006229-7yoilsho	1211	15	serum	serum	NN
cord-006229-7yoilsho	1211	16	-	-	HYPH
cord-006229-7yoilsho	1211	17	enriched	enrich	VBN
cord-006229-7yoilsho	1211	18	cell	cell	NN
cord-006229-7yoilsho	1211	19	culture	culture	NN
cord-006229-7yoilsho	1211	20	medium	medium	NN
cord-006229-7yoilsho	1211	21	to	to	TO
cord-006229-7yoilsho	1211	22	obtain	obtain	VB
cord-006229-7yoilsho	1211	23	hair	hair	NN
cord-006229-7yoilsho	1211	24	follicle	follicle	NN
cord-006229-7yoilsho	1211	25	-	-	HYPH
cord-006229-7yoilsho	1211	26	derived	derive	VBN
cord-006229-7yoilsho	1211	27	keratinocytes	keratinocyte	NNS
cord-006229-7yoilsho	1211	28	or	or	CC
cord-006229-7yoilsho	1211	29	using	use	VBG
cord-006229-7yoilsho	1211	30	the	the	DT
cord-006229-7yoilsho	1211	31	same	same	JJ
cord-006229-7yoilsho	1211	32	culture	culture	NN
cord-006229-7yoilsho	1211	33	medium	medium	NN
cord-006229-7yoilsho	1211	34	without	without	IN
cord-006229-7yoilsho	1211	35	feeder	feeder	NN
cord-006229-7yoilsho	1211	36	cells	cell	NNS
cord-006229-7yoilsho	1211	37	to	to	TO
cord-006229-7yoilsho	1211	38	obtain	obtain	VB
cord-006229-7yoilsho	1211	39	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	1211	40	.	.	.
cord-006229-7yoilsho	1212	1	Afterwards	afterwards	RB
cord-006229-7yoilsho	1212	2	,	,	,
cord-006229-7yoilsho	1212	3	the	the	DT
cord-006229-7yoilsho	1212	4	generation	generation	NN
cord-006229-7yoilsho	1212	5	of	of	IN
cord-006229-7yoilsho	1212	6	hair	hair	NN
cord-006229-7yoilsho	1212	7	follicle	follicle	NN
cord-006229-7yoilsho	1212	8	-	-	HYPH
cord-006229-7yoilsho	1212	9	derived	derive	VBN
cord-006229-7yoilsho	1212	10	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	1212	11	and	and	CC
cord-006229-7yoilsho	1212	12	keratinocytes	keratinocyte	NNS
cord-006229-7yoilsho	1212	13	was	be	VBD
cord-006229-7yoilsho	1212	14	verified	verify	VBN
cord-006229-7yoilsho	1212	15	via	via	IN
cord-006229-7yoilsho	1212	16	the	the	DT
cord-006229-7yoilsho	1212	17	fibroblast	fibroblast	NN
cord-006229-7yoilsho	1212	18	-	-	HYPH
cord-006229-7yoilsho	1212	19	specific	specific	JJ
cord-006229-7yoilsho	1212	20	markers	marker	NNS
cord-006229-7yoilsho	1212	21	vimentin	vimentin	UH
cord-006229-7yoilsho	1212	22	and	and	CC
cord-006229-7yoilsho	1212	23	desmin	desmin	NNP
cord-006229-7yoilsho	1212	24	and	and	CC
cord-006229-7yoilsho	1212	25	the	the	DT
cord-006229-7yoilsho	1212	26	keratinocyte	keratinocyte	NNP
cord-006229-7yoilsho	1212	27	marker	marker	NNP
cord-006229-7yoilsho	1212	28	cytokeratin	cytokeratin	NNP
cord-006229-7yoilsho	1212	29	(	(	-LRB-
cord-006229-7yoilsho	1212	30	CK	CK	NNP
cord-006229-7yoilsho	1212	31	)	)	-RRB-
cord-006229-7yoilsho	1212	32	14	14	CD
cord-006229-7yoilsho	1212	33	clearly	clearly	RB
cord-006229-7yoilsho	1212	34	showing	show	VBG
cord-006229-7yoilsho	1212	35	that	that	IN
cord-006229-7yoilsho	1212	36	vimentin	vimentin	NNS
cord-006229-7yoilsho	1212	37	and	and	CC
cord-006229-7yoilsho	1212	38	desmin	desmin	NNP
cord-006229-7yoilsho	1212	39	are	be	VBP
cord-006229-7yoilsho	1212	40	expressed	express	VBN
cord-006229-7yoilsho	1212	41	in	in	IN
cord-006229-7yoilsho	1212	42	hair	hair	NN
cord-006229-7yoilsho	1212	43	follicle	follicle	NN
cord-006229-7yoilsho	1212	44	-	-	HYPH
cord-006229-7yoilsho	1212	45	derived	derive	VBN
cord-006229-7yoilsho	1212	46	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	1212	47	and	and	CC
cord-006229-7yoilsho	1212	48	in	in	IN
cord-006229-7yoilsho	1212	49	dermal	dermal	JJ
cord-006229-7yoilsho	1212	50	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	1212	51	.	.	.
cord-006229-7yoilsho	1213	1	As	as	IN
cord-006229-7yoilsho	1213	2	expected	expect	VBN
cord-006229-7yoilsho	1213	3	,	,	,
cord-006229-7yoilsho	1213	4	these	these	DT
cord-006229-7yoilsho	1213	5	cells	cell	NNS
cord-006229-7yoilsho	1213	6	were	be	VBD
cord-006229-7yoilsho	1213	7	negative	negative	JJ
cord-006229-7yoilsho	1213	8	for	for	IN
cord-006229-7yoilsho	1213	9	CK14	CK14	NNP
cord-006229-7yoilsho	1213	10	,	,	,
cord-006229-7yoilsho	1213	11	which	which	WDT
cord-006229-7yoilsho	1213	12	was	be	VBD
cord-006229-7yoilsho	1213	13	abundantly	abundantly	RB
cord-006229-7yoilsho	1213	14	expressed	express	VBN
cord-006229-7yoilsho	1213	15	in	in	IN
cord-006229-7yoilsho	1213	16	hair	hair	NN
cord-006229-7yoilsho	1213	17	folliclederived	folliclederived	JJ
cord-006229-7yoilsho	1213	18	keratinocytes	keratinocyte	NNS
cord-006229-7yoilsho	1213	19	.	.	.
cord-006229-7yoilsho	1214	1	Moreover	moreover	RB
cord-006229-7yoilsho	1214	2	,	,	,
cord-006229-7yoilsho	1214	3	the	the	DT
cord-006229-7yoilsho	1214	4	expression	expression	NN
cord-006229-7yoilsho	1214	5	of	of	IN
cord-006229-7yoilsho	1214	6	collagen	collagen	NN
cord-006229-7yoilsho	1214	7	type	type	NN
cord-006229-7yoilsho	1214	8	I	I	NNP
cord-006229-7yoilsho	1214	9	,	,	,
cord-006229-7yoilsho	1214	10	IV	IV	NNP
cord-006229-7yoilsho	1214	11	,	,	,
cord-006229-7yoilsho	1214	12	TGF	TGF	NNP
cord-006229-7yoilsho	1214	13	-	-	HYPH
cord-006229-7yoilsho	1214	14	beta	beta	NN
cord-006229-7yoilsho	1214	15	,	,	,
cord-006229-7yoilsho	1214	16	alpha	alpha	NN
cord-006229-7yoilsho	1214	17	SMA	SMA	NNP
cord-006229-7yoilsho	1214	18	and	and	CC
cord-006229-7yoilsho	1214	19	IL-1	IL-1	NNP
cord-006229-7yoilsho	1214	20	alpha	alpha	NN
cord-006229-7yoilsho	1214	21	in	in	IN
cord-006229-7yoilsho	1214	22	hair	hair	NN
cord-006229-7yoilsho	1214	23	follicle	follicle	NN
cord-006229-7yoilsho	1214	24	-	-	HYPH
cord-006229-7yoilsho	1214	25	derived	derive	VBN
cord-006229-7yoilsho	1214	26	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	1214	27	and	and	CC
cord-006229-7yoilsho	1214	28	dermal	dermal	JJ
cord-006229-7yoilsho	1214	29	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	1214	30	showed	show	VBD
cord-006229-7yoilsho	1214	31	no	no	DT
cord-006229-7yoilsho	1214	32	significant	significant	JJ
cord-006229-7yoilsho	1214	33	differences	difference	NNS
cord-006229-7yoilsho	1214	34	.	.	.
cord-006229-7yoilsho	1215	1	Ultimately	ultimately	RB
cord-006229-7yoilsho	1215	2	,	,	,
cord-006229-7yoilsho	1215	3	hair	hair	NN
cord-006229-7yoilsho	1215	4	follicle	follicle	NN
cord-006229-7yoilsho	1215	5	-	-	HYPH
cord-006229-7yoilsho	1215	6	derived	derive	VBN
cord-006229-7yoilsho	1215	7	keratinocytes	keratinocyte	NNS
cord-006229-7yoilsho	1215	8	and	and	CC
cord-006229-7yoilsho	1215	9	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	1215	10	were	be	VBD
cord-006229-7yoilsho	1215	11	used	use	VBN
cord-006229-7yoilsho	1215	12	to	to	TO
cord-006229-7yoilsho	1215	13	grow	grow	VB
cord-006229-7yoilsho	1215	14	full	full	JJ
cord-006229-7yoilsho	1215	15	-	-	HYPH
cord-006229-7yoilsho	1215	16	thickness	thickness	NN
cord-006229-7yoilsho	1215	17	skin	skin	NN
cord-006229-7yoilsho	1215	18	models	model	NNS
cord-006229-7yoilsho	1215	19	which	which	WDT
cord-006229-7yoilsho	1215	20	were	be	VBD
cord-006229-7yoilsho	1215	21	subsequently	subsequently	RB
cord-006229-7yoilsho	1215	22	characterized	characterize	VBN
cord-006229-7yoilsho	1215	23	with	with	IN
cord-006229-7yoilsho	1215	24	regard	regard	NN
cord-006229-7yoilsho	1215	25	to	to	IN
cord-006229-7yoilsho	1215	26	epidermal	epidermal	JJ
cord-006229-7yoilsho	1215	27	differentiation	differentiation	NN
cord-006229-7yoilsho	1215	28	,	,	,
cord-006229-7yoilsho	1215	29	skin	skin	NN
cord-006229-7yoilsho	1215	30	permeability	permeability	NN
cord-006229-7yoilsho	1215	31	and	and	CC
cord-006229-7yoilsho	1215	32	skin	skin	NN
cord-006229-7yoilsho	1215	33	surface	surface	NN
cord-006229-7yoilsho	1216	1	pH.	pH.	NNP
cord-006229-7yoilsho	1217	1	Again	again	RB
cord-006229-7yoilsho	1217	2	,	,	,
cord-006229-7yoilsho	1217	3	no	no	DT
cord-006229-7yoilsho	1217	4	significant	significant	JJ
cord-006229-7yoilsho	1217	5	differences	difference	NNS
cord-006229-7yoilsho	1217	6	compared	compare	VBN
cord-006229-7yoilsho	1217	7	with	with	IN
cord-006229-7yoilsho	1217	8	skin	skin	NN
cord-006229-7yoilsho	1217	9	models	model	NNS
cord-006229-7yoilsho	1217	10	grown	grow	VBN
cord-006229-7yoilsho	1217	11	from	from	IN
cord-006229-7yoilsho	1217	12	skin	skin	NN
cord-006229-7yoilsho	1217	13	-	-	HYPH
cord-006229-7yoilsho	1217	14	derived	derive	VBN
cord-006229-7yoilsho	1217	15	cells	cell	NNS
cord-006229-7yoilsho	1217	16	were	be	VBD
cord-006229-7yoilsho	1217	17	detected	detect	VBN
cord-006229-7yoilsho	1217	18	showing	show	VBG
cord-006229-7yoilsho	1217	19	the	the	DT
cord-006229-7yoilsho	1217	20	potential	potential	NN
cord-006229-7yoilsho	1217	21	of	of	IN
cord-006229-7yoilsho	1217	22	using	use	VBG
cord-006229-7yoilsho	1217	23	hair	hair	NN
cord-006229-7yoilsho	1217	24	follicle	follicle	NN
cord-006229-7yoilsho	1217	25	-	-	HYPH
cord-006229-7yoilsho	1217	26	derived	derive	VBN
cord-006229-7yoilsho	1217	27	cells	cell	NNS
cord-006229-7yoilsho	1217	28	for	for	IN
cord-006229-7yoilsho	1217	29	generating	generate	VBG
cord-006229-7yoilsho	1217	30	in	in	IN
cord-006229-7yoilsho	1217	31	vitro	vitro	FW
cord-006229-7yoilsho	1217	32	skin	skin	NN
cord-006229-7yoilsho	1217	33	models	model	NNS
cord-006229-7yoilsho	1217	34	.	.	.
cord-006229-7yoilsho	1218	1	[	[	-LRB-
cord-006229-7yoilsho	1218	2	1	1	LS
cord-006229-7yoilsho	1218	3	]	]	-RRB-
cord-006229-7yoilsho	1218	4	Vávrová	Vávrová	NNP
cord-006229-7yoilsho	1218	5	,	,	,
cord-006229-7yoilsho	1218	6	K.	K.	NNP
cord-006229-7yoilsho	1218	7	,	,	,
cord-006229-7yoilsho	1218	8	Henkes	Henkes	NNP
cord-006229-7yoilsho	1218	9	,	,	,
cord-006229-7yoilsho	1218	10	D.	D.	NNP
cord-006229-7yoilsho	1218	11	,	,	,
cord-006229-7yoilsho	1218	12	Strüver	Strüver	NNP
cord-006229-7yoilsho	1218	13	,	,	,
cord-006229-7yoilsho	1218	14	K.	K.	NNP
cord-006229-7yoilsho	1218	15	,	,	,
cord-006229-7yoilsho	1218	16	Sochorová	Sochorová	NNP
cord-006229-7yoilsho	1218	17	,	,	,
cord-006229-7yoilsho	1218	18	M.	M.	NNP
cord-006229-7yoilsho	1218	19	,	,	,
cord-006229-7yoilsho	1218	20	Školová	Školová	NNP
cord-006229-7yoilsho	1218	21	,	,	,
cord-006229-7yoilsho	1218	22	B.	B.	NNP
cord-006229-7yoilsho	1218	23	et	et	NNP
cord-006229-7yoilsho	1218	24	al	al	NNP
cord-006229-7yoilsho	1218	25	.	.	.
cord-006229-7yoilsho	1219	1	Filaggrin	Filaggrin	NNP
cord-006229-7yoilsho	1219	2	deficiency	deficiency	NN
cord-006229-7yoilsho	1219	3	leads	lead	VBZ
cord-006229-7yoilsho	1219	4	to	to	IN
cord-006229-7yoilsho	1219	5	impaired	impaired	JJ
cord-006229-7yoilsho	1219	6	lipid	lipid	NN
cord-006229-7yoilsho	1219	7	profile	profile	NN
cord-006229-7yoilsho	1219	8	and	and	CC
cord-006229-7yoilsho	1219	9	altered	alter	VBD
cord-006229-7yoilsho	1219	10	acidification	acidification	NN
cord-006229-7yoilsho	1219	11	pathways	pathway	NNS
cord-006229-7yoilsho	1219	12	in	in	IN
cord-006229-7yoilsho	1219	13	a	a	DT
cord-006229-7yoilsho	1219	14	3D	3d	JJ
cord-006229-7yoilsho	1219	15	skin	skin	NN
cord-006229-7yoilsho	1219	16	construct	construct	NN
cord-006229-7yoilsho	1219	17	.	.	.
cord-006229-7yoilsho	1220	1	The	the	DT
cord-006229-7yoilsho	1220	2	Journal	Journal	NNP
cord-006229-7yoilsho	1220	3	of	of	IN
cord-006229-7yoilsho	1220	4	Investigative	Investigative	NNP
cord-006229-7yoilsho	1220	5	Dermatology	Dermatology	NNP
cord-006229-7yoilsho	1220	6	.	.	.
cord-006229-7yoilsho	1221	1	134	134	CD
cord-006229-7yoilsho	1221	2	,	,	,
cord-006229-7yoilsho	1221	3	746	746	CD
cord-006229-7yoilsho	1221	4	-	-	HYPH
cord-006229-7yoilsho	1221	5	753	753	CD
cord-006229-7yoilsho	1221	6	(	(	-LRB-
cord-006229-7yoilsho	1221	7	2014	2014	CD
cord-006229-7yoilsho	1221	8	Bundesinstitut	Bundesinstitut	NNP
cord-006229-7yoilsho	1221	9	für	für	NNP
cord-006229-7yoilsho	1221	10	Risikobewertung	Risikobewertung	NNP
cord-006229-7yoilsho	1221	11	,	,	,
cord-006229-7yoilsho	1221	12	Experimentelle	Experimentelle	NNP
cord-006229-7yoilsho	1221	13	Toxikologie	Toxikologie	NNP
cord-006229-7yoilsho	1221	14	und	und	VBD
cord-006229-7yoilsho	1221	15	ZEBET	ZEBET	NNP
cord-006229-7yoilsho	1221	16	,	,	,
cord-006229-7yoilsho	1221	17	Berlin	Berlin	NNP
cord-006229-7yoilsho	1221	18	,	,	,
cord-006229-7yoilsho	1222	1	Germany	Germany	NNP
cord-006229-7yoilsho	1222	2	Background	Background	NNP
cord-006229-7yoilsho	1222	3	:	:	:
cord-006229-7yoilsho	1223	1	The	the	DT
cord-006229-7yoilsho	1223	2	EU	EU	NNP
cord-006229-7yoilsho	1223	3	Directive	Directive	NNP
cord-006229-7yoilsho	1223	4	2010/63	2010/63	CD
cord-006229-7yoilsho	1223	5	has	have	VBZ
cord-006229-7yoilsho	1223	6	been	be	VBN
cord-006229-7yoilsho	1223	7	drawn	draw	VBN
cord-006229-7yoilsho	1223	8	up	up	RP
cord-006229-7yoilsho	1223	9	with	with	IN
cord-006229-7yoilsho	1223	10	the	the	DT
cord-006229-7yoilsho	1223	11	aim	aim	NN
cord-006229-7yoilsho	1223	12	of	of	IN
cord-006229-7yoilsho	1223	13	ultimately	ultimately	RB
cord-006229-7yoilsho	1223	14	replacing	replace	VBG
cord-006229-7yoilsho	1223	15	animal	animal	NN
cord-006229-7yoilsho	1223	16	testing	testing	NN
cord-006229-7yoilsho	1223	17	.	.	.
cord-006229-7yoilsho	1224	1	Wherever	wherever	WRB
cord-006229-7yoilsho	1224	2	animal	animal	NN
cord-006229-7yoilsho	1224	3	experimentation	experimentation	NN
cord-006229-7yoilsho	1224	4	is	be	VBZ
cord-006229-7yoilsho	1224	5	necessary	necessary	JJ
cord-006229-7yoilsho	1224	6	,	,	,
cord-006229-7yoilsho	1224	7	the	the	DT
cord-006229-7yoilsho	1224	8	3-Rprinciple	3-Rprinciple	NNP
cord-006229-7yoilsho	1224	9	of	of	IN
cord-006229-7yoilsho	1224	10	Russel	Russel	NNP
cord-006229-7yoilsho	1224	11	and	and	CC
cord-006229-7yoilsho	1224	12	Burch	Burch	NNP
cord-006229-7yoilsho	1225	1	(	(	-LRB-
cord-006229-7yoilsho	1225	2	replace	replace	VB
cord-006229-7yoilsho	1225	3	,	,	,
cord-006229-7yoilsho	1225	4	reduce	reduce	VB
cord-006229-7yoilsho	1225	5	,	,	,
cord-006229-7yoilsho	1225	6	refine	refine	VB
cord-006229-7yoilsho	1225	7	)	)	-RRB-
cord-006229-7yoilsho	1225	8	has	have	VBZ
cord-006229-7yoilsho	1225	9	to	to	TO
cord-006229-7yoilsho	1225	10	be	be	VB
cord-006229-7yoilsho	1225	11	observed	observe	VBN
cord-006229-7yoilsho	1225	12	.	.	.
cord-006229-7yoilsho	1226	1	The	the	DT
cord-006229-7yoilsho	1226	2	primary	primary	JJ
cord-006229-7yoilsho	1226	3	goal	goal	NN
cord-006229-7yoilsho	1226	4	of	of	IN
cord-006229-7yoilsho	1226	5	the	the	DT
cord-006229-7yoilsho	1226	6	3-R	3-r	CD
cord-006229-7yoilsho	1226	7	-	-	NN
cord-006229-7yoilsho	1226	8	principle	principle	NN
cord-006229-7yoilsho	1226	9	is	be	VBZ
cord-006229-7yoilsho	1226	10	to	to	TO
cord-006229-7yoilsho	1226	11	replace	replace	VB
cord-006229-7yoilsho	1226	12	animal	animal	NN
cord-006229-7yoilsho	1226	13	testing	testing	NN
cord-006229-7yoilsho	1226	14	with	with	IN
cord-006229-7yoilsho	1226	15	alternative	alternative	JJ
cord-006229-7yoilsho	1226	16	methods	method	NNS
cord-006229-7yoilsho	1226	17	.	.	.
cord-006229-7yoilsho	1227	1	If	if	IN
cord-006229-7yoilsho	1227	2	no	no	DT
cord-006229-7yoilsho	1227	3	alternative	alternative	JJ
cord-006229-7yoilsho	1227	4	method	method	NN
cord-006229-7yoilsho	1227	5	can	can	MD
cord-006229-7yoilsho	1227	6	be	be	VB
cord-006229-7yoilsho	1227	7	applied	apply	VBN
cord-006229-7yoilsho	1227	8	,	,	,
cord-006229-7yoilsho	1227	9	the	the	DT
cord-006229-7yoilsho	1227	10	total	total	JJ
cord-006229-7yoilsho	1227	11	number	number	NN
cord-006229-7yoilsho	1227	12	of	of	IN
cord-006229-7yoilsho	1227	13	animals	animal	NNS
cord-006229-7yoilsho	1227	14	is	be	VBZ
cord-006229-7yoilsho	1227	15	supposed	suppose	VBN
cord-006229-7yoilsho	1227	16	be	be	VB
cord-006229-7yoilsho	1227	17	reduced	reduce	VBN
cord-006229-7yoilsho	1227	18	.	.	.
cord-006229-7yoilsho	1228	1	Consequently	consequently	RB
cord-006229-7yoilsho	1228	2	,	,	,
cord-006229-7yoilsho	1228	3	some	some	DT
cord-006229-7yoilsho	1228	4	animals	animal	NNS
cord-006229-7yoilsho	1228	5	are	be	VBP
cord-006229-7yoilsho	1228	6	used	use	VBN
cord-006229-7yoilsho	1228	7	multiple	multiple	JJ
cord-006229-7yoilsho	1228	8	times	time	NNS
cord-006229-7yoilsho	1228	9	in	in	IN
cord-006229-7yoilsho	1228	10	the	the	DT
cord-006229-7yoilsho	1228	11	course	course	NN
cord-006229-7yoilsho	1228	12	of	of	IN
cord-006229-7yoilsho	1228	13	an	an	DT
cord-006229-7yoilsho	1228	14	experiment	experiment	NN
cord-006229-7yoilsho	1228	15	.	.	.
cord-006229-7yoilsho	1229	1	For	for	IN
cord-006229-7yoilsho	1229	2	example	example	NN
cord-006229-7yoilsho	1229	3	,	,	,
cord-006229-7yoilsho	1229	4	in	in	IN
cord-006229-7yoilsho	1229	5	imaging	imaging	NN
cord-006229-7yoilsho	1229	6	studies	study	NNS
cord-006229-7yoilsho	1229	7	,	,	,
cord-006229-7yoilsho	1229	8	rodents	rodent	NNS
cord-006229-7yoilsho	1229	9	are	be	VBP
cord-006229-7yoilsho	1229	10	exposed	expose	VBN
cord-006229-7yoilsho	1229	11	to	to	IN
cord-006229-7yoilsho	1229	12	anesthesia	anesthesia	NN
cord-006229-7yoilsho	1229	13	several	several	JJ
cord-006229-7yoilsho	1229	14	times	time	NNS
cord-006229-7yoilsho	1229	15	in	in	IN
cord-006229-7yoilsho	1229	16	order	order	NN
cord-006229-7yoilsho	1229	17	to	to	TO
cord-006229-7yoilsho	1229	18	control	control	VB
cord-006229-7yoilsho	1229	19	the	the	DT
cord-006229-7yoilsho	1229	20	progress	progress	NN
cord-006229-7yoilsho	1229	21	of	of	IN
cord-006229-7yoilsho	1229	22	a	a	DT
cord-006229-7yoilsho	1229	23	disease	disease	NN
cord-006229-7yoilsho	1229	24	.	.	.
cord-006229-7yoilsho	1230	1	However	however	RB
cord-006229-7yoilsho	1230	2	,	,	,
cord-006229-7yoilsho	1230	3	the	the	DT
cord-006229-7yoilsho	1230	4	Directive	Directive	NNP
cord-006229-7yoilsho	1230	5	claims	claim	VBZ
cord-006229-7yoilsho	1230	6	that	that	IN
cord-006229-7yoilsho	1230	7	"	"	``
cord-006229-7yoilsho	1230	8	the	the	DT
cord-006229-7yoilsho	1230	9	benefit	benefit	NN
cord-006229-7yoilsho	1230	10	of	of	IN
cord-006229-7yoilsho	1230	11	reusing	reuse	VBG
cord-006229-7yoilsho	1230	12	animals	animal	NNS
cord-006229-7yoilsho	1230	13	should	should	MD
cord-006229-7yoilsho	1230	14	be	be	VB
cord-006229-7yoilsho	1230	15	balanced	balance	VBN
cord-006229-7yoilsho	1230	16	against	against	IN
cord-006229-7yoilsho	1230	17	any	any	DT
cord-006229-7yoilsho	1230	18	adverse	adverse	JJ
cord-006229-7yoilsho	1230	19	effects	effect	NNS
cord-006229-7yoilsho	1230	20	on	on	IN
cord-006229-7yoilsho	1230	21	their	-PRON-	PRP$
cord-006229-7yoilsho	1230	22	welfare	welfare	NN
cord-006229-7yoilsho	1230	23	,	,	,
cord-006229-7yoilsho	1230	24	taking	take	VBG
cord-006229-7yoilsho	1230	25	into	into	IN
cord-006229-7yoilsho	1230	26	account	account	NN
cord-006229-7yoilsho	1230	27	the	the	DT
cord-006229-7yoilsho	1230	28	lifetime	lifetime	NN
cord-006229-7yoilsho	1230	29	experience	experience	NN
cord-006229-7yoilsho	1230	30	of	of	IN
cord-006229-7yoilsho	1230	31	the	the	DT
cord-006229-7yoilsho	1230	32	individual	individual	JJ
cord-006229-7yoilsho	1230	33	animal	animal	NN
cord-006229-7yoilsho	1230	34	"	"	''
cord-006229-7yoilsho	1230	35	.	.	.
cord-006229-7yoilsho	1231	1	Objective	objective	NN
cord-006229-7yoilsho	1231	2	:	:	:
cord-006229-7yoilsho	1232	1	We	-PRON-	PRP
cord-006229-7yoilsho	1232	2	are	be	VBP
cord-006229-7yoilsho	1232	3	looking	look	VBG
cord-006229-7yoilsho	1232	4	into	into	IN
cord-006229-7yoilsho	1232	5	whether	whether	IN
cord-006229-7yoilsho	1232	6	multiple	multiple	JJ
cord-006229-7yoilsho	1232	7	exposures	exposure	NNS
cord-006229-7yoilsho	1232	8	to	to	IN
cord-006229-7yoilsho	1232	9	anesthesia	anesthesia	NN
cord-006229-7yoilsho	1232	10	cause	cause	VBP
cord-006229-7yoilsho	1232	11	more	more	JJR
cord-006229-7yoilsho	1232	12	stress	stress	NN
cord-006229-7yoilsho	1232	13	than	than	IN
cord-006229-7yoilsho	1232	14	a	a	DT
cord-006229-7yoilsho	1232	15	single	single	JJ
cord-006229-7yoilsho	1232	16	exposure	exposure	NN
cord-006229-7yoilsho	1232	17	.	.	.
cord-006229-7yoilsho	1233	1	Methods	method	NNS
cord-006229-7yoilsho	1233	2	:	:	:
cord-006229-7yoilsho	1234	1	The	the	DT
cord-006229-7yoilsho	1234	2	most	most	RBS
cord-006229-7yoilsho	1234	3	common	common	JJ
cord-006229-7yoilsho	1234	4	mouse	mouse	NN
cord-006229-7yoilsho	1234	5	strain	strain	NN
cord-006229-7yoilsho	1234	6	C57	C57	NNP
cord-006229-7yoilsho	1234	7	/	/	SYM
cord-006229-7yoilsho	1234	8	BL6	BL6	NNP
cord-006229-7yoilsho	1234	9	J	J	NNP
cord-006229-7yoilsho	1234	10	and	and	CC
cord-006229-7yoilsho	1234	11	anesthetics	anesthetic	NNS
cord-006229-7yoilsho	1234	12	isoflurane	isoflurane	NNP
cord-006229-7yoilsho	1234	13	and	and	CC
cord-006229-7yoilsho	1234	14	the	the	DT
cord-006229-7yoilsho	1234	15	combination	combination	NN
cord-006229-7yoilsho	1234	16	of	of	IN
cord-006229-7yoilsho	1234	17	ketamine	ketamine	NN
cord-006229-7yoilsho	1234	18	/	/	SYM
cord-006229-7yoilsho	1234	19	xylazine	xylazine	NNP
cord-006229-7yoilsho	1234	20	are	be	VBP
cord-006229-7yoilsho	1234	21	used	use	VBN
cord-006229-7yoilsho	1234	22	.	.	.
cord-006229-7yoilsho	1235	1	With	with	IN
cord-006229-7yoilsho	1235	2	regard	regard	NN
cord-006229-7yoilsho	1235	3	to	to	IN
cord-006229-7yoilsho	1235	4	recent	recent	JJ
cord-006229-7yoilsho	1235	5	studies	study	NNS
cord-006229-7yoilsho	1235	6	,	,	,
cord-006229-7yoilsho	1235	7	the	the	DT
cord-006229-7yoilsho	1235	8	animals	animal	NNS
cord-006229-7yoilsho	1235	9	are	be	VBP
cord-006229-7yoilsho	1235	10	anesthetized	anesthetize	VBN
cord-006229-7yoilsho	1235	11	six	six	CD
cord-006229-7yoilsho	1235	12	times	time	NNS
cord-006229-7yoilsho	1235	13	for	for	IN
cord-006229-7yoilsho	1235	14	45	45	CD
cord-006229-7yoilsho	1235	15	minutes	minute	NNS
cord-006229-7yoilsho	1235	16	over	over	IN
cord-006229-7yoilsho	1235	17	a	a	DT
cord-006229-7yoilsho	1235	18	period	period	NN
cord-006229-7yoilsho	1235	19	of	of	IN
cord-006229-7yoilsho	1235	20	three	three	CD
cord-006229-7yoilsho	1235	21	weeks	week	NNS
cord-006229-7yoilsho	1235	22	.	.	.
cord-006229-7yoilsho	1236	1	All	all	DT
cord-006229-7yoilsho	1236	2	parameters	parameter	NNS
cord-006229-7yoilsho	1236	3	observed	observe	VBD
cord-006229-7yoilsho	1236	4	are	be	VBP
cord-006229-7yoilsho	1236	5	compared	compare	VBN
cord-006229-7yoilsho	1236	6	between	between	IN
cord-006229-7yoilsho	1236	7	controls	control	NNS
cord-006229-7yoilsho	1236	8	,	,	,
cord-006229-7yoilsho	1236	9	animals	animal	NNS
cord-006229-7yoilsho	1236	10	with	with	IN
cord-006229-7yoilsho	1236	11	a	a	DT
cord-006229-7yoilsho	1236	12	single	single	JJ
cord-006229-7yoilsho	1236	13	and	and	CC
cord-006229-7yoilsho	1236	14	repeated	repeated	JJ
cord-006229-7yoilsho	1236	15	anesthesia	anesthesia	NN
cord-006229-7yoilsho	1236	16	.	.	.
cord-006229-7yoilsho	1237	1	The	the	DT
cord-006229-7yoilsho	1237	2	interval	interval	NN
cord-006229-7yoilsho	1237	3	between	between	IN
cord-006229-7yoilsho	1237	4	the	the	DT
cord-006229-7yoilsho	1237	5	administration	administration	NN
cord-006229-7yoilsho	1237	6	of	of	IN
cord-006229-7yoilsho	1237	7	the	the	DT
cord-006229-7yoilsho	1237	8	anesthesias	anesthesias	NNP
cord-006229-7yoilsho	1237	9	is	be	VBZ
cord-006229-7yoilsho	1237	10	three	three	CD
cord-006229-7yoilsho	1237	11	to	to	TO
cord-006229-7yoilsho	1237	12	four	four	CD
cord-006229-7yoilsho	1237	13	days	day	NNS
cord-006229-7yoilsho	1237	14	.	.	.
cord-006229-7yoilsho	1238	1	When	when	WRB
cord-006229-7yoilsho	1238	2	the	the	DT
cord-006229-7yoilsho	1238	3	animals	animal	NNS
cord-006229-7yoilsho	1238	4	are	be	VBP
cord-006229-7yoilsho	1238	5	under	under	IN
cord-006229-7yoilsho	1238	6	anesthesia	anesthesia	NN
cord-006229-7yoilsho	1238	7	,	,	,
cord-006229-7yoilsho	1238	8	their	-PRON-	PRP$
cord-006229-7yoilsho	1238	9	vital	vital	JJ
cord-006229-7yoilsho	1238	10	parameters	parameter	NNS
cord-006229-7yoilsho	1238	11	are	be	VBP
cord-006229-7yoilsho	1238	12	continuously	continuously	RB
cord-006229-7yoilsho	1238	13	monitored	monitor	VBN
cord-006229-7yoilsho	1238	14	and	and	CC
cord-006229-7yoilsho	1238	15	afterwards	afterwards	RB
cord-006229-7yoilsho	1238	16	their	-PRON-	PRP$
cord-006229-7yoilsho	1238	17	general	general	JJ
cord-006229-7yoilsho	1238	18	condition	condition	NN
cord-006229-7yoilsho	1238	19	is	be	VBZ
cord-006229-7yoilsho	1238	20	examined	examine	VBN
cord-006229-7yoilsho	1238	21	.	.	.
cord-006229-7yoilsho	1239	1	The	the	DT
cord-006229-7yoilsho	1239	2	grimace	grimace	NN
cord-006229-7yoilsho	1239	3	scale	scale	NN
cord-006229-7yoilsho	1239	4	is	be	VBZ
cord-006229-7yoilsho	1239	5	scored	score	VBN
cord-006229-7yoilsho	1239	6	30	30	CD
cord-006229-7yoilsho	1239	7	and	and	CC
cord-006229-7yoilsho	1239	8	150	150	CD
cord-006229-7yoilsho	1239	9	minutes	minute	NNS
cord-006229-7yoilsho	1239	10	after	after	IN
cord-006229-7yoilsho	1239	11	anesthesia	anesthesia	NN
cord-006229-7yoilsho	1239	12	.	.	.
cord-006229-7yoilsho	1240	1	Besides	besides	IN
cord-006229-7yoilsho	1240	2	pain	pain	NN
cord-006229-7yoilsho	1240	3	,	,	,
cord-006229-7yoilsho	1240	4	the	the	DT
cord-006229-7yoilsho	1240	5	grimace	grimace	NN
cord-006229-7yoilsho	1240	6	scale	scale	NN
cord-006229-7yoilsho	1240	7	can	can	MD
cord-006229-7yoilsho	1240	8	also	also	RB
cord-006229-7yoilsho	1240	9	assess	assess	VB
cord-006229-7yoilsho	1240	10	anxiety	anxiety	NN
cord-006229-7yoilsho	1240	11	,	,	,
cord-006229-7yoilsho	1240	12	stress	stress	NN
cord-006229-7yoilsho	1240	13	and	and	CC
cord-006229-7yoilsho	1240	14	malaise	malaise	NN
cord-006229-7yoilsho	1240	15	.	.	.
cord-006229-7yoilsho	1241	1	The	the	DT
cord-006229-7yoilsho	1241	2	display	display	NN
cord-006229-7yoilsho	1241	3	of	of	IN
cord-006229-7yoilsho	1241	4	so	so	RB
cord-006229-7yoilsho	1241	5	-	-	HYPH
cord-006229-7yoilsho	1241	6	called	call	VBN
cord-006229-7yoilsho	1241	7	luxury	luxury	NN
cord-006229-7yoilsho	1241	8	behaviors	behavior	NNS
cord-006229-7yoilsho	1241	9	like	like	IN
cord-006229-7yoilsho	1241	10	nest	nest	NN
cord-006229-7yoilsho	1241	11	building	building	NN
cord-006229-7yoilsho	1241	12	and	and	CC
cord-006229-7yoilsho	1241	13	burrowing	burrow	VBG
cord-006229-7yoilsho	1241	14	behavior	behavior	NN
cord-006229-7yoilsho	1241	15	serves	serve	VBZ
cord-006229-7yoilsho	1241	16	as	as	IN
cord-006229-7yoilsho	1241	17	an	an	DT
cord-006229-7yoilsho	1241	18	indicator	indicator	NN
cord-006229-7yoilsho	1241	19	of	of	IN
cord-006229-7yoilsho	1241	20	wellbeing	wellbeing	NN
cord-006229-7yoilsho	1241	21	.	.	.
cord-006229-7yoilsho	1242	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	1242	2	,	,	,
cord-006229-7yoilsho	1242	3	activity	activity	NN
cord-006229-7yoilsho	1242	4	,	,	,
cord-006229-7yoilsho	1242	5	food	food	NN
cord-006229-7yoilsho	1242	6	and	and	CC
cord-006229-7yoilsho	1242	7	water	water	NN
cord-006229-7yoilsho	1242	8	intake	intake	NN
cord-006229-7yoilsho	1242	9	are	be	VBP
cord-006229-7yoilsho	1242	10	monitored	monitor	VBN
cord-006229-7yoilsho	1242	11	for	for	IN
cord-006229-7yoilsho	1242	12	24	24	CD
cord-006229-7yoilsho	1242	13	hours	hour	NNS
cord-006229-7yoilsho	1242	14	.	.	.
cord-006229-7yoilsho	1243	1	A	a	DT
cord-006229-7yoilsho	1243	2	behavioral	behavioral	JJ
cord-006229-7yoilsho	1243	3	test	test	NN
cord-006229-7yoilsho	1243	4	battery	battery	NN
cord-006229-7yoilsho	1243	5	including	include	VBG
cord-006229-7yoilsho	1243	6	the	the	DT
cord-006229-7yoilsho	1243	7	free	free	JJ
cord-006229-7yoilsho	1243	8	exploratory	exploratory	JJ
cord-006229-7yoilsho	1243	9	paradigm	paradigm	NN
cord-006229-7yoilsho	1243	10	,	,	,
cord-006229-7yoilsho	1243	11	open	open	JJ
cord-006229-7yoilsho	1243	12	field	field	NN
cord-006229-7yoilsho	1243	13	,	,	,
cord-006229-7yoilsho	1243	14	balance	balance	NN
cord-006229-7yoilsho	1243	15	beam	beam	NN
cord-006229-7yoilsho	1243	16	and	and	CC
cord-006229-7yoilsho	1243	17	rota	rota	NN
cord-006229-7yoilsho	1243	18	rod	rod	NN
cord-006229-7yoilsho	1243	19	test	test	NN
cord-006229-7yoilsho	1243	20	is	be	VBZ
cord-006229-7yoilsho	1243	21	performed	perform	VBN
cord-006229-7yoilsho	1243	22	one	one	CD
cord-006229-7yoilsho	1243	23	,	,	,
cord-006229-7yoilsho	1243	24	seven	seven	CD
cord-006229-7yoilsho	1243	25	and	and	CC
cord-006229-7yoilsho	1243	26	ten	ten	CD
cord-006229-7yoilsho	1243	27	days	day	NNS
cord-006229-7yoilsho	1243	28	after	after	IN
cord-006229-7yoilsho	1243	29	the	the	DT
cord-006229-7yoilsho	1243	30	last	last	JJ
cord-006229-7yoilsho	1243	31	anesthesia	anesthesia	NN
cord-006229-7yoilsho	1243	32	.	.	.
cord-006229-7yoilsho	1244	1	Motor	motor	NN
cord-006229-7yoilsho	1244	2	coordination	coordination	NN
cord-006229-7yoilsho	1244	3	and	and	CC
cord-006229-7yoilsho	1244	4	balance	balance	NN
cord-006229-7yoilsho	1244	5	are	be	VBP
cord-006229-7yoilsho	1244	6	assessed	assess	VBN
cord-006229-7yoilsho	1244	7	by	by	IN
cord-006229-7yoilsho	1244	8	the	the	DT
cord-006229-7yoilsho	1244	9	balance	balance	NN
cord-006229-7yoilsho	1244	10	beam	beam	NN
cord-006229-7yoilsho	1244	11	and	and	CC
cord-006229-7yoilsho	1244	12	rota	rota	NN
cord-006229-7yoilsho	1244	13	rod	rod	NN
cord-006229-7yoilsho	1244	14	.	.	.
cord-006229-7yoilsho	1245	1	The	the	DT
cord-006229-7yoilsho	1245	2	open	open	JJ
cord-006229-7yoilsho	1245	3	field	field	NN
cord-006229-7yoilsho	1245	4	is	be	VBZ
cord-006229-7yoilsho	1245	5	a	a	DT
cord-006229-7yoilsho	1245	6	test	test	NN
cord-006229-7yoilsho	1245	7	to	to	TO
cord-006229-7yoilsho	1245	8	investigate	investigate	VB
cord-006229-7yoilsho	1245	9	anxiety	anxiety	NN
cord-006229-7yoilsho	1245	10	-	-	HYPH
cord-006229-7yoilsho	1245	11	related	relate	VBN
cord-006229-7yoilsho	1245	12	and	and	CC
cord-006229-7yoilsho	1245	13	exploratory	exploratory	JJ
cord-006229-7yoilsho	1245	14	behavior	behavior	NN
cord-006229-7yoilsho	1245	15	,	,	,
cord-006229-7yoilsho	1245	16	the	the	DT
cord-006229-7yoilsho	1245	17	free	free	JJ
cord-006229-7yoilsho	1245	18	exploratory	exploratory	JJ
cord-006229-7yoilsho	1245	19	paradigm	paradigm	NN
cord-006229-7yoilsho	1245	20	estimates	estimate	VBZ
cord-006229-7yoilsho	1245	21	trait	trait	NN
cord-006229-7yoilsho	1245	22	anxiety	anxiety	NN
cord-006229-7yoilsho	1245	23	.	.	.
cord-006229-7yoilsho	1246	1	Moreover	moreover	RB
cord-006229-7yoilsho	1246	2	,	,	,
cord-006229-7yoilsho	1246	3	corticosterone	corticosterone	NN
cord-006229-7yoilsho	1246	4	metabolites	metabolite	NNS
cord-006229-7yoilsho	1246	5	are	be	VBP
cord-006229-7yoilsho	1246	6	measured	measure	VBN
cord-006229-7yoilsho	1246	7	in	in	IN
cord-006229-7yoilsho	1246	8	feces	fece	NNS
cord-006229-7yoilsho	1246	9	and	and	CC
cord-006229-7yoilsho	1246	10	fur	fur	NN
cord-006229-7yoilsho	1246	11	in	in	IN
cord-006229-7yoilsho	1246	12	order	order	NN
cord-006229-7yoilsho	1246	13	to	to	TO
cord-006229-7yoilsho	1246	14	prove	prove	VB
cord-006229-7yoilsho	1246	15	evidence	evidence	NN
cord-006229-7yoilsho	1246	16	of	of	IN
cord-006229-7yoilsho	1246	17	cumulative	cumulative	JJ
cord-006229-7yoilsho	1246	18	stress	stress	NN
cord-006229-7yoilsho	1246	19	.	.	.
cord-006229-7yoilsho	1247	1	Results	result	NNS
cord-006229-7yoilsho	1247	2	:	:	:
cord-006229-7yoilsho	1248	1	The	the	DT
cord-006229-7yoilsho	1248	2	first	first	JJ
cord-006229-7yoilsho	1248	3	results	result	NNS
cord-006229-7yoilsho	1248	4	of	of	IN
cord-006229-7yoilsho	1248	5	our	-PRON-	PRP$
cord-006229-7yoilsho	1248	6	study	study	NN
cord-006229-7yoilsho	1248	7	will	will	MD
cord-006229-7yoilsho	1248	8	be	be	VB
cord-006229-7yoilsho	1248	9	presented	present	VBN
cord-006229-7yoilsho	1248	10	at	at	IN
cord-006229-7yoilsho	1248	11	the	the	DT
cord-006229-7yoilsho	1248	12	82	82	CD
cord-006229-7yoilsho	1248	13	nd	nd	NNP
cord-006229-7yoilsho	1248	14	meeting	meeting	NN
cord-006229-7yoilsho	1248	15	of	of	IN
cord-006229-7yoilsho	1248	16	DGPT	DGPT	NNP
cord-006229-7yoilsho	1248	17	.	.	.
cord-006229-7yoilsho	1249	1	Conclusion	conclusion	NN
cord-006229-7yoilsho	1249	2	:	:	:
cord-006229-7yoilsho	1250	1	We	-PRON-	PRP
cord-006229-7yoilsho	1250	2	are	be	VBP
cord-006229-7yoilsho	1250	3	confident	confident	JJ
cord-006229-7yoilsho	1250	4	that	that	IN
cord-006229-7yoilsho	1250	5	the	the	DT
cord-006229-7yoilsho	1250	6	results	result	NNS
cord-006229-7yoilsho	1250	7	of	of	IN
cord-006229-7yoilsho	1250	8	our	-PRON-	PRP$
cord-006229-7yoilsho	1250	9	study	study	NN
cord-006229-7yoilsho	1250	10	will	will	MD
cord-006229-7yoilsho	1250	11	contribute	contribute	VB
cord-006229-7yoilsho	1250	12	to	to	IN
cord-006229-7yoilsho	1250	13	the	the	DT
cord-006229-7yoilsho	1250	14	assessment	assessment	NN
cord-006229-7yoilsho	1250	15	of	of	IN
cord-006229-7yoilsho	1250	16	the	the	DT
cord-006229-7yoilsho	1250	17	severity	severity	NN
cord-006229-7yoilsho	1250	18	level	level	NN
cord-006229-7yoilsho	1250	19	caused	cause	VBN
cord-006229-7yoilsho	1250	20	by	by	IN
cord-006229-7yoilsho	1250	21	multiple	multiple	JJ
cord-006229-7yoilsho	1250	22	exposures	exposure	NNS
cord-006229-7yoilsho	1250	23	to	to	IN
cord-006229-7yoilsho	1250	24	anesthesia	anesthesia	NN
cord-006229-7yoilsho	1250	25	and	and	CC
cord-006229-7yoilsho	1250	26	in	in	IN
cord-006229-7yoilsho	1250	27	this	this	DT
cord-006229-7yoilsho	1250	28	way	way	NN
cord-006229-7yoilsho	1250	29	be	be	VB
cord-006229-7yoilsho	1250	30	a	a	DT
cord-006229-7yoilsho	1250	31	benefit	benefit	NN
cord-006229-7yoilsho	1250	32	for	for	IN
cord-006229-7yoilsho	1250	33	the	the	DT
cord-006229-7yoilsho	1250	34	welfare	welfare	NN
cord-006229-7yoilsho	1250	35	of	of	IN
cord-006229-7yoilsho	1250	36	laboratory	laboratory	NN
cord-006229-7yoilsho	1250	37	rodents	rodent	NNS
cord-006229-7yoilsho	1250	38	.	.	.
cord-006229-7yoilsho	1251	1	BB3R	BB3R	NNP
cord-006229-7yoilsho	1251	2	is	be	VBZ
cord-006229-7yoilsho	1251	3	funded	fund	VBN
cord-006229-7yoilsho	1251	4	by	by	IN
cord-006229-7yoilsho	1251	5	BMBF	BMBF	NNP
cord-006229-7yoilsho	1251	6	.	.	.
cord-006229-7yoilsho	1252	1	In	in	IN
cord-006229-7yoilsho	1252	2	1959	1959	CD
cord-006229-7yoilsho	1252	3	the	the	DT
cord-006229-7yoilsho	1252	4	3R	3R	NNP
cord-006229-7yoilsho	1252	5	-	-	HYPH
cord-006229-7yoilsho	1252	6	principle	principle	NN
cord-006229-7yoilsho	1252	7	was	be	VBD
cord-006229-7yoilsho	1252	8	defined	define	VBN
cord-006229-7yoilsho	1252	9	by	by	IN
cord-006229-7yoilsho	1252	10	the	the	DT
cord-006229-7yoilsho	1252	11	British	british	JJ
cord-006229-7yoilsho	1252	12	scientists	scientist	NNS
cord-006229-7yoilsho	1252	13	William	William	NNP
cord-006229-7yoilsho	1252	14	Russel	Russel	NNP
cord-006229-7yoilsho	1252	15	and	and	CC
cord-006229-7yoilsho	1252	16	Rex	Rex	NNP
cord-006229-7yoilsho	1252	17	Burch	Burch	NNP
cord-006229-7yoilsho	1252	18	in	in	IN
cord-006229-7yoilsho	1252	19	their	-PRON-	PRP$
cord-006229-7yoilsho	1252	20	book	book	NN
cord-006229-7yoilsho	1252	21	'	'	``
cord-006229-7yoilsho	1252	22	The	the	DT
cord-006229-7yoilsho	1252	23	Principles	Principles	NNPS
cord-006229-7yoilsho	1252	24	of	of	IN
cord-006229-7yoilsho	1252	25	Human	Human	NNP
cord-006229-7yoilsho	1252	26	Experimental	Experimental	NNP
cord-006229-7yoilsho	1252	27	Techniques	Techniques	NNPS
cord-006229-7yoilsho	1252	28	'	'	''
cord-006229-7yoilsho	1252	29	.	.	.
cord-006229-7yoilsho	1253	1	The	the	DT
cord-006229-7yoilsho	1253	2	3R	3r	CD
cord-006229-7yoilsho	1253	3	refer	refer	VBP
cord-006229-7yoilsho	1253	4	to	to	IN
cord-006229-7yoilsho	1253	5	Replace	replace	VB
cord-006229-7yoilsho	1253	6	,	,	,
cord-006229-7yoilsho	1253	7	Reduce	reduce	VB
cord-006229-7yoilsho	1253	8	,	,	,
cord-006229-7yoilsho	1253	9	and	and	CC
cord-006229-7yoilsho	1253	10	Refine	refine	VB
cord-006229-7yoilsho	1253	11	.	.	.
cord-006229-7yoilsho	1254	1	They	-PRON-	PRP
cord-006229-7yoilsho	1254	2	set	set	VBD
cord-006229-7yoilsho	1254	3	the	the	DT
cord-006229-7yoilsho	1254	4	goals	goal	NNS
cord-006229-7yoilsho	1254	5	to	to	TO
cord-006229-7yoilsho	1254	6	use	use	VB
cord-006229-7yoilsho	1254	7	alternative	alternative	JJ
cord-006229-7yoilsho	1254	8	non	non	JJ
cord-006229-7yoilsho	1254	9	-	-	JJ
cord-006229-7yoilsho	1254	10	animal	animal	JJ
cord-006229-7yoilsho	1254	11	methods	method	NNS
cord-006229-7yoilsho	1254	12	(	(	-LRB-
cord-006229-7yoilsho	1254	13	Replace	replace	VB
cord-006229-7yoilsho	1254	14	)	)	-RRB-
cord-006229-7yoilsho	1254	15	,	,	,
cord-006229-7yoilsho	1254	16	to	to	TO
cord-006229-7yoilsho	1254	17	reduce	reduce	VB
cord-006229-7yoilsho	1254	18	the	the	DT
cord-006229-7yoilsho	1254	19	number	number	NN
cord-006229-7yoilsho	1254	20	of	of	IN
cord-006229-7yoilsho	1254	21	laboratory	laboratory	NN
cord-006229-7yoilsho	1254	22	animals	animal	NNS
cord-006229-7yoilsho	1254	23	(	(	-LRB-
cord-006229-7yoilsho	1254	24	Reduce	reduce	VB
cord-006229-7yoilsho	1254	25	)	)	-RRB-
cord-006229-7yoilsho	1254	26	and	and	CC
cord-006229-7yoilsho	1254	27	to	to	TO
cord-006229-7yoilsho	1254	28	minimize	minimize	VB
cord-006229-7yoilsho	1254	29	the	the	DT
cord-006229-7yoilsho	1254	30	distress	distress	NN
cord-006229-7yoilsho	1254	31	of	of	IN
cord-006229-7yoilsho	1254	32	laboratory	laboratory	NN
cord-006229-7yoilsho	1254	33	animals	animal	NNS
cord-006229-7yoilsho	1254	34	and	and	CC
cord-006229-7yoilsho	1254	35	to	to	TO
cord-006229-7yoilsho	1254	36	refine	refine	VB
cord-006229-7yoilsho	1254	37	their	-PRON-	PRP$
cord-006229-7yoilsho	1254	38	welfare	welfare	NN
cord-006229-7yoilsho	1254	39	(	(	-LRB-
cord-006229-7yoilsho	1254	40	Refine	refine	VB
cord-006229-7yoilsho	1254	41	)	)	-RRB-
cord-006229-7yoilsho	1254	42	.	.	.
cord-006229-7yoilsho	1255	1	The	the	DT
cord-006229-7yoilsho	1255	2	implementation	implementation	NN
cord-006229-7yoilsho	1255	3	of	of	IN
cord-006229-7yoilsho	1255	4	the	the	DT
cord-006229-7yoilsho	1255	5	3R	3r	NN
cord-006229-7yoilsho	1255	6	-	-	HYPH
cord-006229-7yoilsho	1255	7	concept	concept	NN
cord-006229-7yoilsho	1255	8	is	be	VBZ
cord-006229-7yoilsho	1255	9	the	the	DT
cord-006229-7yoilsho	1255	10	overall	overall	JJ
cord-006229-7yoilsho	1255	11	goal	goal	NN
cord-006229-7yoilsho	1255	12	of	of	IN
cord-006229-7yoilsho	1255	13	scientific	scientific	JJ
cord-006229-7yoilsho	1255	14	animal	animal	NN
cord-006229-7yoilsho	1255	15	welfare	welfare	NN
cord-006229-7yoilsho	1255	16	.	.	.
cord-006229-7yoilsho	1256	1	Article	article	NN
cord-006229-7yoilsho	1256	2	4	4	CD
cord-006229-7yoilsho	1256	3	of	of	IN
cord-006229-7yoilsho	1256	4	the	the	DT
cord-006229-7yoilsho	1256	5	'	'	``
cord-006229-7yoilsho	1256	6	Directive	Directive	NNP
cord-006229-7yoilsho	1256	7	2010/63	2010/63	CD
cord-006229-7yoilsho	1256	8	/	/	SYM
cord-006229-7yoilsho	1256	9	EU	EU	NNP
cord-006229-7yoilsho	1256	10	on	on	IN
cord-006229-7yoilsho	1256	11	the	the	DT
cord-006229-7yoilsho	1256	12	protection	protection	NN
cord-006229-7yoilsho	1256	13	of	of	IN
cord-006229-7yoilsho	1256	14	animals	animal	NNS
cord-006229-7yoilsho	1256	15	used	use	VBN
cord-006229-7yoilsho	1256	16	for	for	IN
cord-006229-7yoilsho	1256	17	scientific	scientific	JJ
cord-006229-7yoilsho	1256	18	purposes	purpose	NNS
cord-006229-7yoilsho	1256	19	'	'	POS
cord-006229-7yoilsho	1256	20	state	state	NN
cord-006229-7yoilsho	1256	21	that	that	IN
cord-006229-7yoilsho	1256	22	the	the	DT
cord-006229-7yoilsho	1256	23	research	research	NN
cord-006229-7yoilsho	1256	24	on	on	IN
cord-006229-7yoilsho	1256	25	Refinement	Refinement	NNP
cord-006229-7yoilsho	1256	26	is	be	VBZ
cord-006229-7yoilsho	1256	27	as	as	RB
cord-006229-7yoilsho	1256	28	important	important	JJ
cord-006229-7yoilsho	1256	29	as	as	IN
cord-006229-7yoilsho	1256	30	on	on	IN
cord-006229-7yoilsho	1256	31	Replacement	Replacement	NNP
cord-006229-7yoilsho	1256	32	and	and	CC
cord-006229-7yoilsho	1256	33	Reduction	Reduction	NNP
cord-006229-7yoilsho	1256	34	[	[	-LRB-
cord-006229-7yoilsho	1256	35	1	1	CD
cord-006229-7yoilsho	1256	36	]	]	-RRB-
cord-006229-7yoilsho	1256	37	.	.	.
cord-006229-7yoilsho	1257	1	According	accord	VBG
cord-006229-7yoilsho	1257	2	to	to	IN
cord-006229-7yoilsho	1257	3	the	the	DT
cord-006229-7yoilsho	1257	4	current	current	JJ
cord-006229-7yoilsho	1257	5	statistics	statistic	NNS
cord-006229-7yoilsho	1257	6	on	on	IN
cord-006229-7yoilsho	1257	7	laboratory	laboratory	NN
cord-006229-7yoilsho	1257	8	animals	animal	NNS
cord-006229-7yoilsho	1257	9	,	,	,
cord-006229-7yoilsho	1257	10	the	the	DT
cord-006229-7yoilsho	1257	11	mouse	mouse	NN
cord-006229-7yoilsho	1257	12	is	be	VBZ
cord-006229-7yoilsho	1257	13	the	the	DT
cord-006229-7yoilsho	1257	14	most	most	RBS
cord-006229-7yoilsho	1257	15	commonly	commonly	RB
cord-006229-7yoilsho	1257	16	used	use	VBN
cord-006229-7yoilsho	1257	17	animal	animal	NN
cord-006229-7yoilsho	1257	18	in	in	IN
cord-006229-7yoilsho	1257	19	experiments	experiment	NNS
cord-006229-7yoilsho	1257	20	with	with	IN
cord-006229-7yoilsho	1257	21	approximately	approximately	RB
cord-006229-7yoilsho	1257	22	70	70	CD
cord-006229-7yoilsho	1257	23	%	%	NN
cord-006229-7yoilsho	1257	24	[	[	-LRB-
cord-006229-7yoilsho	1257	25	2	2	LS
cord-006229-7yoilsho	1257	26	]	]	-RRB-
cord-006229-7yoilsho	1257	27	[	[	-LRB-
cord-006229-7yoilsho	1257	28	3	3	CD
cord-006229-7yoilsho	1257	29	]	]	-RRB-
cord-006229-7yoilsho	1257	30	.	.	.
cord-006229-7yoilsho	1258	1	Effective	effective	JJ
cord-006229-7yoilsho	1258	2	pain	pain	NN
cord-006229-7yoilsho	1258	3	treatment	treatment	NN
cord-006229-7yoilsho	1258	4	is	be	VBZ
cord-006229-7yoilsho	1258	5	crucial	crucial	JJ
cord-006229-7yoilsho	1258	6	not	not	RB
cord-006229-7yoilsho	1258	7	only	only	RB
cord-006229-7yoilsho	1258	8	for	for	IN
cord-006229-7yoilsho	1258	9	ethical	ethical	JJ
cord-006229-7yoilsho	1258	10	and	and	CC
cord-006229-7yoilsho	1258	11	legal	legal	JJ
cord-006229-7yoilsho	1258	12	considerations	consideration	NNS
cord-006229-7yoilsho	1258	13	but	but	CC
cord-006229-7yoilsho	1258	14	also	also	RB
cord-006229-7yoilsho	1258	15	to	to	TO
cord-006229-7yoilsho	1258	16	achieve	achieve	VB
cord-006229-7yoilsho	1258	17	highquality	highquality	NN
cord-006229-7yoilsho	1258	18	results	result	NNS
cord-006229-7yoilsho	1258	19	[	[	-LRB-
cord-006229-7yoilsho	1258	20	4	4	CD
cord-006229-7yoilsho	1258	21	]	]	-RRB-
cord-006229-7yoilsho	1258	22	.	.	.
cord-006229-7yoilsho	1259	1	Pain	pain	NN
cord-006229-7yoilsho	1259	2	in	in	IN
cord-006229-7yoilsho	1259	3	mice	mice	NN
cord-006229-7yoilsho	1259	4	is	be	VBZ
cord-006229-7yoilsho	1259	5	only	only	RB
cord-006229-7yoilsho	1259	6	obvious	obvious	JJ
cord-006229-7yoilsho	1259	7	if	if	IN
cord-006229-7yoilsho	1259	8	it	-PRON-	PRP
cord-006229-7yoilsho	1259	9	is	be	VBZ
cord-006229-7yoilsho	1259	10	severe	severe	JJ
cord-006229-7yoilsho	1259	11	or	or	CC
cord-006229-7yoilsho	1259	12	acute	acute	JJ
cord-006229-7yoilsho	1259	13	pain	pain	NN
cord-006229-7yoilsho	1259	14	.	.	.
cord-006229-7yoilsho	1260	1	However	however	RB
cord-006229-7yoilsho	1260	2	,	,	,
cord-006229-7yoilsho	1260	3	it	-PRON-	PRP
cord-006229-7yoilsho	1260	4	is	be	VBZ
cord-006229-7yoilsho	1260	5	difficult	difficult	JJ
cord-006229-7yoilsho	1260	6	to	to	TO
cord-006229-7yoilsho	1260	7	identify	identify	VB
cord-006229-7yoilsho	1260	8	slight	slight	JJ
cord-006229-7yoilsho	1260	9	or	or	CC
cord-006229-7yoilsho	1260	10	moderate	moderate	JJ
cord-006229-7yoilsho	1260	11	pain	pain	NN
cord-006229-7yoilsho	1260	12	.	.	.
cord-006229-7yoilsho	1261	1	The	the	DT
cord-006229-7yoilsho	1261	2	determination	determination	NN
cord-006229-7yoilsho	1261	3	of	of	IN
cord-006229-7yoilsho	1261	4	pain	pain	NN
cord-006229-7yoilsho	1261	5	levels	level	NNS
cord-006229-7yoilsho	1261	6	and	and	CC
cord-006229-7yoilsho	1261	7	effective	effective	JJ
cord-006229-7yoilsho	1261	8	dosages	dosage	NNS
cord-006229-7yoilsho	1261	9	of	of	IN
cord-006229-7yoilsho	1261	10	analgesics	analgesic	NNS
cord-006229-7yoilsho	1261	11	is	be	VBZ
cord-006229-7yoilsho	1261	12	therefore	therefore	RB
cord-006229-7yoilsho	1261	13	challenging	challenging	JJ
cord-006229-7yoilsho	1261	14	.	.	.
cord-006229-7yoilsho	1262	1	The	the	DT
cord-006229-7yoilsho	1262	2	most	most	RBS
cord-006229-7yoilsho	1262	3	commonly	commonly	RB
cord-006229-7yoilsho	1262	4	used	use	VBN
cord-006229-7yoilsho	1262	5	analgesics	analgesic	NNS
cord-006229-7yoilsho	1262	6	for	for	IN
cord-006229-7yoilsho	1262	7	postsurgical	postsurgical	JJ
cord-006229-7yoilsho	1262	8	pain	pain	NN
cord-006229-7yoilsho	1262	9	treatment	treatment	NN
cord-006229-7yoilsho	1262	10	in	in	IN
cord-006229-7yoilsho	1262	11	mice	mouse	NNS
cord-006229-7yoilsho	1262	12	are	be	VBP
cord-006229-7yoilsho	1262	13	opioids	opioid	NNS
cord-006229-7yoilsho	1262	14	.	.	.
cord-006229-7yoilsho	1263	1	However	however	RB
cord-006229-7yoilsho	1263	2	,	,	,
cord-006229-7yoilsho	1263	3	the	the	DT
cord-006229-7yoilsho	1263	4	recommendations	recommendation	NNS
cord-006229-7yoilsho	1263	5	for	for	IN
cord-006229-7yoilsho	1263	6	their	-PRON-	PRP$
cord-006229-7yoilsho	1263	7	use	use	NN
cord-006229-7yoilsho	1263	8	show	show	NN
cord-006229-7yoilsho	1263	9	vast	vast	JJ
cord-006229-7yoilsho	1263	10	dosage	dosage	NN
cord-006229-7yoilsho	1263	11	ranges	range	NNS
cord-006229-7yoilsho	1263	12	.	.	.
cord-006229-7yoilsho	1264	1	For	for	IN
cord-006229-7yoilsho	1264	2	example	example	NN
cord-006229-7yoilsho	1264	3	,	,	,
cord-006229-7yoilsho	1264	4	the	the	DT
cord-006229-7yoilsho	1264	5	recommended	recommend	VBN
cord-006229-7yoilsho	1264	6	dose	dose	NN
cord-006229-7yoilsho	1264	7	of	of	IN
cord-006229-7yoilsho	1264	8	buprenorphine	buprenorphine	NN
cord-006229-7yoilsho	1264	9	ranges	range	VBZ
cord-006229-7yoilsho	1264	10	from	from	IN
cord-006229-7yoilsho	1264	11	0.05	0.05	CD
cord-006229-7yoilsho	1264	12	to	to	IN
cord-006229-7yoilsho	1264	13	2.5	2.5	CD
cord-006229-7yoilsho	1264	14	mg	mg	NNP
cord-006229-7yoilsho	1264	15	/	/	SYM
cord-006229-7yoilsho	1264	16	kg	kg	NNS
cord-006229-7yoilsho	1264	17	per	per	IN
cord-006229-7yoilsho	1264	18	bodyweight	bodyweight	NN
cord-006229-7yoilsho	1264	19	[	[	-LRB-
cord-006229-7yoilsho	1264	20	5	5	CD
cord-006229-7yoilsho	1264	21	]	]	-RRB-
cord-006229-7yoilsho	1264	22	[	[	-LRB-
cord-006229-7yoilsho	1264	23	6	6	CD
cord-006229-7yoilsho	1264	24	]	]	-RRB-
cord-006229-7yoilsho	1264	25	[	[	-LRB-
cord-006229-7yoilsho	1264	26	7	7	CD
cord-006229-7yoilsho	1264	27	]	]	-RRB-
cord-006229-7yoilsho	1264	28	depending	depend	VBG
cord-006229-7yoilsho	1264	29	on	on	IN
cord-006229-7yoilsho	1264	30	the	the	DT
cord-006229-7yoilsho	1264	31	pain	pain	NN
cord-006229-7yoilsho	1264	32	model	model	NN
cord-006229-7yoilsho	1264	33	used	use	VBN
cord-006229-7yoilsho	1264	34	.	.	.
cord-006229-7yoilsho	1265	1	Additionally	additionally	RB
cord-006229-7yoilsho	1265	2	,	,	,
cord-006229-7yoilsho	1265	3	putative	putative	JJ
cord-006229-7yoilsho	1265	4	pharmacogenetic	pharmacogenetic	JJ
cord-006229-7yoilsho	1265	5	strain	strain	NN
cord-006229-7yoilsho	1265	6	differences	difference	NNS
cord-006229-7yoilsho	1265	7	have	have	VBP
cord-006229-7yoilsho	1265	8	to	to	TO
cord-006229-7yoilsho	1265	9	be	be	VB
cord-006229-7yoilsho	1265	10	considered	consider	VBN
cord-006229-7yoilsho	1265	11	.	.	.
cord-006229-7yoilsho	1266	1	For	for	IN
cord-006229-7yoilsho	1266	2	example	example	NN
cord-006229-7yoilsho	1266	3	,	,	,
cord-006229-7yoilsho	1266	4	the	the	DT
cord-006229-7yoilsho	1266	5	analgesic	analgesic	JJ
cord-006229-7yoilsho	1266	6	treatment	treatment	NN
cord-006229-7yoilsho	1266	7	with	with	IN
cord-006229-7yoilsho	1266	8	morphine	morphine	NN
cord-006229-7yoilsho	1266	9	shows	show	VBZ
cord-006229-7yoilsho	1266	10	mouse	mouse	NN
cord-006229-7yoilsho	1266	11	strain	strain	VBP
cord-006229-7yoilsho	1266	12	specific	specific	JJ
cord-006229-7yoilsho	1266	13	differences	difference	NNS
cord-006229-7yoilsho	1266	14	in	in	IN
cord-006229-7yoilsho	1266	15	pain	pain	NN
cord-006229-7yoilsho	1266	16	sensitivity	sensitivity	NN
cord-006229-7yoilsho	1266	17	[	[	-LRB-
cord-006229-7yoilsho	1266	18	8	8	CD
cord-006229-7yoilsho	1266	19	]	]	-RRB-
cord-006229-7yoilsho	1266	20	.	.	.
cord-006229-7yoilsho	1267	1	The	the	DT
cord-006229-7yoilsho	1267	2	goal	goal	NN
cord-006229-7yoilsho	1267	3	of	of	IN
cord-006229-7yoilsho	1267	4	the	the	DT
cord-006229-7yoilsho	1267	5	project	project	NN
cord-006229-7yoilsho	1267	6	is	be	VBZ
cord-006229-7yoilsho	1267	7	the	the	DT
cord-006229-7yoilsho	1267	8	refinement	refinement	NN
cord-006229-7yoilsho	1267	9	of	of	IN
cord-006229-7yoilsho	1267	10	the	the	DT
cord-006229-7yoilsho	1267	11	recommendations	recommendation	NNS
cord-006229-7yoilsho	1267	12	for	for	IN
cord-006229-7yoilsho	1267	13	effective	effective	JJ
cord-006229-7yoilsho	1267	14	dosage	dosage	NN
cord-006229-7yoilsho	1267	15	of	of	IN
cord-006229-7yoilsho	1267	16	opioid	opioid	JJ
cord-006229-7yoilsho	1267	17	analgesics	analgesic	NNS
cord-006229-7yoilsho	1267	18	in	in	IN
cord-006229-7yoilsho	1267	19	laboratory	laboratory	NN
cord-006229-7yoilsho	1267	20	animals	animal	NNS
cord-006229-7yoilsho	1267	21	for	for	IN
cord-006229-7yoilsho	1267	22	mouse	mouse	NN
cord-006229-7yoilsho	1267	23	inbred	inbred	JJ
cord-006229-7yoilsho	1267	24	strains	strain	NNS
cord-006229-7yoilsho	1267	25	by	by	IN
cord-006229-7yoilsho	1267	26	incorporating	incorporate	VBG
cord-006229-7yoilsho	1267	27	strain	strain	VB
cord-006229-7yoilsho	1267	28	specific	specific	JJ
cord-006229-7yoilsho	1267	29	differences	difference	NNS
cord-006229-7yoilsho	1267	30	.	.	.
cord-006229-7yoilsho	1268	1	Regarding	regard	VBG
cord-006229-7yoilsho	1268	2	the	the	DT
cord-006229-7yoilsho	1268	3	phenotype	phenotype	NN
cord-006229-7yoilsho	1268	4	,	,	,
cord-006229-7yoilsho	1268	5	we	-PRON-	PRP
cord-006229-7yoilsho	1268	6	want	want	VBP
cord-006229-7yoilsho	1268	7	to	to	TO
cord-006229-7yoilsho	1268	8	identify	identify	VB
cord-006229-7yoilsho	1268	9	a	a	DT
cord-006229-7yoilsho	1268	10	putative	putative	JJ
cord-006229-7yoilsho	1268	11	inbred	inbred	JJ
cord-006229-7yoilsho	1268	12	strain	strain	NN
cord-006229-7yoilsho	1268	13	dependent	dependent	JJ
cord-006229-7yoilsho	1268	14	pain	pain	NN
cord-006229-7yoilsho	1268	15	threshold	threshold	NN
cord-006229-7yoilsho	1268	16	and	and	CC
cord-006229-7yoilsho	1268	17	measure	measure	VB
cord-006229-7yoilsho	1268	18	the	the	DT
cord-006229-7yoilsho	1268	19	drug	drug	NN
cord-006229-7yoilsho	1268	20	level	level	NN
cord-006229-7yoilsho	1268	21	in	in	IN
cord-006229-7yoilsho	1268	22	plasma	plasma	NN
cord-006229-7yoilsho	1268	23	and	and	CC
cord-006229-7yoilsho	1268	24	brain	brain	NN
cord-006229-7yoilsho	1268	25	.	.	.
cord-006229-7yoilsho	1269	1	Additionally	additionally	RB
cord-006229-7yoilsho	1269	2	the	the	DT
cord-006229-7yoilsho	1269	3	metabolic	metabolic	JJ
cord-006229-7yoilsho	1269	4	capacity	capacity	NN
cord-006229-7yoilsho	1269	5	and	and	CC
cord-006229-7yoilsho	1269	6	mRNA	mrna	NN
cord-006229-7yoilsho	1269	7	expression	expression	NN
cord-006229-7yoilsho	1269	8	level	level	NN
cord-006229-7yoilsho	1269	9	will	will	MD
cord-006229-7yoilsho	1269	10	be	be	VB
cord-006229-7yoilsho	1269	11	investigated	investigate	VBN
cord-006229-7yoilsho	1269	12	.	.	.
cord-006229-7yoilsho	1270	1	Genotype	genotype	NN
cord-006229-7yoilsho	1270	2	identification	identification	NN
cord-006229-7yoilsho	1270	3	is	be	VBZ
cord-006229-7yoilsho	1270	4	based	base	VBN
cord-006229-7yoilsho	1270	5	on	on	IN
cord-006229-7yoilsho	1270	6	a	a	DT
cord-006229-7yoilsho	1270	7	Data	Data	NNP
cord-006229-7yoilsho	1270	8	Bank	Bank	NNP
cord-006229-7yoilsho	1270	9	analysis	analysis	NN
cord-006229-7yoilsho	1270	10	used	use	VBN
cord-006229-7yoilsho	1270	11	for	for	IN
cord-006229-7yoilsho	1270	12	correlation	correlation	NN
cord-006229-7yoilsho	1270	13	with	with	IN
cord-006229-7yoilsho	1270	14	phenotypical	phenotypical	JJ
cord-006229-7yoilsho	1270	15	parameters	parameter	NNS
cord-006229-7yoilsho	1270	16	.	.	.
cord-006229-7yoilsho	1271	1	[	[	-LRB-
cord-006229-7yoilsho	1271	2	1	1	CD
cord-006229-7yoilsho	1271	3	]	]	-RRB-
cord-006229-7yoilsho	1271	4	RL	RL	NNP
cord-006229-7yoilsho	1271	5	2010/63	2010/63	CD
cord-006229-7yoilsho	1271	6	/	/	SYM
cord-006229-7yoilsho	1271	7	EU	EU	NNP
cord-006229-7yoilsho	1271	8	.	.	.
cord-006229-7yoilsho	1272	1	[	[	-LRB-
cord-006229-7yoilsho	1272	2	2	2	CD
cord-006229-7yoilsho	1272	3	]	]	-RRB-
cord-006229-7yoilsho	1272	4	BMEL	BMEL	NNP
cord-006229-7yoilsho	1272	5	(	(	-LRB-
cord-006229-7yoilsho	1272	6	2014	2014	CD
cord-006229-7yoilsho	1272	7	)	)	-RRB-
cord-006229-7yoilsho	1272	8	.	.	.
cord-006229-7yoilsho	1273	1	Anzahl	Anzahl	NNP
cord-006229-7yoilsho	1273	2	der	der	NNP
cord-006229-7yoilsho	1273	3	für	für	NNP
cord-006229-7yoilsho	1273	4	Versuche	Versuche	NNP
cord-006229-7yoilsho	1273	5	und	und	IN
cord-006229-7yoilsho	1273	6	andere	andere	JJ
cord-006229-7yoilsho	1273	7	wissenschaftliche	wissenschaftliche	JJ
cord-006229-7yoilsho	1273	8	Zwecke	Zwecke	NNP
cord-006229-7yoilsho	1273	9	verwendeten	verwendeten	VBN
cord-006229-7yoilsho	1273	10	Wirbeltiere	Wirbeltiere	NNP
cord-006229-7yoilsho	1273	11	.	.	.
cord-006229-7yoilsho	1274	1	[	[	-LRB-
cord-006229-7yoilsho	1274	2	3	3	CD
cord-006229-7yoilsho	1274	3	]	]	-RRB-
cord-006229-7yoilsho	1274	4	EU	EU	NNP
cord-006229-7yoilsho	1274	5	COMMISSION	COMMISSION	NNP
cord-006229-7yoilsho	1274	6	(	(	-LRB-
cord-006229-7yoilsho	1274	7	2013	2013	CD
cord-006229-7yoilsho	1274	8	)	)	-RRB-
cord-006229-7yoilsho	1274	9	.	.	.
cord-006229-7yoilsho	1275	1	Seventh	Seventh	NNP
cord-006229-7yoilsho	1275	2	Report	Report	NNP
cord-006229-7yoilsho	1275	3	on	on	IN
cord-006229-7yoilsho	1275	4	the	the	DT
cord-006229-7yoilsho	1275	5	Statistics	Statistics	NNPS
cord-006229-7yoilsho	1275	6	on	on	IN
cord-006229-7yoilsho	1275	7	the	the	DT
cord-006229-7yoilsho	1275	8	Number	Number	NNP
cord-006229-7yoilsho	1275	9	of	of	IN
cord-006229-7yoilsho	1275	10	Animals	Animals	NNPS
cord-006229-7yoilsho	1275	11	used	use	VBN
cord-006229-7yoilsho	1275	12	for	for	IN
cord-006229-7yoilsho	1275	13	Experimental	experimental	JJ
cord-006229-7yoilsho	1275	14	and	and	CC
cord-006229-7yoilsho	1275	15	other	other	JJ
cord-006229-7yoilsho	1275	16	Scientific	Scientific	NNP
cord-006229-7yoilsho	1275	17	Purposes	Purposes	NNPS
cord-006229-7yoilsho	1275	18	in	in	IN
cord-006229-7yoilsho	1275	19	the	the	DT
cord-006229-7yoilsho	1275	20	Member	Member	NNP
cord-006229-7yoilsho	1275	21	States	States	NNP
cord-006229-7yoilsho	1275	22	of	of	IN
cord-006229-7yoilsho	1275	23	the	the	DT
cord-006229-7yoilsho	1275	24	European	European	NNP
cord-006229-7yoilsho	1275	25	Union	Union	NNP
cord-006229-7yoilsho	1275	26	.	.	.
cord-006229-7yoilsho	1276	1	[	[	-LRB-
cord-006229-7yoilsho	1276	2	4	4	CD
cord-006229-7yoilsho	1276	3	]	]	-RRB-
cord-006229-7yoilsho	1276	4	Carbone	Carbone	NNP
cord-006229-7yoilsho	1276	5	L	L	NNP
cord-006229-7yoilsho	1276	6	(	(	-LRB-
cord-006229-7yoilsho	1276	7	2011	2011	CD
cord-006229-7yoilsho	1276	8	)	)	-RRB-
cord-006229-7yoilsho	1276	9	Pain	pain	NN
cord-006229-7yoilsho	1276	10	in	in	IN
cord-006229-7yoilsho	1276	11	laboratory	laboratory	NN
cord-006229-7yoilsho	1276	12	animals	animal	NNS
cord-006229-7yoilsho	1276	13	:	:	:
cord-006229-7yoilsho	1276	14	the	the	DT
cord-006229-7yoilsho	1276	15	ethical	ethical	JJ
cord-006229-7yoilsho	1276	16	and	and	CC
cord-006229-7yoilsho	1276	17	regulatory	regulatory	JJ
cord-006229-7yoilsho	1276	18	imperatives	imperative	NNS
cord-006229-7yoilsho	1276	19	.	.	.
cord-006229-7yoilsho	1277	1	Plos	Plos	NNP
cord-006229-7yoilsho	1277	2	One	one	CD
cord-006229-7yoilsho	1277	3	6	6	CD
cord-006229-7yoilsho	1277	4	,	,	,
cord-006229-7yoilsho	1277	5	e21578	e21578	NNP
cord-006229-7yoilsho	1277	6	.	.	.
cord-006229-7yoilsho	1278	1	[	[	-LRB-
cord-006229-7yoilsho	1278	2	5	5	CD
cord-006229-7yoilsho	1278	3	]	]	-RRB-
cord-006229-7yoilsho	1278	4	GV	GV	NNP
cord-006229-7yoilsho	1278	5	-	-	HYPH
cord-006229-7yoilsho	1278	6	Solas	Solas	NNP
cord-006229-7yoilsho	1278	7	,	,	,
cord-006229-7yoilsho	1278	8	A.f	A.f	NNP
cord-006229-7yoilsho	1278	9	.	.	.
cord-006229-7yoilsho	1279	1	A.d	A.d	NNP
cord-006229-7yoilsho	1279	2	.	.	.
cord-006229-7yoilsho	1280	1	(	(	-LRB-
cord-006229-7yoilsho	1280	2	2013	2013	CD
cord-006229-7yoilsho	1280	3	)	)	-RRB-
cord-006229-7yoilsho	1280	4	.	.	.
cord-006229-7yoilsho	1281	1	Empfehlung	Empfehlung	NNP
cord-006229-7yoilsho	1281	2	zur	zur	NNP
cord-006229-7yoilsho	1281	3	Schmerztherapie	Schmerztherapie	NNP
cord-006229-7yoilsho	1281	4	bei	bei	NNP
cord-006229-7yoilsho	1281	5	Versuchstieren	Versuchstieren	NNP
cord-006229-7yoilsho	1281	6	.	.	.
cord-006229-7yoilsho	1282	1	[	[	-LRB-
cord-006229-7yoilsho	1282	2	6	6	CD
cord-006229-7yoilsho	1282	3	]	]	-RRB-
cord-006229-7yoilsho	1282	4	Carpenter	Carpenter	NNP
cord-006229-7yoilsho	1282	5	,	,	,
cord-006229-7yoilsho	1282	6	J.W.	J.W.	NNP
cord-006229-7yoilsho	1282	7	,	,	,
cord-006229-7yoilsho	1282	8	T.Y.	T.Y.	NNP
cord-006229-7yoilsho	1282	9	Mashima	Mashima	NNP
cord-006229-7yoilsho	1282	10	,	,	,
cord-006229-7yoilsho	1282	11	and	and	CC
cord-006229-7yoilsho	1282	12	D.J.	D.J.	NNP
cord-006229-7yoilsho	1282	13	Rupiper	Rupiper	NNP
cord-006229-7yoilsho	1282	14	(	(	-LRB-
cord-006229-7yoilsho	1282	15	2001	2001	CD
cord-006229-7yoilsho	1282	16	)	)	-RRB-
cord-006229-7yoilsho	1282	17	.	.	.
cord-006229-7yoilsho	1283	1	Exotic	Exotic	NNP
cord-006229-7yoilsho	1283	2	Animal	Animal	NNP
cord-006229-7yoilsho	1283	3	Formulary	Formulary	NNP
cord-006229-7yoilsho	1283	4	,	,	,
cord-006229-7yoilsho	1283	5	2nd	2nd	JJ
cord-006229-7yoilsho	1283	6	edition	edition	NN
cord-006229-7yoilsho	1283	7	,	,	,
cord-006229-7yoilsho	1283	8	W.B.	W.B.	NNP
cord-006229-7yoilsho	1283	9	Saunders	Saunders	NNP
cord-006229-7yoilsho	1283	10	Co.	Co.	NNP
cord-006229-7yoilsho	1283	11	,	,	,
cord-006229-7yoilsho	1283	12	Phila	Phila	NNP
cord-006229-7yoilsho	1283	13	.	.	.
cord-006229-7yoilsho	1284	1	[	[	-LRB-
cord-006229-7yoilsho	1284	2	7	7	CD
cord-006229-7yoilsho	1284	3	]	]	-RRB-
cord-006229-7yoilsho	1284	4	Flecknell	Flecknell	NNP
cord-006229-7yoilsho	1284	5	,	,	,
cord-006229-7yoilsho	1284	6	P.	p.	NN
cord-006229-7yoilsho	1284	7	(	(	-LRB-
cord-006229-7yoilsho	1284	8	1996	1996	CD
cord-006229-7yoilsho	1284	9	)	)	-RRB-
cord-006229-7yoilsho	1284	10	.	.	.
cord-006229-7yoilsho	1285	1	Laboratory	Laboratory	NNP
cord-006229-7yoilsho	1285	2	Animal	Animal	NNP
cord-006229-7yoilsho	1285	3	Anaesthesia	Anaesthesia	NNP
cord-006229-7yoilsho	1285	4	,	,	,
cord-006229-7yoilsho	1285	5	2nd	2nd	JJ
cord-006229-7yoilsho	1285	6	edition	edition	NN
cord-006229-7yoilsho	1285	7	,	,	,
cord-006229-7yoilsho	1285	8	Academic	Academic	NNP
cord-006229-7yoilsho	1285	9	Press	Press	NNP
cord-006229-7yoilsho	1285	10	,	,	,
cord-006229-7yoilsho	1285	11	San	San	NNP
cord-006229-7yoilsho	1285	12	Diego	Diego	NNP
cord-006229-7yoilsho	1285	13	,	,	,
cord-006229-7yoilsho	1285	14	CA	CA	NNP
cord-006229-7yoilsho	1285	15	.	.	.
cord-006229-7yoilsho	1286	1	Introduction	introduction	NN
cord-006229-7yoilsho	1286	2	:	:	:
cord-006229-7yoilsho	1287	1	Göttingen	Göttingen	NNP
cord-006229-7yoilsho	1287	2	Minipigs	Minipigs	NNP
cord-006229-7yoilsho	1287	3	™	™	NN
cord-006229-7yoilsho	1287	4	are	be	VBP
cord-006229-7yoilsho	1287	5	frequently	frequently	RB
cord-006229-7yoilsho	1287	6	used	use	VBN
cord-006229-7yoilsho	1287	7	large	large	JJ
cord-006229-7yoilsho	1287	8	animal	animal	NN
cord-006229-7yoilsho	1287	9	models	model	NNS
cord-006229-7yoilsho	1287	10	for	for	IN
cord-006229-7yoilsho	1287	11	orofacial	orofacial	JJ
cord-006229-7yoilsho	1287	12	research	research	NN
cord-006229-7yoilsho	1287	13	,	,	,
cord-006229-7yoilsho	1287	14	for	for	IN
cord-006229-7yoilsho	1287	15	example	example	NN
cord-006229-7yoilsho	1287	16	dental	dental	JJ
cord-006229-7yoilsho	1287	17	implant	implant	JJ
cord-006229-7yoilsho	1287	18	surgery	surgery	NN
cord-006229-7yoilsho	1287	19	.	.	.
cord-006229-7yoilsho	1288	1	Requests	request	NNS
cord-006229-7yoilsho	1288	2	from	from	IN
cord-006229-7yoilsho	1288	3	experimental	experimental	JJ
cord-006229-7yoilsho	1288	4	surgeons	surgeon	NNS
cord-006229-7yoilsho	1288	5	for	for	IN
cord-006229-7yoilsho	1288	6	detailed	detailed	JJ
cord-006229-7yoilsho	1288	7	anatomical	anatomical	JJ
cord-006229-7yoilsho	1288	8	information	information	NN
cord-006229-7yoilsho	1288	9	can	can	MD
cord-006229-7yoilsho	1288	10	not	not	RB
cord-006229-7yoilsho	1288	11	be	be	VB
cord-006229-7yoilsho	1288	12	answered	answer	VBN
cord-006229-7yoilsho	1288	13	because	because	IN
cord-006229-7yoilsho	1288	14	there	there	EX
cord-006229-7yoilsho	1288	15	is	be	VBZ
cord-006229-7yoilsho	1288	16	no	no	DT
cord-006229-7yoilsho	1288	17	existing	exist	VBG
cord-006229-7yoilsho	1288	18	data	datum	NNS
cord-006229-7yoilsho	1288	19	,	,	,
cord-006229-7yoilsho	1288	20	especially	especially	RB
cord-006229-7yoilsho	1288	21	not	not	RB
cord-006229-7yoilsho	1288	22	age	age	NN
cord-006229-7yoilsho	1288	23	-	-	HYPH
cord-006229-7yoilsho	1288	24	related	relate	VBN
cord-006229-7yoilsho	1288	25	.	.	.
cord-006229-7yoilsho	1289	1	Because	because	IN
cord-006229-7yoilsho	1289	2	of	of	IN
cord-006229-7yoilsho	1289	3	unavailable	unavailable	JJ
cord-006229-7yoilsho	1289	4	data	datum	NNS
cord-006229-7yoilsho	1289	5	and	and	CC
cord-006229-7yoilsho	1289	6	the	the	DT
cord-006229-7yoilsho	1289	7	false	false	JJ
cord-006229-7yoilsho	1289	8	choice	choice	NN
cord-006229-7yoilsho	1289	9	of	of	IN
cord-006229-7yoilsho	1289	10	animal	animal	NN
cord-006229-7yoilsho	1289	11	age	age	NN
cord-006229-7yoilsho	1289	12	,	,	,
cord-006229-7yoilsho	1289	13	surgical	surgical	JJ
cord-006229-7yoilsho	1289	14	interventions	intervention	NNS
cord-006229-7yoilsho	1289	15	fail	fail	VBP
cord-006229-7yoilsho	1289	16	or	or	CC
cord-006229-7yoilsho	1289	17	lead	lead	VBP
cord-006229-7yoilsho	1289	18	to	to	IN
cord-006229-7yoilsho	1289	19	enormous	enormous	JJ
cord-006229-7yoilsho	1289	20	post	post	JJ
cord-006229-7yoilsho	1289	21	-	-	JJ
cord-006229-7yoilsho	1289	22	operative	operative	JJ
cord-006229-7yoilsho	1289	23	suffering	suffering	NN
cord-006229-7yoilsho	1289	24	.	.	.
cord-006229-7yoilsho	1290	1	Therefore	therefore	RB
cord-006229-7yoilsho	1290	2	the	the	DT
cord-006229-7yoilsho	1290	3	aim	aim	NN
cord-006229-7yoilsho	1290	4	of	of	IN
cord-006229-7yoilsho	1290	5	this	this	DT
cord-006229-7yoilsho	1290	6	study	study	NN
cord-006229-7yoilsho	1290	7	is	be	VBZ
cord-006229-7yoilsho	1290	8	the	the	DT
cord-006229-7yoilsho	1290	9	acquisition	acquisition	NN
cord-006229-7yoilsho	1290	10	of	of	IN
cord-006229-7yoilsho	1290	11	detailed	detailed	JJ
cord-006229-7yoilsho	1290	12	anatomical	anatomical	JJ
cord-006229-7yoilsho	1290	13	data	datum	NNS
cord-006229-7yoilsho	1290	14	of	of	IN
cord-006229-7yoilsho	1290	15	the	the	DT
cord-006229-7yoilsho	1290	16	mandibula	mandibula	NN
cord-006229-7yoilsho	1290	17	and	and	CC
cord-006229-7yoilsho	1290	18	other	other	JJ
cord-006229-7yoilsho	1290	19	organs	organ	NNS
cord-006229-7yoilsho	1290	20	and	and	CC
cord-006229-7yoilsho	1290	21	structures	structure	NNS
cord-006229-7yoilsho	1290	22	without	without	IN
cord-006229-7yoilsho	1290	23	sacrificing	sacrifice	VBG
cord-006229-7yoilsho	1290	24	pigs	pig	NNS
cord-006229-7yoilsho	1290	25	for	for	IN
cord-006229-7yoilsho	1290	26	this	this	DT
cord-006229-7yoilsho	1290	27	reason	reason	NN
cord-006229-7yoilsho	1290	28	.	.	.
cord-006229-7yoilsho	1291	1	Animals	animal	NNS
cord-006229-7yoilsho	1291	2	,	,	,
cord-006229-7yoilsho	1291	3	materials	material	NNS
cord-006229-7yoilsho	1291	4	and	and	CC
cord-006229-7yoilsho	1291	5	methods	method	NNS
cord-006229-7yoilsho	1291	6	:	:	:
cord-006229-7yoilsho	1291	7	CT	CT	NNP
cord-006229-7yoilsho	1291	8	scans	scan	NNS
cord-006229-7yoilsho	1291	9	of	of	IN
cord-006229-7yoilsho	1291	10	a	a	DT
cord-006229-7yoilsho	1291	11	64-slice	64-slice	CD
cord-006229-7yoilsho	1291	12	scanner	scanner	NN
cord-006229-7yoilsho	1291	13	were	be	VBD
cord-006229-7yoilsho	1291	14	collected	collect	VBN
cord-006229-7yoilsho	1291	15	from	from	IN
cord-006229-7yoilsho	1291	16	18	18	CD
cord-006229-7yoilsho	1291	17	female	female	JJ
cord-006229-7yoilsho	1291	18	minipigs	minipig	NNS
cord-006229-7yoilsho	1291	19	,	,	,
cord-006229-7yoilsho	1291	20	consisting	consist	VBG
cord-006229-7yoilsho	1291	21	of	of	IN
cord-006229-7yoilsho	1291	22	6	6	CD
cord-006229-7yoilsho	1291	23	animals	animal	NNS
cord-006229-7yoilsho	1291	24	aged	age	VBN
cord-006229-7yoilsho	1291	25	12	12	CD
cord-006229-7yoilsho	1291	26	months	month	NNS
cord-006229-7yoilsho	1291	27	(	(	-LRB-
cord-006229-7yoilsho	1291	28	group	group	NN
cord-006229-7yoilsho	1291	29	1	1	CD
cord-006229-7yoilsho	1291	30	,	,	,
cord-006229-7yoilsho	1291	31	n=6	n=6	JJ
cord-006229-7yoilsho	1291	32	)	)	-RRB-
cord-006229-7yoilsho	1291	33	and	and	CC
cord-006229-7yoilsho	1291	34	12	12	CD
cord-006229-7yoilsho	1291	35	animals	animal	NNS
cord-006229-7yoilsho	1291	36	(	(	-LRB-
cord-006229-7yoilsho	1291	37	group	group	NN
cord-006229-7yoilsho	1291	38	2	2	CD
cord-006229-7yoilsho	1291	39	;	;	:
cord-006229-7yoilsho	1291	40	n=12	n=12	NNP
cord-006229-7yoilsho	1291	41	)	)	-RRB-
cord-006229-7yoilsho	1291	42	examined	examine	VBN
cord-006229-7yoilsho	1291	43	at	at	IN
cord-006229-7yoilsho	1291	44	the	the	DT
cord-006229-7yoilsho	1291	45	age	age	NN
cord-006229-7yoilsho	1291	46	of	of	IN
cord-006229-7yoilsho	1291	47	17	17	CD
cord-006229-7yoilsho	1291	48	and	and	CC
cord-006229-7yoilsho	1291	49	21	21	CD
cord-006229-7yoilsho	1291	50	months	month	NNS
cord-006229-7yoilsho	1291	51	.	.	.
cord-006229-7yoilsho	1292	1	These	these	DT
cord-006229-7yoilsho	1292	2	minipigs	minipig	NNS
cord-006229-7yoilsho	1292	3	were	be	VBD
cord-006229-7yoilsho	1292	4	involved	involve	VBN
cord-006229-7yoilsho	1292	5	in	in	IN
cord-006229-7yoilsho	1292	6	experiments	experiment	NNS
cord-006229-7yoilsho	1292	7	,	,	,
cord-006229-7yoilsho	1292	8	approved	approve	VBN
cord-006229-7yoilsho	1292	9	by	by	IN
cord-006229-7yoilsho	1292	10	the	the	DT
cord-006229-7yoilsho	1292	11	Regional	Regional	NNP
cord-006229-7yoilsho	1292	12	Office	Office	NNP
cord-006229-7yoilsho	1292	13	for	for	IN
cord-006229-7yoilsho	1292	14	Health	Health	NNP
cord-006229-7yoilsho	1292	15	and	and	CC
cord-006229-7yoilsho	1292	16	Social	Social	NNP
cord-006229-7yoilsho	1292	17	affairs	affair	NNS
cord-006229-7yoilsho	1292	18	,	,	,
cord-006229-7yoilsho	1292	19	Berlin	Berlin	NNP
cord-006229-7yoilsho	1292	20	.	.	.
cord-006229-7yoilsho	1293	1	Image	image	NN
cord-006229-7yoilsho	1293	2	analysis	analysis	NN
cord-006229-7yoilsho	1293	3	was	be	VBD
cord-006229-7yoilsho	1293	4	performed	perform	VBN
cord-006229-7yoilsho	1293	5	using	use	VBG
cord-006229-7yoilsho	1293	6	Vitrea	Vitrea	NNP
cord-006229-7yoilsho	1293	7	Advanced	Advanced	NNP
cord-006229-7yoilsho	1293	8	®	®	,
cord-006229-7yoilsho	1293	9	(	(	-LRB-
cord-006229-7yoilsho	1293	10	Vital	vital	JJ
cord-006229-7yoilsho	1293	11	images	image	NNS
cord-006229-7yoilsho	1293	12	)	)	-RRB-
cord-006229-7yoilsho	1293	13	.	.	.
cord-006229-7yoilsho	1294	1	More	More	JJR
cord-006229-7yoilsho	1294	2	than	than	IN
cord-006229-7yoilsho	1294	3	50	50	CD
cord-006229-7yoilsho	1294	4	parameters	parameter	NNS
cord-006229-7yoilsho	1294	5	concerning	concern	VBG
cord-006229-7yoilsho	1294	6	teeth	tooth	NNS
cord-006229-7yoilsho	1294	7	,	,	,
cord-006229-7yoilsho	1294	8	the	the	DT
cord-006229-7yoilsho	1294	9	mandibular	mandibular	JJ
cord-006229-7yoilsho	1294	10	body	body	NN
cord-006229-7yoilsho	1294	11	,	,	,
cord-006229-7yoilsho	1294	12	frame	frame	NN
cord-006229-7yoilsho	1294	13	and	and	CC
cord-006229-7yoilsho	1294	14	canal	canal	NN
cord-006229-7yoilsho	1294	15	,	,	,
cord-006229-7yoilsho	1294	16	coronoid	coronoid	NN
cord-006229-7yoilsho	1294	17	process	process	NN
cord-006229-7yoilsho	1294	18	and	and	CC
cord-006229-7yoilsho	1294	19	mandibular	mandibular	JJ
cord-006229-7yoilsho	1294	20	condyle	condyle	NN
cord-006229-7yoilsho	1294	21	were	be	VBD
cord-006229-7yoilsho	1294	22	defined	define	VBN
cord-006229-7yoilsho	1294	23	and	and	CC
cord-006229-7yoilsho	1294	24	measured	measure	VBN
cord-006229-7yoilsho	1294	25	.	.	.
cord-006229-7yoilsho	1295	1	For	for	IN
cord-006229-7yoilsho	1295	2	now	now	RB
cord-006229-7yoilsho	1295	3	,	,	,
cord-006229-7yoilsho	1295	4	we	-PRON-	PRP
cord-006229-7yoilsho	1295	5	focused	focus	VBD
cord-006229-7yoilsho	1295	6	on	on	IN
cord-006229-7yoilsho	1295	7	the	the	DT
cord-006229-7yoilsho	1295	8	development	development	NN
cord-006229-7yoilsho	1295	9	of	of	IN
cord-006229-7yoilsho	1295	10	the	the	DT
cord-006229-7yoilsho	1295	11	mandibular	mandibular	NNP
cord-006229-7yoilsho	1295	12	canal	canal	NN
cord-006229-7yoilsho	1295	13	and	and	CC
cord-006229-7yoilsho	1295	14	the	the	DT
cord-006229-7yoilsho	1295	15	distance	distance	NN
cord-006229-7yoilsho	1295	16	between	between	IN
cord-006229-7yoilsho	1295	17	the	the	DT
cord-006229-7yoilsho	1295	18	dorsal	dorsal	JJ
cord-006229-7yoilsho	1295	19	borders	border	NNS
cord-006229-7yoilsho	1295	20	of	of	IN
cord-006229-7yoilsho	1295	21	the	the	DT
cord-006229-7yoilsho	1295	22	mandibular	mandibular	JJ
cord-006229-7yoilsho	1295	23	canal	canal	NN
cord-006229-7yoilsho	1295	24	to	to	IN
cord-006229-7yoilsho	1295	25	the	the	DT
cord-006229-7yoilsho	1295	26	alveolar	alveolar	JJ
cord-006229-7yoilsho	1295	27	ridge	ridge	NN
cord-006229-7yoilsho	1295	28	at	at	IN
cord-006229-7yoilsho	1295	29	the	the	DT
cord-006229-7yoilsho	1295	30	most	most	RBS
cord-006229-7yoilsho	1295	31	posterior	posterior	JJ
cord-006229-7yoilsho	1295	32	mental	mental	JJ
cord-006229-7yoilsho	1295	33	foramen	foramen	NN
cord-006229-7yoilsho	1295	34	,	,	,
cord-006229-7yoilsho	1295	35	parameters	parameter	VBZ
cord-006229-7yoilsho	1295	36	immensely	immensely	RB
cord-006229-7yoilsho	1295	37	important	important	JJ
cord-006229-7yoilsho	1295	38	for	for	IN
cord-006229-7yoilsho	1295	39	planning	plan	VBG
cord-006229-7yoilsho	1295	40	interventions	intervention	NNS
cord-006229-7yoilsho	1295	41	when	when	WRB
cord-006229-7yoilsho	1295	42	testing	test	VBG
cord-006229-7yoilsho	1295	43	new	new	JJ
cord-006229-7yoilsho	1295	44	dental	dental	JJ
cord-006229-7yoilsho	1295	45	implants	implant	NNS
cord-006229-7yoilsho	1295	46	.	.	.
cord-006229-7yoilsho	1296	1	Results	result	NNS
cord-006229-7yoilsho	1296	2	:	:	:
cord-006229-7yoilsho	1297	1	The	the	DT
cord-006229-7yoilsho	1297	2	measurements	measurement	NNS
cord-006229-7yoilsho	1297	3	by	by	IN
cord-006229-7yoilsho	1297	4	Computed	compute	VBN
cord-006229-7yoilsho	1297	5	tomography	tomography	NN
cord-006229-7yoilsho	1297	6	showed	show	VBD
cord-006229-7yoilsho	1297	7	variations	variation	NNS
cord-006229-7yoilsho	1297	8	of	of	IN
cord-006229-7yoilsho	1297	9	several	several	JJ
cord-006229-7yoilsho	1297	10	parameters	parameter	NNS
cord-006229-7yoilsho	1297	11	between	between	IN
cord-006229-7yoilsho	1297	12	left	left	JJ
cord-006229-7yoilsho	1297	13	and	and	CC
cord-006229-7yoilsho	1297	14	right	right	NNP
cord-006229-7yoilsho	1297	15	ramus	ramus	NNP
cord-006229-7yoilsho	1297	16	mandibulae	mandibulae	NNP
cord-006229-7yoilsho	1297	17	and	and	CC
cord-006229-7yoilsho	1297	18	within	within	IN
cord-006229-7yoilsho	1297	19	the	the	DT
cord-006229-7yoilsho	1297	20	different	different	JJ
cord-006229-7yoilsho	1297	21	age	age	NN
cord-006229-7yoilsho	1297	22	groups	group	NNS
cord-006229-7yoilsho	1297	23	.	.	.
cord-006229-7yoilsho	1298	1	The	the	DT
cord-006229-7yoilsho	1298	2	volume	volume	NN
cord-006229-7yoilsho	1298	3	of	of	IN
cord-006229-7yoilsho	1298	4	the	the	DT
cord-006229-7yoilsho	1298	5	Canalis	Canalis	NNP
cord-006229-7yoilsho	1298	6	mandibulae	mandibulae	NN
cord-006229-7yoilsho	1298	7	increases	increase	VBZ
cord-006229-7yoilsho	1298	8	in	in	IN
cord-006229-7yoilsho	1298	9	time	time	NN
cord-006229-7yoilsho	1298	10	.	.	.
cord-006229-7yoilsho	1299	1	Animals	animal	NNS
cord-006229-7yoilsho	1299	2	of	of	IN
cord-006229-7yoilsho	1299	3	the	the	DT
cord-006229-7yoilsho	1299	4	same	same	JJ
cord-006229-7yoilsho	1299	5	age	age	NN
cord-006229-7yoilsho	1299	6	show	show	VBP
cord-006229-7yoilsho	1299	7	significant	significant	JJ
cord-006229-7yoilsho	1299	8	differences	difference	NNS
cord-006229-7yoilsho	1299	9	in	in	IN
cord-006229-7yoilsho	1299	10	volume	volume	NN
cord-006229-7yoilsho	1299	11	,	,	,
cord-006229-7yoilsho	1299	12	with	with	IN
cord-006229-7yoilsho	1299	13	a	a	DT
cord-006229-7yoilsho	1299	14	range	range	NN
cord-006229-7yoilsho	1299	15	of	of	IN
cord-006229-7yoilsho	1299	16	up	up	IN
cord-006229-7yoilsho	1299	17	to	to	TO
cord-006229-7yoilsho	1299	18	65	65	CD
cord-006229-7yoilsho	1299	19	%	%	NN
cord-006229-7yoilsho	1299	20	where	where	WRB
cord-006229-7yoilsho	1299	21	the	the	DT
cord-006229-7yoilsho	1299	22	largest	large	JJS
cord-006229-7yoilsho	1299	23	volume	volume	NN
cord-006229-7yoilsho	1299	24	was	be	VBD
cord-006229-7yoilsho	1299	25	13,4	13,4	CD
cord-006229-7yoilsho	1299	26	ml	ml	NNS
cord-006229-7yoilsho	1299	27	and	and	CC
cord-006229-7yoilsho	1299	28	the	the	DT
cord-006229-7yoilsho	1299	29	lowest	low	JJS
cord-006229-7yoilsho	1299	30	4,7	4,7	CD
cord-006229-7yoilsho	1299	31	ml	ml	NN
cord-006229-7yoilsho	1299	32	.	.	.
cord-006229-7yoilsho	1300	1	The	the	DT
cord-006229-7yoilsho	1300	2	distance	distance	NN
cord-006229-7yoilsho	1300	3	between	between	IN
cord-006229-7yoilsho	1300	4	the	the	DT
cord-006229-7yoilsho	1300	5	dorsal	dorsal	JJ
cord-006229-7yoilsho	1300	6	borders	border	NNS
cord-006229-7yoilsho	1300	7	of	of	IN
cord-006229-7yoilsho	1300	8	the	the	DT
cord-006229-7yoilsho	1300	9	mandibular	mandibular	JJ
cord-006229-7yoilsho	1300	10	canal	canal	NN
cord-006229-7yoilsho	1300	11	to	to	IN
cord-006229-7yoilsho	1300	12	the	the	DT
cord-006229-7yoilsho	1300	13	alveolar	alveolar	JJ
cord-006229-7yoilsho	1300	14	ridge	ridge	NN
cord-006229-7yoilsho	1300	15	decreases	decrease	VBZ
cord-006229-7yoilsho	1300	16	between	between	IN
cord-006229-7yoilsho	1300	17	12	12	CD
cord-006229-7yoilsho	1300	18	and	and	CC
cord-006229-7yoilsho	1300	19	17	17	CD
cord-006229-7yoilsho	1300	20	months	month	NNS
cord-006229-7yoilsho	1300	21	of	of	IN
cord-006229-7yoilsho	1300	22	age	age	NN
cord-006229-7yoilsho	1300	23	.	.	.
cord-006229-7yoilsho	1301	1	Comparing	compare	VBG
cord-006229-7yoilsho	1301	2	17	17	CD
cord-006229-7yoilsho	1301	3	and	and	CC
cord-006229-7yoilsho	1301	4	21	21	CD
cord-006229-7yoilsho	1301	5	months	month	NNS
cord-006229-7yoilsho	1301	6	old	old	JJ
cord-006229-7yoilsho	1301	7	minipigs	minipigs	NNP
cord-006229-7yoilsho	1301	8	,	,	,
cord-006229-7yoilsho	1301	9	no	no	DT
cord-006229-7yoilsho	1301	10	significant	significant	JJ
cord-006229-7yoilsho	1301	11	difference	difference	NN
cord-006229-7yoilsho	1301	12	in	in	IN
cord-006229-7yoilsho	1301	13	distance	distance	NN
cord-006229-7yoilsho	1301	14	could	could	MD
cord-006229-7yoilsho	1301	15	be	be	VB
cord-006229-7yoilsho	1301	16	observed	observe	VBN
cord-006229-7yoilsho	1301	17	.	.	.
cord-006229-7yoilsho	1302	1	From	from	IN
cord-006229-7yoilsho	1302	2	the	the	DT
cord-006229-7yoilsho	1302	3	age	age	NN
cord-006229-7yoilsho	1302	4	of	of	IN
cord-006229-7yoilsho	1302	5	17	17	CD
cord-006229-7yoilsho	1302	6	months	month	NNS
cord-006229-7yoilsho	1302	7	the	the	DT
cord-006229-7yoilsho	1302	8	position	position	NN
cord-006229-7yoilsho	1302	9	of	of	IN
cord-006229-7yoilsho	1302	10	the	the	DT
cord-006229-7yoilsho	1302	11	mandibular	mandibular	JJ
cord-006229-7yoilsho	1302	12	canal	canal	NN
cord-006229-7yoilsho	1302	13	in	in	IN
cord-006229-7yoilsho	1302	14	relation	relation	NN
cord-006229-7yoilsho	1302	15	to	to	IN
cord-006229-7yoilsho	1302	16	the	the	DT
cord-006229-7yoilsho	1302	17	alveolar	alveolar	JJ
cord-006229-7yoilsho	1302	18	ridge	ridge	NN
cord-006229-7yoilsho	1302	19	remains	remain	VBZ
cord-006229-7yoilsho	1302	20	constant	constant	JJ
cord-006229-7yoilsho	1302	21	.	.	.
cord-006229-7yoilsho	1303	1	Conclusion	conclusion	NN
cord-006229-7yoilsho	1303	2	:	:	:
cord-006229-7yoilsho	1304	1	The	the	DT
cord-006229-7yoilsho	1304	2	decrease	decrease	NN
cord-006229-7yoilsho	1304	3	of	of	IN
cord-006229-7yoilsho	1304	4	the	the	DT
cord-006229-7yoilsho	1304	5	distance	distance	NN
cord-006229-7yoilsho	1304	6	between	between	IN
cord-006229-7yoilsho	1304	7	the	the	DT
cord-006229-7yoilsho	1304	8	mandibular	mandibular	JJ
cord-006229-7yoilsho	1304	9	canal	canal	NN
cord-006229-7yoilsho	1304	10	and	and	CC
cord-006229-7yoilsho	1304	11	the	the	DT
cord-006229-7yoilsho	1304	12	alveolar	alveolar	JJ
cord-006229-7yoilsho	1304	13	ridge	ridge	NN
cord-006229-7yoilsho	1304	14	between	between	IN
cord-006229-7yoilsho	1304	15	12	12	CD
cord-006229-7yoilsho	1304	16	and	and	CC
cord-006229-7yoilsho	1304	17	17	17	CD
cord-006229-7yoilsho	1304	18	months	month	NNS
cord-006229-7yoilsho	1304	19	of	of	IN
cord-006229-7yoilsho	1304	20	age	age	NN
cord-006229-7yoilsho	1304	21	indicates	indicate	VBZ
cord-006229-7yoilsho	1304	22	ongoing	ongoing	JJ
cord-006229-7yoilsho	1304	23	anatomical	anatomical	JJ
cord-006229-7yoilsho	1304	24	changes	change	NNS
cord-006229-7yoilsho	1304	25	of	of	IN
cord-006229-7yoilsho	1304	26	this	this	DT
cord-006229-7yoilsho	1304	27	parameter	parameter	NN
cord-006229-7yoilsho	1304	28	until	until	IN
cord-006229-7yoilsho	1304	29	the	the	DT
cord-006229-7yoilsho	1304	30	age	age	NN
cord-006229-7yoilsho	1304	31	of	of	IN
cord-006229-7yoilsho	1304	32	17	17	CD
cord-006229-7yoilsho	1304	33	months	month	NNS
cord-006229-7yoilsho	1304	34	.	.	.
cord-006229-7yoilsho	1305	1	Therefore	therefore	RB
cord-006229-7yoilsho	1305	2	animals	animal	NNS
cord-006229-7yoilsho	1305	3	should	should	MD
cord-006229-7yoilsho	1305	4	be	be	VB
cord-006229-7yoilsho	1305	5	older	old	JJR
cord-006229-7yoilsho	1305	6	than	than	IN
cord-006229-7yoilsho	1305	7	17	17	CD
cord-006229-7yoilsho	1305	8	months	month	NNS
cord-006229-7yoilsho	1305	9	if	if	IN
cord-006229-7yoilsho	1305	10	included	include	VBN
cord-006229-7yoilsho	1305	11	in	in	IN
cord-006229-7yoilsho	1305	12	long	long	JJ
cord-006229-7yoilsho	1305	13	-	-	HYPH
cord-006229-7yoilsho	1305	14	term	term	NN
cord-006229-7yoilsho	1305	15	studies	study	NNS
cord-006229-7yoilsho	1305	16	after	after	IN
cord-006229-7yoilsho	1305	17	orofacial	orofacial	JJ
cord-006229-7yoilsho	1305	18	experiments	experiment	NNS
cord-006229-7yoilsho	1305	19	,	,	,
cord-006229-7yoilsho	1305	20	like	like	IN
cord-006229-7yoilsho	1305	21	implant	implant	JJ
cord-006229-7yoilsho	1305	22	surgery	surgery	NN
cord-006229-7yoilsho	1305	23	of	of	IN
cord-006229-7yoilsho	1305	24	the	the	DT
cord-006229-7yoilsho	1305	25	mandibula	mandibula	NN
cord-006229-7yoilsho	1305	26	.	.	.
cord-006229-7yoilsho	1306	1	Because	because	IN
cord-006229-7yoilsho	1306	2	of	of	IN
cord-006229-7yoilsho	1306	3	the	the	DT
cord-006229-7yoilsho	1306	4	described	describe	VBN
cord-006229-7yoilsho	1306	5	individual	individual	JJ
cord-006229-7yoilsho	1306	6	differences	difference	NNS
cord-006229-7yoilsho	1306	7	,	,	,
cord-006229-7yoilsho	1306	8	the	the	DT
cord-006229-7yoilsho	1306	9	authors	author	NNS
cord-006229-7yoilsho	1306	10	strongly	strongly	RB
cord-006229-7yoilsho	1306	11	suggest	suggest	VBP
cord-006229-7yoilsho	1306	12	to	to	TO
cord-006229-7yoilsho	1306	13	support	support	VB
cord-006229-7yoilsho	1306	14	the	the	DT
cord-006229-7yoilsho	1306	15	planning	planning	NN
cord-006229-7yoilsho	1306	16	of	of	IN
cord-006229-7yoilsho	1306	17	orofacial	orofacial	JJ
cord-006229-7yoilsho	1306	18	interventions	intervention	NNS
cord-006229-7yoilsho	1306	19	by	by	IN
cord-006229-7yoilsho	1306	20	CT	CT	NNP
cord-006229-7yoilsho	1306	21	imaging	imaging	NN
cord-006229-7yoilsho	1306	22	or	or	CC
cord-006229-7yoilsho	1306	23	other	other	JJ
cord-006229-7yoilsho	1306	24	radiographic	radiographic	JJ
cord-006229-7yoilsho	1306	25	techniques	technique	NNS
cord-006229-7yoilsho	1306	26	.	.	.
cord-006229-7yoilsho	1307	1	Background	background	NN
cord-006229-7yoilsho	1307	2	:	:	:
cord-006229-7yoilsho	1308	1	Laboratory	laboratory	NN
cord-006229-7yoilsho	1308	2	housing	housing	NN
cord-006229-7yoilsho	1308	3	conditions	condition	NNS
cord-006229-7yoilsho	1308	4	are	be	VBP
cord-006229-7yoilsho	1308	5	standardized	standardize	VBN
cord-006229-7yoilsho	1308	6	to	to	IN
cord-006229-7yoilsho	1308	7	a	a	DT
cord-006229-7yoilsho	1308	8	high	high	JJ
cord-006229-7yoilsho	1308	9	level	level	NN
cord-006229-7yoilsho	1308	10	.	.	.
cord-006229-7yoilsho	1309	1	Under	under	IN
cord-006229-7yoilsho	1309	2	these	these	DT
cord-006229-7yoilsho	1309	3	conditions	condition	NNS
cord-006229-7yoilsho	1309	4	,	,	,
cord-006229-7yoilsho	1309	5	the	the	DT
cord-006229-7yoilsho	1309	6	occurrence	occurrence	NN
cord-006229-7yoilsho	1309	7	of	of	IN
cord-006229-7yoilsho	1309	8	stereotypic	stereotypic	JJ
cord-006229-7yoilsho	1309	9	behaviour	behaviour	NN
cord-006229-7yoilsho	1309	10	(	(	-LRB-
cord-006229-7yoilsho	1309	11	SB	SB	NNP
cord-006229-7yoilsho	1309	12	)	)	-RRB-
cord-006229-7yoilsho	1309	13	can	can	MD
cord-006229-7yoilsho	1309	14	be	be	VB
cord-006229-7yoilsho	1309	15	observed	observe	VBN
cord-006229-7yoilsho	1309	16	.	.	.
cord-006229-7yoilsho	1310	1	Stereotypies	stereotypie	NNS
cord-006229-7yoilsho	1310	2	are	be	VBP
cord-006229-7yoilsho	1310	3	commonly	commonly	RB
cord-006229-7yoilsho	1310	4	known	know	VBN
cord-006229-7yoilsho	1310	5	as	as	IN
cord-006229-7yoilsho	1310	6	deviations	deviation	NNS
cord-006229-7yoilsho	1310	7	from	from	IN
cord-006229-7yoilsho	1310	8	normal	normal	JJ
cord-006229-7yoilsho	1310	9	behaviour	behaviour	NN
cord-006229-7yoilsho	1310	10	that	that	WDT
cord-006229-7yoilsho	1310	11	are	be	VBP
cord-006229-7yoilsho	1310	12	repetitive	repetitive	JJ
cord-006229-7yoilsho	1310	13	,	,	,
cord-006229-7yoilsho	1310	14	invariant	invariant	JJ
cord-006229-7yoilsho	1310	15	and	and	CC
cord-006229-7yoilsho	1310	16	without	without	IN
cord-006229-7yoilsho	1310	17	any	any	DT
cord-006229-7yoilsho	1310	18	obvious	obvious	JJ
cord-006229-7yoilsho	1310	19	function	function	NN
cord-006229-7yoilsho	1310	20	or	or	CC
cord-006229-7yoilsho	1310	21	aim	aim	VB
cord-006229-7yoilsho	1310	22	for	for	IN
cord-006229-7yoilsho	1310	23	the	the	DT
cord-006229-7yoilsho	1310	24	animal	animal	NN
cord-006229-7yoilsho	1310	25	[	[	-LRB-
cord-006229-7yoilsho	1310	26	1	1	CD
cord-006229-7yoilsho	1310	27	]	]	-RRB-
cord-006229-7yoilsho	1310	28	.	.	.
cord-006229-7yoilsho	1311	1	Worldwide	worldwide	RB
cord-006229-7yoilsho	1311	2	it	-PRON-	PRP
cord-006229-7yoilsho	1311	3	is	be	VBZ
cord-006229-7yoilsho	1311	4	estimated	estimate	VBN
cord-006229-7yoilsho	1311	5	that	that	IN
cord-006229-7yoilsho	1311	6	over	over	IN
cord-006229-7yoilsho	1311	7	85	85	CD
cord-006229-7yoilsho	1311	8	million	million	CD
cord-006229-7yoilsho	1311	9	animals	animal	NNS
cord-006229-7yoilsho	1311	10	perform	perform	VBP
cord-006229-7yoilsho	1311	11	SB	SB	NNP
cord-006229-7yoilsho	1311	12	,	,	,
cord-006229-7yoilsho	1311	13	with	with	IN
cord-006229-7yoilsho	1311	14	the	the	DT
cord-006229-7yoilsho	1311	15	highest	high	JJS
cord-006229-7yoilsho	1311	16	prevalence	prevalence	NN
cord-006229-7yoilsho	1311	17	in	in	IN
cord-006229-7yoilsho	1311	18	laboratory	laboratory	NN
cord-006229-7yoilsho	1311	19	animals	animal	NNS
cord-006229-7yoilsho	1311	20	and	and	CC
cord-006229-7yoilsho	1311	21	the	the	DT
cord-006229-7yoilsho	1311	22	agricultural	agricultural	JJ
cord-006229-7yoilsho	1311	23	sector	sector	NN
cord-006229-7yoilsho	1311	24	.	.	.
cord-006229-7yoilsho	1312	1	FVB	FVB	NNP
cord-006229-7yoilsho	1312	2	/	/	SYM
cord-006229-7yoilsho	1312	3	N	N	NNP
cord-006229-7yoilsho	1312	4	is	be	VBZ
cord-006229-7yoilsho	1312	5	a	a	DT
cord-006229-7yoilsho	1312	6	typical	typical	JJ
cord-006229-7yoilsho	1312	7	inbred	inbred	JJ
cord-006229-7yoilsho	1312	8	mouse	mouse	NN
cord-006229-7yoilsho	1312	9	-	-	HYPH
cord-006229-7yoilsho	1312	10	strain	strain	NN
cord-006229-7yoilsho	1312	11	that	that	WDT
cord-006229-7yoilsho	1312	12	shows	show	VBZ
cord-006229-7yoilsho	1312	13	different	different	JJ
cord-006229-7yoilsho	1312	14	types	type	NNS
cord-006229-7yoilsho	1312	15	of	of	IN
cord-006229-7yoilsho	1312	16	stereotyped	stereotyped	JJ
cord-006229-7yoilsho	1312	17	movements	movement	NNS
cord-006229-7yoilsho	1312	18	.	.	.
cord-006229-7yoilsho	1313	1	It	-PRON-	PRP
cord-006229-7yoilsho	1313	2	is	be	VBZ
cord-006229-7yoilsho	1313	3	known	know	VBN
cord-006229-7yoilsho	1313	4	that	that	IN
cord-006229-7yoilsho	1313	5	environmental	environmental	JJ
cord-006229-7yoilsho	1313	6	enrichment	enrichment	NN
cord-006229-7yoilsho	1313	7	decreases	decrease	VBZ
cord-006229-7yoilsho	1313	8	the	the	DT
cord-006229-7yoilsho	1313	9	incidence	incidence	NN
cord-006229-7yoilsho	1313	10	of	of	IN
cord-006229-7yoilsho	1313	11	SB	SB	NNP
cord-006229-7yoilsho	1313	12	,	,	,
cord-006229-7yoilsho	1313	13	yet	yet	CC
cord-006229-7yoilsho	1313	14	they	-PRON-	PRP
cord-006229-7yoilsho	1313	15	still	still	RB
cord-006229-7yoilsho	1313	16	occur	occur	VBP
cord-006229-7yoilsho	1313	17	[	[	-LRB-
cord-006229-7yoilsho	1313	18	2	2	CD
cord-006229-7yoilsho	1313	19	]	]	-RRB-
cord-006229-7yoilsho	1313	20	.	.	.
cord-006229-7yoilsho	1314	1	Since	since	IN
cord-006229-7yoilsho	1314	2	animal	animal	NN
cord-006229-7yoilsho	1314	3	's	's	POS
cord-006229-7yoilsho	1314	4	behaviour	behaviour	NN
cord-006229-7yoilsho	1314	5	highly	highly	RB
cord-006229-7yoilsho	1314	6	influences	influence	VBZ
cord-006229-7yoilsho	1314	7	its	-PRON-	PRP$
cord-006229-7yoilsho	1314	8	metabolism	metabolism	NN
cord-006229-7yoilsho	1314	9	and	and	CC
cord-006229-7yoilsho	1314	10	immune	immune	JJ
cord-006229-7yoilsho	1314	11	system	system	NN
cord-006229-7yoilsho	1314	12	,	,	,
cord-006229-7yoilsho	1314	13	differences	difference	NNS
cord-006229-7yoilsho	1314	14	in	in	IN
cord-006229-7yoilsho	1314	15	handling	handling	NN
cord-006229-7yoilsho	1314	16	,	,	,
cord-006229-7yoilsho	1314	17	caring	care	VBG
cord-006229-7yoilsho	1314	18	and	and	CC
cord-006229-7yoilsho	1314	19	keeping	keeping	NN
cord-006229-7yoilsho	1314	20	can	can	MD
cord-006229-7yoilsho	1314	21	lead	lead	VB
cord-006229-7yoilsho	1314	22	to	to	IN
cord-006229-7yoilsho	1314	23	varying	vary	VBG
cord-006229-7yoilsho	1314	24	results	result	NNS
cord-006229-7yoilsho	1314	25	,	,	,
cord-006229-7yoilsho	1314	26	even	even	RB
cord-006229-7yoilsho	1314	27	with	with	IN
cord-006229-7yoilsho	1314	28	an	an	DT
cord-006229-7yoilsho	1314	29	identical	identical	JJ
cord-006229-7yoilsho	1314	30	experimental	experimental	JJ
cord-006229-7yoilsho	1314	31	setup	setup	NN
cord-006229-7yoilsho	1314	32	[	[	-LRB-
cord-006229-7yoilsho	1314	33	3	3	CD
cord-006229-7yoilsho	1314	34	]	]	-RRB-
cord-006229-7yoilsho	1314	35	.	.	.
cord-006229-7yoilsho	1315	1	Aim	aim	VB
cord-006229-7yoilsho	1315	2	:	:	:
cord-006229-7yoilsho	1315	3	of	of	IN
cord-006229-7yoilsho	1315	4	the	the	DT
cord-006229-7yoilsho	1315	5	study	study	NN
cord-006229-7yoilsho	1315	6	Aim	Aim	NNP
cord-006229-7yoilsho	1315	7	of	of	IN
cord-006229-7yoilsho	1315	8	the	the	DT
cord-006229-7yoilsho	1315	9	study	study	NN
cord-006229-7yoilsho	1315	10	is	be	VBZ
cord-006229-7yoilsho	1315	11	to	to	TO
cord-006229-7yoilsho	1315	12	observe	observe	VB
cord-006229-7yoilsho	1315	13	different	different	JJ
cord-006229-7yoilsho	1315	14	life	life	NN
cord-006229-7yoilsho	1315	15	stages	stage	NNS
cord-006229-7yoilsho	1315	16	of	of	IN
cord-006229-7yoilsho	1315	17	FVB	FVB	NNP
cord-006229-7yoilsho	1315	18	/	/	SYM
cord-006229-7yoilsho	1315	19	N	N	NNP
cord-006229-7yoilsho	1315	20	-	-	HYPH
cord-006229-7yoilsho	1315	21	mice	mouse	NNS
cord-006229-7yoilsho	1315	22	and	and	CC
cord-006229-7yoilsho	1315	23	immediately	immediately	RB
cord-006229-7yoilsho	1315	24	detect	detect	VB
cord-006229-7yoilsho	1315	25	the	the	DT
cord-006229-7yoilsho	1315	26	development	development	NN
cord-006229-7yoilsho	1315	27	of	of	IN
cord-006229-7yoilsho	1315	28	SB	SB	NNP
cord-006229-7yoilsho	1315	29	.	.	.
cord-006229-7yoilsho	1316	1	Observations	observation	NNS
cord-006229-7yoilsho	1316	2	are	be	VBP
cord-006229-7yoilsho	1316	3	linked	link	VBN
cord-006229-7yoilsho	1316	4	to	to	IN
cord-006229-7yoilsho	1316	5	various	various	JJ
cord-006229-7yoilsho	1316	6	behavioural	behavioural	JJ
cord-006229-7yoilsho	1316	7	tests	test	NNS
cord-006229-7yoilsho	1316	8	and	and	CC
cord-006229-7yoilsho	1316	9	the	the	DT
cord-006229-7yoilsho	1316	10	characterisation	characterisation	NN
cord-006229-7yoilsho	1316	11	of	of	IN
cord-006229-7yoilsho	1316	12	the	the	DT
cord-006229-7yoilsho	1316	13	metabolic	metabolic	JJ
cord-006229-7yoilsho	1316	14	and	and	CC
cord-006229-7yoilsho	1316	15	immunological	immunological	JJ
cord-006229-7yoilsho	1316	16	phenotype	phenotype	NN
cord-006229-7yoilsho	1316	17	.	.	.
cord-006229-7yoilsho	1317	1	The	the	DT
cord-006229-7yoilsho	1317	2	results	result	NNS
cord-006229-7yoilsho	1317	3	will	will	MD
cord-006229-7yoilsho	1317	4	lead	lead	VB
cord-006229-7yoilsho	1317	5	to	to	IN
cord-006229-7yoilsho	1317	6	a	a	DT
cord-006229-7yoilsho	1317	7	better	well	JJR
cord-006229-7yoilsho	1317	8	understanding	understanding	NN
cord-006229-7yoilsho	1317	9	of	of	IN
cord-006229-7yoilsho	1317	10	the	the	DT
cord-006229-7yoilsho	1317	11	mechanisms	mechanism	NNS
cord-006229-7yoilsho	1317	12	driving	drive	VBG
cord-006229-7yoilsho	1317	13	the	the	DT
cord-006229-7yoilsho	1317	14	development	development	NN
cord-006229-7yoilsho	1317	15	of	of	IN
cord-006229-7yoilsho	1317	16	SB	SB	NNP
cord-006229-7yoilsho	1317	17	and	and	CC
cord-006229-7yoilsho	1317	18	clarify	clarify	VB
cord-006229-7yoilsho	1317	19	its	-PRON-	PRP$
cord-006229-7yoilsho	1317	20	implication	implication	NN
cord-006229-7yoilsho	1317	21	to	to	IN
cord-006229-7yoilsho	1317	22	animal	animal	NN
cord-006229-7yoilsho	1317	23	welfare	welfare	NN
cord-006229-7yoilsho	1317	24	or	or	CC
cord-006229-7yoilsho	1317	25	to	to	TO
cord-006229-7yoilsho	1317	26	what	what	WDT
cord-006229-7yoilsho	1317	27	extent	extent	NN
cord-006229-7yoilsho	1317	28	the	the	DT
cord-006229-7yoilsho	1317	29	performance	performance	NN
cord-006229-7yoilsho	1317	30	of	of	IN
cord-006229-7yoilsho	1317	31	stereotypies	stereotypie	NNS
cord-006229-7yoilsho	1317	32	even	even	RB
cord-006229-7yoilsho	1317	33	reflect	reflect	VBP
cord-006229-7yoilsho	1317	34	emotional	emotional	JJ
cord-006229-7yoilsho	1317	35	suffering	suffering	NN
cord-006229-7yoilsho	1317	36	.	.	.
cord-006229-7yoilsho	1318	1	The	the	DT
cord-006229-7yoilsho	1318	2	strain	strain	NN
cord-006229-7yoilsho	1318	3	-	-	HYPH
cord-006229-7yoilsho	1318	4	related	relate	VBN
cord-006229-7yoilsho	1318	5	behaviour	behaviour	NN
cord-006229-7yoilsho	1318	6	and	and	CC
cord-006229-7yoilsho	1318	7	SB	SB	NNP
cord-006229-7yoilsho	1318	8	are	be	VBP
cord-006229-7yoilsho	1318	9	recorded	record	VBN
cord-006229-7yoilsho	1318	10	with	with	IN
cord-006229-7yoilsho	1318	11	computer	computer	NN
cord-006229-7yoilsho	1318	12	-	-	HYPH
cord-006229-7yoilsho	1318	13	assisted	assist	VBN
cord-006229-7yoilsho	1318	14	programmes	programme	NNS
cord-006229-7yoilsho	1318	15	.	.	.
cord-006229-7yoilsho	1319	1	Observational	observational	JJ
cord-006229-7yoilsho	1319	2	periods	period	NNS
cord-006229-7yoilsho	1319	3	already	already	RB
cord-006229-7yoilsho	1319	4	begin	begin	VBP
cord-006229-7yoilsho	1319	5	with	with	IN
cord-006229-7yoilsho	1319	6	the	the	DT
cord-006229-7yoilsho	1319	7	parental	parental	JJ
cord-006229-7yoilsho	1319	8	generation	generation	NN
cord-006229-7yoilsho	1319	9	.	.	.
cord-006229-7yoilsho	1320	1	As	as	IN
cord-006229-7yoilsho	1320	2	possible	possible	JJ
cord-006229-7yoilsho	1320	3	indicators	indicator	NNS
cord-006229-7yoilsho	1320	4	for	for	IN
cord-006229-7yoilsho	1320	5	later	later	RB
cord-006229-7yoilsho	1320	6	developing	develop	VBG
cord-006229-7yoilsho	1320	7	SB	SB	NNP
cord-006229-7yoilsho	1320	8	,	,	,
cord-006229-7yoilsho	1320	9	data	datum	NNS
cord-006229-7yoilsho	1320	10	on	on	IN
cord-006229-7yoilsho	1320	11	reproductive	reproductive	JJ
cord-006229-7yoilsho	1320	12	success	success	NN
cord-006229-7yoilsho	1320	13	and	and	CC
cord-006229-7yoilsho	1320	14	maternal	maternal	JJ
cord-006229-7yoilsho	1320	15	care	care	NN
cord-006229-7yoilsho	1320	16	are	be	VBP
cord-006229-7yoilsho	1320	17	collected	collect	VBN
cord-006229-7yoilsho	1320	18	,	,	,
cord-006229-7yoilsho	1320	19	such	such	JJ
cord-006229-7yoilsho	1320	20	as	as	IN
cord-006229-7yoilsho	1320	21	different	different	JJ
cord-006229-7yoilsho	1320	22	behavioural	behavioural	JJ
cord-006229-7yoilsho	1320	23	tests	test	NNS
cord-006229-7yoilsho	1320	24	.	.	.
cord-006229-7yoilsho	1321	1	The	the	DT
cord-006229-7yoilsho	1321	2	animals	animal	NNS
cord-006229-7yoilsho	1321	3	are	be	VBP
cord-006229-7yoilsho	1321	4	characterized	characterize	VBN
cord-006229-7yoilsho	1321	5	by	by	IN
cord-006229-7yoilsho	1321	6	a	a	DT
cord-006229-7yoilsho	1321	7	specific	specific	JJ
cord-006229-7yoilsho	1321	8	protocol	protocol	NN
cord-006229-7yoilsho	1321	9	for	for	IN
cord-006229-7yoilsho	1321	10	detecting	detect	VBG
cord-006229-7yoilsho	1321	11	the	the	DT
cord-006229-7yoilsho	1321	12	metabolic	metabolic	JJ
cord-006229-7yoilsho	1321	13	and	and	CC
cord-006229-7yoilsho	1321	14	immunological	immunological	JJ
cord-006229-7yoilsho	1321	15	phenotype	phenotype	NN
cord-006229-7yoilsho	1321	16	.	.	.
cord-006229-7yoilsho	1322	1	Finally	finally	RB
cord-006229-7yoilsho	1322	2	,	,	,
cord-006229-7yoilsho	1322	3	histological	histological	JJ
cord-006229-7yoilsho	1322	4	and	and	CC
cord-006229-7yoilsho	1322	5	molecular	molecular	JJ
cord-006229-7yoilsho	1322	6	biological	biological	JJ
cord-006229-7yoilsho	1322	7	analyses	analysis	NNS
cord-006229-7yoilsho	1322	8	follow	follow	VBP
cord-006229-7yoilsho	1322	9	.	.	.
cord-006229-7yoilsho	1323	1	Outlook	outlook	NN
cord-006229-7yoilsho	1323	2	:	:	:
cord-006229-7yoilsho	1323	3	It	-PRON-	PRP
cord-006229-7yoilsho	1323	4	is	be	VBZ
cord-006229-7yoilsho	1323	5	of	of	IN
cord-006229-7yoilsho	1323	6	paramount	paramount	JJ
cord-006229-7yoilsho	1323	7	importance	importance	NN
cord-006229-7yoilsho	1323	8	to	to	TO
cord-006229-7yoilsho	1323	9	take	take	VB
cord-006229-7yoilsho	1323	10	good	good	JJ
cord-006229-7yoilsho	1323	11	care	care	NN
cord-006229-7yoilsho	1323	12	for	for	IN
cord-006229-7yoilsho	1323	13	the	the	DT
cord-006229-7yoilsho	1323	14	welfare	welfare	NN
cord-006229-7yoilsho	1323	15	of	of	IN
cord-006229-7yoilsho	1323	16	laboratory	laboratory	NN
cord-006229-7yoilsho	1323	17	animals	animal	NNS
cord-006229-7yoilsho	1323	18	(	(	-LRB-
cord-006229-7yoilsho	1323	19	3R	3R	NNP
cord-006229-7yoilsho	1323	20	-	-	HYPH
cord-006229-7yoilsho	1323	21	Refinement	Refinement	NNP
cord-006229-7yoilsho	1323	22	)	)	-RRB-
cord-006229-7yoilsho	1323	23	.	.	.
cord-006229-7yoilsho	1324	1	Though	though	RB
cord-006229-7yoilsho	1324	2	,	,	,
cord-006229-7yoilsho	1324	3	the	the	DT
cord-006229-7yoilsho	1324	4	knowledge	knowledge	NN
cord-006229-7yoilsho	1324	5	about	about	IN
cord-006229-7yoilsho	1324	6	the	the	DT
cord-006229-7yoilsho	1324	7	ethological	ethological	JJ
cord-006229-7yoilsho	1324	8	particularities	particularity	NNS
cord-006229-7yoilsho	1324	9	of	of	IN
cord-006229-7yoilsho	1324	10	animals	animal	NNS
cord-006229-7yoilsho	1324	11	and	and	CC
cord-006229-7yoilsho	1324	12	the	the	DT
cord-006229-7yoilsho	1324	13	motivational	motivational	JJ
cord-006229-7yoilsho	1324	14	base	base	NN
cord-006229-7yoilsho	1324	15	of	of	IN
cord-006229-7yoilsho	1324	16	animals	animal	NNS
cord-006229-7yoilsho	1324	17	performing	perform	VBG
cord-006229-7yoilsho	1324	18	SB	SB	NNP
cord-006229-7yoilsho	1324	19	are	be	VBP
cord-006229-7yoilsho	1324	20	not	not	RB
cord-006229-7yoilsho	1324	21	enough	enough	JJ
cord-006229-7yoilsho	1324	22	to	to	TO
cord-006229-7yoilsho	1324	23	generally	generally	RB
cord-006229-7yoilsho	1324	24	avoid	avoid	VB
cord-006229-7yoilsho	1324	25	stereotypies	stereotypie	NNS
cord-006229-7yoilsho	1324	26	.	.	.
cord-006229-7yoilsho	1325	1	Therefore	therefore	RB
cord-006229-7yoilsho	1325	2	the	the	DT
cord-006229-7yoilsho	1325	3	meaning	meaning	NN
cord-006229-7yoilsho	1325	4	according	accord	VBG
cord-006229-7yoilsho	1325	5	to	to	IN
cord-006229-7yoilsho	1325	6	the	the	DT
cord-006229-7yoilsho	1325	7	character	character	NN
cord-006229-7yoilsho	1325	8	of	of	IN
cord-006229-7yoilsho	1325	9	SB	SB	NNP
cord-006229-7yoilsho	1325	10	has	have	VBZ
cord-006229-7yoilsho	1325	11	to	to	TO
cord-006229-7yoilsho	1325	12	be	be	VB
cord-006229-7yoilsho	1325	13	analysed	analyse	VBN
cord-006229-7yoilsho	1325	14	more	more	RBR
cord-006229-7yoilsho	1325	15	intensively	intensively	RB
cord-006229-7yoilsho	1325	16	to	to	TO
cord-006229-7yoilsho	1325	17	understand	understand	VB
cord-006229-7yoilsho	1325	18	the	the	DT
cord-006229-7yoilsho	1325	19	needs	need	NNS
cord-006229-7yoilsho	1325	20	of	of	IN
cord-006229-7yoilsho	1325	21	laboratory	laboratory	NN
cord-006229-7yoilsho	1325	22	animals	animal	NNS
cord-006229-7yoilsho	1325	23	and	and	CC
cord-006229-7yoilsho	1325	24	evolve	evolve	VB
cord-006229-7yoilsho	1325	25	recommendations	recommendation	NNS
cord-006229-7yoilsho	1325	26	for	for	IN
cord-006229-7yoilsho	1325	27	optimizing	optimize	VBG
cord-006229-7yoilsho	1325	28	the	the	DT
cord-006229-7yoilsho	1325	29	breeding	breeding	NN
cord-006229-7yoilsho	1325	30	and	and	CC
cord-006229-7yoilsho	1325	31	keeping	keep	VBG
cord-006229-7yoilsho	1325	32	such	such	JJ
cord-006229-7yoilsho	1325	33	as	as	IN
cord-006229-7yoilsho	1325	34	for	for	IN
cord-006229-7yoilsho	1325	35	the	the	DT
cord-006229-7yoilsho	1325	36	assessment	assessment	NN
cord-006229-7yoilsho	1325	37	of	of	IN
cord-006229-7yoilsho	1325	38	possible	possible	JJ
cord-006229-7yoilsho	1325	39	distress	distress	NN
cord-006229-7yoilsho	1325	40	in	in	IN
cord-006229-7yoilsho	1325	41	animals	animal	NNS
cord-006229-7yoilsho	1325	42	performing	perform	VBG
cord-006229-7yoilsho	1325	43	SB	SB	NNP
cord-006229-7yoilsho	1325	44	.	.	.
cord-006229-7yoilsho	1326	1	Objective	objective	NN
cord-006229-7yoilsho	1326	2	:	:	:
cord-006229-7yoilsho	1327	1	Thermoregulation	thermoregulation	NN
cord-006229-7yoilsho	1327	2	is	be	VBZ
cord-006229-7yoilsho	1327	3	a	a	DT
cord-006229-7yoilsho	1327	4	vital	vital	JJ
cord-006229-7yoilsho	1327	5	function	function	NN
cord-006229-7yoilsho	1327	6	in	in	IN
cord-006229-7yoilsho	1327	7	both	both	DT
cord-006229-7yoilsho	1327	8	humans	human	NNS
cord-006229-7yoilsho	1327	9	and	and	CC
cord-006229-7yoilsho	1327	10	animals	animal	NNS
cord-006229-7yoilsho	1327	11	with	with	IN
cord-006229-7yoilsho	1327	12	the	the	DT
cord-006229-7yoilsho	1327	13	serotonin	serotonin	NN
cord-006229-7yoilsho	1327	14	(	(	-LRB-
cord-006229-7yoilsho	1327	15	5-HT	5-ht	CD
cord-006229-7yoilsho	1327	16	)	)	-RRB-
cord-006229-7yoilsho	1327	17	system	system	NN
cord-006229-7yoilsho	1327	18	,	,	,
cord-006229-7yoilsho	1327	19	in	in	IN
cord-006229-7yoilsho	1327	20	particular	particular	JJ
cord-006229-7yoilsho	1327	21	the	the	DT
cord-006229-7yoilsho	1327	22	5-HT	5-ht	CD
cord-006229-7yoilsho	1327	23	1A	1a	NN
cord-006229-7yoilsho	1327	24	receptor	receptor	NN
cord-006229-7yoilsho	1327	25	,	,	,
cord-006229-7yoilsho	1327	26	playing	play	VBG
cord-006229-7yoilsho	1327	27	a	a	DT
cord-006229-7yoilsho	1327	28	major	major	JJ
cord-006229-7yoilsho	1327	29	role	role	NN
cord-006229-7yoilsho	1327	30	.	.	.
cord-006229-7yoilsho	1328	1	Activating	activate	VBG
cord-006229-7yoilsho	1328	2	5-HT	5-ht	CD
cord-006229-7yoilsho	1328	3	1A	1a	CD
cord-006229-7yoilsho	1328	4	receptors	receptor	NNS
cord-006229-7yoilsho	1328	5	by	by	IN
cord-006229-7yoilsho	1328	6	the	the	DT
cord-006229-7yoilsho	1328	7	5-HT	5-ht	CD
cord-006229-7yoilsho	1328	8	1A	1a	CD
cord-006229-7yoilsho	1328	9	receptor	receptor	NN
cord-006229-7yoilsho	1328	10	agonist	agonist	NN
cord-006229-7yoilsho	1328	11	8-hydroxy-2-(dipropylamino)tetralin	8-hydroxy-2-(dipropylamino)tetralin	CD
cord-006229-7yoilsho	1328	12	(	(	-LRB-
cord-006229-7yoilsho	1328	13	8-OH	8-oh	CD
cord-006229-7yoilsho	1328	14	-	-	HYPH
cord-006229-7yoilsho	1328	15	DPAT	dpat	NN
cord-006229-7yoilsho	1328	16	)	)	-RRB-
cord-006229-7yoilsho	1328	17	leads	lead	VBZ
cord-006229-7yoilsho	1328	18	to	to	IN
cord-006229-7yoilsho	1328	19	reduced	reduce	VBN
cord-006229-7yoilsho	1328	20	body	body	NN
cord-006229-7yoilsho	1328	21	temperature	temperature	NN
cord-006229-7yoilsho	1328	22	.	.	.
cord-006229-7yoilsho	1329	1	While	while	IN
cord-006229-7yoilsho	1329	2	there	there	EX
cord-006229-7yoilsho	1329	3	is	be	VBZ
cord-006229-7yoilsho	1329	4	consensus	consensus	NN
cord-006229-7yoilsho	1329	5	that	that	IN
cord-006229-7yoilsho	1329	6	hypothermia	hypothermia	NN
cord-006229-7yoilsho	1329	7	is	be	VBZ
cord-006229-7yoilsho	1329	8	induced	induce	VBN
cord-006229-7yoilsho	1329	9	by	by	IN
cord-006229-7yoilsho	1329	10	the	the	DT
cord-006229-7yoilsho	1329	11	stimulation	stimulation	NN
cord-006229-7yoilsho	1329	12	of	of	IN
cord-006229-7yoilsho	1329	13	postsynaptic	postsynaptic	JJ
cord-006229-7yoilsho	1329	14	5-HT	5-ht	CD
cord-006229-7yoilsho	1329	15	1A	1a	NN
cord-006229-7yoilsho	1329	16	receptors	receptor	NNS
cord-006229-7yoilsho	1329	17	in	in	IN
cord-006229-7yoilsho	1329	18	rats	rat	NNS
cord-006229-7yoilsho	1329	19	and	and	CC
cord-006229-7yoilsho	1329	20	humans	human	NNS
cord-006229-7yoilsho	1329	21	,	,	,
cord-006229-7yoilsho	1329	22	the	the	DT
cord-006229-7yoilsho	1329	23	regulatory	regulatory	JJ
cord-006229-7yoilsho	1329	24	mechanisms	mechanism	NNS
cord-006229-7yoilsho	1329	25	in	in	IN
cord-006229-7yoilsho	1329	26	mice	mouse	NNS
cord-006229-7yoilsho	1329	27	are	be	VBP
cord-006229-7yoilsho	1329	28	less	less	RBR
cord-006229-7yoilsho	1329	29	clear	clear	JJ
cord-006229-7yoilsho	1329	30	.	.	.
cord-006229-7yoilsho	1330	1	In	in	IN
cord-006229-7yoilsho	1330	2	our	-PRON-	PRP$
cord-006229-7yoilsho	1330	3	group	group	NN
cord-006229-7yoilsho	1330	4	,	,	,
cord-006229-7yoilsho	1330	5	within	within	IN
cord-006229-7yoilsho	1330	6	phenotyping	phenotype	VBG
cord-006229-7yoilsho	1330	7	a	a	DT
cord-006229-7yoilsho	1330	8	transgenic	transgenic	JJ
cord-006229-7yoilsho	1330	9	mouse	mouse	NN
cord-006229-7yoilsho	1330	10	line	line	NN
cord-006229-7yoilsho	1330	11	permanently	permanently	RB
cord-006229-7yoilsho	1330	12	overexpressing	overexpresse	VBG
cord-006229-7yoilsho	1330	13	the	the	DT
cord-006229-7yoilsho	1330	14	5-HT	5-ht	CD
cord-006229-7yoilsho	1330	15	1A	1a	CD
cord-006229-7yoilsho	1330	16	receptor	receptor	NN
cord-006229-7yoilsho	1330	17	in	in	IN
cord-006229-7yoilsho	1330	18	serotonergic	serotonergic	JJ
cord-006229-7yoilsho	1330	19	projection	projection	NN
cord-006229-7yoilsho	1330	20	areas	area	NNS
cord-006229-7yoilsho	1330	21	,	,	,
cord-006229-7yoilsho	1330	22	Bert	Bert	NNP
cord-006229-7yoilsho	1330	23	et	et	NNP
cord-006229-7yoilsho	1330	24	al	al	NNP
cord-006229-7yoilsho	1330	25	.	.	.
cord-006229-7yoilsho	1331	1	(	(	-LRB-
cord-006229-7yoilsho	1331	2	2008	2008	CD
cord-006229-7yoilsho	1331	3	,	,	,
cord-006229-7yoilsho	1331	4	PMID	PMID	NNP
cord-006229-7yoilsho	1331	5	:	:	:
cord-006229-7yoilsho	1331	6	18396339	18396339	CD
cord-006229-7yoilsho	1331	7	)	)	-RRB-
cord-006229-7yoilsho	1331	8	revealed	reveal	VBD
cord-006229-7yoilsho	1331	9	exaggerated	exaggerated	JJ
cord-006229-7yoilsho	1331	10	8-OH	8-oh	CD
cord-006229-7yoilsho	1331	11	-	-	HYPH
cord-006229-7yoilsho	1331	12	DPAT	dpat	NN
cord-006229-7yoilsho	1331	13	-	-	HYPH
cord-006229-7yoilsho	1331	14	provoked	provoke	VBN
cord-006229-7yoilsho	1331	15	hypothermic	hypothermic	JJ
cord-006229-7yoilsho	1331	16	response	response	NN
cord-006229-7yoilsho	1331	17	.	.	.
cord-006229-7yoilsho	1332	1	Thus	thus	RB
cord-006229-7yoilsho	1332	2	,	,	,
cord-006229-7yoilsho	1332	3	the	the	DT
cord-006229-7yoilsho	1332	4	objective	objective	NN
cord-006229-7yoilsho	1332	5	of	of	IN
cord-006229-7yoilsho	1332	6	the	the	DT
cord-006229-7yoilsho	1332	7	present	present	JJ
cord-006229-7yoilsho	1332	8	study	study	NN
cord-006229-7yoilsho	1332	9	was	be	VBD
cord-006229-7yoilsho	1332	10	to	to	TO
cord-006229-7yoilsho	1332	11	substantiate	substantiate	VB
cord-006229-7yoilsho	1332	12	the	the	DT
cord-006229-7yoilsho	1332	13	contribution	contribution	NN
cord-006229-7yoilsho	1332	14	of	of	IN
cord-006229-7yoilsho	1332	15	postsynaptic	postsynaptic	JJ
cord-006229-7yoilsho	1332	16	5-HT	5-ht	CD
cord-006229-7yoilsho	1332	17	1A	1a	NN
cord-006229-7yoilsho	1332	18	receptors	receptor	NNS
cord-006229-7yoilsho	1332	19	to	to	IN
cord-006229-7yoilsho	1332	20	thermoregulation	thermoregulation	NN
cord-006229-7yoilsho	1332	21	,	,	,
cord-006229-7yoilsho	1332	22	more	more	RBR
cord-006229-7yoilsho	1332	23	precisely	precisely	RB
cord-006229-7yoilsho	1332	24	to	to	IN
cord-006229-7yoilsho	1332	25	the	the	DT
cord-006229-7yoilsho	1332	26	hypothermic	hypothermic	JJ
cord-006229-7yoilsho	1332	27	effect	effect	NN
cord-006229-7yoilsho	1332	28	of	of	IN
cord-006229-7yoilsho	1332	29	8-OH	8-oh	CD
cord-006229-7yoilsho	1332	30	-	-	HYPH
cord-006229-7yoilsho	1332	31	DPAT	dpat	NN
cord-006229-7yoilsho	1332	32	,	,	,
cord-006229-7yoilsho	1332	33	in	in	IN
cord-006229-7yoilsho	1332	34	mice	mouse	NNS
cord-006229-7yoilsho	1332	35	.	.	.
cord-006229-7yoilsho	1333	1	Methods	method	NNS
cord-006229-7yoilsho	1333	2	:	:	:
cord-006229-7yoilsho	1333	3	We	-PRON-	PRP
cord-006229-7yoilsho	1333	4	used	use	VBD
cord-006229-7yoilsho	1333	5	radio	radio	NN
cord-006229-7yoilsho	1333	6	telemetry	telemetry	NN
cord-006229-7yoilsho	1333	7	technique	technique	NN
cord-006229-7yoilsho	1333	8	to	to	TO
cord-006229-7yoilsho	1333	9	monitor	monitor	VB
cord-006229-7yoilsho	1333	10	the	the	DT
cord-006229-7yoilsho	1333	11	basal	basal	NN
cord-006229-7yoilsho	1333	12	body	body	NN
cord-006229-7yoilsho	1333	13	temperature	temperature	NN
cord-006229-7yoilsho	1333	14	and	and	CC
cord-006229-7yoilsho	1333	15	the	the	DT
cord-006229-7yoilsho	1333	16	hypothermic	hypothermic	JJ
cord-006229-7yoilsho	1333	17	effect	effect	NN
cord-006229-7yoilsho	1333	18	of	of	IN
cord-006229-7yoilsho	1333	19	different	different	JJ
cord-006229-7yoilsho	1333	20	doses	dose	NNS
cord-006229-7yoilsho	1333	21	of	of	IN
cord-006229-7yoilsho	1333	22	8-OH	8-oh	CD
cord-006229-7yoilsho	1333	23	-	-	HYPH
cord-006229-7yoilsho	1333	24	DPAT	dpat	NN
cord-006229-7yoilsho	1333	25	(	(	-LRB-
cord-006229-7yoilsho	1333	26	0.1	0.1	CD
cord-006229-7yoilsho	1333	27	mg	mg	NNP
cord-006229-7yoilsho	1333	28	/	/	SYM
cord-006229-7yoilsho	1333	29	kg	kg	NNP
cord-006229-7yoilsho	1334	1	-4	-4	NNP
cord-006229-7yoilsho	1335	1	mg	mg	NNP
cord-006229-7yoilsho	1335	2	/	/	SYM
cord-006229-7yoilsho	1335	3	kg	kg	NNP
cord-006229-7yoilsho	1335	4	i.	i.	NN
cord-006229-7yoilsho	1335	5	p.	p.	NN
cord-006229-7yoilsho	1335	6	)	)	-RRB-
cord-006229-7yoilsho	1336	1	in	in	IN
cord-006229-7yoilsho	1336	2	male	male	JJ
cord-006229-7yoilsho	1336	3	transgenic	transgenic	JJ
cord-006229-7yoilsho	1336	4	mice	mouse	NNS
cord-006229-7yoilsho	1336	5	in	in	IN
cord-006229-7yoilsho	1336	6	comparison	comparison	NN
cord-006229-7yoilsho	1336	7	to	to	IN
cord-006229-7yoilsho	1336	8	NMRI	NMRI	NNP
cord-006229-7yoilsho	1336	9	wild	wild	JJ
cord-006229-7yoilsho	1336	10	-	-	HYPH
cord-006229-7yoilsho	1336	11	type	type	NN
cord-006229-7yoilsho	1336	12	males	male	NNS
cord-006229-7yoilsho	1336	13	.	.	.
cord-006229-7yoilsho	1337	1	Additionally	additionally	RB
cord-006229-7yoilsho	1337	2	,	,	,
cord-006229-7yoilsho	1337	3	we	-PRON-	PRP
cord-006229-7yoilsho	1337	4	investigated	investigate	VBD
cord-006229-7yoilsho	1337	5	whether	whether	IN
cord-006229-7yoilsho	1337	6	reduction	reduction	NN
cord-006229-7yoilsho	1337	7	of	of	IN
cord-006229-7yoilsho	1337	8	serotonergic	serotonergic	JJ
cord-006229-7yoilsho	1337	9	activity	activity	NN
cord-006229-7yoilsho	1337	10	by	by	IN
cord-006229-7yoilsho	1337	11	pretreatment	pretreatment	NN
cord-006229-7yoilsho	1337	12	with	with	IN
cord-006229-7yoilsho	1337	13	the	the	DT
cord-006229-7yoilsho	1337	14	5-HT	5-ht	CD
cord-006229-7yoilsho	1337	15	synthesis	synthesis	NN
cord-006229-7yoilsho	1337	16	inhibitor	inhibitor	NN
cord-006229-7yoilsho	1337	17	parachlorophenylalanine	parachlorophenylalanine	NNP
cord-006229-7yoilsho	1337	18	(	(	-LRB-
cord-006229-7yoilsho	1337	19	PCPA	PCPA	NNP
cord-006229-7yoilsho	1337	20	;	;	:
cord-006229-7yoilsho	1337	21	100	100	CD
cord-006229-7yoilsho	1337	22	mg	mg	NNP
cord-006229-7yoilsho	1337	23	/	/	SYM
cord-006229-7yoilsho	1337	24	kg	kg	NNP
cord-006229-7yoilsho	1337	25	,	,	,
cord-006229-7yoilsho	1337	26	i.	i.	NN
cord-006229-7yoilsho	1337	27	p.	p.	NN
cord-006229-7yoilsho	1337	28	on	on	IN
cord-006229-7yoilsho	1337	29	four	four	CD
cord-006229-7yoilsho	1337	30	consecutive	consecutive	JJ
cord-006229-7yoilsho	1337	31	days	day	NNS
cord-006229-7yoilsho	1337	32	)	)	-RRB-
cord-006229-7yoilsho	1337	33	would	would	MD
cord-006229-7yoilsho	1337	34	alter	alter	VB
cord-006229-7yoilsho	1337	35	the	the	DT
cord-006229-7yoilsho	1337	36	effects	effect	NNS
cord-006229-7yoilsho	1337	37	of	of	IN
cord-006229-7yoilsho	1337	38	8-OH	8-oh	CD
cord-006229-7yoilsho	1337	39	-	-	HYPH
cord-006229-7yoilsho	1337	40	DPAT	dpat	NN
cord-006229-7yoilsho	1337	41	on	on	IN
cord-006229-7yoilsho	1337	42	body	body	NN
cord-006229-7yoilsho	1337	43	temperature	temperature	NN
cord-006229-7yoilsho	1337	44	in	in	IN
cord-006229-7yoilsho	1337	45	transgenic	transgenic	JJ
cord-006229-7yoilsho	1337	46	mice	mouse	NNS
cord-006229-7yoilsho	1337	47	postsynaptically	postsynaptically	RB
cord-006229-7yoilsho	1337	48	overexpressing	overexpresse	VBG
cord-006229-7yoilsho	1337	49	the	the	DT
cord-006229-7yoilsho	1337	50	5-HT	5-ht	CD
cord-006229-7yoilsho	1337	51	1A	1a	CD
cord-006229-7yoilsho	1337	52	receptor	receptor	NN
cord-006229-7yoilsho	1337	53	.	.	.
cord-006229-7yoilsho	1338	1	Results	result	NNS
cord-006229-7yoilsho	1338	2	:	:	:
cord-006229-7yoilsho	1338	3	5-HT	5-ht	CD
cord-006229-7yoilsho	1338	4	1A	1a	CD
cord-006229-7yoilsho	1339	1	overexpressing	overexpresse	VBG
cord-006229-7yoilsho	1339	2	mice	mouse	NNS
cord-006229-7yoilsho	1339	3	revealed	reveal	VBD
cord-006229-7yoilsho	1339	4	lower	low	JJR
cord-006229-7yoilsho	1339	5	levels	level	NNS
cord-006229-7yoilsho	1339	6	of	of	IN
cord-006229-7yoilsho	1339	7	basal	basal	NN
cord-006229-7yoilsho	1339	8	body	body	NN
cord-006229-7yoilsho	1339	9	temperature	temperature	NN
cord-006229-7yoilsho	1339	10	than	than	IN
cord-006229-7yoilsho	1339	11	wild	wild	JJ
cord-006229-7yoilsho	1339	12	types	type	NNS
cord-006229-7yoilsho	1339	13	(	(	-LRB-
cord-006229-7yoilsho	1339	14	transgenic	transgenic	JJ
cord-006229-7yoilsho	1339	15	mice	mouse	NNS
cord-006229-7yoilsho	1339	16	:	:	:
cord-006229-7yoilsho	1339	17	36.0	36.0	CD
cord-006229-7yoilsho	1339	18	°	°	NN
cord-006229-7yoilsho	1339	19	C	c	NN
cord-006229-7yoilsho	1339	20	;	;	:
cord-006229-7yoilsho	1339	21	NMRI	NMRI	NNP
cord-006229-7yoilsho	1339	22	wild	wild	JJ
cord-006229-7yoilsho	1339	23	-	-	HYPH
cord-006229-7yoilsho	1339	24	type	type	NN
cord-006229-7yoilsho	1339	25	mice	mouse	NNS
cord-006229-7yoilsho	1339	26	:	:	:
cord-006229-7yoilsho	1339	27	37.4	37.4	CD
cord-006229-7yoilsho	1339	28	°	°	NN
cord-006229-7yoilsho	1339	29	C	C	NNP
cord-006229-7yoilsho	1339	30	)	)	-RRB-
cord-006229-7yoilsho	1339	31	.	.	.
cord-006229-7yoilsho	1340	1	In	in	IN
cord-006229-7yoilsho	1340	2	both	both	DT
cord-006229-7yoilsho	1340	3	genotypes	genotype	NNS
cord-006229-7yoilsho	1340	4	,	,	,
cord-006229-7yoilsho	1340	5	systemic	systemic	JJ
cord-006229-7yoilsho	1340	6	administration	administration	NN
cord-006229-7yoilsho	1340	7	of	of	IN
cord-006229-7yoilsho	1340	8	8-OH	8-oh	CD
cord-006229-7yoilsho	1340	9	-	-	HYPH
cord-006229-7yoilsho	1340	10	DPAT	dpat	NN
cord-006229-7yoilsho	1340	11	dose	dose	NN
cord-006229-7yoilsho	1340	12	-	-	HYPH
cord-006229-7yoilsho	1340	13	dependently	dependently	RB
cord-006229-7yoilsho	1340	14	decreased	decrease	VBN
cord-006229-7yoilsho	1340	15	body	body	NN
cord-006229-7yoilsho	1340	16	temperature	temperature	NN
cord-006229-7yoilsho	1340	17	,	,	,
cord-006229-7yoilsho	1340	18	being	be	VBG
cord-006229-7yoilsho	1340	19	significantly	significantly	RB
cord-006229-7yoilsho	1340	20	more	more	RBR
cord-006229-7yoilsho	1340	21	pronounced	pronounced	JJ
cord-006229-7yoilsho	1340	22	in	in	IN
cord-006229-7yoilsho	1340	23	mutant	mutant	JJ
cord-006229-7yoilsho	1340	24	mice	mouse	NNS
cord-006229-7yoilsho	1340	25	(	(	-LRB-
cord-006229-7yoilsho	1340	26	-2.8	-2.8	NNP
cord-006229-7yoilsho	1340	27	°	°	NN
cord-006229-7yoilsho	1340	28	C	c	NN
cord-006229-7yoilsho	1340	29	compared	compare	VBN
cord-006229-7yoilsho	1340	30	to	to	IN
cord-006229-7yoilsho	1340	31	-1.5	-1.5	NN
cord-006229-7yoilsho	1340	32	°	°	NN
cord-006229-7yoilsho	1340	33	C	c	NN
cord-006229-7yoilsho	1340	34	in	in	IN
cord-006229-7yoilsho	1340	35	NMRI	NMRI	NNP
cord-006229-7yoilsho	1340	36	wild	wild	JJ
cord-006229-7yoilsho	1340	37	types	type	NNS
cord-006229-7yoilsho	1340	38	)	)	-RRB-
cord-006229-7yoilsho	1340	39	.	.	.
cord-006229-7yoilsho	1341	1	Dose	dose	JJ
cord-006229-7yoilsho	1341	2	response	response	NN
cord-006229-7yoilsho	1341	3	curves	curve	NNS
cord-006229-7yoilsho	1341	4	of	of	IN
cord-006229-7yoilsho	1341	5	8-OH	8-oh	CD
cord-006229-7yoilsho	1341	6	-	-	HYPH
cord-006229-7yoilsho	1341	7	DPAT	DPAT	NNP
cord-006229-7yoilsho	1341	8	revealed	reveal	VBD
cord-006229-7yoilsho	1341	9	an	an	DT
cord-006229-7yoilsho	1341	10	ED	ED	NNP
cord-006229-7yoilsho	1341	11	50	50	CD
cord-006229-7yoilsho	1341	12	=	=	SYM
cord-006229-7yoilsho	1341	13	0.4	0.4	CD
cord-006229-7yoilsho	1341	14	mg	mg	NNP
cord-006229-7yoilsho	1341	15	/	/	SYM
cord-006229-7yoilsho	1341	16	kg	kg	NNS
cord-006229-7yoilsho	1341	17	in	in	IN
cord-006229-7yoilsho	1341	18	transgenic	transgenic	NN
cord-006229-7yoilsho	1341	19	and	and	CC
cord-006229-7yoilsho	1341	20	an	an	DT
cord-006229-7yoilsho	1341	21	ED	ED	NNP
cord-006229-7yoilsho	1341	22	50	50	CD
cord-006229-7yoilsho	1341	23	=	=	SYM
cord-006229-7yoilsho	1341	24	0.57	0.57	CD
cord-006229-7yoilsho	1341	25	mg	mg	NNP
cord-006229-7yoilsho	1341	26	/	/	SYM
cord-006229-7yoilsho	1341	27	kg	kg	NNS
cord-006229-7yoilsho	1341	28	in	in	IN
cord-006229-7yoilsho	1341	29	NMRI	NMRI	NNP
cord-006229-7yoilsho	1341	30	wild	wild	JJ
cord-006229-7yoilsho	1341	31	-	-	HYPH
cord-006229-7yoilsho	1341	32	type	type	NN
cord-006229-7yoilsho	1341	33	mice	mouse	NNS
cord-006229-7yoilsho	1341	34	.	.	.
cord-006229-7yoilsho	1342	1	PCPA	PCPA	NNP
cord-006229-7yoilsho	1342	2	pretreatment	pretreatment	NN
cord-006229-7yoilsho	1342	3	did	do	VBD
cord-006229-7yoilsho	1342	4	not	not	RB
cord-006229-7yoilsho	1342	5	alter	alter	VB
cord-006229-7yoilsho	1342	6	the	the	DT
cord-006229-7yoilsho	1342	7	hypothermic	hypothermic	JJ
cord-006229-7yoilsho	1342	8	response	response	NN
cord-006229-7yoilsho	1342	9	to	to	IN
cord-006229-7yoilsho	1342	10	8-OH	8-oh	CD
cord-006229-7yoilsho	1342	11	-	-	HYPH
cord-006229-7yoilsho	1342	12	DPAT	dpat	NN
cord-006229-7yoilsho	1342	13	in	in	IN
cord-006229-7yoilsho	1342	14	mice	mouse	NNS
cord-006229-7yoilsho	1342	15	.	.	.
cord-006229-7yoilsho	1343	1	The	the	DT
cord-006229-7yoilsho	1343	2	dose	dose	JJ
cord-006229-7yoilsho	1343	3	-	-	HYPH
cord-006229-7yoilsho	1343	4	response	response	NN
cord-006229-7yoilsho	1343	5	curves	curve	NNS
cord-006229-7yoilsho	1343	6	indicate	indicate	VBP
cord-006229-7yoilsho	1343	7	a	a	DT
cord-006229-7yoilsho	1343	8	higher	high	JJR
cord-006229-7yoilsho	1343	9	potency	potency	NN
cord-006229-7yoilsho	1343	10	of	of	IN
cord-006229-7yoilsho	1343	11	8-OH	8-oh	CD
cord-006229-7yoilsho	1343	12	-	-	HYPH
cord-006229-7yoilsho	1343	13	DPAT	dpat	NN
cord-006229-7yoilsho	1343	14	in	in	IN
cord-006229-7yoilsho	1343	15	transgenic	transgenic	JJ
cord-006229-7yoilsho	1343	16	mice	mouse	NNS
cord-006229-7yoilsho	1343	17	.	.	.
cord-006229-7yoilsho	1344	1	The	the	DT
cord-006229-7yoilsho	1344	2	exaggerated	exaggerated	JJ
cord-006229-7yoilsho	1344	3	hypothermic	hypothermic	JJ
cord-006229-7yoilsho	1344	4	response	response	NN
cord-006229-7yoilsho	1344	5	to	to	IN
cord-006229-7yoilsho	1344	6	8-OH	8-oh	CD
cord-006229-7yoilsho	1344	7	-	-	HYPH
cord-006229-7yoilsho	1344	8	DPAT	dpat	NN
cord-006229-7yoilsho	1344	9	in	in	IN
cord-006229-7yoilsho	1344	10	mutant	mutant	JJ
cord-006229-7yoilsho	1344	11	mice	mouse	NNS
cord-006229-7yoilsho	1344	12	implies	imply	VBZ
cord-006229-7yoilsho	1344	13	that	that	IN
cord-006229-7yoilsho	1344	14	postsynaptic	postsynaptic	JJ
cord-006229-7yoilsho	1344	15	5-HT	5-ht	CD
cord-006229-7yoilsho	1344	16	1A	1a	NN
cord-006229-7yoilsho	1344	17	receptors	receptor	NNS
cord-006229-7yoilsho	1344	18	could	could	MD
cord-006229-7yoilsho	1344	19	be	be	VB
cord-006229-7yoilsho	1344	20	involved	involve	VBN
cord-006229-7yoilsho	1344	21	in	in	IN
cord-006229-7yoilsho	1344	22	thermoregulatory	thermoregulatory	JJ
cord-006229-7yoilsho	1344	23	function	function	NN
cord-006229-7yoilsho	1344	24	in	in	IN
cord-006229-7yoilsho	1344	25	mice	mouse	NNS
cord-006229-7yoilsho	1344	26	.	.	.
cord-006229-7yoilsho	1345	1	This	this	DT
cord-006229-7yoilsho	1345	2	assumption	assumption	NN
cord-006229-7yoilsho	1345	3	is	be	VBZ
cord-006229-7yoilsho	1345	4	further	far	RBR
cord-006229-7yoilsho	1345	5	confirmed	confirm	VBN
cord-006229-7yoilsho	1345	6	by	by	IN
cord-006229-7yoilsho	1345	7	the	the	DT
cord-006229-7yoilsho	1345	8	fact	fact	NN
cord-006229-7yoilsho	1345	9	that	that	IN
cord-006229-7yoilsho	1345	10	8-OH	8-oh	CD
cord-006229-7yoilsho	1345	11	-	-	HYPH
cord-006229-7yoilsho	1345	12	DPATevoked	dpatevoke	VBN
cord-006229-7yoilsho	1345	13	thermal	thermal	JJ
cord-006229-7yoilsho	1345	14	responses	response	NNS
cord-006229-7yoilsho	1345	15	were	be	VBD
cord-006229-7yoilsho	1345	16	not	not	RB
cord-006229-7yoilsho	1345	17	influenced	influence	VBN
cord-006229-7yoilsho	1345	18	by	by	IN
cord-006229-7yoilsho	1345	19	pretreatment	pretreatment	NN
cord-006229-7yoilsho	1345	20	with	with	IN
cord-006229-7yoilsho	1345	21	PCPA	PCPA	NNP
cord-006229-7yoilsho	1345	22	,	,	,
cord-006229-7yoilsho	1345	23	most	most	RBS
cord-006229-7yoilsho	1345	24	notably	notably	RB
cord-006229-7yoilsho	1345	25	in	in	IN
cord-006229-7yoilsho	1345	26	transgenic	transgenic	JJ
cord-006229-7yoilsho	1345	27	mice	mouse	NNS
cord-006229-7yoilsho	1345	28	overexpressing	overexpresse	VBG
cord-006229-7yoilsho	1345	29	5-HT	5-ht	CD
cord-006229-7yoilsho	1345	30	1A	1A	NNP
cord-006229-7yoilsho	1345	31	receptors	receptor	NNS
cord-006229-7yoilsho	1345	32	postsynaptically	postsynaptically	VBP
cord-006229-7yoilsho	1345	33	.	.	.
cord-006229-7yoilsho	1346	1	Genetic	genetic	JJ
cord-006229-7yoilsho	1346	2	variation	variation	NN
cord-006229-7yoilsho	1346	3	within	within	IN
cord-006229-7yoilsho	1346	4	G	g	NN
cord-006229-7yoilsho	1346	5	protein	protein	NN
cord-006229-7yoilsho	1346	6	-	-	HYPH
cord-006229-7yoilsho	1346	7	coupled	couple	VBN
cord-006229-7yoilsho	1346	8	receptors	receptor	NNS
cord-006229-7yoilsho	1346	9	compromises	compromise	VBZ
cord-006229-7yoilsho	1346	10	the	the	DT
cord-006229-7yoilsho	1346	11	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	1346	12	application	application	NN
cord-006229-7yoilsho	1346	13	of	of	IN
cord-006229-7yoilsho	1346	14	drugs	drug	NNS
cord-006229-7yoilsho	1346	15	targeting	target	VBG
cord-006229-7yoilsho	1346	16	these	these	DT
cord-006229-7yoilsho	1346	17	receptors	receptor	NNS
cord-006229-7yoilsho	1346	18	.	.	.
cord-006229-7yoilsho	1347	1	One	one	CD
cord-006229-7yoilsho	1347	2	of	of	IN
cord-006229-7yoilsho	1347	3	the	the	DT
cord-006229-7yoilsho	1347	4	most	most	RBS
cord-006229-7yoilsho	1347	5	intensely	intensely	RB
cord-006229-7yoilsho	1347	6	studied	study	VBN
cord-006229-7yoilsho	1347	7	variation	variation	NN
cord-006229-7yoilsho	1347	8	is	be	VBZ
cord-006229-7yoilsho	1347	9	p.	p.	NN
cord-006229-7yoilsho	1348	1	Arg389Gly	arg389gly	XX
cord-006229-7yoilsho	1348	2	in	in	IN
cord-006229-7yoilsho	1348	3	the	the	DT
cord-006229-7yoilsho	1348	4	human	human	JJ
cord-006229-7yoilsho	1348	5	beta1-adrenoceptor	beta1-adrenoceptor	NN
cord-006229-7yoilsho	1348	6	(	(	-LRB-
cord-006229-7yoilsho	1348	7	ADRB1	ADRB1	NNP
cord-006229-7yoilsho	1348	8	)	)	-RRB-
cord-006229-7yoilsho	1348	9	.	.	.
cord-006229-7yoilsho	1349	1	The	the	DT
cord-006229-7yoilsho	1349	2	ADRB1	ADRB1	``
cord-006229-7yoilsho	1349	3	carrying	carry	VBG
cord-006229-7yoilsho	1349	4	arginine	arginine	NN
cord-006229-7yoilsho	1349	5	at	at	IN
cord-006229-7yoilsho	1349	6	position	position	NN
cord-006229-7yoilsho	1349	7	389	389	CD
cord-006229-7yoilsho	1349	8	in	in	IN
cord-006229-7yoilsho	1349	9	helix	helix	NN
cord-006229-7yoilsho	1349	10	8	8	CD
cord-006229-7yoilsho	1349	11	in	in	IN
cord-006229-7yoilsho	1349	12	the	the	DT
cord-006229-7yoilsho	1349	13	proximal	proximal	JJ
cord-006229-7yoilsho	1349	14	carboxy	carboxy	JJ
cord-006229-7yoilsho	1349	15	terminus	terminus	NN
cord-006229-7yoilsho	1349	16	is	be	VBZ
cord-006229-7yoilsho	1349	17	more	more	RBR
cord-006229-7yoilsho	1349	18	frequent	frequent	JJ
cord-006229-7yoilsho	1349	19	among	among	IN
cord-006229-7yoilsho	1349	20	Caucasians	Caucasians	NNPS
cord-006229-7yoilsho	1349	21	and	and	CC
cord-006229-7yoilsho	1349	22	is	be	VBZ
cord-006229-7yoilsho	1349	23	hyperfunctional	hyperfunctional	NNP
cord-006229-7yoilsho	1349	24	.	.	.
cord-006229-7yoilsho	1350	1	Yet	yet	RB
cord-006229-7yoilsho	1350	2	,	,	,
cord-006229-7yoilsho	1350	3	the	the	DT
cord-006229-7yoilsho	1350	4	molecular	molecular	JJ
cord-006229-7yoilsho	1350	5	basis	basis	NN
cord-006229-7yoilsho	1350	6	for	for	IN
cord-006229-7yoilsho	1350	7	the	the	DT
cord-006229-7yoilsho	1350	8	differences	difference	NNS
cord-006229-7yoilsho	1350	9	between	between	IN
cord-006229-7yoilsho	1350	10	the	the	DT
cord-006229-7yoilsho	1350	11	beta1-adrenoceptor	beta1-adrenoceptor	NN
cord-006229-7yoilsho	1350	12	variants	variant	NNS
cord-006229-7yoilsho	1350	13	Arg389-ADRB1	arg389-adrb1	JJ
cord-006229-7yoilsho	1350	14	and	and	CC
cord-006229-7yoilsho	1350	15	Gly389-ADRB1	gly389-adrb1	NN
cord-006229-7yoilsho	1350	16	is	be	VBZ
cord-006229-7yoilsho	1350	17	poorly	poorly	RB
cord-006229-7yoilsho	1350	18	understood	understand	VBN
cord-006229-7yoilsho	1350	19	.	.	.
cord-006229-7yoilsho	1351	1	Despite	despite	IN
cord-006229-7yoilsho	1351	2	its	-PRON-	PRP$
cord-006229-7yoilsho	1351	3	hyperfunctionality	hyperfunctionality	NN
cord-006229-7yoilsho	1351	4	,	,	,
cord-006229-7yoilsho	1351	5	we	-PRON-	PRP
cord-006229-7yoilsho	1351	6	found	find	VBD
cord-006229-7yoilsho	1351	7	the	the	DT
cord-006229-7yoilsho	1351	8	Arg389-variant	arg389-variant	NN
cord-006229-7yoilsho	1351	9	of	of	IN
cord-006229-7yoilsho	1351	10	the	the	DT
cord-006229-7yoilsho	1351	11	ADRB1	ADRB1	NNP
cord-006229-7yoilsho	1351	12	to	to	TO
cord-006229-7yoilsho	1351	13	be	be	VB
cord-006229-7yoilsho	1351	14	hyperphosphorylated	hyperphosphorylate	VBN
cord-006229-7yoilsho	1351	15	upon	upon	IN
cord-006229-7yoilsho	1351	16	continuous	continuous	JJ
cord-006229-7yoilsho	1351	17	stimulation	stimulation	NN
cord-006229-7yoilsho	1351	18	with	with	IN
cord-006229-7yoilsho	1351	19	norepinephrine	norepinephrine	NN
cord-006229-7yoilsho	1351	20	when	when	WRB
cord-006229-7yoilsho	1351	21	compared	compare	VBN
cord-006229-7yoilsho	1351	22	to	to	IN
cord-006229-7yoilsho	1351	23	the	the	DT
cord-006229-7yoilsho	1351	24	Gly389-variant	gly389-variant	NN
cord-006229-7yoilsho	1351	25	.	.	.
cord-006229-7yoilsho	1352	1	Using	use	VBG
cord-006229-7yoilsho	1352	2	ADRB1	adrb1	PRP$
cord-006229-7yoilsho	1352	3	sensors	sensor	NNS
cord-006229-7yoilsho	1352	4	to	to	TO
cord-006229-7yoilsho	1352	5	monitor	monitor	VB
cord-006229-7yoilsho	1352	6	activation	activation	NN
cord-006229-7yoilsho	1352	7	kinetics	kinetic	NNS
cord-006229-7yoilsho	1352	8	by	by	IN
cord-006229-7yoilsho	1352	9	fluorescence	fluorescence	NN
cord-006229-7yoilsho	1352	10	resonance	resonance	NN
cord-006229-7yoilsho	1352	11	energy	energy	NN
cord-006229-7yoilsho	1352	12	transfer	transfer	NN
cord-006229-7yoilsho	1352	13	(	(	-LRB-
cord-006229-7yoilsho	1352	14	FRET	FRET	NNP
cord-006229-7yoilsho	1352	15	)	)	-RRB-
cord-006229-7yoilsho	1352	16	,	,	,
cord-006229-7yoilsho	1352	17	the	the	DT
cord-006229-7yoilsho	1352	18	Arg389-ADRB1	Arg389-ADRB1	NNP
cord-006229-7yoilsho	1352	19	exerted	exert	VBD
cord-006229-7yoilsho	1352	20	faster	fast	JJR
cord-006229-7yoilsho	1352	21	activation	activation	NN
cord-006229-7yoilsho	1352	22	speed	speed	NN
cord-006229-7yoilsho	1352	23	and	and	CC
cord-006229-7yoilsho	1352	24	arrestin	arrestin	NN
cord-006229-7yoilsho	1352	25	recruitment	recruitment	NN
cord-006229-7yoilsho	1352	26	than	than	IN
cord-006229-7yoilsho	1352	27	the	the	DT
cord-006229-7yoilsho	1352	28	Gly389-variant	gly389-variant	NN
cord-006229-7yoilsho	1352	29	.	.	.
cord-006229-7yoilsho	1353	1	Both	both	DT
cord-006229-7yoilsho	1353	2	depended	depend	VBD
cord-006229-7yoilsho	1353	3	on	on	IN
cord-006229-7yoilsho	1353	4	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	1353	5	of	of	IN
cord-006229-7yoilsho	1353	6	the	the	DT
cord-006229-7yoilsho	1353	7	receptor	receptor	NN
cord-006229-7yoilsho	1353	8	as	as	IN
cord-006229-7yoilsho	1353	9	shown	show	VBN
cord-006229-7yoilsho	1353	10	by	by	IN
cord-006229-7yoilsho	1353	11	knockdown	knockdown	NN
cord-006229-7yoilsho	1353	12	of	of	IN
cord-006229-7yoilsho	1353	13	G	g	NN
cord-006229-7yoilsho	1353	14	protein	protein	NN
cord-006229-7yoilsho	1353	15	-	-	HYPH
cord-006229-7yoilsho	1353	16	coupled	couple	VBN
cord-006229-7yoilsho	1353	17	receptor	receptor	NN
cord-006229-7yoilsho	1353	18	kinases	kinase	NNS
cord-006229-7yoilsho	1353	19	and	and	CC
cord-006229-7yoilsho	1353	20	by	by	IN
cord-006229-7yoilsho	1353	21	FRET	fret	NN
cord-006229-7yoilsho	1353	22	experiments	experiment	NNS
cord-006229-7yoilsho	1353	23	using	use	VBG
cord-006229-7yoilsho	1353	24	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	1353	25	-	-	HYPH
cord-006229-7yoilsho	1353	26	deficient	deficient	JJ
cord-006229-7yoilsho	1353	27	ADRB1	adrb1	PRP$
cord-006229-7yoilsho	1353	28	mutants	mutant	NNS
cord-006229-7yoilsho	1353	29	.	.	.
cord-006229-7yoilsho	1354	1	Point	point	NN
cord-006229-7yoilsho	1354	2	mutation	mutation	NN
cord-006229-7yoilsho	1354	3	of	of	IN
cord-006229-7yoilsho	1354	4	single	single	JJ
cord-006229-7yoilsho	1354	5	serines	serines	NNPS
cord-006229-7yoilsho	1354	6	and	and	CC
cord-006229-7yoilsho	1354	7	threonines	threonine	NNS
cord-006229-7yoilsho	1354	8	in	in	IN
cord-006229-7yoilsho	1354	9	the	the	DT
cord-006229-7yoilsho	1354	10	carboxy	carboxy	JJ
cord-006229-7yoilsho	1354	11	terminus	terminus	NN
cord-006229-7yoilsho	1354	12	of	of	IN
cord-006229-7yoilsho	1354	13	the	the	DT
cord-006229-7yoilsho	1354	14	ADRB1	ADRB1	NNP
cord-006229-7yoilsho	1354	15	finally	finally	RB
cord-006229-7yoilsho	1354	16	revealed	reveal	VBD
cord-006229-7yoilsho	1354	17	a	a	DT
cord-006229-7yoilsho	1354	18	variant	variant	NN
cord-006229-7yoilsho	1354	19	-	-	HYPH
cord-006229-7yoilsho	1354	20	specific	specific	JJ
cord-006229-7yoilsho	1354	21	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	1354	22	pattern	pattern	NN
cord-006229-7yoilsho	1354	23	that	that	WDT
cord-006229-7yoilsho	1354	24	determines	determine	VBZ
cord-006229-7yoilsho	1354	25	arrestin	arrestin	NNP
cord-006229-7yoilsho	1354	26	recruitment	recruitment	NN
cord-006229-7yoilsho	1354	27	.	.	.
cord-006229-7yoilsho	1355	1	Taken	take	VBN
cord-006229-7yoilsho	1355	2	together	together	RB
cord-006229-7yoilsho	1355	3	,	,	,
cord-006229-7yoilsho	1355	4	these	these	DT
cord-006229-7yoilsho	1355	5	findings	finding	NNS
cord-006229-7yoilsho	1355	6	suggest	suggest	VBP
cord-006229-7yoilsho	1355	7	that	that	IN
cord-006229-7yoilsho	1355	8	differences	difference	NNS
cord-006229-7yoilsho	1355	9	in	in	IN
cord-006229-7yoilsho	1355	10	receptor	receptor	NN
cord-006229-7yoilsho	1355	11	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	1355	12	determine	determine	VBP
cord-006229-7yoilsho	1355	13	the	the	DT
cord-006229-7yoilsho	1355	14	differences	difference	NNS
cord-006229-7yoilsho	1355	15	in	in	IN
cord-006229-7yoilsho	1355	16	activation	activation	NN
cord-006229-7yoilsho	1355	17	speed	speed	NN
cord-006229-7yoilsho	1355	18	,	,	,
cord-006229-7yoilsho	1355	19	efficacy	efficacy	NN
cord-006229-7yoilsho	1355	20	and	and	CC
cord-006229-7yoilsho	1355	21	arrestin	arrestin	NNP
cord-006229-7yoilsho	1355	22	recruitment	recruitment	NN
cord-006229-7yoilsho	1355	23	of	of	IN
cord-006229-7yoilsho	1355	24	ADRB1	ADRB1	NNP
cord-006229-7yoilsho	1355	25	variants	variant	NNS
cord-006229-7yoilsho	1355	26	.	.	.
cord-006229-7yoilsho	1356	1	Opioid	opioid	JJ
cord-006229-7yoilsho	1356	2	drugs	drug	NNS
cord-006229-7yoilsho	1356	3	are	be	VBP
cord-006229-7yoilsho	1356	4	the	the	DT
cord-006229-7yoilsho	1356	5	most	most	RBS
cord-006229-7yoilsho	1356	6	potent	potent	JJ
cord-006229-7yoilsho	1356	7	analgesics	analgesic	NNS
cord-006229-7yoilsho	1356	8	,	,	,
cord-006229-7yoilsho	1356	9	which	which	WDT
cord-006229-7yoilsho	1356	10	are	be	VBP
cord-006229-7yoilsho	1356	11	used	use	VBN
cord-006229-7yoilsho	1356	12	in	in	IN
cord-006229-7yoilsho	1356	13	the	the	DT
cord-006229-7yoilsho	1356	14	clinic	clinic	NN
cord-006229-7yoilsho	1356	15	;	;	:
cord-006229-7yoilsho	1356	16	however	however	RB
cord-006229-7yoilsho	1356	17	,	,	,
cord-006229-7yoilsho	1356	18	by	by	IN
cord-006229-7yoilsho	1356	19	activating	activate	VBG
cord-006229-7yoilsho	1356	20	the	the	DT
cord-006229-7yoilsho	1356	21	μ	μ	NN
cord-006229-7yoilsho	1356	22	-	-	HYPH
cord-006229-7yoilsho	1356	23	opioid	opioid	NN
cord-006229-7yoilsho	1356	24	receptor	receptor	NN
cord-006229-7yoilsho	1356	25	(	(	-LRB-
cord-006229-7yoilsho	1356	26	MOR	MOR	NNP
cord-006229-7yoilsho	1356	27	)	)	-RRB-
cord-006229-7yoilsho	1356	28	they	-PRON-	PRP
cord-006229-7yoilsho	1356	29	also	also	RB
cord-006229-7yoilsho	1356	30	produce	produce	VBP
cord-006229-7yoilsho	1356	31	several	several	JJ
cord-006229-7yoilsho	1356	32	adverse	adverse	JJ
cord-006229-7yoilsho	1356	33	side	side	NN
cord-006229-7yoilsho	1356	34	effects	effect	NNS
cord-006229-7yoilsho	1356	35	including	include	VBG
cord-006229-7yoilsho	1356	36	constipation	constipation	NN
cord-006229-7yoilsho	1356	37	,	,	,
cord-006229-7yoilsho	1356	38	antinociceptive	antinociceptive	JJ
cord-006229-7yoilsho	1356	39	tolerance	tolerance	NN
cord-006229-7yoilsho	1356	40	,	,	,
cord-006229-7yoilsho	1356	41	and	and	CC
cord-006229-7yoilsho	1356	42	physical	physical	JJ
cord-006229-7yoilsho	1356	43	dependence	dependence	NN
cord-006229-7yoilsho	1356	44	.	.	.
cord-006229-7yoilsho	1357	1	There	there	EX
cord-006229-7yoilsho	1357	2	is	be	VBZ
cord-006229-7yoilsho	1357	3	substantial	substantial	JJ
cord-006229-7yoilsho	1357	4	evidence	evidence	NN
cord-006229-7yoilsho	1357	5	suggesting	suggest	VBG
cord-006229-7yoilsho	1357	6	that	that	IN
cord-006229-7yoilsho	1357	7	G	g	NN
cord-006229-7yoilsho	1357	8	protein	protein	NN
cord-006229-7yoilsho	1357	9	-	-	HYPH
cord-006229-7yoilsho	1357	10	coupled	couple	VBN
cord-006229-7yoilsho	1357	11	receptor	receptor	NN
cord-006229-7yoilsho	1357	12	kinases	kinase	NNS
cord-006229-7yoilsho	1357	13	(	(	-LRB-
cord-006229-7yoilsho	1357	14	GRKs	GRKs	NNP
cord-006229-7yoilsho	1357	15	)	)	-RRB-
cord-006229-7yoilsho	1357	16	and	and	CC
cord-006229-7yoilsho	1357	17	βarrestins	βarrestin	NNS
cord-006229-7yoilsho	1357	18	play	play	VBP
cord-006229-7yoilsho	1357	19	key	key	JJ
cord-006229-7yoilsho	1357	20	roles	role	NNS
cord-006229-7yoilsho	1357	21	in	in	IN
cord-006229-7yoilsho	1357	22	regulating	regulate	VBG
cord-006229-7yoilsho	1357	23	MOR	MOR	NNP
cord-006229-7yoilsho	1357	24	signaling	signaling	NN
cord-006229-7yoilsho	1357	25	and	and	CC
cord-006229-7yoilsho	1357	26	responsiveness	responsiveness	NN
cord-006229-7yoilsho	1357	27	.	.	.
cord-006229-7yoilsho	1358	1	Following	follow	VBG
cord-006229-7yoilsho	1358	2	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	1358	3	by	by	IN
cord-006229-7yoilsho	1358	4	GRKs	grk	NNS
cord-006229-7yoilsho	1358	5	,	,	,
cord-006229-7yoilsho	1358	6	β	β	NN
cord-006229-7yoilsho	1358	7	-	-	HYPH
cord-006229-7yoilsho	1358	8	arrestins	arrestin	NNS
cord-006229-7yoilsho	1358	9	bind	bind	VBP
cord-006229-7yoilsho	1358	10	to	to	IN
cord-006229-7yoilsho	1358	11	phosphorylated	phosphorylated	JJ
cord-006229-7yoilsho	1358	12	MORs	mor	NNS
cord-006229-7yoilsho	1358	13	,	,	,
cord-006229-7yoilsho	1358	14	which	which	WDT
cord-006229-7yoilsho	1358	15	prevents	prevent	VBZ
cord-006229-7yoilsho	1358	16	further	further	JJ
cord-006229-7yoilsho	1358	17	interactions	interaction	NNS
cord-006229-7yoilsho	1358	18	between	between	IN
cord-006229-7yoilsho	1358	19	the	the	DT
cord-006229-7yoilsho	1358	20	receptor	receptor	NN
cord-006229-7yoilsho	1358	21	and	and	CC
cord-006229-7yoilsho	1358	22	G	g	NN
cord-006229-7yoilsho	1358	23	proteins	protein	NNS
cord-006229-7yoilsho	1358	24	even	even	RB
cord-006229-7yoilsho	1358	25	in	in	IN
cord-006229-7yoilsho	1358	26	the	the	DT
cord-006229-7yoilsho	1358	27	continued	continued	JJ
cord-006229-7yoilsho	1358	28	presence	presence	NN
cord-006229-7yoilsho	1358	29	of	of	IN
cord-006229-7yoilsho	1358	30	agonist	agonist	NN
cord-006229-7yoilsho	1358	31	resulting	result	VBG
cord-006229-7yoilsho	1358	32	in	in	IN
cord-006229-7yoilsho	1358	33	diminished	diminished	JJ
cord-006229-7yoilsho	1358	34	G	g	NN
cord-006229-7yoilsho	1358	35	protein	protein	NN
cord-006229-7yoilsho	1358	36	-	-	HYPH
cord-006229-7yoilsho	1358	37	mediated	mediate	VBN
cord-006229-7yoilsho	1358	38	signaling	signaling	NN
cord-006229-7yoilsho	1358	39	.	.	.
cord-006229-7yoilsho	1359	1	We	-PRON-	PRP
cord-006229-7yoilsho	1359	2	have	have	VBP
cord-006229-7yoilsho	1359	3	previously	previously	RB
cord-006229-7yoilsho	1359	4	shown	show	VBN
cord-006229-7yoilsho	1359	5	that	that	IN
cord-006229-7yoilsho	1359	6	agonist	agonist	NN
cord-006229-7yoilsho	1359	7	-	-	HYPH
cord-006229-7yoilsho	1359	8	induced	induce	VBN
cord-006229-7yoilsho	1359	9	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	1359	10	of	of	IN
cord-006229-7yoilsho	1359	11	MOR	MOR	NNP
cord-006229-7yoilsho	1359	12	occurs	occur	VBZ
cord-006229-7yoilsho	1359	13	at	at	IN
cord-006229-7yoilsho	1359	14	a	a	DT
cord-006229-7yoilsho	1359	15	conserved	conserved	JJ
cord-006229-7yoilsho	1359	16	10-residue	10-residue	CD
cord-006229-7yoilsho	1359	17	sequence	sequence	NN
cord-006229-7yoilsho	1359	18	,	,	,
cord-006229-7yoilsho	1359	19	370	370	CD
cord-006229-7yoilsho	1359	20	TREHPSTANT	TREHPSTANT	NNP
cord-006229-7yoilsho	1359	21	379	379	CD
cord-006229-7yoilsho	1359	22	,	,	,
cord-006229-7yoilsho	1359	23	in	in	IN
cord-006229-7yoilsho	1359	24	the	the	DT
cord-006229-7yoilsho	1359	25	carboxyl	carboxyl	NN
cord-006229-7yoilsho	1359	26	-	-	HYPH
cord-006229-7yoilsho	1359	27	terminal	terminal	NN
cord-006229-7yoilsho	1359	28	cytoplasmic	cytoplasmic	JJ
cord-006229-7yoilsho	1359	29	tail	tail	NN
cord-006229-7yoilsho	1359	30	.	.	.
cord-006229-7yoilsho	1360	1	Morphine	morphine	NN
cord-006229-7yoilsho	1360	2	induces	induce	VBZ
cord-006229-7yoilsho	1360	3	a	a	DT
cord-006229-7yoilsho	1360	4	selective	selective	JJ
cord-006229-7yoilsho	1360	5	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	1360	6	of	of	IN
cord-006229-7yoilsho	1360	7	serine	serine	NN
cord-006229-7yoilsho	1360	8	375	375	CD
cord-006229-7yoilsho	1360	9	(	(	-LRB-
cord-006229-7yoilsho	1360	10	S375	S375	NFP
cord-006229-7yoilsho	1360	11	)	)	-RRB-
cord-006229-7yoilsho	1360	12	in	in	IN
cord-006229-7yoilsho	1360	13	the	the	DT
cord-006229-7yoilsho	1360	14	middle	middle	NN
cord-006229-7yoilsho	1360	15	of	of	IN
cord-006229-7yoilsho	1360	16	this	this	DT
cord-006229-7yoilsho	1360	17	sequence	sequence	NN
cord-006229-7yoilsho	1360	18	that	that	WDT
cord-006229-7yoilsho	1360	19	is	be	VBZ
cord-006229-7yoilsho	1360	20	predominantly	predominantly	RB
cord-006229-7yoilsho	1360	21	catalyzed	catalyze	VBN
cord-006229-7yoilsho	1360	22	by	by	IN
cord-006229-7yoilsho	1360	23	G	g	NN
cord-006229-7yoilsho	1360	24	protein	protein	NN
cord-006229-7yoilsho	1360	25	-	-	HYPH
cord-006229-7yoilsho	1360	26	coupled	couple	VBN
cord-006229-7yoilsho	1360	27	receptor	receptor	NN
cord-006229-7yoilsho	1360	28	kinase	kinase	NN
cord-006229-7yoilsho	1360	29	5	5	CD
cord-006229-7yoilsho	1360	30	(	(	-LRB-
cord-006229-7yoilsho	1360	31	GRK5	GRK5	NNP
cord-006229-7yoilsho	1360	32	)	)	-RRB-
cord-006229-7yoilsho	1360	33	.	.	.
cord-006229-7yoilsho	1361	1	By	by	IN
cord-006229-7yoilsho	1361	2	contrast	contrast	NN
cord-006229-7yoilsho	1361	3	,	,	,
cord-006229-7yoilsho	1361	4	high	high	JJ
cord-006229-7yoilsho	1361	5	-	-	HYPH
cord-006229-7yoilsho	1361	6	efficacy	efficacy	NN
cord-006229-7yoilsho	1361	7	opioids	opioid	NNS
cord-006229-7yoilsho	1361	8	not	not	RB
cord-006229-7yoilsho	1361	9	only	only	RB
cord-006229-7yoilsho	1361	10	induce	induce	VBP
cord-006229-7yoilsho	1361	11	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	1361	12	of	of	IN
cord-006229-7yoilsho	1361	13	S375	s375	NN
cord-006229-7yoilsho	1361	14	but	but	CC
cord-006229-7yoilsho	1361	15	also	also	RB
cord-006229-7yoilsho	1361	16	drive	drive	VBP
cord-006229-7yoilsho	1361	17	higher	high	JJR
cord-006229-7yoilsho	1361	18	-	-	HYPH
cord-006229-7yoilsho	1361	19	order	order	NN
cord-006229-7yoilsho	1361	20	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	1361	21	on	on	IN
cord-006229-7yoilsho	1361	22	the	the	DT
cord-006229-7yoilsho	1361	23	flanking	flank	VBG
cord-006229-7yoilsho	1361	24	residues	residue	NNS
cord-006229-7yoilsho	1361	25	threonine	threonine	NNP
cord-006229-7yoilsho	1361	26	370	370	CD
cord-006229-7yoilsho	1361	27	(	(	-LRB-
cord-006229-7yoilsho	1361	28	T370	t370	CD
cord-006229-7yoilsho	1361	29	)	)	-RRB-
cord-006229-7yoilsho	1361	30	,	,	.
cord-006229-7yoilsho	1362	1	threonine	threonine	NNP
cord-006229-7yoilsho	1362	2	376	376	CD
cord-006229-7yoilsho	1362	3	(	(	-LRB-
cord-006229-7yoilsho	1362	4	T376	T376	NNP
cord-006229-7yoilsho	1362	5	)	)	-RRB-
cord-006229-7yoilsho	1362	6	,	,	,
cord-006229-7yoilsho	1362	7	and	and	CC
cord-006229-7yoilsho	1362	8	threonine	threonine	NN
cord-006229-7yoilsho	1362	9	379	379	CD
cord-006229-7yoilsho	1362	10	(	(	-LRB-
cord-006229-7yoilsho	1362	11	T379	T379	NNP
cord-006229-7yoilsho	1362	12	)	)	-RRB-
cord-006229-7yoilsho	1362	13	in	in	IN
cord-006229-7yoilsho	1362	14	a	a	DT
cord-006229-7yoilsho	1362	15	hierarchical	hierarchical	JJ
cord-006229-7yoilsho	1362	16	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	1362	17	cascade	cascade	NN
cord-006229-7yoilsho	1362	18	that	that	WDT
cord-006229-7yoilsho	1362	19	specifically	specifically	RB
cord-006229-7yoilsho	1362	20	requires	require	VBZ
cord-006229-7yoilsho	1362	21	GRK2/3	GRK2/3	NNP
cord-006229-7yoilsho	1362	22	isoforms	isoform	NNS
cord-006229-7yoilsho	1362	23	.	.	.
cord-006229-7yoilsho	1363	1	To	to	TO
cord-006229-7yoilsho	1363	2	investigate	investigate	VB
cord-006229-7yoilsho	1363	3	this	this	DT
cord-006229-7yoilsho	1363	4	mechanism	mechanism	NN
cord-006229-7yoilsho	1363	5	further	far	RBR
cord-006229-7yoilsho	1363	6	,	,	,
cord-006229-7yoilsho	1363	7	we	-PRON-	PRP
cord-006229-7yoilsho	1363	8	have	have	VBP
cord-006229-7yoilsho	1363	9	developed	develop	VBN
cord-006229-7yoilsho	1363	10	novel	novel	NN
cord-006229-7yoilsho	1363	11	β	β	NN
cord-006229-7yoilsho	1363	12	-	-	HYPH
cord-006229-7yoilsho	1363	13	galactosidase	galactosidase	NN
cord-006229-7yoilsho	1363	14	complementation	complementation	NN
cord-006229-7yoilsho	1363	15	assays	assay	NNS
cord-006229-7yoilsho	1363	16	to	to	TO
cord-006229-7yoilsho	1363	17	monitor	monitor	VB
cord-006229-7yoilsho	1363	18	agonist	agonist	NN
cord-006229-7yoilsho	1363	19	-	-	HYPH
cord-006229-7yoilsho	1363	20	dependent	dependent	JJ
cord-006229-7yoilsho	1363	21	recruitment	recruitment	NN
cord-006229-7yoilsho	1363	22	of	of	IN
cord-006229-7yoilsho	1363	23	GRK2	GRK2	NNP
cord-006229-7yoilsho	1363	24	and	and	CC
cord-006229-7yoilsho	1363	25	GRK3	GRK3	NNP
cord-006229-7yoilsho	1363	26	to	to	IN
cord-006229-7yoilsho	1363	27	activated	activate	VBN
cord-006229-7yoilsho	1363	28	MORs	mor	NNS
cord-006229-7yoilsho	1363	29	.	.	.
cord-006229-7yoilsho	1364	1	Using	use	VBG
cord-006229-7yoilsho	1364	2	this	this	DT
cord-006229-7yoilsho	1364	3	assay	assay	NN
cord-006229-7yoilsho	1364	4	,	,	,
cord-006229-7yoilsho	1364	5	we	-PRON-	PRP
cord-006229-7yoilsho	1364	6	were	be	VBD
cord-006229-7yoilsho	1364	7	able	able	JJ
cord-006229-7yoilsho	1364	8	to	to	TO
cord-006229-7yoilsho	1364	9	show	show	VB
cord-006229-7yoilsho	1364	10	that	that	DT
cord-006229-7yoilsho	1364	11	activation	activation	NN
cord-006229-7yoilsho	1364	12	of	of	IN
cord-006229-7yoilsho	1364	13	MOR	MOR	NNP
cord-006229-7yoilsho	1364	14	by	by	IN
cord-006229-7yoilsho	1364	15	high	high	JJ
cord-006229-7yoilsho	1364	16	-	-	HYPH
cord-006229-7yoilsho	1364	17	efficacy	efficacy	NN
cord-006229-7yoilsho	1364	18	agonists	agonist	NNS
cord-006229-7yoilsho	1364	19	such	such	JJ
cord-006229-7yoilsho	1364	20	as	as	IN
cord-006229-7yoilsho	1364	21	DAMGO	DAMGO	NNP
cord-006229-7yoilsho	1364	22	results	result	VBZ
cord-006229-7yoilsho	1364	23	in	in	IN
cord-006229-7yoilsho	1364	24	a	a	DT
cord-006229-7yoilsho	1364	25	robust	robust	JJ
cord-006229-7yoilsho	1364	26	translocation	translocation	NN
cord-006229-7yoilsho	1364	27	of	of	IN
cord-006229-7yoilsho	1364	28	GRK2/3	GRK2/3	NNP
cord-006229-7yoilsho	1364	29	.	.	.
cord-006229-7yoilsho	1365	1	In	in	IN
cord-006229-7yoilsho	1365	2	contrast	contrast	NN
cord-006229-7yoilsho	1365	3	,	,	,
cord-006229-7yoilsho	1365	4	activation	activation	NN
cord-006229-7yoilsho	1365	5	by	by	IN
cord-006229-7yoilsho	1365	6	low	low	JJ
cord-006229-7yoilsho	1365	7	-	-	HYPH
cord-006229-7yoilsho	1365	8	efficacy	efficacy	NN
cord-006229-7yoilsho	1365	9	agonists	agonist	NNS
cord-006229-7yoilsho	1365	10	such	such	JJ
cord-006229-7yoilsho	1365	11	as	as	IN
cord-006229-7yoilsho	1365	12	morphine	morphine	NN
cord-006229-7yoilsho	1365	13	results	result	NNS
cord-006229-7yoilsho	1365	14	in	in	IN
cord-006229-7yoilsho	1365	15	a	a	DT
cord-006229-7yoilsho	1365	16	much	much	RB
cord-006229-7yoilsho	1365	17	less	less	RBR
cord-006229-7yoilsho	1365	18	pronounced	pronounced	JJ
cord-006229-7yoilsho	1365	19	recruitment	recruitment	NN
cord-006229-7yoilsho	1365	20	of	of	IN
cord-006229-7yoilsho	1365	21	GRK2/3	GRK2/3	NNP
cord-006229-7yoilsho	1365	22	isoforms	isoform	NNS
cord-006229-7yoilsho	1365	23	.	.	.
cord-006229-7yoilsho	1366	1	Interestingly	interestingly	RB
cord-006229-7yoilsho	1366	2	,	,	,
cord-006229-7yoilsho	1366	3	DAMGO	DAMGO	NNP
cord-006229-7yoilsho	1366	4	-	-	HYPH
cord-006229-7yoilsho	1366	5	induced	induce	VBN
cord-006229-7yoilsho	1366	6	β	β	NN
cord-006229-7yoilsho	1366	7	-	-	HYPH
cord-006229-7yoilsho	1366	8	arrestin	arrestin	NNP
cord-006229-7yoilsho	1366	9	recruitment	recruitment	NN
cord-006229-7yoilsho	1366	10	was	be	VBD
cord-006229-7yoilsho	1366	11	strongly	strongly	RB
cord-006229-7yoilsho	1366	12	inhibited	inhibit	VBN
cord-006229-7yoilsho	1366	13	by	by	IN
cord-006229-7yoilsho	1366	14	siRNA	siRNA	NNP
cord-006229-7yoilsho	1366	15	knock	knock	VB
cord-006229-7yoilsho	1366	16	down	down	IN
cord-006229-7yoilsho	1366	17	of	of	IN
cord-006229-7yoilsho	1366	18	GRK2	GRK2	NNP
cord-006229-7yoilsho	1366	19	or	or	CC
cord-006229-7yoilsho	1366	20	GRK3	GRK3	NNP
cord-006229-7yoilsho	1366	21	.	.	.
cord-006229-7yoilsho	1367	1	Conversely	conversely	RB
cord-006229-7yoilsho	1367	2	,	,	,
cord-006229-7yoilsho	1367	3	the	the	DT
cord-006229-7yoilsho	1367	4	morphine	morphine	NN
cord-006229-7yoilsho	1367	5	-	-	HYPH
cord-006229-7yoilsho	1367	6	induced	induce	VBN
cord-006229-7yoilsho	1367	7	β	β	NN
cord-006229-7yoilsho	1367	8	-	-	HYPH
cord-006229-7yoilsho	1367	9	arrestin	arrestin	NNP
cord-006229-7yoilsho	1367	10	recruitment	recruitment	NN
cord-006229-7yoilsho	1367	11	was	be	VBD
cord-006229-7yoilsho	1367	12	strongly	strongly	RB
cord-006229-7yoilsho	1367	13	enhanced	enhance	VBN
cord-006229-7yoilsho	1367	14	by	by	IN
cord-006229-7yoilsho	1367	15	overexpression	overexpression	NN
cord-006229-7yoilsho	1367	16	of	of	IN
cord-006229-7yoilsho	1367	17	GRK2	GRK2	NNP
cord-006229-7yoilsho	1367	18	or	or	CC
cord-006229-7yoilsho	1367	19	GRK3	GRK3	NNP
cord-006229-7yoilsho	1367	20	.	.	.
cord-006229-7yoilsho	1368	1	Mutation	mutation	NN
cord-006229-7yoilsho	1368	2	of	of	IN
cord-006229-7yoilsho	1368	3	S375	S375	NNPS
cord-006229-7yoilsho	1368	4	to	to	IN
cord-006229-7yoilsho	1368	5	alanine	alanine	NN
cord-006229-7yoilsho	1368	6	strongly	strongly	RB
cord-006229-7yoilsho	1368	7	inhibited	inhibit	VBD
cord-006229-7yoilsho	1368	8	both	both	CC
cord-006229-7yoilsho	1368	9	GRK	GRK	NNPS
cord-006229-7yoilsho	1368	10	and	and	CC
cord-006229-7yoilsho	1368	11	β	β	NN
cord-006229-7yoilsho	1368	12	-	-	HYPH
cord-006229-7yoilsho	1368	13	arrestin	arrestin	NNP
cord-006229-7yoilsho	1368	14	recruitment	recruitment	NN
cord-006229-7yoilsho	1368	15	.	.	.
cord-006229-7yoilsho	1369	1	However	however	RB
cord-006229-7yoilsho	1369	2	,	,	,
cord-006229-7yoilsho	1369	3	mutation	mutation	NN
cord-006229-7yoilsho	1369	4	of	of	IN
cord-006229-7yoilsho	1369	5	all	all	DT
cord-006229-7yoilsho	1369	6	11	11	CD
cord-006229-7yoilsho	1369	7	carboxyl	carboxyl	NN
cord-006229-7yoilsho	1369	8	-	-	HYPH
cord-006229-7yoilsho	1369	9	terminal	terminal	NN
cord-006229-7yoilsho	1369	10	serine	serine	NN
cord-006229-7yoilsho	1369	11	and	and	CC
cord-006229-7yoilsho	1369	12	threonine	threonine	NN
cord-006229-7yoilsho	1369	13	residues	residue	NNS
cord-006229-7yoilsho	1369	14	of	of	IN
cord-006229-7yoilsho	1369	15	MOR	MOR	NNP
cord-006229-7yoilsho	1369	16	was	be	VBD
cord-006229-7yoilsho	1369	17	required	require	VBN
cord-006229-7yoilsho	1369	18	to	to	TO
cord-006229-7yoilsho	1369	19	completely	completely	RB
cord-006229-7yoilsho	1369	20	abolish	abolish	VB
cord-006229-7yoilsho	1369	21	its	-PRON-	PRP$
cord-006229-7yoilsho	1369	22	interaction	interaction	NN
cord-006229-7yoilsho	1369	23	with	with	IN
cord-006229-7yoilsho	1369	24	arrestins	arrestin	NNS
cord-006229-7yoilsho	1369	25	and	and	CC
cord-006229-7yoilsho	1369	26	GRKs	grk	NNS
cord-006229-7yoilsho	1369	27	resulting	result	VBG
cord-006229-7yoilsho	1369	28	in	in	IN
cord-006229-7yoilsho	1369	29	a	a	DT
cord-006229-7yoilsho	1369	30	complete	complete	JJ
cord-006229-7yoilsho	1369	31	loss	loss	NN
cord-006229-7yoilsho	1369	32	of	of	IN
cord-006229-7yoilsho	1369	33	MOR	MOR	NNP
cord-006229-7yoilsho	1369	34	internalization	internalization	NN
cord-006229-7yoilsho	1369	35	and	and	CC
cord-006229-7yoilsho	1369	36	desensitization	desensitization	NN
cord-006229-7yoilsho	1369	37	.	.	.
cord-006229-7yoilsho	1370	1	Heterotrimeric	heterotrimeric	NN
cord-006229-7yoilsho	1370	2	G	g	NN
cord-006229-7yoilsho	1370	3	proteins	protein	NNS
cord-006229-7yoilsho	1370	4	are	be	VBP
cord-006229-7yoilsho	1370	5	located	locate	VBN
cord-006229-7yoilsho	1370	6	at	at	IN
cord-006229-7yoilsho	1370	7	the	the	DT
cord-006229-7yoilsho	1370	8	inner	inner	JJ
cord-006229-7yoilsho	1370	9	leaflet	leaflet	NN
cord-006229-7yoilsho	1370	10	of	of	IN
cord-006229-7yoilsho	1370	11	plasma	plasma	NN
cord-006229-7yoilsho	1370	12	membranes	membrane	NNS
cord-006229-7yoilsho	1370	13	and	and	CC
cord-006229-7yoilsho	1370	14	are	be	VBP
cord-006229-7yoilsho	1370	15	a	a	DT
cord-006229-7yoilsho	1370	16	major	major	JJ
cord-006229-7yoilsho	1370	17	primary	primary	JJ
cord-006229-7yoilsho	1370	18	transducer	transducer	NN
cord-006229-7yoilsho	1370	19	of	of	IN
cord-006229-7yoilsho	1370	20	cell	cell	NN
cord-006229-7yoilsho	1370	21	signaling	signaling	NN
cord-006229-7yoilsho	1370	22	initiated	initiate	VBN
cord-006229-7yoilsho	1370	23	by	by	IN
cord-006229-7yoilsho	1370	24	G	g	NN
cord-006229-7yoilsho	1370	25	protein	protein	NN
cord-006229-7yoilsho	1370	26	-	-	HYPH
cord-006229-7yoilsho	1370	27	coupled	couple	VBN
cord-006229-7yoilsho	1370	28	receptors	receptor	NNS
cord-006229-7yoilsho	1370	29	(	(	-LRB-
cord-006229-7yoilsho	1370	30	GPCRs	GPCRs	NNP
cord-006229-7yoilsho	1370	31	)	)	-RRB-
cord-006229-7yoilsho	1370	32	.	.	.
cord-006229-7yoilsho	1371	1	Based	base	VBN
cord-006229-7yoilsho	1371	2	on	on	IN
cord-006229-7yoilsho	1371	3	sequence	sequence	NN
cord-006229-7yoilsho	1371	4	similarity	similarity	NN
cord-006229-7yoilsho	1371	5	,	,	,
cord-006229-7yoilsho	1371	6	heterotrimeric	heterotrimeric	NN
cord-006229-7yoilsho	1371	7	G	g	NN
cord-006229-7yoilsho	1371	8	proteins	protein	NNS
cord-006229-7yoilsho	1371	9	can	can	MD
cord-006229-7yoilsho	1371	10	be	be	VB
cord-006229-7yoilsho	1371	11	subdivided	subdivide	VBN
cord-006229-7yoilsho	1371	12	into	into	IN
cord-006229-7yoilsho	1371	13	four	four	CD
cord-006229-7yoilsho	1371	14	main	main	JJ
cord-006229-7yoilsho	1371	15	classes	class	NNS
cord-006229-7yoilsho	1371	16	,	,	,
cord-006229-7yoilsho	1371	17	i.e.	i.e.	FW
cord-006229-7yoilsho	1371	18	Gi	Gi	NNP
cord-006229-7yoilsho	1371	19	/	/	SYM
cord-006229-7yoilsho	1371	20	o	o	NN
cord-006229-7yoilsho	1371	21	,	,	,
cord-006229-7yoilsho	1371	22	Gs	Gs	NNP
cord-006229-7yoilsho	1371	23	,	,	,
cord-006229-7yoilsho	1371	24	Gq/11	Gq/11	NNP
cord-006229-7yoilsho	1371	25	,	,	,
cord-006229-7yoilsho	1371	26	and	and	CC
cord-006229-7yoilsho	1371	27	G12/13	g12/13	NN
cord-006229-7yoilsho	1371	28	,	,	,
cord-006229-7yoilsho	1371	29	which	which	WDT
cord-006229-7yoilsho	1371	30	interact	interact	VBP
cord-006229-7yoilsho	1371	31	with	with	IN
cord-006229-7yoilsho	1371	32	distinct	distinct	JJ
cord-006229-7yoilsho	1371	33	cellular	cellular	JJ
cord-006229-7yoilsho	1371	34	effectors	effector	NNS
cord-006229-7yoilsho	1371	35	to	to	TO
cord-006229-7yoilsho	1371	36	shape	shape	VB
cord-006229-7yoilsho	1371	37	the	the	DT
cord-006229-7yoilsho	1371	38	final	final	JJ
cord-006229-7yoilsho	1371	39	cellular	cellular	JJ
cord-006229-7yoilsho	1371	40	response	response	NN
cord-006229-7yoilsho	1371	41	1	1	CD
cord-006229-7yoilsho	1371	42	.	.	.
cord-006229-7yoilsho	1372	1	Identification	identification	NN
cord-006229-7yoilsho	1372	2	of	of	IN
cord-006229-7yoilsho	1372	3	new	new	JJ
cord-006229-7yoilsho	1372	4	selective	selective	JJ
cord-006229-7yoilsho	1372	5	and	and	CC
cord-006229-7yoilsho	1372	6	cell	cell	NN
cord-006229-7yoilsho	1372	7	-	-	HYPH
cord-006229-7yoilsho	1372	8	permeable	permeable	JJ
cord-006229-7yoilsho	1372	9	G	g	NN
cord-006229-7yoilsho	1372	10	protein	protein	NN
cord-006229-7yoilsho	1372	11	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	1372	12	is	be	VBZ
cord-006229-7yoilsho	1372	13	of	of	IN
cord-006229-7yoilsho	1372	14	great	great	JJ
cord-006229-7yoilsho	1372	15	interest	interest	NN
cord-006229-7yoilsho	1372	16	as	as	IN
cord-006229-7yoilsho	1372	17	these	these	DT
cord-006229-7yoilsho	1372	18	may	may	MD
cord-006229-7yoilsho	1372	19	be	be	VB
cord-006229-7yoilsho	1372	20	beneficial	beneficial	JJ
cord-006229-7yoilsho	1372	21	in	in	IN
cord-006229-7yoilsho	1372	22	complex	complex	JJ
cord-006229-7yoilsho	1372	23	pathologies	pathology	NNS
cord-006229-7yoilsho	1372	24	that	that	WDT
cord-006229-7yoilsho	1372	25	involve	involve	VBP
cord-006229-7yoilsho	1372	26	signaling	signal	VBG
cord-006229-7yoilsho	1372	27	of	of	IN
cord-006229-7yoilsho	1372	28	multiple	multiple	JJ
cord-006229-7yoilsho	1372	29	GPCRs	gpcr	NNS
cord-006229-7yoilsho	1372	30	2	2	CD
cord-006229-7yoilsho	1372	31	.	.	.
cord-006229-7yoilsho	1373	1	Mechanistically	mechanistically	RB
cord-006229-7yoilsho	1373	2	,	,	,
cord-006229-7yoilsho	1373	3	small	small	JJ
cord-006229-7yoilsho	1373	4	molecule	molecule	NN
cord-006229-7yoilsho	1373	5	G	g	NN
cord-006229-7yoilsho	1373	6	protein	protein	NN
cord-006229-7yoilsho	1373	7	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	1373	8	may	may	MD
cord-006229-7yoilsho	1373	9	,	,	,
cord-006229-7yoilsho	1373	10	for	for	IN
cord-006229-7yoilsho	1373	11	instance	instance	NN
cord-006229-7yoilsho	1373	12	,	,	,
cord-006229-7yoilsho	1373	13	block	block	NN
cord-006229-7yoilsho	1373	14	nucleotide	nucleotide	JJ
cord-006229-7yoilsho	1373	15	exchange	exchange	NN
cord-006229-7yoilsho	1373	16	by	by	IN
cord-006229-7yoilsho	1373	17	inhibiting	inhibit	VBG
cord-006229-7yoilsho	1373	18	GDP	GDP	NNP
cord-006229-7yoilsho	1373	19	release	release	NN
cord-006229-7yoilsho	1373	20	(	(	-LRB-
cord-006229-7yoilsho	1373	21	i.e.	i.e.	FW
cord-006229-7yoilsho	1373	22	guanyl	guanyl	NN
cord-006229-7yoilsho	1373	23	nucleotide	nucleotide	JJ
cord-006229-7yoilsho	1373	24	dissociation	dissociation	NN
cord-006229-7yoilsho	1373	25	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	1373	26	,	,	,
cord-006229-7yoilsho	1373	27	GDIs	gdi	NNS
cord-006229-7yoilsho	1373	28	)	)	-RRB-
cord-006229-7yoilsho	1373	29	or	or	CC
cord-006229-7yoilsho	1373	30	allow	allow	VB
cord-006229-7yoilsho	1373	31	GDP	GDP	NNP
cord-006229-7yoilsho	1373	32	release	release	NN
cord-006229-7yoilsho	1373	33	but	but	CC
cord-006229-7yoilsho	1373	34	block	block	NN
cord-006229-7yoilsho	1373	35	GTP	GTP	NNP
cord-006229-7yoilsho	1373	36	entry	entry	NN
cord-006229-7yoilsho	1373	37	by	by	IN
cord-006229-7yoilsho	1373	38	stabilizing	stabilize	VBG
cord-006229-7yoilsho	1373	39	the	the	DT
cord-006229-7yoilsho	1373	40	G	g	NN
cord-006229-7yoilsho	1373	41	protein	protein	NN
cord-006229-7yoilsho	1373	42	in	in	IN
cord-006229-7yoilsho	1373	43	an	an	DT
cord-006229-7yoilsho	1373	44	empty	empty	JJ
cord-006229-7yoilsho	1373	45	pocket	pocket	NN
cord-006229-7yoilsho	1373	46	conformation	conformation	NN
cord-006229-7yoilsho	1373	47	3	3	CD
cord-006229-7yoilsho	1373	48	.	.	.
cord-006229-7yoilsho	1374	1	Here	here	RB
cord-006229-7yoilsho	1374	2	,	,	,
cord-006229-7yoilsho	1374	3	we	-PRON-	PRP
cord-006229-7yoilsho	1374	4	set	set	VBD
cord-006229-7yoilsho	1374	5	out	out	RP
cord-006229-7yoilsho	1374	6	a	a	DT
cord-006229-7yoilsho	1374	7	new	new	JJ
cord-006229-7yoilsho	1374	8	approach	approach	NN
cord-006229-7yoilsho	1374	9	to	to	TO
cord-006229-7yoilsho	1374	10	classify	classify	VB
cord-006229-7yoilsho	1374	11	G	g	NN
cord-006229-7yoilsho	1374	12	protein	protein	NN
cord-006229-7yoilsho	1374	13	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	1374	14	regarding	regard	VBG
cord-006229-7yoilsho	1374	15	their	-PRON-	PRP$
cord-006229-7yoilsho	1374	16	mechanism	mechanism	NN
cord-006229-7yoilsho	1374	17	of	of	IN
cord-006229-7yoilsho	1374	18	action	action	NN
cord-006229-7yoilsho	1374	19	in	in	IN
cord-006229-7yoilsho	1374	20	radioligand	radioligand	JJ
cord-006229-7yoilsho	1374	21	binding	bind	VBG
cord-006229-7yoilsho	1374	22	experiments	experiment	NNS
cord-006229-7yoilsho	1374	23	.	.	.
cord-006229-7yoilsho	1375	1	In	in	IN
cord-006229-7yoilsho	1375	2	particular	particular	JJ
cord-006229-7yoilsho	1375	3	,	,	,
cord-006229-7yoilsho	1375	4	we	-PRON-	PRP
cord-006229-7yoilsho	1375	5	investigated	investigate	VBD
cord-006229-7yoilsho	1375	6	the	the	DT
cord-006229-7yoilsho	1375	7	influence	influence	NN
cord-006229-7yoilsho	1375	8	of	of	IN
cord-006229-7yoilsho	1375	9	the	the	DT
cord-006229-7yoilsho	1375	10	specific	specific	JJ
cord-006229-7yoilsho	1375	11	Gα	Gα	NNP
cord-006229-7yoilsho	1375	12	q/11/14	q/11/14	NNP
cord-006229-7yoilsho	1375	13	inhibitor	inhibitor	NN
cord-006229-7yoilsho	1375	14	FR900359	fr900359	NN
cord-006229-7yoilsho	1375	15	4	4	CD
cord-006229-7yoilsho	1375	16	on	on	IN
cord-006229-7yoilsho	1375	17	agonist	agonist	NN
cord-006229-7yoilsho	1375	18	-	-	HYPH
cord-006229-7yoilsho	1375	19	radioantagonist	radioantagonist	NN
cord-006229-7yoilsho	1375	20	binding	bind	VBG
cord-006229-7yoilsho	1375	21	experiments	experiment	NNS
cord-006229-7yoilsho	1375	22	performed	perform	VBN
cord-006229-7yoilsho	1375	23	with	with	IN
cord-006229-7yoilsho	1375	24	membranes	membrane	NNS
cord-006229-7yoilsho	1375	25	of	of	IN
cord-006229-7yoilsho	1375	26	CHO	CHO	NNP
cord-006229-7yoilsho	1375	27	cells	cell	NNS
cord-006229-7yoilsho	1375	28	stably	stably	RB
cord-006229-7yoilsho	1375	29	expressing	express	VBG
cord-006229-7yoilsho	1375	30	the	the	DT
cord-006229-7yoilsho	1375	31	muscarinic	muscarinic	JJ
cord-006229-7yoilsho	1375	32	M1	M1	NNP
cord-006229-7yoilsho	1375	33	acetylcholine	acetylcholine	NN
cord-006229-7yoilsho	1375	34	receptor	receptor	NN
cord-006229-7yoilsho	1375	35	(	(	-LRB-
cord-006229-7yoilsho	1375	36	CHO	CHO	NNP
cord-006229-7yoilsho	1375	37	-	-	HYPH
cord-006229-7yoilsho	1375	38	M1	M1	NNP
cord-006229-7yoilsho	1375	39	)	)	-RRB-
cord-006229-7yoilsho	1375	40	.	.	.
cord-006229-7yoilsho	1376	1	Agonistradioantagonist	agonistradioantagonist	NN
cord-006229-7yoilsho	1376	2	competition	competition	NN
cord-006229-7yoilsho	1376	3	under	under	IN
cord-006229-7yoilsho	1376	4	these	these	DT
cord-006229-7yoilsho	1376	5	conditions	condition	NNS
cord-006229-7yoilsho	1376	6	is	be	VBZ
cord-006229-7yoilsho	1376	7	biphasic	biphasic	JJ
cord-006229-7yoilsho	1376	8	because	because	IN
cord-006229-7yoilsho	1376	9	agonists	agonist	NNS
cord-006229-7yoilsho	1376	10	bind	bind	VBP
cord-006229-7yoilsho	1376	11	with	with	IN
cord-006229-7yoilsho	1376	12	higher	high	JJR
cord-006229-7yoilsho	1376	13	affinity	affinity	NN
cord-006229-7yoilsho	1376	14	in	in	IN
cord-006229-7yoilsho	1376	15	the	the	DT
cord-006229-7yoilsho	1376	16	ternary	ternary	JJ
cord-006229-7yoilsho	1376	17	complex	complex	NN
cord-006229-7yoilsho	1376	18	consisting	consisting	NN
cord-006229-7yoilsho	1376	19	of	of	IN
cord-006229-7yoilsho	1376	20	agonist	agonist	NN
cord-006229-7yoilsho	1376	21	,	,	,
cord-006229-7yoilsho	1376	22	receptor	receptor	NN
cord-006229-7yoilsho	1376	23	and	and	CC
cord-006229-7yoilsho	1376	24	nucleotidefree	nucleotidefree	NNP
cord-006229-7yoilsho	1376	25	G	G	NNP
cord-006229-7yoilsho	1376	26	protein	protein	NN
cord-006229-7yoilsho	1376	27	compared	compare	VBN
cord-006229-7yoilsho	1376	28	with	with	IN
cord-006229-7yoilsho	1376	29	a	a	DT
cord-006229-7yoilsho	1376	30	G	g	NN
cord-006229-7yoilsho	1376	31	protein	protein	NN
cord-006229-7yoilsho	1376	32	-	-	HYPH
cord-006229-7yoilsho	1376	33	free	free	JJ
cord-006229-7yoilsho	1376	34	receptor	receptor	NN
cord-006229-7yoilsho	1376	35	1,5	1,5	CD
cord-006229-7yoilsho	1376	36	.	.	.
cord-006229-7yoilsho	1377	1	We	-PRON-	PRP
cord-006229-7yoilsho	1377	2	show	show	VBP
cord-006229-7yoilsho	1377	3	that	that	IN
cord-006229-7yoilsho	1377	4	FR900359	fr900359	NN
cord-006229-7yoilsho	1377	5	can	can	MD
cord-006229-7yoilsho	1377	6	be	be	VB
cord-006229-7yoilsho	1377	7	classified	classify	VBN
cord-006229-7yoilsho	1377	8	as	as	IN
cord-006229-7yoilsho	1377	9	a	a	DT
cord-006229-7yoilsho	1377	10	GDI	GDI	NNP
cord-006229-7yoilsho	1377	11	as	as	IN
cord-006229-7yoilsho	1377	12	it	-PRON-	PRP
cord-006229-7yoilsho	1377	13	significantly	significantly	RB
cord-006229-7yoilsho	1377	14	reduced	reduce	VBD
cord-006229-7yoilsho	1377	15	high	high	JJ
cord-006229-7yoilsho	1377	16	affinity	affinity	NN
cord-006229-7yoilsho	1377	17	binding	binding	NN
cord-006229-7yoilsho	1377	18	of	of	IN
cord-006229-7yoilsho	1377	19	carbachol	carbachol	NN
cord-006229-7yoilsho	1377	20	in	in	IN
cord-006229-7yoilsho	1377	21	CHO	CHO	NNP
cord-006229-7yoilsho	1377	22	-	-	HYPH
cord-006229-7yoilsho	1377	23	M1	M1	NNP
cord-006229-7yoilsho	1377	24	membranes	membrane	NNS
cord-006229-7yoilsho	1377	25	.	.	.
cord-006229-7yoilsho	1378	1	In	in	IN
cord-006229-7yoilsho	1378	2	contrast	contrast	NN
cord-006229-7yoilsho	1378	3	to	to	IN
cord-006229-7yoilsho	1378	4	this	this	DT
cord-006229-7yoilsho	1378	5	,	,	,
cord-006229-7yoilsho	1378	6	BIM-46187	BIM-46187	NNP
cord-006229-7yoilsho	1378	7	,	,	,
cord-006229-7yoilsho	1378	8	a	a	DT
cord-006229-7yoilsho	1378	9	pan	pan	NN
cord-006229-7yoilsho	1378	10	G	G	NNP
cord-006229-7yoilsho	1378	11	protein	protein	NN
cord-006229-7yoilsho	1378	12	inhibitor	inhibitor	NN
cord-006229-7yoilsho	1378	13	with	with	IN
cord-006229-7yoilsho	1378	14	a	a	DT
cord-006229-7yoilsho	1378	15	cell	cell	NN
cord-006229-7yoilsho	1378	16	-	-	HYPH
cord-006229-7yoilsho	1378	17	type	type	NN
cord-006229-7yoilsho	1378	18	-	-	HYPH
cord-006229-7yoilsho	1378	19	dependent	dependent	JJ
cord-006229-7yoilsho	1378	20	preference	preference	NN
cord-006229-7yoilsho	1378	21	for	for	IN
cord-006229-7yoilsho	1378	22	Gq	Gq	NNP
cord-006229-7yoilsho	1378	23	,	,	,
cord-006229-7yoilsho	1378	24	did	do	VBD
cord-006229-7yoilsho	1378	25	not	not	RB
cord-006229-7yoilsho	1378	26	influence	influence	VB
cord-006229-7yoilsho	1378	27	high	high	JJ
cord-006229-7yoilsho	1378	28	affinity	affinity	NN
cord-006229-7yoilsho	1378	29	agonist	agonist	NN
cord-006229-7yoilsho	1378	30	binding	binding	NN
cord-006229-7yoilsho	1378	31	and	and	CC
cord-006229-7yoilsho	1378	32	thus	thus	RB
cord-006229-7yoilsho	1378	33	stabilized	stabilize	VBD
cord-006229-7yoilsho	1378	34	Gq	Gq	NNP
cord-006229-7yoilsho	1378	35	in	in	IN
cord-006229-7yoilsho	1378	36	an	an	DT
cord-006229-7yoilsho	1378	37	empty	empty	JJ
cord-006229-7yoilsho	1378	38	pocket	pocket	NN
cord-006229-7yoilsho	1378	39	conformation	conformation	NN
cord-006229-7yoilsho	1378	40	3	3	CD
cord-006229-7yoilsho	1378	41	.	.	.
cord-006229-7yoilsho	1379	1	Interestingly	interestingly	RB
cord-006229-7yoilsho	1379	2	,	,	,
cord-006229-7yoilsho	1379	3	inhibition	inhibition	NN
cord-006229-7yoilsho	1379	4	of	of	IN
cord-006229-7yoilsho	1379	5	high	high	JJ
cord-006229-7yoilsho	1379	6	affinity	affinity	NN
cord-006229-7yoilsho	1379	7	agonist	agonist	NN
cord-006229-7yoilsho	1379	8	binding	bind	VBG
cord-006229-7yoilsho	1379	9	by	by	IN
cord-006229-7yoilsho	1379	10	FR900359	fr900359	NN
cord-006229-7yoilsho	1379	11	was	be	VBD
cord-006229-7yoilsho	1379	12	incomplete	incomplete	JJ
cord-006229-7yoilsho	1379	13	in	in	IN
cord-006229-7yoilsho	1379	14	agonist	agonist	NN
cord-006229-7yoilsho	1379	15	-	-	HYPH
cord-006229-7yoilsho	1379	16	radioantagonist	radioantagonist	NN
cord-006229-7yoilsho	1379	17	displacement	displacement	NN
cord-006229-7yoilsho	1379	18	studies	study	NNS
cord-006229-7yoilsho	1379	19	and	and	CC
cord-006229-7yoilsho	1379	20	also	also	RB
cord-006229-7yoilsho	1379	21	when	when	WRB
cord-006229-7yoilsho	1379	22	a	a	DT
cord-006229-7yoilsho	1379	23	radioagonist	radioagonist	NN
cord-006229-7yoilsho	1379	24	was	be	VBD
cord-006229-7yoilsho	1379	25	applied	apply	VBN
cord-006229-7yoilsho	1379	26	.	.	.
cord-006229-7yoilsho	1380	1	To	to	TO
cord-006229-7yoilsho	1380	2	fully	fully	RB
cord-006229-7yoilsho	1380	3	prevent	prevent	VB
cord-006229-7yoilsho	1380	4	high	high	JJ
cord-006229-7yoilsho	1380	5	affinity	affinity	NN
cord-006229-7yoilsho	1380	6	agonist	agonist	NN
cord-006229-7yoilsho	1380	7	binding	bind	VBG
cord-006229-7yoilsho	1380	8	by	by	IN
cord-006229-7yoilsho	1380	9	FR900359	fr900359	NN
cord-006229-7yoilsho	1380	10	,	,	,
cord-006229-7yoilsho	1380	11	combined	combine	VBN
cord-006229-7yoilsho	1380	12	uncoupling	uncoupling	NN
cord-006229-7yoilsho	1380	13	of	of	IN
cord-006229-7yoilsho	1380	14	both	both	DT
cord-006229-7yoilsho	1380	15	Gi	Gi	NNP
cord-006229-7yoilsho	1380	16	and	and	CC
cord-006229-7yoilsho	1380	17	Gs	Gs	NNP
cord-006229-7yoilsho	1380	18	proteins	protein	NNS
cord-006229-7yoilsho	1380	19	from	from	IN
cord-006229-7yoilsho	1380	20	M1	M1	NNP
cord-006229-7yoilsho	1380	21	was	be	VBD
cord-006229-7yoilsho	1380	22	required	require	VBN
cord-006229-7yoilsho	1380	23	by	by	IN
cord-006229-7yoilsho	1380	24	pre	pre	JJ
cord-006229-7yoilsho	1380	25	-	-	NN
cord-006229-7yoilsho	1380	26	treatment	treatment	JJ
cord-006229-7yoilsho	1380	27	with	with	IN
cord-006229-7yoilsho	1380	28	pertussis	pertussis	NN
cord-006229-7yoilsho	1380	29	toxin	toxin	NN
cord-006229-7yoilsho	1380	30	and	and	CC
cord-006229-7yoilsho	1380	31	cholera	cholera	NN
cord-006229-7yoilsho	1380	32	toxin	toxin	NN
cord-006229-7yoilsho	1380	33	,	,	,
cord-006229-7yoilsho	1380	34	respectively	respectively	RB
cord-006229-7yoilsho	1380	35	.	.	.
cord-006229-7yoilsho	1381	1	These	these	DT
cord-006229-7yoilsho	1381	2	data	datum	NNS
cord-006229-7yoilsho	1381	3	demonstrate	demonstrate	VBP
cord-006229-7yoilsho	1381	4	that	that	IN
cord-006229-7yoilsho	1381	5	not	not	RB
cord-006229-7yoilsho	1381	6	only	only	RB
cord-006229-7yoilsho	1381	7	Gq	Gq	NNP
cord-006229-7yoilsho	1381	8	,	,	,
cord-006229-7yoilsho	1381	9	but	but	CC
cord-006229-7yoilsho	1381	10	also	also	RB
cord-006229-7yoilsho	1381	11	Gi	Gi	NNP
cord-006229-7yoilsho	1381	12	,	,	,
cord-006229-7yoilsho	1381	13	and	and	CC
cord-006229-7yoilsho	1381	14	Gs	Gs	NNP
cord-006229-7yoilsho	1381	15	,	,	,
cord-006229-7yoilsho	1381	16	contribute	contribute	VBP
cord-006229-7yoilsho	1381	17	to	to	IN
cord-006229-7yoilsho	1381	18	the	the	DT
cord-006229-7yoilsho	1381	19	high	high	JJ
cord-006229-7yoilsho	1381	20	affinity	affinity	NN
cord-006229-7yoilsho	1381	21	fraction	fraction	NN
cord-006229-7yoilsho	1381	22	of	of	IN
cord-006229-7yoilsho	1381	23	M1	M1	NNP
cord-006229-7yoilsho	1381	24	receptors	receptor	NNS
cord-006229-7yoilsho	1381	25	.	.	.
cord-006229-7yoilsho	1382	1	Taken	take	VBN
cord-006229-7yoilsho	1382	2	together	together	RB
cord-006229-7yoilsho	1382	3	,	,	,
cord-006229-7yoilsho	1382	4	our	-PRON-	PRP$
cord-006229-7yoilsho	1382	5	findings	finding	NNS
cord-006229-7yoilsho	1382	6	show	show	VBP
cord-006229-7yoilsho	1382	7	that	that	IN
cord-006229-7yoilsho	1382	8	radioligand	radioligand	VBP
cord-006229-7yoilsho	1382	9	binding	bind	VBG
cord-006229-7yoilsho	1382	10	experiments	experiment	NNS
cord-006229-7yoilsho	1382	11	are	be	VBP
cord-006229-7yoilsho	1382	12	an	an	DT
cord-006229-7yoilsho	1382	13	attractive	attractive	JJ
cord-006229-7yoilsho	1382	14	approach	approach	NN
cord-006229-7yoilsho	1382	15	to	to	TO
cord-006229-7yoilsho	1382	16	classify	classify	VB
cord-006229-7yoilsho	1382	17	new	new	JJ
cord-006229-7yoilsho	1382	18	G	g	NN
cord-006229-7yoilsho	1382	19	protein	protein	NN
cord-006229-7yoilsho	1382	20	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	1382	21	according	accord	VBG
cord-006229-7yoilsho	1382	22	to	to	IN
cord-006229-7yoilsho	1382	23	their	-PRON-	PRP$
cord-006229-7yoilsho	1382	24	mechanism	mechanism	NN
cord-006229-7yoilsho	1382	25	of	of	IN
cord-006229-7yoilsho	1382	26	action	action	NN
cord-006229-7yoilsho	1382	27	.	.	.
cord-006229-7yoilsho	1383	1	Universität	Universität	NNP
cord-006229-7yoilsho	1383	2	,	,	,
cord-006229-7yoilsho	1383	3	Würzburg	Würzburg	NNP
cord-006229-7yoilsho	1383	4	,	,	,
cord-006229-7yoilsho	1383	5	Germany	Germany	NNP
cord-006229-7yoilsho	1383	6	G	G	NNP
cord-006229-7yoilsho	1383	7	protein	protein	NN
cord-006229-7yoilsho	1383	8	-	-	HYPH
cord-006229-7yoilsho	1383	9	coupled	couple	VBN
cord-006229-7yoilsho	1383	10	receptors	receptor	NNS
cord-006229-7yoilsho	1383	11	(	(	-LRB-
cord-006229-7yoilsho	1383	12	GPCRs	GPCRs	NNP
cord-006229-7yoilsho	1383	13	)	)	-RRB-
cord-006229-7yoilsho	1383	14	are	be	VBP
cord-006229-7yoilsho	1383	15	cell	cell	NN
cord-006229-7yoilsho	1383	16	surface	surface	NN
cord-006229-7yoilsho	1383	17	receptors	receptor	NNS
cord-006229-7yoilsho	1383	18	which	which	WDT
cord-006229-7yoilsho	1383	19	,	,	,
cord-006229-7yoilsho	1383	20	upon	upon	IN
cord-006229-7yoilsho	1383	21	a	a	DT
cord-006229-7yoilsho	1383	22	conformational	conformational	JJ
cord-006229-7yoilsho	1383	23	change	change	NN
cord-006229-7yoilsho	1383	24	in	in	IN
cord-006229-7yoilsho	1383	25	the	the	DT
cord-006229-7yoilsho	1383	26	receptor	receptor	NN
cord-006229-7yoilsho	1383	27	protein	protein	NN
cord-006229-7yoilsho	1383	28	induced	induce	VBN
cord-006229-7yoilsho	1383	29	by	by	IN
cord-006229-7yoilsho	1383	30	an	an	DT
cord-006229-7yoilsho	1383	31	extracellular	extracellular	JJ
cord-006229-7yoilsho	1383	32	stimulus	stimulus	NN
cord-006229-7yoilsho	1383	33	,	,	,
cord-006229-7yoilsho	1383	34	can	can	MD
cord-006229-7yoilsho	1383	35	transduce	transduce	VB
cord-006229-7yoilsho	1383	36	the	the	DT
cord-006229-7yoilsho	1383	37	signal	signal	NN
cord-006229-7yoilsho	1383	38	onto	onto	IN
cord-006229-7yoilsho	1383	39	intracellular	intracellular	JJ
cord-006229-7yoilsho	1383	40	adaptor	adaptor	NN
cord-006229-7yoilsho	1383	41	proteins	protein	NNS
cord-006229-7yoilsho	1383	42	such	such	JJ
cord-006229-7yoilsho	1383	43	as	as	IN
cord-006229-7yoilsho	1383	44	heterotrimeric	heterotrimeric	NNP
cord-006229-7yoilsho	1383	45	G	g	NN
cord-006229-7yoilsho	1383	46	proteins	protein	NNS
cord-006229-7yoilsho	1383	47	[	[	-LRB-
cord-006229-7yoilsho	1383	48	1	1	CD
cord-006229-7yoilsho	1383	49	]	]	-RRB-
cord-006229-7yoilsho	1383	50	.	.	.
cord-006229-7yoilsho	1384	1	GPCR	GPCR	NNP
cord-006229-7yoilsho	1384	2	-	-	HYPH
cord-006229-7yoilsho	1384	3	induced	induce	VBN
cord-006229-7yoilsho	1384	4	cell	cell	NN
cord-006229-7yoilsho	1384	5	signaling	signaling	NN
cord-006229-7yoilsho	1384	6	can	can	MD
cord-006229-7yoilsho	1384	7	be	be	VB
cord-006229-7yoilsho	1384	8	rather	rather	RB
cord-006229-7yoilsho	1384	9	complex	complex	JJ
cord-006229-7yoilsho	1384	10	as	as	IN
cord-006229-7yoilsho	1384	11	several	several	JJ
cord-006229-7yoilsho	1384	12	GPCRs	gpcr	NNS
cord-006229-7yoilsho	1384	13	may	may	MD
cord-006229-7yoilsho	1384	14	activate	activate	VB
cord-006229-7yoilsho	1384	15	multiple	multiple	JJ
cord-006229-7yoilsho	1384	16	different	different	JJ
cord-006229-7yoilsho	1384	17	adaptor	adaptor	NN
cord-006229-7yoilsho	1384	18	proteins	protein	NNS
cord-006229-7yoilsho	1384	19	and	and	CC
cord-006229-7yoilsho	1384	20	can	can	MD
cord-006229-7yoilsho	1384	21	additionally	additionally	RB
cord-006229-7yoilsho	1384	22	be	be	VB
cord-006229-7yoilsho	1384	23	activated	activate	VBN
cord-006229-7yoilsho	1384	24	via	via	IN
cord-006229-7yoilsho	1384	25	distinct	distinct	JJ
cord-006229-7yoilsho	1384	26	binding	bind	VBG
cord-006229-7yoilsho	1384	27	sites	site	NNS
cord-006229-7yoilsho	1384	28	,	,	,
cord-006229-7yoilsho	1384	29	i.e.	i.e.	FW
cord-006229-7yoilsho	1384	30	the	the	DT
cord-006229-7yoilsho	1384	31	orthosteric	orthosteric	NNP
cord-006229-7yoilsho	1384	32	transmitter	transmitter	NN
cord-006229-7yoilsho	1384	33	binding	bind	VBG
cord-006229-7yoilsho	1384	34	site	site	NN
cord-006229-7yoilsho	1384	35	and	and	CC
cord-006229-7yoilsho	1384	36	other	other	JJ
cord-006229-7yoilsho	1384	37	"	"	``
cord-006229-7yoilsho	1384	38	allosteric	allosteric	JJ
cord-006229-7yoilsho	1384	39	"	"	''
cord-006229-7yoilsho	1384	40	binding	bind	VBG
cord-006229-7yoilsho	1384	41	sites	site	NNS
cord-006229-7yoilsho	1384	42	[	[	-LRB-
cord-006229-7yoilsho	1384	43	2	2	CD
cord-006229-7yoilsho	1384	44	]	]	-RRB-
cord-006229-7yoilsho	1384	45	.	.	.
cord-006229-7yoilsho	1385	1	In	in	IN
cord-006229-7yoilsho	1385	2	the	the	DT
cord-006229-7yoilsho	1385	3	present	present	JJ
cord-006229-7yoilsho	1385	4	work	work	NN
cord-006229-7yoilsho	1385	5	,	,	,
cord-006229-7yoilsho	1385	6	we	-PRON-	PRP
cord-006229-7yoilsho	1385	7	wanted	want	VBD
cord-006229-7yoilsho	1385	8	to	to	TO
cord-006229-7yoilsho	1385	9	investigate	investigate	VB
cord-006229-7yoilsho	1385	10	the	the	DT
cord-006229-7yoilsho	1385	11	influence	influence	NN
cord-006229-7yoilsho	1385	12	of	of	IN
cord-006229-7yoilsho	1385	13	an	an	DT
cord-006229-7yoilsho	1385	14	allosteric	allosteric	JJ
cord-006229-7yoilsho	1385	15	binding	binding	NN
cord-006229-7yoilsho	1385	16	site	site	NN
cord-006229-7yoilsho	1385	17	on	on	IN
cord-006229-7yoilsho	1385	18	receptor	receptor	NN
cord-006229-7yoilsho	1385	19	activation	activation	NN
cord-006229-7yoilsho	1385	20	of	of	IN
cord-006229-7yoilsho	1385	21	muscarinic	muscarinic	JJ
cord-006229-7yoilsho	1385	22	acetylcholine	acetylcholine	NN
cord-006229-7yoilsho	1385	23	receptors	receptor	NNS
cord-006229-7yoilsho	1385	24	(	(	-LRB-
cord-006229-7yoilsho	1385	25	mAChRs	machrs	NN
cord-006229-7yoilsho	1385	26	)	)	-RRB-
cord-006229-7yoilsho	1385	27	.	.	.
cord-006229-7yoilsho	1386	1	To	to	IN
cord-006229-7yoilsho	1386	2	this	this	DT
cord-006229-7yoilsho	1386	3	end	end	NN
cord-006229-7yoilsho	1386	4	,	,	,
cord-006229-7yoilsho	1386	5	we	-PRON-	PRP
cord-006229-7yoilsho	1386	6	employed	employ	VBD
cord-006229-7yoilsho	1386	7	the	the	DT
cord-006229-7yoilsho	1386	8	orthosteric	orthosteric	JJ
cord-006229-7yoilsho	1386	9	full	full	JJ
cord-006229-7yoilsho	1386	10	agonists	agonist	NNS
cord-006229-7yoilsho	1386	11	acetylcholine	acetylcholine	NN
cord-006229-7yoilsho	1386	12	and	and	CC
cord-006229-7yoilsho	1386	13	iperoxo	iperoxo	NNP
cord-006229-7yoilsho	1386	14	as	as	RB
cord-006229-7yoilsho	1386	15	well	well	RB
cord-006229-7yoilsho	1386	16	as	as	IN
cord-006229-7yoilsho	1386	17	several	several	JJ
cord-006229-7yoilsho	1386	18	dualsteric	dualsteric	JJ
cord-006229-7yoilsho	1386	19	compounds	compound	NNS
cord-006229-7yoilsho	1386	20	consisting	consist	VBG
cord-006229-7yoilsho	1386	21	of	of	IN
cord-006229-7yoilsho	1386	22	iperoxo	iperoxo	NNP
cord-006229-7yoilsho	1386	23	linked	link	VBN
cord-006229-7yoilsho	1386	24	to	to	IN
cord-006229-7yoilsho	1386	25	an	an	DT
cord-006229-7yoilsho	1386	26	allosteric	allosteric	JJ
cord-006229-7yoilsho	1386	27	phthalimide	phthalimide	NN
cord-006229-7yoilsho	1386	28	(	(	-LRB-
cord-006229-7yoilsho	1386	29	phth	phth	NNP
cord-006229-7yoilsho	1386	30	)	)	-RRB-
cord-006229-7yoilsho	1386	31	or	or	CC
cord-006229-7yoilsho	1386	32	naphthalimide	naphthalimide	NNP
cord-006229-7yoilsho	1386	33	(	(	-LRB-
cord-006229-7yoilsho	1386	34	naph	naph	NNP
cord-006229-7yoilsho	1386	35	)	)	-RRB-
cord-006229-7yoilsho	1386	36	moiety	moiety	VBZ
cord-006229-7yoilsho	1386	37	through	through	IN
cord-006229-7yoilsho	1386	38	alkyl	alkyl	JJ
cord-006229-7yoilsho	1386	39	chains	chain	NNS
cord-006229-7yoilsho	1386	40	of	of	IN
cord-006229-7yoilsho	1386	41	different	different	JJ
cord-006229-7yoilsho	1386	42	length	length	NN
cord-006229-7yoilsho	1386	43	or	or	CC
cord-006229-7yoilsho	1386	44	through	through	IN
cord-006229-7yoilsho	1386	45	a	a	DT
cord-006229-7yoilsho	1386	46	diamide	diamide	NN
cord-006229-7yoilsho	1386	47	linker	linker	NN
cord-006229-7yoilsho	1386	48	(	(	-LRB-
cord-006229-7yoilsho	1386	49	fri	fri	NNP
cord-006229-7yoilsho	1386	50	)	)	-RRB-
cord-006229-7yoilsho	1386	51	.	.	.
cord-006229-7yoilsho	1387	1	Binding	bind	VBG
cord-006229-7yoilsho	1387	2	of	of	IN
cord-006229-7yoilsho	1387	3	the	the	DT
cord-006229-7yoilsho	1387	4	allosteric	allosteric	JJ
cord-006229-7yoilsho	1387	5	part	part	NN
cord-006229-7yoilsho	1387	6	to	to	IN
cord-006229-7yoilsho	1387	7	the	the	DT
cord-006229-7yoilsho	1387	8	receptor	receptor	NN
cord-006229-7yoilsho	1387	9	protein	protein	NN
cord-006229-7yoilsho	1387	10	may	may	MD
cord-006229-7yoilsho	1387	11	restrict	restrict	VB
cord-006229-7yoilsho	1387	12	the	the	DT
cord-006229-7yoilsho	1387	13	conformational	conformational	JJ
cord-006229-7yoilsho	1387	14	flexibility	flexibility	NN
cord-006229-7yoilsho	1387	15	of	of	IN
cord-006229-7yoilsho	1387	16	the	the	DT
cord-006229-7yoilsho	1387	17	receptor	receptor	NN
cord-006229-7yoilsho	1387	18	protein	protein	NN
cord-006229-7yoilsho	1387	19	and	and	CC
cord-006229-7yoilsho	1387	20	thus	thus	RB
cord-006229-7yoilsho	1387	21	interfere	interfere	VB
cord-006229-7yoilsho	1387	22	with	with	IN
cord-006229-7yoilsho	1387	23	receptor	receptor	NN
cord-006229-7yoilsho	1387	24	activation	activation	NN
cord-006229-7yoilsho	1387	25	[	[	-LRB-
cord-006229-7yoilsho	1387	26	2	2	CD
cord-006229-7yoilsho	1387	27	]	]	-RRB-
cord-006229-7yoilsho	1387	28	.	.	.
cord-006229-7yoilsho	1388	1	Therefore	therefore	RB
cord-006229-7yoilsho	1388	2	,	,	,
cord-006229-7yoilsho	1388	3	application	application	NN
cord-006229-7yoilsho	1388	4	of	of	IN
cord-006229-7yoilsho	1388	5	different	different	JJ
cord-006229-7yoilsho	1388	6	linker	linker	NN
cord-006229-7yoilsho	1388	7	length	length	NN
cord-006229-7yoilsho	1388	8	may	may	MD
cord-006229-7yoilsho	1388	9	control	control	VB
cord-006229-7yoilsho	1388	10	the	the	DT
cord-006229-7yoilsho	1388	11	signaling	signal	VBG
cord-006229-7yoilsho	1388	12	outcome	outcome	NN
cord-006229-7yoilsho	1388	13	.	.	.
cord-006229-7yoilsho	1389	1	Here	here	RB
cord-006229-7yoilsho	1389	2	,	,	,
cord-006229-7yoilsho	1389	3	we	-PRON-	PRP
cord-006229-7yoilsho	1389	4	applied	apply	VBD
cord-006229-7yoilsho	1389	5	the	the	DT
cord-006229-7yoilsho	1389	6	human	human	JJ
cord-006229-7yoilsho	1389	7	M1	M1	NNP
cord-006229-7yoilsho	1389	8	mAChR	mAChR	NNP
cord-006229-7yoilsho	1389	9	which	which	WDT
cord-006229-7yoilsho	1389	10	preferentially	preferentially	RB
cord-006229-7yoilsho	1389	11	activates	activate	VBZ
cord-006229-7yoilsho	1389	12	G	g	NN
cord-006229-7yoilsho	1389	13	proteins	protein	NNS
cord-006229-7yoilsho	1389	14	of	of	IN
cord-006229-7yoilsho	1389	15	the	the	DT
cord-006229-7yoilsho	1389	16	G	g	NN
cord-006229-7yoilsho	1389	17	q/11	q/11	NNS
cord-006229-7yoilsho	1389	18	type	type	NN
cord-006229-7yoilsho	1389	19	but	but	CC
cord-006229-7yoilsho	1389	20	can	can	MD
cord-006229-7yoilsho	1389	21	also	also	RB
cord-006229-7yoilsho	1389	22	promiscuously	promiscuously	RB
cord-006229-7yoilsho	1389	23	stimulate	stimulate	VB
cord-006229-7yoilsho	1389	24	G	G	NNP
cord-006229-7yoilsho	1389	25	s	s	NN
cord-006229-7yoilsho	1389	26	proteins	protein	NNS
cord-006229-7yoilsho	1389	27	.	.	.
cord-006229-7yoilsho	1390	1	G	G	NNP
cord-006229-7yoilsho	1390	2	q/11	q/11	NNS
cord-006229-7yoilsho	1390	3	-and	-and	.
cord-006229-7yoilsho	1391	1	G	g	NN
cord-006229-7yoilsho	1391	2	sdependent	sdependent	NN
cord-006229-7yoilsho	1391	3	signaling	signal	VBG
cord-006229-7yoilsho	1391	4	pathways	pathway	NNS
cord-006229-7yoilsho	1391	5	were	be	VBD
cord-006229-7yoilsho	1391	6	analyzed	analyze	VBN
cord-006229-7yoilsho	1391	7	by	by	IN
cord-006229-7yoilsho	1391	8	application	application	NN
cord-006229-7yoilsho	1391	9	of	of	IN
cord-006229-7yoilsho	1391	10	CHO	CHO	NNP
cord-006229-7yoilsho	1391	11	cells	cell	NNS
cord-006229-7yoilsho	1391	12	stably	stably	RB
cord-006229-7yoilsho	1391	13	transfected	transfecte	VBN
cord-006229-7yoilsho	1391	14	with	with	IN
cord-006229-7yoilsho	1391	15	the	the	DT
cord-006229-7yoilsho	1391	16	human	human	JJ
cord-006229-7yoilsho	1391	17	M1	M1	NNP
cord-006229-7yoilsho	1391	18	mAChR	mAChR	NNP
cord-006229-7yoilsho	1391	19	in	in	IN
cord-006229-7yoilsho	1391	20	IP1	IP1	NNP
cord-006229-7yoilsho	1391	21	and	and	CC
cord-006229-7yoilsho	1391	22	cAMP	camp	NN
cord-006229-7yoilsho	1391	23	accumulation	accumulation	NN
cord-006229-7yoilsho	1391	24	assays	assay	NNS
cord-006229-7yoilsho	1391	25	,	,	,
cord-006229-7yoilsho	1391	26	respectively	respectively	RB
cord-006229-7yoilsho	1391	27	.	.	.
cord-006229-7yoilsho	1392	1	In	in	IN
cord-006229-7yoilsho	1392	2	comparison	comparison	NN
cord-006229-7yoilsho	1392	3	to	to	IN
cord-006229-7yoilsho	1392	4	the	the	DT
cord-006229-7yoilsho	1392	5	orthosteric	orthosteric	NNP
cord-006229-7yoilsho	1392	6	building	building	NN
cord-006229-7yoilsho	1392	7	block	block	NN
cord-006229-7yoilsho	1392	8	iperoxo	iperoxo	NNP
cord-006229-7yoilsho	1392	9	,	,	,
cord-006229-7yoilsho	1392	10	all	all	DT
cord-006229-7yoilsho	1392	11	dualsteric	dualsteric	JJ
cord-006229-7yoilsho	1392	12	compounds	compound	NNS
cord-006229-7yoilsho	1392	13	under	under	IN
cord-006229-7yoilsho	1392	14	investigation	investigation	NN
cord-006229-7yoilsho	1392	15	showed	show	VBD
cord-006229-7yoilsho	1392	16	a	a	DT
cord-006229-7yoilsho	1392	17	decrease	decrease	NN
cord-006229-7yoilsho	1392	18	in	in	IN
cord-006229-7yoilsho	1392	19	potency	potency	NN
cord-006229-7yoilsho	1392	20	for	for	IN
cord-006229-7yoilsho	1392	21	both	both	CC
cord-006229-7yoilsho	1392	22	G	g	NN
cord-006229-7yoilsho	1392	23	q	q	NN
cord-006229-7yoilsho	1392	24	-mediated	-mediated	NNP
cord-006229-7yoilsho	1392	25	and	and	CC
cord-006229-7yoilsho	1392	26	G	G	NNP
cord-006229-7yoilsho	1392	27	s	s	NNP
cord-006229-7yoilsho	1392	28	-mediated	-mediated	JJ
cord-006229-7yoilsho	1392	29	signaling	signaling	NN
cord-006229-7yoilsho	1392	30	.	.	.
cord-006229-7yoilsho	1393	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	1393	2	findings	finding	NNS
cord-006229-7yoilsho	1393	3	show	show	VBP
cord-006229-7yoilsho	1393	4	that	that	IN
cord-006229-7yoilsho	1393	5	the	the	DT
cord-006229-7yoilsho	1393	6	bulkier	bulky	JJR
cord-006229-7yoilsho	1393	7	allosteric	allosteric	JJ
cord-006229-7yoilsho	1393	8	naph	naph	NN
cord-006229-7yoilsho	1393	9	residue	residue	NN
cord-006229-7yoilsho	1393	10	impaired	impair	VBD
cord-006229-7yoilsho	1393	11	both	both	DT
cord-006229-7yoilsho	1393	12	signaling	signal	VBG
cord-006229-7yoilsho	1393	13	pathways	pathway	NNS
cord-006229-7yoilsho	1393	14	to	to	IN
cord-006229-7yoilsho	1393	15	a	a	DT
cord-006229-7yoilsho	1393	16	greater	great	JJR
cord-006229-7yoilsho	1393	17	extent	extent	NN
cord-006229-7yoilsho	1393	18	than	than	IN
cord-006229-7yoilsho	1393	19	the	the	DT
cord-006229-7yoilsho	1393	20	smaller	small	JJR
cord-006229-7yoilsho	1393	21	substituent	substituent	NN
cord-006229-7yoilsho	1393	22	phth	phth	VBN
cord-006229-7yoilsho	1393	23	.	.	.
cord-006229-7yoilsho	1394	1	Particularly	particularly	RB
cord-006229-7yoilsho	1394	2	,	,	,
cord-006229-7yoilsho	1394	3	the	the	DT
cord-006229-7yoilsho	1394	4	compound	compound	NN
cord-006229-7yoilsho	1394	5	iper-6-naph	iper-6-naph	NNP
cord-006229-7yoilsho	1394	6	completely	completely	RB
cord-006229-7yoilsho	1394	7	lost	lose	VBD
cord-006229-7yoilsho	1394	8	intrinsic	intrinsic	JJ
cord-006229-7yoilsho	1394	9	activity	activity	NN
cord-006229-7yoilsho	1394	10	for	for	IN
cord-006229-7yoilsho	1394	11	both	both	CC
cord-006229-7yoilsho	1394	12	G	g	NN
cord-006229-7yoilsho	1394	13	q/11	q/11	NNS
cord-006229-7yoilsho	1394	14	and	and	CC
cord-006229-7yoilsho	1394	15	G	G	NNP
cord-006229-7yoilsho	1394	16	s	s	NNP
cord-006229-7yoilsho	1394	17	activation	activation	NN
cord-006229-7yoilsho	1394	18	at	at	IN
cord-006229-7yoilsho	1394	19	the	the	DT
cord-006229-7yoilsho	1394	20	M1	M1	NNP
cord-006229-7yoilsho	1394	21	mAChR.	machr.	NN
cord-006229-7yoilsho	1395	1	Moreover	moreover	RB
cord-006229-7yoilsho	1395	2	,	,	,
cord-006229-7yoilsho	1395	3	G	G	NNP
cord-006229-7yoilsho	1395	4	s	s	POS
cord-006229-7yoilsho	1395	5	-mediated	-mediated	JJ
cord-006229-7yoilsho	1395	6	pathway	pathway	NN
cord-006229-7yoilsho	1395	7	activation	activation	NN
cord-006229-7yoilsho	1395	8	is	be	VBZ
cord-006229-7yoilsho	1395	9	more	more	RBR
cord-006229-7yoilsho	1395	10	sensitive	sensitive	JJ
cord-006229-7yoilsho	1395	11	to	to	IN
cord-006229-7yoilsho	1395	12	spatial	spatial	JJ
cord-006229-7yoilsho	1395	13	restriction	restriction	NN
cord-006229-7yoilsho	1395	14	in	in	IN
cord-006229-7yoilsho	1395	15	the	the	DT
cord-006229-7yoilsho	1395	16	allosteric	allosteric	JJ
cord-006229-7yoilsho	1395	17	vestibule	vestibule	NN
cord-006229-7yoilsho	1395	18	than	than	IN
cord-006229-7yoilsho	1395	19	G	g	NN
cord-006229-7yoilsho	1395	20	q	q	NN
cord-006229-7yoilsho	1396	1	-signaling	-signale	VBG
cord-006229-7yoilsho	1396	2	.	.	.
cord-006229-7yoilsho	1397	1	Interestingly	interestingly	RB
cord-006229-7yoilsho	1397	2	,	,	,
cord-006229-7yoilsho	1397	3	longer	long	RBR
cord-006229-7yoilsho	1397	4	linker	linker	NN
cord-006229-7yoilsho	1397	5	length	length	NN
cord-006229-7yoilsho	1397	6	led	lead	VBN
cord-006229-7yoilsho	1397	7	to	to	IN
cord-006229-7yoilsho	1397	8	improved	improve	VBN
cord-006229-7yoilsho	1397	9	signaling	signaling	NN
cord-006229-7yoilsho	1397	10	for	for	IN
cord-006229-7yoilsho	1397	11	both	both	DT
cord-006229-7yoilsho	1397	12	pathways	pathway	NNS
cord-006229-7yoilsho	1397	13	(	(	-LRB-
cord-006229-7yoilsho	1397	14	G	g	NN
cord-006229-7yoilsho	1397	15	q	q	NN
cord-006229-7yoilsho	1397	16	and	and	CC
cord-006229-7yoilsho	1397	17	G	G	NNP
cord-006229-7yoilsho	1397	18	s	s	NNPS
cord-006229-7yoilsho	1397	19	)	)	-RRB-
cord-006229-7yoilsho	1397	20	in	in	IN
cord-006229-7yoilsho	1397	21	both	both	DT
cord-006229-7yoilsho	1397	22	hybrid	hybrid	JJ
cord-006229-7yoilsho	1397	23	series	series	NN
cord-006229-7yoilsho	1397	24	.	.	.
cord-006229-7yoilsho	1398	1	Iper-7-phth	Iper-7-phth	NNP
cord-006229-7yoilsho	1398	2	seems	seem	VBZ
cord-006229-7yoilsho	1398	3	to	to	TO
cord-006229-7yoilsho	1398	4	be	be	VB
cord-006229-7yoilsho	1398	5	an	an	DT
cord-006229-7yoilsho	1398	6	exception	exception	NN
cord-006229-7yoilsho	1398	7	as	as	IN
cord-006229-7yoilsho	1398	8	it	-PRON-	PRP
cord-006229-7yoilsho	1398	9	had	have	VBD
cord-006229-7yoilsho	1398	10	a	a	DT
cord-006229-7yoilsho	1398	11	higher	high	JJR
cord-006229-7yoilsho	1398	12	intrinsic	intrinsic	JJ
cord-006229-7yoilsho	1398	13	efficacy	efficacy	NN
cord-006229-7yoilsho	1398	14	for	for	IN
cord-006229-7yoilsho	1398	15	G	G	NNP
cord-006229-7yoilsho	1398	16	s	s	NNP
cord-006229-7yoilsho	1398	17	-dependent	-dependent	NN
cord-006229-7yoilsho	1398	18	signaling	signal	VBG
cord-006229-7yoilsho	1398	19	than	than	IN
cord-006229-7yoilsho	1398	20	the	the	DT
cord-006229-7yoilsho	1398	21	other	other	JJ
cord-006229-7yoilsho	1398	22	phth	phth	JJ
cord-006229-7yoilsho	1398	23	hybrids	hybrid	NNS
cord-006229-7yoilsho	1398	24	with	with	IN
cord-006229-7yoilsho	1398	25	longer	long	JJR
cord-006229-7yoilsho	1398	26	linker	linker	NN
cord-006229-7yoilsho	1398	27	chains	chain	NNS
cord-006229-7yoilsho	1398	28	.	.	.
cord-006229-7yoilsho	1399	1	Strikingly	strikingly	RB
cord-006229-7yoilsho	1399	2	,	,	,
cord-006229-7yoilsho	1399	3	only	only	RB
cord-006229-7yoilsho	1399	4	iper	iper	NN
cord-006229-7yoilsho	1399	5	-	-	HYPH
cord-006229-7yoilsho	1399	6	fri	fri	NNP
cord-006229-7yoilsho	1399	7	-	-	HYPH
cord-006229-7yoilsho	1399	8	phth	phth	NNP
cord-006229-7yoilsho	1399	9	,	,	,
cord-006229-7yoilsho	1399	10	which	which	WDT
cord-006229-7yoilsho	1399	11	corresponds	correspond	VBZ
cord-006229-7yoilsho	1399	12	to	to	IN
cord-006229-7yoilsho	1399	13	iper-8-phth	iper-8-phth	NN
cord-006229-7yoilsho	1399	14	in	in	IN
cord-006229-7yoilsho	1399	15	linker	linker	NN
cord-006229-7yoilsho	1399	16	length	length	NN
cord-006229-7yoilsho	1399	17	,	,	,
cord-006229-7yoilsho	1399	18	but	but	CC
cord-006229-7yoilsho	1399	19	is	be	VBZ
cord-006229-7yoilsho	1399	20	able	able	JJ
cord-006229-7yoilsho	1399	21	to	to	TO
cord-006229-7yoilsho	1399	22	engage	engage	VB
cord-006229-7yoilsho	1399	23	increased	increase	VBN
cord-006229-7yoilsho	1399	24	hydrogen	hydrogen	NN
cord-006229-7yoilsho	1399	25	bonding	bonding	NN
cord-006229-7yoilsho	1399	26	with	with	IN
cord-006229-7yoilsho	1399	27	the	the	DT
cord-006229-7yoilsho	1399	28	receptor	receptor	NN
cord-006229-7yoilsho	1399	29	protein	protein	NN
cord-006229-7yoilsho	1399	30	,	,	,
cord-006229-7yoilsho	1399	31	acted	act	VBD
cord-006229-7yoilsho	1399	32	as	as	IN
cord-006229-7yoilsho	1399	33	a	a	DT
cord-006229-7yoilsho	1399	34	full	full	JJ
cord-006229-7yoilsho	1399	35	agonist	agonist	NN
cord-006229-7yoilsho	1399	36	on	on	IN
cord-006229-7yoilsho	1399	37	M1	M1	NNP
cord-006229-7yoilsho	1399	38	mAChR	mAChR	NNP
cord-006229-7yoilsho	1399	39	for	for	IN
cord-006229-7yoilsho	1399	40	both	both	DT
cord-006229-7yoilsho	1399	41	signaling	signal	VBG
cord-006229-7yoilsho	1399	42	pathways	pathway	NNS
cord-006229-7yoilsho	1399	43	under	under	IN
cord-006229-7yoilsho	1399	44	investigation	investigation	NN
cord-006229-7yoilsho	1399	45	.	.	.
cord-006229-7yoilsho	1400	1	Taken	take	VBN
cord-006229-7yoilsho	1400	2	together	together	RB
cord-006229-7yoilsho	1400	3	,	,	,
cord-006229-7yoilsho	1400	4	these	these	DT
cord-006229-7yoilsho	1400	5	data	datum	NNS
cord-006229-7yoilsho	1400	6	strongly	strongly	RB
cord-006229-7yoilsho	1400	7	suggest	suggest	VBP
cord-006229-7yoilsho	1400	8	that	that	IN
cord-006229-7yoilsho	1400	9	,	,	,
cord-006229-7yoilsho	1400	10	in	in	IN
cord-006229-7yoilsho	1400	11	comparison	comparison	NN
cord-006229-7yoilsho	1400	12	to	to	IN
cord-006229-7yoilsho	1400	13	G	g	NN
cord-006229-7yoilsho	1400	14	q/11	q/11	NNS
cord-006229-7yoilsho	1400	15	-mediated	-mediated	JJ
cord-006229-7yoilsho	1400	16	signaling	signaling	NN
cord-006229-7yoilsho	1400	17	,	,	,
cord-006229-7yoilsho	1400	18	activation	activation	NN
cord-006229-7yoilsho	1400	19	of	of	IN
cord-006229-7yoilsho	1400	20	the	the	DT
cord-006229-7yoilsho	1400	21	G	G	NNP
cord-006229-7yoilsho	1400	22	s	s	NNP
cord-006229-7yoilsho	1400	23	protein	protein	NN
cord-006229-7yoilsho	1400	24	in	in	IN
cord-006229-7yoilsho	1400	25	M1	M1	NNP
cord-006229-7yoilsho	1400	26	mAChR	mAChR	NNP
cord-006229-7yoilsho	1400	27	is	be	VBZ
cord-006229-7yoilsho	1400	28	more	more	RBR
cord-006229-7yoilsho	1400	29	sensitive	sensitive	JJ
cord-006229-7yoilsho	1400	30	to	to	IN
cord-006229-7yoilsho	1400	31	spatial	spatial	JJ
cord-006229-7yoilsho	1400	32	restriction	restriction	NN
cord-006229-7yoilsho	1400	33	in	in	IN
cord-006229-7yoilsho	1400	34	the	the	DT
cord-006229-7yoilsho	1400	35	allosteric	allosteric	JJ
cord-006229-7yoilsho	1400	36	vestibule	vestibule	NN
cord-006229-7yoilsho	1400	37	.	.	.
cord-006229-7yoilsho	1401	1	Thus	thus	RB
cord-006229-7yoilsho	1401	2	,	,	,
cord-006229-7yoilsho	1401	3	it	-PRON-	PRP
cord-006229-7yoilsho	1401	4	appears	appear	VBZ
cord-006229-7yoilsho	1401	5	to	to	TO
cord-006229-7yoilsho	1401	6	be	be	VB
cord-006229-7yoilsho	1401	7	possible	possible	JJ
cord-006229-7yoilsho	1401	8	to	to	TO
cord-006229-7yoilsho	1401	9	control	control	VB
cord-006229-7yoilsho	1401	10	signaling	signaling	NN
cord-006229-7yoilsho	1401	11	of	of	IN
cord-006229-7yoilsho	1401	12	the	the	DT
cord-006229-7yoilsho	1401	13	M1	M1	NNP
cord-006229-7yoilsho	1401	14	mAChR	mAChR	NNP
cord-006229-7yoilsho	1401	15	by	by	IN
cord-006229-7yoilsho	1401	16	allosteric	allosteric	JJ
cord-006229-7yoilsho	1401	17	constraint	constraint	NN
cord-006229-7yoilsho	1401	18	of	of	IN
cord-006229-7yoilsho	1401	19	the	the	DT
cord-006229-7yoilsho	1401	20	receptor	receptor	NN
cord-006229-7yoilsho	1401	21	's	's	POS
cord-006229-7yoilsho	1401	22	conformational	conformational	JJ
cord-006229-7yoilsho	1401	23	flexibility	flexibility	NN
cord-006229-7yoilsho	1401	24	.	.	.
cord-006229-7yoilsho	1402	1	For	for	IN
cord-006229-7yoilsho	1402	2	more	more	JJR
cord-006229-7yoilsho	1402	3	than	than	IN
cord-006229-7yoilsho	1402	4	three	three	CD
cord-006229-7yoilsho	1402	5	decades	decade	NNS
cord-006229-7yoilsho	1402	6	3-(1H	3-(1H	VBN
cord-006229-7yoilsho	1402	7	-	-	HYPH
cord-006229-7yoilsho	1402	8	imidazol-4-yl)propylguanidine	imidazol-4-yl)propylguanidine	NN
cord-006229-7yoilsho	1402	9	(	(	-LRB-
cord-006229-7yoilsho	1402	10	SK&F-91,486	SK&F-91,486	NNP
cord-006229-7yoilsho	1402	11	(	(	-LRB-
cord-006229-7yoilsho	1402	12	1	1	CD
cord-006229-7yoilsho	1402	13	)	)	-RRB-
cord-006229-7yoilsho	1402	14	[	[	-LRB-
cord-006229-7yoilsho	1402	15	1	1	CD
cord-006229-7yoilsho	1402	16	]	]	-RRB-
cord-006229-7yoilsho	1402	17	)	)	-RRB-
cord-006229-7yoilsho	1402	18	is	be	VBZ
cord-006229-7yoilsho	1402	19	known	know	VBN
cord-006229-7yoilsho	1402	20	as	as	IN
cord-006229-7yoilsho	1402	21	the	the	DT
cord-006229-7yoilsho	1402	22	prototypic	prototypic	JJ
cord-006229-7yoilsho	1402	23	pharmacophore	pharmacophore	NN
cord-006229-7yoilsho	1402	24	of	of	IN
cord-006229-7yoilsho	1402	25	highly	highly	RB
cord-006229-7yoilsho	1402	26	potent	potent	JJ
cord-006229-7yoilsho	1403	1	histamine	histamine	NN
cord-006229-7yoilsho	1403	2	H	H	NNP
cord-006229-7yoilsho	1403	3	2	2	CD
cord-006229-7yoilsho	1404	1	-receptor	-receptor	.
cord-006229-7yoilsho	1405	1	(	(	-LRB-
cord-006229-7yoilsho	1405	2	H	h	NN
cord-006229-7yoilsho	1405	3	2	2	CD
cord-006229-7yoilsho	1405	4	R	r	NN
cord-006229-7yoilsho	1405	5	)	)	-RRB-
cord-006229-7yoilsho	1405	6	agonists	agonist	NNS
cord-006229-7yoilsho	1405	7	of	of	IN
cord-006229-7yoilsho	1405	8	the	the	DT
cord-006229-7yoilsho	1405	9	guanidine	guanidine	NNP
cord-006229-7yoilsho	1405	10	class	class	NN
cord-006229-7yoilsho	1405	11	of	of	IN
cord-006229-7yoilsho	1405	12	compounds	compound	NNS
cord-006229-7yoilsho	1405	13	including	include	VBG
cord-006229-7yoilsho	1405	14	,	,	,
cord-006229-7yoilsho	1405	15	e.g.	e.g.	RB
cord-006229-7yoilsho	1405	16	,	,	,
cord-006229-7yoilsho	1405	17	impromidine	impromidine	NN
cord-006229-7yoilsho	1405	18	and	and	CC
cord-006229-7yoilsho	1405	19	arpromidine	arpromidine	NN
cord-006229-7yoilsho	1405	20	.	.	.
cord-006229-7yoilsho	1406	1	[	[	-LRB-
cord-006229-7yoilsho	1406	2	2	2	CD
cord-006229-7yoilsho	1406	3	]	]	-RRB-
cord-006229-7yoilsho	1407	1	In	in	IN
cord-006229-7yoilsho	1407	2	order	order	NN
cord-006229-7yoilsho	1407	3	to	to	TO
cord-006229-7yoilsho	1407	4	get	get	VB
cord-006229-7yoilsho	1407	5	more	more	JJR
cord-006229-7yoilsho	1407	6	insight	insight	NN
cord-006229-7yoilsho	1407	7	into	into	IN
cord-006229-7yoilsho	1407	8	the	the	DT
cord-006229-7yoilsho	1407	9	structure	structure	NN
cord-006229-7yoilsho	1407	10	-	-	HYPH
cord-006229-7yoilsho	1407	11	activity	activity	NN
cord-006229-7yoilsho	1407	12	relationships	relationship	NNS
cord-006229-7yoilsho	1407	13	of	of	IN
cord-006229-7yoilsho	1407	14	alkylated	alkylated	JJ
cord-006229-7yoilsho	1407	15	analogues	analogue	NNS
cord-006229-7yoilsho	1407	16	of	of	IN
cord-006229-7yoilsho	1407	17	SK&F-91,486	SK&F-91,486	NNP
cord-006229-7yoilsho	1407	18	,	,	,
cord-006229-7yoilsho	1407	19	we	-PRON-	PRP
cord-006229-7yoilsho	1407	20	characterized	characterize	VBD
cord-006229-7yoilsho	1407	21	78	78	CD
cord-006229-7yoilsho	1407	22	newly	newly	RB
cord-006229-7yoilsho	1407	23	synthesized	synthesize	VBN
cord-006229-7yoilsho	1407	24	derivatives	derivative	NNS
cord-006229-7yoilsho	1407	25	including	include	VBG
cord-006229-7yoilsho	1407	26	several	several	JJ
cord-006229-7yoilsho	1407	27	bivalent	bivalent	JJ
cord-006229-7yoilsho	1407	28	compounds	compound	NNS
cord-006229-7yoilsho	1407	29	(	(	-LRB-
cord-006229-7yoilsho	1407	30	e.g.	e.g.	RB
cord-006229-7yoilsho	1407	31	,	,	,
cord-006229-7yoilsho	1407	32	2	2	CD
cord-006229-7yoilsho	1407	33	)	)	-RRB-
cord-006229-7yoilsho	1407	34	by	by	IN
cord-006229-7yoilsho	1407	35	using	use	VBG
cord-006229-7yoilsho	1407	36	different	different	JJ
cord-006229-7yoilsho	1407	37	pharmacological	pharmacological	JJ
cord-006229-7yoilsho	1407	38	in	in	IN
cord-006229-7yoilsho	1407	39	-	-	HYPH
cord-006229-7yoilsho	1407	40	vitro	vitro	FW
cord-006229-7yoilsho	1407	41	methods	method	NNS
cord-006229-7yoilsho	1407	42	.	.	.
cord-006229-7yoilsho	1408	1	[	[	-LRB-
cord-006229-7yoilsho	1408	2	3	3	CD
cord-006229-7yoilsho	1408	3	]	]	-RRB-
cord-006229-7yoilsho	1409	1	The	the	DT
cord-006229-7yoilsho	1409	2	potential	potential	JJ
cord-006229-7yoilsho	1409	3	H	h	NN
cord-006229-7yoilsho	1409	4	2	2	CD
cord-006229-7yoilsho	1409	5	R	r	NN
cord-006229-7yoilsho	1409	6	agonists	agonist	NNS
cord-006229-7yoilsho	1409	7	were	be	VBD
cord-006229-7yoilsho	1409	8	subjected	subject	VBN
cord-006229-7yoilsho	1409	9	to	to	IN
cord-006229-7yoilsho	1409	10	a	a	DT
cord-006229-7yoilsho	1409	11	broad	broad	JJ
cord-006229-7yoilsho	1409	12	screening	screening	NN
cord-006229-7yoilsho	1409	13	procedure	procedure	NN
cord-006229-7yoilsho	1409	14	utilizing	utilize	VBG
cord-006229-7yoilsho	1409	15	radioligand	radioligand	JJ
cord-006229-7yoilsho	1409	16	binding	bind	VBG
cord-006229-7yoilsho	1409	17	assays	assay	NNS
cord-006229-7yoilsho	1409	18	with	with	IN
cord-006229-7yoilsho	1409	19	membranes	membrane	NNS
cord-006229-7yoilsho	1409	20	of	of	IN
cord-006229-7yoilsho	1409	21	Sf9	sf9	NN
cord-006229-7yoilsho	1409	22	cells	cell	NNS
cord-006229-7yoilsho	1409	23	[	[	-LRB-
cord-006229-7yoilsho	1409	24	4	4	CD
cord-006229-7yoilsho	1409	25	]	]	-RRB-
cord-006229-7yoilsho	1409	26	(	(	-LRB-
cord-006229-7yoilsho	1409	27	hH	hh	UH
cord-006229-7yoilsho	1409	28	1,2,3,4	1,2,3,4	UH
cord-006229-7yoilsho	1409	29	R	r	NN
cord-006229-7yoilsho	1409	30	)	)	-RRB-
cord-006229-7yoilsho	1409	31	.	.	.
cord-006229-7yoilsho	1410	1	Compounds	compound	NNS
cord-006229-7yoilsho	1410	2	were	be	VBD
cord-006229-7yoilsho	1410	3	also	also	RB
cord-006229-7yoilsho	1410	4	functionally	functionally	RB
cord-006229-7yoilsho	1410	5	characterized	characterize	VBN
cord-006229-7yoilsho	1410	6	in	in	IN
cord-006229-7yoilsho	1410	7	the	the	DT
cord-006229-7yoilsho	1410	8	[	[	-LRB-
cord-006229-7yoilsho	1410	9	35	35	CD
cord-006229-7yoilsho	1410	10	S]GTPgS	S]GTPgS	NNP
cord-006229-7yoilsho	1410	11	assay	assay	NN
cord-006229-7yoilsho	1410	12	(	(	-LRB-
cord-006229-7yoilsho	1410	13	hH	hh	NN
cord-006229-7yoilsho	1410	14	2	2	CD
cord-006229-7yoilsho	1410	15	R	r	NN
cord-006229-7yoilsho	1410	16	,	,	,
cord-006229-7yoilsho	1410	17	Sf9	sf9	NN
cord-006229-7yoilsho	1410	18	cell	cell	NN
cord-006229-7yoilsho	1410	19	membranes	membrane	NNS
cord-006229-7yoilsho	1410	20	)	)	-RRB-
cord-006229-7yoilsho	1410	21	.	.	.
cord-006229-7yoilsho	1411	1	[	[	-LRB-
cord-006229-7yoilsho	1411	2	5	5	CD
cord-006229-7yoilsho	1411	3	]	]	-RRB-
cord-006229-7yoilsho	1411	4	Selectivity	selectivity	NN
cord-006229-7yoilsho	1411	5	vs.	vs.	FW
cord-006229-7yoilsho	1411	6	hH	hh	XX
cord-006229-7yoilsho	1412	1	1,3,4	1,3,4	CD
cord-006229-7yoilsho	1412	2	R	r	NN
cord-006229-7yoilsho	1412	3	was	be	VBD
cord-006229-7yoilsho	1412	4	determined	determine	VBN
cord-006229-7yoilsho	1412	5	for	for	IN
cord-006229-7yoilsho	1412	6	selected	select	VBN
cord-006229-7yoilsho	1412	7	derivatives	derivative	NNS
cord-006229-7yoilsho	1412	8	also	also	RB
cord-006229-7yoilsho	1412	9	using	use	VBG
cord-006229-7yoilsho	1412	10	this	this	DT
cord-006229-7yoilsho	1412	11	technique	technique	NN
cord-006229-7yoilsho	1412	12	.	.	.
cord-006229-7yoilsho	1413	1	Organ	organ	NN
cord-006229-7yoilsho	1413	2	bath	bath	NN
cord-006229-7yoilsho	1413	3	studies	study	NNS
cord-006229-7yoilsho	1413	4	(	(	-LRB-
cord-006229-7yoilsho	1413	5	gpH	gpH	NNP
cord-006229-7yoilsho	1413	6	1	1	CD
cord-006229-7yoilsho	1413	7	R	r	NN
cord-006229-7yoilsho	1413	8	(	(	-LRB-
cord-006229-7yoilsho	1413	9	ileum	ileum	NN
cord-006229-7yoilsho	1413	10	)	)	-RRB-
cord-006229-7yoilsho	1413	11	,	,	,
cord-006229-7yoilsho	1413	12	gpH	gph	JJ
cord-006229-7yoilsho	1413	13	2	2	CD
cord-006229-7yoilsho	1413	14	R	r	NN
cord-006229-7yoilsho	1413	15	(	(	-LRB-
cord-006229-7yoilsho	1413	16	right	right	JJ
cord-006229-7yoilsho	1413	17	atrium	atrium	NN
cord-006229-7yoilsho	1413	18	)	)	-RRB-
cord-006229-7yoilsho	1413	19	)	)	-RRB-
cord-006229-7yoilsho	1413	20	yielded	yield	VBD
cord-006229-7yoilsho	1413	21	functional	functional	JJ
cord-006229-7yoilsho	1413	22	data	datum	NNS
cord-006229-7yoilsho	1413	23	in	in	IN
cord-006229-7yoilsho	1413	24	a	a	DT
cord-006229-7yoilsho	1413	25	more	more	RBR
cord-006229-7yoilsho	1413	26	physiological	physiological	JJ
cord-006229-7yoilsho	1413	27	environment	environment	NN
cord-006229-7yoilsho	1413	28	.	.	.
cord-006229-7yoilsho	1414	1	The	the	DT
cord-006229-7yoilsho	1414	2	major	major	JJ
cord-006229-7yoilsho	1414	3	part	part	NN
cord-006229-7yoilsho	1414	4	of	of	IN
cord-006229-7yoilsho	1414	5	the	the	DT
cord-006229-7yoilsho	1414	6	new	new	JJ
cord-006229-7yoilsho	1414	7	SK&F-91,486	sk&f-91,486	JJ
cord-006229-7yoilsho	1414	8	analogues	analogue	NNS
cord-006229-7yoilsho	1414	9	displayed	display	VBD
cord-006229-7yoilsho	1414	10	partial	partial	JJ
cord-006229-7yoilsho	1414	11	or	or	CC
cord-006229-7yoilsho	1414	12	full	full	JJ
cord-006229-7yoilsho	1414	13	agonism	agonism	NN
cord-006229-7yoilsho	1414	14	via	via	IN
cord-006229-7yoilsho	1414	15	hH	hh	NN
cord-006229-7yoilsho	1414	16	2	2	CD
cord-006229-7yoilsho	1414	17	R	r	NN
cord-006229-7yoilsho	1414	18	and	and	CC
cord-006229-7yoilsho	1414	19	gpH	gph	JJ
cord-006229-7yoilsho	1414	20	2	2	CD
cord-006229-7yoilsho	1414	21	R	r	NN
cord-006229-7yoilsho	1414	22	,	,	,
cord-006229-7yoilsho	1414	23	respectively	respectively	RB
cord-006229-7yoilsho	1414	24	.	.	.
cord-006229-7yoilsho	1415	1	The	the	DT
cord-006229-7yoilsho	1415	2	most	most	RBS
cord-006229-7yoilsho	1415	3	potent	potent	JJ
cord-006229-7yoilsho	1415	4	analogue	analogue	NN
cord-006229-7yoilsho	1415	5	,	,	,
cord-006229-7yoilsho	1415	6	bivalent	bivalent	JJ
cord-006229-7yoilsho	1415	7	thiazole	thiazole	NN
cord-006229-7yoilsho	1415	8	-	-	HYPH
cord-006229-7yoilsho	1415	9	type	type	NN
cord-006229-7yoilsho	1415	10	bisguanidine	bisguanidine	NNP
cord-006229-7yoilsho	1415	11	2	2	CD
cord-006229-7yoilsho	1415	12	,	,	,
cord-006229-7yoilsho	1415	13	was	be	VBD
cord-006229-7yoilsho	1415	14	a	a	DT
cord-006229-7yoilsho	1415	15	partial	partial	JJ
cord-006229-7yoilsho	1415	16	agonist	agonist	NN
cord-006229-7yoilsho	1416	1	(	(	-LRB-
cord-006229-7yoilsho	1416	2	E	e	NN
cord-006229-7yoilsho	1416	3	max	max	NN
cord-006229-7yoilsho	1416	4	=	=	SYM
cord-006229-7yoilsho	1416	5	88	88	CD
cord-006229-7yoilsho	1416	6	%	%	NN
cord-006229-7yoilsho	1416	7	)	)	-RRB-
cord-006229-7yoilsho	1416	8	and	and	CC
cord-006229-7yoilsho	1416	9	250-times	250-times	CD
cord-006229-7yoilsho	1416	10	as	as	RB
cord-006229-7yoilsho	1416	11	potent	potent	JJ
cord-006229-7yoilsho	1416	12	as	as	IN
cord-006229-7yoilsho	1416	13	histamine	histamine	NN
cord-006229-7yoilsho	1416	14	vis	vis	FW
cord-006229-7yoilsho	1416	15	-	-	HYPH
cord-006229-7yoilsho	1416	16	à	à	FW
cord-006229-7yoilsho	1416	17	-	-	HYPH
cord-006229-7yoilsho	1416	18	vis	vis	FW
cord-006229-7yoilsho	1416	19	the	the	DT
cord-006229-7yoilsho	1416	20	gpH	gph	JJ
cord-006229-7yoilsho	1416	21	2	2	CD
cord-006229-7yoilsho	1416	22	R.	R.	NNP
cord-006229-7yoilsho	1416	23	Attempts	Attempts	NNP
cord-006229-7yoilsho	1416	24	to	to	TO
cord-006229-7yoilsho	1416	25	antagonize	antagonize	VB
cord-006229-7yoilsho	1416	26	the	the	DT
cord-006229-7yoilsho	1416	27	positive	positive	JJ
cord-006229-7yoilsho	1416	28	chronotropic	chronotropic	JJ
cord-006229-7yoilsho	1416	29	effect	effect	NN
cord-006229-7yoilsho	1416	30	of	of	IN
cord-006229-7yoilsho	1416	31	(	(	-LRB-
cord-006229-7yoilsho	1416	32	partial	partial	JJ
cord-006229-7yoilsho	1416	33	)	)	-RRB-
cord-006229-7yoilsho	1416	34	agonists	agonist	NNS
cord-006229-7yoilsho	1416	35	by	by	IN
cord-006229-7yoilsho	1416	36	preincubation	preincubation	NN
cord-006229-7yoilsho	1416	37	with	with	IN
cord-006229-7yoilsho	1416	38	cimetidine	cimetidine	NN
cord-006229-7yoilsho	1416	39	,	,	,
cord-006229-7yoilsho	1416	40	or	or	CC
cord-006229-7yoilsho	1416	41	by	by	IN
cord-006229-7yoilsho	1416	42	adding	add	VBG
cord-006229-7yoilsho	1416	43	a	a	DT
cord-006229-7yoilsho	1416	44	cimetidine	cimetidine	NN
cord-006229-7yoilsho	1416	45	bolus	bolus	NN
cord-006229-7yoilsho	1416	46	at	at	IN
cord-006229-7yoilsho	1416	47	the	the	DT
cord-006229-7yoilsho	1416	48	end	end	NN
cord-006229-7yoilsho	1416	49	of	of	IN
cord-006229-7yoilsho	1416	50	the	the	DT
cord-006229-7yoilsho	1416	51	concentration	concentration	NN
cord-006229-7yoilsho	1416	52	-	-	HYPH
cord-006229-7yoilsho	1416	53	response	response	NN
cord-006229-7yoilsho	1416	54	curve	curve	NN
cord-006229-7yoilsho	1416	55	,	,	,
cord-006229-7yoilsho	1416	56	respectively	respectively	RB
cord-006229-7yoilsho	1416	57	,	,	,
cord-006229-7yoilsho	1416	58	were	be	VBD
cord-006229-7yoilsho	1416	59	successful	successful	JJ
cord-006229-7yoilsho	1416	60	and	and	CC
cord-006229-7yoilsho	1416	61	furnished	furnish	VBD
cord-006229-7yoilsho	1416	62	pA	pA	NNP
cord-006229-7yoilsho	1416	63	2	2	CD
cord-006229-7yoilsho	1416	64	values	value	NNS
cord-006229-7yoilsho	1416	65	for	for	IN
cord-006229-7yoilsho	1416	66	the	the	DT
cord-006229-7yoilsho	1416	67	antagonist	antagonist	NN
cord-006229-7yoilsho	1416	68	(	(	-LRB-
cord-006229-7yoilsho	1416	69	5.87	5.87	CD
cord-006229-7yoilsho	1416	70	-6.38	-6.38	NFP
cord-006229-7yoilsho	1416	71	)	)	-RRB-
cord-006229-7yoilsho	1416	72	which	which	WDT
cord-006229-7yoilsho	1416	73	are	be	VBP
cord-006229-7yoilsho	1416	74	in	in	IN
cord-006229-7yoilsho	1416	75	accordance	accordance	NN
cord-006229-7yoilsho	1416	76	with	with	IN
cord-006229-7yoilsho	1416	77	literature	literature	NN
cord-006229-7yoilsho	1416	78	data	datum	NNS
cord-006229-7yoilsho	1416	79	.	.	.
cord-006229-7yoilsho	1417	1	However	however	RB
cord-006229-7yoilsho	1417	2	,	,	,
cord-006229-7yoilsho	1417	3	in	in	IN
cord-006229-7yoilsho	1417	4	the	the	DT
cord-006229-7yoilsho	1417	5	functional	functional	JJ
cord-006229-7yoilsho	1417	6	in	in	IN
cord-006229-7yoilsho	1417	7	-	-	HYPH
cord-006229-7yoilsho	1417	8	vitro	vitro	FW
cord-006229-7yoilsho	1417	9	assay	assay	NN
cord-006229-7yoilsho	1417	10	on	on	IN
cord-006229-7yoilsho	1417	11	gpH	gpH	NNP
cord-006229-7yoilsho	1417	12	2	2	CD
cord-006229-7yoilsho	1417	13	R	r	NN
cord-006229-7yoilsho	1417	14	,	,	,
cord-006229-7yoilsho	1417	15	the	the	DT
cord-006229-7yoilsho	1417	16	positive	positive	JJ
cord-006229-7yoilsho	1417	17	chronotropic	chronotropic	JJ
cord-006229-7yoilsho	1417	18	response	response	NN
cord-006229-7yoilsho	1417	19	evoked	evoke	VBN
cord-006229-7yoilsho	1417	20	by	by	IN
cord-006229-7yoilsho	1417	21	SK&F-91,486	SK&F-91,486	NNP
cord-006229-7yoilsho	1417	22	was	be	VBD
cord-006229-7yoilsho	1417	23	surprisingly	surprisingly	RB
cord-006229-7yoilsho	1417	24	resistant	resistant	JJ
cord-006229-7yoilsho	1417	25	to	to	IN
cord-006229-7yoilsho	1417	26	antagonism	antagonism	NN
cord-006229-7yoilsho	1417	27	by	by	IN
cord-006229-7yoilsho	1417	28	cimetidine	cimetidine	NN
cord-006229-7yoilsho	1417	29	and	and	CC
cord-006229-7yoilsho	1417	30	other	other	JJ
cord-006229-7yoilsho	1417	31	typical	typical	JJ
cord-006229-7yoilsho	1417	32	H	h	NN
cord-006229-7yoilsho	1417	33	2	2	CD
cord-006229-7yoilsho	1417	34	R	r	NN
cord-006229-7yoilsho	1417	35	antagonists	antagonist	NNS
cord-006229-7yoilsho	1417	36	(	(	-LRB-
cord-006229-7yoilsho	1417	37	ranitidine	ranitidine	NN
cord-006229-7yoilsho	1417	38	,	,	,
cord-006229-7yoilsho	1417	39	famotidine	famotidine	NNP
cord-006229-7yoilsho	1417	40	)	)	-RRB-
cord-006229-7yoilsho	1417	41	,	,	,
cord-006229-7yoilsho	1417	42	although	although	IN
cord-006229-7yoilsho	1417	43	the	the	DT
cord-006229-7yoilsho	1417	44	compound	compound	NN
cord-006229-7yoilsho	1417	45	so	so	RB
cord-006229-7yoilsho	1417	46	far	far	RB
cord-006229-7yoilsho	1417	47	has	have	VBZ
cord-006229-7yoilsho	1417	48	been	be	VBN
cord-006229-7yoilsho	1417	49	unanimously	unanimously	RB
cord-006229-7yoilsho	1417	50	classified	classify	VBN
cord-006229-7yoilsho	1417	51	by	by	IN
cord-006229-7yoilsho	1417	52	others	other	NNS
cord-006229-7yoilsho	1417	53	as	as	IN
cord-006229-7yoilsho	1417	54	a	a	DT
cord-006229-7yoilsho	1417	55	weak	weak	JJ
cord-006229-7yoilsho	1417	56	partial	partial	JJ
cord-006229-7yoilsho	1417	57	H	h	NN
cord-006229-7yoilsho	1417	58	2	2	CD
cord-006229-7yoilsho	1417	59	R	r	NN
cord-006229-7yoilsho	1417	60	agonist	agonist	NN
cord-006229-7yoilsho	1417	61	.	.	.
cord-006229-7yoilsho	1418	1	This	this	DT
cord-006229-7yoilsho	1418	2	behaviour	behaviour	NN
cord-006229-7yoilsho	1418	3	is	be	VBZ
cord-006229-7yoilsho	1418	4	unique	unique	JJ
cord-006229-7yoilsho	1418	5	within	within	IN
cord-006229-7yoilsho	1418	6	the	the	DT
cord-006229-7yoilsho	1418	7	large	large	JJ
cord-006229-7yoilsho	1418	8	series	series	NN
cord-006229-7yoilsho	1418	9	of	of	IN
cord-006229-7yoilsho	1418	10	SK&F-91,486	SK&F-91,486	NNP
cord-006229-7yoilsho	1418	11	analogues	analogue	NNS
cord-006229-7yoilsho	1418	12	studied	study	VBN
cord-006229-7yoilsho	1418	13	so	so	RB
cord-006229-7yoilsho	1418	14	far	far	RB
cord-006229-7yoilsho	1418	15	under	under	IN
cord-006229-7yoilsho	1418	16	similar	similar	JJ
cord-006229-7yoilsho	1418	17	conditions	condition	NNS
cord-006229-7yoilsho	1418	18	.	.	.
cord-006229-7yoilsho	1419	1	Probably	probably	RB
cord-006229-7yoilsho	1419	2	the	the	DT
cord-006229-7yoilsho	1419	3	positive	positive	JJ
cord-006229-7yoilsho	1419	4	chronotropic	chronotropic	JJ
cord-006229-7yoilsho	1419	5	effect	effect	NN
cord-006229-7yoilsho	1419	6	of	of	IN
cord-006229-7yoilsho	1419	7	the	the	DT
cord-006229-7yoilsho	1419	8	lead	lead	JJ
cord-006229-7yoilsho	1419	9	compound	compound	NN
cord-006229-7yoilsho	1419	10	is	be	VBZ
cord-006229-7yoilsho	1419	11	-at	-at	:
cord-006229-7yoilsho	1419	12	least	least	JJS
cord-006229-7yoilsho	1419	13	in	in	IN
cord-006229-7yoilsho	1419	14	part	part	NN
cord-006229-7yoilsho	1419	15	-the	-the	DT
cord-006229-7yoilsho	1419	16	result	result	NN
cord-006229-7yoilsho	1419	17	of	of	IN
cord-006229-7yoilsho	1419	18	a	a	DT
cord-006229-7yoilsho	1419	19	second	second	JJ
cord-006229-7yoilsho	1419	20	molecular	molecular	JJ
cord-006229-7yoilsho	1419	21	interaction	interaction	NN
cord-006229-7yoilsho	1419	22	which	which	WDT
cord-006229-7yoilsho	1419	23	has	have	VBZ
cord-006229-7yoilsho	1419	24	been	be	VBN
cord-006229-7yoilsho	1419	25	overlooked	overlook	VBN
cord-006229-7yoilsho	1419	26	so	so	RB
cord-006229-7yoilsho	1419	27	far	far	RB
cord-006229-7yoilsho	1419	28	.	.	.
cord-006229-7yoilsho	1420	1	[	[	-LRB-
cord-006229-7yoilsho	1420	2	1	1	CD
cord-006229-7yoilsho	1420	3	]	]	-RRB-
cord-006229-7yoilsho	1420	4	Parsons	Parsons	NNP
cord-006229-7yoilsho	1420	5	,	,	,
cord-006229-7yoilsho	1420	6	M.E.	M.E.	NNP
cord-006229-7yoilsho	1420	7	et	et	NNP
cord-006229-7yoilsho	1420	8	al	al	NNP
cord-006229-7yoilsho	1420	9	.	.	NNP
cord-006229-7yoilsho	1420	10	;	;	:
cord-006229-7yoilsho	1420	11	Agents	Agents	NNPS
cord-006229-7yoilsho	1420	12	Actions	Actions	NNPS
cord-006229-7yoilsho	1420	13	1975	1975	CD
cord-006229-7yoilsho	1420	14	,	,	,
cord-006229-7yoilsho	1420	15	5	5	CD
cord-006229-7yoilsho	1420	16	,	,	,
cord-006229-7yoilsho	1420	17	464	464	CD
cord-006229-7yoilsho	1420	18	.	.	.
cord-006229-7yoilsho	1421	1	[	[	-LRB-
cord-006229-7yoilsho	1421	2	2	2	LS
cord-006229-7yoilsho	1421	3	]	]	-RRB-
cord-006229-7yoilsho	1421	4	Buschauer	Buschauer	NNP
cord-006229-7yoilsho	1421	5	,	,	,
cord-006229-7yoilsho	1421	6	A.	a.	NN
cord-006229-7yoilsho	1421	7	;	;	:
cord-006229-7yoilsho	1421	8	J.	J.	NNP
cord-006229-7yoilsho	1421	9	Med	Med	NNP
cord-006229-7yoilsho	1421	10	.	.	.
cord-006229-7yoilsho	1421	11	Chem	Chem	NNP
cord-006229-7yoilsho	1421	12	.	.	.
cord-006229-7yoilsho	1422	1	1989	1989	CD
cord-006229-7yoilsho	1422	2	,	,	,
cord-006229-7yoilsho	1422	3	32	32	CD
cord-006229-7yoilsho	1422	4	,	,	,
cord-006229-7yoilsho	1422	5	1963	1963	CD
cord-006229-7yoilsho	1422	6	-1970	-1970	NNS
cord-006229-7yoilsho	1422	7	[	[	-LRB-
cord-006229-7yoilsho	1422	8	3	3	CD
cord-006229-7yoilsho	1422	9	]	]	-RRB-
cord-006229-7yoilsho	1422	10	Pockes	Pockes	NNP
cord-006229-7yoilsho	1422	11	,	,	,
cord-006229-7yoilsho	1422	12	S.	S.	NNP
cord-006229-7yoilsho	1422	13	;	;	:
cord-006229-7yoilsho	1422	14	Dissertation	Dissertation	NNP
cord-006229-7yoilsho	1422	15	,	,	,
cord-006229-7yoilsho	1422	16	Univ	Univ	NNP
cord-006229-7yoilsho	1422	17	.	.	.
cord-006229-7yoilsho	1423	1	Regensburg	Regensburg	NNP
cord-006229-7yoilsho	1423	2	2015	2015	CD
cord-006229-7yoilsho	1423	3	.	.	.
cord-006229-7yoilsho	1424	1	[	[	-LRB-
cord-006229-7yoilsho	1424	2	4	4	CD
cord-006229-7yoilsho	1424	3	]	]	-RRB-
cord-006229-7yoilsho	1424	4	Seifert	Seifert	NNP
cord-006229-7yoilsho	1424	5	,	,	,
cord-006229-7yoilsho	1424	6	R.	R.	NNP
cord-006229-7yoilsho	1424	7	;	;	:
cord-006229-7yoilsho	1424	8	J.	J.	NNP
cord-006229-7yoilsho	1424	9	Pharmacol	Pharmacol	NNP
cord-006229-7yoilsho	1424	10	.	.	.
cord-006229-7yoilsho	1425	1	Exp	Exp	NNP
cord-006229-7yoilsho	1425	2	.	.	.
cord-006229-7yoilsho	1426	1	Ther	ther	UH
cord-006229-7yoilsho	1426	2	.	.	.
cord-006229-7yoilsho	1427	1	2003	2003	CD
cord-006229-7yoilsho	1427	2	,	,	,
cord-006229-7yoilsho	1427	3	305	305	CD
cord-006229-7yoilsho	1427	4	(	(	-LRB-
cord-006229-7yoilsho	1427	5	3	3	CD
cord-006229-7yoilsho	1427	6	)	)	-RRB-
cord-006229-7yoilsho	1427	7	,	,	.
cord-006229-7yoilsho	1428	1	1104	1104	CD
cord-006229-7yoilsho	1428	2	-	-	SYM
cord-006229-7yoilsho	1428	3	1115	1115	CD
cord-006229-7yoilsho	1428	4	.	.	.
cord-006229-7yoilsho	1429	1	The	the	DT
cord-006229-7yoilsho	1429	2	nociceptin	nociceptin	NNP
cord-006229-7yoilsho	1429	3	/	/	SYM
cord-006229-7yoilsho	1429	4	orphanin	orphanin	NN
cord-006229-7yoilsho	1429	5	FQ	FQ	NNP
cord-006229-7yoilsho	1430	1	(	(	-LRB-
cord-006229-7yoilsho	1430	2	N	N	NNP
cord-006229-7yoilsho	1430	3	/	/	SYM
cord-006229-7yoilsho	1430	4	OFQ	OFQ	NNP
cord-006229-7yoilsho	1430	5	)	)	-RRB-
cord-006229-7yoilsho	1430	6	peptide	peptide	NN
cord-006229-7yoilsho	1430	7	(	(	-LRB-
cord-006229-7yoilsho	1430	8	NOP	NOP	NNP
cord-006229-7yoilsho	1430	9	)	)	-RRB-
cord-006229-7yoilsho	1430	10	receptor	receptor	NN
cord-006229-7yoilsho	1430	11	is	be	VBZ
cord-006229-7yoilsho	1430	12	the	the	DT
cord-006229-7yoilsho	1430	13	fourth	fourth	JJ
cord-006229-7yoilsho	1430	14	most	most	RBS
cord-006229-7yoilsho	1430	15	recently	recently	RB
cord-006229-7yoilsho	1430	16	discovered	discover	VBN
cord-006229-7yoilsho	1430	17	and	and	CC
cord-006229-7yoilsho	1430	18	least	least	RBS
cord-006229-7yoilsho	1430	19	characterized	characterize	VBN
cord-006229-7yoilsho	1430	20	member	member	NN
cord-006229-7yoilsho	1430	21	of	of	IN
cord-006229-7yoilsho	1430	22	the	the	DT
cord-006229-7yoilsho	1430	23	opioid	opioid	JJ
cord-006229-7yoilsho	1430	24	receptor	receptor	NN
cord-006229-7yoilsho	1430	25	family	family	NN
cord-006229-7yoilsho	1430	26	(	(	-LRB-
cord-006229-7yoilsho	1430	27	MOR	MOR	NNP
cord-006229-7yoilsho	1430	28	,	,	,
cord-006229-7yoilsho	1430	29	KOR	KOR	NNP
cord-006229-7yoilsho	1430	30	and	and	CC
cord-006229-7yoilsho	1430	31	DOR	DOR	NNP
cord-006229-7yoilsho	1430	32	)	)	-RRB-
cord-006229-7yoilsho	1430	33	.	.	.
cord-006229-7yoilsho	1431	1	NOP	NOP	NNP
cord-006229-7yoilsho	1431	2	receptor	receptor	NN
cord-006229-7yoilsho	1431	3	is	be	VBZ
cord-006229-7yoilsho	1431	4	widely	widely	RB
cord-006229-7yoilsho	1431	5	distributed	distribute	VBN
cord-006229-7yoilsho	1431	6	and	and	CC
cord-006229-7yoilsho	1431	7	modulates	modulate	VBZ
cord-006229-7yoilsho	1431	8	several	several	JJ
cord-006229-7yoilsho	1431	9	physiological	physiological	JJ
cord-006229-7yoilsho	1431	10	processes	process	NNS
cord-006229-7yoilsho	1431	11	by	by	IN
cord-006229-7yoilsho	1431	12	its	-PRON-	PRP$
cord-006229-7yoilsho	1431	13	endogenous	endogenous	JJ
cord-006229-7yoilsho	1431	14	ligand	ligand	NN
cord-006229-7yoilsho	1431	15	nociceptin	nociceptin	NN
cord-006229-7yoilsho	1431	16	.	.	.
cord-006229-7yoilsho	1432	1	The	the	DT
cord-006229-7yoilsho	1432	2	NOP	NOP	NNP
cord-006229-7yoilsho	1432	3	receptor	receptor	NN
cord-006229-7yoilsho	1432	4	is	be	VBZ
cord-006229-7yoilsho	1432	5	a	a	DT
cord-006229-7yoilsho	1432	6	potential	potential	JJ
cord-006229-7yoilsho	1432	7	target	target	NN
cord-006229-7yoilsho	1432	8	for	for	IN
cord-006229-7yoilsho	1432	9	the	the	DT
cord-006229-7yoilsho	1432	10	development	development	NN
cord-006229-7yoilsho	1432	11	of	of	IN
cord-006229-7yoilsho	1432	12	ligands	ligand	NNS
cord-006229-7yoilsho	1432	13	with	with	IN
cord-006229-7yoilsho	1432	14	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	1432	15	use	use	NN
cord-006229-7yoilsho	1432	16	in	in	IN
cord-006229-7yoilsho	1432	17	several	several	JJ
cord-006229-7yoilsho	1432	18	pathophysiological	pathophysiological	JJ
cord-006229-7yoilsho	1432	19	states	state	NNS
cord-006229-7yoilsho	1432	20	such	such	JJ
cord-006229-7yoilsho	1432	21	as	as	IN
cord-006229-7yoilsho	1432	22	chronic	chronic	JJ
cord-006229-7yoilsho	1432	23	and	and	CC
cord-006229-7yoilsho	1432	24	neuropathic	neuropathic	JJ
cord-006229-7yoilsho	1432	25	pain	pain	NN
cord-006229-7yoilsho	1432	26	.	.	.
cord-006229-7yoilsho	1433	1	Consequently	consequently	RB
cord-006229-7yoilsho	1433	2	,	,	,
cord-006229-7yoilsho	1433	3	there	there	EX
cord-006229-7yoilsho	1433	4	is	be	VBZ
cord-006229-7yoilsho	1433	5	increasing	increase	VBG
cord-006229-7yoilsho	1433	6	interest	interest	NN
cord-006229-7yoilsho	1433	7	in	in	IN
cord-006229-7yoilsho	1433	8	understanding	understand	VBG
cord-006229-7yoilsho	1433	9	the	the	DT
cord-006229-7yoilsho	1433	10	molecular	molecular	JJ
cord-006229-7yoilsho	1433	11	regulation	regulation	NN
cord-006229-7yoilsho	1433	12	of	of	IN
cord-006229-7yoilsho	1433	13	NOP	NOP	NNP
cord-006229-7yoilsho	1433	14	receptor	receptor	NN
cord-006229-7yoilsho	1433	15	.	.	.
cord-006229-7yoilsho	1434	1	Recently	recently	RB
cord-006229-7yoilsho	1434	2	,	,	,
cord-006229-7yoilsho	1434	3	we	-PRON-	PRP
cord-006229-7yoilsho	1434	4	generated	generate	VBD
cord-006229-7yoilsho	1434	5	two	two	CD
cord-006229-7yoilsho	1434	6	phosphosite	phosphosite	JJ
cord-006229-7yoilsho	1434	7	-	-	HYPH
cord-006229-7yoilsho	1434	8	specific	specific	JJ
cord-006229-7yoilsho	1434	9	antibodies	antibody	NNS
cord-006229-7yoilsho	1434	10	directed	direct	VBN
cord-006229-7yoilsho	1434	11	against	against	IN
cord-006229-7yoilsho	1434	12	the	the	DT
cord-006229-7yoilsho	1434	13	carboxyl	carboxyl	NN
cord-006229-7yoilsho	1434	14	-	-	HYPH
cord-006229-7yoilsho	1434	15	terminal	terminal	NN
cord-006229-7yoilsho	1434	16	residues	residue	NNS
cord-006229-7yoilsho	1434	17	serine	serine	NN
cord-006229-7yoilsho	1434	18	351	351	CD
cord-006229-7yoilsho	1434	19	(	(	-LRB-
cord-006229-7yoilsho	1434	20	S351	s351	NN
cord-006229-7yoilsho	1434	21	)	)	-RRB-
cord-006229-7yoilsho	1434	22	and	and	CC
cord-006229-7yoilsho	1434	23	threonine	threonine	NN
cord-006229-7yoilsho	1434	24	362	362	CD
cord-006229-7yoilsho	1434	25	/serine	/serine	SYM
cord-006229-7yoilsho	1434	26	363	363	CD
cord-006229-7yoilsho	1434	27	(	(	-LRB-
cord-006229-7yoilsho	1434	28	T362	T362	NNP
cord-006229-7yoilsho	1434	29	/	/	SYM
cord-006229-7yoilsho	1434	30	S363	S363	NNPS
cord-006229-7yoilsho	1434	31	)	)	-RRB-
cord-006229-7yoilsho	1434	32	,	,	,
cord-006229-7yoilsho	1434	33	which	which	WDT
cord-006229-7yoilsho	1434	34	enabled	enable	VBD
cord-006229-7yoilsho	1434	35	us	-PRON-	PRP
cord-006229-7yoilsho	1434	36	to	to	TO
cord-006229-7yoilsho	1434	37	selectively	selectively	RB
cord-006229-7yoilsho	1434	38	detect	detect	VB
cord-006229-7yoilsho	1434	39	either	either	CC
cord-006229-7yoilsho	1434	40	the	the	DT
cord-006229-7yoilsho	1434	41	S351-or	s351-or	NN
cord-006229-7yoilsho	1434	42	the	the	DT
cord-006229-7yoilsho	1434	43	T362	T362	NNP
cord-006229-7yoilsho	1434	44	/	/	SYM
cord-006229-7yoilsho	1434	45	S363-phosphorylated	s363-phosphorylate	VBN
cord-006229-7yoilsho	1434	46	forms	form	NNS
cord-006229-7yoilsho	1434	47	of	of	IN
cord-006229-7yoilsho	1434	48	the	the	DT
cord-006229-7yoilsho	1434	49	receptor	receptor	NN
cord-006229-7yoilsho	1434	50	.	.	.
cord-006229-7yoilsho	1435	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	1435	2	results	result	NNS
cord-006229-7yoilsho	1435	3	show	show	VBP
cord-006229-7yoilsho	1435	4	that	that	IN
cord-006229-7yoilsho	1435	5	nociceptin	nociceptin	NNP
cord-006229-7yoilsho	1435	6	,	,	,
cord-006229-7yoilsho	1435	7	MCOPPB	MCOPPB	NNP
cord-006229-7yoilsho	1435	8	,	,	,
cord-006229-7yoilsho	1435	9	SCH221510	SCH221510	NNP
cord-006229-7yoilsho	1435	10	and	and	CC
cord-006229-7yoilsho	1435	11	Ro64	Ro64	NNP
cord-006229-7yoilsho	1435	12	-	-	HYPH
cord-006229-7yoilsho	1435	13	6198	6198	CD
cord-006229-7yoilsho	1435	14	induce	induce	VBP
cord-006229-7yoilsho	1435	15	a	a	DT
cord-006229-7yoilsho	1435	16	stably	stably	RB
cord-006229-7yoilsho	1435	17	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	1435	18	at	at	IN
cord-006229-7yoilsho	1435	19	S351	s351	CD
cord-006229-7yoilsho	1435	20	and	and	CC
cord-006229-7yoilsho	1435	21	T362	T362	NNP
cord-006229-7yoilsho	1435	22	/	/	SYM
cord-006229-7yoilsho	1435	23	S363	S363	NNS
cord-006229-7yoilsho	1435	24	followed	follow	VBN
cord-006229-7yoilsho	1435	25	by	by	IN
cord-006229-7yoilsho	1435	26	a	a	DT
cord-006229-7yoilsho	1435	27	profound	profound	JJ
cord-006229-7yoilsho	1435	28	internalization	internalization	NN
cord-006229-7yoilsho	1435	29	of	of	IN
cord-006229-7yoilsho	1435	30	the	the	DT
cord-006229-7yoilsho	1435	31	receptor	receptor	NN
cord-006229-7yoilsho	1435	32	.	.	.
cord-006229-7yoilsho	1436	1	The	the	DT
cord-006229-7yoilsho	1436	2	nociceptin	nociceptin	NN
cord-006229-7yoilsho	1436	3	-	-	HYPH
cord-006229-7yoilsho	1436	4	induced	induce	VBN
cord-006229-7yoilsho	1436	5	S351	S351	NNP
cord-006229-7yoilsho	1436	6	and	and	CC
cord-006229-7yoilsho	1436	7	T362	T362	NNP
cord-006229-7yoilsho	1436	8	/	/	SYM
cord-006229-7yoilsho	1436	9	S363	S363	NNS
cord-006229-7yoilsho	1436	10	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	1436	11	can	can	MD
cord-006229-7yoilsho	1436	12	be	be	VB
cord-006229-7yoilsho	1436	13	blocked	block	VBN
cord-006229-7yoilsho	1436	14	by	by	IN
cord-006229-7yoilsho	1436	15	selective	selective	JJ
cord-006229-7yoilsho	1436	16	NOP	NOP	NNP
cord-006229-7yoilsho	1436	17	receptor	receptor	NN
cord-006229-7yoilsho	1436	18	antagonists	antagonist	NNS
cord-006229-7yoilsho	1436	19	such	such	JJ
cord-006229-7yoilsho	1436	20	as	as	IN
cord-006229-7yoilsho	1436	21	J113397	J113397	NNP
cord-006229-7yoilsho	1436	22	or	or	CC
cord-006229-7yoilsho	1436	23	SB612,111	SB612,111	NNP
cord-006229-7yoilsho	1436	24	.	.	.
cord-006229-7yoilsho	1437	1	NNC63	NNC63	NNP
cord-006229-7yoilsho	1437	2	-	-	HYPH
cord-006229-7yoilsho	1437	3	0532	0532	CD
cord-006229-7yoilsho	1438	1	,	,	,
cord-006229-7yoilsho	1438	2	buprenorphine	buprenorphine	NN
cord-006229-7yoilsho	1438	3	and	and	CC
cord-006229-7yoilsho	1438	4	norbuprenophine	norbuprenophine	NN
cord-006229-7yoilsho	1438	5	failed	fail	VBD
cord-006229-7yoilsho	1438	6	to	to	TO
cord-006229-7yoilsho	1438	7	induce	induce	VB
cord-006229-7yoilsho	1438	8	a	a	DT
cord-006229-7yoilsho	1438	9	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	1438	10	at	at	IN
cord-006229-7yoilsho	1438	11	these	these	DT
cord-006229-7yoilsho	1438	12	sites	site	NNS
cord-006229-7yoilsho	1438	13	.	.	.
cord-006229-7yoilsho	1439	1	In	in	IN
cord-006229-7yoilsho	1439	2	the	the	DT
cord-006229-7yoilsho	1439	3	presence	presence	NN
cord-006229-7yoilsho	1439	4	of	of	IN
cord-006229-7yoilsho	1439	5	nociceptin	nociceptin	NNP
cord-006229-7yoilsho	1439	6	,	,	,
cord-006229-7yoilsho	1439	7	S351	S351	NNP
cord-006229-7yoilsho	1439	8	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	1439	9	occurred	occur	VBD
cord-006229-7yoilsho	1439	10	at	at	IN
cord-006229-7yoilsho	1439	11	a	a	DT
cord-006229-7yoilsho	1439	12	faster	fast	JJR
cord-006229-7yoilsho	1439	13	rate	rate	NN
cord-006229-7yoilsho	1439	14	than	than	IN
cord-006229-7yoilsho	1439	15	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	1439	16	at	at	IN
cord-006229-7yoilsho	1439	17	T362	T362	NNP
cord-006229-7yoilsho	1439	18	/	/	SYM
cord-006229-7yoilsho	1439	19	S363	S363	NNS
cord-006229-7yoilsho	1439	20	indicating	indicate	VBG
cord-006229-7yoilsho	1439	21	that	that	IN
cord-006229-7yoilsho	1439	22	S351	S351	NNP
cord-006229-7yoilsho	1439	23	is	be	VBZ
cord-006229-7yoilsho	1439	24	the	the	DT
cord-006229-7yoilsho	1439	25	primary	primary	JJ
cord-006229-7yoilsho	1439	26	site	site	NN
cord-006229-7yoilsho	1439	27	of	of	IN
cord-006229-7yoilsho	1439	28	agonistdependent	agonistdependent	NN
cord-006229-7yoilsho	1439	29	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	1439	30	.	.	.
cord-006229-7yoilsho	1440	1	Activation	activation	NN
cord-006229-7yoilsho	1440	2	of	of	IN
cord-006229-7yoilsho	1440	3	PKC	PKC	NNP
cord-006229-7yoilsho	1440	4	by	by	IN
cord-006229-7yoilsho	1440	5	phorbol	phorbol	NNP
cord-006229-7yoilsho	1440	6	12-myristate	12-myristate	CD
cord-006229-7yoilsho	1440	7	13-acetate	13-acetate	CD
cord-006229-7yoilsho	1440	8	facilitated	facilitate	VBN
cord-006229-7yoilsho	1440	9	receptor	receptor	NN
cord-006229-7yoilsho	1440	10	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	1440	11	only	only	RB
cord-006229-7yoilsho	1440	12	at	at	IN
cord-006229-7yoilsho	1440	13	S351	s351	CD
cord-006229-7yoilsho	1440	14	but	but	CC
cord-006229-7yoilsho	1440	15	not	not	RB
cord-006229-7yoilsho	1440	16	at	at	IN
cord-006229-7yoilsho	1440	17	T362	T362	NNP
cord-006229-7yoilsho	1440	18	/	/	SYM
cord-006229-7yoilsho	1440	19	S363	S363	NNPS
cord-006229-7yoilsho	1440	20	,	,	,
cord-006229-7yoilsho	1440	21	indicating	indicate	VBG
cord-006229-7yoilsho	1440	22	that	that	IN
cord-006229-7yoilsho	1440	23	S351	s351	PRP
cord-006229-7yoilsho	1440	24	can	can	MD
cord-006229-7yoilsho	1440	25	also	also	RB
cord-006229-7yoilsho	1440	26	undergo	undergo	VB
cord-006229-7yoilsho	1440	27	heterologous	heterologous	JJ
cord-006229-7yoilsho	1440	28	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	1440	29	.	.	.
cord-006229-7yoilsho	1441	1	Using	use	VBG
cord-006229-7yoilsho	1441	2	NOP	NOP	NNP
cord-006229-7yoilsho	1441	3	-	-	HYPH
cord-006229-7yoilsho	1441	4	GFP	GFP	NNP
cord-006229-7yoilsho	1441	5	knock	knock	VBP
cord-006229-7yoilsho	1441	6	in	in	IN
cord-006229-7yoilsho	1441	7	mice	mouse	NNS
cord-006229-7yoilsho	1441	8	,	,	,
cord-006229-7yoilsho	1441	9	we	-PRON-	PRP
cord-006229-7yoilsho	1441	10	detected	detect	VBD
cord-006229-7yoilsho	1441	11	NOP	NOP	NNP
cord-006229-7yoilsho	1441	12	receptors	receptor	NNS
cord-006229-7yoilsho	1441	13	in	in	IN
cord-006229-7yoilsho	1441	14	brain	brain	NN
cord-006229-7yoilsho	1441	15	,	,	,
cord-006229-7yoilsho	1441	16	spinal	spinal	JJ
cord-006229-7yoilsho	1441	17	cord	cord	NN
cord-006229-7yoilsho	1441	18	and	and	CC
cord-006229-7yoilsho	1441	19	dorsal	dorsal	JJ
cord-006229-7yoilsho	1441	20	root	root	NN
cord-006229-7yoilsho	1441	21	ganglia	ganglion	NNS
cord-006229-7yoilsho	1441	22	(	(	-LRB-
cord-006229-7yoilsho	1441	23	DRG	DRG	NNP
cord-006229-7yoilsho	1441	24	)	)	-RRB-
cord-006229-7yoilsho	1441	25	.	.	.
cord-006229-7yoilsho	1442	1	We	-PRON-	PRP
cord-006229-7yoilsho	1442	2	were	be	VBD
cord-006229-7yoilsho	1442	3	also	also	RB
cord-006229-7yoilsho	1442	4	able	able	JJ
cord-006229-7yoilsho	1442	5	to	to	TO
cord-006229-7yoilsho	1442	6	demonstrate	demonstrate	VB
cord-006229-7yoilsho	1442	7	a	a	DT
cord-006229-7yoilsho	1442	8	dose	dose	NN
cord-006229-7yoilsho	1442	9	-	-	HYPH
cord-006229-7yoilsho	1442	10	dependent	dependent	JJ
cord-006229-7yoilsho	1442	11	NOP	NOP	NNP
cord-006229-7yoilsho	1442	12	receptor	receptor	NN
cord-006229-7yoilsho	1442	13	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	1442	14	at	at	IN
cord-006229-7yoilsho	1442	15	T362	T362	NNP
cord-006229-7yoilsho	1442	16	/	/	SYM
cord-006229-7yoilsho	1442	17	S363	S363	NNPS
cord-006229-7yoilsho	1442	18	in	in	IN
cord-006229-7yoilsho	1442	19	mouse	mouse	NN
cord-006229-7yoilsho	1442	20	brain	brain	NN
cord-006229-7yoilsho	1442	21	in	in	IN
cord-006229-7yoilsho	1442	22	vivo	vivo	NN
cord-006229-7yoilsho	1442	23	using	use	VBG
cord-006229-7yoilsho	1442	24	Western	western	JJ
cord-006229-7yoilsho	1442	25	blot	blot	NN
cord-006229-7yoilsho	1442	26	and	and	CC
cord-006229-7yoilsho	1442	27	mass	mass	NN
cord-006229-7yoilsho	1442	28	spectrometry	spectrometry	NN
cord-006229-7yoilsho	1442	29	.	.	.
cord-006229-7yoilsho	1443	1	In	in	IN
cord-006229-7yoilsho	1443	2	contrast	contrast	NN
cord-006229-7yoilsho	1443	3	,	,	,
cord-006229-7yoilsho	1443	4	MCOPPB	MCOPPB	NNP
cord-006229-7yoilsho	1443	5	and	and	CC
cord-006229-7yoilsho	1443	6	SCH221510	SCH221510	NNP
cord-006229-7yoilsho	1443	7	failed	fail	VBD
cord-006229-7yoilsho	1443	8	to	to	TO
cord-006229-7yoilsho	1443	9	induce	induce	VB
cord-006229-7yoilsho	1443	10	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	1443	11	in	in	IN
cord-006229-7yoilsho	1443	12	vivo	vivo	NN
cord-006229-7yoilsho	1443	13	.	.	.
cord-006229-7yoilsho	1444	1	Together	together	RB
cord-006229-7yoilsho	1444	2	,	,	,
cord-006229-7yoilsho	1444	3	these	these	DT
cord-006229-7yoilsho	1444	4	data	datum	NNS
cord-006229-7yoilsho	1444	5	provide	provide	VBP
cord-006229-7yoilsho	1444	6	new	new	JJ
cord-006229-7yoilsho	1444	7	insights	insight	NNS
cord-006229-7yoilsho	1444	8	into	into	IN
cord-006229-7yoilsho	1444	9	the	the	DT
cord-006229-7yoilsho	1444	10	molecular	molecular	JJ
cord-006229-7yoilsho	1444	11	regulation	regulation	NN
cord-006229-7yoilsho	1444	12	of	of	IN
cord-006229-7yoilsho	1444	13	the	the	DT
cord-006229-7yoilsho	1444	14	NOP	NOP	NNP
cord-006229-7yoilsho	1444	15	receptor	receptor	NN
cord-006229-7yoilsho	1444	16	in	in	IN
cord-006229-7yoilsho	1444	17	vitro	vitro	FW
cord-006229-7yoilsho	1444	18	and	and	CC
cord-006229-7yoilsho	1444	19	in	in	IN
cord-006229-7yoilsho	1444	20	vivo	vivo	NNP
cord-006229-7yoilsho	1444	21	.	.	.
cord-006229-7yoilsho	1445	1	Several	several	JJ
cord-006229-7yoilsho	1445	2	findings	finding	NNS
cord-006229-7yoilsho	1445	3	indicate	indicate	VBP
cord-006229-7yoilsho	1445	4	that	that	IN
cord-006229-7yoilsho	1445	5	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	1445	6	diseases	disease	NNS
cord-006229-7yoilsho	1445	7	are	be	VBP
cord-006229-7yoilsho	1445	8	initiated	initiate	VBN
cord-006229-7yoilsho	1445	9	or	or	CC
cord-006229-7yoilsho	1445	10	maintained	maintain	VBN
cord-006229-7yoilsho	1445	11	by	by	IN
cord-006229-7yoilsho	1445	12	an	an	DT
cord-006229-7yoilsho	1445	13	imbalance	imbalance	NN
cord-006229-7yoilsho	1445	14	of	of	IN
cord-006229-7yoilsho	1445	15	receptor	receptor	NN
cord-006229-7yoilsho	1445	16	baised	baise	VBN
cord-006229-7yoilsho	1445	17	signaling	signaling	NN
cord-006229-7yoilsho	1445	18	;	;	:
cord-006229-7yoilsho	1445	19	the	the	DT
cord-006229-7yoilsho	1445	20	latter	latter	JJ
cord-006229-7yoilsho	1445	21	referring	refer	VBG
cord-006229-7yoilsho	1445	22	to	to	IN
cord-006229-7yoilsho	1445	23	the	the	DT
cord-006229-7yoilsho	1445	24	ability	ability	NN
cord-006229-7yoilsho	1445	25	of	of	IN
cord-006229-7yoilsho	1445	26	distinct	distinct	JJ
cord-006229-7yoilsho	1445	27	ligands	ligand	NNS
cord-006229-7yoilsho	1445	28	to	to	TO
cord-006229-7yoilsho	1445	29	endue	endue	VB
cord-006229-7yoilsho	1445	30	individual	individual	JJ
cord-006229-7yoilsho	1445	31	receptors	receptor	NNS
cord-006229-7yoilsho	1445	32	with	with	IN
cord-006229-7yoilsho	1445	33	qualitatively	qualitatively	RB
cord-006229-7yoilsho	1445	34	different	different	JJ
cord-006229-7yoilsho	1445	35	G	g	NN
cord-006229-7yoilsho	1445	36	-	-	HYPH
cord-006229-7yoilsho	1445	37	protein	protein	NN
cord-006229-7yoilsho	1445	38	-	-	HYPH
cord-006229-7yoilsho	1445	39	and	and	CC
cord-006229-7yoilsho	1445	40	/	/	SYM
cord-006229-7yoilsho	1445	41	or	or	CC
cord-006229-7yoilsho	1445	42	b	b	NN
cord-006229-7yoilsho	1445	43	-	-	HYPH
cord-006229-7yoilsho	1445	44	arrestindependent	arrestindependent	NN
cord-006229-7yoilsho	1445	45	signaling	signaling	NN
cord-006229-7yoilsho	1445	46	(	(	-LRB-
cord-006229-7yoilsho	1445	47	1	1	CD
cord-006229-7yoilsho	1445	48	)	)	-RRB-
cord-006229-7yoilsho	1445	49	.	.	.
cord-006229-7yoilsho	1446	1	Chemokines	Chemokines	NNPS
cord-006229-7yoilsho	1446	2	and	and	CC
cord-006229-7yoilsho	1446	3	their	-PRON-	PRP$
cord-006229-7yoilsho	1446	4	receptors	receptor	NNS
cord-006229-7yoilsho	1446	5	regulate	regulate	VBP
cord-006229-7yoilsho	1446	6	a	a	DT
cord-006229-7yoilsho	1446	7	wide	wide	JJ
cord-006229-7yoilsho	1446	8	array	array	NN
cord-006229-7yoilsho	1446	9	of	of	IN
cord-006229-7yoilsho	1446	10	leukocyte	leukocyte	NN
cord-006229-7yoilsho	1446	11	functions	function	NNS
cord-006229-7yoilsho	1446	12	,	,	,
cord-006229-7yoilsho	1446	13	including	include	VBG
cord-006229-7yoilsho	1446	14	chemotaxis	chemotaxis	NN
cord-006229-7yoilsho	1446	15	,	,	,
cord-006229-7yoilsho	1446	16	adhesion	adhesion	NN
cord-006229-7yoilsho	1446	17	,	,	,
cord-006229-7yoilsho	1446	18	and	and	CC
cord-006229-7yoilsho	1446	19	transendothelial	transendothelial	JJ
cord-006229-7yoilsho	1446	20	migration	migration	NN
cord-006229-7yoilsho	1446	21	,	,	,
cord-006229-7yoilsho	1446	22	and	and	CC
cord-006229-7yoilsho	1446	23	thus	thus	RB
cord-006229-7yoilsho	1446	24	play	play	VB
cord-006229-7yoilsho	1446	25	important	important	JJ
cord-006229-7yoilsho	1446	26	roles	role	NNS
cord-006229-7yoilsho	1446	27	in	in	IN
cord-006229-7yoilsho	1446	28	regulating	regulate	VBG
cord-006229-7yoilsho	1446	29	inflammation	inflammation	NN
cord-006229-7yoilsho	1446	30	(	(	-LRB-
cord-006229-7yoilsho	1446	31	2	2	CD
cord-006229-7yoilsho	1446	32	)	)	-RRB-
cord-006229-7yoilsho	1446	33	.	.	.
cord-006229-7yoilsho	1447	1	In	in	IN
cord-006229-7yoilsho	1447	2	man	man	NN
cord-006229-7yoilsho	1447	3	,	,	,
cord-006229-7yoilsho	1447	4	two	two	CD
cord-006229-7yoilsho	1447	5	CC	cc	NN
cord-006229-7yoilsho	1447	6	chemokine	chemokine	NN
cord-006229-7yoilsho	1447	7	receptors	receptor	NNS
cord-006229-7yoilsho	1447	8	CCR2a	CCR2a	NNP
cord-006229-7yoilsho	1447	9	and	and	CC
cord-006229-7yoilsho	1447	10	CCR2b	CCR2b	NNP
cord-006229-7yoilsho	1447	11	are	be	VBP
cord-006229-7yoilsho	1447	12	present	present	JJ
cord-006229-7yoilsho	1447	13	that	that	IN
cord-006229-7yoilsho	1447	14	only	only	RB
cord-006229-7yoilsho	1447	15	differ	differ	VBP
cord-006229-7yoilsho	1447	16	in	in	IN
cord-006229-7yoilsho	1447	17	their	-PRON-	PRP$
cord-006229-7yoilsho	1447	18	carboxyl	carboxyl	NN
cord-006229-7yoilsho	1447	19	terminal	terminal	NN
cord-006229-7yoilsho	1447	20	portions	portion	NNS
cord-006229-7yoilsho	1447	21	;	;	:
cord-006229-7yoilsho	1447	22	the	the	DT
cord-006229-7yoilsho	1447	23	latter	latter	RB
cord-006229-7yoilsho	1447	24	known	know	VBN
cord-006229-7yoilsho	1447	25	to	to	TO
cord-006229-7yoilsho	1447	26	interact	interact	VB
cord-006229-7yoilsho	1447	27	with	with	IN
cord-006229-7yoilsho	1447	28	multi	multi	JJ
cord-006229-7yoilsho	1447	29	-	-	JJ
cord-006229-7yoilsho	1447	30	protein	protein	JJ
cord-006229-7yoilsho	1447	31	complexes	complex	NNS
cord-006229-7yoilsho	1447	32	made	make	VBD
cord-006229-7yoilsho	1447	33	up	up	RP
cord-006229-7yoilsho	1447	34	of	of	IN
cord-006229-7yoilsho	1447	35	heterotrimeric	heterotrimeric	JJ
cord-006229-7yoilsho	1447	36	G	g	NN
cord-006229-7yoilsho	1447	37	proteins	protein	NNS
cord-006229-7yoilsho	1447	38	(	(	-LRB-
cord-006229-7yoilsho	1447	39	pertussis	pertussis	NN
cord-006229-7yoilsho	1447	40	toxin	toxin	NN
cord-006229-7yoilsho	1447	41	sensitive	sensitive	JJ
cord-006229-7yoilsho	1447	42	and	and	CC
cord-006229-7yoilsho	1447	43	-insensitive	-insensitive	JJ
cord-006229-7yoilsho	1447	44	)	)	-RRB-
cord-006229-7yoilsho	1447	45	and	and	CC
cord-006229-7yoilsho	1447	46	non	non	JJ
cord-006229-7yoilsho	1447	47	-	-	JJ
cord-006229-7yoilsho	1447	48	G	g	JJ
cord-006229-7yoilsho	1447	49	-	-	HYPH
cord-006229-7yoilsho	1447	50	protein	protein	NN
cord-006229-7yoilsho	1447	51	components	component	NNS
cord-006229-7yoilsho	1447	52	,	,	,
cord-006229-7yoilsho	1447	53	including	include	VBG
cord-006229-7yoilsho	1447	54	b	b	NN
cord-006229-7yoilsho	1447	55	-	-	:
cord-006229-7yoilsho	1447	56	arrestin	arrestin	NNP
cord-006229-7yoilsho	1447	57	(	(	-LRB-
cord-006229-7yoilsho	1447	58	2	2	CD
cord-006229-7yoilsho	1447	59	)	)	-RRB-
cord-006229-7yoilsho	1447	60	.	.	.
cord-006229-7yoilsho	1448	1	Interested	interested	JJ
cord-006229-7yoilsho	1448	2	in	in	IN
cord-006229-7yoilsho	1448	3	differential	differential	JJ
cord-006229-7yoilsho	1448	4	signaling	signaling	NN
cord-006229-7yoilsho	1448	5	of	of	IN
cord-006229-7yoilsho	1448	6	CCR2a	CCR2a	NNP
cord-006229-7yoilsho	1448	7	and	and	CC
cord-006229-7yoilsho	1448	8	CCR2b	CCR2b	NNP
cord-006229-7yoilsho	1449	1	we	-PRON-	PRP
cord-006229-7yoilsho	1449	2	comparatively	comparatively	RB
cord-006229-7yoilsho	1449	3	analyzed	analyze	VBD
cord-006229-7yoilsho	1449	4	ligand	ligand	NN
cord-006229-7yoilsho	1449	5	-	-	HYPH
cord-006229-7yoilsho	1449	6	induced	induce	VBN
cord-006229-7yoilsho	1449	7	G	g	NN
cord-006229-7yoilsho	1449	8	-	-	HYPH
cord-006229-7yoilsho	1449	9	protein	protein	NN
cord-006229-7yoilsho	1449	10	-	-	HYPH
cord-006229-7yoilsho	1449	11	regulated	regulate	VBN
cord-006229-7yoilsho	1449	12	signaling	signal	VBG
cord-006229-7yoilsho	1449	13	pathways	pathway	NNS
cord-006229-7yoilsho	1449	14	(	(	-LRB-
cord-006229-7yoilsho	1449	15	e.g.	e.g.	IN
cord-006229-7yoilsho	1449	16	activation	activation	NN
cord-006229-7yoilsho	1449	17	of	of	IN
cord-006229-7yoilsho	1449	18	phospholipase	phospholipase	NN
cord-006229-7yoilsho	1449	19	C	C	NNP
cord-006229-7yoilsho	1449	20	isoenzymes	isoenzyme	NNS
cord-006229-7yoilsho	1449	21	and	and	CC
cord-006229-7yoilsho	1449	22	RhoGTPase	rhogtpase	NN
cord-006229-7yoilsho	1449	23	-	-	HYPH
cord-006229-7yoilsho	1449	24	induced	induce	VBN
cord-006229-7yoilsho	1449	25	serum	serum	NN
cord-006229-7yoilsho	1449	26	response	response	NN
cord-006229-7yoilsho	1449	27	factor	factor	NN
cord-006229-7yoilsho	1449	28	[	[	-LRB-
cord-006229-7yoilsho	1449	29	SRF	SRF	NNP
cord-006229-7yoilsho	1449	30	]	]	-RRB-
cord-006229-7yoilsho	1449	31	activity	activity	NN
cord-006229-7yoilsho	1449	32	)	)	-RRB-
cord-006229-7yoilsho	1449	33	and	and	CC
cord-006229-7yoilsho	1449	34	b	b	LS
cord-006229-7yoilsho	1449	35	-	-	HYPH
cord-006229-7yoilsho	1449	36	arrestin	arrestin	RB
cord-006229-7yoilsho	1449	37	-	-	HYPH
cord-006229-7yoilsho	1449	38	regulated	regulate	VBN
cord-006229-7yoilsho	1449	39	pathways	pathway	NNS
cord-006229-7yoilsho	1449	40	(	(	-LRB-
cord-006229-7yoilsho	1449	41	e.g.	e.g.	RB
cord-006229-7yoilsho	1449	42	internalization	internalization	NN
cord-006229-7yoilsho	1449	43	of	of	IN
cord-006229-7yoilsho	1449	44	receptors	receptor	NNS
cord-006229-7yoilsho	1449	45	and	and	CC
cord-006229-7yoilsho	1449	46	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	1449	47	of	of	IN
cord-006229-7yoilsho	1449	48	ERK1/2	ERK1/2	NNP
cord-006229-7yoilsho	1449	49	)	)	-RRB-
cord-006229-7yoilsho	1449	50	in	in	IN
cord-006229-7yoilsho	1449	51	the	the	DT
cord-006229-7yoilsho	1449	52	presence	presence	NN
cord-006229-7yoilsho	1449	53	of	of	IN
cord-006229-7yoilsho	1449	54	CCL2	CCL2	NNP
cord-006229-7yoilsho	1449	55	,	,	,
cord-006229-7yoilsho	1449	56	CCL8	CCL8	NNP
cord-006229-7yoilsho	1449	57	,	,	,
cord-006229-7yoilsho	1449	58	CCL7	CCL7	NNP
cord-006229-7yoilsho	1449	59	,	,	,
cord-006229-7yoilsho	1449	60	and	and	CC
cord-006229-7yoilsho	1449	61	CCL13	CCL13	NNP
cord-006229-7yoilsho	1449	62	.	.	.
cord-006229-7yoilsho	1450	1	All	all	PDT
cord-006229-7yoilsho	1450	2	these	these	DT
cord-006229-7yoilsho	1450	3	chemokines	chemokine	NNS
cord-006229-7yoilsho	1450	4	have	have	VBP
cord-006229-7yoilsho	1450	5	been	be	VBN
cord-006229-7yoilsho	1450	6	shown	show	VBN
cord-006229-7yoilsho	1450	7	to	to	TO
cord-006229-7yoilsho	1450	8	interact	interact	VB
cord-006229-7yoilsho	1450	9	with	with	IN
cord-006229-7yoilsho	1450	10	human	human	JJ
cord-006229-7yoilsho	1450	11	CCR2	CCR2	NNP
cord-006229-7yoilsho	1450	12	receptors	receptor	NNS
cord-006229-7yoilsho	1450	13	.	.	.
cord-006229-7yoilsho	1451	1	In	in	IN
cord-006229-7yoilsho	1451	2	addition	addition	NN
cord-006229-7yoilsho	1451	3	,	,	,
cord-006229-7yoilsho	1451	4	the	the	DT
cord-006229-7yoilsho	1451	5	structural	structural	JJ
cord-006229-7yoilsho	1451	6	requirements	requirement	NNS
cord-006229-7yoilsho	1451	7	of	of	IN
cord-006229-7yoilsho	1451	8	the	the	DT
cord-006229-7yoilsho	1451	9	carboxyl	carboxyl	NN
cord-006229-7yoilsho	1451	10	terminal	terminal	NN
cord-006229-7yoilsho	1451	11	portions	portion	NNS
cord-006229-7yoilsho	1451	12	involved	involve	VBN
cord-006229-7yoilsho	1451	13	in	in	IN
cord-006229-7yoilsho	1451	14	determining	determine	VBG
cord-006229-7yoilsho	1451	15	specificity	specificity	NN
cord-006229-7yoilsho	1451	16	in	in	IN
cord-006229-7yoilsho	1451	17	G	g	NN
cord-006229-7yoilsho	1451	18	-	-	HYPH
cord-006229-7yoilsho	1451	19	protein	protein	NN
cord-006229-7yoilsho	1451	20	-	-	HYPH
cord-006229-7yoilsho	1451	21	dependent	dependent	JJ
cord-006229-7yoilsho	1451	22	signaling	signaling	NN
cord-006229-7yoilsho	1451	23	was	be	VBD
cord-006229-7yoilsho	1451	24	addressed	address	VBN
cord-006229-7yoilsho	1451	25	by	by	IN
cord-006229-7yoilsho	1451	26	using	use	VBG
cord-006229-7yoilsho	1451	27	CCR2	CCR2	NNP
cord-006229-7yoilsho	1451	28	receptor	receptor	NN
cord-006229-7yoilsho	1451	29	mutants	mutant	NNS
cord-006229-7yoilsho	1451	30	.	.	.
cord-006229-7yoilsho	1452	1	The	the	DT
cord-006229-7yoilsho	1452	2	comparative	comparative	JJ
cord-006229-7yoilsho	1452	3	analysis	analysis	NN
cord-006229-7yoilsho	1452	4	revealed	reveal	VBD
cord-006229-7yoilsho	1452	5	that	that	IN
cord-006229-7yoilsho	1452	6	differences	difference	NNS
cord-006229-7yoilsho	1452	7	in	in	IN
cord-006229-7yoilsho	1452	8	ligand	ligand	NN
cord-006229-7yoilsho	1452	9	-	-	HYPH
cord-006229-7yoilsho	1452	10	induced	induce	VBN
cord-006229-7yoilsho	1452	11	activation	activation	NN
cord-006229-7yoilsho	1452	12	of	of	IN
cord-006229-7yoilsho	1452	13	G	g	NN
cord-006229-7yoilsho	1452	14	-	-	HYPH
cord-006229-7yoilsho	1452	15	protein	protein	NN
cord-006229-7yoilsho	1452	16	-	-	HYPH
cord-006229-7yoilsho	1452	17	dependent	dependent	JJ
cord-006229-7yoilsho	1452	18	(	(	-LRB-
cord-006229-7yoilsho	1452	19	pertussis	pertussis	NN
cord-006229-7yoilsho	1452	20	-	-	HYPH
cord-006229-7yoilsho	1452	21	toxin	toxin	NN
cord-006229-7yoilsho	1452	22	-	-	HYPH
cord-006229-7yoilsho	1452	23	sensitive	sensitive	JJ
cord-006229-7yoilsho	1452	24	versus	versus	IN
cord-006229-7yoilsho	1452	25	pertussis	pertussis	NN
cord-006229-7yoilsho	1452	26	-	-	HYPH
cord-006229-7yoilsho	1452	27	toxin	toxin	NN
cord-006229-7yoilsho	1452	28	-	-	HYPH
cord-006229-7yoilsho	1452	29	insensitive	insensitive	JJ
cord-006229-7yoilsho	1452	30	)	)	-RRB-
cord-006229-7yoilsho	1452	31	and/or	and/or	CC
cord-006229-7yoilsho	1452	32	b	b	LS
cord-006229-7yoilsho	1452	33	-	-	HYPH
cord-006229-7yoilsho	1452	34	arrestin	arrestin	JJ
cord-006229-7yoilsho	1452	35	-	-	HYPH
cord-006229-7yoilsho	1452	36	dependent	dependent	JJ
cord-006229-7yoilsho	1452	37	signaling	signaling	NN
cord-006229-7yoilsho	1452	38	exist	exist	VBP
cord-006229-7yoilsho	1452	39	.	.	.
cord-006229-7yoilsho	1453	1	For	for	IN
cord-006229-7yoilsho	1453	2	example	example	NN
cord-006229-7yoilsho	1453	3	,	,	,
cord-006229-7yoilsho	1453	4	activation	activation	NN
cord-006229-7yoilsho	1453	5	of	of	IN
cord-006229-7yoilsho	1453	6	CCR2b	CCR2b	NNP
cord-006229-7yoilsho	1453	7	receptors	receptor	NNS
cord-006229-7yoilsho	1453	8	by	by	IN
cord-006229-7yoilsho	1453	9	CCL2	CCL2	NNP
cord-006229-7yoilsho	1453	10	induced	induce	VBD
cord-006229-7yoilsho	1453	11	both	both	CC
cord-006229-7yoilsho	1453	12	Rho	rho	NN
cord-006229-7yoilsho	1453	13	-	-	HYPH
cord-006229-7yoilsho	1453	14	dependent	dependent	JJ
cord-006229-7yoilsho	1453	15	SRF	SRF	NNP
cord-006229-7yoilsho	1453	16	activation	activation	NN
cord-006229-7yoilsho	1453	17	and	and	CC
cord-006229-7yoilsho	1453	18	receptor	receptor	NN
cord-006229-7yoilsho	1453	19	internalization	internalization	NN
cord-006229-7yoilsho	1453	20	,	,	,
cord-006229-7yoilsho	1453	21	while	while	IN
cord-006229-7yoilsho	1453	22	CCL8-stimulation	ccl8-stimulation	NN
cord-006229-7yoilsho	1453	23	resulted	result	VBD
cord-006229-7yoilsho	1453	24	in	in	IN
cord-006229-7yoilsho	1453	25	SRF	SRF	NNP
cord-006229-7yoilsho	1453	26	but	but	CC
cord-006229-7yoilsho	1453	27	little	little	JJ
cord-006229-7yoilsho	1453	28	if	if	IN
cord-006229-7yoilsho	1453	29	any	any	DT
cord-006229-7yoilsho	1453	30	receptor	receptor	NN
cord-006229-7yoilsho	1453	31	internalization	internalization	NN
cord-006229-7yoilsho	1453	32	.	.	.
cord-006229-7yoilsho	1454	1	In	in	IN
cord-006229-7yoilsho	1454	2	contrast	contrast	NN
cord-006229-7yoilsho	1454	3	,	,	,
cord-006229-7yoilsho	1454	4	CCR2a	CCR2a	NNP
cord-006229-7yoilsho	1454	5	-	-	HYPH
cord-006229-7yoilsho	1454	6	expressing	express	VBG
cord-006229-7yoilsho	1454	7	cells	cell	NNS
cord-006229-7yoilsho	1454	8	showed	show	VBD
cord-006229-7yoilsho	1454	9	CCL2dependent	CCL2dependent	NNP
cord-006229-7yoilsho	1454	10	SRF	SRF	NNP
cord-006229-7yoilsho	1454	11	-	-	HYPH
cord-006229-7yoilsho	1454	12	activation	activation	NN
cord-006229-7yoilsho	1454	13	but	but	CC
cord-006229-7yoilsho	1454	14	any	any	DT
cord-006229-7yoilsho	1454	15	receptor	receptor	NN
cord-006229-7yoilsho	1454	16	/	/	SYM
cord-006229-7yoilsho	1454	17	ligand	ligand	NN
cord-006229-7yoilsho	1454	18	internalization	internalization	NN
cord-006229-7yoilsho	1454	19	.	.	.
cord-006229-7yoilsho	1455	1	Analysis	analysis	NN
cord-006229-7yoilsho	1455	2	of	of	IN
cord-006229-7yoilsho	1455	3	the	the	DT
cord-006229-7yoilsho	1455	4	structural	structural	JJ
cord-006229-7yoilsho	1455	5	requirements	requirement	NNS
cord-006229-7yoilsho	1455	6	of	of	IN
cord-006229-7yoilsho	1455	7	CCR2	CCR2	NNP
cord-006229-7yoilsho	1455	8	receptors	receptor	NNS
cord-006229-7yoilsho	1455	9	for	for	IN
cord-006229-7yoilsho	1455	10	coupling	couple	VBG
cord-006229-7yoilsho	1455	11	to	to	IN
cord-006229-7yoilsho	1455	12	G	g	NN
cord-006229-7yoilsho	1455	13	proteins	protein	NNS
cord-006229-7yoilsho	1455	14	revealed	reveal	VBD
cord-006229-7yoilsho	1455	15	that	that	IN
cord-006229-7yoilsho	1455	16	arginine	arginine	NN
cord-006229-7yoilsho	1455	17	313	313	CD
cord-006229-7yoilsho	1455	18	within	within	IN
cord-006229-7yoilsho	1455	19	the	the	DT
cord-006229-7yoilsho	1455	20	putative	putative	JJ
cord-006229-7yoilsho	1455	21	'	'	``
cord-006229-7yoilsho	1455	22	eighth	eighth	JJ
cord-006229-7yoilsho	1455	23	helix	helix	NN
cord-006229-7yoilsho	1455	24	'	'	''
cord-006229-7yoilsho	1455	25	of	of	IN
cord-006229-7yoilsho	1455	26	the	the	DT
cord-006229-7yoilsho	1455	27	carboxyl	carboxyl	NN
cord-006229-7yoilsho	1455	28	-	-	HYPH
cord-006229-7yoilsho	1455	29	terminal	terminal	NN
cord-006229-7yoilsho	1455	30	portions	portion	NNS
cord-006229-7yoilsho	1455	31	of	of	IN
cord-006229-7yoilsho	1455	32	CCR2a	CCR2a	NNP
cord-006229-7yoilsho	1455	33	and	and	CC
cord-006229-7yoilsho	1455	34	CCR2b	CCR2b	NNP
cord-006229-7yoilsho	1455	35	is	be	VBZ
cord-006229-7yoilsho	1455	36	not	not	RB
cord-006229-7yoilsho	1455	37	involved	involve	VBN
cord-006229-7yoilsho	1455	38	in	in	IN
cord-006229-7yoilsho	1455	39	Ga	Ga	NNP
cord-006229-7yoilsho	1455	40	i	i	CD
cord-006229-7yoilsho	1455	41	-mediated	-mediated	JJ
cord-006229-7yoilsho	1455	42	induction	induction	NN
cord-006229-7yoilsho	1455	43	of	of	IN
cord-006229-7yoilsho	1455	44	ERK1/2	ERK1/2	NNP
cord-006229-7yoilsho	1455	45	and	and	CC
cord-006229-7yoilsho	1455	46	plays	play	VBZ
cord-006229-7yoilsho	1455	47	a	a	DT
cord-006229-7yoilsho	1455	48	minor	minor	JJ
cord-006229-7yoilsho	1455	49	role	role	NN
cord-006229-7yoilsho	1455	50	in	in	IN
cord-006229-7yoilsho	1455	51	CCR2b	CCR2b	NNP
cord-006229-7yoilsho	1455	52	receptor	receptor	NN
cord-006229-7yoilsho	1455	53	internalization	internalization	NN
cord-006229-7yoilsho	1455	54	,	,	,
cord-006229-7yoilsho	1455	55	but	but	CC
cord-006229-7yoilsho	1455	56	is	be	VBZ
cord-006229-7yoilsho	1455	57	specifically	specifically	RB
cord-006229-7yoilsho	1455	58	required	require	VBN
cord-006229-7yoilsho	1455	59	for	for	IN
cord-006229-7yoilsho	1455	60	the	the	DT
cord-006229-7yoilsho	1455	61	CCR2a/	ccr2a/	NN
cord-006229-7yoilsho	1456	1	and	and	CC
cord-006229-7yoilsho	1456	2	CCR2b	CCR2b	NNP
cord-006229-7yoilsho	1457	1	/Ga	/Ga	NNP
cord-006229-7yoilsho	1457	2	q	q	NNP
cord-006229-7yoilsho	1457	3	-mediated	-mediated	NNP
cord-006229-7yoilsho	1457	4	activation	activation	NN
cord-006229-7yoilsho	1457	5	of	of	IN
cord-006229-7yoilsho	1457	6	SRF	SRF	NNP
cord-006229-7yoilsho	1457	7	.	.	.
cord-006229-7yoilsho	1458	1	Serotonin	serotonin	NN
cord-006229-7yoilsho	1458	2	5-HT	5-ht	CD
cord-006229-7yoilsho	1458	3	2C	2C	NNP
cord-006229-7yoilsho	1458	4	receptors	receptor	NNS
cord-006229-7yoilsho	1458	5	(	(	-LRB-
cord-006229-7yoilsho	1458	6	5-HT	5-ht	CD
cord-006229-7yoilsho	1458	7	2C	2C	NNP
cord-006229-7yoilsho	1458	8	R	R	NNP
cord-006229-7yoilsho	1458	9	)	)	-RRB-
cord-006229-7yoilsho	1458	10	are	be	VBP
cord-006229-7yoilsho	1458	11	functional	functional	JJ
cord-006229-7yoilsho	1458	12	engaged	engage	VBN
cord-006229-7yoilsho	1458	13	with	with	IN
cord-006229-7yoilsho	1458	14	Gq	Gq	NNP
cord-006229-7yoilsho	1458	15	proteins	protein	NNS
cord-006229-7yoilsho	1458	16	and	and	CC
cord-006229-7yoilsho	1458	17	expressed	express	VBN
cord-006229-7yoilsho	1458	18	in	in	IN
cord-006229-7yoilsho	1458	19	the	the	DT
cord-006229-7yoilsho	1458	20	central	central	JJ
cord-006229-7yoilsho	1458	21	nervous	nervous	JJ
cord-006229-7yoilsho	1458	22	system	system	NN
cord-006229-7yoilsho	1458	23	(	(	-LRB-
cord-006229-7yoilsho	1458	24	CNS	CNS	NNP
cord-006229-7yoilsho	1458	25	)	)	-RRB-
cord-006229-7yoilsho	1458	26	.	.	.
cord-006229-7yoilsho	1459	1	5-HT	5-ht	CD
cord-006229-7yoilsho	1459	2	2C	2C	NNP
cord-006229-7yoilsho	1459	3	R	R	NNP
cord-006229-7yoilsho	1459	4	significantly	significantly	RB
cord-006229-7yoilsho	1459	5	regulate	regulate	VBP
cord-006229-7yoilsho	1459	6	emotion	emotion	NN
cord-006229-7yoilsho	1459	7	,	,	,
cord-006229-7yoilsho	1459	8	feeding	feeding	NN
cord-006229-7yoilsho	1459	9	,	,	,
cord-006229-7yoilsho	1459	10	reward	reward	NN
cord-006229-7yoilsho	1459	11	or	or	CC
cord-006229-7yoilsho	1459	12	cognition	cognition	NN
cord-006229-7yoilsho	1459	13	and	and	CC
cord-006229-7yoilsho	1459	14	thus	thus	RB
cord-006229-7yoilsho	1459	15	might	may	MD
cord-006229-7yoilsho	1459	16	serve	serve	VB
cord-006229-7yoilsho	1459	17	as	as	IN
cord-006229-7yoilsho	1459	18	promising	promising	JJ
cord-006229-7yoilsho	1459	19	targets	target	NNS
cord-006229-7yoilsho	1459	20	for	for	IN
cord-006229-7yoilsho	1459	21	drugs	drug	NNS
cord-006229-7yoilsho	1459	22	against	against	IN
cord-006229-7yoilsho	1459	23	psychiatric	psychiatric	JJ
cord-006229-7yoilsho	1459	24	disorders	disorder	NNS
cord-006229-7yoilsho	1459	25	or	or	CC
cord-006229-7yoilsho	1459	26	obesity	obesity	NN
cord-006229-7yoilsho	1459	27	.	.	.
cord-006229-7yoilsho	1460	1	Due	due	IN
cord-006229-7yoilsho	1460	2	to	to	IN
cord-006229-7yoilsho	1460	3	the	the	DT
cord-006229-7yoilsho	1460	4	technical	technical	JJ
cord-006229-7yoilsho	1460	5	difficulties	difficulty	NNS
cord-006229-7yoilsho	1460	6	in	in	IN
cord-006229-7yoilsho	1460	7	isolating	isolate	VBG
cord-006229-7yoilsho	1460	8	cells	cell	NNS
cord-006229-7yoilsho	1460	9	from	from	IN
cord-006229-7yoilsho	1460	10	the	the	DT
cord-006229-7yoilsho	1460	11	CNS	CNS	NNP
cord-006229-7yoilsho	1460	12	and	and	CC
cord-006229-7yoilsho	1460	13	the	the	DT
cord-006229-7yoilsho	1460	14	hitherto	hitherto	JJ
cord-006229-7yoilsho	1460	15	lack	lack	NN
cord-006229-7yoilsho	1460	16	of	of	IN
cord-006229-7yoilsho	1460	17	suitable	suitable	JJ
cord-006229-7yoilsho	1460	18	cell	cell	NN
cord-006229-7yoilsho	1460	19	lines	line	NNS
cord-006229-7yoilsho	1460	20	that	that	WDT
cord-006229-7yoilsho	1460	21	would	would	MD
cord-006229-7yoilsho	1460	22	endogenously	endogenously	RB
cord-006229-7yoilsho	1460	23	express	express	VB
cord-006229-7yoilsho	1460	24	5-HT	5-ht	CD
cord-006229-7yoilsho	1460	25	2C	2C	NNP
cord-006229-7yoilsho	1460	26	R	R	NNP
cord-006229-7yoilsho	1460	27	,	,	,
cord-006229-7yoilsho	1460	28	our	-PRON-	PRP$
cord-006229-7yoilsho	1460	29	knowledge	knowledge	NN
cord-006229-7yoilsho	1460	30	about	about	IN
cord-006229-7yoilsho	1460	31	this	this	DT
cord-006229-7yoilsho	1460	32	receptor	receptor	NN
cord-006229-7yoilsho	1460	33	subtype	subtype	NN
cord-006229-7yoilsho	1460	34	is	be	VBZ
cord-006229-7yoilsho	1460	35	rather	rather	RB
cord-006229-7yoilsho	1460	36	limited	limited	JJ
cord-006229-7yoilsho	1460	37	.	.	.
cord-006229-7yoilsho	1461	1	Recently	recently	RB
cord-006229-7yoilsho	1461	2	established	establish	VBD
cord-006229-7yoilsho	1461	3	hypothalamic	hypothalamic	JJ
cord-006229-7yoilsho	1461	4	mHypoA2	mHypoA2	NNP
cord-006229-7yoilsho	1461	5	-	-	SYM
cord-006229-7yoilsho	1461	6	10	10	CD
cord-006229-7yoilsho	1461	7	cells	cell	NNS
cord-006229-7yoilsho	1461	8	show	show	VBP
cord-006229-7yoilsho	1461	9	some	some	DT
cord-006229-7yoilsho	1461	10	characteristics	characteristic	NNS
cord-006229-7yoilsho	1461	11	of	of	IN
cord-006229-7yoilsho	1461	12	appetite	appetite	NN
cord-006229-7yoilsho	1461	13	-	-	HYPH
cord-006229-7yoilsho	1461	14	regulating	regulate	VBG
cord-006229-7yoilsho	1461	15	hypothalamic	hypothalamic	JJ
cord-006229-7yoilsho	1461	16	neurons	neuron	NNS
cord-006229-7yoilsho	1461	17	of	of	IN
cord-006229-7yoilsho	1461	18	the	the	DT
cord-006229-7yoilsho	1461	19	paraventricular	paraventricular	NNP
cord-006229-7yoilsho	1461	20	nucleus	nucleus	NNP
cord-006229-7yoilsho	1461	21	,	,	,
cord-006229-7yoilsho	1461	22	where	where	WRB
cord-006229-7yoilsho	1461	23	5-HT	5-ht	CD
cord-006229-7yoilsho	1461	24	2C	2C	NNP
cord-006229-7yoilsho	1461	25	R	R	NNP
cord-006229-7yoilsho	1461	26	in	in	IN
cord-006229-7yoilsho	1461	27	vivo	vivo	NN
cord-006229-7yoilsho	1461	28	expression	expression	NN
cord-006229-7yoilsho	1461	29	has	have	VBZ
cord-006229-7yoilsho	1461	30	been	be	VBN
cord-006229-7yoilsho	1461	31	detected	detect	VBN
cord-006229-7yoilsho	1461	32	.	.	.
cord-006229-7yoilsho	1462	1	Thus	thus	RB
cord-006229-7yoilsho	1462	2	,	,	,
cord-006229-7yoilsho	1462	3	we	-PRON-	PRP
cord-006229-7yoilsho	1462	4	tested	test	VBD
cord-006229-7yoilsho	1462	5	mHypoA2	mHypoA2	NNP
cord-006229-7yoilsho	1462	6	-	-	SYM
cord-006229-7yoilsho	1462	7	10	10	CD
cord-006229-7yoilsho	1462	8	cells	cell	NNS
cord-006229-7yoilsho	1462	9	for	for	IN
cord-006229-7yoilsho	1462	10	putative	putative	JJ
cord-006229-7yoilsho	1462	11	5-HT	5-ht	CD
cord-006229-7yoilsho	1462	12	2C	2C	NNP
cord-006229-7yoilsho	1462	13	R	r	NN
cord-006229-7yoilsho	1462	14	expression	expression	NN
cord-006229-7yoilsho	1462	15	by	by	IN
cord-006229-7yoilsho	1462	16	performing	perform	VBG
cord-006229-7yoilsho	1462	17	single	single	JJ
cord-006229-7yoilsho	1462	18	cell	cell	NN
cord-006229-7yoilsho	1462	19	calcium	calcium	NN
cord-006229-7yoilsho	1462	20	imaging	imaging	NN
cord-006229-7yoilsho	1462	21	.	.	.
cord-006229-7yoilsho	1463	1	We	-PRON-	PRP
cord-006229-7yoilsho	1463	2	observed	observe	VBD
cord-006229-7yoilsho	1463	3	that	that	IN
cord-006229-7yoilsho	1463	4	serotonin	serotonin	NN
cord-006229-7yoilsho	1463	5	and	and	CC
cord-006229-7yoilsho	1463	6	the	the	DT
cord-006229-7yoilsho	1463	7	specific	specific	JJ
cord-006229-7yoilsho	1463	8	5-HT	5-ht	CD
cord-006229-7yoilsho	1463	9	2C	2C	NNP
cord-006229-7yoilsho	1463	10	R	r	NN
cord-006229-7yoilsho	1463	11	agonist	agonist	NN
cord-006229-7yoilsho	1463	12	,	,	,
cord-006229-7yoilsho	1463	13	WAY161,503	WAY161,503	NNP
cord-006229-7yoilsho	1463	14	induced	induce	VBD
cord-006229-7yoilsho	1463	15	robust	robust	JJ
cord-006229-7yoilsho	1463	16	calcium	calcium	NN
cord-006229-7yoilsho	1463	17	transients	transient	NNS
cord-006229-7yoilsho	1463	18	,	,	,
cord-006229-7yoilsho	1463	19	which	which	WDT
cord-006229-7yoilsho	1463	20	were	be	VBD
cord-006229-7yoilsho	1463	21	strongly	strongly	RB
cord-006229-7yoilsho	1463	22	inhibited	inhibit	VBN
cord-006229-7yoilsho	1463	23	by	by	IN
cord-006229-7yoilsho	1463	24	two	two	CD
cord-006229-7yoilsho	1463	25	unrelated	unrelated	JJ
cord-006229-7yoilsho	1463	26	5-HT	5-ht	CD
cord-006229-7yoilsho	1463	27	2C	2C	NNP
cord-006229-7yoilsho	1463	28	R	r	NN
cord-006229-7yoilsho	1463	29	-	-	HYPH
cord-006229-7yoilsho	1463	30	selective	selective	JJ
cord-006229-7yoilsho	1463	31	antagonist	antagonist	NN
cord-006229-7yoilsho	1463	32	(	(	-LRB-
cord-006229-7yoilsho	1463	33	SB206,553	sb206,553	NN
cord-006229-7yoilsho	1463	34	,	,	,
cord-006229-7yoilsho	1463	35	RS102,221	RS102,221	NNP
cord-006229-7yoilsho	1463	36	)	)	-RRB-
cord-006229-7yoilsho	1463	37	.	.	.
cord-006229-7yoilsho	1464	1	Serotonin	serotonin	NN
cord-006229-7yoilsho	1464	2	and	and	CC
cord-006229-7yoilsho	1464	3	WAY161,503	WAY161,503	NNP
cord-006229-7yoilsho	1464	4	also	also	RB
cord-006229-7yoilsho	1464	5	activated	activate	VBD
cord-006229-7yoilsho	1464	6	a	a	DT
cord-006229-7yoilsho	1464	7	cAMP	camp	NN
cord-006229-7yoilsho	1464	8	response	response	NN
cord-006229-7yoilsho	1464	9	element	element	NN
cord-006229-7yoilsho	1464	10	-	-	HYPH
cord-006229-7yoilsho	1464	11	dependent	dependent	JJ
cord-006229-7yoilsho	1464	12	reporter	reporter	NN
cord-006229-7yoilsho	1464	13	gene	gene	NN
cord-006229-7yoilsho	1464	14	construct	construct	NN
cord-006229-7yoilsho	1464	15	and	and	CC
cord-006229-7yoilsho	1464	16	induced	induce	VBN
cord-006229-7yoilsho	1464	17	significant	significant	JJ
cord-006229-7yoilsho	1464	18	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	1464	19	of	of	IN
cord-006229-7yoilsho	1464	20	extracellularregulated	extracellularregulate	VBN
cord-006229-7yoilsho	1464	21	kinases-1/2	kinases-1/2	NNP
cord-006229-7yoilsho	1464	22	in	in	IN
cord-006229-7yoilsho	1464	23	a	a	DT
cord-006229-7yoilsho	1464	24	SB206,553	sb206,553	NN
cord-006229-7yoilsho	1464	25	and	and	CC
cord-006229-7yoilsho	1464	26	RS102,221	rs102,221	NN
cord-006229-7yoilsho	1464	27	sensitive	sensitive	JJ
cord-006229-7yoilsho	1464	28	manner	manner	NN
cord-006229-7yoilsho	1464	29	,	,	,
cord-006229-7yoilsho	1464	30	providing	provide	VBG
cord-006229-7yoilsho	1464	31	further	further	JJ
cord-006229-7yoilsho	1464	32	evidence	evidence	NN
cord-006229-7yoilsho	1464	33	for	for	IN
cord-006229-7yoilsho	1464	34	functional	functional	JJ
cord-006229-7yoilsho	1464	35	5-HT	5-ht	CD
cord-006229-7yoilsho	1464	36	2C	2C	NNP
cord-006229-7yoilsho	1464	37	R	r	NN
cord-006229-7yoilsho	1464	38	expression	expression	NN
cord-006229-7yoilsho	1464	39	in	in	IN
cord-006229-7yoilsho	1464	40	mHypoA-2/10	mHypoA-2/10	NNP
cord-006229-7yoilsho	1464	41	cells	cell	NNS
cord-006229-7yoilsho	1464	42	.	.	.
cord-006229-7yoilsho	1465	1	Intrinsic	intrinsic	JJ
cord-006229-7yoilsho	1465	2	activity	activity	NN
cord-006229-7yoilsho	1465	3	of	of	IN
cord-006229-7yoilsho	1465	4	WAY161,503	WAY161,503	NNP
cord-006229-7yoilsho	1465	5	ranged	range	VBD
cord-006229-7yoilsho	1465	6	between	between	IN
cord-006229-7yoilsho	1465	7	0.3	0.3	CD
cord-006229-7yoilsho	1465	8	and	and	CC
cord-006229-7yoilsho	1465	9	0.5	0.5	CD
cord-006229-7yoilsho	1465	10	compared	compare	VBN
cord-006229-7yoilsho	1465	11	to	to	IN
cord-006229-7yoilsho	1465	12	serotonin	serotonin	NN
cord-006229-7yoilsho	1465	13	in	in	IN
cord-006229-7yoilsho	1465	14	all	all	DT
cord-006229-7yoilsho	1465	15	assays	assay	NNS
cord-006229-7yoilsho	1465	16	,	,	,
cord-006229-7yoilsho	1465	17	defining	define	VBG
cord-006229-7yoilsho	1465	18	WAY161,503	WAY161,503	NNP
cord-006229-7yoilsho	1465	19	as	as	IN
cord-006229-7yoilsho	1465	20	a	a	DT
cord-006229-7yoilsho	1465	21	partial	partial	JJ
cord-006229-7yoilsho	1465	22	5-HT	5-ht	CD
cord-006229-7yoilsho	1465	23	2C	2C	NNP
cord-006229-7yoilsho	1465	24	R	r	NN
cord-006229-7yoilsho	1465	25	agonist	agonist	NN
cord-006229-7yoilsho	1465	26	.	.	.
cord-006229-7yoilsho	1466	1	In	in	IN
cord-006229-7yoilsho	1466	2	conclusion	conclusion	NN
cord-006229-7yoilsho	1466	3	,	,	,
cord-006229-7yoilsho	1466	4	we	-PRON-	PRP
cord-006229-7yoilsho	1466	5	provide	provide	VBP
cord-006229-7yoilsho	1466	6	convincing	convincing	JJ
cord-006229-7yoilsho	1466	7	data	datum	NNS
cord-006229-7yoilsho	1466	8	that	that	IN
cord-006229-7yoilsho	1466	9	hypothalamic	hypothalamic	JJ
cord-006229-7yoilsho	1466	10	mHypoA-2/10	mHypoA-2/10	NNP
cord-006229-7yoilsho	1466	11	cells	cell	NNS
cord-006229-7yoilsho	1466	12	endogenously	endogenously	RB
cord-006229-7yoilsho	1466	13	express	express	VBP
cord-006229-7yoilsho	1466	14	5-HT	5-ht	CD
cord-006229-7yoilsho	1466	15	2C	2C	NNP
cord-006229-7yoilsho	1466	16	R	r	NN
cord-006229-7yoilsho	1466	17	and	and	CC
cord-006229-7yoilsho	1466	18	thus	thus	RB
cord-006229-7yoilsho	1466	19	represent	represent	VB
cord-006229-7yoilsho	1466	20	the	the	DT
cord-006229-7yoilsho	1466	21	first	first	JJ
cord-006229-7yoilsho	1466	22	cell	cell	NN
cord-006229-7yoilsho	1466	23	line	line	NN
cord-006229-7yoilsho	1466	24	to	to	TO
cord-006229-7yoilsho	1466	25	analyse	analyse	VB
cord-006229-7yoilsho	1466	26	5-HT	5-ht	CD
cord-006229-7yoilsho	1466	27	2C	2C	NNP
cord-006229-7yoilsho	1466	28	R	R	NNP
cord-006229-7yoilsho	1466	29	pharmacology	pharmacology	NN
cord-006229-7yoilsho	1466	30	,	,	,
cord-006229-7yoilsho	1466	31	signaling	signaling	NN
cord-006229-7yoilsho	1466	32	and	and	CC
cord-006229-7yoilsho	1466	33	regulation	regulation	NN
cord-006229-7yoilsho	1466	34	in	in	IN
cord-006229-7yoilsho	1466	35	its	-PRON-	PRP$
cord-006229-7yoilsho	1466	36	natural	natural	JJ
cord-006229-7yoilsho	1466	37	environment	environment	NN
cord-006229-7yoilsho	1466	38	.	.	.
cord-006229-7yoilsho	1467	1	Optical	optical	JJ
cord-006229-7yoilsho	1467	2	and	and	CC
cord-006229-7yoilsho	1467	3	electrophysiological	electrophysiological	JJ
cord-006229-7yoilsho	1467	4	methods	method	NNS
cord-006229-7yoilsho	1467	5	allow	allow	VBP
cord-006229-7yoilsho	1467	6	detection	detection	NN
cord-006229-7yoilsho	1467	7	and	and	CC
cord-006229-7yoilsho	1467	8	characterization	characterization	NN
cord-006229-7yoilsho	1467	9	of	of	IN
cord-006229-7yoilsho	1467	10	G	g	NN
cord-006229-7yoilsho	1467	11	i	i	NN
cord-006229-7yoilsho	1467	12	/	/	SYM
cord-006229-7yoilsho	1467	13	o	o	NN
cord-006229-7yoilsho	1467	14	-protein	-protein	CC
cord-006229-7yoilsho	1467	15	coupled	couple	VBN
cord-006229-7yoilsho	1467	16	receptors	receptor	NNS
cord-006229-7yoilsho	1467	17	J.	J.	NNP
cord-006229-7yoilsho	1467	18	Straub	Straub	NNP
cord-006229-7yoilsho	1467	19	1	1	CD
cord-006229-7yoilsho	1467	20	1	1	CD
cord-006229-7yoilsho	1467	21	Walther	Walther	NNP
cord-006229-7yoilsho	1467	22	-	-	HYPH
cord-006229-7yoilsho	1467	23	Straub	Straub	NNP
cord-006229-7yoilsho	1467	24	-	-	HYPH
cord-006229-7yoilsho	1467	25	Institut	Institut	NNP
cord-006229-7yoilsho	1467	26	für	für	NNP
cord-006229-7yoilsho	1467	27	Pharmakologie	Pharmakologie	NNP
cord-006229-7yoilsho	1467	28	und	und	XX
cord-006229-7yoilsho	1468	1	Toxikologie	Toxikologie	NNP
cord-006229-7yoilsho	1468	2	,	,	,
cord-006229-7yoilsho	1468	3	München	München	NNP
cord-006229-7yoilsho	1468	4	,	,	,
cord-006229-7yoilsho	1469	1	Germany	Germany	NNP
cord-006229-7yoilsho	1469	2	G	G	NNP
cord-006229-7yoilsho	1469	3	-	-	HYPH
cord-006229-7yoilsho	1469	4	protein	protein	NN
cord-006229-7yoilsho	1469	5	mediated	mediate	VBD
cord-006229-7yoilsho	1469	6	signaling	signal	VBG
cord-006229-7yoilsho	1469	7	pathways	pathway	NNS
cord-006229-7yoilsho	1469	8	are	be	VBP
cord-006229-7yoilsho	1469	9	essential	essential	JJ
cord-006229-7yoilsho	1469	10	components	component	NNS
cord-006229-7yoilsho	1469	11	of	of	IN
cord-006229-7yoilsho	1469	12	basic	basic	JJ
cord-006229-7yoilsho	1469	13	cellular	cellular	JJ
cord-006229-7yoilsho	1469	14	functions	function	NNS
cord-006229-7yoilsho	1469	15	.	.	.
cord-006229-7yoilsho	1470	1	Of	of	IN
cord-006229-7yoilsho	1470	2	note	note	NN
cord-006229-7yoilsho	1470	3	,	,	,
cord-006229-7yoilsho	1470	4	G	g	NN
cord-006229-7yoilsho	1470	5	-	-	HYPH
cord-006229-7yoilsho	1470	6	protein	protein	NN
cord-006229-7yoilsho	1470	7	coupled	coupled	JJ
cord-006229-7yoilsho	1470	8	receptors	receptor	NNS
cord-006229-7yoilsho	1470	9	(	(	-LRB-
cord-006229-7yoilsho	1470	10	GPCRs	GPCRs	NNP
cord-006229-7yoilsho	1470	11	)	)	-RRB-
cord-006229-7yoilsho	1470	12	constitute	constitute	VBP
cord-006229-7yoilsho	1470	13	one	one	CD
cord-006229-7yoilsho	1470	14	of	of	IN
cord-006229-7yoilsho	1470	15	the	the	DT
cord-006229-7yoilsho	1470	16	major	major	JJ
cord-006229-7yoilsho	1470	17	drug	drug	NN
cord-006229-7yoilsho	1470	18	targets	target	NNS
cord-006229-7yoilsho	1470	19	in	in	IN
cord-006229-7yoilsho	1470	20	modern	modern	JJ
cord-006229-7yoilsho	1470	21	medicine	medicine	NN
cord-006229-7yoilsho	1470	22	.	.	.
cord-006229-7yoilsho	1471	1	However	however	RB
cord-006229-7yoilsho	1471	2	,	,	,
cord-006229-7yoilsho	1471	3	despite	despite	IN
cord-006229-7yoilsho	1471	4	their	-PRON-	PRP$
cord-006229-7yoilsho	1471	5	clinical	clinical	JJ
cord-006229-7yoilsho	1471	6	importance	importance	NN
cord-006229-7yoilsho	1471	7	,	,	,
cord-006229-7yoilsho	1471	8	fundamental	fundamental	JJ
cord-006229-7yoilsho	1471	9	properties	property	NNS
cord-006229-7yoilsho	1471	10	of	of	IN
cord-006229-7yoilsho	1471	11	these	these	DT
cord-006229-7yoilsho	1471	12	receptors	receptor	NNS
cord-006229-7yoilsho	1471	13	remain	remain	VBP
cord-006229-7yoilsho	1471	14	unknown	unknown	JJ
cord-006229-7yoilsho	1471	15	.	.	.
cord-006229-7yoilsho	1472	1	In	in	IN
cord-006229-7yoilsho	1472	2	particular	particular	JJ
cord-006229-7yoilsho	1472	3	,	,	,
cord-006229-7yoilsho	1472	4	regulation	regulation	NN
cord-006229-7yoilsho	1472	5	of	of	IN
cord-006229-7yoilsho	1472	6	the	the	DT
cord-006229-7yoilsho	1472	7	major	major	JJ
cord-006229-7yoilsho	1472	8	second	second	JJ
cord-006229-7yoilsho	1472	9	messenger	messenger	NN
cord-006229-7yoilsho	1472	10	cAMP	camp	NN
cord-006229-7yoilsho	1472	11	by	by	IN
cord-006229-7yoilsho	1472	12	G	G	NNP
cord-006229-7yoilsho	1472	13	s	s	NNP
cord-006229-7yoilsho	1472	14	-and	-and	CC
cord-006229-7yoilsho	1472	15	G	g	NN
cord-006229-7yoilsho	1473	1	i/	i/	NNP
cord-006229-7yoilsho	1474	1	o	o	UH
cord-006229-7yoilsho	1474	2	-protein	-protein	RB
cord-006229-7yoilsho	1474	3	coupled	coupled	JJ
cord-006229-7yoilsho	1474	4	receptors	receptor	NNS
cord-006229-7yoilsho	1474	5	is	be	VBZ
cord-006229-7yoilsho	1474	6	of	of	IN
cord-006229-7yoilsho	1474	7	special	special	JJ
cord-006229-7yoilsho	1474	8	interest	interest	NN
cord-006229-7yoilsho	1474	9	.	.	.
cord-006229-7yoilsho	1475	1	The	the	DT
cord-006229-7yoilsho	1475	2	classical	classical	JJ
cord-006229-7yoilsho	1475	3	biochemical	biochemical	JJ
cord-006229-7yoilsho	1475	4	method	method	NN
cord-006229-7yoilsho	1475	5	to	to	TO
cord-006229-7yoilsho	1475	6	detect	detect	VB
cord-006229-7yoilsho	1475	7	receptor	receptor	NN
cord-006229-7yoilsho	1475	8	-	-	HYPH
cord-006229-7yoilsho	1475	9	mediated	mediate	VBN
cord-006229-7yoilsho	1475	10	cAMP	camp	NN
cord-006229-7yoilsho	1475	11	level	level	NN
cord-006229-7yoilsho	1475	12	changes	change	NNS
cord-006229-7yoilsho	1475	13	uses	use	VBZ
cord-006229-7yoilsho	1475	14	pre	pre	JJ
cord-006229-7yoilsho	1475	15	-	-	JJ
cord-006229-7yoilsho	1475	16	labeling	labeling	NN
cord-006229-7yoilsho	1475	17	with	with	IN
cord-006229-7yoilsho	1475	18	3	3	CD
cord-006229-7yoilsho	1475	19	H	h	NN
cord-006229-7yoilsho	1475	20	-	-	HYPH
cord-006229-7yoilsho	1475	21	Adenine	adenine	NN
cord-006229-7yoilsho	1475	22	and	and	CC
cord-006229-7yoilsho	1475	23	calculation	calculation	NN
cord-006229-7yoilsho	1475	24	of	of	IN
cord-006229-7yoilsho	1475	25	the	the	DT
cord-006229-7yoilsho	1475	26	conversion	conversion	NN
cord-006229-7yoilsho	1475	27	rate	rate	NN
cord-006229-7yoilsho	1475	28	to	to	IN
cord-006229-7yoilsho	1475	29	3	3	CD
cord-006229-7yoilsho	1475	30	H	h	NN
cord-006229-7yoilsho	1475	31	-	-	HYPH
cord-006229-7yoilsho	1475	32	cAMP	camp	NN
cord-006229-7yoilsho	1475	33	.	.	.
cord-006229-7yoilsho	1476	1	Although	although	IN
cord-006229-7yoilsho	1476	2	,	,	,
cord-006229-7yoilsho	1476	3	this	this	DT
cord-006229-7yoilsho	1476	4	multi	multi	JJ
cord-006229-7yoilsho	1476	5	-	-	JJ
cord-006229-7yoilsho	1476	6	cellular	cellular	JJ
cord-006229-7yoilsho	1476	7	method	method	NN
cord-006229-7yoilsho	1476	8	is	be	VBZ
cord-006229-7yoilsho	1476	9	highly	highly	RB
cord-006229-7yoilsho	1476	10	sensitive	sensitive	JJ
cord-006229-7yoilsho	1476	11	and	and	CC
cord-006229-7yoilsho	1476	12	reproducible	reproducible	JJ
cord-006229-7yoilsho	1476	13	,	,	,
cord-006229-7yoilsho	1476	14	it	-PRON-	PRP
cord-006229-7yoilsho	1476	15	lacks	lack	VBZ
cord-006229-7yoilsho	1476	16	time	time	NN
cord-006229-7yoilsho	1476	17	resolved	resolve	VBN
cord-006229-7yoilsho	1476	18	and	and	CC
cord-006229-7yoilsho	1476	19	spacial	spacial	JJ
cord-006229-7yoilsho	1476	20	assessment	assessment	NN
cord-006229-7yoilsho	1476	21	of	of	IN
cord-006229-7yoilsho	1476	22	cAMP	camp	NN
cord-006229-7yoilsho	1476	23	formation	formation	NN
cord-006229-7yoilsho	1476	24	in	in	IN
cord-006229-7yoilsho	1476	25	single	single	JJ
cord-006229-7yoilsho	1476	26	living	living	NN
cord-006229-7yoilsho	1476	27	cells	cell	NNS
cord-006229-7yoilsho	1476	28	.	.	.
cord-006229-7yoilsho	1477	1	To	to	TO
cord-006229-7yoilsho	1477	2	measure	measure	VB
cord-006229-7yoilsho	1477	3	G	G	NNP
cord-006229-7yoilsho	1477	4	s	s	POS
cord-006229-7yoilsho	1477	5	-protein	-protein	NN
cord-006229-7yoilsho	1477	6	induced	induce	VBN
cord-006229-7yoilsho	1477	7	increases	increase	NNS
cord-006229-7yoilsho	1477	8	of	of	IN
cord-006229-7yoilsho	1477	9	intracellular	intracellular	JJ
cord-006229-7yoilsho	1477	10	cAMP	camp	NN
cord-006229-7yoilsho	1477	11	levels	level	NNS
cord-006229-7yoilsho	1477	12	in	in	IN
cord-006229-7yoilsho	1477	13	single	single	JJ
cord-006229-7yoilsho	1477	14	living	living	NN
cord-006229-7yoilsho	1477	15	cells	cell	NNS
cord-006229-7yoilsho	1477	16	in	in	IN
cord-006229-7yoilsho	1477	17	a	a	DT
cord-006229-7yoilsho	1477	18	time	time	NN
cord-006229-7yoilsho	1477	19	resolved	resolve	VBN
cord-006229-7yoilsho	1477	20	manner	manner	NN
cord-006229-7yoilsho	1477	21	,	,	,
cord-006229-7yoilsho	1477	22	the	the	DT
cord-006229-7yoilsho	1477	23	FRET	fret	NN
cord-006229-7yoilsho	1477	24	-	-	HYPH
cord-006229-7yoilsho	1477	25	based	base	VBN
cord-006229-7yoilsho	1477	26	cAMP	camp	NN
cord-006229-7yoilsho	1477	27	-	-	HYPH
cord-006229-7yoilsho	1477	28	sensor	sensor	NN
cord-006229-7yoilsho	1477	29	Epac	Epac	NNP
cord-006229-7yoilsho	1477	30	is	be	VBZ
cord-006229-7yoilsho	1477	31	commonly	commonly	RB
cord-006229-7yoilsho	1477	32	used	use	VBN
cord-006229-7yoilsho	1477	33	.	.	.
cord-006229-7yoilsho	1478	1	However	however	RB
cord-006229-7yoilsho	1478	2	,	,	,
cord-006229-7yoilsho	1478	3	it	-PRON-	PRP
cord-006229-7yoilsho	1478	4	was	be	VBD
cord-006229-7yoilsho	1478	5	unknown	unknown	JJ
cord-006229-7yoilsho	1478	6	whether	whether	IN
cord-006229-7yoilsho	1478	7	this	this	DT
cord-006229-7yoilsho	1478	8	sensor	sensor	NN
cord-006229-7yoilsho	1478	9	might	may	MD
cord-006229-7yoilsho	1478	10	be	be	VB
cord-006229-7yoilsho	1478	11	suitable	suitable	JJ
cord-006229-7yoilsho	1478	12	to	to	TO
cord-006229-7yoilsho	1478	13	detect	detect	VB
cord-006229-7yoilsho	1478	14	G	g	NN
cord-006229-7yoilsho	1479	1	i/	i/	NNP
cord-006229-7yoilsho	1480	1	o	o	UH
cord-006229-7yoilsho	1480	2	-protein	-protein	RB
cord-006229-7yoilsho	1480	3	mediated	mediate	VBN
cord-006229-7yoilsho	1480	4	decreases	decrease	NNS
cord-006229-7yoilsho	1480	5	of	of	IN
cord-006229-7yoilsho	1480	6	intracellular	intracellular	JJ
cord-006229-7yoilsho	1480	7	cAMP	camp	NN
cord-006229-7yoilsho	1480	8	levels	level	NNS
cord-006229-7yoilsho	1480	9	as	as	RB
cord-006229-7yoilsho	1480	10	well	well	RB
cord-006229-7yoilsho	1480	11	.	.	.
cord-006229-7yoilsho	1481	1	In	in	IN
cord-006229-7yoilsho	1481	2	this	this	DT
cord-006229-7yoilsho	1481	3	study	study	NN
cord-006229-7yoilsho	1481	4	,	,	,
cord-006229-7yoilsho	1481	5	we	-PRON-	PRP
cord-006229-7yoilsho	1481	6	show	show	VBP
cord-006229-7yoilsho	1481	7	that	that	IN
cord-006229-7yoilsho	1481	8	FRET	fret	NN
cord-006229-7yoilsho	1481	9	-	-	HYPH
cord-006229-7yoilsho	1481	10	based	base	VBN
cord-006229-7yoilsho	1481	11	cAMP	camp	NN
cord-006229-7yoilsho	1481	12	sensors	sensor	NNS
cord-006229-7yoilsho	1481	13	can	can	MD
cord-006229-7yoilsho	1481	14	be	be	VB
cord-006229-7yoilsho	1481	15	deployed	deploy	VBN
cord-006229-7yoilsho	1481	16	to	to	TO
cord-006229-7yoilsho	1481	17	reliably	reliably	RB
cord-006229-7yoilsho	1481	18	monitor	monitor	VB
cord-006229-7yoilsho	1481	19	G	G	NNP
cord-006229-7yoilsho	1481	20	i	i	NN
cord-006229-7yoilsho	1481	21	/	/	SYM
cord-006229-7yoilsho	1481	22	o	o	NN
cord-006229-7yoilsho	1481	23	-protein	-protein	RB
cord-006229-7yoilsho	1481	24	mediated	mediate	VBN
cord-006229-7yoilsho	1481	25	cAMP	camp	NN
cord-006229-7yoilsho	1481	26	level	level	NN
cord-006229-7yoilsho	1481	27	decreases	decrease	NNS
cord-006229-7yoilsho	1481	28	.	.	.
cord-006229-7yoilsho	1482	1	FRET	fret	NN
cord-006229-7yoilsho	1482	2	experiments	experiment	NNS
cord-006229-7yoilsho	1482	3	with	with	IN
cord-006229-7yoilsho	1482	4	adrenergic	adrenergic	NN
cord-006229-7yoilsho	1482	5	α	α	NN
cord-006229-7yoilsho	1482	6	2A	2a	CD
cord-006229-7yoilsho	1482	7	or	or	CC
cord-006229-7yoilsho	1482	8	µ	µ	NN
cord-006229-7yoilsho	1482	9	1	1	CD
cord-006229-7yoilsho	1482	10	opioid	opioid	NN
cord-006229-7yoilsho	1482	11	receptors	receptor	NNS
cord-006229-7yoilsho	1482	12	in	in	IN
cord-006229-7yoilsho	1482	13	combination	combination	NN
cord-006229-7yoilsho	1482	14	with	with	IN
cord-006229-7yoilsho	1482	15	different	different	JJ
cord-006229-7yoilsho	1482	16	FRET	fret	NN
cord-006229-7yoilsho	1482	17	-	-	HYPH
cord-006229-7yoilsho	1482	18	based	base	VBN
cord-006229-7yoilsho	1482	19	cAMP	camp	NN
cord-006229-7yoilsho	1482	20	sensors	sensor	NNS
cord-006229-7yoilsho	1482	21	showed	show	VBD
cord-006229-7yoilsho	1482	22	a	a	DT
cord-006229-7yoilsho	1482	23	notable	notable	JJ
cord-006229-7yoilsho	1482	24	reduction	reduction	NN
cord-006229-7yoilsho	1482	25	of	of	IN
cord-006229-7yoilsho	1482	26	intracellular	intracellular	JJ
cord-006229-7yoilsho	1482	27	cAMP	camp	NN
cord-006229-7yoilsho	1482	28	levels	level	NNS
cord-006229-7yoilsho	1482	29	upon	upon	IN
cord-006229-7yoilsho	1482	30	receptor	receptor	NN
cord-006229-7yoilsho	1482	31	activation	activation	NN
cord-006229-7yoilsho	1482	32	which	which	WDT
cord-006229-7yoilsho	1482	33	could	could	MD
cord-006229-7yoilsho	1482	34	be	be	VB
cord-006229-7yoilsho	1482	35	significantly	significantly	RB
cord-006229-7yoilsho	1482	36	reduced	reduce	VBN
cord-006229-7yoilsho	1482	37	by	by	IN
cord-006229-7yoilsho	1482	38	selective	selective	JJ
cord-006229-7yoilsho	1482	39	receptor	receptor	NN
cord-006229-7yoilsho	1482	40	antagonists	antagonist	NNS
cord-006229-7yoilsho	1482	41	.	.	.
cord-006229-7yoilsho	1483	1	Of	of	IN
cord-006229-7yoilsho	1483	2	note	note	NN
cord-006229-7yoilsho	1483	3	,	,	,
cord-006229-7yoilsho	1483	4	HEK293	HEK293	NNP
cord-006229-7yoilsho	1483	5	cells	cell	NNS
cord-006229-7yoilsho	1483	6	had	have	VBD
cord-006229-7yoilsho	1483	7	to	to	TO
cord-006229-7yoilsho	1483	8	be	be	VB
cord-006229-7yoilsho	1483	9	pre	pre	VBN
cord-006229-7yoilsho	1483	10	-	-	VBN
cord-006229-7yoilsho	1483	11	incubated	incubate	VBN
cord-006229-7yoilsho	1483	12	with	with	IN
cord-006229-7yoilsho	1483	13	forskolin	forskolin	NN
cord-006229-7yoilsho	1483	14	in	in	IN
cord-006229-7yoilsho	1483	15	submaximal	submaximal	JJ
cord-006229-7yoilsho	1483	16	concentration	concentration	NN
cord-006229-7yoilsho	1483	17	to	to	TO
cord-006229-7yoilsho	1483	18	increase	increase	VB
cord-006229-7yoilsho	1483	19	basal	basal	NN
cord-006229-7yoilsho	1483	20	cAMP	camp	NN
cord-006229-7yoilsho	1483	21	levels	level	NNS
cord-006229-7yoilsho	1483	22	.	.	.
cord-006229-7yoilsho	1484	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	1484	2	findings	finding	NNS
cord-006229-7yoilsho	1484	3	suggest	suggest	VBP
cord-006229-7yoilsho	1484	4	that	that	IN
cord-006229-7yoilsho	1484	5	FRET	fret	NN
cord-006229-7yoilsho	1484	6	based	base	VBN
cord-006229-7yoilsho	1484	7	Epac	Epac	NNP
cord-006229-7yoilsho	1484	8	sensors	sensor	NNS
cord-006229-7yoilsho	1484	9	are	be	VBP
cord-006229-7yoilsho	1484	10	suitable	suitable	JJ
cord-006229-7yoilsho	1484	11	to	to	TO
cord-006229-7yoilsho	1484	12	detect	detect	VB
cord-006229-7yoilsho	1484	13	G	G	NNP
cord-006229-7yoilsho	1484	14	i	i	NN
cord-006229-7yoilsho	1484	15	/	/	SYM
cord-006229-7yoilsho	1484	16	o	o	NN
cord-006229-7yoilsho	1484	17	-protein	-protein	NN
cord-006229-7yoilsho	1484	18	activation	activation	NN
cord-006229-7yoilsho	1484	19	similar	similar	JJ
cord-006229-7yoilsho	1484	20	to	to	IN
cord-006229-7yoilsho	1484	21	electrophysiological	electrophysiological	JJ
cord-006229-7yoilsho	1484	22	whole	whole	JJ
cord-006229-7yoilsho	1484	23	-	-	HYPH
cord-006229-7yoilsho	1484	24	cell	cell	NN
cord-006229-7yoilsho	1484	25	measurements	measurement	NNS
cord-006229-7yoilsho	1484	26	with	with	IN
cord-006229-7yoilsho	1484	27	G	g	NN
cord-006229-7yoilsho	1484	28	i	i	NN
cord-006229-7yoilsho	1484	29	/	/	SYM
cord-006229-7yoilsho	1484	30	o	o	NN
cord-006229-7yoilsho	1484	31	-protein	-protein	CC
cord-006229-7yoilsho	1484	32	coupled	coupled	JJ
cord-006229-7yoilsho	1484	33	receptors	receptor	NNS
cord-006229-7yoilsho	1484	34	and	and	CC
cord-006229-7yoilsho	1485	1	TRPC5	TRPC5	NNP
cord-006229-7yoilsho	1485	2	or	or	CC
cord-006229-7yoilsho	1485	3	heteromeric	heteromeric	NNP
cord-006229-7yoilsho	1485	4	Kir3.1	Kir3.1	NNP
cord-006229-7yoilsho	1485	5	/	/	SYM
cord-006229-7yoilsho	1485	6	Kir3.2	Kir3.2	NNP
cord-006229-7yoilsho	1485	7	or	or	CC
cord-006229-7yoilsho	1485	8	Kir3.1	Kir3.1	NNP
cord-006229-7yoilsho	1485	9	/	/	SYM
cord-006229-7yoilsho	1485	10	Kir3.4	kir3.4	JJ
cord-006229-7yoilsho	1485	11	channels	channel	NNS
cord-006229-7yoilsho	1485	12	coexpressing	coexpresse	VBG
cord-006229-7yoilsho	1485	13	cells	cell	NNS
cord-006229-7yoilsho	1485	14	.	.	.
cord-006229-7yoilsho	1486	1	Hereby	hereby	RB
cord-006229-7yoilsho	1486	2	,	,	,
cord-006229-7yoilsho	1486	3	agonist	agonist	NN
cord-006229-7yoilsho	1486	4	stimulations	stimulation	NNS
cord-006229-7yoilsho	1486	5	caused	cause	VBD
cord-006229-7yoilsho	1486	6	current	current	JJ
cord-006229-7yoilsho	1486	7	increases	increase	NNS
cord-006229-7yoilsho	1486	8	with	with	IN
cord-006229-7yoilsho	1486	9	characteristic	characteristic	JJ
cord-006229-7yoilsho	1486	10	current	current	JJ
cord-006229-7yoilsho	1486	11	-	-	HYPH
cord-006229-7yoilsho	1486	12	voltage	voltage	NN
cord-006229-7yoilsho	1486	13	relationships	relationship	NNS
cord-006229-7yoilsho	1486	14	.	.	.
cord-006229-7yoilsho	1487	1	Altogether	altogether	RB
cord-006229-7yoilsho	1487	2	,	,	,
cord-006229-7yoilsho	1487	3	our	-PRON-	PRP$
cord-006229-7yoilsho	1487	4	findings	finding	NNS
cord-006229-7yoilsho	1487	5	indicate	indicate	VBP
cord-006229-7yoilsho	1487	6	that	that	IN
cord-006229-7yoilsho	1487	7	both	both	CC
cord-006229-7yoilsho	1487	8	optical	optical	JJ
cord-006229-7yoilsho	1487	9	and	and	CC
cord-006229-7yoilsho	1487	10	electrophysiological	electrophysiological	JJ
cord-006229-7yoilsho	1487	11	approaches	approach	NNS
cord-006229-7yoilsho	1487	12	allow	allow	VBP
cord-006229-7yoilsho	1487	13	time	time	NN
cord-006229-7yoilsho	1487	14	resolved	resolve	VBD
cord-006229-7yoilsho	1487	15	detection	detection	NN
cord-006229-7yoilsho	1487	16	and	and	CC
cord-006229-7yoilsho	1487	17	characterization	characterization	NN
cord-006229-7yoilsho	1487	18	of	of	IN
cord-006229-7yoilsho	1487	19	G	g	NN
cord-006229-7yoilsho	1487	20	i	i	NN
cord-006229-7yoilsho	1487	21	/	/	SYM
cord-006229-7yoilsho	1487	22	o	o	NN
cord-006229-7yoilsho	1487	23	-protein	-protein	CC
cord-006229-7yoilsho	1487	24	coupled	couple	VBN
cord-006229-7yoilsho	1487	25	receptor	receptor	NN
cord-006229-7yoilsho	1487	26	activation	activation	NN
cord-006229-7yoilsho	1487	27	in	in	IN
cord-006229-7yoilsho	1487	28	single	single	JJ
cord-006229-7yoilsho	1487	29	living	living	NN
cord-006229-7yoilsho	1487	30	cells	cell	NNS
cord-006229-7yoilsho	1487	31	.	.	.
cord-006229-7yoilsho	1488	1	Histamine	histamine	NN
cord-006229-7yoilsho	1488	2	can	can	MD
cord-006229-7yoilsho	1488	3	exert	exert	VB
cord-006229-7yoilsho	1488	4	positive	positive	JJ
cord-006229-7yoilsho	1488	5	inotropic	inotropic	NNP
cord-006229-7yoilsho	1488	6	and	and	CC
cord-006229-7yoilsho	1488	7	chronotropic	chronotropic	JJ
cord-006229-7yoilsho	1488	8	effects	effect	NNS
cord-006229-7yoilsho	1488	9	in	in	IN
cord-006229-7yoilsho	1488	10	humans	human	NNS
cord-006229-7yoilsho	1488	11	via	via	IN
cord-006229-7yoilsho	1488	12	histamine	histamine	NN
cord-006229-7yoilsho	1488	13	H	H	NNP
cord-006229-7yoilsho	1488	14	2	2	CD
cord-006229-7yoilsho	1488	15	-receptors	-receptor	NNS
cord-006229-7yoilsho	1488	16	.	.	.
cord-006229-7yoilsho	1489	1	We	-PRON-	PRP
cord-006229-7yoilsho	1489	2	have	have	VBP
cord-006229-7yoilsho	1489	3	generated	generate	VBN
cord-006229-7yoilsho	1489	4	and	and	CC
cord-006229-7yoilsho	1489	5	partially	partially	RB
cord-006229-7yoilsho	1489	6	characterized	characterize	VBN
cord-006229-7yoilsho	1489	7	transgenic	transgenic	JJ
cord-006229-7yoilsho	1489	8	mice	mouse	NNS
cord-006229-7yoilsho	1489	9	(	(	-LRB-
cord-006229-7yoilsho	1489	10	TG	TG	NNP
cord-006229-7yoilsho	1489	11	)	)	-RRB-
cord-006229-7yoilsho	1489	12	which	which	WDT
cord-006229-7yoilsho	1489	13	overexpress	overexpress	VBP
cord-006229-7yoilsho	1489	14	the	the	DT
cord-006229-7yoilsho	1489	15	human	human	JJ
cord-006229-7yoilsho	1489	16	histamine	histamine	NN
cord-006229-7yoilsho	1489	17	H	H	NNP
cord-006229-7yoilsho	1489	18	2	2	CD
cord-006229-7yoilsho	1489	19	-receptor	-receptor	NN
cord-006229-7yoilsho	1489	20	specifically	specifically	RB
cord-006229-7yoilsho	1489	21	in	in	IN
cord-006229-7yoilsho	1489	22	cardiomyocytes	cardiomyocyte	NNS
cord-006229-7yoilsho	1489	23	via	via	IN
cord-006229-7yoilsho	1489	24	the	the	DT
cord-006229-7yoilsho	1489	25	α	α	NN
cord-006229-7yoilsho	1489	26	-	-	HYPH
cord-006229-7yoilsho	1489	27	myosin	myosin	NN
cord-006229-7yoilsho	1489	28	heavy	heavy	JJ
cord-006229-7yoilsho	1489	29	chain	chain	NN
cord-006229-7yoilsho	1489	30	promoter	promoter	NN
cord-006229-7yoilsho	1489	31	.	.	.
cord-006229-7yoilsho	1490	1	In	in	IN
cord-006229-7yoilsho	1490	2	these	these	DT
cord-006229-7yoilsho	1490	3	mice	mouse	NNS
cord-006229-7yoilsho	1490	4	,	,	,
cord-006229-7yoilsho	1490	5	but	but	CC
cord-006229-7yoilsho	1490	6	not	not	RB
cord-006229-7yoilsho	1490	7	in	in	IN
cord-006229-7yoilsho	1490	8	wild	wild	JJ
cord-006229-7yoilsho	1490	9	type	type	NN
cord-006229-7yoilsho	1490	10	mice	mouse	NNS
cord-006229-7yoilsho	1490	11	(	(	-LRB-
cord-006229-7yoilsho	1490	12	WT	WT	NNP
cord-006229-7yoilsho	1490	13	)	)	-RRB-
cord-006229-7yoilsho	1490	14	,	,	,
cord-006229-7yoilsho	1490	15	histamine	histamine	NN
cord-006229-7yoilsho	1490	16	increased	increase	VBN
cord-006229-7yoilsho	1490	17	heart	heart	NN
cord-006229-7yoilsho	1490	18	rate	rate	NN
cord-006229-7yoilsho	1490	19	and	and	CC
cord-006229-7yoilsho	1490	20	ejection	ejection	NN
cord-006229-7yoilsho	1490	21	fraction	fraction	NN
cord-006229-7yoilsho	1490	22	(	(	-LRB-
cord-006229-7yoilsho	1490	23	EF	EF	NNP
cord-006229-7yoilsho	1490	24	)	)	-RRB-
cord-006229-7yoilsho	1490	25	measured	measure	VBN
cord-006229-7yoilsho	1490	26	in	in	IN
cord-006229-7yoilsho	1490	27	vivo	vivo	NN
cord-006229-7yoilsho	1490	28	by	by	IN
cord-006229-7yoilsho	1490	29	echocardiography	echocardiography	NN
cord-006229-7yoilsho	1490	30	under	under	IN
cord-006229-7yoilsho	1490	31	isoflurane	isoflurane	JJ
cord-006229-7yoilsho	1490	32	anesthesia	anesthesia	NNP
cord-006229-7yoilsho	1490	33	.	.	.
cord-006229-7yoilsho	1491	1	To	to	TO
cord-006229-7yoilsho	1491	2	investigate	investigate	VB
cord-006229-7yoilsho	1491	3	some	some	DT
cord-006229-7yoilsho	1491	4	aspects	aspect	NNS
cord-006229-7yoilsho	1491	5	of	of	IN
cord-006229-7yoilsho	1491	6	the	the	DT
cord-006229-7yoilsho	1491	7	signaling	signal	VBG
cord-006229-7yoilsho	1491	8	pathway	pathway	NN
cord-006229-7yoilsho	1491	9	in	in	IN
cord-006229-7yoilsho	1491	10	these	these	DT
cord-006229-7yoilsho	1491	11	mice	mouse	NNS
cord-006229-7yoilsho	1491	12	,	,	,
cord-006229-7yoilsho	1491	13	we	-PRON-	PRP
cord-006229-7yoilsho	1491	14	crossed	cross	VBD
cord-006229-7yoilsho	1491	15	the	the	DT
cord-006229-7yoilsho	1491	16	TG	TG	NNP
cord-006229-7yoilsho	1491	17	mice	mouse	NNS
cord-006229-7yoilsho	1491	18	with	with	IN
cord-006229-7yoilsho	1491	19	PP2A	PP2A	NNS
cord-006229-7yoilsho	1491	20	mice	mouse	NNS
cord-006229-7yoilsho	1491	21	leading	lead	VBG
cord-006229-7yoilsho	1491	22	to	to	IN
cord-006229-7yoilsho	1491	23	double	double	JJ
cord-006229-7yoilsho	1491	24	transgenic	transgenic	JJ
cord-006229-7yoilsho	1491	25	mice	mouse	NNS
cord-006229-7yoilsho	1491	26	(	(	-LRB-
cord-006229-7yoilsho	1491	27	H	h	NN
cord-006229-7yoilsho	1491	28	2	2	CD
cord-006229-7yoilsho	1491	29	xPP2A	xpp2a	CD
cord-006229-7yoilsho	1491	30	=	=	SYM
cord-006229-7yoilsho	1491	31	DT	DT	NNP
cord-006229-7yoilsho	1491	32	)	)	-RRB-
cord-006229-7yoilsho	1491	33	.	.	.
cord-006229-7yoilsho	1492	1	PP2A	PP2A	NNS
cord-006229-7yoilsho	1493	1	mice	mouse	NNS
cord-006229-7yoilsho	1493	2	(	(	-LRB-
cord-006229-7yoilsho	1493	3	J	J	NNP
cord-006229-7yoilsho	1493	4	Biol	Biol	NNP
cord-006229-7yoilsho	1493	5	Chem	Chem	NNP
cord-006229-7yoilsho	1493	6	2004	2004	CD
cord-006229-7yoilsho	1493	7	;	;	:
cord-006229-7yoilsho	1493	8	279:40827	279:40827	NNP
cord-006229-7yoilsho	1493	9	)	)	-RRB-
cord-006229-7yoilsho	1493	10	overexpress	overexpress	VBP
cord-006229-7yoilsho	1493	11	the	the	DT
cord-006229-7yoilsho	1493	12	catalytic	catalytic	JJ
cord-006229-7yoilsho	1493	13	subunit	subunit	NN
cord-006229-7yoilsho	1493	14	of	of	IN
cord-006229-7yoilsho	1493	15	protein	protein	NN
cord-006229-7yoilsho	1493	16	phosphatase	phosphatase	NN
cord-006229-7yoilsho	1493	17	2A	2a	CD
cord-006229-7yoilsho	1494	1	(	(	-LRB-
cord-006229-7yoilsho	1494	2	PP2A	pp2a	NN
cord-006229-7yoilsho	1494	3	)	)	-RRB-
cord-006229-7yoilsho	1495	1	in	in	IN
cord-006229-7yoilsho	1495	2	cardiac	cardiac	JJ
cord-006229-7yoilsho	1495	3	myocytes	myocyte	NNS
cord-006229-7yoilsho	1495	4	and	and	CC
cord-006229-7yoilsho	1495	5	develop	develop	VB
cord-006229-7yoilsho	1495	6	a	a	DT
cord-006229-7yoilsho	1495	7	cardiac	cardiac	JJ
cord-006229-7yoilsho	1495	8	hypertrophy	hypertrophy	NN
cord-006229-7yoilsho	1495	9	.	.	.
cord-006229-7yoilsho	1496	1	At	at	IN
cord-006229-7yoilsho	1496	2	an	an	DT
cord-006229-7yoilsho	1496	3	age	age	NN
cord-006229-7yoilsho	1496	4	of	of	IN
cord-006229-7yoilsho	1496	5	about	about	RB
cord-006229-7yoilsho	1496	6	240	240	CD
cord-006229-7yoilsho	1496	7	days	day	NNS
cord-006229-7yoilsho	1496	8	we	-PRON-	PRP
cord-006229-7yoilsho	1496	9	noted	note	VBD
cord-006229-7yoilsho	1496	10	reduced	reduce	VBN
cord-006229-7yoilsho	1496	11	EF	EF	NNP
cord-006229-7yoilsho	1496	12	in	in	IN
cord-006229-7yoilsho	1496	13	PP2A	PP2A	NNS
cord-006229-7yoilsho	1496	14	(	(	-LRB-
cord-006229-7yoilsho	1496	15	33.1	33.1	CD
cord-006229-7yoilsho	1496	16	±	±	CD
cord-006229-7yoilsho	1496	17	3.5	3.5	CD
cord-006229-7yoilsho	1496	18	%	%	NN
cord-006229-7yoilsho	1496	19	,	,	,
cord-006229-7yoilsho	1496	20	n=16	n=16	NNP
cord-006229-7yoilsho	1496	21	)	)	-RRB-
cord-006229-7yoilsho	1496	22	compared	compare	VBN
cord-006229-7yoilsho	1496	23	to	to	IN
cord-006229-7yoilsho	1496	24	WT	WT	NNP
cord-006229-7yoilsho	1496	25	(	(	-LRB-
cord-006229-7yoilsho	1496	26	54.4	54.4	CD
cord-006229-7yoilsho	1496	27	±	±	CD
cord-006229-7yoilsho	1496	28	4.5	4.5	CD
cord-006229-7yoilsho	1496	29	%	%	NN
cord-006229-7yoilsho	1496	30	,	,	,
cord-006229-7yoilsho	1496	31	n=10	n=10	NNP
cord-006229-7yoilsho	1496	32	)	)	-RRB-
cord-006229-7yoilsho	1496	33	and	and	CC
cord-006229-7yoilsho	1496	34	TG	TG	NNP
cord-006229-7yoilsho	1496	35	(	(	-LRB-
cord-006229-7yoilsho	1496	36	59.8	59.8	CD
cord-006229-7yoilsho	1496	37	±	±	CD
cord-006229-7yoilsho	1496	38	2.9	2.9	CD
cord-006229-7yoilsho	1496	39	%	%	NN
cord-006229-7yoilsho	1496	40	,	,	,
cord-006229-7yoilsho	1496	41	n=10	n=10	NNP
cord-006229-7yoilsho	1496	42	)	)	-RRB-
cord-006229-7yoilsho	1496	43	.	.	.
cord-006229-7yoilsho	1497	1	Interestingly	interestingly	RB
cord-006229-7yoilsho	1497	2	,	,	,
cord-006229-7yoilsho	1497	3	in	in	IN
cord-006229-7yoilsho	1497	4	DT	DT	NNP
cord-006229-7yoilsho	1497	5	the	the	DT
cord-006229-7yoilsho	1497	6	EF	ef	NN
cord-006229-7yoilsho	1497	7	(	(	-LRB-
cord-006229-7yoilsho	1497	8	43.9	43.9	CD
cord-006229-7yoilsho	1497	9	±	±	CD
cord-006229-7yoilsho	1497	10	4.9	4.9	CD
cord-006229-7yoilsho	1497	11	%	%	NN
cord-006229-7yoilsho	1497	12	,	,	,
cord-006229-7yoilsho	1497	13	n=11	n=11	FW
cord-006229-7yoilsho	1497	14	)	)	-RRB-
cord-006229-7yoilsho	1497	15	was	be	VBD
cord-006229-7yoilsho	1497	16	higher	high	JJR
cord-006229-7yoilsho	1497	17	than	than	IN
cord-006229-7yoilsho	1497	18	in	in	IN
cord-006229-7yoilsho	1497	19	PP2A	PP2A	NNS
cord-006229-7yoilsho	1497	20	at	at	IN
cord-006229-7yoilsho	1497	21	similar	similar	JJ
cord-006229-7yoilsho	1497	22	heart	heart	NN
cord-006229-7yoilsho	1497	23	rates	rate	NNS
cord-006229-7yoilsho	1497	24	.	.	.
cord-006229-7yoilsho	1498	1	E´/A	E´/A	NNP
cord-006229-7yoilsho	1498	2	´	´	CD
cord-006229-7yoilsho	1498	3	was	be	VBD
cord-006229-7yoilsho	1498	4	elevated	elevate	VBN
cord-006229-7yoilsho	1498	5	in	in	IN
cord-006229-7yoilsho	1498	6	DT	DT	NNP
cord-006229-7yoilsho	1498	7	compared	compare	VBN
cord-006229-7yoilsho	1498	8	to	to	IN
cord-006229-7yoilsho	1498	9	WT	WT	NNP
cord-006229-7yoilsho	1498	10	.	.	.
cord-006229-7yoilsho	1499	1	Relative	relative	JJ
cord-006229-7yoilsho	1499	2	heart	heart	NN
cord-006229-7yoilsho	1499	3	weights	weight	NNS
cord-006229-7yoilsho	1499	4	were	be	VBD
cord-006229-7yoilsho	1499	5	unchanged	unchanged	JJ
cord-006229-7yoilsho	1499	6	between	between	IN
cord-006229-7yoilsho	1499	7	these	these	DT
cord-006229-7yoilsho	1499	8	groups	group	NNS
cord-006229-7yoilsho	1499	9	.	.	.
cord-006229-7yoilsho	1500	1	In	in	IN
cord-006229-7yoilsho	1500	2	summary	summary	NN
cord-006229-7yoilsho	1500	3	,	,	,
cord-006229-7yoilsho	1500	4	we	-PRON-	PRP
cord-006229-7yoilsho	1500	5	demonstrated	demonstrate	VBD
cord-006229-7yoilsho	1500	6	that	that	IN
cord-006229-7yoilsho	1500	7	PP2A	PP2A	NNP
cord-006229-7yoilsho	1500	8	is	be	VBZ
cord-006229-7yoilsho	1500	9	involved	involve	VBN
cord-006229-7yoilsho	1500	10	in	in	IN
cord-006229-7yoilsho	1500	11	H	H	NNP
cord-006229-7yoilsho	1500	12	2	2	CD
cord-006229-7yoilsho	1500	13	-receptor	-receptor	NN
cord-006229-7yoilsho	1500	14	signaling	signal	VBG
cord-006229-7yoilsho	1501	1	and	and	CC
cord-006229-7yoilsho	1501	2	we	-PRON-	PRP
cord-006229-7yoilsho	1501	3	tentatively	tentatively	RB
cord-006229-7yoilsho	1501	4	conclude	conclude	VBP
cord-006229-7yoilsho	1501	5	that	that	IN
cord-006229-7yoilsho	1501	6	the	the	DT
cord-006229-7yoilsho	1501	7	H	H	NNP
cord-006229-7yoilsho	1501	8	2	2	CD
cord-006229-7yoilsho	1501	9	-receptor	-receptor	:
cord-006229-7yoilsho	1501	10	is	be	VBZ
cord-006229-7yoilsho	1501	11	able	able	JJ
cord-006229-7yoilsho	1501	12	to	to	TO
cord-006229-7yoilsho	1501	13	ameliorate	ameliorate	VB
cord-006229-7yoilsho	1501	14	systolic	systolic	JJ
cord-006229-7yoilsho	1501	15	but	but	CC
cord-006229-7yoilsho	1501	16	not	not	RB
cord-006229-7yoilsho	1501	17	diastolic	diastolic	JJ
cord-006229-7yoilsho	1501	18	cardiac	cardiac	JJ
cord-006229-7yoilsho	1501	19	function	function	NN
cord-006229-7yoilsho	1501	20	of	of	IN
cord-006229-7yoilsho	1501	21	PP2A	PP2A	NNS
cord-006229-7yoilsho	1501	22	mice	mouse	NNS
cord-006229-7yoilsho	1501	23	.	.	.
cord-006229-7yoilsho	1502	1	Serotonin	serotonin	NN
cord-006229-7yoilsho	1502	2	(	(	-LRB-
cord-006229-7yoilsho	1502	3	5-HT	5-ht	CD
cord-006229-7yoilsho	1502	4	)	)	-RRB-
cord-006229-7yoilsho	1502	5	can	can	MD
cord-006229-7yoilsho	1502	6	exert	exert	VB
cord-006229-7yoilsho	1502	7	positive	positive	JJ
cord-006229-7yoilsho	1502	8	inotropic	inotropic	NNP
cord-006229-7yoilsho	1502	9	and	and	CC
cord-006229-7yoilsho	1502	10	chronotropic	chronotropic	JJ
cord-006229-7yoilsho	1502	11	effects	effect	NNS
cord-006229-7yoilsho	1502	12	in	in	IN
cord-006229-7yoilsho	1502	13	humans	human	NNS
cord-006229-7yoilsho	1502	14	via	via	IN
cord-006229-7yoilsho	1502	15	5-HT	5-ht	CD
cord-006229-7yoilsho	1502	16	4	4	CD
cord-006229-7yoilsho	1502	17	-receptors	-receptor	NNS
cord-006229-7yoilsho	1502	18	.	.	.
cord-006229-7yoilsho	1503	1	We	-PRON-	PRP
cord-006229-7yoilsho	1503	2	have	have	VBP
cord-006229-7yoilsho	1503	3	generated	generate	VBN
cord-006229-7yoilsho	1503	4	transgenic	transgenic	JJ
cord-006229-7yoilsho	1503	5	mice	mouse	NNS
cord-006229-7yoilsho	1503	6	(	(	-LRB-
cord-006229-7yoilsho	1503	7	TG	TG	NNP
cord-006229-7yoilsho	1503	8	)	)	-RRB-
cord-006229-7yoilsho	1503	9	which	which	WDT
cord-006229-7yoilsho	1503	10	overexpress	overexpress	VBP
cord-006229-7yoilsho	1503	11	the	the	DT
cord-006229-7yoilsho	1503	12	human	human	JJ
cord-006229-7yoilsho	1503	13	5-HT	5-ht	CD
cord-006229-7yoilsho	1503	14	4	4	CD
cord-006229-7yoilsho	1503	15	-receptor	-receptor	VBG
cord-006229-7yoilsho	1503	16	selectively	selectively	RB
cord-006229-7yoilsho	1503	17	in	in	IN
cord-006229-7yoilsho	1503	18	cardiomyocytes	cardiomyocyte	NNS
cord-006229-7yoilsho	1503	19	via	via	IN
cord-006229-7yoilsho	1503	20	the	the	DT
cord-006229-7yoilsho	1503	21	α	α	NN
cord-006229-7yoilsho	1503	22	-	-	HYPH
cord-006229-7yoilsho	1503	23	myosin	myosin	NN
cord-006229-7yoilsho	1503	24	heavy	heavy	JJ
cord-006229-7yoilsho	1503	25	chain	chain	NN
cord-006229-7yoilsho	1503	26	promoter	promoter	NN
cord-006229-7yoilsho	1503	27	.	.	.
cord-006229-7yoilsho	1504	1	In	in	IN
cord-006229-7yoilsho	1504	2	these	these	DT
cord-006229-7yoilsho	1504	3	mice	mouse	NNS
cord-006229-7yoilsho	1504	4	,	,	,
cord-006229-7yoilsho	1504	5	but	but	CC
cord-006229-7yoilsho	1504	6	not	not	RB
cord-006229-7yoilsho	1504	7	in	in	IN
cord-006229-7yoilsho	1504	8	wild	wild	JJ
cord-006229-7yoilsho	1504	9	type	type	NN
cord-006229-7yoilsho	1504	10	mice	mouse	NNS
cord-006229-7yoilsho	1504	11	(	(	-LRB-
cord-006229-7yoilsho	1504	12	WT	WT	NNP
cord-006229-7yoilsho	1504	13	)	)	-RRB-
cord-006229-7yoilsho	1504	14	,	,	,
cord-006229-7yoilsho	1504	15	serotonin	serotonin	NN
cord-006229-7yoilsho	1504	16	induced	induce	VBN
cord-006229-7yoilsho	1504	17	increases	increase	VBZ
cord-006229-7yoilsho	1504	18	in	in	IN
cord-006229-7yoilsho	1504	19	heart	heart	NN
cord-006229-7yoilsho	1504	20	rate	rate	NN
cord-006229-7yoilsho	1504	21	and	and	CC
cord-006229-7yoilsho	1504	22	ejection	ejection	NN
cord-006229-7yoilsho	1504	23	fraction	fraction	NN
cord-006229-7yoilsho	1504	24	.	.	.
cord-006229-7yoilsho	1505	1	We	-PRON-	PRP
cord-006229-7yoilsho	1505	2	treated	treat	VBD
cord-006229-7yoilsho	1505	3	the	the	DT
cord-006229-7yoilsho	1505	4	mice	mice	NN
cord-006229-7yoilsho	1505	5	with	with	IN
cord-006229-7yoilsho	1505	6	30	30	CD
cord-006229-7yoilsho	1505	7	µg	µg	IN
cord-006229-7yoilsho	1505	8	LPS	LPS	NNP
cord-006229-7yoilsho	1505	9	(	(	-LRB-
cord-006229-7yoilsho	1505	10	lipopolysaccharide	lipopolysaccharide	NN
cord-006229-7yoilsho	1505	11	,	,	,
cord-006229-7yoilsho	1505	12	i.p	i.p	NNP
cord-006229-7yoilsho	1505	13	.	.	NNP
cord-006229-7yoilsho	1505	14	;	;	:
cord-006229-7yoilsho	1505	15	a	a	DT
cord-006229-7yoilsho	1505	16	standard	standard	JJ
cord-006229-7yoilsho	1505	17	model	model	NN
cord-006229-7yoilsho	1505	18	of	of	IN
cord-006229-7yoilsho	1505	19	sepsis	sepsis	NN
cord-006229-7yoilsho	1505	20	)	)	-RRB-
cord-006229-7yoilsho	1505	21	per	per	IN
cord-006229-7yoilsho	1505	22	g	g	NN
cord-006229-7yoilsho	1505	23	body	body	NN
cord-006229-7yoilsho	1505	24	weight	weight	NN
cord-006229-7yoilsho	1505	25	or	or	CC
cord-006229-7yoilsho	1505	26	isotonic	isotonic	JJ
cord-006229-7yoilsho	1505	27	sodium	sodium	NN
cord-006229-7yoilsho	1505	28	chloride	chloride	NN
cord-006229-7yoilsho	1505	29	solution	solution	NN
cord-006229-7yoilsho	1505	30	(	(	-LRB-
cord-006229-7yoilsho	1505	31	as	as	IN
cord-006229-7yoilsho	1505	32	solvent	solvent	NN
cord-006229-7yoilsho	1505	33	control	control	NN
cord-006229-7yoilsho	1505	34	)	)	-RRB-
cord-006229-7yoilsho	1505	35	.	.	.
cord-006229-7yoilsho	1506	1	Echocardiography	echocardiography	NN
cord-006229-7yoilsho	1506	2	with	with	IN
cord-006229-7yoilsho	1506	3	isoflurane	isoflurane	JJ
cord-006229-7yoilsho	1506	4	anesthesia	anesthesia	NN
cord-006229-7yoilsho	1506	5	was	be	VBD
cord-006229-7yoilsho	1506	6	performed	perform	VBN
cord-006229-7yoilsho	1506	7	before	before	RB
cord-006229-7yoilsho	1506	8	and	and	CC
cord-006229-7yoilsho	1506	9	3	3	CD
cord-006229-7yoilsho	1506	10	,	,	,
cord-006229-7yoilsho	1506	11	7	7	CD
cord-006229-7yoilsho	1506	12	and	and	CC
cord-006229-7yoilsho	1506	13	24	24	CD
cord-006229-7yoilsho	1506	14	hours	hour	NNS
cord-006229-7yoilsho	1506	15	after	after	IN
cord-006229-7yoilsho	1506	16	LPS	LPS	NNP
cord-006229-7yoilsho	1506	17	treatment	treatment	NN
cord-006229-7yoilsho	1506	18	.	.	.
cord-006229-7yoilsho	1507	1	LPS	LPS	NNP
cord-006229-7yoilsho	1507	2	led	lead	VBD
cord-006229-7yoilsho	1507	3	to	to	IN
cord-006229-7yoilsho	1507	4	a	a	DT
cord-006229-7yoilsho	1507	5	time	time	NN
cord-006229-7yoilsho	1507	6	-	-	HYPH
cord-006229-7yoilsho	1507	7	dependent	dependent	JJ
cord-006229-7yoilsho	1507	8	deterioration	deterioration	NN
cord-006229-7yoilsho	1507	9	of	of	IN
cord-006229-7yoilsho	1507	10	cardiac	cardiac	JJ
cord-006229-7yoilsho	1507	11	function	function	NN
cord-006229-7yoilsho	1507	12	in	in	IN
cord-006229-7yoilsho	1507	13	both	both	CC
cord-006229-7yoilsho	1507	14	TG	TG	NNP
cord-006229-7yoilsho	1507	15	and	and	CC
cord-006229-7yoilsho	1507	16	WT	WT	NNP
cord-006229-7yoilsho	1507	17	.	.	.
cord-006229-7yoilsho	1508	1	The	the	DT
cord-006229-7yoilsho	1508	2	deterioration	deterioration	NN
cord-006229-7yoilsho	1508	3	included	include	VBD
cord-006229-7yoilsho	1508	4	systolic	systolic	JJ
cord-006229-7yoilsho	1508	5	function	function	NN
cord-006229-7yoilsho	1508	6	(	(	-LRB-
cord-006229-7yoilsho	1508	7	left	leave	VBN
cord-006229-7yoilsho	1508	8	ventricular	ventricular	JJ
cord-006229-7yoilsho	1508	9	ejection	ejection	NN
cord-006229-7yoilsho	1508	10	fraction	fraction	NN
cord-006229-7yoilsho	1508	11	=	=	SYM
cord-006229-7yoilsho	1508	12	EF	EF	NNP
cord-006229-7yoilsho	1508	13	)	)	-RRB-
cord-006229-7yoilsho	1508	14	as	as	RB
cord-006229-7yoilsho	1508	15	well	well	RB
cord-006229-7yoilsho	1508	16	as	as	IN
cord-006229-7yoilsho	1508	17	diastolic	diastolic	JJ
cord-006229-7yoilsho	1508	18	function	function	NN
cord-006229-7yoilsho	1508	19	(	(	-LRB-
cord-006229-7yoilsho	1508	20	height	height	NN
cord-006229-7yoilsho	1508	21	of	of	IN
cord-006229-7yoilsho	1508	22	A	a	NN
cord-006229-7yoilsho	1508	23	and	and	CC
cord-006229-7yoilsho	1508	24	E	e	NN
cord-006229-7yoilsho	1508	25	waves	wave	NNS
cord-006229-7yoilsho	1508	26	through	through	IN
cord-006229-7yoilsho	1508	27	the	the	DT
cord-006229-7yoilsho	1508	28	mitral	mitral	JJ
cord-006229-7yoilsho	1508	29	valve	valve	NN
cord-006229-7yoilsho	1508	30	:	:	:
cord-006229-7yoilsho	1509	1	E	E	NNP
cord-006229-7yoilsho	1509	2	/	/	SYM
cord-006229-7yoilsho	1509	3	A	a	NN
cord-006229-7yoilsho	1509	4	)	)	-RRB-
cord-006229-7yoilsho	1509	5	.	.	.
cord-006229-7yoilsho	1510	1	For	for	IN
cord-006229-7yoilsho	1510	2	instance	instance	NN
cord-006229-7yoilsho	1510	3	,	,	,
cord-006229-7yoilsho	1510	4	EF	EF	NNP
cord-006229-7yoilsho	1510	5	amounted	amount	VBD
cord-006229-7yoilsho	1510	6	to	to	IN
cord-006229-7yoilsho	1510	7	58.8	58.8	CD
cord-006229-7yoilsho	1510	8	±	±	CD
cord-006229-7yoilsho	1510	9	20.7	20.7	CD
cord-006229-7yoilsho	1510	10	%	%	NN
cord-006229-7yoilsho	1510	11	seven	seven	CD
cord-006229-7yoilsho	1510	12	hours	hour	NNS
cord-006229-7yoilsho	1510	13	after	after	IN
cord-006229-7yoilsho	1510	14	LPS	LPS	NNP
cord-006229-7yoilsho	1510	15	in	in	IN
cord-006229-7yoilsho	1510	16	WT	WT	NNP
cord-006229-7yoilsho	1510	17	and	and	CC
cord-006229-7yoilsho	1510	18	to	to	IN
cord-006229-7yoilsho	1510	19	61	61	CD
cord-006229-7yoilsho	1510	20	.	.	.
cord-006229-7yoilsho	1511	1	[	[	-LRB-
cord-006229-7yoilsho	1511	2	4	4	CD
cord-006229-7yoilsho	1511	3	]	]	-RRB-
cord-006229-7yoilsho	1511	4	[	[	-LRB-
cord-006229-7yoilsho	1511	5	5	5	CD
cord-006229-7yoilsho	1511	6	]	]	-RRB-
cord-006229-7yoilsho	1511	7	[	[	-LRB-
cord-006229-7yoilsho	1511	8	6	6	CD
cord-006229-7yoilsho	1511	9	]	]	-RRB-
cord-006229-7yoilsho	1511	10	[	[	-LRB-
cord-006229-7yoilsho	1511	11	7	7	CD
cord-006229-7yoilsho	1511	12	]	]	-RRB-
cord-006229-7yoilsho	1512	1	[	[	-LRB-
cord-006229-7yoilsho	1512	2	8	8	CD
cord-006229-7yoilsho	1512	3	]	]	-RRB-
cord-006229-7yoilsho	1512	4	[	[	-LRB-
cord-006229-7yoilsho	1512	5	9	9	CD
cord-006229-7yoilsho	1512	6	]	]	-RRB-
cord-006229-7yoilsho	1512	7	[	[	-LRB-
cord-006229-7yoilsho	1512	8	10	10	CD
cord-006229-7yoilsho	1512	9	]	]	-RRB-
cord-006229-7yoilsho	1512	10	[	[	-LRB-
cord-006229-7yoilsho	1512	11	11	11	CD
cord-006229-7yoilsho	1512	12	]	]	-RRB-
cord-006229-7yoilsho	1512	13	[	[	-LRB-
cord-006229-7yoilsho	1512	14	12	12	CD
cord-006229-7yoilsho	1512	15	]	]	-RRB-
cord-006229-7yoilsho	1513	1	p<0	p<0	NNP
cord-006229-7yoilsho	1513	2	.05	.05	.
cord-006229-7yoilsho	1514	1	vs	vs	IN
cord-006229-7yoilsho	1514	2	pre	pre	JJ
cord-006229-7yoilsho	1514	3	-	-	JJ
cord-006229-7yoilsho	1514	4	LPS	lps	JJ
cord-006229-7yoilsho	1514	5	value	value	NN
cord-006229-7yoilsho	1514	6	)	)	-RRB-
cord-006229-7yoilsho	1514	7	.	.	.
cord-006229-7yoilsho	1515	1	However	however	RB
cord-006229-7yoilsho	1515	2	,	,	,
cord-006229-7yoilsho	1515	3	24	24	CD
cord-006229-7yoilsho	1515	4	hours	hour	NNS
cord-006229-7yoilsho	1515	5	after	after	IN
cord-006229-7yoilsho	1515	6	LPS	lp	NNS
cord-006229-7yoilsho	1515	7	,	,	,
cord-006229-7yoilsho	1515	8	diastolic	diastolic	JJ
cord-006229-7yoilsho	1515	9	function	function	NN
cord-006229-7yoilsho	1515	10	,	,	,
cord-006229-7yoilsho	1515	11	measured	measure	VBN
cord-006229-7yoilsho	1515	12	as	as	IN
cord-006229-7yoilsho	1515	13	E	E	NNP
cord-006229-7yoilsho	1515	14	/	/	SYM
cord-006229-7yoilsho	1515	15	A	A	NNP
cord-006229-7yoilsho	1515	16	,	,	,
cord-006229-7yoilsho	1515	17	amounted	amount	VBD
cord-006229-7yoilsho	1515	18	to	to	IN
cord-006229-7yoilsho	1515	19	1.86	1.86	CD
cord-006229-7yoilsho	1515	20	±	±	CD
cord-006229-7yoilsho	1515	21	0.43	0.43	CD
cord-006229-7yoilsho	1515	22	in	in	IN
cord-006229-7yoilsho	1515	23	p<0	p<0	NNP
cord-006229-7yoilsho	1515	24	.05	.05	.
cord-006229-7yoilsho	1516	1	TG	TG	NNP
cord-006229-7yoilsho	1516	2	vs.	vs.	IN
cord-006229-7yoilsho	1516	3	WT	WT	NNP
cord-006229-7yoilsho	1516	4	)	)	-RRB-
cord-006229-7yoilsho	1516	5	.	.	.
cord-006229-7yoilsho	1517	1	Moreover	moreover	RB
cord-006229-7yoilsho	1517	2	,	,	,
cord-006229-7yoilsho	1517	3	after	after	IN
cord-006229-7yoilsho	1517	4	24	24	CD
cord-006229-7yoilsho	1517	5	hours	hour	NNS
cord-006229-7yoilsho	1517	6	a	a	DT
cord-006229-7yoilsho	1517	7	less	less	RBR
cord-006229-7yoilsho	1517	8	pronounced	pronounced	JJ
cord-006229-7yoilsho	1517	9	decline	decline	NN
cord-006229-7yoilsho	1517	10	in	in	IN
cord-006229-7yoilsho	1517	11	body	body	NN
cord-006229-7yoilsho	1517	12	temperature	temperature	NN
cord-006229-7yoilsho	1517	13	(	(	-LRB-
cord-006229-7yoilsho	1517	14	probably	probably	RB
cord-006229-7yoilsho	1517	15	due	due	JJ
cord-006229-7yoilsho	1517	16	to	to	IN
cord-006229-7yoilsho	1517	17	superficial	superficial	JJ
cord-006229-7yoilsho	1517	18	abdominal	abdominal	JJ
cord-006229-7yoilsho	1517	19	hyperemia	hyperemia	NN
cord-006229-7yoilsho	1517	20	)	)	-RRB-
cord-006229-7yoilsho	1517	21	occurred	occur	VBD
cord-006229-7yoilsho	1517	22	in	in	IN
cord-006229-7yoilsho	1517	23	TG	TG	NNP
cord-006229-7yoilsho	1517	24	versus	versus	IN
cord-006229-7yoilsho	1517	25	WT	WT	NNP
cord-006229-7yoilsho	1517	26	.	.	.
cord-006229-7yoilsho	1518	1	In	in	IN
cord-006229-7yoilsho	1518	2	contrast	contrast	NN
cord-006229-7yoilsho	1518	3	,	,	,
cord-006229-7yoilsho	1518	4	while	while	IN
cord-006229-7yoilsho	1518	5	all	all	DT
cord-006229-7yoilsho	1518	6	flow	flow	NN
cord-006229-7yoilsho	1518	7	parameters	parameter	NNS
cord-006229-7yoilsho	1518	8	declined	decline	VBD
cord-006229-7yoilsho	1518	9	after	after	IN
cord-006229-7yoilsho	1518	10	3	3	CD
cord-006229-7yoilsho	1518	11	and	and	CC
cord-006229-7yoilsho	1518	12	7	7	CD
cord-006229-7yoilsho	1518	13	hours	hour	NNS
cord-006229-7yoilsho	1518	14	of	of	IN
cord-006229-7yoilsho	1518	15	LPS	lp	NNS
cord-006229-7yoilsho	1518	16	,	,	,
cord-006229-7yoilsho	1518	17	they	-PRON-	PRP
cord-006229-7yoilsho	1518	18	were	be	VBD
cord-006229-7yoilsho	1518	19	not	not	RB
cord-006229-7yoilsho	1518	20	different	different	JJ
cord-006229-7yoilsho	1518	21	between	between	IN
cord-006229-7yoilsho	1518	22	WT	WT	NNP
cord-006229-7yoilsho	1518	23	and	and	CC
cord-006229-7yoilsho	1518	24	TG	TG	NNP
cord-006229-7yoilsho	1518	25	.	.	.
cord-006229-7yoilsho	1519	1	For	for	IN
cord-006229-7yoilsho	1519	2	instance	instance	NN
cord-006229-7yoilsho	1519	3	,	,	,
cord-006229-7yoilsho	1519	4	maximum	maximum	JJ
cord-006229-7yoilsho	1519	5	flow	flow	NN
cord-006229-7yoilsho	1519	6	(	(	-LRB-
cord-006229-7yoilsho	1519	7	in	in	IN
cord-006229-7yoilsho	1519	8	mm	mm	NNP
cord-006229-7yoilsho	1519	9	/	/	SYM
cord-006229-7yoilsho	1519	10	s	s	NNP
cord-006229-7yoilsho	1519	11	)	)	-RRB-
cord-006229-7yoilsho	1519	12	through	through	IN
cord-006229-7yoilsho	1519	13	the	the	DT
cord-006229-7yoilsho	1519	14	ascending	ascend	VBG
cord-006229-7yoilsho	1519	15	aorta	aorta	NN
cord-006229-7yoilsho	1519	16	declined	decline	VBD
cord-006229-7yoilsho	1519	17	from	from	IN
cord-006229-7yoilsho	1519	18	1158.3	1158.3	CD
cord-006229-7yoilsho	1519	19	±	±	CD
cord-006229-7yoilsho	1519	20	212.2	212.2	CD
cord-006229-7yoilsho	1519	21	to	to	IN
cord-006229-7yoilsho	1519	22	782.5	782.5	CD
cord-006229-7yoilsho	1519	23	±	±	CD
cord-006229-7yoilsho	1519	24	154.3	154.3	CD
cord-006229-7yoilsho	1519	25	in	in	IN
cord-006229-7yoilsho	1519	26	WT	WT	NNP
cord-006229-7yoilsho	1519	27	and	and	CC
cord-006229-7yoilsho	1519	28	from	from	IN
cord-006229-7yoilsho	1519	29	1208.4	1208.4	CD
cord-006229-7yoilsho	1519	30	±	±	CD
cord-006229-7yoilsho	1519	31	235.1	235.1	CD
cord-006229-7yoilsho	1519	32	to	to	IN
cord-006229-7yoilsho	1519	33	798.8	798.8	CD
cord-006229-7yoilsho	1519	34	±	±	CD
cord-006229-7yoilsho	1519	35	170.1	170.1	CD
cord-006229-7yoilsho	1519	36	in	in	IN
cord-006229-7yoilsho	1519	37	TG	TG	NNP
cord-006229-7yoilsho	1519	38	(	(	-LRB-
cord-006229-7yoilsho	1519	39	TG	TG	NNP
cord-006229-7yoilsho	1519	40	vs.	vs.	IN
cord-006229-7yoilsho	1519	41	WT	WT	NNP
cord-006229-7yoilsho	1519	42	,	,	,
cord-006229-7yoilsho	1519	43	p>0.05	p>0.05	NNP
cord-006229-7yoilsho	1519	44	,	,	,
cord-006229-7yoilsho	1519	45	n=10	n=10	NNP
cord-006229-7yoilsho	1519	46	-	-	HYPH
cord-006229-7yoilsho	1519	47	12	12	CD
cord-006229-7yoilsho	1519	48	;	;	:
cord-006229-7yoilsho	1519	49	after	after	IN
cord-006229-7yoilsho	1519	50	7	7	CD
cord-006229-7yoilsho	1519	51	hours	hour	NNS
cord-006229-7yoilsho	1519	52	)	)	-RRB-
cord-006229-7yoilsho	1519	53	.	.	.
cord-006229-7yoilsho	1520	1	We	-PRON-	PRP
cord-006229-7yoilsho	1520	2	tentatively	tentatively	RB
cord-006229-7yoilsho	1520	3	conclude	conclude	VBP
cord-006229-7yoilsho	1520	4	:	:	:
cord-006229-7yoilsho	1520	5	5-HT	5-ht	CD
cord-006229-7yoilsho	1520	6	4	4	CD
cord-006229-7yoilsho	1520	7	-receptors	-receptor	NNS
cord-006229-7yoilsho	1520	8	overexpression	overexpression	NN
cord-006229-7yoilsho	1520	9	protects	protect	VBZ
cord-006229-7yoilsho	1520	10	the	the	DT
cord-006229-7yoilsho	1520	11	heart	heart	NN
cord-006229-7yoilsho	1520	12	against	against	IN
cord-006229-7yoilsho	1520	13	sepsis	sepsis	NN
cord-006229-7yoilsho	1520	14	,	,	,
cord-006229-7yoilsho	1520	15	putatively	putatively	RB
cord-006229-7yoilsho	1520	16	by	by	IN
cord-006229-7yoilsho	1520	17	interference	interference	NN
cord-006229-7yoilsho	1520	18	with	with	IN
cord-006229-7yoilsho	1520	19	the	the	DT
cord-006229-7yoilsho	1520	20	intracellular	intracellular	JJ
cord-006229-7yoilsho	1520	21	biochemical	biochemical	JJ
cord-006229-7yoilsho	1520	22	pathway	pathway	NN
cord-006229-7yoilsho	1520	23	of	of	IN
cord-006229-7yoilsho	1520	24	LPS	LPS	NNP
cord-006229-7yoilsho	1520	25	in	in	IN
cord-006229-7yoilsho	1520	26	cardiomyocytes	cardiomyocyte	NNS
cord-006229-7yoilsho	1520	27	.	.	.
cord-006229-7yoilsho	1521	1	Histamine	histamine	NN
cord-006229-7yoilsho	1521	2	can	can	MD
cord-006229-7yoilsho	1521	3	exert	exert	VB
cord-006229-7yoilsho	1521	4	positive	positive	JJ
cord-006229-7yoilsho	1521	5	inotropic	inotropic	NNP
cord-006229-7yoilsho	1521	6	and	and	CC
cord-006229-7yoilsho	1521	7	chronotropic	chronotropic	JJ
cord-006229-7yoilsho	1521	8	effects	effect	NNS
cord-006229-7yoilsho	1521	9	in	in	IN
cord-006229-7yoilsho	1521	10	humans	human	NNS
cord-006229-7yoilsho	1521	11	via	via	IN
cord-006229-7yoilsho	1521	12	histamine	histamine	NN
cord-006229-7yoilsho	1521	13	H	H	NNP
cord-006229-7yoilsho	1521	14	2	2	CD
cord-006229-7yoilsho	1521	15	-receptors	-receptor	NNS
cord-006229-7yoilsho	1521	16	.	.	.
cord-006229-7yoilsho	1522	1	We	-PRON-	PRP
cord-006229-7yoilsho	1522	2	have	have	VBP
cord-006229-7yoilsho	1522	3	generated	generate	VBN
cord-006229-7yoilsho	1522	4	transgenic	transgenic	JJ
cord-006229-7yoilsho	1522	5	mice	mouse	NNS
cord-006229-7yoilsho	1522	6	(	(	-LRB-
cord-006229-7yoilsho	1522	7	TG	TG	NNP
cord-006229-7yoilsho	1522	8	)	)	-RRB-
cord-006229-7yoilsho	1522	9	which	which	WDT
cord-006229-7yoilsho	1522	10	overexpress	overexpress	VBP
cord-006229-7yoilsho	1522	11	the	the	DT
cord-006229-7yoilsho	1522	12	human	human	JJ
cord-006229-7yoilsho	1522	13	H	h	NN
cord-006229-7yoilsho	1522	14	2	2	CD
cord-006229-7yoilsho	1522	15	-receptor	-receptor	NN
cord-006229-7yoilsho	1522	16	specifically	specifically	RB
cord-006229-7yoilsho	1522	17	in	in	IN
cord-006229-7yoilsho	1522	18	cardiomyocytes	cardiomyocyte	NNS
cord-006229-7yoilsho	1522	19	via	via	IN
cord-006229-7yoilsho	1522	20	the	the	DT
cord-006229-7yoilsho	1522	21	α	α	NN
cord-006229-7yoilsho	1522	22	-	-	HYPH
cord-006229-7yoilsho	1522	23	myosin	myosin	NN
cord-006229-7yoilsho	1522	24	heavy	heavy	JJ
cord-006229-7yoilsho	1522	25	chain	chain	NN
cord-006229-7yoilsho	1522	26	promoter	promoter	NN
cord-006229-7yoilsho	1522	27	.	.	.
cord-006229-7yoilsho	1523	1	In	in	IN
cord-006229-7yoilsho	1523	2	TG	TG	NNP
cord-006229-7yoilsho	1523	3	,	,	,
cord-006229-7yoilsho	1523	4	but	but	CC
cord-006229-7yoilsho	1523	5	not	not	RB
cord-006229-7yoilsho	1523	6	in	in	IN
cord-006229-7yoilsho	1523	7	wild	wild	JJ
cord-006229-7yoilsho	1523	8	type	type	NN
cord-006229-7yoilsho	1523	9	mice	mouse	NNS
cord-006229-7yoilsho	1523	10	(	(	-LRB-
cord-006229-7yoilsho	1523	11	WT	WT	NNP
cord-006229-7yoilsho	1523	12	)	)	-RRB-
cord-006229-7yoilsho	1523	13	,	,	,
cord-006229-7yoilsho	1523	14	histamine	histamine	NN
cord-006229-7yoilsho	1523	15	(	(	-LRB-
cord-006229-7yoilsho	1523	16	EC	EC	NNP
cord-006229-7yoilsho	1523	17	50	50	CD
cord-006229-7yoilsho	1523	18	=	=	SYM
cord-006229-7yoilsho	1523	19	34	34	CD
cord-006229-7yoilsho	1523	20	nM	nM	NNP
cord-006229-7yoilsho	1523	21	)	)	-RRB-
cord-006229-7yoilsho	1523	22	or	or	CC
cord-006229-7yoilsho	1523	23	amthamine	amthamine	JJ
cord-006229-7yoilsho	1523	24	(	(	-LRB-
cord-006229-7yoilsho	1523	25	EC	EC	NNP
cord-006229-7yoilsho	1523	26	50	50	CD
cord-006229-7yoilsho	1523	27	=	=	SYM
cord-006229-7yoilsho	1523	28	10	10	CD
cord-006229-7yoilsho	1523	29	nM	nM	NNP
cord-006229-7yoilsho	1523	30	)	)	-RRB-
cord-006229-7yoilsho	1523	31	,	,	,
cord-006229-7yoilsho	1523	32	a	a	DT
cord-006229-7yoilsho	1523	33	more	more	RBR
cord-006229-7yoilsho	1523	34	selective	selective	JJ
cord-006229-7yoilsho	1523	35	and	and	CC
cord-006229-7yoilsho	1523	36	potent	potent	JJ
cord-006229-7yoilsho	1523	37	H	h	NN
cord-006229-7yoilsho	1523	38	2	2	CD
cord-006229-7yoilsho	1523	39	-receptor	-receptor	NN
cord-006229-7yoilsho	1523	40	agonist	agonist	NN
cord-006229-7yoilsho	1523	41	,	,	,
cord-006229-7yoilsho	1523	42	induced	induce	VBD
cord-006229-7yoilsho	1523	43	positive	positive	JJ
cord-006229-7yoilsho	1523	44	inotropic	inotropic	JJ
cord-006229-7yoilsho	1523	45	effects	effect	NNS
cord-006229-7yoilsho	1523	46	(	(	-LRB-
cord-006229-7yoilsho	1523	47	PIE	pie	NN
cord-006229-7yoilsho	1523	48	)	)	-RRB-
cord-006229-7yoilsho	1523	49	and	and	CC
cord-006229-7yoilsho	1523	50	positive	positive	JJ
cord-006229-7yoilsho	1523	51	chronotropic	chronotropic	JJ
cord-006229-7yoilsho	1523	52	effects	effect	NNS
cord-006229-7yoilsho	1523	53	(	(	-LRB-
cord-006229-7yoilsho	1523	54	PCE	pce	NN
cord-006229-7yoilsho	1523	55	)	)	-RRB-
cord-006229-7yoilsho	1523	56	in	in	IN
cord-006229-7yoilsho	1523	57	isolated	isolate	VBN
cord-006229-7yoilsho	1523	58	left	left	JJ
cord-006229-7yoilsho	1523	59	and	and	CC
cord-006229-7yoilsho	1523	60	right	right	JJ
cord-006229-7yoilsho	1523	61	atrial	atrial	JJ
cord-006229-7yoilsho	1523	62	preparations	preparation	NNS
cord-006229-7yoilsho	1523	63	,	,	,
cord-006229-7yoilsho	1523	64	respectively	respectively	RB
cord-006229-7yoilsho	1523	65	.	.	.
cord-006229-7yoilsho	1524	1	In	in	IN
cord-006229-7yoilsho	1524	2	order	order	NN
cord-006229-7yoilsho	1524	3	to	to	TO
cord-006229-7yoilsho	1524	4	investigate	investigate	VB
cord-006229-7yoilsho	1524	5	the	the	DT
cord-006229-7yoilsho	1524	6	signal	signal	NN
cord-006229-7yoilsho	1524	7	transduction	transduction	NN
cord-006229-7yoilsho	1524	8	for	for	IN
cord-006229-7yoilsho	1524	9	the	the	DT
cord-006229-7yoilsho	1524	10	PIE	PIE	NNP
cord-006229-7yoilsho	1524	11	in	in	IN
cord-006229-7yoilsho	1524	12	atrium	atrium	NN
cord-006229-7yoilsho	1524	13	,	,	,
cord-006229-7yoilsho	1524	14	contractile	contractile	JJ
cord-006229-7yoilsho	1524	15	studies	study	NNS
cord-006229-7yoilsho	1524	16	using	use	VBG
cord-006229-7yoilsho	1524	17	partially	partially	RB
cord-006229-7yoilsho	1524	18	depolarized	depolarize	VBN
cord-006229-7yoilsho	1524	19	preparations	preparation	NNS
cord-006229-7yoilsho	1524	20	were	be	VBD
cord-006229-7yoilsho	1524	21	performed	perform	VBN
cord-006229-7yoilsho	1524	22	.	.	.
cord-006229-7yoilsho	1525	1	Therefore	therefore	RB
cord-006229-7yoilsho	1525	2	,	,	,
cord-006229-7yoilsho	1525	3	left	leave	VBN
cord-006229-7yoilsho	1525	4	atrial	atrial	JJ
cord-006229-7yoilsho	1525	5	preparations	preparation	NNS
cord-006229-7yoilsho	1525	6	were	be	VBD
cord-006229-7yoilsho	1525	7	equilibrated	equilibrate	VBN
cord-006229-7yoilsho	1525	8	in	in	IN
cord-006229-7yoilsho	1525	9	the	the	DT
cord-006229-7yoilsho	1525	10	organ	organ	NN
cord-006229-7yoilsho	1525	11	bath	bath	NN
cord-006229-7yoilsho	1525	12	to	to	IN
cord-006229-7yoilsho	1525	13	44	44	CD
cord-006229-7yoilsho	1525	14	mM	mm	CD
cord-006229-7yoilsho	1525	15	potassium	potassium	NN
cord-006229-7yoilsho	1525	16	chloride	chloride	NN
cord-006229-7yoilsho	1525	17	.	.	.
cord-006229-7yoilsho	1526	1	Thereafter	thereafter	RB
cord-006229-7yoilsho	1526	2	,	,	,
cord-006229-7yoilsho	1526	3	histamine	histamine	NN
cord-006229-7yoilsho	1526	4	(	(	-LRB-
cord-006229-7yoilsho	1526	5	100	100	CD
cord-006229-7yoilsho	1526	6	µM	µm	NN
cord-006229-7yoilsho	1526	7	)	)	-RRB-
cord-006229-7yoilsho	1526	8	induced	induce	VBD
cord-006229-7yoilsho	1526	9	a	a	DT
cord-006229-7yoilsho	1526	10	PIE	pie	NN
cord-006229-7yoilsho	1526	11	(	(	-LRB-
cord-006229-7yoilsho	1526	12	31.1	31.1	CD
cord-006229-7yoilsho	1526	13	±	±	CD
cord-006229-7yoilsho	1526	14	10.4	10.4	CD
cord-006229-7yoilsho	1526	15	%	%	NN
cord-006229-7yoilsho	1526	16	of	of	IN
cord-006229-7yoilsho	1526	17	control	control	NN
cord-006229-7yoilsho	1526	18	,	,	,
cord-006229-7yoilsho	1526	19	n=7	n=7	NNS
cord-006229-7yoilsho	1526	20	)	)	-RRB-
cord-006229-7yoilsho	1526	21	in	in	IN
cord-006229-7yoilsho	1526	22	TG	TG	NNP
cord-006229-7yoilsho	1526	23	but	but	CC
cord-006229-7yoilsho	1526	24	not	not	RB
cord-006229-7yoilsho	1526	25	in	in	IN
cord-006229-7yoilsho	1526	26	WT	WT	NNP
cord-006229-7yoilsho	1526	27	preparations	preparation	NNS
cord-006229-7yoilsho	1526	28	whereas	whereas	IN
cord-006229-7yoilsho	1526	29	isoprenaline	isoprenaline	NNP
cord-006229-7yoilsho	1526	30	(	(	-LRB-
cord-006229-7yoilsho	1526	31	10	10	CD
cord-006229-7yoilsho	1526	32	µM	µm	CD
cord-006229-7yoilsho	1526	33	)	)	-RRB-
cord-006229-7yoilsho	1526	34	increased	increase	VBN
cord-006229-7yoilsho	1526	35	force	force	NN
cord-006229-7yoilsho	1526	36	in	in	IN
cord-006229-7yoilsho	1526	37	both	both	CC
cord-006229-7yoilsho	1526	38	WT	WT	NNP
cord-006229-7yoilsho	1526	39	and	and	CC
cord-006229-7yoilsho	1526	40	TG	TG	NNP
cord-006229-7yoilsho	1526	41	.	.	.
cord-006229-7yoilsho	1527	1	The	the	DT
cord-006229-7yoilsho	1527	2	PIE	pie	NN
cord-006229-7yoilsho	1527	3	of	of	IN
cord-006229-7yoilsho	1527	4	histamine	histamine	NN
cord-006229-7yoilsho	1527	5	in	in	IN
cord-006229-7yoilsho	1527	6	potassium	potassium	NN
cord-006229-7yoilsho	1527	7	treated	treat	VBN
cord-006229-7yoilsho	1527	8	TG	TG	NNP
cord-006229-7yoilsho	1527	9	atrium	atrium	NN
cord-006229-7yoilsho	1527	10	could	could	MD
cord-006229-7yoilsho	1527	11	be	be	VB
cord-006229-7yoilsho	1527	12	blocked	block	VBN
cord-006229-7yoilsho	1527	13	by	by	IN
cord-006229-7yoilsho	1527	14	cimetidine	cimetidine	NN
cord-006229-7yoilsho	1527	15	.	.	.
cord-006229-7yoilsho	1528	1	Compound	Compound	NNP
cord-006229-7yoilsho	1528	2	48/80	48/80	CD
cord-006229-7yoilsho	1528	3	,	,	,
cord-006229-7yoilsho	1528	4	a	a	DT
cord-006229-7yoilsho	1528	5	releasing	release	VBG
cord-006229-7yoilsho	1528	6	agent	agent	NN
cord-006229-7yoilsho	1528	7	of	of	IN
cord-006229-7yoilsho	1528	8	endogenous	endogenous	JJ
cord-006229-7yoilsho	1528	9	histamine	histamine	NN
cord-006229-7yoilsho	1528	10	,	,	,
cord-006229-7yoilsho	1528	11	increased	increase	VBN
cord-006229-7yoilsho	1528	12	force	force	NN
cord-006229-7yoilsho	1528	13	of	of	IN
cord-006229-7yoilsho	1528	14	contraction	contraction	NN
cord-006229-7yoilsho	1528	15	in	in	IN
cord-006229-7yoilsho	1528	16	TG	TG	NNP
cord-006229-7yoilsho	1528	17	left	leave	VBD
cord-006229-7yoilsho	1528	18	atria	atria	NN
cord-006229-7yoilsho	1528	19	to	to	IN
cord-006229-7yoilsho	1528	20	a	a	DT
cord-006229-7yoilsho	1528	21	higher	high	JJR
cord-006229-7yoilsho	1528	22	extent	extent	NN
cord-006229-7yoilsho	1528	23	than	than	IN
cord-006229-7yoilsho	1528	24	in	in	IN
cord-006229-7yoilsho	1528	25	WT	WT	NNP
cord-006229-7yoilsho	1528	26	.	.	.
cord-006229-7yoilsho	1529	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	1529	2	,	,	,
cord-006229-7yoilsho	1529	3	we	-PRON-	PRP
cord-006229-7yoilsho	1529	4	tested	test	VBD
cord-006229-7yoilsho	1529	5	whether	whether	IN
cord-006229-7yoilsho	1529	6	analgetics	analgetic	NNS
cord-006229-7yoilsho	1529	7	known	know	VBN
cord-006229-7yoilsho	1529	8	to	to	TO
cord-006229-7yoilsho	1529	9	release	release	VB
cord-006229-7yoilsho	1529	10	histamine	histamine	NN
cord-006229-7yoilsho	1529	11	were	be	VBD
cord-006229-7yoilsho	1529	12	inotropically	inotropically	RB
cord-006229-7yoilsho	1529	13	active	active	JJ
cord-006229-7yoilsho	1529	14	in	in	IN
cord-006229-7yoilsho	1529	15	TG	TG	NNP
cord-006229-7yoilsho	1529	16	.	.	.
cord-006229-7yoilsho	1530	1	However	however	RB
cord-006229-7yoilsho	1530	2	,	,	,
cord-006229-7yoilsho	1530	3	morphine	morphine	NN
cord-006229-7yoilsho	1530	4	(	(	-LRB-
cord-006229-7yoilsho	1530	5	10	10	CD
cord-006229-7yoilsho	1530	6	µM	µm	NN
cord-006229-7yoilsho	1530	7	)	)	-RRB-
cord-006229-7yoilsho	1530	8	was	be	VBD
cord-006229-7yoilsho	1530	9	unable	unable	JJ
cord-006229-7yoilsho	1530	10	to	to	TO
cord-006229-7yoilsho	1530	11	affect	affect	VB
cord-006229-7yoilsho	1530	12	contractility	contractility	NN
cord-006229-7yoilsho	1530	13	in	in	IN
cord-006229-7yoilsho	1530	14	WT	WT	NNP
cord-006229-7yoilsho	1530	15	or	or	CC
cord-006229-7yoilsho	1530	16	TG	TG	NNP
cord-006229-7yoilsho	1530	17	,	,	,
cord-006229-7yoilsho	1530	18	whereas	whereas	IN
cord-006229-7yoilsho	1530	19	ketamine	ketamine	NN
cord-006229-7yoilsho	1530	20	and	and	CC
cord-006229-7yoilsho	1530	21	fentanyl	fentanyl	NN
cord-006229-7yoilsho	1530	22	increased	increase	VBD
cord-006229-7yoilsho	1530	23	left	left	JJ
cord-006229-7yoilsho	1530	24	atrial	atrial	JJ
cord-006229-7yoilsho	1530	25	contractility	contractility	NN
cord-006229-7yoilsho	1530	26	in	in	IN
cord-006229-7yoilsho	1530	27	both	both	CC
cord-006229-7yoilsho	1530	28	TG	TG	NNP
cord-006229-7yoilsho	1530	29	and	and	CC
cord-006229-7yoilsho	1530	30	WT	WT	NNP
cord-006229-7yoilsho	1530	31	.	.	.
cord-006229-7yoilsho	1531	1	In	in	IN
cord-006229-7yoilsho	1531	2	summary	summary	NN
cord-006229-7yoilsho	1531	3	,	,	,
cord-006229-7yoilsho	1531	4	we	-PRON-	PRP
cord-006229-7yoilsho	1531	5	demonstrated	demonstrate	VBD
cord-006229-7yoilsho	1531	6	an	an	DT
cord-006229-7yoilsho	1531	7	involvement	involvement	NN
cord-006229-7yoilsho	1531	8	of	of	IN
cord-006229-7yoilsho	1531	9	the	the	DT
cord-006229-7yoilsho	1531	10	L	l	NN
cord-006229-7yoilsho	1531	11	-	-	HYPH
cord-006229-7yoilsho	1531	12	type	type	NN
cord-006229-7yoilsho	1531	13	calcium	calcium	NN
cord-006229-7yoilsho	1531	14	channel	channel	NN
cord-006229-7yoilsho	1531	15	current	current	NN
cord-006229-7yoilsho	1531	16	in	in	IN
cord-006229-7yoilsho	1531	17	the	the	DT
cord-006229-7yoilsho	1531	18	H	H	NNP
cord-006229-7yoilsho	1531	19	2	2	CD
cord-006229-7yoilsho	1531	20	-receptor	-receptor	HYPH
cord-006229-7yoilsho	1531	21	mediated	mediate	VBN
cord-006229-7yoilsho	1531	22	PIE	PIE	NNP
cord-006229-7yoilsho	1531	23	in	in	IN
cord-006229-7yoilsho	1531	24	TG	TG	NNP
cord-006229-7yoilsho	1531	25	atria	atria	NN
cord-006229-7yoilsho	1531	26	.	.	.
cord-006229-7yoilsho	1532	1	We	-PRON-	PRP
cord-006229-7yoilsho	1532	2	failed	fail	VBD
cord-006229-7yoilsho	1532	3	to	to	TO
cord-006229-7yoilsho	1532	4	release	release	VB
cord-006229-7yoilsho	1532	5	inotropically	inotropically	RB
cord-006229-7yoilsho	1532	6	active	active	JJ
cord-006229-7yoilsho	1532	7	histamine	histamine	NN
cord-006229-7yoilsho	1532	8	using	use	VBG
cord-006229-7yoilsho	1532	9	classical	classical	JJ
cord-006229-7yoilsho	1532	10	analgetics	analgetic	NNS
cord-006229-7yoilsho	1532	11	,	,	,
cord-006229-7yoilsho	1532	12	arguing	argue	VBG
cord-006229-7yoilsho	1532	13	that	that	IN
cord-006229-7yoilsho	1532	14	a	a	DT
cord-006229-7yoilsho	1532	15	direct	direct	JJ
cord-006229-7yoilsho	1532	16	effect	effect	NN
cord-006229-7yoilsho	1532	17	also	also	RB
cord-006229-7yoilsho	1532	18	in	in	IN
cord-006229-7yoilsho	1532	19	the	the	DT
cord-006229-7yoilsho	1532	20	human	human	JJ
cord-006229-7yoilsho	1532	21	heart	heart	NN
cord-006229-7yoilsho	1532	22	is	be	VBZ
cord-006229-7yoilsho	1532	23	unlikely	unlikely	JJ
cord-006229-7yoilsho	1532	24	to	to	TO
cord-006229-7yoilsho	1532	25	occur	occur	VB
cord-006229-7yoilsho	1532	26	.	.	.
cord-006229-7yoilsho	1533	1	The	the	DT
cord-006229-7yoilsho	1533	2	initial	initial	JJ
cord-006229-7yoilsho	1533	3	step	step	NN
cord-006229-7yoilsho	1533	4	in	in	IN
cord-006229-7yoilsho	1533	5	the	the	DT
cord-006229-7yoilsho	1533	6	homologous	homologous	JJ
cord-006229-7yoilsho	1533	7	desensitization	desensitization	NN
cord-006229-7yoilsho	1533	8	of	of	IN
cord-006229-7yoilsho	1533	9	G	g	NN
cord-006229-7yoilsho	1533	10	-	-	HYPH
cord-006229-7yoilsho	1533	11	protein	protein	NN
cord-006229-7yoilsho	1533	12	-	-	HYPH
cord-006229-7yoilsho	1533	13	coupled	couple	VBN
cord-006229-7yoilsho	1533	14	receptors	receptor	NNS
cord-006229-7yoilsho	1533	15	is	be	VBZ
cord-006229-7yoilsho	1533	16	their	-PRON-	PRP$
cord-006229-7yoilsho	1533	17	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	1533	18	by	by	IN
cord-006229-7yoilsho	1533	19	one	one	CD
cord-006229-7yoilsho	1533	20	of	of	IN
cord-006229-7yoilsho	1533	21	the	the	DT
cord-006229-7yoilsho	1533	22	G	g	NN
cord-006229-7yoilsho	1533	23	-	-	HYPH
cord-006229-7yoilsho	1533	24	protein	protein	NN
cord-006229-7yoilsho	1533	25	-	-	HYPH
cord-006229-7yoilsho	1533	26	coupled	couple	VBN
cord-006229-7yoilsho	1533	27	receptor	receptor	NN
cord-006229-7yoilsho	1533	28	kinases	kinase	NNS
cord-006229-7yoilsho	1533	29	(	(	-LRB-
cord-006229-7yoilsho	1533	30	GRKs	GRKs	NNP
cord-006229-7yoilsho	1533	31	)	)	-RRB-
cord-006229-7yoilsho	1533	32	.	.	.
cord-006229-7yoilsho	1534	1	We	-PRON-	PRP
cord-006229-7yoilsho	1534	2	demonstrate	demonstrate	VBP
cord-006229-7yoilsho	1534	3	here	here	RB
cord-006229-7yoilsho	1534	4	measurement	measurement	NN
cord-006229-7yoilsho	1534	5	of	of	IN
cord-006229-7yoilsho	1534	6	the	the	DT
cord-006229-7yoilsho	1534	7	interaction	interaction	NN
cord-006229-7yoilsho	1534	8	of	of	IN
cord-006229-7yoilsho	1534	9	GRK2	GRK2	NNP
cord-006229-7yoilsho	1534	10	,	,	,
cord-006229-7yoilsho	1534	11	a	a	DT
cord-006229-7yoilsho	1534	12	ubiquitously	ubiquitously	RB
cord-006229-7yoilsho	1534	13	expressed	express	VBN
cord-006229-7yoilsho	1534	14	GRK	GRK	NNP
cord-006229-7yoilsho	1534	15	,	,	,
cord-006229-7yoilsho	1534	16	with	with	IN
cord-006229-7yoilsho	1534	17	the	the	DT
cord-006229-7yoilsho	1534	18	μ	μ	NN
cord-006229-7yoilsho	1534	19	-	-	HYPH
cord-006229-7yoilsho	1534	20	opioid	opioid	NN
cord-006229-7yoilsho	1534	21	receptor	receptor	NN
cord-006229-7yoilsho	1534	22	(	(	-LRB-
cord-006229-7yoilsho	1534	23	µOR	µOR	NNP
cord-006229-7yoilsho	1534	24	)	)	-RRB-
cord-006229-7yoilsho	1534	25	by	by	IN
cord-006229-7yoilsho	1534	26	FRET	fret	NN
cord-006229-7yoilsho	1534	27	and	and	CC
cord-006229-7yoilsho	1534	28	its	-PRON-	PRP$
cord-006229-7yoilsho	1534	29	dependence	dependence	NN
cord-006229-7yoilsho	1534	30	on	on	IN
cord-006229-7yoilsho	1534	31	agonist	agonist	JJ
cord-006229-7yoilsho	1534	32	efficacy	efficacy	NN
cord-006229-7yoilsho	1534	33	.	.	.
cord-006229-7yoilsho	1535	1	HEK293	HEK293	NNP
cord-006229-7yoilsho	1535	2	T	t	NN
cord-006229-7yoilsho	1535	3	cells	cell	NNS
cord-006229-7yoilsho	1535	4	transfected	transfecte	VBN
cord-006229-7yoilsho	1535	5	with	with	IN
cord-006229-7yoilsho	1535	6	YFP	YFP	NNP
cord-006229-7yoilsho	1535	7	-	-	HYPH
cord-006229-7yoilsho	1535	8	tagged	tagged	NNP
cord-006229-7yoilsho	1535	9	µOR	µOR	NNP
cord-006229-7yoilsho	1535	10	and	and	CC
cord-006229-7yoilsho	1535	11	mTurquoise	mTurquoise	NNP
cord-006229-7yoilsho	1535	12	-	-	HYPH
cord-006229-7yoilsho	1535	13	tagged	tagged	NNP
cord-006229-7yoilsho	1535	14	GRK2	GRK2	NNP
cord-006229-7yoilsho	1535	15	as	as	RB
cord-006229-7yoilsho	1535	16	well	well	RB
cord-006229-7yoilsho	1535	17	as	as	IN
cord-006229-7yoilsho	1535	18	non	non	JJ
cord-006229-7yoilsho	1535	19	-	-	JJ
cord-006229-7yoilsho	1535	20	fluorescent	fluorescent	JJ
cord-006229-7yoilsho	1535	21	Gα	Gα	NNP
cord-006229-7yoilsho	1535	22	i1	i1	NN
cord-006229-7yoilsho	1535	23	,	,	,
cord-006229-7yoilsho	1535	24	Gβ	Gβ	NNP
cord-006229-7yoilsho	1535	25	and	and	CC
cord-006229-7yoilsho	1535	26	Gγ	Gγ	NNP
cord-006229-7yoilsho	1535	27	subunits	subunit	NNS
cord-006229-7yoilsho	1535	28	showed	show	VBD
cord-006229-7yoilsho	1535	29	a	a	DT
cord-006229-7yoilsho	1535	30	robust	robust	JJ
cord-006229-7yoilsho	1535	31	increase	increase	NN
cord-006229-7yoilsho	1535	32	in	in	IN
cord-006229-7yoilsho	1535	33	FRET	fret	NN
cord-006229-7yoilsho	1535	34	upon	upon	IN
cord-006229-7yoilsho	1535	35	superfusion	superfusion	NN
cord-006229-7yoilsho	1535	36	with	with	IN
cord-006229-7yoilsho	1535	37	10	10	CD
cord-006229-7yoilsho	1535	38	µM	µm	NN
cord-006229-7yoilsho	1536	1	[	[	-LRB-
cord-006229-7yoilsho	1536	2	D	D	NNP
cord-006229-7yoilsho	1536	3	-	-	HYPH
cord-006229-7yoilsho	1536	4	Ala	Ala	NNP
cord-006229-7yoilsho	1536	5	2	2	CD
cord-006229-7yoilsho	1536	6	,	,	,
cord-006229-7yoilsho	1536	7	N	N	NNP
cord-006229-7yoilsho	1536	8	-	-	HYPH
cord-006229-7yoilsho	1536	9	MePhe	MePhe	NNP
cord-006229-7yoilsho	1536	10	4	4	CD
cord-006229-7yoilsho	1536	11	,	,	,
cord-006229-7yoilsho	1536	12	Gly	Gly	NNP
cord-006229-7yoilsho	1536	13	-	-	HYPH
cord-006229-7yoilsho	1536	14	ol]-enkephalin	ol]-enkephalin	NNP
cord-006229-7yoilsho	1537	1	(	(	-LRB-
cord-006229-7yoilsho	1537	2	DAMGO	DAMGO	NNP
cord-006229-7yoilsho	1537	3	)	)	-RRB-
cord-006229-7yoilsho	1537	4	which	which	WDT
cord-006229-7yoilsho	1537	5	was	be	VBD
cord-006229-7yoilsho	1537	6	reversible	reversible	JJ
cord-006229-7yoilsho	1537	7	upon	upon	IN
cord-006229-7yoilsho	1537	8	agonist	agonist	NN
cord-006229-7yoilsho	1537	9	washout	washout	NN
cord-006229-7yoilsho	1537	10	.	.	.
cord-006229-7yoilsho	1538	1	The	the	DT
cord-006229-7yoilsho	1538	2	partial	partial	JJ
cord-006229-7yoilsho	1538	3	agonist	agonist	NN
cord-006229-7yoilsho	1538	4	morphine	morphine	NN
cord-006229-7yoilsho	1538	5	(	(	-LRB-
cord-006229-7yoilsho	1538	6	30	30	CD
cord-006229-7yoilsho	1538	7	µM	µm	NN
cord-006229-7yoilsho	1538	8	)	)	-RRB-
cord-006229-7yoilsho	1538	9	also	also	RB
cord-006229-7yoilsho	1538	10	caused	cause	VBD
cord-006229-7yoilsho	1538	11	a	a	DT
cord-006229-7yoilsho	1538	12	FRET	fret	NN
cord-006229-7yoilsho	1538	13	increase	increase	NN
cord-006229-7yoilsho	1538	14	but	but	CC
cord-006229-7yoilsho	1538	15	the	the	DT
cord-006229-7yoilsho	1538	16	amplitude	amplitude	NN
cord-006229-7yoilsho	1538	17	of	of	IN
cord-006229-7yoilsho	1538	18	the	the	DT
cord-006229-7yoilsho	1538	19	FRET	fret	NN
cord-006229-7yoilsho	1538	20	signal	signal	NN
cord-006229-7yoilsho	1538	21	was	be	VBD
cord-006229-7yoilsho	1538	22	reduced	reduce	VBN
cord-006229-7yoilsho	1538	23	to	to	IN
cord-006229-7yoilsho	1538	24	approximately	approximately	RB
cord-006229-7yoilsho	1538	25	15	15	CD
cord-006229-7yoilsho	1538	26	-	-	SYM
cord-006229-7yoilsho	1538	27	20	20	CD
cord-006229-7yoilsho	1538	28	%	%	NN
cord-006229-7yoilsho	1538	29	of	of	IN
cord-006229-7yoilsho	1538	30	that	that	DT
cord-006229-7yoilsho	1538	31	of	of	IN
cord-006229-7yoilsho	1538	32	the	the	DT
cord-006229-7yoilsho	1538	33	corresponding	correspond	VBG
cord-006229-7yoilsho	1538	34	DAMGO	DAMGO	NNP
cord-006229-7yoilsho	1538	35	signal	signal	NN
cord-006229-7yoilsho	1538	36	.	.	.
cord-006229-7yoilsho	1539	1	GRK2	GRK2	NNP
cord-006229-7yoilsho	1539	2	binds	bind	VBZ
cord-006229-7yoilsho	1539	3	G	g	NN
cord-006229-7yoilsho	1539	4	-	-	HYPH
cord-006229-7yoilsho	1539	5	protein	protein	NN
cord-006229-7yoilsho	1539	6	βγ	βγ	NN
cord-006229-7yoilsho	1539	7	(	(	-LRB-
cord-006229-7yoilsho	1539	8	Gβγ	Gβγ	NNP
cord-006229-7yoilsho	1539	9	)	)	-RRB-
cord-006229-7yoilsho	1539	10	subunits	subunit	NNS
cord-006229-7yoilsho	1539	11	,	,	,
cord-006229-7yoilsho	1539	12	and	and	CC
cord-006229-7yoilsho	1539	13	therefore	therefore	RB
cord-006229-7yoilsho	1539	14	we	-PRON-	PRP
cord-006229-7yoilsho	1539	15	aimed	aim	VBD
cord-006229-7yoilsho	1539	16	to	to	TO
cord-006229-7yoilsho	1539	17	find	find	VB
cord-006229-7yoilsho	1539	18	out	out	RP
cord-006229-7yoilsho	1539	19	how	how	WRB
cord-006229-7yoilsho	1539	20	cotransfection	cotransfection	NN
cord-006229-7yoilsho	1539	21	of	of	IN
cord-006229-7yoilsho	1539	22	GRK2	GRK2	NNP
cord-006229-7yoilsho	1539	23	affected	affect	VBD
cord-006229-7yoilsho	1539	24	the	the	DT
cord-006229-7yoilsho	1539	25	interaction	interaction	NN
cord-006229-7yoilsho	1539	26	of	of	IN
cord-006229-7yoilsho	1539	27	Gβγ	Gβγ	NNP
cord-006229-7yoilsho	1539	28	with	with	IN
cord-006229-7yoilsho	1539	29	the	the	DT
cord-006229-7yoilsho	1539	30	µOR	µOR	NNP
cord-006229-7yoilsho	1539	31	.	.	.
cord-006229-7yoilsho	1540	1	However	however	RB
cord-006229-7yoilsho	1540	2	,	,	,
cord-006229-7yoilsho	1540	3	we	-PRON-	PRP
cord-006229-7yoilsho	1540	4	could	could	MD
cord-006229-7yoilsho	1540	5	not	not	RB
cord-006229-7yoilsho	1540	6	measure	measure	VB
cord-006229-7yoilsho	1540	7	any	any	DT
cord-006229-7yoilsho	1540	8	DAMGO	DAMGO	NNP
cord-006229-7yoilsho	1540	9	-	-	HYPH
cord-006229-7yoilsho	1540	10	induced	induce	VBN
cord-006229-7yoilsho	1540	11	FRET	fret	NN
cord-006229-7yoilsho	1540	12	changes	change	NNS
cord-006229-7yoilsho	1540	13	between	between	IN
cord-006229-7yoilsho	1540	14	YFP	YFP	NNP
cord-006229-7yoilsho	1540	15	-	-	HYPH
cord-006229-7yoilsho	1540	16	tagged	tagged	NNP
cord-006229-7yoilsho	1540	17	µOR	µOR	NNP
cord-006229-7yoilsho	1540	18	and	and	CC
cord-006229-7yoilsho	1540	19	mTurquoise	mTurquoise	NNP
cord-006229-7yoilsho	1540	20	-	-	HYPH
cord-006229-7yoilsho	1540	21	tagged	tag	VBN
cord-006229-7yoilsho	1540	22	Gβ	Gβ	NNP
cord-006229-7yoilsho	1540	23	in	in	IN
cord-006229-7yoilsho	1540	24	the	the	DT
cord-006229-7yoilsho	1540	25	presence	presence	NN
cord-006229-7yoilsho	1540	26	of	of	IN
cord-006229-7yoilsho	1540	27	non	non	JJ
cord-006229-7yoilsho	1540	28	-	-	JJ
cord-006229-7yoilsho	1540	29	fluorescent	fluorescent	JJ
cord-006229-7yoilsho	1540	30	Gα	Gα	NNP
cord-006229-7yoilsho	1540	31	i1	i1	NN
cord-006229-7yoilsho	1540	32	and	and	CC
cord-006229-7yoilsho	1540	33	Gγ	Gγ	NNP
cord-006229-7yoilsho	1540	34	.	.	.
cord-006229-7yoilsho	1541	1	This	this	DT
cord-006229-7yoilsho	1541	2	was	be	VBD
cord-006229-7yoilsho	1541	3	unexpected	unexpected	JJ
cord-006229-7yoilsho	1541	4	because	because	IN
cord-006229-7yoilsho	1541	5	we	-PRON-	PRP
cord-006229-7yoilsho	1541	6	had	have	VBD
cord-006229-7yoilsho	1541	7	previously	previously	RB
cord-006229-7yoilsho	1541	8	successfully	successfully	RB
cord-006229-7yoilsho	1541	9	determined	determine	VBN
cord-006229-7yoilsho	1541	10	interactions	interaction	NNS
cord-006229-7yoilsho	1541	11	between	between	IN
cord-006229-7yoilsho	1541	12	Gβγ	Gβγ	NNP
cord-006229-7yoilsho	1541	13	and	and	CC
cord-006229-7yoilsho	1541	14	the	the	DT
cord-006229-7yoilsho	1541	15	α	α	NNP
cord-006229-7yoilsho	1541	16	2A	2a	CD
cord-006229-7yoilsho	1541	17	-adrenergic	-adrenergic	JJ
cord-006229-7yoilsho	1541	18	receptor	receptor	NN
cord-006229-7yoilsho	1541	19	or	or	CC
cord-006229-7yoilsho	1541	20	the	the	DT
cord-006229-7yoilsho	1541	21	M	M	NNP
cord-006229-7yoilsho	1541	22	3	3	CD
cord-006229-7yoilsho	1541	23	muscarinic	muscarinic	JJ
cord-006229-7yoilsho	1541	24	acetylcholine	acetylcholine	NN
cord-006229-7yoilsho	1541	25	receptor	receptor	NN
cord-006229-7yoilsho	1541	26	.	.	.
cord-006229-7yoilsho	1542	1	This	this	DT
cord-006229-7yoilsho	1542	2	lack	lack	NN
cord-006229-7yoilsho	1542	3	of	of	IN
cord-006229-7yoilsho	1542	4	FRET	fret	NN
cord-006229-7yoilsho	1542	5	was	be	VBD
cord-006229-7yoilsho	1542	6	not	not	RB
cord-006229-7yoilsho	1542	7	due	due	JJ
cord-006229-7yoilsho	1542	8	to	to	IN
cord-006229-7yoilsho	1542	9	an	an	DT
cord-006229-7yoilsho	1542	10	inability	inability	NN
cord-006229-7yoilsho	1542	11	of	of	IN
cord-006229-7yoilsho	1542	12	the	the	DT
cord-006229-7yoilsho	1542	13	tagged	tagged	NNP
cord-006229-7yoilsho	1542	14	Gβ	Gβ	NNP
cord-006229-7yoilsho	1542	15	to	to	TO
cord-006229-7yoilsho	1542	16	interact	interact	VB
cord-006229-7yoilsho	1542	17	with	with	IN
cord-006229-7yoilsho	1542	18	the	the	DT
cord-006229-7yoilsho	1542	19	µOR	µOR	NNP
cord-006229-7yoilsho	1542	20	as	as	IN
cord-006229-7yoilsho	1542	21	we	-PRON-	PRP
cord-006229-7yoilsho	1542	22	could	could	MD
cord-006229-7yoilsho	1542	23	measure	measure	VB
cord-006229-7yoilsho	1542	24	DAMGO	DAMGO	NNP
cord-006229-7yoilsho	1542	25	-	-	HYPH
cord-006229-7yoilsho	1542	26	induced	induce	VBN
cord-006229-7yoilsho	1542	27	FRET	fret	NN
cord-006229-7yoilsho	1542	28	changes	change	NNS
cord-006229-7yoilsho	1542	29	between	between	IN
cord-006229-7yoilsho	1542	30	YFP	YFP	NNP
cord-006229-7yoilsho	1542	31	-	-	HYPH
cord-006229-7yoilsho	1542	32	tagged	tag	VBN
cord-006229-7yoilsho	1542	33	Gα	Gα	NNP
cord-006229-7yoilsho	1542	34	i1	i1	NN
cord-006229-7yoilsho	1542	35	and	and	CC
cord-006229-7yoilsho	1542	36	Gβγ	Gβγ	NNP
cord-006229-7yoilsho	1543	1	(	(	-LRB-
cord-006229-7yoilsho	1543	2	Gβ	Gβ	NNP
cord-006229-7yoilsho	1543	3	tagged	tag	VBN
cord-006229-7yoilsho	1543	4	with	with	IN
cord-006229-7yoilsho	1543	5	mTurquoise	mTurquoise	NNP
cord-006229-7yoilsho	1543	6	)	)	-RRB-
cord-006229-7yoilsho	1543	7	in	in	IN
cord-006229-7yoilsho	1543	8	the	the	DT
cord-006229-7yoilsho	1543	9	presence	presence	NN
cord-006229-7yoilsho	1543	10	of	of	IN
cord-006229-7yoilsho	1543	11	non	non	JJ
cord-006229-7yoilsho	1543	12	-	-	JJ
cord-006229-7yoilsho	1543	13	fluorescent	fluorescent	JJ
cord-006229-7yoilsho	1543	14	µOR	µor	NN
cord-006229-7yoilsho	1543	15	.	.	.
cord-006229-7yoilsho	1544	1	Moreover	moreover	RB
cord-006229-7yoilsho	1544	2	,	,	,
cord-006229-7yoilsho	1544	3	when	when	WRB
cord-006229-7yoilsho	1544	4	we	-PRON-	PRP
cord-006229-7yoilsho	1544	5	attempted	attempt	VBD
cord-006229-7yoilsho	1544	6	to	to	TO
cord-006229-7yoilsho	1544	7	establish	establish	VB
cord-006229-7yoilsho	1544	8	an	an	DT
cord-006229-7yoilsho	1544	9	effect	effect	NN
cord-006229-7yoilsho	1544	10	of	of	IN
cord-006229-7yoilsho	1544	11	GRK2	GRK2	NNP
cord-006229-7yoilsho	1544	12	on	on	IN
cord-006229-7yoilsho	1544	13	the	the	DT
cord-006229-7yoilsho	1544	14	interaction	interaction	NN
cord-006229-7yoilsho	1544	15	between	between	IN
cord-006229-7yoilsho	1544	16	the	the	DT
cord-006229-7yoilsho	1544	17	µOR	µOR	NNP
cord-006229-7yoilsho	1544	18	and	and	CC
cord-006229-7yoilsho	1544	19	Gβγ	Gβγ	NNP
cord-006229-7yoilsho	1544	20	,	,	,
cord-006229-7yoilsho	1544	21	we	-PRON-	PRP
cord-006229-7yoilsho	1544	22	could	could	MD
cord-006229-7yoilsho	1544	23	pick	pick	VB
cord-006229-7yoilsho	1544	24	up	up	RP
cord-006229-7yoilsho	1544	25	FRET	fret	NN
cord-006229-7yoilsho	1544	26	between	between	IN
cord-006229-7yoilsho	1544	27	the	the	DT
cord-006229-7yoilsho	1544	28	µOR	µOR	NNP
cord-006229-7yoilsho	1544	29	and	and	CC
cord-006229-7yoilsho	1544	30	Gβγ	Gβγ	NNP
cord-006229-7yoilsho	1544	31	.	.	.
cord-006229-7yoilsho	1545	1	Comparison	comparison	NN
cord-006229-7yoilsho	1545	2	of	of	IN
cord-006229-7yoilsho	1545	3	the	the	DT
cord-006229-7yoilsho	1545	4	on	on	NN
cord-006229-7yoilsho	1545	5	-	-	HYPH
cord-006229-7yoilsho	1545	6	and	and	CC
cord-006229-7yoilsho	1545	7	off	off	NNS
cord-006229-7yoilsho	1545	8	-	-	HYPH
cord-006229-7yoilsho	1545	9	kinetics	kinetic	NNS
cord-006229-7yoilsho	1545	10	of	of	IN
cord-006229-7yoilsho	1545	11	the	the	DT
cord-006229-7yoilsho	1545	12	µOR	µOR	NNP
cord-006229-7yoilsho	1545	13	-	-	HYPH
cord-006229-7yoilsho	1545	14	GRK2	GRK2	NNP
cord-006229-7yoilsho	1545	15	interaction	interaction	NN
cord-006229-7yoilsho	1545	16	with	with	IN
cord-006229-7yoilsho	1545	17	that	that	DT
cord-006229-7yoilsho	1545	18	of	of	IN
cord-006229-7yoilsho	1545	19	the	the	DT
cord-006229-7yoilsho	1545	20	µOR	µOR	NNP
cord-006229-7yoilsho	1545	21	-	-	HYPH
cord-006229-7yoilsho	1545	22	Gβγ	Gβγ	NNP
cord-006229-7yoilsho	1545	23	interaction	interaction	NN
cord-006229-7yoilsho	1545	24	in	in	IN
cord-006229-7yoilsho	1545	25	the	the	DT
cord-006229-7yoilsho	1545	26	presence	presence	NN
cord-006229-7yoilsho	1545	27	of	of	IN
cord-006229-7yoilsho	1545	28	GRK2	GRK2	NNP
cord-006229-7yoilsho	1545	29	revealed	reveal	VBD
cord-006229-7yoilsho	1545	30	similar	similar	JJ
cord-006229-7yoilsho	1545	31	time	time	NN
cord-006229-7yoilsho	1545	32	constants	constant	NNS
cord-006229-7yoilsho	1545	33	both	both	DT
cord-006229-7yoilsho	1545	34	for	for	IN
cord-006229-7yoilsho	1545	35	the	the	DT
cord-006229-7yoilsho	1545	36	on	on	NN
cord-006229-7yoilsho	1545	37	-	-	HYPH
cord-006229-7yoilsho	1545	38	and	and	CC
cord-006229-7yoilsho	1545	39	off	off	JJ
cord-006229-7yoilsho	1545	40	-	-	HYPH
cord-006229-7yoilsho	1545	41	kinetics	kinetics	NN
cord-006229-7yoilsho	1545	42	(	(	-LRB-
cord-006229-7yoilsho	1545	43	GRK2	GRK2	NNP
cord-006229-7yoilsho	1545	44	:	:	:
cord-006229-7yoilsho	1546	1	k	k	NNP
cord-006229-7yoilsho	1546	2	on	on	IN
cord-006229-7yoilsho	1546	3	0.16	0.16	CD
cord-006229-7yoilsho	1546	4	s	s	NNS
cord-006229-7yoilsho	1546	5	)	)	-RRB-
cord-006229-7yoilsho	1546	6	.	.	.
cord-006229-7yoilsho	1547	1	This	this	DT
cord-006229-7yoilsho	1547	2	suggests	suggest	VBZ
cord-006229-7yoilsho	1547	3	that	that	IN
cord-006229-7yoilsho	1547	4	,	,	,
cord-006229-7yoilsho	1547	5	in	in	IN
cord-006229-7yoilsho	1547	6	the	the	DT
cord-006229-7yoilsho	1547	7	absence	absence	NN
cord-006229-7yoilsho	1547	8	of	of	IN
cord-006229-7yoilsho	1547	9	GRK2	GRK2	NNP
cord-006229-7yoilsho	1547	10	,	,	,
cord-006229-7yoilsho	1547	11	the	the	DT
cord-006229-7yoilsho	1547	12	orientation	orientation	NN
cord-006229-7yoilsho	1547	13	of	of	IN
cord-006229-7yoilsho	1547	14	the	the	DT
cord-006229-7yoilsho	1547	15	two	two	CD
cord-006229-7yoilsho	1547	16	fluorophores	fluorophore	NNS
cord-006229-7yoilsho	1547	17	on	on	IN
cord-006229-7yoilsho	1547	18	the	the	DT
cord-006229-7yoilsho	1547	19	µOR	µOR	NNP
cord-006229-7yoilsho	1547	20	and	and	CC
cord-006229-7yoilsho	1547	21	Gβγ	Gβγ	NNP
cord-006229-7yoilsho	1547	22	may	may	MD
cord-006229-7yoilsho	1547	23	be	be	VB
cord-006229-7yoilsho	1547	24	unfavorable	unfavorable	JJ
cord-006229-7yoilsho	1547	25	or	or	CC
cord-006229-7yoilsho	1547	26	the	the	DT
cord-006229-7yoilsho	1547	27	interaction	interaction	NN
cord-006229-7yoilsho	1547	28	may	may	MD
cord-006229-7yoilsho	1547	29	be	be	VB
cord-006229-7yoilsho	1547	30	too	too	RB
cord-006229-7yoilsho	1547	31	short	short	RB
cord-006229-7yoilsho	1547	32	-	-	HYPH
cord-006229-7yoilsho	1547	33	lived	live	VBN
cord-006229-7yoilsho	1547	34	to	to	TO
cord-006229-7yoilsho	1547	35	produce	produce	VB
cord-006229-7yoilsho	1547	36	an	an	DT
cord-006229-7yoilsho	1547	37	appreciable	appreciable	JJ
cord-006229-7yoilsho	1547	38	FRET	fret	NN
cord-006229-7yoilsho	1547	39	signal	signal	NN
cord-006229-7yoilsho	1547	40	.	.	.
cord-006229-7yoilsho	1548	1	In	in	IN
cord-006229-7yoilsho	1548	2	the	the	DT
cord-006229-7yoilsho	1548	3	presence	presence	NN
cord-006229-7yoilsho	1548	4	of	of	IN
cord-006229-7yoilsho	1548	5	GRK2	GRK2	NNP
cord-006229-7yoilsho	1548	6	,	,	,
cord-006229-7yoilsho	1548	7	however	however	RB
cord-006229-7yoilsho	1548	8	,	,	,
cord-006229-7yoilsho	1548	9	Gβγ	Gβγ	NNP
cord-006229-7yoilsho	1548	10	changes	change	VBZ
cord-006229-7yoilsho	1548	11	its	-PRON-	PRP$
cord-006229-7yoilsho	1548	12	position	position	NN
cord-006229-7yoilsho	1548	13	relative	relative	JJ
cord-006229-7yoilsho	1548	14	to	to	IN
cord-006229-7yoilsho	1548	15	the	the	DT
cord-006229-7yoilsho	1548	16	µOR	µOR	NNP
cord-006229-7yoilsho	1548	17	in	in	IN
cord-006229-7yoilsho	1548	18	a	a	DT
cord-006229-7yoilsho	1548	19	way	way	NN
cord-006229-7yoilsho	1548	20	that	that	WDT
cord-006229-7yoilsho	1548	21	allows	allow	VBZ
cord-006229-7yoilsho	1548	22	the	the	DT
cord-006229-7yoilsho	1548	23	interaction	interaction	NN
cord-006229-7yoilsho	1548	24	of	of	IN
cord-006229-7yoilsho	1548	25	the	the	DT
cord-006229-7yoilsho	1548	26	GRK2-Gβγ	GRK2-Gβγ	NNP
cord-006229-7yoilsho	1548	27	complex	complex	JJ
cord-006229-7yoilsho	1548	28	with	with	IN
cord-006229-7yoilsho	1548	29	the	the	DT
cord-006229-7yoilsho	1548	30	µOR	µOR	NNP
cord-006229-7yoilsho	1548	31	to	to	TO
cord-006229-7yoilsho	1548	32	be	be	VB
cord-006229-7yoilsho	1548	33	detected	detect	VBN
cord-006229-7yoilsho	1548	34	by	by	IN
cord-006229-7yoilsho	1548	35	FRET	fret	NN
cord-006229-7yoilsho	1548	36	.	.	.
cord-006229-7yoilsho	1549	1	Similarly	similarly	RB
cord-006229-7yoilsho	1549	2	,	,	,
cord-006229-7yoilsho	1549	3	we	-PRON-	PRP
cord-006229-7yoilsho	1549	4	measured	measure	VBD
cord-006229-7yoilsho	1549	5	FRET	fret	NN
cord-006229-7yoilsho	1549	6	between	between	IN
cord-006229-7yoilsho	1549	7	Gβγ	Gβγ	NNP
cord-006229-7yoilsho	1549	8	and	and	CC
cord-006229-7yoilsho	1549	9	the	the	DT
cord-006229-7yoilsho	1549	10	α	α	NNP
cord-006229-7yoilsho	1549	11	2A	2a	CD
cord-006229-7yoilsho	1549	12	-adrenergic	-adrenergic	JJ
cord-006229-7yoilsho	1549	13	receptor	receptor	NN
cord-006229-7yoilsho	1549	14	or	or	CC
cord-006229-7yoilsho	1549	15	the	the	DT
cord-006229-7yoilsho	1549	16	M	M	NNP
cord-006229-7yoilsho	1549	17	3	3	CD
cord-006229-7yoilsho	1549	18	muscarinic	muscarinic	JJ
cord-006229-7yoilsho	1549	19	acetylcholine	acetylcholine	NN
cord-006229-7yoilsho	1549	20	receptor	receptor	NN
cord-006229-7yoilsho	1549	21	in	in	IN
cord-006229-7yoilsho	1549	22	the	the	DT
cord-006229-7yoilsho	1549	23	absence	absence	NN
cord-006229-7yoilsho	1549	24	and	and	CC
cord-006229-7yoilsho	1549	25	presence	presence	NN
cord-006229-7yoilsho	1549	26	of	of	IN
cord-006229-7yoilsho	1549	27	GRK2	GRK2	NNP
cord-006229-7yoilsho	1549	28	and	and	CC
cord-006229-7yoilsho	1549	29	compared	compare	VBD
cord-006229-7yoilsho	1549	30	the	the	DT
cord-006229-7yoilsho	1549	31	kinetics	kinetic	NNS
cord-006229-7yoilsho	1549	32	with	with	IN
cord-006229-7yoilsho	1549	33	the	the	DT
cord-006229-7yoilsho	1549	34	kinetics	kinetic	NNS
cord-006229-7yoilsho	1549	35	of	of	IN
cord-006229-7yoilsho	1549	36	GRK2	GRK2	NNP
cord-006229-7yoilsho	1549	37	binding	bind	VBG
cord-006229-7yoilsho	1549	38	and	and	CC
cord-006229-7yoilsho	1549	39	unbinding	unbind	VBG
cord-006229-7yoilsho	1549	40	to	to	IN
cord-006229-7yoilsho	1549	41	these	these	DT
cord-006229-7yoilsho	1549	42	receptors	receptor	NNS
cord-006229-7yoilsho	1549	43	.	.	.
cord-006229-7yoilsho	1550	1	In	in	IN
cord-006229-7yoilsho	1550	2	both	both	DT
cord-006229-7yoilsho	1550	3	cases	case	NNS
cord-006229-7yoilsho	1550	4	,	,	,
cord-006229-7yoilsho	1550	5	we	-PRON-	PRP
cord-006229-7yoilsho	1550	6	found	find	VBD
cord-006229-7yoilsho	1550	7	that	that	IN
cord-006229-7yoilsho	1550	8	GRK2	GRK2	NNP
cord-006229-7yoilsho	1550	9	and	and	CC
cord-006229-7yoilsho	1550	10	Gβγ	Gβγ	NNP
cord-006229-7yoilsho	1550	11	in	in	IN
cord-006229-7yoilsho	1550	12	the	the	DT
cord-006229-7yoilsho	1550	13	presence	presence	NN
cord-006229-7yoilsho	1550	14	of	of	IN
cord-006229-7yoilsho	1550	15	GRK2	GRK2	NNP
cord-006229-7yoilsho	1550	16	associate	associate	NN
cord-006229-7yoilsho	1550	17	and	and	CC
cord-006229-7yoilsho	1550	18	dissociate	dissociate	VB
cord-006229-7yoilsho	1550	19	from	from	IN
cord-006229-7yoilsho	1550	20	these	these	DT
cord-006229-7yoilsho	1550	21	receptors	receptor	NNS
cord-006229-7yoilsho	1550	22	with	with	IN
cord-006229-7yoilsho	1550	23	comparable	comparable	JJ
cord-006229-7yoilsho	1550	24	kinetics	kinetic	NNS
cord-006229-7yoilsho	1550	25	.	.	.
cord-006229-7yoilsho	1551	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	1551	2	results	result	NNS
cord-006229-7yoilsho	1551	3	suggest	suggest	VBP
cord-006229-7yoilsho	1551	4	that	that	IN
cord-006229-7yoilsho	1551	5	ligand	ligand	NN
cord-006229-7yoilsho	1551	6	efficacy	efficacy	NN
cord-006229-7yoilsho	1551	7	for	for	IN
cord-006229-7yoilsho	1551	8	µORs	µORs	NNP
cord-006229-7yoilsho	1551	9	is	be	VBZ
cord-006229-7yoilsho	1551	10	already	already	RB
cord-006229-7yoilsho	1551	11	apparent	apparent	JJ
cord-006229-7yoilsho	1551	12	on	on	IN
cord-006229-7yoilsho	1551	13	the	the	DT
cord-006229-7yoilsho	1551	14	level	level	NN
cord-006229-7yoilsho	1551	15	of	of	IN
cord-006229-7yoilsho	1551	16	receptor	receptor	NN
cord-006229-7yoilsho	1551	17	-	-	HYPH
cord-006229-7yoilsho	1551	18	GRK	GRK	NNP
cord-006229-7yoilsho	1551	19	interaction	interaction	NN
cord-006229-7yoilsho	1551	20	.	.	.
cord-006229-7yoilsho	1552	1	Institute	Institute	NNP
cord-006229-7yoilsho	1552	2	of	of	IN
cord-006229-7yoilsho	1552	3	Pharmacology	Pharmacology	NNP
cord-006229-7yoilsho	1552	4	,	,	,
cord-006229-7yoilsho	1552	5	University	University	NNP
cord-006229-7yoilsho	1552	6	Medical	Medical	NNP
cord-006229-7yoilsho	1552	7	Center	Center	NNP
cord-006229-7yoilsho	1552	8	Göttingen	Göttingen	NNP
cord-006229-7yoilsho	1552	9	,	,	,
cord-006229-7yoilsho	1552	10	AG	AG	NNP
cord-006229-7yoilsho	1552	11	Lutz	Lutz	NNP
cord-006229-7yoilsho	1552	12	,	,	,
cord-006229-7yoilsho	1552	13	Göttingen	Göttingen	NNP
cord-006229-7yoilsho	1552	14	,	,	,
cord-006229-7yoilsho	1553	1	Germany	Germany	NNP
cord-006229-7yoilsho	1553	2	Introduction	Introduction	NNP
cord-006229-7yoilsho	1553	3	:	:	:
cord-006229-7yoilsho	1554	1	The	the	DT
cord-006229-7yoilsho	1554	2	monomeric	monomeric	JJ
cord-006229-7yoilsho	1554	3	GTPase	GTPase	NNP
cord-006229-7yoilsho	1554	4	RhoA	RhoA	NNP
cord-006229-7yoilsho	1554	5	is	be	VBZ
cord-006229-7yoilsho	1554	6	dysregulated	dysregulate	VBN
cord-006229-7yoilsho	1554	7	in	in	IN
cord-006229-7yoilsho	1554	8	heart	heart	NN
cord-006229-7yoilsho	1554	9	disease	disease	NN
cord-006229-7yoilsho	1554	10	and	and	CC
cord-006229-7yoilsho	1554	11	in	in	IN
cord-006229-7yoilsho	1554	12	vivo	vivo	NN
cord-006229-7yoilsho	1554	13	models	model	NNS
cord-006229-7yoilsho	1554	14	provide	provide	VBP
cord-006229-7yoilsho	1554	15	evidence	evidence	NN
cord-006229-7yoilsho	1554	16	of	of	IN
cord-006229-7yoilsho	1554	17	RhoA	RhoA	NNP
cord-006229-7yoilsho	1554	18	signaling	signal	VBG
cord-006229-7yoilsho	1554	19	being	be	VBG
cord-006229-7yoilsho	1554	20	involved	involve	VBN
cord-006229-7yoilsho	1554	21	in	in	IN
cord-006229-7yoilsho	1554	22	the	the	DT
cord-006229-7yoilsho	1554	23	progression	progression	NN
cord-006229-7yoilsho	1554	24	of	of	IN
cord-006229-7yoilsho	1554	25	cardiac	cardiac	JJ
cord-006229-7yoilsho	1554	26	fibrosis	fibrosis	NN
cord-006229-7yoilsho	1554	27	and	and	CC
cord-006229-7yoilsho	1554	28	hypertrophy	hypertrophy	NN
cord-006229-7yoilsho	1554	29	.	.	.
cord-006229-7yoilsho	1555	1	How	how	WRB
cord-006229-7yoilsho	1555	2	RhoA	RhoA	NNP
cord-006229-7yoilsho	1555	3	is	be	VBZ
cord-006229-7yoilsho	1555	4	regulated	regulate	VBN
cord-006229-7yoilsho	1555	5	within	within	IN
cord-006229-7yoilsho	1555	6	this	this	DT
cord-006229-7yoilsho	1555	7	context	context	NN
cord-006229-7yoilsho	1555	8	on	on	IN
cord-006229-7yoilsho	1555	9	a	a	DT
cord-006229-7yoilsho	1555	10	cellular	cellular	JJ
cord-006229-7yoilsho	1555	11	level	level	NN
cord-006229-7yoilsho	1555	12	is	be	VBZ
cord-006229-7yoilsho	1555	13	not	not	RB
cord-006229-7yoilsho	1555	14	defined	define	VBN
cord-006229-7yoilsho	1555	15	.	.	.
cord-006229-7yoilsho	1556	1	Objective	objective	NN
cord-006229-7yoilsho	1556	2	:	:	:
cord-006229-7yoilsho	1557	1	The	the	DT
cord-006229-7yoilsho	1557	2	goal	goal	NN
cord-006229-7yoilsho	1557	3	of	of	IN
cord-006229-7yoilsho	1557	4	this	this	DT
cord-006229-7yoilsho	1557	5	study	study	NN
cord-006229-7yoilsho	1557	6	was	be	VBD
cord-006229-7yoilsho	1557	7	to	to	TO
cord-006229-7yoilsho	1557	8	analyze	analyze	VB
cord-006229-7yoilsho	1557	9	RhoA	RhoA	NNP
cord-006229-7yoilsho	1557	10	activation	activation	NN
cord-006229-7yoilsho	1557	11	in	in	IN
cord-006229-7yoilsho	1557	12	adult	adult	NN
cord-006229-7yoilsho	1557	13	cardiomyocytes	cardiomyocyte	NNS
cord-006229-7yoilsho	1557	14	(	(	-LRB-
cord-006229-7yoilsho	1557	15	AMCM	AMCM	NNP
cord-006229-7yoilsho	1557	16	)	)	-RRB-
cord-006229-7yoilsho	1557	17	from	from	IN
cord-006229-7yoilsho	1557	18	normal	normal	JJ
cord-006229-7yoilsho	1557	19	and	and	CC
cord-006229-7yoilsho	1557	20	diseased	diseased	JJ
cord-006229-7yoilsho	1557	21	mouse	mouse	NN
cord-006229-7yoilsho	1557	22	hearts	heart	NNS
cord-006229-7yoilsho	1557	23	in	in	IN
cord-006229-7yoilsho	1557	24	response	response	NN
cord-006229-7yoilsho	1557	25	to	to	IN
cord-006229-7yoilsho	1557	26	G	g	NN
cord-006229-7yoilsho	1557	27	protein	protein	NN
cord-006229-7yoilsho	1557	28	-	-	HYPH
cord-006229-7yoilsho	1557	29	coupled	couple	VBN
cord-006229-7yoilsho	1557	30	receptor	receptor	NN
cord-006229-7yoilsho	1557	31	activation	activation	NN
cord-006229-7yoilsho	1557	32	.	.	.
cord-006229-7yoilsho	1558	1	This	this	DT
cord-006229-7yoilsho	1558	2	project	project	NN
cord-006229-7yoilsho	1558	3	also	also	RB
cord-006229-7yoilsho	1558	4	aimed	aim	VBN
cord-006229-7yoilsho	1558	5	at	at	IN
cord-006229-7yoilsho	1558	6	providing	provide	VBG
cord-006229-7yoilsho	1558	7	new	new	JJ
cord-006229-7yoilsho	1558	8	insight	insight	NN
cord-006229-7yoilsho	1558	9	into	into	IN
cord-006229-7yoilsho	1558	10	the	the	DT
cord-006229-7yoilsho	1558	11	dependence	dependence	NN
cord-006229-7yoilsho	1558	12	of	of	IN
cord-006229-7yoilsho	1558	13	RhoA	RhoA	NNP
cord-006229-7yoilsho	1558	14	localization	localization	NN
cord-006229-7yoilsho	1558	15	and	and	CC
cord-006229-7yoilsho	1558	16	activation	activation	NN
cord-006229-7yoilsho	1558	17	on	on	IN
cord-006229-7yoilsho	1558	18	the	the	DT
cord-006229-7yoilsho	1558	19	signaling	signal	VBG
cord-006229-7yoilsho	1558	20	organizing	organize	VBG
cord-006229-7yoilsho	1558	21	caveolae	caveolae	NNP
cord-006229-7yoilsho	1558	22	in	in	IN
cord-006229-7yoilsho	1558	23	neonatal	neonatal	NN
cord-006229-7yoilsho	1558	24	as	as	RB
cord-006229-7yoilsho	1558	25	well	well	RB
cord-006229-7yoilsho	1558	26	as	as	IN
cord-006229-7yoilsho	1558	27	adult	adult	NN
cord-006229-7yoilsho	1558	28	cardiomyocytes	cardiomyocyte	NNS
cord-006229-7yoilsho	1558	29	and	and	CC
cord-006229-7yoilsho	1558	30	engineered	engineer	VBN
cord-006229-7yoilsho	1558	31	heart	heart	NN
cord-006229-7yoilsho	1558	32	muscles	muscle	NNS
cord-006229-7yoilsho	1558	33	.	.	.
cord-006229-7yoilsho	1559	1	Methods	method	NNS
cord-006229-7yoilsho	1559	2	:	:	:
cord-006229-7yoilsho	1559	3	Cardiomyocytes	cardiomyocyte	NNS
cord-006229-7yoilsho	1559	4	from	from	IN
cord-006229-7yoilsho	1559	5	Sham	Sham	NNP
cord-006229-7yoilsho	1559	6	-	-	HYPH
cord-006229-7yoilsho	1559	7	operated	operate	VBN
cord-006229-7yoilsho	1559	8	C57BL/6	C57BL/6	NNP
cord-006229-7yoilsho	1559	9	mice	mouse	NNS
cord-006229-7yoilsho	1559	10	,	,	,
cord-006229-7yoilsho	1559	11	from	from	IN
cord-006229-7yoilsho	1559	12	mice	mouse	NNS
cord-006229-7yoilsho	1559	13	subjected	subject	VBN
cord-006229-7yoilsho	1559	14	to	to	IN
cord-006229-7yoilsho	1559	15	transverse	transverse	JJ
cord-006229-7yoilsho	1559	16	aortic	aortic	JJ
cord-006229-7yoilsho	1559	17	constriction	constriction	NN
cord-006229-7yoilsho	1559	18	(	(	-LRB-
cord-006229-7yoilsho	1559	19	TAC	TAC	NNP
cord-006229-7yoilsho	1559	20	)	)	-RRB-
cord-006229-7yoilsho	1559	21	or	or	CC
cord-006229-7yoilsho	1559	22	from	from	IN
cord-006229-7yoilsho	1559	23	neonatal	neonatal	JJ
cord-006229-7yoilsho	1559	24	rats	rat	NNS
cord-006229-7yoilsho	1559	25	were	be	VBD
cord-006229-7yoilsho	1559	26	either	either	CC
cord-006229-7yoilsho	1559	27	directly	directly	RB
cord-006229-7yoilsho	1559	28	fixed	fix	VBN
cord-006229-7yoilsho	1559	29	after	after	IN
cord-006229-7yoilsho	1559	30	isolation	isolation	NN
cord-006229-7yoilsho	1559	31	or	or	CC
cord-006229-7yoilsho	1559	32	cultured	culture	VBN
cord-006229-7yoilsho	1559	33	in	in	IN
cord-006229-7yoilsho	1559	34	the	the	DT
cord-006229-7yoilsho	1559	35	presence	presence	NN
cord-006229-7yoilsho	1559	36	or	or	CC
cord-006229-7yoilsho	1559	37	absence	absence	NN
cord-006229-7yoilsho	1559	38	of	of	IN
cord-006229-7yoilsho	1559	39	methyl	methyl	NN
cord-006229-7yoilsho	1559	40	-	-	HYPH
cord-006229-7yoilsho	1559	41	b	b	NN
cord-006229-7yoilsho	1559	42	-	-	HYPH
cord-006229-7yoilsho	1559	43	cyclodextrin	cyclodextrin	NN
cord-006229-7yoilsho	1559	44	(	(	-LRB-
cord-006229-7yoilsho	1559	45	MβCD	MβCD	NNP
cord-006229-7yoilsho	1559	46	)	)	-RRB-
cord-006229-7yoilsho	1559	47	.	.	.
cord-006229-7yoilsho	1560	1	For	for	IN
cord-006229-7yoilsho	1560	2	analyses	analysis	NNS
cord-006229-7yoilsho	1560	3	of	of	IN
cord-006229-7yoilsho	1560	4	RhoA	RhoA	NNP
cord-006229-7yoilsho	1560	5	activation	activation	NN
cord-006229-7yoilsho	1560	6	cells	cell	NNS
cord-006229-7yoilsho	1560	7	were	be	VBD
cord-006229-7yoilsho	1560	8	treated	treat	VBN
cord-006229-7yoilsho	1560	9	with	with	IN
cord-006229-7yoilsho	1560	10	endothelin-1	endothelin-1	NNP
cord-006229-7yoilsho	1560	11	(	(	-LRB-
cord-006229-7yoilsho	1560	12	ET-1	ET-1	NNP
cord-006229-7yoilsho	1560	13	)	)	-RRB-
cord-006229-7yoilsho	1560	14	for	for	IN
cord-006229-7yoilsho	1560	15	90	90	CD
cord-006229-7yoilsho	1560	16	sec	sec	NNS
cord-006229-7yoilsho	1560	17	.	.	.
cord-006229-7yoilsho	1561	1	Cells	cell	NNS
cord-006229-7yoilsho	1561	2	were	be	VBD
cord-006229-7yoilsho	1561	3	prepared	prepare	VBN
cord-006229-7yoilsho	1561	4	for	for	IN
cord-006229-7yoilsho	1561	5	immunofluorescence	immunofluorescence	NN
cord-006229-7yoilsho	1561	6	analysis	analysis	NN
cord-006229-7yoilsho	1561	7	or	or	CC
cord-006229-7yoilsho	1561	8	lyzed	lyze	VBN
cord-006229-7yoilsho	1561	9	for	for	IN
cord-006229-7yoilsho	1561	10	immunoblotting	immunoblotte	VBG
cord-006229-7yoilsho	1561	11	.	.	.
cord-006229-7yoilsho	1562	1	Imaging	imaging	NN
cord-006229-7yoilsho	1562	2	was	be	VBD
cord-006229-7yoilsho	1562	3	performed	perform	VBN
cord-006229-7yoilsho	1562	4	using	use	VBG
cord-006229-7yoilsho	1562	5	confocal	confocal	JJ
cord-006229-7yoilsho	1562	6	microscopy	microscopy	NNS
cord-006229-7yoilsho	1562	7	.	.	.
cord-006229-7yoilsho	1563	1	Effects	effect	NNS
cord-006229-7yoilsho	1563	2	of	of	IN
cord-006229-7yoilsho	1563	3	MβCD	MβCD	NNP
cord-006229-7yoilsho	1563	4	were	be	VBD
cord-006229-7yoilsho	1563	5	further	further	RB
cord-006229-7yoilsho	1563	6	studied	study	VBN
cord-006229-7yoilsho	1563	7	in	in	IN
cord-006229-7yoilsho	1563	8	3D	3d	JJ
cord-006229-7yoilsho	1563	9	engineered	engineered	JJ
cord-006229-7yoilsho	1563	10	heart	heart	NN
cord-006229-7yoilsho	1563	11	muscles	muscle	NNS
cord-006229-7yoilsho	1563	12	(	(	-LRB-
cord-006229-7yoilsho	1563	13	EHM	ehm	UH
cord-006229-7yoilsho	1563	14	)	)	-RRB-
cord-006229-7yoilsho	1563	15	made	make	VBN
cord-006229-7yoilsho	1563	16	from	from	IN
cord-006229-7yoilsho	1563	17	total	total	JJ
cord-006229-7yoilsho	1563	18	neonatal	neonatal	JJ
cord-006229-7yoilsho	1563	19	rat	rat	NN
cord-006229-7yoilsho	1563	20	cardiac	cardiac	NN
cord-006229-7yoilsho	1563	21	cells	cell	NNS
cord-006229-7yoilsho	1563	22	.	.	.
cord-006229-7yoilsho	1564	1	The	the	DT
cord-006229-7yoilsho	1564	2	contractile	contractile	JJ
cord-006229-7yoilsho	1564	3	function	function	NN
cord-006229-7yoilsho	1564	4	of	of	IN
cord-006229-7yoilsho	1564	5	EHM	EHM	NNP
cord-006229-7yoilsho	1564	6	was	be	VBD
cord-006229-7yoilsho	1564	7	assessed	assess	VBN
cord-006229-7yoilsho	1564	8	in	in	IN
cord-006229-7yoilsho	1564	9	the	the	DT
cord-006229-7yoilsho	1564	10	organ	organ	NN
cord-006229-7yoilsho	1564	11	bath	bath	NN
cord-006229-7yoilsho	1564	12	and	and	CC
cord-006229-7yoilsho	1564	13	cells	cell	NNS
cord-006229-7yoilsho	1564	14	were	be	VBD
cord-006229-7yoilsho	1564	15	studied	study	VBN
cord-006229-7yoilsho	1564	16	in	in	IN
cord-006229-7yoilsho	1564	17	sections	section	NNS
cord-006229-7yoilsho	1564	18	by	by	IN
cord-006229-7yoilsho	1564	19	immunofluorescence	immunofluorescence	NN
cord-006229-7yoilsho	1564	20	analysis	analysis	NN
cord-006229-7yoilsho	1564	21	.	.	.
cord-006229-7yoilsho	1565	1	Results	result	NNS
cord-006229-7yoilsho	1565	2	:	:	:
cord-006229-7yoilsho	1566	1	In	in	IN
cord-006229-7yoilsho	1566	2	AMCM	AMCM	NNP
cord-006229-7yoilsho	1566	3	from	from	IN
cord-006229-7yoilsho	1566	4	Sham	Sham	NNP
cord-006229-7yoilsho	1566	5	mice	mouse	NNS
cord-006229-7yoilsho	1566	6	active	active	JJ
cord-006229-7yoilsho	1566	7	RhoA	RhoA	NNP
cord-006229-7yoilsho	1566	8	mainly	mainly	RB
cord-006229-7yoilsho	1566	9	localizes	localize	VBZ
cord-006229-7yoilsho	1566	10	at	at	IN
cord-006229-7yoilsho	1566	11	the	the	DT
cord-006229-7yoilsho	1566	12	sarcolemma	sarcolemma	NN
cord-006229-7yoilsho	1566	13	and	and	CC
cord-006229-7yoilsho	1566	14	is	be	VBZ
cord-006229-7yoilsho	1566	15	augmented	augment	VBN
cord-006229-7yoilsho	1566	16	in	in	IN
cord-006229-7yoilsho	1566	17	response	response	NN
cord-006229-7yoilsho	1566	18	to	to	IN
cord-006229-7yoilsho	1566	19	ET-1	ET-1	NNP
cord-006229-7yoilsho	1566	20	treatment	treatment	NN
cord-006229-7yoilsho	1566	21	.	.	.
cord-006229-7yoilsho	1567	1	In	in	IN
cord-006229-7yoilsho	1567	2	TAC	TAC	NNP
cord-006229-7yoilsho	1567	3	-	-	HYPH
cord-006229-7yoilsho	1567	4	AMCM	AMCM	NNP
cord-006229-7yoilsho	1567	5	the	the	DT
cord-006229-7yoilsho	1567	6	basal	basal	NN
cord-006229-7yoilsho	1567	7	level	level	NN
cord-006229-7yoilsho	1567	8	of	of	IN
cord-006229-7yoilsho	1567	9	active	active	JJ
cord-006229-7yoilsho	1567	10	RhoA	RhoA	NNP
cord-006229-7yoilsho	1567	11	is	be	VBZ
cord-006229-7yoilsho	1567	12	increased	increase	VBN
cord-006229-7yoilsho	1567	13	and	and	CC
cord-006229-7yoilsho	1567	14	surprisingly	surprisingly	RB
cord-006229-7yoilsho	1567	15	ET-1	ET-1	NNP
cord-006229-7yoilsho	1567	16	had	have	VBD
cord-006229-7yoilsho	1567	17	no	no	DT
cord-006229-7yoilsho	1567	18	further	further	JJ
cord-006229-7yoilsho	1567	19	effect	effect	NN
cord-006229-7yoilsho	1567	20	.	.	.
cord-006229-7yoilsho	1568	1	Immunoblot	Immunoblot	NNP
cord-006229-7yoilsho	1568	2	analysis	analysis	NN
cord-006229-7yoilsho	1568	3	demonstrated	demonstrate	VBD
cord-006229-7yoilsho	1568	4	that	that	IN
cord-006229-7yoilsho	1568	5	in	in	IN
cord-006229-7yoilsho	1568	6	TAC	TAC	NNP
cord-006229-7yoilsho	1568	7	-	-	HYPH
cord-006229-7yoilsho	1568	8	AMCM	AMCM	NNP
cord-006229-7yoilsho	1568	9	RhoA	RhoA	NNP
cord-006229-7yoilsho	1568	10	expression	expression	NN
cord-006229-7yoilsho	1568	11	was	be	VBD
cord-006229-7yoilsho	1568	12	per	per	IN
cord-006229-7yoilsho	1568	13	se	se	FW
cord-006229-7yoilsho	1568	14	higher	higher	RBR
cord-006229-7yoilsho	1568	15	and	and	CC
cord-006229-7yoilsho	1568	16	the	the	DT
cord-006229-7yoilsho	1568	17	major	major	JJ
cord-006229-7yoilsho	1568	18	caveolae	caveolae	NN
cord-006229-7yoilsho	1568	19	protein	protein	NN
cord-006229-7yoilsho	1568	20	caveolin-3	caveolin-3	NNP
cord-006229-7yoilsho	1568	21	was	be	VBD
cord-006229-7yoilsho	1568	22	reduced	reduce	VBN
cord-006229-7yoilsho	1568	23	.	.	.
cord-006229-7yoilsho	1569	1	To	to	TO
cord-006229-7yoilsho	1569	2	test	test	VB
cord-006229-7yoilsho	1569	3	the	the	DT
cord-006229-7yoilsho	1569	4	influence	influence	NN
cord-006229-7yoilsho	1569	5	of	of	IN
cord-006229-7yoilsho	1569	6	caveolae	caveolae	NNP
cord-006229-7yoilsho	1569	7	on	on	IN
cord-006229-7yoilsho	1569	8	RhoA	RhoA	NNP
cord-006229-7yoilsho	1569	9	activation	activation	NN
cord-006229-7yoilsho	1569	10	and	and	CC
cord-006229-7yoilsho	1569	11	expression	expression	NN
cord-006229-7yoilsho	1569	12	,	,	,
cord-006229-7yoilsho	1569	13	we	-PRON-	PRP
cord-006229-7yoilsho	1569	14	treated	treat	VBD
cord-006229-7yoilsho	1569	15	NRCM	NRCM	NNP
cord-006229-7yoilsho	1569	16	with	with	IN
cord-006229-7yoilsho	1569	17	MβCD	MβCD	NNP
cord-006229-7yoilsho	1569	18	and	and	CC
cord-006229-7yoilsho	1569	19	found	find	VBD
cord-006229-7yoilsho	1569	20	the	the	DT
cord-006229-7yoilsho	1569	21	expression	expression	NN
cord-006229-7yoilsho	1569	22	of	of	IN
cord-006229-7yoilsho	1569	23	RhoA	RhoA	NNP
cord-006229-7yoilsho	1569	24	as	as	RB
cord-006229-7yoilsho	1569	25	well	well	RB
cord-006229-7yoilsho	1569	26	as	as	IN
cord-006229-7yoilsho	1569	27	of	of	IN
cord-006229-7yoilsho	1569	28	RhoA	RhoA	NNP
cord-006229-7yoilsho	1569	29	target	target	NN
cord-006229-7yoilsho	1569	30	genes	gene	NNS
cord-006229-7yoilsho	1569	31	CCN1	CCN1	NNP
cord-006229-7yoilsho	1569	32	and	and	CC
cord-006229-7yoilsho	1569	33	CCN2	CCN2	NNP
cord-006229-7yoilsho	1569	34	to	to	TO
cord-006229-7yoilsho	1569	35	be	be	VB
cord-006229-7yoilsho	1569	36	moderately	moderately	RB
cord-006229-7yoilsho	1569	37	up	up	RB
cord-006229-7yoilsho	1569	38	-	-	HYPH
cord-006229-7yoilsho	1569	39	regulated	regulate	VBN
cord-006229-7yoilsho	1569	40	after	after	IN
cord-006229-7yoilsho	1569	41	24h	24h	NNS
cord-006229-7yoilsho	1569	42	.	.	.
cord-006229-7yoilsho	1570	1	In	in	IN
cord-006229-7yoilsho	1570	2	addition	addition	NN
cord-006229-7yoilsho	1570	3	,	,	,
cord-006229-7yoilsho	1570	4	an	an	DT
cord-006229-7yoilsho	1570	5	intensified	intensify	VBN
cord-006229-7yoilsho	1570	6	longitudinal	longitudinal	JJ
cord-006229-7yoilsho	1570	7	alignment	alignment	NN
cord-006229-7yoilsho	1570	8	of	of	IN
cord-006229-7yoilsho	1570	9	sarcomeric	sarcomeric	JJ
cord-006229-7yoilsho	1570	10	actin	actin	NN
cord-006229-7yoilsho	1570	11	fibers	fiber	NNS
cord-006229-7yoilsho	1570	12	was	be	VBD
cord-006229-7yoilsho	1570	13	detectable	detectable	JJ
cord-006229-7yoilsho	1570	14	,	,	,
cord-006229-7yoilsho	1570	15	which	which	WDT
cord-006229-7yoilsho	1570	16	could	could	MD
cord-006229-7yoilsho	1570	17	also	also	RB
cord-006229-7yoilsho	1570	18	be	be	VB
cord-006229-7yoilsho	1570	19	seen	see	VBN
cord-006229-7yoilsho	1570	20	in	in	IN
cord-006229-7yoilsho	1570	21	MβCD	mβcd	NN
cord-006229-7yoilsho	1570	22	-	-	HYPH
cord-006229-7yoilsho	1570	23	treated	treat	VBN
cord-006229-7yoilsho	1570	24	EHM	EHM	NNP
cord-006229-7yoilsho	1570	25	.	.	.
cord-006229-7yoilsho	1571	1	However	however	RB
cord-006229-7yoilsho	1571	2	,	,	,
cord-006229-7yoilsho	1571	3	MβCD	MβCD	NNP
cord-006229-7yoilsho	1571	4	had	have	VBD
cord-006229-7yoilsho	1571	5	no	no	DT
cord-006229-7yoilsho	1571	6	effect	effect	NN
cord-006229-7yoilsho	1571	7	on	on	IN
cord-006229-7yoilsho	1571	8	EHM	EHM	NNP
cord-006229-7yoilsho	1571	9	twitch	twitch	VB
cord-006229-7yoilsho	1571	10	tension	tension	NN
cord-006229-7yoilsho	1571	11	but	but	CC
cord-006229-7yoilsho	1571	12	increased	increase	VBD
cord-006229-7yoilsho	1571	13	the	the	DT
cord-006229-7yoilsho	1571	14	resting	rest	VBG
cord-006229-7yoilsho	1571	15	tension	tension	NN
cord-006229-7yoilsho	1571	16	compared	compare	VBN
cord-006229-7yoilsho	1571	17	to	to	IN
cord-006229-7yoilsho	1571	18	control	control	NN
cord-006229-7yoilsho	1571	19	.	.	.
cord-006229-7yoilsho	1572	1	We	-PRON-	PRP
cord-006229-7yoilsho	1572	2	further	further	RB
cord-006229-7yoilsho	1572	3	treated	treat	VBD
cord-006229-7yoilsho	1572	4	AMCM	AMCM	NNP
cord-006229-7yoilsho	1572	5	with	with	IN
cord-006229-7yoilsho	1572	6	MβCD	MβCD	NNP
cord-006229-7yoilsho	1572	7	and	and	CC
cord-006229-7yoilsho	1572	8	found	find	VBD
cord-006229-7yoilsho	1572	9	RhoA	RhoA	NNP
cord-006229-7yoilsho	1572	10	expression	expression	NN
cord-006229-7yoilsho	1572	11	to	to	TO
cord-006229-7yoilsho	1572	12	be	be	VB
cord-006229-7yoilsho	1572	13	increased	increase	VBN
cord-006229-7yoilsho	1572	14	and	and	CC
cord-006229-7yoilsho	1572	15	its	-PRON-	PRP$
cord-006229-7yoilsho	1572	16	activity	activity	NN
cord-006229-7yoilsho	1572	17	less	less	RBR
cord-006229-7yoilsho	1572	18	sensitive	sensitive	JJ
cord-006229-7yoilsho	1572	19	to	to	IN
cord-006229-7yoilsho	1572	20	ET-1	ET-1	NNP
cord-006229-7yoilsho	1572	21	treatment	treatment	NN
cord-006229-7yoilsho	1572	22	.	.	.
cord-006229-7yoilsho	1573	1	Finally	finally	RB
cord-006229-7yoilsho	1573	2	,	,	,
cord-006229-7yoilsho	1573	3	we	-PRON-	PRP
cord-006229-7yoilsho	1573	4	could	could	MD
cord-006229-7yoilsho	1573	5	show	show	VB
cord-006229-7yoilsho	1573	6	that	that	IN
cord-006229-7yoilsho	1573	7	the	the	DT
cord-006229-7yoilsho	1573	8	perinuclear	perinuclear	NNP
cord-006229-7yoilsho	1573	9	localization	localization	NN
cord-006229-7yoilsho	1573	10	of	of	IN
cord-006229-7yoilsho	1573	11	Cav3	Cav3	NNP
cord-006229-7yoilsho	1573	12	and	and	CC
cord-006229-7yoilsho	1573	13	RhoA	RhoA	NNP
cord-006229-7yoilsho	1573	14	was	be	VBD
cord-006229-7yoilsho	1573	15	strongly	strongly	RB
cord-006229-7yoilsho	1573	16	reduced	reduce	VBN
cord-006229-7yoilsho	1573	17	after	after	IN
cord-006229-7yoilsho	1573	18	MβCD	MβCD	NNP
cord-006229-7yoilsho	1573	19	treatment	treatment	NN
cord-006229-7yoilsho	1573	20	.	.	.
cord-006229-7yoilsho	1574	1	Whereas	whereas	IN
cord-006229-7yoilsho	1574	2	G	g	NN
cord-006229-7yoilsho	1574	3	-	-	HYPH
cord-006229-7yoilsho	1574	4	protein	protein	NN
cord-006229-7yoilsho	1574	5	coupled	coupled	JJ
cord-006229-7yoilsho	1574	6	receptors	receptor	NNS
cord-006229-7yoilsho	1574	7	(	(	-LRB-
cord-006229-7yoilsho	1574	8	GPCRs	gpcr	NNS
cord-006229-7yoilsho	1574	9	)	)	-RRB-
cord-006229-7yoilsho	1574	10	have	have	VBP
cord-006229-7yoilsho	1574	11	been	be	VBN
cord-006229-7yoilsho	1574	12	long	long	RB
cord-006229-7yoilsho	1574	13	believed	believe	VBN
cord-006229-7yoilsho	1574	14	to	to	TO
cord-006229-7yoilsho	1574	15	signal	signal	VB
cord-006229-7yoilsho	1574	16	through	through	IN
cord-006229-7yoilsho	1574	17	cyclic	cyclic	JJ
cord-006229-7yoilsho	1574	18	AMP	amp	NN
cord-006229-7yoilsho	1574	19	only	only	RB
cord-006229-7yoilsho	1574	20	at	at	IN
cord-006229-7yoilsho	1574	21	cell	cell	NN
cord-006229-7yoilsho	1574	22	surface	surface	NN
cord-006229-7yoilsho	1574	23	,	,	,
cord-006229-7yoilsho	1574	24	our	-PRON-	PRP$
cord-006229-7yoilsho	1574	25	group	group	NN
cord-006229-7yoilsho	1574	26	has	have	VBZ
cord-006229-7yoilsho	1574	27	previously	previously	RB
cord-006229-7yoilsho	1574	28	shown	show	VBN
cord-006229-7yoilsho	1574	29	that	that	IN
cord-006229-7yoilsho	1574	30	GPCRs	gpcr	NNS
cord-006229-7yoilsho	1574	31	not	not	RB
cord-006229-7yoilsho	1574	32	only	only	RB
cord-006229-7yoilsho	1574	33	signal	signal	VB
cord-006229-7yoilsho	1574	34	at	at	IN
cord-006229-7yoilsho	1574	35	the	the	DT
cord-006229-7yoilsho	1574	36	cell	cell	NN
cord-006229-7yoilsho	1574	37	surface	surface	NN
cord-006229-7yoilsho	1574	38	but	but	CC
cord-006229-7yoilsho	1574	39	can	can	MD
cord-006229-7yoilsho	1574	40	also	also	RB
cord-006229-7yoilsho	1574	41	continue	continue	VB
cord-006229-7yoilsho	1574	42	doing	do	VBG
cord-006229-7yoilsho	1574	43	so	so	RB
cord-006229-7yoilsho	1574	44	once	once	RB
cord-006229-7yoilsho	1574	45	internalized	internalize	VBN
cord-006229-7yoilsho	1574	46	together	together	RB
cord-006229-7yoilsho	1574	47	with	with	IN
cord-006229-7yoilsho	1574	48	their	-PRON-	PRP$
cord-006229-7yoilsho	1574	49	ligands	ligand	NNS
cord-006229-7yoilsho	1574	50	,	,	,
cord-006229-7yoilsho	1574	51	leading	lead	VBG
cord-006229-7yoilsho	1574	52	to	to	IN
cord-006229-7yoilsho	1574	53	persistent	persistent	JJ
cord-006229-7yoilsho	1574	54	cAMP	camp	NN
cord-006229-7yoilsho	1574	55	production	production	NN
cord-006229-7yoilsho	1574	56	(	(	-LRB-
cord-006229-7yoilsho	1574	57	1	1	CD
cord-006229-7yoilsho	1574	58	)	)	-RRB-
cord-006229-7yoilsho	1574	59	.	.	.
cord-006229-7yoilsho	1575	1	This	this	DT
cord-006229-7yoilsho	1575	2	phenomenon	phenomenon	NN
cord-006229-7yoilsho	1575	3	,	,	,
cord-006229-7yoilsho	1575	4	which	which	WDT
cord-006229-7yoilsho	1575	5	we	-PRON-	PRP
cord-006229-7yoilsho	1575	6	originally	originally	RB
cord-006229-7yoilsho	1575	7	described	describe	VBD
cord-006229-7yoilsho	1575	8	for	for	IN
cord-006229-7yoilsho	1575	9	the	the	DT
cord-006229-7yoilsho	1575	10	thyroid	thyroid	JJ
cord-006229-7yoilsho	1575	11	stimulating	stimulate	VBG
cord-006229-7yoilsho	1575	12	hormone	hormone	NN
cord-006229-7yoilsho	1575	13	receptor	receptor	NN
cord-006229-7yoilsho	1575	14	(	(	-LRB-
cord-006229-7yoilsho	1575	15	TSHR	TSHR	NNP
cord-006229-7yoilsho	1575	16	)	)	-RRB-
cord-006229-7yoilsho	1575	17	in	in	IN
cord-006229-7yoilsho	1575	18	thyroid	thyroid	NN
cord-006229-7yoilsho	1575	19	cells	cell	NNS
cord-006229-7yoilsho	1575	20	,	,	,
cord-006229-7yoilsho	1575	21	has	have	VBZ
cord-006229-7yoilsho	1575	22	been	be	VBN
cord-006229-7yoilsho	1575	23	observed	observe	VBN
cord-006229-7yoilsho	1575	24	also	also	RB
cord-006229-7yoilsho	1575	25	for	for	IN
cord-006229-7yoilsho	1575	26	other	other	JJ
cord-006229-7yoilsho	1575	27	GPCRs	gpcr	NNS
cord-006229-7yoilsho	1575	28	(	(	-LRB-
cord-006229-7yoilsho	1575	29	2	2	CD
cord-006229-7yoilsho	1575	30	)	)	-RRB-
cord-006229-7yoilsho	1575	31	(	(	-LRB-
cord-006229-7yoilsho	1575	32	3	3	LS
cord-006229-7yoilsho	1575	33	)	)	-RRB-
cord-006229-7yoilsho	1575	34	(	(	-LRB-
cord-006229-7yoilsho	1575	35	4	4	LS
cord-006229-7yoilsho	1575	36	)	)	-RRB-
cord-006229-7yoilsho	1575	37	.	.	.
cord-006229-7yoilsho	1576	1	However	however	RB
cord-006229-7yoilsho	1576	2	,	,	,
cord-006229-7yoilsho	1576	3	the	the	DT
cord-006229-7yoilsho	1576	4	intracellular	intracellular	JJ
cord-006229-7yoilsho	1576	5	compartment	compartment	NN
cord-006229-7yoilsho	1576	6	responsible	responsible	JJ
cord-006229-7yoilsho	1576	7	for	for	IN
cord-006229-7yoilsho	1576	8	such	such	JJ
cord-006229-7yoilsho	1576	9	persistent	persistent	JJ
cord-006229-7yoilsho	1576	10	signaling	signaling	NN
cord-006229-7yoilsho	1576	11	was	be	VBD
cord-006229-7yoilsho	1576	12	insufficiently	insufficiently	RB
cord-006229-7yoilsho	1576	13	characterized	characterize	VBN
cord-006229-7yoilsho	1576	14	.	.	.
cord-006229-7yoilsho	1577	1	The	the	DT
cord-006229-7yoilsho	1577	2	aim	aim	NN
cord-006229-7yoilsho	1577	3	of	of	IN
cord-006229-7yoilsho	1577	4	this	this	DT
cord-006229-7yoilsho	1577	5	study	study	NN
cord-006229-7yoilsho	1577	6	was	be	VBD
cord-006229-7yoilsho	1577	7	to	to	TO
cord-006229-7yoilsho	1577	8	follow	follow	VB
cord-006229-7yoilsho	1577	9	by	by	IN
cord-006229-7yoilsho	1577	10	live	live	JJ
cord-006229-7yoilsho	1577	11	-	-	HYPH
cord-006229-7yoilsho	1577	12	cell	cell	NN
cord-006229-7yoilsho	1577	13	imaging	image	VBG
cord-006229-7yoilsho	1577	14	the	the	DT
cord-006229-7yoilsho	1577	15	internalization	internalization	NN
cord-006229-7yoilsho	1577	16	and	and	CC
cord-006229-7yoilsho	1577	17	trafficking	trafficking	NN
cord-006229-7yoilsho	1577	18	of	of	IN
cord-006229-7yoilsho	1577	19	TSHR	TSHR	NNP
cord-006229-7yoilsho	1577	20	,	,	,
cord-006229-7yoilsho	1577	21	TSH	tsh	NN
cord-006229-7yoilsho	1577	22	and	and	CC
cord-006229-7yoilsho	1577	23	effector	effector	NN
cord-006229-7yoilsho	1577	24	proteins	protein	NNS
cord-006229-7yoilsho	1577	25	in	in	IN
cord-006229-7yoilsho	1577	26	thyroid	thyroid	NN
cord-006229-7yoilsho	1577	27	cells	cell	NNS
cord-006229-7yoilsho	1577	28	.	.	.
cord-006229-7yoilsho	1578	1	Mouse	mouse	NN
cord-006229-7yoilsho	1578	2	primary	primary	JJ
cord-006229-7yoilsho	1578	3	thyroid	thyroid	NN
cord-006229-7yoilsho	1578	4	cells	cell	NNS
cord-006229-7yoilsho	1578	5	were	be	VBD
cord-006229-7yoilsho	1578	6	transfected	transfecte	VBN
cord-006229-7yoilsho	1578	7	with	with	IN
cord-006229-7yoilsho	1578	8	fluorescent	fluorescent	NN
cord-006229-7yoilsho	1578	9	-	-	HYPH
cord-006229-7yoilsho	1578	10	protein	protein	NN
cord-006229-7yoilsho	1578	11	tagged	tagged	NNP
cord-006229-7yoilsho	1578	12	TSHR	TSHR	NNP
cord-006229-7yoilsho	1578	13	,	,	,
cord-006229-7yoilsho	1578	14	G	g	NN
cord-006229-7yoilsho	1578	15	-	-	HYPH
cord-006229-7yoilsho	1578	16	proteins	protein	NNS
cord-006229-7yoilsho	1578	17	,	,	,
cord-006229-7yoilsho	1578	18	nanobody	nanobody	NN
cord-006229-7yoilsho	1578	19	specific	specific	JJ
cord-006229-7yoilsho	1578	20	for	for	IN
cord-006229-7yoilsho	1578	21	active	active	JJ
cord-006229-7yoilsho	1578	22	G	g	NN
cord-006229-7yoilsho	1578	23	-	-	HYPH
cord-006229-7yoilsho	1578	24	proteins	protein	NNS
cord-006229-7yoilsho	1578	25	and/or	and/or	CC
cord-006229-7yoilsho	1578	26	subcellular	subcellular	JJ
cord-006229-7yoilsho	1578	27	markers	marker	NNS
cord-006229-7yoilsho	1578	28	by	by	IN
cord-006229-7yoilsho	1578	29	electroporation	electroporation	NN
cord-006229-7yoilsho	1578	30	,	,	,
cord-006229-7yoilsho	1578	31	stimulated	stimulate	VBN
cord-006229-7yoilsho	1578	32	with	with	IN
cord-006229-7yoilsho	1578	33	fluorescently	fluorescently	RB
cord-006229-7yoilsho	1578	34	labeled	label	VBN
cord-006229-7yoilsho	1578	35	TSH	TSH	NNP
cord-006229-7yoilsho	1578	36	and	and	CC
cord-006229-7yoilsho	1578	37	visualized	visualize	VBN
cord-006229-7yoilsho	1578	38	using	use	VBG
cord-006229-7yoilsho	1578	39	highly	highly	RB
cord-006229-7yoilsho	1578	40	inclined	incline	VBN
cord-006229-7yoilsho	1578	41	thin	thin	JJ
cord-006229-7yoilsho	1578	42	illumination	illumination	NN
cord-006229-7yoilsho	1578	43	(	(	-LRB-
cord-006229-7yoilsho	1578	44	HILO	HILO	NNP
cord-006229-7yoilsho	1578	45	)	)	-RRB-
cord-006229-7yoilsho	1578	46	microscopy	microscopy	NNP
cord-006229-7yoilsho	1578	47	.	.	.
cord-006229-7yoilsho	1579	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	1579	2	results	result	NNS
cord-006229-7yoilsho	1579	3	suggest	suggest	VBP
cord-006229-7yoilsho	1579	4	that	that	IN
cord-006229-7yoilsho	1579	5	TSH	TSH	NNP
cord-006229-7yoilsho	1579	6	is	be	VBZ
cord-006229-7yoilsho	1579	7	internalized	internalize	VBN
cord-006229-7yoilsho	1579	8	in	in	IN
cord-006229-7yoilsho	1579	9	complex	complex	NN
cord-006229-7yoilsho	1579	10	with	with	IN
cord-006229-7yoilsho	1579	11	its	-PRON-	PRP$
cord-006229-7yoilsho	1579	12	receptor	receptor	NN
cord-006229-7yoilsho	1579	13	and	and	CC
cord-006229-7yoilsho	1579	14	they	-PRON-	PRP
cord-006229-7yoilsho	1579	15	traffic	traffic	VBP
cord-006229-7yoilsho	1579	16	retrogradely	retrogradely	RB
cord-006229-7yoilsho	1579	17	via	via	IN
cord-006229-7yoilsho	1579	18	the	the	DT
cord-006229-7yoilsho	1579	19	Trans	Trans	NNP
cord-006229-7yoilsho	1579	20	Golgi	Golgi	NNP
cord-006229-7yoilsho	1579	21	network	network	NN
cord-006229-7yoilsho	1579	22	(	(	-LRB-
cord-006229-7yoilsho	1579	23	TGN	TGN	NNP
cord-006229-7yoilsho	1579	24	)	)	-RRB-
cord-006229-7yoilsho	1579	25	.	.	.
cord-006229-7yoilsho	1580	1	While	while	IN
cord-006229-7yoilsho	1580	2	we	-PRON-	PRP
cord-006229-7yoilsho	1580	3	could	could	MD
cord-006229-7yoilsho	1580	4	not	not	RB
cord-006229-7yoilsho	1580	5	find	find	VB
cord-006229-7yoilsho	1580	6	any	any	DT
cord-006229-7yoilsho	1580	7	evidence	evidence	NN
cord-006229-7yoilsho	1580	8	of	of	IN
cord-006229-7yoilsho	1580	9	internalized	internalize	VBN
cord-006229-7yoilsho	1580	10	TSH	TSH	NNP
cord-006229-7yoilsho	1580	11	/	/	SYM
cord-006229-7yoilsho	1580	12	TSHR	TSHR	NNP
cord-006229-7yoilsho	1580	13	complexes	complex	NNS
cord-006229-7yoilsho	1580	14	activating	activate	VBG
cord-006229-7yoilsho	1580	15	G	g	NN
cord-006229-7yoilsho	1580	16	-	-	HYPH
cord-006229-7yoilsho	1580	17	proteins	protein	NNS
cord-006229-7yoilsho	1580	18	in	in	IN
cord-006229-7yoilsho	1580	19	early	early	JJ
cord-006229-7yoilsho	1580	20	endosomes	endosome	NNS
cord-006229-7yoilsho	1580	21	,	,	,
cord-006229-7yoilsho	1580	22	we	-PRON-	PRP
cord-006229-7yoilsho	1580	23	show	show	VBP
cord-006229-7yoilsho	1580	24	that	that	IN
cord-006229-7yoilsho	1580	25	TSH	TSH	NNP
cord-006229-7yoilsho	1580	26	/	/	SYM
cord-006229-7yoilsho	1580	27	TSHR	TSHR	NNP
cord-006229-7yoilsho	1580	28	complexes	complex	NNS
cord-006229-7yoilsho	1580	29	meet	meet	VBP
cord-006229-7yoilsho	1580	30	the	the	DT
cord-006229-7yoilsho	1580	31	intracellular	intracellular	JJ
cord-006229-7yoilsho	1580	32	pool	pool	NN
cord-006229-7yoilsho	1580	33	of	of	IN
cord-006229-7yoilsho	1580	34	Gαs	Gαs	NNP
cord-006229-7yoilsho	1580	35	in	in	IN
cord-006229-7yoilsho	1580	36	the	the	DT
cord-006229-7yoilsho	1580	37	TGN	TGN	NNP
cord-006229-7yoilsho	1580	38	and	and	CC
cord-006229-7yoilsho	1580	39	activate	activate	VB
cord-006229-7yoilsho	1580	40	it	-PRON-	PRP
cord-006229-7yoilsho	1580	41	,	,	,
cord-006229-7yoilsho	1580	42	as	as	IN
cord-006229-7yoilsho	1580	43	visualized	visualize	VBN
cord-006229-7yoilsho	1580	44	in	in	IN
cord-006229-7yoilsho	1580	45	real	real	JJ
cord-006229-7yoilsho	1580	46	-	-	HYPH
cord-006229-7yoilsho	1580	47	time	time	NN
cord-006229-7yoilsho	1580	48	by	by	IN
cord-006229-7yoilsho	1580	49	a	a	DT
cord-006229-7yoilsho	1580	50	nanobody	nanobody	NN
cord-006229-7yoilsho	1580	51	specific	specific	JJ
cord-006229-7yoilsho	1580	52	for	for	IN
cord-006229-7yoilsho	1580	53	active	active	JJ
cord-006229-7yoilsho	1580	54	Gαs	Gαs	NNP
cord-006229-7yoilsho	1580	55	.	.	.
cord-006229-7yoilsho	1581	1	Upon	upon	IN
cord-006229-7yoilsho	1581	2	acute	acute	JJ
cord-006229-7yoilsho	1581	3	Brefeldin	Brefeldin	NNP
cord-006229-7yoilsho	1581	4	A	A	NNP
cord-006229-7yoilsho	1581	5	-	-	HYPH
cord-006229-7yoilsho	1581	6	induced	induce	VBN
cord-006229-7yoilsho	1581	7	Golgi	Golgi	NNP
cord-006229-7yoilsho	1581	8	collapse	collapse	NN
cord-006229-7yoilsho	1581	9	,	,	,
cord-006229-7yoilsho	1581	10	the	the	DT
cord-006229-7yoilsho	1581	11	retrograde	retrograde	JJ
cord-006229-7yoilsho	1581	12	trafficking	trafficking	NN
cord-006229-7yoilsho	1581	13	of	of	IN
cord-006229-7yoilsho	1581	14	TSH	TSH	NNP
cord-006229-7yoilsho	1581	15	/	/	SYM
cord-006229-7yoilsho	1581	16	TSHR	TSHR	NNP
cord-006229-7yoilsho	1581	17	via	via	IN
cord-006229-7yoilsho	1581	18	TGN	TGN	NNP
cord-006229-7yoilsho	1581	19	is	be	VBZ
cord-006229-7yoilsho	1581	20	hindered	hinder	VBN
cord-006229-7yoilsho	1581	21	.	.	.
cord-006229-7yoilsho	1582	1	Bulk	Bulk	NNP
cord-006229-7yoilsho	1582	2	TSH	TSH	NNP
cord-006229-7yoilsho	1582	3	stimulations	stimulation	NNS
cord-006229-7yoilsho	1582	4	in	in	IN
cord-006229-7yoilsho	1582	5	primary	primary	JJ
cord-006229-7yoilsho	1582	6	mouse	mouse	NN
cord-006229-7yoilsho	1582	7	thyroid	thyroid	NN
cord-006229-7yoilsho	1582	8	cells	cell	NNS
cord-006229-7yoilsho	1582	9	isolated	isolate	VBN
cord-006229-7yoilsho	1582	10	from	from	IN
cord-006229-7yoilsho	1582	11	transgenic	transgenic	JJ
cord-006229-7yoilsho	1582	12	mice	mouse	NNS
cord-006229-7yoilsho	1582	13	expressing	express	VBG
cord-006229-7yoilsho	1582	14	the	the	DT
cord-006229-7yoilsho	1582	15	cAMP	camp	NN
cord-006229-7yoilsho	1582	16	sensor	sensor	NN
cord-006229-7yoilsho	1582	17	,	,	,
cord-006229-7yoilsho	1582	18	Epac1-camps	Epac1-camps	NNP
cord-006229-7yoilsho	1582	19	,	,	,
cord-006229-7yoilsho	1582	20	also	also	RB
cord-006229-7yoilsho	1582	21	show	show	VBP
cord-006229-7yoilsho	1582	22	a	a	DT
cord-006229-7yoilsho	1582	23	significantly	significantly	RB
cord-006229-7yoilsho	1582	24	reduced	reduce	VBN
cord-006229-7yoilsho	1582	25	cAMP	camp	NN
cord-006229-7yoilsho	1582	26	production	production	NN
cord-006229-7yoilsho	1582	27	in	in	IN
cord-006229-7yoilsho	1582	28	the	the	DT
cord-006229-7yoilsho	1582	29	presence	presence	NN
cord-006229-7yoilsho	1582	30	of	of	IN
cord-006229-7yoilsho	1582	31	Brefeldin	Brefeldin	NNP
cord-006229-7yoilsho	1582	32	-	-	HYPH
cord-006229-7yoilsho	1582	33	A.	A.	NNP
cord-006229-7yoilsho	1583	1	These	these	DT
cord-006229-7yoilsho	1583	2	data	datum	NNS
cord-006229-7yoilsho	1583	3	provide	provide	VBP
cord-006229-7yoilsho	1583	4	evidence	evidence	NN
cord-006229-7yoilsho	1583	5	that	that	IN
cord-006229-7yoilsho	1583	6	internalized	internalize	VBD
cord-006229-7yoilsho	1583	7	TSH	TSH	NNP
cord-006229-7yoilsho	1583	8	/	/	SYM
cord-006229-7yoilsho	1583	9	TSHR	TSHR	NNP
cord-006229-7yoilsho	1583	10	complexes	complex	NNS
cord-006229-7yoilsho	1583	11	meet	meet	VBP
cord-006229-7yoilsho	1583	12	and	and	CC
cord-006229-7yoilsho	1583	13	activate	activate	VBP
cord-006229-7yoilsho	1583	14	G	g	NN
cord-006229-7yoilsho	1583	15	-	-	HYPH
cord-006229-7yoilsho	1583	16	proteins	protein	NNS
cord-006229-7yoilsho	1583	17	at	at	IN
cord-006229-7yoilsho	1583	18	the	the	DT
cord-006229-7yoilsho	1583	19	TGN	TGN	NNP
cord-006229-7yoilsho	1583	20	,	,	,
cord-006229-7yoilsho	1583	21	which	which	WDT
cord-006229-7yoilsho	1583	22	might	may	MD
cord-006229-7yoilsho	1583	23	serve	serve	VB
cord-006229-7yoilsho	1583	24	as	as	IN
cord-006229-7yoilsho	1583	25	the	the	DT
cord-006229-7yoilsho	1583	26	main	main	JJ
cord-006229-7yoilsho	1583	27	platform	platform	NN
cord-006229-7yoilsho	1583	28	of	of	IN
cord-006229-7yoilsho	1583	29	persistent	persistent	JJ
cord-006229-7yoilsho	1583	30	cAMP	camp	NN
cord-006229-7yoilsho	1583	31	signaling	signal	VBG
cord-006229-7yoilsho	1583	32	after	after	IN
cord-006229-7yoilsho	1583	33	receptor	receptor	NN
cord-006229-7yoilsho	1583	34	internalization	internalization	NN
cord-006229-7yoilsho	1583	35	.	.	.
cord-006229-7yoilsho	1584	1	Objective	objective	NN
cord-006229-7yoilsho	1584	2	:	:	:
cord-006229-7yoilsho	1585	1	Sphingosine	Sphingosine	NNP
cord-006229-7yoilsho	1585	2	1-phosphate	1-phosphate	NNP
cord-006229-7yoilsho	1585	3	(	(	-LRB-
cord-006229-7yoilsho	1585	4	S1P	s1p	NN
cord-006229-7yoilsho	1585	5	)	)	-RRB-
cord-006229-7yoilsho	1585	6	is	be	VBZ
cord-006229-7yoilsho	1585	7	generated	generate	VBN
cord-006229-7yoilsho	1585	8	by	by	IN
cord-006229-7yoilsho	1585	9	sphingosine	sphingosine	NNP
cord-006229-7yoilsho	1585	10	kinase	kinase	NNP
cord-006229-7yoilsho	1585	11	(	(	-LRB-
cord-006229-7yoilsho	1585	12	SK)-1	sk)-1	NN
cord-006229-7yoilsho	1585	13	and	and	CC
cord-006229-7yoilsho	1585	14	-2	-2	NNP
cord-006229-7yoilsho	1585	15	and	and	CC
cord-006229-7yoilsho	1585	16	acts	act	VBZ
cord-006229-7yoilsho	1585	17	mainly	mainly	RB
cord-006229-7yoilsho	1585	18	as	as	IN
cord-006229-7yoilsho	1585	19	an	an	DT
cord-006229-7yoilsho	1585	20	extracellular	extracellular	JJ
cord-006229-7yoilsho	1585	21	ligand	ligand	NN
cord-006229-7yoilsho	1585	22	at	at	IN
cord-006229-7yoilsho	1585	23	five	five	CD
cord-006229-7yoilsho	1585	24	specific	specific	JJ
cord-006229-7yoilsho	1585	25	G	g	NN
cord-006229-7yoilsho	1585	26	protein	protein	NN
cord-006229-7yoilsho	1585	27	-	-	HYPH
cord-006229-7yoilsho	1585	28	coupled	couple	VBN
cord-006229-7yoilsho	1585	29	receptors	receptor	NNS
cord-006229-7yoilsho	1585	30	,	,	,
cord-006229-7yoilsho	1585	31	denoted	denote	VBN
cord-006229-7yoilsho	1585	32	S1P	s1p	NN
cord-006229-7yoilsho	1585	33	1	1	CD
cord-006229-7yoilsho	1585	34	-	-	SYM
cord-006229-7yoilsho	1585	35	5	5	CD
cord-006229-7yoilsho	1585	36	.	.	.
cord-006229-7yoilsho	1586	1	After	after	IN
cord-006229-7yoilsho	1586	2	activation	activation	NN
cord-006229-7yoilsho	1586	3	,	,	,
cord-006229-7yoilsho	1586	4	S1P	s1p	NN
cord-006229-7yoilsho	1586	5	receptors	receptor	NNS
cord-006229-7yoilsho	1586	6	regulate	regulate	VBP
cord-006229-7yoilsho	1586	7	important	important	JJ
cord-006229-7yoilsho	1586	8	processes	process	NNS
cord-006229-7yoilsho	1586	9	in	in	IN
cord-006229-7yoilsho	1586	10	the	the	DT
cord-006229-7yoilsho	1586	11	progression	progression	NN
cord-006229-7yoilsho	1586	12	of	of	IN
cord-006229-7yoilsho	1586	13	renal	renal	JJ
cord-006229-7yoilsho	1586	14	diseases	disease	NNS
cord-006229-7yoilsho	1586	15	,	,	,
cord-006229-7yoilsho	1586	16	such	such	JJ
cord-006229-7yoilsho	1586	17	as	as	IN
cord-006229-7yoilsho	1586	18	mesangial	mesangial	JJ
cord-006229-7yoilsho	1586	19	cell	cell	NN
cord-006229-7yoilsho	1586	20	migration	migration	NN
cord-006229-7yoilsho	1586	21	Methods	method	NNS
cord-006229-7yoilsho	1586	22	and	and	CC
cord-006229-7yoilsho	1586	23	Results	result	NNS
cord-006229-7yoilsho	1586	24	:	:	:
cord-006229-7yoilsho	1587	1	Here	here	RB
cord-006229-7yoilsho	1587	2	we	-PRON-	PRP
cord-006229-7yoilsho	1587	3	demonstrate	demonstrate	VBP
cord-006229-7yoilsho	1587	4	that	that	IN
cord-006229-7yoilsho	1587	5	dexamethasone	dexamethasone	NN
cord-006229-7yoilsho	1587	6	treatment	treatment	NN
cord-006229-7yoilsho	1587	7	lowered	lower	VBD
cord-006229-7yoilsho	1587	8	S1P	s1p	NN
cord-006229-7yoilsho	1587	9	1	1	CD
cord-006229-7yoilsho	1587	10	mRNA	mrna	NN
cord-006229-7yoilsho	1587	11	and	and	CC
cord-006229-7yoilsho	1587	12	protein	protein	NN
cord-006229-7yoilsho	1587	13	expression	expression	NN
cord-006229-7yoilsho	1587	14	levels	level	NNS
cord-006229-7yoilsho	1587	15	in	in	IN
cord-006229-7yoilsho	1587	16	rat	rat	NN
cord-006229-7yoilsho	1587	17	mesangial	mesangial	JJ
cord-006229-7yoilsho	1587	18	cells	cell	NNS
cord-006229-7yoilsho	1587	19	measured	measure	VBN
cord-006229-7yoilsho	1587	20	by	by	IN
cord-006229-7yoilsho	1587	21	TaqMan	TaqMan	NNP
cord-006229-7yoilsho	1587	22	®	®	NNPS
cord-006229-7yoilsho	1587	23	and	and	CC
cord-006229-7yoilsho	1587	24	Western	western	JJ
cord-006229-7yoilsho	1587	25	blot	blot	NN
cord-006229-7yoilsho	1587	26	analyses	analysis	NNS
cord-006229-7yoilsho	1587	27	.	.	.
cord-006229-7yoilsho	1588	1	This	this	DT
cord-006229-7yoilsho	1588	2	effect	effect	NN
cord-006229-7yoilsho	1588	3	was	be	VBD
cord-006229-7yoilsho	1588	4	abolished	abolish	VBN
cord-006229-7yoilsho	1588	5	in	in	IN
cord-006229-7yoilsho	1588	6	the	the	DT
cord-006229-7yoilsho	1588	7	presence	presence	NN
cord-006229-7yoilsho	1588	8	of	of	IN
cord-006229-7yoilsho	1588	9	the	the	DT
cord-006229-7yoilsho	1588	10	glucocorticoid	glucocorticoid	JJ
cord-006229-7yoilsho	1588	11	receptor	receptor	NN
cord-006229-7yoilsho	1588	12	antagonist	antagonist	NN
cord-006229-7yoilsho	1588	13	RU-486	ru-486	NN
cord-006229-7yoilsho	1588	14	.	.	.
cord-006229-7yoilsho	1589	1	In	in	IN
cord-006229-7yoilsho	1589	2	addition	addition	NN
cord-006229-7yoilsho	1589	3	,	,	,
cord-006229-7yoilsho	1589	4	in	in	IN
cord-006229-7yoilsho	1589	5	vivo	vivo	NNP
cord-006229-7yoilsho	1589	6	studies	study	NNS
cord-006229-7yoilsho	1589	7	showed	show	VBD
cord-006229-7yoilsho	1589	8	that	that	IN
cord-006229-7yoilsho	1589	9	dexamethasone	dexamethasone	NNP
cord-006229-7yoilsho	1589	10	downregulated	downregulate	VBD
cord-006229-7yoilsho	1589	11	S1P	s1p	NN
cord-006229-7yoilsho	1589	12	1	1	CD
cord-006229-7yoilsho	1589	13	expression	expression	NN
cord-006229-7yoilsho	1589	14	in	in	IN
cord-006229-7yoilsho	1589	15	glomeruli	glomerulus	NNS
cord-006229-7yoilsho	1589	16	isolated	isolate	VBN
cord-006229-7yoilsho	1589	17	from	from	IN
cord-006229-7yoilsho	1589	18	C57BL/6	C57BL/6	NNP
cord-006229-7yoilsho	1589	19	mice	mouse	NNS
cord-006229-7yoilsho	1589	20	treated	treat	VBN
cord-006229-7yoilsho	1589	21	with	with	IN
cord-006229-7yoilsho	1589	22	dexamethasone	dexamethasone	NN
cord-006229-7yoilsho	1589	23	(	(	-LRB-
cord-006229-7yoilsho	1589	24	10	10	CD
cord-006229-7yoilsho	1589	25	mg	mg	NNP
cord-006229-7yoilsho	1589	26	/	/	SYM
cord-006229-7yoilsho	1589	27	kg	kg	NN
cord-006229-7yoilsho	1589	28	body	body	NN
cord-006229-7yoilsho	1589	29	weight	weight	NN
cord-006229-7yoilsho	1589	30	)	)	-RRB-
cord-006229-7yoilsho	1589	31	.	.	.
cord-006229-7yoilsho	1590	1	Functionally	functionally	RB
cord-006229-7yoilsho	1590	2	,	,	,
cord-006229-7yoilsho	1590	3	we	-PRON-	PRP
cord-006229-7yoilsho	1590	4	identified	identify	VBD
cord-006229-7yoilsho	1590	5	S1P	s1p	NN
cord-006229-7yoilsho	1590	6	1	1	CD
cord-006229-7yoilsho	1590	7	as	as	IN
cord-006229-7yoilsho	1590	8	a	a	DT
cord-006229-7yoilsho	1590	9	key	key	JJ
cord-006229-7yoilsho	1590	10	player	player	NN
cord-006229-7yoilsho	1590	11	mediating	mediate	VBG
cord-006229-7yoilsho	1590	12	S1P	s1p	RB
cord-006229-7yoilsho	1590	13	-	-	HYPH
cord-006229-7yoilsho	1590	14	induced	induce	VBN
cord-006229-7yoilsho	1590	15	mesangial	mesangial	JJ
cord-006229-7yoilsho	1590	16	cell	cell	NN
cord-006229-7yoilsho	1590	17	migration	migration	NN
cord-006229-7yoilsho	1590	18	.	.	.
cord-006229-7yoilsho	1591	1	Using	use	VBG
cord-006229-7yoilsho	1591	2	Boyden	Boyden	NNP
cord-006229-7yoilsho	1591	3	Chamber	Chamber	NNP
cord-006229-7yoilsho	1591	4	assays	assay	NNS
cord-006229-7yoilsho	1591	5	,	,	,
cord-006229-7yoilsho	1591	6	we	-PRON-	PRP
cord-006229-7yoilsho	1591	7	could	could	MD
cord-006229-7yoilsho	1591	8	show	show	VB
cord-006229-7yoilsho	1591	9	that	that	IN
cord-006229-7yoilsho	1591	10	dexamethasone	dexamethasone	NN
cord-006229-7yoilsho	1591	11	treatment	treatment	NN
cord-006229-7yoilsho	1591	12	significantly	significantly	RB
cord-006229-7yoilsho	1591	13	lowered	lower	VBD
cord-006229-7yoilsho	1591	14	S1P	s1p	NN
cord-006229-7yoilsho	1591	15	-	-	HYPH
cord-006229-7yoilsho	1591	16	induced	induce	VBN
cord-006229-7yoilsho	1591	17	migration	migration	NN
cord-006229-7yoilsho	1591	18	of	of	IN
cord-006229-7yoilsho	1591	19	mesangial	mesangial	JJ
cord-006229-7yoilsho	1591	20	cells	cell	NNS
cord-006229-7yoilsho	1591	21	.	.	.
cord-006229-7yoilsho	1592	1	This	this	DT
cord-006229-7yoilsho	1592	2	effect	effect	NN
cord-006229-7yoilsho	1592	3	was	be	VBD
cord-006229-7yoilsho	1592	4	again	again	RB
cord-006229-7yoilsho	1592	5	reversed	reverse	VBN
cord-006229-7yoilsho	1592	6	in	in	IN
cord-006229-7yoilsho	1592	7	the	the	DT
cord-006229-7yoilsho	1592	8	presence	presence	NN
cord-006229-7yoilsho	1592	9	of	of	IN
cord-006229-7yoilsho	1592	10	RU-486	ru-486	NN
cord-006229-7yoilsho	1592	11	.	.	.
cord-006229-7yoilsho	1593	1	Conclusion	conclusion	NN
cord-006229-7yoilsho	1593	2	:	:	:
cord-006229-7yoilsho	1594	1	We	-PRON-	PRP
cord-006229-7yoilsho	1594	2	suggest	suggest	VBP
cord-006229-7yoilsho	1594	3	that	that	IN
cord-006229-7yoilsho	1594	4	dexamethasone	dexamethasone	NN
cord-006229-7yoilsho	1594	5	inhibits	inhibit	VBZ
cord-006229-7yoilsho	1594	6	S1P	s1p	CD
cord-006229-7yoilsho	1594	7	-	-	HYPH
cord-006229-7yoilsho	1594	8	induced	induce	VBN
cord-006229-7yoilsho	1594	9	mesangial	mesangial	JJ
cord-006229-7yoilsho	1594	10	cell	cell	NN
cord-006229-7yoilsho	1594	11	migration	migration	NN
cord-006229-7yoilsho	1594	12	via	via	IN
cord-006229-7yoilsho	1594	13	downregulation	downregulation	NN
cord-006229-7yoilsho	1594	14	of	of	IN
cord-006229-7yoilsho	1594	15	S1P	s1p	NN
cord-006229-7yoilsho	1594	16	1	1	CD
cord-006229-7yoilsho	1594	17	.	.	.
cord-006229-7yoilsho	1595	1	Overall	overall	RB
cord-006229-7yoilsho	1595	2	,	,	,
cord-006229-7yoilsho	1595	3	these	these	DT
cord-006229-7yoilsho	1595	4	results	result	NNS
cord-006229-7yoilsho	1595	5	demonstrate	demonstrate	VBP
cord-006229-7yoilsho	1595	6	that	that	IN
cord-006229-7yoilsho	1595	7	dexamethasone	dexamethasone	NN
cord-006229-7yoilsho	1595	8	has	have	VBZ
cord-006229-7yoilsho	1595	9	functional	functional	JJ
cord-006229-7yoilsho	1595	10	important	important	JJ
cord-006229-7yoilsho	1595	11	effects	effect	NNS
cord-006229-7yoilsho	1595	12	on	on	IN
cord-006229-7yoilsho	1595	13	sphingolipid	sphingolipid	NN
cord-006229-7yoilsho	1595	14	metabolism	metabolism	NN
cord-006229-7yoilsho	1595	15	and	and	CC
cord-006229-7yoilsho	1595	16	action	action	NN
cord-006229-7yoilsho	1595	17	in	in	IN
cord-006229-7yoilsho	1595	18	renal	renal	JJ
cord-006229-7yoilsho	1595	19	mesangial	mesangial	JJ
cord-006229-7yoilsho	1595	20	cells	cell	NNS
cord-006229-7yoilsho	1595	21	(	(	-LRB-
cord-006229-7yoilsho	1595	22	Koch	Koch	NNP
cord-006229-7yoilsho	1595	23	et	et	NNP
cord-006229-7yoilsho	1595	24	al	al	NNP
cord-006229-7yoilsho	1595	25	.	.	.
cord-006229-7yoilsho	1596	1	,	,	,
cord-006229-7yoilsho	1596	2	Biol	Biol	NNP
cord-006229-7yoilsho	1596	3	.	.	.
cord-006229-7yoilsho	1597	1	Chem	Chem	NNP
cord-006229-7yoilsho	1597	2	.	.	NNP
cord-006229-7yoilsho	1597	3	2015	2015	CD
cord-006229-7yoilsho	1597	4	;	;	:
cord-006229-7yoilsho	1597	5	396	396	CD
cord-006229-7yoilsho	1597	6	:	:	SYM
cord-006229-7yoilsho	1597	7	803	803	CD
cord-006229-7yoilsho	1597	8	-	-	SYM
cord-006229-7yoilsho	1597	9	12	12	CD
cord-006229-7yoilsho	1597	10	)	)	-RRB-
cord-006229-7yoilsho	1597	11	.	.	.
cord-006229-7yoilsho	1598	1	The	the	DT
cord-006229-7yoilsho	1598	2	G	G	NNP
cord-006229-7yoilsho	1598	3	protein	protein	NN
cord-006229-7yoilsho	1598	4	-	-	HYPH
cord-006229-7yoilsho	1598	5	coupled	couple	VBN
cord-006229-7yoilsho	1598	6	receptor	receptor	NN
cord-006229-7yoilsho	1598	7	MrgD	MrgD	NNP
cord-006229-7yoilsho	1598	8	is	be	VBZ
cord-006229-7yoilsho	1598	9	a	a	DT
cord-006229-7yoilsho	1598	10	receptor	receptor	NN
cord-006229-7yoilsho	1598	11	for	for	IN
cord-006229-7yoilsho	1598	12	angiotensin-(1	angiotensin-(1	CD
cord-006229-7yoilsho	1598	13	-	-	SYM
cord-006229-7yoilsho	1598	14	7	7	CD
cord-006229-7yoilsho	1598	15	)	)	-RRB-
cord-006229-7yoilsho	1598	16	involving	involve	VBG
cord-006229-7yoilsho	1598	17	G	G	NNP
cord-006229-7yoilsho	1598	18	alphaS	alphaS	NNP
cord-006229-7yoilsho	1598	19	,	,	,
cord-006229-7yoilsho	1598	20	cAMP	camp	NN
cord-006229-7yoilsho	1598	21	,	,	,
cord-006229-7yoilsho	1598	22	and	and	CC
cord-006229-7yoilsho	1598	23	phosphokinase	phosphokinase	VB
cord-006229-7yoilsho	1598	24	A	A	NNP
cord-006229-7yoilsho	1598	25	Rationale	rationale	NN
cord-006229-7yoilsho	1598	26	:	:	:
cord-006229-7yoilsho	1599	1	Angiotensin	angiotensin	NN
cord-006229-7yoilsho	1599	2	(	(	-LRB-
cord-006229-7yoilsho	1599	3	Ang)-(1	Ang)-(1	NNP
cord-006229-7yoilsho	1599	4	-	-	HYPH
cord-006229-7yoilsho	1599	5	7	7	NNP
cord-006229-7yoilsho	1599	6	)	)	-RRB-
cord-006229-7yoilsho	1599	7	has	have	VBZ
cord-006229-7yoilsho	1599	8	cardiovascular	cardiovascular	JJ
cord-006229-7yoilsho	1599	9	protective	protective	JJ
cord-006229-7yoilsho	1599	10	effects	effect	NNS
cord-006229-7yoilsho	1599	11	and	and	CC
cord-006229-7yoilsho	1599	12	is	be	VBZ
cord-006229-7yoilsho	1599	13	the	the	DT
cord-006229-7yoilsho	1599	14	opponent	opponent	NN
cord-006229-7yoilsho	1599	15	of	of	IN
cord-006229-7yoilsho	1599	16	the	the	DT
cord-006229-7yoilsho	1599	17	often	often	RB
cord-006229-7yoilsho	1599	18	detrimental	detrimental	JJ
cord-006229-7yoilsho	1599	19	Ang	Ang	NNP
cord-006229-7yoilsho	1599	20	II	II	NNP
cord-006229-7yoilsho	1599	21	within	within	IN
cord-006229-7yoilsho	1599	22	the	the	DT
cord-006229-7yoilsho	1599	23	renin	renin	NN
cord-006229-7yoilsho	1599	24	-	-	HYPH
cord-006229-7yoilsho	1599	25	angiotensin	angiotensin	NN
cord-006229-7yoilsho	1599	26	system	system	NN
cord-006229-7yoilsho	1599	27	.	.	.
cord-006229-7yoilsho	1600	1	Although	although	IN
cord-006229-7yoilsho	1600	2	it	-PRON-	PRP
cord-006229-7yoilsho	1600	3	is	be	VBZ
cord-006229-7yoilsho	1600	4	well	well	RB
cord-006229-7yoilsho	1600	5	-	-	HYPH
cord-006229-7yoilsho	1600	6	accepted	accept	VBN
cord-006229-7yoilsho	1600	7	that	that	IN
cord-006229-7yoilsho	1600	8	the	the	DT
cord-006229-7yoilsho	1600	9	G	g	NN
cord-006229-7yoilsho	1600	10	-	-	HYPH
cord-006229-7yoilsho	1600	11	protein	protein	NN
cord-006229-7yoilsho	1600	12	coupled	couple	VBN
cord-006229-7yoilsho	1600	13	receptor	receptor	NN
cord-006229-7yoilsho	1600	14	Mas	Mas	NNP
cord-006229-7yoilsho	1600	15	is	be	VBZ
cord-006229-7yoilsho	1600	16	a	a	DT
cord-006229-7yoilsho	1600	17	receptor	receptor	NN
cord-006229-7yoilsho	1600	18	for	for	IN
cord-006229-7yoilsho	1600	19	the	the	DT
cord-006229-7yoilsho	1600	20	heptapeptide	heptapeptide	NN
cord-006229-7yoilsho	1600	21	,	,	,
cord-006229-7yoilsho	1600	22	the	the	DT
cord-006229-7yoilsho	1600	23	lack	lack	NN
cord-006229-7yoilsho	1600	24	in	in	IN
cord-006229-7yoilsho	1600	25	knowing	know	VBG
cord-006229-7yoilsho	1600	26	initial	initial	JJ
cord-006229-7yoilsho	1600	27	signalling	signal	VBG
cord-006229-7yoilsho	1600	28	molecules	molecule	NNS
cord-006229-7yoilsho	1600	29	stimulated	stimulate	VBN
cord-006229-7yoilsho	1600	30	by	by	IN
cord-006229-7yoilsho	1600	31	Ang-(1	Ang-(1	NNP
cord-006229-7yoilsho	1600	32	-	-	HYPH
cord-006229-7yoilsho	1600	33	7	7	CD
cord-006229-7yoilsho	1600	34	)	)	-RRB-
cord-006229-7yoilsho	1600	35	prevented	prevent	VBD
cord-006229-7yoilsho	1600	36	final	final	JJ
cord-006229-7yoilsho	1600	37	verification	verification	NN
cord-006229-7yoilsho	1600	38	of	of	IN
cord-006229-7yoilsho	1600	39	ligand	ligand	NN
cord-006229-7yoilsho	1600	40	/	/	SYM
cord-006229-7yoilsho	1600	41	receptor	receptor	NN
cord-006229-7yoilsho	1600	42	interaction	interaction	NN
cord-006229-7yoilsho	1600	43	as	as	RB
cord-006229-7yoilsho	1600	44	well	well	RB
cord-006229-7yoilsho	1600	45	as	as	IN
cord-006229-7yoilsho	1600	46	the	the	DT
cord-006229-7yoilsho	1600	47	identification	identification	NN
cord-006229-7yoilsho	1600	48	of	of	IN
cord-006229-7yoilsho	1600	49	further	further	JJ
cord-006229-7yoilsho	1600	50	hypothesized	hypothesize	VBN
cord-006229-7yoilsho	1600	51	receptors	receptor	NNS
cord-006229-7yoilsho	1600	52	for	for	IN
cord-006229-7yoilsho	1600	53	the	the	DT
cord-006229-7yoilsho	1600	54	heptapeptide	heptapeptide	NN
cord-006229-7yoilsho	1600	55	.	.	.
cord-006229-7yoilsho	1601	1	Objective	objective	NN
cord-006229-7yoilsho	1601	2	:	:	:
cord-006229-7yoilsho	1602	1	The	the	DT
cord-006229-7yoilsho	1602	2	study	study	NN
cord-006229-7yoilsho	1602	3	aimed	aim	VBD
cord-006229-7yoilsho	1602	4	to	to	TO
cord-006229-7yoilsho	1602	5	identify	identify	VB
cord-006229-7yoilsho	1602	6	a	a	DT
cord-006229-7yoilsho	1602	7	second	second	JJ
cord-006229-7yoilsho	1602	8	messenger	messenger	NN
cord-006229-7yoilsho	1602	9	stimulated	stimulate	VBN
cord-006229-7yoilsho	1602	10	by	by	IN
cord-006229-7yoilsho	1602	11	Ang-(1	Ang-(1	NNP
cord-006229-7yoilsho	1602	12	-	-	HYPH
cord-006229-7yoilsho	1602	13	7	7	CD
cord-006229-7yoilsho	1602	14	)	)	-RRB-
cord-006229-7yoilsho	1602	15	allowing	allow	VBG
cord-006229-7yoilsho	1602	16	confirmation	confirmation	NN
cord-006229-7yoilsho	1602	17	as	as	RB
cord-006229-7yoilsho	1602	18	well	well	RB
cord-006229-7yoilsho	1602	19	as	as	IN
cord-006229-7yoilsho	1602	20	discovery	discovery	NN
cord-006229-7yoilsho	1602	21	of	of	IN
cord-006229-7yoilsho	1602	22	the	the	DT
cord-006229-7yoilsho	1602	23	heptapeptide	heptapeptide	NN
cord-006229-7yoilsho	1602	24	's	's	POS
cord-006229-7yoilsho	1602	25	receptors	receptor	NNS
cord-006229-7yoilsho	1602	26	.	.	.
cord-006229-7yoilsho	1603	1	We	-PRON-	PRP
cord-006229-7yoilsho	1603	2	identified	identify	VBD
cord-006229-7yoilsho	1603	3	cAMP	camp	NN
cord-006229-7yoilsho	1603	4	as	as	IN
cord-006229-7yoilsho	1603	5	the	the	DT
cord-006229-7yoilsho	1603	6	second	second	JJ
cord-006229-7yoilsho	1603	7	messenger	messenger	NN
cord-006229-7yoilsho	1603	8	for	for	IN
cord-006229-7yoilsho	1603	9	Ang-(1	Ang-(1	NNP
cord-006229-7yoilsho	1603	10	-	-	HYPH
cord-006229-7yoilsho	1603	11	7	7	CD
cord-006229-7yoilsho	1603	12	)	)	-RRB-
cord-006229-7yoilsho	1603	13	.	.	.
cord-006229-7yoilsho	1604	1	The	the	DT
cord-006229-7yoilsho	1604	2	heptapeptide	heptapeptide	NN
cord-006229-7yoilsho	1604	3	elevates	elevate	VBZ
cord-006229-7yoilsho	1604	4	cAMP	camp	NN
cord-006229-7yoilsho	1604	5	concentration	concentration	NN
cord-006229-7yoilsho	1604	6	in	in	IN
cord-006229-7yoilsho	1604	7	primary	primary	JJ
cord-006229-7yoilsho	1604	8	cells	cell	NNS
cord-006229-7yoilsho	1604	9	such	such	JJ
cord-006229-7yoilsho	1604	10	as	as	IN
cord-006229-7yoilsho	1604	11	endothelial	endothelial	JJ
cord-006229-7yoilsho	1604	12	or	or	CC
cord-006229-7yoilsho	1604	13	mesangial	mesangial	JJ
cord-006229-7yoilsho	1604	14	cells	cell	NNS
cord-006229-7yoilsho	1604	15	.	.	.
cord-006229-7yoilsho	1605	1	Using	use	VBG
cord-006229-7yoilsho	1605	2	cAMP	camp	NN
cord-006229-7yoilsho	1605	3	as	as	IN
cord-006229-7yoilsho	1605	4	readout	readout	NN
cord-006229-7yoilsho	1605	5	in	in	IN
cord-006229-7yoilsho	1605	6	receptor	receptor	NN
cord-006229-7yoilsho	1605	7	-	-	HYPH
cord-006229-7yoilsho	1605	8	transfected	transfecte	VBN
cord-006229-7yoilsho	1605	9	HEK293	HEK293	NNP
cord-006229-7yoilsho	1605	10	cells	cell	NNS
cord-006229-7yoilsho	1605	11	,	,	,
cord-006229-7yoilsho	1605	12	we	-PRON-	PRP
cord-006229-7yoilsho	1605	13	provided	provide	VBD
cord-006229-7yoilsho	1605	14	final	final	JJ
cord-006229-7yoilsho	1605	15	pharmacological	pharmacological	JJ
cord-006229-7yoilsho	1605	16	proof	proof	NN
cord-006229-7yoilsho	1605	17	for	for	IN
cord-006229-7yoilsho	1605	18	Mas	Mas	NNP
cord-006229-7yoilsho	1605	19	to	to	TO
cord-006229-7yoilsho	1605	20	be	be	VB
cord-006229-7yoilsho	1605	21	a	a	DT
cord-006229-7yoilsho	1605	22	receptor	receptor	NN
cord-006229-7yoilsho	1605	23	for	for	IN
cord-006229-7yoilsho	1605	24	Ang-(1	Ang-(1	NNP
cord-006229-7yoilsho	1605	25	-	-	HYPH
cord-006229-7yoilsho	1605	26	7	7	CD
cord-006229-7yoilsho	1605	27	)	)	-RRB-
cord-006229-7yoilsho	1605	28	.	.	.
cord-006229-7yoilsho	1606	1	More	more	RBR
cord-006229-7yoilsho	1606	2	important	important	JJ
cord-006229-7yoilsho	1606	3	,	,	,
cord-006229-7yoilsho	1606	4	we	-PRON-	PRP
cord-006229-7yoilsho	1606	5	identified	identify	VBD
cord-006229-7yoilsho	1606	6	the	the	DT
cord-006229-7yoilsho	1606	7	G	g	NN
cord-006229-7yoilsho	1606	8	-	-	HYPH
cord-006229-7yoilsho	1606	9	protein	protein	NN
cord-006229-7yoilsho	1606	10	coupled	couple	VBN
cord-006229-7yoilsho	1606	11	receptor	receptor	NN
cord-006229-7yoilsho	1606	12	MrgD	MrgD	NNP
cord-006229-7yoilsho	1606	13	as	as	IN
cord-006229-7yoilsho	1606	14	a	a	DT
cord-006229-7yoilsho	1606	15	second	second	JJ
cord-006229-7yoilsho	1606	16	receptor	receptor	NN
cord-006229-7yoilsho	1606	17	for	for	IN
cord-006229-7yoilsho	1606	18	Ang-(1	Ang-(1	NNP
cord-006229-7yoilsho	1606	19	-	-	HYPH
cord-006229-7yoilsho	1606	20	7	7	CD
cord-006229-7yoilsho	1606	21	)	)	-RRB-
cord-006229-7yoilsho	1606	22	.	.	.
cord-006229-7yoilsho	1607	1	Consequently	consequently	RB
cord-006229-7yoilsho	1607	2	,	,	,
cord-006229-7yoilsho	1607	3	the	the	DT
cord-006229-7yoilsho	1607	4	heptapeptide	heptapeptide	NN
cord-006229-7yoilsho	1607	5	failed	fail	VBD
cord-006229-7yoilsho	1607	6	to	to	TO
cord-006229-7yoilsho	1607	7	increase	increase	VB
cord-006229-7yoilsho	1607	8	cAMP	camp	NN
cord-006229-7yoilsho	1607	9	concentration	concentration	NN
cord-006229-7yoilsho	1607	10	in	in	IN
cord-006229-7yoilsho	1607	11	primary	primary	JJ
cord-006229-7yoilsho	1607	12	mesangial	mesangial	JJ
cord-006229-7yoilsho	1607	13	cells	cell	NNS
cord-006229-7yoilsho	1607	14	with	with	IN
cord-006229-7yoilsho	1607	15	genetic	genetic	JJ
cord-006229-7yoilsho	1607	16	deficiency	deficiency	NN
cord-006229-7yoilsho	1607	17	in	in	IN
cord-006229-7yoilsho	1607	18	both	both	CC
cord-006229-7yoilsho	1607	19	Mas	Mas	NNP
cord-006229-7yoilsho	1607	20	and	and	CC
cord-006229-7yoilsho	1607	21	MrgD.	MrgD.	NNP
cord-006229-7yoilsho	1608	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	1608	2	,	,	,
cord-006229-7yoilsho	1608	3	we	-PRON-	PRP
cord-006229-7yoilsho	1608	4	excluded	exclude	VBD
cord-006229-7yoilsho	1608	5	the	the	DT
cord-006229-7yoilsho	1608	6	Ang	Ang	NNP
cord-006229-7yoilsho	1608	7	II	II	NNP
cord-006229-7yoilsho	1608	8	type	type	NN
cord-006229-7yoilsho	1608	9	2	2	CD
cord-006229-7yoilsho	1608	10	receptor	receptor	NN
cord-006229-7yoilsho	1608	11	AT2	at2	NN
cord-006229-7yoilsho	1608	12	as	as	IN
cord-006229-7yoilsho	1608	13	a	a	DT
cord-006229-7yoilsho	1608	14	receptor	receptor	NN
cord-006229-7yoilsho	1608	15	for	for	IN
cord-006229-7yoilsho	1608	16	the	the	DT
cord-006229-7yoilsho	1608	17	heptapeptide	heptapeptide	NN
cord-006229-7yoilsho	1608	18	,	,	,
cord-006229-7yoilsho	1608	19	but	but	CC
cord-006229-7yoilsho	1608	20	discovered	discover	VBD
cord-006229-7yoilsho	1608	21	that	that	IN
cord-006229-7yoilsho	1608	22	the	the	DT
cord-006229-7yoilsho	1608	23	AT2	at2	NN
cord-006229-7yoilsho	1608	24	blocker	blocker	NN
cord-006229-7yoilsho	1608	25	PD123119	PD123119	NNP
cord-006229-7yoilsho	1608	26	can	can	MD
cord-006229-7yoilsho	1608	27	also	also	RB
cord-006229-7yoilsho	1608	28	block	block	VB
cord-006229-7yoilsho	1608	29	the	the	DT
cord-006229-7yoilsho	1608	30	Mas	Mas	NNP
cord-006229-7yoilsho	1608	31	and	and	CC
cord-006229-7yoilsho	1608	32	MrgD	MrgD	NNP
cord-006229-7yoilsho	1608	33	receptors	receptor	NNS
cord-006229-7yoilsho	1608	34	.	.	.
cord-006229-7yoilsho	1609	1	Conclusions	conclusion	NNS
cord-006229-7yoilsho	1609	2	:	:	:
cord-006229-7yoilsho	1610	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	1610	2	results	result	NNS
cord-006229-7yoilsho	1610	3	lead	lead	VBP
cord-006229-7yoilsho	1610	4	to	to	IN
cord-006229-7yoilsho	1610	5	an	an	DT
cord-006229-7yoilsho	1610	6	expansion	expansion	NN
cord-006229-7yoilsho	1610	7	and	and	CC
cord-006229-7yoilsho	1610	8	partial	partial	JJ
cord-006229-7yoilsho	1610	9	revision	revision	NN
cord-006229-7yoilsho	1610	10	of	of	IN
cord-006229-7yoilsho	1610	11	the	the	DT
cord-006229-7yoilsho	1610	12	reninangiotensin	reninangiotensin	NNP
cord-006229-7yoilsho	1610	13	system	system	NN
cord-006229-7yoilsho	1610	14	,	,	,
cord-006229-7yoilsho	1610	15	by	by	IN
cord-006229-7yoilsho	1610	16	identifying	identify	VBG
cord-006229-7yoilsho	1610	17	a	a	DT
cord-006229-7yoilsho	1610	18	second	second	JJ
cord-006229-7yoilsho	1610	19	receptor	receptor	NN
cord-006229-7yoilsho	1610	20	for	for	IN
cord-006229-7yoilsho	1610	21	the	the	DT
cord-006229-7yoilsho	1610	22	protective	protective	JJ
cord-006229-7yoilsho	1610	23	Ang-(1	Ang-(1	NNP
cord-006229-7yoilsho	1610	24	-	-	HYPH
cord-006229-7yoilsho	1610	25	7	7	CD
cord-006229-7yoilsho	1610	26	)	)	-RRB-
cord-006229-7yoilsho	1610	27	but	but	CC
cord-006229-7yoilsho	1610	28	excluding	exclude	VBG
cord-006229-7yoilsho	1610	29	the	the	DT
cord-006229-7yoilsho	1610	30	AT2	at2	NN
cord-006229-7yoilsho	1610	31	receptor	receptor	NN
cord-006229-7yoilsho	1610	32	,	,	,
cord-006229-7yoilsho	1610	33	and	and	CC
cord-006229-7yoilsho	1610	34	by	by	IN
cord-006229-7yoilsho	1610	35	enforcing	enforce	VBG
cord-006229-7yoilsho	1610	36	the	the	DT
cord-006229-7yoilsho	1610	37	revisit	revisit	NN
cord-006229-7yoilsho	1610	38	of	of	IN
cord-006229-7yoilsho	1610	39	such	such	JJ
cord-006229-7yoilsho	1610	40	publications	publication	NNS
cord-006229-7yoilsho	1610	41	which	which	WDT
cord-006229-7yoilsho	1610	42	concluded	conclude	VBD
cord-006229-7yoilsho	1610	43	AT2	at2	NN
cord-006229-7yoilsho	1610	44	function	function	NN
cord-006229-7yoilsho	1610	45	by	by	IN
cord-006229-7yoilsho	1610	46	using	use	VBG
cord-006229-7yoilsho	1610	47	PD123119	PD123119	NNP
cord-006229-7yoilsho	1610	48	as	as	IN
cord-006229-7yoilsho	1610	49	a	a	DT
cord-006229-7yoilsho	1610	50	specific	specific	JJ
cord-006229-7yoilsho	1610	51	AT2	at2	NN
cord-006229-7yoilsho	1610	52	blocker	blocker	NN
cord-006229-7yoilsho	1610	53	.	.	.
cord-006229-7yoilsho	1611	1	Members	member	NNS
cord-006229-7yoilsho	1611	2	of	of	IN
cord-006229-7yoilsho	1611	3	the	the	DT
cord-006229-7yoilsho	1611	4	G	g	NN
cord-006229-7yoilsho	1611	5	protein	protein	NN
cord-006229-7yoilsho	1611	6	-	-	HYPH
cord-006229-7yoilsho	1611	7	coupled	couple	VBN
cord-006229-7yoilsho	1611	8	receptor	receptor	NN
cord-006229-7yoilsho	1611	9	(	(	-LRB-
cord-006229-7yoilsho	1611	10	GPCR	GPCR	NNP
cord-006229-7yoilsho	1611	11	)	)	-RRB-
cord-006229-7yoilsho	1611	12	superfamily	superfamily	NN
cord-006229-7yoilsho	1611	13	are	be	VBP
cord-006229-7yoilsho	1611	14	integral	integral	JJ
cord-006229-7yoilsho	1611	15	membrane	membrane	NN
cord-006229-7yoilsho	1611	16	proteins	protein	NNS
cord-006229-7yoilsho	1611	17	that	that	WDT
cord-006229-7yoilsho	1611	18	are	be	VBP
cord-006229-7yoilsho	1611	19	activated	activate	VBN
cord-006229-7yoilsho	1611	20	by	by	IN
cord-006229-7yoilsho	1611	21	extracellular	extracellular	JJ
cord-006229-7yoilsho	1611	22	ligands	ligand	NNS
cord-006229-7yoilsho	1611	23	and	and	CC
cord-006229-7yoilsho	1611	24	induce	induce	VB
cord-006229-7yoilsho	1611	25	cell	cell	NN
cord-006229-7yoilsho	1611	26	signaling	signal	VBG
cord-006229-7yoilsho	1611	27	via	via	IN
cord-006229-7yoilsho	1611	28	G	g	NN
cord-006229-7yoilsho	1611	29	proteins	protein	NNS
cord-006229-7yoilsho	1611	30	and	and	CC
cord-006229-7yoilsho	1611	31	other	other	JJ
cord-006229-7yoilsho	1611	32	adaptor	adaptor	NN
cord-006229-7yoilsho	1611	33	proteins	protein	NNS
cord-006229-7yoilsho	1611	34	.	.	.
cord-006229-7yoilsho	1612	1	Rhodopsin	Rhodopsin	NNP
cord-006229-7yoilsho	1612	2	,	,	,
cord-006229-7yoilsho	1612	3	the	the	DT
cord-006229-7yoilsho	1612	4	prototypical	prototypical	JJ
cord-006229-7yoilsho	1612	5	GPCR	GPCR	NNP
cord-006229-7yoilsho	1612	6	that	that	WDT
cord-006229-7yoilsho	1612	7	mediates	mediate	VBZ
cord-006229-7yoilsho	1612	8	vision	vision	NN
cord-006229-7yoilsho	1612	9	,	,	,
cord-006229-7yoilsho	1612	10	is	be	VBZ
cord-006229-7yoilsho	1612	11	activated	activate	VBN
cord-006229-7yoilsho	1612	12	by	by	IN
cord-006229-7yoilsho	1612	13	photons	photon	NNS
cord-006229-7yoilsho	1612	14	that	that	WDT
cord-006229-7yoilsho	1612	15	isomerize	isomerize	VBP
cord-006229-7yoilsho	1612	16	its	-PRON-	PRP$
cord-006229-7yoilsho	1612	17	covalent	covalent	JJ
cord-006229-7yoilsho	1612	18	ligand	ligand	NN
cord-006229-7yoilsho	1612	19	.	.	.
cord-006229-7yoilsho	1613	1	Spectroscopic	spectroscopic	JJ
cord-006229-7yoilsho	1613	2	analyses	analysis	NNS
cord-006229-7yoilsho	1613	3	of	of	IN
cord-006229-7yoilsho	1613	4	the	the	DT
cord-006229-7yoilsho	1613	5	cognate	cognate	JJ
cord-006229-7yoilsho	1613	6	agonist	agonist	NN
cord-006229-7yoilsho	1613	7	retinal	retinal	JJ
cord-006229-7yoilsho	1613	8	allow	allow	VB
cord-006229-7yoilsho	1613	9	a	a	DT
cord-006229-7yoilsho	1613	10	detailed	detailed	JJ
cord-006229-7yoilsho	1613	11	description	description	NN
cord-006229-7yoilsho	1613	12	of	of	IN
cord-006229-7yoilsho	1613	13	rhodopsin	rhodopsin	NN
cord-006229-7yoilsho	1613	14	dynamics	dynamic	NNS
cord-006229-7yoilsho	1613	15	at	at	IN
cord-006229-7yoilsho	1613	16	submillisecond	submillisecond	NN
cord-006229-7yoilsho	1613	17	resolution	resolution	NN
cord-006229-7yoilsho	1613	18	.	.	.
cord-006229-7yoilsho	1614	1	Using	use	VBG
cord-006229-7yoilsho	1614	2	rhodopsin	rhodopsin	NN
cord-006229-7yoilsho	1614	3	as	as	IN
cord-006229-7yoilsho	1614	4	a	a	DT
cord-006229-7yoilsho	1614	5	model	model	NN
cord-006229-7yoilsho	1614	6	,	,	,
cord-006229-7yoilsho	1614	7	it	-PRON-	PRP
cord-006229-7yoilsho	1614	8	has	have	VBZ
cord-006229-7yoilsho	1614	9	been	be	VBN
cord-006229-7yoilsho	1614	10	demonstrated	demonstrate	VBN
cord-006229-7yoilsho	1614	11	that	that	IN
cord-006229-7yoilsho	1614	12	receptor	receptor	NN
cord-006229-7yoilsho	1614	13	activation	activation	NN
cord-006229-7yoilsho	1614	14	,	,	,
cord-006229-7yoilsho	1614	15	i.e.	i.e.	FW
cord-006229-7yoilsho	1614	16	a	a	DT
cord-006229-7yoilsho	1614	17	switch	switch	NN
cord-006229-7yoilsho	1614	18	from	from	IN
cord-006229-7yoilsho	1614	19	the	the	DT
cord-006229-7yoilsho	1614	20	fully	fully	RB
cord-006229-7yoilsho	1614	21	inactive	inactive	JJ
cord-006229-7yoilsho	1614	22	to	to	IN
cord-006229-7yoilsho	1614	23	the	the	DT
cord-006229-7yoilsho	1614	24	fully	fully	RB
cord-006229-7yoilsho	1614	25	active	active	JJ
cord-006229-7yoilsho	1614	26	state	state	NN
cord-006229-7yoilsho	1614	27	,	,	,
cord-006229-7yoilsho	1614	28	occurs	occur	VBZ
cord-006229-7yoilsho	1614	29	within	within	IN
cord-006229-7yoilsho	1614	30	1	1	CD
cord-006229-7yoilsho	1614	31	ms	ms	NNP
cord-006229-7yoilsho	1614	32	1	1	CD
cord-006229-7yoilsho	1614	33	.	.	.
cord-006229-7yoilsho	1615	1	Activation	activation	NN
cord-006229-7yoilsho	1615	2	kinetics	kinetic	NNS
cord-006229-7yoilsho	1615	3	of	of	IN
cord-006229-7yoilsho	1615	4	other	other	JJ
cord-006229-7yoilsho	1615	5	receptors	receptor	NNS
cord-006229-7yoilsho	1615	6	have	have	VBP
cord-006229-7yoilsho	1615	7	been	be	VBN
cord-006229-7yoilsho	1615	8	studied	study	VBN
cord-006229-7yoilsho	1615	9	mainly	mainly	RB
cord-006229-7yoilsho	1615	10	using	use	VBG
cord-006229-7yoilsho	1615	11	fluorescence	fluorescence	NN
cord-006229-7yoilsho	1615	12	resonance	resonance	NN
cord-006229-7yoilsho	1615	13	energy	energy	NN
cord-006229-7yoilsho	1615	14	transfer	transfer	NN
cord-006229-7yoilsho	1615	15	(	(	-LRB-
cord-006229-7yoilsho	1615	16	FRET	fret	NN
cord-006229-7yoilsho	1615	17	)	)	-RRB-
cord-006229-7yoilsho	1615	18	which	which	WDT
cord-006229-7yoilsho	1615	19	allows	allow	VBZ
cord-006229-7yoilsho	1615	20	kinetic	kinetic	JJ
cord-006229-7yoilsho	1615	21	studies	study	NNS
cord-006229-7yoilsho	1615	22	with	with	IN
cord-006229-7yoilsho	1615	23	high	high	JJ
cord-006229-7yoilsho	1615	24	resolution	resolution	NN
cord-006229-7yoilsho	1615	25	in	in	IN
cord-006229-7yoilsho	1615	26	living	living	NN
cord-006229-7yoilsho	1615	27	cells	cell	NNS
cord-006229-7yoilsho	1615	28	2	2	CD
cord-006229-7yoilsho	1615	29	.	.	.
cord-006229-7yoilsho	1616	1	In	in	IN
cord-006229-7yoilsho	1616	2	contrast	contrast	NN
cord-006229-7yoilsho	1616	3	to	to	IN
cord-006229-7yoilsho	1616	4	rhodopsin	rhodopsin	NN
cord-006229-7yoilsho	1616	5	,	,	,
cord-006229-7yoilsho	1616	6	activation	activation	NN
cord-006229-7yoilsho	1616	7	constants	constant	NNS
cord-006229-7yoilsho	1616	8	of	of	IN
cord-006229-7yoilsho	1616	9	several	several	JJ
cord-006229-7yoilsho	1616	10	GPCRs	gpcr	NNS
cord-006229-7yoilsho	1616	11	using	use	VBG
cord-006229-7yoilsho	1616	12	agonist	agonist	NN
cord-006229-7yoilsho	1616	13	superfusion	superfusion	NN
cord-006229-7yoilsho	1616	14	have	have	VBP
cord-006229-7yoilsho	1616	15	been	be	VBN
cord-006229-7yoilsho	1616	16	determined	determine	VBN
cord-006229-7yoilsho	1616	17	to	to	TO
cord-006229-7yoilsho	1616	18	range	range	VB
cord-006229-7yoilsho	1616	19	between	between	IN
cord-006229-7yoilsho	1616	20	30	30	CD
cord-006229-7yoilsho	1616	21	-	-	SYM
cord-006229-7yoilsho	1616	22	80	80	CD
cord-006229-7yoilsho	1616	23	ms	ms	NNP
cord-006229-7yoilsho	1616	24	3	3	CD
cord-006229-7yoilsho	1616	25	.	.	.
cord-006229-7yoilsho	1617	1	However	however	RB
cord-006229-7yoilsho	1617	2	,	,	,
cord-006229-7yoilsho	1617	3	it	-PRON-	PRP
cord-006229-7yoilsho	1617	4	is	be	VBZ
cord-006229-7yoilsho	1617	5	unknown	unknown	JJ
cord-006229-7yoilsho	1617	6	if	if	IN
cord-006229-7yoilsho	1617	7	all	all	DT
cord-006229-7yoilsho	1617	8	GPCRs	gpcr	NNS
cord-006229-7yoilsho	1617	9	with	with	IN
cord-006229-7yoilsho	1617	10	diffusible	diffusible	JJ
cord-006229-7yoilsho	1617	11	ligands	ligand	NNS
cord-006229-7yoilsho	1617	12	are	be	VBP
cord-006229-7yoilsho	1617	13	really	really	RB
cord-006229-7yoilsho	1617	14	activated	activate	VBN
cord-006229-7yoilsho	1617	15	on	on	IN
cord-006229-7yoilsho	1617	16	a	a	DT
cord-006229-7yoilsho	1617	17	longer	long	JJR
cord-006229-7yoilsho	1617	18	timescale	timescale	NN
cord-006229-7yoilsho	1617	19	or	or	CC
cord-006229-7yoilsho	1617	20	if	if	IN
cord-006229-7yoilsho	1617	21	ligand	ligand	NN
cord-006229-7yoilsho	1617	22	diffusion	diffusion	NN
cord-006229-7yoilsho	1617	23	to	to	IN
cord-006229-7yoilsho	1617	24	the	the	DT
cord-006229-7yoilsho	1617	25	binding	binding	NN
cord-006229-7yoilsho	1617	26	site	site	NN
cord-006229-7yoilsho	1617	27	is	be	VBZ
cord-006229-7yoilsho	1617	28	rate	rate	NN
cord-006229-7yoilsho	1617	29	limiting	limit	VBG
cord-006229-7yoilsho	1617	30	.	.	.
cord-006229-7yoilsho	1618	1	In	in	IN
cord-006229-7yoilsho	1618	2	this	this	DT
cord-006229-7yoilsho	1618	3	study	study	NN
cord-006229-7yoilsho	1618	4	,	,	,
cord-006229-7yoilsho	1618	5	we	-PRON-	PRP
cord-006229-7yoilsho	1618	6	intend	intend	VBP
cord-006229-7yoilsho	1618	7	to	to	TO
cord-006229-7yoilsho	1618	8	overcome	overcome	VB
cord-006229-7yoilsho	1618	9	ligand	ligand	NN
cord-006229-7yoilsho	1618	10	diffusion	diffusion	NN
cord-006229-7yoilsho	1618	11	by	by	IN
cord-006229-7yoilsho	1618	12	using	use	VBG
cord-006229-7yoilsho	1618	13	photodestruction	photodestruction	NN
cord-006229-7yoilsho	1618	14	of	of	IN
cord-006229-7yoilsho	1618	15	caged	cage	VBN
cord-006229-7yoilsho	1618	16	ligands	ligand	NNS
cord-006229-7yoilsho	1618	17	.	.	.
cord-006229-7yoilsho	1619	1	We	-PRON-	PRP
cord-006229-7yoilsho	1619	2	monitor	monitor	VBP
cord-006229-7yoilsho	1619	3	activation	activation	NN
cord-006229-7yoilsho	1619	4	-	-	HYPH
cord-006229-7yoilsho	1619	5	related	relate	VBN
cord-006229-7yoilsho	1619	6	conformational	conformational	JJ
cord-006229-7yoilsho	1619	7	changes	change	NNS
cord-006229-7yoilsho	1619	8	of	of	IN
cord-006229-7yoilsho	1619	9	homodimeric	homodimeric	NNP
cord-006229-7yoilsho	1619	10	metabotropic	metabotropic	NNP
cord-006229-7yoilsho	1619	11	glutamate	glutamate	NN
cord-006229-7yoilsho	1619	12	receptor	receptor	NN
cord-006229-7yoilsho	1619	13	1	1	CD
cord-006229-7yoilsho	1619	14	(	(	-LRB-
cord-006229-7yoilsho	1619	15	mGluR1	mGluR1	NNP
cord-006229-7yoilsho	1619	16	)	)	-RRB-
cord-006229-7yoilsho	1619	17	sensors	sensor	NNS
cord-006229-7yoilsho	1619	18	by	by	IN
cord-006229-7yoilsho	1619	19	FRET	fret	NN
cord-006229-7yoilsho	1619	20	after	after	IN
cord-006229-7yoilsho	1619	21	uncaging	uncage	VBG
cord-006229-7yoilsho	1619	22	of	of	IN
cord-006229-7yoilsho	1619	23	an	an	DT
cord-006229-7yoilsho	1619	24	inert	inert	JJ
cord-006229-7yoilsho	1619	25	glutamate	glutamate	NN
cord-006229-7yoilsho	1619	26	derivative	derivative	JJ
cord-006229-7yoilsho	1619	27	.	.	.
cord-006229-7yoilsho	1620	1	4-Methoxy-7-nitroindolinyl	4-methoxy-7-nitroindolinyl	CD
cord-006229-7yoilsho	1621	1	-L	-L	:
cord-006229-7yoilsho	1621	2	-	-	HYPH
cord-006229-7yoilsho	1621	3	glutamate	glutamate	NN
cord-006229-7yoilsho	1621	4	(	(	-LRB-
cord-006229-7yoilsho	1621	5	MNI	MNI	NNP
cord-006229-7yoilsho	1621	6	-	-	HYPH
cord-006229-7yoilsho	1621	7	glutamate	glutamate	NN
cord-006229-7yoilsho	1621	8	)	)	-RRB-
cord-006229-7yoilsho	1621	9	is	be	VBZ
cord-006229-7yoilsho	1621	10	a	a	DT
cord-006229-7yoilsho	1621	11	caged	cage	VBN
cord-006229-7yoilsho	1621	12	derivative	derivative	NN
cord-006229-7yoilsho	1621	13	of	of	IN
cord-006229-7yoilsho	1621	14	glutamate	glutamate	NN
cord-006229-7yoilsho	1621	15	that	that	WDT
cord-006229-7yoilsho	1621	16	does	do	VBZ
cord-006229-7yoilsho	1621	17	not	not	RB
cord-006229-7yoilsho	1621	18	activate	activate	VB
cord-006229-7yoilsho	1621	19	mGluR1s	mglur1s	CD
cord-006229-7yoilsho	1621	20	.	.	.
cord-006229-7yoilsho	1622	1	Upon	upon	IN
cord-006229-7yoilsho	1622	2	pre	pre	JJ
cord-006229-7yoilsho	1622	3	-	-	NN
cord-006229-7yoilsho	1622	4	incubation	incubation	NN
cord-006229-7yoilsho	1622	5	of	of	IN
cord-006229-7yoilsho	1622	6	HEK	HEK	NNP
cord-006229-7yoilsho	1622	7	-	-	HYPH
cord-006229-7yoilsho	1622	8	TsA	TsA	VBN
cord-006229-7yoilsho	1622	9	cells	cell	NNS
cord-006229-7yoilsho	1622	10	expressing	express	VBG
cord-006229-7yoilsho	1622	11	both	both	DT
cord-006229-7yoilsho	1622	12	CFP	CFP	NNP
cord-006229-7yoilsho	1622	13	-	-	,
cord-006229-7yoilsho	1622	14	and	and	CC
cord-006229-7yoilsho	1622	15	YFP	YFP	NNP
cord-006229-7yoilsho	1622	16	-	-	HYPH
cord-006229-7yoilsho	1622	17	tagged	tag	VBN
cord-006229-7yoilsho	1622	18	mGluR1	mGluR1	NNP
cord-006229-7yoilsho	1622	19	protomers	protomer	NNS
cord-006229-7yoilsho	1622	20	with	with	IN
cord-006229-7yoilsho	1622	21	MNIglutamate	MNIglutamate	NNP
cord-006229-7yoilsho	1622	22	,	,	,
cord-006229-7yoilsho	1622	23	a	a	DT
cord-006229-7yoilsho	1622	24	short	short	JJ
cord-006229-7yoilsho	1622	25	UV	uv	NN
cord-006229-7yoilsho	1622	26	laser	laser	NN
cord-006229-7yoilsho	1622	27	pulse	pulse	NN
cord-006229-7yoilsho	1622	28	releases	release	VBZ
cord-006229-7yoilsho	1622	29	active	active	JJ
cord-006229-7yoilsho	1622	30	L	l	NN
cord-006229-7yoilsho	1622	31	-	-	HYPH
cord-006229-7yoilsho	1622	32	glutamate	glutamate	NN
cord-006229-7yoilsho	1622	33	close	close	RB
cord-006229-7yoilsho	1622	34	to	to	IN
cord-006229-7yoilsho	1622	35	the	the	DT
cord-006229-7yoilsho	1622	36	receptor	receptor	NN
cord-006229-7yoilsho	1622	37	binding	bind	VBG
cord-006229-7yoilsho	1622	38	site	site	NN
cord-006229-7yoilsho	1622	39	.	.	.
cord-006229-7yoilsho	1623	1	We	-PRON-	PRP
cord-006229-7yoilsho	1623	2	demonstrate	demonstrate	VBP
cord-006229-7yoilsho	1623	3	very	very	RB
cord-006229-7yoilsho	1623	4	rapid	rapid	JJ
cord-006229-7yoilsho	1623	5	mGluR1	mGluR1	NNP
cord-006229-7yoilsho	1623	6	activation	activation	NN
cord-006229-7yoilsho	1623	7	kinetics	kinetic	NNS
cord-006229-7yoilsho	1623	8	and	and	CC
cord-006229-7yoilsho	1623	9	this	this	DT
cord-006229-7yoilsho	1623	10	allows	allow	VBZ
cord-006229-7yoilsho	1623	11	us	-PRON-	PRP
cord-006229-7yoilsho	1623	12	to	to	TO
cord-006229-7yoilsho	1623	13	study	study	VB
cord-006229-7yoilsho	1623	14	the	the	DT
cord-006229-7yoilsho	1623	15	process	process	NN
cord-006229-7yoilsho	1623	16	of	of	IN
cord-006229-7yoilsho	1623	17	signal	signal	JJ
cord-006229-7yoilsho	1623	18	transduction	transduction	NN
cord-006229-7yoilsho	1623	19	of	of	IN
cord-006229-7yoilsho	1623	20	this	this	DT
cord-006229-7yoilsho	1623	21	homodimeric	homodimeric	JJ
cord-006229-7yoilsho	1623	22	GPCRs	gpcr	NNS
cord-006229-7yoilsho	1623	23	Opioids	opioid	NNS
cord-006229-7yoilsho	1623	24	are	be	VBP
cord-006229-7yoilsho	1623	25	still	still	RB
cord-006229-7yoilsho	1623	26	the	the	DT
cord-006229-7yoilsho	1623	27	mainstay	mainstay	NN
cord-006229-7yoilsho	1623	28	of	of	IN
cord-006229-7yoilsho	1623	29	modern	modern	JJ
cord-006229-7yoilsho	1623	30	pain	pain	NN
cord-006229-7yoilsho	1623	31	treatment	treatment	NN
cord-006229-7yoilsho	1623	32	.	.	.
cord-006229-7yoilsho	1624	1	Most	Most	JJS
cord-006229-7yoilsho	1624	2	of	of	IN
cord-006229-7yoilsho	1624	3	the	the	DT
cord-006229-7yoilsho	1624	4	clinically	clinically	RB
cord-006229-7yoilsho	1624	5	established	establish	VBN
cord-006229-7yoilsho	1624	6	substances	substance	NNS
cord-006229-7yoilsho	1624	7	primarily	primarily	RB
cord-006229-7yoilsho	1624	8	exert	exert	VBP
cord-006229-7yoilsho	1624	9	their	-PRON-	PRP$
cord-006229-7yoilsho	1624	10	effects	effect	NNS
cord-006229-7yoilsho	1624	11	via	via	IN
cord-006229-7yoilsho	1624	12	the	the	DT
cord-006229-7yoilsho	1624	13	µ-opioid	µ-opioid	NN
cord-006229-7yoilsho	1624	14	receptor	receptor	NN
cord-006229-7yoilsho	1624	15	(	(	-LRB-
cord-006229-7yoilsho	1624	16	MOR	MOR	NNP
cord-006229-7yoilsho	1624	17	)	)	-RRB-
cord-006229-7yoilsho	1624	18	.	.	.
cord-006229-7yoilsho	1625	1	However	however	RB
cord-006229-7yoilsho	1625	2	,	,	,
cord-006229-7yoilsho	1625	3	many	many	JJ
cord-006229-7yoilsho	1625	4	side	side	NN
cord-006229-7yoilsho	1625	5	effects	effect	NNS
cord-006229-7yoilsho	1625	6	such	such	JJ
cord-006229-7yoilsho	1625	7	as	as	IN
cord-006229-7yoilsho	1625	8	tolerance	tolerance	NN
cord-006229-7yoilsho	1625	9	,	,	,
cord-006229-7yoilsho	1625	10	constipation	constipation	NN
cord-006229-7yoilsho	1625	11	and	and	CC
cord-006229-7yoilsho	1625	12	respiratory	respiratory	JJ
cord-006229-7yoilsho	1625	13	depression	depression	NN
cord-006229-7yoilsho	1625	14	limit	limit	VBP
cord-006229-7yoilsho	1625	15	their	-PRON-	PRP$
cord-006229-7yoilsho	1625	16	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	1625	17	use	use	NN
cord-006229-7yoilsho	1625	18	.	.	.
cord-006229-7yoilsho	1626	1	The	the	DT
cord-006229-7yoilsho	1626	2	efficacy	efficacy	NN
cord-006229-7yoilsho	1626	3	of	of	IN
cord-006229-7yoilsho	1626	4	MOR	MOR	NNP
cord-006229-7yoilsho	1626	5	agonists	agonist	NNS
cord-006229-7yoilsho	1626	6	in	in	IN
cord-006229-7yoilsho	1626	7	the	the	DT
cord-006229-7yoilsho	1626	8	treatment	treatment	NN
cord-006229-7yoilsho	1626	9	of	of	IN
cord-006229-7yoilsho	1626	10	chronic	chronic	JJ
cord-006229-7yoilsho	1626	11	pain	pain	NN
cord-006229-7yoilsho	1626	12	is	be	VBZ
cord-006229-7yoilsho	1626	13	unsatisfactory	unsatisfactory	JJ
cord-006229-7yoilsho	1626	14	.	.	.
cord-006229-7yoilsho	1627	1	In	in	IN
cord-006229-7yoilsho	1627	2	general	general	JJ
cord-006229-7yoilsho	1627	3	analgesic	analgesic	JJ
cord-006229-7yoilsho	1627	4	effects	effect	NNS
cord-006229-7yoilsho	1627	5	can	can	MD
cord-006229-7yoilsho	1627	6	be	be	VB
cord-006229-7yoilsho	1627	7	mediated	mediate	VBN
cord-006229-7yoilsho	1627	8	by	by	IN
cord-006229-7yoilsho	1627	9	all	all	DT
cord-006229-7yoilsho	1627	10	four	four	CD
cord-006229-7yoilsho	1627	11	members	member	NNS
cord-006229-7yoilsho	1627	12	of	of	IN
cord-006229-7yoilsho	1627	13	the	the	DT
cord-006229-7yoilsho	1627	14	opioid	opioid	JJ
cord-006229-7yoilsho	1627	15	receptor	receptor	NN
cord-006229-7yoilsho	1627	16	family	family	NN
cord-006229-7yoilsho	1627	17	.	.	.
cord-006229-7yoilsho	1628	1	The	the	DT
cord-006229-7yoilsho	1628	2	nociception	nociception	NN
cord-006229-7yoilsho	1628	3	receptor	receptor	NN
cord-006229-7yoilsho	1628	4	(	(	-LRB-
cord-006229-7yoilsho	1628	5	NOP	NOP	NNP
cord-006229-7yoilsho	1628	6	)	)	-RRB-
cord-006229-7yoilsho	1628	7	is	be	VBZ
cord-006229-7yoilsho	1628	8	the	the	DT
cord-006229-7yoilsho	1628	9	latest	late	JJS
cord-006229-7yoilsho	1628	10	member	member	NN
cord-006229-7yoilsho	1628	11	of	of	IN
cord-006229-7yoilsho	1628	12	the	the	DT
cord-006229-7yoilsho	1628	13	opioid	opioid	JJ
cord-006229-7yoilsho	1628	14	receptor	receptor	NN
cord-006229-7yoilsho	1628	15	family	family	NN
cord-006229-7yoilsho	1628	16	.	.	.
cord-006229-7yoilsho	1629	1	There	there	EX
cord-006229-7yoilsho	1629	2	is	be	VBZ
cord-006229-7yoilsho	1629	3	a	a	DT
cord-006229-7yoilsho	1629	4	rapidly	rapidly	RB
cord-006229-7yoilsho	1629	5	growing	grow	VBG
cord-006229-7yoilsho	1629	6	interest	interest	NN
cord-006229-7yoilsho	1629	7	for	for	IN
cord-006229-7yoilsho	1629	8	the	the	DT
cord-006229-7yoilsho	1629	9	development	development	NN
cord-006229-7yoilsho	1629	10	of	of	IN
cord-006229-7yoilsho	1629	11	novel	novel	NN
cord-006229-7yoilsho	1629	12	NOP	nop	NN
cord-006229-7yoilsho	1629	13	and	and	CC
cord-006229-7yoilsho	1629	14	combined	combine	VBN
cord-006229-7yoilsho	1629	15	MOR	MOR	NNP
cord-006229-7yoilsho	1629	16	/	/	SYM
cord-006229-7yoilsho	1629	17	NOP	NOP	NNP
cord-006229-7yoilsho	1629	18	agonists	agonist	NNS
cord-006229-7yoilsho	1629	19	.	.	.
cord-006229-7yoilsho	1630	1	The	the	DT
cord-006229-7yoilsho	1630	2	aim	aim	NN
cord-006229-7yoilsho	1630	3	of	of	IN
cord-006229-7yoilsho	1630	4	this	this	DT
cord-006229-7yoilsho	1630	5	developement	developement	NN
cord-006229-7yoilsho	1630	6	is	be	VBZ
cord-006229-7yoilsho	1630	7	novel	novel	JJ
cord-006229-7yoilsho	1630	8	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	1630	9	agents	agent	NNS
cord-006229-7yoilsho	1630	10	with	with	IN
cord-006229-7yoilsho	1630	11	improved	improved	JJ
cord-006229-7yoilsho	1630	12	analgesic	analgesic	JJ
cord-006229-7yoilsho	1630	13	characteristics	characteristic	NNS
cord-006229-7yoilsho	1630	14	and	and	CC
cord-006229-7yoilsho	1630	15	less	less	JJR
cord-006229-7yoilsho	1630	16	classical	classical	JJ
cord-006229-7yoilsho	1630	17	MOR	MOR	NNP
cord-006229-7yoilsho	1630	18	-	-	HYPH
cord-006229-7yoilsho	1630	19	mediated	mediate	VBN
cord-006229-7yoilsho	1630	20	side	side	NN
cord-006229-7yoilsho	1630	21	effects	effect	NNS
cord-006229-7yoilsho	1630	22	.	.	.
cord-006229-7yoilsho	1631	1	Here	here	RB
cord-006229-7yoilsho	1631	2	we	-PRON-	PRP
cord-006229-7yoilsho	1631	3	used	use	VBD
cord-006229-7yoilsho	1631	4	Buprenorphine	Buprenorphine	NNP
cord-006229-7yoilsho	1631	5	as	as	IN
cord-006229-7yoilsho	1631	6	a	a	DT
cord-006229-7yoilsho	1631	7	clinically	clinically	RB
cord-006229-7yoilsho	1631	8	established	establish	VBN
cord-006229-7yoilsho	1631	9	opioid	opioid	NN
cord-006229-7yoilsho	1631	10	which	which	WDT
cord-006229-7yoilsho	1631	11	exerts	exert	VBZ
cord-006229-7yoilsho	1631	12	its	-PRON-	PRP$
cord-006229-7yoilsho	1631	13	effect	effect	NN
cord-006229-7yoilsho	1631	14	on	on	IN
cord-006229-7yoilsho	1631	15	multiple	multiple	JJ
cord-006229-7yoilsho	1631	16	opioid	opioid	JJ
cord-006229-7yoilsho	1631	17	receptor	receptor	NN
cord-006229-7yoilsho	1631	18	subtypes	subtype	NNS
cord-006229-7yoilsho	1631	19	.	.	.
cord-006229-7yoilsho	1632	1	Recently	recently	RB
cord-006229-7yoilsho	1632	2	,	,	,
cord-006229-7yoilsho	1632	3	Nalfurafine	Nalfurafine	NNP
cord-006229-7yoilsho	1632	4	,	,	,
cord-006229-7yoilsho	1632	5	a	a	DT
cord-006229-7yoilsho	1632	6	potent	potent	JJ
cord-006229-7yoilsho	1632	7	kappa	kappa	NN
cord-006229-7yoilsho	1632	8	-	-	HYPH
cord-006229-7yoilsho	1632	9	opioid	opioid	NN
cord-006229-7yoilsho	1632	10	receptor	receptor	NN
cord-006229-7yoilsho	1632	11	(	(	-LRB-
cord-006229-7yoilsho	1632	12	KOR	KOR	NNP
cord-006229-7yoilsho	1632	13	)	)	-RRB-
cord-006229-7yoilsho	1632	14	agonist	agonist	NN
cord-006229-7yoilsho	1632	15	was	be	VBD
cord-006229-7yoilsho	1632	16	granted	grant	VBN
cord-006229-7yoilsho	1632	17	by	by	IN
cord-006229-7yoilsho	1632	18	Japanese	japanese	JJ
cord-006229-7yoilsho	1632	19	authorities	authority	NNS
cord-006229-7yoilsho	1632	20	for	for	IN
cord-006229-7yoilsho	1632	21	the	the	DT
cord-006229-7yoilsho	1632	22	treatment	treatment	NN
cord-006229-7yoilsho	1632	23	of	of	IN
cord-006229-7yoilsho	1632	24	uremic	uremic	JJ
cord-006229-7yoilsho	1632	25	pruritus	pruritus	NN
cord-006229-7yoilsho	1632	26	.	.	.
cord-006229-7yoilsho	1633	1	Even	even	RB
cord-006229-7yoilsho	1633	2	though	though	IN
cord-006229-7yoilsho	1633	3	KOR	KOR	NNP
cord-006229-7yoilsho	1633	4	agonists	agonist	NNS
cord-006229-7yoilsho	1633	5	are	be	VBP
cord-006229-7yoilsho	1633	6	known	know	VBN
cord-006229-7yoilsho	1633	7	to	to	TO
cord-006229-7yoilsho	1633	8	mediate	mediate	VB
cord-006229-7yoilsho	1633	9	dysphoria	dysphoria	NN
cord-006229-7yoilsho	1633	10	and	and	CC
cord-006229-7yoilsho	1633	11	hallucinations	hallucination	NNS
cord-006229-7yoilsho	1633	12	this	this	DT
cord-006229-7yoilsho	1633	13	has	have	VBZ
cord-006229-7yoilsho	1633	14	not	not	RB
cord-006229-7yoilsho	1633	15	been	be	VBN
cord-006229-7yoilsho	1633	16	reported	report	VBN
cord-006229-7yoilsho	1633	17	for	for	IN
cord-006229-7yoilsho	1633	18	Nalfurafine	Nalfurafine	NNP
cord-006229-7yoilsho	1633	19	.	.	.
cord-006229-7yoilsho	1634	1	Rudolf	Rudolf	NNP
cord-006229-7yoilsho	1634	2	-	-	HYPH
cord-006229-7yoilsho	1634	3	Virchow	Virchow	NNP
cord-006229-7yoilsho	1634	4	-	-	HYPH
cord-006229-7yoilsho	1634	5	Zentrum	Zentrum	NNP
cord-006229-7yoilsho	1634	6	für	für	NNP
cord-006229-7yoilsho	1635	1	Experimentelle	Experimentelle	NNP
cord-006229-7yoilsho	1635	2	Biomedizin	Biomedizin	NNP
cord-006229-7yoilsho	1635	3	,	,	,
cord-006229-7yoilsho	1635	4	Würzburg	Würzburg	NNP
cord-006229-7yoilsho	1635	5	,	,	,
cord-006229-7yoilsho	1635	6	Germany	Germany	NNP
cord-006229-7yoilsho	1635	7	G	G	NNP
cord-006229-7yoilsho	1635	8	protein	protein	NN
cord-006229-7yoilsho	1635	9	-	-	HYPH
cord-006229-7yoilsho	1635	10	coupled	couple	VBN
cord-006229-7yoilsho	1635	11	receptors	receptor	NNS
cord-006229-7yoilsho	1635	12	(	(	-LRB-
cord-006229-7yoilsho	1635	13	GPCRs	gpcr	NNS
cord-006229-7yoilsho	1635	14	)	)	-RRB-
cord-006229-7yoilsho	1635	15	belong	belong	VBP
cord-006229-7yoilsho	1635	16	to	to	IN
cord-006229-7yoilsho	1635	17	a	a	DT
cord-006229-7yoilsho	1635	18	superfamily	superfamily	NN
cord-006229-7yoilsho	1635	19	of	of	IN
cord-006229-7yoilsho	1635	20	cell	cell	NN
cord-006229-7yoilsho	1635	21	surface	surface	NN
cord-006229-7yoilsho	1635	22	signaling	signal	VBG
cord-006229-7yoilsho	1635	23	proteins	protein	NNS
cord-006229-7yoilsho	1635	24	that	that	WDT
cord-006229-7yoilsho	1635	25	mediate	mediate	VBP
cord-006229-7yoilsho	1635	26	many	many	JJ
cord-006229-7yoilsho	1635	27	physiological	physiological	JJ
cord-006229-7yoilsho	1635	28	responses	response	NNS
cord-006229-7yoilsho	1635	29	to	to	IN
cord-006229-7yoilsho	1635	30	hormones	hormone	NNS
cord-006229-7yoilsho	1635	31	and	and	CC
cord-006229-7yoilsho	1635	32	neurotransmitters	neurotransmitter	NNS
cord-006229-7yoilsho	1635	33	.	.	.
cord-006229-7yoilsho	1636	1	They	-PRON-	PRP
cord-006229-7yoilsho	1636	2	represent	represent	VBP
cord-006229-7yoilsho	1636	3	the	the	DT
cord-006229-7yoilsho	1636	4	prime	prime	JJ
cord-006229-7yoilsho	1636	5	targets	target	NNS
cord-006229-7yoilsho	1636	6	for	for	IN
cord-006229-7yoilsho	1636	7	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	1636	8	drugs	drug	NNS
cord-006229-7yoilsho	1636	9	in	in	IN
cord-006229-7yoilsho	1636	10	healthcare	healthcare	NN
cord-006229-7yoilsho	1636	11	.	.	.
cord-006229-7yoilsho	1637	1	However	however	RB
cord-006229-7yoilsho	1637	2	,	,	,
cord-006229-7yoilsho	1637	3	due	due	IN
cord-006229-7yoilsho	1637	4	to	to	IN
cord-006229-7yoilsho	1637	5	the	the	DT
cord-006229-7yoilsho	1637	6	limited	limited	JJ
cord-006229-7yoilsho	1637	7	knowledge	knowledge	NN
cord-006229-7yoilsho	1637	8	about	about	IN
cord-006229-7yoilsho	1637	9	the	the	DT
cord-006229-7yoilsho	1637	10	pharmacology	pharmacology	NN
cord-006229-7yoilsho	1637	11	of	of	IN
cord-006229-7yoilsho	1637	12	the	the	DT
cord-006229-7yoilsho	1637	13	majority	majority	NN
cord-006229-7yoilsho	1637	14	of	of	IN
cord-006229-7yoilsho	1637	15	GPCRs	gpcr	NNS
cord-006229-7yoilsho	1637	16	,	,	,
cord-006229-7yoilsho	1637	17	only	only	RB
cord-006229-7yoilsho	1637	18	few	few	JJ
cord-006229-7yoilsho	1637	19	of	of	IN
cord-006229-7yoilsho	1637	20	them	-PRON-	PRP
cord-006229-7yoilsho	1637	21	are	be	VBP
cord-006229-7yoilsho	1637	22	employed	employ	VBN
cord-006229-7yoilsho	1637	23	as	as	IN
cord-006229-7yoilsho	1637	24	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	1637	25	target	target	NN
cord-006229-7yoilsho	1637	26	.	.	.
cord-006229-7yoilsho	1638	1	In	in	IN
cord-006229-7yoilsho	1638	2	our	-PRON-	PRP$
cord-006229-7yoilsho	1638	3	lab	lab	NN
cord-006229-7yoilsho	1638	4	,	,	,
cord-006229-7yoilsho	1638	5	the	the	DT
cord-006229-7yoilsho	1638	6	activation	activation	NN
cord-006229-7yoilsho	1638	7	kinetics	kinetics	NN
cord-006229-7yoilsho	1638	8	of	of	IN
cord-006229-7yoilsho	1638	9	the	the	DT
cord-006229-7yoilsho	1638	10	α	α	NNP
cord-006229-7yoilsho	1638	11	2Aadrenergic	2aadrenergic	JJ
cord-006229-7yoilsho	1638	12	receptor	receptor	NN
cord-006229-7yoilsho	1638	13	,	,	,
cord-006229-7yoilsho	1638	14	among	among	IN
cord-006229-7yoilsho	1638	15	others	other	NNS
cord-006229-7yoilsho	1638	16	receptors	receptor	NNS
cord-006229-7yoilsho	1638	17	,	,	,
cord-006229-7yoilsho	1638	18	has	have	VBZ
cord-006229-7yoilsho	1638	19	been	be	VBN
cord-006229-7yoilsho	1638	20	extensively	extensively	RB
cord-006229-7yoilsho	1638	21	studied	study	VBN
cord-006229-7yoilsho	1638	22	in	in	IN
cord-006229-7yoilsho	1638	23	single	single	JJ
cord-006229-7yoilsho	1638	24	cell	cell	NN
cord-006229-7yoilsho	1638	25	assays	assay	NNS
cord-006229-7yoilsho	1638	26	(	(	-LRB-
cord-006229-7yoilsho	1638	27	1	1	CD
cord-006229-7yoilsho	1638	28	)	)	-RRB-
cord-006229-7yoilsho	1638	29	(	(	-LRB-
cord-006229-7yoilsho	1638	30	2	2	CD
cord-006229-7yoilsho	1638	31	)	)	-RRB-
cord-006229-7yoilsho	1638	32	.	.	.
cord-006229-7yoilsho	1639	1	The	the	DT
cord-006229-7yoilsho	1639	2	activation	activation	NN
cord-006229-7yoilsho	1639	3	kinetics	kinetics	NN
cord-006229-7yoilsho	1639	4	of	of	IN
cord-006229-7yoilsho	1639	5	the	the	DT
cord-006229-7yoilsho	1639	6	labeled	labeled	JJ
cord-006229-7yoilsho	1639	7	α	α	NNP
cord-006229-7yoilsho	1639	8	2A	2a	CD
cord-006229-7yoilsho	1639	9	-adrenergic	-adrenergic	NNP
cord-006229-7yoilsho	1639	10	were	be	VBD
cord-006229-7yoilsho	1639	11	monitored	monitor	VBN
cord-006229-7yoilsho	1639	12	by	by	IN
cord-006229-7yoilsho	1639	13	Förster	Förster	NNP
cord-006229-7yoilsho	1639	14	Resonance	Resonance	NNP
cord-006229-7yoilsho	1639	15	Energy	Energy	NNP
cord-006229-7yoilsho	1639	16	Transfer	Transfer	NNP
cord-006229-7yoilsho	1639	17	(	(	-LRB-
cord-006229-7yoilsho	1639	18	FRET	FRET	NNP
cord-006229-7yoilsho	1639	19	)	)	-RRB-
cord-006229-7yoilsho	1639	20	.	.	.
cord-006229-7yoilsho	1640	1	The	the	DT
cord-006229-7yoilsho	1640	2	goal	goal	NN
cord-006229-7yoilsho	1640	3	of	of	IN
cord-006229-7yoilsho	1640	4	our	-PRON-	PRP$
cord-006229-7yoilsho	1640	5	study	study	NN
cord-006229-7yoilsho	1640	6	is	be	VBZ
cord-006229-7yoilsho	1640	7	to	to	TO
cord-006229-7yoilsho	1640	8	design	design	VB
cord-006229-7yoilsho	1640	9	a	a	DT
cord-006229-7yoilsho	1640	10	sensor	sensor	NN
cord-006229-7yoilsho	1640	11	to	to	TO
cord-006229-7yoilsho	1640	12	monitor	monitor	VB
cord-006229-7yoilsho	1640	13	receptor	receptor	NN
cord-006229-7yoilsho	1640	14	activation	activation	NN
cord-006229-7yoilsho	1640	15	kinetics	kinetic	NNS
cord-006229-7yoilsho	1640	16	in	in	IN
cord-006229-7yoilsho	1640	17	high	high	JJ
cord-006229-7yoilsho	1640	18	throughput	throughput	NN
cord-006229-7yoilsho	1640	19	screening	screening	NN
cord-006229-7yoilsho	1640	20	assays	assay	NNS
cord-006229-7yoilsho	1640	21	.	.	.
cord-006229-7yoilsho	1641	1	For	for	IN
cord-006229-7yoilsho	1641	2	the	the	DT
cord-006229-7yoilsho	1641	3	proof	proof	NN
cord-006229-7yoilsho	1641	4	of	of	IN
cord-006229-7yoilsho	1641	5	concept	concept	NN
cord-006229-7yoilsho	1641	6	,	,	,
cord-006229-7yoilsho	1641	7	we	-PRON-	PRP
cord-006229-7yoilsho	1641	8	used	use	VBD
cord-006229-7yoilsho	1641	9	the	the	DT
cord-006229-7yoilsho	1641	10	α	α	NNP
cord-006229-7yoilsho	1641	11	2A	2a	CD
cord-006229-7yoilsho	1641	12	-adrenergic	-adrenergic	JJ
cord-006229-7yoilsho	1641	13	receptor	receptor	NN
cord-006229-7yoilsho	1641	14	as	as	IN
cord-006229-7yoilsho	1641	15	a	a	DT
cord-006229-7yoilsho	1641	16	prototype	prototype	NN
cord-006229-7yoilsho	1641	17	.	.	.
cord-006229-7yoilsho	1642	1	To	to	TO
cord-006229-7yoilsho	1642	2	optimize	optimize	VB
cord-006229-7yoilsho	1642	3	the	the	DT
cord-006229-7yoilsho	1642	4	FRET	fret	NN
cord-006229-7yoilsho	1642	5	efficiency	efficiency	NN
cord-006229-7yoilsho	1642	6	we	-PRON-	PRP
cord-006229-7yoilsho	1642	7	exchanged	exchange	VBD
cord-006229-7yoilsho	1642	8	the	the	DT
cord-006229-7yoilsho	1642	9	previous	previous	JJ
cord-006229-7yoilsho	1642	10	acceptor	acceptor	NN
cord-006229-7yoilsho	1642	11	(	(	-LRB-
cord-006229-7yoilsho	1642	12	YFP	YFP	NNP
cord-006229-7yoilsho	1642	13	)	)	-RRB-
cord-006229-7yoilsho	1642	14	with	with	IN
cord-006229-7yoilsho	1642	15	the	the	DT
cord-006229-7yoilsho	1642	16	HaloTag	HaloTag	NNP
cord-006229-7yoilsho	1642	17	technology	technology	NN
cord-006229-7yoilsho	1642	18	(	(	-LRB-
cord-006229-7yoilsho	1642	19	3	3	CD
cord-006229-7yoilsho	1642	20	)	)	-RRB-
cord-006229-7yoilsho	1642	21	.	.	.
cord-006229-7yoilsho	1643	1	Additionally	additionally	RB
cord-006229-7yoilsho	1643	2	,	,	,
cord-006229-7yoilsho	1643	3	we	-PRON-	PRP
cord-006229-7yoilsho	1643	4	used	use	VBD
cord-006229-7yoilsho	1643	5	HaloTag	HaloTag	NNP
cord-006229-7yoilsho	1643	6	in	in	IN
cord-006229-7yoilsho	1643	7	combination	combination	NN
cord-006229-7yoilsho	1643	8	with	with	IN
cord-006229-7yoilsho	1643	9	the	the	DT
cord-006229-7yoilsho	1643	10	NanoLuc	NanoLuc	NNP
cord-006229-7yoilsho	1643	11	(	(	-LRB-
cord-006229-7yoilsho	1643	12	4	4	CD
cord-006229-7yoilsho	1643	13	)	)	-RRB-
cord-006229-7yoilsho	1643	14	to	to	TO
cord-006229-7yoilsho	1643	15	explore	explore	VB
cord-006229-7yoilsho	1643	16	the	the	DT
cord-006229-7yoilsho	1643	17	possibility	possibility	NN
cord-006229-7yoilsho	1643	18	of	of	IN
cord-006229-7yoilsho	1643	19	using	use	VBG
cord-006229-7yoilsho	1643	20	BRET	BRET	NNP
cord-006229-7yoilsho	1643	21	as	as	IN
cord-006229-7yoilsho	1643	22	a	a	DT
cord-006229-7yoilsho	1643	23	high	high	JJ
cord-006229-7yoilsho	1643	24	-	-	HYPH
cord-006229-7yoilsho	1643	25	throughput	throughput	NN
cord-006229-7yoilsho	1643	26	approach	approach	NN
cord-006229-7yoilsho	1643	27	to	to	TO
cord-006229-7yoilsho	1643	28	monitor	monitor	VB
cord-006229-7yoilsho	1643	29	receptor	receptor	NN
cord-006229-7yoilsho	1643	30	activation	activation	NN
cord-006229-7yoilsho	1643	31	kinetics	kinetic	NNS
cord-006229-7yoilsho	1643	32	.	.	.
cord-006229-7yoilsho	1644	1	The	the	DT
cord-006229-7yoilsho	1644	2	FRET	fret	NN
cord-006229-7yoilsho	1644	3	-	-	HYPH
cord-006229-7yoilsho	1644	4	based	base	VBN
cord-006229-7yoilsho	1644	5	sensor	sensor	NN
cord-006229-7yoilsho	1645	1	α	α	NNP
cord-006229-7yoilsho	1645	2	2A	2A	NNP
cord-006229-7yoilsho	1645	3	-Halo	-Halo	NNP
cord-006229-7yoilsho	1645	4	/	/	SYM
cord-006229-7yoilsho	1645	5	CFP	CFP	NNP
cord-006229-7yoilsho	1645	6	showed	show	VBD
cord-006229-7yoilsho	1645	7	an	an	DT
cord-006229-7yoilsho	1645	8	increase	increase	NN
cord-006229-7yoilsho	1645	9	in	in	IN
cord-006229-7yoilsho	1645	10	FRET	fret	NN
cord-006229-7yoilsho	1645	11	upon	upon	IN
cord-006229-7yoilsho	1645	12	application	application	NN
cord-006229-7yoilsho	1645	13	of	of	IN
cord-006229-7yoilsho	1645	14	the	the	DT
cord-006229-7yoilsho	1645	15	full	full	JJ
cord-006229-7yoilsho	1645	16	endogenous	endogenous	JJ
cord-006229-7yoilsho	1645	17	agonist	agonist	NN
cord-006229-7yoilsho	1645	18	norepinephrine	norepinephrine	NN
cord-006229-7yoilsho	1645	19	with	with	IN
cord-006229-7yoilsho	1645	20	an	an	DT
cord-006229-7yoilsho	1645	21	EC50	EC50	NNP
cord-006229-7yoilsho	1645	22	value	value	NN
cord-006229-7yoilsho	1645	23	in	in	IN
cord-006229-7yoilsho	1645	24	accordance	accordance	NN
cord-006229-7yoilsho	1645	25	with	with	IN
cord-006229-7yoilsho	1645	26	the	the	DT
cord-006229-7yoilsho	1645	27	previously	previously	RB
cord-006229-7yoilsho	1645	28	published	publish	VBN
cord-006229-7yoilsho	1645	29	data	datum	NNS
cord-006229-7yoilsho	1645	30	.	.	.
cord-006229-7yoilsho	1646	1	This	this	DT
cord-006229-7yoilsho	1646	2	suggests	suggest	VBZ
cord-006229-7yoilsho	1646	3	the	the	DT
cord-006229-7yoilsho	1646	4	functionality	functionality	NN
cord-006229-7yoilsho	1646	5	of	of	IN
cord-006229-7yoilsho	1646	6	the	the	DT
cord-006229-7yoilsho	1646	7	FRET	fret	NN
cord-006229-7yoilsho	1646	8	-	-	HYPH
cord-006229-7yoilsho	1646	9	based	base	VBN
cord-006229-7yoilsho	1646	10	α	α	NN
cord-006229-7yoilsho	1646	11	2A	2a	CD
cord-006229-7yoilsho	1646	12	-Halo	-Halo	NNP
cord-006229-7yoilsho	1646	13	/	/	SYM
cord-006229-7yoilsho	1646	14	CFP	CFP	NNP
cord-006229-7yoilsho	1646	15	sensor	sensor	NN
cord-006229-7yoilsho	1646	16	.	.	.
cord-006229-7yoilsho	1647	1	Similar	similar	JJ
cord-006229-7yoilsho	1647	2	results	result	NNS
cord-006229-7yoilsho	1647	3	were	be	VBD
cord-006229-7yoilsho	1647	4	obtained	obtain	VBN
cord-006229-7yoilsho	1647	5	with	with	IN
cord-006229-7yoilsho	1647	6	the	the	DT
cord-006229-7yoilsho	1647	7	α	α	NNP
cord-006229-7yoilsho	1647	8	2A	2a	CD
cord-006229-7yoilsho	1647	9	-adrenergic	-adrenergic	JJ
cord-006229-7yoilsho	1647	10	receptor	receptor	NN
cord-006229-7yoilsho	1647	11	BRET	BRET	NNP
cord-006229-7yoilsho	1647	12	-	-	HYPH
cord-006229-7yoilsho	1647	13	based	base	VBN
cord-006229-7yoilsho	1647	14	sensor	sensor	NN
cord-006229-7yoilsho	1647	15	.	.	.
cord-006229-7yoilsho	1648	1	In	in	IN
cord-006229-7yoilsho	1648	2	contrast	contrast	NN
cord-006229-7yoilsho	1648	3	to	to	IN
cord-006229-7yoilsho	1648	4	the	the	DT
cord-006229-7yoilsho	1648	5	full	full	JJ
cord-006229-7yoilsho	1648	6	agonist	agonist	NN
cord-006229-7yoilsho	1648	7	norepinephrine	norepinephrine	NN
cord-006229-7yoilsho	1648	8	,	,	,
cord-006229-7yoilsho	1648	9	the	the	DT
cord-006229-7yoilsho	1648	10	inverse	inverse	JJ
cord-006229-7yoilsho	1648	11	agonist	agonist	NN
cord-006229-7yoilsho	1648	12	,	,	,
cord-006229-7yoilsho	1648	13	Yohimbine	Yohimbine	NNP
cord-006229-7yoilsho	1648	14	,	,	,
cord-006229-7yoilsho	1648	15	decreased	decrease	VBD
cord-006229-7yoilsho	1648	16	the	the	DT
cord-006229-7yoilsho	1648	17	ratio	ratio	NN
cord-006229-7yoilsho	1648	18	in	in	IN
cord-006229-7yoilsho	1648	19	both	both	DT
cord-006229-7yoilsho	1648	20	,	,	,
cord-006229-7yoilsho	1648	21	FRET	fret	VB
cord-006229-7yoilsho	1648	22	as	as	RB
cord-006229-7yoilsho	1648	23	well	well	RB
cord-006229-7yoilsho	1648	24	as	as	IN
cord-006229-7yoilsho	1648	25	BRET	BRET	NNP
cord-006229-7yoilsho	1648	26	-	-	HYPH
cord-006229-7yoilsho	1648	27	based	base	VBN
cord-006229-7yoilsho	1648	28	α	α	NNP
cord-006229-7yoilsho	1648	29	2Aadrenergic	2aadrenergic	JJ
cord-006229-7yoilsho	1648	30	receptor	receptor	NN
cord-006229-7yoilsho	1648	31	sensors	sensor	NNS
cord-006229-7yoilsho	1648	32	.	.	.
cord-006229-7yoilsho	1649	1	This	this	DT
cord-006229-7yoilsho	1649	2	suggests	suggest	VBZ
cord-006229-7yoilsho	1649	3	the	the	DT
cord-006229-7yoilsho	1649	4	sensitivity	sensitivity	NN
cord-006229-7yoilsho	1649	5	of	of	IN
cord-006229-7yoilsho	1649	6	the	the	DT
cord-006229-7yoilsho	1649	7	methods	method	NNS
cord-006229-7yoilsho	1649	8	to	to	TO
cord-006229-7yoilsho	1649	9	discriminate	discriminate	VB
cord-006229-7yoilsho	1649	10	among	among	IN
cord-006229-7yoilsho	1649	11	agonist	agonist	NN
cord-006229-7yoilsho	1649	12	(	(	-LRB-
cord-006229-7yoilsho	1649	13	increased	increase	VBN
cord-006229-7yoilsho	1649	14	ratio	ratio	NN
cord-006229-7yoilsho	1649	15	)	)	-RRB-
cord-006229-7yoilsho	1649	16	and	and	CC
cord-006229-7yoilsho	1649	17	antagonist	antagonist	NN
cord-006229-7yoilsho	1649	18	(	(	-LRB-
cord-006229-7yoilsho	1649	19	decreased	decreased	JJ
cord-006229-7yoilsho	1649	20	ratio	ratio	NN
cord-006229-7yoilsho	1649	21	)	)	-RRB-
cord-006229-7yoilsho	1649	22	induced	induce	VBN
cord-006229-7yoilsho	1649	23	receptor	receptor	NN
cord-006229-7yoilsho	1649	24	kinetics	kinetic	NNS
cord-006229-7yoilsho	1649	25	.	.	.
cord-006229-7yoilsho	1650	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	1650	2	results	result	NNS
cord-006229-7yoilsho	1650	3	show	show	VBP
cord-006229-7yoilsho	1650	4	the	the	DT
cord-006229-7yoilsho	1650	5	feasibility	feasibility	NN
cord-006229-7yoilsho	1650	6	of	of	IN
cord-006229-7yoilsho	1650	7	using	use	VBG
cord-006229-7yoilsho	1650	8	HaloTag	HaloTag	NNP
cord-006229-7yoilsho	1650	9	to	to	TO
cord-006229-7yoilsho	1650	10	monitor	monitor	VB
cord-006229-7yoilsho	1650	11	receptor	receptor	NN
cord-006229-7yoilsho	1650	12	activation	activation	NN
cord-006229-7yoilsho	1650	13	via	via	IN
cord-006229-7yoilsho	1650	14	FRET	fret	NN
cord-006229-7yoilsho	1650	15	in	in	IN
cord-006229-7yoilsho	1650	16	a	a	DT
cord-006229-7yoilsho	1650	17	single	single	JJ
cord-006229-7yoilsho	1650	18	cells	cell	NNS
cord-006229-7yoilsho	1650	19	format	format	NN
cord-006229-7yoilsho	1650	20	and	and	CC
cord-006229-7yoilsho	1650	21	HaloTag	HaloTag	NNP
cord-006229-7yoilsho	1650	22	,	,	,
cord-006229-7yoilsho	1650	23	in	in	IN
cord-006229-7yoilsho	1650	24	combination	combination	NN
cord-006229-7yoilsho	1650	25	with	with	IN
cord-006229-7yoilsho	1650	26	NanoLuc	NanoLuc	NNP
cord-006229-7yoilsho	1650	27	,	,	,
cord-006229-7yoilsho	1650	28	can	can	MD
cord-006229-7yoilsho	1650	29	be	be	VB
cord-006229-7yoilsho	1650	30	used	use	VBN
cord-006229-7yoilsho	1650	31	to	to	TO
cord-006229-7yoilsho	1650	32	monitor	monitor	VB
cord-006229-7yoilsho	1650	33	receptor	receptor	NN
cord-006229-7yoilsho	1650	34	activation	activation	NN
cord-006229-7yoilsho	1650	35	in	in	IN
cord-006229-7yoilsho	1650	36	high	high	JJ
cord-006229-7yoilsho	1650	37	-	-	HYPH
cord-006229-7yoilsho	1650	38	throughput	throughput	NN
cord-006229-7yoilsho	1650	39	format	format	NN
cord-006229-7yoilsho	1650	40	.	.	.
cord-006229-7yoilsho	1651	1	,	,	,
cord-006229-7yoilsho	1651	2	C.	C.	NNP
cord-006229-7yoilsho	1651	3	Hoffmann	Hoffmann	NNP
cord-006229-7yoilsho	1651	4	the	the	DT
cord-006229-7yoilsho	1651	5	homologous	homologous	JJ
cord-006229-7yoilsho	1651	6	visual	visual	JJ
cord-006229-7yoilsho	1651	7	arrestins	arrestin	NNS
cord-006229-7yoilsho	1651	8	)	)	-RRB-
cord-006229-7yoilsho	1651	9	that	that	WDT
cord-006229-7yoilsho	1651	10	has	have	VBZ
cord-006229-7yoilsho	1651	11	recently	recently	RB
cord-006229-7yoilsho	1651	12	been	be	VBN
cord-006229-7yoilsho	1651	13	solved	solve	VBN
cord-006229-7yoilsho	1651	14	by	by	IN
cord-006229-7yoilsho	1651	15	X	x	NN
cord-006229-7yoilsho	1651	16	-	-	NN
cord-006229-7yoilsho	1651	17	ray	ray	NN
cord-006229-7yoilsho	1651	18	crystallography	crystallography	NN
cord-006229-7yoilsho	1651	19	.	.	.
cord-006229-7yoilsho	1652	1	Here	here	RB
cord-006229-7yoilsho	1652	2	we	-PRON-	PRP
cord-006229-7yoilsho	1652	3	investigated	investigate	VBD
cord-006229-7yoilsho	1652	4	both	both	CC
cord-006229-7yoilsho	1652	5	the	the	DT
cord-006229-7yoilsho	1652	6	interaction	interaction	NN
cord-006229-7yoilsho	1652	7	with	with	IN
cord-006229-7yoilsho	1652	8	GPCRs	gpcr	NNS
cord-006229-7yoilsho	1652	9	and	and	CC
cord-006229-7yoilsho	1652	10	β	β	NN
cord-006229-7yoilsho	1652	11	-	-	HYPH
cord-006229-7yoilsho	1652	12	arrestin	arrestin	JJ
cord-006229-7yoilsho	1652	13	conformational	conformational	JJ
cord-006229-7yoilsho	1652	14	changes	change	NNS
cord-006229-7yoilsho	1652	15	in	in	IN
cord-006229-7yoilsho	1652	16	real	real	JJ
cord-006229-7yoilsho	1652	17	time	time	NN
cord-006229-7yoilsho	1652	18	and	and	CC
cord-006229-7yoilsho	1652	19	in	in	IN
cord-006229-7yoilsho	1652	20	living	live	VBG
cord-006229-7yoilsho	1652	21	cells	cell	NNS
cord-006229-7yoilsho	1652	22	with	with	IN
cord-006229-7yoilsho	1652	23	a	a	DT
cord-006229-7yoilsho	1652	24	series	series	NN
cord-006229-7yoilsho	1652	25	of	of	IN
cord-006229-7yoilsho	1652	26	FRET	fret	NN
cord-006229-7yoilsho	1652	27	-	-	HYPH
cord-006229-7yoilsho	1652	28	based	base	VBN
cord-006229-7yoilsho	1652	29	β	β	NN
cord-006229-7yoilsho	1652	30	-	-	HYPH
cord-006229-7yoilsho	1652	31	arrestin2	arrestin2	NN
cord-006229-7yoilsho	1652	32	biosensors	biosensor	NNS
cord-006229-7yoilsho	1652	33	.	.	.
cord-006229-7yoilsho	1653	1	Upon	upon	IN
cord-006229-7yoilsho	1653	2	stimulation	stimulation	NN
cord-006229-7yoilsho	1653	3	,	,	,
cord-006229-7yoilsho	1653	4	β2-adrenergic	β2-adrenergic	JJ
cord-006229-7yoilsho	1653	5	receptors	receptor	NNS
cord-006229-7yoilsho	1653	6	bound	bind	VBD
cord-006229-7yoilsho	1653	7	β	β	NN
cord-006229-7yoilsho	1653	8	-	-	HYPH
cord-006229-7yoilsho	1653	9	arrestin2	arrestin2	NN
cord-006229-7yoilsho	1653	10	with	with	IN
cord-006229-7yoilsho	1653	11	a	a	DT
cord-006229-7yoilsho	1653	12	time	time	NN
cord-006229-7yoilsho	1653	13	constant	constant	JJ
cord-006229-7yoilsho	1653	14	τ	τ	NN
cord-006229-7yoilsho	1653	15	=	=	NFP
cord-006229-7yoilsho	1654	1	1.3	1.3	CD
cord-006229-7yoilsho	1654	2	±	±	CD
cord-006229-7yoilsho	1654	3	0.17	0.17	CC
cord-006229-7yoilsho	1654	4	s	s	NNP
cord-006229-7yoilsho	1654	5	,	,	,
cord-006229-7yoilsho	1654	6	indicating	indicate	VBG
cord-006229-7yoilsho	1654	7	that	that	IN
cord-006229-7yoilsho	1654	8	β	β	NN
cord-006229-7yoilsho	1654	9	-	-	HYPH
cord-006229-7yoilsho	1654	10	arrestin2	arrestin2	NN
cord-006229-7yoilsho	1654	11	binding	bind	VBG
cord-006229-7yoilsho	1654	12	rapidly	rapidly	RB
cord-006229-7yoilsho	1654	13	terminates	terminate	VBZ
cord-006229-7yoilsho	1654	14	their	-PRON-	PRP$
cord-006229-7yoilsho	1654	15	Gprotein	Gprotein	NNP
cord-006229-7yoilsho	1654	16	signaling	signal	VBG
cord-006229-7yoilsho	1654	17	.	.	.
cord-006229-7yoilsho	1655	1	We	-PRON-	PRP
cord-006229-7yoilsho	1655	2	observed	observe	VBD
cord-006229-7yoilsho	1655	3	a	a	DT
cord-006229-7yoilsho	1655	4	subsequent	subsequent	JJ
cord-006229-7yoilsho	1655	5	receptor	receptor	NN
cord-006229-7yoilsho	1655	6	-	-	HYPH
cord-006229-7yoilsho	1655	7	mediated	mediate	VBN
cord-006229-7yoilsho	1655	8	conformational	conformational	JJ
cord-006229-7yoilsho	1655	9	change	change	NN
cord-006229-7yoilsho	1655	10	in	in	IN
cord-006229-7yoilsho	1655	11	β	β	NN
cord-006229-7yoilsho	1655	12	-	-	HYPH
cord-006229-7yoilsho	1655	13	arrestin2	arrestin2	NN
cord-006229-7yoilsho	1655	14	with	with	IN
cord-006229-7yoilsho	1655	15	a	a	DT
cord-006229-7yoilsho	1655	16	τ	τ	NN
cord-006229-7yoilsho	1655	17	=	=	NFP
cord-006229-7yoilsho	1656	1	2.2	2.2	CD
cord-006229-7yoilsho	1656	2	±	±	CD
cord-006229-7yoilsho	1656	3	0.22	0.22	CD
cord-006229-7yoilsho	1656	4	s.	s.	NNP
cord-006229-7yoilsho	1656	5	Stimulation	stimulation	NN
cord-006229-7yoilsho	1656	6	of	of	IN
cord-006229-7yoilsho	1656	7	β2-adrenergic	β2-adrenergic	NNP
cord-006229-7yoilsho	1656	8	vs.	vs.	FW
cord-006229-7yoilsho	1656	9	M2	m2	JJ
cord-006229-7yoilsho	1656	10	muscarinic	muscarinic	NN
cord-006229-7yoilsho	1656	11	or	or	CC
cord-006229-7yoilsho	1656	12	FFA4	FFA4	NNP
cord-006229-7yoilsho	1656	13	receptors	receptor	NNS
cord-006229-7yoilsho	1656	14	resulted	result	VBD
cord-006229-7yoilsho	1656	15	in	in	IN
cord-006229-7yoilsho	1656	16	different	different	JJ
cord-006229-7yoilsho	1656	17	patterns	pattern	NNS
cord-006229-7yoilsho	1656	18	of	of	IN
cord-006229-7yoilsho	1656	19	conformational	conformational	JJ
cord-006229-7yoilsho	1656	20	changes	change	NNS
cord-006229-7yoilsho	1656	21	in	in	IN
cord-006229-7yoilsho	1656	22	the	the	DT
cord-006229-7yoilsho	1656	23	various	various	JJ
cord-006229-7yoilsho	1656	24	β	β	NN
cord-006229-7yoilsho	1656	25	-	-	HYPH
cord-006229-7yoilsho	1656	26	arrestin2	arrestin2	NN
cord-006229-7yoilsho	1656	27	sensors	sensor	NNS
cord-006229-7yoilsho	1656	28	and	and	CC
cord-006229-7yoilsho	1656	29	also	also	RB
cord-006229-7yoilsho	1656	30	in	in	IN
cord-006229-7yoilsho	1656	31	downstream	downstream	JJ
cord-006229-7yoilsho	1656	32	kinase	kinase	NN
cord-006229-7yoilsho	1656	33	signaling	signal	VBG
cord-006229-7yoilsho	1656	34	,	,	,
cord-006229-7yoilsho	1656	35	revealing	reveal	VBG
cord-006229-7yoilsho	1656	36	receptor	receptor	NN
cord-006229-7yoilsho	1656	37	-	-	HYPH
cord-006229-7yoilsho	1656	38	specificity	specificity	NN
cord-006229-7yoilsho	1656	39	in	in	IN
cord-006229-7yoilsho	1656	40	β	β	NN
cord-006229-7yoilsho	1656	41	-	-	HYPH
cord-006229-7yoilsho	1656	42	arrestin2	arrestin2	NN
cord-006229-7yoilsho	1656	43	activation	activation	NN
cord-006229-7yoilsho	1656	44	.	.	.
cord-006229-7yoilsho	1657	1	Upon	upon	IN
cord-006229-7yoilsho	1657	2	agonist	agonist	NN
cord-006229-7yoilsho	1657	3	removal	removal	NN
cord-006229-7yoilsho	1657	4	,	,	,
cord-006229-7yoilsho	1657	5	first	first	RB
cord-006229-7yoilsho	1657	6	the	the	DT
cord-006229-7yoilsho	1657	7	interaction	interaction	NN
cord-006229-7yoilsho	1657	8	(	(	-LRB-
cord-006229-7yoilsho	1657	9	delay	delay	NN
cord-006229-7yoilsho	1657	10	=	=	SYM
cord-006229-7yoilsho	1657	11	1.9	1.9	CD
cord-006229-7yoilsho	1657	12	±	±	CD
cord-006229-7yoilsho	1657	13	0.51	0.51	CD
cord-006229-7yoilsho	1657	14	s	s	NNPS
cord-006229-7yoilsho	1657	15	)	)	-RRB-
cord-006229-7yoilsho	1657	16	and	and	CC
cord-006229-7yoilsho	1657	17	only	only	RB
cord-006229-7yoilsho	1657	18	then	then	RB
cord-006229-7yoilsho	1657	19	the	the	DT
cord-006229-7yoilsho	1657	20	active	active	JJ
cord-006229-7yoilsho	1657	21	state	state	NN
cord-006229-7yoilsho	1657	22	of	of	IN
cord-006229-7yoilsho	1657	23	β	β	NN
cord-006229-7yoilsho	1657	24	-	-	HYPH
cord-006229-7yoilsho	1657	25	arrestin2	arrestin2	NN
cord-006229-7yoilsho	1657	26	(	(	-LRB-
cord-006229-7yoilsho	1657	27	delay	delay	NN
cord-006229-7yoilsho	1657	28	=	=	SYM
cord-006229-7yoilsho	1657	29	4.2	4.2	CD
cord-006229-7yoilsho	1657	30	±	±	CD
cord-006229-7yoilsho	1657	31	0.85	0.85	CD
cord-006229-7yoilsho	1657	32	s	s	NNPS
cord-006229-7yoilsho	1657	33	)	)	-RRB-
cord-006229-7yoilsho	1657	34	were	be	VBD
cord-006229-7yoilsho	1657	35	reversed	reverse	VBN
cord-006229-7yoilsho	1657	36	.	.	.
cord-006229-7yoilsho	1658	1	Accordingly	accordingly	RB
cord-006229-7yoilsho	1658	2	,	,	,
cord-006229-7yoilsho	1658	3	β	β	LS
cord-006229-7yoilsho	1658	4	-	-	HYPH
cord-006229-7yoilsho	1658	5	arrestin	arrestin	JJ
cord-006229-7yoilsho	1658	6	localization	localization	NN
cord-006229-7yoilsho	1658	7	at	at	IN
cord-006229-7yoilsho	1658	8	the	the	DT
cord-006229-7yoilsho	1658	9	cell	cell	NN
cord-006229-7yoilsho	1658	10	membrane	membrane	NN
cord-006229-7yoilsho	1658	11	lasted	last	VBD
cord-006229-7yoilsho	1658	12	much	much	RB
cord-006229-7yoilsho	1658	13	longer	long	RBR
cord-006229-7yoilsho	1658	14	than	than	IN
cord-006229-7yoilsho	1658	15	the	the	DT
cord-006229-7yoilsho	1658	16	direct	direct	JJ
cord-006229-7yoilsho	1658	17	interaction	interaction	NN
cord-006229-7yoilsho	1658	18	with	with	IN
cord-006229-7yoilsho	1658	19	β2-adrenergic	β2-adrenergic	JJ
cord-006229-7yoilsho	1658	20	receptors	receptor	NNS
cord-006229-7yoilsho	1658	21	.	.	.
cord-006229-7yoilsho	1659	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	1659	2	data	datum	NNS
cord-006229-7yoilsho	1659	3	indicate	indicate	VBP
cord-006229-7yoilsho	1659	4	a	a	DT
cord-006229-7yoilsho	1659	5	rapid	rapid	JJ
cord-006229-7yoilsho	1659	6	,	,	,
cord-006229-7yoilsho	1659	7	receptorspecific	receptorspecific	NNP
cord-006229-7yoilsho	1659	8	,	,	,
cord-006229-7yoilsho	1659	9	two	two	CD
cord-006229-7yoilsho	1659	10	step	step	NN
cord-006229-7yoilsho	1659	11	binding	binding	NN
cord-006229-7yoilsho	1659	12	and	and	CC
cord-006229-7yoilsho	1659	13	activation	activation	NN
cord-006229-7yoilsho	1659	14	process	process	NN
cord-006229-7yoilsho	1659	15	between	between	IN
cord-006229-7yoilsho	1659	16	GPCRs	gpcr	NNS
cord-006229-7yoilsho	1659	17	and	and	CC
cord-006229-7yoilsho	1659	18	β	β	NN
cord-006229-7yoilsho	1659	19	-	-	HYPH
cord-006229-7yoilsho	1659	20	arrestins	arrestin	NNS
cord-006229-7yoilsho	1659	21	;	;	:
cord-006229-7yoilsho	1659	22	they	-PRON-	PRP
cord-006229-7yoilsho	1659	23	further	further	RB
cord-006229-7yoilsho	1659	24	suggest	suggest	VBP
cord-006229-7yoilsho	1659	25	that	that	IN
cord-006229-7yoilsho	1659	26	β	β	NN
cord-006229-7yoilsho	1659	27	-	-	HYPH
cord-006229-7yoilsho	1659	28	arrestins	arrestin	NNS
cord-006229-7yoilsho	1659	29	remain	remain	VBP
cord-006229-7yoilsho	1659	30	active	active	JJ
cord-006229-7yoilsho	1659	31	following	follow	VBG
cord-006229-7yoilsho	1659	32	dissociation	dissociation	NN
cord-006229-7yoilsho	1659	33	from	from	IN
cord-006229-7yoilsho	1659	34	receptors	receptor	NNS
cord-006229-7yoilsho	1659	35	,	,	,
cord-006229-7yoilsho	1659	36	allowing	allow	VBG
cord-006229-7yoilsho	1659	37	them	-PRON-	PRP
cord-006229-7yoilsho	1659	38	to	to	TO
cord-006229-7yoilsho	1659	39	remain	remain	VB
cord-006229-7yoilsho	1659	40	at	at	IN
cord-006229-7yoilsho	1659	41	the	the	DT
cord-006229-7yoilsho	1659	42	cell	cell	NN
cord-006229-7yoilsho	1659	43	surface	surface	NN
cord-006229-7yoilsho	1659	44	and	and	CC
cord-006229-7yoilsho	1659	45	presumably	presumably	RB
cord-006229-7yoilsho	1659	46	signal	signal	VB
cord-006229-7yoilsho	1659	47	independently	independently	RB
cord-006229-7yoilsho	1659	48	.	.	.
cord-006229-7yoilsho	1660	1	Thus	thus	RB
cord-006229-7yoilsho	1660	2	,	,	,
cord-006229-7yoilsho	1660	3	GPCRs	gpcr	NNS
cord-006229-7yoilsho	1660	4	trigger	trigger	VBP
cord-006229-7yoilsho	1660	5	a	a	DT
cord-006229-7yoilsho	1660	6	rapid	rapid	JJ
cord-006229-7yoilsho	1660	7	,	,	,
cord-006229-7yoilsho	1660	8	receptor	receptor	NN
cord-006229-7yoilsho	1660	9	-	-	HYPH
cord-006229-7yoilsho	1660	10	specific	specific	JJ
cord-006229-7yoilsho	1660	11	activation	activation	NN
cord-006229-7yoilsho	1660	12	/	/	SYM
cord-006229-7yoilsho	1660	13	deactivation	deactivation	NN
cord-006229-7yoilsho	1660	14	cycle	cycle	NN
cord-006229-7yoilsho	1660	15	of	of	IN
cord-006229-7yoilsho	1660	16	β	β	NN
cord-006229-7yoilsho	1660	17	-	-	HYPH
cord-006229-7yoilsho	1660	18	arrestins	arrestin	NNS
cord-006229-7yoilsho	1660	19	,	,	,
cord-006229-7yoilsho	1660	20	which	which	WDT
cord-006229-7yoilsho	1660	21	permits	permit	VBZ
cord-006229-7yoilsho	1660	22	their	-PRON-	PRP$
cord-006229-7yoilsho	1660	23	active	active	JJ
cord-006229-7yoilsho	1660	24	signaling	signaling	NN
cord-006229-7yoilsho	1660	25	.	.	.
cord-006229-7yoilsho	1661	1	Patghogenic	patghogenic	JJ
cord-006229-7yoilsho	1661	2	Clostridium	clostridium	NN
cord-006229-7yoilsho	1661	3	difficile	difficile	NN
cord-006229-7yoilsho	1661	4	produce	produce	VBP
cord-006229-7yoilsho	1661	5	two	two	CD
cord-006229-7yoilsho	1661	6	large	large	JJ
cord-006229-7yoilsho	1661	7	glucosyltransferases	glucosyltransferase	NNS
cord-006229-7yoilsho	1661	8	,	,	,
cord-006229-7yoilsho	1661	9	TcdA	TcdA	NNP
cord-006229-7yoilsho	1661	10	and	and	CC
cord-006229-7yoilsho	1661	11	TcdB	TcdB	NNP
cord-006229-7yoilsho	1661	12	,	,	,
cord-006229-7yoilsho	1661	13	which	which	WDT
cord-006229-7yoilsho	1661	14	are	be	VBP
cord-006229-7yoilsho	1661	15	the	the	DT
cord-006229-7yoilsho	1661	16	main	main	JJ
cord-006229-7yoilsho	1661	17	pathogenicity	pathogenicity	NN
cord-006229-7yoilsho	1661	18	factors	factor	NNS
cord-006229-7yoilsho	1661	19	.	.	.
cord-006229-7yoilsho	1662	1	The	the	DT
cord-006229-7yoilsho	1662	2	cytotoxin	cytotoxin	NN
cord-006229-7yoilsho	1662	3	TcdB	TcdB	NNP
cord-006229-7yoilsho	1662	4	is	be	VBZ
cord-006229-7yoilsho	1662	5	about	about	RB
cord-006229-7yoilsho	1662	6	1,000	1,000	CD
cord-006229-7yoilsho	1662	7	fold	fold	VB
cord-006229-7yoilsho	1662	8	more	more	RBR
cord-006229-7yoilsho	1662	9	potent	potent	JJ
cord-006229-7yoilsho	1662	10	than	than	IN
cord-006229-7yoilsho	1662	11	TcdA.	TcdA.	NNP
cord-006229-7yoilsho	1663	1	TcdA	TcdA	NNP
cord-006229-7yoilsho	1663	2	and	and	CC
cord-006229-7yoilsho	1663	3	TcdB	TcdB	NNP
cord-006229-7yoilsho	1663	4	are	be	VBP
cord-006229-7yoilsho	1663	5	A	A	NNP
cord-006229-7yoilsho	1663	6	/	/	SYM
cord-006229-7yoilsho	1663	7	B	b	NN
cord-006229-7yoilsho	1663	8	structure	structure	NN
cord-006229-7yoilsho	1663	9	toxins	toxin	NNS
cord-006229-7yoilsho	1663	10	exhibiting	exhibit	VBG
cord-006229-7yoilsho	1663	11	an	an	DT
cord-006229-7yoilsho	1663	12	enzymatically	enzymatically	RB
cord-006229-7yoilsho	1663	13	active	active	JJ
cord-006229-7yoilsho	1663	14	(	(	-LRB-
cord-006229-7yoilsho	1663	15	A	a	NN
cord-006229-7yoilsho	1663	16	)	)	-RRB-
cord-006229-7yoilsho	1663	17	domain	domain	NN
cord-006229-7yoilsho	1663	18	and	and	CC
cord-006229-7yoilsho	1663	19	a	a	DT
cord-006229-7yoilsho	1663	20	binding	binding	NN
cord-006229-7yoilsho	1663	21	/	/	SYM
cord-006229-7yoilsho	1663	22	translocation	translocation	NN
cord-006229-7yoilsho	1663	23	domain	domain	NN
cord-006229-7yoilsho	1663	24	(	(	-LRB-
cord-006229-7yoilsho	1663	25	B	b	NN
cord-006229-7yoilsho	1663	26	)	)	-RRB-
cord-006229-7yoilsho	1663	27	to	to	TO
cord-006229-7yoilsho	1663	28	deliver	deliver	VB
cord-006229-7yoilsho	1663	29	the	the	DT
cord-006229-7yoilsho	1663	30	active	active	JJ
cord-006229-7yoilsho	1663	31	glucosyltransferase	glucosyltransferase	NN
cord-006229-7yoilsho	1663	32	domain	domain	NN
cord-006229-7yoilsho	1663	33	into	into	IN
cord-006229-7yoilsho	1663	34	the	the	DT
cord-006229-7yoilsho	1663	35	cytosol	cytosol	NN
cord-006229-7yoilsho	1663	36	of	of	IN
cord-006229-7yoilsho	1663	37	host	host	NN
cord-006229-7yoilsho	1663	38	cells	cell	NNS
cord-006229-7yoilsho	1663	39	.	.	.
cord-006229-7yoilsho	1664	1	Beside	beside	IN
cord-006229-7yoilsho	1664	2	its	-PRON-	PRP$
cord-006229-7yoilsho	1664	3	glucosyltransferase	glucosyltransferase	NN
cord-006229-7yoilsho	1664	4	activity	activity	NN
cord-006229-7yoilsho	1664	5	by	by	IN
cord-006229-7yoilsho	1664	6	which	which	WDT
cord-006229-7yoilsho	1664	7	the	the	DT
cord-006229-7yoilsho	1664	8	substrate	substrate	NN
cord-006229-7yoilsho	1664	9	proteins	protein	NNS
cord-006229-7yoilsho	1664	10	mainly	mainly	RB
cord-006229-7yoilsho	1664	11	of	of	IN
cord-006229-7yoilsho	1664	12	the	the	DT
cord-006229-7yoilsho	1664	13	family	family	NN
cord-006229-7yoilsho	1664	14	of	of	IN
cord-006229-7yoilsho	1664	15	Rho	Rho	NNP
cord-006229-7yoilsho	1664	16	GTPases	gtpase	NNS
cord-006229-7yoilsho	1664	17	are	be	VBP
cord-006229-7yoilsho	1664	18	inhibited	inhibit	VBN
cord-006229-7yoilsho	1664	19	,	,	,
cord-006229-7yoilsho	1664	20	TcdB	TcdB	NNP
cord-006229-7yoilsho	1664	21	has	have	VBZ
cord-006229-7yoilsho	1664	22	additional	additional	JJ
cord-006229-7yoilsho	1664	23	cytotoxic	cytotoxic	JJ
cord-006229-7yoilsho	1664	24	effects	effect	NNS
cord-006229-7yoilsho	1664	25	that	that	WDT
cord-006229-7yoilsho	1664	26	are	be	VBP
cord-006229-7yoilsho	1664	27	independent	independent	JJ
cord-006229-7yoilsho	1664	28	of	of	IN
cord-006229-7yoilsho	1664	29	Rho	Rho	NNP
cord-006229-7yoilsho	1664	30	glucosylation	glucosylation	NN
cord-006229-7yoilsho	1664	31	.	.	.
cord-006229-7yoilsho	1665	1	To	to	TO
cord-006229-7yoilsho	1665	2	investigate	investigate	VB
cord-006229-7yoilsho	1665	3	the	the	DT
cord-006229-7yoilsho	1665	4	mechanism	mechanism	NN
cord-006229-7yoilsho	1665	5	by	by	IN
cord-006229-7yoilsho	1665	6	which	which	WDT
cord-006229-7yoilsho	1665	7	TcdB	TcdB	NNP
cord-006229-7yoilsho	1665	8	induces	induce	VBZ
cord-006229-7yoilsho	1665	9	early	early	JJ
cord-006229-7yoilsho	1665	10	cell	cell	NN
cord-006229-7yoilsho	1665	11	death	death	NN
cord-006229-7yoilsho	1665	12	,	,	,
cord-006229-7yoilsho	1665	13	we	-PRON-	PRP
cord-006229-7yoilsho	1665	14	applied	apply	VBD
cord-006229-7yoilsho	1665	15	chimeras	chimera	NNS
cord-006229-7yoilsho	1665	16	of	of	IN
cord-006229-7yoilsho	1665	17	TcdB	TcdB	NNP
cord-006229-7yoilsho	1665	18	from	from	IN
cord-006229-7yoilsho	1665	19	different	different	JJ
cord-006229-7yoilsho	1665	20	toxinotypes	toxinotype	NNS
cord-006229-7yoilsho	1665	21	where	where	WRB
cord-006229-7yoilsho	1665	22	different	different	JJ
cord-006229-7yoilsho	1665	23	glucosyltransferase	glucosyltransferase	NN
cord-006229-7yoilsho	1665	24	domains	domain	NNS
cord-006229-7yoilsho	1665	25	were	be	VBD
cord-006229-7yoilsho	1665	26	combined	combine	VBN
cord-006229-7yoilsho	1665	27	with	with	IN
cord-006229-7yoilsho	1665	28	different	different	JJ
cord-006229-7yoilsho	1665	29	translocation	translocation	NN
cord-006229-7yoilsho	1665	30	domains	domain	NNS
cord-006229-7yoilsho	1665	31	.	.	.
cord-006229-7yoilsho	1666	1	To	to	IN
cord-006229-7yoilsho	1666	2	this	this	DT
cord-006229-7yoilsho	1666	3	end	end	NN
cord-006229-7yoilsho	1666	4	we	-PRON-	PRP
cord-006229-7yoilsho	1666	5	cloned	clone	VBD
cord-006229-7yoilsho	1666	6	TcdB	TcdB	NNP
cord-006229-7yoilsho	1666	7	from	from	IN
cord-006229-7yoilsho	1667	1	strain	strain	NN
cord-006229-7yoilsho	1667	2	VPI10463	VPI10463	NNP
cord-006229-7yoilsho	1667	3	(	(	-LRB-
cord-006229-7yoilsho	1667	4	historical	historical	JJ
cord-006229-7yoilsho	1667	5	strain	strain	NN
cord-006229-7yoilsho	1667	6	)	)	-RRB-
cord-006229-7yoilsho	1667	7	,	,	,
cord-006229-7yoilsho	1667	8	strain	strain	VB
cord-006229-7yoilsho	1667	9	1479	1479	CD
cord-006229-7yoilsho	1668	1	(	(	-LRB-
cord-006229-7yoilsho	1668	2	Serotype	Serotype	NNP
cord-006229-7yoilsho	1668	3	F	F	NNP
cord-006229-7yoilsho	1668	4	,	,	,
cord-006229-7yoilsho	1668	5	variant	variant	JJ
cord-006229-7yoilsho	1668	6	TcdBF	TcdBF	NNP
cord-006229-7yoilsho	1668	7	)	)	-RRB-
cord-006229-7yoilsho	1668	8	,	,	,
cord-006229-7yoilsho	1668	9	strain	strain	VB
cord-006229-7yoilsho	1668	10	R20291	R20291	NNP
cord-006229-7yoilsho	1669	1	(	(	-LRB-
cord-006229-7yoilsho	1669	2	hypervirulent	hypervirulent	NNP
cord-006229-7yoilsho	1669	3	strain	strain	NN
cord-006229-7yoilsho	1669	4	,	,	,
cord-006229-7yoilsho	1669	5	ribotype	ribotype	NNP
cord-006229-7yoilsho	1669	6	O27	O27	NNP
cord-006229-7yoilsho	1669	7	)	)	-RRB-
cord-006229-7yoilsho	1669	8	,	,	,
cord-006229-7yoilsho	1669	9	and	and	CC
cord-006229-7yoilsho	1669	10	strain	strain	VB
cord-006229-7yoilsho	1669	11	R9385	R9385	NNP
cord-006229-7yoilsho	1670	1	(	(	-LRB-
cord-006229-7yoilsho	1670	2	hypervirulent	hypervirulent	NN
cord-006229-7yoilsho	1670	3	strain	strain	NN
cord-006229-7yoilsho	1670	4	with	with	IN
cord-006229-7yoilsho	1670	5	TcdBF	TcdBF	NNP
cord-006229-7yoilsho	1670	6	characteristics	characteristic	NNS
cord-006229-7yoilsho	1670	7	)	)	-RRB-
cord-006229-7yoilsho	1670	8	.	.	.
cord-006229-7yoilsho	1671	1	We	-PRON-	PRP
cord-006229-7yoilsho	1671	2	were	be	VBD
cord-006229-7yoilsho	1671	3	able	able	JJ
cord-006229-7yoilsho	1671	4	to	to	TO
cord-006229-7yoilsho	1671	5	investigate	investigate	VB
cord-006229-7yoilsho	1671	6	the	the	DT
cord-006229-7yoilsho	1671	7	impact	impact	NN
cord-006229-7yoilsho	1671	8	of	of	IN
cord-006229-7yoilsho	1671	9	the	the	DT
cord-006229-7yoilsho	1671	10	glucosyltransferase	glucosyltransferase	NNP
cord-006229-7yoilsho	1671	11	domains	domain	NNS
cord-006229-7yoilsho	1671	12	with	with	IN
cord-006229-7yoilsho	1671	13	different	different	JJ
cord-006229-7yoilsho	1671	14	substrate	substrate	NN
cord-006229-7yoilsho	1671	15	specificity	specificity	NN
cord-006229-7yoilsho	1671	16	when	when	WRB
cord-006229-7yoilsho	1671	17	translocated	translocate	VBN
cord-006229-7yoilsho	1671	18	into	into	IN
cord-006229-7yoilsho	1671	19	the	the	DT
cord-006229-7yoilsho	1671	20	host	host	NN
cord-006229-7yoilsho	1671	21	cell	cell	NN
cord-006229-7yoilsho	1671	22	by	by	IN
cord-006229-7yoilsho	1671	23	identical	identical	JJ
cord-006229-7yoilsho	1671	24	translocation	translocation	NN
cord-006229-7yoilsho	1671	25	domains	domain	NNS
cord-006229-7yoilsho	1671	26	.	.	.
cord-006229-7yoilsho	1672	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	1672	2	,	,	,
cord-006229-7yoilsho	1672	3	we	-PRON-	PRP
cord-006229-7yoilsho	1672	4	tested	test	VBD
cord-006229-7yoilsho	1672	5	different	different	JJ
cord-006229-7yoilsho	1672	6	translocation	translocation	NN
cord-006229-7yoilsho	1672	7	domains	domain	NNS
cord-006229-7yoilsho	1672	8	to	to	TO
cord-006229-7yoilsho	1672	9	deliver	deliver	VB
cord-006229-7yoilsho	1672	10	the	the	DT
cord-006229-7yoilsho	1672	11	same	same	JJ
cord-006229-7yoilsho	1672	12	glucosyltransferase	glucosyltransferase	NN
cord-006229-7yoilsho	1672	13	domain	domain	NN
cord-006229-7yoilsho	1672	14	into	into	IN
cord-006229-7yoilsho	1672	15	host	host	NN
cord-006229-7yoilsho	1672	16	cells	cell	NNS
cord-006229-7yoilsho	1672	17	.	.	.
cord-006229-7yoilsho	1673	1	We	-PRON-	PRP
cord-006229-7yoilsho	1673	2	found	find	VBD
cord-006229-7yoilsho	1673	3	that	that	IN
cord-006229-7yoilsho	1673	4	the	the	DT
cord-006229-7yoilsho	1673	5	glucosyltransferase	glucosyltransferase	NNP
cord-006229-7yoilsho	1673	6	domain	domain	NN
cord-006229-7yoilsho	1673	7	of	of	IN
cord-006229-7yoilsho	1673	8	TcdBF	TcdBF	NNP
cord-006229-7yoilsho	1673	9	(	(	-LRB-
cord-006229-7yoilsho	1673	10	strain	strain	NN
cord-006229-7yoilsho	1673	11	1470	1470	CD
cord-006229-7yoilsho	1673	12	)	)	-RRB-
cord-006229-7yoilsho	1673	13	is	be	VBZ
cord-006229-7yoilsho	1673	14	less	less	RBR
cord-006229-7yoilsho	1673	15	cytotoxic	cytotoxic	JJ
cord-006229-7yoilsho	1673	16	with	with	IN
cord-006229-7yoilsho	1673	17	respect	respect	NN
cord-006229-7yoilsho	1673	18	to	to	IN
cord-006229-7yoilsho	1673	19	early	early	JJ
cord-006229-7yoilsho	1673	20	cell	cell	NN
cord-006229-7yoilsho	1673	21	death	death	NN
cord-006229-7yoilsho	1673	22	mediated	mediate	VBN
cord-006229-7yoilsho	1673	23	by	by	IN
cord-006229-7yoilsho	1673	24	reactive	reactive	JJ
cord-006229-7yoilsho	1673	25	oxygen	oxygen	NN
cord-006229-7yoilsho	1673	26	species	specie	NNS
cord-006229-7yoilsho	1673	27	than	than	IN
cord-006229-7yoilsho	1673	28	that	that	DT
cord-006229-7yoilsho	1673	29	from	from	IN
cord-006229-7yoilsho	1673	30	reference	reference	NN
cord-006229-7yoilsho	1673	31	strain	strain	NN
cord-006229-7yoilsho	1673	32	VPI10463	vpi10463	NN
cord-006229-7yoilsho	1673	33	.	.	.
cord-006229-7yoilsho	1674	1	In	in	IN
cord-006229-7yoilsho	1674	2	addition	addition	NN
cord-006229-7yoilsho	1674	3	,	,	,
cord-006229-7yoilsho	1674	4	the	the	DT
cord-006229-7yoilsho	1674	5	translocation	translocation	NN
cord-006229-7yoilsho	1674	6	domain	domain	NN
cord-006229-7yoilsho	1674	7	also	also	RB
cord-006229-7yoilsho	1674	8	showed	show	VBD
cord-006229-7yoilsho	1674	9	significant	significant	JJ
cord-006229-7yoilsho	1674	10	impact	impact	NN
cord-006229-7yoilsho	1674	11	on	on	IN
cord-006229-7yoilsho	1674	12	cytotoxicity	cytotoxicity	NN
cord-006229-7yoilsho	1674	13	,	,	,
cord-006229-7yoilsho	1674	14	probably	probably	RB
cord-006229-7yoilsho	1674	15	by	by	IN
cord-006229-7yoilsho	1674	16	faster	fast	JJR
cord-006229-7yoilsho	1674	17	intracellular	intracellular	JJ
cord-006229-7yoilsho	1674	18	delivery	delivery	NN
cord-006229-7yoilsho	1674	19	of	of	IN
cord-006229-7yoilsho	1674	20	the	the	DT
cord-006229-7yoilsho	1674	21	GTD	GTD	NNP
cord-006229-7yoilsho	1674	22	.	.	.
cord-006229-7yoilsho	1675	1	By	by	IN
cord-006229-7yoilsho	1675	2	using	use	VBG
cord-006229-7yoilsho	1675	3	glucosyltransferase	glucosyltransferase	NN
cord-006229-7yoilsho	1675	4	deficient	deficient	JJ
cord-006229-7yoilsho	1675	5	mutants	mutant	NNS
cord-006229-7yoilsho	1675	6	where	where	WRB
cord-006229-7yoilsho	1675	7	the	the	DT
cord-006229-7yoilsho	1675	8	highly	highly	RB
cord-006229-7yoilsho	1675	9	conserved	conserve	VBN
cord-006229-7yoilsho	1675	10	DXD	DXD	NNP
cord-006229-7yoilsho	1675	11	-	-	HYPH
cord-006229-7yoilsho	1675	12	motif	motif	NN
cord-006229-7yoilsho	1675	13	was	be	VBD
cord-006229-7yoilsho	1675	14	changed	change	VBN
cord-006229-7yoilsho	1675	15	to	to	IN
cord-006229-7yoilsho	1675	16	NXN	NXN	NNP
cord-006229-7yoilsho	1675	17	,	,	,
cord-006229-7yoilsho	1675	18	we	-PRON-	PRP
cord-006229-7yoilsho	1675	19	were	be	VBD
cord-006229-7yoilsho	1675	20	able	able	JJ
cord-006229-7yoilsho	1675	21	to	to	TO
cord-006229-7yoilsho	1675	22	show	show	VB
cord-006229-7yoilsho	1675	23	that	that	IN
cord-006229-7yoilsho	1675	24	glucosylation	glucosylation	NN
cord-006229-7yoilsho	1675	25	of	of	IN
cord-006229-7yoilsho	1675	26	Rho	Rho	NNP
cord-006229-7yoilsho	1675	27	GTPases	gtpase	NNS
cord-006229-7yoilsho	1675	28	counteracts	counteract	VBZ
cord-006229-7yoilsho	1675	29	the	the	DT
cord-006229-7yoilsho	1675	30	cytotoxic	cytotoxic	JJ
cord-006229-7yoilsho	1675	31	effect	effect	NN
cord-006229-7yoilsho	1675	32	,	,	,
cord-006229-7yoilsho	1675	33	since	since	IN
cord-006229-7yoilsho	1675	34	the	the	DT
cord-006229-7yoilsho	1675	35	mutants	mutant	NNS
cord-006229-7yoilsho	1675	36	were	be	VBD
cord-006229-7yoilsho	1675	37	more	more	RBR
cord-006229-7yoilsho	1675	38	cytotoxic	cytotoxic	JJ
cord-006229-7yoilsho	1675	39	than	than	IN
cord-006229-7yoilsho	1675	40	wildtype	wildtype	JJ
cord-006229-7yoilsho	1675	41	toxins	toxin	NNS
cord-006229-7yoilsho	1675	42	.	.	.
cord-006229-7yoilsho	1676	1	In	in	IN
cord-006229-7yoilsho	1676	2	conclusion	conclusion	NN
cord-006229-7yoilsho	1676	3	,	,	,
cord-006229-7yoilsho	1676	4	the	the	DT
cord-006229-7yoilsho	1676	5	cytotoxicity	cytotoxicity	NN
cord-006229-7yoilsho	1676	6	of	of	IN
cord-006229-7yoilsho	1676	7	TcdB	TcdB	NNP
cord-006229-7yoilsho	1676	8	mainly	mainly	RB
cord-006229-7yoilsho	1676	9	depends	depend	VBZ
cord-006229-7yoilsho	1676	10	on	on	IN
cord-006229-7yoilsho	1676	11	the	the	DT
cord-006229-7yoilsho	1676	12	translocation	translocation	NN
cord-006229-7yoilsho	1676	13	efficiency	efficiency	NN
cord-006229-7yoilsho	1676	14	into	into	IN
cord-006229-7yoilsho	1676	15	the	the	DT
cord-006229-7yoilsho	1676	16	host	host	NN
cord-006229-7yoilsho	1676	17	cell	cell	NN
cord-006229-7yoilsho	1676	18	and	and	CC
cord-006229-7yoilsho	1676	19	on	on	IN
cord-006229-7yoilsho	1676	20	the	the	DT
cord-006229-7yoilsho	1676	21	kinetic	kinetic	NN
cord-006229-7yoilsho	1676	22	of	of	IN
cord-006229-7yoilsho	1676	23	glucosylation	glucosylation	NN
cord-006229-7yoilsho	1676	24	of	of	IN
cord-006229-7yoilsho	1676	25	their	-PRON-	PRP$
cord-006229-7yoilsho	1676	26	substrate	substrate	NN
cord-006229-7yoilsho	1676	27	GTPases	gtpase	NNS
cord-006229-7yoilsho	1676	28	.	.	.
cord-006229-7yoilsho	1677	1	Thus	thus	RB
cord-006229-7yoilsho	1677	2	,	,	,
cord-006229-7yoilsho	1677	3	sensitivity	sensitivity	NN
cord-006229-7yoilsho	1677	4	of	of	IN
cord-006229-7yoilsho	1677	5	target	target	NN
cord-006229-7yoilsho	1677	6	cells	cell	NNS
cord-006229-7yoilsho	1677	7	towards	towards	IN
cord-006229-7yoilsho	1677	8	cytotoxic	cytotoxic	JJ
cord-006229-7yoilsho	1677	9	effect	effect	NN
cord-006229-7yoilsho	1677	10	also	also	RB
cord-006229-7yoilsho	1677	11	depends	depend	VBZ
cord-006229-7yoilsho	1677	12	on	on	IN
cord-006229-7yoilsho	1677	13	receptor	receptor	NN
cord-006229-7yoilsho	1677	14	abundancy	abundancy	NN
cord-006229-7yoilsho	1677	15	and	and	CC
cord-006229-7yoilsho	1677	16	intracellular	intracellular	JJ
cord-006229-7yoilsho	1677	17	status	status	NN
cord-006229-7yoilsho	1677	18	of	of	IN
cord-006229-7yoilsho	1677	19	Rho	rho	NN
cord-006229-7yoilsho	1677	20	GTPases	gtpase	NNS
cord-006229-7yoilsho	1677	21	,	,	,
cord-006229-7yoilsho	1677	22	whereas	whereas	IN
cord-006229-7yoilsho	1677	23	the	the	DT
cord-006229-7yoilsho	1677	24	cytopathic	cytopathic	JJ
cord-006229-7yoilsho	1677	25	effect	effect	NN
cord-006229-7yoilsho	1677	26	,	,	,
cord-006229-7yoilsho	1677	27	i.e.	i.e.	FW
cord-006229-7yoilsho	1677	28	cell	cell	NN
cord-006229-7yoilsho	1677	29	rounding	rounding	NN
cord-006229-7yoilsho	1677	30	,	,	,
cord-006229-7yoilsho	1677	31	is	be	VBZ
cord-006229-7yoilsho	1677	32	predominatly	predominatly	RB
cord-006229-7yoilsho	1677	33	determined	determine	VBN
cord-006229-7yoilsho	1677	34	by	by	IN
cord-006229-7yoilsho	1677	35	the	the	DT
cord-006229-7yoilsho	1677	36	substrate	substrate	NN
cord-006229-7yoilsho	1677	37	specificity	specificity	NN
cord-006229-7yoilsho	1677	38	.	.	.
cord-006229-7yoilsho	1678	1	Introduction	introduction	NN
cord-006229-7yoilsho	1678	2	:	:	:
cord-006229-7yoilsho	1678	3	p63RhoGEF	p63rhogef	NN
cord-006229-7yoilsho	1678	4	activates	activate	VBZ
cord-006229-7yoilsho	1678	5	the	the	DT
cord-006229-7yoilsho	1678	6	G	g	NN
cord-006229-7yoilsho	1678	7	protein	protein	NN
cord-006229-7yoilsho	1678	8	-	-	HYPH
cord-006229-7yoilsho	1678	9	coupled	couple	VBN
cord-006229-7yoilsho	1678	10	receptor	receptor	NN
cord-006229-7yoilsho	1678	11	(	(	-LRB-
cord-006229-7yoilsho	1678	12	GPCR)-mediated	gpcr)-mediate	VBN
cord-006229-7yoilsho	1678	13	induction	induction	NN
cord-006229-7yoilsho	1678	14	of	of	IN
cord-006229-7yoilsho	1678	15	RhoA	RhoA	NNP
cord-006229-7yoilsho	1678	16	in	in	IN
cord-006229-7yoilsho	1678	17	different	different	JJ
cord-006229-7yoilsho	1678	18	cells	cell	NNS
cord-006229-7yoilsho	1678	19	.	.	.
cord-006229-7yoilsho	1679	1	However	however	RB
cord-006229-7yoilsho	1679	2	,	,	,
cord-006229-7yoilsho	1679	3	its	-PRON-	PRP$
cord-006229-7yoilsho	1679	4	role	role	NN
cord-006229-7yoilsho	1679	5	in	in	IN
cord-006229-7yoilsho	1679	6	cardiac	cardiac	JJ
cord-006229-7yoilsho	1679	7	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	1679	8	(	(	-LRB-
cord-006229-7yoilsho	1679	9	CF	CF	NNP
cord-006229-7yoilsho	1679	10	)	)	-RRB-
cord-006229-7yoilsho	1679	11	is	be	VBZ
cord-006229-7yoilsho	1679	12	not	not	RB
cord-006229-7yoilsho	1679	13	defined	define	VBN
cord-006229-7yoilsho	1679	14	yet	yet	RB
cord-006229-7yoilsho	1679	15	.	.	.
cord-006229-7yoilsho	1680	1	Thus	thus	RB
cord-006229-7yoilsho	1680	2	we	-PRON-	PRP
cord-006229-7yoilsho	1680	3	studied	study	VBD
cord-006229-7yoilsho	1680	4	its	-PRON-	PRP$
cord-006229-7yoilsho	1680	5	localization	localization	NN
cord-006229-7yoilsho	1680	6	and	and	CC
cord-006229-7yoilsho	1680	7	function	function	NN
cord-006229-7yoilsho	1680	8	in	in	IN
cord-006229-7yoilsho	1680	9	CF	CF	NNP
cord-006229-7yoilsho	1680	10	in	in	IN
cord-006229-7yoilsho	1680	11	2D	2D	NNP
cord-006229-7yoilsho	1680	12	and	and	CC
cord-006229-7yoilsho	1680	13	3D	3d	JJ
cord-006229-7yoilsho	1680	14	culture	culture	NN
cord-006229-7yoilsho	1680	15	experiments	experiment	NNS
cord-006229-7yoilsho	1680	16	.	.	.
cord-006229-7yoilsho	1681	1	Methods	method	NNS
cord-006229-7yoilsho	1681	2	:	:	:
cord-006229-7yoilsho	1681	3	Neonatal	neonatal	JJ
cord-006229-7yoilsho	1681	4	rat	rat	NN
cord-006229-7yoilsho	1681	5	cardiac	cardiac	NN
cord-006229-7yoilsho	1681	6	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	1681	7	(	(	-LRB-
cord-006229-7yoilsho	1681	8	NRCF	NRCF	NNP
cord-006229-7yoilsho	1681	9	)	)	-RRB-
cord-006229-7yoilsho	1681	10	and	and	CC
cord-006229-7yoilsho	1681	11	adult	adult	NN
cord-006229-7yoilsho	1681	12	ventricular	ventricular	JJ
cord-006229-7yoilsho	1681	13	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	1681	14	(	(	-LRB-
cord-006229-7yoilsho	1681	15	AMCF	AMCF	NNP
cord-006229-7yoilsho	1681	16	)	)	-RRB-
cord-006229-7yoilsho	1681	17	from	from	IN
cord-006229-7yoilsho	1681	18	wild	wild	JJ
cord-006229-7yoilsho	1681	19	type	type	NN
cord-006229-7yoilsho	1681	20	mice	mouse	NNS
cord-006229-7yoilsho	1681	21	and	and	CC
cord-006229-7yoilsho	1681	22	p63RhoGEF	p63rhogef	CD
cord-006229-7yoilsho	1681	23	-	-	HYPH
cord-006229-7yoilsho	1681	24	knockout	knockout	NN
cord-006229-7yoilsho	1681	25	mice	mouse	NNS
cord-006229-7yoilsho	1681	26	were	be	VBD
cord-006229-7yoilsho	1681	27	adenovirally	adenovirally	RB
cord-006229-7yoilsho	1681	28	transduced	transduce	VBN
cord-006229-7yoilsho	1681	29	for	for	IN
cord-006229-7yoilsho	1681	30	48	48	CD
cord-006229-7yoilsho	1681	31	to	to	TO
cord-006229-7yoilsho	1681	32	72	72	CD
cord-006229-7yoilsho	1681	33	h	h	NN
cord-006229-7yoilsho	1681	34	with	with	IN
cord-006229-7yoilsho	1681	35	recombinant	recombinant	JJ
cord-006229-7yoilsho	1681	36	adenoviruses	adenovirus	NNS
cord-006229-7yoilsho	1681	37	or	or	CC
cord-006229-7yoilsho	1681	38	directly	directly	RB
cord-006229-7yoilsho	1681	39	used	use	VBN
cord-006229-7yoilsho	1681	40	.	.	.
cord-006229-7yoilsho	1682	1	For	for	IN
cord-006229-7yoilsho	1682	2	2D	2D	NNP
cord-006229-7yoilsho	1682	3	studies	study	NNS
cord-006229-7yoilsho	1682	4	the	the	DT
cord-006229-7yoilsho	1682	5	cells	cell	NNS
cord-006229-7yoilsho	1682	6	were	be	VBD
cord-006229-7yoilsho	1682	7	treated	treat	VBN
cord-006229-7yoilsho	1682	8	with	with	IN
cord-006229-7yoilsho	1682	9	angiotensin	angiotensin	NN
cord-006229-7yoilsho	1682	10	II	II	NNP
cord-006229-7yoilsho	1682	11	(	(	-LRB-
cord-006229-7yoilsho	1682	12	Ang	Ang	NNP
cord-006229-7yoilsho	1682	13	II	II	NNP
cord-006229-7yoilsho	1682	14	)	)	-RRB-
cord-006229-7yoilsho	1682	15	.	.	.
cord-006229-7yoilsho	1683	1	The	the	DT
cord-006229-7yoilsho	1683	2	location	location	NN
cord-006229-7yoilsho	1683	3	of	of	IN
cord-006229-7yoilsho	1683	4	the	the	DT
cord-006229-7yoilsho	1683	5	involved	involve	VBN
cord-006229-7yoilsho	1683	6	signaling	signal	VBG
cord-006229-7yoilsho	1683	7	components	component	NNS
cord-006229-7yoilsho	1683	8	,	,	,
cord-006229-7yoilsho	1683	9	RhoA	RhoA	NNP
cord-006229-7yoilsho	1683	10	activation	activation	NN
cord-006229-7yoilsho	1683	11	and	and	CC
cord-006229-7yoilsho	1683	12	down	down	IN
cord-006229-7yoilsho	1683	13	-	-	HYPH
cord-006229-7yoilsho	1683	14	stream	stream	NN
cord-006229-7yoilsho	1683	15	effects	effect	NNS
cord-006229-7yoilsho	1683	16	were	be	VBD
cord-006229-7yoilsho	1683	17	studied	study	VBN
cord-006229-7yoilsho	1683	18	by	by	IN
cord-006229-7yoilsho	1683	19	confocal	confocal	JJ
cord-006229-7yoilsho	1683	20	microscopy	microscopy	NNS
cord-006229-7yoilsho	1683	21	and	and	CC
cord-006229-7yoilsho	1683	22	biochemical	biochemical	JJ
cord-006229-7yoilsho	1683	23	analyses	analysis	NNS
cord-006229-7yoilsho	1683	24	.	.	.
cord-006229-7yoilsho	1684	1	In	in	IN
cord-006229-7yoilsho	1684	2	addition	addition	NN
cord-006229-7yoilsho	1684	3	,	,	,
cord-006229-7yoilsho	1684	4	CF	CF	NNP
cord-006229-7yoilsho	1684	5	were	be	VBD
cord-006229-7yoilsho	1684	6	used	use	VBN
cord-006229-7yoilsho	1684	7	to	to	TO
cord-006229-7yoilsho	1684	8	prepare	prepare	VB
cord-006229-7yoilsho	1684	9	CF	cf	NN
cord-006229-7yoilsho	1684	10	-	-	HYPH
cord-006229-7yoilsho	1684	11	containing	contain	VBG
cord-006229-7yoilsho	1684	12	engineered	engineer	VBN
cord-006229-7yoilsho	1684	13	connective	connective	NN
cord-006229-7yoilsho	1684	14	(	(	-LRB-
cord-006229-7yoilsho	1684	15	ECT	ECT	NNP
cord-006229-7yoilsho	1684	16	)	)	-RRB-
cord-006229-7yoilsho	1684	17	or	or	CC
cord-006229-7yoilsho	1684	18	muscle	muscle	NN
cord-006229-7yoilsho	1684	19	(	(	-LRB-
cord-006229-7yoilsho	1684	20	EHM	ehm	UH
cord-006229-7yoilsho	1684	21	)	)	-RRB-
cord-006229-7yoilsho	1684	22	tissues	tissue	NNS
cord-006229-7yoilsho	1684	23	.	.	.
cord-006229-7yoilsho	1685	1	Results	result	NNS
cord-006229-7yoilsho	1685	2	:	:	:
cord-006229-7yoilsho	1685	3	We	-PRON-	PRP
cord-006229-7yoilsho	1685	4	could	could	MD
cord-006229-7yoilsho	1685	5	show	show	VB
cord-006229-7yoilsho	1685	6	that	that	IN
cord-006229-7yoilsho	1685	7	p63RhoGEF	p63rhogef	PRP
cord-006229-7yoilsho	1685	8	locates	locate	VBZ
cord-006229-7yoilsho	1685	9	at	at	IN
cord-006229-7yoilsho	1685	10	the	the	DT
cord-006229-7yoilsho	1685	11	plasma	plasma	NN
cord-006229-7yoilsho	1685	12	membrane	membrane	NN
cord-006229-7yoilsho	1685	13	,	,	,
cord-006229-7yoilsho	1685	14	adjacent	adjacent	JJ
cord-006229-7yoilsho	1685	15	to	to	IN
cord-006229-7yoilsho	1685	16	the	the	DT
cord-006229-7yoilsho	1685	17	Golgi	Golgi	NNP
cord-006229-7yoilsho	1685	18	apparatus	apparatus	NN
cord-006229-7yoilsho	1685	19	and	and	CC
cord-006229-7yoilsho	1685	20	at	at	IN
cord-006229-7yoilsho	1685	21	the	the	DT
cord-006229-7yoilsho	1685	22	base	base	NN
cord-006229-7yoilsho	1685	23	of	of	IN
cord-006229-7yoilsho	1685	24	primary	primary	JJ
cord-006229-7yoilsho	1685	25	cilia	cilium	NNS
cord-006229-7yoilsho	1685	26	.	.	.
cord-006229-7yoilsho	1686	1	In	in	IN
cord-006229-7yoilsho	1686	2	accordance	accordance	NN
cord-006229-7yoilsho	1686	3	,	,	,
cord-006229-7yoilsho	1686	4	p63RhoGEF	p63rhogef	NN
cord-006229-7yoilsho	1686	5	regulates	regulate	VBZ
cord-006229-7yoilsho	1686	6	in	in	IN
cord-006229-7yoilsho	1686	7	response	response	NN
cord-006229-7yoilsho	1686	8	to	to	IN
cord-006229-7yoilsho	1686	9	Ang	Ang	NNP
cord-006229-7yoilsho	1686	10	II	II	NNP
cord-006229-7yoilsho	1686	11	the	the	DT
cord-006229-7yoilsho	1686	12	expression	expression	NN
cord-006229-7yoilsho	1686	13	and	and	CC
cord-006229-7yoilsho	1686	14	secretion	secretion	NN
cord-006229-7yoilsho	1686	15	of	of	IN
cord-006229-7yoilsho	1686	16	the	the	DT
cord-006229-7yoilsho	1686	17	connective	connective	JJ
cord-006229-7yoilsho	1686	18	tissue	tissue	NN
cord-006229-7yoilsho	1686	19	growth	growth	NN
cord-006229-7yoilsho	1686	20	factor	factor	NN
cord-006229-7yoilsho	1686	21	(	(	-LRB-
cord-006229-7yoilsho	1686	22	CTGF	CTGF	NNP
cord-006229-7yoilsho	1686	23	)	)	-RRB-
cord-006229-7yoilsho	1686	24	in	in	IN
cord-006229-7yoilsho	1686	25	NRCF	NRCF	NNP
cord-006229-7yoilsho	1686	26	involving	involve	VBG
cord-006229-7yoilsho	1686	27	the	the	DT
cord-006229-7yoilsho	1686	28	serum	serum	NN
cord-006229-7yoilsho	1686	29	response	response	NN
cord-006229-7yoilsho	1686	30	factor	factor	NN
cord-006229-7yoilsho	1686	31	.	.	.
cord-006229-7yoilsho	1687	1	In	in	IN
cord-006229-7yoilsho	1687	2	ECT	ECT	NNP
cord-006229-7yoilsho	1687	3	,	,	,
cord-006229-7yoilsho	1687	4	p63RhoGEF	p63rhogef	NN
cord-006229-7yoilsho	1687	5	increases	increase	VBZ
cord-006229-7yoilsho	1687	6	the	the	DT
cord-006229-7yoilsho	1687	7	stiffness	stiffness	NN
cord-006229-7yoilsho	1687	8	of	of	IN
cord-006229-7yoilsho	1687	9	these	these	DT
cord-006229-7yoilsho	1687	10	tissues	tissue	NNS
cord-006229-7yoilsho	1687	11	and	and	CC
cord-006229-7yoilsho	1687	12	in	in	IN
cord-006229-7yoilsho	1687	13	EHM	EHM	NNP
cord-006229-7yoilsho	1687	14	containing	contain	VBG
cord-006229-7yoilsho	1687	15	CF	cf	NN
cord-006229-7yoilsho	1687	16	expressing	express	VBG
cord-006229-7yoilsho	1687	17	gain	gain	NN
cord-006229-7yoilsho	1687	18	-	-	HYPH
cord-006229-7yoilsho	1687	19	and	and	CC
cord-006229-7yoilsho	1687	20	-	-	HYPH
cord-006229-7yoilsho	1687	21	loss	loss	NN
cord-006229-7yoilsho	1687	22	-	-	HYPH
cord-006229-7yoilsho	1687	23	of	of	IN
cord-006229-7yoilsho	1687	24	-	-	HYPH
cord-006229-7yoilsho	1687	25	function	function	NN
cord-006229-7yoilsho	1687	26	p63RhoGEF	p63rhogef	NN
cord-006229-7yoilsho	1687	27	variants	variant	NNS
cord-006229-7yoilsho	1687	28	it	-PRON-	PRP
cord-006229-7yoilsho	1687	29	influences	influence	VBZ
cord-006229-7yoilsho	1687	30	the	the	DT
cord-006229-7yoilsho	1687	31	contractility	contractility	NN
cord-006229-7yoilsho	1687	32	.	.	.
cord-006229-7yoilsho	1688	1	Interestingly	interestingly	RB
cord-006229-7yoilsho	1688	2	,	,	,
cord-006229-7yoilsho	1688	3	the	the	DT
cord-006229-7yoilsho	1688	4	increase	increase	NN
cord-006229-7yoilsho	1688	5	in	in	IN
cord-006229-7yoilsho	1688	6	ECT	ECT	NNP
cord-006229-7yoilsho	1688	7	stiffness	stiffness	NN
cord-006229-7yoilsho	1688	8	was	be	VBD
cord-006229-7yoilsho	1688	9	independent	independent	JJ
cord-006229-7yoilsho	1688	10	of	of	IN
cord-006229-7yoilsho	1688	11	p63RhoGEF	p63RhoGEF	NNP
cord-006229-7yoilsho	1688	12	's	's	POS
cord-006229-7yoilsho	1688	13	regulatory	regulatory	JJ
cord-006229-7yoilsho	1688	14	function	function	NN
cord-006229-7yoilsho	1688	15	of	of	IN
cord-006229-7yoilsho	1688	16	CTGF	CTGF	NNP
cord-006229-7yoilsho	1688	17	,	,	,
cord-006229-7yoilsho	1688	18	as	as	IN
cord-006229-7yoilsho	1688	19	overexpression	overexpression	NN
cord-006229-7yoilsho	1688	20	of	of	IN
cord-006229-7yoilsho	1688	21	CTGF	CTGF	NNP
cord-006229-7yoilsho	1688	22	in	in	IN
cord-006229-7yoilsho	1688	23	CF	CF	NNP
cord-006229-7yoilsho	1688	24	had	have	VBD
cord-006229-7yoilsho	1688	25	no	no	DT
cord-006229-7yoilsho	1688	26	impact	impact	NN
cord-006229-7yoilsho	1688	27	on	on	IN
cord-006229-7yoilsho	1688	28	ECT	ECT	NNP
cord-006229-7yoilsho	1688	29	properties	property	NNS
cord-006229-7yoilsho	1688	30	arguing	argue	VBG
cord-006229-7yoilsho	1688	31	for	for	IN
cord-006229-7yoilsho	1688	32	a	a	DT
cord-006229-7yoilsho	1688	33	more	more	RBR
cord-006229-7yoilsho	1688	34	general	general	JJ
cord-006229-7yoilsho	1688	35	role	role	NN
cord-006229-7yoilsho	1688	36	of	of	IN
cord-006229-7yoilsho	1688	37	p63RhoGEF	p63rhogef	CD
cord-006229-7yoilsho	1688	38	in	in	IN
cord-006229-7yoilsho	1688	39	auto	auto	NN
cord-006229-7yoilsho	1688	40	-	-	HYPH
cord-006229-7yoilsho	1688	41	and	and	CC
cord-006229-7yoilsho	1688	42	paracrine	paracrine	JJ
cord-006229-7yoilsho	1688	43	signaling	signaling	NN
cord-006229-7yoilsho	1688	44	.	.	.
cord-006229-7yoilsho	1689	1	Moreover	moreover	RB
cord-006229-7yoilsho	1689	2	,	,	,
cord-006229-7yoilsho	1689	3	our	-PRON-	PRP$
cord-006229-7yoilsho	1689	4	data	datum	NNS
cord-006229-7yoilsho	1689	5	on	on	IN
cord-006229-7yoilsho	1689	6	AMCF	AMCF	NNP
cord-006229-7yoilsho	1689	7	with	with	IN
cord-006229-7yoilsho	1689	8	a	a	DT
cord-006229-7yoilsho	1689	9	genetic	genetic	JJ
cord-006229-7yoilsho	1689	10	deletion	deletion	NN
cord-006229-7yoilsho	1689	11	of	of	IN
cord-006229-7yoilsho	1689	12	p63RhoGEF	p63rhogef	NN
cord-006229-7yoilsho	1689	13	implies	imply	VBZ
cord-006229-7yoilsho	1689	14	that	that	IN
cord-006229-7yoilsho	1689	15	p63RhoGEF	p63rhogef	NN
cord-006229-7yoilsho	1689	16	is	be	VBZ
cord-006229-7yoilsho	1689	17	not	not	RB
cord-006229-7yoilsho	1689	18	only	only	RB
cord-006229-7yoilsho	1689	19	a	a	DT
cord-006229-7yoilsho	1689	20	transducer	transducer	NN
cord-006229-7yoilsho	1689	21	of	of	IN
cord-006229-7yoilsho	1689	22	GPCR	GPCR	NNP
cord-006229-7yoilsho	1689	23	-	-	HYPH
cord-006229-7yoilsho	1689	24	dependent	dependent	JJ
cord-006229-7yoilsho	1689	25	RhoA	RhoA	NNP
cord-006229-7yoilsho	1689	26	activation	activation	NN
cord-006229-7yoilsho	1689	27	as	as	IN
cord-006229-7yoilsho	1689	28	its	-PRON-	PRP$
cord-006229-7yoilsho	1689	29	loss	loss	NN
cord-006229-7yoilsho	1689	30	led	lead	VBD
cord-006229-7yoilsho	1689	31	to	to	IN
cord-006229-7yoilsho	1689	32	an	an	DT
cord-006229-7yoilsho	1689	33	increase	increase	NN
cord-006229-7yoilsho	1689	34	in	in	IN
cord-006229-7yoilsho	1689	35	RhoA	RhoA	NNP
cord-006229-7yoilsho	1689	36	expression	expression	NN
cord-006229-7yoilsho	1689	37	accompanied	accompany	VBN
cord-006229-7yoilsho	1689	38	by	by	IN
cord-006229-7yoilsho	1689	39	an	an	DT
cord-006229-7yoilsho	1689	40	increase	increase	NN
cord-006229-7yoilsho	1689	41	in	in	IN
cord-006229-7yoilsho	1689	42	RhoA	RhoA	NNP
cord-006229-7yoilsho	1689	43	-	-	HYPH
cord-006229-7yoilsho	1689	44	dependent	dependent	JJ
cord-006229-7yoilsho	1689	45	gene	gene	NN
cord-006229-7yoilsho	1689	46	expression	expression	NN
cord-006229-7yoilsho	1689	47	suggesting	suggest	VBG
cord-006229-7yoilsho	1689	48	a	a	DT
cord-006229-7yoilsho	1689	49	role	role	NN
cord-006229-7yoilsho	1689	50	of	of	IN
cord-006229-7yoilsho	1689	51	p63RhoGEF	p63rhogef	CD
cord-006229-7yoilsho	1689	52	in	in	IN
cord-006229-7yoilsho	1689	53	the	the	DT
cord-006229-7yoilsho	1689	54	feedback	feedback	NN
cord-006229-7yoilsho	1689	55	regulation	regulation	NN
cord-006229-7yoilsho	1689	56	of	of	IN
cord-006229-7yoilsho	1689	57	this	this	DT
cord-006229-7yoilsho	1689	58	signaling	signal	VBG
cord-006229-7yoilsho	1689	59	cascade	cascade	NN
cord-006229-7yoilsho	1689	60	.	.	.
cord-006229-7yoilsho	1690	1	Conclusion	conclusion	NN
cord-006229-7yoilsho	1690	2	:	:	:
cord-006229-7yoilsho	1691	1	In	in	IN
cord-006229-7yoilsho	1691	2	summary	summary	NN
cord-006229-7yoilsho	1691	3	,	,	,
cord-006229-7yoilsho	1691	4	our	-PRON-	PRP$
cord-006229-7yoilsho	1691	5	data	datum	NNS
cord-006229-7yoilsho	1691	6	show	show	VBP
cord-006229-7yoilsho	1691	7	that	that	IN
cord-006229-7yoilsho	1691	8	p63RhoGEF	p63RhoGEF	NNP
cord-006229-7yoilsho	1691	9	regulates	regulate	VBZ
cord-006229-7yoilsho	1691	10	auto	auto	NN
cord-006229-7yoilsho	1691	11	-	-	HYPH
cord-006229-7yoilsho	1691	12	and	and	CC
cord-006229-7yoilsho	1691	13	paracrine	paracrine	JJ
cord-006229-7yoilsho	1691	14	signaling	signaling	NN
cord-006229-7yoilsho	1691	15	in	in	IN
cord-006229-7yoilsho	1691	16	cardiac	cardiac	JJ
cord-006229-7yoilsho	1691	17	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	1691	18	.	.	.
cord-006229-7yoilsho	1692	1	The	the	DT
cord-006229-7yoilsho	1692	2	atrophic	atrophic	JJ
cord-006229-7yoilsho	1692	3	rhinitis	rhinitis	NN
cord-006229-7yoilsho	1692	4	is	be	VBZ
cord-006229-7yoilsho	1692	5	characterized	characterize	VBN
cord-006229-7yoilsho	1692	6	by	by	IN
cord-006229-7yoilsho	1692	7	a	a	DT
cord-006229-7yoilsho	1692	8	drastic	drastic	JJ
cord-006229-7yoilsho	1692	9	destruction	destruction	NN
cord-006229-7yoilsho	1692	10	of	of	IN
cord-006229-7yoilsho	1692	11	nasal	nasal	NN
cord-006229-7yoilsho	1692	12	turbinate	turbinate	NN
cord-006229-7yoilsho	1692	13	bones	bone	NNS
cord-006229-7yoilsho	1692	14	in	in	IN
cord-006229-7yoilsho	1692	15	different	different	JJ
cord-006229-7yoilsho	1692	16	animals	animal	NNS
cord-006229-7yoilsho	1692	17	.	.	.
cord-006229-7yoilsho	1693	1	It	-PRON-	PRP
cord-006229-7yoilsho	1693	2	leads	lead	VBZ
cord-006229-7yoilsho	1693	3	to	to	IN
cord-006229-7yoilsho	1693	4	shortening	shorten	VBG
cord-006229-7yoilsho	1693	5	and	and	CC
cord-006229-7yoilsho	1693	6	twisting	twisting	NN
cord-006229-7yoilsho	1693	7	of	of	IN
cord-006229-7yoilsho	1693	8	the	the	DT
cord-006229-7yoilsho	1693	9	snout	snout	NN
cord-006229-7yoilsho	1693	10	and	and	CC
cord-006229-7yoilsho	1693	11	a	a	DT
cord-006229-7yoilsho	1693	12	growth	growth	NN
cord-006229-7yoilsho	1693	13	retardation	retardation	NN
cord-006229-7yoilsho	1693	14	of	of	IN
cord-006229-7yoilsho	1693	15	young	young	JJ
cord-006229-7yoilsho	1693	16	pigs	pig	NNS
cord-006229-7yoilsho	1693	17	.	.	.
cord-006229-7yoilsho	1694	1	This	this	DT
cord-006229-7yoilsho	1694	2	bone	bone	NN
cord-006229-7yoilsho	1694	3	degradation	degradation	NN
cord-006229-7yoilsho	1694	4	is	be	VBZ
cord-006229-7yoilsho	1694	5	induced	induce	VBN
cord-006229-7yoilsho	1694	6	by	by	IN
cord-006229-7yoilsho	1694	7	Pasteuralla	Pasteuralla	NNP
cord-006229-7yoilsho	1694	8	multocida	multocida	NNP
cord-006229-7yoilsho	1694	9	toxin	toxin	NN
cord-006229-7yoilsho	1694	10	(	(	-LRB-
cord-006229-7yoilsho	1694	11	PMT	PMT	NNP
cord-006229-7yoilsho	1694	12	)	)	-RRB-
cord-006229-7yoilsho	1694	13	,	,	,
cord-006229-7yoilsho	1694	14	a	a	DT
cord-006229-7yoilsho	1694	15	toxin	toxin	NN
cord-006229-7yoilsho	1694	16	produced	produce	VBN
cord-006229-7yoilsho	1694	17	by	by	IN
cord-006229-7yoilsho	1694	18	P.	P.	NNP
cord-006229-7yoilsho	1694	19	multocida	multocida	NNP
cord-006229-7yoilsho	1694	20	serogroups	serogroups	NNP
cord-006229-7yoilsho	1694	21	A	A	NNP
cord-006229-7yoilsho	1694	22	and	and	CC
cord-006229-7yoilsho	1694	23	D.	D.	NNP
cord-006229-7yoilsho	1695	1	This	this	DT
cord-006229-7yoilsho	1695	2	destructive	destructive	JJ
cord-006229-7yoilsho	1695	3	effect	effect	NN
cord-006229-7yoilsho	1695	4	indicates	indicate	VBZ
cord-006229-7yoilsho	1695	5	an	an	DT
cord-006229-7yoilsho	1695	6	interaction	interaction	NN
cord-006229-7yoilsho	1695	7	of	of	IN
cord-006229-7yoilsho	1695	8	PMT	pmt	NN
cord-006229-7yoilsho	1695	9	with	with	IN
cord-006229-7yoilsho	1695	10	bone	bone	NN
cord-006229-7yoilsho	1695	11	cells	cell	NNS
cord-006229-7yoilsho	1695	12	like	like	IN
cord-006229-7yoilsho	1695	13	osteoclasts	osteoclast	NNS
cord-006229-7yoilsho	1695	14	and	and	CC
cord-006229-7yoilsho	1695	15	osteoblasts	osteoblast	NNS
cord-006229-7yoilsho	1695	16	.	.	.
cord-006229-7yoilsho	1696	1	We	-PRON-	PRP
cord-006229-7yoilsho	1696	2	demonstrated	demonstrate	VBD
cord-006229-7yoilsho	1696	3	that	that	IN
cord-006229-7yoilsho	1696	4	PMT	PMT	NNP
cord-006229-7yoilsho	1696	5	stimulates	stimulate	VBZ
cord-006229-7yoilsho	1696	6	the	the	DT
cord-006229-7yoilsho	1696	7	differentiation	differentiation	NN
cord-006229-7yoilsho	1696	8	of	of	IN
cord-006229-7yoilsho	1696	9	osteoclasts	osteoclast	NNS
cord-006229-7yoilsho	1696	10	and	and	CC
cord-006229-7yoilsho	1696	11	inhibits	inhibit	VBZ
cord-006229-7yoilsho	1696	12	the	the	DT
cord-006229-7yoilsho	1696	13	differentiation	differentiation	NN
cord-006229-7yoilsho	1696	14	of	of	IN
cord-006229-7yoilsho	1696	15	osteoblasts	osteoblast	NNS
cord-006229-7yoilsho	1696	16	in	in	IN
cord-006229-7yoilsho	1696	17	a	a	DT
cord-006229-7yoilsho	1696	18	Gq	Gq	NNP
cord-006229-7yoilsho	1696	19	-	-	HYPH
cord-006229-7yoilsho	1696	20	dependent	dependent	JJ
cord-006229-7yoilsho	1696	21	mechanism	mechanism	NN
cord-006229-7yoilsho	1696	22	.	.	.
cord-006229-7yoilsho	1697	1	The	the	DT
cord-006229-7yoilsho	1697	2	underlying	underlying	JJ
cord-006229-7yoilsho	1697	3	molecular	molecular	JJ
cord-006229-7yoilsho	1697	4	mechanism	mechanism	NN
cord-006229-7yoilsho	1697	5	of	of	IN
cord-006229-7yoilsho	1697	6	the	the	DT
cord-006229-7yoilsho	1697	7	toxin	toxin	NN
cord-006229-7yoilsho	1697	8	is	be	VBZ
cord-006229-7yoilsho	1697	9	the	the	DT
cord-006229-7yoilsho	1697	10	deamidation	deamidation	NN
cord-006229-7yoilsho	1697	11	of	of	IN
cord-006229-7yoilsho	1697	12	an	an	DT
cord-006229-7yoilsho	1697	13	essential	essential	JJ
cord-006229-7yoilsho	1697	14	glutamine	glutamine	NN
cord-006229-7yoilsho	1697	15	residue	residue	NN
cord-006229-7yoilsho	1697	16	in	in	IN
cord-006229-7yoilsho	1697	17	the	the	DT
cord-006229-7yoilsho	1697	18	αsubunits	αsubunit	NNS
cord-006229-7yoilsho	1697	19	of	of	IN
cord-006229-7yoilsho	1697	20	heterotrimeric	heterotrimeric	NNP
cord-006229-7yoilsho	1697	21	G	G	NNP
cord-006229-7yoilsho	1697	22	proteins	protein	NNS
cord-006229-7yoilsho	1697	23	,	,	,
cord-006229-7yoilsho	1697	24	which	which	WDT
cord-006229-7yoilsho	1697	25	results	result	VBZ
cord-006229-7yoilsho	1697	26	in	in	IN
cord-006229-7yoilsho	1697	27	the	the	DT
cord-006229-7yoilsho	1697	28	constitutive	constitutive	JJ
cord-006229-7yoilsho	1697	29	activation	activation	NN
cord-006229-7yoilsho	1697	30	of	of	IN
cord-006229-7yoilsho	1697	31	the	the	DT
cord-006229-7yoilsho	1697	32	G	g	NN
cord-006229-7yoilsho	1697	33	protein	protein	NN
cord-006229-7yoilsho	1697	34	.	.	.
cord-006229-7yoilsho	1698	1	Until	until	IN
cord-006229-7yoilsho	1698	2	now	now	RB
cord-006229-7yoilsho	1698	3	only	only	RB
cord-006229-7yoilsho	1698	4	the	the	DT
cord-006229-7yoilsho	1698	5	function	function	NN
cord-006229-7yoilsho	1698	6	and	and	CC
cord-006229-7yoilsho	1698	7	the	the	DT
cord-006229-7yoilsho	1698	8	PMT	pmt	NN
cord-006229-7yoilsho	1698	9	-	-	HYPH
cord-006229-7yoilsho	1698	10	dependent	dependent	JJ
cord-006229-7yoilsho	1698	11	effects	effect	NNS
cord-006229-7yoilsho	1698	12	on	on	IN
cord-006229-7yoilsho	1698	13	osteoblasts	osteoblast	NNS
cord-006229-7yoilsho	1698	14	and	and	CC
cord-006229-7yoilsho	1698	15	osteoclasts	osteoclast	NNS
cord-006229-7yoilsho	1698	16	were	be	VBD
cord-006229-7yoilsho	1698	17	studied	study	VBN
cord-006229-7yoilsho	1698	18	in	in	IN
cord-006229-7yoilsho	1698	19	detail	detail	NN
cord-006229-7yoilsho	1698	20	,	,	,
cord-006229-7yoilsho	1698	21	but	but	CC
cord-006229-7yoilsho	1698	22	there	there	EX
cord-006229-7yoilsho	1698	23	is	be	VBZ
cord-006229-7yoilsho	1698	24	also	also	RB
cord-006229-7yoilsho	1698	25	a	a	DT
cord-006229-7yoilsho	1698	26	third	third	JJ
cord-006229-7yoilsho	1698	27	important	important	JJ
cord-006229-7yoilsho	1698	28	cell	cell	NN
cord-006229-7yoilsho	1698	29	type	type	NN
cord-006229-7yoilsho	1698	30	in	in	IN
cord-006229-7yoilsho	1698	31	bone	bone	NN
cord-006229-7yoilsho	1698	32	,	,	,
cord-006229-7yoilsho	1698	33	the	the	DT
cord-006229-7yoilsho	1698	34	osteocytes	osteocyte	NNS
cord-006229-7yoilsho	1698	35	.	.	.
cord-006229-7yoilsho	1699	1	Osteocytes	osteocyte	NNS
cord-006229-7yoilsho	1699	2	are	be	VBP
cord-006229-7yoilsho	1699	3	discussed	discuss	VBN
cord-006229-7yoilsho	1699	4	as	as	IN
cord-006229-7yoilsho	1699	5	the	the	DT
cord-006229-7yoilsho	1699	6	regulator	regulator	NN
cord-006229-7yoilsho	1699	7	of	of	IN
cord-006229-7yoilsho	1699	8	the	the	DT
cord-006229-7yoilsho	1699	9	bone	bone	NN
cord-006229-7yoilsho	1699	10	turn	turn	NN
cord-006229-7yoilsho	1699	11	-	-	HYPH
cord-006229-7yoilsho	1699	12	over	over	RP
cord-006229-7yoilsho	1699	13	by	by	IN
cord-006229-7yoilsho	1699	14	interacting	interact	VBG
cord-006229-7yoilsho	1699	15	with	with	IN
cord-006229-7yoilsho	1699	16	osteoclasts	osteoclast	NNS
cord-006229-7yoilsho	1699	17	and	and	CC
cord-006229-7yoilsho	1699	18	osteoblasts	osteoblast	NNS
cord-006229-7yoilsho	1700	1	e.g.	e.g.	RB
cord-006229-7yoilsho	1700	2	via	via	IN
cord-006229-7yoilsho	1700	3	secretion	secretion	NN
cord-006229-7yoilsho	1700	4	of	of	IN
cord-006229-7yoilsho	1700	5	several	several	JJ
cord-006229-7yoilsho	1700	6	osteoclastogenic	osteoclastogenic	JJ
cord-006229-7yoilsho	1700	7	and	and	CC
cord-006229-7yoilsho	1700	8	osteoblastogenic	osteoblastogenic	JJ
cord-006229-7yoilsho	1700	9	cytokines	cytokine	NNS
cord-006229-7yoilsho	1700	10	.	.	.
cord-006229-7yoilsho	1701	1	Therefore	therefore	RB
cord-006229-7yoilsho	1701	2	,	,	,
cord-006229-7yoilsho	1701	3	we	-PRON-	PRP
cord-006229-7yoilsho	1701	4	studied	study	VBD
cord-006229-7yoilsho	1701	5	the	the	DT
cord-006229-7yoilsho	1701	6	effects	effect	NNS
cord-006229-7yoilsho	1701	7	of	of	IN
cord-006229-7yoilsho	1701	8	PMT	pmt	NN
cord-006229-7yoilsho	1701	9	on	on	IN
cord-006229-7yoilsho	1701	10	the	the	DT
cord-006229-7yoilsho	1701	11	function	function	NN
cord-006229-7yoilsho	1701	12	of	of	IN
cord-006229-7yoilsho	1701	13	osteocytes	osteocyte	NNS
cord-006229-7yoilsho	1701	14	in	in	IN
cord-006229-7yoilsho	1701	15	more	more	JJR
cord-006229-7yoilsho	1701	16	detail	detail	NN
cord-006229-7yoilsho	1701	17	.	.	.
cord-006229-7yoilsho	1702	1	We	-PRON-	PRP
cord-006229-7yoilsho	1702	2	utilized	utilize	VBD
cord-006229-7yoilsho	1702	3	an	an	DT
cord-006229-7yoilsho	1702	4	osteocyte	osteocyte	NN
cord-006229-7yoilsho	1702	5	like	like	IN
cord-006229-7yoilsho	1702	6	cell	cell	NN
cord-006229-7yoilsho	1702	7	line	line	NN
cord-006229-7yoilsho	1702	8	and	and	CC
cord-006229-7yoilsho	1702	9	primary	primary	JJ
cord-006229-7yoilsho	1702	10	osteocytes	osteocyte	NNS
cord-006229-7yoilsho	1702	11	isolated	isolate	VBN
cord-006229-7yoilsho	1702	12	from	from	IN
cord-006229-7yoilsho	1702	13	tibiae	tibia	NNS
cord-006229-7yoilsho	1702	14	and	and	CC
cord-006229-7yoilsho	1702	15	femurs	femur	NNS
cord-006229-7yoilsho	1702	16	from	from	IN
cord-006229-7yoilsho	1702	17	mice	mouse	NNS
cord-006229-7yoilsho	1702	18	.	.	.
cord-006229-7yoilsho	1703	1	The	the	DT
cord-006229-7yoilsho	1703	2	susceptibility	susceptibility	NN
cord-006229-7yoilsho	1703	3	of	of	IN
cord-006229-7yoilsho	1703	4	primary	primary	JJ
cord-006229-7yoilsho	1703	5	osteocytes	osteocyte	NNS
cord-006229-7yoilsho	1703	6	and	and	CC
cord-006229-7yoilsho	1703	7	the	the	DT
cord-006229-7yoilsho	1703	8	osteocyte	osteocyte	NN
cord-006229-7yoilsho	1703	9	like	like	IN
cord-006229-7yoilsho	1703	10	cell	cell	NN
cord-006229-7yoilsho	1703	11	line	line	NN
cord-006229-7yoilsho	1703	12	towards	towards	IN
cord-006229-7yoilsho	1703	13	PMT	PMT	NNP
cord-006229-7yoilsho	1703	14	was	be	VBD
cord-006229-7yoilsho	1703	15	demonstrated	demonstrate	VBN
cord-006229-7yoilsho	1703	16	by	by	IN
cord-006229-7yoilsho	1703	17	detection	detection	NN
cord-006229-7yoilsho	1703	18	of	of	IN
cord-006229-7yoilsho	1703	19	toxin	toxin	NN
cord-006229-7yoilsho	1703	20	-	-	HYPH
cord-006229-7yoilsho	1703	21	induced	induce	VBN
cord-006229-7yoilsho	1703	22	deamidation	deamidation	NN
cord-006229-7yoilsho	1703	23	of	of	IN
cord-006229-7yoilsho	1703	24	G	g	NN
cord-006229-7yoilsho	1703	25	proteins	protein	NNS
cord-006229-7yoilsho	1703	26	.	.	.
cord-006229-7yoilsho	1704	1	We	-PRON-	PRP
cord-006229-7yoilsho	1704	2	also	also	RB
cord-006229-7yoilsho	1704	3	observed	observe	VBD
cord-006229-7yoilsho	1704	4	a	a	DT
cord-006229-7yoilsho	1704	5	PMT	pmt	NN
cord-006229-7yoilsho	1704	6	-	-	HYPH
cord-006229-7yoilsho	1704	7	induced	induce	VBN
cord-006229-7yoilsho	1704	8	secretion	secretion	NN
cord-006229-7yoilsho	1704	9	of	of	IN
cord-006229-7yoilsho	1704	10	different	different	JJ
cord-006229-7yoilsho	1704	11	cytokines	cytokine	NNS
cord-006229-7yoilsho	1704	12	,	,	,
cord-006229-7yoilsho	1704	13	like	like	IN
cord-006229-7yoilsho	1704	14	RANKL	RANKL	NNP
cord-006229-7yoilsho	1704	15	,	,	,
cord-006229-7yoilsho	1704	16	IL-6	IL-6	NNP
cord-006229-7yoilsho	1704	17	and	and	CC
cord-006229-7yoilsho	1704	18	TNF	TNF	NNP
cord-006229-7yoilsho	1704	19	-	-	HYPH
cord-006229-7yoilsho	1704	20	α	α	NNP
cord-006229-7yoilsho	1704	21	,	,	,
cord-006229-7yoilsho	1704	22	which	which	WDT
cord-006229-7yoilsho	1704	23	are	be	VBP
cord-006229-7yoilsho	1704	24	known	know	VBN
cord-006229-7yoilsho	1704	25	to	to	TO
cord-006229-7yoilsho	1704	26	induce	induce	VB
cord-006229-7yoilsho	1704	27	osteoclastogenesis	osteoclastogenesis	NN
cord-006229-7yoilsho	1704	28	or	or	CC
cord-006229-7yoilsho	1704	29	inhibit	inhibit	NN
cord-006229-7yoilsho	1704	30	osteoblastogenesis	osteoblastogenesis	NN
cord-006229-7yoilsho	1704	31	.	.	.
cord-006229-7yoilsho	1705	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	1705	2	,	,	,
cord-006229-7yoilsho	1705	3	we	-PRON-	PRP
cord-006229-7yoilsho	1705	4	studied	study	VBD
cord-006229-7yoilsho	1705	5	the	the	DT
cord-006229-7yoilsho	1705	6	underlying	underlie	VBG
cord-006229-7yoilsho	1705	7	signal	signal	NN
cord-006229-7yoilsho	1705	8	transduction	transduction	NN
cord-006229-7yoilsho	1705	9	pathways	pathway	NNS
cord-006229-7yoilsho	1705	10	and	and	CC
cord-006229-7yoilsho	1705	11	other	other	JJ
cord-006229-7yoilsho	1705	12	PMTinduced	pmtinduced	JJ
cord-006229-7yoilsho	1705	13	effects	effect	NNS
cord-006229-7yoilsho	1705	14	on	on	IN
cord-006229-7yoilsho	1705	15	osteocytes	osteocyte	NNS
cord-006229-7yoilsho	1705	16	,	,	,
cord-006229-7yoilsho	1705	17	like	like	IN
cord-006229-7yoilsho	1705	18	morphological	morphological	JJ
cord-006229-7yoilsho	1705	19	changes	change	NNS
cord-006229-7yoilsho	1705	20	.	.	.
cord-006229-7yoilsho	1706	1	In	in	IN
cord-006229-7yoilsho	1706	2	summary	summary	NN
cord-006229-7yoilsho	1706	3	,	,	,
cord-006229-7yoilsho	1706	4	we	-PRON-	PRP
cord-006229-7yoilsho	1706	5	show	show	VBP
cord-006229-7yoilsho	1706	6	that	that	IN
cord-006229-7yoilsho	1706	7	PMT	PMT	NNP
cord-006229-7yoilsho	1706	8	acts	act	VBZ
cord-006229-7yoilsho	1706	9	on	on	IN
cord-006229-7yoilsho	1706	10	osteocytes	osteocyte	NNS
cord-006229-7yoilsho	1706	11	by	by	IN
cord-006229-7yoilsho	1706	12	stimulating	stimulate	VBG
cord-006229-7yoilsho	1706	13	heterotrimeric	heterotrimeric	JJ
cord-006229-7yoilsho	1706	14	G	g	NN
cord-006229-7yoilsho	1706	15	proteins	protein	NNS
cord-006229-7yoilsho	1706	16	.	.	.
cord-006229-7yoilsho	1707	1	This	this	DT
cord-006229-7yoilsho	1707	2	might	may	MD
cord-006229-7yoilsho	1707	3	have	have	VB
cord-006229-7yoilsho	1707	4	impact	impact	NN
cord-006229-7yoilsho	1707	5	on	on	IN
cord-006229-7yoilsho	1707	6	overall	overall	JJ
cord-006229-7yoilsho	1707	7	bone	bone	NN
cord-006229-7yoilsho	1707	8	metabolism	metabolism	NN
cord-006229-7yoilsho	1707	9	due	due	IN
cord-006229-7yoilsho	1707	10	to	to	IN
cord-006229-7yoilsho	1707	11	modulation	modulation	NN
cord-006229-7yoilsho	1707	12	of	of	IN
cord-006229-7yoilsho	1707	13	osteoblast	osteoblast	NN
cord-006229-7yoilsho	1707	14	and	and	CC
cord-006229-7yoilsho	1707	15	osteoclast	osteoclast	JJ
cord-006229-7yoilsho	1707	16	activity	activity	NN
cord-006229-7yoilsho	1707	17	.	.	.
cord-006229-7yoilsho	1708	1	Pasteurella	Pasteurella	NNP
cord-006229-7yoilsho	1708	2	multocida	multocida	NNP
cord-006229-7yoilsho	1708	3	is	be	VBZ
cord-006229-7yoilsho	1708	4	an	an	DT
cord-006229-7yoilsho	1708	5	opportunistic	opportunistic	JJ
cord-006229-7yoilsho	1708	6	pathogen	pathogen	NN
cord-006229-7yoilsho	1708	7	often	often	RB
cord-006229-7yoilsho	1708	8	residing	reside	VBG
cord-006229-7yoilsho	1708	9	in	in	IN
cord-006229-7yoilsho	1708	10	the	the	DT
cord-006229-7yoilsho	1708	11	nasal	nasal	JJ
cord-006229-7yoilsho	1708	12	pharyngeal	pharyngeal	JJ
cord-006229-7yoilsho	1708	13	space	space	NN
cord-006229-7yoilsho	1708	14	of	of	IN
cord-006229-7yoilsho	1708	15	animals	animal	NNS
cord-006229-7yoilsho	1708	16	.	.	.
cord-006229-7yoilsho	1709	1	One	one	CD
cord-006229-7yoilsho	1709	2	virulence	virulence	NN
cord-006229-7yoilsho	1709	3	factor	factor	NN
cord-006229-7yoilsho	1709	4	of	of	IN
cord-006229-7yoilsho	1709	5	P.	P.	NNP
cord-006229-7yoilsho	1709	6	multocida	multocida	NNP
cord-006229-7yoilsho	1709	7	serogroups	serogroups	NNP
cord-006229-7yoilsho	1709	8	A	A	NNP
cord-006229-7yoilsho	1709	9	and	and	CC
cord-006229-7yoilsho	1709	10	D	D	NNP
cord-006229-7yoilsho	1709	11	is	be	VBZ
cord-006229-7yoilsho	1709	12	the	the	DT
cord-006229-7yoilsho	1709	13	protein	protein	NN
cord-006229-7yoilsho	1709	14	toxin	toxin	NN
cord-006229-7yoilsho	1709	15	PMT	PMT	NNP
cord-006229-7yoilsho	1709	16	(	(	-LRB-
cord-006229-7yoilsho	1709	17	P.	P.	NNP
cord-006229-7yoilsho	1709	18	multocida	multocida	NNP
cord-006229-7yoilsho	1709	19	toxin	toxin	NN
cord-006229-7yoilsho	1709	20	)	)	-RRB-
cord-006229-7yoilsho	1709	21	,	,	,
cord-006229-7yoilsho	1709	22	which	which	WDT
cord-006229-7yoilsho	1709	23	is	be	VBZ
cord-006229-7yoilsho	1709	24	the	the	DT
cord-006229-7yoilsho	1709	25	causative	causative	JJ
cord-006229-7yoilsho	1709	26	agent	agent	NN
cord-006229-7yoilsho	1709	27	of	of	IN
cord-006229-7yoilsho	1709	28	atrophic	atrophic	JJ
cord-006229-7yoilsho	1709	29	rhinitis	rhinitis	NN
cord-006229-7yoilsho	1709	30	characterized	characterize	VBN
cord-006229-7yoilsho	1709	31	by	by	IN
cord-006229-7yoilsho	1709	32	degradation	degradation	NN
cord-006229-7yoilsho	1709	33	of	of	IN
cord-006229-7yoilsho	1709	34	nasal	nasal	JJ
cord-006229-7yoilsho	1709	35	turbinate	turbinate	NN
cord-006229-7yoilsho	1709	36	bones	bone	NNS
cord-006229-7yoilsho	1709	37	in	in	IN
cord-006229-7yoilsho	1709	38	pigs	pig	NNS
cord-006229-7yoilsho	1709	39	and	and	CC
cord-006229-7yoilsho	1709	40	other	other	JJ
cord-006229-7yoilsho	1709	41	animals	animal	NNS
cord-006229-7yoilsho	1709	42	.	.	.
cord-006229-7yoilsho	1710	1	On	on	IN
cord-006229-7yoilsho	1710	2	the	the	DT
cord-006229-7yoilsho	1710	3	molecular	molecular	JJ
cord-006229-7yoilsho	1710	4	level	level	NN
cord-006229-7yoilsho	1710	5	,	,	,
cord-006229-7yoilsho	1710	6	PMT	PMT	NNP
cord-006229-7yoilsho	1710	7	activates	activate	VBZ
cord-006229-7yoilsho	1710	8	distinct	distinct	JJ
cord-006229-7yoilsho	1710	9	members	member	NNS
cord-006229-7yoilsho	1710	10	(	(	-LRB-
cord-006229-7yoilsho	1710	11	G	G	NNP
cord-006229-7yoilsho	1710	12	q/11	q/11	NNS
cord-006229-7yoilsho	1710	13	,	,	,
cord-006229-7yoilsho	1710	14	G	G	NNP
cord-006229-7yoilsho	1710	15	12/13	12/13	CD
cord-006229-7yoilsho	1710	16	and	and	CC
cord-006229-7yoilsho	1710	17	G	G	NNP
cord-006229-7yoilsho	1710	18	i	i	NNP
cord-006229-7yoilsho	1710	19	,	,	,
cord-006229-7yoilsho	1710	20	)	)	-RRB-
cord-006229-7yoilsho	1710	21	of	of	IN
cord-006229-7yoilsho	1710	22	heterotrimeric	heterotrimeric	NNP
cord-006229-7yoilsho	1710	23	G	G	NNP
cord-006229-7yoilsho	1710	24	proteins	protein	NNS
cord-006229-7yoilsho	1710	25	leading	lead	VBG
cord-006229-7yoilsho	1710	26	to	to	IN
cord-006229-7yoilsho	1710	27	a	a	DT
cord-006229-7yoilsho	1710	28	modulation	modulation	NN
cord-006229-7yoilsho	1710	29	of	of	IN
cord-006229-7yoilsho	1710	30	bone	bone	NN
cord-006229-7yoilsho	1710	31	metabolism	metabolism	NN
cord-006229-7yoilsho	1710	32	:	:	:
cord-006229-7yoilsho	1710	33	the	the	DT
cord-006229-7yoilsho	1710	34	toxin	toxin	NN
cord-006229-7yoilsho	1710	35	stimulates	stimulate	VBZ
cord-006229-7yoilsho	1710	36	osteoclastogenesis	osteoclastogenesis	NN
cord-006229-7yoilsho	1710	37	but	but	CC
cord-006229-7yoilsho	1710	38	blocks	block	VBZ
cord-006229-7yoilsho	1710	39	osteoblastogenesis	osteoblastogenesis	NNP
cord-006229-7yoilsho	1710	40	which	which	WDT
cord-006229-7yoilsho	1710	41	results	result	VBZ
cord-006229-7yoilsho	1710	42	in	in	IN
cord-006229-7yoilsho	1710	43	bone	bone	NN
cord-006229-7yoilsho	1710	44	loss	loss	NN
cord-006229-7yoilsho	1710	45	.	.	.
cord-006229-7yoilsho	1711	1	This	this	DT
cord-006229-7yoilsho	1711	2	mechanism	mechanism	NN
cord-006229-7yoilsho	1711	3	of	of	IN
cord-006229-7yoilsho	1711	4	action	action	NN
cord-006229-7yoilsho	1711	5	of	of	IN
cord-006229-7yoilsho	1711	6	PMT	PMT	NNP
cord-006229-7yoilsho	1711	7	might	may	MD
cord-006229-7yoilsho	1711	8	be	be	VB
cord-006229-7yoilsho	1711	9	exploited	exploit	VBN
cord-006229-7yoilsho	1711	10	to	to	TO
cord-006229-7yoilsho	1711	11	counteract	counteract	VB
cord-006229-7yoilsho	1711	12	the	the	DT
cord-006229-7yoilsho	1711	13	human	human	JJ
cord-006229-7yoilsho	1711	14	disease	disease	NN
cord-006229-7yoilsho	1711	15	fibrodysplasia	fibrodysplasia	NNP
cord-006229-7yoilsho	1711	16	ossificans	ossificans	NNP
cord-006229-7yoilsho	1711	17	progressiva	progressiva	NNP
cord-006229-7yoilsho	1711	18	(	(	-LRB-
cord-006229-7yoilsho	1711	19	FOP	FOP	NNP
cord-006229-7yoilsho	1711	20	)	)	-RRB-
cord-006229-7yoilsho	1711	21	,	,	,
cord-006229-7yoilsho	1711	22	a	a	DT
cord-006229-7yoilsho	1711	23	rare	rare	JJ
cord-006229-7yoilsho	1711	24	and	and	CC
cord-006229-7yoilsho	1711	25	highly	highly	RB
cord-006229-7yoilsho	1711	26	disabling	disabling	JJ
cord-006229-7yoilsho	1711	27	disorder	disorder	NN
cord-006229-7yoilsho	1711	28	of	of	IN
cord-006229-7yoilsho	1711	29	extensive	extensive	JJ
cord-006229-7yoilsho	1711	30	heterotopic	heterotopic	NNP
cord-006229-7yoilsho	1711	31	bone	bone	NN
cord-006229-7yoilsho	1711	32	growth	growth	NN
cord-006229-7yoilsho	1711	33	.	.	.
cord-006229-7yoilsho	1712	1	The	the	DT
cord-006229-7yoilsho	1712	2	underlying	underlying	JJ
cord-006229-7yoilsho	1712	3	cause	cause	NN
cord-006229-7yoilsho	1712	4	of	of	IN
cord-006229-7yoilsho	1712	5	FOP	fop	NN
cord-006229-7yoilsho	1712	6	is	be	VBZ
cord-006229-7yoilsho	1712	7	a	a	DT
cord-006229-7yoilsho	1712	8	point	point	NN
cord-006229-7yoilsho	1712	9	mutation	mutation	NN
cord-006229-7yoilsho	1712	10	in	in	IN
cord-006229-7yoilsho	1712	11	the	the	DT
cord-006229-7yoilsho	1712	12	activation	activation	NN
cord-006229-7yoilsho	1712	13	domain	domain	NN
cord-006229-7yoilsho	1712	14	of	of	IN
cord-006229-7yoilsho	1712	15	ACVR1	ACVR1	NNS
cord-006229-7yoilsho	1713	1	(	(	-LRB-
cord-006229-7yoilsho	1713	2	R206H	R206H	NNP
cord-006229-7yoilsho	1713	3	)	)	-RRB-
cord-006229-7yoilsho	1713	4	,	,	,
cord-006229-7yoilsho	1713	5	a	a	DT
cord-006229-7yoilsho	1713	6	BMP	bmp	NN
cord-006229-7yoilsho	1713	7	(	(	-LRB-
cord-006229-7yoilsho	1713	8	bone	bone	NN
cord-006229-7yoilsho	1713	9	morphogenic	morphogenic	JJ
cord-006229-7yoilsho	1713	10	protein	protein	NN
cord-006229-7yoilsho	1713	11	)	)	-RRB-
cord-006229-7yoilsho	1713	12	type	type	NN
cord-006229-7yoilsho	1713	13	1	1	CD
cord-006229-7yoilsho	1713	14	receptor	receptor	NN
cord-006229-7yoilsho	1713	15	.	.	.
cord-006229-7yoilsho	1714	1	This	this	DT
cord-006229-7yoilsho	1714	2	mutation	mutation	NN
cord-006229-7yoilsho	1714	3	leads	lead	VBZ
cord-006229-7yoilsho	1714	4	to	to	IN
cord-006229-7yoilsho	1714	5	an	an	DT
cord-006229-7yoilsho	1714	6	inflated	inflated	JJ
cord-006229-7yoilsho	1714	7	BMP	bmp	NN
cord-006229-7yoilsho	1714	8	-	-	HYPH
cord-006229-7yoilsho	1714	9	signaling	signal	VBG
cord-006229-7yoilsho	1714	10	and	and	CC
cord-006229-7yoilsho	1714	11	heterotopic	heterotopic	NNP
cord-006229-7yoilsho	1714	12	osteoblastogenesis	osteoblastogenesis	NNP
cord-006229-7yoilsho	1714	13	.	.	.
cord-006229-7yoilsho	1715	1	Here	here	RB
cord-006229-7yoilsho	1715	2	,	,	,
cord-006229-7yoilsho	1715	3	we	-PRON-	PRP
cord-006229-7yoilsho	1715	4	report	report	VBP
cord-006229-7yoilsho	1715	5	that	that	IN
cord-006229-7yoilsho	1715	6	C2C12	c2c12	JJ
cord-006229-7yoilsho	1715	7	cells	cell	NNS
cord-006229-7yoilsho	1715	8	,	,	,
cord-006229-7yoilsho	1715	9	a	a	DT
cord-006229-7yoilsho	1715	10	mouse	mouse	NN
cord-006229-7yoilsho	1715	11	myoblast	myoblast	NN
cord-006229-7yoilsho	1715	12	cell	cell	NN
cord-006229-7yoilsho	1715	13	line	line	NN
cord-006229-7yoilsho	1715	14	often	often	RB
cord-006229-7yoilsho	1715	15	used	use	VBN
cord-006229-7yoilsho	1715	16	as	as	IN
cord-006229-7yoilsho	1715	17	a	a	DT
cord-006229-7yoilsho	1715	18	FOP	FOP	NNP
cord-006229-7yoilsho	1715	19	model	model	NN
cord-006229-7yoilsho	1715	20	,	,	,
cord-006229-7yoilsho	1715	21	are	be	VBP
cord-006229-7yoilsho	1715	22	susceptible	susceptible	JJ
cord-006229-7yoilsho	1715	23	to	to	IN
cord-006229-7yoilsho	1715	24	PMT	pmt	NN
cord-006229-7yoilsho	1715	25	intoxication	intoxication	NN
cord-006229-7yoilsho	1715	26	.	.	.
cord-006229-7yoilsho	1716	1	PMT	PMT	NNP
cord-006229-7yoilsho	1716	2	induces	induce	VBZ
cord-006229-7yoilsho	1716	3	deamidation	deamidation	NN
cord-006229-7yoilsho	1716	4	of	of	IN
cord-006229-7yoilsho	1716	5	G	g	NN
cord-006229-7yoilsho	1716	6	proteins	protein	NNS
cord-006229-7yoilsho	1716	7	in	in	IN
cord-006229-7yoilsho	1716	8	these	these	DT
cord-006229-7yoilsho	1716	9	cells	cell	NNS
cord-006229-7yoilsho	1716	10	.	.	.
cord-006229-7yoilsho	1717	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	1717	2	,	,	,
cord-006229-7yoilsho	1717	3	PMT	PMT	NNP
cord-006229-7yoilsho	1717	4	very	very	RB
cord-006229-7yoilsho	1717	5	efficiently	efficiently	RB
cord-006229-7yoilsho	1717	6	inhibits	inhibit	VBZ
cord-006229-7yoilsho	1717	7	BMP4-induced	BMP4-induced	NNP
cord-006229-7yoilsho	1717	8	osteoblast	osteoblast	JJ
cord-006229-7yoilsho	1717	9	differentiation	differentiation	NN
cord-006229-7yoilsho	1717	10	in	in	IN
cord-006229-7yoilsho	1717	11	C2C12	c2c12	JJ
cord-006229-7yoilsho	1717	12	cells	cell	NNS
cord-006229-7yoilsho	1717	13	.	.	.
cord-006229-7yoilsho	1718	1	This	this	DT
cord-006229-7yoilsho	1718	2	has	have	VBZ
cord-006229-7yoilsho	1718	3	been	be	VBN
cord-006229-7yoilsho	1718	4	shown	show	VBN
cord-006229-7yoilsho	1718	5	by	by	IN
cord-006229-7yoilsho	1718	6	measuring	measure	VBG
cord-006229-7yoilsho	1718	7	alkaline	alkaline	JJ
cord-006229-7yoilsho	1718	8	phosphatase	phosphatase	NN
cord-006229-7yoilsho	1718	9	expression	expression	NN
cord-006229-7yoilsho	1718	10	which	which	WDT
cord-006229-7yoilsho	1718	11	is	be	VBZ
cord-006229-7yoilsho	1718	12	an	an	DT
cord-006229-7yoilsho	1718	13	early	early	JJ
cord-006229-7yoilsho	1718	14	marker	marker	NN
cord-006229-7yoilsho	1718	15	of	of	IN
cord-006229-7yoilsho	1718	16	osteoblast	osteoblast	JJ
cord-006229-7yoilsho	1718	17	differentiation	differentiation	NN
cord-006229-7yoilsho	1718	18	.	.	.
cord-006229-7yoilsho	1719	1	Additionally	additionally	RB
cord-006229-7yoilsho	1719	2	,	,	,
cord-006229-7yoilsho	1719	3	the	the	DT
cord-006229-7yoilsho	1719	4	impact	impact	NN
cord-006229-7yoilsho	1719	5	of	of	IN
cord-006229-7yoilsho	1719	6	PMT	PMT	NNP
cord-006229-7yoilsho	1719	7	on	on	IN
cord-006229-7yoilsho	1719	8	ACVR1	ACVR1	NNS
cord-006229-7yoilsho	1720	1	R206H	R206H	NNP
cord-006229-7yoilsho	1720	2	induced	induce	VBN
cord-006229-7yoilsho	1720	3	osteoblastogenesis	osteoblastogenesis	NN
cord-006229-7yoilsho	1720	4	will	will	MD
cord-006229-7yoilsho	1720	5	be	be	VB
cord-006229-7yoilsho	1720	6	investigated	investigate	VBN
cord-006229-7yoilsho	1720	7	and	and	CC
cord-006229-7yoilsho	1720	8	the	the	DT
cord-006229-7yoilsho	1720	9	involved	involved	JJ
cord-006229-7yoilsho	1720	10	cellular	cellular	JJ
cord-006229-7yoilsho	1720	11	signaling	signal	VBG
cord-006229-7yoilsho	1720	12	pathways	pathway	NNS
cord-006229-7yoilsho	1720	13	will	will	MD
cord-006229-7yoilsho	1720	14	be	be	VB
cord-006229-7yoilsho	1720	15	characterized	characterize	VBN
cord-006229-7yoilsho	1720	16	in	in	IN
cord-006229-7yoilsho	1720	17	detail	detail	NN
cord-006229-7yoilsho	1720	18	.	.	.
cord-006229-7yoilsho	1721	1	The	the	DT
cord-006229-7yoilsho	1721	2	data	datum	NNS
cord-006229-7yoilsho	1721	3	indicate	indicate	VBP
cord-006229-7yoilsho	1721	4	that	that	IN
cord-006229-7yoilsho	1721	5	activation	activation	NN
cord-006229-7yoilsho	1721	6	of	of	IN
cord-006229-7yoilsho	1721	7	heterotrimeric	heterotrimeric	NNP
cord-006229-7yoilsho	1721	8	G	G	NNP
cord-006229-7yoilsho	1721	9	-	-	HYPH
cord-006229-7yoilsho	1721	10	proteins	protein	NNS
cord-006229-7yoilsho	1721	11	might	may	MD
cord-006229-7yoilsho	1721	12	be	be	VB
cord-006229-7yoilsho	1721	13	a	a	DT
cord-006229-7yoilsho	1721	14	rationale	rationale	NN
cord-006229-7yoilsho	1721	15	for	for	IN
cord-006229-7yoilsho	1721	16	pharmacological	pharmacological	JJ
cord-006229-7yoilsho	1721	17	therapy	therapy	NN
cord-006229-7yoilsho	1721	18	of	of	IN
cord-006229-7yoilsho	1721	19	FOP	FOP	NNP
cord-006229-7yoilsho	1721	20	.	.	.
cord-006229-7yoilsho	1721	21	 	 	_SP
cord-006229-7yoilsho	1722	1	p63RhoGEF	p63rhogef	NN
cord-006229-7yoilsho	1722	2	is	be	VBZ
cord-006229-7yoilsho	1722	3	an	an	DT
cord-006229-7yoilsho	1722	4	activator	activator	NN
cord-006229-7yoilsho	1722	5	of	of	IN
cord-006229-7yoilsho	1722	6	the	the	DT
cord-006229-7yoilsho	1722	7	monomeric	monomeric	JJ
cord-006229-7yoilsho	1722	8	GTPase	GTPase	NNP
cord-006229-7yoilsho	1722	9	RhoA	RhoA	NNP
cord-006229-7yoilsho	1722	10	and	and	CC
cord-006229-7yoilsho	1722	11	was	be	VBD
cord-006229-7yoilsho	1722	12	shown	show	VBN
cord-006229-7yoilsho	1722	13	to	to	TO
cord-006229-7yoilsho	1722	14	be	be	VB
cord-006229-7yoilsho	1722	15	expressed	express	VBN
cord-006229-7yoilsho	1722	16	in	in	IN
cord-006229-7yoilsho	1722	17	the	the	DT
cord-006229-7yoilsho	1722	18	heart	heart	NN
cord-006229-7yoilsho	1722	19	.	.	.
cord-006229-7yoilsho	1723	1	In	in	IN
cord-006229-7yoilsho	1723	2	cardiac	cardiac	JJ
cord-006229-7yoilsho	1723	3	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	1723	4	and	and	CC
cord-006229-7yoilsho	1723	5	smooth	smooth	JJ
cord-006229-7yoilsho	1723	6	muscle	muscle	NN
cord-006229-7yoilsho	1723	7	cells	cell	NNS
cord-006229-7yoilsho	1723	8	,	,	,
cord-006229-7yoilsho	1723	9	p63RhoGEF	p63rhogef	NN
cord-006229-7yoilsho	1723	10	regulates	regulate	VBZ
cord-006229-7yoilsho	1723	11	RhoA	RhoA	NNP
cord-006229-7yoilsho	1723	12	in	in	IN
cord-006229-7yoilsho	1723	13	response	response	NN
cord-006229-7yoilsho	1723	14	to	to	IN
cord-006229-7yoilsho	1723	15	angiotensin	angiotensin	NN
cord-006229-7yoilsho	1723	16	II	II	NNP
cord-006229-7yoilsho	1723	17	and	and	CC
cord-006229-7yoilsho	1723	18	controls	control	VBZ
cord-006229-7yoilsho	1723	19	the	the	DT
cord-006229-7yoilsho	1723	20	actin	actin	NN
cord-006229-7yoilsho	1723	21	cytoskeleton	cytoskeleton	NN
cord-006229-7yoilsho	1723	22	as	as	RB
cord-006229-7yoilsho	1723	23	well	well	RB
cord-006229-7yoilsho	1723	24	as	as	IN
cord-006229-7yoilsho	1723	25	protein	protein	NN
cord-006229-7yoilsho	1723	26	expression	expression	NN
cord-006229-7yoilsho	1723	27	and	and	CC
cord-006229-7yoilsho	1723	28	secretion	secretion	NN
cord-006229-7yoilsho	1723	29	.	.	.
cord-006229-7yoilsho	1724	1	Its	-PRON-	PRP$
cord-006229-7yoilsho	1724	2	role	role	NN
cord-006229-7yoilsho	1724	3	in	in	IN
cord-006229-7yoilsho	1724	4	cardiomyocytes	cardiomyocyte	NNS
cord-006229-7yoilsho	1724	5	,	,	,
cord-006229-7yoilsho	1724	6	however	however	RB
cord-006229-7yoilsho	1724	7	,	,	,
cord-006229-7yoilsho	1724	8	has	have	VBZ
cord-006229-7yoilsho	1724	9	not	not	RB
cord-006229-7yoilsho	1724	10	been	be	VBN
cord-006229-7yoilsho	1724	11	elucidated	elucidate	VBN
cord-006229-7yoilsho	1724	12	so	so	RB
cord-006229-7yoilsho	1724	13	far	far	RB
cord-006229-7yoilsho	1724	14	.	.	.
cord-006229-7yoilsho	1725	1	Cardiomyocytes	cardiomyocyte	NNS
cord-006229-7yoilsho	1725	2	were	be	VBD
cord-006229-7yoilsho	1725	3	isolated	isolate	VBN
cord-006229-7yoilsho	1725	4	from	from	IN
cord-006229-7yoilsho	1725	5	neonatal	neonatal	JJ
cord-006229-7yoilsho	1725	6	rat	rat	NN
cord-006229-7yoilsho	1725	7	hearts	heart	NNS
cord-006229-7yoilsho	1725	8	(	(	-LRB-
cord-006229-7yoilsho	1725	9	NRCM	NRCM	NNP
cord-006229-7yoilsho	1725	10	)	)	-RRB-
cord-006229-7yoilsho	1725	11	,	,	,
cord-006229-7yoilsho	1725	12	wild	wild	JJ
cord-006229-7yoilsho	1725	13	type	type	NN
cord-006229-7yoilsho	1725	14	mouse	mouse	NN
cord-006229-7yoilsho	1725	15	hearts	heart	NNS
cord-006229-7yoilsho	1725	16	(	(	-LRB-
cord-006229-7yoilsho	1725	17	WT	WT	NNP
cord-006229-7yoilsho	1725	18	-	-	HYPH
cord-006229-7yoilsho	1725	19	AMCM	AMCM	NNP
cord-006229-7yoilsho	1725	20	)	)	-RRB-
cord-006229-7yoilsho	1725	21	and	and	CC
cord-006229-7yoilsho	1725	22	homozygous	homozygous	JJ
cord-006229-7yoilsho	1725	23	(	(	-LRB-
cord-006229-7yoilsho	1725	24	KO	KO	NNP
cord-006229-7yoilsho	1725	25	-	-	HYPH
cord-006229-7yoilsho	1725	26	AMCM	AMCM	NNP
cord-006229-7yoilsho	1725	27	)	)	-RRB-
cord-006229-7yoilsho	1725	28	p63RhoGEF	p63rhogef	JJ
cord-006229-7yoilsho	1725	29	knockout	knockout	NN
cord-006229-7yoilsho	1725	30	mouse	mouse	NN
cord-006229-7yoilsho	1725	31	hearts	heart	NNS
cord-006229-7yoilsho	1725	32	.	.	.
cord-006229-7yoilsho	1726	1	The	the	DT
cord-006229-7yoilsho	1726	2	cells	cell	NNS
cord-006229-7yoilsho	1726	3	were	be	VBD
cord-006229-7yoilsho	1726	4	either	either	CC
cord-006229-7yoilsho	1726	5	directly	directly	RB
cord-006229-7yoilsho	1726	6	fixed	fix	VBN
cord-006229-7yoilsho	1726	7	or	or	CC
cord-006229-7yoilsho	1726	8	adenovirally	adenovirally	RB
cord-006229-7yoilsho	1726	9	transduced	transduce	VBN
cord-006229-7yoilsho	1726	10	for	for	IN
cord-006229-7yoilsho	1726	11	48	48	CD
cord-006229-7yoilsho	1726	12	h	h	NN
cord-006229-7yoilsho	1726	13	in	in	IN
cord-006229-7yoilsho	1726	14	culture	culture	NN
cord-006229-7yoilsho	1726	15	.	.	.
cord-006229-7yoilsho	1727	1	For	for	IN
cord-006229-7yoilsho	1727	2	activation	activation	NN
cord-006229-7yoilsho	1727	3	of	of	IN
cord-006229-7yoilsho	1727	4	the	the	DT
cord-006229-7yoilsho	1727	5	G	g	NN
cord-006229-7yoilsho	1727	6	q/11	q/11	NNPS
cord-006229-7yoilsho	1727	7	-signaling	-signale	VBG
cord-006229-7yoilsho	1727	8	the	the	DT
cord-006229-7yoilsho	1727	9	cells	cell	NNS
cord-006229-7yoilsho	1727	10	were	be	VBD
cord-006229-7yoilsho	1727	11	treated	treat	VBN
cord-006229-7yoilsho	1727	12	with	with	IN
cord-006229-7yoilsho	1727	13	endothelin-1	endothelin-1	NNP
cord-006229-7yoilsho	1727	14	(	(	-LRB-
cord-006229-7yoilsho	1727	15	ET-1	ET-1	NNP
cord-006229-7yoilsho	1727	16	)	)	-RRB-
cord-006229-7yoilsho	1727	17	,	,	,
cord-006229-7yoilsho	1727	18	angiotensin	angiotensin	NN
cord-006229-7yoilsho	1727	19	II	II	NNP
cord-006229-7yoilsho	1727	20	(	(	-LRB-
cord-006229-7yoilsho	1727	21	Ang	Ang	NNP
cord-006229-7yoilsho	1727	22	II	II	NNP
cord-006229-7yoilsho	1727	23	)	)	-RRB-
cord-006229-7yoilsho	1727	24	or	or	CC
cord-006229-7yoilsho	1727	25	phenylephrine	phenylephrine	NNP
cord-006229-7yoilsho	1727	26	(	(	-LRB-
cord-006229-7yoilsho	1727	27	PE	PE	NNP
cord-006229-7yoilsho	1727	28	)	)	-RRB-
cord-006229-7yoilsho	1727	29	for	for	IN
cord-006229-7yoilsho	1727	30	90	90	CD
cord-006229-7yoilsho	1727	31	s.	s.	NNP
cord-006229-7yoilsho	1727	32	RhoA	RhoA	NNP
cord-006229-7yoilsho	1727	33	activation	activation	NN
cord-006229-7yoilsho	1727	34	was	be	VBD
cord-006229-7yoilsho	1727	35	assessed	assess	VBN
cord-006229-7yoilsho	1727	36	by	by	IN
cord-006229-7yoilsho	1727	37	affinity	affinity	NN
cord-006229-7yoilsho	1727	38	binding	binding	NN
cord-006229-7yoilsho	1727	39	or	or	CC
cord-006229-7yoilsho	1727	40	with	with	IN
cord-006229-7yoilsho	1727	41	a	a	DT
cord-006229-7yoilsho	1727	42	specific	specific	JJ
cord-006229-7yoilsho	1727	43	active	active	JJ
cord-006229-7yoilsho	1727	44	-	-	HYPH
cord-006229-7yoilsho	1727	45	RhoA	RhoA	NNP
cord-006229-7yoilsho	1727	46	antibody	antibody	NN
cord-006229-7yoilsho	1727	47	.	.	.
cord-006229-7yoilsho	1728	1	Other	other	JJ
cord-006229-7yoilsho	1728	2	proteins	protein	NNS
cord-006229-7yoilsho	1728	3	were	be	VBD
cord-006229-7yoilsho	1728	4	detected	detect	VBN
cord-006229-7yoilsho	1728	5	by	by	IN
cord-006229-7yoilsho	1728	6	immunoblot	immunoblot	NNP
cord-006229-7yoilsho	1728	7	or	or	CC
cord-006229-7yoilsho	1728	8	immunofluorescence	immunofluorescence	NN
cord-006229-7yoilsho	1728	9	analysis	analysis	NN
cord-006229-7yoilsho	1728	10	with	with	IN
cord-006229-7yoilsho	1728	11	subsequent	subsequent	JJ
cord-006229-7yoilsho	1728	12	confocal	confocal	JJ
cord-006229-7yoilsho	1728	13	imaging	imaging	NN
cord-006229-7yoilsho	1728	14	.	.	.
cord-006229-7yoilsho	1729	1	In	in	IN
cord-006229-7yoilsho	1729	2	NRCM	NRCM	NNP
cord-006229-7yoilsho	1729	3	p63RhoGEF	p63RhoGEF	NNP
cord-006229-7yoilsho	1729	4	is	be	VBZ
cord-006229-7yoilsho	1729	5	involved	involve	VBN
cord-006229-7yoilsho	1729	6	in	in	IN
cord-006229-7yoilsho	1729	7	the	the	DT
cord-006229-7yoilsho	1729	8	regulation	regulation	NN
cord-006229-7yoilsho	1729	9	of	of	IN
cord-006229-7yoilsho	1729	10	the	the	DT
cord-006229-7yoilsho	1729	11	ET-1-induced	et-1-induced	CD
cord-006229-7yoilsho	1729	12	RhoA	RhoA	NNP
cord-006229-7yoilsho	1729	13	activity	activity	NN
cord-006229-7yoilsho	1729	14	and	and	CC
cord-006229-7yoilsho	1729	15	thus	thus	RB
cord-006229-7yoilsho	1729	16	increases	increase	VBZ
cord-006229-7yoilsho	1729	17	the	the	DT
cord-006229-7yoilsho	1729	18	expression	expression	NN
cord-006229-7yoilsho	1729	19	and	and	CC
cord-006229-7yoilsho	1729	20	secretion	secretion	NN
cord-006229-7yoilsho	1729	21	of	of	IN
cord-006229-7yoilsho	1729	22	the	the	DT
cord-006229-7yoilsho	1729	23	RhoA	RhoA	NNP
cord-006229-7yoilsho	1729	24	target	target	NN
cord-006229-7yoilsho	1729	25	gene	gene	NN
cord-006229-7yoilsho	1729	26	CTGF	CTGF	NNP
cord-006229-7yoilsho	1729	27	.	.	.
cord-006229-7yoilsho	1730	1	In	in	IN
cord-006229-7yoilsho	1730	2	accordance	accordance	NN
cord-006229-7yoilsho	1730	3	,	,	,
cord-006229-7yoilsho	1730	4	p63RhoGEF	p63rhogef	NN
cord-006229-7yoilsho	1730	5	was	be	VBD
cord-006229-7yoilsho	1730	6	found	find	VBN
cord-006229-7yoilsho	1730	7	to	to	TO
cord-006229-7yoilsho	1730	8	be	be	VB
cord-006229-7yoilsho	1730	9	localized	localize	VBN
cord-006229-7yoilsho	1730	10	at	at	IN
cord-006229-7yoilsho	1730	11	the	the	DT
cord-006229-7yoilsho	1730	12	sarcolemma	sarcolemma	NNP
cord-006229-7yoilsho	1730	13	as	as	RB
cord-006229-7yoilsho	1730	14	well	well	RB
cord-006229-7yoilsho	1730	15	as	as	IN
cord-006229-7yoilsho	1730	16	in	in	IN
cord-006229-7yoilsho	1730	17	intracellular	intracellular	JJ
cord-006229-7yoilsho	1730	18	membrane	membrane	NN
cord-006229-7yoilsho	1730	19	compartments	compartment	NNS
cord-006229-7yoilsho	1730	20	.	.	.
cord-006229-7yoilsho	1731	1	The	the	DT
cord-006229-7yoilsho	1731	2	strongest	strong	JJS
cord-006229-7yoilsho	1731	3	co	co	NN
cord-006229-7yoilsho	1731	4	-	-	NN
cord-006229-7yoilsho	1731	5	localization	localization	NN
cord-006229-7yoilsho	1731	6	was	be	VBD
cord-006229-7yoilsho	1731	7	detected	detect	VBN
cord-006229-7yoilsho	1731	8	with	with	IN
cord-006229-7yoilsho	1731	9	the	the	DT
cord-006229-7yoilsho	1731	10	KDEL	KDEL	NNP
cord-006229-7yoilsho	1731	11	-	-	HYPH
cord-006229-7yoilsho	1731	12	receptor	receptor	NN
cord-006229-7yoilsho	1731	13	3	3	CD
cord-006229-7yoilsho	1731	14	(	(	-LRB-
cord-006229-7yoilsho	1731	15	KDELR3	KDELR3	NNP
cord-006229-7yoilsho	1731	16	)	)	-RRB-
cord-006229-7yoilsho	1731	17	which	which	WDT
cord-006229-7yoilsho	1731	18	resides	reside	VBZ
cord-006229-7yoilsho	1731	19	in	in	IN
cord-006229-7yoilsho	1731	20	the	the	DT
cord-006229-7yoilsho	1731	21	endoplasmatic	endoplasmatic	JJ
cord-006229-7yoilsho	1731	22	reticulum	reticulum	NN
cord-006229-7yoilsho	1731	23	membrane	membrane	NN
cord-006229-7yoilsho	1731	24	.	.	.
cord-006229-7yoilsho	1732	1	Next	next	RB
cord-006229-7yoilsho	1732	2	,	,	,
cord-006229-7yoilsho	1732	3	we	-PRON-	PRP
cord-006229-7yoilsho	1732	4	analyzed	analyze	VBD
cord-006229-7yoilsho	1732	5	RhoA	RhoA	NNP
cord-006229-7yoilsho	1732	6	activation	activation	NN
cord-006229-7yoilsho	1732	7	in	in	IN
cord-006229-7yoilsho	1732	8	WT	WT	NNP
cord-006229-7yoilsho	1732	9	and	and	CC
cord-006229-7yoilsho	1732	10	KO	KO	NNP
cord-006229-7yoilsho	1732	11	-	-	HYPH
cord-006229-7yoilsho	1732	12	AMCM	AMCM	NNP
cord-006229-7yoilsho	1732	13	and	and	CC
cord-006229-7yoilsho	1732	14	could	could	MD
cord-006229-7yoilsho	1732	15	show	show	VB
cord-006229-7yoilsho	1732	16	that	that	IN
cord-006229-7yoilsho	1732	17	a	a	DT
cord-006229-7yoilsho	1732	18	loss	loss	NN
cord-006229-7yoilsho	1732	19	of	of	IN
cord-006229-7yoilsho	1732	20	p63RhoGEF	p63rhogef	NN
cord-006229-7yoilsho	1732	21	led	lead	VBD
cord-006229-7yoilsho	1732	22	to	to	IN
cord-006229-7yoilsho	1732	23	an	an	DT
cord-006229-7yoilsho	1732	24	increase	increase	NN
cord-006229-7yoilsho	1732	25	in	in	IN
cord-006229-7yoilsho	1732	26	basal	basal	NN
cord-006229-7yoilsho	1732	27	RhoA	RhoA	NNP
cord-006229-7yoilsho	1732	28	activity	activity	NN
cord-006229-7yoilsho	1732	29	and	and	CC
cord-006229-7yoilsho	1732	30	an	an	DT
cord-006229-7yoilsho	1732	31	uncoupling	uncoupling	NN
cord-006229-7yoilsho	1732	32	from	from	IN
cord-006229-7yoilsho	1732	33	the	the	DT
cord-006229-7yoilsho	1732	34	GPCRs	gpcr	NNS
cord-006229-7yoilsho	1732	35	.	.	.
cord-006229-7yoilsho	1733	1	Interestingly	interestingly	RB
cord-006229-7yoilsho	1733	2	,	,	,
cord-006229-7yoilsho	1733	3	in	in	IN
cord-006229-7yoilsho	1733	4	the	the	DT
cord-006229-7yoilsho	1733	5	KO	KO	NNP
cord-006229-7yoilsho	1733	6	-	-	HYPH
cord-006229-7yoilsho	1733	7	AMCM	AMCM	NNP
cord-006229-7yoilsho	1733	8	caveolin-3	caveolin-3	NNP
cord-006229-7yoilsho	1733	9	the	the	DT
cord-006229-7yoilsho	1733	10	major	major	JJ
cord-006229-7yoilsho	1733	11	component	component	NN
cord-006229-7yoilsho	1733	12	of	of	IN
cord-006229-7yoilsho	1733	13	caveolae	caveolae	NNP
cord-006229-7yoilsho	1733	14	,	,	,
cord-006229-7yoilsho	1733	15	in	in	IN
cord-006229-7yoilsho	1733	16	which	which	WDT
cord-006229-7yoilsho	1733	17	several	several	JJ
cord-006229-7yoilsho	1733	18	GPCRs	gpcr	NNS
cord-006229-7yoilsho	1733	19	are	be	VBP
cord-006229-7yoilsho	1733	20	clustered	cluster	VBN
cord-006229-7yoilsho	1733	21	,	,	,
cord-006229-7yoilsho	1733	22	was	be	VBD
cord-006229-7yoilsho	1733	23	reduced	reduce	VBN
cord-006229-7yoilsho	1733	24	in	in	IN
cord-006229-7yoilsho	1733	25	its	-PRON-	PRP$
cord-006229-7yoilsho	1733	26	expression	expression	NN
cord-006229-7yoilsho	1733	27	and	and	CC
cord-006229-7yoilsho	1733	28	a	a	DT
cord-006229-7yoilsho	1733	29	shift	shift	NN
cord-006229-7yoilsho	1733	30	in	in	IN
cord-006229-7yoilsho	1733	31	localization	localization	NN
cord-006229-7yoilsho	1733	32	from	from	IN
cord-006229-7yoilsho	1733	33	transverse	transverse	JJ
cord-006229-7yoilsho	1733	34	to	to	IN
cord-006229-7yoilsho	1733	35	longitudinal	longitudinal	JJ
cord-006229-7yoilsho	1733	36	membrane	membrane	NN
cord-006229-7yoilsho	1733	37	tubules	tubule	NNS
cord-006229-7yoilsho	1733	38	was	be	VBD
cord-006229-7yoilsho	1733	39	found	find	VBN
cord-006229-7yoilsho	1733	40	,	,	,
cord-006229-7yoilsho	1733	41	arguing	argue	VBG
cord-006229-7yoilsho	1733	42	for	for	IN
cord-006229-7yoilsho	1733	43	a	a	DT
cord-006229-7yoilsho	1733	44	role	role	NN
cord-006229-7yoilsho	1733	45	of	of	IN
cord-006229-7yoilsho	1733	46	p63RhoGEF	p63rhogef	CD
cord-006229-7yoilsho	1733	47	in	in	IN
cord-006229-7yoilsho	1733	48	intracellular	intracellular	JJ
cord-006229-7yoilsho	1733	49	protein	protein	NN
cord-006229-7yoilsho	1733	50	transport	transport	NN
cord-006229-7yoilsho	1733	51	.	.	.
cord-006229-7yoilsho	1734	1	In	in	IN
cord-006229-7yoilsho	1734	2	accordance	accordance	NN
cord-006229-7yoilsho	1734	3	,	,	,
cord-006229-7yoilsho	1734	4	Golgi	Golgi	NNP
cord-006229-7yoilsho	1734	5	apparatus	apparatus	NN
cord-006229-7yoilsho	1734	6	particles	particle	NNS
cord-006229-7yoilsho	1734	7	,	,	,
cord-006229-7yoilsho	1734	8	which	which	WDT
cord-006229-7yoilsho	1734	9	were	be	VBD
cord-006229-7yoilsho	1734	10	demonstrated	demonstrate	VBN
cord-006229-7yoilsho	1734	11	to	to	TO
cord-006229-7yoilsho	1734	12	play	play	VB
cord-006229-7yoilsho	1734	13	role	role	NN
cord-006229-7yoilsho	1734	14	in	in	IN
cord-006229-7yoilsho	1734	15	caveolae	caveolae	NNP
cord-006229-7yoilsho	1734	16	formation	formation	NN
cord-006229-7yoilsho	1734	17	,	,	,
cord-006229-7yoilsho	1734	18	were	be	VBD
cord-006229-7yoilsho	1734	19	reduced	reduce	VBN
cord-006229-7yoilsho	1734	20	in	in	IN
cord-006229-7yoilsho	1734	21	size	size	NN
cord-006229-7yoilsho	1734	22	in	in	IN
cord-006229-7yoilsho	1734	23	KO	KO	NNP
cord-006229-7yoilsho	1734	24	-	-	HYPH
cord-006229-7yoilsho	1734	25	AMCM	AMCM	NNP
cord-006229-7yoilsho	1734	26	.	.	.
cord-006229-7yoilsho	1735	1	To	to	TO
cord-006229-7yoilsho	1735	2	further	further	RB
cord-006229-7yoilsho	1735	3	address	address	VB
cord-006229-7yoilsho	1735	4	the	the	DT
cord-006229-7yoilsho	1735	5	role	role	NN
cord-006229-7yoilsho	1735	6	of	of	IN
cord-006229-7yoilsho	1735	7	p63RhoGEF	p63rhogef	CD
cord-006229-7yoilsho	1735	8	in	in	IN
cord-006229-7yoilsho	1735	9	the	the	DT
cord-006229-7yoilsho	1735	10	transport	transport	NN
cord-006229-7yoilsho	1735	11	of	of	IN
cord-006229-7yoilsho	1735	12	membrane	membrane	NN
cord-006229-7yoilsho	1735	13	proteins	protein	NNS
cord-006229-7yoilsho	1735	14	,	,	,
cord-006229-7yoilsho	1735	15	we	-PRON-	PRP
cord-006229-7yoilsho	1735	16	overexpressed	overexpresse	VBD
cord-006229-7yoilsho	1735	17	p63RhoGEF	p63rhogef	CD
cord-006229-7yoilsho	1735	18	in	in	IN
cord-006229-7yoilsho	1735	19	WT	WT	NNP
cord-006229-7yoilsho	1735	20	-	-	HYPH
cord-006229-7yoilsho	1735	21	AMCM	AMCM	NNP
cord-006229-7yoilsho	1735	22	and	and	CC
cord-006229-7yoilsho	1735	23	could	could	MD
cord-006229-7yoilsho	1735	24	show	show	VB
cord-006229-7yoilsho	1735	25	that	that	IN
cord-006229-7yoilsho	1735	26	this	this	DT
cord-006229-7yoilsho	1735	27	led	lead	VBD
cord-006229-7yoilsho	1735	28	to	to	IN
cord-006229-7yoilsho	1735	29	an	an	DT
cord-006229-7yoilsho	1735	30	increase	increase	NN
cord-006229-7yoilsho	1735	31	in	in	IN
cord-006229-7yoilsho	1735	32	the	the	DT
cord-006229-7yoilsho	1735	33	expression	expression	NN
cord-006229-7yoilsho	1735	34	of	of	IN
cord-006229-7yoilsho	1735	35	the	the	DT
cord-006229-7yoilsho	1735	36	KDELR3	KDELR3	NNS
cord-006229-7yoilsho	1735	37	and	and	CC
cord-006229-7yoilsho	1735	38	its	-PRON-	PRP$
cord-006229-7yoilsho	1735	39	co	co	NN
cord-006229-7yoilsho	1735	40	-	-	NN
cord-006229-7yoilsho	1735	41	localization	localization	NN
cord-006229-7yoilsho	1735	42	with	with	IN
cord-006229-7yoilsho	1735	43	p63RhoGEF	p63rhogef	CD
cord-006229-7yoilsho	1735	44	in	in	IN
cord-006229-7yoilsho	1735	45	the	the	DT
cord-006229-7yoilsho	1735	46	perinuclear	perinuclear	NNP
cord-006229-7yoilsho	1735	47	region	region	NN
cord-006229-7yoilsho	1735	48	and	and	CC
cord-006229-7yoilsho	1735	49	at	at	IN
cord-006229-7yoilsho	1735	50	the	the	DT
cord-006229-7yoilsho	1735	51	sarcolemma	sarcolemma	NNP
cord-006229-7yoilsho	1735	52	.	.	.
cord-006229-7yoilsho	1736	1	No	no	DT
cord-006229-7yoilsho	1736	2	sarcolemmal	sarcolemmal	NNP
cord-006229-7yoilsho	1736	3	localization	localization	NN
cord-006229-7yoilsho	1736	4	of	of	IN
cord-006229-7yoilsho	1736	5	KDELR3	KDELR3	NNP
cord-006229-7yoilsho	1736	6	was	be	VBD
cord-006229-7yoilsho	1736	7	found	find	VBN
cord-006229-7yoilsho	1736	8	in	in	IN
cord-006229-7yoilsho	1736	9	control	control	NN
cord-006229-7yoilsho	1736	10	-	-	HYPH
cord-006229-7yoilsho	1736	11	transduced	transduce	VBN
cord-006229-7yoilsho	1736	12	cells	cell	NNS
cord-006229-7yoilsho	1736	13	.	.	.
cord-006229-7yoilsho	1737	1	Further	further	RB
cord-006229-7yoilsho	1737	2	,	,	,
cord-006229-7yoilsho	1737	3	p63RhoGEF	p63rhogef	NN
cord-006229-7yoilsho	1737	4	was	be	VBD
cord-006229-7yoilsho	1737	5	localized	localize	VBN
cord-006229-7yoilsho	1737	6	adjacent	adjacent	JJ
cord-006229-7yoilsho	1737	7	to	to	IN
cord-006229-7yoilsho	1737	8	Golgi	Golgi	NNP
cord-006229-7yoilsho	1737	9	apparatus	apparatus	NN
cord-006229-7yoilsho	1737	10	particles	particle	NNS
cord-006229-7yoilsho	1737	11	which	which	WDT
cord-006229-7yoilsho	1737	12	were	be	VBD
cord-006229-7yoilsho	1737	13	similar	similar	JJ
cord-006229-7yoilsho	1737	14	reduced	reduce	VBN
cord-006229-7yoilsho	1737	15	in	in	IN
cord-006229-7yoilsho	1737	16	size	size	NN
cord-006229-7yoilsho	1737	17	as	as	IN
cord-006229-7yoilsho	1737	18	detected	detect	VBN
cord-006229-7yoilsho	1737	19	in	in	IN
cord-006229-7yoilsho	1737	20	the	the	DT
cord-006229-7yoilsho	1737	21	KO	KO	NNP
cord-006229-7yoilsho	1737	22	-	-	HYPH
cord-006229-7yoilsho	1737	23	AMCM	AMCM	NNP
cord-006229-7yoilsho	1737	24	.	.	.
cord-006229-7yoilsho	1738	1	Finally	finally	RB
cord-006229-7yoilsho	1738	2	,	,	,
cord-006229-7yoilsho	1738	3	we	-PRON-	PRP
cord-006229-7yoilsho	1738	4	expressed	express	VBD
cord-006229-7yoilsho	1738	5	the	the	DT
cord-006229-7yoilsho	1738	6	dominant	dominant	JJ
cord-006229-7yoilsho	1738	7	negative	negative	JJ
cord-006229-7yoilsho	1738	8	construct	construct	NN
cord-006229-7yoilsho	1738	9	p63DN	p63dn	NN
cord-006229-7yoilsho	1738	10	and	and	CC
cord-006229-7yoilsho	1738	11	detected	detect	VBD
cord-006229-7yoilsho	1738	12	similar	similar	JJ
cord-006229-7yoilsho	1738	13	changes	change	NNS
cord-006229-7yoilsho	1738	14	with	with	IN
cord-006229-7yoilsho	1738	15	respect	respect	NN
cord-006229-7yoilsho	1738	16	to	to	IN
cord-006229-7yoilsho	1738	17	KDELR3	kdelr3	NN
cord-006229-7yoilsho	1738	18	localization	localization	NN
cord-006229-7yoilsho	1738	19	and	and	CC
cord-006229-7yoilsho	1738	20	Golgi	Golgi	NNP
cord-006229-7yoilsho	1738	21	structure	structure	NN
cord-006229-7yoilsho	1738	22	suggesting	suggest	VBG
cord-006229-7yoilsho	1738	23	that	that	IN
cord-006229-7yoilsho	1738	24	this	this	DT
cord-006229-7yoilsho	1738	25	regulatory	regulatory	JJ
cord-006229-7yoilsho	1738	26	function	function	NN
cord-006229-7yoilsho	1738	27	of	of	IN
cord-006229-7yoilsho	1738	28	p63RhoGEF	p63rhogef	NN
cord-006229-7yoilsho	1738	29	is	be	VBZ
cord-006229-7yoilsho	1738	30	not	not	RB
cord-006229-7yoilsho	1738	31	dependent	dependent	JJ
cord-006229-7yoilsho	1738	32	on	on	IN
cord-006229-7yoilsho	1738	33	its	-PRON-	PRP$
cord-006229-7yoilsho	1738	34	activity	activity	NN
cord-006229-7yoilsho	1738	35	.	.	.
cord-006229-7yoilsho	1739	1	Conclusion	conclusion	NN
cord-006229-7yoilsho	1739	2	:	:	:
cord-006229-7yoilsho	1739	3	p63RhoGEF	p63rhogef	NN
cord-006229-7yoilsho	1739	4	mediates	mediate	VBZ
cord-006229-7yoilsho	1739	5	the	the	DT
cord-006229-7yoilsho	1739	6	activation	activation	NN
cord-006229-7yoilsho	1739	7	of	of	IN
cord-006229-7yoilsho	1739	8	RhoA	RhoA	NNP
cord-006229-7yoilsho	1739	9	from	from	IN
cord-006229-7yoilsho	1739	10	GPCRs	gpcr	NNS
cord-006229-7yoilsho	1739	11	coupled	couple	VBN
cord-006229-7yoilsho	1739	12	to	to	IN
cord-006229-7yoilsho	1739	13	G	g	NN
cord-006229-7yoilsho	1739	14	q/11	q/11	NNS
cord-006229-7yoilsho	1739	15	proteins	protein	NNS
cord-006229-7yoilsho	1739	16	.	.	.
cord-006229-7yoilsho	1740	1	Moreover	moreover	RB
cord-006229-7yoilsho	1740	2	,	,	,
cord-006229-7yoilsho	1740	3	it	-PRON-	PRP
cord-006229-7yoilsho	1740	4	has	have	VBZ
cord-006229-7yoilsho	1740	5	a	a	DT
cord-006229-7yoilsho	1740	6	function	function	NN
cord-006229-7yoilsho	1740	7	in	in	IN
cord-006229-7yoilsho	1740	8	intracellular	intracellular	JJ
cord-006229-7yoilsho	1740	9	transport	transport	NN
cord-006229-7yoilsho	1740	10	and	and	CC
cord-006229-7yoilsho	1740	11	distribution	distribution	NN
cord-006229-7yoilsho	1740	12	of	of	IN
cord-006229-7yoilsho	1740	13	membrane	membrane	NN
cord-006229-7yoilsho	1740	14	proteins	protein	NNS
cord-006229-7yoilsho	1740	15	independent	independent	JJ
cord-006229-7yoilsho	1740	16	of	of	IN
cord-006229-7yoilsho	1740	17	its	-PRON-	PRP$
cord-006229-7yoilsho	1740	18	activity	activity	NN
cord-006229-7yoilsho	1740	19	.	.	.
cord-006229-7yoilsho	1741	1	Universität	Universität	NNP
cord-006229-7yoilsho	1741	2	Bonn	Bonn	NNP
cord-006229-7yoilsho	1741	3	,	,	,
cord-006229-7yoilsho	1741	4	Pharmacology	Pharmacology	NNP
cord-006229-7yoilsho	1741	5	and	and	CC
cord-006229-7yoilsho	1741	6	Toxicology	Toxicology	NNP
cord-006229-7yoilsho	1741	7	Section	Section	NNP
cord-006229-7yoilsho	1741	8	,	,	,
cord-006229-7yoilsho	1741	9	Bonn	Bonn	NNP
cord-006229-7yoilsho	1741	10	,	,	,
cord-006229-7yoilsho	1742	1	Germany	Germany	NNP
cord-006229-7yoilsho	1742	2	G	G	NNP
cord-006229-7yoilsho	1742	3	protein	protein	NN
cord-006229-7yoilsho	1742	4	signaling	signaling	NN
cord-006229-7yoilsho	1742	5	is	be	VBZ
cord-006229-7yoilsho	1742	6	a	a	DT
cord-006229-7yoilsho	1742	7	means	means	NN
cord-006229-7yoilsho	1742	8	allowing	allow	VBG
cord-006229-7yoilsho	1742	9	cells	cell	NNS
cord-006229-7yoilsho	1742	10	to	to	TO
cord-006229-7yoilsho	1742	11	quickly	quickly	RB
cord-006229-7yoilsho	1742	12	respond	respond	VB
cord-006229-7yoilsho	1742	13	and	and	CC
cord-006229-7yoilsho	1742	14	adapt	adapt	VB
cord-006229-7yoilsho	1742	15	to	to	IN
cord-006229-7yoilsho	1742	16	environmental	environmental	JJ
cord-006229-7yoilsho	1742	17	changes	change	NNS
cord-006229-7yoilsho	1742	18	.	.	.
cord-006229-7yoilsho	1743	1	Four	four	CD
cord-006229-7yoilsho	1743	2	major	major	JJ
cord-006229-7yoilsho	1743	3	G	g	NN
cord-006229-7yoilsho	1743	4	protein	protein	NN
cord-006229-7yoilsho	1743	5	classes	class	NNS
cord-006229-7yoilsho	1743	6	(	(	-LRB-
cord-006229-7yoilsho	1743	7	Gs	Gs	NNP
cord-006229-7yoilsho	1743	8	,	,	,
cord-006229-7yoilsho	1743	9	Gi	Gi	NNP
cord-006229-7yoilsho	1743	10	/	/	SYM
cord-006229-7yoilsho	1743	11	o	o	NN
cord-006229-7yoilsho	1743	12	,	,	,
cord-006229-7yoilsho	1743	13	Gq/11	Gq/11	NNP
cord-006229-7yoilsho	1743	14	,	,	,
cord-006229-7yoilsho	1743	15	G12/13	g12/13	NN
cord-006229-7yoilsho	1743	16	)	)	-RRB-
cord-006229-7yoilsho	1743	17	exist	exist	VBP
cord-006229-7yoilsho	1743	18	in	in	IN
cord-006229-7yoilsho	1743	19	mammals	mammal	NNS
cord-006229-7yoilsho	1743	20	and	and	CC
cord-006229-7yoilsho	1743	21	these	these	DT
cord-006229-7yoilsho	1743	22	must	must	MD
cord-006229-7yoilsho	1743	23	suffice	suffice	VB
cord-006229-7yoilsho	1743	24	to	to	TO
cord-006229-7yoilsho	1743	25	convey	convey	VB
cord-006229-7yoilsho	1743	26	signals	signal	NNS
cord-006229-7yoilsho	1743	27	from	from	IN
cord-006229-7yoilsho	1743	28	about	about	RB
cord-006229-7yoilsho	1743	29	800	800	CD
cord-006229-7yoilsho	1743	30	G	g	NN
cord-006229-7yoilsho	1743	31	protein	protein	NN
cord-006229-7yoilsho	1743	32	-	-	HYPH
cord-006229-7yoilsho	1743	33	coupled	couple	VBN
cord-006229-7yoilsho	1743	34	receptors	receptor	NNS
cord-006229-7yoilsho	1743	35	to	to	IN
cord-006229-7yoilsho	1743	36	the	the	DT
cord-006229-7yoilsho	1743	37	cell	cell	NN
cord-006229-7yoilsho	1743	38	interior	interior	NN
cord-006229-7yoilsho	1743	39	.	.	.
cord-006229-7yoilsho	1744	1	As	as	IN
cord-006229-7yoilsho	1744	2	such	such	JJ
cord-006229-7yoilsho	1744	3	,	,	,
cord-006229-7yoilsho	1744	4	G	g	NN
cord-006229-7yoilsho	1744	5	proteins	protein	NNS
cord-006229-7yoilsho	1744	6	receive	receive	VBP
cord-006229-7yoilsho	1744	7	,	,	,
cord-006229-7yoilsho	1744	8	interpret	interpret	VBP
cord-006229-7yoilsho	1744	9	,	,	,
cord-006229-7yoilsho	1744	10	and	and	CC
cord-006229-7yoilsho	1744	11	finally	finally	RB
cord-006229-7yoilsho	1744	12	route	route	VB
cord-006229-7yoilsho	1744	13	the	the	DT
cord-006229-7yoilsho	1744	14	GPCR	GPCR	NNP
cord-006229-7yoilsho	1744	15	signals	signal	NNS
cord-006229-7yoilsho	1744	16	to	to	IN
cord-006229-7yoilsho	1744	17	diverse	diverse	JJ
cord-006229-7yoilsho	1744	18	sets	set	NNS
cord-006229-7yoilsho	1744	19	of	of	IN
cord-006229-7yoilsho	1744	20	downstream	downstream	JJ
cord-006229-7yoilsho	1744	21	target	target	NN
cord-006229-7yoilsho	1744	22	proteins	protein	NNS
cord-006229-7yoilsho	1744	23	and	and	CC
cord-006229-7yoilsho	1744	24	thereby	thereby	RB
cord-006229-7yoilsho	1744	25	permit	permit	VBP
cord-006229-7yoilsho	1744	26	cells	cell	NNS
cord-006229-7yoilsho	1744	27	to	to	TO
cord-006229-7yoilsho	1744	28	respond	respond	VB
cord-006229-7yoilsho	1744	29	to	to	IN
cord-006229-7yoilsho	1744	30	their	-PRON-	PRP$
cord-006229-7yoilsho	1744	31	ever	ever	RB
cord-006229-7yoilsho	1744	32	changing	change	VBG
cord-006229-7yoilsho	1744	33	environment	environment	NN
cord-006229-7yoilsho	1744	34	.	.	.
cord-006229-7yoilsho	1745	1	1	1	LS
cord-006229-7yoilsho	1746	1	Understanding	understand	VBG
cord-006229-7yoilsho	1746	2	contribution	contribution	NN
cord-006229-7yoilsho	1746	3	of	of	IN
cord-006229-7yoilsho	1746	4	individual	individual	JJ
cord-006229-7yoilsho	1746	5	G	g	NN
cord-006229-7yoilsho	1746	6	protein	protein	NN
cord-006229-7yoilsho	1746	7	classes	class	NNS
cord-006229-7yoilsho	1746	8	or	or	CC
cord-006229-7yoilsho	1746	9	even	even	RB
cord-006229-7yoilsho	1746	10	isoforms	isoform	NNS
cord-006229-7yoilsho	1746	11	to	to	TO
cord-006229-7yoilsho	1746	12	complex	complex	VB
cord-006229-7yoilsho	1746	13	signaling	signal	VBG
cord-006229-7yoilsho	1746	14	networks	network	NNS
cord-006229-7yoilsho	1746	15	in	in	IN
cord-006229-7yoilsho	1746	16	living	living	NN
cord-006229-7yoilsho	1746	17	cells	cell	NNS
cord-006229-7yoilsho	1746	18	requires	require	VBZ
cord-006229-7yoilsho	1746	19	capacity	capacity	NN
cord-006229-7yoilsho	1746	20	to	to	TO
cord-006229-7yoilsho	1746	21	activate	activate	VB
cord-006229-7yoilsho	1746	22	or	or	CC
cord-006229-7yoilsho	1746	23	inactivate	inactivate	VB
cord-006229-7yoilsho	1746	24	proteins	protein	NNS
cord-006229-7yoilsho	1746	25	with	with	IN
cord-006229-7yoilsho	1746	26	great	great	JJ
cord-006229-7yoilsho	1746	27	precision	precision	NN
cord-006229-7yoilsho	1746	28	and	and	CC
cord-006229-7yoilsho	1746	29	selectivity	selectivity	NN
cord-006229-7yoilsho	1746	30	.	.	.
cord-006229-7yoilsho	1747	1	One	one	CD
cord-006229-7yoilsho	1747	2	approach	approach	NN
cord-006229-7yoilsho	1747	3	towards	towards	IN
cord-006229-7yoilsho	1747	4	inactivation	inactivation	NN
cord-006229-7yoilsho	1747	5	of	of	IN
cord-006229-7yoilsho	1747	6	G	g	NN
cord-006229-7yoilsho	1747	7	protein	protein	NN
cord-006229-7yoilsho	1747	8	function	function	NN
cord-006229-7yoilsho	1747	9	is	be	VBZ
cord-006229-7yoilsho	1747	10	via	via	IN
cord-006229-7yoilsho	1747	11	chemical	chemical	JJ
cord-006229-7yoilsho	1747	12	inhibition	inhibition	NN
cord-006229-7yoilsho	1747	13	.	.	.
cord-006229-7yoilsho	1748	1	However	however	RB
cord-006229-7yoilsho	1748	2	,	,	,
cord-006229-7yoilsho	1748	3	"	"	``
cord-006229-7yoilsho	1748	4	true	true	JJ
cord-006229-7yoilsho	1748	5	specificity	specificity	NN
cord-006229-7yoilsho	1748	6	"	"	''
cord-006229-7yoilsho	1748	7	of	of	IN
cord-006229-7yoilsho	1748	8	chemical	chemical	NN
cord-006229-7yoilsho	1748	9	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	1748	10	for	for	IN
cord-006229-7yoilsho	1748	11	their	-PRON-	PRP$
cord-006229-7yoilsho	1748	12	associated	associate	VBN
cord-006229-7yoilsho	1748	13	targets	target	NNS
cord-006229-7yoilsho	1748	14	may	may	MD
cord-006229-7yoilsho	1748	15	often	often	RB
cord-006229-7yoilsho	1748	16	be	be	VB
cord-006229-7yoilsho	1748	17	debated	debate	VBN
cord-006229-7yoilsho	1748	18	.	.	.
cord-006229-7yoilsho	1749	1	In	in	IN
cord-006229-7yoilsho	1749	2	this	this	DT
cord-006229-7yoilsho	1749	3	study	study	NN
cord-006229-7yoilsho	1749	4	we	-PRON-	PRP
cord-006229-7yoilsho	1749	5	posit	posit	VBP
cord-006229-7yoilsho	1749	6	that	that	IN
cord-006229-7yoilsho	1749	7	FR900359	fr900359	NN
cord-006229-7yoilsho	1749	8	,	,	,
cord-006229-7yoilsho	1749	9	a	a	DT
cord-006229-7yoilsho	1749	10	cyclic	cyclic	JJ
cord-006229-7yoilsho	1749	11	depsipeptide	depsipeptide	NN
cord-006229-7yoilsho	1749	12	isolated	isolate	VBN
cord-006229-7yoilsho	1749	13	from	from	IN
cord-006229-7yoilsho	1749	14	the	the	DT
cord-006229-7yoilsho	1749	15	leaves	leave	NNS
cord-006229-7yoilsho	1749	16	of	of	IN
cord-006229-7yoilsho	1749	17	Ardisia	Ardisia	NNP
cord-006229-7yoilsho	1749	18	crenata	crenata	NNP
cord-006229-7yoilsho	1749	19	,	,	,
cord-006229-7yoilsho	1749	20	may	may	MD
cord-006229-7yoilsho	1749	21	clearly	clearly	RB
cord-006229-7yoilsho	1749	22	be	be	VB
cord-006229-7yoilsho	1749	23	designated	designate	VBN
cord-006229-7yoilsho	1749	24	as	as	IN
cord-006229-7yoilsho	1749	25	"	"	``
cord-006229-7yoilsho	1749	26	truly	truly	RB
cord-006229-7yoilsho	1749	27	specific	specific	JJ
cord-006229-7yoilsho	1749	28	"	"	''
cord-006229-7yoilsho	1749	29	for	for	IN
cord-006229-7yoilsho	1749	30	inhibition	inhibition	NN
cord-006229-7yoilsho	1749	31	of	of	IN
cord-006229-7yoilsho	1749	32	Gq	Gq	NNP
cord-006229-7yoilsho	1749	33	signaling	signal	VBG
cord-006229-7yoilsho	1749	34	.	.	.
cord-006229-7yoilsho	1750	1	Using	use	VBG
cord-006229-7yoilsho	1750	2	a	a	DT
cord-006229-7yoilsho	1750	3	broad	broad	JJ
cord-006229-7yoilsho	1750	4	set	set	NN
cord-006229-7yoilsho	1750	5	of	of	IN
cord-006229-7yoilsho	1750	6	complementary	complementary	JJ
cord-006229-7yoilsho	1750	7	methods	method	NNS
cord-006229-7yoilsho	1750	8	based	base	VBN
cord-006229-7yoilsho	1750	9	on	on	IN
cord-006229-7yoilsho	1750	10	label	label	NN
cord-006229-7yoilsho	1750	11	-	-	HYPH
cord-006229-7yoilsho	1750	12	free	free	JJ
cord-006229-7yoilsho	1750	13	holistic	holistic	JJ
cord-006229-7yoilsho	1750	14	cell	cell	NN
cord-006229-7yoilsho	1750	15	sensing	sensing	NN
cord-006229-7yoilsho	1750	16	,	,	,
cord-006229-7yoilsho	1750	17	classical	classical	JJ
cord-006229-7yoilsho	1750	18	endpoint	endpoint	NN
cord-006229-7yoilsho	1750	19	assays	assay	NNS
cord-006229-7yoilsho	1750	20	,	,	,
cord-006229-7yoilsho	1750	21	and	and	CC
cord-006229-7yoilsho	1750	22	bioluminescence	bioluminescence	NN
cord-006229-7yoilsho	1750	23	resonance	resonance	NN
cord-006229-7yoilsho	1750	24	energy	energy	NN
cord-006229-7yoilsho	1750	25	transferbased	transferbase	VBD
cord-006229-7yoilsho	1750	26	G	G	NNP
cord-006229-7yoilsho	1750	27	protein	protein	NN
cord-006229-7yoilsho	1750	28	biosensors	biosensor	NNS
cord-006229-7yoilsho	1750	29	we	-PRON-	PRP
cord-006229-7yoilsho	1750	30	assign	assign	VBP
cord-006229-7yoilsho	1750	31	exceptional	exceptional	JJ
cord-006229-7yoilsho	1750	32	selectivity	selectivity	NN
cord-006229-7yoilsho	1750	33	to	to	IN
cord-006229-7yoilsho	1750	34	FR	fr	NN
cord-006229-7yoilsho	1750	35	for	for	IN
cord-006229-7yoilsho	1750	36	inhibition	inhibition	NN
cord-006229-7yoilsho	1750	37	of	of	IN
cord-006229-7yoilsho	1750	38	Gq/11/14	Gq/11/14	NNP
cord-006229-7yoilsho	1750	39	over	over	IN
cord-006229-7yoilsho	1750	40	all	all	DT
cord-006229-7yoilsho	1750	41	other	other	JJ
cord-006229-7yoilsho	1750	42	mammalian	mammalian	JJ
cord-006229-7yoilsho	1750	43	isoforms	isoform	NNS
cord-006229-7yoilsho	1750	44	(	(	-LRB-
cord-006229-7yoilsho	1750	45	"	"	``
cord-006229-7yoilsho	1750	46	on	on	IN
cord-006229-7yoilsho	1750	47	-	-	HYPH
cord-006229-7yoilsho	1750	48	target	target	NN
cord-006229-7yoilsho	1750	49	effects	effect	NNS
cord-006229-7yoilsho	1750	50	"	"	''
cord-006229-7yoilsho	1750	51	)	)	-RRB-
cord-006229-7yoilsho	1750	52	.	.	.
cord-006229-7yoilsho	1751	1	In	in	IN
cord-006229-7yoilsho	1751	2	holistic	holistic	JJ
cord-006229-7yoilsho	1751	3	label	label	NN
cord-006229-7yoilsho	1751	4	-	-	HYPH
cord-006229-7yoilsho	1751	5	free	free	JJ
cord-006229-7yoilsho	1751	6	recordings	recording	NNS
cord-006229-7yoilsho	1751	7	using	use	VBG
cord-006229-7yoilsho	1751	8	HEK293	HEK293	NNP
cord-006229-7yoilsho	1751	9	cells	cell	NNS
cord-006229-7yoilsho	1751	10	that	that	WDT
cord-006229-7yoilsho	1751	11	lack	lack	VBP
cord-006229-7yoilsho	1751	12	functional	functional	JJ
cord-006229-7yoilsho	1751	13	Gq/11	Gq/11	NNS
cord-006229-7yoilsho	1751	14	alleles	allele	NNS
cord-006229-7yoilsho	1751	15	by	by	IN
cord-006229-7yoilsho	1751	16	CRISPR	CRISPR	NNP
cord-006229-7yoilsho	1751	17	-	-	HYPH
cord-006229-7yoilsho	1751	18	Cas9	Cas9	NNP
cord-006229-7yoilsho	1751	19	genome	genome	NN
cord-006229-7yoilsho	1751	20	editing	editing	NN
cord-006229-7yoilsho	1751	21	,	,	,
cord-006229-7yoilsho	1751	22	bona	bona	NN
cord-006229-7yoilsho	1751	23	-	-	HYPH
cord-006229-7yoilsho	1751	24	fide	fide	JJ
cord-006229-7yoilsho	1751	25	Gq	Gq	NNP
cord-006229-7yoilsho	1751	26	stimuli	stimulus	NNS
cord-006229-7yoilsho	1751	27	were	be	VBD
cord-006229-7yoilsho	1751	28	undetectable	undetectable	JJ
cord-006229-7yoilsho	1751	29	.	.	.
cord-006229-7yoilsho	1752	1	However	however	RB
cord-006229-7yoilsho	1752	2	,	,	,
cord-006229-7yoilsho	1752	3	reintroduction	reintroduction	NN
cord-006229-7yoilsho	1752	4	of	of	IN
cord-006229-7yoilsho	1752	5	Gq	Gq	NNP
cord-006229-7yoilsho	1752	6	into	into	IN
cord-006229-7yoilsho	1752	7	the	the	DT
cord-006229-7yoilsho	1752	8	knockout	knockout	NN
cord-006229-7yoilsho	1752	9	background	background	NN
cord-006229-7yoilsho	1752	10	was	be	VBD
cord-006229-7yoilsho	1752	11	required	require	VBN
cord-006229-7yoilsho	1752	12	and	and	CC
cord-006229-7yoilsho	1752	13	sufficient	sufficient	JJ
cord-006229-7yoilsho	1752	14	to	to	TO
cord-006229-7yoilsho	1752	15	fully	fully	RB
cord-006229-7yoilsho	1752	16	restore	restore	VB
cord-006229-7yoilsho	1752	17	both	both	DT
cord-006229-7yoilsho	1752	18	,	,	,
cord-006229-7yoilsho	1752	19	agonist	agonist	NN
cord-006229-7yoilsho	1752	20	responses	response	NNS
cord-006229-7yoilsho	1752	21	and	and	CC
cord-006229-7yoilsho	1752	22	their	-PRON-	PRP$
cord-006229-7yoilsho	1752	23	inhibition	inhibition	NN
cord-006229-7yoilsho	1752	24	by	by	IN
cord-006229-7yoilsho	1752	25	FR	FR	NNP
cord-006229-7yoilsho	1752	26	.	.	.
cord-006229-7yoilsho	1753	1	Moreover	moreover	RB
cord-006229-7yoilsho	1753	2	,	,	,
cord-006229-7yoilsho	1753	3	FR	FR	NNP
cord-006229-7yoilsho	1753	4	was	be	VBD
cord-006229-7yoilsho	1753	5	completely	completely	RB
cord-006229-7yoilsho	1753	6	ineffective	ineffective	JJ
cord-006229-7yoilsho	1753	7	in	in	IN
cord-006229-7yoilsho	1753	8	cells	cell	NNS
cord-006229-7yoilsho	1753	9	lacking	lack	VBG
cord-006229-7yoilsho	1753	10	Gq/11	Gq/11	NNS
cord-006229-7yoilsho	1753	11	using	use	VBG
cord-006229-7yoilsho	1753	12	phenotypic	phenotypic	JJ
cord-006229-7yoilsho	1753	13	assays	assay	NNS
cord-006229-7yoilsho	1753	14	that	that	WDT
cord-006229-7yoilsho	1753	15	examine	examine	VBP
cord-006229-7yoilsho	1753	16	basic	basic	JJ
cord-006229-7yoilsho	1753	17	cellular	cellular	JJ
cord-006229-7yoilsho	1753	18	functions	function	NNS
cord-006229-7yoilsho	1753	19	such	such	JJ
cord-006229-7yoilsho	1753	20	as	as	IN
cord-006229-7yoilsho	1753	21	cell	cell	NN
cord-006229-7yoilsho	1753	22	growth	growth	NN
cord-006229-7yoilsho	1753	23	,	,	,
cord-006229-7yoilsho	1753	24	viability	viability	NN
cord-006229-7yoilsho	1753	25	,	,	,
cord-006229-7yoilsho	1753	26	morphology	morphology	NN
cord-006229-7yoilsho	1753	27	and	and	CC
cord-006229-7yoilsho	1753	28	expression	expression	NN
cord-006229-7yoilsho	1753	29	of	of	IN
cord-006229-7yoilsho	1753	30	housekeeping	housekeeping	NN
cord-006229-7yoilsho	1753	31	genes	gene	NNS
cord-006229-7yoilsho	1753	32	(	(	-LRB-
cord-006229-7yoilsho	1753	33	"	"	``
cord-006229-7yoilsho	1753	34	off	off	IN
cord-006229-7yoilsho	1753	35	-	-	HYPH
cord-006229-7yoilsho	1753	36	target	target	NN
cord-006229-7yoilsho	1753	37	effects	effect	NNS
cord-006229-7yoilsho	1753	38	"	"	''
cord-006229-7yoilsho	1753	39	)	)	-RRB-
cord-006229-7yoilsho	1753	40	2	2	CD
cord-006229-7yoilsho	1753	41	.	.	.
cord-006229-7yoilsho	1754	1	From	from	IN
cord-006229-7yoilsho	1754	2	these	these	DT
cord-006229-7yoilsho	1754	3	results	result	NNS
cord-006229-7yoilsho	1754	4	we	-PRON-	PRP
cord-006229-7yoilsho	1754	5	conclude	conclude	VBP
cord-006229-7yoilsho	1754	6	that	that	IN
cord-006229-7yoilsho	1754	7	FR	FR	NNP
cord-006229-7yoilsho	1754	8	is	be	VBZ
cord-006229-7yoilsho	1754	9	of	of	IN
cord-006229-7yoilsho	1754	10	outstanding	outstanding	JJ
cord-006229-7yoilsho	1754	11	value	value	NN
cord-006229-7yoilsho	1754	12	as	as	IN
cord-006229-7yoilsho	1754	13	molecular	molecular	JJ
cord-006229-7yoilsho	1754	14	probe	probe	NN
cord-006229-7yoilsho	1754	15	to	to	TO
cord-006229-7yoilsho	1754	16	unravel	unravel	VB
cord-006229-7yoilsho	1754	17	contribution	contribution	NN
cord-006229-7yoilsho	1754	18	of	of	IN
cord-006229-7yoilsho	1754	19	Gq	Gq	NNP
cord-006229-7yoilsho	1754	20	signaling	signal	VBG
cord-006229-7yoilsho	1754	21	in	in	IN
cord-006229-7yoilsho	1754	22	complex	complex	JJ
cord-006229-7yoilsho	1754	23	biological	biological	JJ
cord-006229-7yoilsho	1754	24	processes	process	NNS
cord-006229-7yoilsho	1754	25	in	in	IN
cord-006229-7yoilsho	1754	26	vitro	vitro	FW
cord-006229-7yoilsho	1754	27	,	,	,
cord-006229-7yoilsho	1754	28	ex	ex	NN
cord-006229-7yoilsho	1754	29	vivo	vivo	NN
cord-006229-7yoilsho	1754	30	and	and	CC
cord-006229-7yoilsho	1754	31	in	in	IN
cord-006229-7yoilsho	1754	32	vivo	vivo	NNP
cord-006229-7yoilsho	1754	33	.	.	.
cord-006229-7yoilsho	1755	1	Just	just	RB
cord-006229-7yoilsho	1755	2	as	as	IN
cord-006229-7yoilsho	1755	3	pertussis	pertussis	NN
cord-006229-7yoilsho	1755	4	toxin	toxin	NN
cord-006229-7yoilsho	1755	5	,	,	,
cord-006229-7yoilsho	1755	6	applied	apply	VBN
cord-006229-7yoilsho	1755	7	world	world	NN
cord-006229-7yoilsho	1755	8	-	-	HYPH
cord-006229-7yoilsho	1755	9	wide	wide	RB
cord-006229-7yoilsho	1755	10	by	by	IN
cord-006229-7yoilsho	1755	11	numerous	numerous	JJ
cord-006229-7yoilsho	1755	12	laboratories	laboratory	NNS
cord-006229-7yoilsho	1755	13	to	to	TO
cord-006229-7yoilsho	1755	14	diagnose	diagnose	VB
cord-006229-7yoilsho	1755	15	signaling	signal	VBG
cord-006229-7yoilsho	1755	16	of	of	IN
cord-006229-7yoilsho	1755	17	Gi	Gi	NNP
cord-006229-7yoilsho	1755	18	/	/	SYM
cord-006229-7yoilsho	1755	19	o	o	NN
cord-006229-7yoilsho	1755	20	proteins	protein	NNS
cord-006229-7yoilsho	1755	21	,	,	,
cord-006229-7yoilsho	1755	22	we	-PRON-	PRP
cord-006229-7yoilsho	1755	23	anticipate	anticipate	VBP
cord-006229-7yoilsho	1755	24	FR	FR	NNP
cord-006229-7yoilsho	1755	25	to	to	TO
cord-006229-7yoilsho	1755	26	stand	stand	VB
cord-006229-7yoilsho	1755	27	out	out	RP
cord-006229-7yoilsho	1755	28	at	at	IN
cord-006229-7yoilsho	1755	29	least	least	JJS
cord-006229-7yoilsho	1755	30	equally	equally	RB
cord-006229-7yoilsho	1755	31	for	for	IN
cord-006229-7yoilsho	1755	32	investigations	investigation	NNS
cord-006229-7yoilsho	1755	33	into	into	IN
cord-006229-7yoilsho	1755	34	the	the	DT
cord-006229-7yoilsho	1755	35	biological	biological	JJ
cord-006229-7yoilsho	1755	36	relevance	relevance	NN
cord-006229-7yoilsho	1755	37	of	of	IN
cord-006229-7yoilsho	1755	38	Gq	Gq	NNP
cord-006229-7yoilsho	1755	39	.	.	.
cord-006229-7yoilsho	1756	1	Binary	binary	JJ
cord-006229-7yoilsho	1756	2	actin	actin	NN
cord-006229-7yoilsho	1756	3	ADP	ADP	NNP
cord-006229-7yoilsho	1756	4	-	-	HYPH
cord-006229-7yoilsho	1756	5	ribosylating	ribosylate	VBG
cord-006229-7yoilsho	1756	6	toxins	toxin	NNS
cord-006229-7yoilsho	1756	7	like	like	IN
cord-006229-7yoilsho	1756	8	C.	C.	NNP
cord-006229-7yoilsho	1756	9	perfringens	perfringens	NN
cord-006229-7yoilsho	1756	10	iota	iota	NN
cord-006229-7yoilsho	1756	11	toxin	toxin	NN
cord-006229-7yoilsho	1756	12	and	and	CC
cord-006229-7yoilsho	1756	13	C.	C.	NNP
cord-006229-7yoilsho	1756	14	difficile	difficile	NN
cord-006229-7yoilsho	1756	15	transferase	transferase	NN
cord-006229-7yoilsho	1756	16	CDT	CDT	NNP
cord-006229-7yoilsho	1756	17	cause	cause	VBP
cord-006229-7yoilsho	1756	18	depolymerisation	depolymerisation	NN
cord-006229-7yoilsho	1756	19	of	of	IN
cord-006229-7yoilsho	1756	20	the	the	DT
cord-006229-7yoilsho	1756	21	cortical	cortical	JJ
cord-006229-7yoilsho	1756	22	actin	actin	NN
cord-006229-7yoilsho	1756	23	cytoskeleton	cytoskeleton	NN
cord-006229-7yoilsho	1756	24	,	,	,
cord-006229-7yoilsho	1756	25	induce	induce	VB
cord-006229-7yoilsho	1756	26	the	the	DT
cord-006229-7yoilsho	1756	27	formation	formation	NN
cord-006229-7yoilsho	1756	28	of	of	IN
cord-006229-7yoilsho	1756	29	microtubule	microtubule	NN
cord-006229-7yoilsho	1756	30	-	-	HYPH
cord-006229-7yoilsho	1756	31	based	base	VBN
cord-006229-7yoilsho	1756	32	cell	cell	NN
cord-006229-7yoilsho	1756	33	membrane	membrane	NN
cord-006229-7yoilsho	1756	34	protrusions	protrusion	NNS
cord-006229-7yoilsho	1756	35	and	and	CC
cord-006229-7yoilsho	1756	36	redirect	redirect	VB
cord-006229-7yoilsho	1756	37	Rab	Rab	NNP
cord-006229-7yoilsho	1756	38	-	-	HYPH
cord-006229-7yoilsho	1756	39	dependent	dependent	JJ
cord-006229-7yoilsho	1756	40	intracellular	intracellular	JJ
cord-006229-7yoilsho	1756	41	traffic	traffic	NN
cord-006229-7yoilsho	1757	1	(	(	-LRB-
cord-006229-7yoilsho	1757	2	Schwan	Schwan	NNP
cord-006229-7yoilsho	1757	3	et	et	NNP
cord-006229-7yoilsho	1757	4	al	al	NNP
cord-006229-7yoilsho	1757	5	.	.	NNP
cord-006229-7yoilsho	1757	6	2009	2009	CD
cord-006229-7yoilsho	1757	7	)	)	-RRB-
cord-006229-7yoilsho	1757	8	.	.	.
cord-006229-7yoilsho	1758	1	Here	here	RB
cord-006229-7yoilsho	1758	2	,	,	,
cord-006229-7yoilsho	1758	3	we	-PRON-	PRP
cord-006229-7yoilsho	1758	4	employed	employ	VBD
cord-006229-7yoilsho	1758	5	the	the	DT
cord-006229-7yoilsho	1758	6	model	model	NN
cord-006229-7yoilsho	1758	7	of	of	IN
cord-006229-7yoilsho	1758	8	toxin	toxin	NN
cord-006229-7yoilsho	1758	9	-	-	HYPH
cord-006229-7yoilsho	1758	10	induced	induce	VBN
cord-006229-7yoilsho	1758	11	protrusions	protrusion	NNS
cord-006229-7yoilsho	1758	12	to	to	TO
cord-006229-7yoilsho	1758	13	study	study	VB
cord-006229-7yoilsho	1758	14	the	the	DT
cord-006229-7yoilsho	1758	15	formation	formation	NN
cord-006229-7yoilsho	1758	16	of	of	IN
cord-006229-7yoilsho	1758	17	cilia	cilium	NNS
cord-006229-7yoilsho	1758	18	.	.	.
cord-006229-7yoilsho	1759	1	We	-PRON-	PRP
cord-006229-7yoilsho	1759	2	found	find	VBD
cord-006229-7yoilsho	1759	3	that	that	DT
cord-006229-7yoilsho	1759	4	toxin	toxin	NN
cord-006229-7yoilsho	1759	5	-	-	HYPH
cord-006229-7yoilsho	1759	6	induced	induce	VBN
cord-006229-7yoilsho	1759	7	microtubule	microtubule	NN
cord-006229-7yoilsho	1759	8	-	-	HYPH
cord-006229-7yoilsho	1759	9	based	base	VBN
cord-006229-7yoilsho	1759	10	protrusion	protrusion	NN
cord-006229-7yoilsho	1759	11	formation	formation	NN
cord-006229-7yoilsho	1759	12	at	at	IN
cord-006229-7yoilsho	1759	13	the	the	DT
cord-006229-7yoilsho	1759	14	cell	cell	NN
cord-006229-7yoilsho	1759	15	membrane	membrane	NN
cord-006229-7yoilsho	1759	16	depends	depend	VBZ
cord-006229-7yoilsho	1759	17	on	on	IN
cord-006229-7yoilsho	1759	18	recruitment	recruitment	NN
cord-006229-7yoilsho	1759	19	of	of	IN
cord-006229-7yoilsho	1759	20	septins	septin	NNS
cord-006229-7yoilsho	1759	21	,	,	,
cord-006229-7yoilsho	1759	22	which	which	WDT
cord-006229-7yoilsho	1759	23	are	be	VBP
cord-006229-7yoilsho	1759	24	highly	highly	RB
cord-006229-7yoilsho	1759	25	conserved	conserve	VBN
cord-006229-7yoilsho	1759	26	,	,	,
cord-006229-7yoilsho	1759	27	small	small	JJ
cord-006229-7yoilsho	1759	28	GTPbinding	gtpbinding	NN
cord-006229-7yoilsho	1759	29	proteins	protein	NNS
cord-006229-7yoilsho	1759	30	.	.	.
cord-006229-7yoilsho	1760	1	Similar	similar	JJ
cord-006229-7yoilsho	1760	2	to	to	IN
cord-006229-7yoilsho	1760	3	toxin	toxin	NN
cord-006229-7yoilsho	1760	4	-	-	HYPH
cord-006229-7yoilsho	1760	5	caused	cause	VBN
cord-006229-7yoilsho	1760	6	protrusions	protrusion	NNS
cord-006229-7yoilsho	1760	7	,	,	,
cord-006229-7yoilsho	1760	8	septins	septin	NNS
cord-006229-7yoilsho	1760	9	are	be	VBP
cord-006229-7yoilsho	1760	10	also	also	RB
cord-006229-7yoilsho	1760	11	recruited	recruit	VBN
cord-006229-7yoilsho	1760	12	to	to	IN
cord-006229-7yoilsho	1760	13	the	the	DT
cord-006229-7yoilsho	1760	14	site	site	NN
cord-006229-7yoilsho	1760	15	of	of	IN
cord-006229-7yoilsho	1760	16	ciliogenesis	ciliogenesis	NNP
cord-006229-7yoilsho	1760	17	.	.	.
cord-006229-7yoilsho	1761	1	Inhibition	inhibition	NN
cord-006229-7yoilsho	1761	2	of	of	IN
cord-006229-7yoilsho	1761	3	septins	septin	NNS
cord-006229-7yoilsho	1761	4	by	by	IN
cord-006229-7yoilsho	1761	5	shRNA	shrna	RB
cord-006229-7yoilsho	1761	6	-	-	HYPH
cord-006229-7yoilsho	1761	7	based	base	VBN
cord-006229-7yoilsho	1761	8	knockdown	knockdown	NN
cord-006229-7yoilsho	1761	9	inhibits	inhibit	VBZ
cord-006229-7yoilsho	1761	10	ciliogenesis	ciliogenesis	NNP
cord-006229-7yoilsho	1761	11	as	as	IN
cord-006229-7yoilsho	1761	12	well	well	RB
cord-006229-7yoilsho	1761	13	toxin	toxin	NN
cord-006229-7yoilsho	1761	14	-	-	HYPH
cord-006229-7yoilsho	1761	15	induced	induce	VBN
cord-006229-7yoilsho	1761	16	protrusion	protrusion	NN
cord-006229-7yoilsho	1761	17	formation	formation	NN
cord-006229-7yoilsho	1761	18	.	.	.
cord-006229-7yoilsho	1762	1	Septins	septin	NNS
cord-006229-7yoilsho	1762	2	are	be	VBP
cord-006229-7yoilsho	1762	3	suggested	suggest	VBN
cord-006229-7yoilsho	1762	4	to	to	TO
cord-006229-7yoilsho	1762	5	be	be	VB
cord-006229-7yoilsho	1762	6	involved	involve	VBN
cord-006229-7yoilsho	1762	7	in	in	IN
cord-006229-7yoilsho	1762	8	exocytotic	exocytotic	JJ
cord-006229-7yoilsho	1762	9	processes	process	NNS
cord-006229-7yoilsho	1762	10	,	,	,
cord-006229-7yoilsho	1762	11	which	which	WDT
cord-006229-7yoilsho	1762	12	are	be	VBP
cord-006229-7yoilsho	1762	13	important	important	JJ
cord-006229-7yoilsho	1762	14	for	for	IN
cord-006229-7yoilsho	1762	15	ciliogenesis	ciliogenesis	NN
cord-006229-7yoilsho	1762	16	and	and	CC
cord-006229-7yoilsho	1762	17	also	also	RB
cord-006229-7yoilsho	1762	18	for	for	IN
cord-006229-7yoilsho	1762	19	toxin	toxin	NN
cord-006229-7yoilsho	1762	20	-	-	HYPH
cord-006229-7yoilsho	1762	21	induced	induce	VBN
cord-006229-7yoilsho	1762	22	protrusion	protrusion	NN
cord-006229-7yoilsho	1762	23	formation	formation	NN
cord-006229-7yoilsho	1762	24	.	.	.
cord-006229-7yoilsho	1763	1	Accordingly	accordingly	RB
cord-006229-7yoilsho	1763	2	,	,	,
cord-006229-7yoilsho	1763	3	translocation	translocation	NN
cord-006229-7yoilsho	1763	4	of	of	IN
cord-006229-7yoilsho	1763	5	septins	septin	NNS
cord-006229-7yoilsho	1763	6	is	be	VBZ
cord-006229-7yoilsho	1763	7	accompanied	accompany	VBN
cord-006229-7yoilsho	1763	8	by	by	IN
cord-006229-7yoilsho	1763	9	a	a	DT
cord-006229-7yoilsho	1763	10	recruitment	recruitment	NN
cord-006229-7yoilsho	1763	11	of	of	IN
cord-006229-7yoilsho	1763	12	Rab	Rab	NNP
cord-006229-7yoilsho	1763	13	proteins	protein	NNS
cord-006229-7yoilsho	1763	14	and	and	CC
cord-006229-7yoilsho	1763	15	proteins	protein	NNS
cord-006229-7yoilsho	1763	16	of	of	IN
cord-006229-7yoilsho	1763	17	the	the	DT
cord-006229-7yoilsho	1763	18	exocytotic	exocytotic	JJ
cord-006229-7yoilsho	1763	19	machinery	machinery	NN
cord-006229-7yoilsho	1763	20	.	.	.
cord-006229-7yoilsho	1764	1	The	the	DT
cord-006229-7yoilsho	1764	2	data	datum	NNS
cord-006229-7yoilsho	1764	3	indicate	indicate	VBP
cord-006229-7yoilsho	1764	4	that	that	IN
cord-006229-7yoilsho	1764	5	septins	septin	NNS
cord-006229-7yoilsho	1764	6	function	function	VB
cord-006229-7yoilsho	1764	7	as	as	IN
cord-006229-7yoilsho	1764	8	a	a	DT
cord-006229-7yoilsho	1764	9	scaffold	scaffold	NN
cord-006229-7yoilsho	1764	10	at	at	IN
cord-006229-7yoilsho	1764	11	the	the	DT
cord-006229-7yoilsho	1764	12	base	base	NN
cord-006229-7yoilsho	1764	13	of	of	IN
cord-006229-7yoilsho	1764	14	cellular	cellular	JJ
cord-006229-7yoilsho	1764	15	processes	process	NNS
cord-006229-7yoilsho	1764	16	like	like	IN
cord-006229-7yoilsho	1764	17	cilia	cilium	NNS
cord-006229-7yoilsho	1764	18	and	and	CC
cord-006229-7yoilsho	1764	19	toxin	toxin	NN
cord-006229-7yoilsho	1764	20	-	-	HYPH
cord-006229-7yoilsho	1764	21	induced	induce	VBN
cord-006229-7yoilsho	1764	22	protrusions	protrusion	NNS
cord-006229-7yoilsho	1764	23	,	,	,
cord-006229-7yoilsho	1764	24	organizing	organize	VBG
cord-006229-7yoilsho	1764	25	the	the	DT
cord-006229-7yoilsho	1764	26	cross	cross	NN
cord-006229-7yoilsho	1764	27	-	-	NN
cord-006229-7yoilsho	1764	28	talk	talk	NN
cord-006229-7yoilsho	1764	29	between	between	IN
cord-006229-7yoilsho	1764	30	the	the	DT
cord-006229-7yoilsho	1764	31	actin	actin	NN
cord-006229-7yoilsho	1764	32	cytoskeleton	cytoskeleton	NN
cord-006229-7yoilsho	1764	33	and	and	CC
cord-006229-7yoilsho	1764	34	microtubules	microtubule	VBZ
cord-006229-7yoilsho	1764	35	to	to	TO
cord-006229-7yoilsho	1764	36	regulate	regulate	VB
cord-006229-7yoilsho	1764	37	the	the	DT
cord-006229-7yoilsho	1764	38	vesicle	vesicle	NN
cord-006229-7yoilsho	1764	39	traffic	traffic	NN
cord-006229-7yoilsho	1764	40	-	-	HYPH
cord-006229-7yoilsho	1764	41	and	and	CC
cord-006229-7yoilsho	1764	42	exocytotic	exocytotic	JJ
cord-006229-7yoilsho	1764	43	machinery	machinery	NN
cord-006229-7yoilsho	1764	44	.	.	.
cord-006229-7yoilsho	1765	1	Hypervirulent	Hypervirulent	NNP
cord-006229-7yoilsho	1765	2	Clostridium	clostridium	NN
cord-006229-7yoilsho	1765	3	difficile	difficile	NN
cord-006229-7yoilsho	1765	4	strains	strain	NNS
cord-006229-7yoilsho	1765	5	are	be	VBP
cord-006229-7yoilsho	1765	6	associated	associate	VBN
cord-006229-7yoilsho	1765	7	with	with	IN
cord-006229-7yoilsho	1765	8	increased	increase	VBN
cord-006229-7yoilsho	1765	9	morbidity	morbidity	NN
cord-006229-7yoilsho	1765	10	and	and	CC
cord-006229-7yoilsho	1765	11	mortality	mortality	NN
cord-006229-7yoilsho	1765	12	.	.	.
cord-006229-7yoilsho	1766	1	These	these	DT
cord-006229-7yoilsho	1766	2	strains	strain	NNS
cord-006229-7yoilsho	1766	3	produce	produce	VBP
cord-006229-7yoilsho	1766	4	the	the	DT
cord-006229-7yoilsho	1766	5	actin	actin	JJ
cord-006229-7yoilsho	1766	6	-	-	HYPH
cord-006229-7yoilsho	1766	7	ADP	adp	NN
cord-006229-7yoilsho	1766	8	-	-	HYPH
cord-006229-7yoilsho	1766	9	ribosylating	ribosylate	VBG
cord-006229-7yoilsho	1766	10	Clostridium	clostridium	NN
cord-006229-7yoilsho	1766	11	difficile	difficile	NN
cord-006229-7yoilsho	1766	12	toxin	toxin	NN
cord-006229-7yoilsho	1766	13	CDT	CDT	NNP
cord-006229-7yoilsho	1766	14	.	.	.
cord-006229-7yoilsho	1767	1	CDT	CDT	NNP
cord-006229-7yoilsho	1767	2	depolymerizes	depolymerize	VBZ
cord-006229-7yoilsho	1767	3	the	the	DT
cord-006229-7yoilsho	1767	4	actin	actin	NN
cord-006229-7yoilsho	1767	5	cytoskeleton	cytoskeleton	NN
cord-006229-7yoilsho	1767	6	,	,	,
cord-006229-7yoilsho	1767	7	causes	cause	VBZ
cord-006229-7yoilsho	1767	8	formation	formation	NN
cord-006229-7yoilsho	1767	9	of	of	IN
cord-006229-7yoilsho	1767	10	microtubule	microtubule	NN
cord-006229-7yoilsho	1767	11	-	-	HYPH
cord-006229-7yoilsho	1767	12	based	base	VBN
cord-006229-7yoilsho	1767	13	protrusions	protrusion	NNS
cord-006229-7yoilsho	1767	14	and	and	CC
cord-006229-7yoilsho	1767	15	increases	increase	VBZ
cord-006229-7yoilsho	1767	16	pathogen	pathogen	NN
cord-006229-7yoilsho	1767	17	adherence	adherence	NN
cord-006229-7yoilsho	1767	18	.	.	.
cord-006229-7yoilsho	1768	1	Septins	septin	NNS
cord-006229-7yoilsho	1768	2	are	be	VBP
cord-006229-7yoilsho	1768	3	essential	essential	JJ
cord-006229-7yoilsho	1768	4	for	for	IN
cord-006229-7yoilsho	1768	5	CDT	CDT	NNP
cord-006229-7yoilsho	1768	6	-	-	HYPH
cord-006229-7yoilsho	1768	7	induced	induce	VBN
cord-006229-7yoilsho	1768	8	protrusion	protrusion	NN
cord-006229-7yoilsho	1768	9	formation	formation	NN
cord-006229-7yoilsho	1768	10	.	.	.
cord-006229-7yoilsho	1769	1	SEPT2	SEPT2	NNP
cord-006229-7yoilsho	1769	2	,	,	,
cord-006229-7yoilsho	1769	3	6	6	CD
cord-006229-7yoilsho	1769	4	,	,	,
cord-006229-7yoilsho	1769	5	and	and	CC
cord-006229-7yoilsho	1769	6	7	7	CD
cord-006229-7yoilsho	1769	7	accumulate	accumulate	VBP
cord-006229-7yoilsho	1769	8	at	at	IN
cord-006229-7yoilsho	1769	9	predetermined	predetermine	VBN
cord-006229-7yoilsho	1769	10	protrusion	protrusion	NN
cord-006229-7yoilsho	1769	11	sites	site	NNS
cord-006229-7yoilsho	1769	12	and	and	CC
cord-006229-7yoilsho	1769	13	form	form	VB
cord-006229-7yoilsho	1769	14	collar	collar	NN
cord-006229-7yoilsho	1769	15	-	-	HYPH
cord-006229-7yoilsho	1769	16	like	like	JJ
cord-006229-7yoilsho	1769	17	structures	structure	NNS
cord-006229-7yoilsho	1769	18	at	at	IN
cord-006229-7yoilsho	1769	19	the	the	DT
cord-006229-7yoilsho	1769	20	base	base	NN
cord-006229-7yoilsho	1769	21	of	of	IN
cord-006229-7yoilsho	1769	22	protrusions	protrusion	NNS
cord-006229-7yoilsho	1769	23	.	.	.
cord-006229-7yoilsho	1770	1	The	the	DT
cord-006229-7yoilsho	1770	2	septins	septin	NNS
cord-006229-7yoilsho	1770	3	are	be	VBP
cord-006229-7yoilsho	1770	4	a	a	DT
cord-006229-7yoilsho	1770	5	prerequisite	prerequisite	NN
cord-006229-7yoilsho	1770	6	for	for	IN
cord-006229-7yoilsho	1770	7	protrusion	protrusion	NN
cord-006229-7yoilsho	1770	8	formation	formation	NN
cord-006229-7yoilsho	1770	9	.	.	.
cord-006229-7yoilsho	1771	1	The	the	DT
cord-006229-7yoilsho	1771	2	inhibitor	inhibitor	NN
cord-006229-7yoilsho	1771	3	forchlorfenuron	forchlorfenuron	NN
cord-006229-7yoilsho	1771	4	or	or	CC
cord-006229-7yoilsho	1771	5	knock	knock	NN
cord-006229-7yoilsho	1771	6	-	-	HYPH
cord-006229-7yoilsho	1771	7	down	down	NN
cord-006229-7yoilsho	1771	8	of	of	IN
cord-006229-7yoilsho	1771	9	septins	septin	NNS
cord-006229-7yoilsho	1771	10	inhibit	inhibit	VB
cord-006229-7yoilsho	1771	11	protrusion	protrusion	NN
cord-006229-7yoilsho	1771	12	formation	formation	NN
cord-006229-7yoilsho	1771	13	.	.	.
cord-006229-7yoilsho	1772	1	Septins	septin	NNS
cord-006229-7yoilsho	1772	2	colocalize	colocalize	NN
cord-006229-7yoilsho	1772	3	with	with	IN
cord-006229-7yoilsho	1772	4	active	active	JJ
cord-006229-7yoilsho	1772	5	Cdc42	Cdc42	NNP
cord-006229-7yoilsho	1772	6	and	and	CC
cord-006229-7yoilsho	1772	7	its	-PRON-	PRP$
cord-006229-7yoilsho	1772	8	effector	effector	JJ
cord-006229-7yoilsho	1772	9	Borg	Borg	NNP
cord-006229-7yoilsho	1772	10	which	which	WDT
cord-006229-7yoilsho	1772	11	act	act	VBP
cord-006229-7yoilsho	1772	12	as	as	IN
cord-006229-7yoilsho	1772	13	up	up	IN
cord-006229-7yoilsho	1772	14	-	-	HYPH
cord-006229-7yoilsho	1772	15	stream	stream	NN
cord-006229-7yoilsho	1772	16	regulators	regulator	NNS
cord-006229-7yoilsho	1772	17	of	of	IN
cord-006229-7yoilsho	1772	18	septin	septin	JJ
cord-006229-7yoilsho	1772	19	polymerization	polymerization	NN
cord-006229-7yoilsho	1772	20	.	.	.
cord-006229-7yoilsho	1773	1	Microtubules	microtubule	NNS
cord-006229-7yoilsho	1773	2	interact	interact	VBP
cord-006229-7yoilsho	1773	3	with	with	IN
cord-006229-7yoilsho	1773	4	septin	septin	JJ
cord-006229-7yoilsho	1773	5	structures	structure	NNS
cord-006229-7yoilsho	1773	6	.	.	.
cord-006229-7yoilsho	1774	1	Precipitation	precipitation	NN
cord-006229-7yoilsho	1774	2	and	and	CC
cord-006229-7yoilsho	1774	3	surface	surface	NN
cord-006229-7yoilsho	1774	4	plasmon	plasmon	JJ
cord-006229-7yoilsho	1774	5	resonance	resonance	NN
cord-006229-7yoilsho	1774	6	studies	study	NNS
cord-006229-7yoilsho	1774	7	revealed	reveal	VBD
cord-006229-7yoilsho	1774	8	high	high	JJ
cord-006229-7yoilsho	1774	9	-	-	HYPH
cord-006229-7yoilsho	1774	10	affinity	affinity	NN
cord-006229-7yoilsho	1774	11	binding	binding	NN
cord-006229-7yoilsho	1774	12	of	of	IN
cord-006229-7yoilsho	1774	13	septins	septin	NNS
cord-006229-7yoilsho	1774	14	to	to	IN
cord-006229-7yoilsho	1774	15	microtubule	microtubule	NN
cord-006229-7yoilsho	1774	16	plus	plus	CC
cord-006229-7yoilsho	1774	17	end	end	NN
cord-006229-7yoilsho	1774	18	tracking	track	VBG
cord-006229-7yoilsho	1774	19	protein	protein	NN
cord-006229-7yoilsho	1774	20	EB1	EB1	NNP
cord-006229-7yoilsho	1774	21	thereby	thereby	RB
cord-006229-7yoilsho	1774	22	guiding	guide	VBG
cord-006229-7yoilsho	1774	23	incoming	incoming	JJ
cord-006229-7yoilsho	1774	24	microtubules	microtubule	NNS
cord-006229-7yoilsho	1774	25	.	.	.
cord-006229-7yoilsho	1775	1	The	the	DT
cord-006229-7yoilsho	1775	2	data	datum	NNS
cord-006229-7yoilsho	1775	3	indicate	indicate	VBP
cord-006229-7yoilsho	1775	4	that	that	IN
cord-006229-7yoilsho	1775	5	CDT	CDT	NNP
cord-006229-7yoilsho	1775	6	hijacks	hijack	VBZ
cord-006229-7yoilsho	1775	7	conserved	conserve	VBN
cord-006229-7yoilsho	1775	8	regulatory	regulatory	JJ
cord-006229-7yoilsho	1775	9	principles	principle	NNS
cord-006229-7yoilsho	1775	10	involved	involve	VBN
cord-006229-7yoilsho	1775	11	in	in	IN
cord-006229-7yoilsho	1775	12	microtubule	microtubule	NN
cord-006229-7yoilsho	1775	13	-	-	HYPH
cord-006229-7yoilsho	1775	14	membrane	membrane	NN
cord-006229-7yoilsho	1775	15	interaction	interaction	NN
cord-006229-7yoilsho	1775	16	,	,	,
cord-006229-7yoilsho	1775	17	depending	depend	VBG
cord-006229-7yoilsho	1775	18	on	on	IN
cord-006229-7yoilsho	1775	19	septins	septin	NNS
cord-006229-7yoilsho	1775	20	,	,	,
cord-006229-7yoilsho	1775	21	Cdc42	Cdc42	NNP
cord-006229-7yoilsho	1775	22	,	,	,
cord-006229-7yoilsho	1775	23	Borgs	Borgs	NNPS
cord-006229-7yoilsho	1775	24	and	and	CC
cord-006229-7yoilsho	1775	25	restructuring	restructuring	NN
cord-006229-7yoilsho	1775	26	of	of	IN
cord-006229-7yoilsho	1775	27	the	the	DT
cord-006229-7yoilsho	1775	28	actin	actin	NN
cord-006229-7yoilsho	1775	29	cytoskeleton	cytoskeleton	NN
cord-006229-7yoilsho	1775	30	.	.	.
cord-006229-7yoilsho	1776	1	The	the	DT
cord-006229-7yoilsho	1776	2	zebrafish	zebrafish	NN
cord-006229-7yoilsho	1776	3	Danio	Danio	NNP
cord-006229-7yoilsho	1776	4	rerio	rerio	NNP
cord-006229-7yoilsho	1776	5	has	have	VBZ
cord-006229-7yoilsho	1776	6	become	become	VBN
cord-006229-7yoilsho	1776	7	an	an	DT
cord-006229-7yoilsho	1776	8	important	important	JJ
cord-006229-7yoilsho	1776	9	vertebrate	vertebrate	JJ
cord-006229-7yoilsho	1776	10	model	model	NN
cord-006229-7yoilsho	1776	11	organism	organism	NN
cord-006229-7yoilsho	1776	12	for	for	IN
cord-006229-7yoilsho	1776	13	a	a	DT
cord-006229-7yoilsho	1776	14	wide	wide	JJ
cord-006229-7yoilsho	1776	15	range	range	NN
cord-006229-7yoilsho	1776	16	of	of	IN
cord-006229-7yoilsho	1776	17	scientific	scientific	JJ
cord-006229-7yoilsho	1776	18	questions	question	NNS
cord-006229-7yoilsho	1776	19	[	[	-LRB-
cord-006229-7yoilsho	1776	20	1	1	CD
cord-006229-7yoilsho	1776	21	]	]	-RRB-
cord-006229-7yoilsho	1776	22	.	.	.
cord-006229-7yoilsho	1777	1	Current	current	JJ
cord-006229-7yoilsho	1777	2	studies	study	NNS
cord-006229-7yoilsho	1777	3	are	be	VBP
cord-006229-7yoilsho	1777	4	mainly	mainly	RB
cord-006229-7yoilsho	1777	5	focused	focus	VBN
cord-006229-7yoilsho	1777	6	on	on	IN
cord-006229-7yoilsho	1777	7	development	development	NN
cord-006229-7yoilsho	1777	8	,	,	,
cord-006229-7yoilsho	1777	9	genetics	genetics	NN
cord-006229-7yoilsho	1777	10	and	and	CC
cord-006229-7yoilsho	1777	11	disease	disease	NN
cord-006229-7yoilsho	1777	12	for	for	IN
cord-006229-7yoilsho	1777	13	which	which	WDT
cord-006229-7yoilsho	1777	14	the	the	DT
cord-006229-7yoilsho	1777	15	zebrafish	zebrafish	NN
cord-006229-7yoilsho	1777	16	is	be	VBZ
cord-006229-7yoilsho	1777	17	particularly	particularly	RB
cord-006229-7yoilsho	1777	18	well	well	RB
cord-006229-7yoilsho	1777	19	suited	suited	JJ
cord-006229-7yoilsho	1777	20	due	due	IN
cord-006229-7yoilsho	1777	21	to	to	IN
cord-006229-7yoilsho	1777	22	its	-PRON-	PRP$
cord-006229-7yoilsho	1777	23	small	small	JJ
cord-006229-7yoilsho	1777	24	size	size	NN
cord-006229-7yoilsho	1777	25	,	,	,
cord-006229-7yoilsho	1777	26	rapid	rapid	JJ
cord-006229-7yoilsho	1777	27	development	development	NN
cord-006229-7yoilsho	1777	28	,	,	,
cord-006229-7yoilsho	1777	29	short	short	JJ
cord-006229-7yoilsho	1777	30	generation	generation	NN
cord-006229-7yoilsho	1777	31	time	time	NN
cord-006229-7yoilsho	1777	32	,	,	,
cord-006229-7yoilsho	1777	33	optical	optical	JJ
cord-006229-7yoilsho	1777	34	transparency	transparency	NN
cord-006229-7yoilsho	1777	35	of	of	IN
cord-006229-7yoilsho	1777	36	embryos	embryo	NNS
cord-006229-7yoilsho	1777	37	and	and	CC
cord-006229-7yoilsho	1777	38	larvae	larva	NNS
cord-006229-7yoilsho	1777	39	as	as	RB
cord-006229-7yoilsho	1777	40	well	well	RB
cord-006229-7yoilsho	1777	41	as	as	IN
cord-006229-7yoilsho	1777	42	conservation	conservation	NN
cord-006229-7yoilsho	1777	43	in	in	IN
cord-006229-7yoilsho	1777	44	functional	functional	JJ
cord-006229-7yoilsho	1777	45	domains	domain	NNS
cord-006229-7yoilsho	1777	46	[	[	-LRB-
cord-006229-7yoilsho	1777	47	1	1	CD
cord-006229-7yoilsho	1777	48	]	]	-RRB-
cord-006229-7yoilsho	1777	49	.	.	.
cord-006229-7yoilsho	1778	1	Hitherto	hitherto	RB
cord-006229-7yoilsho	1778	2	,	,	,
cord-006229-7yoilsho	1778	3	nothing	nothing	NN
cord-006229-7yoilsho	1778	4	is	be	VBZ
cord-006229-7yoilsho	1778	5	known	know	VBN
cord-006229-7yoilsho	1778	6	about	about	IN
cord-006229-7yoilsho	1778	7	the	the	DT
cord-006229-7yoilsho	1778	8	composition	composition	NN
cord-006229-7yoilsho	1778	9	and	and	CC
cord-006229-7yoilsho	1778	10	endogenous	endogenous	JJ
cord-006229-7yoilsho	1778	11	level	level	NN
cord-006229-7yoilsho	1778	12	of	of	IN
cord-006229-7yoilsho	1778	13	different	different	JJ
cord-006229-7yoilsho	1778	14	cNMPs	cnmp	NNS
cord-006229-7yoilsho	1778	15	in	in	IN
cord-006229-7yoilsho	1778	16	various	various	JJ
cord-006229-7yoilsho	1778	17	developmental	developmental	JJ
cord-006229-7yoilsho	1778	18	stages	stage	NNS
cord-006229-7yoilsho	1778	19	and	and	CC
cord-006229-7yoilsho	1778	20	organs	organ	NNS
cord-006229-7yoilsho	1778	21	of	of	IN
cord-006229-7yoilsho	1778	22	Danio	Danio	NNP
cord-006229-7yoilsho	1778	23	rerio	rerio	NN
cord-006229-7yoilsho	1778	24	.	.	.
cord-006229-7yoilsho	1779	1	Therefore	therefore	RB
cord-006229-7yoilsho	1779	2	,	,	,
cord-006229-7yoilsho	1779	3	we	-PRON-	PRP
cord-006229-7yoilsho	1779	4	used	use	VBD
cord-006229-7yoilsho	1779	5	the	the	DT
cord-006229-7yoilsho	1779	6	zebrafish	zebrafish	NN
cord-006229-7yoilsho	1779	7	in	in	IN
cord-006229-7yoilsho	1779	8	our	-PRON-	PRP$
cord-006229-7yoilsho	1779	9	study	study	NN
cord-006229-7yoilsho	1779	10	as	as	IN
cord-006229-7yoilsho	1779	11	a	a	DT
cord-006229-7yoilsho	1779	12	vertebrate	vertebrate	JJ
cord-006229-7yoilsho	1779	13	model	model	NN
cord-006229-7yoilsho	1779	14	to	to	TO
cord-006229-7yoilsho	1779	15	characterize	characterize	VB
cord-006229-7yoilsho	1779	16	systematically	systematically	RB
cord-006229-7yoilsho	1779	17	the	the	DT
cord-006229-7yoilsho	1779	18	temporal	temporal	JJ
cord-006229-7yoilsho	1779	19	-	-	HYPH
cord-006229-7yoilsho	1779	20	and	and	CC
cord-006229-7yoilsho	1779	21	organspecific	organspecific	JJ
cord-006229-7yoilsho	1779	22	occurrence(s	occurrence(s	NNP
cord-006229-7yoilsho	1779	23	)	)	-RRB-
cord-006229-7yoilsho	1779	24	of	of	IN
cord-006229-7yoilsho	1779	25	all	all	DT
cord-006229-7yoilsho	1779	26	cNMPs	cNMPs	NNP
cord-006229-7yoilsho	1779	27	including	include	VBG
cord-006229-7yoilsho	1779	28	cUMP	cUMP	NNP
cord-006229-7yoilsho	1779	29	in	in	IN
cord-006229-7yoilsho	1779	30	vivo	vivo	NNP
cord-006229-7yoilsho	1779	31	.	.	.
cord-006229-7yoilsho	1780	1	Cyclic	cyclic	JJ
cord-006229-7yoilsho	1780	2	nucleotides	nucleotide	NNS
cord-006229-7yoilsho	1780	3	were	be	VBD
cord-006229-7yoilsho	1780	4	quantified	quantify	VBN
cord-006229-7yoilsho	1780	5	by	by	IN
cord-006229-7yoilsho	1780	6	high	high	JJ
cord-006229-7yoilsho	1780	7	performance	performance	NN
cord-006229-7yoilsho	1780	8	liquid	liquid	NN
cord-006229-7yoilsho	1780	9	chromatography	chromatography	NN
cord-006229-7yoilsho	1780	10	quadrupole	quadrupole	NN
cord-006229-7yoilsho	1780	11	tandem	tandem	NN
cord-006229-7yoilsho	1780	12	mass	mass	NN
cord-006229-7yoilsho	1780	13	spectrometry	spectrometry	NN
cord-006229-7yoilsho	1780	14	.	.	.
cord-006229-7yoilsho	1781	1	We	-PRON-	PRP
cord-006229-7yoilsho	1781	2	observed	observe	VBD
cord-006229-7yoilsho	1781	3	specific	specific	JJ
cord-006229-7yoilsho	1781	4	cNMP	cnmp	NN
cord-006229-7yoilsho	1781	5	patterns	pattern	NNS
cord-006229-7yoilsho	1781	6	in	in	IN
cord-006229-7yoilsho	1781	7	developmental	developmental	JJ
cord-006229-7yoilsho	1781	8	stages	stage	NNS
cord-006229-7yoilsho	1781	9	and	and	CC
cord-006229-7yoilsho	1781	10	different	different	JJ
cord-006229-7yoilsho	1781	11	organs	organ	NNS
cord-006229-7yoilsho	1781	12	from	from	IN
cord-006229-7yoilsho	1781	13	adult	adult	NN
cord-006229-7yoilsho	1781	14	zebrafish	zebrafish	NN
cord-006229-7yoilsho	1781	15	,	,	,
cord-006229-7yoilsho	1781	16	which	which	WDT
cord-006229-7yoilsho	1781	17	is	be	VBZ
cord-006229-7yoilsho	1781	18	in	in	IN
cord-006229-7yoilsho	1781	19	support	support	NN
cord-006229-7yoilsho	1781	20	of	of	IN
cord-006229-7yoilsho	1781	21	the	the	DT
cord-006229-7yoilsho	1781	22	hypothesis	hypothesis	NN
cord-006229-7yoilsho	1781	23	of	of	IN
cord-006229-7yoilsho	1781	24	a	a	DT
cord-006229-7yoilsho	1781	25	distinct	distinct	JJ
cord-006229-7yoilsho	1781	26	cNMP	cnmp	NN
cord-006229-7yoilsho	1781	27	signaling	signal	VBG
cord-006229-7yoilsho	1781	28	code	code	NN
cord-006229-7yoilsho	1781	29	[	[	-LRB-
cord-006229-7yoilsho	1781	30	2	2	CD
cord-006229-7yoilsho	1781	31	]	]	-RRB-
cord-006229-7yoilsho	1781	32	.	.	.
cord-006229-7yoilsho	1782	1	cAMP	camp	NN
cord-006229-7yoilsho	1782	2	,	,	,
cord-006229-7yoilsho	1782	3	cGMP	cGMP	NNP
cord-006229-7yoilsho	1782	4	and	and	CC
cord-006229-7yoilsho	1782	5	cUMP	cUMP	NNP
cord-006229-7yoilsho	1782	6	were	be	VBD
cord-006229-7yoilsho	1782	7	present	present	JJ
cord-006229-7yoilsho	1782	8	in	in	IN
cord-006229-7yoilsho	1782	9	tissue	tissue	NN
cord-006229-7yoilsho	1782	10	samples	sample	NNS
cord-006229-7yoilsho	1782	11	of	of	IN
cord-006229-7yoilsho	1782	12	both	both	DT
cord-006229-7yoilsho	1782	13	developmental	developmental	JJ
cord-006229-7yoilsho	1782	14	stages	stage	NNS
cord-006229-7yoilsho	1783	1	(	(	-LRB-
cord-006229-7yoilsho	1783	2	embryos	embryo	NNS
cord-006229-7yoilsho	1783	3	at	at	IN
cord-006229-7yoilsho	1783	4	24	24	CD
cord-006229-7yoilsho	1783	5	hours	hour	NNS
cord-006229-7yoilsho	1783	6	post	post	NN
cord-006229-7yoilsho	1783	7	fertilization	fertilization	NN
cord-006229-7yoilsho	1783	8	,	,	,
cord-006229-7yoilsho	1783	9	larvae	larva	NNS
cord-006229-7yoilsho	1783	10	at	at	IN
cord-006229-7yoilsho	1783	11	5	5	CD
cord-006229-7yoilsho	1783	12	days	day	NNS
cord-006229-7yoilsho	1783	13	post	post	NN
cord-006229-7yoilsho	1783	14	fertilization	fertilization	NN
cord-006229-7yoilsho	1783	15	)	)	-RRB-
cord-006229-7yoilsho	1783	16	and	and	CC
cord-006229-7yoilsho	1783	17	within	within	IN
cord-006229-7yoilsho	1783	18	all	all	DT
cord-006229-7yoilsho	1783	19	harvested	harvest	VBN
cord-006229-7yoilsho	1783	20	organs	organ	NNS
cord-006229-7yoilsho	1783	21	.	.	.
cord-006229-7yoilsho	1784	1	Remarkably	remarkably	RB
cord-006229-7yoilsho	1784	2	,	,	,
cord-006229-7yoilsho	1784	3	these	these	DT
cord-006229-7yoilsho	1784	4	three	three	CD
cord-006229-7yoilsho	1784	5	cNMPs	cNMPs	NNPS
cord-006229-7yoilsho	1784	6	were	be	VBD
cord-006229-7yoilsho	1784	7	the	the	DT
cord-006229-7yoilsho	1784	8	only	only	JJ
cord-006229-7yoilsho	1784	9	ones	one	NNS
cord-006229-7yoilsho	1784	10	detected	detect	VBN
cord-006229-7yoilsho	1784	11	in	in	IN
cord-006229-7yoilsho	1784	12	the	the	DT
cord-006229-7yoilsho	1784	13	brain	brain	NN
cord-006229-7yoilsho	1784	14	.	.	.
cord-006229-7yoilsho	1785	1	cAMP	camp	NN
cord-006229-7yoilsho	1785	2	concentration	concentration	NN
cord-006229-7yoilsho	1785	3	of	of	IN
cord-006229-7yoilsho	1785	4	entrails	entrail	NNS
cord-006229-7yoilsho	1785	5	as	as	RB
cord-006229-7yoilsho	1785	6	well	well	RB
cord-006229-7yoilsho	1785	7	as	as	IN
cord-006229-7yoilsho	1785	8	cAMP	camp	NN
cord-006229-7yoilsho	1785	9	and	and	CC
cord-006229-7yoilsho	1785	10	cGMP	cGMP	NNP
cord-006229-7yoilsho	1785	11	concentrations	concentration	NNS
cord-006229-7yoilsho	1785	12	in	in	IN
cord-006229-7yoilsho	1785	13	the	the	DT
cord-006229-7yoilsho	1785	14	brain	brain	NN
cord-006229-7yoilsho	1785	15	were	be	VBD
cord-006229-7yoilsho	1785	16	similar	similar	JJ
cord-006229-7yoilsho	1785	17	to	to	IN
cord-006229-7yoilsho	1785	18	those	those	DT
cord-006229-7yoilsho	1785	19	previously	previously	RB
cord-006229-7yoilsho	1785	20	described	describe	VBN
cord-006229-7yoilsho	1785	21	in	in	IN
cord-006229-7yoilsho	1785	22	mouse	mouse	NN
cord-006229-7yoilsho	1785	23	tissues	tissue	NNS
cord-006229-7yoilsho	1785	24	[	[	-LRB-
cord-006229-7yoilsho	1785	25	3	3	CD
cord-006229-7yoilsho	1785	26	]	]	-RRB-
cord-006229-7yoilsho	1785	27	.	.	.
cord-006229-7yoilsho	1786	1	cCMP	cCMP	NNP
cord-006229-7yoilsho	1786	2	was	be	VBD
cord-006229-7yoilsho	1786	3	detected	detect	VBN
cord-006229-7yoilsho	1786	4	throughout	throughout	IN
cord-006229-7yoilsho	1786	5	development	development	NN
cord-006229-7yoilsho	1786	6	and	and	CC
cord-006229-7yoilsho	1786	7	was	be	VBD
cord-006229-7yoilsho	1786	8	present	present	JJ
cord-006229-7yoilsho	1786	9	in	in	IN
cord-006229-7yoilsho	1786	10	all	all	DT
cord-006229-7yoilsho	1786	11	organs	organ	NNS
cord-006229-7yoilsho	1786	12	except	except	IN
cord-006229-7yoilsho	1786	13	the	the	DT
cord-006229-7yoilsho	1786	14	brain	brain	NN
cord-006229-7yoilsho	1786	15	.	.	.
cord-006229-7yoilsho	1787	1	The	the	DT
cord-006229-7yoilsho	1787	2	identity	identity	NN
cord-006229-7yoilsho	1787	3	of	of	IN
cord-006229-7yoilsho	1787	4	cCMP	ccmp	NN
cord-006229-7yoilsho	1787	5	and	and	CC
cord-006229-7yoilsho	1787	6	cUMP	cump	NN
cord-006229-7yoilsho	1787	7	in	in	IN
cord-006229-7yoilsho	1787	8	the	the	DT
cord-006229-7yoilsho	1787	9	zebrafish	zebrafish	NN
cord-006229-7yoilsho	1787	10	was	be	VBD
cord-006229-7yoilsho	1787	11	confirmed	confirm	VBN
cord-006229-7yoilsho	1787	12	by	by	IN
cord-006229-7yoilsho	1787	13	high	high	JJ
cord-006229-7yoilsho	1787	14	performance	performance	NN
cord-006229-7yoilsho	1787	15	liquid	liquid	NN
cord-006229-7yoilsho	1787	16	chromatography	chromatography	NN
cord-006229-7yoilsho	1787	17	quadrupole	quadrupole	NN
cord-006229-7yoilsho	1787	18	time	time	NN
cord-006229-7yoilsho	1787	19	-	-	HYPH
cord-006229-7yoilsho	1787	20	of	of	IN
cord-006229-7yoilsho	1787	21	-	-	HYPH
cord-006229-7yoilsho	1787	22	flight	flight	NN
cord-006229-7yoilsho	1787	23	mass	mass	NN
cord-006229-7yoilsho	1787	24	spectrometry	spectrometry	NN
cord-006229-7yoilsho	1787	25	(	(	-LRB-
cord-006229-7yoilsho	1787	26	HPLC	HPLC	NNP
cord-006229-7yoilsho	1787	27	-	-	HYPH
cord-006229-7yoilsho	1787	28	MS	MS	NNP
cord-006229-7yoilsho	1787	29	/	/	SYM
cord-006229-7yoilsho	1787	30	TOF	TOF	NNP
cord-006229-7yoilsho	1787	31	)	)	-RRB-
cord-006229-7yoilsho	1787	32	.	.	.
cord-006229-7yoilsho	1788	1	Thus	thus	RB
cord-006229-7yoilsho	1788	2	,	,	,
cord-006229-7yoilsho	1788	3	we	-PRON-	PRP
cord-006229-7yoilsho	1788	4	unequivocally	unequivocally	RB
cord-006229-7yoilsho	1788	5	show	show	VBP
cord-006229-7yoilsho	1788	6	for	for	IN
cord-006229-7yoilsho	1788	7	the	the	DT
cord-006229-7yoilsho	1788	8	first	first	JJ
cord-006229-7yoilsho	1788	9	time	time	NN
cord-006229-7yoilsho	1788	10	that	that	WDT
cord-006229-7yoilsho	1788	11	cUMP	cump	NN
cord-006229-7yoilsho	1788	12	occurs	occur	VBZ
cord-006229-7yoilsho	1788	13	in	in	IN
cord-006229-7yoilsho	1788	14	vertebrates	vertebrate	NNS
cord-006229-7yoilsho	1788	15	.	.	.
cord-006229-7yoilsho	1789	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	1789	2	,	,	,
cord-006229-7yoilsho	1789	3	we	-PRON-	PRP
cord-006229-7yoilsho	1789	4	detected	detect	VBD
cord-006229-7yoilsho	1789	5	cIMP	cimp	CC
cord-006229-7yoilsho	1789	6	in	in	IN
cord-006229-7yoilsho	1789	7	several	several	JJ
cord-006229-7yoilsho	1789	8	developmental	developmental	JJ
cord-006229-7yoilsho	1789	9	stages	stage	NNS
cord-006229-7yoilsho	1789	10	of	of	IN
cord-006229-7yoilsho	1789	11	the	the	DT
cord-006229-7yoilsho	1789	12	zebrafish	zebrafish	NN
cord-006229-7yoilsho	1789	13	,	,	,
cord-006229-7yoilsho	1789	14	and	and	CC
cord-006229-7yoilsho	1789	15	observed	observe	VBD
cord-006229-7yoilsho	1789	16	the	the	DT
cord-006229-7yoilsho	1789	17	highest	high	JJS
cord-006229-7yoilsho	1789	18	concentrations	concentration	NNS
cord-006229-7yoilsho	1789	19	in	in	IN
cord-006229-7yoilsho	1789	20	testes	testis	NNS
cord-006229-7yoilsho	1789	21	and	and	CC
cord-006229-7yoilsho	1789	22	heart	heart	NN
cord-006229-7yoilsho	1789	23	,	,	,
cord-006229-7yoilsho	1789	24	but	but	CC
cord-006229-7yoilsho	1789	25	we	-PRON-	PRP
cord-006229-7yoilsho	1789	26	were	be	VBD
cord-006229-7yoilsho	1789	27	unable	unable	JJ
cord-006229-7yoilsho	1789	28	to	to	TO
cord-006229-7yoilsho	1789	29	unequivocally	unequivocally	RB
cord-006229-7yoilsho	1789	30	identify	identify	VB
cord-006229-7yoilsho	1789	31	cIMP	cimp	JJ
cord-006229-7yoilsho	1789	32	via	via	IN
cord-006229-7yoilsho	1789	33	HPLC	HPLC	NNP
cord-006229-7yoilsho	1789	34	-	-	HYPH
cord-006229-7yoilsho	1789	35	MS	MS	NNP
cord-006229-7yoilsho	1789	36	/	/	SYM
cord-006229-7yoilsho	1789	37	TOF	TOF	NNP
cord-006229-7yoilsho	1789	38	.	.	.
cord-006229-7yoilsho	1790	1	In	in	IN
cord-006229-7yoilsho	1790	2	the	the	DT
cord-006229-7yoilsho	1790	3	zebrafish	zebrafish	NN
cord-006229-7yoilsho	1790	4	,	,	,
cord-006229-7yoilsho	1790	5	sAC	sAC	NNP
cord-006229-7yoilsho	1790	6	is	be	VBZ
cord-006229-7yoilsho	1790	7	evolutionarily	evolutionarily	RB
cord-006229-7yoilsho	1790	8	not	not	RB
cord-006229-7yoilsho	1790	9	conserved	conserve	VBN
cord-006229-7yoilsho	1790	10	and	and	CC
cord-006229-7yoilsho	1790	11	absent	absent	JJ
cord-006229-7yoilsho	1790	12	,	,	,
cord-006229-7yoilsho	1790	13	since	since	IN
cord-006229-7yoilsho	1790	14	a	a	DT
cord-006229-7yoilsho	1790	15	search	search	NN
cord-006229-7yoilsho	1790	16	in	in	IN
cord-006229-7yoilsho	1790	17	the	the	DT
cord-006229-7yoilsho	1790	18	NCBI	NCBI	NNP
cord-006229-7yoilsho	1790	19	gene	gene	NN
cord-006229-7yoilsho	1790	20	data	datum	NNS
cord-006229-7yoilsho	1790	21	base	base	NN
cord-006229-7yoilsho	1790	22	revealed	reveal	VBD
cord-006229-7yoilsho	1790	23	no	no	DT
cord-006229-7yoilsho	1790	24	entry	entry	NN
cord-006229-7yoilsho	1790	25	for	for	IN
cord-006229-7yoilsho	1790	26	sAC	sAC	NNP
cord-006229-7yoilsho	1790	27	(	(	-LRB-
cord-006229-7yoilsho	1790	28	also	also	RB
cord-006229-7yoilsho	1790	29	referred	refer	VBN
cord-006229-7yoilsho	1790	30	to	to	IN
cord-006229-7yoilsho	1790	31	as	as	IN
cord-006229-7yoilsho	1790	32	AC10	AC10	NNP
cord-006229-7yoilsho	1790	33	)	)	-RRB-
cord-006229-7yoilsho	1790	34	.	.	.
cord-006229-7yoilsho	1791	1	Therefore	therefore	RB
cord-006229-7yoilsho	1791	2	,	,	,
cord-006229-7yoilsho	1791	3	sAC	sac	FW
cord-006229-7yoilsho	1791	4	can	can	MD
cord-006229-7yoilsho	1791	5	be	be	VB
cord-006229-7yoilsho	1791	6	excluded	exclude	VBN
cord-006229-7yoilsho	1791	7	as	as	IN
cord-006229-7yoilsho	1791	8	cUMP	cump	NN
cord-006229-7yoilsho	1791	9	-	-	HYPH
cord-006229-7yoilsho	1791	10	and	and	CC
cord-006229-7yoilsho	1791	11	cCMP	ccmp	NN
cord-006229-7yoilsho	1791	12	generator	generator	NN
cord-006229-7yoilsho	1791	13	in	in	IN
cord-006229-7yoilsho	1791	14	this	this	DT
cord-006229-7yoilsho	1791	15	system	system	NN
cord-006229-7yoilsho	1791	16	and	and	CC
cord-006229-7yoilsho	1791	17	sGC	sGC	NNS
cord-006229-7yoilsho	1791	18	remains	remain	VBZ
cord-006229-7yoilsho	1791	19	as	as	IN
cord-006229-7yoilsho	1791	20	the	the	DT
cord-006229-7yoilsho	1791	21	only	only	JJ
cord-006229-7yoilsho	1791	22	bona	bona	JJ
cord-006229-7yoilsho	1791	23	fide	fide	FW
cord-006229-7yoilsho	1791	24	cUMP	cump	NN
cord-006229-7yoilsho	1791	25	-	-	HYPH
cord-006229-7yoilsho	1791	26	and	and	CC
cord-006229-7yoilsho	1791	27	cCMP	ccmp	NN
cord-006229-7yoilsho	1791	28	generator	generator	NN
cord-006229-7yoilsho	1791	29	in	in	IN
cord-006229-7yoilsho	1791	30	the	the	DT
cord-006229-7yoilsho	1791	31	zebrafish	zebrafish	NN
cord-006229-7yoilsho	1791	32	.	.	.
cord-006229-7yoilsho	1792	1	To	to	TO
cord-006229-7yoilsho	1792	2	test	test	VB
cord-006229-7yoilsho	1792	3	this	this	DT
cord-006229-7yoilsho	1792	4	hypothesis	hypothesis	NN
cord-006229-7yoilsho	1792	5	,	,	,
cord-006229-7yoilsho	1792	6	the	the	DT
cord-006229-7yoilsho	1792	7	effects	effect	NNS
cord-006229-7yoilsho	1792	8	of	of	IN
cord-006229-7yoilsho	1792	9	NO	no	DT
cord-006229-7yoilsho	1792	10	donors	donor	NNS
cord-006229-7yoilsho	1792	11	,	,	,
cord-006229-7yoilsho	1792	12	sGC	sGC	NNP
cord-006229-7yoilsho	1792	13	stimulators	stimulator	NNS
cord-006229-7yoilsho	1792	14	and	and	CC
cord-006229-7yoilsho	1792	15	sGC	sGC	NNP
cord-006229-7yoilsho	1792	16	activators	activator	NNS
cord-006229-7yoilsho	1792	17	on	on	IN
cord-006229-7yoilsho	1792	18	cUMP	cump	NN
cord-006229-7yoilsho	1792	19	levels	level	NNS
cord-006229-7yoilsho	1792	20	in	in	IN
cord-006229-7yoilsho	1792	21	zebrafish	zebrafish	NN
cord-006229-7yoilsho	1792	22	should	should	MD
cord-006229-7yoilsho	1792	23	be	be	VB
cord-006229-7yoilsho	1792	24	examined	examine	VBN
cord-006229-7yoilsho	1792	25	in	in	IN
cord-006229-7yoilsho	1792	26	future	future	JJ
cord-006229-7yoilsho	1792	27	studies	study	NNS
cord-006229-7yoilsho	1792	28	.	.	.
cord-006229-7yoilsho	1793	1	Recently	recently	RB
cord-006229-7yoilsho	1793	2	,	,	,
cord-006229-7yoilsho	1793	3	induction	induction	NN
cord-006229-7yoilsho	1793	4	of	of	IN
cord-006229-7yoilsho	1793	5	apoptosis	apoptosis	NN
cord-006229-7yoilsho	1793	6	in	in	IN
cord-006229-7yoilsho	1793	7	mouse	mouse	NN
cord-006229-7yoilsho	1793	8	lymphoma	lymphoma	NN
cord-006229-7yoilsho	1793	9	cells	cell	NNS
cord-006229-7yoilsho	1793	10	by	by	IN
cord-006229-7yoilsho	1793	11	cCMP	ccmp	NN
cord-006229-7yoilsho	1793	12	-	-	:
cord-006229-7yoilsho	1793	13	AM	AM	NNP
cord-006229-7yoilsho	1793	14	has	have	VBZ
cord-006229-7yoilsho	1793	15	been	be	VBN
cord-006229-7yoilsho	1793	16	described	describe	VBN
cord-006229-7yoilsho	1793	17	[	[	-LRB-
cord-006229-7yoilsho	1793	18	4	4	CD
cord-006229-7yoilsho	1793	19	]	]	-RRB-
cord-006229-7yoilsho	1793	20	.	.	.
cord-006229-7yoilsho	1794	1	Thus	thus	RB
cord-006229-7yoilsho	1794	2	,	,	,
cord-006229-7yoilsho	1794	3	it	-PRON-	PRP
cord-006229-7yoilsho	1794	4	would	would	MD
cord-006229-7yoilsho	1794	5	be	be	VB
cord-006229-7yoilsho	1794	6	interesting	interesting	JJ
cord-006229-7yoilsho	1794	7	to	to	TO
cord-006229-7yoilsho	1794	8	examine	examine	VB
cord-006229-7yoilsho	1794	9	the	the	DT
cord-006229-7yoilsho	1794	10	effect	effect	NN
cord-006229-7yoilsho	1794	11	of	of	IN
cord-006229-7yoilsho	1794	12	cCMP	ccmp	NN
cord-006229-7yoilsho	1794	13	-	-	:
cord-006229-7yoilsho	1794	14	AM	am	NN
cord-006229-7yoilsho	1794	15	on	on	IN
cord-006229-7yoilsho	1794	16	zebrafish	zebrafish	NN
cord-006229-7yoilsho	1794	17	embryos	embryo	NNS
cord-006229-7yoilsho	1794	18	in	in	IN
cord-006229-7yoilsho	1794	19	future	future	JJ
cord-006229-7yoilsho	1794	20	studies	study	NNS
cord-006229-7yoilsho	1794	21	as	as	RB
cord-006229-7yoilsho	1794	22	well	well	RB
cord-006229-7yoilsho	1794	23	.	.	.
cord-006229-7yoilsho	1795	1	[	[	-LRB-
cord-006229-7yoilsho	1795	2	1	1	CD
cord-006229-7yoilsho	1795	3	]	]	-RRB-
cord-006229-7yoilsho	1795	4	Seifert	Seifert	NNP
cord-006229-7yoilsho	1795	5	,	,	,
cord-006229-7yoilsho	1795	6	R.	R.	NNP
cord-006229-7yoilsho	1795	7	:	:	:
cord-006229-7yoilsho	1795	8	cCMP	cCMP	NNP
cord-006229-7yoilsho	1796	1	and	and	CC
cord-006229-7yoilsho	1796	2	cUMP	cUMP	NNP
cord-006229-7yoilsho	1796	3	:	:	:
cord-006229-7yoilsho	1796	4	emerging	emerge	VBG
cord-006229-7yoilsho	1796	5	second	second	JJ
cord-006229-7yoilsho	1796	6	messengers	messenger	NNS
cord-006229-7yoilsho	1796	7	,	,	,
cord-006229-7yoilsho	1796	8	Trends	Trends	NNPS
cord-006229-7yoilsho	1796	9	in	in	IN
cord-006229-7yoilsho	1796	10	Biochemical	Biochemical	NNP
cord-006229-7yoilsho	1796	11	Sciences	Sciences	NNPS
cord-006229-7yoilsho	1796	12	40	40	CD
cord-006229-7yoilsho	1796	13	,	,	,
cord-006229-7yoilsho	1796	14	8	8	CD
cord-006229-7yoilsho	1796	15	-	-	SYM
cord-006229-7yoilsho	1796	16	15	15	CD
cord-006229-7yoilsho	1796	17	(	(	-LRB-
cord-006229-7yoilsho	1796	18	2015	2015	CD
cord-006229-7yoilsho	1796	19	)	)	-RRB-
cord-006229-7yoilsho	1796	20	.	.	.
cord-006229-7yoilsho	1797	1	cCMP	cCMP	NNP
cord-006229-7yoilsho	1797	2	,	,	,
cord-006229-7yoilsho	1798	1	3',5'-cUMP	3',5'-cump	CD
cord-006229-7yoilsho	1798	2	and	and	CC
cord-006229-7yoilsho	1798	3	3',5'-cIMP	3',5'-cimp	CD
cord-006229-7yoilsho	1798	4	were	be	VBD
cord-006229-7yoilsho	1798	5	ineffective	ineffective	JJ
cord-006229-7yoilsho	1798	6	.	.	.
cord-006229-7yoilsho	1799	1	To	to	TO
cord-006229-7yoilsho	1799	2	further	further	RB
cord-006229-7yoilsho	1799	3	characterize	characterize	VB
cord-006229-7yoilsho	1799	4	the	the	DT
cord-006229-7yoilsho	1799	5	action	action	NN
cord-006229-7yoilsho	1799	6	of	of	IN
cord-006229-7yoilsho	1799	7	3',5'-cGMP	3',5'-cgmp	CD
cord-006229-7yoilsho	1799	8	on	on	IN
cord-006229-7yoilsho	1799	9	HuT-78	HuT-78	NNP
cord-006229-7yoilsho	1799	10	cells	cell	NNS
cord-006229-7yoilsho	1799	11	,	,	,
cord-006229-7yoilsho	1799	12	we	-PRON-	PRP
cord-006229-7yoilsho	1799	13	determined	determine	VBD
cord-006229-7yoilsho	1799	14	apoptosis	apoptosis	NN
cord-006229-7yoilsho	1799	15	(	(	-LRB-
cord-006229-7yoilsho	1799	16	propidium	propidium	NNP
cord-006229-7yoilsho	1799	17	iodide	iodide	NNP
cord-006229-7yoilsho	1799	18	/	/	SYM
cord-006229-7yoilsho	1799	19	annexin	annexin	NN
cord-006229-7yoilsho	1799	20	V	v	NN
cord-006229-7yoilsho	1799	21	staining	staining	NN
cord-006229-7yoilsho	1799	22	)	)	-RRB-
cord-006229-7yoilsho	1799	23	and	and	CC
cord-006229-7yoilsho	1799	24	proliferation	proliferation	NN
cord-006229-7yoilsho	1799	25	(	(	-LRB-
cord-006229-7yoilsho	1799	26	carboxyfluorescein	carboxyfluorescein	NNP
cord-006229-7yoilsho	1799	27	succinimidylester	succinimidylester	NNP
cord-006229-7yoilsho	1799	28	staining	stain	VBG
cord-006229-7yoilsho	1799	29	)	)	-RRB-
cord-006229-7yoilsho	1799	30	.	.	.
cord-006229-7yoilsho	1800	1	3',5'-cGMP	3',5'-cgmp	CD
cord-006229-7yoilsho	1800	2	significantly	significantly	RB
cord-006229-7yoilsho	1800	3	increased	increase	VBN
cord-006229-7yoilsho	1800	4	apoptosis	apoptosis	NN
cord-006229-7yoilsho	1800	5	(	(	-LRB-
cord-006229-7yoilsho	1800	6	EC	EC	NNP
cord-006229-7yoilsho	1800	7	50	50	CD
cord-006229-7yoilsho	1800	8	=	=	SYM
cord-006229-7yoilsho	1800	9	75	75	CD
cord-006229-7yoilsho	1800	10	µM	µm	NN
cord-006229-7yoilsho	1800	11	)	)	-RRB-
cord-006229-7yoilsho	1800	12	and	and	CC
cord-006229-7yoilsho	1800	13	inhibited	inhibit	VBN
cord-006229-7yoilsho	1800	14	proliferation	proliferation	NN
cord-006229-7yoilsho	1800	15	(	(	-LRB-
cord-006229-7yoilsho	1800	16	EC	EC	NNP
cord-006229-7yoilsho	1800	17	50	50	CD
cord-006229-7yoilsho	1800	18	=	=	SYM
cord-006229-7yoilsho	1800	19	63	63	CD
cord-006229-7yoilsho	1800	20	µM	µM	NNP
cord-006229-7yoilsho	1800	21	)	)	-RRB-
cord-006229-7yoilsho	1800	22	of	of	IN
cord-006229-7yoilsho	1800	23	OKT3-activated	okt3-activate	VBN
cord-006229-7yoilsho	1800	24	HuT-78	HuT-78	NNP
cord-006229-7yoilsho	1800	25	cells	cell	NNS
cord-006229-7yoilsho	1800	26	.	.	.
cord-006229-7yoilsho	1801	1	Interestingly	interestingly	RB
cord-006229-7yoilsho	1801	2	,	,	,
cord-006229-7yoilsho	1801	3	also	also	RB
cord-006229-7yoilsho	1801	4	2',3'-cGMP	2',3'-cgmp	CD
cord-006229-7yoilsho	1801	5	exhibited	exhibit	VBN
cord-006229-7yoilsho	1801	6	comparable	comparable	JJ
cord-006229-7yoilsho	1801	7	effects	effect	NNS
cord-006229-7yoilsho	1801	8	on	on	IN
cord-006229-7yoilsho	1801	9	apoptosis	apoptosis	NN
cord-006229-7yoilsho	1801	10	and	and	CC
cord-006229-7yoilsho	1801	11	proliferation	proliferation	NN
cord-006229-7yoilsho	1801	12	with	with	IN
cord-006229-7yoilsho	1801	13	EC	EC	NNP
cord-006229-7yoilsho	1801	14	50	50	CD
cord-006229-7yoilsho	1801	15	values	value	NNS
cord-006229-7yoilsho	1801	16	of	of	IN
cord-006229-7yoilsho	1801	17	92	92	CD
cord-006229-7yoilsho	1801	18	µM	µM	NNS
cord-006229-7yoilsho	1801	19	and	and	CC
cord-006229-7yoilsho	1801	20	75	75	CD
cord-006229-7yoilsho	1801	21	µM	µm	NN
cord-006229-7yoilsho	1801	22	,	,	,
cord-006229-7yoilsho	1801	23	respectively	respectively	RB
cord-006229-7yoilsho	1801	24	,	,	,
cord-006229-7yoilsho	1801	25	while	while	IN
cord-006229-7yoilsho	1801	26	2',3'-cAMP	2',3'-camp	CD
cord-006229-7yoilsho	1801	27	,	,	,
cord-006229-7yoilsho	1801	28	2',3'-cCMP	2',3'-ccmp	CD
cord-006229-7yoilsho	1801	29	and	and	CC
cord-006229-7yoilsho	1801	30	2',3'-cUMP	2',3'-cump	CD
cord-006229-7yoilsho	1801	31	were	be	VBD
cord-006229-7yoilsho	1801	32	ineffective	ineffective	JJ
cord-006229-7yoilsho	1801	33	.	.	.
cord-006229-7yoilsho	1802	1	This	this	DT
cord-006229-7yoilsho	1802	2	indicates	indicate	VBZ
cord-006229-7yoilsho	1802	3	that	that	IN
cord-006229-7yoilsho	1802	4	the	the	DT
cord-006229-7yoilsho	1802	5	pro	pro	JJ
cord-006229-7yoilsho	1802	6	-	-	JJ
cord-006229-7yoilsho	1802	7	apoptotic	apoptotic	JJ
cord-006229-7yoilsho	1802	8	and	and	CC
cord-006229-7yoilsho	1802	9	antiproliferative	antiproliferative	JJ
cord-006229-7yoilsho	1802	10	action	action	NN
cord-006229-7yoilsho	1802	11	of	of	IN
cord-006229-7yoilsho	1802	12	cGMP	cGMP	NNP
cord-006229-7yoilsho	1802	13	does	do	VBZ
cord-006229-7yoilsho	1802	14	not	not	RB
cord-006229-7yoilsho	1802	15	depend	depend	VB
cord-006229-7yoilsho	1802	16	on	on	IN
cord-006229-7yoilsho	1802	17	the	the	DT
cord-006229-7yoilsho	1802	18	position	position	NN
cord-006229-7yoilsho	1802	19	of	of	IN
cord-006229-7yoilsho	1802	20	the	the	DT
cord-006229-7yoilsho	1802	21	phosphodiester	phosphodiester	NN
cord-006229-7yoilsho	1802	22	bond	bond	NN
cord-006229-7yoilsho	1802	23	.	.	.
cord-006229-7yoilsho	1803	1	We	-PRON-	PRP
cord-006229-7yoilsho	1803	2	also	also	RB
cord-006229-7yoilsho	1803	3	tested	test	VBD
cord-006229-7yoilsho	1803	4	3',5'-cGMP	3',5'-cgmp	CD
cord-006229-7yoilsho	1803	5	degradation	degradation	NN
cord-006229-7yoilsho	1803	6	products	product	NNS
cord-006229-7yoilsho	1803	7	under	under	IN
cord-006229-7yoilsho	1803	8	the	the	DT
cord-006229-7yoilsho	1803	9	same	same	JJ
cord-006229-7yoilsho	1803	10	experimental	experimental	JJ
cord-006229-7yoilsho	1803	11	conditions	condition	NNS
cord-006229-7yoilsho	1803	12	and	and	CC
cord-006229-7yoilsho	1803	13	found	find	VBD
cord-006229-7yoilsho	1803	14	that	that	IN
cord-006229-7yoilsho	1803	15	both	both	DT
cord-006229-7yoilsho	1803	16	5'-GMP	5'-gmp	CD
cord-006229-7yoilsho	1803	17	and	and	CC
cord-006229-7yoilsho	1803	18	guanosine	guanosine	NN
cord-006229-7yoilsho	1803	19	increased	increase	VBN
cord-006229-7yoilsho	1803	20	apoptosis	apoptosis	NN
cord-006229-7yoilsho	1803	21	and	and	CC
cord-006229-7yoilsho	1803	22	inhibited	inhibit	VBN
cord-006229-7yoilsho	1803	23	proliferation	proliferation	NN
cord-006229-7yoilsho	1803	24	with	with	IN
cord-006229-7yoilsho	1803	25	EC	EC	NNP
cord-006229-7yoilsho	1803	26	50	50	CD
cord-006229-7yoilsho	1803	27	-values	-value	NNS
cord-006229-7yoilsho	1804	1	between	between	IN
cord-006229-7yoilsho	1804	2	50	50	CD
cord-006229-7yoilsho	1804	3	and	and	CC
cord-006229-7yoilsho	1804	4	100	100	CD
cord-006229-7yoilsho	1804	5	µM.	µm.	JJ
cord-006229-7yoilsho	1805	1	By	by	IN
cord-006229-7yoilsho	1805	2	contrast	contrast	NN
cord-006229-7yoilsho	1805	3	,	,	,
cord-006229-7yoilsho	1805	4	adenosine	adenosine	NN
cord-006229-7yoilsho	1805	5	did	do	VBD
cord-006229-7yoilsho	1805	6	not	not	RB
cord-006229-7yoilsho	1805	7	influence	influence	VB
cord-006229-7yoilsho	1805	8	cell	cell	NN
cord-006229-7yoilsho	1805	9	growth	growth	NN
cord-006229-7yoilsho	1805	10	and	and	CC
cord-006229-7yoilsho	1805	11	viability	viability	NN
cord-006229-7yoilsho	1805	12	,	,	,
cord-006229-7yoilsho	1805	13	suggesting	suggest	VBG
cord-006229-7yoilsho	1805	14	that	that	IN
cord-006229-7yoilsho	1805	15	adenosine	adenosine	NN
cord-006229-7yoilsho	1805	16	receptors	receptor	NNS
cord-006229-7yoilsho	1805	17	are	be	VBP
cord-006229-7yoilsho	1805	18	not	not	RB
cord-006229-7yoilsho	1805	19	involved	involve	VBN
cord-006229-7yoilsho	1805	20	in	in	IN
cord-006229-7yoilsho	1805	21	the	the	DT
cord-006229-7yoilsho	1805	22	observed	observed	JJ
cord-006229-7yoilsho	1805	23	effects	effect	NNS
cord-006229-7yoilsho	1805	24	.	.	.
cord-006229-7yoilsho	1806	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	1806	2	results	result	NNS
cord-006229-7yoilsho	1806	3	suggest	suggest	VBP
cord-006229-7yoilsho	1806	4	that	that	IN
cord-006229-7yoilsho	1806	5	the	the	DT
cord-006229-7yoilsho	1806	6	guanosine	guanosine	NN
cord-006229-7yoilsho	1806	7	moiety	moiety	NN
cord-006229-7yoilsho	1806	8	is	be	VBZ
cord-006229-7yoilsho	1806	9	responsible	responsible	JJ
cord-006229-7yoilsho	1806	10	for	for	IN
cord-006229-7yoilsho	1806	11	the	the	DT
cord-006229-7yoilsho	1806	12	pro	pro	JJ
cord-006229-7yoilsho	1806	13	-	-	JJ
cord-006229-7yoilsho	1806	14	apoptotic	apoptotic	JJ
cord-006229-7yoilsho	1806	15	and	and	CC
cord-006229-7yoilsho	1806	16	antiproliferative	antiproliferative	JJ
cord-006229-7yoilsho	1806	17	effects	effect	NNS
cord-006229-7yoilsho	1806	18	of	of	IN
cord-006229-7yoilsho	1806	19	3',5'-cGMP	3',5'-cgmp	CD
cord-006229-7yoilsho	1806	20	,	,	,
cord-006229-7yoilsho	1806	21	2',3'-cGMP	2',3'-cgmp	CD
cord-006229-7yoilsho	1806	22	,	,	,
cord-006229-7yoilsho	1806	23	5'-GMP	5'-gmp	CD
cord-006229-7yoilsho	1806	24	.	.	.
cord-006229-7yoilsho	1807	1	It	-PRON-	PRP
cord-006229-7yoilsho	1807	2	has	have	VBZ
cord-006229-7yoilsho	1807	3	been	be	VBN
cord-006229-7yoilsho	1807	4	reported	report	VBN
cord-006229-7yoilsho	1807	5	earlier	early	RBR
cord-006229-7yoilsho	1807	6	that	that	IN
cord-006229-7yoilsho	1807	7	guanosine	guanosine	NN
cord-006229-7yoilsho	1807	8	is	be	VBZ
cord-006229-7yoilsho	1807	9	toxic	toxic	JJ
cord-006229-7yoilsho	1807	10	to	to	IN
cord-006229-7yoilsho	1807	11	Jurkat	Jurkat	NNP
cord-006229-7yoilsho	1807	12	cells	cell	NNS
cord-006229-7yoilsho	1807	13	,	,	,
cord-006229-7yoilsho	1807	14	another	another	DT
cord-006229-7yoilsho	1807	15	T	T	NNP
cord-006229-7yoilsho	1807	16	cell	cell	NN
cord-006229-7yoilsho	1807	17	lymphoma	lymphoma	NN
cord-006229-7yoilsho	1807	18	cell	cell	NN
cord-006229-7yoilsho	1807	19	line	line	NN
cord-006229-7yoilsho	1807	20	[	[	-LRB-
cord-006229-7yoilsho	1807	21	1	1	CD
cord-006229-7yoilsho	1807	22	]	]	-RRB-
cord-006229-7yoilsho	1807	23	.	.	.
cord-006229-7yoilsho	1808	1	3',5'-cGMP	3',5'-cgmp	CD
cord-006229-7yoilsho	1808	2	may	may	MD
cord-006229-7yoilsho	1808	3	be	be	VB
cord-006229-7yoilsho	1808	4	hydrolyzed	hydrolyze	VBN
cord-006229-7yoilsho	1808	5	by	by	IN
cord-006229-7yoilsho	1808	6	an	an	DT
cord-006229-7yoilsho	1808	7	ekto	ekto	NN
cord-006229-7yoilsho	1808	8	-	-	HYPH
cord-006229-7yoilsho	1808	9	phosphodiesterase	phosphodiesterase	NN
cord-006229-7yoilsho	1808	10	on	on	IN
cord-006229-7yoilsho	1808	11	the	the	DT
cord-006229-7yoilsho	1808	12	cell	cell	NN
cord-006229-7yoilsho	1808	13	surface	surface	NN
cord-006229-7yoilsho	1808	14	of	of	IN
cord-006229-7yoilsho	1808	15	HuT-78	hut-78	JJ
cord-006229-7yoilsho	1808	16	cells	cell	NNS
cord-006229-7yoilsho	1808	17	(	(	-LRB-
cord-006229-7yoilsho	1808	18	e.g.	e.g.	RB
cord-006229-7yoilsho	1808	19	eNPP1	eNPP1	NNS
cord-006229-7yoilsho	1808	20	)	)	-RRB-
cord-006229-7yoilsho	1808	21	,	,	,
cord-006229-7yoilsho	1808	22	yielding	yield	VBG
cord-006229-7yoilsho	1808	23	5'-GMP	5'-gmp	CD
cord-006229-7yoilsho	1808	24	,	,	,
cord-006229-7yoilsho	1808	25	which	which	WDT
cord-006229-7yoilsho	1808	26	could	could	MD
cord-006229-7yoilsho	1808	27	be	be	VB
cord-006229-7yoilsho	1808	28	further	further	RB
cord-006229-7yoilsho	1808	29	degraded	degrade	VBN
cord-006229-7yoilsho	1808	30	to	to	IN
cord-006229-7yoilsho	1808	31	guanosine	guanosine	NN
cord-006229-7yoilsho	1808	32	by	by	IN
cord-006229-7yoilsho	1808	33	the	the	DT
cord-006229-7yoilsho	1808	34	5'-ekto	5'-ekto	CD
cord-006229-7yoilsho	1808	35	-	-	HYPH
cord-006229-7yoilsho	1808	36	nukleotidase	nukleotidase	NNP
cord-006229-7yoilsho	1808	37	CD73	CD73	NNP
cord-006229-7yoilsho	1808	38	.	.	.
cord-006229-7yoilsho	1809	1	A	a	DT
cord-006229-7yoilsho	1809	2	similar	similar	JJ
cord-006229-7yoilsho	1809	3	pathway	pathway	NN
cord-006229-7yoilsho	1809	4	may	may	MD
cord-006229-7yoilsho	1809	5	lead	lead	VB
cord-006229-7yoilsho	1809	6	from	from	IN
cord-006229-7yoilsho	1809	7	2',3'-cGMP	2',3'-cgmp	CD
cord-006229-7yoilsho	1809	8	to	to	IN
cord-006229-7yoilsho	1809	9	guanosine	guanosine	NN
cord-006229-7yoilsho	1809	10	.	.	.
cord-006229-7yoilsho	1810	1	A	a	DT
cord-006229-7yoilsho	1810	2	previous	previous	JJ
cord-006229-7yoilsho	1810	3	analysis	analysis	NN
cord-006229-7yoilsho	1810	4	of	of	IN
cord-006229-7yoilsho	1810	5	phosphodiesterases	phosphodiesterase	NNS
cord-006229-7yoilsho	1810	6	(	(	-LRB-
cord-006229-7yoilsho	1810	7	PDEs	PDEs	NNP
cord-006229-7yoilsho	1810	8	)	)	-RRB-
cord-006229-7yoilsho	1810	9	revealed	reveal	VBD
cord-006229-7yoilsho	1810	10	that	that	IN
cord-006229-7yoilsho	1810	11	the	the	DT
cord-006229-7yoilsho	1810	12	dual	dual	JJ
cord-006229-7yoilsho	1810	13	-	-	HYPH
cord-006229-7yoilsho	1810	14	specific	specific	JJ
cord-006229-7yoilsho	1810	15	PDE	PDE	NNP
cord-006229-7yoilsho	1810	16	isoforms	isoform	NNS
cord-006229-7yoilsho	1810	17	3A	3a	NN
cord-006229-7yoilsho	1810	18	and	and	CC
cord-006229-7yoilsho	1810	19	3B	3b	NN
cord-006229-7yoilsho	1810	20	as	as	RB
cord-006229-7yoilsho	1810	21	well	well	RB
cord-006229-7yoilsho	1810	22	as	as	IN
cord-006229-7yoilsho	1810	23	the	the	DT
cord-006229-7yoilsho	1810	24	cGMP	cgmp	JJ
cord-006229-7yoilsho	1810	25	-	-	HYPH
cord-006229-7yoilsho	1810	26	selective	selective	JJ
cord-006229-7yoilsho	1810	27	PDE9A	PDE9A	NNS
cord-006229-7yoilsho	1810	28	also	also	RB
cord-006229-7yoilsho	1810	29	degrade	degrade	VBP
cord-006229-7yoilsho	1810	30	the	the	DT
cord-006229-7yoilsho	1810	31	emerging	emerge	VBG
cord-006229-7yoilsho	1810	32	second	second	JJ
cord-006229-7yoilsho	1810	33	messenger	messenger	NN
cord-006229-7yoilsho	1810	34	cUMP	cUMP	VBN
cord-006229-7yoilsho	1810	35	[	[	-LRB-
cord-006229-7yoilsho	1810	36	1	1	CD
cord-006229-7yoilsho	1810	37	,	,	,
cord-006229-7yoilsho	1810	38	2	2	CD
cord-006229-7yoilsho	1810	39	]	]	-RRB-
cord-006229-7yoilsho	1810	40	.	.	.
cord-006229-7yoilsho	1811	1	We	-PRON-	PRP
cord-006229-7yoilsho	1811	2	analyzed	analyze	VBD
cord-006229-7yoilsho	1811	3	the	the	DT
cord-006229-7yoilsho	1811	4	enzyme	enzyme	NN
cord-006229-7yoilsho	1811	5	kinetics	kinetics	NN
cord-006229-7yoilsho	1811	6	of	of	IN
cord-006229-7yoilsho	1811	7	PDE3B	PDE3B	NNS
cord-006229-7yoilsho	1811	8	-	-	HYPH
cord-006229-7yoilsho	1811	9	mediated	mediate	VBN
cord-006229-7yoilsho	1811	10	cUMP	cump	NN
cord-006229-7yoilsho	1811	11	-	-	NN
cord-006229-7yoilsho	1811	12	hydrolysis	hydrolysis	NN
cord-006229-7yoilsho	1811	13	using	use	VBG
cord-006229-7yoilsho	1811	14	recombinant	recombinant	JJ
cord-006229-7yoilsho	1811	15	GST	GST	NNP
cord-006229-7yoilsho	1811	16	-	-	HYPH
cord-006229-7yoilsho	1811	17	tagged	tag	VBN
cord-006229-7yoilsho	1811	18	PDE3B	PDE3B	NNP
cord-006229-7yoilsho	1811	19	and	and	CC
cord-006229-7yoilsho	1811	20	a	a	DT
cord-006229-7yoilsho	1811	21	highly	highly	RB
cord-006229-7yoilsho	1811	22	sensitive	sensitive	JJ
cord-006229-7yoilsho	1811	23	and	and	CC
cord-006229-7yoilsho	1811	24	specific	specific	JJ
cord-006229-7yoilsho	1811	25	HPLC	HPLC	NNP
cord-006229-7yoilsho	1811	26	-	-	HYPH
cord-006229-7yoilsho	1811	27	MS	MS	NNP
cord-006229-7yoilsho	1811	28	/	/	SYM
cord-006229-7yoilsho	1811	29	MS	MS	NNP
cord-006229-7yoilsho	1811	30	method	method	NN
cord-006229-7yoilsho	1811	31	.	.	.
cord-006229-7yoilsho	1812	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	1812	2	data	datum	NNS
cord-006229-7yoilsho	1812	3	show	show	VBP
cord-006229-7yoilsho	1812	4	that	that	IN
cord-006229-7yoilsho	1812	5	PDE3B	PDE3B	NNP
cord-006229-7yoilsho	1812	6	is	be	VBZ
cord-006229-7yoilsho	1812	7	a	a	DT
cord-006229-7yoilsho	1812	8	low	low	JJ
cord-006229-7yoilsho	1812	9	-	-	HYPH
cord-006229-7yoilsho	1812	10	affinity	affinity	NN
cord-006229-7yoilsho	1812	11	enzyme	enzyme	NN
cord-006229-7yoilsho	1812	12	for	for	IN
cord-006229-7yoilsho	1812	13	cUMP	cUMP	NNP
cord-006229-7yoilsho	1812	14	with	with	IN
cord-006229-7yoilsho	1812	15	a	a	DT
cord-006229-7yoilsho	1812	16	cUMP	cump	JJ
cord-006229-7yoilsho	1812	17	K	K	NNP
cord-006229-7yoilsho	1812	18	M	M	NNP
cord-006229-7yoilsho	1812	19	-value	-value	NNS
cord-006229-7yoilsho	1812	20	of	of	IN
cord-006229-7yoilsho	1813	1	>	>	XX
cord-006229-7yoilsho	1813	2	100	100	CD
cord-006229-7yoilsho	1813	3	µM.	µm.	JJ
cord-006229-7yoilsho	1814	1	The	the	DT
cord-006229-7yoilsho	1814	2	PDE3-selective	pde3-selective	JJ
cord-006229-7yoilsho	1814	3	competitive	competitive	JJ
cord-006229-7yoilsho	1814	4	inhibitor	inhibitor	NN
cord-006229-7yoilsho	1815	1	milrinone	milrinone	NNP
cord-006229-7yoilsho	1815	2	inhibited	inhibited	JJ
cord-006229-7yoilsho	1815	3	PDE3B	PDE3B	NNP
cord-006229-7yoilsho	1815	4	-	-	HYPH
cord-006229-7yoilsho	1815	5	mediated	mediate	VBN
cord-006229-7yoilsho	1815	6	cUMP	cump	NN
cord-006229-7yoilsho	1815	7	degradation	degradation	NN
cord-006229-7yoilsho	1815	8	,	,	,
cord-006229-7yoilsho	1815	9	suggesting	suggest	VBG
cord-006229-7yoilsho	1815	10	that	that	IN
cord-006229-7yoilsho	1815	11	cUMP	cUMP	NNP
cord-006229-7yoilsho	1815	12	binds	bind	VBZ
cord-006229-7yoilsho	1815	13	to	to	IN
cord-006229-7yoilsho	1815	14	the	the	DT
cord-006229-7yoilsho	1815	15	catalytic	catalytic	JJ
cord-006229-7yoilsho	1815	16	center	center	NN
cord-006229-7yoilsho	1815	17	.	.	.
cord-006229-7yoilsho	1816	1	PDE3B	PDE3B	NNS
cord-006229-7yoilsho	1816	2	is	be	VBZ
cord-006229-7yoilsho	1816	3	highly	highly	RB
cord-006229-7yoilsho	1816	4	expressed	express	VBN
cord-006229-7yoilsho	1816	5	in	in	IN
cord-006229-7yoilsho	1816	6	adipose	adipose	JJ
cord-006229-7yoilsho	1816	7	tissue	tissue	NN
cord-006229-7yoilsho	1816	8	[	[	-LRB-
cord-006229-7yoilsho	1816	9	3	3	CD
cord-006229-7yoilsho	1816	10	,	,	,
cord-006229-7yoilsho	1816	11	4	4	CD
cord-006229-7yoilsho	1816	12	]	]	-RRB-
cord-006229-7yoilsho	1816	13	.	.	.
cord-006229-7yoilsho	1817	1	Thus	thus	RB
cord-006229-7yoilsho	1817	2	,	,	,
cord-006229-7yoilsho	1817	3	we	-PRON-	PRP
cord-006229-7yoilsho	1817	4	differentiated	differentiate	VBD
cord-006229-7yoilsho	1817	5	murine	murine	JJ
cord-006229-7yoilsho	1817	6	3T3-L1-MBX	3t3-l1-mbx	CD
cord-006229-7yoilsho	1817	7	-	-	HYPH
cord-006229-7yoilsho	1817	8	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	1817	9	into	into	IN
cord-006229-7yoilsho	1817	10	adipocytes	adipocyte	NNS
cord-006229-7yoilsho	1817	11	and	and	CC
cord-006229-7yoilsho	1817	12	analyzed	analyze	VBD
cord-006229-7yoilsho	1817	13	differentiation	differentiation	NN
cord-006229-7yoilsho	1817	14	-	-	HYPH
cord-006229-7yoilsho	1817	15	dependent	dependent	JJ
cord-006229-7yoilsho	1817	16	alterations	alteration	NNS
cord-006229-7yoilsho	1817	17	of	of	IN
cord-006229-7yoilsho	1817	18	PDE3B	pde3b	JJ
cord-006229-7yoilsho	1817	19	expression	expression	NN
cord-006229-7yoilsho	1817	20	and	and	CC
cord-006229-7yoilsho	1817	21	basal	basal	NN
cord-006229-7yoilsho	1817	22	cNMP	cnmp	NN
cord-006229-7yoilsho	1817	23	-	-	HYPH
cord-006229-7yoilsho	1817	24	concentrations	concentration	NNS
cord-006229-7yoilsho	1817	25	.	.	.
cord-006229-7yoilsho	1818	1	In	in	IN
cord-006229-7yoilsho	1818	2	both	both	DT
cord-006229-7yoilsho	1818	3	differentiated	differentiated	JJ
cord-006229-7yoilsho	1818	4	and	and	CC
cord-006229-7yoilsho	1818	5	undifferentiated	undifferentiated	JJ
cord-006229-7yoilsho	1818	6	3T3-L1	3t3-l1	CD
cord-006229-7yoilsho	1818	7	cells	cell	NNS
cord-006229-7yoilsho	1818	8	cUMP	cump	NN
cord-006229-7yoilsho	1818	9	and	and	CC
cord-006229-7yoilsho	1818	10	cCMP	ccmp	NN
cord-006229-7yoilsho	1818	11	were	be	VBD
cord-006229-7yoilsho	1818	12	detected	detect	VBN
cord-006229-7yoilsho	1818	13	in	in	IN
cord-006229-7yoilsho	1818	14	addition	addition	NN
cord-006229-7yoilsho	1818	15	to	to	IN
cord-006229-7yoilsho	1818	16	the	the	DT
cord-006229-7yoilsho	1818	17	established	establish	VBN
cord-006229-7yoilsho	1818	18	second	second	JJ
cord-006229-7yoilsho	1818	19	messengers	messenger	NNS
cord-006229-7yoilsho	1818	20	cAMP	camp	NN
cord-006229-7yoilsho	1818	21	and	and	CC
cord-006229-7yoilsho	1818	22	cGMP	cGMP	NNP
cord-006229-7yoilsho	1818	23	.	.	.
cord-006229-7yoilsho	1819	1	Differentiation	differentiation	NN
cord-006229-7yoilsho	1819	2	to	to	IN
cord-006229-7yoilsho	1819	3	adipocytes	adipocyte	NNS
cord-006229-7yoilsho	1819	4	reduced	reduce	VBN
cord-006229-7yoilsho	1819	5	cAMP	camp	NN
cord-006229-7yoilsho	1819	6	and	and	CC
cord-006229-7yoilsho	1819	7	cGMP	cGMP	NNP
cord-006229-7yoilsho	1819	8	by	by	IN
cord-006229-7yoilsho	1819	9	66	66	CD
cord-006229-7yoilsho	1819	10	%	%	NN
cord-006229-7yoilsho	1819	11	and	and	CC
cord-006229-7yoilsho	1819	12	60	60	CD
cord-006229-7yoilsho	1819	13	%	%	NN
cord-006229-7yoilsho	1819	14	,	,	,
cord-006229-7yoilsho	1819	15	respectively	respectively	RB
cord-006229-7yoilsho	1819	16	,	,	,
cord-006229-7yoilsho	1819	17	while	while	IN
cord-006229-7yoilsho	1819	18	cCMP	ccmp	NN
cord-006229-7yoilsho	1819	19	was	be	VBD
cord-006229-7yoilsho	1819	20	reduced	reduce	VBN
cord-006229-7yoilsho	1819	21	by	by	IN
cord-006229-7yoilsho	1819	22	78	78	CD
cord-006229-7yoilsho	1819	23	%	%	NN
cord-006229-7yoilsho	1819	24	and	and	CC
cord-006229-7yoilsho	1819	25	cUMP	cUMP	MD
cord-006229-7yoilsho	1819	26	even	even	RB
cord-006229-7yoilsho	1819	27	by	by	IN
cord-006229-7yoilsho	1819	28	85	85	CD
cord-006229-7yoilsho	1819	29	%	%	NN
cord-006229-7yoilsho	1819	30	.	.	.
cord-006229-7yoilsho	1820	1	These	these	DT
cord-006229-7yoilsho	1820	2	findings	finding	NNS
cord-006229-7yoilsho	1820	3	suggest	suggest	VBP
cord-006229-7yoilsho	1820	4	that	that	IN
cord-006229-7yoilsho	1820	5	cUMP	cUMP	NNP
cord-006229-7yoilsho	1820	6	plays	play	VBZ
cord-006229-7yoilsho	1820	7	a	a	DT
cord-006229-7yoilsho	1820	8	distinct	distinct	JJ
cord-006229-7yoilsho	1820	9	role	role	NN
cord-006229-7yoilsho	1820	10	in	in	IN
cord-006229-7yoilsho	1820	11	adipocyte	adipocyte	JJ
cord-006229-7yoilsho	1820	12	differentiation	differentiation	NN
cord-006229-7yoilsho	1820	13	.	.	.
cord-006229-7yoilsho	1821	1	The	the	DT
cord-006229-7yoilsho	1821	2	cUMP	cump	JJ
cord-006229-7yoilsho	1821	3	-	-	HYPH
cord-006229-7yoilsho	1821	4	hydrolyzing	hydrolyzing	NNP
cord-006229-7yoilsho	1821	5	PDE3B	PDE3B	NNS
cord-006229-7yoilsho	1821	6	was	be	VBD
cord-006229-7yoilsho	1821	7	upregulated	upregulate	VBN
cord-006229-7yoilsho	1821	8	~1000-fold	~1000-fold	NFP
cord-006229-7yoilsho	1821	9	on	on	IN
cord-006229-7yoilsho	1821	10	mRNA	mrna	NN
cord-006229-7yoilsho	1821	11	level	level	NN
cord-006229-7yoilsho	1821	12	after	after	IN
cord-006229-7yoilsho	1821	13	adipocyte	adipocyte	NN
cord-006229-7yoilsho	1821	14	differentiation	differentiation	NN
cord-006229-7yoilsho	1821	15	,	,	,
cord-006229-7yoilsho	1821	16	which	which	WDT
cord-006229-7yoilsho	1821	17	may	may	MD
cord-006229-7yoilsho	1821	18	contribute	contribute	VB
cord-006229-7yoilsho	1821	19	to	to	IN
cord-006229-7yoilsho	1821	20	the	the	DT
cord-006229-7yoilsho	1821	21	observed	observed	JJ
cord-006229-7yoilsho	1821	22	reduction	reduction	NN
cord-006229-7yoilsho	1821	23	of	of	IN
cord-006229-7yoilsho	1821	24	basal	basal	NN
cord-006229-7yoilsho	1821	25	cUMP	cump	NN
cord-006229-7yoilsho	1821	26	concentrations	concentration	NNS
cord-006229-7yoilsho	1821	27	.	.	.
cord-006229-7yoilsho	1822	1	We	-PRON-	PRP
cord-006229-7yoilsho	1822	2	currently	currently	RB
cord-006229-7yoilsho	1822	3	investigate	investigate	VBP
cord-006229-7yoilsho	1822	4	the	the	DT
cord-006229-7yoilsho	1822	5	potential	potential	JJ
cord-006229-7yoilsho	1822	6	biological	biological	JJ
cord-006229-7yoilsho	1822	7	role	role	NN
cord-006229-7yoilsho	1822	8	of	of	IN
cord-006229-7yoilsho	1822	9	cUMP	cUMP	NNP
cord-006229-7yoilsho	1823	1	in	in	IN
cord-006229-7yoilsho	1823	2	differentiation	differentiation	NN
cord-006229-7yoilsho	1823	3	and	and	CC
cord-006229-7yoilsho	1823	4	lipolysis	lipolysis	NN
cord-006229-7yoilsho	1823	5	experiments	experiment	NNS
cord-006229-7yoilsho	1823	6	,	,	,
cord-006229-7yoilsho	1823	7	analyzing	analyze	VBG
cord-006229-7yoilsho	1823	8	the	the	DT
cord-006229-7yoilsho	1823	9	effects	effect	NNS
cord-006229-7yoilsho	1823	10	of	of	IN
cord-006229-7yoilsho	1823	11	the	the	DT
cord-006229-7yoilsho	1823	12	membrane	membrane	NN
cord-006229-7yoilsho	1823	13	-	-	HYPH
cord-006229-7yoilsho	1823	14	permeant	permeant	JJ
cord-006229-7yoilsho	1823	15	cUMPacetoxymethyl	cumpacetoxymethyl	NN
cord-006229-7yoilsho	1823	16	ester	ester	NN
cord-006229-7yoilsho	1823	17	cUMP	cump	NN
cord-006229-7yoilsho	1823	18	-	-	HYPH
cord-006229-7yoilsho	1823	19	AM	AM	NNP
cord-006229-7yoilsho	1823	20	.	.	.
cord-006229-7yoilsho	1824	1	In	in	IN
cord-006229-7yoilsho	1824	2	future	future	JJ
cord-006229-7yoilsho	1824	3	experiments	experiment	NNS
cord-006229-7yoilsho	1824	4	,	,	,
cord-006229-7yoilsho	1824	5	we	-PRON-	PRP
cord-006229-7yoilsho	1824	6	will	will	MD
cord-006229-7yoilsho	1824	7	also	also	RB
cord-006229-7yoilsho	1824	8	analyze	analyze	VB
cord-006229-7yoilsho	1824	9	the	the	DT
cord-006229-7yoilsho	1824	10	enzyme	enzyme	NN
cord-006229-7yoilsho	1824	11	kinetics	kinetics	NN
cord-006229-7yoilsho	1824	12	of	of	IN
cord-006229-7yoilsho	1824	13	PDE9A	PDE9A	NNS
cord-006229-7yoilsho	1824	14	-	-	HYPH
cord-006229-7yoilsho	1824	15	mediated	mediate	VBN
cord-006229-7yoilsho	1824	16	cUMP	cump	NN
cord-006229-7yoilsho	1824	17	hydrolysis	hydrolysis	NN
cord-006229-7yoilsho	1824	18	.	.	.
cord-006229-7yoilsho	1825	1	PDE9A	PDE9A	NNP
cord-006229-7yoilsho	1825	2	is	be	VBZ
cord-006229-7yoilsho	1825	3	the	the	DT
cord-006229-7yoilsho	1825	4	first	first	JJ
cord-006229-7yoilsho	1825	5	example	example	NN
cord-006229-7yoilsho	1825	6	of	of	IN
cord-006229-7yoilsho	1825	7	a	a	DT
cord-006229-7yoilsho	1825	8	cGMP-"specific	cGMP-"specific	NNP
cord-006229-7yoilsho	1825	9	"	"	``
cord-006229-7yoilsho	1825	10	cUMP	cump	JJ
cord-006229-7yoilsho	1825	11	-	-	HYPH
cord-006229-7yoilsho	1825	12	hydrolyzing	hydrolyze	VBG
cord-006229-7yoilsho	1825	13	PDE	pde	NN
cord-006229-7yoilsho	1825	14	.	.	.
cord-006229-7yoilsho	1826	1	Background	background	NN
cord-006229-7yoilsho	1826	2	:	:	:
cord-006229-7yoilsho	1827	1	cGMP	cGMP	NNP
cord-006229-7yoilsho	1827	2	and	and	CC
cord-006229-7yoilsho	1827	3	cAMP	camp	NN
cord-006229-7yoilsho	1827	4	are	be	VBP
cord-006229-7yoilsho	1827	5	cyclic	cyclic	JJ
cord-006229-7yoilsho	1827	6	nucleotide	nucleotide	JJ
cord-006229-7yoilsho	1827	7	messengers	messenger	NNS
cord-006229-7yoilsho	1827	8	relevant	relevant	JJ
cord-006229-7yoilsho	1827	9	to	to	IN
cord-006229-7yoilsho	1827	10	many	many	JJ
cord-006229-7yoilsho	1827	11	physiological	physiological	JJ
cord-006229-7yoilsho	1827	12	and	and	CC
cord-006229-7yoilsho	1827	13	pathophysiological	pathophysiological	JJ
cord-006229-7yoilsho	1827	14	conditions	condition	NNS
cord-006229-7yoilsho	1827	15	.	.	.
cord-006229-7yoilsho	1828	1	Live	live	JJ
cord-006229-7yoilsho	1828	2	-	-	HYPH
cord-006229-7yoilsho	1828	3	cell	cell	NN
cord-006229-7yoilsho	1828	4	imaging	imaging	NN
cord-006229-7yoilsho	1828	5	with	with	IN
cord-006229-7yoilsho	1828	6	FRET	fret	NN
cord-006229-7yoilsho	1828	7	-	-	HYPH
cord-006229-7yoilsho	1828	8	based	base	VBN
cord-006229-7yoilsho	1828	9	biosensors	biosensor	NNS
cord-006229-7yoilsho	1828	10	is	be	VBZ
cord-006229-7yoilsho	1828	11	a	a	DT
cord-006229-7yoilsho	1828	12	powerful	powerful	JJ
cord-006229-7yoilsho	1828	13	method	method	NN
cord-006229-7yoilsho	1828	14	to	to	TO
cord-006229-7yoilsho	1828	15	study	study	VB
cord-006229-7yoilsho	1828	16	the	the	DT
cord-006229-7yoilsho	1828	17	spatiotemporal	spatiotemporal	JJ
cord-006229-7yoilsho	1828	18	dynamics	dynamic	NNS
cord-006229-7yoilsho	1828	19	of	of	IN
cord-006229-7yoilsho	1828	20	cGMP	cGMP	NNP
cord-006229-7yoilsho	1828	21	and	and	CC
cord-006229-7yoilsho	1828	22	cAMP	camp	NN
cord-006229-7yoilsho	1828	23	under	under	IN
cord-006229-7yoilsho	1828	24	close	close	JJ
cord-006229-7yoilsho	1828	25	-	-	HYPH
cord-006229-7yoilsho	1828	26	to	to	IN
cord-006229-7yoilsho	1828	27	-	-	HYPH
cord-006229-7yoilsho	1828	28	native	native	JJ
cord-006229-7yoilsho	1828	29	conditions	condition	NNS
cord-006229-7yoilsho	1828	30	.	.	.
cord-006229-7yoilsho	1829	1	However	however	RB
cord-006229-7yoilsho	1829	2	,	,	,
cord-006229-7yoilsho	1829	3	with	with	IN
cord-006229-7yoilsho	1829	4	the	the	DT
cord-006229-7yoilsho	1829	5	existing	exist	VBG
cord-006229-7yoilsho	1829	6	biosensors	biosensor	NNS
cord-006229-7yoilsho	1829	7	it	-PRON-	PRP
cord-006229-7yoilsho	1829	8	is	be	VBZ
cord-006229-7yoilsho	1829	9	difficult	difficult	JJ
cord-006229-7yoilsho	1829	10	to	to	TO
cord-006229-7yoilsho	1829	11	resolve	resolve	VB
cord-006229-7yoilsho	1829	12	potential	potential	JJ
cord-006229-7yoilsho	1829	13	membrane	membrane	NN
cord-006229-7yoilsho	1829	14	-	-	HYPH
cord-006229-7yoilsho	1829	15	associated	associate	VBN
cord-006229-7yoilsho	1829	16	cGMP	cGMP	NNP
cord-006229-7yoilsho	1829	17	microdomains	microdomain	NNS
cord-006229-7yoilsho	1829	18	and	and	CC
cord-006229-7yoilsho	1829	19	to	to	TO
cord-006229-7yoilsho	1829	20	monitor	monitor	VB
cord-006229-7yoilsho	1829	21	cGMP	cGMP	NNP
cord-006229-7yoilsho	1829	22	and	and	CC
cord-006229-7yoilsho	1829	23	cAMP	camp	NN
cord-006229-7yoilsho	1829	24	signals	signal	NNS
cord-006229-7yoilsho	1829	25	in	in	IN
cord-006229-7yoilsho	1829	26	parallel	parallel	NN
cord-006229-7yoilsho	1829	27	in	in	IN
cord-006229-7yoilsho	1829	28	the	the	DT
cord-006229-7yoilsho	1829	29	same	same	JJ
cord-006229-7yoilsho	1829	30	cell	cell	NN
cord-006229-7yoilsho	1829	31	.	.	.
cord-006229-7yoilsho	1830	1	We	-PRON-	PRP
cord-006229-7yoilsho	1830	2	have	have	VBP
cord-006229-7yoilsho	1830	3	generated	generate	VBN
cord-006229-7yoilsho	1830	4	novel	novel	JJ
cord-006229-7yoilsho	1830	5	versions	version	NNS
cord-006229-7yoilsho	1830	6	of	of	IN
cord-006229-7yoilsho	1830	7	the	the	DT
cord-006229-7yoilsho	1830	8	"	"	``
cord-006229-7yoilsho	1830	9	green	green	JJ
cord-006229-7yoilsho	1830	10	"	"	''
cord-006229-7yoilsho	1830	11	CFP	CFP	NNP
cord-006229-7yoilsho	1830	12	/	/	SYM
cord-006229-7yoilsho	1830	13	YFP	YFP	NNP
cord-006229-7yoilsho	1830	14	-	-	HYPH
cord-006229-7yoilsho	1830	15	based	base	VBN
cord-006229-7yoilsho	1830	16	cytosolic	cytosolic	JJ
cord-006229-7yoilsho	1830	17	cGMP	cgmp	JJ
cord-006229-7yoilsho	1830	18	biosensor	biosensor	NN
cord-006229-7yoilsho	1830	19	,	,	,
cord-006229-7yoilsho	1830	20	cGi500	cGi500	NNP
cord-006229-7yoilsho	1830	21	.	.	.
cord-006229-7yoilsho	1831	1	They	-PRON-	PRP
cord-006229-7yoilsho	1831	2	comprise	comprise	VBP
cord-006229-7yoilsho	1831	3	a	a	DT
cord-006229-7yoilsho	1831	4	"	"	``
cord-006229-7yoilsho	1831	5	green	green	JJ
cord-006229-7yoilsho	1831	6	"	"	''
cord-006229-7yoilsho	1831	7	membrane	membrane	NN
cord-006229-7yoilsho	1831	8	-	-	HYPH
cord-006229-7yoilsho	1831	9	targeted	target	VBN
cord-006229-7yoilsho	1831	10	version	version	NN
cord-006229-7yoilsho	1831	11	(	(	-LRB-
cord-006229-7yoilsho	1831	12	mcGi500	mcGi500	''
cord-006229-7yoilsho	1831	13	)	)	-RRB-
cord-006229-7yoilsho	1831	14	and	and	CC
cord-006229-7yoilsho	1831	15	a	a	DT
cord-006229-7yoilsho	1831	16	"	"	``
cord-006229-7yoilsho	1831	17	red	red	JJ
cord-006229-7yoilsho	1831	18	"	"	''
cord-006229-7yoilsho	1831	19	variant	variant	NN
cord-006229-7yoilsho	1831	20	(	(	-LRB-
cord-006229-7yoilsho	1831	21	red	red	NNP
cord-006229-7yoilsho	1831	22	cGi500	cGi500	NNP
cord-006229-7yoilsho	1831	23	)	)	-RRB-
cord-006229-7yoilsho	1831	24	that	that	WDT
cord-006229-7yoilsho	1831	25	contains	contain	VBZ
cord-006229-7yoilsho	1831	26	the	the	DT
cord-006229-7yoilsho	1831	27	fluorophores	fluorophores	JJ
cord-006229-7yoilsho	1831	28	tSapphire	tSapphire	NNP
cord-006229-7yoilsho	1831	29	and	and	CC
cord-006229-7yoilsho	1831	30	Dimer2	Dimer2	NNP
cord-006229-7yoilsho	1831	31	.	.	.
cord-006229-7yoilsho	1832	1	Methods	method	NNS
cord-006229-7yoilsho	1832	2	:	:	:
cord-006229-7yoilsho	1833	1	The	the	DT
cord-006229-7yoilsho	1833	2	sensors	sensor	NNS
cord-006229-7yoilsho	1833	3	were	be	VBD
cord-006229-7yoilsho	1833	4	expressed	express	VBN
cord-006229-7yoilsho	1833	5	and	and	CC
cord-006229-7yoilsho	1833	6	characterised	characterise	VBN
cord-006229-7yoilsho	1833	7	in	in	IN
cord-006229-7yoilsho	1833	8	primary	primary	JJ
cord-006229-7yoilsho	1833	9	vascular	vascular	JJ
cord-006229-7yoilsho	1833	10	smooth	smooth	JJ
cord-006229-7yoilsho	1833	11	muscle	muscle	NN
cord-006229-7yoilsho	1833	12	cells	cell	NNS
cord-006229-7yoilsho	1833	13	(	(	-LRB-
cord-006229-7yoilsho	1833	14	VSMCs	vsmc	NNS
cord-006229-7yoilsho	1833	15	)	)	-RRB-
cord-006229-7yoilsho	1833	16	.	.	.
cord-006229-7yoilsho	1834	1	Intracellular	Intracellular	NNP
cord-006229-7yoilsho	1834	2	cGMP	cGMP	NNP
cord-006229-7yoilsho	1834	3	was	be	VBD
cord-006229-7yoilsho	1834	4	elevated	elevate	VBN
cord-006229-7yoilsho	1834	5	in	in	IN
cord-006229-7yoilsho	1834	6	intact	intact	JJ
cord-006229-7yoilsho	1834	7	VSMCs	vsmc	NNS
cord-006229-7yoilsho	1834	8	by	by	IN
cord-006229-7yoilsho	1834	9	application	application	NN
cord-006229-7yoilsho	1834	10	of	of	IN
cord-006229-7yoilsho	1834	11	a	a	DT
cord-006229-7yoilsho	1834	12	nitric	nitric	JJ
cord-006229-7yoilsho	1834	13	oxide	oxide	NN
cord-006229-7yoilsho	1834	14	donor	donor	NN
cord-006229-7yoilsho	1834	15	or	or	CC
cord-006229-7yoilsho	1834	16	natriuretic	natriuretic	JJ
cord-006229-7yoilsho	1834	17	peptides	peptide	NNS
cord-006229-7yoilsho	1834	18	,	,	,
cord-006229-7yoilsho	1834	19	and	and	CC
cord-006229-7yoilsho	1834	20	the	the	DT
cord-006229-7yoilsho	1834	21	sensor	sensor	NN
cord-006229-7yoilsho	1834	22	's	's	POS
cord-006229-7yoilsho	1834	23	sensitivity	sensitivity	NN
cord-006229-7yoilsho	1834	24	to	to	IN
cord-006229-7yoilsho	1834	25	each	each	DT
cord-006229-7yoilsho	1834	26	stimulation	stimulation	NN
cord-006229-7yoilsho	1834	27	and	and	CC
cord-006229-7yoilsho	1834	28	its	-PRON-	PRP$
cord-006229-7yoilsho	1834	29	signal	signal	NN
cord-006229-7yoilsho	1834	30	-	-	HYPH
cord-006229-7yoilsho	1834	31	to	to	IN
cord-006229-7yoilsho	1834	32	-	-	HYPH
cord-006229-7yoilsho	1834	33	noise	noise	NN
cord-006229-7yoilsho	1834	34	ratio	ratio	NN
cord-006229-7yoilsho	1834	35	were	be	VBD
cord-006229-7yoilsho	1834	36	determined	determine	VBN
cord-006229-7yoilsho	1834	37	.	.	.
cord-006229-7yoilsho	1835	1	To	to	TO
cord-006229-7yoilsho	1835	2	test	test	VB
cord-006229-7yoilsho	1835	3	each	each	DT
cord-006229-7yoilsho	1835	4	sensor	sensor	NN
cord-006229-7yoilsho	1835	5	's	's	POS
cord-006229-7yoilsho	1835	6	sensitivity	sensitivity	NN
cord-006229-7yoilsho	1835	7	and	and	CC
cord-006229-7yoilsho	1835	8	specificity	specificity	NN
cord-006229-7yoilsho	1835	9	for	for	IN
cord-006229-7yoilsho	1835	10	cGMP	cGMP	NNP
cord-006229-7yoilsho	1835	11	versus	versus	IN
cord-006229-7yoilsho	1835	12	cAMP	camp	NN
cord-006229-7yoilsho	1835	13	,	,	,
cord-006229-7yoilsho	1835	14	sensor	sensor	NN
cord-006229-7yoilsho	1835	15	-	-	HYPH
cord-006229-7yoilsho	1835	16	expressing	express	VBG
cord-006229-7yoilsho	1835	17	cells	cell	NNS
cord-006229-7yoilsho	1835	18	were	be	VBD
cord-006229-7yoilsho	1835	19	permeabilised	permeabilise	VBN
cord-006229-7yoilsho	1835	20	with	with	IN
cord-006229-7yoilsho	1835	21	β	β	NN
cord-006229-7yoilsho	1835	22	-	-	HYPH
cord-006229-7yoilsho	1835	23	escin	escin	NNS
cord-006229-7yoilsho	1835	24	and	and	CC
cord-006229-7yoilsho	1835	25	exposed	expose	VBN
cord-006229-7yoilsho	1835	26	to	to	IN
cord-006229-7yoilsho	1835	27	defined	define	VBN
cord-006229-7yoilsho	1835	28	concentrations	concentration	NNS
cord-006229-7yoilsho	1835	29	of	of	IN
cord-006229-7yoilsho	1835	30	cyclic	cyclic	JJ
cord-006229-7yoilsho	1835	31	nucleotides	nucleotide	NNS
cord-006229-7yoilsho	1835	32	.	.	.
cord-006229-7yoilsho	1836	1	Results	result	NNS
cord-006229-7yoilsho	1836	2	:	:	:
cord-006229-7yoilsho	1837	1	The	the	DT
cord-006229-7yoilsho	1837	2	original	original	JJ
cord-006229-7yoilsho	1837	3	cGi500	cGi500	NNP
cord-006229-7yoilsho	1837	4	sensor	sensor	NN
cord-006229-7yoilsho	1837	5	showed	show	VBD
cord-006229-7yoilsho	1837	6	a	a	DT
cord-006229-7yoilsho	1837	7	good	good	JJ
cord-006229-7yoilsho	1837	8	signal	signal	NN
cord-006229-7yoilsho	1837	9	-	-	HYPH
cord-006229-7yoilsho	1837	10	to	to	IN
cord-006229-7yoilsho	1837	11	-	-	HYPH
cord-006229-7yoilsho	1837	12	noise	noise	NN
cord-006229-7yoilsho	1837	13	ratio	ratio	NN
cord-006229-7yoilsho	1837	14	,	,	,
cord-006229-7yoilsho	1837	15	an	an	DT
cord-006229-7yoilsho	1837	16	EC	EC	NNP
cord-006229-7yoilsho	1837	17	50	50	CD
cord-006229-7yoilsho	1837	18	value	value	NN
cord-006229-7yoilsho	1837	19	of	of	IN
cord-006229-7yoilsho	1837	20	≈1.1	≈1.1	.
cord-006229-7yoilsho	1837	21	µM	µM	NFP
cord-006229-7yoilsho	1837	22	for	for	IN
cord-006229-7yoilsho	1837	23	cGMP	cGMP	NNP
cord-006229-7yoilsho	1837	24	,	,	,
cord-006229-7yoilsho	1837	25	and	and	CC
cord-006229-7yoilsho	1837	26	a	a	DT
cord-006229-7yoilsho	1837	27	high	high	JJ
cord-006229-7yoilsho	1837	28	selectivity	selectivity	NN
cord-006229-7yoilsho	1837	29	for	for	IN
cord-006229-7yoilsho	1837	30	cGMP	cGMP	NNP
cord-006229-7yoilsho	1837	31	over	over	IN
cord-006229-7yoilsho	1838	1	cAMP	camp	NN
cord-006229-7yoilsho	1838	2	(	(	-LRB-
cord-006229-7yoilsho	1838	3	>	>	XX
cord-006229-7yoilsho	1838	4	100-fold	100-fold	CD
cord-006229-7yoilsho	1838	5	)	)	-RRB-
cord-006229-7yoilsho	1838	6	.	.	.
cord-006229-7yoilsho	1839	1	FlincG3	FlincG3	NNP
cord-006229-7yoilsho	1839	2	,	,	,
cord-006229-7yoilsho	1839	3	a	a	DT
cord-006229-7yoilsho	1839	4	non	non	JJ
cord-006229-7yoilsho	1839	5	-	-	JJ
cord-006229-7yoilsho	1839	6	FRET	fret	NN
cord-006229-7yoilsho	1839	7	-	-	HYPH
cord-006229-7yoilsho	1839	8	based	base	VBN
cord-006229-7yoilsho	1839	9	cGMP	cGMP	NNP
cord-006229-7yoilsho	1839	10	sensor	sensor	NN
cord-006229-7yoilsho	1839	11	,	,	,
cord-006229-7yoilsho	1839	12	showed	show	VBD
cord-006229-7yoilsho	1839	13	similar	similar	JJ
cord-006229-7yoilsho	1839	14	properties	property	NNS
cord-006229-7yoilsho	1839	15	as	as	IN
cord-006229-7yoilsho	1839	16	cGi500	cGi500	NNP
cord-006229-7yoilsho	1839	17	.	.	.
cord-006229-7yoilsho	1840	1	The	the	DT
cord-006229-7yoilsho	1840	2	new	new	JJ
cord-006229-7yoilsho	1840	3	membrane	membrane	NN
cord-006229-7yoilsho	1840	4	-	-	HYPH
cord-006229-7yoilsho	1840	5	targeted	target	VBN
cord-006229-7yoilsho	1840	6	mcGi500	mcGi500	''
cord-006229-7yoilsho	1840	7	and	and	CC
cord-006229-7yoilsho	1840	8	the	the	DT
cord-006229-7yoilsho	1840	9	new	new	JJ
cord-006229-7yoilsho	1840	10	red	red	NN
cord-006229-7yoilsho	1840	11	cGi500	cGi500	NNP
cord-006229-7yoilsho	1840	12	displayed	display	VBD
cord-006229-7yoilsho	1840	13	EC	EC	NNP
cord-006229-7yoilsho	1840	14	50	50	CD
cord-006229-7yoilsho	1840	15	values	value	NNS
cord-006229-7yoilsho	1840	16	of	of	IN
cord-006229-7yoilsho	1840	17	≈0.4	≈0.4	.
cord-006229-7yoilsho	1840	18	µM	µM	NNP
cord-006229-7yoilsho	1840	19	cGMP	cGMP	NNP
cord-006229-7yoilsho	1840	20	and	and	CC
cord-006229-7yoilsho	1840	21	a	a	DT
cord-006229-7yoilsho	1840	22	high	high	JJ
cord-006229-7yoilsho	1840	23	selectivity	selectivity	NN
cord-006229-7yoilsho	1840	24	for	for	IN
cord-006229-7yoilsho	1840	25	cGMP	cGMP	NNP
cord-006229-7yoilsho	1840	26	over	over	IN
cord-006229-7yoilsho	1841	1	cAMP	camp	NN
cord-006229-7yoilsho	1841	2	(	(	-LRB-
cord-006229-7yoilsho	1841	3	>	>	NFP
cord-006229-7yoilsho	1841	4	300-fold	300-fold	CD
cord-006229-7yoilsho	1841	5	)	)	-RRB-
cord-006229-7yoilsho	1841	6	.	.	.
cord-006229-7yoilsho	1842	1	In	in	IN
cord-006229-7yoilsho	1842	2	VSMCs	vsmc	NNS
cord-006229-7yoilsho	1842	3	,	,	,
cord-006229-7yoilsho	1842	4	the	the	DT
cord-006229-7yoilsho	1842	5	red	red	NN
cord-006229-7yoilsho	1842	6	cGi500	cGi500	NNP
cord-006229-7yoilsho	1842	7	showed	show	VBD
cord-006229-7yoilsho	1842	8	a	a	DT
cord-006229-7yoilsho	1842	9	better	well	JJR
cord-006229-7yoilsho	1842	10	signal	signal	NN
cord-006229-7yoilsho	1842	11	-	-	HYPH
cord-006229-7yoilsho	1842	12	to	to	IN
cord-006229-7yoilsho	1842	13	-	-	HYPH
cord-006229-7yoilsho	1842	14	noise	noise	NN
cord-006229-7yoilsho	1842	15	ratio	ratio	NN
cord-006229-7yoilsho	1842	16	than	than	IN
cord-006229-7yoilsho	1842	17	the	the	DT
cord-006229-7yoilsho	1842	18	previously	previously	RB
cord-006229-7yoilsho	1842	19	described	describe	VBN
cord-006229-7yoilsho	1842	20	"	"	``
cord-006229-7yoilsho	1842	21	red	red	JJ
cord-006229-7yoilsho	1842	22	"	"	''
cord-006229-7yoilsho	1842	23	cGMP	cGMP	NNP
cord-006229-7yoilsho	1842	24	sensor	sensor	NN
cord-006229-7yoilsho	1842	25	,	,	,
cord-006229-7yoilsho	1842	26	red	red	JJ
cord-006229-7yoilsho	1842	27	cGES	cges	NN
cord-006229-7yoilsho	1842	28	-	-	HYPH
cord-006229-7yoilsho	1842	29	DE5	DE5	NNP
cord-006229-7yoilsho	1842	30	.	.	.
cord-006229-7yoilsho	1843	1	The	the	DT
cord-006229-7yoilsho	1843	2	"	"	``
cord-006229-7yoilsho	1843	3	green	green	JJ
cord-006229-7yoilsho	1843	4	"	"	''
cord-006229-7yoilsho	1843	5	FRET	fret	NN
cord-006229-7yoilsho	1843	6	-	-	HYPH
cord-006229-7yoilsho	1843	7	based	base	VBN
cord-006229-7yoilsho	1843	8	cAMP	camp	NN
cord-006229-7yoilsho	1843	9	sensor	sensor	NN
cord-006229-7yoilsho	1843	10	,	,	,
cord-006229-7yoilsho	1843	11	Epac1-camps	Epac1-camps	NNP
cord-006229-7yoilsho	1843	12	,	,	,
cord-006229-7yoilsho	1843	13	showed	show	VBD
cord-006229-7yoilsho	1843	14	a	a	DT
cord-006229-7yoilsho	1843	15	signal	signal	NN
cord-006229-7yoilsho	1843	16	-	-	HYPH
cord-006229-7yoilsho	1843	17	to	to	IN
cord-006229-7yoilsho	1843	18	-	-	HYPH
cord-006229-7yoilsho	1843	19	noise	noise	NN
cord-006229-7yoilsho	1843	20	ratio	ratio	NN
cord-006229-7yoilsho	1843	21	comparable	comparable	JJ
cord-006229-7yoilsho	1843	22	to	to	IN
cord-006229-7yoilsho	1843	23	that	that	DT
cord-006229-7yoilsho	1843	24	of	of	IN
cord-006229-7yoilsho	1843	25	cGi500	cGi500	NNP
cord-006229-7yoilsho	1843	26	,	,	,
cord-006229-7yoilsho	1843	27	an	an	DT
cord-006229-7yoilsho	1843	28	EC	EC	NNP
cord-006229-7yoilsho	1843	29	50	50	CD
cord-006229-7yoilsho	1843	30	value	value	NN
cord-006229-7yoilsho	1843	31	of	of	IN
cord-006229-7yoilsho	1843	32	≈3	≈3	NN
cord-006229-7yoilsho	1843	33	µM	µm	NN
cord-006229-7yoilsho	1843	34	for	for	IN
cord-006229-7yoilsho	1843	35	cAMP	camp	NN
cord-006229-7yoilsho	1843	36	and	and	CC
cord-006229-7yoilsho	1843	37	a	a	DT
cord-006229-7yoilsho	1843	38	selectivity	selectivity	NN
cord-006229-7yoilsho	1843	39	for	for	IN
cord-006229-7yoilsho	1843	40	cAMP	camp	NN
cord-006229-7yoilsho	1843	41	over	over	IN
cord-006229-7yoilsho	1843	42	cGMP	cGMP	NNP
cord-006229-7yoilsho	1843	43	of	of	IN
cord-006229-7yoilsho	1843	44	≈6-fold	≈6-fold	NNP
cord-006229-7yoilsho	1843	45	.	.	.
cord-006229-7yoilsho	1844	1	Finally	finally	RB
cord-006229-7yoilsho	1844	2	,	,	,
cord-006229-7yoilsho	1844	3	imaging	imaging	NN
cord-006229-7yoilsho	1844	4	of	of	IN
cord-006229-7yoilsho	1844	5	cells	cell	NNS
cord-006229-7yoilsho	1844	6	expressing	express	VBG
cord-006229-7yoilsho	1844	7	both	both	DT
cord-006229-7yoilsho	1844	8	the	the	DT
cord-006229-7yoilsho	1844	9	Epac1-camps	Epac1-camps	NNP
cord-006229-7yoilsho	1844	10	and	and	CC
cord-006229-7yoilsho	1844	11	the	the	DT
cord-006229-7yoilsho	1844	12	red	red	NN
cord-006229-7yoilsho	1844	13	cGi500	cGi500	NNP
cord-006229-7yoilsho	1844	14	demonstrated	demonstrate	VBD
cord-006229-7yoilsho	1844	15	the	the	DT
cord-006229-7yoilsho	1844	16	feasibility	feasibility	NN
cord-006229-7yoilsho	1844	17	of	of	IN
cord-006229-7yoilsho	1844	18	combined	combine	VBN
cord-006229-7yoilsho	1844	19	visualisation	visualisation	NN
cord-006229-7yoilsho	1844	20	of	of	IN
cord-006229-7yoilsho	1844	21	cAMP	camp	NN
cord-006229-7yoilsho	1844	22	and	and	CC
cord-006229-7yoilsho	1844	23	cGMP	cGMP	NNP
cord-006229-7yoilsho	1844	24	signals	signal	NNS
cord-006229-7yoilsho	1844	25	in	in	IN
cord-006229-7yoilsho	1844	26	the	the	DT
cord-006229-7yoilsho	1844	27	same	same	JJ
cord-006229-7yoilsho	1844	28	cell	cell	NN
cord-006229-7yoilsho	1844	29	.	.	.
cord-006229-7yoilsho	1845	1	The	the	DT
cord-006229-7yoilsho	1845	2	new	new	JJ
cord-006229-7yoilsho	1845	3	cGMP	cgmp	JJ
cord-006229-7yoilsho	1845	4	biosensors	biosensor	NNS
cord-006229-7yoilsho	1845	5	should	should	MD
cord-006229-7yoilsho	1845	6	be	be	VB
cord-006229-7yoilsho	1845	7	useful	useful	JJ
cord-006229-7yoilsho	1845	8	for	for	IN
cord-006229-7yoilsho	1845	9	a	a	DT
cord-006229-7yoilsho	1845	10	broad	broad	JJ
cord-006229-7yoilsho	1845	11	spectrum	spectrum	NN
cord-006229-7yoilsho	1845	12	of	of	IN
cord-006229-7yoilsho	1845	13	applications	application	NNS
cord-006229-7yoilsho	1845	14	requiring	require	VBG
cord-006229-7yoilsho	1845	15	real	real	JJ
cord-006229-7yoilsho	1845	16	-	-	HYPH
cord-006229-7yoilsho	1845	17	time	time	NN
cord-006229-7yoilsho	1845	18	monitoring	monitoring	NN
cord-006229-7yoilsho	1845	19	of	of	IN
cord-006229-7yoilsho	1845	20	cGMP	cGMP	NNP
cord-006229-7yoilsho	1845	21	signals	signal	NNS
cord-006229-7yoilsho	1845	22	.	.	.
cord-006229-7yoilsho	1846	1	For	for	IN
cord-006229-7yoilsho	1846	2	example	example	NN
cord-006229-7yoilsho	1846	3	,	,	,
cord-006229-7yoilsho	1846	4	mcGi500	mcGi500	''
cord-006229-7yoilsho	1846	5	would	would	MD
cord-006229-7yoilsho	1846	6	be	be	VB
cord-006229-7yoilsho	1846	7	useful	useful	JJ
cord-006229-7yoilsho	1846	8	to	to	TO
cord-006229-7yoilsho	1846	9	investigate	investigate	VB
cord-006229-7yoilsho	1846	10	membrane	membrane	NN
cord-006229-7yoilsho	1846	11	-	-	HYPH
cord-006229-7yoilsho	1846	12	associated	associate	VBN
cord-006229-7yoilsho	1846	13	cGMP	cGMP	NNP
cord-006229-7yoilsho	1846	14	compartments	compartment	NNS
cord-006229-7yoilsho	1846	15	and	and	CC
cord-006229-7yoilsho	1846	16	red	red	NN
cord-006229-7yoilsho	1846	17	cGi500	cGi500	NNP
cord-006229-7yoilsho	1846	18	to	to	TO
cord-006229-7yoilsho	1846	19	study	study	VB
cord-006229-7yoilsho	1846	20	the	the	DT
cord-006229-7yoilsho	1846	21	crosstalk	crosstalk	NN
cord-006229-7yoilsho	1846	22	between	between	IN
cord-006229-7yoilsho	1846	23	cGMP	cGMP	NNP
cord-006229-7yoilsho	1846	24	and	and	CC
cord-006229-7yoilsho	1846	25	cAMP	camp	NN
cord-006229-7yoilsho	1846	26	signalling	signal	VBG
cord-006229-7yoilsho	1846	27	in	in	IN
cord-006229-7yoilsho	1846	28	living	live	VBG
cord-006229-7yoilsho	1846	29	cells	cell	NNS
cord-006229-7yoilsho	1846	30	and	and	CC
cord-006229-7yoilsho	1846	31	tissues	tissue	NNS
cord-006229-7yoilsho	1846	32	.	.	.
cord-006229-7yoilsho	1847	1	The	the	DT
cord-006229-7yoilsho	1847	2	cGMP	cgmp	JJ
cord-006229-7yoilsho	1847	3	-	-	HYPH
cord-006229-7yoilsho	1847	4	system	system	NN
cord-006229-7yoilsho	1847	5	is	be	VBZ
cord-006229-7yoilsho	1847	6	a	a	DT
cord-006229-7yoilsho	1847	7	major	major	JJ
cord-006229-7yoilsho	1847	8	regulator	regulator	NN
cord-006229-7yoilsho	1847	9	of	of	IN
cord-006229-7yoilsho	1847	10	blood	blood	NN
cord-006229-7yoilsho	1847	11	pressure	pressure	NN
cord-006229-7yoilsho	1847	12	.	.	.
cord-006229-7yoilsho	1848	1	cGMP	cgmp	JJ
cord-006229-7yoilsho	1848	2	-	-	HYPH
cord-006229-7yoilsho	1848	3	dependent	dependent	JJ
cord-006229-7yoilsho	1848	4	protein	protein	NN
cord-006229-7yoilsho	1848	5	kinases	kinase	NNS
cord-006229-7yoilsho	1848	6	(	(	-LRB-
cord-006229-7yoilsho	1848	7	cGKs	cGKs	NNP
cord-006229-7yoilsho	1848	8	)	)	-RRB-
cord-006229-7yoilsho	1848	9	,	,	,
cord-006229-7yoilsho	1848	10	located	locate	VBN
cord-006229-7yoilsho	1848	11	in	in	IN
cord-006229-7yoilsho	1848	12	the	the	DT
cord-006229-7yoilsho	1848	13	smooth	smooth	JJ
cord-006229-7yoilsho	1848	14	muscle	muscle	NN
cord-006229-7yoilsho	1848	15	layer	layer	NN
cord-006229-7yoilsho	1848	16	of	of	IN
cord-006229-7yoilsho	1848	17	vessels	vessel	NNS
cord-006229-7yoilsho	1848	18	,	,	,
cord-006229-7yoilsho	1848	19	enable	enable	VB
cord-006229-7yoilsho	1848	20	cells	cell	NNS
cord-006229-7yoilsho	1848	21	to	to	TO
cord-006229-7yoilsho	1848	22	dilate	dilate	VB
cord-006229-7yoilsho	1848	23	and	and	CC
cord-006229-7yoilsho	1848	24	therefore	therefore	RB
cord-006229-7yoilsho	1848	25	cause	cause	VB
cord-006229-7yoilsho	1848	26	a	a	DT
cord-006229-7yoilsho	1848	27	decrease	decrease	NN
cord-006229-7yoilsho	1848	28	in	in	IN
cord-006229-7yoilsho	1848	29	blood	blood	NN
cord-006229-7yoilsho	1848	30	pressure	pressure	NN
cord-006229-7yoilsho	1848	31	(	(	-LRB-
cord-006229-7yoilsho	1848	32	BP	BP	NNP
cord-006229-7yoilsho	1848	33	)	)	-RRB-
cord-006229-7yoilsho	1848	34	.	.	.
cord-006229-7yoilsho	1849	1	To	to	IN
cord-006229-7yoilsho	1849	2	the	the	DT
cord-006229-7yoilsho	1849	3	contrary	contrary	NN
cord-006229-7yoilsho	1849	4	,	,	,
cord-006229-7yoilsho	1849	5	the	the	DT
cord-006229-7yoilsho	1849	6	reninangiotensin	reninangiotensin	JJ
cord-006229-7yoilsho	1849	7	-	-	HYPH
cord-006229-7yoilsho	1849	8	aldosteron	aldosteron	NN
cord-006229-7yoilsho	1849	9	-	-	HYPH
cord-006229-7yoilsho	1849	10	system	system	NN
cord-006229-7yoilsho	1849	11	(	(	-LRB-
cord-006229-7yoilsho	1849	12	RAAS	RAAS	NNP
cord-006229-7yoilsho	1849	13	)	)	-RRB-
cord-006229-7yoilsho	1849	14	acts	act	VBZ
cord-006229-7yoilsho	1849	15	as	as	IN
cord-006229-7yoilsho	1849	16	opponent	opponent	NN
cord-006229-7yoilsho	1849	17	and	and	CC
cord-006229-7yoilsho	1849	18	causes	cause	VBZ
cord-006229-7yoilsho	1849	19	an	an	DT
cord-006229-7yoilsho	1849	20	increase	increase	NN
cord-006229-7yoilsho	1849	21	in	in	IN
cord-006229-7yoilsho	1849	22	BP	BP	NNP
cord-006229-7yoilsho	1849	23	;	;	:
cord-006229-7yoilsho	1849	24	furthermore	furthermore	RB
cord-006229-7yoilsho	1849	25	,	,	,
cord-006229-7yoilsho	1849	26	it	-PRON-	PRP
cord-006229-7yoilsho	1849	27	influences	influence	VBZ
cord-006229-7yoilsho	1849	28	fluid	fluid	JJ
cord-006229-7yoilsho	1849	29	-	-	HYPH
cord-006229-7yoilsho	1849	30	electrolyte	electrolyte	JJ
cord-006229-7yoilsho	1849	31	balance	balance	NN
cord-006229-7yoilsho	1849	32	.	.	.
cord-006229-7yoilsho	1850	1	Renin	renin	NN
cord-006229-7yoilsho	1850	2	,	,	,
cord-006229-7yoilsho	1850	3	which	which	WDT
cord-006229-7yoilsho	1850	4	is	be	VBZ
cord-006229-7yoilsho	1850	5	secreted	secrete	VBN
cord-006229-7yoilsho	1850	6	from	from	IN
cord-006229-7yoilsho	1850	7	reninproducing	reninproduce	VBG
cord-006229-7yoilsho	1850	8	cells	cell	NNS
cord-006229-7yoilsho	1850	9	located	locate	VBN
cord-006229-7yoilsho	1850	10	in	in	IN
cord-006229-7yoilsho	1850	11	the	the	DT
cord-006229-7yoilsho	1850	12	juxtaglomerular	juxtaglomerular	JJ
cord-006229-7yoilsho	1850	13	apparatus	apparatus	NN
cord-006229-7yoilsho	1850	14	(	(	-LRB-
cord-006229-7yoilsho	1850	15	JGA	JGA	NNP
cord-006229-7yoilsho	1850	16	)	)	-RRB-
cord-006229-7yoilsho	1850	17	,	,	,
cord-006229-7yoilsho	1850	18	is	be	VBZ
cord-006229-7yoilsho	1850	19	the	the	DT
cord-006229-7yoilsho	1850	20	key	key	JJ
cord-006229-7yoilsho	1850	21	regulator	regulator	NN
cord-006229-7yoilsho	1850	22	enzyme	enzyme	NN
cord-006229-7yoilsho	1850	23	in	in	IN
cord-006229-7yoilsho	1850	24	this	this	DT
cord-006229-7yoilsho	1850	25	system	system	NN
cord-006229-7yoilsho	1850	26	.	.	.
cord-006229-7yoilsho	1851	1	Pharmacological	pharmacological	JJ
cord-006229-7yoilsho	1851	2	inhibition	inhibition	NN
cord-006229-7yoilsho	1851	3	of	of	IN
cord-006229-7yoilsho	1851	4	the	the	DT
cord-006229-7yoilsho	1851	5	RAAS	raa	NNS
cord-006229-7yoilsho	1851	6	,	,	,
cord-006229-7yoilsho	1851	7	e.g.	e.g.	RB
cord-006229-7yoilsho	1851	8	via	via	IN
cord-006229-7yoilsho	1851	9	ACE	ace	NN
cord-006229-7yoilsho	1851	10	-	-	HYPH
cord-006229-7yoilsho	1851	11	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	1851	12	or	or	CC
cord-006229-7yoilsho	1851	13	AT1-receptor	at1-receptor	NN
cord-006229-7yoilsho	1851	14	-	-	HYPH
cord-006229-7yoilsho	1851	15	antagonists	antagonist	NNS
cord-006229-7yoilsho	1851	16	,	,	,
cord-006229-7yoilsho	1851	17	is	be	VBZ
cord-006229-7yoilsho	1851	18	a	a	DT
cord-006229-7yoilsho	1851	19	powerful	powerful	JJ
cord-006229-7yoilsho	1851	20	tool	tool	NN
cord-006229-7yoilsho	1851	21	to	to	TO
cord-006229-7yoilsho	1851	22	treat	treat	VB
cord-006229-7yoilsho	1851	23	hypertension	hypertension	NN
cord-006229-7yoilsho	1851	24	,	,	,
cord-006229-7yoilsho	1851	25	but	but	CC
cord-006229-7yoilsho	1851	26	chronically	chronically	RB
cord-006229-7yoilsho	1851	27	challenges	challenge	VBZ
cord-006229-7yoilsho	1851	28	this	this	DT
cord-006229-7yoilsho	1851	29	endocrine	endocrine	NN
cord-006229-7yoilsho	1851	30	system	system	NN
cord-006229-7yoilsho	1851	31	,	,	,
cord-006229-7yoilsho	1851	32	resulting	result	VBG
cord-006229-7yoilsho	1851	33	in	in	IN
cord-006229-7yoilsho	1851	34	an	an	DT
cord-006229-7yoilsho	1851	35	enhancement	enhancement	NN
cord-006229-7yoilsho	1851	36	of	of	IN
cord-006229-7yoilsho	1851	37	renin	renin	NN
cord-006229-7yoilsho	1851	38	expression	expression	NN
cord-006229-7yoilsho	1851	39	.	.	.
cord-006229-7yoilsho	1852	1	This	this	DT
cord-006229-7yoilsho	1852	2	is	be	VBZ
cord-006229-7yoilsho	1852	3	caused	cause	VBN
cord-006229-7yoilsho	1852	4	by	by	IN
cord-006229-7yoilsho	1852	5	an	an	DT
cord-006229-7yoilsho	1852	6	increased	increase	VBN
cord-006229-7yoilsho	1852	7	number	number	NN
cord-006229-7yoilsho	1852	8	of	of	IN
cord-006229-7yoilsho	1852	9	renin	renin	NN
cord-006229-7yoilsho	1852	10	-	-	HYPH
cord-006229-7yoilsho	1852	11	expressing	express	VBG
cord-006229-7yoilsho	1852	12	cells	cell	NNS
cord-006229-7yoilsho	1852	13	(	(	-LRB-
cord-006229-7yoilsho	1852	14	the	the	DT
cord-006229-7yoilsho	1852	15	so	so	RB
cord-006229-7yoilsho	1852	16	-	-	HYPH
cord-006229-7yoilsho	1852	17	called	call	VBN
cord-006229-7yoilsho	1852	18	reninrecruitment	reninrecruitment	NN
cord-006229-7yoilsho	1852	19	)	)	-RRB-
cord-006229-7yoilsho	1852	20	,	,	,
cord-006229-7yoilsho	1852	21	which	which	WDT
cord-006229-7yoilsho	1852	22	derive	derive	VBP
cord-006229-7yoilsho	1852	23	from	from	IN
cord-006229-7yoilsho	1852	24	a	a	DT
cord-006229-7yoilsho	1852	25	reversible	reversible	JJ
cord-006229-7yoilsho	1852	26	metaplastic	metaplastic	JJ
cord-006229-7yoilsho	1852	27	retransformation	retransformation	NN
cord-006229-7yoilsho	1852	28	of	of	IN
cord-006229-7yoilsho	1852	29	extraglomerular	extraglomerular	JJ
cord-006229-7yoilsho	1852	30	and	and	CC
cord-006229-7yoilsho	1852	31	smooth	smooth	JJ
cord-006229-7yoilsho	1852	32	muscle	muscle	NN
cord-006229-7yoilsho	1852	33	cells	cell	NNS
cord-006229-7yoilsho	1852	34	of	of	IN
cord-006229-7yoilsho	1852	35	afferent	afferent	JJ
cord-006229-7yoilsho	1852	36	arterioles	arteriole	NNS
cord-006229-7yoilsho	1852	37	.	.	.
cord-006229-7yoilsho	1853	1	Next	next	RB
cord-006229-7yoilsho	1853	2	to	to	IN
cord-006229-7yoilsho	1853	3	regulation	regulation	NN
cord-006229-7yoilsho	1853	4	of	of	IN
cord-006229-7yoilsho	1853	5	renin	renin	NN
cord-006229-7yoilsho	1853	6	-	-	HYPH
cord-006229-7yoilsho	1853	7	function	function	NN
cord-006229-7yoilsho	1853	8	via	via	IN
cord-006229-7yoilsho	1853	9	cAMP	camp	NN
cord-006229-7yoilsho	1853	10	/	/	SYM
cord-006229-7yoilsho	1853	11	PKA	PKA	NNP
cord-006229-7yoilsho	1853	12	,	,	,
cord-006229-7yoilsho	1853	13	it	-PRON-	PRP
cord-006229-7yoilsho	1853	14	has	have	VBZ
cord-006229-7yoilsho	1853	15	been	be	VBN
cord-006229-7yoilsho	1853	16	shown	show	VBN
cord-006229-7yoilsho	1853	17	that	that	IN
cord-006229-7yoilsho	1853	18	eNOS	enos	RB
cord-006229-7yoilsho	1853	19	-	-	HYPH
cord-006229-7yoilsho	1853	20	derived	derive	VBN
cord-006229-7yoilsho	1853	21	NO	NO	NNP
cord-006229-7yoilsho	1853	22	supports	support	VBZ
cord-006229-7yoilsho	1853	23	this	this	DT
cord-006229-7yoilsho	1853	24	recruitment	recruitment	NN
cord-006229-7yoilsho	1853	25	via	via	IN
cord-006229-7yoilsho	1853	26	activation	activation	NN
cord-006229-7yoilsho	1853	27	of	of	IN
cord-006229-7yoilsho	1853	28	sGC	sGC	NNS
cord-006229-7yoilsho	1853	29	and	and	CC
cord-006229-7yoilsho	1853	30	subsequent	subsequent	JJ
cord-006229-7yoilsho	1853	31	generation	generation	NN
cord-006229-7yoilsho	1853	32	of	of	IN
cord-006229-7yoilsho	1853	33	cGMP	cGMP	NNP
cord-006229-7yoilsho	1853	34	[	[	-LRB-
cord-006229-7yoilsho	1853	35	1	1	CD
cord-006229-7yoilsho	1853	36	]	]	-RRB-
cord-006229-7yoilsho	1853	37	.	.	.
cord-006229-7yoilsho	1854	1	Whether	whether	IN
cord-006229-7yoilsho	1854	2	this	this	DT
cord-006229-7yoilsho	1854	3	causes	cause	VBZ
cord-006229-7yoilsho	1854	4	an	an	DT
cord-006229-7yoilsho	1854	5	activation	activation	NN
cord-006229-7yoilsho	1854	6	of	of	IN
cord-006229-7yoilsho	1854	7	cGKs	cgk	NNS
cord-006229-7yoilsho	1854	8	is	be	VBZ
cord-006229-7yoilsho	1854	9	not	not	RB
cord-006229-7yoilsho	1854	10	known	know	VBN
cord-006229-7yoilsho	1854	11	.	.	.
cord-006229-7yoilsho	1855	1	These	these	DT
cord-006229-7yoilsho	1855	2	enzymes	enzyme	NNS
cord-006229-7yoilsho	1855	3	exist	exist	VBP
cord-006229-7yoilsho	1855	4	in	in	IN
cord-006229-7yoilsho	1855	5	3	3	CD
cord-006229-7yoilsho	1855	6	different	different	JJ
cord-006229-7yoilsho	1855	7	isoforms	isoform	NNS
cord-006229-7yoilsho	1855	8	,	,	,
cord-006229-7yoilsho	1855	9	cGKIα	cGKIα	NNS
cord-006229-7yoilsho	1855	10	,	,	,
cord-006229-7yoilsho	1855	11	cGKIβ	cGKIβ	NNS
cord-006229-7yoilsho	1855	12	und	und	IN
cord-006229-7yoilsho	1855	13	cGKII	cgkii	NN
cord-006229-7yoilsho	1855	14	.	.	.
cord-006229-7yoilsho	1856	1	In	in	IN
cord-006229-7yoilsho	1856	2	contrast	contrast	NN
cord-006229-7yoilsho	1856	3	to	to	IN
cord-006229-7yoilsho	1856	4	the	the	DT
cord-006229-7yoilsho	1856	5	β	β	NN
cord-006229-7yoilsho	1856	6	-	-	HYPH
cord-006229-7yoilsho	1856	7	isoform	isoform	NN
cord-006229-7yoilsho	1856	8	,	,	,
cord-006229-7yoilsho	1856	9	cGKIα	cGKIα	''
cord-006229-7yoilsho	1856	10	(	(	-LRB-
cord-006229-7yoilsho	1856	11	as	as	RB
cord-006229-7yoilsho	1856	12	well	well	RB
cord-006229-7yoilsho	1856	13	as	as	IN
cord-006229-7yoilsho	1856	14	cGKII	cgkii	NN
cord-006229-7yoilsho	1856	15	)	)	-RRB-
cord-006229-7yoilsho	1856	16	is	be	VBZ
cord-006229-7yoilsho	1856	17	highly	highly	RB
cord-006229-7yoilsho	1856	18	expressed	express	VBN
cord-006229-7yoilsho	1856	19	in	in	IN
cord-006229-7yoilsho	1856	20	the	the	DT
cord-006229-7yoilsho	1856	21	JGA	JGA	NNP
cord-006229-7yoilsho	1856	22	[	[	-LRB-
cord-006229-7yoilsho	1856	23	2	2	CD
cord-006229-7yoilsho	1856	24	]	]	-RRB-
cord-006229-7yoilsho	1856	25	,	,	,
cord-006229-7yoilsho	1856	26	[	[	-LRB-
cord-006229-7yoilsho	1856	27	3	3	CD
cord-006229-7yoilsho	1856	28	]	]	-RRB-
cord-006229-7yoilsho	1856	29	.	.	.
cord-006229-7yoilsho	1857	1	Therefore	therefore	RB
cord-006229-7yoilsho	1857	2	,	,	,
cord-006229-7yoilsho	1857	3	we	-PRON-	PRP
cord-006229-7yoilsho	1857	4	analyzed	analyze	VBD
cord-006229-7yoilsho	1857	5	,	,	,
cord-006229-7yoilsho	1857	6	whether	whether	IN
cord-006229-7yoilsho	1857	7	cGKIα	cGKIα	``
cord-006229-7yoilsho	1857	8	also	also	RB
cord-006229-7yoilsho	1857	9	plays	play	VBZ
cord-006229-7yoilsho	1857	10	a	a	DT
cord-006229-7yoilsho	1857	11	role	role	NN
cord-006229-7yoilsho	1857	12	regarding	regard	VBG
cord-006229-7yoilsho	1857	13	renin	renin	NN
cord-006229-7yoilsho	1857	14	synthesis	synthesis	NN
cord-006229-7yoilsho	1857	15	,	,	,
cord-006229-7yoilsho	1857	16	secretion	secretion	NN
cord-006229-7yoilsho	1857	17	or	or	CC
cord-006229-7yoilsho	1857	18	recruitment	recruitment	NN
cord-006229-7yoilsho	1857	19	.	.	.
cord-006229-7yoilsho	1858	1	To	to	TO
cord-006229-7yoilsho	1858	2	characterize	characterize	VB
cord-006229-7yoilsho	1858	3	the	the	DT
cord-006229-7yoilsho	1858	4	function	function	NN
cord-006229-7yoilsho	1858	5	of	of	IN
cord-006229-7yoilsho	1858	6	cGKIα	cGKIα	NNS
cord-006229-7yoilsho	1858	7	in	in	IN
cord-006229-7yoilsho	1858	8	JGA	JGA	NNP
cord-006229-7yoilsho	1858	9	-	-	HYPH
cord-006229-7yoilsho	1858	10	cells	cell	NNS
cord-006229-7yoilsho	1858	11	,	,	,
cord-006229-7yoilsho	1858	12	we	-PRON-	PRP
cord-006229-7yoilsho	1858	13	generated	generate	VBD
cord-006229-7yoilsho	1858	14	renin	renin	NN
cord-006229-7yoilsho	1858	15	-	-	HYPH
cord-006229-7yoilsho	1858	16	cell	cell	NN
cord-006229-7yoilsho	1858	17	specific	specific	JJ
cord-006229-7yoilsho	1858	18	cGKIα	cgkiα	CD
cord-006229-7yoilsho	1858	19	-	-	HYPH
cord-006229-7yoilsho	1858	20	knockout	knockout	NN
cord-006229-7yoilsho	1858	21	mice	mouse	NNS
cord-006229-7yoilsho	1859	1	(	(	-LRB-
cord-006229-7yoilsho	1859	2	Ren	Ren	NNP
cord-006229-7yoilsho	1859	3	Cre	Cre	NNP
cord-006229-7yoilsho	1859	4	-	-	HYPH
cord-006229-7yoilsho	1859	5	cGKI	cGKI	NNP
cord-006229-7yoilsho	1859	6	fl	fl	NNP
cord-006229-7yoilsho	1859	7	/	/	SYM
cord-006229-7yoilsho	1859	8	fl	fl	NNP
cord-006229-7yoilsho	1859	9	)	)	-RRB-
cord-006229-7yoilsho	1859	10	and	and	CC
cord-006229-7yoilsho	1859	11	stimulated	stimulate	VBD
cord-006229-7yoilsho	1859	12	renin	renin	NN
cord-006229-7yoilsho	1859	13	recruitment	recruitment	NN
cord-006229-7yoilsho	1859	14	via	via	IN
cord-006229-7yoilsho	1859	15	administration	administration	NN
cord-006229-7yoilsho	1859	16	of	of	IN
cord-006229-7yoilsho	1859	17	a	a	DT
cord-006229-7yoilsho	1859	18	low	low	JJ
cord-006229-7yoilsho	1859	19	salt	salt	NN
cord-006229-7yoilsho	1859	20	diet	diet	NN
cord-006229-7yoilsho	1859	21	(	(	-LRB-
cord-006229-7yoilsho	1860	1	0.02	0.02	CD
cord-006229-7yoilsho	1860	2	%	%	NN
cord-006229-7yoilsho	1860	3	Na	Na	NNP
cord-006229-7yoilsho	1860	4	+	+	CC
cord-006229-7yoilsho	1860	5	)	)	-RRB-
cord-006229-7yoilsho	1860	6	and	and	CC
cord-006229-7yoilsho	1860	7	enalapril	enalapril	NNP
cord-006229-7yoilsho	1860	8	(	(	-LRB-
cord-006229-7yoilsho	1860	9	10mg	10mg	NNP
cord-006229-7yoilsho	1860	10	/	/	SYM
cord-006229-7yoilsho	1860	11	kg	kg	NN
cord-006229-7yoilsho	1860	12	/	/	SYM
cord-006229-7yoilsho	1860	13	d	d	NN
cord-006229-7yoilsho	1860	14	)	)	-RRB-
cord-006229-7yoilsho	1860	15	for	for	IN
cord-006229-7yoilsho	1860	16	3	3	CD
cord-006229-7yoilsho	1860	17	weeks	week	NNS
cord-006229-7yoilsho	1860	18	.	.	.
cord-006229-7yoilsho	1861	1	We	-PRON-	PRP
cord-006229-7yoilsho	1861	2	analyzed	analyze	VBD
cord-006229-7yoilsho	1861	3	blood	blood	NN
cord-006229-7yoilsho	1861	4	pressure	pressure	NN
cord-006229-7yoilsho	1861	5	,	,	,
cord-006229-7yoilsho	1861	6	mRNA	mrna	NN
cord-006229-7yoilsho	1861	7	and	and	CC
cord-006229-7yoilsho	1861	8	renal	renal	JJ
cord-006229-7yoilsho	1861	9	protein	protein	NN
cord-006229-7yoilsho	1861	10	content	content	NN
cord-006229-7yoilsho	1861	11	of	of	IN
cord-006229-7yoilsho	1861	12	renin	renin	NN
cord-006229-7yoilsho	1861	13	and	and	CC
cord-006229-7yoilsho	1861	14	cGKIα	cGKIα	NNS
cord-006229-7yoilsho	1861	15	,	,	,
cord-006229-7yoilsho	1861	16	plasma	plasma	NN
cord-006229-7yoilsho	1861	17	renin	renin	NN
cord-006229-7yoilsho	1861	18	activity	activity	NN
cord-006229-7yoilsho	1861	19	and	and	CC
cord-006229-7yoilsho	1861	20	renin	renin	NN
cord-006229-7yoilsho	1861	21	recruitment	recruitment	NN
cord-006229-7yoilsho	1861	22	.	.	.
cord-006229-7yoilsho	1862	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	1862	2	,	,	,
cord-006229-7yoilsho	1862	3	we	-PRON-	PRP
cord-006229-7yoilsho	1862	4	activated	activate	VBD
cord-006229-7yoilsho	1862	5	the	the	DT
cord-006229-7yoilsho	1862	6	cGMP	cgmp	JJ
cord-006229-7yoilsho	1862	7	-	-	HYPH
cord-006229-7yoilsho	1862	8	system	system	NN
cord-006229-7yoilsho	1862	9	in	in	IN
cord-006229-7yoilsho	1862	10	these	these	DT
cord-006229-7yoilsho	1862	11	mice	mouse	NNS
cord-006229-7yoilsho	1862	12	using	use	VBG
cord-006229-7yoilsho	1862	13	BAY41	BAY41	NNP
cord-006229-7yoilsho	1862	14	-	-	HYPH
cord-006229-7yoilsho	1862	15	8543	8543	CD
cord-006229-7yoilsho	1862	16	,	,	,
cord-006229-7yoilsho	1862	17	a	a	DT
cord-006229-7yoilsho	1862	18	sGCstimulator	sgcstimulator	NN
cord-006229-7yoilsho	1862	19	,	,	,
cord-006229-7yoilsho	1862	20	and	and	CC
cord-006229-7yoilsho	1862	21	re	re	VBN
cord-006229-7yoilsho	1862	22	-	-	VBN
cord-006229-7yoilsho	1862	23	analyzed	analyze	VBD
cord-006229-7yoilsho	1862	24	the	the	DT
cord-006229-7yoilsho	1862	25	above	above	RB
cord-006229-7yoilsho	1862	26	-	-	HYPH
cord-006229-7yoilsho	1862	27	mentioned	mention	VBN
cord-006229-7yoilsho	1862	28	parameters	parameter	NNS
cord-006229-7yoilsho	1862	29	.	.	.
cord-006229-7yoilsho	1863	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	1863	2	results	result	NNS
cord-006229-7yoilsho	1863	3	indicate	indicate	VBP
cord-006229-7yoilsho	1863	4	that	that	IN
cord-006229-7yoilsho	1863	5	cGKIα	cGKIα	NNS
cord-006229-7yoilsho	1863	6	could	could	MD
cord-006229-7yoilsho	1863	7	be	be	VB
cord-006229-7yoilsho	1863	8	an	an	DT
cord-006229-7yoilsho	1863	9	additional	additional	JJ
cord-006229-7yoilsho	1863	10	system	system	NN
cord-006229-7yoilsho	1863	11	supporting	support	VBG
cord-006229-7yoilsho	1863	12	renin	renin	NN
cord-006229-7yoilsho	1863	13	recruitment	recruitment	NN
cord-006229-7yoilsho	1863	14	but	but	CC
cord-006229-7yoilsho	1863	15	is	be	VBZ
cord-006229-7yoilsho	1863	16	not	not	RB
cord-006229-7yoilsho	1863	17	a	a	DT
cord-006229-7yoilsho	1863	18	crucial	crucial	JJ
cord-006229-7yoilsho	1863	19	pre	pre	JJ
cord-006229-7yoilsho	1863	20	-	-	JJ
cord-006229-7yoilsho	1863	21	requisite	requisite	JJ
cord-006229-7yoilsho	1863	22	.	.	.
cord-006229-7yoilsho	1864	1	In	in	IN
cord-006229-7yoilsho	1864	2	contrast	contrast	NN
cord-006229-7yoilsho	1864	3	,	,	,
cord-006229-7yoilsho	1864	4	the	the	DT
cord-006229-7yoilsho	1864	5	basal	basal	NN
cord-006229-7yoilsho	1864	6	renin	renin	NN
cord-006229-7yoilsho	1864	7	concentration	concentration	NN
cord-006229-7yoilsho	1864	8	and	and	CC
cord-006229-7yoilsho	1864	9	activity	activity	NN
cord-006229-7yoilsho	1864	10	appears	appear	VBZ
cord-006229-7yoilsho	1864	11	to	to	TO
cord-006229-7yoilsho	1864	12	be	be	VB
cord-006229-7yoilsho	1864	13	downregulated	downregulate	VBN
cord-006229-7yoilsho	1864	14	in	in	IN
cord-006229-7yoilsho	1864	15	Ren	Ren	NNP
cord-006229-7yoilsho	1864	16	Cre	Cre	NNP
cord-006229-7yoilsho	1864	17	-	-	HYPH
cord-006229-7yoilsho	1864	18	cGKI	cGKI	NNP
cord-006229-7yoilsho	1864	19	fl	fl	NNP
cord-006229-7yoilsho	1864	20	/	/	SYM
cord-006229-7yoilsho	1864	21	fl	fl	NNP
cord-006229-7yoilsho	1864	22	-	-	HYPH
cord-006229-7yoilsho	1864	23	mice	mouse	NNS
cord-006229-7yoilsho	1864	24	,	,	,
cord-006229-7yoilsho	1864	25	thus	thus	RB
cord-006229-7yoilsho	1864	26	,	,	,
cord-006229-7yoilsho	1864	27	cGKI	cGKI	NNP
cord-006229-7yoilsho	1864	28	could	could	MD
cord-006229-7yoilsho	1864	29	be	be	VB
cord-006229-7yoilsho	1864	30	an	an	DT
cord-006229-7yoilsho	1864	31	important	important	JJ
cord-006229-7yoilsho	1864	32	regulator	regulator	NN
cord-006229-7yoilsho	1864	33	of	of	IN
cord-006229-7yoilsho	1864	34	renin	renin	NN
cord-006229-7yoilsho	1864	35	synthesis	synthesis	NN
cord-006229-7yoilsho	1864	36	.	.	.
cord-006229-7yoilsho	1865	1	Universität	Universität	NNP
cord-006229-7yoilsho	1865	2	Regensburg	Regensburg	NNP
cord-006229-7yoilsho	1865	3	,	,	,
cord-006229-7yoilsho	1865	4	Pharmakologie	Pharmakologie	NNP
cord-006229-7yoilsho	1865	5	und	und	XX
cord-006229-7yoilsho	1866	1	Toxikologie	Toxikologie	NNP
cord-006229-7yoilsho	1866	2	,	,	,
cord-006229-7yoilsho	1866	3	Regensburg	Regensburg	NNP
cord-006229-7yoilsho	1866	4	,	,	,
cord-006229-7yoilsho	1866	5	Germany	Germany	NNP
cord-006229-7yoilsho	1866	6	Jaw1	Jaw1	NNP
cord-006229-7yoilsho	1866	7	/	/	SYM
cord-006229-7yoilsho	1866	8	Lrmp	Lrmp	NNP
cord-006229-7yoilsho	1866	9	(	(	-LRB-
cord-006229-7yoilsho	1866	10	lymphoid	lymphoid	NN
cord-006229-7yoilsho	1866	11	-	-	HYPH
cord-006229-7yoilsho	1866	12	restricted	restrict	VBN
cord-006229-7yoilsho	1866	13	membrane	membrane	NN
cord-006229-7yoilsho	1866	14	protein	protein	NN
cord-006229-7yoilsho	1866	15	)	)	-RRB-
cord-006229-7yoilsho	1866	16	is	be	VBZ
cord-006229-7yoilsho	1866	17	a	a	DT
cord-006229-7yoilsho	1866	18	type	type	NN
cord-006229-7yoilsho	1866	19	2	2	CD
cord-006229-7yoilsho	1866	20	membrane	membrane	NN
cord-006229-7yoilsho	1866	21	protein	protein	NN
cord-006229-7yoilsho	1866	22	,	,	,
cord-006229-7yoilsho	1866	23	localised	localise	VBN
cord-006229-7yoilsho	1866	24	to	to	IN
cord-006229-7yoilsho	1866	25	the	the	DT
cord-006229-7yoilsho	1866	26	cytoplasmic	cytoplasmic	JJ
cord-006229-7yoilsho	1866	27	face	face	NN
cord-006229-7yoilsho	1866	28	of	of	IN
cord-006229-7yoilsho	1866	29	the	the	DT
cord-006229-7yoilsho	1866	30	endoplasmic	endoplasmic	NN
cord-006229-7yoilsho	1866	31	reticulum	reticulum	NN
cord-006229-7yoilsho	1866	32	.	.	.
cord-006229-7yoilsho	1867	1	It	-PRON-	PRP
cord-006229-7yoilsho	1867	2	encodes	encode	VBZ
cord-006229-7yoilsho	1867	3	a	a	DT
cord-006229-7yoilsho	1867	4	539	539	CD
cord-006229-7yoilsho	1867	5	amino	amino	NN
cord-006229-7yoilsho	1867	6	acid	acid	NN
cord-006229-7yoilsho	1867	7	protein	protein	NN
cord-006229-7yoilsho	1867	8	with	with	IN
cord-006229-7yoilsho	1867	9	a	a	DT
cord-006229-7yoilsho	1867	10	highly	highly	RB
cord-006229-7yoilsho	1867	11	conserved	conserved	JJ
cord-006229-7yoilsho	1867	12	coiled	coil	VBN
cord-006229-7yoilsho	1867	13	-	-	HYPH
cord-006229-7yoilsho	1867	14	coil	coil	NN
cord-006229-7yoilsho	1867	15	domain	domain	NN
cord-006229-7yoilsho	1867	16	in	in	IN
cord-006229-7yoilsho	1867	17	the	the	DT
cord-006229-7yoilsho	1867	18	middle	middle	JJ
cord-006229-7yoilsho	1867	19	third	third	JJ
cord-006229-7yoilsho	1867	20	of	of	IN
cord-006229-7yoilsho	1867	21	the	the	DT
cord-006229-7yoilsho	1867	22	protein	protein	NN
cord-006229-7yoilsho	1867	23	and	and	CC
cord-006229-7yoilsho	1867	24	a	a	DT
cord-006229-7yoilsho	1867	25	COOH	COOH	NNP
cord-006229-7yoilsho	1867	26	-	-	HYPH
cord-006229-7yoilsho	1867	27	terminal	terminal	NN
cord-006229-7yoilsho	1867	28	transmembrane	transmembrane	NN
cord-006229-7yoilsho	1867	29	domain	domain	NN
cord-006229-7yoilsho	1867	30	[	[	-LRB-
cord-006229-7yoilsho	1867	31	1	1	CD
cord-006229-7yoilsho	1867	32	]	]	-RRB-
cord-006229-7yoilsho	1867	33	,	,	,
cord-006229-7yoilsho	1867	34	[	[	-LRB-
cord-006229-7yoilsho	1867	35	2	2	CD
cord-006229-7yoilsho	1867	36	]	]	-RRB-
cord-006229-7yoilsho	1867	37	.	.	.
cord-006229-7yoilsho	1868	1	Jaw1	Jaw1	NNP
cord-006229-7yoilsho	1868	2	and	and	CC
cord-006229-7yoilsho	1868	3	IRAG	IRAG	NNP
cord-006229-7yoilsho	1868	4	have	have	VBP
cord-006229-7yoilsho	1868	5	a	a	DT
cord-006229-7yoilsho	1868	6	limited	limited	JJ
cord-006229-7yoilsho	1868	7	homology	homology	NN
cord-006229-7yoilsho	1868	8	throughout	throughout	IN
cord-006229-7yoilsho	1868	9	the	the	DT
cord-006229-7yoilsho	1868	10	length	length	NN
cord-006229-7yoilsho	1868	11	of	of	IN
cord-006229-7yoilsho	1868	12	the	the	DT
cord-006229-7yoilsho	1868	13	protein	protein	NN
cord-006229-7yoilsho	1868	14	.	.	.
cord-006229-7yoilsho	1869	1	The	the	DT
cord-006229-7yoilsho	1869	2	coiled	coiled	JJ
cord-006229-7yoilsho	1869	3	-	-	HYPH
cord-006229-7yoilsho	1869	4	coil	coil	NN
cord-006229-7yoilsho	1869	5	domain	domain	NN
cord-006229-7yoilsho	1869	6	and	and	CC
cord-006229-7yoilsho	1869	7	the	the	DT
cord-006229-7yoilsho	1869	8	putative	putative	JJ
cord-006229-7yoilsho	1869	9	transmembrane	transmembrane	NN
cord-006229-7yoilsho	1869	10	anchor	anchor	NN
cord-006229-7yoilsho	1869	11	at	at	IN
cord-006229-7yoilsho	1869	12	the	the	DT
cord-006229-7yoilsho	1869	13	C	C	NNP
cord-006229-7yoilsho	1869	14	-	-	HYPH
cord-006229-7yoilsho	1869	15	terminus	terminus	NN
cord-006229-7yoilsho	1869	16	of	of	IN
cord-006229-7yoilsho	1869	17	Jaw1	Jaw1	NNP
cord-006229-7yoilsho	1869	18	and	and	CC
cord-006229-7yoilsho	1869	19	IRAG	IRAG	NNP
cord-006229-7yoilsho	1869	20	share	share	VBP
cord-006229-7yoilsho	1869	21	the	the	DT
cord-006229-7yoilsho	1869	22	highest	high	JJS
cord-006229-7yoilsho	1869	23	homology	homology	NN
cord-006229-7yoilsho	1869	24	[	[	-LRB-
cord-006229-7yoilsho	1869	25	3	3	CD
cord-006229-7yoilsho	1869	26	]	]	-RRB-
cord-006229-7yoilsho	1869	27	,	,	,
cord-006229-7yoilsho	1869	28	[	[	-LRB-
cord-006229-7yoilsho	1869	29	4	4	CD
cord-006229-7yoilsho	1869	30	]	]	-RRB-
cord-006229-7yoilsho	1869	31	.	.	.
cord-006229-7yoilsho	1870	1	The	the	DT
cord-006229-7yoilsho	1870	2	coiled	coiled	JJ
cord-006229-7yoilsho	1870	3	coil	coil	NN
cord-006229-7yoilsho	1870	4	domains	domain	NNS
cord-006229-7yoilsho	1870	5	of	of	IN
cord-006229-7yoilsho	1870	6	IRAG	IRAG	NNP
cord-006229-7yoilsho	1870	7	and	and	CC
cord-006229-7yoilsho	1870	8	Jaw1	Jaw1	NNP
cord-006229-7yoilsho	1870	9	are	be	VBP
cord-006229-7yoilsho	1870	10	important	important	JJ
cord-006229-7yoilsho	1870	11	for	for	IN
cord-006229-7yoilsho	1870	12	the	the	DT
cord-006229-7yoilsho	1870	13	interaction	interaction	NN
cord-006229-7yoilsho	1870	14	with	with	IN
cord-006229-7yoilsho	1870	15	IP	ip	NN
cord-006229-7yoilsho	1870	16	3	3	CD
cord-006229-7yoilsho	1870	17	Rs	r	NNS
cord-006229-7yoilsho	1870	18	.	.	.
cord-006229-7yoilsho	1871	1	As	as	IN
cord-006229-7yoilsho	1871	2	already	already	RB
cord-006229-7yoilsho	1871	3	known	know	VBN
cord-006229-7yoilsho	1871	4	,	,	,
cord-006229-7yoilsho	1871	5	IRAG	IRAG	NNP
cord-006229-7yoilsho	1871	6	forms	form	VBZ
cord-006229-7yoilsho	1871	7	a	a	DT
cord-006229-7yoilsho	1871	8	trimeric	trimeric	RB
cord-006229-7yoilsho	1871	9	complex	complex	JJ
cord-006229-7yoilsho	1871	10	with	with	IN
cord-006229-7yoilsho	1871	11	cGKIβ	cGKIβ	NNS
cord-006229-7yoilsho	1871	12	and	and	CC
cord-006229-7yoilsho	1871	13	IP	IP	NNP
cord-006229-7yoilsho	1871	14	3	3	CD
cord-006229-7yoilsho	1871	15	R1	r1	NN
cord-006229-7yoilsho	1871	16	and	and	CC
cord-006229-7yoilsho	1871	17	gets	get	VBZ
cord-006229-7yoilsho	1871	18	phosphorylated	phosphorylate	VBN
cord-006229-7yoilsho	1871	19	by	by	IN
cord-006229-7yoilsho	1871	20	cGKIβ	cGKIβ	NNS
cord-006229-7yoilsho	1871	21	[	[	-LRB-
cord-006229-7yoilsho	1871	22	5	5	CD
cord-006229-7yoilsho	1871	23	]	]	-RRB-
cord-006229-7yoilsho	1871	24	.	.	.
cord-006229-7yoilsho	1872	1	Hence	hence	RB
cord-006229-7yoilsho	1872	2	we	-PRON-	PRP
cord-006229-7yoilsho	1872	3	examined	examine	VBD
cord-006229-7yoilsho	1872	4	if	if	IN
cord-006229-7yoilsho	1872	5	Jaw1	Jaw1	NNP
cord-006229-7yoilsho	1872	6	is	be	VBZ
cord-006229-7yoilsho	1872	7	a	a	DT
cord-006229-7yoilsho	1872	8	new	new	JJ
cord-006229-7yoilsho	1872	9	target	target	NN
cord-006229-7yoilsho	1872	10	protein	protein	NN
cord-006229-7yoilsho	1872	11	of	of	IN
cord-006229-7yoilsho	1872	12	cGKIβ	cGKIβ	NNS
cord-006229-7yoilsho	1872	13	.	.	.
cord-006229-7yoilsho	1873	1	The	the	DT
cord-006229-7yoilsho	1873	2	recognition	recognition	NN
cord-006229-7yoilsho	1873	3	site	site	NN
cord-006229-7yoilsho	1873	4	,	,	,
cord-006229-7yoilsho	1873	5	where	where	WRB
cord-006229-7yoilsho	1873	6	a	a	DT
cord-006229-7yoilsho	1873	7	substrate	substrate	NN
cord-006229-7yoilsho	1873	8	can	can	MD
cord-006229-7yoilsho	1873	9	be	be	VB
cord-006229-7yoilsho	1873	10	phosphorylated	phosphorylate	VBN
cord-006229-7yoilsho	1873	11	by	by	IN
cord-006229-7yoilsho	1873	12	cGKI	cGKI	NNP
cord-006229-7yoilsho	1873	13	,	,	,
cord-006229-7yoilsho	1873	14	is	be	VBZ
cord-006229-7yoilsho	1873	15	composed	compose	VBN
cord-006229-7yoilsho	1873	16	of	of	IN
cord-006229-7yoilsho	1873	17	the	the	DT
cord-006229-7yoilsho	1873	18	following	follow	VBG
cord-006229-7yoilsho	1873	19	amino	amino	NN
cord-006229-7yoilsho	1873	20	acids	acid	NNS
cord-006229-7yoilsho	1873	21	:	:	:
cord-006229-7yoilsho	1874	1	(	(	-LRB-
cord-006229-7yoilsho	1874	2	K	K	NNP
cord-006229-7yoilsho	1874	3	/	/	SYM
cord-006229-7yoilsho	1874	4	R)(K	R)(K	NNP
cord-006229-7yoilsho	1874	5	/	/	SYM
cord-006229-7yoilsho	1874	6	R)X(S	R)X(S	NNP
cord-006229-7yoilsho	1874	7	/	/	SYM
cord-006229-7yoilsho	1874	8	T	T	NNP
cord-006229-7yoilsho	1874	9	)	)	-RRB-
cord-006229-7yoilsho	1874	10	.	.	.
cord-006229-7yoilsho	1875	1	In	in	IN
cord-006229-7yoilsho	1875	2	the	the	DT
cord-006229-7yoilsho	1875	3	amino	amino	NN
cord-006229-7yoilsho	1875	4	acid	acid	NN
cord-006229-7yoilsho	1875	5	sequence	sequence	NN
cord-006229-7yoilsho	1875	6	of	of	IN
cord-006229-7yoilsho	1875	7	Jaw1	Jaw1	NNP
cord-006229-7yoilsho	1875	8	possible	possible	JJ
cord-006229-7yoilsho	1875	9	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	1875	10	sites	site	NNS
cord-006229-7yoilsho	1875	11	can	can	MD
cord-006229-7yoilsho	1875	12	be	be	VB
cord-006229-7yoilsho	1875	13	found	find	VBN
cord-006229-7yoilsho	1875	14	.	.	.
cord-006229-7yoilsho	1876	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	1876	2	in	in	FW
cord-006229-7yoilsho	1876	3	vitro	vitro	FW
cord-006229-7yoilsho	1876	4	studies	study	NNS
cord-006229-7yoilsho	1876	5	with	with	IN
cord-006229-7yoilsho	1876	6	Jaw1	Jaw1	NNP
cord-006229-7yoilsho	1876	7	and	and	CC
cord-006229-7yoilsho	1876	8	cGKI	cGKI	NNP
cord-006229-7yoilsho	1876	9	showed	show	VBD
cord-006229-7yoilsho	1876	10	that	that	IN
cord-006229-7yoilsho	1876	11	Jaw1	Jaw1	NNP
cord-006229-7yoilsho	1876	12	gets	get	VBZ
cord-006229-7yoilsho	1876	13	phosphorylated	phosphorylate	VBN
cord-006229-7yoilsho	1876	14	in	in	IN
cord-006229-7yoilsho	1876	15	a	a	DT
cord-006229-7yoilsho	1876	16	cGMP	cgmp	JJ
cord-006229-7yoilsho	1876	17	-	-	HYPH
cord-006229-7yoilsho	1876	18	dependent	dependent	JJ
cord-006229-7yoilsho	1876	19	manner	manner	NN
cord-006229-7yoilsho	1876	20	by	by	IN
cord-006229-7yoilsho	1876	21	cGKIβ	cGKIβ	NNS
cord-006229-7yoilsho	1876	22	.	.	.
cord-006229-7yoilsho	1877	1	In	in	IN
cord-006229-7yoilsho	1877	2	contrast	contrast	NN
cord-006229-7yoilsho	1877	3	,	,	,
cord-006229-7yoilsho	1877	4	Jaw1	Jaw1	NNP
cord-006229-7yoilsho	1877	5	was	be	VBD
cord-006229-7yoilsho	1877	6	not	not	RB
cord-006229-7yoilsho	1877	7	phosphorylated	phosphorylate	VBN
cord-006229-7yoilsho	1877	8	by	by	IN
cord-006229-7yoilsho	1877	9	cGKIα	cGKIα	NNS
cord-006229-7yoilsho	1877	10	.	.	.
cord-006229-7yoilsho	1878	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	1878	2	,	,	,
cord-006229-7yoilsho	1878	3	no	no	DT
cord-006229-7yoilsho	1878	4	stable	stable	JJ
cord-006229-7yoilsho	1878	5	interaction	interaction	NN
cord-006229-7yoilsho	1878	6	between	between	IN
cord-006229-7yoilsho	1878	7	Jaw1	Jaw1	NNP
cord-006229-7yoilsho	1878	8	and	and	CC
cord-006229-7yoilsho	1878	9	cGKIβ	cGKIβ	NNPS
cord-006229-7yoilsho	1878	10	was	be	VBD
cord-006229-7yoilsho	1878	11	detected	detect	VBN
cord-006229-7yoilsho	1878	12	.	.	.
cord-006229-7yoilsho	1879	1	To	to	TO
cord-006229-7yoilsho	1879	2	examine	examine	VB
cord-006229-7yoilsho	1879	3	the	the	DT
cord-006229-7yoilsho	1879	4	importance	importance	NN
cord-006229-7yoilsho	1879	5	of	of	IN
cord-006229-7yoilsho	1879	6	Jaw1	Jaw1	NNP
cord-006229-7yoilsho	1879	7	in	in	IN
cord-006229-7yoilsho	1879	8	vivo	vivo	NNP
cord-006229-7yoilsho	1879	9	,	,	,
cord-006229-7yoilsho	1879	10	we	-PRON-	PRP
cord-006229-7yoilsho	1879	11	generated	generate	VBD
cord-006229-7yoilsho	1879	12	a	a	DT
cord-006229-7yoilsho	1879	13	conditional	conditional	JJ
cord-006229-7yoilsho	1879	14	knockout	knockout	NN
cord-006229-7yoilsho	1879	15	mouse	mouse	NN
cord-006229-7yoilsho	1879	16	.	.	.
cord-006229-7yoilsho	1880	1	Mating	mate	VBG
cord-006229-7yoilsho	1880	2	with	with	IN
cord-006229-7yoilsho	1880	3	a	a	DT
cord-006229-7yoilsho	1880	4	CMV	CMV	NNP
cord-006229-7yoilsho	1880	5	Cre	Cre	NNP
cord-006229-7yoilsho	1880	6	mouse	mouse	NN
cord-006229-7yoilsho	1880	7	,	,	,
cord-006229-7yoilsho	1880	8	resulted	result	VBD
cord-006229-7yoilsho	1880	9	in	in	IN
cord-006229-7yoilsho	1880	10	an	an	DT
cord-006229-7yoilsho	1880	11	ubiquitous	ubiquitous	JJ
cord-006229-7yoilsho	1880	12	deletion	deletion	NN
cord-006229-7yoilsho	1880	13	of	of	IN
cord-006229-7yoilsho	1880	14	Jaw1	Jaw1	NNP
cord-006229-7yoilsho	1880	15	.	.	.
cord-006229-7yoilsho	1881	1	mRNA	mRNA	NNP
cord-006229-7yoilsho	1881	2	analysis	analysis	NNP
cord-006229-7yoilsho	1881	3	and	and	CC
cord-006229-7yoilsho	1881	4	western	western	JJ
cord-006229-7yoilsho	1881	5	blot	blot	NN
cord-006229-7yoilsho	1881	6	analysis	analysis	NN
cord-006229-7yoilsho	1881	7	approved	approve	VBD
cord-006229-7yoilsho	1881	8	the	the	DT
cord-006229-7yoilsho	1881	9	deletion	deletion	NN
cord-006229-7yoilsho	1881	10	.	.	.
cord-006229-7yoilsho	1882	1	The	the	DT
cord-006229-7yoilsho	1882	2	expression	expression	NN
cord-006229-7yoilsho	1882	3	pattern	pattern	NN
cord-006229-7yoilsho	1882	4	revealed	reveal	VBD
cord-006229-7yoilsho	1882	5	high	high	JJ
cord-006229-7yoilsho	1882	6	expression	expression	NN
cord-006229-7yoilsho	1882	7	in	in	IN
cord-006229-7yoilsho	1882	8	the	the	DT
cord-006229-7yoilsho	1882	9	thymus	thymus	NN
cord-006229-7yoilsho	1882	10	and	and	CC
cord-006229-7yoilsho	1882	11	weaker	weak	JJR
cord-006229-7yoilsho	1882	12	expression	expression	NN
cord-006229-7yoilsho	1882	13	in	in	IN
cord-006229-7yoilsho	1882	14	the	the	DT
cord-006229-7yoilsho	1882	15	lung	lung	NN
cord-006229-7yoilsho	1882	16	,	,	,
cord-006229-7yoilsho	1882	17	spleen	spleen	NN
cord-006229-7yoilsho	1882	18	,	,	,
cord-006229-7yoilsho	1882	19	colon	colon	NN
cord-006229-7yoilsho	1882	20	,	,	,
cord-006229-7yoilsho	1882	21	pancreas	pancreas	NN
cord-006229-7yoilsho	1882	22	and	and	CC
cord-006229-7yoilsho	1882	23	the	the	DT
cord-006229-7yoilsho	1882	24	tongue	tongue	NN
cord-006229-7yoilsho	1882	25	.	.	.
cord-006229-7yoilsho	1883	1	As	as	IN
cord-006229-7yoilsho	1883	2	already	already	RB
cord-006229-7yoilsho	1883	3	published	publish	VBN
cord-006229-7yoilsho	1883	4	by	by	IN
cord-006229-7yoilsho	1883	5	Shindo	Shindo	NNP
cord-006229-7yoilsho	1883	6	et	et	NNP
cord-006229-7yoilsho	1883	7	al	al	NNP
cord-006229-7yoilsho	1883	8	.	.	.
cord-006229-7yoilsho	1884	1	,	,	,
cord-006229-7yoilsho	1884	2	Jaw1	Jaw1	NNP
cord-006229-7yoilsho	1884	3	was	be	VBD
cord-006229-7yoilsho	1884	4	found	find	VBN
cord-006229-7yoilsho	1884	5	in	in	IN
cord-006229-7yoilsho	1884	6	sweet	sweet	JJ
cord-006229-7yoilsho	1884	7	,	,	,
cord-006229-7yoilsho	1884	8	bitter	bitter	JJ
cord-006229-7yoilsho	1884	9	,	,	,
cord-006229-7yoilsho	1884	10	and	and	CC
cord-006229-7yoilsho	1884	11	umami	umami	NN
cord-006229-7yoilsho	1884	12	taste	taste	NN
cord-006229-7yoilsho	1884	13	receptor	receptor	NN
cord-006229-7yoilsho	1884	14	-	-	HYPH
cord-006229-7yoilsho	1884	15	expressing	express	VBG
cord-006229-7yoilsho	1884	16	cells	cell	NNS
cord-006229-7yoilsho	1884	17	of	of	IN
cord-006229-7yoilsho	1884	18	mouse	mouse	NN
cord-006229-7yoilsho	1884	19	circumvallate	circumvallate	NNP
cord-006229-7yoilsho	1884	20	,	,	,
cord-006229-7yoilsho	1884	21	foliate	foliate	NN
cord-006229-7yoilsho	1884	22	,	,	,
cord-006229-7yoilsho	1884	23	and	and	CC
cord-006229-7yoilsho	1884	24	fungiform	fungiform	JJ
cord-006229-7yoilsho	1884	25	papillae	papilla	NNS
cord-006229-7yoilsho	1884	26	.	.	.
cord-006229-7yoilsho	1885	1	We	-PRON-	PRP
cord-006229-7yoilsho	1885	2	confirmed	confirm	VBD
cord-006229-7yoilsho	1885	3	these	these	DT
cord-006229-7yoilsho	1885	4	results	result	NNS
cord-006229-7yoilsho	1885	5	by	by	IN
cord-006229-7yoilsho	1885	6	X	x	NN
cord-006229-7yoilsho	1885	7	-	-	NN
cord-006229-7yoilsho	1885	8	gal	gal	JJ
cord-006229-7yoilsho	1885	9	staining	staining	NN
cord-006229-7yoilsho	1885	10	and	and	CC
cord-006229-7yoilsho	1885	11	mRNA	mrna	NN
cord-006229-7yoilsho	1885	12	analysis	analysis	NN
cord-006229-7yoilsho	1885	13	.	.	.
cord-006229-7yoilsho	1886	1	Therefore	therefore	RB
cord-006229-7yoilsho	1886	2	,	,	,
cord-006229-7yoilsho	1886	3	we	-PRON-	PRP
cord-006229-7yoilsho	1886	4	decided	decide	VBD
cord-006229-7yoilsho	1886	5	to	to	TO
cord-006229-7yoilsho	1886	6	analyse	analyse	VB
cord-006229-7yoilsho	1886	7	if	if	IN
cord-006229-7yoilsho	1886	8	Jaw1	Jaw1	NNP
cord-006229-7yoilsho	1886	9	influences	influence	VBZ
cord-006229-7yoilsho	1886	10	taste	taste	VBP
cord-006229-7yoilsho	1886	11	perception	perception	NN
cord-006229-7yoilsho	1886	12	.	.	.
cord-006229-7yoilsho	1887	1	Two	two	CD
cord-006229-7yoilsho	1887	2	bottle	bottle	NN
cord-006229-7yoilsho	1887	3	preference	preference	NN
cord-006229-7yoilsho	1887	4	tests	test	NNS
cord-006229-7yoilsho	1887	5	did	do	VBD
cord-006229-7yoilsho	1887	6	not	not	RB
cord-006229-7yoilsho	1887	7	result	result	VB
cord-006229-7yoilsho	1887	8	in	in	IN
cord-006229-7yoilsho	1887	9	significant	significant	JJ
cord-006229-7yoilsho	1887	10	differences	difference	NNS
cord-006229-7yoilsho	1887	11	between	between	IN
cord-006229-7yoilsho	1887	12	wildtype	wildtype	NN
cord-006229-7yoilsho	1887	13	and	and	CC
cord-006229-7yoilsho	1887	14	knockout	knockout	NN
cord-006229-7yoilsho	1887	15	mice	mouse	NNS
cord-006229-7yoilsho	1887	16	,	,	,
cord-006229-7yoilsho	1887	17	indicating	indicate	VBG
cord-006229-7yoilsho	1887	18	that	that	IN
cord-006229-7yoilsho	1887	19	taste	taste	VBP
cord-006229-7yoilsho	1887	20	perception	perception	NN
cord-006229-7yoilsho	1887	21	is	be	VBZ
cord-006229-7yoilsho	1887	22	not	not	RB
cord-006229-7yoilsho	1887	23	altered	alter	VBN
cord-006229-7yoilsho	1887	24	by	by	IN
cord-006229-7yoilsho	1887	25	Jaw1	Jaw1	NNP
cord-006229-7yoilsho	1887	26	.	.	.
cord-006229-7yoilsho	1888	1	Hence	hence	RB
cord-006229-7yoilsho	1888	2	,	,	,
cord-006229-7yoilsho	1888	3	the	the	DT
cord-006229-7yoilsho	1888	4	function	function	NN
cord-006229-7yoilsho	1888	5	of	of	IN
cord-006229-7yoilsho	1888	6	Jaw1	Jaw1	NNP
cord-006229-7yoilsho	1888	7	in	in	IN
cord-006229-7yoilsho	1888	8	taste	taste	NN
cord-006229-7yoilsho	1888	9	receptor	receptor	NN
cord-006229-7yoilsho	1888	10	expressing	express	VBG
cord-006229-7yoilsho	1888	11	cells	cell	NNS
cord-006229-7yoilsho	1888	12	has	have	VBZ
cord-006229-7yoilsho	1888	13	to	to	TO
cord-006229-7yoilsho	1888	14	be	be	VB
cord-006229-7yoilsho	1888	15	further	further	RB
cord-006229-7yoilsho	1888	16	examined	examine	VBN
cord-006229-7yoilsho	1888	17	in	in	IN
cord-006229-7yoilsho	1888	18	future	future	JJ
cord-006229-7yoilsho	1888	19	studies	study	NNS
cord-006229-7yoilsho	1888	20	.	.	.
cord-006229-7yoilsho	1889	1	The	the	DT
cord-006229-7yoilsho	1889	2	cyclic	cyclic	JJ
cord-006229-7yoilsho	1889	3	purine	purine	NN
cord-006229-7yoilsho	1889	4	nucleotides	nucleotide	NNS
cord-006229-7yoilsho	1889	5	adenosine	adenosine	NN
cord-006229-7yoilsho	1889	6	3',5'-cyclic	3',5'-cyclic	CD
cord-006229-7yoilsho	1889	7	monophosphate	monophosphate	NN
cord-006229-7yoilsho	1889	8	(	(	-LRB-
cord-006229-7yoilsho	1889	9	cAMP	camp	NN
cord-006229-7yoilsho	1889	10	)	)	-RRB-
cord-006229-7yoilsho	1889	11	and	and	CC
cord-006229-7yoilsho	1889	12	guanosine	guanosine	NN
cord-006229-7yoilsho	1889	13	3',5	3',5	JJ
cord-006229-7yoilsho	1889	14	'	'	''
cord-006229-7yoilsho	1889	15	cyclic	cyclic	JJ
cord-006229-7yoilsho	1889	16	monophosphate	monophosphate	NN
cord-006229-7yoilsho	1889	17	(	(	-LRB-
cord-006229-7yoilsho	1889	18	cGMP	cGMP	NNP
cord-006229-7yoilsho	1889	19	)	)	-RRB-
cord-006229-7yoilsho	1889	20	are	be	VBP
cord-006229-7yoilsho	1889	21	well	well	RB
cord-006229-7yoilsho	1889	22	-	-	HYPH
cord-006229-7yoilsho	1889	23	characterized	characterize	VBN
cord-006229-7yoilsho	1889	24	second	second	JJ
cord-006229-7yoilsho	1889	25	messengers	messenger	NNS
cord-006229-7yoilsho	1889	26	.	.	.
cord-006229-7yoilsho	1890	1	Both	both	DT
cord-006229-7yoilsho	1890	2	are	be	VBP
cord-006229-7yoilsho	1890	3	generated	generate	VBN
cord-006229-7yoilsho	1890	4	by	by	IN
cord-006229-7yoilsho	1890	5	nucleotidyl	nucleotidyl	NNP
cord-006229-7yoilsho	1890	6	cyclases	cyclases	NNP
cord-006229-7yoilsho	1890	7	and	and	CC
cord-006229-7yoilsho	1890	8	degraded	degrade	VBN
cord-006229-7yoilsho	1890	9	by	by	IN
cord-006229-7yoilsho	1890	10	phosphodiesterases	phosphodiesterase	NNS
cord-006229-7yoilsho	1890	11	.	.	.
cord-006229-7yoilsho	1891	1	Several	several	JJ
cord-006229-7yoilsho	1891	2	binding	bind	VBG
cord-006229-7yoilsho	1891	3	partners	partner	NNS
cord-006229-7yoilsho	1891	4	of	of	IN
cord-006229-7yoilsho	1891	5	cAMP	camp	NN
cord-006229-7yoilsho	1891	6	and	and	CC
cord-006229-7yoilsho	1891	7	cGMP	cGMP	NNP
cord-006229-7yoilsho	1891	8	were	be	VBD
cord-006229-7yoilsho	1891	9	already	already	RB
cord-006229-7yoilsho	1891	10	identified	identify	VBN
cord-006229-7yoilsho	1891	11	and	and	CC
cord-006229-7yoilsho	1891	12	functionally	functionally	RB
cord-006229-7yoilsho	1891	13	analyzed	analyze	VBN
cord-006229-7yoilsho	1891	14	,	,	,
cord-006229-7yoilsho	1891	15	e.g.	e.g.	RB
cord-006229-7yoilsho	1891	16	cAMP	camp	NN
cord-006229-7yoilsho	1891	17	-	-	HYPH
cord-006229-7yoilsho	1891	18	dependent	dependent	JJ
cord-006229-7yoilsho	1891	19	protein	protein	NN
cord-006229-7yoilsho	1891	20	kinase	kinase	NN
cord-006229-7yoilsho	1891	21	(	(	-LRB-
cord-006229-7yoilsho	1891	22	PKA	PKA	NNP
cord-006229-7yoilsho	1891	23	)	)	-RRB-
cord-006229-7yoilsho	1891	24	and	and	CC
cord-006229-7yoilsho	1891	25	cGMP	cgmp	JJ
cord-006229-7yoilsho	1891	26	-	-	HYPH
cord-006229-7yoilsho	1891	27	dependent	dependent	JJ
cord-006229-7yoilsho	1891	28	protein	protein	NN
cord-006229-7yoilsho	1891	29	kinase	kinase	NN
cord-006229-7yoilsho	1891	30	(	(	-LRB-
cord-006229-7yoilsho	1891	31	PKG	pkg	NN
cord-006229-7yoilsho	1891	32	)	)	-RRB-
cord-006229-7yoilsho	1891	33	as	as	RB
cord-006229-7yoilsho	1891	34	well	well	RB
cord-006229-7yoilsho	1891	35	as	as	IN
cord-006229-7yoilsho	1891	36	exchange	exchange	NN
cord-006229-7yoilsho	1891	37	protein	protein	NN
cord-006229-7yoilsho	1891	38	activated	activate	VBN
cord-006229-7yoilsho	1891	39	by	by	IN
cord-006229-7yoilsho	1891	40	cAMP	camp	NN
cord-006229-7yoilsho	1891	41	1	1	CD
cord-006229-7yoilsho	1891	42	and	and	CC
cord-006229-7yoilsho	1891	43	2	2	CD
cord-006229-7yoilsho	1891	44	,	,	,
cord-006229-7yoilsho	1891	45	hyperpolarization	hyperpolarization	NN
cord-006229-7yoilsho	1891	46	-	-	HYPH
cord-006229-7yoilsho	1891	47	activated	activate	VBN
cord-006229-7yoilsho	1891	48	cyclic	cyclic	JJ
cord-006229-7yoilsho	1891	49	nucleotide	nucleotide	JJ
cord-006229-7yoilsho	1891	50	gated	gate	VBN
cord-006229-7yoilsho	1891	51	channels	channel	NNS
cord-006229-7yoilsho	1891	52	and	and	CC
cord-006229-7yoilsho	1891	53	phosphodiesterases	phosphodiesterase	NNS
cord-006229-7yoilsho	1891	54	.	.	.
cord-006229-7yoilsho	1892	1	Recent	recent	JJ
cord-006229-7yoilsho	1892	2	data	datum	NNS
cord-006229-7yoilsho	1892	3	indicate	indicate	VBP
cord-006229-7yoilsho	1892	4	that	that	IN
cord-006229-7yoilsho	1892	5	the	the	DT
cord-006229-7yoilsho	1892	6	cyclic	cyclic	JJ
cord-006229-7yoilsho	1892	7	pyrimidine	pyrimidine	NN
cord-006229-7yoilsho	1892	8	nucleotides	nucleotide	NNS
cord-006229-7yoilsho	1892	9	cytosine	cytosine	JJ
cord-006229-7yoilsho	1892	10	3',5'-cyclic	3',5'-cyclic	CD
cord-006229-7yoilsho	1892	11	monophosphate	monophosphate	NN
cord-006229-7yoilsho	1892	12	(	(	-LRB-
cord-006229-7yoilsho	1892	13	cCMP	ccmp	NN
cord-006229-7yoilsho	1892	14	)	)	-RRB-
cord-006229-7yoilsho	1892	15	and	and	CC
cord-006229-7yoilsho	1892	16	uridine	uridine	NNP
cord-006229-7yoilsho	1892	17	3',5'-cyclic	3',5'-cyclic	CD
cord-006229-7yoilsho	1892	18	monophosphate	monophosphate	NN
cord-006229-7yoilsho	1892	19	(	(	-LRB-
cord-006229-7yoilsho	1892	20	cUMP	cump	FW
cord-006229-7yoilsho	1892	21	)	)	-RRB-
cord-006229-7yoilsho	1892	22	also	also	RB
cord-006229-7yoilsho	1892	23	fulfill	fulfill	VB
cord-006229-7yoilsho	1892	24	the	the	DT
cord-006229-7yoilsho	1892	25	criteria	criterion	NNS
cord-006229-7yoilsho	1892	26	of	of	IN
cord-006229-7yoilsho	1892	27	second	second	JJ
cord-006229-7yoilsho	1892	28	messengers	messenger	NNS
cord-006229-7yoilsho	1892	29	[	[	-LRB-
cord-006229-7yoilsho	1892	30	1	1	CD
cord-006229-7yoilsho	1892	31	,	,	,
cord-006229-7yoilsho	1892	32	2	2	CD
cord-006229-7yoilsho	1892	33	]	]	-RRB-
cord-006229-7yoilsho	1892	34	.	.	.
cord-006229-7yoilsho	1893	1	The	the	DT
cord-006229-7yoilsho	1893	2	interaction	interaction	NN
cord-006229-7yoilsho	1893	3	of	of	IN
cord-006229-7yoilsho	1893	4	cCMP	ccmp	NN
cord-006229-7yoilsho	1893	5	with	with	IN
cord-006229-7yoilsho	1893	6	the	the	DT
cord-006229-7yoilsho	1893	7	regulatory	regulatory	JJ
cord-006229-7yoilsho	1893	8	subunits	subunit	NNS
cord-006229-7yoilsho	1893	9	of	of	IN
cord-006229-7yoilsho	1893	10	PKA	PKA	NNP
cord-006229-7yoilsho	1893	11	(	(	-LRB-
cord-006229-7yoilsho	1893	12	PKARIα	PKARIα	NNP
cord-006229-7yoilsho	1893	13	and	and	CC
cord-006229-7yoilsho	1893	14	PKARIIα	PKARIIα	NNP
cord-006229-7yoilsho	1893	15	)	)	-RRB-
cord-006229-7yoilsho	1893	16	has	have	VBZ
cord-006229-7yoilsho	1893	17	already	already	RB
cord-006229-7yoilsho	1893	18	been	be	VBN
cord-006229-7yoilsho	1893	19	shown	show	VBN
cord-006229-7yoilsho	1893	20	by	by	IN
cord-006229-7yoilsho	1893	21	using	use	VBG
cord-006229-7yoilsho	1893	22	cCMPagarose	cCMPagarose	NNP
cord-006229-7yoilsho	1893	23	[	[	-LRB-
cord-006229-7yoilsho	1893	24	3	3	CD
cord-006229-7yoilsho	1893	25	]	]	-RRB-
cord-006229-7yoilsho	1893	26	.	.	.
cord-006229-7yoilsho	1894	1	Additional	additional	JJ
cord-006229-7yoilsho	1894	2	cCMP	ccmp	NN
cord-006229-7yoilsho	1894	3	-	-	:
cord-006229-7yoilsho	1894	4	and	and	CC
cord-006229-7yoilsho	1894	5	cUMP	cUMP	VBN
cord-006229-7yoilsho	1894	6	-	-	HYPH
cord-006229-7yoilsho	1894	7	binding	bind	VBG
cord-006229-7yoilsho	1894	8	proteins	protein	NNS
cord-006229-7yoilsho	1894	9	such	such	JJ
cord-006229-7yoilsho	1894	10	as	as	IN
cord-006229-7yoilsho	1894	11	calnexin	calnexin	NNP
cord-006229-7yoilsho	1894	12	(	(	-LRB-
cord-006229-7yoilsho	1894	13	chaperone	chaperone	NN
cord-006229-7yoilsho	1894	14	)	)	-RRB-
cord-006229-7yoilsho	1894	15	,	,	,
cord-006229-7yoilsho	1894	16	myomegalin	myomegalin	NNP
cord-006229-7yoilsho	1894	17	(	(	-LRB-
cord-006229-7yoilsho	1894	18	phosphodiesterase	phosphodiesterase	NN
cord-006229-7yoilsho	1894	19	-	-	HYPH
cord-006229-7yoilsho	1894	20	interacting	interact	VBG
cord-006229-7yoilsho	1894	21	protein	protein	NN
cord-006229-7yoilsho	1894	22	)	)	-RRB-
cord-006229-7yoilsho	1894	23	and	and	CC
cord-006229-7yoilsho	1894	24	AKAP9	AKAP9	NNS
cord-006229-7yoilsho	1894	25	(	(	-LRB-
cord-006229-7yoilsho	1894	26	A	a	RB
cord-006229-7yoilsho	1894	27	-	-	HYPH
cord-006229-7yoilsho	1894	28	kinase	kinase	NN
cord-006229-7yoilsho	1894	29	anchoring	anchor	VBG
cord-006229-7yoilsho	1894	30	protein	protein	NN
cord-006229-7yoilsho	1894	31	)	)	-RRB-
cord-006229-7yoilsho	1894	32	were	be	VBD
cord-006229-7yoilsho	1894	33	identified	identify	VBN
cord-006229-7yoilsho	1894	34	by	by	IN
cord-006229-7yoilsho	1894	35	mass	mass	JJ
cord-006229-7yoilsho	1894	36	spectrometry	spectrometry	NN
cord-006229-7yoilsho	1894	37	analysis	analysis	NN
cord-006229-7yoilsho	1894	38	.	.	.
cord-006229-7yoilsho	1895	1	To	to	TO
cord-006229-7yoilsho	1895	2	verify	verify	VB
cord-006229-7yoilsho	1895	3	the	the	DT
cord-006229-7yoilsho	1895	4	interaction	interaction	NN
cord-006229-7yoilsho	1895	5	of	of	IN
cord-006229-7yoilsho	1895	6	cCMP	ccmp	NN
cord-006229-7yoilsho	1895	7	and	and	CC
cord-006229-7yoilsho	1895	8	cUMP	cump	XX
cord-006229-7yoilsho	1895	9	with	with	IN
cord-006229-7yoilsho	1895	10	these	these	DT
cord-006229-7yoilsho	1895	11	potential	potential	JJ
cord-006229-7yoilsho	1895	12	target	target	NN
cord-006229-7yoilsho	1895	13	proteins	protein	NNS
cord-006229-7yoilsho	1895	14	,	,	,
cord-006229-7yoilsho	1895	15	cCMP	ccmp	NN
cord-006229-7yoilsho	1895	16	and	and	CC
cord-006229-7yoilsho	1895	17	cUMP	cump	NN
cord-006229-7yoilsho	1895	18	linked	link	VBN
cord-006229-7yoilsho	1895	19	to	to	IN
cord-006229-7yoilsho	1895	20	biotin	biotin	NN
cord-006229-7yoilsho	1895	21	were	be	VBD
cord-006229-7yoilsho	1895	22	used	use	VBN
cord-006229-7yoilsho	1895	23	as	as	IN
cord-006229-7yoilsho	1895	24	another	another	DT
cord-006229-7yoilsho	1895	25	approach	approach	NN
cord-006229-7yoilsho	1895	26	.	.	.
cord-006229-7yoilsho	1896	1	The	the	DT
cord-006229-7yoilsho	1896	2	biotin	biotin	NN
cord-006229-7yoilsho	1896	3	-	-	HYPH
cord-006229-7yoilsho	1896	4	constructs	construct	NNS
cord-006229-7yoilsho	1896	5	exhibit	exhibit	VBP
cord-006229-7yoilsho	1896	6	lower	low	JJR
cord-006229-7yoilsho	1896	7	steric	steric	JJ
cord-006229-7yoilsho	1896	8	interference	interference	NN
cord-006229-7yoilsho	1896	9	than	than	IN
cord-006229-7yoilsho	1896	10	the	the	DT
cord-006229-7yoilsho	1896	11	cCMP	ccmp	NN
cord-006229-7yoilsho	1896	12	-	-	HYPH
cord-006229-7yoilsho	1896	13	and	and	CC
cord-006229-7yoilsho	1896	14	cUMP	cUMP	VBN
cord-006229-7yoilsho	1896	15	-	-	HYPH
cord-006229-7yoilsho	1896	16	agarose	agarose	JJ
cord-006229-7yoilsho	1896	17	matrices	matrix	NNS
cord-006229-7yoilsho	1896	18	,	,	,
cord-006229-7yoilsho	1896	19	which	which	WDT
cord-006229-7yoilsho	1896	20	were	be	VBD
cord-006229-7yoilsho	1896	21	previously	previously	RB
cord-006229-7yoilsho	1896	22	used	use	VBN
cord-006229-7yoilsho	1896	23	to	to	TO
cord-006229-7yoilsho	1896	24	confirm	confirm	VB
cord-006229-7yoilsho	1896	25	the	the	DT
cord-006229-7yoilsho	1896	26	binding	binding	NN
cord-006229-7yoilsho	1896	27	of	of	IN
cord-006229-7yoilsho	1896	28	PKARIα	PKARIα	NNP
cord-006229-7yoilsho	1896	29	to	to	IN
cord-006229-7yoilsho	1896	30	cCMP	ccmp	NN
cord-006229-7yoilsho	1896	31	and	and	CC
cord-006229-7yoilsho	1896	32	cUMP	cUMP	NNP
cord-006229-7yoilsho	1896	33	[	[	-LRB-
cord-006229-7yoilsho	1896	34	4	4	CD
cord-006229-7yoilsho	1896	35	]	]	-RRB-
cord-006229-7yoilsho	1896	36	.	.	.
cord-006229-7yoilsho	1897	1	FLAG	flag	NN
cord-006229-7yoilsho	1897	2	-	-	HYPH
cord-006229-7yoilsho	1897	3	tagged	tag	VBN
cord-006229-7yoilsho	1897	4	calnexin	calnexin	NNP
cord-006229-7yoilsho	1897	5	,	,	,
cord-006229-7yoilsho	1897	6	FLAG	flag	NN
cord-006229-7yoilsho	1897	7	-	-	HYPH
cord-006229-7yoilsho	1897	8	tagged	tag	VBN
cord-006229-7yoilsho	1897	9	myomegalin	myomegalin	NNP
cord-006229-7yoilsho	1897	10	and	and	CC
cord-006229-7yoilsho	1897	11	myc	myc	NNP
cord-006229-7yoilsho	1897	12	-	-	HYPH
cord-006229-7yoilsho	1897	13	tagged	tagged	NNP
cord-006229-7yoilsho	1897	14	Yotiao	Yotiao	NNP
cord-006229-7yoilsho	1897	15	(	(	-LRB-
cord-006229-7yoilsho	1897	16	smallest	small	JJS
cord-006229-7yoilsho	1897	17	splice	splice	NN
cord-006229-7yoilsho	1897	18	-	-	HYPH
cord-006229-7yoilsho	1897	19	variant	variant	NN
cord-006229-7yoilsho	1897	20	of	of	IN
cord-006229-7yoilsho	1897	21	AKAP9	AKAP9	NNS
cord-006229-7yoilsho	1897	22	)	)	-RRB-
cord-006229-7yoilsho	1897	23	were	be	VBD
cord-006229-7yoilsho	1897	24	examined	examine	VBN
cord-006229-7yoilsho	1897	25	as	as	IN
cord-006229-7yoilsho	1897	26	potential	potential	JJ
cord-006229-7yoilsho	1897	27	cCMP	ccmp	NN
cord-006229-7yoilsho	1897	28	and	and	CC
cord-006229-7yoilsho	1897	29	cUMP	cump	NN
cord-006229-7yoilsho	1897	30	target	target	NN
cord-006229-7yoilsho	1897	31	proteins	protein	NNS
cord-006229-7yoilsho	1897	32	.	.	.
cord-006229-7yoilsho	1898	1	HEK293	HEK293	NNP
cord-006229-7yoilsho	1898	2	cells	cell	NNS
cord-006229-7yoilsho	1898	3	were	be	VBD
cord-006229-7yoilsho	1898	4	transiently	transiently	RB
cord-006229-7yoilsho	1898	5	transfected	transfecte	VBN
cord-006229-7yoilsho	1898	6	with	with	IN
cord-006229-7yoilsho	1898	7	the	the	DT
cord-006229-7yoilsho	1898	8	cDNA	cdna	NN
cord-006229-7yoilsho	1898	9	of	of	IN
cord-006229-7yoilsho	1898	10	the	the	DT
cord-006229-7yoilsho	1898	11	respective	respective	JJ
cord-006229-7yoilsho	1898	12	proteins	protein	NNS
cord-006229-7yoilsho	1898	13	.	.	.
cord-006229-7yoilsho	1899	1	The	the	DT
cord-006229-7yoilsho	1899	2	lysates	lysate	NNS
cord-006229-7yoilsho	1899	3	of	of	IN
cord-006229-7yoilsho	1899	4	the	the	DT
cord-006229-7yoilsho	1899	5	protein	protein	NN
cord-006229-7yoilsho	1899	6	-	-	HYPH
cord-006229-7yoilsho	1899	7	overexpressing	overexpresse	VBG
cord-006229-7yoilsho	1899	8	cells	cell	NNS
cord-006229-7yoilsho	1899	9	were	be	VBD
cord-006229-7yoilsho	1899	10	then	then	RB
cord-006229-7yoilsho	1899	11	incubated	incubate	VBN
cord-006229-7yoilsho	1899	12	with	with	IN
cord-006229-7yoilsho	1899	13	cCMP	ccmp	NN
cord-006229-7yoilsho	1899	14	-	-	:
cord-006229-7yoilsho	1899	15	and	and	CC
cord-006229-7yoilsho	1899	16	cUMPbiotin	cUMPbiotin	NNP
cord-006229-7yoilsho	1899	17	matrices	matrix	NNS
cord-006229-7yoilsho	1899	18	and	and	CC
cord-006229-7yoilsho	1899	19	bound	bind	VBN
cord-006229-7yoilsho	1899	20	proteins	protein	NNS
cord-006229-7yoilsho	1899	21	were	be	VBD
cord-006229-7yoilsho	1899	22	purified	purify	VBN
cord-006229-7yoilsho	1899	23	using	use	VBG
cord-006229-7yoilsho	1899	24	Strep	Strep	NNP
cord-006229-7yoilsho	1899	25	-	-	HYPH
cord-006229-7yoilsho	1899	26	Tactin	Tactin	NNP
cord-006229-7yoilsho	1899	27	®	®	POS
cord-006229-7yoilsho	1899	28	beads	bead	NNS
cord-006229-7yoilsho	1899	29	(	(	-LRB-
cord-006229-7yoilsho	1899	30	IBA	IBA	NNP
cord-006229-7yoilsho	1899	31	)	)	-RRB-
cord-006229-7yoilsho	1899	32	.	.	.
cord-006229-7yoilsho	1900	1	Afterwards	afterwards	RB
cord-006229-7yoilsho	1900	2	,	,	,
cord-006229-7yoilsho	1900	3	the	the	DT
cord-006229-7yoilsho	1900	4	interaction	interaction	NN
cord-006229-7yoilsho	1900	5	of	of	IN
cord-006229-7yoilsho	1900	6	cCMP	ccmp	NN
cord-006229-7yoilsho	1900	7	and	and	CC
cord-006229-7yoilsho	1900	8	cUMP	cump	XX
cord-006229-7yoilsho	1900	9	with	with	IN
cord-006229-7yoilsho	1900	10	the	the	DT
cord-006229-7yoilsho	1900	11	potential	potential	JJ
cord-006229-7yoilsho	1900	12	binding	bind	VBG
cord-006229-7yoilsho	1900	13	partners	partner	NNS
cord-006229-7yoilsho	1900	14	was	be	VBD
cord-006229-7yoilsho	1900	15	analyzed	analyze	VBN
cord-006229-7yoilsho	1900	16	by	by	IN
cord-006229-7yoilsho	1900	17	western	western	NN
cord-006229-7yoilsho	1900	18	-	-	HYPH
cord-006229-7yoilsho	1900	19	blotting	blotting	NN
cord-006229-7yoilsho	1900	20	.	.	.
cord-006229-7yoilsho	1901	1	A	a	DT
cord-006229-7yoilsho	1901	2	PKARIα	PKARIα	NNP
cord-006229-7yoilsho	1901	3	antibody	antibody	NN
cord-006229-7yoilsho	1901	4	was	be	VBD
cord-006229-7yoilsho	1901	5	used	use	VBN
cord-006229-7yoilsho	1901	6	as	as	IN
cord-006229-7yoilsho	1901	7	a	a	DT
cord-006229-7yoilsho	1901	8	positive	positive	JJ
cord-006229-7yoilsho	1901	9	control	control	NN
cord-006229-7yoilsho	1901	10	.	.	.
cord-006229-7yoilsho	1902	1	Analogous	analogous	JJ
cord-006229-7yoilsho	1902	2	experiments	experiment	NNS
cord-006229-7yoilsho	1902	3	were	be	VBD
cord-006229-7yoilsho	1902	4	also	also	RB
cord-006229-7yoilsho	1902	5	performed	perform	VBN
cord-006229-7yoilsho	1902	6	using	use	VBG
cord-006229-7yoilsho	1902	7	cCMP	ccmp	NN
cord-006229-7yoilsho	1902	8	-	-	:
cord-006229-7yoilsho	1902	9	and	and	CC
cord-006229-7yoilsho	1902	10	cUMP	cUMP	NNS
cord-006229-7yoilsho	1902	11	-	-	HYPH
cord-006229-7yoilsho	1902	12	agaroses	agarose	NNS
cord-006229-7yoilsho	1902	13	.	.	.
cord-006229-7yoilsho	1903	1	Once	once	IN
cord-006229-7yoilsho	1903	2	the	the	DT
cord-006229-7yoilsho	1903	3	interaction	interaction	NN
cord-006229-7yoilsho	1903	4	between	between	IN
cord-006229-7yoilsho	1903	5	the	the	DT
cord-006229-7yoilsho	1903	6	cyclic	cyclic	JJ
cord-006229-7yoilsho	1903	7	pyrimidine	pyrimidine	NN
cord-006229-7yoilsho	1903	8	nucleotides	nucleotide	NNS
cord-006229-7yoilsho	1903	9	and	and	CC
cord-006229-7yoilsho	1903	10	the	the	DT
cord-006229-7yoilsho	1903	11	potential	potential	JJ
cord-006229-7yoilsho	1903	12	binding	bind	VBG
cord-006229-7yoilsho	1903	13	partners	partner	NNS
cord-006229-7yoilsho	1903	14	has	have	VBZ
cord-006229-7yoilsho	1903	15	been	be	VBN
cord-006229-7yoilsho	1903	16	confirmed	confirm	VBN
cord-006229-7yoilsho	1903	17	,	,	,
cord-006229-7yoilsho	1903	18	deletion	deletion	NN
cord-006229-7yoilsho	1903	19	mutants	mutant	NNS
cord-006229-7yoilsho	1903	20	will	will	MD
cord-006229-7yoilsho	1903	21	be	be	VB
cord-006229-7yoilsho	1903	22	cloned	clone	VBN
cord-006229-7yoilsho	1903	23	to	to	TO
cord-006229-7yoilsho	1903	24	localize	localize	VB
cord-006229-7yoilsho	1903	25	the	the	DT
cord-006229-7yoilsho	1903	26	cCMP	ccmp	NN
cord-006229-7yoilsho	1903	27	-	-	HYPH
cord-006229-7yoilsho	1903	28	and	and	CC
cord-006229-7yoilsho	1903	29	cUMP	cUMP	VBN
cord-006229-7yoilsho	1903	30	-	-	HYPH
cord-006229-7yoilsho	1903	31	binding	binding	JJ
cord-006229-7yoilsho	1903	32	area	area	NN
cord-006229-7yoilsho	1903	33	of	of	IN
cord-006229-7yoilsho	1903	34	the	the	DT
cord-006229-7yoilsho	1903	35	target	target	NN
cord-006229-7yoilsho	1903	36	proteins	protein	NNS
cord-006229-7yoilsho	1903	37	in	in	IN
cord-006229-7yoilsho	1903	38	further	further	JJ
cord-006229-7yoilsho	1903	39	studies	study	NNS
cord-006229-7yoilsho	1903	40	.	.	.
cord-006229-7yoilsho	1904	1	Axonal	axonal	JJ
cord-006229-7yoilsho	1904	2	branching	branching	NN
cord-006229-7yoilsho	1904	3	is	be	VBZ
cord-006229-7yoilsho	1904	4	essential	essential	JJ
cord-006229-7yoilsho	1904	5	for	for	IN
cord-006229-7yoilsho	1904	6	the	the	DT
cord-006229-7yoilsho	1904	7	correct	correct	JJ
cord-006229-7yoilsho	1904	8	formation	formation	NN
cord-006229-7yoilsho	1904	9	of	of	IN
cord-006229-7yoilsho	1904	10	neuronal	neuronal	JJ
cord-006229-7yoilsho	1904	11	circuits	circuit	NNS
cord-006229-7yoilsho	1904	12	and	and	CC
cord-006229-7yoilsho	1904	13	enables	enable	VBZ
cord-006229-7yoilsho	1904	14	the	the	DT
cord-006229-7yoilsho	1904	15	simultaneous	simultaneous	JJ
cord-006229-7yoilsho	1904	16	transmission	transmission	NN
cord-006229-7yoilsho	1904	17	of	of	IN
cord-006229-7yoilsho	1904	18	information	information	NN
cord-006229-7yoilsho	1904	19	throughout	throughout	IN
cord-006229-7yoilsho	1904	20	the	the	DT
cord-006229-7yoilsho	1904	21	body	body	NN
cord-006229-7yoilsho	1904	22	.	.	.
cord-006229-7yoilsho	1905	1	In	in	IN
cord-006229-7yoilsho	1905	2	mice	mouse	NNS
cord-006229-7yoilsho	1905	3	,	,	,
cord-006229-7yoilsho	1905	4	the	the	DT
cord-006229-7yoilsho	1905	5	bifurcation	bifurcation	NN
cord-006229-7yoilsho	1905	6	of	of	IN
cord-006229-7yoilsho	1905	7	axons	axon	NNS
cord-006229-7yoilsho	1905	8	of	of	IN
cord-006229-7yoilsho	1905	9	sensory	sensory	JJ
cord-006229-7yoilsho	1905	10	neurons	neuron	NNS
cord-006229-7yoilsho	1905	11	at	at	IN
cord-006229-7yoilsho	1905	12	the	the	DT
cord-006229-7yoilsho	1905	13	dorsal	dorsal	JJ
cord-006229-7yoilsho	1905	14	root	root	NN
cord-006229-7yoilsho	1905	15	entry	entry	NN
cord-006229-7yoilsho	1905	16	zone	zone	NN
cord-006229-7yoilsho	1905	17	of	of	IN
cord-006229-7yoilsho	1905	18	the	the	DT
cord-006229-7yoilsho	1905	19	developing	develop	VBG
cord-006229-7yoilsho	1905	20	spinal	spinal	JJ
cord-006229-7yoilsho	1905	21	cord	cord	NN
cord-006229-7yoilsho	1905	22	depends	depend	VBZ
cord-006229-7yoilsho	1905	23	on	on	IN
cord-006229-7yoilsho	1905	24	a	a	DT
cord-006229-7yoilsho	1905	25	cGMP	cGMP	NNP
cord-006229-7yoilsho	1905	26	signaling	signal	VBG
cord-006229-7yoilsho	1905	27	cascade	cascade	NN
cord-006229-7yoilsho	1905	28	that	that	WDT
cord-006229-7yoilsho	1905	29	includes	include	VBZ
cord-006229-7yoilsho	1905	30	C	c	NN
cord-006229-7yoilsho	1905	31	-	-	HYPH
cord-006229-7yoilsho	1905	32	type	type	NN
cord-006229-7yoilsho	1905	33	natriuretic	natriuretic	JJ
cord-006229-7yoilsho	1905	34	peptide	peptide	NN
cord-006229-7yoilsho	1905	35	(	(	-LRB-
cord-006229-7yoilsho	1905	36	CNP	CNP	NNP
cord-006229-7yoilsho	1905	37	)	)	-RRB-
cord-006229-7yoilsho	1905	38	,	,	,
cord-006229-7yoilsho	1905	39	natriuretic	natriuretic	JJ
cord-006229-7yoilsho	1905	40	peptide	peptide	NN
cord-006229-7yoilsho	1905	41	receptor	receptor	NN
cord-006229-7yoilsho	1905	42	2	2	CD
cord-006229-7yoilsho	1905	43	(	(	-LRB-
cord-006229-7yoilsho	1905	44	Npr2	Npr2	NNP
cord-006229-7yoilsho	1905	45	,	,	,
cord-006229-7yoilsho	1905	46	also	also	RB
cord-006229-7yoilsho	1905	47	termed	term	VBN
cord-006229-7yoilsho	1905	48	GC	GC	NNP
cord-006229-7yoilsho	1905	49	-	-	HYPH
cord-006229-7yoilsho	1905	50	B	B	NNP
cord-006229-7yoilsho	1905	51	)	)	-RRB-
cord-006229-7yoilsho	1905	52	,	,	,
cord-006229-7yoilsho	1905	53	and	and	CC
cord-006229-7yoilsho	1905	54	cGMPdependent	cGMPdependent	NNP
cord-006229-7yoilsho	1905	55	protein	protein	NN
cord-006229-7yoilsho	1905	56	kinase	kinase	NN
cord-006229-7yoilsho	1905	57	Iα	Iα	NNP
cord-006229-7yoilsho	1905	58	.	.	.
cord-006229-7yoilsho	1906	1	In	in	IN
cord-006229-7yoilsho	1906	2	this	this	DT
cord-006229-7yoilsho	1906	3	study	study	NN
cord-006229-7yoilsho	1906	4	it	-PRON-	PRP
cord-006229-7yoilsho	1906	5	was	be	VBD
cord-006229-7yoilsho	1906	6	investigated	investigate	VBN
cord-006229-7yoilsho	1906	7	,	,	,
cord-006229-7yoilsho	1906	8	if	if	IN
cord-006229-7yoilsho	1906	9	a	a	DT
cord-006229-7yoilsho	1906	10	disturbance	disturbance	NN
cord-006229-7yoilsho	1906	11	of	of	IN
cord-006229-7yoilsho	1906	12	cGMP	cGMP	NNP
cord-006229-7yoilsho	1906	13	signaling	signal	VBG
cord-006229-7yoilsho	1906	14	induced	induce	VBN
cord-006229-7yoilsho	1906	15	by	by	IN
cord-006229-7yoilsho	1906	16	manipulation	manipulation	NN
cord-006229-7yoilsho	1906	17	of	of	IN
cord-006229-7yoilsho	1906	18	cGMP	cGMP	NNP
cord-006229-7yoilsho	1906	19	breakdown	breakdown	NN
cord-006229-7yoilsho	1906	20	or	or	CC
cord-006229-7yoilsho	1906	21	CNP	CNP	NNP
cord-006229-7yoilsho	1906	22	scavenging	scavenging	NN
cord-006229-7yoilsho	1906	23	affects	affect	VBZ
cord-006229-7yoilsho	1906	24	axon	axon	NN
cord-006229-7yoilsho	1906	25	bifurcation	bifurcation	NN
cord-006229-7yoilsho	1906	26	of	of	IN
cord-006229-7yoilsho	1906	27	murine	murine	JJ
cord-006229-7yoilsho	1906	28	embryonic	embryonic	JJ
cord-006229-7yoilsho	1906	29	dorsal	dorsal	JJ
cord-006229-7yoilsho	1906	30	root	root	NN
cord-006229-7yoilsho	1906	31	ganglion	ganglion	NN
cord-006229-7yoilsho	1906	32	(	(	-LRB-
cord-006229-7yoilsho	1906	33	DRG	DRG	NNP
cord-006229-7yoilsho	1906	34	)	)	-RRB-
cord-006229-7yoilsho	1906	35	neurons	neuron	NNS
cord-006229-7yoilsho	1906	36	.	.	.
cord-006229-7yoilsho	1907	1	RT	RT	NNP
cord-006229-7yoilsho	1907	2	-	-	HYPH
cord-006229-7yoilsho	1907	3	PCR	PCR	NNP
cord-006229-7yoilsho	1907	4	screens	screen	NNS
cord-006229-7yoilsho	1907	5	,	,	,
cord-006229-7yoilsho	1907	6	in	in	IN
cord-006229-7yoilsho	1907	7	situ	situ	NN
cord-006229-7yoilsho	1907	8	hybridization	hybridization	NN
cord-006229-7yoilsho	1907	9	,	,	,
cord-006229-7yoilsho	1907	10	and	and	CC
cord-006229-7yoilsho	1907	11	FRET	fret	NN
cord-006229-7yoilsho	1907	12	-	-	HYPH
cord-006229-7yoilsho	1907	13	based	base	VBN
cord-006229-7yoilsho	1907	14	cGMP	cGMP	NNP
cord-006229-7yoilsho	1907	15	imaging	imaging	NN
cord-006229-7yoilsho	1907	16	in	in	IN
cord-006229-7yoilsho	1907	17	living	live	VBG
cord-006229-7yoilsho	1907	18	neurons	neuron	NNS
cord-006229-7yoilsho	1907	19	revealed	reveal	VBD
cord-006229-7yoilsho	1907	20	phosphodiesterase	phosphodiesterase	NN
cord-006229-7yoilsho	1907	21	2A	2a	CD
cord-006229-7yoilsho	1907	22	(	(	-LRB-
cord-006229-7yoilsho	1907	23	PDE2A	PDE2A	NNP
cord-006229-7yoilsho	1907	24	)	)	-RRB-
cord-006229-7yoilsho	1907	25	as	as	IN
cord-006229-7yoilsho	1907	26	the	the	DT
cord-006229-7yoilsho	1907	27	major	major	JJ
cord-006229-7yoilsho	1907	28	enzyme	enzyme	NN
cord-006229-7yoilsho	1907	29	for	for	IN
cord-006229-7yoilsho	1907	30	degradation	degradation	NN
cord-006229-7yoilsho	1907	31	of	of	IN
cord-006229-7yoilsho	1907	32	CNP	CNP	NNP
cord-006229-7yoilsho	1907	33	-	-	HYPH
cord-006229-7yoilsho	1907	34	induced	induce	VBN
cord-006229-7yoilsho	1907	35	cGMP	cGMP	NNP
cord-006229-7yoilsho	1907	36	in	in	IN
cord-006229-7yoilsho	1907	37	embryonic	embryonic	JJ
cord-006229-7yoilsho	1907	38	DRG	DRG	NNP
cord-006229-7yoilsho	1907	39	neurons	neuron	NNS
cord-006229-7yoilsho	1907	40	.	.	.
cord-006229-7yoilsho	1908	1	Interestingly	interestingly	RB
cord-006229-7yoilsho	1908	2	,	,	,
cord-006229-7yoilsho	1908	3	cGMP	cGMP	NNP
cord-006229-7yoilsho	1908	4	measurements	measurement	NNS
cord-006229-7yoilsho	1908	5	and	and	CC
cord-006229-7yoilsho	1908	6	DiI	dii	NN
cord-006229-7yoilsho	1908	7	labeling	labeling	NN
cord-006229-7yoilsho	1908	8	of	of	IN
cord-006229-7yoilsho	1908	9	PDE2A	pde2a	CD
cord-006229-7yoilsho	1908	10	knockout	knockout	NN
cord-006229-7yoilsho	1908	11	embryos	embryo	NNS
cord-006229-7yoilsho	1908	12	indicated	indicate	VBD
cord-006229-7yoilsho	1908	13	that	that	IN
cord-006229-7yoilsho	1908	14	a	a	DT
cord-006229-7yoilsho	1908	15	strongly	strongly	RB
cord-006229-7yoilsho	1908	16	elevated	elevated	JJ
cord-006229-7yoilsho	1908	17	concentration	concentration	NN
cord-006229-7yoilsho	1908	18	of	of	IN
cord-006229-7yoilsho	1908	19	cGMP	cGMP	NNP
cord-006229-7yoilsho	1908	20	does	do	VBZ
cord-006229-7yoilsho	1908	21	not	not	RB
cord-006229-7yoilsho	1908	22	impair	impair	VB
cord-006229-7yoilsho	1908	23	sensory	sensory	JJ
cord-006229-7yoilsho	1908	24	axon	axon	NN
cord-006229-7yoilsho	1908	25	bifurcation	bifurcation	NN
cord-006229-7yoilsho	1908	26	of	of	IN
cord-006229-7yoilsho	1908	27	DRG	DRG	NNP
cord-006229-7yoilsho	1908	28	neurons	neuron	NNS
cord-006229-7yoilsho	1908	29	in	in	IN
cord-006229-7yoilsho	1908	30	vivo	vivo	NN
cord-006229-7yoilsho	1908	31	.	.	.
cord-006229-7yoilsho	1909	1	The	the	DT
cord-006229-7yoilsho	1909	2	natriuretic	natriuretic	JJ
cord-006229-7yoilsho	1909	3	peptide	peptide	NN
cord-006229-7yoilsho	1909	4	receptor	receptor	NN
cord-006229-7yoilsho	1909	5	3	3	CD
cord-006229-7yoilsho	1909	6	(	(	-LRB-
cord-006229-7yoilsho	1909	7	Npr3	Npr3	NNP
cord-006229-7yoilsho	1909	8	)	)	-RRB-
cord-006229-7yoilsho	1909	9	was	be	VBD
cord-006229-7yoilsho	1909	10	found	find	VBN
cord-006229-7yoilsho	1909	11	to	to	TO
cord-006229-7yoilsho	1909	12	be	be	VB
cord-006229-7yoilsho	1909	13	expressed	express	VBN
cord-006229-7yoilsho	1909	14	in	in	IN
cord-006229-7yoilsho	1909	15	the	the	DT
cord-006229-7yoilsho	1909	16	roof	roof	NN
cord-006229-7yoilsho	1909	17	and	and	CC
cord-006229-7yoilsho	1909	18	floor	floor	NN
cord-006229-7yoilsho	1909	19	plate	plate	NN
cord-006229-7yoilsho	1909	20	of	of	IN
cord-006229-7yoilsho	1909	21	the	the	DT
cord-006229-7yoilsho	1909	22	spinal	spinal	JJ
cord-006229-7yoilsho	1909	23	cord	cord	NN
cord-006229-7yoilsho	1909	24	as	as	RB
cord-006229-7yoilsho	1909	25	well	well	RB
cord-006229-7yoilsho	1909	26	as	as	IN
cord-006229-7yoilsho	1909	27	in	in	IN
cord-006229-7yoilsho	1909	28	the	the	DT
cord-006229-7yoilsho	1909	29	dorsal	dorsal	JJ
cord-006229-7yoilsho	1909	30	roots	root	NNS
cord-006229-7yoilsho	1909	31	of	of	IN
cord-006229-7yoilsho	1909	32	E12.5	E12.5	NNP
cord-006229-7yoilsho	1909	33	embryos	embryo	NNS
cord-006229-7yoilsho	1909	34	.	.	.
cord-006229-7yoilsho	1910	1	Because	because	IN
cord-006229-7yoilsho	1910	2	Npr3	Npr3	NNP
cord-006229-7yoilsho	1910	3	binds	bind	VBZ
cord-006229-7yoilsho	1910	4	natriuretic	natriuretic	JJ
cord-006229-7yoilsho	1910	5	peptides	peptide	NNS
cord-006229-7yoilsho	1910	6	,	,	,
cord-006229-7yoilsho	1910	7	but	but	CC
cord-006229-7yoilsho	1910	8	does	do	VBZ
cord-006229-7yoilsho	1910	9	not	not	RB
cord-006229-7yoilsho	1910	10	generate	generate	VB
cord-006229-7yoilsho	1910	11	cGMP	cGMP	NNP
cord-006229-7yoilsho	1910	12	,	,	,
cord-006229-7yoilsho	1910	13	it	-PRON-	PRP
cord-006229-7yoilsho	1910	14	is	be	VBZ
cord-006229-7yoilsho	1910	15	thought	think	VBN
cord-006229-7yoilsho	1910	16	to	to	TO
cord-006229-7yoilsho	1910	17	act	act	VB
cord-006229-7yoilsho	1910	18	as	as	IN
cord-006229-7yoilsho	1910	19	a	a	DT
cord-006229-7yoilsho	1910	20	natriuretic	natriuretic	JJ
cord-006229-7yoilsho	1910	21	peptide	peptide	NN
cord-006229-7yoilsho	1910	22	clearance	clearance	NN
cord-006229-7yoilsho	1910	23	receptor	receptor	NN
cord-006229-7yoilsho	1910	24	.	.	.
cord-006229-7yoilsho	1911	1	By	by	IN
cord-006229-7yoilsho	1911	2	scavenging	scavenge	VBG
cord-006229-7yoilsho	1911	3	CNP	CNP	NNP
cord-006229-7yoilsho	1911	4	,	,	,
cord-006229-7yoilsho	1911	5	Npr3	Npr3	NNP
cord-006229-7yoilsho	1911	6	could	could	MD
cord-006229-7yoilsho	1911	7	lower	lower	VB
cord-006229-7yoilsho	1911	8	the	the	DT
cord-006229-7yoilsho	1911	9	activity	activity	NN
cord-006229-7yoilsho	1911	10	of	of	IN
cord-006229-7yoilsho	1911	11	the	the	DT
cord-006229-7yoilsho	1911	12	CNP	CNP	NNP
cord-006229-7yoilsho	1911	13	-	-	HYPH
cord-006229-7yoilsho	1911	14	Npr2-cGMP	Npr2-cGMP	NNP
cord-006229-7yoilsho	1911	15	signaling	signal	VBG
cord-006229-7yoilsho	1911	16	cascade	cascade	NN
cord-006229-7yoilsho	1911	17	in	in	IN
cord-006229-7yoilsho	1911	18	DRG	DRG	NNP
cord-006229-7yoilsho	1911	19	neurons	neuron	NNS
cord-006229-7yoilsho	1911	20	.	.	.
cord-006229-7yoilsho	1912	1	In	in	IN
cord-006229-7yoilsho	1912	2	the	the	DT
cord-006229-7yoilsho	1912	3	absence	absence	NN
cord-006229-7yoilsho	1912	4	of	of	IN
cord-006229-7yoilsho	1912	5	Npr3	Npr3	NNP
cord-006229-7yoilsho	1912	6	,	,	,
cord-006229-7yoilsho	1912	7	the	the	DT
cord-006229-7yoilsho	1912	8	majority	majority	NN
cord-006229-7yoilsho	1912	9	of	of	IN
cord-006229-7yoilsho	1912	10	sensory	sensory	JJ
cord-006229-7yoilsho	1912	11	axons	axon	NNS
cord-006229-7yoilsho	1912	12	showed	show	VBD
cord-006229-7yoilsho	1912	13	normal	normal	JJ
cord-006229-7yoilsho	1912	14	bifurcation	bifurcation	NN
cord-006229-7yoilsho	1912	15	,	,	,
cord-006229-7yoilsho	1912	16	but	but	CC
cord-006229-7yoilsho	1912	17	»	»	$
cord-006229-7yoilsho	1912	18	13	13	CD
cord-006229-7yoilsho	1912	19	%	%	NN
cord-006229-7yoilsho	1912	20	of	of	IN
cord-006229-7yoilsho	1912	21	the	the	DT
cord-006229-7yoilsho	1912	22	axons	axon	NNS
cord-006229-7yoilsho	1912	23	turned	turn	VBN
cord-006229-7yoilsho	1912	24	only	only	RB
cord-006229-7yoilsho	1912	25	in	in	IN
cord-006229-7yoilsho	1912	26	rostral	rostral	JJ
cord-006229-7yoilsho	1912	27	or	or	CC
cord-006229-7yoilsho	1912	28	caudal	caudal	JJ
cord-006229-7yoilsho	1912	29	direction	direction	NN
cord-006229-7yoilsho	1912	30	.	.	.
cord-006229-7yoilsho	1913	1	This	this	DT
cord-006229-7yoilsho	1913	2	study	study	NN
cord-006229-7yoilsho	1913	3	shows	show	VBZ
cord-006229-7yoilsho	1913	4	(	(	-LRB-
cord-006229-7yoilsho	1913	5	1	1	LS
cord-006229-7yoilsho	1913	6	)	)	-RRB-
cord-006229-7yoilsho	1913	7	that	that	IN
cord-006229-7yoilsho	1913	8	PDE2A	PDE2A	NNP
cord-006229-7yoilsho	1913	9	is	be	VBZ
cord-006229-7yoilsho	1913	10	important	important	JJ
cord-006229-7yoilsho	1913	11	for	for	IN
cord-006229-7yoilsho	1913	12	the	the	DT
cord-006229-7yoilsho	1913	13	degradation	degradation	NN
cord-006229-7yoilsho	1913	14	of	of	IN
cord-006229-7yoilsho	1913	15	cGMP	cGMP	NNP
cord-006229-7yoilsho	1913	16	in	in	IN
cord-006229-7yoilsho	1913	17	embryonic	embryonic	JJ
cord-006229-7yoilsho	1913	18	DRG	DRG	NNP
cord-006229-7yoilsho	1913	19	neurons	neuron	NNS
cord-006229-7yoilsho	1913	20	,	,	,
cord-006229-7yoilsho	1913	21	(	(	-LRB-
cord-006229-7yoilsho	1913	22	2	2	LS
cord-006229-7yoilsho	1913	23	)	)	-RRB-
cord-006229-7yoilsho	1913	24	that	that	IN
cord-006229-7yoilsho	1913	25	the	the	DT
cord-006229-7yoilsho	1913	26	bifurcation	bifurcation	NN
cord-006229-7yoilsho	1913	27	of	of	IN
cord-006229-7yoilsho	1913	28	sensory	sensory	JJ
cord-006229-7yoilsho	1913	29	axons	axon	NNS
cord-006229-7yoilsho	1913	30	in	in	IN
cord-006229-7yoilsho	1913	31	the	the	DT
cord-006229-7yoilsho	1913	32	spinal	spinal	JJ
cord-006229-7yoilsho	1913	33	cord	cord	NN
cord-006229-7yoilsho	1913	34	can	can	MD
cord-006229-7yoilsho	1913	35	tolerate	tolerate	VB
cord-006229-7yoilsho	1913	36	high	high	JJ
cord-006229-7yoilsho	1913	37	levels	level	NNS
cord-006229-7yoilsho	1913	38	of	of	IN
cord-006229-7yoilsho	1913	39	intracellular	intracellular	JJ
cord-006229-7yoilsho	1913	40	cGMP	cgmp	NN
cord-006229-7yoilsho	1913	41	in	in	IN
cord-006229-7yoilsho	1913	42	the	the	DT
cord-006229-7yoilsho	1913	43	absence	absence	NN
cord-006229-7yoilsho	1913	44	of	of	IN
cord-006229-7yoilsho	1913	45	PDE2A	pde2a	CD
cord-006229-7yoilsho	1913	46	,	,	,
cord-006229-7yoilsho	1913	47	and	and	CC
cord-006229-7yoilsho	1913	48	(	(	-LRB-
cord-006229-7yoilsho	1913	49	3	3	LS
cord-006229-7yoilsho	1913	50	)	)	-RRB-
cord-006229-7yoilsho	1914	1	In	in	IN
cord-006229-7yoilsho	1914	2	the	the	DT
cord-006229-7yoilsho	1914	3	central	central	JJ
cord-006229-7yoilsho	1914	4	nervous	nervous	JJ
cord-006229-7yoilsho	1914	5	system	system	NN
cord-006229-7yoilsho	1914	6	,	,	,
cord-006229-7yoilsho	1914	7	NO	no	JJ
cord-006229-7yoilsho	1914	8	-	-	HYPH
cord-006229-7yoilsho	1914	9	dependent	dependent	JJ
cord-006229-7yoilsho	1914	10	cGMP	cGMP	NNP
cord-006229-7yoilsho	1914	11	signalling	signalling	NN
cord-006229-7yoilsho	1914	12	is	be	VBZ
cord-006229-7yoilsho	1914	13	associated	associate	VBN
cord-006229-7yoilsho	1914	14	with	with	IN
cord-006229-7yoilsho	1914	15	many	many	JJ
cord-006229-7yoilsho	1914	16	different	different	JJ
cord-006229-7yoilsho	1914	17	developmental	developmental	JJ
cord-006229-7yoilsho	1914	18	processes	process	NNS
cord-006229-7yoilsho	1914	19	and	and	CC
cord-006229-7yoilsho	1914	20	brain	brain	NN
cord-006229-7yoilsho	1914	21	functions	function	NNS
cord-006229-7yoilsho	1914	22	,	,	,
cord-006229-7yoilsho	1914	23	and	and	CC
cord-006229-7yoilsho	1914	24	plays	play	VBZ
cord-006229-7yoilsho	1914	25	an	an	DT
cord-006229-7yoilsho	1914	26	important	important	JJ
cord-006229-7yoilsho	1914	27	role	role	NN
cord-006229-7yoilsho	1914	28	in	in	IN
cord-006229-7yoilsho	1914	29	memory	memory	NN
cord-006229-7yoilsho	1914	30	consolidation	consolidation	NN
cord-006229-7yoilsho	1914	31	and	and	CC
cord-006229-7yoilsho	1914	32	cognition	cognition	NN
cord-006229-7yoilsho	1914	33	.	.	.
cord-006229-7yoilsho	1915	1	To	to	TO
cord-006229-7yoilsho	1915	2	analyse	analyse	VB
cord-006229-7yoilsho	1915	3	cGMP	cGMP	NNP
cord-006229-7yoilsho	1915	4	signals	signal	NNS
cord-006229-7yoilsho	1915	5	in	in	IN
cord-006229-7yoilsho	1915	6	primary	primary	JJ
cord-006229-7yoilsho	1915	7	cells	cell	NNS
cord-006229-7yoilsho	1915	8	,	,	,
cord-006229-7yoilsho	1915	9	a	a	DT
cord-006229-7yoilsho	1915	10	knock	knock	VB
cord-006229-7yoilsho	1915	11	-	-	HYPH
cord-006229-7yoilsho	1915	12	in	in	RP
cord-006229-7yoilsho	1915	13	mouse	mouse	NN
cord-006229-7yoilsho	1915	14	was	be	VBD
cord-006229-7yoilsho	1915	15	generated	generate	VBN
cord-006229-7yoilsho	1915	16	which	which	WDT
cord-006229-7yoilsho	1915	17	stably	stably	RB
cord-006229-7yoilsho	1915	18	and	and	CC
cord-006229-7yoilsho	1915	19	ubiquitously	ubiquitously	RB
cord-006229-7yoilsho	1915	20	expresses	express	VBZ
cord-006229-7yoilsho	1915	21	a	a	DT
cord-006229-7yoilsho	1915	22	FRET	fret	NN
cord-006229-7yoilsho	1915	23	-	-	HYPH
cord-006229-7yoilsho	1915	24	based	base	VBN
cord-006229-7yoilsho	1915	25	cGMP	cGMP	NNP
cord-006229-7yoilsho	1915	26	indicator	indicator	NN
cord-006229-7yoilsho	1915	27	(	(	-LRB-
cord-006229-7yoilsho	1915	28	cGi500	cGi500	NNP
cord-006229-7yoilsho	1915	29	)	)	-RRB-
cord-006229-7yoilsho	1915	30	.	.	.
cord-006229-7yoilsho	1916	1	Cultured	cultured	JJ
cord-006229-7yoilsho	1916	2	cortical	cortical	JJ
cord-006229-7yoilsho	1916	3	and	and	CC
cord-006229-7yoilsho	1916	4	hippocampal	hippocampal	JJ
cord-006229-7yoilsho	1916	5	neurons	neuron	NNS
cord-006229-7yoilsho	1916	6	were	be	VBD
cord-006229-7yoilsho	1916	7	found	find	VBN
cord-006229-7yoilsho	1916	8	to	to	TO
cord-006229-7yoilsho	1916	9	respond	respond	VB
cord-006229-7yoilsho	1916	10	to	to	IN
cord-006229-7yoilsho	1916	11	exogenously	exogenously	RB
cord-006229-7yoilsho	1916	12	applied	apply	VBN
cord-006229-7yoilsho	1916	13	NO	no	DT
cord-006229-7yoilsho	1916	14	(	(	-LRB-
cord-006229-7yoilsho	1916	15	GSNO	GSNO	NNP
cord-006229-7yoilsho	1916	16	)	)	-RRB-
cord-006229-7yoilsho	1916	17	.	.	.
cord-006229-7yoilsho	1917	1	In	in	IN
cord-006229-7yoilsho	1917	2	these	these	DT
cord-006229-7yoilsho	1917	3	cell	cell	NN
cord-006229-7yoilsho	1917	4	types	type	NNS
cord-006229-7yoilsho	1917	5	,	,	,
cord-006229-7yoilsho	1917	6	endogenous	endogenous	JJ
cord-006229-7yoilsho	1917	7	NO	no	NN
cord-006229-7yoilsho	1917	8	is	be	VBZ
cord-006229-7yoilsho	1917	9	mainly	mainly	RB
cord-006229-7yoilsho	1917	10	generated	generate	VBN
cord-006229-7yoilsho	1917	11	by	by	IN
cord-006229-7yoilsho	1917	12	the	the	DT
cord-006229-7yoilsho	1917	13	neuronal	neuronal	JJ
cord-006229-7yoilsho	1917	14	NO	no	DT
cord-006229-7yoilsho	1917	15	synthase	synthase	NN
cord-006229-7yoilsho	1917	16	(	(	-LRB-
cord-006229-7yoilsho	1917	17	nNOS	nNOS	NNP
cord-006229-7yoilsho	1917	18	)	)	-RRB-
cord-006229-7yoilsho	1917	19	isoform	isoform	NN
cord-006229-7yoilsho	1917	20	which	which	WDT
cord-006229-7yoilsho	1917	21	requires	require	VBZ
cord-006229-7yoilsho	1917	22	a	a	DT
cord-006229-7yoilsho	1917	23	rise	rise	NN
cord-006229-7yoilsho	1917	24	in	in	IN
cord-006229-7yoilsho	1917	25	intracellular	intracellular	JJ
cord-006229-7yoilsho	1917	26	calcium	calcium	NN
cord-006229-7yoilsho	1917	27	for	for	IN
cord-006229-7yoilsho	1917	28	activation	activation	NN
cord-006229-7yoilsho	1917	29	of	of	IN
cord-006229-7yoilsho	1917	30	the	the	DT
cord-006229-7yoilsho	1917	31	NO	NO	NNP
cord-006229-7yoilsho	1917	32	/	/	SYM
cord-006229-7yoilsho	1917	33	cGMP	cgmp	JJ
cord-006229-7yoilsho	1917	34	-	-	HYPH
cord-006229-7yoilsho	1917	35	signalling	signal	VBG
cord-006229-7yoilsho	1917	36	cascade	cascade	NN
cord-006229-7yoilsho	1917	37	.	.	.
cord-006229-7yoilsho	1918	1	Here	here	RB
cord-006229-7yoilsho	1918	2	,	,	,
cord-006229-7yoilsho	1918	3	we	-PRON-	PRP
cord-006229-7yoilsho	1918	4	show	show	VBP
cord-006229-7yoilsho	1918	5	that	that	IN
cord-006229-7yoilsho	1918	6	AMPA	AMPA	NNP
cord-006229-7yoilsho	1918	7	-	-	HYPH
cord-006229-7yoilsho	1918	8	type	type	NN
cord-006229-7yoilsho	1918	9	ionotropic	ionotropic	JJ
cord-006229-7yoilsho	1918	10	glutamate	glutamate	NN
cord-006229-7yoilsho	1918	11	receptors	receptor	NNS
cord-006229-7yoilsho	1918	12	were	be	VBD
cord-006229-7yoilsho	1918	13	capable	capable	JJ
cord-006229-7yoilsho	1918	14	to	to	TO
cord-006229-7yoilsho	1918	15	induce	induce	VB
cord-006229-7yoilsho	1918	16	cGMP	cGMP	NNP
cord-006229-7yoilsho	1918	17	response	response	NN
cord-006229-7yoilsho	1918	18	in	in	IN
cord-006229-7yoilsho	1918	19	cultured	cultured	JJ
cord-006229-7yoilsho	1918	20	cortical	cortical	JJ
cord-006229-7yoilsho	1918	21	and	and	CC
cord-006229-7yoilsho	1918	22	hippocampal	hippocampal	JJ
cord-006229-7yoilsho	1918	23	neurons	neuron	NNS
cord-006229-7yoilsho	1918	24	.	.	.
cord-006229-7yoilsho	1919	1	Surprisingly	surprisingly	RB
cord-006229-7yoilsho	1919	2	,	,	,
cord-006229-7yoilsho	1919	3	AMPARinduced	amparinduced	JJ
cord-006229-7yoilsho	1919	4	cGMP	cGMP	NNP
cord-006229-7yoilsho	1919	5	signals	signal	NNS
cord-006229-7yoilsho	1919	6	were	be	VBD
cord-006229-7yoilsho	1919	7	independent	independent	JJ
cord-006229-7yoilsho	1919	8	of	of	IN
cord-006229-7yoilsho	1919	9	NMDAR	NMDAR	NNP
cord-006229-7yoilsho	1919	10	activation	activation	NN
cord-006229-7yoilsho	1919	11	,	,	,
cord-006229-7yoilsho	1919	12	as	as	IN
cord-006229-7yoilsho	1919	13	inhibition	inhibition	NN
cord-006229-7yoilsho	1919	14	of	of	IN
cord-006229-7yoilsho	1919	15	NMDARs	nmdar	NNS
cord-006229-7yoilsho	1919	16	with	with	IN
cord-006229-7yoilsho	1919	17	the	the	DT
cord-006229-7yoilsho	1919	18	NMDAR	NMDAR	NNP
cord-006229-7yoilsho	1919	19	antagonist	antagonist	NN
cord-006229-7yoilsho	1919	20	D	D	NNP
cord-006229-7yoilsho	1919	21	-	-	HYPH
cord-006229-7yoilsho	1919	22	APV	APV	NNP
cord-006229-7yoilsho	1919	23	(	(	-LRB-
cord-006229-7yoilsho	1919	24	D-2-Amino-5-phosphonopentanoic	d-2-amino-5-phosphonopentanoic	CD
cord-006229-7yoilsho	1919	25	acid	acid	NN
cord-006229-7yoilsho	1919	26	)	)	-RRB-
cord-006229-7yoilsho	1919	27	did	do	VBD
cord-006229-7yoilsho	1919	28	not	not	RB
cord-006229-7yoilsho	1919	29	block	block	VB
cord-006229-7yoilsho	1919	30	AMPAR	AMPAR	NNP
cord-006229-7yoilsho	1919	31	-	-	HYPH
cord-006229-7yoilsho	1919	32	induced	induce	VBN
cord-006229-7yoilsho	1919	33	cGMP	cGMP	NNP
cord-006229-7yoilsho	1919	34	response	response	NN
cord-006229-7yoilsho	1919	35	.	.	.
cord-006229-7yoilsho	1920	1	However	however	RB
cord-006229-7yoilsho	1920	2	,	,	,
cord-006229-7yoilsho	1920	3	cGMP	cGMP	NNP
cord-006229-7yoilsho	1920	4	accumulation	accumulation	NN
cord-006229-7yoilsho	1920	5	depends	depend	VBZ
cord-006229-7yoilsho	1920	6	on	on	IN
cord-006229-7yoilsho	1920	7	NO	no	DT
cord-006229-7yoilsho	1920	8	synthase	synthase	NN
cord-006229-7yoilsho	1920	9	activation	activation	NN
cord-006229-7yoilsho	1920	10	as	as	IN
cord-006229-7yoilsho	1920	11	the	the	DT
cord-006229-7yoilsho	1920	12	NOS	NOS	NNP
cord-006229-7yoilsho	1920	13	inhibitor	inhibitor	NN
cord-006229-7yoilsho	1920	14	L	L	NNP
cord-006229-7yoilsho	1920	15	-	-	HYPH
cord-006229-7yoilsho	1920	16	NNA	NNA	NNP
cord-006229-7yoilsho	1920	17	(	(	-LRB-
cord-006229-7yoilsho	1920	18	NG	NG	NNP
cord-006229-7yoilsho	1920	19	-	-	HYPH
cord-006229-7yoilsho	1920	20	nitro	nitro	NNP
cord-006229-7yoilsho	1920	21	-	-	HYPH
cord-006229-7yoilsho	1920	22	L	l	NN
cord-006229-7yoilsho	1920	23	-	-	HYPH
cord-006229-7yoilsho	1920	24	Arginine	Arginine	NNP
cord-006229-7yoilsho	1920	25	)	)	-RRB-
cord-006229-7yoilsho	1920	26	completely	completely	RB
cord-006229-7yoilsho	1920	27	abolished	abolish	VBD
cord-006229-7yoilsho	1920	28	cGMP	cGMP	NNP
cord-006229-7yoilsho	1920	29	accumulation	accumulation	NN
cord-006229-7yoilsho	1920	30	.	.	.
cord-006229-7yoilsho	1921	1	Whether	whether	IN
cord-006229-7yoilsho	1921	2	AMPAR	AMPAR	NNP
cord-006229-7yoilsho	1921	3	-	-	HYPH
cord-006229-7yoilsho	1921	4	induced	induce	VBN
cord-006229-7yoilsho	1921	5	NOS	NOS	NNP
cord-006229-7yoilsho	1921	6	activation	activation	NN
cord-006229-7yoilsho	1921	7	depends	depend	VBZ
cord-006229-7yoilsho	1921	8	on	on	IN
cord-006229-7yoilsho	1921	9	calcium	calcium	NN
cord-006229-7yoilsho	1921	10	influx	influx	NN
cord-006229-7yoilsho	1921	11	via	via	IN
cord-006229-7yoilsho	1921	12	calcium	calcium	NN
cord-006229-7yoilsho	1921	13	permeable	permeable	JJ
cord-006229-7yoilsho	1921	14	AMPARs	ampar	NNS
cord-006229-7yoilsho	1921	15	,	,	,
cord-006229-7yoilsho	1921	16	VGCCs	vgcc	NNS
cord-006229-7yoilsho	1921	17	(	(	-LRB-
cord-006229-7yoilsho	1921	18	voltage	voltage	VB
cord-006229-7yoilsho	1921	19	gated	gated	JJ
cord-006229-7yoilsho	1921	20	calcium	calcium	NN
cord-006229-7yoilsho	1921	21	channels	channel	NNS
cord-006229-7yoilsho	1921	22	)	)	-RRB-
cord-006229-7yoilsho	1921	23	or	or	CC
cord-006229-7yoilsho	1921	24	calcium	calcium	NN
cord-006229-7yoilsho	1921	25	release	release	NN
cord-006229-7yoilsho	1921	26	from	from	IN
cord-006229-7yoilsho	1921	27	intracellular	intracellular	JJ
cord-006229-7yoilsho	1921	28	stores	store	NNS
cord-006229-7yoilsho	1921	29	will	will	MD
cord-006229-7yoilsho	1921	30	further	further	RB
cord-006229-7yoilsho	1921	31	be	be	VB
cord-006229-7yoilsho	1921	32	investigated	investigate	VBN
cord-006229-7yoilsho	1921	33	in	in	IN
cord-006229-7yoilsho	1921	34	detail	detail	NN
cord-006229-7yoilsho	1921	35	.	.	.
cord-006229-7yoilsho	1922	1	Cyclic	cyclic	JJ
cord-006229-7yoilsho	1922	2	adenosine	adenosine	NN
cord-006229-7yoilsho	1922	3	monophosphate	monophosphate	NN
cord-006229-7yoilsho	1922	4	(	(	-LRB-
cord-006229-7yoilsho	1922	5	cAMP	camp	NN
cord-006229-7yoilsho	1922	6	)	)	-RRB-
cord-006229-7yoilsho	1922	7	is	be	VBZ
cord-006229-7yoilsho	1922	8	an	an	DT
cord-006229-7yoilsho	1922	9	important	important	JJ
cord-006229-7yoilsho	1922	10	and	and	CC
cord-006229-7yoilsho	1922	11	ubiquitous	ubiquitous	JJ
cord-006229-7yoilsho	1922	12	cellular	cellular	JJ
cord-006229-7yoilsho	1922	13	second	second	JJ
cord-006229-7yoilsho	1922	14	messenger	messenger	NN
cord-006229-7yoilsho	1922	15	.	.	.
cord-006229-7yoilsho	1923	1	A	a	DT
cord-006229-7yoilsho	1923	2	dogma	dogma	NN
cord-006229-7yoilsho	1923	3	in	in	IN
cord-006229-7yoilsho	1923	4	signaling	signal	VBG
cord-006229-7yoilsho	1923	5	is	be	VBZ
cord-006229-7yoilsho	1923	6	that	that	DT
cord-006229-7yoilsho	1923	7	cAMP	camp	NN
cord-006229-7yoilsho	1923	8	is	be	VBZ
cord-006229-7yoilsho	1923	9	distributed	distribute	VBN
cord-006229-7yoilsho	1923	10	homogenously	homogenously	RB
cord-006229-7yoilsho	1923	11	in	in	IN
cord-006229-7yoilsho	1923	12	the	the	DT
cord-006229-7yoilsho	1923	13	cell	cell	NN
cord-006229-7yoilsho	1923	14	and	and	CC
cord-006229-7yoilsho	1923	15	that	that	IN
cord-006229-7yoilsho	1923	16	its	-PRON-	PRP$
cord-006229-7yoilsho	1923	17	concentration	concentration	NN
cord-006229-7yoilsho	1923	18	changes	change	VBZ
cord-006229-7yoilsho	1923	19	equally	equally	RB
cord-006229-7yoilsho	1923	20	upon	upon	IN
cord-006229-7yoilsho	1923	21	stimulation	stimulation	NN
cord-006229-7yoilsho	1923	22	.	.	.
cord-006229-7yoilsho	1924	1	In	in	IN
cord-006229-7yoilsho	1924	2	contrast	contrast	NN
cord-006229-7yoilsho	1924	3	,	,	,
cord-006229-7yoilsho	1924	4	a	a	DT
cord-006229-7yoilsho	1924	5	large	large	JJ
cord-006229-7yoilsho	1924	6	body	body	NN
cord-006229-7yoilsho	1924	7	of	of	IN
cord-006229-7yoilsho	1924	8	evidence	evidence	NN
cord-006229-7yoilsho	1924	9	suggests	suggest	VBZ
cord-006229-7yoilsho	1924	10	the	the	DT
cord-006229-7yoilsho	1924	11	existence	existence	NN
cord-006229-7yoilsho	1924	12	of	of	IN
cord-006229-7yoilsho	1924	13	concentration	concentration	NN
cord-006229-7yoilsho	1924	14	gradients	gradient	NNS
cord-006229-7yoilsho	1924	15	(	(	-LRB-
cord-006229-7yoilsho	1924	16	so	so	RB
cord-006229-7yoilsho	1924	17	-	-	HYPH
cord-006229-7yoilsho	1924	18	called	call	VBN
cord-006229-7yoilsho	1924	19	microdomains	microdomain	NNS
cord-006229-7yoilsho	1924	20	)	)	-RRB-
cord-006229-7yoilsho	1924	21	of	of	IN
cord-006229-7yoilsho	1924	22	cAMP	camp	NN
cord-006229-7yoilsho	1924	23	.	.	.
cord-006229-7yoilsho	1925	1	In	in	IN
cord-006229-7yoilsho	1925	2	this	this	DT
cord-006229-7yoilsho	1925	3	regard	regard	NN
cord-006229-7yoilsho	1925	4	,	,	,
cord-006229-7yoilsho	1925	5	phosphodiesterases	phosphodiesterase	NNS
cord-006229-7yoilsho	1925	6	(	(	-LRB-
cord-006229-7yoilsho	1925	7	PDEs	PDEs	NNP
cord-006229-7yoilsho	1925	8	)	)	-RRB-
cord-006229-7yoilsho	1925	9	,	,	,
cord-006229-7yoilsho	1925	10	the	the	DT
cord-006229-7yoilsho	1925	11	only	only	JJ
cord-006229-7yoilsho	1925	12	enzymes	enzyme	NNS
cord-006229-7yoilsho	1925	13	which	which	WDT
cord-006229-7yoilsho	1925	14	can	can	MD
cord-006229-7yoilsho	1925	15	degrade	degrade	VB
cord-006229-7yoilsho	1925	16	cAMP	camp	NN
cord-006229-7yoilsho	1925	17	,	,	,
cord-006229-7yoilsho	1925	18	have	have	VBP
cord-006229-7yoilsho	1925	19	been	be	VBN
cord-006229-7yoilsho	1925	20	suspected	suspect	VBN
cord-006229-7yoilsho	1925	21	to	to	TO
cord-006229-7yoilsho	1925	22	be	be	VB
cord-006229-7yoilsho	1925	23	responsible	responsible	JJ
cord-006229-7yoilsho	1925	24	for	for	IN
cord-006229-7yoilsho	1925	25	maintaining	maintain	VBG
cord-006229-7yoilsho	1925	26	those	those	DT
cord-006229-7yoilsho	1925	27	gradients	gradient	NNS
cord-006229-7yoilsho	1925	28	.	.	.
cord-006229-7yoilsho	1926	1	However	however	RB
cord-006229-7yoilsho	1926	2	,	,	,
cord-006229-7yoilsho	1926	3	how	how	WRB
cord-006229-7yoilsho	1926	4	PDEs	pde	NNS
cord-006229-7yoilsho	1926	5	establish	establish	VBP
cord-006229-7yoilsho	1926	6	cAMP	camp	NN
cord-006229-7yoilsho	1926	7	gradients	gradient	NNS
cord-006229-7yoilsho	1926	8	is	be	VBZ
cord-006229-7yoilsho	1926	9	entirely	entirely	RB
cord-006229-7yoilsho	1926	10	unknown	unknown	JJ
cord-006229-7yoilsho	1926	11	.	.	.
cord-006229-7yoilsho	1927	1	Here	here	RB
cord-006229-7yoilsho	1927	2	,	,	,
cord-006229-7yoilsho	1927	3	we	-PRON-	PRP
cord-006229-7yoilsho	1927	4	measure	measure	VBP
cord-006229-7yoilsho	1927	5	local	local	JJ
cord-006229-7yoilsho	1927	6	cAMP	camp	NN
cord-006229-7yoilsho	1927	7	levels	level	NNS
cord-006229-7yoilsho	1927	8	in	in	IN
cord-006229-7yoilsho	1927	9	HEK	HEK	NNP
cord-006229-7yoilsho	1927	10	cells	cell	NNS
cord-006229-7yoilsho	1927	11	and	and	CC
cord-006229-7yoilsho	1927	12	cytosolic	cytosolic	JJ
cord-006229-7yoilsho	1927	13	fractions	fraction	NNS
cord-006229-7yoilsho	1927	14	thereof	thereof	IN
cord-006229-7yoilsho	1927	15	using	use	VBG
cord-006229-7yoilsho	1927	16	the	the	DT
cord-006229-7yoilsho	1927	17	cAMP	camp	NN
cord-006229-7yoilsho	1927	18	FRETsensor	FRETsensor	NNP
cord-006229-7yoilsho	1927	19	EPAC1-cAMPs	EPAC1-cAMPs	NNP
cord-006229-7yoilsho	1927	20	fused	fuse	VBD
cord-006229-7yoilsho	1927	21	to	to	IN
cord-006229-7yoilsho	1927	22	a	a	DT
cord-006229-7yoilsho	1927	23	phosphodiesterase	phosphodiesterase	NN
cord-006229-7yoilsho	1927	24	(	(	-LRB-
cord-006229-7yoilsho	1927	25	PDE4A1	PDE4A1	NNP
cord-006229-7yoilsho	1927	26	)	)	-RRB-
cord-006229-7yoilsho	1927	27	.	.	.
cord-006229-7yoilsho	1928	1	We	-PRON-	PRP
cord-006229-7yoilsho	1928	2	demonstrate	demonstrate	VBP
cord-006229-7yoilsho	1928	3	the	the	DT
cord-006229-7yoilsho	1928	4	existence	existence	NN
cord-006229-7yoilsho	1928	5	of	of	IN
cord-006229-7yoilsho	1928	6	low	low	JJ
cord-006229-7yoilsho	1928	7	cAMP	camp	NN
cord-006229-7yoilsho	1928	8	concentrations	concentration	NNS
cord-006229-7yoilsho	1928	9	in	in	IN
cord-006229-7yoilsho	1928	10	close	close	JJ
cord-006229-7yoilsho	1928	11	proximity	proximity	NN
cord-006229-7yoilsho	1928	12	to	to	IN
cord-006229-7yoilsho	1928	13	PDEs	pde	NNS
cord-006229-7yoilsho	1928	14	and	and	CC
cord-006229-7yoilsho	1928	15	show	show	VB
cord-006229-7yoilsho	1928	16	that	that	IN
cord-006229-7yoilsho	1928	17	this	this	DT
cord-006229-7yoilsho	1928	18	gradient	gradient	NN
cord-006229-7yoilsho	1928	19	is	be	VBZ
cord-006229-7yoilsho	1928	20	maintained	maintain	VBN
cord-006229-7yoilsho	1928	21	by	by	IN
cord-006229-7yoilsho	1928	22	PDE	pde	NN
cord-006229-7yoilsho	1928	23	hydrolytic	hydrolytic	JJ
cord-006229-7yoilsho	1928	24	activity	activity	NN
cord-006229-7yoilsho	1928	25	.	.	.
cord-006229-7yoilsho	1929	1	Further	further	RB
cord-006229-7yoilsho	1929	2	we	-PRON-	PRP
cord-006229-7yoilsho	1929	3	establish	establish	VBP
cord-006229-7yoilsho	1929	4	that	that	DT
cord-006229-7yoilsho	1929	5	cAMP	camp	NN
cord-006229-7yoilsho	1929	6	gradients	gradient	NNS
cord-006229-7yoilsho	1929	7	can	can	MD
cord-006229-7yoilsho	1929	8	not	not	RB
cord-006229-7yoilsho	1929	9	be	be	VB
cord-006229-7yoilsho	1929	10	maintained	maintain	VBN
cord-006229-7yoilsho	1929	11	solely	solely	RB
cord-006229-7yoilsho	1929	12	on	on	IN
cord-006229-7yoilsho	1929	13	the	the	DT
cord-006229-7yoilsho	1929	14	basis	basis	NN
cord-006229-7yoilsho	1929	15	of	of	IN
cord-006229-7yoilsho	1929	16	PDE	pde	NN
cord-006229-7yoilsho	1929	17	activity	activity	NN
cord-006229-7yoilsho	1929	18	as	as	IN
cord-006229-7yoilsho	1929	19	the	the	DT
cord-006229-7yoilsho	1929	20	cAMP	camp	NN
cord-006229-7yoilsho	1929	21	turnover	turnover	NN
cord-006229-7yoilsho	1929	22	is	be	VBZ
cord-006229-7yoilsho	1929	23	very	very	RB
cord-006229-7yoilsho	1929	24	slow	slow	JJ
cord-006229-7yoilsho	1929	25	.	.	.
cord-006229-7yoilsho	1930	1	We	-PRON-	PRP
cord-006229-7yoilsho	1930	2	provide	provide	VBP
cord-006229-7yoilsho	1930	3	evidence	evidence	NN
cord-006229-7yoilsho	1930	4	that	that	IN
cord-006229-7yoilsho	1930	5	PDEs	pde	NNS
cord-006229-7yoilsho	1930	6	are	be	VBP
cord-006229-7yoilsho	1930	7	structurally	structurally	RB
cord-006229-7yoilsho	1930	8	organized	organize	VBN
cord-006229-7yoilsho	1930	9	in	in	IN
cord-006229-7yoilsho	1930	10	yet	yet	RB
cord-006229-7yoilsho	1930	11	unspecified	unspecified	JJ
cord-006229-7yoilsho	1930	12	'	'	``
cord-006229-7yoilsho	1930	13	microstructures	microstructure	NNS
cord-006229-7yoilsho	1930	14	'	'	''
cord-006229-7yoilsho	1930	15	in	in	IN
cord-006229-7yoilsho	1930	16	which	which	WDT
cord-006229-7yoilsho	1930	17	cAMP	camp	NN
cord-006229-7yoilsho	1930	18	diffusion	diffusion	NN
cord-006229-7yoilsho	1930	19	must	must	MD
cord-006229-7yoilsho	1930	20	be	be	VB
cord-006229-7yoilsho	1930	21	considerably	considerably	RB
cord-006229-7yoilsho	1930	22	slowed	slow	VBN
cord-006229-7yoilsho	1930	23	down	down	RP
cord-006229-7yoilsho	1930	24	.	.	.
cord-006229-7yoilsho	1931	1	Taken	take	VBN
cord-006229-7yoilsho	1931	2	together	together	RB
cord-006229-7yoilsho	1931	3	,	,	,
cord-006229-7yoilsho	1931	4	we	-PRON-	PRP
cord-006229-7yoilsho	1931	5	suggest	suggest	VBP
cord-006229-7yoilsho	1931	6	that	that	IN
cord-006229-7yoilsho	1931	7	cAMP	camp	NN
cord-006229-7yoilsho	1931	8	gradients	gradient	NNS
cord-006229-7yoilsho	1931	9	are	be	VBP
cord-006229-7yoilsho	1931	10	established	establish	VBN
cord-006229-7yoilsho	1931	11	by	by	IN
cord-006229-7yoilsho	1931	12	PDE	pde	NN
cord-006229-7yoilsho	1931	13	hydrolytic	hydrolytic	JJ
cord-006229-7yoilsho	1931	14	activity	activity	NN
cord-006229-7yoilsho	1931	15	in	in	IN
cord-006229-7yoilsho	1931	16	cellular	cellular	JJ
cord-006229-7yoilsho	1931	17	regions	region	NNS
cord-006229-7yoilsho	1931	18	with	with	IN
cord-006229-7yoilsho	1931	19	slow	slow	JJ
cord-006229-7yoilsho	1931	20	diffusion	diffusion	NN
cord-006229-7yoilsho	1931	21	of	of	IN
cord-006229-7yoilsho	1931	22	cAMP	camp	NN
cord-006229-7yoilsho	1931	23	.	.	.
cord-006229-7yoilsho	1932	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	1932	2	study	study	NN
cord-006229-7yoilsho	1932	3	sheds	shed	VBZ
cord-006229-7yoilsho	1932	4	light	light	NN
cord-006229-7yoilsho	1932	5	on	on	IN
cord-006229-7yoilsho	1932	6	the	the	DT
cord-006229-7yoilsho	1932	7	organization	organization	NN
cord-006229-7yoilsho	1932	8	and	and	CC
cord-006229-7yoilsho	1932	9	maintenance	maintenance	NN
cord-006229-7yoilsho	1932	10	of	of	IN
cord-006229-7yoilsho	1932	11	signaling	signal	VBG
cord-006229-7yoilsho	1932	12	compartments	compartment	NNS
cord-006229-7yoilsho	1932	13	in	in	IN
cord-006229-7yoilsho	1932	14	cells	cell	NNS
cord-006229-7yoilsho	1932	15	.	.	.
cord-006229-7yoilsho	1933	1	The	the	DT
cord-006229-7yoilsho	1933	2	influence	influence	NN
cord-006229-7yoilsho	1933	3	of	of	IN
cord-006229-7yoilsho	1933	4	PDE	pde	NN
cord-006229-7yoilsho	1933	5	hydrolytic	hydrolytic	JJ
cord-006229-7yoilsho	1933	6	activity	activity	NN
cord-006229-7yoilsho	1933	7	on	on	IN
cord-006229-7yoilsho	1933	8	cAMP	camp	NN
cord-006229-7yoilsho	1933	9	gradients	gradient	NNS
cord-006229-7yoilsho	1933	10	Universität	Universität	NNP
cord-006229-7yoilsho	1933	11	Würzburg	Würzburg	NNP
cord-006229-7yoilsho	1933	12	,	,	,
cord-006229-7yoilsho	1934	1	Pharmakologie	Pharmakologie	NNP
cord-006229-7yoilsho	1934	2	und	und	IN
cord-006229-7yoilsho	1935	1	Toxikologie	Toxikologie	NNP
cord-006229-7yoilsho	1935	2	,	,	,
cord-006229-7yoilsho	1935	3	Würzburg	Würzburg	NNP
cord-006229-7yoilsho	1935	4	,	,	,
cord-006229-7yoilsho	1935	5	Germany	Germany	NNP
cord-006229-7yoilsho	1935	6	Phosphodiesterases	Phosphodiesterases	NNP
cord-006229-7yoilsho	1935	7	(	(	-LRB-
cord-006229-7yoilsho	1935	8	PDEs	PDEs	NNP
cord-006229-7yoilsho	1935	9	)	)	-RRB-
cord-006229-7yoilsho	1935	10	are	be	VBP
cord-006229-7yoilsho	1935	11	a	a	DT
cord-006229-7yoilsho	1935	12	family	family	NN
cord-006229-7yoilsho	1935	13	of	of	IN
cord-006229-7yoilsho	1935	14	enzymes	enzyme	NNS
cord-006229-7yoilsho	1935	15	that	that	WDT
cord-006229-7yoilsho	1935	16	degrade	degrade	VBP
cord-006229-7yoilsho	1935	17	cyclic	cyclic	JJ
cord-006229-7yoilsho	1935	18	AMP	amp	NN
cord-006229-7yoilsho	1935	19	(	(	-LRB-
cord-006229-7yoilsho	1935	20	cAMP	camp	NN
cord-006229-7yoilsho	1935	21	)	)	-RRB-
cord-006229-7yoilsho	1935	22	and	and	CC
cord-006229-7yoilsho	1935	23	cyclic	cyclic	JJ
cord-006229-7yoilsho	1935	24	GMP	GMP	NNP
cord-006229-7yoilsho	1935	25	(	(	-LRB-
cord-006229-7yoilsho	1935	26	cGMP	cGMP	NNP
cord-006229-7yoilsho	1935	27	)	)	-RRB-
cord-006229-7yoilsho	1935	28	to	to	IN
cord-006229-7yoilsho	1935	29	their	-PRON-	PRP$
cord-006229-7yoilsho	1935	30	respective	respective	JJ
cord-006229-7yoilsho	1935	31	monophosphates	monophosphate	NNS
cord-006229-7yoilsho	1935	32	.	.	.
cord-006229-7yoilsho	1936	1	Although	although	IN
cord-006229-7yoilsho	1936	2	several	several	JJ
cord-006229-7yoilsho	1936	3	PDEs	pde	NNS
cord-006229-7yoilsho	1936	4	have	have	VBP
cord-006229-7yoilsho	1936	5	been	be	VBN
cord-006229-7yoilsho	1936	6	shown	show	VBN
cord-006229-7yoilsho	1936	7	to	to	TO
cord-006229-7yoilsho	1936	8	play	play	VB
cord-006229-7yoilsho	1936	9	an	an	DT
cord-006229-7yoilsho	1936	10	important	important	JJ
cord-006229-7yoilsho	1936	11	role	role	NN
cord-006229-7yoilsho	1936	12	in	in	IN
cord-006229-7yoilsho	1936	13	a	a	DT
cord-006229-7yoilsho	1936	14	wide	wide	JJ
cord-006229-7yoilsho	1936	15	variety	variety	NN
cord-006229-7yoilsho	1936	16	of	of	IN
cord-006229-7yoilsho	1936	17	physiological	physiological	JJ
cord-006229-7yoilsho	1936	18	and	and	CC
cord-006229-7yoilsho	1936	19	pathological	pathological	JJ
cord-006229-7yoilsho	1936	20	processes	process	NNS
cord-006229-7yoilsho	1936	21	,	,	,
cord-006229-7yoilsho	1937	1	their	-PRON-	PRP$
cord-006229-7yoilsho	1937	2	complexity	complexity	NN
cord-006229-7yoilsho	1937	3	and	and	CC
cord-006229-7yoilsho	1937	4	function	function	NN
cord-006229-7yoilsho	1937	5	in	in	IN
cord-006229-7yoilsho	1937	6	cell	cell	NN
cord-006229-7yoilsho	1937	7	signalling	signalling	NN
cord-006229-7yoilsho	1937	8	is	be	VBZ
cord-006229-7yoilsho	1937	9	only	only	RB
cord-006229-7yoilsho	1937	10	beginning	begin	VBG
cord-006229-7yoilsho	1937	11	to	to	TO
cord-006229-7yoilsho	1937	12	be	be	VB
cord-006229-7yoilsho	1937	13	understood	understand	VBN
cord-006229-7yoilsho	1937	14	.	.	.
cord-006229-7yoilsho	1938	1	It	-PRON-	PRP
cord-006229-7yoilsho	1938	2	is	be	VBZ
cord-006229-7yoilsho	1938	3	especially	especially	RB
cord-006229-7yoilsho	1938	4	astonishing	astonishing	JJ
cord-006229-7yoilsho	1938	5	that	that	IN
cord-006229-7yoilsho	1938	6	eukaryotes	eukaryote	NNS
cord-006229-7yoilsho	1938	7	express	express	VBP
cord-006229-7yoilsho	1938	8	more	more	JJR
cord-006229-7yoilsho	1938	9	than	than	IN
cord-006229-7yoilsho	1938	10	100	100	CD
cord-006229-7yoilsho	1938	11	different	different	JJ
cord-006229-7yoilsho	1938	12	PDE	PDE	NNP
cord-006229-7yoilsho	1938	13	isoforms	isoform	NNS
cord-006229-7yoilsho	1938	14	while	while	IN
cord-006229-7yoilsho	1938	15	their	-PRON-	PRP$
cord-006229-7yoilsho	1938	16	single	single	JJ
cord-006229-7yoilsho	1938	17	function	function	NN
cord-006229-7yoilsho	1938	18	is	be	VBZ
cord-006229-7yoilsho	1938	19	to	to	TO
cord-006229-7yoilsho	1938	20	degrade	degrade	VB
cord-006229-7yoilsho	1938	21	cAMP	camp	NN
cord-006229-7yoilsho	1938	22	,	,	,
cord-006229-7yoilsho	1938	23	cGMP	cGMP	NNP
cord-006229-7yoilsho	1938	24	or	or	CC
cord-006229-7yoilsho	1938	25	both	both	DT
cord-006229-7yoilsho	1938	26	.	.	.
cord-006229-7yoilsho	1939	1	In	in	IN
cord-006229-7yoilsho	1939	2	recent	recent	JJ
cord-006229-7yoilsho	1939	3	years	year	NNS
cord-006229-7yoilsho	1939	4	,	,	,
cord-006229-7yoilsho	1939	5	a	a	DT
cord-006229-7yoilsho	1939	6	large	large	JJ
cord-006229-7yoilsho	1939	7	body	body	NN
cord-006229-7yoilsho	1939	8	of	of	IN
cord-006229-7yoilsho	1939	9	evidence	evidence	NN
cord-006229-7yoilsho	1939	10	has	have	VBZ
cord-006229-7yoilsho	1939	11	suggested	suggest	VBN
cord-006229-7yoilsho	1939	12	that	that	IN
cord-006229-7yoilsho	1939	13	PDEs	pde	NNS
cord-006229-7yoilsho	1939	14	(	(	-LRB-
cord-006229-7yoilsho	1939	15	especially	especially	RB
cord-006229-7yoilsho	1939	16	isoforms	isoform	NNS
cord-006229-7yoilsho	1939	17	of	of	IN
cord-006229-7yoilsho	1939	18	the	the	DT
cord-006229-7yoilsho	1939	19	PDE	PDE	NNP
cord-006229-7yoilsho	1939	20	families	family	NNS
cord-006229-7yoilsho	1939	21	3	3	CD
cord-006229-7yoilsho	1939	22	,	,	,
cord-006229-7yoilsho	1939	23	4	4	CD
cord-006229-7yoilsho	1939	24	and	and	CC
cord-006229-7yoilsho	1939	25	5	5	LS
cord-006229-7yoilsho	1939	26	)	)	-RRB-
cord-006229-7yoilsho	1939	27	are	be	VBP
cord-006229-7yoilsho	1939	28	key	key	JJ
cord-006229-7yoilsho	1939	29	players	player	NNS
cord-006229-7yoilsho	1939	30	in	in	IN
cord-006229-7yoilsho	1939	31	establishing	establish	VBG
cord-006229-7yoilsho	1939	32	signalling	signal	VBG
cord-006229-7yoilsho	1939	33	compartments	compartment	NNS
cord-006229-7yoilsho	1939	34	.	.	.
cord-006229-7yoilsho	1940	1	These	these	DT
cord-006229-7yoilsho	1940	2	so	so	RB
cord-006229-7yoilsho	1940	3	-	-	HYPH
cord-006229-7yoilsho	1940	4	called	call	VBN
cord-006229-7yoilsho	1940	5	microdomains	microdomain	NNS
cord-006229-7yoilsho	1940	6	are	be	VBP
cord-006229-7yoilsho	1940	7	yet	yet	RB
cord-006229-7yoilsho	1940	8	unspecified	unspecified	JJ
cord-006229-7yoilsho	1940	9	regions	region	NNS
cord-006229-7yoilsho	1940	10	in	in	IN
cord-006229-7yoilsho	1940	11	cells	cell	NNS
cord-006229-7yoilsho	1940	12	where	where	WRB
cord-006229-7yoilsho	1940	13	the	the	DT
cord-006229-7yoilsho	1940	14	concentrations	concentration	NNS
cord-006229-7yoilsho	1940	15	of	of	IN
cord-006229-7yoilsho	1940	16	cAMP	camp	NN
cord-006229-7yoilsho	1940	17	and	and	CC
cord-006229-7yoilsho	1940	18	cGMP	cGMP	NNP
cord-006229-7yoilsho	1940	19	are	be	VBP
cord-006229-7yoilsho	1940	20	higher	high	JJR
cord-006229-7yoilsho	1940	21	or	or	CC
cord-006229-7yoilsho	1940	22	lower	low	JJR
cord-006229-7yoilsho	1940	23	than	than	IN
cord-006229-7yoilsho	1940	24	in	in	IN
cord-006229-7yoilsho	1940	25	the	the	DT
cord-006229-7yoilsho	1940	26	bulk	bulk	JJ
cord-006229-7yoilsho	1940	27	cytosol	cytosol	NN
cord-006229-7yoilsho	1940	28	.	.	.
cord-006229-7yoilsho	1941	1	In	in	IN
cord-006229-7yoilsho	1941	2	a	a	DT
cord-006229-7yoilsho	1941	3	companion	companion	NN
cord-006229-7yoilsho	1941	4	abstract	abstract	JJ
cord-006229-7yoilsho	1941	5	(	(	-LRB-
cord-006229-7yoilsho	1941	6	Bock	Bock	NNP
cord-006229-7yoilsho	1941	7	&	&	CC
cord-006229-7yoilsho	1941	8	Lohse	Lohse	NNP
cord-006229-7yoilsho	1941	9	)	)	-RRB-
cord-006229-7yoilsho	1941	10	we	-PRON-	PRP
cord-006229-7yoilsho	1941	11	provide	provide	VBP
cord-006229-7yoilsho	1941	12	evidence	evidence	NN
cord-006229-7yoilsho	1941	13	that	that	IN
cord-006229-7yoilsho	1941	14	cAMP	camp	NN
cord-006229-7yoilsho	1941	15	nanodomains	nanodomain	NNS
cord-006229-7yoilsho	1941	16	,	,	,
cord-006229-7yoilsho	1941	17	i.e.	i.e.	FW
cord-006229-7yoilsho	1941	18	regions	region	NNS
cord-006229-7yoilsho	1941	19	of	of	IN
cord-006229-7yoilsho	1941	20	low	low	JJ
cord-006229-7yoilsho	1941	21	cAMP	camp	NN
cord-006229-7yoilsho	1941	22	concentrations	concentration	NNS
cord-006229-7yoilsho	1941	23	,	,	,
cord-006229-7yoilsho	1941	24	exist	exist	VBP
cord-006229-7yoilsho	1941	25	in	in	IN
cord-006229-7yoilsho	1941	26	cells	cell	NNS
cord-006229-7yoilsho	1941	27	in	in	IN
cord-006229-7yoilsho	1941	28	the	the	DT
cord-006229-7yoilsho	1941	29	direct	direct	JJ
cord-006229-7yoilsho	1941	30	vicinity	vicinity	NN
cord-006229-7yoilsho	1941	31	of	of	IN
cord-006229-7yoilsho	1941	32	PDE4	PDE4	NNP
cord-006229-7yoilsho	1941	33	.	.	.
cord-006229-7yoilsho	1942	1	However	however	RB
cord-006229-7yoilsho	1942	2	,	,	,
cord-006229-7yoilsho	1942	3	the	the	DT
cord-006229-7yoilsho	1942	4	mechanisms	mechanism	NNS
cord-006229-7yoilsho	1942	5	by	by	IN
cord-006229-7yoilsho	1942	6	which	which	WDT
cord-006229-7yoilsho	1942	7	PDEs	pde	NNS
cord-006229-7yoilsho	1942	8	establish	establish	VBP
cord-006229-7yoilsho	1942	9	and	and	CC
cord-006229-7yoilsho	1942	10	maintain	maintain	VB
cord-006229-7yoilsho	1942	11	cAMP	camp	NN
cord-006229-7yoilsho	1942	12	gradients	gradient	NNS
cord-006229-7yoilsho	1942	13	are	be	VBP
cord-006229-7yoilsho	1942	14	largely	largely	RB
cord-006229-7yoilsho	1942	15	unknown	unknown	JJ
cord-006229-7yoilsho	1942	16	.	.	.
cord-006229-7yoilsho	1943	1	Here	here	RB
cord-006229-7yoilsho	1943	2	we	-PRON-	PRP
cord-006229-7yoilsho	1943	3	study	study	VBP
cord-006229-7yoilsho	1943	4	if	if	IN
cord-006229-7yoilsho	1943	5	establishing	establish	VBG
cord-006229-7yoilsho	1943	6	cAMP	camp	NN
cord-006229-7yoilsho	1943	7	gradients	gradient	NNS
cord-006229-7yoilsho	1943	8	is	be	VBZ
cord-006229-7yoilsho	1943	9	a	a	DT
cord-006229-7yoilsho	1943	10	general	general	JJ
cord-006229-7yoilsho	1943	11	role	role	NN
cord-006229-7yoilsho	1943	12	of	of	IN
cord-006229-7yoilsho	1943	13	PDEs	pde	NNS
cord-006229-7yoilsho	1943	14	and	and	CC
cord-006229-7yoilsho	1943	15	,	,	,
cord-006229-7yoilsho	1943	16	moreover	moreover	RB
cord-006229-7yoilsho	1943	17	,	,	,
cord-006229-7yoilsho	1943	18	if	if	IN
cord-006229-7yoilsho	1943	19	the	the	DT
cord-006229-7yoilsho	1943	20	size	size	NN
cord-006229-7yoilsho	1943	21	of	of	IN
cord-006229-7yoilsho	1943	22	cAMP	camp	NN
cord-006229-7yoilsho	1943	23	nanodomains	nanodomain	NNS
cord-006229-7yoilsho	1943	24	mainly	mainly	RB
cord-006229-7yoilsho	1943	25	depends	depend	VBZ
cord-006229-7yoilsho	1943	26	on	on	IN
cord-006229-7yoilsho	1943	27	PDE	pde	NN
cord-006229-7yoilsho	1943	28	hydrolytic	hydrolytic	JJ
cord-006229-7yoilsho	1943	29	activity	activity	NN
cord-006229-7yoilsho	1943	30	.	.	.
cord-006229-7yoilsho	1944	1	By	by	IN
cord-006229-7yoilsho	1944	2	fusing	fuse	VBG
cord-006229-7yoilsho	1944	3	an	an	DT
cord-006229-7yoilsho	1944	4	ultra	ultra	JJ
cord-006229-7yoilsho	1944	5	-	-	JJ
cord-006229-7yoilsho	1944	6	fast	fast	JJ
cord-006229-7yoilsho	1944	7	PDE2A3	PDE2A3	NNP
cord-006229-7yoilsho	1944	8	(	(	-LRB-
cord-006229-7yoilsho	1944	9	V	v	NN
cord-006229-7yoilsho	1944	10	max	max	NN
cord-006229-7yoilsho	1944	11	=	=	SYM
cord-006229-7yoilsho	1944	12	120	120	CD
cord-006229-7yoilsho	1944	13	µmol	µmol	NNP
cord-006229-7yoilsho	1944	14	/	/	SYM
cord-006229-7yoilsho	1944	15	min	min	NNP
cord-006229-7yoilsho	1944	16	/	/	SYM
cord-006229-7yoilsho	1944	17	mg	mg	NNP
cord-006229-7yoilsho	1944	18	)	)	-RRB-
cord-006229-7yoilsho	1944	19	to	to	IN
cord-006229-7yoilsho	1944	20	a	a	DT
cord-006229-7yoilsho	1944	21	cAMP	camp	NN
cord-006229-7yoilsho	1944	22	FRET	fret	NN
cord-006229-7yoilsho	1944	23	sensor	sensor	NN
cord-006229-7yoilsho	1944	24	(	(	-LRB-
cord-006229-7yoilsho	1944	25	EPAC1-camps	epac1-camps	NN
cord-006229-7yoilsho	1944	26	)	)	-RRB-
cord-006229-7yoilsho	1944	27	we	-PRON-	PRP
cord-006229-7yoilsho	1944	28	monitor	monitor	VBP
cord-006229-7yoilsho	1944	29	cAMP	camp	NN
cord-006229-7yoilsho	1944	30	concentrations	concentration	NNS
cord-006229-7yoilsho	1944	31	in	in	IN
cord-006229-7yoilsho	1944	32	direct	direct	JJ
cord-006229-7yoilsho	1944	33	vicinity	vicinity	NN
cord-006229-7yoilsho	1944	34	of	of	IN
cord-006229-7yoilsho	1944	35	PDE2A3	PDE2A3	NNP
cord-006229-7yoilsho	1944	36	.	.	.
cord-006229-7yoilsho	1945	1	In	in	IN
cord-006229-7yoilsho	1945	2	comparison	comparison	NN
cord-006229-7yoilsho	1945	3	to	to	IN
cord-006229-7yoilsho	1945	4	PDE4	PDE4	NNP
cord-006229-7yoilsho	1945	5	,	,	,
cord-006229-7yoilsho	1945	6	we	-PRON-	PRP
cord-006229-7yoilsho	1945	7	show	show	VBP
cord-006229-7yoilsho	1945	8	that	that	IN
cord-006229-7yoilsho	1945	9	PDE2A3	PDE2A3	NNP
cord-006229-7yoilsho	1945	10	,	,	,
cord-006229-7yoilsho	1945	11	albeit	albeit	IN
cord-006229-7yoilsho	1945	12	displaying	display	VBG
cord-006229-7yoilsho	1945	13	a	a	DT
cord-006229-7yoilsho	1945	14	high	high	JJ
cord-006229-7yoilsho	1945	15	cAMP	camp	NN
cord-006229-7yoilsho	1945	16	turnover	turnover	NN
cord-006229-7yoilsho	1945	17	,	,	,
cord-006229-7yoilsho	1945	18	only	only	RB
cord-006229-7yoilsho	1945	19	establishes	establish	VBZ
cord-006229-7yoilsho	1945	20	a	a	DT
cord-006229-7yoilsho	1945	21	small	small	JJ
cord-006229-7yoilsho	1945	22	cAMP	camp	NN
cord-006229-7yoilsho	1945	23	gradient	gradient	NN
cord-006229-7yoilsho	1945	24	in	in	IN
cord-006229-7yoilsho	1945	25	both	both	DT
cord-006229-7yoilsho	1945	26	cytosol	cytosol	NN
cord-006229-7yoilsho	1945	27	preparations	preparation	NNS
cord-006229-7yoilsho	1945	28	of	of	IN
cord-006229-7yoilsho	1945	29	transfected	transfecte	VBN
cord-006229-7yoilsho	1945	30	HEK	HEK	NNP
cord-006229-7yoilsho	1945	31	cells	cell	NNS
cord-006229-7yoilsho	1945	32	and	and	CC
cord-006229-7yoilsho	1945	33	in	in	IN
cord-006229-7yoilsho	1945	34	living	living	NN
cord-006229-7yoilsho	1945	35	cells	cell	NNS
cord-006229-7yoilsho	1945	36	.	.	.
cord-006229-7yoilsho	1946	1	Interestingly	interestingly	RB
cord-006229-7yoilsho	1946	2	,	,	,
cord-006229-7yoilsho	1946	3	this	this	DT
cord-006229-7yoilsho	1946	4	gradient	gradient	NN
cord-006229-7yoilsho	1946	5	can	can	MD
cord-006229-7yoilsho	1946	6	be	be	VB
cord-006229-7yoilsho	1946	7	increased	increase	VBN
cord-006229-7yoilsho	1946	8	by	by	IN
cord-006229-7yoilsho	1946	9	deleting	delete	VBG
cord-006229-7yoilsho	1946	10	the	the	DT
cord-006229-7yoilsho	1946	11	Nterminal	Nterminal	NNP
cord-006229-7yoilsho	1946	12	regulatory	regulatory	JJ
cord-006229-7yoilsho	1946	13	domains	domain	NNS
cord-006229-7yoilsho	1946	14	while	while	IN
cord-006229-7yoilsho	1946	15	maintaining	maintain	VBG
cord-006229-7yoilsho	1946	16	fast	fast	JJ
cord-006229-7yoilsho	1946	17	cAMP	camp	NN
cord-006229-7yoilsho	1946	18	turnover	turnover	NN
cord-006229-7yoilsho	1946	19	.	.	.
cord-006229-7yoilsho	1947	1	Biochemical	biochemical	JJ
cord-006229-7yoilsho	1947	2	mapping	mapping	NN
cord-006229-7yoilsho	1947	3	of	of	IN
cord-006229-7yoilsho	1947	4	the	the	DT
cord-006229-7yoilsho	1947	5	cAMP	camp	NN
cord-006229-7yoilsho	1947	6	gradient	gradient	NN
cord-006229-7yoilsho	1947	7	gives	give	VBZ
cord-006229-7yoilsho	1947	8	an	an	DT
cord-006229-7yoilsho	1947	9	estimate	estimate	NN
cord-006229-7yoilsho	1947	10	of	of	IN
cord-006229-7yoilsho	1947	11	the	the	DT
cord-006229-7yoilsho	1947	12	size	size	NN
cord-006229-7yoilsho	1947	13	of	of	IN
cord-006229-7yoilsho	1947	14	nanodomains	nanodomain	NNS
cord-006229-7yoilsho	1947	15	.	.	.
cord-006229-7yoilsho	1948	1	Taken	take	VBN
cord-006229-7yoilsho	1948	2	together	together	RB
cord-006229-7yoilsho	1948	3	,	,	,
cord-006229-7yoilsho	1948	4	our	-PRON-	PRP$
cord-006229-7yoilsho	1948	5	data	datum	NNS
cord-006229-7yoilsho	1948	6	suggest	suggest	VBP
cord-006229-7yoilsho	1948	7	that	that	IN
cord-006229-7yoilsho	1948	8	establishing	establish	VBG
cord-006229-7yoilsho	1948	9	cAMP	camp	NN
cord-006229-7yoilsho	1948	10	gradients	gradient	NNS
cord-006229-7yoilsho	1948	11	does	do	VBZ
cord-006229-7yoilsho	1948	12	not	not	RB
cord-006229-7yoilsho	1948	13	exclusively	exclusively	RB
cord-006229-7yoilsho	1948	14	depend	depend	VB
cord-006229-7yoilsho	1948	15	on	on	IN
cord-006229-7yoilsho	1948	16	PDE	pde	NN
cord-006229-7yoilsho	1948	17	hydrolytic	hydrolytic	JJ
cord-006229-7yoilsho	1948	18	activity	activity	NN
cord-006229-7yoilsho	1948	19	.	.	.
cord-006229-7yoilsho	1949	1	Arglabin	Arglabin	NNP
cord-006229-7yoilsho	1949	2	is	be	VBZ
cord-006229-7yoilsho	1949	3	a	a	DT
cord-006229-7yoilsho	1949	4	plant	plant	NN
cord-006229-7yoilsho	1949	5	-	-	HYPH
cord-006229-7yoilsho	1949	6	derived	derive	VBN
cord-006229-7yoilsho	1949	7	sesquiterpene	sesquiterpene	NN
cord-006229-7yoilsho	1949	8	lactone	lactone	NN
cord-006229-7yoilsho	1949	9	used	use	VBN
cord-006229-7yoilsho	1949	10	for	for	IN
cord-006229-7yoilsho	1949	11	cancer	cancer	NN
cord-006229-7yoilsho	1949	12	therapy	therapy	NN
cord-006229-7yoilsho	1949	13	in	in	IN
cord-006229-7yoilsho	1949	14	Kazakhstan	Kazakhstan	NNP
cord-006229-7yoilsho	1949	15	and	and	CC
cord-006229-7yoilsho	1949	16	Russia	Russia	NNP
cord-006229-7yoilsho	1949	17	.	.	.
cord-006229-7yoilsho	1950	1	Signaling	signal	VBG
cord-006229-7yoilsho	1950	2	pathways	pathway	NNS
cord-006229-7yoilsho	1950	3	targeted	target	VBN
cord-006229-7yoilsho	1950	4	by	by	IN
cord-006229-7yoilsho	1950	5	arglabin	arglabin	NNP
cord-006229-7yoilsho	1950	6	are	be	VBP
cord-006229-7yoilsho	1950	7	poorly	poorly	RB
cord-006229-7yoilsho	1950	8	understood	understand	VBN
cord-006229-7yoilsho	1950	9	.	.	.
cord-006229-7yoilsho	1951	1	We	-PRON-	PRP
cord-006229-7yoilsho	1951	2	have	have	VBP
cord-006229-7yoilsho	1951	3	isolated	isolate	VBN
cord-006229-7yoilsho	1951	4	arglabin	arglabin	NNP
cord-006229-7yoilsho	1951	5	by	by	IN
cord-006229-7yoilsho	1951	6	using	use	VBG
cord-006229-7yoilsho	1951	7	high	high	JJ
cord-006229-7yoilsho	1951	8	performance	performance	NN
cord-006229-7yoilsho	1951	9	liquid	liquid	NN
cord-006229-7yoilsho	1951	10	chromatography	chromatography	NN
cord-006229-7yoilsho	1951	11	from	from	IN
cord-006229-7yoilsho	1951	12	a	a	DT
cord-006229-7yoilsho	1951	13	methanolic	methanolic	JJ
cord-006229-7yoilsho	1951	14	extract	extract	NN
cord-006229-7yoilsho	1951	15	of	of	IN
cord-006229-7yoilsho	1951	16	Artemisia	Artemisia	NNP
cord-006229-7yoilsho	1951	17	glabella	glabella	NNP
cord-006229-7yoilsho	1951	18	,	,	,
cord-006229-7yoilsho	1951	19	a	a	DT
cord-006229-7yoilsho	1951	20	plant	plant	NN
cord-006229-7yoilsho	1951	21	endemic	endemic	JJ
cord-006229-7yoilsho	1951	22	in	in	IN
cord-006229-7yoilsho	1951	23	Kazakhstan	Kazakhstan	NNP
cord-006229-7yoilsho	1951	24	.	.	.
cord-006229-7yoilsho	1952	1	Mass	Mass	NNP
cord-006229-7yoilsho	1952	2	spectrometric	spectrometric	NNP
cord-006229-7yoilsho	1952	3	analyses	analysis	NNS
cord-006229-7yoilsho	1952	4	confirmed	confirm	VBD
cord-006229-7yoilsho	1952	5	the	the	DT
cord-006229-7yoilsho	1952	6	chemical	chemical	NN
cord-006229-7yoilsho	1952	7	structure	structure	NN
cord-006229-7yoilsho	1952	8	and	and	CC
cord-006229-7yoilsho	1952	9	the	the	DT
cord-006229-7yoilsho	1952	10	purity	purity	NN
cord-006229-7yoilsho	1952	11	of	of	IN
cord-006229-7yoilsho	1952	12	the	the	DT
cord-006229-7yoilsho	1952	13	isolated	isolate	VBN
cord-006229-7yoilsho	1952	14	arglabin	arglabin	NNP
cord-006229-7yoilsho	1952	15	.	.	.
cord-006229-7yoilsho	1953	1	In	in	IN
cord-006229-7yoilsho	1953	2	J774	J774	NNS
cord-006229-7yoilsho	1953	3	macrophages	macrophage	NNS
cord-006229-7yoilsho	1953	4	,	,	,
cord-006229-7yoilsho	1953	5	arglabin	arglabin	NNP
cord-006229-7yoilsho	1953	6	strongly	strongly	RB
cord-006229-7yoilsho	1953	7	induced	induce	VBD
cord-006229-7yoilsho	1953	8	accumulation	accumulation	NN
cord-006229-7yoilsho	1953	9	of	of	IN
cord-006229-7yoilsho	1953	10	LC3	LC3	NNP
cord-006229-7yoilsho	1953	11	type	type	NN
cord-006229-7yoilsho	1953	12	II	II	NNP
cord-006229-7yoilsho	1953	13	protein	protein	NN
cord-006229-7yoilsho	1953	14	in	in	IN
cord-006229-7yoilsho	1953	15	the	the	DT
cord-006229-7yoilsho	1953	16	absence	absence	NN
cord-006229-7yoilsho	1953	17	of	of	IN
cord-006229-7yoilsho	1953	18	inflammasome	inflammasome	NN
cord-006229-7yoilsho	1953	19	activators	activator	NNS
cord-006229-7yoilsho	1953	20	,	,	,
cord-006229-7yoilsho	1953	21	and	and	CC
cord-006229-7yoilsho	1953	22	also	also	RB
cord-006229-7yoilsho	1953	23	in	in	IN
cord-006229-7yoilsho	1953	24	cells	cell	NNS
cord-006229-7yoilsho	1953	25	activated	activate	VBN
cord-006229-7yoilsho	1953	26	with	with	IN
cord-006229-7yoilsho	1953	27	LPS	LPS	NNP
cord-006229-7yoilsho	1953	28	and	and	CC
cord-006229-7yoilsho	1953	29	cholesterol	cholesterol	NN
cord-006229-7yoilsho	1953	30	crystals	crystal	NNS
cord-006229-7yoilsho	1953	31	.	.	.
cord-006229-7yoilsho	1954	1	In	in	IN
cord-006229-7yoilsho	1954	2	addition	addition	NN
cord-006229-7yoilsho	1954	3	,	,	,
cord-006229-7yoilsho	1954	4	arglabin	arglabin	NNP
cord-006229-7yoilsho	1954	5	induced	induce	VBN
cord-006229-7yoilsho	1954	6	clustering	clustering	NN
cord-006229-7yoilsho	1954	7	of	of	IN
cord-006229-7yoilsho	1954	8	LC3-II	lc3-ii	NN
cord-006229-7yoilsho	1954	9	at	at	IN
cord-006229-7yoilsho	1954	10	autophagosomal	autophagosomal	NNP
cord-006229-7yoilsho	1954	11	membranes	membrane	NNS
cord-006229-7yoilsho	1954	12	,	,	,
cord-006229-7yoilsho	1954	13	as	as	IN
cord-006229-7yoilsho	1954	14	evidenced	evidence	VBN
cord-006229-7yoilsho	1954	15	from	from	IN
cord-006229-7yoilsho	1954	16	its	-PRON-	PRP$
cord-006229-7yoilsho	1954	17	punctuated	punctuated	JJ
cord-006229-7yoilsho	1954	18	pattern	pattern	NN
cord-006229-7yoilsho	1954	19	in	in	IN
cord-006229-7yoilsho	1954	20	confocal	confocal	JJ
cord-006229-7yoilsho	1954	21	microscopic	microscopic	JJ
cord-006229-7yoilsho	1954	22	images	image	NNS
cord-006229-7yoilsho	1954	23	of	of	IN
cord-006229-7yoilsho	1954	24	arglabin	arglabin	RB
cord-006229-7yoilsho	1954	25	-	-	HYPH
cord-006229-7yoilsho	1954	26	treated	treat	VBN
cord-006229-7yoilsho	1954	27	macrophages	macrophage	NNS
cord-006229-7yoilsho	1954	28	,	,	,
cord-006229-7yoilsho	1954	29	which	which	WDT
cord-006229-7yoilsho	1954	30	is	be	VBZ
cord-006229-7yoilsho	1954	31	a	a	DT
cord-006229-7yoilsho	1954	32	characteristic	characteristic	JJ
cord-006229-7yoilsho	1954	33	sign	sign	NN
cord-006229-7yoilsho	1954	34	for	for	IN
cord-006229-7yoilsho	1954	35	autophagy	autophagy	NN
cord-006229-7yoilsho	1954	36	.	.	.
cord-006229-7yoilsho	1955	1	Since	since	IN
cord-006229-7yoilsho	1955	2	autophagy	autophagy	NN
cord-006229-7yoilsho	1955	3	activation	activation	NN
cord-006229-7yoilsho	1955	4	leads	lead	NNS
cord-006229-7yoilsho	1955	5	to	to	IN
cord-006229-7yoilsho	1955	6	increased	increase	VBN
cord-006229-7yoilsho	1955	7	degradation	degradation	NN
cord-006229-7yoilsho	1955	8	of	of	IN
cord-006229-7yoilsho	1955	9	NLRP3	nlrp3	NN
cord-006229-7yoilsho	1955	10	and	and	CC
cord-006229-7yoilsho	1955	11	pro	pro	JJ
cord-006229-7yoilsho	1955	12	-	-	JJ
cord-006229-7yoilsho	1955	13	interleukin	interleukin	JJ
cord-006229-7yoilsho	1955	14	(	(	-LRB-
cord-006229-7yoilsho	1955	15	IL)-1β	IL)-1β	NNP
cord-006229-7yoilsho	1955	16	,	,	,
cord-006229-7yoilsho	1955	17	we	-PRON-	PRP
cord-006229-7yoilsho	1955	18	further	further	RB
cord-006229-7yoilsho	1955	19	analyzed	analyze	VBD
cord-006229-7yoilsho	1955	20	whether	whether	IN
cord-006229-7yoilsho	1955	21	arglabin	arglabin	NNP
cord-006229-7yoilsho	1955	22	inhibits	inhibit	VBZ
cord-006229-7yoilsho	1955	23	the	the	DT
cord-006229-7yoilsho	1955	24	NLRP3	NLRP3	NNP
cord-006229-7yoilsho	1955	25	inflammasome	inflammasome	NNP
cord-006229-7yoilsho	1955	26	.	.	.
cord-006229-7yoilsho	1956	1	Arglabin	Arglabin	NNP
cord-006229-7yoilsho	1956	2	reduced	reduce	VBN
cord-006229-7yoilsho	1956	3	expression	expression	NN
cord-006229-7yoilsho	1956	4	of	of	IN
cord-006229-7yoilsho	1956	5	NLRP3	nlrp3	NN
cord-006229-7yoilsho	1956	6	and	and	CC
cord-006229-7yoilsho	1956	7	pro	pro	JJ
cord-006229-7yoilsho	1956	8	-	-	JJ
cord-006229-7yoilsho	1956	9	IL-1β	il-1β	JJ
cord-006229-7yoilsho	1956	10	,	,	,
cord-006229-7yoilsho	1956	11	inhibited	inhibited	JJ
cord-006229-7yoilsho	1956	12	activation	activation	NN
cord-006229-7yoilsho	1956	13	of	of	IN
cord-006229-7yoilsho	1956	14	caspase-1	caspase-1	NNP
cord-006229-7yoilsho	1956	15	,	,	,
cord-006229-7yoilsho	1956	16	and	and	CC
cord-006229-7yoilsho	1956	17	release	release	NN
cord-006229-7yoilsho	1956	18	of	of	IN
cord-006229-7yoilsho	1956	19	mature	mature	JJ
cord-006229-7yoilsho	1956	20	IL-1β	IL-1β	NNS
cord-006229-7yoilsho	1956	21	by	by	IN
cord-006229-7yoilsho	1956	22	LPS	LPS	NNP
cord-006229-7yoilsho	1956	23	-	-	HYPH
cord-006229-7yoilsho	1956	24	and	and	CC
cord-006229-7yoilsho	1956	25	cholesterol	cholesterol	NN
cord-006229-7yoilsho	1956	26	-	-	HYPH
cord-006229-7yoilsho	1956	27	crystal	crystal	NN
cord-006229-7yoilsho	1956	28	-	-	HYPH
cord-006229-7yoilsho	1956	29	stimulated	stimulate	VBN
cord-006229-7yoilsho	1956	30	macrophages	macrophage	NNS
cord-006229-7yoilsho	1956	31	consistent	consistent	JJ
cord-006229-7yoilsho	1956	32	with	with	IN
cord-006229-7yoilsho	1956	33	inhibition	inhibition	NN
cord-006229-7yoilsho	1956	34	of	of	IN
cord-006229-7yoilsho	1956	35	the	the	DT
cord-006229-7yoilsho	1956	36	NLRP3	NLRP3	NNP
cord-006229-7yoilsho	1956	37	inflammasome	inflammasome	NNP
cord-006229-7yoilsho	1956	38	.	.	.
cord-006229-7yoilsho	1957	1	Intraperitoneal	intraperitoneal	JJ
cord-006229-7yoilsho	1957	2	injection	injection	NN
cord-006229-7yoilsho	1957	3	of	of	IN
cord-006229-7yoilsho	1957	4	arglabin	arglabin	NNP
cord-006229-7yoilsho	1957	5	into	into	IN
cord-006229-7yoilsho	1957	6	female	female	JJ
cord-006229-7yoilsho	1957	7	ApoE2.Ki	apoe2.ki	NN
cord-006229-7yoilsho	1957	8	mice	mouse	NNS
cord-006229-7yoilsho	1957	9	fed	feed	VBD
cord-006229-7yoilsho	1957	10	a	a	DT
cord-006229-7yoilsho	1957	11	high	high	JJ
cord-006229-7yoilsho	1957	12	fat	fat	NN
cord-006229-7yoilsho	1957	13	diet	diet	NN
cord-006229-7yoilsho	1957	14	resulted	result	VBD
cord-006229-7yoilsho	1957	15	in	in	IN
cord-006229-7yoilsho	1957	16	significantly	significantly	RB
cord-006229-7yoilsho	1957	17	decreased	decrease	VBN
cord-006229-7yoilsho	1957	18	plasma	plasma	NN
cord-006229-7yoilsho	1957	19	levels	level	NNS
cord-006229-7yoilsho	1957	20	of	of	IN
cord-006229-7yoilsho	1957	21	proinflammatory	proinflammatory	JJ
cord-006229-7yoilsho	1957	22	IL-1β	IL-1β	NNS
cord-006229-7yoilsho	1957	23	.	.	.
cord-006229-7yoilsho	1958	1	Moreover	moreover	RB
cord-006229-7yoilsho	1958	2	,	,	,
cord-006229-7yoilsho	1958	3	arglabin	arglabin	NNP
cord-006229-7yoilsho	1958	4	markedly	markedly	RB
cord-006229-7yoilsho	1958	5	reduced	reduce	VBN
cord-006229-7yoilsho	1958	6	mean	mean	JJ
cord-006229-7yoilsho	1958	7	lesion	lesion	NN
cord-006229-7yoilsho	1958	8	areas	area	NNS
cord-006229-7yoilsho	1958	9	in	in	IN
cord-006229-7yoilsho	1958	10	the	the	DT
cord-006229-7yoilsho	1958	11	sinus	sinus	NN
cord-006229-7yoilsho	1958	12	and	and	CC
cord-006229-7yoilsho	1958	13	whole	whole	JJ
cord-006229-7yoilsho	1958	14	aorta	aorta	NN
cord-006229-7yoilsho	1958	15	in	in	IN
cord-006229-7yoilsho	1958	16	mice	mouse	NNS
cord-006229-7yoilsho	1958	17	.	.	.
cord-006229-7yoilsho	1959	1	Thus	thus	RB
cord-006229-7yoilsho	1959	2	,	,	,
cord-006229-7yoilsho	1959	3	arglabin	arglabin	NNP
cord-006229-7yoilsho	1959	4	may	may	MD
cord-006229-7yoilsho	1959	5	represent	represent	VB
cord-006229-7yoilsho	1959	6	a	a	DT
cord-006229-7yoilsho	1959	7	new	new	JJ
cord-006229-7yoilsho	1959	8	promising	promising	JJ
cord-006229-7yoilsho	1959	9	drug	drug	NN
cord-006229-7yoilsho	1959	10	to	to	TO
cord-006229-7yoilsho	1959	11	treat	treat	VB
cord-006229-7yoilsho	1959	12	diseases	disease	NNS
cord-006229-7yoilsho	1959	13	associated	associate	VBN
cord-006229-7yoilsho	1959	14	with	with	IN
cord-006229-7yoilsho	1959	15	inflammasome	inflammasome	NN
cord-006229-7yoilsho	1959	16	activation	activation	NN
cord-006229-7yoilsho	1959	17	,	,	,
cord-006229-7yoilsho	1959	18	e.g.	e.g.	IN
cord-006229-7yoilsho	1959	19	atherosclerosis	atherosclerosis	NN
cord-006229-7yoilsho	1959	20	.	.	.
cord-006229-7yoilsho	1960	1	This	this	DT
cord-006229-7yoilsho	1960	2	work	work	NN
cord-006229-7yoilsho	1960	3	was	be	VBD
cord-006229-7yoilsho	1960	4	supported	support	VBN
cord-006229-7yoilsho	1960	5	in	in	IN
cord-006229-7yoilsho	1960	6	part	part	NN
cord-006229-7yoilsho	1960	7	by	by	IN
cord-006229-7yoilsho	1960	8	a	a	DT
cord-006229-7yoilsho	1960	9	grant	grant	NN
cord-006229-7yoilsho	1960	10	from	from	IN
cord-006229-7yoilsho	1960	11	the	the	DT
cord-006229-7yoilsho	1960	12	Nouvelle	Nouvelle	NNP
cord-006229-7yoilsho	1960	13	Société	Société	NNP
cord-006229-7yoilsho	1960	14	Francophone	Francophone	NNP
cord-006229-7yoilsho	1960	15	d'Athérosclérose	d'Athérosclérose	NNP
cord-006229-7yoilsho	1960	16	(	(	-LRB-
cord-006229-7yoilsho	1960	17	NSFA	NSFA	NNP
cord-006229-7yoilsho	1960	18	)	)	-RRB-
cord-006229-7yoilsho	1960	19	.	.	.
cord-006229-7yoilsho	1961	1	Recently	recently	RB
cord-006229-7yoilsho	1961	2	,	,	,
cord-006229-7yoilsho	1961	3	we	-PRON-	PRP
cord-006229-7yoilsho	1961	4	found	find	VBD
cord-006229-7yoilsho	1961	5	that	that	DT
cord-006229-7yoilsho	1961	6	activation	activation	NN
cord-006229-7yoilsho	1961	7	of	of	IN
cord-006229-7yoilsho	1961	8	the	the	DT
cord-006229-7yoilsho	1961	9	proteinase	proteinase	NN
cord-006229-7yoilsho	1961	10	-	-	HYPH
cord-006229-7yoilsho	1961	11	activated	activate	VBN
cord-006229-7yoilsho	1961	12	receptor	receptor	NN
cord-006229-7yoilsho	1961	13	(	(	-LRB-
cord-006229-7yoilsho	1961	14	PAR	PAR	NNP
cord-006229-7yoilsho	1961	15	)	)	-RRB-
cord-006229-7yoilsho	1961	16	2	2	CD
cord-006229-7yoilsho	1961	17	stimulates	stimulate	VBZ
cord-006229-7yoilsho	1961	18	renin	renin	NN
cord-006229-7yoilsho	1961	19	release	release	NN
cord-006229-7yoilsho	1961	20	in	in	IN
cord-006229-7yoilsho	1961	21	the	the	DT
cord-006229-7yoilsho	1961	22	isolated	isolate	VBN
cord-006229-7yoilsho	1961	23	perfused	perfuse	VBN
cord-006229-7yoilsho	1961	24	kidney	kidney	NN
cord-006229-7yoilsho	1961	25	model	model	NN
cord-006229-7yoilsho	1961	26	.	.	.
cord-006229-7yoilsho	1962	1	Therefore	therefore	RB
cord-006229-7yoilsho	1962	2	,	,	,
cord-006229-7yoilsho	1962	3	we	-PRON-	PRP
cord-006229-7yoilsho	1962	4	determined	determine	VBD
cord-006229-7yoilsho	1962	5	in	in	IN
cord-006229-7yoilsho	1962	6	the	the	DT
cord-006229-7yoilsho	1962	7	current	current	JJ
cord-006229-7yoilsho	1962	8	experiments	experiment	NNS
cord-006229-7yoilsho	1962	9	the	the	DT
cord-006229-7yoilsho	1962	10	response	response	NN
cord-006229-7yoilsho	1962	11	of	of	IN
cord-006229-7yoilsho	1962	12	plasma	plasma	NN
cord-006229-7yoilsho	1962	13	renin	renin	NN
cord-006229-7yoilsho	1962	14	concentration	concentration	NN
cord-006229-7yoilsho	1962	15	(	(	-LRB-
cord-006229-7yoilsho	1962	16	PRC	PRC	NNP
cord-006229-7yoilsho	1962	17	)	)	-RRB-
cord-006229-7yoilsho	1962	18	to	to	TO
cord-006229-7yoilsho	1962	19	acute	acute	JJ
cord-006229-7yoilsho	1962	20	intraperitoneal	intraperitoneal	JJ
cord-006229-7yoilsho	1962	21	administration	administration	NN
cord-006229-7yoilsho	1962	22	of	of	IN
cord-006229-7yoilsho	1962	23	the	the	DT
cord-006229-7yoilsho	1962	24	PAR2	PAR2	NNP
cord-006229-7yoilsho	1962	25	activating	activate	VBG
cord-006229-7yoilsho	1962	26	peptide	peptide	JJ
cord-006229-7yoilsho	1962	27	SLIGRL	SLIGRL	NNS
cord-006229-7yoilsho	1962	28	(	(	-LRB-
cord-006229-7yoilsho	1962	29	100µg	100µg	NNP
cord-006229-7yoilsho	1962	30	/	/	SYM
cord-006229-7yoilsho	1962	31	kg	kg	NNP
cord-006229-7yoilsho	1962	32	)	)	-RRB-
cord-006229-7yoilsho	1962	33	,	,	,
cord-006229-7yoilsho	1962	34	hydralazine	hydralazine	NNP
cord-006229-7yoilsho	1962	35	(	(	-LRB-
cord-006229-7yoilsho	1962	36	2	2	CD
cord-006229-7yoilsho	1962	37	mg	mg	NNP
cord-006229-7yoilsho	1962	38	/	/	SYM
cord-006229-7yoilsho	1962	39	kg	kg	NNP
cord-006229-7yoilsho	1962	40	)	)	-RRB-
cord-006229-7yoilsho	1962	41	,	,	,
cord-006229-7yoilsho	1962	42	isoproterenol	isoproterenol	NNP
cord-006229-7yoilsho	1962	43	(	(	-LRB-
cord-006229-7yoilsho	1962	44	10	10	CD
cord-006229-7yoilsho	1962	45	mg	mg	NNP
cord-006229-7yoilsho	1962	46	/	/	SYM
cord-006229-7yoilsho	1962	47	kg	kg	NNP
cord-006229-7yoilsho	1962	48	)	)	-RRB-
cord-006229-7yoilsho	1962	49	,	,	,
cord-006229-7yoilsho	1962	50	losartan	losartan	NNP
cord-006229-7yoilsho	1962	51	(	(	-LRB-
cord-006229-7yoilsho	1962	52	3	3	CD
cord-006229-7yoilsho	1962	53	mg	mg	NNP
cord-006229-7yoilsho	1962	54	/	/	SYM
cord-006229-7yoilsho	1962	55	kg	kg	NNP
cord-006229-7yoilsho	1962	56	)	)	-RRB-
cord-006229-7yoilsho	1962	57	and	and	CC
cord-006229-7yoilsho	1962	58	furosemide	furosemide	NN
cord-006229-7yoilsho	1962	59	(	(	-LRB-
cord-006229-7yoilsho	1962	60	40	40	CD
cord-006229-7yoilsho	1962	61	mg	mg	NNP
cord-006229-7yoilsho	1962	62	/	/	SYM
cord-006229-7yoilsho	1962	63	kg	kg	NNP
cord-006229-7yoilsho	1962	64	)	)	-RRB-
cord-006229-7yoilsho	1962	65	in	in	IN
cord-006229-7yoilsho	1962	66	conscious	conscious	JJ
cord-006229-7yoilsho	1962	67	wild	wild	JJ
cord-006229-7yoilsho	1962	68	-	-	HYPH
cord-006229-7yoilsho	1962	69	type	type	NN
cord-006229-7yoilsho	1962	70	(	(	-LRB-
cord-006229-7yoilsho	1962	71	WT	WT	NNP
cord-006229-7yoilsho	1962	72	)	)	-RRB-
cord-006229-7yoilsho	1962	73	and	and	CC
cord-006229-7yoilsho	1962	74	PAR2-deficient	PAR2-deficient	NNP
cord-006229-7yoilsho	1962	75	mice	mouse	NNS
cord-006229-7yoilsho	1962	76	.	.	.
cord-006229-7yoilsho	1963	1	PRC	PRC	NNP
cord-006229-7yoilsho	1963	2	was	be	VBD
cord-006229-7yoilsho	1963	3	measured	measure	VBN
cord-006229-7yoilsho	1963	4	in	in	IN
cord-006229-7yoilsho	1963	5	plasma	plasma	NN
cord-006229-7yoilsho	1963	6	obtained	obtain	VBN
cord-006229-7yoilsho	1963	7	by	by	IN
cord-006229-7yoilsho	1963	8	tail	tail	NN
cord-006229-7yoilsho	1963	9	vein	vein	NN
cord-006229-7yoilsho	1963	10	puncture	puncture	NN
cord-006229-7yoilsho	1963	11	.	.	.
cord-006229-7yoilsho	1964	1	Renal	renal	JJ
cord-006229-7yoilsho	1964	2	renin	renin	NN
cord-006229-7yoilsho	1964	3	expression	expression	NN
cord-006229-7yoilsho	1964	4	was	be	VBD
cord-006229-7yoilsho	1964	5	determined	determine	VBN
cord-006229-7yoilsho	1964	6	by	by	IN
cord-006229-7yoilsho	1964	7	quantitative	quantitative	JJ
cord-006229-7yoilsho	1964	8	RT	RT	NNP
cord-006229-7yoilsho	1964	9	-	-	HYPH
cord-006229-7yoilsho	1964	10	PCR	PCR	NNP
cord-006229-7yoilsho	1964	11	.	.	.
cord-006229-7yoilsho	1965	1	Renal	renal	JJ
cord-006229-7yoilsho	1965	2	protein	protein	NN
cord-006229-7yoilsho	1965	3	expression	expression	NN
cord-006229-7yoilsho	1965	4	was	be	VBD
cord-006229-7yoilsho	1965	5	measured	measure	VBN
cord-006229-7yoilsho	1965	6	by	by	IN
cord-006229-7yoilsho	1965	7	immunohistochemistry	immunohistochemistry	NN
cord-006229-7yoilsho	1965	8	.	.	.
cord-006229-7yoilsho	1966	1	On	on	IN
cord-006229-7yoilsho	1966	2	a	a	DT
cord-006229-7yoilsho	1966	3	control	control	NN
cord-006229-7yoilsho	1966	4	diet	diet	NN
cord-006229-7yoilsho	1966	5	(	(	-LRB-
cord-006229-7yoilsho	1966	6	0.6	0.6	CD
cord-006229-7yoilsho	1966	7	%	%	NN
cord-006229-7yoilsho	1966	8	NaCl	nacl	NN
cord-006229-7yoilsho	1966	9	)	)	-RRB-
cord-006229-7yoilsho	1966	10	,	,	,
cord-006229-7yoilsho	1966	11	plasma	plasma	NN
cord-006229-7yoilsho	1966	12	renin	renin	NN
cord-006229-7yoilsho	1966	13	concentration	concentration	NN
cord-006229-7yoilsho	1966	14	(	(	-LRB-
cord-006229-7yoilsho	1966	15	in	in	IN
cord-006229-7yoilsho	1966	16	ng	ng	NNP
cord-006229-7yoilsho	1966	17	angiotensin	angiotensin	NN
cord-006229-7yoilsho	1966	18	I	-PRON-	PRP
cord-006229-7yoilsho	1966	19	per	per	IN
cord-006229-7yoilsho	1966	20	mL	ml	NN
cord-006229-7yoilsho	1966	21	per	per	IN
cord-006229-7yoilsho	1966	22	hour	hour	NN
cord-006229-7yoilsho	1966	23	)	)	-RRB-
cord-006229-7yoilsho	1966	24	was	be	VBD
cord-006229-7yoilsho	1966	25	significantly	significantly	RB
cord-006229-7yoilsho	1966	26	lower	low	JJR
cord-006229-7yoilsho	1966	27	in	in	IN
cord-006229-7yoilsho	1966	28	PAR2-deficient	par2-deficient	NN
cord-006229-7yoilsho	1966	29	mice	mouse	NNS
cord-006229-7yoilsho	1966	30	than	than	IN
cord-006229-7yoilsho	1966	31	in	in	IN
cord-006229-7yoilsho	1966	32	wild	wild	JJ
cord-006229-7yoilsho	1966	33	-	-	HYPH
cord-006229-7yoilsho	1966	34	type	type	NN
cord-006229-7yoilsho	1966	35	mice	mouse	NNS
cord-006229-7yoilsho	1966	36	(	(	-LRB-
cord-006229-7yoilsho	1966	37	190	190	CD
cord-006229-7yoilsho	1966	38	±	±	CD
cord-006229-7yoilsho	1966	39	35	35	CD
cord-006229-7yoilsho	1966	40	versus	versus	IN
cord-006229-7yoilsho	1966	41	380	380	CD
cord-006229-7yoilsho	1966	42	±	±	CD
cord-006229-7yoilsho	1966	43	91	91	CD
cord-006229-7yoilsho	1966	44	)	)	-RRB-
cord-006229-7yoilsho	1966	45	.	.	.
cord-006229-7yoilsho	1967	1	Renin	renin	NN
cord-006229-7yoilsho	1967	2	mRNA	mrna	NN
cord-006229-7yoilsho	1967	3	expression	expression	NN
cord-006229-7yoilsho	1967	4	was	be	VBD
cord-006229-7yoilsho	1967	5	50	50	CD
cord-006229-7yoilsho	1967	6	±	±	NNP
cord-006229-7yoilsho	1967	7	9	9	CD
cord-006229-7yoilsho	1967	8	%	%	NN
cord-006229-7yoilsho	1967	9	of	of	IN
cord-006229-7yoilsho	1967	10	WT	WT	NNP
cord-006229-7yoilsho	1967	11	.	.	.
cord-006229-7yoilsho	1968	1	Renin	renin	NN
cord-006229-7yoilsho	1968	2	-	-	HYPH
cord-006229-7yoilsho	1968	3	expressing	express	VBG
cord-006229-7yoilsho	1968	4	cells	cell	NNS
cord-006229-7yoilsho	1968	5	were	be	VBD
cord-006229-7yoilsho	1968	6	located	locate	VBN
cord-006229-7yoilsho	1968	7	at	at	IN
cord-006229-7yoilsho	1968	8	the	the	DT
cord-006229-7yoilsho	1968	9	juxtaglomerular	juxtaglomerular	JJ
cord-006229-7yoilsho	1968	10	position	position	NN
cord-006229-7yoilsho	1968	11	and	and	CC
cord-006229-7yoilsho	1968	12	renal	renal	JJ
cord-006229-7yoilsho	1968	13	renin	renin	NN
cord-006229-7yoilsho	1968	14	protein	protein	NN
cord-006229-7yoilsho	1968	15	expression	expression	NN
cord-006229-7yoilsho	1968	16	was	be	VBD
cord-006229-7yoilsho	1968	17	lower	low	JJR
cord-006229-7yoilsho	1968	18	in	in	IN
cord-006229-7yoilsho	1968	19	PAR2-deficient	PAR2-deficient	NNP
cord-006229-7yoilsho	1968	20	mice	mouse	NNS
cord-006229-7yoilsho	1968	21	.	.	.
cord-006229-7yoilsho	1969	1	As	as	IN
cord-006229-7yoilsho	1969	2	measured	measure	VBN
cord-006229-7yoilsho	1969	3	by	by	IN
cord-006229-7yoilsho	1969	4	tail	tail	NN
cord-006229-7yoilsho	1969	5	-	-	HYPH
cord-006229-7yoilsho	1969	6	cuff	cuff	NN
cord-006229-7yoilsho	1969	7	method	method	NN
cord-006229-7yoilsho	1969	8	,	,	,
cord-006229-7yoilsho	1969	9	systolic	systolic	JJ
cord-006229-7yoilsho	1969	10	blood	blood	NN
cord-006229-7yoilsho	1969	11	pressure	pressure	NN
cord-006229-7yoilsho	1969	12	was	be	VBD
cord-006229-7yoilsho	1969	13	not	not	RB
cord-006229-7yoilsho	1969	14	different	different	JJ
cord-006229-7yoilsho	1969	15	between	between	IN
cord-006229-7yoilsho	1969	16	PAR2	PAR2	NNP
cord-006229-7yoilsho	1969	17	(	(	-LRB-
cord-006229-7yoilsho	1969	18	-/-	-/-	NNP
cord-006229-7yoilsho	1969	19	)	)	-RRB-
cord-006229-7yoilsho	1969	20	and	and	CC
cord-006229-7yoilsho	1969	21	WT	WT	NNP
cord-006229-7yoilsho	1969	22	mice	mouse	NNS
cord-006229-7yoilsho	1969	23	.	.	.
cord-006229-7yoilsho	1970	1	Administration	administration	NN
cord-006229-7yoilsho	1970	2	of	of	IN
cord-006229-7yoilsho	1970	3	SLIGRL	SLIGRL	NNP
cord-006229-7yoilsho	1970	4	increased	increase	VBD
cord-006229-7yoilsho	1970	5	renin	renin	NN
cord-006229-7yoilsho	1970	6	secretion	secretion	NN
cord-006229-7yoilsho	1970	7	about	about	IN
cord-006229-7yoilsho	1970	8	6-fold	6-fold	CD
cord-006229-7yoilsho	1970	9	(	(	-LRB-
cord-006229-7yoilsho	1970	10	p<0.01	p<0.01	NNP
cord-006229-7yoilsho	1970	11	)	)	-RRB-
cord-006229-7yoilsho	1970	12	.	.	.
cord-006229-7yoilsho	1971	1	Acute	acute	JJ
cord-006229-7yoilsho	1971	2	stimulation	stimulation	NN
cord-006229-7yoilsho	1971	3	of	of	IN
cord-006229-7yoilsho	1971	4	renin	renin	NN
cord-006229-7yoilsho	1971	5	release	release	NN
cord-006229-7yoilsho	1971	6	by	by	IN
cord-006229-7yoilsho	1971	7	furosemide	furosemide	NN
cord-006229-7yoilsho	1971	8	,	,	,
cord-006229-7yoilsho	1971	9	isoproterenol	isoproterenol	NNP
cord-006229-7yoilsho	1971	10	,	,	,
cord-006229-7yoilsho	1971	11	losartan	losartan	NNP
cord-006229-7yoilsho	1971	12	and	and	CC
cord-006229-7yoilsho	1971	13	hydralazine	hydralazine	NNP
cord-006229-7yoilsho	1971	14	caused	cause	VBD
cord-006229-7yoilsho	1971	15	significant	significant	JJ
cord-006229-7yoilsho	1971	16	increases	increase	NNS
cord-006229-7yoilsho	1971	17	of	of	IN
cord-006229-7yoilsho	1971	18	plasma	plasma	NN
cord-006229-7yoilsho	1971	19	renin	renin	NN
cord-006229-7yoilsho	1971	20	concentration	concentration	NN
cord-006229-7yoilsho	1971	21	in	in	IN
cord-006229-7yoilsho	1971	22	both	both	CC
cord-006229-7yoilsho	1971	23	PAR2	PAR2	NNP
cord-006229-7yoilsho	1971	24	(	(	-LRB-
cord-006229-7yoilsho	1971	25	-/-	-/-	NNP
cord-006229-7yoilsho	1971	26	)	)	-RRB-
cord-006229-7yoilsho	1971	27	and	and	CC
cord-006229-7yoilsho	1971	28	WT	WT	NNP
cord-006229-7yoilsho	1971	29	mice	mouse	NNS
cord-006229-7yoilsho	1971	30	.	.	.
cord-006229-7yoilsho	1972	1	The	the	DT
cord-006229-7yoilsho	1972	2	absolute	absolute	JJ
cord-006229-7yoilsho	1972	3	changes	change	NNS
cord-006229-7yoilsho	1972	4	(	(	-LRB-
cord-006229-7yoilsho	1972	5	Delta	Delta	NNP
cord-006229-7yoilsho	1972	6	PRC	PRC	NNP
cord-006229-7yoilsho	1972	7	)	)	-RRB-
cord-006229-7yoilsho	1972	8	were	be	VBD
cord-006229-7yoilsho	1972	9	similar	similar	JJ
cord-006229-7yoilsho	1972	10	(	(	-LRB-
cord-006229-7yoilsho	1972	11	3780	3780	CD
cord-006229-7yoilsho	1972	12	±	±	NNP
cord-006229-7yoilsho	1972	13	770	770	CD
cord-006229-7yoilsho	1972	14	,	,	,
cord-006229-7yoilsho	1973	1	2230	2230	CD
cord-006229-7yoilsho	1973	2	±	±	CD
cord-006229-7yoilsho	1973	3	400	400	CD
cord-006229-7yoilsho	1973	4	,	,	,
cord-006229-7yoilsho	1973	5	2780	2780	CD
cord-006229-7yoilsho	1973	6	±	±	CD
cord-006229-7yoilsho	1973	7	70	70	CD
cord-006229-7yoilsho	1973	8	,	,	,
cord-006229-7yoilsho	1973	9	1390	1390	CD
cord-006229-7yoilsho	1973	10	±	±	CD
cord-006229-7yoilsho	1973	11	460	460	CD
cord-006229-7yoilsho	1973	12	in	in	IN
cord-006229-7yoilsho	1973	13	WT	WT	NNP
cord-006229-7yoilsho	1973	14	,	,	,
cord-006229-7yoilsho	1973	15	and	and	CC
cord-006229-7yoilsho	1973	16	2320	2320	CD
cord-006229-7yoilsho	1973	17	±	±	CD
cord-006229-7yoilsho	1973	18	270	270	CD
cord-006229-7yoilsho	1973	19	,	,	,
cord-006229-7yoilsho	1973	20	2530	2530	CD
cord-006229-7yoilsho	1973	21	±	±	CD
cord-006229-7yoilsho	1973	22	250	250	CD
cord-006229-7yoilsho	1973	23	,	,	,
cord-006229-7yoilsho	1973	24	3010	3010	CD
cord-006229-7yoilsho	1973	25	±	±	CD
cord-006229-7yoilsho	1973	26	210	210	CD
cord-006229-7yoilsho	1973	27	,	,	,
cord-006229-7yoilsho	1973	28	1230	1230	CD
cord-006229-7yoilsho	1973	29	±	±	CD
cord-006229-7yoilsho	1973	30	470	470	CD
cord-006229-7yoilsho	1973	31	in	in	IN
cord-006229-7yoilsho	1973	32	PAR2	PAR2	NNP
cord-006229-7yoilsho	1973	33	(	(	-LRB-
cord-006229-7yoilsho	1973	34	-/-	-/-	NNP
cord-006229-7yoilsho	1973	35	)	)	-RRB-
cord-006229-7yoilsho	1973	36	)	)	-RRB-
cord-006229-7yoilsho	1973	37	.	.	.
cord-006229-7yoilsho	1974	1	In	in	IN
cord-006229-7yoilsho	1974	2	conclusion	conclusion	NN
cord-006229-7yoilsho	1974	3	,	,	,
cord-006229-7yoilsho	1974	4	chronic	chronic	JJ
cord-006229-7yoilsho	1974	5	absence	absence	NN
cord-006229-7yoilsho	1974	6	of	of	IN
cord-006229-7yoilsho	1974	7	PAR2	PAR2	NNP
cord-006229-7yoilsho	1974	8	reduces	reduce	VBZ
cord-006229-7yoilsho	1974	9	basal	basal	NN
cord-006229-7yoilsho	1974	10	renin	renin	NN
cord-006229-7yoilsho	1974	11	expression	expression	NN
cord-006229-7yoilsho	1974	12	and	and	CC
cord-006229-7yoilsho	1974	13	renin	renin	NN
cord-006229-7yoilsho	1974	14	release	release	NN
cord-006229-7yoilsho	1974	15	.	.	.
cord-006229-7yoilsho	1975	1	However	however	RB
cord-006229-7yoilsho	1975	2	,	,	,
cord-006229-7yoilsho	1975	3	PAR2-deficiency	PAR2-deficiency	NNP
cord-006229-7yoilsho	1975	4	does	do	VBZ
cord-006229-7yoilsho	1975	5	not	not	RB
cord-006229-7yoilsho	1975	6	alter	alter	VB
cord-006229-7yoilsho	1975	7	renin	renin	NN
cord-006229-7yoilsho	1975	8	release	release	NN
cord-006229-7yoilsho	1975	9	in	in	IN
cord-006229-7yoilsho	1975	10	response	response	NN
cord-006229-7yoilsho	1975	11	to	to	IN
cord-006229-7yoilsho	1975	12	typical	typical	JJ
cord-006229-7yoilsho	1975	13	stimuli	stimulus	NNS
cord-006229-7yoilsho	1975	14	for	for	IN
cord-006229-7yoilsho	1975	15	renin	renin	NN
cord-006229-7yoilsho	1975	16	secretion	secretion	NN
cord-006229-7yoilsho	1975	17	.	.	.
cord-006229-7yoilsho	1976	1	Therefore	therefore	RB
cord-006229-7yoilsho	1976	2	,	,	,
cord-006229-7yoilsho	1976	3	PAR2	PAR2	NNP
cord-006229-7yoilsho	1976	4	does	do	VBZ
cord-006229-7yoilsho	1976	5	not	not	RB
cord-006229-7yoilsho	1976	6	appear	appear	VB
cord-006229-7yoilsho	1976	7	to	to	TO
cord-006229-7yoilsho	1976	8	be	be	VB
cord-006229-7yoilsho	1976	9	a	a	DT
cord-006229-7yoilsho	1976	10	mandatory	mandatory	JJ
cord-006229-7yoilsho	1976	11	and	and	CC
cord-006229-7yoilsho	1976	12	specific	specific	JJ
cord-006229-7yoilsho	1976	13	requirement	requirement	NN
cord-006229-7yoilsho	1976	14	for	for	IN
cord-006229-7yoilsho	1976	15	acute	acute	JJ
cord-006229-7yoilsho	1976	16	regulatory	regulatory	JJ
cord-006229-7yoilsho	1976	17	responsiveness	responsiveness	NN
cord-006229-7yoilsho	1976	18	.	.	.
cord-006229-7yoilsho	1977	1	Increased	increase	VBN
cord-006229-7yoilsho	1977	2	myofilament	myofilament	NNP
cord-006229-7yoilsho	1978	1	Ca	ca	RB
cord-006229-7yoilsho	1979	1	2	2	LS
cord-006229-7yoilsho	1979	2	+	+	CC
cord-006229-7yoilsho	1979	3	sensitivity	sensitivity	NN
cord-006229-7yoilsho	1979	4	could	could	MD
cord-006229-7yoilsho	1979	5	be	be	VB
cord-006229-7yoilsho	1979	6	the	the	DT
cord-006229-7yoilsho	1979	7	underlying	underlying	JJ
cord-006229-7yoilsho	1979	8	cause	cause	NN
cord-006229-7yoilsho	1979	9	of	of	IN
cord-006229-7yoilsho	1979	10	diastolic	diastolic	JJ
cord-006229-7yoilsho	1979	11	dysfunction	dysfunction	NN
cord-006229-7yoilsho	1979	12	.	.	.
cord-006229-7yoilsho	1980	1	We	-PRON-	PRP
cord-006229-7yoilsho	1980	2	evaluated	evaluate	VBD
cord-006229-7yoilsho	1980	3	acute	acute	JJ
cord-006229-7yoilsho	1980	4	effects	effect	NNS
cord-006229-7yoilsho	1980	5	of	of	IN
cord-006229-7yoilsho	1980	6	epigallocatechin-3-gallate	epigallocatechin-3-gallate	JJ
cord-006229-7yoilsho	1980	7	(	(	-LRB-
cord-006229-7yoilsho	1980	8	EGCg	EGCg	NNS
cord-006229-7yoilsho	1980	9	)	)	-RRB-
cord-006229-7yoilsho	1980	10	,	,	,
cord-006229-7yoilsho	1980	11	which	which	WDT
cord-006229-7yoilsho	1980	12	has	have	VBZ
cord-006229-7yoilsho	1980	13	been	be	VBN
cord-006229-7yoilsho	1980	14	shown	show	VBN
cord-006229-7yoilsho	1980	15	to	to	TO
cord-006229-7yoilsho	1980	16	decrease	decrease	VB
cord-006229-7yoilsho	1980	17	myofilament	myofilament	NNP
cord-006229-7yoilsho	1981	1	Ca	ca	NN
cord-006229-7yoilsho	1981	2	2	2	CD
cord-006229-7yoilsho	1981	3	+	+	CC
cord-006229-7yoilsho	1981	4	sensitivity	sensitivity	NN
cord-006229-7yoilsho	1981	5	,	,	,
cord-006229-7yoilsho	1981	6	on	on	IN
cord-006229-7yoilsho	1981	7	cardiac	cardiac	JJ
cord-006229-7yoilsho	1981	8	myocyte	myocyte	NN
cord-006229-7yoilsho	1981	9	contractility	contractility	NN
cord-006229-7yoilsho	1981	10	and	and	CC
cord-006229-7yoilsho	1981	11	force-	force-	NN
cord-006229-7yoilsho	1982	1	Ca	ca	NN
cord-006229-7yoilsho	1982	2	2	2	CD
cord-006229-7yoilsho	1982	3	+	+	CC
cord-006229-7yoilsho	1982	4	relationship	relationship	NN
cord-006229-7yoilsho	1982	5	of	of	IN
cord-006229-7yoilsho	1982	6	skinned	skinned	JJ
cord-006229-7yoilsho	1982	7	cardiac	cardiac	JJ
cord-006229-7yoilsho	1982	8	muscle	muscle	NN
cord-006229-7yoilsho	1982	9	strips	strip	NNS
cord-006229-7yoilsho	1982	10	in	in	IN
cord-006229-7yoilsho	1982	11	an	an	DT
cord-006229-7yoilsho	1982	12	HCM	HCM	NNP
cord-006229-7yoilsho	1982	13	mouse	mouse	NN
cord-006229-7yoilsho	1982	14	model	model	NN
cord-006229-7yoilsho	1982	15	with	with	IN
cord-006229-7yoilsho	1982	16	left	left	JJ
cord-006229-7yoilsho	1982	17	ventricular	ventricular	JJ
cord-006229-7yoilsho	1982	18	hypertrophy	hypertrophy	NN
cord-006229-7yoilsho	1982	19	and	and	CC
cord-006229-7yoilsho	1982	20	both	both	CC
cord-006229-7yoilsho	1982	21	systolic	systolic	JJ
cord-006229-7yoilsho	1982	22	and	and	CC
cord-006229-7yoilsho	1982	23	diastolic	diastolic	JJ
cord-006229-7yoilsho	1982	24	dysfunction	dysfunction	NN
cord-006229-7yoilsho	1982	25	.	.	.
cord-006229-7yoilsho	1983	1	Methods	method	NNS
cord-006229-7yoilsho	1983	2	:	:	:
cord-006229-7yoilsho	1984	1	The	the	DT
cord-006229-7yoilsho	1984	2	HCM	HCM	NNP
cord-006229-7yoilsho	1984	3	mouse	mouse	NN
cord-006229-7yoilsho	1984	4	model	model	NN
cord-006229-7yoilsho	1984	5	used	use	VBN
cord-006229-7yoilsho	1984	6	in	in	IN
cord-006229-7yoilsho	1984	7	this	this	DT
cord-006229-7yoilsho	1984	8	study	study	NN
cord-006229-7yoilsho	1984	9	carries	carry	VBZ
cord-006229-7yoilsho	1984	10	a	a	DT
cord-006229-7yoilsho	1984	11	point	point	NN
cord-006229-7yoilsho	1984	12	mutation	mutation	NN
cord-006229-7yoilsho	1984	13	in	in	IN
cord-006229-7yoilsho	1984	14	the	the	DT
cord-006229-7yoilsho	1984	15	cardiac	cardiac	JJ
cord-006229-7yoilsho	1984	16	myosin	myosin	NN
cord-006229-7yoilsho	1984	17	-	-	HYPH
cord-006229-7yoilsho	1984	18	binding	bind	VBG
cord-006229-7yoilsho	1984	19	protein	protein	NN
cord-006229-7yoilsho	1984	20	C	c	NN
cord-006229-7yoilsho	1984	21	gene	gene	NN
cord-006229-7yoilsho	1984	22	at	at	IN
cord-006229-7yoilsho	1984	23	the	the	DT
cord-006229-7yoilsho	1984	24	homozygous	homozygous	JJ
cord-006229-7yoilsho	1984	25	state	state	NN
cord-006229-7yoilsho	1984	26	(	(	-LRB-
cord-006229-7yoilsho	1984	27	Mybpc3-targeted	Mybpc3-targeted	NNP
cord-006229-7yoilsho	1984	28	knock	knock	NN
cord-006229-7yoilsho	1984	29	-	-	HYPH
cord-006229-7yoilsho	1984	30	in	in	NN
cord-006229-7yoilsho	1984	31	;	;	:
cord-006229-7yoilsho	1984	32	KI	KI	NNP
cord-006229-7yoilsho	1984	33	)	)	-RRB-
cord-006229-7yoilsho	1984	34	.	.	.
cord-006229-7yoilsho	1985	1	We	-PRON-	PRP
cord-006229-7yoilsho	1985	2	isolated	isolate	VBD
cord-006229-7yoilsho	1985	3	ventricular	ventricular	JJ
cord-006229-7yoilsho	1985	4	myocytes	myocyte	NNS
cord-006229-7yoilsho	1985	5	from	from	IN
cord-006229-7yoilsho	1985	6	adult	adult	NN
cord-006229-7yoilsho	1985	7	KI	KI	NNP
cord-006229-7yoilsho	1985	8	and	and	CC
cord-006229-7yoilsho	1985	9	WT	WT	NNP
cord-006229-7yoilsho	1985	10	mice	mouse	NNS
cord-006229-7yoilsho	1985	11	and	and	CC
cord-006229-7yoilsho	1985	12	analyzed	analyze	VBD
cord-006229-7yoilsho	1985	13	sarcomere	sarcomere	NN
cord-006229-7yoilsho	1985	14	shortening	shortening	NN
cord-006229-7yoilsho	1985	15	and	and	CC
cord-006229-7yoilsho	1986	1	Ca	ca	NN
cord-006229-7yoilsho	1986	2	2	2	CD
cord-006229-7yoilsho	1986	3	+	+	SYM
cord-006229-7yoilsho	1986	4	transients	transient	NNS
cord-006229-7yoilsho	1986	5	at	at	IN
cord-006229-7yoilsho	1986	6	37	37	CD
cord-006229-7yoilsho	1986	7	°	°	NN
cord-006229-7yoilsho	1986	8	C	c	NN
cord-006229-7yoilsho	1987	1	under	under	IN
cord-006229-7yoilsho	1987	2	1	1	CD
cord-006229-7yoilsho	1987	3	Hz	Hz	NNP
cord-006229-7yoilsho	1987	4	pacing	pace	VBG
cord-006229-7yoilsho	1987	5	using	use	VBG
cord-006229-7yoilsho	1987	6	the	the	DT
cord-006229-7yoilsho	1987	7	IonOptix	IonOptix	NNP
cord-006229-7yoilsho	1987	8	system	system	NN
cord-006229-7yoilsho	1987	9	in	in	IN
cord-006229-7yoilsho	1987	10	the	the	DT
cord-006229-7yoilsho	1987	11	absence	absence	NN
cord-006229-7yoilsho	1987	12	or	or	CC
cord-006229-7yoilsho	1987	13	presence	presence	NN
cord-006229-7yoilsho	1987	14	of	of	IN
cord-006229-7yoilsho	1987	15	EGCg	EGCg	NNS
cord-006229-7yoilsho	1987	16	(	(	-LRB-
cord-006229-7yoilsho	1987	17	1.8	1.8	CD
cord-006229-7yoilsho	1987	18	µM	µm	NN
cord-006229-7yoilsho	1987	19	)	)	-RRB-
cord-006229-7yoilsho	1987	20	.	.	.
cord-006229-7yoilsho	1988	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	1988	2	,	,	,
cord-006229-7yoilsho	1988	3	force-	force-	XX
cord-006229-7yoilsho	1989	1	Ca	ca	NN
cord-006229-7yoilsho	1989	2	2	2	CD
cord-006229-7yoilsho	1989	3	+	+	SYM
cord-006229-7yoilsho	1989	4	relationships	relationship	NNS
cord-006229-7yoilsho	1989	5	of	of	IN
cord-006229-7yoilsho	1989	6	skinned	skinned	JJ
cord-006229-7yoilsho	1989	7	cardiac	cardiac	JJ
cord-006229-7yoilsho	1989	8	muscle	muscle	NN
cord-006229-7yoilsho	1989	9	strips	strip	NNS
cord-006229-7yoilsho	1989	10	of	of	IN
cord-006229-7yoilsho	1989	11	KI	KI	NNP
cord-006229-7yoilsho	1989	12	and	and	CC
cord-006229-7yoilsho	1989	13	WT	WT	NNP
cord-006229-7yoilsho	1989	14	mice	mouse	NNS
cord-006229-7yoilsho	1989	15	were	be	VBD
cord-006229-7yoilsho	1989	16	obtained	obtain	VBN
cord-006229-7yoilsho	1989	17	±EGCg	±EGCg	NNP
cord-006229-7yoilsho	1989	18	(	(	-LRB-
cord-006229-7yoilsho	1989	19	30	30	CD
cord-006229-7yoilsho	1989	20	µM	µm	NN
cord-006229-7yoilsho	1989	21	)	)	-RRB-
cord-006229-7yoilsho	1989	22	.	.	.
cord-006229-7yoilsho	1990	1	Results	result	NNS
cord-006229-7yoilsho	1990	2	:	:	:
cord-006229-7yoilsho	1991	1	In	in	IN
cord-006229-7yoilsho	1991	2	baseline	baseline	JJ
cord-006229-7yoilsho	1991	3	settings	setting	NNS
cord-006229-7yoilsho	1991	4	and	and	CC
cord-006229-7yoilsho	1991	5	absence	absence	NN
cord-006229-7yoilsho	1991	6	of	of	IN
cord-006229-7yoilsho	1991	7	Fura-2	Fura-2	NNP
cord-006229-7yoilsho	1991	8	,	,	,
cord-006229-7yoilsho	1991	9	KI	KI	NNP
cord-006229-7yoilsho	1991	10	cardiomyocytes	cardiomyocyte	NNS
cord-006229-7yoilsho	1991	11	displayed	display	VBD
cord-006229-7yoilsho	1991	12	higher	high	JJR
cord-006229-7yoilsho	1991	13	sarcomere	sarcomere	NN
cord-006229-7yoilsho	1991	14	shortening	shortening	NN
cord-006229-7yoilsho	1991	15	(	(	-LRB-
cord-006229-7yoilsho	1991	16	Type-1	type-1	NN
cord-006229-7yoilsho	1991	17	serine	serine	NN
cord-006229-7yoilsho	1991	18	/	/	SYM
cord-006229-7yoilsho	1991	19	threonine	threonine	NN
cord-006229-7yoilsho	1991	20	protein	protein	NN
cord-006229-7yoilsho	1991	21	phosphatase	phosphatase	NN
cord-006229-7yoilsho	1991	22	(	(	-LRB-
cord-006229-7yoilsho	1991	23	PP1	PP1	NNP
cord-006229-7yoilsho	1991	24	)	)	-RRB-
cord-006229-7yoilsho	1992	1	comprises	comprise	VBZ
cord-006229-7yoilsho	1992	2	a	a	DT
cord-006229-7yoilsho	1992	3	family	family	NN
cord-006229-7yoilsho	1992	4	of	of	IN
cord-006229-7yoilsho	1992	5	enzymes	enzyme	NNS
cord-006229-7yoilsho	1992	6	that	that	WDT
cord-006229-7yoilsho	1992	7	dephosphorylate	dephosphorylate	VBP
cord-006229-7yoilsho	1992	8	cardiac	cardiac	JJ
cord-006229-7yoilsho	1992	9	regulatory	regulatory	JJ
cord-006229-7yoilsho	1992	10	proteins	protein	NNS
cord-006229-7yoilsho	1992	11	,	,	,
cord-006229-7yoilsho	1992	12	thereby	thereby	RB
cord-006229-7yoilsho	1992	13	modulating	modulate	VBG
cord-006229-7yoilsho	1993	1	Ca	ca	NN
cord-006229-7yoilsho	1993	2	2	2	CD
cord-006229-7yoilsho	1993	3	+	+	CC
cord-006229-7yoilsho	1993	4	handling	handling	NN
cord-006229-7yoilsho	1993	5	and	and	CC
cord-006229-7yoilsho	1993	6	contractility	contractility	NN
cord-006229-7yoilsho	1993	7	.	.	.
cord-006229-7yoilsho	1994	1	All	all	DT
cord-006229-7yoilsho	1994	2	PP1	PP1	NNP
cord-006229-7yoilsho	1994	3	heterodimers	heterodimer	NNS
cord-006229-7yoilsho	1994	4	possess	possess	VBP
cord-006229-7yoilsho	1994	5	a	a	DT
cord-006229-7yoilsho	1994	6	catalytic	catalytic	JJ
cord-006229-7yoilsho	1994	7	subunit	subunit	NN
cord-006229-7yoilsho	1994	8	,	,	,
cord-006229-7yoilsho	1994	9	which	which	WDT
cord-006229-7yoilsho	1994	10	is	be	VBZ
cord-006229-7yoilsho	1994	11	selectively	selectively	RB
cord-006229-7yoilsho	1994	12	inhibited	inhibit	VBN
cord-006229-7yoilsho	1994	13	by	by	IN
cord-006229-7yoilsho	1994	14	inhibitor	inhibitor	NN
cord-006229-7yoilsho	1994	15	2	2	CD
cord-006229-7yoilsho	1994	16	(	(	-LRB-
cord-006229-7yoilsho	1994	17	I-2	I-2	NNP
cord-006229-7yoilsho	1994	18	)	)	-RRB-
cord-006229-7yoilsho	1994	19	.	.	.
cord-006229-7yoilsho	1995	1	It	-PRON-	PRP
cord-006229-7yoilsho	1995	2	has	have	VBZ
cord-006229-7yoilsho	1995	3	been	be	VBN
cord-006229-7yoilsho	1995	4	shown	show	VBN
cord-006229-7yoilsho	1995	5	by	by	IN
cord-006229-7yoilsho	1995	6	our	-PRON-	PRP$
cord-006229-7yoilsho	1995	7	group	group	NN
cord-006229-7yoilsho	1995	8	that	that	IN
cord-006229-7yoilsho	1995	9	the	the	DT
cord-006229-7yoilsho	1995	10	heart	heart	NN
cord-006229-7yoilsho	1995	11	-	-	HYPH
cord-006229-7yoilsho	1995	12	directed	direct	VBN
cord-006229-7yoilsho	1995	13	overexpression	overexpression	NN
cord-006229-7yoilsho	1995	14	of	of	IN
cord-006229-7yoilsho	1995	15	a	a	DT
cord-006229-7yoilsho	1995	16	truncated	truncated	JJ
cord-006229-7yoilsho	1995	17	,	,	,
cord-006229-7yoilsho	1995	18	constitutively	constitutively	RB
cord-006229-7yoilsho	1995	19	active	active	JJ
cord-006229-7yoilsho	1995	20	form	form	NN
cord-006229-7yoilsho	1995	21	of	of	IN
cord-006229-7yoilsho	1995	22	I-2	I-2	NNP
cord-006229-7yoilsho	1995	23	resulted	result	VBD
cord-006229-7yoilsho	1995	24	in	in	IN
cord-006229-7yoilsho	1995	25	an	an	DT
cord-006229-7yoilsho	1995	26	improved	improve	VBN
cord-006229-7yoilsho	1995	27	basal	basal	NN
cord-006229-7yoilsho	1996	1	Ca	ca	NN
cord-006229-7yoilsho	1996	2	2	2	CD
cord-006229-7yoilsho	1996	3	+	+	CC
cord-006229-7yoilsho	1996	4	handling	handling	NN
cord-006229-7yoilsho	1996	5	and	and	CC
cord-006229-7yoilsho	1996	6	contractility	contractility	NN
cord-006229-7yoilsho	1996	7	.	.	.
cord-006229-7yoilsho	1997	1	In	in	IN
cord-006229-7yoilsho	1997	2	contrast	contrast	NN
cord-006229-7yoilsho	1997	3	,	,	,
cord-006229-7yoilsho	1997	4	chronic	chronic	JJ
cord-006229-7yoilsho	1997	5	pressure	pressure	NN
cord-006229-7yoilsho	1997	6	overload	overload	NN
cord-006229-7yoilsho	1997	7	by	by	IN
cord-006229-7yoilsho	1997	8	transverse	transverse	JJ
cord-006229-7yoilsho	1997	9	aortic	aortic	JJ
cord-006229-7yoilsho	1997	10	constriction	constriction	NN
cord-006229-7yoilsho	1997	11	exacerbated	exacerbate	VBD
cord-006229-7yoilsho	1997	12	the	the	DT
cord-006229-7yoilsho	1997	13	progression	progression	NN
cord-006229-7yoilsho	1997	14	of	of	IN
cord-006229-7yoilsho	1997	15	cardiac	cardiac	JJ
cord-006229-7yoilsho	1997	16	remodeling	remodeling	NN
cord-006229-7yoilsho	1997	17	and	and	CC
cord-006229-7yoilsho	1997	18	heart	heart	NN
cord-006229-7yoilsho	1997	19	failure	failure	NN
cord-006229-7yoilsho	1997	20	in	in	IN
cord-006229-7yoilsho	1997	21	transgenic	transgenic	JJ
cord-006229-7yoilsho	1997	22	mice	mouse	NNS
cord-006229-7yoilsho	1997	23	.	.	.
cord-006229-7yoilsho	1998	1	In	in	IN
cord-006229-7yoilsho	1998	2	the	the	DT
cord-006229-7yoilsho	1998	3	present	present	JJ
cord-006229-7yoilsho	1998	4	study	study	NN
cord-006229-7yoilsho	1998	5	,	,	,
cord-006229-7yoilsho	1998	6	we	-PRON-	PRP
cord-006229-7yoilsho	1998	7	tested	test	VBD
cord-006229-7yoilsho	1998	8	whether	whether	IN
cord-006229-7yoilsho	1998	9	the	the	DT
cord-006229-7yoilsho	1998	10	overexpression	overexpression	NN
cord-006229-7yoilsho	1998	11	of	of	IN
cord-006229-7yoilsho	1998	12	a	a	DT
cord-006229-7yoilsho	1998	13	full	full	JJ
cord-006229-7yoilsho	1998	14	-	-	HYPH
cord-006229-7yoilsho	1998	15	length	length	NN
cord-006229-7yoilsho	1998	16	form	form	NN
cord-006229-7yoilsho	1998	17	of	of	IN
cord-006229-7yoilsho	1998	18	I-2	I-2	NNP
cord-006229-7yoilsho	1998	19	,	,	,
cord-006229-7yoilsho	1998	20	regulated	regulate	VBN
cord-006229-7yoilsho	1998	21	by	by	IN
cord-006229-7yoilsho	1998	22	GSK3-dependent	GSK3-dependent	NNP
cord-006229-7yoilsho	1998	23	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	1998	24	at	at	IN
cord-006229-7yoilsho	1998	25	Thr	Thr	NNP
cord-006229-7yoilsho	1998	26	72	72	CD
cord-006229-7yoilsho	1998	27	,	,	,
cord-006229-7yoilsho	1998	28	resulted	result	VBD
cord-006229-7yoilsho	1998	29	in	in	IN
cord-006229-7yoilsho	1998	30	comparable	comparable	JJ
cord-006229-7yoilsho	1998	31	functional	functional	JJ
cord-006229-7yoilsho	1998	32	alterations	alteration	NNS
cord-006229-7yoilsho	1998	33	using	use	VBG
cord-006229-7yoilsho	1998	34	a	a	DT
cord-006229-7yoilsho	1998	35	model	model	NN
cord-006229-7yoilsho	1998	36	of	of	IN
cord-006229-7yoilsho	1998	37	induced	induce	VBN
cord-006229-7yoilsho	1998	38	heart	heart	NN
cord-006229-7yoilsho	1998	39	failure	failure	NN
cord-006229-7yoilsho	1998	40	.	.	.
cord-006229-7yoilsho	1999	1	For	for	IN
cord-006229-7yoilsho	1999	2	this	this	DT
cord-006229-7yoilsho	1999	3	purpose	purpose	NN
cord-006229-7yoilsho	1999	4	transgenic	transgenic	JJ
cord-006229-7yoilsho	1999	5	(	(	-LRB-
cord-006229-7yoilsho	1999	6	TG	TG	NNP
cord-006229-7yoilsho	1999	7	)	)	-RRB-
cord-006229-7yoilsho	1999	8	and	and	CC
cord-006229-7yoilsho	1999	9	wild	wild	JJ
cord-006229-7yoilsho	1999	10	-	-	HYPH
cord-006229-7yoilsho	1999	11	type	type	NN
cord-006229-7yoilsho	1999	12	(	(	-LRB-
cord-006229-7yoilsho	1999	13	WT	WT	NNP
cord-006229-7yoilsho	1999	14	)	)	-RRB-
cord-006229-7yoilsho	1999	15	mice	mouse	NNS
cord-006229-7yoilsho	1999	16	were	be	VBD
cord-006229-7yoilsho	1999	17	subjected	subject	VBN
cord-006229-7yoilsho	1999	18	to	to	IN
cord-006229-7yoilsho	1999	19	chronic	chronic	JJ
cord-006229-7yoilsho	1999	20	application	application	NN
cord-006229-7yoilsho	1999	21	of	of	IN
cord-006229-7yoilsho	1999	22	isoprenaline	isoprenaline	NNP
cord-006229-7yoilsho	1999	23	(	(	-LRB-
cord-006229-7yoilsho	1999	24	ISO	ISO	NNP
cord-006229-7yoilsho	1999	25	,	,	,
cord-006229-7yoilsho	1999	26	30	30	CD
cord-006229-7yoilsho	1999	27	mg	mg	NN
cord-006229-7yoilsho	1999	28	/	/	SYM
cord-006229-7yoilsho	1999	29	kg	kg	NNP
cord-006229-7yoilsho	1999	30	/	/	SYM
cord-006229-7yoilsho	1999	31	d	d	NN
cord-006229-7yoilsho	1999	32	)	)	-RRB-
cord-006229-7yoilsho	1999	33	via	via	IN
cord-006229-7yoilsho	1999	34	osmotic	osmotic	JJ
cord-006229-7yoilsho	1999	35	minipumps	minipumps	NNP
cord-006229-7yoilsho	1999	36	.	.	.
cord-006229-7yoilsho	2000	1	ISO	iso	NN
cord-006229-7yoilsho	2000	2	-	-	HYPH
cord-006229-7yoilsho	2000	3	stimulated	stimulate	VBN
cord-006229-7yoilsho	2000	4	mice	mouse	NNS
cord-006229-7yoilsho	2000	5	were	be	VBD
cord-006229-7yoilsho	2000	6	compared	compare	VBN
cord-006229-7yoilsho	2000	7	to	to	IN
cord-006229-7yoilsho	2000	8	mice	mouse	NNS
cord-006229-7yoilsho	2000	9	treated	treat	VBN
cord-006229-7yoilsho	2000	10	with	with	IN
cord-006229-7yoilsho	2000	11	0.9	0.9	CD
cord-006229-7yoilsho	2000	12	%	%	NN
cord-006229-7yoilsho	2000	13	NaCl	nacl	NN
cord-006229-7yoilsho	2000	14	(	(	-LRB-
cord-006229-7yoilsho	2000	15	n=5	n=5	RB
cord-006229-7yoilsho	2000	16	)	)	-RRB-
cord-006229-7yoilsho	2000	17	.	.	.
cord-006229-7yoilsho	2001	1	After	after	IN
cord-006229-7yoilsho	2001	2	one	one	CD
cord-006229-7yoilsho	2001	3	week	week	NN
cord-006229-7yoilsho	2001	4	of	of	IN
cord-006229-7yoilsho	2001	5	ISO	ISO	NNP
cord-006229-7yoilsho	2001	6	administration	administration	NN
cord-006229-7yoilsho	2001	7	,	,	,
cord-006229-7yoilsho	2001	8	cardiac	cardiac	JJ
cord-006229-7yoilsho	2001	9	hypertrophy	hypertrophy	NN
cord-006229-7yoilsho	2001	10	was	be	VBD
cord-006229-7yoilsho	2001	11	comparable	comparable	JJ
cord-006229-7yoilsho	2001	12	in	in	IN
cord-006229-7yoilsho	2001	13	TG	TG	NNP
cord-006229-7yoilsho	2001	14	and	and	CC
cord-006229-7yoilsho	2001	15	WT	WT	NNP
cord-006229-7yoilsho	2001	16	.	.	.
cord-006229-7yoilsho	2002	1	Ca	ca	NN
cord-006229-7yoilsho	2002	2	2	2	CD
cord-006229-7yoilsho	2002	3	+	+	SYM
cord-006229-7yoilsho	2002	4	transients	transient	NNS
cord-006229-7yoilsho	2002	5	were	be	VBD
cord-006229-7yoilsho	2002	6	measured	measure	VBN
cord-006229-7yoilsho	2002	7	in	in	IN
cord-006229-7yoilsho	2002	8	isolated	isolate	VBN
cord-006229-7yoilsho	2002	9	,	,	,
cord-006229-7yoilsho	2002	10	indo-1-loaded	indo-1-loaded	NNP
cord-006229-7yoilsho	2002	11	myocytes	myocyte	NNS
cord-006229-7yoilsho	2002	12	.	.	.
cord-006229-7yoilsho	2003	1	The	the	DT
cord-006229-7yoilsho	2003	2	peak	peak	NN
cord-006229-7yoilsho	2003	3	amplitude	amplitude	NN
cord-006229-7yoilsho	2003	4	of	of	IN
cord-006229-7yoilsho	2004	1	[	[	-LRB-
cord-006229-7yoilsho	2004	2	Ca	Ca	NNP
cord-006229-7yoilsho	2004	3	]	]	-RRB-
cord-006229-7yoilsho	2005	1	i	i	PRP
cord-006229-7yoilsho	2005	2	was	be	VBD
cord-006229-7yoilsho	2005	3	reduced	reduce	VBN
cord-006229-7yoilsho	2005	4	by	by	IN
cord-006229-7yoilsho	2005	5	39	39	CD
cord-006229-7yoilsho	2005	6	%	%	NN
cord-006229-7yoilsho	2005	7	in	in	IN
cord-006229-7yoilsho	2005	8	TG	TG	NNP
cord-006229-7yoilsho	2005	9	NaCl	NaCl	NNP
cord-006229-7yoilsho	2005	10	compared	compare	VBN
cord-006229-7yoilsho	2005	11	to	to	IN
cord-006229-7yoilsho	2005	12	WT	WT	NNP
cord-006229-7yoilsho	2005	13	NaCl	NaCl	NNP
cord-006229-7yoilsho	2005	14	(	(	-LRB-
cord-006229-7yoilsho	2005	15	p<0.05	p<0.05	CD
cord-006229-7yoilsho	2005	16	)	)	-RRB-
cord-006229-7yoilsho	2005	17	,	,	,
cord-006229-7yoilsho	2005	18	whereas	whereas	IN
cord-006229-7yoilsho	2005	19	chronic	chronic	JJ
cord-006229-7yoilsho	2005	20	ISO	iso	NN
cord-006229-7yoilsho	2005	21	application	application	NN
cord-006229-7yoilsho	2005	22	was	be	VBD
cord-006229-7yoilsho	2005	23	associated	associate	VBN
cord-006229-7yoilsho	2005	24	with	with	IN
cord-006229-7yoilsho	2005	25	comparable	comparable	JJ
cord-006229-7yoilsho	2005	26	effects	effect	NNS
cord-006229-7yoilsho	2005	27	in	in	IN
cord-006229-7yoilsho	2005	28	TG	TG	NNP
cord-006229-7yoilsho	2005	29	and	and	CC
cord-006229-7yoilsho	2005	30	WT	WT	NNP
cord-006229-7yoilsho	2005	31	.	.	.
cord-006229-7yoilsho	2006	1	[	[	-LRB-
cord-006229-7yoilsho	2006	2	Ca	Ca	NNP
cord-006229-7yoilsho	2006	3	]	]	-RRB-
cord-006229-7yoilsho	2006	4	i	i	PRP
cord-006229-7yoilsho	2006	5	decay	decay	VBP
cord-006229-7yoilsho	2006	6	kinetics	kinetic	NNS
cord-006229-7yoilsho	2006	7	were	be	VBD
cord-006229-7yoilsho	2006	8	comparable	comparable	JJ
cord-006229-7yoilsho	2006	9	in	in	IN
cord-006229-7yoilsho	2006	10	NaCl	nacl	NN
cord-006229-7yoilsho	2006	11	-	-	HYPH
cord-006229-7yoilsho	2006	12	treated	treat	VBN
cord-006229-7yoilsho	2006	13	groups	group	NNS
cord-006229-7yoilsho	2006	14	but	but	CC
cord-006229-7yoilsho	2006	15	hastened	hasten	VBD
cord-006229-7yoilsho	2006	16	by	by	IN
cord-006229-7yoilsho	2006	17	25	25	CD
cord-006229-7yoilsho	2006	18	%	%	NN
cord-006229-7yoilsho	2006	19	in	in	IN
cord-006229-7yoilsho	2006	20	TG	TG	NNP
cord-006229-7yoilsho	2006	21	ISO	ISO	NNP
cord-006229-7yoilsho	2006	22	compared	compare	VBN
cord-006229-7yoilsho	2006	23	to	to	IN
cord-006229-7yoilsho	2006	24	WT	WT	NNP
cord-006229-7yoilsho	2006	25	ISO	ISO	NNP
cord-006229-7yoilsho	2006	26	(	(	-LRB-
cord-006229-7yoilsho	2006	27	p<0.05	p<0.05	CD
cord-006229-7yoilsho	2006	28	)	)	-RRB-
cord-006229-7yoilsho	2006	29	.	.	.
cord-006229-7yoilsho	2007	1	Consistently	consistently	RB
cord-006229-7yoilsho	2007	2	,	,	,
cord-006229-7yoilsho	2007	3	SR	SR	NNP
cord-006229-7yoilsho	2007	4	Ca	Ca	NNP
cord-006229-7yoilsho	2007	5	2	2	CD
cord-006229-7yoilsho	2007	6	+	+	CC
cord-006229-7yoilsho	2007	7	load	load	NN
cord-006229-7yoilsho	2007	8	was	be	VBD
cord-006229-7yoilsho	2007	9	diminished	diminish	VBN
cord-006229-7yoilsho	2007	10	by	by	IN
cord-006229-7yoilsho	2007	11	28	28	CD
cord-006229-7yoilsho	2007	12	%	%	NN
cord-006229-7yoilsho	2007	13	in	in	IN
cord-006229-7yoilsho	2007	14	TG	TG	NNP
cord-006229-7yoilsho	2007	15	NaCl	NaCl	NNP
cord-006229-7yoilsho	2007	16	compared	compare	VBN
cord-006229-7yoilsho	2007	17	to	to	IN
cord-006229-7yoilsho	2007	18	WT	WT	NNP
cord-006229-7yoilsho	2007	19	NaCl	NaCl	NNP
cord-006229-7yoilsho	2007	20	(	(	-LRB-
cord-006229-7yoilsho	2007	21	p<0.05	p<0.05	CD
cord-006229-7yoilsho	2007	22	)	)	-RRB-
cord-006229-7yoilsho	2007	23	.	.	.
cord-006229-7yoilsho	2008	1	Chronic	chronic	JJ
cord-006229-7yoilsho	2008	2	ISO	iso	NN
cord-006229-7yoilsho	2008	3	stimulation	stimulation	NN
cord-006229-7yoilsho	2008	4	led	lead	VBD
cord-006229-7yoilsho	2008	5	to	to	IN
cord-006229-7yoilsho	2008	6	an	an	DT
cord-006229-7yoilsho	2008	7	unchanged	unchanged	JJ
cord-006229-7yoilsho	2008	8	SR	SR	NNP
cord-006229-7yoilsho	2008	9	Ca	Ca	NNP
cord-006229-7yoilsho	2008	10	2	2	CD
cord-006229-7yoilsho	2008	11	+	+	CC
cord-006229-7yoilsho	2008	12	content	content	NN
cord-006229-7yoilsho	2008	13	in	in	IN
cord-006229-7yoilsho	2008	14	TG	TG	NNP
cord-006229-7yoilsho	2008	15	and	and	CC
cord-006229-7yoilsho	2008	16	WT	WT	NNP
cord-006229-7yoilsho	2008	17	myocytes	myocyte	NNS
cord-006229-7yoilsho	2008	18	.	.	.
cord-006229-7yoilsho	2009	1	Biochemical	biochemical	JJ
cord-006229-7yoilsho	2009	2	analyses	analysis	NNS
cord-006229-7yoilsho	2009	3	revealed	reveal	VBD
cord-006229-7yoilsho	2009	4	that	that	IN
cord-006229-7yoilsho	2009	5	chronic	chronic	JJ
cord-006229-7yoilsho	2009	6	βadrenergic	βadrenergic	NN
cord-006229-7yoilsho	2009	7	stimulation	stimulation	NN
cord-006229-7yoilsho	2009	8	was	be	VBD
cord-006229-7yoilsho	2009	9	accompanied	accompany	VBN
cord-006229-7yoilsho	2009	10	by	by	IN
cord-006229-7yoilsho	2009	11	a	a	DT
cord-006229-7yoilsho	2009	12	more	more	JJR
cord-006229-7yoilsho	2009	13	than	than	IN
cord-006229-7yoilsho	2009	14	4-fold	4-fold	CD
cord-006229-7yoilsho	2009	15	higher	high	JJR
cord-006229-7yoilsho	2009	16	phospholamban	phospholamban	NNS
cord-006229-7yoilsho	2009	17	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	2009	18	at	at	IN
cord-006229-7yoilsho	2009	19	Ser	Ser	NNP
cord-006229-7yoilsho	2009	20	16	16	CD
cord-006229-7yoilsho	2009	21	in	in	IN
cord-006229-7yoilsho	2009	22	TG	TG	NNP
cord-006229-7yoilsho	2009	23	(	(	-LRB-
cord-006229-7yoilsho	2009	24	p<0.05	p<0.05	CD
cord-006229-7yoilsho	2009	25	)	)	-RRB-
cord-006229-7yoilsho	2009	26	.	.	.
cord-006229-7yoilsho	2010	1	Thus	thus	RB
cord-006229-7yoilsho	2010	2	,	,	,
cord-006229-7yoilsho	2010	3	these	these	DT
cord-006229-7yoilsho	2010	4	findings	finding	NNS
cord-006229-7yoilsho	2010	5	suggest	suggest	VBP
cord-006229-7yoilsho	2010	6	that	that	IN
cord-006229-7yoilsho	2010	7	overexpression	overexpression	NN
cord-006229-7yoilsho	2010	8	of	of	IN
cord-006229-7yoilsho	2010	9	I-2	I-2	NNP
cord-006229-7yoilsho	2010	10	is	be	VBZ
cord-006229-7yoilsho	2010	11	able	able	JJ
cord-006229-7yoilsho	2010	12	to	to	TO
cord-006229-7yoilsho	2010	13	reduce	reduce	VB
cord-006229-7yoilsho	2010	14	the	the	DT
cord-006229-7yoilsho	2010	15	progression	progression	NN
cord-006229-7yoilsho	2010	16	of	of	IN
cord-006229-7yoilsho	2010	17	heart	heart	NN
cord-006229-7yoilsho	2010	18	failure	failure	NN
cord-006229-7yoilsho	2010	19	by	by	IN
cord-006229-7yoilsho	2010	20	an	an	DT
cord-006229-7yoilsho	2010	21	improvement	improvement	NN
cord-006229-7yoilsho	2010	22	of	of	IN
cord-006229-7yoilsho	2010	23	myocyte	myocyte	NNP
cord-006229-7yoilsho	2011	1	Ca	ca	NN
cord-006229-7yoilsho	2011	2	2	2	CD
cord-006229-7yoilsho	2011	3	+	+	CC
cord-006229-7yoilsho	2011	4	handling	handling	NN
cord-006229-7yoilsho	2011	5	.	.	.
cord-006229-7yoilsho	2012	1	The	the	DT
cord-006229-7yoilsho	2012	2	ligand	ligand	NN
cord-006229-7yoilsho	2012	3	-	-	HYPH
cord-006229-7yoilsho	2012	4	activated	activate	VBN
cord-006229-7yoilsho	2012	5	farnesoid	farnesoid	NNP
cord-006229-7yoilsho	2012	6	X	x	NN
cord-006229-7yoilsho	2012	7	receptor	receptor	NN
cord-006229-7yoilsho	2012	8	(	(	-LRB-
cord-006229-7yoilsho	2012	9	FXR	FXR	NNP
cord-006229-7yoilsho	2012	10	)	)	-RRB-
cord-006229-7yoilsho	2012	11	is	be	VBZ
cord-006229-7yoilsho	2012	12	a	a	DT
cord-006229-7yoilsho	2012	13	nuclear	nuclear	JJ
cord-006229-7yoilsho	2012	14	receptor	receptor	NN
cord-006229-7yoilsho	2012	15	highly	highly	RB
cord-006229-7yoilsho	2012	16	expressed	express	VBN
cord-006229-7yoilsho	2012	17	in	in	IN
cord-006229-7yoilsho	2012	18	gastrointestinal	gastrointestinal	JJ
cord-006229-7yoilsho	2012	19	and	and	CC
cord-006229-7yoilsho	2012	20	metabolic	metabolic	JJ
cord-006229-7yoilsho	2012	21	tissues	tissue	NNS
cord-006229-7yoilsho	2012	22	,	,	,
cord-006229-7yoilsho	2012	23	such	such	JJ
cord-006229-7yoilsho	2012	24	as	as	IN
cord-006229-7yoilsho	2012	25	the	the	DT
cord-006229-7yoilsho	2012	26	duodenum	duodenum	NN
cord-006229-7yoilsho	2012	27	,	,	,
cord-006229-7yoilsho	2012	28	jejunum	jejunum	NNS
cord-006229-7yoilsho	2012	29	,	,	,
cord-006229-7yoilsho	2012	30	ileum	ileum	NN
cord-006229-7yoilsho	2012	31	,	,	,
cord-006229-7yoilsho	2012	32	colon	colon	NN
cord-006229-7yoilsho	2012	33	and	and	CC
cord-006229-7yoilsho	2012	34	the	the	DT
cord-006229-7yoilsho	2012	35	liver	liver	NN
cord-006229-7yoilsho	2012	36	,	,	,
cord-006229-7yoilsho	2012	37	but	but	CC
cord-006229-7yoilsho	2012	38	also	also	RB
cord-006229-7yoilsho	2012	39	in	in	IN
cord-006229-7yoilsho	2012	40	lower	low	JJR
cord-006229-7yoilsho	2012	41	amounts	amount	NNS
cord-006229-7yoilsho	2012	42	for	for	IN
cord-006229-7yoilsho	2012	43	instance	instance	NN
cord-006229-7yoilsho	2012	44	in	in	IN
cord-006229-7yoilsho	2012	45	macrophages	macrophage	NNS
cord-006229-7yoilsho	2012	46	.	.	.
cord-006229-7yoilsho	2013	1	The	the	DT
cord-006229-7yoilsho	2013	2	endogenous	endogenous	JJ
cord-006229-7yoilsho	2013	3	agonists	agonist	NNS
cord-006229-7yoilsho	2013	4	for	for	IN
cord-006229-7yoilsho	2013	5	this	this	DT
cord-006229-7yoilsho	2013	6	receptor	receptor	NN
cord-006229-7yoilsho	2013	7	are	be	VBP
cord-006229-7yoilsho	2013	8	bile	bile	NN
cord-006229-7yoilsho	2013	9	acids	acid	NNS
cord-006229-7yoilsho	2013	10	with	with	IN
cord-006229-7yoilsho	2013	11	the	the	DT
cord-006229-7yoilsho	2013	12	primary	primary	JJ
cord-006229-7yoilsho	2013	13	bile	bile	NN
cord-006229-7yoilsho	2013	14	acid	acid	NN
cord-006229-7yoilsho	2013	15	chenodeoxycholic	chenodeoxycholic	NN
cord-006229-7yoilsho	2013	16	acid	acid	NN
cord-006229-7yoilsho	2013	17	as	as	IN
cord-006229-7yoilsho	2013	18	the	the	DT
cord-006229-7yoilsho	2013	19	most	most	RBS
cord-006229-7yoilsho	2013	20	active	active	JJ
cord-006229-7yoilsho	2013	21	one	one	CD
cord-006229-7yoilsho	2013	22	.	.	.
cord-006229-7yoilsho	2014	1	Activation	activation	NN
cord-006229-7yoilsho	2014	2	of	of	IN
cord-006229-7yoilsho	2014	3	FXR	FXR	NNP
cord-006229-7yoilsho	2014	4	regulates	regulate	VBZ
cord-006229-7yoilsho	2014	5	the	the	DT
cord-006229-7yoilsho	2014	6	transcription	transcription	NN
cord-006229-7yoilsho	2014	7	of	of	IN
cord-006229-7yoilsho	2014	8	target	target	NN
cord-006229-7yoilsho	2014	9	genes	gene	NNS
cord-006229-7yoilsho	2014	10	relevant	relevant	JJ
cord-006229-7yoilsho	2014	11	in	in	IN
cord-006229-7yoilsho	2014	12	bile	bile	NN
cord-006229-7yoilsho	2014	13	acid	acid	NN
cord-006229-7yoilsho	2014	14	homeostasis	homeostasis	NN
cord-006229-7yoilsho	2014	15	,	,	,
cord-006229-7yoilsho	2014	16	glucose	glucose	NN
cord-006229-7yoilsho	2014	17	and	and	CC
cord-006229-7yoilsho	2014	18	lipid	lipid	NN
cord-006229-7yoilsho	2014	19	metabolism	metabolism	NN
cord-006229-7yoilsho	2014	20	,	,	,
cord-006229-7yoilsho	2014	21	liver	liver	NN
cord-006229-7yoilsho	2014	22	protection	protection	NN
cord-006229-7yoilsho	2014	23	,	,	,
cord-006229-7yoilsho	2014	24	inflammation	inflammation	NN
cord-006229-7yoilsho	2014	25	,	,	,
cord-006229-7yoilsho	2014	26	and	and	CC
cord-006229-7yoilsho	2014	27	cancerogenesis	cancerogenesis	NNP
cord-006229-7yoilsho	2014	28	.	.	.
cord-006229-7yoilsho	2015	1	Agonists	agonist	NNS
cord-006229-7yoilsho	2015	2	for	for	IN
cord-006229-7yoilsho	2015	3	FXR	FXR	NNP
cord-006229-7yoilsho	2015	4	have	have	VBP
cord-006229-7yoilsho	2015	5	been	be	VBN
cord-006229-7yoilsho	2015	6	discussed	discuss	VBN
cord-006229-7yoilsho	2015	7	as	as	IN
cord-006229-7yoilsho	2015	8	possible	possible	JJ
cord-006229-7yoilsho	2015	9	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	2015	10	options	option	NNS
cord-006229-7yoilsho	2015	11	for	for	IN
cord-006229-7yoilsho	2015	12	the	the	DT
cord-006229-7yoilsho	2015	13	treatment	treatment	NN
cord-006229-7yoilsho	2015	14	of	of	IN
cord-006229-7yoilsho	2015	15	obesity	obesity	NN
cord-006229-7yoilsho	2015	16	and	and	CC
cord-006229-7yoilsho	2015	17	the	the	DT
cord-006229-7yoilsho	2015	18	metabolic	metabolic	JJ
cord-006229-7yoilsho	2015	19	syndrome	syndrome	NN
cord-006229-7yoilsho	2015	20	.	.	.
cord-006229-7yoilsho	2016	1	Atherosclerosis	atherosclerosis	NN
cord-006229-7yoilsho	2016	2	is	be	VBZ
cord-006229-7yoilsho	2016	3	the	the	DT
cord-006229-7yoilsho	2016	4	main	main	JJ
cord-006229-7yoilsho	2016	5	pathology	pathology	NN
cord-006229-7yoilsho	2016	6	underlying	underlie	VBG
cord-006229-7yoilsho	2016	7	cardiovasular	cardiovasular	JJ
cord-006229-7yoilsho	2016	8	diseases	disease	NNS
cord-006229-7yoilsho	2016	9	and	and	CC
cord-006229-7yoilsho	2016	10	often	often	RB
cord-006229-7yoilsho	2016	11	occurs	occur	VBZ
cord-006229-7yoilsho	2016	12	side	side	NN
cord-006229-7yoilsho	2016	13	-	-	HYPH
cord-006229-7yoilsho	2016	14	by	by	IN
cord-006229-7yoilsho	2016	15	-	-	HYPH
cord-006229-7yoilsho	2016	16	side	side	NN
cord-006229-7yoilsho	2016	17	with	with	IN
cord-006229-7yoilsho	2016	18	the	the	DT
cord-006229-7yoilsho	2016	19	metabolic	metabolic	JJ
cord-006229-7yoilsho	2016	20	syndrome	syndrome	NN
cord-006229-7yoilsho	2016	21	.	.	.
cord-006229-7yoilsho	2017	1	Cholesterol	cholesterol	NN
cord-006229-7yoilsho	2017	2	deposition	deposition	NN
cord-006229-7yoilsho	2017	3	and	and	CC
cord-006229-7yoilsho	2017	4	the	the	DT
cord-006229-7yoilsho	2017	5	formation	formation	NN
cord-006229-7yoilsho	2017	6	of	of	IN
cord-006229-7yoilsho	2017	7	cholesterol	cholesterol	NN
cord-006229-7yoilsho	2017	8	-	-	HYPH
cord-006229-7yoilsho	2017	9	loaded	load	VBN
cord-006229-7yoilsho	2017	10	foam	foam	NN
cord-006229-7yoilsho	2017	11	cells	cell	NNS
cord-006229-7yoilsho	2017	12	from	from	IN
cord-006229-7yoilsho	2017	13	macrophages	macrophage	NNS
cord-006229-7yoilsho	2017	14	lead	lead	VBP
cord-006229-7yoilsho	2017	15	to	to	IN
cord-006229-7yoilsho	2017	16	the	the	DT
cord-006229-7yoilsho	2017	17	formation	formation	NN
cord-006229-7yoilsho	2017	18	of	of	IN
cord-006229-7yoilsho	2017	19	atherosclerotic	atherosclerotic	JJ
cord-006229-7yoilsho	2017	20	plaques	plaque	NNS
cord-006229-7yoilsho	2017	21	.	.	.
cord-006229-7yoilsho	2018	1	This	this	DT
cord-006229-7yoilsho	2018	2	can	can	MD
cord-006229-7yoilsho	2018	3	be	be	VB
cord-006229-7yoilsho	2018	4	prevented	prevent	VBN
cord-006229-7yoilsho	2018	5	by	by	IN
cord-006229-7yoilsho	2018	6	stimulation	stimulation	NN
cord-006229-7yoilsho	2018	7	of	of	IN
cord-006229-7yoilsho	2018	8	cholesterol	cholesterol	NN
cord-006229-7yoilsho	2018	9	efflux	efflux	NN
cord-006229-7yoilsho	2018	10	from	from	IN
cord-006229-7yoilsho	2018	11	macrophages	macrophage	NNS
cord-006229-7yoilsho	2018	12	.	.	.
cord-006229-7yoilsho	2019	1	Based	base	VBN
cord-006229-7yoilsho	2019	2	on	on	IN
cord-006229-7yoilsho	2019	3	leoligin	leoligin	NNP
cord-006229-7yoilsho	2019	4	,	,	,
cord-006229-7yoilsho	2019	5	a	a	DT
cord-006229-7yoilsho	2019	6	lignan	lignan	JJ
cord-006229-7yoilsho	2019	7	-	-	HYPH
cord-006229-7yoilsho	2019	8	type	type	NN
cord-006229-7yoilsho	2019	9	secondary	secondary	JJ
cord-006229-7yoilsho	2019	10	plant	plant	NN
cord-006229-7yoilsho	2019	11	metabolite	metabolite	NN
cord-006229-7yoilsho	2019	12	,	,	,
cord-006229-7yoilsho	2019	13	naturally	naturally	RB
cord-006229-7yoilsho	2019	14	occuring	occur	VBG
cord-006229-7yoilsho	2019	15	in	in	IN
cord-006229-7yoilsho	2019	16	Leontopodium	Leontopodium	NNP
cord-006229-7yoilsho	2019	17	alpinum	alpinum	NNP
cord-006229-7yoilsho	2019	18	Cass	Cass	NNP
cord-006229-7yoilsho	2019	19	.	.	.
cord-006229-7yoilsho	2020	1	,	,	,
cord-006229-7yoilsho	2020	2	168	168	CD
cord-006229-7yoilsho	2020	3	derivatives	derivative	NNS
cord-006229-7yoilsho	2020	4	were	be	VBD
cord-006229-7yoilsho	2020	5	synthesized	synthesize	VBN
cord-006229-7yoilsho	2020	6	and	and	CC
cord-006229-7yoilsho	2020	7	subjected	subject	VBN
cord-006229-7yoilsho	2020	8	to	to	IN
cord-006229-7yoilsho	2020	9	a	a	DT
cord-006229-7yoilsho	2020	10	FXR	FXR	NNP
cord-006229-7yoilsho	2020	11	pharmacophore	pharmacophore	NN
cord-006229-7yoilsho	2020	12	-	-	HYPH
cord-006229-7yoilsho	2020	13	based	base	VBN
cord-006229-7yoilsho	2020	14	in	in	IN
cord-006229-7yoilsho	2020	15	silico	silico	NN
cord-006229-7yoilsho	2020	16	screening	screening	NN
cord-006229-7yoilsho	2020	17	.	.	.
cord-006229-7yoilsho	2021	1	Testing	testing	NN
cord-006229-7yoilsho	2021	2	of	of	IN
cord-006229-7yoilsho	2021	3	56	56	CD
cord-006229-7yoilsho	2021	4	virtual	virtual	JJ
cord-006229-7yoilsho	2021	5	hits	hit	NNS
cord-006229-7yoilsho	2021	6	in	in	IN
cord-006229-7yoilsho	2021	7	a	a	DT
cord-006229-7yoilsho	2021	8	luciferase	luciferase	NN
cord-006229-7yoilsho	2021	9	-	-	HYPH
cord-006229-7yoilsho	2021	10	based	base	VBN
cord-006229-7yoilsho	2021	11	FXR	FXR	NNP
cord-006229-7yoilsho	2021	12	transactivation	transactivation	NN
cord-006229-7yoilsho	2021	13	assay	assay	NN
cord-006229-7yoilsho	2021	14	yielded	yield	VBD
cord-006229-7yoilsho	2021	15	one	one	CD
cord-006229-7yoilsho	2021	16	compound	compound	NN
cord-006229-7yoilsho	2021	17	with	with	IN
cord-006229-7yoilsho	2021	18	promising	promising	JJ
cord-006229-7yoilsho	2021	19	activity	activity	NN
cord-006229-7yoilsho	2021	20	on	on	IN
cord-006229-7yoilsho	2021	21	FXR	FXR	NNP
cord-006229-7yoilsho	2021	22	.	.	.
cord-006229-7yoilsho	2022	1	Moreover	moreover	RB
cord-006229-7yoilsho	2022	2	,	,	,
cord-006229-7yoilsho	2022	3	the	the	DT
cord-006229-7yoilsho	2022	4	heterodimer	heterodimer	NN
cord-006229-7yoilsho	2022	5	partner	partner	NN
cord-006229-7yoilsho	2022	6	of	of	IN
cord-006229-7yoilsho	2022	7	FXR	FXR	NNP
cord-006229-7yoilsho	2022	8	,	,	,
cord-006229-7yoilsho	2022	9	RXRα	RXRα	NNS
cord-006229-7yoilsho	2022	10	,	,	,
cord-006229-7yoilsho	2022	11	was	be	VBD
cord-006229-7yoilsho	2022	12	not	not	RB
cord-006229-7yoilsho	2022	13	activated	activate	VBN
cord-006229-7yoilsho	2022	14	by	by	IN
cord-006229-7yoilsho	2022	15	this	this	DT
cord-006229-7yoilsho	2022	16	leoligin	leoligin	NN
cord-006229-7yoilsho	2022	17	derivative	derivative	JJ
cord-006229-7yoilsho	2022	18	in	in	IN
cord-006229-7yoilsho	2022	19	a	a	DT
cord-006229-7yoilsho	2022	20	luciferase	luciferase	NN
cord-006229-7yoilsho	2022	21	-	-	HYPH
cord-006229-7yoilsho	2022	22	based	base	VBN
cord-006229-7yoilsho	2022	23	RXRα	RXRα	NNS
cord-006229-7yoilsho	2022	24	assay	assay	NN
cord-006229-7yoilsho	2022	25	.	.	.
cord-006229-7yoilsho	2023	1	In	in	IN
cord-006229-7yoilsho	2023	2	addition	addition	NN
cord-006229-7yoilsho	2023	3	,	,	,
cord-006229-7yoilsho	2023	4	this	this	DT
cord-006229-7yoilsho	2023	5	compound	compound	NN
cord-006229-7yoilsho	2023	6	was	be	VBD
cord-006229-7yoilsho	2023	7	able	able	JJ
cord-006229-7yoilsho	2023	8	to	to	TO
cord-006229-7yoilsho	2023	9	increase	increase	VB
cord-006229-7yoilsho	2023	10	cholesterol	cholesterol	NN
cord-006229-7yoilsho	2023	11	efflux	efflux	NN
cord-006229-7yoilsho	2023	12	in	in	IN
cord-006229-7yoilsho	2023	13	THP-1	THP-1	NNP
cord-006229-7yoilsho	2023	14	macrophages	macrophage	NNS
cord-006229-7yoilsho	2023	15	without	without	IN
cord-006229-7yoilsho	2023	16	affecting	affect	VBG
cord-006229-7yoilsho	2023	17	cell	cell	NN
cord-006229-7yoilsho	2023	18	viability	viability	NN
cord-006229-7yoilsho	2023	19	.	.	.
cord-006229-7yoilsho	2024	1	Western	western	JJ
cord-006229-7yoilsho	2024	2	blot	blot	NN
cord-006229-7yoilsho	2024	3	experiments	experiment	NNS
cord-006229-7yoilsho	2024	4	revealed	reveal	VBD
cord-006229-7yoilsho	2024	5	an	an	DT
cord-006229-7yoilsho	2024	6	increase	increase	NN
cord-006229-7yoilsho	2024	7	in	in	IN
cord-006229-7yoilsho	2024	8	ATP	ATP	NNP
cord-006229-7yoilsho	2024	9	-	-	HYPH
cord-006229-7yoilsho	2024	10	binding	bind	VBG
cord-006229-7yoilsho	2024	11	cassette	cassette	NN
cord-006229-7yoilsho	2024	12	transporter	transporter	NN
cord-006229-7yoilsho	2024	13	A1	a1	NN
cord-006229-7yoilsho	2024	14	(	(	-LRB-
cord-006229-7yoilsho	2024	15	ABCA1	abca1	NN
cord-006229-7yoilsho	2024	16	)	)	-RRB-
cord-006229-7yoilsho	2024	17	expression	expression	NN
cord-006229-7yoilsho	2024	18	in	in	IN
cord-006229-7yoilsho	2024	19	human	human	JJ
cord-006229-7yoilsho	2024	20	THP-1	THP-1	NNP
cord-006229-7yoilsho	2024	21	macrophages	macrophage	NNS
cord-006229-7yoilsho	2024	22	by	by	IN
cord-006229-7yoilsho	2024	23	this	this	DT
cord-006229-7yoilsho	2024	24	leoligin	leoligin	NN
cord-006229-7yoilsho	2024	25	derivative	derivative	JJ
cord-006229-7yoilsho	2024	26	.	.	.
cord-006229-7yoilsho	2025	1	The	the	DT
cord-006229-7yoilsho	2025	2	transporters	transporter	NNS
cord-006229-7yoilsho	2025	3	ABCG1	abcg1	VBP
cord-006229-7yoilsho	2025	4	and	and	CC
cord-006229-7yoilsho	2025	5	scavenger	scavenger	NN
cord-006229-7yoilsho	2025	6	receptor	receptor	NN
cord-006229-7yoilsho	2025	7	class	class	NN
cord-006229-7yoilsho	2025	8	B	b	NN
cord-006229-7yoilsho	2025	9	(	(	-LRB-
cord-006229-7yoilsho	2025	10	SR	SR	NNP
cord-006229-7yoilsho	2025	11	-	-	HYPH
cord-006229-7yoilsho	2025	12	BI	BI	NNP
cord-006229-7yoilsho	2025	13	)	)	-RRB-
cord-006229-7yoilsho	2025	14	,	,	,
cord-006229-7yoilsho	2025	15	which	which	WDT
cord-006229-7yoilsho	2025	16	also	also	RB
cord-006229-7yoilsho	2025	17	play	play	VBP
cord-006229-7yoilsho	2025	18	a	a	DT
cord-006229-7yoilsho	2025	19	key	key	JJ
cord-006229-7yoilsho	2025	20	role	role	NN
cord-006229-7yoilsho	2025	21	in	in	IN
cord-006229-7yoilsho	2025	22	macrophage	macrophage	NN
cord-006229-7yoilsho	2025	23	cholesterol	cholesterol	NN
cord-006229-7yoilsho	2025	24	efflux	efflux	NN
cord-006229-7yoilsho	2025	25	,	,	,
cord-006229-7yoilsho	2025	26	will	will	MD
cord-006229-7yoilsho	2025	27	be	be	VB
cord-006229-7yoilsho	2025	28	investigated	investigate	VBN
cord-006229-7yoilsho	2025	29	.	.	.
cord-006229-7yoilsho	2026	1	Moreover	moreover	RB
cord-006229-7yoilsho	2026	2	,	,	,
cord-006229-7yoilsho	2026	3	the	the	DT
cord-006229-7yoilsho	2026	4	effect	effect	NN
cord-006229-7yoilsho	2026	5	of	of	IN
cord-006229-7yoilsho	2026	6	the	the	DT
cord-006229-7yoilsho	2026	7	leoligin	leoligin	NN
cord-006229-7yoilsho	2026	8	derivative	derivative	JJ
cord-006229-7yoilsho	2026	9	on	on	IN
cord-006229-7yoilsho	2026	10	liver	liver	NN
cord-006229-7yoilsho	2026	11	X	x	NN
cord-006229-7yoilsho	2026	12	receptor	receptor	NN
cord-006229-7yoilsho	2026	13	activation	activation	NN
cord-006229-7yoilsho	2026	14	,	,	,
cord-006229-7yoilsho	2026	15	the	the	DT
cord-006229-7yoilsho	2026	16	nuclear	nuclear	JJ
cord-006229-7yoilsho	2026	17	receptor	receptor	NN
cord-006229-7yoilsho	2026	18	responsible	responsible	JJ
cord-006229-7yoilsho	2026	19	for	for	IN
cord-006229-7yoilsho	2026	20	upregulation	upregulation	NN
cord-006229-7yoilsho	2026	21	of	of	IN
cord-006229-7yoilsho	2026	22	these	these	DT
cord-006229-7yoilsho	2026	23	transporters	transporter	NNS
cord-006229-7yoilsho	2026	24	,	,	,
cord-006229-7yoilsho	2026	25	has	have	VBZ
cord-006229-7yoilsho	2026	26	to	to	TO
cord-006229-7yoilsho	2026	27	be	be	VB
cord-006229-7yoilsho	2026	28	studied	study	VBN
cord-006229-7yoilsho	2026	29	.	.	.
cord-006229-7yoilsho	2027	1	Based	base	VBN
cord-006229-7yoilsho	2027	2	on	on	IN
cord-006229-7yoilsho	2027	3	this	this	DT
cord-006229-7yoilsho	2027	4	data	datum	NNS
cord-006229-7yoilsho	2027	5	,	,	,
cord-006229-7yoilsho	2027	6	further	further	JJ
cord-006229-7yoilsho	2027	7	characterization	characterization	NN
cord-006229-7yoilsho	2027	8	of	of	IN
cord-006229-7yoilsho	2027	9	the	the	DT
cord-006229-7yoilsho	2027	10	molecular	molecular	JJ
cord-006229-7yoilsho	2027	11	mechanism	mechanism	NN
cord-006229-7yoilsho	2027	12	underlying	underlie	VBG
cord-006229-7yoilsho	2027	13	the	the	DT
cord-006229-7yoilsho	2027	14	described	describe	VBN
cord-006229-7yoilsho	2027	15	effects	effect	NNS
cord-006229-7yoilsho	2027	16	will	will	MD
cord-006229-7yoilsho	2027	17	provide	provide	VB
cord-006229-7yoilsho	2027	18	valuable	valuable	JJ
cord-006229-7yoilsho	2027	19	insights	insight	NNS
cord-006229-7yoilsho	2027	20	in	in	IN
cord-006229-7yoilsho	2027	21	a	a	DT
cord-006229-7yoilsho	2027	22	possible	possible	JJ
cord-006229-7yoilsho	2027	23	crosstalk	crosstalk	NN
cord-006229-7yoilsho	2027	24	between	between	IN
cord-006229-7yoilsho	2027	25	macrophage	macrophage	NN
cord-006229-7yoilsho	2027	26	cholesterol	cholesterol	NN
cord-006229-7yoilsho	2027	27	efflux	efflux	NN
cord-006229-7yoilsho	2027	28	and	and	CC
cord-006229-7yoilsho	2027	29	FXR	FXR	NNP
cord-006229-7yoilsho	2027	30	activation	activation	NN
cord-006229-7yoilsho	2027	31	.	.	.
cord-006229-7yoilsho	2028	1	Background	background	NN
cord-006229-7yoilsho	2028	2	:	:	:
cord-006229-7yoilsho	2029	1	Rho	rho	NN
cord-006229-7yoilsho	2029	2	-	-	HYPH
cord-006229-7yoilsho	2029	3	associated	associate	VBN
cord-006229-7yoilsho	2029	4	kinases	kinase	NNS
cord-006229-7yoilsho	2030	1	ROCK1	rock1	XX
cord-006229-7yoilsho	2031	1	and	and	CC
cord-006229-7yoilsho	2031	2	ROCK2	rock2	NN
cord-006229-7yoilsho	2031	3	are	be	VBP
cord-006229-7yoilsho	2032	1	serine	serine	NN
cord-006229-7yoilsho	2032	2	/	/	SYM
cord-006229-7yoilsho	2032	3	threonine	threonine	NN
cord-006229-7yoilsho	2032	4	kinases	kinase	NNS
cord-006229-7yoilsho	2032	5	that	that	WDT
cord-006229-7yoilsho	2032	6	are	be	VBP
cord-006229-7yoilsho	2032	7	downstream	downstream	JJ
cord-006229-7yoilsho	2032	8	targets	target	NNS
cord-006229-7yoilsho	2032	9	of	of	IN
cord-006229-7yoilsho	2032	10	the	the	DT
cord-006229-7yoilsho	2032	11	small	small	JJ
cord-006229-7yoilsho	2032	12	GTPases	gtpase	NNS
cord-006229-7yoilsho	2032	13	RhoA	RhoA	NNP
cord-006229-7yoilsho	2032	14	,	,	,
cord-006229-7yoilsho	2032	15	RhoB	RhoB	NNP
cord-006229-7yoilsho	2032	16	,	,	,
cord-006229-7yoilsho	2032	17	and	and	CC
cord-006229-7yoilsho	2032	18	RhoC.	RhoC.	NNP
cord-006229-7yoilsho	2032	19	ROCK1	ROCK1	NNP
cord-006229-7yoilsho	2032	20	and	and	CC
cord-006229-7yoilsho	2032	21	ROCK2	ROCK2	NNP
cord-006229-7yoilsho	2032	22	are	be	VBP
cord-006229-7yoilsho	2032	23	known	know	VBN
cord-006229-7yoilsho	2032	24	to	to	TO
cord-006229-7yoilsho	2032	25	play	play	VB
cord-006229-7yoilsho	2032	26	a	a	DT
cord-006229-7yoilsho	2032	27	pivotal	pivotal	JJ
cord-006229-7yoilsho	2032	28	role	role	NN
cord-006229-7yoilsho	2032	29	in	in	IN
cord-006229-7yoilsho	2032	30	the	the	DT
cord-006229-7yoilsho	2032	31	pathogenesis	pathogenesis	NN
cord-006229-7yoilsho	2032	32	of	of	IN
cord-006229-7yoilsho	2032	33	myocardial	myocardial	JJ
cord-006229-7yoilsho	2032	34	fibrosis	fibrosis	NN
cord-006229-7yoilsho	2032	35	.	.	.
cord-006229-7yoilsho	2033	1	However	however	RB
cord-006229-7yoilsho	2033	2	,	,	,
cord-006229-7yoilsho	2033	3	their	-PRON-	PRP$
cord-006229-7yoilsho	2033	4	specific	specific	JJ
cord-006229-7yoilsho	2033	5	function	function	NN
cord-006229-7yoilsho	2033	6	in	in	IN
cord-006229-7yoilsho	2033	7	cardiac	cardiac	JJ
cord-006229-7yoilsho	2033	8	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	2033	9	(	(	-LRB-
cord-006229-7yoilsho	2033	10	CF	CF	NNP
cord-006229-7yoilsho	2033	11	)	)	-RRB-
cord-006229-7yoilsho	2033	12	remains	remain	VBZ
cord-006229-7yoilsho	2033	13	unclear	unclear	JJ
cord-006229-7yoilsho	2033	14	.	.	.
cord-006229-7yoilsho	2034	1	Remodelling	remodelling	NN
cord-006229-7yoilsho	2034	2	of	of	IN
cord-006229-7yoilsho	2034	3	the	the	DT
cord-006229-7yoilsho	2034	4	diseased	diseased	JJ
cord-006229-7yoilsho	2034	5	heart	heart	NN
cord-006229-7yoilsho	2034	6	results	result	NNS
cord-006229-7yoilsho	2034	7	in	in	IN
cord-006229-7yoilsho	2034	8	the	the	DT
cord-006229-7yoilsho	2034	9	transition	transition	NN
cord-006229-7yoilsho	2034	10	of	of	IN
cord-006229-7yoilsho	2034	11	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	2034	12	to	to	IN
cord-006229-7yoilsho	2034	13	a	a	DT
cord-006229-7yoilsho	2034	14	myofibroblast	myofibroblast	JJ
cord-006229-7yoilsho	2034	15	phenotype	phenotype	NN
cord-006229-7yoilsho	2034	16	exemplified	exemplify	VBN
cord-006229-7yoilsho	2034	17	by	by	IN
cord-006229-7yoilsho	2034	18	an	an	DT
cord-006229-7yoilsho	2034	19	increased	increase	VBN
cord-006229-7yoilsho	2034	20	proliferation	proliferation	NN
cord-006229-7yoilsho	2034	21	,	,	,
cord-006229-7yoilsho	2034	22	migration	migration	NN
cord-006229-7yoilsho	2034	23	rate	rate	NN
cord-006229-7yoilsho	2034	24	and	and	CC
cord-006229-7yoilsho	2034	25	synthesis	synthesis	NN
cord-006229-7yoilsho	2034	26	of	of	IN
cord-006229-7yoilsho	2034	27	extracellular	extracellular	JJ
cord-006229-7yoilsho	2034	28	matrix	matrix	NN
cord-006229-7yoilsho	2034	29	(	(	-LRB-
cord-006229-7yoilsho	2034	30	ECM	ECM	NNP
cord-006229-7yoilsho	2034	31	)	)	-RRB-
cord-006229-7yoilsho	2034	32	proteins	protein	NNS
cord-006229-7yoilsho	2034	33	.	.	.
cord-006229-7yoilsho	2035	1	Therefore	therefore	RB
cord-006229-7yoilsho	2035	2	,	,	,
cord-006229-7yoilsho	2035	3	we	-PRON-	PRP
cord-006229-7yoilsho	2035	4	sought	seek	VBD
cord-006229-7yoilsho	2035	5	to	to	TO
cord-006229-7yoilsho	2035	6	investigate	investigate	VB
cord-006229-7yoilsho	2035	7	whether	whether	IN
cord-006229-7yoilsho	2035	8	ROCK	rock	NN
cord-006229-7yoilsho	2035	9	protein	protein	NN
cord-006229-7yoilsho	2035	10	signalling	signal	VBG
cord-006229-7yoilsho	2035	11	intermediates	intermediate	NNS
cord-006229-7yoilsho	2035	12	have	have	VBP
cord-006229-7yoilsho	2035	13	an	an	DT
cord-006229-7yoilsho	2035	14	impact	impact	NN
cord-006229-7yoilsho	2035	15	on	on	IN
cord-006229-7yoilsho	2035	16	cellular	cellular	JJ
cord-006229-7yoilsho	2035	17	characteristics	characteristic	NNS
cord-006229-7yoilsho	2035	18	,	,	,
cord-006229-7yoilsho	2035	19	intracellular	intracellular	JJ
cord-006229-7yoilsho	2035	20	protein	protein	NN
cord-006229-7yoilsho	2035	21	expression	expression	NN
cord-006229-7yoilsho	2035	22	and	and	CC
cord-006229-7yoilsho	2035	23	mechanical	mechanical	JJ
cord-006229-7yoilsho	2035	24	properties	property	NNS
cord-006229-7yoilsho	2035	25	in	in	IN
cord-006229-7yoilsho	2035	26	CF	cf	NN
cord-006229-7yoilsho	2035	27	and	and	CC
cord-006229-7yoilsho	2035	28	engineered	engineer	VBN
cord-006229-7yoilsho	2035	29	tissues	tissue	NNS
cord-006229-7yoilsho	2035	30	.	.	.
cord-006229-7yoilsho	2036	1	Methods	method	NNS
cord-006229-7yoilsho	2036	2	:	:	:
cord-006229-7yoilsho	2037	1	Neonatal	neonatal	JJ
cord-006229-7yoilsho	2037	2	cardiac	cardiac	JJ
cord-006229-7yoilsho	2037	3	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	2037	4	were	be	VBD
cord-006229-7yoilsho	2037	5	isolated	isolate	VBN
cord-006229-7yoilsho	2037	6	from	from	IN
cord-006229-7yoilsho	2037	7	wild	wild	JJ
cord-006229-7yoilsho	2037	8	type	type	NN
cord-006229-7yoilsho	2037	9	rats	rat	NNS
cord-006229-7yoilsho	2037	10	and	and	CC
cord-006229-7yoilsho	2037	11	downregulation	downregulation	NN
cord-006229-7yoilsho	2037	12	of	of	IN
cord-006229-7yoilsho	2037	13	ROCK1	rock1	NN
cord-006229-7yoilsho	2037	14	and	and	CC
cord-006229-7yoilsho	2037	15	ROCK2	rock2	NN
cord-006229-7yoilsho	2037	16	by	by	IN
cord-006229-7yoilsho	2037	17	75	75	CD
cord-006229-7yoilsho	2037	18	%	%	NN
cord-006229-7yoilsho	2037	19	was	be	VBD
cord-006229-7yoilsho	2037	20	achieved	achieve	VBN
cord-006229-7yoilsho	2037	21	by	by	IN
cord-006229-7yoilsho	2037	22	lentiviral	lentiviral	JJ
cord-006229-7yoilsho	2037	23	transduction	transduction	NN
cord-006229-7yoilsho	2037	24	or	or	CC
cord-006229-7yoilsho	2037	25	transfection	transfection	NN
cord-006229-7yoilsho	2037	26	.	.	.
cord-006229-7yoilsho	2038	1	Wild	wild	JJ
cord-006229-7yoilsho	2038	2	type	type	NN
cord-006229-7yoilsho	2038	3	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	2038	4	were	be	VBD
cord-006229-7yoilsho	2038	5	treated	treat	VBN
cord-006229-7yoilsho	2038	6	with	with	IN
cord-006229-7yoilsho	2038	7	10	10	CD
cord-006229-7yoilsho	2038	8	μM	μM	NNP
cord-006229-7yoilsho	2038	9	Fasudil	Fasudil	NNP
cord-006229-7yoilsho	2038	10	or	or	CC
cord-006229-7yoilsho	2038	11	3	3	CD
cord-006229-7yoilsho	2038	12	µM	µm	VBP
cord-006229-7yoilsho	2038	13	H1152p	h1152p	RB
cord-006229-7yoilsho	2038	14	for	for	IN
cord-006229-7yoilsho	2038	15	general	general	JJ
cord-006229-7yoilsho	2038	16	ROCK	ROCK	NNP
cord-006229-7yoilsho	2038	17	inhibition	inhibition	NN
cord-006229-7yoilsho	2038	18	and	and	CC
cord-006229-7yoilsho	2039	1	3	3	LS
cord-006229-7yoilsho	2039	2	µM	µm	XX
cord-006229-7yoilsho	2040	1	SLx-2119	slx-2119	VB
cord-006229-7yoilsho	2040	2	for	for	IN
cord-006229-7yoilsho	2040	3	inhibition	inhibition	NN
cord-006229-7yoilsho	2040	4	of	of	IN
cord-006229-7yoilsho	2040	5	ROCK2	ROCK2	''
cord-006229-7yoilsho	2040	6	.	.	.
cord-006229-7yoilsho	2041	1	Protein	protein	NN
cord-006229-7yoilsho	2041	2	expression	expression	NN
cord-006229-7yoilsho	2041	3	and	and	CC
cord-006229-7yoilsho	2041	4	modification	modification	NN
cord-006229-7yoilsho	2041	5	was	be	VBD
cord-006229-7yoilsho	2041	6	determined	determine	VBN
cord-006229-7yoilsho	2041	7	by	by	IN
cord-006229-7yoilsho	2041	8	immunoblot	immunoblot	NNP
cord-006229-7yoilsho	2041	9	analysis	analysis	NNP
cord-006229-7yoilsho	2041	10	,	,	,
cord-006229-7yoilsho	2041	11	gene	gene	NN
cord-006229-7yoilsho	2041	12	expression	expression	NN
cord-006229-7yoilsho	2041	13	by	by	IN
cord-006229-7yoilsho	2041	14	qPCR	qPCR	NNP
cord-006229-7yoilsho	2041	15	analysis	analysis	NNP
cord-006229-7yoilsho	2041	16	,	,	,
cord-006229-7yoilsho	2041	17	CF	CF	NNP
cord-006229-7yoilsho	2041	18	morphology	morphology	NN
cord-006229-7yoilsho	2041	19	and	and	CC
cord-006229-7yoilsho	2041	20	the	the	DT
cord-006229-7yoilsho	2041	21	localisation	localisation	NN
cord-006229-7yoilsho	2041	22	of	of	IN
cord-006229-7yoilsho	2041	23	cytoskeletal	cytoskeletal	JJ
cord-006229-7yoilsho	2041	24	proteins	protein	NNS
cord-006229-7yoilsho	2041	25	by	by	IN
cord-006229-7yoilsho	2041	26	immunofluorescence	immunofluorescence	NN
cord-006229-7yoilsho	2041	27	analysis	analysis	NN
cord-006229-7yoilsho	2041	28	,	,	,
cord-006229-7yoilsho	2041	29	cell	cell	NN
cord-006229-7yoilsho	2041	30	proliferation	proliferation	NN
cord-006229-7yoilsho	2041	31	by	by	IN
cord-006229-7yoilsho	2041	32	automated	automate	VBN
cord-006229-7yoilsho	2041	33	nuclei	nucleus	NNS
cord-006229-7yoilsho	2041	34	counting	count	VBG
cord-006229-7yoilsho	2041	35	,	,	,
cord-006229-7yoilsho	2041	36	cell	cell	NN
cord-006229-7yoilsho	2041	37	migration	migration	NN
cord-006229-7yoilsho	2041	38	on	on	IN
cord-006229-7yoilsho	2041	39	a	a	DT
cord-006229-7yoilsho	2041	40	planar	planar	JJ
cord-006229-7yoilsho	2041	41	surface	surface	NN
cord-006229-7yoilsho	2041	42	by	by	IN
cord-006229-7yoilsho	2041	43	life	life	NN
cord-006229-7yoilsho	2041	44	cell	cell	NN
cord-006229-7yoilsho	2041	45	imaging	imaging	NN
cord-006229-7yoilsho	2041	46	,	,	,
cord-006229-7yoilsho	2041	47	and	and	CC
cord-006229-7yoilsho	2041	48	rigidity	rigidity	NN
cord-006229-7yoilsho	2041	49	of	of	IN
cord-006229-7yoilsho	2041	50	engineered	engineer	VBN
cord-006229-7yoilsho	2041	51	tissues	tissue	NNS
cord-006229-7yoilsho	2041	52	by	by	IN
cord-006229-7yoilsho	2041	53	rheological	rheological	JJ
cord-006229-7yoilsho	2041	54	measurement	measurement	NN
cord-006229-7yoilsho	2041	55	.	.	.
cord-006229-7yoilsho	2042	1	Results	result	NNS
cord-006229-7yoilsho	2042	2	:	:	:
cord-006229-7yoilsho	2043	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	2043	2	results	result	NNS
cord-006229-7yoilsho	2043	3	show	show	VBP
cord-006229-7yoilsho	2043	4	that	that	IN
cord-006229-7yoilsho	2043	5	both	both	CC
cord-006229-7yoilsho	2043	6	ROCK1	rock1	XX
cord-006229-7yoilsho	2043	7	and	and	CC
cord-006229-7yoilsho	2043	8	ROCK2	ROCK2	HYPH
cord-006229-7yoilsho	2043	9	influence	influence	NN
cord-006229-7yoilsho	2043	10	CF	cf	NN
cord-006229-7yoilsho	2043	11	morphology	morphology	NN
cord-006229-7yoilsho	2043	12	,	,	,
cord-006229-7yoilsho	2043	13	gene	gene	NN
cord-006229-7yoilsho	2043	14	expression	expression	NN
cord-006229-7yoilsho	2043	15	,	,	,
cord-006229-7yoilsho	2043	16	proliferation	proliferation	NN
cord-006229-7yoilsho	2043	17	and	and	CC
cord-006229-7yoilsho	2043	18	migration	migration	NN
cord-006229-7yoilsho	2043	19	.	.	.
cord-006229-7yoilsho	2044	1	The	the	DT
cord-006229-7yoilsho	2044	2	knockdown	knockdown	NN
cord-006229-7yoilsho	2044	3	and	and	CC
cord-006229-7yoilsho	2044	4	inhibition	inhibition	NN
cord-006229-7yoilsho	2044	5	of	of	IN
cord-006229-7yoilsho	2044	6	ROCKs	rock	NNS
cord-006229-7yoilsho	2044	7	was	be	VBD
cord-006229-7yoilsho	2044	8	associated	associate	VBN
cord-006229-7yoilsho	2044	9	with	with	IN
cord-006229-7yoilsho	2044	10	changes	change	NNS
cord-006229-7yoilsho	2044	11	in	in	IN
cord-006229-7yoilsho	2044	12	CF	CF	NNP
cord-006229-7yoilsho	2044	13	morphology	morphology	NN
cord-006229-7yoilsho	2044	14	accompanied	accompany	VBN
cord-006229-7yoilsho	2044	15	by	by	IN
cord-006229-7yoilsho	2044	16	a	a	DT
cord-006229-7yoilsho	2044	17	disorganization	disorganization	NN
cord-006229-7yoilsho	2044	18	of	of	IN
cord-006229-7yoilsho	2044	19	higher	high	JJR
cord-006229-7yoilsho	2044	20	-	-	HYPH
cord-006229-7yoilsho	2044	21	order	order	NN
cord-006229-7yoilsho	2044	22	actin	actin	NN
cord-006229-7yoilsho	2044	23	structures	structure	NNS
cord-006229-7yoilsho	2044	24	including	include	VBG
cord-006229-7yoilsho	2044	25	stress	stress	NN
cord-006229-7yoilsho	2044	26	fibers	fiber	NNS
cord-006229-7yoilsho	2044	27	and	and	CC
cord-006229-7yoilsho	2044	28	geodesic	geodesic	NN
cord-006229-7yoilsho	2044	29	domes	dome	NNS
cord-006229-7yoilsho	2044	30	.	.	.
cord-006229-7yoilsho	2045	1	Moreover	moreover	RB
cord-006229-7yoilsho	2045	2	,	,	,
cord-006229-7yoilsho	2045	3	the	the	DT
cord-006229-7yoilsho	2045	4	knockdown	knockdown	NN
cord-006229-7yoilsho	2045	5	of	of	IN
cord-006229-7yoilsho	2045	6	ROCK1	rock1	NN
cord-006229-7yoilsho	2045	7	and	and	CC
cord-006229-7yoilsho	2045	8	ROCK2	rock2	NN
cord-006229-7yoilsho	2045	9	in	in	IN
cord-006229-7yoilsho	2045	10	CF	CF	NNP
cord-006229-7yoilsho	2045	11	increased	increase	VBN
cord-006229-7yoilsho	2045	12	adhesion	adhesion	NN
cord-006229-7yoilsho	2045	13	velocity	velocity	NN
cord-006229-7yoilsho	2045	14	,	,	,
cord-006229-7yoilsho	2045	15	whereas	whereas	IN
cord-006229-7yoilsho	2045	16	proliferation	proliferation	NN
cord-006229-7yoilsho	2045	17	was	be	VBD
cord-006229-7yoilsho	2045	18	attenuated	attenuate	VBN
cord-006229-7yoilsho	2045	19	.	.	.
cord-006229-7yoilsho	2046	1	Interestingly	interestingly	RB
cord-006229-7yoilsho	2046	2	,	,	,
cord-006229-7yoilsho	2046	3	downregulation	downregulation	NN
cord-006229-7yoilsho	2046	4	of	of	IN
cord-006229-7yoilsho	2046	5	ROCK2	rock2	NN
cord-006229-7yoilsho	2046	6	,	,	,
cord-006229-7yoilsho	2046	7	but	but	CC
cord-006229-7yoilsho	2046	8	not	not	RB
cord-006229-7yoilsho	2046	9	of	of	IN
cord-006229-7yoilsho	2046	10	ROCK1	rock1	NN
cord-006229-7yoilsho	2046	11	led	lead	VBD
cord-006229-7yoilsho	2046	12	to	to	IN
cord-006229-7yoilsho	2046	13	a	a	DT
cord-006229-7yoilsho	2046	14	significantly	significantly	RB
cord-006229-7yoilsho	2046	15	decreased	decrease	VBN
cord-006229-7yoilsho	2046	16	migration	migration	NN
cord-006229-7yoilsho	2046	17	velocity	velocity	NN
cord-006229-7yoilsho	2046	18	and	and	CC
cord-006229-7yoilsho	2046	19	distance	distance	NN
cord-006229-7yoilsho	2046	20	suggesting	suggest	VBG
cord-006229-7yoilsho	2046	21	an	an	DT
cord-006229-7yoilsho	2046	22	isolated	isolated	JJ
cord-006229-7yoilsho	2046	23	principle	principle	JJ
cord-006229-7yoilsho	2046	24	role	role	NN
cord-006229-7yoilsho	2046	25	for	for	IN
cord-006229-7yoilsho	2046	26	ROCK2	rock2	NN
cord-006229-7yoilsho	2046	27	in	in	IN
cord-006229-7yoilsho	2046	28	cardiac	cardiac	JJ
cord-006229-7yoilsho	2046	29	fibroblast	fibroblast	NN
cord-006229-7yoilsho	2046	30	migratory	migratory	JJ
cord-006229-7yoilsho	2046	31	behavior	behavior	NN
cord-006229-7yoilsho	2046	32	.	.	.
cord-006229-7yoilsho	2047	1	Analysis	analysis	NN
cord-006229-7yoilsho	2047	2	of	of	IN
cord-006229-7yoilsho	2047	3	a	a	DT
cord-006229-7yoilsho	2047	4	three	three	CD
cord-006229-7yoilsho	2047	5	dimensional	dimensional	JJ
cord-006229-7yoilsho	2047	6	engineered	engineer	VBN
cord-006229-7yoilsho	2047	7	tissue	tissue	NN
cord-006229-7yoilsho	2047	8	model	model	NN
cord-006229-7yoilsho	2047	9	composed	compose	VBN
cord-006229-7yoilsho	2047	10	of	of	IN
cord-006229-7yoilsho	2047	11	cardiac	cardiac	JJ
cord-006229-7yoilsho	2047	12	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	2047	13	(	(	-LRB-
cord-006229-7yoilsho	2047	14	engineered	engineer	VBN
cord-006229-7yoilsho	2047	15	connective	connective	JJ
cord-006229-7yoilsho	2047	16	tissue	tissue	NN
cord-006229-7yoilsho	2047	17	,	,	,
cord-006229-7yoilsho	2047	18	ECT	ECT	NNP
cord-006229-7yoilsho	2047	19	)	)	-RRB-
cord-006229-7yoilsho	2047	20	suggested	suggest	VBD
cord-006229-7yoilsho	2047	21	that	that	IN
cord-006229-7yoilsho	2047	22	ROCKs	rock	NNS
cord-006229-7yoilsho	2047	23	are	be	VBP
cord-006229-7yoilsho	2047	24	involved	involve	VBN
cord-006229-7yoilsho	2047	25	in	in	IN
cord-006229-7yoilsho	2047	26	the	the	DT
cord-006229-7yoilsho	2047	27	regulation	regulation	NN
cord-006229-7yoilsho	2047	28	and	and	CC
cord-006229-7yoilsho	2047	29	turnover	turnover	NN
cord-006229-7yoilsho	2047	30	of	of	IN
cord-006229-7yoilsho	2047	31	the	the	DT
cord-006229-7yoilsho	2047	32	extracellular	extracellular	JJ
cord-006229-7yoilsho	2047	33	matrix	matrix	NN
cord-006229-7yoilsho	2047	34	(	(	-LRB-
cord-006229-7yoilsho	2047	35	ECM	ECM	NNP
cord-006229-7yoilsho	2047	36	)	)	-RRB-
cord-006229-7yoilsho	2047	37	and	and	CC
cord-006229-7yoilsho	2047	38	thus	thus	RB
cord-006229-7yoilsho	2047	39	influence	influence	VB
cord-006229-7yoilsho	2047	40	viscoelastic	viscoelastic	JJ
cord-006229-7yoilsho	2047	41	properties	property	NNS
cord-006229-7yoilsho	2047	42	of	of	IN
cord-006229-7yoilsho	2047	43	engineered	engineer	VBN
cord-006229-7yoilsho	2047	44	tissues	tissue	NNS
cord-006229-7yoilsho	2047	45	.	.	.
cord-006229-7yoilsho	2048	1	Destructive	destructive	JJ
cord-006229-7yoilsho	2048	2	tensile	tensile	JJ
cord-006229-7yoilsho	2048	3	strength	strength	NN
cord-006229-7yoilsho	2048	4	measurement	measurement	NN
cord-006229-7yoilsho	2048	5	in	in	IN
cord-006229-7yoilsho	2048	6	ECT	ECT	NNP
cord-006229-7yoilsho	2048	7	treated	treat	VBN
cord-006229-7yoilsho	2048	8	with	with	IN
cord-006229-7yoilsho	2048	9	ROCK	ROCK	NNP
cord-006229-7yoilsho	2048	10	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	2049	1	showed	show	VBD
cord-006229-7yoilsho	2049	2	that	that	IN
cord-006229-7yoilsho	2049	3	rigidity	rigidity	NN
cord-006229-7yoilsho	2049	4	was	be	VBD
cord-006229-7yoilsho	2049	5	significantly	significantly	RB
cord-006229-7yoilsho	2049	6	reduced	reduce	VBN
cord-006229-7yoilsho	2049	7	when	when	WRB
cord-006229-7yoilsho	2049	8	compared	compare	VBN
cord-006229-7yoilsho	2049	9	to	to	TO
cord-006229-7yoilsho	2049	10	control	control	NN
cord-006229-7yoilsho	2049	11	tissues	tissue	NNS
cord-006229-7yoilsho	2049	12	.	.	.
cord-006229-7yoilsho	2050	1	RNA	rna	NN
cord-006229-7yoilsho	2050	2	sequencing	sequencing	NN
cord-006229-7yoilsho	2050	3	of	of	IN
cord-006229-7yoilsho	2050	4	ECT	ECT	NNP
cord-006229-7yoilsho	2050	5	treated	treat	VBN
cord-006229-7yoilsho	2050	6	with	with	IN
cord-006229-7yoilsho	2050	7	the	the	DT
cord-006229-7yoilsho	2050	8	ROCK	ROCK	NNP
cord-006229-7yoilsho	2050	9	inhibitor	inhibitor	NN
cord-006229-7yoilsho	2050	10	H1152p	H1152p	NNS
cord-006229-7yoilsho	2050	11	and	and	CC
cord-006229-7yoilsho	2050	12	qPCR	qPCR	NNP
cord-006229-7yoilsho	2050	13	analysis	analysis	NN
cord-006229-7yoilsho	2050	14	of	of	IN
cord-006229-7yoilsho	2050	15	CF	CF	NNP
cord-006229-7yoilsho	2050	16	with	with	IN
cord-006229-7yoilsho	2050	17	a	a	DT
cord-006229-7yoilsho	2050	18	downregulation	downregulation	NN
cord-006229-7yoilsho	2050	19	of	of	IN
cord-006229-7yoilsho	2050	20	ROCK1	rock1	NN
cord-006229-7yoilsho	2050	21	and	and	CC
cord-006229-7yoilsho	2050	22	ROCK2	rock2	NN
cord-006229-7yoilsho	2051	1	showed	show	VBD
cord-006229-7yoilsho	2051	2	that	that	IN
cord-006229-7yoilsho	2051	3	both	both	DT
cord-006229-7yoilsho	2051	4	ROCKs	rock	NNS
cord-006229-7yoilsho	2051	5	are	be	VBP
cord-006229-7yoilsho	2051	6	involved	involve	VBN
cord-006229-7yoilsho	2051	7	in	in	IN
cord-006229-7yoilsho	2051	8	the	the	DT
cord-006229-7yoilsho	2051	9	regulation	regulation	NN
cord-006229-7yoilsho	2051	10	of	of	IN
cord-006229-7yoilsho	2051	11	ECM	ECM	NNP
cord-006229-7yoilsho	2051	12	proteins	protein	NNS
cord-006229-7yoilsho	2051	13	,	,	,
cord-006229-7yoilsho	2051	14	such	such	JJ
cord-006229-7yoilsho	2051	15	as	as	IN
cord-006229-7yoilsho	2051	16	collagens	collagen	NNS
cord-006229-7yoilsho	2051	17	4a2	4a2	CD
cord-006229-7yoilsho	2051	18	,	,	,
cord-006229-7yoilsho	2051	19	6a	6a	CD
cord-006229-7yoilsho	2051	20	,	,	,
cord-006229-7yoilsho	2051	21	and	and	CC
cord-006229-7yoilsho	2051	22	8a1	8a1	NNP
cord-006229-7yoilsho	2051	23	,	,	,
cord-006229-7yoilsho	2051	24	biglycan	biglycan	NNP
cord-006229-7yoilsho	2051	25	,	,	,
cord-006229-7yoilsho	2051	26	decorin	decorin	NNP
cord-006229-7yoilsho	2051	27	,	,	,
cord-006229-7yoilsho	2051	28	elastin	elastin	NN
cord-006229-7yoilsho	2051	29	and	and	CC
cord-006229-7yoilsho	2051	30	its	-PRON-	PRP$
cord-006229-7yoilsho	2051	31	respective	respective	JJ
cord-006229-7yoilsho	2051	32	degrading	degrade	VBG
cord-006229-7yoilsho	2051	33	enzyme	enzyme	NN
cord-006229-7yoilsho	2051	34	MMP12	mmp12	NN
cord-006229-7yoilsho	2051	35	.	.	.
cord-006229-7yoilsho	2052	1	Conclusion	conclusion	NN
cord-006229-7yoilsho	2052	2	:	:	:
cord-006229-7yoilsho	2053	1	This	this	DT
cord-006229-7yoilsho	2053	2	study	study	NN
cord-006229-7yoilsho	2053	3	demonstrates	demonstrate	VBZ
cord-006229-7yoilsho	2053	4	that	that	IN
cord-006229-7yoilsho	2053	5	ROCK	ROCK	NNP
cord-006229-7yoilsho	2053	6	signalling	signalling	NN
cord-006229-7yoilsho	2053	7	controls	control	NNS
cord-006229-7yoilsho	2053	8	myofibroblast	myofibroblast	JJ
cord-006229-7yoilsho	2053	9	characteristics	characteristic	NNS
cord-006229-7yoilsho	2053	10	of	of	IN
cord-006229-7yoilsho	2053	11	CF	CF	NNP
cord-006229-7yoilsho	2053	12	via	via	IN
cord-006229-7yoilsho	2053	13	remodelling	remodelling	NN
cord-006229-7yoilsho	2053	14	of	of	IN
cord-006229-7yoilsho	2053	15	the	the	DT
cord-006229-7yoilsho	2053	16	cytoskeleton	cytoskeleton	NN
cord-006229-7yoilsho	2053	17	and	and	CC
cord-006229-7yoilsho	2053	18	the	the	DT
cord-006229-7yoilsho	2053	19	ECM	ECM	NNP
cord-006229-7yoilsho	2053	20	.	.	.
cord-006229-7yoilsho	2054	1	Background	background	NN
cord-006229-7yoilsho	2054	2	:	:	:
cord-006229-7yoilsho	2055	1	Regulation	regulation	NN
cord-006229-7yoilsho	2055	2	and	and	CC
cord-006229-7yoilsho	2055	3	fine	fine	RB
cord-006229-7yoilsho	2055	4	-	-	HYPH
cord-006229-7yoilsho	2055	5	tuning	tuning	NN
cord-006229-7yoilsho	2055	6	of	of	IN
cord-006229-7yoilsho	2055	7	gene	gene	NN
cord-006229-7yoilsho	2055	8	transcription	transcription	NN
cord-006229-7yoilsho	2055	9	in	in	IN
cord-006229-7yoilsho	2055	10	cardiomyocytes	cardiomyocyte	NNS
cord-006229-7yoilsho	2055	11	(	(	-LRB-
cord-006229-7yoilsho	2055	12	CMs	CMs	NNP
cord-006229-7yoilsho	2055	13	)	)	-RRB-
cord-006229-7yoilsho	2055	14	is	be	VBZ
cord-006229-7yoilsho	2055	15	a	a	DT
cord-006229-7yoilsho	2055	16	centerpiece	centerpiece	NN
cord-006229-7yoilsho	2055	17	of	of	IN
cord-006229-7yoilsho	2055	18	cardiac	cardiac	JJ
cord-006229-7yoilsho	2055	19	development	development	NN
cord-006229-7yoilsho	2055	20	,	,	,
cord-006229-7yoilsho	2055	21	function	function	NN
cord-006229-7yoilsho	2055	22	,	,	,
cord-006229-7yoilsho	2055	23	and	and	CC
cord-006229-7yoilsho	2055	24	disease	disease	NN
cord-006229-7yoilsho	2055	25	.	.	.
cord-006229-7yoilsho	2056	1	In	in	IN
cord-006229-7yoilsho	2056	2	order	order	NN
cord-006229-7yoilsho	2056	3	to	to	TO
cord-006229-7yoilsho	2056	4	obtain	obtain	VB
cord-006229-7yoilsho	2056	5	authentic	authentic	JJ
cord-006229-7yoilsho	2056	6	data	datum	NNS
cord-006229-7yoilsho	2056	7	,	,	,
cord-006229-7yoilsho	2056	8	cell	cell	NN
cord-006229-7yoilsho	2056	9	type	type	NN
cord-006229-7yoilsho	2056	10	-	-	HYPH
cord-006229-7yoilsho	2056	11	specific	specific	JJ
cord-006229-7yoilsho	2056	12	analyses	analysis	NNS
cord-006229-7yoilsho	2056	13	are	be	VBP
cord-006229-7yoilsho	2056	14	indispensable	indispensable	JJ
cord-006229-7yoilsho	2056	15	.	.	.
cord-006229-7yoilsho	2057	1	Recently	recently	RB
cord-006229-7yoilsho	2057	2	,	,	,
cord-006229-7yoilsho	2057	3	high	high	JJ
cord-006229-7yoilsho	2057	4	-	-	HYPH
cord-006229-7yoilsho	2057	5	purity	purity	NN
cord-006229-7yoilsho	2057	6	isolation	isolation	NN
cord-006229-7yoilsho	2057	7	protocols	protocol	NNS
cord-006229-7yoilsho	2057	8	for	for	IN
cord-006229-7yoilsho	2057	9	CM	cm	NN
cord-006229-7yoilsho	2057	10	nuclei	nucleus	NNS
cord-006229-7yoilsho	2057	11	were	be	VBD
cord-006229-7yoilsho	2057	12	established	establish	VBN
cord-006229-7yoilsho	2057	13	[	[	-LRB-
cord-006229-7yoilsho	2057	14	Bergmann	Bergmann	NNP
cord-006229-7yoilsho	2057	15	,	,	,
cord-006229-7yoilsho	2057	16	Exp	Exp	NNP
cord-006229-7yoilsho	2057	17	Cell	Cell	NNP
cord-006229-7yoilsho	2057	18	Res	Res	NNP
cord-006229-7yoilsho	2057	19	,	,	,
cord-006229-7yoilsho	2057	20	2011	2011	CD
cord-006229-7yoilsho	2057	21	]	]	-RRB-
cord-006229-7yoilsho	2057	22	and	and	CC
cord-006229-7yoilsho	2057	23	employed	employ	VBN
cord-006229-7yoilsho	2057	24	for	for	IN
cord-006229-7yoilsho	2057	25	detailed	detailed	JJ
cord-006229-7yoilsho	2057	26	genetic	genetic	JJ
cord-006229-7yoilsho	2057	27	and	and	CC
cord-006229-7yoilsho	2057	28	epigenetic	epigenetic	JJ
cord-006229-7yoilsho	2057	29	studies	study	NNS
cord-006229-7yoilsho	2057	30	on	on	IN
cord-006229-7yoilsho	2057	31	cardiac	cardiac	JJ
cord-006229-7yoilsho	2057	32	gene	gene	NN
cord-006229-7yoilsho	2057	33	transcription	transcription	NN
cord-006229-7yoilsho	2057	34	[	[	-LRB-
cord-006229-7yoilsho	2057	35	Gilsbach	Gilsbach	NNP
cord-006229-7yoilsho	2057	36	,	,	,
cord-006229-7yoilsho	2057	37	Nat	Nat	NNP
cord-006229-7yoilsho	2057	38	Commun	Commun	NNP
cord-006229-7yoilsho	2057	39	,	,	,
cord-006229-7yoilsho	2057	40	2014	2014	CD
cord-006229-7yoilsho	2057	41	]	]	-RRB-
cord-006229-7yoilsho	2057	42	.	.	.
cord-006229-7yoilsho	2058	1	However	however	RB
cord-006229-7yoilsho	2058	2	,	,	,
cord-006229-7yoilsho	2058	3	corresponding	correspond	VBG
cord-006229-7yoilsho	2058	4	protein	protein	NN
cord-006229-7yoilsho	2058	5	analyses	analysis	NNS
cord-006229-7yoilsho	2058	6	,	,	,
cord-006229-7yoilsho	2058	7	which	which	WDT
cord-006229-7yoilsho	2058	8	bridge	bridge	VBP
cord-006229-7yoilsho	2058	9	from	from	IN
cord-006229-7yoilsho	2058	10	transcriptional	transcriptional	JJ
cord-006229-7yoilsho	2058	11	control	control	NN
cord-006229-7yoilsho	2058	12	to	to	IN
cord-006229-7yoilsho	2058	13	CM	CM	NNP
cord-006229-7yoilsho	2058	14	function	function	NN
cord-006229-7yoilsho	2058	15	are	be	VBP
cord-006229-7yoilsho	2058	16	still	still	RB
cord-006229-7yoilsho	2058	17	lacking	lack	VBG
cord-006229-7yoilsho	2058	18	.	.	.
cord-006229-7yoilsho	2059	1	Therefore	therefore	RB
cord-006229-7yoilsho	2059	2	,	,	,
cord-006229-7yoilsho	2059	3	we	-PRON-	PRP
cord-006229-7yoilsho	2059	4	aimed	aim	VBD
cord-006229-7yoilsho	2059	5	to	to	TO
cord-006229-7yoilsho	2059	6	map	map	VB
cord-006229-7yoilsho	2059	7	the	the	DT
cord-006229-7yoilsho	2059	8	landscape	landscape	NN
cord-006229-7yoilsho	2059	9	of	of	IN
cord-006229-7yoilsho	2059	10	nuclear	nuclear	JJ
cord-006229-7yoilsho	2059	11	protein	protein	NN
cord-006229-7yoilsho	2059	12	expression	expression	NN
cord-006229-7yoilsho	2059	13	in	in	IN
cord-006229-7yoilsho	2059	14	newborn	newborn	JJ
cord-006229-7yoilsho	2059	15	and	and	CC
cord-006229-7yoilsho	2059	16	adult	adult	NN
cord-006229-7yoilsho	2059	17	mice	mouse	NNS
cord-006229-7yoilsho	2059	18	in	in	IN
cord-006229-7yoilsho	2059	19	order	order	NN
cord-006229-7yoilsho	2059	20	to	to	TO
cord-006229-7yoilsho	2059	21	complement	complement	VB
cord-006229-7yoilsho	2059	22	and	and	CC
cord-006229-7yoilsho	2059	23	extend	extend	VB
cord-006229-7yoilsho	2059	24	our	-PRON-	PRP$
cord-006229-7yoilsho	2059	25	epigenetic	epigenetic	JJ
cord-006229-7yoilsho	2059	26	studies	study	NNS
cord-006229-7yoilsho	2059	27	.	.	.
cord-006229-7yoilsho	2060	1	Methods	method	NNS
cord-006229-7yoilsho	2060	2	and	and	CC
cord-006229-7yoilsho	2060	3	Results	result	NNS
cord-006229-7yoilsho	2060	4	:	:	:
cord-006229-7yoilsho	2060	5	Cardiac	cardiac	JJ
cord-006229-7yoilsho	2060	6	nuclei	nucleus	NNS
cord-006229-7yoilsho	2060	7	were	be	VBD
cord-006229-7yoilsho	2060	8	isolated	isolate	VBN
cord-006229-7yoilsho	2060	9	from	from	IN
cord-006229-7yoilsho	2060	10	homogenized	homogenized	JJ
cord-006229-7yoilsho	2060	11	adult	adult	NN
cord-006229-7yoilsho	2060	12	and	and	CC
cord-006229-7yoilsho	2060	13	P1	P1	NNP
cord-006229-7yoilsho	2060	14	mouse	mouse	NN
cord-006229-7yoilsho	2060	15	frozen	frozen	JJ
cord-006229-7yoilsho	2060	16	hearts	heart	NNS
cord-006229-7yoilsho	2060	17	by	by	IN
cord-006229-7yoilsho	2060	18	sucrose	sucrose	NN
cord-006229-7yoilsho	2060	19	gradient	gradient	NN
cord-006229-7yoilsho	2060	20	centrifugation	centrifugation	NN
cord-006229-7yoilsho	2060	21	.	.	.
cord-006229-7yoilsho	2061	1	Magnetic	magnetic	JJ
cord-006229-7yoilsho	2061	2	-	-	HYPH
cord-006229-7yoilsho	2061	3	assisted	assisted	JJ
cord-006229-7yoilsho	2061	4	cell	cell	NN
cord-006229-7yoilsho	2061	5	sorting	sorting	NN
cord-006229-7yoilsho	2061	6	(	(	-LRB-
cord-006229-7yoilsho	2061	7	MACS	MACS	NNP
cord-006229-7yoilsho	2061	8	)	)	-RRB-
cord-006229-7yoilsho	2061	9	with	with	IN
cord-006229-7yoilsho	2061	10	PCM-1	PCM-1	NNP
cord-006229-7yoilsho	2061	11	as	as	IN
cord-006229-7yoilsho	2061	12	a	a	DT
cord-006229-7yoilsho	2061	13	nucleus	nucleus	RB
cord-006229-7yoilsho	2061	14	-	-	HYPH
cord-006229-7yoilsho	2061	15	specific	specific	JJ
cord-006229-7yoilsho	2061	16	marker	marker	NN
cord-006229-7yoilsho	2061	17	was	be	VBD
cord-006229-7yoilsho	2061	18	used	use	VBN
cord-006229-7yoilsho	2061	19	to	to	TO
cord-006229-7yoilsho	2061	20	enrich	enrich	VB
cord-006229-7yoilsho	2061	21	CM	cm	NN
cord-006229-7yoilsho	2061	22	nuclei	nucleus	NNS
cord-006229-7yoilsho	2061	23	to	to	IN
cord-006229-7yoilsho	2061	24	>	>	$
cord-006229-7yoilsho	2061	25	95	95	CD
cord-006229-7yoilsho	2061	26	%	%	NN
cord-006229-7yoilsho	2061	27	.	.	.
cord-006229-7yoilsho	2062	1	Proteins	protein	NNS
cord-006229-7yoilsho	2062	2	were	be	VBD
cord-006229-7yoilsho	2062	3	extracted	extract	VBN
cord-006229-7yoilsho	2062	4	from	from	IN
cord-006229-7yoilsho	2062	5	nuclear	nuclear	JJ
cord-006229-7yoilsho	2062	6	lysate	lysate	NN
cord-006229-7yoilsho	2062	7	with	with	IN
cord-006229-7yoilsho	2062	8	2	2	CD
cord-006229-7yoilsho	2062	9	%	%	NN
cord-006229-7yoilsho	2062	10	SDS	SDS	NNP
cord-006229-7yoilsho	2062	11	.	.	.
cord-006229-7yoilsho	2063	1	Quantitative	quantitative	JJ
cord-006229-7yoilsho	2063	2	protein	protein	NN
cord-006229-7yoilsho	2063	3	data	datum	NNS
cord-006229-7yoilsho	2063	4	were	be	VBD
cord-006229-7yoilsho	2063	5	obtained	obtain	VBN
cord-006229-7yoilsho	2063	6	from	from	IN
cord-006229-7yoilsho	2063	7	SILAC	silac	NN
cord-006229-7yoilsho	2063	8	-	-	HYPH
cord-006229-7yoilsho	2063	9	based	base	VBN
cord-006229-7yoilsho	2063	10	liquid	liquid	JJ
cord-006229-7yoilsho	2063	11	chromatographytandem	chromatographytandem	JJ
cord-006229-7yoilsho	2063	12	mass	mass	NN
cord-006229-7yoilsho	2063	13	spectrometry	spectrometry	NNP
cord-006229-7yoilsho	2063	14	(	(	-LRB-
cord-006229-7yoilsho	2063	15	LC	LC	NNP
cord-006229-7yoilsho	2063	16	-	-	HYPH
cord-006229-7yoilsho	2063	17	MS	MS	NNP
cord-006229-7yoilsho	2063	18	/	/	SYM
cord-006229-7yoilsho	2063	19	MS	MS	NNP
cord-006229-7yoilsho	2063	20	)	)	-RRB-
cord-006229-7yoilsho	2063	21	experiments	experiment	NNS
cord-006229-7yoilsho	2063	22	with	with	IN
cord-006229-7yoilsho	2063	23	an	an	DT
cord-006229-7yoilsho	2063	24	LTQ	LTQ	NNP
cord-006229-7yoilsho	2063	25	Orbitrap	Orbitrap	NNP
cord-006229-7yoilsho	2063	26	XL	XL	NNP
cord-006229-7yoilsho	2063	27	mass	mass	NN
cord-006229-7yoilsho	2063	28	spectrometer	spectrometer	NN
cord-006229-7yoilsho	2063	29	after	after	IN
cord-006229-7yoilsho	2063	30	in	in	IN
cord-006229-7yoilsho	2063	31	-	-	HYPH
cord-006229-7yoilsho	2063	32	gel	gel	NN
cord-006229-7yoilsho	2063	33	digestion	digestion	NN
cord-006229-7yoilsho	2063	34	with	with	IN
cord-006229-7yoilsho	2063	35	trypsin	trypsin	NN
cord-006229-7yoilsho	2063	36	.	.	.
cord-006229-7yoilsho	2064	1	Nuclear	nuclear	JJ
cord-006229-7yoilsho	2064	2	protein	protein	NN
cord-006229-7yoilsho	2064	3	extracts	extract	VBZ
cord-006229-7yoilsho	2064	4	from	from	IN
cord-006229-7yoilsho	2064	5	3	3	CD
cord-006229-7yoilsho	2064	6	murine	murine	JJ
cord-006229-7yoilsho	2064	7	cell	cell	NN
cord-006229-7yoilsho	2064	8	lines	line	NNS
cord-006229-7yoilsho	2064	9	served	serve	VBN
cord-006229-7yoilsho	2064	10	as	as	IN
cord-006229-7yoilsho	2064	11	SILAC	SILAC	NNP
cord-006229-7yoilsho	2064	12	(	(	-LRB-
cord-006229-7yoilsho	2064	13	Lys8	Lys8	NNP
cord-006229-7yoilsho	2064	14	/	/	SYM
cord-006229-7yoilsho	2064	15	Arg10)-labeled	arg10)-labele	VBN
cord-006229-7yoilsho	2064	16	internal	internal	JJ
cord-006229-7yoilsho	2064	17	standard	standard	NN
cord-006229-7yoilsho	2064	18	.	.	.
cord-006229-7yoilsho	2065	1	Finally	finally	RB
cord-006229-7yoilsho	2065	2	,	,	,
cord-006229-7yoilsho	2065	3	protein	protein	NN
cord-006229-7yoilsho	2065	4	data	datum	NNS
cord-006229-7yoilsho	2065	5	are	be	VBP
cord-006229-7yoilsho	2065	6	correlated	correlate	VBN
cord-006229-7yoilsho	2065	7	with	with	IN
cord-006229-7yoilsho	2065	8	corresponding	correspond	VBG
cord-006229-7yoilsho	2065	9	mRNA	mRNA	NNP
cord-006229-7yoilsho	2065	10	data	datum	NNS
cord-006229-7yoilsho	2065	11	obtained	obtain	VBN
cord-006229-7yoilsho	2065	12	by	by	IN
cord-006229-7yoilsho	2065	13	RNA	rna	NN
cord-006229-7yoilsho	2065	14	-	-	HYPH
cord-006229-7yoilsho	2065	15	sequencing	sequencing	NN
cord-006229-7yoilsho	2065	16	.	.	.
cord-006229-7yoilsho	2066	1	We	-PRON-	PRP
cord-006229-7yoilsho	2066	2	identified	identify	VBD
cord-006229-7yoilsho	2066	3	1041	1041	CD
cord-006229-7yoilsho	2066	4	proteins	protein	NNS
cord-006229-7yoilsho	2066	5	,	,	,
cord-006229-7yoilsho	2066	6	688	688	CD
cord-006229-7yoilsho	2066	7	of	of	IN
cord-006229-7yoilsho	2066	8	which	which	WDT
cord-006229-7yoilsho	2066	9	are	be	VBP
cord-006229-7yoilsho	2066	10	annotated	annotate	VBN
cord-006229-7yoilsho	2066	11	to	to	IN
cord-006229-7yoilsho	2066	12	the	the	DT
cord-006229-7yoilsho	2066	13	nucleus	nucleus	NN
cord-006229-7yoilsho	2066	14	.	.	.
cord-006229-7yoilsho	2067	1	21%/23	21%/23	CD
cord-006229-7yoilsho	2067	2	%	%	NN
cord-006229-7yoilsho	2067	3	(	(	-LRB-
cord-006229-7yoilsho	2067	4	Adult	Adult	NNP
cord-006229-7yoilsho	2067	5	/	/	SYM
cord-006229-7yoilsho	2067	6	P1	P1	NNP
cord-006229-7yoilsho	2067	7	)	)	-RRB-
cord-006229-7yoilsho	2067	8	of	of	IN
cord-006229-7yoilsho	2067	9	nuclear	nuclear	JJ
cord-006229-7yoilsho	2067	10	proteins	protein	NNS
cord-006229-7yoilsho	2067	11	are	be	VBP
cord-006229-7yoilsho	2067	12	annotated	annotate	VBN
cord-006229-7yoilsho	2067	13	as	as	IN
cord-006229-7yoilsho	2067	14	DNA	dna	NN
cord-006229-7yoilsho	2067	15	-	-	HYPH
cord-006229-7yoilsho	2067	16	binding	binding	NN
cord-006229-7yoilsho	2067	17	.	.	.
cord-006229-7yoilsho	2068	1	1.5%/1.4	1.5%/1.4	CD
cord-006229-7yoilsho	2068	2	%	%	NN
cord-006229-7yoilsho	2068	3	belong	belong	VBP
cord-006229-7yoilsho	2068	4	to	to	IN
cord-006229-7yoilsho	2068	5	transcription	transcription	NN
cord-006229-7yoilsho	2068	6	factor	factor	NN
cord-006229-7yoilsho	2068	7	complexes	complex	NNS
cord-006229-7yoilsho	2068	8	;	;	:
cord-006229-7yoilsho	2068	9	7.3%/7.5	7.3%/7.5	CD
cord-006229-7yoilsho	2068	10	%	%	NN
cord-006229-7yoilsho	2068	11	are	be	VBP
cord-006229-7yoilsho	2068	12	able	able	JJ
cord-006229-7yoilsho	2068	13	to	to	TO
cord-006229-7yoilsho	2068	14	bind	bind	VB
cord-006229-7yoilsho	2068	15	transcription	transcription	NN
cord-006229-7yoilsho	2068	16	factors	factor	NNS
cord-006229-7yoilsho	2068	17	.	.	.
cord-006229-7yoilsho	2069	1	7.9%/8.3	7.9%/8.3	CD
cord-006229-7yoilsho	2069	2	%	%	NN
cord-006229-7yoilsho	2069	3	have	have	VBP
cord-006229-7yoilsho	2069	4	chromatin	chromatin	NN
cord-006229-7yoilsho	2069	5	modification	modification	NN
cord-006229-7yoilsho	2069	6	functions	function	NNS
cord-006229-7yoilsho	2069	7	;	;	:
cord-006229-7yoilsho	2069	8	4.3%/4.4	4.3%/4.4	CD
cord-006229-7yoilsho	2069	9	%	%	NN
cord-006229-7yoilsho	2069	10	modify	modify	VBP
cord-006229-7yoilsho	2069	11	histones	histone	NNS
cord-006229-7yoilsho	2069	12	.	.	.
cord-006229-7yoilsho	2070	1	Nuclearenriched	Nuclearenriched	NNP
cord-006229-7yoilsho	2070	2	GO	GO	NNP
cord-006229-7yoilsho	2070	3	terms	term	NNS
cord-006229-7yoilsho	2070	4	include	include	VBP
cord-006229-7yoilsho	2070	5	mRNA	mrna	NN
cord-006229-7yoilsho	2070	6	processing	processing	NN
cord-006229-7yoilsho	2070	7	and	and	CC
cord-006229-7yoilsho	2070	8	transport	transport	NN
cord-006229-7yoilsho	2070	9	,	,	,
cord-006229-7yoilsho	2070	10	transcription	transcription	NN
cord-006229-7yoilsho	2070	11	,	,	,
cord-006229-7yoilsho	2070	12	nucleosome	nucleosome	NN
cord-006229-7yoilsho	2070	13	assembly	assembly	NN
cord-006229-7yoilsho	2070	14	and	and	CC
cord-006229-7yoilsho	2070	15	protein	protein	NN
cord-006229-7yoilsho	2070	16	degradation	degradation	NN
cord-006229-7yoilsho	2070	17	.	.	.
cord-006229-7yoilsho	2071	1	71	71	CD
cord-006229-7yoilsho	2071	2	%	%	NN
cord-006229-7yoilsho	2071	3	of	of	IN
cord-006229-7yoilsho	2071	4	proteins	protein	NNS
cord-006229-7yoilsho	2071	5	are	be	VBP
cord-006229-7yoilsho	2071	6	shared	share	VBN
cord-006229-7yoilsho	2071	7	between	between	IN
cord-006229-7yoilsho	2071	8	P1	p1	NN
cord-006229-7yoilsho	2071	9	and	and	CC
cord-006229-7yoilsho	2071	10	adult	adult	NN
cord-006229-7yoilsho	2071	11	nuclei	nucleus	NNS
cord-006229-7yoilsho	2071	12	.	.	.
cord-006229-7yoilsho	2072	1	142	142	CD
cord-006229-7yoilsho	2072	2	proteins	protein	NNS
cord-006229-7yoilsho	2072	3	are	be	VBP
cord-006229-7yoilsho	2072	4	exclusive	exclusive	JJ
cord-006229-7yoilsho	2072	5	to	to	IN
cord-006229-7yoilsho	2072	6	P1	P1	NNP
cord-006229-7yoilsho	2072	7	,	,	,
cord-006229-7yoilsho	2072	8	34	34	CD
cord-006229-7yoilsho	2072	9	are	be	VBP
cord-006229-7yoilsho	2072	10	only	only	RB
cord-006229-7yoilsho	2072	11	found	find	VBN
cord-006229-7yoilsho	2072	12	in	in	IN
cord-006229-7yoilsho	2072	13	adult	adult	NN
cord-006229-7yoilsho	2072	14	.	.	.
cord-006229-7yoilsho	2073	1	93	93	CD
cord-006229-7yoilsho	2073	2	proteins	protein	NNS
cord-006229-7yoilsho	2073	3	are	be	VBP
cord-006229-7yoilsho	2073	4	enriched	enrich	VBN
cord-006229-7yoilsho	2073	5	(	(	-LRB-
cord-006229-7yoilsho	2073	6	1.3-fold	1.3-fold	CD
cord-006229-7yoilsho	2073	7	increase	increase	NN
cord-006229-7yoilsho	2073	8	in	in	IN
cord-006229-7yoilsho	2073	9	abundance	abundance	NN
cord-006229-7yoilsho	2073	10	)	)	-RRB-
cord-006229-7yoilsho	2073	11	in	in	IN
cord-006229-7yoilsho	2073	12	P1	P1	NNP
cord-006229-7yoilsho	2073	13	hearts	heart	NNS
cord-006229-7yoilsho	2073	14	,	,	,
cord-006229-7yoilsho	2073	15	89	89	CD
cord-006229-7yoilsho	2073	16	proteins	protein	NNS
cord-006229-7yoilsho	2073	17	in	in	IN
cord-006229-7yoilsho	2073	18	adult	adult	NN
cord-006229-7yoilsho	2073	19	Proteins	protein	NNS
cord-006229-7yoilsho	2073	20	related	relate	VBN
cord-006229-7yoilsho	2073	21	to	to	IN
cord-006229-7yoilsho	2073	22	heart	heart	NN
cord-006229-7yoilsho	2073	23	development	development	NN
cord-006229-7yoilsho	2073	24	,	,	,
cord-006229-7yoilsho	2073	25	gene	gene	NN
cord-006229-7yoilsho	2073	26	silencing	silencing	NN
cord-006229-7yoilsho	2073	27	,	,	,
cord-006229-7yoilsho	2073	28	and	and	CC
cord-006229-7yoilsho	2073	29	DNA	dna	NN
cord-006229-7yoilsho	2073	30	replication	replication	NN
cord-006229-7yoilsho	2073	31	are	be	VBP
cord-006229-7yoilsho	2073	32	more	more	RBR
cord-006229-7yoilsho	2073	33	prominent	prominent	JJ
cord-006229-7yoilsho	2073	34	in	in	IN
cord-006229-7yoilsho	2073	35	or	or	CC
cord-006229-7yoilsho	2073	36	exclusive	exclusive	JJ
cord-006229-7yoilsho	2073	37	to	to	IN
cord-006229-7yoilsho	2073	38	newborn	newborn	JJ
cord-006229-7yoilsho	2073	39	mice	mouse	NNS
cord-006229-7yoilsho	2073	40	.	.	.
cord-006229-7yoilsho	2074	1	Adult	adult	NN
cord-006229-7yoilsho	2074	2	nuclei	nucleus	NNS
cord-006229-7yoilsho	2074	3	strongly	strongly	RB
cord-006229-7yoilsho	2074	4	express	express	VBP
cord-006229-7yoilsho	2074	5	proteins	protein	NNS
cord-006229-7yoilsho	2074	6	related	relate	VBN
cord-006229-7yoilsho	2074	7	to	to	IN
cord-006229-7yoilsho	2074	8	regulation	regulation	NN
cord-006229-7yoilsho	2074	9	of	of	IN
cord-006229-7yoilsho	2074	10	actin	actin	NN
cord-006229-7yoilsho	2074	11	fibers	fiber	NNS
cord-006229-7yoilsho	2074	12	and	and	CC
cord-006229-7yoilsho	2074	13	CM	cm	NN
cord-006229-7yoilsho	2074	14	function	function	NN
cord-006229-7yoilsho	2074	15	,	,	,
cord-006229-7yoilsho	2074	16	proteins	protein	NNS
cord-006229-7yoilsho	2074	17	involved	involve	VBN
cord-006229-7yoilsho	2074	18	in	in	IN
cord-006229-7yoilsho	2074	19	protein	protein	NN
cord-006229-7yoilsho	2074	20	degradation	degradation	NN
cord-006229-7yoilsho	2074	21	,	,	,
cord-006229-7yoilsho	2074	22	and	and	CC
cord-006229-7yoilsho	2074	23	chaperones	chaperone	NNS
cord-006229-7yoilsho	2074	24	.	.	.
cord-006229-7yoilsho	2075	1	Although	although	IN
cord-006229-7yoilsho	2075	2	high	high	JJ
cord-006229-7yoilsho	2075	3	mRNA	mRNA	NNP
cord-006229-7yoilsho	2075	4	expression	expression	NN
cord-006229-7yoilsho	2075	5	increases	increase	VBZ
cord-006229-7yoilsho	2075	6	the	the	DT
cord-006229-7yoilsho	2075	7	chance	chance	NN
cord-006229-7yoilsho	2075	8	of	of	IN
cord-006229-7yoilsho	2075	9	protein	protein	NN
cord-006229-7yoilsho	2075	10	identification	identification	NN
cord-006229-7yoilsho	2075	11	,	,	,
cord-006229-7yoilsho	2075	12	a	a	DT
cord-006229-7yoilsho	2075	13	significant	significant	JJ
cord-006229-7yoilsho	2075	14	correlation	correlation	NN
cord-006229-7yoilsho	2075	15	between	between	IN
cord-006229-7yoilsho	2075	16	mRNA	mrna	NN
cord-006229-7yoilsho	2075	17	and	and	CC
cord-006229-7yoilsho	2075	18	protein	protein	NN
cord-006229-7yoilsho	2075	19	level	level	NN
cord-006229-7yoilsho	2075	20	could	could	MD
cord-006229-7yoilsho	2075	21	not	not	RB
cord-006229-7yoilsho	2075	22	be	be	VB
cord-006229-7yoilsho	2075	23	observed	observe	VBN
cord-006229-7yoilsho	2075	24	on	on	IN
cord-006229-7yoilsho	2075	25	a	a	DT
cord-006229-7yoilsho	2075	26	genome	genome	NN
cord-006229-7yoilsho	2075	27	-	-	HYPH
cord-006229-7yoilsho	2075	28	wide	wide	JJ
cord-006229-7yoilsho	2075	29	scale	scale	NN
cord-006229-7yoilsho	2075	30	.	.	.
cord-006229-7yoilsho	2076	1	Conclusions	conclusion	NNS
cord-006229-7yoilsho	2076	2	:	:	:
cord-006229-7yoilsho	2077	1	We	-PRON-	PRP
cord-006229-7yoilsho	2077	2	present	present	VBP
cord-006229-7yoilsho	2077	3	a	a	DT
cord-006229-7yoilsho	2077	4	comprehensive	comprehensive	JJ
cord-006229-7yoilsho	2077	5	and	and	CC
cord-006229-7yoilsho	2077	6	specific	specific	JJ
cord-006229-7yoilsho	2077	7	protein	protein	NN
cord-006229-7yoilsho	2077	8	landscape	landscape	NN
cord-006229-7yoilsho	2077	9	of	of	IN
cord-006229-7yoilsho	2077	10	newborn	newborn	JJ
cord-006229-7yoilsho	2077	11	and	and	CC
cord-006229-7yoilsho	2077	12	adult	adult	NN
cord-006229-7yoilsho	2077	13	CM	cm	NN
cord-006229-7yoilsho	2077	14	nuclei	nucleus	NNS
cord-006229-7yoilsho	2077	15	.	.	.
cord-006229-7yoilsho	2078	1	Young	young	JJ
cord-006229-7yoilsho	2078	2	CM	cm	NN
cord-006229-7yoilsho	2078	3	nuclei	nucleus	NNS
cord-006229-7yoilsho	2078	4	appear	appear	VBP
cord-006229-7yoilsho	2078	5	as	as	IN
cord-006229-7yoilsho	2078	6	a	a	DT
cord-006229-7yoilsho	2078	7	developing	develop	VBG
cord-006229-7yoilsho	2078	8	tissue	tissue	NN
cord-006229-7yoilsho	2078	9	,	,	,
cord-006229-7yoilsho	2078	10	show	show	VB
cord-006229-7yoilsho	2078	11	the	the	DT
cord-006229-7yoilsho	2078	12	ability	ability	NN
cord-006229-7yoilsho	2078	13	for	for	IN
cord-006229-7yoilsho	2078	14	proliferation	proliferation	NN
cord-006229-7yoilsho	2078	15	,	,	,
cord-006229-7yoilsho	2078	16	and	and	CC
cord-006229-7yoilsho	2078	17	indicate	indicate	VBP
cord-006229-7yoilsho	2078	18	ongoing	ongoing	JJ
cord-006229-7yoilsho	2078	19	alterations	alteration	NNS
cord-006229-7yoilsho	2078	20	in	in	IN
cord-006229-7yoilsho	2078	21	gene	gene	NN
cord-006229-7yoilsho	2078	22	expression	expression	NN
cord-006229-7yoilsho	2078	23	.	.	.
cord-006229-7yoilsho	2079	1	Adult	adult	NN
cord-006229-7yoilsho	2079	2	CM	cm	NN
cord-006229-7yoilsho	2079	3	nuclei	nucleus	NNS
cord-006229-7yoilsho	2079	4	prominently	prominently	RB
cord-006229-7yoilsho	2079	5	display	display	VBP
cord-006229-7yoilsho	2079	6	a	a	DT
cord-006229-7yoilsho	2079	7	focus	focus	NN
cord-006229-7yoilsho	2079	8	on	on	IN
cord-006229-7yoilsho	2079	9	regulation	regulation	NN
cord-006229-7yoilsho	2079	10	of	of	IN
cord-006229-7yoilsho	2079	11	contractile	contractile	JJ
cord-006229-7yoilsho	2079	12	fibers	fiber	NNS
cord-006229-7yoilsho	2079	13	and	and	CC
cord-006229-7yoilsho	2079	14	CM	cm	NN
cord-006229-7yoilsho	2079	15	function	function	NN
cord-006229-7yoilsho	2079	16	,	,	,
cord-006229-7yoilsho	2079	17	as	as	RB
cord-006229-7yoilsho	2079	18	well	well	RB
cord-006229-7yoilsho	2079	19	as	as	IN
cord-006229-7yoilsho	2079	20	chaperones	chaperone	NNS
cord-006229-7yoilsho	2079	21	and	and	CC
cord-006229-7yoilsho	2079	22	proteasomal	proteasomal	JJ
cord-006229-7yoilsho	2079	23	proteins	protein	NNS
cord-006229-7yoilsho	2079	24	indicative	indicative	JJ
cord-006229-7yoilsho	2079	25	of	of	IN
cord-006229-7yoilsho	2079	26	its	-PRON-	PRP$
cord-006229-7yoilsho	2079	27	arduous	arduous	JJ
cord-006229-7yoilsho	2079	28	function	function	NN
cord-006229-7yoilsho	2079	29	.	.	.
cord-006229-7yoilsho	2080	1	Background	background	NN
cord-006229-7yoilsho	2080	2	:	:	:
cord-006229-7yoilsho	2081	1	Fibrosis	fibrosis	NN
cord-006229-7yoilsho	2081	2	is	be	VBZ
cord-006229-7yoilsho	2081	3	a	a	DT
cord-006229-7yoilsho	2081	4	hallmark	hallmark	NN
cord-006229-7yoilsho	2081	5	of	of	IN
cord-006229-7yoilsho	2081	6	many	many	JJ
cord-006229-7yoilsho	2081	7	myocardial	myocardial	JJ
cord-006229-7yoilsho	2081	8	pathologies	pathology	NNS
cord-006229-7yoilsho	2081	9	and	and	CC
cord-006229-7yoilsho	2081	10	contributes	contribute	VBZ
cord-006229-7yoilsho	2081	11	to	to	IN
cord-006229-7yoilsho	2081	12	distorted	distorted	JJ
cord-006229-7yoilsho	2081	13	organ	organ	NN
cord-006229-7yoilsho	2081	14	architecture	architecture	NN
cord-006229-7yoilsho	2081	15	and	and	CC
cord-006229-7yoilsho	2081	16	function	function	NN
cord-006229-7yoilsho	2081	17	.	.	.
cord-006229-7yoilsho	2082	1	Recent	recent	JJ
cord-006229-7yoilsho	2082	2	studies	study	NNS
cord-006229-7yoilsho	2082	3	have	have	VBP
cord-006229-7yoilsho	2082	4	identified	identify	VBN
cord-006229-7yoilsho	2082	5	premature	premature	JJ
cord-006229-7yoilsho	2082	6	senescence	senescence	NN
cord-006229-7yoilsho	2082	7	as	as	IN
cord-006229-7yoilsho	2082	8	regulatory	regulatory	JJ
cord-006229-7yoilsho	2082	9	mechanism	mechanism	NN
cord-006229-7yoilsho	2082	10	of	of	IN
cord-006229-7yoilsho	2082	11	tissue	tissue	NN
cord-006229-7yoilsho	2082	12	fibrosis	fibrosis	NN
cord-006229-7yoilsho	2082	13	.	.	.
cord-006229-7yoilsho	2083	1	However	however	RB
cord-006229-7yoilsho	2083	2	,	,	,
cord-006229-7yoilsho	2083	3	its	-PRON-	PRP$
cord-006229-7yoilsho	2083	4	relevance	relevance	NN
cord-006229-7yoilsho	2083	5	in	in	IN
cord-006229-7yoilsho	2083	6	the	the	DT
cord-006229-7yoilsho	2083	7	heart	heart	NN
cord-006229-7yoilsho	2083	8	remains	remain	VBZ
cord-006229-7yoilsho	2083	9	to	to	TO
cord-006229-7yoilsho	2083	10	be	be	VB
cord-006229-7yoilsho	2083	11	established	establish	VBN
cord-006229-7yoilsho	2083	12	.	.	.
cord-006229-7yoilsho	2084	1	Objective	objective	NN
cord-006229-7yoilsho	2084	2	:	:	:
cord-006229-7yoilsho	2085	1	To	to	TO
cord-006229-7yoilsho	2085	2	investigate	investigate	VB
cord-006229-7yoilsho	2085	3	the	the	DT
cord-006229-7yoilsho	2085	4	role	role	NN
cord-006229-7yoilsho	2085	5	of	of	IN
cord-006229-7yoilsho	2085	6	premature	premature	JJ
cord-006229-7yoilsho	2085	7	senescence	senescence	NN
cord-006229-7yoilsho	2085	8	in	in	IN
cord-006229-7yoilsho	2085	9	myocardial	myocardial	JJ
cord-006229-7yoilsho	2085	10	fibrosis	fibrosis	NN
cord-006229-7yoilsho	2085	11	.	.	.
cord-006229-7yoilsho	2086	1	Methods	method	NNS
cord-006229-7yoilsho	2086	2	:	:	:
cord-006229-7yoilsho	2086	3	Murine	murine	JJ
cord-006229-7yoilsho	2086	4	models	model	NNS
cord-006229-7yoilsho	2086	5	of	of	IN
cord-006229-7yoilsho	2086	6	cardiac	cardiac	JJ
cord-006229-7yoilsho	2086	7	disease	disease	NN
cord-006229-7yoilsho	2086	8	and	and	CC
cord-006229-7yoilsho	2086	9	human	human	JJ
cord-006229-7yoilsho	2086	10	heart	heart	NN
cord-006229-7yoilsho	2086	11	biopsies	biopsy	NNS
cord-006229-7yoilsho	2086	12	were	be	VBD
cord-006229-7yoilsho	2086	13	analyzed	analyze	VBN
cord-006229-7yoilsho	2086	14	for	for	IN
cord-006229-7yoilsho	2086	15	characteristics	characteristic	NNS
cord-006229-7yoilsho	2086	16	of	of	IN
cord-006229-7yoilsho	2086	17	premature	premature	JJ
cord-006229-7yoilsho	2086	18	senescence	senescence	NN
cord-006229-7yoilsho	2086	19	and	and	CC
cord-006229-7yoilsho	2086	20	fibrosis	fibrosis	NN
cord-006229-7yoilsho	2086	21	.	.	.
cord-006229-7yoilsho	2087	1	Results	result	NNS
cord-006229-7yoilsho	2087	2	:	:	:
cord-006229-7yoilsho	2088	1	Senescence	senescence	NN
cord-006229-7yoilsho	2088	2	markers	marker	NNS
cord-006229-7yoilsho	2088	3	p21	p21	NN
cord-006229-7yoilsho	2088	4	CIP1/	CIP1/	NNP
cord-006229-7yoilsho	2089	1	WAF1	waf1	JJ
cord-006229-7yoilsho	2089	2	,	,	,
cord-006229-7yoilsho	2089	3	senescence	senescence	NN
cord-006229-7yoilsho	2089	4	-	-	HYPH
cord-006229-7yoilsho	2089	5	associated	associate	VBN
cord-006229-7yoilsho	2089	6	ß	ß	NN
cord-006229-7yoilsho	2089	7	-	-	HYPH
cord-006229-7yoilsho	2089	8	galactosidase	galactosidase	NN
cord-006229-7yoilsho	2089	9	(	(	-LRB-
cord-006229-7yoilsho	2089	10	SA	sa	NN
cord-006229-7yoilsho	2089	11	-	-	HYPH
cord-006229-7yoilsho	2089	12	ß	ß	NN
cord-006229-7yoilsho	2089	13	-	-	HYPH
cord-006229-7yoilsho	2089	14	gal	gal	NN
cord-006229-7yoilsho	2089	15	)	)	-RRB-
cord-006229-7yoilsho	2089	16	and	and	CC
cord-006229-7yoilsho	2090	1	p16	p16	NNS
cord-006229-7yoilsho	2090	2	INK4a	INK4a	NNP
cord-006229-7yoilsho	2090	3	were	be	VBD
cord-006229-7yoilsho	2090	4	increased	increase	VBN
cord-006229-7yoilsho	2091	1	2-	2-	LS
cord-006229-7yoilsho	2091	2	,	,	,
cord-006229-7yoilsho	2091	3	8-and	8-and	LS
cord-006229-7yoilsho	2091	4	20-fold	20-fold	JJ
cord-006229-7yoilsho	2091	5	(	(	-LRB-
cord-006229-7yoilsho	2091	6	n=5	n=5	JJ
cord-006229-7yoilsho	2091	7	-	-	HYPH
cord-006229-7yoilsho	2091	8	7	7	CD
cord-006229-7yoilsho	2091	9	;	;	:
cord-006229-7yoilsho	2091	10	P	p	NN
cord-006229-7yoilsho	2091	11	<	<	XX
cord-006229-7yoilsho	2091	12	0.01	0.01	CD
cord-006229-7yoilsho	2091	13	)	)	-RRB-
cord-006229-7yoilsho	2091	14	,	,	,
cord-006229-7yoilsho	2091	15	respectively	respectively	RB
cord-006229-7yoilsho	2091	16	,	,	,
cord-006229-7yoilsho	2091	17	in	in	IN
cord-006229-7yoilsho	2091	18	perivascular	perivascular	JJ
cord-006229-7yoilsho	2091	19	fibrotic	fibrotic	JJ
cord-006229-7yoilsho	2091	20	areas	area	NNS
cord-006229-7yoilsho	2091	21	after	after	IN
cord-006229-7yoilsho	2091	22	transverse	transverse	JJ
cord-006229-7yoilsho	2091	23	aortic	aortic	JJ
cord-006229-7yoilsho	2091	24	constriction	constriction	NN
cord-006229-7yoilsho	2091	25	(	(	-LRB-
cord-006229-7yoilsho	2091	26	TAC	TAC	NNP
cord-006229-7yoilsho	2091	27	)	)	-RRB-
cord-006229-7yoilsho	2091	28	when	when	WRB
cord-006229-7yoilsho	2091	29	compared	compare	VBN
cord-006229-7yoilsho	2091	30	to	to	IN
cord-006229-7yoilsho	2091	31	sham	sham	NN
cord-006229-7yoilsho	2091	32	-	-	HYPH
cord-006229-7yoilsho	2091	33	treated	treat	VBN
cord-006229-7yoilsho	2091	34	controls	control	NNS
cord-006229-7yoilsho	2091	35	.	.	.
cord-006229-7yoilsho	2092	1	Similar	similar	JJ
cord-006229-7yoilsho	2092	2	results	result	NNS
cord-006229-7yoilsho	2092	3	were	be	VBD
cord-006229-7yoilsho	2092	4	observed	observe	VBN
cord-006229-7yoilsho	2092	5	with	with	IN
cord-006229-7yoilsho	2092	6	cardiomyocytespecific	cardiomyocytespecific	NNP
cord-006229-7yoilsho	2092	7	β1-adrenoceptor	β1-adrenoceptor	NNP
cord-006229-7yoilsho	2092	8	transgenic	transgenic	JJ
cord-006229-7yoilsho	2092	9	mice	mouse	NNS
cord-006229-7yoilsho	2092	10	and	and	CC
cord-006229-7yoilsho	2092	11	human	human	JJ
cord-006229-7yoilsho	2092	12	heart	heart	NN
cord-006229-7yoilsho	2092	13	biopsies	biopsy	NNS
cord-006229-7yoilsho	2092	14	.	.	.
cord-006229-7yoilsho	2093	1	Senescent	senescent	NN
cord-006229-7yoilsho	2093	2	cells	cell	NNS
cord-006229-7yoilsho	2093	3	were	be	VBD
cord-006229-7yoilsho	2093	4	positive	positive	JJ
cord-006229-7yoilsho	2093	5	for	for	IN
cord-006229-7yoilsho	2093	6	vimentin	vimentin	NNS
cord-006229-7yoilsho	2093	7	(	(	-LRB-
cord-006229-7yoilsho	2093	8	92	92	CD
cord-006229-7yoilsho	2093	9	±	±	CD
cord-006229-7yoilsho	2093	10	0.9	0.9	CD
cord-006229-7yoilsho	2093	11	%	%	NN
cord-006229-7yoilsho	2093	12	)	)	-RRB-
cord-006229-7yoilsho	2093	13	,	,	,
cord-006229-7yoilsho	2093	14	platelet	platelet	NN
cord-006229-7yoilsho	2093	15	derived	derive	VBN
cord-006229-7yoilsho	2093	16	growth	growth	NN
cord-006229-7yoilsho	2093	17	factor	factor	NN
cord-006229-7yoilsho	2093	18	receptor	receptor	NN
cord-006229-7yoilsho	2093	19	α	α	NNP
cord-006229-7yoilsho	2093	20	(	(	-LRB-
cord-006229-7yoilsho	2093	21	94	94	CD
cord-006229-7yoilsho	2093	22	±	±	CD
cord-006229-7yoilsho	2093	23	0.9	0.9	CD
cord-006229-7yoilsho	2093	24	%	%	NN
cord-006229-7yoilsho	2093	25	)	)	-RRB-
cord-006229-7yoilsho	2093	26	and	and	CC
cord-006229-7yoilsho	2093	27	α	α	NN
cord-006229-7yoilsho	2093	28	-	-	HYPH
cord-006229-7yoilsho	2093	29	smooth	smooth	JJ
cord-006229-7yoilsho	2093	30	muscle	muscle	NN
cord-006229-7yoilsho	2093	31	actin	actin	NN
cord-006229-7yoilsho	2093	32	(	(	-LRB-
cord-006229-7yoilsho	2093	33	71	71	CD
cord-006229-7yoilsho	2093	34	±	±	CD
cord-006229-7yoilsho	2093	35	2.3	2.3	CD
cord-006229-7yoilsho	2093	36	%	%	NN
cord-006229-7yoilsho	2093	37	)	)	-RRB-
cord-006229-7yoilsho	2093	38	,	,	,
cord-006229-7yoilsho	2093	39	specifying	specify	VBG
cord-006229-7yoilsho	2093	40	myofibroblasts	myofibroblast	NNS
cord-006229-7yoilsho	2093	41	as	as	IN
cord-006229-7yoilsho	2093	42	the	the	DT
cord-006229-7yoilsho	2093	43	predominant	predominant	JJ
cord-006229-7yoilsho	2093	44	cell	cell	NN
cord-006229-7yoilsho	2093	45	population	population	NN
cord-006229-7yoilsho	2093	46	undergoing	undergo	VBG
cord-006229-7yoilsho	2093	47	premature	premature	JJ
cord-006229-7yoilsho	2093	48	senescence	senescence	NN
cord-006229-7yoilsho	2093	49	in	in	IN
cord-006229-7yoilsho	2093	50	the	the	DT
cord-006229-7yoilsho	2093	51	heart	heart	NN
cord-006229-7yoilsho	2093	52	.	.	.
cord-006229-7yoilsho	2094	1	Conclusion	conclusion	NN
cord-006229-7yoilsho	2094	2	:	:	:
cord-006229-7yoilsho	2095	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	2095	2	data	datum	NNS
cord-006229-7yoilsho	2095	3	provide	provide	VBP
cord-006229-7yoilsho	2095	4	first	first	JJ
cord-006229-7yoilsho	2095	5	evidence	evidence	NN
cord-006229-7yoilsho	2095	6	for	for	IN
cord-006229-7yoilsho	2095	7	an	an	DT
cord-006229-7yoilsho	2095	8	essential	essential	JJ
cord-006229-7yoilsho	2095	9	role	role	NN
cord-006229-7yoilsho	2095	10	of	of	IN
cord-006229-7yoilsho	2095	11	premature	premature	JJ
cord-006229-7yoilsho	2095	12	senescence	senescence	NN
cord-006229-7yoilsho	2095	13	of	of	IN
cord-006229-7yoilsho	2095	14	myofibroblasts	myofibroblast	NNS
cord-006229-7yoilsho	2095	15	in	in	IN
cord-006229-7yoilsho	2095	16	myocardial	myocardial	JJ
cord-006229-7yoilsho	2095	17	fibrosis	fibrosis	NN
cord-006229-7yoilsho	2095	18	.	.	.
cord-006229-7yoilsho	2096	1	It	-PRON-	PRP
cord-006229-7yoilsho	2096	2	is	be	VBZ
cord-006229-7yoilsho	2096	3	tempting	tempt	VBG
cord-006229-7yoilsho	2096	4	to	to	TO
cord-006229-7yoilsho	2096	5	speculate	speculate	VB
cord-006229-7yoilsho	2096	6	that	that	IN
cord-006229-7yoilsho	2096	7	pharmacologic	pharmacologic	JJ
cord-006229-7yoilsho	2096	8	modulation	modulation	NN
cord-006229-7yoilsho	2096	9	of	of	IN
cord-006229-7yoilsho	2096	10	premature	premature	JJ
cord-006229-7yoilsho	2096	11	senescence	senescence	NN
cord-006229-7yoilsho	2096	12	might	may	MD
cord-006229-7yoilsho	2096	13	provide	provide	VB
cord-006229-7yoilsho	2096	14	a	a	DT
cord-006229-7yoilsho	2096	15	novel	novel	JJ
cord-006229-7yoilsho	2096	16	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	2096	17	target	target	NN
cord-006229-7yoilsho	2096	18	for	for	IN
cord-006229-7yoilsho	2096	19	anti	anti	JJ
cord-006229-7yoilsho	2096	20	-	-	JJ
cord-006229-7yoilsho	2096	21	fibrotic	fibrotic	JJ
cord-006229-7yoilsho	2096	22	therapies	therapy	NNS
cord-006229-7yoilsho	2096	23	in	in	IN
cord-006229-7yoilsho	2096	24	the	the	DT
cord-006229-7yoilsho	2096	25	heart	heart	NN
cord-006229-7yoilsho	2096	26	.	.	.
cord-006229-7yoilsho	2097	1	Introduction	introduction	NN
cord-006229-7yoilsho	2097	2	:	:	:
cord-006229-7yoilsho	2098	1	The	the	DT
cord-006229-7yoilsho	2098	2	endocannabinoid	endocannabinoid	NN
cord-006229-7yoilsho	2098	3	system	system	NN
cord-006229-7yoilsho	2098	4	is	be	VBZ
cord-006229-7yoilsho	2098	5	increasingly	increasingly	RB
cord-006229-7yoilsho	2098	6	studied	study	VBN
cord-006229-7yoilsho	2098	7	in	in	IN
cord-006229-7yoilsho	2098	8	cardiac	cardiac	JJ
cord-006229-7yoilsho	2098	9	research	research	NN
cord-006229-7yoilsho	2098	10	due	due	IN
cord-006229-7yoilsho	2098	11	to	to	IN
cord-006229-7yoilsho	2098	12	its	-PRON-	PRP$
cord-006229-7yoilsho	2098	13	role	role	NN
cord-006229-7yoilsho	2098	14	in	in	IN
cord-006229-7yoilsho	2098	15	fibrosis	fibrosis	NN
cord-006229-7yoilsho	2098	16	,	,	,
cord-006229-7yoilsho	2098	17	inflammation	inflammation	NN
cord-006229-7yoilsho	2098	18	and	and	CC
cord-006229-7yoilsho	2098	19	cell	cell	NN
cord-006229-7yoilsho	2098	20	fate	fate	NN
cord-006229-7yoilsho	2098	21	modulation	modulation	NN
cord-006229-7yoilsho	2098	22	.	.	.
cord-006229-7yoilsho	2099	1	The	the	DT
cord-006229-7yoilsho	2099	2	deregulation	deregulation	NN
cord-006229-7yoilsho	2099	3	of	of	IN
cord-006229-7yoilsho	2099	4	this	this	DT
cord-006229-7yoilsho	2099	5	system	system	NN
cord-006229-7yoilsho	2099	6	has	have	VBZ
cord-006229-7yoilsho	2099	7	been	be	VBN
cord-006229-7yoilsho	2099	8	implicated	implicate	VBN
cord-006229-7yoilsho	2099	9	in	in	IN
cord-006229-7yoilsho	2099	10	myocardial	myocardial	JJ
cord-006229-7yoilsho	2099	11	infarction	infarction	NN
cord-006229-7yoilsho	2099	12	(	(	-LRB-
cord-006229-7yoilsho	2099	13	MI	MI	NNP
cord-006229-7yoilsho	2099	14	)	)	-RRB-
cord-006229-7yoilsho	2099	15	and	and	CC
cord-006229-7yoilsho	2099	16	consequent	consequent	JJ
cord-006229-7yoilsho	2099	17	heart	heart	NN
cord-006229-7yoilsho	2099	18	failure	failure	NN
cord-006229-7yoilsho	2099	19	development	development	NN
cord-006229-7yoilsho	2099	20	.	.	.
cord-006229-7yoilsho	2100	1	A	a	DT
cord-006229-7yoilsho	2100	2	recent	recent	JJ
cord-006229-7yoilsho	2100	3	study	study	NN
cord-006229-7yoilsho	2100	4	suggests	suggest	VBZ
cord-006229-7yoilsho	2100	5	cannabinoid	cannabinoid	NN
cord-006229-7yoilsho	2100	6	receptor	receptor	NN
cord-006229-7yoilsho	2100	7	1	1	CD
cord-006229-7yoilsho	2100	8	(	(	-LRB-
cord-006229-7yoilsho	2100	9	CB1	cb1	NN
cord-006229-7yoilsho	2100	10	)	)	-RRB-
cord-006229-7yoilsho	2100	11	inhibition	inhibition	NN
cord-006229-7yoilsho	2100	12	to	to	TO
cord-006229-7yoilsho	2100	13	improve	improve	VB
cord-006229-7yoilsho	2100	14	cardiac	cardiac	JJ
cord-006229-7yoilsho	2100	15	function	function	NN
cord-006229-7yoilsho	2100	16	and	and	CC
cord-006229-7yoilsho	2100	17	to	to	TO
cord-006229-7yoilsho	2100	18	reduce	reduce	VB
cord-006229-7yoilsho	2100	19	adverse	adverse	JJ
cord-006229-7yoilsho	2100	20	remodeling	remodeling	NN
cord-006229-7yoilsho	2100	21	after	after	IN
cord-006229-7yoilsho	2100	22	cardiac	cardiac	JJ
cord-006229-7yoilsho	2100	23	stress	stress	NN
cord-006229-7yoilsho	2100	24	,	,	,
cord-006229-7yoilsho	2100	25	but	but	CC
cord-006229-7yoilsho	2100	26	the	the	DT
cord-006229-7yoilsho	2100	27	exact	exact	JJ
cord-006229-7yoilsho	2100	28	underlying	underlying	JJ
cord-006229-7yoilsho	2100	29	molecular	molecular	JJ
cord-006229-7yoilsho	2100	30	mechanisms	mechanism	NNS
cord-006229-7yoilsho	2100	31	of	of	IN
cord-006229-7yoilsho	2100	32	these	these	DT
cord-006229-7yoilsho	2100	33	beneficial	beneficial	JJ
cord-006229-7yoilsho	2100	34	effects	effect	NNS
cord-006229-7yoilsho	2100	35	are	be	VBP
cord-006229-7yoilsho	2100	36	still	still	RB
cord-006229-7yoilsho	2100	37	unknown	unknown	JJ
cord-006229-7yoilsho	2100	38	.	.	.
cord-006229-7yoilsho	2101	1	MicroRNAs	MicroRNAs	NNP
cord-006229-7yoilsho	2102	1	(	(	-LRB-
cord-006229-7yoilsho	2102	2	miRNAs	miRNAs	NNP
cord-006229-7yoilsho	2102	3	,	,	,
cord-006229-7yoilsho	2102	4	miRs	miRs	NNP
cord-006229-7yoilsho	2102	5	)	)	-RRB-
cord-006229-7yoilsho	2102	6	provide	provide	VB
cord-006229-7yoilsho	2102	7	a	a	DT
cord-006229-7yoilsho	2102	8	complex	complex	JJ
cord-006229-7yoilsho	2102	9	layer	layer	NN
cord-006229-7yoilsho	2102	10	of	of	IN
cord-006229-7yoilsho	2102	11	post	post	JJ
cord-006229-7yoilsho	2102	12	-	-	JJ
cord-006229-7yoilsho	2102	13	transcriptional	transcriptional	JJ
cord-006229-7yoilsho	2102	14	regulation	regulation	NN
cord-006229-7yoilsho	2102	15	modulating	modulate	VBG
cord-006229-7yoilsho	2102	16	key	key	JJ
cord-006229-7yoilsho	2102	17	biological	biological	JJ
cord-006229-7yoilsho	2102	18	processes	process	NNS
cord-006229-7yoilsho	2102	19	such	such	JJ
cord-006229-7yoilsho	2102	20	as	as	IN
cord-006229-7yoilsho	2102	21	tissue	tissue	NN
cord-006229-7yoilsho	2102	22	remodelling	remodelling	NN
cord-006229-7yoilsho	2102	23	in	in	IN
cord-006229-7yoilsho	2102	24	heart	heart	NN
cord-006229-7yoilsho	2102	25	failure	failure	NN
cord-006229-7yoilsho	2102	26	.	.	.
cord-006229-7yoilsho	2103	1	The	the	DT
cord-006229-7yoilsho	2103	2	aim	aim	NN
cord-006229-7yoilsho	2103	3	of	of	IN
cord-006229-7yoilsho	2103	4	the	the	DT
cord-006229-7yoilsho	2103	5	present	present	JJ
cord-006229-7yoilsho	2103	6	study	study	NN
cord-006229-7yoilsho	2103	7	was	be	VBD
cord-006229-7yoilsho	2103	8	to	to	TO
cord-006229-7yoilsho	2103	9	explore	explore	VB
cord-006229-7yoilsho	2103	10	microRNA	microRNA	NNP
cord-006229-7yoilsho	2103	11	pathways	pathway	NNS
cord-006229-7yoilsho	2103	12	in	in	IN
cord-006229-7yoilsho	2103	13	the	the	DT
cord-006229-7yoilsho	2103	14	chronic	chronic	JJ
cord-006229-7yoilsho	2103	15	effect	effect	NN
cord-006229-7yoilsho	2103	16	of	of	IN
cord-006229-7yoilsho	2103	17	CB1	cb1	NN
cord-006229-7yoilsho	2103	18	receptor	receptor	NN
cord-006229-7yoilsho	2103	19	inhibition	inhibition	NN
cord-006229-7yoilsho	2103	20	after	after	IN
cord-006229-7yoilsho	2103	21	angiotensin	angiotensin	NN
cord-006229-7yoilsho	2103	22	-	-	HYPH
cord-006229-7yoilsho	2103	23	fibrosis	fibrosis	NN
cord-006229-7yoilsho	2103	24	induction	induction	NN
cord-006229-7yoilsho	2103	25	and	and	CC
cord-006229-7yoilsho	2103	26	left	leave	VBD
cord-006229-7yoilsho	2103	27	ventricular	ventricular	JJ
cord-006229-7yoilsho	2103	28	remodeling	remodeling	NN
cord-006229-7yoilsho	2103	29	.	.	.
cord-006229-7yoilsho	2104	1	Methods	method	NNS
cord-006229-7yoilsho	2104	2	and	and	CC
cord-006229-7yoilsho	2104	3	Results	result	NNS
cord-006229-7yoilsho	2104	4	:	:	:
cord-006229-7yoilsho	2104	5	Adverse	adverse	JJ
cord-006229-7yoilsho	2104	6	cardiac	cardiac	JJ
cord-006229-7yoilsho	2104	7	remodelling	remodelling	NN
cord-006229-7yoilsho	2104	8	was	be	VBD
cord-006229-7yoilsho	2104	9	induced	induce	VBN
cord-006229-7yoilsho	2104	10	in	in	IN
cord-006229-7yoilsho	2104	11	mice	mouse	NNS
cord-006229-7yoilsho	2104	12	by	by	IN
cord-006229-7yoilsho	2104	13	chronic	chronic	JJ
cord-006229-7yoilsho	2104	14	administration	administration	NN
cord-006229-7yoilsho	2104	15	of	of	IN
cord-006229-7yoilsho	2104	16	Angiotensin	Angiotensin	NNP
cord-006229-7yoilsho	2104	17	II	II	NNP
cord-006229-7yoilsho	2104	18	(	(	-LRB-
cord-006229-7yoilsho	2104	19	AngII	AngII	NNP
cord-006229-7yoilsho	2104	20	,	,	,
cord-006229-7yoilsho	2104	21	1,5	1,5	CD
cord-006229-7yoilsho	2104	22	mg	mg	NNP
cord-006229-7yoilsho	2104	23	/	/	SYM
cord-006229-7yoilsho	2104	24	kg	kg	NNP
cord-006229-7yoilsho	2104	25	/	/	SYM
cord-006229-7yoilsho	2104	26	day	day	NN
cord-006229-7yoilsho	2104	27	)	)	-RRB-
cord-006229-7yoilsho	2104	28	with	with	IN
cord-006229-7yoilsho	2104	29	osmotic	osmotic	JJ
cord-006229-7yoilsho	2104	30	minipumps	minipump	NNS
cord-006229-7yoilsho	2104	31	for	for	IN
cord-006229-7yoilsho	2104	32	14	14	CD
cord-006229-7yoilsho	2104	33	days	day	NNS
cord-006229-7yoilsho	2104	34	.	.	.
cord-006229-7yoilsho	2105	1	Treatment	treatment	NN
cord-006229-7yoilsho	2105	2	with	with	IN
cord-006229-7yoilsho	2105	3	CB1	cb1	NN
cord-006229-7yoilsho	2105	4	antagonist	antagonist	NN
cord-006229-7yoilsho	2105	5	,	,	,
cord-006229-7yoilsho	2105	6	or	or	CC
cord-006229-7yoilsho	2105	7	vehicle	vehicle	NN
cord-006229-7yoilsho	2105	8	was	be	VBD
cord-006229-7yoilsho	2105	9	performed	perform	VBN
cord-006229-7yoilsho	2105	10	every	every	DT
cord-006229-7yoilsho	2105	11	second	second	JJ
cord-006229-7yoilsho	2105	12	day	day	NN
cord-006229-7yoilsho	2105	13	during	during	IN
cord-006229-7yoilsho	2105	14	the	the	DT
cord-006229-7yoilsho	2105	15	AngII	AngII	NNP
cord-006229-7yoilsho	2105	16	administration	administration	NN
cord-006229-7yoilsho	2105	17	period	period	NN
cord-006229-7yoilsho	2105	18	.	.	.
cord-006229-7yoilsho	2106	1	Hemodynamic	Hemodynamic	NNP
cord-006229-7yoilsho	2106	2	parameters	parameter	NNS
cord-006229-7yoilsho	2106	3	were	be	VBD
cord-006229-7yoilsho	2106	4	measured	measure	VBN
cord-006229-7yoilsho	2106	5	by	by	IN
cord-006229-7yoilsho	2106	6	echocardiography	echocardiography	NN
cord-006229-7yoilsho	2106	7	and	and	CC
cord-006229-7yoilsho	2106	8	cardiac	cardiac	JJ
cord-006229-7yoilsho	2106	9	pressure	pressure	NN
cord-006229-7yoilsho	2106	10	volume	volume	NN
cord-006229-7yoilsho	2106	11	catheter	catheter	NN
cord-006229-7yoilsho	2106	12	and	and	CC
cord-006229-7yoilsho	2106	13	tissue	tissue	NN
cord-006229-7yoilsho	2106	14	samples	sample	NNS
cord-006229-7yoilsho	2106	15	were	be	VBD
cord-006229-7yoilsho	2106	16	taken	take	VBN
cord-006229-7yoilsho	2106	17	for	for	IN
cord-006229-7yoilsho	2106	18	molecular	molecular	JJ
cord-006229-7yoilsho	2106	19	and	and	CC
cord-006229-7yoilsho	2106	20	histological	histological	JJ
cord-006229-7yoilsho	2106	21	analysis	analysis	NN
cord-006229-7yoilsho	2106	22	.	.	.
cord-006229-7yoilsho	2107	1	After	after	IN
cord-006229-7yoilsho	2107	2	two	two	CD
cord-006229-7yoilsho	2107	3	weeks	week	NNS
cord-006229-7yoilsho	2107	4	of	of	IN
cord-006229-7yoilsho	2107	5	AngII	AngII	NNP
cord-006229-7yoilsho	2107	6	infusion	infusion	NN
cord-006229-7yoilsho	2107	7	,	,	,
cord-006229-7yoilsho	2107	8	left	leave	VBD
cord-006229-7yoilsho	2107	9	ventricular	ventricular	JJ
cord-006229-7yoilsho	2107	10	dysfunction	dysfunction	NN
cord-006229-7yoilsho	2107	11	was	be	VBD
cord-006229-7yoilsho	2107	12	prevented	prevent	VBN
cord-006229-7yoilsho	2107	13	by	by	IN
cord-006229-7yoilsho	2107	14	CB1	CB1	NNP
cord-006229-7yoilsho	2107	15	antagonist	antagonist	NN
cord-006229-7yoilsho	2107	16	treatment	treatment	NN
cord-006229-7yoilsho	2107	17	.	.	.
cord-006229-7yoilsho	2108	1	This	this	DT
cord-006229-7yoilsho	2108	2	was	be	VBD
cord-006229-7yoilsho	2108	3	shown	show	VBN
cord-006229-7yoilsho	2108	4	by	by	IN
cord-006229-7yoilsho	2108	5	significantly	significantly	JJ
cord-006229-7yoilsho	2108	6	improvements	improvement	NNS
cord-006229-7yoilsho	2108	7	of	of	IN
cord-006229-7yoilsho	2108	8	the	the	DT
cord-006229-7yoilsho	2108	9	myocardial	myocardial	JJ
cord-006229-7yoilsho	2108	10	performance	performance	NN
cord-006229-7yoilsho	2108	11	index	index	NN
cord-006229-7yoilsho	2108	12	and	and	CC
cord-006229-7yoilsho	2108	13	end	end	NN
cord-006229-7yoilsho	2108	14	-	-	HYPH
cord-006229-7yoilsho	2108	15	diastolic	diastolic	JJ
cord-006229-7yoilsho	2108	16	pressure	pressure	NN
cord-006229-7yoilsho	2108	17	values	value	NNS
cord-006229-7yoilsho	2108	18	.	.	.
cord-006229-7yoilsho	2109	1	At	at	IN
cord-006229-7yoilsho	2109	2	the	the	DT
cord-006229-7yoilsho	2109	3	tissue	tissue	NN
cord-006229-7yoilsho	2109	4	level	level	NN
cord-006229-7yoilsho	2109	5	,	,	,
cord-006229-7yoilsho	2109	6	anti	anti	JJ
cord-006229-7yoilsho	2109	7	-	-	JJ
cord-006229-7yoilsho	2109	8	fibrotic	fibrotic	JJ
cord-006229-7yoilsho	2109	9	effects	effect	NNS
cord-006229-7yoilsho	2109	10	of	of	IN
cord-006229-7yoilsho	2109	11	CB1	CB1	NNP
cord-006229-7yoilsho	2109	12	antagonist	antagonist	NN
cord-006229-7yoilsho	2109	13	treatment	treatment	NN
cord-006229-7yoilsho	2109	14	was	be	VBD
cord-006229-7yoilsho	2109	15	confirmed	confirm	VBN
cord-006229-7yoilsho	2109	16	histologically	histologically	RB
cord-006229-7yoilsho	2109	17	and	and	CC
cord-006229-7yoilsho	2109	18	by	by	IN
cord-006229-7yoilsho	2109	19	expression	expression	NN
cord-006229-7yoilsho	2109	20	analysis	analysis	NN
cord-006229-7yoilsho	2109	21	of	of	IN
cord-006229-7yoilsho	2109	22	pro	pro	JJ
cord-006229-7yoilsho	2109	23	-	-	JJ
cord-006229-7yoilsho	2109	24	fibrotic	fibrotic	JJ
cord-006229-7yoilsho	2109	25	genes	gene	NNS
cord-006229-7yoilsho	2109	26	.	.	.
cord-006229-7yoilsho	2110	1	These	these	DT
cord-006229-7yoilsho	2110	2	beneficial	beneficial	JJ
cord-006229-7yoilsho	2110	3	effects	effect	NNS
cord-006229-7yoilsho	2110	4	were	be	VBD
cord-006229-7yoilsho	2110	5	also	also	RB
cord-006229-7yoilsho	2110	6	observed	observe	VBN
cord-006229-7yoilsho	2110	7	in	in	IN
cord-006229-7yoilsho	2110	8	CB1	CB1	NNP
cord-006229-7yoilsho	2110	9	KO	KO	NNP
cord-006229-7yoilsho	2110	10	mice	mouse	NNS
cord-006229-7yoilsho	2110	11	and	and	CC
cord-006229-7yoilsho	2110	12	in	in	IN
cord-006229-7yoilsho	2110	13	an	an	DT
cord-006229-7yoilsho	2110	14	aging	age	VBG
cord-006229-7yoilsho	2110	15	mice	mice	NN
cord-006229-7yoilsho	2110	16	model	model	NN
cord-006229-7yoilsho	2110	17	.	.	.
cord-006229-7yoilsho	2111	1	The	the	DT
cord-006229-7yoilsho	2111	2	particular	particular	JJ
cord-006229-7yoilsho	2111	3	role	role	NN
cord-006229-7yoilsho	2111	4	of	of	IN
cord-006229-7yoilsho	2111	5	tissue	tissue	NN
cord-006229-7yoilsho	2111	6	fibroblast	fibroblast	NN
cord-006229-7yoilsho	2111	7	in	in	IN
cord-006229-7yoilsho	2111	8	AII	AII	NNP
cord-006229-7yoilsho	2111	9	-	-	HYPH
cord-006229-7yoilsho	2111	10	induced	induce	VBN
cord-006229-7yoilsho	2111	11	cardiac	cardiac	JJ
cord-006229-7yoilsho	2111	12	fibrosis	fibrosis	NN
cord-006229-7yoilsho	2111	13	was	be	VBD
cord-006229-7yoilsho	2111	14	further	further	RB
cord-006229-7yoilsho	2111	15	explored	explore	VBN
cord-006229-7yoilsho	2111	16	.	.	.
cord-006229-7yoilsho	2112	1	Primary	primary	JJ
cord-006229-7yoilsho	2112	2	cardiac	cardiac	JJ
cord-006229-7yoilsho	2112	3	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	2112	4	(	(	-LRB-
cord-006229-7yoilsho	2112	5	CF	CF	NNP
cord-006229-7yoilsho	2112	6	)	)	-RRB-
cord-006229-7yoilsho	2112	7	from	from	IN
cord-006229-7yoilsho	2112	8	each	each	DT
cord-006229-7yoilsho	2112	9	experimental	experimental	JJ
cord-006229-7yoilsho	2112	10	group	group	NN
cord-006229-7yoilsho	2112	11	were	be	VBD
cord-006229-7yoilsho	2112	12	isolated	isolate	VBN
cord-006229-7yoilsho	2112	13	and	and	CC
cord-006229-7yoilsho	2112	14	analysed	analyse	VBN
cord-006229-7yoilsho	2112	15	by	by	IN
cord-006229-7yoilsho	2112	16	next	next	JJ
cord-006229-7yoilsho	2112	17	generation	generation	NN
cord-006229-7yoilsho	2112	18	deep	deep	JJ
cord-006229-7yoilsho	2112	19	RNA	RNA	NNP
cord-006229-7yoilsho	2112	20	sequencing	sequencing	NN
cord-006229-7yoilsho	2112	21	to	to	TO
cord-006229-7yoilsho	2112	22	identify	identify	VB
cord-006229-7yoilsho	2112	23	differentially	differentially	RB
cord-006229-7yoilsho	2112	24	regulated	regulate	VBN
cord-006229-7yoilsho	2112	25	microRNAs	microrna	NNS
cord-006229-7yoilsho	2112	26	.	.	.
cord-006229-7yoilsho	2113	1	MicroRNA-181a	MicroRNA-181a	NNP
cord-006229-7yoilsho	2113	2	/	/	SYM
cord-006229-7yoilsho	2113	3	b	b	LS
cord-006229-7yoilsho	2113	4	family	family	NN
cord-006229-7yoilsho	2113	5	was	be	VBD
cord-006229-7yoilsho	2113	6	downregulated	downregulate	VBN
cord-006229-7yoilsho	2113	7	by	by	IN
cord-006229-7yoilsho	2113	8	in	in	IN
cord-006229-7yoilsho	2113	9	vivo	vivo	NNP
cord-006229-7yoilsho	2113	10	AngII	AngII	NNP
cord-006229-7yoilsho	2113	11	delivery	delivery	NN
cord-006229-7yoilsho	2113	12	and	and	CC
cord-006229-7yoilsho	2113	13	vice	vice	NN
cord-006229-7yoilsho	2113	14	versa	versa	RB
cord-006229-7yoilsho	2113	15	upregulated	upregulate	VBN
cord-006229-7yoilsho	2113	16	after	after	IN
cord-006229-7yoilsho	2113	17	CB1	CB1	NNP
cord-006229-7yoilsho	2113	18	antagonist	antagonist	NN
cord-006229-7yoilsho	2113	19	treatment	treatment	NN
cord-006229-7yoilsho	2113	20	and	and	CC
cord-006229-7yoilsho	2114	1	Foxb1	Foxb1	NNP
cord-006229-7yoilsho	2114	2	(	(	-LRB-
cord-006229-7yoilsho	2114	3	a	a	DT
cord-006229-7yoilsho	2114	4	direct	direct	JJ
cord-006229-7yoilsho	2114	5	target	target	NN
cord-006229-7yoilsho	2114	6	of	of	IN
cord-006229-7yoilsho	2114	7	miR-181a	mir-181a	CD
cord-006229-7yoilsho	2114	8	family	family	NN
cord-006229-7yoilsho	2114	9	)	)	-RRB-
cord-006229-7yoilsho	2114	10	was	be	VBD
cord-006229-7yoilsho	2114	11	differentially	differentially	RB
cord-006229-7yoilsho	2114	12	regulated	regulate	VBN
cord-006229-7yoilsho	2114	13	,	,	,
cord-006229-7yoilsho	2114	14	suggesting	suggest	VBG
cord-006229-7yoilsho	2114	15	a	a	DT
cord-006229-7yoilsho	2114	16	possible	possible	JJ
cord-006229-7yoilsho	2114	17	mechanism	mechanism	NN
cord-006229-7yoilsho	2114	18	of	of	IN
cord-006229-7yoilsho	2114	19	action	action	NN
cord-006229-7yoilsho	2114	20	for	for	IN
cord-006229-7yoilsho	2114	21	the	the	DT
cord-006229-7yoilsho	2114	22	benefits	benefit	NNS
cord-006229-7yoilsho	2114	23	of	of	IN
cord-006229-7yoilsho	2114	24	CB1	cb1	NN
cord-006229-7yoilsho	2114	25	receptor	receptor	NN
cord-006229-7yoilsho	2114	26	inhibition	inhibition	NN
cord-006229-7yoilsho	2114	27	.	.	.
cord-006229-7yoilsho	2115	1	Conclusion	conclusion	NN
cord-006229-7yoilsho	2115	2	:	:	:
cord-006229-7yoilsho	2115	3	We	-PRON-	PRP
cord-006229-7yoilsho	2115	4	found	find	VBD
cord-006229-7yoilsho	2115	5	that	that	IN
cord-006229-7yoilsho	2115	6	in	in	IN
cord-006229-7yoilsho	2115	7	AngII	AngII	NNP
cord-006229-7yoilsho	2115	8	-	-	HYPH
cord-006229-7yoilsho	2115	9	induced	induce	VBN
cord-006229-7yoilsho	2115	10	cardiac	cardiac	JJ
cord-006229-7yoilsho	2115	11	remodelling	remodelling	NN
cord-006229-7yoilsho	2115	12	,	,	,
cord-006229-7yoilsho	2115	13	LV	LV	NNP
cord-006229-7yoilsho	2115	14	function	function	NN
cord-006229-7yoilsho	2115	15	is	be	VBZ
cord-006229-7yoilsho	2115	16	preserved	preserve	VBN
cord-006229-7yoilsho	2115	17	by	by	IN
cord-006229-7yoilsho	2115	18	chronic	chronic	JJ
cord-006229-7yoilsho	2115	19	CB1	CB1	NNP
cord-006229-7yoilsho	2115	20	antagonist	antagonist	NN
cord-006229-7yoilsho	2115	21	treatment	treatment	NN
cord-006229-7yoilsho	2115	22	and	and	CC
cord-006229-7yoilsho	2115	23	that	that	IN
cord-006229-7yoilsho	2115	24	cardiac	cardiac	JJ
cord-006229-7yoilsho	2115	25	fibrosis	fibrosis	NN
cord-006229-7yoilsho	2115	26	is	be	VBZ
cord-006229-7yoilsho	2115	27	reduced	reduce	VBN
cord-006229-7yoilsho	2115	28	with	with	IN
cord-006229-7yoilsho	2115	29	concomitant	concomitant	JJ
cord-006229-7yoilsho	2115	30	downregulation	downregulation	NN
cord-006229-7yoilsho	2115	31	of	of	IN
cord-006229-7yoilsho	2115	32	fibrogenic	fibrogenic	NNP
cord-006229-7yoilsho	2115	33	genes	gene	NNS
cord-006229-7yoilsho	2115	34	.	.	.
cord-006229-7yoilsho	2116	1	Also	also	RB
cord-006229-7yoilsho	2116	2	,	,	,
cord-006229-7yoilsho	2116	3	CF	cf	NN
cord-006229-7yoilsho	2116	4	-	-	HYPH
cord-006229-7yoilsho	2116	5	enriched	enrich	VBN
cord-006229-7yoilsho	2116	6	miR-181a	mir-181a	CD
cord-006229-7yoilsho	2116	7	/	/	SYM
cord-006229-7yoilsho	2116	8	b	b	NN
cord-006229-7yoilsho	2116	9	family	family	NN
cord-006229-7yoilsho	2116	10	seems	seem	VBZ
cord-006229-7yoilsho	2116	11	to	to	TO
cord-006229-7yoilsho	2116	12	be	be	VB
cord-006229-7yoilsho	2116	13	sensitive	sensitive	JJ
cord-006229-7yoilsho	2116	14	to	to	IN
cord-006229-7yoilsho	2116	15	CB1	cb1	NN
cord-006229-7yoilsho	2116	16	antagonist	antagonist	NN
cord-006229-7yoilsho	2116	17	treatment	treatment	NN
cord-006229-7yoilsho	2116	18	,	,	,
cord-006229-7yoilsho	2116	19	thereby	thereby	RB
cord-006229-7yoilsho	2116	20	affecting	affect	VBG
cord-006229-7yoilsho	2116	21	cardiac	cardiac	JJ
cord-006229-7yoilsho	2116	22	fibrosis	fibrosis	NN
cord-006229-7yoilsho	2116	23	.	.	.
cord-006229-7yoilsho	2117	1	The	the	DT
cord-006229-7yoilsho	2117	2	current	current	JJ
cord-006229-7yoilsho	2117	3	study	study	NN
cord-006229-7yoilsho	2117	4	employs	employ	VBZ
cord-006229-7yoilsho	2117	5	a	a	DT
cord-006229-7yoilsho	2117	6	novel	novel	JJ
cord-006229-7yoilsho	2117	7	concept	concept	NN
cord-006229-7yoilsho	2117	8	regarding	regard	VBG
cord-006229-7yoilsho	2117	9	chronic	chronic	JJ
cord-006229-7yoilsho	2117	10	CB1	CB1	NNP
cord-006229-7yoilsho	2117	11	inhibitor	inhibitor	NN
cord-006229-7yoilsho	2117	12	treatment	treatment	NN
cord-006229-7yoilsho	2117	13	and	and	CC
cord-006229-7yoilsho	2117	14	may	may	MD
cord-006229-7yoilsho	2117	15	provide	provide	VB
cord-006229-7yoilsho	2117	16	important	important	JJ
cord-006229-7yoilsho	2117	17	details	detail	NNS
cord-006229-7yoilsho	2117	18	and	and	CC
cord-006229-7yoilsho	2117	19	novel	novel	JJ
cord-006229-7yoilsho	2117	20	targets	target	NNS
cord-006229-7yoilsho	2117	21	for	for	IN
cord-006229-7yoilsho	2117	22	anti	anti	JJ
cord-006229-7yoilsho	2117	23	-	-	JJ
cord-006229-7yoilsho	2117	24	fibrotic	fibrotic	JJ
cord-006229-7yoilsho	2117	25	approaches	approach	NNS
cord-006229-7yoilsho	2117	26	in	in	IN
cord-006229-7yoilsho	2117	27	heart	heart	NN
cord-006229-7yoilsho	2117	28	failure	failure	NN
cord-006229-7yoilsho	2117	29	.	.	.
cord-006229-7yoilsho	2118	1	Background	background	NN
cord-006229-7yoilsho	2118	2	:	:	:
cord-006229-7yoilsho	2119	1	Low	low	JJ
cord-006229-7yoilsho	2119	2	homoarginine	homoarginine	NN
cord-006229-7yoilsho	2119	3	(	(	-LRB-
cord-006229-7yoilsho	2119	4	hArg	hArg	NNP
cord-006229-7yoilsho	2119	5	)	)	-RRB-
cord-006229-7yoilsho	2119	6	was	be	VBD
cord-006229-7yoilsho	2119	7	recently	recently	RB
cord-006229-7yoilsho	2119	8	identified	identify	VBN
cord-006229-7yoilsho	2119	9	as	as	IN
cord-006229-7yoilsho	2119	10	an	an	DT
cord-006229-7yoilsho	2119	11	emerging	emerge	VBG
cord-006229-7yoilsho	2119	12	biomarker	biomarker	NN
cord-006229-7yoilsho	2119	13	for	for	IN
cord-006229-7yoilsho	2119	14	stroke	stroke	NN
cord-006229-7yoilsho	2119	15	,	,	,
cord-006229-7yoilsho	2119	16	myocardial	myocardial	JJ
cord-006229-7yoilsho	2119	17	infarction	infarction	NN
cord-006229-7yoilsho	2119	18	,	,	,
cord-006229-7yoilsho	2119	19	and	and	CC
cord-006229-7yoilsho	2119	20	heart	heart	NN
cord-006229-7yoilsho	2119	21	failure	failure	NN
cord-006229-7yoilsho	2119	22	in	in	IN
cord-006229-7yoilsho	2119	23	clinical	clinical	JJ
cord-006229-7yoilsho	2119	24	and	and	CC
cord-006229-7yoilsho	2119	25	epidemiological	epidemiological	JJ
cord-006229-7yoilsho	2119	26	studies	study	NNS
cord-006229-7yoilsho	2119	27	.	.	.
cord-006229-7yoilsho	2120	1	hArg	hArg	NNP
cord-006229-7yoilsho	2120	2	competes	compete	NNS
cord-006229-7yoilsho	2120	3	with	with	IN
cord-006229-7yoilsho	2120	4	arginine	arginine	NN
cord-006229-7yoilsho	2120	5	as	as	IN
cord-006229-7yoilsho	2120	6	a	a	DT
cord-006229-7yoilsho	2120	7	substrate	substrate	NN
cord-006229-7yoilsho	2120	8	for	for	IN
cord-006229-7yoilsho	2120	9	nitric	nitric	NN
cord-006229-7yoilsho	2120	10	oxide	oxide	NN
cord-006229-7yoilsho	2120	11	(	(	-LRB-
cord-006229-7yoilsho	2120	12	NO	no	RB
cord-006229-7yoilsho	2120	13	)	)	-RRB-
cord-006229-7yoilsho	2121	1	synthase	synthase	NN
cord-006229-7yoilsho	2121	2	and	and	CC
cord-006229-7yoilsho	2121	3	weakly	weakly	RB
cord-006229-7yoilsho	2121	4	inhibits	inhibit	VBZ
cord-006229-7yoilsho	2121	5	arginase	arginase	NN
cord-006229-7yoilsho	2121	6	.	.	.
cord-006229-7yoilsho	2122	1	Both	both	DT
cord-006229-7yoilsho	2122	2	mechanisms	mechanism	NNS
cord-006229-7yoilsho	2122	3	might	may	MD
cord-006229-7yoilsho	2122	4	lead	lead	VB
cord-006229-7yoilsho	2122	5	to	to	IN
cord-006229-7yoilsho	2122	6	increased	increase	VBN
cord-006229-7yoilsho	2122	7	NO	no	DT
cord-006229-7yoilsho	2122	8	formation	formation	NN
cord-006229-7yoilsho	2122	9	in	in	IN
cord-006229-7yoilsho	2122	10	vivo	vivo	NN
cord-006229-7yoilsho	2122	11	.	.	.
cord-006229-7yoilsho	2123	1	The	the	DT
cord-006229-7yoilsho	2123	2	aim	aim	NN
cord-006229-7yoilsho	2123	3	of	of	IN
cord-006229-7yoilsho	2123	4	this	this	DT
cord-006229-7yoilsho	2123	5	study	study	NN
cord-006229-7yoilsho	2123	6	was	be	VBD
cord-006229-7yoilsho	2123	7	to	to	TO
cord-006229-7yoilsho	2123	8	investigate	investigate	VB
cord-006229-7yoilsho	2123	9	whether	whether	IN
cord-006229-7yoilsho	2123	10	hArg	hArg	NNP
cord-006229-7yoilsho	2123	11	effects	effect	NNS
cord-006229-7yoilsho	2123	12	the	the	DT
cord-006229-7yoilsho	2123	13	development	development	NN
cord-006229-7yoilsho	2123	14	of	of	IN
cord-006229-7yoilsho	2123	15	atherosclerosis	atherosclerosis	NN
cord-006229-7yoilsho	2123	16	as	as	IN
cord-006229-7yoilsho	2123	17	a	a	DT
cord-006229-7yoilsho	2123	18	potential	potential	JJ
cord-006229-7yoilsho	2123	19	underlying	underlie	VBG
cord-006229-7yoilsho	2123	20	mechanism	mechanism	NN
cord-006229-7yoilsho	2123	21	of	of	IN
cord-006229-7yoilsho	2123	22	cardiovascular	cardiovascular	JJ
cord-006229-7yoilsho	2123	23	diseases	disease	NNS
cord-006229-7yoilsho	2123	24	.	.	.
cord-006229-7yoilsho	2124	1	Methods	method	NNS
cord-006229-7yoilsho	2124	2	:	:	:
cord-006229-7yoilsho	2124	3	hArg	harg	VB
cord-006229-7yoilsho	2124	4	-	-	HYPH
cord-006229-7yoilsho	2124	5	deficient	deficient	JJ
cord-006229-7yoilsho	2124	6	AGAT	AGAT	NNP
cord-006229-7yoilsho	2124	7	-	-	HYPH
cord-006229-7yoilsho	2124	8	knockout	knockout	NN
cord-006229-7yoilsho	2124	9	(	(	-LRB-
cord-006229-7yoilsho	2124	10	AGAT	AGAT	NNP
cord-006229-7yoilsho	2124	11	-/-	-/-	NNP
cord-006229-7yoilsho	2124	12	)	)	-RRB-
cord-006229-7yoilsho	2124	13	and	and	CC
cord-006229-7yoilsho	2125	1	wildtype	wildtype	NNP
cord-006229-7yoilsho	2125	2	(	(	-LRB-
cord-006229-7yoilsho	2125	3	wt	wt	NN
cord-006229-7yoilsho	2125	4	)	)	-RRB-
cord-006229-7yoilsho	2125	5	mice	mouse	NNS
cord-006229-7yoilsho	2125	6	were	be	VBD
cord-006229-7yoilsho	2125	7	crossed	cross	VBN
cord-006229-7yoilsho	2125	8	with	with	IN
cord-006229-7yoilsho	2125	9	apolipoprotein	apolipoprotein	NN
cord-006229-7yoilsho	2125	10	E	E	NNP
cord-006229-7yoilsho	2125	11	(	(	-LRB-
cord-006229-7yoilsho	2125	12	ApoE	ApoE	NNS
cord-006229-7yoilsho	2125	13	)	)	-RRB-
cord-006229-7yoilsho	2125	14	deficient	deficient	JJ
cord-006229-7yoilsho	2125	15	mice	mouse	NNS
cord-006229-7yoilsho	2125	16	and	and	CC
cord-006229-7yoilsho	2125	17	fed	feed	VBN
cord-006229-7yoilsho	2125	18	with	with	IN
cord-006229-7yoilsho	2125	19	high	high	JJ
cord-006229-7yoilsho	2125	20	fat	fat	NN
cord-006229-7yoilsho	2125	21	diet	diet	NN
cord-006229-7yoilsho	2125	22	(	(	-LRB-
cord-006229-7yoilsho	2125	23	HFD	HFD	NNP
cord-006229-7yoilsho	2125	24	)	)	-RRB-
cord-006229-7yoilsho	2125	25	for	for	IN
cord-006229-7yoilsho	2125	26	three	three	CD
cord-006229-7yoilsho	2125	27	months	month	NNS
cord-006229-7yoilsho	2125	28	to	to	TO
cord-006229-7yoilsho	2125	29	induce	induce	VB
cord-006229-7yoilsho	2125	30	atherosclerosis	atherosclerosis	NN
cord-006229-7yoilsho	2125	31	.	.	.
cord-006229-7yoilsho	2126	1	hArg	harg	NN
cord-006229-7yoilsho	2126	2	plasma	plasma	NN
cord-006229-7yoilsho	2126	3	concentrations	concentration	NNS
cord-006229-7yoilsho	2126	4	were	be	VBD
cord-006229-7yoilsho	2126	5	determined	determine	VBN
cord-006229-7yoilsho	2126	6	using	use	VBG
cord-006229-7yoilsho	2126	7	mass	mass	NN
cord-006229-7yoilsho	2126	8	spectrometry	spectrometry	NN
cord-006229-7yoilsho	2126	9	.	.	.
cord-006229-7yoilsho	2127	1	En	en	IN
cord-006229-7yoilsho	2127	2	face	face	NN
cord-006229-7yoilsho	2127	3	preparation	preparation	NN
cord-006229-7yoilsho	2127	4	of	of	IN
cord-006229-7yoilsho	2127	5	aortae	aortae	NN
cord-006229-7yoilsho	2127	6	followed	follow	VBN
cord-006229-7yoilsho	2127	7	by	by	IN
cord-006229-7yoilsho	2127	8	red	red	JJ
cord-006229-7yoilsho	2127	9	oil	oil	NN
cord-006229-7yoilsho	2127	10	staining	staining	NN
cord-006229-7yoilsho	2127	11	of	of	IN
cord-006229-7yoilsho	2127	12	atherosclerotic	atherosclerotic	JJ
cord-006229-7yoilsho	2127	13	plaques	plaque	NNS
cord-006229-7yoilsho	2127	14	and	and	CC
cord-006229-7yoilsho	2127	15	quantitative	quantitative	JJ
cord-006229-7yoilsho	2127	16	evaluation	evaluation	NN
cord-006229-7yoilsho	2127	17	of	of	IN
cord-006229-7yoilsho	2127	18	plaque	plaque	NN
cord-006229-7yoilsho	2127	19	areas	area	NNS
cord-006229-7yoilsho	2127	20	was	be	VBD
cord-006229-7yoilsho	2127	21	performed	perform	VBN
cord-006229-7yoilsho	2127	22	for	for	IN
cord-006229-7yoilsho	2127	23	female	female	JJ
cord-006229-7yoilsho	2127	24	mice	mouse	NNS
cord-006229-7yoilsho	2127	25	.	.	.
cord-006229-7yoilsho	2128	1	Endothelial	endothelial	JJ
cord-006229-7yoilsho	2128	2	function	function	NN
cord-006229-7yoilsho	2128	3	of	of	IN
cord-006229-7yoilsho	2128	4	male	male	JJ
cord-006229-7yoilsho	2128	5	mice	mouse	NNS
cord-006229-7yoilsho	2128	6	was	be	VBD
cord-006229-7yoilsho	2128	7	tested	test	VBN
cord-006229-7yoilsho	2128	8	with	with	IN
cord-006229-7yoilsho	2128	9	acetylcholine	acetylcholine	NN
cord-006229-7yoilsho	2128	10	(	(	-LRB-
cord-006229-7yoilsho	2128	11	ACh	ACh	NNP
cord-006229-7yoilsho	2128	12	)	)	-RRB-
cord-006229-7yoilsho	2128	13	and	and	CC
cord-006229-7yoilsho	2128	14	nitroglycerin	nitroglycerin	NN
cord-006229-7yoilsho	2128	15	(	(	-LRB-
cord-006229-7yoilsho	2128	16	NTG	NTG	NNP
cord-006229-7yoilsho	2128	17	)	)	-RRB-
cord-006229-7yoilsho	2128	18	after	after	IN
cord-006229-7yoilsho	2128	19	contraction	contraction	NN
cord-006229-7yoilsho	2128	20	with	with	IN
cord-006229-7yoilsho	2128	21	prostaglandin	prostaglandin	NN
cord-006229-7yoilsho	2128	22	F2α	f2α	NN
cord-006229-7yoilsho	2128	23	.	.	.
cord-006229-7yoilsho	2129	1	Background	background	NN
cord-006229-7yoilsho	2129	2	:	:	:
cord-006229-7yoilsho	2130	1	The	the	DT
cord-006229-7yoilsho	2130	2	direct	direct	JJ
cord-006229-7yoilsho	2130	3	oral	oral	JJ
cord-006229-7yoilsho	2130	4	thrombin	thrombin	NN
cord-006229-7yoilsho	2130	5	inhibitor	inhibitor	NN
cord-006229-7yoilsho	2130	6	dabigatran	dabigatran	NNP
cord-006229-7yoilsho	2130	7	etexilate	etexilate	NNP
cord-006229-7yoilsho	2130	8	(	(	-LRB-
cord-006229-7yoilsho	2130	9	dabigatran	dabigatran	NNP
cord-006229-7yoilsho	2130	10	)	)	-RRB-
cord-006229-7yoilsho	2130	11	is	be	VBZ
cord-006229-7yoilsho	2130	12	used	use	VBN
cord-006229-7yoilsho	2130	13	for	for	IN
cord-006229-7yoilsho	2130	14	the	the	DT
cord-006229-7yoilsho	2130	15	prevention	prevention	NN
cord-006229-7yoilsho	2130	16	and	and	CC
cord-006229-7yoilsho	2130	17	treatment	treatment	NN
cord-006229-7yoilsho	2130	18	of	of	IN
cord-006229-7yoilsho	2130	19	venous	venous	JJ
cord-006229-7yoilsho	2130	20	thromboembolism	thromboembolism	NN
cord-006229-7yoilsho	2130	21	.	.	.
cord-006229-7yoilsho	2131	1	Obese	obese	JJ
cord-006229-7yoilsho	2131	2	patients	patient	NNS
cord-006229-7yoilsho	2131	3	as	as	RB
cord-006229-7yoilsho	2131	4	well	well	RB
cord-006229-7yoilsho	2131	5	as	as	IN
cord-006229-7yoilsho	2131	6	patients	patient	NNS
cord-006229-7yoilsho	2131	7	with	with	IN
cord-006229-7yoilsho	2131	8	type	type	NN
cord-006229-7yoilsho	2131	9	2	2	CD
cord-006229-7yoilsho	2131	10	diabetes	diabetes	NN
cord-006229-7yoilsho	2131	11	mellitus	mellitus	NN
cord-006229-7yoilsho	2131	12	(	(	-LRB-
cord-006229-7yoilsho	2131	13	T2DM	T2DM	NNP
cord-006229-7yoilsho	2131	14	)	)	-RRB-
cord-006229-7yoilsho	2131	15	have	have	VB
cord-006229-7yoilsho	2131	16	an	an	DT
cord-006229-7yoilsho	2131	17	increased	increase	VBN
cord-006229-7yoilsho	2131	18	risk	risk	NN
cord-006229-7yoilsho	2131	19	for	for	IN
cord-006229-7yoilsho	2131	20	thrombotic	thrombotic	JJ
cord-006229-7yoilsho	2131	21	disease	disease	NN
cord-006229-7yoilsho	2131	22	and	and	CC
cord-006229-7yoilsho	2131	23	show	show	VB
cord-006229-7yoilsho	2131	24	enhanced	enhance	VBN
cord-006229-7yoilsho	2131	25	thrombin	thrombin	JJ
cord-006229-7yoilsho	2131	26	generation	generation	NN
cord-006229-7yoilsho	2131	27	.	.	.
cord-006229-7yoilsho	2132	1	Besides	besides	IN
cord-006229-7yoilsho	2132	2	its	-PRON-	PRP$
cord-006229-7yoilsho	2132	3	role	role	NN
cord-006229-7yoilsho	2132	4	in	in	IN
cord-006229-7yoilsho	2132	5	blood	blood	NN
cord-006229-7yoilsho	2132	6	coagulation	coagulation	NN
cord-006229-7yoilsho	2132	7	,	,	,
cord-006229-7yoilsho	2132	8	thrombin	thrombin	NN
cord-006229-7yoilsho	2132	9	is	be	VBZ
cord-006229-7yoilsho	2132	10	known	know	VBN
cord-006229-7yoilsho	2132	11	to	to	TO
cord-006229-7yoilsho	2132	12	be	be	VB
cord-006229-7yoilsho	2132	13	involved	involve	VBN
cord-006229-7yoilsho	2132	14	in	in	IN
cord-006229-7yoilsho	2132	15	many	many	JJ
cord-006229-7yoilsho	2132	16	pro	pro	JJ
cord-006229-7yoilsho	2132	17	-	-	JJ
cord-006229-7yoilsho	2132	18	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	2132	19	processes	process	NNS
cord-006229-7yoilsho	2132	20	.	.	.
cord-006229-7yoilsho	2133	1	In	in	IN
cord-006229-7yoilsho	2133	2	obesity	obesity	NN
cord-006229-7yoilsho	2133	3	,	,	,
cord-006229-7yoilsho	2133	4	adipose	adipose	JJ
cord-006229-7yoilsho	2133	5	tissue	tissue	NN
cord-006229-7yoilsho	2134	1	(	(	-LRB-
cord-006229-7yoilsho	2134	2	AT	at	IN
cord-006229-7yoilsho	2134	3	)	)	-RRB-
cord-006229-7yoilsho	2134	4	inflammation	inflammation	NN
cord-006229-7yoilsho	2134	5	plays	play	VBZ
cord-006229-7yoilsho	2134	6	a	a	DT
cord-006229-7yoilsho	2134	7	crucial	crucial	JJ
cord-006229-7yoilsho	2134	8	role	role	NN
cord-006229-7yoilsho	2134	9	in	in	IN
cord-006229-7yoilsho	2134	10	the	the	DT
cord-006229-7yoilsho	2134	11	development	development	NN
cord-006229-7yoilsho	2134	12	of	of	IN
cord-006229-7yoilsho	2134	13	insulin	insulin	NN
cord-006229-7yoilsho	2134	14	resistance	resistance	NN
cord-006229-7yoilsho	2134	15	and	and	CC
cord-006229-7yoilsho	2134	16	T2DM	T2DM	NNP
cord-006229-7yoilsho	2134	17	and	and	CC
cord-006229-7yoilsho	2134	18	contributes	contribute	VBZ
cord-006229-7yoilsho	2134	19	to	to	IN
cord-006229-7yoilsho	2134	20	atherosclerosis	atherosclerosis	NN
cord-006229-7yoilsho	2134	21	development	development	NN
cord-006229-7yoilsho	2134	22	.	.	.
cord-006229-7yoilsho	2135	1	The	the	DT
cord-006229-7yoilsho	2135	2	aim	aim	NN
cord-006229-7yoilsho	2135	3	of	of	IN
cord-006229-7yoilsho	2135	4	the	the	DT
cord-006229-7yoilsho	2135	5	present	present	JJ
cord-006229-7yoilsho	2135	6	study	study	NN
cord-006229-7yoilsho	2135	7	was	be	VBD
cord-006229-7yoilsho	2135	8	to	to	TO
cord-006229-7yoilsho	2135	9	analyse	analyse	VB
cord-006229-7yoilsho	2135	10	the	the	DT
cord-006229-7yoilsho	2135	11	effects	effect	NNS
cord-006229-7yoilsho	2135	12	of	of	IN
cord-006229-7yoilsho	2135	13	dabigatran	dabigatran	NN
cord-006229-7yoilsho	2135	14	on	on	IN
cord-006229-7yoilsho	2135	15	AT	at	IN
cord-006229-7yoilsho	2135	16	inflammation	inflammation	NN
cord-006229-7yoilsho	2135	17	in	in	IN
cord-006229-7yoilsho	2135	18	a	a	DT
cord-006229-7yoilsho	2135	19	mouse	mouse	NN
cord-006229-7yoilsho	2135	20	model	model	NN
cord-006229-7yoilsho	2135	21	of	of	IN
cord-006229-7yoilsho	2135	22	diet	diet	NN
cord-006229-7yoilsho	2135	23	-	-	HYPH
cord-006229-7yoilsho	2135	24	induced	induce	VBN
cord-006229-7yoilsho	2135	25	obesity	obesity	NN
cord-006229-7yoilsho	2135	26	in	in	IN
cord-006229-7yoilsho	2135	27	the	the	DT
cord-006229-7yoilsho	2135	28	context	context	NN
cord-006229-7yoilsho	2135	29	of	of	IN
cord-006229-7yoilsho	2135	30	accelerated	accelerated	JJ
cord-006229-7yoilsho	2135	31	atherosclerosis	atherosclerosis	NN
cord-006229-7yoilsho	2135	32	.	.	.
cord-006229-7yoilsho	2136	1	Methods	method	NNS
cord-006229-7yoilsho	2136	2	:	:	:
cord-006229-7yoilsho	2136	3	10-week	10-week	JJ
cord-006229-7yoilsho	2136	4	-	-	HYPH
cord-006229-7yoilsho	2136	5	old	old	JJ
cord-006229-7yoilsho	2136	6	female	female	JJ
cord-006229-7yoilsho	2136	7	low	low	JJ
cord-006229-7yoilsho	2136	8	-	-	HYPH
cord-006229-7yoilsho	2136	9	density	density	NN
cord-006229-7yoilsho	2136	10	lipoprotein	lipoprotein	NN
cord-006229-7yoilsho	2136	11	receptor	receptor	NN
cord-006229-7yoilsho	2136	12	-	-	HYPH
cord-006229-7yoilsho	2136	13	deficient	deficient	JJ
cord-006229-7yoilsho	2136	14	(	(	-LRB-
cord-006229-7yoilsho	2136	15	Lldr	Lldr	NNP
cord-006229-7yoilsho	2136	16	-/-	-/-	NNP
cord-006229-7yoilsho	2136	17	)	)	-RRB-
cord-006229-7yoilsho	2137	1	mice	mouse	NNS
cord-006229-7yoilsho	2137	2	were	be	VBD
cord-006229-7yoilsho	2137	3	fed	feed	VBN
cord-006229-7yoilsho	2137	4	a	a	DT
cord-006229-7yoilsho	2137	5	high	high	JJ
cord-006229-7yoilsho	2137	6	-	-	HYPH
cord-006229-7yoilsho	2137	7	fat	fat	NN
cord-006229-7yoilsho	2137	8	diet	diet	NN
cord-006229-7yoilsho	2137	9	containing	contain	VBG
cord-006229-7yoilsho	2137	10	5	5	CD
cord-006229-7yoilsho	2137	11	mg	mg	NNP
cord-006229-7yoilsho	2137	12	/	/	SYM
cord-006229-7yoilsho	2137	13	g	g	NN
cord-006229-7yoilsho	2137	14	dabigatran	dabigatran	NN
cord-006229-7yoilsho	2137	15	or	or	CC
cord-006229-7yoilsho	2137	16	respective	respective	JJ
cord-006229-7yoilsho	2137	17	placebo	placebo	NN
cord-006229-7yoilsho	2137	18	for	for	IN
cord-006229-7yoilsho	2137	19	20	20	CD
cord-006229-7yoilsho	2137	20	weeks	week	NNS
cord-006229-7yoilsho	2137	21	.	.	.
cord-006229-7yoilsho	2138	1	Results	result	NNS
cord-006229-7yoilsho	2138	2	:	:	:
cord-006229-7yoilsho	2139	1	Analysis	analysis	NN
cord-006229-7yoilsho	2139	2	of	of	IN
cord-006229-7yoilsho	2139	3	visceral	visceral	JJ
cord-006229-7yoilsho	2139	4	AT	AT	NNP
cord-006229-7yoilsho	2139	5	revealed	reveal	VBD
cord-006229-7yoilsho	2139	6	a	a	DT
cord-006229-7yoilsho	2139	7	significant	significant	JJ
cord-006229-7yoilsho	2139	8	increase	increase	NN
cord-006229-7yoilsho	2139	9	in	in	IN
cord-006229-7yoilsho	2139	10	adipocyte	adipocyte	JJ
cord-006229-7yoilsho	2139	11	size	size	NN
cord-006229-7yoilsho	2139	12	in	in	IN
cord-006229-7yoilsho	2139	13	dabigatran	dabigatran	NN
cord-006229-7yoilsho	2139	14	-	-	HYPH
cord-006229-7yoilsho	2139	15	treated	treat	VBN
cord-006229-7yoilsho	2139	16	mice	mouse	NNS
cord-006229-7yoilsho	2139	17	,	,	,
cord-006229-7yoilsho	2139	18	although	although	IN
cord-006229-7yoilsho	2139	19	body	body	NN
cord-006229-7yoilsho	2139	20	weight	weight	NN
cord-006229-7yoilsho	2139	21	,	,	,
cord-006229-7yoilsho	2139	22	fat	fat	JJ
cord-006229-7yoilsho	2139	23	mass	mass	NN
cord-006229-7yoilsho	2139	24	,	,	,
cord-006229-7yoilsho	2139	25	glucose	glucose	NN
cord-006229-7yoilsho	2139	26	tolerance	tolerance	NN
cord-006229-7yoilsho	2139	27	,	,	,
cord-006229-7yoilsho	2139	28	and	and	CC
cord-006229-7yoilsho	2139	29	insulin	insulin	NN
cord-006229-7yoilsho	2139	30	resistance	resistance	NN
cord-006229-7yoilsho	2139	31	were	be	VBD
cord-006229-7yoilsho	2139	32	unchanged	unchanged	JJ
cord-006229-7yoilsho	2139	33	between	between	IN
cord-006229-7yoilsho	2139	34	groups	group	NNS
cord-006229-7yoilsho	2139	35	.	.	.
cord-006229-7yoilsho	2140	1	This	this	DT
cord-006229-7yoilsho	2140	2	effects	effect	NNS
cord-006229-7yoilsho	2140	3	seemed	seem	VBD
cord-006229-7yoilsho	2140	4	to	to	TO
cord-006229-7yoilsho	2140	5	be	be	VB
cord-006229-7yoilsho	2140	6	directly	directly	RB
cord-006229-7yoilsho	2140	7	mediated	mediate	VBN
cord-006229-7yoilsho	2140	8	by	by	IN
cord-006229-7yoilsho	2140	9	thrombin	thrombin	NN
cord-006229-7yoilsho	2140	10	,	,	,
cord-006229-7yoilsho	2140	11	as	as	IN
cord-006229-7yoilsho	2140	12	treatment	treatment	NN
cord-006229-7yoilsho	2140	13	with	with	IN
cord-006229-7yoilsho	2140	14	another	another	DT
cord-006229-7yoilsho	2140	15	thrombin	thrombin	JJ
cord-006229-7yoilsho	2140	16	inhibitor	inhibitor	NN
cord-006229-7yoilsho	2140	17	(	(	-LRB-
cord-006229-7yoilsho	2140	18	argatroban	argatroban	NNP
cord-006229-7yoilsho	2140	19	)	)	-RRB-
cord-006229-7yoilsho	2140	20	also	also	RB
cord-006229-7yoilsho	2140	21	resulted	result	VBD
cord-006229-7yoilsho	2140	22	in	in	IN
cord-006229-7yoilsho	2140	23	the	the	DT
cord-006229-7yoilsho	2140	24	development	development	NN
cord-006229-7yoilsho	2140	25	of	of	IN
cord-006229-7yoilsho	2140	26	adipocyte	adipocyte	NN
cord-006229-7yoilsho	2140	27	hypertrophy	hypertrophy	NN
cord-006229-7yoilsho	2140	28	.	.	.
cord-006229-7yoilsho	2141	1	Accordingly	accordingly	RB
cord-006229-7yoilsho	2141	2	,	,	,
cord-006229-7yoilsho	2141	3	in	in	IN
cord-006229-7yoilsho	2141	4	vitro	vitro	FW
cord-006229-7yoilsho	2141	5	studies	study	NNS
cord-006229-7yoilsho	2141	6	in	in	IN
cord-006229-7yoilsho	2141	7	3T3-L1	3t3-l1	CD
cord-006229-7yoilsho	2141	8	cells	cell	NNS
cord-006229-7yoilsho	2141	9	revealed	reveal	VBD
cord-006229-7yoilsho	2141	10	an	an	DT
cord-006229-7yoilsho	2141	11	inhibitory	inhibitory	JJ
cord-006229-7yoilsho	2141	12	effect	effect	NN
cord-006229-7yoilsho	2141	13	of	of	IN
cord-006229-7yoilsho	2141	14	thrombin	thrombin	NN
cord-006229-7yoilsho	2141	15	on	on	IN
cord-006229-7yoilsho	2141	16	lipid	lipid	NN
cord-006229-7yoilsho	2141	17	accumulation	accumulation	NN
cord-006229-7yoilsho	2141	18	in	in	IN
cord-006229-7yoilsho	2141	19	adipocytes	adipocyte	NNS
cord-006229-7yoilsho	2141	20	.	.	.
cord-006229-7yoilsho	2142	1	The	the	DT
cord-006229-7yoilsho	2142	2	amount	amount	NN
cord-006229-7yoilsho	2142	3	of	of	IN
cord-006229-7yoilsho	2142	4	pro	pro	JJ
cord-006229-7yoilsho	2142	5	-	-	JJ
cord-006229-7yoilsho	2142	6	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	2142	7	CD11c	CD11c	NNP
cord-006229-7yoilsho	2142	8	-	-	HYPH
cord-006229-7yoilsho	2142	9	positive	positive	JJ
cord-006229-7yoilsho	2142	10	macrophages	macrophage	NNS
cord-006229-7yoilsho	2142	11	(	(	-LRB-
cord-006229-7yoilsho	2142	12	ATMs	atm	NNS
cord-006229-7yoilsho	2142	13	)	)	-RRB-
cord-006229-7yoilsho	2142	14	in	in	IN
cord-006229-7yoilsho	2142	15	visceral	visceral	JJ
cord-006229-7yoilsho	2142	16	adipose	adipose	JJ
cord-006229-7yoilsho	2142	17	tissue	tissue	NN
cord-006229-7yoilsho	2142	18	was	be	VBD
cord-006229-7yoilsho	2142	19	significantly	significantly	RB
cord-006229-7yoilsho	2142	20	reduced	reduce	VBN
cord-006229-7yoilsho	2142	21	,	,	,
cord-006229-7yoilsho	2142	22	and	and	CC
cord-006229-7yoilsho	2142	23	the	the	DT
cord-006229-7yoilsho	2142	24	secretion	secretion	NN
cord-006229-7yoilsho	2142	25	of	of	IN
cord-006229-7yoilsho	2142	26	pro	pro	JJ
cord-006229-7yoilsho	2142	27	-	-	JJ
cord-006229-7yoilsho	2142	28	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	2142	29	IL-6	IL-6	NNP
cord-006229-7yoilsho	2142	30	from	from	IN
cord-006229-7yoilsho	2142	31	visceral	visceral	JJ
cord-006229-7yoilsho	2142	32	AT	AT	NNP
cord-006229-7yoilsho	2142	33	was	be	VBD
cord-006229-7yoilsho	2142	34	significantly	significantly	RB
cord-006229-7yoilsho	2142	35	lower	low	JJR
cord-006229-7yoilsho	2142	36	in	in	IN
cord-006229-7yoilsho	2142	37	dabigatran	dabigatran	NN
cord-006229-7yoilsho	2142	38	-	-	HYPH
cord-006229-7yoilsho	2142	39	treated	treat	VBN
cord-006229-7yoilsho	2142	40	animals	animal	NNS
cord-006229-7yoilsho	2142	41	.	.	.
cord-006229-7yoilsho	2143	1	In	in	IN
cord-006229-7yoilsho	2143	2	vitro	vitro	FW
cord-006229-7yoilsho	2143	3	studies	study	NNS
cord-006229-7yoilsho	2143	4	using	use	VBG
cord-006229-7yoilsho	2143	5	3T3	3t3	CD
cord-006229-7yoilsho	2143	6	L1	L1	NNP
cord-006229-7yoilsho	2143	7	cells	cell	NNS
cord-006229-7yoilsho	2143	8	and	and	CC
cord-006229-7yoilsho	2143	9	primary	primary	JJ
cord-006229-7yoilsho	2143	10	bone	bone	NN
cord-006229-7yoilsho	2143	11	marrow	marrow	NN
cord-006229-7yoilsho	2143	12	-	-	HYPH
cord-006229-7yoilsho	2143	13	derived	derive	VBN
cord-006229-7yoilsho	2143	14	macrophages	macrophage	NNS
cord-006229-7yoilsho	2143	15	revealed	reveal	VBD
cord-006229-7yoilsho	2143	16	that	that	IN
cord-006229-7yoilsho	2143	17	the	the	DT
cord-006229-7yoilsho	2143	18	changes	change	NNS
cord-006229-7yoilsho	2143	19	in	in	IN
cord-006229-7yoilsho	2143	20	macrophage	macrophage	NN
cord-006229-7yoilsho	2143	21	polarization	polarization	NN
cord-006229-7yoilsho	2143	22	were	be	VBD
cord-006229-7yoilsho	2143	23	not	not	RB
cord-006229-7yoilsho	2143	24	directly	directly	RB
cord-006229-7yoilsho	2143	25	mediated	mediate	VBN
cord-006229-7yoilsho	2143	26	by	by	IN
cord-006229-7yoilsho	2143	27	thrombin	thrombin	NN
cord-006229-7yoilsho	2143	28	,	,	,
cord-006229-7yoilsho	2143	29	but	but	CC
cord-006229-7yoilsho	2143	30	indirectly	indirectly	RB
cord-006229-7yoilsho	2143	31	by	by	IN
cord-006229-7yoilsho	2143	32	a	a	DT
cord-006229-7yoilsho	2143	33	change	change	NN
cord-006229-7yoilsho	2143	34	in	in	IN
cord-006229-7yoilsho	2143	35	the	the	DT
cord-006229-7yoilsho	2143	36	secretion	secretion	NN
cord-006229-7yoilsho	2143	37	profile	profile	NN
cord-006229-7yoilsho	2143	38	of	of	IN
cord-006229-7yoilsho	2143	39	adipocytes	adipocyte	NNS
cord-006229-7yoilsho	2143	40	.	.	.
cord-006229-7yoilsho	2144	1	A	a	DT
cord-006229-7yoilsho	2144	2	similar	similar	JJ
cord-006229-7yoilsho	2144	3	reduction	reduction	NN
cord-006229-7yoilsho	2144	4	in	in	IN
cord-006229-7yoilsho	2144	5	proinflammatory	proinflammatory	JJ
cord-006229-7yoilsho	2144	6	macrophages	macrophage	NNS
cord-006229-7yoilsho	2144	7	as	as	IN
cord-006229-7yoilsho	2144	8	detected	detect	VBN
cord-006229-7yoilsho	2144	9	in	in	IN
cord-006229-7yoilsho	2144	10	AT	AT	NNP
cord-006229-7yoilsho	2144	11	could	could	MD
cord-006229-7yoilsho	2144	12	also	also	RB
cord-006229-7yoilsho	2144	13	be	be	VB
cord-006229-7yoilsho	2144	14	observed	observe	VBN
cord-006229-7yoilsho	2144	15	in	in	IN
cord-006229-7yoilsho	2144	16	the	the	DT
cord-006229-7yoilsho	2144	17	aortic	aortic	JJ
cord-006229-7yoilsho	2144	18	wall	wall	NN
cord-006229-7yoilsho	2144	19	of	of	IN
cord-006229-7yoilsho	2144	20	dabigatran	dabigatran	NN
cord-006229-7yoilsho	2144	21	-	-	HYPH
cord-006229-7yoilsho	2144	22	treated	treat	VBN
cord-006229-7yoilsho	2144	23	mice	mouse	NNS
cord-006229-7yoilsho	2144	24	.	.	.
cord-006229-7yoilsho	2145	1	Conclusions	conclusion	NNS
cord-006229-7yoilsho	2145	2	:	:	:
cord-006229-7yoilsho	2146	1	The	the	DT
cord-006229-7yoilsho	2146	2	direct	direct	JJ
cord-006229-7yoilsho	2146	3	thrombin	thrombin	NN
cord-006229-7yoilsho	2146	4	inhibitor	inhibitor	NN
cord-006229-7yoilsho	2146	5	dabigatran	dabigatran	NN
cord-006229-7yoilsho	2146	6	inhibits	inhibit	VBZ
cord-006229-7yoilsho	2146	7	AT	at	IN
cord-006229-7yoilsho	2146	8	inflammation	inflammation	NN
cord-006229-7yoilsho	2146	9	and	and	CC
cord-006229-7yoilsho	2146	10	the	the	DT
cord-006229-7yoilsho	2146	11	accumulation	accumulation	NN
cord-006229-7yoilsho	2146	12	of	of	IN
cord-006229-7yoilsho	2146	13	pro	pro	JJ
cord-006229-7yoilsho	2146	14	-	-	JJ
cord-006229-7yoilsho	2146	15	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	2146	16	macrophages	macrophage	NNS
cord-006229-7yoilsho	2146	17	in	in	IN
cord-006229-7yoilsho	2146	18	VAT	vat	NN
cord-006229-7yoilsho	2146	19	but	but	CC
cord-006229-7yoilsho	2146	20	also	also	RB
cord-006229-7yoilsho	2146	21	the	the	DT
cord-006229-7yoilsho	2146	22	aortic	aortic	JJ
cord-006229-7yoilsho	2146	23	wall	wall	NN
cord-006229-7yoilsho	2146	24	of	of	IN
cord-006229-7yoilsho	2146	25	Ldlr	Ldlr	NNP
cord-006229-7yoilsho	2146	26	-/mice	-/mice	ADD
cord-006229-7yoilsho	2146	27	.	.	.
cord-006229-7yoilsho	2147	1	These	these	DT
cord-006229-7yoilsho	2147	2	anti	anti	JJ
cord-006229-7yoilsho	2147	3	-	-	JJ
cord-006229-7yoilsho	2147	4	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	2147	5	effects	effect	NNS
cord-006229-7yoilsho	2147	6	of	of	IN
cord-006229-7yoilsho	2147	7	dabigatran	dabigatran	NN
cord-006229-7yoilsho	2147	8	might	may	MD
cord-006229-7yoilsho	2147	9	contribute	contribute	VB
cord-006229-7yoilsho	2147	10	to	to	IN
cord-006229-7yoilsho	2147	11	the	the	DT
cord-006229-7yoilsho	2147	12	known	know	VBN
cord-006229-7yoilsho	2147	13	atheroprotective	atheroprotective	JJ
cord-006229-7yoilsho	2147	14	effects	effect	NNS
cord-006229-7yoilsho	2147	15	of	of	IN
cord-006229-7yoilsho	2147	16	dabigatran	dabigatran	NN
cord-006229-7yoilsho	2147	17	.	.	.
cord-006229-7yoilsho	2148	1	Background	background	NN
cord-006229-7yoilsho	2148	2	:	:	:
cord-006229-7yoilsho	2149	1	Sarco	Sarco	NNP
cord-006229-7yoilsho	2149	2	/	/	SYM
cord-006229-7yoilsho	2149	3	endoplasmic	endoplasmic	NN
cord-006229-7yoilsho	2149	4	reticulum	reticulum	NN
cord-006229-7yoilsho	2150	1	Ca	ca	RB
cord-006229-7yoilsho	2150	2	2	2	CD
cord-006229-7yoilsho	2151	1	+	+	CC
cord-006229-7yoilsho	2152	1	-ATPase	-ATPase	NNP
cord-006229-7yoilsho	2153	1	(	(	-LRB-
cord-006229-7yoilsho	2153	2	SERCA2a	serca2a	NN
cord-006229-7yoilsho	2153	3	)	)	-RRB-
cord-006229-7yoilsho	2153	4	and	and	CC
cord-006229-7yoilsho	2153	5	its	-PRON-	PRP$
cord-006229-7yoilsho	2153	6	inhibitor	inhibitor	NN
cord-006229-7yoilsho	2153	7	phospholamban	phospholamban	NNP
cord-006229-7yoilsho	2153	8	(	(	-LRB-
cord-006229-7yoilsho	2153	9	PLN	PLN	NNP
cord-006229-7yoilsho	2153	10	)	)	-RRB-
cord-006229-7yoilsho	2153	11	are	be	VBP
cord-006229-7yoilsho	2153	12	critical	critical	JJ
cord-006229-7yoilsho	2153	13	determinants	determinant	NNS
cord-006229-7yoilsho	2153	14	of	of	IN
cord-006229-7yoilsho	2153	15	cardiomyocyte	cardiomyocyte	NNP
cord-006229-7yoilsho	2153	16	calcium	calcium	NN
cord-006229-7yoilsho	2153	17	cycling	cycling	NN
cord-006229-7yoilsho	2153	18	and	and	CC
cord-006229-7yoilsho	2153	19	hence	hence	RB
cord-006229-7yoilsho	2153	20	,	,	,
cord-006229-7yoilsho	2153	21	cardiac	cardiac	JJ
cord-006229-7yoilsho	2153	22	contractility	contractility	NN
cord-006229-7yoilsho	2153	23	.	.	.
cord-006229-7yoilsho	2154	1	PLN	PLN	NNP
cord-006229-7yoilsho	2154	2	exists	exist	VBZ
cord-006229-7yoilsho	2154	3	in	in	IN
cord-006229-7yoilsho	2154	4	an	an	DT
cord-006229-7yoilsho	2154	5	equilibrium	equilibrium	NN
cord-006229-7yoilsho	2154	6	between	between	IN
cord-006229-7yoilsho	2154	7	mono	mono	NN
cord-006229-7yoilsho	2154	8	-	-	HYPH
cord-006229-7yoilsho	2154	9	and	and	CC
cord-006229-7yoilsho	2154	10	pentamers	pentamer	NNS
cord-006229-7yoilsho	2154	11	.	.	.
cord-006229-7yoilsho	2155	1	While	while	IN
cord-006229-7yoilsho	2155	2	monomeric	monomeric	JJ
cord-006229-7yoilsho	2155	3	PLN	PLN	NNP
cord-006229-7yoilsho	2155	4	has	have	VBZ
cord-006229-7yoilsho	2155	5	been	be	VBN
cord-006229-7yoilsho	2155	6	implicated	implicate	VBN
cord-006229-7yoilsho	2155	7	in	in	IN
cord-006229-7yoilsho	2155	8	direct	direct	JJ
cord-006229-7yoilsho	2155	9	SERCA2a	serca2a	NN
cord-006229-7yoilsho	2155	10	inhibition	inhibition	NN
cord-006229-7yoilsho	2155	11	,	,	,
cord-006229-7yoilsho	2155	12	a	a	DT
cord-006229-7yoilsho	2155	13	functional	functional	JJ
cord-006229-7yoilsho	2155	14	role	role	NN
cord-006229-7yoilsho	2155	15	for	for	IN
cord-006229-7yoilsho	2155	16	the	the	DT
cord-006229-7yoilsho	2155	17	pentamers	pentamer	NNS
cord-006229-7yoilsho	2155	18	remains	remain	VBZ
cord-006229-7yoilsho	2155	19	ambiguous	ambiguous	JJ
cord-006229-7yoilsho	2155	20	.	.	.
cord-006229-7yoilsho	2156	1	Recently	recently	RB
cord-006229-7yoilsho	2156	2	it	-PRON-	PRP
cord-006229-7yoilsho	2156	3	has	have	VBZ
cord-006229-7yoilsho	2156	4	been	be	VBN
cord-006229-7yoilsho	2156	5	shown	show	VBN
cord-006229-7yoilsho	2156	6	that	that	IN
cord-006229-7yoilsho	2156	7	PLN	PLN	NNP
cord-006229-7yoilsho	2156	8	pentamers	pentamer	NNS
cord-006229-7yoilsho	2156	9	modulate	modulate	VBP
cord-006229-7yoilsho	2156	10	PKA	PKA	NNP
cord-006229-7yoilsho	2156	11	-	-	HYPH
cord-006229-7yoilsho	2156	12	dependent	dependent	JJ
cord-006229-7yoilsho	2156	13	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	2156	14	of	of	IN
cord-006229-7yoilsho	2156	15	PLN	PLN	NNP
cord-006229-7yoilsho	2156	16	monomers	monomer	NNS
cord-006229-7yoilsho	2156	17	in	in	IN
cord-006229-7yoilsho	2156	18	vitro	vitro	FW
cord-006229-7yoilsho	2156	19	.	.	.
cord-006229-7yoilsho	2157	1	1	1	LS
cord-006229-7yoilsho	2158	1	Using	use	VBG
cord-006229-7yoilsho	2158	2	transgenic	transgenic	JJ
cord-006229-7yoilsho	2158	3	mouse	mouse	NN
cord-006229-7yoilsho	2158	4	models	model	NNS
cord-006229-7yoilsho	2158	5	we	-PRON-	PRP
cord-006229-7yoilsho	2158	6	now	now	RB
cord-006229-7yoilsho	2158	7	investigated	investigate	VBD
cord-006229-7yoilsho	2158	8	the	the	DT
cord-006229-7yoilsho	2158	9	effects	effect	NNS
cord-006229-7yoilsho	2158	10	of	of	IN
cord-006229-7yoilsho	2158	11	PLN	PLN	NNP
cord-006229-7yoilsho	2158	12	pentamers	pentamer	NNS
cord-006229-7yoilsho	2158	13	on	on	IN
cord-006229-7yoilsho	2158	14	PLN	PLN	NNP
cord-006229-7yoilsho	2158	15	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	2158	16	,	,	,
cord-006229-7yoilsho	2158	17	myocyte	myocyte	NNP
cord-006229-7yoilsho	2159	1	Ca	ca	NN
cord-006229-7yoilsho	2159	2	2	2	CD
cord-006229-7yoilsho	2159	3	+	+	CC
cord-006229-7yoilsho	2159	4	cycling	cycling	NN
cord-006229-7yoilsho	2159	5	and	and	CC
cord-006229-7yoilsho	2159	6	contractility	contractility	NN
cord-006229-7yoilsho	2159	7	in	in	IN
cord-006229-7yoilsho	2159	8	cardiac	cardiac	JJ
cord-006229-7yoilsho	2159	9	myocytes	myocyte	NNS
cord-006229-7yoilsho	2159	10	.	.	.
cord-006229-7yoilsho	2160	1	Methods	method	NNS
cord-006229-7yoilsho	2160	2	:	:	:
cord-006229-7yoilsho	2161	1	Phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	2161	2	patterns	pattern	NNS
cord-006229-7yoilsho	2161	3	of	of	IN
cord-006229-7yoilsho	2161	4	PLN	PLN	NNP
cord-006229-7yoilsho	2161	5	were	be	VBD
cord-006229-7yoilsho	2161	6	analyzed	analyze	VBN
cord-006229-7yoilsho	2161	7	by	by	IN
cord-006229-7yoilsho	2161	8	Western	western	JJ
cord-006229-7yoilsho	2161	9	blot	blot	NN
cord-006229-7yoilsho	2161	10	using	use	VBG
cord-006229-7yoilsho	2161	11	phospho	phospho	NN
cord-006229-7yoilsho	2161	12	-	-	HYPH
cord-006229-7yoilsho	2161	13	specific	specific	JJ
cord-006229-7yoilsho	2161	14	antibodies	antibody	NNS
cord-006229-7yoilsho	2161	15	as	as	RB
cord-006229-7yoilsho	2161	16	well	well	RB
cord-006229-7yoilsho	2161	17	as	as	IN
cord-006229-7yoilsho	2161	18	phosphate	phosphate	NN
cord-006229-7yoilsho	2161	19	affinity	affinity	NN
cord-006229-7yoilsho	2161	20	SDS	sds	NN
cord-006229-7yoilsho	2161	21	-	-	HYPH
cord-006229-7yoilsho	2161	22	PAGE	PAGE	NNP
cord-006229-7yoilsho	2161	23	.	.	.
cord-006229-7yoilsho	2162	1	To	to	TO
cord-006229-7yoilsho	2162	2	assess	assess	VB
cord-006229-7yoilsho	2162	3	the	the	DT
cord-006229-7yoilsho	2162	4	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	2162	5	at	at	IN
cord-006229-7yoilsho	2162	6	baseline	baseline	NN
cord-006229-7yoilsho	2163	1	,	,	,
cord-006229-7yoilsho	2163	2	PLN	PLN	NNP
cord-006229-7yoilsho	2163	3	knockout	knockout	NN
cord-006229-7yoilsho	2163	4	(	(	-LRB-
cord-006229-7yoilsho	2163	5	PLN	PLN	NNP
cord-006229-7yoilsho	2163	6	-	-	HYPH
cord-006229-7yoilsho	2163	7	KO	KO	NNP
cord-006229-7yoilsho	2163	8	)	)	-RRB-
cord-006229-7yoilsho	2163	9	mice	mouse	NNS
cord-006229-7yoilsho	2163	10	expressing	express	VBG
cord-006229-7yoilsho	2163	11	either	either	CC
cord-006229-7yoilsho	2163	12	wild	wild	JJ
cord-006229-7yoilsho	2163	13	type	type	NN
cord-006229-7yoilsho	2163	14	PLN	PLN	NNP
cord-006229-7yoilsho	2163	15	(	(	-LRB-
cord-006229-7yoilsho	2163	16	TgPLN	TgPLN	NNP
cord-006229-7yoilsho	2163	17	)	)	-RRB-
cord-006229-7yoilsho	2163	18	or	or	CC
cord-006229-7yoilsho	2163	19	the	the	DT
cord-006229-7yoilsho	2163	20	solely	solely	RB
cord-006229-7yoilsho	2163	21	monomeric	monomeric	JJ
cord-006229-7yoilsho	2163	22	PLN	PLN	NNP
cord-006229-7yoilsho	2163	23	AFA	AFA	NNP
cord-006229-7yoilsho	2163	24	mutant	mutant	NN
cord-006229-7yoilsho	2163	25	(	(	-LRB-
cord-006229-7yoilsho	2163	26	TgAFA	TgAFA	NNP
cord-006229-7yoilsho	2163	27	)	)	-RRB-
cord-006229-7yoilsho	2163	28	transgene	transgene	NN
cord-006229-7yoilsho	2163	29	were	be	VBD
cord-006229-7yoilsho	2163	30	deeply	deeply	RB
cord-006229-7yoilsho	2163	31	anesthetized	anesthetize	VBN
cord-006229-7yoilsho	2163	32	,	,	,
cord-006229-7yoilsho	2163	33	whereas	whereas	IN
cord-006229-7yoilsho	2163	34	PLN	PLN	NNP
cord-006229-7yoilsho	2163	35	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	2163	36	by	by	IN
cord-006229-7yoilsho	2163	37	PKA	PKA	NNP
cord-006229-7yoilsho	2163	38	was	be	VBD
cord-006229-7yoilsho	2163	39	induced	induce	VBN
cord-006229-7yoilsho	2163	40	using	use	VBG
cord-006229-7yoilsho	2163	41	the	the	DT
cord-006229-7yoilsho	2163	42	betaadrenergic	betaadrenergic	JJ
cord-006229-7yoilsho	2163	43	agonist	agonist	NN
cord-006229-7yoilsho	2163	44	isoproterenol	isoproterenol	NNP
cord-006229-7yoilsho	2163	45	.	.	.
cord-006229-7yoilsho	2164	1	The	the	DT
cord-006229-7yoilsho	2164	2	consequences	consequence	NNS
cord-006229-7yoilsho	2164	3	on	on	IN
cord-006229-7yoilsho	2164	4	myocyte	myocyte	NNP
cord-006229-7yoilsho	2165	1	Ca	ca	NN
cord-006229-7yoilsho	2165	2	2	2	CD
cord-006229-7yoilsho	2165	3	+	+	SYM
cord-006229-7yoilsho	2165	4	kinetics	kinetic	NNS
cord-006229-7yoilsho	2165	5	were	be	VBD
cord-006229-7yoilsho	2165	6	measured	measure	VBN
cord-006229-7yoilsho	2165	7	in	in	IN
cord-006229-7yoilsho	2165	8	isolated	isolate	VBN
cord-006229-7yoilsho	2165	9	,	,	,
cord-006229-7yoilsho	2165	10	Fura2-loaded	Fura2-loaded	NNP
cord-006229-7yoilsho	2165	11	and	and	CC
cord-006229-7yoilsho	2165	12	electrically	electrically	RB
cord-006229-7yoilsho	2165	13	paced	paced	JJ
cord-006229-7yoilsho	2165	14	(	(	-LRB-
cord-006229-7yoilsho	2165	15	0.5Hz	0.5hz	CD
cord-006229-7yoilsho	2165	16	)	)	-RRB-
cord-006229-7yoilsho	2166	1	cardiomyocytes	cardiomyocyte	NNS
cord-006229-7yoilsho	2166	2	as	as	IN
cord-006229-7yoilsho	2166	3	the	the	DT
cord-006229-7yoilsho	2166	4	time	time	NN
cord-006229-7yoilsho	2166	5	to	to	IN
cord-006229-7yoilsho	2166	6	50	50	CD
cord-006229-7yoilsho	2166	7	%	%	NN
cord-006229-7yoilsho	2166	8	decay	decay	NN
cord-006229-7yoilsho	2166	9	of	of	IN
cord-006229-7yoilsho	2166	10	the	the	DT
cord-006229-7yoilsho	2166	11	Ca	Ca	NNP
cord-006229-7yoilsho	2166	12	2	2	CD
cord-006229-7yoilsho	2166	13	+	+	SYM
cord-006229-7yoilsho	2166	14	signal	signal	NN
cord-006229-7yoilsho	2166	15	(	(	-LRB-
cord-006229-7yoilsho	2166	16	T	T	NNP
cord-006229-7yoilsho	2166	17	50	50	CD
cord-006229-7yoilsho	2166	18	%	%	NN
cord-006229-7yoilsho	2166	19	)	)	-RRB-
cord-006229-7yoilsho	2166	20	.	.	.
cord-006229-7yoilsho	2167	1	The	the	DT
cord-006229-7yoilsho	2167	2	time	time	NN
cord-006229-7yoilsho	2167	3	to	to	IN
cord-006229-7yoilsho	2167	4	50	50	CD
cord-006229-7yoilsho	2167	5	%	%	NN
cord-006229-7yoilsho	2167	6	baseline	baseline	NN
cord-006229-7yoilsho	2167	7	of	of	IN
cord-006229-7yoilsho	2167	8	sarcomere	sarcomere	NN
cord-006229-7yoilsho	2167	9	length	length	NN
cord-006229-7yoilsho	2168	1	(	(	-LRB-
cord-006229-7yoilsho	2168	2	T	T	NNP
cord-006229-7yoilsho	2168	3	50	50	CD
cord-006229-7yoilsho	2168	4	%	%	NN
cord-006229-7yoilsho	2168	5	baseline	baseline	NN
cord-006229-7yoilsho	2168	6	)	)	-RRB-
cord-006229-7yoilsho	2168	7	characterized	characterize	VBD
cord-006229-7yoilsho	2168	8	the	the	DT
cord-006229-7yoilsho	2168	9	speed	speed	NN
cord-006229-7yoilsho	2168	10	of	of	IN
cord-006229-7yoilsho	2168	11	myocyte	myocyte	NNP
cord-006229-7yoilsho	2168	12	relaxation	relaxation	NN
cord-006229-7yoilsho	2168	13	.	.	.
cord-006229-7yoilsho	2169	1	Results	result	NNS
cord-006229-7yoilsho	2169	2	:	:	:
cord-006229-7yoilsho	2170	1	Under	under	IN
cord-006229-7yoilsho	2170	2	basal	basal	NN
cord-006229-7yoilsho	2170	3	conditions	condition	NNS
cord-006229-7yoilsho	2170	4	,	,	,
cord-006229-7yoilsho	2170	5	we	-PRON-	PRP
cord-006229-7yoilsho	2170	6	found	find	VBD
cord-006229-7yoilsho	2170	7	stronger	strong	JJR
cord-006229-7yoilsho	2170	8	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	2170	9	of	of	IN
cord-006229-7yoilsho	2170	10	PLN	PLN	NNP
cord-006229-7yoilsho	2170	11	pentamers	pentamer	NNS
cord-006229-7yoilsho	2170	12	than	than	IN
cord-006229-7yoilsho	2170	13	monomers	monomer	NNS
cord-006229-7yoilsho	2170	14	,	,	,
cord-006229-7yoilsho	2170	15	pointing	point	VBG
cord-006229-7yoilsho	2170	16	at	at	IN
cord-006229-7yoilsho	2170	17	pentamers	pentamer	NNS
cord-006229-7yoilsho	2170	18	as	as	IN
cord-006229-7yoilsho	2170	19	the	the	DT
cord-006229-7yoilsho	2170	20	preferred	preferred	JJ
cord-006229-7yoilsho	2170	21	PKA	PKA	NNP
cord-006229-7yoilsho	2170	22	target	target	NN
cord-006229-7yoilsho	2170	23	.	.	.
cord-006229-7yoilsho	2171	1	PLN	PLN	NNP
cord-006229-7yoilsho	2171	2	AFA	AFA	NNP
cord-006229-7yoilsho	2171	3	monomers	monomer	NNS
cord-006229-7yoilsho	2171	4	showed	show	VBD
cord-006229-7yoilsho	2171	5	3.3-fold	3.3-fold	CD
cord-006229-7yoilsho	2171	6	stronger	strong	JJR
cord-006229-7yoilsho	2171	7	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	2171	8	signals	signal	NNS
cord-006229-7yoilsho	2171	9	if	if	IN
cord-006229-7yoilsho	2171	10	pentamers	pentamer	NNS
cord-006229-7yoilsho	2171	11	were	be	VBD
cord-006229-7yoilsho	2171	12	absent	absent	JJ
cord-006229-7yoilsho	2171	13	(	(	-LRB-
cord-006229-7yoilsho	2171	14	P<0.0001	p<0.0001	JJ
cord-006229-7yoilsho	2171	15	)	)	-RRB-
cord-006229-7yoilsho	2171	16	.	.	.
cord-006229-7yoilsho	2172	1	Consistent	consistent	JJ
cord-006229-7yoilsho	2172	2	with	with	IN
cord-006229-7yoilsho	2172	3	a	a	DT
cord-006229-7yoilsho	2172	4	higher	high	JJR
cord-006229-7yoilsho	2172	5	basal	basal	NN
cord-006229-7yoilsho	2172	6	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	2172	7	of	of	IN
cord-006229-7yoilsho	2172	8	PLN	PLN	NNP
cord-006229-7yoilsho	2172	9	AFA	AFA	NNP
cord-006229-7yoilsho	2172	10	monomers	monomer	NNS
cord-006229-7yoilsho	2172	11	,	,	,
cord-006229-7yoilsho	2172	12	measurements	measurement	NNS
cord-006229-7yoilsho	2172	13	of	of	IN
cord-006229-7yoilsho	2172	14	calcium	calcium	NN
cord-006229-7yoilsho	2172	15	kinetics	kinetic	NNS
cord-006229-7yoilsho	2172	16	revealed	reveal	VBD
cord-006229-7yoilsho	2172	17	a	a	DT
cord-006229-7yoilsho	2172	18	faster	fast	JJR
cord-006229-7yoilsho	2172	19	decay	decay	NN
cord-006229-7yoilsho	2172	20	of	of	IN
cord-006229-7yoilsho	2172	21	calcium	calcium	NN
cord-006229-7yoilsho	2172	22	signals	signal	NNS
cord-006229-7yoilsho	2172	23	in	in	IN
cord-006229-7yoilsho	2172	24	TgAFA	TgAFA	NNP
cord-006229-7yoilsho	2172	25	compared	compare	VBN
cord-006229-7yoilsho	2172	26	with	with	IN
cord-006229-7yoilsho	2172	27	TgPLN	tgpln	DT
cord-006229-7yoilsho	2172	28	cardiomyocytes	cardiomyocyte	NNS
cord-006229-7yoilsho	2172	29	(	(	-LRB-
cord-006229-7yoilsho	2172	30	T	T	NNP
cord-006229-7yoilsho	2172	31	50	50	CD
cord-006229-7yoilsho	2172	32	%	%	NN
cord-006229-7yoilsho	2172	33	[	[	-LRB-
cord-006229-7yoilsho	2172	34	ms	ms	NNP
cord-006229-7yoilsho	2172	35	]	]	-RRB-
cord-006229-7yoilsho	2172	36	:	:	:
cord-006229-7yoilsho	2173	1	92±8	92±8	CD
cord-006229-7yoilsho	2173	2	and	and	CC
cord-006229-7yoilsho	2173	3	122±8	122±8	CD
cord-006229-7yoilsho	2173	4	,	,	,
cord-006229-7yoilsho	2173	5	respectively	respectively	RB
cord-006229-7yoilsho	2173	6	,	,	,
cord-006229-7yoilsho	2173	7	P<0.05	P<0.05	NNS
cord-006229-7yoilsho	2173	8	)	)	-RRB-
cord-006229-7yoilsho	2173	9	.	.	.
cord-006229-7yoilsho	2174	1	Notably	notably	RB
cord-006229-7yoilsho	2174	2	,	,	,
cord-006229-7yoilsho	2174	3	T	T	NNP
cord-006229-7yoilsho	2174	4	50	50	CD
cord-006229-7yoilsho	2174	5	%	%	NN
cord-006229-7yoilsho	2174	6	of	of	IN
cord-006229-7yoilsho	2174	7	PLN	PLN	NNP
cord-006229-7yoilsho	2174	8	-	-	HYPH
cord-006229-7yoilsho	2174	9	KO	KO	NNP
cord-006229-7yoilsho	2174	10	myocytes	myocyte	NNS
cord-006229-7yoilsho	2174	11	was	be	VBD
cord-006229-7yoilsho	2174	12	79±5ms	79±5ms	JJ
cord-006229-7yoilsho	2174	13	(	(	-LRB-
cord-006229-7yoilsho	2175	1	P=	P=	NNP
cord-006229-7yoilsho	2175	2	not	not	RB
cord-006229-7yoilsho	2175	3	significant	significant	JJ
cord-006229-7yoilsho	2175	4	versus	versus	IN
cord-006229-7yoilsho	2175	5	TgAFA	TgAFA	NNP
cord-006229-7yoilsho	2175	6	)	)	-RRB-
cord-006229-7yoilsho	2175	7	,	,	,
cord-006229-7yoilsho	2175	8	indicating	indicate	VBG
cord-006229-7yoilsho	2175	9	that	that	IN
cord-006229-7yoilsho	2175	10	the	the	DT
cord-006229-7yoilsho	2175	11	strong	strong	JJ
cord-006229-7yoilsho	2175	12	basal	basal	NN
cord-006229-7yoilsho	2175	13	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	2175	14	of	of	IN
cord-006229-7yoilsho	2175	15	monomers	monomer	NNS
cord-006229-7yoilsho	2175	16	leads	lead	VBZ
cord-006229-7yoilsho	2175	17	to	to	IN
cord-006229-7yoilsho	2175	18	near	near	IN
cord-006229-7yoilsho	2175	19	complete	complete	JJ
cord-006229-7yoilsho	2175	20	inactivation	inactivation	NN
cord-006229-7yoilsho	2175	21	of	of	IN
cord-006229-7yoilsho	2175	22	PLN	PLN	NNP
cord-006229-7yoilsho	2175	23	in	in	IN
cord-006229-7yoilsho	2175	24	TgAFA	TgAFA	NNP
cord-006229-7yoilsho	2175	25	.	.	.
cord-006229-7yoilsho	2176	1	Upon	upon	IN
cord-006229-7yoilsho	2176	2	stimulation	stimulation	NN
cord-006229-7yoilsho	2176	3	of	of	IN
cord-006229-7yoilsho	2176	4	PKA	PKA	NNP
cord-006229-7yoilsho	2176	5	,	,	,
cord-006229-7yoilsho	2176	6	PLN	PLN	NNP
cord-006229-7yoilsho	2176	7	monomer	monomer	NN
cord-006229-7yoilsho	2176	8	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	2176	9	and	and	CC
cord-006229-7yoilsho	2176	10	calcium	calcium	NN
cord-006229-7yoilsho	2176	11	kinetics	kinetic	NNS
cord-006229-7yoilsho	2176	12	of	of	IN
cord-006229-7yoilsho	2176	13	TgPLN	TgPLN	NNP
cord-006229-7yoilsho	2176	14	and	and	CC
cord-006229-7yoilsho	2176	15	TgAFA	TgAFA	NNP
cord-006229-7yoilsho	2176	16	mouse	mouse	NN
cord-006229-7yoilsho	2176	17	myocytes	myocyte	NNS
cord-006229-7yoilsho	2176	18	were	be	VBD
cord-006229-7yoilsho	2176	19	indistinguishable	indistinguishable	JJ
cord-006229-7yoilsho	2176	20	,	,	,
cord-006229-7yoilsho	2176	21	because	because	IN
cord-006229-7yoilsho	2176	22	monomer	monomer	NN
cord-006229-7yoilsho	2176	23	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	2176	24	and	and	CC
cord-006229-7yoilsho	2176	25	the	the	DT
cord-006229-7yoilsho	2176	26	speed	speed	NN
cord-006229-7yoilsho	2176	27	of	of	IN
cord-006229-7yoilsho	2176	28	cytosolic	cytosolic	JJ
cord-006229-7yoilsho	2176	29	Ca	Ca	NNP
cord-006229-7yoilsho	2176	30	2	2	CD
cord-006229-7yoilsho	2176	31	+	+	CC
cord-006229-7yoilsho	2176	32	clearance	clearance	NN
cord-006229-7yoilsho	2176	33	strongly	strongly	RB
cord-006229-7yoilsho	2176	34	increased	increase	VBD
cord-006229-7yoilsho	2176	35	only	only	RB
cord-006229-7yoilsho	2176	36	in	in	IN
cord-006229-7yoilsho	2176	37	TgPLN	TgPLN	NNP
cord-006229-7yoilsho	2176	38	.	.	.
cord-006229-7yoilsho	2177	1	Acceleration	acceleration	NN
cord-006229-7yoilsho	2177	2	of	of	IN
cord-006229-7yoilsho	2177	3	sarcomere	sarcomere	NN
cord-006229-7yoilsho	2177	4	relaxation	relaxation	NN
cord-006229-7yoilsho	2177	5	upon	upon	IN
cord-006229-7yoilsho	2177	6	PKA	PKA	NNP
cord-006229-7yoilsho	2177	7	stimulation	stimulation	NN
cord-006229-7yoilsho	2177	8	was	be	VBD
cord-006229-7yoilsho	2177	9	also	also	RB
cord-006229-7yoilsho	2177	10	more	more	RBR
cord-006229-7yoilsho	2177	11	pronounced	pronounced	JJ
cord-006229-7yoilsho	2177	12	in	in	IN
cord-006229-7yoilsho	2177	13	TgPLN	tgpln	DT
cord-006229-7yoilsho	2177	14	than	than	IN
cord-006229-7yoilsho	2177	15	in	in	IN
cord-006229-7yoilsho	2178	1	TgAFA	TgAFA	NNP
cord-006229-7yoilsho	2178	2	and	and	CC
cord-006229-7yoilsho	2178	3	PLN	PLN	NNP
cord-006229-7yoilsho	2178	4	-	-	HYPH
cord-006229-7yoilsho	2178	5	KO	KO	NNP
cord-006229-7yoilsho	2178	6	myocytes	myocyte	NNS
cord-006229-7yoilsho	2178	7	(	(	-LRB-
cord-006229-7yoilsho	2178	8	increase	increase	NN
cord-006229-7yoilsho	2178	9	of	of	IN
cord-006229-7yoilsho	2178	10	T	T	NNP
cord-006229-7yoilsho	2178	11	50	50	CD
cord-006229-7yoilsho	2178	12	%	%	NN
cord-006229-7yoilsho	2178	13	baseline	baseline	JJ
cord-006229-7yoilsho	2178	14	[	[	-LRB-
cord-006229-7yoilsho	2178	15	ms	ms	NNP
cord-006229-7yoilsho	2178	16	]	]	-RRB-
cord-006229-7yoilsho	2179	1	:	:	:
cord-006229-7yoilsho	2179	2	32±8	32±8	CD
cord-006229-7yoilsho	2179	3	in	in	IN
cord-006229-7yoilsho	2179	4	TgPLN	TgPLN	NNP
cord-006229-7yoilsho	2179	5	versus	versus	IN
cord-006229-7yoilsho	2179	6	7±4	7±4	CD
cord-006229-7yoilsho	2179	7	in	in	IN
cord-006229-7yoilsho	2179	8	TgAFA	TgAFA	NNP
cord-006229-7yoilsho	2179	9	-	-	HYPH
cord-006229-7yoilsho	2179	10	PLN	PLN	NNP
cord-006229-7yoilsho	2179	11	and	and	CC
cord-006229-7yoilsho	2179	12	5±7	5±7	CD
cord-006229-7yoilsho	2179	13	in	in	IN
cord-006229-7yoilsho	2179	14	PLN	PLN	NNP
cord-006229-7yoilsho	2179	15	-	-	HYPH
cord-006229-7yoilsho	2179	16	KO	KO	NNP
cord-006229-7yoilsho	2179	17	,	,	,
cord-006229-7yoilsho	2179	18	P<0.05	P<0.05	NNS
cord-006229-7yoilsho	2179	19	)	)	-RRB-
cord-006229-7yoilsho	2179	20	.	.	.
cord-006229-7yoilsho	2180	1	Even	even	RB
cord-006229-7yoilsho	2180	2	high	high	JJ
cord-006229-7yoilsho	2180	3	-	-	HYPH
cord-006229-7yoilsho	2180	4	dose	dose	NN
cord-006229-7yoilsho	2180	5	isoproterenol	isoproterenol	NN
cord-006229-7yoilsho	2180	6	induced	induce	VBN
cord-006229-7yoilsho	2180	7	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	2180	8	of	of	IN
cord-006229-7yoilsho	2180	9	only	only	RB
cord-006229-7yoilsho	2180	10	about	about	IN
cord-006229-7yoilsho	2180	11	half	half	NN
cord-006229-7yoilsho	2180	12	of	of	IN
cord-006229-7yoilsho	2180	13	all	all	DT
cord-006229-7yoilsho	2180	14	protomers	protomer	NNS
cord-006229-7yoilsho	2180	15	of	of	IN
cord-006229-7yoilsho	2180	16	PLN	PLN	NNP
cord-006229-7yoilsho	2180	17	pentamers	pentamer	NNS
cord-006229-7yoilsho	2180	18	suggesting	suggest	VBG
cord-006229-7yoilsho	2180	19	a	a	DT
cord-006229-7yoilsho	2180	20	high	high	JJ
cord-006229-7yoilsho	2180	21	capacity	capacity	NN
cord-006229-7yoilsho	2180	22	of	of	IN
cord-006229-7yoilsho	2180	23	pentamers	pentamer	NNS
cord-006229-7yoilsho	2180	24	to	to	TO
cord-006229-7yoilsho	2180	25	attenuate	attenuate	VB
cord-006229-7yoilsho	2180	26	monomer	monomer	NN
cord-006229-7yoilsho	2180	27	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	2180	28	by	by	IN
cord-006229-7yoilsho	2180	29	acting	act	VBG
cord-006229-7yoilsho	2180	30	as	as	IN
cord-006229-7yoilsho	2180	31	a	a	DT
cord-006229-7yoilsho	2180	32	phosphate	phosphate	NN
cord-006229-7yoilsho	2180	33	scavenger	scavenger	NN
cord-006229-7yoilsho	2180	34	.	.	.
cord-006229-7yoilsho	2181	1	Conclusions	conclusion	NNS
cord-006229-7yoilsho	2181	2	:	:	:
cord-006229-7yoilsho	2182	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	2182	2	data	datum	NNS
cord-006229-7yoilsho	2182	3	demonstrate	demonstrate	VBP
cord-006229-7yoilsho	2182	4	that	that	IN
cord-006229-7yoilsho	2182	5	PLN	PLN	NNP
cord-006229-7yoilsho	2182	6	pentamers	pentamer	NNS
cord-006229-7yoilsho	2182	7	reduce	reduce	VB
cord-006229-7yoilsho	2182	8	basal	basal	NN
cord-006229-7yoilsho	2182	9	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	2182	10	of	of	IN
cord-006229-7yoilsho	2182	11	PLN	PLN	NNP
cord-006229-7yoilsho	2182	12	monomers	monomer	NNS
cord-006229-7yoilsho	2182	13	in	in	IN
cord-006229-7yoilsho	2182	14	myocytes	myocyte	NNS
cord-006229-7yoilsho	2182	15	.	.	.
cord-006229-7yoilsho	2183	1	Nevertheless	nevertheless	RB
cord-006229-7yoilsho	2183	2	,	,	,
cord-006229-7yoilsho	2183	3	pentamers	pentamer	NNS
cord-006229-7yoilsho	2183	4	allow	allow	VBP
cord-006229-7yoilsho	2183	5	strong	strong	JJ
cord-006229-7yoilsho	2183	6	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	2183	7	of	of	IN
cord-006229-7yoilsho	2183	8	monomers	monomer	NNS
cord-006229-7yoilsho	2183	9	during	during	IN
cord-006229-7yoilsho	2183	10	beta	beta	JJ
cord-006229-7yoilsho	2183	11	-	-	HYPH
cord-006229-7yoilsho	2183	12	adrenergic	adrenergic	NN
cord-006229-7yoilsho	2183	13	stimulation	stimulation	NN
cord-006229-7yoilsho	2183	14	,	,	,
cord-006229-7yoilsho	2183	15	thereby	thereby	RB
cord-006229-7yoilsho	2183	16	extending	extend	VBG
cord-006229-7yoilsho	2183	17	the	the	DT
cord-006229-7yoilsho	2183	18	range	range	NN
cord-006229-7yoilsho	2183	19	within	within	IN
cord-006229-7yoilsho	2183	20	which	which	WDT
cord-006229-7yoilsho	2183	21	PLN	PLN	NNP
cord-006229-7yoilsho	2183	22	can	can	MD
cord-006229-7yoilsho	2183	23	modify	modify	VB
cord-006229-7yoilsho	2183	24	diastolic	diastolic	JJ
cord-006229-7yoilsho	2183	25	Ca	Ca	NNP
cord-006229-7yoilsho	2183	26	2	2	CD
cord-006229-7yoilsho	2183	27	+	+	SYM
cord-006229-7yoilsho	2183	28	kinetics	kinetic	NNS
cord-006229-7yoilsho	2183	29	and	and	CC
cord-006229-7yoilsho	2183	30	myocyte	myocyte	NNP
cord-006229-7yoilsho	2183	31	relaxation	relaxation	NN
cord-006229-7yoilsho	2183	32	.	.	.
cord-006229-7yoilsho	2184	1	Therapeutic	therapeutic	JJ
cord-006229-7yoilsho	2184	2	inhibition	inhibition	NN
cord-006229-7yoilsho	2184	3	of	of	IN
cord-006229-7yoilsho	2184	4	microRNAs	microRNAs	NNPS
cord-006229-7yoilsho	2184	5	is	be	VBZ
cord-006229-7yoilsho	2184	6	a	a	DT
cord-006229-7yoilsho	2184	7	promising	promising	JJ
cord-006229-7yoilsho	2184	8	field	field	NN
cord-006229-7yoilsho	2184	9	in	in	IN
cord-006229-7yoilsho	2184	10	cardiovascular	cardiovascular	JJ
cord-006229-7yoilsho	2184	11	research	research	NN
cord-006229-7yoilsho	2184	12	.	.	.
cord-006229-7yoilsho	2185	1	Vector	vector	NN
cord-006229-7yoilsho	2185	2	-	-	HYPH
cord-006229-7yoilsho	2185	3	based	base	VBN
cord-006229-7yoilsho	2185	4	overexpression	overexpression	NN
cord-006229-7yoilsho	2185	5	of	of	IN
cord-006229-7yoilsho	2185	6	an	an	DT
cord-006229-7yoilsho	2185	7	inhibitor	inhibitor	NN
cord-006229-7yoilsho	2185	8	construct	construct	NN
cord-006229-7yoilsho	2185	9	(	(	-LRB-
cord-006229-7yoilsho	2185	10	e.g.	e.g.	IN
cord-006229-7yoilsho	2185	11	microRNA	microRNA	NNP
cord-006229-7yoilsho	2185	12	sponge	sponge	NNP
cord-006229-7yoilsho	2185	13	)	)	-RRB-
cord-006229-7yoilsho	2185	14	is	be	VBZ
cord-006229-7yoilsho	2185	15	one	one	CD
cord-006229-7yoilsho	2185	16	approach	approach	NN
cord-006229-7yoilsho	2185	17	to	to	TO
cord-006229-7yoilsho	2185	18	achieve	achieve	VB
cord-006229-7yoilsho	2185	19	sustained	sustained	JJ
cord-006229-7yoilsho	2185	20	inhibition	inhibition	NN
cord-006229-7yoilsho	2185	21	with	with	IN
cord-006229-7yoilsho	2185	22	potential	potential	JJ
cord-006229-7yoilsho	2185	23	applicability	applicability	NN
cord-006229-7yoilsho	2185	24	in	in	IN
cord-006229-7yoilsho	2185	25	humans	human	NNS
cord-006229-7yoilsho	2185	26	.	.	.
cord-006229-7yoilsho	2186	1	Yet	yet	RB
cord-006229-7yoilsho	2186	2	the	the	DT
cord-006229-7yoilsho	2186	3	strength	strength	NN
cord-006229-7yoilsho	2186	4	of	of	IN
cord-006229-7yoilsho	2186	5	expression	expression	NN
cord-006229-7yoilsho	2186	6	achieved	achieve	VBN
cord-006229-7yoilsho	2186	7	by	by	IN
cord-006229-7yoilsho	2186	8	the	the	DT
cord-006229-7yoilsho	2186	9	currently	currently	RB
cord-006229-7yoilsho	2186	10	available	available	JJ
cord-006229-7yoilsho	2186	11	gene	gene	NN
cord-006229-7yoilsho	2186	12	therapy	therapy	NN
cord-006229-7yoilsho	2186	13	vectors	vector	NNS
cord-006229-7yoilsho	2186	14	(	(	-LRB-
cord-006229-7yoilsho	2186	15	e.g.	e.g.	RB
cord-006229-7yoilsho	2186	16	AAVs	AAVs	NNP
cord-006229-7yoilsho	2186	17	)	)	-RRB-
cord-006229-7yoilsho	2186	18	in	in	IN
cord-006229-7yoilsho	2186	19	humans	human	NNS
cord-006229-7yoilsho	2186	20	remains	remain	VBZ
cord-006229-7yoilsho	2186	21	a	a	DT
cord-006229-7yoilsho	2186	22	limiting	limit	VBG
cord-006229-7yoilsho	2186	23	factor	factor	NN
cord-006229-7yoilsho	2186	24	,	,	,
cord-006229-7yoilsho	2186	25	therefore	therefore	RB
cord-006229-7yoilsho	2186	26	inhibitory	inhibitory	JJ
cord-006229-7yoilsho	2186	27	constructs	construct	NNS
cord-006229-7yoilsho	2186	28	with	with	IN
cord-006229-7yoilsho	2186	29	increased	increase	VBN
cord-006229-7yoilsho	2186	30	potency	potency	NN
cord-006229-7yoilsho	2186	31	would	would	MD
cord-006229-7yoilsho	2186	32	provide	provide	VB
cord-006229-7yoilsho	2186	33	an	an	DT
cord-006229-7yoilsho	2186	34	improvement	improvement	NN
cord-006229-7yoilsho	2186	35	of	of	IN
cord-006229-7yoilsho	2186	36	this	this	DT
cord-006229-7yoilsho	2186	37	approach	approach	NN
cord-006229-7yoilsho	2186	38	and	and	CC
cord-006229-7yoilsho	2186	39	bring	bring	VB
cord-006229-7yoilsho	2186	40	it	-PRON-	PRP
cord-006229-7yoilsho	2186	41	closer	close	RBR
cord-006229-7yoilsho	2186	42	to	to	IN
cord-006229-7yoilsho	2186	43	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	2186	44	application	application	NN
cord-006229-7yoilsho	2186	45	.	.	.
cord-006229-7yoilsho	2187	1	MicroRNAs	microrna	NNS
cord-006229-7yoilsho	2187	2	are	be	VBP
cord-006229-7yoilsho	2187	3	believed	believe	VBN
cord-006229-7yoilsho	2187	4	to	to	TO
cord-006229-7yoilsho	2187	5	discriminate	discriminate	VB
cord-006229-7yoilsho	2187	6	between	between	IN
cord-006229-7yoilsho	2187	7	potential	potential	JJ
cord-006229-7yoilsho	2187	8	binding	bind	VBG
cord-006229-7yoilsho	2187	9	sites	site	NNS
cord-006229-7yoilsho	2187	10	,	,	,
cord-006229-7yoilsho	2187	11	based	base	VBN
cord-006229-7yoilsho	2187	12	on	on	IN
cord-006229-7yoilsho	2187	13	additional	additional	JJ
cord-006229-7yoilsho	2187	14	factors	factor	NNS
cord-006229-7yoilsho	2187	15	provided	provide	VBN
cord-006229-7yoilsho	2187	16	by	by	IN
cord-006229-7yoilsho	2187	17	the	the	DT
cord-006229-7yoilsho	2187	18	endogenous	endogenous	JJ
cord-006229-7yoilsho	2187	19	untranslated	untranslated	JJ
cord-006229-7yoilsho	2187	20	regions	region	NNS
cord-006229-7yoilsho	2187	21	at	at	IN
cord-006229-7yoilsho	2187	22	the	the	DT
cord-006229-7yoilsho	2187	23	3	3	CD
cord-006229-7yoilsho	2187	24	'	'	NN
cord-006229-7yoilsho	2187	25	end	end	NN
cord-006229-7yoilsho	2187	26	of	of	IN
cord-006229-7yoilsho	2187	27	mRNAs	mRNAs	NNPS
cord-006229-7yoilsho	2187	28	(	(	-LRB-
cord-006229-7yoilsho	2187	29	3	3	CD
cord-006229-7yoilsho	2187	30	'	'	POS
cord-006229-7yoilsho	2187	31	UTRs	utr	NNS
cord-006229-7yoilsho	2187	32	)	)	-RRB-
cord-006229-7yoilsho	2187	33	and	and	CC
cord-006229-7yoilsho	2187	34	the	the	DT
cord-006229-7yoilsho	2187	35	proteins	protein	NNS
cord-006229-7yoilsho	2187	36	that	that	WDT
cord-006229-7yoilsho	2187	37	are	be	VBP
cord-006229-7yoilsho	2187	38	bound	bind	VBN
cord-006229-7yoilsho	2187	39	to	to	IN
cord-006229-7yoilsho	2187	40	them	-PRON-	PRP
cord-006229-7yoilsho	2187	41	.	.	.
cord-006229-7yoilsho	2188	1	Aim	aim	VB
cord-006229-7yoilsho	2188	2	of	of	IN
cord-006229-7yoilsho	2188	3	this	this	DT
cord-006229-7yoilsho	2188	4	project	project	NN
cord-006229-7yoilsho	2188	5	was	be	VBD
cord-006229-7yoilsho	2188	6	to	to	TO
cord-006229-7yoilsho	2188	7	investigate	investigate	VB
cord-006229-7yoilsho	2188	8	whether	whether	IN
cord-006229-7yoilsho	2188	9	selected	select	VBN
cord-006229-7yoilsho	2188	10	endogenous	endogenous	JJ
cord-006229-7yoilsho	2188	11	3	3	CD
cord-006229-7yoilsho	2188	12	'	'	''
cord-006229-7yoilsho	2188	13	UTRs	utr	NNS
cord-006229-7yoilsho	2188	14	can	can	MD
cord-006229-7yoilsho	2188	15	likewise	likewise	RB
cord-006229-7yoilsho	2188	16	increase	increase	VB
cord-006229-7yoilsho	2188	17	the	the	DT
cord-006229-7yoilsho	2188	18	potency	potency	NN
cord-006229-7yoilsho	2188	19	of	of	IN
cord-006229-7yoilsho	2188	20	microRNA	microRNA	NNP
cord-006229-7yoilsho	2188	21	inhibitory	inhibitory	JJ
cord-006229-7yoilsho	2188	22	constructs	construct	NNS
cord-006229-7yoilsho	2188	23	.	.	.
cord-006229-7yoilsho	2189	1	To	to	IN
cord-006229-7yoilsho	2189	2	this	this	DT
cord-006229-7yoilsho	2189	3	end	end	NN
cord-006229-7yoilsho	2189	4	several	several	JJ
cord-006229-7yoilsho	2189	5	known	know	VBN
cord-006229-7yoilsho	2189	6	targets	target	NNS
cord-006229-7yoilsho	2189	7	for	for	IN
cord-006229-7yoilsho	2189	8	a	a	DT
cord-006229-7yoilsho	2189	9	cardiac	cardiac	JJ
cord-006229-7yoilsho	2189	10	microRNA	microRNA	NNP
cord-006229-7yoilsho	2189	11	were	be	VBD
cord-006229-7yoilsho	2189	12	selected	select	VBN
cord-006229-7yoilsho	2189	13	and	and	CC
cord-006229-7yoilsho	2189	14	their	-PRON-	PRP$
cord-006229-7yoilsho	2189	15	relative	relative	JJ
cord-006229-7yoilsho	2189	16	potencies	potency	NNS
cord-006229-7yoilsho	2189	17	of	of	IN
cord-006229-7yoilsho	2189	18	microRNA	microRNA	NNP
cord-006229-7yoilsho	2189	19	inhibition	inhibition	NN
cord-006229-7yoilsho	2189	20	was	be	VBD
cord-006229-7yoilsho	2189	21	compared	compare	VBN
cord-006229-7yoilsho	2189	22	.	.	.
cord-006229-7yoilsho	2190	1	To	to	TO
cord-006229-7yoilsho	2190	2	accurately	accurately	RB
cord-006229-7yoilsho	2190	3	assess	assess	VB
cord-006229-7yoilsho	2190	4	changes	change	NNS
cord-006229-7yoilsho	2190	5	in	in	IN
cord-006229-7yoilsho	2190	6	the	the	DT
cord-006229-7yoilsho	2190	7	activity	activity	NN
cord-006229-7yoilsho	2190	8	of	of	IN
cord-006229-7yoilsho	2190	9	the	the	DT
cord-006229-7yoilsho	2190	10	respective	respective	JJ
cord-006229-7yoilsho	2190	11	microRNAs	microrna	NNS
cord-006229-7yoilsho	2190	12	we	-PRON-	PRP
cord-006229-7yoilsho	2190	13	constructed	construct	VBD
cord-006229-7yoilsho	2190	14	dual	dual	JJ
cord-006229-7yoilsho	2190	15	-	-	HYPH
cord-006229-7yoilsho	2190	16	fluorescent	fluorescent	JJ
cord-006229-7yoilsho	2190	17	reporter	reporter	NN
cord-006229-7yoilsho	2190	18	plasmids	plasmid	NNS
cord-006229-7yoilsho	2190	19	and	and	CC
cord-006229-7yoilsho	2190	20	established	establish	VBD
cord-006229-7yoilsho	2190	21	an	an	DT
cord-006229-7yoilsho	2190	22	automated	automate	VBN
cord-006229-7yoilsho	2190	23	fluorescent	fluorescent	JJ
cord-006229-7yoilsho	2190	24	microscopy	microscopy	NN
cord-006229-7yoilsho	2190	25	acquisition	acquisition	NN
cord-006229-7yoilsho	2190	26	and	and	CC
cord-006229-7yoilsho	2190	27	analysis	analysis	NN
cord-006229-7yoilsho	2190	28	pipeline	pipeline	NN
cord-006229-7yoilsho	2190	29	.	.	.
cord-006229-7yoilsho	2191	1	Among	among	IN
cord-006229-7yoilsho	2191	2	several	several	JJ
cord-006229-7yoilsho	2191	3	tested	test	VBN
cord-006229-7yoilsho	2191	4	UTR	UTR	NNP
cord-006229-7yoilsho	2191	5	constructs	construct	NNS
cord-006229-7yoilsho	2191	6	we	-PRON-	PRP
cord-006229-7yoilsho	2191	7	found	find	VBD
cord-006229-7yoilsho	2191	8	one	one	CD
cord-006229-7yoilsho	2191	9	which	which	WDT
cord-006229-7yoilsho	2191	10	strongly	strongly	RB
cord-006229-7yoilsho	2191	11	increased	increase	VBD
cord-006229-7yoilsho	2191	12	the	the	DT
cord-006229-7yoilsho	2191	13	inhibitory	inhibitory	JJ
cord-006229-7yoilsho	2191	14	potency	potency	NN
cord-006229-7yoilsho	2191	15	of	of	IN
cord-006229-7yoilsho	2191	16	the	the	DT
cord-006229-7yoilsho	2191	17	microRNA	microRNA	NNP
cord-006229-7yoilsho	2191	18	binding	binding	NN
cord-006229-7yoilsho	2191	19	site	site	NN
cord-006229-7yoilsho	2191	20	in	in	IN
cord-006229-7yoilsho	2191	21	primary	primary	JJ
cord-006229-7yoilsho	2191	22	rat	rat	NN
cord-006229-7yoilsho	2191	23	cardiac	cardiac	NN
cord-006229-7yoilsho	2191	24	myocytes	myocyte	NNS
cord-006229-7yoilsho	2191	25	(	(	-LRB-
cord-006229-7yoilsho	2191	26	NRCMs	NRCMs	NNP
cord-006229-7yoilsho	2191	27	)	)	-RRB-
cord-006229-7yoilsho	2191	28	.	.	.
cord-006229-7yoilsho	2192	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	2192	2	a	a	DT
cord-006229-7yoilsho	2192	3	similar	similar	JJ
cord-006229-7yoilsho	2192	4	effect	effect	NN
cord-006229-7yoilsho	2192	5	was	be	VBD
cord-006229-7yoilsho	2192	6	obtained	obtain	VBN
cord-006229-7yoilsho	2192	7	when	when	WRB
cord-006229-7yoilsho	2192	8	the	the	DT
cord-006229-7yoilsho	2192	9	binding	binding	NN
cord-006229-7yoilsho	2192	10	site	site	NN
cord-006229-7yoilsho	2192	11	was	be	VBD
cord-006229-7yoilsho	2192	12	exchanged	exchange	VBN
cord-006229-7yoilsho	2192	13	for	for	IN
cord-006229-7yoilsho	2192	14	that	that	DT
cord-006229-7yoilsho	2192	15	of	of	IN
cord-006229-7yoilsho	2192	16	a	a	DT
cord-006229-7yoilsho	2192	17	different	different	JJ
cord-006229-7yoilsho	2192	18	microRNA	microrna	NN
cord-006229-7yoilsho	2192	19	and	and	CC
cord-006229-7yoilsho	2192	20	analyzed	analyze	VBD
cord-006229-7yoilsho	2192	21	in	in	IN
cord-006229-7yoilsho	2192	22	the	the	DT
cord-006229-7yoilsho	2192	23	NIH-3T3	NIH-3T3	NNP
cord-006229-7yoilsho	2192	24	fibroblast	fibroblast	NN
cord-006229-7yoilsho	2192	25	cell	cell	NN
cord-006229-7yoilsho	2192	26	line	line	NN
cord-006229-7yoilsho	2192	27	.	.	.
cord-006229-7yoilsho	2193	1	We	-PRON-	PRP
cord-006229-7yoilsho	2193	2	therefore	therefore	RB
cord-006229-7yoilsho	2193	3	conclude	conclude	VBP
cord-006229-7yoilsho	2193	4	that	that	IN
cord-006229-7yoilsho	2193	5	endogenous	endogenous	JJ
cord-006229-7yoilsho	2193	6	UTR	UTR	NNP
cord-006229-7yoilsho	2193	7	contexts	context	NNS
cord-006229-7yoilsho	2193	8	can	can	MD
cord-006229-7yoilsho	2193	9	indeed	indeed	RB
cord-006229-7yoilsho	2193	10	be	be	VB
cord-006229-7yoilsho	2193	11	successfully	successfully	RB
cord-006229-7yoilsho	2193	12	applied	apply	VBN
cord-006229-7yoilsho	2193	13	to	to	TO
cord-006229-7yoilsho	2193	14	increase	increase	VB
cord-006229-7yoilsho	2193	15	the	the	DT
cord-006229-7yoilsho	2193	16	potency	potency	NN
cord-006229-7yoilsho	2193	17	of	of	IN
cord-006229-7yoilsho	2193	18	vector	vector	NN
cord-006229-7yoilsho	2193	19	-	-	HYPH
cord-006229-7yoilsho	2193	20	based	base	VBN
cord-006229-7yoilsho	2193	21	microRNA	microRNA	NNP
cord-006229-7yoilsho	2193	22	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	2193	23	.	.	.
cord-006229-7yoilsho	2194	1	The	the	DT
cord-006229-7yoilsho	2194	2	G	g	NN
cord-006229-7yoilsho	2194	3	-	-	HYPH
cord-006229-7yoilsho	2194	4	protein	protein	NN
cord-006229-7yoilsho	2194	5	-	-	HYPH
cord-006229-7yoilsho	2194	6	coupled	couple	VBN
cord-006229-7yoilsho	2194	7	protease	protease	NN
cord-006229-7yoilsho	2194	8	-	-	HYPH
cord-006229-7yoilsho	2194	9	activated	activate	VBN
cord-006229-7yoilsho	2194	10	receptor-2	receptor-2	NNP
cord-006229-7yoilsho	2194	11	(	(	-LRB-
cord-006229-7yoilsho	2194	12	PAR2	PAR2	NNP
cord-006229-7yoilsho	2194	13	)	)	-RRB-
cord-006229-7yoilsho	2194	14	regulates	regulate	VBZ
cord-006229-7yoilsho	2194	15	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	2194	16	responses	response	NNS
cord-006229-7yoilsho	2194	17	including	include	VBG
cord-006229-7yoilsho	2194	18	monocyte	monocyte	NNP
cord-006229-7yoilsho	2194	19	migration	migration	NN
cord-006229-7yoilsho	2194	20	and	and	CC
cord-006229-7yoilsho	2194	21	cytokine	cytokine	NN
cord-006229-7yoilsho	2194	22	release	release	NN
cord-006229-7yoilsho	2194	23	.	.	.
cord-006229-7yoilsho	2195	1	PAR2	PAR2	NNP
cord-006229-7yoilsho	2195	2	is	be	VBZ
cord-006229-7yoilsho	2195	3	activated	activate	VBN
cord-006229-7yoilsho	2195	4	by	by	IN
cord-006229-7yoilsho	2195	5	the	the	DT
cord-006229-7yoilsho	2195	6	coagulation	coagulation	NN
cord-006229-7yoilsho	2195	7	factor	factor	NN
cord-006229-7yoilsho	2195	8	-	-	:
cord-006229-7yoilsho	2195	9	Xa	Xa	NNP
cord-006229-7yoilsho	2195	10	or	or	CC
cord-006229-7yoilsho	2195	11	by	by	IN
cord-006229-7yoilsho	2195	12	the	the	DT
cord-006229-7yoilsho	2195	13	tissue	tissue	NN
cord-006229-7yoilsho	2195	14	-	-	HYPH
cord-006229-7yoilsho	2195	15	factor	factor	NN
cord-006229-7yoilsho	2195	16	(	(	-LRB-
cord-006229-7yoilsho	2195	17	TF)/Factor	TF)/Factor	NNP
cord-006229-7yoilsho	2195	18	VIIa	VIIa	NNS
cord-006229-7yoilsho	2195	19	complex	complex	JJ
cord-006229-7yoilsho	2195	20	.	.	.
cord-006229-7yoilsho	2196	1	The	the	DT
cord-006229-7yoilsho	2196	2	immunomodulatory	immunomodulatory	JJ
cord-006229-7yoilsho	2196	3	lipid	lipid	NN
cord-006229-7yoilsho	2196	4	sphingosine-1-phosphate	sphingosine-1-phosphate	NNP
cord-006229-7yoilsho	2196	5	(	(	-LRB-
cord-006229-7yoilsho	2196	6	S1P	s1p	NN
cord-006229-7yoilsho	2196	7	)	)	-RRB-
cord-006229-7yoilsho	2196	8	is	be	VBZ
cord-006229-7yoilsho	2196	9	released	release	VBN
cord-006229-7yoilsho	2196	10	from	from	IN
cord-006229-7yoilsho	2196	11	activated	activate	VBN
cord-006229-7yoilsho	2196	12	platelets	platelet	NNS
cord-006229-7yoilsho	2196	13	and	and	CC
cord-006229-7yoilsho	2196	14	interlinks	interlink	NNS
cord-006229-7yoilsho	2196	15	blood	blood	NN
cord-006229-7yoilsho	2196	16	coagulation	coagulation	NN
cord-006229-7yoilsho	2196	17	and	and	CC
cord-006229-7yoilsho	2196	18	inflammation	inflammation	NN
cord-006229-7yoilsho	2196	19	.	.	.
cord-006229-7yoilsho	2197	1	This	this	DT
cord-006229-7yoilsho	2197	2	study	study	NN
cord-006229-7yoilsho	2197	3	investigates	investigate	VBZ
cord-006229-7yoilsho	2197	4	the	the	DT
cord-006229-7yoilsho	2197	5	impact	impact	NN
cord-006229-7yoilsho	2197	6	of	of	IN
cord-006229-7yoilsho	2197	7	S1P	s1p	NN
cord-006229-7yoilsho	2197	8	on	on	IN
cord-006229-7yoilsho	2197	9	the	the	DT
cord-006229-7yoilsho	2197	10	expression	expression	NN
cord-006229-7yoilsho	2197	11	of	of	IN
cord-006229-7yoilsho	2197	12	PAR2	PAR2	NNP
cord-006229-7yoilsho	2197	13	,	,	,
cord-006229-7yoilsho	2197	14	TF	TF	NNP
cord-006229-7yoilsho	2197	15	and	and	CC
cord-006229-7yoilsho	2197	16	of	of	IN
cord-006229-7yoilsho	2197	17	the	the	DT
cord-006229-7yoilsho	2197	18	anticoagulant	anticoagulant	JJ
cord-006229-7yoilsho	2197	19	protein	protein	NN
cord-006229-7yoilsho	2197	20	thrombomodulin	thrombomodulin	NN
cord-006229-7yoilsho	2197	21	(	(	-LRB-
cord-006229-7yoilsho	2197	22	TM	TM	NNP
cord-006229-7yoilsho	2197	23	)	)	-RRB-
cord-006229-7yoilsho	2197	24	in	in	IN
cord-006229-7yoilsho	2197	25	human	human	JJ
cord-006229-7yoilsho	2197	26	monocytes	monocyte	NNS
cord-006229-7yoilsho	2197	27	and	and	CC
cord-006229-7yoilsho	2197	28	after	after	IN
cord-006229-7yoilsho	2197	29	PMA	PMA	NNP
cord-006229-7yoilsho	2197	30	-	-	HYPH
cord-006229-7yoilsho	2197	31	induced	induce	VBN
cord-006229-7yoilsho	2197	32	differentiation	differentiation	NN
cord-006229-7yoilsho	2197	33	into	into	IN
cord-006229-7yoilsho	2197	34	macrophage	macrophage	NN
cord-006229-7yoilsho	2197	35	-	-	HYPH
cord-006229-7yoilsho	2197	36	like	like	JJ
cord-006229-7yoilsho	2197	37	cells	cell	NNS
cord-006229-7yoilsho	2197	38	.	.	.
cord-006229-7yoilsho	2198	1	Monocytic	Monocytic	NNP
cord-006229-7yoilsho	2198	2	THP1	THP1	NNP
cord-006229-7yoilsho	2198	3	and	and	CC
cord-006229-7yoilsho	2198	4	U937	U937	NNP
cord-006229-7yoilsho	2198	5	cell	cell	NN
cord-006229-7yoilsho	2198	6	lines	line	NNS
cord-006229-7yoilsho	2198	7	were	be	VBD
cord-006229-7yoilsho	2198	8	used	use	VBN
cord-006229-7yoilsho	2198	9	as	as	IN
cord-006229-7yoilsho	2198	10	human	human	JJ
cord-006229-7yoilsho	2198	11	monocyte	monocyte	NNP
cord-006229-7yoilsho	2198	12	models	model	NNS
cord-006229-7yoilsho	2198	13	.	.	.
cord-006229-7yoilsho	2199	1	Primary	primary	JJ
cord-006229-7yoilsho	2199	2	monocytes	monocyte	NNS
cord-006229-7yoilsho	2199	3	were	be	VBD
cord-006229-7yoilsho	2199	4	isolated	isolate	VBN
cord-006229-7yoilsho	2199	5	from	from	IN
cord-006229-7yoilsho	2199	6	healthy	healthy	JJ
cord-006229-7yoilsho	2199	7	volunteers	volunteer	NNS
cord-006229-7yoilsho	2199	8	using	use	VBG
cord-006229-7yoilsho	2199	9	a	a	DT
cord-006229-7yoilsho	2199	10	magnetic	magnetic	JJ
cord-006229-7yoilsho	2199	11	bead	bead	NN
cord-006229-7yoilsho	2199	12	-	-	HYPH
cord-006229-7yoilsho	2199	13	based	base	VBN
cord-006229-7yoilsho	2199	14	monocyte	monocyte	NNP
cord-006229-7yoilsho	2199	15	isolation	isolation	NNP
cord-006229-7yoilsho	2199	16	kit	kit	NN
cord-006229-7yoilsho	2199	17	.	.	.
cord-006229-7yoilsho	2200	1	Expression	expression	NN
cord-006229-7yoilsho	2200	2	of	of	IN
cord-006229-7yoilsho	2200	3	PAR2	PAR2	NNP
cord-006229-7yoilsho	2200	4	,	,	,
cord-006229-7yoilsho	2200	5	TF	TF	NNP
cord-006229-7yoilsho	2200	6	and	and	CC
cord-006229-7yoilsho	2200	7	TM	TM	NNP
cord-006229-7yoilsho	2200	8	was	be	VBD
cord-006229-7yoilsho	2200	9	measured	measure	VBN
cord-006229-7yoilsho	2200	10	by	by	IN
cord-006229-7yoilsho	2200	11	quantitative	quantitative	JJ
cord-006229-7yoilsho	2200	12	real	real	JJ
cord-006229-7yoilsho	2200	13	-	-	HYPH
cord-006229-7yoilsho	2200	14	time	time	NN
cord-006229-7yoilsho	2200	15	PCR	PCR	NNP
cord-006229-7yoilsho	2200	16	and	and	CC
cord-006229-7yoilsho	2200	17	Western	western	JJ
cord-006229-7yoilsho	2200	18	blotting	blotting	NN
cord-006229-7yoilsho	2200	19	.	.	.
cord-006229-7yoilsho	2201	1	Differentiation	differentiation	NN
cord-006229-7yoilsho	2201	2	of	of	IN
cord-006229-7yoilsho	2201	3	monocytes	monocyte	NNS
cord-006229-7yoilsho	2201	4	into	into	IN
cord-006229-7yoilsho	2201	5	macrophage	macrophage	NN
cord-006229-7yoilsho	2201	6	-	-	HYPH
cord-006229-7yoilsho	2201	7	like	like	JJ
cord-006229-7yoilsho	2201	8	cells	cell	NNS
cord-006229-7yoilsho	2201	9	was	be	VBD
cord-006229-7yoilsho	2201	10	induced	induce	VBN
cord-006229-7yoilsho	2201	11	by	by	IN
cord-006229-7yoilsho	2201	12	incubation	incubation	NN
cord-006229-7yoilsho	2201	13	with	with	IN
cord-006229-7yoilsho	2201	14	50	50	CD
cord-006229-7yoilsho	2201	15	ng	ng	NN
cord-006229-7yoilsho	2201	16	/	/	SYM
cord-006229-7yoilsho	2201	17	ml	ml	NN
cord-006229-7yoilsho	2201	18	PMA	PMA	NNP
cord-006229-7yoilsho	2201	19	(	(	-LRB-
cord-006229-7yoilsho	2202	1	phorbol	phorbol	NNP
cord-006229-7yoilsho	2202	2	12-myristate	12-myristate	CD
cord-006229-7yoilsho	2202	3	13-acetate	13-acetate	CD
cord-006229-7yoilsho	2202	4	)	)	-RRB-
cord-006229-7yoilsho	2202	5	over	over	IN
cord-006229-7yoilsho	2202	6	72	72	CD
cord-006229-7yoilsho	2202	7	h.	h.	NN
cord-006229-7yoilsho	2202	8	Calibrated	calibrate	VBN
cord-006229-7yoilsho	2202	9	automated	automate	VBN
cord-006229-7yoilsho	2202	10	thrombin	thrombin	NN
cord-006229-7yoilsho	2203	1	(	(	-LRB-
cord-006229-7yoilsho	2203	2	CAT	cat	NN
cord-006229-7yoilsho	2203	3	)	)	-RRB-
cord-006229-7yoilsho	2203	4	generation	generation	NN
cord-006229-7yoilsho	2203	5	was	be	VBD
cord-006229-7yoilsho	2203	6	determined	determine	VBN
cord-006229-7yoilsho	2203	7	in	in	IN
cord-006229-7yoilsho	2203	8	plateletrich	plateletrich	JJ
cord-006229-7yoilsho	2203	9	plasma	plasma	NN
cord-006229-7yoilsho	2203	10	from	from	IN
cord-006229-7yoilsho	2203	11	healthy	healthy	JJ
cord-006229-7yoilsho	2203	12	volunteers	volunteer	NNS
cord-006229-7yoilsho	2203	13	.	.	.
cord-006229-7yoilsho	2204	1	In	in	IN
cord-006229-7yoilsho	2204	2	THP1	THP1	NNP
cord-006229-7yoilsho	2204	3	and	and	CC
cord-006229-7yoilsho	2204	4	U937	U937	NNP
cord-006229-7yoilsho	2204	5	cells	cell	NNS
cord-006229-7yoilsho	2204	6	S1P	S1P	VBD
cord-006229-7yoilsho	2204	7	induced	induce	VBN
cord-006229-7yoilsho	2204	8	a	a	DT
cord-006229-7yoilsho	2204	9	time-(1	time-(1	NN
cord-006229-7yoilsho	2205	1	to	to	IN
cord-006229-7yoilsho	2205	2	24	24	CD
cord-006229-7yoilsho	2205	3	h	h	NN
cord-006229-7yoilsho	2205	4	)	)	-RRB-
cord-006229-7yoilsho	2205	5	and	and	CC
cord-006229-7yoilsho	2205	6	concentration	concentration	NN
cord-006229-7yoilsho	2205	7	-	-	HYPH
cord-006229-7yoilsho	2205	8	dependent	dependent	JJ
cord-006229-7yoilsho	2205	9	(	(	-LRB-
cord-006229-7yoilsho	2205	10	0.1	0.1	CD
cord-006229-7yoilsho	2205	11	to	to	TO
cord-006229-7yoilsho	2205	12	10	10	CD
cord-006229-7yoilsho	2205	13	µM	µm	NN
cord-006229-7yoilsho	2205	14	)	)	-RRB-
cord-006229-7yoilsho	2206	1	significant	significant	JJ
cord-006229-7yoilsho	2206	2	upregulation	upregulation	NN
cord-006229-7yoilsho	2206	3	of	of	IN
cord-006229-7yoilsho	2206	4	PAR2	PAR2	NNP
cord-006229-7yoilsho	2206	5	mRNA	mRNA	NNP
cord-006229-7yoilsho	2206	6	and	and	CC
cord-006229-7yoilsho	2206	7	total	total	JJ
cord-006229-7yoilsho	2206	8	protein	protein	NN
cord-006229-7yoilsho	2206	9	expression	expression	NN
cord-006229-7yoilsho	2206	10	.	.	.
cord-006229-7yoilsho	2207	1	PAR2	par2	JJ
cord-006229-7yoilsho	2207	2	total	total	JJ
cord-006229-7yoilsho	2207	3	protein	protein	NN
cord-006229-7yoilsho	2207	4	was	be	VBD
cord-006229-7yoilsho	2207	5	upregulated	upregulate	VBN
cord-006229-7yoilsho	2207	6	maximally	maximally	RB
cord-006229-7yoilsho	2207	7	(	(	-LRB-
cord-006229-7yoilsho	2207	8	about	about	RB
cord-006229-7yoilsho	2207	9	1.5-fold	1.5-fold	CD
cord-006229-7yoilsho	2207	10	,	,	,
cord-006229-7yoilsho	2207	11	n=7	n=7	NNS
cord-006229-7yoilsho	2207	12	)	)	-RRB-
cord-006229-7yoilsho	2207	13	with	with	IN
cord-006229-7yoilsho	2207	14	1	1	CD
cord-006229-7yoilsho	2207	15	µM	µm	CD
cord-006229-7yoilsho	2207	16	S1P	s1p	NN
cord-006229-7yoilsho	2207	17	after	after	IN
cord-006229-7yoilsho	2207	18	16	16	CD
cord-006229-7yoilsho	2207	19	h	h	NN
cord-006229-7yoilsho	2207	20	incubation	incubation	NN
cord-006229-7yoilsho	2207	21	.	.	.
cord-006229-7yoilsho	2208	1	Comparable	comparable	JJ
cord-006229-7yoilsho	2208	2	effects	effect	NNS
cord-006229-7yoilsho	2208	3	were	be	VBD
cord-006229-7yoilsho	2208	4	seen	see	VBN
cord-006229-7yoilsho	2208	5	in	in	IN
cord-006229-7yoilsho	2208	6	human	human	JJ
cord-006229-7yoilsho	2208	7	primary	primary	JJ
cord-006229-7yoilsho	2208	8	monocytes	monocyte	NNS
cord-006229-7yoilsho	2208	9	.	.	.
cord-006229-7yoilsho	2209	1	In	in	IN
cord-006229-7yoilsho	2209	2	comparison	comparison	NN
cord-006229-7yoilsho	2209	3	,	,	,
cord-006229-7yoilsho	2209	4	TF	TF	NNP
cord-006229-7yoilsho	2209	5	mRNA	mRNA	NNP
cord-006229-7yoilsho	2209	6	and	and	CC
cord-006229-7yoilsho	2209	7	protein	protein	NN
cord-006229-7yoilsho	2209	8	were	be	VBD
cord-006229-7yoilsho	2209	9	only	only	RB
cord-006229-7yoilsho	2209	10	marginally	marginally	RB
cord-006229-7yoilsho	2209	11	elevated	elevated	JJ
cord-006229-7yoilsho	2209	12	in	in	IN
cord-006229-7yoilsho	2209	13	non	non	JJ
cord-006229-7yoilsho	2209	14	-	-	JJ
cord-006229-7yoilsho	2209	15	differentiated	differentiated	JJ
cord-006229-7yoilsho	2209	16	THP1	THP1	NNP
cord-006229-7yoilsho	2209	17	monocytes	monocyte	NNS
cord-006229-7yoilsho	2209	18	and	and	CC
cord-006229-7yoilsho	2209	19	TM	TM	NNP
cord-006229-7yoilsho	2209	20	was	be	VBD
cord-006229-7yoilsho	2209	21	not	not	RB
cord-006229-7yoilsho	2209	22	regulated	regulate	VBN
cord-006229-7yoilsho	2209	23	by	by	IN
cord-006229-7yoilsho	2209	24	S1P.	S1P.	NNP
cord-006229-7yoilsho	2210	1	After	after	IN
cord-006229-7yoilsho	2210	2	differentiation	differentiation	NN
cord-006229-7yoilsho	2210	3	of	of	IN
cord-006229-7yoilsho	2210	4	cultured	cultured	JJ
cord-006229-7yoilsho	2210	5	monocytic	monocytic	JJ
cord-006229-7yoilsho	2210	6	cells	cell	NNS
cord-006229-7yoilsho	2210	7	with	with	IN
cord-006229-7yoilsho	2210	8	PMA	PMA	NNP
cord-006229-7yoilsho	2210	9	into	into	IN
cord-006229-7yoilsho	2210	10	adhesive	adhesive	JJ
cord-006229-7yoilsho	2210	11	macrophage	macrophage	NN
cord-006229-7yoilsho	2210	12	-	-	HYPH
cord-006229-7yoilsho	2210	13	like	like	JJ
cord-006229-7yoilsho	2210	14	cells	cell	NNS
cord-006229-7yoilsho	2210	15	,	,	,
cord-006229-7yoilsho	2210	16	incubation	incubation	NN
cord-006229-7yoilsho	2210	17	with	with	IN
cord-006229-7yoilsho	2210	18	S1P	s1p	CD
cord-006229-7yoilsho	2210	19	resulted	result	VBD
cord-006229-7yoilsho	2210	20	in	in	IN
cord-006229-7yoilsho	2210	21	a	a	DT
cord-006229-7yoilsho	2210	22	time-(1	time-(1	NNP
cord-006229-7yoilsho	2210	23	to	to	IN
cord-006229-7yoilsho	2210	24	24	24	CD
cord-006229-7yoilsho	2210	25	h	h	NN
cord-006229-7yoilsho	2210	26	)	)	-RRB-
cord-006229-7yoilsho	2210	27	and	and	CC
cord-006229-7yoilsho	2210	28	concentration	concentration	NN
cord-006229-7yoilsho	2210	29	-	-	HYPH
cord-006229-7yoilsho	2210	30	dependent	dependent	JJ
cord-006229-7yoilsho	2210	31	(	(	-LRB-
cord-006229-7yoilsho	2210	32	0.1	0.1	CD
cord-006229-7yoilsho	2210	33	to	to	TO
cord-006229-7yoilsho	2210	34	10	10	CD
cord-006229-7yoilsho	2210	35	µM	µm	NN
cord-006229-7yoilsho	2210	36	)	)	-RRB-
cord-006229-7yoilsho	2211	1	significant	significant	JJ
cord-006229-7yoilsho	2211	2	upregulation	upregulation	NN
cord-006229-7yoilsho	2211	3	of	of	IN
cord-006229-7yoilsho	2211	4	TF	TF	NNP
cord-006229-7yoilsho	2211	5	expression	expression	NN
cord-006229-7yoilsho	2211	6	within	within	IN
cord-006229-7yoilsho	2211	7	3	3	CD
cord-006229-7yoilsho	2211	8	to	to	IN
cord-006229-7yoilsho	2211	9	6	6	CD
cord-006229-7yoilsho	2211	10	h	h	NN
cord-006229-7yoilsho	2211	11	of	of	IN
cord-006229-7yoilsho	2211	12	incubation	incubation	NN
cord-006229-7yoilsho	2211	13	.	.	.
cord-006229-7yoilsho	2212	1	Conversely	conversely	RB
cord-006229-7yoilsho	2212	2	,	,	,
cord-006229-7yoilsho	2212	3	PAR2	par2	JJ
cord-006229-7yoilsho	2212	4	total	total	JJ
cord-006229-7yoilsho	2212	5	protein	protein	NN
cord-006229-7yoilsho	2212	6	expression	expression	NN
cord-006229-7yoilsho	2212	7	was	be	VBD
cord-006229-7yoilsho	2212	8	reduced	reduce	VBN
cord-006229-7yoilsho	2212	9	by	by	IN
cord-006229-7yoilsho	2212	10	about	about	RB
cord-006229-7yoilsho	2212	11	50	50	CD
cord-006229-7yoilsho	2212	12	%	%	NN
cord-006229-7yoilsho	2212	13	after	after	IN
cord-006229-7yoilsho	2212	14	24	24	CD
cord-006229-7yoilsho	2212	15	h	h	NN
cord-006229-7yoilsho	2212	16	S1P	s1p	NN
cord-006229-7yoilsho	2212	17	incubation	incubation	NN
cord-006229-7yoilsho	2212	18	.	.	.
cord-006229-7yoilsho	2213	1	The	the	DT
cord-006229-7yoilsho	2213	2	expression	expression	NN
cord-006229-7yoilsho	2213	3	of	of	IN
cord-006229-7yoilsho	2213	4	TM	TM	NNP
cord-006229-7yoilsho	2213	5	was	be	VBD
cord-006229-7yoilsho	2213	6	again	again	RB
cord-006229-7yoilsho	2213	7	not	not	RB
cord-006229-7yoilsho	2213	8	affected	affect	VBN
cord-006229-7yoilsho	2213	9	.	.	.
cord-006229-7yoilsho	2214	1	The	the	DT
cord-006229-7yoilsho	2214	2	generation	generation	NN
cord-006229-7yoilsho	2214	3	of	of	IN
cord-006229-7yoilsho	2214	4	thrombin	thrombin	NN
cord-006229-7yoilsho	2214	5	in	in	IN
cord-006229-7yoilsho	2214	6	platelet	platelet	NN
cord-006229-7yoilsho	2214	7	-	-	HYPH
cord-006229-7yoilsho	2214	8	rich	rich	JJ
cord-006229-7yoilsho	2214	9	plasma	plasma	NN
cord-006229-7yoilsho	2214	10	was	be	VBD
cord-006229-7yoilsho	2214	11	determined	determine	VBN
cord-006229-7yoilsho	2214	12	using	use	VBG
cord-006229-7yoilsho	2214	13	PMA	PMA	NNP
cord-006229-7yoilsho	2214	14	-	-	HYPH
cord-006229-7yoilsho	2214	15	differentiated	differentiate	VBN
cord-006229-7yoilsho	2214	16	THP1	THP1	NNP
cord-006229-7yoilsho	2214	17	cells	cell	NNS
cord-006229-7yoilsho	2214	18	as	as	IN
cord-006229-7yoilsho	2214	19	TF	TF	NNP
cord-006229-7yoilsho	2214	20	source	source	NN
cord-006229-7yoilsho	2214	21	.	.	.
cord-006229-7yoilsho	2215	1	Timedependent	timedependent	JJ
cord-006229-7yoilsho	2215	2	incubation	incubation	NN
cord-006229-7yoilsho	2215	3	with	with	IN
cord-006229-7yoilsho	2215	4	S1P	s1p	NN
cord-006229-7yoilsho	2215	5	(	(	-LRB-
cord-006229-7yoilsho	2215	6	1	1	CD
cord-006229-7yoilsho	2215	7	µM	µm	CD
cord-006229-7yoilsho	2215	8	)	)	-RRB-
cord-006229-7yoilsho	2215	9	in	in	IN
cord-006229-7yoilsho	2215	10	differentiated	differentiated	JJ
cord-006229-7yoilsho	2215	11	monocytes	monocyte	NNS
cord-006229-7yoilsho	2215	12	shortened	shorten	VBD
cord-006229-7yoilsho	2215	13	the	the	DT
cord-006229-7yoilsho	2215	14	time	time	NN
cord-006229-7yoilsho	2215	15	to	to	IN
cord-006229-7yoilsho	2215	16	the	the	DT
cord-006229-7yoilsho	2215	17	onset	onset	NN
cord-006229-7yoilsho	2215	18	(	(	-LRB-
cord-006229-7yoilsho	2215	19	lag	lag	NN
cord-006229-7yoilsho	2215	20	time	time	NN
cord-006229-7yoilsho	2215	21	)	)	-RRB-
cord-006229-7yoilsho	2215	22	of	of	IN
cord-006229-7yoilsho	2215	23	thrombin	thrombin	JJ
cord-006229-7yoilsho	2215	24	generation	generation	NN
cord-006229-7yoilsho	2215	25	in	in	IN
cord-006229-7yoilsho	2215	26	plasma	plasma	NN
cord-006229-7yoilsho	2215	27	from	from	IN
cord-006229-7yoilsho	2215	28	8.0±1.6	8.0±1.6	NNS
cord-006229-7yoilsho	2215	29	to	to	IN
cord-006229-7yoilsho	2215	30	6.5±1.4	6.5±1.4	CD
cord-006229-7yoilsho	2215	31	min	min	NN
cord-006229-7yoilsho	2215	32	and	and	CC
cord-006229-7yoilsho	2215	33	elevated	elevate	VBD
cord-006229-7yoilsho	2215	34	total	total	NN
cord-006229-7yoilsho	2215	35	the	the	DT
cord-006229-7yoilsho	2215	36	thrombin	thrombin	JJ
cord-006229-7yoilsho	2215	37	generation	generation	NN
cord-006229-7yoilsho	2215	38	capacity	capacity	NN
cord-006229-7yoilsho	2215	39	from	from	IN
cord-006229-7yoilsho	2215	40	814±130	814±130	CD
cord-006229-7yoilsho	2215	41	to	to	IN
cord-006229-7yoilsho	2215	42	1286±129	1286±129	CD
cord-006229-7yoilsho	2216	1	nM.	nM.	NNP
cord-006229-7yoilsho	2216	2	Peak	Peak	NNP
cord-006229-7yoilsho	2216	3	thrombin	thrombin	JJ
cord-006229-7yoilsho	2216	4	formation	formation	NN
cord-006229-7yoilsho	2216	5	was	be	VBD
cord-006229-7yoilsho	2216	6	elevated	elevate	VBN
cord-006229-7yoilsho	2216	7	from	from	IN
cord-006229-7yoilsho	2216	8	66±31	66±31	NNP
cord-006229-7yoilsho	2216	9	to	to	IN
cord-006229-7yoilsho	2216	10	130±30	130±30	CD
cord-006229-7yoilsho	2216	11	nM	nM	NNP
cord-006229-7yoilsho	2216	12	/	/	SYM
cord-006229-7yoilsho	2216	13	min	min	NNP
cord-006229-7yoilsho	2216	14	(	(	-LRB-
cord-006229-7yoilsho	2216	15	control	control	NN
cord-006229-7yoilsho	2216	16	versus	versus	IN
cord-006229-7yoilsho	2216	17	S1P	s1p	NN
cord-006229-7yoilsho	2216	18	for	for	IN
cord-006229-7yoilsho	2216	19	6h	6h	CD
cord-006229-7yoilsho	2216	20	,	,	,
cord-006229-7yoilsho	2216	21	mean±SD	mean±SD	NNP
cord-006229-7yoilsho	2216	22	,	,	,
cord-006229-7yoilsho	2216	23	n=5	n=5	JJ
cord-006229-7yoilsho	2216	24	,	,	,
cord-006229-7yoilsho	2216	25	respectively	respectively	RB
cord-006229-7yoilsho	2216	26	)	)	-RRB-
cord-006229-7yoilsho	2216	27	.	.	.
cord-006229-7yoilsho	2217	1	These	these	DT
cord-006229-7yoilsho	2217	2	data	datum	NNS
cord-006229-7yoilsho	2217	3	suggest	suggest	VBP
cord-006229-7yoilsho	2217	4	that	that	IN
cord-006229-7yoilsho	2217	5	S1P	s1p	NN
cord-006229-7yoilsho	2217	6	induces	induce	VBZ
cord-006229-7yoilsho	2217	7	an	an	DT
cord-006229-7yoilsho	2217	8	enhanced	enhanced	JJ
cord-006229-7yoilsho	2217	9	expression	expression	NN
cord-006229-7yoilsho	2217	10	of	of	IN
cord-006229-7yoilsho	2217	11	PAR2	PAR2	NNP
cord-006229-7yoilsho	2217	12	in	in	IN
cord-006229-7yoilsho	2217	13	undifferentiated	undifferentiated	JJ
cord-006229-7yoilsho	2217	14	human	human	JJ
cord-006229-7yoilsho	2217	15	monocytes	monocyte	NNS
cord-006229-7yoilsho	2217	16	while	while	IN
cord-006229-7yoilsho	2217	17	TF	TF	NNP
cord-006229-7yoilsho	2217	18	and	and	CC
cord-006229-7yoilsho	2217	19	TM	TM	NNP
cord-006229-7yoilsho	2217	20	are	be	VBP
cord-006229-7yoilsho	2217	21	not	not	RB
cord-006229-7yoilsho	2217	22	regulated	regulate	VBN
cord-006229-7yoilsho	2217	23	.	.	.
cord-006229-7yoilsho	2218	1	In	in	IN
cord-006229-7yoilsho	2218	2	differentiated	differentiated	JJ
cord-006229-7yoilsho	2218	3	monocytes	monocyte	NNS
cord-006229-7yoilsho	2218	4	/	/	SYM
cord-006229-7yoilsho	2218	5	macrophages	macrophage	NNS
cord-006229-7yoilsho	2218	6	,	,	,
cord-006229-7yoilsho	2218	7	S1P	s1p	NN
cord-006229-7yoilsho	2218	8	does	do	VBZ
cord-006229-7yoilsho	2218	9	upregulate	upregulate	VB
cord-006229-7yoilsho	2218	10	TF	TF	NNP
cord-006229-7yoilsho	2218	11	expression	expression	NN
cord-006229-7yoilsho	2218	12	but	but	CC
cord-006229-7yoilsho	2218	13	attenuates	attenuate	VBZ
cord-006229-7yoilsho	2218	14	PAR2	par2	JJ
cord-006229-7yoilsho	2218	15	levels	level	NNS
cord-006229-7yoilsho	2218	16	.	.	.
cord-006229-7yoilsho	2219	1	Since	since	IN
cord-006229-7yoilsho	2219	2	PAR2	PAR2	NNP
cord-006229-7yoilsho	2219	3	is	be	VBZ
cord-006229-7yoilsho	2219	4	involved	involve	VBN
cord-006229-7yoilsho	2219	5	in	in	IN
cord-006229-7yoilsho	2219	6	regulation	regulation	NN
cord-006229-7yoilsho	2219	7	cell	cell	NN
cord-006229-7yoilsho	2219	8	migration	migration	NN
cord-006229-7yoilsho	2219	9	,	,	,
cord-006229-7yoilsho	2219	10	S1P	s1p	CD
cord-006229-7yoilsho	2219	11	may	may	MD
cord-006229-7yoilsho	2219	12	stimulate	stimulate	VB
cord-006229-7yoilsho	2219	13	a	a	DT
cord-006229-7yoilsho	2219	14	phenotypic	phenotypic	NN
cord-006229-7yoilsho	2219	15	switching	switch	VBG
cord-006229-7yoilsho	2219	16	from	from	IN
cord-006229-7yoilsho	2219	17	a	a	DT
cord-006229-7yoilsho	2219	18	migratory	migratory	NN
cord-006229-7yoilsho	2219	19	to	to	IN
cord-006229-7yoilsho	2219	20	a	a	DT
cord-006229-7yoilsho	2219	21	procoagulant	procoagulant	JJ
cord-006229-7yoilsho	2219	22	phenotype	phenotype	NN
cord-006229-7yoilsho	2219	23	during	during	IN
cord-006229-7yoilsho	2219	24	differentiation	differentiation	NN
cord-006229-7yoilsho	2219	25	of	of	IN
cord-006229-7yoilsho	2219	26	monocytes	monocyte	NNS
cord-006229-7yoilsho	2219	27	into	into	IN
cord-006229-7yoilsho	2219	28	macrophages	macrophage	NNS
cord-006229-7yoilsho	2219	29	.	.	.
cord-006229-7yoilsho	2220	1	The	the	DT
cord-006229-7yoilsho	2220	2	pro	pro	JJ
cord-006229-7yoilsho	2220	3	-	-	JJ
cord-006229-7yoilsho	2220	4	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	2220	5	cytokine	cytokine	NN
cord-006229-7yoilsho	2220	6	interleukin-6	interleukin-6	NNP
cord-006229-7yoilsho	2220	7	(	(	-LRB-
cord-006229-7yoilsho	2220	8	IL-6	IL-6	NNP
cord-006229-7yoilsho	2220	9	)	)	-RRB-
cord-006229-7yoilsho	2220	10	plays	play	VBZ
cord-006229-7yoilsho	2220	11	an	an	DT
cord-006229-7yoilsho	2220	12	important	important	JJ
cord-006229-7yoilsho	2220	13	role	role	NN
cord-006229-7yoilsho	2220	14	in	in	IN
cord-006229-7yoilsho	2220	15	vascular	vascular	JJ
cord-006229-7yoilsho	2220	16	inflammation	inflammation	NN
cord-006229-7yoilsho	2220	17	.	.	.
cord-006229-7yoilsho	2221	1	Coagulation	coagulation	NN
cord-006229-7yoilsho	2221	2	factors	factor	NNS
cord-006229-7yoilsho	2221	3	such	such	JJ
cord-006229-7yoilsho	2221	4	as	as	IN
cord-006229-7yoilsho	2221	5	the	the	DT
cord-006229-7yoilsho	2221	6	activated	activate	VBN
cord-006229-7yoilsho	2221	7	factor	factor	NN
cord-006229-7yoilsho	2221	8	-	-	HYPH
cord-006229-7yoilsho	2221	9	X	x	NN
cord-006229-7yoilsho	2221	10	(	(	-LRB-
cord-006229-7yoilsho	2221	11	FXa	FXa	NNS
cord-006229-7yoilsho	2221	12	)	)	-RRB-
cord-006229-7yoilsho	2221	13	may	may	MD
cord-006229-7yoilsho	2221	14	regulate	regulate	VB
cord-006229-7yoilsho	2221	15	local	local	JJ
cord-006229-7yoilsho	2221	16	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	2221	17	responses	response	NNS
cord-006229-7yoilsho	2221	18	of	of	IN
cord-006229-7yoilsho	2221	19	the	the	DT
cord-006229-7yoilsho	2221	20	vessel	vessel	NN
cord-006229-7yoilsho	2221	21	wall	wall	NN
cord-006229-7yoilsho	2221	22	.	.	.
cord-006229-7yoilsho	2222	1	In	in	IN
cord-006229-7yoilsho	2222	2	this	this	DT
cord-006229-7yoilsho	2222	3	study	study	NN
cord-006229-7yoilsho	2222	4	we	-PRON-	PRP
cord-006229-7yoilsho	2222	5	investigated	investigate	VBD
cord-006229-7yoilsho	2222	6	whether	whether	IN
cord-006229-7yoilsho	2222	7	FXa	FXa	NNS
cord-006229-7yoilsho	2222	8	regulates	regulate	VBZ
cord-006229-7yoilsho	2222	9	IL-6	IL-6	NNP
cord-006229-7yoilsho	2222	10	expression	expression	NN
cord-006229-7yoilsho	2222	11	and	and	CC
cord-006229-7yoilsho	2222	12	secretion	secretion	NN
cord-006229-7yoilsho	2222	13	in	in	IN
cord-006229-7yoilsho	2222	14	human	human	JJ
cord-006229-7yoilsho	2222	15	vascular	vascular	JJ
cord-006229-7yoilsho	2222	16	smooth	smooth	JJ
cord-006229-7yoilsho	2222	17	muscle	muscle	NN
cord-006229-7yoilsho	2222	18	cells	cell	NNS
cord-006229-7yoilsho	2222	19	(	(	-LRB-
cord-006229-7yoilsho	2222	20	SMC	SMC	NNP
cord-006229-7yoilsho	2222	21	)	)	-RRB-
cord-006229-7yoilsho	2222	22	as	as	RB
cord-006229-7yoilsho	2222	23	well	well	RB
cord-006229-7yoilsho	2222	24	as	as	IN
cord-006229-7yoilsho	2222	25	in	in	IN
cord-006229-7yoilsho	2222	26	failed	fail	VBN
cord-006229-7yoilsho	2222	27	thrombosed	thrombosed	JJ
cord-006229-7yoilsho	2222	28	vein	vein	NN
cord-006229-7yoilsho	2222	29	grafts	graft	NNS
cord-006229-7yoilsho	2222	30	.	.	.
cord-006229-7yoilsho	2223	1	Also	also	RB
cord-006229-7yoilsho	2223	2	,	,	,
cord-006229-7yoilsho	2223	3	we	-PRON-	PRP
cord-006229-7yoilsho	2223	4	analysed	analyse	VBD
cord-006229-7yoilsho	2223	5	its	-PRON-	PRP$
cord-006229-7yoilsho	2223	6	possible	possible	JJ
cord-006229-7yoilsho	2223	7	prothrombotic	prothrombotic	JJ
cord-006229-7yoilsho	2223	8	impact	impact	NN
cord-006229-7yoilsho	2223	9	on	on	IN
cord-006229-7yoilsho	2223	10	monocytes	monocyte	NNS
cord-006229-7yoilsho	2223	11	.	.	.
cord-006229-7yoilsho	2224	1	IL-6	IL-6	NNP
cord-006229-7yoilsho	2224	2	mRNA	mRNA	NNP
cord-006229-7yoilsho	2224	3	expression	expression	NN
cord-006229-7yoilsho	2224	4	was	be	VBD
cord-006229-7yoilsho	2224	5	determined	determine	VBN
cord-006229-7yoilsho	2224	6	in	in	IN
cord-006229-7yoilsho	2224	7	primary	primary	JJ
cord-006229-7yoilsho	2224	8	human	human	JJ
cord-006229-7yoilsho	2224	9	saphenous	saphenous	JJ
cord-006229-7yoilsho	2224	10	vein	vein	NN
cord-006229-7yoilsho	2224	11	SMC	SMC	NNP
cord-006229-7yoilsho	2224	12	by	by	IN
cord-006229-7yoilsho	2225	1	Taqman	Taqman	NNP
cord-006229-7yoilsho	2225	2	®	®	POS
cord-006229-7yoilsho	2225	3	real	real	JJ
cord-006229-7yoilsho	2225	4	-	-	HYPH
cord-006229-7yoilsho	2225	5	time	time	NN
cord-006229-7yoilsho	2225	6	PCR	PCR	NNP
cord-006229-7yoilsho	2225	7	.	.	.
cord-006229-7yoilsho	2226	1	Secretion	secretion	NN
cord-006229-7yoilsho	2226	2	to	to	IN
cord-006229-7yoilsho	2226	3	the	the	DT
cord-006229-7yoilsho	2226	4	cell	cell	NN
cord-006229-7yoilsho	2226	5	culture	culture	NN
cord-006229-7yoilsho	2226	6	media	medium	NNS
cord-006229-7yoilsho	2226	7	was	be	VBD
cord-006229-7yoilsho	2226	8	measured	measure	VBN
cord-006229-7yoilsho	2226	9	by	by	IN
cord-006229-7yoilsho	2226	10	ELISA	ELISA	NNP
cord-006229-7yoilsho	2226	11	.	.	.
cord-006229-7yoilsho	2227	1	Tissue	tissue	NN
cord-006229-7yoilsho	2227	2	Factor	factor	NN
cord-006229-7yoilsho	2227	3	(	(	-LRB-
cord-006229-7yoilsho	2227	4	TF	TF	NNP
cord-006229-7yoilsho	2227	5	)	)	-RRB-
cord-006229-7yoilsho	2227	6	expression	expression	NN
cord-006229-7yoilsho	2227	7	in	in	IN
cord-006229-7yoilsho	2227	8	monocytic	monocytic	NNP
cord-006229-7yoilsho	2227	9	THP-1	THP-1	NNP
cord-006229-7yoilsho	2227	10	cells	cell	NNS
cord-006229-7yoilsho	2227	11	was	be	VBD
cord-006229-7yoilsho	2227	12	determined	determine	VBN
cord-006229-7yoilsho	2227	13	by	by	IN
cord-006229-7yoilsho	2227	14	Western	western	JJ
cord-006229-7yoilsho	2227	15	Blot	blot	NN
cord-006229-7yoilsho	2227	16	.	.	.
cord-006229-7yoilsho	2228	1	Immunostainings	Immunostainings	NNP
cord-006229-7yoilsho	2228	2	for	for	IN
cord-006229-7yoilsho	2228	3	IL-6	IL-6	NNP
cord-006229-7yoilsho	2228	4	and	and	CC
cord-006229-7yoilsho	2228	5	the	the	DT
cord-006229-7yoilsho	2228	6	SMC	SMC	NNP
cord-006229-7yoilsho	2228	7	marker	marker	NN
cord-006229-7yoilsho	2228	8	smoothelin	smoothelin	NNP
cord-006229-7yoilsho	2228	9	were	be	VBD
cord-006229-7yoilsho	2228	10	performed	perform	VBN
cord-006229-7yoilsho	2228	11	on	on	IN
cord-006229-7yoilsho	2228	12	paraffin	paraffin	NN
cord-006229-7yoilsho	2228	13	embedded	embed	VBN
cord-006229-7yoilsho	2228	14	tissue	tissue	NN
cord-006229-7yoilsho	2228	15	sections	section	NNS
cord-006229-7yoilsho	2228	16	from	from	IN
cord-006229-7yoilsho	2228	17	failed	fail	VBN
cord-006229-7yoilsho	2228	18	thrombosed	thrombosed	JJ
cord-006229-7yoilsho	2228	19	vein	vein	NN
cord-006229-7yoilsho	2228	20	grafts	graft	NNS
cord-006229-7yoilsho	2228	21	and	and	CC
cord-006229-7yoilsho	2228	22	control	control	NN
cord-006229-7yoilsho	2228	23	veins	vein	NNS
cord-006229-7yoilsho	2228	24	.	.	.
cord-006229-7yoilsho	2229	1	Incubation	incubation	NN
cord-006229-7yoilsho	2229	2	of	of	IN
cord-006229-7yoilsho	2229	3	cultured	cultured	JJ
cord-006229-7yoilsho	2229	4	human	human	JJ
cord-006229-7yoilsho	2229	5	venous	venous	JJ
cord-006229-7yoilsho	2229	6	SMC	SMC	NNP
cord-006229-7yoilsho	2229	7	with	with	IN
cord-006229-7yoilsho	2229	8	FXa	FXa	NNS
cord-006229-7yoilsho	2229	9	(	(	-LRB-
cord-006229-7yoilsho	2229	10	30	30	CD
cord-006229-7yoilsho	2229	11	nM	nm	NN
cord-006229-7yoilsho	2229	12	)	)	-RRB-
cord-006229-7yoilsho	2229	13	induced	induce	VBD
cord-006229-7yoilsho	2229	14	a	a	DT
cord-006229-7yoilsho	2229	15	time	time	NN
cord-006229-7yoilsho	2229	16	-	-	HYPH
cord-006229-7yoilsho	2229	17	dependent	dependent	JJ
cord-006229-7yoilsho	2229	18	(	(	-LRB-
cord-006229-7yoilsho	2229	19	3	3	CD
cord-006229-7yoilsho	2229	20	-16	-16	NN
cord-006229-7yoilsho	2229	21	h	h	NN
cord-006229-7yoilsho	2229	22	)	)	-RRB-
cord-006229-7yoilsho	2229	23	increase	increase	NN
cord-006229-7yoilsho	2229	24	in	in	IN
cord-006229-7yoilsho	2229	25	IL-6	IL-6	NNP
cord-006229-7yoilsho	2229	26	mRNA	mRNA	NNP
cord-006229-7yoilsho	2229	27	expression	expression	NN
cord-006229-7yoilsho	2229	28	.	.	.
cord-006229-7yoilsho	2230	1	Maximum	maximum	JJ
cord-006229-7yoilsho	2230	2	expression	expression	NN
cord-006229-7yoilsho	2230	3	was	be	VBD
cord-006229-7yoilsho	2230	4	observed	observe	VBN
cord-006229-7yoilsho	2230	5	within	within	IN
cord-006229-7yoilsho	2230	6	6	6	CD
cord-006229-7yoilsho	2230	7	h	h	NN
cord-006229-7yoilsho	2230	8	to	to	IN
cord-006229-7yoilsho	2230	9	a	a	DT
cord-006229-7yoilsho	2230	10	7.2±3.3	7.2±3.3	NN
cord-006229-7yoilsho	2230	11	fold	fold	JJ
cord-006229-7yoilsho	2230	12	increase	increase	NN
cord-006229-7yoilsho	2230	13	(	(	-LRB-
cord-006229-7yoilsho	2230	14	mean±SD	mean±SD	NNP
cord-006229-7yoilsho	2230	15	,	,	,
cord-006229-7yoilsho	2230	16	n=5	n=5	JJ
cord-006229-7yoilsho	2230	17	,	,	,
cord-006229-7yoilsho	2230	18	p<0.05	p<0.05	CD
cord-006229-7yoilsho	2230	19	)	)	-RRB-
cord-006229-7yoilsho	2230	20	.	.	.
cord-006229-7yoilsho	2231	1	Incubation	incubation	NN
cord-006229-7yoilsho	2231	2	with	with	IN
cord-006229-7yoilsho	2231	3	an	an	DT
cord-006229-7yoilsho	2231	4	inhibitor	inhibitor	NN
cord-006229-7yoilsho	2231	5	of	of	IN
cord-006229-7yoilsho	2231	6	p38	p38	NNP
cord-006229-7yoilsho	2231	7	MAP	MAP	NNP
cord-006229-7yoilsho	2231	8	kinase	kinase	NN
cord-006229-7yoilsho	2231	9	(	(	-LRB-
cord-006229-7yoilsho	2231	10	SB203580	sb203580	NN
cord-006229-7yoilsho	2231	11	,	,	,
cord-006229-7yoilsho	2231	12	10	10	CD
cord-006229-7yoilsho	2231	13	µM	µM	NNS
cord-006229-7yoilsho	2231	14	)	)	-RRB-
cord-006229-7yoilsho	2231	15	or	or	CC
cord-006229-7yoilsho	2231	16	PI3	PI3	NNP
cord-006229-7yoilsho	2231	17	K	K	NNP
cord-006229-7yoilsho	2231	18	(	(	-LRB-
cord-006229-7yoilsho	2231	19	LY294002	LY294002	NNP
cord-006229-7yoilsho	2231	20	,	,	,
cord-006229-7yoilsho	2231	21	10	10	CD
cord-006229-7yoilsho	2231	22	µM	µm	CD
cord-006229-7yoilsho	2231	23	)	)	-RRB-
cord-006229-7yoilsho	2231	24	significantly	significantly	RB
cord-006229-7yoilsho	2231	25	attenuated	attenuate	VBN
cord-006229-7yoilsho	2231	26	FXa	FXa	NNS
cord-006229-7yoilsho	2231	27	-	-	HYPH
cord-006229-7yoilsho	2231	28	induced	induce	VBN
cord-006229-7yoilsho	2231	29	IL-6	IL-6	NNP
cord-006229-7yoilsho	2231	30	mRNA	mRNA	NNP
cord-006229-7yoilsho	2231	31	expression	expression	NN
cord-006229-7yoilsho	2231	32	(	(	-LRB-
cord-006229-7yoilsho	2231	33	n=5	n=5	RB
cord-006229-7yoilsho	2231	34	)	)	-RRB-
cord-006229-7yoilsho	2231	35	.	.	.
cord-006229-7yoilsho	2232	1	Inhibition	inhibition	NN
cord-006229-7yoilsho	2232	2	of	of	IN
cord-006229-7yoilsho	2232	3	p42/44	p42/44	NNP
cord-006229-7yoilsho	2232	4	MAPK	MAPK	NNP
cord-006229-7yoilsho	2232	5	,	,	,
cord-006229-7yoilsho	2232	6	Rho	rho	NN
cord-006229-7yoilsho	2232	7	kinase	kinase	NN
cord-006229-7yoilsho	2232	8	or	or	CC
cord-006229-7yoilsho	2232	9	NF	NF	NNP
cord-006229-7yoilsho	2232	10	-	-	HYPH
cord-006229-7yoilsho	2232	11	kB	kB	NNP
cord-006229-7yoilsho	2232	12	had	have	VBD
cord-006229-7yoilsho	2232	13	no	no	DT
cord-006229-7yoilsho	2232	14	significant	significant	JJ
cord-006229-7yoilsho	2232	15	effect	effect	NN
cord-006229-7yoilsho	2232	16	.	.	.
cord-006229-7yoilsho	2233	1	Stimulation	stimulation	NN
cord-006229-7yoilsho	2233	2	with	with	IN
cord-006229-7yoilsho	2233	3	FXa	FXa	NNS
cord-006229-7yoilsho	2233	4	for	for	IN
cord-006229-7yoilsho	2233	5	24h	24h	NNS
cord-006229-7yoilsho	2233	6	resulted	result	VBD
cord-006229-7yoilsho	2233	7	in	in	IN
cord-006229-7yoilsho	2233	8	a	a	DT
cord-006229-7yoilsho	2233	9	markedly	markedly	RB
cord-006229-7yoilsho	2233	10	increased	increase	VBN
cord-006229-7yoilsho	2233	11	IL-6	IL-6	NNP
cord-006229-7yoilsho	2233	12	secretion	secretion	NN
cord-006229-7yoilsho	2233	13	into	into	IN
cord-006229-7yoilsho	2233	14	the	the	DT
cord-006229-7yoilsho	2233	15	SMC	SMC	NNP
cord-006229-7yoilsho	2233	16	culture	culture	NN
cord-006229-7yoilsho	2233	17	media	medium	NNS
cord-006229-7yoilsho	2233	18	from	from	IN
cord-006229-7yoilsho	2233	19	0.6±0.2	0.6±0.2	CD
cord-006229-7yoilsho	2233	20	to	to	IN
cord-006229-7yoilsho	2233	21	1.1±0.3	1.1±0.3	NNP
cord-006229-7yoilsho	2233	22	ng	ng	NNP
cord-006229-7yoilsho	2233	23	/	/	SYM
cord-006229-7yoilsho	2233	24	ml	ml	NN
cord-006229-7yoilsho	2234	1	(	(	-LRB-
cord-006229-7yoilsho	2234	2	p<0.5	p<0.5	NNP
cord-006229-7yoilsho	2234	3	,	,	,
cord-006229-7yoilsho	2234	4	n=4	n=4	JJ
cord-006229-7yoilsho	2234	5	)	)	-RRB-
cord-006229-7yoilsho	2234	6	.	.	.
cord-006229-7yoilsho	2235	1	Stimulation	stimulation	NN
cord-006229-7yoilsho	2235	2	of	of	IN
cord-006229-7yoilsho	2235	3	THP-1	THP-1	NNP
cord-006229-7yoilsho	2235	4	cells	cell	NNS
cord-006229-7yoilsho	2235	5	with	with	IN
cord-006229-7yoilsho	2235	6	IL-6	IL-6	NNP
cord-006229-7yoilsho	2235	7	(	(	-LRB-
cord-006229-7yoilsho	2235	8	1	1	CD
cord-006229-7yoilsho	2235	9	ng	ng	NN
cord-006229-7yoilsho	2235	10	/	/	SYM
cord-006229-7yoilsho	2235	11	ml	ml	NN
cord-006229-7yoilsho	2235	12	)	)	-RRB-
cord-006229-7yoilsho	2235	13	induced	induce	VBD
cord-006229-7yoilsho	2235	14	a	a	DT
cord-006229-7yoilsho	2235	15	time	time	NN
cord-006229-7yoilsho	2235	16	dependent	dependent	JJ
cord-006229-7yoilsho	2235	17	(	(	-LRB-
cord-006229-7yoilsho	2235	18	6	6	CD
cord-006229-7yoilsho	2235	19	-24	-24	NN
cord-006229-7yoilsho	2235	20	h	h	NN
cord-006229-7yoilsho	2235	21	)	)	-RRB-
cord-006229-7yoilsho	2235	22	increase	increase	NN
cord-006229-7yoilsho	2235	23	of	of	IN
cord-006229-7yoilsho	2235	24	up	up	IN
cord-006229-7yoilsho	2235	25	to	to	IN
cord-006229-7yoilsho	2235	26	2.1±0.6	2.1±0.6	CD
cord-006229-7yoilsho	2235	27	fold	fold	VB
cord-006229-7yoilsho	2235	28	(	(	-LRB-
cord-006229-7yoilsho	2235	29	p<0.05	p<0.05	XX
cord-006229-7yoilsho	2235	30	,	,	,
cord-006229-7yoilsho	2235	31	n=5	n=5	JJ
cord-006229-7yoilsho	2235	32	)	)	-RRB-
cord-006229-7yoilsho	2235	33	in	in	IN
cord-006229-7yoilsho	2235	34	TF	TF	NNP
cord-006229-7yoilsho	2235	35	protein	protein	NN
cord-006229-7yoilsho	2235	36	expression	expression	NN
cord-006229-7yoilsho	2235	37	.	.	.
cord-006229-7yoilsho	2236	1	Immunostainings	immunostaining	NNS
cord-006229-7yoilsho	2236	2	of	of	IN
cord-006229-7yoilsho	2236	3	tissue	tissue	NN
cord-006229-7yoilsho	2236	4	sample	sample	NN
cord-006229-7yoilsho	2236	5	of	of	IN
cord-006229-7yoilsho	2236	6	failed	fail	VBN
cord-006229-7yoilsho	2236	7	vein	vein	NN
cord-006229-7yoilsho	2236	8	grafts	graft	NNS
cord-006229-7yoilsho	2236	9	revealed	reveal	VBD
cord-006229-7yoilsho	2236	10	enhanced	enhance	VBN
cord-006229-7yoilsho	2236	11	IL-6	IL-6	NNP
cord-006229-7yoilsho	2236	12	expression	expression	NN
cord-006229-7yoilsho	2236	13	in	in	IN
cord-006229-7yoilsho	2236	14	SMC	SMC	NNP
cord-006229-7yoilsho	2236	15	-	-	HYPH
cord-006229-7yoilsho	2236	16	rich	rich	JJ
cord-006229-7yoilsho	2236	17	regions	region	NNS
cord-006229-7yoilsho	2236	18	in	in	IN
cord-006229-7yoilsho	2236	19	vessel	vessel	NN
cord-006229-7yoilsho	2236	20	walls	wall	NNS
cord-006229-7yoilsho	2236	21	compared	compare	VBN
cord-006229-7yoilsho	2236	22	to	to	IN
cord-006229-7yoilsho	2236	23	non	non	JJ
cord-006229-7yoilsho	2236	24	-	-	JJ
cord-006229-7yoilsho	2236	25	thrombosed	thrombosed	JJ
cord-006229-7yoilsho	2236	26	control	control	NN
cord-006229-7yoilsho	2236	27	veins	vein	NNS
cord-006229-7yoilsho	2236	28	suggesting	suggest	VBG
cord-006229-7yoilsho	2236	29	an	an	DT
cord-006229-7yoilsho	2236	30	elevated	elevated	JJ
cord-006229-7yoilsho	2236	31	IL-6	IL-6	NNP
cord-006229-7yoilsho	2236	32	regulation	regulation	NN
cord-006229-7yoilsho	2236	33	in	in	IN
cord-006229-7yoilsho	2236	34	thrombosed	thrombosed	JJ
cord-006229-7yoilsho	2236	35	vein	vein	NN
cord-006229-7yoilsho	2236	36	grafts	graft	NNS
cord-006229-7yoilsho	2236	37	in	in	IN
cord-006229-7yoilsho	2236	38	vivo	vivo	NN
cord-006229-7yoilsho	2236	39	.	.	.
cord-006229-7yoilsho	2237	1	In	in	IN
cord-006229-7yoilsho	2237	2	conclusion	conclusion	NN
cord-006229-7yoilsho	2237	3	,	,	,
cord-006229-7yoilsho	2237	4	FXa	FXa	NNS
cord-006229-7yoilsho	2237	5	induced	induce	VBD
cord-006229-7yoilsho	2237	6	IL-6	IL-6	NNP
cord-006229-7yoilsho	2237	7	expression	expression	NN
cord-006229-7yoilsho	2237	8	and	and	CC
cord-006229-7yoilsho	2237	9	secretion	secretion	NN
cord-006229-7yoilsho	2237	10	in	in	IN
cord-006229-7yoilsho	2237	11	venous	venous	JJ
cord-006229-7yoilsho	2237	12	SMC	smc	NN
cord-006229-7yoilsho	2237	13	which	which	WDT
cord-006229-7yoilsho	2237	14	may	may	MD
cord-006229-7yoilsho	2237	15	be	be	VB
cord-006229-7yoilsho	2237	16	regulated	regulate	VBN
cord-006229-7yoilsho	2237	17	via	via	IN
cord-006229-7yoilsho	2238	1	p38	p38	NNP
cord-006229-7yoilsho	2238	2	and	and	CC
cord-006229-7yoilsho	2238	3	PI3	PI3	NNP
cord-006229-7yoilsho	2238	4	K	K	NNP
cord-006229-7yoilsho	2238	5	signaling	signaling	NN
cord-006229-7yoilsho	2238	6	.	.	.
cord-006229-7yoilsho	2239	1	IL-6	IL-6	NNP
cord-006229-7yoilsho	2239	2	enhanced	enhance	VBN
cord-006229-7yoilsho	2239	3	TF	TF	NNP
cord-006229-7yoilsho	2239	4	expression	expression	NN
cord-006229-7yoilsho	2239	5	in	in	IN
cord-006229-7yoilsho	2239	6	THP-1	THP-1	NNP
cord-006229-7yoilsho	2239	7	monocytes	monocyte	NNS
cord-006229-7yoilsho	2239	8	and	and	CC
cord-006229-7yoilsho	2239	9	was	be	VBD
cord-006229-7yoilsho	2239	10	found	find	VBN
cord-006229-7yoilsho	2239	11	in	in	IN
cord-006229-7yoilsho	2239	12	SMC	SMC	NNP
cord-006229-7yoilsho	2239	13	-	-	HYPH
cord-006229-7yoilsho	2239	14	rich	rich	JJ
cord-006229-7yoilsho	2239	15	regions	region	NNS
cord-006229-7yoilsho	2239	16	in	in	IN
cord-006229-7yoilsho	2239	17	failed	fail	VBN
cord-006229-7yoilsho	2239	18	thrombosed	thrombosed	JJ
cord-006229-7yoilsho	2239	19	vein	vein	NN
cord-006229-7yoilsho	2239	20	grafts	graft	NNS
cord-006229-7yoilsho	2239	21	.	.	.
cord-006229-7yoilsho	2240	1	FXa	FXa	NNS
cord-006229-7yoilsho	2240	2	-	-	HYPH
cord-006229-7yoilsho	2240	3	stimulated	stimulate	VBN
cord-006229-7yoilsho	2240	4	IL-6	IL-6	NNP
cord-006229-7yoilsho	2240	5	release	release	NN
cord-006229-7yoilsho	2240	6	may	may	MD
cord-006229-7yoilsho	2240	7	be	be	VB
cord-006229-7yoilsho	2240	8	involved	involve	VBN
cord-006229-7yoilsho	2240	9	in	in	IN
cord-006229-7yoilsho	2240	10	regulating	regulate	VBG
cord-006229-7yoilsho	2240	11	local	local	JJ
cord-006229-7yoilsho	2240	12	pro	pro	JJ
cord-006229-7yoilsho	2240	13	-	-	JJ
cord-006229-7yoilsho	2240	14	thrombotic	thrombotic	JJ
cord-006229-7yoilsho	2240	15	processes	process	NNS
cord-006229-7yoilsho	2240	16	during	during	IN
cord-006229-7yoilsho	2240	17	vascular	vascular	JJ
cord-006229-7yoilsho	2240	18	inflammation	inflammation	NN
cord-006229-7yoilsho	2240	19	and	and	CC
cord-006229-7yoilsho	2240	20	possibly	possibly	RB
cord-006229-7yoilsho	2240	21	vein	vein	NN
cord-006229-7yoilsho	2240	22	graft	graft	NN
cord-006229-7yoilsho	2240	23	failure	failure	NN
cord-006229-7yoilsho	2240	24	.	.	.
cord-006229-7yoilsho	2241	1	Rationale	rationale	NN
cord-006229-7yoilsho	2241	2	:	:	:
cord-006229-7yoilsho	2242	1	The	the	DT
cord-006229-7yoilsho	2242	2	transcription	transcription	NN
cord-006229-7yoilsho	2242	3	factors	factor	VBZ
cord-006229-7yoilsho	2242	4	cAMP	camp	NN
cord-006229-7yoilsho	2242	5	-	-	HYPH
cord-006229-7yoilsho	2242	6	response	response	NN
cord-006229-7yoilsho	2242	7	element	element	NN
cord-006229-7yoilsho	2242	8	binding	bind	VBG
cord-006229-7yoilsho	2242	9	protein	protein	NN
cord-006229-7yoilsho	2242	10	(	(	-LRB-
cord-006229-7yoilsho	2242	11	CREB	CREB	NNP
cord-006229-7yoilsho	2242	12	)	)	-RRB-
cord-006229-7yoilsho	2242	13	and	and	CC
cord-006229-7yoilsho	2242	14	cAMP	camp	NN
cord-006229-7yoilsho	2242	15	-	-	HYPH
cord-006229-7yoilsho	2242	16	responsive	responsive	JJ
cord-006229-7yoilsho	2242	17	element	element	NN
cord-006229-7yoilsho	2242	18	modulator	modulator	NN
cord-006229-7yoilsho	2242	19	(	(	-LRB-
cord-006229-7yoilsho	2242	20	CREM	CREM	NNP
cord-006229-7yoilsho	2242	21	)	)	-RRB-
cord-006229-7yoilsho	2242	22	bind	bind	VB
cord-006229-7yoilsho	2242	23	to	to	IN
cord-006229-7yoilsho	2242	24	cAMP	camp	NN
cord-006229-7yoilsho	2242	25	response	response	NN
cord-006229-7yoilsho	2242	26	elements	element	NNS
cord-006229-7yoilsho	2242	27	(	(	-LRB-
cord-006229-7yoilsho	2242	28	CREs	CREs	NNP
cord-006229-7yoilsho	2242	29	)	)	-RRB-
cord-006229-7yoilsho	2242	30	and	and	CC
cord-006229-7yoilsho	2242	31	mediate	mediate	VB
cord-006229-7yoilsho	2242	32	a	a	DT
cord-006229-7yoilsho	2242	33	cAMP	camp	NN
cord-006229-7yoilsho	2242	34	dependent	dependent	JJ
cord-006229-7yoilsho	2242	35	gene	gene	NN
cord-006229-7yoilsho	2242	36	regulation	regulation	NN
cord-006229-7yoilsho	2242	37	.	.	.
cord-006229-7yoilsho	2243	1	Suppression	suppression	NN
cord-006229-7yoilsho	2243	2	of	of	IN
cord-006229-7yoilsho	2243	3	CRE	CRE	NNP
cord-006229-7yoilsho	2243	4	mediated	mediate	VBN
cord-006229-7yoilsho	2243	5	transcription	transcription	NN
cord-006229-7yoilsho	2243	6	is	be	VBZ
cord-006229-7yoilsho	2243	7	linked	link	VBN
cord-006229-7yoilsho	2243	8	to	to	IN
cord-006229-7yoilsho	2243	9	atrial	atrial	JJ
cord-006229-7yoilsho	2243	10	remodeling	remodeling	NN
cord-006229-7yoilsho	2243	11	in	in	IN
cord-006229-7yoilsho	2243	12	genetic	genetic	JJ
cord-006229-7yoilsho	2243	13	mouse	mouse	NN
cord-006229-7yoilsho	2243	14	models	model	NNS
cord-006229-7yoilsho	2243	15	.	.	.
cord-006229-7yoilsho	2244	1	Inhibition	inhibition	NN
cord-006229-7yoilsho	2244	2	of	of	IN
cord-006229-7yoilsho	2244	3	CREB	CREB	NNP
cord-006229-7yoilsho	2244	4	target	target	NN
cord-006229-7yoilsho	2244	5	genes	gene	NNS
cord-006229-7yoilsho	2244	6	is	be	VBZ
cord-006229-7yoilsho	2244	7	associated	associate	VBN
cord-006229-7yoilsho	2244	8	with	with	IN
cord-006229-7yoilsho	2244	9	atrial	atrial	JJ
cord-006229-7yoilsho	2244	10	fibrillation	fibrillation	NN
cord-006229-7yoilsho	2244	11	(	(	-LRB-
cord-006229-7yoilsho	2244	12	AF	AF	NNP
cord-006229-7yoilsho	2244	13	)	)	-RRB-
cord-006229-7yoilsho	2244	14	susceptibility	susceptibility	NN
cord-006229-7yoilsho	2244	15	in	in	IN
cord-006229-7yoilsho	2244	16	patients	patient	NNS
cord-006229-7yoilsho	2244	17	.	.	.
cord-006229-7yoilsho	2245	1	CREB	CREB	NNP
cord-006229-7yoilsho	2245	2	and	and	CC
cord-006229-7yoilsho	2245	3	CREM	CREM	NNP
cord-006229-7yoilsho	2245	4	affect	affect	VBP
cord-006229-7yoilsho	2245	5	histone	histone	NN
cord-006229-7yoilsho	2245	6	acetylation	acetylation	NN
cord-006229-7yoilsho	2245	7	recruiting	recruit	VBG
cord-006229-7yoilsho	2245	8	the	the	DT
cord-006229-7yoilsho	2245	9	CREB	CREB	NNP
cord-006229-7yoilsho	2245	10	-	-	HYPH
cord-006229-7yoilsho	2245	11	binding	bind	VBG
cord-006229-7yoilsho	2245	12	protein	protein	NN
cord-006229-7yoilsho	2245	13	(	(	-LRB-
cord-006229-7yoilsho	2245	14	CBP	CBP	NNP
cord-006229-7yoilsho	2245	15	/	/	SYM
cord-006229-7yoilsho	2245	16	p300	p300	NNP
cord-006229-7yoilsho	2245	17	)	)	-RRB-
cord-006229-7yoilsho	2245	18	.	.	.
cord-006229-7yoilsho	2246	1	The	the	DT
cord-006229-7yoilsho	2246	2	histone	histone	NN
cord-006229-7yoilsho	2246	3	acetyltransferase	acetyltransferase	NN
cord-006229-7yoilsho	2246	4	(	(	-LRB-
cord-006229-7yoilsho	2246	5	HAT	hat	NN
cord-006229-7yoilsho	2246	6	)	)	-RRB-
cord-006229-7yoilsho	2246	7	activity	activity	NN
cord-006229-7yoilsho	2246	8	of	of	IN
cord-006229-7yoilsho	2246	9	CBP	CBP	NNP
cord-006229-7yoilsho	2246	10	facilitates	facilitate	VBZ
cord-006229-7yoilsho	2246	11	gene	gene	NN
cord-006229-7yoilsho	2246	12	transcription	transcription	NN
cord-006229-7yoilsho	2246	13	by	by	IN
cord-006229-7yoilsho	2246	14	loosening	loosen	VBG
cord-006229-7yoilsho	2246	15	chromatin	chromatin	NN
cord-006229-7yoilsho	2246	16	structure	structure	NN
cord-006229-7yoilsho	2246	17	.	.	.
cord-006229-7yoilsho	2247	1	Histone	Histone	NNP
cord-006229-7yoilsho	2247	2	deacetylases	deacetylase	NNS
cord-006229-7yoilsho	2247	3	(	(	-LRB-
cord-006229-7yoilsho	2247	4	HDACs	hdac	NNS
cord-006229-7yoilsho	2247	5	)	)	-RRB-
cord-006229-7yoilsho	2247	6	catalyze	catalyze	VB
cord-006229-7yoilsho	2247	7	the	the	DT
cord-006229-7yoilsho	2247	8	inverse	inverse	JJ
cord-006229-7yoilsho	2247	9	reaction	reaction	NN
cord-006229-7yoilsho	2247	10	:	:	:
cord-006229-7yoilsho	2247	11	histone	histone	NN
cord-006229-7yoilsho	2247	12	deacetylation	deacetylation	NN
cord-006229-7yoilsho	2247	13	with	with	IN
cord-006229-7yoilsho	2247	14	consecutive	consecutive	JJ
cord-006229-7yoilsho	2247	15	gene	gene	NN
cord-006229-7yoilsho	2247	16	silencing	silencing	NN
cord-006229-7yoilsho	2247	17	.	.	.
cord-006229-7yoilsho	2248	1	Mice	mouse	NNS
cord-006229-7yoilsho	2248	2	with	with	IN
cord-006229-7yoilsho	2248	3	heart	heart	NN
cord-006229-7yoilsho	2248	4	directed	direct	VBD
cord-006229-7yoilsho	2248	5	expression	expression	NN
cord-006229-7yoilsho	2248	6	of	of	IN
cord-006229-7yoilsho	2248	7	the	the	DT
cord-006229-7yoilsho	2248	8	human	human	JJ
cord-006229-7yoilsho	2248	9	cardiac	cardiac	JJ
cord-006229-7yoilsho	2248	10	isoform	isoform	NN
cord-006229-7yoilsho	2248	11	CREM	CREM	NNP
cord-006229-7yoilsho	2248	12	-	-	HYPH
cord-006229-7yoilsho	2248	13	Ib∆C	Ib∆C	NNP
cord-006229-7yoilsho	2248	14	-	-	HYPH
cord-006229-7yoilsho	2248	15	X	x	NN
cord-006229-7yoilsho	2248	16	(	(	-LRB-
cord-006229-7yoilsho	2248	17	TG	TG	NNP
cord-006229-7yoilsho	2248	18	)	)	-RRB-
cord-006229-7yoilsho	2248	19	show	show	VBP
cord-006229-7yoilsho	2248	20	atrial	atrial	JJ
cord-006229-7yoilsho	2248	21	dilatation	dilatation	NN
cord-006229-7yoilsho	2248	22	,	,	,
cord-006229-7yoilsho	2248	23	morphological	morphological	JJ
cord-006229-7yoilsho	2248	24	and	and	CC
cord-006229-7yoilsho	2248	25	physiological	physiological	JJ
cord-006229-7yoilsho	2248	26	alterations	alteration	NNS
cord-006229-7yoilsho	2248	27	in	in	IN
cord-006229-7yoilsho	2248	28	atria	atria	NN
cord-006229-7yoilsho	2248	29	preceding	precede	VBG
cord-006229-7yoilsho	2248	30	spontaneous	spontaneous	JJ
cord-006229-7yoilsho	2248	31	-	-	HYPH
cord-006229-7yoilsho	2248	32	onset	onset	NN
cord-006229-7yoilsho	2248	33	AF	af	NN
cord-006229-7yoilsho	2248	34	.	.	.
cord-006229-7yoilsho	2249	1	The	the	DT
cord-006229-7yoilsho	2249	2	HDAC	HDAC	NNP
cord-006229-7yoilsho	2249	3	inhibitor	inhibitor	NN
cord-006229-7yoilsho	2249	4	(	(	-LRB-
cord-006229-7yoilsho	2249	5	HDAC	HDAC	NNP
cord-006229-7yoilsho	2249	6	i	i	NN
cord-006229-7yoilsho	2249	7	)	)	-RRB-
cord-006229-7yoilsho	2249	8	valproic	valproic	VBG
cord-006229-7yoilsho	2249	9	acid	acid	NN
cord-006229-7yoilsho	2249	10	(	(	-LRB-
cord-006229-7yoilsho	2249	11	VPA	VPA	NNP
cord-006229-7yoilsho	2249	12	)	)	-RRB-
cord-006229-7yoilsho	2249	13	reduced	reduce	VBN
cord-006229-7yoilsho	2249	14	atrial	atrial	JJ
cord-006229-7yoilsho	2249	15	weight	weight	NN
cord-006229-7yoilsho	2249	16	and	and	CC
cord-006229-7yoilsho	2249	17	AF	af	NN
cord-006229-7yoilsho	2249	18	incidence	incidence	NN
cord-006229-7yoilsho	2249	19	in	in	IN
cord-006229-7yoilsho	2249	20	TG	TG	NNP
cord-006229-7yoilsho	2249	21	mice	mouse	NNS
cord-006229-7yoilsho	2249	22	.	.	.
cord-006229-7yoilsho	2250	1	Here	here	RB
cord-006229-7yoilsho	2250	2	we	-PRON-	PRP
cord-006229-7yoilsho	2250	3	tested	test	VBD
cord-006229-7yoilsho	2250	4	the	the	DT
cord-006229-7yoilsho	2250	5	hypothesis	hypothesis	NN
cord-006229-7yoilsho	2250	6	,	,	,
cord-006229-7yoilsho	2250	7	that	that	IN
cord-006229-7yoilsho	2250	8	VPA	VPA	NNP
cord-006229-7yoilsho	2250	9	attenuates	attenuate	VBZ
cord-006229-7yoilsho	2250	10	the	the	DT
cord-006229-7yoilsho	2250	11	structural	structural	JJ
cord-006229-7yoilsho	2250	12	remodeling	remodeling	NN
cord-006229-7yoilsho	2250	13	in	in	IN
cord-006229-7yoilsho	2250	14	TG	TG	NNP
cord-006229-7yoilsho	2250	15	atria	atria	NN
cord-006229-7yoilsho	2250	16	by	by	IN
cord-006229-7yoilsho	2250	17	reversing	reverse	VBG
cord-006229-7yoilsho	2250	18	changes	change	NNS
cord-006229-7yoilsho	2250	19	in	in	IN
cord-006229-7yoilsho	2250	20	atrial	atrial	JJ
cord-006229-7yoilsho	2250	21	gene	gene	NN
cord-006229-7yoilsho	2250	22	regulation	regulation	NN
cord-006229-7yoilsho	2250	23	due	due	IN
cord-006229-7yoilsho	2250	24	to	to	IN
cord-006229-7yoilsho	2250	25	the	the	DT
cord-006229-7yoilsho	2250	26	transgene	transgene	NN
cord-006229-7yoilsho	2250	27	.	.	.
cord-006229-7yoilsho	2251	1	Methods	method	NNS
cord-006229-7yoilsho	2251	2	and	and	CC
cord-006229-7yoilsho	2251	3	Results	result	NNS
cord-006229-7yoilsho	2251	4	:	:	:
cord-006229-7yoilsho	2251	5	TG	TG	NNP
cord-006229-7yoilsho	2251	6	and	and	CC
cord-006229-7yoilsho	2251	7	WT	WT	NNP
cord-006229-7yoilsho	2251	8	mice	mouse	NNS
cord-006229-7yoilsho	2251	9	were	be	VBD
cord-006229-7yoilsho	2251	10	treated	treat	VBN
cord-006229-7yoilsho	2251	11	from	from	IN
cord-006229-7yoilsho	2251	12	week	week	NN
cord-006229-7yoilsho	2251	13	5	5	CD
cord-006229-7yoilsho	2251	14	-	-	SYM
cord-006229-7yoilsho	2251	15	16	16	CD
cord-006229-7yoilsho	2251	16	with	with	IN
cord-006229-7yoilsho	2251	17	VPA	VPA	NNP
cord-006229-7yoilsho	2251	18	(	(	-LRB-
cord-006229-7yoilsho	2251	19	0.71	0.71	CD
cord-006229-7yoilsho	2251	20	%	%	NN
cord-006229-7yoilsho	2251	21	in	in	IN
cord-006229-7yoilsho	2251	22	drinking	drinking	NN
cord-006229-7yoilsho	2251	23	water	water	NN
cord-006229-7yoilsho	2251	24	,	,	,
cord-006229-7yoilsho	2251	25	ad	ad	NN
cord-006229-7yoilsho	2251	26	libitum	libitum	NN
cord-006229-7yoilsho	2251	27	)	)	-RRB-
cord-006229-7yoilsho	2251	28	or	or	CC
cord-006229-7yoilsho	2251	29	vehicle	vehicle	NN
cord-006229-7yoilsho	2251	30	(	(	-LRB-
cord-006229-7yoilsho	2251	31	Veh	Veh	NNP
cord-006229-7yoilsho	2251	32	)	)	-RRB-
cord-006229-7yoilsho	2251	33	.	.	.
cord-006229-7yoilsho	2252	1	Atrial	atrial	JJ
cord-006229-7yoilsho	2252	2	ultrastructure	ultrastructure	NN
cord-006229-7yoilsho	2252	3	was	be	VBD
cord-006229-7yoilsho	2252	4	studied	study	VBN
cord-006229-7yoilsho	2252	5	by	by	IN
cord-006229-7yoilsho	2252	6	electron	electron	NN
cord-006229-7yoilsho	2252	7	microscopy	microscopy	NNS
cord-006229-7yoilsho	2252	8	(	(	-LRB-
cord-006229-7yoilsho	2252	9	EM	EM	NNP
cord-006229-7yoilsho	2252	10	)	)	-RRB-
cord-006229-7yoilsho	2252	11	(	(	-LRB-
cord-006229-7yoilsho	2252	12	week	week	NN
cord-006229-7yoilsho	2252	13	7	7	CD
cord-006229-7yoilsho	2252	14	and	and	CC
cord-006229-7yoilsho	2252	15	16	16	CD
cord-006229-7yoilsho	2252	16	)	)	-RRB-
cord-006229-7yoilsho	2252	17	.	.	.
cord-006229-7yoilsho	2253	1	Veh	Veh	NNP
cord-006229-7yoilsho	2253	2	-	-	HYPH
cord-006229-7yoilsho	2253	3	treated	treat	VBN
cord-006229-7yoilsho	2253	4	TG	TG	NNP
cord-006229-7yoilsho	2253	5	atria	atrium	NNS
cord-006229-7yoilsho	2253	6	showed	show	VBD
cord-006229-7yoilsho	2253	7	a	a	DT
cord-006229-7yoilsho	2253	8	progressive	progressive	JJ
cord-006229-7yoilsho	2253	9	dysorganisation	dysorganisation	NN
cord-006229-7yoilsho	2253	10	of	of	IN
cord-006229-7yoilsho	2253	11	sarcomeres	sarcomere	NNS
cord-006229-7yoilsho	2253	12	(	(	-LRB-
cord-006229-7yoilsho	2253	13	SM	SM	NNP
cord-006229-7yoilsho	2253	14	)	)	-RRB-
cord-006229-7yoilsho	2253	15	with	with	IN
cord-006229-7yoilsho	2253	16	less	less	JJR
cord-006229-7yoilsho	2253	17	mitochondria	mitochondrion	NNS
cord-006229-7yoilsho	2253	18	and	and	CC
cord-006229-7yoilsho	2253	19	more	more	JJR
cord-006229-7yoilsho	2253	20	collagen	collagen	NN
cord-006229-7yoilsho	2253	21	fibers	fiber	NNS
cord-006229-7yoilsho	2253	22	between	between	IN
cord-006229-7yoilsho	2253	23	cardiomyocytes	cardiomyocyte	NNS
cord-006229-7yoilsho	2253	24	as	as	IN
cord-006229-7yoilsho	2253	25	compared	compare	VBN
cord-006229-7yoilsho	2253	26	to	to	IN
cord-006229-7yoilsho	2253	27	Veh	Veh	NNP
cord-006229-7yoilsho	2253	28	-	-	HYPH
cord-006229-7yoilsho	2253	29	treated	treat	VBN
cord-006229-7yoilsho	2253	30	WT	WT	NNP
cord-006229-7yoilsho	2253	31	atria	atria	NN
cord-006229-7yoilsho	2253	32	.	.	.
cord-006229-7yoilsho	2254	1	The	the	DT
cord-006229-7yoilsho	2254	2	fraction	fraction	NN
cord-006229-7yoilsho	2254	3	of	of	IN
cord-006229-7yoilsho	2254	4	SM	sm	NN
cord-006229-7yoilsho	2254	5	structure	structure	NN
cord-006229-7yoilsho	2254	6	in	in	IN
cord-006229-7yoilsho	2254	7	Veh	Veh	NNP
cord-006229-7yoilsho	2254	8	-	-	HYPH
cord-006229-7yoilsho	2254	9	treated	treat	VBN
cord-006229-7yoilsho	2254	10	TG	TG	NNP
cord-006229-7yoilsho	2254	11	atria	atria	NN
cord-006229-7yoilsho	2254	12	was	be	VBD
cord-006229-7yoilsho	2254	13	significantly	significantly	RB
cord-006229-7yoilsho	2254	14	reduced	reduce	VBN
cord-006229-7yoilsho	2254	15	as	as	IN
cord-006229-7yoilsho	2254	16	compared	compare	VBN
cord-006229-7yoilsho	2254	17	to	to	IN
cord-006229-7yoilsho	2254	18	Veh	Veh	NNP
cord-006229-7yoilsho	2254	19	-	-	HYPH
cord-006229-7yoilsho	2254	20	treated	treat	VBN
cord-006229-7yoilsho	2254	21	WT	WT	NNP
cord-006229-7yoilsho	2254	22	atria	atria	NN
cord-006229-7yoilsho	2254	23	(	(	-LRB-
cord-006229-7yoilsho	2254	24	week	week	NN
cord-006229-7yoilsho	2254	25	7	7	CD
cord-006229-7yoilsho	2254	26	:	:	:
cord-006229-7yoilsho	2254	27	TG	TG	NNP
cord-006229-7yoilsho	2254	28	Veh	Veh	NNP
cord-006229-7yoilsho	2254	29	:	:	:
cord-006229-7yoilsho	2254	30	33±2	33±2	CD
cord-006229-7yoilsho	2254	31	%	%	NN
cord-006229-7yoilsho	2254	32	,	,	,
cord-006229-7yoilsho	2254	33	WT	WT	NNP
cord-006229-7yoilsho	2254	34	Veh	Veh	NNP
cord-006229-7yoilsho	2254	35	:	:	:
cord-006229-7yoilsho	2254	36	47±1	47±1	CD
cord-006229-7yoilsho	2254	37	%	%	NN
cord-006229-7yoilsho	2254	38	;	;	:
cord-006229-7yoilsho	2254	39	week	week	NN
cord-006229-7yoilsho	2254	40	16	16	CD
cord-006229-7yoilsho	2254	41	:	:	:
cord-006229-7yoilsho	2254	42	TG	TG	NNP
cord-006229-7yoilsho	2254	43	Veh	Veh	NNP
cord-006229-7yoilsho	2254	44	:	:	:
cord-006229-7yoilsho	2254	45	19±2	19±2	CD
cord-006229-7yoilsho	2254	46	%	%	NN
cord-006229-7yoilsho	2254	47	,	,	,
cord-006229-7yoilsho	2254	48	WT	WT	NNP
cord-006229-7yoilsho	2254	49	Veh	Veh	NNP
cord-006229-7yoilsho	2254	50	:	:	:
cord-006229-7yoilsho	2254	51	44±1	44±1	CD
cord-006229-7yoilsho	2254	52	%	%	NN
cord-006229-7yoilsho	2254	53	,	,	,
cord-006229-7yoilsho	2254	54	P<0.05	P<0.05	NNS
cord-006229-7yoilsho	2254	55	)	)	-RRB-
cord-006229-7yoilsho	2254	56	.	.	.
cord-006229-7yoilsho	2255	1	VPA	VPA	NNP
cord-006229-7yoilsho	2255	2	led	lead	VBD
cord-006229-7yoilsho	2255	3	to	to	IN
cord-006229-7yoilsho	2255	4	a	a	DT
cord-006229-7yoilsho	2255	5	more	more	RBR
cord-006229-7yoilsho	2255	6	organized	organized	JJ
cord-006229-7yoilsho	2255	7	ultrastructure	ultrastructure	NN
cord-006229-7yoilsho	2255	8	and	and	CC
cord-006229-7yoilsho	2255	9	restored	restore	VBN
cord-006229-7yoilsho	2255	10	,	,	,
cord-006229-7yoilsho	2255	11	at	at	IN
cord-006229-7yoilsho	2255	12	least	least	JJS
cord-006229-7yoilsho	2255	13	partially	partially	RB
cord-006229-7yoilsho	2255	14	,	,	,
cord-006229-7yoilsho	2255	15	the	the	DT
cord-006229-7yoilsho	2255	16	degradation	degradation	NN
cord-006229-7yoilsho	2255	17	of	of	IN
cord-006229-7yoilsho	2255	18	the	the	DT
cord-006229-7yoilsho	2255	19	SM	sm	NN
cord-006229-7yoilsho	2255	20	in	in	IN
cord-006229-7yoilsho	2255	21	the	the	DT
cord-006229-7yoilsho	2255	22	TG	TG	NNP
cord-006229-7yoilsho	2255	23	atria	atria	NN
cord-006229-7yoilsho	2256	1	(	(	-LRB-
cord-006229-7yoilsho	2256	2	TG	TG	NNP
cord-006229-7yoilsho	2256	3	VPA	VPA	NNP
cord-006229-7yoilsho	2256	4	at	at	IN
cord-006229-7yoilsho	2256	5	week	week	NN
cord-006229-7yoilsho	2256	6	7	7	CD
cord-006229-7yoilsho	2256	7	:	:	SYM
cord-006229-7yoilsho	2256	8	40±2	40±2	CD
cord-006229-7yoilsho	2256	9	%	%	NN
cord-006229-7yoilsho	2256	10	,	,	,
cord-006229-7yoilsho	2256	11	TG	TG	NNP
cord-006229-7yoilsho	2256	12	VPA	VPA	NNP
cord-006229-7yoilsho	2256	13	at	at	IN
cord-006229-7yoilsho	2256	14	week	week	NN
cord-006229-7yoilsho	2256	15	16	16	CD
cord-006229-7yoilsho	2256	16	:	:	:
cord-006229-7yoilsho	2256	17	34±1	34±1	CD
cord-006229-7yoilsho	2256	18	%	%	NN
cord-006229-7yoilsho	2256	19	,	,	,
cord-006229-7yoilsho	2256	20	P<0.05	p<0.05	JJ
cord-006229-7yoilsho	2256	21	vs.	vs.	IN
cord-006229-7yoilsho	2256	22	TG	TG	NNP
cord-006229-7yoilsho	2256	23	Veh	Veh	NNP
cord-006229-7yoilsho	2256	24	)	)	-RRB-
cord-006229-7yoilsho	2256	25	.	.	.
cord-006229-7yoilsho	2257	1	The	the	DT
cord-006229-7yoilsho	2257	2	structure	structure	NN
cord-006229-7yoilsho	2257	3	of	of	IN
cord-006229-7yoilsho	2257	4	WT	WT	NNP
cord-006229-7yoilsho	2257	5	atria	atria	NN
cord-006229-7yoilsho	2257	6	was	be	VBD
cord-006229-7yoilsho	2257	7	not	not	RB
cord-006229-7yoilsho	2257	8	affected	affect	VBN
cord-006229-7yoilsho	2257	9	by	by	IN
cord-006229-7yoilsho	2257	10	VPA	VPA	NNP
cord-006229-7yoilsho	2257	11	.	.	.
cord-006229-7yoilsho	2258	1	We	-PRON-	PRP
cord-006229-7yoilsho	2258	2	further	further	RB
cord-006229-7yoilsho	2258	3	analyzed	analyze	VBD
cord-006229-7yoilsho	2258	4	the	the	DT
cord-006229-7yoilsho	2258	5	protein	protein	NN
cord-006229-7yoilsho	2258	6	abundance	abundance	NN
cord-006229-7yoilsho	2258	7	profiles	profile	NNS
cord-006229-7yoilsho	2258	8	in	in	IN
cord-006229-7yoilsho	2258	9	the	the	DT
cord-006229-7yoilsho	2258	10	groups	group	NNS
cord-006229-7yoilsho	2258	11	of	of	IN
cord-006229-7yoilsho	2258	12	all	all	DT
cord-006229-7yoilsho	2258	13	animals	animal	NNS
cord-006229-7yoilsho	2258	14	(	(	-LRB-
cord-006229-7yoilsho	2258	15	WT	WT	NNP
cord-006229-7yoilsho	2258	16	Veh	Veh	NNP
cord-006229-7yoilsho	2258	17	,	,	,
cord-006229-7yoilsho	2258	18	WT	WT	NNP
cord-006229-7yoilsho	2258	19	VPA	VPA	NNP
cord-006229-7yoilsho	2258	20	,	,	,
cord-006229-7yoilsho	2258	21	TG	TG	NNP
cord-006229-7yoilsho	2258	22	Veh	Veh	NNP
cord-006229-7yoilsho	2258	23	,	,	,
cord-006229-7yoilsho	2258	24	TG	TG	NNP
cord-006229-7yoilsho	2258	25	VPA	VPA	NNP
cord-006229-7yoilsho	2258	26	)	)	-RRB-
cord-006229-7yoilsho	2258	27	by	by	IN
cord-006229-7yoilsho	2258	28	using	use	VBG
cord-006229-7yoilsho	2258	29	LC	LC	NNP
cord-006229-7yoilsho	2258	30	-	-	HYPH
cord-006229-7yoilsho	2258	31	MS	MS	NNP
cord-006229-7yoilsho	2258	32	/	/	SYM
cord-006229-7yoilsho	2258	33	MS	MS	NNP
cord-006229-7yoilsho	2258	34	.	.	.
cord-006229-7yoilsho	2259	1	Between	between	IN
cord-006229-7yoilsho	2259	2	Veh	Veh	NNP
cord-006229-7yoilsho	2259	3	-	-	HYPH
cord-006229-7yoilsho	2259	4	treated	treat	VBN
cord-006229-7yoilsho	2259	5	genotypes	genotype	NNS
cord-006229-7yoilsho	2259	6	(	(	-LRB-
cord-006229-7yoilsho	2260	1	TG	TG	NNP
cord-006229-7yoilsho	2260	2	Veh	Veh	NNP
cord-006229-7yoilsho	2260	3	vs.	vs.	IN
cord-006229-7yoilsho	2260	4	WT	WT	NNP
cord-006229-7yoilsho	2260	5	Veh	Veh	NNP
cord-006229-7yoilsho	2260	6	,	,	,
cord-006229-7yoilsho	2260	7	P<0.05	P<0.05	NNS
cord-006229-7yoilsho	2260	8	)	)	-RRB-
cord-006229-7yoilsho	2260	9	998	998	CD
cord-006229-7yoilsho	2260	10	proteins	protein	NNS
cord-006229-7yoilsho	2260	11	were	be	VBD
cord-006229-7yoilsho	2260	12	significantly	significantly	RB
cord-006229-7yoilsho	2260	13	changed	change	VBN
cord-006229-7yoilsho	2260	14	while	while	IN
cord-006229-7yoilsho	2260	15	854	854	CD
cord-006229-7yoilsho	2260	16	proteins	protein	NNS
cord-006229-7yoilsho	2260	17	were	be	VBD
cord-006229-7yoilsho	2260	18	differentially	differentially	RB
cord-006229-7yoilsho	2260	19	abundant	abundant	JJ
cord-006229-7yoilsho	2260	20	between	between	IN
cord-006229-7yoilsho	2260	21	VPA	VPA	NNP
cord-006229-7yoilsho	2260	22	-	-	HYPH
cord-006229-7yoilsho	2260	23	treated	treat	VBN
cord-006229-7yoilsho	2260	24	groups	group	NNS
cord-006229-7yoilsho	2260	25	(	(	-LRB-
cord-006229-7yoilsho	2260	26	TG	TG	NNP
cord-006229-7yoilsho	2260	27	VPA	VPA	NNP
cord-006229-7yoilsho	2260	28	vs.	vs.	IN
cord-006229-7yoilsho	2260	29	WT	WT	NNP
cord-006229-7yoilsho	2260	30	VPA	VPA	NNP
cord-006229-7yoilsho	2260	31	,	,	,
cord-006229-7yoilsho	2260	32	P<0.05	P<0.05	NNS
cord-006229-7yoilsho	2260	33	)	)	-RRB-
cord-006229-7yoilsho	2260	34	.	.	.
cord-006229-7yoilsho	2261	1	109	109	CD
cord-006229-7yoilsho	2261	2	proteins	protein	NNS
cord-006229-7yoilsho	2261	3	were	be	VBD
cord-006229-7yoilsho	2261	4	regulated	regulate	VBN
cord-006229-7yoilsho	2261	5	by	by	IN
cord-006229-7yoilsho	2261	6	VPA	VPA	NNP
cord-006229-7yoilsho	2261	7	in	in	IN
cord-006229-7yoilsho	2261	8	WT	WT	NNP
cord-006229-7yoilsho	2261	9	atria	atria	NNP
cord-006229-7yoilsho	2262	1	(	(	-LRB-
cord-006229-7yoilsho	2262	2	WT	WT	NNP
cord-006229-7yoilsho	2262	3	VPA	VPA	NNP
cord-006229-7yoilsho	2262	4	vs.	vs.	IN
cord-006229-7yoilsho	2262	5	WT	WT	NNP
cord-006229-7yoilsho	2262	6	Veh	Veh	NNP
cord-006229-7yoilsho	2262	7	,	,	,
cord-006229-7yoilsho	2262	8	P<0.05	P<0.05	NNS
cord-006229-7yoilsho	2262	9	)	)	-RRB-
cord-006229-7yoilsho	2262	10	,	,	,
cord-006229-7yoilsho	2262	11	whereas	whereas	IN
cord-006229-7yoilsho	2262	12	VPA	VPA	NNP
cord-006229-7yoilsho	2262	13	affected	affect	VBD
cord-006229-7yoilsho	2262	14	525	525	CD
cord-006229-7yoilsho	2262	15	proteins	protein	NNS
cord-006229-7yoilsho	2262	16	in	in	IN
cord-006229-7yoilsho	2262	17	TG	TG	NNP
cord-006229-7yoilsho	2262	18	atria	atria	NNP
cord-006229-7yoilsho	2263	1	(	(	-LRB-
cord-006229-7yoilsho	2263	2	TG	TG	NNP
cord-006229-7yoilsho	2263	3	VPA	VPA	NNP
cord-006229-7yoilsho	2263	4	vs.	vs.	IN
cord-006229-7yoilsho	2263	5	TG	TG	NNP
cord-006229-7yoilsho	2263	6	Veh	Veh	NNP
cord-006229-7yoilsho	2263	7	,	,	,
cord-006229-7yoilsho	2263	8	P<0.05	P<0.05	NNS
cord-006229-7yoilsho	2263	9	)	)	-RRB-
cord-006229-7yoilsho	2263	10	,	,	,
cord-006229-7yoilsho	2263	11	out	out	IN
cord-006229-7yoilsho	2263	12	of	of	IN
cord-006229-7yoilsho	2263	13	which	which	WDT
cord-006229-7yoilsho	2263	14	43	43	CD
cord-006229-7yoilsho	2263	15	proteins	protein	NNS
cord-006229-7yoilsho	2263	16	were	be	VBD
cord-006229-7yoilsho	2263	17	common	common	JJ
cord-006229-7yoilsho	2263	18	.	.	.
cord-006229-7yoilsho	2264	1	295	295	CD
cord-006229-7yoilsho	2264	2	prominent	prominent	JJ
cord-006229-7yoilsho	2264	3	changed	change	VBN
cord-006229-7yoilsho	2264	4	proteins	protein	NNS
cord-006229-7yoilsho	2264	5	between	between	IN
cord-006229-7yoilsho	2264	6	Veh	Veh	NNP
cord-006229-7yoilsho	2264	7	-	-	HYPH
cord-006229-7yoilsho	2264	8	treated	treat	VBN
cord-006229-7yoilsho	2264	9	TG	TG	NNP
cord-006229-7yoilsho	2264	10	and	and	CC
cord-006229-7yoilsho	2264	11	WT	WT	NNP
cord-006229-7yoilsho	2264	12	atria	atrium	NNS
cord-006229-7yoilsho	2264	13	were	be	VBD
cord-006229-7yoilsho	2264	14	significantly	significantly	RB
cord-006229-7yoilsho	2264	15	regulated	regulate	VBN
cord-006229-7yoilsho	2264	16	by	by	IN
cord-006229-7yoilsho	2264	17	VPA	VPA	NNP
cord-006229-7yoilsho	2264	18	in	in	IN
cord-006229-7yoilsho	2264	19	TG	TG	NNP
cord-006229-7yoilsho	2264	20	atria	atria	NN
cord-006229-7yoilsho	2264	21	in	in	IN
cord-006229-7yoilsho	2264	22	the	the	DT
cord-006229-7yoilsho	2264	23	opposite	opposite	JJ
cord-006229-7yoilsho	2264	24	direction	direction	NN
cord-006229-7yoilsho	2264	25	.	.	.
cord-006229-7yoilsho	2265	1	A	a	DT
cord-006229-7yoilsho	2265	2	functional	functional	JJ
cord-006229-7yoilsho	2265	3	pathway	pathway	NN
cord-006229-7yoilsho	2265	4	analysis	analysis	NN
cord-006229-7yoilsho	2265	5	showed	show	VBD
cord-006229-7yoilsho	2265	6	that	that	IN
cord-006229-7yoilsho	2265	7	pathways	pathway	NNS
cord-006229-7yoilsho	2265	8	activated	activate	VBN
cord-006229-7yoilsho	2265	9	in	in	IN
cord-006229-7yoilsho	2265	10	TG	TG	NNP
cord-006229-7yoilsho	2265	11	atria	atria	NN
cord-006229-7yoilsho	2265	12	such	such	JJ
cord-006229-7yoilsho	2265	13	as	as	IN
cord-006229-7yoilsho	2265	14	cardiac	cardiac	JJ
cord-006229-7yoilsho	2265	15	fibrosis	fibrosis	NN
cord-006229-7yoilsho	2265	16	,	,	,
cord-006229-7yoilsho	2265	17	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	2265	18	dysfunction	dysfunction	NN
cord-006229-7yoilsho	2265	19	were	be	VBD
cord-006229-7yoilsho	2265	20	inhibited	inhibit	VBN
cord-006229-7yoilsho	2265	21	by	by	IN
cord-006229-7yoilsho	2265	22	VPA	VPA	NNP
cord-006229-7yoilsho	2265	23	treatment	treatment	NN
cord-006229-7yoilsho	2265	24	.	.	.
cord-006229-7yoilsho	2266	1	Conclusion	conclusion	NN
cord-006229-7yoilsho	2266	2	:	:	:
cord-006229-7yoilsho	2266	3	Similar	similar	JJ
cord-006229-7yoilsho	2266	4	to	to	IN
cord-006229-7yoilsho	2266	5	human	human	JJ
cord-006229-7yoilsho	2266	6	AF	af	NN
cord-006229-7yoilsho	2266	7	,	,	,
cord-006229-7yoilsho	2267	1	CREM	CREM	NNP
cord-006229-7yoilsho	2267	2	-	-	HYPH
cord-006229-7yoilsho	2267	3	TG	tg	NN
cord-006229-7yoilsho	2267	4	mice	mouse	NNS
cord-006229-7yoilsho	2267	5	present	present	JJ
cord-006229-7yoilsho	2267	6	atrial	atrial	JJ
cord-006229-7yoilsho	2267	7	dilatation	dilatation	NN
cord-006229-7yoilsho	2267	8	,	,	,
cord-006229-7yoilsho	2267	9	ultrastructural	ultrastructural	JJ
cord-006229-7yoilsho	2267	10	changes	change	NNS
cord-006229-7yoilsho	2267	11	and	and	CC
cord-006229-7yoilsho	2267	12	impaired	impair	VBN
cord-006229-7yoilsho	2267	13	conduction	conduction	NN
cord-006229-7yoilsho	2267	14	and	and	CC
cord-006229-7yoilsho	2267	15	spontaneous	spontaneous	JJ
cord-006229-7yoilsho	2267	16	AF	af	NN
cord-006229-7yoilsho	2267	17	.	.	.
cord-006229-7yoilsho	2268	1	While	while	IN
cord-006229-7yoilsho	2268	2	VPA	VPA	NNP
cord-006229-7yoilsho	2268	3	had	have	VBD
cord-006229-7yoilsho	2268	4	little	little	JJ
cord-006229-7yoilsho	2268	5	to	to	IN
cord-006229-7yoilsho	2268	6	no	no	DT
cord-006229-7yoilsho	2268	7	effect	effect	NN
cord-006229-7yoilsho	2268	8	in	in	IN
cord-006229-7yoilsho	2268	9	WT	WT	NNP
cord-006229-7yoilsho	2268	10	mice	mouse	NNS
cord-006229-7yoilsho	2268	11	,	,	,
cord-006229-7yoilsho	2268	12	valproate	valproate	RB
cord-006229-7yoilsho	2268	13	improved	improve	VBD
cord-006229-7yoilsho	2268	14	the	the	DT
cord-006229-7yoilsho	2268	15	TG	TG	NNP
cord-006229-7yoilsho	2268	16	phenotype	phenotype	NN
cord-006229-7yoilsho	2268	17	by	by	IN
cord-006229-7yoilsho	2268	18	interfering	interfere	VBG
cord-006229-7yoilsho	2268	19	with	with	IN
cord-006229-7yoilsho	2268	20	pathways	pathway	NNS
cord-006229-7yoilsho	2268	21	involved	involve	VBN
cord-006229-7yoilsho	2268	22	in	in	IN
cord-006229-7yoilsho	2268	23	structural	structural	JJ
cord-006229-7yoilsho	2268	24	remodeling	remodeling	NN
cord-006229-7yoilsho	2268	25	.	.	.
cord-006229-7yoilsho	2269	1	This	this	DT
cord-006229-7yoilsho	2269	2	supports	support	VBZ
cord-006229-7yoilsho	2269	3	the	the	DT
cord-006229-7yoilsho	2269	4	idea	idea	NN
cord-006229-7yoilsho	2269	5	that	that	IN
cord-006229-7yoilsho	2269	6	HDAC	HDAC	NNP
cord-006229-7yoilsho	2269	7	inhibition	inhibition	NN
cord-006229-7yoilsho	2269	8	by	by	IN
cord-006229-7yoilsho	2269	9	VPA	VPA	NNP
cord-006229-7yoilsho	2269	10	antagonizes	antagonize	VBZ
cord-006229-7yoilsho	2269	11	effects	effect	NNS
cord-006229-7yoilsho	2269	12	of	of	IN
cord-006229-7yoilsho	2269	13	CREM	crem	JJ
cord-006229-7yoilsho	2269	14	expression	expression	NN
cord-006229-7yoilsho	2269	15	in	in	IN
cord-006229-7yoilsho	2269	16	atria	atria	NN
cord-006229-7yoilsho	2269	17	.	.	.
cord-006229-7yoilsho	2270	1	In	in	IN
cord-006229-7yoilsho	2270	2	isolated	isolated	JJ
cord-006229-7yoilsho	2270	3	mouse	mouse	NN
cord-006229-7yoilsho	2270	4	cardiac	cardiac	JJ
cord-006229-7yoilsho	2270	5	preparations	preparation	NNS
cord-006229-7yoilsho	2270	6	,	,	,
cord-006229-7yoilsho	2270	7	histamine	histamine	NN
cord-006229-7yoilsho	2270	8	is	be	VBZ
cord-006229-7yoilsho	2270	9	ineffective	ineffective	JJ
cord-006229-7yoilsho	2270	10	regarding	regard	VBG
cord-006229-7yoilsho	2270	11	inotropic	inotropic	NNP
cord-006229-7yoilsho	2270	12	or	or	CC
cord-006229-7yoilsho	2270	13	chronotropic	chronotropic	JJ
cord-006229-7yoilsho	2270	14	effects	effect	NNS
cord-006229-7yoilsho	2270	15	,	,	,
cord-006229-7yoilsho	2270	16	presumably	presumably	RB
cord-006229-7yoilsho	2270	17	because	because	IN
cord-006229-7yoilsho	2270	18	of	of	IN
cord-006229-7yoilsho	2270	19	lack	lack	NN
cord-006229-7yoilsho	2270	20	of	of	IN
cord-006229-7yoilsho	2270	21	receptor	receptor	NN
cord-006229-7yoilsho	2270	22	protein	protein	NN
cord-006229-7yoilsho	2270	23	expression	expression	NN
cord-006229-7yoilsho	2270	24	.	.	.
cord-006229-7yoilsho	2271	1	On	on	IN
cord-006229-7yoilsho	2271	2	the	the	DT
cord-006229-7yoilsho	2271	3	other	other	JJ
cord-006229-7yoilsho	2271	4	hand	hand	NN
cord-006229-7yoilsho	2271	5	,	,	,
cord-006229-7yoilsho	2271	6	histamine	histamine	NN
cord-006229-7yoilsho	2271	7	can	can	MD
cord-006229-7yoilsho	2271	8	exert	exert	VB
cord-006229-7yoilsho	2271	9	positive	positive	JJ
cord-006229-7yoilsho	2271	10	inotropic	inotropic	NNP
cord-006229-7yoilsho	2271	11	and	and	CC
cord-006229-7yoilsho	2271	12	chronotropic	chronotropic	JJ
cord-006229-7yoilsho	2271	13	effects	effect	NNS
cord-006229-7yoilsho	2271	14	in	in	IN
cord-006229-7yoilsho	2271	15	humans	human	NNS
cord-006229-7yoilsho	2271	16	via	via	IN
cord-006229-7yoilsho	2271	17	cardiac	cardiac	JJ
cord-006229-7yoilsho	2271	18	histamine	histamine	NN
cord-006229-7yoilsho	2271	19	H	H	NNP
cord-006229-7yoilsho	2271	20	2	2	CD
cord-006229-7yoilsho	2271	21	-receptors	-receptor	NNS
cord-006229-7yoilsho	2271	22	.	.	.
cord-006229-7yoilsho	2272	1	Hence	hence	RB
cord-006229-7yoilsho	2272	2	,	,	,
cord-006229-7yoilsho	2272	3	we	-PRON-	PRP
cord-006229-7yoilsho	2272	4	have	have	VBP
cord-006229-7yoilsho	2272	5	generated	generate	VBN
cord-006229-7yoilsho	2272	6	transgenic	transgenic	JJ
cord-006229-7yoilsho	2272	7	mice	mouse	NNS
cord-006229-7yoilsho	2272	8	(	(	-LRB-
cord-006229-7yoilsho	2272	9	TG	TG	NNP
cord-006229-7yoilsho	2272	10	)	)	-RRB-
cord-006229-7yoilsho	2272	11	which	which	WDT
cord-006229-7yoilsho	2272	12	overexpress	overexpress	VBP
cord-006229-7yoilsho	2272	13	the	the	DT
cord-006229-7yoilsho	2272	14	human	human	JJ
cord-006229-7yoilsho	2272	15	H	h	NN
cord-006229-7yoilsho	2272	16	2	2	CD
cord-006229-7yoilsho	2272	17	-receptor	-receptor	NN
cord-006229-7yoilsho	2272	18	specifically	specifically	RB
cord-006229-7yoilsho	2272	19	in	in	IN
cord-006229-7yoilsho	2272	20	cardiomyocytes	cardiomyocyte	NNS
cord-006229-7yoilsho	2272	21	.	.	.
cord-006229-7yoilsho	2273	1	In	in	IN
cord-006229-7yoilsho	2273	2	isolated	isolated	JJ
cord-006229-7yoilsho	2273	3	left	left	JJ
cord-006229-7yoilsho	2273	4	and	and	CC
cord-006229-7yoilsho	2273	5	right	right	JJ
cord-006229-7yoilsho	2273	6	atrial	atrial	JJ
cord-006229-7yoilsho	2273	7	preparations	preparation	NNS
cord-006229-7yoilsho	2273	8	of	of	IN
cord-006229-7yoilsho	2273	9	these	these	DT
cord-006229-7yoilsho	2273	10	mice	mouse	NNS
cord-006229-7yoilsho	2273	11	,	,	,
cord-006229-7yoilsho	2273	12	we	-PRON-	PRP
cord-006229-7yoilsho	2273	13	investigated	investigate	VBD
cord-006229-7yoilsho	2273	14	the	the	DT
cord-006229-7yoilsho	2273	15	histamine	histamine	NN
cord-006229-7yoilsho	2273	16	metabolism	metabolism	NN
cord-006229-7yoilsho	2273	17	on	on	IN
cord-006229-7yoilsho	2273	18	a	a	DT
cord-006229-7yoilsho	2273	19	functional	functional	JJ
cord-006229-7yoilsho	2273	20	level	level	NN
cord-006229-7yoilsho	2273	21	.	.	.
cord-006229-7yoilsho	2274	1	Preparations	preparation	NNS
cord-006229-7yoilsho	2274	2	of	of	IN
cord-006229-7yoilsho	2274	3	wild	wild	JJ
cord-006229-7yoilsho	2274	4	type	type	NN
cord-006229-7yoilsho	2274	5	mice	mouse	NNS
cord-006229-7yoilsho	2274	6	(	(	-LRB-
cord-006229-7yoilsho	2274	7	WT	WT	NNP
cord-006229-7yoilsho	2274	8	)	)	-RRB-
cord-006229-7yoilsho	2274	9	served	serve	VBD
cord-006229-7yoilsho	2274	10	as	as	IN
cord-006229-7yoilsho	2274	11	control	control	NN
cord-006229-7yoilsho	2274	12	.	.	.
cord-006229-7yoilsho	2275	1	Histamine	histamine	NN
cord-006229-7yoilsho	2275	2	induced	induce	VBD
cord-006229-7yoilsho	2275	3	positive	positive	JJ
cord-006229-7yoilsho	2275	4	inotropic	inotropic	JJ
cord-006229-7yoilsho	2275	5	effects	effect	NNS
cord-006229-7yoilsho	2275	6	(	(	-LRB-
cord-006229-7yoilsho	2275	7	PIE	pie	NN
cord-006229-7yoilsho	2275	8	)	)	-RRB-
cord-006229-7yoilsho	2275	9	and	and	CC
cord-006229-7yoilsho	2275	10	positive	positive	JJ
cord-006229-7yoilsho	2275	11	chronotropic	chronotropic	JJ
cord-006229-7yoilsho	2275	12	effects	effect	NNS
cord-006229-7yoilsho	2275	13	(	(	-LRB-
cord-006229-7yoilsho	2275	14	PCE	pce	NN
cord-006229-7yoilsho	2275	15	)	)	-RRB-
cord-006229-7yoilsho	2275	16	in	in	IN
cord-006229-7yoilsho	2275	17	left	left	JJ
cord-006229-7yoilsho	2275	18	and	and	CC
cord-006229-7yoilsho	2275	19	right	right	JJ
cord-006229-7yoilsho	2275	20	atria	atria	NN
cord-006229-7yoilsho	2275	21	of	of	IN
cord-006229-7yoilsho	2275	22	TG	TG	NNP
cord-006229-7yoilsho	2275	23	mice	mouse	NNS
cord-006229-7yoilsho	2275	24	,	,	,
cord-006229-7yoilsho	2275	25	respectively	respectively	RB
cord-006229-7yoilsho	2275	26	,	,	,
cord-006229-7yoilsho	2275	27	but	but	CC
cord-006229-7yoilsho	2275	28	not	not	RB
cord-006229-7yoilsho	2275	29	in	in	IN
cord-006229-7yoilsho	2275	30	WT	WT	NNP
cord-006229-7yoilsho	2275	31	.	.	.
cord-006229-7yoilsho	2276	1	Interestingly	interestingly	RB
cord-006229-7yoilsho	2276	2	,	,	,
cord-006229-7yoilsho	2276	3	the	the	DT
cord-006229-7yoilsho	2276	4	inhibitor	inhibitor	NN
cord-006229-7yoilsho	2276	5	of	of	IN
cord-006229-7yoilsho	2276	6	histamine	histamine	NN
cord-006229-7yoilsho	2276	7	oxidation	oxidation	NN
cord-006229-7yoilsho	2276	8	,	,	,
cord-006229-7yoilsho	2276	9	aminoguanidine	aminoguanidine	NNP
cord-006229-7yoilsho	2276	10	(	(	-LRB-
cord-006229-7yoilsho	2276	11	1	1	CD
cord-006229-7yoilsho	2276	12	mM	mm	CD
cord-006229-7yoilsho	2276	13	)	)	-RRB-
cord-006229-7yoilsho	2276	14	,	,	,
cord-006229-7yoilsho	2276	15	shifted	shift	VBD
cord-006229-7yoilsho	2276	16	the	the	DT
cord-006229-7yoilsho	2276	17	concentration	concentration	NN
cord-006229-7yoilsho	2276	18	response	response	NN
cord-006229-7yoilsho	2276	19	curves	curve	NNS
cord-006229-7yoilsho	2276	20	for	for	IN
cord-006229-7yoilsho	2276	21	the	the	DT
cord-006229-7yoilsho	2276	22	PIE	pie	NN
cord-006229-7yoilsho	2276	23	of	of	IN
cord-006229-7yoilsho	2276	24	histamine	histamine	NN
cord-006229-7yoilsho	2276	25	from	from	IN
cord-006229-7yoilsho	2276	26	EC	EC	NNP
cord-006229-7yoilsho	2276	27	50	50	CD
cord-006229-7yoilsho	2276	28	=	=	SYM
cord-006229-7yoilsho	2276	29	110	110	CD
cord-006229-7yoilsho	2276	30	nM	nm	NN
cord-006229-7yoilsho	2276	31	to	to	IN
cord-006229-7yoilsho	2276	32	37	37	CD
cord-006229-7yoilsho	2276	33	nM	nm	NN
cord-006229-7yoilsho	2276	34	(	(	-LRB-
cord-006229-7yoilsho	2276	35	p<0.05	p<0.05	CD
cord-006229-7yoilsho	2276	36	)	)	-RRB-
cord-006229-7yoilsho	2276	37	.	.	.
cord-006229-7yoilsho	2277	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	2277	2	,	,	,
cord-006229-7yoilsho	2277	3	the	the	DT
cord-006229-7yoilsho	2277	4	unspecific	unspecific	JJ
cord-006229-7yoilsho	2277	5	inhibitor	inhibitor	NN
cord-006229-7yoilsho	2277	6	of	of	IN
cord-006229-7yoilsho	2277	7	mono	mono	NN
cord-006229-7yoilsho	2277	8	amine	amine	NN
cord-006229-7yoilsho	2277	9	oxidase	oxidase	NN
cord-006229-7yoilsho	2277	10	,	,	,
cord-006229-7yoilsho	2277	11	tranylcypromine	tranylcypromine	NNP
cord-006229-7yoilsho	2277	12	(	(	-LRB-
cord-006229-7yoilsho	2277	13	10	10	CD
cord-006229-7yoilsho	2277	14	µM	µM	NNP
cord-006229-7yoilsho	2277	15	)	)	-RRB-
cord-006229-7yoilsho	2277	16	,	,	,
cord-006229-7yoilsho	2277	17	shifted	shift	VBD
cord-006229-7yoilsho	2277	18	the	the	DT
cord-006229-7yoilsho	2277	19	PIE	pie	NN
cord-006229-7yoilsho	2277	20	of	of	IN
cord-006229-7yoilsho	2277	21	histamine	histamine	NN
cord-006229-7yoilsho	2277	22	from	from	IN
cord-006229-7yoilsho	2277	23	EC	EC	NNP
cord-006229-7yoilsho	2277	24	50	50	CD
cord-006229-7yoilsho	2277	25	=	=	SYM
cord-006229-7yoilsho	2277	26	70	70	CD
cord-006229-7yoilsho	2277	27	nM	nm	NN
cord-006229-7yoilsho	2277	28	to	to	IN
cord-006229-7yoilsho	2277	29	38	38	CD
cord-006229-7yoilsho	2277	30	nM	nm	CD
cord-006229-7yoilsho	2277	31	and	and	CC
cord-006229-7yoilsho	2277	32	increased	increase	VBD
cord-006229-7yoilsho	2277	33	the	the	DT
cord-006229-7yoilsho	2277	34	efficacy	efficacy	NN
cord-006229-7yoilsho	2277	35	of	of	IN
cord-006229-7yoilsho	2277	36	histamine	histamine	NN
cord-006229-7yoilsho	2277	37	for	for	IN
cord-006229-7yoilsho	2277	38	the	the	DT
cord-006229-7yoilsho	2277	39	PIE	pie	NN
cord-006229-7yoilsho	2277	40	(	(	-LRB-
cord-006229-7yoilsho	2277	41	p<0.05	p<0.05	CD
cord-006229-7yoilsho	2277	42	)	)	-RRB-
cord-006229-7yoilsho	2277	43	.	.	.
cord-006229-7yoilsho	2278	1	These	these	DT
cord-006229-7yoilsho	2278	2	data	datum	NNS
cord-006229-7yoilsho	2278	3	indicate	indicate	VBP
cord-006229-7yoilsho	2278	4	that	that	IN
cord-006229-7yoilsho	2278	5	exogenously	exogenously	RB
cord-006229-7yoilsho	2278	6	applied	apply	VBN
cord-006229-7yoilsho	2278	7	histamine	histamine	NN
cord-006229-7yoilsho	2278	8	is	be	VBZ
cord-006229-7yoilsho	2278	9	subject	subject	JJ
cord-006229-7yoilsho	2278	10	to	to	IN
cord-006229-7yoilsho	2278	11	degradation	degradation	NN
cord-006229-7yoilsho	2278	12	in	in	IN
cord-006229-7yoilsho	2278	13	the	the	DT
cord-006229-7yoilsho	2278	14	mouse	mouse	NN
cord-006229-7yoilsho	2278	15	heart	heart	NN
cord-006229-7yoilsho	2278	16	by	by	IN
cord-006229-7yoilsho	2278	17	two	two	CD
cord-006229-7yoilsho	2278	18	different	different	JJ
cord-006229-7yoilsho	2278	19	pathways	pathway	NNS
cord-006229-7yoilsho	2278	20	namely	namely	RB
cord-006229-7yoilsho	2278	21	via	via	IN
cord-006229-7yoilsho	2278	22	diaminoxidase	diaminoxidase	NN
cord-006229-7yoilsho	2278	23	and	and	CC
cord-006229-7yoilsho	2278	24	mono	mono	NN
cord-006229-7yoilsho	2278	25	amine	amine	NN
cord-006229-7yoilsho	2278	26	oxidase	oxidase	NN
cord-006229-7yoilsho	2278	27	.	.	.
cord-006229-7yoilsho	2279	1	Drugs	drug	NNS
cord-006229-7yoilsho	2279	2	that	that	WDT
cord-006229-7yoilsho	2279	3	inhibit	inhibit	VBP
cord-006229-7yoilsho	2279	4	these	these	DT
cord-006229-7yoilsho	2279	5	s	s	POS
cord-006229-7yoilsho	2279	6	enzymes	enzyme	NNS
cord-006229-7yoilsho	2279	7	could	could	MD
cord-006229-7yoilsho	2279	8	conceivably	conceivably	RB
cord-006229-7yoilsho	2279	9	alter	alter	VB
cord-006229-7yoilsho	2279	10	cardiac	cardiac	JJ
cord-006229-7yoilsho	2279	11	function	function	NN
cord-006229-7yoilsho	2279	12	also	also	RB
cord-006229-7yoilsho	2279	13	in	in	IN
cord-006229-7yoilsho	2279	14	the	the	DT
cord-006229-7yoilsho	2279	15	human	human	JJ
cord-006229-7yoilsho	2279	16	heart	heart	NN
cord-006229-7yoilsho	2279	17	.	.	.
cord-006229-7yoilsho	2280	1	Protein	protein	NN
cord-006229-7yoilsho	2280	2	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	2280	3	by	by	IN
cord-006229-7yoilsho	2280	4	kinases	kinase	NNS
cord-006229-7yoilsho	2280	5	and	and	CC
cord-006229-7yoilsho	2280	6	dephosphorylation	dephosphorylation	NN
cord-006229-7yoilsho	2280	7	by	by	IN
cord-006229-7yoilsho	2280	8	protein	protein	NN
cord-006229-7yoilsho	2280	9	phosphatases	phosphatase	NNS
cord-006229-7yoilsho	2280	10	has	have	VBZ
cord-006229-7yoilsho	2280	11	a	a	DT
cord-006229-7yoilsho	2280	12	crucial	crucial	JJ
cord-006229-7yoilsho	2280	13	function	function	NN
cord-006229-7yoilsho	2280	14	in	in	IN
cord-006229-7yoilsho	2280	15	cell	cell	NN
cord-006229-7yoilsho	2280	16	signal	signal	NN
cord-006229-7yoilsho	2280	17	cascades	cascade	NNS
cord-006229-7yoilsho	2280	18	.	.	.
cord-006229-7yoilsho	2281	1	It	-PRON-	PRP
cord-006229-7yoilsho	2281	2	has	have	VBZ
cord-006229-7yoilsho	2281	3	been	be	VBN
cord-006229-7yoilsho	2281	4	shown	show	VBN
cord-006229-7yoilsho	2281	5	that	that	IN
cord-006229-7yoilsho	2281	6	cardiomyocyte	cardiomyocyte	DT
cord-006229-7yoilsho	2281	7	specific	specific	JJ
cord-006229-7yoilsho	2281	8	overexpression	overexpression	NN
cord-006229-7yoilsho	2281	9	of	of	IN
cord-006229-7yoilsho	2281	10	serine	serine	NN
cord-006229-7yoilsho	2281	11	/threonine	/threonine	NNP
cord-006229-7yoilsho	2281	12	protein	protein	NN
cord-006229-7yoilsho	2281	13	phosphatases	phosphatase	NNS
cord-006229-7yoilsho	2281	14	PP1	PP1	NNP
cord-006229-7yoilsho	2281	15	,	,	,
cord-006229-7yoilsho	2281	16	PP2A	PP2A	NNP
cord-006229-7yoilsho	2281	17	,	,	,
cord-006229-7yoilsho	2281	18	PP2B	PP2B	NNS
cord-006229-7yoilsho	2281	19	(	(	-LRB-
cord-006229-7yoilsho	2281	20	Calcineurin	Calcineurin	NNP
cord-006229-7yoilsho	2281	21	)	)	-RRB-
cord-006229-7yoilsho	2281	22	and	and	CC
cord-006229-7yoilsho	2281	23	PP5	pp5	NN
cord-006229-7yoilsho	2281	24	in	in	IN
cord-006229-7yoilsho	2281	25	mice	mouse	NNS
cord-006229-7yoilsho	2281	26	leads	lead	VBZ
cord-006229-7yoilsho	2281	27	to	to	IN
cord-006229-7yoilsho	2281	28	cardiac	cardiac	JJ
cord-006229-7yoilsho	2281	29	hypertrophy	hypertrophy	NN
cord-006229-7yoilsho	2281	30	and	and	CC
cord-006229-7yoilsho	2281	31	alters	alter	VBZ
cord-006229-7yoilsho	2281	32	cardiac	cardiac	JJ
cord-006229-7yoilsho	2281	33	function	function	NN
cord-006229-7yoilsho	2281	34	.	.	.
cord-006229-7yoilsho	2282	1	To	to	TO
cord-006229-7yoilsho	2282	2	examine	examine	VB
cord-006229-7yoilsho	2282	3	the	the	DT
cord-006229-7yoilsho	2282	4	function	function	NN
cord-006229-7yoilsho	2282	5	of	of	IN
cord-006229-7yoilsho	2282	6	another	another	DT
cord-006229-7yoilsho	2282	7	important	important	JJ
cord-006229-7yoilsho	2282	8	protein	protein	NN
cord-006229-7yoilsho	2282	9	phosphatase	phosphatase	NN
cord-006229-7yoilsho	2282	10	in	in	IN
cord-006229-7yoilsho	2282	11	the	the	DT
cord-006229-7yoilsho	2282	12	heart	heart	NN
cord-006229-7yoilsho	2282	13	we	-PRON-	PRP
cord-006229-7yoilsho	2282	14	established	establish	VBD
cord-006229-7yoilsho	2282	15	a	a	DT
cord-006229-7yoilsho	2282	16	mouse	mouse	NN
cord-006229-7yoilsho	2282	17	model	model	NN
cord-006229-7yoilsho	2282	18	overexpressing	overexpresse	VBG
cord-006229-7yoilsho	2282	19	protein	protein	NN
cord-006229-7yoilsho	2282	20	phosphatase	phosphatase	NN
cord-006229-7yoilsho	2282	21	2Cβ	2cβ	NN
cord-006229-7yoilsho	2282	22	(	(	-LRB-
cord-006229-7yoilsho	2282	23	PP2Cβ	PP2Cβ	NNP
cord-006229-7yoilsho	2282	24	)	)	-RRB-
cord-006229-7yoilsho	2282	25	under	under	IN
cord-006229-7yoilsho	2282	26	control	control	NN
cord-006229-7yoilsho	2282	27	of	of	IN
cord-006229-7yoilsho	2282	28	the	the	DT
cord-006229-7yoilsho	2282	29	α	α	NN
cord-006229-7yoilsho	2282	30	-	-	HYPH
cord-006229-7yoilsho	2282	31	myosin	myosin	NN
cord-006229-7yoilsho	2282	32	heavy	heavy	JJ
cord-006229-7yoilsho	2282	33	chain	chain	NN
cord-006229-7yoilsho	2282	34	promoter	promoter	NN
cord-006229-7yoilsho	2282	35	.	.	.
cord-006229-7yoilsho	2283	1	Cardiac	cardiac	JJ
cord-006229-7yoilsho	2283	2	overexpression	overexpression	NN
cord-006229-7yoilsho	2283	3	was	be	VBD
cord-006229-7yoilsho	2283	4	demonstrated	demonstrate	VBN
cord-006229-7yoilsho	2283	5	by	by	IN
cord-006229-7yoilsho	2283	6	Western	western	JJ
cord-006229-7yoilsho	2283	7	blotting	blotting	NN
cord-006229-7yoilsho	2283	8	.	.	.
cord-006229-7yoilsho	2284	1	Like	like	IN
cord-006229-7yoilsho	2284	2	other	other	JJ
cord-006229-7yoilsho	2284	3	serine	serine	NN
cord-006229-7yoilsho	2284	4	/	/	SYM
cord-006229-7yoilsho	2284	5	threonine	threonine	NN
cord-006229-7yoilsho	2284	6	phosphatases	phosphatase	NNS
cord-006229-7yoilsho	2284	7	,	,	,
cord-006229-7yoilsho	2284	8	PP2Cβ	PP2Cβ	NNP
cord-006229-7yoilsho	2284	9	can	can	MD
cord-006229-7yoilsho	2284	10	lead	lead	VB
cord-006229-7yoilsho	2284	11	to	to	IN
cord-006229-7yoilsho	2284	12	cardiac	cardiac	JJ
cord-006229-7yoilsho	2284	13	hypertrophy	hypertrophy	NN
cord-006229-7yoilsho	2284	14	.	.	.
cord-006229-7yoilsho	2285	1	In	in	IN
cord-006229-7yoilsho	2285	2	transgenic	transgenic	JJ
cord-006229-7yoilsho	2285	3	mice	mouse	NNS
cord-006229-7yoilsho	2285	4	(	(	-LRB-
cord-006229-7yoilsho	2285	5	TG	TG	NNP
cord-006229-7yoilsho	2285	6	)	)	-RRB-
cord-006229-7yoilsho	2285	7	,	,	,
cord-006229-7yoilsho	2285	8	relative	relative	JJ
cord-006229-7yoilsho	2285	9	ventricular	ventricular	JJ
cord-006229-7yoilsho	2285	10	weight	weight	NN
cord-006229-7yoilsho	2285	11	was	be	VBD
cord-006229-7yoilsho	2285	12	increased	increase	VBN
cord-006229-7yoilsho	2285	13	(	(	-LRB-
cord-006229-7yoilsho	2285	14	4.24	4.24	CD
cord-006229-7yoilsho	2285	15	±	±	CD
cord-006229-7yoilsho	2285	16	0.14	0.14	CD
cord-006229-7yoilsho	2285	17	mg	mg	NNP
cord-006229-7yoilsho	2285	18	/	/	SYM
cord-006229-7yoilsho	2285	19	g	g	NN
cord-006229-7yoilsho	2285	20	)	)	-RRB-
cord-006229-7yoilsho	2285	21	compared	compare	VBN
cord-006229-7yoilsho	2285	22	to	to	IN
cord-006229-7yoilsho	2285	23	wild	wild	JJ
cord-006229-7yoilsho	2285	24	type	type	NN
cord-006229-7yoilsho	2285	25	(	(	-LRB-
cord-006229-7yoilsho	2285	26	WT	WT	NNP
cord-006229-7yoilsho	2285	27	)	)	-RRB-
cord-006229-7yoilsho	2285	28	littermates	littermates	NNP
cord-006229-7yoilsho	2285	29	(	(	-LRB-
cord-006229-7yoilsho	2285	30	3.78	3.78	CD
cord-006229-7yoilsho	2285	31	±	±	CD
cord-006229-7yoilsho	2285	32	0.20	0.20	CD
cord-006229-7yoilsho	2285	33	mg	mg	NNP
cord-006229-7yoilsho	2285	34	/	/	SYM
cord-006229-7yoilsho	2285	35	g	g	NN
cord-006229-7yoilsho	2285	36	;	;	:
cord-006229-7yoilsho	2285	37	p<0.05	p<0.05	CD
cord-006229-7yoilsho	2285	38	)	)	-RRB-
cord-006229-7yoilsho	2286	1	whereas	whereas	IN
cord-006229-7yoilsho	2286	2	weights	weight	NNS
cord-006229-7yoilsho	2286	3	of	of	IN
cord-006229-7yoilsho	2286	4	right	right	NN
cord-006229-7yoilsho	2286	5	and	and	CC
cord-006229-7yoilsho	2286	6	left	left	JJ
cord-006229-7yoilsho	2286	7	atria	atria	NN
cord-006229-7yoilsho	2286	8	were	be	VBD
cord-006229-7yoilsho	2286	9	unchanged	unchanged	JJ
cord-006229-7yoilsho	2286	10	.	.	.
cord-006229-7yoilsho	2287	1	Therefore	therefore	RB
cord-006229-7yoilsho	2287	2	,	,	,
cord-006229-7yoilsho	2287	3	relative	relative	JJ
cord-006229-7yoilsho	2287	4	heart	heart	NN
cord-006229-7yoilsho	2287	5	weight	weight	NN
cord-006229-7yoilsho	2287	6	was	be	VBD
cord-006229-7yoilsho	2287	7	increased	increase	VBN
cord-006229-7yoilsho	2287	8	in	in	IN
cord-006229-7yoilsho	2287	9	TG	TG	NNP
cord-006229-7yoilsho	2287	10	(	(	-LRB-
cord-006229-7yoilsho	2287	11	4.78	4.78	CD
cord-006229-7yoilsho	2287	12	±	±	CD
cord-006229-7yoilsho	2287	13	0.17	0.17	CD
cord-006229-7yoilsho	2287	14	mg	mg	NNP
cord-006229-7yoilsho	2287	15	/	/	SYM
cord-006229-7yoilsho	2287	16	g	g	NN
cord-006229-7yoilsho	2287	17	)	)	-RRB-
cord-006229-7yoilsho	2287	18	vs.	vs.	FW
cord-006229-7yoilsho	2287	19	WT	WT	NNP
cord-006229-7yoilsho	2287	20	(	(	-LRB-
cord-006229-7yoilsho	2287	21	4.13	4.13	CD
cord-006229-7yoilsho	2287	22	±	±	CD
cord-006229-7yoilsho	2287	23	0.22	0.22	CD
cord-006229-7yoilsho	2287	24	mg	mg	NNP
cord-006229-7yoilsho	2287	25	/	/	SYM
cord-006229-7yoilsho	2287	26	g	g	NN
cord-006229-7yoilsho	2287	27	;	;	:
cord-006229-7yoilsho	2287	28	n=8	n=8	NN
cord-006229-7yoilsho	2287	29	-	-	HYPH
cord-006229-7yoilsho	2287	30	12	12	CD
cord-006229-7yoilsho	2287	31	;	;	:
cord-006229-7yoilsho	2287	32	10	10	CD
cord-006229-7yoilsho	2287	33	-	-	SYM
cord-006229-7yoilsho	2287	34	11	11	CD
cord-006229-7yoilsho	2287	35	months	month	NNS
cord-006229-7yoilsho	2287	36	of	of	IN
cord-006229-7yoilsho	2287	37	age	age	NN
cord-006229-7yoilsho	2287	38	;	;	:
cord-006229-7yoilsho	2287	39	p<0.05	p<0.05	CD
cord-006229-7yoilsho	2287	40	)	)	-RRB-
cord-006229-7yoilsho	2287	41	.	.	.
cord-006229-7yoilsho	2288	1	Left	leave	VBN
cord-006229-7yoilsho	2288	2	ventricular	ventricular	JJ
cord-006229-7yoilsho	2288	3	function	function	NN
cord-006229-7yoilsho	2288	4	,	,	,
cord-006229-7yoilsho	2288	5	measured	measure	VBN
cord-006229-7yoilsho	2288	6	in	in	IN
cord-006229-7yoilsho	2288	7	vivo	vivo	NN
cord-006229-7yoilsho	2288	8	by	by	IN
cord-006229-7yoilsho	2288	9	echocardiography	echocardiography	NN
cord-006229-7yoilsho	2288	10	under	under	IN
cord-006229-7yoilsho	2288	11	isoflurane	isoflurane	NNP
cord-006229-7yoilsho	2288	12	anesthesia	anesthesia	NNP
cord-006229-7yoilsho	2288	13	was	be	VBD
cord-006229-7yoilsho	2288	14	diminished	diminish	VBN
cord-006229-7yoilsho	2288	15	in	in	IN
cord-006229-7yoilsho	2288	16	TG	TG	NNP
cord-006229-7yoilsho	2288	17	compared	compare	VBN
cord-006229-7yoilsho	2288	18	to	to	IN
cord-006229-7yoilsho	2288	19	WT	WT	NNP
cord-006229-7yoilsho	2288	20	(	(	-LRB-
cord-006229-7yoilsho	2288	21	ejection	ejection	NN
cord-006229-7yoilsho	2288	22	fraction	fraction	NN
cord-006229-7yoilsho	2288	23	:	:	:
cord-006229-7yoilsho	2289	1	58.33	58.33	CD
cord-006229-7yoilsho	2289	2	±	±	CD
cord-006229-7yoilsho	2289	3	3.16	3.16	CD
cord-006229-7yoilsho	2289	4	%	%	NN
cord-006229-7yoilsho	2289	5	(	(	-LRB-
cord-006229-7yoilsho	2289	6	TG	TG	NNP
cord-006229-7yoilsho	2289	7	)	)	-RRB-
cord-006229-7yoilsho	2289	8	versus	versus	IN
cord-006229-7yoilsho	2289	9	76.94	76.94	CD
cord-006229-7yoilsho	2289	10	±	±	CD
cord-006229-7yoilsho	2289	11	0.92	0.92	CD
cord-006229-7yoilsho	2289	12	%	%	NN
cord-006229-7yoilsho	2289	13	(	(	-LRB-
cord-006229-7yoilsho	2289	14	WT	WT	NNP
cord-006229-7yoilsho	2289	15	)	)	-RRB-
cord-006229-7yoilsho	2289	16	;	;	:
cord-006229-7yoilsho	2289	17	n=12	n=12	NNP
cord-006229-7yoilsho	2289	18	-	-	HYPH
cord-006229-7yoilsho	2289	19	16	16	CD
cord-006229-7yoilsho	2289	20	;	;	:
cord-006229-7yoilsho	2289	21	8	8	CD
cord-006229-7yoilsho	2289	22	-	-	SYM
cord-006229-7yoilsho	2289	23	11	11	CD
cord-006229-7yoilsho	2289	24	months	month	NNS
cord-006229-7yoilsho	2289	25	;	;	:
cord-006229-7yoilsho	2289	26	p<0.05	p<0.05	JJ
cord-006229-7yoilsho	2289	27	and	and	CC
cord-006229-7yoilsho	2289	28	fractional	fractional	JJ
cord-006229-7yoilsho	2289	29	shortening	shortening	NN
cord-006229-7yoilsho	2289	30	:	:	:
cord-006229-7yoilsho	2289	31	30.84	30.84	CD
cord-006229-7yoilsho	2289	32	±	±	CD
cord-006229-7yoilsho	2289	33	2.02	2.02	CD
cord-006229-7yoilsho	2289	34	%	%	NN
cord-006229-7yoilsho	2289	35	(	(	-LRB-
cord-006229-7yoilsho	2289	36	TG	TG	NNP
cord-006229-7yoilsho	2289	37	)	)	-RRB-
cord-006229-7yoilsho	2289	38	versus	versus	IN
cord-006229-7yoilsho	2289	39	44.94	44.94	CD
cord-006229-7yoilsho	2289	40	±	±	CD
cord-006229-7yoilsho	2289	41	0.87	0.87	CD
cord-006229-7yoilsho	2289	42	%	%	NN
cord-006229-7yoilsho	2289	43	(	(	-LRB-
cord-006229-7yoilsho	2289	44	WT	WT	NNP
cord-006229-7yoilsho	2289	45	)	)	-RRB-
cord-006229-7yoilsho	2289	46	;	;	:
cord-006229-7yoilsho	2289	47	n=12	n=12	NNP
cord-006229-7yoilsho	2289	48	-	-	HYPH
cord-006229-7yoilsho	2289	49	16	16	CD
cord-006229-7yoilsho	2289	50	;	;	:
cord-006229-7yoilsho	2289	51	8	8	CD
cord-006229-7yoilsho	2289	52	-	-	SYM
cord-006229-7yoilsho	2289	53	11	11	CD
cord-006229-7yoilsho	2289	54	months	month	NNS
cord-006229-7yoilsho	2289	55	;	;	:
cord-006229-7yoilsho	2289	56	p<0.05	p<0.05	CD
cord-006229-7yoilsho	2289	57	)	)	-RRB-
cord-006229-7yoilsho	2289	58	.	.	.
cord-006229-7yoilsho	2290	1	The	the	DT
cord-006229-7yoilsho	2290	2	left	left	JJ
cord-006229-7yoilsho	2290	3	ventricle	ventricle	NN
cord-006229-7yoilsho	2290	4	was	be	VBD
cord-006229-7yoilsho	2290	5	dilated	dilate	VBN
cord-006229-7yoilsho	2291	1	(	(	-LRB-
cord-006229-7yoilsho	2291	2	systolic	systolic	NNP
cord-006229-7yoilsho	2291	3	diameter	diameter	NN
cord-006229-7yoilsho	2291	4	:	:	:
cord-006229-7yoilsho	2291	5	2.78	2.78	CD
cord-006229-7yoilsho	2291	6	±	±	CD
cord-006229-7yoilsho	2291	7	0.21	0.21	CD
cord-006229-7yoilsho	2291	8	mm	mm	NNP
cord-006229-7yoilsho	2291	9	(	(	-LRB-
cord-006229-7yoilsho	2291	10	TG	TG	NNP
cord-006229-7yoilsho	2291	11	)	)	-RRB-
cord-006229-7yoilsho	2291	12	versus	versus	IN
cord-006229-7yoilsho	2291	13	1.84	1.84	CD
cord-006229-7yoilsho	2291	14	±	±	CD
cord-006229-7yoilsho	2291	15	0.06	0.06	CD
cord-006229-7yoilsho	2291	16	mm	mm	NNP
cord-006229-7yoilsho	2291	17	(	(	-LRB-
cord-006229-7yoilsho	2291	18	WT	WT	NNP
cord-006229-7yoilsho	2291	19	)	)	-RRB-
cord-006229-7yoilsho	2291	20	;	;	:
cord-006229-7yoilsho	2291	21	n=12	n=12	NNP
cord-006229-7yoilsho	2291	22	-	-	HYPH
cord-006229-7yoilsho	2291	23	16	16	CD
cord-006229-7yoilsho	2291	24	;	;	:
cord-006229-7yoilsho	2291	25	8	8	CD
cord-006229-7yoilsho	2291	26	-	-	SYM
cord-006229-7yoilsho	2291	27	11	11	CD
cord-006229-7yoilsho	2291	28	months	month	NNS
cord-006229-7yoilsho	2291	29	;	;	:
cord-006229-7yoilsho	2291	30	p<0.05	p<0.05	CD
cord-006229-7yoilsho	2291	31	;	;	:
cord-006229-7yoilsho	2291	32	diastolic	diastolic	JJ
cord-006229-7yoilsho	2291	33	diameter	diameter	NN
cord-006229-7yoilsho	2291	34	:	:	:
cord-006229-7yoilsho	2291	35	3.97±	3.97±	NNP
cord-006229-7yoilsho	2291	36	0.19	0.19	CD
cord-006229-7yoilsho	2291	37	mm	mm	NNP
cord-006229-7yoilsho	2291	38	(	(	-LRB-
cord-006229-7yoilsho	2291	39	TG	TG	NNP
cord-006229-7yoilsho	2291	40	)	)	-RRB-
cord-006229-7yoilsho	2291	41	versus	versus	IN
cord-006229-7yoilsho	2291	42	3.33	3.33	CD
cord-006229-7yoilsho	2291	43	±	±	CD
cord-006229-7yoilsho	2291	44	0.07	0.07	CD
cord-006229-7yoilsho	2291	45	mm	mm	NNP
cord-006229-7yoilsho	2291	46	(	(	-LRB-
cord-006229-7yoilsho	2291	47	WT	WT	NNP
cord-006229-7yoilsho	2291	48	)	)	-RRB-
cord-006229-7yoilsho	2291	49	;	;	:
cord-006229-7yoilsho	2291	50	n=12	n=12	NNP
cord-006229-7yoilsho	2291	51	-	-	HYPH
cord-006229-7yoilsho	2291	52	16	16	CD
cord-006229-7yoilsho	2291	53	;	;	:
cord-006229-7yoilsho	2291	54	8	8	CD
cord-006229-7yoilsho	2291	55	-	-	SYM
cord-006229-7yoilsho	2291	56	11	11	CD
cord-006229-7yoilsho	2291	57	months	month	NNS
cord-006229-7yoilsho	2291	58	;	;	:
cord-006229-7yoilsho	2291	59	p<0.05	p<0.05	CD
cord-006229-7yoilsho	2291	60	)	)	-RRB-
cord-006229-7yoilsho	2291	61	.	.	.
cord-006229-7yoilsho	2292	1	In	in	IN
cord-006229-7yoilsho	2292	2	contrast	contrast	NN
cord-006229-7yoilsho	2292	3	,	,	,
cord-006229-7yoilsho	2292	4	atrial	atrial	JJ
cord-006229-7yoilsho	2292	5	function	function	NN
cord-006229-7yoilsho	2292	6	measured	measure	VBN
cord-006229-7yoilsho	2292	7	as	as	IN
cord-006229-7yoilsho	2292	8	response	response	NN
cord-006229-7yoilsho	2292	9	to	to	IN
cord-006229-7yoilsho	2292	10	β	β	NN
cord-006229-7yoilsho	2292	11	-	-	HYPH
cord-006229-7yoilsho	2292	12	adrenergic	adrenergic	JJ
cord-006229-7yoilsho	2292	13	stimulation	stimulation	NN
cord-006229-7yoilsho	2292	14	in	in	IN
cord-006229-7yoilsho	2292	15	isolated	isolated	JJ
cord-006229-7yoilsho	2292	16	left	left	JJ
cord-006229-7yoilsho	2292	17	and	and	CC
cord-006229-7yoilsho	2292	18	right	right	JJ
cord-006229-7yoilsho	2292	19	atrial	atrial	JJ
cord-006229-7yoilsho	2292	20	preparations	preparation	NNS
cord-006229-7yoilsho	2292	21	was	be	VBD
cord-006229-7yoilsho	2292	22	unchanged	unchanged	JJ
cord-006229-7yoilsho	2292	23	in	in	IN
cord-006229-7yoilsho	2292	24	TG	TG	NNP
cord-006229-7yoilsho	2292	25	vs.	vs.	IN
cord-006229-7yoilsho	2292	26	WT	WT	NNP
cord-006229-7yoilsho	2292	27	.	.	.
cord-006229-7yoilsho	2293	1	In	in	IN
cord-006229-7yoilsho	2293	2	summary	summary	NN
cord-006229-7yoilsho	2293	3	,	,	,
cord-006229-7yoilsho	2293	4	our	-PRON-	PRP$
cord-006229-7yoilsho	2293	5	results	result	NNS
cord-006229-7yoilsho	2293	6	indicate	indicate	VBP
cord-006229-7yoilsho	2293	7	that	that	IN
cord-006229-7yoilsho	2293	8	PP2Cβ	PP2Cβ	NNP
cord-006229-7yoilsho	2293	9	overexpression	overexpression	NN
cord-006229-7yoilsho	2293	10	can	can	MD
cord-006229-7yoilsho	2293	11	lead	lead	VB
cord-006229-7yoilsho	2293	12	to	to	IN
cord-006229-7yoilsho	2293	13	ventricular	ventricular	JJ
cord-006229-7yoilsho	2293	14	dysfunction	dysfunction	NN
cord-006229-7yoilsho	2293	15	and	and	CC
cord-006229-7yoilsho	2293	16	hypertrophy	hypertrophy	NN
cord-006229-7yoilsho	2293	17	.	.	.
cord-006229-7yoilsho	2294	1	The	the	DT
cord-006229-7yoilsho	2294	2	underlying	underlie	VBG
cord-006229-7yoilsho	2294	3	signal	signal	NN
cord-006229-7yoilsho	2294	4	transduction	transduction	NN
cord-006229-7yoilsho	2294	5	pathways	pathway	NNS
cord-006229-7yoilsho	2294	6	need	need	VBP
cord-006229-7yoilsho	2294	7	to	to	TO
cord-006229-7yoilsho	2294	8	be	be	VB
cord-006229-7yoilsho	2294	9	elucidated	elucidate	VBN
cord-006229-7yoilsho	2294	10	.	.	.
cord-006229-7yoilsho	2295	1	The	the	DT
cord-006229-7yoilsho	2295	2	Insulin	Insulin	NNP
cord-006229-7yoilsho	2295	3	-	-	HYPH
cord-006229-7yoilsho	2295	4	like	like	JJ
cord-006229-7yoilsho	2295	5	growth	growth	NN
cord-006229-7yoilsho	2295	6	factor	factor	NN
cord-006229-7yoilsho	2295	7	binding	bind	VBG
cord-006229-7yoilsho	2295	8	protein	protein	NN
cord-006229-7yoilsho	2295	9	5	5	CD
cord-006229-7yoilsho	2295	10	(	(	-LRB-
cord-006229-7yoilsho	2295	11	IGFBP5	IGFBP5	NNP
cord-006229-7yoilsho	2295	12	)	)	-RRB-
cord-006229-7yoilsho	2296	1	-a	-a	:
cord-006229-7yoilsho	2296	2	potential	potential	JJ
cord-006229-7yoilsho	2296	3	developmental	developmental	JJ
cord-006229-7yoilsho	2296	4	gene	gene	NN
cord-006229-7yoilsho	2296	5	is	be	VBZ
cord-006229-7yoilsho	2296	6	regulated	regulate	VBN
cord-006229-7yoilsho	2296	7	upon	upon	IN
cord-006229-7yoilsho	2296	8	cardiac	cardiac	JJ
cord-006229-7yoilsho	2296	9	stress	stress	NN
cord-006229-7yoilsho	2296	10	M.	M.	NNP
cord-006229-7yoilsho	2296	11	Wölfer	Wölfer	NNP
cord-006229-7yoilsho	2296	12	Background	Background	NNP
cord-006229-7yoilsho	2296	13	:	:	:
cord-006229-7yoilsho	2296	14	Cardiac	cardiac	JJ
cord-006229-7yoilsho	2296	15	remodeling	remodeling	NN
cord-006229-7yoilsho	2296	16	is	be	VBZ
cord-006229-7yoilsho	2296	17	a	a	DT
cord-006229-7yoilsho	2296	18	complex	complex	JJ
cord-006229-7yoilsho	2296	19	biological	biological	JJ
cord-006229-7yoilsho	2296	20	adaptation	adaptation	NN
cord-006229-7yoilsho	2296	21	process	process	NN
cord-006229-7yoilsho	2296	22	of	of	IN
cord-006229-7yoilsho	2296	23	the	the	DT
cord-006229-7yoilsho	2296	24	failing	fail	VBG
cord-006229-7yoilsho	2296	25	heart	heart	NN
cord-006229-7yoilsho	2296	26	accompanied	accompany	VBN
cord-006229-7yoilsho	2296	27	by	by	IN
cord-006229-7yoilsho	2296	28	a	a	DT
cord-006229-7yoilsho	2296	29	re	re	NN
cord-006229-7yoilsho	2296	30	-	-	NN
cord-006229-7yoilsho	2296	31	activation	activation	NN
cord-006229-7yoilsho	2296	32	of	of	IN
cord-006229-7yoilsho	2296	33	embryonic	embryonic	JJ
cord-006229-7yoilsho	2296	34	gene	gene	NN
cord-006229-7yoilsho	2296	35	expression	expression	NN
cord-006229-7yoilsho	2296	36	,	,	,
cord-006229-7yoilsho	2296	37	which	which	WDT
cord-006229-7yoilsho	2296	38	so	so	RB
cord-006229-7yoilsho	2296	39	far	far	RB
cord-006229-7yoilsho	2296	40	has	have	VBZ
cord-006229-7yoilsho	2296	41	unclear	unclear	JJ
cord-006229-7yoilsho	2296	42	pathophysiological	pathophysiological	JJ
cord-006229-7yoilsho	2296	43	relevance	relevance	NN
cord-006229-7yoilsho	2296	44	.	.	.
cord-006229-7yoilsho	2297	1	We	-PRON-	PRP
cord-006229-7yoilsho	2297	2	and	and	CC
cord-006229-7yoilsho	2297	3	others	other	NNS
cord-006229-7yoilsho	2297	4	showed	show	VBD
cord-006229-7yoilsho	2297	5	that	that	IN
cord-006229-7yoilsho	2297	6	Insulin	Insulin	NNP
cord-006229-7yoilsho	2297	7	-	-	HYPH
cord-006229-7yoilsho	2297	8	like	like	JJ
cord-006229-7yoilsho	2297	9	growth	growth	NN
cord-006229-7yoilsho	2297	10	factor	factor	NN
cord-006229-7yoilsho	2297	11	binding	bind	VBG
cord-006229-7yoilsho	2297	12	protein	protein	NN
cord-006229-7yoilsho	2297	13	5	5	CD
cord-006229-7yoilsho	2297	14	(	(	-LRB-
cord-006229-7yoilsho	2297	15	IGFBP5	IGFBP5	NNP
cord-006229-7yoilsho	2297	16	)	)	-RRB-
cord-006229-7yoilsho	2297	17	is	be	VBZ
cord-006229-7yoilsho	2297	18	expressed	express	VBN
cord-006229-7yoilsho	2297	19	in	in	IN
cord-006229-7yoilsho	2297	20	the	the	DT
cord-006229-7yoilsho	2297	21	early	early	JJ
cord-006229-7yoilsho	2297	22	pre	pre	JJ
cord-006229-7yoilsho	2297	23	-	-	JJ
cord-006229-7yoilsho	2297	24	cardiac	cardiac	JJ
cord-006229-7yoilsho	2297	25	region	region	NN
cord-006229-7yoilsho	2297	26	in	in	IN
cord-006229-7yoilsho	2297	27	mouse	mouse	NN
cord-006229-7yoilsho	2297	28	embryos	embryo	NNS
cord-006229-7yoilsho	2297	29	and	and	CC
cord-006229-7yoilsho	2297	30	its	-PRON-	PRP$
cord-006229-7yoilsho	2297	31	up	up	JJ
cord-006229-7yoilsho	2297	32	-	-	HYPH
cord-006229-7yoilsho	2297	33	regulation	regulation	NN
cord-006229-7yoilsho	2297	34	impairs	impair	VBZ
cord-006229-7yoilsho	2297	35	cardiac	cardiac	JJ
cord-006229-7yoilsho	2297	36	progenitor	progenitor	NN
cord-006229-7yoilsho	2297	37	differentiation	differentiation	NN
cord-006229-7yoilsho	2297	38	.	.	.
cord-006229-7yoilsho	2298	1	IGFBP5	IGFBP5	NNP
cord-006229-7yoilsho	2298	2	functions	function	VBZ
cord-006229-7yoilsho	2298	3	as	as	IN
cord-006229-7yoilsho	2298	4	an	an	DT
cord-006229-7yoilsho	2298	5	extracellular	extracellular	JJ
cord-006229-7yoilsho	2298	6	growth	growth	NN
cord-006229-7yoilsho	2298	7	factor	factor	NN
cord-006229-7yoilsho	2298	8	binding	bind	VBG
cord-006229-7yoilsho	2298	9	protein	protein	NN
cord-006229-7yoilsho	2298	10	for	for	IN
cord-006229-7yoilsho	2298	11	IGF	IGF	NNP
cord-006229-7yoilsho	2298	12	and	and	CC
cord-006229-7yoilsho	2298	13	also	also	RB
cord-006229-7yoilsho	2298	14	has	have	VBZ
cord-006229-7yoilsho	2298	15	IGFindependent	igfindependent	NN
cord-006229-7yoilsho	2298	16	activities	activity	NNS
cord-006229-7yoilsho	2298	17	.	.	.
cord-006229-7yoilsho	2299	1	The	the	DT
cord-006229-7yoilsho	2299	2	role	role	NN
cord-006229-7yoilsho	2299	3	of	of	IN
cord-006229-7yoilsho	2299	4	this	this	DT
cord-006229-7yoilsho	2299	5	factor	factor	NN
cord-006229-7yoilsho	2299	6	in	in	IN
cord-006229-7yoilsho	2299	7	the	the	DT
cord-006229-7yoilsho	2299	8	context	context	NN
cord-006229-7yoilsho	2299	9	of	of	IN
cord-006229-7yoilsho	2299	10	cardiac	cardiac	JJ
cord-006229-7yoilsho	2299	11	remodeling	remodeling	NN
cord-006229-7yoilsho	2299	12	is	be	VBZ
cord-006229-7yoilsho	2299	13	still	still	RB
cord-006229-7yoilsho	2299	14	unknown	unknown	JJ
cord-006229-7yoilsho	2299	15	.	.	.
cord-006229-7yoilsho	2300	1	The	the	DT
cord-006229-7yoilsho	2300	2	aim	aim	NN
cord-006229-7yoilsho	2300	3	of	of	IN
cord-006229-7yoilsho	2300	4	this	this	DT
cord-006229-7yoilsho	2300	5	study	study	NN
cord-006229-7yoilsho	2300	6	was	be	VBD
cord-006229-7yoilsho	2300	7	to	to	TO
cord-006229-7yoilsho	2300	8	investigate	investigate	VB
cord-006229-7yoilsho	2300	9	the	the	DT
cord-006229-7yoilsho	2300	10	relevance	relevance	NN
cord-006229-7yoilsho	2300	11	of	of	IN
cord-006229-7yoilsho	2300	12	IGFBP5	IGFBP5	NNS
cord-006229-7yoilsho	2300	13	in	in	IN
cord-006229-7yoilsho	2300	14	cardiogenesis	cardiogenesis	NN
cord-006229-7yoilsho	2300	15	and	and	CC
cord-006229-7yoilsho	2300	16	cardiac	cardiac	JJ
cord-006229-7yoilsho	2300	17	remodeling	remodeling	NN
cord-006229-7yoilsho	2300	18	and	and	CC
cord-006229-7yoilsho	2300	19	its	-PRON-	PRP$
cord-006229-7yoilsho	2300	20	role	role	NN
cord-006229-7yoilsho	2300	21	as	as	IN
cord-006229-7yoilsho	2300	22	a	a	DT
cord-006229-7yoilsho	2300	23	potential	potential	JJ
cord-006229-7yoilsho	2300	24	target	target	NN
cord-006229-7yoilsho	2300	25	for	for	IN
cord-006229-7yoilsho	2300	26	ameliorating	ameliorate	VBG
cord-006229-7yoilsho	2300	27	stress	stress	NN
cord-006229-7yoilsho	2300	28	-	-	HYPH
cord-006229-7yoilsho	2300	29	induced	induce	VBN
cord-006229-7yoilsho	2300	30	cardiac	cardiac	JJ
cord-006229-7yoilsho	2300	31	remodeling	remodeling	NN
cord-006229-7yoilsho	2300	32	Methods	method	NNS
cord-006229-7yoilsho	2300	33	and	and	CC
cord-006229-7yoilsho	2300	34	Results	result	NNS
cord-006229-7yoilsho	2300	35	:	:	:
cord-006229-7yoilsho	2300	36	We	-PRON-	PRP
cord-006229-7yoilsho	2300	37	investigated	investigate	VBD
cord-006229-7yoilsho	2300	38	the	the	DT
cord-006229-7yoilsho	2300	39	expression	expression	NN
cord-006229-7yoilsho	2300	40	of	of	IN
cord-006229-7yoilsho	2300	41	Igfbp5	Igfbp5	NNP
cord-006229-7yoilsho	2300	42	in	in	IN
cord-006229-7yoilsho	2300	43	murine	murine	JJ
cord-006229-7yoilsho	2300	44	cardiac	cardiac	JJ
cord-006229-7yoilsho	2300	45	tissue	tissue	NN
cord-006229-7yoilsho	2300	46	at	at	IN
cord-006229-7yoilsho	2300	47	different	different	JJ
cord-006229-7yoilsho	2300	48	developmental	developmental	JJ
cord-006229-7yoilsho	2300	49	stages	stage	NNS
cord-006229-7yoilsho	2300	50	by	by	IN
cord-006229-7yoilsho	2300	51	qPCR	qPCR	NNP
cord-006229-7yoilsho	2300	52	normalized	normalize	VBN
cord-006229-7yoilsho	2300	53	to	to	IN
cord-006229-7yoilsho	2300	54	Tpt1	Tpt1	NNP
cord-006229-7yoilsho	2300	55	(	(	-LRB-
cord-006229-7yoilsho	2300	56	Tumor	Tumor	NNP
cord-006229-7yoilsho	2300	57	Protein	Protein	NNP
cord-006229-7yoilsho	2300	58	,	,	,
cord-006229-7yoilsho	2300	59	Translationally	Translationally	NNP
cord-006229-7yoilsho	2300	60	-	-	HYPH
cord-006229-7yoilsho	2300	61	Controlled	control	VBN
cord-006229-7yoilsho	2300	62	1	1	CD
cord-006229-7yoilsho	2300	63	)	)	-RRB-
cord-006229-7yoilsho	2300	64	.	.	.
cord-006229-7yoilsho	2301	1	This	this	DT
cord-006229-7yoilsho	2301	2	analysis	analysis	NN
cord-006229-7yoilsho	2301	3	showed	show	VBD
cord-006229-7yoilsho	2301	4	temporal	temporal	JJ
cord-006229-7yoilsho	2301	5	changes	change	NNS
cord-006229-7yoilsho	2301	6	of	of	IN
cord-006229-7yoilsho	2301	7	cardiac	cardiac	JJ
cord-006229-7yoilsho	2301	8	Igfbp5	Igfbp5	NNP
cord-006229-7yoilsho	2301	9	expression	expression	NN
cord-006229-7yoilsho	2301	10	from	from	IN
cord-006229-7yoilsho	2301	11	developing	develop	VBG
cord-006229-7yoilsho	2301	12	to	to	IN
cord-006229-7yoilsho	2301	13	postnatal	postnatal	JJ
cord-006229-7yoilsho	2301	14	hearts	heart	NNS
cord-006229-7yoilsho	2301	15	,	,	,
cord-006229-7yoilsho	2301	16	where	where	WRB
cord-006229-7yoilsho	2301	17	a	a	DT
cord-006229-7yoilsho	2301	18	high	high	JJ
cord-006229-7yoilsho	2301	19	expression	expression	NN
cord-006229-7yoilsho	2301	20	was	be	VBD
cord-006229-7yoilsho	2301	21	detected	detect	VBN
cord-006229-7yoilsho	2301	22	in	in	IN
cord-006229-7yoilsho	2301	23	early	early	JJ
cord-006229-7yoilsho	2301	24	heart	heart	NN
cord-006229-7yoilsho	2301	25	stages	stage	NNS
cord-006229-7yoilsho	2301	26	,	,	,
cord-006229-7yoilsho	2301	27	which	which	WDT
cord-006229-7yoilsho	2301	28	decreased	decrease	VBD
cord-006229-7yoilsho	2301	29	during	during	IN
cord-006229-7yoilsho	2301	30	cardiac	cardiac	JJ
cord-006229-7yoilsho	2301	31	development	development	NN
cord-006229-7yoilsho	2301	32	and	and	CC
cord-006229-7yoilsho	2301	33	became	become	VBD
cord-006229-7yoilsho	2301	34	low	low	JJ
cord-006229-7yoilsho	2301	35	in	in	IN
cord-006229-7yoilsho	2301	36	the	the	DT
cord-006229-7yoilsho	2301	37	postnatal	postnatal	JJ
cord-006229-7yoilsho	2301	38	heart	heart	NN
cord-006229-7yoilsho	2301	39	.	.	.
cord-006229-7yoilsho	2302	1	The	the	DT
cord-006229-7yoilsho	2302	2	analysis	analysis	NN
cord-006229-7yoilsho	2302	3	of	of	IN
cord-006229-7yoilsho	2302	4	Igfbp5	Igfbp5	NNP
cord-006229-7yoilsho	2302	5	expression	expression	NN
cord-006229-7yoilsho	2302	6	in	in	IN
cord-006229-7yoilsho	2302	7	different	different	JJ
cord-006229-7yoilsho	2302	8	heart	heart	NN
cord-006229-7yoilsho	2302	9	cells	cell	NNS
cord-006229-7yoilsho	2302	10	showed	show	VBD
cord-006229-7yoilsho	2302	11	a	a	DT
cord-006229-7yoilsho	2302	12	very	very	RB
cord-006229-7yoilsho	2302	13	low	low	JJ
cord-006229-7yoilsho	2302	14	Igfbp5	Igfbp5	NNP
cord-006229-7yoilsho	2302	15	in	in	IN
cord-006229-7yoilsho	2302	16	adult	adult	NN
cord-006229-7yoilsho	2302	17	cardiomyocytes	cardiomyocyte	NNS
cord-006229-7yoilsho	2302	18	in	in	IN
cord-006229-7yoilsho	2302	19	contrast	contrast	NN
cord-006229-7yoilsho	2302	20	to	to	IN
cord-006229-7yoilsho	2302	21	a	a	DT
cord-006229-7yoilsho	2302	22	high	high	JJ
cord-006229-7yoilsho	2302	23	expression	expression	NN
cord-006229-7yoilsho	2302	24	in	in	IN
cord-006229-7yoilsho	2302	25	undifferentiated	undifferentiated	JJ
cord-006229-7yoilsho	2302	26	Sca-1	Sca-1	NNP
cord-006229-7yoilsho	2302	27	positive	positive	JJ
cord-006229-7yoilsho	2302	28	cells	cell	NNS
cord-006229-7yoilsho	2302	29	.	.	.
cord-006229-7yoilsho	2303	1	In	in	IN
cord-006229-7yoilsho	2303	2	a	a	DT
cord-006229-7yoilsho	2303	3	mouse	mouse	NN
cord-006229-7yoilsho	2303	4	model	model	NN
cord-006229-7yoilsho	2303	5	with	with	IN
cord-006229-7yoilsho	2303	6	cardiac	cardiac	JJ
cord-006229-7yoilsho	2303	7	specific	specific	JJ
cord-006229-7yoilsho	2303	8	Wnt	Wnt	NNP
cord-006229-7yoilsho	2303	9	/	/	SYM
cord-006229-7yoilsho	2303	10	βcatenin	βcatenin	NNP
cord-006229-7yoilsho	2303	11	activation	activation	NN
cord-006229-7yoilsho	2303	12	,	,	,
cord-006229-7yoilsho	2303	13	which	which	WDT
cord-006229-7yoilsho	2303	14	led	lead	VBD
cord-006229-7yoilsho	2303	15	to	to	IN
cord-006229-7yoilsho	2303	16	cardiac	cardiac	JJ
cord-006229-7yoilsho	2303	17	dysfunction	dysfunction	NN
cord-006229-7yoilsho	2303	18	,	,	,
cord-006229-7yoilsho	2303	19	Igfbp5	Igfbp5	NNP
cord-006229-7yoilsho	2303	20	was	be	VBD
cord-006229-7yoilsho	2303	21	found	find	VBN
cord-006229-7yoilsho	2303	22	up	up	RB
cord-006229-7yoilsho	2303	23	-	-	HYPH
cord-006229-7yoilsho	2303	24	regulated	regulated	JJ
cord-006229-7yoilsho	2303	25	(	(	-LRB-
cord-006229-7yoilsho	2303	26	p<0.05	p<0.05	CD
cord-006229-7yoilsho	2303	27	)	)	-RRB-
cord-006229-7yoilsho	2303	28	.	.	.
cord-006229-7yoilsho	2304	1	Further	further	RB
cord-006229-7yoilsho	2304	2	we	-PRON-	PRP
cord-006229-7yoilsho	2304	3	found	find	VBD
cord-006229-7yoilsho	2304	4	an	an	DT
cord-006229-7yoilsho	2304	5	increased	increase	VBN
cord-006229-7yoilsho	2304	6	Igfbp5	Igfbp5	NNP
cord-006229-7yoilsho	2304	7	expression	expression	NN
cord-006229-7yoilsho	2304	8	after	after	IN
cord-006229-7yoilsho	2304	9	pressure	pressure	NN
cord-006229-7yoilsho	2304	10	induced	induce	VBN
cord-006229-7yoilsho	2304	11	cardiac	cardiac	JJ
cord-006229-7yoilsho	2304	12	hypertrophy	hypertrophy	NN
cord-006229-7yoilsho	2304	13	using	use	VBG
cord-006229-7yoilsho	2304	14	mice	mouse	NNS
cord-006229-7yoilsho	2304	15	with	with	IN
cord-006229-7yoilsho	2304	16	transverse	transverse	JJ
cord-006229-7yoilsho	2304	17	aortic	aortic	JJ
cord-006229-7yoilsho	2304	18	constriction	constriction	NN
cord-006229-7yoilsho	2304	19	(	(	-LRB-
cord-006229-7yoilsho	2304	20	TAC	TAC	NNP
cord-006229-7yoilsho	2304	21	)	)	-RRB-
cord-006229-7yoilsho	2304	22	(	(	-LRB-
cord-006229-7yoilsho	2304	23	p<0.01	p<0.01	NNP
cord-006229-7yoilsho	2304	24	)	)	-RRB-
cord-006229-7yoilsho	2304	25	.	.	.
cord-006229-7yoilsho	2305	1	In	in	IN
cord-006229-7yoilsho	2305	2	line	line	NN
cord-006229-7yoilsho	2305	3	with	with	IN
cord-006229-7yoilsho	2305	4	this	this	DT
cord-006229-7yoilsho	2305	5	data	data	NN
cord-006229-7yoilsho	2305	6	,	,	,
cord-006229-7yoilsho	2305	7	an	an	DT
cord-006229-7yoilsho	2305	8	in	in	FW
cord-006229-7yoilsho	2305	9	vitro	vitro	FW
cord-006229-7yoilsho	2305	10	model	model	NN
cord-006229-7yoilsho	2305	11	of	of	IN
cord-006229-7yoilsho	2305	12	human	human	JJ
cord-006229-7yoilsho	2305	13	heart	heart	NN
cord-006229-7yoilsho	2305	14	muscle	muscle	NN
cord-006229-7yoilsho	2305	15	hypertrophy	hypertrophy	NN
cord-006229-7yoilsho	2305	16	using	use	VBG
cord-006229-7yoilsho	2305	17	engineered	engineer	VBN
cord-006229-7yoilsho	2305	18	cardiac	cardiac	JJ
cord-006229-7yoilsho	2305	19	heart	heart	NN
cord-006229-7yoilsho	2305	20	muscle	muscle	NN
cord-006229-7yoilsho	2305	21	(	(	-LRB-
cord-006229-7yoilsho	2305	22	EHM	ehm	UH
cord-006229-7yoilsho	2305	23	)	)	-RRB-
cord-006229-7yoilsho	2305	24	showed	show	VBD
cord-006229-7yoilsho	2305	25	an	an	DT
cord-006229-7yoilsho	2305	26	up	up	JJ
cord-006229-7yoilsho	2305	27	-	-	HYPH
cord-006229-7yoilsho	2305	28	regulation	regulation	NN
cord-006229-7yoilsho	2305	29	of	of	IN
cord-006229-7yoilsho	2305	30	IGFBP5	IGFBP5	NNS
cord-006229-7yoilsho	2305	31	upon	upon	IN
cord-006229-7yoilsho	2305	32	adrenergic	adrenergic	JJ
cord-006229-7yoilsho	2305	33	activation	activation	NN
cord-006229-7yoilsho	2305	34	via	via	IN
cord-006229-7yoilsho	2305	35	norepinephrine	norepinephrine	NN
cord-006229-7yoilsho	2305	36	stimulation	stimulation	NN
cord-006229-7yoilsho	2305	37	accompanied	accompany	VBN
cord-006229-7yoilsho	2305	38	by	by	IN
cord-006229-7yoilsho	2305	39	a	a	DT
cord-006229-7yoilsho	2305	40	functional	functional	JJ
cord-006229-7yoilsho	2305	41	deterioration	deterioration	NN
cord-006229-7yoilsho	2305	42	in	in	IN
cord-006229-7yoilsho	2305	43	comparison	comparison	NN
cord-006229-7yoilsho	2305	44	to	to	IN
cord-006229-7yoilsho	2305	45	untreated	untreated	JJ
cord-006229-7yoilsho	2305	46	controls	control	NNS
cord-006229-7yoilsho	2305	47	(	(	-LRB-
cord-006229-7yoilsho	2305	48	p<0.05	p<0.05	CD
cord-006229-7yoilsho	2305	49	)	)	-RRB-
cord-006229-7yoilsho	2305	50	.	.	.
cord-006229-7yoilsho	2306	1	All	all	PDT
cord-006229-7yoilsho	2306	2	these	these	DT
cord-006229-7yoilsho	2306	3	findings	finding	NNS
cord-006229-7yoilsho	2306	4	were	be	VBD
cord-006229-7yoilsho	2306	5	further	further	RB
cord-006229-7yoilsho	2306	6	supported	support	VBN
cord-006229-7yoilsho	2306	7	by	by	IN
cord-006229-7yoilsho	2306	8	RNA	rna	NN
cord-006229-7yoilsho	2306	9	-	-	HYPH
cord-006229-7yoilsho	2306	10	sequencing	sequence	VBG
cord-006229-7yoilsho	2306	11	analysis	analysis	NN
cord-006229-7yoilsho	2306	12	from	from	IN
cord-006229-7yoilsho	2306	13	human	human	JJ
cord-006229-7yoilsho	2306	14	aortic	aortic	JJ
cord-006229-7yoilsho	2306	15	stenosis	stenosis	NN
cord-006229-7yoilsho	2306	16	patient	patient	NN
cord-006229-7yoilsho	2306	17	samples	sample	NNS
cord-006229-7yoilsho	2306	18	,	,	,
cord-006229-7yoilsho	2306	19	where	where	WRB
cord-006229-7yoilsho	2306	20	IGFBP5	igfbp5	JJ
cord-006229-7yoilsho	2306	21	expression	expression	NN
cord-006229-7yoilsho	2306	22	was	be	VBD
cord-006229-7yoilsho	2306	23	found	find	VBN
cord-006229-7yoilsho	2306	24	increased	increase	VBN
cord-006229-7yoilsho	2306	25	in	in	IN
cord-006229-7yoilsho	2306	26	patients	patient	NNS
cord-006229-7yoilsho	2306	27	with	with	IN
cord-006229-7yoilsho	2306	28	compensatory	compensatory	JJ
cord-006229-7yoilsho	2306	29	hypertrophy	hypertrophy	NN
cord-006229-7yoilsho	2306	30	and	and	CC
cord-006229-7yoilsho	2306	31	in	in	IN
cord-006229-7yoilsho	2306	32	a	a	DT
cord-006229-7yoilsho	2306	33	higher	high	JJR
cord-006229-7yoilsho	2306	34	extent	extent	NN
cord-006229-7yoilsho	2306	35	in	in	IN
cord-006229-7yoilsho	2306	36	patients	patient	NNS
cord-006229-7yoilsho	2306	37	with	with	IN
cord-006229-7yoilsho	2306	38	heart	heart	NN
cord-006229-7yoilsho	2306	39	failure	failure	NN
cord-006229-7yoilsho	2306	40	in	in	IN
cord-006229-7yoilsho	2306	41	comparison	comparison	NN
cord-006229-7yoilsho	2306	42	to	to	IN
cord-006229-7yoilsho	2306	43	non	non	JJ
cord-006229-7yoilsho	2306	44	-	-	JJ
cord-006229-7yoilsho	2306	45	failing	failing	JJ
cord-006229-7yoilsho	2306	46	heart	heart	NN
cord-006229-7yoilsho	2306	47	samples	sample	NNS
cord-006229-7yoilsho	2306	48	.	.	.
cord-006229-7yoilsho	2307	1	Interestingly	interestingly	RB
cord-006229-7yoilsho	2307	2	,	,	,
cord-006229-7yoilsho	2307	3	the	the	DT
cord-006229-7yoilsho	2307	4	expression	expression	NN
cord-006229-7yoilsho	2307	5	of	of	IN
cord-006229-7yoilsho	2307	6	Igfbp5	Igfbp5	NNP
cord-006229-7yoilsho	2307	7	in	in	IN
cord-006229-7yoilsho	2307	8	angiotensin	angiotensin	NN
cord-006229-7yoilsho	2307	9	2	2	CD
cord-006229-7yoilsho	2307	10	or	or	CC
cord-006229-7yoilsho	2307	11	norepinephrine	norepinephrine	NN
cord-006229-7yoilsho	2307	12	stimulated	stimulate	VBD
cord-006229-7yoilsho	2307	13	neonatal	neonatal	JJ
cord-006229-7yoilsho	2307	14	murine	murine	JJ
cord-006229-7yoilsho	2307	15	cardiomyocytes	cardiomyocyte	NNS
cord-006229-7yoilsho	2307	16	,	,	,
cord-006229-7yoilsho	2307	17	as	as	RB
cord-006229-7yoilsho	2307	18	well	well	RB
cord-006229-7yoilsho	2307	19	as	as	IN
cord-006229-7yoilsho	2307	20	in	in	IN
cord-006229-7yoilsho	2307	21	hearts	heart	NNS
cord-006229-7yoilsho	2307	22	of	of	IN
cord-006229-7yoilsho	2307	23	mice	mouse	NNS
cord-006229-7yoilsho	2307	24	treated	treat	VBN
cord-006229-7yoilsho	2307	25	with	with	IN
cord-006229-7yoilsho	2307	26	angiotensin	angiotensin	NN
cord-006229-7yoilsho	2307	27	2	2	CD
cord-006229-7yoilsho	2307	28	,	,	,
cord-006229-7yoilsho	2307	29	showed	show	VBD
cord-006229-7yoilsho	2307	30	the	the	DT
cord-006229-7yoilsho	2307	31	opposite	opposite	JJ
cord-006229-7yoilsho	2307	32	results	result	NNS
cord-006229-7yoilsho	2307	33	,	,	,
cord-006229-7yoilsho	2307	34	namely	namely	RB
cord-006229-7yoilsho	2307	35	a	a	DT
cord-006229-7yoilsho	2307	36	reduction	reduction	NN
cord-006229-7yoilsho	2307	37	in	in	IN
cord-006229-7yoilsho	2307	38	its	-PRON-	PRP$
cord-006229-7yoilsho	2307	39	expression	expression	NN
cord-006229-7yoilsho	2307	40	(	(	-LRB-
cord-006229-7yoilsho	2307	41	p<0.01	p<0.01	NNP
cord-006229-7yoilsho	2307	42	;	;	:
cord-006229-7yoilsho	2307	43	p<0.05	p<0.05	CD
cord-006229-7yoilsho	2307	44	,	,	,
cord-006229-7yoilsho	2307	45	respectively	respectively	RB
cord-006229-7yoilsho	2307	46	)	)	-RRB-
cord-006229-7yoilsho	2307	47	.	.	.
cord-006229-7yoilsho	2308	1	Summary	Summary	NNP
cord-006229-7yoilsho	2308	2	and	and	CC
cord-006229-7yoilsho	2308	3	Conclusion	conclusion	NN
cord-006229-7yoilsho	2308	4	:	:	:
cord-006229-7yoilsho	2308	5	Our	-PRON-	PRP$
cord-006229-7yoilsho	2308	6	results	result	NNS
cord-006229-7yoilsho	2308	7	show	show	VBP
cord-006229-7yoilsho	2308	8	active	active	JJ
cord-006229-7yoilsho	2308	9	Igfbp5	Igfbp5	NNP
cord-006229-7yoilsho	2308	10	transcription	transcription	NN
cord-006229-7yoilsho	2308	11	in	in	IN
cord-006229-7yoilsho	2308	12	the	the	DT
cord-006229-7yoilsho	2308	13	early	early	JJ
cord-006229-7yoilsho	2308	14	developing	develop	VBG
cord-006229-7yoilsho	2308	15	heart	heart	NN
cord-006229-7yoilsho	2308	16	but	but	CC
cord-006229-7yoilsho	2308	17	a	a	DT
cord-006229-7yoilsho	2308	18	low	low	JJ
cord-006229-7yoilsho	2308	19	expression	expression	NN
cord-006229-7yoilsho	2308	20	in	in	IN
cord-006229-7yoilsho	2308	21	the	the	DT
cord-006229-7yoilsho	2308	22	postnatal	postnatal	JJ
cord-006229-7yoilsho	2308	23	heart	heart	NN
cord-006229-7yoilsho	2308	24	.	.	.
cord-006229-7yoilsho	2309	1	A	a	DT
cord-006229-7yoilsho	2309	2	re	re	NN
cord-006229-7yoilsho	2309	3	-	-	NN
cord-006229-7yoilsho	2309	4	activation	activation	NN
cord-006229-7yoilsho	2309	5	of	of	IN
cord-006229-7yoilsho	2309	6	expression	expression	NN
cord-006229-7yoilsho	2309	7	was	be	VBD
cord-006229-7yoilsho	2309	8	found	find	VBN
cord-006229-7yoilsho	2309	9	in	in	IN
cord-006229-7yoilsho	2309	10	the	the	DT
cord-006229-7yoilsho	2309	11	process	process	NN
cord-006229-7yoilsho	2309	12	of	of	IN
cord-006229-7yoilsho	2309	13	pathological	pathological	JJ
cord-006229-7yoilsho	2309	14	heart	heart	NN
cord-006229-7yoilsho	2309	15	remodeling	remodeling	NN
cord-006229-7yoilsho	2309	16	in	in	IN
cord-006229-7yoilsho	2309	17	mouse	mouse	NN
cord-006229-7yoilsho	2309	18	and	and	CC
cord-006229-7yoilsho	2309	19	human	human	NN
cord-006229-7yoilsho	2309	20	,	,	,
cord-006229-7yoilsho	2309	21	in	in	IN
cord-006229-7yoilsho	2309	22	vivo	vivo	NN
cord-006229-7yoilsho	2309	23	as	as	RB
cord-006229-7yoilsho	2309	24	well	well	RB
cord-006229-7yoilsho	2309	25	as	as	IN
cord-006229-7yoilsho	2309	26	in	in	IN
cord-006229-7yoilsho	2309	27	vitro	vitro	FW
cord-006229-7yoilsho	2309	28	,	,	,
cord-006229-7yoilsho	2309	29	indicate	indicate	VBP
cord-006229-7yoilsho	2309	30	the	the	DT
cord-006229-7yoilsho	2309	31	participation	participation	NN
cord-006229-7yoilsho	2309	32	of	of	IN
cord-006229-7yoilsho	2309	33	IGFBP5	IGFBP5	NNS
cord-006229-7yoilsho	2309	34	in	in	IN
cord-006229-7yoilsho	2309	35	a	a	DT
cord-006229-7yoilsho	2309	36	conserved	conserved	JJ
cord-006229-7yoilsho	2309	37	manner	manner	NN
cord-006229-7yoilsho	2309	38	.	.	.
cord-006229-7yoilsho	2310	1	We	-PRON-	PRP
cord-006229-7yoilsho	2310	2	hypothesize	hypothesize	VBP
cord-006229-7yoilsho	2310	3	that	that	IN
cord-006229-7yoilsho	2310	4	IGFBP5	IGFBP5	NNS
cord-006229-7yoilsho	2310	5	may	may	MD
cord-006229-7yoilsho	2310	6	participate	participate	VB
cord-006229-7yoilsho	2310	7	in	in	IN
cord-006229-7yoilsho	2310	8	the	the	DT
cord-006229-7yoilsho	2310	9	developmental	developmental	JJ
cord-006229-7yoilsho	2310	10	gene	gene	NN
cord-006229-7yoilsho	2310	11	program	program	NN
cord-006229-7yoilsho	2310	12	becoming	become	VBG
cord-006229-7yoilsho	2310	13	activated	activate	VBN
cord-006229-7yoilsho	2310	14	in	in	IN
cord-006229-7yoilsho	2310	15	the	the	DT
cord-006229-7yoilsho	2310	16	diseased	diseased	JJ
cord-006229-7yoilsho	2310	17	adult	adult	NN
cord-006229-7yoilsho	2310	18	heart	heart	NN
cord-006229-7yoilsho	2310	19	again	again	RB
cord-006229-7yoilsho	2310	20	.	.	.
cord-006229-7yoilsho	2311	1	The	the	DT
cord-006229-7yoilsho	2311	2	functional	functional	JJ
cord-006229-7yoilsho	2311	3	role	role	NN
cord-006229-7yoilsho	2311	4	and	and	CC
cord-006229-7yoilsho	2311	5	regulation	regulation	NN
cord-006229-7yoilsho	2311	6	of	of	IN
cord-006229-7yoilsho	2311	7	IGFBP5	IGFBP5	NNP
cord-006229-7yoilsho	2311	8	is	be	VBZ
cord-006229-7yoilsho	2311	9	under	under	IN
cord-006229-7yoilsho	2311	10	investigation	investigation	NN
cord-006229-7yoilsho	2311	11	.	.	.
cord-006229-7yoilsho	2312	1	We	-PRON-	PRP
cord-006229-7yoilsho	2312	2	have	have	VBP
cord-006229-7yoilsho	2312	3	recently	recently	RB
cord-006229-7yoilsho	2312	4	shown	show	VBN
cord-006229-7yoilsho	2312	5	that	that	IN
cord-006229-7yoilsho	2312	6	perivascular	perivascular	JJ
cord-006229-7yoilsho	2312	7	adipose	adipose	JJ
cord-006229-7yoilsho	2312	8	tissue	tissue	NN
cord-006229-7yoilsho	2312	9	(	(	-LRB-
cord-006229-7yoilsho	2312	10	PVAT	PVAT	NNP
cord-006229-7yoilsho	2312	11	)	)	-RRB-
cord-006229-7yoilsho	2312	12	plays	play	VBZ
cord-006229-7yoilsho	2312	13	a	a	DT
cord-006229-7yoilsho	2312	14	crucial	crucial	JJ
cord-006229-7yoilsho	2312	15	role	role	NN
cord-006229-7yoilsho	2312	16	in	in	IN
cord-006229-7yoilsho	2312	17	obesity	obesity	NN
cord-006229-7yoilsho	2312	18	-	-	HYPH
cord-006229-7yoilsho	2312	19	induced	induce	VBN
cord-006229-7yoilsho	2312	20	vascular	vascular	JJ
cord-006229-7yoilsho	2312	21	dysfunction	dysfunction	NN
cord-006229-7yoilsho	2312	22	.	.	.
cord-006229-7yoilsho	2313	1	In	in	IN
cord-006229-7yoilsho	2313	2	PVAT	PVAT	NNP
cord-006229-7yoilsho	2313	3	-	-	HYPH
cord-006229-7yoilsho	2313	4	free	free	JJ
cord-006229-7yoilsho	2313	5	aortas	aorta	NNS
cord-006229-7yoilsho	2313	6	isolated	isolate	VBN
cord-006229-7yoilsho	2313	7	from	from	IN
cord-006229-7yoilsho	2313	8	male	male	JJ
cord-006229-7yoilsho	2313	9	C57BL/6J	C57BL/6J	NNP
cord-006229-7yoilsho	2313	10	mice	mouse	NNS
cord-006229-7yoilsho	2313	11	fed	feed	VBD
cord-006229-7yoilsho	2313	12	a	a	DT
cord-006229-7yoilsho	2313	13	high	high	JJ
cord-006229-7yoilsho	2313	14	-	-	HYPH
cord-006229-7yoilsho	2313	15	fat	fat	NN
cord-006229-7yoilsho	2313	16	diet	diet	NN
cord-006229-7yoilsho	2313	17	(	(	-LRB-
cord-006229-7yoilsho	2313	18	HFD	HFD	NNP
cord-006229-7yoilsho	2313	19	)	)	-RRB-
cord-006229-7yoilsho	2313	20	for	for	IN
cord-006229-7yoilsho	2313	21	22	22	CD
cord-006229-7yoilsho	2313	22	weeks	week	NNS
cord-006229-7yoilsho	2313	23	,	,	,
cord-006229-7yoilsho	2313	24	the	the	DT
cord-006229-7yoilsho	2313	25	endothelium	endothelium	NN
cord-006229-7yoilsho	2313	26	-	-	HYPH
cord-006229-7yoilsho	2313	27	dependent	dependent	JJ
cord-006229-7yoilsho	2313	28	nitric	nitric	NN
cord-006229-7yoilsho	2313	29	oxide	oxide	NN
cord-006229-7yoilsho	2313	30	(	(	-LRB-
cord-006229-7yoilsho	2313	31	NO)-mediated	no)-mediated	CD
cord-006229-7yoilsho	2313	32	vasodilator	vasodilator	NN
cord-006229-7yoilsho	2313	33	response	response	NN
cord-006229-7yoilsho	2313	34	to	to	IN
cord-006229-7yoilsho	2313	35	acetylcholine	acetylcholine	NN
cord-006229-7yoilsho	2313	36	remained	remain	VBD
cord-006229-7yoilsho	2313	37	normal	normal	JJ
cord-006229-7yoilsho	2313	38	.	.	.
cord-006229-7yoilsho	2314	1	In	in	IN
cord-006229-7yoilsho	2314	2	contrast	contrast	NN
cord-006229-7yoilsho	2314	3	,	,	,
cord-006229-7yoilsho	2314	4	a	a	DT
cord-006229-7yoilsho	2314	5	clear	clear	JJ
cord-006229-7yoilsho	2314	6	reduction	reduction	NN
cord-006229-7yoilsho	2314	7	in	in	IN
cord-006229-7yoilsho	2314	8	the	the	DT
cord-006229-7yoilsho	2314	9	vasodilator	vasodilator	NN
cord-006229-7yoilsho	2314	10	response	response	NN
cord-006229-7yoilsho	2314	11	to	to	IN
cord-006229-7yoilsho	2314	12	acetylcholine	acetylcholine	NN
cord-006229-7yoilsho	2314	13	was	be	VBD
cord-006229-7yoilsho	2314	14	observed	observe	VBN
cord-006229-7yoilsho	2314	15	in	in	IN
cord-006229-7yoilsho	2314	16	aortas	aorta	NNS
cord-006229-7yoilsho	2314	17	from	from	IN
cord-006229-7yoilsho	2314	18	obese	obese	JJ
cord-006229-7yoilsho	2314	19	mice	mouse	NNS
cord-006229-7yoilsho	2314	20	when	when	WRB
cord-006229-7yoilsho	2314	21	PVAT	PVAT	NNP
cord-006229-7yoilsho	2314	22	was	be	VBD
cord-006229-7yoilsho	2314	23	left	leave	VBN
cord-006229-7yoilsho	2314	24	in	in	IN
cord-006229-7yoilsho	2314	25	place	place	NN
cord-006229-7yoilsho	2314	26	.	.	.
cord-006229-7yoilsho	2315	1	These	these	DT
cord-006229-7yoilsho	2315	2	results	result	NNS
cord-006229-7yoilsho	2315	3	suggest	suggest	VBP
cord-006229-7yoilsho	2315	4	that	that	IN
cord-006229-7yoilsho	2315	5	the	the	DT
cord-006229-7yoilsho	2315	6	reason	reason	NN
cord-006229-7yoilsho	2315	7	for	for	IN
cord-006229-7yoilsho	2315	8	vascular	vascular	JJ
cord-006229-7yoilsho	2315	9	dysfunction	dysfunction	NN
cord-006229-7yoilsho	2315	10	in	in	IN
cord-006229-7yoilsho	2315	11	diet	diet	NN
cord-006229-7yoilsho	2315	12	-	-	HYPH
cord-006229-7yoilsho	2315	13	induced	induce	VBN
cord-006229-7yoilsho	2315	14	obese	obese	JJ
cord-006229-7yoilsho	2315	15	mice	mice	NN
cord-006229-7yoilsho	2315	16	is	be	VBZ
cord-006229-7yoilsho	2315	17	a	a	DT
cord-006229-7yoilsho	2315	18	PVAT	PVAT	NNP
cord-006229-7yoilsho	2315	19	dysfunction	dysfunction	NN
cord-006229-7yoilsho	2315	20	rather	rather	RB
cord-006229-7yoilsho	2315	21	than	than	IN
cord-006229-7yoilsho	2315	22	an	an	DT
cord-006229-7yoilsho	2315	23	endothelial	endothelial	JJ
cord-006229-7yoilsho	2315	24	dysfunction	dysfunction	NN
cord-006229-7yoilsho	2315	25	.	.	.
cord-006229-7yoilsho	2316	1	Treatment	treatment	NN
cord-006229-7yoilsho	2316	2	of	of	IN
cord-006229-7yoilsho	2316	3	HFD	HFD	NNP
cord-006229-7yoilsho	2316	4	mice	mouse	NNS
cord-006229-7yoilsho	2316	5	during	during	IN
cord-006229-7yoilsho	2316	6	the	the	DT
cord-006229-7yoilsho	2316	7	last	last	JJ
cord-006229-7yoilsho	2316	8	4	4	CD
cord-006229-7yoilsho	2316	9	weeks	week	NNS
cord-006229-7yoilsho	2316	10	with	with	IN
cord-006229-7yoilsho	2316	11	Crataegus	Crataegus	NNP
cord-006229-7yoilsho	2316	12	extract	extract	NN
cord-006229-7yoilsho	2316	13	WS	WS	NNP
cord-006229-7yoilsho	2317	1	®	®	LS
cord-006229-7yoilsho	2317	2	1442	1442	CD
cord-006229-7yoilsho	2317	3	(	(	-LRB-
cord-006229-7yoilsho	2317	4	150	150	CD
cord-006229-7yoilsho	2317	5	mg	mg	NNP
cord-006229-7yoilsho	2317	6	/	/	SYM
cord-006229-7yoilsho	2317	7	kg	kg	NNP
cord-006229-7yoilsho	2317	8	/	/	SYM
cord-006229-7yoilsho	2317	9	day	day	NN
cord-006229-7yoilsho	2317	10	)	)	-RRB-
cord-006229-7yoilsho	2317	11	completely	completely	RB
cord-006229-7yoilsho	2317	12	normalized	normalize	VBN
cord-006229-7yoilsho	2317	13	vascular	vascular	JJ
cord-006229-7yoilsho	2317	14	function	function	NN
cord-006229-7yoilsho	2317	15	in	in	IN
cord-006229-7yoilsho	2317	16	PVATcontaining	pvatcontaine	VBG
cord-006229-7yoilsho	2317	17	aorta	aorta	NN
cord-006229-7yoilsho	2317	18	.	.	.
cord-006229-7yoilsho	2318	1	The	the	DT
cord-006229-7yoilsho	2318	2	expression	expression	NN
cord-006229-7yoilsho	2318	3	of	of	IN
cord-006229-7yoilsho	2318	4	endothelial	endothelial	JJ
cord-006229-7yoilsho	2318	5	NO	no	DT
cord-006229-7yoilsho	2318	6	synthase	synthase	NN
cord-006229-7yoilsho	2318	7	(	(	-LRB-
cord-006229-7yoilsho	2318	8	eNOS	eNOS	NNP
cord-006229-7yoilsho	2318	9	)	)	-RRB-
cord-006229-7yoilsho	2318	10	was	be	VBD
cord-006229-7yoilsho	2318	11	not	not	RB
cord-006229-7yoilsho	2318	12	changed	change	VBN
cord-006229-7yoilsho	2318	13	by	by	IN
cord-006229-7yoilsho	2318	14	WS	WS	NNP
cord-006229-7yoilsho	2319	1	®	®	LS
cord-006229-7yoilsho	2319	2	1442	1442	CD
cord-006229-7yoilsho	2319	3	,	,	,
cord-006229-7yoilsho	2319	4	neither	neither	CC
cord-006229-7yoilsho	2319	5	in	in	IN
cord-006229-7yoilsho	2319	6	PVAT	PVAT	NNP
cord-006229-7yoilsho	2319	7	nor	nor	CC
cord-006229-7yoilsho	2319	8	in	in	IN
cord-006229-7yoilsho	2319	9	aorta	aorta	NN
cord-006229-7yoilsho	2319	10	.	.	.
cord-006229-7yoilsho	2320	1	Phosphorylation	Phosphorylation	NNP
cord-006229-7yoilsho	2320	2	at	at	IN
cord-006229-7yoilsho	2320	3	Serine	Serine	NNP
cord-006229-7yoilsho	2320	4	1177	1177	CD
cord-006229-7yoilsho	2320	5	is	be	VBZ
cord-006229-7yoilsho	2320	6	the	the	DT
cord-006229-7yoilsho	2320	7	most	most	RBS
cord-006229-7yoilsho	2320	8	important	important	JJ
cord-006229-7yoilsho	2320	9	positive	positive	JJ
cord-006229-7yoilsho	2320	10	modulation	modulation	NN
cord-006229-7yoilsho	2320	11	of	of	IN
cord-006229-7yoilsho	2320	12	eNOS	enos	JJ
cord-006229-7yoilsho	2320	13	activity	activity	NN
cord-006229-7yoilsho	2320	14	.	.	.
cord-006229-7yoilsho	2321	1	HFD	HFD	NNP
cord-006229-7yoilsho	2321	2	-	-	HYPH
cord-006229-7yoilsho	2321	3	induced	induce	VBN
cord-006229-7yoilsho	2321	4	obesity	obesity	NN
cord-006229-7yoilsho	2321	5	was	be	VBD
cord-006229-7yoilsho	2321	6	associated	associate	VBN
cord-006229-7yoilsho	2321	7	with	with	IN
cord-006229-7yoilsho	2321	8	a	a	DT
cord-006229-7yoilsho	2321	9	reduction	reduction	NN
cord-006229-7yoilsho	2321	10	in	in	IN
cord-006229-7yoilsho	2321	11	eNOS	enos	JJ
cord-006229-7yoilsho	2321	12	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	2321	13	at	at	IN
cord-006229-7yoilsho	2321	14	serine	serine	NN
cord-006229-7yoilsho	2321	15	1177	1177	CD
cord-006229-7yoilsho	2321	16	in	in	IN
cord-006229-7yoilsho	2321	17	PVAT	PVAT	NNP
cord-006229-7yoilsho	2321	18	,	,	,
cord-006229-7yoilsho	2321	19	but	but	CC
cord-006229-7yoilsho	2321	20	not	not	RB
cord-006229-7yoilsho	2321	21	in	in	IN
cord-006229-7yoilsho	2321	22	aorta	aorta	NN
cord-006229-7yoilsho	2321	23	.	.	.
cord-006229-7yoilsho	2322	1	WS	WS	NNP
cord-006229-7yoilsho	2323	1	®	®	LS
cord-006229-7yoilsho	2323	2	1442	1442	CD
cord-006229-7yoilsho	2323	3	treatment	treatment	NN
cord-006229-7yoilsho	2323	4	significantly	significantly	RB
cord-006229-7yoilsho	2323	5	improved	improve	VBD
cord-006229-7yoilsho	2323	6	eNOS	enos	JJ
cord-006229-7yoilsho	2323	7	serine	serine	NN
cord-006229-7yoilsho	2323	8	1177	1177	CD
cord-006229-7yoilsho	2323	9	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	2323	10	selectively	selectively	RB
cord-006229-7yoilsho	2323	11	in	in	IN
cord-006229-7yoilsho	2323	12	PVAT	PVAT	NNS
cord-006229-7yoilsho	2323	13	but	but	CC
cord-006229-7yoilsho	2323	14	had	have	VBD
cord-006229-7yoilsho	2323	15	no	no	DT
cord-006229-7yoilsho	2323	16	effect	effect	NN
cord-006229-7yoilsho	2323	17	in	in	IN
cord-006229-7yoilsho	2323	18	aorta	aorta	NN
cord-006229-7yoilsho	2323	19	.	.	.
cord-006229-7yoilsho	2324	1	A	a	DT
cord-006229-7yoilsho	2324	2	major	major	JJ
cord-006229-7yoilsho	2324	3	upstream	upstream	JJ
cord-006229-7yoilsho	2324	4	kinase	kinase	NN
cord-006229-7yoilsho	2324	5	for	for	IN
cord-006229-7yoilsho	2324	6	eNOS	enos	JJ
cord-006229-7yoilsho	2324	7	serine	serine	NN
cord-006229-7yoilsho	2324	8	1177	1177	CD
cord-006229-7yoilsho	2324	9	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	2324	10	is	be	VBZ
cord-006229-7yoilsho	2324	11	Akt	Akt	NNP
cord-006229-7yoilsho	2324	12	.	.	.
cord-006229-7yoilsho	2325	1	The	the	DT
cord-006229-7yoilsho	2325	2	activity	activity	NN
cord-006229-7yoilsho	2325	3	of	of	IN
cord-006229-7yoilsho	2325	4	this	this	DT
cord-006229-7yoilsho	2325	5	kinase	kinase	NN
cord-006229-7yoilsho	2325	6	is	be	VBZ
cord-006229-7yoilsho	2325	7	inhibited	inhibit	VBN
cord-006229-7yoilsho	2325	8	in	in	IN
cord-006229-7yoilsho	2325	9	the	the	DT
cord-006229-7yoilsho	2325	10	PVAT	PVAT	NNS
cord-006229-7yoilsho	2325	11	of	of	IN
cord-006229-7yoilsho	2325	12	HFD	HFD	NNP
cord-006229-7yoilsho	2325	13	mice	mouse	NNS
cord-006229-7yoilsho	2325	14	,	,	,
cord-006229-7yoilsho	2325	15	which	which	WDT
cord-006229-7yoilsho	2325	16	was	be	VBD
cord-006229-7yoilsho	2325	17	largely	largely	RB
cord-006229-7yoilsho	2325	18	reversed	reverse	VBN
cord-006229-7yoilsho	2325	19	by	by	IN
cord-006229-7yoilsho	2325	20	WS	WS	NNP
cord-006229-7yoilsho	2325	21	®	®	POS
cord-006229-7yoilsho	2325	22	1442	1442	CD
cord-006229-7yoilsho	2325	23	treatment	treatment	NN
cord-006229-7yoilsho	2325	24	.	.	.
cord-006229-7yoilsho	2326	1	In	in	IN
cord-006229-7yoilsho	2326	2	addition	addition	NN
cord-006229-7yoilsho	2326	3	,	,	,
cord-006229-7yoilsho	2326	4	WS	WS	NNP
cord-006229-7yoilsho	2326	5	®	®	POS
cord-006229-7yoilsho	2326	6	1442	1442	CD
cord-006229-7yoilsho	2326	7	treatment	treatment	NN
cord-006229-7yoilsho	2326	8	enhanced	enhance	VBD
cord-006229-7yoilsho	2326	9	the	the	DT
cord-006229-7yoilsho	2326	10	mRNA	mRNA	NNP
cord-006229-7yoilsho	2326	11	expression	expression	NN
cord-006229-7yoilsho	2326	12	of	of	IN
cord-006229-7yoilsho	2326	13	the	the	DT
cord-006229-7yoilsho	2326	14	NAD	NAD	NNP
cord-006229-7yoilsho	2326	15	-	-	HYPH
cord-006229-7yoilsho	2326	16	dependent	dependent	JJ
cord-006229-7yoilsho	2326	17	deacetylase	deacetylase	NN
cord-006229-7yoilsho	2326	18	sirtuin-1	sirtuin-1	NNP
cord-006229-7yoilsho	2326	19	(	(	-LRB-
cord-006229-7yoilsho	2326	20	SIRT1	SIRT1	NNP
cord-006229-7yoilsho	2326	21	)	)	-RRB-
cord-006229-7yoilsho	2326	22	,	,	,
cord-006229-7yoilsho	2326	23	known	know	VBN
cord-006229-7yoilsho	2326	24	also	also	RB
cord-006229-7yoilsho	2326	25	as	as	IN
cord-006229-7yoilsho	2326	26	a	a	DT
cord-006229-7yoilsho	2326	27	longevity	longevity	NN
cord-006229-7yoilsho	2326	28	gene	gene	NN
cord-006229-7yoilsho	2326	29	.	.	.
cord-006229-7yoilsho	2327	1	The	the	DT
cord-006229-7yoilsho	2327	2	activity	activity	NN
cord-006229-7yoilsho	2327	3	of	of	IN
cord-006229-7yoilsho	2327	4	SIRT1	sirt1	NN
cord-006229-7yoilsho	2327	5	depends	depend	VBZ
cord-006229-7yoilsho	2327	6	,	,	,
cord-006229-7yoilsho	2327	7	among	among	IN
cord-006229-7yoilsho	2327	8	others	other	NNS
cord-006229-7yoilsho	2327	9	,	,	,
cord-006229-7yoilsho	2327	10	on	on	IN
cord-006229-7yoilsho	2327	11	the	the	DT
cord-006229-7yoilsho	2327	12	intracellular	intracellular	JJ
cord-006229-7yoilsho	2327	13	content	content	NN
cord-006229-7yoilsho	2327	14	of	of	IN
cord-006229-7yoilsho	2327	15	its	-PRON-	PRP$
cord-006229-7yoilsho	2327	16	cofactor	cofactor	NN
cord-006229-7yoilsho	2327	17	NAD	NAD	NNP
cord-006229-7yoilsho	2327	18	.	.	.
cord-006229-7yoilsho	2328	1	WS	WS	NNP
cord-006229-7yoilsho	2329	1	®	®	LS
cord-006229-7yoilsho	2329	2	1442	1442	CD
cord-006229-7yoilsho	2329	3	treatment	treatment	NN
cord-006229-7yoilsho	2329	4	led	lead	VBD
cord-006229-7yoilsho	2329	5	to	to	IN
cord-006229-7yoilsho	2329	6	an	an	DT
cord-006229-7yoilsho	2329	7	upregulation	upregulation	NN
cord-006229-7yoilsho	2329	8	of	of	IN
cord-006229-7yoilsho	2329	9	nicotinamide	nicotinamide	NN
cord-006229-7yoilsho	2329	10	phosphoribosyltransferase	phosphoribosyltransferase	NN
cord-006229-7yoilsho	2329	11	(	(	-LRB-
cord-006229-7yoilsho	2329	12	Nampt	Nampt	NNP
cord-006229-7yoilsho	2329	13	)	)	-RRB-
cord-006229-7yoilsho	2329	14	,	,	,
cord-006229-7yoilsho	2329	15	a	a	DT
cord-006229-7yoilsho	2329	16	rate	rate	NN
cord-006229-7yoilsho	2329	17	-	-	HYPH
cord-006229-7yoilsho	2329	18	limiting	limit	VBG
cord-006229-7yoilsho	2329	19	enzyme	enzyme	NN
cord-006229-7yoilsho	2329	20	in	in	IN
cord-006229-7yoilsho	2329	21	the	the	DT
cord-006229-7yoilsho	2329	22	salvage	salvage	NN
cord-006229-7yoilsho	2329	23	pathway	pathway	NN
cord-006229-7yoilsho	2329	24	of	of	IN
cord-006229-7yoilsho	2329	25	NAD	NAD	NNP
cord-006229-7yoilsho	2329	26	biosynthesis	biosynthesis	NN
cord-006229-7yoilsho	2329	27	.	.	.
cord-006229-7yoilsho	2330	1	One	one	CD
cord-006229-7yoilsho	2330	2	of	of	IN
cord-006229-7yoilsho	2330	3	the	the	DT
cord-006229-7yoilsho	2330	4	non	non	JJ
cord-006229-7yoilsho	2330	5	-	-	JJ
cord-006229-7yoilsho	2330	6	histone	histone	JJ
cord-006229-7yoilsho	2330	7	substrates	substrate	NNS
cord-006229-7yoilsho	2330	8	of	of	IN
cord-006229-7yoilsho	2330	9	SIRT1	SIRT1	NNP
cord-006229-7yoilsho	2330	10	is	be	VBZ
cord-006229-7yoilsho	2330	11	eNOS	enos	JJ
cord-006229-7yoilsho	2330	12	.	.	.
cord-006229-7yoilsho	2331	1	Deacetylation	Deacetylation	NNP
cord-006229-7yoilsho	2331	2	of	of	IN
cord-006229-7yoilsho	2331	3	eNOS	enos	JJ
cord-006229-7yoilsho	2331	4	at	at	IN
cord-006229-7yoilsho	2331	5	lysine	lysine	NN
cord-006229-7yoilsho	2331	6	residues	residue	NNS
cord-006229-7yoilsho	2331	7	497	497	CD
cord-006229-7yoilsho	2331	8	and	and	CC
cord-006229-7yoilsho	2331	9	507	507	CD
cord-006229-7yoilsho	2331	10	by	by	IN
cord-006229-7yoilsho	2331	11	SIRT1	SIRT1	NNP
cord-006229-7yoilsho	2331	12	enhances	enhance	VBZ
cord-006229-7yoilsho	2331	13	the	the	DT
cord-006229-7yoilsho	2331	14	activity	activity	NN
cord-006229-7yoilsho	2331	15	of	of	IN
cord-006229-7yoilsho	2331	16	the	the	DT
cord-006229-7yoilsho	2331	17	eNOS	enos	JJ
cord-006229-7yoilsho	2331	18	enzyme	enzyme	NN
cord-006229-7yoilsho	2331	19	.	.	.
cord-006229-7yoilsho	2332	1	Currently	currently	RB
cord-006229-7yoilsho	2332	2	,	,	,
cord-006229-7yoilsho	2332	3	we	-PRON-	PRP
cord-006229-7yoilsho	2332	4	are	be	VBP
cord-006229-7yoilsho	2332	5	studying	study	VBG
cord-006229-7yoilsho	2332	6	the	the	DT
cord-006229-7yoilsho	2332	7	effect	effect	NN
cord-006229-7yoilsho	2332	8	of	of	IN
cord-006229-7yoilsho	2332	9	WS	WS	NNP
cord-006229-7yoilsho	2333	1	®	®	LS
cord-006229-7yoilsho	2333	2	1442	1442	CD
cord-006229-7yoilsho	2333	3	on	on	IN
cord-006229-7yoilsho	2333	4	NAD	NAD	NNP
cord-006229-7yoilsho	2333	5	synthesis	synthesis	NN
cord-006229-7yoilsho	2333	6	,	,	,
cord-006229-7yoilsho	2333	7	SIRT1	sirt1	NN
cord-006229-7yoilsho	2333	8	activity	activity	NN
cord-006229-7yoilsho	2333	9	,	,	,
cord-006229-7yoilsho	2333	10	and	and	CC
cord-006229-7yoilsho	2334	1	eNOS	eNOS	NNP
cord-006229-7yoilsho	2334	2	(	(	-LRB-
cord-006229-7yoilsho	2334	3	de)acetylation	de)acetylation	NNP
cord-006229-7yoilsho	2334	4	.	.	.
cord-006229-7yoilsho	2335	1	In	in	IN
cord-006229-7yoilsho	2335	2	conclusion	conclusion	NN
cord-006229-7yoilsho	2335	3	,	,	,
cord-006229-7yoilsho	2335	4	Crataegus	Crataegus	NNP
cord-006229-7yoilsho	2335	5	extract	extract	NN
cord-006229-7yoilsho	2335	6	WS	WS	NNP
cord-006229-7yoilsho	2336	1	®	®	LS
cord-006229-7yoilsho	2336	2	1442	1442	CD
cord-006229-7yoilsho	2336	3	reverses	reverse	VBZ
cord-006229-7yoilsho	2336	4	obesity	obesity	NN
cord-006229-7yoilsho	2336	5	-	-	HYPH
cord-006229-7yoilsho	2336	6	induced	induce	VBN
cord-006229-7yoilsho	2336	7	vascular	vascular	JJ
cord-006229-7yoilsho	2336	8	dysfunction	dysfunction	NN
cord-006229-7yoilsho	2336	9	by	by	IN
cord-006229-7yoilsho	2336	10	improving	improve	VBG
cord-006229-7yoilsho	2336	11	PVAT	PVAT	NNP
cord-006229-7yoilsho	2336	12	function	function	NN
cord-006229-7yoilsho	2336	13	.	.	.
cord-006229-7yoilsho	2337	1	The	the	DT
cord-006229-7yoilsho	2337	2	molecular	molecular	JJ
cord-006229-7yoilsho	2337	3	mechanisms	mechanism	NNS
cord-006229-7yoilsho	2337	4	may	may	MD
cord-006229-7yoilsho	2337	5	involve	involve	VB
cord-006229-7yoilsho	2337	6	eNOS	enos	JJ
cord-006229-7yoilsho	2337	7	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	2337	8	at	at	IN
cord-006229-7yoilsho	2337	9	serine	serine	NN
cord-006229-7yoilsho	2337	10	1177	1177	CD
cord-006229-7yoilsho	2337	11	and	and	CC
cord-006229-7yoilsho	2337	12	upregulation	upregulation	NN
cord-006229-7yoilsho	2337	13	of	of	IN
cord-006229-7yoilsho	2337	14	SIRT1	SIRT1	NNS
cord-006229-7yoilsho	2337	15	.	.	.
cord-006229-7yoilsho	2338	1	The	the	DT
cord-006229-7yoilsho	2338	2	raf	raf	NNP
cord-006229-7yoilsho	2338	3	kinase	kinase	NN
cord-006229-7yoilsho	2338	4	inhibitor	inhibitor	NN
cord-006229-7yoilsho	2338	5	protein	protein	NN
cord-006229-7yoilsho	2338	6	(	(	-LRB-
cord-006229-7yoilsho	2338	7	RKIP	RKIP	NNP
cord-006229-7yoilsho	2338	8	)	)	-RRB-
cord-006229-7yoilsho	2338	9	inhibits	inhibit	VBZ
cord-006229-7yoilsho	2338	10	G	g	NN
cord-006229-7yoilsho	2338	11	-	-	HYPH
cord-006229-7yoilsho	2338	12	protein	protein	NN
cord-006229-7yoilsho	2338	13	-	-	HYPH
cord-006229-7yoilsho	2338	14	coupled	couple	VBN
cord-006229-7yoilsho	2338	15	receptor	receptor	NN
cord-006229-7yoilsho	2338	16	kinase	kinase	NN
cord-006229-7yoilsho	2338	17	(	(	-LRB-
cord-006229-7yoilsho	2338	18	GRK2	GRK2	NNP
cord-006229-7yoilsho	2338	19	)	)	-RRB-
cord-006229-7yoilsho	2338	20	and	and	CC
cord-006229-7yoilsho	2338	21	the	the	DT
cord-006229-7yoilsho	2338	22	RAF	RAF	NNP
cord-006229-7yoilsho	2338	23	-	-	HYPH
cord-006229-7yoilsho	2338	24	ERK1/2	ERK1/2	NNP
cord-006229-7yoilsho	2338	25	pathway	pathway	NN
cord-006229-7yoilsho	2338	26	.	.	.
cord-006229-7yoilsho	2339	1	These	these	DT
cord-006229-7yoilsho	2339	2	two	two	CD
cord-006229-7yoilsho	2339	3	functions	function	NNS
cord-006229-7yoilsho	2339	4	of	of	IN
cord-006229-7yoilsho	2339	5	RKIP	RKIP	NNP
cord-006229-7yoilsho	2339	6	could	could	MD
cord-006229-7yoilsho	2339	7	counteract	counteract	VB
cord-006229-7yoilsho	2339	8	each	each	DT
cord-006229-7yoilsho	2339	9	other	other	JJ
cord-006229-7yoilsho	2339	10	.	.	.
cord-006229-7yoilsho	2340	1	While	while	IN
cord-006229-7yoilsho	2340	2	GRK2	GRK2	NNP
cord-006229-7yoilsho	2340	3	inhibition	inhibition	NN
cord-006229-7yoilsho	2340	4	is	be	VBZ
cord-006229-7yoilsho	2340	5	cardio	cardio	JJ
cord-006229-7yoilsho	2340	6	-	-	HYPH
cord-006229-7yoilsho	2340	7	protective	protective	JJ
cord-006229-7yoilsho	2340	8	,	,	,
cord-006229-7yoilsho	2340	9	inhibition	inhibition	NN
cord-006229-7yoilsho	2340	10	of	of	IN
cord-006229-7yoilsho	2340	11	the	the	DT
cord-006229-7yoilsho	2340	12	pro	pro	JJ
cord-006229-7yoilsho	2340	13	-	-	JJ
cord-006229-7yoilsho	2340	14	survival	survival	JJ
cord-006229-7yoilsho	2341	1	ERK1/2	erk1/2	DT
cord-006229-7yoilsho	2341	2	axis	axis	NN
cord-006229-7yoilsho	2341	3	promotes	promote	VBZ
cord-006229-7yoilsho	2341	4	signs	sign	NNS
cord-006229-7yoilsho	2341	5	of	of	IN
cord-006229-7yoilsho	2341	6	heart	heart	NN
cord-006229-7yoilsho	2341	7	failure	failure	NN
cord-006229-7yoilsho	2341	8	in	in	IN
cord-006229-7yoilsho	2341	9	patients	patient	NNS
cord-006229-7yoilsho	2341	10	and	and	CC
cord-006229-7yoilsho	2341	11	experimental	experimental	JJ
cord-006229-7yoilsho	2341	12	models	model	NNS
cord-006229-7yoilsho	2341	13	.	.	.
cord-006229-7yoilsho	2342	1	In	in	IN
cord-006229-7yoilsho	2342	2	view	view	NN
cord-006229-7yoilsho	2342	3	of	of	IN
cord-006229-7yoilsho	2342	4	this	this	DT
cord-006229-7yoilsho	2342	5	ambivalent	ambivalent	JJ
cord-006229-7yoilsho	2342	6	nature	nature	NN
cord-006229-7yoilsho	2342	7	,	,	,
cord-006229-7yoilsho	2342	8	the	the	DT
cord-006229-7yoilsho	2342	9	function	function	NN
cord-006229-7yoilsho	2342	10	of	of	IN
cord-006229-7yoilsho	2342	11	RKIP	RKIP	NNP
cord-006229-7yoilsho	2342	12	in	in	IN
cord-006229-7yoilsho	2342	13	vivo	vivo	NN
cord-006229-7yoilsho	2342	14	is	be	VBZ
cord-006229-7yoilsho	2342	15	not	not	RB
cord-006229-7yoilsho	2342	16	clear	clear	JJ
cord-006229-7yoilsho	2342	17	.	.	.
cord-006229-7yoilsho	2343	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	2343	2	,	,	,
cord-006229-7yoilsho	2343	3	RKIP	RKIP	NNP
cord-006229-7yoilsho	2343	4	could	could	MD
cord-006229-7yoilsho	2343	5	have	have	VB
cord-006229-7yoilsho	2343	6	a	a	DT
cord-006229-7yoilsho	2343	7	pathophysiological	pathophysiological	JJ
cord-006229-7yoilsho	2343	8	role	role	NN
cord-006229-7yoilsho	2343	9	because	because	IN
cord-006229-7yoilsho	2343	10	heart	heart	NN
cord-006229-7yoilsho	2343	11	specimens	specimen	NNS
cord-006229-7yoilsho	2343	12	from	from	IN
cord-006229-7yoilsho	2343	13	patients	patient	NNS
cord-006229-7yoilsho	2343	14	with	with	IN
cord-006229-7yoilsho	2343	15	heart	heart	NN
cord-006229-7yoilsho	2343	16	failure	failure	NN
cord-006229-7yoilsho	2343	17	showed	show	VBD
cord-006229-7yoilsho	2343	18	RKIP	RKIP	NNP
cord-006229-7yoilsho	2343	19	up	up	IN
cord-006229-7yoilsho	2343	20	-	-	HYPH
cord-006229-7yoilsho	2343	21	regulation	regulation	NN
cord-006229-7yoilsho	2343	22	(	(	-LRB-
cord-006229-7yoilsho	2343	23	ref	ref	NN
cord-006229-7yoilsho	2343	24	.	.	NNP
cord-006229-7yoilsho	2343	25	1	1	CD
cord-006229-7yoilsho	2343	26	)	)	-RRB-
cord-006229-7yoilsho	2343	27	.	.	.
cord-006229-7yoilsho	2344	1	To	to	TO
cord-006229-7yoilsho	2344	2	investigate	investigate	VB
cord-006229-7yoilsho	2344	3	the	the	DT
cord-006229-7yoilsho	2344	4	impact	impact	NN
cord-006229-7yoilsho	2344	5	of	of	IN
cord-006229-7yoilsho	2344	6	cardiac	cardiac	JJ
cord-006229-7yoilsho	2344	7	RKIP	RKIP	NNP
cord-006229-7yoilsho	2344	8	upregulation	upregulation	NN
cord-006229-7yoilsho	2344	9	in	in	IN
cord-006229-7yoilsho	2344	10	vivo	vivo	NN
cord-006229-7yoilsho	2344	11	,	,	,
cord-006229-7yoilsho	2344	12	we	-PRON-	PRP
cord-006229-7yoilsho	2344	13	generated	generate	VBD
cord-006229-7yoilsho	2344	14	transgenic	transgenic	JJ
cord-006229-7yoilsho	2344	15	mice	mouse	NNS
cord-006229-7yoilsho	2344	16	with	with	IN
cord-006229-7yoilsho	2344	17	myocardium	myocardium	NN
cord-006229-7yoilsho	2344	18	-	-	HYPH
cord-006229-7yoilsho	2344	19	specific	specific	JJ
cord-006229-7yoilsho	2344	20	expression	expression	NN
cord-006229-7yoilsho	2344	21	of	of	IN
cord-006229-7yoilsho	2344	22	the	the	DT
cord-006229-7yoilsho	2344	23	human	human	JJ
cord-006229-7yoilsho	2344	24	RKIP	RKIP	NNP
cord-006229-7yoilsho	2344	25	gene	gene	NN
cord-006229-7yoilsho	2344	26	(	(	-LRB-
cord-006229-7yoilsho	2344	27	PEBP1	PEBP1	NNP
cord-006229-7yoilsho	2344	28	)	)	-RRB-
cord-006229-7yoilsho	2344	29	under	under	IN
cord-006229-7yoilsho	2344	30	control	control	NN
cord-006229-7yoilsho	2344	31	of	of	IN
cord-006229-7yoilsho	2344	32	the	the	DT
cord-006229-7yoilsho	2344	33	alpha	alpha	NN
cord-006229-7yoilsho	2344	34	-	-	HYPH
cord-006229-7yoilsho	2344	35	MHC	MHC	NNP
cord-006229-7yoilsho	2344	36	promoter	promoter	NN
cord-006229-7yoilsho	2344	37	.	.	.
cord-006229-7yoilsho	2345	1	Two	two	CD
cord-006229-7yoilsho	2345	2	different	different	JJ
cord-006229-7yoilsho	2345	3	RKIP	rkip	NN
cord-006229-7yoilsho	2345	4	-	-	HYPH
cord-006229-7yoilsho	2345	5	transgenic	transgenic	JJ
cord-006229-7yoilsho	2345	6	lines	line	NNS
cord-006229-7yoilsho	2345	7	with	with	IN
cord-006229-7yoilsho	2345	8	2.7-fold	2.7-fold	CD
cord-006229-7yoilsho	2345	9	and	and	CC
cord-006229-7yoilsho	2345	10	3.4-fold	3.4-fold	CD
cord-006229-7yoilsho	2345	11	increased	increase	VBD
cord-006229-7yoilsho	2346	1	cardiac	cardiac	JJ
cord-006229-7yoilsho	2346	2	RKIP	RKIP	NNP
cord-006229-7yoilsho	2346	3	protein	protein	NN
cord-006229-7yoilsho	2346	4	level	level	NN
cord-006229-7yoilsho	2346	5	were	be	VBD
cord-006229-7yoilsho	2346	6	generated	generate	VBN
cord-006229-7yoilsho	2346	7	(	(	-LRB-
cord-006229-7yoilsho	2346	8	ref	ref	NN
cord-006229-7yoilsho	2346	9	.	.	.
cord-006229-7yoilsho	2347	1	2	2	LS
cord-006229-7yoilsho	2347	2	,	,	,
cord-006229-7yoilsho	2347	3	and	and	CC
cord-006229-7yoilsho	2347	4	JAX	JAX	NNP
cord-006229-7yoilsho	2347	5	ID	ID	NNP
cord-006229-7yoilsho	2347	6	number	number	NN
cord-006229-7yoilsho	2347	7	911819	911819	CD
cord-006229-7yoilsho	2347	8	)	)	-RRB-
cord-006229-7yoilsho	2347	9	.	.	.
cord-006229-7yoilsho	2348	1	We	-PRON-	PRP
cord-006229-7yoilsho	2348	2	investigated	investigate	VBD
cord-006229-7yoilsho	2348	3	the	the	DT
cord-006229-7yoilsho	2348	4	cardiac	cardiac	JJ
cord-006229-7yoilsho	2348	5	phenotype	phenotype	NN
cord-006229-7yoilsho	2348	6	and	and	CC
cord-006229-7yoilsho	2348	7	found	find	VBD
cord-006229-7yoilsho	2348	8	that	that	IN
cord-006229-7yoilsho	2348	9	Tg	Tg	NNP
cord-006229-7yoilsho	2348	10	-	-	HYPH
cord-006229-7yoilsho	2348	11	RKIP	RKIP	NNP
cord-006229-7yoilsho	2348	12	mice	mouse	NNS
cord-006229-7yoilsho	2348	13	developed	develop	VBD
cord-006229-7yoilsho	2348	14	cardiac	cardiac	JJ
cord-006229-7yoilsho	2348	15	hypertrophy	hypertrophy	NN
cord-006229-7yoilsho	2348	16	with	with	IN
cord-006229-7yoilsho	2348	17	a	a	DT
cord-006229-7yoilsho	2348	18	significantly	significantly	RB
cord-006229-7yoilsho	2348	19	increased	increase	VBN
cord-006229-7yoilsho	2348	20	heart	heart	NN
cord-006229-7yoilsho	2348	21	weight	weight	NN
cord-006229-7yoilsho	2348	22	to	to	IN
cord-006229-7yoilsho	2348	23	body	body	NN
cord-006229-7yoilsho	2348	24	weight	weight	NN
cord-006229-7yoilsho	2348	25	ratio	ratio	NN
cord-006229-7yoilsho	2348	26	and	and	CC
cord-006229-7yoilsho	2348	27	a	a	DT
cord-006229-7yoilsho	2348	28	decreased	decrease	VBN
cord-006229-7yoilsho	2348	29	left	leave	VBN
cord-006229-7yoilsho	2348	30	ventricular	ventricular	JJ
cord-006229-7yoilsho	2348	31	ejection	ejection	NN
cord-006229-7yoilsho	2348	32	fraction	fraction	NN
cord-006229-7yoilsho	2348	33	relative	relative	JJ
cord-006229-7yoilsho	2348	34	to	to	IN
cord-006229-7yoilsho	2348	35	non	non	JJ
cord-006229-7yoilsho	2348	36	-	-	JJ
cord-006229-7yoilsho	2348	37	transgenic	transgenic	JJ
cord-006229-7yoilsho	2348	38	FVB	FVB	NNP
cord-006229-7yoilsho	2348	39	controls	control	NNS
cord-006229-7yoilsho	2348	40	,	,	,
cord-006229-7yoilsho	2348	41	as	as	RB
cord-006229-7yoilsho	2348	42	early	early	RB
cord-006229-7yoilsho	2348	43	as	as	IN
cord-006229-7yoilsho	2348	44	10	10	CD
cord-006229-7yoilsho	2348	45	weeks	week	NNS
cord-006229-7yoilsho	2348	46	of	of	IN
cord-006229-7yoilsho	2348	47	age	age	NN
cord-006229-7yoilsho	2348	48	.	.	.
cord-006229-7yoilsho	2349	1	Histology	histology	NN
cord-006229-7yoilsho	2349	2	analysis	analysis	NN
cord-006229-7yoilsho	2349	3	revealed	reveal	VBD
cord-006229-7yoilsho	2349	4	progressive	progressive	JJ
cord-006229-7yoilsho	2349	5	atrial	atrial	JJ
cord-006229-7yoilsho	2349	6	and	and	CC
cord-006229-7yoilsho	2349	7	ventricular	ventricular	JJ
cord-006229-7yoilsho	2349	8	enlargement	enlargement	NN
cord-006229-7yoilsho	2349	9	of	of	IN
cord-006229-7yoilsho	2349	10	Tg	Tg	NNP
cord-006229-7yoilsho	2349	11	-	-	HYPH
cord-006229-7yoilsho	2349	12	RKIP	RKIP	NNP
cord-006229-7yoilsho	2349	13	hearts	heart	NNS
cord-006229-7yoilsho	2349	14	.	.	.
cord-006229-7yoilsho	2350	1	ECG	ECG	NNP
cord-006229-7yoilsho	2350	2	abnormalities	abnormality	NNS
cord-006229-7yoilsho	2350	3	,	,	,
cord-006229-7yoilsho	2350	4	a	a	DT
cord-006229-7yoilsho	2350	5	lower	low	JJR
cord-006229-7yoilsho	2350	6	maximum	maximum	JJ
cord-006229-7yoilsho	2350	7	rate	rate	NN
cord-006229-7yoilsho	2350	8	of	of	IN
cord-006229-7yoilsho	2350	9	left	left	JJ
cord-006229-7yoilsho	2350	10	ventricular	ventricular	JJ
cord-006229-7yoilsho	2350	11	pressure	pressure	NN
cord-006229-7yoilsho	2350	12	rise	rise	NN
cord-006229-7yoilsho	2350	13	,	,	,
cord-006229-7yoilsho	2350	14	and	and	CC
cord-006229-7yoilsho	2350	15	a	a	DT
cord-006229-7yoilsho	2350	16	strongly	strongly	RB
cord-006229-7yoilsho	2350	17	decreased	decrease	VBN
cord-006229-7yoilsho	2350	18	left	leave	VBN
cord-006229-7yoilsho	2350	19	ventricular	ventricular	JJ
cord-006229-7yoilsho	2350	20	ejection	ejection	NN
cord-006229-7yoilsho	2350	21	fraction	fraction	NN
cord-006229-7yoilsho	2350	22	of	of	IN
cord-006229-7yoilsho	2350	23	32.9±2.3	32.9±2.3	CD
cord-006229-7yoilsho	2350	24	%	%	NN
cord-006229-7yoilsho	2350	25	(	(	-LRB-
cord-006229-7yoilsho	2350	26	n=6	n=6	NNP
cord-006229-7yoilsho	2350	27	;	;	:
cord-006229-7yoilsho	2350	28	±s.d	±s.d	NNP
cord-006229-7yoilsho	2350	29	.	.	.
cord-006229-7yoilsho	2350	30	)	)	-RRB-
cord-006229-7yoilsho	2350	31	were	be	VBD
cord-006229-7yoilsho	2350	32	documented	document	VBN
cord-006229-7yoilsho	2350	33	at	at	IN
cord-006229-7yoilsho	2350	34	an	an	DT
cord-006229-7yoilsho	2350	35	age	age	NN
cord-006229-7yoilsho	2350	36	of	of	IN
cord-006229-7yoilsho	2350	37	8	8	CD
cord-006229-7yoilsho	2350	38	months	month	NNS
cord-006229-7yoilsho	2350	39	.	.	.
cord-006229-7yoilsho	2351	1	Down	down	IN
cord-006229-7yoilsho	2351	2	-	-	HYPH
cord-006229-7yoilsho	2351	3	regulation	regulation	NN
cord-006229-7yoilsho	2351	4	of	of	IN
cord-006229-7yoilsho	2351	5	the	the	DT
cord-006229-7yoilsho	2351	6	transgenic	transgenic	JJ
cord-006229-7yoilsho	2351	7	RKIP	RKIP	NNS
cord-006229-7yoilsho	2351	8	by	by	IN
cord-006229-7yoilsho	2351	9	lentiviral	lentiviral	JJ
cord-006229-7yoilsho	2351	10	transduction	transduction	NN
cord-006229-7yoilsho	2351	11	of	of	IN
cord-006229-7yoilsho	2351	12	an	an	DT
cord-006229-7yoilsho	2351	13	RKIP	RKIP	NNP
cord-006229-7yoilsho	2351	14	-	-	HYPH
cord-006229-7yoilsho	2351	15	targeting	target	VBG
cord-006229-7yoilsho	2351	16	miRNA	miRNA	NNP
cord-006229-7yoilsho	2351	17	retarded	retard	VBD
cord-006229-7yoilsho	2351	18	the	the	DT
cord-006229-7yoilsho	2351	19	cardiac	cardiac	JJ
cord-006229-7yoilsho	2351	20	phenotype	phenotype	NN
cord-006229-7yoilsho	2351	21	of	of	IN
cord-006229-7yoilsho	2351	22	Tg	Tg	NNP
cord-006229-7yoilsho	2351	23	-	-	HYPH
cord-006229-7yoilsho	2351	24	RKIP	RKIP	NNP
cord-006229-7yoilsho	2351	25	mice	mouse	NNS
cord-006229-7yoilsho	2351	26	.	.	.
cord-006229-7yoilsho	2352	1	Thus	thus	RB
cord-006229-7yoilsho	2352	2	,	,	,
cord-006229-7yoilsho	2352	3	dual	dual	JJ
cord-006229-7yoilsho	2352	4	-	-	HYPH
cord-006229-7yoilsho	2352	5	specific	specific	JJ
cord-006229-7yoilsho	2352	6	inhibition	inhibition	NN
cord-006229-7yoilsho	2352	7	of	of	IN
cord-006229-7yoilsho	2352	8	the	the	DT
cord-006229-7yoilsho	2352	9	GRK2	GRK2	NNP
cord-006229-7yoilsho	2352	10	and	and	CC
cord-006229-7yoilsho	2352	11	RAF	RAF	NNP
cord-006229-7yoilsho	2352	12	-	-	HYPH
cord-006229-7yoilsho	2352	13	ERK1/2	ERK1/2	NNP
cord-006229-7yoilsho	2352	14	axis	axis	NN
cord-006229-7yoilsho	2352	15	by	by	IN
cord-006229-7yoilsho	2352	16	the	the	DT
cord-006229-7yoilsho	2352	17	human	human	JJ
cord-006229-7yoilsho	2352	18	RKIP	RKIP	NNP
cord-006229-7yoilsho	2352	19	gene	gene	NN
cord-006229-7yoilsho	2352	20	(	(	-LRB-
cord-006229-7yoilsho	2352	21	PEBP1	PEBP1	NNP
cord-006229-7yoilsho	2352	22	)	)	-RRB-
cord-006229-7yoilsho	2352	23	triggers	trigger	VBZ
cord-006229-7yoilsho	2352	24	signs	sign	NNS
cord-006229-7yoilsho	2352	25	of	of	IN
cord-006229-7yoilsho	2352	26	heart	heart	NN
cord-006229-7yoilsho	2352	27	failure	failure	NN
cord-006229-7yoilsho	2352	28	in	in	IN
cord-006229-7yoilsho	2352	29	vivo	vivo	NN
cord-006229-7yoilsho	2352	30	,	,	,
cord-006229-7yoilsho	2352	31	and	and	CC
cord-006229-7yoilsho	2352	32	the	the	DT
cord-006229-7yoilsho	2352	33	documented	document	VBN
cord-006229-7yoilsho	2352	34	upregulation	upregulation	NN
cord-006229-7yoilsho	2352	35	of	of	IN
cord-006229-7yoilsho	2352	36	the	the	DT
cord-006229-7yoilsho	2352	37	cardiac	cardiac	JJ
cord-006229-7yoilsho	2352	38	RKIP	rkip	NN
cord-006229-7yoilsho	2352	39	in	in	IN
cord-006229-7yoilsho	2352	40	heart	heart	NN
cord-006229-7yoilsho	2352	41	failure	failure	NN
cord-006229-7yoilsho	2352	42	patients	patient	NNS
cord-006229-7yoilsho	2352	43	could	could	MD
cord-006229-7yoilsho	2352	44	aggravate	aggravate	VB
cord-006229-7yoilsho	2352	45	disease	disease	NN
cord-006229-7yoilsho	2352	46	pathogenesis	pathogenesis	NN
cord-006229-7yoilsho	2352	47	.	.	.
cord-006229-7yoilsho	2353	1	These	these	DT
cord-006229-7yoilsho	2353	2	findings	finding	NNS
cord-006229-7yoilsho	2353	3	are	be	VBP
cord-006229-7yoilsho	2353	4	in	in	IN
cord-006229-7yoilsho	2353	5	contrast	contrast	NN
cord-006229-7yoilsho	2353	6	to	to	IN
cord-006229-7yoilsho	2353	7	rodent	rodent	NN
cord-006229-7yoilsho	2353	8	RKIP	RKIP	NNP
cord-006229-7yoilsho	2353	9	(	(	-LRB-
cord-006229-7yoilsho	2353	10	Pebp1	Pebp1	NNP
cord-006229-7yoilsho	2353	11	)	)	-RRB-
cord-006229-7yoilsho	2353	12	,	,	,
cord-006229-7yoilsho	2353	13	which	which	WDT
cord-006229-7yoilsho	2353	14	does	do	VBZ
cord-006229-7yoilsho	2353	15	not	not	RB
cord-006229-7yoilsho	2353	16	seem	seem	VB
cord-006229-7yoilsho	2353	17	to	to	TO
cord-006229-7yoilsho	2353	18	inhibit	inhibit	VB
cord-006229-7yoilsho	2353	19	the	the	DT
cord-006229-7yoilsho	2353	20	Raf	Raf	NNP
cord-006229-7yoilsho	2353	21	-	-	HYPH
cord-006229-7yoilsho	2353	22	ERK1/2	ERK1/2	NNP
cord-006229-7yoilsho	2353	23	axis	axis	NN
cord-006229-7yoilsho	2353	24	in	in	IN
cord-006229-7yoilsho	2353	25	vivo	vivo	NN
cord-006229-7yoilsho	2353	26	but	but	CC
cord-006229-7yoilsho	2353	27	instead	instead	RB
cord-006229-7yoilsho	2353	28	confers	confer	VBZ
cord-006229-7yoilsho	2353	29	GRK2	GRK2	NNP
cord-006229-7yoilsho	2353	30	inhibition-	inhibition-	NN
cord-006229-7yoilsho	2353	31	Heterodimerization	Heterodimerization	NNP
cord-006229-7yoilsho	2353	32	between	between	IN
cord-006229-7yoilsho	2353	33	the	the	DT
cord-006229-7yoilsho	2353	34	AT1	AT1	NNP
cord-006229-7yoilsho	2353	35	receptor	receptor	NN
cord-006229-7yoilsho	2353	36	(	(	-LRB-
cord-006229-7yoilsho	2353	37	AT1R	AT1R	NNP
cord-006229-7yoilsho	2353	38	)	)	-RRB-
cord-006229-7yoilsho	2353	39	for	for	IN
cord-006229-7yoilsho	2353	40	the	the	DT
cord-006229-7yoilsho	2353	41	vasopressor	vasopressor	NN
cord-006229-7yoilsho	2353	42	peptide	peptide	NN
cord-006229-7yoilsho	2353	43	,	,	,
cord-006229-7yoilsho	2353	44	angiotensin	angiotensin	NN
cord-006229-7yoilsho	2353	45	II	II	NNP
cord-006229-7yoilsho	2353	46	,	,	,
cord-006229-7yoilsho	2353	47	and	and	CC
cord-006229-7yoilsho	2353	48	the	the	DT
cord-006229-7yoilsho	2353	49	B2	b2	NN
cord-006229-7yoilsho	2353	50	receptor	receptor	NN
cord-006229-7yoilsho	2353	51	(	(	-LRB-
cord-006229-7yoilsho	2353	52	B2R	b2r	NN
cord-006229-7yoilsho	2353	53	)	)	-RRB-
cord-006229-7yoilsho	2353	54	for	for	IN
cord-006229-7yoilsho	2353	55	the	the	DT
cord-006229-7yoilsho	2353	56	vasodepressor	vasodepressor	NNP
cord-006229-7yoilsho	2353	57	peptide	peptide	NN
cord-006229-7yoilsho	2353	58	,	,	,
cord-006229-7yoilsho	2353	59	bradykinin	bradykinin	NN
cord-006229-7yoilsho	2353	60	,	,	,
cord-006229-7yoilsho	2353	61	enhances	enhance	VBZ
cord-006229-7yoilsho	2353	62	angiotensin	angiotensin	NN
cord-006229-7yoilsho	2353	63	II	II	NNP
cord-006229-7yoilsho	2353	64	-	-	HYPH
cord-006229-7yoilsho	2353	65	stimulated	stimulate	VBN
cord-006229-7yoilsho	2353	66	signalling	signalling	NN
cord-006229-7yoilsho	2353	67	in	in	IN
cord-006229-7yoilsho	2353	68	cells	cell	NNS
cord-006229-7yoilsho	2353	69	.	.	.
cord-006229-7yoilsho	2354	1	In	in	IN
cord-006229-7yoilsho	2354	2	addition	addition	NN
cord-006229-7yoilsho	2354	3	,	,	,
cord-006229-7yoilsho	2354	4	AT1R	AT1R	NNP
cord-006229-7yoilsho	2354	5	--	--	:
cord-006229-7yoilsho	2354	6	B2R	B2R	NNP
cord-006229-7yoilsho	2354	7	heterodimerization	heterodimerization	NNP
cord-006229-7yoilsho	2354	8	has	have	VBZ
cord-006229-7yoilsho	2354	9	a	a	DT
cord-006229-7yoilsho	2354	10	major	major	JJ
cord-006229-7yoilsho	2354	11	pathophysiological	pathophysiological	JJ
cord-006229-7yoilsho	2354	12	role	role	NN
cord-006229-7yoilsho	2354	13	and	and	CC
cord-006229-7yoilsho	2354	14	contributes	contribute	VBZ
cord-006229-7yoilsho	2354	15	to	to	IN
cord-006229-7yoilsho	2354	16	the	the	DT
cord-006229-7yoilsho	2354	17	angiotensin	angiotensin	NN
cord-006229-7yoilsho	2354	18	II	ii	CD
cord-006229-7yoilsho	2354	19	hypersensitivity	hypersensitivity	NN
cord-006229-7yoilsho	2354	20	in	in	IN
cord-006229-7yoilsho	2354	21	women	woman	NNS
cord-006229-7yoilsho	2354	22	with	with	IN
cord-006229-7yoilsho	2354	23	preeclampsia	preeclampsia	JJ
cord-006229-7yoilsho	2354	24	hypertension	hypertension	NN
cord-006229-7yoilsho	2354	25	.	.	.
cord-006229-7yoilsho	2355	1	To	to	TO
cord-006229-7yoilsho	2355	2	analyse	analyse	VB
cord-006229-7yoilsho	2355	3	the	the	DT
cord-006229-7yoilsho	2355	4	vascular	vascular	JJ
cord-006229-7yoilsho	2355	5	function	function	NN
cord-006229-7yoilsho	2355	6	of	of	IN
cord-006229-7yoilsho	2355	7	the	the	DT
cord-006229-7yoilsho	2355	8	AT1R	AT1R	NNP
cord-006229-7yoilsho	2355	9	--	--	:
cord-006229-7yoilsho	2355	10	B2R	b2r	IN
cord-006229-7yoilsho	2355	11	heterodimer	heterodimer	NN
cord-006229-7yoilsho	2355	12	in	in	IN
cord-006229-7yoilsho	2355	13	vivo	vivo	NNP
cord-006229-7yoilsho	2355	14	,	,	,
cord-006229-7yoilsho	2355	15	we	-PRON-	PRP
cord-006229-7yoilsho	2355	16	generated	generate	VBD
cord-006229-7yoilsho	2355	17	a	a	DT
cord-006229-7yoilsho	2355	18	transgenic	transgenic	JJ
cord-006229-7yoilsho	2355	19	model	model	NN
cord-006229-7yoilsho	2355	20	of	of	IN
cord-006229-7yoilsho	2355	21	AT1R	AT1R	NNP
cord-006229-7yoilsho	2355	22	--	--	:
cord-006229-7yoilsho	2355	23	B2R	b2r	CC
cord-006229-7yoilsho	2355	24	heterodimerization	heterodimerization	NNP
cord-006229-7yoilsho	2355	25	(	(	-LRB-
cord-006229-7yoilsho	2355	26	Tg	Tg	NNP
cord-006229-7yoilsho	2355	27	-	-	HYPH
cord-006229-7yoilsho	2355	28	B2R+	B2R+	NNP
cord-006229-7yoilsho	2355	29	)	)	-RRB-
cord-006229-7yoilsho	2355	30	by	by	IN
cord-006229-7yoilsho	2355	31	transgenic	transgenic	JJ
cord-006229-7yoilsho	2355	32	expression	expression	NN
cord-006229-7yoilsho	2355	33	of	of	IN
cord-006229-7yoilsho	2355	34	the	the	DT
cord-006229-7yoilsho	2355	35	B2R	B2R	NNP
cord-006229-7yoilsho	2355	36	gene	gene	NN
cord-006229-7yoilsho	2355	37	(	(	-LRB-
cord-006229-7yoilsho	2355	38	BDKRB2	BDKRB2	NNP
cord-006229-7yoilsho	2355	39	)	)	-RRB-
cord-006229-7yoilsho	2355	40	in	in	IN
cord-006229-7yoilsho	2355	41	the	the	DT
cord-006229-7yoilsho	2355	42	B2R	b2r	JJ
cord-006229-7yoilsho	2355	43	-	-	HYPH
cord-006229-7yoilsho	2355	44	deficient	deficient	JJ
cord-006229-7yoilsho	2355	45	Tg	Tg	NNP
cord-006229-7yoilsho	2355	46	-	-	HYPH
cord-006229-7yoilsho	2355	47	B2R-/-strain	B2R-/-strain	NNP
cord-006229-7yoilsho	2355	48	.	.	.
cord-006229-7yoilsho	2356	1	Fluorescence	fluorescence	NN
cord-006229-7yoilsho	2356	2	resonance	resonance	NN
cord-006229-7yoilsho	2356	3	energy	energy	NN
cord-006229-7yoilsho	2356	4	transfer	transfer	NN
cord-006229-7yoilsho	2356	5	(	(	-LRB-
cord-006229-7yoilsho	2356	6	FRET	fret	NN
cord-006229-7yoilsho	2356	7	)	)	-RRB-
cord-006229-7yoilsho	2357	1	imaging	imaging	NN
cord-006229-7yoilsho	2357	2	was	be	VBD
cord-006229-7yoilsho	2357	3	applied	apply	VBN
cord-006229-7yoilsho	2357	4	to	to	TO
cord-006229-7yoilsho	2357	5	analyse	analyse	VB
cord-006229-7yoilsho	2357	6	the	the	DT
cord-006229-7yoilsho	2357	7	interaction	interaction	NN
cord-006229-7yoilsho	2357	8	between	between	IN
cord-006229-7yoilsho	2357	9	different	different	JJ
cord-006229-7yoilsho	2357	10	Gprotein	Gprotein	NNP
cord-006229-7yoilsho	2357	11	-	-	HYPH
cord-006229-7yoilsho	2357	12	coupled	couple	VBN
cord-006229-7yoilsho	2357	13	receptors	receptor	NNS
cord-006229-7yoilsho	2357	14	in	in	IN
cord-006229-7yoilsho	2357	15	the	the	DT
cord-006229-7yoilsho	2357	16	aorta	aorta	NN
cord-006229-7yoilsho	2357	17	of	of	IN
cord-006229-7yoilsho	2357	18	transgenic	transgenic	JJ
cord-006229-7yoilsho	2357	19	mice	mouse	NNS
cord-006229-7yoilsho	2357	20	.	.	.
cord-006229-7yoilsho	2358	1	We	-PRON-	PRP
cord-006229-7yoilsho	2358	2	report	report	VBP
cord-006229-7yoilsho	2358	3	here	here	RB
cord-006229-7yoilsho	2358	4	that	that	IN
cord-006229-7yoilsho	2358	5	FRET	fret	NN
cord-006229-7yoilsho	2358	6	imaging	imaging	NN
cord-006229-7yoilsho	2358	7	detected	detect	VBD
cord-006229-7yoilsho	2358	8	the	the	DT
cord-006229-7yoilsho	2358	9	close	close	JJ
cord-006229-7yoilsho	2358	10	interaction	interaction	NN
cord-006229-7yoilsho	2358	11	between	between	IN
cord-006229-7yoilsho	2358	12	the	the	DT
cord-006229-7yoilsho	2358	13	aortic	aortic	JJ
cord-006229-7yoilsho	2358	14	AT1R	AT1R	NNP
cord-006229-7yoilsho	2358	15	and	and	CC
cord-006229-7yoilsho	2358	16	B2R	b2r	NN
cord-006229-7yoilsho	2358	17	at	at	IN
cord-006229-7yoilsho	2358	18	a	a	DT
cord-006229-7yoilsho	2358	19	distance	distance	NN
cord-006229-7yoilsho	2358	20	of	of	IN
cord-006229-7yoilsho	2358	21	less	less	JJR
cord-006229-7yoilsho	2358	22	than	than	IN
cord-006229-7yoilsho	2358	23	9	9	CD
cord-006229-7yoilsho	2358	24	nm	nm	NN
cord-006229-7yoilsho	2358	25	in	in	IN
cord-006229-7yoilsho	2358	26	Tg	Tg	NNP
cord-006229-7yoilsho	2358	27	-	-	HYPH
cord-006229-7yoilsho	2358	28	B2R+	B2R+	NNP
cord-006229-7yoilsho	2358	29	mice	mouse	NNS
cord-006229-7yoilsho	2358	30	whereas	whereas	IN
cord-006229-7yoilsho	2358	31	the	the	DT
cord-006229-7yoilsho	2358	32	AT1R	AT1R	NNP
cord-006229-7yoilsho	2358	33	--	--	:
cord-006229-7yoilsho	2358	34	B2R	B2R	NNP
cord-006229-7yoilsho	2358	35	heterodimer	heterodimer	NNP
cord-006229-7yoilsho	2358	36	was	be	VBD
cord-006229-7yoilsho	2358	37	absent	absent	JJ
cord-006229-7yoilsho	2358	38	in	in	IN
cord-006229-7yoilsho	2358	39	Tg	Tg	NNP
cord-006229-7yoilsho	2358	40	-	-	HYPH
cord-006229-7yoilsho	2358	41	B2R-/-mice	B2R-/-mice	NNP
cord-006229-7yoilsho	2358	42	.	.	.
cord-006229-7yoilsho	2359	1	In	in	IN
cord-006229-7yoilsho	2359	2	contrast	contrast	NN
cord-006229-7yoilsho	2359	3	,	,	,
cord-006229-7yoilsho	2359	4	FRET	FRET	NNP
cord-006229-7yoilsho	2359	5	was	be	VBD
cord-006229-7yoilsho	2359	6	not	not	RB
cord-006229-7yoilsho	2359	7	detectable	detectable	JJ
cord-006229-7yoilsho	2359	8	between	between	IN
cord-006229-7yoilsho	2359	9	the	the	DT
cord-006229-7yoilsho	2359	10	endothelin	endothelin	NN
cord-006229-7yoilsho	2359	11	ETA	ETA	NNP
cord-006229-7yoilsho	2359	12	receptor	receptor	NN
cord-006229-7yoilsho	2359	13	(	(	-LRB-
cord-006229-7yoilsho	2359	14	ETAR	ETAR	NNP
cord-006229-7yoilsho	2359	15	)	)	-RRB-
cord-006229-7yoilsho	2359	16	and	and	CC
cord-006229-7yoilsho	2359	17	the	the	DT
cord-006229-7yoilsho	2359	18	B2R	b2r	NN
cord-006229-7yoilsho	2359	19	in	in	IN
cord-006229-7yoilsho	2359	20	the	the	DT
cord-006229-7yoilsho	2359	21	aorta	aorta	NN
cord-006229-7yoilsho	2359	22	of	of	IN
cord-006229-7yoilsho	2359	23	Tg	Tg	NNP
cord-006229-7yoilsho	2359	24	-	-	HYPH
cord-006229-7yoilsho	2359	25	B2R+	B2R+	NNP
cord-006229-7yoilsho	2359	26	mice	mouse	NNS
cord-006229-7yoilsho	2359	27	,	,	,
cord-006229-7yoilsho	2359	28	although	although	IN
cord-006229-7yoilsho	2359	29	immunofluorescence	immunofluorescence	NN
cord-006229-7yoilsho	2359	30	and	and	CC
cord-006229-7yoilsho	2359	31	immunohistology	immunohistology	NN
cord-006229-7yoilsho	2359	32	confirmed	confirm	VBD
cord-006229-7yoilsho	2359	33	the	the	DT
cord-006229-7yoilsho	2359	34	aortic	aortic	NN
cord-006229-7yoilsho	2359	35	(	(	-LRB-
cord-006229-7yoilsho	2359	36	co-)-localization	co-)-localization	NN
cord-006229-7yoilsho	2359	37	of	of	IN
cord-006229-7yoilsho	2359	38	both	both	DT
cord-006229-7yoilsho	2359	39	,	,	,
cord-006229-7yoilsho	2359	40	ETAR	ETAR	NNP
cord-006229-7yoilsho	2359	41	and	and	CC
cord-006229-7yoilsho	2359	42	B2R.	B2R.	NNP
cord-006229-7yoilsho	2360	1	The	the	DT
cord-006229-7yoilsho	2360	2	efficient	efficient	JJ
cord-006229-7yoilsho	2360	3	AT1R	AT1R	NNS
cord-006229-7yoilsho	2360	4	--	--	:
cord-006229-7yoilsho	2360	5	B2R	b2r	IN
cord-006229-7yoilsho	2360	6	heterodimerization	heterodimerization	NN
cord-006229-7yoilsho	2360	7	in	in	IN
cord-006229-7yoilsho	2360	8	Tg	Tg	NNP
cord-006229-7yoilsho	2360	9	-	-	HYPH
cord-006229-7yoilsho	2360	10	B2R+	B2R+	NNP
cord-006229-7yoilsho	2360	11	mice	mouse	NNS
cord-006229-7yoilsho	2360	12	was	be	VBD
cord-006229-7yoilsho	2360	13	accompanied	accompany	VBN
cord-006229-7yoilsho	2360	14	by	by	IN
cord-006229-7yoilsho	2360	15	an	an	DT
cord-006229-7yoilsho	2360	16	enhanced	enhance	VBN
cord-006229-7yoilsho	2360	17	angiotensin	angiotensin	NN
cord-006229-7yoilsho	2360	18	II	ii	CD
cord-006229-7yoilsho	2360	19	AT1R	AT1R	NNP
cord-006229-7yoilsho	2360	20	-	-	HYPH
cord-006229-7yoilsho	2360	21	stimulated	stimulate	VBN
cord-006229-7yoilsho	2360	22	vasopressor	vasopressor	NN
cord-006229-7yoilsho	2360	23	response	response	NN
cord-006229-7yoilsho	2360	24	relative	relative	JJ
cord-006229-7yoilsho	2360	25	to	to	IN
cord-006229-7yoilsho	2360	26	that	that	DT
cord-006229-7yoilsho	2360	27	of	of	IN
cord-006229-7yoilsho	2360	28	Tg	Tg	NNP
cord-006229-7yoilsho	2360	29	-	-	HYPH
cord-006229-7yoilsho	2360	30	B2-/-mice	B2-/-mice	NNP
cord-006229-7yoilsho	2360	31	,	,	,
cord-006229-7yoilsho	2360	32	which	which	WDT
cord-006229-7yoilsho	2360	33	lack	lack	VBP
cord-006229-7yoilsho	2360	34	the	the	DT
cord-006229-7yoilsho	2360	35	AT1R	AT1R	NNP
cord-006229-7yoilsho	2360	36	--	--	:
cord-006229-7yoilsho	2360	37	B2R	B2R	NNP
cord-006229-7yoilsho	2360	38	heterodimer	heterodimer	NNP
cord-006229-7yoilsho	2360	39	.	.	.
cord-006229-7yoilsho	2361	1	As	as	IN
cord-006229-7yoilsho	2361	2	a	a	DT
cord-006229-7yoilsho	2361	3	control	control	NN
cord-006229-7yoilsho	2361	4	,	,	,
cord-006229-7yoilsho	2361	5	the	the	DT
cord-006229-7yoilsho	2361	6	endothelin-1-stimulated	endothelin-1-stimulated	JJ
cord-006229-7yoilsho	2361	7	vasopressor	vasopressor	NN
cord-006229-7yoilsho	2361	8	response	response	NN
cord-006229-7yoilsho	2361	9	mediated	mediate	VBN
cord-006229-7yoilsho	2361	10	by	by	IN
cord-006229-7yoilsho	2361	11	the	the	DT
cord-006229-7yoilsho	2361	12	ETAR	ETAR	NNP
cord-006229-7yoilsho	2361	13	,	,	,
cord-006229-7yoilsho	2361	14	which	which	WDT
cord-006229-7yoilsho	2361	15	did	do	VBD
cord-006229-7yoilsho	2361	16	not	not	RB
cord-006229-7yoilsho	2361	17	dimerize	dimerize	VB
cord-006229-7yoilsho	2361	18	with	with	IN
cord-006229-7yoilsho	2361	19	B2R	B2R	NNP
cord-006229-7yoilsho	2361	20	,	,	,
cord-006229-7yoilsho	2361	21	was	be	VBD
cord-006229-7yoilsho	2361	22	not	not	RB
cord-006229-7yoilsho	2361	23	significantly	significantly	RB
cord-006229-7yoilsho	2361	24	different	different	JJ
cord-006229-7yoilsho	2361	25	between	between	IN
cord-006229-7yoilsho	2361	26	Tg	Tg	NNP
cord-006229-7yoilsho	2361	27	-	-	HYPH
cord-006229-7yoilsho	2361	28	B2R+	B2R+	NNP
cord-006229-7yoilsho	2361	29	and	and	CC
cord-006229-7yoilsho	2361	30	Tg	Tg	NNP
cord-006229-7yoilsho	2361	31	-	-	HYPH
cord-006229-7yoilsho	2361	32	B2R-/-mice	B2R-/-mice	NNP
cord-006229-7yoilsho	2361	33	.	.	.
cord-006229-7yoilsho	2362	1	Together	together	RB
cord-006229-7yoilsho	2362	2	these	these	DT
cord-006229-7yoilsho	2362	3	findings	finding	NNS
cord-006229-7yoilsho	2362	4	provide	provide	VBP
cord-006229-7yoilsho	2362	5	strong	strong	JJ
cord-006229-7yoilsho	2362	6	evidence	evidence	NN
cord-006229-7yoilsho	2362	7	that	that	IN
cord-006229-7yoilsho	2362	8	AT1R--	at1r--	NN
cord-006229-7yoilsho	2363	1	B2R	b2r	CC
cord-006229-7yoilsho	2363	2	heterodimerization	heterodimerization	NNP
cord-006229-7yoilsho	2363	3	occurs	occur	VBZ
cord-006229-7yoilsho	2363	4	in	in	IN
cord-006229-7yoilsho	2363	5	vivo	vivo	NN
cord-006229-7yoilsho	2363	6	and	and	CC
cord-006229-7yoilsho	2363	7	enhances	enhance	VBZ
cord-006229-7yoilsho	2363	8	the	the	DT
cord-006229-7yoilsho	2363	9	angiotensin	angiotensin	NN
cord-006229-7yoilsho	2363	10	II	II	NNP
cord-006229-7yoilsho	2363	11	AT1R	AT1R	NNP
cord-006229-7yoilsho	2363	12	-	-	HYPH
cord-006229-7yoilsho	2363	13	stimulated	stimulate	VBN
cord-006229-7yoilsho	2363	14	vasopressor	vasopressor	NN
cord-006229-7yoilsho	2363	15	response	response	NN
cord-006229-7yoilsho	2363	16	.	.	.
cord-006229-7yoilsho	2364	1	Dysfunction	dysfunction	NN
cord-006229-7yoilsho	2364	2	of	of	IN
cord-006229-7yoilsho	2364	3	the	the	DT
cord-006229-7yoilsho	2364	4	cardiac	cardiac	JJ
cord-006229-7yoilsho	2364	5	energy	energy	NN
cord-006229-7yoilsho	2364	6	substrate	substrate	NN
cord-006229-7yoilsho	2364	7	metabolism	metabolism	NN
cord-006229-7yoilsho	2364	8	is	be	VBZ
cord-006229-7yoilsho	2364	9	a	a	DT
cord-006229-7yoilsho	2364	10	characteristic	characteristic	JJ
cord-006229-7yoilsho	2364	11	feature	feature	NN
cord-006229-7yoilsho	2364	12	of	of	IN
cord-006229-7yoilsho	2364	13	late	late	JJ
cord-006229-7yoilsho	2364	14	-	-	HYPH
cord-006229-7yoilsho	2364	15	stage	stage	NN
cord-006229-7yoilsho	2364	16	heart	heart	NN
cord-006229-7yoilsho	2364	17	failure	failure	NN
cord-006229-7yoilsho	2364	18	.	.	.
cord-006229-7yoilsho	2365	1	The	the	DT
cord-006229-7yoilsho	2365	2	dysfunctional	dysfunctional	JJ
cord-006229-7yoilsho	2365	3	cardiac	cardiac	JJ
cord-006229-7yoilsho	2365	4	substrate	substrate	NN
cord-006229-7yoilsho	2365	5	metabolism	metabolism	NN
cord-006229-7yoilsho	2365	6	contributes	contribute	VBZ
cord-006229-7yoilsho	2365	7	to	to	IN
cord-006229-7yoilsho	2365	8	insufficient	insufficient	JJ
cord-006229-7yoilsho	2365	9	energy	energy	NN
cord-006229-7yoilsho	2365	10	generation	generation	NN
cord-006229-7yoilsho	2365	11	and	and	CC
cord-006229-7yoilsho	2365	12	has	have	VBZ
cord-006229-7yoilsho	2365	13	limited	limit	VBN
cord-006229-7yoilsho	2365	14	treatment	treatment	NN
cord-006229-7yoilsho	2365	15	options	option	NNS
cord-006229-7yoilsho	2365	16	.	.	.
cord-006229-7yoilsho	2366	1	In	in	IN
cord-006229-7yoilsho	2366	2	search	search	NN
cord-006229-7yoilsho	2366	3	for	for	IN
cord-006229-7yoilsho	2366	4	a	a	DT
cord-006229-7yoilsho	2366	5	treatment	treatment	NN
cord-006229-7yoilsho	2366	6	approach	approach	NN
cord-006229-7yoilsho	2366	7	,	,	,
cord-006229-7yoilsho	2366	8	we	-PRON-	PRP
cord-006229-7yoilsho	2366	9	investigated	investigate	VBD
cord-006229-7yoilsho	2366	10	whether	whether	IN
cord-006229-7yoilsho	2366	11	inhibition	inhibition	NN
cord-006229-7yoilsho	2366	12	of	of	IN
cord-006229-7yoilsho	2366	13	G	g	NN
cord-006229-7yoilsho	2366	14	-	-	HYPH
cord-006229-7yoilsho	2366	15	protein	protein	NN
cord-006229-7yoilsho	2366	16	-	-	HYPH
cord-006229-7yoilsho	2366	17	coupled	couple	VBN
cord-006229-7yoilsho	2366	18	receptor	receptor	NN
cord-006229-7yoilsho	2366	19	kinase	kinase	NN
cord-006229-7yoilsho	2366	20	2	2	CD
cord-006229-7yoilsho	2366	21	(	(	-LRB-
cord-006229-7yoilsho	2366	22	GRK2	GRK2	NNP
cord-006229-7yoilsho	2366	23	)	)	-RRB-
cord-006229-7yoilsho	2366	24	could	could	MD
cord-006229-7yoilsho	2366	25	confer	confer	VB
cord-006229-7yoilsho	2366	26	cardioprotection	cardioprotection	NN
cord-006229-7yoilsho	2366	27	by	by	IN
cord-006229-7yoilsho	2366	28	targeting	target	VBG
cord-006229-7yoilsho	2366	29	the	the	DT
cord-006229-7yoilsho	2366	30	dysfunctional	dysfunctional	JJ
cord-006229-7yoilsho	2366	31	cardiac	cardiac	JJ
cord-006229-7yoilsho	2366	32	substrate	substrate	NN
cord-006229-7yoilsho	2366	33	use	use	NN
cord-006229-7yoilsho	2366	34	.	.	.
cord-006229-7yoilsho	2367	1	The	the	DT
cord-006229-7yoilsho	2367	2	impaired	impaired	JJ
cord-006229-7yoilsho	2367	3	substrate	substrate	NN
cord-006229-7yoilsho	2367	4	metabolism	metabolism	NN
cord-006229-7yoilsho	2367	5	of	of	IN
cord-006229-7yoilsho	2367	6	late	late	JJ
cord-006229-7yoilsho	2367	7	-	-	HYPH
cord-006229-7yoilsho	2367	8	stage	stage	NN
cord-006229-7yoilsho	2367	9	heart	heart	NN
cord-006229-7yoilsho	2367	10	failure	failure	NN
cord-006229-7yoilsho	2367	11	was	be	VBD
cord-006229-7yoilsho	2367	12	reproduced	reproduce	VBN
cord-006229-7yoilsho	2367	13	in	in	IN
cord-006229-7yoilsho	2367	14	a	a	DT
cord-006229-7yoilsho	2367	15	transgenic	transgenic	JJ
cord-006229-7yoilsho	2367	16	model	model	NN
cord-006229-7yoilsho	2367	17	with	with	IN
cord-006229-7yoilsho	2367	18	myocardium	myocardium	NN
cord-006229-7yoilsho	2367	19	-	-	HYPH
cord-006229-7yoilsho	2367	20	specific	specific	JJ
cord-006229-7yoilsho	2367	21	expression	expression	NN
cord-006229-7yoilsho	2367	22	of	of	IN
cord-006229-7yoilsho	2367	23	fatty	fatty	JJ
cord-006229-7yoilsho	2367	24	acid	acid	NN
cord-006229-7yoilsho	2367	25	synthase	synthase	NN
cord-006229-7yoilsho	2367	26	(	(	-LRB-
cord-006229-7yoilsho	2367	27	FASN	FASN	NNP
cord-006229-7yoilsho	2367	28	)	)	-RRB-
cord-006229-7yoilsho	2367	29	,	,	,
cord-006229-7yoilsho	2367	30	which	which	WDT
cord-006229-7yoilsho	2367	31	is	be	VBZ
cord-006229-7yoilsho	2367	32	the	the	DT
cord-006229-7yoilsho	2367	33	major	major	JJ
cord-006229-7yoilsho	2367	34	palmitate	palmitate	NN
cord-006229-7yoilsho	2367	35	-	-	HYPH
cord-006229-7yoilsho	2367	36	synthesizing	synthesize	VBG
cord-006229-7yoilsho	2367	37	enzyme	enzyme	NN
cord-006229-7yoilsho	2367	38	.	.	.
cord-006229-7yoilsho	2368	1	Experiments	experiment	NNS
cord-006229-7yoilsho	2368	2	with	with	IN
cord-006229-7yoilsho	2368	3	a	a	DT
cord-006229-7yoilsho	2368	4	Seahorse	Seahorse	NNP
cord-006229-7yoilsho	2368	5	XF24	XF24	NNP
cord-006229-7yoilsho	2368	6	Extracellular	Extracellular	NNP
cord-006229-7yoilsho	2368	7	Flux	Flux	NNP
cord-006229-7yoilsho	2368	8	Analyzer	Analyzer	NNP
cord-006229-7yoilsho	2368	9	revealed	reveal	VBD
cord-006229-7yoilsho	2368	10	that	that	IN
cord-006229-7yoilsho	2368	11	in	in	IN
cord-006229-7yoilsho	2368	12	an	an	DT
cord-006229-7yoilsho	2368	13	adult	adult	NN
cord-006229-7yoilsho	2368	14	-	-	HYPH
cord-006229-7yoilsho	2368	15	like	like	JJ
cord-006229-7yoilsho	2368	16	lipogenic	lipogenic	JJ
cord-006229-7yoilsho	2368	17	milieu	milieu	NN
cord-006229-7yoilsho	2368	18	,	,	,
cord-006229-7yoilsho	2368	19	FASN	FASN	NNP
cord-006229-7yoilsho	2368	20	-	-	HYPH
cord-006229-7yoilsho	2368	21	transgenic	transgenic	JJ
cord-006229-7yoilsho	2368	22	cardiomyocytes	cardiomyocyte	NNS
cord-006229-7yoilsho	2368	23	reproduced	reproduce	VBD
cord-006229-7yoilsho	2368	24	the	the	DT
cord-006229-7yoilsho	2368	25	overall	overall	JJ
cord-006229-7yoilsho	2368	26	depressed	depressed	JJ
cord-006229-7yoilsho	2368	27	substrate	substrate	NN
cord-006229-7yoilsho	2368	28	use	use	NN
cord-006229-7yoilsho	2368	29	of	of	IN
cord-006229-7yoilsho	2368	30	late	late	JJ
cord-006229-7yoilsho	2368	31	-	-	HYPH
cord-006229-7yoilsho	2368	32	stage	stage	NN
cord-006229-7yoilsho	2368	33	heart	heart	NN
cord-006229-7yoilsho	2368	34	failure	failure	NN
cord-006229-7yoilsho	2368	35	with	with	IN
cord-006229-7yoilsho	2368	36	a	a	DT
cord-006229-7yoilsho	2368	37	switch	switch	NN
cord-006229-7yoilsho	2368	38	from	from	IN
cord-006229-7yoilsho	2368	39	fatty	fatty	JJ
cord-006229-7yoilsho	2368	40	acid	acid	NN
cord-006229-7yoilsho	2368	41	to	to	IN
cord-006229-7yoilsho	2368	42	predominant	predominant	JJ
cord-006229-7yoilsho	2368	43	glucose	glucose	NN
cord-006229-7yoilsho	2368	44	utilization	utilization	NN
cord-006229-7yoilsho	2368	45	.	.	.
cord-006229-7yoilsho	2369	1	The	the	DT
cord-006229-7yoilsho	2369	2	impaired	impaired	JJ
cord-006229-7yoilsho	2369	3	substrate	substrate	NN
cord-006229-7yoilsho	2369	4	use	use	NN
cord-006229-7yoilsho	2369	5	was	be	VBD
cord-006229-7yoilsho	2369	6	largely	largely	RB
cord-006229-7yoilsho	2369	7	retarded	retarded	JJ
cord-006229-7yoilsho	2369	8	by	by	IN
cord-006229-7yoilsho	2369	9	co	co	NN
cord-006229-7yoilsho	2369	10	-	-	NN
cord-006229-7yoilsho	2369	11	expression	expression	NN
cord-006229-7yoilsho	2369	12	of	of	IN
cord-006229-7yoilsho	2369	13	a	a	DT
cord-006229-7yoilsho	2369	14	small	small	JJ
cord-006229-7yoilsho	2369	15	peptide	peptide	JJ
cord-006229-7yoilsho	2369	16	inhibitor	inhibitor	NN
cord-006229-7yoilsho	2369	17	of	of	IN
cord-006229-7yoilsho	2369	18	GRK2	GRK2	NNP
cord-006229-7yoilsho	2369	19	,	,	,
cord-006229-7yoilsho	2369	20	GRKInh	GRKInh	NNP
cord-006229-7yoilsho	2369	21	.	.	.
cord-006229-7yoilsho	2370	1	The	the	DT
cord-006229-7yoilsho	2370	2	GRKInh	GRKInh	NNP
cord-006229-7yoilsho	2370	3	-	-	HYPH
cord-006229-7yoilsho	2370	4	mediated	mediate	VBN
cord-006229-7yoilsho	2370	5	protection	protection	NN
cord-006229-7yoilsho	2370	6	against	against	IN
cord-006229-7yoilsho	2370	7	cardiometabolic	cardiometabolic	JJ
cord-006229-7yoilsho	2370	8	remodelling	remodelling	NN
cord-006229-7yoilsho	2370	9	required	require	VBD
cord-006229-7yoilsho	2370	10	an	an	DT
cord-006229-7yoilsho	2370	11	intact	intact	JJ
cord-006229-7yoilsho	2370	12	RAF	RAF	NNP
cord-006229-7yoilsho	2370	13	-	-	HYPH
cord-006229-7yoilsho	2370	14	ERK1/2	ERK1/2	NNP
cord-006229-7yoilsho	2370	15	axis	axis	NN
cord-006229-7yoilsho	2370	16	and	and	CC
cord-006229-7yoilsho	2370	17	involved	involve	VBD
cord-006229-7yoilsho	2370	18	the	the	DT
cord-006229-7yoilsho	2370	19	ERK1/2-dependent	ERK1/2-dependent	``
cord-006229-7yoilsho	2370	20	inactivation	inactivation	NN
cord-006229-7yoilsho	2370	21	of	of	IN
cord-006229-7yoilsho	2370	22	the	the	DT
cord-006229-7yoilsho	2370	23	heart	heart	NN
cord-006229-7yoilsho	2370	24	failure	failure	NN
cord-006229-7yoilsho	2370	25	-	-	HYPH
cord-006229-7yoilsho	2370	26	promoting	promote	VBG
cord-006229-7yoilsho	2370	27	peroxisome	peroxisome	NN
cord-006229-7yoilsho	2370	28	proliferatoractivated	proliferatoractivated	JJ
cord-006229-7yoilsho	2370	29	receptor	receptor	NN
cord-006229-7yoilsho	2370	30	gamma	gamma	NN
cord-006229-7yoilsho	2370	31	(	(	-LRB-
cord-006229-7yoilsho	2370	32	Pparg	Pparg	NNP
cord-006229-7yoilsho	2370	33	)	)	-RRB-
cord-006229-7yoilsho	2370	34	by	by	IN
cord-006229-7yoilsho	2370	35	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	2370	36	of	of	IN
cord-006229-7yoilsho	2370	37	serine-273	serine-273	ADD
cord-006229-7yoilsho	2370	38	.	.	.
cord-006229-7yoilsho	2371	1	As	as	IN
cord-006229-7yoilsho	2371	2	a	a	DT
cord-006229-7yoilsho	2371	3	consequence	consequence	NN
cord-006229-7yoilsho	2371	4	of	of	IN
cord-006229-7yoilsho	2371	5	ERK	ERK	NNP
cord-006229-7yoilsho	2371	6	-	-	HYPH
cord-006229-7yoilsho	2371	7	dependent	dependent	JJ
cord-006229-7yoilsho	2371	8	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	2371	9	of	of	IN
cord-006229-7yoilsho	2371	10	Pparg	Pparg	NNP
cord-006229-7yoilsho	2371	11	on	on	IN
cord-006229-7yoilsho	2371	12	serine-273	serine-273	ADD
cord-006229-7yoilsho	2371	13	,	,	,
cord-006229-7yoilsho	2371	14	the	the	DT
cord-006229-7yoilsho	2371	15	expression	expression	NN
cord-006229-7yoilsho	2371	16	of	of	IN
cord-006229-7yoilsho	2371	17	heart	heart	NN
cord-006229-7yoilsho	2371	18	failure	failure	NN
cord-006229-7yoilsho	2371	19	-	-	HYPH
cord-006229-7yoilsho	2371	20	related	relate	VBN
cord-006229-7yoilsho	2371	21	Pparg	Pparg	NNP
cord-006229-7yoilsho	2371	22	targets	target	NNS
cord-006229-7yoilsho	2371	23	such	such	JJ
cord-006229-7yoilsho	2371	24	as	as	IN
cord-006229-7yoilsho	2371	25	fatty	fatty	JJ
cord-006229-7yoilsho	2371	26	acid	acid	NN
cord-006229-7yoilsho	2371	27	synthase	synthase	NN
cord-006229-7yoilsho	2371	28	,	,	,
cord-006229-7yoilsho	2371	29	resistin	resistin	NN
cord-006229-7yoilsho	2371	30	and	and	CC
cord-006229-7yoilsho	2371	31	adiponectin	adiponectin	NN
cord-006229-7yoilsho	2371	32	was	be	VBD
cord-006229-7yoilsho	2371	33	decreased	decrease	VBN
cord-006229-7yoilsho	2371	34	.	.	.
cord-006229-7yoilsho	2372	1	The	the	DT
cord-006229-7yoilsho	2372	2	importance	importance	NN
cord-006229-7yoilsho	2372	3	of	of	IN
cord-006229-7yoilsho	2372	4	Pparg	Pparg	NNP
cord-006229-7yoilsho	2372	5	serine-273	serine-273	NNP
cord-006229-7yoilsho	2372	6	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	2372	7	was	be	VBD
cord-006229-7yoilsho	2372	8	further	further	RB
cord-006229-7yoilsho	2372	9	shown	show	VBN
cord-006229-7yoilsho	2372	10	in	in	IN
cord-006229-7yoilsho	2372	11	transgenic	transgenic	JJ
cord-006229-7yoilsho	2372	12	mice	mouse	NNS
cord-006229-7yoilsho	2372	13	with	with	IN
cord-006229-7yoilsho	2372	14	myocardium	myocardium	NN
cord-006229-7yoilsho	2372	15	-	-	HYPH
cord-006229-7yoilsho	2372	16	specific	specific	JJ
cord-006229-7yoilsho	2372	17	expression	expression	NN
cord-006229-7yoilsho	2372	18	of	of	IN
cord-006229-7yoilsho	2372	19	the	the	DT
cord-006229-7yoilsho	2372	20	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	2372	21	-	-	HYPH
cord-006229-7yoilsho	2372	22	deficient	deficient	JJ
cord-006229-7yoilsho	2372	23	PPARG	PPARG	NNP
cord-006229-7yoilsho	2372	24	serine-273A	serine-273A	NNP
cord-006229-7yoilsho	2372	25	mutant	mutant	NN
cord-006229-7yoilsho	2372	26	,	,	,
cord-006229-7yoilsho	2372	27	which	which	WDT
cord-006229-7yoilsho	2372	28	was	be	VBD
cord-006229-7yoilsho	2372	29	resistant	resistant	JJ
cord-006229-7yoilsho	2372	30	to	to	IN
cord-006229-7yoilsho	2372	31	the	the	DT
cord-006229-7yoilsho	2372	32	cardioprotective	cardioprotective	JJ
cord-006229-7yoilsho	2372	33	activity	activity	NN
cord-006229-7yoilsho	2372	34	of	of	IN
cord-006229-7yoilsho	2372	35	GRKInh	GRKInh	NNP
cord-006229-7yoilsho	2372	36	.	.	.
cord-006229-7yoilsho	2373	1	Taken	take	VBN
cord-006229-7yoilsho	2373	2	together	together	RB
cord-006229-7yoilsho	2373	3	our	-PRON-	PRP$
cord-006229-7yoilsho	2373	4	experiments	experiment	NNS
cord-006229-7yoilsho	2373	5	show	show	VBP
cord-006229-7yoilsho	2373	6	that	that	IN
cord-006229-7yoilsho	2373	7	GRK2	GRK2	NNP
cord-006229-7yoilsho	2373	8	inhibition	inhibition	NN
cord-006229-7yoilsho	2373	9	could	could	MD
cord-006229-7yoilsho	2373	10	target	target	VB
cord-006229-7yoilsho	2373	11	cardiometabolic	cardiometabolic	JJ
cord-006229-7yoilsho	2373	12	remodelling	remodelling	NN
cord-006229-7yoilsho	2373	13	by	by	IN
cord-006229-7yoilsho	2373	14	inhibition	inhibition	NN
cord-006229-7yoilsho	2373	15	of	of	IN
cord-006229-7yoilsho	2373	16	the	the	DT
cord-006229-7yoilsho	2373	17	heart	heart	NN
cord-006229-7yoilsho	2373	18	failure	failure	NN
cord-006229-7yoilsho	2373	19	-	-	HYPH
cord-006229-7yoilsho	2373	20	promoting	promote	VBG
cord-006229-7yoilsho	2373	21	transcription	transcription	NN
cord-006229-7yoilsho	2373	22	factor	factor	NN
cord-006229-7yoilsho	2373	23	Pparg	Pparg	NNP
cord-006229-7yoilsho	2373	24	.	.	.
cord-006229-7yoilsho	2374	1	The	the	DT
cord-006229-7yoilsho	2374	2	effect	effect	NN
cord-006229-7yoilsho	2374	3	of	of	IN
cord-006229-7yoilsho	2374	4	sodium	sodium	NN
cord-006229-7yoilsho	2374	5	valproate	valproate	RB
cord-006229-7yoilsho	2374	6	on	on	IN
cord-006229-7yoilsho	2374	7	the	the	DT
cord-006229-7yoilsho	2374	8	action	action	NN
cord-006229-7yoilsho	2374	9	potential	potential	NN
cord-006229-7yoilsho	2374	10	of	of	IN
cord-006229-7yoilsho	2374	11	atrial	atrial	JJ
cord-006229-7yoilsho	2374	12	myocytes	myocyte	NNS
cord-006229-7yoilsho	2374	13	of	of	IN
cord-006229-7yoilsho	2374	14	CREM	CREM	NNP
cord-006229-7yoilsho	2374	15	Ib∆C	Ib∆C	NNP
cord-006229-7yoilsho	2374	16	-	-	HYPH
cord-006229-7yoilsho	2374	17	X	x	NN
cord-006229-7yoilsho	2374	18	transgenic	transgenic	JJ
cord-006229-7yoilsho	2374	19	mice	mouse	NNS
cord-006229-7yoilsho	2375	1	Introduction	introduction	NN
cord-006229-7yoilsho	2375	2	:	:	:
cord-006229-7yoilsho	2376	1	In	in	IN
cord-006229-7yoilsho	2376	2	mouse	mouse	NN
cord-006229-7yoilsho	2376	3	,	,	,
cord-006229-7yoilsho	2376	4	cardiomyocyte	cardiomyocyte	NNP
cord-006229-7yoilsho	2376	5	directed	direct	VBD
cord-006229-7yoilsho	2376	6	over	over	IN
cord-006229-7yoilsho	2376	7	-	-	HYPH
cord-006229-7yoilsho	2376	8	expression	expression	NN
cord-006229-7yoilsho	2376	9	of	of	IN
cord-006229-7yoilsho	2376	10	transcription	transcription	NN
cord-006229-7yoilsho	2376	11	factor	factor	NN
cord-006229-7yoilsho	2376	12	CREM	CREM	NNP
cord-006229-7yoilsho	2376	13	(	(	-LRB-
cord-006229-7yoilsho	2376	14	cAMP	camp	NN
cord-006229-7yoilsho	2376	15	response	response	NN
cord-006229-7yoilsho	2376	16	element	element	NN
cord-006229-7yoilsho	2376	17	modulator	modulator	NN
cord-006229-7yoilsho	2376	18	)	)	-RRB-
cord-006229-7yoilsho	2376	19	causes	cause	VBZ
cord-006229-7yoilsho	2376	20	an	an	DT
cord-006229-7yoilsho	2376	21	atrial	atrial	JJ
cord-006229-7yoilsho	2376	22	phenotype	phenotype	NN
cord-006229-7yoilsho	2376	23	characterized	characterize	VBN
cord-006229-7yoilsho	2376	24	by	by	IN
cord-006229-7yoilsho	2376	25	hypertrophy	hypertrophy	NN
cord-006229-7yoilsho	2376	26	,	,	,
cord-006229-7yoilsho	2376	27	reduced	reduce	VBN
cord-006229-7yoilsho	2376	28	contractility	contractility	NN
cord-006229-7yoilsho	2376	29	and	and	CC
cord-006229-7yoilsho	2376	30	increased	increase	VBN
cord-006229-7yoilsho	2376	31	duration	duration	NN
cord-006229-7yoilsho	2376	32	of	of	IN
cord-006229-7yoilsho	2376	33	the	the	DT
cord-006229-7yoilsho	2376	34	monophasic	monophasic	JJ
cord-006229-7yoilsho	2376	35	action	action	NN
cord-006229-7yoilsho	2376	36	potential	potential	NN
cord-006229-7yoilsho	2376	37	(	(	-LRB-
cord-006229-7yoilsho	2376	38	MAP	MAP	NNP
cord-006229-7yoilsho	2376	39	)	)	-RRB-
cord-006229-7yoilsho	2376	40	.	.	.
cord-006229-7yoilsho	2377	1	Moreover	moreover	RB
cord-006229-7yoilsho	2377	2	,	,	,
cord-006229-7yoilsho	2377	3	this	this	DT
cord-006229-7yoilsho	2377	4	animal	animal	NN
cord-006229-7yoilsho	2377	5	model	model	NN
cord-006229-7yoilsho	2377	6	(	(	-LRB-
cord-006229-7yoilsho	2377	7	CREM	CREM	NNP
cord-006229-7yoilsho	2377	8	Ib∆C	Ib∆C	NNP
cord-006229-7yoilsho	2377	9	-	-	HYPH
cord-006229-7yoilsho	2377	10	X	X	NNP
cord-006229-7yoilsho	2377	11	)	)	-RRB-
cord-006229-7yoilsho	2377	12	showed	show	VBD
cord-006229-7yoilsho	2377	13	spontaneous	spontaneous	JJ
cord-006229-7yoilsho	2377	14	atrial	atrial	JJ
cord-006229-7yoilsho	2377	15	fibrillation	fibrillation	NN
cord-006229-7yoilsho	2377	16	(	(	-LRB-
cord-006229-7yoilsho	2377	17	AF	AF	NNP
cord-006229-7yoilsho	2377	18	)	)	-RRB-
cord-006229-7yoilsho	2377	19	episodes	episode	NNS
cord-006229-7yoilsho	2377	20	as	as	RB
cord-006229-7yoilsho	2377	21	early	early	RB
cord-006229-7yoilsho	2377	22	as	as	IN
cord-006229-7yoilsho	2377	23	5	5	CD
cord-006229-7yoilsho	2377	24	weeks	week	NNS
cord-006229-7yoilsho	2377	25	of	of	IN
cord-006229-7yoilsho	2377	26	age	age	NN
cord-006229-7yoilsho	2377	27	in	in	IN
cord-006229-7yoilsho	2377	28	homozygous	homozygous	JJ
cord-006229-7yoilsho	2377	29	mice	mouse	NNS
cord-006229-7yoilsho	2377	30	and	and	CC
cord-006229-7yoilsho	2377	31	10	10	CD
cord-006229-7yoilsho	2377	32	-	-	SYM
cord-006229-7yoilsho	2377	33	12	12	CD
cord-006229-7yoilsho	2377	34	weeks	week	NNS
cord-006229-7yoilsho	2377	35	of	of	IN
cord-006229-7yoilsho	2377	36	age	age	NN
cord-006229-7yoilsho	2377	37	in	in	IN
cord-006229-7yoilsho	2377	38	heterozygous	heterozygous	JJ
cord-006229-7yoilsho	2377	39	mice	mouse	NNS
cord-006229-7yoilsho	2377	40	(	(	-LRB-
cord-006229-7yoilsho	2377	41	phenotype	phenotype	NN
cord-006229-7yoilsho	2377	42	delayed	delay	VBN
cord-006229-7yoilsho	2377	43	towards	towards	IN
cord-006229-7yoilsho	2377	44	adult	adult	NN
cord-006229-7yoilsho	2377	45	stage	stage	NN
cord-006229-7yoilsho	2377	46	)	)	-RRB-
cord-006229-7yoilsho	2377	47	.	.	.
cord-006229-7yoilsho	2378	1	Previous	previous	JJ
cord-006229-7yoilsho	2378	2	studies	study	NNS
cord-006229-7yoilsho	2378	3	in	in	IN
cord-006229-7yoilsho	2378	4	heterozygous	heterozygous	JJ
cord-006229-7yoilsho	2378	5	mice	mouse	NNS
cord-006229-7yoilsho	2378	6	targeted	target	VBD
cord-006229-7yoilsho	2378	7	HDAC2	hdac2	NN
cord-006229-7yoilsho	2378	8	inhibition	inhibition	NN
cord-006229-7yoilsho	2378	9	by	by	IN
cord-006229-7yoilsho	2378	10	sodium	sodium	NN
cord-006229-7yoilsho	2378	11	valproate	valproate	RB
cord-006229-7yoilsho	2378	12	(	(	-LRB-
cord-006229-7yoilsho	2378	13	VPA	VPA	NNP
cord-006229-7yoilsho	2378	14	,	,	,
cord-006229-7yoilsho	2378	15	an	an	DT
cord-006229-7yoilsho	2378	16	anticonvulsant	anticonvulsant	JJ
cord-006229-7yoilsho	2378	17	drug	drug	NN
cord-006229-7yoilsho	2378	18	,	,	,
cord-006229-7yoilsho	2378	19	acting	act	VBG
cord-006229-7yoilsho	2378	20	also	also	RB
cord-006229-7yoilsho	2378	21	as	as	IN
cord-006229-7yoilsho	2378	22	inhibitor	inhibitor	NN
cord-006229-7yoilsho	2378	23	of	of	IN
cord-006229-7yoilsho	2378	24	HDAC	HDAC	NNP
cord-006229-7yoilsho	2378	25	class	class	NN
cord-006229-7yoilsho	2379	1	I	-PRON-	PRP
cord-006229-7yoilsho	2379	2	>	>	XX
cord-006229-7yoilsho	2379	3	II	II	NNP
cord-006229-7yoilsho	2379	4	)	)	-RRB-
cord-006229-7yoilsho	2379	5	.	.	.
cord-006229-7yoilsho	2380	1	VPA	VPA	NNP
cord-006229-7yoilsho	2380	2	treatment	treatment	NN
cord-006229-7yoilsho	2380	3	delayed	delay	VBD
cord-006229-7yoilsho	2380	4	significantly	significantly	RB
cord-006229-7yoilsho	2380	5	the	the	DT
cord-006229-7yoilsho	2380	6	development	development	NN
cord-006229-7yoilsho	2380	7	of	of	IN
cord-006229-7yoilsho	2380	8	atrial	atrial	JJ
cord-006229-7yoilsho	2380	9	hypertrophy	hypertrophy	NN
cord-006229-7yoilsho	2380	10	and	and	CC
cord-006229-7yoilsho	2380	11	the	the	DT
cord-006229-7yoilsho	2380	12	incidence	incidence	NN
cord-006229-7yoilsho	2380	13	of	of	IN
cord-006229-7yoilsho	2380	14	AF	AF	NNP
cord-006229-7yoilsho	2380	15	episodes	episode	NNS
cord-006229-7yoilsho	2380	16	,	,	,
cord-006229-7yoilsho	2380	17	without	without	IN
cord-006229-7yoilsho	2380	18	affecting	affect	VBG
cord-006229-7yoilsho	2380	19	cellular	cellular	JJ
cord-006229-7yoilsho	2380	20	hypertrophy	hypertrophy	NN
cord-006229-7yoilsho	2380	21	.	.	.
cord-006229-7yoilsho	2381	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	2381	2	aim	aim	NN
cord-006229-7yoilsho	2381	3	was	be	VBD
cord-006229-7yoilsho	2381	4	to	to	TO
cord-006229-7yoilsho	2381	5	investigate	investigate	VB
cord-006229-7yoilsho	2381	6	the	the	DT
cord-006229-7yoilsho	2381	7	effect	effect	NN
cord-006229-7yoilsho	2381	8	of	of	IN
cord-006229-7yoilsho	2381	9	chronic	chronic	JJ
cord-006229-7yoilsho	2381	10	VPA	VPA	NNP
cord-006229-7yoilsho	2381	11	treatment	treatment	NN
cord-006229-7yoilsho	2381	12	on	on	IN
cord-006229-7yoilsho	2381	13	the	the	DT
cord-006229-7yoilsho	2381	14	electrical	electrical	JJ
cord-006229-7yoilsho	2381	15	activity	activity	NN
cord-006229-7yoilsho	2381	16	of	of	IN
cord-006229-7yoilsho	2381	17	atrial	atrial	JJ
cord-006229-7yoilsho	2381	18	myocytes	myocyte	NNS
cord-006229-7yoilsho	2381	19	isolated	isolate	VBN
cord-006229-7yoilsho	2381	20	from	from	IN
cord-006229-7yoilsho	2381	21	CREM	CREM	NNP
cord-006229-7yoilsho	2382	1	Ib∆C	Ib∆C	NNP
cord-006229-7yoilsho	2382	2	-	-	HYPH
cord-006229-7yoilsho	2382	3	X	x	NN
cord-006229-7yoilsho	2382	4	and	and	CC
cord-006229-7yoilsho	2382	5	wild	wild	JJ
cord-006229-7yoilsho	2382	6	type	type	NN
cord-006229-7yoilsho	2382	7	(	(	-LRB-
cord-006229-7yoilsho	2382	8	WT	WT	NNP
cord-006229-7yoilsho	2382	9	)	)	-RRB-
cord-006229-7yoilsho	2382	10	littermate	littermate	NN
cord-006229-7yoilsho	2382	11	mice	mouse	NNS
cord-006229-7yoilsho	2382	12	.	.	.
cord-006229-7yoilsho	2383	1	Methods	method	NNS
cord-006229-7yoilsho	2383	2	and	and	CC
cord-006229-7yoilsho	2383	3	Results	result	NNS
cord-006229-7yoilsho	2383	4	:	:	:
cord-006229-7yoilsho	2383	5	Atrial	atrial	JJ
cord-006229-7yoilsho	2383	6	myocytes	myocyte	NNS
cord-006229-7yoilsho	2383	7	were	be	VBD
cord-006229-7yoilsho	2383	8	isolated	isolate	VBN
cord-006229-7yoilsho	2383	9	from	from	IN
cord-006229-7yoilsho	2383	10	12	12	CD
cord-006229-7yoilsho	2383	11	weeks	week	NNS
cord-006229-7yoilsho	2383	12	old	old	JJ
cord-006229-7yoilsho	2383	13	wild	wild	JJ
cord-006229-7yoilsho	2383	14	type	type	NN
cord-006229-7yoilsho	2383	15	mice	mouse	NNS
cord-006229-7yoilsho	2383	16	(	(	-LRB-
cord-006229-7yoilsho	2383	17	WT	WT	NNP
cord-006229-7yoilsho	2383	18	)	)	-RRB-
cord-006229-7yoilsho	2383	19	and	and	CC
cord-006229-7yoilsho	2383	20	heterozygous	heterozygous	JJ
cord-006229-7yoilsho	2383	21	CREM	CREM	NNP
cord-006229-7yoilsho	2384	1	Ib∆C	Ib∆C	NNP
cord-006229-7yoilsho	2384	2	-	-	HYPH
cord-006229-7yoilsho	2384	3	X	x	NN
cord-006229-7yoilsho	2384	4	transgenic	transgenic	JJ
cord-006229-7yoilsho	2384	5	mice	mouse	NNS
cord-006229-7yoilsho	2384	6	with	with	IN
cord-006229-7yoilsho	2384	7	enlarged	enlarged	JJ
cord-006229-7yoilsho	2384	8	atria	atria	NN
cord-006229-7yoilsho	2384	9	(	(	-LRB-
cord-006229-7yoilsho	2384	10	TG	TG	NNP
cord-006229-7yoilsho	2384	11	)	)	-RRB-
cord-006229-7yoilsho	2384	12	,	,	,
cord-006229-7yoilsho	2384	13	treated	treat	VBN
cord-006229-7yoilsho	2384	14	for	for	IN
cord-006229-7yoilsho	2384	15	7	7	CD
cord-006229-7yoilsho	2384	16	weeks	week	NNS
cord-006229-7yoilsho	2384	17	with	with	IN
cord-006229-7yoilsho	2384	18	VPA	VPA	NNP
cord-006229-7yoilsho	2384	19	(	(	-LRB-
cord-006229-7yoilsho	2384	20	0.4	0.4	CD
cord-006229-7yoilsho	2384	21	mM	mm	CD
cord-006229-7yoilsho	2384	22	in	in	IN
cord-006229-7yoilsho	2384	23	the	the	DT
cord-006229-7yoilsho	2384	24	drinking	drinking	NN
cord-006229-7yoilsho	2384	25	water	water	NN
cord-006229-7yoilsho	2384	26	)	)	-RRB-
cord-006229-7yoilsho	2384	27	vs.	vs.	CC
cord-006229-7yoilsho	2384	28	water	water	NN
cord-006229-7yoilsho	2384	29	(	(	-LRB-
cord-006229-7yoilsho	2384	30	vehicle	vehicle	NN
cord-006229-7yoilsho	2384	31	control	control	NN
cord-006229-7yoilsho	2384	32	)	)	-RRB-
cord-006229-7yoilsho	2384	33	.	.	.
cord-006229-7yoilsho	2385	1	Action	action	NN
cord-006229-7yoilsho	2385	2	potentials	potential	NNS
cord-006229-7yoilsho	2385	3	(	(	-LRB-
cord-006229-7yoilsho	2385	4	AP	AP	NNP
cord-006229-7yoilsho	2385	5	)	)	-RRB-
cord-006229-7yoilsho	2385	6	were	be	VBD
cord-006229-7yoilsho	2385	7	measured	measure	VBN
cord-006229-7yoilsho	2385	8	at	at	IN
cord-006229-7yoilsho	2385	9	room	room	NN
cord-006229-7yoilsho	2385	10	temperature	temperature	NN
cord-006229-7yoilsho	2385	11	using	use	VBG
cord-006229-7yoilsho	2385	12	the	the	DT
cord-006229-7yoilsho	2385	13	patch	patch	NN
cord-006229-7yoilsho	2385	14	-	-	HYPH
cord-006229-7yoilsho	2385	15	clamp	clamp	NN
cord-006229-7yoilsho	2385	16	technique	technique	NN
cord-006229-7yoilsho	2385	17	.	.	.
cord-006229-7yoilsho	2386	1	Atrial	atrial	JJ
cord-006229-7yoilsho	2386	2	myocytes	myocyte	NNS
cord-006229-7yoilsho	2386	3	of	of	IN
cord-006229-7yoilsho	2386	4	water	water	NN
cord-006229-7yoilsho	2386	5	treated	treat	VBN
cord-006229-7yoilsho	2386	6	TG	TG	NNP
cord-006229-7yoilsho	2386	7	mice	mouse	NNS
cord-006229-7yoilsho	2386	8	had	have	VBD
cord-006229-7yoilsho	2386	9	the	the	DT
cord-006229-7yoilsho	2386	10	AP	AP	NNP
cord-006229-7yoilsho	2386	11	amplitude	amplitude	NN
cord-006229-7yoilsho	2386	12	significantly	significantly	RB
cord-006229-7yoilsho	2386	13	reduced	reduce	VBN
cord-006229-7yoilsho	2386	14	by	by	IN
cord-006229-7yoilsho	2386	15	7	7	CD
cord-006229-7yoilsho	2386	16	mV	mv	NN
cord-006229-7yoilsho	2386	17	compared	compare	VBN
cord-006229-7yoilsho	2386	18	to	to	IN
cord-006229-7yoilsho	2386	19	water	water	NN
cord-006229-7yoilsho	2386	20	treated	treat	VBN
cord-006229-7yoilsho	2386	21	WT	WT	NNP
cord-006229-7yoilsho	2386	22	,	,	,
cord-006229-7yoilsho	2386	23	and	and	CC
cord-006229-7yoilsho	2386	24	,	,	,
cord-006229-7yoilsho	2386	25	in	in	IN
cord-006229-7yoilsho	2386	26	line	line	NN
cord-006229-7yoilsho	2386	27	with	with	IN
cord-006229-7yoilsho	2386	28	previous	previous	JJ
cord-006229-7yoilsho	2386	29	results	result	NNS
cord-006229-7yoilsho	2386	30	for	for	IN
cord-006229-7yoilsho	2386	31	the	the	DT
cord-006229-7yoilsho	2386	32	MAP	MAP	NNP
cord-006229-7yoilsho	2386	33	,	,	,
cord-006229-7yoilsho	2386	34	the	the	DT
cord-006229-7yoilsho	2386	35	TG	TG	NNP
cord-006229-7yoilsho	2386	36	cells	cell	NNS
cord-006229-7yoilsho	2386	37	depolarized	depolarize	VBN
cord-006229-7yoilsho	2386	38	with	with	IN
cord-006229-7yoilsho	2386	39	a	a	DT
cord-006229-7yoilsho	2386	40	slower	slow	JJR
cord-006229-7yoilsho	2386	41	slope	slope	NN
cord-006229-7yoilsho	2386	42	of	of	IN
cord-006229-7yoilsho	2386	43	90.2±8	90.2±8	CD
cord-006229-7yoilsho	2386	44	V	v	NN
cord-006229-7yoilsho	2386	45	/	/	SYM
cord-006229-7yoilsho	2386	46	s	s	NN
cord-006229-7yoilsho	2386	47	(	(	-LRB-
cord-006229-7yoilsho	2386	48	TG	TG	NNP
cord-006229-7yoilsho	2386	49	:	:	:
cord-006229-7yoilsho	2386	50	n=33	n=33	NN
cord-006229-7yoilsho	2386	51	cells	cell	NNS
cord-006229-7yoilsho	2386	52	)	)	-RRB-
cord-006229-7yoilsho	2386	53	vs.	vs.	FW
cord-006229-7yoilsho	2386	54	109.8±5.1	109.8±5.1	NNP
cord-006229-7yoilsho	2387	1	V	V	NNP
cord-006229-7yoilsho	2387	2	/	/	SYM
cord-006229-7yoilsho	2387	3	s	s	NN
cord-006229-7yoilsho	2387	4	(	(	-LRB-
cord-006229-7yoilsho	2387	5	WT	WT	NNP
cord-006229-7yoilsho	2387	6	:	:	:
cord-006229-7yoilsho	2388	1	n=30	n=30	NNP
cord-006229-7yoilsho	2388	2	,	,	,
cord-006229-7yoilsho	2388	3	p=0.05	p=0.05	NNP
cord-006229-7yoilsho	2388	4	)	)	-RRB-
cord-006229-7yoilsho	2388	5	.	.	.
cord-006229-7yoilsho	2389	1	Moreover	moreover	RB
cord-006229-7yoilsho	2389	2	,	,	,
cord-006229-7yoilsho	2389	3	AP	AP	NNP
cord-006229-7yoilsho	2389	4	of	of	IN
cord-006229-7yoilsho	2389	5	atrial	atrial	JJ
cord-006229-7yoilsho	2389	6	myocytes	myocyte	NNS
cord-006229-7yoilsho	2389	7	isolated	isolate	VBN
cord-006229-7yoilsho	2389	8	from	from	IN
cord-006229-7yoilsho	2389	9	water	water	NN
cord-006229-7yoilsho	2389	10	treated	treat	VBN
cord-006229-7yoilsho	2389	11	TG	TG	NNP
cord-006229-7yoilsho	2389	12	mice	mouse	NNS
cord-006229-7yoilsho	2389	13	had	have	VBD
cord-006229-7yoilsho	2389	14	longer	long	JJR
cord-006229-7yoilsho	2389	15	duration	duration	NN
cord-006229-7yoilsho	2389	16	(	(	-LRB-
cord-006229-7yoilsho	2389	17	APD	APD	NNP
cord-006229-7yoilsho	2389	18	)	)	-RRB-
cord-006229-7yoilsho	2389	19	at	at	IN
cord-006229-7yoilsho	2389	20	50	50	CD
cord-006229-7yoilsho	2389	21	%	%	NN
cord-006229-7yoilsho	2390	1	(	(	-LRB-
cord-006229-7yoilsho	2390	2	TG	TG	NNP
cord-006229-7yoilsho	2390	3	:	:	:
cord-006229-7yoilsho	2391	1	11.6±1.4	11.6±1.4	NNP
cord-006229-7yoilsho	2391	2	ms	ms	NNP
cord-006229-7yoilsho	2391	3	,	,	,
cord-006229-7yoilsho	2391	4	n=35	n=35	NNP
cord-006229-7yoilsho	2391	5	vs.	vs.	IN
cord-006229-7yoilsho	2391	6	WT	WT	NNP
cord-006229-7yoilsho	2391	7	:	:	:
cord-006229-7yoilsho	2392	1	6.9±0.5	6.9±0.5	NNP
cord-006229-7yoilsho	2392	2	ms	ms	NNP
cord-006229-7yoilsho	2392	3	,	,	,
cord-006229-7yoilsho	2392	4	n=30	n=30	NNP
cord-006229-7yoilsho	2392	5	,	,	,
cord-006229-7yoilsho	2392	6	p<0.01	p<0.01	NNP
cord-006229-7yoilsho	2392	7	)	)	-RRB-
cord-006229-7yoilsho	2392	8	,	,	,
cord-006229-7yoilsho	2392	9	at	at	IN
cord-006229-7yoilsho	2392	10	70	70	CD
cord-006229-7yoilsho	2392	11	%	%	NN
cord-006229-7yoilsho	2392	12	(	(	-LRB-
cord-006229-7yoilsho	2392	13	in	in	IN
cord-006229-7yoilsho	2392	14	ms	ms	NNP
cord-006229-7yoilsho	2392	15	:	:	:
cord-006229-7yoilsho	2392	16	21.2±2.5	21.2±2.5	CD
cord-006229-7yoilsho	2392	17	vs.	vs.	IN
cord-006229-7yoilsho	2392	18	13.6±1	13.6±1	CD
cord-006229-7yoilsho	2392	19	,	,	,
cord-006229-7yoilsho	2392	20	p<0.05	p<0.05	CD
cord-006229-7yoilsho	2392	21	)	)	-RRB-
cord-006229-7yoilsho	2393	1	and	and	CC
cord-006229-7yoilsho	2393	2	at	at	IN
cord-006229-7yoilsho	2393	3	90	90	CD
cord-006229-7yoilsho	2393	4	%	%	NN
cord-006229-7yoilsho	2393	5	(	(	-LRB-
cord-006229-7yoilsho	2393	6	in	in	IN
cord-006229-7yoilsho	2393	7	ms	ms	NNP
cord-006229-7yoilsho	2393	8	:	:	:
cord-006229-7yoilsho	2393	9	46.8±4.5	46.8±4.5	CD
cord-006229-7yoilsho	2393	10	vs.	vs.	IN
cord-006229-7yoilsho	2393	11	34±2.5	34±2.5	CD
cord-006229-7yoilsho	2393	12	,	,	,
cord-006229-7yoilsho	2393	13	p<0.05	p<0.05	CD
cord-006229-7yoilsho	2393	14	)	)	-RRB-
cord-006229-7yoilsho	2393	15	repolarization	repolarization	NN
cord-006229-7yoilsho	2393	16	.	.	.
cord-006229-7yoilsho	2394	1	VPA	VPA	NNP
cord-006229-7yoilsho	2394	2	treatment	treatment	NN
cord-006229-7yoilsho	2394	3	reduced	reduce	VBD
cord-006229-7yoilsho	2394	4	AP	AP	NNP
cord-006229-7yoilsho	2394	5	amplitude	amplitude	NN
cord-006229-7yoilsho	2394	6	in	in	IN
cord-006229-7yoilsho	2394	7	WT	WT	NNP
cord-006229-7yoilsho	2394	8	mice	mouse	NNS
cord-006229-7yoilsho	2394	9	by	by	IN
cord-006229-7yoilsho	2394	10	6	6	CD
cord-006229-7yoilsho	2394	11	mV	mV	NNP
cord-006229-7yoilsho	2394	12	(	(	-LRB-
cord-006229-7yoilsho	2394	13	n=22	n=22	NNP
cord-006229-7yoilsho	2394	14	,	,	,
cord-006229-7yoilsho	2394	15	p<0.05	p<0.05	CD
cord-006229-7yoilsho	2394	16	)	)	-RRB-
cord-006229-7yoilsho	2394	17	vs.	vs.	CC
cord-006229-7yoilsho	2394	18	water	water	NN
cord-006229-7yoilsho	2394	19	treated	treat	VBN
cord-006229-7yoilsho	2394	20	WT	WT	NNP
cord-006229-7yoilsho	2394	21	,	,	,
cord-006229-7yoilsho	2394	22	without	without	IN
cord-006229-7yoilsho	2394	23	altering	alter	VBG
cord-006229-7yoilsho	2394	24	the	the	DT
cord-006229-7yoilsho	2394	25	slope	slope	NN
cord-006229-7yoilsho	2394	26	of	of	IN
cord-006229-7yoilsho	2394	27	depolarization	depolarization	NN
cord-006229-7yoilsho	2394	28	or	or	CC
cord-006229-7yoilsho	2394	29	the	the	DT
cord-006229-7yoilsho	2394	30	APD	APD	NNP
cord-006229-7yoilsho	2394	31	.	.	.
cord-006229-7yoilsho	2395	1	In	in	IN
cord-006229-7yoilsho	2395	2	VPA	VPA	NNP
cord-006229-7yoilsho	2395	3	treated	treat	VBD
cord-006229-7yoilsho	2395	4	TG	TG	NNP
cord-006229-7yoilsho	2395	5	mice	mouse	NNS
cord-006229-7yoilsho	2395	6	the	the	DT
cord-006229-7yoilsho	2395	7	APD	APD	NNP
cord-006229-7yoilsho	2395	8	was	be	VBD
cord-006229-7yoilsho	2395	9	reduced	reduce	VBN
cord-006229-7yoilsho	2395	10	(	(	-LRB-
cord-006229-7yoilsho	2395	11	50	50	CD
cord-006229-7yoilsho	2395	12	%	%	NN
cord-006229-7yoilsho	2395	13	:	:	:
cord-006229-7yoilsho	2395	14	7.3±0.8	7.3±0.8	NNP
cord-006229-7yoilsho	2395	15	ms	ms	NNP
cord-006229-7yoilsho	2395	16	,	,	,
cord-006229-7yoilsho	2395	17	70	70	CD
cord-006229-7yoilsho	2395	18	%	%	NN
cord-006229-7yoilsho	2395	19	:	:	:
cord-006229-7yoilsho	2395	20	13.8±1.5	13.8±1.5	CD
cord-006229-7yoilsho	2395	21	ms	ms	NNP
cord-006229-7yoilsho	2395	22	,	,	,
cord-006229-7yoilsho	2395	23	90	90	CD
cord-006229-7yoilsho	2395	24	%	%	NN
cord-006229-7yoilsho	2395	25	:	:	:
cord-006229-7yoilsho	2395	26	30.9±3.2	30.9±3.2	CD
cord-006229-7yoilsho	2395	27	ms	ms	NNP
cord-006229-7yoilsho	2395	28	,	,	,
cord-006229-7yoilsho	2395	29	n=21	n=21	NNP
cord-006229-7yoilsho	2395	30	,	,	,
cord-006229-7yoilsho	2395	31	p<0.05	p<0.05	JJ
cord-006229-7yoilsho	2395	32	vs.	vs.	IN
cord-006229-7yoilsho	2395	33	untreated	untreated	JJ
cord-006229-7yoilsho	2395	34	TG	TG	NNP
cord-006229-7yoilsho	2395	35	)	)	-RRB-
cord-006229-7yoilsho	2395	36	,	,	,
cord-006229-7yoilsho	2395	37	the	the	DT
cord-006229-7yoilsho	2395	38	amplitude	amplitude	NN
cord-006229-7yoilsho	2395	39	was	be	VBD
cord-006229-7yoilsho	2395	40	increased	increase	VBN
cord-006229-7yoilsho	2395	41	by	by	IN
cord-006229-7yoilsho	2395	42	5	5	CD
cord-006229-7yoilsho	2395	43	mV	mV	NNP
cord-006229-7yoilsho	2395	44	(	(	-LRB-
cord-006229-7yoilsho	2395	45	n.s	n.s	NNP
cord-006229-7yoilsho	2395	46	.	.	NNP
cord-006229-7yoilsho	2395	47	)	)	-RRB-
cord-006229-7yoilsho	2395	48	and	and	CC
cord-006229-7yoilsho	2395	49	the	the	DT
cord-006229-7yoilsho	2395	50	slope	slope	NN
cord-006229-7yoilsho	2395	51	of	of	IN
cord-006229-7yoilsho	2395	52	depolarization	depolarization	NN
cord-006229-7yoilsho	2395	53	was	be	VBD
cord-006229-7yoilsho	2395	54	increased	increase	VBN
cord-006229-7yoilsho	2395	55	by	by	IN
cord-006229-7yoilsho	2395	56	21	21	CD
cord-006229-7yoilsho	2395	57	%	%	NN
cord-006229-7yoilsho	2395	58	(	(	-LRB-
cord-006229-7yoilsho	2395	59	p=0.16	p=0.16	NNP
cord-006229-7yoilsho	2395	60	,	,	,
cord-006229-7yoilsho	2395	61	n.s	n.s	NNP
cord-006229-7yoilsho	2395	62	.	.	NNP
cord-006229-7yoilsho	2395	63	)	)	-RRB-
cord-006229-7yoilsho	2395	64	.	.	.
cord-006229-7yoilsho	2396	1	Membrane	membrane	NN
cord-006229-7yoilsho	2396	2	capacitance	capacitance	NN
cord-006229-7yoilsho	2396	3	evaluation	evaluation	NN
cord-006229-7yoilsho	2396	4	,	,	,
cord-006229-7yoilsho	2396	5	as	as	IN
cord-006229-7yoilsho	2396	6	an	an	DT
cord-006229-7yoilsho	2396	7	estimation	estimation	NN
cord-006229-7yoilsho	2396	8	of	of	IN
cord-006229-7yoilsho	2396	9	atrial	atrial	JJ
cord-006229-7yoilsho	2396	10	myocyte	myocyte	NNP
cord-006229-7yoilsho	2396	11	size	size	NN
cord-006229-7yoilsho	2396	12	,	,	,
cord-006229-7yoilsho	2396	13	showed	show	VBD
cord-006229-7yoilsho	2396	14	that	that	IN
cord-006229-7yoilsho	2396	15	in	in	IN
cord-006229-7yoilsho	2396	16	untreated	untreated	JJ
cord-006229-7yoilsho	2396	17	TG	TG	NNP
cord-006229-7yoilsho	2396	18	mice	mouse	NNS
cord-006229-7yoilsho	2396	19	the	the	DT
cord-006229-7yoilsho	2396	20	cells	cell	NNS
cord-006229-7yoilsho	2396	21	were	be	VBD
cord-006229-7yoilsho	2396	22	larger	large	JJR
cord-006229-7yoilsho	2396	23	than	than	IN
cord-006229-7yoilsho	2396	24	in	in	IN
cord-006229-7yoilsho	2396	25	WT	WT	NNP
cord-006229-7yoilsho	2397	1	(	(	-LRB-
cord-006229-7yoilsho	2397	2	TG	TG	NNP
cord-006229-7yoilsho	2397	3	:	:	:
cord-006229-7yoilsho	2398	1	104±7.2	104±7.2	JJ
cord-006229-7yoilsho	2398	2	pF	pF	NNP
cord-006229-7yoilsho	2398	3	,	,	,
cord-006229-7yoilsho	2398	4	n=27	n=27	FW
cord-006229-7yoilsho	2398	5	vs.	vs.	IN
cord-006229-7yoilsho	2398	6	WT	WT	NNP
cord-006229-7yoilsho	2398	7	:	:	:
cord-006229-7yoilsho	2398	8	55±5.4	55±5.4	CD
cord-006229-7yoilsho	2398	9	pF	pF	NNP
cord-006229-7yoilsho	2398	10	,	,	,
cord-006229-7yoilsho	2398	11	n=30	n=30	NNP
cord-006229-7yoilsho	2398	12	,	,	,
cord-006229-7yoilsho	2398	13	p<0.001	p<0.001	CD
cord-006229-7yoilsho	2398	14	)	)	-RRB-
cord-006229-7yoilsho	2398	15	,	,	,
cord-006229-7yoilsho	2398	16	in	in	IN
cord-006229-7yoilsho	2398	17	line	line	NN
cord-006229-7yoilsho	2398	18	with	with	IN
cord-006229-7yoilsho	2398	19	the	the	DT
cord-006229-7yoilsho	2398	20	occurrence	occurrence	NN
cord-006229-7yoilsho	2398	21	of	of	IN
cord-006229-7yoilsho	2398	22	cellular	cellular	JJ
cord-006229-7yoilsho	2398	23	hypertrophy	hypertrophy	NN
cord-006229-7yoilsho	2398	24	in	in	IN
cord-006229-7yoilsho	2398	25	TG	TG	NNP
cord-006229-7yoilsho	2398	26	atria	atria	NN
cord-006229-7yoilsho	2398	27	.	.	.
cord-006229-7yoilsho	2399	1	Chronic	chronic	JJ
cord-006229-7yoilsho	2399	2	VPA	VPA	NNP
cord-006229-7yoilsho	2399	3	treatment	treatment	NN
cord-006229-7yoilsho	2399	4	did	do	VBD
cord-006229-7yoilsho	2399	5	not	not	RB
cord-006229-7yoilsho	2399	6	change	change	VB
cord-006229-7yoilsho	2399	7	the	the	DT
cord-006229-7yoilsho	2399	8	cell	cell	NN
cord-006229-7yoilsho	2399	9	size	size	NN
cord-006229-7yoilsho	2399	10	in	in	IN
cord-006229-7yoilsho	2399	11	either	either	DT
cord-006229-7yoilsho	2399	12	genotype	genotype	NN
cord-006229-7yoilsho	2399	13	(	(	-LRB-
cord-006229-7yoilsho	2399	14	WT	WT	NNP
cord-006229-7yoilsho	2399	15	-	-	HYPH
cord-006229-7yoilsho	2399	16	VPA	VPA	NNP
cord-006229-7yoilsho	2399	17	:	:	:
cord-006229-7yoilsho	2399	18	64.8±7	64.8±7	NNP
cord-006229-7yoilsho	2399	19	pF	pF	NNP
cord-006229-7yoilsho	2399	20	,	,	,
cord-006229-7yoilsho	2399	21	n=17	n=17	NNP
cord-006229-7yoilsho	2399	22	n.s	n.s	NNP
cord-006229-7yoilsho	2399	23	.	.	.
cord-006229-7yoilsho	2400	1	vs.	vs.	IN
cord-006229-7yoilsho	2400	2	WT	WT	NNP
cord-006229-7yoilsho	2400	3	;	;	:
cord-006229-7yoilsho	2400	4	TG	TG	NNP
cord-006229-7yoilsho	2400	5	-	-	HYPH
cord-006229-7yoilsho	2400	6	VPA	VPA	NNP
cord-006229-7yoilsho	2400	7	:	:	:
cord-006229-7yoilsho	2400	8	88±7	88±7	CD
cord-006229-7yoilsho	2400	9	pF	pF	NNP
cord-006229-7yoilsho	2400	10	,	,	,
cord-006229-7yoilsho	2400	11	n=14	n=14	JJ
cord-006229-7yoilsho	2400	12	,	,	,
cord-006229-7yoilsho	2400	13	p<0.05	p<0.05	JJ
cord-006229-7yoilsho	2400	14	vs.	vs.	IN
cord-006229-7yoilsho	2400	15	WT	WT	NNP
cord-006229-7yoilsho	2400	16	-	-	HYPH
cord-006229-7yoilsho	2400	17	VPA	VPA	NNP
cord-006229-7yoilsho	2400	18	;	;	:
cord-006229-7yoilsho	2400	19	p<0.01	p<0.01	NNP
cord-006229-7yoilsho	2400	20	vs.	vs.	IN
cord-006229-7yoilsho	2400	21	WT	WT	NNP
cord-006229-7yoilsho	2400	22	;	;	:
cord-006229-7yoilsho	2400	23	n.s	n.s	NNP
cord-006229-7yoilsho	2400	24	.	.	NNP
cord-006229-7yoilsho	2400	25	vs.	vs.	FW
cord-006229-7yoilsho	2400	26	TG	TG	NNP
cord-006229-7yoilsho	2400	27	)	)	-RRB-
cord-006229-7yoilsho	2400	28	.	.	.
cord-006229-7yoilsho	2401	1	Conclusions	conclusion	NNS
cord-006229-7yoilsho	2401	2	:	:	:
cord-006229-7yoilsho	2402	1	In	in	IN
cord-006229-7yoilsho	2402	2	hypertrophied	hypertrophied	JJ
cord-006229-7yoilsho	2402	3	atrial	atrial	JJ
cord-006229-7yoilsho	2402	4	myocytes	myocyte	NNS
cord-006229-7yoilsho	2402	5	of	of	IN
cord-006229-7yoilsho	2402	6	CREM	CREM	NNP
cord-006229-7yoilsho	2402	7	-	-	HYPH
cord-006229-7yoilsho	2402	8	Ib∆C	Ib∆C	NNP
cord-006229-7yoilsho	2402	9	-	-	HYPH
cord-006229-7yoilsho	2402	10	X	X	NNP
cord-006229-7yoilsho	2402	11	,	,	,
cord-006229-7yoilsho	2402	12	AP	AP	NNP
cord-006229-7yoilsho	2402	13	were	be	VBD
cord-006229-7yoilsho	2402	14	characterized	characterize	VBN
cord-006229-7yoilsho	2402	15	by	by	IN
cord-006229-7yoilsho	2402	16	smaller	small	JJR
cord-006229-7yoilsho	2402	17	amplitude	amplitude	NN
cord-006229-7yoilsho	2402	18	,	,	,
cord-006229-7yoilsho	2402	19	slower	slow	JJR
cord-006229-7yoilsho	2402	20	onset	onset	NN
cord-006229-7yoilsho	2402	21	of	of	IN
cord-006229-7yoilsho	2402	22	depolarization	depolarization	NN
cord-006229-7yoilsho	2402	23	and	and	CC
cord-006229-7yoilsho	2402	24	increased	increase	VBN
cord-006229-7yoilsho	2402	25	duration	duration	NN
cord-006229-7yoilsho	2402	26	compared	compare	VBN
cord-006229-7yoilsho	2402	27	to	to	IN
cord-006229-7yoilsho	2402	28	WT	wt	NN
cord-006229-7yoilsho	2402	29	cells	cell	NNS
cord-006229-7yoilsho	2402	30	.	.	.
cord-006229-7yoilsho	2403	1	Despite	despite	IN
cord-006229-7yoilsho	2403	2	having	have	VBG
cord-006229-7yoilsho	2403	3	no	no	DT
cord-006229-7yoilsho	2403	4	effect	effect	NN
cord-006229-7yoilsho	2403	5	on	on	IN
cord-006229-7yoilsho	2403	6	atrial	atrial	JJ
cord-006229-7yoilsho	2403	7	myocytes	myocyte	NNS
cord-006229-7yoilsho	2403	8	size	size	NN
cord-006229-7yoilsho	2403	9	,	,	,
cord-006229-7yoilsho	2403	10	VPA	VPA	NNP
cord-006229-7yoilsho	2403	11	treatment	treatment	NN
cord-006229-7yoilsho	2403	12	reduced	reduce	VBD
cord-006229-7yoilsho	2403	13	the	the	DT
cord-006229-7yoilsho	2403	14	duration	duration	NN
cord-006229-7yoilsho	2403	15	and	and	CC
cord-006229-7yoilsho	2403	16	showed	show	VBD
cord-006229-7yoilsho	2403	17	a	a	DT
cord-006229-7yoilsho	2403	18	tendency	tendency	NN
cord-006229-7yoilsho	2403	19	to	to	TO
cord-006229-7yoilsho	2403	20	increase	increase	VB
cord-006229-7yoilsho	2403	21	the	the	DT
cord-006229-7yoilsho	2403	22	amplitude	amplitude	NN
cord-006229-7yoilsho	2403	23	and	and	CC
cord-006229-7yoilsho	2403	24	the	the	DT
cord-006229-7yoilsho	2403	25	slope	slope	NN
cord-006229-7yoilsho	2403	26	of	of	IN
cord-006229-7yoilsho	2403	27	depolarization	depolarization	NN
cord-006229-7yoilsho	2403	28	of	of	IN
cord-006229-7yoilsho	2403	29	the	the	DT
cord-006229-7yoilsho	2403	30	action	action	NN
cord-006229-7yoilsho	2403	31	potential	potential	NN
cord-006229-7yoilsho	2403	32	in	in	IN
cord-006229-7yoilsho	2403	33	TG	TG	NNP
cord-006229-7yoilsho	2403	34	mice	mouse	NNS
cord-006229-7yoilsho	2403	35	to	to	IN
cord-006229-7yoilsho	2403	36	values	value	NNS
cord-006229-7yoilsho	2403	37	similar	similar	JJ
cord-006229-7yoilsho	2403	38	to	to	IN
cord-006229-7yoilsho	2403	39	WT	WT	NNP
cord-006229-7yoilsho	2403	40	.	.	.
cord-006229-7yoilsho	2404	1	These	these	DT
cord-006229-7yoilsho	2404	2	data	datum	NNS
cord-006229-7yoilsho	2404	3	suggest	suggest	VBP
cord-006229-7yoilsho	2404	4	that	that	IN
cord-006229-7yoilsho	2404	5	chronic	chronic	JJ
cord-006229-7yoilsho	2404	6	treatment	treatment	NN
cord-006229-7yoilsho	2404	7	with	with	IN
cord-006229-7yoilsho	2404	8	VPA	VPA	NNP
cord-006229-7yoilsho	2404	9	restored	restore	VBD
cord-006229-7yoilsho	2404	10	partially	partially	RB
cord-006229-7yoilsho	2404	11	the	the	DT
cord-006229-7yoilsho	2404	12	electrical	electrical	JJ
cord-006229-7yoilsho	2404	13	activity	activity	NN
cord-006229-7yoilsho	2404	14	of	of	IN
cord-006229-7yoilsho	2404	15	atrial	atrial	JJ
cord-006229-7yoilsho	2404	16	myocytes	myocyte	NNS
cord-006229-7yoilsho	2404	17	and	and	CC
cord-006229-7yoilsho	2404	18	may	may	MD
cord-006229-7yoilsho	2404	19	reverse	reverse	VB
cord-006229-7yoilsho	2404	20	the	the	DT
cord-006229-7yoilsho	2404	21	electrical	electrical	JJ
cord-006229-7yoilsho	2404	22	remodeling	remodeling	NN
cord-006229-7yoilsho	2404	23	via	via	IN
cord-006229-7yoilsho	2404	24	HDAC2	HDAC2	NNP
cord-006229-7yoilsho	2404	25	inhibition	inhibition	NN
cord-006229-7yoilsho	2404	26	.	.	.
cord-006229-7yoilsho	2405	1	(	(	-LRB-
cord-006229-7yoilsho	2405	2	Supported	support	VBN
cord-006229-7yoilsho	2405	3	by	by	IN
cord-006229-7yoilsho	2405	4	the	the	DT
cord-006229-7yoilsho	2405	5	DFG	DFG	NNP
cord-006229-7yoilsho	2405	6	)	)	-RRB-
cord-006229-7yoilsho	2405	7	of	of	IN
cord-006229-7yoilsho	2405	8	the	the	DT
cord-006229-7yoilsho	2405	9	transcription	transcription	NN
cord-006229-7yoilsho	2405	10	factor	factor	NN
cord-006229-7yoilsho	2405	11	CREM	CREM	NNP
cord-006229-7yoilsho	2405	12	(	(	-LRB-
cord-006229-7yoilsho	2405	13	cAMP	camp	NN
cord-006229-7yoilsho	2405	14	response	response	NN
cord-006229-7yoilsho	2405	15	modulator	modulator	NN
cord-006229-7yoilsho	2405	16	)	)	-RRB-
cord-006229-7yoilsho	2405	17	ICER	ICER	NNP
cord-006229-7yoilsho	2405	18	,	,	,
cord-006229-7yoilsho	2405	19	smICER	smicer	NN
cord-006229-7yoilsho	2405	20	and	and	CC
cord-006229-7yoilsho	2406	1	CREM	CREM	NNP
cord-006229-7yoilsho	2406	2	-	-	HYPH
cord-006229-7yoilsho	2406	3	Ib∆C	Ib∆C	NNP
cord-006229-7yoilsho	2406	4	-	-	HYPH
cord-006229-7yoilsho	2406	5	X	X	NNP
cord-006229-7yoilsho	2406	6	are	be	VBP
cord-006229-7yoilsho	2406	7	inducible	inducible	JJ
cord-006229-7yoilsho	2406	8	by	by	IN
cord-006229-7yoilsho	2406	9	β	β	NN
cord-006229-7yoilsho	2406	10	-	-	HYPH
cord-006229-7yoilsho	2406	11	adrenergic	adrenergic	JJ
cord-006229-7yoilsho	2406	12	stimulation	stimulation	NN
cord-006229-7yoilsho	2406	13	and	and	CC
cord-006229-7yoilsho	2406	14	code	code	NN
cord-006229-7yoilsho	2406	15	for	for	IN
cord-006229-7yoilsho	2406	16	similar	similar	JJ
cord-006229-7yoilsho	2406	17	or	or	CC
cord-006229-7yoilsho	2406	18	even	even	RB
cord-006229-7yoilsho	2406	19	identical	identical	JJ
cord-006229-7yoilsho	2406	20	proteins	protein	NNS
cord-006229-7yoilsho	2406	21	.	.	.
cord-006229-7yoilsho	2407	1	Thus	thus	RB
cord-006229-7yoilsho	2407	2	,	,	,
cord-006229-7yoilsho	2407	3	these	these	DT
cord-006229-7yoilsho	2407	4	isoforms	isoform	NNS
cord-006229-7yoilsho	2407	5	are	be	VBP
cord-006229-7yoilsho	2407	6	able	able	JJ
cord-006229-7yoilsho	2407	7	to	to	TO
cord-006229-7yoilsho	2407	8	repress	repress	VB
cord-006229-7yoilsho	2407	9	expression	expression	NN
cord-006229-7yoilsho	2407	10	of	of	IN
cord-006229-7yoilsho	2407	11	respective	respective	JJ
cord-006229-7yoilsho	2407	12	target	target	NN
cord-006229-7yoilsho	2407	13	genes	gene	NNS
cord-006229-7yoilsho	2407	14	in	in	IN
cord-006229-7yoilsho	2407	15	response	response	NN
cord-006229-7yoilsho	2407	16	to	to	IN
cord-006229-7yoilsho	2407	17	cAMP	camp	NN
cord-006229-7yoilsho	2407	18	and	and	CC
cord-006229-7yoilsho	2407	19	might	may	MD
cord-006229-7yoilsho	2407	20	play	play	VB
cord-006229-7yoilsho	2407	21	a	a	DT
cord-006229-7yoilsho	2407	22	role	role	NN
cord-006229-7yoilsho	2407	23	in	in	IN
cord-006229-7yoilsho	2407	24	an	an	DT
cord-006229-7yoilsho	2407	25	arrhythmogenic	arrhythmogenic	JJ
cord-006229-7yoilsho	2407	26	remodeling	remodeling	NN
cord-006229-7yoilsho	2407	27	during	during	IN
cord-006229-7yoilsho	2407	28	the	the	DT
cord-006229-7yoilsho	2407	29	development	development	NN
cord-006229-7yoilsho	2407	30	of	of	IN
cord-006229-7yoilsho	2407	31	chronic	chronic	JJ
cord-006229-7yoilsho	2407	32	heart	heart	NN
cord-006229-7yoilsho	2407	33	diseases	disease	NNS
cord-006229-7yoilsho	2407	34	.	.	.
cord-006229-7yoilsho	2408	1	Here	here	RB
cord-006229-7yoilsho	2408	2	we	-PRON-	PRP
cord-006229-7yoilsho	2408	3	test	test	VBP
cord-006229-7yoilsho	2408	4	this	this	DT
cord-006229-7yoilsho	2408	5	hypothesis	hypothesis	NN
cord-006229-7yoilsho	2408	6	in	in	IN
cord-006229-7yoilsho	2408	7	a	a	DT
cord-006229-7yoilsho	2408	8	mouse	mouse	NN
cord-006229-7yoilsho	2408	9	model	model	NN
cord-006229-7yoilsho	2408	10	with	with	IN
cord-006229-7yoilsho	2408	11	transgenic	transgenic	JJ
cord-006229-7yoilsho	2408	12	expression	expression	NN
cord-006229-7yoilsho	2408	13	of	of	IN
cord-006229-7yoilsho	2408	14	CREM	CREM	NNP
cord-006229-7yoilsho	2408	15	-	-	HYPH
cord-006229-7yoilsho	2408	16	Ib∆C	Ib∆C	NNP
cord-006229-7yoilsho	2408	17	-	-	HYPH
cord-006229-7yoilsho	2408	18	X	x	NN
cord-006229-7yoilsho	2408	19	(	(	-LRB-
cord-006229-7yoilsho	2408	20	TG	TG	NNP
cord-006229-7yoilsho	2408	21	)	)	-RRB-
cord-006229-7yoilsho	2408	22	.	.	.
cord-006229-7yoilsho	2409	1	These	these	DT
cord-006229-7yoilsho	2409	2	mice	mouse	NNS
cord-006229-7yoilsho	2409	3	develop	develop	VBP
cord-006229-7yoilsho	2409	4	not	not	RB
cord-006229-7yoilsho	2409	5	only	only	RB
cord-006229-7yoilsho	2409	6	spontaneous	spontaneous	JJ
cord-006229-7yoilsho	2409	7	onset	onset	NN
cord-006229-7yoilsho	2409	8	atrial	atrial	JJ
cord-006229-7yoilsho	2409	9	fibrillation	fibrillation	NN
cord-006229-7yoilsho	2409	10	but	but	CC
cord-006229-7yoilsho	2409	11	likewise	likewise	RB
cord-006229-7yoilsho	2409	12	arrhythmogenic	arrhythmogenic	NNP
cord-006229-7yoilsho	2409	13	alterations	alteration	NNS
cord-006229-7yoilsho	2409	14	in	in	IN
cord-006229-7yoilsho	2409	15	the	the	DT
cord-006229-7yoilsho	2409	16	ventricle	ventricle	NN
cord-006229-7yoilsho	2409	17	.	.	.
cord-006229-7yoilsho	2410	1	Patch	patch	NN
cord-006229-7yoilsho	2410	2	clamp	clamp	NN
cord-006229-7yoilsho	2410	3	experiments	experiment	NNS
cord-006229-7yoilsho	2410	4	revealed	reveal	VBD
cord-006229-7yoilsho	2410	5	an	an	DT
cord-006229-7yoilsho	2410	6	increased	increase	VBN
cord-006229-7yoilsho	2410	7	Na	Na	NNP
cord-006229-7yoilsho	2411	1	+	+	CC
cord-006229-7yoilsho	2411	2	-Ca	-ca	$
cord-006229-7yoilsho	2411	3	2	2	CD
cord-006229-7yoilsho	2412	1	+	+	CC
cord-006229-7yoilsho	2412	2	exchanger	exchanger	NN
cord-006229-7yoilsho	2412	3	current	current	NN
cord-006229-7yoilsho	2412	4	(	(	-LRB-
cord-006229-7yoilsho	2412	5	I	-PRON-	PRP
cord-006229-7yoilsho	2412	6	NCX	NCX	NNP
cord-006229-7yoilsho	2412	7	)	)	-RRB-
cord-006229-7yoilsho	2412	8	and	and	CC
cord-006229-7yoilsho	2412	9	decreased	decrease	VBD
cord-006229-7yoilsho	2412	10	transient	transient	JJ
cord-006229-7yoilsho	2412	11	outward	outward	JJ
cord-006229-7yoilsho	2412	12	current	current	NN
cord-006229-7yoilsho	2412	13	(	(	-LRB-
cord-006229-7yoilsho	2412	14	I	-PRON-	PRP
cord-006229-7yoilsho	2412	15	to	to	IN
cord-006229-7yoilsho	2412	16	)	)	-RRB-
cord-006229-7yoilsho	2413	1	in	in	IN
cord-006229-7yoilsho	2413	2	TG	TG	NNP
cord-006229-7yoilsho	2413	3	ventricular	ventricular	JJ
cord-006229-7yoilsho	2413	4	cardiomyocytes	cardiomyocyte	NNS
cord-006229-7yoilsho	2413	5	(	(	-LRB-
cord-006229-7yoilsho	2413	6	VCMs	VCMs	NNP
cord-006229-7yoilsho	2413	7	)	)	-RRB-
cord-006229-7yoilsho	2413	8	vs.	vs.	FW
cord-006229-7yoilsho	2413	9	wild	wild	JJ
cord-006229-7yoilsho	2413	10	-	-	HYPH
cord-006229-7yoilsho	2413	11	type	type	NN
cord-006229-7yoilsho	2413	12	controls	control	NNS
cord-006229-7yoilsho	2413	13	(	(	-LRB-
cord-006229-7yoilsho	2413	14	CTL	CTL	NNP
cord-006229-7yoilsho	2413	15	)	)	-RRB-
cord-006229-7yoilsho	2413	16	.	.	.
cord-006229-7yoilsho	2414	1	These	these	DT
cord-006229-7yoilsho	2414	2	alterations	alteration	NNS
cord-006229-7yoilsho	2414	3	were	be	VBD
cord-006229-7yoilsho	2414	4	associated	associate	VBN
cord-006229-7yoilsho	2414	5	with	with	IN
cord-006229-7yoilsho	2414	6	an	an	DT
cord-006229-7yoilsho	2414	7	increased	increase	VBN
cord-006229-7yoilsho	2414	8	arrhythmogenicity	arrhythmogenicity	NN
cord-006229-7yoilsho	2414	9	in	in	IN
cord-006229-7yoilsho	2414	10	TG	TG	NNP
cord-006229-7yoilsho	2414	11	VCMs	VCMs	NNP
cord-006229-7yoilsho	2414	12	.	.	.
cord-006229-7yoilsho	2415	1	Action	action	NN
cord-006229-7yoilsho	2415	2	potentials	potential	NNS
cord-006229-7yoilsho	2415	3	were	be	VBD
cord-006229-7yoilsho	2415	4	prolonged	prolong	VBN
cord-006229-7yoilsho	2415	5	in	in	IN
cord-006229-7yoilsho	2415	6	TG	TG	NNP
cord-006229-7yoilsho	2415	7	VCMs	VCMs	NNP
cord-006229-7yoilsho	2415	8	vs.	vs.	IN
cord-006229-7yoilsho	2415	9	CTLs	ctl	NNS
cord-006229-7yoilsho	2415	10	leading	lead	VBG
cord-006229-7yoilsho	2415	11	to	to	IN
cord-006229-7yoilsho	2415	12	an	an	DT
cord-006229-7yoilsho	2415	13	increased	increase	VBN
cord-006229-7yoilsho	2415	14	proportion	proportion	NN
cord-006229-7yoilsho	2415	15	of	of	IN
cord-006229-7yoilsho	2415	16	VCMs	vcms	NN
cord-006229-7yoilsho	2415	17	displaying	display	VBG
cord-006229-7yoilsho	2415	18	early	early	JJ
cord-006229-7yoilsho	2415	19	afterdepolarizations	afterdepolarization	NNS
cord-006229-7yoilsho	2415	20	.	.	.
cord-006229-7yoilsho	2416	1	Ca	ca	NN
cord-006229-7yoilsho	2416	2	2	2	CD
cord-006229-7yoilsho	2416	3	+	+	CD
cord-006229-7yoilsho	2416	4	imaging	imaging	NN
cord-006229-7yoilsho	2416	5	revealed	reveal	VBD
cord-006229-7yoilsho	2416	6	that	that	IN
cord-006229-7yoilsho	2416	7	the	the	DT
cord-006229-7yoilsho	2416	8	transduction	transduction	NN
cord-006229-7yoilsho	2416	9	rate	rate	NN
cord-006229-7yoilsho	2416	10	of	of	IN
cord-006229-7yoilsho	2416	11	spontaneous	spontaneous	JJ
cord-006229-7yoilsho	2416	12	sub	sub	NN
cord-006229-7yoilsho	2416	13	-	-	NN
cord-006229-7yoilsho	2416	14	threshold	threshold	NN
cord-006229-7yoilsho	2417	1	Ca	ca	NN
cord-006229-7yoilsho	2417	2	2	2	CD
cord-006229-7yoilsho	2417	3	+	+	CD
cord-006229-7yoilsho	2418	1	-waves	-waves	:
cord-006229-7yoilsho	2418	2	into	into	IN
cord-006229-7yoilsho	2418	3	supra	supra	NN
cord-006229-7yoilsho	2418	4	-	-	HYPH
cord-006229-7yoilsho	2418	5	threshold	threshold	NN
cord-006229-7yoilsho	2419	1	transient	transient	JJ
cord-006229-7yoilsho	2419	2	-	-	HYPH
cord-006229-7yoilsho	2419	3	like	like	JJ
cord-006229-7yoilsho	2419	4	Ca	Ca	NNP
cord-006229-7yoilsho	2419	5	2	2	CD
cord-006229-7yoilsho	2420	1	+	+	LS
cord-006229-7yoilsho	2420	2	-events	-event	NNS
cord-006229-7yoilsho	2421	1	which	which	WDT
cord-006229-7yoilsho	2421	2	is	be	VBZ
cord-006229-7yoilsho	2421	3	mediated	mediate	VBN
cord-006229-7yoilsho	2421	4	by	by	IN
cord-006229-7yoilsho	2421	5	the	the	DT
cord-006229-7yoilsho	2421	6	NCX	NCX	NNP
cord-006229-7yoilsho	2421	7	was	be	VBD
cord-006229-7yoilsho	2421	8	increased	increase	VBN
cord-006229-7yoilsho	2421	9	in	in	IN
cord-006229-7yoilsho	2421	10	TG	TG	NNP
cord-006229-7yoilsho	2421	11	VCMs	VCMs	NNP
cord-006229-7yoilsho	2421	12	.	.	.
cord-006229-7yoilsho	2422	1	At	at	IN
cord-006229-7yoilsho	2422	2	the	the	DT
cord-006229-7yoilsho	2422	3	same	same	JJ
cord-006229-7yoilsho	2422	4	time	time	NN
cord-006229-7yoilsho	2422	5	the	the	DT
cord-006229-7yoilsho	2422	6	SERCA	SERCA	NNP
cord-006229-7yoilsho	2422	7	mediated	mediate	VBD
cord-006229-7yoilsho	2423	1	Ca	ca	NN
cord-006229-7yoilsho	2423	2	2	2	CD
cord-006229-7yoilsho	2423	3	+	+	SYM
cord-006229-7yoilsho	2423	4	transport	transport	NN
cord-006229-7yoilsho	2423	5	rate	rate	NN
cord-006229-7yoilsho	2423	6	(	(	-LRB-
cord-006229-7yoilsho	2423	7	r	r	NNP
cord-006229-7yoilsho	2423	8	SERCA	SERCA	NNP
cord-006229-7yoilsho	2423	9	)	)	-RRB-
cord-006229-7yoilsho	2423	10	was	be	VBD
cord-006229-7yoilsho	2423	11	enhanced	enhance	VBN
cord-006229-7yoilsho	2423	12	in	in	IN
cord-006229-7yoilsho	2423	13	TG	TG	NNP
cord-006229-7yoilsho	2423	14	VCMs	VCMs	NNP
cord-006229-7yoilsho	2423	15	potentially	potentially	RB
cord-006229-7yoilsho	2423	16	limiting	limit	VBG
cord-006229-7yoilsho	2423	17	Ca	Ca	NNP
cord-006229-7yoilsho	2423	18	2	2	CD
cord-006229-7yoilsho	2423	19	+	+	CC
cord-006229-7yoilsho	2423	20	extrusion	extrusion	NN
cord-006229-7yoilsho	2423	21	by	by	IN
cord-006229-7yoilsho	2423	22	the	the	DT
cord-006229-7yoilsho	2423	23	NCX	NCX	NNP
cord-006229-7yoilsho	2423	24	.	.	.
cord-006229-7yoilsho	2424	1	Underlining	underline	VBG
cord-006229-7yoilsho	2424	2	the	the	DT
cord-006229-7yoilsho	2424	3	in	in	IN
cord-006229-7yoilsho	2424	4	-	-	HYPH
cord-006229-7yoilsho	2424	5	vivo	vivo	NN
cord-006229-7yoilsho	2424	6	relevance	relevance	NN
cord-006229-7yoilsho	2424	7	of	of	IN
cord-006229-7yoilsho	2424	8	our	-PRON-	PRP$
cord-006229-7yoilsho	2424	9	findings	finding	NNS
cord-006229-7yoilsho	2424	10	ventricular	ventricular	JJ
cord-006229-7yoilsho	2424	11	extrasystoles	extrasystole	NNS
cord-006229-7yoilsho	2424	12	(	(	-LRB-
cord-006229-7yoilsho	2424	13	VES	VES	NNP
cord-006229-7yoilsho	2424	14	)	)	-RRB-
cord-006229-7yoilsho	2424	15	were	be	VBD
cord-006229-7yoilsho	2424	16	augmented	augment	VBN
cord-006229-7yoilsho	2424	17	in	in	IN
cord-006229-7yoilsho	2424	18	ECGs	ecg	NNS
cord-006229-7yoilsho	2424	19	of	of	IN
cord-006229-7yoilsho	2424	20	TG	TG	NNP
cord-006229-7yoilsho	2424	21	mice	mouse	NNS
cord-006229-7yoilsho	2424	22	(	(	-LRB-
cord-006229-7yoilsho	2424	23	VES	VES	NNP
cord-006229-7yoilsho	2424	24	/	/	SYM
cord-006229-7yoilsho	2424	25	mouse	mouse	NN
cord-006229-7yoilsho	2424	26	during	during	IN
cord-006229-7yoilsho	2424	27	10	10	CD
cord-006229-7yoilsho	2424	28	-6	-6	NNP
cord-006229-7yoilsho	2424	29	M	M	NNP
cord-006229-7yoilsho	2424	30	isoproterenol	isoproterenol	NN
cord-006229-7yoilsho	2424	31	challenge	challenge	NN
cord-006229-7yoilsho	2424	32	,	,	,
cord-006229-7yoilsho	2424	33	TG	TG	NNP
cord-006229-7yoilsho	2424	34	:	:	:
cord-006229-7yoilsho	2424	35	3.65	3.65	CD
cord-006229-7yoilsho	2424	36	*	*	NFP
cord-006229-7yoilsho	2424	37	,	,	,
cord-006229-7yoilsho	2424	38	CTL	CTL	NNP
cord-006229-7yoilsho	2424	39	:	:	:
cord-006229-7yoilsho	2424	40	0.4	0.4	CD
cord-006229-7yoilsho	2424	41	;	;	:
cord-006229-7yoilsho	2424	42	n=20	n=20	NNP
cord-006229-7yoilsho	2424	43	/	/	SYM
cord-006229-7yoilsho	2424	44	condition	condition	NN
cord-006229-7yoilsho	2424	45	)	)	-RRB-
cord-006229-7yoilsho	2424	46	.	.	.
cord-006229-7yoilsho	2425	1	The	the	DT
cord-006229-7yoilsho	2425	2	increase	increase	NN
cord-006229-7yoilsho	2425	3	in	in	IN
cord-006229-7yoilsho	2425	4	I	-PRON-	PRP
cord-006229-7yoilsho	2425	5	NCX	NCX	NNP
cord-006229-7yoilsho	2425	6	and	and	CC
cord-006229-7yoilsho	2425	7	r	r	NNP
cord-006229-7yoilsho	2425	8	SERCA	SERCA	NNP
cord-006229-7yoilsho	2425	9	and	and	CC
cord-006229-7yoilsho	2425	10	the	the	DT
cord-006229-7yoilsho	2425	11	decrease	decrease	NN
cord-006229-7yoilsho	2425	12	in	in	IN
cord-006229-7yoilsho	2425	13	I	-PRON-	PRP
cord-006229-7yoilsho	2425	14	to	to	TO
cord-006229-7yoilsho	2425	15	went	go	VBD
cord-006229-7yoilsho	2425	16	along	along	RP
cord-006229-7yoilsho	2425	17	with	with	IN
cord-006229-7yoilsho	2425	18	an	an	DT
cord-006229-7yoilsho	2425	19	increase	increase	NN
cord-006229-7yoilsho	2425	20	of	of	IN
cord-006229-7yoilsho	2425	21	NCX1	NCX1	NNP
cord-006229-7yoilsho	2425	22	,	,	,
cord-006229-7yoilsho	2425	23	SERCA2a	serca2a	NN
cord-006229-7yoilsho	2425	24	and	and	CC
cord-006229-7yoilsho	2425	25	decrease	decrease	NN
cord-006229-7yoilsho	2425	26	of	of	IN
cord-006229-7yoilsho	2425	27	KChIP2	KChIP2	NNP
cord-006229-7yoilsho	2425	28	protein	protein	NN
cord-006229-7yoilsho	2425	29	levels	level	NNS
cord-006229-7yoilsho	2425	30	.	.	.
cord-006229-7yoilsho	2426	1	However	however	RB
cord-006229-7yoilsho	2426	2	,	,	,
cord-006229-7yoilsho	2426	3	the	the	DT
cord-006229-7yoilsho	2426	4	respective	respective	JJ
cord-006229-7yoilsho	2426	5	mRNA	mRNA	NNP
cord-006229-7yoilsho	2426	6	levels	level	NNS
cord-006229-7yoilsho	2426	7	(	(	-LRB-
cord-006229-7yoilsho	2426	8	Slc8a1	Slc8a1	NNP
cord-006229-7yoilsho	2426	9	,	,	,
cord-006229-7yoilsho	2426	10	Atp2a2	Atp2a2	NNP
cord-006229-7yoilsho	2426	11	and	and	CC
cord-006229-7yoilsho	2426	12	Kcnip2	Kcnip2	NNP
cord-006229-7yoilsho	2426	13	)	)	-RRB-
cord-006229-7yoilsho	2426	14	were	be	VBD
cord-006229-7yoilsho	2426	15	unaltered	unaltered	JJ
cord-006229-7yoilsho	2426	16	between	between	IN
cord-006229-7yoilsho	2426	17	groups	group	NNS
cord-006229-7yoilsho	2426	18	pointing	point	VBG
cord-006229-7yoilsho	2426	19	to	to	IN
cord-006229-7yoilsho	2426	20	a	a	DT
cord-006229-7yoilsho	2426	21	post	post	JJ
cord-006229-7yoilsho	2426	22	-	-	JJ
cord-006229-7yoilsho	2426	23	transcriptional	transcriptional	JJ
cord-006229-7yoilsho	2426	24	regulation	regulation	NN
cord-006229-7yoilsho	2426	25	of	of	IN
cord-006229-7yoilsho	2426	26	these	these	DT
cord-006229-7yoilsho	2426	27	genes	gene	NNS
cord-006229-7yoilsho	2426	28	.	.	.
cord-006229-7yoilsho	2427	1	In	in	IN
cord-006229-7yoilsho	2427	2	a	a	DT
cord-006229-7yoilsho	2427	3	mRNAsequencing	mrnasequencing	NN
cord-006229-7yoilsho	2427	4	approach	approach	NN
cord-006229-7yoilsho	2427	5	we	-PRON-	PRP
cord-006229-7yoilsho	2427	6	identified	identify	VBD
cord-006229-7yoilsho	2427	7	the	the	DT
cord-006229-7yoilsho	2427	8	downregulation	downregulation	NN
cord-006229-7yoilsho	2427	9	of	of	IN
cord-006229-7yoilsho	2427	10	precursor	precursor	NN
cord-006229-7yoilsho	2427	11	miRNAs	miRNAs	NNP
cord-006229-7yoilsho	2427	12	inter	inter	NNP
cord-006229-7yoilsho	2427	13	alia	alia	VBD
cord-006229-7yoilsho	2427	14	for	for	IN
cord-006229-7yoilsho	2427	15	Mir-369	Mir-369	NNP
cord-006229-7yoilsho	2427	16	(	(	-LRB-
cord-006229-7yoilsho	2427	17	Fold	fold	JJ
cord-006229-7yoilsho	2427	18	change	change	NN
cord-006229-7yoilsho	2427	19	in	in	IN
cord-006229-7yoilsho	2427	20	TG	TG	NNP
cord-006229-7yoilsho	2427	21	:	:	:
cord-006229-7yoilsho	2427	22	0.04	0.04	CD
cord-006229-7yoilsho	2427	23	*	*	NFP
cord-006229-7yoilsho	2427	24	)	)	-RRB-
cord-006229-7yoilsho	2427	25	and	and	CC
cord-006229-7yoilsho	2428	1	Mir-1	Mir-1	NNP
cord-006229-7yoilsho	2428	2	(	(	-LRB-
cord-006229-7yoilsho	2428	3	Fold	fold	VB
cord-006229-7yoilsho	2428	4	change	change	NN
cord-006229-7yoilsho	2428	5	in	in	IN
cord-006229-7yoilsho	2428	6	TG	TG	NNP
cord-006229-7yoilsho	2428	7	:	:	:
cord-006229-7yoilsho	2428	8	0.13	0.13	CD
cord-006229-7yoilsho	2428	9	*	*	NFP
cord-006229-7yoilsho	2428	10	)	)	-RRB-
cord-006229-7yoilsho	2429	1	(	(	-LRB-
cord-006229-7yoilsho	2429	2	n=10	n=10	NNP
cord-006229-7yoilsho	2429	3	/	/	SYM
cord-006229-7yoilsho	2429	4	condition	condition	NN
cord-006229-7yoilsho	2429	5	)	)	-RRB-
cord-006229-7yoilsho	2429	6	.	.	.
cord-006229-7yoilsho	2430	1	Atp2a2	Atp2a2	NNP
cord-006229-7yoilsho	2430	2	is	be	VBZ
cord-006229-7yoilsho	2430	3	a	a	DT
cord-006229-7yoilsho	2430	4	predicted	predict	VBN
cord-006229-7yoilsho	2430	5	target	target	NN
cord-006229-7yoilsho	2430	6	of	of	IN
cord-006229-7yoilsho	2430	7	Mir-369	Mir-369	NNP
cord-006229-7yoilsho	2430	8	and	and	CC
cord-006229-7yoilsho	2430	9	Mir-1	Mir-1	NNP
cord-006229-7yoilsho	2430	10	has	have	VBZ
cord-006229-7yoilsho	2430	11	recently	recently	RB
cord-006229-7yoilsho	2430	12	been	be	VBN
cord-006229-7yoilsho	2430	13	shown	show	VBN
cord-006229-7yoilsho	2430	14	to	to	TO
cord-006229-7yoilsho	2430	15	regulate	regulate	VB
cord-006229-7yoilsho	2430	16	NCX1	NCX1	NNP
cord-006229-7yoilsho	2430	17	and	and	CC
cord-006229-7yoilsho	2430	18	I	-PRON-	PRP
cord-006229-7yoilsho	2430	19	to	to	IN
cord-006229-7yoilsho	2430	20	related	related	JJ
cord-006229-7yoilsho	2430	21	potassium	potassium	NN
cord-006229-7yoilsho	2430	22	channel	channel	NN
cord-006229-7yoilsho	2430	23	subunits	subunit	NNS
cord-006229-7yoilsho	2430	24	.	.	.
cord-006229-7yoilsho	2431	1	(	(	-LRB-
cord-006229-7yoilsho	2431	2	*	*	NFP
cord-006229-7yoilsho	2431	3	p<0.05	p<0.05	JJ
cord-006229-7yoilsho	2431	4	vs.	vs.	IN
cord-006229-7yoilsho	2431	5	CTL	CTL	NNP
cord-006229-7yoilsho	2431	6	)	)	-RRB-
cord-006229-7yoilsho	2432	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	2432	2	results	result	NNS
cord-006229-7yoilsho	2432	3	demonstrate	demonstrate	VBP
cord-006229-7yoilsho	2432	4	that	that	IN
cord-006229-7yoilsho	2432	5	transgenic	transgenic	JJ
cord-006229-7yoilsho	2432	6	expression	expression	NN
cord-006229-7yoilsho	2432	7	of	of	IN
cord-006229-7yoilsho	2432	8	CREM	CREM	NNP
cord-006229-7yoilsho	2432	9	-	-	HYPH
cord-006229-7yoilsho	2432	10	Ib∆C	Ib∆C	NNP
cord-006229-7yoilsho	2432	11	-	-	HYPH
cord-006229-7yoilsho	2432	12	X	x	NN
cord-006229-7yoilsho	2432	13	in	in	IN
cord-006229-7yoilsho	2432	14	mouse	mouse	NN
cord-006229-7yoilsho	2432	15	VCMs	vcms	NN
cord-006229-7yoilsho	2432	16	leads	lead	VBZ
cord-006229-7yoilsho	2432	17	to	to	IN
cord-006229-7yoilsho	2432	18	distinct	distinct	JJ
cord-006229-7yoilsho	2432	19	arrhythmogenic	arrhythmogenic	JJ
cord-006229-7yoilsho	2432	20	alterations	alteration	NNS
cord-006229-7yoilsho	2432	21	.	.	.
cord-006229-7yoilsho	2433	1	They	-PRON-	PRP
cord-006229-7yoilsho	2433	2	further	further	RB
cord-006229-7yoilsho	2433	3	indicate	indicate	VBP
cord-006229-7yoilsho	2433	4	that	that	IN
cord-006229-7yoilsho	2433	5	the	the	DT
cord-006229-7yoilsho	2433	6	repression	repression	NN
cord-006229-7yoilsho	2433	7	of	of	IN
cord-006229-7yoilsho	2433	8	micro	micro	JJ
cord-006229-7yoilsho	2433	9	RNAs	rna	NNS
cord-006229-7yoilsho	2433	10	by	by	IN
cord-006229-7yoilsho	2433	11	short	short	JJ
cord-006229-7yoilsho	2433	12	CREM	CREM	NNP
cord-006229-7yoilsho	2433	13	repressor	repressor	NN
cord-006229-7yoilsho	2433	14	isoforms	isoform	NNS
cord-006229-7yoilsho	2433	15	may	may	MD
cord-006229-7yoilsho	2433	16	lead	lead	VB
cord-006229-7yoilsho	2433	17	to	to	IN
cord-006229-7yoilsho	2433	18	the	the	DT
cord-006229-7yoilsho	2433	19	upregulation	upregulation	NN
cord-006229-7yoilsho	2433	20	of	of	IN
cord-006229-7yoilsho	2433	21	genes	gene	NNS
cord-006229-7yoilsho	2433	22	in	in	IN
cord-006229-7yoilsho	2433	23	the	the	DT
cord-006229-7yoilsho	2433	24	context	context	NN
cord-006229-7yoilsho	2433	25	of	of	IN
cord-006229-7yoilsho	2433	26	an	an	DT
cord-006229-7yoilsho	2433	27	arrhythmogenic	arrhythmogenic	JJ
cord-006229-7yoilsho	2433	28	remodeling	remodeling	NN
cord-006229-7yoilsho	2433	29	.	.	.
cord-006229-7yoilsho	2434	1	Since	since	IN
cord-006229-7yoilsho	2434	2	CREM	crem	NN
cord-006229-7yoilsho	2434	3	-	-	HYPH
cord-006229-7yoilsho	2434	4	repressors	repressor	NNS
cord-006229-7yoilsho	2434	5	are	be	VBP
cord-006229-7yoilsho	2434	6	inducible	inducible	JJ
cord-006229-7yoilsho	2434	7	by	by	IN
cord-006229-7yoilsho	2434	8	chronic	chronic	JJ
cord-006229-7yoilsho	2434	9	β	β	NN
cord-006229-7yoilsho	2434	10	-	-	HYPH
cord-006229-7yoilsho	2434	11	adrenergic	adrenergic	NN
cord-006229-7yoilsho	2434	12	stimulation	stimulation	NN
cord-006229-7yoilsho	2434	13	our	-PRON-	PRP$
cord-006229-7yoilsho	2434	14	results	result	NNS
cord-006229-7yoilsho	2434	15	suggest	suggest	VBP
cord-006229-7yoilsho	2434	16	that	that	IN
cord-006229-7yoilsho	2434	17	the	the	DT
cord-006229-7yoilsho	2434	18	inhibition	inhibition	NN
cord-006229-7yoilsho	2434	19	of	of	IN
cord-006229-7yoilsho	2434	20	CREdependent	credependent	NN
cord-006229-7yoilsho	2434	21	transcription	transcription	NN
cord-006229-7yoilsho	2434	22	contributes	contribute	VBZ
cord-006229-7yoilsho	2434	23	to	to	IN
cord-006229-7yoilsho	2434	24	the	the	DT
cord-006229-7yoilsho	2434	25	formation	formation	NN
cord-006229-7yoilsho	2434	26	of	of	IN
cord-006229-7yoilsho	2434	27	an	an	DT
cord-006229-7yoilsho	2434	28	arrhythmogenic	arrhythmogenic	JJ
cord-006229-7yoilsho	2434	29	substrate	substrate	NN
cord-006229-7yoilsho	2434	30	in	in	IN
cord-006229-7yoilsho	2434	31	chronic	chronic	JJ
cord-006229-7yoilsho	2434	32	heart	heart	NN
cord-006229-7yoilsho	2434	33	disease	disease	NN
cord-006229-7yoilsho	2434	34	.	.	.
cord-006229-7yoilsho	2435	1	(	(	-LRB-
cord-006229-7yoilsho	2435	2	Chronic	chronic	JJ
cord-006229-7yoilsho	2435	3	overstimulation	overstimulation	NN
cord-006229-7yoilsho	2435	4	of	of	IN
cord-006229-7yoilsho	2435	5	cardiac	cardiac	JJ
cord-006229-7yoilsho	2435	6	β	β	NN
cord-006229-7yoilsho	2435	7	-	-	HYPH
cord-006229-7yoilsho	2435	8	adrenergic	adrenergic	JJ
cord-006229-7yoilsho	2435	9	receptors	receptor	NNS
cord-006229-7yoilsho	2435	10	(	(	-LRB-
cord-006229-7yoilsho	2435	11	β	β	NNP
cord-006229-7yoilsho	2435	12	-	-	HYPH
cord-006229-7yoilsho	2435	13	AR	AR	NNP
cord-006229-7yoilsho	2435	14	)	)	-RRB-
cord-006229-7yoilsho	2435	15	is	be	VBZ
cord-006229-7yoilsho	2435	16	a	a	DT
cord-006229-7yoilsho	2435	17	major	major	JJ
cord-006229-7yoilsho	2435	18	trigger	trigger	NN
cord-006229-7yoilsho	2435	19	for	for	IN
cord-006229-7yoilsho	2435	20	the	the	DT
cord-006229-7yoilsho	2435	21	development	development	NN
cord-006229-7yoilsho	2435	22	and	and	CC
cord-006229-7yoilsho	2435	23	maintenance	maintenance	NN
cord-006229-7yoilsho	2435	24	of	of	IN
cord-006229-7yoilsho	2435	25	cardiac	cardiac	JJ
cord-006229-7yoilsho	2435	26	hypertrophy	hypertrophy	NN
cord-006229-7yoilsho	2435	27	and	and	CC
cord-006229-7yoilsho	2435	28	heart	heart	NN
cord-006229-7yoilsho	2435	29	failure	failure	NN
cord-006229-7yoilsho	2435	30	.	.	.
cord-006229-7yoilsho	2436	1	Although	although	IN
cord-006229-7yoilsho	2436	2	the	the	DT
cord-006229-7yoilsho	2436	3	cAMP	camp	NN
cord-006229-7yoilsho	2436	4	activated	activate	VBD
cord-006229-7yoilsho	2436	5	proteinkinase	proteinkinase	NNP
cord-006229-7yoilsho	2436	6	A	A	NNP
cord-006229-7yoilsho	2436	7	(	(	-LRB-
cord-006229-7yoilsho	2436	8	PKA	PKA	NNP
cord-006229-7yoilsho	2436	9	)	)	-RRB-
cord-006229-7yoilsho	2436	10	is	be	VBZ
cord-006229-7yoilsho	2436	11	known	know	VBN
cord-006229-7yoilsho	2436	12	as	as	IN
cord-006229-7yoilsho	2436	13	a	a	DT
cord-006229-7yoilsho	2436	14	prominent	prominent	JJ
cord-006229-7yoilsho	2436	15	downstream	downstream	NN
cord-006229-7yoilsho	2436	16	effector	effector	NN
cord-006229-7yoilsho	2436	17	of	of	IN
cord-006229-7yoilsho	2436	18	β	β	NNP
cord-006229-7yoilsho	2436	19	-	-	HYPH
cord-006229-7yoilsho	2436	20	AR	AR	NNP
cord-006229-7yoilsho	2436	21	signaling	signaling	NN
cord-006229-7yoilsho	2436	22	,	,	,
cord-006229-7yoilsho	2436	23	its	-PRON-	PRP$
cord-006229-7yoilsho	2436	24	functional	functional	JJ
cord-006229-7yoilsho	2436	25	contribution	contribution	NN
cord-006229-7yoilsho	2436	26	to	to	IN
cord-006229-7yoilsho	2436	27	pathological	pathological	JJ
cord-006229-7yoilsho	2436	28	cardiac	cardiac	JJ
cord-006229-7yoilsho	2436	29	remodeling	remodeling	NN
cord-006229-7yoilsho	2436	30	is	be	VBZ
cord-006229-7yoilsho	2436	31	neither	neither	DT
cord-006229-7yoilsho	2436	32	well	well	RB
cord-006229-7yoilsho	2436	33	understood	understand	VBN
cord-006229-7yoilsho	2436	34	nor	nor	CC
cord-006229-7yoilsho	2436	35	directly	directly	RB
cord-006229-7yoilsho	2436	36	studied	study	VBN
cord-006229-7yoilsho	2436	37	so	so	RB
cord-006229-7yoilsho	2436	38	far	far	RB
cord-006229-7yoilsho	2436	39	.	.	.
cord-006229-7yoilsho	2437	1	To	to	TO
cord-006229-7yoilsho	2437	2	address	address	VB
cord-006229-7yoilsho	2437	3	this	this	DT
cord-006229-7yoilsho	2437	4	issue	issue	NN
cord-006229-7yoilsho	2437	5	we	-PRON-	PRP
cord-006229-7yoilsho	2437	6	used	use	VBD
cord-006229-7yoilsho	2437	7	mice	mouse	NNS
cord-006229-7yoilsho	2437	8	carrying	carry	VBG
cord-006229-7yoilsho	2437	9	a	a	DT
cord-006229-7yoilsho	2437	10	point	point	NN
cord-006229-7yoilsho	2437	11	mutation	mutation	NN
cord-006229-7yoilsho	2437	12	in	in	IN
cord-006229-7yoilsho	2437	13	the	the	DT
cord-006229-7yoilsho	2437	14	regulatory	regulatory	JJ
cord-006229-7yoilsho	2437	15	PKA	PKA	NNP
cord-006229-7yoilsho	2437	16	subunit	subunit	NN
cord-006229-7yoilsho	2437	17	RIα	RIα	NNS
cord-006229-7yoilsho	2437	18	(	(	-LRB-
cord-006229-7yoilsho	2437	19	PKARIαB	PKARIαB	NNP
cord-006229-7yoilsho	2437	20	)	)	-RRB-
cord-006229-7yoilsho	2437	21	,	,	,
cord-006229-7yoilsho	2437	22	which	which	WDT
cord-006229-7yoilsho	2437	23	prevents	prevent	VBZ
cord-006229-7yoilsho	2437	24	binding	binding	NN
cord-006229-7yoilsho	2437	25	of	of	IN
cord-006229-7yoilsho	2437	26	cAMP	camp	NN
cord-006229-7yoilsho	2437	27	and	and	CC
cord-006229-7yoilsho	2437	28	consequently	consequently	RB
cord-006229-7yoilsho	2437	29	diminished	diminish	VBD
cord-006229-7yoilsho	2437	30	kinase	kinase	NN
cord-006229-7yoilsho	2437	31	activity	activity	NN
cord-006229-7yoilsho	2437	32	.	.	.
cord-006229-7yoilsho	2438	1	This	this	DT
cord-006229-7yoilsho	2438	2	dominant	dominant	JJ
cord-006229-7yoilsho	2438	3	negative	negative	JJ
cord-006229-7yoilsho	2438	4	mutation	mutation	NN
cord-006229-7yoilsho	2438	5	was	be	VBD
cord-006229-7yoilsho	2438	6	controlled	control	VBN
cord-006229-7yoilsho	2438	7	by	by	IN
cord-006229-7yoilsho	2438	8	a	a	DT
cord-006229-7yoilsho	2438	9	tamoxifen	tamoxifen	NNP
cord-006229-7yoilsho	2438	10	(	(	-LRB-
cord-006229-7yoilsho	2438	11	tam	tam	NNP
cord-006229-7yoilsho	2438	12	)	)	-RRB-
cord-006229-7yoilsho	2438	13	inducible	inducible	JJ
cord-006229-7yoilsho	2438	14	αMHC	αmhc	NN
cord-006229-7yoilsho	2438	15	promotor	promotor	NN
cord-006229-7yoilsho	2438	16	driven	drive	VBN
cord-006229-7yoilsho	2438	17	Cre	Cre	NNP
cord-006229-7yoilsho	2438	18	transgene	transgene	NN
cord-006229-7yoilsho	2438	19	which	which	WDT
cord-006229-7yoilsho	2438	20	allows	allow	VBZ
cord-006229-7yoilsho	2438	21	a	a	DT
cord-006229-7yoilsho	2438	22	selective	selective	JJ
cord-006229-7yoilsho	2438	23	expression	expression	NN
cord-006229-7yoilsho	2438	24	in	in	IN
cord-006229-7yoilsho	2438	25	the	the	DT
cord-006229-7yoilsho	2438	26	ventricular	ventricular	JJ
cord-006229-7yoilsho	2438	27	myocardium	myocardium	NN
cord-006229-7yoilsho	2438	28	.	.	.
cord-006229-7yoilsho	2439	1	The	the	DT
cord-006229-7yoilsho	2439	2	inducible	inducible	JJ
cord-006229-7yoilsho	2439	3	and	and	CC
cord-006229-7yoilsho	2439	4	tissue	tissue	VB
cord-006229-7yoilsho	2439	5	specific	specific	JJ
cord-006229-7yoilsho	2439	6	gene	gene	NN
cord-006229-7yoilsho	2439	7	expression	expression	NN
cord-006229-7yoilsho	2439	8	was	be	VBD
cord-006229-7yoilsho	2439	9	analyzed	analyze	VBN
cord-006229-7yoilsho	2439	10	and	and	CC
cord-006229-7yoilsho	2439	11	confirmed	confirm	VBN
cord-006229-7yoilsho	2439	12	by	by	IN
cord-006229-7yoilsho	2439	13	PCR	PCR	NNP
cord-006229-7yoilsho	2439	14	,	,	,
cord-006229-7yoilsho	2439	15	RT	RT	NNP
cord-006229-7yoilsho	2439	16	-	-	HYPH
cord-006229-7yoilsho	2439	17	PCR	PCR	NNP
cord-006229-7yoilsho	2439	18	and	and	CC
cord-006229-7yoilsho	2439	19	immunohistochemistry	immunohistochemistry	NN
cord-006229-7yoilsho	2439	20	.	.	.
cord-006229-7yoilsho	2440	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	2440	2	diminished	diminish	VBD
cord-006229-7yoilsho	2440	3	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	2440	4	of	of	IN
cord-006229-7yoilsho	2440	5	several	several	JJ
cord-006229-7yoilsho	2440	6	PKA	PKA	NNP
cord-006229-7yoilsho	2440	7	targets	target	NNS
cord-006229-7yoilsho	2440	8	verifies	verify	VBZ
cord-006229-7yoilsho	2440	9	impaired	impair	VBN
cord-006229-7yoilsho	2440	10	PKA	PKA	NNP
cord-006229-7yoilsho	2440	11	activity	activity	NN
cord-006229-7yoilsho	2440	12	in	in	IN
cord-006229-7yoilsho	2440	13	tam	tam	NNP
cord-006229-7yoilsho	2440	14	treated	treat	VBD
cord-006229-7yoilsho	2440	15	double	double	JJ
cord-006229-7yoilsho	2440	16	transgenic	transgenic	JJ
cord-006229-7yoilsho	2440	17	animals	animal	NNS
cord-006229-7yoilsho	2440	18	.	.	.
cord-006229-7yoilsho	2441	1	Hypertrophic	hypertrophic	JJ
cord-006229-7yoilsho	2441	2	response	response	NN
cord-006229-7yoilsho	2441	3	in	in	IN
cord-006229-7yoilsho	2441	4	ventricular	ventricular	JJ
cord-006229-7yoilsho	2441	5	PKA	PKA	NNP
cord-006229-7yoilsho	2441	6	mutants	mutant	NNS
cord-006229-7yoilsho	2441	7	was	be	VBD
cord-006229-7yoilsho	2441	8	studied	study	VBN
cord-006229-7yoilsho	2441	9	in	in	IN
cord-006229-7yoilsho	2441	10	genetic	genetic	JJ
cord-006229-7yoilsho	2441	11	,	,	,
cord-006229-7yoilsho	2441	12	pharmacological	pharmacological	JJ
cord-006229-7yoilsho	2441	13	and	and	CC
cord-006229-7yoilsho	2441	14	surgical	surgical	JJ
cord-006229-7yoilsho	2441	15	mouse	mouse	NN
cord-006229-7yoilsho	2441	16	models	model	NNS
cord-006229-7yoilsho	2441	17	of	of	IN
cord-006229-7yoilsho	2441	18	heart	heart	NN
cord-006229-7yoilsho	2441	19	disease	disease	NN
cord-006229-7yoilsho	2441	20	as	as	RB
cord-006229-7yoilsho	2441	21	well	well	RB
cord-006229-7yoilsho	2441	22	.	.	.
cord-006229-7yoilsho	2442	1	Genetically	genetically	RB
cord-006229-7yoilsho	2442	2	induced	induce	VBN
cord-006229-7yoilsho	2442	3	heart	heart	NN
cord-006229-7yoilsho	2442	4	failure	failure	NN
cord-006229-7yoilsho	2442	5	was	be	VBD
cord-006229-7yoilsho	2442	6	observed	observe	VBN
cord-006229-7yoilsho	2442	7	following	follow	VBG
cord-006229-7yoilsho	2442	8	tam	tam	NNP
cord-006229-7yoilsho	2442	9	treatment	treatment	NN
cord-006229-7yoilsho	2442	10	in	in	IN
cord-006229-7yoilsho	2442	11	mice	mouse	NNS
cord-006229-7yoilsho	2442	12	expressing	express	VBG
cord-006229-7yoilsho	2442	13	an	an	DT
cord-006229-7yoilsho	2442	14	inducible	inducible	JJ
cord-006229-7yoilsho	2442	15	myocardial	myocardial	JJ
cord-006229-7yoilsho	2442	16	-	-	HYPH
cord-006229-7yoilsho	2442	17	specific	specific	JJ
cord-006229-7yoilsho	2442	18	Cre	Cre	NNP
cord-006229-7yoilsho	2442	19	transgene	transgene	NN
cord-006229-7yoilsho	2442	20	.	.	.
cord-006229-7yoilsho	2443	1	This	this	DT
cord-006229-7yoilsho	2443	2	deleterious	deleterious	JJ
cord-006229-7yoilsho	2443	3	cardiac	cardiac	JJ
cord-006229-7yoilsho	2443	4	phenotype	phenotype	NN
cord-006229-7yoilsho	2443	5	develops	develop	VBZ
cord-006229-7yoilsho	2443	6	independently	independently	RB
cord-006229-7yoilsho	2443	7	of	of	IN
cord-006229-7yoilsho	2443	8	the	the	DT
cord-006229-7yoilsho	2443	9	presence	presence	NN
cord-006229-7yoilsho	2443	10	of	of	IN
cord-006229-7yoilsho	2443	11	the	the	DT
cord-006229-7yoilsho	2443	12	floxed	floxe	VBN
cord-006229-7yoilsho	2443	13	transgene	transgene	NN
cord-006229-7yoilsho	2443	14	.	.	.
cord-006229-7yoilsho	2444	1	8	8	CD
cord-006229-7yoilsho	2444	2	days	day	NNS
cord-006229-7yoilsho	2444	3	after	after	IN
cord-006229-7yoilsho	2444	4	tam	tam	NNP
cord-006229-7yoilsho	2444	5	treatment	treatment	NNP
cord-006229-7yoilsho	2444	6	,	,	,
cord-006229-7yoilsho	2444	7	controls	control	NNS
cord-006229-7yoilsho	2444	8	displayed	display	VBD
cord-006229-7yoilsho	2444	9	elevated	elevated	JJ
cord-006229-7yoilsho	2444	10	heart	heart	NN
cord-006229-7yoilsho	2444	11	weight	weight	NN
cord-006229-7yoilsho	2444	12	to	to	TO
cord-006229-7yoilsho	2444	13	bodyweight	bodyweight	NN
cord-006229-7yoilsho	2444	14	ratio	ratio	NN
cord-006229-7yoilsho	2444	15	(	(	-LRB-
cord-006229-7yoilsho	2444	16	HBR	HBR	NNP
cord-006229-7yoilsho	2444	17	)	)	-RRB-
cord-006229-7yoilsho	2444	18	and	and	CC
cord-006229-7yoilsho	2444	19	heart	heart	NN
cord-006229-7yoilsho	2444	20	weight	weight	NN
cord-006229-7yoilsho	2444	21	to	to	IN
cord-006229-7yoilsho	2444	22	tibia	tibia	NN
cord-006229-7yoilsho	2444	23	length	length	NN
cord-006229-7yoilsho	2444	24	(	(	-LRB-
cord-006229-7yoilsho	2444	25	HTR	HTR	NNP
cord-006229-7yoilsho	2444	26	)	)	-RRB-
cord-006229-7yoilsho	2444	27	.	.	.
cord-006229-7yoilsho	2445	1	HBR	HBR	NNP
cord-006229-7yoilsho	2445	2	shifted	shift	VBD
cord-006229-7yoilsho	2445	3	from	from	IN
cord-006229-7yoilsho	2445	4	6.2(mg	6.2(mg	CD
cord-006229-7yoilsho	2445	5	/	/	SYM
cord-006229-7yoilsho	2445	6	g	g	NN
cord-006229-7yoilsho	2445	7	)	)	-RRB-
cord-006229-7yoilsho	2445	8	in	in	IN
cord-006229-7yoilsho	2445	9	untreated	untreated	JJ
cord-006229-7yoilsho	2445	10	control	control	NN
cord-006229-7yoilsho	2445	11	animals	animal	NNS
cord-006229-7yoilsho	2445	12	to	to	IN
cord-006229-7yoilsho	2445	13	10.9(mg	10.9(mg	CD
cord-006229-7yoilsho	2445	14	/	/	SYM
cord-006229-7yoilsho	2445	15	g	g	NN
cord-006229-7yoilsho	2445	16	)	)	-RRB-
cord-006229-7yoilsho	2445	17	in	in	IN
cord-006229-7yoilsho	2445	18	tam	tam	NNP
cord-006229-7yoilsho	2445	19	injected	inject	VBD
cord-006229-7yoilsho	2445	20	mice	mouse	NNS
cord-006229-7yoilsho	2445	21	.	.	.
cord-006229-7yoilsho	2446	1	In	in	IN
cord-006229-7yoilsho	2446	2	contrast	contrast	NN
cord-006229-7yoilsho	2446	3	PKA	PKA	NNP
cord-006229-7yoilsho	2446	4	inhibited	inhibit	VBN
cord-006229-7yoilsho	2446	5	mutants	mutant	NNS
cord-006229-7yoilsho	2446	6	displayed	display	VBD
cord-006229-7yoilsho	2446	7	a	a	DT
cord-006229-7yoilsho	2446	8	minor	minor	JJ
cord-006229-7yoilsho	2446	9	increased	increase	VBN
cord-006229-7yoilsho	2446	10	HBR	HBR	NNP
cord-006229-7yoilsho	2446	11	of	of	IN
cord-006229-7yoilsho	2446	12	7.7	7.7	CD
cord-006229-7yoilsho	2446	13	(	(	-LRB-
cord-006229-7yoilsho	2446	14	mg	mg	NN
cord-006229-7yoilsho	2446	15	/	/	SYM
cord-006229-7yoilsho	2446	16	g	g	NN
cord-006229-7yoilsho	2446	17	)	)	-RRB-
cord-006229-7yoilsho	2446	18	.	.	.
cord-006229-7yoilsho	2447	1	For	for	IN
cord-006229-7yoilsho	2447	2	the	the	DT
cord-006229-7yoilsho	2447	3	pharmacological	pharmacological	JJ
cord-006229-7yoilsho	2447	4	induction	induction	NN
cord-006229-7yoilsho	2447	5	of	of	IN
cord-006229-7yoilsho	2447	6	cardiac	cardiac	JJ
cord-006229-7yoilsho	2447	7	hypertrophy	hypertrophy	NN
cord-006229-7yoilsho	2447	8	we	-PRON-	PRP
cord-006229-7yoilsho	2447	9	implanted	implant	VBD
cord-006229-7yoilsho	2447	10	osmotic	osmotic	JJ
cord-006229-7yoilsho	2447	11	mini	mini	NN
cord-006229-7yoilsho	2447	12	pumps	pump	NNS
cord-006229-7yoilsho	2447	13	,	,	,
cord-006229-7yoilsho	2447	14	delivering	deliver	VBG
cord-006229-7yoilsho	2447	15	a	a	DT
cord-006229-7yoilsho	2447	16	combination	combination	NN
cord-006229-7yoilsho	2447	17	of	of	IN
cord-006229-7yoilsho	2447	18	isoproterenol	isoproterenol	NN
cord-006229-7yoilsho	2447	19	and	and	CC
cord-006229-7yoilsho	2447	20	phenylephrine	phenylephrine	NN
cord-006229-7yoilsho	2447	21	.	.	.
cord-006229-7yoilsho	2448	1	Control	control	NN
cord-006229-7yoilsho	2448	2	animals	animal	NNS
cord-006229-7yoilsho	2448	3	showed	show	VBD
cord-006229-7yoilsho	2448	4	a	a	DT
cord-006229-7yoilsho	2448	5	significantly	significantly	RB
cord-006229-7yoilsho	2448	6	increased	increase	VBN
cord-006229-7yoilsho	2448	7	HBR	HBR	NNP
cord-006229-7yoilsho	2448	8	(	(	-LRB-
cord-006229-7yoilsho	2448	9	8.4	8.4	CD
cord-006229-7yoilsho	2448	10	mg	mg	NNP
cord-006229-7yoilsho	2448	11	/	/	SYM
cord-006229-7yoilsho	2448	12	g	g	NN
cord-006229-7yoilsho	2448	13	)	)	-RRB-
cord-006229-7yoilsho	2448	14	compared	compare	VBN
cord-006229-7yoilsho	2448	15	to	to	IN
cord-006229-7yoilsho	2448	16	saline	saline	VB
cord-006229-7yoilsho	2448	17	treated	treat	VBN
cord-006229-7yoilsho	2448	18	animals	animal	NNS
cord-006229-7yoilsho	2448	19	(	(	-LRB-
cord-006229-7yoilsho	2448	20	6.8mg	6.8mg	CD
cord-006229-7yoilsho	2448	21	/	/	SYM
cord-006229-7yoilsho	2448	22	g	g	NN
cord-006229-7yoilsho	2448	23	)	)	-RRB-
cord-006229-7yoilsho	2448	24	and	and	CC
cord-006229-7yoilsho	2448	25	PKA	PKA	NNP
cord-006229-7yoilsho	2448	26	mutants	mutant	NNS
cord-006229-7yoilsho	2448	27	(	(	-LRB-
cord-006229-7yoilsho	2448	28	7.1	7.1	CD
cord-006229-7yoilsho	2448	29	mg	mg	NNP
cord-006229-7yoilsho	2448	30	/	/	SYM
cord-006229-7yoilsho	2448	31	g	g	NN
cord-006229-7yoilsho	2448	32	)	)	-RRB-
cord-006229-7yoilsho	2448	33	.	.	.
cord-006229-7yoilsho	2449	1	Paradoxically	paradoxically	RB
cord-006229-7yoilsho	2449	2	,	,	,
cord-006229-7yoilsho	2449	3	all	all	DT
cord-006229-7yoilsho	2449	4	PKA	PKA	NNP
cord-006229-7yoilsho	2449	5	inhibited	inhibited	JJ
cord-006229-7yoilsho	2449	6	animals	animal	NNS
cord-006229-7yoilsho	2449	7	displayed	display	VBD
cord-006229-7yoilsho	2449	8	a	a	DT
cord-006229-7yoilsho	2449	9	consistent	consistent	JJ
cord-006229-7yoilsho	2449	10	elevation	elevation	NN
cord-006229-7yoilsho	2449	11	in	in	IN
cord-006229-7yoilsho	2449	12	important	important	JJ
cord-006229-7yoilsho	2449	13	hypertrophic	hypertrophic	JJ
cord-006229-7yoilsho	2449	14	markers	marker	NNS
cord-006229-7yoilsho	2449	15	like	like	IN
cord-006229-7yoilsho	2449	16	ANP	ANP	NNP
cord-006229-7yoilsho	2449	17	.	.	.
cord-006229-7yoilsho	2450	1	Surgical	surgical	JJ
cord-006229-7yoilsho	2450	2	constriction	constriction	NN
cord-006229-7yoilsho	2450	3	of	of	IN
cord-006229-7yoilsho	2450	4	the	the	DT
cord-006229-7yoilsho	2450	5	aortic	aortic	JJ
cord-006229-7yoilsho	2450	6	arch	arch	NN
cord-006229-7yoilsho	2450	7	(	(	-LRB-
cord-006229-7yoilsho	2450	8	transverse	transverse	JJ
cord-006229-7yoilsho	2450	9	aortic	aortic	JJ
cord-006229-7yoilsho	2450	10	constriction	constriction	NN
cord-006229-7yoilsho	2450	11	TAC	TAC	NNP
cord-006229-7yoilsho	2450	12	)	)	-RRB-
cord-006229-7yoilsho	2450	13	led	lead	VBD
cord-006229-7yoilsho	2450	14	to	to	IN
cord-006229-7yoilsho	2450	15	a	a	DT
cord-006229-7yoilsho	2450	16	pressure	pressure	NN
cord-006229-7yoilsho	2450	17	induced	induce	VBN
cord-006229-7yoilsho	2450	18	hypertrophic	hypertrophic	JJ
cord-006229-7yoilsho	2450	19	response	response	NN
cord-006229-7yoilsho	2450	20	(	(	-LRB-
cord-006229-7yoilsho	2450	21	HBR	HBR	NNP
cord-006229-7yoilsho	2450	22	:	:	:
cord-006229-7yoilsho	2450	23	6.5	6.5	CD
cord-006229-7yoilsho	2450	24	vs	vs	IN
cord-006229-7yoilsho	2450	25	7.9	7.9	CD
cord-006229-7yoilsho	2450	26	mg	mg	NNP
cord-006229-7yoilsho	2450	27	/	/	SYM
cord-006229-7yoilsho	2450	28	g	g	NN
cord-006229-7yoilsho	2450	29	)	)	-RRB-
cord-006229-7yoilsho	2450	30	followed	follow	VBN
cord-006229-7yoilsho	2450	31	by	by	IN
cord-006229-7yoilsho	2450	32	a	a	DT
cord-006229-7yoilsho	2450	33	pronounced	pronounce	VBN
cord-006229-7yoilsho	2450	34	elevation	elevation	NN
cord-006229-7yoilsho	2450	35	in	in	IN
cord-006229-7yoilsho	2450	36	several	several	JJ
cord-006229-7yoilsho	2450	37	hypertrophic	hypertrophic	JJ
cord-006229-7yoilsho	2450	38	factors	factor	NNS
cord-006229-7yoilsho	2450	39	such	such	JJ
cord-006229-7yoilsho	2450	40	as	as	IN
cord-006229-7yoilsho	2450	41	ANP	ANP	NNP
cord-006229-7yoilsho	2450	42	,	,	,
cord-006229-7yoilsho	2450	43	Myh6/7	Myh6/7	NNP
cord-006229-7yoilsho	2450	44	ratio	ratio	NN
cord-006229-7yoilsho	2450	45	and	and	CC
cord-006229-7yoilsho	2450	46	myocytes	myocytes	NN
cord-006229-7yoilsho	2450	47	size	size	NN
cord-006229-7yoilsho	2450	48	.	.	.
cord-006229-7yoilsho	2451	1	In	in	IN
cord-006229-7yoilsho	2451	2	contrast	contrast	NN
cord-006229-7yoilsho	2451	3	PKA	PKA	NNP
cord-006229-7yoilsho	2451	4	mutants	mutant	NNS
cord-006229-7yoilsho	2451	5	displayed	display	VBD
cord-006229-7yoilsho	2451	6	an	an	DT
cord-006229-7yoilsho	2451	7	irregular	irregular	JJ
cord-006229-7yoilsho	2451	8	progression	progression	NN
cord-006229-7yoilsho	2451	9	of	of	IN
cord-006229-7yoilsho	2451	10	cardiac	cardiac	JJ
cord-006229-7yoilsho	2451	11	hypertrophy	hypertrophy	NN
cord-006229-7yoilsho	2451	12	presented	present	VBN
cord-006229-7yoilsho	2451	13	by	by	IN
cord-006229-7yoilsho	2451	14	two	two	CD
cord-006229-7yoilsho	2451	15	groups	group	NNS
cord-006229-7yoilsho	2451	16	with	with	IN
cord-006229-7yoilsho	2451	17	either	either	CC
cord-006229-7yoilsho	2451	18	an	an	DT
cord-006229-7yoilsho	2451	19	unchanged	unchanged	JJ
cord-006229-7yoilsho	2451	20	(	(	-LRB-
cord-006229-7yoilsho	2451	21	6.9	6.9	CD
cord-006229-7yoilsho	2451	22	mg	mg	NNP
cord-006229-7yoilsho	2451	23	/	/	SYM
cord-006229-7yoilsho	2451	24	g	g	NNP
cord-006229-7yoilsho	2451	25	)	)	-RRB-
cord-006229-7yoilsho	2451	26	or	or	CC
cord-006229-7yoilsho	2451	27	a	a	DT
cord-006229-7yoilsho	2451	28	strongly	strongly	RB
cord-006229-7yoilsho	2451	29	elevated	elevate	VBN
cord-006229-7yoilsho	2451	30	HBR	HBR	NNP
cord-006229-7yoilsho	2451	31	(	(	-LRB-
cord-006229-7yoilsho	2451	32	13.5	13.5	CD
cord-006229-7yoilsho	2451	33	mg	mg	NNP
cord-006229-7yoilsho	2451	34	/	/	SYM
cord-006229-7yoilsho	2451	35	g	g	NN
cord-006229-7yoilsho	2451	36	)	)	-RRB-
cord-006229-7yoilsho	2451	37	.	.	.
cord-006229-7yoilsho	2452	1	However	however	RB
cord-006229-7yoilsho	2452	2	,	,	,
cord-006229-7yoilsho	2452	3	additional	additional	JJ
cord-006229-7yoilsho	2452	4	hypertrophic	hypertrophic	JJ
cord-006229-7yoilsho	2452	5	factors	factor	NNS
cord-006229-7yoilsho	2452	6	including	include	VBG
cord-006229-7yoilsho	2452	7	ANP	ANP	NNP
cord-006229-7yoilsho	2452	8	,	,	,
cord-006229-7yoilsho	2452	9	Myh6/7	Myh6/7	NNP
cord-006229-7yoilsho	2452	10	ratio	ratio	NN
cord-006229-7yoilsho	2452	11	and	and	CC
cord-006229-7yoilsho	2452	12	myocyte	myocyte	NN
cord-006229-7yoilsho	2452	13	size	size	NN
cord-006229-7yoilsho	2452	14	were	be	VBD
cord-006229-7yoilsho	2452	15	significantly	significantly	RB
cord-006229-7yoilsho	2452	16	increased	increase	VBN
cord-006229-7yoilsho	2452	17	in	in	IN
cord-006229-7yoilsho	2452	18	both	both	DT
cord-006229-7yoilsho	2452	19	groups	group	NNS
cord-006229-7yoilsho	2452	20	.	.	.
cord-006229-7yoilsho	2453	1	To	to	IN
cord-006229-7yoilsho	2453	2	our	-PRON-	PRP$
cord-006229-7yoilsho	2453	3	knowledge	knowledge	NN
cord-006229-7yoilsho	2453	4	this	this	DT
cord-006229-7yoilsho	2453	5	is	be	VBZ
cord-006229-7yoilsho	2453	6	the	the	DT
cord-006229-7yoilsho	2453	7	first	first	JJ
cord-006229-7yoilsho	2453	8	report	report	NN
cord-006229-7yoilsho	2453	9	,	,	,
cord-006229-7yoilsho	2453	10	which	which	WDT
cord-006229-7yoilsho	2453	11	directly	directly	RB
cord-006229-7yoilsho	2453	12	studies	study	VBZ
cord-006229-7yoilsho	2453	13	the	the	DT
cord-006229-7yoilsho	2453	14	role	role	NN
cord-006229-7yoilsho	2453	15	of	of	IN
cord-006229-7yoilsho	2453	16	ventricular	ventricular	JJ
cord-006229-7yoilsho	2453	17	PKA	PKA	NNP
cord-006229-7yoilsho	2453	18	activity	activity	NN
cord-006229-7yoilsho	2453	19	in	in	IN
cord-006229-7yoilsho	2453	20	cardiac	cardiac	JJ
cord-006229-7yoilsho	2453	21	hypertrophy	hypertrophy	NN
cord-006229-7yoilsho	2453	22	in	in	IN
cord-006229-7yoilsho	2453	23	a	a	DT
cord-006229-7yoilsho	2453	24	genetically	genetically	RB
cord-006229-7yoilsho	2453	25	altered	alter	VBN
cord-006229-7yoilsho	2453	26	mouse	mouse	NN
cord-006229-7yoilsho	2453	27	model	model	NN
cord-006229-7yoilsho	2453	28	.	.	.
cord-006229-7yoilsho	2454	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	2454	2	results	result	NNS
cord-006229-7yoilsho	2454	3	suggest	suggest	VBP
cord-006229-7yoilsho	2454	4	that	that	IN
cord-006229-7yoilsho	2454	5	in	in	IN
cord-006229-7yoilsho	2454	6	an	an	DT
cord-006229-7yoilsho	2454	7	early	early	JJ
cord-006229-7yoilsho	2454	8	stage	stage	NN
cord-006229-7yoilsho	2454	9	of	of	IN
cord-006229-7yoilsho	2454	10	cardiac	cardiac	JJ
cord-006229-7yoilsho	2454	11	remodeling	remodeling	NN
cord-006229-7yoilsho	2454	12	PKA	PKA	NNP
cord-006229-7yoilsho	2454	13	inhibition	inhibition	NN
cord-006229-7yoilsho	2454	14	alleviates	alleviate	VBZ
cord-006229-7yoilsho	2454	15	cardiac	cardiac	JJ
cord-006229-7yoilsho	2454	16	weight	weight	NN
cord-006229-7yoilsho	2454	17	gain	gain	NN
cord-006229-7yoilsho	2454	18	but	but	CC
cord-006229-7yoilsho	2454	19	provokes	provoke	VBZ
cord-006229-7yoilsho	2454	20	a	a	DT
cord-006229-7yoilsho	2454	21	detrimental	detrimental	JJ
cord-006229-7yoilsho	2454	22	shift	shift	NN
cord-006229-7yoilsho	2454	23	during	during	IN
cord-006229-7yoilsho	2454	24	further	further	JJ
cord-006229-7yoilsho	2454	25	progression	progression	NN
cord-006229-7yoilsho	2454	26	,	,	,
cord-006229-7yoilsho	2454	27	which	which	WDT
cord-006229-7yoilsho	2454	28	implicates	implicate	VBZ
cord-006229-7yoilsho	2454	29	a	a	DT
cord-006229-7yoilsho	2454	30	protective	protective	JJ
cord-006229-7yoilsho	2454	31	role	role	NN
cord-006229-7yoilsho	2454	32	of	of	IN
cord-006229-7yoilsho	2454	33	ventricular	ventricular	JJ
cord-006229-7yoilsho	2454	34	PKA	PKA	NNP
cord-006229-7yoilsho	2454	35	activity	activity	NN
cord-006229-7yoilsho	2454	36	in	in	IN
cord-006229-7yoilsho	2454	37	cardiac	cardiac	JJ
cord-006229-7yoilsho	2454	38	disease	disease	NN
cord-006229-7yoilsho	2454	39	.	.	.
cord-006229-7yoilsho	2455	1	Acetyl	Acetyl	NNP
cord-006229-7yoilsho	2455	2	-	-	HYPH
cord-006229-7yoilsho	2455	3	CoA	coa	NN
cord-006229-7yoilsho	2455	4	carboxylase	carboxylase	NN
cord-006229-7yoilsho	2455	5	catalyzes	catalyze	VBZ
cord-006229-7yoilsho	2455	6	the	the	DT
cord-006229-7yoilsho	2455	7	first	first	JJ
cord-006229-7yoilsho	2455	8	step	step	NN
cord-006229-7yoilsho	2455	9	in	in	IN
cord-006229-7yoilsho	2455	10	the	the	DT
cord-006229-7yoilsho	2455	11	biosynthesis	biosynthesis	NN
cord-006229-7yoilsho	2455	12	of	of	IN
cord-006229-7yoilsho	2455	13	fatty	fatty	JJ
cord-006229-7yoilsho	2455	14	acids	acid	NNS
cord-006229-7yoilsho	2455	15	in	in	IN
cord-006229-7yoilsho	2455	16	bacterial	bacterial	JJ
cord-006229-7yoilsho	2455	17	and	and	CC
cord-006229-7yoilsho	2455	18	eukaryotic	eukaryotic	JJ
cord-006229-7yoilsho	2455	19	cells	cell	NNS
cord-006229-7yoilsho	2455	20	,	,	,
cord-006229-7yoilsho	2455	21	i.e.	i.e.	FW
cord-006229-7yoilsho	2455	22	the	the	DT
cord-006229-7yoilsho	2455	23	conversion	conversion	NN
cord-006229-7yoilsho	2455	24	(	(	-LRB-
cord-006229-7yoilsho	2455	25	carboxylation	carboxylation	NN
cord-006229-7yoilsho	2455	26	)	)	-RRB-
cord-006229-7yoilsho	2455	27	of	of	IN
cord-006229-7yoilsho	2455	28	acetyl	acetyl	NN
cord-006229-7yoilsho	2455	29	-	-	HYPH
cord-006229-7yoilsho	2455	30	CoA	CoA	NNP
cord-006229-7yoilsho	2455	31	into	into	IN
cord-006229-7yoilsho	2455	32	malonyl	malonyl	NNP
cord-006229-7yoilsho	2455	33	-	-	HYPH
cord-006229-7yoilsho	2455	34	CoA.	CoA.	NNP
cord-006229-7yoilsho	2455	35	ACC	ACC	NNP
cord-006229-7yoilsho	2455	36	-	-	HYPH
cord-006229-7yoilsho	2455	37	generated	generate	VBN
cord-006229-7yoilsho	2455	38	malonyl	malonyl	NNP
cord-006229-7yoilsho	2455	39	-	-	HYPH
cord-006229-7yoilsho	2455	40	CoA	coa	NN
cord-006229-7yoilsho	2455	41	functions	function	NNS
cord-006229-7yoilsho	2455	42	as	as	IN
cord-006229-7yoilsho	2455	43	a	a	DT
cord-006229-7yoilsho	2455	44	substrate	substrate	NN
cord-006229-7yoilsho	2455	45	for	for	IN
cord-006229-7yoilsho	2455	46	de	de	FW
cord-006229-7yoilsho	2455	47	novo	novo	NNP
cord-006229-7yoilsho	2455	48	lipogenesis	lipogenesi	NNS
cord-006229-7yoilsho	2455	49	and	and	CC
cord-006229-7yoilsho	2455	50	acts	act	VBZ
cord-006229-7yoilsho	2455	51	as	as	IN
cord-006229-7yoilsho	2455	52	an	an	DT
cord-006229-7yoilsho	2455	53	inhibitor	inhibitor	NN
cord-006229-7yoilsho	2455	54	of	of	IN
cord-006229-7yoilsho	2455	55	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	2455	56	β	β	NN
cord-006229-7yoilsho	2455	57	-	-	HYPH
cord-006229-7yoilsho	2455	58	oxidation	oxidation	NN
cord-006229-7yoilsho	2455	59	of	of	IN
cord-006229-7yoilsho	2455	60	fatty	fatty	JJ
cord-006229-7yoilsho	2455	61	acids	acid	NNS
cord-006229-7yoilsho	2455	62	.	.	.
cord-006229-7yoilsho	2456	1	Because	because	IN
cord-006229-7yoilsho	2456	2	of	of	IN
cord-006229-7yoilsho	2456	3	its	-PRON-	PRP$
cord-006229-7yoilsho	2456	4	role	role	NN
cord-006229-7yoilsho	2456	5	in	in	IN
cord-006229-7yoilsho	2456	6	lipid	lipid	NN
cord-006229-7yoilsho	2456	7	metabolism	metabolism	NN
cord-006229-7yoilsho	2456	8	this	this	DT
cord-006229-7yoilsho	2456	9	enzyme	enzyme	NN
cord-006229-7yoilsho	2456	10	has	have	VBZ
cord-006229-7yoilsho	2456	11	become	become	VBN
cord-006229-7yoilsho	2456	12	an	an	DT
cord-006229-7yoilsho	2456	13	interesting	interesting	JJ
cord-006229-7yoilsho	2456	14	target	target	NN
cord-006229-7yoilsho	2456	15	in	in	IN
cord-006229-7yoilsho	2456	16	drug	drug	NN
cord-006229-7yoilsho	2456	17	discovery	discovery	NN
cord-006229-7yoilsho	2456	18	in	in	IN
cord-006229-7yoilsho	2456	19	the	the	DT
cord-006229-7yoilsho	2456	20	field	field	NN
cord-006229-7yoilsho	2456	21	of	of	IN
cord-006229-7yoilsho	2456	22	metabolic	metabolic	JJ
cord-006229-7yoilsho	2456	23	diseases	disease	NNS
cord-006229-7yoilsho	2456	24	and	and	CC
cord-006229-7yoilsho	2456	25	cancer	cancer	NN
cord-006229-7yoilsho	2456	26	.	.	.
cord-006229-7yoilsho	2457	1	Despite	despite	IN
cord-006229-7yoilsho	2457	2	this	this	DT
cord-006229-7yoilsho	2457	3	interest	interest	NN
cord-006229-7yoilsho	2457	4	in	in	IN
cord-006229-7yoilsho	2457	5	ACC	ACC	NNP
cord-006229-7yoilsho	2457	6	,	,	,
cord-006229-7yoilsho	2457	7	no	no	DT
cord-006229-7yoilsho	2457	8	attention	attention	NN
cord-006229-7yoilsho	2457	9	has	have	VBZ
cord-006229-7yoilsho	2457	10	as	as	RB
cord-006229-7yoilsho	2457	11	yet	yet	RB
cord-006229-7yoilsho	2457	12	been	be	VBN
cord-006229-7yoilsho	2457	13	given	give	VBN
cord-006229-7yoilsho	2457	14	to	to	IN
cord-006229-7yoilsho	2457	15	the	the	DT
cord-006229-7yoilsho	2457	16	role	role	NN
cord-006229-7yoilsho	2457	17	of	of	IN
cord-006229-7yoilsho	2457	18	ACC	ACC	NNP
cord-006229-7yoilsho	2457	19	in	in	IN
cord-006229-7yoilsho	2457	20	endothelial	endothelial	JJ
cord-006229-7yoilsho	2457	21	cells	cell	NNS
cord-006229-7yoilsho	2457	22	.	.	.
cord-006229-7yoilsho	2458	1	We	-PRON-	PRP
cord-006229-7yoilsho	2458	2	aimed	aim	VBD
cord-006229-7yoilsho	2458	3	to	to	TO
cord-006229-7yoilsho	2458	4	investigate	investigate	VB
cord-006229-7yoilsho	2458	5	the	the	DT
cord-006229-7yoilsho	2458	6	role	role	NN
cord-006229-7yoilsho	2458	7	of	of	IN
cord-006229-7yoilsho	2458	8	ACC	ACC	NNP
cord-006229-7yoilsho	2458	9	in	in	IN
cord-006229-7yoilsho	2458	10	two	two	CD
cord-006229-7yoilsho	2458	11	functional	functional	JJ
cord-006229-7yoilsho	2458	12	key	key	JJ
cord-006229-7yoilsho	2458	13	aspects	aspect	NNS
cord-006229-7yoilsho	2458	14	of	of	IN
cord-006229-7yoilsho	2458	15	angiogenesis	angiogenesis	NN
cord-006229-7yoilsho	2458	16	:	:	:
cord-006229-7yoilsho	2458	17	endothelial	endothelial	JJ
cord-006229-7yoilsho	2458	18	cell	cell	NN
cord-006229-7yoilsho	2458	19	proliferation	proliferation	NN
cord-006229-7yoilsho	2458	20	and	and	CC
cord-006229-7yoilsho	2458	21	migration	migration	NN
cord-006229-7yoilsho	2458	22	.	.	.
cord-006229-7yoilsho	2459	1	We	-PRON-	PRP
cord-006229-7yoilsho	2459	2	used	use	VBD
cord-006229-7yoilsho	2459	3	the	the	DT
cord-006229-7yoilsho	2459	4	ACC	ACC	NNP
cord-006229-7yoilsho	2459	5	inhibitor	inhibitor	NN
cord-006229-7yoilsho	2459	6	soraphen	soraphen	VBZ
cord-006229-7yoilsho	2459	7	A	A	NNP
cord-006229-7yoilsho	2459	8	,	,	,
cord-006229-7yoilsho	2459	9	a	a	DT
cord-006229-7yoilsho	2459	10	polyketidic	polyketidic	JJ
cord-006229-7yoilsho	2459	11	natural	natural	JJ
cord-006229-7yoilsho	2459	12	compound	compound	NN
cord-006229-7yoilsho	2459	13	isolated	isolate	VBN
cord-006229-7yoilsho	2459	14	from	from	IN
cord-006229-7yoilsho	2459	15	the	the	DT
cord-006229-7yoilsho	2459	16	myxobacterium	myxobacterium	NN
cord-006229-7yoilsho	2459	17	Sorangium	Sorangium	NNP
cord-006229-7yoilsho	2459	18	cellulosum	cellulosum	NN
cord-006229-7yoilsho	2459	19	,	,	,
cord-006229-7yoilsho	2459	20	as	as	RB
cord-006229-7yoilsho	2459	21	well	well	RB
cord-006229-7yoilsho	2459	22	as	as	IN
cord-006229-7yoilsho	2459	23	an	an	DT
cord-006229-7yoilsho	2459	24	RNAi	rnai	NN
cord-006229-7yoilsho	2459	25	-	-	HYPH
cord-006229-7yoilsho	2459	26	based	base	VBN
cord-006229-7yoilsho	2459	27	approach	approach	NN
cord-006229-7yoilsho	2459	28	to	to	TO
cord-006229-7yoilsho	2459	29	inhibit	inhibit	VB
cord-006229-7yoilsho	2459	30	the	the	DT
cord-006229-7yoilsho	2459	31	function	function	NN
cord-006229-7yoilsho	2459	32	of	of	IN
cord-006229-7yoilsho	2459	33	ACC	ACC	NNP
cord-006229-7yoilsho	2459	34	.	.	.
cord-006229-7yoilsho	2460	1	Primary	primary	JJ
cord-006229-7yoilsho	2460	2	human	human	JJ
cord-006229-7yoilsho	2460	3	umbilical	umbilical	JJ
cord-006229-7yoilsho	2460	4	vein	vein	NN
cord-006229-7yoilsho	2460	5	endothelial	endothelial	JJ
cord-006229-7yoilsho	2460	6	cells	cell	NNS
cord-006229-7yoilsho	2460	7	(	(	-LRB-
cord-006229-7yoilsho	2460	8	HUVECs	huvec	NNS
cord-006229-7yoilsho	2460	9	)	)	-RRB-
cord-006229-7yoilsho	2460	10	were	be	VBD
cord-006229-7yoilsho	2460	11	used	use	VBN
cord-006229-7yoilsho	2460	12	as	as	IN
cord-006229-7yoilsho	2460	13	in	in	IN
cord-006229-7yoilsho	2460	14	vitro	vitro	FW
cord-006229-7yoilsho	2460	15	model	model	NN
cord-006229-7yoilsho	2460	16	.	.	.
cord-006229-7yoilsho	2461	1	First	first	RB
cord-006229-7yoilsho	2461	2	,	,	,
cord-006229-7yoilsho	2461	3	we	-PRON-	PRP
cord-006229-7yoilsho	2461	4	analyzed	analyze	VBD
cord-006229-7yoilsho	2461	5	the	the	DT
cord-006229-7yoilsho	2461	6	action	action	NN
cord-006229-7yoilsho	2461	7	of	of	IN
cord-006229-7yoilsho	2461	8	soraphen	soraphen	NN
cord-006229-7yoilsho	2461	9	A	A	NNP
cord-006229-7yoilsho	2461	10	on	on	IN
cord-006229-7yoilsho	2461	11	cell	cell	NN
cord-006229-7yoilsho	2461	12	viability	viability	NN
cord-006229-7yoilsho	2461	13	.	.	.
cord-006229-7yoilsho	2462	1	The	the	DT
cord-006229-7yoilsho	2462	2	compound	compound	NN
cord-006229-7yoilsho	2462	3	did	do	VBD
cord-006229-7yoilsho	2462	4	neither	neither	CC
cord-006229-7yoilsho	2462	5	lower	lower	VB
cord-006229-7yoilsho	2462	6	the	the	DT
cord-006229-7yoilsho	2462	7	metabolic	metabolic	JJ
cord-006229-7yoilsho	2462	8	activity	activity	NN
cord-006229-7yoilsho	2462	9	of	of	IN
cord-006229-7yoilsho	2462	10	HUVECs	huvec	NNS
cord-006229-7yoilsho	2462	11	up	up	IN
cord-006229-7yoilsho	2462	12	to	to	IN
cord-006229-7yoilsho	2462	13	a	a	DT
cord-006229-7yoilsho	2462	14	concentration	concentration	NN
cord-006229-7yoilsho	2462	15	of	of	IN
cord-006229-7yoilsho	2462	16	100	100	CD
cord-006229-7yoilsho	2462	17	µM	µM	NFP
cord-006229-7yoilsho	2462	18	after	after	IN
cord-006229-7yoilsho	2462	19	24	24	CD
cord-006229-7yoilsho	2462	20	and	and	CC
cord-006229-7yoilsho	2462	21	48	48	CD
cord-006229-7yoilsho	2462	22	h	h	NN
cord-006229-7yoilsho	2462	23	(	(	-LRB-
cord-006229-7yoilsho	2462	24	CTB	CTB	NNP
cord-006229-7yoilsho	2462	25	assay	assay	NN
cord-006229-7yoilsho	2462	26	)	)	-RRB-
cord-006229-7yoilsho	2462	27	nor	nor	CC
cord-006229-7yoilsho	2462	28	increase	increase	VB
cord-006229-7yoilsho	2462	29	in	in	IN
cord-006229-7yoilsho	2462	30	the	the	DT
cord-006229-7yoilsho	2462	31	apoptosis	apoptosis	NN
cord-006229-7yoilsho	2462	32	rate	rate	NN
cord-006229-7yoilsho	2462	33	after	after	IN
cord-006229-7yoilsho	2462	34	24	24	CD
cord-006229-7yoilsho	2462	35	,	,	,
cord-006229-7yoilsho	2462	36	48	48	CD
cord-006229-7yoilsho	2462	37	,	,	,
cord-006229-7yoilsho	2462	38	or	or	CC
cord-006229-7yoilsho	2462	39	72	72	CD
cord-006229-7yoilsho	2462	40	h	h	NN
cord-006229-7yoilsho	2462	41	up	up	IN
cord-006229-7yoilsho	2462	42	to	to	IN
cord-006229-7yoilsho	2462	43	100	100	CD
cord-006229-7yoilsho	2463	1	µM.	µM.	NNP
cord-006229-7yoilsho	2463	2	Measuring	Measuring	NNP
cord-006229-7yoilsho	2463	3	adenosine	adenosine	NN
cord-006229-7yoilsho	2463	4	triphosphate	triphosphate	NN
cord-006229-7yoilsho	2463	5	(	(	-LRB-
cord-006229-7yoilsho	2463	6	ATP	ATP	NNP
cord-006229-7yoilsho	2463	7	)	)	-RRB-
cord-006229-7yoilsho	2463	8	levels	level	NNS
cord-006229-7yoilsho	2463	9	revealed	reveal	VBD
cord-006229-7yoilsho	2463	10	that	that	IN
cord-006229-7yoilsho	2463	11	30	30	CD
cord-006229-7yoilsho	2463	12	µM	µm	NN
cord-006229-7yoilsho	2463	13	soraphen	soraphen	NN
cord-006229-7yoilsho	2463	14	A	a	NN
cord-006229-7yoilsho	2463	15	does	do	VBZ
cord-006229-7yoilsho	2463	16	not	not	RB
cord-006229-7yoilsho	2463	17	alter	alter	VB
cord-006229-7yoilsho	2463	18	the	the	DT
cord-006229-7yoilsho	2463	19	ATP	ATP	NNP
cord-006229-7yoilsho	2463	20	levels	level	NNS
cord-006229-7yoilsho	2463	21	in	in	IN
cord-006229-7yoilsho	2463	22	HUVECs	huvec	NNS
cord-006229-7yoilsho	2463	23	after	after	IN
cord-006229-7yoilsho	2463	24	24	24	CD
cord-006229-7yoilsho	2463	25	h	h	NN
cord-006229-7yoilsho	2463	26	treatment	treatment	NN
cord-006229-7yoilsho	2463	27	.	.	.
cord-006229-7yoilsho	2464	1	In	in	IN
cord-006229-7yoilsho	2464	2	contrast	contrast	NN
cord-006229-7yoilsho	2464	3	,	,	,
cord-006229-7yoilsho	2464	4	a	a	DT
cord-006229-7yoilsho	2464	5	48	48	CD
cord-006229-7yoilsho	2464	6	h	h	NN
cord-006229-7yoilsho	2464	7	treatment	treatment	NN
cord-006229-7yoilsho	2464	8	significantly	significantly	RB
cord-006229-7yoilsho	2464	9	lowered	lower	VBD
cord-006229-7yoilsho	2464	10	the	the	DT
cord-006229-7yoilsho	2464	11	ATP	ATP	NNP
cord-006229-7yoilsho	2464	12	levels	level	NNS
cord-006229-7yoilsho	2464	13	by	by	IN
cord-006229-7yoilsho	2464	14	12	12	CD
cord-006229-7yoilsho	2464	15	%	%	NN
cord-006229-7yoilsho	2464	16	.	.	.
cord-006229-7yoilsho	2465	1	Also	also	RB
cord-006229-7yoilsho	2465	2	gene	gene	NN
cord-006229-7yoilsho	2465	3	silencing	silencing	NN
cord-006229-7yoilsho	2465	4	of	of	IN
cord-006229-7yoilsho	2465	5	ACC1	ACC1	NNP
cord-006229-7yoilsho	2465	6	in	in	IN
cord-006229-7yoilsho	2465	7	HUVECs	huvec	NNS
cord-006229-7yoilsho	2465	8	attenuated	attenuate	VBD
cord-006229-7yoilsho	2465	9	the	the	DT
cord-006229-7yoilsho	2465	10	ATP	ATP	NNP
cord-006229-7yoilsho	2465	11	levels	level	NNS
cord-006229-7yoilsho	2465	12	by	by	IN
cord-006229-7yoilsho	2465	13	11	11	CD
cord-006229-7yoilsho	2465	14	%	%	NN
cord-006229-7yoilsho	2465	15	.	.	.
cord-006229-7yoilsho	2466	1	Mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	2466	2	membrane	membrane	NN
cord-006229-7yoilsho	2466	3	potential	potential	NN
cord-006229-7yoilsho	2466	4	(	(	-LRB-
cord-006229-7yoilsho	2466	5	MMP	MMP	NNP
cord-006229-7yoilsho	2466	6	)	)	-RRB-
cord-006229-7yoilsho	2466	7	assays	assay	NNS
cord-006229-7yoilsho	2466	8	showed	show	VBD
cord-006229-7yoilsho	2466	9	decreased	decrease	VBD
cord-006229-7yoilsho	2466	10	MMP	MMP	NNP
cord-006229-7yoilsho	2466	11	levels	level	NNS
cord-006229-7yoilsho	2466	12	(	(	-LRB-
cord-006229-7yoilsho	2466	13	10	10	CD
cord-006229-7yoilsho	2466	14	%	%	NN
cord-006229-7yoilsho	2466	15	)	)	-RRB-
cord-006229-7yoilsho	2466	16	in	in	IN
cord-006229-7yoilsho	2466	17	soraphen	soraphen	NNP
cord-006229-7yoilsho	2466	18	A	A	NNP
cord-006229-7yoilsho	2466	19	-	-	HYPH
cord-006229-7yoilsho	2466	20	treated	treat	VBN
cord-006229-7yoilsho	2466	21	cells	cell	NNS
cord-006229-7yoilsho	2466	22	after	after	IN
cord-006229-7yoilsho	2466	23	24	24	CD
cord-006229-7yoilsho	2466	24	h.	h.	NN
cord-006229-7yoilsho	2467	1	Interestingly	interestingly	RB
cord-006229-7yoilsho	2467	2	,	,	,
cord-006229-7yoilsho	2467	3	the	the	DT
cord-006229-7yoilsho	2467	4	compound	compound	NN
cord-006229-7yoilsho	2467	5	inhibited	inhibit	VBD
cord-006229-7yoilsho	2467	6	the	the	DT
cord-006229-7yoilsho	2467	7	proliferation	proliferation	NN
cord-006229-7yoilsho	2467	8	of	of	IN
cord-006229-7yoilsho	2467	9	endothelial	endothelial	JJ
cord-006229-7yoilsho	2467	10	cells	cell	NNS
cord-006229-7yoilsho	2467	11	with	with	IN
cord-006229-7yoilsho	2467	12	an	an	DT
cord-006229-7yoilsho	2467	13	IC	IC	NNP
cord-006229-7yoilsho	2467	14	50	50	CD
cord-006229-7yoilsho	2467	15	value	value	NN
cord-006229-7yoilsho	2467	16	of	of	IN
cord-006229-7yoilsho	2467	17	34	34	CD
cord-006229-7yoilsho	2467	18	µM.	µm.	JJ
cord-006229-7yoilsho	2467	19	Cell	Cell	NNP
cord-006229-7yoilsho	2467	20	cycle	cycle	NN
cord-006229-7yoilsho	2467	21	analysis	analysis	NN
cord-006229-7yoilsho	2467	22	showed	show	VBD
cord-006229-7yoilsho	2467	23	that	that	IN
cord-006229-7yoilsho	2467	24	soraphen	soraphen	VBZ
cord-006229-7yoilsho	2467	25	A	a	DT
cord-006229-7yoilsho	2467	26	decreases	decrease	VBZ
cord-006229-7yoilsho	2467	27	the	the	DT
cord-006229-7yoilsho	2467	28	amount	amount	NN
cord-006229-7yoilsho	2467	29	of	of	IN
cord-006229-7yoilsho	2467	30	cells	cell	NNS
cord-006229-7yoilsho	2467	31	in	in	IN
cord-006229-7yoilsho	2467	32	the	the	DT
cord-006229-7yoilsho	2467	33	G	g	NN
cord-006229-7yoilsho	2467	34	0	0	CD
cord-006229-7yoilsho	2467	35	/G	/g	SYM
cord-006229-7yoilsho	2467	36	1	1	CD
cord-006229-7yoilsho	2467	37	phase	phase	NN
cord-006229-7yoilsho	2467	38	by	by	IN
cord-006229-7yoilsho	2467	39	26	26	CD
cord-006229-7yoilsho	2467	40	%	%	NN
cord-006229-7yoilsho	2467	41	and	and	CC
cord-006229-7yoilsho	2467	42	increases	increase	VBZ
cord-006229-7yoilsho	2467	43	the	the	DT
cord-006229-7yoilsho	2467	44	number	number	NN
cord-006229-7yoilsho	2467	45	of	of	IN
cord-006229-7yoilsho	2467	46	cells	cell	NNS
cord-006229-7yoilsho	2467	47	in	in	IN
cord-006229-7yoilsho	2467	48	the	the	DT
cord-006229-7yoilsho	2467	49	G	g	NN
cord-006229-7yoilsho	2467	50	2	2	CD
cord-006229-7yoilsho	2467	51	/M	/M	.
cord-006229-7yoilsho	2467	52	phase	phase	NN
cord-006229-7yoilsho	2467	53	by	by	IN
cord-006229-7yoilsho	2467	54	50	50	CD
cord-006229-7yoilsho	2467	55	%	%	NN
cord-006229-7yoilsho	2467	56	.	.	.
cord-006229-7yoilsho	2468	1	The	the	DT
cord-006229-7yoilsho	2468	2	compound	compound	NN
cord-006229-7yoilsho	2468	3	also	also	RB
cord-006229-7yoilsho	2468	4	inhibited	inhibit	VBD
cord-006229-7yoilsho	2468	5	the	the	DT
cord-006229-7yoilsho	2468	6	activation	activation	NN
cord-006229-7yoilsho	2468	7	of	of	IN
cord-006229-7yoilsho	2468	8	Akt	Akt	NNP
cord-006229-7yoilsho	2468	9	(	(	-LRB-
cord-006229-7yoilsho	2468	10	Western	western	JJ
cord-006229-7yoilsho	2468	11	blot	blot	NN
cord-006229-7yoilsho	2468	12	analysis	analysis	NN
cord-006229-7yoilsho	2468	13	)	)	-RRB-
cord-006229-7yoilsho	2468	14	.	.	.
cord-006229-7yoilsho	2469	1	In	in	IN
cord-006229-7yoilsho	2469	2	a	a	DT
cord-006229-7yoilsho	2469	3	wound	wound	NN
cord-006229-7yoilsho	2469	4	healing	healing	NN
cord-006229-7yoilsho	2469	5	/	/	SYM
cord-006229-7yoilsho	2469	6	scratch	scratch	NN
cord-006229-7yoilsho	2469	7	assay	assay	NN
cord-006229-7yoilsho	2469	8	,	,	,
cord-006229-7yoilsho	2469	9	30	30	CD
cord-006229-7yoilsho	2469	10	µM	µm	NN
cord-006229-7yoilsho	2469	11	soraphen	soraphen	NN
cord-006229-7yoilsho	2469	12	A	A	NNP
cord-006229-7yoilsho	2469	13	lowered	lower	VBD
cord-006229-7yoilsho	2469	14	the	the	DT
cord-006229-7yoilsho	2469	15	migration	migration	NN
cord-006229-7yoilsho	2469	16	of	of	IN
cord-006229-7yoilsho	2469	17	endothelial	endothelial	JJ
cord-006229-7yoilsho	2469	18	cells	cell	NNS
cord-006229-7yoilsho	2469	19	by	by	IN
cord-006229-7yoilsho	2469	20	65	65	CD
cord-006229-7yoilsho	2469	21	%	%	NN
cord-006229-7yoilsho	2469	22	.	.	.
cord-006229-7yoilsho	2470	1	Gene	gene	NN
cord-006229-7yoilsho	2470	2	silencing	silencing	NN
cord-006229-7yoilsho	2470	3	of	of	IN
cord-006229-7yoilsho	2470	4	ACC1	ACC1	NNP
cord-006229-7yoilsho	2470	5	in	in	IN
cord-006229-7yoilsho	2470	6	HUVECs	huvec	NNS
cord-006229-7yoilsho	2470	7	strongly	strongly	RB
cord-006229-7yoilsho	2470	8	decreased	decrease	VBD
cord-006229-7yoilsho	2470	9	endothelial	endothelial	JJ
cord-006229-7yoilsho	2470	10	migration	migration	NN
cord-006229-7yoilsho	2470	11	,	,	,
cord-006229-7yoilsho	2470	12	whereas	whereas	IN
cord-006229-7yoilsho	2470	13	a	a	DT
cord-006229-7yoilsho	2470	14	knockdown	knockdown	NN
cord-006229-7yoilsho	2470	15	of	of	IN
cord-006229-7yoilsho	2470	16	ACC2	ACC2	NNP
cord-006229-7yoilsho	2470	17	had	have	VBD
cord-006229-7yoilsho	2470	18	no	no	DT
cord-006229-7yoilsho	2470	19	influence	influence	NN
cord-006229-7yoilsho	2470	20	.	.	.
cord-006229-7yoilsho	2471	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	2471	2	,	,	,
cord-006229-7yoilsho	2471	3	Boyden	Boyden	NNP
cord-006229-7yoilsho	2471	4	chamber	chamber	NN
cord-006229-7yoilsho	2471	5	assays	assay	NNS
cord-006229-7yoilsho	2471	6	revealed	reveal	VBD
cord-006229-7yoilsho	2471	7	that	that	IN
cord-006229-7yoilsho	2471	8	soraphen	soraphen	NN
cord-006229-7yoilsho	2471	9	A	a	DT
cord-006229-7yoilsho	2471	10	can	can	MD
cord-006229-7yoilsho	2471	11	also	also	RB
cord-006229-7yoilsho	2471	12	lower	lower	VB
cord-006229-7yoilsho	2471	13	chemotactic	chemotactic	JJ
cord-006229-7yoilsho	2471	14	migration	migration	NN
cord-006229-7yoilsho	2471	15	by	by	IN
cord-006229-7yoilsho	2471	16	34	34	CD
cord-006229-7yoilsho	2471	17	%	%	NN
cord-006229-7yoilsho	2471	18	.	.	.
cord-006229-7yoilsho	2472	1	Since	since	IN
cord-006229-7yoilsho	2472	2	actin	actin	NN
cord-006229-7yoilsho	2472	3	rearrangement	rearrangement	NN
cord-006229-7yoilsho	2472	4	is	be	VBZ
cord-006229-7yoilsho	2472	5	necessary	necessary	JJ
cord-006229-7yoilsho	2472	6	for	for	IN
cord-006229-7yoilsho	2472	7	migratory	migratory	JJ
cord-006229-7yoilsho	2472	8	processes	process	NNS
cord-006229-7yoilsho	2472	9	,	,	,
cord-006229-7yoilsho	2472	10	we	-PRON-	PRP
cord-006229-7yoilsho	2472	11	analyzed	analyze	VBD
cord-006229-7yoilsho	2472	12	the	the	DT
cord-006229-7yoilsho	2472	13	Factin	Factin	NNP
cord-006229-7yoilsho	2472	14	cytoskeleton	cytoskeleton	NN
cord-006229-7yoilsho	2472	15	(	(	-LRB-
cord-006229-7yoilsho	2472	16	microscopy	microscopy	NNS
cord-006229-7yoilsho	2472	17	)	)	-RRB-
cord-006229-7yoilsho	2472	18	and	and	CC
cord-006229-7yoilsho	2472	19	found	find	VBD
cord-006229-7yoilsho	2472	20	that	that	IN
cord-006229-7yoilsho	2472	21	soraphen	soraphen	NN
cord-006229-7yoilsho	2472	22	A	a	DT
cord-006229-7yoilsho	2472	23	decreases	decrease	VBZ
cord-006229-7yoilsho	2472	24	the	the	DT
cord-006229-7yoilsho	2472	25	number	number	NN
cord-006229-7yoilsho	2472	26	of	of	IN
cord-006229-7yoilsho	2472	27	filopodia	filopodia	NNS
cord-006229-7yoilsho	2472	28	by	by	IN
cord-006229-7yoilsho	2472	29	60	60	CD
cord-006229-7yoilsho	2472	30	%	%	NN
cord-006229-7yoilsho	2472	31	but	but	CC
cord-006229-7yoilsho	2472	32	did	do	VBD
cord-006229-7yoilsho	2472	33	not	not	RB
cord-006229-7yoilsho	2472	34	influence	influence	VB
cord-006229-7yoilsho	2472	35	stress	stress	NN
cord-006229-7yoilsho	2472	36	fiber	fiber	NN
cord-006229-7yoilsho	2472	37	formation	formation	NN
cord-006229-7yoilsho	2472	38	.	.	.
cord-006229-7yoilsho	2473	1	Surprisingly	surprisingly	RB
cord-006229-7yoilsho	2473	2	,	,	,
cord-006229-7yoilsho	2473	3	soraphen	soraphen	NNP
cord-006229-7yoilsho	2473	4	Atreated	Atreated	NNP
cord-006229-7yoilsho	2473	5	cells	cell	NNS
cord-006229-7yoilsho	2473	6	did	do	VBD
cord-006229-7yoilsho	2473	7	not	not	RB
cord-006229-7yoilsho	2473	8	exhibit	exhibit	VB
cord-006229-7yoilsho	2473	9	significant	significant	JJ
cord-006229-7yoilsho	2473	10	alterations	alteration	NNS
cord-006229-7yoilsho	2473	11	in	in	IN
cord-006229-7yoilsho	2473	12	their	-PRON-	PRP$
cord-006229-7yoilsho	2473	13	capacity	capacity	NN
cord-006229-7yoilsho	2473	14	to	to	TO
cord-006229-7yoilsho	2473	15	form	form	VB
cord-006229-7yoilsho	2473	16	tube	tube	NN
cord-006229-7yoilsho	2473	17	-	-	HYPH
cord-006229-7yoilsho	2473	18	like	like	JJ
cord-006229-7yoilsho	2473	19	structures	structure	NNS
cord-006229-7yoilsho	2473	20	on	on	IN
cord-006229-7yoilsho	2473	21	Matrigel	Matrigel	NNP
cord-006229-7yoilsho	2473	22	.	.	.
cord-006229-7yoilsho	2474	1	In	in	IN
cord-006229-7yoilsho	2474	2	summary	summary	NN
cord-006229-7yoilsho	2474	3	,	,	,
cord-006229-7yoilsho	2474	4	we	-PRON-	PRP
cord-006229-7yoilsho	2474	5	could	could	MD
cord-006229-7yoilsho	2474	6	gather	gather	VB
cord-006229-7yoilsho	2474	7	first	first	JJ
cord-006229-7yoilsho	2474	8	hints	hint	NNS
cord-006229-7yoilsho	2474	9	that	that	IN
cord-006229-7yoilsho	2474	10	inhibiting	inhibit	VBG
cord-006229-7yoilsho	2474	11	ACC	ACC	NNP
cord-006229-7yoilsho	2474	12	has	have	VBZ
cord-006229-7yoilsho	2474	13	an	an	DT
cord-006229-7yoilsho	2474	14	immense	immense	JJ
cord-006229-7yoilsho	2474	15	impact	impact	NN
cord-006229-7yoilsho	2474	16	on	on	IN
cord-006229-7yoilsho	2474	17	the	the	DT
cord-006229-7yoilsho	2474	18	proliferation	proliferation	NN
cord-006229-7yoilsho	2474	19	and	and	CC
cord-006229-7yoilsho	2474	20	migration	migration	NN
cord-006229-7yoilsho	2474	21	of	of	IN
cord-006229-7yoilsho	2474	22	primary	primary	JJ
cord-006229-7yoilsho	2474	23	endothelial	endothelial	JJ
cord-006229-7yoilsho	2474	24	cells	cell	NNS
cord-006229-7yoilsho	2474	25	.	.	.
cord-006229-7yoilsho	2475	1	The	the	DT
cord-006229-7yoilsho	2475	2	mechanistic	mechanistic	JJ
cord-006229-7yoilsho	2475	3	basis	basis	NN
cord-006229-7yoilsho	2475	4	of	of	IN
cord-006229-7yoilsho	2475	5	this	this	DT
cord-006229-7yoilsho	2475	6	phenomenon	phenomenon	NN
cord-006229-7yoilsho	2475	7	will	will	MD
cord-006229-7yoilsho	2475	8	be	be	VB
cord-006229-7yoilsho	2475	9	investigated	investigate	VBN
cord-006229-7yoilsho	2475	10	in	in	IN
cord-006229-7yoilsho	2475	11	future	future	JJ
cord-006229-7yoilsho	2475	12	studies	study	NNS
cord-006229-7yoilsho	2475	13	by	by	IN
cord-006229-7yoilsho	2475	14	analyzing	analyze	VBG
cord-006229-7yoilsho	2475	15	the	the	DT
cord-006229-7yoilsho	2475	16	lipid	lipid	NN
cord-006229-7yoilsho	2475	17	profile	profile	NN
cord-006229-7yoilsho	2475	18	and	and	CC
cord-006229-7yoilsho	2475	19	the	the	DT
cord-006229-7yoilsho	2475	20	transcriptome	transcriptome	NN
cord-006229-7yoilsho	2475	21	of	of	IN
cord-006229-7yoilsho	2475	22	endothelial	endothelial	JJ
cord-006229-7yoilsho	2475	23	cells	cell	NNS
cord-006229-7yoilsho	2475	24	.	.	.
cord-006229-7yoilsho	2476	1	Acknowledgement	acknowledgement	NN
cord-006229-7yoilsho	2476	2	:	:	:
cord-006229-7yoilsho	2477	1	This	this	DT
cord-006229-7yoilsho	2477	2	work	work	NN
cord-006229-7yoilsho	2477	3	was	be	VBD
cord-006229-7yoilsho	2477	4	supported	support	VBN
cord-006229-7yoilsho	2477	5	by	by	IN
cord-006229-7yoilsho	2477	6	the	the	DT
cord-006229-7yoilsho	2477	7	German	German	NNP
cord-006229-7yoilsho	2477	8	Research	Research	NNP
cord-006229-7yoilsho	2477	9	Foundation	Foundation	NNP
cord-006229-7yoilsho	2477	10	(	(	-LRB-
cord-006229-7yoilsho	2477	11	DFG	DFG	NNP
cord-006229-7yoilsho	2477	12	,	,	,
cord-006229-7yoilsho	2477	13	FOR	for	IN
cord-006229-7yoilsho	2477	14	1406	1406	CD
cord-006229-7yoilsho	2477	15	,	,	,
cord-006229-7yoilsho	2477	16	FU	FU	NNP
cord-006229-7yoilsho	2477	17	691/9	691/9	CD
cord-006229-7yoilsho	2477	18	-	-	SYM
cord-006229-7yoilsho	2477	19	2	2	CD
cord-006229-7yoilsho	2477	20	)	)	-RRB-
cord-006229-7yoilsho	2477	21	.	.	.
cord-006229-7yoilsho	2478	1	Introduction	introduction	NN
cord-006229-7yoilsho	2478	2	:	:	:
cord-006229-7yoilsho	2479	1	Statins	statin	NNS
cord-006229-7yoilsho	2479	2	are	be	VBP
cord-006229-7yoilsho	2479	3	among	among	IN
cord-006229-7yoilsho	2479	4	the	the	DT
cord-006229-7yoilsho	2479	5	best	good	JJS
cord-006229-7yoilsho	2479	6	examined	examine	VBN
cord-006229-7yoilsho	2479	7	drugs	drug	NNS
cord-006229-7yoilsho	2479	8	with	with	IN
cord-006229-7yoilsho	2479	9	excellent	excellent	JJ
cord-006229-7yoilsho	2479	10	efficacy	efficacy	NN
cord-006229-7yoilsho	2479	11	and	and	CC
cord-006229-7yoilsho	2479	12	safety	safety	NN
cord-006229-7yoilsho	2479	13	profiles	profile	NNS
cord-006229-7yoilsho	2479	14	.	.	.
cord-006229-7yoilsho	2480	1	Lowered	lower	VBN
cord-006229-7yoilsho	2480	2	low	low	JJ
cord-006229-7yoilsho	2480	3	-	-	HYPH
cord-006229-7yoilsho	2480	4	density	density	NN
cord-006229-7yoilsho	2480	5	lipoprotein	lipoprotein	NN
cord-006229-7yoilsho	2480	6	(	(	-LRB-
cord-006229-7yoilsho	2480	7	LDL	LDL	NNP
cord-006229-7yoilsho	2480	8	)	)	-RRB-
cord-006229-7yoilsho	2480	9	cholesterol	cholesterol	NN
cord-006229-7yoilsho	2480	10	goals	goal	NNS
cord-006229-7yoilsho	2480	11	,	,	,
cord-006229-7yoilsho	2480	12	new	new	JJ
cord-006229-7yoilsho	2480	13	indications	indication	NNS
cord-006229-7yoilsho	2480	14	for	for	IN
cord-006229-7yoilsho	2480	15	treatment	treatment	NN
cord-006229-7yoilsho	2480	16	and	and	CC
cord-006229-7yoilsho	2480	17	new	new	JJ
cord-006229-7yoilsho	2480	18	knowledge	knowledge	NN
cord-006229-7yoilsho	2480	19	about	about	IN
cord-006229-7yoilsho	2480	20	their	-PRON-	PRP$
cord-006229-7yoilsho	2480	21	pleiotropic	pleiotropic	JJ
cord-006229-7yoilsho	2480	22	effect	effect	NN
cord-006229-7yoilsho	2480	23	have	have	VBP
cord-006229-7yoilsho	2480	24	promoted	promote	VBN
cord-006229-7yoilsho	2480	25	a	a	DT
cord-006229-7yoilsho	2480	26	considerable	considerable	JJ
cord-006229-7yoilsho	2480	27	increase	increase	NN
cord-006229-7yoilsho	2480	28	in	in	IN
cord-006229-7yoilsho	2480	29	statin	statin	NN
cord-006229-7yoilsho	2480	30	use	use	NN
cord-006229-7yoilsho	2480	31	.	.	.
cord-006229-7yoilsho	2481	1	But	but	CC
cord-006229-7yoilsho	2481	2	as	as	IN
cord-006229-7yoilsho	2481	3	statin	statin	NN
cord-006229-7yoilsho	2481	4	use	use	NN
cord-006229-7yoilsho	2481	5	becomes	become	VBZ
cord-006229-7yoilsho	2481	6	more	more	RBR
cord-006229-7yoilsho	2481	7	widespread	widespread	JJ
cord-006229-7yoilsho	2481	8	,	,	,
cord-006229-7yoilsho	2481	9	awareness	awareness	NN
cord-006229-7yoilsho	2481	10	of	of	IN
cord-006229-7yoilsho	2481	11	their	-PRON-	PRP$
cord-006229-7yoilsho	2481	12	adverse	adverse	JJ
cord-006229-7yoilsho	2481	13	effects	effect	NNS
cord-006229-7yoilsho	2481	14	as	as	RB
cord-006229-7yoilsho	2481	15	well	well	RB
cord-006229-7yoilsho	2481	16	as	as	IN
cord-006229-7yoilsho	2481	17	the	the	DT
cord-006229-7yoilsho	2481	18	recognition	recognition	NN
cord-006229-7yoilsho	2481	19	of	of	IN
cord-006229-7yoilsho	2481	20	statin	statin	NN
cord-006229-7yoilsho	2481	21	intolerance	intolerance	NN
cord-006229-7yoilsho	2481	22	problems	problem	NNS
cord-006229-7yoilsho	2481	23	increase	increase	VBP
cord-006229-7yoilsho	2481	24	.	.	.
cord-006229-7yoilsho	2482	1	Statin	statin	NN
cord-006229-7yoilsho	2482	2	intolerance	intolerance	NN
cord-006229-7yoilsho	2482	3	is	be	VBZ
cord-006229-7yoilsho	2482	4	a	a	DT
cord-006229-7yoilsho	2482	5	significant	significant	JJ
cord-006229-7yoilsho	2482	6	problem	problem	NN
cord-006229-7yoilsho	2482	7	in	in	IN
cord-006229-7yoilsho	2482	8	the	the	DT
cord-006229-7yoilsho	2482	9	treatment	treatment	NN
cord-006229-7yoilsho	2482	10	of	of	IN
cord-006229-7yoilsho	2482	11	dyslipidemia	dyslipidemia	NN
cord-006229-7yoilsho	2482	12	,	,	,
cord-006229-7yoilsho	2482	13	understood	understand	VBD
cord-006229-7yoilsho	2482	14	as	as	IN
cord-006229-7yoilsho	2482	15	the	the	DT
cord-006229-7yoilsho	2482	16	inability	inability	NN
cord-006229-7yoilsho	2482	17	to	to	TO
cord-006229-7yoilsho	2482	18	tolerate	tolerate	VB
cord-006229-7yoilsho	2482	19	a	a	DT
cord-006229-7yoilsho	2482	20	dose	dose	NN
cord-006229-7yoilsho	2482	21	of	of	IN
cord-006229-7yoilsho	2482	22	statin	statin	NN
cord-006229-7yoilsho	2482	23	required	require	VBN
cord-006229-7yoilsho	2482	24	to	to	TO
cord-006229-7yoilsho	2482	25	reduce	reduce	VB
cord-006229-7yoilsho	2482	26	individual	individual	JJ
cord-006229-7yoilsho	2482	27	cardiovascular	cardiovascular	JJ
cord-006229-7yoilsho	2482	28	risk	risk	NN
cord-006229-7yoilsho	2482	29	sufficiently	sufficiently	RB
cord-006229-7yoilsho	2482	30	and	and	CC
cord-006229-7yoilsho	2482	31	could	could	MD
cord-006229-7yoilsho	2482	32	result	result	VB
cord-006229-7yoilsho	2482	33	from	from	IN
cord-006229-7yoilsho	2482	34	different	different	JJ
cord-006229-7yoilsho	2482	35	statin	statin	NN
cord-006229-7yoilsho	2482	36	-	-	HYPH
cord-006229-7yoilsho	2482	37	related	relate	VBN
cord-006229-7yoilsho	2482	38	side	side	NN
cord-006229-7yoilsho	2482	39	effects	effect	NNS
cord-006229-7yoilsho	2482	40	.	.	.
cord-006229-7yoilsho	2483	1	Muscle	muscle	NN
cord-006229-7yoilsho	2483	2	-	-	HYPH
cord-006229-7yoilsho	2483	3	related	relate	VBN
cord-006229-7yoilsho	2483	4	adverse	adverse	JJ
cord-006229-7yoilsho	2483	5	events	event	NNS
cord-006229-7yoilsho	2483	6	,	,	,
cord-006229-7yoilsho	2483	7	elevation	elevation	NN
cord-006229-7yoilsho	2483	8	of	of	IN
cord-006229-7yoilsho	2483	9	liver	liver	NN
cord-006229-7yoilsho	2483	10	enzymes	enzyme	NNS
cord-006229-7yoilsho	2483	11	,	,	,
cord-006229-7yoilsho	2483	12	cognitive	cognitive	JJ
cord-006229-7yoilsho	2483	13	problems	problem	NNS
cord-006229-7yoilsho	2483	14	and	and	CC
cord-006229-7yoilsho	2483	15	new	new	JJ
cord-006229-7yoilsho	2483	16	onset	onset	NN
cord-006229-7yoilsho	2483	17	diabetes	diabetes	NN
cord-006229-7yoilsho	2483	18	mellitus	mellitus	NN
cord-006229-7yoilsho	2483	19	have	have	VBP
cord-006229-7yoilsho	2483	20	all	all	DT
cord-006229-7yoilsho	2483	21	been	be	VBN
cord-006229-7yoilsho	2483	22	described	describe	VBN
cord-006229-7yoilsho	2483	23	,	,	,
cord-006229-7yoilsho	2483	24	especially	especially	RB
cord-006229-7yoilsho	2483	25	at	at	IN
cord-006229-7yoilsho	2483	26	higher	high	JJR
cord-006229-7yoilsho	2483	27	doses	dose	NNS
cord-006229-7yoilsho	2483	28	.	.	.
cord-006229-7yoilsho	2484	1	Although	although	IN
cord-006229-7yoilsho	2484	2	muscle	muscle	NN
cord-006229-7yoilsho	2484	3	symptoms	symptom	NNS
cord-006229-7yoilsho	2484	4	are	be	VBP
cord-006229-7yoilsho	2484	5	the	the	DT
cord-006229-7yoilsho	2484	6	common	common	JJ
cord-006229-7yoilsho	2484	7	side	side	NN
cord-006229-7yoilsho	2484	8	effects	effect	NNS
cord-006229-7yoilsho	2484	9	observed	observe	VBN
cord-006229-7yoilsho	2484	10	,	,	,
cord-006229-7yoilsho	2484	11	excluding	exclude	VBG
cord-006229-7yoilsho	2484	12	other	other	JJ
cord-006229-7yoilsho	2484	13	adverse	adverse	JJ
cord-006229-7yoilsho	2484	14	events	event	NNS
cord-006229-7yoilsho	2484	15	might	may	MD
cord-006229-7yoilsho	2484	16	underestimate	underestimate	VB
cord-006229-7yoilsho	2484	17	the	the	DT
cord-006229-7yoilsho	2484	18	number	number	NN
cord-006229-7yoilsho	2484	19	of	of	IN
cord-006229-7yoilsho	2484	20	patients	patient	NNS
cord-006229-7yoilsho	2484	21	with	with	IN
cord-006229-7yoilsho	2484	22	true	true	JJ
cord-006229-7yoilsho	2484	23	statin	statin	NN
cord-006229-7yoilsho	2484	24	intolerance	intolerance	NN
cord-006229-7yoilsho	2484	25	.	.	.
cord-006229-7yoilsho	2485	1	These	these	DT
cord-006229-7yoilsho	2485	2	patients	patient	NNS
cord-006229-7yoilsho	2485	3	represent	represent	VBP
cord-006229-7yoilsho	2485	4	a	a	DT
cord-006229-7yoilsho	2485	5	target	target	NN
cord-006229-7yoilsho	2485	6	population	population	NN
cord-006229-7yoilsho	2485	7	for	for	IN
cord-006229-7yoilsho	2485	8	the	the	DT
cord-006229-7yoilsho	2485	9	newest	new	JJS
cord-006229-7yoilsho	2485	10	lipid	lipid	NN
cord-006229-7yoilsho	2485	11	lowering	lower	VBG
cord-006229-7yoilsho	2485	12	drug	drug	NN
cord-006229-7yoilsho	2485	13	category	category	NN
cord-006229-7yoilsho	2485	14	i.e.	i.e.	FW
cord-006229-7yoilsho	2485	15	the	the	DT
cord-006229-7yoilsho	2485	16	proprotein	proprotein	NNP
cord-006229-7yoilsho	2485	17	convertase	convertase	NNP
cord-006229-7yoilsho	2485	18	subtilisin	subtilisin	NNP
cord-006229-7yoilsho	2485	19	/	/	SYM
cord-006229-7yoilsho	2485	20	kexin	kexin	NNP
cord-006229-7yoilsho	2485	21	type	type	NNP
cord-006229-7yoilsho	2485	22	9	9	CD
cord-006229-7yoilsho	2485	23	(	(	-LRB-
cord-006229-7yoilsho	2485	24	PCSK9	pcsk9	NN
cord-006229-7yoilsho	2485	25	)	)	-RRB-
cord-006229-7yoilsho	2485	26	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	2485	27	.	.	.
cord-006229-7yoilsho	2486	1	This	this	DT
cord-006229-7yoilsho	2486	2	work	work	NN
cord-006229-7yoilsho	2486	3	aimed	aim	VBN
cord-006229-7yoilsho	2486	4	to	to	TO
cord-006229-7yoilsho	2486	5	give	give	VB
cord-006229-7yoilsho	2486	6	an	an	DT
cord-006229-7yoilsho	2486	7	overview	overview	NN
cord-006229-7yoilsho	2486	8	of	of	IN
cord-006229-7yoilsho	2486	9	published	publish	VBN
cord-006229-7yoilsho	2486	10	definitions	definition	NNS
cord-006229-7yoilsho	2486	11	derived	derive	VBN
cord-006229-7yoilsho	2486	12	from	from	IN
cord-006229-7yoilsho	2486	13	clinical	clinical	JJ
cord-006229-7yoilsho	2486	14	studies	study	NNS
cord-006229-7yoilsho	2486	15	,	,	,
cord-006229-7yoilsho	2486	16	associations	association	NNS
cord-006229-7yoilsho	2486	17	as	as	RB
cord-006229-7yoilsho	2486	18	well	well	RB
cord-006229-7yoilsho	2486	19	as	as	IN
cord-006229-7yoilsho	2486	20	major	major	JJ
cord-006229-7yoilsho	2486	21	drug	drug	NN
cord-006229-7yoilsho	2486	22	regulatory	regulatory	JJ
cord-006229-7yoilsho	2486	23	agencies	agency	NNS
cord-006229-7yoilsho	2486	24	.	.	.
cord-006229-7yoilsho	2487	1	We	-PRON-	PRP
cord-006229-7yoilsho	2487	2	discussed	discuss	VBD
cord-006229-7yoilsho	2487	3	overlaps	overlap	NNS
cord-006229-7yoilsho	2487	4	,	,	,
cord-006229-7yoilsho	2487	5	differences	difference	NNS
cord-006229-7yoilsho	2487	6	and	and	CC
cord-006229-7yoilsho	2487	7	limitations	limitation	NNS
cord-006229-7yoilsho	2487	8	in	in	IN
cord-006229-7yoilsho	2487	9	the	the	DT
cord-006229-7yoilsho	2487	10	current	current	JJ
cord-006229-7yoilsho	2487	11	definitions	definition	NNS
cord-006229-7yoilsho	2487	12	.	.	.
cord-006229-7yoilsho	2488	1	Methods	method	NNS
cord-006229-7yoilsho	2488	2	:	:	:
cord-006229-7yoilsho	2489	1	Literature	literature	NN
cord-006229-7yoilsho	2489	2	based	base	VBN
cord-006229-7yoilsho	2489	3	search	search	NN
cord-006229-7yoilsho	2489	4	included	include	VBD
cord-006229-7yoilsho	2489	5	PubMed	PubMed	NNP
cord-006229-7yoilsho	2489	6	and	and	CC
cord-006229-7yoilsho	2489	7	UpToDate	uptodate	JJ
cord-006229-7yoilsho	2489	8	publications	publication	NNS
cord-006229-7yoilsho	2489	9	in	in	IN
cord-006229-7yoilsho	2489	10	English	English	NNP
cord-006229-7yoilsho	2489	11	and	and	CC
cord-006229-7yoilsho	2489	12	German	german	JJ
cord-006229-7yoilsho	2489	13	language	language	NN
cord-006229-7yoilsho	2489	14	until	until	IN
cord-006229-7yoilsho	2489	15	October	October	NNP
cord-006229-7yoilsho	2489	16	2015	2015	CD
cord-006229-7yoilsho	2489	17	.	.	.
cord-006229-7yoilsho	2490	1	We	-PRON-	PRP
cord-006229-7yoilsho	2490	2	performed	perform	VBD
cord-006229-7yoilsho	2490	3	hand	hand	NN
cord-006229-7yoilsho	2490	4	searches	search	NNS
cord-006229-7yoilsho	2490	5	of	of	IN
cord-006229-7yoilsho	2490	6	the	the	DT
cord-006229-7yoilsho	2490	7	references	reference	NNS
cord-006229-7yoilsho	2490	8	retrieved	retrieve	VBN
cord-006229-7yoilsho	2490	9	and	and	CC
cord-006229-7yoilsho	2490	10	performed	perform	VBD
cord-006229-7yoilsho	2490	11	an	an	DT
cord-006229-7yoilsho	2490	12	overview	overview	NN
cord-006229-7yoilsho	2490	13	.	.	.
cord-006229-7yoilsho	2491	1	Results	result	NNS
cord-006229-7yoilsho	2491	2	:	:	:
cord-006229-7yoilsho	2492	1	A	a	DT
cord-006229-7yoilsho	2492	2	definition	definition	NN
cord-006229-7yoilsho	2492	3	of	of	IN
cord-006229-7yoilsho	2492	4	statin	statin	NN
cord-006229-7yoilsho	2492	5	intolerance	intolerance	NN
cord-006229-7yoilsho	2492	6	of	of	IN
cord-006229-7yoilsho	2492	7	the	the	DT
cord-006229-7yoilsho	2492	8	European	European	NNP
cord-006229-7yoilsho	2492	9	Medicines	Medicines	NNPS
cord-006229-7yoilsho	2492	10	Agency	Agency	NNP
cord-006229-7yoilsho	2492	11	(	(	-LRB-
cord-006229-7yoilsho	2492	12	EMA	EMA	NNP
cord-006229-7yoilsho	2492	13	)	)	-RRB-
cord-006229-7yoilsho	2492	14	or	or	CC
cord-006229-7yoilsho	2492	15	the	the	DT
cord-006229-7yoilsho	2492	16	US	US	NNP
cord-006229-7yoilsho	2492	17	Food	Food	NNP
cord-006229-7yoilsho	2492	18	and	and	CC
cord-006229-7yoilsho	2492	19	Drug	Drug	NNP
cord-006229-7yoilsho	2492	20	Administration	Administration	NNP
cord-006229-7yoilsho	2492	21	(	(	-LRB-
cord-006229-7yoilsho	2492	22	FDA	FDA	NNP
cord-006229-7yoilsho	2492	23	)	)	-RRB-
cord-006229-7yoilsho	2492	24	is	be	VBZ
cord-006229-7yoilsho	2492	25	not	not	RB
cord-006229-7yoilsho	2492	26	available	available	JJ
cord-006229-7yoilsho	2492	27	.	.	.
cord-006229-7yoilsho	2493	1	In	in	IN
cord-006229-7yoilsho	2493	2	clinical	clinical	JJ
cord-006229-7yoilsho	2493	3	studies	study	NNS
cord-006229-7yoilsho	2493	4	,	,	,
cord-006229-7yoilsho	2493	5	different	different	JJ
cord-006229-7yoilsho	2493	6	definitions	definition	NNS
cord-006229-7yoilsho	2493	7	are	be	VBP
cord-006229-7yoilsho	2493	8	chosen	choose	VBN
cord-006229-7yoilsho	2493	9	and	and	CC
cord-006229-7yoilsho	2493	10	the	the	DT
cord-006229-7yoilsho	2493	11	results	result	NNS
cord-006229-7yoilsho	2493	12	are	be	VBP
cord-006229-7yoilsho	2493	13	not	not	RB
cord-006229-7yoilsho	2493	14	comparable	comparable	JJ
cord-006229-7yoilsho	2493	15	.	.	.
cord-006229-7yoilsho	2494	1	Also	also	RB
cord-006229-7yoilsho	2494	2	different	different	JJ
cord-006229-7yoilsho	2494	3	associations	association	NNS
cord-006229-7yoilsho	2494	4	,	,	,
cord-006229-7yoilsho	2494	5	such	such	JJ
cord-006229-7yoilsho	2494	6	as	as	IN
cord-006229-7yoilsho	2494	7	the	the	DT
cord-006229-7yoilsho	2494	8	American	American	NNP
cord-006229-7yoilsho	2494	9	Heart	Heart	NNP
cord-006229-7yoilsho	2494	10	Association	Association	NNP
cord-006229-7yoilsho	2494	11	(	(	-LRB-
cord-006229-7yoilsho	2494	12	AHA	AHA	NNP
cord-006229-7yoilsho	2494	13	)	)	-RRB-
cord-006229-7yoilsho	2494	14	,	,	,
cord-006229-7yoilsho	2494	15	the	the	DT
cord-006229-7yoilsho	2494	16	European	European	NNP
cord-006229-7yoilsho	2494	17	Atherosclerosis	Atherosclerosis	NNP
cord-006229-7yoilsho	2494	18	Society	Society	NNP
cord-006229-7yoilsho	2494	19	(	(	-LRB-
cord-006229-7yoilsho	2494	20	EAS	EAS	NNP
cord-006229-7yoilsho	2494	21	)	)	-RRB-
cord-006229-7yoilsho	2494	22	,	,	,
cord-006229-7yoilsho	2494	23	the	the	DT
cord-006229-7yoilsho	2494	24	Canadian	Canadian	NNP
cord-006229-7yoilsho	2494	25	Working	Working	NNP
cord-006229-7yoilsho	2494	26	Group	Group	NNP
cord-006229-7yoilsho	2494	27	or	or	CC
cord-006229-7yoilsho	2494	28	the	the	DT
cord-006229-7yoilsho	2494	29	National	National	NNP
cord-006229-7yoilsho	2494	30	Lipid	Lipid	NNP
cord-006229-7yoilsho	2494	31	Association	Association	NNP
cord-006229-7yoilsho	2494	32	(	(	-LRB-
cord-006229-7yoilsho	2494	33	NLA	NLA	NNP
cord-006229-7yoilsho	2494	34	)	)	-RRB-
cord-006229-7yoilsho	2494	35	are	be	VBP
cord-006229-7yoilsho	2494	36	not	not	RB
cord-006229-7yoilsho	2494	37	able	able	JJ
cord-006229-7yoilsho	2494	38	to	to	TO
cord-006229-7yoilsho	2494	39	agree	agree	VB
cord-006229-7yoilsho	2494	40	on	on	IN
cord-006229-7yoilsho	2494	41	one	one	CD
cord-006229-7yoilsho	2494	42	common	common	JJ
cord-006229-7yoilsho	2494	43	definition	definition	NN
cord-006229-7yoilsho	2494	44	.	.	.
cord-006229-7yoilsho	2495	1	Statin	statin	NN
cord-006229-7yoilsho	2495	2	intolerance	intolerance	NN
cord-006229-7yoilsho	2495	3	definitions	definition	NNS
cord-006229-7yoilsho	2495	4	included	include	VBD
cord-006229-7yoilsho	2495	5	different	different	JJ
cord-006229-7yoilsho	2495	6	types	type	NNS
cord-006229-7yoilsho	2495	7	of	of	IN
cord-006229-7yoilsho	2495	8	muscle	muscle	NN
cord-006229-7yoilsho	2495	9	symptoms	symptom	NNS
cord-006229-7yoilsho	2495	10	,	,	,
cord-006229-7yoilsho	2495	11	integration	integration	NN
cord-006229-7yoilsho	2495	12	of	of	IN
cord-006229-7yoilsho	2495	13	CK	CK	NNP
cord-006229-7yoilsho	2495	14	levels	level	NNS
cord-006229-7yoilsho	2495	15	and	and	CC
cord-006229-7yoilsho	2495	16	minimal	minimal	JJ
cord-006229-7yoilsho	2495	17	requirements	requirement	NNS
cord-006229-7yoilsho	2495	18	of	of	IN
cord-006229-7yoilsho	2495	19	statin	statin	NN
cord-006229-7yoilsho	2495	20	doses	dose	NNS
cord-006229-7yoilsho	2495	21	.	.	.
cord-006229-7yoilsho	2496	1	There	there	EX
cord-006229-7yoilsho	2496	2	are	be	VBP
cord-006229-7yoilsho	2496	3	currently	currently	RB
cord-006229-7yoilsho	2496	4	no	no	DT
cord-006229-7yoilsho	2496	5	validated	validate	VBN
cord-006229-7yoilsho	2496	6	questionnaires	questionnaire	NNS
cord-006229-7yoilsho	2496	7	or	or	CC
cord-006229-7yoilsho	2496	8	specific	specific	JJ
cord-006229-7yoilsho	2496	9	laboratory	laboratory	NN
cord-006229-7yoilsho	2496	10	parameters	parameter	NNS
cord-006229-7yoilsho	2496	11	available	available	JJ
cord-006229-7yoilsho	2496	12	.	.	.
cord-006229-7yoilsho	2497	1	In	in	IN
cord-006229-7yoilsho	2497	2	addition	addition	NN
cord-006229-7yoilsho	2497	3	,	,	,
cord-006229-7yoilsho	2497	4	the	the	DT
cord-006229-7yoilsho	2497	5	term	term	NN
cord-006229-7yoilsho	2497	6	'	'	``
cord-006229-7yoilsho	2497	7	myopathy	myopathy	NN
cord-006229-7yoilsho	2497	8	'	'	''
cord-006229-7yoilsho	2497	9	is	be	VBZ
cord-006229-7yoilsho	2497	10	often	often	RB
cord-006229-7yoilsho	2497	11	considered	consider	VBN
cord-006229-7yoilsho	2497	12	as	as	IN
cord-006229-7yoilsho	2497	13	a	a	DT
cord-006229-7yoilsho	2497	14	synonym	synonym	NN
cord-006229-7yoilsho	2497	15	to	to	TO
cord-006229-7yoilsho	2497	16	statin	statin	VB
cord-006229-7yoilsho	2497	17	intolerance	intolerance	NN
cord-006229-7yoilsho	2497	18	.	.	.
cord-006229-7yoilsho	2498	1	Overall	overall	RB
cord-006229-7yoilsho	2498	2	,	,	,
cord-006229-7yoilsho	2498	3	only	only	RB
cord-006229-7yoilsho	2498	4	a	a	DT
cord-006229-7yoilsho	2498	5	few	few	JJ
cord-006229-7yoilsho	2498	6	major	major	JJ
cord-006229-7yoilsho	2498	7	studies	study	NNS
cord-006229-7yoilsho	2498	8	have	have	VBP
cord-006229-7yoilsho	2498	9	been	be	VBN
cord-006229-7yoilsho	2498	10	conducted	conduct	VBN
cord-006229-7yoilsho	2498	11	with	with	IN
cord-006229-7yoilsho	2498	12	statin	statin	NN
cord-006229-7yoilsho	2498	13	intolerant	intolerant	JJ
cord-006229-7yoilsho	2498	14	patients	patient	NNS
cord-006229-7yoilsho	2498	15	so	so	RB
cord-006229-7yoilsho	2498	16	far	far	RB
cord-006229-7yoilsho	2498	17	using	use	VBG
cord-006229-7yoilsho	2498	18	inconsistent	inconsistent	JJ
cord-006229-7yoilsho	2498	19	definitions	definition	NNS
cord-006229-7yoilsho	2498	20	.	.	.
cord-006229-7yoilsho	2499	1	Discussion	discussion	NN
cord-006229-7yoilsho	2499	2	and	and	CC
cord-006229-7yoilsho	2499	3	Conclusion	conclusion	NN
cord-006229-7yoilsho	2500	1	:	:	:
cord-006229-7yoilsho	2500	2	There	there	EX
cord-006229-7yoilsho	2500	3	is	be	VBZ
cord-006229-7yoilsho	2500	4	an	an	DT
cord-006229-7yoilsho	2500	5	unmet	unmet	JJ
cord-006229-7yoilsho	2500	6	need	need	NN
cord-006229-7yoilsho	2500	7	to	to	TO
cord-006229-7yoilsho	2500	8	find	find	VB
cord-006229-7yoilsho	2500	9	a	a	DT
cord-006229-7yoilsho	2500	10	robust	robust	JJ
cord-006229-7yoilsho	2500	11	and	and	CC
cord-006229-7yoilsho	2500	12	clear	clear	JJ
cord-006229-7yoilsho	2500	13	definition	definition	NN
cord-006229-7yoilsho	2500	14	of	of	IN
cord-006229-7yoilsho	2500	15	statin	statin	NN
cord-006229-7yoilsho	2500	16	intolerance	intolerance	NN
cord-006229-7yoilsho	2500	17	as	as	IN
cord-006229-7yoilsho	2500	18	overemphasizing	overemphasize	VBG
cord-006229-7yoilsho	2500	19	it	-PRON-	PRP
cord-006229-7yoilsho	2500	20	might	may	MD
cord-006229-7yoilsho	2500	21	hinder	hinder	VB
cord-006229-7yoilsho	2500	22	appropriate	appropriate	JJ
cord-006229-7yoilsho	2500	23	clinical	clinical	JJ
cord-006229-7yoilsho	2500	24	use	use	NN
cord-006229-7yoilsho	2500	25	of	of	IN
cord-006229-7yoilsho	2500	26	this	this	DT
cord-006229-7yoilsho	2500	27	important	important	JJ
cord-006229-7yoilsho	2500	28	drug	drug	NN
cord-006229-7yoilsho	2500	29	class	class	NN
cord-006229-7yoilsho	2500	30	.	.	.
cord-006229-7yoilsho	2501	1	Thus	thus	RB
cord-006229-7yoilsho	2501	2	,	,	,
cord-006229-7yoilsho	2501	3	further	further	JJ
cord-006229-7yoilsho	2501	4	work	work	NN
cord-006229-7yoilsho	2501	5	is	be	VBZ
cord-006229-7yoilsho	2501	6	required	require	VBN
cord-006229-7yoilsho	2501	7	to	to	TO
cord-006229-7yoilsho	2501	8	develop	develop	VB
cord-006229-7yoilsho	2501	9	a	a	DT
cord-006229-7yoilsho	2501	10	consensus	consensus	NN
cord-006229-7yoilsho	2501	11	definition	definition	NN
cord-006229-7yoilsho	2501	12	on	on	IN
cord-006229-7yoilsho	2501	13	statin	statin	NN
cord-006229-7yoilsho	2501	14	intolerance	intolerance	NN
cord-006229-7yoilsho	2501	15	or	or	CC
cord-006229-7yoilsho	2501	16	a	a	DT
cord-006229-7yoilsho	2501	17	more	more	RBR
cord-006229-7yoilsho	2501	18	focused	focused	JJ
cord-006229-7yoilsho	2501	19	definition	definition	NN
cord-006229-7yoilsho	2501	20	regarding	regard	VBG
cord-006229-7yoilsho	2501	21	statin	statin	NN
cord-006229-7yoilsho	2501	22	-	-	HYPH
cord-006229-7yoilsho	2501	23	associated	associate	VBN
cord-006229-7yoilsho	2501	24	muscle	muscle	NN
cord-006229-7yoilsho	2501	25	symptoms	symptom	NNS
cord-006229-7yoilsho	2501	26	only	only	RB
cord-006229-7yoilsho	2501	27	.	.	.
cord-006229-7yoilsho	2502	1	Subsequently	subsequently	RB
cord-006229-7yoilsho	2502	2	,	,	,
cord-006229-7yoilsho	2502	3	these	these	DT
cord-006229-7yoilsho	2502	4	definitions	definition	NNS
cord-006229-7yoilsho	2502	5	could	could	MD
cord-006229-7yoilsho	2502	6	be	be	VB
cord-006229-7yoilsho	2502	7	implemented	implement	VBN
cord-006229-7yoilsho	2502	8	in	in	IN
cord-006229-7yoilsho	2502	9	patient	patient	JJ
cord-006229-7yoilsho	2502	10	care	care	NN
cord-006229-7yoilsho	2502	11	and	and	CC
cord-006229-7yoilsho	2502	12	their	-PRON-	PRP$
cord-006229-7yoilsho	2502	13	relevance	relevance	NN
cord-006229-7yoilsho	2502	14	being	be	VBG
cord-006229-7yoilsho	2502	15	analyzed	analyze	VBN
cord-006229-7yoilsho	2502	16	and	and	CC
cord-006229-7yoilsho	2502	17	tested	test	VBN
cord-006229-7yoilsho	2502	18	in	in	IN
cord-006229-7yoilsho	2502	19	future	future	JJ
cord-006229-7yoilsho	2502	20	studies	study	NNS
cord-006229-7yoilsho	2502	21	.	.	.
cord-006229-7yoilsho	2503	1	Background	background	NN
cord-006229-7yoilsho	2503	2	:	:	:
cord-006229-7yoilsho	2504	1	Development	development	NN
cord-006229-7yoilsho	2504	2	of	of	IN
cord-006229-7yoilsho	2504	3	cardiac	cardiac	JJ
cord-006229-7yoilsho	2504	4	hypertrophy	hypertrophy	NN
cord-006229-7yoilsho	2504	5	is	be	VBZ
cord-006229-7yoilsho	2504	6	characterized	characterize	VBN
cord-006229-7yoilsho	2504	7	by	by	IN
cord-006229-7yoilsho	2504	8	reactivation	reactivation	NN
cord-006229-7yoilsho	2504	9	of	of	IN
cord-006229-7yoilsho	2504	10	genes	gene	NNS
cord-006229-7yoilsho	2504	11	involved	involve	VBN
cord-006229-7yoilsho	2504	12	in	in	IN
cord-006229-7yoilsho	2504	13	cardiac	cardiac	JJ
cord-006229-7yoilsho	2504	14	development	development	NN
cord-006229-7yoilsho	2504	15	.	.	.
cord-006229-7yoilsho	2505	1	Wnt	Wnt	NNP
cord-006229-7yoilsho	2505	2	/	/	SYM
cord-006229-7yoilsho	2505	3	β	β	NN
cord-006229-7yoilsho	2505	4	-	-	HYPH
cord-006229-7yoilsho	2505	5	catenin	catenin	NNP
cord-006229-7yoilsho	2505	6	signaling	signaling	NN
cord-006229-7yoilsho	2505	7	is	be	VBZ
cord-006229-7yoilsho	2505	8	essential	essential	JJ
cord-006229-7yoilsho	2505	9	for	for	IN
cord-006229-7yoilsho	2505	10	embryonic	embryonic	JJ
cord-006229-7yoilsho	2505	11	cardiac	cardiac	JJ
cord-006229-7yoilsho	2505	12	development	development	NN
cord-006229-7yoilsho	2505	13	and	and	CC
cord-006229-7yoilsho	2505	14	is	be	VBZ
cord-006229-7yoilsho	2505	15	known	know	VBN
cord-006229-7yoilsho	2505	16	to	to	TO
cord-006229-7yoilsho	2505	17	be	be	VB
cord-006229-7yoilsho	2505	18	dysregulated	dysregulate	VBN
cord-006229-7yoilsho	2505	19	in	in	IN
cord-006229-7yoilsho	2505	20	pathological	pathological	JJ
cord-006229-7yoilsho	2505	21	heart	heart	NN
cord-006229-7yoilsho	2505	22	remodeling	remodeling	NN
cord-006229-7yoilsho	2505	23	.	.	.
cord-006229-7yoilsho	2506	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	2506	2	previous	previous	JJ
cord-006229-7yoilsho	2506	3	work	work	NN
cord-006229-7yoilsho	2506	4	suggested	suggest	VBD
cord-006229-7yoilsho	2506	5	a	a	DT
cord-006229-7yoilsho	2506	6	cardiac	cardiac	JJ
cord-006229-7yoilsho	2506	7	specific	specific	JJ
cord-006229-7yoilsho	2506	8	protein	protein	NN
cord-006229-7yoilsho	2506	9	complex	complex	NN
cord-006229-7yoilsho	2506	10	regulating	regulate	VBG
cord-006229-7yoilsho	2506	11	Wnt	Wnt	NNP
cord-006229-7yoilsho	2506	12	/	/	SYM
cord-006229-7yoilsho	2506	13	b	b	NN
cord-006229-7yoilsho	2506	14	-	-	HYPH
cord-006229-7yoilsho	2506	15	catenin	catenin	NNP
cord-006229-7yoilsho	2506	16	/	/	SYM
cord-006229-7yoilsho	2506	17	TCF	tcf	NN
cord-006229-7yoilsho	2506	18	transcription	transcription	NN
cord-006229-7yoilsho	2506	19	in	in	IN
cord-006229-7yoilsho	2506	20	the	the	DT
cord-006229-7yoilsho	2506	21	adult	adult	NN
cord-006229-7yoilsho	2506	22	heart	heart	NN
cord-006229-7yoilsho	2506	23	.	.	.
cord-006229-7yoilsho	2507	1	We	-PRON-	PRP
cord-006229-7yoilsho	2507	2	aim	aim	VBP
cord-006229-7yoilsho	2507	3	to	to	TO
cord-006229-7yoilsho	2507	4	identify	identify	VB
cord-006229-7yoilsho	2507	5	and	and	CC
cord-006229-7yoilsho	2507	6	to	to	TO
cord-006229-7yoilsho	2507	7	characterize	characterize	VB
cord-006229-7yoilsho	2507	8	this	this	DT
cord-006229-7yoilsho	2507	9	complex	complex	NN
cord-006229-7yoilsho	2507	10	in	in	IN
cord-006229-7yoilsho	2507	11	order	order	NN
cord-006229-7yoilsho	2507	12	to	to	TO
cord-006229-7yoilsho	2507	13	find	find	VB
cord-006229-7yoilsho	2507	14	potentially	potentially	RB
cord-006229-7yoilsho	2507	15	interesting	interesting	JJ
cord-006229-7yoilsho	2507	16	targets	target	NNS
cord-006229-7yoilsho	2507	17	for	for	IN
cord-006229-7yoilsho	2507	18	pharmacological	pharmacological	JJ
cord-006229-7yoilsho	2507	19	therapy	therapy	NN
cord-006229-7yoilsho	2507	20	preventing	prevent	VBG
cord-006229-7yoilsho	2507	21	maladaptive	maladaptive	JJ
cord-006229-7yoilsho	2507	22	cardiac	cardiac	JJ
cord-006229-7yoilsho	2507	23	remodeling	remodeling	NN
cord-006229-7yoilsho	2507	24	and	and	CC
cord-006229-7yoilsho	2507	25	the	the	DT
cord-006229-7yoilsho	2507	26	onset	onset	NN
cord-006229-7yoilsho	2507	27	of	of	IN
cord-006229-7yoilsho	2507	28	heart	heart	NN
cord-006229-7yoilsho	2507	29	failure	failure	NN
cord-006229-7yoilsho	2507	30	.	.	.
cord-006229-7yoilsho	2508	1	Results	result	NNS
cord-006229-7yoilsho	2508	2	:	:	:
cord-006229-7yoilsho	2509	1	We	-PRON-	PRP
cord-006229-7yoilsho	2509	2	previously	previously	RB
cord-006229-7yoilsho	2509	3	demonstrated	demonstrate	VBD
cord-006229-7yoilsho	2509	4	that	that	IN
cord-006229-7yoilsho	2509	5	the	the	DT
cord-006229-7yoilsho	2509	6	Krüppel	Krüppel	NNP
cord-006229-7yoilsho	2509	7	-	-	HYPH
cord-006229-7yoilsho	2509	8	like	like	IN
cord-006229-7yoilsho	2509	9	-	-	HYPH
cord-006229-7yoilsho	2509	10	factor	factor	NN
cord-006229-7yoilsho	2509	11	15	15	CD
cord-006229-7yoilsho	2509	12	(	(	-LRB-
cord-006229-7yoilsho	2509	13	KLF15	KLF15	NNP
cord-006229-7yoilsho	2509	14	)	)	-RRB-
cord-006229-7yoilsho	2509	15	is	be	VBZ
cord-006229-7yoilsho	2509	16	a	a	DT
cord-006229-7yoilsho	2509	17	βcatenin	βcatenin	NNP
cord-006229-7yoilsho	2509	18	interaction	interaction	NN
cord-006229-7yoilsho	2509	19	partner	partner	NN
cord-006229-7yoilsho	2509	20	and	and	CC
cord-006229-7yoilsho	2509	21	a	a	DT
cord-006229-7yoilsho	2509	22	cardiac	cardiac	JJ
cord-006229-7yoilsho	2509	23	specific	specific	JJ
cord-006229-7yoilsho	2509	24	nuclear	nuclear	JJ
cord-006229-7yoilsho	2509	25	inhibitor	inhibitor	NN
cord-006229-7yoilsho	2509	26	of	of	IN
cord-006229-7yoilsho	2509	27	the	the	DT
cord-006229-7yoilsho	2509	28	Wnt	Wnt	NNP
cord-006229-7yoilsho	2509	29	/	/	SYM
cord-006229-7yoilsho	2509	30	β	β	NN
cord-006229-7yoilsho	2509	31	-	-	HYPH
cord-006229-7yoilsho	2509	32	catenindependent	catenindependent	NN
cord-006229-7yoilsho	2509	33	transcription	transcription	NN
cord-006229-7yoilsho	2509	34	.	.	.
cord-006229-7yoilsho	2510	1	Because	because	IN
cord-006229-7yoilsho	2510	2	KLF15	KLF15	NNP
cord-006229-7yoilsho	2510	3	and	and	CC
cord-006229-7yoilsho	2510	4	β	β	NN
cord-006229-7yoilsho	2510	5	-	-	HYPH
cord-006229-7yoilsho	2510	6	catenin	catenin	NNP
cord-006229-7yoilsho	2510	7	are	be	VBP
cord-006229-7yoilsho	2510	8	ubiquitously	ubiquitously	RB
cord-006229-7yoilsho	2510	9	expressed	express	VBN
cord-006229-7yoilsho	2510	10	,	,	,
cord-006229-7yoilsho	2510	11	we	-PRON-	PRP
cord-006229-7yoilsho	2510	12	suggest	suggest	VBP
cord-006229-7yoilsho	2510	13	the	the	DT
cord-006229-7yoilsho	2510	14	existence	existence	NN
cord-006229-7yoilsho	2510	15	of	of	IN
cord-006229-7yoilsho	2510	16	cardiac	cardiac	JJ
cord-006229-7yoilsho	2510	17	specific	specific	JJ
cord-006229-7yoilsho	2510	18	co	co	NNS
cord-006229-7yoilsho	2510	19	-	-	NNS
cord-006229-7yoilsho	2510	20	factors	factor	NNS
cord-006229-7yoilsho	2510	21	responsible	responsible	JJ
cord-006229-7yoilsho	2510	22	for	for	IN
cord-006229-7yoilsho	2510	23	cardiac	cardiac	JJ
cord-006229-7yoilsho	2510	24	specificity	specificity	NN
cord-006229-7yoilsho	2510	25	in	in	IN
cord-006229-7yoilsho	2510	26	this	this	DT
cord-006229-7yoilsho	2510	27	complex	complex	NN
cord-006229-7yoilsho	2510	28	.	.	.
cord-006229-7yoilsho	2511	1	We	-PRON-	PRP
cord-006229-7yoilsho	2511	2	identified	identify	VBD
cord-006229-7yoilsho	2511	3	the	the	DT
cord-006229-7yoilsho	2511	4	Basic	basic	JJ
cord-006229-7yoilsho	2511	5	leucine	leucine	NN
cord-006229-7yoilsho	2511	6	Zipper	Zipper	NNP
cord-006229-7yoilsho	2511	7	and	and	CC
cord-006229-7yoilsho	2511	8	W2	W2	NNP
cord-006229-7yoilsho	2511	9	domain	domain	NN
cord-006229-7yoilsho	2511	10	containing	contain	VBG
cord-006229-7yoilsho	2511	11	protein	protein	NN
cord-006229-7yoilsho	2511	12	2	2	CD
cord-006229-7yoilsho	2511	13	(	(	-LRB-
cord-006229-7yoilsho	2511	14	BZW2	BZW2	NNP
cord-006229-7yoilsho	2511	15	)	)	-RRB-
cord-006229-7yoilsho	2511	16	,	,	,
cord-006229-7yoilsho	2511	17	a	a	DT
cord-006229-7yoilsho	2511	18	phylogenetically	phylogenetically	RB
cord-006229-7yoilsho	2511	19	conserved	conserve	VBN
cord-006229-7yoilsho	2511	20	protein	protein	NN
cord-006229-7yoilsho	2511	21	,	,	,
cord-006229-7yoilsho	2511	22	as	as	IN
cord-006229-7yoilsho	2511	23	a	a	DT
cord-006229-7yoilsho	2511	24	β	β	NN
cord-006229-7yoilsho	2511	25	-	-	HYPH
cord-006229-7yoilsho	2511	26	catenin	catenin	NNS
cord-006229-7yoilsho	2511	27	and	and	CC
cord-006229-7yoilsho	2511	28	KLF15	KLF15	NNP
cord-006229-7yoilsho	2511	29	interaction	interaction	NN
cord-006229-7yoilsho	2511	30	partner	partner	NN
cord-006229-7yoilsho	2511	31	using	use	VBG
cord-006229-7yoilsho	2511	32	yeast	yeast	NN
cord-006229-7yoilsho	2511	33	-	-	HYPH
cord-006229-7yoilsho	2511	34	two	two	CD
cord-006229-7yoilsho	2511	35	-	-	HYPH
cord-006229-7yoilsho	2511	36	hybrid	hybrid	NN
cord-006229-7yoilsho	2511	37	screen	screen	NN
cord-006229-7yoilsho	2511	38	.	.	.
cord-006229-7yoilsho	2512	1	In	in	IN
cord-006229-7yoilsho	2512	2	vitro	vitro	FW
cord-006229-7yoilsho	2512	3	overexpression	overexpression	NN
cord-006229-7yoilsho	2512	4	experiments	experiment	NNS
cord-006229-7yoilsho	2512	5	and	and	CC
cord-006229-7yoilsho	2512	6	coimmunoprecipitation	coimmunoprecipitation	NN
cord-006229-7yoilsho	2512	7	validated	validate	VBD
cord-006229-7yoilsho	2512	8	these	these	DT
cord-006229-7yoilsho	2512	9	interactions	interaction	NNS
cord-006229-7yoilsho	2512	10	,	,	,
cord-006229-7yoilsho	2512	11	which	which	WDT
cord-006229-7yoilsho	2512	12	were	be	VBD
cord-006229-7yoilsho	2512	13	also	also	RB
cord-006229-7yoilsho	2512	14	confirmed	confirm	VBN
cord-006229-7yoilsho	2512	15	by	by	IN
cord-006229-7yoilsho	2512	16	mass	mass	NN
cord-006229-7yoilsho	2512	17	spectrometry	spectrometry	NN
cord-006229-7yoilsho	2512	18	.	.	.
cord-006229-7yoilsho	2513	1	In	in	IN
cord-006229-7yoilsho	2513	2	the	the	DT
cord-006229-7yoilsho	2513	3	developing	develop	VBG
cord-006229-7yoilsho	2513	4	mouse	mouse	NN
cord-006229-7yoilsho	2513	5	embryo	embryo	NN
cord-006229-7yoilsho	2513	6	BZW2	BZW2	NNP
cord-006229-7yoilsho	2513	7	mRNA	mRNA	NNP
cord-006229-7yoilsho	2513	8	expression	expression	NN
cord-006229-7yoilsho	2513	9	is	be	VBZ
cord-006229-7yoilsho	2513	10	detectable	detectable	JJ
cord-006229-7yoilsho	2513	11	in	in	IN
cord-006229-7yoilsho	2513	12	the	the	DT
cord-006229-7yoilsho	2513	13	heart	heart	NN
cord-006229-7yoilsho	2513	14	,	,	,
cord-006229-7yoilsho	2513	15	neuronal	neuronal	JJ
cord-006229-7yoilsho	2513	16	tissue	tissue	NN
cord-006229-7yoilsho	2513	17	,	,	,
cord-006229-7yoilsho	2513	18	somites	somite	NNS
cord-006229-7yoilsho	2513	19	,	,	,
cord-006229-7yoilsho	2513	20	limbs	limb	NNS
cord-006229-7yoilsho	2513	21	and	and	CC
cord-006229-7yoilsho	2513	22	branchial	branchial	JJ
cord-006229-7yoilsho	2513	23	arches	arch	NNS
cord-006229-7yoilsho	2513	24	as	as	IN
cord-006229-7yoilsho	2513	25	shown	show	VBN
cord-006229-7yoilsho	2513	26	by	by	IN
cord-006229-7yoilsho	2513	27	whole	whole	JJ
cord-006229-7yoilsho	2513	28	mount	mount	NN
cord-006229-7yoilsho	2513	29	in	in	IN
cord-006229-7yoilsho	2513	30	situ	situ	NN
cord-006229-7yoilsho	2513	31	hybridization	hybridization	NN
cord-006229-7yoilsho	2513	32	.	.	.
cord-006229-7yoilsho	2514	1	In	in	IN
cord-006229-7yoilsho	2514	2	the	the	DT
cord-006229-7yoilsho	2514	3	adulthood	adulthood	JJ
cord-006229-7yoilsho	2514	4	expression	expression	NN
cord-006229-7yoilsho	2514	5	of	of	IN
cord-006229-7yoilsho	2514	6	BZW2	BZW2	NNP
cord-006229-7yoilsho	2514	7	is	be	VBZ
cord-006229-7yoilsho	2514	8	confined	confine	VBN
cord-006229-7yoilsho	2514	9	to	to	IN
cord-006229-7yoilsho	2514	10	the	the	DT
cord-006229-7yoilsho	2514	11	heart	heart	NN
cord-006229-7yoilsho	2514	12	,	,	,
cord-006229-7yoilsho	2514	13	predominantly	predominantly	RB
cord-006229-7yoilsho	2514	14	in	in	IN
cord-006229-7yoilsho	2514	15	cardiomyocytes	cardiomyocyte	NNS
cord-006229-7yoilsho	2514	16	and	and	CC
cord-006229-7yoilsho	2514	17	in	in	IN
cord-006229-7yoilsho	2514	18	cardiac	cardiac	JJ
cord-006229-7yoilsho	2514	19	progenitor	progenitor	NN
cord-006229-7yoilsho	2514	20	cells	cell	NNS
cord-006229-7yoilsho	2514	21	compared	compare	VBN
cord-006229-7yoilsho	2514	22	to	to	IN
cord-006229-7yoilsho	2514	23	cardiac	cardiac	JJ
cord-006229-7yoilsho	2514	24	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	2514	25	(	(	-LRB-
cord-006229-7yoilsho	2514	26	*	*	NFP
cord-006229-7yoilsho	2514	27	p<0.05	p<0.05	NNP
cord-006229-7yoilsho	2514	28	,	,	,
cord-006229-7yoilsho	2514	29	CM	CM	NNP
cord-006229-7yoilsho	2514	30	n=4	n=4	NNS
cord-006229-7yoilsho	2514	31	,	,	,
cord-006229-7yoilsho	2514	32	cFB	cFB	NNP
cord-006229-7yoilsho	2514	33	n=4	n=4	NNS
cord-006229-7yoilsho	2514	34	,	,	,
cord-006229-7yoilsho	2514	35	CPC	CPC	NNP
cord-006229-7yoilsho	2514	36	n=2	n=2	NNS
cord-006229-7yoilsho	2514	37	)	)	-RRB-
cord-006229-7yoilsho	2514	38	,	,	,
cord-006229-7yoilsho	2514	39	and	and	CC
cord-006229-7yoilsho	2514	40	skeletal	skeletal	JJ
cord-006229-7yoilsho	2514	41	muscle	muscle	NN
cord-006229-7yoilsho	2514	42	.	.	.
cord-006229-7yoilsho	2515	1	BZW2	BZW2	NNP
cord-006229-7yoilsho	2515	2	was	be	VBD
cord-006229-7yoilsho	2515	3	localized	localize	VBN
cord-006229-7yoilsho	2515	4	in	in	IN
cord-006229-7yoilsho	2515	5	both	both	CC
cord-006229-7yoilsho	2515	6	the	the	DT
cord-006229-7yoilsho	2515	7	cytosol	cytosol	NN
cord-006229-7yoilsho	2515	8	and	and	CC
cord-006229-7yoilsho	2515	9	in	in	IN
cord-006229-7yoilsho	2515	10	the	the	DT
cord-006229-7yoilsho	2515	11	nucleus	nucleus	NN
cord-006229-7yoilsho	2515	12	.	.	.
cord-006229-7yoilsho	2516	1	Mutation	mutation	NN
cord-006229-7yoilsho	2516	2	analysis	analysis	NN
cord-006229-7yoilsho	2516	3	showed	show	VBD
cord-006229-7yoilsho	2516	4	the	the	DT
cord-006229-7yoilsho	2516	5	importance	importance	NN
cord-006229-7yoilsho	2516	6	of	of	IN
cord-006229-7yoilsho	2516	7	the	the	DT
cord-006229-7yoilsho	2516	8	N	n	CD
cord-006229-7yoilsho	2516	9	-	-	HYPH
cord-006229-7yoilsho	2516	10	terminus	terminus	NN
cord-006229-7yoilsho	2516	11	of	of	IN
cord-006229-7yoilsho	2516	12	BZW2	BZW2	NNP
cord-006229-7yoilsho	2516	13	,	,	,
cord-006229-7yoilsho	2516	14	containing	contain	VBG
cord-006229-7yoilsho	2516	15	a	a	DT
cord-006229-7yoilsho	2516	16	putative	putative	JJ
cord-006229-7yoilsho	2516	17	bZip	bZip	NNP
cord-006229-7yoilsho	2516	18	DNA	dna	NN
cord-006229-7yoilsho	2516	19	interaction	interaction	NN
cord-006229-7yoilsho	2516	20	domain	domain	NN
cord-006229-7yoilsho	2516	21	,	,	,
cord-006229-7yoilsho	2516	22	for	for	IN
cord-006229-7yoilsho	2516	23	the	the	DT
cord-006229-7yoilsho	2516	24	nuclear	nuclear	JJ
cord-006229-7yoilsho	2516	25	placement	placement	NN
cord-006229-7yoilsho	2516	26	of	of	IN
cord-006229-7yoilsho	2516	27	the	the	DT
cord-006229-7yoilsho	2516	28	protein	protein	NN
cord-006229-7yoilsho	2516	29	.	.	.
cord-006229-7yoilsho	2517	1	BZW2	BZW2	NNP
cord-006229-7yoilsho	2517	2	protein	protein	NN
cord-006229-7yoilsho	2517	3	expression	expression	NN
cord-006229-7yoilsho	2517	4	was	be	VBD
cord-006229-7yoilsho	2517	5	significantly	significantly	RB
cord-006229-7yoilsho	2517	6	increased	increase	VBN
cord-006229-7yoilsho	2517	7	under	under	IN
cord-006229-7yoilsho	2517	8	cardiac	cardiac	JJ
cord-006229-7yoilsho	2517	9	Wnt	Wnt	NNP
cord-006229-7yoilsho	2517	10	/	/	SYM
cord-006229-7yoilsho	2517	11	β	β	NNP
cord-006229-7yoilsho	2517	12	-	-	HYPH
cord-006229-7yoilsho	2517	13	catenin	catenin	NNP
cord-006229-7yoilsho	2517	14	signaling	signal	VBG
cord-006229-7yoilsho	2517	15	activation	activation	NN
cord-006229-7yoilsho	2517	16	in	in	IN
cord-006229-7yoilsho	2517	17	vivo	vivo	NN
cord-006229-7yoilsho	2517	18	in	in	IN
cord-006229-7yoilsho	2517	19	two	two	CD
cord-006229-7yoilsho	2517	20	mouse	mouse	NN
cord-006229-7yoilsho	2517	21	models	model	NNS
cord-006229-7yoilsho	2517	22	(	(	-LRB-
cord-006229-7yoilsho	2517	23	KLF15	KLF15	NNP
cord-006229-7yoilsho	2517	24	knockout	knockout	NN
cord-006229-7yoilsho	2517	25	(	(	-LRB-
cord-006229-7yoilsho	2517	26	KO	KO	NNP
cord-006229-7yoilsho	2517	27	)	)	-RRB-
cord-006229-7yoilsho	2517	28	mice	mouse	NNS
cord-006229-7yoilsho	2517	29	*	*	NFP
cord-006229-7yoilsho	2517	30	*	*	NFP
cord-006229-7yoilsho	2517	31	p<0.01	p<0.01	JJ
cord-006229-7yoilsho	2517	32	n=3	n=3	RB
cord-006229-7yoilsho	2517	33	,	,	,
cord-006229-7yoilsho	2517	34	and	and	CC
cord-006229-7yoilsho	2517	35	in	in	IN
cord-006229-7yoilsho	2517	36	a	a	DT
cord-006229-7yoilsho	2517	37	cardiac	cardiac	JJ
cord-006229-7yoilsho	2517	38	specific	specific	JJ
cord-006229-7yoilsho	2517	39	β	β	NN
cord-006229-7yoilsho	2517	40	-	-	HYPH
cord-006229-7yoilsho	2517	41	catenin	catenin	NNP
cord-006229-7yoilsho	2517	42	stabilized	stabilize	VBD
cord-006229-7yoilsho	2517	43	mouse	mouse	NN
cord-006229-7yoilsho	2517	44	model	model	NN
cord-006229-7yoilsho	2517	45	,	,	,
cord-006229-7yoilsho	2517	46	*	*	NFP
cord-006229-7yoilsho	2517	47	*	*	NFP
cord-006229-7yoilsho	2517	48	p<0.01	p<0.01	NNP
cord-006229-7yoilsho	2517	49	n=6	n=6	NNP
cord-006229-7yoilsho	2517	50	)	)	-RRB-
cord-006229-7yoilsho	2517	51	.	.	.
cord-006229-7yoilsho	2518	1	A	a	DT
cord-006229-7yoilsho	2518	2	mouse	mouse	NN
cord-006229-7yoilsho	2518	3	model	model	NN
cord-006229-7yoilsho	2518	4	with	with	IN
cord-006229-7yoilsho	2518	5	constitutively	constitutively	RB
cord-006229-7yoilsho	2518	6	BZW2	BZW2	NNP
cord-006229-7yoilsho	2518	7	loss	loss	NN
cord-006229-7yoilsho	2518	8	of	of	IN
cord-006229-7yoilsho	2518	9	function	function	NN
cord-006229-7yoilsho	2519	1	(	(	-LRB-
cord-006229-7yoilsho	2519	2	BZW2	BZW2	NNP
cord-006229-7yoilsho	2519	3	KO	KO	NNP
cord-006229-7yoilsho	2519	4	)	)	-RRB-
cord-006229-7yoilsho	2519	5	showed	show	VBD
cord-006229-7yoilsho	2519	6	cardiac	cardiac	JJ
cord-006229-7yoilsho	2519	7	specific	specific	JJ
cord-006229-7yoilsho	2519	8	upregulation	upregulation	NN
cord-006229-7yoilsho	2519	9	of	of	IN
cord-006229-7yoilsho	2519	10	β	β	NN
cord-006229-7yoilsho	2519	11	-	-	HYPH
cord-006229-7yoilsho	2519	12	catenin	catenin	NNP
cord-006229-7yoilsho	2519	13	on	on	IN
cord-006229-7yoilsho	2519	14	RNA	RNA	NNP
cord-006229-7yoilsho	2519	15	level	level	NN
cord-006229-7yoilsho	2519	16	(	(	-LRB-
cord-006229-7yoilsho	2520	1	*	*	NFP
cord-006229-7yoilsho	2520	2	*	*	NFP
cord-006229-7yoilsho	2520	3	*	*	NFP
cord-006229-7yoilsho	2520	4	p<0.001	p<0.001	CD
cord-006229-7yoilsho	2520	5	,	,	,
cord-006229-7yoilsho	2520	6	p<0.05	p<0.05	NNP
cord-006229-7yoilsho	2520	7	,	,	,
cord-006229-7yoilsho	2520	8	ctrl	ctrl	VB
cord-006229-7yoilsho	2520	9	n=4	n=4	NNS
cord-006229-7yoilsho	2520	10	,	,	,
cord-006229-7yoilsho	2520	11	BZW2	BZW2	NNP
cord-006229-7yoilsho	2520	12	KO	KO	NNP
cord-006229-7yoilsho	2520	13	n=5	n=5	RB
cord-006229-7yoilsho	2520	14	)	)	-RRB-
cord-006229-7yoilsho	2521	1	and	and	CC
cord-006229-7yoilsho	2521	2	on	on	IN
cord-006229-7yoilsho	2521	3	protein	protein	NN
cord-006229-7yoilsho	2521	4	level	level	NN
cord-006229-7yoilsho	2521	5	(	(	-LRB-
cord-006229-7yoilsho	2521	6	*	*	NFP
cord-006229-7yoilsho	2521	7	*	*	NFP
cord-006229-7yoilsho	2521	8	p<0.05	p<0.05	XX
cord-006229-7yoilsho	2521	9	,	,	,
cord-006229-7yoilsho	2521	10	ctrl	ctrl	VB
cord-006229-7yoilsho	2521	11	n=7	n=7	NNS
cord-006229-7yoilsho	2521	12	,	,	,
cord-006229-7yoilsho	2521	13	BZW2	BZW2	NNP
cord-006229-7yoilsho	2521	14	KO	KO	NNP
cord-006229-7yoilsho	2521	15	n=9	n=9	NN
cord-006229-7yoilsho	2521	16	)	)	-RRB-
cord-006229-7yoilsho	2521	17	.	.	.
cord-006229-7yoilsho	2522	1	Echocardiography	echocardiography	NN
cord-006229-7yoilsho	2522	2	analysis	analysis	NN
cord-006229-7yoilsho	2522	3	in	in	IN
cord-006229-7yoilsho	2522	4	eight	eight	CD
cord-006229-7yoilsho	2522	5	-	-	HYPH
cord-006229-7yoilsho	2522	6	weeks	week	NNS
cord-006229-7yoilsho	2522	7	-	-	HYPH
cord-006229-7yoilsho	2522	8	old	old	JJ
cord-006229-7yoilsho	2522	9	BZW2	BZW2	NNP
cord-006229-7yoilsho	2522	10	KO	KO	NNP
cord-006229-7yoilsho	2522	11	mice	mouse	NNS
cord-006229-7yoilsho	2522	12	showed	show	VBD
cord-006229-7yoilsho	2522	13	increased	increase	VBN
cord-006229-7yoilsho	2522	14	left	left	JJ
cord-006229-7yoilsho	2522	15	ventricle	ventricle	NN
cord-006229-7yoilsho	2522	16	wall	wall	NN
cord-006229-7yoilsho	2522	17	thickness	thickness	NN
cord-006229-7yoilsho	2522	18	indicating	indicate	VBG
cord-006229-7yoilsho	2522	19	a	a	DT
cord-006229-7yoilsho	2522	20	hypertrophic	hypertrophic	JJ
cord-006229-7yoilsho	2522	21	phenotype	phenotype	NN
cord-006229-7yoilsho	2522	22	at	at	IN
cord-006229-7yoilsho	2522	23	baseline	baseline	NN
cord-006229-7yoilsho	2522	24	.	.	.
cord-006229-7yoilsho	2523	1	We	-PRON-	PRP
cord-006229-7yoilsho	2523	2	also	also	RB
cord-006229-7yoilsho	2523	3	observed	observe	VBD
cord-006229-7yoilsho	2523	4	increased	increase	VBN
cord-006229-7yoilsho	2523	5	levels	level	NNS
cord-006229-7yoilsho	2523	6	of	of	IN
cord-006229-7yoilsho	2523	7	BZW2	BZW2	NNP
cord-006229-7yoilsho	2523	8	expression	expression	NN
cord-006229-7yoilsho	2523	9	in	in	IN
cord-006229-7yoilsho	2523	10	Angiotensin	Angiotensin	NNP
cord-006229-7yoilsho	2523	11	II	II	NNP
cord-006229-7yoilsho	2523	12	treated	treat	VBD
cord-006229-7yoilsho	2523	13	mice	mouse	NNS
cord-006229-7yoilsho	2523	14	as	as	IN
cord-006229-7yoilsho	2523	15	a	a	DT
cord-006229-7yoilsho	2523	16	model	model	NN
cord-006229-7yoilsho	2523	17	for	for	IN
cord-006229-7yoilsho	2523	18	cardiac	cardiac	JJ
cord-006229-7yoilsho	2523	19	hypertrophy	hypertrophy	NN
cord-006229-7yoilsho	2523	20	(	(	-LRB-
cord-006229-7yoilsho	2523	21	*	*	NFP
cord-006229-7yoilsho	2523	22	p<0.05	p<0.05	JJ
cord-006229-7yoilsho	2523	23	ctrl	ctrl	NN
cord-006229-7yoilsho	2523	24	n=4	n=4	NNS
cord-006229-7yoilsho	2523	25	,	,	,
cord-006229-7yoilsho	2523	26	AngII	AngII	NNP
cord-006229-7yoilsho	2523	27	n=3	n=3	RB
cord-006229-7yoilsho	2523	28	)	)	-RRB-
cord-006229-7yoilsho	2523	29	as	as	RB
cord-006229-7yoilsho	2523	30	well	well	RB
cord-006229-7yoilsho	2523	31	as	as	IN
cord-006229-7yoilsho	2523	32	in	in	IN
cord-006229-7yoilsho	2523	33	human	human	JJ
cord-006229-7yoilsho	2523	34	samples	sample	NNS
cord-006229-7yoilsho	2523	35	derived	derive	VBN
cord-006229-7yoilsho	2523	36	from	from	IN
cord-006229-7yoilsho	2523	37	patients	patient	NNS
cord-006229-7yoilsho	2523	38	with	with	IN
cord-006229-7yoilsho	2523	39	dilated	dilated	JJ
cord-006229-7yoilsho	2523	40	cardiomyopathy	cardiomyopathy	NN
cord-006229-7yoilsho	2523	41	and	and	CC
cord-006229-7yoilsho	2523	42	ischemic	ischemic	JJ
cord-006229-7yoilsho	2523	43	cardiomyopathy	cardiomyopathy	NN
cord-006229-7yoilsho	2524	1	(	(	-LRB-
cord-006229-7yoilsho	2524	2	*	*	NFP
cord-006229-7yoilsho	2524	3	p<0.05	p<0.05	JJ
cord-006229-7yoilsho	2524	4	ctrl	ctrl	NN
cord-006229-7yoilsho	2524	5	n=3	n=3	NN
cord-006229-7yoilsho	2524	6	,	,	,
cord-006229-7yoilsho	2524	7	DCM	DCM	NNP
cord-006229-7yoilsho	2524	8	n=11	n=11	NNP
cord-006229-7yoilsho	2524	9	,	,	,
cord-006229-7yoilsho	2524	10	ICM	ICM	NNP
cord-006229-7yoilsho	2524	11	n=10	n=10	NNP
cord-006229-7yoilsho	2524	12	)	)	-RRB-
cord-006229-7yoilsho	2524	13	.	.	.
cord-006229-7yoilsho	2525	1	Conclusion	conclusion	NN
cord-006229-7yoilsho	2525	2	:	:	:
cord-006229-7yoilsho	2526	1	These	these	DT
cord-006229-7yoilsho	2526	2	data	datum	NNS
cord-006229-7yoilsho	2526	3	demonstrated	demonstrate	VBD
cord-006229-7yoilsho	2526	4	that	that	IN
cord-006229-7yoilsho	2526	5	BZW2	BZW2	NNP
cord-006229-7yoilsho	2526	6	is	be	VBZ
cord-006229-7yoilsho	2526	7	associated	associate	VBN
cord-006229-7yoilsho	2526	8	with	with	IN
cord-006229-7yoilsho	2526	9	components	component	NNS
cord-006229-7yoilsho	2526	10	of	of	IN
cord-006229-7yoilsho	2526	11	the	the	DT
cord-006229-7yoilsho	2526	12	canonical	canonical	JJ
cord-006229-7yoilsho	2526	13	Wnt	Wnt	NNP
cord-006229-7yoilsho	2526	14	cascade	cascade	VB
cord-006229-7yoilsho	2526	15	and	and	CC
cord-006229-7yoilsho	2526	16	suggest	suggest	VB
cord-006229-7yoilsho	2526	17	its	-PRON-	PRP$
cord-006229-7yoilsho	2526	18	relevance	relevance	NN
cord-006229-7yoilsho	2526	19	in	in	IN
cord-006229-7yoilsho	2526	20	the	the	DT
cord-006229-7yoilsho	2526	21	constitutive	constitutive	JJ
cord-006229-7yoilsho	2526	22	regulation	regulation	NN
cord-006229-7yoilsho	2526	23	of	of	IN
cord-006229-7yoilsho	2526	24	the	the	DT
cord-006229-7yoilsho	2526	25	Wnt	Wnt	NNP
cord-006229-7yoilsho	2526	26	/	/	SYM
cord-006229-7yoilsho	2526	27	β	β	NNP
cord-006229-7yoilsho	2526	28	-	-	HYPH
cord-006229-7yoilsho	2526	29	catenin	catenin	NN
cord-006229-7yoilsho	2526	30	components	component	NNS
cord-006229-7yoilsho	2526	31	specific	specific	JJ
cord-006229-7yoilsho	2526	32	in	in	IN
cord-006229-7yoilsho	2526	33	the	the	DT
cord-006229-7yoilsho	2526	34	heart	heart	NN
cord-006229-7yoilsho	2526	35	.	.	.
cord-006229-7yoilsho	2527	1	This	this	DT
cord-006229-7yoilsho	2527	2	study	study	NN
cord-006229-7yoilsho	2527	3	further	further	RB
cord-006229-7yoilsho	2527	4	contribute	contribute	VBP
cord-006229-7yoilsho	2527	5	to	to	IN
cord-006229-7yoilsho	2527	6	the	the	DT
cord-006229-7yoilsho	2527	7	elucidation	elucidation	NN
cord-006229-7yoilsho	2527	8	of	of	IN
cord-006229-7yoilsho	2527	9	the	the	DT
cord-006229-7yoilsho	2527	10	tuning	tuning	NN
cord-006229-7yoilsho	2527	11	of	of	IN
cord-006229-7yoilsho	2527	12	the	the	DT
cord-006229-7yoilsho	2527	13	Wnt	Wnt	NNP
cord-006229-7yoilsho	2527	14	-	-	HYPH
cord-006229-7yoilsho	2527	15	off/-on	off/-on	NNP
cord-006229-7yoilsho	2527	16	states	state	NNS
cord-006229-7yoilsho	2527	17	aiming	aim	VBG
cord-006229-7yoilsho	2527	18	to	to	TO
cord-006229-7yoilsho	2527	19	establish	establish	VB
cord-006229-7yoilsho	2527	20	a	a	DT
cord-006229-7yoilsho	2527	21	proof	proof	NN
cord-006229-7yoilsho	2527	22	-	-	HYPH
cord-006229-7yoilsho	2527	23	of	of	IN
cord-006229-7yoilsho	2527	24	-	-	HYPH
cord-006229-7yoilsho	2527	25	concept	concept	NN
cord-006229-7yoilsho	2527	26	model	model	NN
cord-006229-7yoilsho	2527	27	for	for	IN
cord-006229-7yoilsho	2527	28	Wnt	wnt	NN
cord-006229-7yoilsho	2527	29	-	-	HYPH
cord-006229-7yoilsho	2527	30	modulation	modulation	NN
cord-006229-7yoilsho	2527	31	as	as	IN
cord-006229-7yoilsho	2527	32	a	a	DT
cord-006229-7yoilsho	2527	33	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	2527	34	strategy	strategy	NN
cord-006229-7yoilsho	2527	35	in	in	IN
cord-006229-7yoilsho	2527	36	hypertrophic	hypertrophic	NN
cord-006229-7yoilsho	2527	37	-	-	HYPH
cord-006229-7yoilsho	2527	38	induced	induce	VBN
cord-006229-7yoilsho	2527	39	heart	heart	NN
cord-006229-7yoilsho	2527	40	failure	failure	NN
cord-006229-7yoilsho	2527	41	.	.	.
cord-006229-7yoilsho	2528	1	Objective	objective	JJ
cord-006229-7yoilsho	2528	2	:	:	:
cord-006229-7yoilsho	2528	3	Sphingosine-1-phosphate	Sphingosine-1-phosphate	NNP
cord-006229-7yoilsho	2528	4	(	(	-LRB-
cord-006229-7yoilsho	2528	5	S1P	s1p	NN
cord-006229-7yoilsho	2528	6	)	)	-RRB-
cord-006229-7yoilsho	2529	1	is	be	VBZ
cord-006229-7yoilsho	2529	2	involved	involve	VBN
cord-006229-7yoilsho	2529	3	in	in	IN
cord-006229-7yoilsho	2529	4	the	the	DT
cord-006229-7yoilsho	2529	5	regulation	regulation	NN
cord-006229-7yoilsho	2529	6	of	of	IN
cord-006229-7yoilsho	2529	7	cell	cell	NN
cord-006229-7yoilsho	2529	8	growth	growth	NN
cord-006229-7yoilsho	2529	9	,	,	,
cord-006229-7yoilsho	2529	10	survival	survival	NN
cord-006229-7yoilsho	2529	11	,	,	,
cord-006229-7yoilsho	2529	12	migration	migration	NN
cord-006229-7yoilsho	2529	13	and	and	CC
cord-006229-7yoilsho	2529	14	adhesion	adhesion	NN
cord-006229-7yoilsho	2529	15	.	.	.
cord-006229-7yoilsho	2530	1	It	-PRON-	PRP
cord-006229-7yoilsho	2530	2	is	be	VBZ
cord-006229-7yoilsho	2530	3	formed	form	VBN
cord-006229-7yoilsho	2530	4	by	by	IN
cord-006229-7yoilsho	2530	5	sphingosine	sphingosine	NNP
cord-006229-7yoilsho	2530	6	kinases	kinase	NNS
cord-006229-7yoilsho	2530	7	and	and	CC
cord-006229-7yoilsho	2530	8	degraded	degrade	VBN
cord-006229-7yoilsho	2530	9	by	by	IN
cord-006229-7yoilsho	2530	10	phosphatases	phosphatase	NNS
cord-006229-7yoilsho	2530	11	and	and	CC
cord-006229-7yoilsho	2530	12	S1P	s1p	NN
cord-006229-7yoilsho	2530	13	lyase	lyase	NN
cord-006229-7yoilsho	2530	14	[	[	-LRB-
cord-006229-7yoilsho	2530	15	1	1	CD
cord-006229-7yoilsho	2530	16	]	]	-RRB-
cord-006229-7yoilsho	2530	17	.	.	.
cord-006229-7yoilsho	2531	1	Mice	mouse	NNS
cord-006229-7yoilsho	2531	2	that	that	IN
cord-006229-7yoilsho	2531	3	lack	lack	VBP
cord-006229-7yoilsho	2531	4	S1P	s1p	CD
cord-006229-7yoilsho	2531	5	lyase	lyase	NN
cord-006229-7yoilsho	2531	6	are	be	VBP
cord-006229-7yoilsho	2531	7	characterized	characterize	VBN
cord-006229-7yoilsho	2531	8	by	by	IN
cord-006229-7yoilsho	2531	9	the	the	DT
cord-006229-7yoilsho	2531	10	accumulation	accumulation	NN
cord-006229-7yoilsho	2531	11	of	of	IN
cord-006229-7yoilsho	2531	12	S1P	s1p	NN
cord-006229-7yoilsho	2531	13	and	and	CC
cord-006229-7yoilsho	2531	14	sphingosine	sphingosine	VB
cord-006229-7yoilsho	2531	15	in	in	IN
cord-006229-7yoilsho	2531	16	their	-PRON-	PRP$
cord-006229-7yoilsho	2531	17	cells	cell	NNS
cord-006229-7yoilsho	2531	18	and	and	CC
cord-006229-7yoilsho	2531	19	tissues	tissue	NNS
cord-006229-7yoilsho	2531	20	,	,	,
cord-006229-7yoilsho	2531	21	and	and	CC
cord-006229-7yoilsho	2531	22	by	by	IN
cord-006229-7yoilsho	2531	23	lymphopenia	lymphopenia	NNP
cord-006229-7yoilsho	2531	24	,	,	,
cord-006229-7yoilsho	2531	25	generalized	generalized	JJ
cord-006229-7yoilsho	2531	26	inflammation	inflammation	NN
cord-006229-7yoilsho	2531	27	,	,	,
cord-006229-7yoilsho	2531	28	multiple	multiple	JJ
cord-006229-7yoilsho	2531	29	organ	organ	NN
cord-006229-7yoilsho	2531	30	damage	damage	NN
cord-006229-7yoilsho	2531	31	,	,	,
cord-006229-7yoilsho	2531	32	and	and	CC
cord-006229-7yoilsho	2531	33	a	a	DT
cord-006229-7yoilsho	2531	34	strongly	strongly	RB
cord-006229-7yoilsho	2531	35	reduced	reduce	VBN
cord-006229-7yoilsho	2531	36	life	life	NN
cord-006229-7yoilsho	2531	37	span	span	NN
cord-006229-7yoilsho	2531	38	[	[	-LRB-
cord-006229-7yoilsho	2531	39	2	2	CD
cord-006229-7yoilsho	2531	40	]	]	-RRB-
cord-006229-7yoilsho	2531	41	[	[	-LRB-
cord-006229-7yoilsho	2531	42	3	3	CD
cord-006229-7yoilsho	2531	43	]	]	-RRB-
cord-006229-7yoilsho	2531	44	[	[	-LRB-
cord-006229-7yoilsho	2531	45	4	4	CD
cord-006229-7yoilsho	2531	46	]	]	-RRB-
cord-006229-7yoilsho	2531	47	.	.	.
cord-006229-7yoilsho	2532	1	On	on	IN
cord-006229-7yoilsho	2532	2	the	the	DT
cord-006229-7yoilsho	2532	3	other	other	JJ
cord-006229-7yoilsho	2532	4	hand	hand	NN
cord-006229-7yoilsho	2532	5	,	,	,
cord-006229-7yoilsho	2532	6	embryonic	embryonic	JJ
cord-006229-7yoilsho	2532	7	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	2532	8	from	from	IN
cord-006229-7yoilsho	2532	9	S1P	s1p	CD
cord-006229-7yoilsho	2532	10	lyase	lyase	NN
cord-006229-7yoilsho	2532	11	-	-	HYPH
cord-006229-7yoilsho	2532	12	deficient	deficient	JJ
cord-006229-7yoilsho	2532	13	mice	mouse	NNS
cord-006229-7yoilsho	2532	14	(	(	-LRB-
cord-006229-7yoilsho	2532	15	Sgpl1	Sgpl1	NNP
cord-006229-7yoilsho	2532	16	-/--MEFs	-/--mefs	SYM
cord-006229-7yoilsho	2532	17	)	)	-RRB-
cord-006229-7yoilsho	2532	18	are	be	VBP
cord-006229-7yoilsho	2532	19	resistant	resistant	JJ
cord-006229-7yoilsho	2532	20	to	to	IN
cord-006229-7yoilsho	2532	21	chemotherapy	chemotherapy	NN
cord-006229-7yoilsho	2532	22	-	-	HYPH
cord-006229-7yoilsho	2532	23	induced	induce	VBN
cord-006229-7yoilsho	2532	24	apoptosis	apoptosis	NN
cord-006229-7yoilsho	2532	25	[	[	-LRB-
cord-006229-7yoilsho	2532	26	5	5	CD
cord-006229-7yoilsho	2532	27	]	]	-RRB-
cord-006229-7yoilsho	2532	28	,	,	,
cord-006229-7yoilsho	2532	29	in	in	IN
cord-006229-7yoilsho	2532	30	part	part	NN
cord-006229-7yoilsho	2532	31	due	due	IN
cord-006229-7yoilsho	2532	32	to	to	IN
cord-006229-7yoilsho	2532	33	an	an	DT
cord-006229-7yoilsho	2532	34	upregulation	upregulation	NN
cord-006229-7yoilsho	2532	35	of	of	IN
cord-006229-7yoilsho	2532	36	multidrug	multidrug	NN
cord-006229-7yoilsho	2532	37	transporters	transporter	NNS
cord-006229-7yoilsho	2532	38	of	of	IN
cord-006229-7yoilsho	2532	39	the	the	DT
cord-006229-7yoilsho	2532	40	ATP	ATP	NNP
cord-006229-7yoilsho	2532	41	-	-	HYPH
cord-006229-7yoilsho	2532	42	binding	bind	VBG
cord-006229-7yoilsho	2532	43	cassette	cassette	NN
cord-006229-7yoilsho	2532	44	(	(	-LRB-
cord-006229-7yoilsho	2532	45	ABC	ABC	NNP
cord-006229-7yoilsho	2532	46	)	)	-RRB-
cord-006229-7yoilsho	2532	47	transporter	transporter	NN
cord-006229-7yoilsho	2532	48	family	family	NN
cord-006229-7yoilsho	2532	49	[	[	-LRB-
cord-006229-7yoilsho	2532	50	6	6	CD
cord-006229-7yoilsho	2532	51	]	]	-RRB-
cord-006229-7yoilsho	2532	52	.	.	.
cord-006229-7yoilsho	2533	1	Interestingly	interestingly	RB
cord-006229-7yoilsho	2533	2	,	,	,
cord-006229-7yoilsho	2533	3	S1P	s1p	CD
cord-006229-7yoilsho	2533	4	lyase	lyase	NN
cord-006229-7yoilsho	2533	5	-	-	HYPH
cord-006229-7yoilsho	2533	6	deficient	deficient	JJ
cord-006229-7yoilsho	2533	7	mice	mouse	NNS
cord-006229-7yoilsho	2533	8	have	have	VBP
cord-006229-7yoilsho	2533	9	elevated	elevate	VBN
cord-006229-7yoilsho	2533	10	plasma	plasma	NN
cord-006229-7yoilsho	2533	11	levels	level	NNS
cord-006229-7yoilsho	2533	12	of	of	IN
cord-006229-7yoilsho	2533	13	cholesterol	cholesterol	NN
cord-006229-7yoilsho	2533	14	and	and	CC
cord-006229-7yoilsho	2533	15	triglycerides	triglyceride	NNS
cord-006229-7yoilsho	2533	16	,	,	,
cord-006229-7yoilsho	2533	17	while	while	IN
cord-006229-7yoilsho	2533	18	suffering	suffer	VBG
cord-006229-7yoilsho	2533	19	from	from	IN
cord-006229-7yoilsho	2533	20	strongly	strongly	RB
cord-006229-7yoilsho	2533	21	reduced	reduce	VBN
cord-006229-7yoilsho	2533	22	body	body	NN
cord-006229-7yoilsho	2533	23	fat	fat	NN
cord-006229-7yoilsho	2533	24	[	[	-LRB-
cord-006229-7yoilsho	2533	25	7	7	CD
cord-006229-7yoilsho	2533	26	]	]	-RRB-
cord-006229-7yoilsho	2533	27	.	.	.
cord-006229-7yoilsho	2534	1	The	the	DT
cord-006229-7yoilsho	2534	2	aim	aim	NN
cord-006229-7yoilsho	2534	3	of	of	IN
cord-006229-7yoilsho	2534	4	the	the	DT
cord-006229-7yoilsho	2534	5	present	present	JJ
cord-006229-7yoilsho	2534	6	study	study	NN
cord-006229-7yoilsho	2534	7	was	be	VBD
cord-006229-7yoilsho	2534	8	to	to	TO
cord-006229-7yoilsho	2534	9	analyze	analyze	VB
cord-006229-7yoilsho	2534	10	the	the	DT
cord-006229-7yoilsho	2534	11	link	link	NN
cord-006229-7yoilsho	2534	12	between	between	IN
cord-006229-7yoilsho	2534	13	S1P	s1p	CD
cord-006229-7yoilsho	2534	14	lyase	lyase	NN
cord-006229-7yoilsho	2534	15	deficiency	deficiency	NN
cord-006229-7yoilsho	2534	16	and	and	CC
cord-006229-7yoilsho	2534	17	altered	alter	VBN
cord-006229-7yoilsho	2534	18	cholesterol	cholesterol	NN
cord-006229-7yoilsho	2534	19	homeostasis	homeostasis	NN
cord-006229-7yoilsho	2534	20	using	use	VBG
cord-006229-7yoilsho	2534	21	Sgpl1	Sgpl1	NNP
cord-006229-7yoilsho	2535	1	Background	background	NN
cord-006229-7yoilsho	2535	2	:	:	:
cord-006229-7yoilsho	2536	1	Cardiac	cardiac	JJ
cord-006229-7yoilsho	2536	2	gene	gene	NN
cord-006229-7yoilsho	2536	3	expression	expression	NN
cord-006229-7yoilsho	2536	4	changes	change	NNS
cord-006229-7yoilsho	2536	5	during	during	IN
cord-006229-7yoilsho	2536	6	cardiac	cardiac	JJ
cord-006229-7yoilsho	2536	7	development	development	NN
cord-006229-7yoilsho	2536	8	and	and	CC
cord-006229-7yoilsho	2536	9	under	under	IN
cord-006229-7yoilsho	2536	10	pathophysiological	pathophysiological	JJ
cord-006229-7yoilsho	2536	11	conditions	condition	NNS
cord-006229-7yoilsho	2536	12	.	.	.
cord-006229-7yoilsho	2537	1	These	these	DT
cord-006229-7yoilsho	2537	2	alterations	alteration	NNS
cord-006229-7yoilsho	2537	3	in	in	IN
cord-006229-7yoilsho	2537	4	gene	gene	NN
cord-006229-7yoilsho	2537	5	expression	expression	NN
cord-006229-7yoilsho	2537	6	are	be	VBP
cord-006229-7yoilsho	2537	7	regulated	regulate	VBN
cord-006229-7yoilsho	2537	8	by	by	IN
cord-006229-7yoilsho	2537	9	several	several	JJ
cord-006229-7yoilsho	2537	10	processes	process	NNS
cord-006229-7yoilsho	2537	11	and	and	CC
cord-006229-7yoilsho	2537	12	the	the	DT
cord-006229-7yoilsho	2537	13	exact	exact	JJ
cord-006229-7yoilsho	2537	14	regulation	regulation	NN
cord-006229-7yoilsho	2537	15	of	of	IN
cord-006229-7yoilsho	2537	16	gene	gene	NN
cord-006229-7yoilsho	2537	17	expression	expression	NN
cord-006229-7yoilsho	2537	18	is	be	VBZ
cord-006229-7yoilsho	2537	19	essential	essential	JJ
cord-006229-7yoilsho	2537	20	for	for	IN
cord-006229-7yoilsho	2537	21	the	the	DT
cord-006229-7yoilsho	2537	22	proper	proper	JJ
cord-006229-7yoilsho	2537	23	development	development	NN
cord-006229-7yoilsho	2537	24	and	and	CC
cord-006229-7yoilsho	2537	25	function	function	NN
cord-006229-7yoilsho	2537	26	of	of	IN
cord-006229-7yoilsho	2537	27	the	the	DT
cord-006229-7yoilsho	2537	28	heart	heart	NN
cord-006229-7yoilsho	2537	29	.	.	.
cord-006229-7yoilsho	2538	1	Crucial	crucial	JJ
cord-006229-7yoilsho	2538	2	steps	step	NNS
cord-006229-7yoilsho	2538	3	in	in	IN
cord-006229-7yoilsho	2538	4	transcription	transcription	NN
cord-006229-7yoilsho	2538	5	regulation	regulation	NN
cord-006229-7yoilsho	2538	6	are	be	VBP
cord-006229-7yoilsho	2538	7	RNA	RNA	NNP
cord-006229-7yoilsho	2538	8	polymerase	polymerase	NN
cord-006229-7yoilsho	2538	9	II	II	NNP
cord-006229-7yoilsho	2538	10	(	(	-LRB-
cord-006229-7yoilsho	2538	11	Pol	Pol	NNP
cord-006229-7yoilsho	2538	12	II	II	NNP
cord-006229-7yoilsho	2538	13	)	)	-RRB-
cord-006229-7yoilsho	2538	14	recruitment	recruitment	NN
cord-006229-7yoilsho	2538	15	and	and	CC
cord-006229-7yoilsho	2538	16	changes	change	NNS
cord-006229-7yoilsho	2538	17	in	in	IN
cord-006229-7yoilsho	2538	18	Pol	Pol	NNP
cord-006229-7yoilsho	2538	19	II	II	NNP
cord-006229-7yoilsho	2538	20	activity	activity	NN
cord-006229-7yoilsho	2538	21	.	.	.
cord-006229-7yoilsho	2539	1	Pol	Pol	NNP
cord-006229-7yoilsho	2539	2	II	II	NNP
cord-006229-7yoilsho	2539	3	activity	activity	NN
cord-006229-7yoilsho	2539	4	is	be	VBZ
cord-006229-7yoilsho	2539	5	tightly	tightly	RB
cord-006229-7yoilsho	2539	6	linked	link	VBN
cord-006229-7yoilsho	2539	7	with	with	IN
cord-006229-7yoilsho	2539	8	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	2539	9	at	at	IN
cord-006229-7yoilsho	2539	10	serine-2	serine-2	NNP
cord-006229-7yoilsho	2540	1	(	(	-LRB-
cord-006229-7yoilsho	2540	2	P	p	NN
cord-006229-7yoilsho	2540	3	-	-	HYPH
cord-006229-7yoilsho	2540	4	Ser2	Ser2	NNP
cord-006229-7yoilsho	2540	5	)	)	-RRB-
cord-006229-7yoilsho	2540	6	of	of	IN
cord-006229-7yoilsho	2540	7	the	the	DT
cord-006229-7yoilsho	2540	8	carboxyterminal	carboxyterminal	JJ
cord-006229-7yoilsho	2540	9	domain	domain	NN
cord-006229-7yoilsho	2540	10	of	of	IN
cord-006229-7yoilsho	2540	11	Pol	Pol	NNP
cord-006229-7yoilsho	2540	12	II	II	NNP
cord-006229-7yoilsho	2540	13	.	.	.
cord-006229-7yoilsho	2541	1	Thus	thus	RB
cord-006229-7yoilsho	2541	2	,	,	,
cord-006229-7yoilsho	2541	3	the	the	DT
cord-006229-7yoilsho	2541	4	aim	aim	NN
cord-006229-7yoilsho	2541	5	of	of	IN
cord-006229-7yoilsho	2541	6	the	the	DT
cord-006229-7yoilsho	2541	7	present	present	JJ
cord-006229-7yoilsho	2541	8	study	study	NN
cord-006229-7yoilsho	2541	9	was	be	VBD
cord-006229-7yoilsho	2541	10	to	to	TO
cord-006229-7yoilsho	2541	11	identify	identify	VB
cord-006229-7yoilsho	2541	12	cardiomyocyte	cardiomyocyte	NN
cord-006229-7yoilsho	2541	13	-	-	HYPH
cord-006229-7yoilsho	2541	14	specific	specific	JJ
cord-006229-7yoilsho	2541	15	genomewide	genomewide	NN
cord-006229-7yoilsho	2541	16	Pol	Pol	NNP
cord-006229-7yoilsho	2541	17	II	II	NNP
cord-006229-7yoilsho	2541	18	and	and	CC
cord-006229-7yoilsho	2541	19	P	P	NNP
cord-006229-7yoilsho	2541	20	-	-	HYPH
cord-006229-7yoilsho	2541	21	Ser2-Pol	Ser2-Pol	NNP
cord-006229-7yoilsho	2541	22	II	ii	CD
cord-006229-7yoilsho	2541	23	enrichments	enrichment	NNS
cord-006229-7yoilsho	2541	24	to	to	TO
cord-006229-7yoilsho	2541	25	get	get	VB
cord-006229-7yoilsho	2541	26	insight	insight	NN
cord-006229-7yoilsho	2541	27	into	into	IN
cord-006229-7yoilsho	2541	28	Pol	Pol	NNP
cord-006229-7yoilsho	2541	29	II	II	NNP
cord-006229-7yoilsho	2541	30	activity	activity	NN
cord-006229-7yoilsho	2541	31	and	and	CC
cord-006229-7yoilsho	2541	32	recruitment	recruitment	NN
cord-006229-7yoilsho	2541	33	in	in	IN
cord-006229-7yoilsho	2541	34	development	development	NN
cord-006229-7yoilsho	2541	35	and	and	CC
cord-006229-7yoilsho	2541	36	disease	disease	NN
cord-006229-7yoilsho	2541	37	.	.	.
cord-006229-7yoilsho	2542	1	Methods	method	NNS
cord-006229-7yoilsho	2542	2	and	and	CC
cord-006229-7yoilsho	2542	3	results	result	NNS
cord-006229-7yoilsho	2542	4	:	:	:
cord-006229-7yoilsho	2542	5	To	to	TO
cord-006229-7yoilsho	2542	6	get	get	VB
cord-006229-7yoilsho	2542	7	insight	insight	NN
cord-006229-7yoilsho	2542	8	into	into	IN
cord-006229-7yoilsho	2542	9	RNA	RNA	NNP
cord-006229-7yoilsho	2542	10	polymerase	polymerase	NN
cord-006229-7yoilsho	2542	11	II	II	NNP
cord-006229-7yoilsho	2542	12	dynamics	dynamic	NNS
cord-006229-7yoilsho	2542	13	,	,	,
cord-006229-7yoilsho	2542	14	genome	genome	NN
cord-006229-7yoilsho	2542	15	-	-	HYPH
cord-006229-7yoilsho	2542	16	wide	wide	JJ
cord-006229-7yoilsho	2542	17	maps	map	NNS
cord-006229-7yoilsho	2542	18	of	of	IN
cord-006229-7yoilsho	2542	19	RNA	RNA	NNP
cord-006229-7yoilsho	2542	20	polymerase	polymerase	NN
cord-006229-7yoilsho	2542	21	II	II	NNP
cord-006229-7yoilsho	2542	22	occupancy	occupancy	NN
cord-006229-7yoilsho	2542	23	were	be	VBD
cord-006229-7yoilsho	2542	24	generated	generate	VBN
cord-006229-7yoilsho	2542	25	by	by	IN
cord-006229-7yoilsho	2542	26	chromatinimmunoprecipitation	chromatinimmunoprecipitation	NN
cord-006229-7yoilsho	2542	27	in	in	IN
cord-006229-7yoilsho	2542	28	cardiomyocyte	cardiomyocyte	NNP
cord-006229-7yoilsho	2542	29	nuclei	nucleus	NNS
cord-006229-7yoilsho	2542	30	purified	purify	VBN
cord-006229-7yoilsho	2542	31	from	from	IN
cord-006229-7yoilsho	2542	32	normal	normal	JJ
cord-006229-7yoilsho	2542	33	neonatal	neonatal	JJ
cord-006229-7yoilsho	2542	34	and	and	CC
cord-006229-7yoilsho	2542	35	adult	adult	NN
cord-006229-7yoilsho	2542	36	mouse	mouse	NN
cord-006229-7yoilsho	2542	37	hearts	heart	NNS
cord-006229-7yoilsho	2542	38	.	.	.
cord-006229-7yoilsho	2543	1	In	in	IN
cord-006229-7yoilsho	2543	2	addition	addition	NN
cord-006229-7yoilsho	2543	3	,	,	,
cord-006229-7yoilsho	2543	4	cardiomyocyte	cardiomyocyte	NN
cord-006229-7yoilsho	2543	5	nuclei	nucleus	NNS
cord-006229-7yoilsho	2543	6	were	be	VBD
cord-006229-7yoilsho	2543	7	obtained	obtain	VBN
cord-006229-7yoilsho	2543	8	from	from	IN
cord-006229-7yoilsho	2543	9	adult	adult	NN
cord-006229-7yoilsho	2543	10	hearts	heart	NNS
cord-006229-7yoilsho	2543	11	after	after	IN
cord-006229-7yoilsho	2543	12	4	4	CD
cord-006229-7yoilsho	2543	13	weeks	week	NNS
cord-006229-7yoilsho	2543	14	of	of	IN
cord-006229-7yoilsho	2543	15	pressure	pressure	NN
cord-006229-7yoilsho	2543	16	overload	overload	NN
cord-006229-7yoilsho	2543	17	induced	induce	VBN
cord-006229-7yoilsho	2543	18	by	by	IN
cord-006229-7yoilsho	2543	19	transverse	transverse	JJ
cord-006229-7yoilsho	2543	20	aortic	aortic	JJ
cord-006229-7yoilsho	2543	21	constriction	constriction	NN
cord-006229-7yoilsho	2543	22	(	(	-LRB-
cord-006229-7yoilsho	2543	23	TAC	TAC	NNP
cord-006229-7yoilsho	2543	24	)	)	-RRB-
cord-006229-7yoilsho	2543	25	.	.	.
cord-006229-7yoilsho	2544	1	Cardiomyocyte	Cardiomyocyte	NNP
cord-006229-7yoilsho	2544	2	nuclei	nucleus	NNS
cord-006229-7yoilsho	2544	3	were	be	VBD
cord-006229-7yoilsho	2544	4	isolated	isolate	VBN
cord-006229-7yoilsho	2544	5	by	by	IN
cord-006229-7yoilsho	2544	6	magnetic	magnetic	JJ
cord-006229-7yoilsho	2544	7	beads	bead	NNS
cord-006229-7yoilsho	2544	8	with	with	IN
cord-006229-7yoilsho	2544	9	an	an	DT
cord-006229-7yoilsho	2544	10	anti	anti	JJ
cord-006229-7yoilsho	2544	11	-	-	JJ
cord-006229-7yoilsho	2544	12	PCM1	pcm1	JJ
cord-006229-7yoilsho	2544	13	antibody	antibody	NN
cord-006229-7yoilsho	2544	14	.	.	.
cord-006229-7yoilsho	2545	1	Nuclei	nucleus	NNS
cord-006229-7yoilsho	2545	2	were	be	VBD
cord-006229-7yoilsho	2545	3	used	use	VBN
cord-006229-7yoilsho	2545	4	for	for	IN
cord-006229-7yoilsho	2545	5	Pol	Pol	NNP
cord-006229-7yoilsho	2545	6	II	II	NNP
cord-006229-7yoilsho	2545	7	chromatin	chromatin	NN
cord-006229-7yoilsho	2545	8	-	-	HYPH
cord-006229-7yoilsho	2545	9	immunoprecipitation	immunoprecipitation	NN
cord-006229-7yoilsho	2545	10	followed	follow	VBN
cord-006229-7yoilsho	2545	11	by	by	IN
cord-006229-7yoilsho	2545	12	deep	deep	JJ
cord-006229-7yoilsho	2545	13	sequencing	sequencing	NN
cord-006229-7yoilsho	2545	14	(	(	-LRB-
cord-006229-7yoilsho	2545	15	ChIP	chip	NN
cord-006229-7yoilsho	2545	16	-	-	HYPH
cord-006229-7yoilsho	2545	17	seq	seq	NNP
cord-006229-7yoilsho	2545	18	)	)	-RRB-
cord-006229-7yoilsho	2545	19	.	.	.
cord-006229-7yoilsho	2546	1	To	to	TO
cord-006229-7yoilsho	2546	2	test	test	VB
cord-006229-7yoilsho	2546	3	if	if	IN
cord-006229-7yoilsho	2546	4	Pol	Pol	NNP
cord-006229-7yoilsho	2546	5	II	II	NNP
cord-006229-7yoilsho	2546	6	marks	mark	NNS
cord-006229-7yoilsho	2546	7	correlate	correlate	VBP
cord-006229-7yoilsho	2546	8	with	with	IN
cord-006229-7yoilsho	2546	9	nuclear	nuclear	JJ
cord-006229-7yoilsho	2546	10	mRNA	mRNA	NNP
cord-006229-7yoilsho	2546	11	expression	expression	NN
cord-006229-7yoilsho	2546	12	in	in	IN
cord-006229-7yoilsho	2546	13	cardiomyocyte	cardiomyocyte	NNP
cord-006229-7yoilsho	2546	14	nuclei	nucleus	NNS
cord-006229-7yoilsho	2546	15	all	all	DT
cord-006229-7yoilsho	2546	16	coding	code	VBG
cord-006229-7yoilsho	2546	17	genes	gene	NNS
cord-006229-7yoilsho	2546	18	were	be	VBD
cord-006229-7yoilsho	2546	19	ranked	rank	VBN
cord-006229-7yoilsho	2546	20	according	accord	VBG
cord-006229-7yoilsho	2546	21	to	to	IN
cord-006229-7yoilsho	2546	22	their	-PRON-	PRP$
cord-006229-7yoilsho	2546	23	expression	expression	NN
cord-006229-7yoilsho	2546	24	level	level	NN
cord-006229-7yoilsho	2546	25	.	.	.
cord-006229-7yoilsho	2547	1	Genes	gene	NNS
cord-006229-7yoilsho	2547	2	expressed	express	VBN
cord-006229-7yoilsho	2547	3	in	in	IN
cord-006229-7yoilsho	2547	4	cardiomyocyte	cardiomyocyte	NNP
cord-006229-7yoilsho	2547	5	nuclei	nucleus	NNS
cord-006229-7yoilsho	2547	6	(	(	-LRB-
cord-006229-7yoilsho	2547	7	>	>	NFP
cord-006229-7yoilsho	2547	8	0.062	0.062	CD
cord-006229-7yoilsho	2547	9	FPKM	fpkm	NN
cord-006229-7yoilsho	2547	10	,	,	,
cord-006229-7yoilsho	2547	11	gene	gene	NN
cord-006229-7yoilsho	2547	12	expression	expression	NN
cord-006229-7yoilsho	2547	13	rank	rank	NN
cord-006229-7yoilsho	2547	14	<	<	XX
cord-006229-7yoilsho	2547	15	12,653	12,653	CD
cord-006229-7yoilsho	2547	16	)	)	-RRB-
cord-006229-7yoilsho	2547	17	showed	show	VBD
cord-006229-7yoilsho	2547	18	high	high	JJ
cord-006229-7yoilsho	2547	19	Pol	Pol	NNP
cord-006229-7yoilsho	2547	20	II	II	NNP
cord-006229-7yoilsho	2547	21	enrichment	enrichment	NN
cord-006229-7yoilsho	2547	22	at	at	IN
cord-006229-7yoilsho	2547	23	promoters	promoter	NNS
cord-006229-7yoilsho	2547	24	as	as	RB
cord-006229-7yoilsho	2547	25	well	well	RB
cord-006229-7yoilsho	2547	26	as	as	IN
cord-006229-7yoilsho	2547	27	in	in	IN
cord-006229-7yoilsho	2547	28	genomic	genomic	JJ
cord-006229-7yoilsho	2547	29	regions	region	NNS
cord-006229-7yoilsho	2547	30	.	.	.
cord-006229-7yoilsho	2548	1	Many	many	JJ
cord-006229-7yoilsho	2548	2	of	of	IN
cord-006229-7yoilsho	2548	3	the	the	DT
cord-006229-7yoilsho	2548	4	gene	gene	NN
cord-006229-7yoilsho	2548	5	promoters	promoter	NNS
cord-006229-7yoilsho	2548	6	showed	show	VBD
cord-006229-7yoilsho	2548	7	high	high	JJ
cord-006229-7yoilsho	2548	8	levels	level	NNS
cord-006229-7yoilsho	2548	9	of	of	IN
cord-006229-7yoilsho	2548	10	Pol	Pol	NNP
cord-006229-7yoilsho	2548	11	II	II	NNP
cord-006229-7yoilsho	2548	12	accumulation	accumulation	NN
cord-006229-7yoilsho	2548	13	at	at	IN
cord-006229-7yoilsho	2548	14	the	the	DT
cord-006229-7yoilsho	2548	15	transcription	transcription	NN
cord-006229-7yoilsho	2548	16	start	start	NN
cord-006229-7yoilsho	2548	17	site	site	NN
cord-006229-7yoilsho	2548	18	,	,	,
cord-006229-7yoilsho	2548	19	as	as	IN
cord-006229-7yoilsho	2548	20	compared	compare	VBN
cord-006229-7yoilsho	2548	21	to	to	IN
cord-006229-7yoilsho	2548	22	genic	genic	JJ
cord-006229-7yoilsho	2548	23	regions	region	NNS
cord-006229-7yoilsho	2548	24	,	,	,
cord-006229-7yoilsho	2548	25	which	which	WDT
cord-006229-7yoilsho	2548	26	have	have	VBP
cord-006229-7yoilsho	2548	27	been	be	VBN
cord-006229-7yoilsho	2548	28	associated	associate	VBN
cord-006229-7yoilsho	2548	29	with	with	IN
cord-006229-7yoilsho	2548	30	Pol	Pol	NNP
cord-006229-7yoilsho	2548	31	II	II	NNP
cord-006229-7yoilsho	2548	32	pausing	pause	VBG
cord-006229-7yoilsho	2548	33	.	.	.
cord-006229-7yoilsho	2549	1	In	in	IN
cord-006229-7yoilsho	2549	2	contrast	contrast	NN
cord-006229-7yoilsho	2549	3	,	,	,
cord-006229-7yoilsho	2549	4	P	p	NN
cord-006229-7yoilsho	2549	5	-	-	HYPH
cord-006229-7yoilsho	2549	6	Ser2-Pol	Ser2-Pol	NNP
cord-006229-7yoilsho	2549	7	II	II	NNP
cord-006229-7yoilsho	2549	8	showed	show	VBD
cord-006229-7yoilsho	2549	9	enrichment	enrichment	NN
cord-006229-7yoilsho	2549	10	downstream	downstream	NN
cord-006229-7yoilsho	2549	11	of	of	IN
cord-006229-7yoilsho	2549	12	the	the	DT
cord-006229-7yoilsho	2549	13	transcription	transcription	NN
cord-006229-7yoilsho	2549	14	start	start	NN
cord-006229-7yoilsho	2549	15	site	site	NN
cord-006229-7yoilsho	2549	16	.	.	.
cord-006229-7yoilsho	2550	1	The	the	DT
cord-006229-7yoilsho	2550	2	genomic	genomic	JJ
cord-006229-7yoilsho	2550	3	region	region	NN
cord-006229-7yoilsho	2550	4	of	of	IN
cord-006229-7yoilsho	2550	5	troponin	troponin	NN
cord-006229-7yoilsho	2550	6	I	-PRON-	PRP
cord-006229-7yoilsho	2550	7	type	type	NN
cord-006229-7yoilsho	2550	8	1	1	CD
cord-006229-7yoilsho	2550	9	(	(	-LRB-
cord-006229-7yoilsho	2550	10	Tnni1	Tnni1	NNP
cord-006229-7yoilsho	2550	11	)	)	-RRB-
cord-006229-7yoilsho	2550	12	which	which	WDT
cord-006229-7yoilsho	2550	13	is	be	VBZ
cord-006229-7yoilsho	2550	14	expressed	express	VBN
cord-006229-7yoilsho	2550	15	in	in	IN
cord-006229-7yoilsho	2550	16	cardiac	cardiac	JJ
cord-006229-7yoilsho	2550	17	muscle	muscle	NN
cord-006229-7yoilsho	2550	18	only	only	RB
cord-006229-7yoilsho	2550	19	during	during	IN
cord-006229-7yoilsho	2550	20	development	development	NN
cord-006229-7yoilsho	2550	21	but	but	CC
cord-006229-7yoilsho	2550	22	not	not	RB
cord-006229-7yoilsho	2550	23	in	in	IN
cord-006229-7yoilsho	2550	24	adult	adult	NN
cord-006229-7yoilsho	2550	25	cardiomyocytes	cardiomyocyte	NNS
cord-006229-7yoilsho	2550	26	,	,	,
cord-006229-7yoilsho	2550	27	was	be	VBD
cord-006229-7yoilsho	2550	28	enriched	enrich	VBN
cord-006229-7yoilsho	2550	29	for	for	IN
cord-006229-7yoilsho	2550	30	Pol	Pol	NNP
cord-006229-7yoilsho	2550	31	II	II	NNP
cord-006229-7yoilsho	2550	32	in	in	IN
cord-006229-7yoilsho	2550	33	neonatal	neonatal	JJ
cord-006229-7yoilsho	2550	34	cardiomyocytes	cardiomyocyte	NNS
cord-006229-7yoilsho	2550	35	.	.	.
cord-006229-7yoilsho	2551	1	At	at	IN
cord-006229-7yoilsho	2551	2	the	the	DT
cord-006229-7yoilsho	2551	3	Tnni1	Tnni1	NNP
cord-006229-7yoilsho	2551	4	gene	gene	NN
cord-006229-7yoilsho	2551	5	,	,	,
cord-006229-7yoilsho	2551	6	Pol	Pol	NNP
cord-006229-7yoilsho	2551	7	II	II	NNP
cord-006229-7yoilsho	2551	8	was	be	VBD
cord-006229-7yoilsho	2551	9	absent	absent	JJ
cord-006229-7yoilsho	2551	10	in	in	IN
cord-006229-7yoilsho	2551	11	adult	adult	NN
cord-006229-7yoilsho	2551	12	or	or	CC
cord-006229-7yoilsho	2551	13	pressure	pressure	NN
cord-006229-7yoilsho	2551	14	-	-	HYPH
cord-006229-7yoilsho	2551	15	overloaded	overload	VBN
cord-006229-7yoilsho	2551	16	cardiomyocytes	cardiomyocyte	NNS
cord-006229-7yoilsho	2551	17	.	.	.
cord-006229-7yoilsho	2552	1	In	in	IN
cord-006229-7yoilsho	2552	2	contrast	contrast	NN
cord-006229-7yoilsho	2552	3	,	,	,
cord-006229-7yoilsho	2552	4	Pol	Pol	NNP
cord-006229-7yoilsho	2552	5	II	II	NNP
cord-006229-7yoilsho	2552	6	enrichment	enrichment	NN
cord-006229-7yoilsho	2552	7	at	at	IN
cord-006229-7yoilsho	2552	8	the	the	DT
cord-006229-7yoilsho	2552	9	alpha	alpha	NN
cord-006229-7yoilsho	2552	10	actin	actin	NN
cord-006229-7yoilsho	2552	11	1	1	CD
cord-006229-7yoilsho	2553	1	(	(	-LRB-
cord-006229-7yoilsho	2553	2	Acta1	Acta1	NNP
cord-006229-7yoilsho	2553	3	)	)	-RRB-
cord-006229-7yoilsho	2553	4	locus	locus	NN
cord-006229-7yoilsho	2553	5	was	be	VBD
cord-006229-7yoilsho	2553	6	only	only	RB
cord-006229-7yoilsho	2553	7	present	present	JJ
cord-006229-7yoilsho	2553	8	in	in	IN
cord-006229-7yoilsho	2553	9	pressure	pressure	NN
cord-006229-7yoilsho	2553	10	-	-	HYPH
cord-006229-7yoilsho	2553	11	overloaded	overload	VBN
cord-006229-7yoilsho	2553	12	cardiomyocytes	cardiomyocyte	NNS
cord-006229-7yoilsho	2553	13	.	.	.
cord-006229-7yoilsho	2554	1	These	these	DT
cord-006229-7yoilsho	2554	2	data	datum	NNS
cord-006229-7yoilsho	2554	3	are	be	VBP
cord-006229-7yoilsho	2554	4	consistent	consistent	JJ
cord-006229-7yoilsho	2554	5	with	with	IN
cord-006229-7yoilsho	2554	6	cellular	cellular	JJ
cord-006229-7yoilsho	2554	7	RNA	RNA	NNP
cord-006229-7yoilsho	2554	8	-	-	HYPH
cord-006229-7yoilsho	2554	9	seq	seq	NNP
cord-006229-7yoilsho	2554	10	data	datum	NNS
cord-006229-7yoilsho	2554	11	showing	show	VBG
cord-006229-7yoilsho	2554	12	an	an	DT
cord-006229-7yoilsho	2554	13	induction	induction	NN
cord-006229-7yoilsho	2554	14	of	of	IN
cord-006229-7yoilsho	2554	15	Acta1	Acta1	NNP
cord-006229-7yoilsho	2554	16	after	after	IN
cord-006229-7yoilsho	2554	17	TAC	TAC	NNP
cord-006229-7yoilsho	2554	18	.	.	.
cord-006229-7yoilsho	2555	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	2555	2	no	no	DT
cord-006229-7yoilsho	2555	3	Pol	Pol	NNP
cord-006229-7yoilsho	2555	4	II	II	NNP
cord-006229-7yoilsho	2555	5	enrichment	enrichment	NN
cord-006229-7yoilsho	2555	6	could	could	MD
cord-006229-7yoilsho	2555	7	be	be	VB
cord-006229-7yoilsho	2555	8	detected	detect	VBN
cord-006229-7yoilsho	2555	9	in	in	IN
cord-006229-7yoilsho	2555	10	the	the	DT
cord-006229-7yoilsho	2555	11	genomic	genomic	JJ
cord-006229-7yoilsho	2555	12	region	region	NN
cord-006229-7yoilsho	2555	13	of	of	IN
cord-006229-7yoilsho	2555	14	biglycan	biglycan	NNP
cord-006229-7yoilsho	2555	15	(	(	-LRB-
cord-006229-7yoilsho	2555	16	Bgn	Bgn	NNP
cord-006229-7yoilsho	2555	17	)	)	-RRB-
cord-006229-7yoilsho	2555	18	,	,	,
cord-006229-7yoilsho	2555	19	a	a	DT
cord-006229-7yoilsho	2555	20	matrix	matrix	NN
cord-006229-7yoilsho	2555	21	proteoglycan	proteoglycan	NN
cord-006229-7yoilsho	2555	22	that	that	WDT
cord-006229-7yoilsho	2555	23	is	be	VBZ
cord-006229-7yoilsho	2555	24	not	not	RB
cord-006229-7yoilsho	2555	25	expressed	express	VBN
cord-006229-7yoilsho	2555	26	in	in	IN
cord-006229-7yoilsho	2555	27	cardiomyocytes	cardiomyocyte	NNS
cord-006229-7yoilsho	2555	28	.	.	.
cord-006229-7yoilsho	2556	1	This	this	DT
cord-006229-7yoilsho	2556	2	confirms	confirm	VBZ
cord-006229-7yoilsho	2556	3	a	a	DT
cord-006229-7yoilsho	2556	4	high	high	JJ
cord-006229-7yoilsho	2556	5	purity	purity	NN
cord-006229-7yoilsho	2556	6	of	of	IN
cord-006229-7yoilsho	2556	7	cardiomyocyte	cardiomyocyte	NNP
cord-006229-7yoilsho	2556	8	chromatin	chromatin	NN
cord-006229-7yoilsho	2556	9	.	.	.
cord-006229-7yoilsho	2557	1	Conclusions	conclusion	NNS
cord-006229-7yoilsho	2557	2	:	:	:
cord-006229-7yoilsho	2558	1	This	this	DT
cord-006229-7yoilsho	2558	2	study	study	NN
cord-006229-7yoilsho	2558	3	provides	provide	VBZ
cord-006229-7yoilsho	2558	4	,	,	,
cord-006229-7yoilsho	2558	5	for	for	IN
cord-006229-7yoilsho	2558	6	the	the	DT
cord-006229-7yoilsho	2558	7	first	first	JJ
cord-006229-7yoilsho	2558	8	time	time	NN
cord-006229-7yoilsho	2558	9	,	,	,
cord-006229-7yoilsho	2558	10	cardiomyocyte	cardiomyocyte	NN
cord-006229-7yoilsho	2558	11	-	-	HYPH
cord-006229-7yoilsho	2558	12	specific	specific	JJ
cord-006229-7yoilsho	2558	13	landscapes	landscape	NNS
cord-006229-7yoilsho	2558	14	of	of	IN
cord-006229-7yoilsho	2558	15	RNA	RNA	NNP
cord-006229-7yoilsho	2558	16	polymerase	polymerase	NN
cord-006229-7yoilsho	2558	17	II	II	NNP
cord-006229-7yoilsho	2558	18	occupancy	occupancy	NN
cord-006229-7yoilsho	2558	19	in	in	IN
cord-006229-7yoilsho	2558	20	heart	heart	NN
cord-006229-7yoilsho	2558	21	development	development	NN
cord-006229-7yoilsho	2558	22	and	and	CC
cord-006229-7yoilsho	2558	23	disease	disease	NN
cord-006229-7yoilsho	2558	24	.	.	.
cord-006229-7yoilsho	2559	1	Cardiac	cardiac	JJ
cord-006229-7yoilsho	2559	2	myocyte	myocyte	NN
cord-006229-7yoilsho	2559	3	maintenance	maintenance	NN
cord-006229-7yoilsho	2559	4	DNA	dna	NN
cord-006229-7yoilsho	2560	1	methyltransferase	methyltransferase	NNP
cord-006229-7yoilsho	2560	2	1	1	CD
cord-006229-7yoilsho	2560	3	is	be	VBZ
cord-006229-7yoilsho	2560	4	essential	essential	JJ
cord-006229-7yoilsho	2560	5	for	for	IN
cord-006229-7yoilsho	2560	6	embryonic	embryonic	JJ
cord-006229-7yoilsho	2560	7	heart	heart	NN
cord-006229-7yoilsho	2560	8	development	development	NN
cord-006229-7yoilsho	2560	9	but	but	CC
cord-006229-7yoilsho	2560	10	is	be	VBZ
cord-006229-7yoilsho	2560	11	dispensable	dispensable	JJ
cord-006229-7yoilsho	2560	12	for	for	IN
cord-006229-7yoilsho	2560	13	cardiac	cardiac	JJ
cord-006229-7yoilsho	2560	14	function	function	NN
cord-006229-7yoilsho	2560	15	and	and	CC
cord-006229-7yoilsho	2560	16	remodeling	remodeling	NN
cord-006229-7yoilsho	2561	1	postnatally	postnatally	NNP
cord-006229-7yoilsho	2561	2	T.	T.	NNP
cord-006229-7yoilsho	2561	3	Nührenberg	Nührenberg	NNP
cord-006229-7yoilsho	2561	4	Background	Background	NNP
cord-006229-7yoilsho	2561	5	:	:	:
cord-006229-7yoilsho	2562	1	Recent	recent	JJ
cord-006229-7yoilsho	2562	2	studies	study	NNS
cord-006229-7yoilsho	2562	3	have	have	VBP
cord-006229-7yoilsho	2562	4	identified	identify	VBN
cord-006229-7yoilsho	2562	5	dynamic	dynamic	JJ
cord-006229-7yoilsho	2562	6	changes	change	NNS
cord-006229-7yoilsho	2562	7	in	in	IN
cord-006229-7yoilsho	2562	8	DNA	dna	NN
cord-006229-7yoilsho	2562	9	methylation	methylation	NN
cord-006229-7yoilsho	2562	10	in	in	IN
cord-006229-7yoilsho	2562	11	cardiac	cardiac	JJ
cord-006229-7yoilsho	2562	12	myocytes	myocyte	NNS
cord-006229-7yoilsho	2562	13	during	during	IN
cord-006229-7yoilsho	2562	14	development	development	NN
cord-006229-7yoilsho	2562	15	,	,	,
cord-006229-7yoilsho	2562	16	postnatal	postnatal	JJ
cord-006229-7yoilsho	2562	17	maturation	maturation	NN
cord-006229-7yoilsho	2562	18	and	and	CC
cord-006229-7yoilsho	2562	19	in	in	IN
cord-006229-7yoilsho	2562	20	disease	disease	NN
cord-006229-7yoilsho	2562	21	.	.	.
cord-006229-7yoilsho	2563	1	However	however	RB
cord-006229-7yoilsho	2563	2	,	,	,
cord-006229-7yoilsho	2563	3	the	the	DT
cord-006229-7yoilsho	2563	4	enzymes	enzyme	NNS
cord-006229-7yoilsho	2563	5	involved	involve	VBN
cord-006229-7yoilsho	2563	6	in	in	IN
cord-006229-7yoilsho	2563	7	shaping	shape	VBG
cord-006229-7yoilsho	2563	8	the	the	DT
cord-006229-7yoilsho	2563	9	cardiac	cardiac	NN
cord-006229-7yoilsho	2563	10	myocyte	myocyte	NNP
cord-006229-7yoilsho	2563	11	DNA	DNA	NNP
cord-006229-7yoilsho	2563	12	methylome	methylome	NNP
cord-006229-7yoilsho	2563	13	are	be	VBP
cord-006229-7yoilsho	2563	14	only	only	RB
cord-006229-7yoilsho	2563	15	partially	partially	RB
cord-006229-7yoilsho	2563	16	known	know	VBN
cord-006229-7yoilsho	2563	17	.	.	.
cord-006229-7yoilsho	2564	1	Here	here	RB
cord-006229-7yoilsho	2564	2	,	,	,
cord-006229-7yoilsho	2564	3	we	-PRON-	PRP
cord-006229-7yoilsho	2564	4	explored	explore	VBD
cord-006229-7yoilsho	2564	5	the	the	DT
cord-006229-7yoilsho	2564	6	role	role	NN
cord-006229-7yoilsho	2564	7	of	of	IN
cord-006229-7yoilsho	2564	8	maintenance	maintenance	NN
cord-006229-7yoilsho	2564	9	DNA	dna	NN
cord-006229-7yoilsho	2564	10	methyltransferase	methyltransferase	NN
cord-006229-7yoilsho	2564	11	Dnmt1	Dnmt1	VBN
cord-006229-7yoilsho	2564	12	in	in	IN
cord-006229-7yoilsho	2564	13	cardiac	cardiac	JJ
cord-006229-7yoilsho	2564	14	development	development	NN
cord-006229-7yoilsho	2564	15	and	and	CC
cord-006229-7yoilsho	2564	16	in	in	IN
cord-006229-7yoilsho	2564	17	remodeling	remodeling	NN
cord-006229-7yoilsho	2564	18	after	after	IN
cord-006229-7yoilsho	2564	19	chronic	chronic	JJ
cord-006229-7yoilsho	2564	20	left	leave	VBD
cord-006229-7yoilsho	2564	21	ventricular	ventricular	JJ
cord-006229-7yoilsho	2564	22	pressure	pressure	NN
cord-006229-7yoilsho	2564	23	overload	overload	NN
cord-006229-7yoilsho	2564	24	.	.	.
cord-006229-7yoilsho	2565	1	Methods	method	NNS
cord-006229-7yoilsho	2565	2	:	:	:
cord-006229-7yoilsho	2565	3	In	in	IN
cord-006229-7yoilsho	2565	4	mice	mouse	NNS
cord-006229-7yoilsho	2565	5	,	,	,
cord-006229-7yoilsho	2565	6	deletion	deletion	NN
cord-006229-7yoilsho	2565	7	of	of	IN
cord-006229-7yoilsho	2565	8	the	the	DT
cord-006229-7yoilsho	2565	9	Dnmt1	Dnmt1	NNP
cord-006229-7yoilsho	2565	10	gene	gene	NN
cord-006229-7yoilsho	2565	11	was	be	VBD
cord-006229-7yoilsho	2565	12	accomplished	accomplish	VBN
cord-006229-7yoilsho	2565	13	by	by	IN
cord-006229-7yoilsho	2565	14	use	use	NN
cord-006229-7yoilsho	2565	15	of	of	IN
cord-006229-7yoilsho	2565	16	two	two	CD
cord-006229-7yoilsho	2565	17	different	different	JJ
cord-006229-7yoilsho	2565	18	Cre	Cre	NNP
cord-006229-7yoilsho	2565	19	recombinases	recombinase	NNS
cord-006229-7yoilsho	2565	20	.	.	.
cord-006229-7yoilsho	2566	1	Crosses	crosse	NNS
cord-006229-7yoilsho	2566	2	of	of	IN
cord-006229-7yoilsho	2566	3	homozygous	homozygous	JJ
cord-006229-7yoilsho	2566	4	Dnmt1	Dnmt1	NNP
cord-006229-7yoilsho	2566	5	fl	fl	NNP
cord-006229-7yoilsho	2566	6	/	/	SYM
cord-006229-7yoilsho	2566	7	fl	fl	NNP
cord-006229-7yoilsho	2566	8	mice	mouse	NNS
cord-006229-7yoilsho	2566	9	with	with	IN
cord-006229-7yoilsho	2566	10	heterozygous	heterozygous	JJ
cord-006229-7yoilsho	2566	11	Dnmt1	Dnmt1	NNP
cord-006229-7yoilsho	2566	12	fl/+	fl/+	IN
cord-006229-7yoilsho	2566	13	mice	mouse	NNS
cord-006229-7yoilsho	2566	14	expressing	express	VBG
cord-006229-7yoilsho	2566	15	a	a	DT
cord-006229-7yoilsho	2566	16	Cre	Cre	NNP
cord-006229-7yoilsho	2566	17	recombinase	recombinase	NN
cord-006229-7yoilsho	2566	18	under	under	IN
cord-006229-7yoilsho	2566	19	control	control	NN
cord-006229-7yoilsho	2566	20	of	of	IN
cord-006229-7yoilsho	2566	21	the	the	DT
cord-006229-7yoilsho	2566	22	atrial	atrial	JJ
cord-006229-7yoilsho	2566	23	myosin	myosin	NN
cord-006229-7yoilsho	2566	24	light	light	JJ
cord-006229-7yoilsho	2566	25	chain	chain	NN
cord-006229-7yoilsho	2566	26	gene	gene	NN
cord-006229-7yoilsho	2566	27	promoter	promoter	NN
cord-006229-7yoilsho	2566	28	(	(	-LRB-
cord-006229-7yoilsho	2566	29	Myl7-Cre	Myl7-Cre	NNP
cord-006229-7yoilsho	2566	30	)	)	-RRB-
cord-006229-7yoilsho	2566	31	resulted	result	VBD
cord-006229-7yoilsho	2566	32	in	in	IN
cord-006229-7yoilsho	2566	33	embryonic	embryonic	JJ
cord-006229-7yoilsho	2566	34	deletion	deletion	NN
cord-006229-7yoilsho	2566	35	of	of	IN
cord-006229-7yoilsho	2566	36	Dnmt1	Dnmt1	NNP
cord-006229-7yoilsho	2566	37	(	(	-LRB-
cord-006229-7yoilsho	2566	38	KO	KO	NNP
cord-006229-7yoilsho	2566	39	)	)	-RRB-
cord-006229-7yoilsho	2566	40	.	.	.
cord-006229-7yoilsho	2567	1	Embryos	embryo	NNS
cord-006229-7yoilsho	2567	2	without	without	IN
cord-006229-7yoilsho	2567	3	Myl7-Cre	Myl7-Cre	NNP
cord-006229-7yoilsho	2567	4	served	serve	VBD
cord-006229-7yoilsho	2567	5	as	as	IN
cord-006229-7yoilsho	2567	6	controls	control	NNS
cord-006229-7yoilsho	2567	7	(	(	-LRB-
cord-006229-7yoilsho	2567	8	CTL	CTL	NNP
cord-006229-7yoilsho	2567	9	)	)	-RRB-
cord-006229-7yoilsho	2567	10	.	.	.
cord-006229-7yoilsho	2568	1	Embryos	embryo	NNS
cord-006229-7yoilsho	2568	2	were	be	VBD
cord-006229-7yoilsho	2568	3	dissected	dissect	VBN
cord-006229-7yoilsho	2568	4	and	and	CC
cord-006229-7yoilsho	2568	5	genotyped	genotype	VBN
cord-006229-7yoilsho	2568	6	at	at	IN
cord-006229-7yoilsho	2568	7	E11.5	E11.5	NNS
cord-006229-7yoilsho	2568	8	,	,	,
cord-006229-7yoilsho	2568	9	E12.5	E12.5	NNP
cord-006229-7yoilsho	2568	10	,	,	,
cord-006229-7yoilsho	2568	11	E13.5	E13.5	NNP
cord-006229-7yoilsho	2568	12	and	and	CC
cord-006229-7yoilsho	2568	13	E14.5	E14.5	NNP
cord-006229-7yoilsho	2568	14	.	.	.
cord-006229-7yoilsho	2569	1	RNA	RNA	NNP
cord-006229-7yoilsho	2569	2	-	-	HYPH
cord-006229-7yoilsho	2569	3	Seq	Seq	NNP
cord-006229-7yoilsho	2569	4	and	and	CC
cord-006229-7yoilsho	2569	5	pyrosequencing	pyrosequencing	NN
cord-006229-7yoilsho	2569	6	of	of	IN
cord-006229-7yoilsho	2569	7	genomic	genomic	JJ
cord-006229-7yoilsho	2569	8	DNA	dna	NN
cord-006229-7yoilsho	2569	9	was	be	VBD
cord-006229-7yoilsho	2569	10	performed	perform	VBN
cord-006229-7yoilsho	2569	11	on	on	IN
cord-006229-7yoilsho	2569	12	E11.5	e11.5	IN
cord-006229-7yoilsho	2569	13	hearts	heart	NNS
cord-006229-7yoilsho	2569	14	,	,	,
cord-006229-7yoilsho	2569	15	histology	histology	NN
cord-006229-7yoilsho	2569	16	on	on	IN
cord-006229-7yoilsho	2569	17	E12.5	E12.5	NNP
cord-006229-7yoilsho	2569	18	hearts	heart	NNS
cord-006229-7yoilsho	2569	19	and	and	CC
cord-006229-7yoilsho	2569	20	electron	electron	NN
cord-006229-7yoilsho	2569	21	microscopic	microscopic	JJ
cord-006229-7yoilsho	2569	22	imaging	imaging	NN
cord-006229-7yoilsho	2569	23	on	on	IN
cord-006229-7yoilsho	2569	24	E13.5	E13.5	NNP
cord-006229-7yoilsho	2569	25	hearts	heart	NNS
cord-006229-7yoilsho	2569	26	.	.	.
cord-006229-7yoilsho	2570	1	For	for	IN
cord-006229-7yoilsho	2570	2	deletion	deletion	NN
cord-006229-7yoilsho	2570	3	of	of	IN
cord-006229-7yoilsho	2570	4	Dnmt1	Dnmt1	NNP
cord-006229-7yoilsho	2570	5	in	in	IN
cord-006229-7yoilsho	2570	6	adult	adult	NN
cord-006229-7yoilsho	2570	7	mice	mouse	NNS
cord-006229-7yoilsho	2570	8	,	,	,
cord-006229-7yoilsho	2570	9	homozygous	homozygous	JJ
cord-006229-7yoilsho	2570	10	Dnmt1	Dnmt1	NNP
cord-006229-7yoilsho	2570	11	fl	fl	NNP
cord-006229-7yoilsho	2570	12	/	/	SYM
cord-006229-7yoilsho	2570	13	fl	fl	NNP
cord-006229-7yoilsho	2570	14	mice	mouse	NNS
cord-006229-7yoilsho	2570	15	expressing	express	VBG
cord-006229-7yoilsho	2570	16	an	an	DT
cord-006229-7yoilsho	2570	17	inducible	inducible	JJ
cord-006229-7yoilsho	2570	18	Cre	Cre	NNP
cord-006229-7yoilsho	2570	19	recombinase	recombinase	NN
cord-006229-7yoilsho	2570	20	(	(	-LRB-
cord-006229-7yoilsho	2570	21	Myh6-MCM	Myh6-MCM	NNP
cord-006229-7yoilsho	2570	22	)	)	-RRB-
cord-006229-7yoilsho	2570	23	were	be	VBD
cord-006229-7yoilsho	2570	24	given	give	VBN
cord-006229-7yoilsho	2570	25	tamoxifen	tamoxifen	NNP
cord-006229-7yoilsho	2570	26	i.p	i.p	NNP
cord-006229-7yoilsho	2570	27	.	.	NNP
cord-006229-7yoilsho	2570	28	over	over	IN
cord-006229-7yoilsho	2570	29	4	4	CD
cord-006229-7yoilsho	2570	30	days	day	NNS
cord-006229-7yoilsho	2570	31	.	.	.
cord-006229-7yoilsho	2571	1	Homozygous	Homozygous	NNP
cord-006229-7yoilsho	2571	2	Dnmt1	Dnmt1	NNP
cord-006229-7yoilsho	2572	1	fl	fl	NNP
cord-006229-7yoilsho	2572	2	/	/	SYM
cord-006229-7yoilsho	2572	3	fl	fl	NNP
cord-006229-7yoilsho	2572	4	mice	mouse	NNS
cord-006229-7yoilsho	2572	5	not	not	RB
cord-006229-7yoilsho	2572	6	carrying	carry	VBG
cord-006229-7yoilsho	2572	7	Myh6-MCM	Myh6-MCM	NNS
cord-006229-7yoilsho	2572	8	as	as	RB
cord-006229-7yoilsho	2572	9	well	well	RB
cord-006229-7yoilsho	2572	10	as	as	IN
cord-006229-7yoilsho	2572	11	Myh6-MCM	Myh6-MCM	NNS
cord-006229-7yoilsho	2572	12	carrying	carry	VBG
cord-006229-7yoilsho	2572	13	mice	mouse	NNS
cord-006229-7yoilsho	2572	14	without	without	IN
cord-006229-7yoilsho	2572	15	Dnmt1	Dnmt1	NNP
cord-006229-7yoilsho	2572	16	fl	fl	NNP
cord-006229-7yoilsho	2572	17	alleles	allele	NNS
cord-006229-7yoilsho	2572	18	were	be	VBD
cord-006229-7yoilsho	2572	19	also	also	RB
cord-006229-7yoilsho	2572	20	injected	inject	VBN
cord-006229-7yoilsho	2572	21	with	with	IN
cord-006229-7yoilsho	2572	22	tamoxifen	tamoxifen	NN
cord-006229-7yoilsho	2572	23	and	and	CC
cord-006229-7yoilsho	2572	24	served	serve	VBD
cord-006229-7yoilsho	2572	25	as	as	IN
cord-006229-7yoilsho	2572	26	controls	control	NNS
cord-006229-7yoilsho	2572	27	.	.	.
cord-006229-7yoilsho	2573	1	Cardiac	cardiac	JJ
cord-006229-7yoilsho	2573	2	phenotyping	phenotyping	NN
cord-006229-7yoilsho	2573	3	including	include	VBG
cord-006229-7yoilsho	2573	4	histology	histology	NN
cord-006229-7yoilsho	2573	5	,	,	,
cord-006229-7yoilsho	2573	6	echocardiography	echocardiography	NN
cord-006229-7yoilsho	2573	7	and	and	CC
cord-006229-7yoilsho	2573	8	qPCR	qPCR	NNP
cord-006229-7yoilsho	2573	9	was	be	VBD
cord-006229-7yoilsho	2573	10	carried	carry	VBN
cord-006229-7yoilsho	2573	11	out	out	RP
cord-006229-7yoilsho	2573	12	without	without	IN
cord-006229-7yoilsho	2573	13	(	(	-LRB-
cord-006229-7yoilsho	2573	14	sham	sham	NN
cord-006229-7yoilsho	2573	15	)	)	-RRB-
cord-006229-7yoilsho	2573	16	or	or	CC
cord-006229-7yoilsho	2573	17	with	with	IN
cord-006229-7yoilsho	2573	18	left	left	JJ
cord-006229-7yoilsho	2573	19	ventricular	ventricular	JJ
cord-006229-7yoilsho	2573	20	pressure	pressure	NN
cord-006229-7yoilsho	2573	21	overload	overload	NN
cord-006229-7yoilsho	2573	22	induced	induce	VBN
cord-006229-7yoilsho	2573	23	by	by	IN
cord-006229-7yoilsho	2573	24	transverse	transverse	JJ
cord-006229-7yoilsho	2573	25	aortic	aortic	JJ
cord-006229-7yoilsho	2573	26	constriction	constriction	NN
cord-006229-7yoilsho	2573	27	(	(	-LRB-
cord-006229-7yoilsho	2573	28	TAC	TAC	NNP
cord-006229-7yoilsho	2573	29	)	)	-RRB-
cord-006229-7yoilsho	2573	30	.	.	.
cord-006229-7yoilsho	2574	1	Results	result	NNS
cord-006229-7yoilsho	2574	2	:	:	:
cord-006229-7yoilsho	2575	1	Myl7-Cre	Myl7-Cre	NNP
cord-006229-7yoilsho	2575	2	mediated	mediate	VBN
cord-006229-7yoilsho	2575	3	loss	loss	NN
cord-006229-7yoilsho	2575	4	of	of	IN
cord-006229-7yoilsho	2575	5	Dnmt1	Dnmt1	NNP
cord-006229-7yoilsho	2575	6	resulted	result	VBD
cord-006229-7yoilsho	2575	7	in	in	IN
cord-006229-7yoilsho	2575	8	progressive	progressive	JJ
cord-006229-7yoilsho	2575	9	embryonic	embryonic	JJ
cord-006229-7yoilsho	2575	10	lethality	lethality	NN
cord-006229-7yoilsho	2575	11	with	with	IN
cord-006229-7yoilsho	2575	12	absence	absence	NN
cord-006229-7yoilsho	2575	13	of	of	IN
cord-006229-7yoilsho	2575	14	living	live	VBG
cord-006229-7yoilsho	2575	15	KO	KO	NNP
cord-006229-7yoilsho	2575	16	embryos	embryo	NNS
cord-006229-7yoilsho	2575	17	after	after	IN
cord-006229-7yoilsho	2575	18	E14.5	E14.5	NNP
cord-006229-7yoilsho	2575	19	.	.	.
cord-006229-7yoilsho	2576	1	KO	KO	NNP
cord-006229-7yoilsho	2576	2	embryos	embryo	NNS
cord-006229-7yoilsho	2576	3	displayed	display	VBD
cord-006229-7yoilsho	2576	4	loss	loss	NN
cord-006229-7yoilsho	2576	5	of	of	IN
cord-006229-7yoilsho	2576	6	cardiomyocyte	cardiomyocyte	NNP
cord-006229-7yoilsho	2576	7	gene	gene	NN
cord-006229-7yoilsho	2576	8	expression	expression	NN
cord-006229-7yoilsho	2576	9	patterns	pattern	NNS
cord-006229-7yoilsho	2576	10	,	,	,
cord-006229-7yoilsho	2576	11	decreased	decrease	VBD
cord-006229-7yoilsho	2576	12	promotor	promotor	NN
cord-006229-7yoilsho	2576	13	CpG	CpG	NNP
cord-006229-7yoilsho	2576	14	methylation	methylation	NNP
cord-006229-7yoilsho	2576	15	of	of	IN
cord-006229-7yoilsho	2576	16	aberrantly	aberrantly	RB
cord-006229-7yoilsho	2576	17	expressed	express	VBN
cord-006229-7yoilsho	2576	18	genes	gene	NNS
cord-006229-7yoilsho	2576	19	and	and	CC
cord-006229-7yoilsho	2576	20	ultrastructural	ultrastructural	JJ
cord-006229-7yoilsho	2576	21	features	feature	NNS
cord-006229-7yoilsho	2576	22	of	of	IN
cord-006229-7yoilsho	2576	23	wide	wide	JJ
cord-006229-7yoilsho	2576	24	-	-	HYPH
cord-006229-7yoilsho	2576	25	spread	spread	NN
cord-006229-7yoilsho	2576	26	cardiac	cardiac	JJ
cord-006229-7yoilsho	2576	27	myocyte	myocyte	NN
cord-006229-7yoilsho	2576	28	cell	cell	NN
cord-006229-7yoilsho	2576	29	death	death	NN
cord-006229-7yoilsho	2576	30	.	.	.
cord-006229-7yoilsho	2577	1	In	in	IN
cord-006229-7yoilsho	2577	2	contrast	contrast	NN
cord-006229-7yoilsho	2577	3	,	,	,
cord-006229-7yoilsho	2577	4	tamoxifen	tamoxifen	NN
cord-006229-7yoilsho	2577	5	-	-	HYPH
cord-006229-7yoilsho	2577	6	induced	induce	VBN
cord-006229-7yoilsho	2577	7	ablation	ablation	NN
cord-006229-7yoilsho	2577	8	of	of	IN
cord-006229-7yoilsho	2577	9	Dnmt1	Dnmt1	NNP
cord-006229-7yoilsho	2577	10	in	in	IN
cord-006229-7yoilsho	2577	11	adult	adult	NN
cord-006229-7yoilsho	2577	12	mice	mouse	NNS
cord-006229-7yoilsho	2577	13	did	do	VBD
cord-006229-7yoilsho	2577	14	not	not	RB
cord-006229-7yoilsho	2577	15	affect	affect	VB
cord-006229-7yoilsho	2577	16	survival	survival	NN
cord-006229-7yoilsho	2577	17	of	of	IN
cord-006229-7yoilsho	2577	18	KO	KO	NNP
cord-006229-7yoilsho	2577	19	mice	mouse	NNS
cord-006229-7yoilsho	2577	20	.	.	.
cord-006229-7yoilsho	2578	1	Cardiac	cardiac	JJ
cord-006229-7yoilsho	2578	2	phenotyping	phenotyping	NN
cord-006229-7yoilsho	2578	3	of	of	IN
cord-006229-7yoilsho	2578	4	adult	adult	NN
cord-006229-7yoilsho	2578	5	mice	mouse	NNS
cord-006229-7yoilsho	2578	6	revealed	reveal	VBD
cord-006229-7yoilsho	2578	7	no	no	DT
cord-006229-7yoilsho	2578	8	significant	significant	JJ
cord-006229-7yoilsho	2578	9	differences	difference	NNS
cord-006229-7yoilsho	2578	10	between	between	IN
cord-006229-7yoilsho	2578	11	KO	KO	NNP
cord-006229-7yoilsho	2578	12	and	and	CC
cord-006229-7yoilsho	2578	13	CTL	CTL	NNP
cord-006229-7yoilsho	2578	14	mice	mouse	NNS
cord-006229-7yoilsho	2578	15	under	under	IN
cord-006229-7yoilsho	2578	16	sham	sham	NN
cord-006229-7yoilsho	2578	17	and	and	CC
cord-006229-7yoilsho	2578	18	TAC	TAC	NNP
cord-006229-7yoilsho	2578	19	conditions	condition	NNS
cord-006229-7yoilsho	2578	20	.	.	.
cord-006229-7yoilsho	2579	1	Conclusion	conclusion	NN
cord-006229-7yoilsho	2579	2	:	:	:
cord-006229-7yoilsho	2579	3	DNA	dna	NN
cord-006229-7yoilsho	2579	4	methyltransferase	methyltransferase	NN
cord-006229-7yoilsho	2579	5	Dnmt1	Dnmt1	VBN
cord-006229-7yoilsho	2579	6	in	in	IN
cord-006229-7yoilsho	2579	7	embryonic	embryonic	JJ
cord-006229-7yoilsho	2579	8	cardiac	cardiac	JJ
cord-006229-7yoilsho	2579	9	myocytes	myocytes	NN
cord-006229-7yoilsho	2579	10	is	be	VBZ
cord-006229-7yoilsho	2579	11	essential	essential	JJ
cord-006229-7yoilsho	2579	12	for	for	IN
cord-006229-7yoilsho	2579	13	proper	proper	JJ
cord-006229-7yoilsho	2579	14	heart	heart	NN
cord-006229-7yoilsho	2579	15	development	development	NN
cord-006229-7yoilsho	2579	16	.	.	.
cord-006229-7yoilsho	2580	1	In	in	IN
cord-006229-7yoilsho	2580	2	adult	adult	NN
cord-006229-7yoilsho	2580	3	cardiomyocytes	cardiomyocyte	NNS
cord-006229-7yoilsho	2580	4	,	,	,
cord-006229-7yoilsho	2580	5	Dnmt1	Dnmt1	NNP
cord-006229-7yoilsho	2580	6	is	be	VBZ
cord-006229-7yoilsho	2580	7	dispensable	dispensable	JJ
cord-006229-7yoilsho	2580	8	for	for	IN
cord-006229-7yoilsho	2580	9	normal	normal	JJ
cord-006229-7yoilsho	2580	10	cardiac	cardiac	JJ
cord-006229-7yoilsho	2580	11	function	function	NN
cord-006229-7yoilsho	2580	12	and	and	CC
cord-006229-7yoilsho	2580	13	for	for	IN
cord-006229-7yoilsho	2580	14	adaptation	adaptation	NN
cord-006229-7yoilsho	2580	15	to	to	IN
cord-006229-7yoilsho	2580	16	chronic	chronic	JJ
cord-006229-7yoilsho	2580	17	cardiac	cardiac	JJ
cord-006229-7yoilsho	2580	18	pressure	pressure	NN
cord-006229-7yoilsho	2580	19	overload	overload	NN
cord-006229-7yoilsho	2580	20	.	.	.
cord-006229-7yoilsho	2580	21	 	 	_SP
cord-006229-7yoilsho	2581	1	Background	background	NN
cord-006229-7yoilsho	2581	2	:	:	:
cord-006229-7yoilsho	2582	1	Recent	recent	JJ
cord-006229-7yoilsho	2582	2	studies	study	NNS
cord-006229-7yoilsho	2582	3	showed	show	VBD
cord-006229-7yoilsho	2582	4	that	that	IN
cord-006229-7yoilsho	2582	5	mice	mouse	NNS
cord-006229-7yoilsho	2582	6	with	with	IN
cord-006229-7yoilsho	2582	7	general	general	JJ
cord-006229-7yoilsho	2582	8	deletion	deletion	NN
cord-006229-7yoilsho	2582	9	of	of	IN
cord-006229-7yoilsho	2582	10	the	the	DT
cord-006229-7yoilsho	2582	11	oxidoreductase	oxidoreductase	NN
cord-006229-7yoilsho	2582	12	Tet3	Tet3	NNP
cord-006229-7yoilsho	2582	13	involved	involve	VBN
cord-006229-7yoilsho	2582	14	in	in	IN
cord-006229-7yoilsho	2582	15	DNA	dna	NN
cord-006229-7yoilsho	2582	16	demethylation	demethylation	NN
cord-006229-7yoilsho	2582	17	are	be	VBP
cord-006229-7yoilsho	2582	18	embryonic	embryonic	JJ
cord-006229-7yoilsho	2582	19	lethal	lethal	JJ
cord-006229-7yoilsho	2582	20	,	,	,
cord-006229-7yoilsho	2582	21	the	the	DT
cord-006229-7yoilsho	2582	22	underlying	underlying	JJ
cord-006229-7yoilsho	2582	23	cause	cause	NN
cord-006229-7yoilsho	2582	24	remaining	remain	VBG
cord-006229-7yoilsho	2582	25	unknown	unknown	JJ
cord-006229-7yoilsho	2582	26	.	.	.
cord-006229-7yoilsho	2583	1	This	this	DT
cord-006229-7yoilsho	2583	2	prompted	prompt	VBD
cord-006229-7yoilsho	2583	3	us	-PRON-	PRP
cord-006229-7yoilsho	2583	4	to	to	TO
cord-006229-7yoilsho	2583	5	investigate	investigate	VB
cord-006229-7yoilsho	2583	6	wether	wether	PRP
cord-006229-7yoilsho	2583	7	embryonic	embryonic	JJ
cord-006229-7yoilsho	2583	8	lethality	lethality	NN
cord-006229-7yoilsho	2583	9	is	be	VBZ
cord-006229-7yoilsho	2583	10	caused	cause	VBN
cord-006229-7yoilsho	2583	11	by	by	IN
cord-006229-7yoilsho	2583	12	cardiomyocyte	cardiomyocyte	NN
cord-006229-7yoilsho	2583	13	-	-	HYPH
cord-006229-7yoilsho	2583	14	specific	specific	JJ
cord-006229-7yoilsho	2583	15	loss	loss	NN
cord-006229-7yoilsho	2583	16	of	of	IN
cord-006229-7yoilsho	2583	17	Tet3	Tet3	NNP
cord-006229-7yoilsho	2583	18	.	.	.
cord-006229-7yoilsho	2584	1	Methods	method	NNS
cord-006229-7yoilsho	2584	2	:	:	:
cord-006229-7yoilsho	2584	3	Female	female	JJ
cord-006229-7yoilsho	2584	4	mice	mouse	NNS
cord-006229-7yoilsho	2584	5	homozygous	homozygous	JJ
cord-006229-7yoilsho	2584	6	for	for	IN
cord-006229-7yoilsho	2584	7	Tet3	Tet3	NNP
cord-006229-7yoilsho	2584	8	flox	flox	NNP
cord-006229-7yoilsho	2584	9	and	and	CC
cord-006229-7yoilsho	2584	10	male	male	JJ
cord-006229-7yoilsho	2584	11	mice	mouse	NNS
cord-006229-7yoilsho	2584	12	heterozygous	heterozygous	JJ
cord-006229-7yoilsho	2584	13	for	for	IN
cord-006229-7yoilsho	2584	14	Tet3	Tet3	NNP
cord-006229-7yoilsho	2584	15	flox	flox	NNP
cord-006229-7yoilsho	2584	16	and	and	CC
cord-006229-7yoilsho	2584	17	heterozygous	heterozygous	JJ
cord-006229-7yoilsho	2584	18	for	for	IN
cord-006229-7yoilsho	2584	19	Myl7-Cre	Myl7-Cre	NNP
cord-006229-7yoilsho	2584	20	were	be	VBD
cord-006229-7yoilsho	2584	21	mated	mate	VBN
cord-006229-7yoilsho	2584	22	and	and	CC
cord-006229-7yoilsho	2584	23	offspring	offspring	NN
cord-006229-7yoilsho	2584	24	were	be	VBD
cord-006229-7yoilsho	2584	25	genotyped	genotype	VBN
cord-006229-7yoilsho	2584	26	after	after	IN
cord-006229-7yoilsho	2584	27	weaning	wean	VBG
cord-006229-7yoilsho	2584	28	.	.	.
cord-006229-7yoilsho	2585	1	Mice	mouse	NNS
cord-006229-7yoilsho	2585	2	homozygous	homozygous	JJ
cord-006229-7yoilsho	2585	3	for	for	IN
cord-006229-7yoilsho	2585	4	Tet3	Tet3	NNP
cord-006229-7yoilsho	2585	5	flox	flox	NNP
cord-006229-7yoilsho	2585	6	and	and	CC
cord-006229-7yoilsho	2585	7	heterozygous	heterozygous	JJ
cord-006229-7yoilsho	2585	8	for	for	IN
cord-006229-7yoilsho	2585	9	Myl7-Cre	Myl7-Cre	NNP
cord-006229-7yoilsho	2585	10	(	(	-LRB-
cord-006229-7yoilsho	2585	11	KO	KO	NNP
cord-006229-7yoilsho	2585	12	)	)	-RRB-
cord-006229-7yoilsho	2585	13	or	or	CC
cord-006229-7yoilsho	2585	14	homozygous	homozygous	JJ
cord-006229-7yoilsho	2585	15	for	for	IN
cord-006229-7yoilsho	2585	16	Tet3	Tet3	NNP
cord-006229-7yoilsho	2585	17	flox	flox	NNP
cord-006229-7yoilsho	2585	18	without	without	IN
cord-006229-7yoilsho	2585	19	Myl7-Cre	Myl7-Cre	NNP
cord-006229-7yoilsho	2585	20	(	(	-LRB-
cord-006229-7yoilsho	2585	21	controls	control	NNS
cord-006229-7yoilsho	2585	22	)	)	-RRB-
cord-006229-7yoilsho	2585	23	were	be	VBD
cord-006229-7yoilsho	2585	24	sacrificed	sacrifice	VBN
cord-006229-7yoilsho	2585	25	at	at	IN
cord-006229-7yoilsho	2585	26	12	12	CD
cord-006229-7yoilsho	2585	27	weeks	week	NNS
cord-006229-7yoilsho	2585	28	of	of	IN
cord-006229-7yoilsho	2585	29	age	age	NN
cord-006229-7yoilsho	2585	30	and	and	CC
cord-006229-7yoilsho	2585	31	ventricles	ventricle	NNS
cord-006229-7yoilsho	2585	32	were	be	VBD
cord-006229-7yoilsho	2585	33	harvested	harvest	VBN
cord-006229-7yoilsho	2585	34	.	.	.
cord-006229-7yoilsho	2586	1	mRNA	mrna	NN
cord-006229-7yoilsho	2586	2	of	of	IN
cord-006229-7yoilsho	2586	3	the	the	DT
cord-006229-7yoilsho	2586	4	ventricles	ventricle	NNS
cord-006229-7yoilsho	2586	5	was	be	VBD
cord-006229-7yoilsho	2586	6	isolated	isolate	VBN
cord-006229-7yoilsho	2586	7	and	and	CC
cord-006229-7yoilsho	2586	8	expression	expression	NN
cord-006229-7yoilsho	2586	9	of	of	IN
cord-006229-7yoilsho	2586	10	cardiomyocyte	cardiomyocyte	NN
cord-006229-7yoilsho	2586	11	-	-	HYPH
cord-006229-7yoilsho	2586	12	specific	specific	JJ
cord-006229-7yoilsho	2586	13	genes	gene	NNS
cord-006229-7yoilsho	2586	14	was	be	VBD
cord-006229-7yoilsho	2586	15	evaluated	evaluate	VBN
cord-006229-7yoilsho	2586	16	by	by	IN
cord-006229-7yoilsho	2586	17	quantitative	quantitative	JJ
cord-006229-7yoilsho	2586	18	real	real	JJ
cord-006229-7yoilsho	2586	19	-	-	HYPH
cord-006229-7yoilsho	2586	20	time	time	NN
cord-006229-7yoilsho	2586	21	PCR	PCR	NNP
cord-006229-7yoilsho	2586	22	.	.	.
cord-006229-7yoilsho	2587	1	Cardiomyocyte	Cardiomyocyte	NNP
cord-006229-7yoilsho	2587	2	-	-	HYPH
cord-006229-7yoilsho	2587	3	specific	specific	JJ
cord-006229-7yoilsho	2587	4	genomic	genomic	JJ
cord-006229-7yoilsho	2587	5	DNA	dna	NN
cord-006229-7yoilsho	2587	6	from	from	IN
cord-006229-7yoilsho	2587	7	KO	KO	NNP
cord-006229-7yoilsho	2587	8	and	and	CC
cord-006229-7yoilsho	2587	9	control	control	NN
cord-006229-7yoilsho	2587	10	mice	mouse	NNS
cord-006229-7yoilsho	2587	11	was	be	VBD
cord-006229-7yoilsho	2587	12	obtained	obtain	VBN
cord-006229-7yoilsho	2587	13	from	from	IN
cord-006229-7yoilsho	2587	14	FACS	FACS	NNP
cord-006229-7yoilsho	2587	15	-	-	HYPH
cord-006229-7yoilsho	2587	16	sorted	sort	VBN
cord-006229-7yoilsho	2587	17	cardiomyocyte	cardiomyocyte	NN
cord-006229-7yoilsho	2587	18	nuclei	nucleus	NNS
cord-006229-7yoilsho	2587	19	and	and	CC
cord-006229-7yoilsho	2587	20	bisulfite	bisulfite	NN
cord-006229-7yoilsho	2587	21	-	-	HYPH
cord-006229-7yoilsho	2587	22	converted	convert	VBN
cord-006229-7yoilsho	2587	23	for	for	IN
cord-006229-7yoilsho	2587	24	analysis	analysis	NN
cord-006229-7yoilsho	2587	25	of	of	IN
cord-006229-7yoilsho	2587	26	DNA	dna	NN
cord-006229-7yoilsho	2587	27	methylation	methylation	NN
cord-006229-7yoilsho	2587	28	by	by	IN
cord-006229-7yoilsho	2587	29	pyrosequencing	pyrosequence	VBG
cord-006229-7yoilsho	2587	30	.	.	.
cord-006229-7yoilsho	2588	1	Results	result	NNS
cord-006229-7yoilsho	2588	2	:	:	:
cord-006229-7yoilsho	2589	1	KO	KO	NNP
cord-006229-7yoilsho	2589	2	mice	mouse	NNS
cord-006229-7yoilsho	2589	3	showed	show	VBD
cord-006229-7yoilsho	2589	4	embryonic	embryonic	JJ
cord-006229-7yoilsho	2589	5	lethality	lethality	NN
cord-006229-7yoilsho	2589	6	of	of	IN
cord-006229-7yoilsho	2589	7	nearly	nearly	RB
cord-006229-7yoilsho	2589	8	50	50	CD
cord-006229-7yoilsho	2589	9	%	%	NN
cord-006229-7yoilsho	2589	10	.	.	.
cord-006229-7yoilsho	2590	1	Born	bear	VBN
cord-006229-7yoilsho	2590	2	KO	KO	NNP
cord-006229-7yoilsho	2590	3	mice	mouse	NNS
cord-006229-7yoilsho	2590	4	developed	develop	VBN
cord-006229-7yoilsho	2590	5	without	without	IN
cord-006229-7yoilsho	2590	6	phenotypic	phenotypic	JJ
cord-006229-7yoilsho	2590	7	abnormalities	abnormality	NNS
cord-006229-7yoilsho	2590	8	(	(	-LRB-
cord-006229-7yoilsho	2590	9	normal	normal	JJ
cord-006229-7yoilsho	2590	10	heart	heart	NN
cord-006229-7yoilsho	2590	11	weight	weight	NN
cord-006229-7yoilsho	2590	12	/	/	SYM
cord-006229-7yoilsho	2590	13	tibia	tibia	NN
cord-006229-7yoilsho	2590	14	length	length	NN
cord-006229-7yoilsho	2590	15	ratio	ratio	NN
cord-006229-7yoilsho	2590	16	)	)	-RRB-
cord-006229-7yoilsho	2590	17	and	and	CC
cord-006229-7yoilsho	2590	18	displayed	display	VBD
cord-006229-7yoilsho	2590	19	compensatory	compensatory	JJ
cord-006229-7yoilsho	2590	20	upregulation	upregulation	NN
cord-006229-7yoilsho	2590	21	of	of	IN
cord-006229-7yoilsho	2590	22	Tet1	Tet1	NNP
cord-006229-7yoilsho	2590	23	and	and	CC
cord-006229-7yoilsho	2590	24	Tet2	Tet2	NNP
cord-006229-7yoilsho	2590	25	.	.	.
cord-006229-7yoilsho	2591	1	Cardiomyocyte	Cardiomyocyte	NNP
cord-006229-7yoilsho	2591	2	genomic	genomic	JJ
cord-006229-7yoilsho	2591	3	DNA	dna	NN
cord-006229-7yoilsho	2591	4	of	of	IN
cord-006229-7yoilsho	2591	5	KO	KO	NNP
cord-006229-7yoilsho	2591	6	mice	mouse	NNS
cord-006229-7yoilsho	2591	7	showed	show	VBD
cord-006229-7yoilsho	2591	8	significantly	significantly	RB
cord-006229-7yoilsho	2591	9	higher	high	JJR
cord-006229-7yoilsho	2591	10	methylation	methylation	NN
cord-006229-7yoilsho	2591	11	levels	level	NNS
cord-006229-7yoilsho	2591	12	in	in	IN
cord-006229-7yoilsho	2591	13	the	the	DT
cord-006229-7yoilsho	2591	14	body	body	NN
cord-006229-7yoilsho	2591	15	of	of	IN
cord-006229-7yoilsho	2591	16	the	the	DT
cord-006229-7yoilsho	2591	17	Atp2a2	Atp2a2	NNP
cord-006229-7yoilsho	2591	18	gene	gene	NN
cord-006229-7yoilsho	2591	19	and	and	CC
cord-006229-7yoilsho	2591	20	at	at	IN
cord-006229-7yoilsho	2591	21	the	the	DT
cord-006229-7yoilsho	2591	22	binding	binding	NN
cord-006229-7yoilsho	2591	23	site	site	NN
cord-006229-7yoilsho	2591	24	of	of	IN
cord-006229-7yoilsho	2591	25	the	the	DT
cord-006229-7yoilsho	2591	26	transcription	transcription	NN
cord-006229-7yoilsho	2591	27	factor	factor	NN
cord-006229-7yoilsho	2591	28	GATA4	gata4	RB
cord-006229-7yoilsho	2591	29	but	but	CC
cord-006229-7yoilsho	2591	30	not	not	RB
cord-006229-7yoilsho	2591	31	near	near	IN
cord-006229-7yoilsho	2591	32	the	the	DT
cord-006229-7yoilsho	2591	33	promotor	promotor	NN
cord-006229-7yoilsho	2591	34	and	and	CC
cord-006229-7yoilsho	2591	35	the	the	DT
cord-006229-7yoilsho	2591	36	binding	binding	NN
cord-006229-7yoilsho	2591	37	site	site	NN
cord-006229-7yoilsho	2591	38	of	of	IN
cord-006229-7yoilsho	2591	39	the	the	DT
cord-006229-7yoilsho	2591	40	transcription	transcription	NN
cord-006229-7yoilsho	2591	41	factor	factor	NN
cord-006229-7yoilsho	2591	42	TBX5	TBX5	NNP
cord-006229-7yoilsho	2591	43	.	.	.
cord-006229-7yoilsho	2592	1	Higher	high	JJR
cord-006229-7yoilsho	2592	2	methylation	methylation	NN
cord-006229-7yoilsho	2592	3	levels	level	NNS
cord-006229-7yoilsho	2592	4	were	be	VBD
cord-006229-7yoilsho	2592	5	not	not	RB
cord-006229-7yoilsho	2592	6	accompanied	accompany	VBN
cord-006229-7yoilsho	2592	7	by	by	IN
cord-006229-7yoilsho	2592	8	changes	change	NNS
cord-006229-7yoilsho	2592	9	in	in	IN
cord-006229-7yoilsho	2592	10	Atp2a2	atp2a2	DT
cord-006229-7yoilsho	2592	11	expression	expression	NN
cord-006229-7yoilsho	2592	12	.	.	.
cord-006229-7yoilsho	2593	1	However	however	RB
cord-006229-7yoilsho	2593	2	,	,	,
cord-006229-7yoilsho	2593	3	both	both	CC
cord-006229-7yoilsho	2593	4	Myh7	Myh7	NNP
cord-006229-7yoilsho	2593	5	and	and	CC
cord-006229-7yoilsho	2593	6	Nppb	Nppb	NNP
cord-006229-7yoilsho	2593	7	were	be	VBD
cord-006229-7yoilsho	2593	8	upregulated	upregulate	VBN
cord-006229-7yoilsho	2593	9	in	in	IN
cord-006229-7yoilsho	2593	10	KO	KO	NNP
cord-006229-7yoilsho	2593	11	mice	mouse	NNS
cord-006229-7yoilsho	2593	12	compared	compare	VBN
cord-006229-7yoilsho	2593	13	to	to	TO
cord-006229-7yoilsho	2593	14	control	control	NN
cord-006229-7yoilsho	2593	15	mice	mouse	NNS
cord-006229-7yoilsho	2593	16	.	.	.
cord-006229-7yoilsho	2594	1	Conclusions	conclusion	NNS
cord-006229-7yoilsho	2594	2	:	:	:
cord-006229-7yoilsho	2595	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	2595	2	findings	finding	NNS
cord-006229-7yoilsho	2595	3	suggest	suggest	VBP
cord-006229-7yoilsho	2595	4	that	that	IN
cord-006229-7yoilsho	2595	5	Tet3	Tet3	NNP
cord-006229-7yoilsho	2595	6	is	be	VBZ
cord-006229-7yoilsho	2595	7	involved	involve	VBN
cord-006229-7yoilsho	2595	8	in	in	IN
cord-006229-7yoilsho	2595	9	DNA	dna	NN
cord-006229-7yoilsho	2595	10	demethylation	demethylation	NN
cord-006229-7yoilsho	2595	11	in	in	IN
cord-006229-7yoilsho	2595	12	cardiomyocytes	cardiomyocyte	NNS
cord-006229-7yoilsho	2595	13	.	.	.
cord-006229-7yoilsho	2596	1	Loss	loss	NN
cord-006229-7yoilsho	2596	2	of	of	IN
cord-006229-7yoilsho	2596	3	Tet3	Tet3	NNP
cord-006229-7yoilsho	2596	4	expression	expression	NN
cord-006229-7yoilsho	2596	5	resulted	result	VBD
cord-006229-7yoilsho	2596	6	in	in	IN
cord-006229-7yoilsho	2596	7	embryonic	embryonic	JJ
cord-006229-7yoilsho	2596	8	lethality	lethality	NN
cord-006229-7yoilsho	2596	9	.	.	.
cord-006229-7yoilsho	2597	1	Compensatory	compensatory	JJ
cord-006229-7yoilsho	2597	2	upregulation	upregulation	NN
cord-006229-7yoilsho	2597	3	of	of	IN
cord-006229-7yoilsho	2597	4	Tet1	Tet1	NNP
cord-006229-7yoilsho	2597	5	and	and	CC
cord-006229-7yoilsho	2597	6	Tet2	Tet2	NNP
cord-006229-7yoilsho	2597	7	isoenzymes	isoenzyme	NNS
cord-006229-7yoilsho	2597	8	may	may	MD
cord-006229-7yoilsho	2597	9	contribute	contribute	VB
cord-006229-7yoilsho	2597	10	to	to	IN
cord-006229-7yoilsho	2597	11	the	the	DT
cord-006229-7yoilsho	2597	12	incomplete	incomplete	JJ
cord-006229-7yoilsho	2597	13	penetrance	penetrance	NN
cord-006229-7yoilsho	2597	14	of	of	IN
cord-006229-7yoilsho	2597	15	this	this	DT
cord-006229-7yoilsho	2597	16	phenotype	phenotype	NN
cord-006229-7yoilsho	2597	17	.	.	.
cord-006229-7yoilsho	2598	1	Further	further	JJ
cord-006229-7yoilsho	2598	2	studies	study	NNS
cord-006229-7yoilsho	2598	3	are	be	VBP
cord-006229-7yoilsho	2598	4	ongoing	ongoing	JJ
cord-006229-7yoilsho	2598	5	to	to	TO
cord-006229-7yoilsho	2598	6	investigate	investigate	VB
cord-006229-7yoilsho	2598	7	the	the	DT
cord-006229-7yoilsho	2598	8	functional	functional	JJ
cord-006229-7yoilsho	2598	9	relevance	relevance	NN
cord-006229-7yoilsho	2598	10	of	of	IN
cord-006229-7yoilsho	2598	11	Tet3	Tet3	NNP
cord-006229-7yoilsho	2598	12	in	in	IN
cord-006229-7yoilsho	2598	13	cardiomyocytes	cardiomyocyte	NNS
cord-006229-7yoilsho	2598	14	.	.	.
cord-006229-7yoilsho	2599	1	To	to	TO
cord-006229-7yoilsho	2599	2	identify	identify	VB
cord-006229-7yoilsho	2599	3	novel	novel	JJ
cord-006229-7yoilsho	2599	4	proteins	protein	NNS
cord-006229-7yoilsho	2599	5	secreted	secrete	VBN
cord-006229-7yoilsho	2599	6	by	by	IN
cord-006229-7yoilsho	2599	7	the	the	DT
cord-006229-7yoilsho	2599	8	myocardium	myocardium	NN
cord-006229-7yoilsho	2599	9	,	,	,
cord-006229-7yoilsho	2599	10	we	-PRON-	PRP
cord-006229-7yoilsho	2599	11	have	have	VBP
cord-006229-7yoilsho	2599	12	previously	previously	RB
cord-006229-7yoilsho	2599	13	conducted	conduct	VBN
cord-006229-7yoilsho	2599	14	a	a	DT
cord-006229-7yoilsho	2599	15	genetic	genetic	JJ
cord-006229-7yoilsho	2599	16	screen	screen	NN
cord-006229-7yoilsho	2599	17	,	,	,
cord-006229-7yoilsho	2599	18	which	which	WDT
cord-006229-7yoilsho	2599	19	led	lead	VBD
cord-006229-7yoilsho	2599	20	to	to	IN
cord-006229-7yoilsho	2599	21	the	the	DT
cord-006229-7yoilsho	2599	22	identification	identification	NN
cord-006229-7yoilsho	2599	23	of	of	IN
cord-006229-7yoilsho	2599	24	protease	protease	NN
cord-006229-7yoilsho	2599	25	inhibitor	inhibitor	NN
cord-006229-7yoilsho	2599	26	16	16	CD
cord-006229-7yoilsho	2599	27	(	(	-LRB-
cord-006229-7yoilsho	2599	28	Pi16	Pi16	NNP
cord-006229-7yoilsho	2599	29	)	)	-RRB-
cord-006229-7yoilsho	2599	30	.	.	.
cord-006229-7yoilsho	2600	1	A	a	DT
cord-006229-7yoilsho	2600	2	recent	recent	JJ
cord-006229-7yoilsho	2600	3	GWAS	GWAS	NNP
cord-006229-7yoilsho	2600	4	analysis	analysis	NN
cord-006229-7yoilsho	2600	5	showed	show	VBD
cord-006229-7yoilsho	2600	6	an	an	DT
cord-006229-7yoilsho	2600	7	association	association	NN
cord-006229-7yoilsho	2600	8	of	of	IN
cord-006229-7yoilsho	2600	9	a	a	DT
cord-006229-7yoilsho	2600	10	genetic	genetic	JJ
cord-006229-7yoilsho	2600	11	variant	variant	NN
cord-006229-7yoilsho	2600	12	in	in	IN
cord-006229-7yoilsho	2600	13	the	the	DT
cord-006229-7yoilsho	2600	14	Pi16	pi16	JJ
cord-006229-7yoilsho	2600	15	genomic	genomic	JJ
cord-006229-7yoilsho	2600	16	locus	locus	NN
cord-006229-7yoilsho	2600	17	(	(	-LRB-
cord-006229-7yoilsho	2600	18	rs1405069	rs1405069	NNP
cord-006229-7yoilsho	2600	19	)	)	-RRB-
cord-006229-7yoilsho	2600	20	with	with	IN
cord-006229-7yoilsho	2600	21	chemerin	chemerin	NN
cord-006229-7yoilsho	2600	22	plasma	plasma	NN
cord-006229-7yoilsho	2600	23	levels	level	NNS
cord-006229-7yoilsho	2600	24	.	.	.
cord-006229-7yoilsho	2601	1	Here	here	RB
cord-006229-7yoilsho	2601	2	we	-PRON-	PRP
cord-006229-7yoilsho	2601	3	tested	test	VBD
cord-006229-7yoilsho	2601	4	the	the	DT
cord-006229-7yoilsho	2601	5	hypothesis	hypothesis	NN
cord-006229-7yoilsho	2601	6	that	that	WDT
cord-006229-7yoilsho	2601	7	Pi16	Pi16	NNP
cord-006229-7yoilsho	2601	8	determines	determine	VBZ
cord-006229-7yoilsho	2601	9	chemerin	chemerin	NN
cord-006229-7yoilsho	2601	10	plasma	plasma	NN
cord-006229-7yoilsho	2601	11	levels	level	NNS
cord-006229-7yoilsho	2601	12	through	through	IN
cord-006229-7yoilsho	2601	13	regulation	regulation	NN
cord-006229-7yoilsho	2601	14	of	of	IN
cord-006229-7yoilsho	2601	15	chemerin	chemerin	NNP
cord-006229-7yoilsho	2601	16	processing	processing	NN
cord-006229-7yoilsho	2601	17	.	.	.
cord-006229-7yoilsho	2602	1	We	-PRON-	PRP
cord-006229-7yoilsho	2602	2	generated	generate	VBD
cord-006229-7yoilsho	2602	3	mice	mouse	NNS
cord-006229-7yoilsho	2602	4	deficient	deficient	JJ
cord-006229-7yoilsho	2602	5	for	for	IN
cord-006229-7yoilsho	2602	6	Pi16	pi16	NN
cord-006229-7yoilsho	2602	7	,	,	,
cord-006229-7yoilsho	2602	8	which	which	WDT
cord-006229-7yoilsho	2602	9	did	do	VBD
cord-006229-7yoilsho	2602	10	not	not	RB
cord-006229-7yoilsho	2602	11	display	display	VB
cord-006229-7yoilsho	2602	12	an	an	DT
cord-006229-7yoilsho	2602	13	overt	overt	JJ
cord-006229-7yoilsho	2602	14	phenotype	phenotype	NN
cord-006229-7yoilsho	2602	15	under	under	IN
cord-006229-7yoilsho	2602	16	basal	basal	NN
cord-006229-7yoilsho	2602	17	conditions	condition	NNS
cord-006229-7yoilsho	2602	18	.	.	.
cord-006229-7yoilsho	2603	1	Plasma	plasma	NN
cord-006229-7yoilsho	2603	2	levels	level	NNS
cord-006229-7yoilsho	2603	3	of	of	IN
cord-006229-7yoilsho	2603	4	chemerin	chemerin	NNP
cord-006229-7yoilsho	2603	5	were	be	VBD
cord-006229-7yoilsho	2603	6	found	find	VBN
cord-006229-7yoilsho	2603	7	significantly	significantly	RB
cord-006229-7yoilsho	2603	8	lower	low	JJR
cord-006229-7yoilsho	2603	9	in	in	IN
cord-006229-7yoilsho	2603	10	Pi16-deficient	Pi16-deficient	NNP
cord-006229-7yoilsho	2603	11	animals	animal	NNS
cord-006229-7yoilsho	2603	12	compared	compare	VBN
cord-006229-7yoilsho	2603	13	to	to	IN
cord-006229-7yoilsho	2603	14	littermate	littermate	NN
cord-006229-7yoilsho	2603	15	controls	control	NNS
cord-006229-7yoilsho	2603	16	.	.	.
cord-006229-7yoilsho	2604	1	To	to	TO
cord-006229-7yoilsho	2604	2	investigate	investigate	VB
cord-006229-7yoilsho	2604	3	whether	whether	IN
cord-006229-7yoilsho	2604	4	Pi16	Pi16	NNP
cord-006229-7yoilsho	2604	5	and	and	CC
cord-006229-7yoilsho	2604	6	chemerin	chemerin	NNP
cord-006229-7yoilsho	2604	7	interact	interact	VBP
cord-006229-7yoilsho	2604	8	,	,	,
cord-006229-7yoilsho	2604	9	we	-PRON-	PRP
cord-006229-7yoilsho	2604	10	performed	perform	VBD
cord-006229-7yoilsho	2604	11	co	co	JJ
cord-006229-7yoilsho	2604	12	-	-	JJ
cord-006229-7yoilsho	2604	13	immunoprecipitation	immunoprecipitation	JJ
cord-006229-7yoilsho	2604	14	experiments	experiment	NNS
cord-006229-7yoilsho	2604	15	.	.	.
cord-006229-7yoilsho	2605	1	Indeed	indeed	RB
cord-006229-7yoilsho	2605	2	,	,	,
cord-006229-7yoilsho	2605	3	we	-PRON-	PRP
cord-006229-7yoilsho	2605	4	found	find	VBD
cord-006229-7yoilsho	2605	5	Pi16	pi16	JJ
cord-006229-7yoilsho	2605	6	to	to	TO
cord-006229-7yoilsho	2605	7	co	co	VB
cord-006229-7yoilsho	2605	8	-	-	VB
cord-006229-7yoilsho	2605	9	precipitate	precipitate	VB
cord-006229-7yoilsho	2605	10	with	with	IN
cord-006229-7yoilsho	2605	11	chemerin	chemerin	NN
cord-006229-7yoilsho	2605	12	from	from	IN
cord-006229-7yoilsho	2605	13	both	both	CC
cord-006229-7yoilsho	2605	14	murine	murine	JJ
cord-006229-7yoilsho	2605	15	plasma	plasma	NN
cord-006229-7yoilsho	2605	16	and	and	CC
cord-006229-7yoilsho	2605	17	cell	cell	NN
cord-006229-7yoilsho	2605	18	culture	culture	NN
cord-006229-7yoilsho	2605	19	supernatants	supernatant	NNS
cord-006229-7yoilsho	2605	20	.	.	.
cord-006229-7yoilsho	2606	1	As	as	IN
cord-006229-7yoilsho	2606	2	chemerin	chemerin	NNP
cord-006229-7yoilsho	2606	3	is	be	VBZ
cord-006229-7yoilsho	2606	4	proteolytically	proteolytically	RB
cord-006229-7yoilsho	2606	5	processed	process	VBN
cord-006229-7yoilsho	2606	6	and	and	CC
cord-006229-7yoilsho	2606	7	activated	activate	VBN
cord-006229-7yoilsho	2606	8	,	,	,
cord-006229-7yoilsho	2606	9	we	-PRON-	PRP
cord-006229-7yoilsho	2606	10	next	next	RB
cord-006229-7yoilsho	2606	11	asked	ask	VBD
cord-006229-7yoilsho	2606	12	whether	whether	IN
cord-006229-7yoilsho	2606	13	the	the	DT
cord-006229-7yoilsho	2606	14	presence	presence	NN
cord-006229-7yoilsho	2606	15	of	of	IN
cord-006229-7yoilsho	2606	16	Pi16	Pi16	NNP
cord-006229-7yoilsho	2606	17	would	would	MD
cord-006229-7yoilsho	2606	18	affect	affect	VB
cord-006229-7yoilsho	2606	19	the	the	DT
cord-006229-7yoilsho	2606	20	processing	processing	NN
cord-006229-7yoilsho	2606	21	of	of	IN
cord-006229-7yoilsho	2606	22	pro	pro	JJ
cord-006229-7yoilsho	2606	23	-	-	JJ
cord-006229-7yoilsho	2606	24	chemerin	chemerin	JJ
cord-006229-7yoilsho	2606	25	to	to	IN
cord-006229-7yoilsho	2606	26	its	-PRON-	PRP$
cord-006229-7yoilsho	2606	27	processed	process	VBN
cord-006229-7yoilsho	2606	28	forms	form	NNS
cord-006229-7yoilsho	2606	29	in	in	IN
cord-006229-7yoilsho	2606	30	native	native	JJ
cord-006229-7yoilsho	2606	31	tissue	tissue	NN
cord-006229-7yoilsho	2606	32	.	.	.
cord-006229-7yoilsho	2607	1	Western	western	JJ
cord-006229-7yoilsho	2607	2	blot	blot	NN
cord-006229-7yoilsho	2607	3	analysis	analysis	NN
cord-006229-7yoilsho	2607	4	on	on	IN
cord-006229-7yoilsho	2607	5	cardiac	cardiac	JJ
cord-006229-7yoilsho	2607	6	and	and	CC
cord-006229-7yoilsho	2607	7	adipose	adipose	JJ
cord-006229-7yoilsho	2607	8	tissue	tissue	NN
cord-006229-7yoilsho	2607	9	lysates	lysate	NNS
cord-006229-7yoilsho	2607	10	that	that	WDT
cord-006229-7yoilsho	2607	11	detected	detect	VBD
cord-006229-7yoilsho	2607	12	both	both	CC
cord-006229-7yoilsho	2607	13	the	the	DT
cord-006229-7yoilsho	2607	14	unprocessed	unprocessed	JJ
cord-006229-7yoilsho	2607	15	precursor	precursor	NN
cord-006229-7yoilsho	2607	16	and	and	CC
cord-006229-7yoilsho	2607	17	the	the	DT
cord-006229-7yoilsho	2607	18	processed	process	VBN
cord-006229-7yoilsho	2607	19	forms	form	NNS
cord-006229-7yoilsho	2607	20	of	of	IN
cord-006229-7yoilsho	2607	21	chemerin	chemerin	NNP
cord-006229-7yoilsho	2607	22	showed	show	VBD
cord-006229-7yoilsho	2607	23	a	a	DT
cord-006229-7yoilsho	2607	24	significant	significant	JJ
cord-006229-7yoilsho	2607	25	shift	shift	NN
cord-006229-7yoilsho	2607	26	towards	towards	IN
cord-006229-7yoilsho	2607	27	the	the	DT
cord-006229-7yoilsho	2607	28	processed	process	VBN
cord-006229-7yoilsho	2607	29	forms	form	NNS
cord-006229-7yoilsho	2607	30	upon	upon	IN
cord-006229-7yoilsho	2607	31	genetic	genetic	JJ
cord-006229-7yoilsho	2607	32	deletion	deletion	NN
cord-006229-7yoilsho	2607	33	of	of	IN
cord-006229-7yoilsho	2607	34	Pi16	Pi16	NNP
cord-006229-7yoilsho	2607	35	.	.	.
cord-006229-7yoilsho	2608	1	When	when	WRB
cord-006229-7yoilsho	2608	2	we	-PRON-	PRP
cord-006229-7yoilsho	2608	3	assayed	assay	VBD
cord-006229-7yoilsho	2608	4	for	for	IN
cord-006229-7yoilsho	2608	5	the	the	DT
cord-006229-7yoilsho	2608	6	activity	activity	NN
cord-006229-7yoilsho	2608	7	of	of	IN
cord-006229-7yoilsho	2608	8	the	the	DT
cord-006229-7yoilsho	2608	9	chemerincleaving	chemerincleaving	NN
cord-006229-7yoilsho	2608	10	protease	protease	NN
cord-006229-7yoilsho	2608	11	cathepsin	cathepsin	NN
cord-006229-7yoilsho	2608	12	K	K	NNP
cord-006229-7yoilsho	2608	13	,	,	,
cord-006229-7yoilsho	2608	14	we	-PRON-	PRP
cord-006229-7yoilsho	2608	15	found	find	VBD
cord-006229-7yoilsho	2608	16	recombinant	recombinant	JJ
cord-006229-7yoilsho	2608	17	Pi16	Pi16	NNP
cord-006229-7yoilsho	2609	1	to	to	TO
cord-006229-7yoilsho	2609	2	potently	potently	RB
cord-006229-7yoilsho	2609	3	inhibit	inhibit	VB
cord-006229-7yoilsho	2609	4	cathepsin	cathepsin	NN
cord-006229-7yoilsho	2609	5	K	k	NN
cord-006229-7yoilsho	2609	6	activity	activity	NN
cord-006229-7yoilsho	2609	7	.	.	.
cord-006229-7yoilsho	2610	1	Taken	take	VBN
cord-006229-7yoilsho	2610	2	together	together	RB
cord-006229-7yoilsho	2610	3	,	,	,
cord-006229-7yoilsho	2610	4	we	-PRON-	PRP
cord-006229-7yoilsho	2610	5	propose	propose	VBP
cord-006229-7yoilsho	2610	6	Pi16	pi16	NN
cord-006229-7yoilsho	2610	7	to	to	TO
cord-006229-7yoilsho	2610	8	act	act	VB
cord-006229-7yoilsho	2610	9	as	as	IN
cord-006229-7yoilsho	2610	10	a	a	DT
cord-006229-7yoilsho	2610	11	regulator	regulator	NN
cord-006229-7yoilsho	2610	12	of	of	IN
cord-006229-7yoilsho	2610	13	chemerin	chemerin	NNP
cord-006229-7yoilsho	2610	14	processing	processing	NN
cord-006229-7yoilsho	2610	15	.	.	.
cord-006229-7yoilsho	2611	1	The	the	DT
cord-006229-7yoilsho	2611	2	transient	transient	JJ
cord-006229-7yoilsho	2611	3	receptor	receptor	NN
cord-006229-7yoilsho	2611	4	potential	potential	JJ
cord-006229-7yoilsho	2611	5	canonical	canonical	JJ
cord-006229-7yoilsho	2611	6	6	6	CD
cord-006229-7yoilsho	2611	7	(	(	-LRB-
cord-006229-7yoilsho	2611	8	TRPC6	TRPC6	NNP
cord-006229-7yoilsho	2611	9	)	)	-RRB-
cord-006229-7yoilsho	2611	10	is	be	VBZ
cord-006229-7yoilsho	2611	11	a	a	DT
cord-006229-7yoilsho	2611	12	second	second	JJ
cord-006229-7yoilsho	2611	13	messenger	messenger	NN
cord-006229-7yoilsho	2611	14	-	-	HYPH
cord-006229-7yoilsho	2611	15	gated	gate	VBN
cord-006229-7yoilsho	2611	16	cation	cation	NN
cord-006229-7yoilsho	2611	17	channel	channel	NN
cord-006229-7yoilsho	2611	18	,	,	,
cord-006229-7yoilsho	2611	19	which	which	WDT
cord-006229-7yoilsho	2611	20	mediates	mediate	VBZ
cord-006229-7yoilsho	2611	21	depolarization	depolarization	NN
cord-006229-7yoilsho	2611	22	and	and	CC
cord-006229-7yoilsho	2611	23	Ca	Ca	NNP
cord-006229-7yoilsho	2611	24	2	2	CD
cord-006229-7yoilsho	2611	25	+	+	CC
cord-006229-7yoilsho	2611	26	entry	entry	NN
cord-006229-7yoilsho	2611	27	.	.	.
cord-006229-7yoilsho	2612	1	It	-PRON-	PRP
cord-006229-7yoilsho	2612	2	is	be	VBZ
cord-006229-7yoilsho	2612	3	known	know	VBN
cord-006229-7yoilsho	2612	4	to	to	TO
cord-006229-7yoilsho	2612	5	be	be	VB
cord-006229-7yoilsho	2612	6	activated	activate	VBN
cord-006229-7yoilsho	2612	7	by	by	IN
cord-006229-7yoilsho	2612	8	diacylglycerol	diacylglycerol	NN
cord-006229-7yoilsho	2612	9	derivatives	derivative	NNS
cord-006229-7yoilsho	2612	10	(	(	-LRB-
cord-006229-7yoilsho	2612	11	DAG	DAG	NNP
cord-006229-7yoilsho	2612	12	,	,	,
cord-006229-7yoilsho	2612	13	1-oleoyl-1-acetyl	1-oleoyl-1-acetyl	CD
cord-006229-7yoilsho	2612	14	-	-	HYPH
cord-006229-7yoilsho	2612	15	sn	sn	NN
cord-006229-7yoilsho	2612	16	-	-	HYPH
cord-006229-7yoilsho	2612	17	glycerol	glycerol	JJ
cord-006229-7yoilsho	2612	18	OAG	OAG	NNP
cord-006229-7yoilsho	2612	19	)	)	-RRB-
cord-006229-7yoilsho	2613	1	[	[	-LRB-
cord-006229-7yoilsho	2613	2	1	1	CD
cord-006229-7yoilsho	2613	3	]	]	-RRB-
cord-006229-7yoilsho	2613	4	in	in	IN
cord-006229-7yoilsho	2613	5	a	a	DT
cord-006229-7yoilsho	2613	6	PKC	PKC	NNP
cord-006229-7yoilsho	2613	7	-	-	HYPH
cord-006229-7yoilsho	2613	8	independent	independent	JJ
cord-006229-7yoilsho	2613	9	manner	manner	NN
cord-006229-7yoilsho	2613	10	and	and	CC
cord-006229-7yoilsho	2613	11	plays	play	VBZ
cord-006229-7yoilsho	2613	12	important	important	JJ
cord-006229-7yoilsho	2613	13	roles	role	NNS
cord-006229-7yoilsho	2613	14	in	in	IN
cord-006229-7yoilsho	2613	15	lung	lung	NN
cord-006229-7yoilsho	2613	16	and	and	CC
cord-006229-7yoilsho	2613	17	kidney	kidney	NN
cord-006229-7yoilsho	2613	18	physiology	physiology	NN
cord-006229-7yoilsho	2613	19	.	.	.
cord-006229-7yoilsho	2614	1	Gain	gain	NN
cord-006229-7yoilsho	2614	2	-	-	HYPH
cord-006229-7yoilsho	2614	3	of	of	IN
cord-006229-7yoilsho	2614	4	-	-	HYPH
cord-006229-7yoilsho	2614	5	function	function	NN
cord-006229-7yoilsho	2614	6	mutations	mutation	NNS
cord-006229-7yoilsho	2614	7	in	in	IN
cord-006229-7yoilsho	2614	8	the	the	DT
cord-006229-7yoilsho	2614	9	TRPC6	TRPC6	NNP
cord-006229-7yoilsho	2614	10	gene	gene	NN
cord-006229-7yoilsho	2614	11	can	can	MD
cord-006229-7yoilsho	2614	12	cause	cause	VB
cord-006229-7yoilsho	2614	13	focal	focal	JJ
cord-006229-7yoilsho	2614	14	segmental	segmental	JJ
cord-006229-7yoilsho	2614	15	glomerulosclerosis	glomerulosclerosis	NN
cord-006229-7yoilsho	2614	16	(	(	-LRB-
cord-006229-7yoilsho	2614	17	FSGS	FSGS	NNP
cord-006229-7yoilsho	2614	18	)	)	-RRB-
cord-006229-7yoilsho	2614	19	,	,	,
cord-006229-7yoilsho	2614	20	a	a	DT
cord-006229-7yoilsho	2614	21	kidney	kidney	NN
cord-006229-7yoilsho	2614	22	dysfunction	dysfunction	NN
cord-006229-7yoilsho	2614	23	leading	lead	VBG
cord-006229-7yoilsho	2614	24	to	to	IN
cord-006229-7yoilsho	2614	25	end	end	VB
cord-006229-7yoilsho	2614	26	stage	stage	NN
cord-006229-7yoilsho	2614	27	renal	renal	JJ
cord-006229-7yoilsho	2614	28	disease	disease	NN
cord-006229-7yoilsho	2614	29	.	.	.
cord-006229-7yoilsho	2615	1	[	[	-LRB-
cord-006229-7yoilsho	2615	2	2	2	CD
cord-006229-7yoilsho	2615	3	]	]	-RRB-
cord-006229-7yoilsho	2616	1	Thus	thus	RB
cord-006229-7yoilsho	2616	2	,	,	,
cord-006229-7yoilsho	2616	3	the	the	DT
cord-006229-7yoilsho	2616	4	discovery	discovery	NN
cord-006229-7yoilsho	2616	5	of	of	IN
cord-006229-7yoilsho	2616	6	potent	potent	JJ
cord-006229-7yoilsho	2616	7	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	2616	8	of	of	IN
cord-006229-7yoilsho	2616	9	TRPC6	TRPC6	NNP
cord-006229-7yoilsho	2616	10	may	may	MD
cord-006229-7yoilsho	2616	11	help	help	VB
cord-006229-7yoilsho	2616	12	to	to	TO
cord-006229-7yoilsho	2616	13	develop	develop	VB
cord-006229-7yoilsho	2616	14	new	new	JJ
cord-006229-7yoilsho	2616	15	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	2616	16	strategies	strategy	NNS
cord-006229-7yoilsho	2616	17	.	.	.
cord-006229-7yoilsho	2617	1	Urban	Urban	NNP
cord-006229-7yoilsho	2617	2	et	et	NNP
cord-006229-7yoilsho	2617	3	al	al	NNP
cord-006229-7yoilsho	2617	4	.	.	NNP
cord-006229-7yoilsho	2617	5	discovered	discover	VBD
cord-006229-7yoilsho	2617	6	that	that	IN
cord-006229-7yoilsho	2617	7	larixol	larixol	NNP
cord-006229-7yoilsho	2617	8	,	,	,
cord-006229-7yoilsho	2617	9	a	a	DT
cord-006229-7yoilsho	2617	10	natural	natural	JJ
cord-006229-7yoilsho	2617	11	product	product	NN
cord-006229-7yoilsho	2617	12	with	with	IN
cord-006229-7yoilsho	2617	13	a	a	DT
cord-006229-7yoilsho	2617	14	labdane	labdane	NNP
cord-006229-7yoilsho	2617	15	skeleton	skeleton	NN
cord-006229-7yoilsho	2617	16	found	find	VBN
cord-006229-7yoilsho	2617	17	in	in	IN
cord-006229-7yoilsho	2617	18	the	the	DT
cord-006229-7yoilsho	2617	19	oleoresin	oleoresin	NN
cord-006229-7yoilsho	2617	20	of	of	IN
cord-006229-7yoilsho	2617	21	the	the	DT
cord-006229-7yoilsho	2617	22	European	european	JJ
cord-006229-7yoilsho	2617	23	larch	larch	NN
cord-006229-7yoilsho	2617	24	(	(	-LRB-
cord-006229-7yoilsho	2617	25	Larix	Larix	NNP
cord-006229-7yoilsho	2617	26	decidua	decidua	NN
cord-006229-7yoilsho	2617	27	)	)	-RRB-
cord-006229-7yoilsho	2617	28	,	,	,
cord-006229-7yoilsho	2617	29	blocks	block	VBZ
cord-006229-7yoilsho	2617	30	the	the	DT
cord-006229-7yoilsho	2617	31	OAG	OAG	NNP
cord-006229-7yoilsho	2617	32	-	-	HYPH
cord-006229-7yoilsho	2617	33	dependent	dependent	JJ
cord-006229-7yoilsho	2617	34	activation	activation	NN
cord-006229-7yoilsho	2617	35	of	of	IN
cord-006229-7yoilsho	2617	36	TRPC6	TRPC6	NNP
cord-006229-7yoilsho	2617	37	.	.	.
cord-006229-7yoilsho	2618	1	[	[	-LRB-
cord-006229-7yoilsho	2618	2	3	3	CD
cord-006229-7yoilsho	2618	3	]	]	-RRB-
cord-006229-7yoilsho	2618	4	Larixyl	Larixyl	NNP
cord-006229-7yoilsho	2618	5	acetate	acetate	NN
cord-006229-7yoilsho	2618	6	,	,	,
cord-006229-7yoilsho	2618	7	another	another	DT
cord-006229-7yoilsho	2618	8	component	component	NN
cord-006229-7yoilsho	2618	9	of	of	IN
cord-006229-7yoilsho	2618	10	the	the	DT
cord-006229-7yoilsho	2618	11	resin	resin	NN
cord-006229-7yoilsho	2618	12	showed	show	VBD
cord-006229-7yoilsho	2618	13	an	an	DT
cord-006229-7yoilsho	2618	14	even	even	RB
cord-006229-7yoilsho	2618	15	higher	high	JJR
cord-006229-7yoilsho	2618	16	potency	potency	NN
cord-006229-7yoilsho	2618	17	in	in	IN
cord-006229-7yoilsho	2618	18	TRPC6	TRPC6	NNP
cord-006229-7yoilsho	2618	19	inhibition	inhibition	NN
cord-006229-7yoilsho	2618	20	(	(	-LRB-
cord-006229-7yoilsho	2618	21	IC	IC	NNP
cord-006229-7yoilsho	2618	22	50	50	CD
cord-006229-7yoilsho	2618	23	=	=	SYM
cord-006229-7yoilsho	2618	24	0.26	0.26	CD
cord-006229-7yoilsho	2618	25	µM	µm	CD
cord-006229-7yoilsho	2618	26	)	)	-RRB-
cord-006229-7yoilsho	2618	27	and	and	CC
cord-006229-7yoilsho	2618	28	a	a	DT
cord-006229-7yoilsho	2618	29	12-fold	12-fold	CD
cord-006229-7yoilsho	2618	30	selectivity	selectivity	NN
cord-006229-7yoilsho	2618	31	compared	compare	VBN
cord-006229-7yoilsho	2618	32	to	to	IN
cord-006229-7yoilsho	2618	33	TRPC3	TRPC3	NNS
cord-006229-7yoilsho	2618	34	.	.	.
cord-006229-7yoilsho	2619	1	These	these	DT
cord-006229-7yoilsho	2619	2	findings	finding	NNS
cord-006229-7yoilsho	2619	3	led	lead	VBD
cord-006229-7yoilsho	2619	4	to	to	IN
cord-006229-7yoilsho	2619	5	the	the	DT
cord-006229-7yoilsho	2619	6	idea	idea	NN
cord-006229-7yoilsho	2619	7	that	that	IN
cord-006229-7yoilsho	2619	8	further	further	JJ
cord-006229-7yoilsho	2619	9	modifications	modification	NNS
cord-006229-7yoilsho	2619	10	of	of	IN
cord-006229-7yoilsho	2619	11	the	the	DT
cord-006229-7yoilsho	2619	12	larixol	larixol	NNP
cord-006229-7yoilsho	2619	13	lead	lead	NNP
cord-006229-7yoilsho	2619	14	structure	structure	NN
cord-006229-7yoilsho	2619	15	may	may	MD
cord-006229-7yoilsho	2619	16	reveal	reveal	VB
cord-006229-7yoilsho	2619	17	even	even	RB
cord-006229-7yoilsho	2619	18	more	more	RBR
cord-006229-7yoilsho	2619	19	potent	potent	JJ
cord-006229-7yoilsho	2619	20	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	2619	21	.	.	.
cord-006229-7yoilsho	2620	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	2620	2	,	,	,
cord-006229-7yoilsho	2620	3	changes	change	NNS
cord-006229-7yoilsho	2620	4	in	in	IN
cord-006229-7yoilsho	2620	5	selectivity	selectivity	NN
cord-006229-7yoilsho	2620	6	and	and	CC
cord-006229-7yoilsho	2620	7	efficacy	efficacy	NN
cord-006229-7yoilsho	2620	8	of	of	IN
cord-006229-7yoilsho	2620	9	such	such	JJ
cord-006229-7yoilsho	2620	10	compounds	compound	NNS
cord-006229-7yoilsho	2620	11	may	may	MD
cord-006229-7yoilsho	2620	12	also	also	RB
cord-006229-7yoilsho	2620	13	provide	provide	VB
cord-006229-7yoilsho	2620	14	a	a	DT
cord-006229-7yoilsho	2620	15	deeper	deep	JJR
cord-006229-7yoilsho	2620	16	insight	insight	NN
cord-006229-7yoilsho	2620	17	about	about	IN
cord-006229-7yoilsho	2620	18	relevant	relevant	JJ
cord-006229-7yoilsho	2620	19	structural	structural	JJ
cord-006229-7yoilsho	2620	20	elements	element	NNS
cord-006229-7yoilsho	2620	21	for	for	IN
cord-006229-7yoilsho	2620	22	channel	channel	NN
cord-006229-7yoilsho	2620	23	binding	binding	NN
cord-006229-7yoilsho	2620	24	.	.	.
cord-006229-7yoilsho	2621	1	As	as	IN
cord-006229-7yoilsho	2621	2	larixyl	larixyl	NN
cord-006229-7yoilsho	2621	3	carbamate	carbamate	NNP
cord-006229-7yoilsho	2621	4	was	be	VBD
cord-006229-7yoilsho	2621	5	assumed	assume	VBN
cord-006229-7yoilsho	2621	6	to	to	TO
cord-006229-7yoilsho	2621	7	exhibit	exhibit	VB
cord-006229-7yoilsho	2621	8	a	a	DT
cord-006229-7yoilsho	2621	9	higher	high	JJR
cord-006229-7yoilsho	2621	10	metabolic	metabolic	JJ
cord-006229-7yoilsho	2621	11	stability	stability	NN
cord-006229-7yoilsho	2621	12	as	as	IN
cord-006229-7yoilsho	2621	13	larixyl	larixyl	NN
cord-006229-7yoilsho	2621	14	acetate	acetate	NN
cord-006229-7yoilsho	2621	15	,	,	,
cord-006229-7yoilsho	2621	16	this	this	DT
cord-006229-7yoilsho	2621	17	compound	compound	NN
cord-006229-7yoilsho	2621	18	was	be	VBD
cord-006229-7yoilsho	2621	19	already	already	RB
cord-006229-7yoilsho	2621	20	investigated	investigate	VBN
cord-006229-7yoilsho	2621	21	in	in	IN
cord-006229-7yoilsho	2621	22	previous	previous	JJ
cord-006229-7yoilsho	2621	23	studies	study	NNS
cord-006229-7yoilsho	2621	24	.	.	.
cord-006229-7yoilsho	2622	1	It	-PRON-	PRP
cord-006229-7yoilsho	2622	2	showed	show	VBD
cord-006229-7yoilsho	2622	3	a	a	DT
cord-006229-7yoilsho	2622	4	potent	potent	JJ
cord-006229-7yoilsho	2622	5	and	and	CC
cord-006229-7yoilsho	2622	6	subtype	subtype	NN
cord-006229-7yoilsho	2622	7	-	-	HYPH
cord-006229-7yoilsho	2622	8	selective	selective	JJ
cord-006229-7yoilsho	2622	9	inhibition	inhibition	NN
cord-006229-7yoilsho	2622	10	of	of	IN
cord-006229-7yoilsho	2622	11	TRPC6	TRPC6	NNP
cord-006229-7yoilsho	2622	12	.	.	.
cord-006229-7yoilsho	2623	1	Hence	hence	RB
cord-006229-7yoilsho	2623	2	,	,	,
cord-006229-7yoilsho	2623	3	the	the	DT
cord-006229-7yoilsho	2623	4	development	development	NN
cord-006229-7yoilsho	2623	5	of	of	IN
cord-006229-7yoilsho	2623	6	further	further	JJ
cord-006229-7yoilsho	2623	7	carbamates	carbamates	NNP
cord-006229-7yoilsho	2623	8	was	be	VBD
cord-006229-7yoilsho	2623	9	a	a	DT
cord-006229-7yoilsho	2623	10	priority	priority	NN
cord-006229-7yoilsho	2623	11	objective	objective	NN
cord-006229-7yoilsho	2623	12	.	.	.
cord-006229-7yoilsho	2624	1	As	as	IN
cord-006229-7yoilsho	2624	2	an	an	DT
cord-006229-7yoilsho	2624	3	alternative	alternative	NN
cord-006229-7yoilsho	2624	4	to	to	IN
cord-006229-7yoilsho	2624	5	the	the	DT
cord-006229-7yoilsho	2624	6	use	use	NN
cord-006229-7yoilsho	2624	7	of	of	IN
cord-006229-7yoilsho	2624	8	different	different	JJ
cord-006229-7yoilsho	2624	9	isocyanates	isocyanate	NNS
cord-006229-7yoilsho	2624	10	for	for	IN
cord-006229-7yoilsho	2624	11	the	the	DT
cord-006229-7yoilsho	2624	12	introduction	introduction	NN
cord-006229-7yoilsho	2624	13	of	of	IN
cord-006229-7yoilsho	2624	14	a	a	DT
cord-006229-7yoilsho	2624	15	carbamate	carbamate	NN
cord-006229-7yoilsho	2624	16	function	function	NN
cord-006229-7yoilsho	2624	17	at	at	IN
cord-006229-7yoilsho	2624	18	the	the	DT
cord-006229-7yoilsho	2624	19	C1	C1	NNP
cord-006229-7yoilsho	2624	20	position	position	NN
cord-006229-7yoilsho	2624	21	of	of	IN
cord-006229-7yoilsho	2624	22	the	the	DT
cord-006229-7yoilsho	2624	23	molecule	molecule	NN
cord-006229-7yoilsho	2624	24	we	-PRON-	PRP
cord-006229-7yoilsho	2624	25	found	find	VBD
cord-006229-7yoilsho	2624	26	an	an	DT
cord-006229-7yoilsho	2624	27	elegant	elegant	JJ
cord-006229-7yoilsho	2624	28	way	way	NN
cord-006229-7yoilsho	2624	29	via	via	IN
cord-006229-7yoilsho	2624	30	formation	formation	NN
cord-006229-7yoilsho	2624	31	of	of	IN
cord-006229-7yoilsho	2624	32	an	an	DT
cord-006229-7yoilsho	2624	33	active	active	JJ
cord-006229-7yoilsho	2624	34	ester	ester	NN
cord-006229-7yoilsho	2624	35	with	with	IN
cord-006229-7yoilsho	2624	36	carbonyldiimidazole	carbonyldiimidazole	NNP
cord-006229-7yoilsho	2624	37	.	.	.
cord-006229-7yoilsho	2625	1	This	this	DT
cord-006229-7yoilsho	2625	2	precursor	precursor	NN
cord-006229-7yoilsho	2625	3	allowed	allow	VBD
cord-006229-7yoilsho	2625	4	the	the	DT
cord-006229-7yoilsho	2625	5	design	design	NN
cord-006229-7yoilsho	2625	6	of	of	IN
cord-006229-7yoilsho	2625	7	several	several	JJ
cord-006229-7yoilsho	2625	8	isosteric	isosteric	JJ
cord-006229-7yoilsho	2625	9	compounds	compound	NNS
cord-006229-7yoilsho	2625	10	like	like	IN
cord-006229-7yoilsho	2625	11	larixyl	larixyl	NNP
cord-006229-7yoilsho	2625	12	methylcarbamate	methylcarbamate	NNP
cord-006229-7yoilsho	2625	13	,	,	,
cord-006229-7yoilsho	2625	14	larixyl	larixyl	NNP
cord-006229-7yoilsho	2625	15	hydrazide	hydrazide	NNP
cord-006229-7yoilsho	2625	16	and	and	CC
cord-006229-7yoilsho	2625	17	larixyl	larixyl	NNP
cord-006229-7yoilsho	2625	18	methylcarbonate	methylcarbonate	NNP
cord-006229-7yoilsho	2625	19	,	,	,
cord-006229-7yoilsho	2625	20	which	which	WDT
cord-006229-7yoilsho	2625	21	were	be	VBD
cord-006229-7yoilsho	2625	22	all	all	DT
cord-006229-7yoilsho	2625	23	able	able	JJ
cord-006229-7yoilsho	2625	24	to	to	TO
cord-006229-7yoilsho	2625	25	block	block	VB
cord-006229-7yoilsho	2625	26	TRPC6	TRPC6	NNP
cord-006229-7yoilsho	2625	27	with	with	IN
cord-006229-7yoilsho	2625	28	similarly	similarly	RB
cord-006229-7yoilsho	2625	29	low	low	JJ
cord-006229-7yoilsho	2625	30	IC	IC	NNP
cord-006229-7yoilsho	2625	31	50	50	CD
cord-006229-7yoilsho	2625	32	values	value	NNS
cord-006229-7yoilsho	2625	33	.	.	.
cord-006229-7yoilsho	2626	1	The	the	DT
cord-006229-7yoilsho	2626	2	introduction	introduction	NN
cord-006229-7yoilsho	2626	3	of	of	IN
cord-006229-7yoilsho	2626	4	more	more	RBR
cord-006229-7yoilsho	2626	5	bulky	bulky	JJ
cord-006229-7yoilsho	2626	6	side	side	NN
cord-006229-7yoilsho	2626	7	chains	chain	NNS
cord-006229-7yoilsho	2626	8	appeared	appear	VBD
cord-006229-7yoilsho	2626	9	to	to	TO
cord-006229-7yoilsho	2626	10	diminish	diminish	VB
cord-006229-7yoilsho	2626	11	the	the	DT
cord-006229-7yoilsho	2626	12	bioactivity	bioactivity	NN
cord-006229-7yoilsho	2626	13	of	of	IN
cord-006229-7yoilsho	2626	14	the	the	DT
cord-006229-7yoilsho	2626	15	compounds	compound	NNS
cord-006229-7yoilsho	2626	16	,	,	,
cord-006229-7yoilsho	2626	17	the	the	DT
cord-006229-7yoilsho	2626	18	stereochemistry	stereochemistry	NN
cord-006229-7yoilsho	2626	19	at	at	IN
cord-006229-7yoilsho	2626	20	the	the	DT
cord-006229-7yoilsho	2626	21	C1	C1	NNP
cord-006229-7yoilsho	2626	22	position	position	NN
cord-006229-7yoilsho	2626	23	,	,	,
cord-006229-7yoilsho	2626	24	however	however	RB
cord-006229-7yoilsho	2626	25	,	,	,
cord-006229-7yoilsho	2626	26	seems	seem	VBZ
cord-006229-7yoilsho	2626	27	to	to	TO
cord-006229-7yoilsho	2626	28	play	play	VB
cord-006229-7yoilsho	2626	29	no	no	DT
cord-006229-7yoilsho	2626	30	important	important	JJ
cord-006229-7yoilsho	2626	31	role	role	NN
cord-006229-7yoilsho	2626	32	for	for	IN
cord-006229-7yoilsho	2626	33	the	the	DT
cord-006229-7yoilsho	2626	34	inhibition	inhibition	NN
cord-006229-7yoilsho	2626	35	of	of	IN
cord-006229-7yoilsho	2626	36	TRPC6	TRPC6	NNP
cord-006229-7yoilsho	2626	37	currents	current	NNS
cord-006229-7yoilsho	2626	38	.	.	.
cord-006229-7yoilsho	2627	1	Larixyl	Larixyl	NNP
cord-006229-7yoilsho	2627	2	methylcarbamate	methylcarbamate	NNP
cord-006229-7yoilsho	2627	3	lead	lead	NN
cord-006229-7yoilsho	2627	4	to	to	IN
cord-006229-7yoilsho	2627	5	TRPC6	TRPC6	NNP
cord-006229-7yoilsho	2627	6	inhibition	inhibition	NN
cord-006229-7yoilsho	2627	7	with	with	IN
cord-006229-7yoilsho	2627	8	an	an	DT
cord-006229-7yoilsho	2627	9	IC	IC	NNP
cord-006229-7yoilsho	2627	10	50	50	CD
cord-006229-7yoilsho	2627	11	value	value	NN
cord-006229-7yoilsho	2627	12	of	of	IN
cord-006229-7yoilsho	2627	13	0.15	0.15	CD
cord-006229-7yoilsho	2627	14	±	±	CD
cord-006229-7yoilsho	2627	15	0.06	0.06	CD
cord-006229-7yoilsho	2627	16	µM.	µM.	NNP
cord-006229-7yoilsho	2628	1	Compared	compare	VBN
cord-006229-7yoilsho	2628	2	to	to	IN
cord-006229-7yoilsho	2628	3	larixyl	larixyl	NN
cord-006229-7yoilsho	2628	4	carbamate	carbamate	NNP
cord-006229-7yoilsho	2628	5	and	and	CC
cord-006229-7yoilsho	2628	6	larixyl	larixyl	NNP
cord-006229-7yoilsho	2628	7	methylcarbonate	methylcarbonate	NNP
cord-006229-7yoilsho	2628	8	,	,	,
cord-006229-7yoilsho	2628	9	which	which	WDT
cord-006229-7yoilsho	2628	10	are	be	VBP
cord-006229-7yoilsho	2628	11	also	also	RB
cord-006229-7yoilsho	2628	12	very	very	RB
cord-006229-7yoilsho	2628	13	potent	potent	JJ
cord-006229-7yoilsho	2628	14	blockers	blocker	NNS
cord-006229-7yoilsho	2628	15	of	of	IN
cord-006229-7yoilsho	2628	16	TRPC6	TRPC6	NNP
cord-006229-7yoilsho	2628	17	,	,	,
cord-006229-7yoilsho	2628	18	this	this	DT
cord-006229-7yoilsho	2628	19	compound	compound	NN
cord-006229-7yoilsho	2628	20	bears	bear	VBZ
cord-006229-7yoilsho	2628	21	the	the	DT
cord-006229-7yoilsho	2628	22	benefit	benefit	NN
cord-006229-7yoilsho	2628	23	of	of	IN
cord-006229-7yoilsho	2628	24	high	high	JJ
cord-006229-7yoilsho	2628	25	subtype	subtype	NN
cord-006229-7yoilsho	2628	26	selectivity	selectivity	NN
cord-006229-7yoilsho	2628	27	towards	towards	IN
cord-006229-7yoilsho	2628	28	TRPC3	TRPC3	NNS
cord-006229-7yoilsho	2628	29	.	.	.
cord-006229-7yoilsho	2629	1	Even	even	RB
cord-006229-7yoilsho	2629	2	with	with	IN
cord-006229-7yoilsho	2629	3	concentrations	concentration	NNS
cord-006229-7yoilsho	2629	4	up	up	IN
cord-006229-7yoilsho	2629	5	to	to	TO
cord-006229-7yoilsho	2629	6	50	50	CD
cord-006229-7yoilsho	2629	7	µM	µM	NFP
cord-006229-7yoilsho	2629	8	of	of	IN
cord-006229-7yoilsho	2629	9	larixyl	larixyl	NNP
cord-006229-7yoilsho	2629	10	methylcarbamate	methylcarbamate	NNP
cord-006229-7yoilsho	2629	11	,	,	,
cord-006229-7yoilsho	2629	12	no	no	DT
cord-006229-7yoilsho	2629	13	complete	complete	JJ
cord-006229-7yoilsho	2629	14	inhibition	inhibition	NN
cord-006229-7yoilsho	2629	15	of	of	IN
cord-006229-7yoilsho	2629	16	the	the	DT
cord-006229-7yoilsho	2629	17	Ca	Ca	NNP
cord-006229-7yoilsho	2629	18	2	2	CD
cord-006229-7yoilsho	2629	19	+	+	CC
cord-006229-7yoilsho	2629	20	influx	influx	NN
cord-006229-7yoilsho	2629	21	via	via	IN
cord-006229-7yoilsho	2629	22	TRPC3	TRPC3	NNS
cord-006229-7yoilsho	2629	23	channels	channel	NNS
cord-006229-7yoilsho	2629	24	could	could	MD
cord-006229-7yoilsho	2629	25	be	be	VB
cord-006229-7yoilsho	2629	26	achieved	achieve	VBN
cord-006229-7yoilsho	2629	27	.	.	.
cord-006229-7yoilsho	2630	1	This	this	DT
cord-006229-7yoilsho	2630	2	fact	fact	NN
cord-006229-7yoilsho	2630	3	distinguishes	distinguish	VBZ
cord-006229-7yoilsho	2630	4	this	this	DT
cord-006229-7yoilsho	2630	5	larixol	larixol	NN
cord-006229-7yoilsho	2630	6	derivative	derivative	JJ
cord-006229-7yoilsho	2630	7	as	as	IN
cord-006229-7yoilsho	2630	8	a	a	DT
cord-006229-7yoilsho	2630	9	very	very	RB
cord-006229-7yoilsho	2630	10	promising	promising	JJ
cord-006229-7yoilsho	2630	11	compound	compound	NN
cord-006229-7yoilsho	2630	12	for	for	IN
cord-006229-7yoilsho	2630	13	further	further	JJ
cord-006229-7yoilsho	2630	14	studies	study	NNS
cord-006229-7yoilsho	2630	15	of	of	IN
cord-006229-7yoilsho	2630	16	TRPC6	TRPC6	NNP
cord-006229-7yoilsho	2630	17	in	in	IN
cord-006229-7yoilsho	2630	18	health	health	NN
cord-006229-7yoilsho	2630	19	and	and	CC
cord-006229-7yoilsho	2630	20	disease	disease	NN
cord-006229-7yoilsho	2630	21	.	.	.
cord-006229-7yoilsho	2631	1	Poisoning	poisoning	NN
cord-006229-7yoilsho	2631	2	by	by	IN
cord-006229-7yoilsho	2631	3	organophosphorus	organophosphorus	JJ
cord-006229-7yoilsho	2631	4	compounds	compound	NNS
cord-006229-7yoilsho	2631	5	(	(	-LRB-
cord-006229-7yoilsho	2631	6	OPC	OPC	NNP
cord-006229-7yoilsho	2631	7	)	)	-RRB-
cord-006229-7yoilsho	2631	8	including	include	VBG
cord-006229-7yoilsho	2631	9	pesticides	pesticide	NNS
cord-006229-7yoilsho	2631	10	and	and	CC
cord-006229-7yoilsho	2631	11	highly	highly	RB
cord-006229-7yoilsho	2631	12	toxic	toxic	JJ
cord-006229-7yoilsho	2631	13	nerve	nerve	NN
cord-006229-7yoilsho	2631	14	agents	agent	NNS
cord-006229-7yoilsho	2631	15	is	be	VBZ
cord-006229-7yoilsho	2631	16	based	base	VBN
cord-006229-7yoilsho	2631	17	on	on	IN
cord-006229-7yoilsho	2631	18	irreversible	irreversible	JJ
cord-006229-7yoilsho	2631	19	inhibition	inhibition	NN
cord-006229-7yoilsho	2631	20	of	of	IN
cord-006229-7yoilsho	2631	21	acetylcholinesterase	acetylcholinesterase	NN
cord-006229-7yoilsho	2631	22	(	(	-LRB-
cord-006229-7yoilsho	2631	23	AChE	ache	NN
cord-006229-7yoilsho	2631	24	)	)	-RRB-
cord-006229-7yoilsho	2631	25	resulting	result	VBG
cord-006229-7yoilsho	2631	26	in	in	IN
cord-006229-7yoilsho	2631	27	an	an	DT
cord-006229-7yoilsho	2631	28	excess	excess	NN
cord-006229-7yoilsho	2631	29	of	of	IN
cord-006229-7yoilsho	2631	30	acetylcholine	acetylcholine	NN
cord-006229-7yoilsho	2631	31	causing	cause	VBG
cord-006229-7yoilsho	2631	32	accumulation	accumulation	NN
cord-006229-7yoilsho	2631	33	.	.	.
cord-006229-7yoilsho	2632	1	The	the	DT
cord-006229-7yoilsho	2632	2	subsequent	subsequent	JJ
cord-006229-7yoilsho	2632	3	overstimulation	overstimulation	NN
cord-006229-7yoilsho	2632	4	at	at	IN
cord-006229-7yoilsho	2632	5	nicotinic	nicotinic	JJ
cord-006229-7yoilsho	2632	6	and	and	CC
cord-006229-7yoilsho	2632	7	muscarinic	muscarinic	JJ
cord-006229-7yoilsho	2632	8	receptors	receptor	NNS
cord-006229-7yoilsho	2632	9	finally	finally	RB
cord-006229-7yoilsho	2632	10	leads	lead	VBZ
cord-006229-7yoilsho	2632	11	to	to	IN
cord-006229-7yoilsho	2632	12	respiratory	respiratory	JJ
cord-006229-7yoilsho	2632	13	arrest	arrest	NN
cord-006229-7yoilsho	2632	14	due	due	IN
cord-006229-7yoilsho	2632	15	to	to	IN
cord-006229-7yoilsho	2632	16	paralysis	paralysis	NN
cord-006229-7yoilsho	2632	17	of	of	IN
cord-006229-7yoilsho	2632	18	the	the	DT
cord-006229-7yoilsho	2632	19	respiratory	respiratory	JJ
cord-006229-7yoilsho	2632	20	muscles	muscle	NNS
cord-006229-7yoilsho	2632	21	.	.	.
cord-006229-7yoilsho	2633	1	Therapy	therapy	NN
cord-006229-7yoilsho	2633	2	focuses	focus	VBZ
cord-006229-7yoilsho	2633	3	on	on	IN
cord-006229-7yoilsho	2633	4	competitive	competitive	JJ
cord-006229-7yoilsho	2633	5	antagonism	antagonism	NN
cord-006229-7yoilsho	2633	6	at	at	IN
cord-006229-7yoilsho	2633	7	muscarinic	muscarinic	JJ
cord-006229-7yoilsho	2633	8	acetylcholine	acetylcholine	NN
cord-006229-7yoilsho	2633	9	receptors	receptor	NNS
cord-006229-7yoilsho	2633	10	and	and	CC
cord-006229-7yoilsho	2633	11	reactivation	reactivation	NN
cord-006229-7yoilsho	2633	12	of	of	IN
cord-006229-7yoilsho	2633	13	inhibited	inhibited	JJ
cord-006229-7yoilsho	2633	14	AChE	ache	NN
cord-006229-7yoilsho	2633	15	by	by	IN
cord-006229-7yoilsho	2633	16	bisquarternary	bisquarternary	NNP
cord-006229-7yoilsho	2633	17	pyridinium	pyridinium	NNP
cord-006229-7yoilsho	2633	18	oximes	oximes	NNP
cord-006229-7yoilsho	2633	19	.	.	.
cord-006229-7yoilsho	2634	1	Thereby	thereby	RB
cord-006229-7yoilsho	2634	2	,	,	,
cord-006229-7yoilsho	2634	3	nicotinic	nicotinic	JJ
cord-006229-7yoilsho	2634	4	malfunction	malfunction	NN
cord-006229-7yoilsho	2634	5	is	be	VBZ
cord-006229-7yoilsho	2634	6	not	not	RB
cord-006229-7yoilsho	2634	7	directly	directly	RB
cord-006229-7yoilsho	2634	8	approached	approach	VBN
cord-006229-7yoilsho	2634	9	.	.	.
cord-006229-7yoilsho	2635	1	For	for	IN
cord-006229-7yoilsho	2635	2	that	that	DT
cord-006229-7yoilsho	2635	3	reason	reason	NN
cord-006229-7yoilsho	2635	4	,	,	,
cord-006229-7yoilsho	2635	5	an	an	DT
cord-006229-7yoilsho	2635	6	alternative	alternative	JJ
cord-006229-7yoilsho	2635	7	strategy	strategy	NN
cord-006229-7yoilsho	2635	8	appears	appear	VBZ
cord-006229-7yoilsho	2635	9	rational	rational	JJ
cord-006229-7yoilsho	2635	10	using	use	VBG
cord-006229-7yoilsho	2635	11	nicotinic	nicotinic	JJ
cord-006229-7yoilsho	2635	12	acetylcholine	acetylcholine	NN
cord-006229-7yoilsho	2635	13	receptor	receptor	NN
cord-006229-7yoilsho	2635	14	(	(	-LRB-
cord-006229-7yoilsho	2635	15	nAChR	nAChR	NNP
cord-006229-7yoilsho	2635	16	)	)	-RRB-
cord-006229-7yoilsho	2635	17	active	active	JJ
cord-006229-7yoilsho	2635	18	substances	substance	NNS
cord-006229-7yoilsho	2635	19	to	to	TO
cord-006229-7yoilsho	2635	20	counteract	counteract	VB
cord-006229-7yoilsho	2635	21	the	the	DT
cord-006229-7yoilsho	2635	22	effects	effect	NNS
cord-006229-7yoilsho	2635	23	of	of	IN
cord-006229-7yoilsho	2635	24	accumulated	accumulate	VBN
cord-006229-7yoilsho	2635	25	acetylcholine	acetylcholine	NN
cord-006229-7yoilsho	2635	26	and	and	CC
cord-006229-7yoilsho	2635	27	thus	thus	RB
cord-006229-7yoilsho	2635	28	to	to	TO
cord-006229-7yoilsho	2635	29	restore	restore	VB
cord-006229-7yoilsho	2635	30	the	the	DT
cord-006229-7yoilsho	2635	31	loss	loss	NN
cord-006229-7yoilsho	2635	32	of	of	IN
cord-006229-7yoilsho	2635	33	function	function	NN
cord-006229-7yoilsho	2635	34	of	of	IN
cord-006229-7yoilsho	2635	35	nAChRs	nAChRs	NNP
cord-006229-7yoilsho	2635	36	.	.	.
cord-006229-7yoilsho	2636	1	Different	different	JJ
cord-006229-7yoilsho	2636	2	bispyridinium	bispyridinium	NN
cord-006229-7yoilsho	2636	3	-	-	HYPH
cord-006229-7yoilsho	2636	4	non	non	JJ
cord-006229-7yoilsho	2636	5	-	-	JJ
cord-006229-7yoilsho	2636	6	oxime	oxime	JJ
cord-006229-7yoilsho	2636	7	-	-	HYPH
cord-006229-7yoilsho	2636	8	compounds	compound	NNS
cord-006229-7yoilsho	2636	9	(	(	-LRB-
cord-006229-7yoilsho	2636	10	BPs	bp	NNS
cord-006229-7yoilsho	2636	11	)	)	-RRB-
cord-006229-7yoilsho	2636	12	have	have	VBP
cord-006229-7yoilsho	2636	13	been	be	VBN
cord-006229-7yoilsho	2636	14	demonstrated	demonstrate	VBN
cord-006229-7yoilsho	2636	15	to	to	TO
cord-006229-7yoilsho	2636	16	be	be	VB
cord-006229-7yoilsho	2636	17	able	able	JJ
cord-006229-7yoilsho	2636	18	to	to	TO
cord-006229-7yoilsho	2636	19	serve	serve	VB
cord-006229-7yoilsho	2636	20	as	as	IN
cord-006229-7yoilsho	2636	21	target	target	NN
cord-006229-7yoilsho	2636	22	structures	structure	NNS
cord-006229-7yoilsho	2636	23	for	for	IN
cord-006229-7yoilsho	2636	24	the	the	DT
cord-006229-7yoilsho	2636	25	identification	identification	NN
cord-006229-7yoilsho	2636	26	of	of	IN
cord-006229-7yoilsho	2636	27	new	new	JJ
cord-006229-7yoilsho	2636	28	positive	positive	JJ
cord-006229-7yoilsho	2636	29	allosteric	allosteric	JJ
cord-006229-7yoilsho	2636	30	modulators	modulator	NNS
cord-006229-7yoilsho	2636	31	of	of	IN
cord-006229-7yoilsho	2636	32	nicotinic	nicotinic	JJ
cord-006229-7yoilsho	2636	33	receptors	receptor	NNS
cord-006229-7yoilsho	2636	34	.	.	.
cord-006229-7yoilsho	2637	1	Unlike	unlike	IN
cord-006229-7yoilsho	2637	2	nicotinic	nicotinic	JJ
cord-006229-7yoilsho	2637	3	agonists	agonist	NNS
cord-006229-7yoilsho	2637	4	,	,	,
cord-006229-7yoilsho	2637	5	positive	positive	JJ
cord-006229-7yoilsho	2637	6	allosteric	allosteric	JJ
cord-006229-7yoilsho	2637	7	modulators	modulator	NNS
cord-006229-7yoilsho	2637	8	can	can	MD
cord-006229-7yoilsho	2637	9	reinforce	reinforce	VB
cord-006229-7yoilsho	2637	10	the	the	DT
cord-006229-7yoilsho	2637	11	endogenous	endogenous	JJ
cord-006229-7yoilsho	2637	12	cholinergic	cholinergic	JJ
cord-006229-7yoilsho	2637	13	neurotransmission	neurotransmission	NN
cord-006229-7yoilsho	2637	14	despite	despite	IN
cord-006229-7yoilsho	2637	15	of	of	IN
cord-006229-7yoilsho	2637	16	acetylcholine	acetylcholine	NN
cord-006229-7yoilsho	2637	17	accumulation	accumulation	NN
cord-006229-7yoilsho	2637	18	in	in	IN
cord-006229-7yoilsho	2637	19	the	the	DT
cord-006229-7yoilsho	2637	20	synaptic	synaptic	JJ
cord-006229-7yoilsho	2637	21	cleft	cleft	NN
cord-006229-7yoilsho	2637	22	.	.	.
cord-006229-7yoilsho	2638	1	To	to	IN
cord-006229-7yoilsho	2638	2	this	this	DT
cord-006229-7yoilsho	2638	3	end	end	NN
cord-006229-7yoilsho	2638	4	,	,	,
cord-006229-7yoilsho	2638	5	the	the	DT
cord-006229-7yoilsho	2638	6	following	follow	VBG
cord-006229-7yoilsho	2638	7	electrophysiological	electrophysiological	JJ
cord-006229-7yoilsho	2638	8	in	in	IN
cord-006229-7yoilsho	2638	9	vitro	vitro	FW
cord-006229-7yoilsho	2638	10	study	study	NN
cord-006229-7yoilsho	2638	11	investigated	investigate	VBD
cord-006229-7yoilsho	2638	12	the	the	DT
cord-006229-7yoilsho	2638	13	effect	effect	NN
cord-006229-7yoilsho	2638	14	of	of	IN
cord-006229-7yoilsho	2638	15	twelve	twelve	CD
cord-006229-7yoilsho	2638	16	diversely	diversely	RB
cord-006229-7yoilsho	2638	17	substituted	substitute	VBD
cord-006229-7yoilsho	2638	18	BPs	bp	NNS
cord-006229-7yoilsho	2638	19	on	on	IN
cord-006229-7yoilsho	2638	20	human	human	NN
cord-006229-7yoilsho	2638	21	α7	α7	NNP
cord-006229-7yoilsho	2638	22	nAChR	nAChR	NNP
cord-006229-7yoilsho	2638	23	using	use	VBG
cord-006229-7yoilsho	2638	24	whole	whole	JJ
cord-006229-7yoilsho	2638	25	-	-	HYPH
cord-006229-7yoilsho	2638	26	cell	cell	NN
cord-006229-7yoilsho	2638	27	patch	patch	NN
cord-006229-7yoilsho	2638	28	clamping	clamp	VBG
cord-006229-7yoilsho	2638	29	under	under	IN
cord-006229-7yoilsho	2638	30	voltage	voltage	NN
cord-006229-7yoilsho	2638	31	-	-	HYPH
cord-006229-7yoilsho	2638	32	clamping	clamp	VBG
cord-006229-7yoilsho	2638	33	conditions	condition	NNS
cord-006229-7yoilsho	2638	34	(	(	-LRB-
cord-006229-7yoilsho	2638	35	-70	-70	NNP
cord-006229-7yoilsho	2638	36	mV	mV	NNP
cord-006229-7yoilsho	2638	37	)	)	-RRB-
cord-006229-7yoilsho	2638	38	performed	perform	VBN
cord-006229-7yoilsho	2638	39	with	with	IN
cord-006229-7yoilsho	2638	40	planar	planar	JJ
cord-006229-7yoilsho	2638	41	electrodes	electrode	NNS
cord-006229-7yoilsho	2638	42	in	in	IN
cord-006229-7yoilsho	2638	43	an	an	DT
cord-006229-7yoilsho	2638	44	automatic	automatic	JJ
cord-006229-7yoilsho	2638	45	system	system	NN
cord-006229-7yoilsho	2638	46	(	(	-LRB-
cord-006229-7yoilsho	2638	47	Nanion	Nanion	NNP
cord-006229-7yoilsho	2638	48	Technologies	Technologies	NNPS
cord-006229-7yoilsho	2638	49	GmbH	GmbH	NNP
cord-006229-7yoilsho	2638	50	,	,	,
cord-006229-7yoilsho	2638	51	Munich	Munich	NNP
cord-006229-7yoilsho	2638	52	)	)	-RRB-
cord-006229-7yoilsho	2638	53	.	.	.
cord-006229-7yoilsho	2639	1	Cholinergic	cholinergic	JJ
cord-006229-7yoilsho	2639	2	currents	current	NNS
cord-006229-7yoilsho	2639	3	of	of	IN
cord-006229-7yoilsho	2639	4	hα7	hα7	NN
cord-006229-7yoilsho	2639	5	nAChR	nAChR	NNP
cord-006229-7yoilsho	2639	6	that	that	WDT
cord-006229-7yoilsho	2639	7	have	have	VBP
cord-006229-7yoilsho	2639	8	been	be	VBN
cord-006229-7yoilsho	2639	9	expressed	express	VBN
cord-006229-7yoilsho	2639	10	in	in	IN
cord-006229-7yoilsho	2639	11	stably	stably	RB
cord-006229-7yoilsho	2639	12	transfected	transfecte	VBN
cord-006229-7yoilsho	2639	13	CHO	CHO	NNP
cord-006229-7yoilsho	2639	14	cells	cell	NNS
cord-006229-7yoilsho	2639	15	were	be	VBD
cord-006229-7yoilsho	2639	16	activated	activate	VBN
cord-006229-7yoilsho	2639	17	by	by	IN
cord-006229-7yoilsho	2639	18	the	the	DT
cord-006229-7yoilsho	2639	19	agonist	agonist	NN
cord-006229-7yoilsho	2639	20	nicotine	nicotine	NN
cord-006229-7yoilsho	2639	21	.	.	.
cord-006229-7yoilsho	2640	1	Measurements	measurement	NNS
cord-006229-7yoilsho	2640	2	of	of	IN
cord-006229-7yoilsho	2640	3	the	the	DT
cord-006229-7yoilsho	2640	4	effect	effect	NN
cord-006229-7yoilsho	2640	5	of	of	IN
cord-006229-7yoilsho	2640	6	various	various	JJ
cord-006229-7yoilsho	2640	7	BPs	bps	JJ
cord-006229-7yoilsho	2640	8	concentrations	concentration	NNS
cord-006229-7yoilsho	2640	9	in	in	IN
cord-006229-7yoilsho	2640	10	the	the	DT
cord-006229-7yoilsho	2640	11	presence	presence	NN
cord-006229-7yoilsho	2640	12	of	of	IN
cord-006229-7yoilsho	2640	13	nicotine	nicotine	NN
cord-006229-7yoilsho	2640	14	were	be	VBD
cord-006229-7yoilsho	2640	15	performed	perform	VBN
cord-006229-7yoilsho	2640	16	to	to	TO
cord-006229-7yoilsho	2640	17	establish	establish	VB
cord-006229-7yoilsho	2640	18	concentration	concentration	NN
cord-006229-7yoilsho	2640	19	-	-	HYPH
cord-006229-7yoilsho	2640	20	response	response	NN
cord-006229-7yoilsho	2640	21	relations	relation	NNS
cord-006229-7yoilsho	2640	22	.	.	.
cord-006229-7yoilsho	2641	1	Cholinergic	cholinergic	JJ
cord-006229-7yoilsho	2641	2	inward	inward	JJ
cord-006229-7yoilsho	2641	3	currents	current	NNS
cord-006229-7yoilsho	2641	4	were	be	VBD
cord-006229-7yoilsho	2641	5	generated	generate	VBN
cord-006229-7yoilsho	2641	6	by	by	IN
cord-006229-7yoilsho	2641	7	human	human	JJ
cord-006229-7yoilsho	2641	8	α7	α7	NNP
cord-006229-7yoilsho	2641	9	nAChRs	nachrs	NN
cord-006229-7yoilsho	2641	10	in	in	IN
cord-006229-7yoilsho	2641	11	response	response	NN
cord-006229-7yoilsho	2641	12	to	to	IN
cord-006229-7yoilsho	2641	13	low	low	JJ
cord-006229-7yoilsho	2641	14	nicotine	nicotine	NN
cord-006229-7yoilsho	2641	15	concentrations	concentration	NNS
cord-006229-7yoilsho	2641	16	.	.	.
cord-006229-7yoilsho	2642	1	At	at	IN
cord-006229-7yoilsho	2642	2	high	high	JJ
cord-006229-7yoilsho	2642	3	concentrations	concentration	NNS
cord-006229-7yoilsho	2642	4	of	of	IN
cord-006229-7yoilsho	2642	5	the	the	DT
cord-006229-7yoilsho	2642	6	drug	drug	NN
cord-006229-7yoilsho	2642	7	the	the	DT
cord-006229-7yoilsho	2642	8	currents	current	NNS
cord-006229-7yoilsho	2642	9	were	be	VBD
cord-006229-7yoilsho	2642	10	decayed	decay	VBN
cord-006229-7yoilsho	2642	11	reflecting	reflect	VBG
cord-006229-7yoilsho	2642	12	both	both	DT
cord-006229-7yoilsho	2642	13	,	,	,
cord-006229-7yoilsho	2642	14	desensitization	desensitization	NN
cord-006229-7yoilsho	2642	15	of	of	IN
cord-006229-7yoilsho	2642	16	the	the	DT
cord-006229-7yoilsho	2642	17	receptors	receptor	NNS
cord-006229-7yoilsho	2642	18	and	and	CC
cord-006229-7yoilsho	2642	19	presumably	presumably	RB
cord-006229-7yoilsho	2642	20	block	block	VBP
cord-006229-7yoilsho	2642	21	of	of	IN
cord-006229-7yoilsho	2642	22	the	the	DT
cord-006229-7yoilsho	2642	23	open	open	JJ
cord-006229-7yoilsho	2642	24	channel	channel	NN
cord-006229-7yoilsho	2642	25	by	by	IN
cord-006229-7yoilsho	2642	26	high	high	JJ
cord-006229-7yoilsho	2642	27	agonist	agonist	NN
cord-006229-7yoilsho	2642	28	concentrations	concentration	NNS
cord-006229-7yoilsho	2642	29	.	.	.
cord-006229-7yoilsho	2643	1	Four	four	CD
cord-006229-7yoilsho	2643	2	out	out	IN
cord-006229-7yoilsho	2643	3	of	of	IN
cord-006229-7yoilsho	2643	4	twelve	twelve	CD
cord-006229-7yoilsho	2643	5	BPs	bp	NNS
cord-006229-7yoilsho	2643	6	co	co	NN
cord-006229-7yoilsho	2643	7	-	-	VBN
cord-006229-7yoilsho	2643	8	applicated	applicate	VBN
cord-006229-7yoilsho	2643	9	with	with	IN
cord-006229-7yoilsho	2643	10	nicotine	nicotine	NN
cord-006229-7yoilsho	2643	11	showed	show	VBD
cord-006229-7yoilsho	2643	12	a	a	DT
cord-006229-7yoilsho	2643	13	concentration	concentration	NN
cord-006229-7yoilsho	2643	14	-	-	HYPH
cord-006229-7yoilsho	2643	15	dependent	dependent	JJ
cord-006229-7yoilsho	2643	16	enhancement	enhancement	NN
cord-006229-7yoilsho	2643	17	of	of	IN
cord-006229-7yoilsho	2643	18	peak	peak	JJ
cord-006229-7yoilsho	2643	19	agonist	agonist	NN
cord-006229-7yoilsho	2643	20	-	-	HYPH
cord-006229-7yoilsho	2643	21	evoked	evoke	VBN
cord-006229-7yoilsho	2643	22	currents	current	NNS
cord-006229-7yoilsho	2643	23	and	and	CC
cord-006229-7yoilsho	2643	24	,	,	,
cord-006229-7yoilsho	2643	25	most	most	RBS
cord-006229-7yoilsho	2643	26	pronounced	pronounce	VBN
cord-006229-7yoilsho	2643	27	,	,	,
cord-006229-7yoilsho	2643	28	4-tert	4-tert	CD
cord-006229-7yoilsho	2643	29	-	-	HYPH
cord-006229-7yoilsho	2643	30	butyl	butyl	NN
cord-006229-7yoilsho	2643	31	-	-	HYPH
cord-006229-7yoilsho	2643	32	substitued	substitue	VBN
cord-006229-7yoilsho	2643	33	-	-	HYPH
cord-006229-7yoilsho	2643	34	BP	BP	NNP
cord-006229-7yoilsho	2643	35	,	,	,
cord-006229-7yoilsho	2643	36	also	also	RB
cord-006229-7yoilsho	2643	37	demonstrated	demonstrate	VBD
cord-006229-7yoilsho	2643	38	a	a	DT
cord-006229-7yoilsho	2643	39	marked	marked	JJ
cord-006229-7yoilsho	2643	40	elongation	elongation	NN
cord-006229-7yoilsho	2643	41	of	of	IN
cord-006229-7yoilsho	2643	42	the	the	DT
cord-006229-7yoilsho	2643	43	evoked	evoke	VBN
cord-006229-7yoilsho	2643	44	response	response	NN
cord-006229-7yoilsho	2643	45	.	.	.
cord-006229-7yoilsho	2644	1	This	this	DT
cord-006229-7yoilsho	2644	2	suggests	suggest	VBZ
cord-006229-7yoilsho	2644	3	a	a	DT
cord-006229-7yoilsho	2644	4	positive	positive	JJ
cord-006229-7yoilsho	2644	5	allosteric	allosteric	JJ
cord-006229-7yoilsho	2644	6	effect	effect	NN
cord-006229-7yoilsho	2644	7	of	of	IN
cord-006229-7yoilsho	2644	8	these	these	DT
cord-006229-7yoilsho	2644	9	compounds	compound	NNS
cord-006229-7yoilsho	2644	10	on	on	IN
cord-006229-7yoilsho	2644	11	the	the	DT
cord-006229-7yoilsho	2644	12	nicotinic	nicotinic	JJ
cord-006229-7yoilsho	2644	13	receptor	receptor	NN
cord-006229-7yoilsho	2644	14	.	.	.
cord-006229-7yoilsho	2645	1	However	however	RB
cord-006229-7yoilsho	2645	2	,	,	,
cord-006229-7yoilsho	2645	3	at	at	IN
cord-006229-7yoilsho	2645	4	high	high	JJ
cord-006229-7yoilsho	2645	5	BP	BP	NNP
cord-006229-7yoilsho	2645	6	concentrations	concentration	NNS
cord-006229-7yoilsho	2645	7	in	in	IN
cord-006229-7yoilsho	2645	8	the	the	DT
cord-006229-7yoilsho	2645	9	presence	presence	NN
cord-006229-7yoilsho	2645	10	of	of	IN
cord-006229-7yoilsho	2645	11	agonist	agonist	NN
cord-006229-7yoilsho	2645	12	,	,	,
cord-006229-7yoilsho	2645	13	responses	response	NNS
cord-006229-7yoilsho	2645	14	were	be	VBD
cord-006229-7yoilsho	2645	15	decayed	decay	VBN
cord-006229-7yoilsho	2645	16	significantly	significantly	RB
cord-006229-7yoilsho	2645	17	,	,	,
cord-006229-7yoilsho	2645	18	presumably	presumably	RB
cord-006229-7yoilsho	2645	19	resulting	result	VBG
cord-006229-7yoilsho	2645	20	from	from	IN
cord-006229-7yoilsho	2645	21	an	an	DT
cord-006229-7yoilsho	2645	22	open	open	JJ
cord-006229-7yoilsho	2645	23	channel	channel	NN
cord-006229-7yoilsho	2645	24	block	block	NN
cord-006229-7yoilsho	2645	25	induced	induce	VBN
cord-006229-7yoilsho	2645	26	by	by	IN
cord-006229-7yoilsho	2645	27	BPs	bp	NNS
cord-006229-7yoilsho	2645	28	.	.	.
cord-006229-7yoilsho	2646	1	Hence	hence	RB
cord-006229-7yoilsho	2646	2	,	,	,
cord-006229-7yoilsho	2646	3	further	further	JJ
cord-006229-7yoilsho	2646	4	compounds	compound	NNS
cord-006229-7yoilsho	2646	5	have	have	VBP
cord-006229-7yoilsho	2646	6	to	to	TO
cord-006229-7yoilsho	2646	7	be	be	VB
cord-006229-7yoilsho	2646	8	synthesized	synthesize	VBN
cord-006229-7yoilsho	2646	9	to	to	TO
cord-006229-7yoilsho	2646	10	identify	identify	VB
cord-006229-7yoilsho	2646	11	promising	promising	JJ
cord-006229-7yoilsho	2646	12	candidate	candidate	NN
cord-006229-7yoilsho	2646	13	compounds	compound	NNS
cord-006229-7yoilsho	2646	14	for	for	IN
cord-006229-7yoilsho	2646	15	improvement	improvement	NN
cord-006229-7yoilsho	2646	16	of	of	IN
cord-006229-7yoilsho	2646	17	effective	effective	JJ
cord-006229-7yoilsho	2646	18	therapy	therapy	NN
cord-006229-7yoilsho	2646	19	against	against	IN
cord-006229-7yoilsho	2646	20	nerve	nerve	NN
cord-006229-7yoilsho	2646	21	agent	agent	NN
cord-006229-7yoilsho	2646	22	poisoning	poisoning	NN
cord-006229-7yoilsho	2646	23	.	.	.
cord-006229-7yoilsho	2647	1	The	the	DT
cord-006229-7yoilsho	2647	2	transient	transient	JJ
cord-006229-7yoilsho	2647	3	receptor	receptor	NN
cord-006229-7yoilsho	2647	4	potential	potential	JJ
cord-006229-7yoilsho	2647	5	channels	channel	NNS
cord-006229-7yoilsho	2647	6	(	(	-LRB-
cord-006229-7yoilsho	2647	7	TRP	TRP	NNP
cord-006229-7yoilsho	2647	8	)	)	-RRB-
cord-006229-7yoilsho	2647	9	are	be	VBP
cord-006229-7yoilsho	2647	10	a	a	DT
cord-006229-7yoilsho	2647	11	family	family	NN
cord-006229-7yoilsho	2647	12	of	of	IN
cord-006229-7yoilsho	2647	13	tetrameric	tetrameric	JJ
cord-006229-7yoilsho	2647	14	nonselective	nonselective	JJ
cord-006229-7yoilsho	2647	15	cation	cation	NN
cord-006229-7yoilsho	2647	16	channels	channel	NNS
cord-006229-7yoilsho	2647	17	,	,	,
cord-006229-7yoilsho	2647	18	which	which	WDT
cord-006229-7yoilsho	2647	19	are	be	VBP
cord-006229-7yoilsho	2647	20	involved	involve	VBN
cord-006229-7yoilsho	2647	21	in	in	IN
cord-006229-7yoilsho	2647	22	a	a	DT
cord-006229-7yoilsho	2647	23	variety	variety	NN
cord-006229-7yoilsho	2647	24	of	of	IN
cord-006229-7yoilsho	2647	25	physiological	physiological	JJ
cord-006229-7yoilsho	2647	26	and	and	CC
cord-006229-7yoilsho	2647	27	pathological	pathological	JJ
cord-006229-7yoilsho	2647	28	processes	process	NNS
cord-006229-7yoilsho	2647	29	(	(	-LRB-
cord-006229-7yoilsho	2647	30	1	1	CD
cord-006229-7yoilsho	2647	31	)	)	-RRB-
cord-006229-7yoilsho	2647	32	.	.	.
cord-006229-7yoilsho	2648	1	Among	among	IN
cord-006229-7yoilsho	2648	2	the	the	DT
cord-006229-7yoilsho	2648	3	28	28	CD
cord-006229-7yoilsho	2648	4	mammalian	mammalian	JJ
cord-006229-7yoilsho	2648	5	TRP	trp	NN
cord-006229-7yoilsho	2648	6	channels	channel	NNS
cord-006229-7yoilsho	2648	7	,	,	,
cord-006229-7yoilsho	2648	8	the	the	DT
cord-006229-7yoilsho	2648	9	canonical	canonical	JJ
cord-006229-7yoilsho	2648	10	channel	channel	NN
cord-006229-7yoilsho	2648	11	5	5	CD
cord-006229-7yoilsho	2648	12	(	(	-LRB-
cord-006229-7yoilsho	2648	13	TRPC5	trpc5	NN
cord-006229-7yoilsho	2648	14	)	)	-RRB-
cord-006229-7yoilsho	2648	15	is	be	VBZ
cord-006229-7yoilsho	2648	16	a	a	DT
cord-006229-7yoilsho	2648	17	Ca	Ca	NNP
cord-006229-7yoilsho	2648	18	2	2	CD
cord-006229-7yoilsho	2648	19	+	+	CC
cord-006229-7yoilsho	2648	20	-permeable	-permeable	JJ
cord-006229-7yoilsho	2648	21	ion	ion	NN
cord-006229-7yoilsho	2648	22	channel	channel	NN
cord-006229-7yoilsho	2648	23	,	,	,
cord-006229-7yoilsho	2648	24	which	which	WDT
cord-006229-7yoilsho	2648	25	is	be	VBZ
cord-006229-7yoilsho	2648	26	predominantly	predominantly	RB
cord-006229-7yoilsho	2648	27	expressed	express	VBN
cord-006229-7yoilsho	2648	28	in	in	IN
cord-006229-7yoilsho	2648	29	the	the	DT
cord-006229-7yoilsho	2648	30	brain	brain	NN
cord-006229-7yoilsho	2648	31	(	(	-LRB-
cord-006229-7yoilsho	2648	32	2	2	CD
cord-006229-7yoilsho	2648	33	)	)	-RRB-
cord-006229-7yoilsho	2648	34	.	.	.
cord-006229-7yoilsho	2649	1	Many	many	JJ
cord-006229-7yoilsho	2649	2	aspects	aspect	NNS
cord-006229-7yoilsho	2649	3	of	of	IN
cord-006229-7yoilsho	2649	4	TRPC5	trpc5	DT
cord-006229-7yoilsho	2649	5	function	function	NN
cord-006229-7yoilsho	2649	6	are	be	VBP
cord-006229-7yoilsho	2649	7	still	still	RB
cord-006229-7yoilsho	2649	8	elusive	elusive	JJ
cord-006229-7yoilsho	2649	9	although	although	IN
cord-006229-7yoilsho	2649	10	behavioral	behavioral	JJ
cord-006229-7yoilsho	2649	11	experiments	experiment	NNS
cord-006229-7yoilsho	2649	12	with	with	IN
cord-006229-7yoilsho	2649	13	TRPC5-knock	TRPC5-knock	NNP
cord-006229-7yoilsho	2649	14	-	-	HYPH
cord-006229-7yoilsho	2649	15	out	out	RP
cord-006229-7yoilsho	2649	16	mice	mouse	NNS
cord-006229-7yoilsho	2649	17	suggest	suggest	VBP
cord-006229-7yoilsho	2649	18	a	a	DT
cord-006229-7yoilsho	2649	19	role	role	NN
cord-006229-7yoilsho	2649	20	in	in	IN
cord-006229-7yoilsho	2649	21	innate	innate	JJ
cord-006229-7yoilsho	2649	22	fear	fear	NN
cord-006229-7yoilsho	2649	23	-	-	HYPH
cord-006229-7yoilsho	2649	24	response	response	NN
cord-006229-7yoilsho	2649	25	(	(	-LRB-
cord-006229-7yoilsho	2649	26	3	3	CD
cord-006229-7yoilsho	2649	27	)	)	-RRB-
cord-006229-7yoilsho	2649	28	and	and	CC
cord-006229-7yoilsho	2649	29	some	some	DT
cord-006229-7yoilsho	2649	30	studies	study	NNS
cord-006229-7yoilsho	2649	31	indicate	indicate	VBP
cord-006229-7yoilsho	2649	32	a	a	DT
cord-006229-7yoilsho	2649	33	TRPC5-mediated	TRPC5-mediated	NNP
cord-006229-7yoilsho	2649	34	down	down	IN
cord-006229-7yoilsho	2649	35	regulation	regulation	NN
cord-006229-7yoilsho	2649	36	of	of	IN
cord-006229-7yoilsho	2649	37	neurite	neurite	NN
cord-006229-7yoilsho	2649	38	outgrowth	outgrowth	NN
cord-006229-7yoilsho	2649	39	in	in	IN
cord-006229-7yoilsho	2649	40	nerve	nerve	NN
cord-006229-7yoilsho	2649	41	cells	cell	NNS
cord-006229-7yoilsho	2649	42	(	(	-LRB-
cord-006229-7yoilsho	2649	43	4	4	CD
cord-006229-7yoilsho	2649	44	,	,	,
cord-006229-7yoilsho	2649	45	5	5	CD
cord-006229-7yoilsho	2649	46	)	)	-RRB-
cord-006229-7yoilsho	2649	47	.	.	.
cord-006229-7yoilsho	2650	1	To	to	TO
cord-006229-7yoilsho	2650	2	elucidate	elucidate	VB
cord-006229-7yoilsho	2650	3	TRPC5	trpc5	NN
cord-006229-7yoilsho	2650	4	function	function	NN
cord-006229-7yoilsho	2650	5	on	on	IN
cord-006229-7yoilsho	2650	6	a	a	DT
cord-006229-7yoilsho	2650	7	cellular	cellular	JJ
cord-006229-7yoilsho	2650	8	level	level	NN
cord-006229-7yoilsho	2650	9	,	,	.
cord-006229-7yoilsho	2651	1	selective	selective	JJ
cord-006229-7yoilsho	2651	2	and	and	CC
cord-006229-7yoilsho	2651	3	potent	potent	JJ
cord-006229-7yoilsho	2651	4	compounds	compound	NNS
cord-006229-7yoilsho	2651	5	are	be	VBP
cord-006229-7yoilsho	2651	6	required	require	VBN
cord-006229-7yoilsho	2651	7	to	to	TO
cord-006229-7yoilsho	2651	8	acutely	acutely	RB
cord-006229-7yoilsho	2651	9	control	control	VB
cord-006229-7yoilsho	2651	10	channel	channel	NN
cord-006229-7yoilsho	2651	11	activity	activity	NN
cord-006229-7yoilsho	2651	12	.	.	.
cord-006229-7yoilsho	2652	1	Despite	despite	IN
cord-006229-7yoilsho	2652	2	extensive	extensive	JJ
cord-006229-7yoilsho	2652	3	research	research	NN
cord-006229-7yoilsho	2652	4	,	,	,
cord-006229-7yoilsho	2652	5	TRPC5	trpc5	NN
cord-006229-7yoilsho	2652	6	modulators	modulator	NNS
cord-006229-7yoilsho	2652	7	often	often	RB
cord-006229-7yoilsho	2652	8	lack	lack	VBP
cord-006229-7yoilsho	2652	9	selectivity	selectivity	NN
cord-006229-7yoilsho	2652	10	or	or	CC
cord-006229-7yoilsho	2652	11	exhibit	exhibit	NN
cord-006229-7yoilsho	2652	12	toxicity	toxicity	NN
cord-006229-7yoilsho	2652	13	,	,	,
cord-006229-7yoilsho	2652	14	limiting	limit	VBG
cord-006229-7yoilsho	2652	15	their	-PRON-	PRP$
cord-006229-7yoilsho	2652	16	applicability	applicability	NN
cord-006229-7yoilsho	2652	17	in	in	IN
cord-006229-7yoilsho	2652	18	vivo	vivo	NNP
cord-006229-7yoilsho	2652	19	(	(	-LRB-
cord-006229-7yoilsho	2652	20	6	6	CD
cord-006229-7yoilsho	2652	21	,	,	,
cord-006229-7yoilsho	2652	22	7	7	CD
cord-006229-7yoilsho	2652	23	)	)	-RRB-
cord-006229-7yoilsho	2652	24	.	.	.
cord-006229-7yoilsho	2653	1	Thus	thus	RB
cord-006229-7yoilsho	2653	2	,	,	,
cord-006229-7yoilsho	2653	3	there	there	EX
cord-006229-7yoilsho	2653	4	is	be	VBZ
cord-006229-7yoilsho	2653	5	still	still	RB
cord-006229-7yoilsho	2653	6	a	a	DT
cord-006229-7yoilsho	2653	7	need	need	NN
cord-006229-7yoilsho	2653	8	for	for	IN
cord-006229-7yoilsho	2653	9	identifying	identify	VBG
cord-006229-7yoilsho	2653	10	novel	novel	JJ
cord-006229-7yoilsho	2653	11	and	and	CC
cord-006229-7yoilsho	2653	12	efficient	efficient	JJ
cord-006229-7yoilsho	2653	13	TRPC5	trpc5	NN
cord-006229-7yoilsho	2653	14	modulators	modulator	NNS
cord-006229-7yoilsho	2653	15	.	.	.
cord-006229-7yoilsho	2654	1	We	-PRON-	PRP
cord-006229-7yoilsho	2654	2	therefore	therefore	RB
cord-006229-7yoilsho	2654	3	screened	screen	VBD
cord-006229-7yoilsho	2654	4	a	a	DT
cord-006229-7yoilsho	2654	5	compound	compound	NN
cord-006229-7yoilsho	2654	6	library	library	NN
cord-006229-7yoilsho	2654	7	(	(	-LRB-
cord-006229-7yoilsho	2654	8	ChemBioNet	ChemBioNet	NNP
cord-006229-7yoilsho	2654	9	)	)	-RRB-
cord-006229-7yoilsho	2654	10	and	and	CC
cord-006229-7yoilsho	2654	11	identified	identify	VBD
cord-006229-7yoilsho	2654	12	a	a	DT
cord-006229-7yoilsho	2654	13	benzothiadiazine	benzothiadiazine	NN
cord-006229-7yoilsho	2654	14	derivative	derivative	NN
cord-006229-7yoilsho	2654	15	(	(	-LRB-
cord-006229-7yoilsho	2654	16	BTD	BTD	NNP
cord-006229-7yoilsho	2654	17	)	)	-RRB-
cord-006229-7yoilsho	2654	18	as	as	IN
cord-006229-7yoilsho	2654	19	a	a	DT
cord-006229-7yoilsho	2654	20	novel	novel	NN
cord-006229-7yoilsho	2654	21	,	,	,
cord-006229-7yoilsho	2654	22	potent	potent	JJ
cord-006229-7yoilsho	2654	23	,	,	,
cord-006229-7yoilsho	2654	24	and	and	CC
cord-006229-7yoilsho	2654	25	selective	selective	JJ
cord-006229-7yoilsho	2654	26	TRPC5	trpc5	NN
cord-006229-7yoilsho	2654	27	activator	activator	NN
cord-006229-7yoilsho	2654	28	.	.	.
cord-006229-7yoilsho	2655	1	HEK293	HEK293	NNP
cord-006229-7yoilsho	2655	2	cells	cell	NNS
cord-006229-7yoilsho	2655	3	heterologously	heterologously	RB
cord-006229-7yoilsho	2655	4	expressing	express	VBG
cord-006229-7yoilsho	2655	5	TRPC5	trpc5	NN
cord-006229-7yoilsho	2655	6	upon	upon	IN
cord-006229-7yoilsho	2655	7	tetracycline	tetracycline	NNP
cord-006229-7yoilsho	2655	8	induction	induction	NN
cord-006229-7yoilsho	2655	9	(	(	-LRB-
cord-006229-7yoilsho	2655	10	HEK	HEK	NNP
cord-006229-7yoilsho	2655	11	TRPC5	trpc5	ADD
cord-006229-7yoilsho	2655	12	)	)	-RRB-
cord-006229-7yoilsho	2655	13	show	show	VBP
cord-006229-7yoilsho	2655	14	a	a	DT
cord-006229-7yoilsho	2655	15	BTD	BTD	NNP
cord-006229-7yoilsho	2655	16	-	-	HYPH
cord-006229-7yoilsho	2655	17	induced	induce	VBN
cord-006229-7yoilsho	2655	18	concentration	concentration	NN
cord-006229-7yoilsho	2655	19	-	-	HYPH
cord-006229-7yoilsho	2655	20	dependent	dependent	JJ
cord-006229-7yoilsho	2655	21	activation	activation	NN
cord-006229-7yoilsho	2655	22	in	in	IN
cord-006229-7yoilsho	2655	23	both	both	DT
cord-006229-7yoilsho	2655	24	Ca	Ca	NNP
cord-006229-7yoilsho	2655	25	2	2	CD
cord-006229-7yoilsho	2655	26	+	+	SYM
cord-006229-7yoilsho	2655	27	assays	assay	NNS
cord-006229-7yoilsho	2655	28	(	(	-LRB-
cord-006229-7yoilsho	2655	29	EC	EC	NNP
cord-006229-7yoilsho	2655	30	50	50	CD
cord-006229-7yoilsho	2655	31	=	=	SYM
cord-006229-7yoilsho	2655	32	0.71	0.71	CD
cord-006229-7yoilsho	2655	33	µM	µM	NNP
cord-006229-7yoilsho	2655	34	)	)	-RRB-
cord-006229-7yoilsho	2655	35	and	and	CC
cord-006229-7yoilsho	2655	36	in	in	IN
cord-006229-7yoilsho	2655	37	electrophysiological	electrophysiological	JJ
cord-006229-7yoilsho	2655	38	whole	whole	JJ
cord-006229-7yoilsho	2655	39	cell	cell	NN
cord-006229-7yoilsho	2655	40	patch	patch	NN
cord-006229-7yoilsho	2655	41	clamp	clamp	NN
cord-006229-7yoilsho	2655	42	recordings	recording	NNS
cord-006229-7yoilsho	2656	1	(	(	-LRB-
cord-006229-7yoilsho	2656	2	EC	EC	NNP
cord-006229-7yoilsho	2656	3	50	50	CD
cord-006229-7yoilsho	2656	4	=	=	SYM
cord-006229-7yoilsho	2656	5	1.1	1.1	CD
cord-006229-7yoilsho	2656	6	µM	µm	CD
cord-006229-7yoilsho	2656	7	)	)	-RRB-
cord-006229-7yoilsho	2656	8	.	.	.
cord-006229-7yoilsho	2657	1	BTD	BTD	NNP
cord-006229-7yoilsho	2657	2	elicits	elicit	VBZ
cord-006229-7yoilsho	2657	3	currents	current	NNS
cord-006229-7yoilsho	2657	4	with	with	IN
cord-006229-7yoilsho	2657	5	an	an	DT
cord-006229-7yoilsho	2657	6	N	n	CD
cord-006229-7yoilsho	2657	7	-	-	HYPH
cord-006229-7yoilsho	2657	8	shaped	shape	VBN
cord-006229-7yoilsho	2657	9	I	I	NNP
cord-006229-7yoilsho	2657	10	/	/	SYM
cord-006229-7yoilsho	2657	11	V	v	NN
cord-006229-7yoilsho	2657	12	curve	curve	NN
cord-006229-7yoilsho	2657	13	,	,	,
cord-006229-7yoilsho	2657	14	typical	typical	JJ
cord-006229-7yoilsho	2657	15	for	for	IN
cord-006229-7yoilsho	2657	16	TRPC5	trpc5	ADD
cord-006229-7yoilsho	2657	17	.	.	.
cord-006229-7yoilsho	2658	1	The	the	DT
cord-006229-7yoilsho	2658	2	resulting	result	VBG
cord-006229-7yoilsho	2658	3	activation	activation	NN
cord-006229-7yoilsho	2658	4	is	be	VBZ
cord-006229-7yoilsho	2658	5	long	long	RB
cord-006229-7yoilsho	2658	6	lasting	lasting	JJ
cord-006229-7yoilsho	2658	7	,	,	,
cord-006229-7yoilsho	2658	8	reversible	reversible	JJ
cord-006229-7yoilsho	2658	9	and	and	CC
cord-006229-7yoilsho	2658	10	sensitive	sensitive	JJ
cord-006229-7yoilsho	2658	11	to	to	IN
cord-006229-7yoilsho	2658	12	clemizole	clemizole	NNP
cord-006229-7yoilsho	2658	13	,	,	,
cord-006229-7yoilsho	2658	14	a	a	DT
cord-006229-7yoilsho	2658	15	recently	recently	RB
cord-006229-7yoilsho	2658	16	established	establish	VBN
cord-006229-7yoilsho	2658	17	TRPC5	trpc5	NN
cord-006229-7yoilsho	2658	18	inhibitor	inhibitor	NN
cord-006229-7yoilsho	2658	19	(	(	-LRB-
cord-006229-7yoilsho	2658	20	8)	8)	NN
cord-006229-7yoilsho	2658	21	.	.	.
cord-006229-7yoilsho	2659	1	MTT	MTT	NNP
cord-006229-7yoilsho	2659	2	assays	assay	NNS
cord-006229-7yoilsho	2659	3	revealed	reveal	VBD
cord-006229-7yoilsho	2659	4	that	that	IN
cord-006229-7yoilsho	2659	5	incubating	incubate	VBG
cord-006229-7yoilsho	2659	6	HEK	HEK	NNP
cord-006229-7yoilsho	2659	7	TRPC5	trpc5	NN
cord-006229-7yoilsho	2659	8	cells	cell	NNS
cord-006229-7yoilsho	2659	9	for	for	IN
cord-006229-7yoilsho	2659	10	24h	24h	NNS
cord-006229-7yoilsho	2659	11	with	with	IN
cord-006229-7yoilsho	2659	12	BTD	BTD	NNP
cord-006229-7yoilsho	2659	13	concentrations	concentration	NNS
cord-006229-7yoilsho	2659	14	above	above	IN
cord-006229-7yoilsho	2659	15	1	1	CD
cord-006229-7yoilsho	2659	16	µM	µm	CD
cord-006229-7yoilsho	2659	17	results	result	NNS
cord-006229-7yoilsho	2659	18	in	in	IN
cord-006229-7yoilsho	2659	19	a	a	DT
cord-006229-7yoilsho	2659	20	concentration	concentration	NN
cord-006229-7yoilsho	2659	21	-	-	HYPH
cord-006229-7yoilsho	2659	22	dependent	dependent	JJ
cord-006229-7yoilsho	2659	23	decrease	decrease	NN
cord-006229-7yoilsho	2659	24	in	in	IN
cord-006229-7yoilsho	2659	25	viability	viability	NN
cord-006229-7yoilsho	2659	26	and	and	CC
cord-006229-7yoilsho	2659	27	cell	cell	NN
cord-006229-7yoilsho	2659	28	proliferation	proliferation	NN
cord-006229-7yoilsho	2659	29	,	,	,
cord-006229-7yoilsho	2659	30	indicating	indicate	VBG
cord-006229-7yoilsho	2659	31	a	a	DT
cord-006229-7yoilsho	2659	32	Ca	Ca	NNP
cord-006229-7yoilsho	2659	33	2	2	CD
cord-006229-7yoilsho	2659	34	+	+	SYM
cord-006229-7yoilsho	2659	35	-mediated	-mediated	JJ
cord-006229-7yoilsho	2659	36	cytotoxic	cytotoxic	JJ
cord-006229-7yoilsho	2659	37	effect	effect	NN
cord-006229-7yoilsho	2659	38	in	in	IN
cord-006229-7yoilsho	2659	39	consequence	consequence	NN
cord-006229-7yoilsho	2659	40	of	of	IN
cord-006229-7yoilsho	2659	41	sustained	sustained	JJ
cord-006229-7yoilsho	2659	42	channel	channel	NN
cord-006229-7yoilsho	2659	43	activity	activity	NN
cord-006229-7yoilsho	2659	44	.	.	.
cord-006229-7yoilsho	2660	1	Non	non	JJ
cord-006229-7yoilsho	2660	2	-	-	JJ
cord-006229-7yoilsho	2660	3	induced	induce	VBN
cord-006229-7yoilsho	2660	4	control	control	NN
cord-006229-7yoilsho	2660	5	cells	cell	NNS
cord-006229-7yoilsho	2660	6	remain	remain	VBP
cord-006229-7yoilsho	2660	7	unaffected	unaffected	JJ
cord-006229-7yoilsho	2660	8	by	by	IN
cord-006229-7yoilsho	2660	9	BTD	BTD	NNP
cord-006229-7yoilsho	2660	10	at	at	IN
cord-006229-7yoilsho	2660	11	concentrations	concentration	NNS
cord-006229-7yoilsho	2660	12	up	up	IN
cord-006229-7yoilsho	2660	13	to	to	IN
cord-006229-7yoilsho	2660	14	10	10	CD
cord-006229-7yoilsho	2661	1	µM.	µM.	NNP
cord-006229-7yoilsho	2662	1	Ca	ca	NN
cord-006229-7yoilsho	2662	2	2	2	CD
cord-006229-7yoilsho	2662	3	+	+	CD
cord-006229-7yoilsho	2663	1	assays	assay	NNS
cord-006229-7yoilsho	2663	2	showed	show	VBD
cord-006229-7yoilsho	2663	3	no	no	DT
cord-006229-7yoilsho	2663	4	influence	influence	NN
cord-006229-7yoilsho	2663	5	of	of	IN
cord-006229-7yoilsho	2663	6	BTD	BTD	NNP
cord-006229-7yoilsho	2663	7	on	on	IN
cord-006229-7yoilsho	2663	8	closely	closely	RB
cord-006229-7yoilsho	2663	9	related	relate	VBN
cord-006229-7yoilsho	2663	10	TRPC4	trpc4	JJ
cord-006229-7yoilsho	2663	11	channels	channel	NNS
cord-006229-7yoilsho	2663	12	,	,	,
cord-006229-7yoilsho	2663	13	as	as	RB
cord-006229-7yoilsho	2663	14	well	well	RB
cord-006229-7yoilsho	2663	15	as	as	IN
cord-006229-7yoilsho	2663	16	TRPC3/6/7	TRPC3/6/7	NNP
cord-006229-7yoilsho	2663	17	at	at	IN
cord-006229-7yoilsho	2663	18	concentrations	concentration	NNS
cord-006229-7yoilsho	2664	1	up	up	IN
cord-006229-7yoilsho	2664	2	to	to	TO
cord-006229-7yoilsho	2664	3	10	10	CD
cord-006229-7yoilsho	2664	4	µM.	µm.	NN
cord-006229-7yoilsho	2665	1	The	the	DT
cord-006229-7yoilsho	2665	2	same	same	JJ
cord-006229-7yoilsho	2665	3	applied	apply	VBD
cord-006229-7yoilsho	2665	4	to	to	IN
cord-006229-7yoilsho	2665	5	more	more	RBR
cord-006229-7yoilsho	2665	6	distantly	distantly	RB
cord-006229-7yoilsho	2665	7	related	relate	VBN
cord-006229-7yoilsho	2665	8	TRPV	TRPV	NNS
cord-006229-7yoilsho	2665	9	and	and	CC
cord-006229-7yoilsho	2665	10	TRPM	trpm	NN
cord-006229-7yoilsho	2665	11	channels	channel	NNS
cord-006229-7yoilsho	2665	12	.	.	.
cord-006229-7yoilsho	2666	1	Besides	besides	IN
cord-006229-7yoilsho	2666	2	a	a	DT
cord-006229-7yoilsho	2666	3	homotetrameric	homotetrameric	NN
cord-006229-7yoilsho	2666	4	organization	organization	NN
cord-006229-7yoilsho	2666	5	,	,	,
cord-006229-7yoilsho	2666	6	TRPC5	trpc5	NN
cord-006229-7yoilsho	2666	7	subunits	subunit	NNS
cord-006229-7yoilsho	2666	8	can	can	MD
cord-006229-7yoilsho	2666	9	also	also	RB
cord-006229-7yoilsho	2666	10	assemble	assemble	VB
cord-006229-7yoilsho	2666	11	to	to	IN
cord-006229-7yoilsho	2666	12	heteromeric	heteromeric	NNP
cord-006229-7yoilsho	2666	13	channel	channel	NN
cord-006229-7yoilsho	2666	14	complexes	complex	NNS
cord-006229-7yoilsho	2666	15	with	with	IN
cord-006229-7yoilsho	2666	16	their	-PRON-	PRP$
cord-006229-7yoilsho	2666	17	closest	close	JJS
cord-006229-7yoilsho	2666	18	relatives	relative	NNS
cord-006229-7yoilsho	2666	19	TRPC1	TRPC1	NNP
cord-006229-7yoilsho	2667	1	and	and	CC
cord-006229-7yoilsho	2667	2	TRPC4	TRPC4	NNP
cord-006229-7yoilsho	2667	3	(	(	-LRB-
cord-006229-7yoilsho	2667	4	9	9	CD
cord-006229-7yoilsho	2667	5	)	)	-RRB-
cord-006229-7yoilsho	2667	6	.	.	.
cord-006229-7yoilsho	2668	1	TRPC1/5	TRPC1/5	NNP
cord-006229-7yoilsho	2668	2	and	and	CC
cord-006229-7yoilsho	2668	3	TRPC4/5	TRPC4/5	NNP
cord-006229-7yoilsho	2668	4	heteromers	heteromer	NNS
cord-006229-7yoilsho	2668	5	can	can	MD
cord-006229-7yoilsho	2668	6	also	also	RB
cord-006229-7yoilsho	2668	7	be	be	VB
cord-006229-7yoilsho	2668	8	activated	activate	VBN
cord-006229-7yoilsho	2668	9	by	by	IN
cord-006229-7yoilsho	2668	10	BTD	BTD	NNP
cord-006229-7yoilsho	2668	11	as	as	IN
cord-006229-7yoilsho	2668	12	evident	evident	JJ
cord-006229-7yoilsho	2668	13	from	from	IN
cord-006229-7yoilsho	2668	14	their	-PRON-	PRP$
cord-006229-7yoilsho	2668	15	typical	typical	JJ
cord-006229-7yoilsho	2668	16	I	I	NNP
cord-006229-7yoilsho	2668	17	/	/	SYM
cord-006229-7yoilsho	2668	18	V	v	NN
cord-006229-7yoilsho	2668	19	curves	curve	NNS
cord-006229-7yoilsho	2668	20	in	in	IN
cord-006229-7yoilsho	2668	21	patch	patch	NN
cord-006229-7yoilsho	2668	22	clamp	clamp	NN
cord-006229-7yoilsho	2668	23	experiments	experiment	NNS
cord-006229-7yoilsho	2668	24	,	,	,
cord-006229-7yoilsho	2668	25	suggesting	suggest	VBG
cord-006229-7yoilsho	2668	26	a	a	DT
cord-006229-7yoilsho	2668	27	high	high	JJ
cord-006229-7yoilsho	2668	28	selectivity	selectivity	NN
cord-006229-7yoilsho	2668	29	of	of	IN
cord-006229-7yoilsho	2668	30	BTD	BTD	NNP
cord-006229-7yoilsho	2668	31	for	for	IN
cord-006229-7yoilsho	2668	32	channel	channel	NN
cord-006229-7yoilsho	2668	33	complexes	complex	NNS
cord-006229-7yoilsho	2668	34	bearing	bear	VBG
cord-006229-7yoilsho	2668	35	at	at	RB
cord-006229-7yoilsho	2668	36	least	least	RBS
cord-006229-7yoilsho	2668	37	one	one	CD
cord-006229-7yoilsho	2668	38	TRPC5	trpc5	NN
cord-006229-7yoilsho	2668	39	subunit	subunit	NN
cord-006229-7yoilsho	2668	40	.	.	.
cord-006229-7yoilsho	2669	1	Transient	transient	JJ
cord-006229-7yoilsho	2669	2	receptor	receptor	NN
cord-006229-7yoilsho	2669	3	potential	potential	JJ
cord-006229-7yoilsho	2669	4	canonical	canonical	JJ
cord-006229-7yoilsho	2669	5	channels	channel	NNS
cord-006229-7yoilsho	2669	6	3/6	3/6	CD
cord-006229-7yoilsho	2669	7	and	and	CC
cord-006229-7yoilsho	2669	8	7	7	CD
cord-006229-7yoilsho	2669	9	are	be	VBP
cord-006229-7yoilsho	2669	10	controlled	control	VBN
cord-006229-7yoilsho	2669	11	by	by	IN
cord-006229-7yoilsho	2669	12	membrane	membrane	NN
cord-006229-7yoilsho	2669	13	lipids	lipid	NNS
cord-006229-7yoilsho	2669	14	and	and	CC
cord-006229-7yoilsho	2669	15	highly	highly	RB
cord-006229-7yoilsho	2669	16	expressed	express	VBN
cord-006229-7yoilsho	2669	17	in	in	IN
cord-006229-7yoilsho	2669	18	neuronal	neuronal	JJ
cord-006229-7yoilsho	2669	19	and	and	CC
cord-006229-7yoilsho	2669	20	cardiac	cardiac	JJ
cord-006229-7yoilsho	2669	21	tissues	tissue	NNS
cord-006229-7yoilsho	2669	22	.	.	.
cord-006229-7yoilsho	2670	1	The	the	DT
cord-006229-7yoilsho	2670	2	involvement	involvement	NN
cord-006229-7yoilsho	2670	3	of	of	IN
cord-006229-7yoilsho	2670	4	these	these	DT
cord-006229-7yoilsho	2670	5	channels	channel	NNS
cord-006229-7yoilsho	2670	6	in	in	IN
cord-006229-7yoilsho	2670	7	development	development	NN
cord-006229-7yoilsho	2670	8	and	and	CC
cord-006229-7yoilsho	2670	9	(	(	-LRB-
cord-006229-7yoilsho	2670	10	patho)physiology	patho)physiology	NN
cord-006229-7yoilsho	2670	11	of	of	IN
cord-006229-7yoilsho	2670	12	these	these	DT
cord-006229-7yoilsho	2670	13	tissues	tissue	NNS
cord-006229-7yoilsho	2670	14	is	be	VBZ
cord-006229-7yoilsho	2670	15	well	well	RB
cord-006229-7yoilsho	2670	16	documented	document	VBN
cord-006229-7yoilsho	2670	17	,	,	,
cord-006229-7yoilsho	2670	18	while	while	IN
cord-006229-7yoilsho	2670	19	our	-PRON-	PRP$
cord-006229-7yoilsho	2670	20	understanding	understanding	NN
cord-006229-7yoilsho	2670	21	of	of	IN
cord-006229-7yoilsho	2670	22	structure	structure	NN
cord-006229-7yoilsho	2670	23	-	-	HYPH
cord-006229-7yoilsho	2670	24	function	function	NN
cord-006229-7yoilsho	2670	25	relations	relation	NNS
cord-006229-7yoilsho	2670	26	,	,	,
cord-006229-7yoilsho	2670	27	specifically	specifically	RB
cord-006229-7yoilsho	2670	28	in	in	IN
cord-006229-7yoilsho	2670	29	terms	term	NNS
cord-006229-7yoilsho	2670	30	of	of	IN
cord-006229-7yoilsho	2670	31	the	the	DT
cord-006229-7yoilsho	2670	32	lipid	lipid	NN
cord-006229-7yoilsho	2670	33	sensing	sensing	NN
cord-006229-7yoilsho	2670	34	machinery	machinery	NN
cord-006229-7yoilsho	2670	35	,	,	,
cord-006229-7yoilsho	2670	36	in	in	IN
cord-006229-7yoilsho	2670	37	these	these	DT
cord-006229-7yoilsho	2670	38	channel	channel	NN
cord-006229-7yoilsho	2670	39	proteins	protein	NNS
cord-006229-7yoilsho	2670	40	is	be	VBZ
cord-006229-7yoilsho	2670	41	still	still	RB
cord-006229-7yoilsho	2670	42	incomplete	incomplete	JJ
cord-006229-7yoilsho	2670	43	.	.	.
cord-006229-7yoilsho	2671	1	Using	use	VBG
cord-006229-7yoilsho	2671	2	a	a	DT
cord-006229-7yoilsho	2671	3	homology	homology	NN
cord-006229-7yoilsho	2671	4	model	model	NN
cord-006229-7yoilsho	2671	5	of	of	IN
cord-006229-7yoilsho	2671	6	TRPC3	TRPC3	NNP
cord-006229-7yoilsho	2671	7	,	,	,
cord-006229-7yoilsho	2671	8	based	base	VBN
cord-006229-7yoilsho	2671	9	on	on	IN
cord-006229-7yoilsho	2671	10	the	the	DT
cord-006229-7yoilsho	2671	11	recently	recently	RB
cord-006229-7yoilsho	2671	12	available	available	JJ
cord-006229-7yoilsho	2671	13	structural	structural	JJ
cord-006229-7yoilsho	2671	14	information	information	NN
cord-006229-7yoilsho	2671	15	on	on	IN
cord-006229-7yoilsho	2671	16	TRPV1	TRPV1	NNP
cord-006229-7yoilsho	2671	17	,	,	,
cord-006229-7yoilsho	2671	18	we	-PRON-	PRP
cord-006229-7yoilsho	2671	19	performed	perform	VBD
cord-006229-7yoilsho	2671	20	structure	structure	NN
cord-006229-7yoilsho	2671	21	-	-	HYPH
cord-006229-7yoilsho	2671	22	guided	guide	VBN
cord-006229-7yoilsho	2671	23	mutagenesis	mutagenesis	NN
cord-006229-7yoilsho	2671	24	and	and	CC
cord-006229-7yoilsho	2671	25	identified	identify	VBD
cord-006229-7yoilsho	2671	26	a	a	DT
cord-006229-7yoilsho	2671	27	single	single	JJ
cord-006229-7yoilsho	2671	28	residue	residue	NN
cord-006229-7yoilsho	2671	29	in	in	IN
cord-006229-7yoilsho	2671	30	transmembrane	transmembrane	NN
cord-006229-7yoilsho	2671	31	domain	domain	NN
cord-006229-7yoilsho	2671	32	6	6	CD
cord-006229-7yoilsho	2671	33	(	(	-LRB-
cord-006229-7yoilsho	2671	34	G652	G652	NNP
cord-006229-7yoilsho	2671	35	)	)	-RRB-
cord-006229-7yoilsho	2671	36	,	,	,
cord-006229-7yoilsho	2671	37	which	which	WDT
cord-006229-7yoilsho	2671	38	is	be	VBZ
cord-006229-7yoilsho	2671	39	conserved	conserve	VBN
cord-006229-7yoilsho	2671	40	within	within	IN
cord-006229-7yoilsho	2671	41	the	the	DT
cord-006229-7yoilsho	2671	42	canonical	canonical	JJ
cord-006229-7yoilsho	2671	43	family	family	NN
cord-006229-7yoilsho	2671	44	of	of	IN
cord-006229-7yoilsho	2671	45	TRP	TRP	NNP
cord-006229-7yoilsho	2671	46	channels	channel	NNS
cord-006229-7yoilsho	2671	47	.	.	.
cord-006229-7yoilsho	2672	1	Single	single	JJ
cord-006229-7yoilsho	2672	2	point	point	NN
cord-006229-7yoilsho	2672	3	mutations	mutation	NNS
cord-006229-7yoilsho	2672	4	at	at	IN
cord-006229-7yoilsho	2672	5	position	position	NN
cord-006229-7yoilsho	2672	6	652	652	CD
cord-006229-7yoilsho	2672	7	in	in	IN
cord-006229-7yoilsho	2672	8	TRPC3	TRPC3	NNP
cord-006229-7yoilsho	2672	9	largely	largely	RB
cord-006229-7yoilsho	2672	10	eliminated	eliminate	VBN
cord-006229-7yoilsho	2672	11	lipid	lipid	NN
cord-006229-7yoilsho	2672	12	sensitivity	sensitivity	NN
cord-006229-7yoilsho	2672	13	.	.	.
cord-006229-7yoilsho	2673	1	TRPC3	trpc3	XX
cord-006229-7yoilsho	2674	1	G652A	G652A	NNP
cord-006229-7yoilsho	2674	2	expressed	express	VBN
cord-006229-7yoilsho	2674	3	in	in	IN
cord-006229-7yoilsho	2674	4	HEK293	HEK293	NNP
cord-006229-7yoilsho	2674	5	cells	cell	NNS
cord-006229-7yoilsho	2674	6	was	be	VBD
cord-006229-7yoilsho	2674	7	found	find	VBN
cord-006229-7yoilsho	2674	8	resistant	resistant	JJ
cord-006229-7yoilsho	2674	9	not	not	RB
cord-006229-7yoilsho	2674	10	only	only	RB
cord-006229-7yoilsho	2674	11	to	to	TO
cord-006229-7yoilsho	2674	12	activation	activation	VB
cord-006229-7yoilsho	2674	13	via	via	IN
cord-006229-7yoilsho	2674	14	the	the	DT
cord-006229-7yoilsho	2674	15	phospholipase	phospholipase	NN
cord-006229-7yoilsho	2674	16	C	C	NNP
cord-006229-7yoilsho	2674	17	pathway	pathway	NN
cord-006229-7yoilsho	2674	18	but	but	CC
cord-006229-7yoilsho	2674	19	also	also	RB
cord-006229-7yoilsho	2674	20	to	to	TO
cord-006229-7yoilsho	2674	21	direct	direct	VB
cord-006229-7yoilsho	2674	22	administration	administration	NN
cord-006229-7yoilsho	2674	23	of	of	IN
cord-006229-7yoilsho	2674	24	diacylglycerols	diacylglycerol	NNS
cord-006229-7yoilsho	2674	25	.	.	.
cord-006229-7yoilsho	2675	1	On	on	IN
cord-006229-7yoilsho	2675	2	the	the	DT
cord-006229-7yoilsho	2675	3	contrary	contrary	NN
cord-006229-7yoilsho	2675	4	,	,	,
cord-006229-7yoilsho	2675	5	a	a	DT
cord-006229-7yoilsho	2675	6	synthetic	synthetic	JJ
cord-006229-7yoilsho	2675	7	agonist	agonist	NN
cord-006229-7yoilsho	2675	8	of	of	IN
cord-006229-7yoilsho	2675	9	TRPC3/6/7	TRPC3/6/7	NNP
cord-006229-7yoilsho	2675	10	channels	channel	NNS
cord-006229-7yoilsho	2675	11	(	(	-LRB-
cord-006229-7yoilsho	2675	12	GSK1702934A	gsk1702934a	CD
cord-006229-7yoilsho	2675	13	)	)	-RRB-
cord-006229-7yoilsho	2675	14	activated	activate	VBN
cord-006229-7yoilsho	2675	15	wild	wild	JJ
cord-006229-7yoilsho	2675	16	-	-	HYPH
cord-006229-7yoilsho	2675	17	type	type	NN
cord-006229-7yoilsho	2675	18	TRPC3	TRPC3	NNS
cord-006229-7yoilsho	2675	19	and	and	CC
cord-006229-7yoilsho	2675	20	TRPC6	TRPC6	NNP
cord-006229-7yoilsho	2675	21	channels	channel	NNS
cord-006229-7yoilsho	2675	22	as	as	RB
cord-006229-7yoilsho	2675	23	well	well	RB
cord-006229-7yoilsho	2675	24	as	as	IN
cord-006229-7yoilsho	2675	25	the	the	DT
cord-006229-7yoilsho	2675	26	respective	respective	JJ
cord-006229-7yoilsho	2675	27	lipid	lipid	NN
cord-006229-7yoilsho	2675	28	insensitive	insensitive	JJ
cord-006229-7yoilsho	2675	29	mutants	mutant	NNS
cord-006229-7yoilsho	2675	30	(	(	-LRB-
cord-006229-7yoilsho	2675	31	TRPC3	trpc3	XX
cord-006229-7yoilsho	2675	32	G652A	G652A	NNP
cord-006229-7yoilsho	2675	33	,	,	,
cord-006229-7yoilsho	2675	34	TRPC6	TRPC6	NNP
cord-006229-7yoilsho	2675	35	G709A	G709A	NNP
cord-006229-7yoilsho	2675	36	)	)	-RRB-
cord-006229-7yoilsho	2675	37	.	.	.
cord-006229-7yoilsho	2676	1	Interestingly	interestingly	RB
cord-006229-7yoilsho	2676	2	,	,	,
cord-006229-7yoilsho	2676	3	the	the	DT
cord-006229-7yoilsho	2676	4	synthetic	synthetic	JJ
cord-006229-7yoilsho	2676	5	activator	activator	NN
cord-006229-7yoilsho	2676	6	was	be	VBD
cord-006229-7yoilsho	2676	7	found	find	VBN
cord-006229-7yoilsho	2676	8	to	to	TO
cord-006229-7yoilsho	2676	9	generate	generate	VB
cord-006229-7yoilsho	2676	10	substantially	substantially	RB
cord-006229-7yoilsho	2676	11	enhanced	enhance	VBN
cord-006229-7yoilsho	2676	12	TRPC	TRPC	NNP
cord-006229-7yoilsho	2676	13	conductances	conductance	NNS
cord-006229-7yoilsho	2676	14	in	in	IN
cord-006229-7yoilsho	2676	15	cells	cell	NNS
cord-006229-7yoilsho	2676	16	expressing	express	VBG
cord-006229-7yoilsho	2676	17	the	the	DT
cord-006229-7yoilsho	2676	18	lipid	lipid	NN
cord-006229-7yoilsho	2676	19	-	-	HYPH
cord-006229-7yoilsho	2676	20	insensitive	insensitive	JJ
cord-006229-7yoilsho	2676	21	mutants	mutant	NNS
cord-006229-7yoilsho	2676	22	as	as	IN
cord-006229-7yoilsho	2676	23	compared	compare	VBN
cord-006229-7yoilsho	2676	24	to	to	IN
cord-006229-7yoilsho	2676	25	wild	wild	JJ
cord-006229-7yoilsho	2676	26	-	-	HYPH
cord-006229-7yoilsho	2676	27	type	type	NN
cord-006229-7yoilsho	2676	28	proteins	protein	NNS
cord-006229-7yoilsho	2676	29	.	.	.
cord-006229-7yoilsho	2677	1	Closer	close	JJR
cord-006229-7yoilsho	2677	2	inspection	inspection	NN
cord-006229-7yoilsho	2677	3	of	of	IN
cord-006229-7yoilsho	2677	4	sensitivity	sensitivity	NN
cord-006229-7yoilsho	2677	5	of	of	IN
cord-006229-7yoilsho	2677	6	the	the	DT
cord-006229-7yoilsho	2677	7	WT	WT	NNP
cord-006229-7yoilsho	2677	8	and	and	CC
cord-006229-7yoilsho	2677	9	mutant	mutant	JJ
cord-006229-7yoilsho	2677	10	proteins	protein	NNS
cord-006229-7yoilsho	2677	11	to	to	IN
cord-006229-7yoilsho	2677	12	various	various	JJ
cord-006229-7yoilsho	2677	13	GSK	GSK	NNP
cord-006229-7yoilsho	2677	14	derivatives	derivative	NNS
cord-006229-7yoilsho	2677	15	argue	argue	VBP
cord-006229-7yoilsho	2677	16	against	against	IN
cord-006229-7yoilsho	2677	17	a	a	DT
cord-006229-7yoilsho	2677	18	contribution	contribution	NN
cord-006229-7yoilsho	2677	19	of	of	IN
cord-006229-7yoilsho	2677	20	G652	G652	NNPS
cord-006229-7yoilsho	2677	21	to	to	IN
cord-006229-7yoilsho	2677	22	GSK	GSK	NNP
cord-006229-7yoilsho	2677	23	recognition	recognition	NN
cord-006229-7yoilsho	2677	24	by	by	IN
cord-006229-7yoilsho	2677	25	TRPC3	TRPC3	NNS
cord-006229-7yoilsho	2677	26	.	.	.
cord-006229-7yoilsho	2678	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	2678	2	results	result	NNS
cord-006229-7yoilsho	2678	3	demonstrate	demonstrate	VBP
cord-006229-7yoilsho	2678	4	the	the	DT
cord-006229-7yoilsho	2678	5	existence	existence	NN
cord-006229-7yoilsho	2678	6	of	of	IN
cord-006229-7yoilsho	2678	7	two	two	CD
cord-006229-7yoilsho	2678	8	different	different	JJ
cord-006229-7yoilsho	2678	9	mechanisms	mechanism	NNS
cord-006229-7yoilsho	2678	10	of	of	IN
cord-006229-7yoilsho	2678	11	TRPC3/6	TRPC3/6	NNP
cord-006229-7yoilsho	2678	12	activation	activation	NN
cord-006229-7yoilsho	2678	13	supposedly	supposedly	RB
cord-006229-7yoilsho	2678	14	involving	involve	VBG
cord-006229-7yoilsho	2678	15	distinct	distinct	JJ
cord-006229-7yoilsho	2678	16	gating	gate	VBG
cord-006229-7yoilsho	2678	17	movements	movement	NNS
cord-006229-7yoilsho	2678	18	in	in	IN
cord-006229-7yoilsho	2678	19	the	the	DT
cord-006229-7yoilsho	2678	20	channel	channel	NN
cord-006229-7yoilsho	2678	21	complex	complex	NN
cord-006229-7yoilsho	2678	22	.	.	.
cord-006229-7yoilsho	2679	1	We	-PRON-	PRP
cord-006229-7yoilsho	2679	2	suggest	suggest	VBP
cord-006229-7yoilsho	2679	3	that	that	IN
cord-006229-7yoilsho	2679	4	lipid	lipid	NN
cord-006229-7yoilsho	2679	5	gating	gating	NN
cord-006229-7yoilsho	2679	6	of	of	IN
cord-006229-7yoilsho	2679	7	TRPC3/6	TRPC3/6	NNP
cord-006229-7yoilsho	2679	8	involves	involve	VBZ
cord-006229-7yoilsho	2679	9	a	a	DT
cord-006229-7yoilsho	2679	10	hinge	hinge	NN
cord-006229-7yoilsho	2679	11	-	-	HYPH
cord-006229-7yoilsho	2679	12	point	point	NN
cord-006229-7yoilsho	2679	13	and/or	and/or	CC
cord-006229-7yoilsho	2679	14	requires	require	VBZ
cord-006229-7yoilsho	2679	15	a	a	DT
cord-006229-7yoilsho	2679	16	certain	certain	JJ
cord-006229-7yoilsho	2679	17	level	level	NN
cord-006229-7yoilsho	2679	18	of	of	IN
cord-006229-7yoilsho	2679	19	flexibility	flexibility	NN
cord-006229-7yoilsho	2679	20	within	within	IN
cord-006229-7yoilsho	2679	21	transmembrane	transmembrane	NN
cord-006229-7yoilsho	2679	22	segment	segment	NN
cord-006229-7yoilsho	2679	23	S6	S6	NNP
cord-006229-7yoilsho	2679	24	provided	provide	VBN
cord-006229-7yoilsho	2679	25	by	by	IN
cord-006229-7yoilsho	2679	26	G652	G652	NNPS
cord-006229-7yoilsho	2679	27	.	.	.
cord-006229-7yoilsho	2680	1	Lipids	lipid	NNS
cord-006229-7yoilsho	2680	2	and	and	CC
cord-006229-7yoilsho	2680	3	synthetic	synthetic	JJ
cord-006229-7yoilsho	2680	4	activators	activator	NNS
cord-006229-7yoilsho	2680	5	of	of	IN
cord-006229-7yoilsho	2680	6	TRPC3/6	TRPC3/6	NNP
cord-006229-7yoilsho	2680	7	may	may	MD
cord-006229-7yoilsho	2680	8	be	be	VB
cord-006229-7yoilsho	2680	9	capable	capable	JJ
cord-006229-7yoilsho	2680	10	of	of	IN
cord-006229-7yoilsho	2680	11	initiating	initiate	VBG
cord-006229-7yoilsho	2680	12	markedly	markedly	RB
cord-006229-7yoilsho	2680	13	different	different	JJ
cord-006229-7yoilsho	2680	14	structural	structural	JJ
cord-006229-7yoilsho	2680	15	rearrangement	rearrangement	NN
cord-006229-7yoilsho	2680	16	in	in	IN
cord-006229-7yoilsho	2680	17	these	these	DT
cord-006229-7yoilsho	2680	18	channels	channel	NNS
cord-006229-7yoilsho	2680	19	.	.	.
cord-006229-7yoilsho	2681	1	Objective	objective	NN
cord-006229-7yoilsho	2681	2	:	:	:
cord-006229-7yoilsho	2682	1	Organophosphorus	Organophosphorus	NNP
cord-006229-7yoilsho	2682	2	compounds	compound	NNS
cord-006229-7yoilsho	2682	3	(	(	-LRB-
cord-006229-7yoilsho	2682	4	OPCs	OPCs	NNP
cord-006229-7yoilsho	2682	5	)	)	-RRB-
cord-006229-7yoilsho	2682	6	,	,	,
cord-006229-7yoilsho	2682	7	i.e.	i.e.	FW
cord-006229-7yoilsho	2682	8	nerve	nerve	JJ
cord-006229-7yoilsho	2682	9	agents	agent	NNS
cord-006229-7yoilsho	2682	10	or	or	CC
cord-006229-7yoilsho	2682	11	pesticides	pesticide	NNS
cord-006229-7yoilsho	2682	12	,	,	,
cord-006229-7yoilsho	2682	13	are	be	VBP
cord-006229-7yoilsho	2682	14	highly	highly	RB
cord-006229-7yoilsho	2682	15	toxic	toxic	JJ
cord-006229-7yoilsho	2682	16	due	due	IN
cord-006229-7yoilsho	2682	17	to	to	IN
cord-006229-7yoilsho	2682	18	their	-PRON-	PRP$
cord-006229-7yoilsho	2682	19	strong	strong	JJ
cord-006229-7yoilsho	2682	20	inhibition	inhibition	NN
cord-006229-7yoilsho	2682	21	potency	potency	NN
cord-006229-7yoilsho	2682	22	against	against	IN
cord-006229-7yoilsho	2682	23	acetylcholinesterase	acetylcholinesterase	NN
cord-006229-7yoilsho	2682	24	(	(	-LRB-
cord-006229-7yoilsho	2682	25	AChE	ache	NN
cord-006229-7yoilsho	2682	26	)	)	-RRB-
cord-006229-7yoilsho	2682	27	.	.	.
cord-006229-7yoilsho	2683	1	Inhibited	inhibited	JJ
cord-006229-7yoilsho	2683	2	AChE	ache	NN
cord-006229-7yoilsho	2683	3	results	result	NNS
cord-006229-7yoilsho	2683	4	in	in	IN
cord-006229-7yoilsho	2683	5	accumulation	accumulation	NN
cord-006229-7yoilsho	2683	6	of	of	IN
cord-006229-7yoilsho	2683	7	acetylcholine	acetylcholine	NN
cord-006229-7yoilsho	2683	8	in	in	IN
cord-006229-7yoilsho	2683	9	the	the	DT
cord-006229-7yoilsho	2683	10	synaptic	synaptic	JJ
cord-006229-7yoilsho	2683	11	cleft	cleft	NN
cord-006229-7yoilsho	2683	12	and	and	CC
cord-006229-7yoilsho	2683	13	thus	thus	RB
cord-006229-7yoilsho	2683	14	the	the	DT
cord-006229-7yoilsho	2683	15	desensitisation	desensitisation	NN
cord-006229-7yoilsho	2683	16	of	of	IN
cord-006229-7yoilsho	2683	17	the	the	DT
cord-006229-7yoilsho	2683	18	nicotinic	nicotinic	JJ
cord-006229-7yoilsho	2683	19	acetylcholine	acetylcholine	NN
cord-006229-7yoilsho	2683	20	receptor	receptor	NN
cord-006229-7yoilsho	2683	21	(	(	-LRB-
cord-006229-7yoilsho	2683	22	nAChR	nAChR	NNP
cord-006229-7yoilsho	2683	23	)	)	-RRB-
cord-006229-7yoilsho	2683	24	in	in	IN
cord-006229-7yoilsho	2683	25	the	the	DT
cord-006229-7yoilsho	2683	26	postsynaptic	postsynaptic	JJ
cord-006229-7yoilsho	2683	27	membrane	membrane	NN
cord-006229-7yoilsho	2683	28	is	be	VBZ
cord-006229-7yoilsho	2683	29	provoked	provoke	VBN
cord-006229-7yoilsho	2683	30	.	.	.
cord-006229-7yoilsho	2684	1	As	as	IN
cord-006229-7yoilsho	2684	2	the	the	DT
cord-006229-7yoilsho	2684	3	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	2684	4	efficacy	efficacy	NN
cord-006229-7yoilsho	2684	5	of	of	IN
cord-006229-7yoilsho	2684	6	oximes	oxime	NNS
cord-006229-7yoilsho	2684	7	is	be	VBZ
cord-006229-7yoilsho	2684	8	limited	limit	VBN
cord-006229-7yoilsho	2684	9	,	,	,
cord-006229-7yoilsho	2684	10	e.g.	e.g.	RB
cord-006229-7yoilsho	2684	11	poisoning	poisoning	NN
cord-006229-7yoilsho	2684	12	by	by	IN
cord-006229-7yoilsho	2684	13	soman	soman	NNP
cord-006229-7yoilsho	2684	14	or	or	CC
cord-006229-7yoilsho	2684	15	tabun	tabun	NNP
cord-006229-7yoilsho	2684	16	,	,	,
cord-006229-7yoilsho	2684	17	the	the	DT
cord-006229-7yoilsho	2684	18	direct	direct	JJ
cord-006229-7yoilsho	2684	19	targeting	targeting	NN
cord-006229-7yoilsho	2684	20	of	of	IN
cord-006229-7yoilsho	2684	21	nAChR	nAChR	NNP
cord-006229-7yoilsho	2684	22	may	may	MD
cord-006229-7yoilsho	2684	23	be	be	VB
cord-006229-7yoilsho	2684	24	an	an	DT
cord-006229-7yoilsho	2684	25	alternative	alternative	JJ
cord-006229-7yoilsho	2684	26	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	2684	27	approach	approach	NN
cord-006229-7yoilsho	2684	28	.	.	.
cord-006229-7yoilsho	2685	1	Studies	study	NNS
cord-006229-7yoilsho	2685	2	with	with	IN
cord-006229-7yoilsho	2685	3	the	the	DT
cord-006229-7yoilsho	2685	4	non	non	JJ
cord-006229-7yoilsho	2685	5	-	-	JJ
cord-006229-7yoilsho	2685	6	oxime	oxime	JJ
cord-006229-7yoilsho	2685	7	bispyridinium	bispyridinium	NN
cord-006229-7yoilsho	2685	8	compound	compound	NN
cord-006229-7yoilsho	2685	9	(	(	-LRB-
cord-006229-7yoilsho	2685	10	BP	BP	NNP
cord-006229-7yoilsho	2685	11	)	)	-RRB-
cord-006229-7yoilsho	2686	1	MB327	mb327	NN
cord-006229-7yoilsho	2687	1	(	(	-LRB-
cord-006229-7yoilsho	2687	2	1,1'-(propane-1,3-diyl	1,1'-(propane-1,3-diyl	LS
cord-006229-7yoilsho	2687	3	)	)	-RRB-
cord-006229-7yoilsho	2687	4	bis	bis	NNP
cord-006229-7yoilsho	2687	5	(	(	-LRB-
cord-006229-7yoilsho	2687	6	4-tert	4-tert	CD
cord-006229-7yoilsho	2687	7	-	-	HYPH
cord-006229-7yoilsho	2687	8	butylpyridinium	butylpyridinium	NN
cord-006229-7yoilsho	2687	9	)	)	-RRB-
cord-006229-7yoilsho	2687	10	di(iodide	di(iodide	NN
cord-006229-7yoilsho	2687	11	)	)	-RRB-
cord-006229-7yoilsho	2687	12	)	)	-RRB-
cord-006229-7yoilsho	2687	13	demonstrated	demonstrate	VBD
cord-006229-7yoilsho	2687	14	a	a	DT
cord-006229-7yoilsho	2687	15	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	2687	16	effect	effect	NN
cord-006229-7yoilsho	2687	17	against	against	IN
cord-006229-7yoilsho	2687	18	soman	soman	NNP
cord-006229-7yoilsho	2687	19	in	in	IN
cord-006229-7yoilsho	2687	20	vitro	vitro	FW
cord-006229-7yoilsho	2687	21	and	and	CC
cord-006229-7yoilsho	2687	22	in	in	IN
cord-006229-7yoilsho	2687	23	vivo	vivo	NNP
cord-006229-7yoilsho	2687	24	.	.	.
cord-006229-7yoilsho	2688	1	Consequently	consequently	RB
cord-006229-7yoilsho	2688	2	,	,	,
cord-006229-7yoilsho	2688	3	studying	study	VBG
cord-006229-7yoilsho	2688	4	the	the	DT
cord-006229-7yoilsho	2688	5	affinity	affinity	NN
cord-006229-7yoilsho	2688	6	of	of	IN
cord-006229-7yoilsho	2688	7	BPs	bp	NNS
cord-006229-7yoilsho	2688	8	at	at	IN
cord-006229-7yoilsho	2688	9	muscle	muscle	NN
cord-006229-7yoilsho	2688	10	-	-	HYPH
cord-006229-7yoilsho	2688	11	type	type	NN
cord-006229-7yoilsho	2688	12	nAChRs	nachrs	NN
cord-006229-7yoilsho	2688	13	and	and	CC
cord-006229-7yoilsho	2688	14	functional	functional	JJ
cord-006229-7yoilsho	2688	15	effects	effect	NNS
cord-006229-7yoilsho	2688	16	are	be	VBP
cord-006229-7yoilsho	2688	17	topics	topic	NNS
cord-006229-7yoilsho	2688	18	of	of	IN
cord-006229-7yoilsho	2688	19	interest	interest	NN
cord-006229-7yoilsho	2688	20	.	.	.
cord-006229-7yoilsho	2689	1	To	to	TO
cord-006229-7yoilsho	2689	2	identify	identify	VB
cord-006229-7yoilsho	2689	3	potential	potential	JJ
cord-006229-7yoilsho	2689	4	candidates	candidate	NNS
cord-006229-7yoilsho	2689	5	,	,	,
cord-006229-7yoilsho	2689	6	homologous	homologous	JJ
cord-006229-7yoilsho	2689	7	series	series	NN
cord-006229-7yoilsho	2689	8	of	of	IN
cord-006229-7yoilsho	2689	9	substituted	substituted	JJ
cord-006229-7yoilsho	2689	10	and	and	CC
cord-006229-7yoilsho	2689	11	non	non	JJ
cord-006229-7yoilsho	2689	12	-	-	JJ
cord-006229-7yoilsho	2689	13	substituted	substitute	VBN
cord-006229-7yoilsho	2689	14	analogues	analogue	NNS
cord-006229-7yoilsho	2689	15	(	(	-LRB-
cord-006229-7yoilsho	2689	16	linker	linker	NN
cord-006229-7yoilsho	2689	17	C	C	NNP
cord-006229-7yoilsho	2689	18	1	1	CD
cord-006229-7yoilsho	2689	19	-C	-C	VBZ
cord-006229-7yoilsho	2689	20	10	10	CD
cord-006229-7yoilsho	2689	21	)	)	-RRB-
cord-006229-7yoilsho	2689	22	of	of	IN
cord-006229-7yoilsho	2689	23	MB327	mb327	NN
cord-006229-7yoilsho	2689	24	were	be	VBD
cord-006229-7yoilsho	2689	25	investigated	investigate	VBN
cord-006229-7yoilsho	2689	26	by	by	IN
cord-006229-7yoilsho	2689	27	using	use	VBG
cord-006229-7yoilsho	2689	28	binding	bind	VBG
cord-006229-7yoilsho	2689	29	and	and	CC
cord-006229-7yoilsho	2689	30	functional	functional	JJ
cord-006229-7yoilsho	2689	31	assays	assay	NNS
cord-006229-7yoilsho	2689	32	.	.	.
cord-006229-7yoilsho	2690	1	Experimental	experimental	JJ
cord-006229-7yoilsho	2690	2	procedures	procedure	NNS
cord-006229-7yoilsho	2690	3	:	:	:
cord-006229-7yoilsho	2691	1	Crude	crude	JJ
cord-006229-7yoilsho	2691	2	membranes	membrane	NNS
cord-006229-7yoilsho	2691	3	from	from	IN
cord-006229-7yoilsho	2691	4	frozen	frozen	JJ
cord-006229-7yoilsho	2691	5	electric	electric	JJ
cord-006229-7yoilsho	2691	6	organ	organ	NN
cord-006229-7yoilsho	2691	7	of	of	IN
cord-006229-7yoilsho	2691	8	Torpedo	Torpedo	NNP
cord-006229-7yoilsho	2691	9	californica	californica	NN
cord-006229-7yoilsho	2691	10	were	be	VBD
cord-006229-7yoilsho	2691	11	purified	purify	VBN
cord-006229-7yoilsho	2691	12	by	by	IN
cord-006229-7yoilsho	2691	13	sucrose	sucrose	NN
cord-006229-7yoilsho	2691	14	-	-	HYPH
cord-006229-7yoilsho	2691	15	gradient	gradient	NN
cord-006229-7yoilsho	2691	16	density	density	NN
cord-006229-7yoilsho	2691	17	centrifugation	centrifugation	NN
cord-006229-7yoilsho	2691	18	and	and	CC
cord-006229-7yoilsho	2691	19	used	use	VBN
cord-006229-7yoilsho	2691	20	in	in	IN
cord-006229-7yoilsho	2691	21	both	both	CC
cord-006229-7yoilsho	2691	22	affinity	affinity	NN
cord-006229-7yoilsho	2691	23	and	and	CC
cord-006229-7yoilsho	2691	24	functional	functional	JJ
cord-006229-7yoilsho	2691	25	assays	assay	NNS
cord-006229-7yoilsho	2691	26	.	.	.
cord-006229-7yoilsho	2692	1	In	in	IN
cord-006229-7yoilsho	2692	2	competition	competition	NN
cord-006229-7yoilsho	2692	3	radio	radio	NN
cord-006229-7yoilsho	2692	4	-	-	HYPH
cord-006229-7yoilsho	2692	5	ligand	ligand	NN
cord-006229-7yoilsho	2692	6	binding	binding	NN
cord-006229-7yoilsho	2692	7	assays	assay	NNS
cord-006229-7yoilsho	2692	8	,	,	,
cord-006229-7yoilsho	2692	9	the	the	DT
cord-006229-7yoilsho	2692	10	influence	influence	NN
cord-006229-7yoilsho	2692	11	on	on	IN
cord-006229-7yoilsho	2692	12	[	[	-LRB-
cord-006229-7yoilsho	2692	13	³H]epibatidine	³h]epibatidine	NN
cord-006229-7yoilsho	2692	14	binding	bind	VBG
cord-006229-7yoilsho	2692	15	sites	site	NNS
cord-006229-7yoilsho	2692	16	of	of	IN
cord-006229-7yoilsho	2692	17	Torpedo	torpedo	NN
cord-006229-7yoilsho	2692	18	muscle	muscle	NN
cord-006229-7yoilsho	2692	19	-	-	HYPH
cord-006229-7yoilsho	2692	20	type	type	NN
cord-006229-7yoilsho	2692	21	nAChR	nAChR	NNP
cord-006229-7yoilsho	2692	22	was	be	VBD
cord-006229-7yoilsho	2692	23	determined	determine	VBN
cord-006229-7yoilsho	2692	24	.	.	.
cord-006229-7yoilsho	2693	1	Functional	functional	JJ
cord-006229-7yoilsho	2693	2	assessments	assessment	NNS
cord-006229-7yoilsho	2693	3	were	be	VBD
cord-006229-7yoilsho	2693	4	carried	carry	VBN
cord-006229-7yoilsho	2693	5	out	out	RP
cord-006229-7yoilsho	2693	6	with	with	IN
cord-006229-7yoilsho	2693	7	a	a	DT
cord-006229-7yoilsho	2693	8	bilayer	bilayer	NN
cord-006229-7yoilsho	2693	9	method	method	NN
cord-006229-7yoilsho	2693	10	to	to	TO
cord-006229-7yoilsho	2693	11	investigate	investigate	VB
cord-006229-7yoilsho	2693	12	the	the	DT
cord-006229-7yoilsho	2693	13	effect	effect	NN
cord-006229-7yoilsho	2693	14	on	on	IN
cord-006229-7yoilsho	2693	15	the	the	DT
cord-006229-7yoilsho	2693	16	cholinergic	cholinergic	JJ
cord-006229-7yoilsho	2693	17	signal	signal	NN
cord-006229-7yoilsho	2693	18	induced	induce	VBN
cord-006229-7yoilsho	2693	19	by	by	IN
cord-006229-7yoilsho	2693	20	100	100	CD
cord-006229-7yoilsho	2693	21	µM	µM	NNP
cord-006229-7yoilsho	2693	22	carbamoylcholine	carbamoylcholine	NN
cord-006229-7yoilsho	2693	23	.	.	.
cord-006229-7yoilsho	2694	1	Results	result	NNS
cord-006229-7yoilsho	2694	2	:	:	:
cord-006229-7yoilsho	2695	1	Bispyridinium	Bispyridinium	NNP
cord-006229-7yoilsho	2695	2	compounds	compound	NNS
cord-006229-7yoilsho	2695	3	bearing	bear	VBG
cord-006229-7yoilsho	2695	4	unsubstituted	unsubstitute	VBN
cord-006229-7yoilsho	2695	5	pyridinium	pyridinium	NN
cord-006229-7yoilsho	2695	6	rings	ring	NNS
cord-006229-7yoilsho	2695	7	and	and	CC
cord-006229-7yoilsho	2695	8	long	long	JJ
cord-006229-7yoilsho	2695	9	alkyl	alkyl	NN
cord-006229-7yoilsho	2695	10	linkers	linker	NNS
cord-006229-7yoilsho	2695	11	(	(	-LRB-
cord-006229-7yoilsho	2695	12	>	>	XX
cord-006229-7yoilsho	2696	1	C	C	NNP
cord-006229-7yoilsho	2696	2	7	7	CD
cord-006229-7yoilsho	2696	3	)	)	-RRB-
cord-006229-7yoilsho	2696	4	inhibited	inhibit	VBD
cord-006229-7yoilsho	2696	5	the	the	DT
cord-006229-7yoilsho	2696	6	binding	binding	NN
cord-006229-7yoilsho	2696	7	of	of	IN
cord-006229-7yoilsho	2696	8	[	[	-LRB-
cord-006229-7yoilsho	2696	9	³H]epibatidine	³H]epibatidine	NNP
cord-006229-7yoilsho	2696	10	and	and	CC
cord-006229-7yoilsho	2696	11	decreased	decrease	VBD
cord-006229-7yoilsho	2696	12	the	the	DT
cord-006229-7yoilsho	2696	13	cholinergic	cholinergic	JJ
cord-006229-7yoilsho	2696	14	signal	signal	NN
cord-006229-7yoilsho	2696	15	of	of	IN
cord-006229-7yoilsho	2696	16	100	100	CD
cord-006229-7yoilsho	2696	17	µM	µm	CD
cord-006229-7yoilsho	2696	18	carbamoylcholine	carbamoylcholine	NN
cord-006229-7yoilsho	2696	19	in	in	IN
cord-006229-7yoilsho	2696	20	the	the	DT
cord-006229-7yoilsho	2696	21	functional	functional	JJ
cord-006229-7yoilsho	2696	22	assay	assay	NN
cord-006229-7yoilsho	2696	23	.	.	.
cord-006229-7yoilsho	2697	1	MB327	mb327	NN
cord-006229-7yoilsho	2697	2	and	and	CC
cord-006229-7yoilsho	2697	3	several	several	JJ
cord-006229-7yoilsho	2697	4	bispyridinium	bispyridinium	NN
cord-006229-7yoilsho	2697	5	structure	structure	NN
cord-006229-7yoilsho	2697	6	analogues	analogue	NNS
cord-006229-7yoilsho	2697	7	(	(	-LRB-
cord-006229-7yoilsho	2697	8	mainly	mainly	RB
cord-006229-7yoilsho	2697	9	C	C	NNP
cord-006229-7yoilsho	2697	10	2	2	CD
cord-006229-7yoilsho	2697	11	-C	-C	VBZ
cord-006229-7yoilsho	2697	12	4	4	CD
cord-006229-7yoilsho	2697	13	linker	linker	NN
cord-006229-7yoilsho	2697	14	)	)	-RRB-
cord-006229-7yoilsho	2697	15	exhibited	exhibit	VBD
cord-006229-7yoilsho	2697	16	no	no	DT
cord-006229-7yoilsho	2697	17	regular	regular	JJ
cord-006229-7yoilsho	2697	18	displacement	displacement	NN
cord-006229-7yoilsho	2697	19	curves	curve	NNS
cord-006229-7yoilsho	2697	20	at	at	IN
cord-006229-7yoilsho	2697	21	[	[	-LRB-
cord-006229-7yoilsho	2697	22	3	3	CD
cord-006229-7yoilsho	2697	23	H]epibatidine	H]epibatidine	NNP
cord-006229-7yoilsho	2697	24	binding	bind	VBG
cord-006229-7yoilsho	2697	25	sites	site	NNS
cord-006229-7yoilsho	2697	26	and	and	CC
cord-006229-7yoilsho	2697	27	enhanced	enhance	VBD
cord-006229-7yoilsho	2697	28	the	the	DT
cord-006229-7yoilsho	2697	29	carbamoylcholine	carbamoylcholine	NN
cord-006229-7yoilsho	2697	30	-	-	HYPH
cord-006229-7yoilsho	2697	31	induced	induce	VBN
cord-006229-7yoilsho	2697	32	signal	signal	NN
cord-006229-7yoilsho	2697	33	.	.	.
cord-006229-7yoilsho	2698	1	The	the	DT
cord-006229-7yoilsho	2698	2	results	result	NNS
cord-006229-7yoilsho	2698	3	demonstrate	demonstrate	VBP
cord-006229-7yoilsho	2698	4	that	that	IN
cord-006229-7yoilsho	2698	5	the	the	DT
cord-006229-7yoilsho	2698	6	described	describe	VBN
cord-006229-7yoilsho	2698	7	affinity	affinity	NN
cord-006229-7yoilsho	2698	8	and	and	CC
cord-006229-7yoilsho	2698	9	functional	functional	JJ
cord-006229-7yoilsho	2698	10	screening	screening	NN
cord-006229-7yoilsho	2698	11	methods	method	NNS
cord-006229-7yoilsho	2698	12	detected	detect	VBD
cord-006229-7yoilsho	2698	13	some	some	DT
cord-006229-7yoilsho	2698	14	structure	structure	NN
cord-006229-7yoilsho	2698	15	-	-	HYPH
cord-006229-7yoilsho	2698	16	activity	activity	NN
cord-006229-7yoilsho	2698	17	-	-	HYPH
cord-006229-7yoilsho	2698	18	relationships	relationship	NNS
cord-006229-7yoilsho	2698	19	(	(	-LRB-
cord-006229-7yoilsho	2698	20	SAR	SAR	NNP
cord-006229-7yoilsho	2698	21	)	)	-RRB-
cord-006229-7yoilsho	2698	22	.	.	.
cord-006229-7yoilsho	2699	1	Depending	depend	VBG
cord-006229-7yoilsho	2699	2	on	on	IN
cord-006229-7yoilsho	2699	3	linker	linker	NN
cord-006229-7yoilsho	2699	4	length	length	NN
cord-006229-7yoilsho	2699	5	and	and	CC
cord-006229-7yoilsho	2699	6	substitution	substitution	NN
cord-006229-7yoilsho	2699	7	pattern	pattern	NN
cord-006229-7yoilsho	2699	8	,	,	,
cord-006229-7yoilsho	2699	9	the	the	DT
cord-006229-7yoilsho	2699	10	investigated	investigate	VBN
cord-006229-7yoilsho	2699	11	bispyridinium	bispyridinium	NN
cord-006229-7yoilsho	2699	12	compounds	compound	NNS
cord-006229-7yoilsho	2699	13	seemed	seem	VBD
cord-006229-7yoilsho	2699	14	to	to	TO
cord-006229-7yoilsho	2699	15	interact	interact	VB
cord-006229-7yoilsho	2699	16	as	as	IN
cord-006229-7yoilsho	2699	17	positive	positive	JJ
cord-006229-7yoilsho	2699	18	allosteric	allosteric	JJ
cord-006229-7yoilsho	2699	19	modulators	modulator	NNS
cord-006229-7yoilsho	2699	20	.	.	.
cord-006229-7yoilsho	2700	1	Further	further	JJ
cord-006229-7yoilsho	2700	2	research	research	NN
cord-006229-7yoilsho	2700	3	is	be	VBZ
cord-006229-7yoilsho	2700	4	necessary	necessary	JJ
cord-006229-7yoilsho	2700	5	to	to	TO
cord-006229-7yoilsho	2700	6	verify	verify	VB
cord-006229-7yoilsho	2700	7	this	this	DT
cord-006229-7yoilsho	2700	8	hypothesis	hypothesis	NN
cord-006229-7yoilsho	2700	9	.	.	.
cord-006229-7yoilsho	2701	1	Non	non	JJ
cord-006229-7yoilsho	2701	2	oxime	oxime	NN
cord-006229-7yoilsho	2701	3	bispyridinium	bispyridinium	NN
cord-006229-7yoilsho	2701	4	compounds	compound	NNS
cord-006229-7yoilsho	2701	5	with	with	IN
cord-006229-7yoilsho	2701	6	an	an	DT
cord-006229-7yoilsho	2701	7	effect	effect	NN
cord-006229-7yoilsho	2701	8	on	on	IN
cord-006229-7yoilsho	2701	9	soman	soman	NNP
cord-006229-7yoilsho	2701	10	-	-	HYPH
cord-006229-7yoilsho	2701	11	blocked	block	VBN
cord-006229-7yoilsho	2701	12	respiratory	respiratory	JJ
cord-006229-7yoilsho	2701	13	muscle	muscle	NN
cord-006229-7yoilsho	2701	14	function	function	NN
cord-006229-7yoilsho	2701	15	have	have	VBP
cord-006229-7yoilsho	2701	16	no	no	DT
cord-006229-7yoilsho	2701	17	effect	effect	NN
cord-006229-7yoilsho	2701	18	on	on	IN
cord-006229-7yoilsho	2701	19	normal	normal	JJ
cord-006229-7yoilsho	2701	20	muscle	muscle	NN
cord-006229-7yoilsho	2701	21	function	function	NN
cord-006229-7yoilsho	2702	1	The	the	DT
cord-006229-7yoilsho	2702	2	life	life	NN
cord-006229-7yoilsho	2702	3	threatening	threaten	VBG
cord-006229-7yoilsho	2702	4	toxicity	toxicity	NN
cord-006229-7yoilsho	2702	5	of	of	IN
cord-006229-7yoilsho	2702	6	organophosphorus	organophosphorus	JJ
cord-006229-7yoilsho	2702	7	compounds	compound	NNS
cord-006229-7yoilsho	2702	8	(	(	-LRB-
cord-006229-7yoilsho	2702	9	OP	OP	NNP
cord-006229-7yoilsho	2702	10	)	)	-RRB-
cord-006229-7yoilsho	2702	11	,	,	,
cord-006229-7yoilsho	2702	12	like	like	IN
cord-006229-7yoilsho	2702	13	nerve	nerve	NN
cord-006229-7yoilsho	2702	14	agents	agent	NNS
cord-006229-7yoilsho	2702	15	or	or	CC
cord-006229-7yoilsho	2702	16	pesticides	pesticide	NNS
cord-006229-7yoilsho	2702	17	,	,	,
cord-006229-7yoilsho	2702	18	lies	lie	VBZ
cord-006229-7yoilsho	2702	19	in	in	IN
cord-006229-7yoilsho	2702	20	the	the	DT
cord-006229-7yoilsho	2702	21	inhibition	inhibition	NN
cord-006229-7yoilsho	2702	22	of	of	IN
cord-006229-7yoilsho	2702	23	acetylcholinesterase	acetylcholinesterase	NN
cord-006229-7yoilsho	2702	24	(	(	-LRB-
cord-006229-7yoilsho	2702	25	AChE	ache	NN
cord-006229-7yoilsho	2702	26	)	)	-RRB-
cord-006229-7yoilsho	2702	27	which	which	WDT
cord-006229-7yoilsho	2702	28	causes	cause	VBZ
cord-006229-7yoilsho	2702	29	cholinergic	cholinergic	JJ
cord-006229-7yoilsho	2702	30	crisis	crisis	NN
cord-006229-7yoilsho	2702	31	.	.	.
cord-006229-7yoilsho	2703	1	The	the	DT
cord-006229-7yoilsho	2703	2	accumulated	accumulate	VBN
cord-006229-7yoilsho	2703	3	acetylcholine	acetylcholine	NN
cord-006229-7yoilsho	2703	4	in	in	IN
cord-006229-7yoilsho	2703	5	neuromuscular	neuromuscular	JJ
cord-006229-7yoilsho	2703	6	synapses	synapsis	NNS
cord-006229-7yoilsho	2703	7	results	result	NNS
cord-006229-7yoilsho	2703	8	in	in	IN
cord-006229-7yoilsho	2703	9	the	the	DT
cord-006229-7yoilsho	2703	10	desensitization	desensitization	NN
cord-006229-7yoilsho	2703	11	of	of	IN
cord-006229-7yoilsho	2703	12	nicotinic	nicotinic	JJ
cord-006229-7yoilsho	2703	13	acetylcholine	acetylcholine	NN
cord-006229-7yoilsho	2703	14	receptors	receptor	NNS
cord-006229-7yoilsho	2703	15	(	(	-LRB-
cord-006229-7yoilsho	2703	16	nAChR	nAChR	NNP
cord-006229-7yoilsho	2703	17	)	)	-RRB-
cord-006229-7yoilsho	2703	18	and	and	CC
cord-006229-7yoilsho	2703	19	paralysis	paralysis	NN
cord-006229-7yoilsho	2703	20	of	of	IN
cord-006229-7yoilsho	2703	21	respiratoric	respiratoric	JJ
cord-006229-7yoilsho	2703	22	muscles	muscle	NNS
cord-006229-7yoilsho	2703	23	.	.	.
cord-006229-7yoilsho	2704	1	The	the	DT
cord-006229-7yoilsho	2704	2	4-tert	4-tert	CD
cord-006229-7yoilsho	2704	3	-	-	HYPH
cord-006229-7yoilsho	2704	4	butyl	butyl	NN
cord-006229-7yoilsho	2704	5	-	-	HYPH
cord-006229-7yoilsho	2704	6	substituted	substitute	VBN
cord-006229-7yoilsho	2704	7	bispyridinium	bispyridinium	NN
cord-006229-7yoilsho	2704	8	compound	compound	NN
cord-006229-7yoilsho	2704	9	MB327	mb327	NN
cord-006229-7yoilsho	2704	10	showed	show	VBD
cord-006229-7yoilsho	2704	11	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	2704	12	efficacy	efficacy	NN
cord-006229-7yoilsho	2704	13	in	in	IN
cord-006229-7yoilsho	2704	14	soman	soman	NNP
cord-006229-7yoilsho	2704	15	and	and	CC
cord-006229-7yoilsho	2704	16	tabun	tabun	NNP
cord-006229-7yoilsho	2704	17	poisoned	poison	VBD
cord-006229-7yoilsho	2704	18	guinea	guinea	NN
cord-006229-7yoilsho	2704	19	pigs	pig	NNS
cord-006229-7yoilsho	2704	20	in	in	IN
cord-006229-7yoilsho	2704	21	vivo	vivo	NN
cord-006229-7yoilsho	2704	22	.	.	.
cord-006229-7yoilsho	2705	1	Partial	partial	JJ
cord-006229-7yoilsho	2705	2	restauration	restauration	NN
cord-006229-7yoilsho	2705	3	of	of	IN
cord-006229-7yoilsho	2705	4	neuromuscular	neuromuscular	JJ
cord-006229-7yoilsho	2705	5	transmission	transmission	NN
cord-006229-7yoilsho	2705	6	by	by	IN
cord-006229-7yoilsho	2705	7	bispyridinium	bispyridinium	NN
cord-006229-7yoilsho	2705	8	compounds	compound	NNS
cord-006229-7yoilsho	2705	9	(	(	-LRB-
cord-006229-7yoilsho	2705	10	BP	BP	NNP
cord-006229-7yoilsho	2705	11	)	)	-RRB-
cord-006229-7yoilsho	2705	12	,	,	.
cord-006229-7yoilsho	2706	1	e.g.	e.g.	RB
cord-006229-7yoilsho	2706	2	MB327	mb327	NN
cord-006229-7yoilsho	2706	3	or	or	CC
cord-006229-7yoilsho	2706	4	MB420	MB420	NNP
cord-006229-7yoilsho	2706	5	,	,	,
cord-006229-7yoilsho	2706	6	could	could	MD
cord-006229-7yoilsho	2706	7	also	also	RB
cord-006229-7yoilsho	2706	8	observed	observe	VBN
cord-006229-7yoilsho	2706	9	in	in	IN
cord-006229-7yoilsho	2706	10	soman	soman	NNP
cord-006229-7yoilsho	2706	11	paralysed	paralysed	JJ
cord-006229-7yoilsho	2706	12	respiratory	respiratory	JJ
cord-006229-7yoilsho	2706	13	muscles	muscle	NNS
cord-006229-7yoilsho	2706	14	in	in	IN
cord-006229-7yoilsho	2706	15	vitro	vitro	FW
cord-006229-7yoilsho	2706	16	and	and	CC
cord-006229-7yoilsho	2706	17	was	be	VBD
cord-006229-7yoilsho	2706	18	partly	partly	RB
cord-006229-7yoilsho	2706	19	attributed	attribute	VBN
cord-006229-7yoilsho	2706	20	to	to	IN
cord-006229-7yoilsho	2706	21	an	an	DT
cord-006229-7yoilsho	2706	22	interaction	interaction	NN
cord-006229-7yoilsho	2706	23	of	of	IN
cord-006229-7yoilsho	2706	24	BP	BP	NNP
cord-006229-7yoilsho	2706	25	with	with	IN
cord-006229-7yoilsho	2706	26	nAChRs	nAChRs	NNP
cord-006229-7yoilsho	2706	27	.	.	.
cord-006229-7yoilsho	2707	1	However	however	RB
cord-006229-7yoilsho	2707	2	,	,	,
cord-006229-7yoilsho	2707	3	it	-PRON-	PRP
cord-006229-7yoilsho	2707	4	is	be	VBZ
cord-006229-7yoilsho	2707	5	unknown	unknown	JJ
cord-006229-7yoilsho	2707	6	,	,	,
cord-006229-7yoilsho	2707	7	whether	whether	IN
cord-006229-7yoilsho	2707	8	these	these	DT
cord-006229-7yoilsho	2707	9	BP	BP	NNP
cord-006229-7yoilsho	2707	10	might	may	MD
cord-006229-7yoilsho	2707	11	affect	affect	VB
cord-006229-7yoilsho	2707	12	normal	normal	JJ
cord-006229-7yoilsho	2707	13	respiratory	respiratory	JJ
cord-006229-7yoilsho	2707	14	muscle	muscle	NN
cord-006229-7yoilsho	2707	15	function	function	NN
cord-006229-7yoilsho	2707	16	in	in	IN
cord-006229-7yoilsho	2707	17	the	the	DT
cord-006229-7yoilsho	2707	18	absence	absence	NN
cord-006229-7yoilsho	2707	19	of	of	IN
cord-006229-7yoilsho	2707	20	cholinergic	cholinergic	JJ
cord-006229-7yoilsho	2707	21	crisis	crisis	NN
cord-006229-7yoilsho	2707	22	.	.	.
cord-006229-7yoilsho	2708	1	Therefore	therefore	RB
cord-006229-7yoilsho	2708	2	this	this	DT
cord-006229-7yoilsho	2708	3	study	study	NN
cord-006229-7yoilsho	2708	4	investigated	investigate	VBD
cord-006229-7yoilsho	2708	5	the	the	DT
cord-006229-7yoilsho	2708	6	effect	effect	NN
cord-006229-7yoilsho	2708	7	of	of	IN
cord-006229-7yoilsho	2708	8	BP	BP	NNP
cord-006229-7yoilsho	2708	9	on	on	IN
cord-006229-7yoilsho	2708	10	physiological	physiological	JJ
cord-006229-7yoilsho	2708	11	rat	rat	NN
cord-006229-7yoilsho	2708	12	diaphragm	diaphragm	NN
cord-006229-7yoilsho	2708	13	muscle	muscle	NN
cord-006229-7yoilsho	2708	14	function	function	NN
cord-006229-7yoilsho	2708	15	.	.	.
cord-006229-7yoilsho	2709	1	Force	force	NN
cord-006229-7yoilsho	2709	2	generation	generation	NN
cord-006229-7yoilsho	2709	3	of	of	IN
cord-006229-7yoilsho	2709	4	rat	rat	NN
cord-006229-7yoilsho	2709	5	diaphragm	diaphragm	NN
cord-006229-7yoilsho	2709	6	hemispheres	hemisphere	NNS
cord-006229-7yoilsho	2709	7	was	be	VBD
cord-006229-7yoilsho	2709	8	determined	determine	VBN
cord-006229-7yoilsho	2709	9	after	after	IN
cord-006229-7yoilsho	2709	10	incubation	incubation	NN
cord-006229-7yoilsho	2709	11	with	with	IN
cord-006229-7yoilsho	2709	12	increasing	increase	VBG
cord-006229-7yoilsho	2709	13	BP	BP	NNP
cord-006229-7yoilsho	2709	14	concentrations	concentration	NNS
cord-006229-7yoilsho	2709	15	(	(	-LRB-
cord-006229-7yoilsho	2709	16	1	1	CD
cord-006229-7yoilsho	2709	17	-	-	SYM
cord-006229-7yoilsho	2709	18	300	300	CD
cord-006229-7yoilsho	2709	19	µM	µm	NN
cord-006229-7yoilsho	2709	20	)	)	-RRB-
cord-006229-7yoilsho	2709	21	and	and	CC
cord-006229-7yoilsho	2709	22	compare	compare	VB
cord-006229-7yoilsho	2709	23	to	to	IN
cord-006229-7yoilsho	2709	24	sham	sham	JJ
cord-006229-7yoilsho	2709	25	treatment	treatment	NN
cord-006229-7yoilsho	2709	26	.	.	.
cord-006229-7yoilsho	2710	1	The	the	DT
cord-006229-7yoilsho	2710	2	diaphragm	diaphragm	NN
cord-006229-7yoilsho	2710	3	hemispheres	hemisphere	NNS
cord-006229-7yoilsho	2710	4	were	be	VBD
cord-006229-7yoilsho	2710	5	stimulated	stimulate	VBN
cord-006229-7yoilsho	2710	6	every	every	DT
cord-006229-7yoilsho	2710	7	ten	ten	CD
cord-006229-7yoilsho	2710	8	minutes	minute	NNS
cord-006229-7yoilsho	2710	9	by	by	IN
cord-006229-7yoilsho	2710	10	an	an	DT
cord-006229-7yoilsho	2710	11	indirect	indirect	JJ
cord-006229-7yoilsho	2710	12	electrical	electrical	JJ
cord-006229-7yoilsho	2710	13	field	field	NN
cord-006229-7yoilsho	2710	14	(	(	-LRB-
cord-006229-7yoilsho	2710	15	20	20	CD
cord-006229-7yoilsho	2710	16	,	,	,
cord-006229-7yoilsho	2710	17	50	50	CD
cord-006229-7yoilsho	2710	18	,	,	,
cord-006229-7yoilsho	2710	19	100	100	CD
cord-006229-7yoilsho	2710	20	Hz	Hz	NNS
cord-006229-7yoilsho	2710	21	)	)	-RRB-
cord-006229-7yoilsho	2710	22	.	.	.
cord-006229-7yoilsho	2711	1	Muscle	muscle	NN
cord-006229-7yoilsho	2711	2	force	force	NN
cord-006229-7yoilsho	2711	3	was	be	VBD
cord-006229-7yoilsho	2711	4	analyzed	analyze	VBN
cord-006229-7yoilsho	2711	5	as	as	IN
cord-006229-7yoilsho	2711	6	time	time	NN
cord-006229-7yoilsho	2711	7	-	-	HYPH
cord-006229-7yoilsho	2711	8	force	force	NN
cord-006229-7yoilsho	2711	9	integral	integral	NN
cord-006229-7yoilsho	2711	10	and	and	CC
cord-006229-7yoilsho	2711	11	is	be	VBZ
cord-006229-7yoilsho	2711	12	expressed	express	VBN
cord-006229-7yoilsho	2711	13	as	as	IN
cord-006229-7yoilsho	2711	14	percentage	percentage	NN
cord-006229-7yoilsho	2711	15	of	of	IN
cord-006229-7yoilsho	2711	16	the	the	DT
cord-006229-7yoilsho	2711	17	individual	individual	JJ
cord-006229-7yoilsho	2711	18	control	control	NN
cord-006229-7yoilsho	2711	19	values	value	NNS
cord-006229-7yoilsho	2711	20	,	,	,
cord-006229-7yoilsho	2711	21	measured	measure	VBN
cord-006229-7yoilsho	2711	22	at	at	IN
cord-006229-7yoilsho	2711	23	the	the	DT
cord-006229-7yoilsho	2711	24	outset	outset	NN
cord-006229-7yoilsho	2711	25	of	of	IN
cord-006229-7yoilsho	2711	26	the	the	DT
cord-006229-7yoilsho	2711	27	experiment	experiment	NN
cord-006229-7yoilsho	2711	28	.	.	.
cord-006229-7yoilsho	2712	1	The	the	DT
cord-006229-7yoilsho	2712	2	muscle	muscle	NN
cord-006229-7yoilsho	2712	3	force	force	NN
cord-006229-7yoilsho	2712	4	dropped	drop	VBD
cord-006229-7yoilsho	2712	5	during	during	IN
cord-006229-7yoilsho	2712	6	the	the	DT
cord-006229-7yoilsho	2712	7	experiment	experiment	NN
cord-006229-7yoilsho	2712	8	.	.	.
cord-006229-7yoilsho	2713	1	The	the	DT
cord-006229-7yoilsho	2713	2	application	application	NN
cord-006229-7yoilsho	2713	3	of	of	IN
cord-006229-7yoilsho	2713	4	the	the	DT
cord-006229-7yoilsho	2713	5	bispyridinium	bispyridinium	NN
cord-006229-7yoilsho	2713	6	compounds	compound	NNS
cord-006229-7yoilsho	2713	7	MB327	mb327	NN
cord-006229-7yoilsho	2713	8	(	(	-LRB-
cord-006229-7yoilsho	2713	9	1,1′-(propan-1,3-diyl	1,1′-(propan-1,3-diyl	CD
cord-006229-7yoilsho	2713	10	)	)	-RRB-
cord-006229-7yoilsho	2713	11	bis	bis	NNP
cord-006229-7yoilsho	2713	12	(	(	-LRB-
cord-006229-7yoilsho	2713	13	4-tertbutylpyridinium	4-tertbutylpyridinium	CD
cord-006229-7yoilsho	2713	14	)	)	-RRB-
cord-006229-7yoilsho	2713	15	di(iodide	di(iodide	NN
cord-006229-7yoilsho	2713	16	)	)	-RRB-
cord-006229-7yoilsho	2713	17	)	)	-RRB-
cord-006229-7yoilsho	2713	18	and	and	CC
cord-006229-7yoilsho	2713	19	MB420	MB420	NNP
cord-006229-7yoilsho	2713	20	(	(	-LRB-
cord-006229-7yoilsho	2713	21	1,1′-(propan-1,3-diyl	1,1′-(propan-1,3-diyl	CD
cord-006229-7yoilsho	2713	22	)	)	-RRB-
cord-006229-7yoilsho	2713	23	bis	bis	NNP
cord-006229-7yoilsho	2713	24	(	(	-LRB-
cord-006229-7yoilsho	2713	25	2-ethylpyridinium	2-ethylpyridinium	CD
cord-006229-7yoilsho	2713	26	)	)	-RRB-
cord-006229-7yoilsho	2713	27	di(iodide	di(iodide	NN
cord-006229-7yoilsho	2713	28	)	)	-RRB-
cord-006229-7yoilsho	2713	29	)	)	-RRB-
cord-006229-7yoilsho	2713	30	in	in	IN
cord-006229-7yoilsho	2713	31	the	the	DT
cord-006229-7yoilsho	2713	32	tested	test	VBN
cord-006229-7yoilsho	2713	33	concentration	concentration	NN
cord-006229-7yoilsho	2713	34	range	range	NN
cord-006229-7yoilsho	2713	35	(	(	-LRB-
cord-006229-7yoilsho	2713	36	1	1	CD
cord-006229-7yoilsho	2713	37	-	-	SYM
cord-006229-7yoilsho	2713	38	300	300	CD
cord-006229-7yoilsho	2713	39	µM	µm	NN
cord-006229-7yoilsho	2713	40	)	)	-RRB-
cord-006229-7yoilsho	2713	41	did	do	VBD
cord-006229-7yoilsho	2713	42	not	not	RB
cord-006229-7yoilsho	2713	43	change	change	VB
cord-006229-7yoilsho	2713	44	muscle	muscle	NN
cord-006229-7yoilsho	2713	45	force	force	NN
cord-006229-7yoilsho	2713	46	production	production	NN
cord-006229-7yoilsho	2713	47	compared	compare	VBN
cord-006229-7yoilsho	2713	48	to	to	IN
cord-006229-7yoilsho	2713	49	the	the	DT
cord-006229-7yoilsho	2713	50	sham	sham	NN
cord-006229-7yoilsho	2713	51	treated	treat	VBN
cord-006229-7yoilsho	2713	52	muscle	muscle	NN
cord-006229-7yoilsho	2713	53	.	.	.
cord-006229-7yoilsho	2714	1	This	this	DT
cord-006229-7yoilsho	2714	2	was	be	VBD
cord-006229-7yoilsho	2714	3	equally	equally	RB
cord-006229-7yoilsho	2714	4	true	true	JJ
cord-006229-7yoilsho	2714	5	for	for	IN
cord-006229-7yoilsho	2714	6	low	low	JJ
cord-006229-7yoilsho	2714	7	(	(	-LRB-
cord-006229-7yoilsho	2714	8	20	20	CD
cord-006229-7yoilsho	2714	9	Hz	Hz	NNP
cord-006229-7yoilsho	2714	10	)	)	-RRB-
cord-006229-7yoilsho	2714	11	and	and	CC
cord-006229-7yoilsho	2714	12	high	high	JJ
cord-006229-7yoilsho	2714	13	(	(	-LRB-
cord-006229-7yoilsho	2714	14	50	50	CD
cord-006229-7yoilsho	2714	15	and	and	CC
cord-006229-7yoilsho	2714	16	100	100	CD
cord-006229-7yoilsho	2714	17	Hz	Hz	NNS
cord-006229-7yoilsho	2714	18	)	)	-RRB-
cord-006229-7yoilsho	2714	19	stimulation	stimulation	NN
cord-006229-7yoilsho	2714	20	frequencies	frequency	NNS
cord-006229-7yoilsho	2714	21	.	.	.
cord-006229-7yoilsho	2715	1	This	this	DT
cord-006229-7yoilsho	2715	2	study	study	NN
cord-006229-7yoilsho	2715	3	showed	show	VBD
cord-006229-7yoilsho	2715	4	that	that	IN
cord-006229-7yoilsho	2715	5	bispyridinium	bispyridinium	NN
cord-006229-7yoilsho	2715	6	compounds	compound	NNS
cord-006229-7yoilsho	2715	7	which	which	WDT
cord-006229-7yoilsho	2715	8	can	can	MD
cord-006229-7yoilsho	2715	9	partially	partially	RB
cord-006229-7yoilsho	2715	10	reverse	reverse	VB
cord-006229-7yoilsho	2715	11	somaninduced	somaninduce	VBN
cord-006229-7yoilsho	2715	12	neuromuscular	neuromuscular	JJ
cord-006229-7yoilsho	2715	13	block	block	NN
cord-006229-7yoilsho	2715	14	in	in	IN
cord-006229-7yoilsho	2715	15	rat	rat	NN
cord-006229-7yoilsho	2715	16	diaphragms	diaphragm	NNS
cord-006229-7yoilsho	2715	17	show	show	VBP
cord-006229-7yoilsho	2715	18	no	no	DT
cord-006229-7yoilsho	2715	19	effect	effect	NN
cord-006229-7yoilsho	2715	20	on	on	IN
cord-006229-7yoilsho	2715	21	respiratory	respiratory	JJ
cord-006229-7yoilsho	2715	22	muscle	muscle	NN
cord-006229-7yoilsho	2715	23	function	function	NN
cord-006229-7yoilsho	2715	24	in	in	IN
cord-006229-7yoilsho	2715	25	absence	absence	NN
cord-006229-7yoilsho	2715	26	of	of	IN
cord-006229-7yoilsho	2715	27	the	the	DT
cord-006229-7yoilsho	2715	28	OP	OP	NNP
cord-006229-7yoilsho	2715	29	-	-	HYPH
cord-006229-7yoilsho	2715	30	induced	induce	VBN
cord-006229-7yoilsho	2715	31	neuromuscular	neuromuscular	JJ
cord-006229-7yoilsho	2715	32	block	block	NN
cord-006229-7yoilsho	2715	33	.	.	.
cord-006229-7yoilsho	2716	1	These	these	DT
cord-006229-7yoilsho	2716	2	results	result	NNS
cord-006229-7yoilsho	2716	3	suggest	suggest	VBP
cord-006229-7yoilsho	2716	4	that	that	IN
cord-006229-7yoilsho	2716	5	the	the	DT
cord-006229-7yoilsho	2716	6	BP	BP	NNP
cord-006229-7yoilsho	2716	7	tested	test	VBD
cord-006229-7yoilsho	2716	8	in	in	IN
cord-006229-7yoilsho	2716	9	this	this	DT
cord-006229-7yoilsho	2716	10	study	study	NN
cord-006229-7yoilsho	2716	11	interacted	interact	VBD
cord-006229-7yoilsho	2716	12	with	with	IN
cord-006229-7yoilsho	2716	13	desensitised	desensitised	NNP
cord-006229-7yoilsho	2716	14	nAChRs	nAChRs	NNP
cord-006229-7yoilsho	2716	15	only	only	RB
cord-006229-7yoilsho	2716	16	,	,	,
cord-006229-7yoilsho	2716	17	but	but	CC
cord-006229-7yoilsho	2716	18	do	do	VBP
cord-006229-7yoilsho	2716	19	not	not	RB
cord-006229-7yoilsho	2716	20	affect	affect	VB
cord-006229-7yoilsho	2716	21	physiological	physiological	JJ
cord-006229-7yoilsho	2716	22	neuromuscular	neuromuscular	JJ
cord-006229-7yoilsho	2716	23	transmission	transmission	NN
cord-006229-7yoilsho	2716	24	.	.	.
cord-006229-7yoilsho	2717	1	This	this	DT
cord-006229-7yoilsho	2717	2	effect	effect	NN
cord-006229-7yoilsho	2717	3	needs	need	VBZ
cord-006229-7yoilsho	2717	4	to	to	TO
cord-006229-7yoilsho	2717	5	be	be	VB
cord-006229-7yoilsho	2717	6	investigated	investigate	VBN
cord-006229-7yoilsho	2717	7	with	with	IN
cord-006229-7yoilsho	2717	8	further	further	RB
cord-006229-7yoilsho	2717	9	,	,	,
cord-006229-7yoilsho	2717	10	promising	promise	VBG
cord-006229-7yoilsho	2717	11	BP	BP	NNP
cord-006229-7yoilsho	2717	12	compounds	compound	NNS
cord-006229-7yoilsho	2717	13	.	.	.
cord-006229-7yoilsho	2718	1	Interaction	interaction	NN
cord-006229-7yoilsho	2718	2	of	of	IN
cord-006229-7yoilsho	2718	3	recombinant	recombinant	JJ
cord-006229-7yoilsho	2718	4	pain	pain	NN
cord-006229-7yoilsho	2718	5	-	-	HYPH
cord-006229-7yoilsho	2718	6	relevant	relevant	JJ
cord-006229-7yoilsho	2718	7	ATP	ATP	NNP
cord-006229-7yoilsho	2718	8	-	-	HYPH
cord-006229-7yoilsho	2718	9	and	and	CC
cord-006229-7yoilsho	2718	10	proton	proton	NN
cord-006229-7yoilsho	2718	11	-	-	HYPH
cord-006229-7yoilsho	2718	12	gated	gate	VBN
cord-006229-7yoilsho	2718	13	ion	ion	NN
cord-006229-7yoilsho	2718	14	channels	channel	NNS
cord-006229-7yoilsho	2718	15	in	in	IN
cord-006229-7yoilsho	2718	16	an	an	DT
cord-006229-7yoilsho	2718	17	expression	expression	NN
cord-006229-7yoilsho	2718	18	system	system	NN
cord-006229-7yoilsho	2718	19	;	;	:
cord-006229-7yoilsho	2718	20	potentiation	potentiation	NN
cord-006229-7yoilsho	2718	21	of	of	IN
cord-006229-7yoilsho	2718	22	the	the	DT
cord-006229-7yoilsho	2718	23	P2X3	P2X3	NNP
cord-006229-7yoilsho	2718	24	receptor	receptor	NN
cord-006229-7yoilsho	2718	25	-	-	HYPH
cord-006229-7yoilsho	2718	26	induced	induce	VBN
cord-006229-7yoilsho	2718	27	current	current	NN
cord-006229-7yoilsho	2718	28	by	by	IN
cord-006229-7yoilsho	2718	29	the	the	DT
cord-006229-7yoilsho	2718	30	opening	opening	NN
cord-006229-7yoilsho	2718	31	of	of	IN
cord-006229-7yoilsho	2718	32	ASIC3	asic3	DT
cord-006229-7yoilsho	2718	33	channels	channel	NNS
cord-006229-7yoilsho	2718	34	G.	G.	NNP
cord-006229-7yoilsho	2718	35	Stephan	Stephan	NNP
cord-006229-7yoilsho	2718	36	1	1	CD
cord-006229-7yoilsho	2718	37	,	,	,
cord-006229-7yoilsho	2718	38	P.	P.	NNP
cord-006229-7yoilsho	2718	39	Illes	Illes	NNP
cord-006229-7yoilsho	2718	40	1	1	CD
cord-006229-7yoilsho	2718	41	1	1	CD
cord-006229-7yoilsho	2718	42	Universität	Universität	NNP
cord-006229-7yoilsho	2718	43	Leipzig	Leipzig	NNP
cord-006229-7yoilsho	2718	44	,	,	,
cord-006229-7yoilsho	2718	45	Rudolf	Rudolf	NNP
cord-006229-7yoilsho	2718	46	-	-	HYPH
cord-006229-7yoilsho	2718	47	Boehm	Boehm	NNP
cord-006229-7yoilsho	2718	48	-	-	HYPH
cord-006229-7yoilsho	2718	49	Institut	Institut	NNP
cord-006229-7yoilsho	2718	50	für	für	NNP
cord-006229-7yoilsho	2718	51	Pharmakologie	Pharmakologie	NNP
cord-006229-7yoilsho	2718	52	und	und	IN
cord-006229-7yoilsho	2718	53	Toxikologie	Toxikologie	NNP
cord-006229-7yoilsho	2718	54	,	,	,
cord-006229-7yoilsho	2718	55	Leipzig	Leipzig	NNP
cord-006229-7yoilsho	2718	56	,	,	,
cord-006229-7yoilsho	2718	57	Germany	Germany	NNP
cord-006229-7yoilsho	2719	1	The	the	DT
cord-006229-7yoilsho	2719	2	P2X3	P2X3	NNP
cord-006229-7yoilsho	2719	3	receptor	receptor	NN
cord-006229-7yoilsho	2719	4	(	(	-LRB-
cord-006229-7yoilsho	2719	5	R	r	NN
cord-006229-7yoilsho	2719	6	)	)	-RRB-
cord-006229-7yoilsho	2719	7	is	be	VBZ
cord-006229-7yoilsho	2719	8	a	a	DT
cord-006229-7yoilsho	2719	9	ligand	ligand	NN
cord-006229-7yoilsho	2719	10	-	-	HYPH
cord-006229-7yoilsho	2719	11	gated	gate	VBN
cord-006229-7yoilsho	2719	12	cationic	cationic	JJ
cord-006229-7yoilsho	2719	13	channel	channel	NN
cord-006229-7yoilsho	2719	14	,	,	,
cord-006229-7yoilsho	2719	15	which	which	WDT
cord-006229-7yoilsho	2719	16	is	be	VBZ
cord-006229-7yoilsho	2719	17	activated	activate	VBN
cord-006229-7yoilsho	2719	18	by	by	IN
cord-006229-7yoilsho	2719	19	extracellular	extracellular	JJ
cord-006229-7yoilsho	2719	20	ATP	ATP	NNP
cord-006229-7yoilsho	2719	21	.	.	.
cord-006229-7yoilsho	2720	1	The	the	DT
cord-006229-7yoilsho	2720	2	acid	acid	NN
cord-006229-7yoilsho	2720	3	sensing	sensing	NN
cord-006229-7yoilsho	2720	4	ion	ion	NN
cord-006229-7yoilsho	2720	5	channel	channel	NN
cord-006229-7yoilsho	2720	6	3	3	CD
cord-006229-7yoilsho	2721	1	(	(	-LRB-
cord-006229-7yoilsho	2721	2	ASIC3	ASIC3	NNP
cord-006229-7yoilsho	2721	3	)	)	-RRB-
cord-006229-7yoilsho	2721	4	belongs	belong	VBZ
cord-006229-7yoilsho	2721	5	to	to	IN
cord-006229-7yoilsho	2721	6	the	the	DT
cord-006229-7yoilsho	2721	7	ENaC	ENaC	NNP
cord-006229-7yoilsho	2721	8	/	/	SYM
cord-006229-7yoilsho	2721	9	degenerin	degenerin	NN
cord-006229-7yoilsho	2721	10	family	family	NN
cord-006229-7yoilsho	2721	11	and	and	CC
cord-006229-7yoilsho	2721	12	is	be	VBZ
cord-006229-7yoilsho	2721	13	gated	gate	VBN
cord-006229-7yoilsho	2721	14	by	by	IN
cord-006229-7yoilsho	2721	15	extracellular	extracellular	JJ
cord-006229-7yoilsho	2721	16	protons	proton	NNS
cord-006229-7yoilsho	2721	17	.	.	.
cord-006229-7yoilsho	2722	1	Despite	despite	IN
cord-006229-7yoilsho	2722	2	their	-PRON-	PRP$
cord-006229-7yoilsho	2722	3	different	different	JJ
cord-006229-7yoilsho	2722	4	amino	amino	NN
cord-006229-7yoilsho	2722	5	acid	acid	NN
cord-006229-7yoilsho	2722	6	sequences	sequence	NNS
cord-006229-7yoilsho	2722	7	both	both	CC
cord-006229-7yoilsho	2722	8	ion	ion	NN
cord-006229-7yoilsho	2722	9	channels	channel	NNS
cord-006229-7yoilsho	2722	10	share	share	VBP
cord-006229-7yoilsho	2722	11	the	the	DT
cord-006229-7yoilsho	2722	12	same	same	JJ
cord-006229-7yoilsho	2722	13	structure	structure	NN
cord-006229-7yoilsho	2722	14	and	and	CC
cord-006229-7yoilsho	2722	15	pore	pore	NN
cord-006229-7yoilsho	2722	16	architecture	architecture	NN
cord-006229-7yoilsho	2722	17	,	,	,
cord-006229-7yoilsho	2722	18	by	by	IN
cord-006229-7yoilsho	2722	19	i.e.	i.e.	FW
cord-006229-7yoilsho	2722	20	consisting	consist	VBG
cord-006229-7yoilsho	2722	21	of	of	IN
cord-006229-7yoilsho	2722	22	three	three	CD
cord-006229-7yoilsho	2722	23	identical	identical	JJ
cord-006229-7yoilsho	2722	24	subunits	subunit	NNS
cord-006229-7yoilsho	2722	25	.	.	.
cord-006229-7yoilsho	2723	1	Besides	besides	RB
cord-006229-7yoilsho	2723	2	,	,	,
cord-006229-7yoilsho	2723	3	they	-PRON-	PRP
cord-006229-7yoilsho	2723	4	are	be	VBP
cord-006229-7yoilsho	2723	5	both	both	DT
cord-006229-7yoilsho	2723	6	located	locate	VBN
cord-006229-7yoilsho	2723	7	at	at	IN
cord-006229-7yoilsho	2723	8	partially	partially	RB
cord-006229-7yoilsho	2723	9	overlapping	overlap	VBG
cord-006229-7yoilsho	2723	10	subpopulations	subpopulation	NNS
cord-006229-7yoilsho	2723	11	of	of	IN
cord-006229-7yoilsho	2723	12	dorsal	dorsal	JJ
cord-006229-7yoilsho	2723	13	root	root	NN
cord-006229-7yoilsho	2723	14	ganglia	ganglion	NNS
cord-006229-7yoilsho	2723	15	neurons	neuron	NNS
cord-006229-7yoilsho	2723	16	and	and	CC
cord-006229-7yoilsho	2723	17	are	be	VBP
cord-006229-7yoilsho	2723	18	implicated	implicate	VBN
cord-006229-7yoilsho	2723	19	in	in	IN
cord-006229-7yoilsho	2723	20	acidic	acidic	JJ
cord-006229-7yoilsho	2723	21	pain	pain	NN
cord-006229-7yoilsho	2723	22	signaling	signaling	NN
cord-006229-7yoilsho	2723	23	.	.	.
cord-006229-7yoilsho	2724	1	Consequently	consequently	RB
cord-006229-7yoilsho	2724	2	,	,	,
cord-006229-7yoilsho	2724	3	their	-PRON-	PRP$
cord-006229-7yoilsho	2724	4	physical	physical	JJ
cord-006229-7yoilsho	2724	5	interaction	interaction	NN
cord-006229-7yoilsho	2724	6	in	in	IN
cord-006229-7yoilsho	2724	7	the	the	DT
cord-006229-7yoilsho	2724	8	cell	cell	NN
cord-006229-7yoilsho	2724	9	membrane	membrane	NN
cord-006229-7yoilsho	2724	10	or	or	CC
cord-006229-7yoilsho	2724	11	even	even	RB
cord-006229-7yoilsho	2724	12	the	the	DT
cord-006229-7yoilsho	2724	13	formation	formation	NN
cord-006229-7yoilsho	2724	14	of	of	IN
cord-006229-7yoilsho	2724	15	heteromeric	heteromeric	JJ
cord-006229-7yoilsho	2724	16	receptor	receptor	NN
cord-006229-7yoilsho	2724	17	channels	channel	NNS
cord-006229-7yoilsho	2724	18	from	from	IN
cord-006229-7yoilsho	2724	19	P2X3	P2X3	NNP
cord-006229-7yoilsho	2724	20	and	and	CC
cord-006229-7yoilsho	2724	21	ASIC3	asic3	DT
cord-006229-7yoilsho	2724	22	subunits	subunit	NNS
cord-006229-7yoilsho	2724	23	has	have	VBZ
cord-006229-7yoilsho	2724	24	to	to	TO
cord-006229-7yoilsho	2724	25	be	be	VB
cord-006229-7yoilsho	2724	26	taken	take	VBN
cord-006229-7yoilsho	2724	27	into	into	IN
cord-006229-7yoilsho	2724	28	consideration	consideration	NN
cord-006229-7yoilsho	2724	29	.	.	.
cord-006229-7yoilsho	2725	1	We	-PRON-	PRP
cord-006229-7yoilsho	2725	2	transfected	transfecte	VBD
cord-006229-7yoilsho	2725	3	rat	rat	NN
cord-006229-7yoilsho	2725	4	(	(	-LRB-
cord-006229-7yoilsho	2725	5	r)P2X3R	r)P2X3R	NNP
cord-006229-7yoilsho	2725	6	and	and	CC
cord-006229-7yoilsho	2725	7	rASIC3	rASIC3	NNP
cord-006229-7yoilsho	2725	8	constructs	construct	VBZ
cord-006229-7yoilsho	2725	9	individually	individually	RB
cord-006229-7yoilsho	2725	10	or	or	CC
cord-006229-7yoilsho	2725	11	together	together	RB
cord-006229-7yoilsho	2725	12	in	in	IN
cord-006229-7yoilsho	2725	13	a	a	DT
cord-006229-7yoilsho	2725	14	ratio	ratio	NN
cord-006229-7yoilsho	2725	15	of	of	IN
cord-006229-7yoilsho	2725	16	1:1	1:1	CD
cord-006229-7yoilsho	2725	17	into	into	IN
cord-006229-7yoilsho	2725	18	CHO	CHO	NNP
cord-006229-7yoilsho	2725	19	cells	cell	NNS
cord-006229-7yoilsho	2725	20	.	.	.
cord-006229-7yoilsho	2726	1	We	-PRON-	PRP
cord-006229-7yoilsho	2726	2	further	further	RB
cord-006229-7yoilsho	2726	3	used	use	VBD
cord-006229-7yoilsho	2726	4	the	the	DT
cord-006229-7yoilsho	2726	5	whole	whole	JJ
cord-006229-7yoilsho	2726	6	cell	cell	NN
cord-006229-7yoilsho	2726	7	patch	patch	NN
cord-006229-7yoilsho	2726	8	clamp	clamp	NN
cord-006229-7yoilsho	2726	9	technique	technique	NN
cord-006229-7yoilsho	2726	10	to	to	TO
cord-006229-7yoilsho	2726	11	analyze	analyze	VB
cord-006229-7yoilsho	2726	12	the	the	DT
cord-006229-7yoilsho	2726	13	current	current	JJ
cord-006229-7yoilsho	2726	14	responses	response	NNS
cord-006229-7yoilsho	2726	15	either	either	CC
cord-006229-7yoilsho	2726	16	elicited	elicit	VBN
cord-006229-7yoilsho	2726	17	by	by	IN
cord-006229-7yoilsho	2726	18	the	the	DT
cord-006229-7yoilsho	2726	19	application	application	NN
cord-006229-7yoilsho	2726	20	of	of	IN
cord-006229-7yoilsho	2726	21	α	α	NNP
cord-006229-7yoilsho	2726	22	,	,	,
cord-006229-7yoilsho	2726	23	β	β	NN
cord-006229-7yoilsho	2726	24	-	-	HYPH
cord-006229-7yoilsho	2726	25	methylene	methylene	NNP
cord-006229-7yoilsho	2726	26	-	-	HYPH
cord-006229-7yoilsho	2726	27	ATP	ATP	NNP
cord-006229-7yoilsho	2726	28	(	(	-LRB-
cord-006229-7yoilsho	2726	29	α	α	NNP
cord-006229-7yoilsho	2726	30	,	,	,
cord-006229-7yoilsho	2726	31	β	β	NN
cord-006229-7yoilsho	2726	32	-	-	HYPH
cord-006229-7yoilsho	2726	33	meATP	meATP	NNP
cord-006229-7yoilsho	2726	34	)	)	-RRB-
cord-006229-7yoilsho	2726	35	or	or	CC
cord-006229-7yoilsho	2726	36	by	by	IN
cord-006229-7yoilsho	2726	37	a	a	DT
cord-006229-7yoilsho	2726	38	decrease	decrease	NN
cord-006229-7yoilsho	2726	39	in	in	IN
cord-006229-7yoilsho	2726	40	the	the	DT
cord-006229-7yoilsho	2726	41	extracellular	extracellular	JJ
cord-006229-7yoilsho	2726	42	pH	pH	NNP
cord-006229-7yoilsho	2726	43	value	value	NN
cord-006229-7yoilsho	2726	44	.	.	.
cord-006229-7yoilsho	2727	1	The	the	DT
cord-006229-7yoilsho	2727	2	functionality	functionality	NN
cord-006229-7yoilsho	2727	3	of	of	IN
cord-006229-7yoilsho	2727	4	the	the	DT
cord-006229-7yoilsho	2727	5	individually	individually	RB
cord-006229-7yoilsho	2727	6	transfected	transfecte	VBN
cord-006229-7yoilsho	2727	7	P2X3R	P2X3R	NNP
cord-006229-7yoilsho	2727	8	-	-	:
cord-006229-7yoilsho	2727	9	and	and	CC
cord-006229-7yoilsho	2727	10	ASIC3-constructs	ASIC3-constructs	NNPS
cord-006229-7yoilsho	2727	11	was	be	VBD
cord-006229-7yoilsho	2727	12	verified	verify	VBN
cord-006229-7yoilsho	2727	13	by	by	IN
cord-006229-7yoilsho	2727	14	recording	record	VBG
cord-006229-7yoilsho	2727	15	concentration	concentration	NN
cord-006229-7yoilsho	2727	16	-	-	HYPH
cord-006229-7yoilsho	2727	17	response	response	NN
cord-006229-7yoilsho	2727	18	curves	curve	NNS
cord-006229-7yoilsho	2727	19	for	for	IN
cord-006229-7yoilsho	2727	20	the	the	DT
cord-006229-7yoilsho	2727	21	agonists	agonist	NNS
cord-006229-7yoilsho	2727	22	α	α	XX
cord-006229-7yoilsho	2727	23	,	,	,
cord-006229-7yoilsho	2727	24	β	β	NN
cord-006229-7yoilsho	2727	25	-	-	HYPH
cord-006229-7yoilsho	2727	26	meATP	meATP	NNP
cord-006229-7yoilsho	2727	27	and	and	CC
cord-006229-7yoilsho	2727	28	protons	proton	NNS
cord-006229-7yoilsho	2727	29	,	,	,
cord-006229-7yoilsho	2727	30	respectively	respectively	RB
cord-006229-7yoilsho	2727	31	.	.	.
cord-006229-7yoilsho	2728	1	After	after	IN
cord-006229-7yoilsho	2728	2	co	co	NN
cord-006229-7yoilsho	2728	3	-	-	NN
cord-006229-7yoilsho	2728	4	transfection	transfection	NN
cord-006229-7yoilsho	2728	5	of	of	IN
cord-006229-7yoilsho	2728	6	both	both	DT
cord-006229-7yoilsho	2728	7	ion	ion	NN
cord-006229-7yoilsho	2728	8	channels	channel	NNS
cord-006229-7yoilsho	2728	9	,	,	,
cord-006229-7yoilsho	2728	10	a	a	DT
cord-006229-7yoilsho	2728	11	pH	ph	NN
cord-006229-7yoilsho	2728	12	-	-	NN
cord-006229-7yoilsho	2728	13	shift	shift	NN
cord-006229-7yoilsho	2728	14	from	from	IN
cord-006229-7yoilsho	2728	15	7.4	7.4	CD
cord-006229-7yoilsho	2728	16	to	to	TO
cord-006229-7yoilsho	2728	17	6.7	6.7	CD
cord-006229-7yoilsho	2728	18	caused	cause	VBD
cord-006229-7yoilsho	2728	19	a	a	DT
cord-006229-7yoilsho	2728	20	rapidly	rapidly	RB
cord-006229-7yoilsho	2728	21	desensitizing	desensitize	VBG
cord-006229-7yoilsho	2728	22	current	current	JJ
cord-006229-7yoilsho	2728	23	response	response	NN
cord-006229-7yoilsho	2728	24	and	and	CC
cord-006229-7yoilsho	2728	25	a	a	DT
cord-006229-7yoilsho	2728	26	subsequent	subsequent	JJ
cord-006229-7yoilsho	2728	27	strong	strong	JJ
cord-006229-7yoilsho	2728	28	potentiation	potentiation	NN
cord-006229-7yoilsho	2728	29	of	of	IN
cord-006229-7yoilsho	2728	30	the	the	DT
cord-006229-7yoilsho	2728	31	α	α	NN
cord-006229-7yoilsho	2728	32	,	,	,
cord-006229-7yoilsho	2728	33	β	β	NN
cord-006229-7yoilsho	2728	34	-	-	HYPH
cord-006229-7yoilsho	2728	35	meATP	meATP	VBG
cord-006229-7yoilsho	2728	36	-	-	HYPH
cord-006229-7yoilsho	2728	37	induced	induce	VBN
cord-006229-7yoilsho	2728	38	current	current	NN
cord-006229-7yoilsho	2728	39	.	.	.
cord-006229-7yoilsho	2729	1	An	an	DT
cord-006229-7yoilsho	2729	2	even	even	RB
cord-006229-7yoilsho	2729	3	larger	large	JJR
cord-006229-7yoilsho	2729	4	potentiation	potentiation	NN
cord-006229-7yoilsho	2729	5	was	be	VBD
cord-006229-7yoilsho	2729	6	achieved	achieve	VBN
cord-006229-7yoilsho	2729	7	after	after	IN
cord-006229-7yoilsho	2729	8	a	a	DT
cord-006229-7yoilsho	2729	9	decrease	decrease	NN
cord-006229-7yoilsho	2729	10	of	of	IN
cord-006229-7yoilsho	2729	11	the	the	DT
cord-006229-7yoilsho	2729	12	pH	pH	NNP
cord-006229-7yoilsho	2729	13	value	value	NN
cord-006229-7yoilsho	2729	14	to	to	IN
cord-006229-7yoilsho	2729	15	6.5	6.5	CD
cord-006229-7yoilsho	2729	16	.	.	.
cord-006229-7yoilsho	2730	1	The	the	DT
cord-006229-7yoilsho	2730	2	opening	opening	NN
cord-006229-7yoilsho	2730	3	of	of	IN
cord-006229-7yoilsho	2730	4	ASIC3	asic3	DT
cord-006229-7yoilsho	2730	5	channels	channel	NNS
cord-006229-7yoilsho	2730	6	failed	fail	VBD
cord-006229-7yoilsho	2730	7	to	to	TO
cord-006229-7yoilsho	2730	8	facilitate	facilitate	VB
cord-006229-7yoilsho	2730	9	the	the	DT
cord-006229-7yoilsho	2730	10	P2X3R	P2X3R	NNP
cord-006229-7yoilsho	2730	11	current	current	NN
cord-006229-7yoilsho	2730	12	when	when	WRB
cord-006229-7yoilsho	2730	13	2-guanidine-4-methylquinazoline	2-guanidine-4-methylquinazoline	CD
cord-006229-7yoilsho	2730	14	was	be	VBD
cord-006229-7yoilsho	2730	15	used	use	VBN
cord-006229-7yoilsho	2730	16	to	to	TO
cord-006229-7yoilsho	2730	17	stimulate	stimulate	VB
cord-006229-7yoilsho	2730	18	a	a	DT
cord-006229-7yoilsho	2730	19	non	non	JJ
cord-006229-7yoilsho	2730	20	-	-	JJ
cord-006229-7yoilsho	2730	21	proton	proton	JJ
cord-006229-7yoilsho	2730	22	ligand	ligand	NN
cord-006229-7yoilsho	2730	23	-	-	HYPH
cord-006229-7yoilsho	2730	24	sensor	sensor	NN
cord-006229-7yoilsho	2730	25	of	of	IN
cord-006229-7yoilsho	2730	26	ASIC3	ASIC3	NNS
cord-006229-7yoilsho	2730	27	.	.	.
cord-006229-7yoilsho	2731	1	Then	then	RB
cord-006229-7yoilsho	2731	2	,	,	,
cord-006229-7yoilsho	2731	3	we	-PRON-	PRP
cord-006229-7yoilsho	2731	4	substituted	substitute	VBD
cord-006229-7yoilsho	2732	1	Ca	Ca	NNP
cord-006229-7yoilsho	2732	2	2	2	CD
cord-006229-7yoilsho	2732	3	+	+	CC
cord-006229-7yoilsho	2732	4	in	in	IN
cord-006229-7yoilsho	2732	5	the	the	DT
cord-006229-7yoilsho	2732	6	extracellular	extracellular	JJ
cord-006229-7yoilsho	2732	7	medium	medium	NN
cord-006229-7yoilsho	2732	8	by	by	IN
cord-006229-7yoilsho	2732	9	Ba	Ba	NNP
cord-006229-7yoilsho	2732	10	2	2	CD
cord-006229-7yoilsho	2732	11	+	+	SYM
cord-006229-7yoilsho	2732	12	or	or	CC
cord-006229-7yoilsho	2732	13	decreased	decrease	VBD
cord-006229-7yoilsho	2732	14	the	the	DT
cord-006229-7yoilsho	2732	15	intrapipette	intrapipette	NN
cord-006229-7yoilsho	2732	16	concentration	concentration	NN
cord-006229-7yoilsho	2732	17	of	of	IN
cord-006229-7yoilsho	2732	18	EGTA	EGTA	NNP
cord-006229-7yoilsho	2732	19	,	,	,
cord-006229-7yoilsho	2733	1	to	to	TO
cord-006229-7yoilsho	2733	2	modify	modify	VB
cord-006229-7yoilsho	2733	3	the	the	DT
cord-006229-7yoilsho	2733	4	free	free	JJ
cord-006229-7yoilsho	2733	5	intracellular	intracellular	JJ
cord-006229-7yoilsho	2733	6	Ca	Ca	NNP
cord-006229-7yoilsho	2733	7	2	2	CD
cord-006229-7yoilsho	2733	8	+	+	CC
cord-006229-7yoilsho	2733	9	concentration	concentration	NN
cord-006229-7yoilsho	2733	10	.	.	.
cord-006229-7yoilsho	2734	1	In	in	IN
cord-006229-7yoilsho	2734	2	cells	cell	NNS
cord-006229-7yoilsho	2734	3	individually	individually	RB
cord-006229-7yoilsho	2734	4	transfected	transfecte	VBN
cord-006229-7yoilsho	2734	5	with	with	IN
cord-006229-7yoilsho	2734	6	the	the	DT
cord-006229-7yoilsho	2734	7	receptor	receptor	NN
cord-006229-7yoilsho	2734	8	-	-	HYPH
cord-006229-7yoilsho	2734	9	channels	channel	NNS
cord-006229-7yoilsho	2734	10	,	,	,
cord-006229-7yoilsho	2734	11	external	external	JJ
cord-006229-7yoilsho	2734	12	Ba	Ba	NNP
cord-006229-7yoilsho	2734	13	2	2	CD
cord-006229-7yoilsho	2734	14	+	+	SYM
cord-006229-7yoilsho	2734	15	increased	increase	VBD
cord-006229-7yoilsho	2734	16	the	the	DT
cord-006229-7yoilsho	2734	17	effect	effect	NN
cord-006229-7yoilsho	2734	18	of	of	IN
cord-006229-7yoilsho	2734	19	α	α	NN
cord-006229-7yoilsho	2734	20	,	,	,
cord-006229-7yoilsho	2734	21	β	β	NN
cord-006229-7yoilsho	2734	22	-	-	HYPH
cord-006229-7yoilsho	2734	23	meATP	meatp	NN
cord-006229-7yoilsho	2734	24	but	but	CC
cord-006229-7yoilsho	2734	25	decreased	decrease	VBD
cord-006229-7yoilsho	2734	26	the	the	DT
cord-006229-7yoilsho	2734	27	effect	effect	NN
cord-006229-7yoilsho	2734	28	of	of	IN
cord-006229-7yoilsho	2734	29	protons	proton	NNS
cord-006229-7yoilsho	2734	30	.	.	.
cord-006229-7yoilsho	2735	1	The	the	DT
cord-006229-7yoilsho	2735	2	lowering	lowering	NN
cord-006229-7yoilsho	2735	3	of	of	IN
cord-006229-7yoilsho	2735	4	intrapipette	intrapipette	NN
cord-006229-7yoilsho	2735	5	EGTA	EGTA	NNP
cord-006229-7yoilsho	2735	6	modified	modify	VBN
cord-006229-7yoilsho	2735	7	P2X3R	P2X3R	NNP
cord-006229-7yoilsho	2735	8	-	-	:
cord-006229-7yoilsho	2735	9	and	and	CC
cord-006229-7yoilsho	2735	10	ASIC3-specific	ASIC3-specific	NNP
cord-006229-7yoilsho	2735	11	currents	current	NNS
cord-006229-7yoilsho	2735	12	in	in	IN
cord-006229-7yoilsho	2735	13	a	a	DT
cord-006229-7yoilsho	2735	14	similar	similar	JJ
cord-006229-7yoilsho	2735	15	manner	manner	NN
cord-006229-7yoilsho	2735	16	as	as	IN
cord-006229-7yoilsho	2735	17	external	external	JJ
cord-006229-7yoilsho	2735	18	Ba	Ba	NNP
cord-006229-7yoilsho	2735	19	2	2	CD
cord-006229-7yoilsho	2735	20	+	+	SYM
cord-006229-7yoilsho	2735	21	.	.	.
cord-006229-7yoilsho	2736	1	In	in	IN
cord-006229-7yoilsho	2736	2	cells	cell	NNS
cord-006229-7yoilsho	2736	3	co	co	VBD
cord-006229-7yoilsho	2736	4	-	-	VBN
cord-006229-7yoilsho	2736	5	transfected	transfecte	VBN
cord-006229-7yoilsho	2737	1	with	with	IN
cord-006229-7yoilsho	2737	2	P2X3R	P2X3R	NNP
cord-006229-7yoilsho	2737	3	/	/	SYM
cord-006229-7yoilsho	2737	4	ASIC3	asic3	XX
cord-006229-7yoilsho	2737	5	,	,	,
cord-006229-7yoilsho	2738	1	the	the	DT
cord-006229-7yoilsho	2738	2	ionic	ionic	JJ
cord-006229-7yoilsho	2738	3	manipulations	manipulation	NNS
cord-006229-7yoilsho	2738	4	mentioned	mention	VBN
cord-006229-7yoilsho	2738	5	above	above	RB
cord-006229-7yoilsho	2738	6	abolished	abolish	VBD
cord-006229-7yoilsho	2738	7	the	the	DT
cord-006229-7yoilsho	2738	8	potentiation	potentiation	NN
cord-006229-7yoilsho	2738	9	of	of	IN
cord-006229-7yoilsho	2738	10	the	the	DT
cord-006229-7yoilsho	2738	11	α	α	NN
cord-006229-7yoilsho	2738	12	,	,	,
cord-006229-7yoilsho	2738	13	β	β	NN
cord-006229-7yoilsho	2738	14	-	-	HYPH
cord-006229-7yoilsho	2738	15	meATP	meATP	VBG
cord-006229-7yoilsho	2738	16	currents	current	NNS
cord-006229-7yoilsho	2738	17	by	by	IN
cord-006229-7yoilsho	2738	18	ASIC3	asic3	DT
cord-006229-7yoilsho	2738	19	activation	activation	NN
cord-006229-7yoilsho	2738	20	.	.	.
cord-006229-7yoilsho	2739	1	Taken	take	VBN
cord-006229-7yoilsho	2739	2	together	together	RB
cord-006229-7yoilsho	2739	3	,	,	,
cord-006229-7yoilsho	2739	4	our	-PRON-	PRP$
cord-006229-7yoilsho	2739	5	results	result	NNS
cord-006229-7yoilsho	2739	6	suggest	suggest	VBP
cord-006229-7yoilsho	2739	7	that	that	IN
cord-006229-7yoilsho	2739	8	P2X3R	P2X3R	NNS
cord-006229-7yoilsho	2739	9	and	and	CC
cord-006229-7yoilsho	2739	10	ASIC3	ASIC3	VBZ
cord-006229-7yoilsho	2739	11	interact	interact	VB
cord-006229-7yoilsho	2739	12	with	with	IN
cord-006229-7yoilsho	2739	13	each	each	DT
cord-006229-7yoilsho	2739	14	other	other	JJ
cord-006229-7yoilsho	2739	15	,	,	,
cord-006229-7yoilsho	2739	16	since	since	IN
cord-006229-7yoilsho	2739	17	the	the	DT
cord-006229-7yoilsho	2739	18	activation	activation	NN
cord-006229-7yoilsho	2739	19	of	of	IN
cord-006229-7yoilsho	2739	20	ASIC3	ASIC3	NNP
cord-006229-7yoilsho	2739	21	had	have	VBD
cord-006229-7yoilsho	2739	22	a	a	DT
cord-006229-7yoilsho	2739	23	marked	marked	JJ
cord-006229-7yoilsho	2739	24	impact	impact	NN
cord-006229-7yoilsho	2739	25	on	on	IN
cord-006229-7yoilsho	2739	26	the	the	DT
cord-006229-7yoilsho	2739	27	P2X3R	P2X3R	NNP
cord-006229-7yoilsho	2739	28	specific	specific	JJ
cord-006229-7yoilsho	2739	29	current	current	JJ
cord-006229-7yoilsho	2739	30	response	response	NN
cord-006229-7yoilsho	2739	31	.	.	.
cord-006229-7yoilsho	2740	1	Further	further	JJ
cord-006229-7yoilsho	2740	2	experiments	experiment	NNS
cord-006229-7yoilsho	2740	3	are	be	VBP
cord-006229-7yoilsho	2740	4	required	require	VBN
cord-006229-7yoilsho	2740	5	to	to	TO
cord-006229-7yoilsho	2740	6	clarify	clarify	VB
cord-006229-7yoilsho	2740	7	the	the	DT
cord-006229-7yoilsho	2740	8	mechanism	mechanism	NN
cord-006229-7yoilsho	2740	9	of	of	IN
cord-006229-7yoilsho	2740	10	this	this	DT
cord-006229-7yoilsho	2740	11	interaction	interaction	NN
cord-006229-7yoilsho	2740	12	,	,	,
cord-006229-7yoilsho	2740	13	although	although	IN
cord-006229-7yoilsho	2740	14	it	-PRON-	PRP
cord-006229-7yoilsho	2740	15	has	have	VBZ
cord-006229-7yoilsho	2740	16	been	be	VBN
cord-006229-7yoilsho	2740	17	shown	show	VBN
cord-006229-7yoilsho	2740	18	that	that	IN
cord-006229-7yoilsho	2740	19	extra	extra	JJ
cord-006229-7yoilsho	2740	20	-	-	:
cord-006229-7yoilsho	2740	21	and	and	CC
cord-006229-7yoilsho	2740	22	intracellular	intracellular	JJ
cord-006229-7yoilsho	2740	23	Ca	Ca	NNP
cord-006229-7yoilsho	2740	24	2	2	CD
cord-006229-7yoilsho	2740	25	+	+	SYM
cord-006229-7yoilsho	2740	26	and	and	CC
cord-006229-7yoilsho	2740	27	the	the	DT
cord-006229-7yoilsho	2740	28	proton	proton	NN
cord-006229-7yoilsho	2740	29	sensor	sensor	NN
cord-006229-7yoilsho	2740	30	of	of	IN
cord-006229-7yoilsho	2740	31	ASIC3	asic3	DT
cord-006229-7yoilsho	2740	32	appear	appear	VBP
cord-006229-7yoilsho	2740	33	to	to	TO
cord-006229-7yoilsho	2740	34	critically	critically	RB
cord-006229-7yoilsho	2740	35	participate	participate	VB
cord-006229-7yoilsho	2740	36	in	in	IN
cord-006229-7yoilsho	2740	37	this	this	DT
cord-006229-7yoilsho	2740	38	process	process	NN
cord-006229-7yoilsho	2740	39	.	.	.
cord-006229-7yoilsho	2741	1	University	University	NNP
cord-006229-7yoilsho	2741	2	of	of	IN
cord-006229-7yoilsho	2741	3	Duisburg	Duisburg	NNP
cord-006229-7yoilsho	2741	4	-	-	HYPH
cord-006229-7yoilsho	2741	5	Essen	Essen	NNP
cord-006229-7yoilsho	2741	6	,	,	,
cord-006229-7yoilsho	2741	7	Institute	Institute	NNP
cord-006229-7yoilsho	2741	8	for	for	IN
cord-006229-7yoilsho	2741	9	Anatomy	Anatomy	NNP
cord-006229-7yoilsho	2741	10	,	,	,
cord-006229-7yoilsho	2741	11	Essen	Essen	NNP
cord-006229-7yoilsho	2741	12	,	,	,
cord-006229-7yoilsho	2742	1	Germany	Germany	NNP
cord-006229-7yoilsho	2742	2	Background	Background	NNP
cord-006229-7yoilsho	2742	3	:	:	:
cord-006229-7yoilsho	2743	1	The	the	DT
cord-006229-7yoilsho	2743	2	sperm	sperm	NN
cord-006229-7yoilsho	2743	3	acrosome	acrosome	NN
cord-006229-7yoilsho	2743	4	reaction	reaction	NN
cord-006229-7yoilsho	2743	5	is	be	VBZ
cord-006229-7yoilsho	2743	6	an	an	DT
cord-006229-7yoilsho	2743	7	all	all	RB
cord-006229-7yoilsho	2743	8	-	-	HYPH
cord-006229-7yoilsho	2743	9	or	or	CC
cord-006229-7yoilsho	2743	10	-	-	HYPH
cord-006229-7yoilsho	2743	11	none	none	NN
cord-006229-7yoilsho	2743	12	secretion	secretion	NN
cord-006229-7yoilsho	2743	13	process	process	NN
cord-006229-7yoilsho	2743	14	,	,	,
cord-006229-7yoilsho	2743	15	mainly	mainly	RB
cord-006229-7yoilsho	2743	16	following	follow	VBG
cord-006229-7yoilsho	2743	17	the	the	DT
cord-006229-7yoilsho	2743	18	conserved	conserve	VBN
cord-006229-7yoilsho	2743	19	principles	principle	NNS
cord-006229-7yoilsho	2743	20	of	of	IN
cord-006229-7yoilsho	2743	21	calcium	calcium	NN
cord-006229-7yoilsho	2743	22	-	-	HYPH
cord-006229-7yoilsho	2743	23	regulated	regulate	VBN
cord-006229-7yoilsho	2743	24	exocytosis	exocytosis	NN
cord-006229-7yoilsho	2743	25	in	in	IN
cord-006229-7yoilsho	2743	26	neurons	neuron	NNS
cord-006229-7yoilsho	2743	27	and	and	CC
cord-006229-7yoilsho	2743	28	neurosecretory	neurosecretory	NN
cord-006229-7yoilsho	2743	29	cells	cell	NNS
cord-006229-7yoilsho	2743	30	.	.	.
cord-006229-7yoilsho	2744	1	However	however	RB
cord-006229-7yoilsho	2744	2	,	,	,
cord-006229-7yoilsho	2744	3	the	the	DT
cord-006229-7yoilsho	2744	4	relationship	relationship	NN
cord-006229-7yoilsho	2744	5	between	between	IN
cord-006229-7yoilsho	2744	6	the	the	DT
cord-006229-7yoilsho	2744	7	formation	formation	NN
cord-006229-7yoilsho	2744	8	of	of	IN
cord-006229-7yoilsho	2744	9	hundreds	hundred	NNS
cord-006229-7yoilsho	2744	10	of	of	IN
cord-006229-7yoilsho	2744	11	fusion	fusion	NN
cord-006229-7yoilsho	2744	12	pores	pore	NNS
cord-006229-7yoilsho	2744	13	and	and	CC
cord-006229-7yoilsho	2744	14	the	the	DT
cord-006229-7yoilsho	2744	15	required	required	JJ
cord-006229-7yoilsho	2744	16	mobilization	mobilization	NN
cord-006229-7yoilsho	2744	17	of	of	IN
cord-006229-7yoilsho	2744	18	calcium	calcium	NN
cord-006229-7yoilsho	2744	19	from	from	IN
cord-006229-7yoilsho	2744	20	the	the	DT
cord-006229-7yoilsho	2744	21	lysosome	lysosome	NN
cord-006229-7yoilsho	2744	22	-	-	HYPH
cord-006229-7yoilsho	2744	23	related	relate	VBN
cord-006229-7yoilsho	2744	24	acrosomal	acrosomal	JJ
cord-006229-7yoilsho	2744	25	vesicle	vesicle	NN
cord-006229-7yoilsho	2744	26	has	have	VBZ
cord-006229-7yoilsho	2744	27	only	only	RB
cord-006229-7yoilsho	2744	28	been	be	VBN
cord-006229-7yoilsho	2744	29	partially	partially	RB
cord-006229-7yoilsho	2744	30	defined	define	VBN
cord-006229-7yoilsho	2744	31	.	.	.
cord-006229-7yoilsho	2745	1	Hence	hence	RB
cord-006229-7yoilsho	2745	2	,	,	,
cord-006229-7yoilsho	2745	3	the	the	DT
cord-006229-7yoilsho	2745	4	second	second	JJ
cord-006229-7yoilsho	2745	5	messenger	messenger	NN
cord-006229-7yoilsho	2745	6	,	,	,
cord-006229-7yoilsho	2745	7	nicotinic	nicotinic	JJ
cord-006229-7yoilsho	2745	8	acid	acid	NN
cord-006229-7yoilsho	2745	9	adenine	adenine	NN
cord-006229-7yoilsho	2745	10	dinucleotide	dinucleotide	NN
cord-006229-7yoilsho	2745	11	phosphate	phosphate	NN
cord-006229-7yoilsho	2745	12	(	(	-LRB-
cord-006229-7yoilsho	2745	13	NAADP	NAADP	NNP
cord-006229-7yoilsho	2745	14	)	)	-RRB-
cord-006229-7yoilsho	2745	15	,	,	,
cord-006229-7yoilsho	2745	16	known	know	VBN
cord-006229-7yoilsho	2745	17	to	to	TO
cord-006229-7yoilsho	2745	18	promote	promote	VB
cord-006229-7yoilsho	2745	19	efflux	efflux	NN
cord-006229-7yoilsho	2745	20	of	of	IN
cord-006229-7yoilsho	2745	21	calcium	calcium	NN
cord-006229-7yoilsho	2745	22	from	from	IN
cord-006229-7yoilsho	2745	23	lysosome	lysosome	NN
cord-006229-7yoilsho	2745	24	-	-	HYPH
cord-006229-7yoilsho	2745	25	like	like	JJ
cord-006229-7yoilsho	2745	26	acidic	acidic	JJ
cord-006229-7yoilsho	2745	27	compartments	compartment	NNS
cord-006229-7yoilsho	2745	28	,	,	,
cord-006229-7yoilsho	2745	29	was	be	VBD
cord-006229-7yoilsho	2745	30	analyzed	analyze	VBN
cord-006229-7yoilsho	2745	31	for	for	IN
cord-006229-7yoilsho	2745	32	its	-PRON-	PRP$
cord-006229-7yoilsho	2745	33	ability	ability	NN
cord-006229-7yoilsho	2745	34	to	to	TO
cord-006229-7yoilsho	2745	35	trigger	trigger	VB
cord-006229-7yoilsho	2745	36	acrosome	acrosome	NNP
cord-006229-7yoilsho	2745	37	reaction	reaction	NN
cord-006229-7yoilsho	2745	38	in	in	IN
cord-006229-7yoilsho	2745	39	mouse	mouse	NN
cord-006229-7yoilsho	2745	40	sperm	sperm	NN
cord-006229-7yoilsho	2745	41	.	.	.
cord-006229-7yoilsho	2746	1	In	in	IN
cord-006229-7yoilsho	2746	2	addition	addition	NN
cord-006229-7yoilsho	2746	3	,	,	,
cord-006229-7yoilsho	2746	4	the	the	DT
cord-006229-7yoilsho	2746	5	expression	expression	NN
cord-006229-7yoilsho	2746	6	of	of	IN
cord-006229-7yoilsho	2746	7	two	two	CD
cord-006229-7yoilsho	2746	8	-	-	HYPH
cord-006229-7yoilsho	2746	9	pore	pore	NN
cord-006229-7yoilsho	2746	10	channel	channel	NN
cord-006229-7yoilsho	2746	11	(	(	-LRB-
cord-006229-7yoilsho	2746	12	TPC	TPC	NNP
cord-006229-7yoilsho	2746	13	)	)	-RRB-
cord-006229-7yoilsho	2746	14	proteins	protein	NNS
cord-006229-7yoilsho	2746	15	,	,	,
cord-006229-7yoilsho	2746	16	which	which	WDT
cord-006229-7yoilsho	2746	17	are	be	VBP
cord-006229-7yoilsho	2746	18	primarily	primarily	RB
cord-006229-7yoilsho	2746	19	localized	localize	VBN
cord-006229-7yoilsho	2746	20	in	in	IN
cord-006229-7yoilsho	2746	21	lysosome	lysosome	NN
cord-006229-7yoilsho	2746	22	-	-	HYPH
cord-006229-7yoilsho	2746	23	related	relate	VBN
cord-006229-7yoilsho	2746	24	acidic	acidic	JJ
cord-006229-7yoilsho	2746	25	organelles	organelle	NNS
cord-006229-7yoilsho	2746	26	and	and	CC
cord-006229-7yoilsho	2746	27	which	which	WDT
cord-006229-7yoilsho	2746	28	present	present	VBP
cord-006229-7yoilsho	2746	29	potential	potential	JJ
cord-006229-7yoilsho	2746	30	molecular	molecular	JJ
cord-006229-7yoilsho	2746	31	targets	target	NNS
cord-006229-7yoilsho	2746	32	of	of	IN
cord-006229-7yoilsho	2746	33	NAADP	NAADP	NNP
cord-006229-7yoilsho	2746	34	were	be	VBD
cord-006229-7yoilsho	2746	35	examined	examine	VBN
cord-006229-7yoilsho	2746	36	in	in	IN
cord-006229-7yoilsho	2746	37	mammalian	mammalian	JJ
cord-006229-7yoilsho	2746	38	spermatozoa	spermatozoon	NNS
cord-006229-7yoilsho	2746	39	.	.	.
cord-006229-7yoilsho	2747	1	Methodology/	Methodology/	NNP
cord-006229-7yoilsho	2747	2	Principal	Principal	NNP
cord-006229-7yoilsho	2747	3	Findings	Findings	NNPS
cord-006229-7yoilsho	2747	4	:	:	:
cord-006229-7yoilsho	2748	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	2748	2	results	result	NNS
cord-006229-7yoilsho	2748	3	show	show	VBP
cord-006229-7yoilsho	2748	4	that	that	IN
cord-006229-7yoilsho	2748	5	treatment	treatment	NN
cord-006229-7yoilsho	2748	6	of	of	IN
cord-006229-7yoilsho	2748	7	spermatozoa	spermatozoa	VBG
cord-006229-7yoilsho	2748	8	with	with	IN
cord-006229-7yoilsho	2748	9	NAADP	NAADP	NNP
cord-006229-7yoilsho	2748	10	resulted	result	VBD
cord-006229-7yoilsho	2748	11	in	in	IN
cord-006229-7yoilsho	2748	12	a	a	DT
cord-006229-7yoilsho	2748	13	loss	loss	NN
cord-006229-7yoilsho	2748	14	of	of	IN
cord-006229-7yoilsho	2748	15	the	the	DT
cord-006229-7yoilsho	2748	16	acrosomal	acrosomal	JJ
cord-006229-7yoilsho	2748	17	vesicle	vesicle	NN
cord-006229-7yoilsho	2748	18	,	,	,
cord-006229-7yoilsho	2748	19	which	which	WDT
cord-006229-7yoilsho	2748	20	shows	show	VBZ
cord-006229-7yoilsho	2748	21	typical	typical	JJ
cord-006229-7yoilsho	2748	22	properties	property	NNS
cord-006229-7yoilsho	2748	23	,	,	,
cord-006229-7yoilsho	2748	24	described	describe	VBN
cord-006229-7yoilsho	2748	25	for	for	IN
cord-006229-7yoilsho	2748	26	TPCs	tpc	NNS
cord-006229-7yoilsho	2748	27	:	:	:
cord-006229-7yoilsho	2748	28	(	(	-LRB-
cord-006229-7yoilsho	2748	29	i	i	NN
cord-006229-7yoilsho	2748	30	)	)	-RRB-
cord-006229-7yoilsho	2749	1	Registered	register	VBN
cord-006229-7yoilsho	2749	2	responses	response	NNS
cord-006229-7yoilsho	2749	3	were	be	VBD
cord-006229-7yoilsho	2749	4	not	not	RB
cord-006229-7yoilsho	2749	5	detectable	detectable	JJ
cord-006229-7yoilsho	2749	6	for	for	IN
cord-006229-7yoilsho	2749	7	its	-PRON-	PRP$
cord-006229-7yoilsho	2749	8	chemical	chemical	NN
cord-006229-7yoilsho	2749	9	analogue	analogue	NN
cord-006229-7yoilsho	2749	10	NADP	NADP	NNP
cord-006229-7yoilsho	2749	11	,	,	,
cord-006229-7yoilsho	2749	12	and	and	CC
cord-006229-7yoilsho	2749	13	(	(	-LRB-
cord-006229-7yoilsho	2749	14	ii	ii	NN
cord-006229-7yoilsho	2749	15	)	)	-RRB-
cord-006229-7yoilsho	2749	16	where	where	WRB
cord-006229-7yoilsho	2749	17	blocked	block	VBN
cord-006229-7yoilsho	2749	18	by	by	IN
cord-006229-7yoilsho	2749	19	the	the	DT
cord-006229-7yoilsho	2749	20	NAADP	NAADP	NNP
cord-006229-7yoilsho	2749	21	antagonist	antagonist	NN
cord-006229-7yoilsho	2749	22	trans	trans	NNP
cord-006229-7yoilsho	2749	23	-	-	NNP
cord-006229-7yoilsho	2749	24	Ned-19	Ned-19	NNP
cord-006229-7yoilsho	2749	25	.	.	.
cord-006229-7yoilsho	2750	1	In	in	IN
cord-006229-7yoilsho	2750	2	addition	addition	NN
cord-006229-7yoilsho	2750	3	,	,	,
cord-006229-7yoilsho	2750	4	(	(	-LRB-
cord-006229-7yoilsho	2750	5	iii	iii	NN
cord-006229-7yoilsho	2750	6	)	)	-RRB-
cord-006229-7yoilsho	2750	7	two	two	CD
cord-006229-7yoilsho	2750	8	narrow	narrow	JJ
cord-006229-7yoilsho	2750	9	bell	bell	NN
cord-006229-7yoilsho	2750	10	-	-	HYPH
cord-006229-7yoilsho	2750	11	shaped	shape	VBN
cord-006229-7yoilsho	2750	12	dose	dose	NN
cord-006229-7yoilsho	2750	13	-	-	HYPH
cord-006229-7yoilsho	2750	14	response	response	NN
cord-006229-7yoilsho	2750	15	-	-	HYPH
cord-006229-7yoilsho	2750	16	curves	curve	NNS
cord-006229-7yoilsho	2750	17	were	be	VBD
cord-006229-7yoilsho	2750	18	found	find	VBN
cord-006229-7yoilsho	2750	19	,	,	,
cord-006229-7yoilsho	2750	20	with	with	IN
cord-006229-7yoilsho	2750	21	maxima	maxima	NNP
cord-006229-7yoilsho	2750	22	either	either	CC
cord-006229-7yoilsho	2750	23	in	in	IN
cord-006229-7yoilsho	2750	24	the	the	DT
cord-006229-7yoilsho	2750	25	nanomolar	nanomolar	JJ
cord-006229-7yoilsho	2750	26	or	or	CC
cord-006229-7yoilsho	2750	27	low	low	JJ
cord-006229-7yoilsho	2750	28	micromolar	micromolar	JJ
cord-006229-7yoilsho	2750	29	NAADP	NAADP	NNP
cord-006229-7yoilsho	2750	30	concentration	concentration	NN
cord-006229-7yoilsho	2750	31	range	range	NN
cord-006229-7yoilsho	2750	32	.	.	.
cord-006229-7yoilsho	2751	1	Performing	perform	VBG
cord-006229-7yoilsho	2751	2	immungold	immungold	NN
cord-006229-7yoilsho	2751	3	-	-	HYPH
cord-006229-7yoilsho	2751	4	electron	electron	NN
cord-006229-7yoilsho	2751	5	microscopy	microscopy	NN
cord-006229-7yoilsho	2751	6	with	with	IN
cord-006229-7yoilsho	2751	7	a	a	DT
cord-006229-7yoilsho	2751	8	TPC1	TPC1	NNP
cord-006229-7yoilsho	2751	9	specific	specific	JJ
cord-006229-7yoilsho	2751	10	antibody	antibody	NN
cord-006229-7yoilsho	2751	11	,	,	,
cord-006229-7yoilsho	2751	12	a	a	DT
cord-006229-7yoilsho	2751	13	co	co	NN
cord-006229-7yoilsho	2751	14	-	-	NN
cord-006229-7yoilsho	2751	15	localization	localization	NN
cord-006229-7yoilsho	2751	16	with	with	IN
cord-006229-7yoilsho	2751	17	NAADP	naadp	NN
cord-006229-7yoilsho	2751	18	-	-	HYPH
cord-006229-7yoilsho	2751	19	binding	binding	NN
cord-006229-7yoilsho	2751	20	at	at	IN
cord-006229-7yoilsho	2751	21	the	the	DT
cord-006229-7yoilsho	2751	22	acrosomal	acrosomal	JJ
cord-006229-7yoilsho	2751	23	region	region	NN
cord-006229-7yoilsho	2751	24	was	be	VBD
cord-006229-7yoilsho	2751	25	detectable	detectable	JJ
cord-006229-7yoilsho	2751	26	.	.	.
cord-006229-7yoilsho	2752	1	Moreover	moreover	RB
cord-006229-7yoilsho	2752	2	,	,	,
cord-006229-7yoilsho	2752	3	quantifying	quantify	VBG
cord-006229-7yoilsho	2752	4	loss	loss	NN
cord-006229-7yoilsho	2752	5	of	of	IN
cord-006229-7yoilsho	2752	6	the	the	DT
cord-006229-7yoilsho	2752	7	acrosomal	acrosomal	JJ
cord-006229-7yoilsho	2752	8	vesicle	vesicle	NN
cord-006229-7yoilsho	2752	9	in	in	IN
cord-006229-7yoilsho	2752	10	TPC1	TPC1	NNP
cord-006229-7yoilsho	2752	11	null	null	JJ
cord-006229-7yoilsho	2752	12	sperm	sperm	NN
cord-006229-7yoilsho	2752	13	upon	upon	IN
cord-006229-7yoilsho	2752	14	application	application	NN
cord-006229-7yoilsho	2752	15	of	of	IN
cord-006229-7yoilsho	2752	16	different	different	JJ
cord-006229-7yoilsho	2752	17	NAADP	naadp	JJ
cord-006229-7yoilsho	2752	18	concentrations	concentration	NNS
cord-006229-7yoilsho	2752	19	,	,	,
cord-006229-7yoilsho	2752	20	responsiveness	responsiveness	NN
cord-006229-7yoilsho	2752	21	to	to	IN
cord-006229-7yoilsho	2752	22	low	low	JJ
cord-006229-7yoilsho	2752	23	micromolar	micromolar	JJ
cord-006229-7yoilsho	2752	24	NAADP	naadp	JJ
cord-006229-7yoilsho	2752	25	concentrations	concentration	NNS
cord-006229-7yoilsho	2752	26	was	be	VBD
cord-006229-7yoilsho	2752	27	completely	completely	RB
cord-006229-7yoilsho	2752	28	abolished	abolish	VBN
cord-006229-7yoilsho	2752	29	.	.	.
cord-006229-7yoilsho	2753	1	Conclusions	conclusion	NNS
cord-006229-7yoilsho	2753	2	/	/	SYM
cord-006229-7yoilsho	2753	3	Significance	significance	NN
cord-006229-7yoilsho	2753	4	:	:	:
cord-006229-7yoilsho	2754	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	2754	2	finding	finding	NN
cord-006229-7yoilsho	2754	3	that	that	IN
cord-006229-7yoilsho	2754	4	two	two	CD
cord-006229-7yoilsho	2754	5	convergent	convergent	JJ
cord-006229-7yoilsho	2754	6	NAADP	naadp	NN
cord-006229-7yoilsho	2754	7	-	-	HYPH
cord-006229-7yoilsho	2754	8	dependent	dependent	JJ
cord-006229-7yoilsho	2754	9	pathways	pathway	NNS
cord-006229-7yoilsho	2754	10	are	be	VBP
cord-006229-7yoilsho	2754	11	operative	operative	JJ
cord-006229-7yoilsho	2754	12	in	in	IN
cord-006229-7yoilsho	2754	13	driving	drive	VBG
cord-006229-7yoilsho	2754	14	acrosomal	acrosomal	JJ
cord-006229-7yoilsho	2754	15	exocytosis	exocytosis	NN
cord-006229-7yoilsho	2754	16	and	and	CC
cord-006229-7yoilsho	2754	17	that	that	IN
cord-006229-7yoilsho	2754	18	Zona	Zona	NNP
cord-006229-7yoilsho	2754	19	pellucida	pellucida	NN
cord-006229-7yoilsho	2754	20	induced	induce	VBN
cord-006229-7yoilsho	2754	21	acrosomal	acrosomal	VBG
cord-006229-7yoilsho	2754	22	exocytosis	exocytosis	NN
cord-006229-7yoilsho	2754	23	is	be	VBZ
cord-006229-7yoilsho	2754	24	prevented	prevent	VBN
cord-006229-7yoilsho	2754	25	by	by	IN
cord-006229-7yoilsho	2754	26	trans	trans	NNP
cord-006229-7yoilsho	2754	27	-	-	NNP
cord-006229-7yoilsho	2754	28	Ned-19	Ned-19	NNP
cord-006229-7yoilsho	2754	29	support	support	VBP
cord-006229-7yoilsho	2754	30	the	the	DT
cord-006229-7yoilsho	2754	31	concept	concept	NN
cord-006229-7yoilsho	2754	32	that	that	IN
cord-006229-7yoilsho	2754	33	both	both	CC
cord-006229-7yoilsho	2754	34	NAADP	naadp	RB
cord-006229-7yoilsho	2754	35	-	-	HYPH
cord-006229-7yoilsho	2754	36	gated	gate	VBN
cord-006229-7yoilsho	2754	37	cascades	cascade	NNS
cord-006229-7yoilsho	2754	38	match	match	VBP
cord-006229-7yoilsho	2754	39	local	local	JJ
cord-006229-7yoilsho	2754	40	NAADP	naadp	JJ
cord-006229-7yoilsho	2754	41	concentrations	concentration	NNS
cord-006229-7yoilsho	2754	42	with	with	IN
cord-006229-7yoilsho	2754	43	the	the	DT
cord-006229-7yoilsho	2754	44	efflux	efflux	NN
cord-006229-7yoilsho	2754	45	of	of	IN
cord-006229-7yoilsho	2754	46	acrosomal	acrosomal	JJ
cord-006229-7yoilsho	2754	47	calcium	calcium	NN
cord-006229-7yoilsho	2754	48	,	,	,
cord-006229-7yoilsho	2754	49	thereby	thereby	RB
cord-006229-7yoilsho	2754	50	ensuring	ensure	VBG
cord-006229-7yoilsho	2754	51	reliable	reliable	JJ
cord-006229-7yoilsho	2754	52	and	and	CC
cord-006229-7yoilsho	2754	53	complete	complete	JJ
cord-006229-7yoilsho	2754	54	fusion	fusion	NN
cord-006229-7yoilsho	2754	55	of	of	IN
cord-006229-7yoilsho	2754	56	the	the	DT
cord-006229-7yoilsho	2754	57	large	large	JJ
cord-006229-7yoilsho	2754	58	acrosomal	acrosomal	JJ
cord-006229-7yoilsho	2754	59	vesicle	vesicle	NN
cord-006229-7yoilsho	2754	60	.	.	.
cord-006229-7yoilsho	2755	1	Since	since	IN
cord-006229-7yoilsho	2755	2	the	the	DT
cord-006229-7yoilsho	2755	3	acrosome	acrosome	NNP
cord-006229-7yoilsho	2755	4	reaction	reaction	NN
cord-006229-7yoilsho	2755	5	shares	share	VBZ
cord-006229-7yoilsho	2755	6	the	the	DT
cord-006229-7yoilsho	2755	7	same	same	JJ
cord-006229-7yoilsho	2755	8	basic	basic	JJ
cord-006229-7yoilsho	2755	9	sequence	sequence	NN
cord-006229-7yoilsho	2755	10	of	of	IN
cord-006229-7yoilsho	2755	11	events	event	NNS
cord-006229-7yoilsho	2755	12	typical	typical	JJ
cord-006229-7yoilsho	2755	13	for	for	IN
cord-006229-7yoilsho	2755	14	the	the	DT
cord-006229-7yoilsho	2755	15	conserved	conserved	JJ
cord-006229-7yoilsho	2755	16	process	process	NN
cord-006229-7yoilsho	2755	17	of	of	IN
cord-006229-7yoilsho	2755	18	Calcium	calcium	NN
cord-006229-7yoilsho	2755	19	regulated	regulate	VBN
cord-006229-7yoilsho	2755	20	exocytosis	exocytosis	NN
cord-006229-7yoilsho	2755	21	,	,	,
cord-006229-7yoilsho	2755	22	such	such	JJ
cord-006229-7yoilsho	2755	23	as	as	IN
cord-006229-7yoilsho	2755	24	tethering	tethering	NN
cord-006229-7yoilsho	2755	25	,	,	,
cord-006229-7yoilsho	2755	26	docking	docking	NN
cord-006229-7yoilsho	2755	27	,	,	,
cord-006229-7yoilsho	2755	28	priming	priming	NN
cord-006229-7yoilsho	2755	29	and	and	CC
cord-006229-7yoilsho	2755	30	final	final	JJ
cord-006229-7yoilsho	2755	31	vesicle	vesicle	NN
cord-006229-7yoilsho	2755	32	fusion	fusion	NN
cord-006229-7yoilsho	2755	33	,	,	,
cord-006229-7yoilsho	2755	34	the	the	DT
cord-006229-7yoilsho	2755	35	sperm	sperm	NN
cord-006229-7yoilsho	2755	36	model	model	NN
cord-006229-7yoilsho	2755	37	system	system	NN
cord-006229-7yoilsho	2755	38	may	may	MD
cord-006229-7yoilsho	2755	39	also	also	RB
cord-006229-7yoilsho	2755	40	be	be	VB
cord-006229-7yoilsho	2755	41	useful	useful	JJ
cord-006229-7yoilsho	2755	42	to	to	TO
cord-006229-7yoilsho	2755	43	comparatively	comparatively	RB
cord-006229-7yoilsho	2755	44	examine	examine	VB
cord-006229-7yoilsho	2755	45	whether	whether	IN
cord-006229-7yoilsho	2755	46	the	the	DT
cord-006229-7yoilsho	2755	47	same	same	JJ
cord-006229-7yoilsho	2755	48	convergence	convergence	NN
cord-006229-7yoilsho	2755	49	of	of	IN
cord-006229-7yoilsho	2755	50	NAADP	naadp	JJ
cord-006229-7yoilsho	2755	51	-	-	HYPH
cord-006229-7yoilsho	2755	52	dependent	dependent	JJ
cord-006229-7yoilsho	2755	53	pathways	pathway	NNS
cord-006229-7yoilsho	2755	54	is	be	VBZ
cord-006229-7yoilsho	2755	55	also	also	RB
cord-006229-7yoilsho	2755	56	operative	operative	JJ
cord-006229-7yoilsho	2755	57	in	in	IN
cord-006229-7yoilsho	2755	58	cellular	cellular	JJ
cord-006229-7yoilsho	2755	59	systems	system	NNS
cord-006229-7yoilsho	2755	60	with	with	IN
cord-006229-7yoilsho	2755	61	many	many	JJ
cord-006229-7yoilsho	2755	62	secretory	secretory	JJ
cord-006229-7yoilsho	2755	63	vesicles	vesicle	NNS
cord-006229-7yoilsho	2755	64	.	.	.
cord-006229-7yoilsho	2756	1	Walther	Walther	NNP
cord-006229-7yoilsho	2756	2	-	-	HYPH
cord-006229-7yoilsho	2756	3	Straub	Straub	NNP
cord-006229-7yoilsho	2756	4	-	-	HYPH
cord-006229-7yoilsho	2756	5	Institut	Institut	NNP
cord-006229-7yoilsho	2756	6	,	,	,
cord-006229-7yoilsho	2756	7	München	München	NNP
cord-006229-7yoilsho	2756	8	,	,	,
cord-006229-7yoilsho	2756	9	Germany	Germany	NNP
cord-006229-7yoilsho	2756	10	TRPV4	TRPV4	NNP
cord-006229-7yoilsho	2756	11	channels	channel	NNS
cord-006229-7yoilsho	2756	12	are	be	VBP
cord-006229-7yoilsho	2756	13	members	member	NNS
cord-006229-7yoilsho	2756	14	of	of	IN
cord-006229-7yoilsho	2756	15	the	the	DT
cord-006229-7yoilsho	2756	16	vanilloid	vanilloid	NNP
cord-006229-7yoilsho	2756	17	family	family	NN
cord-006229-7yoilsho	2756	18	of	of	IN
cord-006229-7yoilsho	2756	19	TRP	TRP	NNP
cord-006229-7yoilsho	2756	20	proteins	protein	NNS
cord-006229-7yoilsho	2756	21	.	.	.
cord-006229-7yoilsho	2757	1	The	the	DT
cord-006229-7yoilsho	2757	2	channel	channel	NN
cord-006229-7yoilsho	2757	3	is	be	VBZ
cord-006229-7yoilsho	2757	4	nearly	nearly	RB
cord-006229-7yoilsho	2757	5	ubiquitously	ubiquitously	RB
cord-006229-7yoilsho	2757	6	expressed	express	VBN
cord-006229-7yoilsho	2757	7	and	and	CC
cord-006229-7yoilsho	2757	8	can	can	MD
cord-006229-7yoilsho	2757	9	be	be	VB
cord-006229-7yoilsho	2757	10	found	find	VBN
cord-006229-7yoilsho	2757	11	in	in	IN
cord-006229-7yoilsho	2757	12	brain	brain	NN
cord-006229-7yoilsho	2757	13	,	,	,
cord-006229-7yoilsho	2757	14	kidney	kidney	NN
cord-006229-7yoilsho	2757	15	,	,	,
cord-006229-7yoilsho	2757	16	skin	skin	NN
cord-006229-7yoilsho	2757	17	,	,	,
cord-006229-7yoilsho	2757	18	heart	heart	NN
cord-006229-7yoilsho	2757	19	,	,	,
cord-006229-7yoilsho	2757	20	blood	blood	NN
cord-006229-7yoilsho	2757	21	vessels	vessel	NNS
cord-006229-7yoilsho	2757	22	as	as	RB
cord-006229-7yoilsho	2757	23	well	well	RB
cord-006229-7yoilsho	2757	24	as	as	IN
cord-006229-7yoilsho	2757	25	in	in	IN
cord-006229-7yoilsho	2757	26	the	the	DT
cord-006229-7yoilsho	2757	27	lung	lung	NN
cord-006229-7yoilsho	2757	28	.	.	.
cord-006229-7yoilsho	2758	1	Pulmonary	pulmonary	JJ
cord-006229-7yoilsho	2758	2	expression	expression	NN
cord-006229-7yoilsho	2758	3	of	of	IN
cord-006229-7yoilsho	2758	4	TRPV4	trpv4	NN
cord-006229-7yoilsho	2758	5	has	have	VBZ
cord-006229-7yoilsho	2758	6	been	be	VBN
cord-006229-7yoilsho	2758	7	identified	identify	VBN
cord-006229-7yoilsho	2758	8	in	in	IN
cord-006229-7yoilsho	2758	9	endothelial	endothelial	JJ
cord-006229-7yoilsho	2758	10	cells	cell	NNS
cord-006229-7yoilsho	2758	11	(	(	-LRB-
cord-006229-7yoilsho	2758	12	1	1	CD
cord-006229-7yoilsho	2758	13	)	)	-RRB-
cord-006229-7yoilsho	2758	14	,	,	,
cord-006229-7yoilsho	2758	15	epithelial	epithelial	JJ
cord-006229-7yoilsho	2758	16	cells	cell	NNS
cord-006229-7yoilsho	2758	17	(	(	-LRB-
cord-006229-7yoilsho	2758	18	2	2	CD
cord-006229-7yoilsho	2758	19	)	)	-RRB-
cord-006229-7yoilsho	2758	20	and	and	CC
cord-006229-7yoilsho	2758	21	arterial	arterial	JJ
cord-006229-7yoilsho	2758	22	smooth	smooth	JJ
cord-006229-7yoilsho	2758	23	muscle	muscle	NN
cord-006229-7yoilsho	2758	24	cells	cell	NNS
cord-006229-7yoilsho	2758	25	(	(	-LRB-
cord-006229-7yoilsho	2758	26	3	3	CD
cord-006229-7yoilsho	2758	27	)	)	-RRB-
cord-006229-7yoilsho	2758	28	.	.	.
cord-006229-7yoilsho	2759	1	Most	most	RBS
cord-006229-7yoilsho	2759	2	interestingly	interestingly	RB
cord-006229-7yoilsho	2759	3	,	,	,
cord-006229-7yoilsho	2759	4	the	the	DT
cord-006229-7yoilsho	2759	5	channel	channel	NN
cord-006229-7yoilsho	2759	6	is	be	VBZ
cord-006229-7yoilsho	2759	7	known	know	VBN
cord-006229-7yoilsho	2759	8	to	to	TO
cord-006229-7yoilsho	2759	9	be	be	VB
cord-006229-7yoilsho	2759	10	involved	involve	VBN
cord-006229-7yoilsho	2759	11	in	in	IN
cord-006229-7yoilsho	2759	12	the	the	DT
cord-006229-7yoilsho	2759	13	development	development	NN
cord-006229-7yoilsho	2759	14	of	of	IN
cord-006229-7yoilsho	2759	15	several	several	JJ
cord-006229-7yoilsho	2759	16	lung	lung	NN
cord-006229-7yoilsho	2759	17	diseases	disease	NNS
cord-006229-7yoilsho	2759	18	such	such	JJ
cord-006229-7yoilsho	2759	19	as	as	IN
cord-006229-7yoilsho	2759	20	cough	cough	NN
cord-006229-7yoilsho	2759	21	,	,	,
cord-006229-7yoilsho	2759	22	asthma	asthma	NN
cord-006229-7yoilsho	2759	23	and	and	CC
cord-006229-7yoilsho	2759	24	pulmonary	pulmonary	JJ
cord-006229-7yoilsho	2759	25	edema	edema	NN
cord-006229-7yoilsho	2759	26	formation	formation	NN
cord-006229-7yoilsho	2759	27	,	,	,
cord-006229-7yoilsho	2759	28	due	due	IN
cord-006229-7yoilsho	2759	29	to	to	IN
cord-006229-7yoilsho	2759	30	its	-PRON-	PRP$
cord-006229-7yoilsho	2759	31	activation	activation	NN
cord-006229-7yoilsho	2759	32	by	by	IN
cord-006229-7yoilsho	2759	33	heat	heat	NN
cord-006229-7yoilsho	2759	34	,	,	,
cord-006229-7yoilsho	2759	35	changes	change	NNS
cord-006229-7yoilsho	2759	36	in	in	IN
cord-006229-7yoilsho	2759	37	osmolarity	osmolarity	NN
cord-006229-7yoilsho	2759	38	and	and	CC
cord-006229-7yoilsho	2759	39	shear	shear	NN
cord-006229-7yoilsho	2759	40	stress	stress	NN
cord-006229-7yoilsho	2759	41	(	(	-LRB-
cord-006229-7yoilsho	2759	42	reviewed	review	VBN
cord-006229-7yoilsho	2759	43	in	in	IN
cord-006229-7yoilsho	2759	44	4	4	CD
cord-006229-7yoilsho	2759	45	)	)	-RRB-
cord-006229-7yoilsho	2759	46	.	.	.
cord-006229-7yoilsho	2760	1	It	-PRON-	PRP
cord-006229-7yoilsho	2760	2	is	be	VBZ
cord-006229-7yoilsho	2760	3	a	a	DT
cord-006229-7yoilsho	2760	4	matter	matter	NN
cord-006229-7yoilsho	2760	5	of	of	IN
cord-006229-7yoilsho	2760	6	debate	debate	NN
cord-006229-7yoilsho	2760	7	however	however	RB
cord-006229-7yoilsho	2760	8	if	if	IN
cord-006229-7yoilsho	2760	9	TRPV4	trpv4	NN
cord-006229-7yoilsho	2760	10	activation	activation	NN
cord-006229-7yoilsho	2760	11	in	in	IN
cord-006229-7yoilsho	2760	12	pulmonary	pulmonary	JJ
cord-006229-7yoilsho	2760	13	endothelial	endothelial	NN
cord-006229-7yoilsho	2760	14	as	as	RB
cord-006229-7yoilsho	2760	15	well	well	RB
cord-006229-7yoilsho	2760	16	as	as	IN
cord-006229-7yoilsho	2760	17	epithelial	epithelial	JJ
cord-006229-7yoilsho	2760	18	cells	cell	NNS
cord-006229-7yoilsho	2760	19	induces	induce	VBZ
cord-006229-7yoilsho	2760	20	disruption	disruption	NN
cord-006229-7yoilsho	2760	21	of	of	IN
cord-006229-7yoilsho	2760	22	the	the	DT
cord-006229-7yoilsho	2760	23	barrier	barrier	NN
cord-006229-7yoilsho	2760	24	and	and	CC
cord-006229-7yoilsho	2760	25	an	an	DT
cord-006229-7yoilsho	2760	26	increased	increase	VBN
cord-006229-7yoilsho	2760	27	fluid	fluid	JJ
cord-006229-7yoilsho	2760	28	leak	leak	NN
cord-006229-7yoilsho	2760	29	into	into	IN
cord-006229-7yoilsho	2760	30	the	the	DT
cord-006229-7yoilsho	2760	31	alveolus	alveolus	NN
cord-006229-7yoilsho	2760	32	as	as	IN
cord-006229-7yoilsho	2760	33	described	describe	VBN
cord-006229-7yoilsho	2760	34	for	for	IN
cord-006229-7yoilsho	2760	35	TRPC6	TRPC6	NNP
cord-006229-7yoilsho	2760	36	(	(	-LRB-
cord-006229-7yoilsho	2760	37	5	5	CD
cord-006229-7yoilsho	2760	38	)	)	-RRB-
cord-006229-7yoilsho	2760	39	which	which	WDT
cord-006229-7yoilsho	2760	40	is	be	VBZ
cord-006229-7yoilsho	2760	41	also	also	RB
cord-006229-7yoilsho	2760	42	expressed	express	VBN
cord-006229-7yoilsho	2760	43	in	in	IN
cord-006229-7yoilsho	2760	44	both	both	DT
cord-006229-7yoilsho	2760	45	cell	cell	NN
cord-006229-7yoilsho	2760	46	types	type	NNS
cord-006229-7yoilsho	2760	47	.	.	.
cord-006229-7yoilsho	2761	1	To	to	TO
cord-006229-7yoilsho	2761	2	analyze	analyze	VB
cord-006229-7yoilsho	2761	3	the	the	DT
cord-006229-7yoilsho	2761	4	potential	potential	JJ
cord-006229-7yoilsho	2761	5	role	role	NN
cord-006229-7yoilsho	2761	6	of	of	IN
cord-006229-7yoilsho	2761	7	TRPV4	trpv4	NN
cord-006229-7yoilsho	2761	8	on	on	IN
cord-006229-7yoilsho	2761	9	ischemia	ischemia	NN
cord-006229-7yoilsho	2761	10	-	-	HYPH
cord-006229-7yoilsho	2761	11	reperfusion	reperfusion	NN
cord-006229-7yoilsho	2761	12	-	-	HYPH
cord-006229-7yoilsho	2761	13	injury(IRI)-induced	injury(iri)-induced	JJ
cord-006229-7yoilsho	2761	14	pulmonary	pulmonary	JJ
cord-006229-7yoilsho	2761	15	edema	edema	NN
cord-006229-7yoilsho	2761	16	formation	formation	NN
cord-006229-7yoilsho	2761	17	we	-PRON-	PRP
cord-006229-7yoilsho	2761	18	utilized	utilize	VBD
cord-006229-7yoilsho	2761	19	the	the	DT
cord-006229-7yoilsho	2761	20	isolated	isolated	JJ
cord-006229-7yoilsho	2761	21	perfused	perfuse	VBN
cord-006229-7yoilsho	2761	22	mouse	mouse	NN
cord-006229-7yoilsho	2761	23	lung	lung	NN
cord-006229-7yoilsho	2761	24	model	model	NN
cord-006229-7yoilsho	2761	25	.	.	.
cord-006229-7yoilsho	2762	1	Much	much	JJ
cord-006229-7yoilsho	2762	2	to	to	IN
cord-006229-7yoilsho	2762	3	our	-PRON-	PRP$
cord-006229-7yoilsho	2762	4	surprise	surprise	NN
cord-006229-7yoilsho	2762	5	,	,	,
cord-006229-7yoilsho	2762	6	we	-PRON-	PRP
cord-006229-7yoilsho	2762	7	detected	detect	VBD
cord-006229-7yoilsho	2762	8	a	a	DT
cord-006229-7yoilsho	2762	9	significantly	significantly	RB
cord-006229-7yoilsho	2762	10	enlarged	enlarge	VBN
cord-006229-7yoilsho	2762	11	edema	edema	NN
cord-006229-7yoilsho	2762	12	formation	formation	NN
cord-006229-7yoilsho	2762	13	after	after	IN
cord-006229-7yoilsho	2762	14	90	90	CD
cord-006229-7yoilsho	2762	15	minutes	minute	NNS
cord-006229-7yoilsho	2762	16	of	of	IN
cord-006229-7yoilsho	2762	17	ischemia	ischemia	NN
cord-006229-7yoilsho	2762	18	in	in	IN
cord-006229-7yoilsho	2762	19	TRPV4-deficient	TRPV4-deficient	NNP
cord-006229-7yoilsho	2762	20	mice	mouse	NNS
cord-006229-7yoilsho	2762	21	in	in	IN
cord-006229-7yoilsho	2762	22	comparison	comparison	NN
cord-006229-7yoilsho	2762	23	to	to	IN
cord-006229-7yoilsho	2762	24	wild	wild	JJ
cord-006229-7yoilsho	2762	25	-	-	HYPH
cord-006229-7yoilsho	2762	26	type	type	NN
cord-006229-7yoilsho	2762	27	(	(	-LRB-
cord-006229-7yoilsho	2762	28	WT	WT	NNP
cord-006229-7yoilsho	2762	29	)	)	-RRB-
cord-006229-7yoilsho	2762	30	mice	mouse	NNS
cord-006229-7yoilsho	2762	31	.	.	.
cord-006229-7yoilsho	2763	1	This	this	DT
cord-006229-7yoilsho	2763	2	effect	effect	NN
cord-006229-7yoilsho	2763	3	was	be	VBD
cord-006229-7yoilsho	2763	4	observed	observe	VBN
cord-006229-7yoilsho	2763	5	by	by	IN
cord-006229-7yoilsho	2763	6	constant	constant	JJ
cord-006229-7yoilsho	2763	7	weight	weight	NN
cord-006229-7yoilsho	2763	8	measurements	measurement	NNS
cord-006229-7yoilsho	2763	9	as	as	RB
cord-006229-7yoilsho	2763	10	well	well	RB
cord-006229-7yoilsho	2763	11	as	as	IN
cord-006229-7yoilsho	2763	12	wet	wet	JJ
cord-006229-7yoilsho	2763	13	-	-	HYPH
cord-006229-7yoilsho	2763	14	to	to	IN
cord-006229-7yoilsho	2763	15	-	-	HYPH
cord-006229-7yoilsho	2763	16	dry	dry	JJ
cord-006229-7yoilsho	2763	17	ratio	ratio	NN
cord-006229-7yoilsho	2763	18	gain	gain	NN
cord-006229-7yoilsho	2763	19	and	and	CC
cord-006229-7yoilsho	2763	20	was	be	VBD
cord-006229-7yoilsho	2763	21	not	not	RB
cord-006229-7yoilsho	2763	22	dependent	dependent	JJ
cord-006229-7yoilsho	2763	23	on	on	IN
cord-006229-7yoilsho	2763	24	the	the	DT
cord-006229-7yoilsho	2763	25	initial	initial	JJ
cord-006229-7yoilsho	2763	26	perfusion	perfusion	NN
cord-006229-7yoilsho	2763	27	rate	rate	NN
cord-006229-7yoilsho	2763	28	.	.	.
cord-006229-7yoilsho	2764	1	Most	most	RBS
cord-006229-7yoilsho	2764	2	interestingly	interestingly	RB
cord-006229-7yoilsho	2764	3	,	,	,
cord-006229-7yoilsho	2764	4	edema	edema	NN
cord-006229-7yoilsho	2764	5	formation	formation	NN
cord-006229-7yoilsho	2764	6	of	of	IN
cord-006229-7yoilsho	2764	7	TRPV4	TRPV4	NNP
cord-006229-7yoilsho	2764	8	/	/	SYM
cord-006229-7yoilsho	2764	9	TRPC6	TRPC6	NNP
cord-006229-7yoilsho	2764	10	double	double	JJ
cord-006229-7yoilsho	2764	11	deficient	deficient	JJ
cord-006229-7yoilsho	2764	12	lungs	lung	NNS
cord-006229-7yoilsho	2764	13	was	be	VBD
cord-006229-7yoilsho	2764	14	indistinguishable	indistinguishable	JJ
cord-006229-7yoilsho	2764	15	from	from	IN
cord-006229-7yoilsho	2764	16	WT	WT	NNP
cord-006229-7yoilsho	2764	17	lungs	lung	NNS
cord-006229-7yoilsho	2764	18	,	,	,
cord-006229-7yoilsho	2764	19	indicating	indicate	VBG
cord-006229-7yoilsho	2764	20	antagonizing	antagonize	VBG
cord-006229-7yoilsho	2764	21	effects	effect	NNS
cord-006229-7yoilsho	2764	22	of	of	IN
cord-006229-7yoilsho	2764	23	both	both	DT
cord-006229-7yoilsho	2764	24	channels	channel	NNS
cord-006229-7yoilsho	2764	25	,	,	,
cord-006229-7yoilsho	2764	26	because	because	IN
cord-006229-7yoilsho	2764	27	TRPC6	TRPC6	NNP
cord-006229-7yoilsho	2764	28	deficiency	deficiency	NN
cord-006229-7yoilsho	2764	29	protected	protect	VBD
cord-006229-7yoilsho	2764	30	lungs	lung	NNS
cord-006229-7yoilsho	2764	31	from	from	IN
cord-006229-7yoilsho	2764	32	IRI	IRI	NNP
cord-006229-7yoilsho	2764	33	-	-	HYPH
cord-006229-7yoilsho	2764	34	induced	induce	VBN
cord-006229-7yoilsho	2764	35	edema	edema	NN
cord-006229-7yoilsho	2764	36	(	(	-LRB-
cord-006229-7yoilsho	2764	37	5	5	CD
cord-006229-7yoilsho	2764	38	)	)	-RRB-
cord-006229-7yoilsho	2764	39	.	.	.
cord-006229-7yoilsho	2765	1	Moreover	moreover	RB
cord-006229-7yoilsho	2765	2	,	,	,
cord-006229-7yoilsho	2765	3	we	-PRON-	PRP
cord-006229-7yoilsho	2765	4	identified	identify	VBD
cord-006229-7yoilsho	2765	5	reduced	reduced	JJ
cord-006229-7yoilsho	2765	6	expression	expression	NN
cord-006229-7yoilsho	2765	7	levels	level	NNS
cord-006229-7yoilsho	2765	8	of	of	IN
cord-006229-7yoilsho	2765	9	aquaporin	aquaporin	NNP
cord-006229-7yoilsho	2765	10	5	5	CD
cord-006229-7yoilsho	2765	11	in	in	IN
cord-006229-7yoilsho	2765	12	TRPV4-deficient	TRPV4-deficient	NNP
cord-006229-7yoilsho	2765	13	lung	lung	NN
cord-006229-7yoilsho	2765	14	lysates	lysate	NNS
cord-006229-7yoilsho	2765	15	compared	compare	VBN
cord-006229-7yoilsho	2765	16	to	to	IN
cord-006229-7yoilsho	2765	17	WT	WT	NNP
cord-006229-7yoilsho	2765	18	lungs	lung	NNS
cord-006229-7yoilsho	2765	19	.	.	.
cord-006229-7yoilsho	2766	1	These	these	DT
cord-006229-7yoilsho	2766	2	findings	finding	NNS
cord-006229-7yoilsho	2766	3	raise	raise	VBP
cord-006229-7yoilsho	2766	4	the	the	DT
cord-006229-7yoilsho	2766	5	intriguing	intriguing	JJ
cord-006229-7yoilsho	2766	6	possibility	possibility	NN
cord-006229-7yoilsho	2766	7	that	that	IN
cord-006229-7yoilsho	2766	8	TRPV4	TRPV4	NNP
cord-006229-7yoilsho	2766	9	might	may	MD
cord-006229-7yoilsho	2766	10	be	be	VB
cord-006229-7yoilsho	2766	11	involved	involve	VBN
cord-006229-7yoilsho	2766	12	in	in	IN
cord-006229-7yoilsho	2766	13	the	the	DT
cord-006229-7yoilsho	2766	14	regulation	regulation	NN
cord-006229-7yoilsho	2766	15	of	of	IN
cord-006229-7yoilsho	2766	16	aquaporin	aquaporin	JJ
cord-006229-7yoilsho	2766	17	expression	expression	NN
cord-006229-7yoilsho	2766	18	in	in	IN
cord-006229-7yoilsho	2766	19	lung	lung	NN
cord-006229-7yoilsho	2766	20	endothelial	endothelial	NN
cord-006229-7yoilsho	2766	21	cells	cell	NNS
cord-006229-7yoilsho	2766	22	.	.	.
cord-006229-7yoilsho	2767	1	Endosomes	Endosomes	NNP
cord-006229-7yoilsho	2767	2	and	and	CC
cord-006229-7yoilsho	2767	3	lysosomes	lysosome	NNS
cord-006229-7yoilsho	2767	4	are	be	VBP
cord-006229-7yoilsho	2767	5	cell	cell	NN
cord-006229-7yoilsho	2767	6	organelles	organelle	NNS
cord-006229-7yoilsho	2767	7	involved	involve	VBN
cord-006229-7yoilsho	2767	8	in	in	IN
cord-006229-7yoilsho	2767	9	transport	transport	NN
cord-006229-7yoilsho	2767	10	,	,	,
cord-006229-7yoilsho	2767	11	breakdown	breakdown	NN
cord-006229-7yoilsho	2767	12	and	and	CC
cord-006229-7yoilsho	2767	13	secretion	secretion	NN
cord-006229-7yoilsho	2767	14	of	of	IN
cord-006229-7yoilsho	2767	15	proteins	protein	NNS
cord-006229-7yoilsho	2767	16	,	,	,
cord-006229-7yoilsho	2767	17	lipids	lipid	NNS
cord-006229-7yoilsho	2767	18	,	,	,
cord-006229-7yoilsho	2767	19	and	and	CC
cord-006229-7yoilsho	2767	20	other	other	JJ
cord-006229-7yoilsho	2767	21	macromolecules	macromolecule	NNS
cord-006229-7yoilsho	2767	22	.	.	.
cord-006229-7yoilsho	2768	1	Endolysosomal	endolysosomal	JJ
cord-006229-7yoilsho	2768	2	dysfunction	dysfunction	NN
cord-006229-7yoilsho	2768	3	can	can	MD
cord-006229-7yoilsho	2768	4	cause	cause	VB
cord-006229-7yoilsho	2768	5	storage	storage	NN
cord-006229-7yoilsho	2768	6	disorders	disorder	NNS
cord-006229-7yoilsho	2768	7	such	such	JJ
cord-006229-7yoilsho	2768	8	as	as	IN
cord-006229-7yoilsho	2768	9	mucolipidoses	mucolipidose	NNS
cord-006229-7yoilsho	2768	10	,	,	,
cord-006229-7yoilsho	2768	11	sphingolipidoses	sphingolipidose	NNS
cord-006229-7yoilsho	2768	12	,	,	,
cord-006229-7yoilsho	2768	13	or	or	CC
cord-006229-7yoilsho	2768	14	neuronal	neuronal	JJ
cord-006229-7yoilsho	2768	15	ceroid	ceroid	JJ
cord-006229-7yoilsho	2768	16	lipofuscinoses	lipofuscinose	NNS
cord-006229-7yoilsho	2768	17	,	,	,
cord-006229-7yoilsho	2768	18	but	but	CC
cord-006229-7yoilsho	2768	19	is	be	VBZ
cord-006229-7yoilsho	2768	20	also	also	RB
cord-006229-7yoilsho	2768	21	implicated	implicate	VBN
cord-006229-7yoilsho	2768	22	in	in	IN
cord-006229-7yoilsho	2768	23	the	the	DT
cord-006229-7yoilsho	2768	24	development	development	NN
cord-006229-7yoilsho	2768	25	of	of	IN
cord-006229-7yoilsho	2768	26	metabolic	metabolic	JJ
cord-006229-7yoilsho	2768	27	and	and	CC
cord-006229-7yoilsho	2768	28	neurodegenerative	neurodegenerative	JJ
cord-006229-7yoilsho	2768	29	diseases	disease	NNS
cord-006229-7yoilsho	2768	30	,	,	,
cord-006229-7yoilsho	2768	31	retinal	retinal	JJ
cord-006229-7yoilsho	2768	32	and	and	CC
cord-006229-7yoilsho	2768	33	pigmentation	pigmentation	NN
cord-006229-7yoilsho	2768	34	disorders	disorder	NNS
cord-006229-7yoilsho	2768	35	,	,	,
cord-006229-7yoilsho	2768	36	trace	trace	NN
cord-006229-7yoilsho	2768	37	metal	metal	NN
cord-006229-7yoilsho	2768	38	dishomeostasis	dishomeostasis	NN
cord-006229-7yoilsho	2768	39	,	,	,
cord-006229-7yoilsho	2768	40	infectious	infectious	JJ
cord-006229-7yoilsho	2768	41	diseases	disease	NNS
cord-006229-7yoilsho	2768	42	,	,	,
cord-006229-7yoilsho	2768	43	and	and	CC
cord-006229-7yoilsho	2768	44	cancer	cancer	NN
cord-006229-7yoilsho	2768	45	.	.	.
cord-006229-7yoilsho	2769	1	Endolysosomal	endolysosomal	JJ
cord-006229-7yoilsho	2769	2	ion	ion	NN
cord-006229-7yoilsho	2769	3	channels	channel	NNS
cord-006229-7yoilsho	2769	4	and	and	CC
cord-006229-7yoilsho	2769	5	transporters	transporter	NNS
cord-006229-7yoilsho	2769	6	are	be	VBP
cord-006229-7yoilsho	2769	7	highly	highly	RB
cord-006229-7yoilsho	2769	8	critical	critical	JJ
cord-006229-7yoilsho	2769	9	for	for	IN
cord-006229-7yoilsho	2769	10	the	the	DT
cord-006229-7yoilsho	2769	11	tight	tight	JJ
cord-006229-7yoilsho	2769	12	regulation	regulation	NN
cord-006229-7yoilsho	2769	13	of	of	IN
cord-006229-7yoilsho	2769	14	the	the	DT
cord-006229-7yoilsho	2769	15	multiple	multiple	JJ
cord-006229-7yoilsho	2769	16	endolysosomal	endolysosomal	JJ
cord-006229-7yoilsho	2769	17	fusion	fusion	NN
cord-006229-7yoilsho	2769	18	and	and	CC
cord-006229-7yoilsho	2769	19	fission	fission	NN
cord-006229-7yoilsho	2769	20	processes	process	NNS
cord-006229-7yoilsho	2769	21	including	include	VBG
cord-006229-7yoilsho	2769	22	endo	endo	NN
cord-006229-7yoilsho	2769	23	-	-	HYPH
cord-006229-7yoilsho	2769	24	and	and	CC
cord-006229-7yoilsho	2769	25	exocytotic	exocytotic	JJ
cord-006229-7yoilsho	2769	26	events	event	NNS
cord-006229-7yoilsho	2769	27	as	as	RB
cord-006229-7yoilsho	2769	28	well	well	RB
cord-006229-7yoilsho	2769	29	as	as	IN
cord-006229-7yoilsho	2769	30	the	the	DT
cord-006229-7yoilsho	2769	31	regulation	regulation	NN
cord-006229-7yoilsho	2769	32	of	of	IN
cord-006229-7yoilsho	2769	33	proton	proton	NN
cord-006229-7yoilsho	2769	34	and	and	CC
cord-006229-7yoilsho	2769	35	other	other	JJ
cord-006229-7yoilsho	2769	36	ionic	ionic	JJ
cord-006229-7yoilsho	2769	37	concentrations	concentration	NNS
cord-006229-7yoilsho	2769	38	in	in	IN
cord-006229-7yoilsho	2769	39	the	the	DT
cord-006229-7yoilsho	2769	40	lumen	lumen	NN
cord-006229-7yoilsho	2769	41	of	of	IN
cord-006229-7yoilsho	2769	42	endolysosomal	endolysosomal	JJ
cord-006229-7yoilsho	2769	43	vesicles	vesicle	NNS
cord-006229-7yoilsho	2769	44	.	.	.
cord-006229-7yoilsho	2770	1	Methods	method	NNS
cord-006229-7yoilsho	2770	2	to	to	IN
cord-006229-7yoilsho	2770	3	patch	patch	VB
cord-006229-7yoilsho	2770	4	-	-	HYPH
cord-006229-7yoilsho	2770	5	clamp	clamp	NN
cord-006229-7yoilsho	2770	6	endolysosomal	endolysosomal	JJ
cord-006229-7yoilsho	2770	7	organelles	organelle	NNS
cord-006229-7yoilsho	2770	8	are	be	VBP
cord-006229-7yoilsho	2770	9	continuously	continuously	RB
cord-006229-7yoilsho	2770	10	improving	improve	VBG
cord-006229-7yoilsho	2770	11	.	.	.
cord-006229-7yoilsho	2771	1	Yet	yet	CC
cord-006229-7yoilsho	2771	2	until	until	IN
cord-006229-7yoilsho	2771	3	now	now	RB
cord-006229-7yoilsho	2771	4	it	-PRON-	PRP
cord-006229-7yoilsho	2771	5	has	have	VBZ
cord-006229-7yoilsho	2771	6	not	not	RB
cord-006229-7yoilsho	2771	7	been	be	VBN
cord-006229-7yoilsho	2771	8	possible	possible	JJ
cord-006229-7yoilsho	2771	9	to	to	TO
cord-006229-7yoilsho	2771	10	selectively	selectively	RB
cord-006229-7yoilsho	2771	11	enlarge	enlarge	VB
cord-006229-7yoilsho	2771	12	endosomal	endosomal	NNP
cord-006229-7yoilsho	2771	13	or	or	CC
cord-006229-7yoilsho	2771	14	lysosomal	lysosomal	JJ
cord-006229-7yoilsho	2771	15	organelles	organelle	NNS
cord-006229-7yoilsho	2771	16	with	with	IN
cord-006229-7yoilsho	2771	17	pharmacological	pharmacological	JJ
cord-006229-7yoilsho	2771	18	tools	tool	NNS
cord-006229-7yoilsho	2771	19	for	for	IN
cord-006229-7yoilsho	2771	20	patch	patch	NN
cord-006229-7yoilsho	2771	21	-	-	HYPH
cord-006229-7yoilsho	2771	22	clamp	clamp	NN
cord-006229-7yoilsho	2771	23	experimentation	experimentation	NN
cord-006229-7yoilsho	2771	24	.	.	.
cord-006229-7yoilsho	2772	1	We	-PRON-	PRP
cord-006229-7yoilsho	2772	2	show	show	VBP
cord-006229-7yoilsho	2772	3	here	here	RB
cord-006229-7yoilsho	2772	4	by	by	IN
cord-006229-7yoilsho	2772	5	using	use	VBG
cord-006229-7yoilsho	2772	6	a	a	DT
cord-006229-7yoilsho	2772	7	combination	combination	NN
cord-006229-7yoilsho	2772	8	of	of	IN
cord-006229-7yoilsho	2772	9	two	two	CD
cord-006229-7yoilsho	2772	10	small	small	JJ
cord-006229-7yoilsho	2772	11	molecules	molecule	NNS
cord-006229-7yoilsho	2772	12	that	that	WDT
cord-006229-7yoilsho	2772	13	we	-PRON-	PRP
cord-006229-7yoilsho	2772	14	can	can	MD
cord-006229-7yoilsho	2772	15	selectively	selectively	RB
cord-006229-7yoilsho	2772	16	enlarge	enlarge	VB
cord-006229-7yoilsho	2772	17	early	early	JJ
cord-006229-7yoilsho	2772	18	endosomes	endosome	NNS
cord-006229-7yoilsho	2772	19	to	to	IN
cord-006229-7yoilsho	2772	20	a	a	DT
cord-006229-7yoilsho	2772	21	degree	degree	NN
cord-006229-7yoilsho	2772	22	sufficient	sufficient	JJ
cord-006229-7yoilsho	2772	23	for	for	IN
cord-006229-7yoilsho	2772	24	patch	patch	NN
cord-006229-7yoilsho	2772	25	-	-	HYPH
cord-006229-7yoilsho	2772	26	clamp	clamp	NN
cord-006229-7yoilsho	2772	27	experimentation	experimentation	NN
cord-006229-7yoilsho	2772	28	.	.	.
cord-006229-7yoilsho	2773	1	The	the	DT
cord-006229-7yoilsho	2773	2	ability	ability	NN
cord-006229-7yoilsho	2773	3	to	to	TO
cord-006229-7yoilsho	2773	4	more	more	RBR
cord-006229-7yoilsho	2773	5	selectively	selectively	RB
cord-006229-7yoilsho	2773	6	patch	patch	NN
cord-006229-7yoilsho	2773	7	-	-	HYPH
cord-006229-7yoilsho	2773	8	clamp	clamp	NN
cord-006229-7yoilsho	2773	9	intracellular	intracellular	JJ
cord-006229-7yoilsho	2773	10	organelles	organelle	NNS
cord-006229-7yoilsho	2773	11	will	will	MD
cord-006229-7yoilsho	2773	12	substantially	substantially	RB
cord-006229-7yoilsho	2773	13	improve	improve	VB
cord-006229-7yoilsho	2773	14	the	the	DT
cord-006229-7yoilsho	2773	15	functional	functional	JJ
cord-006229-7yoilsho	2773	16	investigation	investigation	NN
cord-006229-7yoilsho	2773	17	of	of	IN
cord-006229-7yoilsho	2773	18	endolysosomal	endolysosomal	JJ
cord-006229-7yoilsho	2773	19	ion	ion	NN
cord-006229-7yoilsho	2773	20	channels	channel	NNS
cord-006229-7yoilsho	2773	21	under	under	IN
cord-006229-7yoilsho	2773	22	physiological	physiological	JJ
cord-006229-7yoilsho	2773	23	and	and	CC
cord-006229-7yoilsho	2773	24	pathophysiological	pathophysiological	JJ
cord-006229-7yoilsho	2773	25	conditions	condition	NNS
cord-006229-7yoilsho	2773	26	.	.	.
cord-006229-7yoilsho	2774	1	The	the	DT
cord-006229-7yoilsho	2774	2	transient	transient	JJ
cord-006229-7yoilsho	2774	3	receptor	receptor	NN
cord-006229-7yoilsho	2774	4	potential	potential	NN
cord-006229-7yoilsho	2774	5	(	(	-LRB-
cord-006229-7yoilsho	2774	6	TRP	TRP	NNP
cord-006229-7yoilsho	2774	7	)	)	-RRB-
cord-006229-7yoilsho	2774	8	channels	channel	NNS
cord-006229-7yoilsho	2774	9	are	be	VBP
cord-006229-7yoilsho	2774	10	a	a	DT
cord-006229-7yoilsho	2774	11	superfamily	superfamily	NN
cord-006229-7yoilsho	2774	12	of	of	IN
cord-006229-7yoilsho	2774	13	non	non	JJ
cord-006229-7yoilsho	2774	14	-	-	JJ
cord-006229-7yoilsho	2774	15	selective	selective	JJ
cord-006229-7yoilsho	2774	16	ion	ion	NN
cord-006229-7yoilsho	2774	17	channels	channel	NNS
cord-006229-7yoilsho	2774	18	involved	involve	VBN
cord-006229-7yoilsho	2774	19	in	in	IN
cord-006229-7yoilsho	2774	20	a	a	DT
cord-006229-7yoilsho	2774	21	variety	variety	NN
cord-006229-7yoilsho	2774	22	of	of	IN
cord-006229-7yoilsho	2774	23	physiological	physiological	JJ
cord-006229-7yoilsho	2774	24	processes	process	NNS
cord-006229-7yoilsho	2774	25	and	and	CC
cord-006229-7yoilsho	2774	26	in	in	IN
cord-006229-7yoilsho	2774	27	the	the	DT
cord-006229-7yoilsho	2774	28	pathgenesis	pathgenesis	NN
cord-006229-7yoilsho	2774	29	of	of	IN
cord-006229-7yoilsho	2774	30	many	many	JJ
cord-006229-7yoilsho	2774	31	disorders	disorder	NNS
cord-006229-7yoilsho	2774	32	.	.	.
cord-006229-7yoilsho	2775	1	In	in	IN
cord-006229-7yoilsho	2775	2	the	the	DT
cord-006229-7yoilsho	2775	3	kidney	kidney	NN
cord-006229-7yoilsho	2775	4	,	,	,
cord-006229-7yoilsho	2775	5	TRP	trp	NN
cord-006229-7yoilsho	2775	6	channels	channel	NNS
cord-006229-7yoilsho	2775	7	have	have	VBP
cord-006229-7yoilsho	2775	8	been	be	VBN
cord-006229-7yoilsho	2775	9	implicated	implicate	VBN
cord-006229-7yoilsho	2775	10	to	to	TO
cord-006229-7yoilsho	2775	11	be	be	VB
cord-006229-7yoilsho	2775	12	involved	involve	VBN
cord-006229-7yoilsho	2775	13	in	in	IN
cord-006229-7yoilsho	2775	14	diabetic	diabetic	JJ
cord-006229-7yoilsho	2775	15	nephropathy	nephropathy	NN
cord-006229-7yoilsho	2775	16	,	,	,
cord-006229-7yoilsho	2775	17	focal	focal	JJ
cord-006229-7yoilsho	2775	18	,	,	,
cord-006229-7yoilsho	2775	19	segmental	segmental	JJ
cord-006229-7yoilsho	2775	20	glomerulosclerosis	glomerulosclerosis	NN
cord-006229-7yoilsho	2775	21	,	,	,
cord-006229-7yoilsho	2775	22	polycystic	polycystic	JJ
cord-006229-7yoilsho	2775	23	kidney	kidney	NN
cord-006229-7yoilsho	2775	24	disease	disease	NN
cord-006229-7yoilsho	2775	25	,	,	,
cord-006229-7yoilsho	2775	26	hypomagnesemia	hypomagnesemia	NN
cord-006229-7yoilsho	2775	27	with	with	IN
cord-006229-7yoilsho	2775	28	secondary	secondary	JJ
cord-006229-7yoilsho	2775	29	hypercalcemia	hypercalcemia	NN
cord-006229-7yoilsho	2775	30	and	and	CC
cord-006229-7yoilsho	2775	31	idiopathic	idiopathic	JJ
cord-006229-7yoilsho	2775	32	hypercalcuria	hypercalcuria	NNP
cord-006229-7yoilsho	2775	33	.	.	.
cord-006229-7yoilsho	2776	1	The	the	DT
cord-006229-7yoilsho	2776	2	melastatin	melastatin	NNS
cord-006229-7yoilsho	2776	3	-	-	HYPH
cord-006229-7yoilsho	2776	4	like	like	JJ
cord-006229-7yoilsho	2776	5	TRP	TRP	NNP
cord-006229-7yoilsho	2776	6	channel	channel	NN
cord-006229-7yoilsho	2776	7	subfamily	subfamily	NN
cord-006229-7yoilsho	2776	8	3	3	CD
cord-006229-7yoilsho	2776	9	(	(	-LRB-
cord-006229-7yoilsho	2776	10	TRPM3	TRPM3	NNP
cord-006229-7yoilsho	2776	11	)	)	-RRB-
cord-006229-7yoilsho	2776	12	has	have	VBZ
cord-006229-7yoilsho	2776	13	been	be	VBN
cord-006229-7yoilsho	2776	14	shown	show	VBN
cord-006229-7yoilsho	2776	15	to	to	TO
cord-006229-7yoilsho	2776	16	be	be	VB
cord-006229-7yoilsho	2776	17	expressed	express	VBN
cord-006229-7yoilsho	2776	18	in	in	IN
cord-006229-7yoilsho	2776	19	human	human	JJ
cord-006229-7yoilsho	2776	20	kidney	kidney	NN
cord-006229-7yoilsho	2776	21	1	1	CD
cord-006229-7yoilsho	2776	22	,	,	,
cord-006229-7yoilsho	2776	23	2	2	CD
cord-006229-7yoilsho	2776	24	.	.	.
cord-006229-7yoilsho	2777	1	Using	use	VBG
cord-006229-7yoilsho	2777	2	newly	newly	RB
cord-006229-7yoilsho	2777	3	developed	develop	VBN
cord-006229-7yoilsho	2777	4	anti	anti	NN
cord-006229-7yoilsho	2777	5	-	-	JJ
cord-006229-7yoilsho	2777	6	TRPM3	trpm3	JJ
cord-006229-7yoilsho	2777	7	antibodies	antibody	NNS
cord-006229-7yoilsho	2777	8	,	,	,
cord-006229-7yoilsho	2777	9	we	-PRON-	PRP
cord-006229-7yoilsho	2777	10	are	be	VBP
cord-006229-7yoilsho	2777	11	able	able	JJ
cord-006229-7yoilsho	2777	12	to	to	TO
cord-006229-7yoilsho	2777	13	visualize	visualize	VB
cord-006229-7yoilsho	2777	14	TRPM3	TRPM3	NNP
cord-006229-7yoilsho	2777	15	protein	protein	NN
cord-006229-7yoilsho	2777	16	in	in	IN
cord-006229-7yoilsho	2777	17	epithelial	epithelial	JJ
cord-006229-7yoilsho	2777	18	cells	cell	NNS
cord-006229-7yoilsho	2777	19	of	of	IN
cord-006229-7yoilsho	2777	20	proximal	proximal	JJ
cord-006229-7yoilsho	2777	21	tubule	tubule	NN
cord-006229-7yoilsho	2777	22	as	as	RB
cord-006229-7yoilsho	2777	23	well	well	RB
cord-006229-7yoilsho	2777	24	as	as	IN
cord-006229-7yoilsho	2777	25	collecting	collect	VBG
cord-006229-7yoilsho	2777	26	ducts	duct	NNS
cord-006229-7yoilsho	2777	27	in	in	IN
cord-006229-7yoilsho	2777	28	the	the	DT
cord-006229-7yoilsho	2777	29	mouse	mouse	NN
cord-006229-7yoilsho	2777	30	kidneys	kidney	NNS
cord-006229-7yoilsho	2777	31	.	.	.
cord-006229-7yoilsho	2778	1	Therefore	therefore	RB
cord-006229-7yoilsho	2778	2	,	,	,
cord-006229-7yoilsho	2778	3	we	-PRON-	PRP
cord-006229-7yoilsho	2778	4	compared	compare	VBD
cord-006229-7yoilsho	2778	5	renal	renal	JJ
cord-006229-7yoilsho	2778	6	function	function	NN
cord-006229-7yoilsho	2778	7	of	of	IN
cord-006229-7yoilsho	2778	8	male	male	NN
cord-006229-7yoilsho	2778	9	,	,	,
cord-006229-7yoilsho	2778	10	five	five	CD
cord-006229-7yoilsho	2778	11	month	month	NN
cord-006229-7yoilsho	2778	12	old	old	JJ
cord-006229-7yoilsho	2778	13	mice	mouse	NNS
cord-006229-7yoilsho	2778	14	lacking	lack	VBG
cord-006229-7yoilsho	2778	15	TRPM3	TRPM3	.
cord-006229-7yoilsho	2779	1	(	(	-LRB-
cord-006229-7yoilsho	2779	2	TRPM3	trpm3	XX
cord-006229-7yoilsho	2780	1	The	the	DT
cord-006229-7yoilsho	2780	2	ATP	ATP	NNP
cord-006229-7yoilsho	2780	3	-	-	HYPH
cord-006229-7yoilsho	2780	4	gated	gate	VBN
cord-006229-7yoilsho	2780	5	P2X7	P2X7	NNP
cord-006229-7yoilsho	2780	6	receptor	receptor	NN
cord-006229-7yoilsho	2780	7	(	(	-LRB-
cord-006229-7yoilsho	2780	8	P2X7R	P2X7R	NNP
cord-006229-7yoilsho	2780	9	)	)	-RRB-
cord-006229-7yoilsho	2780	10	is	be	VBZ
cord-006229-7yoilsho	2780	11	a	a	DT
cord-006229-7yoilsho	2780	12	non	non	JJ
cord-006229-7yoilsho	2780	13	-	-	JJ
cord-006229-7yoilsho	2780	14	selective	selective	JJ
cord-006229-7yoilsho	2780	15	cation	cation	NN
cord-006229-7yoilsho	2780	16	channel	channel	NN
cord-006229-7yoilsho	2780	17	widely	widely	RB
cord-006229-7yoilsho	2780	18	expressed	express	VBN
cord-006229-7yoilsho	2780	19	in	in	IN
cord-006229-7yoilsho	2780	20	epithelia	epithelium	NNS
cord-006229-7yoilsho	2780	21	,	,	,
cord-006229-7yoilsho	2780	22	endothelia	endothelia	NNP
cord-006229-7yoilsho	2780	23	,	,	,
cord-006229-7yoilsho	2780	24	and	and	CC
cord-006229-7yoilsho	2780	25	cells	cell	NNS
cord-006229-7yoilsho	2780	26	of	of	IN
cord-006229-7yoilsho	2780	27	hematopoietic	hematopoietic	JJ
cord-006229-7yoilsho	2780	28	origin	origin	NN
cord-006229-7yoilsho	2780	29	.	.	.
cord-006229-7yoilsho	2781	1	It	-PRON-	PRP
cord-006229-7yoilsho	2781	2	plays	play	VBZ
cord-006229-7yoilsho	2781	3	a	a	DT
cord-006229-7yoilsho	2781	4	central	central	JJ
cord-006229-7yoilsho	2781	5	role	role	NN
cord-006229-7yoilsho	2781	6	in	in	IN
cord-006229-7yoilsho	2781	7	cytokine	cytokine	NN
cord-006229-7yoilsho	2781	8	release	release	NN
cord-006229-7yoilsho	2781	9	and	and	CC
cord-006229-7yoilsho	2781	10	studies	study	NNS
cord-006229-7yoilsho	2781	11	in	in	IN
cord-006229-7yoilsho	2781	12	P2X7	P2X7	NNP
cord-006229-7yoilsho	2781	13	-/animals	-/animal	NNS
cord-006229-7yoilsho	2781	14	indicate	indicate	VBP
cord-006229-7yoilsho	2781	15	its	-PRON-	PRP$
cord-006229-7yoilsho	2781	16	involvement	involvement	NN
cord-006229-7yoilsho	2781	17	in	in	IN
cord-006229-7yoilsho	2781	18	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	2781	19	and	and	CC
cord-006229-7yoilsho	2781	20	neurodegenerative	neurodegenerative	JJ
cord-006229-7yoilsho	2781	21	diseases	disease	NNS
cord-006229-7yoilsho	2781	22	.	.	.
cord-006229-7yoilsho	2782	1	In	in	IN
cord-006229-7yoilsho	2782	2	addition	addition	NN
cord-006229-7yoilsho	2782	3	,	,	,
cord-006229-7yoilsho	2782	4	accumulating	accumulate	VBG
cord-006229-7yoilsho	2782	5	data	datum	NNS
cord-006229-7yoilsho	2782	6	suggests	suggest	VBZ
cord-006229-7yoilsho	2782	7	a	a	DT
cord-006229-7yoilsho	2782	8	functional	functional	JJ
cord-006229-7yoilsho	2782	9	role	role	NN
cord-006229-7yoilsho	2782	10	in	in	IN
cord-006229-7yoilsho	2782	11	neurons	neuron	NNS
cord-006229-7yoilsho	2782	12	and	and	CC
cord-006229-7yoilsho	2782	13	its	-PRON-	PRP$
cord-006229-7yoilsho	2782	14	involvement	involvement	NN
cord-006229-7yoilsho	2782	15	in	in	IN
cord-006229-7yoilsho	2782	16	neurotransmitter	neurotransmitter	NN
cord-006229-7yoilsho	2782	17	release	release	NN
cord-006229-7yoilsho	2782	18	in	in	IN
cord-006229-7yoilsho	2782	19	the	the	DT
cord-006229-7yoilsho	2782	20	brain	brain	NN
cord-006229-7yoilsho	2782	21	.	.	.
cord-006229-7yoilsho	2783	1	However	however	RB
cord-006229-7yoilsho	2783	2	,	,	,
cord-006229-7yoilsho	2783	3	despite	despite	IN
cord-006229-7yoilsho	2783	4	its	-PRON-	PRP$
cord-006229-7yoilsho	2783	5	importance	importance	NN
cord-006229-7yoilsho	2783	6	as	as	IN
cord-006229-7yoilsho	2783	7	a	a	DT
cord-006229-7yoilsho	2783	8	drug	drug	NN
cord-006229-7yoilsho	2783	9	target	target	NN
cord-006229-7yoilsho	2783	10	,	,	,
cord-006229-7yoilsho	2783	11	its	-PRON-	PRP$
cord-006229-7yoilsho	2783	12	precise	precise	JJ
cord-006229-7yoilsho	2783	13	localization	localization	NN
cord-006229-7yoilsho	2783	14	and	and	CC
cord-006229-7yoilsho	2783	15	its	-PRON-	PRP$
cord-006229-7yoilsho	2783	16	molecular	molecular	JJ
cord-006229-7yoilsho	2783	17	and	and	CC
cord-006229-7yoilsho	2783	18	physiological	physiological	JJ
cord-006229-7yoilsho	2783	19	functions	function	NNS
cord-006229-7yoilsho	2783	20	remain	remain	VBP
cord-006229-7yoilsho	2783	21	poorly	poorly	RB
cord-006229-7yoilsho	2783	22	understood	understand	VBN
cord-006229-7yoilsho	2783	23	.	.	.
cord-006229-7yoilsho	2784	1	In	in	IN
cord-006229-7yoilsho	2784	2	particular	particular	JJ
cord-006229-7yoilsho	2784	3	,	,	,
cord-006229-7yoilsho	2784	4	the	the	DT
cord-006229-7yoilsho	2784	5	location	location	NN
cord-006229-7yoilsho	2784	6	and	and	CC
cord-006229-7yoilsho	2784	7	function	function	NN
cord-006229-7yoilsho	2784	8	of	of	IN
cord-006229-7yoilsho	2784	9	P2X7R	P2X7R	NNP
cord-006229-7yoilsho	2784	10	in	in	IN
cord-006229-7yoilsho	2784	11	neurons	neuron	NNS
cord-006229-7yoilsho	2784	12	remain	remain	VBP
cord-006229-7yoilsho	2784	13	a	a	DT
cord-006229-7yoilsho	2784	14	matter	matter	NN
cord-006229-7yoilsho	2784	15	of	of	IN
cord-006229-7yoilsho	2784	16	ongoing	ongoing	JJ
cord-006229-7yoilsho	2784	17	debate	debate	NN
cord-006229-7yoilsho	2784	18	.	.	.
cord-006229-7yoilsho	2785	1	To	to	TO
cord-006229-7yoilsho	2785	2	clarify	clarify	VB
cord-006229-7yoilsho	2785	3	the	the	DT
cord-006229-7yoilsho	2785	4	cellular	cellular	JJ
cord-006229-7yoilsho	2785	5	and	and	CC
cord-006229-7yoilsho	2785	6	subcellular	subcellular	JJ
cord-006229-7yoilsho	2785	7	distribution	distribution	NN
cord-006229-7yoilsho	2785	8	of	of	IN
cord-006229-7yoilsho	2785	9	the	the	DT
cord-006229-7yoilsho	2785	10	P2X7R	P2X7R	NNP
cord-006229-7yoilsho	2785	11	and	and	CC
cord-006229-7yoilsho	2785	12	to	to	TO
cord-006229-7yoilsho	2785	13	investigate	investigate	VB
cord-006229-7yoilsho	2785	14	its	-PRON-	PRP$
cord-006229-7yoilsho	2785	15	physiological	physiological	JJ
cord-006229-7yoilsho	2785	16	and	and	CC
cord-006229-7yoilsho	2785	17	pathophysiological	pathophysiological	JJ
cord-006229-7yoilsho	2785	18	role	role	NN
cord-006229-7yoilsho	2785	19	in	in	IN
cord-006229-7yoilsho	2785	20	the	the	DT
cord-006229-7yoilsho	2785	21	brain	brain	NN
cord-006229-7yoilsho	2785	22	we	-PRON-	PRP
cord-006229-7yoilsho	2785	23	generated	generate	VBD
cord-006229-7yoilsho	2785	24	BAC	BAC	NNP
cord-006229-7yoilsho	2785	25	transgenic	transgenic	JJ
cord-006229-7yoilsho	2785	26	mouse	mouse	NN
cord-006229-7yoilsho	2785	27	models	model	NNS
cord-006229-7yoilsho	2785	28	in	in	IN
cord-006229-7yoilsho	2785	29	which	which	WDT
cord-006229-7yoilsho	2785	30	murine	murine	JJ
cord-006229-7yoilsho	2785	31	polymorphic	polymorphic	JJ
cord-006229-7yoilsho	2785	32	variants	variant	NNS
cord-006229-7yoilsho	2785	33	of	of	IN
cord-006229-7yoilsho	2785	34	EGFP	EGFP	NNP
cord-006229-7yoilsho	2785	35	-	-	HYPH
cord-006229-7yoilsho	2785	36	tagged	tag	VBN
cord-006229-7yoilsho	2785	37	P2X7R	P2X7R	NNP
cord-006229-7yoilsho	2785	38	are	be	VBP
cord-006229-7yoilsho	2785	39	overexpressed	overexpresse	VBN
cord-006229-7yoilsho	2785	40	under	under	IN
cord-006229-7yoilsho	2785	41	the	the	DT
cord-006229-7yoilsho	2785	42	control	control	NN
cord-006229-7yoilsho	2785	43	of	of	IN
cord-006229-7yoilsho	2785	44	the	the	DT
cord-006229-7yoilsho	2785	45	endogenous	endogenous	JJ
cord-006229-7yoilsho	2785	46	P2X7	P2X7	NNP
cord-006229-7yoilsho	2785	47	promoter	promoter	NN
cord-006229-7yoilsho	2785	48	.	.	.
cord-006229-7yoilsho	2786	1	The	the	DT
cord-006229-7yoilsho	2786	2	EGFP	EGFP	NNP
cord-006229-7yoilsho	2786	3	-	-	HYPH
cord-006229-7yoilsho	2786	4	tagged	tagged	NNP
cord-006229-7yoilsho	2786	5	P2X7Rs	P2X7Rs	NNP
cord-006229-7yoilsho	2786	6	are	be	VBP
cord-006229-7yoilsho	2786	7	efficiently	efficiently	RB
cord-006229-7yoilsho	2786	8	overexpressed	overexpresse	VBN
cord-006229-7yoilsho	2786	9	in	in	IN
cord-006229-7yoilsho	2786	10	the	the	DT
cord-006229-7yoilsho	2786	11	plasma	plasma	NN
cord-006229-7yoilsho	2786	12	membrane	membrane	NN
cord-006229-7yoilsho	2786	13	and	and	CC
cord-006229-7yoilsho	2786	14	can	can	MD
cord-006229-7yoilsho	2786	15	be	be	VB
cord-006229-7yoilsho	2786	16	directly	directly	RB
cord-006229-7yoilsho	2786	17	visualized	visualize	VBN
cord-006229-7yoilsho	2786	18	by	by	IN
cord-006229-7yoilsho	2786	19	green	green	JJ
cord-006229-7yoilsho	2786	20	fluorescence	fluorescence	NN
cord-006229-7yoilsho	2786	21	or	or	CC
cord-006229-7yoilsho	2786	22	indirectly	indirectly	RB
cord-006229-7yoilsho	2786	23	by	by	IN
cord-006229-7yoilsho	2786	24	anti	anti	JJ
cord-006229-7yoilsho	2786	25	-	-	JJ
cord-006229-7yoilsho	2786	26	EGFP	egfp	JJ
cord-006229-7yoilsho	2786	27	antibodies	antibody	NNS
cord-006229-7yoilsho	2786	28	.	.	.
cord-006229-7yoilsho	2787	1	The	the	DT
cord-006229-7yoilsho	2787	2	obtained	obtain	VBN
cord-006229-7yoilsho	2787	3	mouse	mouse	NN
cord-006229-7yoilsho	2787	4	lines	line	NNS
cord-006229-7yoilsho	2787	5	show	show	VBP
cord-006229-7yoilsho	2787	6	different	different	JJ
cord-006229-7yoilsho	2787	7	expression	expression	NN
cord-006229-7yoilsho	2787	8	levels	level	NNS
cord-006229-7yoilsho	2787	9	but	but	CC
cord-006229-7yoilsho	2787	10	identical	identical	JJ
cord-006229-7yoilsho	2787	11	expression	expression	NN
cord-006229-7yoilsho	2787	12	patterns	pattern	NNS
cord-006229-7yoilsho	2787	13	with	with	IN
cord-006229-7yoilsho	2787	14	predominant	predominant	JJ
cord-006229-7yoilsho	2787	15	expression	expression	NN
cord-006229-7yoilsho	2787	16	in	in	IN
cord-006229-7yoilsho	2787	17	the	the	DT
cord-006229-7yoilsho	2787	18	cerebellum	cerebellum	NN
cord-006229-7yoilsho	2787	19	,	,	,
cord-006229-7yoilsho	2787	20	hippocampus	hippocampus	NN
cord-006229-7yoilsho	2787	21	,	,	,
cord-006229-7yoilsho	2787	22	and	and	CC
cord-006229-7yoilsho	2787	23	thalamus	thalamus	NN
cord-006229-7yoilsho	2787	24	.	.	.
cord-006229-7yoilsho	2788	1	Using	use	VBG
cord-006229-7yoilsho	2788	2	cell	cell	NN
cord-006229-7yoilsho	2788	3	type	type	NN
cord-006229-7yoilsho	2788	4	-	-	HYPH
cord-006229-7yoilsho	2788	5	specific	specific	JJ
cord-006229-7yoilsho	2788	6	markers	marker	NNS
cord-006229-7yoilsho	2788	7	,	,	,
cord-006229-7yoilsho	2788	8	P2X7-EGFP	P2X7-EGFP	NNP
cord-006229-7yoilsho	2788	9	was	be	VBD
cord-006229-7yoilsho	2788	10	identified	identify	VBN
cord-006229-7yoilsho	2788	11	in	in	IN
cord-006229-7yoilsho	2788	12	almost	almost	RB
cord-006229-7yoilsho	2788	13	all	all	DT
cord-006229-7yoilsho	2788	14	microglia	microglia	NNS
cord-006229-7yoilsho	2788	15	and	and	CC
cord-006229-7yoilsho	2788	16	subpopulations	subpopulation	NNS
cord-006229-7yoilsho	2788	17	of	of	IN
cord-006229-7yoilsho	2788	18	oligodendrocytes	oligodendrocyte	NNS
cord-006229-7yoilsho	2788	19	and	and	CC
cord-006229-7yoilsho	2788	20	astrocytes	astrocyte	NNS
cord-006229-7yoilsho	2788	21	in	in	IN
cord-006229-7yoilsho	2788	22	the	the	DT
cord-006229-7yoilsho	2788	23	brain	brain	NN
cord-006229-7yoilsho	2788	24	.	.	.
cord-006229-7yoilsho	2789	1	In	in	IN
cord-006229-7yoilsho	2789	2	the	the	DT
cord-006229-7yoilsho	2789	3	spinal	spinal	JJ
cord-006229-7yoilsho	2789	4	cord	cord	NN
cord-006229-7yoilsho	2789	5	,	,	,
cord-006229-7yoilsho	2789	6	numerous	numerous	JJ
cord-006229-7yoilsho	2789	7	astrocytes	astrocyte	NNS
cord-006229-7yoilsho	2789	8	in	in	IN
cord-006229-7yoilsho	2789	9	the	the	DT
cord-006229-7yoilsho	2789	10	white	white	JJ
cord-006229-7yoilsho	2789	11	matter	matter	NN
cord-006229-7yoilsho	2789	12	showed	show	VBD
cord-006229-7yoilsho	2789	13	EGFP	EGFP	NNP
cord-006229-7yoilsho	2789	14	immunoreactivity	immunoreactivity	NN
cord-006229-7yoilsho	2789	15	.	.	.
cord-006229-7yoilsho	2790	1	So	so	RB
cord-006229-7yoilsho	2790	2	far	far	RB
cord-006229-7yoilsho	2790	3	,	,	,
cord-006229-7yoilsho	2790	4	no	no	DT
cord-006229-7yoilsho	2790	5	EGFP	EGFP	NNP
cord-006229-7yoilsho	2790	6	immunostaining	immunostaining	NN
cord-006229-7yoilsho	2790	7	was	be	VBD
cord-006229-7yoilsho	2790	8	found	find	VBN
cord-006229-7yoilsho	2790	9	on	on	IN
cord-006229-7yoilsho	2790	10	MAP2-and	MAP2-and	NNP
cord-006229-7yoilsho	2790	11	NeuN	NeuN	NNP
cord-006229-7yoilsho	2790	12	-	-	HYPH
cord-006229-7yoilsho	2790	13	positive	positive	JJ
cord-006229-7yoilsho	2790	14	cells	cell	NNS
cord-006229-7yoilsho	2790	15	indicating	indicate	VBG
cord-006229-7yoilsho	2790	16	that	that	IN
cord-006229-7yoilsho	2790	17	under	under	IN
cord-006229-7yoilsho	2790	18	non	non	JJ
cord-006229-7yoilsho	2790	19	-	-	JJ
cord-006229-7yoilsho	2790	20	pathological	pathological	JJ
cord-006229-7yoilsho	2790	21	conditions	condition	NNS
cord-006229-7yoilsho	2790	22	,	,	,
cord-006229-7yoilsho	2790	23	the	the	DT
cord-006229-7yoilsho	2790	24	P2X7	P2X7	NNP
cord-006229-7yoilsho	2790	25	receptor	receptor	NN
cord-006229-7yoilsho	2790	26	is	be	VBZ
cord-006229-7yoilsho	2790	27	not	not	RB
cord-006229-7yoilsho	2790	28	expressed	express	VBN
cord-006229-7yoilsho	2790	29	in	in	IN
cord-006229-7yoilsho	2790	30	neurons	neuron	NNS
cord-006229-7yoilsho	2790	31	of	of	IN
cord-006229-7yoilsho	2790	32	the	the	DT
cord-006229-7yoilsho	2790	33	CNS	CNS	NNP
cord-006229-7yoilsho	2790	34	.	.	.
cord-006229-7yoilsho	2791	1	Interestingly	interestingly	RB
cord-006229-7yoilsho	2791	2	,	,	,
cord-006229-7yoilsho	2791	3	a	a	DT
cord-006229-7yoilsho	2791	4	higher	high	JJR
cord-006229-7yoilsho	2791	5	expression	expression	NN
cord-006229-7yoilsho	2791	6	level	level	NN
cord-006229-7yoilsho	2791	7	of	of	IN
cord-006229-7yoilsho	2791	8	CD68	cd68	NN
cord-006229-7yoilsho	2791	9	protein	protein	NN
cord-006229-7yoilsho	2791	10	was	be	VBD
cord-006229-7yoilsho	2791	11	observed	observe	VBN
cord-006229-7yoilsho	2791	12	in	in	IN
cord-006229-7yoilsho	2791	13	the	the	DT
cord-006229-7yoilsho	2791	14	P2X7R	P2X7R	NNP
cord-006229-7yoilsho	2791	15	-	-	HYPH
cord-006229-7yoilsho	2791	16	overexpressing	overexpresse	VBG
cord-006229-7yoilsho	2791	17	mice	mouse	NNS
cord-006229-7yoilsho	2791	18	.	.	.
cord-006229-7yoilsho	2792	1	These	these	DT
cord-006229-7yoilsho	2792	2	results	result	NNS
cord-006229-7yoilsho	2792	3	suggests	suggest	VBZ
cord-006229-7yoilsho	2792	4	that	that	IN
cord-006229-7yoilsho	2792	5	overexpression	overexpression	NN
cord-006229-7yoilsho	2792	6	of	of	IN
cord-006229-7yoilsho	2792	7	P2X7Rs	p2x7rs	NN
cord-006229-7yoilsho	2792	8	alone	alone	RB
cord-006229-7yoilsho	2792	9	is	be	VBZ
cord-006229-7yoilsho	2792	10	sufficient	sufficient	JJ
cord-006229-7yoilsho	2792	11	to	to	TO
cord-006229-7yoilsho	2792	12	induce	induce	VB
cord-006229-7yoilsho	2792	13	microglia	microglia	JJ
cord-006229-7yoilsho	2792	14	activation	activation	NN
cord-006229-7yoilsho	2792	15	,	,	,
cord-006229-7yoilsho	2792	16	even	even	RB
cord-006229-7yoilsho	2792	17	under	under	IN
cord-006229-7yoilsho	2792	18	non	non	JJ
cord-006229-7yoilsho	2792	19	-	-	JJ
cord-006229-7yoilsho	2792	20	pathological	pathological	JJ
cord-006229-7yoilsho	2792	21	conditions	condition	NNS
cord-006229-7yoilsho	2792	22	.	.	.
cord-006229-7yoilsho	2793	1	Since	since	IN
cord-006229-7yoilsho	2793	2	CD68	CD68	NNP
cord-006229-7yoilsho	2793	3	primarily	primarily	RB
cord-006229-7yoilsho	2793	4	localizes	localize	VBZ
cord-006229-7yoilsho	2793	5	to	to	IN
cord-006229-7yoilsho	2793	6	lysosomes	lysosome	NNS
cord-006229-7yoilsho	2793	7	and	and	CC
cord-006229-7yoilsho	2793	8	endosomes	endosome	NNS
cord-006229-7yoilsho	2793	9	,	,	,
cord-006229-7yoilsho	2793	10	this	this	DT
cord-006229-7yoilsho	2793	11	further	further	RB
cord-006229-7yoilsho	2793	12	supports	support	VBZ
cord-006229-7yoilsho	2793	13	a	a	DT
cord-006229-7yoilsho	2793	14	role	role	NN
cord-006229-7yoilsho	2793	15	of	of	IN
cord-006229-7yoilsho	2793	16	the	the	DT
cord-006229-7yoilsho	2793	17	P2X7R	P2X7R	NNP
cord-006229-7yoilsho	2793	18	in	in	IN
cord-006229-7yoilsho	2793	19	the	the	DT
cord-006229-7yoilsho	2793	20	regulation	regulation	NN
cord-006229-7yoilsho	2793	21	of	of	IN
cord-006229-7yoilsho	2793	22	phagocytosis	phagocytosis	NN
cord-006229-7yoilsho	2793	23	.	.	.
cord-006229-7yoilsho	2794	1	To	to	TO
cord-006229-7yoilsho	2794	2	validate	validate	VB
cord-006229-7yoilsho	2794	3	these	these	DT
cord-006229-7yoilsho	2794	4	data	datum	NNS
cord-006229-7yoilsho	2794	5	,	,	,
cord-006229-7yoilsho	2794	6	conditional	conditional	JJ
cord-006229-7yoilsho	2794	7	knockout	knockout	NN
cord-006229-7yoilsho	2794	8	mice	mouse	NNS
cord-006229-7yoilsho	2794	9	are	be	VBP
cord-006229-7yoilsho	2794	10	generated	generate	VBN
cord-006229-7yoilsho	2794	11	.	.	.
cord-006229-7yoilsho	2795	1	The	the	DT
cord-006229-7yoilsho	2795	2	current	current	JJ
cord-006229-7yoilsho	2795	3	status	status	NN
cord-006229-7yoilsho	2795	4	of	of	IN
cord-006229-7yoilsho	2795	5	the	the	DT
cord-006229-7yoilsho	2795	6	project	project	NN
cord-006229-7yoilsho	2795	7	will	will	MD
cord-006229-7yoilsho	2795	8	be	be	VB
cord-006229-7yoilsho	2795	9	presented	present	VBN
cord-006229-7yoilsho	2795	10	.	.	.
cord-006229-7yoilsho	2796	1	The	the	DT
cord-006229-7yoilsho	2796	2	Two	two	CD
cord-006229-7yoilsho	2796	3	-	-	HYPH
cord-006229-7yoilsho	2796	4	Pore	pore	NN
cord-006229-7yoilsho	2796	5	Channels	Channels	NNP
cord-006229-7yoilsho	2796	6	(	(	-LRB-
cord-006229-7yoilsho	2796	7	TPCs	tpc	NNS
cord-006229-7yoilsho	2796	8	)	)	-RRB-
cord-006229-7yoilsho	2796	9	-TPC1	-TPC1	NNP
cord-006229-7yoilsho	2797	1	and	and	CC
cord-006229-7yoilsho	2797	2	TPC2	TPC2	NNP
cord-006229-7yoilsho	2797	3	-are	-are	:
cord-006229-7yoilsho	2797	4	located	locate	VBN
cord-006229-7yoilsho	2797	5	in	in	IN
cord-006229-7yoilsho	2797	6	membranes	membrane	NNS
cord-006229-7yoilsho	2797	7	of	of	IN
cord-006229-7yoilsho	2797	8	intracellular	intracellular	JJ
cord-006229-7yoilsho	2797	9	organelles	organelle	NNS
cord-006229-7yoilsho	2797	10	of	of	IN
cord-006229-7yoilsho	2797	11	the	the	DT
cord-006229-7yoilsho	2797	12	endo	endo	NN
cord-006229-7yoilsho	2797	13	-	-	HYPH
cord-006229-7yoilsho	2797	14	lysosomal	lysosomal	JJ
cord-006229-7yoilsho	2797	15	system	system	NN
cord-006229-7yoilsho	2797	16	.	.	.
cord-006229-7yoilsho	2798	1	The	the	DT
cord-006229-7yoilsho	2798	2	TPC	tpc	NN
cord-006229-7yoilsho	2798	3	-	-	HYPH
cord-006229-7yoilsho	2798	4	protein	protein	NN
cord-006229-7yoilsho	2798	5	-	-	HYPH
cord-006229-7yoilsho	2798	6	monomer	monomer	NN
cord-006229-7yoilsho	2798	7	contains	contain	VBZ
cord-006229-7yoilsho	2798	8	two	two	CD
cord-006229-7yoilsho	2798	9	homologous	homologous	JJ
cord-006229-7yoilsho	2798	10	domains	domain	NNS
cord-006229-7yoilsho	2798	11	with	with	IN
cord-006229-7yoilsho	2798	12	six	six	CD
cord-006229-7yoilsho	2798	13	transmembrane	transmembrane	NN
cord-006229-7yoilsho	2798	14	α	α	NNS
cord-006229-7yoilsho	2798	15	-	-	:
cord-006229-7yoilsho	2798	16	helices	helix	NNS
cord-006229-7yoilsho	2798	17	each	each	DT
cord-006229-7yoilsho	2798	18	.	.	.
cord-006229-7yoilsho	2799	1	A	a	DT
cord-006229-7yoilsho	2799	2	functional	functional	JJ
cord-006229-7yoilsho	2799	3	TPC	tpc	NN
cord-006229-7yoilsho	2799	4	probably	probably	RB
cord-006229-7yoilsho	2799	5	consists	consist	VBZ
cord-006229-7yoilsho	2799	6	of	of	IN
cord-006229-7yoilsho	2799	7	a	a	DT
cord-006229-7yoilsho	2799	8	dimer	dimer	NN
cord-006229-7yoilsho	2799	9	of	of	IN
cord-006229-7yoilsho	2799	10	two	two	CD
cord-006229-7yoilsho	2799	11	TPC	TPC	NNP
cord-006229-7yoilsho	2799	12	-	-	HYPH
cord-006229-7yoilsho	2799	13	proteins	protein	NNS
cord-006229-7yoilsho	2799	14	resembling	resemble	VBG
cord-006229-7yoilsho	2799	15	an	an	DT
cord-006229-7yoilsho	2799	16	ion	ion	NN
cord-006229-7yoilsho	2799	17	channel	channel	NN
cord-006229-7yoilsho	2799	18	architecture	architecture	NN
cord-006229-7yoilsho	2799	19	with	with	IN
cord-006229-7yoilsho	2799	20	the	the	DT
cord-006229-7yoilsho	2799	21	typical	typical	JJ
cord-006229-7yoilsho	2799	22	four	four	CD
cord-006229-7yoilsho	2799	23	domain	domain	NN
cord-006229-7yoilsho	2799	24	organization	organization	NN
cord-006229-7yoilsho	2799	25	like	like	IN
cord-006229-7yoilsho	2799	26	voltage	voltage	VB
cord-006229-7yoilsho	2799	27	gated	gate	VBN
cord-006229-7yoilsho	2799	28	Na	Na	NNP
cord-006229-7yoilsho	2799	29	+	+	CC
cord-006229-7yoilsho	2800	1	or	or	CC
cord-006229-7yoilsho	2800	2	Ca	Ca	NNP
cord-006229-7yoilsho	2800	3	2	2	CD
cord-006229-7yoilsho	2801	1	+	+	CC
cord-006229-7yoilsho	2801	2	channels	channel	NNS
cord-006229-7yoilsho	2801	3	or	or	CC
cord-006229-7yoilsho	2801	4	such	such	JJ
cord-006229-7yoilsho	2801	5	as	as	IN
cord-006229-7yoilsho	2801	6	TRP	TRP	NNP
cord-006229-7yoilsho	2801	7	channels	channel	NNS
cord-006229-7yoilsho	2801	8	.	.	.
cord-006229-7yoilsho	2802	1	Due	due	IN
cord-006229-7yoilsho	2802	2	to	to	IN
cord-006229-7yoilsho	2802	3	their	-PRON-	PRP$
cord-006229-7yoilsho	2802	4	biophysical	biophysical	JJ
cord-006229-7yoilsho	2802	5	properties	property	NNS
cord-006229-7yoilsho	2802	6	,	,	,
cord-006229-7yoilsho	2802	7	TPC1	TPC1	NNP
cord-006229-7yoilsho	2802	8	and	and	CC
cord-006229-7yoilsho	2802	9	TPC2	TPC2	NNP
cord-006229-7yoilsho	2802	10	are	be	VBP
cord-006229-7yoilsho	2802	11	assumed	assume	VBN
cord-006229-7yoilsho	2802	12	to	to	TO
cord-006229-7yoilsho	2802	13	be	be	VB
cord-006229-7yoilsho	2802	14	involved	involve	VBN
cord-006229-7yoilsho	2802	15	in	in	IN
cord-006229-7yoilsho	2802	16	the	the	DT
cord-006229-7yoilsho	2802	17	efflux	efflux	NN
cord-006229-7yoilsho	2802	18	of	of	IN
cord-006229-7yoilsho	2802	19	Ca	Ca	NNP
cord-006229-7yoilsho	2802	20	2	2	CD
cord-006229-7yoilsho	2802	21	+	+	CC
cord-006229-7yoilsho	2802	22	from	from	IN
cord-006229-7yoilsho	2802	23	intracellular	intracellular	JJ
cord-006229-7yoilsho	2802	24	organelles	organelle	NNS
cord-006229-7yoilsho	2802	25	and	and	CC
cord-006229-7yoilsho	2802	26	thereby	thereby	RB
cord-006229-7yoilsho	2802	27	contribute	contribute	VB
cord-006229-7yoilsho	2802	28	to	to	IN
cord-006229-7yoilsho	2802	29	fusion	fusion	NN
cord-006229-7yoilsho	2802	30	/	/	SYM
cord-006229-7yoilsho	2802	31	fission	fission	NN
cord-006229-7yoilsho	2802	32	processes	process	NNS
cord-006229-7yoilsho	2802	33	of	of	IN
cord-006229-7yoilsho	2802	34	endosomes	endosome	NNS
cord-006229-7yoilsho	2802	35	and	and	CC
cord-006229-7yoilsho	2802	36	lysosomes	lysosome	NNS
cord-006229-7yoilsho	2802	37	.	.	.
cord-006229-7yoilsho	2803	1	Thus	thus	RB
cord-006229-7yoilsho	2803	2	,	,	,
cord-006229-7yoilsho	2803	3	TPCs	tpc	NNS
cord-006229-7yoilsho	2803	4	are	be	VBP
cord-006229-7yoilsho	2803	5	supposed	suppose	VBN
cord-006229-7yoilsho	2803	6	to	to	TO
cord-006229-7yoilsho	2803	7	be	be	VB
cord-006229-7yoilsho	2803	8	important	important	JJ
cord-006229-7yoilsho	2803	9	regulators	regulator	NNS
cord-006229-7yoilsho	2803	10	for	for	IN
cord-006229-7yoilsho	2803	11	vesicle	vesicle	NN
cord-006229-7yoilsho	2803	12	trafficking	trafficking	NN
cord-006229-7yoilsho	2803	13	,	,	,
cord-006229-7yoilsho	2803	14	sorting	sorting	NN
cord-006229-7yoilsho	2803	15	and	and	CC
cord-006229-7yoilsho	2803	16	degradation	degradation	NN
cord-006229-7yoilsho	2803	17	/	/	SYM
cord-006229-7yoilsho	2803	18	recycling	recycling	NN
cord-006229-7yoilsho	2803	19	processes	process	NNS
cord-006229-7yoilsho	2803	20	.	.	.
cord-006229-7yoilsho	2804	1	Recently	recently	RB
cord-006229-7yoilsho	2804	2	,	,	,
cord-006229-7yoilsho	2804	3	it	-PRON-	PRP
cord-006229-7yoilsho	2804	4	was	be	VBD
cord-006229-7yoilsho	2804	5	shown	show	VBN
cord-006229-7yoilsho	2804	6	that	that	IN
cord-006229-7yoilsho	2804	7	virus	virus	NN
cord-006229-7yoilsho	2804	8	entry	entry	NN
cord-006229-7yoilsho	2804	9	and	and	CC
cord-006229-7yoilsho	2804	10	replication	replication	NN
cord-006229-7yoilsho	2804	11	of	of	IN
cord-006229-7yoilsho	2804	12	certain	certain	JJ
cord-006229-7yoilsho	2804	13	strains	strain	NNS
cord-006229-7yoilsho	2804	14	of	of	IN
cord-006229-7yoilsho	2804	15	Filoviridae	Filoviridae	NNP
cord-006229-7yoilsho	2804	16	-such	-such	CD
cord-006229-7yoilsho	2804	17	as	as	IN
cord-006229-7yoilsho	2804	18	Ebola	Ebola	NNP
cord-006229-7yoilsho	2804	19	-depends	-depend	VBZ
cord-006229-7yoilsho	2804	20	on	on	IN
cord-006229-7yoilsho	2804	21	functional	functional	JJ
cord-006229-7yoilsho	2804	22	TPCs	tpc	NNS
cord-006229-7yoilsho	2804	23	and	and	CC
cord-006229-7yoilsho	2804	24	that	that	IN
cord-006229-7yoilsho	2804	25	either	either	DT
cord-006229-7yoilsho	2804	26	block	block	NN
cord-006229-7yoilsho	2804	27	or	or	CC
cord-006229-7yoilsho	2804	28	genetic	genetic	JJ
cord-006229-7yoilsho	2804	29	inactivation	inactivation	NN
cord-006229-7yoilsho	2804	30	of	of	IN
cord-006229-7yoilsho	2804	31	TPCs	tpc	NNS
cord-006229-7yoilsho	2804	32	reduces	reduce	VBZ
cord-006229-7yoilsho	2804	33	virus	virus	NN
cord-006229-7yoilsho	2804	34	infectivity	infectivity	NN
cord-006229-7yoilsho	2804	35	.	.	.
cord-006229-7yoilsho	2805	1	A	a	DT
cord-006229-7yoilsho	2805	2	large	large	JJ
cord-006229-7yoilsho	2805	3	family	family	NN
cord-006229-7yoilsho	2805	4	of	of	IN
cord-006229-7yoilsho	2805	5	bacterial	bacterial	JJ
cord-006229-7yoilsho	2805	6	protein	protein	NN
cord-006229-7yoilsho	2805	7	toxins	toxin	NNS
cord-006229-7yoilsho	2805	8	elicit	elicit	VBP
cord-006229-7yoilsho	2805	9	their	-PRON-	PRP$
cord-006229-7yoilsho	2805	10	effects	effect	NNS
cord-006229-7yoilsho	2805	11	by	by	IN
cord-006229-7yoilsho	2805	12	modification	modification	NN
cord-006229-7yoilsho	2805	13	of	of	IN
cord-006229-7yoilsho	2805	14	intracellular	intracellular	JJ
cord-006229-7yoilsho	2805	15	target	target	NN
cord-006229-7yoilsho	2805	16	proteins	protein	NNS
cord-006229-7yoilsho	2805	17	of	of	IN
cord-006229-7yoilsho	2805	18	host	host	NN
cord-006229-7yoilsho	2805	19	cells	cell	NNS
cord-006229-7yoilsho	2805	20	.	.	.
cord-006229-7yoilsho	2806	1	These	these	DT
cord-006229-7yoilsho	2806	2	toxins	toxin	NNS
cord-006229-7yoilsho	2806	3	are	be	VBP
cord-006229-7yoilsho	2806	4	taken	take	VBN
cord-006229-7yoilsho	2806	5	up	up	RP
cord-006229-7yoilsho	2806	6	by	by	IN
cord-006229-7yoilsho	2806	7	receptor	receptor	NN
cord-006229-7yoilsho	2806	8	mediated	mediate	VBN
cord-006229-7yoilsho	2806	9	endocytosis	endocytosis	NN
cord-006229-7yoilsho	2806	10	and	and	CC
cord-006229-7yoilsho	2806	11	follow	follow	VB
cord-006229-7yoilsho	2806	12	different	different	JJ
cord-006229-7yoilsho	2806	13	endosomal	endosomal	NNP
cord-006229-7yoilsho	2806	14	routes	route	NNS
cord-006229-7yoilsho	2806	15	to	to	TO
cord-006229-7yoilsho	2806	16	reach	reach	VB
cord-006229-7yoilsho	2806	17	their	-PRON-	PRP$
cord-006229-7yoilsho	2806	18	final	final	JJ
cord-006229-7yoilsho	2806	19	cytosolic	cytosolic	JJ
cord-006229-7yoilsho	2806	20	destination	destination	NN
cord-006229-7yoilsho	2806	21	.	.	.
cord-006229-7yoilsho	2807	1	These	these	DT
cord-006229-7yoilsho	2807	2	toxins	toxin	NNS
cord-006229-7yoilsho	2807	3	principally	principally	RB
cord-006229-7yoilsho	2807	4	use	use	VBP
cord-006229-7yoilsho	2807	5	two	two	CD
cord-006229-7yoilsho	2807	6	different	different	JJ
cord-006229-7yoilsho	2807	7	intracellular	intracellular	JJ
cord-006229-7yoilsho	2807	8	routes	route	NNS
cord-006229-7yoilsho	2807	9	:	:	:
cord-006229-7yoilsho	2807	10	The	the	DT
cord-006229-7yoilsho	2807	11	first	first	JJ
cord-006229-7yoilsho	2807	12	group	group	NN
cord-006229-7yoilsho	2807	13	uses	use	VBZ
cord-006229-7yoilsho	2807	14	an	an	DT
cord-006229-7yoilsho	2807	15	entry	entry	NN
cord-006229-7yoilsho	2807	16	route	route	NN
cord-006229-7yoilsho	2807	17	via	via	IN
cord-006229-7yoilsho	2807	18	early	early	JJ
cord-006229-7yoilsho	2807	19	or	or	CC
cord-006229-7yoilsho	2807	20	late	late	JJ
cord-006229-7yoilsho	2807	21	endosomes	endosome	NNS
cord-006229-7yoilsho	2807	22	(	(	-LRB-
cord-006229-7yoilsho	2807	23	short	short	JJ
cord-006229-7yoilsho	2807	24	-	-	HYPH
cord-006229-7yoilsho	2807	25	trip	trip	NN
cord-006229-7yoilsho	2807	26	toxins	toxin	NNS
cord-006229-7yoilsho	2807	27	)	)	-RRB-
cord-006229-7yoilsho	2807	28	,	,	,
cord-006229-7yoilsho	2807	29	the	the	DT
cord-006229-7yoilsho	2807	30	second	second	JJ
cord-006229-7yoilsho	2807	31	group	group	NN
cord-006229-7yoilsho	2807	32	takes	take	VBZ
cord-006229-7yoilsho	2807	33	a	a	DT
cord-006229-7yoilsho	2807	34	retrograde	retrograde	JJ
cord-006229-7yoilsho	2807	35	route	route	NN
cord-006229-7yoilsho	2807	36	via	via	IN
cord-006229-7yoilsho	2807	37	endosomes	endosome	NNS
cord-006229-7yoilsho	2807	38	,	,	,
cord-006229-7yoilsho	2807	39	Golgi	Golgi	NNP
cord-006229-7yoilsho	2807	40	network	network	NN
cord-006229-7yoilsho	2807	41	and	and	CC
cord-006229-7yoilsho	2807	42	the	the	DT
cord-006229-7yoilsho	2807	43	endoplasmic	endoplasmic	NN
cord-006229-7yoilsho	2807	44	reticulum	reticulum	NN
cord-006229-7yoilsho	2807	45	(	(	-LRB-
cord-006229-7yoilsho	2807	46	long	long	JJ
cord-006229-7yoilsho	2807	47	-	-	HYPH
cord-006229-7yoilsho	2807	48	trip	trip	NN
cord-006229-7yoilsho	2807	49	toxins	toxin	NNS
cord-006229-7yoilsho	2807	50	)	)	-RRB-
cord-006229-7yoilsho	2807	51	to	to	TO
cord-006229-7yoilsho	2807	52	get	get	VB
cord-006229-7yoilsho	2807	53	access	access	NN
cord-006229-7yoilsho	2807	54	to	to	IN
cord-006229-7yoilsho	2807	55	the	the	DT
cord-006229-7yoilsho	2807	56	cytosol	cytosol	NN
cord-006229-7yoilsho	2807	57	.	.	.
cord-006229-7yoilsho	2808	1	Translocation	translocation	NN
cord-006229-7yoilsho	2808	2	of	of	IN
cord-006229-7yoilsho	2808	3	short	short	JJ
cord-006229-7yoilsho	2808	4	-	-	HYPH
cord-006229-7yoilsho	2808	5	trip	trip	NN
cord-006229-7yoilsho	2808	6	toxins	toxin	NNS
cord-006229-7yoilsho	2808	7	-such	-such	.
cord-006229-7yoilsho	2809	1	as	as	IN
cord-006229-7yoilsho	2809	2	Diphtheria	Diphtheria	NNP
cord-006229-7yoilsho	2809	3	toxin	toxin	NN
cord-006229-7yoilsho	2809	4	(	(	-LRB-
cord-006229-7yoilsho	2809	5	DT	DT	NNP
cord-006229-7yoilsho	2809	6	)	)	-RRB-
cord-006229-7yoilsho	2809	7	,	,	,
cord-006229-7yoilsho	2809	8	Pasteurella	Pasteurella	NNP
cord-006229-7yoilsho	2809	9	multocida	multocida	NN
cord-006229-7yoilsho	2809	10	toxin	toxin	NN
cord-006229-7yoilsho	2809	11	(	(	-LRB-
cord-006229-7yoilsho	2809	12	PMT	PMT	NNP
cord-006229-7yoilsho	2809	13	)	)	-RRB-
cord-006229-7yoilsho	2809	14	and	and	CC
cord-006229-7yoilsho	2809	15	Bacillus	Bacillus	NNP
cord-006229-7yoilsho	2809	16	anthracis	anthracis	NN
cord-006229-7yoilsho	2809	17	lethal	lethal	JJ
cord-006229-7yoilsho	2809	18	factor	factor	NN
cord-006229-7yoilsho	2809	19	(	(	-LRB-
cord-006229-7yoilsho	2809	20	PA	PA	NNP
cord-006229-7yoilsho	2809	21	/	/	SYM
cord-006229-7yoilsho	2809	22	LF	LF	NNP
cord-006229-7yoilsho	2809	23	)	)	-RRB-
cord-006229-7yoilsho	2810	1	-from	-from	JJ
cord-006229-7yoilsho	2810	2	early	early	JJ
cord-006229-7yoilsho	2810	3	and	and	CC
cord-006229-7yoilsho	2810	4	late	late	JJ
cord-006229-7yoilsho	2810	5	endosomes	endosome	NNS
cord-006229-7yoilsho	2810	6	into	into	IN
cord-006229-7yoilsho	2810	7	the	the	DT
cord-006229-7yoilsho	2810	8	cytosol	cytosol	NN
cord-006229-7yoilsho	2810	9	is	be	VBZ
cord-006229-7yoilsho	2810	10	driven	drive	VBN
cord-006229-7yoilsho	2810	11	by	by	IN
cord-006229-7yoilsho	2810	12	ongoing	ongoing	JJ
cord-006229-7yoilsho	2810	13	acidification	acidification	NN
cord-006229-7yoilsho	2810	14	.	.	.
cord-006229-7yoilsho	2811	1	Long	long	JJ
cord-006229-7yoilsho	2811	2	-	-	HYPH
cord-006229-7yoilsho	2811	3	trip	trip	NN
cord-006229-7yoilsho	2811	4	toxins	toxin	NNS
cord-006229-7yoilsho	2812	1	-including	-include	VBG
cord-006229-7yoilsho	2812	2	Cholera	cholera	NN
cord-006229-7yoilsho	2812	3	toxin	toxin	NN
cord-006229-7yoilsho	2812	4	(	(	-LRB-
cord-006229-7yoilsho	2812	5	CT	CT	NNP
cord-006229-7yoilsho	2812	6	)	)	-RRB-
cord-006229-7yoilsho	2812	7	-are	-are	:
cord-006229-7yoilsho	2813	1	retrogradely	retrogradely	RB
cord-006229-7yoilsho	2813	2	transported	transport	VBN
cord-006229-7yoilsho	2813	3	after	after	IN
cord-006229-7yoilsho	2813	4	endocytosis	endocytosis	NN
cord-006229-7yoilsho	2813	5	via	via	IN
cord-006229-7yoilsho	2813	6	the	the	DT
cord-006229-7yoilsho	2813	7	Golgi	Golgi	NNP
cord-006229-7yoilsho	2813	8	apparatus	apparatus	NN
cord-006229-7yoilsho	2813	9	to	to	IN
cord-006229-7yoilsho	2813	10	the	the	DT
cord-006229-7yoilsho	2813	11	endoplasmic	endoplasmic	NN
cord-006229-7yoilsho	2813	12	reticulum	reticulum	NN
cord-006229-7yoilsho	2813	13	(	(	-LRB-
cord-006229-7yoilsho	2813	14	ER	ER	NNP
cord-006229-7yoilsho	2813	15	)	)	-RRB-
cord-006229-7yoilsho	2813	16	.	.	.
cord-006229-7yoilsho	2814	1	Within	within	IN
cord-006229-7yoilsho	2814	2	the	the	DT
cord-006229-7yoilsho	2814	3	ER	ER	NNP
cord-006229-7yoilsho	2814	4	a	a	DT
cord-006229-7yoilsho	2814	5	specific	specific	JJ
cord-006229-7yoilsho	2814	6	peptide	peptide	NN
cord-006229-7yoilsho	2814	7	-	-	HYPH
cord-006229-7yoilsho	2814	8	motif	motif	NN
cord-006229-7yoilsho	2814	9	allows	allow	VBZ
cord-006229-7yoilsho	2814	10	the	the	DT
cord-006229-7yoilsho	2814	11	translocation	translocation	NN
cord-006229-7yoilsho	2814	12	into	into	IN
cord-006229-7yoilsho	2814	13	the	the	DT
cord-006229-7yoilsho	2814	14	cytosol	cytosol	NN
cord-006229-7yoilsho	2814	15	.	.	.
cord-006229-7yoilsho	2815	1	Due	due	IN
cord-006229-7yoilsho	2815	2	to	to	IN
cord-006229-7yoilsho	2815	3	the	the	DT
cord-006229-7yoilsho	2815	4	role	role	NN
cord-006229-7yoilsho	2815	5	of	of	IN
cord-006229-7yoilsho	2815	6	TPC1	TPC1	NNP
cord-006229-7yoilsho	2815	7	for	for	IN
cord-006229-7yoilsho	2815	8	vesicle	vesicle	NN
cord-006229-7yoilsho	2815	9	fusion	fusion	NN
cord-006229-7yoilsho	2815	10	&	&	CC
cord-006229-7yoilsho	2815	11	fission	fission	NN
cord-006229-7yoilsho	2815	12	processes	process	NNS
cord-006229-7yoilsho	2815	13	we	-PRON-	PRP
cord-006229-7yoilsho	2815	14	investigated	investigate	VBD
cord-006229-7yoilsho	2815	15	a	a	DT
cord-006229-7yoilsho	2815	16	potential	potential	JJ
cord-006229-7yoilsho	2815	17	impact	impact	NN
cord-006229-7yoilsho	2815	18	of	of	IN
cord-006229-7yoilsho	2815	19	TPC1	TPC1	NNP
cord-006229-7yoilsho	2815	20	on	on	IN
cord-006229-7yoilsho	2815	21	the	the	DT
cord-006229-7yoilsho	2815	22	uptake	uptake	NN
cord-006229-7yoilsho	2815	23	of	of	IN
cord-006229-7yoilsho	2815	24	bacterial	bacterial	JJ
cord-006229-7yoilsho	2815	25	toxins	toxin	NNS
cord-006229-7yoilsho	2815	26	.	.	.
cord-006229-7yoilsho	2816	1	First	first	RB
cord-006229-7yoilsho	2816	2	we	-PRON-	PRP
cord-006229-7yoilsho	2816	3	determined	determine	VBD
cord-006229-7yoilsho	2816	4	the	the	DT
cord-006229-7yoilsho	2816	5	precise	precise	JJ
cord-006229-7yoilsho	2816	6	localization	localization	NN
cord-006229-7yoilsho	2816	7	of	of	IN
cord-006229-7yoilsho	2816	8	TPC1	TPC1	NNP
cord-006229-7yoilsho	2816	9	in	in	IN
cord-006229-7yoilsho	2816	10	intracellular	intracellular	JJ
cord-006229-7yoilsho	2816	11	compartments	compartment	NNS
cord-006229-7yoilsho	2816	12	.	.	.
cord-006229-7yoilsho	2817	1	To	to	TO
cord-006229-7yoilsho	2817	2	deduce	deduce	VB
cord-006229-7yoilsho	2817	3	its	-PRON-	PRP$
cord-006229-7yoilsho	2817	4	role	role	NN
cord-006229-7yoilsho	2817	5	for	for	IN
cord-006229-7yoilsho	2817	6	trafficking	traffic	VBG
cord-006229-7yoilsho	2817	7	processes	process	NNS
cord-006229-7yoilsho	2817	8	we	-PRON-	PRP
cord-006229-7yoilsho	2817	9	performed	perform	VBD
cord-006229-7yoilsho	2817	10	co	co	NN
cord-006229-7yoilsho	2817	11	-	-	NN
cord-006229-7yoilsho	2817	12	localization	localization	NN
cord-006229-7yoilsho	2817	13	and	and	CC
cord-006229-7yoilsho	2817	14	correlation	correlation	NN
cord-006229-7yoilsho	2817	15	studies	study	NNS
cord-006229-7yoilsho	2817	16	with	with	IN
cord-006229-7yoilsho	2817	17	a	a	DT
cord-006229-7yoilsho	2817	18	whole	whole	JJ
cord-006229-7yoilsho	2817	19	set	set	NN
cord-006229-7yoilsho	2817	20	of	of	IN
cord-006229-7yoilsho	2817	21	established	establish	VBN
cord-006229-7yoilsho	2817	22	markers	marker	NNS
cord-006229-7yoilsho	2817	23	such	such	JJ
cord-006229-7yoilsho	2817	24	as	as	IN
cord-006229-7yoilsho	2817	25	Rab	Rab	NNP
cord-006229-7yoilsho	2817	26	-	-	HYPH
cord-006229-7yoilsho	2817	27	GTPases	gtpase	NNS
cord-006229-7yoilsho	2817	28	and	and	CC
cord-006229-7yoilsho	2817	29	PIPs	pip	NNS
cord-006229-7yoilsho	2817	30	.	.	.
cord-006229-7yoilsho	2818	1	Second	second	RB
cord-006229-7yoilsho	2818	2	we	-PRON-	PRP
cord-006229-7yoilsho	2818	3	intoxicated	intoxicate	VBD
cord-006229-7yoilsho	2818	4	wild	wild	JJ
cord-006229-7yoilsho	2818	5	-	-	HYPH
cord-006229-7yoilsho	2818	6	type	type	NN
cord-006229-7yoilsho	2818	7	and	and	CC
cord-006229-7yoilsho	2818	8	TPC1	TPC1	NNP
cord-006229-7yoilsho	2818	9	deficient	deficient	JJ
cord-006229-7yoilsho	2818	10	cell	cell	NN
cord-006229-7yoilsho	2818	11	lines	line	NNS
cord-006229-7yoilsho	2818	12	with	with	IN
cord-006229-7yoilsho	2818	13	different	different	JJ
cord-006229-7yoilsho	2818	14	bacterial	bacterial	JJ
cord-006229-7yoilsho	2818	15	protein	protein	NN
cord-006229-7yoilsho	2818	16	toxins	toxin	NNS
cord-006229-7yoilsho	2818	17	such	such	JJ
cord-006229-7yoilsho	2818	18	as	as	IN
cord-006229-7yoilsho	2818	19	Cholera	Cholera	NNP
cord-006229-7yoilsho	2818	20	(	(	-LRB-
cord-006229-7yoilsho	2818	21	CT	CT	NNP
cord-006229-7yoilsho	2818	22	)	)	-RRB-
cord-006229-7yoilsho	2818	23	,	,	,
cord-006229-7yoilsho	2818	24	Diphtheria	Diphtheria	NNP
cord-006229-7yoilsho	2818	25	(	(	-LRB-
cord-006229-7yoilsho	2818	26	DT	DT	NNP
cord-006229-7yoilsho	2818	27	)	)	-RRB-
cord-006229-7yoilsho	2818	28	or	or	CC
cord-006229-7yoilsho	2818	29	Pasteurella	Pasteurella	NNP
cord-006229-7yoilsho	2818	30	multocida	multocida	NNP
cord-006229-7yoilsho	2818	31	(	(	-LRB-
cord-006229-7yoilsho	2818	32	PMT	PMT	NNP
cord-006229-7yoilsho	2818	33	)	)	-RRB-
cord-006229-7yoilsho	2818	34	toxin	toxin	NN
cord-006229-7yoilsho	2818	35	.	.	.
cord-006229-7yoilsho	2819	1	Using	use	VBG
cord-006229-7yoilsho	2819	2	cell	cell	NN
cord-006229-7yoilsho	2819	3	viability	viability	NN
cord-006229-7yoilsho	2819	4	and	and	CC
cord-006229-7yoilsho	2820	1	other	other	JJ
cord-006229-7yoilsho	2820	2	intoxication	intoxication	NN
cord-006229-7yoilsho	2820	3	assays	assay	NNS
cord-006229-7yoilsho	2821	1	we	-PRON-	PRP
cord-006229-7yoilsho	2821	2	investigated	investigate	VBD
cord-006229-7yoilsho	2821	3	the	the	DT
cord-006229-7yoilsho	2821	4	consequences	consequence	NNS
cord-006229-7yoilsho	2821	5	of	of	IN
cord-006229-7yoilsho	2821	6	TPC1-deletion	tpc1-deletion	NN
cord-006229-7yoilsho	2821	7	on	on	IN
cord-006229-7yoilsho	2821	8	bacterial	bacterial	JJ
cord-006229-7yoilsho	2821	9	toxin	toxin	NN
cord-006229-7yoilsho	2821	10	uptake	uptake	NN
cord-006229-7yoilsho	2821	11	,	,	,
cord-006229-7yoilsho	2821	12	translocation	translocation	NN
cord-006229-7yoilsho	2821	13	and	and	CC
cord-006229-7yoilsho	2821	14	cytotoxicity	cytotoxicity	NN
cord-006229-7yoilsho	2821	15	.	.	.
cord-006229-7yoilsho	2822	1	Universität	Universität	NNP
cord-006229-7yoilsho	2822	2	des	des	NNP
cord-006229-7yoilsho	2822	3	Saarlandes	Saarlandes	NNP
cord-006229-7yoilsho	2822	4	,	,	,
cord-006229-7yoilsho	2822	5	Institut	Institut	NNP
cord-006229-7yoilsho	2822	6	für	für	IN
cord-006229-7yoilsho	2822	7	Experimentelle	Experimentelle	NNP
cord-006229-7yoilsho	2823	1	und	und	IN
cord-006229-7yoilsho	2823	2	Klinische	Klinische	NNP
cord-006229-7yoilsho	2823	3	Pharmakologie	Pharmakologie	NNP
cord-006229-7yoilsho	2824	1	und	und	NNP
cord-006229-7yoilsho	2825	1	Toxikologie	Toxikologie	NNP
cord-006229-7yoilsho	2825	2	,	,	,
cord-006229-7yoilsho	2825	3	Homburg	Homburg	NNP
cord-006229-7yoilsho	2825	4	/	/	SYM
cord-006229-7yoilsho	2825	5	Saar	Saar	NNP
cord-006229-7yoilsho	2825	6	,	,	,
cord-006229-7yoilsho	2825	7	Germany	Germany	NNP
cord-006229-7yoilsho	2825	8	TRPM3	TRPM3	NNS
cord-006229-7yoilsho	2825	9	ion	ion	NN
cord-006229-7yoilsho	2825	10	channels	channel	NNS
cord-006229-7yoilsho	2825	11	are	be	VBP
cord-006229-7yoilsho	2825	12	considered	consider	VBN
cord-006229-7yoilsho	2825	13	to	to	TO
cord-006229-7yoilsho	2825	14	be	be	VB
cord-006229-7yoilsho	2825	15	involved	involve	VBN
cord-006229-7yoilsho	2825	16	in	in	IN
cord-006229-7yoilsho	2825	17	hormone	hormone	NN
cord-006229-7yoilsho	2825	18	release	release	NN
cord-006229-7yoilsho	2825	19	from	from	IN
cord-006229-7yoilsho	2825	20	pancreatic	pancreatic	JJ
cord-006229-7yoilsho	2825	21	islets	islet	NNS
cord-006229-7yoilsho	2825	22	and	and	CC
cord-006229-7yoilsho	2825	23	the	the	DT
cord-006229-7yoilsho	2825	24	pituitary	pituitary	JJ
cord-006229-7yoilsho	2825	25	gland	gland	NN
cord-006229-7yoilsho	2825	26	1,2	1,2	CD
cord-006229-7yoilsho	2825	27	.	.	.
cord-006229-7yoilsho	2826	1	The	the	DT
cord-006229-7yoilsho	2826	2	TRPM3	TRPM3	NNS
cord-006229-7yoilsho	2826	3	gene	gene	NN
cord-006229-7yoilsho	2826	4	encodes	encode	VBZ
cord-006229-7yoilsho	2826	5	a	a	DT
cord-006229-7yoilsho	2826	6	number	number	NN
cord-006229-7yoilsho	2826	7	of	of	IN
cord-006229-7yoilsho	2826	8	different	different	JJ
cord-006229-7yoilsho	2826	9	splice	splice	NN
cord-006229-7yoilsho	2826	10	variants	variant	NNS
cord-006229-7yoilsho	2826	11	that	that	WDT
cord-006229-7yoilsho	2826	12	differ	differ	VBP
cord-006229-7yoilsho	2826	13	in	in	IN
cord-006229-7yoilsho	2826	14	their	-PRON-	PRP$
cord-006229-7yoilsho	2826	15	permeation	permeation	NN
cord-006229-7yoilsho	2826	16	properties	property	NNS
cord-006229-7yoilsho	2826	17	and	and	CC
cord-006229-7yoilsho	2826	18	their	-PRON-	PRP$
cord-006229-7yoilsho	2826	19	activity	activity	NN
cord-006229-7yoilsho	2826	20	in	in	IN
cord-006229-7yoilsho	2826	21	response	response	NN
cord-006229-7yoilsho	2826	22	to	to	IN
cord-006229-7yoilsho	2826	23	agonists	agonist	NNS
cord-006229-7yoilsho	2826	24	3	3	CD
cord-006229-7yoilsho	2826	25	,	,	,
cord-006229-7yoilsho	2826	26	4	4	CD
cord-006229-7yoilsho	2826	27	.	.	.
cord-006229-7yoilsho	2827	1	Variations	variation	NNS
cord-006229-7yoilsho	2827	2	include	include	VBP
cord-006229-7yoilsho	2827	3	the	the	DT
cord-006229-7yoilsho	2827	4	presence	presence	NN
cord-006229-7yoilsho	2827	5	or	or	CC
cord-006229-7yoilsho	2827	6	absence	absence	NN
cord-006229-7yoilsho	2827	7	of	of	IN
cord-006229-7yoilsho	2827	8	five	five	CD
cord-006229-7yoilsho	2827	9	stretches	stretch	NNS
cord-006229-7yoilsho	2827	10	of	of	IN
cord-006229-7yoilsho	2827	11	10	10	CD
cord-006229-7yoilsho	2827	12	to	to	TO
cord-006229-7yoilsho	2827	13	25	25	CD
cord-006229-7yoilsho	2827	14	amino	amino	NN
cord-006229-7yoilsho	2827	15	acid	acid	NN
cord-006229-7yoilsho	2827	16	residues	residue	NNS
cord-006229-7yoilsho	2827	17	within	within	IN
cord-006229-7yoilsho	2827	18	the	the	DT
cord-006229-7yoilsho	2827	19	aminoterminus	aminoterminus	JJ
cord-006229-7yoilsho	2827	20	,	,	,
cord-006229-7yoilsho	2827	21	long	long	JJ
cord-006229-7yoilsho	2827	22	or	or	CC
cord-006229-7yoilsho	2827	23	short	short	JJ
cord-006229-7yoilsho	2827	24	pore	pore	NN
cord-006229-7yoilsho	2827	25	loops	loop	NNS
cord-006229-7yoilsho	2827	26	and	and	CC
cord-006229-7yoilsho	2827	27	long	long	JJ
cord-006229-7yoilsho	2827	28	or	or	CC
cord-006229-7yoilsho	2827	29	truncated	truncated	JJ
cord-006229-7yoilsho	2827	30	carboxytermini	carboxytermini	NNP
cord-006229-7yoilsho	2827	31	5	5	CD
cord-006229-7yoilsho	2827	32	.	.	.
cord-006229-7yoilsho	2828	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	2828	2	,	,	,
cord-006229-7yoilsho	2828	3	three	three	CD
cord-006229-7yoilsho	2828	4	different	different	JJ
cord-006229-7yoilsho	2828	5	aminotermini	aminotermini	NN
cord-006229-7yoilsho	2828	6	of	of	IN
cord-006229-7yoilsho	2828	7	human	human	NN
cord-006229-7yoilsho	2828	8	and	and	CC
cord-006229-7yoilsho	2828	9	mouse	mouse	NN
cord-006229-7yoilsho	2828	10	proteins	protein	NNS
cord-006229-7yoilsho	2828	11	have	have	VBP
cord-006229-7yoilsho	2828	12	been	be	VBN
cord-006229-7yoilsho	2828	13	described	describe	VBN
cord-006229-7yoilsho	2828	14	5	5	CD
cord-006229-7yoilsho	2828	15	,	,	,
cord-006229-7yoilsho	2828	16	but	but	CC
cord-006229-7yoilsho	2828	17	presumably	presumably	RB
cord-006229-7yoilsho	2828	18	these	these	DT
cord-006229-7yoilsho	2828	19	differences	difference	NNS
cord-006229-7yoilsho	2828	20	are	be	VBP
cord-006229-7yoilsho	2828	21	caused	cause	VBN
cord-006229-7yoilsho	2828	22	by	by	IN
cord-006229-7yoilsho	2828	23	the	the	DT
cord-006229-7yoilsho	2828	24	activity	activity	NN
cord-006229-7yoilsho	2828	25	of	of	IN
cord-006229-7yoilsho	2828	26	different	different	JJ
cord-006229-7yoilsho	2828	27	promoters	promoter	NNS
cord-006229-7yoilsho	2828	28	.	.	.
cord-006229-7yoilsho	2829	1	Screening	screening	NN
cord-006229-7yoilsho	2829	2	of	of	IN
cord-006229-7yoilsho	2829	3	a	a	DT
cord-006229-7yoilsho	2829	4	mouse	mouse	NN
cord-006229-7yoilsho	2829	5	pituitary	pituitary	NNP
cord-006229-7yoilsho	2829	6	gland	gland	NNP
cord-006229-7yoilsho	2829	7	cDNA	cDNA	NNP
cord-006229-7yoilsho	2829	8	library	library	NN
cord-006229-7yoilsho	2829	9	identified	identify	VBD
cord-006229-7yoilsho	2829	10	12	12	CD
cord-006229-7yoilsho	2829	11	variants	variant	NNS
cord-006229-7yoilsho	2829	12	that	that	WDT
cord-006229-7yoilsho	2829	13	differ	differ	VBP
cord-006229-7yoilsho	2829	14	in	in	IN
cord-006229-7yoilsho	2829	15	exons	exon	NNS
cord-006229-7yoilsho	2829	16	8	8	CD
cord-006229-7yoilsho	2829	17	,	,	,
cord-006229-7yoilsho	2829	18	13	13	CD
cord-006229-7yoilsho	2829	19	,	,	,
cord-006229-7yoilsho	2829	20	15	15	CD
cord-006229-7yoilsho	2829	21	,	,	,
cord-006229-7yoilsho	2829	22	17	17	CD
cord-006229-7yoilsho	2829	23	and	and	CC
cord-006229-7yoilsho	2829	24	20	20	CD
cord-006229-7yoilsho	2829	25	.	.	.
cord-006229-7yoilsho	2830	1	However	however	RB
cord-006229-7yoilsho	2830	2	,	,	,
cord-006229-7yoilsho	2830	3	only	only	RB
cord-006229-7yoilsho	2830	4	variants	variant	NNS
cord-006229-7yoilsho	2830	5	bearing	bear	VBG
cord-006229-7yoilsho	2830	6	the	the	DT
cord-006229-7yoilsho	2830	7	short	short	JJ
cord-006229-7yoilsho	2830	8	,	,	,
cord-006229-7yoilsho	2830	9	Ca	ca	NN
cord-006229-7yoilsho	2830	10	2	2	CD
cord-006229-7yoilsho	2830	11	+	+	SYM
cord-006229-7yoilsho	2830	12	permeable	permeable	JJ
cord-006229-7yoilsho	2830	13	pore	pore	NN
cord-006229-7yoilsho	2830	14	loop	loop	NN
cord-006229-7yoilsho	2830	15	were	be	VBD
cord-006229-7yoilsho	2830	16	detected	detect	VBN
cord-006229-7yoilsho	2830	17	.	.	.
cord-006229-7yoilsho	2831	1	3	3	LS
cord-006229-7yoilsho	2831	2	´	´	CD
cord-006229-7yoilsho	2831	3	rapid	rapid	JJ
cord-006229-7yoilsho	2831	4	amplification	amplification	NN
cord-006229-7yoilsho	2831	5	of	of	IN
cord-006229-7yoilsho	2831	6	cDNA	cdna	NN
cord-006229-7yoilsho	2831	7	ends	end	NNS
cord-006229-7yoilsho	2831	8	(	(	-LRB-
cord-006229-7yoilsho	2831	9	3´RACE	3´race	CD
cord-006229-7yoilsho	2831	10	)	)	-RRB-
cord-006229-7yoilsho	2831	11	revealed	reveal	VBD
cord-006229-7yoilsho	2831	12	that	that	IN
cord-006229-7yoilsho	2831	13	TRPM3	TRPM3	NNP
cord-006229-7yoilsho	2831	14	proteins	protein	NNS
cord-006229-7yoilsho	2831	15	of	of	IN
cord-006229-7yoilsho	2831	16	the	the	DT
cord-006229-7yoilsho	2831	17	pituitary	pituitary	JJ
cord-006229-7yoilsho	2831	18	gland	gland	NN
cord-006229-7yoilsho	2831	19	carry	carry	VBP
cord-006229-7yoilsho	2831	20	truncated	truncate	VBN
cord-006229-7yoilsho	2831	21	C	C	NNP
cord-006229-7yoilsho	2831	22	-	-	HYPH
cord-006229-7yoilsho	2831	23	termini	termini	NNP
cord-006229-7yoilsho	2831	24	exclusively	exclusively	RB
cord-006229-7yoilsho	2831	25	.	.	.
cord-006229-7yoilsho	2832	1	5´RACE	5´race	CD
cord-006229-7yoilsho	2832	2	identified	identify	VBD
cord-006229-7yoilsho	2832	3	five	five	CD
cord-006229-7yoilsho	2832	4	independent	independent	JJ
cord-006229-7yoilsho	2832	5	regions	region	NNS
cord-006229-7yoilsho	2832	6	of	of	IN
cord-006229-7yoilsho	2832	7	transcription	transcription	NN
cord-006229-7yoilsho	2832	8	initiation	initiation	NN
cord-006229-7yoilsho	2832	9	within	within	IN
cord-006229-7yoilsho	2832	10	the	the	DT
cord-006229-7yoilsho	2832	11	TRPM3	TRPM3	NNP
cord-006229-7yoilsho	2832	12	gene	gene	NN
cord-006229-7yoilsho	2832	13	implying	imply	VBG
cord-006229-7yoilsho	2832	14	the	the	DT
cord-006229-7yoilsho	2832	15	presence	presence	NN
cord-006229-7yoilsho	2832	16	of	of	IN
cord-006229-7yoilsho	2832	17	five	five	CD
cord-006229-7yoilsho	2832	18	independent	independent	JJ
cord-006229-7yoilsho	2832	19	promotors	promotor	NNS
cord-006229-7yoilsho	2832	20	.	.	.
cord-006229-7yoilsho	2833	1	The	the	DT
cord-006229-7yoilsho	2833	2	different	different	JJ
cord-006229-7yoilsho	2833	3	transcripts	transcript	NNS
cord-006229-7yoilsho	2833	4	encode	encode	VBP
cord-006229-7yoilsho	2833	5	four	four	CD
cord-006229-7yoilsho	2833	6	TRPM3	trpm3	NN
cord-006229-7yoilsho	2833	7	amino	amino	NNS
cord-006229-7yoilsho	2833	8	termini	termini	NN
cord-006229-7yoilsho	2833	9	α	α	NN
cord-006229-7yoilsho	2833	10	,	,	,
cord-006229-7yoilsho	2833	11	β	β	NN
cord-006229-7yoilsho	2833	12	,	,	,
cord-006229-7yoilsho	2833	13	γ	γ	NN
cord-006229-7yoilsho	2833	14	and	and	CC
cord-006229-7yoilsho	2833	15	δ	δ	NN
cord-006229-7yoilsho	2833	16	of	of	IN
cord-006229-7yoilsho	2833	17	1	1	CD
cord-006229-7yoilsho	2833	18	-	-	SYM
cord-006229-7yoilsho	2833	19	155	155	CD
cord-006229-7yoilsho	2833	20	amino	amino	NN
cord-006229-7yoilsho	2833	21	acid	acid	NN
cord-006229-7yoilsho	2833	22	residues	residue	NNS
cord-006229-7yoilsho	2833	23	including	include	VBG
cord-006229-7yoilsho	2833	24	those	those	DT
cord-006229-7yoilsho	2833	25	described	describe	VBN
cord-006229-7yoilsho	2833	26	in	in	IN
cord-006229-7yoilsho	2833	27	humans	human	NNS
cord-006229-7yoilsho	2833	28	(	(	-LRB-
cord-006229-7yoilsho	2833	29	β	β	NN
cord-006229-7yoilsho	2833	30	,	,	,
cord-006229-7yoilsho	2833	31	γ	γ	NNP
cord-006229-7yoilsho	2833	32	)	)	-RRB-
cord-006229-7yoilsho	2833	33	.	.	.
cord-006229-7yoilsho	2834	1	However	however	RB
cord-006229-7yoilsho	2834	2	,	,	,
cord-006229-7yoilsho	2834	3	the	the	DT
cord-006229-7yoilsho	2834	4	activity	activity	NN
cord-006229-7yoilsho	2834	5	of	of	IN
cord-006229-7yoilsho	2834	6	these	these	DT
cord-006229-7yoilsho	2834	7	variants	variant	NNS
cord-006229-7yoilsho	2834	8	after	after	IN
cord-006229-7yoilsho	2834	9	stimulation	stimulation	NN
cord-006229-7yoilsho	2834	10	with	with	IN
cord-006229-7yoilsho	2834	11	pregnenolone	pregnenolone	NN
cord-006229-7yoilsho	2834	12	sulfate	sulfate	NN
cord-006229-7yoilsho	2834	13	varied	vary	VBN
cord-006229-7yoilsho	2834	14	largely	largely	RB
cord-006229-7yoilsho	2834	15	just	just	RB
cord-006229-7yoilsho	2834	16	as	as	IN
cord-006229-7yoilsho	2834	17	their	-PRON-	PRP$
cord-006229-7yoilsho	2834	18	frequency	frequency	NN
cord-006229-7yoilsho	2834	19	in	in	IN
cord-006229-7yoilsho	2834	20	the	the	DT
cord-006229-7yoilsho	2834	21	pituitary	pituitary	NN
cord-006229-7yoilsho	2834	22	with	with	IN
cord-006229-7yoilsho	2834	23	shortened	shorten	VBN
cord-006229-7yoilsho	2834	24	γ	γ	NN
cord-006229-7yoilsho	2834	25	-	-	HYPH
cord-006229-7yoilsho	2834	26	variants	variant	NNS
cord-006229-7yoilsho	2834	27	being	be	VBG
cord-006229-7yoilsho	2834	28	most	most	RBS
cord-006229-7yoilsho	2834	29	abundant	abundant	JJ
cord-006229-7yoilsho	2834	30	(	(	-LRB-
cord-006229-7yoilsho	2834	31	~76	~76	NFP
cord-006229-7yoilsho	2834	32	%	%	NN
cord-006229-7yoilsho	2834	33	)	)	-RRB-
cord-006229-7yoilsho	2834	34	.	.	.
cord-006229-7yoilsho	2835	1	Two	two	CD
cord-006229-7yoilsho	2835	2	-	-	HYPH
cord-006229-7yoilsho	2835	3	pore	pore	NN
cord-006229-7yoilsho	2835	4	channels	channel	NNS
cord-006229-7yoilsho	2835	5	(	(	-LRB-
cord-006229-7yoilsho	2835	6	TPCs	tpc	NNS
cord-006229-7yoilsho	2835	7	)	)	-RRB-
cord-006229-7yoilsho	2835	8	are	be	VBP
cord-006229-7yoilsho	2835	9	a	a	DT
cord-006229-7yoilsho	2835	10	small	small	JJ
cord-006229-7yoilsho	2835	11	family	family	NN
cord-006229-7yoilsho	2835	12	of	of	IN
cord-006229-7yoilsho	2835	13	ion	ion	NN
cord-006229-7yoilsho	2835	14	-	-	HYPH
cord-006229-7yoilsho	2835	15	channels	channel	NNS
cord-006229-7yoilsho	2835	16	found	find	VBN
cord-006229-7yoilsho	2835	17	throughout	throughout	IN
cord-006229-7yoilsho	2835	18	the	the	DT
cord-006229-7yoilsho	2835	19	endolysosomal	endolysosomal	JJ
cord-006229-7yoilsho	2835	20	system	system	NN
cord-006229-7yoilsho	2835	21	of	of	IN
cord-006229-7yoilsho	2835	22	eukaryotic	eukaryotic	JJ
cord-006229-7yoilsho	2835	23	cells	cell	NNS
cord-006229-7yoilsho	2835	24	.	.	.
cord-006229-7yoilsho	2836	1	Phylogenetically	phylogenetically	RB
cord-006229-7yoilsho	2836	2	TPCs	tpc	NNS
cord-006229-7yoilsho	2836	3	belong	belong	VBP
cord-006229-7yoilsho	2836	4	to	to	IN
cord-006229-7yoilsho	2836	5	the	the	DT
cord-006229-7yoilsho	2836	6	voltagegated	voltagegate	VBN
cord-006229-7yoilsho	2836	7	ion	ion	NN
cord-006229-7yoilsho	2836	8	channel	channel	NN
cord-006229-7yoilsho	2836	9	superfamily	superfamily	NN
cord-006229-7yoilsho	2836	10	sharing	share	VBG
cord-006229-7yoilsho	2836	11	common	common	JJ
cord-006229-7yoilsho	2836	12	traits	trait	NNS
cord-006229-7yoilsho	2836	13	with	with	IN
cord-006229-7yoilsho	2836	14	Ca	Ca	NNP
cord-006229-7yoilsho	2836	15	v	v	NN
cord-006229-7yoilsho	2836	16	/	/	SYM
cord-006229-7yoilsho	2836	17	Na	Na	NNP
cord-006229-7yoilsho	2836	18	v	v	NN
cord-006229-7yoilsho	2836	19	and	and	CC
cord-006229-7yoilsho	2836	20	TRP	TRP	NNP
cord-006229-7yoilsho	2836	21	channels	channel	NNS
cord-006229-7yoilsho	2836	22	.	.	.
cord-006229-7yoilsho	2837	1	TPCs	tpc	NNS
cord-006229-7yoilsho	2837	2	show	show	VBP
cord-006229-7yoilsho	2837	3	a	a	DT
cord-006229-7yoilsho	2837	4	duplicated	duplicate	VBN
cord-006229-7yoilsho	2837	5	architecture	architecture	NN
cord-006229-7yoilsho	2837	6	with	with	IN
cord-006229-7yoilsho	2837	7	two	two	CD
cord-006229-7yoilsho	2837	8	homologous	homologous	JJ
cord-006229-7yoilsho	2837	9	trans	trans	NN
cord-006229-7yoilsho	2837	10	-	-	NN
cord-006229-7yoilsho	2837	11	membrane	membrane	NN
cord-006229-7yoilsho	2837	12	domains	domain	NNS
cord-006229-7yoilsho	2837	13	.	.	.
cord-006229-7yoilsho	2838	1	Each	each	DT
cord-006229-7yoilsho	2838	2	domain	domain	NN
cord-006229-7yoilsho	2838	3	is	be	VBZ
cord-006229-7yoilsho	2838	4	build	build	VB
cord-006229-7yoilsho	2838	5	up	up	RP
cord-006229-7yoilsho	2838	6	by	by	IN
cord-006229-7yoilsho	2838	7	six	six	CD
cord-006229-7yoilsho	2838	8	membrane	membrane	NN
cord-006229-7yoilsho	2838	9	spanning	span	VBG
cord-006229-7yoilsho	2838	10	alpha	alpha	NN
cord-006229-7yoilsho	2838	11	helices	helix	NNS
cord-006229-7yoilsho	2838	12	linked	link	VBN
cord-006229-7yoilsho	2838	13	by	by	IN
cord-006229-7yoilsho	2838	14	short	short	JJ
cord-006229-7yoilsho	2838	15	loops	loop	NNS
cord-006229-7yoilsho	2838	16	.	.	.
cord-006229-7yoilsho	2839	1	It	-PRON-	PRP
cord-006229-7yoilsho	2839	2	is	be	VBZ
cord-006229-7yoilsho	2839	3	very	very	RB
cord-006229-7yoilsho	2839	4	likely	likely	JJ
cord-006229-7yoilsho	2839	5	that	that	IN
cord-006229-7yoilsho	2839	6	TPCs	tpc	NNS
cord-006229-7yoilsho	2839	7	form	form	NN
cord-006229-7yoilsho	2839	8	dimers	dimer	NNS
cord-006229-7yoilsho	2839	9	maintaining	maintain	VBG
cord-006229-7yoilsho	2839	10	the	the	DT
cord-006229-7yoilsho	2839	11	four	four	CD
cord-006229-7yoilsho	2839	12	-	-	HYPH
cord-006229-7yoilsho	2839	13	fold	fold	JJ
cord-006229-7yoilsho	2839	14	symmetry	symmetry	NN
cord-006229-7yoilsho	2839	15	found	find	VBN
cord-006229-7yoilsho	2839	16	in	in	IN
cord-006229-7yoilsho	2839	17	other	other	JJ
cord-006229-7yoilsho	2839	18	members	member	NNS
cord-006229-7yoilsho	2839	19	of	of	IN
cord-006229-7yoilsho	2839	20	the	the	DT
cord-006229-7yoilsho	2839	21	voltage	voltage	NN
cord-006229-7yoilsho	2839	22	-	-	HYPH
cord-006229-7yoilsho	2839	23	gated	gate	VBN
cord-006229-7yoilsho	2839	24	ion	ion	NN
cord-006229-7yoilsho	2839	25	channel	channel	NN
cord-006229-7yoilsho	2839	26	superfamily	superfamily	NN
cord-006229-7yoilsho	2839	27	.	.	.
cord-006229-7yoilsho	2840	1	Due	due	IN
cord-006229-7yoilsho	2840	2	to	to	IN
cord-006229-7yoilsho	2840	3	their	-PRON-	PRP$
cord-006229-7yoilsho	2840	4	localization	localization	NN
cord-006229-7yoilsho	2840	5	in	in	IN
cord-006229-7yoilsho	2840	6	the	the	DT
cord-006229-7yoilsho	2840	7	endolysosomal	endolysosomal	JJ
cord-006229-7yoilsho	2840	8	system	system	NN
cord-006229-7yoilsho	2840	9	TPCs	tpc	NNS
cord-006229-7yoilsho	2840	10	are	be	VBP
cord-006229-7yoilsho	2840	11	not	not	RB
cord-006229-7yoilsho	2840	12	accessible	accessible	JJ
cord-006229-7yoilsho	2840	13	to	to	IN
cord-006229-7yoilsho	2840	14	conventional	conventional	JJ
cord-006229-7yoilsho	2840	15	patch	patch	NN
cord-006229-7yoilsho	2840	16	clamping	clamping	NN
cord-006229-7yoilsho	2840	17	.	.	.
cord-006229-7yoilsho	2841	1	To	to	TO
cord-006229-7yoilsho	2841	2	investigate	investigate	VB
cord-006229-7yoilsho	2841	3	TPCs	tpc	NNS
cord-006229-7yoilsho	2841	4	electrophysiological	electrophysiological	JJ
cord-006229-7yoilsho	2841	5	properties	property	NNS
cord-006229-7yoilsho	2841	6	we	-PRON-	PRP
cord-006229-7yoilsho	2841	7	use	use	VBP
cord-006229-7yoilsho	2841	8	black	black	JJ
cord-006229-7yoilsho	2841	9	lipid	lipid	NN
cord-006229-7yoilsho	2841	10	bilayer	bilayer	NN
cord-006229-7yoilsho	2841	11	measurements	measurement	NNS
cord-006229-7yoilsho	2841	12	.	.	.
cord-006229-7yoilsho	2842	1	Purified	purify	VBN
cord-006229-7yoilsho	2842	2	channels	channel	NNS
cord-006229-7yoilsho	2842	3	are	be	VBP
cord-006229-7yoilsho	2842	4	integrated	integrate	VBN
cord-006229-7yoilsho	2842	5	into	into	IN
cord-006229-7yoilsho	2842	6	an	an	DT
cord-006229-7yoilsho	2842	7	artificial	artificial	JJ
cord-006229-7yoilsho	2842	8	phospholipid	phospholipid	NN
cord-006229-7yoilsho	2842	9	bilayer	bilayer	NN
cord-006229-7yoilsho	2842	10	that	that	WDT
cord-006229-7yoilsho	2842	11	separates	separate	VBZ
cord-006229-7yoilsho	2842	12	two	two	CD
cord-006229-7yoilsho	2842	13	chambers	chamber	NNS
cord-006229-7yoilsho	2842	14	enabling	enable	VBG
cord-006229-7yoilsho	2842	15	us	-PRON-	PRP
cord-006229-7yoilsho	2842	16	to	to	TO
cord-006229-7yoilsho	2842	17	apply	apply	VB
cord-006229-7yoilsho	2842	18	different	different	JJ
cord-006229-7yoilsho	2842	19	buffers	buffer	NNS
cord-006229-7yoilsho	2842	20	.	.	.
cord-006229-7yoilsho	2843	1	Upon	upon	IN
cord-006229-7yoilsho	2843	2	activation	activation	NN
cord-006229-7yoilsho	2843	3	by	by	IN
cord-006229-7yoilsho	2843	4	NAADP	NAADP	NNP
cord-006229-7yoilsho	2843	5	ions	ion	NNS
cord-006229-7yoilsho	2843	6	flow	flow	VBP
cord-006229-7yoilsho	2843	7	through	through	IN
cord-006229-7yoilsho	2843	8	the	the	DT
cord-006229-7yoilsho	2843	9	channel	channel	NN
cord-006229-7yoilsho	2843	10	and	and	CC
cord-006229-7yoilsho	2843	11	can	can	MD
cord-006229-7yoilsho	2843	12	thereby	thereby	RB
cord-006229-7yoilsho	2843	13	pass	pass	VB
cord-006229-7yoilsho	2843	14	the	the	DT
cord-006229-7yoilsho	2843	15	diffusion	diffusion	NN
cord-006229-7yoilsho	2843	16	barrier	barrier	NN
cord-006229-7yoilsho	2843	17	.	.	.
cord-006229-7yoilsho	2844	1	The	the	DT
cord-006229-7yoilsho	2844	2	movement	movement	NN
cord-006229-7yoilsho	2844	3	of	of	IN
cord-006229-7yoilsho	2844	4	charged	charge	VBN
cord-006229-7yoilsho	2844	5	molecules	molecule	NNS
cord-006229-7yoilsho	2844	6	through	through	IN
cord-006229-7yoilsho	2844	7	TPCs	tpc	NNS
cord-006229-7yoilsho	2844	8	results	result	NNS
cord-006229-7yoilsho	2844	9	in	in	IN
cord-006229-7yoilsho	2844	10	currents	current	NNS
cord-006229-7yoilsho	2844	11	which	which	WDT
cord-006229-7yoilsho	2844	12	can	can	MD
cord-006229-7yoilsho	2844	13	be	be	VB
cord-006229-7yoilsho	2844	14	amplified	amplify	VBN
cord-006229-7yoilsho	2844	15	and	and	CC
cord-006229-7yoilsho	2844	16	recorded	record	VBN
cord-006229-7yoilsho	2844	17	.	.	.
cord-006229-7yoilsho	2845	1	The	the	DT
cord-006229-7yoilsho	2845	2	controlled	control	VBN
cord-006229-7yoilsho	2845	3	environment	environment	NN
cord-006229-7yoilsho	2845	4	of	of	IN
cord-006229-7yoilsho	2845	5	the	the	DT
cord-006229-7yoilsho	2845	6	lipid	lipid	NN
cord-006229-7yoilsho	2845	7	bilayer	bilayer	NN
cord-006229-7yoilsho	2845	8	setup	setup	NN
cord-006229-7yoilsho	2845	9	allows	allow	VBZ
cord-006229-7yoilsho	2845	10	testing	testing	NN
cord-006229-7yoilsho	2845	11	of	of	IN
cord-006229-7yoilsho	2845	12	different	different	JJ
cord-006229-7yoilsho	2845	13	ions	ion	NNS
cord-006229-7yoilsho	2845	14	as	as	RB
cord-006229-7yoilsho	2845	15	well	well	RB
cord-006229-7yoilsho	2845	16	as	as	IN
cord-006229-7yoilsho	2845	17	putative	putative	JJ
cord-006229-7yoilsho	2845	18	activating	activate	VBG
cord-006229-7yoilsho	2845	19	and	and	CC
cord-006229-7yoilsho	2845	20	inhibitory	inhibitory	JJ
cord-006229-7yoilsho	2845	21	substances	substance	NNS
cord-006229-7yoilsho	2845	22	.	.	.
cord-006229-7yoilsho	2846	1	One	one	CD
cord-006229-7yoilsho	2846	2	of	of	IN
cord-006229-7yoilsho	2846	3	the	the	DT
cord-006229-7yoilsho	2846	4	major	major	JJ
cord-006229-7yoilsho	2846	5	drawbacks	drawback	NNS
cord-006229-7yoilsho	2846	6	of	of	IN
cord-006229-7yoilsho	2846	7	conventional	conventional	JJ
cord-006229-7yoilsho	2846	8	lipid	lipid	NN
cord-006229-7yoilsho	2846	9	bilayer	bilayer	NN
cord-006229-7yoilsho	2846	10	setups	setup	NNS
cord-006229-7yoilsho	2846	11	are	be	VBP
cord-006229-7yoilsho	2846	12	long	long	JJ
cord-006229-7yoilsho	2846	13	preparation	preparation	NN
cord-006229-7yoilsho	2846	14	times	time	NNS
cord-006229-7yoilsho	2846	15	between	between	IN
cord-006229-7yoilsho	2846	16	each	each	DT
cord-006229-7yoilsho	2846	17	measurement	measurement	NN
cord-006229-7yoilsho	2846	18	.	.	.
cord-006229-7yoilsho	2847	1	Stability	stability	NN
cord-006229-7yoilsho	2847	2	of	of	IN
cord-006229-7yoilsho	2847	3	the	the	DT
cord-006229-7yoilsho	2847	4	phospholipid	phospholipid	NN
cord-006229-7yoilsho	2847	5	bilayer	bilayer	NN
cord-006229-7yoilsho	2847	6	can	can	MD
cord-006229-7yoilsho	2847	7	pose	pose	VB
cord-006229-7yoilsho	2847	8	another	another	DT
cord-006229-7yoilsho	2847	9	issue	issue	NN
cord-006229-7yoilsho	2847	10	.	.	.
cord-006229-7yoilsho	2848	1	Often	often	RB
cord-006229-7yoilsho	2848	2	several	several	JJ
cord-006229-7yoilsho	2848	3	membranes	membrane	NNS
cord-006229-7yoilsho	2848	4	have	have	VBP
cord-006229-7yoilsho	2848	5	to	to	TO
cord-006229-7yoilsho	2848	6	be	be	VB
cord-006229-7yoilsho	2848	7	established	establish	VBN
cord-006229-7yoilsho	2848	8	before	before	IN
cord-006229-7yoilsho	2848	9	a	a	DT
cord-006229-7yoilsho	2848	10	measurement	measurement	NN
cord-006229-7yoilsho	2848	11	can	can	MD
cord-006229-7yoilsho	2848	12	be	be	VB
cord-006229-7yoilsho	2848	13	performed	perform	VBN
cord-006229-7yoilsho	2848	14	making	make	VBG
cord-006229-7yoilsho	2848	15	it	-PRON-	PRP
cord-006229-7yoilsho	2848	16	very	very	RB
cord-006229-7yoilsho	2848	17	time	time	NN
cord-006229-7yoilsho	2848	18	consuming	consume	VBG
cord-006229-7yoilsho	2848	19	to	to	TO
cord-006229-7yoilsho	2848	20	achieve	achieve	VB
cord-006229-7yoilsho	2848	21	adequate	adequate	JJ
cord-006229-7yoilsho	2848	22	experiment	experiment	NN
cord-006229-7yoilsho	2848	23	numbers	number	NNS
cord-006229-7yoilsho	2848	24	.	.	.
cord-006229-7yoilsho	2849	1	New	new	JJ
cord-006229-7yoilsho	2849	2	multichannel	multichannel	JJ
cord-006229-7yoilsho	2849	3	systems	system	NNS
cord-006229-7yoilsho	2849	4	resolve	resolve	VB
cord-006229-7yoilsho	2849	5	this	this	DT
cord-006229-7yoilsho	2849	6	issue	issue	NN
cord-006229-7yoilsho	2849	7	supporting	support	VBG
cord-006229-7yoilsho	2849	8	fast	fast	JJ
cord-006229-7yoilsho	2849	9	formation	formation	NN
cord-006229-7yoilsho	2849	10	of	of	IN
cord-006229-7yoilsho	2849	11	bilayers	bilayer	NNS
cord-006229-7yoilsho	2849	12	while	while	IN
cord-006229-7yoilsho	2849	13	allowing	allow	VBG
cord-006229-7yoilsho	2849	14	measurement	measurement	NN
cord-006229-7yoilsho	2849	15	of	of	IN
cord-006229-7yoilsho	2849	16	up	up	IN
cord-006229-7yoilsho	2849	17	to	to	TO
cord-006229-7yoilsho	2849	18	16	16	CD
cord-006229-7yoilsho	2849	19	different	different	JJ
cord-006229-7yoilsho	2849	20	bilayers	bilayer	NNS
cord-006229-7yoilsho	2849	21	at	at	IN
cord-006229-7yoilsho	2849	22	a	a	DT
cord-006229-7yoilsho	2849	23	time	time	NN
cord-006229-7yoilsho	2849	24	.	.	.
cord-006229-7yoilsho	2850	1	Here	here	RB
cord-006229-7yoilsho	2850	2	we	-PRON-	PRP
cord-006229-7yoilsho	2850	3	utilize	utilize	VBP
cord-006229-7yoilsho	2850	4	the	the	DT
cord-006229-7yoilsho	2850	5	"	"	``
cord-006229-7yoilsho	2850	6	Orbit	Orbit	NNP
cord-006229-7yoilsho	2850	7	"	"	''
cord-006229-7yoilsho	2850	8	multichannel	multichannel	JJ
cord-006229-7yoilsho	2850	9	system	system	NN
cord-006229-7yoilsho	2850	10	with	with	IN
cord-006229-7yoilsho	2850	11	a	a	DT
cord-006229-7yoilsho	2850	12	MECA16	MECA16	NNP
cord-006229-7yoilsho	2850	13	chip	chip	NN
cord-006229-7yoilsho	2850	14	by	by	IN
cord-006229-7yoilsho	2850	15	Ionera	Ionera	NNP
cord-006229-7yoilsho	2850	16	to	to	TO
cord-006229-7yoilsho	2850	17	measure	measure	VB
cord-006229-7yoilsho	2850	18	TPC1	TPC1	NNP
cord-006229-7yoilsho	2850	19	channel	channel	NN
cord-006229-7yoilsho	2850	20	activity	activity	NN
cord-006229-7yoilsho	2850	21	.	.	.
cord-006229-7yoilsho	2851	1	We	-PRON-	PRP
cord-006229-7yoilsho	2851	2	will	will	MD
cord-006229-7yoilsho	2851	3	present	present	VB
cord-006229-7yoilsho	2851	4	data	datum	NNS
cord-006229-7yoilsho	2851	5	generated	generate	VBN
cord-006229-7yoilsho	2851	6	by	by	IN
cord-006229-7yoilsho	2851	7	the	the	DT
cord-006229-7yoilsho	2851	8	"	"	``
cord-006229-7yoilsho	2851	9	Orbit	Orbit	NNP
cord-006229-7yoilsho	2851	10	"	"	''
cord-006229-7yoilsho	2851	11	system	system	NN
cord-006229-7yoilsho	2851	12	and	and	CC
cord-006229-7yoilsho	2851	13	a	a	DT
cord-006229-7yoilsho	2851	14	conventional	conventional	JJ
cord-006229-7yoilsho	2851	15	bilayer	bilayer	NN
cord-006229-7yoilsho	2851	16	setup	setup	NN
cord-006229-7yoilsho	2851	17	using	use	VBG
cord-006229-7yoilsho	2851	18	different	different	JJ
cord-006229-7yoilsho	2851	19	channel	channel	NN
cord-006229-7yoilsho	2851	20	constructs	construct	NNS
cord-006229-7yoilsho	2851	21	and	and	CC
cord-006229-7yoilsho	2851	22	charge	charge	NN
cord-006229-7yoilsho	2851	23	carriers	carrier	NNS
cord-006229-7yoilsho	2851	24	.	.	.
cord-006229-7yoilsho	2852	1	Cardiac	cardiac	JJ
cord-006229-7yoilsho	2852	2	action	action	NN
cord-006229-7yoilsho	2852	3	potentials	potential	NNS
cord-006229-7yoilsho	2852	4	are	be	VBP
cord-006229-7yoilsho	2852	5	generated	generate	VBN
cord-006229-7yoilsho	2852	6	and	and	CC
cord-006229-7yoilsho	2852	7	propagated	propagate	VBN
cord-006229-7yoilsho	2852	8	through	through	IN
cord-006229-7yoilsho	2852	9	the	the	DT
cord-006229-7yoilsho	2852	10	coordinated	coordinated	JJ
cord-006229-7yoilsho	2852	11	activity	activity	NN
cord-006229-7yoilsho	2852	12	of	of	IN
cord-006229-7yoilsho	2852	13	multiple	multiple	JJ
cord-006229-7yoilsho	2852	14	ion	ion	NN
cord-006229-7yoilsho	2852	15	channels	channel	NNS
cord-006229-7yoilsho	2852	16	,	,	,
cord-006229-7yoilsho	2852	17	including	include	VBG
cord-006229-7yoilsho	2852	18	voltage	voltage	NN
cord-006229-7yoilsho	2852	19	-	-	HYPH
cord-006229-7yoilsho	2852	20	gated	gate	VBN
cord-006229-7yoilsho	2852	21	sodium	sodium	NN
cord-006229-7yoilsho	2852	22	channels	channel	NNS
cord-006229-7yoilsho	2852	23	(	(	-LRB-
cord-006229-7yoilsho	2852	24	Nav1	Nav1	NNP
cord-006229-7yoilsho	2852	25	)	)	-RRB-
cord-006229-7yoilsho	2852	26	and	and	CC
cord-006229-7yoilsho	2852	27	potassium	potassium	NN
cord-006229-7yoilsho	2852	28	channels	channel	NNS
cord-006229-7yoilsho	2852	29	(	(	-LRB-
cord-006229-7yoilsho	2852	30	like	like	IN
cord-006229-7yoilsho	2852	31	Kv1	kv1	CD
cord-006229-7yoilsho	2852	32	,	,	,
cord-006229-7yoilsho	2852	33	Kv4	kv4	CD
cord-006229-7yoilsho	2852	34	)	)	-RRB-
cord-006229-7yoilsho	2852	35	.	.	.
cord-006229-7yoilsho	2853	1	The	the	DT
cord-006229-7yoilsho	2853	2	voltage	voltage	NN
cord-006229-7yoilsho	2853	3	-	-	HYPH
cord-006229-7yoilsho	2853	4	gated	gate	VBN
cord-006229-7yoilsho	2853	5	Na	Na	NNP
cord-006229-7yoilsho	2853	6	+	+	CC
cord-006229-7yoilsho	2854	1	channel	channel	NNP
cord-006229-7yoilsho	2854	2	Nav1.5	Nav1.5	NNP
cord-006229-7yoilsho	2854	3	initiates	initiate	VBZ
cord-006229-7yoilsho	2854	4	the	the	DT
cord-006229-7yoilsho	2854	5	cardiac	cardiac	JJ
cord-006229-7yoilsho	2854	6	action	action	NN
cord-006229-7yoilsho	2854	7	potential	potential	NN
cord-006229-7yoilsho	2854	8	(	(	-LRB-
cord-006229-7yoilsho	2854	9	AP	AP	NNP
cord-006229-7yoilsho	2854	10	)	)	-RRB-
cord-006229-7yoilsho	2854	11	,	,	,
cord-006229-7yoilsho	2854	12	is	be	VBZ
cord-006229-7yoilsho	2854	13	essential	essential	JJ
cord-006229-7yoilsho	2854	14	for	for	IN
cord-006229-7yoilsho	2854	15	rapid	rapid	JJ
cord-006229-7yoilsho	2854	16	depolarization	depolarization	NN
cord-006229-7yoilsho	2854	17	,	,	,
cord-006229-7yoilsho	2854	18	and	and	CC
cord-006229-7yoilsho	2854	19	is	be	VBZ
cord-006229-7yoilsho	2854	20	also	also	RB
cord-006229-7yoilsho	2854	21	known	know	VBN
cord-006229-7yoilsho	2854	22	to	to	TO
cord-006229-7yoilsho	2854	23	control	control	VB
cord-006229-7yoilsho	2854	24	the	the	DT
cord-006229-7yoilsho	2854	25	AP	AP	NNP
cord-006229-7yoilsho	2854	26	duration	duration	NN
cord-006229-7yoilsho	2854	27	in	in	IN
cord-006229-7yoilsho	2854	28	cardiomyocytes	cardiomyocyte	NNS
cord-006229-7yoilsho	2854	29	.	.	.
cord-006229-7yoilsho	2855	1	The	the	DT
cord-006229-7yoilsho	2855	2	voltage	voltage	NN
cord-006229-7yoilsho	2855	3	-	-	HYPH
cord-006229-7yoilsho	2855	4	gated	gate	VBN
cord-006229-7yoilsho	2855	5	K	K	NNP
cord-006229-7yoilsho	2855	6	+	+	CC
cord-006229-7yoilsho	2855	7	channel	channel	NN
cord-006229-7yoilsho	2855	8	Kv4.3	Kv4.3	NNPS
cord-006229-7yoilsho	2855	9	is	be	VBZ
cord-006229-7yoilsho	2855	10	responsible	responsible	JJ
cord-006229-7yoilsho	2855	11	for	for	IN
cord-006229-7yoilsho	2855	12	the	the	DT
cord-006229-7yoilsho	2855	13	early	early	JJ
cord-006229-7yoilsho	2855	14	repolarization	repolarization	NN
cord-006229-7yoilsho	2855	15	of	of	IN
cord-006229-7yoilsho	2855	16	action	action	NN
cord-006229-7yoilsho	2855	17	potentials	potential	NNS
cord-006229-7yoilsho	2855	18	in	in	IN
cord-006229-7yoilsho	2855	19	human	human	JJ
cord-006229-7yoilsho	2855	20	heart	heart	NN
cord-006229-7yoilsho	2855	21	.	.	.
cord-006229-7yoilsho	2856	1	Similar	similar	JJ
cord-006229-7yoilsho	2856	2	to	to	IN
cord-006229-7yoilsho	2856	3	many	many	JJ
cord-006229-7yoilsho	2856	4	membrane	membrane	NN
cord-006229-7yoilsho	2856	5	proteins	protein	NNS
cord-006229-7yoilsho	2856	6	,	,	,
cord-006229-7yoilsho	2856	7	Nav1.5	Nav1.5	NNP
cord-006229-7yoilsho	2856	8	and	and	CC
cord-006229-7yoilsho	2856	9	Kv4.3	Kv4.3	NNPS
cord-006229-7yoilsho	2856	10	have	have	VBP
cord-006229-7yoilsho	2856	11	been	be	VBN
cord-006229-7yoilsho	2856	12	found	find	VBN
cord-006229-7yoilsho	2856	13	to	to	TO
cord-006229-7yoilsho	2856	14	be	be	VB
cord-006229-7yoilsho	2856	15	regulated	regulate	VBN
cord-006229-7yoilsho	2856	16	by	by	IN
cord-006229-7yoilsho	2856	17	several	several	JJ
cord-006229-7yoilsho	2856	18	interacting	interact	VBG
cord-006229-7yoilsho	2856	19	proteins	protein	NNS
cord-006229-7yoilsho	2856	20	.	.	.
cord-006229-7yoilsho	2857	1	The	the	DT
cord-006229-7yoilsho	2857	2	transmembrane	transmembrane	NN
cord-006229-7yoilsho	2857	3	β	β	XX
cord-006229-7yoilsho	2857	4	subunit	subunit	NN
cord-006229-7yoilsho	2857	5	dipeptidyl	dipeptidyl	VBD
cord-006229-7yoilsho	2857	6	aminopepidase	aminopepidase	NNP
cord-006229-7yoilsho	2857	7	-	-	HYPH
cord-006229-7yoilsho	2857	8	like	like	JJ
cord-006229-7yoilsho	2857	9	protein	protein	NN
cord-006229-7yoilsho	2857	10	(	(	-LRB-
cord-006229-7yoilsho	2857	11	DPP	DPP	NNP
cord-006229-7yoilsho	2857	12	)	)	-RRB-
cord-006229-7yoilsho	2857	13	10	10	CD
cord-006229-7yoilsho	2857	14	is	be	VBZ
cord-006229-7yoilsho	2857	15	known	know	VBN
cord-006229-7yoilsho	2857	16	to	to	TO
cord-006229-7yoilsho	2857	17	interact	interact	VB
cord-006229-7yoilsho	2857	18	with	with	IN
cord-006229-7yoilsho	2857	19	the	the	DT
cord-006229-7yoilsho	2857	20	Kv4.3	Kv4.3	NNP
cord-006229-7yoilsho	2857	21	channel	channel	NN
cord-006229-7yoilsho	2857	22	complex	complex	NN
cord-006229-7yoilsho	2857	23	,	,	,
cord-006229-7yoilsho	2857	24	modulating	modulate	VBG
cord-006229-7yoilsho	2857	25	kinetics	kinetic	NNS
cord-006229-7yoilsho	2857	26	and	and	CC
cord-006229-7yoilsho	2857	27	voltage	voltage	VB
cord-006229-7yoilsho	2857	28	dependence	dependence	NN
cord-006229-7yoilsho	2857	29	.	.	.
cord-006229-7yoilsho	2858	1	The	the	DT
cord-006229-7yoilsho	2858	2	overexpression	overexpression	NN
cord-006229-7yoilsho	2858	3	of	of	IN
cord-006229-7yoilsho	2858	4	DPP10	DPP10	NNS
cord-006229-7yoilsho	2858	5	in	in	IN
cord-006229-7yoilsho	2858	6	ventricular	ventricular	JJ
cord-006229-7yoilsho	2858	7	cardiomyocytes	cardiomyocyte	NNS
cord-006229-7yoilsho	2858	8	of	of	IN
cord-006229-7yoilsho	2858	9	rats	rat	NNS
cord-006229-7yoilsho	2858	10	revealed	reveal	VBD
cord-006229-7yoilsho	2858	11	strong	strong	JJ
cord-006229-7yoilsho	2858	12	reduction	reduction	NN
cord-006229-7yoilsho	2858	13	of	of	IN
cord-006229-7yoilsho	2858	14	AP	AP	NNP
cord-006229-7yoilsho	2858	15	amplitude	amplitude	NN
cord-006229-7yoilsho	2858	16	and	and	CC
cord-006229-7yoilsho	2858	17	significant	significant	JJ
cord-006229-7yoilsho	2858	18	slowing	slowing	NN
cord-006229-7yoilsho	2858	19	of	of	IN
cord-006229-7yoilsho	2858	20	AP	AP	NNP
cord-006229-7yoilsho	2858	21	upstroke	upstroke	NN
cord-006229-7yoilsho	2858	22	velocity	velocity	NN
cord-006229-7yoilsho	2858	23	and	and	CC
cord-006229-7yoilsho	2858	24	AP	AP	NNP
cord-006229-7yoilsho	2858	25	duration	duration	NN
cord-006229-7yoilsho	2858	26	,	,	,
cord-006229-7yoilsho	2858	27	which	which	WDT
cord-006229-7yoilsho	2858	28	could	could	MD
cord-006229-7yoilsho	2858	29	not	not	RB
cord-006229-7yoilsho	2858	30	be	be	VB
cord-006229-7yoilsho	2858	31	explained	explain	VBN
cord-006229-7yoilsho	2858	32	by	by	IN
cord-006229-7yoilsho	2858	33	the	the	DT
cord-006229-7yoilsho	2858	34	effects	effect	NNS
cord-006229-7yoilsho	2858	35	on	on	IN
cord-006229-7yoilsho	2858	36	cardiac	cardiac	JJ
cord-006229-7yoilsho	2858	37	Kv4	kv4	JJ
cord-006229-7yoilsho	2858	38	channels	channel	NNS
cord-006229-7yoilsho	2858	39	.	.	.
cord-006229-7yoilsho	2859	1	To	to	TO
cord-006229-7yoilsho	2859	2	study	study	VB
cord-006229-7yoilsho	2859	3	the	the	DT
cord-006229-7yoilsho	2859	4	potential	potential	JJ
cord-006229-7yoilsho	2859	5	influence	influence	NN
cord-006229-7yoilsho	2859	6	of	of	IN
cord-006229-7yoilsho	2859	7	DPP10	DPP10	NNS
cord-006229-7yoilsho	2859	8	on	on	IN
cord-006229-7yoilsho	2859	9	Nav1.5	nav1.5	NN
cord-006229-7yoilsho	2859	10	channels	channel	NNS
cord-006229-7yoilsho	2859	11	,	,	,
cord-006229-7yoilsho	2859	12	we	-PRON-	PRP
cord-006229-7yoilsho	2859	13	performed	perform	VBD
cord-006229-7yoilsho	2859	14	whole	whole	JJ
cord-006229-7yoilsho	2859	15	-	-	HYPH
cord-006229-7yoilsho	2859	16	cell	cell	NN
cord-006229-7yoilsho	2859	17	patch	patch	NN
cord-006229-7yoilsho	2859	18	-	-	HYPH
cord-006229-7yoilsho	2859	19	clamp	clamp	NN
cord-006229-7yoilsho	2859	20	analysis	analysis	NN
cord-006229-7yoilsho	2859	21	of	of	IN
cord-006229-7yoilsho	2859	22	transiently	transiently	RB
cord-006229-7yoilsho	2859	23	transfected	transfecte	VBN
cord-006229-7yoilsho	2859	24	CHO	CHO	NNP
cord-006229-7yoilsho	2859	25	-	-	HYPH
cord-006229-7yoilsho	2859	26	K1	K1	NNP
cord-006229-7yoilsho	2859	27	cells	cell	NNS
cord-006229-7yoilsho	2859	28	,	,	,
cord-006229-7yoilsho	2859	29	expressing	express	VBG
cord-006229-7yoilsho	2859	30	SCN5A	SCN5A	NNS
cord-006229-7yoilsho	2859	31	alone	alone	RB
cord-006229-7yoilsho	2859	32	or	or	CC
cord-006229-7yoilsho	2859	33	with	with	IN
cord-006229-7yoilsho	2859	34	DPP10	DPP10	NNS
cord-006229-7yoilsho	2859	35	.	.	.
cord-006229-7yoilsho	2860	1	Surprisingly	surprisingly	RB
cord-006229-7yoilsho	2860	2	,	,	,
cord-006229-7yoilsho	2860	3	we	-PRON-	PRP
cord-006229-7yoilsho	2860	4	observed	observe	VBD
cord-006229-7yoilsho	2860	5	significant	significant	JJ
cord-006229-7yoilsho	2860	6	effects	effect	NNS
cord-006229-7yoilsho	2860	7	of	of	IN
cord-006229-7yoilsho	2860	8	DPP10	DPP10	NNS
cord-006229-7yoilsho	2860	9	on	on	IN
cord-006229-7yoilsho	2860	10	Nav1.5	Nav1.5	NNP
cord-006229-7yoilsho	2860	11	channel	channel	NN
cord-006229-7yoilsho	2860	12	voltage	voltage	NN
cord-006229-7yoilsho	2860	13	dependence	dependence	NN
cord-006229-7yoilsho	2860	14	and	and	CC
cord-006229-7yoilsho	2860	15	kinetics	kinetics	NN
cord-006229-7yoilsho	2860	16	.	.	.
cord-006229-7yoilsho	2861	1	Thus	thus	RB
cord-006229-7yoilsho	2861	2	,	,	,
cord-006229-7yoilsho	2861	3	the	the	DT
cord-006229-7yoilsho	2861	4	co	co	NN
cord-006229-7yoilsho	2861	5	-	-	NN
cord-006229-7yoilsho	2861	6	expression	expression	NN
cord-006229-7yoilsho	2861	7	of	of	IN
cord-006229-7yoilsho	2861	8	DPP10	DPP10	NNS
cord-006229-7yoilsho	2861	9	significantly	significantly	RB
cord-006229-7yoilsho	2861	10	shifted	shift	VBD
cord-006229-7yoilsho	2861	11	the	the	DT
cord-006229-7yoilsho	2861	12	half	half	RB
cord-006229-7yoilsho	2861	13	-	-	HYPH
cord-006229-7yoilsho	2861	14	maximal	maximal	JJ
cord-006229-7yoilsho	2861	15	voltage	voltage	NN
cord-006229-7yoilsho	2861	16	of	of	IN
cord-006229-7yoilsho	2861	17	steady	steady	JJ
cord-006229-7yoilsho	2861	18	-	-	HYPH
cord-006229-7yoilsho	2861	19	state	state	NN
cord-006229-7yoilsho	2861	20	activation	activation	NN
cord-006229-7yoilsho	2861	21	and	and	CC
cord-006229-7yoilsho	2861	22	steady	steady	JJ
cord-006229-7yoilsho	2861	23	-	-	HYPH
cord-006229-7yoilsho	2861	24	stateinactivation	stateinactivation	NN
cord-006229-7yoilsho	2861	25	to	to	IN
cord-006229-7yoilsho	2861	26	more	more	RBR
cord-006229-7yoilsho	2861	27	positive	positive	JJ
cord-006229-7yoilsho	2861	28	potentials	potential	NNS
cord-006229-7yoilsho	2861	29	compared	compare	VBN
cord-006229-7yoilsho	2861	30	to	to	IN
cord-006229-7yoilsho	2861	31	Nav1.5	nav1.5	CD
cord-006229-7yoilsho	2861	32	channels	channel	NNS
cord-006229-7yoilsho	2861	33	alone	alone	RB
cord-006229-7yoilsho	2861	34	.	.	.
cord-006229-7yoilsho	2862	1	In	in	IN
cord-006229-7yoilsho	2862	2	addition	addition	NN
cord-006229-7yoilsho	2862	3	we	-PRON-	PRP
cord-006229-7yoilsho	2862	4	analysed	analyse	VBD
cord-006229-7yoilsho	2862	5	the	the	DT
cord-006229-7yoilsho	2862	6	effects	effect	NNS
cord-006229-7yoilsho	2862	7	of	of	IN
cord-006229-7yoilsho	2862	8	DPP10	DPP10	NNS
cord-006229-7yoilsho	2862	9	on	on	IN
cord-006229-7yoilsho	2862	10	the	the	DT
cord-006229-7yoilsho	2862	11	kinetics	kinetic	NNS
cord-006229-7yoilsho	2862	12	Nav1.5	Nav1.5	NNP
cord-006229-7yoilsho	2862	13	currents	current	NNS
cord-006229-7yoilsho	2862	14	.	.	.
cord-006229-7yoilsho	2863	1	While	while	IN
cord-006229-7yoilsho	2863	2	time	time	NN
cord-006229-7yoilsho	2863	3	to	to	IN
cord-006229-7yoilsho	2863	4	current	current	JJ
cord-006229-7yoilsho	2863	5	peak	peak	NN
cord-006229-7yoilsho	2863	6	was	be	VBD
cord-006229-7yoilsho	2863	7	not	not	RB
cord-006229-7yoilsho	2863	8	affected	affect	VBN
cord-006229-7yoilsho	2863	9	in	in	IN
cord-006229-7yoilsho	2863	10	cells	cell	NNS
cord-006229-7yoilsho	2863	11	co	co	VBD
cord-006229-7yoilsho	2863	12	-	-	JJ
cord-006229-7yoilsho	2863	13	expressing	express	VBG
cord-006229-7yoilsho	2863	14	Nav1.5	Nav1.5	NNP
cord-006229-7yoilsho	2863	15	and	and	CC
cord-006229-7yoilsho	2863	16	DPP10	DPP10	NNS
cord-006229-7yoilsho	2863	17	compared	compare	VBN
cord-006229-7yoilsho	2863	18	to	to	IN
cord-006229-7yoilsho	2863	19	Nav1.5	nav1.5	NN
cord-006229-7yoilsho	2863	20	alone	alone	RB
cord-006229-7yoilsho	2863	21	,	,	,
cord-006229-7yoilsho	2863	22	DPP10	DPP10	NNS
cord-006229-7yoilsho	2863	23	slightly	slightly	RB
cord-006229-7yoilsho	2863	24	accelerated	accelerate	VBD
cord-006229-7yoilsho	2863	25	the	the	DT
cord-006229-7yoilsho	2863	26	inactivation	inactivation	NN
cord-006229-7yoilsho	2863	27	.	.	.
cord-006229-7yoilsho	2864	1	In	in	IN
cord-006229-7yoilsho	2864	2	addition	addition	NN
cord-006229-7yoilsho	2864	3	,	,	,
cord-006229-7yoilsho	2864	4	the	the	DT
cord-006229-7yoilsho	2864	5	time	time	NN
cord-006229-7yoilsho	2864	6	course	course	NN
cord-006229-7yoilsho	2864	7	of	of	IN
cord-006229-7yoilsho	2864	8	recovery	recovery	NN
cord-006229-7yoilsho	2864	9	from	from	IN
cord-006229-7yoilsho	2864	10	inactivation	inactivation	NN
cord-006229-7yoilsho	2864	11	was	be	VBD
cord-006229-7yoilsho	2864	12	clearly	clearly	RB
cord-006229-7yoilsho	2864	13	accelerated	accelerate	VBN
cord-006229-7yoilsho	2864	14	in	in	IN
cord-006229-7yoilsho	2864	15	cells	cell	NNS
cord-006229-7yoilsho	2864	16	expressing	express	VBG
cord-006229-7yoilsho	2864	17	both	both	CC
cord-006229-7yoilsho	2864	18	Nav1.5	Nav1.5	NNP
cord-006229-7yoilsho	2864	19	and	and	CC
cord-006229-7yoilsho	2864	20	DPP10	DPP10	NNS
cord-006229-7yoilsho	2864	21	compared	compare	VBN
cord-006229-7yoilsho	2864	22	to	to	IN
cord-006229-7yoilsho	2864	23	Nav1.5	nav1.5	NN
cord-006229-7yoilsho	2864	24	alone	alone	JJ
cord-006229-7yoilsho	2864	25	.	.	.
cord-006229-7yoilsho	2865	1	In	in	IN
cord-006229-7yoilsho	2865	2	summary	summary	NN
cord-006229-7yoilsho	2865	3	,	,	,
cord-006229-7yoilsho	2865	4	we	-PRON-	PRP
cord-006229-7yoilsho	2865	5	provide	provide	VBP
cord-006229-7yoilsho	2865	6	first	first	JJ
cord-006229-7yoilsho	2865	7	evidence	evidence	NN
cord-006229-7yoilsho	2865	8	that	that	IN
cord-006229-7yoilsho	2865	9	DPP10	DPP10	NNS
cord-006229-7yoilsho	2865	10	not	not	RB
cord-006229-7yoilsho	2865	11	only	only	RB
cord-006229-7yoilsho	2865	12	interacts	interact	VBZ
cord-006229-7yoilsho	2865	13	with	with	IN
cord-006229-7yoilsho	2865	14	Kv4	kv4	JJ
cord-006229-7yoilsho	2865	15	channels	channel	NNS
cord-006229-7yoilsho	2865	16	,	,	,
cord-006229-7yoilsho	2865	17	but	but	CC
cord-006229-7yoilsho	2865	18	also	also	RB
cord-006229-7yoilsho	2865	19	influences	influence	VBZ
cord-006229-7yoilsho	2865	20	Nav1.5	nav1.5	NN
cord-006229-7yoilsho	2865	21	channels	channel	NNS
cord-006229-7yoilsho	2865	22	modulating	modulate	VBG
cord-006229-7yoilsho	2865	23	the	the	DT
cord-006229-7yoilsho	2865	24	depolarization	depolarization	NN
cord-006229-7yoilsho	2865	25	as	as	RB
cord-006229-7yoilsho	2865	26	well	well	RB
cord-006229-7yoilsho	2865	27	as	as	IN
cord-006229-7yoilsho	2865	28	the	the	DT
cord-006229-7yoilsho	2865	29	early	early	JJ
cord-006229-7yoilsho	2865	30	repolarization	repolarization	NN
cord-006229-7yoilsho	2865	31	phase	phase	NN
cord-006229-7yoilsho	2865	32	of	of	IN
cord-006229-7yoilsho	2865	33	the	the	DT
cord-006229-7yoilsho	2865	34	cardiac	cardiac	JJ
cord-006229-7yoilsho	2865	35	AP	AP	NNP
cord-006229-7yoilsho	2865	36	.	.	.
cord-006229-7yoilsho	2866	1	Therefore	therefore	RB
cord-006229-7yoilsho	2866	2	,	,	,
cord-006229-7yoilsho	2866	3	it	-PRON-	PRP
cord-006229-7yoilsho	2866	4	becomes	become	VBZ
cord-006229-7yoilsho	2866	5	likely	likely	JJ
cord-006229-7yoilsho	2866	6	that	that	IN
cord-006229-7yoilsho	2866	7	these	these	DT
cord-006229-7yoilsho	2866	8	ion	ion	NN
cord-006229-7yoilsho	2866	9	channels	channel	NNS
cord-006229-7yoilsho	2866	10	are	be	VBP
cord-006229-7yoilsho	2866	11	part	part	NN
cord-006229-7yoilsho	2866	12	of	of	IN
cord-006229-7yoilsho	2866	13	large	large	JJ
cord-006229-7yoilsho	2866	14	,	,	,
cord-006229-7yoilsho	2866	15	multi	multi	JJ
cord-006229-7yoilsho	2866	16	-	-	JJ
cord-006229-7yoilsho	2866	17	protein	protein	JJ
cord-006229-7yoilsho	2866	18	complexes	complex	NNS
cord-006229-7yoilsho	2866	19	,	,	,
cord-006229-7yoilsho	2866	20	and	and	CC
cord-006229-7yoilsho	2866	21	that	that	IN
cord-006229-7yoilsho	2866	22	the	the	DT
cord-006229-7yoilsho	2866	23	pore	pore	NN
cord-006229-7yoilsho	2866	24	-	-	HYPH
cord-006229-7yoilsho	2866	25	forming	form	VBG
cord-006229-7yoilsho	2866	26	subunits	subunit	NNS
cord-006229-7yoilsho	2866	27	Kv4.3	Kv4.3	NNPS
cord-006229-7yoilsho	2866	28	and	and	CC
cord-006229-7yoilsho	2866	29	Nav1.5	Nav1.5	NNS
cord-006229-7yoilsho	2866	30	behave	behave	VBP
cord-006229-7yoilsho	2866	31	very	very	RB
cord-006229-7yoilsho	2866	32	differently	differently	RB
cord-006229-7yoilsho	2866	33	depending	depend	VBG
cord-006229-7yoilsho	2866	34	on	on	IN
cord-006229-7yoilsho	2866	35	the	the	DT
cord-006229-7yoilsho	2866	36	expression	expression	NN
cord-006229-7yoilsho	2866	37	of	of	IN
cord-006229-7yoilsho	2866	38	its	-PRON-	PRP$
cord-006229-7yoilsho	2866	39	associated	associate	VBN
cord-006229-7yoilsho	2866	40	proteins	protein	NNS
cord-006229-7yoilsho	2866	41	like	like	IN
cord-006229-7yoilsho	2866	42	DPP10	DPP10	NNS
cord-006229-7yoilsho	2866	43	.	.	.
cord-006229-7yoilsho	2867	1	Cardiac	cardiac	JJ
cord-006229-7yoilsho	2867	2	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	2867	3	(	(	-LRB-
cord-006229-7yoilsho	2867	4	CF	CF	NNP
cord-006229-7yoilsho	2867	5	)	)	-RRB-
cord-006229-7yoilsho	2867	6	comprise	comprise	VBP
cord-006229-7yoilsho	2867	7	the	the	DT
cord-006229-7yoilsho	2867	8	most	most	RBS
cord-006229-7yoilsho	2867	9	abundant	abundant	JJ
cord-006229-7yoilsho	2867	10	cell	cell	NN
cord-006229-7yoilsho	2867	11	type	type	NN
cord-006229-7yoilsho	2867	12	of	of	IN
cord-006229-7yoilsho	2867	13	the	the	DT
cord-006229-7yoilsho	2867	14	mammalian	mammalian	JJ
cord-006229-7yoilsho	2867	15	heart	heart	NN
cord-006229-7yoilsho	2867	16	and	and	CC
cord-006229-7yoilsho	2867	17	it	-PRON-	PRP
cord-006229-7yoilsho	2867	18	is	be	VBZ
cord-006229-7yoilsho	2867	19	known	know	VBN
cord-006229-7yoilsho	2867	20	that	that	IN
cord-006229-7yoilsho	2867	21	they	-PRON-	PRP
cord-006229-7yoilsho	2867	22	contribute	contribute	VBP
cord-006229-7yoilsho	2867	23	to	to	IN
cord-006229-7yoilsho	2867	24	maladaptive	maladaptive	JJ
cord-006229-7yoilsho	2867	25	cardiac	cardiac	JJ
cord-006229-7yoilsho	2867	26	remodeling	remodeling	NN
cord-006229-7yoilsho	2867	27	processes	process	NNS
cord-006229-7yoilsho	2867	28	.	.	.
cord-006229-7yoilsho	2868	1	In	in	IN
cord-006229-7yoilsho	2868	2	response	response	NN
cord-006229-7yoilsho	2868	3	to	to	IN
cord-006229-7yoilsho	2868	4	pressure	pressure	NN
cord-006229-7yoilsho	2868	5	or	or	CC
cord-006229-7yoilsho	2868	6	volume	volume	NN
cord-006229-7yoilsho	2868	7	overload	overload	NN
cord-006229-7yoilsho	2868	8	,	,	,
cord-006229-7yoilsho	2868	9	ischemia	ischemia	NN
cord-006229-7yoilsho	2868	10	-	-	HYPH
cord-006229-7yoilsho	2868	11	reperfusion	reperfusion	NN
cord-006229-7yoilsho	2868	12	injury	injury	NN
cord-006229-7yoilsho	2868	13	or	or	CC
cord-006229-7yoilsho	2868	14	myocardial	myocardial	JJ
cord-006229-7yoilsho	2868	15	infarction	infarction	NN
cord-006229-7yoilsho	2868	16	,	,	,
cord-006229-7yoilsho	2868	17	cardiac	cardiac	NN
cord-006229-7yoilsho	2868	18	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	2868	19	proliferate	proliferate	VBP
cord-006229-7yoilsho	2868	20	and	and	CC
cord-006229-7yoilsho	2868	21	transdifferentiate	transdifferentiate	NNP
cord-006229-7yoilsho	2868	22	into	into	IN
cord-006229-7yoilsho	2868	23	myofibroblasts	myofibroblast	NNS
cord-006229-7yoilsho	2868	24	which	which	WDT
cord-006229-7yoilsho	2868	25	produce	produce	VBP
cord-006229-7yoilsho	2868	26	collagen	collagen	NN
cord-006229-7yoilsho	2868	27	and	and	CC
cord-006229-7yoilsho	2868	28	pro	pro	JJ
cord-006229-7yoilsho	2868	29	-	-	JJ
cord-006229-7yoilsho	2868	30	hypertrophic	hypertrophic	JJ
cord-006229-7yoilsho	2868	31	cytokines	cytokine	NNS
cord-006229-7yoilsho	2868	32	influencing	influence	VBG
cord-006229-7yoilsho	2868	33	cardiomyocyte	cardiomyocyte	NNP
cord-006229-7yoilsho	2868	34	function	function	NN
cord-006229-7yoilsho	2868	35	and	and	CC
cord-006229-7yoilsho	2868	36	size	size	NN
cord-006229-7yoilsho	2868	37	.	.	.
cord-006229-7yoilsho	2869	1	It	-PRON-	PRP
cord-006229-7yoilsho	2869	2	was	be	VBD
cord-006229-7yoilsho	2869	3	shown	show	VBN
cord-006229-7yoilsho	2869	4	that	that	IN
cord-006229-7yoilsho	2869	5	β	β	NN
cord-006229-7yoilsho	2869	6	-	-	HYPH
cord-006229-7yoilsho	2869	7	adrenergic	adrenergic	JJ
cord-006229-7yoilsho	2869	8	stimulation	stimulation	NN
cord-006229-7yoilsho	2869	9	of	of	IN
cord-006229-7yoilsho	2869	10	CFs	cf	NNS
cord-006229-7yoilsho	2869	11	with	with	IN
cord-006229-7yoilsho	2869	12	isoproterenol	isoproterenol	NNP
cord-006229-7yoilsho	2869	13	leads	lead	VBZ
cord-006229-7yoilsho	2869	14	to	to	IN
cord-006229-7yoilsho	2869	15	Angiotensin	Angiotensin	NNP
cord-006229-7yoilsho	2869	16	II	II	NNP
cord-006229-7yoilsho	2869	17	(	(	-LRB-
cord-006229-7yoilsho	2869	18	AT	AT	NNP
cord-006229-7yoilsho	2869	19	-	-	HYPH
cord-006229-7yoilsho	2869	20	II	II	NNP
cord-006229-7yoilsho	2869	21	)	)	-RRB-
cord-006229-7yoilsho	2869	22	production	production	NN
cord-006229-7yoilsho	2869	23	and	and	CC
cord-006229-7yoilsho	2869	24	autocrine	autocrine	JJ
cord-006229-7yoilsho	2869	25	stimulation	stimulation	NN
cord-006229-7yoilsho	2869	26	of	of	IN
cord-006229-7yoilsho	2869	27	these	these	DT
cord-006229-7yoilsho	2869	28	cells	cell	NNS
cord-006229-7yoilsho	2869	29	(	(	-LRB-
cord-006229-7yoilsho	2869	30	Jaffre	Jaffre	NNP
cord-006229-7yoilsho	2869	31	et	et	NNP
cord-006229-7yoilsho	2869	32	al	al	NNP
cord-006229-7yoilsho	2869	33	,	,	,
cord-006229-7yoilsho	2869	34	2009	2009	CD
cord-006229-7yoilsho	2869	35	)	)	-RRB-
cord-006229-7yoilsho	2869	36	.	.	.
cord-006229-7yoilsho	2870	1	Activation	activation	NN
cord-006229-7yoilsho	2870	2	of	of	IN
cord-006229-7yoilsho	2870	3	Phoypholipase	Phoypholipase	NNP
cord-006229-7yoilsho	2870	4	C	C	NNP
cord-006229-7yoilsho	2870	5	triggered	trigger	VBN
cord-006229-7yoilsho	2870	6	by	by	IN
cord-006229-7yoilsho	2870	7	AT	AT	NNP
cord-006229-7yoilsho	2870	8	-	-	HYPH
cord-006229-7yoilsho	2870	9	II	II	NNP
cord-006229-7yoilsho	2870	10	leads	lead	VBZ
cord-006229-7yoilsho	2870	11	to	to	IN
cord-006229-7yoilsho	2870	12	formation	formation	NN
cord-006229-7yoilsho	2870	13	of	of	IN
cord-006229-7yoilsho	2870	14	Inositol	Inositol	NNP
cord-006229-7yoilsho	2870	15	trisphosphate	trisphosphate	JJ
cord-006229-7yoilsho	2870	16	(	(	-LRB-
cord-006229-7yoilsho	2870	17	IP	IP	NNP
cord-006229-7yoilsho	2870	18	3	3	CD
cord-006229-7yoilsho	2870	19	)	)	-RRB-
cord-006229-7yoilsho	2870	20	and	and	CC
cord-006229-7yoilsho	2870	21	subsequent	subsequent	JJ
cord-006229-7yoilsho	2870	22	release	release	NN
cord-006229-7yoilsho	2870	23	of	of	IN
cord-006229-7yoilsho	2870	24	calcium	calcium	NN
cord-006229-7yoilsho	2870	25	from	from	IN
cord-006229-7yoilsho	2870	26	intracellular	intracellular	JJ
cord-006229-7yoilsho	2870	27	stores	store	NNS
cord-006229-7yoilsho	2870	28	as	as	RB
cord-006229-7yoilsho	2870	29	well	well	RB
cord-006229-7yoilsho	2870	30	as	as	IN
cord-006229-7yoilsho	2870	31	calcium	calcium	NN
cord-006229-7yoilsho	2870	32	entry	entry	NN
cord-006229-7yoilsho	2870	33	across	across	IN
cord-006229-7yoilsho	2870	34	the	the	DT
cord-006229-7yoilsho	2870	35	cell	cell	NN
cord-006229-7yoilsho	2870	36	membrane	membrane	NN
cord-006229-7yoilsho	2870	37	.	.	.
cord-006229-7yoilsho	2871	1	The	the	DT
cord-006229-7yoilsho	2871	2	focus	focus	NN
cord-006229-7yoilsho	2871	3	of	of	IN
cord-006229-7yoilsho	2871	4	our	-PRON-	PRP$
cord-006229-7yoilsho	2871	5	research	research	NN
cord-006229-7yoilsho	2871	6	is	be	VBZ
cord-006229-7yoilsho	2871	7	the	the	DT
cord-006229-7yoilsho	2871	8	identification	identification	NN
cord-006229-7yoilsho	2871	9	of	of	IN
cord-006229-7yoilsho	2871	10	the	the	DT
cord-006229-7yoilsho	2871	11	plasmalemmal	plasmalemmal	NNP
cord-006229-7yoilsho	2871	12	channel	channel	NNP
cord-006229-7yoilsho	2871	13	proteins	protein	NNS
cord-006229-7yoilsho	2871	14	such	such	JJ
cord-006229-7yoilsho	2871	15	as	as	IN
cord-006229-7yoilsho	2871	16	TRPC	TRPC	NNP
cord-006229-7yoilsho	2871	17	channels	channel	NNS
cord-006229-7yoilsho	2871	18	mediating	mediate	VBG
cord-006229-7yoilsho	2871	19	this	this	DT
cord-006229-7yoilsho	2871	20	calcium	calcium	NN
cord-006229-7yoilsho	2871	21	entry	entry	NN
cord-006229-7yoilsho	2871	22	,	,	,
cord-006229-7yoilsho	2871	23	and	and	CC
cord-006229-7yoilsho	2871	24	whether	whether	IN
cord-006229-7yoilsho	2871	25	these	these	DT
cord-006229-7yoilsho	2871	26	calcium	calcium	NN
cord-006229-7yoilsho	2871	27	entry	entry	NN
cord-006229-7yoilsho	2871	28	pathways	pathway	NNS
cord-006229-7yoilsho	2871	29	in	in	IN
cord-006229-7yoilsho	2871	30	CFs	cf	NNS
cord-006229-7yoilsho	2871	31	contribute	contribute	VBP
cord-006229-7yoilsho	2871	32	to	to	IN
cord-006229-7yoilsho	2871	33	pathological	pathological	JJ
cord-006229-7yoilsho	2871	34	remodeling	remodeling	NN
cord-006229-7yoilsho	2871	35	.	.	.
cord-006229-7yoilsho	2872	1	To	to	IN
cord-006229-7yoilsho	2872	2	date	date	NN
cord-006229-7yoilsho	2872	3	the	the	DT
cord-006229-7yoilsho	2872	4	precise	precise	JJ
cord-006229-7yoilsho	2872	5	role	role	NN
cord-006229-7yoilsho	2872	6	of	of	IN
cord-006229-7yoilsho	2872	7	calcium	calcium	NN
cord-006229-7yoilsho	2872	8	entry	entry	NN
cord-006229-7yoilsho	2872	9	for	for	IN
cord-006229-7yoilsho	2872	10	these	these	DT
cord-006229-7yoilsho	2872	11	pathological	pathological	JJ
cord-006229-7yoilsho	2872	12	processes	process	NNS
cord-006229-7yoilsho	2872	13	is	be	VBZ
cord-006229-7yoilsho	2872	14	largely	largely	RB
cord-006229-7yoilsho	2872	15	unknown	unknown	JJ
cord-006229-7yoilsho	2872	16	.	.	.
cord-006229-7yoilsho	2873	1	TRPC	TRPC	NNP
cord-006229-7yoilsho	2873	2	channels	channel	NNS
cord-006229-7yoilsho	2873	3	are	be	VBP
cord-006229-7yoilsho	2873	4	candidates	candidate	NNS
cord-006229-7yoilsho	2873	5	for	for	IN
cord-006229-7yoilsho	2873	6	the	the	DT
cord-006229-7yoilsho	2873	7	analysis	analysis	NN
cord-006229-7yoilsho	2873	8	of	of	IN
cord-006229-7yoilsho	2873	9	calcium	calcium	NN
cord-006229-7yoilsho	2873	10	homeostasis	homeostasis	NN
cord-006229-7yoilsho	2873	11	in	in	IN
cord-006229-7yoilsho	2873	12	CF	CF	NNP
cord-006229-7yoilsho	2873	13	.	.	.
cord-006229-7yoilsho	2874	1	Recently	recently	RB
cord-006229-7yoilsho	2874	2	,	,	,
cord-006229-7yoilsho	2874	3	we	-PRON-	PRP
cord-006229-7yoilsho	2874	4	showed	show	VBD
cord-006229-7yoilsho	2874	5	that	that	IN
cord-006229-7yoilsho	2874	6	TRPC1	TRPC1	NNP
cord-006229-7yoilsho	2874	7	/	/	SYM
cord-006229-7yoilsho	2874	8	C4-deficient	c4-deficient	NN
cord-006229-7yoilsho	2874	9	mice	mouse	NNS
cord-006229-7yoilsho	2874	10	are	be	VBP
cord-006229-7yoilsho	2874	11	protected	protect	VBN
cord-006229-7yoilsho	2874	12	from	from	IN
cord-006229-7yoilsho	2874	13	maladaptive	maladaptive	JJ
cord-006229-7yoilsho	2874	14	cardiac	cardiac	JJ
cord-006229-7yoilsho	2874	15	remodeling	remodeling	NN
cord-006229-7yoilsho	2874	16	after	after	IN
cord-006229-7yoilsho	2874	17	neurohumoral	neurohumoral	JJ
cord-006229-7yoilsho	2874	18	stimulation	stimulation	NN
cord-006229-7yoilsho	2874	19	or	or	CC
cord-006229-7yoilsho	2874	20	pressure	pressure	NN
cord-006229-7yoilsho	2874	21	overload	overload	NN
cord-006229-7yoilsho	2874	22	,	,	,
cord-006229-7yoilsho	2874	23	respectively	respectively	RB
cord-006229-7yoilsho	2874	24	,	,	,
cord-006229-7yoilsho	2874	25	which	which	WDT
cord-006229-7yoilsho	2874	26	can	can	MD
cord-006229-7yoilsho	2874	27	be	be	VB
cord-006229-7yoilsho	2874	28	explained	explain	VBN
cord-006229-7yoilsho	2874	29	by	by	IN
cord-006229-7yoilsho	2874	30	a	a	DT
cord-006229-7yoilsho	2874	31	significant	significant	JJ
cord-006229-7yoilsho	2874	32	reduction	reduction	NN
cord-006229-7yoilsho	2874	33	of	of	IN
cord-006229-7yoilsho	2874	34	a	a	DT
cord-006229-7yoilsho	2874	35	Background	background	NN
cord-006229-7yoilsho	2875	1	Ca	ca	RB
cord-006229-7yoilsho	2875	2	2	2	CD
cord-006229-7yoilsho	2876	1	+	+	CC
cord-006229-7yoilsho	2877	1	-Entry	-Entry	NNP
cord-006229-7yoilsho	2878	1	(	(	-LRB-
cord-006229-7yoilsho	2878	2	BCGE	BCGE	NNP
cord-006229-7yoilsho	2878	3	)	)	-RRB-
cord-006229-7yoilsho	2878	4	pathway	pathway	NN
cord-006229-7yoilsho	2878	5	in	in	IN
cord-006229-7yoilsho	2878	6	cardiomyocytes	cardiomyocyte	NNS
cord-006229-7yoilsho	2879	1	;	;	:
cord-006229-7yoilsho	2879	2	this	this	DT
cord-006229-7yoilsho	2879	3	BGCE	BGCE	NNP
cord-006229-7yoilsho	2879	4	is	be	VBZ
cord-006229-7yoilsho	2879	5	enhanced	enhance	VBN
cord-006229-7yoilsho	2879	6	by	by	IN
cord-006229-7yoilsho	2879	7	stimulation	stimulation	NN
cord-006229-7yoilsho	2879	8	with	with	IN
cord-006229-7yoilsho	2879	9	agonists	agonist	NNS
cord-006229-7yoilsho	2879	10	such	such	JJ
cord-006229-7yoilsho	2879	11	as	as	IN
cord-006229-7yoilsho	2879	12	isoproterenol	isoproterenol	NNP
cord-006229-7yoilsho	2879	13	or	or	CC
cord-006229-7yoilsho	2879	14	angiotensin	angiotensin	NN
cord-006229-7yoilsho	2879	15	II	II	NNP
cord-006229-7yoilsho	2879	16	and	and	CC
cord-006229-7yoilsho	2879	17	it	-PRON-	PRP
cord-006229-7yoilsho	2879	18	critically	critically	RB
cord-006229-7yoilsho	2879	19	depends	depend	VBZ
cord-006229-7yoilsho	2879	20	on	on	IN
cord-006229-7yoilsho	2879	21	TRPC1	trpc1	NN
cord-006229-7yoilsho	2879	22	and	and	CC
cord-006229-7yoilsho	2879	23	TRPC4	TRPC4	NNP
cord-006229-7yoilsho	2880	1	(	(	-LRB-
cord-006229-7yoilsho	2880	2	Camacho	Camacho	NNP
cord-006229-7yoilsho	2880	3	Londoño	Londoño	NNP
cord-006229-7yoilsho	2880	4	et	et	NNP
cord-006229-7yoilsho	2880	5	al	al	NNP
cord-006229-7yoilsho	2880	6	.	.	NNP
cord-006229-7yoilsho	2880	7	,	,	,
cord-006229-7yoilsho	2880	8	2015	2015	CD
cord-006229-7yoilsho	2880	9	)	)	-RRB-
cord-006229-7yoilsho	2880	10	.	.	.
cord-006229-7yoilsho	2881	1	Nevertheless	nevertheless	RB
cord-006229-7yoilsho	2881	2	,	,	,
cord-006229-7yoilsho	2881	3	the	the	DT
cord-006229-7yoilsho	2881	4	role	role	NN
cord-006229-7yoilsho	2881	5	of	of	IN
cord-006229-7yoilsho	2881	6	TRPC1	TRPC1	NNP
cord-006229-7yoilsho	2881	7	/	/	SYM
cord-006229-7yoilsho	2881	8	C4	c4	NN
cord-006229-7yoilsho	2881	9	for	for	IN
cord-006229-7yoilsho	2881	10	calcium	calcium	NN
cord-006229-7yoilsho	2881	11	homeostasis	homeostasis	NN
cord-006229-7yoilsho	2881	12	in	in	IN
cord-006229-7yoilsho	2881	13	CFs	CFs	NNP
cord-006229-7yoilsho	2881	14	has	have	VBZ
cord-006229-7yoilsho	2881	15	not	not	RB
cord-006229-7yoilsho	2881	16	been	be	VBN
cord-006229-7yoilsho	2881	17	analyzed	analyze	VBN
cord-006229-7yoilsho	2881	18	so	so	RB
cord-006229-7yoilsho	2881	19	far	far	RB
cord-006229-7yoilsho	2881	20	.	.	.
cord-006229-7yoilsho	2882	1	We	-PRON-	PRP
cord-006229-7yoilsho	2882	2	established	establish	VBD
cord-006229-7yoilsho	2882	3	an	an	DT
cord-006229-7yoilsho	2882	4	in	in	FW
cord-006229-7yoilsho	2882	5	vitro	vitro	FW
cord-006229-7yoilsho	2882	6	model	model	NN
cord-006229-7yoilsho	2882	7	that	that	WDT
cord-006229-7yoilsho	2882	8	allows	allow	VBZ
cord-006229-7yoilsho	2882	9	the	the	DT
cord-006229-7yoilsho	2882	10	analysis	analysis	NN
cord-006229-7yoilsho	2882	11	of	of	IN
cord-006229-7yoilsho	2882	12	calcium	calcium	NN
cord-006229-7yoilsho	2882	13	release	release	NN
cord-006229-7yoilsho	2882	14	and	and	CC
cord-006229-7yoilsho	2882	15	entry	entry	NN
cord-006229-7yoilsho	2882	16	triggered	trigger	VBN
cord-006229-7yoilsho	2882	17	by	by	IN
cord-006229-7yoilsho	2882	18	several	several	JJ
cord-006229-7yoilsho	2882	19	(	(	-LRB-
cord-006229-7yoilsho	2882	20	patho)physiological	patho)physiological	NNP
cord-006229-7yoilsho	2882	21	agonists	agonist	NNS
cord-006229-7yoilsho	2882	22	in	in	IN
cord-006229-7yoilsho	2882	23	cultured	cultured	JJ
cord-006229-7yoilsho	2882	24	primary	primary	JJ
cord-006229-7yoilsho	2882	25	adult	adult	NN
cord-006229-7yoilsho	2882	26	CFs	cf	NNS
cord-006229-7yoilsho	2882	27	from	from	IN
cord-006229-7yoilsho	2882	28	mice	mouse	NNS
cord-006229-7yoilsho	2882	29	.	.	.
cord-006229-7yoilsho	2883	1	CFs	cf	NNS
cord-006229-7yoilsho	2883	2	were	be	VBD
cord-006229-7yoilsho	2883	3	isolated	isolate	VBN
cord-006229-7yoilsho	2883	4	using	use	VBG
cord-006229-7yoilsho	2883	5	Langendorff	Langendorff	NNP
cord-006229-7yoilsho	2883	6	-	-	HYPH
cord-006229-7yoilsho	2883	7	perfusion	perfusion	NN
cord-006229-7yoilsho	2883	8	and	and	CC
cord-006229-7yoilsho	2883	9	were	be	VBD
cord-006229-7yoilsho	2883	10	cultured	culture	VBN
cord-006229-7yoilsho	2883	11	for	for	IN
cord-006229-7yoilsho	2883	12	maximal	maximal	JJ
cord-006229-7yoilsho	2883	13	6	6	CD
cord-006229-7yoilsho	2883	14	days	day	NNS
cord-006229-7yoilsho	2883	15	.	.	.
cord-006229-7yoilsho	2884	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	2884	2	results	result	NNS
cord-006229-7yoilsho	2884	3	show	show	VBP
cord-006229-7yoilsho	2884	4	that	that	IN
cord-006229-7yoilsho	2884	5	there	there	EX
cord-006229-7yoilsho	2884	6	is	be	VBZ
cord-006229-7yoilsho	2884	7	no	no	DT
cord-006229-7yoilsho	2884	8	difference	difference	NN
cord-006229-7yoilsho	2884	9	in	in	IN
cord-006229-7yoilsho	2884	10	100	100	CD
cord-006229-7yoilsho	2884	11	nM	nm	CD
cord-006229-7yoilsho	2884	12	AT	AT	NNP
cord-006229-7yoilsho	2884	13	-	-	HYPH
cord-006229-7yoilsho	2884	14	II	II	NNP
cord-006229-7yoilsho	2884	15	induced	induce	VBN
cord-006229-7yoilsho	2885	1	Ca	ca	NN
cord-006229-7yoilsho	2885	2	2	2	CD
cord-006229-7yoilsho	2885	3	+	+	SYM
cord-006229-7yoilsho	2885	4	-release	-release	.
cord-006229-7yoilsho	2886	1	or	or	CC
cord-006229-7yoilsho	2886	2	Ca	Ca	NNP
cord-006229-7yoilsho	2886	3	2	2	CD
cord-006229-7yoilsho	2886	4	+	+	CD
cord-006229-7yoilsho	2886	5	-entry	-entry	.
cord-006229-7yoilsho	2887	1	in	in	IN
cord-006229-7yoilsho	2887	2	TRPC1	TRPC1	NNP
cord-006229-7yoilsho	2887	3	/	/	SYM
cord-006229-7yoilsho	2887	4	C4-deficient	c4-deficient	CC
cord-006229-7yoilsho	2887	5	CF	CF	NNP
cord-006229-7yoilsho	2888	1	compared	compare	VBN
cord-006229-7yoilsho	2888	2	to	to	IN
cord-006229-7yoilsho	2888	3	WT	WT	NNP
cord-006229-7yoilsho	2888	4	.	.	.
cord-006229-7yoilsho	2889	1	To	to	TO
cord-006229-7yoilsho	2889	2	evaluate	evaluate	VB
cord-006229-7yoilsho	2889	3	whether	whether	IN
cord-006229-7yoilsho	2889	4	the	the	DT
cord-006229-7yoilsho	2889	5	lack	lack	NN
cord-006229-7yoilsho	2889	6	of	of	IN
cord-006229-7yoilsho	2889	7	TRPC1	TRPC1	NNP
cord-006229-7yoilsho	2889	8	/	/	SYM
cord-006229-7yoilsho	2889	9	C4	C4	NNP
cord-006229-7yoilsho	2889	10	can	can	MD
cord-006229-7yoilsho	2889	11	be	be	VB
cord-006229-7yoilsho	2889	12	compensated	compensate	VBN
cord-006229-7yoilsho	2889	13	by	by	IN
cord-006229-7yoilsho	2889	14	other	other	JJ
cord-006229-7yoilsho	2889	15	TRPC	TRPC	NNP
cord-006229-7yoilsho	2889	16	channels	channel	NNS
cord-006229-7yoilsho	2889	17	we	-PRON-	PRP
cord-006229-7yoilsho	2889	18	currently	currently	RB
cord-006229-7yoilsho	2889	19	analyze	analyze	VBP
cord-006229-7yoilsho	2889	20	CFs	cf	NNS
cord-006229-7yoilsho	2889	21	from	from	IN
cord-006229-7yoilsho	2889	22	TRPC	TRPC	NNP
cord-006229-7yoilsho	2889	23	Hepta	Hepta	NNP
cord-006229-7yoilsho	2889	24	KO	KO	NNP
cord-006229-7yoilsho	2889	25	mice	mouse	NNS
cord-006229-7yoilsho	2889	26	lacking	lack	VBG
cord-006229-7yoilsho	2889	27	all	all	DT
cord-006229-7yoilsho	2889	28	seven	seven	CD
cord-006229-7yoilsho	2889	29	TRPC	TRPC	NNP
cord-006229-7yoilsho	2889	30	channel	channel	NN
cord-006229-7yoilsho	2889	31	proteins	protein	NNS
cord-006229-7yoilsho	2889	32	concerning	concern	VBG
cord-006229-7yoilsho	2889	33	AT	AT	NNP
cord-006229-7yoilsho	2889	34	-	-	HYPH
cord-006229-7yoilsho	2889	35	II	II	NNP
cord-006229-7yoilsho	2889	36	induced	induce	VBN
cord-006229-7yoilsho	2890	1	Ca	ca	NN
cord-006229-7yoilsho	2890	2	2	2	CD
cord-006229-7yoilsho	2890	3	+	+	CD
cord-006229-7yoilsho	2891	1	-release	-release	:
cord-006229-7yoilsho	2892	1	and	and	CC
cord-006229-7yoilsho	2892	2	Ca	Ca	NNP
cord-006229-7yoilsho	2892	3	2	2	CD
cord-006229-7yoilsho	2892	4	+	+	.
cord-006229-7yoilsho	2893	1	-entry	-entry	.
cord-006229-7yoilsho	2894	1	and	and	CC
cord-006229-7yoilsho	2894	2	we	-PRON-	PRP
cord-006229-7yoilsho	2894	3	will	will	MD
cord-006229-7yoilsho	2894	4	also	also	RB
cord-006229-7yoilsho	2894	5	analyze	analyze	VB
cord-006229-7yoilsho	2894	6	the	the	DT
cord-006229-7yoilsho	2894	7	influence	influence	NN
cord-006229-7yoilsho	2894	8	of	of	IN
cord-006229-7yoilsho	2894	9	other	other	JJ
cord-006229-7yoilsho	2894	10	agonists	agonist	NNS
cord-006229-7yoilsho	2894	11	on	on	IN
cord-006229-7yoilsho	2894	12	CFs	cf	NNS
cord-006229-7yoilsho	2894	13	which	which	WDT
cord-006229-7yoilsho	2894	14	are	be	VBP
cord-006229-7yoilsho	2894	15	known	know	VBN
cord-006229-7yoilsho	2894	16	to	to	TO
cord-006229-7yoilsho	2894	17	evoke	evoke	VB
cord-006229-7yoilsho	2894	18	a	a	DT
cord-006229-7yoilsho	2894	19	longer	long	RBR
cord-006229-7yoilsho	2894	20	lasting	lasting	JJ
cord-006229-7yoilsho	2894	21	rise	rise	NN
cord-006229-7yoilsho	2894	22	in	in	IN
cord-006229-7yoilsho	2894	23	the	the	DT
cord-006229-7yoilsho	2894	24	[	[	-LRB-
cord-006229-7yoilsho	2894	25	Ca	Ca	NNP
cord-006229-7yoilsho	2894	26	2	2	CD
cord-006229-7yoilsho	2895	1	+	+	LS
cord-006229-7yoilsho	2895	2	]	]	-RRB-
cord-006229-7yoilsho	2895	3	i	i	PRP
cord-006229-7yoilsho	2895	4	like	like	VBP
cord-006229-7yoilsho	2895	5	isoproterenol	isoproterenol	NNP
cord-006229-7yoilsho	2895	6	,	,	,
cord-006229-7yoilsho	2895	7	5-HT	5-ht	CD
cord-006229-7yoilsho	2895	8	,	,	,
cord-006229-7yoilsho	2895	9	thrombin	thrombin	NN
cord-006229-7yoilsho	2895	10	and	and	CC
cord-006229-7yoilsho	2895	11	Endothelin-1	Endothelin-1	NNP
cord-006229-7yoilsho	2895	12	.	.	.
cord-006229-7yoilsho	2896	1	Cardiovascular	cardiovascular	JJ
cord-006229-7yoilsho	2896	2	and	and	CC
cord-006229-7yoilsho	2896	3	metabolic	metabolic	JJ
cord-006229-7yoilsho	2896	4	diseases	disease	NNS
cord-006229-7yoilsho	2896	5	are	be	VBP
cord-006229-7yoilsho	2896	6	currently	currently	RB
cord-006229-7yoilsho	2896	7	the	the	DT
cord-006229-7yoilsho	2896	8	primary	primary	JJ
cord-006229-7yoilsho	2896	9	cause	cause	NN
cord-006229-7yoilsho	2896	10	of	of	IN
cord-006229-7yoilsho	2896	11	morbidity	morbidity	NN
cord-006229-7yoilsho	2896	12	and	and	CC
cord-006229-7yoilsho	2896	13	mortality	mortality	NN
cord-006229-7yoilsho	2896	14	in	in	IN
cord-006229-7yoilsho	2896	15	the	the	DT
cord-006229-7yoilsho	2896	16	western	western	JJ
cord-006229-7yoilsho	2896	17	world	world	NN
cord-006229-7yoilsho	2896	18	and	and	CC
cord-006229-7yoilsho	2896	19	are	be	VBP
cord-006229-7yoilsho	2896	20	spreading	spread	VBG
cord-006229-7yoilsho	2896	21	to	to	IN
cord-006229-7yoilsho	2896	22	the	the	DT
cord-006229-7yoilsho	2896	23	rest	rest	NN
cord-006229-7yoilsho	2896	24	of	of	IN
cord-006229-7yoilsho	2896	25	the	the	DT
cord-006229-7yoilsho	2896	26	world	world	NN
cord-006229-7yoilsho	2896	27	following	follow	VBG
cord-006229-7yoilsho	2896	28	globalization	globalization	NN
cord-006229-7yoilsho	2896	29	.	.	.
cord-006229-7yoilsho	2897	1	Adipose	adipose	JJ
cord-006229-7yoilsho	2897	2	tissue	tissue	NN
cord-006229-7yoilsho	2897	3	,	,	,
cord-006229-7yoilsho	2897	4	in	in	IN
cord-006229-7yoilsho	2897	5	particular	particular	JJ
cord-006229-7yoilsho	2897	6	perivascular	perivascular	JJ
cord-006229-7yoilsho	2897	7	adipose	adipose	JJ
cord-006229-7yoilsho	2897	8	tissue	tissue	NN
cord-006229-7yoilsho	2897	9	(	(	-LRB-
cord-006229-7yoilsho	2897	10	PVAT	PVAT	NNP
cord-006229-7yoilsho	2897	11	)	)	-RRB-
cord-006229-7yoilsho	2897	12	is	be	VBZ
cord-006229-7yoilsho	2897	13	recognized	recognize	VBN
cord-006229-7yoilsho	2897	14	as	as	IN
cord-006229-7yoilsho	2897	15	an	an	DT
cord-006229-7yoilsho	2897	16	important	important	JJ
cord-006229-7yoilsho	2897	17	player	player	NN
cord-006229-7yoilsho	2897	18	in	in	IN
cord-006229-7yoilsho	2897	19	the	the	DT
cord-006229-7yoilsho	2897	20	development	development	NN
cord-006229-7yoilsho	2897	21	of	of	IN
cord-006229-7yoilsho	2897	22	these	these	DT
cord-006229-7yoilsho	2897	23	diseases	disease	NNS
cord-006229-7yoilsho	2897	24	.	.	.
cord-006229-7yoilsho	2898	1	The	the	DT
cord-006229-7yoilsho	2898	2	release	release	NN
cord-006229-7yoilsho	2898	3	of	of	IN
cord-006229-7yoilsho	2898	4	relaxing	relax	VBG
cord-006229-7yoilsho	2898	5	factor(s	factor(s	NNP
cord-006229-7yoilsho	2898	6	)	)	-RRB-
cord-006229-7yoilsho	2898	7	from	from	IN
cord-006229-7yoilsho	2898	8	the	the	DT
cord-006229-7yoilsho	2898	9	PVAT	PVAT	NNP
cord-006229-7yoilsho	2898	10	has	have	VBZ
cord-006229-7yoilsho	2898	11	been	be	VBN
cord-006229-7yoilsho	2898	12	a	a	DT
cord-006229-7yoilsho	2898	13	matter	matter	NN
cord-006229-7yoilsho	2898	14	of	of	IN
cord-006229-7yoilsho	2898	15	interesting	interesting	JJ
cord-006229-7yoilsho	2898	16	and	and	CC
cord-006229-7yoilsho	2898	17	highly	highly	RB
cord-006229-7yoilsho	2898	18	spirited	spirited	JJ
cord-006229-7yoilsho	2898	19	debates	debate	NNS
cord-006229-7yoilsho	2898	20	about	about	IN
cord-006229-7yoilsho	2898	21	its	-PRON-	PRP$
cord-006229-7yoilsho	2898	22	nature	nature	NN
cord-006229-7yoilsho	2898	23	,	,	,
cord-006229-7yoilsho	2898	24	the	the	DT
cord-006229-7yoilsho	2898	25	channels	channel	NNS
cord-006229-7yoilsho	2898	26	that	that	WDT
cord-006229-7yoilsho	2898	27	govern	govern	VBP
cord-006229-7yoilsho	2898	28	its	-PRON-	PRP$
cord-006229-7yoilsho	2898	29	activities	activity	NNS
cord-006229-7yoilsho	2898	30	and	and	CC
cord-006229-7yoilsho	2898	31	its	-PRON-	PRP$
cord-006229-7yoilsho	2898	32	role	role	NN
cord-006229-7yoilsho	2898	33	in	in	IN
cord-006229-7yoilsho	2898	34	vascular	vascular	JJ
cord-006229-7yoilsho	2898	35	dysfunction	dysfunction	NN
cord-006229-7yoilsho	2898	36	.	.	.
cord-006229-7yoilsho	2899	1	Data	datum	NNS
cord-006229-7yoilsho	2899	2	from	from	IN
cord-006229-7yoilsho	2899	3	our	-PRON-	PRP$
cord-006229-7yoilsho	2899	4	laboratory	laboratory	NN
cord-006229-7yoilsho	2899	5	indicate	indicate	VBP
cord-006229-7yoilsho	2899	6	that	that	IN
cord-006229-7yoilsho	2899	7	Adipose	Adipose	NNP
cord-006229-7yoilsho	2899	8	-	-	HYPH
cord-006229-7yoilsho	2899	9	Derived	derive	VBN
cord-006229-7yoilsho	2899	10	Relaxing	Relaxing	NNP
cord-006229-7yoilsho	2899	11	Factor	factor	NN
cord-006229-7yoilsho	2899	12	(	(	-LRB-
cord-006229-7yoilsho	2899	13	ADRF	ADRF	NNP
cord-006229-7yoilsho	2899	14	)	)	-RRB-
cord-006229-7yoilsho	2899	15	is	be	VBZ
cord-006229-7yoilsho	2899	16	an	an	DT
cord-006229-7yoilsho	2899	17	important	important	JJ
cord-006229-7yoilsho	2899	18	player	player	NN
cord-006229-7yoilsho	2899	19	,	,	,
cord-006229-7yoilsho	2899	20	however	however	RB
cord-006229-7yoilsho	2899	21	the	the	DT
cord-006229-7yoilsho	2899	22	potential	potential	JJ
cord-006229-7yoilsho	2899	23	channels	channel	NNS
cord-006229-7yoilsho	2899	24	necessary	necessary	JJ
cord-006229-7yoilsho	2899	25	for	for	IN
cord-006229-7yoilsho	2899	26	its	-PRON-	PRP$
cord-006229-7yoilsho	2899	27	downstream	downstream	JJ
cord-006229-7yoilsho	2899	28	activities	activity	NNS
cord-006229-7yoilsho	2899	29	are	be	VBP
cord-006229-7yoilsho	2899	30	still	still	RB
cord-006229-7yoilsho	2899	31	under	under	IN
cord-006229-7yoilsho	2899	32	study	study	NN
cord-006229-7yoilsho	2899	33	.	.	.
cord-006229-7yoilsho	2900	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	2900	2	recent	recent	JJ
cord-006229-7yoilsho	2900	3	research	research	NN
cord-006229-7yoilsho	2900	4	primarily	primarily	RB
cord-006229-7yoilsho	2900	5	focuses	focus	VBZ
cord-006229-7yoilsho	2900	6	on	on	IN
cord-006229-7yoilsho	2900	7	Kv7.1	Kv7.1	NNP
cord-006229-7yoilsho	2900	8	channels	channel	NNS
cord-006229-7yoilsho	2900	9	,	,	,
cord-006229-7yoilsho	2900	10	which	which	WDT
cord-006229-7yoilsho	2900	11	are	be	VBP
cord-006229-7yoilsho	2900	12	known	know	VBN
cord-006229-7yoilsho	2900	13	to	to	TO
cord-006229-7yoilsho	2900	14	be	be	VB
cord-006229-7yoilsho	2900	15	expressed	express	VBN
cord-006229-7yoilsho	2900	16	in	in	IN
cord-006229-7yoilsho	2900	17	vascular	vascular	JJ
cord-006229-7yoilsho	2900	18	smooth	smooth	JJ
cord-006229-7yoilsho	2900	19	muscle	muscle	NN
cord-006229-7yoilsho	2900	20	cells	cell	NNS
cord-006229-7yoilsho	2900	21	.	.	.
cord-006229-7yoilsho	2901	1	K	K	NNP
cord-006229-7yoilsho	2901	2	V	v	NN
cord-006229-7yoilsho	2901	3	7.1	7.1	CD
cord-006229-7yoilsho	2901	4	voltage	voltage	NN
cord-006229-7yoilsho	2901	5	-	-	HYPH
cord-006229-7yoilsho	2901	6	gated	gate	VBN
cord-006229-7yoilsho	2901	7	potassium	potassium	NN
cord-006229-7yoilsho	2901	8	channels	channel	NNS
cord-006229-7yoilsho	2901	9	are	be	VBP
cord-006229-7yoilsho	2901	10	expressed	express	VBN
cord-006229-7yoilsho	2901	11	in	in	IN
cord-006229-7yoilsho	2901	12	vascular	vascular	JJ
cord-006229-7yoilsho	2901	13	smooth	smooth	JJ
cord-006229-7yoilsho	2901	14	muscle	muscle	NN
cord-006229-7yoilsho	2901	15	cells	cell	NNS
cord-006229-7yoilsho	2901	16	(	(	-LRB-
cord-006229-7yoilsho	2901	17	VSMC	VSMC	NNP
cord-006229-7yoilsho	2901	18	)	)	-RRB-
cord-006229-7yoilsho	2901	19	of	of	IN
cord-006229-7yoilsho	2901	20	diverse	diverse	JJ
cord-006229-7yoilsho	2901	21	arteries	artery	NNS
cord-006229-7yoilsho	2901	22	,	,	,
cord-006229-7yoilsho	2901	23	including	include	VBG
cord-006229-7yoilsho	2901	24	mesenteric	mesenteric	JJ
cord-006229-7yoilsho	2901	25	arteries	artery	NNS
cord-006229-7yoilsho	2901	26	.	.	.
cord-006229-7yoilsho	2902	1	Based	base	VBN
cord-006229-7yoilsho	2902	2	on	on	IN
cord-006229-7yoilsho	2902	3	pharmacological	pharmacological	JJ
cord-006229-7yoilsho	2902	4	evidence	evidence	NN
cord-006229-7yoilsho	2902	5	using	use	VBG
cord-006229-7yoilsho	2902	6	R	R	NNP
cord-006229-7yoilsho	2902	7	-	-	HYPH
cord-006229-7yoilsho	2902	8	L3	L3	NNP
cord-006229-7yoilsho	2902	9	(	(	-LRB-
cord-006229-7yoilsho	2902	10	K	K	NNP
cord-006229-7yoilsho	2902	11	V	v	NN
cord-006229-7yoilsho	2902	12	7.1	7.1	CD
cord-006229-7yoilsho	2902	13	opener	opener	NN
cord-006229-7yoilsho	2902	14	)	)	-RRB-
cord-006229-7yoilsho	2902	15	,	,	,
cord-006229-7yoilsho	2902	16	HMR1556	HMR1556	NNP
cord-006229-7yoilsho	2902	17	,	,	,
cord-006229-7yoilsho	2902	18	chromanol-293B	chromanol-293B	NNP
cord-006229-7yoilsho	2902	19	(	(	-LRB-
cord-006229-7yoilsho	2902	20	K	K	NNP
cord-006229-7yoilsho	2902	21	V	V	NNP
cord-006229-7yoilsho	2902	22	7.1	7.1	CD
cord-006229-7yoilsho	2902	23	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	2902	24	)	)	-RRB-
cord-006229-7yoilsho	2902	25	,	,	,
cord-006229-7yoilsho	2902	26	these	these	DT
cord-006229-7yoilsho	2902	27	channels	channel	NNS
cord-006229-7yoilsho	2902	28	have	have	VBP
cord-006229-7yoilsho	2902	29	been	be	VBN
cord-006229-7yoilsho	2902	30	suggested	suggest	VBN
cord-006229-7yoilsho	2902	31	to	to	TO
cord-006229-7yoilsho	2902	32	be	be	VB
cord-006229-7yoilsho	2902	33	involved	involve	VBN
cord-006229-7yoilsho	2902	34	in	in	IN
cord-006229-7yoilsho	2902	35	the	the	DT
cord-006229-7yoilsho	2902	36	regulation	regulation	NN
cord-006229-7yoilsho	2902	37	of	of	IN
cord-006229-7yoilsho	2902	38	vascular	vascular	JJ
cord-006229-7yoilsho	2902	39	tone	tone	NN
cord-006229-7yoilsho	2902	40	.	.	.
cord-006229-7yoilsho	2903	1	However	however	RB
cord-006229-7yoilsho	2903	2	,	,	,
cord-006229-7yoilsho	2903	3	the	the	DT
cord-006229-7yoilsho	2903	4	specificity	specificity	NN
cord-006229-7yoilsho	2903	5	of	of	IN
cord-006229-7yoilsho	2903	6	these	these	DT
cord-006229-7yoilsho	2903	7	drugs	drug	NNS
cord-006229-7yoilsho	2903	8	in	in	IN
cord-006229-7yoilsho	2903	9	vivo	vivo	NNP
cord-006229-7yoilsho	2903	10	is	be	VBZ
cord-006229-7yoilsho	2903	11	uncertain	uncertain	JJ
cord-006229-7yoilsho	2903	12	.	.	.
cord-006229-7yoilsho	2904	1	We	-PRON-	PRP
cord-006229-7yoilsho	2904	2	used	use	VBD
cord-006229-7yoilsho	2904	3	Kcnq1-/-mice	Kcnq1-/-mice	NNS
cord-006229-7yoilsho	2904	4	to	to	TO
cord-006229-7yoilsho	2904	5	determine	determine	VB
cord-006229-7yoilsho	2904	6	whether	whether	IN
cord-006229-7yoilsho	2904	7	K	K	NNP
cord-006229-7yoilsho	2904	8	V	V	NNP
cord-006229-7yoilsho	2904	9	7.1	7.1	CD
cord-006229-7yoilsho	2904	10	plays	play	VBZ
cord-006229-7yoilsho	2904	11	a	a	DT
cord-006229-7yoilsho	2904	12	role	role	NN
cord-006229-7yoilsho	2904	13	in	in	IN
cord-006229-7yoilsho	2904	14	the	the	DT
cord-006229-7yoilsho	2904	15	regulation	regulation	NN
cord-006229-7yoilsho	2904	16	of	of	IN
cord-006229-7yoilsho	2904	17	arterial	arterial	JJ
cord-006229-7yoilsho	2904	18	tone	tone	NN
cord-006229-7yoilsho	2904	19	.	.	.
cord-006229-7yoilsho	2905	1	We	-PRON-	PRP
cord-006229-7yoilsho	2905	2	found	find	VBD
cord-006229-7yoilsho	2905	3	that	that	IN
cord-006229-7yoilsho	2905	4	R	R	NNP
cord-006229-7yoilsho	2905	5	-	-	HYPH
cord-006229-7yoilsho	2905	6	L3	L3	NNP
cord-006229-7yoilsho	2905	7	produces	produce	VBZ
cord-006229-7yoilsho	2905	8	similar	similar	JJ
cord-006229-7yoilsho	2905	9	concentration	concentration	NN
cord-006229-7yoilsho	2905	10	-	-	HYPH
cord-006229-7yoilsho	2905	11	dependent	dependent	JJ
cord-006229-7yoilsho	2905	12	relaxations	relaxation	NNS
cord-006229-7yoilsho	2905	13	(	(	-LRB-
cord-006229-7yoilsho	2905	14	EC	EC	NNP
cord-006229-7yoilsho	2905	15	50	50	CD
cord-006229-7yoilsho	2905	16	~1,4	~1,4	NFP
cord-006229-7yoilsho	2905	17	µM	µm	NN
cord-006229-7yoilsho	2905	18	)	)	-RRB-
cord-006229-7yoilsho	2905	19	of	of	IN
cord-006229-7yoilsho	2905	20	wild	wild	JJ
cord-006229-7yoilsho	2905	21	-	-	HYPH
cord-006229-7yoilsho	2905	22	type	type	NN
cord-006229-7yoilsho	2905	23	(	(	-LRB-
cord-006229-7yoilsho	2905	24	Kcnq1+/+	kcnq1+/+	NN
cord-006229-7yoilsho	2905	25	)	)	-RRB-
cord-006229-7yoilsho	2905	26	and	and	CC
cord-006229-7yoilsho	2905	27	Kcnq1-/-arteries	kcnq1-/-arterie	VBZ
cord-006229-7yoilsho	2905	28	pre	pre	VB
cord-006229-7yoilsho	2905	29	-	-	VBN
cord-006229-7yoilsho	2905	30	contracted	contract	VBN
cord-006229-7yoilsho	2905	31	with	with	IN
cord-006229-7yoilsho	2905	32	either	either	CC
cord-006229-7yoilsho	2905	33	phenylephrine	phenylephrine	NN
cord-006229-7yoilsho	2905	34	or	or	CC
cord-006229-7yoilsho	2905	35	60	60	CD
cord-006229-7yoilsho	2905	36	mM	mm	CD
cord-006229-7yoilsho	2905	37	KCl	KCl	NNS
cord-006229-7yoilsho	2905	38	.	.	.
cord-006229-7yoilsho	2906	1	This	this	DT
cord-006229-7yoilsho	2906	2	relaxation	relaxation	NN
cord-006229-7yoilsho	2906	3	was	be	VBD
cord-006229-7yoilsho	2906	4	not	not	RB
cord-006229-7yoilsho	2906	5	affected	affect	VBN
cord-006229-7yoilsho	2906	6	by	by	IN
cord-006229-7yoilsho	2906	7	10	10	CD
cord-006229-7yoilsho	2906	8	µM	µm	NN
cord-006229-7yoilsho	2906	9	chromanol-293B	chromanol-293B	NNP
cord-006229-7yoilsho	2906	10	,	,	,
cord-006229-7yoilsho	2906	11	10	10	CD
cord-006229-7yoilsho	2906	12	µM	µm	CD
cord-006229-7yoilsho	2906	13	HMR1556	HMR1556	NNP
cord-006229-7yoilsho	2906	14	or	or	CC
cord-006229-7yoilsho	2906	15	30	30	CD
cord-006229-7yoilsho	2906	16	µM	µm	XX
cord-006229-7yoilsho	2907	1	XE991	xe991	NN
cord-006229-7yoilsho	2908	1	(	(	-LRB-
cord-006229-7yoilsho	2908	2	pan	pan	JJ
cord-006229-7yoilsho	2908	3	-	-	HYPH
cord-006229-7yoilsho	2908	4	K	K	NNP
cord-006229-7yoilsho	2908	5	V	v	NN
cord-006229-7yoilsho	2908	6	7	7	CD
cord-006229-7yoilsho	2908	7	blocker	blocker	NN
cord-006229-7yoilsho	2908	8	)	)	-RRB-
cord-006229-7yoilsho	2908	9	.	.	.
cord-006229-7yoilsho	2909	1	The	the	DT
cord-006229-7yoilsho	2909	2	anti	anti	JJ
cord-006229-7yoilsho	2909	3	-	-	JJ
cord-006229-7yoilsho	2909	4	contractile	contractile	JJ
cord-006229-7yoilsho	2909	5	effects	effect	NNS
cord-006229-7yoilsho	2909	6	of	of	IN
cord-006229-7yoilsho	2909	7	PVAT	PVAT	NNS
cord-006229-7yoilsho	2909	8	were	be	VBD
cord-006229-7yoilsho	2909	9	normal	normal	JJ
cord-006229-7yoilsho	2909	10	in	in	IN
cord-006229-7yoilsho	2909	11	Kcnq1-/-arteries	kcnq1-/-arterie	NNS
cord-006229-7yoilsho	2909	12	.	.	.
cord-006229-7yoilsho	2910	1	Chromanol-293B	Chromanol-293B	NNP
cord-006229-7yoilsho	2910	2	and	and	CC
cord-006229-7yoilsho	2910	3	HMR1556	HMR1556	NNP
cord-006229-7yoilsho	2910	4	did	do	VBD
cord-006229-7yoilsho	2910	5	not	not	RB
cord-006229-7yoilsho	2910	6	affect	affect	VB
cord-006229-7yoilsho	2910	7	the	the	DT
cord-006229-7yoilsho	2910	8	anti	anti	JJ
cord-006229-7yoilsho	2910	9	-	-	JJ
cord-006229-7yoilsho	2910	10	contractile	contractile	JJ
cord-006229-7yoilsho	2910	11	effects	effect	NNS
cord-006229-7yoilsho	2910	12	of	of	IN
cord-006229-7yoilsho	2910	13	perivascular	perivascular	JJ
cord-006229-7yoilsho	2910	14	adipose	adipose	JJ
cord-006229-7yoilsho	2910	15	tissue	tissue	NN
cord-006229-7yoilsho	2910	16	(	(	-LRB-
cord-006229-7yoilsho	2910	17	PVAT	PVAT	NNP
cord-006229-7yoilsho	2910	18	)	)	-RRB-
cord-006229-7yoilsho	2910	19	.	.	.
cord-006229-7yoilsho	2911	1	Isolated	isolated	JJ
cord-006229-7yoilsho	2911	2	VSMCs	vsmc	NNS
cord-006229-7yoilsho	2911	3	from	from	IN
cord-006229-7yoilsho	2911	4	Kcnq1-/-mice	Kcnq1-/-mice	NNP
cord-006229-7yoilsho	2911	5	exhibited	exhibit	VBD
cord-006229-7yoilsho	2911	6	normal	normal	JJ
cord-006229-7yoilsho	2911	7	peak	peak	NN
cord-006229-7yoilsho	2911	8	K	k	NN
cord-006229-7yoilsho	2911	9	v	v	IN
cord-006229-7yoilsho	2911	10	currents	current	NNS
cord-006229-7yoilsho	2911	11	.	.	.
cord-006229-7yoilsho	2912	1	The	the	DT
cord-006229-7yoilsho	2912	2	K	K	NNP
cord-006229-7yoilsho	2912	3	V	V	NNP
cord-006229-7yoilsho	2912	4	7.2	7.2	CD
cord-006229-7yoilsho	2912	5	-	-	SYM
cord-006229-7yoilsho	2912	6	5	5	CD
cord-006229-7yoilsho	2912	7	opener	opener	NN
cord-006229-7yoilsho	2912	8	retigabine	retigabine	NN
cord-006229-7yoilsho	2912	9	caused	cause	VBD
cord-006229-7yoilsho	2912	10	similar	similar	JJ
cord-006229-7yoilsho	2912	11	relaxations	relaxation	NNS
cord-006229-7yoilsho	2912	12	in	in	IN
cord-006229-7yoilsho	2912	13	Kcnq1-/-and	kcnq1-/-and	DT
cord-006229-7yoilsho	2912	14	wild	wild	JJ
cord-006229-7yoilsho	2912	15	-	-	HYPH
cord-006229-7yoilsho	2912	16	type	type	NN
cord-006229-7yoilsho	2912	17	vessels	vessel	NNS
cord-006229-7yoilsho	2912	18	.	.	.
cord-006229-7yoilsho	2913	1	We	-PRON-	PRP
cord-006229-7yoilsho	2913	2	conclude	conclude	VBP
cord-006229-7yoilsho	2913	3	that	that	IN
cord-006229-7yoilsho	2913	4	K	K	NNP
cord-006229-7yoilsho	2913	5	V	v	NN
cord-006229-7yoilsho	2913	6	7.1	7.1	CD
cord-006229-7yoilsho	2913	7	channels	channel	NNS
cord-006229-7yoilsho	2913	8	are	be	VBP
cord-006229-7yoilsho	2913	9	apparently	apparently	RB
cord-006229-7yoilsho	2913	10	not	not	RB
cord-006229-7yoilsho	2913	11	involved	involve	VBN
cord-006229-7yoilsho	2913	12	in	in	IN
cord-006229-7yoilsho	2913	13	the	the	DT
cord-006229-7yoilsho	2913	14	control	control	NN
cord-006229-7yoilsho	2913	15	of	of	IN
cord-006229-7yoilsho	2913	16	arterial	arterial	JJ
cord-006229-7yoilsho	2913	17	tone	tone	NN
cord-006229-7yoilsho	2913	18	by	by	IN
cord-006229-7yoilsho	2913	19	alpha	alpha	NN
cord-006229-7yoilsho	2913	20	1	1	CD
cord-006229-7yoilsho	2913	21	adrenergic	adrenergic	JJ
cord-006229-7yoilsho	2913	22	vasoconstrictors	vasoconstrictor	NNS
cord-006229-7yoilsho	2913	23	and	and	CC
cord-006229-7yoilsho	2913	24	PVAT	PVAT	NNS
cord-006229-7yoilsho	2913	25	.	.	.
cord-006229-7yoilsho	2914	1	In	in	IN
cord-006229-7yoilsho	2914	2	addition	addition	NN
cord-006229-7yoilsho	2914	3	,	,	,
cord-006229-7yoilsho	2914	4	R	R	NNP
cord-006229-7yoilsho	2914	5	-	-	HYPH
cord-006229-7yoilsho	2914	6	L3	L3	NNP
cord-006229-7yoilsho	2914	7	is	be	VBZ
cord-006229-7yoilsho	2914	8	an	an	DT
cord-006229-7yoilsho	2914	9	inappropriate	inappropriate	JJ
cord-006229-7yoilsho	2914	10	pharmacological	pharmacological	JJ
cord-006229-7yoilsho	2914	11	tool	tool	NN
cord-006229-7yoilsho	2914	12	for	for	IN
cord-006229-7yoilsho	2914	13	studying	study	VBG
cord-006229-7yoilsho	2914	14	the	the	DT
cord-006229-7yoilsho	2914	15	function	function	NN
cord-006229-7yoilsho	2914	16	of	of	IN
cord-006229-7yoilsho	2914	17	native	native	JJ
cord-006229-7yoilsho	2914	18	vascular	vascular	JJ
cord-006229-7yoilsho	2914	19	K	k	NN
cord-006229-7yoilsho	2914	20	V	v	NN
cord-006229-7yoilsho	2914	21	7.1	7.1	CD
cord-006229-7yoilsho	2914	22	channels	channel	NNS
cord-006229-7yoilsho	2914	23	in	in	IN
cord-006229-7yoilsho	2914	24	mice	mouse	NNS
cord-006229-7yoilsho	2914	25	.	.	.
cord-006229-7yoilsho	2915	1	Introduction	introduction	NN
cord-006229-7yoilsho	2915	2	:	:	:
cord-006229-7yoilsho	2916	1	According	accord	VBG
cord-006229-7yoilsho	2916	2	to	to	IN
cord-006229-7yoilsho	2916	3	international	international	JJ
cord-006229-7yoilsho	2916	4	guidelines	guideline	NNS
cord-006229-7yoilsho	2916	5	[	[	-LRB-
cord-006229-7yoilsho	2916	6	1	1	CD
cord-006229-7yoilsho	2916	7	]	]	-RRB-
cord-006229-7yoilsho	2916	8	[	[	-LRB-
cord-006229-7yoilsho	2916	9	2	2	CD
cord-006229-7yoilsho	2916	10	]	]	-RRB-
cord-006229-7yoilsho	2916	11	[	[	-LRB-
cord-006229-7yoilsho	2916	12	3	3	CD
cord-006229-7yoilsho	2916	13	]	]	-RRB-
cord-006229-7yoilsho	2916	14	[	[	-LRB-
cord-006229-7yoilsho	2916	15	4	4	CD
cord-006229-7yoilsho	2916	16	]	]	-RRB-
cord-006229-7yoilsho	2916	17	[	[	-LRB-
cord-006229-7yoilsho	2916	18	5	5	CD
cord-006229-7yoilsho	2916	19	]	]	-RRB-
cord-006229-7yoilsho	2916	20	[	[	-LRB-
cord-006229-7yoilsho	2916	21	6	6	CD
cord-006229-7yoilsho	2916	22	]	]	-RRB-
cord-006229-7yoilsho	2916	23	[	[	-LRB-
cord-006229-7yoilsho	2916	24	7	7	CD
cord-006229-7yoilsho	2916	25	]	]	-RRB-
cord-006229-7yoilsho	2916	26	,	,	,
cord-006229-7yoilsho	2916	27	both	both	CC
cord-006229-7yoilsho	2916	28	human	human	JJ
cord-006229-7yoilsho	2916	29	and	and	CC
cord-006229-7yoilsho	2916	30	animal	animal	NN
cord-006229-7yoilsho	2916	31	skin	skin	NN
cord-006229-7yoilsho	2916	32	in	in	IN
cord-006229-7yoilsho	2916	33	vitro	vitro	FW
cord-006229-7yoilsho	2916	34	models	model	NNS
cord-006229-7yoilsho	2916	35	have	have	VBP
cord-006229-7yoilsho	2916	36	been	be	VBN
cord-006229-7yoilsho	2916	37	used	use	VBN
cord-006229-7yoilsho	2916	38	and	and	CC
cord-006229-7yoilsho	2916	39	validated	validate	VBN
cord-006229-7yoilsho	2916	40	to	to	TO
cord-006229-7yoilsho	2916	41	predict	predict	VB
cord-006229-7yoilsho	2916	42	percutaneous	percutaneous	JJ
cord-006229-7yoilsho	2916	43	penetration	penetration	NN
cord-006229-7yoilsho	2916	44	in	in	IN
cord-006229-7yoilsho	2916	45	humans	human	NNS
cord-006229-7yoilsho	2916	46	.	.	.
cord-006229-7yoilsho	2917	1	Excellent	excellent	JJ
cord-006229-7yoilsho	2917	2	correlations	correlation	NNS
cord-006229-7yoilsho	2917	3	have	have	VBP
cord-006229-7yoilsho	2917	4	been	be	VBN
cord-006229-7yoilsho	2917	5	found	find	VBN
cord-006229-7yoilsho	2917	6	for	for	IN
cord-006229-7yoilsho	2917	7	domestic	domestic	JJ
cord-006229-7yoilsho	2917	8	pig	pig	NN
cord-006229-7yoilsho	2917	9	as	as	IN
cord-006229-7yoilsho	2917	10	surrogate	surrogate	NN
cord-006229-7yoilsho	2917	11	for	for	IN
cord-006229-7yoilsho	2917	12	human	human	JJ
cord-006229-7yoilsho	2917	13	skin	skin	NN
cord-006229-7yoilsho	2917	14	[	[	-LRB-
cord-006229-7yoilsho	2917	15	8	8	CD
cord-006229-7yoilsho	2917	16	]	]	-RRB-
cord-006229-7yoilsho	2917	17	[	[	-LRB-
cord-006229-7yoilsho	2917	18	9	9	CD
cord-006229-7yoilsho	2917	19	]	]	-RRB-
cord-006229-7yoilsho	2917	20	.	.	.
cord-006229-7yoilsho	2918	1	Material	material	NN
cord-006229-7yoilsho	2918	2	and	and	CC
cord-006229-7yoilsho	2918	3	Methods	method	NNS
cord-006229-7yoilsho	2918	4	:	:	:
cord-006229-7yoilsho	2919	1	Tissue	tissue	NN
cord-006229-7yoilsho	2920	1	The	the	DT
cord-006229-7yoilsho	2920	2	skin	skin	NN
cord-006229-7yoilsho	2920	3	samples	sample	NNS
cord-006229-7yoilsho	2920	4	are	be	VBP
cord-006229-7yoilsho	2920	5	descended	descend	VBN
cord-006229-7yoilsho	2920	6	from	from	IN
cord-006229-7yoilsho	2920	7	female	female	JJ
cord-006229-7yoilsho	2920	8	pigs	pig	NNS
cord-006229-7yoilsho	2920	9	of	of	IN
cord-006229-7yoilsho	2920	10	German	German	NNP
cord-006229-7yoilsho	2920	11	Landrace	Landrace	NNP
cord-006229-7yoilsho	2920	12	(	(	-LRB-
cord-006229-7yoilsho	2920	13	50	50	CD
cord-006229-7yoilsho	2920	14	kg	kg	NN
cord-006229-7yoilsho	2920	15	weight	weight	NN
cord-006229-7yoilsho	2920	16	,	,	,
cord-006229-7yoilsho	2920	17	approx	approx	NN
cord-006229-7yoilsho	2920	18	.	.	.
cord-006229-7yoilsho	2920	19	4	4	CD
cord-006229-7yoilsho	2920	20	month	month	NN
cord-006229-7yoilsho	2920	21	)	)	-RRB-
cord-006229-7yoilsho	2920	22	.	.	.
cord-006229-7yoilsho	2921	1	Process	process	NN
cord-006229-7yoilsho	2921	2	approved	approve	VBN
cord-006229-7yoilsho	2921	3	under	under	IN
cord-006229-7yoilsho	2921	4	German	German	NNP
cord-006229-7yoilsho	2921	5	Welfare	Welfare	NNP
cord-006229-7yoilsho	2921	6	Law	Law	NNP
cord-006229-7yoilsho	2921	7	.	.	.
cord-006229-7yoilsho	2922	1	After	after	IN
cord-006229-7yoilsho	2922	2	narcotization	narcotization	NNP
cord-006229-7yoilsho	2922	3	and	and	CC
cord-006229-7yoilsho	2922	4	euthanization	euthanization	NN
cord-006229-7yoilsho	2922	5	the	the	DT
cord-006229-7yoilsho	2922	6	animals	animal	NNS
cord-006229-7yoilsho	2922	7	were	be	VBD
cord-006229-7yoilsho	2922	8	shaved	shave	VBN
cord-006229-7yoilsho	2922	9	with	with	IN
cord-006229-7yoilsho	2922	10	an	an	DT
cord-006229-7yoilsho	2922	11	electric	electric	JJ
cord-006229-7yoilsho	2922	12	shaver	shaver	NN
cord-006229-7yoilsho	2922	13	,	,	,
cord-006229-7yoilsho	2922	14	washed	wash	VBD
cord-006229-7yoilsho	2922	15	and	and	CC
cord-006229-7yoilsho	2922	16	dried	dry	VBN
cord-006229-7yoilsho	2922	17	.	.	.
cord-006229-7yoilsho	2923	1	Microbiological	microbiological	JJ
cord-006229-7yoilsho	2923	2	investigation	investigation	NN
cord-006229-7yoilsho	2923	3	swabs	swab	NNS
cord-006229-7yoilsho	2923	4	from	from	IN
cord-006229-7yoilsho	2923	5	10	10	CD
cord-006229-7yoilsho	2923	6	different	different	JJ
cord-006229-7yoilsho	2923	7	skin	skin	NN
cord-006229-7yoilsho	2923	8	area	area	NN
cord-006229-7yoilsho	2923	9	(	(	-LRB-
cord-006229-7yoilsho	2923	10	Fig	Fig	NNP
cord-006229-7yoilsho	2923	11	.	.	.
cord-006229-7yoilsho	2923	12	1	1	CD
cord-006229-7yoilsho	2923	13	)	)	-RRB-
cord-006229-7yoilsho	2923	14	were	be	VBD
cord-006229-7yoilsho	2923	15	taken	take	VBN
cord-006229-7yoilsho	2923	16	before	before	RB
cord-006229-7yoilsho	2923	17	next	next	JJ
cord-006229-7yoilsho	2923	18	preparation	preparation	NN
cord-006229-7yoilsho	2923	19	step	step	NN
cord-006229-7yoilsho	2923	20	.	.	.
cord-006229-7yoilsho	2924	1	Skin	skin	NN
cord-006229-7yoilsho	2924	2	areas	area	NNS
cord-006229-7yoilsho	2924	3	were	be	VBD
cord-006229-7yoilsho	2924	4	cut	cut	VBN
cord-006229-7yoilsho	2924	5	,	,	,
cord-006229-7yoilsho	2924	6	stretched	stretched	JJ
cord-006229-7yoilsho	2924	7	and	and	CC
cord-006229-7yoilsho	2924	8	subcutaneous	subcutaneous	JJ
cord-006229-7yoilsho	2924	9	fatty	fatty	JJ
cord-006229-7yoilsho	2924	10	tissue	tissue	NN
cord-006229-7yoilsho	2924	11	was	be	VBD
cord-006229-7yoilsho	2924	12	carefully	carefully	RB
cord-006229-7yoilsho	2924	13	removed	remove	VBN
cord-006229-7yoilsho	2924	14	.	.	.
cord-006229-7yoilsho	2925	1	The	the	DT
cord-006229-7yoilsho	2925	2	skin	skin	NN
cord-006229-7yoilsho	2925	3	was	be	VBD
cord-006229-7yoilsho	2925	4	harvested	harvest	VBN
cord-006229-7yoilsho	2925	5	at	at	IN
cord-006229-7yoilsho	2925	6	thickness	thickness	NN
cord-006229-7yoilsho	2925	7	of	of	IN
cord-006229-7yoilsho	2925	8	1.000	1.000	CD
cord-006229-7yoilsho	2925	9	µm	µm	NN
cord-006229-7yoilsho	2925	10	by	by	IN
cord-006229-7yoilsho	2925	11	dermatome	dermatome	NN
cord-006229-7yoilsho	2925	12	.	.	.
cord-006229-7yoilsho	2926	1	After	after	IN
cord-006229-7yoilsho	2926	2	dermatomization	dermatomization	NN
cord-006229-7yoilsho	2926	3	,	,	,
cord-006229-7yoilsho	2926	4	samples	sample	NNS
cord-006229-7yoilsho	2926	5	were	be	VBD
cord-006229-7yoilsho	2926	6	taken	take	VBN
cord-006229-7yoilsho	2926	7	for	for	IN
cord-006229-7yoilsho	2926	8	histological	histological	JJ
cord-006229-7yoilsho	2926	9	examination	examination	NN
cord-006229-7yoilsho	2926	10	.	.	.
cord-006229-7yoilsho	2927	1	Skin	skin	NN
cord-006229-7yoilsho	2927	2	disks	disk	NNS
cord-006229-7yoilsho	2927	3	of	of	IN
cord-006229-7yoilsho	2927	4	30	30	CD
cord-006229-7yoilsho	2927	5	mm	mm	NNS
cord-006229-7yoilsho	2927	6	were	be	VBD
cord-006229-7yoilsho	2927	7	punched	punch	VBN
cord-006229-7yoilsho	2927	8	out	out	RP
cord-006229-7yoilsho	2927	9	from	from	IN
cord-006229-7yoilsho	2927	10	the	the	DT
cord-006229-7yoilsho	2927	11	frozen	frozen	JJ
cord-006229-7yoilsho	2927	12	skin	skin	NN
cord-006229-7yoilsho	2927	13	stripes	stripe	NNS
cord-006229-7yoilsho	2927	14	and	and	CC
cord-006229-7yoilsho	2927	15	stored	store	VBN
cord-006229-7yoilsho	2927	16	at	at	IN
cord-006229-7yoilsho	2927	17	-20	-20	NNP
cord-006229-7yoilsho	2927	18	°	°	NN
cord-006229-7yoilsho	2927	19	C	C	NNP
cord-006229-7yoilsho	2927	20	.	.	.
cord-006229-7yoilsho	2928	1	HPLC	HPLC	NNP
cord-006229-7yoilsho	2928	2	and	and	CC
cord-006229-7yoilsho	2928	3	Skin	Skin	NNP
cord-006229-7yoilsho	2928	4	Absorption	Absorption	NNP
cord-006229-7yoilsho	2928	5	Waters	Waters	NNPS
cord-006229-7yoilsho	2928	6	Corporation	Corporation	NNP
cord-006229-7yoilsho	2928	7	HPLC	HPLC	NNP
cord-006229-7yoilsho	2928	8	containing	contain	VBG
cord-006229-7yoilsho	2928	9	2767	2767	CD
cord-006229-7yoilsho	2928	10	Sample	Sample	NNP
cord-006229-7yoilsho	2928	11	Manager	Manager	NNP
cord-006229-7yoilsho	2928	12	,	,	,
cord-006229-7yoilsho	2928	13	2545	2545	CD
cord-006229-7yoilsho	2928	14	binary	binary	JJ
cord-006229-7yoilsho	2928	15	gradient	gradient	NN
cord-006229-7yoilsho	2928	16	pump	pump	NN
cord-006229-7yoilsho	2928	17	,	,	,
cord-006229-7yoilsho	2928	18	2998	2998	CD
cord-006229-7yoilsho	2928	19	PDA	pda	NN
cord-006229-7yoilsho	2928	20	detector	detector	NN
cord-006229-7yoilsho	2928	21	(	(	-LRB-
cord-006229-7yoilsho	2928	22	optional	optional	JJ
cord-006229-7yoilsho	2928	23	:	:	:
cord-006229-7yoilsho	2928	24	3100	3100	CD
cord-006229-7yoilsho	2928	25	electron	electron	NN
cord-006229-7yoilsho	2928	26	spray	spray	NN
cord-006229-7yoilsho	2928	27	mass	mass	NN
cord-006229-7yoilsho	2928	28	spectrometer	spectrometer	NN
cord-006229-7yoilsho	2928	29	)	)	-RRB-
cord-006229-7yoilsho	2928	30	;	;	:
cord-006229-7yoilsho	2928	31	Column	column	NN
cord-006229-7yoilsho	2928	32	:	:	:
cord-006229-7yoilsho	2928	33	NUCLEODUR	NUCLEODUR	NNP
cord-006229-7yoilsho	2929	1	®	®	NNP
cord-006229-7yoilsho	2929	2	100	100	CD
cord-006229-7yoilsho	2929	3	-	-	SYM
cord-006229-7yoilsho	2929	4	5	5	CD
cord-006229-7yoilsho	2929	5	C18	C18	NNP
cord-006229-7yoilsho	2929	6	ec	ec	NNP
cord-006229-7yoilsho	2929	7	50	50	CD
cord-006229-7yoilsho	2929	8	mm	mm	NNP
cord-006229-7yoilsho	2929	9	x	x	NN
cord-006229-7yoilsho	2930	1	4.0	4.0	CD
cord-006229-7yoilsho	2930	2	mm	mm	NN
cord-006229-7yoilsho	2930	3	ID	ID	NNP
cord-006229-7yoilsho	2930	4	.	.	.
cord-006229-7yoilsho	2931	1	Hanson	Hanson	NNP
cord-006229-7yoilsho	2931	2	Microette	Microette	NNP
cord-006229-7yoilsho	2932	1	™	™	``
cord-006229-7yoilsho	2932	2	Vision	Vision	NNP
cord-006229-7yoilsho	2932	3	®	®	.
cord-006229-7yoilsho	2932	4	Diffusion	Diffusion	NNP
cord-006229-7yoilsho	2932	5	Test	Test	NNP
cord-006229-7yoilsho	2932	6	System	System	NNP
cord-006229-7yoilsho	2933	1	(	(	-LRB-
cord-006229-7yoilsho	2933	2	Hanson	Hanson	NNP
cord-006229-7yoilsho	2933	3	Vision	Vision	NNP
cord-006229-7yoilsho	2934	1	®	®	NNP
cord-006229-7yoilsho	2934	2	AutoPlus	AutoPlus	NNP
cord-006229-7yoilsho	2934	3	™	™	CC
cord-006229-7yoilsho	2934	4	autosampler	autosampler	NNP
cord-006229-7yoilsho	2934	5	/	/	SYM
cord-006229-7yoilsho	2934	6	AutoFill	AutoFill	NNP
cord-006229-7yoilsho	2934	7	™	™	NN
cord-006229-7yoilsho	2934	8	collector	collector	NN
cord-006229-7yoilsho	2934	9	,	,	.
cord-006229-7yoilsho	2935	1	6-Cell	6-cell	CD
cord-006229-7yoilsho	2935	2	Drive	Drive	NNP
cord-006229-7yoilsho	2935	3	System	System	NNP
cord-006229-7yoilsho	2935	4	with	with	IN
cord-006229-7yoilsho	2935	5	Vertical	Vertical	NNP
cord-006229-7yoilsho	2935	6	Diffusion	Diffusion	NNP
cord-006229-7yoilsho	2935	7	Cell	Cell	NNP
cord-006229-7yoilsho	2935	8	"	"	''
cord-006229-7yoilsho	2935	9	Standard	standard	NN
cord-006229-7yoilsho	2935	10	"	"	''
cord-006229-7yoilsho	2935	11	.	.	.
cord-006229-7yoilsho	2936	1	The	the	DT
cord-006229-7yoilsho	2936	2	permeation	permeation	NN
cord-006229-7yoilsho	2936	3	experiment	experiment	NN
cord-006229-7yoilsho	2936	4	was	be	VBD
cord-006229-7yoilsho	2936	5	performed	perform	VBN
cord-006229-7yoilsho	2936	6	over	over	IN
cord-006229-7yoilsho	2936	7	a	a	DT
cord-006229-7yoilsho	2936	8	period	period	NN
cord-006229-7yoilsho	2936	9	of	of	IN
cord-006229-7yoilsho	2936	10	48	48	CD
cord-006229-7yoilsho	2936	11	h	h	NN
cord-006229-7yoilsho	2936	12	at	at	IN
cord-006229-7yoilsho	2936	13	32	32	CD
cord-006229-7yoilsho	2936	14	°	°	NN
cord-006229-7yoilsho	2936	15	C	c	NN
cord-006229-7yoilsho	2936	16	.	.	.
cord-006229-7yoilsho	2937	1	The	the	DT
cord-006229-7yoilsho	2937	2	dosage	dosage	NN
cord-006229-7yoilsho	2937	3	compartments	compartment	NNS
cord-006229-7yoilsho	2937	4	of	of	IN
cord-006229-7yoilsho	2937	5	each	each	DT
cord-006229-7yoilsho	2937	6	cell	cell	NN
cord-006229-7yoilsho	2937	7	were	be	VBD
cord-006229-7yoilsho	2937	8	filled	fill	VBN
cord-006229-7yoilsho	2937	9	with	with	IN
cord-006229-7yoilsho	2937	10	approximately	approximately	RB
cord-006229-7yoilsho	2937	11	300	300	CD
cord-006229-7yoilsho	2937	12	µL	µl	CD
cord-006229-7yoilsho	2937	13	of	of	IN
cord-006229-7yoilsho	2937	14	the	the	DT
cord-006229-7yoilsho	2937	15	caffeine	caffeine	NN
cord-006229-7yoilsho	2937	16	solution	solution	NN
cord-006229-7yoilsho	2937	17	(	(	-LRB-
cord-006229-7yoilsho	2937	18	10	10	CD
cord-006229-7yoilsho	2937	19	mg	mg	NNP
cord-006229-7yoilsho	2937	20	/	/	SYM
cord-006229-7yoilsho	2937	21	mL	mL	NNP
cord-006229-7yoilsho	2937	22	)	)	-RRB-
cord-006229-7yoilsho	2937	23	.	.	.
cord-006229-7yoilsho	2938	1	Samples	sample	NNS
cord-006229-7yoilsho	2938	2	of	of	IN
cord-006229-7yoilsho	2938	3	1	1	CD
cord-006229-7yoilsho	2938	4	mL	ml	NN
cord-006229-7yoilsho	2938	5	are	be	VBP
cord-006229-7yoilsho	2938	6	taken	take	VBN
cord-006229-7yoilsho	2938	7	after	after	IN
cord-006229-7yoilsho	2938	8	0	0	CD
cord-006229-7yoilsho	2938	9	,	,	,
cord-006229-7yoilsho	2938	10	12	12	CD
cord-006229-7yoilsho	2938	11	,	,	,
cord-006229-7yoilsho	2938	12	24	24	CD
cord-006229-7yoilsho	2938	13	,	,	,
cord-006229-7yoilsho	2938	14	36	36	CD
cord-006229-7yoilsho	2938	15	and	and	CC
cord-006229-7yoilsho	2938	16	48	48	CD
cord-006229-7yoilsho	2938	17	hours	hour	NNS
cord-006229-7yoilsho	2938	18	from	from	IN
cord-006229-7yoilsho	2938	19	receptor	receptor	NN
cord-006229-7yoilsho	2938	20	medium	medium	NN
cord-006229-7yoilsho	2938	21	of	of	IN
cord-006229-7yoilsho	2938	22	each	each	DT
cord-006229-7yoilsho	2938	23	cell	cell	NN
cord-006229-7yoilsho	2938	24	.	.	.
cord-006229-7yoilsho	2939	1	Aliquots	aliquot	NNS
cord-006229-7yoilsho	2939	2	from	from	IN
cord-006229-7yoilsho	2939	3	each	each	DT
cord-006229-7yoilsho	2939	4	VDC	VDC	NNP
cord-006229-7yoilsho	2939	5	are	be	VBP
cord-006229-7yoilsho	2939	6	analyzed	analyze	VBN
cord-006229-7yoilsho	2939	7	by	by	IN
cord-006229-7yoilsho	2939	8	HPLC	HPLC	NNP
cord-006229-7yoilsho	2939	9	in	in	IN
cord-006229-7yoilsho	2939	10	duplicate	duplicate	NN
cord-006229-7yoilsho	2939	11	.	.	.
cord-006229-7yoilsho	2940	1	Microbiology	Microbiology	NNP
cord-006229-7yoilsho	2940	2	Staphylococcus	Staphylococcus	NNP
cord-006229-7yoilsho	2940	3	spp	spp	NN
cord-006229-7yoilsho	2940	4	.	.	.
cord-006229-7yoilsho	2941	1	were	be	VBD
cord-006229-7yoilsho	2941	2	found	find	VBN
cord-006229-7yoilsho	2941	3	explicitly	explicitly	RB
cord-006229-7yoilsho	2941	4	on	on	IN
cord-006229-7yoilsho	2941	5	pig	pig	NN
cord-006229-7yoilsho	2941	6	skin	skin	NN
cord-006229-7yoilsho	2941	7	surface	surface	NN
cord-006229-7yoilsho	2941	8	.	.	.
cord-006229-7yoilsho	2942	1	Bacteria	Bacteria	NNS
cord-006229-7yoilsho	2942	2	are	be	VBP
cord-006229-7yoilsho	2942	3	facultative	facultative	JJ
cord-006229-7yoilsho	2942	4	anaerobe	anaerobe	NN
cord-006229-7yoilsho	2942	5	,	,	,
cord-006229-7yoilsho	2942	6	gram	gram	NN
cord-006229-7yoilsho	2942	7	-	-	HYPH
cord-006229-7yoilsho	2942	8	positive	positive	JJ
cord-006229-7yoilsho	2942	9	bacteria	bacteria	NNS
cord-006229-7yoilsho	2942	10	that	that	WDT
cord-006229-7yoilsho	2942	11	are	be	VBP
cord-006229-7yoilsho	2942	12	physiologically	physiologically	RB
cord-006229-7yoilsho	2942	13	colonizing	colonize	VBG
cord-006229-7yoilsho	2942	14	the	the	DT
cord-006229-7yoilsho	2942	15	skin	skin	NN
cord-006229-7yoilsho	2942	16	,	,	,
cord-006229-7yoilsho	2942	17	oropharynx	oropharynx	NN
cord-006229-7yoilsho	2942	18	and	and	CC
cord-006229-7yoilsho	2942	19	the	the	DT
cord-006229-7yoilsho	2942	20	gastrointestinal	gastrointestinal	JJ
cord-006229-7yoilsho	2942	21	tract	tract	NN
cord-006229-7yoilsho	2942	22	.	.	.
cord-006229-7yoilsho	2943	1	Histology	histology	NN
cord-006229-7yoilsho	2943	2	and	and	CC
cord-006229-7yoilsho	2943	3	Skin	skin	NN
cord-006229-7yoilsho	2943	4	thickness	thickness	NN
cord-006229-7yoilsho	2943	5	HE	he	PRP
cord-006229-7yoilsho	2943	6	staining	stain	VBG
cord-006229-7yoilsho	2943	7	and	and	CC
cord-006229-7yoilsho	2943	8	mechanical	mechanical	JJ
cord-006229-7yoilsho	2943	9	skin	skin	NN
cord-006229-7yoilsho	2943	10	thickness	thickness	NN
cord-006229-7yoilsho	2943	11	determinations	determination	NNS
cord-006229-7yoilsho	2943	12	confirmed	confirm	VBD
cord-006229-7yoilsho	2943	13	intact	intact	JJ
cord-006229-7yoilsho	2943	14	dermatomizing	dermatomize	VBG
cord-006229-7yoilsho	2943	15	process	process	NN
cord-006229-7yoilsho	2943	16	of	of	IN
cord-006229-7yoilsho	2943	17	skin	skin	NN
cord-006229-7yoilsho	2943	18	(	(	-LRB-
cord-006229-7yoilsho	2943	19	Fig	Fig	NNP
cord-006229-7yoilsho	2943	20	.	.	NNP
cord-006229-7yoilsho	2943	21	2	2	CD
cord-006229-7yoilsho	2943	22	)	)	-RRB-
cord-006229-7yoilsho	2943	23	.	.	.
cord-006229-7yoilsho	2944	1	Thickness	thickness	NN
cord-006229-7yoilsho	2944	2	was	be	VBD
cord-006229-7yoilsho	2944	3	in	in	IN
cord-006229-7yoilsho	2944	4	the	the	DT
cord-006229-7yoilsho	2944	5	order	order	NN
cord-006229-7yoilsho	2944	6	of	of	IN
cord-006229-7yoilsho	2944	7	magnitude	magnitude	NN
cord-006229-7yoilsho	2944	8	between	between	IN
cord-006229-7yoilsho	2944	9	897	897	CD
cord-006229-7yoilsho	2944	10	to	to	TO
cord-006229-7yoilsho	2944	11	1.230	1.230	CD
cord-006229-7yoilsho	2944	12	µm	µm	NN
cord-006229-7yoilsho	2944	13	and	and	CC
cord-006229-7yoilsho	2944	14	intra	intra	JJ
cord-006229-7yoilsho	2944	15	variations	variation	NNS
cord-006229-7yoilsho	2944	16	were	be	VBD
cord-006229-7yoilsho	2944	17	less	less	JJR
cord-006229-7yoilsho	2944	18	than	than	IN
cord-006229-7yoilsho	2944	19	10	10	CD
cord-006229-7yoilsho	2944	20	%	%	NN
cord-006229-7yoilsho	2944	21	.	.	.
cord-006229-7yoilsho	2945	1	Caffeine	caffeine	NN
cord-006229-7yoilsho	2945	2	Skin	skin	NN
cord-006229-7yoilsho	2945	3	absorption	absorption	NN
cord-006229-7yoilsho	2945	4	Permeability	permeability	NN
cord-006229-7yoilsho	2945	5	coefficients	coefficient	NNS
cord-006229-7yoilsho	2945	6	and	and	CC
cord-006229-7yoilsho	2945	7	lag	lag	NN
cord-006229-7yoilsho	2945	8	-	-	HYPH
cord-006229-7yoilsho	2945	9	phases	phase	NNS
cord-006229-7yoilsho	2945	10	recorded	record	VBN
cord-006229-7yoilsho	2945	11	are	be	VBP
cord-006229-7yoilsho	2945	12	in	in	IN
cord-006229-7yoilsho	2945	13	the	the	DT
cord-006229-7yoilsho	2945	14	same	same	JJ
cord-006229-7yoilsho	2945	15	order	order	NN
cord-006229-7yoilsho	2945	16	of	of	IN
cord-006229-7yoilsho	2945	17	magnitude	magnitude	NN
cord-006229-7yoilsho	2945	18	of	of	IN
cord-006229-7yoilsho	2945	19	previous	previous	JJ
cord-006229-7yoilsho	2945	20	work	work	NN
cord-006229-7yoilsho	2945	21	[	[	-LRB-
cord-006229-7yoilsho	2945	22	10	10	CD
cord-006229-7yoilsho	2945	23	]	]	-RRB-
cord-006229-7yoilsho	2945	24	,	,	,
cord-006229-7yoilsho	2945	25	demonstrating	demonstrate	VBG
cord-006229-7yoilsho	2945	26	intact	intact	JJ
cord-006229-7yoilsho	2945	27	barrier	barrier	NN
cord-006229-7yoilsho	2945	28	properties	property	NNS
cord-006229-7yoilsho	2945	29	of	of	IN
cord-006229-7yoilsho	2945	30	the	the	DT
cord-006229-7yoilsho	2945	31	membranes	membrane	NNS
cord-006229-7yoilsho	2945	32	after	after	IN
cord-006229-7yoilsho	2945	33	3	3	CD
cord-006229-7yoilsho	2945	34	month	month	NN
cord-006229-7yoilsho	2945	35	storage	storage	NN
cord-006229-7yoilsho	2945	36	process	process	NN
cord-006229-7yoilsho	2945	37	.	.	.
cord-006229-7yoilsho	2946	1	Until	until	IN
cord-006229-7yoilsho	2946	2	today	today	NN
cord-006229-7yoilsho	2946	3	,	,	,
cord-006229-7yoilsho	2946	4	intra	intra	JJ
cord-006229-7yoilsho	2946	5	-	-	JJ
cord-006229-7yoilsho	2946	6	assay	assay	JJ
cord-006229-7yoilsho	2946	7	variations	variation	NNS
cord-006229-7yoilsho	2946	8	are	be	VBP
cord-006229-7yoilsho	2946	9	superior	superior	JJ
cord-006229-7yoilsho	2946	10	or	or	CC
cord-006229-7yoilsho	2946	11	equal	equal	JJ
cord-006229-7yoilsho	2946	12	to	to	IN
cord-006229-7yoilsho	2946	13	interregional	interregional	JJ
cord-006229-7yoilsho	2946	14	and	and	CC
cord-006229-7yoilsho	2946	15	inter	inter	JJ
cord-006229-7yoilsho	2946	16	-	-	JJ
cord-006229-7yoilsho	2946	17	animal	animal	JJ
cord-006229-7yoilsho	2946	18	variations	variation	NNS
cord-006229-7yoilsho	2946	19	.	.	.
cord-006229-7yoilsho	2947	1	Discussion	discussion	NN
cord-006229-7yoilsho	2947	2	:	:	:
cord-006229-7yoilsho	2948	1	Well	well	UH
cord-006229-7yoilsho	2948	2	characterized	characterized	JJ
cord-006229-7yoilsho	2948	3	DPS1000	DPS1000	NNP
cord-006229-7yoilsho	2948	4	provides	provide	VBZ
cord-006229-7yoilsho	2948	5	ready	ready	JJ
cord-006229-7yoilsho	2948	6	to	to	TO
cord-006229-7yoilsho	2948	7	use	use	VB
cord-006229-7yoilsho	2948	8	research	research	NN
cord-006229-7yoilsho	2948	9	tool	tool	NN
cord-006229-7yoilsho	2948	10	for	for	IN
cord-006229-7yoilsho	2948	11	locally	locally	RB
cord-006229-7yoilsho	2948	12	and	and	CC
cord-006229-7yoilsho	2948	13	systemic	systemic	JJ
cord-006229-7yoilsho	2948	14	skin	skin	NN
cord-006229-7yoilsho	2948	15	investigations	investigation	NNS
cord-006229-7yoilsho	2948	16	.	.	.
cord-006229-7yoilsho	2949	1	Ongoing	ongoing	JJ
cord-006229-7yoilsho	2949	2	experiments	experiment	NNS
cord-006229-7yoilsho	2949	3	will	will	MD
cord-006229-7yoilsho	2949	4	cover	cover	VB
cord-006229-7yoilsho	2949	5	skin	skin	NN
cord-006229-7yoilsho	2949	6	structure	structure	NN
cord-006229-7yoilsho	2949	7	analysis	analysis	NN
cord-006229-7yoilsho	2949	8	by	by	IN
cord-006229-7yoilsho	2949	9	Raman	Raman	NNP
cord-006229-7yoilsho	2949	10	Spectroscopy	Spectroscopy	NNP
cord-006229-7yoilsho	2949	11	,	,	,
cord-006229-7yoilsho	2949	12	Biophotonics	Biophotonics	NNP
cord-006229-7yoilsho	2949	13	and	and	CC
cord-006229-7yoilsho	2949	14	storage	storage	NN
cord-006229-7yoilsho	2949	15	impact	impact	NN
cord-006229-7yoilsho	2949	16	on	on	IN
cord-006229-7yoilsho	2949	17	skin	skin	NN
cord-006229-7yoilsho	2949	18	barrier	barrier	NN
cord-006229-7yoilsho	2949	19	function	function	NN
cord-006229-7yoilsho	2949	20	.	.	.
cord-006229-7yoilsho	2950	1	Respirable	respirable	JJ
cord-006229-7yoilsho	2950	2	biopersistent	biopersistent	NN
cord-006229-7yoilsho	2950	3	granular	granular	JJ
cord-006229-7yoilsho	2950	4	dusts	dust	NNS
cord-006229-7yoilsho	2950	5	(	(	-LRB-
cord-006229-7yoilsho	2950	6	GBS	GBS	NNP
cord-006229-7yoilsho	2950	7	)	)	-RRB-
cord-006229-7yoilsho	2950	8	should	should	MD
cord-006229-7yoilsho	2950	9	fulfill	fulfill	VB
cord-006229-7yoilsho	2950	10	the	the	DT
cord-006229-7yoilsho	2950	11	criteria	criterion	NNS
cord-006229-7yoilsho	2950	12	of	of	IN
cord-006229-7yoilsho	2950	13	i.	i.	NN
cord-006229-7yoilsho	2950	14	)	)	-RRB-
cord-006229-7yoilsho	2951	1	a	a	DT
cord-006229-7yoilsho	2951	2	negligible	negligible	JJ
cord-006229-7yoilsho	2951	3	solubility	solubility	NN
cord-006229-7yoilsho	2951	4	in	in	IN
cord-006229-7yoilsho	2951	5	physiological	physiological	JJ
cord-006229-7yoilsho	2951	6	lung	lung	NN
cord-006229-7yoilsho	2951	7	fluid	fluid	NN
cord-006229-7yoilsho	2951	8	that	that	WDT
cord-006229-7yoilsho	2951	9	ii	ii	NN
cord-006229-7yoilsho	2951	10	.	.	.
cord-006229-7yoilsho	2951	11	)	)	-RRB-
cord-006229-7yoilsho	2951	12	do	do	VBP
cord-006229-7yoilsho	2951	13	not	not	RB
cord-006229-7yoilsho	2951	14	exhibit	exhibit	VB
cord-006229-7yoilsho	2951	15	a	a	DT
cord-006229-7yoilsho	2951	16	specific	specific	JJ
cord-006229-7yoilsho	2951	17	surface	surface	NN
cord-006229-7yoilsho	2951	18	chemistryrelated	chemistryrelate	VBN
cord-006229-7yoilsho	2951	19	toxicity	toxicity	NN
cord-006229-7yoilsho	2951	20	at	at	IN
cord-006229-7yoilsho	2951	21	volumetric	volumetric	JJ
cord-006229-7yoilsho	2951	22	non	non	JJ
cord-006229-7yoilsho	2951	23	-	-	JJ
cord-006229-7yoilsho	2951	24	overload	overload	JJ
cord-006229-7yoilsho	2951	25	conditions	condition	NNS
cord-006229-7yoilsho	2951	26	in	in	IN
cord-006229-7yoilsho	2951	27	lungs	lung	NNS
cord-006229-7yoilsho	2951	28	.	.	.
cord-006229-7yoilsho	2952	1	In	in	IN
cord-006229-7yoilsho	2952	2	2012	2012	CD
cord-006229-7yoilsho	2952	3	,	,	,
cord-006229-7yoilsho	2952	4	the	the	DT
cord-006229-7yoilsho	2952	5	MAK	MAK	NNP
cord-006229-7yoilsho	2952	6	Commission	Commission	NNP
cord-006229-7yoilsho	2952	7	derived	derive	VBD
cord-006229-7yoilsho	2952	8	a	a	DT
cord-006229-7yoilsho	2952	9	new	new	JJ
cord-006229-7yoilsho	2952	10	threshold	threshold	NN
cord-006229-7yoilsho	2952	11	value	value	NN
cord-006229-7yoilsho	2952	12	of	of	IN
cord-006229-7yoilsho	2952	13	0.3	0.3	CD
cord-006229-7yoilsho	2952	14	mg	mg	NNP
cord-006229-7yoilsho	2952	15	/	/	SYM
cord-006229-7yoilsho	2952	16	m	m	NNP
cord-006229-7yoilsho	2952	17	3	3	CD
cord-006229-7yoilsho	2952	18	for	for	IN
cord-006229-7yoilsho	2952	19	GBS	GBS	NNP
cord-006229-7yoilsho	2952	20	with	with	IN
cord-006229-7yoilsho	2952	21	a	a	DT
cord-006229-7yoilsho	2952	22	density	density	NN
cord-006229-7yoilsho	2952	23	of	of	IN
cord-006229-7yoilsho	2952	24	1	1	CD
cord-006229-7yoilsho	2952	25	,	,	,
cord-006229-7yoilsho	2952	26	recognizing	recognize	VBG
cord-006229-7yoilsho	2952	27	that	that	IN
cord-006229-7yoilsho	2952	28	at	at	IN
cord-006229-7yoilsho	2952	29	this	this	DT
cord-006229-7yoilsho	2952	30	concentration	concentration	NN
cord-006229-7yoilsho	2952	31	a	a	DT
cord-006229-7yoilsho	2952	32	chronic	chronic	JJ
cord-006229-7yoilsho	2952	33	inflammation	inflammation	NN
cord-006229-7yoilsho	2952	34	and	and	CC
cord-006229-7yoilsho	2952	35	increase	increase	NN
cord-006229-7yoilsho	2952	36	of	of	IN
cord-006229-7yoilsho	2952	37	the	the	DT
cord-006229-7yoilsho	2952	38	lung	lung	NN
cord-006229-7yoilsho	2952	39	cancer	cancer	NN
cord-006229-7yoilsho	2952	40	risk	risk	NN
cord-006229-7yoilsho	2952	41	will	will	MD
cord-006229-7yoilsho	2952	42	not	not	RB
cord-006229-7yoilsho	2952	43	occur	occur	VB
cord-006229-7yoilsho	2952	44	.	.	.
cord-006229-7yoilsho	2953	1	-The	-the	WDT
cord-006229-7yoilsho	2953	2	objectives	objective	NNS
cord-006229-7yoilsho	2953	3	of	of	IN
cord-006229-7yoilsho	2953	4	the	the	DT
cord-006229-7yoilsho	2953	5	project	project	NN
cord-006229-7yoilsho	2953	6	were	be	VBD
cord-006229-7yoilsho	2953	7	i.	i.	NN
cord-006229-7yoilsho	2953	8	)	)	-RRB-
cord-006229-7yoilsho	2953	9	to	to	TO
cord-006229-7yoilsho	2953	10	determine	determine	VB
cord-006229-7yoilsho	2953	11	an	an	DT
cord-006229-7yoilsho	2953	12	experimental	experimental	JJ
cord-006229-7yoilsho	2953	13	dissolution	dissolution	NN
cord-006229-7yoilsho	2953	14	value	value	NN
cord-006229-7yoilsho	2953	15	for	for	IN
cord-006229-7yoilsho	2953	16	'	'	``
cord-006229-7yoilsho	2953	17	low	low	JJ
cord-006229-7yoilsho	2953	18	soluble	soluble	JJ
cord-006229-7yoilsho	2953	19	'	'	''
cord-006229-7yoilsho	2953	20	GBS	GBS	NNP
cord-006229-7yoilsho	2953	21	using	use	VBG
cord-006229-7yoilsho	2953	22	six	six	CD
cord-006229-7yoilsho	2953	23	candidate	candidate	NN
cord-006229-7yoilsho	2953	24	dusts	dust	NNS
cord-006229-7yoilsho	2953	25	;	;	:
cord-006229-7yoilsho	2953	26	ii	ii	NNP
cord-006229-7yoilsho	2953	27	.	.	.
cord-006229-7yoilsho	2953	28	)	)	-RRB-
cord-006229-7yoilsho	2954	1	in	in	IN
cord-006229-7yoilsho	2954	2	addition	addition	NN
cord-006229-7yoilsho	2954	3	,	,	,
cord-006229-7yoilsho	2954	4	to	to	TO
cord-006229-7yoilsho	2954	5	measure	measure	VB
cord-006229-7yoilsho	2954	6	the	the	DT
cord-006229-7yoilsho	2954	7	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	2954	8	response	response	NN
cord-006229-7yoilsho	2954	9	in	in	IN
cord-006229-7yoilsho	2954	10	lung	lung	NN
cord-006229-7yoilsho	2954	11	lavage	lavage	NN
cord-006229-7yoilsho	2954	12	fluid	fluid	NN
cord-006229-7yoilsho	2954	13	and	and	CC
cord-006229-7yoilsho	2954	14	to	to	TO
cord-006229-7yoilsho	2954	15	decide	decide	VB
cord-006229-7yoilsho	2954	16	on	on	IN
cord-006229-7yoilsho	2954	17	the	the	DT
cord-006229-7yoilsho	2954	18	criterion	criterion	NN
cord-006229-7yoilsho	2954	19	'	'	``
cord-006229-7yoilsho	2954	20	inert	inert	JJ
cord-006229-7yoilsho	2954	21	dust	dust	NN
cord-006229-7yoilsho	2954	22	'	'	''
cord-006229-7yoilsho	2954	23	;	;	:
cord-006229-7yoilsho	2954	24	iii	iii	NNP
cord-006229-7yoilsho	2954	25	.	.	.
cord-006229-7yoilsho	2954	26	)	)	-RRB-
cord-006229-7yoilsho	2954	27	to	to	TO
cord-006229-7yoilsho	2954	28	investigate	investigate	VB
cord-006229-7yoilsho	2954	29	whether	whether	IN
cord-006229-7yoilsho	2954	30	nanoscaled	nanoscale	VBN
cord-006229-7yoilsho	2954	31	dusts	dust	NNS
cord-006229-7yoilsho	2954	32	could	could	MD
cord-006229-7yoilsho	2954	33	possibly	possibly	RB
cord-006229-7yoilsho	2954	34	fulfill	fulfill	VB
cord-006229-7yoilsho	2954	35	the	the	DT
cord-006229-7yoilsho	2954	36	criteria	criterion	NNS
cord-006229-7yoilsho	2954	37	to	to	TO
cord-006229-7yoilsho	2954	38	be	be	VB
cord-006229-7yoilsho	2954	39	included	include	VBN
cord-006229-7yoilsho	2954	40	in	in	IN
cord-006229-7yoilsho	2954	41	the	the	DT
cord-006229-7yoilsho	2954	42	GBS	GBS	NNP
cord-006229-7yoilsho	2954	43	class	class	NN
cord-006229-7yoilsho	2954	44	.	.	.
cord-006229-7yoilsho	2955	1	-Six	-Six	:
cord-006229-7yoilsho	2955	2	micro	micro	JJ
cord-006229-7yoilsho	2955	3	-	-	HYPH
cord-006229-7yoilsho	2955	4	and	and	CC
cord-006229-7yoilsho	2955	5	nanoscaled	nanoscaled	JJ
cord-006229-7yoilsho	2955	6	dusts	dust	NNS
cord-006229-7yoilsho	2955	7	(	(	-LRB-
cord-006229-7yoilsho	2955	8	one	one	CD
cord-006229-7yoilsho	2955	9	of	of	IN
cord-006229-7yoilsho	2955	10	them	-PRON-	PRP
cord-006229-7yoilsho	2955	11	a	a	DT
cord-006229-7yoilsho	2955	12	well	well	RB
cord-006229-7yoilsho	2955	13	-	-	HYPH
cord-006229-7yoilsho	2955	14	characterised	characterise	VBN
cord-006229-7yoilsho	2955	15	inert	inert	JJ
cord-006229-7yoilsho	2955	16	TiO	tio	NN
cord-006229-7yoilsho	2955	17	2	2	CD
cord-006229-7yoilsho	2955	18	dust	dust	NN
cord-006229-7yoilsho	2955	19	(	(	-LRB-
cord-006229-7yoilsho	2955	20	microscaled	microscaled	JJ
cord-006229-7yoilsho	2955	21	;	;	:
cord-006229-7yoilsho	2955	22	rutile	rutile	NN
cord-006229-7yoilsho	2955	23	modification	modification	NN
cord-006229-7yoilsho	2955	24	)	)	-RRB-
cord-006229-7yoilsho	2955	25	were	be	VBD
cord-006229-7yoilsho	2955	26	compared	compare	VBN
cord-006229-7yoilsho	2955	27	analysing	analyse	VBG
cord-006229-7yoilsho	2955	28	the	the	DT
cord-006229-7yoilsho	2955	29	solubility	solubility	NN
cord-006229-7yoilsho	2955	30	in	in	IN
cord-006229-7yoilsho	2955	31	the	the	DT
cord-006229-7yoilsho	2955	32	lung	lung	NN
cord-006229-7yoilsho	2955	33	fluid	fluid	NN
cord-006229-7yoilsho	2955	34	(	(	-LRB-
cord-006229-7yoilsho	2955	35	day	day	NN
cord-006229-7yoilsho	2955	36	3	3	CD
cord-006229-7yoilsho	2955	37	,	,	,
cord-006229-7yoilsho	2955	38	28	28	CD
cord-006229-7yoilsho	2955	39	and	and	CC
cord-006229-7yoilsho	2955	40	90	90	CD
cord-006229-7yoilsho	2955	41	)	)	-RRB-
cord-006229-7yoilsho	2955	42	and	and	CC
cord-006229-7yoilsho	2955	43	the	the	DT
cord-006229-7yoilsho	2955	44	lung	lung	NN
cord-006229-7yoilsho	2955	45	toxicity	toxicity	NN
cord-006229-7yoilsho	2955	46	after	after	IN
cord-006229-7yoilsho	2955	47	intratracheal	intratracheal	NN
cord-006229-7yoilsho	2955	48	instillation	instillation	NN
cord-006229-7yoilsho	2955	49	in	in	IN
cord-006229-7yoilsho	2955	50	rats	rat	NNS
cord-006229-7yoilsho	2955	51	(	(	-LRB-
cord-006229-7yoilsho	2955	52	day	day	NN
cord-006229-7yoilsho	2955	53	3	3	CD
cord-006229-7yoilsho	2955	54	and	and	CC
cord-006229-7yoilsho	2955	55	28	28	CD
cord-006229-7yoilsho	2955	56	)	)	-RRB-
cord-006229-7yoilsho	2955	57	:	:	:
cord-006229-7yoilsho	2955	58	TiO	tio	NN
cord-006229-7yoilsho	2955	59	2	2	CD
cord-006229-7yoilsho	2955	60	(	(	-LRB-
cord-006229-7yoilsho	2955	61	rutile	rutile	NN
cord-006229-7yoilsho	2955	62	,	,	,
cord-006229-7yoilsho	2955	63	micro	micro	NNP
cord-006229-7yoilsho	2955	64	)	)	-RRB-
cord-006229-7yoilsho	2955	65	,	,	,
cord-006229-7yoilsho	2955	66	TiO	tio	NN
cord-006229-7yoilsho	2955	67	2	2	CD
cord-006229-7yoilsho	2956	1	(	(	-LRB-
cord-006229-7yoilsho	2956	2	anatase	anatase	NNP
cord-006229-7yoilsho	2956	3	,	,	,
cord-006229-7yoilsho	2956	4	nano	nano	NNP
cord-006229-7yoilsho	2956	5	)	)	-RRB-
cord-006229-7yoilsho	2956	6	,	,	.
cord-006229-7yoilsho	2957	1	Eu	Eu	NNP
cord-006229-7yoilsho	2957	2	2	2	CD
cord-006229-7yoilsho	2957	3	O	o	NN
cord-006229-7yoilsho	2957	4	3	3	CD
cord-006229-7yoilsho	2958	1	(	(	-LRB-
cord-006229-7yoilsho	2958	2	micro	micro	JJ
cord-006229-7yoilsho	2958	3	-	-	JJ
cord-006229-7yoilsho	2958	4	nano	nano	JJ
cord-006229-7yoilsho	2958	5	mixed	mixed	JJ
cord-006229-7yoilsho	2958	6	)	)	-RRB-
cord-006229-7yoilsho	2958	7	,	,	.
cord-006229-7yoilsho	2959	1	BaSO	BaSO	NNP
cord-006229-7yoilsho	2959	2	4	4	CD
cord-006229-7yoilsho	2960	1	(	(	-LRB-
cord-006229-7yoilsho	2960	2	micro	micro	NNP
cord-006229-7yoilsho	2960	3	)	)	-RRB-
cord-006229-7yoilsho	2960	4	,	,	,
cord-006229-7yoilsho	2960	5	ZrO	ZrO	NNP
cord-006229-7yoilsho	2960	6	2	2	CD
cord-006229-7yoilsho	2960	7	(	(	-LRB-
cord-006229-7yoilsho	2960	8	micro	micro	NNP
cord-006229-7yoilsho	2960	9	)	)	-RRB-
cord-006229-7yoilsho	2960	10	and	and	CC
cord-006229-7yoilsho	2960	11	amorphous	amorphous	JJ
cord-006229-7yoilsho	2960	12	SiO	SiO	NNP
cord-006229-7yoilsho	2960	13	2	2	CD
cord-006229-7yoilsho	2960	14	(	(	-LRB-
cord-006229-7yoilsho	2960	15	nano	nano	NNP
cord-006229-7yoilsho	2960	16	)	)	-RRB-
cord-006229-7yoilsho	2960	17	.	.	.
cord-006229-7yoilsho	2961	1	Two	two	CD
cord-006229-7yoilsho	2961	2	doses	dose	NNS
cord-006229-7yoilsho	2961	3	of	of	IN
cord-006229-7yoilsho	2961	4	0.5	0.5	CD
cord-006229-7yoilsho	2961	5	and	and	CC
cord-006229-7yoilsho	2961	6	1.5	1.5	CD
cord-006229-7yoilsho	2961	7	µl	µl	IN
cord-006229-7yoilsho	2961	8	per	per	IN
cord-006229-7yoilsho	2961	9	rat	rat	NN
cord-006229-7yoilsho	2961	10	were	be	VBD
cord-006229-7yoilsho	2961	11	administered	administer	VBN
cord-006229-7yoilsho	2961	12	to	to	IN
cord-006229-7yoilsho	2961	13	Wistar	Wistar	NNP
cord-006229-7yoilsho	2961	14	rats	rat	NNS
cord-006229-7yoilsho	2961	15	;	;	:
cord-006229-7yoilsho	2961	16	these	these	DT
cord-006229-7yoilsho	2961	17	volume	volume	NN
cord-006229-7yoilsho	2961	18	doses	dose	NNS
cord-006229-7yoilsho	2961	19	resulted	result	VBD
cord-006229-7yoilsho	2961	20	in	in	IN
cord-006229-7yoilsho	2961	21	a	a	DT
cord-006229-7yoilsho	2961	22	non	non	JJ
cord-006229-7yoilsho	2961	23	-	-	JJ
cord-006229-7yoilsho	2961	24	overload	overload	JJ
cord-006229-7yoilsho	2961	25	and	and	CC
cord-006229-7yoilsho	2961	26	moderate	moderate	JJ
cord-006229-7yoilsho	2961	27	overload	overload	NN
cord-006229-7yoilsho	2961	28	of	of	IN
cord-006229-7yoilsho	2961	29	lungs	lung	NNS
cord-006229-7yoilsho	2961	30	,	,	,
cord-006229-7yoilsho	2961	31	respectively	respectively	RB
cord-006229-7yoilsho	2961	32	.	.	.
cord-006229-7yoilsho	2962	1	-The	-The	:
cord-006229-7yoilsho	2962	2	differential	differential	JJ
cord-006229-7yoilsho	2962	3	cell	cell	NN
cord-006229-7yoilsho	2962	4	count	count	NN
cord-006229-7yoilsho	2962	5	showed	show	VBD
cord-006229-7yoilsho	2962	6	only	only	RB
cord-006229-7yoilsho	2962	7	slight	slight	JJ
cord-006229-7yoilsho	2962	8	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	2962	9	cell	cell	NN
cord-006229-7yoilsho	2962	10	levels	level	NNS
cord-006229-7yoilsho	2962	11	after	after	IN
cord-006229-7yoilsho	2962	12	treatment	treatment	NN
cord-006229-7yoilsho	2962	13	with	with	IN
cord-006229-7yoilsho	2962	14	TiO	tio	NN
cord-006229-7yoilsho	2962	15	2	2	CD
cord-006229-7yoilsho	2962	16	(	(	-LRB-
cord-006229-7yoilsho	2962	17	rutile	rutile	NN
cord-006229-7yoilsho	2962	18	)	)	-RRB-
cord-006229-7yoilsho	2962	19	and	and	CC
cord-006229-7yoilsho	2962	20	BaSO	BaSO	NNP
cord-006229-7yoilsho	2962	21	4	4	CD
cord-006229-7yoilsho	2962	22	(	(	-LRB-
cord-006229-7yoilsho	2962	23	PMN	pmn	NN
cord-006229-7yoilsho	2962	24	<	<	XX
cord-006229-7yoilsho	2962	25	5	5	CD
cord-006229-7yoilsho	2962	26	%	%	NN
cord-006229-7yoilsho	2962	27	after	after	IN
cord-006229-7yoilsho	2962	28	3	3	CD
cord-006229-7yoilsho	2962	29	days	day	NNS
cord-006229-7yoilsho	2962	30	in	in	IN
cord-006229-7yoilsho	2962	31	the	the	DT
cord-006229-7yoilsho	2962	32	low	low	JJ
cord-006229-7yoilsho	2962	33	dose	dose	NN
cord-006229-7yoilsho	2962	34	group	group	NN
cord-006229-7yoilsho	2962	35	;	;	:
cord-006229-7yoilsho	2962	36	<	<	XX
cord-006229-7yoilsho	2962	37	15	15	CD
cord-006229-7yoilsho	2962	38	%	%	NN
cord-006229-7yoilsho	2962	39	in	in	IN
cord-006229-7yoilsho	2962	40	the	the	DT
cord-006229-7yoilsho	2962	41	high	high	JJ
cord-006229-7yoilsho	2962	42	dose	dose	NN
cord-006229-7yoilsho	2962	43	group	group	NN
cord-006229-7yoilsho	2962	44	;	;	:
cord-006229-7yoilsho	2962	45	full	full	JJ
cord-006229-7yoilsho	2962	46	recovery	recovery	NN
cord-006229-7yoilsho	2962	47	after	after	IN
cord-006229-7yoilsho	2962	48	28	28	CD
cord-006229-7yoilsho	2962	49	days	day	NNS
cord-006229-7yoilsho	2962	50	)	)	-RRB-
cord-006229-7yoilsho	2962	51	.	.	.
cord-006229-7yoilsho	2963	1	In	in	IN
cord-006229-7yoilsho	2963	2	contrast	contrast	NN
cord-006229-7yoilsho	2963	3	,	,	,
cord-006229-7yoilsho	2963	4	the	the	DT
cord-006229-7yoilsho	2963	5	TiO	tio	NN
cord-006229-7yoilsho	2963	6	2	2	CD
cord-006229-7yoilsho	2963	7	(	(	-LRB-
cord-006229-7yoilsho	2963	8	anatase	anatase	NNP
cord-006229-7yoilsho	2963	9	)	)	-RRB-
cord-006229-7yoilsho	2963	10	showed	show	VBD
cord-006229-7yoilsho	2963	11	a	a	DT
cord-006229-7yoilsho	2963	12	stronger	strong	JJR
cord-006229-7yoilsho	2963	13	response	response	NN
cord-006229-7yoilsho	2963	14	(	(	-LRB-
cord-006229-7yoilsho	2963	15	PMN	pmn	NN
cord-006229-7yoilsho	2963	16	>	>	XX
cord-006229-7yoilsho	2963	17	30	30	CD
cord-006229-7yoilsho	2963	18	%	%	NN
cord-006229-7yoilsho	2963	19	after	after	IN
cord-006229-7yoilsho	2963	20	3	3	CD
cord-006229-7yoilsho	2963	21	and	and	CC
cord-006229-7yoilsho	2963	22	28	28	CD
cord-006229-7yoilsho	2963	23	days	day	NNS
cord-006229-7yoilsho	2963	24	)	)	-RRB-
cord-006229-7yoilsho	2963	25	.	.	.
cord-006229-7yoilsho	2964	1	The	the	DT
cord-006229-7yoilsho	2964	2	rare	rare	JJ
cord-006229-7yoilsho	2964	3	earth	earth	NN
cord-006229-7yoilsho	2964	4	Eu	Eu	NNP
cord-006229-7yoilsho	2964	5	2	2	CD
cord-006229-7yoilsho	2964	6	O	o	NN
cord-006229-7yoilsho	2964	7	3	3	CD
cord-006229-7yoilsho	2964	8	(	(	-LRB-
cord-006229-7yoilsho	2964	9	micro	micro	JJ
cord-006229-7yoilsho	2964	10	-	-	JJ
cord-006229-7yoilsho	2964	11	nano	nano	JJ
cord-006229-7yoilsho	2964	12	)	)	-RRB-
cord-006229-7yoilsho	2964	13	dust	dust	NN
cord-006229-7yoilsho	2964	14	showed	show	VBD
cord-006229-7yoilsho	2964	15	the	the	DT
cord-006229-7yoilsho	2964	16	strongest	strong	JJS
cord-006229-7yoilsho	2964	17	effect	effect	NN
cord-006229-7yoilsho	2964	18	(	(	-LRB-
cord-006229-7yoilsho	2964	19	approx	approx	NN
cord-006229-7yoilsho	2964	20	.	.	.
cord-006229-7yoilsho	2964	21	40	40	CD
cord-006229-7yoilsho	2964	22	%	%	NN
cord-006229-7yoilsho	2964	23	PMN	PMN	NNP
cord-006229-7yoilsho	2964	24	after	after	IN
cord-006229-7yoilsho	2964	25	3	3	CD
cord-006229-7yoilsho	2964	26	and	and	CC
cord-006229-7yoilsho	2964	27	28	28	CD
cord-006229-7yoilsho	2964	28	days	day	NNS
cord-006229-7yoilsho	2964	29	)	)	-RRB-
cord-006229-7yoilsho	2964	30	including	include	VBG
cord-006229-7yoilsho	2964	31	a	a	DT
cord-006229-7yoilsho	2964	32	red	red	JJ
cord-006229-7yoilsho	2964	33	-	-	HYPH
cord-006229-7yoilsho	2964	34	coloured	coloured	JJ
cord-006229-7yoilsho	2964	35	lung	lung	NN
cord-006229-7yoilsho	2964	36	lavage	lavage	NN
cord-006229-7yoilsho	2964	37	fluid	fluid	NN
cord-006229-7yoilsho	2964	38	.	.	.
cord-006229-7yoilsho	2965	1	µ-ZrO	µ-ZrO	NNP
cord-006229-7yoilsho	2965	2	2	2	CD
cord-006229-7yoilsho	2965	3	and	and	CC
cord-006229-7yoilsho	2965	4	amorphous	amorphous	JJ
cord-006229-7yoilsho	2965	5	SiO	SiO	NNP
cord-006229-7yoilsho	2965	6	2	2	CD
cord-006229-7yoilsho	2965	7	showed	show	VBD
cord-006229-7yoilsho	2965	8	a	a	DT
cord-006229-7yoilsho	2965	9	strong	strong	JJ
cord-006229-7yoilsho	2965	10	acute	acute	JJ
cord-006229-7yoilsho	2965	11	response	response	NN
cord-006229-7yoilsho	2965	12	after	after	IN
cord-006229-7yoilsho	2965	13	3	3	CD
cord-006229-7yoilsho	2965	14	days	day	NNS
cord-006229-7yoilsho	2965	15	,	,	,
cord-006229-7yoilsho	2965	16	however	however	RB
cord-006229-7yoilsho	2965	17	,	,	,
cord-006229-7yoilsho	2965	18	mostly	mostly	RB
cord-006229-7yoilsho	2965	19	complete	complete	JJ
cord-006229-7yoilsho	2965	20	recovery	recovery	NN
cord-006229-7yoilsho	2965	21	after	after	IN
cord-006229-7yoilsho	2965	22	28	28	CD
cord-006229-7yoilsho	2965	23	days	day	NNS
cord-006229-7yoilsho	2965	24	.	.	.
cord-006229-7yoilsho	2966	1	The	the	DT
cord-006229-7yoilsho	2966	2	low	low	JJ
cord-006229-7yoilsho	2966	3	solubility	solubility	NN
cord-006229-7yoilsho	2966	4	criterion	criterion	NN
cord-006229-7yoilsho	2966	5	was	be	VBD
cord-006229-7yoilsho	2966	6	met	meet	VBN
cord-006229-7yoilsho	2966	7	by	by	IN
cord-006229-7yoilsho	2966	8	the	the	DT
cord-006229-7yoilsho	2966	9	following	follow	VBG
cord-006229-7yoilsho	2966	10	dusts	dust	NNS
cord-006229-7yoilsho	2966	11	:	:	:
cord-006229-7yoilsho	2966	12	TiO	tio	NN
cord-006229-7yoilsho	2966	13	2	2	CD
cord-006229-7yoilsho	2966	14	(	(	-LRB-
cord-006229-7yoilsho	2966	15	both	both	DT
cord-006229-7yoilsho	2966	16	)	)	-RRB-
cord-006229-7yoilsho	2966	17	and	and	CC
cord-006229-7yoilsho	2966	18	ZrO	zro	JJ
cord-006229-7yoilsho	2966	19	2	2	CD
cord-006229-7yoilsho	2966	20	.	.	.
cord-006229-7yoilsho	2967	1	-Similar	-similar	JJ
cord-006229-7yoilsho	2967	2	volumetric	volumetric	JJ
cord-006229-7yoilsho	2967	3	lung	lung	NN
cord-006229-7yoilsho	2967	4	burdens	burden	NNS
cord-006229-7yoilsho	2967	5	were	be	VBD
cord-006229-7yoilsho	2967	6	deposited	deposit	VBN
cord-006229-7yoilsho	2967	7	in	in	IN
cord-006229-7yoilsho	2967	8	a	a	DT
cord-006229-7yoilsho	2967	9	parallel	parallel	JJ
cord-006229-7yoilsho	2967	10	validation	validation	NN
cord-006229-7yoilsho	2967	11	experiment	experiment	NN
cord-006229-7yoilsho	2967	12	(	(	-LRB-
cord-006229-7yoilsho	2967	13	14-day	14-day	CD
cord-006229-7yoilsho	2967	14	subacute	subacute	JJ
cord-006229-7yoilsho	2967	15	inhalations	inhalation	NNS
cord-006229-7yoilsho	2967	16	)	)	-RRB-
cord-006229-7yoilsho	2967	17	.	.	.
cord-006229-7yoilsho	2968	1	Overall	overall	RB
cord-006229-7yoilsho	2968	2	the	the	DT
cord-006229-7yoilsho	2968	3	physiological	physiological	JJ
cord-006229-7yoilsho	2968	4	inhalation	inhalation	NN
cord-006229-7yoilsho	2968	5	route	route	NN
cord-006229-7yoilsho	2968	6	confirmed	confirm	VBD
cord-006229-7yoilsho	2968	7	the	the	DT
cord-006229-7yoilsho	2968	8	results	result	NNS
cord-006229-7yoilsho	2968	9	obtained	obtain	VBN
cord-006229-7yoilsho	2968	10	in	in	IN
cord-006229-7yoilsho	2968	11	the	the	DT
cord-006229-7yoilsho	2968	12	instillation	instillation	NN
cord-006229-7yoilsho	2968	13	study	study	NN
cord-006229-7yoilsho	2968	14	,	,	,
cord-006229-7yoilsho	2968	15	thus	thus	RB
cord-006229-7yoilsho	2968	16	suggesting	suggest	VBG
cord-006229-7yoilsho	2968	17	the	the	DT
cord-006229-7yoilsho	2968	18	applicability	applicability	NN
cord-006229-7yoilsho	2968	19	of	of	IN
cord-006229-7yoilsho	2968	20	the	the	DT
cord-006229-7yoilsho	2968	21	latter	latter	JJ
cord-006229-7yoilsho	2968	22	as	as	IN
cord-006229-7yoilsho	2968	23	a	a	DT
cord-006229-7yoilsho	2968	24	tool	tool	NN
cord-006229-7yoilsho	2968	25	for	for	IN
cord-006229-7yoilsho	2968	26	identification	identification	NN
cord-006229-7yoilsho	2968	27	for	for	IN
cord-006229-7yoilsho	2968	28	GBS	GBS	NNP
cord-006229-7yoilsho	2968	29	dusts	dust	NNS
cord-006229-7yoilsho	2968	30	.	.	.
cord-006229-7yoilsho	2969	1	However	however	RB
cord-006229-7yoilsho	2969	2	,	,	,
cord-006229-7yoilsho	2969	3	for	for	IN
cord-006229-7yoilsho	2969	4	nanoscaled	nanoscaled	JJ
cord-006229-7yoilsho	2969	5	dusts	dust	VBZ
cord-006229-7yoilsho	2969	6	an	an	DT
cord-006229-7yoilsho	2969	7	individual	individual	JJ
cord-006229-7yoilsho	2969	8	toxicological	toxicological	JJ
cord-006229-7yoilsho	2969	9	characterization	characterization	NN
cord-006229-7yoilsho	2969	10	seems	seem	VBZ
cord-006229-7yoilsho	2969	11	to	to	TO
cord-006229-7yoilsho	2969	12	be	be	VB
cord-006229-7yoilsho	2969	13	adequate	adequate	JJ
cord-006229-7yoilsho	2969	14	.	.	.
cord-006229-7yoilsho	2970	1	Polycyclic	polycyclic	JJ
cord-006229-7yoilsho	2970	2	aromatic	aromatic	JJ
cord-006229-7yoilsho	2970	3	hydrocarbons	hydrocarbon	NNS
cord-006229-7yoilsho	2970	4	(	(	-LRB-
cord-006229-7yoilsho	2970	5	PAH	PAH	NNP
cord-006229-7yoilsho	2970	6	)	)	-RRB-
cord-006229-7yoilsho	2970	7	represent	represent	VBP
cord-006229-7yoilsho	2970	8	a	a	DT
cord-006229-7yoilsho	2970	9	complex	complex	JJ
cord-006229-7yoilsho	2970	10	mixture	mixture	NN
cord-006229-7yoilsho	2970	11	of	of	IN
cord-006229-7yoilsho	2970	12	compounds	compound	NNS
cord-006229-7yoilsho	2970	13	and	and	CC
cord-006229-7yoilsho	2970	14	occur	occur	VBP
cord-006229-7yoilsho	2970	15	in	in	IN
cord-006229-7yoilsho	2970	16	considerable	considerable	JJ
cord-006229-7yoilsho	2970	17	amounts	amount	NNS
cord-006229-7yoilsho	2970	18	as	as	IN
cord-006229-7yoilsho	2970	19	contaminants	contaminant	NNS
cord-006229-7yoilsho	2970	20	in	in	IN
cord-006229-7yoilsho	2970	21	the	the	DT
cord-006229-7yoilsho	2970	22	environment	environment	NN
cord-006229-7yoilsho	2970	23	and	and	CC
cord-006229-7yoilsho	2970	24	food	food	NN
cord-006229-7yoilsho	2970	25	.	.	.
cord-006229-7yoilsho	2971	1	Some	some	DT
cord-006229-7yoilsho	2971	2	PAH	PAH	NNP
cord-006229-7yoilsho	2971	3	have	have	VBP
cord-006229-7yoilsho	2971	4	been	be	VBN
cord-006229-7yoilsho	2971	5	demonstrated	demonstrate	VBN
cord-006229-7yoilsho	2971	6	to	to	TO
cord-006229-7yoilsho	2971	7	be	be	VB
cord-006229-7yoilsho	2971	8	carcinogenic	carcinogenic	JJ
cord-006229-7yoilsho	2971	9	and	and	CC
cord-006229-7yoilsho	2971	10	mutagenic	mutagenic	JJ
cord-006229-7yoilsho	2971	11	.	.	.
cord-006229-7yoilsho	2972	1	Benzo[a]pyrene	Benzo[a]pyrene	NNP
cord-006229-7yoilsho	2972	2	(	(	-LRB-
cord-006229-7yoilsho	2972	3	BP	BP	NNP
cord-006229-7yoilsho	2972	4	)	)	-RRB-
cord-006229-7yoilsho	2972	5	,	,	,
cord-006229-7yoilsho	2972	6	the	the	DT
cord-006229-7yoilsho	2972	7	most	most	RBS
cord-006229-7yoilsho	2972	8	known	know	VBN
cord-006229-7yoilsho	2972	9	and	and	CC
cord-006229-7yoilsho	2972	10	studied	study	VBN
cord-006229-7yoilsho	2972	11	member	member	NN
cord-006229-7yoilsho	2972	12	of	of	IN
cord-006229-7yoilsho	2972	13	the	the	DT
cord-006229-7yoilsho	2972	14	potent	potent	JJ
cord-006229-7yoilsho	2972	15	carcinogenic	carcinogenic	JJ
cord-006229-7yoilsho	2972	16	PAH	PAH	NNP
cord-006229-7yoilsho	2972	17	,	,	,
cord-006229-7yoilsho	2972	18	is	be	VBZ
cord-006229-7yoilsho	2972	19	classified	classify	VBN
cord-006229-7yoilsho	2972	20	by	by	IN
cord-006229-7yoilsho	2972	21	IARC	IARC	NNP
cord-006229-7yoilsho	2972	22	as	as	IN
cord-006229-7yoilsho	2972	23	group	group	NN
cord-006229-7yoilsho	2972	24	1	1	CD
cord-006229-7yoilsho	2972	25	carcinogen	carcinogen	NN
cord-006229-7yoilsho	2972	26	and	and	CC
cord-006229-7yoilsho	2972	27	is	be	VBZ
cord-006229-7yoilsho	2972	28	present	present	JJ
cord-006229-7yoilsho	2972	29	in	in	IN
cord-006229-7yoilsho	2972	30	a	a	DT
cord-006229-7yoilsho	2972	31	wide	wide	JJ
cord-006229-7yoilsho	2972	32	variety	variety	NN
cord-006229-7yoilsho	2972	33	of	of	IN
cord-006229-7yoilsho	2972	34	food	food	NN
cord-006229-7yoilsho	2972	35	items	item	NNS
cord-006229-7yoilsho	2972	36	.	.	.
cord-006229-7yoilsho	2973	1	However	however	RB
cord-006229-7yoilsho	2973	2	,	,	,
cord-006229-7yoilsho	2973	3	other	other	JJ
cord-006229-7yoilsho	2973	4	non	non	JJ
cord-006229-7yoilsho	2973	5	-	-	JJ
cord-006229-7yoilsho	2973	6	carcinogenic	carcinogenic	JJ
cord-006229-7yoilsho	2973	7	PAH	PAH	NNP
cord-006229-7yoilsho	2973	8	such	such	JJ
cord-006229-7yoilsho	2973	9	as	as	IN
cord-006229-7yoilsho	2973	10	pyrene	pyrene	NNP
cord-006229-7yoilsho	2973	11	(	(	-LRB-
cord-006229-7yoilsho	2973	12	PYR	PYR	NNP
cord-006229-7yoilsho	2973	13	)	)	-RRB-
cord-006229-7yoilsho	2973	14	and	and	CC
cord-006229-7yoilsho	2973	15	fluoranthene	fluoranthene	NNP
cord-006229-7yoilsho	2973	16	(	(	-LRB-
cord-006229-7yoilsho	2973	17	FA	FA	NNP
cord-006229-7yoilsho	2973	18	)	)	-RRB-
cord-006229-7yoilsho	2973	19	are	be	VBP
cord-006229-7yoilsho	2973	20	also	also	RB
cord-006229-7yoilsho	2973	21	found	find	VBN
cord-006229-7yoilsho	2973	22	in	in	IN
cord-006229-7yoilsho	2973	23	substantial	substantial	JJ
cord-006229-7yoilsho	2973	24	amounts	amount	NNS
cord-006229-7yoilsho	2973	25	in	in	IN
cord-006229-7yoilsho	2973	26	the	the	DT
cord-006229-7yoilsho	2973	27	diet	diet	NN
cord-006229-7yoilsho	2973	28	and	and	CC
cord-006229-7yoilsho	2973	29	are	be	VBP
cord-006229-7yoilsho	2973	30	strongly	strongly	RB
cord-006229-7yoilsho	2973	31	suspicious	suspicious	JJ
cord-006229-7yoilsho	2973	32	to	to	TO
cord-006229-7yoilsho	2973	33	cause	cause	VB
cord-006229-7yoilsho	2973	34	interactive	interactive	JJ
cord-006229-7yoilsho	2973	35	effects	effect	NNS
cord-006229-7yoilsho	2973	36	.	.	.
cord-006229-7yoilsho	2974	1	Reporter	reporter	NN
cord-006229-7yoilsho	2974	2	gene	gene	NN
cord-006229-7yoilsho	2974	3	assays	assay	NNS
cord-006229-7yoilsho	2974	4	were	be	VBD
cord-006229-7yoilsho	2974	5	used	use	VBN
cord-006229-7yoilsho	2974	6	for	for	IN
cord-006229-7yoilsho	2974	7	analyzing	analyze	VBG
cord-006229-7yoilsho	2974	8	interactive	interactive	JJ
cord-006229-7yoilsho	2974	9	effects	effect	NNS
cord-006229-7yoilsho	2974	10	of	of	IN
cord-006229-7yoilsho	2974	11	a	a	DT
cord-006229-7yoilsho	2974	12	ternary	ternary	JJ
cord-006229-7yoilsho	2974	13	mixture	mixture	NN
cord-006229-7yoilsho	2974	14	including	include	VBG
cord-006229-7yoilsho	2974	15	BP	BP	NNP
cord-006229-7yoilsho	2974	16	,	,	,
cord-006229-7yoilsho	2974	17	PYR	PYR	NNP
cord-006229-7yoilsho	2974	18	and	and	CC
cord-006229-7yoilsho	2974	19	FA	FA	NNP
cord-006229-7yoilsho	2974	20	in	in	IN
cord-006229-7yoilsho	2974	21	relative	relative	JJ
cord-006229-7yoilsho	2974	22	proportions	proportion	NNS
cord-006229-7yoilsho	2974	23	occurring	occur	VBG
cord-006229-7yoilsho	2974	24	in	in	IN
cord-006229-7yoilsho	2974	25	food	food	NN
cord-006229-7yoilsho	2974	26	on	on	IN
cord-006229-7yoilsho	2974	27	the	the	DT
cord-006229-7yoilsho	2974	28	nuclear	nuclear	JJ
cord-006229-7yoilsho	2974	29	receptors	receptor	NNS
cord-006229-7yoilsho	2974	30	aryl	aryl	NN
cord-006229-7yoilsho	2974	31	hydrocarbon	hydrocarbon	NN
cord-006229-7yoilsho	2974	32	receptor	receptor	NN
cord-006229-7yoilsho	2974	33	(	(	-LRB-
cord-006229-7yoilsho	2974	34	AhR	AhR	NNP
cord-006229-7yoilsho	2974	35	)	)	-RRB-
cord-006229-7yoilsho	2974	36	and	and	CC
cord-006229-7yoilsho	2974	37	constitutive	constitutive	JJ
cord-006229-7yoilsho	2974	38	androstane	androstane	NN
cord-006229-7yoilsho	2974	39	receptor	receptor	NN
cord-006229-7yoilsho	2974	40	(	(	-LRB-
cord-006229-7yoilsho	2974	41	CAR	car	NN
cord-006229-7yoilsho	2974	42	)	)	-RRB-
cord-006229-7yoilsho	2974	43	.	.	.
cord-006229-7yoilsho	2975	1	The	the	DT
cord-006229-7yoilsho	2975	2	observed	observed	JJ
cord-006229-7yoilsho	2975	3	activations	activation	NNS
cord-006229-7yoilsho	2975	4	were	be	VBD
cord-006229-7yoilsho	2975	5	verified	verify	VBN
cord-006229-7yoilsho	2975	6	at	at	IN
cord-006229-7yoilsho	2975	7	the	the	DT
cord-006229-7yoilsho	2975	8	gene	gene	NN
cord-006229-7yoilsho	2975	9	expression	expression	NN
cord-006229-7yoilsho	2975	10	level	level	NN
cord-006229-7yoilsho	2975	11	in	in	IN
cord-006229-7yoilsho	2975	12	the	the	DT
cord-006229-7yoilsho	2975	13	human	human	JJ
cord-006229-7yoilsho	2975	14	hepatoma	hepatoma	NNP
cord-006229-7yoilsho	2975	15	cell	cell	NN
cord-006229-7yoilsho	2975	16	line	line	NN
cord-006229-7yoilsho	2975	17	HepaRG	HepaRG	NNP
cord-006229-7yoilsho	2975	18	.	.	.
cord-006229-7yoilsho	2976	1	Beside	beside	IN
cord-006229-7yoilsho	2976	2	the	the	DT
cord-006229-7yoilsho	2976	3	well	well	RB
cord-006229-7yoilsho	2976	4	characterized	characterize	VBN
cord-006229-7yoilsho	2976	5	ligand	ligand	NN
cord-006229-7yoilsho	2976	6	BP	BP	NNP
cord-006229-7yoilsho	2976	7	,	,	,
cord-006229-7yoilsho	2976	8	25	25	CD
cord-006229-7yoilsho	2976	9	µM	µm	CD
cord-006229-7yoilsho	2976	10	of	of	IN
cord-006229-7yoilsho	2976	11	PYR	PYR	NNP
cord-006229-7yoilsho	2976	12	and	and	CC
cord-006229-7yoilsho	2976	13	20	20	CD
cord-006229-7yoilsho	2976	14	µM	µm	NN
cord-006229-7yoilsho	2976	15	FA	FA	NNP
cord-006229-7yoilsho	2976	16	also	also	RB
cord-006229-7yoilsho	2976	17	activated	activate	VBD
cord-006229-7yoilsho	2976	18	the	the	DT
cord-006229-7yoilsho	2976	19	AhR	ahr	NN
cord-006229-7yoilsho	2976	20	,	,	,
cord-006229-7yoilsho	2976	21	even	even	RB
cord-006229-7yoilsho	2976	22	though	though	IN
cord-006229-7yoilsho	2976	23	to	to	IN
cord-006229-7yoilsho	2976	24	a	a	DT
cord-006229-7yoilsho	2976	25	much	much	RB
cord-006229-7yoilsho	2976	26	lesser	less	JJR
cord-006229-7yoilsho	2976	27	extent	extent	NN
cord-006229-7yoilsho	2976	28	.	.	.
cord-006229-7yoilsho	2977	1	No	no	DT
cord-006229-7yoilsho	2977	2	significant	significant	JJ
cord-006229-7yoilsho	2977	3	higher	high	JJR
cord-006229-7yoilsho	2977	4	activation	activation	NN
cord-006229-7yoilsho	2977	5	over	over	IN
cord-006229-7yoilsho	2977	6	the	the	DT
cord-006229-7yoilsho	2977	7	level	level	NN
cord-006229-7yoilsho	2977	8	of	of	IN
cord-006229-7yoilsho	2977	9	BP	BP	NNP
cord-006229-7yoilsho	2977	10	alone	alone	RB
cord-006229-7yoilsho	2977	11	was	be	VBD
cord-006229-7yoilsho	2977	12	reached	reach	VBN
cord-006229-7yoilsho	2977	13	when	when	WRB
cord-006229-7yoilsho	2977	14	testing	test	VBG
cord-006229-7yoilsho	2977	15	different	different	JJ
cord-006229-7yoilsho	2977	16	PAH	PAH	NNP
cord-006229-7yoilsho	2977	17	mixtures	mixture	NNS
cord-006229-7yoilsho	2977	18	.	.	.
cord-006229-7yoilsho	2978	1	However	however	RB
cord-006229-7yoilsho	2978	2	,	,	,
cord-006229-7yoilsho	2978	3	in	in	IN
cord-006229-7yoilsho	2978	4	HepaRG	HepaRG	NNP
cord-006229-7yoilsho	2978	5	cells	cell	VBZ
cord-006229-7yoilsho	2978	6	the	the	DT
cord-006229-7yoilsho	2978	7	analysis	analysis	NN
cord-006229-7yoilsho	2978	8	of	of	IN
cord-006229-7yoilsho	2978	9	CYP1A1	CYP1A1	NNP
cord-006229-7yoilsho	2978	10	gene	gene	NN
cord-006229-7yoilsho	2978	11	expression	expression	NN
cord-006229-7yoilsho	2978	12	as	as	IN
cord-006229-7yoilsho	2978	13	a	a	DT
cord-006229-7yoilsho	2978	14	model	model	NN
cord-006229-7yoilsho	2978	15	target	target	NN
cord-006229-7yoilsho	2978	16	gene	gene	NN
cord-006229-7yoilsho	2978	17	of	of	IN
cord-006229-7yoilsho	2978	18	AhR	AhR	NNP
cord-006229-7yoilsho	2978	19	showed	show	VBD
cord-006229-7yoilsho	2978	20	synergistic	synergistic	JJ
cord-006229-7yoilsho	2978	21	effects	effect	NNS
cord-006229-7yoilsho	2978	22	after	after	IN
cord-006229-7yoilsho	2978	23	PAH	PAH	NNP
cord-006229-7yoilsho	2978	24	co	co	NN
cord-006229-7yoilsho	2978	25	-	-	NN
cord-006229-7yoilsho	2978	26	exposure	exposure	NN
cord-006229-7yoilsho	2978	27	.	.	.
cord-006229-7yoilsho	2979	1	In	in	IN
cord-006229-7yoilsho	2979	2	addition	addition	NN
cord-006229-7yoilsho	2979	3	,	,	,
cord-006229-7yoilsho	2979	4	the	the	DT
cord-006229-7yoilsho	2979	5	activation	activation	NN
cord-006229-7yoilsho	2979	6	of	of	IN
cord-006229-7yoilsho	2979	7	human	human	JJ
cord-006229-7yoilsho	2979	8	CAR	car	NN
cord-006229-7yoilsho	2979	9	was	be	VBD
cord-006229-7yoilsho	2979	10	analyzed	analyze	VBN
cord-006229-7yoilsho	2979	11	.	.	.
cord-006229-7yoilsho	2980	1	PYR	PYR	NNP
cord-006229-7yoilsho	2980	2	and	and	CC
cord-006229-7yoilsho	2980	3	FA	FA	NNP
cord-006229-7yoilsho	2980	4	are	be	VBP
cord-006229-7yoilsho	2980	5	each	each	DT
cord-006229-7yoilsho	2980	6	strong	strong	JJ
cord-006229-7yoilsho	2980	7	agonists	agonist	NNS
cord-006229-7yoilsho	2980	8	,	,	,
cord-006229-7yoilsho	2980	9	whereas	whereas	IN
cord-006229-7yoilsho	2980	10	BP	BP	NNP
cord-006229-7yoilsho	2980	11	was	be	VBD
cord-006229-7yoilsho	2980	12	less	less	RBR
cord-006229-7yoilsho	2980	13	potent	potent	JJ
cord-006229-7yoilsho	2980	14	.	.	.
cord-006229-7yoilsho	2981	1	For	for	IN
cord-006229-7yoilsho	2981	2	the	the	DT
cord-006229-7yoilsho	2981	3	ternary	ternary	JJ
cord-006229-7yoilsho	2981	4	PAH	PAH	NNP
cord-006229-7yoilsho	2981	5	mixture	mixture	NN
cord-006229-7yoilsho	2981	6	with	with	IN
cord-006229-7yoilsho	2981	7	BP	BP	NNP
cord-006229-7yoilsho	2981	8	a	a	DT
cord-006229-7yoilsho	2981	9	strong	strong	JJ
cord-006229-7yoilsho	2981	10	decrease	decrease	NN
cord-006229-7yoilsho	2981	11	of	of	IN
cord-006229-7yoilsho	2981	12	the	the	DT
cord-006229-7yoilsho	2981	13	induction	induction	NN
cord-006229-7yoilsho	2981	14	was	be	VBD
cord-006229-7yoilsho	2981	15	observed	observe	VBN
cord-006229-7yoilsho	2981	16	.	.	.
cord-006229-7yoilsho	2982	1	This	this	DT
cord-006229-7yoilsho	2982	2	inhibiting	inhibit	VBG
cord-006229-7yoilsho	2982	3	effect	effect	NN
cord-006229-7yoilsho	2982	4	was	be	VBD
cord-006229-7yoilsho	2982	5	verified	verify	VBN
cord-006229-7yoilsho	2982	6	at	at	IN
cord-006229-7yoilsho	2982	7	the	the	DT
cord-006229-7yoilsho	2982	8	mRNA	mRNA	NNP
cord-006229-7yoilsho	2982	9	level	level	NN
cord-006229-7yoilsho	2982	10	using	use	VBG
cord-006229-7yoilsho	2982	11	the	the	DT
cord-006229-7yoilsho	2982	12	model	model	NN
cord-006229-7yoilsho	2982	13	CAR	CAR	NNP
cord-006229-7yoilsho	2982	14	target	target	NN
cord-006229-7yoilsho	2982	15	gene	gene	NN
cord-006229-7yoilsho	2982	16	CYP2B6	cyp2b6	XX
cord-006229-7yoilsho	2982	17	in	in	IN
cord-006229-7yoilsho	2982	18	HepaRG	HepaRG	NNP
cord-006229-7yoilsho	2982	19	cells	cell	NNS
cord-006229-7yoilsho	2982	20	.	.	.
cord-006229-7yoilsho	2983	1	In	in	IN
cord-006229-7yoilsho	2983	2	conclusion	conclusion	NN
cord-006229-7yoilsho	2983	3	,	,	,
cord-006229-7yoilsho	2983	4	really	really	RB
cord-006229-7yoilsho	2983	5	occurring	occur	VBG
cord-006229-7yoilsho	2983	6	mixtures	mixture	NNS
cord-006229-7yoilsho	2983	7	with	with	IN
cord-006229-7yoilsho	2983	8	non	non	JJ
cord-006229-7yoilsho	2983	9	-	-	JJ
cord-006229-7yoilsho	2983	10	carcinogenic	carcinogenic	JJ
cord-006229-7yoilsho	2983	11	PAH	pah	NN
cord-006229-7yoilsho	2983	12	can	can	MD
cord-006229-7yoilsho	2983	13	modulate	modulate	VB
cord-006229-7yoilsho	2983	14	the	the	DT
cord-006229-7yoilsho	2983	15	effects	effect	NNS
cord-006229-7yoilsho	2983	16	of	of	IN
cord-006229-7yoilsho	2983	17	carcinogenic	carcinogenic	JJ
cord-006229-7yoilsho	2983	18	PAH	pah	NN
cord-006229-7yoilsho	2983	19	.	.	.
cord-006229-7yoilsho	2984	1	Such	such	JJ
cord-006229-7yoilsho	2984	2	effects	effect	NNS
cord-006229-7yoilsho	2984	3	warrant	warrant	VBP
cord-006229-7yoilsho	2984	4	to	to	TO
cord-006229-7yoilsho	2984	5	be	be	VB
cord-006229-7yoilsho	2984	6	investigated	investigate	VBN
cord-006229-7yoilsho	2984	7	in	in	IN
cord-006229-7yoilsho	2984	8	more	more	JJR
cord-006229-7yoilsho	2984	9	detail	detail	NN
cord-006229-7yoilsho	2984	10	to	to	TO
cord-006229-7yoilsho	2984	11	enhance	enhance	VB
cord-006229-7yoilsho	2984	12	our	-PRON-	PRP$
cord-006229-7yoilsho	2984	13	knowledge	knowledge	NN
cord-006229-7yoilsho	2984	14	of	of	IN
cord-006229-7yoilsho	2984	15	interaction	interaction	NN
cord-006229-7yoilsho	2984	16	of	of	IN
cord-006229-7yoilsho	2984	17	PAH	PAH	NNP
cord-006229-7yoilsho	2984	18	mixtures	mixture	NNS
cord-006229-7yoilsho	2984	19	at	at	IN
cord-006229-7yoilsho	2984	20	the	the	DT
cord-006229-7yoilsho	2984	21	molecular	molecular	JJ
cord-006229-7yoilsho	2984	22	level	level	NN
cord-006229-7yoilsho	2984	23	.	.	.
cord-006229-7yoilsho	2985	1	Cytochrome	cytochrome	NN
cord-006229-7yoilsho	2985	2	P450	p450	JJ
cord-006229-7yoilsho	2985	3	enzymes	enzyme	NNS
cord-006229-7yoilsho	2985	4	and	and	CC
cord-006229-7yoilsho	2985	5	transporters	transporter	NNS
cord-006229-7yoilsho	2985	6	are	be	VBP
cord-006229-7yoilsho	2985	7	important	important	JJ
cord-006229-7yoilsho	2985	8	for	for	IN
cord-006229-7yoilsho	2985	9	the	the	DT
cord-006229-7yoilsho	2985	10	turnover	turnover	NN
cord-006229-7yoilsho	2985	11	of	of	IN
cord-006229-7yoilsho	2985	12	pharmaceutical	pharmaceutical	JJ
cord-006229-7yoilsho	2985	13	compounds	compound	NNS
cord-006229-7yoilsho	2985	14	.	.	.
cord-006229-7yoilsho	2986	1	Their	-PRON-	PRP$
cord-006229-7yoilsho	2986	2	expression	expression	NN
cord-006229-7yoilsho	2986	3	levels	level	NNS
cord-006229-7yoilsho	2986	4	and	and	CC
cord-006229-7yoilsho	2986	5	activity	activity	NN
cord-006229-7yoilsho	2986	6	influence	influence	NN
cord-006229-7yoilsho	2986	7	bioavailability	bioavailability	NN
cord-006229-7yoilsho	2986	8	and	and	CC
cord-006229-7yoilsho	2986	9	convey	convey	VB
cord-006229-7yoilsho	2986	10	drug	drug	NN
cord-006229-7yoilsho	2986	11	-	-	HYPH
cord-006229-7yoilsho	2986	12	drug	drug	NN
cord-006229-7yoilsho	2986	13	interactions	interaction	NNS
cord-006229-7yoilsho	2986	14	.	.	.
cord-006229-7yoilsho	2987	1	Moreover	moreover	RB
cord-006229-7yoilsho	2987	2	,	,	,
cord-006229-7yoilsho	2987	3	transporters	transporter	NNS
cord-006229-7yoilsho	2987	4	mediate	mediate	VBP
cord-006229-7yoilsho	2987	5	barrier	barrier	NN
cord-006229-7yoilsho	2987	6	maintenance	maintenance	NN
cord-006229-7yoilsho	2987	7	of	of	IN
cord-006229-7yoilsho	2987	8	several	several	JJ
cord-006229-7yoilsho	2987	9	organs	organ	NNS
cord-006229-7yoilsho	2987	10	such	such	JJ
cord-006229-7yoilsho	2987	11	as	as	IN
cord-006229-7yoilsho	2987	12	blood	blood	NN
cord-006229-7yoilsho	2987	13	-	-	HYPH
cord-006229-7yoilsho	2987	14	brain	brain	NN
cord-006229-7yoilsho	2987	15	-	-	HYPH
cord-006229-7yoilsho	2987	16	barrier	barrier	NN
cord-006229-7yoilsho	2987	17	and	and	CC
cord-006229-7yoilsho	2987	18	placenta	placenta	NN
cord-006229-7yoilsho	2987	19	-	-	HYPH
cord-006229-7yoilsho	2987	20	barrier	barrier	NN
cord-006229-7yoilsho	2987	21	.	.	.
cord-006229-7yoilsho	2988	1	Overexpression	overexpression	NN
cord-006229-7yoilsho	2988	2	of	of	IN
cord-006229-7yoilsho	2988	3	export	export	NN
cord-006229-7yoilsho	2988	4	transporters	transporter	NNS
cord-006229-7yoilsho	2988	5	in	in	IN
cord-006229-7yoilsho	2988	6	tumors	tumor	NNS
cord-006229-7yoilsho	2988	7	can	can	MD
cord-006229-7yoilsho	2988	8	lead	lead	VB
cord-006229-7yoilsho	2988	9	to	to	IN
cord-006229-7yoilsho	2988	10	multiple	multiple	JJ
cord-006229-7yoilsho	2988	11	drug	drug	NN
cord-006229-7yoilsho	2988	12	resistance	resistance	NN
cord-006229-7yoilsho	2988	13	.	.	.
cord-006229-7yoilsho	2989	1	However	however	RB
cord-006229-7yoilsho	2989	2	,	,	,
cord-006229-7yoilsho	2989	3	membrane	membrane	NN
cord-006229-7yoilsho	2989	4	associated	associate	VBN
cord-006229-7yoilsho	2989	5	proteins	protein	NNS
cord-006229-7yoilsho	2989	6	are	be	VBP
cord-006229-7yoilsho	2989	7	difficult	difficult	JJ
cord-006229-7yoilsho	2989	8	to	to	TO
cord-006229-7yoilsho	2989	9	quantify	quantify	VB
cord-006229-7yoilsho	2989	10	by	by	IN
cord-006229-7yoilsho	2989	11	conventional	conventional	JJ
cord-006229-7yoilsho	2989	12	bioanalytical	bioanalytical	JJ
cord-006229-7yoilsho	2989	13	methods	method	NNS
cord-006229-7yoilsho	2989	14	such	such	JJ
cord-006229-7yoilsho	2989	15	as	as	IN
cord-006229-7yoilsho	2989	16	sandwich	sandwich	NN
cord-006229-7yoilsho	2989	17	immunoassays	immunoassay	NNS
cord-006229-7yoilsho	2989	18	because	because	IN
cord-006229-7yoilsho	2989	19	of	of	IN
cord-006229-7yoilsho	2989	20	their	-PRON-	PRP$
cord-006229-7yoilsho	2989	21	hydrophobicity	hydrophobicity	NN
cord-006229-7yoilsho	2989	22	.	.	.
cord-006229-7yoilsho	2990	1	Antibody	antibody	NN
cord-006229-7yoilsho	2990	2	-based	-base	VBN
cord-006229-7yoilsho	2991	1	analysis	analysis	NN
cord-006229-7yoilsho	2991	2	of	of	IN
cord-006229-7yoilsho	2991	3	cytochrome	cytochrome	NN
cord-006229-7yoilsho	2991	4	P450	p450	JJ
cord-006229-7yoilsho	2991	5	enzymes	enzyme	NNS
cord-006229-7yoilsho	2991	6	and	and	CC
cord-006229-7yoilsho	2991	7	transporters	transporter	NNS
cord-006229-7yoilsho	2991	8	is	be	VBZ
cord-006229-7yoilsho	2991	9	challenging	challenge	VBG
cord-006229-7yoilsho	2991	10	due	due	IN
cord-006229-7yoilsho	2991	11	to	to	IN
cord-006229-7yoilsho	2991	12	their	-PRON-	PRP$
cord-006229-7yoilsho	2991	13	sequence	sequence	NN
cord-006229-7yoilsho	2991	14	homology	homology	NN
cord-006229-7yoilsho	2991	15	.	.	.
cord-006229-7yoilsho	2992	1	Therefore	therefore	RB
cord-006229-7yoilsho	2992	2	,	,	,
cord-006229-7yoilsho	2992	3	we	-PRON-	PRP
cord-006229-7yoilsho	2992	4	developed	develop	VBD
cord-006229-7yoilsho	2992	5	a	a	DT
cord-006229-7yoilsho	2992	6	test	test	NN
cord-006229-7yoilsho	2992	7	system	system	NN
cord-006229-7yoilsho	2992	8	for	for	IN
cord-006229-7yoilsho	2992	9	protein	protein	NN
cord-006229-7yoilsho	2992	10	quantification	quantification	NN
cord-006229-7yoilsho	2992	11	which	which	WDT
cord-006229-7yoilsho	2992	12	combines	combine	VBZ
cord-006229-7yoilsho	2992	13	the	the	DT
cord-006229-7yoilsho	2992	14	sensitivity	sensitivity	NN
cord-006229-7yoilsho	2992	15	of	of	IN
cord-006229-7yoilsho	2992	16	immunoprecipitation	immunoprecipitation	NN
cord-006229-7yoilsho	2992	17	and	and	CC
cord-006229-7yoilsho	2992	18	the	the	DT
cord-006229-7yoilsho	2992	19	specificity	specificity	NN
cord-006229-7yoilsho	2992	20	of	of	IN
cord-006229-7yoilsho	2992	21	mass	mass	NN
cord-006229-7yoilsho	2992	22	spectrometry	spectrometry	NN
cord-006229-7yoilsho	2992	23	:	:	:
cord-006229-7yoilsho	2993	1	This	this	DT
cord-006229-7yoilsho	2993	2	method	method	NN
cord-006229-7yoilsho	2993	3	is	be	VBZ
cord-006229-7yoilsho	2993	4	especially	especially	RB
cord-006229-7yoilsho	2993	5	convenient	convenient	JJ
cord-006229-7yoilsho	2993	6	for	for	IN
cord-006229-7yoilsho	2993	7	hydrophobic	hydrophobic	JJ
cord-006229-7yoilsho	2993	8	proteins	protein	NNS
cord-006229-7yoilsho	2993	9	because	because	IN
cord-006229-7yoilsho	2993	10	denatured	denatured	JJ
cord-006229-7yoilsho	2993	11	samples	sample	NNS
cord-006229-7yoilsho	2993	12	are	be	VBP
cord-006229-7yoilsho	2993	13	analyzed	analyze	VBN
cord-006229-7yoilsho	2993	14	on	on	IN
cord-006229-7yoilsho	2993	15	peptide	peptide	JJ
cord-006229-7yoilsho	2993	16	level	level	NN
cord-006229-7yoilsho	2993	17	.	.	.
cord-006229-7yoilsho	2994	1	One	one	CD
cord-006229-7yoilsho	2994	2	peptide	peptide	NN
cord-006229-7yoilsho	2994	3	from	from	IN
cord-006229-7yoilsho	2994	4	each	each	DT
cord-006229-7yoilsho	2994	5	protein	protein	NN
cord-006229-7yoilsho	2994	6	,	,	,
cord-006229-7yoilsho	2994	7	which	which	WDT
cord-006229-7yoilsho	2994	8	can	can	MD
cord-006229-7yoilsho	2994	9	be	be	VB
cord-006229-7yoilsho	2994	10	assigned	assign	VBN
cord-006229-7yoilsho	2994	11	unambiguously	unambiguously	RB
cord-006229-7yoilsho	2994	12	,	,	,
cord-006229-7yoilsho	2994	13	is	be	VBZ
cord-006229-7yoilsho	2994	14	identified	identify	VBN
cord-006229-7yoilsho	2994	15	via	via	IN
cord-006229-7yoilsho	2994	16	tandem	tandem	JJ
cord-006229-7yoilsho	2994	17	MS	MS	NNP
cord-006229-7yoilsho	2994	18	and	and	CC
cord-006229-7yoilsho	2994	19	quantified	quantify	VBN
cord-006229-7yoilsho	2994	20	by	by	IN
cord-006229-7yoilsho	2994	21	means	mean	NNS
cord-006229-7yoilsho	2994	22	of	of	IN
cord-006229-7yoilsho	2994	23	an	an	DT
cord-006229-7yoilsho	2994	24	isotope	isotope	NN
cord-006229-7yoilsho	2994	25	labeled	label	VBN
cord-006229-7yoilsho	2994	26	reference	reference	NN
cord-006229-7yoilsho	2994	27	.	.	.
cord-006229-7yoilsho	2995	1	Prior	prior	RB
cord-006229-7yoilsho	2995	2	to	to	IN
cord-006229-7yoilsho	2995	3	MS	MS	NNP
cord-006229-7yoilsho	2995	4	-	-	HYPH
cord-006229-7yoilsho	2995	5	read	read	VB
cord-006229-7yoilsho	2995	6	-	-	HYPH
cord-006229-7yoilsho	2995	7	out	out	NN
cord-006229-7yoilsho	2995	8	,	,	,
cord-006229-7yoilsho	2995	9	the	the	DT
cord-006229-7yoilsho	2995	10	peptides	peptide	NNS
cord-006229-7yoilsho	2995	11	are	be	VBP
cord-006229-7yoilsho	2995	12	enriched	enrich	VBN
cord-006229-7yoilsho	2995	13	by	by	IN
cord-006229-7yoilsho	2995	14	antibodies	antibody	NNS
cord-006229-7yoilsho	2995	15	which	which	WDT
cord-006229-7yoilsho	2995	16	recognize	recognize	VBP
cord-006229-7yoilsho	2995	17	a	a	DT
cord-006229-7yoilsho	2995	18	very	very	RB
cord-006229-7yoilsho	2995	19	short	short	JJ
cord-006229-7yoilsho	2995	20	c	c	NN
cord-006229-7yoilsho	2995	21	-	-	HYPH
cord-006229-7yoilsho	2995	22	terminal	terminal	NN
cord-006229-7yoilsho	2995	23	epitope	epitope	NN
cord-006229-7yoilsho	2995	24	.	.	.
cord-006229-7yoilsho	2996	1	These	these	DT
cord-006229-7yoilsho	2996	2	epitopes	epitope	NNS
cord-006229-7yoilsho	2996	3	are	be	VBP
cord-006229-7yoilsho	2996	4	selected	select	VBN
cord-006229-7yoilsho	2996	5	in	in	IN
cord-006229-7yoilsho	2996	6	such	such	JJ
cord-006229-7yoilsho	2996	7	way	way	NN
cord-006229-7yoilsho	2996	8	that	that	IN
cord-006229-7yoilsho	2996	9	they	-PRON-	PRP
cord-006229-7yoilsho	2996	10	are	be	VBP
cord-006229-7yoilsho	2996	11	common	common	JJ
cord-006229-7yoilsho	2996	12	in	in	IN
cord-006229-7yoilsho	2996	13	peptides	peptide	NNS
cord-006229-7yoilsho	2996	14	derived	derive	VBN
cord-006229-7yoilsho	2996	15	from	from	IN
cord-006229-7yoilsho	2996	16	target	target	NN
cord-006229-7yoilsho	2996	17	proteins	protein	NNS
cord-006229-7yoilsho	2996	18	and	and	CC
cord-006229-7yoilsho	2996	19	therefore	therefore	RB
cord-006229-7yoilsho	2996	20	allow	allow	VB
cord-006229-7yoilsho	2996	21	the	the	DT
cord-006229-7yoilsho	2996	22	analysis	analysis	NN
cord-006229-7yoilsho	2996	23	of	of	IN
cord-006229-7yoilsho	2996	24	protein	protein	NN
cord-006229-7yoilsho	2996	25	groups	group	NNS
cord-006229-7yoilsho	2996	26	with	with	IN
cord-006229-7yoilsho	2996	27	few	few	JJ
cord-006229-7yoilsho	2996	28	antibodies	antibody	NNS
cord-006229-7yoilsho	2996	29	.	.	.
cord-006229-7yoilsho	2997	1	The	the	DT
cord-006229-7yoilsho	2997	2	major	major	JJ
cord-006229-7yoilsho	2997	3	advantage	advantage	NN
cord-006229-7yoilsho	2997	4	of	of	IN
cord-006229-7yoilsho	2997	5	this	this	DT
cord-006229-7yoilsho	2997	6	method	method	NN
cord-006229-7yoilsho	2997	7	is	be	VBZ
cord-006229-7yoilsho	2997	8	that	that	DT
cord-006229-7yoilsho	2997	9	whole	whole	JJ
cord-006229-7yoilsho	2997	10	cell	cell	NN
cord-006229-7yoilsho	2997	11	or	or	CC
cord-006229-7yoilsho	2997	12	tissue	tissue	NN
cord-006229-7yoilsho	2997	13	lysates	lysate	NNS
cord-006229-7yoilsho	2997	14	-without	-without	:
cord-006229-7yoilsho	2997	15	preparation	preparation	NN
cord-006229-7yoilsho	2997	16	of	of	IN
cord-006229-7yoilsho	2997	17	microsomal	microsomal	NNP
cord-006229-7yoilsho	2997	18	fractions	fraction	NNS
cord-006229-7yoilsho	2997	19	-can	-can	-LRB-
cord-006229-7yoilsho	2997	20	be	be	VB
cord-006229-7yoilsho	2997	21	used	use	VBN
cord-006229-7yoilsho	2997	22	for	for	IN
cord-006229-7yoilsho	2997	23	quantification	quantification	NN
cord-006229-7yoilsho	2997	24	by	by	IN
cord-006229-7yoilsho	2997	25	LC	LC	NNP
cord-006229-7yoilsho	2997	26	-	-	HYPH
cord-006229-7yoilsho	2997	27	MS	MS	NNP
cord-006229-7yoilsho	2997	28	.	.	.
cord-006229-7yoilsho	2998	1	Also	also	RB
cord-006229-7yoilsho	2998	2	,	,	,
cord-006229-7yoilsho	2998	3	samples	sample	NNS
cord-006229-7yoilsho	2998	4	from	from	IN
cord-006229-7yoilsho	2998	5	different	different	JJ
cord-006229-7yoilsho	2998	6	model	model	NN
cord-006229-7yoilsho	2998	7	organisms	organism	NNS
cord-006229-7yoilsho	2998	8	can	can	MD
cord-006229-7yoilsho	2998	9	be	be	VB
cord-006229-7yoilsho	2998	10	analyzed	analyze	VBN
cord-006229-7yoilsho	2998	11	with	with	IN
cord-006229-7yoilsho	2998	12	the	the	DT
cord-006229-7yoilsho	2998	13	same	same	JJ
cord-006229-7yoilsho	2998	14	assay	assay	NN
cord-006229-7yoilsho	2998	15	which	which	WDT
cord-006229-7yoilsho	2998	16	enhances	enhance	VBZ
cord-006229-7yoilsho	2998	17	the	the	DT
cord-006229-7yoilsho	2998	18	comparability	comparability	NN
cord-006229-7yoilsho	2998	19	of	of	IN
cord-006229-7yoilsho	2998	20	experiments	experiment	NNS
cord-006229-7yoilsho	2998	21	.	.	.
cord-006229-7yoilsho	2999	1	Physiologically	physiologically	RB
cord-006229-7yoilsho	2999	2	Based	Based	NNP
cord-006229-7yoilsho	2999	3	Toxicokinetic	Toxicokinetic	NNP
cord-006229-7yoilsho	2999	4	Modeling	Modeling	NNP
cord-006229-7yoilsho	2999	5	(	(	-LRB-
cord-006229-7yoilsho	2999	6	PBTK	PBTK	NNP
cord-006229-7yoilsho	2999	7	)	)	-RRB-
cord-006229-7yoilsho	2999	8	is	be	VBZ
cord-006229-7yoilsho	2999	9	an	an	DT
cord-006229-7yoilsho	2999	10	in	in	IN
cord-006229-7yoilsho	2999	11	silico	silico	NN
cord-006229-7yoilsho	2999	12	tool	tool	NN
cord-006229-7yoilsho	2999	13	to	to	TO
cord-006229-7yoilsho	2999	14	predict	predict	VB
cord-006229-7yoilsho	2999	15	compound	compound	NN
cord-006229-7yoilsho	2999	16	kinetics	kinetic	NNS
cord-006229-7yoilsho	2999	17	based	base	VBN
cord-006229-7yoilsho	2999	18	on	on	IN
cord-006229-7yoilsho	2999	19	test	test	NN
cord-006229-7yoilsho	2999	20	substance	substance	NN
cord-006229-7yoilsho	2999	21	related	relate	VBN
cord-006229-7yoilsho	2999	22	properties	property	NNS
cord-006229-7yoilsho	2999	23	and	and	CC
cord-006229-7yoilsho	2999	24	physiological	physiological	JJ
cord-006229-7yoilsho	2999	25	parameters	parameter	NNS
cord-006229-7yoilsho	2999	26	of	of	IN
cord-006229-7yoilsho	2999	27	the	the	DT
cord-006229-7yoilsho	2999	28	organism	organism	NN
cord-006229-7yoilsho	2999	29	.	.	.
cord-006229-7yoilsho	3000	1	PBTK	PBTK	NNP
cord-006229-7yoilsho	3000	2	is	be	VBZ
cord-006229-7yoilsho	3000	3	a	a	DT
cord-006229-7yoilsho	3000	4	key	key	JJ
cord-006229-7yoilsho	3000	5	element	element	NN
cord-006229-7yoilsho	3000	6	for	for	IN
cord-006229-7yoilsho	3000	7	inverse	inverse	JJ
cord-006229-7yoilsho	3000	8	dosimetry	dosimetry	NN
cord-006229-7yoilsho	3000	9	to	to	TO
cord-006229-7yoilsho	3000	10	relate	relate	VB
cord-006229-7yoilsho	3000	11	effect	effect	NN
cord-006229-7yoilsho	3000	12	concentrations	concentration	NNS
cord-006229-7yoilsho	3000	13	in	in	IN
cord-006229-7yoilsho	3000	14	vitro	vitro	FW
cord-006229-7yoilsho	3000	15	to	to	IN
cord-006229-7yoilsho	3000	16	external	external	JJ
cord-006229-7yoilsho	3000	17	,	,	,
cord-006229-7yoilsho	3000	18	e.g.	e.g.	IN
cord-006229-7yoilsho	3000	19	oral	oral	JJ
cord-006229-7yoilsho	3000	20	doses	dose	NNS
cord-006229-7yoilsho	3000	21	.	.	.
cord-006229-7yoilsho	3001	1	In	in	IN
cord-006229-7yoilsho	3001	2	our	-PRON-	PRP$
cord-006229-7yoilsho	3001	3	investigations	investigation	NNS
cord-006229-7yoilsho	3001	4	,	,	,
cord-006229-7yoilsho	3001	5	we	-PRON-	PRP
cord-006229-7yoilsho	3001	6	use	use	VBP
cord-006229-7yoilsho	3001	7	8	8	CD
cord-006229-7yoilsho	3001	8	compartment	compartment	NN
cord-006229-7yoilsho	3001	9	models	model	NNS
cord-006229-7yoilsho	3001	10	for	for	IN
cord-006229-7yoilsho	3001	11	the	the	DT
cord-006229-7yoilsho	3001	12	rat	rat	NN
cord-006229-7yoilsho	3001	13	including	include	VBG
cord-006229-7yoilsho	3001	14	adrenals	adrenal	NNS
cord-006229-7yoilsho	3001	15	and	and	CC
cord-006229-7yoilsho	3001	16	testes	testis	NNS
cord-006229-7yoilsho	3001	17	or	or	CC
cord-006229-7yoilsho	3001	18	ovaries	ovary	NNS
cord-006229-7yoilsho	3001	19	.	.	.
cord-006229-7yoilsho	3002	1	Test	test	NN
cord-006229-7yoilsho	3002	2	substance	substance	NN
cord-006229-7yoilsho	3002	3	specific	specific	JJ
cord-006229-7yoilsho	3002	4	properties	property	NNS
cord-006229-7yoilsho	3002	5	taken	take	VBN
cord-006229-7yoilsho	3002	6	for	for	IN
cord-006229-7yoilsho	3002	7	PBTK	pbtk	JJ
cord-006229-7yoilsho	3002	8	modeling	modeling	NN
cord-006229-7yoilsho	3002	9	are	be	VBP
cord-006229-7yoilsho	3002	10	molecular	molecular	JJ
cord-006229-7yoilsho	3002	11	weight	weight	NN
cord-006229-7yoilsho	3002	12	and	and	CC
cord-006229-7yoilsho	3002	13	logP	logP	NNP
cord-006229-7yoilsho	3002	14	O	O	NNP
cord-006229-7yoilsho	3002	15	/	/	SYM
cord-006229-7yoilsho	3002	16	W	W	NNP
cord-006229-7yoilsho	3002	17	as	as	RB
cord-006229-7yoilsho	3002	18	well	well	RB
cord-006229-7yoilsho	3002	19	as	as	IN
cord-006229-7yoilsho	3002	20	IVIS	IVIS	NNP
cord-006229-7yoilsho	3002	21	based	base	VBD
cord-006229-7yoilsho	3002	22	tissue	tissue	NN
cord-006229-7yoilsho	3002	23	specific	specific	JJ
cord-006229-7yoilsho	3002	24	partition	partition	NN
cord-006229-7yoilsho	3002	25	coefficients	coefficient	NNS
cord-006229-7yoilsho	3002	26	,	,	,
cord-006229-7yoilsho	3002	27	hepatic	hepatic	JJ
cord-006229-7yoilsho	3002	28	clearance	clearance	NN
cord-006229-7yoilsho	3002	29	,	,	,
cord-006229-7yoilsho	3002	30	intestinal	intestinal	JJ
cord-006229-7yoilsho	3002	31	permeability	permeability	NN
cord-006229-7yoilsho	3002	32	and	and	CC
cord-006229-7yoilsho	3002	33	plasma	plasma	NN
cord-006229-7yoilsho	3002	34	protein	protein	NN
cord-006229-7yoilsho	3002	35	binding	binding	NN
cord-006229-7yoilsho	3002	36	.	.	.
cord-006229-7yoilsho	3003	1	Berkeley	Berkeley	NNP
cord-006229-7yoilsho	3003	2	Madonna	Madonna	NNP
cord-006229-7yoilsho	3003	3	Software	Software	NNP
cord-006229-7yoilsho	3003	4	was	be	VBD
cord-006229-7yoilsho	3003	5	applied	apply	VBN
cord-006229-7yoilsho	3003	6	to	to	TO
cord-006229-7yoilsho	3003	7	solve	solve	VB
cord-006229-7yoilsho	3003	8	consequent	consequent	JJ
cord-006229-7yoilsho	3003	9	differential	differential	JJ
cord-006229-7yoilsho	3003	10	equations	equation	NNS
cord-006229-7yoilsho	3003	11	.	.	.
cord-006229-7yoilsho	3004	1	Here	here	RB
cord-006229-7yoilsho	3004	2	we	-PRON-	PRP
cord-006229-7yoilsho	3004	3	present	present	VBP
cord-006229-7yoilsho	3004	4	the	the	DT
cord-006229-7yoilsho	3004	5	above	above	RB
cord-006229-7yoilsho	3004	6	described	describe	VBN
cord-006229-7yoilsho	3004	7	model	model	NN
cord-006229-7yoilsho	3004	8	for	for	IN
cord-006229-7yoilsho	3004	9	the	the	DT
cord-006229-7yoilsho	3004	10	3	3	CD
cord-006229-7yoilsho	3004	11	test	test	NN
cord-006229-7yoilsho	3004	12	substances	substance	NNS
cord-006229-7yoilsho	3004	13	bisphenol	bisphenol	NNP
cord-006229-7yoilsho	3004	14	A	A	NNP
cord-006229-7yoilsho	3004	15	(	(	-LRB-
cord-006229-7yoilsho	3004	16	BPA	BPA	NNP
cord-006229-7yoilsho	3004	17	)	)	-RRB-
cord-006229-7yoilsho	3004	18	,	,	,
cord-006229-7yoilsho	3004	19	fenarimol	fenarimol	NNP
cord-006229-7yoilsho	3004	20	(	(	-LRB-
cord-006229-7yoilsho	3004	21	FEN	FEN	NNP
cord-006229-7yoilsho	3004	22	)	)	-RRB-
cord-006229-7yoilsho	3004	23	and	and	CC
cord-006229-7yoilsho	3004	24	ketoconazole	ketoconazole	NNP
cord-006229-7yoilsho	3004	25	(	(	-LRB-
cord-006229-7yoilsho	3004	26	KETO	KETO	NNP
cord-006229-7yoilsho	3004	27	)	)	-RRB-
cord-006229-7yoilsho	3004	28	.	.	.
cord-006229-7yoilsho	3005	1	Using	use	VBG
cord-006229-7yoilsho	3005	2	the	the	DT
cord-006229-7yoilsho	3005	3	lowest	low	JJS
cord-006229-7yoilsho	3005	4	effect	effect	NN
cord-006229-7yoilsho	3005	5	concentrations	concentration	NNS
cord-006229-7yoilsho	3005	6	(	(	-LRB-
cord-006229-7yoilsho	3005	7	LOECs	loec	NNS
cord-006229-7yoilsho	3005	8	)	)	-RRB-
cord-006229-7yoilsho	3005	9	of	of	IN
cord-006229-7yoilsho	3005	10	BPA	BPA	NNP
cord-006229-7yoilsho	3005	11	,	,	,
cord-006229-7yoilsho	3005	12	FEN	FEN	NNP
cord-006229-7yoilsho	3005	13	and	and	CC
cord-006229-7yoilsho	3005	14	KETO	KETO	NNP
cord-006229-7yoilsho	3005	15	from	from	IN
cord-006229-7yoilsho	3005	16	1	1	CD
cord-006229-7yoilsho	3005	17	)	)	-RRB-
cord-006229-7yoilsho	3005	18	an	an	DT
cord-006229-7yoilsho	3005	19	in	in	FW
cord-006229-7yoilsho	3005	20	vitro	vitro	FW
cord-006229-7yoilsho	3005	21	yeast	yeast	NN
cord-006229-7yoilsho	3005	22	based	base	VBN
cord-006229-7yoilsho	3005	23	assays	assay	NNS
cord-006229-7yoilsho	3005	24	with	with	IN
cord-006229-7yoilsho	3005	25	human	human	JJ
cord-006229-7yoilsho	3005	26	estrogen	estrogen	NN
cord-006229-7yoilsho	3005	27	and	and	CC
cord-006229-7yoilsho	3005	28	androgen	androgen	NN
cord-006229-7yoilsho	3005	29	receptor	receptor	NN
cord-006229-7yoilsho	3005	30	combined	combine	VBN
cord-006229-7yoilsho	3005	31	with	with	IN
cord-006229-7yoilsho	3005	32	a	a	DT
cord-006229-7yoilsho	3005	33	reporter	reporter	NN
cord-006229-7yoilsho	3005	34	gene	gene	NN
cord-006229-7yoilsho	3005	35	and	and	CC
cord-006229-7yoilsho	3005	36	2	2	CD
cord-006229-7yoilsho	3005	37	)	)	-RRB-
cord-006229-7yoilsho	3006	1	the	the	DT
cord-006229-7yoilsho	3006	2	interaction	interaction	NN
cord-006229-7yoilsho	3006	3	of	of	IN
cord-006229-7yoilsho	3006	4	steroidogenesis	steroidogenesis	NN
cord-006229-7yoilsho	3006	5	model	model	NN
cord-006229-7yoilsho	3006	6	calculations	calculation	NNS
cord-006229-7yoilsho	3006	7	were	be	VBD
cord-006229-7yoilsho	3006	8	made	make	VBN
cord-006229-7yoilsho	3006	9	to	to	TO
cord-006229-7yoilsho	3006	10	relate	relate	VB
cord-006229-7yoilsho	3006	11	in	in	IN
cord-006229-7yoilsho	3006	12	vitro	vitro	FW
cord-006229-7yoilsho	3006	13	concentrations	concentration	NNS
cord-006229-7yoilsho	3006	14	to	to	IN
cord-006229-7yoilsho	3006	15	oral	oral	JJ
cord-006229-7yoilsho	3006	16	doses	dose	NNS
cord-006229-7yoilsho	3006	17	in	in	IN
cord-006229-7yoilsho	3006	18	the	the	DT
cord-006229-7yoilsho	3006	19	rat	rat	NN
cord-006229-7yoilsho	3006	20	.	.	.
cord-006229-7yoilsho	3007	1	Model	model	NN
cord-006229-7yoilsho	3007	2	calculations	calculation	NNS
cord-006229-7yoilsho	3007	3	,	,	,
cord-006229-7yoilsho	3007	4	based	base	VBN
cord-006229-7yoilsho	3007	5	on	on	IN
cord-006229-7yoilsho	3007	6	in	in	IN
cord-006229-7yoilsho	3007	7	vitro	vitro	FW
cord-006229-7yoilsho	3007	8	LOECs	loec	NNS
cord-006229-7yoilsho	3007	9	of	of	IN
cord-006229-7yoilsho	3007	10	10	10	CD
cord-006229-7yoilsho	3007	11	µM	µm	NN
cord-006229-7yoilsho	3007	12	(	(	-LRB-
cord-006229-7yoilsho	3007	13	BPA	BPA	NNP
cord-006229-7yoilsho	3007	14	)	)	-RRB-
cord-006229-7yoilsho	3007	15	,	,	,
cord-006229-7yoilsho	3007	16	3	3	CD
cord-006229-7yoilsho	3007	17	µM	µm	NN
cord-006229-7yoilsho	3007	18	(	(	-LRB-
cord-006229-7yoilsho	3007	19	FEN	FEN	NNP
cord-006229-7yoilsho	3007	20	)	)	-RRB-
cord-006229-7yoilsho	3007	21	and	and	CC
cord-006229-7yoilsho	3007	22	0.01	0.01	CD
cord-006229-7yoilsho	3007	23	µM	µM	NFP
cord-006229-7yoilsho	3007	24	(	(	-LRB-
cord-006229-7yoilsho	3007	25	KETO	KETO	NNP
cord-006229-7yoilsho	3007	26	)	)	-RRB-
cord-006229-7yoilsho	3007	27	,	,	,
cord-006229-7yoilsho	3007	28	for	for	IN
cord-006229-7yoilsho	3007	29	concentrations	concentration	NNS
cord-006229-7yoilsho	3007	30	in	in	IN
cord-006229-7yoilsho	3007	31	target	target	NN
cord-006229-7yoilsho	3007	32	organs	organ	NNS
cord-006229-7yoilsho	3007	33	resulted	result	VBD
cord-006229-7yoilsho	3007	34	in	in	IN
cord-006229-7yoilsho	3007	35	estimated	estimate	VBN
cord-006229-7yoilsho	3007	36	oral	oral	JJ
cord-006229-7yoilsho	3007	37	LOELs	loel	NNS
cord-006229-7yoilsho	3007	38	of	of	IN
cord-006229-7yoilsho	3007	39	16	16	CD
cord-006229-7yoilsho	3007	40	,	,	,
cord-006229-7yoilsho	3007	41	4	4	CD
cord-006229-7yoilsho	3007	42	and	and	CC
cord-006229-7yoilsho	3007	43	0.04	0.04	CD
cord-006229-7yoilsho	3007	44	mg	mg	NNS
cord-006229-7yoilsho	3007	45	/	/	SYM
cord-006229-7yoilsho	3007	46	kg	kg	NN
cord-006229-7yoilsho	3007	47	.	.	.
cord-006229-7yoilsho	3008	1	When	when	WRB
cord-006229-7yoilsho	3008	2	calculations	calculation	NNS
cord-006229-7yoilsho	3008	3	were	be	VBD
cord-006229-7yoilsho	3008	4	made	make	VBN
cord-006229-7yoilsho	3008	5	for	for	IN
cord-006229-7yoilsho	3008	6	plasma	plasma	NN
cord-006229-7yoilsho	3008	7	levels	level	NNS
cord-006229-7yoilsho	3008	8	oral	oral	JJ
cord-006229-7yoilsho	3008	9	LOELs	loel	NNS
cord-006229-7yoilsho	3008	10	were	be	VBD
cord-006229-7yoilsho	3008	11	estimated	estimate	VBN
cord-006229-7yoilsho	3008	12	to	to	TO
cord-006229-7yoilsho	3008	13	be	be	VB
cord-006229-7yoilsho	3008	14	608	608	CD
cord-006229-7yoilsho	3008	15	,	,	,
cord-006229-7yoilsho	3008	16	77	77	CD
cord-006229-7yoilsho	3008	17	and	and	CC
cord-006229-7yoilsho	3008	18	16	16	CD
cord-006229-7yoilsho	3008	19	mg	mg	NNP
cord-006229-7yoilsho	3008	20	/	/	SYM
cord-006229-7yoilsho	3008	21	kg	kg	NNP
cord-006229-7yoilsho	3008	22	for	for	IN
cord-006229-7yoilsho	3008	23	BPA	BPA	NNP
cord-006229-7yoilsho	3008	24	,	,	,
cord-006229-7yoilsho	3008	25	FEN	FEN	NNP
cord-006229-7yoilsho	3008	26	and	and	CC
cord-006229-7yoilsho	3008	27	KETO	KETO	NNP
cord-006229-7yoilsho	3008	28	,	,	,
cord-006229-7yoilsho	3008	29	respectively	respectively	RB
cord-006229-7yoilsho	3008	30	When	when	WRB
cord-006229-7yoilsho	3008	31	compared	compare	VBN
cord-006229-7yoilsho	3008	32	to	to	IN
cord-006229-7yoilsho	3008	33	existing	exist	VBG
cord-006229-7yoilsho	3008	34	in	in	IN
cord-006229-7yoilsho	3008	35	vivo	vivo	NN
cord-006229-7yoilsho	3008	36	data	datum	NNS
cord-006229-7yoilsho	3008	37	with	with	IN
cord-006229-7yoilsho	3008	38	endocrine	endocrine	JJ
cord-006229-7yoilsho	3008	39	related	relate	VBN
cord-006229-7yoilsho	3008	40	LOELs	loel	NNS
cord-006229-7yoilsho	3008	41	of	of	IN
cord-006229-7yoilsho	3008	42	375	375	CD
cord-006229-7yoilsho	3008	43	mg	mg	NNP
cord-006229-7yoilsho	3008	44	/	/	SYM
cord-006229-7yoilsho	3008	45	kg	kg	NNP
cord-006229-7yoilsho	3008	46	bw	bw	NNP
cord-006229-7yoilsho	3008	47	day	day	NN
cord-006229-7yoilsho	3008	48	for	for	IN
cord-006229-7yoilsho	3008	49	BPA	BPA	NNP
cord-006229-7yoilsho	3008	50	(	(	-LRB-
cord-006229-7yoilsho	3008	51	1	1	CD
cord-006229-7yoilsho	3008	52	)	)	-RRB-
cord-006229-7yoilsho	3008	53	,	,	,
cord-006229-7yoilsho	3008	54	50	50	CD
cord-006229-7yoilsho	3008	55	mg	mg	NNP
cord-006229-7yoilsho	3008	56	/	/	SYM
cord-006229-7yoilsho	3008	57	kg	kg	NNP
cord-006229-7yoilsho	3008	58	day	day	NN
cord-006229-7yoilsho	3008	59	for	for	IN
cord-006229-7yoilsho	3008	60	FEN	FEN	NNP
cord-006229-7yoilsho	3008	61	(	(	-LRB-
cord-006229-7yoilsho	3008	62	2	2	CD
cord-006229-7yoilsho	3008	63	)	)	-RRB-
cord-006229-7yoilsho	3008	64	and	and	CC
cord-006229-7yoilsho	3008	65	6	6	CD
cord-006229-7yoilsho	3008	66	mg	mg	NNP
cord-006229-7yoilsho	3008	67	/	/	SYM
cord-006229-7yoilsho	3008	68	kg	kg	NNP
cord-006229-7yoilsho	3008	69	day	day	NN
cord-006229-7yoilsho	3008	70	for	for	IN
cord-006229-7yoilsho	3008	71	KETO	KETO	NNP
cord-006229-7yoilsho	3008	72	(	(	-LRB-
cord-006229-7yoilsho	3008	73	3	3	CD
cord-006229-7yoilsho	3008	74	)	)	-RRB-
cord-006229-7yoilsho	3008	75	,	,	,
cord-006229-7yoilsho	3008	76	it	-PRON-	PRP
cord-006229-7yoilsho	3008	77	can	can	MD
cord-006229-7yoilsho	3008	78	be	be	VB
cord-006229-7yoilsho	3008	79	concluded	conclude	VBN
cord-006229-7yoilsho	3008	80	that	that	IN
cord-006229-7yoilsho	3008	81	for	for	IN
cord-006229-7yoilsho	3008	82	the	the	DT
cord-006229-7yoilsho	3008	83	exemplary	exemplary	JJ
cord-006229-7yoilsho	3008	84	test	test	NN
cord-006229-7yoilsho	3008	85	substances	substance	NNS
cord-006229-7yoilsho	3008	86	addressed	address	VBN
cord-006229-7yoilsho	3008	87	,	,	,
cord-006229-7yoilsho	3008	88	IVIS	IVIS	NNP
cord-006229-7yoilsho	3008	89	related	relate	VBD
cord-006229-7yoilsho	3008	90	risk	risk	NN
cord-006229-7yoilsho	3008	91	assessment	assessment	NN
cord-006229-7yoilsho	3008	92	approaches	approach	NNS
cord-006229-7yoilsho	3008	93	based	base	VBN
cord-006229-7yoilsho	3008	94	on	on	IN
cord-006229-7yoilsho	3008	95	target	target	NN
cord-006229-7yoilsho	3008	96	tissues	tissue	NNS
cord-006229-7yoilsho	3008	97	seems	seem	VBZ
cord-006229-7yoilsho	3008	98	overpredictive	overpredictive	JJ
cord-006229-7yoilsho	3008	99	,	,	,
cord-006229-7yoilsho	3008	100	whereas	whereas	IN
cord-006229-7yoilsho	3008	101	plasma	plasma	NN
cord-006229-7yoilsho	3008	102	related	relate	VBN
cord-006229-7yoilsho	3008	103	LOELs	loel	NNS
cord-006229-7yoilsho	3008	104	were	be	VBD
cord-006229-7yoilsho	3008	105	closer	close	JJR
cord-006229-7yoilsho	3008	106	to	to	IN
cord-006229-7yoilsho	3008	107	the	the	DT
cord-006229-7yoilsho	3008	108	in	in	IN
cord-006229-7yoilsho	3008	109	vivo	vivo	NN
cord-006229-7yoilsho	3008	110	situation	situation	NN
cord-006229-7yoilsho	3008	111	,	,	,
cord-006229-7yoilsho	3008	112	To	to	TO
cord-006229-7yoilsho	3008	113	study	study	VB
cord-006229-7yoilsho	3008	114	the	the	DT
cord-006229-7yoilsho	3008	115	activation	activation	NN
cord-006229-7yoilsho	3008	116	of	of	IN
cord-006229-7yoilsho	3008	117	the	the	DT
cord-006229-7yoilsho	3008	118	nuclear	nuclear	JJ
cord-006229-7yoilsho	3008	119	receptor	receptor	NN
cord-006229-7yoilsho	3008	120	PXR	PXR	NNP
cord-006229-7yoilsho	3008	121	a	a	DT
cord-006229-7yoilsho	3008	122	GAL4	GAL4	NNP
cord-006229-7yoilsho	3008	123	/	/	SYM
cord-006229-7yoilsho	3008	124	UAS	UAS	NNP
cord-006229-7yoilsho	3008	125	-	-	HYPH
cord-006229-7yoilsho	3008	126	based	base	VBN
cord-006229-7yoilsho	3008	127	PXR	PXR	NNP
cord-006229-7yoilsho	3008	128	transactivation	transactivation	NN
cord-006229-7yoilsho	3008	129	assay	assay	NN
cord-006229-7yoilsho	3008	130	was	be	VBD
cord-006229-7yoilsho	3008	131	used	use	VBN
cord-006229-7yoilsho	3008	132	.	.	.
cord-006229-7yoilsho	3009	1	The	the	DT
cord-006229-7yoilsho	3009	2	PXR	pxr	NN
cord-006229-7yoilsho	3009	3	-	-	HYPH
cord-006229-7yoilsho	3009	4	mediated	mediate	VBN
cord-006229-7yoilsho	3009	5	induction	induction	NN
cord-006229-7yoilsho	3009	6	of	of	IN
cord-006229-7yoilsho	3009	7	CYP3A4	cyp3a4	JJ
cord-006229-7yoilsho	3009	8	promotor	promotor	NN
cord-006229-7yoilsho	3009	9	activity	activity	NN
cord-006229-7yoilsho	3009	10	was	be	VBD
cord-006229-7yoilsho	3009	11	investigated	investigate	VBN
cord-006229-7yoilsho	3009	12	using	use	VBG
cord-006229-7yoilsho	3009	13	a	a	DT
cord-006229-7yoilsho	3009	14	PXR	pxr	NN
cord-006229-7yoilsho	3009	15	-	-	HYPH
cord-006229-7yoilsho	3009	16	dependent	dependent	JJ
cord-006229-7yoilsho	3009	17	CYP3A4	cyp3a4	JJ
cord-006229-7yoilsho	3009	18	reporter	reporter	NN
cord-006229-7yoilsho	3009	19	gene	gene	NN
cord-006229-7yoilsho	3009	20	assay	assay	NN
cord-006229-7yoilsho	3009	21	.	.	.
cord-006229-7yoilsho	3010	1	CYP3A4	CYP3A4	NNP
cord-006229-7yoilsho	3010	2	induction	induction	NN
cord-006229-7yoilsho	3010	3	was	be	VBD
cord-006229-7yoilsho	3010	4	analyzed	analyze	VBN
cord-006229-7yoilsho	3010	5	at	at	IN
cord-006229-7yoilsho	3010	6	the	the	DT
cord-006229-7yoilsho	3010	7	mRNA	mrna	NN
cord-006229-7yoilsho	3010	8	and	and	CC
cord-006229-7yoilsho	3010	9	protein	protein	NN
cord-006229-7yoilsho	3010	10	levels	level	NNS
cord-006229-7yoilsho	3010	11	in	in	IN
cord-006229-7yoilsho	3010	12	HepG2	HepG2	NNP
cord-006229-7yoilsho	3010	13	cells	cell	NNS
cord-006229-7yoilsho	3010	14	using	use	VBG
cord-006229-7yoilsho	3010	15	qPCR	qpcr	NN
cord-006229-7yoilsho	3010	16	and	and	CC
cord-006229-7yoilsho	3010	17	Western	western	JJ
cord-006229-7yoilsho	3010	18	Blot	blot	NN
cord-006229-7yoilsho	3010	19	.	.	.
cord-006229-7yoilsho	3011	1	To	to	TO
cord-006229-7yoilsho	3011	2	cover	cover	VB
cord-006229-7yoilsho	3011	3	the	the	DT
cord-006229-7yoilsho	3011	4	most	most	RBS
cord-006229-7yoilsho	3011	5	frequently	frequently	RB
cord-006229-7yoilsho	3011	6	occurring	occur	VBG
cord-006229-7yoilsho	3011	7	PA	PA	NNP
cord-006229-7yoilsho	3011	8	structures	structure	NNS
cord-006229-7yoilsho	3011	9	(	(	-LRB-
cord-006229-7yoilsho	3011	10	retronecine	retronecine	NNP
cord-006229-7yoilsho	3011	11	,	,	,
cord-006229-7yoilsho	3011	12	heliotridine	heliotridine	NNP
cord-006229-7yoilsho	3011	13	and	and	CC
cord-006229-7yoilsho	3011	14	otonecine	otonecine	NN
cord-006229-7yoilsho	3011	15	type	type	NN
cord-006229-7yoilsho	3011	16	as	as	RB
cord-006229-7yoilsho	3011	17	well	well	RB
cord-006229-7yoilsho	3011	18	as	as	IN
cord-006229-7yoilsho	3011	19	monoester	monoester	NNP
cord-006229-7yoilsho	3011	20	,	,	,
cord-006229-7yoilsho	3011	21	open	open	JJ
cord-006229-7yoilsho	3011	22	-	-	HYPH
cord-006229-7yoilsho	3011	23	chain	chain	NN
cord-006229-7yoilsho	3011	24	diester	diester	NN
cord-006229-7yoilsho	3011	25	and	and	CC
cord-006229-7yoilsho	3011	26	cyclic	cyclic	JJ
cord-006229-7yoilsho	3011	27	diester	diester	NN
cord-006229-7yoilsho	3011	28	)	)	-RRB-
cord-006229-7yoilsho	3011	29	the	the	DT
cord-006229-7yoilsho	3011	30	four	four	CD
cord-006229-7yoilsho	3011	31	PA	PA	NNP
cord-006229-7yoilsho	3011	32	senecionine	senecionine	NN
cord-006229-7yoilsho	3011	33	,	,	,
cord-006229-7yoilsho	3011	34	heliotrine	heliotrine	NNP
cord-006229-7yoilsho	3011	35	,	,	,
cord-006229-7yoilsho	3011	36	echimidine	echimidine	NNP
cord-006229-7yoilsho	3011	37	and	and	CC
cord-006229-7yoilsho	3011	38	senkirkine	senkirkine	NNP
cord-006229-7yoilsho	3011	39	were	be	VBD
cord-006229-7yoilsho	3011	40	selected	select	VBN
cord-006229-7yoilsho	3011	41	as	as	IN
cord-006229-7yoilsho	3011	42	representative	representative	JJ
cord-006229-7yoilsho	3011	43	PA	PA	NNP
cord-006229-7yoilsho	3011	44	for	for	IN
cord-006229-7yoilsho	3011	45	initial	initial	JJ
cord-006229-7yoilsho	3011	46	analyses	analysis	NNS
cord-006229-7yoilsho	3011	47	.	.	.
cord-006229-7yoilsho	3012	1	Out	out	IN
cord-006229-7yoilsho	3012	2	of	of	IN
cord-006229-7yoilsho	3012	3	the	the	DT
cord-006229-7yoilsho	3012	4	four	four	CD
cord-006229-7yoilsho	3012	5	investigated	investigate	VBN
cord-006229-7yoilsho	3012	6	PA	PA	NNP
cord-006229-7yoilsho	3012	7	only	only	RB
cord-006229-7yoilsho	3012	8	echimidine	echimidine	NNP
cord-006229-7yoilsho	3012	9	activated	activate	VBD
cord-006229-7yoilsho	3012	10	PXR	PXR	NNP
cord-006229-7yoilsho	3012	11	.	.	.
cord-006229-7yoilsho	3013	1	Accordingly	accordingly	RB
cord-006229-7yoilsho	3013	2	,	,	,
cord-006229-7yoilsho	3013	3	PXRmediated	pxrmediated	JJ
cord-006229-7yoilsho	3013	4	induction	induction	NN
cord-006229-7yoilsho	3013	5	of	of	IN
cord-006229-7yoilsho	3013	6	CYP3A4	cyp3a4	JJ
cord-006229-7yoilsho	3013	7	promotor	promotor	NN
cord-006229-7yoilsho	3013	8	activity	activity	NN
cord-006229-7yoilsho	3013	9	could	could	MD
cord-006229-7yoilsho	3013	10	only	only	RB
cord-006229-7yoilsho	3013	11	be	be	VB
cord-006229-7yoilsho	3013	12	detected	detect	VBN
cord-006229-7yoilsho	3013	13	for	for	IN
cord-006229-7yoilsho	3013	14	echimidine	echimidine	NN
cord-006229-7yoilsho	3013	15	.	.	.
cord-006229-7yoilsho	3014	1	CYP3A4	CYP3A4	NNP
cord-006229-7yoilsho	3014	2	induction	induction	NN
cord-006229-7yoilsho	3014	3	by	by	IN
cord-006229-7yoilsho	3014	4	echimidine	echimidine	NNP
cord-006229-7yoilsho	3014	5	was	be	VBD
cord-006229-7yoilsho	3014	6	verified	verify	VBN
cord-006229-7yoilsho	3014	7	at	at	IN
cord-006229-7yoilsho	3014	8	the	the	DT
cord-006229-7yoilsho	3014	9	mRNA	mrna	NN
cord-006229-7yoilsho	3014	10	and	and	CC
cord-006229-7yoilsho	3014	11	protein	protein	NN
cord-006229-7yoilsho	3014	12	level	level	NN
cord-006229-7yoilsho	3014	13	in	in	IN
cord-006229-7yoilsho	3014	14	HepG2	HepG2	NNP
cord-006229-7yoilsho	3014	15	wildtype	wildtype	NN
cord-006229-7yoilsho	3014	16	and	and	CC
cord-006229-7yoilsho	3014	17	HepG2	HepG2	NNP
cord-006229-7yoilsho	3014	18	PXR	PXR	NNP
cord-006229-7yoilsho	3014	19	-	-	HYPH
cord-006229-7yoilsho	3014	20	overexpressing	overexpresse	VBG
cord-006229-7yoilsho	3014	21	cells	cell	NNS
cord-006229-7yoilsho	3014	22	.	.	.
cord-006229-7yoilsho	3015	1	Taking	take	VBG
cord-006229-7yoilsho	3015	2	Heinrich	Heinrich	NNP
cord-006229-7yoilsho	3015	3	-	-	HYPH
cord-006229-7yoilsho	3015	4	Heine	Heine	NNP
cord-006229-7yoilsho	3015	5	Universität	Universität	NNP
cord-006229-7yoilsho	3015	6	Düsseldorf	Düsseldorf	NNP
cord-006229-7yoilsho	3015	7	,	,	,
cord-006229-7yoilsho	3015	8	Institut	Institut	NNP
cord-006229-7yoilsho	3015	9	für	für	IN
cord-006229-7yoilsho	3015	10	Toxikologie	Toxikologie	NNP
cord-006229-7yoilsho	3015	11	,	,	,
cord-006229-7yoilsho	3015	12	Düsseldorf	Düsseldorf	NNP
cord-006229-7yoilsho	3015	13	,	,	,
cord-006229-7yoilsho	3016	1	Germany	Germany	NNP
cord-006229-7yoilsho	3016	2	Introduction	Introduction	NNP
cord-006229-7yoilsho	3016	3	:	:	:
cord-006229-7yoilsho	3017	1	In	in	IN
cord-006229-7yoilsho	3017	2	higher	high	JJR
cord-006229-7yoilsho	3017	3	concentrations	concentration	NNS
cord-006229-7yoilsho	3017	4	,	,	,
cord-006229-7yoilsho	3017	5	the	the	DT
cord-006229-7yoilsho	3017	6	blood	blood	NN
cord-006229-7yoilsho	3017	7	pressure	pressure	NN
cord-006229-7yoilsho	3017	8	regulating	regulate	VBG
cord-006229-7yoilsho	3017	9	hormone	hormone	NN
cord-006229-7yoilsho	3017	10	angiotensin	angiotensin	NNP
cord-006229-7yoilsho	3017	11	II	II	NNP
cord-006229-7yoilsho	3017	12	(	(	-LRB-
cord-006229-7yoilsho	3017	13	Ang	Ang	NNP
cord-006229-7yoilsho	3017	14	II	II	NNP
cord-006229-7yoilsho	3017	15	)	)	-RRB-
cord-006229-7yoilsho	3017	16	,	,	,
cord-006229-7yoilsho	3017	17	leads	lead	VBZ
cord-006229-7yoilsho	3017	18	to	to	IN
cord-006229-7yoilsho	3017	19	vasoconstriction	vasoconstriction	NN
cord-006229-7yoilsho	3017	20	,	,	,
cord-006229-7yoilsho	3017	21	hypertension	hypertension	NN
cord-006229-7yoilsho	3017	22	and	and	CC
cord-006229-7yoilsho	3017	23	oxidative	oxidative	JJ
cord-006229-7yoilsho	3017	24	stress	stress	NN
cord-006229-7yoilsho	3017	25	by	by	IN
cord-006229-7yoilsho	3017	26	activation	activation	NN
cord-006229-7yoilsho	3017	27	of	of	IN
cord-006229-7yoilsho	3017	28	the	the	DT
cord-006229-7yoilsho	3017	29	renin	renin	NN
cord-006229-7yoilsho	3017	30	angiotensin	angiotensin	NNP
cord-006229-7yoilsho	3017	31	system	system	NN
cord-006229-7yoilsho	3017	32	(	(	-LRB-
cord-006229-7yoilsho	3017	33	RAS	RAS	NNP
cord-006229-7yoilsho	3017	34	)	)	-RRB-
cord-006229-7yoilsho	3017	35	.	.	.
cord-006229-7yoilsho	3018	1	Here	here	RB
cord-006229-7yoilsho	3018	2	we	-PRON-	PRP
cord-006229-7yoilsho	3018	3	investigate	investigate	VBP
cord-006229-7yoilsho	3018	4	if	if	IN
cord-006229-7yoilsho	3018	5	NADPHoxidases	nadphoxidase	NNS
cord-006229-7yoilsho	3018	6	are	be	VBP
cord-006229-7yoilsho	3018	7	responsible	responsible	JJ
cord-006229-7yoilsho	3018	8	for	for	IN
cord-006229-7yoilsho	3018	9	RAS	RAS	NNP
cord-006229-7yoilsho	3018	10	-	-	HYPH
cord-006229-7yoilsho	3018	11	mediated	mediate	VBN
cord-006229-7yoilsho	3018	12	oxidative	oxidative	JJ
cord-006229-7yoilsho	3018	13	stress	stress	NN
cord-006229-7yoilsho	3018	14	in	in	IN
cord-006229-7yoilsho	3018	15	kidney	kidney	NN
cord-006229-7yoilsho	3018	16	and	and	CC
cord-006229-7yoilsho	3018	17	heart	heart	NN
cord-006229-7yoilsho	3018	18	.	.	.
cord-006229-7yoilsho	3019	1	NADPH	NADPH	NNP
cord-006229-7yoilsho	3019	2	-	-	HYPH
cord-006229-7yoilsho	3019	3	oxidases	oxidase	NNS
cord-006229-7yoilsho	3019	4	(	(	-LRB-
cord-006229-7yoilsho	3019	5	7	7	CD
cord-006229-7yoilsho	3019	6	isoforms	isoform	NNS
cord-006229-7yoilsho	3019	7	are	be	VBP
cord-006229-7yoilsho	3019	8	known	know	VBN
cord-006229-7yoilsho	3019	9	,	,	,
cord-006229-7yoilsho	3019	10	Nox	Nox	NNP
cord-006229-7yoilsho	3019	11	1	1	CD
cord-006229-7yoilsho	3019	12	-	-	SYM
cord-006229-7yoilsho	3019	13	5	5	CD
cord-006229-7yoilsho	3019	14	,	,	,
cord-006229-7yoilsho	3019	15	Duox	Duox	NNP
cord-006229-7yoilsho	3019	16	1	1	CD
cord-006229-7yoilsho	3019	17	&	&	CC
cord-006229-7yoilsho	3019	18	2	2	CD
cord-006229-7yoilsho	3019	19	)	)	-RRB-
cord-006229-7yoilsho	3019	20	are	be	VBP
cord-006229-7yoilsho	3019	21	membrane	membrane	NN
cord-006229-7yoilsho	3019	22	-	-	HYPH
cord-006229-7yoilsho	3019	23	bound	bind	VBN
cord-006229-7yoilsho	3019	24	enzymes	enzyme	NNS
cord-006229-7yoilsho	3019	25	that	that	WDT
cord-006229-7yoilsho	3019	26	produce	produce	VBP
cord-006229-7yoilsho	3019	27	reactive	reactive	JJ
cord-006229-7yoilsho	3019	28	oxygen	oxygen	NN
cord-006229-7yoilsho	3019	29	species	specie	NNS
cord-006229-7yoilsho	3019	30	(	(	-LRB-
cord-006229-7yoilsho	3019	31	ROS	ROS	NNP
cord-006229-7yoilsho	3019	32	)	)	-RRB-
cord-006229-7yoilsho	3019	33	for	for	IN
cord-006229-7yoilsho	3019	34	example	example	NN
cord-006229-7yoilsho	3019	35	during	during	IN
cord-006229-7yoilsho	3019	36	the	the	DT
cord-006229-7yoilsho	3019	37	immune	immune	JJ
cord-006229-7yoilsho	3019	38	response	response	NN
cord-006229-7yoilsho	3019	39	and	and	CC
cord-006229-7yoilsho	3019	40	cell	cell	NN
cord-006229-7yoilsho	3019	41	signaling	signaling	NN
cord-006229-7yoilsho	3019	42	.	.	.
cord-006229-7yoilsho	3020	1	Material	material	NN
cord-006229-7yoilsho	3020	2	and	and	CC
cord-006229-7yoilsho	3020	3	Methods	method	NNS
cord-006229-7yoilsho	3020	4	:	:	:
cord-006229-7yoilsho	3020	5	To	to	TO
cord-006229-7yoilsho	3020	6	clarify	clarify	VB
cord-006229-7yoilsho	3020	7	the	the	DT
cord-006229-7yoilsho	3020	8	role	role	NN
cord-006229-7yoilsho	3020	9	of	of	IN
cord-006229-7yoilsho	3020	10	NADPH	nadph	NN
cord-006229-7yoilsho	3020	11	-	-	HYPH
cord-006229-7yoilsho	3020	12	oxidases	oxidase	NNS
cord-006229-7yoilsho	3020	13	,	,	,
cord-006229-7yoilsho	3020	14	wildtype	wildtype	NN
cord-006229-7yoilsho	3020	15	mice	mouse	NNS
cord-006229-7yoilsho	3020	16	and	and	CC
cord-006229-7yoilsho	3020	17	Nox	Nox	NNP
cord-006229-7yoilsho	3020	18	1-	1-	NNP
cord-006229-7yoilsho	3020	19	,	,	,
cord-006229-7yoilsho	3020	20	Nox	Nox	NNP
cord-006229-7yoilsho	3020	21	2-and	2-and	CD
cord-006229-7yoilsho	3020	22	Nox	Nox	NNP
cord-006229-7yoilsho	3021	1	4-deficient	4-deficient	CD
cord-006229-7yoilsho	3021	2	mice	mouse	NNS
cord-006229-7yoilsho	3021	3	were	be	VBD
cord-006229-7yoilsho	3021	4	equipped	equip	VBN
cord-006229-7yoilsho	3021	5	with	with	IN
cord-006229-7yoilsho	3021	6	osmotic	osmotic	JJ
cord-006229-7yoilsho	3021	7	minipumps	minipump	NNS
cord-006229-7yoilsho	3021	8	,	,	,
cord-006229-7yoilsho	3021	9	delivering	deliver	VBG
cord-006229-7yoilsho	3021	10	Ang	Ang	NNP
cord-006229-7yoilsho	3021	11	II	II	NNP
cord-006229-7yoilsho	3021	12	in	in	IN
cord-006229-7yoilsho	3021	13	a	a	DT
cord-006229-7yoilsho	3021	14	concentration	concentration	NN
cord-006229-7yoilsho	3021	15	of	of	IN
cord-006229-7yoilsho	3021	16	600	600	CD
cord-006229-7yoilsho	3021	17	ng	ng	NN
cord-006229-7yoilsho	3021	18	/	/	SYM
cord-006229-7yoilsho	3021	19	kg	kg	NNS
cord-006229-7yoilsho	3021	20	during	during	IN
cord-006229-7yoilsho	3021	21	28	28	CD
cord-006229-7yoilsho	3021	22	days	day	NNS
cord-006229-7yoilsho	3021	23	to	to	TO
cord-006229-7yoilsho	3021	24	stimulate	stimulate	VB
cord-006229-7yoilsho	3021	25	high	high	JJ
cord-006229-7yoilsho	3021	26	blood	blood	NN
cord-006229-7yoilsho	3021	27	pressure	pressure	NN
cord-006229-7yoilsho	3021	28	.	.	.
cord-006229-7yoilsho	3022	1	Kidney	kidney	NN
cord-006229-7yoilsho	3022	2	and	and	CC
cord-006229-7yoilsho	3022	3	heart	heart	NN
cord-006229-7yoilsho	3022	4	were	be	VBD
cord-006229-7yoilsho	3022	5	investigated	investigate	VBN
cord-006229-7yoilsho	3022	6	for	for	IN
cord-006229-7yoilsho	3022	7	steady	steady	JJ
cord-006229-7yoilsho	3022	8	-	-	HYPH
cord-006229-7yoilsho	3022	9	state	state	NN
cord-006229-7yoilsho	3022	10	ROS	ROS	NNP
cord-006229-7yoilsho	3022	11	levels	level	NNS
cord-006229-7yoilsho	3022	12	and	and	CC
cord-006229-7yoilsho	3022	13	DNA	dna	NN
cord-006229-7yoilsho	3022	14	damage	damage	NN
cord-006229-7yoilsho	3022	15	(	(	-LRB-
cord-006229-7yoilsho	3022	16	DNA	dna	NN
cord-006229-7yoilsho	3022	17	single	single	JJ
cord-006229-7yoilsho	3022	18	and	and	CC
cord-006229-7yoilsho	3022	19	double	double	JJ
cord-006229-7yoilsho	3022	20	strand	strand	NN
cord-006229-7yoilsho	3022	21	breaks	break	NNS
cord-006229-7yoilsho	3022	22	)	)	-RRB-
cord-006229-7yoilsho	3022	23	.	.	.
cord-006229-7yoilsho	3023	1	Results	result	NNS
cord-006229-7yoilsho	3023	2	:	:	:
cord-006229-7yoilsho	3024	1	In	in	IN
cord-006229-7yoilsho	3024	2	wildtype	wildtype	JJ
cord-006229-7yoilsho	3024	3	mice	mouse	NNS
cord-006229-7yoilsho	3024	4	,	,	,
cord-006229-7yoilsho	3024	5	Ang	Ang	NNP
cord-006229-7yoilsho	3024	6	II	II	NNP
cord-006229-7yoilsho	3024	7	leads	lead	VBZ
cord-006229-7yoilsho	3024	8	to	to	IN
cord-006229-7yoilsho	3024	9	hypertension	hypertension	NN
cord-006229-7yoilsho	3024	10	,	,	,
cord-006229-7yoilsho	3024	11	a	a	DT
cord-006229-7yoilsho	3024	12	declined	decline	VBN
cord-006229-7yoilsho	3024	13	renal	renal	JJ
cord-006229-7yoilsho	3024	14	function	function	NN
cord-006229-7yoilsho	3024	15	,	,	,
cord-006229-7yoilsho	3024	16	formation	formation	NN
cord-006229-7yoilsho	3024	17	of	of	IN
cord-006229-7yoilsho	3024	18	ROS	ROS	NNP
cord-006229-7yoilsho	3024	19	in	in	IN
cord-006229-7yoilsho	3024	20	kidney	kidney	NN
cord-006229-7yoilsho	3024	21	and	and	CC
cord-006229-7yoilsho	3024	22	heart	heart	NN
cord-006229-7yoilsho	3024	23	and	and	CC
cord-006229-7yoilsho	3024	24	to	to	IN
cord-006229-7yoilsho	3024	25	DNA	DNA	NNP
cord-006229-7yoilsho	3025	1	single	single	JJ
cord-006229-7yoilsho	3025	2	and	and	CC
cord-006229-7yoilsho	3025	3	double	double	JJ
cord-006229-7yoilsho	3025	4	strand	strand	NN
cord-006229-7yoilsho	3025	5	breaks	break	NNS
cord-006229-7yoilsho	3025	6	in	in	IN
cord-006229-7yoilsho	3025	7	the	the	DT
cord-006229-7yoilsho	3025	8	kidney	kidney	NN
cord-006229-7yoilsho	3025	9	.	.	.
cord-006229-7yoilsho	3026	1	All	all	DT
cord-006229-7yoilsho	3026	2	Nox	Nox	NNP
cord-006229-7yoilsho	3026	3	-	-	HYPH
cord-006229-7yoilsho	3026	4	knockout	knockout	NN
cord-006229-7yoilsho	3026	5	mice	mouse	NNS
cord-006229-7yoilsho	3026	6	exhibited	exhibit	VBD
cord-006229-7yoilsho	3026	7	Ang	Ang	NNP
cord-006229-7yoilsho	3026	8	II	II	NNP
cord-006229-7yoilsho	3026	9	-	-	HYPH
cord-006229-7yoilsho	3026	10	mediated	mediate	VBN
cord-006229-7yoilsho	3026	11	hypertension	hypertension	NN
cord-006229-7yoilsho	3026	12	and	and	CC
cord-006229-7yoilsho	3026	13	albuminuria	albuminuria	NNS
cord-006229-7yoilsho	3026	14	.	.	.
cord-006229-7yoilsho	3027	1	The	the	DT
cord-006229-7yoilsho	3027	2	lack	lack	NN
cord-006229-7yoilsho	3027	3	of	of	IN
cord-006229-7yoilsho	3027	4	Nox	Nox	NNP
cord-006229-7yoilsho	3027	5	2	2	CD
cord-006229-7yoilsho	3027	6	and	and	CC
cord-006229-7yoilsho	3027	7	Nox	Nox	NNP
cord-006229-7yoilsho	3027	8	4	4	CD
cord-006229-7yoilsho	3027	9	could	could	MD
cord-006229-7yoilsho	3027	10	neither	neither	CC
cord-006229-7yoilsho	3027	11	protect	protect	VB
cord-006229-7yoilsho	3027	12	from	from	IN
cord-006229-7yoilsho	3027	13	the	the	DT
cord-006229-7yoilsho	3027	14	formation	formation	NN
cord-006229-7yoilsho	3027	15	of	of	IN
cord-006229-7yoilsho	3027	16	oxidative	oxidative	JJ
cord-006229-7yoilsho	3027	17	stress	stress	NN
cord-006229-7yoilsho	3027	18	in	in	IN
cord-006229-7yoilsho	3027	19	the	the	DT
cord-006229-7yoilsho	3027	20	kindey	kindey	NNP
cord-006229-7yoilsho	3027	21	nor	nor	CC
cord-006229-7yoilsho	3027	22	from	from	IN
cord-006229-7yoilsho	3027	23	DNA	DNA	NNP
cord-006229-7yoilsho	3027	24	double	double	JJ
cord-006229-7yoilsho	3027	25	strand	strand	NN
cord-006229-7yoilsho	3027	26	breaks	break	NNS
cord-006229-7yoilsho	3027	27	in	in	IN
cord-006229-7yoilsho	3027	28	the	the	DT
cord-006229-7yoilsho	3027	29	kidney	kidney	NN
cord-006229-7yoilsho	3027	30	.	.	.
cord-006229-7yoilsho	3028	1	Initial	initial	JJ
cord-006229-7yoilsho	3028	2	findings	finding	NNS
cord-006229-7yoilsho	3028	3	from	from	IN
cord-006229-7yoilsho	3028	4	the	the	DT
cord-006229-7yoilsho	3028	5	Nox	Nox	NNP
cord-006229-7yoilsho	3028	6	1-knockout	1-knockout	CD
cord-006229-7yoilsho	3028	7	mouse	mouse	NN
cord-006229-7yoilsho	3028	8	do	do	VBP
cord-006229-7yoilsho	3028	9	not	not	RB
cord-006229-7yoilsho	3028	10	show	show	VB
cord-006229-7yoilsho	3028	11	an	an	DT
cord-006229-7yoilsho	3028	12	increase	increase	NN
cord-006229-7yoilsho	3028	13	in	in	IN
cord-006229-7yoilsho	3028	14	DNA	dna	NN
cord-006229-7yoilsho	3028	15	double	double	JJ
cord-006229-7yoilsho	3028	16	strand	strand	NN
cord-006229-7yoilsho	3028	17	breaks	break	NNS
cord-006229-7yoilsho	3028	18	in	in	IN
cord-006229-7yoilsho	3028	19	the	the	DT
cord-006229-7yoilsho	3028	20	kidney	kidney	NN
cord-006229-7yoilsho	3028	21	.	.	.
cord-006229-7yoilsho	3029	1	Discussion	discussion	NN
cord-006229-7yoilsho	3029	2	:	:	:
cord-006229-7yoilsho	3030	1	Contrary	contrary	JJ
cord-006229-7yoilsho	3030	2	to	to	IN
cord-006229-7yoilsho	3030	3	published	publish	VBN
cord-006229-7yoilsho	3030	4	results	result	NNS
cord-006229-7yoilsho	3030	5	of	of	IN
cord-006229-7yoilsho	3030	6	Nox	Nox	NNP
cord-006229-7yoilsho	3030	7	1-knockout	1-knockout	CD
cord-006229-7yoilsho	3030	8	mice	mouse	NNS
cord-006229-7yoilsho	3030	9	,	,	,
cord-006229-7yoilsho	3030	10	we	-PRON-	PRP
cord-006229-7yoilsho	3030	11	observed	observe	VBD
cord-006229-7yoilsho	3030	12	a	a	DT
cord-006229-7yoilsho	3030	13	constant	constant	JJ
cord-006229-7yoilsho	3030	14	rise	rise	NN
cord-006229-7yoilsho	3030	15	in	in	IN
cord-006229-7yoilsho	3030	16	blood	blood	NN
cord-006229-7yoilsho	3030	17	pressure	pressure	NN
cord-006229-7yoilsho	3030	18	over	over	IN
cord-006229-7yoilsho	3030	19	the	the	DT
cord-006229-7yoilsho	3030	20	treatment	treatment	NN
cord-006229-7yoilsho	3030	21	period	period	NN
cord-006229-7yoilsho	3030	22	compared	compare	VBN
cord-006229-7yoilsho	3030	23	to	to	IN
cord-006229-7yoilsho	3030	24	the	the	DT
cord-006229-7yoilsho	3030	25	control	control	NN
cord-006229-7yoilsho	3030	26	.	.	.
cord-006229-7yoilsho	3031	1	This	this	DT
cord-006229-7yoilsho	3031	2	can	can	MD
cord-006229-7yoilsho	3031	3	possibly	possibly	RB
cord-006229-7yoilsho	3031	4	be	be	VB
cord-006229-7yoilsho	3031	5	due	due	JJ
cord-006229-7yoilsho	3031	6	to	to	IN
cord-006229-7yoilsho	3031	7	different	different	JJ
cord-006229-7yoilsho	3031	8	Ang	Ang	NNP
cord-006229-7yoilsho	3031	9	II	II	NNP
cord-006229-7yoilsho	3031	10	doses	dose	NNS
cord-006229-7yoilsho	3031	11	.	.	.
cord-006229-7yoilsho	3032	1	In	in	IN
cord-006229-7yoilsho	3032	2	Nox	Nox	NNP
cord-006229-7yoilsho	3032	3	4-knockout	4-knockout	CD
cord-006229-7yoilsho	3032	4	mice	mouse	NNS
cord-006229-7yoilsho	3032	5	we	-PRON-	PRP
cord-006229-7yoilsho	3032	6	observed	observe	VBD
cord-006229-7yoilsho	3032	7	increased	increase	VBD
cord-006229-7yoilsho	3032	8	oxidative	oxidative	JJ
cord-006229-7yoilsho	3032	9	stress	stress	NN
cord-006229-7yoilsho	3032	10	and	and	CC
cord-006229-7yoilsho	3032	11	increased	increase	VBN
cord-006229-7yoilsho	3032	12	renal	renal	JJ
cord-006229-7yoilsho	3032	13	DNA	dna	NN
cord-006229-7yoilsho	3032	14	damage	damage	NN
cord-006229-7yoilsho	3032	15	already	already	RB
cord-006229-7yoilsho	3032	16	in	in	IN
cord-006229-7yoilsho	3032	17	untreated	untreated	JJ
cord-006229-7yoilsho	3032	18	control	control	NN
cord-006229-7yoilsho	3032	19	animals	animal	NNS
cord-006229-7yoilsho	3032	20	,	,	,
cord-006229-7yoilsho	3032	21	which	which	WDT
cord-006229-7yoilsho	3032	22	is	be	VBZ
cord-006229-7yoilsho	3032	23	in	in	IN
cord-006229-7yoilsho	3032	24	line	line	NN
cord-006229-7yoilsho	3032	25	with	with	IN
cord-006229-7yoilsho	3032	26	reports	report	NNS
cord-006229-7yoilsho	3032	27	suggesting	suggest	VBG
cord-006229-7yoilsho	3032	28	a	a	DT
cord-006229-7yoilsho	3032	29	protective	protective	JJ
cord-006229-7yoilsho	3032	30	effect	effect	NN
cord-006229-7yoilsho	3032	31	of	of	IN
cord-006229-7yoilsho	3032	32	Nox4	Nox4	NNP
cord-006229-7yoilsho	3032	33	.	.	.
cord-006229-7yoilsho	3033	1	Conclusion	conclusion	NN
cord-006229-7yoilsho	3033	2	:	:	:
cord-006229-7yoilsho	3034	1	Separate	separate	JJ
cord-006229-7yoilsho	3034	2	eliminations	elimination	NNS
cord-006229-7yoilsho	3034	3	of	of	IN
cord-006229-7yoilsho	3034	4	3	3	CD
cord-006229-7yoilsho	3034	5	NADPH	NADPH	NNP
cord-006229-7yoilsho	3034	6	-	-	HYPH
cord-006229-7yoilsho	3034	7	isoforms	isoform	NNS
cord-006229-7yoilsho	3034	8	did	do	VBD
cord-006229-7yoilsho	3034	9	not	not	RB
cord-006229-7yoilsho	3034	10	allow	allow	VB
cord-006229-7yoilsho	3034	11	the	the	DT
cord-006229-7yoilsho	3034	12	identification	identification	NN
cord-006229-7yoilsho	3034	13	of	of	IN
cord-006229-7yoilsho	3034	14	the	the	DT
cord-006229-7yoilsho	3034	15	enzyme	enzyme	NN
cord-006229-7yoilsho	3034	16	which	which	WDT
cord-006229-7yoilsho	3034	17	is	be	VBZ
cord-006229-7yoilsho	3034	18	responsible	responsible	JJ
cord-006229-7yoilsho	3034	19	for	for	IN
cord-006229-7yoilsho	3034	20	Ang	Ang	NNP
cord-006229-7yoilsho	3034	21	II	II	NNP
cord-006229-7yoilsho	3034	22	-	-	HYPH
cord-006229-7yoilsho	3034	23	induced	induce	VBN
cord-006229-7yoilsho	3034	24	oxidative	oxidative	JJ
cord-006229-7yoilsho	3034	25	stress	stress	NN
cord-006229-7yoilsho	3034	26	.	.	.
cord-006229-7yoilsho	3035	1	A	a	DT
cord-006229-7yoilsho	3035	2	possible	possible	JJ
cord-006229-7yoilsho	3035	3	explanation	explanation	NN
cord-006229-7yoilsho	3035	4	is	be	VBZ
cord-006229-7yoilsho	3035	5	that	that	IN
cord-006229-7yoilsho	3035	6	oxidative	oxidative	JJ
cord-006229-7yoilsho	3035	7	stress	stress	NN
cord-006229-7yoilsho	3035	8	is	be	VBZ
cord-006229-7yoilsho	3035	9	caused	cause	VBN
cord-006229-7yoilsho	3035	10	by	by	IN
cord-006229-7yoilsho	3035	11	more	more	JJR
cord-006229-7yoilsho	3035	12	than	than	IN
cord-006229-7yoilsho	3035	13	one	one	CD
cord-006229-7yoilsho	3035	14	Nox	Nox	NNP
cord-006229-7yoilsho	3035	15	-	-	HYPH
cord-006229-7yoilsho	3035	16	isoform	isoform	NN
cord-006229-7yoilsho	3035	17	or	or	CC
cord-006229-7yoilsho	3035	18	other	other	JJ
cord-006229-7yoilsho	3035	19	enzymes	enzyme	NNS
cord-006229-7yoilsho	3035	20	like	like	IN
cord-006229-7yoilsho	3035	21	xanthine	xanthine	NN
cord-006229-7yoilsho	3035	22	oxidase	oxidase	NN
cord-006229-7yoilsho	3035	23	or	or	CC
cord-006229-7yoilsho	3035	24	nitrogen	nitrogen	NN
cord-006229-7yoilsho	3035	25	synthase	synthase	NN
cord-006229-7yoilsho	3035	26	take	take	VB
cord-006229-7yoilsho	3035	27	major	major	JJ
cord-006229-7yoilsho	3035	28	part	part	NN
cord-006229-7yoilsho	3035	29	in	in	IN
cord-006229-7yoilsho	3035	30	the	the	DT
cord-006229-7yoilsho	3035	31	formation	formation	NN
cord-006229-7yoilsho	3035	32	of	of	IN
cord-006229-7yoilsho	3035	33	ROS	ROS	NNP
cord-006229-7yoilsho	3035	34	.	.	.
cord-006229-7yoilsho	3036	1	Of	of	IN
cord-006229-7yoilsho	3036	2	mice	mouse	NNS
cord-006229-7yoilsho	3036	3	(	(	-LRB-
cord-006229-7yoilsho	3036	4	rats	rat	NNS
cord-006229-7yoilsho	3036	5	,	,	,
cord-006229-7yoilsho	3036	6	cats	cat	NNS
cord-006229-7yoilsho	3036	7	,	,	,
cord-006229-7yoilsho	3036	8	dogs	dog	NNS
cord-006229-7yoilsho	3036	9	,	,	,
cord-006229-7yoilsho	3036	10	monkey	monkey	NN
cord-006229-7yoilsho	3036	11	)	)	-RRB-
cord-006229-7yoilsho	3036	12	and	and	CC
cord-006229-7yoilsho	3036	13	men	man	NNS
cord-006229-7yoilsho	3036	14	-how	-how	:
cord-006229-7yoilsho	3036	15	to	to	TO
cord-006229-7yoilsho	3036	16	measure	measure	VB
cord-006229-7yoilsho	3036	17	kidney	kidney	NN
cord-006229-7yoilsho	3036	18	biomarkers	biomarker	NNS
cord-006229-7yoilsho	3036	19	across	across	IN
cord-006229-7yoilsho	3036	20	species	specie	NNS
cord-006229-7yoilsho	3036	21	Introduction	introduction	NN
cord-006229-7yoilsho	3036	22	and	and	CC
cord-006229-7yoilsho	3036	23	Objectives	Objectives	NNPS
cord-006229-7yoilsho	3036	24	:	:	:
cord-006229-7yoilsho	3036	25	There	there	EX
cord-006229-7yoilsho	3036	26	is	be	VBZ
cord-006229-7yoilsho	3036	27	a	a	DT
cord-006229-7yoilsho	3036	28	need	need	NN
cord-006229-7yoilsho	3036	29	for	for	IN
cord-006229-7yoilsho	3036	30	reliable	reliable	JJ
cord-006229-7yoilsho	3036	31	biomarker	biomarker	NN
cord-006229-7yoilsho	3036	32	assays	assay	NNS
cord-006229-7yoilsho	3036	33	to	to	TO
cord-006229-7yoilsho	3036	34	detect	detect	VB
cord-006229-7yoilsho	3036	35	organ	organ	NN
cord-006229-7yoilsho	3036	36	toxicity	toxicity	NN
cord-006229-7yoilsho	3036	37	induced	induce	VBN
cord-006229-7yoilsho	3036	38	by	by	IN
cord-006229-7yoilsho	3036	39	drug	drug	NN
cord-006229-7yoilsho	3036	40	candidates	candidate	NNS
cord-006229-7yoilsho	3036	41	.	.	.
cord-006229-7yoilsho	3037	1	In	in	IN
cord-006229-7yoilsho	3037	2	the	the	DT
cord-006229-7yoilsho	3037	3	last	last	JJ
cord-006229-7yoilsho	3037	4	50	50	CD
cord-006229-7yoilsho	3037	5	years	year	NNS
cord-006229-7yoilsho	3037	6	about	about	RB
cord-006229-7yoilsho	3037	7	60	60	CD
cord-006229-7yoilsho	3037	8	drugs	drug	NNS
cord-006229-7yoilsho	3037	9	were	be	VBD
cord-006229-7yoilsho	3037	10	withdrawn	withdraw	VBN
cord-006229-7yoilsho	3037	11	from	from	IN
cord-006229-7yoilsho	3037	12	the	the	DT
cord-006229-7yoilsho	3037	13	market	market	NN
cord-006229-7yoilsho	3037	14	due	due	JJ
cord-006229-7yoilsho	3037	15	to	to	IN
cord-006229-7yoilsho	3037	16	liver	liver	NN
cord-006229-7yoilsho	3037	17	and/or	and/or	CC
cord-006229-7yoilsho	3037	18	kidney	kidney	NN
cord-006229-7yoilsho	3037	19	damage	damage	NN
cord-006229-7yoilsho	3037	20	.	.	.
cord-006229-7yoilsho	3038	1	For	for	IN
cord-006229-7yoilsho	3038	2	the	the	DT
cord-006229-7yoilsho	3038	3	detection	detection	NN
cord-006229-7yoilsho	3038	4	of	of	IN
cord-006229-7yoilsho	3038	5	druginduced	druginduced	JJ
cord-006229-7yoilsho	3038	6	organ	organ	NN
cord-006229-7yoilsho	3038	7	injury	injury	NN
cord-006229-7yoilsho	3038	8	,	,	,
cord-006229-7yoilsho	3038	9	safety	safety	NN
cord-006229-7yoilsho	3038	10	-	-	HYPH
cord-006229-7yoilsho	3038	11	tox	tox	NN
cord-006229-7yoilsho	3038	12	studies	study	NNS
cord-006229-7yoilsho	3038	13	in	in	IN
cord-006229-7yoilsho	3038	14	rodents	rodent	NNS
cord-006229-7yoilsho	3038	15	,	,	,
cord-006229-7yoilsho	3038	16	dogs	dog	NNS
cord-006229-7yoilsho	3038	17	,	,	,
cord-006229-7yoilsho	3038	18	non	non	JJ
cord-006229-7yoilsho	3038	19	-	-	JJ
cord-006229-7yoilsho	3038	20	human	human	JJ
cord-006229-7yoilsho	3038	21	primates	primate	NNS
cord-006229-7yoilsho	3038	22	and	and	CC
cord-006229-7yoilsho	3038	23	humans	human	NNS
cord-006229-7yoilsho	3038	24	are	be	VBP
cord-006229-7yoilsho	3038	25	mandatory	mandatory	JJ
cord-006229-7yoilsho	3038	26	in	in	IN
cord-006229-7yoilsho	3038	27	the	the	DT
cord-006229-7yoilsho	3038	28	drug	drug	NN
cord-006229-7yoilsho	3038	29	development	development	NN
cord-006229-7yoilsho	3038	30	process	process	NN
cord-006229-7yoilsho	3038	31	.	.	.
cord-006229-7yoilsho	3039	1	Currently	currently	RB
cord-006229-7yoilsho	3039	2	,	,	,
cord-006229-7yoilsho	3039	3	several	several	JJ
cord-006229-7yoilsho	3039	4	protein	protein	NN
cord-006229-7yoilsho	3039	5	biomarkers	biomarker	NNS
cord-006229-7yoilsho	3039	6	for	for	IN
cord-006229-7yoilsho	3039	7	kidney	kidney	NN
cord-006229-7yoilsho	3039	8	,	,	,
cord-006229-7yoilsho	3039	9	liver	liver	NN
cord-006229-7yoilsho	3039	10	and	and	CC
cord-006229-7yoilsho	3039	11	cardiovascular	cardiovascular	JJ
cord-006229-7yoilsho	3039	12	organ	organ	NN
cord-006229-7yoilsho	3039	13	toxicitity	toxicitity	NN
cord-006229-7yoilsho	3039	14	are	be	VBP
cord-006229-7yoilsho	3039	15	being	be	VBG
cord-006229-7yoilsho	3039	16	clinically	clinically	RB
cord-006229-7yoilsho	3039	17	validated	validate	VBN
cord-006229-7yoilsho	3039	18	by	by	IN
cord-006229-7yoilsho	3039	19	international	international	JJ
cord-006229-7yoilsho	3039	20	consortia	consortium	NNS
cord-006229-7yoilsho	3039	21	like	like	IN
cord-006229-7yoilsho	3039	22	the	the	DT
cord-006229-7yoilsho	3039	23	Safer	Safer	NNP
cord-006229-7yoilsho	3039	24	and	and	CC
cord-006229-7yoilsho	3039	25	Faster	fast	JJR
cord-006229-7yoilsho	3039	26	Evidence	evidence	NN
cord-006229-7yoilsho	3039	27	-	-	HYPH
cord-006229-7yoilsho	3039	28	based	base	VBN
cord-006229-7yoilsho	3039	29	Translation	translation	NN
cord-006229-7yoilsho	3039	30	(	(	-LRB-
cord-006229-7yoilsho	3039	31	SAFE	SAFE	NNP
cord-006229-7yoilsho	3039	32	-	-	HYPH
cord-006229-7yoilsho	3039	33	T	T	NNP
cord-006229-7yoilsho	3039	34	)	)	-RRB-
cord-006229-7yoilsho	3039	35	or	or	CC
cord-006229-7yoilsho	3039	36	the	the	DT
cord-006229-7yoilsho	3039	37	Predictive	Predictive	NNP
cord-006229-7yoilsho	3039	38	Safety	Safety	NNP
cord-006229-7yoilsho	3039	39	Consortium	Consortium	NNP
cord-006229-7yoilsho	3039	40	(	(	-LRB-
cord-006229-7yoilsho	3039	41	PSTC	PSTC	NNP
cord-006229-7yoilsho	3039	42	)	)	-RRB-
cord-006229-7yoilsho	3039	43	.	.	.
cord-006229-7yoilsho	3040	1	We	-PRON-	PRP
cord-006229-7yoilsho	3040	2	are	be	VBP
cord-006229-7yoilsho	3040	3	developing	develop	VBG
cord-006229-7yoilsho	3040	4	mass	mass	JJ
cord-006229-7yoilsho	3040	5	-	-	HYPH
cord-006229-7yoilsho	3040	6	spectrometry	spectrometry	NN
cord-006229-7yoilsho	3040	7	-	-	HYPH
cord-006229-7yoilsho	3040	8	based	base	VBN
cord-006229-7yoilsho	3040	9	immuoassays	immuoassay	NNS
cord-006229-7yoilsho	3040	10	suitable	suitable	JJ
cord-006229-7yoilsho	3040	11	for	for	IN
cord-006229-7yoilsho	3040	12	the	the	DT
cord-006229-7yoilsho	3040	13	detection	detection	NN
cord-006229-7yoilsho	3040	14	of	of	IN
cord-006229-7yoilsho	3040	15	these	these	DT
cord-006229-7yoilsho	3040	16	markers	marker	NNS
cord-006229-7yoilsho	3040	17	in	in	IN
cord-006229-7yoilsho	3040	18	animal	animal	NN
cord-006229-7yoilsho	3040	19	models	model	NNS
cord-006229-7yoilsho	3040	20	to	to	TO
cord-006229-7yoilsho	3040	21	support	support	VB
cord-006229-7yoilsho	3040	22	these	these	DT
cord-006229-7yoilsho	3040	23	efforts	effort	NNS
cord-006229-7yoilsho	3040	24	Method	method	NN
cord-006229-7yoilsho	3040	25	:	:	:
cord-006229-7yoilsho	3040	26	Urinary	urinary	JJ
cord-006229-7yoilsho	3040	27	proteins	protein	NNS
cord-006229-7yoilsho	3040	28	are	be	VBP
cord-006229-7yoilsho	3040	29	proteolytically	proteolytically	RB
cord-006229-7yoilsho	3040	30	digested	digest	VBN
cord-006229-7yoilsho	3040	31	to	to	IN
cord-006229-7yoilsho	3040	32	peptides	peptide	NNS
cord-006229-7yoilsho	3040	33	using	use	VBG
cord-006229-7yoilsho	3040	34	trypsin	trypsin	NN
cord-006229-7yoilsho	3040	35	.	.	.
cord-006229-7yoilsho	3041	1	Subsequently	subsequently	RB
cord-006229-7yoilsho	3041	2	synthetic	synthetic	JJ
cord-006229-7yoilsho	3041	3	isotope	isotope	NN
cord-006229-7yoilsho	3041	4	-	-	HYPH
cord-006229-7yoilsho	3041	5	labelled	label	VBN
cord-006229-7yoilsho	3041	6	peptide	peptide	JJ
cord-006229-7yoilsho	3041	7	standards	standard	NNS
cord-006229-7yoilsho	3041	8	are	be	VBP
cord-006229-7yoilsho	3041	9	spiked	spike	VBN
cord-006229-7yoilsho	3041	10	in	in	RP
cord-006229-7yoilsho	3041	11	at	at	IN
cord-006229-7yoilsho	3041	12	known	know	VBN
cord-006229-7yoilsho	3041	13	concentrations	concentration	NNS
cord-006229-7yoilsho	3041	14	.	.	.
cord-006229-7yoilsho	3042	1	We	-PRON-	PRP
cord-006229-7yoilsho	3042	2	employ	employ	VBP
cord-006229-7yoilsho	3042	3	multi	multi	JJ
cord-006229-7yoilsho	3042	4	-	-	JJ
cord-006229-7yoilsho	3042	5	specific	specific	JJ
cord-006229-7yoilsho	3042	6	antibodies	antibody	NNS
cord-006229-7yoilsho	3042	7	(	(	-LRB-
cord-006229-7yoilsho	3042	8	TXP	TXP	NNP
cord-006229-7yoilsho	3042	9	-	-	HYPH
cord-006229-7yoilsho	3042	10	antibodies	antibody	NNS
cord-006229-7yoilsho	3042	11	)	)	-RRB-
cord-006229-7yoilsho	3042	12	targeting	target	VBG
cord-006229-7yoilsho	3042	13	Cterminal	cterminal	JJ
cord-006229-7yoilsho	3042	14	amino	amino	NN
cord-006229-7yoilsho	3042	15	acid	acid	NN
cord-006229-7yoilsho	3042	16	motifs	motif	NNS
cord-006229-7yoilsho	3042	17	for	for	IN
cord-006229-7yoilsho	3042	18	the	the	DT
cord-006229-7yoilsho	3042	19	enrichment	enrichment	NN
cord-006229-7yoilsho	3042	20	of	of	IN
cord-006229-7yoilsho	3042	21	peptides	peptide	NNS
cord-006229-7yoilsho	3042	22	derived	derive	VBN
cord-006229-7yoilsho	3042	23	from	from	IN
cord-006229-7yoilsho	3042	24	the	the	DT
cord-006229-7yoilsho	3042	25	protein	protein	NN
cord-006229-7yoilsho	3042	26	biomarkers	biomarker	NNS
cord-006229-7yoilsho	3042	27	.	.	.
cord-006229-7yoilsho	3043	1	Finally	finally	RB
cord-006229-7yoilsho	3043	2	,	,	,
cord-006229-7yoilsho	3043	3	the	the	DT
cord-006229-7yoilsho	3043	4	protein	protein	NN
cord-006229-7yoilsho	3043	5	biomarkers	biomarker	NNS
cord-006229-7yoilsho	3043	6	are	be	VBP
cord-006229-7yoilsho	3043	7	quantified	quantify	VBN
cord-006229-7yoilsho	3043	8	using	use	VBG
cord-006229-7yoilsho	3043	9	nanoLC	nanoLC	NNP
cord-006229-7yoilsho	3043	10	-	-	HYPH
cord-006229-7yoilsho	3043	11	Parallel	Parallel	NNP
cord-006229-7yoilsho	3043	12	Reaction	Reaction	NNP
cord-006229-7yoilsho	3043	13	Monitoring	Monitoring	NNP
cord-006229-7yoilsho	3043	14	-	-	HYPH
cord-006229-7yoilsho	3043	15	MS	MS	NNP
cord-006229-7yoilsho	3043	16	.	.	.
cord-006229-7yoilsho	3044	1	The	the	DT
cord-006229-7yoilsho	3044	2	use	use	NN
cord-006229-7yoilsho	3044	3	of	of	IN
cord-006229-7yoilsho	3044	4	our	-PRON-	PRP$
cord-006229-7yoilsho	3044	5	group	group	NN
cord-006229-7yoilsho	3044	6	-	-	HYPH
cord-006229-7yoilsho	3044	7	specific	specific	JJ
cord-006229-7yoilsho	3044	8	TXP	TXP	NNP
cord-006229-7yoilsho	3044	9	-	-	HYPH
cord-006229-7yoilsho	3044	10	antibodies	antibody	NNS
cord-006229-7yoilsho	3044	11	allows	allow	VBZ
cord-006229-7yoilsho	3044	12	protein	protein	NN
cord-006229-7yoilsho	3044	13	analysis	analysis	NN
cord-006229-7yoilsho	3044	14	of	of	IN
cord-006229-7yoilsho	3044	15	samples	sample	NNS
cord-006229-7yoilsho	3044	16	from	from	IN
cord-006229-7yoilsho	3044	17	different	different	JJ
cord-006229-7yoilsho	3044	18	species	specie	NNS
cord-006229-7yoilsho	3044	19	using	use	VBG
cord-006229-7yoilsho	3044	20	the	the	DT
cord-006229-7yoilsho	3044	21	same	same	JJ
cord-006229-7yoilsho	3044	22	antibody	antibody	NN
cord-006229-7yoilsho	3044	23	.	.	.
cord-006229-7yoilsho	3045	1	Results	result	NNS
cord-006229-7yoilsho	3045	2	and	and	CC
cord-006229-7yoilsho	3045	3	Discussion	discussion	NN
cord-006229-7yoilsho	3046	1	:	:	:
cord-006229-7yoilsho	3046	2	We	-PRON-	PRP
cord-006229-7yoilsho	3046	3	established	establish	VBD
cord-006229-7yoilsho	3046	4	an	an	DT
cord-006229-7yoilsho	3046	5	MS	MS	NNP
cord-006229-7yoilsho	3046	6	-	-	HYPH
cord-006229-7yoilsho	3046	7	based	base	VBN
cord-006229-7yoilsho	3046	8	Immunoassay	Immunoassay	NNP
cord-006229-7yoilsho	3046	9	platform	platform	NN
cord-006229-7yoilsho	3046	10	for	for	IN
cord-006229-7yoilsho	3046	11	the	the	DT
cord-006229-7yoilsho	3046	12	analysis	analysis	NN
cord-006229-7yoilsho	3046	13	of	of	IN
cord-006229-7yoilsho	3046	14	kidney	kidney	NN
cord-006229-7yoilsho	3046	15	(	(	-LRB-
cord-006229-7yoilsho	3046	16	DIKI	DIKI	NNP
cord-006229-7yoilsho	3046	17	)	)	-RRB-
cord-006229-7yoilsho	3046	18	injury	injury	NN
cord-006229-7yoilsho	3046	19	protein	protein	NN
cord-006229-7yoilsho	3046	20	biomarkers	biomarker	NNS
cord-006229-7yoilsho	3046	21	in	in	IN
cord-006229-7yoilsho	3046	22	urine	urine	NN
cord-006229-7yoilsho	3046	23	across	across	IN
cord-006229-7yoilsho	3046	24	5	5	CD
cord-006229-7yoilsho	3046	25	species	specie	NNS
cord-006229-7yoilsho	3046	26	;	;	,
cord-006229-7yoilsho	3046	27	human	human	JJ
cord-006229-7yoilsho	3046	28	,	,	,
cord-006229-7yoilsho	3046	29	cynomolgus	cynomolgus	JJ
cord-006229-7yoilsho	3046	30	,	,	,
cord-006229-7yoilsho	3046	31	mouse	mouse	NN
cord-006229-7yoilsho	3046	32	,	,	,
cord-006229-7yoilsho	3046	33	rat	rat	NN
cord-006229-7yoilsho	3046	34	and	and	CC
cord-006229-7yoilsho	3046	35	dog	dog	NN
cord-006229-7yoilsho	3046	36	.	.	.
cord-006229-7yoilsho	3047	1	We	-PRON-	PRP
cord-006229-7yoilsho	3047	2	analyzed	analyze	VBD
cord-006229-7yoilsho	3047	3	the	the	DT
cord-006229-7yoilsho	3047	4	potential	potential	JJ
cord-006229-7yoilsho	3047	5	DIKI	DIKI	NNP
cord-006229-7yoilsho	3047	6	biomarkers	biomarker	NNS
cord-006229-7yoilsho	3047	7	aquaporin	aquaporin	NNP
cord-006229-7yoilsho	3047	8	2	2	NNP
cord-006229-7yoilsho	3047	9	,	,	,
cord-006229-7yoilsho	3047	10	podocin	podocin	NNS
cord-006229-7yoilsho	3047	11	,	,	,
cord-006229-7yoilsho	3047	12	synaptopodin	synaptopodin	NN
cord-006229-7yoilsho	3047	13	,	,	,
cord-006229-7yoilsho	3047	14	retinol	retinol	NN
cord-006229-7yoilsho	3047	15	-	-	HYPH
cord-006229-7yoilsho	3047	16	binding	bind	VBG
cord-006229-7yoilsho	3047	17	protein	protein	NN
cord-006229-7yoilsho	3047	18	4	4	CD
cord-006229-7yoilsho	3047	19	,	,	,
cord-006229-7yoilsho	3047	20	clusterin	clusterin	NNP
cord-006229-7yoilsho	3047	21	and	and	CC
cord-006229-7yoilsho	3047	22	osteopontin	osteopontin	NN
cord-006229-7yoilsho	3047	23	in	in	IN
cord-006229-7yoilsho	3047	24	urine	urine	NN
cord-006229-7yoilsho	3047	25	samples	sample	NNS
cord-006229-7yoilsho	3047	26	from	from	IN
cord-006229-7yoilsho	3047	27	toxicity	toxicity	NN
cord-006229-7yoilsho	3047	28	studies	study	NNS
cord-006229-7yoilsho	3047	29	in	in	IN
cord-006229-7yoilsho	3047	30	cynomolgus	cynomolgus	JJ
cord-006229-7yoilsho	3047	31	monkeys	monkey	NNS
cord-006229-7yoilsho	3047	32	,	,	,
cord-006229-7yoilsho	3047	33	rodents	rodent	NNS
cord-006229-7yoilsho	3047	34	and	and	CC
cord-006229-7yoilsho	3047	35	humans	human	NNS
cord-006229-7yoilsho	3047	36	.	.	.
cord-006229-7yoilsho	3048	1	Conclusion	conclusion	NN
cord-006229-7yoilsho	3048	2	:	:	:
cord-006229-7yoilsho	3049	1	The	the	DT
cord-006229-7yoilsho	3049	2	application	application	NN
cord-006229-7yoilsho	3049	3	of	of	IN
cord-006229-7yoilsho	3049	4	group	group	NN
cord-006229-7yoilsho	3049	5	-	-	HYPH
cord-006229-7yoilsho	3049	6	specific	specific	JJ
cord-006229-7yoilsho	3049	7	TXP	TXP	NNP
cord-006229-7yoilsho	3049	8	-	-	HYPH
cord-006229-7yoilsho	3049	9	antibodies	antibody	NNS
cord-006229-7yoilsho	3049	10	and	and	CC
cord-006229-7yoilsho	3049	11	mass	mass	NN
cord-006229-7yoilsho	3049	12	spectrometry	spectrometry	NN
cord-006229-7yoilsho	3049	13	allows	allow	VBZ
cord-006229-7yoilsho	3049	14	the	the	DT
cord-006229-7yoilsho	3049	15	quantification	quantification	NN
cord-006229-7yoilsho	3049	16	of	of	IN
cord-006229-7yoilsho	3049	17	biomarkers	biomarker	NNS
cord-006229-7yoilsho	3049	18	in	in	IN
cord-006229-7yoilsho	3049	19	urine	urine	NN
cord-006229-7yoilsho	3049	20	of	of	IN
cord-006229-7yoilsho	3049	21	all	all	DT
cord-006229-7yoilsho	3049	22	relevant	relevant	JJ
cord-006229-7yoilsho	3049	23	model	model	NN
cord-006229-7yoilsho	3049	24	organisms	organism	NNS
cord-006229-7yoilsho	3049	25	.	.	.
cord-006229-7yoilsho	3050	1	The	the	DT
cord-006229-7yoilsho	3050	2	results	result	NNS
cord-006229-7yoilsho	3050	3	strongly	strongly	RB
cord-006229-7yoilsho	3050	4	support	support	VBP
cord-006229-7yoilsho	3050	5	the	the	DT
cord-006229-7yoilsho	3050	6	validation	validation	NN
cord-006229-7yoilsho	3050	7	of	of	IN
cord-006229-7yoilsho	3050	8	translational	translational	JJ
cord-006229-7yoilsho	3050	9	drug	drug	NN
cord-006229-7yoilsho	3050	10	-	-	HYPH
cord-006229-7yoilsho	3050	11	induced	induce	VBN
cord-006229-7yoilsho	3050	12	organ	organ	NN
cord-006229-7yoilsho	3050	13	injury	injury	NN
cord-006229-7yoilsho	3050	14	protein	protein	NN
cord-006229-7yoilsho	3050	15	biomarkers	biomarker	NNS
cord-006229-7yoilsho	3050	16	.	.	.
cord-006229-7yoilsho	3051	1	Although	although	IN
cord-006229-7yoilsho	3051	2	effective	effective	JJ
cord-006229-7yoilsho	3051	3	anticancer	anticancer	NN
cord-006229-7yoilsho	3051	4	-	-	HYPH
cord-006229-7yoilsho	3051	5	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	3051	6	regimen	regimen	NN
cord-006229-7yoilsho	3051	7	are	be	VBP
cord-006229-7yoilsho	3051	8	available	available	JJ
cord-006229-7yoilsho	3051	9	,	,	,
cord-006229-7yoilsho	3051	10	they	-PRON-	PRP
cord-006229-7yoilsho	3051	11	are	be	VBP
cord-006229-7yoilsho	3051	12	accompanied	accompany	VBN
cord-006229-7yoilsho	3051	13	by	by	IN
cord-006229-7yoilsho	3051	14	severe	severe	JJ
cord-006229-7yoilsho	3051	15	adverse	adverse	JJ
cord-006229-7yoilsho	3051	16	effects	effect	NNS
cord-006229-7yoilsho	3051	17	on	on	IN
cord-006229-7yoilsho	3051	18	normal	normal	JJ
cord-006229-7yoilsho	3051	19	tissue	tissue	NN
cord-006229-7yoilsho	3051	20	,	,	,
cord-006229-7yoilsho	3051	21	for	for	IN
cord-006229-7yoilsho	3051	22	instance	instance	NN
cord-006229-7yoilsho	3051	23	chemotherapy	chemotherapy	NN
cord-006229-7yoilsho	3051	24	induced	induce	VBN
cord-006229-7yoilsho	3051	25	peripheral	peripheral	JJ
cord-006229-7yoilsho	3051	26	neuropathy	neuropathy	NN
cord-006229-7yoilsho	3051	27	(	(	-LRB-
cord-006229-7yoilsho	3051	28	CIPN	CIPN	NNP
cord-006229-7yoilsho	3051	29	)	)	-RRB-
cord-006229-7yoilsho	3051	30	caused	cause	VBN
cord-006229-7yoilsho	3051	31	by	by	IN
cord-006229-7yoilsho	3051	32	platinum	platinum	NN
cord-006229-7yoilsho	3051	33	compounds	compound	NNS
cord-006229-7yoilsho	3051	34	.	.	.
cord-006229-7yoilsho	3052	1	The	the	DT
cord-006229-7yoilsho	3052	2	pathophysiology	pathophysiology	NN
cord-006229-7yoilsho	3052	3	of	of	IN
cord-006229-7yoilsho	3052	4	this	this	DT
cord-006229-7yoilsho	3052	5	clinically	clinically	RB
cord-006229-7yoilsho	3052	6	highly	highly	RB
cord-006229-7yoilsho	3052	7	relevant	relevant	JJ
cord-006229-7yoilsho	3052	8	side	side	NN
cord-006229-7yoilsho	3052	9	-	-	HYPH
cord-006229-7yoilsho	3052	10	effect	effect	NN
cord-006229-7yoilsho	3052	11	is	be	VBZ
cord-006229-7yoilsho	3052	12	still	still	RB
cord-006229-7yoilsho	3052	13	unknown	unknown	JJ
cord-006229-7yoilsho	3052	14	and	and	CC
cord-006229-7yoilsho	3052	15	neither	neither	CC
cord-006229-7yoilsho	3052	16	prophylaxis	prophylaxis	NN
cord-006229-7yoilsho	3052	17	nor	nor	CC
cord-006229-7yoilsho	3052	18	specific	specific	JJ
cord-006229-7yoilsho	3052	19	treatment	treatment	NN
cord-006229-7yoilsho	3052	20	is	be	VBZ
cord-006229-7yoilsho	3052	21	available	available	JJ
cord-006229-7yoilsho	3052	22	.	.	.
cord-006229-7yoilsho	3053	1	Therefore	therefore	RB
cord-006229-7yoilsho	3053	2	,	,	,
cord-006229-7yoilsho	3053	3	further	further	JJ
cord-006229-7yoilsho	3053	4	research	research	NN
cord-006229-7yoilsho	3053	5	elucidating	elucidate	VBG
cord-006229-7yoilsho	3053	6	the	the	DT
cord-006229-7yoilsho	3053	7	underlying	underlying	JJ
cord-006229-7yoilsho	3053	8	molecular	molecular	JJ
cord-006229-7yoilsho	3053	9	mechanisms	mechanism	NNS
cord-006229-7yoilsho	3053	10	of	of	IN
cord-006229-7yoilsho	3053	11	platinating	platinate	VBG
cord-006229-7yoilsho	3053	12	anti	anti	JJ
cord-006229-7yoilsho	3053	13	-	-	JJ
cord-006229-7yoilsho	3053	14	tumor	tumor	JJ
cord-006229-7yoilsho	3053	15	drugs	drug	NNS
cord-006229-7yoilsho	3053	16	leading	lead	VBG
cord-006229-7yoilsho	3053	17	to	to	IN
cord-006229-7yoilsho	3053	18	CIPN	CIPN	NNP
cord-006229-7yoilsho	3053	19	is	be	VBZ
cord-006229-7yoilsho	3053	20	required	require	VBN
cord-006229-7yoilsho	3053	21	as	as	IN
cord-006229-7yoilsho	3053	22	basis	basis	NN
cord-006229-7yoilsho	3053	23	for	for	IN
cord-006229-7yoilsho	3053	24	future	future	JJ
cord-006229-7yoilsho	3053	25	development	development	NN
cord-006229-7yoilsho	3053	26	of	of	IN
cord-006229-7yoilsho	3053	27	preventive	preventive	JJ
cord-006229-7yoilsho	3053	28	or	or	CC
cord-006229-7yoilsho	3053	29	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	3053	30	strategies	strategy	NNS
cord-006229-7yoilsho	3053	31	.	.	.
cord-006229-7yoilsho	3054	1	In	in	IN
cord-006229-7yoilsho	3054	2	general	general	JJ
cord-006229-7yoilsho	3054	3	,	,	,
cord-006229-7yoilsho	3054	4	platinum	platinum	NN
cord-006229-7yoilsho	3054	5	compounds	compound	NNS
cord-006229-7yoilsho	3054	6	lead	lead	VBP
cord-006229-7yoilsho	3054	7	to	to	IN
cord-006229-7yoilsho	3054	8	cell	cell	NN
cord-006229-7yoilsho	3054	9	death	death	NN
cord-006229-7yoilsho	3054	10	mainly	mainly	RB
cord-006229-7yoilsho	3054	11	via	via	IN
cord-006229-7yoilsho	3054	12	DNA	dna	NN
cord-006229-7yoilsho	3054	13	damage	damage	NN
cord-006229-7yoilsho	3054	14	induction	induction	NN
cord-006229-7yoilsho	3054	15	(	(	-LRB-
cord-006229-7yoilsho	3054	16	mostly	mostly	RB
cord-006229-7yoilsho	3054	17	intrastrandcrosslinks	intrastrandcrosslinks	NNP
cord-006229-7yoilsho	3054	18	)	)	-RRB-
cord-006229-7yoilsho	3054	19	and	and	CC
cord-006229-7yoilsho	3054	20	through	through	IN
cord-006229-7yoilsho	3054	21	interference	interference	NN
cord-006229-7yoilsho	3054	22	with	with	IN
cord-006229-7yoilsho	3054	23	the	the	DT
cord-006229-7yoilsho	3054	24	redox	redox	JJ
cord-006229-7yoilsho	3054	25	homeostasis	homeostasis	NN
cord-006229-7yoilsho	3054	26	of	of	IN
cord-006229-7yoilsho	3054	27	cells	cell	NNS
cord-006229-7yoilsho	3054	28	.	.	.
cord-006229-7yoilsho	3055	1	Here	here	RB
cord-006229-7yoilsho	3055	2	,	,	,
cord-006229-7yoilsho	3055	3	we	-PRON-	PRP
cord-006229-7yoilsho	3055	4	introduce	introduce	VBP
cord-006229-7yoilsho	3055	5	and	and	CC
cord-006229-7yoilsho	3055	6	suggest	suggest	VBP
cord-006229-7yoilsho	3055	7	the	the	DT
cord-006229-7yoilsho	3055	8	well	well	RB
cord-006229-7yoilsho	3055	9	-	-	HYPH
cord-006229-7yoilsho	3055	10	known	know	VBN
cord-006229-7yoilsho	3055	11	nematode	nematode	NN
cord-006229-7yoilsho	3055	12	model	model	NN
cord-006229-7yoilsho	3055	13	organism	organism	NN
cord-006229-7yoilsho	3055	14	C.	C.	NNP
cord-006229-7yoilsho	3055	15	elegans	elegan	NNS
cord-006229-7yoilsho	3055	16	to	to	TO
cord-006229-7yoilsho	3055	17	elucidate	elucidate	VB
cord-006229-7yoilsho	3055	18	mechanisms	mechanism	NNS
cord-006229-7yoilsho	3055	19	of	of	IN
cord-006229-7yoilsho	3055	20	neurotoxicity	neurotoxicity	NN
cord-006229-7yoilsho	3055	21	triggered	trigger	VBN
cord-006229-7yoilsho	3055	22	by	by	IN
cord-006229-7yoilsho	3055	23	platinating	platinate	VBG
cord-006229-7yoilsho	3055	24	agents	agent	NNS
cord-006229-7yoilsho	3055	25	.	.	.
cord-006229-7yoilsho	3056	1	So	so	RB
cord-006229-7yoilsho	3056	2	far	far	RB
cord-006229-7yoilsho	3056	3	,	,	,
cord-006229-7yoilsho	3056	4	we	-PRON-	PRP
cord-006229-7yoilsho	3056	5	determined	determine	VBD
cord-006229-7yoilsho	3056	6	doses	dose	NNS
cord-006229-7yoilsho	3056	7	for	for	IN
cord-006229-7yoilsho	3056	8	cis	cis	NNP
cord-006229-7yoilsho	3056	9	-	-	HYPH
cord-006229-7yoilsho	3056	10	and	and	CC
cord-006229-7yoilsho	3056	11	oxaliplatin	oxaliplatin	NNP
cord-006229-7yoilsho	3056	12	,	,	,
cord-006229-7yoilsho	3056	13	which	which	WDT
cord-006229-7yoilsho	3056	14	have	have	VBP
cord-006229-7yoilsho	3056	15	only	only	JJ
cord-006229-7yoilsho	3056	16	moderate	moderate	JJ
cord-006229-7yoilsho	3056	17	effects	effect	NNS
cord-006229-7yoilsho	3056	18	on	on	IN
cord-006229-7yoilsho	3056	19	development	development	NN
cord-006229-7yoilsho	3056	20	,	,	,
cord-006229-7yoilsho	3056	21	reproduction	reproduction	NN
cord-006229-7yoilsho	3056	22	and	and	CC
cord-006229-7yoilsho	3056	23	body	body	NN
cord-006229-7yoilsho	3056	24	movement	movement	NN
cord-006229-7yoilsho	3056	25	(	(	-LRB-
cord-006229-7yoilsho	3056	26	muscular	muscular	JJ
cord-006229-7yoilsho	3056	27	read	read	NN
cord-006229-7yoilsho	3056	28	-	-	HYPH
cord-006229-7yoilsho	3056	29	out	out	NN
cord-006229-7yoilsho	3056	30	)	)	-RRB-
cord-006229-7yoilsho	3056	31	.	.	.
cord-006229-7yoilsho	3057	1	However	however	RB
cord-006229-7yoilsho	3057	2	,	,	,
cord-006229-7yoilsho	3057	3	these	these	DT
cord-006229-7yoilsho	3057	4	doses	dose	NNS
cord-006229-7yoilsho	3057	5	are	be	VBP
cord-006229-7yoilsho	3057	6	sufficient	sufficient	JJ
cord-006229-7yoilsho	3057	7	to	to	TO
cord-006229-7yoilsho	3057	8	trigger	trigger	VB
cord-006229-7yoilsho	3057	9	apoptosis	apoptosis	NN
cord-006229-7yoilsho	3057	10	in	in	IN
cord-006229-7yoilsho	3057	11	C.	C.	NNP
cord-006229-7yoilsho	3057	12	elegans	elegan	NNS
cord-006229-7yoilsho	3057	13	and	and	CC
cord-006229-7yoilsho	3057	14	to	to	TO
cord-006229-7yoilsho	3057	15	induce	induce	VB
cord-006229-7yoilsho	3057	16	a	a	DT
cord-006229-7yoilsho	3057	17	considerable	considerable	JJ
cord-006229-7yoilsho	3057	18	amount	amount	NN
cord-006229-7yoilsho	3057	19	of	of	IN
cord-006229-7yoilsho	3057	20	1,2-intrastrand	1,2-intrastrand	CD
cord-006229-7yoilsho	3057	21	crosslinks	crosslink	NNS
cord-006229-7yoilsho	3057	22	in	in	IN
cord-006229-7yoilsho	3057	23	DNA	DNA	NNP
cord-006229-7yoilsho	3057	24	(	(	-LRB-
cord-006229-7yoilsho	3057	25	measured	measure	VBN
cord-006229-7yoilsho	3057	26	by	by	IN
cord-006229-7yoilsho	3057	27	south	south	JJ
cord-006229-7yoilsho	3057	28	-	-	HYPH
cord-006229-7yoilsho	3057	29	western	western	JJ
cord-006229-7yoilsho	3057	30	blotting	blotting	NN
cord-006229-7yoilsho	3057	31	)	)	-RRB-
cord-006229-7yoilsho	3057	32	.	.	.
cord-006229-7yoilsho	3058	1	Even	even	RB
cord-006229-7yoilsho	3058	2	more	more	RBR
cord-006229-7yoilsho	3058	3	important	important	JJ
cord-006229-7yoilsho	3058	4	they	-PRON-	PRP
cord-006229-7yoilsho	3058	5	lead	lead	VBP
cord-006229-7yoilsho	3058	6	to	to	IN
cord-006229-7yoilsho	3058	7	strong	strong	JJ
cord-006229-7yoilsho	3058	8	neurotoxicity	neurotoxicity	NN
cord-006229-7yoilsho	3058	9	in	in	IN
cord-006229-7yoilsho	3058	10	a	a	DT
cord-006229-7yoilsho	3058	11	functional	functional	JJ
cord-006229-7yoilsho	3058	12	read	read	NN
cord-006229-7yoilsho	3058	13	-	-	HYPH
cord-006229-7yoilsho	3058	14	out	out	NN
cord-006229-7yoilsho	3058	15	(	(	-LRB-
cord-006229-7yoilsho	3058	16	pharyngeal	pharyngeal	JJ
cord-006229-7yoilsho	3058	17	pumping	pumping	NN
cord-006229-7yoilsho	3058	18	)	)	-RRB-
cord-006229-7yoilsho	3058	19	.	.	.
cord-006229-7yoilsho	3059	1	With	with	IN
cord-006229-7yoilsho	3059	2	regard	regard	NN
cord-006229-7yoilsho	3059	3	to	to	IN
cord-006229-7yoilsho	3059	4	redox	redox	JJ
cord-006229-7yoilsho	3059	5	homeostasis	homeostasis	NN
cord-006229-7yoilsho	3059	6	,	,	,
cord-006229-7yoilsho	3059	7	we	-PRON-	PRP
cord-006229-7yoilsho	3059	8	determined	determine	VBD
cord-006229-7yoilsho	3059	9	the	the	DT
cord-006229-7yoilsho	3059	10	oxidative	oxidative	JJ
cord-006229-7yoilsho	3059	11	stress	stress	NN
cord-006229-7yoilsho	3059	12	resistance	resistance	NN
cord-006229-7yoilsho	3059	13	showing	show	VBG
cord-006229-7yoilsho	3059	14	that	that	DT
cord-006229-7yoilsho	3060	1	e.g.	e.g.	RB
cord-006229-7yoilsho	3060	2	cisplatin	cisplatin	RB
cord-006229-7yoilsho	3060	3	sensitizes	sensitize	VBZ
cord-006229-7yoilsho	3060	4	C.	C.	NNP
cord-006229-7yoilsho	3060	5	elegans	elegan	NNS
cord-006229-7yoilsho	3060	6	to	to	TO
cord-006229-7yoilsho	3060	7	reactive	reactive	JJ
cord-006229-7yoilsho	3060	8	oxygen	oxygen	NN
cord-006229-7yoilsho	3060	9	species	specie	NNS
cord-006229-7yoilsho	3060	10	(	(	-LRB-
cord-006229-7yoilsho	3060	11	ROS	ROS	NNP
cord-006229-7yoilsho	3060	12	)	)	-RRB-
cord-006229-7yoilsho	3060	13	,	,	,
cord-006229-7yoilsho	3060	14	which	which	WDT
cord-006229-7yoilsho	3060	15	could	could	MD
cord-006229-7yoilsho	3060	16	be	be	VB
cord-006229-7yoilsho	3060	17	prevented	prevent	VBN
cord-006229-7yoilsho	3060	18	if	if	IN
cord-006229-7yoilsho	3060	19	worms	worm	NNS
cord-006229-7yoilsho	3060	20	were	be	VBD
cord-006229-7yoilsho	3060	21	co	co	VBN
cord-006229-7yoilsho	3060	22	-	-	:
cord-006229-7yoilsho	3060	23	or	or	CC
cord-006229-7yoilsho	3060	24	pretreated	pretreate	VBN
cord-006229-7yoilsho	3060	25	with	with	IN
cord-006229-7yoilsho	3060	26	N	n	NN
cord-006229-7yoilsho	3060	27	-	-	HYPH
cord-006229-7yoilsho	3060	28	acetylcysteine	acetylcysteine	NN
cord-006229-7yoilsho	3060	29	.	.	.
cord-006229-7yoilsho	3061	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	3061	2	we	-PRON-	PRP
cord-006229-7yoilsho	3061	3	determined	determine	VBD
cord-006229-7yoilsho	3061	4	the	the	DT
cord-006229-7yoilsho	3061	5	level	level	NN
cord-006229-7yoilsho	3061	6	of	of	IN
cord-006229-7yoilsho	3061	7	ROS	ROS	NNP
cord-006229-7yoilsho	3061	8	in	in	IN
cord-006229-7yoilsho	3061	9	living	live	VBG
cord-006229-7yoilsho	3061	10	C.	C.	NNP
cord-006229-7yoilsho	3061	11	elegans	elegan	NNS
cord-006229-7yoilsho	3061	12	after	after	IN
cord-006229-7yoilsho	3061	13	treatment	treatment	NN
cord-006229-7yoilsho	3061	14	with	with	IN
cord-006229-7yoilsho	3061	15	platinating	platinating	NN
cord-006229-7yoilsho	3061	16	agents	agent	NNS
cord-006229-7yoilsho	3061	17	and	and	CC
cord-006229-7yoilsho	3061	18	also	also	RB
cord-006229-7yoilsho	3061	19	in	in	IN
cord-006229-7yoilsho	3061	20	combination	combination	NN
cord-006229-7yoilsho	3061	21	with	with	IN
cord-006229-7yoilsho	3061	22	protective	protective	JJ
cord-006229-7yoilsho	3061	23	compounds	compound	NNS
cord-006229-7yoilsho	3061	24	.	.	.
cord-006229-7yoilsho	3062	1	Using	use	VBG
cord-006229-7yoilsho	3062	2	the	the	DT
cord-006229-7yoilsho	3062	3	advantages	advantage	NNS
cord-006229-7yoilsho	3062	4	of	of	IN
cord-006229-7yoilsho	3062	5	C.	C.	NNP
cord-006229-7yoilsho	3062	6	elegans	elegan	NNS
cord-006229-7yoilsho	3062	7	as	as	IN
cord-006229-7yoilsho	3062	8	a	a	DT
cord-006229-7yoilsho	3062	9	genetic	genetic	JJ
cord-006229-7yoilsho	3062	10	model	model	NN
cord-006229-7yoilsho	3062	11	system	system	NN
cord-006229-7yoilsho	3062	12	,	,	,
cord-006229-7yoilsho	3062	13	we	-PRON-	PRP
cord-006229-7yoilsho	3062	14	will	will	MD
cord-006229-7yoilsho	3062	15	further	further	RB
cord-006229-7yoilsho	3062	16	clarify	clarify	VB
cord-006229-7yoilsho	3062	17	the	the	DT
cord-006229-7yoilsho	3062	18	relevance	relevance	NN
cord-006229-7yoilsho	3062	19	of	of	IN
cord-006229-7yoilsho	3062	20	different	different	JJ
cord-006229-7yoilsho	3062	21	defense	defense	NN
cord-006229-7yoilsho	3062	22	mechanisms	mechanism	NNS
cord-006229-7yoilsho	3062	23	,	,	,
cord-006229-7yoilsho	3062	24	including	include	VBG
cord-006229-7yoilsho	3062	25	DNA	dna	NN
cord-006229-7yoilsho	3062	26	repair	repair	NN
cord-006229-7yoilsho	3062	27	(	(	-LRB-
cord-006229-7yoilsho	3062	28	nucleotide	nucleotide	JJ
cord-006229-7yoilsho	3062	29	excision	excision	NN
cord-006229-7yoilsho	3062	30	repair	repair	NN
cord-006229-7yoilsho	3062	31	,	,	,
cord-006229-7yoilsho	3062	32	base	base	NN
cord-006229-7yoilsho	3062	33	excision	excision	NN
cord-006229-7yoilsho	3062	34	repair	repair	NN
cord-006229-7yoilsho	3062	35	)	)	-RRB-
cord-006229-7yoilsho	3062	36	,	,	,
cord-006229-7yoilsho	3062	37	detoxification	detoxification	NN
cord-006229-7yoilsho	3062	38	systems	system	NNS
cord-006229-7yoilsho	3062	39	(	(	-LRB-
cord-006229-7yoilsho	3062	40	antioxidative	antioxidative	JJ
cord-006229-7yoilsho	3062	41	stress	stress	NN
cord-006229-7yoilsho	3062	42	factors	factor	NNS
cord-006229-7yoilsho	3062	43	,	,	,
cord-006229-7yoilsho	3062	44	metallothioneins	metallothionein	NNS
cord-006229-7yoilsho	3062	45	)	)	-RRB-
cord-006229-7yoilsho	3062	46	as	as	RB
cord-006229-7yoilsho	3062	47	well	well	RB
cord-006229-7yoilsho	3062	48	as	as	IN
cord-006229-7yoilsho	3062	49	drug	drug	NN
cord-006229-7yoilsho	3062	50	transporters	transporter	NNS
cord-006229-7yoilsho	3062	51	and	and	CC
cord-006229-7yoilsho	3062	52	signaling	signal	VBG
cord-006229-7yoilsho	3062	53	proteins	protein	NNS
cord-006229-7yoilsho	3062	54	.	.	.
cord-006229-7yoilsho	3063	1	This	this	DT
cord-006229-7yoilsho	3063	2	will	will	MD
cord-006229-7yoilsho	3063	3	be	be	VB
cord-006229-7yoilsho	3063	4	achieved	achieve	VBN
cord-006229-7yoilsho	3063	5	by	by	IN
cord-006229-7yoilsho	3063	6	using	use	VBG
cord-006229-7yoilsho	3063	7	RNA	RNA	NNP
cord-006229-7yoilsho	3063	8	interference	interference	NN
cord-006229-7yoilsho	3063	9	approaches	approach	NNS
cord-006229-7yoilsho	3063	10	that	that	WDT
cord-006229-7yoilsho	3063	11	allow	allow	VBP
cord-006229-7yoilsho	3063	12	targeting	target	VBG
cord-006229-7yoilsho	3063	13	either	either	CC
cord-006229-7yoilsho	3063	14	the	the	DT
cord-006229-7yoilsho	3063	15	whole	whole	JJ
cord-006229-7yoilsho	3063	16	animal	animal	NN
cord-006229-7yoilsho	3063	17	or	or	CC
cord-006229-7yoilsho	3063	18	specific	specific	JJ
cord-006229-7yoilsho	3063	19	tissues	tissue	NNS
cord-006229-7yoilsho	3063	20	(	(	-LRB-
cord-006229-7yoilsho	3063	21	i.e.	i.e.	FW
cord-006229-7yoilsho	3063	22	neurons	neuron	NNS
cord-006229-7yoilsho	3063	23	)	)	-RRB-
cord-006229-7yoilsho	3063	24	only	only	RB
cord-006229-7yoilsho	3063	25	.	.	.
cord-006229-7yoilsho	3064	1	First	first	JJ
cord-006229-7yoilsho	3064	2	results	result	NNS
cord-006229-7yoilsho	3064	3	of	of	IN
cord-006229-7yoilsho	3064	4	this	this	DT
cord-006229-7yoilsho	3064	5	approach	approach	NN
cord-006229-7yoilsho	3064	6	will	will	MD
cord-006229-7yoilsho	3064	7	be	be	VB
cord-006229-7yoilsho	3064	8	presented	present	VBN
cord-006229-7yoilsho	3064	9	.	.	.
cord-006229-7yoilsho	3065	1	Finally	finally	RB
cord-006229-7yoilsho	3065	2	we	-PRON-	PRP
cord-006229-7yoilsho	3065	3	aim	aim	VBP
cord-006229-7yoilsho	3065	4	to	to	TO
cord-006229-7yoilsho	3065	5	use	use	VB
cord-006229-7yoilsho	3065	6	this	this	DT
cord-006229-7yoilsho	3065	7	setup	setup	NN
cord-006229-7yoilsho	3065	8	to	to	TO
cord-006229-7yoilsho	3065	9	identify	identify	VB
cord-006229-7yoilsho	3065	10	neuroprotective	neuroprotective	JJ
cord-006229-7yoilsho	3065	11	compounds	compound	NNS
cord-006229-7yoilsho	3065	12	that	that	WDT
cord-006229-7yoilsho	3065	13	prevent	prevent	VBP
cord-006229-7yoilsho	3065	14	chemotherapy	chemotherapy	NN
cord-006229-7yoilsho	3065	15	induced	induce	VBN
cord-006229-7yoilsho	3065	16	peripheral	peripheral	JJ
cord-006229-7yoilsho	3065	17	neuropathy	neuropathy	NN
cord-006229-7yoilsho	3065	18	induced	induce	VBN
cord-006229-7yoilsho	3065	19	by	by	IN
cord-006229-7yoilsho	3065	20	platinating	platinate	VBG
cord-006229-7yoilsho	3065	21	anti	anti	JJ
cord-006229-7yoilsho	3065	22	-	-	JJ
cord-006229-7yoilsho	3065	23	tumor	tumor	JJ
cord-006229-7yoilsho	3065	24	drugs	drug	NNS
cord-006229-7yoilsho	3065	25	.	.	.
cord-006229-7yoilsho	3066	1	Clostridium	clostridium	NN
cord-006229-7yoilsho	3066	2	botulinum	botulinum	NN
cord-006229-7yoilsho	3066	3	C3	c3	NN
cord-006229-7yoilsho	3066	4	exoenyzme	exoenyzme	NNS
cord-006229-7yoilsho	3066	5	(	(	-LRB-
cord-006229-7yoilsho	3066	6	C3	c3	NN
cord-006229-7yoilsho	3066	7	)	)	-RRB-
cord-006229-7yoilsho	3067	1	exclusively	exclusively	RB
cord-006229-7yoilsho	3067	2	ADP	ADP	NNP
cord-006229-7yoilsho	3067	3	-	-	HYPH
cord-006229-7yoilsho	3067	4	ribosylates	ribosylates	NNP
cord-006229-7yoilsho	3067	5	RhoA	RhoA	NNP
cord-006229-7yoilsho	3067	6	,	,	,
cord-006229-7yoilsho	3067	7	B	B	NNP
cord-006229-7yoilsho	3067	8	and	and	CC
cord-006229-7yoilsho	3067	9	C	C	NNP
cord-006229-7yoilsho	3067	10	leading	lead	VBG
cord-006229-7yoilsho	3067	11	to	to	IN
cord-006229-7yoilsho	3067	12	reorganization	reorganization	NN
cord-006229-7yoilsho	3067	13	of	of	IN
cord-006229-7yoilsho	3067	14	the	the	DT
cord-006229-7yoilsho	3067	15	actin	actin	NN
cord-006229-7yoilsho	3067	16	cytoskeleton	cytoskeleton	NN
cord-006229-7yoilsho	3067	17	and	and	CC
cord-006229-7yoilsho	3067	18	morphological	morphological	JJ
cord-006229-7yoilsho	3067	19	changes	change	NNS
cord-006229-7yoilsho	3067	20	.	.	.
cord-006229-7yoilsho	3068	1	In	in	IN
cord-006229-7yoilsho	3068	2	addition	addition	NN
cord-006229-7yoilsho	3068	3	to	to	IN
cord-006229-7yoilsho	3068	4	the	the	DT
cord-006229-7yoilsho	3068	5	enzyme	enzyme	NN
cord-006229-7yoilsho	3068	6	-	-	HYPH
cord-006229-7yoilsho	3068	7	based	base	VBN
cord-006229-7yoilsho	3068	8	inhibition	inhibition	NN
cord-006229-7yoilsho	3068	9	of	of	IN
cord-006229-7yoilsho	3068	10	Rho	rho	NN
cord-006229-7yoilsho	3068	11	-	-	HYPH
cord-006229-7yoilsho	3068	12	GTPases	gtpase	NNS
cord-006229-7yoilsho	3068	13	,	,	,
cord-006229-7yoilsho	3068	14	C3	C3	NNP
cord-006229-7yoilsho	3068	15	promotes	promote	VBZ
cord-006229-7yoilsho	3068	16	in	in	IN
cord-006229-7yoilsho	3068	17	an	an	DT
cord-006229-7yoilsho	3068	18	enzymeindependent	enzymeindependent	NN
cord-006229-7yoilsho	3068	19	manner	manner	NN
cord-006229-7yoilsho	3068	20	axonal	axonal	JJ
cord-006229-7yoilsho	3068	21	and	and	CC
cord-006229-7yoilsho	3068	22	dendritic	dendritic	JJ
cord-006229-7yoilsho	3068	23	growth	growth	NN
cord-006229-7yoilsho	3068	24	in	in	IN
cord-006229-7yoilsho	3068	25	neurons	neuron	NNS
cord-006229-7yoilsho	3068	26	.	.	.
cord-006229-7yoilsho	3069	1	As	as	IN
cord-006229-7yoilsho	3069	2	C3	C3	NNP
cord-006229-7yoilsho	3069	3	lacks	lack	VBZ
cord-006229-7yoilsho	3069	4	the	the	DT
cord-006229-7yoilsho	3069	5	canonical	canonical	JJ
cord-006229-7yoilsho	3069	6	binding	binding	NN
cord-006229-7yoilsho	3069	7	and	and	CC
cord-006229-7yoilsho	3069	8	translocation	translocation	NN
cord-006229-7yoilsho	3069	9	domains	domain	NNS
cord-006229-7yoilsho	3069	10	of	of	IN
cord-006229-7yoilsho	3069	11	bacterial	bacterial	JJ
cord-006229-7yoilsho	3069	12	protein	protein	NN
cord-006229-7yoilsho	3069	13	toxins	toxin	NNS
cord-006229-7yoilsho	3069	14	,	,	,
cord-006229-7yoilsho	3069	15	cell	cell	NN
cord-006229-7yoilsho	3069	16	entry	entry	NN
cord-006229-7yoilsho	3069	17	is	be	VBZ
cord-006229-7yoilsho	3069	18	currently	currently	RB
cord-006229-7yoilsho	3069	19	not	not	RB
cord-006229-7yoilsho	3069	20	well	well	RB
cord-006229-7yoilsho	3069	21	understood	understand	VBN
cord-006229-7yoilsho	3069	22	.	.	.
cord-006229-7yoilsho	3070	1	Based	base	VBN
cord-006229-7yoilsho	3070	2	on	on	IN
cord-006229-7yoilsho	3070	3	overlay	overlay	NN
cord-006229-7yoilsho	3070	4	assays	assay	NNS
cord-006229-7yoilsho	3070	5	and	and	CC
cord-006229-7yoilsho	3070	6	mass	mass	NN
cord-006229-7yoilsho	3070	7	spec	spec	NN
cord-006229-7yoilsho	3070	8	analyses	analyse	VBZ
cord-006229-7yoilsho	3070	9	the	the	DT
cord-006229-7yoilsho	3070	10	intermediate	intermediate	JJ
cord-006229-7yoilsho	3070	11	filament	filament	NN
cord-006229-7yoilsho	3070	12	vimentin	vimentin	NNP
cord-006229-7yoilsho	3070	13	was	be	VBD
cord-006229-7yoilsho	3070	14	identified	identify	VBN
cord-006229-7yoilsho	3070	15	as	as	IN
cord-006229-7yoilsho	3070	16	the	the	DT
cord-006229-7yoilsho	3070	17	putative	putative	JJ
cord-006229-7yoilsho	3070	18	membrane	membrane	NN
cord-006229-7yoilsho	3070	19	receptor	receptor	NN
cord-006229-7yoilsho	3070	20	for	for	IN
cord-006229-7yoilsho	3070	21	C3	C3	NNP
cord-006229-7yoilsho	3070	22	.	.	.
cord-006229-7yoilsho	3071	1	Knock	knock	VB
cord-006229-7yoilsho	3071	2	down	down	RP
cord-006229-7yoilsho	3071	3	of	of	IN
cord-006229-7yoilsho	3071	4	vimentin	vimentin	NN
cord-006229-7yoilsho	3071	5	by	by	IN
cord-006229-7yoilsho	3071	6	siRNA	siRNA	NNP
cord-006229-7yoilsho	3071	7	and	and	CC
cord-006229-7yoilsho	3071	8	application	application	NN
cord-006229-7yoilsho	3071	9	of	of	IN
cord-006229-7yoilsho	3071	10	the	the	DT
cord-006229-7yoilsho	3071	11	selective	selective	JJ
cord-006229-7yoilsho	3071	12	vimentin	vimentin	NN
cord-006229-7yoilsho	3071	13	disruptor	disruptor	NN
cord-006229-7yoilsho	3071	14	acrylamide	acrylamide	NN
cord-006229-7yoilsho	3071	15	led	lead	VBD
cord-006229-7yoilsho	3071	16	to	to	IN
cord-006229-7yoilsho	3071	17	a	a	DT
cord-006229-7yoilsho	3071	18	significantly	significantly	RB
cord-006229-7yoilsho	3071	19	delayed	delay	VBN
cord-006229-7yoilsho	3071	20	uptake	uptake	NN
cord-006229-7yoilsho	3071	21	of	of	IN
cord-006229-7yoilsho	3071	22	C3	C3	NNP
cord-006229-7yoilsho	3071	23	.	.	.
cord-006229-7yoilsho	3072	1	Moreover	moreover	RB
cord-006229-7yoilsho	3072	2	,	,	,
cord-006229-7yoilsho	3072	3	addition	addition	NN
cord-006229-7yoilsho	3072	4	of	of	IN
cord-006229-7yoilsho	3072	5	extracellular	extracellular	JJ
cord-006229-7yoilsho	3072	6	vimentin	vimentin	NNS
cord-006229-7yoilsho	3072	7	to	to	IN
cord-006229-7yoilsho	3072	8	cells	cell	NNS
cord-006229-7yoilsho	3072	9	induced	induce	VBN
cord-006229-7yoilsho	3072	10	an	an	DT
cord-006229-7yoilsho	3072	11	enhanced	enhanced	JJ
cord-006229-7yoilsho	3072	12	uptake	uptake	NN
cord-006229-7yoilsho	3072	13	of	of	IN
cord-006229-7yoilsho	3072	14	C3	C3	NNP
cord-006229-7yoilsho	3072	15	.	.	.
cord-006229-7yoilsho	3073	1	Proof	proof	NN
cord-006229-7yoilsho	3073	2	of	of	IN
cord-006229-7yoilsho	3073	3	principle	principle	JJ
cord-006229-7yoilsho	3073	4	experiments	experiment	NNS
cord-006229-7yoilsho	3073	5	in	in	IN
cord-006229-7yoilsho	3073	6	astrocytes	astrocyte	NNS
cord-006229-7yoilsho	3073	7	and	and	CC
cord-006229-7yoilsho	3073	8	neurons	neuron	NNS
cord-006229-7yoilsho	3073	9	from	from	IN
cord-006229-7yoilsho	3073	10	vimentin	vimentin	NNS
cord-006229-7yoilsho	3073	11	knock	knock	VB
cord-006229-7yoilsho	3073	12	out	out	RP
cord-006229-7yoilsho	3073	13	mice	mouse	NNS
cord-006229-7yoilsho	3073	14	showed	show	VBD
cord-006229-7yoilsho	3073	15	C3-induced	c3-induce	VBN
cord-006229-7yoilsho	3073	16	morphological	morphological	JJ
cord-006229-7yoilsho	3073	17	changes	change	NNS
cord-006229-7yoilsho	3073	18	(	(	-LRB-
cord-006229-7yoilsho	3073	19	astrocyte	astrocyte	NNP
cord-006229-7yoilsho	3073	20	stellation	stellation	NN
cord-006229-7yoilsho	3073	21	and	and	CC
cord-006229-7yoilsho	3073	22	axon	axon	NN
cord-006229-7yoilsho	3073	23	growth	growth	NN
cord-006229-7yoilsho	3073	24	)	)	-RRB-
cord-006229-7yoilsho	3073	25	to	to	IN
cord-006229-7yoilsho	3073	26	a	a	DT
cord-006229-7yoilsho	3073	27	reduced	reduce	VBN
cord-006229-7yoilsho	3073	28	extent	extent	NN
cord-006229-7yoilsho	3073	29	and	and	CC
cord-006229-7yoilsho	3073	30	a	a	DT
cord-006229-7yoilsho	3073	31	significantly	significantly	RB
cord-006229-7yoilsho	3073	32	delayed	delay	VBN
cord-006229-7yoilsho	3073	33	uptake	uptake	NN
cord-006229-7yoilsho	3073	34	of	of	IN
cord-006229-7yoilsho	3073	35	C3	c3	NN
cord-006229-7yoilsho	3073	36	compared	compare	VBN
cord-006229-7yoilsho	3073	37	to	to	IN
cord-006229-7yoilsho	3073	38	wild	wild	JJ
cord-006229-7yoilsho	3073	39	type	type	NN
cord-006229-7yoilsho	3073	40	cells	cell	NNS
cord-006229-7yoilsho	3073	41	.	.	.
cord-006229-7yoilsho	3074	1	As	as	IN
cord-006229-7yoilsho	3074	2	vimentin	vimentin	NNS
cord-006229-7yoilsho	3074	3	knock	knock	VB
cord-006229-7yoilsho	3074	4	out	out	RP
cord-006229-7yoilsho	3074	5	did	do	VBD
cord-006229-7yoilsho	3074	6	not	not	RB
cord-006229-7yoilsho	3074	7	completely	completely	RB
cord-006229-7yoilsho	3074	8	inhibit	inhibit	VB
cord-006229-7yoilsho	3074	9	C3	c3	NN
cord-006229-7yoilsho	3074	10	uptake	uptake	NN
cord-006229-7yoilsho	3074	11	into	into	IN
cord-006229-7yoilsho	3074	12	cells	cell	NNS
cord-006229-7yoilsho	3074	13	,	,	,
cord-006229-7yoilsho	3074	14	an	an	DT
cord-006229-7yoilsho	3074	15	additional	additional	JJ
cord-006229-7yoilsho	3074	16	uptake	uptake	NN
cord-006229-7yoilsho	3074	17	mechanism	mechanism	NN
cord-006229-7yoilsho	3074	18	or	or	CC
cord-006229-7yoilsho	3074	19	additional	additional	JJ
cord-006229-7yoilsho	3074	20	receptor	receptor	NN
cord-006229-7yoilsho	3074	21	for	for	IN
cord-006229-7yoilsho	3074	22	C3	C3	NNP
cord-006229-7yoilsho	3074	23	is	be	VBZ
cord-006229-7yoilsho	3074	24	likely	likely	JJ
cord-006229-7yoilsho	3074	25	.	.	.
cord-006229-7yoilsho	3075	1	Nevertheless	nevertheless	RB
cord-006229-7yoilsho	3075	2	,	,	,
cord-006229-7yoilsho	3075	3	our	-PRON-	PRP$
cord-006229-7yoilsho	3075	4	data	data	NN
cord-006229-7yoilsho	3075	5	reveals	reveal	VBZ
cord-006229-7yoilsho	3075	6	that	that	IN
cord-006229-7yoilsho	3075	7	C3	C3	NNP
cord-006229-7yoilsho	3075	8	employs	employ	VBZ
cord-006229-7yoilsho	3075	9	a	a	DT
cord-006229-7yoilsho	3075	10	specific	specific	JJ
cord-006229-7yoilsho	3075	11	endocytosis	endocytosis	NN
cord-006229-7yoilsho	3075	12	mechanism	mechanism	NN
cord-006229-7yoilsho	3075	13	with	with	IN
cord-006229-7yoilsho	3075	14	involvement	involvement	NN
cord-006229-7yoilsho	3075	15	of	of	IN
cord-006229-7yoilsho	3075	16	the	the	DT
cord-006229-7yoilsho	3075	17	intermediate	intermediate	JJ
cord-006229-7yoilsho	3075	18	filament	filament	NN
cord-006229-7yoilsho	3075	19	vimentin	vimentin	NN
cord-006229-7yoilsho	3075	20	to	to	TO
cord-006229-7yoilsho	3075	21	gain	gain	VB
cord-006229-7yoilsho	3075	22	access	access	NN
cord-006229-7yoilsho	3075	23	to	to	IN
cord-006229-7yoilsho	3075	24	host	host	NN
cord-006229-7yoilsho	3075	25	cells	cell	NNS
cord-006229-7yoilsho	3075	26	.	.	.
cord-006229-7yoilsho	3076	1	The	the	DT
cord-006229-7yoilsho	3076	2	primary	primary	JJ
cord-006229-7yoilsho	3076	3	target	target	NN
cord-006229-7yoilsho	3076	4	organ	organ	NN
cord-006229-7yoilsho	3076	5	of	of	IN
cord-006229-7yoilsho	3076	6	organic	organic	JJ
cord-006229-7yoilsho	3076	7	Hg	Hg	NNP
cord-006229-7yoilsho	3076	8	species	species	NN
cord-006229-7yoilsho	3076	9	-	-	HYPH
cord-006229-7yoilsho	3076	10	mediated	mediate	VBN
cord-006229-7yoilsho	3076	11	toxicity	toxicity	NN
cord-006229-7yoilsho	3076	12	is	be	VBZ
cord-006229-7yoilsho	3076	13	the	the	DT
cord-006229-7yoilsho	3076	14	central	central	JJ
cord-006229-7yoilsho	3076	15	nervous	nervous	JJ
cord-006229-7yoilsho	3076	16	system	system	NN
cord-006229-7yoilsho	3076	17	(	(	-LRB-
cord-006229-7yoilsho	3076	18	CNS	CNS	NNP
cord-006229-7yoilsho	3076	19	)	)	-RRB-
cord-006229-7yoilsho	3076	20	.	.	.
cord-006229-7yoilsho	3077	1	Humans	human	NNS
cord-006229-7yoilsho	3077	2	are	be	VBP
cord-006229-7yoilsho	3077	3	exposed	expose	VBN
cord-006229-7yoilsho	3077	4	to	to	IN
cord-006229-7yoilsho	3077	5	organic	organic	JJ
cord-006229-7yoilsho	3077	6	Hg	Hg	NNP
cord-006229-7yoilsho	3077	7	mainly	mainly	RB
cord-006229-7yoilsho	3077	8	in	in	IN
cord-006229-7yoilsho	3077	9	the	the	DT
cord-006229-7yoilsho	3077	10	form	form	NN
cord-006229-7yoilsho	3077	11	of	of	IN
cord-006229-7yoilsho	3077	12	methylmercury	methylmercury	NN
cord-006229-7yoilsho	3077	13	(	(	-LRB-
cord-006229-7yoilsho	3077	14	MeHg	MeHg	NNP
cord-006229-7yoilsho	3077	15	)	)	-RRB-
cord-006229-7yoilsho	3077	16	via	via	IN
cord-006229-7yoilsho	3077	17	the	the	DT
cord-006229-7yoilsho	3077	18	consumption	consumption	NN
cord-006229-7yoilsho	3077	19	of	of	IN
cord-006229-7yoilsho	3077	20	contaminated	contaminated	JJ
cord-006229-7yoilsho	3077	21	fish	fish	NN
cord-006229-7yoilsho	3077	22	and	and	CC
cord-006229-7yoilsho	3077	23	other	other	JJ
cord-006229-7yoilsho	3077	24	seafood	seafood	NN
cord-006229-7yoilsho	3077	25	products	product	NNS
cord-006229-7yoilsho	3077	26	.	.	.
cord-006229-7yoilsho	3078	1	In	in	IN
cord-006229-7yoilsho	3078	2	terrestrial	terrestrial	JJ
cord-006229-7yoilsho	3078	3	food	food	NN
cord-006229-7yoilsho	3078	4	sources	source	NNS
cord-006229-7yoilsho	3078	5	Hg	Hg	NNP
cord-006229-7yoilsho	3078	6	is	be	VBZ
cord-006229-7yoilsho	3078	7	mostly	mostly	RB
cord-006229-7yoilsho	3078	8	found	find	VBN
cord-006229-7yoilsho	3078	9	as	as	IN
cord-006229-7yoilsho	3078	10	inorganic	inorganic	JJ
cord-006229-7yoilsho	3078	11	Hg	Hg	NNP
cord-006229-7yoilsho	3078	12	.	.	.
cord-006229-7yoilsho	3079	1	Thiomersal	Thiomersal	NNP
cord-006229-7yoilsho	3079	2	is	be	VBZ
cord-006229-7yoilsho	3079	3	a	a	DT
cord-006229-7yoilsho	3079	4	further	further	JJ
cord-006229-7yoilsho	3079	5	organic	organic	JJ
cord-006229-7yoilsho	3079	6	Hg	Hg	NNP
cord-006229-7yoilsho	3079	7	compound	compound	NN
cord-006229-7yoilsho	3079	8	which	which	WDT
cord-006229-7yoilsho	3079	9	is	be	VBZ
cord-006229-7yoilsho	3079	10	used	use	VBN
cord-006229-7yoilsho	3079	11	as	as	IN
cord-006229-7yoilsho	3079	12	a	a	DT
cord-006229-7yoilsho	3079	13	preservative	preservative	NN
cord-006229-7yoilsho	3079	14	in	in	IN
cord-006229-7yoilsho	3079	15	medical	medical	JJ
cord-006229-7yoilsho	3079	16	preparations	preparation	NNS
cord-006229-7yoilsho	3079	17	.	.	.
cord-006229-7yoilsho	3080	1	Exposure	exposure	NN
cord-006229-7yoilsho	3080	2	to	to	IN
cord-006229-7yoilsho	3080	3	organic	organic	JJ
cord-006229-7yoilsho	3080	4	Hg	Hg	NNP
cord-006229-7yoilsho	3080	5	promotes	promote	VBZ
cord-006229-7yoilsho	3080	6	primarily	primarily	RB
cord-006229-7yoilsho	3080	7	neurological	neurological	JJ
cord-006229-7yoilsho	3080	8	effects	effect	NNS
cord-006229-7yoilsho	3080	9	.	.	.
cord-006229-7yoilsho	3081	1	The	the	DT
cord-006229-7yoilsho	3081	2	understanding	understanding	NN
cord-006229-7yoilsho	3081	3	of	of	IN
cord-006229-7yoilsho	3081	4	transfer	transfer	NN
cord-006229-7yoilsho	3081	5	mechanisms	mechanism	NNS
cord-006229-7yoilsho	3081	6	regarding	regard	VBG
cord-006229-7yoilsho	3081	7	the	the	DT
cord-006229-7yoilsho	3081	8	CNS	CNS	NNP
cord-006229-7yoilsho	3081	9	is	be	VBZ
cord-006229-7yoilsho	3081	10	an	an	DT
cord-006229-7yoilsho	3081	11	important	important	JJ
cord-006229-7yoilsho	3081	12	precondition	precondition	NN
cord-006229-7yoilsho	3081	13	for	for	IN
cord-006229-7yoilsho	3081	14	an	an	DT
cord-006229-7yoilsho	3081	15	evaluation	evaluation	NN
cord-006229-7yoilsho	3081	16	of	of	IN
cord-006229-7yoilsho	3081	17	Hg	Hg	NNP
cord-006229-7yoilsho	3081	18	species	species	NN
cord-006229-7yoilsho	3081	19	-	-	HYPH
cord-006229-7yoilsho	3081	20	induced	induce	VBN
cord-006229-7yoilsho	3081	21	neurotoxicity	neurotoxicity	NN
cord-006229-7yoilsho	3081	22	.	.	.
cord-006229-7yoilsho	3082	1	Thus	thus	RB
cord-006229-7yoilsho	3082	2	,	,	,
cord-006229-7yoilsho	3082	3	primary	primary	JJ
cord-006229-7yoilsho	3082	4	porcine	porcine	NN
cord-006229-7yoilsho	3082	5	in	in	IN
cord-006229-7yoilsho	3082	6	vitro	vitro	FW
cord-006229-7yoilsho	3082	7	models	model	NNS
cord-006229-7yoilsho	3082	8	of	of	IN
cord-006229-7yoilsho	3082	9	the	the	DT
cord-006229-7yoilsho	3082	10	bloodbrain	bloodbrain	NN
cord-006229-7yoilsho	3082	11	barrier	barrier	NN
cord-006229-7yoilsho	3082	12	and	and	CC
cord-006229-7yoilsho	3082	13	the	the	DT
cord-006229-7yoilsho	3082	14	blood	blood	NN
cord-006229-7yoilsho	3082	15	-	-	HYPH
cord-006229-7yoilsho	3082	16	cerebrospinal	cerebrospinal	NN
cord-006229-7yoilsho	3082	17	fluid	fluid	NN
cord-006229-7yoilsho	3082	18	(	(	-LRB-
cord-006229-7yoilsho	3082	19	CSF	CSF	NNP
cord-006229-7yoilsho	3082	20	)	)	-RRB-
cord-006229-7yoilsho	3082	21	barrier	barrier	NN
cord-006229-7yoilsho	3082	22	were	be	VBD
cord-006229-7yoilsho	3082	23	used	use	VBN
cord-006229-7yoilsho	3082	24	to	to	TO
cord-006229-7yoilsho	3082	25	investigate	investigate	VB
cord-006229-7yoilsho	3082	26	effects	effect	NNS
cord-006229-7yoilsho	3082	27	of	of	IN
cord-006229-7yoilsho	3082	28	MeHgCl	mehgcl	NN
cord-006229-7yoilsho	3082	29	,	,	,
cord-006229-7yoilsho	3082	30	thiomersal	thiomersal	NN
cord-006229-7yoilsho	3082	31	and	and	CC
cord-006229-7yoilsho	3082	32	HgCl	HgCl	NNP
cord-006229-7yoilsho	3082	33	2	2	CD
cord-006229-7yoilsho	3082	34	on	on	IN
cord-006229-7yoilsho	3082	35	the	the	DT
cord-006229-7yoilsho	3082	36	barriers	barrier	NNS
cord-006229-7yoilsho	3082	37	as	as	RB
cord-006229-7yoilsho	3082	38	well	well	RB
cord-006229-7yoilsho	3082	39	as	as	IN
cord-006229-7yoilsho	3082	40	transfer	transfer	NN
cord-006229-7yoilsho	3082	41	properties	property	NNS
cord-006229-7yoilsho	3082	42	into	into	IN
cord-006229-7yoilsho	3082	43	and	and	CC
cord-006229-7yoilsho	3082	44	out	out	IN
cord-006229-7yoilsho	3082	45	of	of	IN
cord-006229-7yoilsho	3082	46	the	the	DT
cord-006229-7yoilsho	3082	47	CNS	CNS	NNP
cord-006229-7yoilsho	3082	48	in	in	IN
cord-006229-7yoilsho	3082	49	vitro	vitro	FW
cord-006229-7yoilsho	3082	50	.	.	.
cord-006229-7yoilsho	3083	1	The	the	DT
cord-006229-7yoilsho	3083	2	results	result	NNS
cord-006229-7yoilsho	3083	3	show	show	VBP
cord-006229-7yoilsho	3083	4	significant	significant	JJ
cord-006229-7yoilsho	3083	5	transfer	transfer	NN
cord-006229-7yoilsho	3083	6	differences	difference	NNS
cord-006229-7yoilsho	3083	7	of	of	IN
cord-006229-7yoilsho	3083	8	the	the	DT
cord-006229-7yoilsho	3083	9	various	various	JJ
cord-006229-7yoilsho	3083	10	incubated	incubate	VBN
cord-006229-7yoilsho	3083	11	species	specie	NNS
cord-006229-7yoilsho	3083	12	as	as	RB
cord-006229-7yoilsho	3083	13	well	well	RB
cord-006229-7yoilsho	3083	14	as	as	IN
cord-006229-7yoilsho	3083	15	in	in	IN
cord-006229-7yoilsho	3083	16	the	the	DT
cord-006229-7yoilsho	3083	17	different	different	JJ
cord-006229-7yoilsho	3083	18	barrier	barrier	NN
cord-006229-7yoilsho	3083	19	systems	system	NNS
cord-006229-7yoilsho	3083	20	.	.	.
cord-006229-7yoilsho	3084	1	Whereas	whereas	IN
cord-006229-7yoilsho	3084	2	the	the	DT
cord-006229-7yoilsho	3084	3	bloodbrain	bloodbrain	NN
cord-006229-7yoilsho	3084	4	barrier	barrier	NN
cord-006229-7yoilsho	3084	5	seems	seem	VBZ
cord-006229-7yoilsho	3084	6	to	to	TO
cord-006229-7yoilsho	3084	7	account	account	VB
cord-006229-7yoilsho	3084	8	for	for	IN
cord-006229-7yoilsho	3084	9	the	the	DT
cord-006229-7yoilsho	3084	10	transfer	transfer	NN
cord-006229-7yoilsho	3084	11	of	of	IN
cord-006229-7yoilsho	3084	12	organic	organic	JJ
cord-006229-7yoilsho	3084	13	Hg	Hg	NNP
cord-006229-7yoilsho	3084	14	species	specie	NNS
cord-006229-7yoilsho	3084	15	from	from	IN
cord-006229-7yoilsho	3084	16	the	the	DT
cord-006229-7yoilsho	3084	17	blood	blood	NN
cord-006229-7yoilsho	3084	18	side	side	NN
cord-006229-7yoilsho	3084	19	to	to	IN
cord-006229-7yoilsho	3084	20	the	the	DT
cord-006229-7yoilsho	3084	21	brain	brain	NN
cord-006229-7yoilsho	3084	22	side	side	NN
cord-006229-7yoilsho	3084	23	,	,	,
cord-006229-7yoilsho	3084	24	these	these	DT
cord-006229-7yoilsho	3084	25	species	specie	NNS
cord-006229-7yoilsho	3084	26	are	be	VBP
cord-006229-7yoilsho	3084	27	transferred	transfer	VBN
cord-006229-7yoilsho	3084	28	in	in	IN
cord-006229-7yoilsho	3084	29	the	the	DT
cord-006229-7yoilsho	3084	30	contrary	contrary	JJ
cord-006229-7yoilsho	3084	31	direction	direction	NN
cord-006229-7yoilsho	3084	32	by	by	IN
cord-006229-7yoilsho	3084	33	the	the	DT
cord-006229-7yoilsho	3084	34	blood	blood	NN
cord-006229-7yoilsho	3084	35	-	-	HYPH
cord-006229-7yoilsho	3084	36	CSF	csf	NN
cord-006229-7yoilsho	3084	37	barrier	barrier	NN
cord-006229-7yoilsho	3084	38	.	.	.
cord-006229-7yoilsho	3085	1	Inorganic	inorganic	JJ
cord-006229-7yoilsho	3085	2	HgCl	HgCl	NNP
cord-006229-7yoilsho	3085	3	2	2	CD
cord-006229-7yoilsho	3085	4	was	be	VBD
cord-006229-7yoilsho	3085	5	not	not	RB
cord-006229-7yoilsho	3085	6	transferred	transfer	VBN
cord-006229-7yoilsho	3085	7	across	across	IN
cord-006229-7yoilsho	3085	8	both	both	DT
cord-006229-7yoilsho	3085	9	brain	brain	NN
cord-006229-7yoilsho	3085	10	barriers	barrier	NNS
cord-006229-7yoilsho	3085	11	towards	towards	IN
cord-006229-7yoilsho	3085	12	the	the	DT
cord-006229-7yoilsho	3085	13	brain	brain	NN
cord-006229-7yoilsho	3085	14	side	side	NN
cord-006229-7yoilsho	3085	15	but	but	CC
cord-006229-7yoilsho	3085	16	was	be	VBD
cord-006229-7yoilsho	3085	17	able	able	JJ
cord-006229-7yoilsho	3085	18	to	to	TO
cord-006229-7yoilsho	3085	19	leave	leave	VB
cord-006229-7yoilsho	3085	20	the	the	DT
cord-006229-7yoilsho	3085	21	brain	brain	NN
cord-006229-7yoilsho	3085	22	side	side	NN
cord-006229-7yoilsho	3085	23	across	across	IN
cord-006229-7yoilsho	3085	24	the	the	DT
cord-006229-7yoilsho	3085	25	blood	blood	NN
cord-006229-7yoilsho	3085	26	-	-	HYPH
cord-006229-7yoilsho	3085	27	brain	brain	NN
cord-006229-7yoilsho	3085	28	barrier	barrier	NN
cord-006229-7yoilsho	3085	29	.	.	.
cord-006229-7yoilsho	3086	1	Additionally	additionally	RB
cord-006229-7yoilsho	3086	2	,	,	,
cord-006229-7yoilsho	3086	3	cytotoxic	cytotoxic	JJ
cord-006229-7yoilsho	3086	4	effects	effect	NNS
cord-006229-7yoilsho	3086	5	of	of	IN
cord-006229-7yoilsho	3086	6	the	the	DT
cord-006229-7yoilsho	3086	7	Hg	Hg	NNP
cord-006229-7yoilsho	3086	8	species	specie	NNS
cord-006229-7yoilsho	3086	9	by	by	IN
cord-006229-7yoilsho	3086	10	themselves	-PRON-	PRP
cord-006229-7yoilsho	3086	11	as	as	RB
cord-006229-7yoilsho	3086	12	well	well	RB
cord-006229-7yoilsho	3086	13	as	as	IN
cord-006229-7yoilsho	3086	14	the	the	DT
cord-006229-7yoilsho	3086	15	combination	combination	NN
cord-006229-7yoilsho	3086	16	of	of	IN
cord-006229-7yoilsho	3086	17	organic	organic	JJ
cord-006229-7yoilsho	3086	18	and	and	CC
cord-006229-7yoilsho	3086	19	inorganic	inorganic	JJ
cord-006229-7yoilsho	3086	20	Hg	Hg	NNP
cord-006229-7yoilsho	3086	21	species	specie	NNS
cord-006229-7yoilsho	3086	22	have	have	VBP
cord-006229-7yoilsho	3086	23	been	be	VBN
cord-006229-7yoilsho	3086	24	investigated	investigate	VBN
cord-006229-7yoilsho	3086	25	in	in	IN
cord-006229-7yoilsho	3086	26	human	human	JJ
cord-006229-7yoilsho	3086	27	astrocytes	astrocyte	NNS
cord-006229-7yoilsho	3086	28	and	and	CC
cord-006229-7yoilsho	3086	29	human	human	JJ
cord-006229-7yoilsho	3086	30	differentiated	differentiated	JJ
cord-006229-7yoilsho	3086	31	neurons	neuron	NNS
cord-006229-7yoilsho	3086	32	.	.	.
cord-006229-7yoilsho	3087	1	Differentiated	differentiated	JJ
cord-006229-7yoilsho	3087	2	neurons	neuron	NNS
cord-006229-7yoilsho	3087	3	were	be	VBD
cord-006229-7yoilsho	3087	4	much	much	RB
cord-006229-7yoilsho	3087	5	more	more	RBR
cord-006229-7yoilsho	3087	6	sensitive	sensitive	JJ
cord-006229-7yoilsho	3087	7	towards	towards	IN
cord-006229-7yoilsho	3087	8	all	all	DT
cord-006229-7yoilsho	3087	9	Hg	Hg	NNP
cord-006229-7yoilsho	3087	10	species	specie	NNS
cord-006229-7yoilsho	3087	11	.	.	.
cord-006229-7yoilsho	3088	1	Organic	organic	JJ
cord-006229-7yoilsho	3088	2	species	specie	NNS
cord-006229-7yoilsho	3088	3	exerted	exert	VBD
cord-006229-7yoilsho	3088	4	stronger	strong	JJR
cord-006229-7yoilsho	3088	5	cytotoxic	cytotoxic	JJ
cord-006229-7yoilsho	3088	6	effects	effect	NNS
cord-006229-7yoilsho	3088	7	in	in	IN
cord-006229-7yoilsho	3088	8	both	both	DT
cord-006229-7yoilsho	3088	9	cell	cell	NN
cord-006229-7yoilsho	3088	10	types	type	NNS
cord-006229-7yoilsho	3088	11	as	as	IN
cord-006229-7yoilsho	3088	12	compared	compare	VBN
cord-006229-7yoilsho	3088	13	to	to	IN
cord-006229-7yoilsho	3088	14	HgCl	HgCl	NNP
cord-006229-7yoilsho	3088	15	2	2	CD
cord-006229-7yoilsho	3088	16	.	.	.
cord-006229-7yoilsho	3089	1	Interestingly	interestingly	RB
cord-006229-7yoilsho	3089	2	,	,	,
cord-006229-7yoilsho	3089	3	a	a	DT
cord-006229-7yoilsho	3089	4	coincubation	coincubation	NN
cord-006229-7yoilsho	3089	5	of	of	IN
cord-006229-7yoilsho	3089	6	organic	organic	JJ
cord-006229-7yoilsho	3089	7	and	and	CC
cord-006229-7yoilsho	3089	8	inorganic	inorganic	JJ
cord-006229-7yoilsho	3089	9	Hg	Hg	NNP
cord-006229-7yoilsho	3089	10	species	specie	NNS
cord-006229-7yoilsho	3089	11	led	lead	VBD
cord-006229-7yoilsho	3089	12	to	to	IN
cord-006229-7yoilsho	3089	13	an	an	DT
cord-006229-7yoilsho	3089	14	increased	increase	VBN
cord-006229-7yoilsho	3089	15	cytotoxicity	cytotoxicity	NN
cord-006229-7yoilsho	3089	16	in	in	IN
cord-006229-7yoilsho	3089	17	the	the	DT
cord-006229-7yoilsho	3089	18	astrocytes	astrocyte	NNS
cord-006229-7yoilsho	3089	19	.	.	.
cord-006229-7yoilsho	3090	1	This	this	DT
cord-006229-7yoilsho	3090	2	cocytotoxic	cocytotoxic	JJ
cord-006229-7yoilsho	3090	3	effect	effect	NN
cord-006229-7yoilsho	3090	4	is	be	VBZ
cord-006229-7yoilsho	3090	5	currently	currently	RB
cord-006229-7yoilsho	3090	6	investigated	investigate	VBN
cord-006229-7yoilsho	3090	7	in	in	IN
cord-006229-7yoilsho	3090	8	differentiated	differentiated	JJ
cord-006229-7yoilsho	3090	9	neurons	neuron	NNS
cord-006229-7yoilsho	3090	10	.	.	.
cord-006229-7yoilsho	3091	1	The	the	DT
cord-006229-7yoilsho	3091	2	species	species	NN
cord-006229-7yoilsho	3091	3	-	-	HYPH
cord-006229-7yoilsho	3091	4	specific	specific	JJ
cord-006229-7yoilsho	3091	5	differences	difference	NNS
cord-006229-7yoilsho	3091	6	with	with	IN
cord-006229-7yoilsho	3091	7	respect	respect	NN
cord-006229-7yoilsho	3091	8	to	to	IN
cord-006229-7yoilsho	3091	9	both	both	DT
cord-006229-7yoilsho	3091	10	,	,	,
cord-006229-7yoilsho	3091	11	effects	effect	NNS
cord-006229-7yoilsho	3091	12	on	on	IN
cord-006229-7yoilsho	3091	13	and	and	CC
cord-006229-7yoilsho	3091	14	transfer	transfer	VB
cord-006229-7yoilsho	3091	15	across	across	IN
cord-006229-7yoilsho	3091	16	the	the	DT
cord-006229-7yoilsho	3091	17	blood	blood	NN
cord-006229-7yoilsho	3091	18	-	-	HYPH
cord-006229-7yoilsho	3091	19	brain	brain	NN
cord-006229-7yoilsho	3091	20	and	and	CC
cord-006229-7yoilsho	3091	21	the	the	DT
cord-006229-7yoilsho	3091	22	blood	blood	NN
cord-006229-7yoilsho	3091	23	-	-	HYPH
cord-006229-7yoilsho	3091	24	CSF	csf	NN
cord-006229-7yoilsho	3091	25	barrier	barrier	NN
cord-006229-7yoilsho	3091	26	in	in	IN
cord-006229-7yoilsho	3091	27	vitro	vitro	FW
cord-006229-7yoilsho	3091	28	as	as	RB
cord-006229-7yoilsho	3091	29	well	well	RB
cord-006229-7yoilsho	3091	30	as	as	IN
cord-006229-7yoilsho	3091	31	toxic	toxic	JJ
cord-006229-7yoilsho	3091	32	effects	effect	NNS
cord-006229-7yoilsho	3091	33	in	in	IN
cord-006229-7yoilsho	3091	34	brain	brain	NN
cord-006229-7yoilsho	3091	35	target	target	NN
cord-006229-7yoilsho	3091	36	cells	cell	NNS
cord-006229-7yoilsho	3091	37	,	,	,
cord-006229-7yoilsho	3091	38	clearly	clearly	RB
cord-006229-7yoilsho	3091	39	emphasizes	emphasize	VBZ
cord-006229-7yoilsho	3091	40	the	the	DT
cord-006229-7yoilsho	3091	41	necessity	necessity	NN
cord-006229-7yoilsho	3091	42	for	for	IN
cord-006229-7yoilsho	3091	43	comparative	comparative	JJ
cord-006229-7yoilsho	3091	44	analyses	analysis	NNS
cord-006229-7yoilsho	3091	45	.	.	.
cord-006229-7yoilsho	3092	1	Introduction	introduction	NN
cord-006229-7yoilsho	3092	2	:	:	:
cord-006229-7yoilsho	3093	1	The	the	DT
cord-006229-7yoilsho	3093	2	neural	neural	JJ
cord-006229-7yoilsho	3093	3	crest	crest	NN
cord-006229-7yoilsho	3093	4	is	be	VBZ
cord-006229-7yoilsho	3093	5	a	a	DT
cord-006229-7yoilsho	3093	6	multipotent	multipotent	JJ
cord-006229-7yoilsho	3093	7	stem	stem	NN
cord-006229-7yoilsho	3093	8	cell	cell	NN
cord-006229-7yoilsho	3093	9	population	population	NN
cord-006229-7yoilsho	3093	10	that	that	WDT
cord-006229-7yoilsho	3093	11	arises	arise	VBZ
cord-006229-7yoilsho	3093	12	at	at	IN
cord-006229-7yoilsho	3093	13	the	the	DT
cord-006229-7yoilsho	3093	14	neural	neural	JJ
cord-006229-7yoilsho	3093	15	plate	plate	NN
cord-006229-7yoilsho	3093	16	border	border	NN
cord-006229-7yoilsho	3093	17	during	during	IN
cord-006229-7yoilsho	3093	18	early	early	JJ
cord-006229-7yoilsho	3093	19	fetal	fetal	JJ
cord-006229-7yoilsho	3093	20	development	development	NN
cord-006229-7yoilsho	3093	21	.	.	.
cord-006229-7yoilsho	3094	1	Neural	neural	JJ
cord-006229-7yoilsho	3094	2	crest	crest	NN
cord-006229-7yoilsho	3094	3	cells	cell	NNS
cord-006229-7yoilsho	3094	4	(	(	-LRB-
cord-006229-7yoilsho	3094	5	NCCs	ncc	NNS
cord-006229-7yoilsho	3094	6	)	)	-RRB-
cord-006229-7yoilsho	3094	7	migrate	migrate	VBP
cord-006229-7yoilsho	3094	8	to	to	TO
cord-006229-7yoilsho	3094	9	target	target	VB
cord-006229-7yoilsho	3094	10	sites	site	NNS
cord-006229-7yoilsho	3094	11	in	in	IN
cord-006229-7yoilsho	3094	12	the	the	DT
cord-006229-7yoilsho	3094	13	periphery	periphery	NN
cord-006229-7yoilsho	3094	14	,	,	,
cord-006229-7yoilsho	3094	15	where	where	WRB
cord-006229-7yoilsho	3094	16	they	-PRON-	PRP
cord-006229-7yoilsho	3094	17	differentiate	differentiate	VBP
cord-006229-7yoilsho	3094	18	into	into	IN
cord-006229-7yoilsho	3094	19	multiple	multiple	JJ
cord-006229-7yoilsho	3094	20	cell	cell	NN
cord-006229-7yoilsho	3094	21	types	type	NNS
cord-006229-7yoilsho	3094	22	,	,	,
cord-006229-7yoilsho	3094	23	including	include	VBG
cord-006229-7yoilsho	3094	24	melanocytes	melanocyte	NNS
cord-006229-7yoilsho	3094	25	,	,	,
cord-006229-7yoilsho	3094	26	cranial	cranial	JJ
cord-006229-7yoilsho	3094	27	bones	bone	NNS
cord-006229-7yoilsho	3094	28	and	and	CC
cord-006229-7yoilsho	3094	29	peripheral	peripheral	JJ
cord-006229-7yoilsho	3094	30	neurons	neuron	NNS
cord-006229-7yoilsho	3094	31	.	.	.
cord-006229-7yoilsho	3095	1	Failure	failure	NN
cord-006229-7yoilsho	3095	2	of	of	IN
cord-006229-7yoilsho	3095	3	NCC	NCC	NNP
cord-006229-7yoilsho	3095	4	migration	migration	NN
cord-006229-7yoilsho	3095	5	can	can	MD
cord-006229-7yoilsho	3095	6	lead	lead	VB
cord-006229-7yoilsho	3095	7	to	to	IN
cord-006229-7yoilsho	3095	8	severe	severe	JJ
cord-006229-7yoilsho	3095	9	disorders	disorder	NNS
cord-006229-7yoilsho	3095	10	,	,	,
cord-006229-7yoilsho	3095	11	such	such	JJ
cord-006229-7yoilsho	3095	12	as	as	IN
cord-006229-7yoilsho	3095	13	Hirschsprung	Hirschsprung	NNP
cord-006229-7yoilsho	3095	14	's	's	POS
cord-006229-7yoilsho	3095	15	disease	disease	NN
cord-006229-7yoilsho	3095	16	.	.	.
cord-006229-7yoilsho	3096	1	Aim	aim	VB
cord-006229-7yoilsho	3096	2	:	:	:
cord-006229-7yoilsho	3096	3	To	to	TO
cord-006229-7yoilsho	3096	4	test	test	VB
cord-006229-7yoilsho	3096	5	whether	whether	IN
cord-006229-7yoilsho	3096	6	toxicants	toxicant	NNS
cord-006229-7yoilsho	3096	7	interfere	interfere	VB
cord-006229-7yoilsho	3096	8	with	with	IN
cord-006229-7yoilsho	3096	9	human	human	JJ
cord-006229-7yoilsho	3096	10	NCC	NCC	NNP
cord-006229-7yoilsho	3096	11	migration	migration	NN
cord-006229-7yoilsho	3096	12	,	,	,
cord-006229-7yoilsho	3096	13	a	a	DT
cord-006229-7yoilsho	3096	14	high	high	JJ
cord-006229-7yoilsho	3096	15	-	-	HYPH
cord-006229-7yoilsho	3096	16	throughput	throughput	NN
cord-006229-7yoilsho	3096	17	migration	migration	NN
cord-006229-7yoilsho	3096	18	assay	assay	NN
cord-006229-7yoilsho	3096	19	was	be	VBD
cord-006229-7yoilsho	3096	20	established	establish	VBN
cord-006229-7yoilsho	3096	21	.	.	.
cord-006229-7yoilsho	3097	1	This	this	DT
cord-006229-7yoilsho	3097	2	test	test	NN
cord-006229-7yoilsho	3097	3	system	system	NN
cord-006229-7yoilsho	3097	4	was	be	VBD
cord-006229-7yoilsho	3097	5	used	use	VBN
cord-006229-7yoilsho	3097	6	to	to	TO
cord-006229-7yoilsho	3097	7	screen	screen	VB
cord-006229-7yoilsho	3097	8	an	an	DT
cord-006229-7yoilsho	3097	9	80	80	CD
cord-006229-7yoilsho	3097	10	compound	compound	NN
cord-006229-7yoilsho	3097	11	library	library	NN
cord-006229-7yoilsho	3097	12	of	of	IN
cord-006229-7yoilsho	3097	13	potential	potential	JJ
cord-006229-7yoilsho	3097	14	developmental	developmental	JJ
cord-006229-7yoilsho	3097	15	toxicants	toxicant	NNS
cord-006229-7yoilsho	3097	16	.	.	.
cord-006229-7yoilsho	3098	1	Methods	method	NNS
cord-006229-7yoilsho	3098	2	:	:	:
cord-006229-7yoilsho	3098	3	NCCs	ncc	NNS
cord-006229-7yoilsho	3098	4	were	be	VBD
cord-006229-7yoilsho	3098	5	derived	derive	VBN
cord-006229-7yoilsho	3098	6	from	from	IN
cord-006229-7yoilsho	3098	7	human	human	JJ
cord-006229-7yoilsho	3098	8	embryonic	embryonic	JJ
cord-006229-7yoilsho	3098	9	stem	stem	NN
cord-006229-7yoilsho	3098	10	cells	cell	NNS
cord-006229-7yoilsho	3098	11	.	.	.
cord-006229-7yoilsho	3099	1	The	the	DT
cord-006229-7yoilsho	3099	2	cells	cell	NNS
cord-006229-7yoilsho	3099	3	were	be	VBD
cord-006229-7yoilsho	3099	4	allowed	allow	VBN
cord-006229-7yoilsho	3099	5	to	to	TO
cord-006229-7yoilsho	3099	6	migrate	migrate	VB
cord-006229-7yoilsho	3099	7	for	for	IN
cord-006229-7yoilsho	3099	8	24	24	CD
cord-006229-7yoilsho	3099	9	h	h	NN
cord-006229-7yoilsho	3099	10	before	before	IN
cord-006229-7yoilsho	3099	11	toxicants	toxicant	NNS
cord-006229-7yoilsho	3099	12	were	be	VBD
cord-006229-7yoilsho	3099	13	added	add	VBN
cord-006229-7yoilsho	3099	14	to	to	IN
cord-006229-7yoilsho	3099	15	the	the	DT
cord-006229-7yoilsho	3099	16	cells	cell	NNS
cord-006229-7yoilsho	3099	17	.	.	.
cord-006229-7yoilsho	3100	1	Migration	migration	NN
cord-006229-7yoilsho	3100	2	and	and	CC
cord-006229-7yoilsho	3100	3	viability	viability	NN
cord-006229-7yoilsho	3100	4	of	of	IN
cord-006229-7yoilsho	3100	5	the	the	DT
cord-006229-7yoilsho	3100	6	cells	cell	NNS
cord-006229-7yoilsho	3100	7	were	be	VBD
cord-006229-7yoilsho	3100	8	then	then	RB
cord-006229-7yoilsho	3100	9	measured	measure	VBN
cord-006229-7yoilsho	3100	10	after	after	IN
cord-006229-7yoilsho	3100	11	another	another	DT
cord-006229-7yoilsho	3100	12	24	24	CD
cord-006229-7yoilsho	3100	13	h	h	NN
cord-006229-7yoilsho	3100	14	by	by	IN
cord-006229-7yoilsho	3100	15	high	high	JJ
cord-006229-7yoilsho	3100	16	-	-	HYPH
cord-006229-7yoilsho	3100	17	content	content	NN
cord-006229-7yoilsho	3100	18	image	image	NN
cord-006229-7yoilsho	3100	19	analysis	analysis	NN
cord-006229-7yoilsho	3100	20	and	and	CC
cord-006229-7yoilsho	3100	21	a	a	DT
cord-006229-7yoilsho	3100	22	custom	custom	NN
cord-006229-7yoilsho	3100	23	-	-	HYPH
cord-006229-7yoilsho	3100	24	developed	develop	VBN
cord-006229-7yoilsho	3100	25	software	software	NN
cord-006229-7yoilsho	3100	26	package	package	NN
cord-006229-7yoilsho	3100	27	.	.	.
cord-006229-7yoilsho	3101	1	Results	result	NNS
cord-006229-7yoilsho	3101	2	:	:	:
cord-006229-7yoilsho	3102	1	The	the	DT
cord-006229-7yoilsho	3102	2	screening	screening	NN
cord-006229-7yoilsho	3102	3	library	library	NN
cord-006229-7yoilsho	3102	4	was	be	VBD
cord-006229-7yoilsho	3102	5	assembled	assemble	VBN
cord-006229-7yoilsho	3102	6	by	by	IN
cord-006229-7yoilsho	3102	7	the	the	DT
cord-006229-7yoilsho	3102	8	US	US	NNP
cord-006229-7yoilsho	3102	9	national	national	JJ
cord-006229-7yoilsho	3102	10	toxicology	toxicology	NN
cord-006229-7yoilsho	3102	11	program	program	NN
cord-006229-7yoilsho	3102	12	(	(	-LRB-
cord-006229-7yoilsho	3102	13	NTP	NTP	NNP
cord-006229-7yoilsho	3102	14	)	)	-RRB-
cord-006229-7yoilsho	3102	15	and	and	CC
cord-006229-7yoilsho	3102	16	consisted	consist	VBD
cord-006229-7yoilsho	3102	17	of	of	IN
cord-006229-7yoilsho	3102	18	different	different	JJ
cord-006229-7yoilsho	3102	19	substance	substance	NN
cord-006229-7yoilsho	3102	20	classes	class	NNS
cord-006229-7yoilsho	3102	21	,	,	,
cord-006229-7yoilsho	3102	22	e.g.	e.g.	IN
cord-006229-7yoilsho	3102	23	organophosphates	organophosphate	NNS
cord-006229-7yoilsho	3102	24	,	,	,
cord-006229-7yoilsho	3102	25	organochlorines	organochlorine	NNS
cord-006229-7yoilsho	3102	26	,	,	,
cord-006229-7yoilsho	3102	27	drug	drug	NN
cord-006229-7yoilsho	3102	28	-	-	HYPH
cord-006229-7yoilsho	3102	29	like	like	JJ
cord-006229-7yoilsho	3102	30	compounds	compound	NNS
cord-006229-7yoilsho	3102	31	,	,	,
cord-006229-7yoilsho	3102	32	pesticides	pesticide	NNS
cord-006229-7yoilsho	3102	33	and	and	CC
cord-006229-7yoilsho	3102	34	polycyclic	polycyclic	JJ
cord-006229-7yoilsho	3102	35	aromatic	aromatic	JJ
cord-006229-7yoilsho	3102	36	hydrocarbons	hydrocarbon	NNS
cord-006229-7yoilsho	3102	37	(	(	-LRB-
cord-006229-7yoilsho	3102	38	PAHs	pah	NNS
cord-006229-7yoilsho	3102	39	)	)	-RRB-
cord-006229-7yoilsho	3102	40	.	.	.
cord-006229-7yoilsho	3103	1	Out	out	IN
cord-006229-7yoilsho	3103	2	of	of	IN
cord-006229-7yoilsho	3103	3	the	the	DT
cord-006229-7yoilsho	3103	4	tested	test	VBN
cord-006229-7yoilsho	3103	5	potential	potential	JJ
cord-006229-7yoilsho	3103	6	developmental	developmental	JJ
cord-006229-7yoilsho	3103	7	toxicants	toxicant	NNS
cord-006229-7yoilsho	3103	8	,	,	,
cord-006229-7yoilsho	3103	9	26	26	CD
cord-006229-7yoilsho	3103	10	compounds	compound	NNS
cord-006229-7yoilsho	3103	11	reduced	reduce	VBD
cord-006229-7yoilsho	3103	12	NCC	NCC	NNP
cord-006229-7yoilsho	3103	13	migration	migration	NN
cord-006229-7yoilsho	3103	14	at	at	IN
cord-006229-7yoilsho	3103	15	non	non	JJ
cord-006229-7yoilsho	3103	16	-	-	JJ
cord-006229-7yoilsho	3103	17	cytotoxic	cytotoxic	JJ
cord-006229-7yoilsho	3103	18	concentrations	concentration	NNS
cord-006229-7yoilsho	3103	19	.	.	.
cord-006229-7yoilsho	3104	1	Hit	hit	VB
cord-006229-7yoilsho	3104	2	-	-	HYPH
cord-006229-7yoilsho	3104	3	confirmation	confirmation	NN
cord-006229-7yoilsho	3104	4	testing	testing	NN
cord-006229-7yoilsho	3104	5	confirmed	confirm	VBD
cord-006229-7yoilsho	3104	6	23	23	CD
cord-006229-7yoilsho	3104	7	of	of	IN
cord-006229-7yoilsho	3104	8	the	the	DT
cord-006229-7yoilsho	3104	9	compounds	compound	NNS
cord-006229-7yoilsho	3104	10	as	as	IN
cord-006229-7yoilsho	3104	11	concentration	concentration	NN
cord-006229-7yoilsho	3104	12	-	-	HYPH
cord-006229-7yoilsho	3104	13	dependent	dependent	JJ
cord-006229-7yoilsho	3104	14	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	3104	15	of	of	IN
cord-006229-7yoilsho	3104	16	NCC	NCC	NNP
cord-006229-7yoilsho	3104	17	migration	migration	NN
cord-006229-7yoilsho	3104	18	.	.	.
cord-006229-7yoilsho	3105	1	Among	among	IN
cord-006229-7yoilsho	3105	2	the	the	DT
cord-006229-7yoilsho	3105	3	potential	potential	JJ
cord-006229-7yoilsho	3105	4	developmental	developmental	JJ
cord-006229-7yoilsho	3105	5	toxicants	toxicant	NNS
cord-006229-7yoilsho	3105	6	identified	identify	VBN
cord-006229-7yoilsho	3105	7	here	here	RB
cord-006229-7yoilsho	3105	8	,	,	,
cord-006229-7yoilsho	3105	9	there	there	EX
cord-006229-7yoilsho	3105	10	were	be	VBD
cord-006229-7yoilsho	3105	11	several	several	JJ
cord-006229-7yoilsho	3105	12	organophosphates	organophosphate	NNS
cord-006229-7yoilsho	3105	13	(	(	-LRB-
cord-006229-7yoilsho	3105	14	e.g.	e.g.	RB
cord-006229-7yoilsho	3105	15	chlorpyriphos	chlorpyriphos	JJ
cord-006229-7yoilsho	3105	16	)	)	-RRB-
cord-006229-7yoilsho	3105	17	and	and	CC
cord-006229-7yoilsho	3105	18	drug	drug	NN
cord-006229-7yoilsho	3105	19	-	-	HYPH
cord-006229-7yoilsho	3105	20	like	like	JJ
cord-006229-7yoilsho	3105	21	compounds	compound	NNS
cord-006229-7yoilsho	3105	22	as	as	RB
cord-006229-7yoilsho	3105	23	well	well	RB
cord-006229-7yoilsho	3105	24	as	as	IN
cord-006229-7yoilsho	3105	25	polybrominated	polybrominate	VBN
cord-006229-7yoilsho	3105	26	diphenyl	diphenyl	NNP
cord-006229-7yoilsho	3105	27	ethers	ether	NNS
cord-006229-7yoilsho	3105	28	(	(	-LRB-
cord-006229-7yoilsho	3105	29	PBDEs	pbde	NNS
cord-006229-7yoilsho	3105	30	)	)	-RRB-
cord-006229-7yoilsho	3105	31	and	and	CC
cord-006229-7yoilsho	3105	32	organochlorine	organochlorine	NNP
cord-006229-7yoilsho	3105	33	pesticides	pesticide	NNS
cord-006229-7yoilsho	3105	34	(	(	-LRB-
cord-006229-7yoilsho	3105	35	e.g.	e.g.	RB
cord-006229-7yoilsho	3105	36	DDT	DDT	NNP
cord-006229-7yoilsho	3105	37	and	and	CC
cord-006229-7yoilsho	3105	38	dieldrin	dieldrin	NNP
cord-006229-7yoilsho	3105	39	)	)	-RRB-
cord-006229-7yoilsho	3105	40	,	,	,
cord-006229-7yoilsho	3105	41	while	while	IN
cord-006229-7yoilsho	3105	42	none	none	NN
cord-006229-7yoilsho	3105	43	of	of	IN
cord-006229-7yoilsho	3105	44	the	the	DT
cord-006229-7yoilsho	3105	45	tested	test	VBN
cord-006229-7yoilsho	3105	46	PAHs	pah	NNS
cord-006229-7yoilsho	3105	47	inhibited	inhibit	VBD
cord-006229-7yoilsho	3105	48	NCC	NCC	NNP
cord-006229-7yoilsho	3105	49	migration	migration	NN
cord-006229-7yoilsho	3105	50	.	.	.
cord-006229-7yoilsho	3106	1	The	the	DT
cord-006229-7yoilsho	3106	2	negative	negative	JJ
cord-006229-7yoilsho	3106	3	controls	control	NNS
cord-006229-7yoilsho	3106	4	in	in	IN
cord-006229-7yoilsho	3106	5	the	the	DT
cord-006229-7yoilsho	3106	6	screening	screening	NN
cord-006229-7yoilsho	3106	7	library	library	NN
cord-006229-7yoilsho	3106	8	,	,	,
cord-006229-7yoilsho	3106	9	like	like	IN
cord-006229-7yoilsho	3106	10	acetylsalicylic	acetylsalicylic	JJ
cord-006229-7yoilsho	3106	11	acid	acid	NN
cord-006229-7yoilsho	3106	12	,	,	,
cord-006229-7yoilsho	3106	13	acetaminophen	acetaminophen	NN
cord-006229-7yoilsho	3106	14	and	and	CC
cord-006229-7yoilsho	3106	15	saccharin	saccharin	NN
cord-006229-7yoilsho	3106	16	,	,	,
cord-006229-7yoilsho	3106	17	proved	prove	VBN
cord-006229-7yoilsho	3106	18	to	to	TO
cord-006229-7yoilsho	3106	19	be	be	VB
cord-006229-7yoilsho	3106	20	non	non	JJ
cord-006229-7yoilsho	3106	21	-	-	JJ
cord-006229-7yoilsho	3106	22	toxic	toxic	JJ
cord-006229-7yoilsho	3106	23	.	.	.
cord-006229-7yoilsho	3107	1	Conclusion	conclusion	NN
cord-006229-7yoilsho	3107	2	/	/	SYM
cord-006229-7yoilsho	3107	3	Outlook	Outlook	NNP
cord-006229-7yoilsho	3107	4	:	:	:
cord-006229-7yoilsho	3108	1	The	the	DT
cord-006229-7yoilsho	3108	2	newly	newly	RB
cord-006229-7yoilsho	3108	3	established	establish	VBN
cord-006229-7yoilsho	3108	4	test	test	NN
cord-006229-7yoilsho	3108	5	system	system	NN
cord-006229-7yoilsho	3108	6	allows	allow	VBZ
cord-006229-7yoilsho	3108	7	screening	screening	NN
cord-006229-7yoilsho	3108	8	of	of	IN
cord-006229-7yoilsho	3108	9	potential	potential	JJ
cord-006229-7yoilsho	3108	10	developmental	developmental	JJ
cord-006229-7yoilsho	3108	11	toxicants	toxicant	NNS
cord-006229-7yoilsho	3108	12	in	in	IN
cord-006229-7yoilsho	3108	13	a	a	DT
cord-006229-7yoilsho	3108	14	high	high	JJ
cord-006229-7yoilsho	3108	15	throughput	throughput	NN
cord-006229-7yoilsho	3108	16	manner	manner	NN
cord-006229-7yoilsho	3108	17	for	for	IN
cord-006229-7yoilsho	3108	18	interference	interference	NN
cord-006229-7yoilsho	3108	19	with	with	IN
cord-006229-7yoilsho	3108	20	human	human	JJ
cord-006229-7yoilsho	3108	21	NCC	NCC	NNP
cord-006229-7yoilsho	3108	22	migration	migration	NN
cord-006229-7yoilsho	3108	23	.	.	.
cord-006229-7yoilsho	3109	1	Confirmation	confirmation	NN
cord-006229-7yoilsho	3109	2	in	in	IN
cord-006229-7yoilsho	3109	3	other	other	JJ
cord-006229-7yoilsho	3109	4	types	type	NNS
cord-006229-7yoilsho	3109	5	of	of	IN
cord-006229-7yoilsho	3109	6	migration	migration	NN
cord-006229-7yoilsho	3109	7	assays	assay	NNS
cord-006229-7yoilsho	3109	8	is	be	VBZ
cord-006229-7yoilsho	3109	9	ongoing	ongoing	JJ
cord-006229-7yoilsho	3109	10	,	,	,
cord-006229-7yoilsho	3109	11	and	and	CC
cord-006229-7yoilsho	3109	12	selected	select	VBN
cord-006229-7yoilsho	3109	13	compounds	compound	NNS
cord-006229-7yoilsho	3109	14	from	from	IN
cord-006229-7yoilsho	3109	15	amongst	amongst	IN
cord-006229-7yoilsho	3109	16	the	the	DT
cord-006229-7yoilsho	3109	17	screen	screen	NN
cord-006229-7yoilsho	3109	18	hits	hit	NNS
cord-006229-7yoilsho	3109	19	are	be	VBP
cord-006229-7yoilsho	3109	20	undergoing	undergo	VBG
cord-006229-7yoilsho	3109	21	mechanistic	mechanistic	JJ
cord-006229-7yoilsho	3109	22	evaluation	evaluation	NN
cord-006229-7yoilsho	3109	23	.	.	.
cord-006229-7yoilsho	3110	1	Oxidative	oxidative	JJ
cord-006229-7yoilsho	3110	2	stress	stress	NN
cord-006229-7yoilsho	3110	3	is	be	VBZ
cord-006229-7yoilsho	3110	4	regarded	regard	VBN
cord-006229-7yoilsho	3110	5	as	as	IN
cord-006229-7yoilsho	3110	6	a	a	DT
cord-006229-7yoilsho	3110	7	major	major	JJ
cord-006229-7yoilsho	3110	8	trigger	trigger	NN
cord-006229-7yoilsho	3110	9	for	for	IN
cord-006229-7yoilsho	3110	10	neuronal	neuronal	JJ
cord-006229-7yoilsho	3110	11	dysfunction	dysfunction	NN
cord-006229-7yoilsho	3110	12	and	and	CC
cord-006229-7yoilsho	3110	13	death	death	NN
cord-006229-7yoilsho	3110	14	in	in	IN
cord-006229-7yoilsho	3110	15	the	the	DT
cord-006229-7yoilsho	3110	16	ageing	age	VBG
cord-006229-7yoilsho	3110	17	brain	brain	NN
cord-006229-7yoilsho	3110	18	and	and	CC
cord-006229-7yoilsho	3110	19	in	in	IN
cord-006229-7yoilsho	3110	20	multiple	multiple	JJ
cord-006229-7yoilsho	3110	21	neurodegenerative	neurodegenerative	JJ
cord-006229-7yoilsho	3110	22	disorders	disorder	NNS
cord-006229-7yoilsho	3110	23	.	.	.
cord-006229-7yoilsho	3111	1	How	how	WRB
cord-006229-7yoilsho	3111	2	oxidative	oxidative	JJ
cord-006229-7yoilsho	3111	3	stress	stress	NN
cord-006229-7yoilsho	3111	4	mediates	mediate	VBZ
cord-006229-7yoilsho	3111	5	neuronal	neuronal	JJ
cord-006229-7yoilsho	3111	6	death	death	NN
cord-006229-7yoilsho	3111	7	and	and	CC
cord-006229-7yoilsho	3111	8	whether	whether	IN
cord-006229-7yoilsho	3111	9	the	the	DT
cord-006229-7yoilsho	3111	10	associated	associate	VBN
cord-006229-7yoilsho	3111	11	mechanisms	mechanism	NNS
cord-006229-7yoilsho	3111	12	are	be	VBP
cord-006229-7yoilsho	3111	13	accessible	accessible	JJ
cord-006229-7yoilsho	3111	14	for	for	IN
cord-006229-7yoilsho	3111	15	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	3111	16	intervention	intervention	NN
cord-006229-7yoilsho	3111	17	strategies	strategy	NNS
cord-006229-7yoilsho	3111	18	is	be	VBZ
cord-006229-7yoilsho	3111	19	not	not	RB
cord-006229-7yoilsho	3111	20	clarified	clarify	VBN
cord-006229-7yoilsho	3111	21	.	.	.
cord-006229-7yoilsho	3112	1	Increasing	increase	VBG
cord-006229-7yoilsho	3112	2	evidence	evidence	NN
cord-006229-7yoilsho	3112	3	suggests	suggest	VBZ
cord-006229-7yoilsho	3112	4	,	,	,
cord-006229-7yoilsho	3112	5	however	however	RB
cord-006229-7yoilsho	3112	6	,	,	,
cord-006229-7yoilsho	3112	7	that	that	IN
cord-006229-7yoilsho	3112	8	oxidative	oxidative	JJ
cord-006229-7yoilsho	3112	9	stress	stress	NN
cord-006229-7yoilsho	3112	10	triggers	trigger	VBZ
cord-006229-7yoilsho	3112	11	molecular	molecular	JJ
cord-006229-7yoilsho	3112	12	mechanisms	mechanism	NNS
cord-006229-7yoilsho	3112	13	of	of	IN
cord-006229-7yoilsho	3112	14	regulated	regulated	JJ
cord-006229-7yoilsho	3112	15	necrosis	necrosis	NN
cord-006229-7yoilsho	3112	16	that	that	WDT
cord-006229-7yoilsho	3112	17	involve	involve	VBP
cord-006229-7yoilsho	3112	18	the	the	DT
cord-006229-7yoilsho	3112	19	activation	activation	NN
cord-006229-7yoilsho	3112	20	of	of	IN
cord-006229-7yoilsho	3112	21	receptor	receptor	NN
cord-006229-7yoilsho	3112	22	interacting	interact	VBG
cord-006229-7yoilsho	3112	23	protein	protein	NN
cord-006229-7yoilsho	3112	24	1	1	CD
cord-006229-7yoilsho	3112	25	(	(	-LRB-
cord-006229-7yoilsho	3112	26	RIP1	RIP1	NNP
cord-006229-7yoilsho	3112	27	)	)	-RRB-
cord-006229-7yoilsho	3112	28	independently	independently	RB
cord-006229-7yoilsho	3112	29	of	of	IN
cord-006229-7yoilsho	3112	30	death	death	NN
cord-006229-7yoilsho	3112	31	receptor	receptor	NN
cord-006229-7yoilsho	3112	32	activation	activation	NN
cord-006229-7yoilsho	3112	33	.	.	.
cord-006229-7yoilsho	3113	1	Here	here	RB
cord-006229-7yoilsho	3113	2	,	,	,
cord-006229-7yoilsho	3113	3	we	-PRON-	PRP
cord-006229-7yoilsho	3113	4	show	show	VBP
cord-006229-7yoilsho	3113	5	that	that	IN
cord-006229-7yoilsho	3113	6	erastin	erastin	NN
cord-006229-7yoilsho	3113	7	-	-	HYPH
cord-006229-7yoilsho	3113	8	induced	induce	VBN
cord-006229-7yoilsho	3113	9	ferroptosis	ferroptosis	NN
cord-006229-7yoilsho	3113	10	which	which	WDT
cord-006229-7yoilsho	3113	11	involves	involve	VBZ
cord-006229-7yoilsho	3113	12	inhibition	inhibition	NN
cord-006229-7yoilsho	3113	13	of	of	IN
cord-006229-7yoilsho	3113	14	the	the	DT
cord-006229-7yoilsho	3113	15	glutamate	glutamate	NN
cord-006229-7yoilsho	3113	16	-	-	HYPH
cord-006229-7yoilsho	3113	17	cystein	cystein	NN
cord-006229-7yoilsho	3113	18	transporter	transporter	NN
cord-006229-7yoilsho	3113	19	(	(	-LRB-
cord-006229-7yoilsho	3113	20	Xc	Xc	NNP
cord-006229-7yoilsho	3113	21	-	-	HYPH
cord-006229-7yoilsho	3113	22	)	)	-RRB-
cord-006229-7yoilsho	3113	23	,	,	,
cord-006229-7yoilsho	3113	24	glutathione	glutathione	NN
cord-006229-7yoilsho	3113	25	depletion	depletion	NN
cord-006229-7yoilsho	3113	26	and	and	CC
cord-006229-7yoilsho	3113	27	lethal	lethal	JJ
cord-006229-7yoilsho	3113	28	formation	formation	NN
cord-006229-7yoilsho	3113	29	of	of	IN
cord-006229-7yoilsho	3113	30	reactive	reactive	JJ
cord-006229-7yoilsho	3113	31	oxygen	oxygen	NN
cord-006229-7yoilsho	3113	32	species	specie	NNS
cord-006229-7yoilsho	3113	33	(	(	-LRB-
cord-006229-7yoilsho	3113	34	ROS	ROS	NNP
cord-006229-7yoilsho	3113	35	)	)	-RRB-
cord-006229-7yoilsho	3113	36	1	1	CD
cord-006229-7yoilsho	3113	37	,	,	,
cord-006229-7yoilsho	3113	38	triggers	trigger	VBZ
cord-006229-7yoilsho	3113	39	mechanisms	mechanism	NNS
cord-006229-7yoilsho	3113	40	of	of	IN
cord-006229-7yoilsho	3113	41	regulated	regulated	JJ
cord-006229-7yoilsho	3113	42	necrosis	necrosis	NN
cord-006229-7yoilsho	3113	43	independent	independent	JJ
cord-006229-7yoilsho	3113	44	of	of	IN
cord-006229-7yoilsho	3113	45	TNFα	TNFα	NNP
cord-006229-7yoilsho	3113	46	-	-	HYPH
cord-006229-7yoilsho	3113	47	signaling	signal	VBG
cord-006229-7yoilsho	3113	48	.	.	.
cord-006229-7yoilsho	3114	1	In	in	IN
cord-006229-7yoilsho	3114	2	hippocampal	hippocampal	JJ
cord-006229-7yoilsho	3114	3	HT-22	HT-22	NNP
cord-006229-7yoilsho	3114	4	cells	cell	NNS
cord-006229-7yoilsho	3114	5	erastin	erastin	NNP
cord-006229-7yoilsho	3114	6	promotes	promote	VBZ
cord-006229-7yoilsho	3114	7	activation	activation	NN
cord-006229-7yoilsho	3114	8	of	of	IN
cord-006229-7yoilsho	3114	9	RIP1	RIP1	NNP
cord-006229-7yoilsho	3114	10	and	and	CC
cord-006229-7yoilsho	3114	11	subsequent	subsequent	JJ
cord-006229-7yoilsho	3114	12	RIP1-RIP3	RIP1-RIP3	NNP
cord-006229-7yoilsho	3114	13	necrosome	necrosome	NN
cord-006229-7yoilsho	3114	14	formation	formation	NN
cord-006229-7yoilsho	3114	15	which	which	WDT
cord-006229-7yoilsho	3114	16	has	have	VBZ
cord-006229-7yoilsho	3114	17	been	be	VBN
cord-006229-7yoilsho	3114	18	investigated	investigate	VBN
cord-006229-7yoilsho	3114	19	as	as	IN
cord-006229-7yoilsho	3114	20	a	a	DT
cord-006229-7yoilsho	3114	21	hallmark	hallmark	NN
cord-006229-7yoilsho	3114	22	of	of	IN
cord-006229-7yoilsho	3114	23	regulated	regulated	JJ
cord-006229-7yoilsho	3114	24	necrosis	necrosis	NN
cord-006229-7yoilsho	3114	25	2	2	CD
cord-006229-7yoilsho	3114	26	.	.	.
cord-006229-7yoilsho	3115	1	In	in	IN
cord-006229-7yoilsho	3115	2	fact	fact	NN
cord-006229-7yoilsho	3115	3	,	,	,
cord-006229-7yoilsho	3115	4	silencing	silencing	NN
cord-006229-7yoilsho	3115	5	of	of	IN
cord-006229-7yoilsho	3115	6	RIP1	RIP1	NNP
cord-006229-7yoilsho	3115	7	by	by	IN
cord-006229-7yoilsho	3115	8	siRNA	siRNA	NNP
cord-006229-7yoilsho	3115	9	or	or	CC
cord-006229-7yoilsho	3115	10	by	by	IN
cord-006229-7yoilsho	3115	11	the	the	DT
cord-006229-7yoilsho	3115	12	RIP1	RIP1	NNP
cord-006229-7yoilsho	3115	13	inhibitor	inhibitor	NN
cord-006229-7yoilsho	3115	14	necrostatin-1	necrostatin-1	NNP
cord-006229-7yoilsho	3115	15	prevents	prevent	VBZ
cord-006229-7yoilsho	3115	16	ferroptosis	ferroptosis	NN
cord-006229-7yoilsho	3115	17	-	-	HYPH
cord-006229-7yoilsho	3115	18	induced	induce	VBN
cord-006229-7yoilsho	3115	19	cell	cell	NN
cord-006229-7yoilsho	3115	20	death	death	NN
cord-006229-7yoilsho	3115	21	whereas	whereas	IN
cord-006229-7yoilsho	3115	22	the	the	DT
cord-006229-7yoilsho	3115	23	ferroptosis	ferroptosis	NN
cord-006229-7yoilsho	3115	24	inhibitor	inhibitor	NN
cord-006229-7yoilsho	3115	25	ferrostatin-1	ferrostatin-1	NNP
cord-006229-7yoilsho	3115	26	fails	fail	VBZ
cord-006229-7yoilsho	3115	27	to	to	TO
cord-006229-7yoilsho	3115	28	protect	protect	VB
cord-006229-7yoilsho	3115	29	cells	cell	NNS
cord-006229-7yoilsho	3115	30	against	against	IN
cord-006229-7yoilsho	3115	31	TNFα	TNFα	NNS
cord-006229-7yoilsho	3115	32	-	-	HYPH
cord-006229-7yoilsho	3115	33	induced	induce	VBN
cord-006229-7yoilsho	3115	34	classical	classical	JJ
cord-006229-7yoilsho	3115	35	necroptosis	necroptosis	NN
cord-006229-7yoilsho	3115	36	,	,	,
cord-006229-7yoilsho	3115	37	a	a	DT
cord-006229-7yoilsho	3115	38	form	form	NN
cord-006229-7yoilsho	3115	39	of	of	IN
cord-006229-7yoilsho	3115	40	programmed	programmed	JJ
cord-006229-7yoilsho	3115	41	cell	cell	NN
cord-006229-7yoilsho	3115	42	death	death	NN
cord-006229-7yoilsho	3115	43	that	that	WDT
cord-006229-7yoilsho	3115	44	is	be	VBZ
cord-006229-7yoilsho	3115	45	mediated	mediate	VBN
cord-006229-7yoilsho	3115	46	by	by	IN
cord-006229-7yoilsho	3115	47	receptor	receptor	NN
cord-006229-7yoilsho	3115	48	interacting	interact	VBG
cord-006229-7yoilsho	3115	49	protein-1	protein-1	NNP
cord-006229-7yoilsho	3115	50	(	(	-LRB-
cord-006229-7yoilsho	3115	51	RIP1	RIP1	NNP
cord-006229-7yoilsho	3115	52	)	)	-RRB-
cord-006229-7yoilsho	3115	53	and	and	CC
cord-006229-7yoilsho	3115	54	RIP3	RIP3	NNP
cord-006229-7yoilsho	3115	55	kinases	kinase	NNS
cord-006229-7yoilsho	3115	56	downstream	downstream	RB
cord-006229-7yoilsho	3115	57	of	of	IN
cord-006229-7yoilsho	3115	58	death	death	NN
cord-006229-7yoilsho	3115	59	receptor	receptor	NN
cord-006229-7yoilsho	3115	60	activation	activation	NN
cord-006229-7yoilsho	3115	61	(	(	-LRB-
cord-006229-7yoilsho	3115	62	e.g.	e.g.	JJ
cord-006229-7yoilsho	3115	63	tumor	tumor	NN
cord-006229-7yoilsho	3115	64	necrosis	necrosis	NN
cord-006229-7yoilsho	3115	65	factor	factor	NN
cord-006229-7yoilsho	3115	66	receptor	receptor	NN
cord-006229-7yoilsho	3115	67	TNFR	TNFR	NNP
cord-006229-7yoilsho	3115	68	)	)	-RRB-
cord-006229-7yoilsho	3115	69	2	2	CD
cord-006229-7yoilsho	3115	70	,	,	,
cord-006229-7yoilsho	3115	71	3	3	CD
cord-006229-7yoilsho	3115	72	.	.	.
cord-006229-7yoilsho	3116	1	Recently	recently	RB
cord-006229-7yoilsho	3116	2	,	,	,
cord-006229-7yoilsho	3116	3	a	a	DT
cord-006229-7yoilsho	3116	4	genome	genome	NN
cord-006229-7yoilsho	3116	5	-	-	HYPH
cord-006229-7yoilsho	3116	6	wide	wide	JJ
cord-006229-7yoilsho	3116	7	siRNA	siRNA	NNP
cord-006229-7yoilsho	3116	8	screen	screen	NN
cord-006229-7yoilsho	3116	9	linked	link	VBD
cord-006229-7yoilsho	3116	10	cylindromatosis	cylindromatosis	NN
cord-006229-7yoilsho	3116	11	(	(	-LRB-
cord-006229-7yoilsho	3116	12	CYLD	CYLD	NNP
cord-006229-7yoilsho	3116	13	)	)	-RRB-
cord-006229-7yoilsho	3116	14	to	to	IN
cord-006229-7yoilsho	3116	15	RIP1	rip1	$
cord-006229-7yoilsho	3116	16	/	/	SYM
cord-006229-7yoilsho	3116	17	RIP3-dependent	RIP3-dependent	NNP
cord-006229-7yoilsho	3116	18	necroptosis	necroptosis	NNP
cord-006229-7yoilsho	3116	19	4	4	CD
cord-006229-7yoilsho	3116	20	and	and	CC
cord-006229-7yoilsho	3116	21	also	also	RB
cord-006229-7yoilsho	3116	22	in	in	IN
cord-006229-7yoilsho	3116	23	the	the	DT
cord-006229-7yoilsho	3116	24	present	present	JJ
cord-006229-7yoilsho	3116	25	paradigm	paradigm	NN
cord-006229-7yoilsho	3116	26	of	of	IN
cord-006229-7yoilsho	3116	27	ferroptosis	ferroptosis	NN
cord-006229-7yoilsho	3117	1	,	,	,
cord-006229-7yoilsho	3117	2	CYLD	CYLD	NNP
cord-006229-7yoilsho	3117	3	depletion	depletion	NN
cord-006229-7yoilsho	3117	4	promotes	promote	VBZ
cord-006229-7yoilsho	3117	5	neuronal	neuronal	JJ
cord-006229-7yoilsho	3117	6	survival	survival	NN
cord-006229-7yoilsho	3117	7	and	and	CC
cord-006229-7yoilsho	3117	8	decreases	decrease	VBZ
cord-006229-7yoilsho	3117	9	RIP1-RIP3	RIP1-RIP3	NNP
cord-006229-7yoilsho	3117	10	complex	complex	JJ
cord-006229-7yoilsho	3117	11	formation	formation	NN
cord-006229-7yoilsho	3117	12	,	,	,
cord-006229-7yoilsho	3117	13	suggesting	suggest	VBG
cord-006229-7yoilsho	3117	14	a	a	DT
cord-006229-7yoilsho	3117	15	role	role	NN
cord-006229-7yoilsho	3117	16	of	of	IN
cord-006229-7yoilsho	3117	17	CYLD	CYLD	NNP
cord-006229-7yoilsho	3117	18	in	in	IN
cord-006229-7yoilsho	3117	19	intrinsic	intrinsic	JJ
cord-006229-7yoilsho	3117	20	pathways	pathway	NNS
cord-006229-7yoilsho	3117	21	of	of	IN
cord-006229-7yoilsho	3117	22	regulated	regulated	JJ
cord-006229-7yoilsho	3117	23	necrosis	necrosis	NN
cord-006229-7yoilsho	3117	24	triggered	trigger	VBN
cord-006229-7yoilsho	3117	25	by	by	IN
cord-006229-7yoilsho	3117	26	oxidative	oxidative	JJ
cord-006229-7yoilsho	3117	27	stress	stress	NN
cord-006229-7yoilsho	3117	28	.	.	.
cord-006229-7yoilsho	3118	1	The	the	DT
cord-006229-7yoilsho	3118	2	NS5A	NS5A	NNP
cord-006229-7yoilsho	3119	1	inhibitor	inhibitor	NNP
cord-006229-7yoilsho	3119	2	daclatasvir	daclatasvir	NNP
cord-006229-7yoilsho	3119	3	is	be	VBZ
cord-006229-7yoilsho	3119	4	used	use	VBN
cord-006229-7yoilsho	3119	5	in	in	IN
cord-006229-7yoilsho	3119	6	combination	combination	NN
cord-006229-7yoilsho	3119	7	with	with	IN
cord-006229-7yoilsho	3119	8	other	other	JJ
cord-006229-7yoilsho	3119	9	antivirals	antiviral	NNS
cord-006229-7yoilsho	3119	10	such	such	JJ
cord-006229-7yoilsho	3119	11	as	as	IN
cord-006229-7yoilsho	3119	12	the	the	DT
cord-006229-7yoilsho	3119	13	polymerase	polymerase	NN
cord-006229-7yoilsho	3119	14	inhibitor	inhibitor	NN
cord-006229-7yoilsho	3119	15	sofosbuvir	sofosbuvir	NN
cord-006229-7yoilsho	3119	16	for	for	IN
cord-006229-7yoilsho	3119	17	treatment	treatment	NN
cord-006229-7yoilsho	3119	18	of	of	IN
cord-006229-7yoilsho	3119	19	chronic	chronic	JJ
cord-006229-7yoilsho	3119	20	infection	infection	NN
cord-006229-7yoilsho	3119	21	with	with	IN
cord-006229-7yoilsho	3119	22	the	the	DT
cord-006229-7yoilsho	3119	23	hepatitis	hepatitis	NN
cord-006229-7yoilsho	3119	24	C	C	NNP
cord-006229-7yoilsho	3119	25	virus	virus	NN
cord-006229-7yoilsho	3119	26	.	.	.
cord-006229-7yoilsho	3120	1	Daclatasvir	Daclatasvir	NNP
cord-006229-7yoilsho	3120	2	is	be	VBZ
cord-006229-7yoilsho	3120	3	embryotoxic	embryotoxic	JJ
cord-006229-7yoilsho	3120	4	and	and	CC
cord-006229-7yoilsho	3120	5	teratogenic	teratogenic	JJ
cord-006229-7yoilsho	3120	6	in	in	IN
cord-006229-7yoilsho	3120	7	rats	rat	NNS
cord-006229-7yoilsho	3120	8	and	and	CC
cord-006229-7yoilsho	3120	9	rabbits	rabbit	NNS
cord-006229-7yoilsho	3120	10	at	at	IN
cord-006229-7yoilsho	3120	11	exposures	exposure	NNS
cord-006229-7yoilsho	3120	12	at	at	IN
cord-006229-7yoilsho	3120	13	or	or	CC
cord-006229-7yoilsho	3120	14	above	above	IN
cord-006229-7yoilsho	3120	15	the	the	DT
cord-006229-7yoilsho	3120	16	clinical	clinical	JJ
cord-006229-7yoilsho	3120	17	exposure	exposure	NN
cord-006229-7yoilsho	3120	18	.	.	.
cord-006229-7yoilsho	3121	1	In	in	IN
cord-006229-7yoilsho	3121	2	contrast	contrast	NN
cord-006229-7yoilsho	3121	3	,	,	,
cord-006229-7yoilsho	3121	4	no	no	DT
cord-006229-7yoilsho	3121	5	teratogenic	teratogenic	JJ
cord-006229-7yoilsho	3121	6	effects	effect	NNS
cord-006229-7yoilsho	3121	7	were	be	VBD
cord-006229-7yoilsho	3121	8	observed	observe	VBN
cord-006229-7yoilsho	3121	9	in	in	IN
cord-006229-7yoilsho	3121	10	rat	rat	NN
cord-006229-7yoilsho	3121	11	and	and	CC
cord-006229-7yoilsho	3121	12	rabbit	rabbit	NN
cord-006229-7yoilsho	3121	13	developmental	developmental	JJ
cord-006229-7yoilsho	3121	14	toxicity	toxicity	NN
cord-006229-7yoilsho	3121	15	studies	study	NNS
cord-006229-7yoilsho	3121	16	with	with	IN
cord-006229-7yoilsho	3121	17	ledipasvir	ledipasvir	NNP
cord-006229-7yoilsho	3121	18	,	,	,
cord-006229-7yoilsho	3121	19	another	another	DT
cord-006229-7yoilsho	3121	20	NS5A	NS5A	NNP
cord-006229-7yoilsho	3121	21	inhibitor	inhibitor	NN
cord-006229-7yoilsho	3121	22	.	.	.
cord-006229-7yoilsho	3122	1	We	-PRON-	PRP
cord-006229-7yoilsho	3122	2	studied	study	VBD
cord-006229-7yoilsho	3122	3	these	these	DT
cord-006229-7yoilsho	3122	4	compounds	compound	NNS
cord-006229-7yoilsho	3122	5	in	in	IN
cord-006229-7yoilsho	3122	6	the	the	DT
cord-006229-7yoilsho	3122	7	embryonic	embryonic	JJ
cord-006229-7yoilsho	3122	8	stem	stem	NN
cord-006229-7yoilsho	3122	9	cell	cell	NN
cord-006229-7yoilsho	3122	10	test	test	NN
cord-006229-7yoilsho	3122	11	(	(	-LRB-
cord-006229-7yoilsho	3122	12	EST	EST	NNP
cord-006229-7yoilsho	3122	13	)	)	-RRB-
cord-006229-7yoilsho	3122	14	alone	alone	RB
cord-006229-7yoilsho	3122	15	and	and	CC
cord-006229-7yoilsho	3122	16	in	in	IN
cord-006229-7yoilsho	3122	17	combination	combination	NN
cord-006229-7yoilsho	3122	18	with	with	IN
cord-006229-7yoilsho	3122	19	sofosbuvir	sofosbuvir	NNP
cord-006229-7yoilsho	3122	20	.	.	.
cord-006229-7yoilsho	3123	1	The	the	DT
cord-006229-7yoilsho	3123	2	NS5A	NS5A	NNP
cord-006229-7yoilsho	3123	3	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	3123	4	were	be	VBD
cord-006229-7yoilsho	3123	5	obtained	obtain	VBN
cord-006229-7yoilsho	3123	6	from	from	IN
cord-006229-7yoilsho	3123	7	Selleckchem	Selleckchem	NNP
cord-006229-7yoilsho	3123	8	,	,	,
cord-006229-7yoilsho	3123	9	the	the	DT
cord-006229-7yoilsho	3123	10	main	main	JJ
cord-006229-7yoilsho	3123	11	metabolite	metabolite	NN
cord-006229-7yoilsho	3123	12	of	of	IN
cord-006229-7yoilsho	3123	13	sofosbuvir	sofosbuvir	NN
cord-006229-7yoilsho	3123	14	,	,	,
cord-006229-7yoilsho	3123	15	PSI-6202	PSI-6202	NNP
cord-006229-7yoilsho	3123	16	,	,	,
cord-006229-7yoilsho	3123	17	was	be	VBD
cord-006229-7yoilsho	3123	18	from	from	IN
cord-006229-7yoilsho	3123	19	MedChem	MedChem	NNP
cord-006229-7yoilsho	3123	20	Express	Express	NNP
cord-006229-7yoilsho	3123	21	.	.	.
cord-006229-7yoilsho	3124	1	Murine	murine	JJ
cord-006229-7yoilsho	3124	2	embryonic	embryonic	JJ
cord-006229-7yoilsho	3124	3	stem	stem	NN
cord-006229-7yoilsho	3124	4	cells	cell	NNS
cord-006229-7yoilsho	3124	5	(	(	-LRB-
cord-006229-7yoilsho	3124	6	ES	ES	NNP
cord-006229-7yoilsho	3124	7	-	-	HYPH
cord-006229-7yoilsho	3124	8	D3	D3	NNP
cord-006229-7yoilsho	3124	9	)	)	-RRB-
cord-006229-7yoilsho	3124	10	were	be	VBD
cord-006229-7yoilsho	3124	11	obtained	obtain	VBN
cord-006229-7yoilsho	3124	12	from	from	IN
cord-006229-7yoilsho	3124	13	ATCC	ATCC	NNP
cord-006229-7yoilsho	3124	14	.	.	.
cord-006229-7yoilsho	3125	1	They	-PRON-	PRP
cord-006229-7yoilsho	3125	2	were	be	VBD
cord-006229-7yoilsho	3125	3	kept	keep	VBN
cord-006229-7yoilsho	3125	4	in	in	IN
cord-006229-7yoilsho	3125	5	Iscove	Iscove	NNP
cord-006229-7yoilsho	3125	6	's	's	POS
cord-006229-7yoilsho	3125	7	Modified	modify	VBN
cord-006229-7yoilsho	3125	8	Dulbecco	Dulbecco	NNP
cord-006229-7yoilsho	3125	9	's	's	POS
cord-006229-7yoilsho	3125	10	Medium	medium	NN
cord-006229-7yoilsho	3125	11	(	(	-LRB-
cord-006229-7yoilsho	3125	12	IMDM	IMDM	NNP
cord-006229-7yoilsho	3125	13	)	)	-RRB-
cord-006229-7yoilsho	3125	14	.	.	.
cord-006229-7yoilsho	3126	1	Substances	substance	NNS
cord-006229-7yoilsho	3126	2	were	be	VBD
cord-006229-7yoilsho	3126	3	dissolved	dissolve	VBN
cord-006229-7yoilsho	3126	4	in	in	IN
cord-006229-7yoilsho	3126	5	DMSO	DMSO	NNP
cord-006229-7yoilsho	3126	6	at	at	IN
cord-006229-7yoilsho	3126	7	a	a	DT
cord-006229-7yoilsho	3126	8	final	final	JJ
cord-006229-7yoilsho	3126	9	DMSO	dmso	NN
cord-006229-7yoilsho	3126	10	-	-	HYPH
cord-006229-7yoilsho	3126	11	concentration	concentration	NN
cord-006229-7yoilsho	3126	12	of	of	IN
cord-006229-7yoilsho	3126	13	0.1	0.1	CD
cord-006229-7yoilsho	3126	14	%	%	NN
cord-006229-7yoilsho	3126	15	in	in	IN
cord-006229-7yoilsho	3126	16	the	the	DT
cord-006229-7yoilsho	3126	17	culture	culture	NN
cord-006229-7yoilsho	3126	18	medium	medium	NN
cord-006229-7yoilsho	3126	19	.	.	.
cord-006229-7yoilsho	3127	1	A	a	DT
cord-006229-7yoilsho	3127	2	cytotoxicity	cytotoxicity	NN
cord-006229-7yoilsho	3127	3	assay	assay	NN
cord-006229-7yoilsho	3127	4	as	as	RB
cord-006229-7yoilsho	3127	5	well	well	RB
cord-006229-7yoilsho	3127	6	as	as	IN
cord-006229-7yoilsho	3127	7	a	a	DT
cord-006229-7yoilsho	3127	8	differentiation	differentiation	NN
cord-006229-7yoilsho	3127	9	assay	assay	NN
cord-006229-7yoilsho	3127	10	were	be	VBD
cord-006229-7yoilsho	3127	11	performed	perform	VBN
cord-006229-7yoilsho	3127	12	.	.	.
cord-006229-7yoilsho	3128	1	After	after	IN
cord-006229-7yoilsho	3128	2	10	10	CD
cord-006229-7yoilsho	3128	3	days	day	NNS
cord-006229-7yoilsho	3128	4	in	in	IN
cord-006229-7yoilsho	3128	5	culture	culture	NN
cord-006229-7yoilsho	3128	6	the	the	DT
cord-006229-7yoilsho	3128	7	cells	cell	NNS
cord-006229-7yoilsho	3128	8	were	be	VBD
cord-006229-7yoilsho	3128	9	evaluated	evaluate	VBN
cord-006229-7yoilsho	3128	10	.	.	.
cord-006229-7yoilsho	3129	1	Cytotoxicity	Cytotoxicity	NNP
cord-006229-7yoilsho	3129	2	was	be	VBD
cord-006229-7yoilsho	3129	3	measured	measure	VBN
cord-006229-7yoilsho	3129	4	by	by	IN
cord-006229-7yoilsho	3129	5	an	an	DT
cord-006229-7yoilsho	3129	6	MTT	MTT	NNP
cord-006229-7yoilsho	3129	7	test	test	NN
cord-006229-7yoilsho	3129	8	.	.	.
cord-006229-7yoilsho	3130	1	Differentiation	differentiation	NN
cord-006229-7yoilsho	3130	2	into	into	IN
cord-006229-7yoilsho	3130	3	contracting	contracting	NN
cord-006229-7yoilsho	3130	4	myocardial	myocardial	JJ
cord-006229-7yoilsho	3130	5	cells	cell	NNS
cord-006229-7yoilsho	3130	6	was	be	VBD
cord-006229-7yoilsho	3130	7	determined	determine	VBN
cord-006229-7yoilsho	3130	8	using	use	VBG
cord-006229-7yoilsho	3130	9	direct	direct	JJ
cord-006229-7yoilsho	3130	10	phase	phase	NN
cord-006229-7yoilsho	3130	11	contrast	contrast	NN
cord-006229-7yoilsho	3130	12	microscopy	microscopy	NNS
cord-006229-7yoilsho	3130	13	.	.	.
cord-006229-7yoilsho	3131	1	The	the	DT
cord-006229-7yoilsho	3131	2	substances	substance	NNS
cord-006229-7yoilsho	3131	3	were	be	VBD
cord-006229-7yoilsho	3131	4	tested	test	VBN
cord-006229-7yoilsho	3131	5	at	at	IN
cord-006229-7yoilsho	3131	6	concentrations	concentration	NNS
cord-006229-7yoilsho	3131	7	between	between	IN
cord-006229-7yoilsho	3131	8	0.1	0.1	CD
cord-006229-7yoilsho	3131	9	and	and	CC
cord-006229-7yoilsho	3131	10	30	30	CD
cord-006229-7yoilsho	3131	11	mg	mg	NNP
cord-006229-7yoilsho	3131	12	/	/	SYM
cord-006229-7yoilsho	3131	13	l	l	NNP
cord-006229-7yoilsho	3131	14	,	,	,
cord-006229-7yoilsho	3131	15	which	which	WDT
cord-006229-7yoilsho	3131	16	is	be	VBZ
cord-006229-7yoilsho	3131	17	a	a	DT
cord-006229-7yoilsho	3131	18	broad	broad	JJ
cord-006229-7yoilsho	3131	19	coverage	coverage	NN
cord-006229-7yoilsho	3131	20	of	of	IN
cord-006229-7yoilsho	3131	21	the	the	DT
cord-006229-7yoilsho	3131	22	therapeutically	therapeutically	RB
cord-006229-7yoilsho	3131	23	relevant	relevant	JJ
cord-006229-7yoilsho	3131	24	concentrations	concentration	NNS
cord-006229-7yoilsho	3131	25	reached	reach	VBN
cord-006229-7yoilsho	3131	26	in	in	IN
cord-006229-7yoilsho	3131	27	patients	patient	NNS
cord-006229-7yoilsho	3131	28	.	.	.
cord-006229-7yoilsho	3132	1	At	at	IN
cord-006229-7yoilsho	3132	2	a	a	DT
cord-006229-7yoilsho	3132	3	concentration	concentration	NN
cord-006229-7yoilsho	3132	4	of	of	IN
cord-006229-7yoilsho	3132	5	10	10	CD
cord-006229-7yoilsho	3132	6	mg	mg	NNP
cord-006229-7yoilsho	3132	7	daclatasvir	daclatasvir	NNP
cord-006229-7yoilsho	3132	8	/	/	SYM
cord-006229-7yoilsho	3132	9	l	l	NN
cord-006229-7yoilsho	3132	10	medium	medium	NN
cord-006229-7yoilsho	3132	11	and	and	CC
cord-006229-7yoilsho	3132	12	higher	high	JJR
cord-006229-7yoilsho	3132	13	the	the	DT
cord-006229-7yoilsho	3132	14	substance	substance	NN
cord-006229-7yoilsho	3132	15	inhibited	inhibit	VBN
cord-006229-7yoilsho	3132	16	differentiation	differentiation	NN
cord-006229-7yoilsho	3132	17	of	of	IN
cord-006229-7yoilsho	3132	18	cells	cell	NNS
cord-006229-7yoilsho	3132	19	.	.	.
cord-006229-7yoilsho	3133	1	We	-PRON-	PRP
cord-006229-7yoilsho	3133	2	observed	observe	VBD
cord-006229-7yoilsho	3133	3	contracting	contracting	NN
cord-006229-7yoilsho	3133	4	myocytes	myocyte	NNS
cord-006229-7yoilsho	3133	5	in	in	IN
cord-006229-7yoilsho	3133	6	23	23	CD
cord-006229-7yoilsho	3133	7	,	,	,
cord-006229-7yoilsho	3133	8	22	22	CD
cord-006229-7yoilsho	3133	9	and	and	CC
cord-006229-7yoilsho	3133	10	2	2	CD
cord-006229-7yoilsho	3133	11	wells	well	NNS
cord-006229-7yoilsho	3133	12	out	out	IN
cord-006229-7yoilsho	3133	13	of	of	IN
cord-006229-7yoilsho	3133	14	24	24	CD
cord-006229-7yoilsho	3133	15	wells	well	NNS
cord-006229-7yoilsho	3133	16	in	in	IN
cord-006229-7yoilsho	3133	17	total	total	NN
cord-006229-7yoilsho	3133	18	at	at	IN
cord-006229-7yoilsho	3133	19	concentrations	concentration	NNS
cord-006229-7yoilsho	3133	20	of	of	IN
cord-006229-7yoilsho	3133	21	1	1	CD
cord-006229-7yoilsho	3133	22	,	,	,
cord-006229-7yoilsho	3133	23	3	3	CD
cord-006229-7yoilsho	3133	24	and	and	CC
cord-006229-7yoilsho	3133	25	10	10	CD
cord-006229-7yoilsho	3133	26	mg	mg	NNP
cord-006229-7yoilsho	3133	27	/	/	SYM
cord-006229-7yoilsho	3133	28	l	l	NN
cord-006229-7yoilsho	3133	29	.	.	.
cord-006229-7yoilsho	3134	1	At	at	IN
cord-006229-7yoilsho	3134	2	30	30	CD
cord-006229-7yoilsho	3134	3	mg	mg	NN
cord-006229-7yoilsho	3134	4	/	/	SYM
cord-006229-7yoilsho	3134	5	l	l	NN
cord-006229-7yoilsho	3135	1	no	no	DT
cord-006229-7yoilsho	3135	2	differentiation	differentiation	NN
cord-006229-7yoilsho	3135	3	was	be	VBD
cord-006229-7yoilsho	3135	4	observed	observe	VBN
cord-006229-7yoilsho	3135	5	.	.	.
cord-006229-7yoilsho	3136	1	Effects	effect	NNS
cord-006229-7yoilsho	3136	2	on	on	IN
cord-006229-7yoilsho	3136	3	cell	cell	NN
cord-006229-7yoilsho	3136	4	viability	viability	NN
cord-006229-7yoilsho	3136	5	were	be	VBD
cord-006229-7yoilsho	3136	6	observed	observe	VBN
cord-006229-7yoilsho	3136	7	at	at	IN
cord-006229-7yoilsho	3136	8	30	30	CD
cord-006229-7yoilsho	3136	9	mg	mg	NNP
cord-006229-7yoilsho	3136	10	/	/	SYM
cord-006229-7yoilsho	3136	11	l	l	NN
cord-006229-7yoilsho	3136	12	.	.	.
cord-006229-7yoilsho	3137	1	Unexpectedly	unexpectedly	RB
cord-006229-7yoilsho	3137	2	,	,	,
cord-006229-7yoilsho	3137	3	we	-PRON-	PRP
cord-006229-7yoilsho	3137	4	found	find	VBD
cord-006229-7yoilsho	3137	5	a	a	DT
cord-006229-7yoilsho	3137	6	higher	high	JJR
cord-006229-7yoilsho	3137	7	potency	potency	NN
cord-006229-7yoilsho	3137	8	with	with	IN
cord-006229-7yoilsho	3137	9	ledipasvir	ledipasvir	NNS
cord-006229-7yoilsho	3137	10	.	.	.
cord-006229-7yoilsho	3138	1	At	at	IN
cord-006229-7yoilsho	3138	2	the	the	DT
cord-006229-7yoilsho	3138	3	low	low	JJ
cord-006229-7yoilsho	3138	4	,	,	,
cord-006229-7yoilsho	3138	5	therapeutically	therapeutically	RB
cord-006229-7yoilsho	3138	6	relevant	relevant	JJ
cord-006229-7yoilsho	3138	7	concentration	concentration	NN
cord-006229-7yoilsho	3138	8	of	of	IN
cord-006229-7yoilsho	3138	9	1	1	CD
cord-006229-7yoilsho	3138	10	mg	mg	NNP
cord-006229-7yoilsho	3138	11	/	/	SYM
cord-006229-7yoilsho	3138	12	l	l	NN
cord-006229-7yoilsho	3138	13	this	this	DT
cord-006229-7yoilsho	3139	1	NSA5-inibitor	NSA5-inibitor	NNP
cord-006229-7yoilsho	3139	2	showed	show	VBD
cord-006229-7yoilsho	3139	3	a	a	DT
cord-006229-7yoilsho	3139	4	clear	clear	JJ
cord-006229-7yoilsho	3139	5	impact	impact	NN
cord-006229-7yoilsho	3139	6	on	on	IN
cord-006229-7yoilsho	3139	7	differentiation	differentiation	NN
cord-006229-7yoilsho	3139	8	with	with	IN
cord-006229-7yoilsho	3139	9	6	6	CD
cord-006229-7yoilsho	3139	10	out	out	IN
cord-006229-7yoilsho	3139	11	of	of	IN
cord-006229-7yoilsho	3139	12	24	24	CD
cord-006229-7yoilsho	3139	13	wells	well	NNS
cord-006229-7yoilsho	3139	14	affected	affect	VBN
cord-006229-7yoilsho	3139	15	and	and	CC
cord-006229-7yoilsho	3139	16	no	no	DT
cord-006229-7yoilsho	3139	17	differentiation	differentiation	NN
cord-006229-7yoilsho	3139	18	at	at	IN
cord-006229-7yoilsho	3139	19	higher	high	JJR
cord-006229-7yoilsho	3139	20	concentrations	concentration	NNS
cord-006229-7yoilsho	3139	21	.	.	.
cord-006229-7yoilsho	3140	1	Addition	addition	NN
cord-006229-7yoilsho	3140	2	of	of	IN
cord-006229-7yoilsho	3140	3	sofosbuvir	sofosbuvir	NN
cord-006229-7yoilsho	3140	4	or	or	CC
cord-006229-7yoilsho	3140	5	its	-PRON-	PRP$
cord-006229-7yoilsho	3140	6	main	main	JJ
cord-006229-7yoilsho	3140	7	metabolite	metabolite	NN
cord-006229-7yoilsho	3140	8	PSI-6206	PSI-6206	NNP
cord-006229-7yoilsho	3140	9	at	at	IN
cord-006229-7yoilsho	3140	10	concentrations	concentration	NNS
cord-006229-7yoilsho	3140	11	up	up	IN
cord-006229-7yoilsho	3140	12	to	to	TO
cord-006229-7yoilsho	3140	13	30	30	CD
cord-006229-7yoilsho	3140	14	mg	mg	NN
cord-006229-7yoilsho	3140	15	/	/	SYM
cord-006229-7yoilsho	3140	16	l	l	NNP
cord-006229-7yoilsho	3140	17	had	have	VBD
cord-006229-7yoilsho	3140	18	no	no	DT
cord-006229-7yoilsho	3140	19	influence	influence	NN
cord-006229-7yoilsho	3140	20	on	on	IN
cord-006229-7yoilsho	3140	21	the	the	DT
cord-006229-7yoilsho	3140	22	concentration	concentration	NN
cord-006229-7yoilsho	3140	23	effect	effect	NN
cord-006229-7yoilsho	3140	24	curves	curve	NNS
cord-006229-7yoilsho	3140	25	established	establish	VBN
cord-006229-7yoilsho	3140	26	for	for	IN
cord-006229-7yoilsho	3140	27	daclatasvir	daclatasvir	NNS
cord-006229-7yoilsho	3140	28	or	or	CC
cord-006229-7yoilsho	3140	29	ledipasvir	ledipasvir	NNP
cord-006229-7yoilsho	3140	30	.	.	.
cord-006229-7yoilsho	3141	1	This	this	DT
cord-006229-7yoilsho	3141	2	is	be	VBZ
cord-006229-7yoilsho	3141	3	the	the	DT
cord-006229-7yoilsho	3141	4	first	first	JJ
cord-006229-7yoilsho	3141	5	indication	indication	NN
cord-006229-7yoilsho	3141	6	of	of	IN
cord-006229-7yoilsho	3141	7	an	an	DT
cord-006229-7yoilsho	3141	8	embryotoxic	embryotoxic	JJ
cord-006229-7yoilsho	3141	9	potential	potential	NN
cord-006229-7yoilsho	3141	10	of	of	IN
cord-006229-7yoilsho	3141	11	ledipasvir	ledipasvir	NNS
cord-006229-7yoilsho	3141	12	.	.	.
cord-006229-7yoilsho	3142	1	The	the	DT
cord-006229-7yoilsho	3142	2	difference	difference	NN
cord-006229-7yoilsho	3142	3	to	to	IN
cord-006229-7yoilsho	3142	4	the	the	DT
cord-006229-7yoilsho	3142	5	results	result	NNS
cord-006229-7yoilsho	3142	6	from	from	IN
cord-006229-7yoilsho	3142	7	the	the	DT
cord-006229-7yoilsho	3142	8	routinely	routinely	RB
cord-006229-7yoilsho	3142	9	performed	perform	VBN
cord-006229-7yoilsho	3142	10	animal	animal	NN
cord-006229-7yoilsho	3142	11	experiments	experiment	NNS
cord-006229-7yoilsho	3142	12	is	be	VBZ
cord-006229-7yoilsho	3142	13	unknown	unknown	JJ
cord-006229-7yoilsho	3142	14	.	.	.
cord-006229-7yoilsho	3143	1	Possibly	possibly	RB
cord-006229-7yoilsho	3143	2	,	,	,
cord-006229-7yoilsho	3143	3	metabolic	metabolic	JJ
cord-006229-7yoilsho	3143	4	activity	activity	NN
cord-006229-7yoilsho	3143	5	in	in	IN
cord-006229-7yoilsho	3143	6	the	the	DT
cord-006229-7yoilsho	3143	7	maternal	maternal	JJ
cord-006229-7yoilsho	3143	8	organism	organism	NN
cord-006229-7yoilsho	3143	9	is	be	VBZ
cord-006229-7yoilsho	3143	10	responsible	responsible	JJ
cord-006229-7yoilsho	3143	11	for	for	IN
cord-006229-7yoilsho	3143	12	this	this	DT
cord-006229-7yoilsho	3143	13	discrepancy	discrepancy	NN
cord-006229-7yoilsho	3143	14	.	.	.
cord-006229-7yoilsho	3144	1	Dimoxystrobin	Dimoxystrobin	NNP
cord-006229-7yoilsho	3144	2	is	be	VBZ
cord-006229-7yoilsho	3144	3	a	a	DT
cord-006229-7yoilsho	3144	4	European	European	NNP
cord-006229-7yoilsho	3144	5	-	-	HYPH
cord-006229-7yoilsho	3144	6	registered	register	VBN
cord-006229-7yoilsho	3144	7	pesticidal	pesticidal	JJ
cord-006229-7yoilsho	3144	8	active	active	JJ
cord-006229-7yoilsho	3144	9	ingredient	ingredient	NN
cord-006229-7yoilsho	3144	10	.	.	.
cord-006229-7yoilsho	3145	1	Biologically	biologically	RB
cord-006229-7yoilsho	3145	2	it	-PRON-	PRP
cord-006229-7yoilsho	3145	3	is	be	VBZ
cord-006229-7yoilsho	3145	4	acting	act	VBG
cord-006229-7yoilsho	3145	5	as	as	IN
cord-006229-7yoilsho	3145	6	an	an	DT
cord-006229-7yoilsho	3145	7	inhibitor	inhibitor	NN
cord-006229-7yoilsho	3145	8	of	of	IN
cord-006229-7yoilsho	3145	9	the	the	DT
cord-006229-7yoilsho	3145	10	fungal	fungal	JJ
cord-006229-7yoilsho	3145	11	respiratory	respiratory	JJ
cord-006229-7yoilsho	3145	12	chain	chain	NN
cord-006229-7yoilsho	3145	13	.	.	.
cord-006229-7yoilsho	3146	1	For	for	IN
cord-006229-7yoilsho	3146	2	the	the	DT
cord-006229-7yoilsho	3146	3	purpose	purpose	NN
cord-006229-7yoilsho	3146	4	of	of	IN
cord-006229-7yoilsho	3146	5	European	european	JJ
cord-006229-7yoilsho	3146	6	registration	registration	NN
cord-006229-7yoilsho	3146	7	a	a	DT
cord-006229-7yoilsho	3146	8	full	full	JJ
cord-006229-7yoilsho	3146	9	set	set	NN
cord-006229-7yoilsho	3146	10	of	of	IN
cord-006229-7yoilsho	3146	11	toxicological	toxicological	JJ
cord-006229-7yoilsho	3146	12	studies	study	NNS
cord-006229-7yoilsho	3146	13	has	have	VBZ
cord-006229-7yoilsho	3146	14	been	be	VBN
cord-006229-7yoilsho	3146	15	conducted	conduct	VBN
cord-006229-7yoilsho	3146	16	with	with	IN
cord-006229-7yoilsho	3146	17	dimoxystrobin	dimoxystrobin	NNP
cord-006229-7yoilsho	3146	18	,	,	,
cord-006229-7yoilsho	3146	19	including	include	VBG
cord-006229-7yoilsho	3146	20	reproduction	reproduction	NN
cord-006229-7yoilsho	3146	21	toxicity	toxicity	NN
cord-006229-7yoilsho	3146	22	studies	study	NNS
cord-006229-7yoilsho	3146	23	(	(	-LRB-
cord-006229-7yoilsho	3146	24	according	accord	VBG
cord-006229-7yoilsho	3146	25	to	to	IN
cord-006229-7yoilsho	3146	26	the	the	DT
cord-006229-7yoilsho	3146	27	most	most	RBS
cord-006229-7yoilsho	3146	28	recent	recent	JJ
cord-006229-7yoilsho	3146	29	OECD	OECD	NNP
cord-006229-7yoilsho	3146	30	TG	TG	NNP
cord-006229-7yoilsho	3146	31	416	416	CD
cord-006229-7yoilsho	3146	32	)	)	-RRB-
cord-006229-7yoilsho	3146	33	and	and	CC
cord-006229-7yoilsho	3146	34	developmental	developmental	JJ
cord-006229-7yoilsho	3146	35	toxicity	toxicity	NN
cord-006229-7yoilsho	3146	36	studies	study	NNS
cord-006229-7yoilsho	3146	37	(	(	-LRB-
cord-006229-7yoilsho	3146	38	OECD	OECD	NNP
cord-006229-7yoilsho	3146	39	TG	TG	NNP
cord-006229-7yoilsho	3146	40	414	414	CD
cord-006229-7yoilsho	3146	41	)	)	-RRB-
cord-006229-7yoilsho	3146	42	in	in	IN
cord-006229-7yoilsho	3146	43	rats	rat	NNS
cord-006229-7yoilsho	3146	44	and	and	CC
cord-006229-7yoilsho	3146	45	rabbits	rabbit	NNS
cord-006229-7yoilsho	3146	46	.	.	.
cord-006229-7yoilsho	3147	1	Dimoxystrobin	Dimoxystrobin	NNP
cord-006229-7yoilsho	3147	2	interferes	interfere	VBZ
cord-006229-7yoilsho	3147	3	with	with	IN
cord-006229-7yoilsho	3147	4	the	the	DT
cord-006229-7yoilsho	3147	5	iron	iron	NN
cord-006229-7yoilsho	3147	6	transport	transport	NN
cord-006229-7yoilsho	3147	7	in	in	IN
cord-006229-7yoilsho	3147	8	rats	rat	NNS
cord-006229-7yoilsho	3147	9	and	and	CC
cord-006229-7yoilsho	3147	10	mice	mouse	NNS
cord-006229-7yoilsho	3147	11	.	.	.
cord-006229-7yoilsho	3148	1	This	this	DT
cord-006229-7yoilsho	3148	2	leads	lead	VBZ
cord-006229-7yoilsho	3148	3	to	to	TO
cord-006229-7yoilsho	3148	4	lower	lower	VB
cord-006229-7yoilsho	3148	5	serum	serum	NN
cord-006229-7yoilsho	3148	6	iron	iron	NN
cord-006229-7yoilsho	3148	7	levels	level	NNS
cord-006229-7yoilsho	3148	8	and	and	CC
cord-006229-7yoilsho	3148	9	anemia	anemia	NN
cord-006229-7yoilsho	3148	10	in	in	IN
cord-006229-7yoilsho	3148	11	rats	rat	NNS
cord-006229-7yoilsho	3148	12	after	after	IN
cord-006229-7yoilsho	3148	13	repeated	repeat	VBN
cord-006229-7yoilsho	3148	14	exposure	exposure	NN
cord-006229-7yoilsho	3148	15	.	.	.
cord-006229-7yoilsho	3149	1	This	this	DT
cord-006229-7yoilsho	3149	2	holds	hold	VBZ
cord-006229-7yoilsho	3149	3	true	true	JJ
cord-006229-7yoilsho	3149	4	for	for	IN
cord-006229-7yoilsho	3149	5	treated	treat	VBN
cord-006229-7yoilsho	3149	6	dams	dam	NNS
cord-006229-7yoilsho	3149	7	and	and	CC
cord-006229-7yoilsho	3149	8	offspring	offspring	NN
cord-006229-7yoilsho	3149	9	in	in	IN
cord-006229-7yoilsho	3149	10	reproduction	reproduction	NN
cord-006229-7yoilsho	3149	11	toxicity	toxicity	NN
cord-006229-7yoilsho	3149	12	studies	study	NNS
cord-006229-7yoilsho	3149	13	.	.	.
cord-006229-7yoilsho	3150	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	3150	2	,	,	,
cord-006229-7yoilsho	3150	3	offspring	offspring	NN
cord-006229-7yoilsho	3150	4	effects	effect	NNS
cord-006229-7yoilsho	3150	5	seen	see	VBN
cord-006229-7yoilsho	3150	6	at	at	IN
cord-006229-7yoilsho	3150	7	the	the	DT
cord-006229-7yoilsho	3150	8	high	high	JJ
cord-006229-7yoilsho	3150	9	dose	dose	NN
cord-006229-7yoilsho	3150	10	of	of	IN
cord-006229-7yoilsho	3150	11	the	the	DT
cord-006229-7yoilsho	3150	12	2-generation	2-generation	CD
cord-006229-7yoilsho	3150	13	toxicity	toxicity	NN
cord-006229-7yoilsho	3150	14	study	study	NN
cord-006229-7yoilsho	3150	15	were	be	VBD
cord-006229-7yoilsho	3150	16	a	a	DT
cord-006229-7yoilsho	3150	17	hypochromic	hypochromic	JJ
cord-006229-7yoilsho	3150	18	microcytic	microcytic	JJ
cord-006229-7yoilsho	3150	19	anemia	anemia	NN
cord-006229-7yoilsho	3150	20	,	,	,
cord-006229-7yoilsho	3150	21	impaired	impair	VBN
cord-006229-7yoilsho	3150	22	body	body	NN
cord-006229-7yoilsho	3150	23	weight	weight	NN
cord-006229-7yoilsho	3150	24	development	development	NN
cord-006229-7yoilsho	3150	25	,	,	,
cord-006229-7yoilsho	3150	26	which	which	WDT
cord-006229-7yoilsho	3150	27	only	only	RB
cord-006229-7yoilsho	3150	28	developed	develop	VBD
cord-006229-7yoilsho	3150	29	postnatally	postnatally	NN
cord-006229-7yoilsho	3150	30	,	,	,
cord-006229-7yoilsho	3150	31	and	and	CC
cord-006229-7yoilsho	3150	32	reversible	reversible	JJ
cord-006229-7yoilsho	3150	33	cardiomegalies	cardiomegaly	NNS
cord-006229-7yoilsho	3150	34	in	in	IN
cord-006229-7yoilsho	3150	35	some	some	DT
cord-006229-7yoilsho	3150	36	21-days	21-days	CD
cord-006229-7yoilsho	3150	37	old	old	JJ
cord-006229-7yoilsho	3150	38	pups	pup	NNS
cord-006229-7yoilsho	3150	39	.	.	.
cord-006229-7yoilsho	3151	1	For	for	IN
cord-006229-7yoilsho	3151	2	all	all	DT
cord-006229-7yoilsho	3151	3	effects	effect	NNS
cord-006229-7yoilsho	3151	4	clear	clear	JJ
cord-006229-7yoilsho	3151	5	NOAELs	noael	NNS
cord-006229-7yoilsho	3151	6	were	be	VBD
cord-006229-7yoilsho	3151	7	determined	determine	VBN
cord-006229-7yoilsho	3151	8	.	.	.
cord-006229-7yoilsho	3152	1	In	in	IN
cord-006229-7yoilsho	3152	2	the	the	DT
cord-006229-7yoilsho	3152	3	2-generation	2-generation	CD
cord-006229-7yoilsho	3152	4	toxicity	toxicity	NN
cord-006229-7yoilsho	3152	5	study	study	NN
cord-006229-7yoilsho	3152	6	no	no	DT
cord-006229-7yoilsho	3152	7	dose	dose	JJ
cord-006229-7yoilsho	3152	8	adjustment	adjustment	NN
cord-006229-7yoilsho	3152	9	during	during	IN
cord-006229-7yoilsho	3152	10	pregnancy	pregnancy	NN
cord-006229-7yoilsho	3152	11	and	and	CC
cord-006229-7yoilsho	3152	12	lactation	lactation	NN
cord-006229-7yoilsho	3152	13	was	be	VBD
cord-006229-7yoilsho	3152	14	performed	perform	VBN
cord-006229-7yoilsho	3152	15	,	,	,
cord-006229-7yoilsho	3152	16	which	which	WDT
cord-006229-7yoilsho	3152	17	resulted	result	VBD
cord-006229-7yoilsho	3152	18	in	in	IN
cord-006229-7yoilsho	3152	19	considerably	considerably	RB
cord-006229-7yoilsho	3152	20	higher	high	JJR
cord-006229-7yoilsho	3152	21	food	food	NN
cord-006229-7yoilsho	3152	22	and	and	CC
cord-006229-7yoilsho	3152	23	compound	compound	NN
cord-006229-7yoilsho	3152	24	intakes	intake	NNS
cord-006229-7yoilsho	3152	25	in	in	IN
cord-006229-7yoilsho	3152	26	dams	dam	NNS
cord-006229-7yoilsho	3152	27	and	and	CC
cord-006229-7yoilsho	3152	28	offspring	offspring	NN
cord-006229-7yoilsho	3152	29	during	during	IN
cord-006229-7yoilsho	3152	30	these	these	DT
cord-006229-7yoilsho	3152	31	lifestages	lifestage	NNS
cord-006229-7yoilsho	3152	32	.	.	.
cord-006229-7yoilsho	3153	1	As	as	IN
cord-006229-7yoilsho	3153	2	a	a	DT
cord-006229-7yoilsho	3153	3	result	result	NN
cord-006229-7yoilsho	3153	4	,	,	,
cord-006229-7yoilsho	3153	5	it	-PRON-	PRP
cord-006229-7yoilsho	3153	6	seemed	seem	VBD
cord-006229-7yoilsho	3153	7	,	,	,
cord-006229-7yoilsho	3153	8	that	that	IN
cord-006229-7yoilsho	3153	9	pups	pup	NNS
cord-006229-7yoilsho	3153	10	were	be	VBD
cord-006229-7yoilsho	3153	11	more	more	RBR
cord-006229-7yoilsho	3153	12	severely	severely	RB
cord-006229-7yoilsho	3153	13	affected	affect	VBN
cord-006229-7yoilsho	3153	14	by	by	IN
cord-006229-7yoilsho	3153	15	body	body	NN
cord-006229-7yoilsho	3153	16	weight	weight	NN
cord-006229-7yoilsho	3153	17	effects	effect	NNS
cord-006229-7yoilsho	3153	18	compared	compare	VBN
cord-006229-7yoilsho	3153	19	to	to	IN
cord-006229-7yoilsho	3153	20	the	the	DT
cord-006229-7yoilsho	3153	21	parental	parental	JJ
cord-006229-7yoilsho	3153	22	generation	generation	NN
cord-006229-7yoilsho	3153	23	.	.	.
cord-006229-7yoilsho	3154	1	By	by	IN
cord-006229-7yoilsho	3154	2	performing	perform	VBG
cord-006229-7yoilsho	3154	3	a	a	DT
cord-006229-7yoilsho	3154	4	life	life	NN
cord-006229-7yoilsho	3154	5	-	-	HYPH
cord-006229-7yoilsho	3154	6	stage	stage	NN
cord-006229-7yoilsho	3154	7	specific	specific	JJ
cord-006229-7yoilsho	3154	8	comparison	comparison	NN
cord-006229-7yoilsho	3154	9	of	of	IN
cord-006229-7yoilsho	3154	10	body	body	NN
cord-006229-7yoilsho	3154	11	weight	weight	NN
cord-006229-7yoilsho	3154	12	and	and	CC
cord-006229-7yoilsho	3154	13	substance	substance	NN
cord-006229-7yoilsho	3154	14	intakes	intake	NNS
cord-006229-7yoilsho	3154	15	,	,	,
cord-006229-7yoilsho	3154	16	as	as	RB
cord-006229-7yoilsho	3154	17	well	well	RB
cord-006229-7yoilsho	3154	18	as	as	IN
cord-006229-7yoilsho	3154	19	benchmark	benchmark	JJ
cord-006229-7yoilsho	3154	20	dose	dose	NN
cord-006229-7yoilsho	3154	21	calculations	calculation	NNS
cord-006229-7yoilsho	3154	22	(	(	-LRB-
cord-006229-7yoilsho	3154	23	BMD	BMD	NNP
cord-006229-7yoilsho	3154	24	)	)	-RRB-
cord-006229-7yoilsho	3154	25	for	for	IN
cord-006229-7yoilsho	3154	26	these	these	DT
cord-006229-7yoilsho	3154	27	parameters	parameter	NNS
cord-006229-7yoilsho	3154	28	,	,	,
cord-006229-7yoilsho	3154	29	it	-PRON-	PRP
cord-006229-7yoilsho	3154	30	could	could	MD
cord-006229-7yoilsho	3154	31	be	be	VB
cord-006229-7yoilsho	3154	32	demonstrated	demonstrate	VBN
cord-006229-7yoilsho	3154	33	that	that	IN
cord-006229-7yoilsho	3154	34	the	the	DT
cord-006229-7yoilsho	3154	35	point	point	NN
cord-006229-7yoilsho	3154	36	of	of	IN
cord-006229-7yoilsho	3154	37	departures	departure	NNS
cord-006229-7yoilsho	3154	38	(	(	-LRB-
cord-006229-7yoilsho	3154	39	PODs	pod	NNS
cord-006229-7yoilsho	3154	40	)	)	-RRB-
cord-006229-7yoilsho	3154	41	and	and	CC
cord-006229-7yoilsho	3154	42	the	the	DT
cord-006229-7yoilsho	3154	43	LOAELs	loael	NNS
cord-006229-7yoilsho	3154	44	for	for	IN
cord-006229-7yoilsho	3154	45	direct	direct	JJ
cord-006229-7yoilsho	3154	46	dimoxystrobin	dimoxystrobin	NN
cord-006229-7yoilsho	3154	47	-	-	HYPH
cord-006229-7yoilsho	3154	48	related	relate	VBN
cord-006229-7yoilsho	3154	49	effects	effect	NNS
cord-006229-7yoilsho	3154	50	were	be	VBD
cord-006229-7yoilsho	3154	51	comparable	comparable	JJ
cord-006229-7yoilsho	3154	52	for	for	IN
cord-006229-7yoilsho	3154	53	offspring	offspring	NN
cord-006229-7yoilsho	3154	54	and	and	CC
cord-006229-7yoilsho	3154	55	parents	parent	NNS
cord-006229-7yoilsho	3154	56	.	.	.
cord-006229-7yoilsho	3155	1	The	the	DT
cord-006229-7yoilsho	3155	2	heart	heart	NN
cord-006229-7yoilsho	3155	3	effects	effect	NNS
cord-006229-7yoilsho	3155	4	(	(	-LRB-
cord-006229-7yoilsho	3155	5	cardiomegaly	cardiomegaly	NN
cord-006229-7yoilsho	3155	6	)	)	-RRB-
cord-006229-7yoilsho	3155	7	,	,	,
cord-006229-7yoilsho	3155	8	which	which	WDT
cord-006229-7yoilsho	3155	9	were	be	VBD
cord-006229-7yoilsho	3155	10	reversible	reversible	JJ
cord-006229-7yoilsho	3155	11	,	,	,
cord-006229-7yoilsho	3155	12	occurred	occur	VBD
cord-006229-7yoilsho	3155	13	only	only	RB
cord-006229-7yoilsho	3155	14	after	after	IN
cord-006229-7yoilsho	3155	15	direct	direct	JJ
cord-006229-7yoilsho	3155	16	dimoxystrobinexposure	dimoxystrobinexposure	NN
cord-006229-7yoilsho	3155	17	and	and	CC
cord-006229-7yoilsho	3155	18	are	be	VBP
cord-006229-7yoilsho	3155	19	considered	consider	VBN
cord-006229-7yoilsho	3155	20	to	to	TO
cord-006229-7yoilsho	3155	21	be	be	VB
cord-006229-7yoilsho	3155	22	secondary	secondary	JJ
cord-006229-7yoilsho	3155	23	to	to	IN
cord-006229-7yoilsho	3155	24	the	the	DT
cord-006229-7yoilsho	3155	25	detected	detect	VBN
cord-006229-7yoilsho	3155	26	offspring	offspring	NN
cord-006229-7yoilsho	3155	27	anemia	anemia	NN
cord-006229-7yoilsho	3155	28	.	.	.
cord-006229-7yoilsho	3156	1	Both	both	DT
cord-006229-7yoilsho	3156	2	effects	effect	NNS
cord-006229-7yoilsho	3156	3	(	(	-LRB-
cord-006229-7yoilsho	3156	4	lower	low	JJR
cord-006229-7yoilsho	3156	5	body	body	NN
cord-006229-7yoilsho	3156	6	weights	weight	NNS
cord-006229-7yoilsho	3156	7	and	and	CC
cord-006229-7yoilsho	3156	8	offspring	offspring	NN
cord-006229-7yoilsho	3156	9	cardiomegalies	cardiomegaly	NNS
cord-006229-7yoilsho	3156	10	)	)	-RRB-
cord-006229-7yoilsho	3156	11	only	only	RB
cord-006229-7yoilsho	3156	12	occur	occur	VBP
cord-006229-7yoilsho	3156	13	postnatally	postnatally	RB
cord-006229-7yoilsho	3156	14	and	and	CC
cord-006229-7yoilsho	3156	15	are	be	VBP
cord-006229-7yoilsho	3156	16	not	not	RB
cord-006229-7yoilsho	3156	17	the	the	DT
cord-006229-7yoilsho	3156	18	consequence	consequence	NN
cord-006229-7yoilsho	3156	19	of	of	IN
cord-006229-7yoilsho	3156	20	in	in	IN
cord-006229-7yoilsho	3156	21	-	-	HYPH
cord-006229-7yoilsho	3156	22	utero	utero	NN
cord-006229-7yoilsho	3156	23	exposure	exposure	NN
cord-006229-7yoilsho	3156	24	,	,	,
cord-006229-7yoilsho	3156	25	as	as	IN
cord-006229-7yoilsho	3156	26	no	no	DT
cord-006229-7yoilsho	3156	27	respective	respective	JJ
cord-006229-7yoilsho	3156	28	effects	effect	NNS
cord-006229-7yoilsho	3156	29	at	at	IN
cord-006229-7yoilsho	3156	30	higher	high	JJR
cord-006229-7yoilsho	3156	31	doses	dose	NNS
cord-006229-7yoilsho	3156	32	in	in	IN
cord-006229-7yoilsho	3156	33	rat	rat	NN
cord-006229-7yoilsho	3156	34	prenatal	prenatal	JJ
cord-006229-7yoilsho	3156	35	toxicity	toxicity	NN
cord-006229-7yoilsho	3156	36	studies	study	NNS
cord-006229-7yoilsho	3156	37	were	be	VBD
cord-006229-7yoilsho	3156	38	seen	see	VBN
cord-006229-7yoilsho	3156	39	.	.	.
cord-006229-7yoilsho	3157	1	Two	two	CD
cord-006229-7yoilsho	3157	2	new	new	JJ
cord-006229-7yoilsho	3157	3	mechanistic	mechanistic	JJ
cord-006229-7yoilsho	3157	4	studies	study	NNS
cord-006229-7yoilsho	3157	5	(	(	-LRB-
cord-006229-7yoilsho	3157	6	1-generation	1-generation	CD
cord-006229-7yoilsho	3157	7	toxicity	toxicity	NN
cord-006229-7yoilsho	3157	8	study	study	NN
cord-006229-7yoilsho	3157	9	and	and	CC
cord-006229-7yoilsho	3157	10	a	a	DT
cord-006229-7yoilsho	3157	11	3-week	3-week	CD
cord-006229-7yoilsho	3157	12	study	study	NN
cord-006229-7yoilsho	3157	13	in	in	IN
cord-006229-7yoilsho	3157	14	young	young	JJ
cord-006229-7yoilsho	3157	15	and	and	CC
cord-006229-7yoilsho	3157	16	adult	adult	NN
cord-006229-7yoilsho	3157	17	rats	rat	NNS
cord-006229-7yoilsho	3157	18	,	,	,
cord-006229-7yoilsho	3157	19	additionally	additionally	RB
cord-006229-7yoilsho	3157	20	investigating	investigate	VBG
cord-006229-7yoilsho	3157	21	serum	serum	NN
cord-006229-7yoilsho	3157	22	iron	iron	NN
cord-006229-7yoilsho	3157	23	levels	level	NNS
cord-006229-7yoilsho	3157	24	and	and	CC
cord-006229-7yoilsho	3157	25	anemia	anemia	NN
cord-006229-7yoilsho	3157	26	)	)	-RRB-
cord-006229-7yoilsho	3157	27	confirmed	confirm	VBD
cord-006229-7yoilsho	3157	28	,	,	,
cord-006229-7yoilsho	3157	29	that	that	IN
cord-006229-7yoilsho	3157	30	pups	pup	NNS
cord-006229-7yoilsho	3157	31	and	and	CC
cord-006229-7yoilsho	3157	32	young	young	JJ
cord-006229-7yoilsho	3157	33	rats	rat	NNS
cord-006229-7yoilsho	3157	34	were	be	VBD
cord-006229-7yoilsho	3157	35	not	not	RB
cord-006229-7yoilsho	3157	36	more	more	RBR
cord-006229-7yoilsho	3157	37	sensitive	sensitive	JJ
cord-006229-7yoilsho	3157	38	than	than	IN
cord-006229-7yoilsho	3157	39	adult	adult	NN
cord-006229-7yoilsho	3157	40	animals	animal	NNS
cord-006229-7yoilsho	3157	41	to	to	TO
cord-006229-7yoilsho	3157	42	develop	develop	VB
cord-006229-7yoilsho	3157	43	anemia	anemia	NN
cord-006229-7yoilsho	3157	44	or	or	CC
cord-006229-7yoilsho	3157	45	decreased	decrease	VBD
cord-006229-7yoilsho	3157	46	serum	serum	NN
cord-006229-7yoilsho	3157	47	iron	iron	NN
cord-006229-7yoilsho	3157	48	levels	level	NNS
cord-006229-7yoilsho	3157	49	.	.	.
cord-006229-7yoilsho	3158	1	In	in	IN
cord-006229-7yoilsho	3158	2	2006	2006	CD
cord-006229-7yoilsho	3158	3	,	,	,
cord-006229-7yoilsho	3158	4	dimoxystrobin	dimoxystrobin	NNP
cord-006229-7yoilsho	3158	5	was	be	VBD
cord-006229-7yoilsho	3158	6	classified	classify	VBN
cord-006229-7yoilsho	3158	7	with	with	IN
cord-006229-7yoilsho	3158	8	R63	R63	NNP
cord-006229-7yoilsho	3158	9	(	(	-LRB-
cord-006229-7yoilsho	3158	10	possible	possible	JJ
cord-006229-7yoilsho	3158	11	risk	risk	NN
cord-006229-7yoilsho	3158	12	of	of	IN
cord-006229-7yoilsho	3158	13	harm	harm	NN
cord-006229-7yoilsho	3158	14	to	to	IN
cord-006229-7yoilsho	3158	15	the	the	DT
cord-006229-7yoilsho	3158	16	unborn	unborn	JJ
cord-006229-7yoilsho	3158	17	child	child	NN
cord-006229-7yoilsho	3158	18	)	)	-RRB-
cord-006229-7yoilsho	3158	19	by	by	IN
cord-006229-7yoilsho	3158	20	the	the	DT
cord-006229-7yoilsho	3158	21	ECB	ECB	NNP
cord-006229-7yoilsho	3158	22	,	,	,
cord-006229-7yoilsho	3158	23	which	which	WDT
cord-006229-7yoilsho	3158	24	was	be	VBD
cord-006229-7yoilsho	3158	25	the	the	DT
cord-006229-7yoilsho	3158	26	European	European	NNP
cord-006229-7yoilsho	3158	27	Authority	Authority	NNP
cord-006229-7yoilsho	3158	28	responsible	responsible	JJ
cord-006229-7yoilsho	3158	29	for	for	IN
cord-006229-7yoilsho	3158	30	classification	classification	NN
cord-006229-7yoilsho	3158	31	and	and	CC
cord-006229-7yoilsho	3158	32	labeling	labeling	NN
cord-006229-7yoilsho	3158	33	,	,	,
cord-006229-7yoilsho	3158	34	before	before	IN
cord-006229-7yoilsho	3158	35	ECHA	ECHA	NNP
cord-006229-7yoilsho	3158	36	in	in	IN
cord-006229-7yoilsho	3158	37	Helsinki	Helsinki	NNP
cord-006229-7yoilsho	3158	38	was	be	VBD
cord-006229-7yoilsho	3158	39	formed	form	VBN
cord-006229-7yoilsho	3158	40	.	.	.
cord-006229-7yoilsho	3159	1	The	the	DT
cord-006229-7yoilsho	3159	2	R63	R63	NNP
cord-006229-7yoilsho	3159	3	(	(	-LRB-
cord-006229-7yoilsho	3159	4	which	which	WDT
cord-006229-7yoilsho	3159	5	has	have	VBZ
cord-006229-7yoilsho	3159	6	been	be	VBN
cord-006229-7yoilsho	3159	7	translated	translate	VBN
cord-006229-7yoilsho	3159	8	into	into	IN
cord-006229-7yoilsho	3159	9	the	the	DT
cord-006229-7yoilsho	3159	10	GHS	GHS	NNP
cord-006229-7yoilsho	3159	11	classification	classification	NN
cord-006229-7yoilsho	3159	12	Repr	Repr	NNP
cord-006229-7yoilsho	3159	13	.	.	.
cord-006229-7yoilsho	3159	14	2	2	CD
cord-006229-7yoilsho	3159	15	,	,	,
cord-006229-7yoilsho	3159	16	H361d	H361d	NNP
cord-006229-7yoilsho	3159	17	)	)	-RRB-
cord-006229-7yoilsho	3159	18	was	be	VBD
cord-006229-7yoilsho	3159	19	based	base	VBN
cord-006229-7yoilsho	3159	20	on	on	IN
cord-006229-7yoilsho	3159	21	offspring	offspre	VBG
cord-006229-7yoilsho	3159	22	body	body	NN
cord-006229-7yoilsho	3159	23	weight	weight	NN
cord-006229-7yoilsho	3159	24	and	and	CC
cord-006229-7yoilsho	3159	25	heart	heart	NN
cord-006229-7yoilsho	3159	26	effects	effect	NNS
cord-006229-7yoilsho	3159	27	seen	see	VBN
cord-006229-7yoilsho	3159	28	in	in	IN
cord-006229-7yoilsho	3159	29	the	the	DT
cord-006229-7yoilsho	3159	30	2-generation	2-generation	CD
cord-006229-7yoilsho	3159	31	toxicity	toxicity	NN
cord-006229-7yoilsho	3159	32	study	study	NN
cord-006229-7yoilsho	3159	33	.	.	.
cord-006229-7yoilsho	3160	1	Based	base	VBN
cord-006229-7yoilsho	3160	2	on	on	IN
cord-006229-7yoilsho	3160	3	a	a	DT
cord-006229-7yoilsho	3160	4	comprehensive	comprehensive	JJ
cord-006229-7yoilsho	3160	5	re	re	NN
cord-006229-7yoilsho	3160	6	-	-	NN
cord-006229-7yoilsho	3160	7	evaluation	evaluation	NN
cord-006229-7yoilsho	3160	8	of	of	IN
cord-006229-7yoilsho	3160	9	existing	exist	VBG
cord-006229-7yoilsho	3160	10	and	and	CC
cord-006229-7yoilsho	3160	11	on	on	IN
cord-006229-7yoilsho	3160	12	new	new	JJ
cord-006229-7yoilsho	3160	13	data	datum	NNS
cord-006229-7yoilsho	3160	14	of	of	IN
cord-006229-7yoilsho	3160	15	dimoxystrobin	dimoxystrobin	NNP
cord-006229-7yoilsho	3160	16	,	,	,
cord-006229-7yoilsho	3160	17	the	the	DT
cord-006229-7yoilsho	3160	18	conclusion	conclusion	NN
cord-006229-7yoilsho	3160	19	can	can	MD
cord-006229-7yoilsho	3160	20	be	be	VB
cord-006229-7yoilsho	3160	21	drawn	draw	VBN
cord-006229-7yoilsho	3160	22	,	,	,
cord-006229-7yoilsho	3160	23	that	that	IN
cord-006229-7yoilsho	3160	24	a	a	DT
cord-006229-7yoilsho	3160	25	classification	classification	NN
cord-006229-7yoilsho	3160	26	for	for	IN
cord-006229-7yoilsho	3160	27	reproduction	reproduction	NN
cord-006229-7yoilsho	3160	28	toxicity	toxicity	NN
cord-006229-7yoilsho	3160	29	is	be	VBZ
cord-006229-7yoilsho	3160	30	scientifically	scientifically	RB
cord-006229-7yoilsho	3160	31	not	not	RB
cord-006229-7yoilsho	3160	32	justified	justified	JJ
cord-006229-7yoilsho	3160	33	and	and	CC
cord-006229-7yoilsho	3160	34	should	should	MD
cord-006229-7yoilsho	3160	35	be	be	VB
cord-006229-7yoilsho	3160	36	reconsidered	reconsider	VBN
cord-006229-7yoilsho	3160	37	.	.	.
cord-006229-7yoilsho	3161	1	Perfluorooctanesulfonic	perfluorooctanesulfonic	JJ
cord-006229-7yoilsho	3161	2	acid	acid	NN
cord-006229-7yoilsho	3161	3	(	(	-LRB-
cord-006229-7yoilsho	3161	4	PFOS	PFOS	NNP
cord-006229-7yoilsho	3161	5	)	)	-RRB-
cord-006229-7yoilsho	3161	6	and	and	CC
cord-006229-7yoilsho	3161	7	perfluorooctanoic	perfluorooctanoic	NNP
cord-006229-7yoilsho	3161	8	acid	acid	NN
cord-006229-7yoilsho	3161	9	(	(	-LRB-
cord-006229-7yoilsho	3161	10	PFOA	PFOA	NNP
cord-006229-7yoilsho	3161	11	)	)	-RRB-
cord-006229-7yoilsho	3161	12	are	be	VBP
cord-006229-7yoilsho	3161	13	perfluorinated	perfluorinate	VBN
cord-006229-7yoilsho	3161	14	substances	substance	NNS
cord-006229-7yoilsho	3161	15	(	(	-LRB-
cord-006229-7yoilsho	3161	16	PFAS	PFAS	NNP
cord-006229-7yoilsho	3161	17	)	)	-RRB-
cord-006229-7yoilsho	3161	18	which	which	WDT
cord-006229-7yoilsho	3161	19	are	be	VBP
cord-006229-7yoilsho	3161	20	used	use	VBN
cord-006229-7yoilsho	3161	21	for	for	IN
cord-006229-7yoilsho	3161	22	the	the	DT
cord-006229-7yoilsho	3161	23	fabrication	fabrication	NN
cord-006229-7yoilsho	3161	24	of	of	IN
cord-006229-7yoilsho	3161	25	surfaces	surface	NNS
cord-006229-7yoilsho	3161	26	with	with	IN
cord-006229-7yoilsho	3161	27	water	water	NN
cord-006229-7yoilsho	3161	28	-	-	HYPH
cord-006229-7yoilsho	3161	29	and	and	CC
cord-006229-7yoilsho	3161	30	dirt	dirt	NN
cord-006229-7yoilsho	3161	31	-	-	HYPH
cord-006229-7yoilsho	3161	32	repellent	repellent	NN
cord-006229-7yoilsho	3161	33	properties	property	NNS
cord-006229-7yoilsho	3161	34	.	.	.
cord-006229-7yoilsho	3162	1	Due	due	IN
cord-006229-7yoilsho	3162	2	to	to	IN
cord-006229-7yoilsho	3162	3	their	-PRON-	PRP$
cord-006229-7yoilsho	3162	4	reprotoxic	reprotoxic	JJ
cord-006229-7yoilsho	3162	5	properties	property	NNS
cord-006229-7yoilsho	3162	6	and	and	CC
cord-006229-7yoilsho	3162	7	their	-PRON-	PRP$
cord-006229-7yoilsho	3162	8	persistence	persistence	NN
cord-006229-7yoilsho	3162	9	in	in	IN
cord-006229-7yoilsho	3162	10	the	the	DT
cord-006229-7yoilsho	3162	11	environment	environment	NN
cord-006229-7yoilsho	3162	12	,	,	,
cord-006229-7yoilsho	3162	13	the	the	DT
cord-006229-7yoilsho	3162	14	use	use	NN
cord-006229-7yoilsho	3162	15	of	of	IN
cord-006229-7yoilsho	3162	16	PFOS	PFOS	NNP
cord-006229-7yoilsho	3162	17	was	be	VBD
cord-006229-7yoilsho	3162	18	restricted	restrict	VBN
cord-006229-7yoilsho	3162	19	in	in	IN
cord-006229-7yoilsho	3162	20	2009	2009	CD
cord-006229-7yoilsho	3162	21	and	and	CC
cord-006229-7yoilsho	3162	22	a	a	DT
cord-006229-7yoilsho	3162	23	restriction	restriction	NN
cord-006229-7yoilsho	3162	24	program	program	NN
cord-006229-7yoilsho	3162	25	for	for	IN
cord-006229-7yoilsho	3162	26	PFOA	PFOA	NNP
cord-006229-7yoilsho	3162	27	was	be	VBD
cord-006229-7yoilsho	3162	28	initiated	initiate	VBN
cord-006229-7yoilsho	3162	29	in	in	IN
cord-006229-7yoilsho	3162	30	2013	2013	CD
cord-006229-7yoilsho	3162	31	.	.	.
cord-006229-7yoilsho	3163	1	Therefore	therefore	RB
cord-006229-7yoilsho	3163	2	,	,	,
cord-006229-7yoilsho	3163	3	industry	industry	NN
cord-006229-7yoilsho	3163	4	switches	switch	NNS
cord-006229-7yoilsho	3163	5	to	to	IN
cord-006229-7yoilsho	3163	6	PFOA	PFOA	NNP
cord-006229-7yoilsho	3163	7	and	and	CC
cord-006229-7yoilsho	3163	8	PFOS	PFOS	NNP
cord-006229-7yoilsho	3163	9	substitutes	substitute	NNS
cord-006229-7yoilsho	3163	10	,	,	,
cord-006229-7yoilsho	3163	11	which	which	WDT
cord-006229-7yoilsho	3163	12	are	be	VBP
cord-006229-7yoilsho	3163	13	predominantly	predominantly	RB
cord-006229-7yoilsho	3163	14	PFAS	PFAS	NNP
cord-006229-7yoilsho	3163	15	with	with	IN
cord-006229-7yoilsho	3163	16	a	a	DT
cord-006229-7yoilsho	3163	17	shorter	short	JJR
cord-006229-7yoilsho	3163	18	carbon	carbon	NN
cord-006229-7yoilsho	3163	19	chain	chain	NN
cord-006229-7yoilsho	3163	20	length	length	NN
cord-006229-7yoilsho	3163	21	,	,	,
cord-006229-7yoilsho	3163	22	or	or	CC
cord-006229-7yoilsho	3163	23	structure	structure	NN
cord-006229-7yoilsho	3163	24	-	-	HYPH
cord-006229-7yoilsho	3163	25	related	relate	VBN
cord-006229-7yoilsho	3163	26	compounds	compound	NNS
cord-006229-7yoilsho	3163	27	.	.	.
cord-006229-7yoilsho	3164	1	In	in	IN
cord-006229-7yoilsho	3164	2	contrast	contrast	NN
cord-006229-7yoilsho	3164	3	to	to	IN
cord-006229-7yoilsho	3164	4	PFOA	PFOA	NNP
cord-006229-7yoilsho	3164	5	and	and	CC
cord-006229-7yoilsho	3164	6	PFOS	PFOS	NNP
cord-006229-7yoilsho	3164	7	only	only	RB
cord-006229-7yoilsho	3164	8	few	few	JJ
cord-006229-7yoilsho	3164	9	toxicological	toxicological	JJ
cord-006229-7yoilsho	3164	10	data	datum	NNS
cord-006229-7yoilsho	3164	11	are	be	VBP
cord-006229-7yoilsho	3164	12	available	available	JJ
cord-006229-7yoilsho	3164	13	for	for	IN
cord-006229-7yoilsho	3164	14	their	-PRON-	PRP$
cord-006229-7yoilsho	3164	15	substitutes	substitute	NNS
cord-006229-7yoilsho	3164	16	.	.	.
cord-006229-7yoilsho	3165	1	Aim	aim	VB
cord-006229-7yoilsho	3165	2	of	of	IN
cord-006229-7yoilsho	3165	3	this	this	DT
cord-006229-7yoilsho	3165	4	study	study	NN
cord-006229-7yoilsho	3165	5	was	be	VBD
cord-006229-7yoilsho	3165	6	to	to	TO
cord-006229-7yoilsho	3165	7	examine	examine	VB
cord-006229-7yoilsho	3165	8	endocrine	endocrine	JJ
cord-006229-7yoilsho	3165	9	effects	effect	NNS
cord-006229-7yoilsho	3165	10	of	of	IN
cord-006229-7yoilsho	3165	11	the	the	DT
cord-006229-7yoilsho	3165	12	substitutes	substitute	NNS
cord-006229-7yoilsho	3165	13	perfluorohexanesulfonic	perfluorohexanesulfonic	NNP
cord-006229-7yoilsho	3165	14	acid	acid	NN
cord-006229-7yoilsho	3165	15	(	(	-LRB-
cord-006229-7yoilsho	3165	16	PFHxS	PFHxS	NNP
cord-006229-7yoilsho	3165	17	)	)	-RRB-
cord-006229-7yoilsho	3165	18	,	,	,
cord-006229-7yoilsho	3165	19	perfluorobutanesulfonic	perfluorobutanesulfonic	NNP
cord-006229-7yoilsho	3165	20	acid	acid	NN
cord-006229-7yoilsho	3165	21	(	(	-LRB-
cord-006229-7yoilsho	3165	22	PFBS	PFBS	NNP
cord-006229-7yoilsho	3165	23	)	)	-RRB-
cord-006229-7yoilsho	3165	24	,	,	,
cord-006229-7yoilsho	3165	25	perfluorohexanoic	perfluorohexanoic	NNP
cord-006229-7yoilsho	3165	26	acid	acid	NN
cord-006229-7yoilsho	3165	27	(	(	-LRB-
cord-006229-7yoilsho	3165	28	PFHxA	PFHxA	NNP
cord-006229-7yoilsho	3165	29	)	)	-RRB-
cord-006229-7yoilsho	3165	30	,	,	,
cord-006229-7yoilsho	3165	31	perfluorobutanoic	perfluorobutanoic	JJ
cord-006229-7yoilsho	3165	32	acid	acid	NN
cord-006229-7yoilsho	3165	33	(	(	-LRB-
cord-006229-7yoilsho	3165	34	PFBA	PFBA	NNP
cord-006229-7yoilsho	3165	35	)	)	-RRB-
cord-006229-7yoilsho	3165	36	and	and	CC
cord-006229-7yoilsho	3165	37	2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propionic	2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propionic	CD
cord-006229-7yoilsho	3165	38	acid	acid	NN
cord-006229-7yoilsho	3165	39	(	(	-LRB-
cord-006229-7yoilsho	3165	40	GenX	GenX	NNP
cord-006229-7yoilsho	3165	41	)	)	-RRB-
cord-006229-7yoilsho	3165	42	in	in	IN
cord-006229-7yoilsho	3165	43	comparison	comparison	NN
cord-006229-7yoilsho	3165	44	to	to	IN
cord-006229-7yoilsho	3165	45	PFOA	PFOA	NNP
cord-006229-7yoilsho	3165	46	and	and	CC
cord-006229-7yoilsho	3165	47	PFOS	PFOS	NNP
cord-006229-7yoilsho	3165	48	.	.	.
cord-006229-7yoilsho	3166	1	A	a	DT
cord-006229-7yoilsho	3166	2	HEK-293	hek-293	JJ
cord-006229-7yoilsho	3166	3	T	t	NN
cord-006229-7yoilsho	3166	4	cell	cell	NN
cord-006229-7yoilsho	3166	5	-	-	HYPH
cord-006229-7yoilsho	3166	6	based	base	VBN
cord-006229-7yoilsho	3166	7	dual	dual	JJ
cord-006229-7yoilsho	3166	8	-	-	HYPH
cord-006229-7yoilsho	3166	9	luciferase	luciferase	JJ
cord-006229-7yoilsho	3166	10	reporter	reporter	NN
cord-006229-7yoilsho	3166	11	gene	gene	NN
cord-006229-7yoilsho	3166	12	assay	assay	NN
cord-006229-7yoilsho	3166	13	was	be	VBD
cord-006229-7yoilsho	3166	14	used	use	VBN
cord-006229-7yoilsho	3166	15	to	to	TO
cord-006229-7yoilsho	3166	16	investigate	investigate	VB
cord-006229-7yoilsho	3166	17	the	the	DT
cord-006229-7yoilsho	3166	18	potential	potential	NN
cord-006229-7yoilsho	3166	19	of	of	IN
cord-006229-7yoilsho	3166	20	these	these	DT
cord-006229-7yoilsho	3166	21	compounds	compound	NNS
cord-006229-7yoilsho	3166	22	to	to	TO
cord-006229-7yoilsho	3166	23	affect	affect	VB
cord-006229-7yoilsho	3166	24	the	the	DT
cord-006229-7yoilsho	3166	25	activity	activity	NN
cord-006229-7yoilsho	3166	26	of	of	IN
cord-006229-7yoilsho	3166	27	the	the	DT
cord-006229-7yoilsho	3166	28	human	human	JJ
cord-006229-7yoilsho	3166	29	estrogen	estrogen	NN
cord-006229-7yoilsho	3166	30	receptors	receptor	NNS
cord-006229-7yoilsho	3166	31	hERα	herα	XX
cord-006229-7yoilsho	3166	32	and	and	CC
cord-006229-7yoilsho	3166	33	hERβ	herβ	XX
cord-006229-7yoilsho	3166	34	.	.	.
cord-006229-7yoilsho	3167	1	The	the	DT
cord-006229-7yoilsho	3167	2	reporter	reporter	NN
cord-006229-7yoilsho	3167	3	gene	gene	NN
cord-006229-7yoilsho	3167	4	assay	assay	NN
cord-006229-7yoilsho	3167	5	revealed	reveal	VBD
cord-006229-7yoilsho	3167	6	no	no	DT
cord-006229-7yoilsho	3167	7	activation	activation	NN
cord-006229-7yoilsho	3167	8	of	of	IN
cord-006229-7yoilsho	3167	9	hERα	herα	NN
cord-006229-7yoilsho	3167	10	or	or	CC
cord-006229-7yoilsho	3167	11	hERβ	herβ	XX
cord-006229-7yoilsho	3167	12	by	by	IN
cord-006229-7yoilsho	3167	13	the	the	DT
cord-006229-7yoilsho	3167	14	PFAS	PFAS	NNP
cord-006229-7yoilsho	3167	15	tested	test	VBN
cord-006229-7yoilsho	3167	16	in	in	IN
cord-006229-7yoilsho	3167	17	this	this	DT
cord-006229-7yoilsho	3167	18	study	study	NN
cord-006229-7yoilsho	3167	19	.	.	.
cord-006229-7yoilsho	3168	1	To	to	TO
cord-006229-7yoilsho	3168	2	investigate	investigate	VB
cord-006229-7yoilsho	3168	3	the	the	DT
cord-006229-7yoilsho	3168	4	potential	potential	JJ
cord-006229-7yoilsho	3168	5	inhibition	inhibition	NN
cord-006229-7yoilsho	3168	6	of	of	IN
cord-006229-7yoilsho	3168	7	hERα	herα	NN
cord-006229-7yoilsho	3168	8	and	and	CC
cord-006229-7yoilsho	3168	9	hERβ	herβ	XX
cord-006229-7yoilsho	3168	10	by	by	IN
cord-006229-7yoilsho	3168	11	PFAS	PFAS	NNP
cord-006229-7yoilsho	3168	12	,	,	,
cord-006229-7yoilsho	3168	13	a	a	DT
cord-006229-7yoilsho	3168	14	coincubation	coincubation	NN
cord-006229-7yoilsho	3168	15	with	with	IN
cord-006229-7yoilsho	3168	16	the	the	DT
cord-006229-7yoilsho	3168	17	estrogen	estrogen	NN
cord-006229-7yoilsho	3168	18	receptor	receptor	NN
cord-006229-7yoilsho	3169	1	agonist	agonist	NN
cord-006229-7yoilsho	3169	2	17β	17β	NNS
cord-006229-7yoilsho	3169	3	-	-	HYPH
cord-006229-7yoilsho	3169	4	estradiol	estradiol	NNP
cord-006229-7yoilsho	3169	5	was	be	VBD
cord-006229-7yoilsho	3169	6	performed	perform	VBN
cord-006229-7yoilsho	3169	7	.	.	.
cord-006229-7yoilsho	3170	1	None	none	NN
cord-006229-7yoilsho	3170	2	of	of	IN
cord-006229-7yoilsho	3170	3	the	the	DT
cord-006229-7yoilsho	3170	4	tested	test	VBN
cord-006229-7yoilsho	3170	5	PFAS	PFAS	NNP
cord-006229-7yoilsho	3170	6	inhibited	inhibit	VBN
cord-006229-7yoilsho	3170	7	hERα	herα	XX
cord-006229-7yoilsho	3170	8	or	or	CC
cord-006229-7yoilsho	3170	9	hERβ	herβ	NN
cord-006229-7yoilsho	3170	10	activity	activity	NN
cord-006229-7yoilsho	3170	11	.	.	.
cord-006229-7yoilsho	3171	1	However	however	RB
cord-006229-7yoilsho	3171	2	,	,	,
cord-006229-7yoilsho	3171	3	in	in	IN
cord-006229-7yoilsho	3171	4	the	the	DT
cord-006229-7yoilsho	3171	5	case	case	NN
cord-006229-7yoilsho	3171	6	of	of	IN
cord-006229-7yoilsho	3171	7	hERβ	herβ	FW
cord-006229-7yoilsho	3171	8	an	an	DT
cord-006229-7yoilsho	3171	9	enhancement	enhancement	NN
cord-006229-7yoilsho	3171	10	of	of	IN
cord-006229-7yoilsho	3171	11	17β	17β	NNS
cord-006229-7yoilsho	3171	12	-	-	HYPH
cord-006229-7yoilsho	3171	13	estradiol	estradiol	NN
cord-006229-7yoilsho	3171	14	-	-	HYPH
cord-006229-7yoilsho	3171	15	stimulated	stimulate	VBN
cord-006229-7yoilsho	3171	16	activity	activity	NN
cord-006229-7yoilsho	3171	17	was	be	VBD
cord-006229-7yoilsho	3171	18	observed	observe	VBN
cord-006229-7yoilsho	3171	19	.	.	.
cord-006229-7yoilsho	3172	1	Thus	thus	RB
cord-006229-7yoilsho	3172	2	,	,	,
cord-006229-7yoilsho	3172	3	PFAS	PFAS	NNP
cord-006229-7yoilsho	3172	4	do	do	VBP
cord-006229-7yoilsho	3172	5	not	not	RB
cord-006229-7yoilsho	3172	6	directly	directly	RB
cord-006229-7yoilsho	3172	7	activate	activate	VB
cord-006229-7yoilsho	3172	8	or	or	CC
cord-006229-7yoilsho	3172	9	inhibit	inhibit	VB
cord-006229-7yoilsho	3172	10	the	the	DT
cord-006229-7yoilsho	3172	11	human	human	JJ
cord-006229-7yoilsho	3172	12	estrogen	estrogen	NN
cord-006229-7yoilsho	3172	13	receptors	receptor	NNS
cord-006229-7yoilsho	3172	14	but	but	CC
cord-006229-7yoilsho	3172	15	have	have	VBP
cord-006229-7yoilsho	3172	16	an	an	DT
cord-006229-7yoilsho	3172	17	impact	impact	NN
cord-006229-7yoilsho	3172	18	on	on	IN
cord-006229-7yoilsho	3172	19	hERβ	herβ	NN
cord-006229-7yoilsho	3172	20	activity	activity	NN
cord-006229-7yoilsho	3172	21	as	as	IN
cord-006229-7yoilsho	3172	22	they	-PRON-	PRP
cord-006229-7yoilsho	3172	23	amplify	amplify	VBP
cord-006229-7yoilsho	3172	24	the	the	DT
cord-006229-7yoilsho	3172	25	activation	activation	NN
cord-006229-7yoilsho	3172	26	mediated	mediate	VBN
cord-006229-7yoilsho	3172	27	by	by	IN
cord-006229-7yoilsho	3172	28	17β	17β	NNS
cord-006229-7yoilsho	3172	29	-	-	HYPH
cord-006229-7yoilsho	3172	30	estradiol	estradiol	NN
cord-006229-7yoilsho	3172	31	.	.	.
cord-006229-7yoilsho	3173	1	Further	further	JJ
cord-006229-7yoilsho	3173	2	studies	study	NNS
cord-006229-7yoilsho	3173	3	will	will	MD
cord-006229-7yoilsho	3173	4	be	be	VB
cord-006229-7yoilsho	3173	5	conducted	conduct	VBN
cord-006229-7yoilsho	3173	6	to	to	TO
cord-006229-7yoilsho	3173	7	examine	examine	VB
cord-006229-7yoilsho	3173	8	this	this	DT
cord-006229-7yoilsho	3173	9	synergistic	synergistic	JJ
cord-006229-7yoilsho	3173	10	effect	effect	NN
cord-006229-7yoilsho	3173	11	in	in	IN
cord-006229-7yoilsho	3173	12	more	more	JJR
cord-006229-7yoilsho	3173	13	detail	detail	NN
cord-006229-7yoilsho	3173	14	.	.	.
cord-006229-7yoilsho	3174	1	The	the	DT
cord-006229-7yoilsho	3174	2	XEER	XEER	NNP
cord-006229-7yoilsho	3174	3	-	-	HYPH
cord-006229-7yoilsho	3174	4	reporter	reporter	NN
cord-006229-7yoilsho	3174	5	cell	cell	NN
cord-006229-7yoilsho	3174	6	line	line	NN
cord-006229-7yoilsho	3174	7	:	:	:
cord-006229-7yoilsho	3174	8	a	a	DT
cord-006229-7yoilsho	3174	9	novel	novel	JJ
cord-006229-7yoilsho	3174	10	dual	dual	JJ
cord-006229-7yoilsho	3174	11	-	-	HYPH
cord-006229-7yoilsho	3174	12	color	color	NN
cord-006229-7yoilsho	3174	13	luciferase	luciferase	NN
cord-006229-7yoilsho	3174	14	reporter	reporter	NN
cord-006229-7yoilsho	3174	15	assay	assay	NN
cord-006229-7yoilsho	3174	16	for	for	IN
cord-006229-7yoilsho	3174	17	simultaneous	simultaneous	JJ
cord-006229-7yoilsho	3174	18	detection	detection	NN
cord-006229-7yoilsho	3174	19	of	of	IN
cord-006229-7yoilsho	3174	20	estrogen	estrogen	NN
cord-006229-7yoilsho	3174	21	and	and	CC
cord-006229-7yoilsho	3174	22	arylhydrocarbon	arylhydrocarbon	NNP
cord-006229-7yoilsho	3174	23	receptor	receptor	NNP
cord-006229-7yoilsho	3174	24	activation	activation	NN
cord-006229-7yoilsho	3175	1	P.	P.	NNP
cord-006229-7yoilsho	3175	2	Tarnow	Tarnow	NNP
cord-006229-7yoilsho	3175	3	Consumers	consumer	NNS
cord-006229-7yoilsho	3175	4	are	be	VBP
cord-006229-7yoilsho	3175	5	exposed	expose	VBN
cord-006229-7yoilsho	3175	6	to	to	IN
cord-006229-7yoilsho	3175	7	a	a	DT
cord-006229-7yoilsho	3175	8	multitude	multitude	NN
cord-006229-7yoilsho	3175	9	of	of	IN
cord-006229-7yoilsho	3175	10	anthropogenic	anthropogenic	JJ
cord-006229-7yoilsho	3175	11	and	and	CC
cord-006229-7yoilsho	3175	12	natural	natural	JJ
cord-006229-7yoilsho	3175	13	substances	substance	NNS
cord-006229-7yoilsho	3175	14	capable	capable	JJ
cord-006229-7yoilsho	3175	15	of	of	IN
cord-006229-7yoilsho	3175	16	activating	activate	VBG
cord-006229-7yoilsho	3175	17	or	or	CC
cord-006229-7yoilsho	3175	18	inhibiting	inhibit	VBG
cord-006229-7yoilsho	3175	19	ligand	ligand	NN
cord-006229-7yoilsho	3175	20	activated	activate	VBN
cord-006229-7yoilsho	3175	21	transcription	transcription	NN
cord-006229-7yoilsho	3175	22	factors	factor	NNS
cord-006229-7yoilsho	3175	23	,	,	,
cord-006229-7yoilsho	3175	24	respectively	respectively	RB
cord-006229-7yoilsho	3175	25	.	.	.
cord-006229-7yoilsho	3176	1	This	this	DT
cord-006229-7yoilsho	3176	2	in	in	IN
cord-006229-7yoilsho	3176	3	turn	turn	NN
cord-006229-7yoilsho	3176	4	can	can	MD
cord-006229-7yoilsho	3176	5	lead	lead	VB
cord-006229-7yoilsho	3176	6	to	to	IN
cord-006229-7yoilsho	3176	7	adverse	adverse	JJ
cord-006229-7yoilsho	3176	8	health	health	NN
cord-006229-7yoilsho	3176	9	effects	effect	NNS
cord-006229-7yoilsho	3176	10	,	,	,
cord-006229-7yoilsho	3176	11	particularly	particularly	RB
cord-006229-7yoilsho	3176	12	for	for	IN
cord-006229-7yoilsho	3176	13	substances	substance	NNS
cord-006229-7yoilsho	3176	14	acting	act	VBG
cord-006229-7yoilsho	3176	15	on	on	IN
cord-006229-7yoilsho	3176	16	signalling	signal	VBG
cord-006229-7yoilsho	3176	17	pathways	pathway	NNS
cord-006229-7yoilsho	3176	18	that	that	WDT
cord-006229-7yoilsho	3176	19	are	be	VBP
cord-006229-7yoilsho	3176	20	subject	subject	JJ
cord-006229-7yoilsho	3176	21	to	to	IN
cord-006229-7yoilsho	3176	22	regulatory	regulatory	JJ
cord-006229-7yoilsho	3176	23	crosstalk	crosstalk	NN
cord-006229-7yoilsho	3176	24	such	such	JJ
cord-006229-7yoilsho	3176	25	as	as	IN
cord-006229-7yoilsho	3176	26	xenoestrogens	xenoestrogen	NNS
cord-006229-7yoilsho	3176	27	and	and	CC
cord-006229-7yoilsho	3176	28	polycyclic	polycyclic	JJ
cord-006229-7yoilsho	3176	29	aromatic	aromatic	JJ
cord-006229-7yoilsho	3176	30	hydrocarbons	hydrocarbon	NNS
cord-006229-7yoilsho	3176	31	(	(	-LRB-
cord-006229-7yoilsho	3176	32	PAHs	pah	NNS
cord-006229-7yoilsho	3176	33	)	)	-RRB-
cord-006229-7yoilsho	3176	34	.	.	.
cord-006229-7yoilsho	3177	1	Xenoestrogens	Xenoestrogens	NNP
cord-006229-7yoilsho	3177	2	are	be	VBP
cord-006229-7yoilsho	3177	3	known	know	VBN
cord-006229-7yoilsho	3177	4	to	to	TO
cord-006229-7yoilsho	3177	5	activate	activate	VB
cord-006229-7yoilsho	3177	6	human	human	JJ
cord-006229-7yoilsho	3177	7	estrogen	estrogen	NN
cord-006229-7yoilsho	3177	8	receptors	receptor	NNS
cord-006229-7yoilsho	3177	9	(	(	-LRB-
cord-006229-7yoilsho	3177	10	ERs	er	NNS
cord-006229-7yoilsho	3177	11	)	)	-RRB-
cord-006229-7yoilsho	3177	12	,	,	,
cord-006229-7yoilsho	3177	13	whereas	whereas	IN
cord-006229-7yoilsho	3177	14	PAHs	pah	NNS
cord-006229-7yoilsho	3177	15	or	or	CC
cord-006229-7yoilsho	3177	16	dioxins	dioxin	NNS
cord-006229-7yoilsho	3177	17	act	act	VBP
cord-006229-7yoilsho	3177	18	on	on	IN
cord-006229-7yoilsho	3177	19	the	the	DT
cord-006229-7yoilsho	3177	20	arylhydrocarbon	arylhydrocarbon	NNP
cord-006229-7yoilsho	3177	21	receptor	receptor	NN
cord-006229-7yoilsho	3177	22	(	(	-LRB-
cord-006229-7yoilsho	3177	23	AHR	AHR	NNP
cord-006229-7yoilsho	3177	24	)	)	-RRB-
cord-006229-7yoilsho	3177	25	.	.	.
cord-006229-7yoilsho	3178	1	Importantly	importantly	RB
cord-006229-7yoilsho	3178	2	,	,	,
cord-006229-7yoilsho	3178	3	both	both	DT
cord-006229-7yoilsho	3178	4	receptor	receptor	NN
cord-006229-7yoilsho	3178	5	signalling	signal	VBG
cord-006229-7yoilsho	3178	6	pathways	pathway	NNS
cord-006229-7yoilsho	3178	7	are	be	VBP
cord-006229-7yoilsho	3178	8	interconnected	interconnect	VBN
cord-006229-7yoilsho	3178	9	by	by	IN
cord-006229-7yoilsho	3178	10	a	a	DT
cord-006229-7yoilsho	3178	11	complex	complex	JJ
cord-006229-7yoilsho	3178	12	crosstalk	crosstalk	NN
cord-006229-7yoilsho	3178	13	on	on	IN
cord-006229-7yoilsho	3178	14	multiple	multiple	JJ
cord-006229-7yoilsho	3178	15	levels	level	NNS
cord-006229-7yoilsho	3178	16	.	.	.
cord-006229-7yoilsho	3179	1	This	this	DT
cord-006229-7yoilsho	3179	2	ranges	range	VBZ
cord-006229-7yoilsho	3179	3	from	from	IN
cord-006229-7yoilsho	3179	4	direct	direct	JJ
cord-006229-7yoilsho	3179	5	protein	protein	NN
cord-006229-7yoilsho	3179	6	-	-	HYPH
cord-006229-7yoilsho	3179	7	protein	protein	NN
cord-006229-7yoilsho	3179	8	interactions	interaction	NNS
cord-006229-7yoilsho	3179	9	to	to	IN
cord-006229-7yoilsho	3179	10	competition	competition	NN
cord-006229-7yoilsho	3179	11	for	for	IN
cord-006229-7yoilsho	3179	12	common	common	JJ
cord-006229-7yoilsho	3179	13	co	co	NNS
cord-006229-7yoilsho	3179	14	-	-	NNS
cord-006229-7yoilsho	3179	15	factors	factor	NNS
cord-006229-7yoilsho	3179	16	.	.	.
cord-006229-7yoilsho	3180	1	However	however	RB
cord-006229-7yoilsho	3180	2	,	,	,
cord-006229-7yoilsho	3180	3	although	although	IN
cord-006229-7yoilsho	3180	4	this	this	DT
cord-006229-7yoilsho	3180	5	cross	cross	NN
cord-006229-7yoilsho	3180	6	-	-	NN
cord-006229-7yoilsho	3180	7	talk	talk	NN
cord-006229-7yoilsho	3180	8	has	have	VBZ
cord-006229-7yoilsho	3180	9	been	be	VBN
cord-006229-7yoilsho	3180	10	long	long	RB
cord-006229-7yoilsho	3180	11	known	know	VBN
cord-006229-7yoilsho	3180	12	we	-PRON-	PRP
cord-006229-7yoilsho	3180	13	still	still	RB
cord-006229-7yoilsho	3180	14	lack	lack	VBP
cord-006229-7yoilsho	3180	15	a	a	DT
cord-006229-7yoilsho	3180	16	deeper	deep	JJR
cord-006229-7yoilsho	3180	17	understanding	understanding	NN
cord-006229-7yoilsho	3180	18	of	of	IN
cord-006229-7yoilsho	3180	19	its	-PRON-	PRP$
cord-006229-7yoilsho	3180	20	molecular	molecular	JJ
cord-006229-7yoilsho	3180	21	mechanisms	mechanism	NNS
cord-006229-7yoilsho	3180	22	and	and	CC
cord-006229-7yoilsho	3180	23	physiological	physiological	JJ
cord-006229-7yoilsho	3180	24	implications	implication	NNS
cord-006229-7yoilsho	3180	25	.	.	.
cord-006229-7yoilsho	3181	1	One	one	CD
cord-006229-7yoilsho	3181	2	reason	reason	NN
cord-006229-7yoilsho	3181	3	for	for	IN
cord-006229-7yoilsho	3181	4	this	this	DT
cord-006229-7yoilsho	3181	5	is	be	VBZ
cord-006229-7yoilsho	3181	6	a	a	DT
cord-006229-7yoilsho	3181	7	lack	lack	NN
cord-006229-7yoilsho	3181	8	of	of	IN
cord-006229-7yoilsho	3181	9	tools	tool	NNS
cord-006229-7yoilsho	3181	10	to	to	TO
cord-006229-7yoilsho	3181	11	visualise	visualise	VB
cord-006229-7yoilsho	3181	12	and	and	CC
cord-006229-7yoilsho	3181	13	investigate	investigate	VB
cord-006229-7yoilsho	3181	14	receptor	receptor	NN
cord-006229-7yoilsho	3181	15	interaction	interaction	NN
cord-006229-7yoilsho	3181	16	in	in	IN
cord-006229-7yoilsho	3181	17	vivo	vivo	NNP
cord-006229-7yoilsho	3181	18	.	.	.
cord-006229-7yoilsho	3182	1	Based	base	VBN
cord-006229-7yoilsho	3182	2	on	on	IN
cord-006229-7yoilsho	3182	3	the	the	DT
cord-006229-7yoilsho	3182	4	breast	breast	NN
cord-006229-7yoilsho	3182	5	cancer	cancer	NN
cord-006229-7yoilsho	3182	6	cell	cell	NN
cord-006229-7yoilsho	3182	7	line	line	NN
cord-006229-7yoilsho	3182	8	T47D	T47D	NNP
cord-006229-7yoilsho	3182	9	we	-PRON-	PRP
cord-006229-7yoilsho	3182	10	thus	thus	RB
cord-006229-7yoilsho	3182	11	developed	develop	VBD
cord-006229-7yoilsho	3182	12	a	a	DT
cord-006229-7yoilsho	3182	13	dualcolour	dualcolour	JJ
cord-006229-7yoilsho	3182	14	reporter	reporter	NN
cord-006229-7yoilsho	3182	15	assay	assay	NN
cord-006229-7yoilsho	3182	16	which	which	WDT
cord-006229-7yoilsho	3182	17	allows	allow	VBZ
cord-006229-7yoilsho	3182	18	time	time	NN
cord-006229-7yoilsho	3182	19	-	-	HYPH
cord-006229-7yoilsho	3182	20	resolved	resolve	VBN
cord-006229-7yoilsho	3182	21	simultaneous	simultaneous	JJ
cord-006229-7yoilsho	3182	22	monitoring	monitoring	NN
cord-006229-7yoilsho	3182	23	of	of	IN
cord-006229-7yoilsho	3182	24	the	the	DT
cord-006229-7yoilsho	3182	25	activation	activation	NN
cord-006229-7yoilsho	3182	26	of	of	IN
cord-006229-7yoilsho	3182	27	ER	ER	NNP
cord-006229-7yoilsho	3182	28	and	and	CC
cord-006229-7yoilsho	3182	29	AHR	AHR	NNP
cord-006229-7yoilsho	3182	30	in	in	IN
cord-006229-7yoilsho	3182	31	living	living	NN
cord-006229-7yoilsho	3182	32	cells	cell	NNS
cord-006229-7yoilsho	3182	33	.	.	.
cord-006229-7yoilsho	3183	1	The	the	DT
cord-006229-7yoilsho	3183	2	assay	assay	NN
cord-006229-7yoilsho	3183	3	uses	use	VBZ
cord-006229-7yoilsho	3183	4	two	two	CD
cord-006229-7yoilsho	3183	5	beetle	beetle	NN
cord-006229-7yoilsho	3183	6	luciferases	luciferases	NNP
cord-006229-7yoilsho	3183	7	emitting	emit	VBG
cord-006229-7yoilsho	3183	8	luminescence	luminescence	NN
cord-006229-7yoilsho	3183	9	in	in	IN
cord-006229-7yoilsho	3183	10	the	the	DT
cord-006229-7yoilsho	3183	11	red	red	JJ
cord-006229-7yoilsho	3183	12	(	(	-LRB-
cord-006229-7yoilsho	3183	13	SLR	SLR	NNP
cord-006229-7yoilsho	3183	14	)	)	-RRB-
cord-006229-7yoilsho	3183	15	and	and	CC
cord-006229-7yoilsho	3183	16	the	the	DT
cord-006229-7yoilsho	3183	17	green	green	NN
cord-006229-7yoilsho	3183	18	(	(	-LRB-
cord-006229-7yoilsho	3183	19	ELuc	ELuc	NNP
cord-006229-7yoilsho	3183	20	)	)	-RRB-
cord-006229-7yoilsho	3183	21	spectrum	spectrum	NN
cord-006229-7yoilsho	3183	22	,	,	,
cord-006229-7yoilsho	3183	23	respectively	respectively	RB
cord-006229-7yoilsho	3183	24	.	.	.
cord-006229-7yoilsho	3184	1	While	while	IN
cord-006229-7yoilsho	3184	2	ELuc	ELuc	NNP
cord-006229-7yoilsho	3184	3	is	be	VBZ
cord-006229-7yoilsho	3184	4	expressed	express	VBN
cord-006229-7yoilsho	3184	5	under	under	IN
cord-006229-7yoilsho	3184	6	the	the	DT
cord-006229-7yoilsho	3184	7	control	control	NN
cord-006229-7yoilsho	3184	8	of	of	IN
cord-006229-7yoilsho	3184	9	a	a	DT
cord-006229-7yoilsho	3184	10	6-fold	6-fold	CD
cord-006229-7yoilsho	3184	11	repeated	repeat	VBN
cord-006229-7yoilsho	3184	12	xenobiotic	xenobiotic	JJ
cord-006229-7yoilsho	3184	13	response	response	NN
cord-006229-7yoilsho	3184	14	element	element	NN
cord-006229-7yoilsho	3184	15	(	(	-LRB-
cord-006229-7yoilsho	3184	16	XRE	XRE	NNP
cord-006229-7yoilsho	3184	17	)	)	-RRB-
cord-006229-7yoilsho	3184	18	SLR	SLR	NNP
cord-006229-7yoilsho	3184	19	is	be	VBZ
cord-006229-7yoilsho	3184	20	subject	subject	JJ
cord-006229-7yoilsho	3184	21	to	to	IN
cord-006229-7yoilsho	3184	22	transcription	transcription	NN
cord-006229-7yoilsho	3184	23	regulation	regulation	NN
cord-006229-7yoilsho	3184	24	by	by	IN
cord-006229-7yoilsho	3184	25	a	a	DT
cord-006229-7yoilsho	3184	26	6-fold	6-fold	CD
cord-006229-7yoilsho	3184	27	repeated	repeat	VBN
cord-006229-7yoilsho	3184	28	estrogen	estrogen	NN
cord-006229-7yoilsho	3184	29	response	response	NN
cord-006229-7yoilsho	3184	30	element	element	NN
cord-006229-7yoilsho	3184	31	(	(	-LRB-
cord-006229-7yoilsho	3184	32	ERE	ERE	NNP
cord-006229-7yoilsho	3184	33	)	)	-RRB-
cord-006229-7yoilsho	3184	34	.	.	.
cord-006229-7yoilsho	3185	1	Both	both	DT
cord-006229-7yoilsho	3185	2	constructs	construct	NNS
cord-006229-7yoilsho	3185	3	were	be	VBD
cord-006229-7yoilsho	3185	4	stably	stably	RB
cord-006229-7yoilsho	3185	5	transfected	transfecte	VBN
cord-006229-7yoilsho	3185	6	into	into	IN
cord-006229-7yoilsho	3185	7	T47D	T47D	NNP
cord-006229-7yoilsho	3185	8	human	human	JJ
cord-006229-7yoilsho	3185	9	breast	breast	NN
cord-006229-7yoilsho	3185	10	cancer	cancer	NN
cord-006229-7yoilsho	3185	11	cells	cell	NNS
cord-006229-7yoilsho	3185	12	,	,	,
cord-006229-7yoilsho	3185	13	which	which	WDT
cord-006229-7yoilsho	3185	14	endogenously	endogenously	RB
cord-006229-7yoilsho	3185	15	express	express	VBP
cord-006229-7yoilsho	3185	16	ERα	ERα	NNS
cord-006229-7yoilsho	3185	17	and	and	CC
cord-006229-7yoilsho	3185	18	AHR	AHR	NNP
cord-006229-7yoilsho	3185	19	and	and	CC
cord-006229-7yoilsho	3185	20	are	be	VBP
cord-006229-7yoilsho	3185	21	thus	thus	RB
cord-006229-7yoilsho	3185	22	ideally	ideally	RB
cord-006229-7yoilsho	3185	23	suited	suit	VBN
cord-006229-7yoilsho	3185	24	for	for	IN
cord-006229-7yoilsho	3185	25	monitoring	monitor	VBG
cord-006229-7yoilsho	3185	26	interactions	interaction	NNS
cord-006229-7yoilsho	3185	27	with	with	IN
cord-006229-7yoilsho	3185	28	both	both	DT
cord-006229-7yoilsho	3185	29	receptors	receptor	NNS
cord-006229-7yoilsho	3185	30	.	.	.
cord-006229-7yoilsho	3186	1	The	the	DT
cord-006229-7yoilsho	3186	2	respective	respective	JJ
cord-006229-7yoilsho	3186	3	"	"	``
cord-006229-7yoilsho	3186	4	XEER"-cell	xeer"-cell	FW
cord-006229-7yoilsho	3186	5	line	line	NN
cord-006229-7yoilsho	3186	6	has	have	VBZ
cord-006229-7yoilsho	3186	7	been	be	VBN
cord-006229-7yoilsho	3186	8	successfully	successfully	RB
cord-006229-7yoilsho	3186	9	subjected	subject	VBN
cord-006229-7yoilsho	3186	10	to	to	IN
cord-006229-7yoilsho	3186	11	proof	proof	NN
cord-006229-7yoilsho	3186	12	of	of	IN
cord-006229-7yoilsho	3186	13	principle	principle	JJ
cord-006229-7yoilsho	3186	14	studies	study	NNS
cord-006229-7yoilsho	3186	15	,	,	,
cord-006229-7yoilsho	3186	16	using	use	VBG
cord-006229-7yoilsho	3186	17	prototypical	prototypical	JJ
cord-006229-7yoilsho	3186	18	ER	er	NN
cord-006229-7yoilsho	3186	19	-	-	HYPH
cord-006229-7yoilsho	3186	20	and	and	CC
cord-006229-7yoilsho	3186	21	AHRligands	ahrligand	NNS
cord-006229-7yoilsho	3186	22	as	as	RB
cord-006229-7yoilsho	3186	23	well	well	RB
cord-006229-7yoilsho	3186	24	as	as	IN
cord-006229-7yoilsho	3186	25	various	various	JJ
cord-006229-7yoilsho	3186	26	phytochemicals	phytochemical	NNS
cord-006229-7yoilsho	3186	27	and	and	CC
cord-006229-7yoilsho	3186	28	xenobiotics	xenobiotic	NNS
cord-006229-7yoilsho	3186	29	.	.	.
cord-006229-7yoilsho	3187	1	Besides	besides	IN
cord-006229-7yoilsho	3187	2	E2	E2	NNP
cord-006229-7yoilsho	3187	3	and	and	CC
cord-006229-7yoilsho	3187	4	TCDD	TCDD	NNP
cord-006229-7yoilsho	3187	5	ligands	ligand	NNS
cord-006229-7yoilsho	3187	6	included	include	VBD
cord-006229-7yoilsho	3187	7	various	various	JJ
cord-006229-7yoilsho	3187	8	PAHs	pah	NNS
cord-006229-7yoilsho	3187	9	,	,	,
cord-006229-7yoilsho	3187	10	polychlorinated	polychlorinated	JJ
cord-006229-7yoilsho	3187	11	biphenyls	biphenyls	NN
cord-006229-7yoilsho	3187	12	,	,	,
cord-006229-7yoilsho	3187	13	alpha	alpha	NN
cord-006229-7yoilsho	3187	14	-	-	:
cord-006229-7yoilsho	3187	15	and	and	CC
cord-006229-7yoilsho	3187	16	betanaphthoflavone	betanaphthoflavone	NN
cord-006229-7yoilsho	3187	17	,	,	,
cord-006229-7yoilsho	3187	18	cosmetic	cosmetic	JJ
cord-006229-7yoilsho	3187	19	ingredients	ingredient	NNS
cord-006229-7yoilsho	3187	20	(	(	-LRB-
cord-006229-7yoilsho	3187	21	butylparaben	butylparaben	RB
cord-006229-7yoilsho	3187	22	,	,	,
cord-006229-7yoilsho	3187	23	benzophenone-2	benzophenone-2	NNP
cord-006229-7yoilsho	3187	24	and	and	CC
cord-006229-7yoilsho	3187	25	4-MBC	4-mbc	CD
cord-006229-7yoilsho	3187	26	)	)	-RRB-
cord-006229-7yoilsho	3187	27	,	,	,
cord-006229-7yoilsho	3187	28	bisphenol	bisphenol	NNP
cord-006229-7yoilsho	3187	29	A	A	NNP
cord-006229-7yoilsho	3187	30	,	,	,
cord-006229-7yoilsho	3187	31	genistein	genistein	NN
cord-006229-7yoilsho	3187	32	,	,	,
cord-006229-7yoilsho	3187	33	resveratrol	resveratrol	NN
cord-006229-7yoilsho	3187	34	,	,	,
cord-006229-7yoilsho	3187	35	diindoylmethane	diindoylmethane	NNP
cord-006229-7yoilsho	3187	36	as	as	RB
cord-006229-7yoilsho	3187	37	well	well	RB
cord-006229-7yoilsho	3187	38	as	as	IN
cord-006229-7yoilsho	3187	39	pharmacological	pharmacological	JJ
cord-006229-7yoilsho	3187	40	antagonists	antagonist	NNS
cord-006229-7yoilsho	3187	41	of	of	IN
cord-006229-7yoilsho	3187	42	both	both	DT
cord-006229-7yoilsho	3187	43	receptors	receptor	NNS
cord-006229-7yoilsho	3187	44	.	.	.
cord-006229-7yoilsho	3188	1	Asian	asian	JJ
cord-006229-7yoilsho	3188	2	women	woman	NNS
cord-006229-7yoilsho	3188	3	consuming	consume	VBG
cord-006229-7yoilsho	3188	4	soy	soy	NN
cord-006229-7yoilsho	3188	5	rich	rich	JJ
cord-006229-7yoilsho	3188	6	food	food	NN
cord-006229-7yoilsho	3188	7	throughout	throughout	IN
cord-006229-7yoilsho	3188	8	life	life	NN
cord-006229-7yoilsho	3188	9	possess	possess	VBP
cord-006229-7yoilsho	3188	10	lower	low	JJR
cord-006229-7yoilsho	3188	11	levels	level	NNS
cord-006229-7yoilsho	3188	12	of	of	IN
cord-006229-7yoilsho	3188	13	17betaestradiol	17betaestradiol	CD
cord-006229-7yoilsho	3188	14	(	(	-LRB-
cord-006229-7yoilsho	3188	15	E2	E2	NNP
cord-006229-7yoilsho	3188	16	)	)	-RRB-
cord-006229-7yoilsho	3188	17	in	in	IN
cord-006229-7yoilsho	3188	18	plasma	plasma	NN
cord-006229-7yoilsho	3188	19	(	(	-LRB-
cord-006229-7yoilsho	3188	20	PL	pl	NN
cord-006229-7yoilsho	3188	21	)	)	-RRB-
cord-006229-7yoilsho	3188	22	than	than	IN
cord-006229-7yoilsho	3188	23	Western	western	JJ
cord-006229-7yoilsho	3188	24	women	woman	NNS
cord-006229-7yoilsho	3188	25	,	,	,
cord-006229-7yoilsho	3188	26	whose	whose	WP$
cord-006229-7yoilsho	3188	27	diet	diet	NN
cord-006229-7yoilsho	3188	28	is	be	VBZ
cord-006229-7yoilsho	3188	29	characterized	characterize	VBN
cord-006229-7yoilsho	3188	30	by	by	IN
cord-006229-7yoilsho	3188	31	less	less	JJR
cord-006229-7yoilsho	3188	32	soy	soy	NN
cord-006229-7yoilsho	3188	33	consumption	consumption	NN
cord-006229-7yoilsho	3188	34	during	during	IN
cord-006229-7yoilsho	3188	35	early	early	JJ
cord-006229-7yoilsho	3188	36	life	life	NN
cord-006229-7yoilsho	3188	37	and	and	CC
cord-006229-7yoilsho	3188	38	possible	possible	JJ
cord-006229-7yoilsho	3188	39	intake	intake	NN
cord-006229-7yoilsho	3188	40	of	of	IN
cord-006229-7yoilsho	3188	41	soy	soy	NN
cord-006229-7yoilsho	3188	42	based	base	VBN
cord-006229-7yoilsho	3188	43	dietary	dietary	JJ
cord-006229-7yoilsho	3188	44	supplements	supplement	NNS
cord-006229-7yoilsho	3188	45	during	during	IN
cord-006229-7yoilsho	3188	46	adulthood	adulthood	NN
cord-006229-7yoilsho	3188	47	.	.	.
cord-006229-7yoilsho	3189	1	However	however	RB
cord-006229-7yoilsho	3189	2	,	,	,
cord-006229-7yoilsho	3189	3	the	the	DT
cord-006229-7yoilsho	3189	4	impact	impact	NN
cord-006229-7yoilsho	3189	5	of	of	IN
cord-006229-7yoilsho	3189	6	these	these	DT
cord-006229-7yoilsho	3189	7	soy	soy	NN
cord-006229-7yoilsho	3189	8	exposure	exposure	NN
cord-006229-7yoilsho	3189	9	scenarios	scenario	NNS
cord-006229-7yoilsho	3189	10	on	on	IN
cord-006229-7yoilsho	3189	11	estrogen	estrogen	NN
cord-006229-7yoilsho	3189	12	(	(	-LRB-
cord-006229-7yoilsho	3189	13	biotrans)formation	biotrans)formation	NNP
cord-006229-7yoilsho	3189	14	and	and	CC
cord-006229-7yoilsho	3189	15	the	the	DT
cord-006229-7yoilsho	3189	16	consequence	consequence	NN
cord-006229-7yoilsho	3189	17	thereof	thereof	RB
cord-006229-7yoilsho	3189	18	in	in	IN
cord-006229-7yoilsho	3189	19	female	female	JJ
cord-006229-7yoilsho	3189	20	mammary	mammary	JJ
cord-006229-7yoilsho	3189	21	glands	gland	NNS
cord-006229-7yoilsho	3189	22	(	(	-LRB-
cord-006229-7yoilsho	3189	23	MG	MG	NNP
cord-006229-7yoilsho	3189	24	)	)	-RRB-
cord-006229-7yoilsho	3189	25	has	have	VBZ
cord-006229-7yoilsho	3189	26	not	not	RB
cord-006229-7yoilsho	3189	27	been	be	VBN
cord-006229-7yoilsho	3189	28	investigated	investigate	VBN
cord-006229-7yoilsho	3189	29	yet	yet	RB
cord-006229-7yoilsho	3189	30	.	.	.
cord-006229-7yoilsho	3190	1	Thus	thus	RB
cord-006229-7yoilsho	3190	2	,	,	,
cord-006229-7yoilsho	3190	3	female	female	JJ
cord-006229-7yoilsho	3190	4	August	August	NNP
cord-006229-7yoilsho	3190	5	Copenhagen	Copenhagen	NNP
cord-006229-7yoilsho	3190	6	Irish	irish	JJ
cord-006229-7yoilsho	3190	7	rats	rat	NNS
cord-006229-7yoilsho	3190	8	were	be	VBD
cord-006229-7yoilsho	3190	9	fed	feed	VBN
cord-006229-7yoilsho	3190	10	either	either	CC
cord-006229-7yoilsho	3190	11	isoflavone	isoflavone	NN
cord-006229-7yoilsho	3190	12	(	(	-LRB-
cord-006229-7yoilsho	3191	1	IF	if	IN
cord-006229-7yoilsho	3191	2	)	)	-RRB-
cord-006229-7yoilsho	3191	3	depleted	deplete	VBN
cord-006229-7yoilsho	3191	4	diet	diet	NN
cord-006229-7yoilsho	3191	5	(	(	-LRB-
cord-006229-7yoilsho	3191	6	IDD	IDD	NNP
cord-006229-7yoilsho	3191	7	,	,	,
cord-006229-7yoilsho	3191	8	Western	western	JJ
cord-006229-7yoilsho	3191	9	exposure	exposure	NN
cord-006229-7yoilsho	3191	10	scenario	scenario	NN
cord-006229-7yoilsho	3191	11	without	without	IN
cord-006229-7yoilsho	3191	12	IF	if	IN
cord-006229-7yoilsho	3191	13	supplement	supplement	NN
cord-006229-7yoilsho	3191	14	)	)	-RRB-
cord-006229-7yoilsho	3191	15	or	or	CC
cord-006229-7yoilsho	3191	16	IF	if	IN
cord-006229-7yoilsho	3191	17	rich	rich	JJ
cord-006229-7yoilsho	3191	18	diet	diet	NN
cord-006229-7yoilsho	3191	19	(	(	-LRB-
cord-006229-7yoilsho	3191	20	IRD	IRD	NNP
cord-006229-7yoilsho	3191	21	,	,	,
cord-006229-7yoilsho	3191	22	Asian	asian	JJ
cord-006229-7yoilsho	3191	23	exposure	exposure	NN
cord-006229-7yoilsho	3191	24	scenario	scenario	NN
cord-006229-7yoilsho	3191	25	)	)	-RRB-
cord-006229-7yoilsho	3191	26	until	until	IN
cord-006229-7yoilsho	3191	27	the	the	DT
cord-006229-7yoilsho	3191	28	end	end	NN
cord-006229-7yoilsho	3191	29	of	of	IN
cord-006229-7yoilsho	3191	30	the	the	DT
cord-006229-7yoilsho	3191	31	study	study	NN
cord-006229-7yoilsho	3191	32	at	at	IN
cord-006229-7yoilsho	3191	33	postnatal	postnatal	JJ
cord-006229-7yoilsho	3191	34	day	day	NN
cord-006229-7yoilsho	3191	35	(	(	-LRB-
cord-006229-7yoilsho	3191	36	PND	PND	NNP
cord-006229-7yoilsho	3191	37	)	)	-RRB-
cord-006229-7yoilsho	3191	38	81	81	CD
cord-006229-7yoilsho	3191	39	.	.	.
cord-006229-7yoilsho	3192	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	3192	2	,	,	,
cord-006229-7yoilsho	3192	3	rats	rat	NNS
cord-006229-7yoilsho	3192	4	fed	feed	VBD
cord-006229-7yoilsho	3192	5	IDD	IDD	NNP
cord-006229-7yoilsho	3192	6	until	until	IN
cord-006229-7yoilsho	3192	7	PND74	PND74	NNP
cord-006229-7yoilsho	3192	8	were	be	VBD
cord-006229-7yoilsho	3192	9	fed	feed	VBN
cord-006229-7yoilsho	3192	10	IRD	IRD	NNP
cord-006229-7yoilsho	3192	11	for	for	IN
cord-006229-7yoilsho	3192	12	7	7	CD
cord-006229-7yoilsho	3192	13	days	day	NNS
cord-006229-7yoilsho	3192	14	(	(	-LRB-
cord-006229-7yoilsho	3192	15	IDD+IRD	idd+ird	NN
cord-006229-7yoilsho	3192	16	,	,	,
cord-006229-7yoilsho	3192	17	Western	western	JJ
cord-006229-7yoilsho	3192	18	dietary	dietary	JJ
cord-006229-7yoilsho	3192	19	exposure	exposure	NN
cord-006229-7yoilsho	3192	20	scenario	scenario	NN
cord-006229-7yoilsho	3192	21	with	with	IN
cord-006229-7yoilsho	3192	22	IF	if	NN
cord-006229-7yoilsho	3192	23	supplement	supplement	NN
cord-006229-7yoilsho	3192	24	)	)	-RRB-
cord-006229-7yoilsho	3192	25	.	.	.
cord-006229-7yoilsho	3193	1	Estrous	Estrous	NNP
cord-006229-7yoilsho	3193	2	was	be	VBD
cord-006229-7yoilsho	3193	3	determined	determine	VBN
cord-006229-7yoilsho	3193	4	histologically	histologically	RB
cord-006229-7yoilsho	3193	5	.	.	.
cord-006229-7yoilsho	3194	1	Levels	level	NNS
cord-006229-7yoilsho	3194	2	of	of	IN
cord-006229-7yoilsho	3194	3	transcripts	transcript	NNS
cord-006229-7yoilsho	3194	4	were	be	VBD
cord-006229-7yoilsho	3194	5	determined	determine	VBN
cord-006229-7yoilsho	3194	6	by	by	IN
cord-006229-7yoilsho	3194	7	qPCR	qPCR	NNP
cord-006229-7yoilsho	3194	8	and	and	CC
cord-006229-7yoilsho	3194	9	E2	E2	NNP
cord-006229-7yoilsho	3194	10	and	and	CC
cord-006229-7yoilsho	3194	11	estrone	estrone	NN
cord-006229-7yoilsho	3194	12	(	(	-LRB-
cord-006229-7yoilsho	3194	13	E1	E1	NNP
cord-006229-7yoilsho	3194	14	)	)	-RRB-
cord-006229-7yoilsho	3194	15	in	in	IN
cord-006229-7yoilsho	3194	16	PL	PL	NNP
cord-006229-7yoilsho	3194	17	and	and	CC
cord-006229-7yoilsho	3194	18	MG	MG	NNP
cord-006229-7yoilsho	3194	19	were	be	VBD
cord-006229-7yoilsho	3194	20	quantified	quantify	VBN
cord-006229-7yoilsho	3194	21	by	by	IN
cord-006229-7yoilsho	3194	22	GC	GC	NNP
cord-006229-7yoilsho	3194	23	-	-	HYPH
cord-006229-7yoilsho	3194	24	MS	MS	NNP
cord-006229-7yoilsho	3194	25	/	/	SYM
cord-006229-7yoilsho	3194	26	MS	MS	NNP
cord-006229-7yoilsho	3194	27	.	.	.
cord-006229-7yoilsho	3195	1	Statistical	statistical	JJ
cord-006229-7yoilsho	3195	2	analyses	analysis	NNS
cord-006229-7yoilsho	3195	3	of	of	IN
cord-006229-7yoilsho	3195	4	estrogens	estrogen	NNS
cord-006229-7yoilsho	3195	5	were	be	VBD
cord-006229-7yoilsho	3195	6	performed	perform	VBN
cord-006229-7yoilsho	3195	7	by	by	IN
cord-006229-7yoilsho	3195	8	Kruskal	Kruskal	NNP
cord-006229-7yoilsho	3195	9	Wallis	Wallis	NNP
cord-006229-7yoilsho	3195	10	and	and	CC
cord-006229-7yoilsho	3195	11	unpaired	unpaired	JJ
cord-006229-7yoilsho	3195	12	Wilcoxon	Wilcoxon	NNP
cord-006229-7yoilsho	3195	13	tests	test	NNS
cord-006229-7yoilsho	3195	14	and	and	CC
cord-006229-7yoilsho	3195	15	of	of	IN
cord-006229-7yoilsho	3195	16	transcript	transcript	NN
cord-006229-7yoilsho	3195	17	levels	level	NNS
cord-006229-7yoilsho	3195	18	by	by	IN
cord-006229-7yoilsho	3195	19	linear	linear	JJ
cord-006229-7yoilsho	3195	20	regression	regression	NN
cord-006229-7yoilsho	3195	21	models	model	NNS
cord-006229-7yoilsho	3195	22	considering	consider	VBG
cord-006229-7yoilsho	3195	23	the	the	DT
cord-006229-7yoilsho	3195	24	explanatory	explanatory	JJ
cord-006229-7yoilsho	3195	25	variables	variable	NNS
cord-006229-7yoilsho	3195	26	tissue	tissue	NN
cord-006229-7yoilsho	3195	27	levels	level	NNS
cord-006229-7yoilsho	3195	28	of	of	IN
cord-006229-7yoilsho	3195	29	E2	E2	NNP
cord-006229-7yoilsho	3195	30	and	and	CC
cord-006229-7yoilsho	3195	31	diet	diet	NNP
cord-006229-7yoilsho	3195	32	(	(	-LRB-
cord-006229-7yoilsho	3195	33	IDD	IDD	NNP
cord-006229-7yoilsho	3195	34	vs	vs	IN
cord-006229-7yoilsho	3195	35	IRD	IRD	NNP
cord-006229-7yoilsho	3195	36	and	and	CC
cord-006229-7yoilsho	3195	37	IDD	IDD	NNP
cord-006229-7yoilsho	3195	38	vs	vs	IN
cord-006229-7yoilsho	3195	39	IDD+IRD	IDD+IRD	NNP
cord-006229-7yoilsho	3195	40	)	)	-RRB-
cord-006229-7yoilsho	3195	41	.	.	.
cord-006229-7yoilsho	3196	1	E2	E2	NNP
cord-006229-7yoilsho	3196	2	levels	level	NNS
cord-006229-7yoilsho	3196	3	in	in	IN
cord-006229-7yoilsho	3196	4	PL	PL	NNP
cord-006229-7yoilsho	3196	5	and	and	CC
cord-006229-7yoilsho	3196	6	MG	MG	NNP
cord-006229-7yoilsho	3196	7	did	do	VBD
cord-006229-7yoilsho	3196	8	not	not	RB
cord-006229-7yoilsho	3196	9	coincide	coincide	VB
cord-006229-7yoilsho	3196	10	with	with	IN
cord-006229-7yoilsho	3196	11	those	those	DT
cord-006229-7yoilsho	3196	12	predicted	predict	VBN
cord-006229-7yoilsho	3196	13	by	by	IN
cord-006229-7yoilsho	3196	14	estrous	estrous	NN
cord-006229-7yoilsho	3196	15	.	.	.
cord-006229-7yoilsho	3197	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	3197	2	,	,	,
cord-006229-7yoilsho	3197	3	median	median	JJ
cord-006229-7yoilsho	3197	4	levels	level	NNS
cord-006229-7yoilsho	3197	5	of	of	IN
cord-006229-7yoilsho	3197	6	E1	e1	NN
cord-006229-7yoilsho	3197	7	and	and	CC
cord-006229-7yoilsho	3197	8	ratios	ratio	NNS
cord-006229-7yoilsho	3197	9	E2	E2	NNP
cord-006229-7yoilsho	3197	10	/	/	SYM
cord-006229-7yoilsho	3197	11	E1	e1	NN
cord-006229-7yoilsho	3197	12	in	in	IN
cord-006229-7yoilsho	3197	13	MG	MG	NNP
cord-006229-7yoilsho	3197	14	and	and	CC
cord-006229-7yoilsho	3197	15	ratio	ratio	NN
cord-006229-7yoilsho	3197	16	of	of	IN
cord-006229-7yoilsho	3197	17	E2	E2	NNP
cord-006229-7yoilsho	3197	18	levels	level	NNS
cord-006229-7yoilsho	3197	19	in	in	IN
cord-006229-7yoilsho	3197	20	PL	PL	NNP
cord-006229-7yoilsho	3197	21	/	/	SYM
cord-006229-7yoilsho	3197	22	MG	MG	NNP
cord-006229-7yoilsho	3197	23	were	be	VBD
cord-006229-7yoilsho	3197	24	not	not	RB
cord-006229-7yoilsho	3197	25	affected	affect	VBN
cord-006229-7yoilsho	3197	26	by	by	IN
cord-006229-7yoilsho	3197	27	diet	diet	NN
cord-006229-7yoilsho	3197	28	.	.	.
cord-006229-7yoilsho	3198	1	In	in	IN
cord-006229-7yoilsho	3198	2	contrast	contrast	NN
cord-006229-7yoilsho	3198	3	,	,	,
cord-006229-7yoilsho	3198	4	diet	diet	NN
cord-006229-7yoilsho	3198	5	tended	tend	VBD
cord-006229-7yoilsho	3198	6	to	to	TO
cord-006229-7yoilsho	3198	7	affect	affect	VB
cord-006229-7yoilsho	3198	8	E2	E2	NNP
cord-006229-7yoilsho	3198	9	concentrations	concentration	NNS
cord-006229-7yoilsho	3198	10	in	in	IN
cord-006229-7yoilsho	3198	11	PL	PL	NNP
cord-006229-7yoilsho	3198	12	(	(	-LRB-
cord-006229-7yoilsho	3198	13	p=0.1211	p=0.1211	NNS
cord-006229-7yoilsho	3198	14	)	)	-RRB-
cord-006229-7yoilsho	3198	15	due	due	IN
cord-006229-7yoilsho	3198	16	to	to	IN
cord-006229-7yoilsho	3198	17	an	an	DT
cord-006229-7yoilsho	3198	18	increase	increase	NN
cord-006229-7yoilsho	3198	19	in	in	IN
cord-006229-7yoilsho	3198	20	the	the	DT
cord-006229-7yoilsho	3198	21	IRD	IRD	NNP
cord-006229-7yoilsho	3198	22	group	group	NN
cord-006229-7yoilsho	3198	23	(	(	-LRB-
cord-006229-7yoilsho	3198	24	p=0.0056	p=0.0056	NNP
cord-006229-7yoilsho	3198	25	)	)	-RRB-
cord-006229-7yoilsho	3198	26	whereas	whereas	IN
cord-006229-7yoilsho	3198	27	E2	E2	NNP
cord-006229-7yoilsho	3198	28	levels	level	NNS
cord-006229-7yoilsho	3198	29	in	in	IN
cord-006229-7yoilsho	3198	30	the	the	DT
cord-006229-7yoilsho	3198	31	IDD+IRD	IDD+IRD	NNP
cord-006229-7yoilsho	3198	32	group	group	NN
cord-006229-7yoilsho	3198	33	only	only	RB
cord-006229-7yoilsho	3198	34	tended	tend	VBD
cord-006229-7yoilsho	3198	35	to	to	TO
cord-006229-7yoilsho	3198	36	be	be	VB
cord-006229-7yoilsho	3198	37	elevated	elevate	VBN
cord-006229-7yoilsho	3198	38	(	(	-LRB-
cord-006229-7yoilsho	3198	39	p=0.0788	p=0.0788	NNS
cord-006229-7yoilsho	3198	40	)	)	-RRB-
cord-006229-7yoilsho	3198	41	.	.	.
cord-006229-7yoilsho	3199	1	In	in	IN
cord-006229-7yoilsho	3199	2	MG	MG	NNP
cord-006229-7yoilsho	3199	3	,	,	,
cord-006229-7yoilsho	3199	4	IRD	IRD	NNP
cord-006229-7yoilsho	3199	5	and	and	CC
cord-006229-7yoilsho	3199	6	IDD+IRD	IDD+IRD	NNP
cord-006229-7yoilsho	3199	7	increased	increase	VBD
cord-006229-7yoilsho	3199	8	E2	E2	NNP
cord-006229-7yoilsho	3199	9	levels	level	NNS
cord-006229-7yoilsho	3199	10	only	only	RB
cord-006229-7yoilsho	3199	11	weakly	weakly	RB
cord-006229-7yoilsho	3199	12	(	(	-LRB-
cord-006229-7yoilsho	3199	13	p=0.0788	p=0.0788	VBZ
cord-006229-7yoilsho	3199	14	each	each	DT
cord-006229-7yoilsho	3199	15	)	)	-RRB-
cord-006229-7yoilsho	3199	16	.	.	.
cord-006229-7yoilsho	3200	1	Likewise	likewise	RB
cord-006229-7yoilsho	3200	2	,	,	,
cord-006229-7yoilsho	3200	3	besides	besides	IN
cord-006229-7yoilsho	3200	4	significant	significant	JJ
cord-006229-7yoilsho	3200	5	changes	change	NNS
cord-006229-7yoilsho	3200	6	in	in	IN
cord-006229-7yoilsho	3200	7	transcript	transcript	NN
cord-006229-7yoilsho	3200	8	levels	level	NNS
cord-006229-7yoilsho	3200	9	of	of	IN
cord-006229-7yoilsho	3200	10	Cyp1a1	Cyp1a1	NNP
cord-006229-7yoilsho	3200	11	and	and	CC
cord-006229-7yoilsho	3200	12	1a2	1a2	CD
cord-006229-7yoilsho	3200	13	,	,	,
cord-006229-7yoilsho	3200	14	putatively	putatively	RB
cord-006229-7yoilsho	3200	15	decreasing	decrease	VBG
cord-006229-7yoilsho	3200	16	oxidation	oxidation	NN
cord-006229-7yoilsho	3200	17	of	of	IN
cord-006229-7yoilsho	3200	18	E2	E2	NNP
cord-006229-7yoilsho	3200	19	to	to	IN
cord-006229-7yoilsho	3200	20	catechols	catechol	NNS
cord-006229-7yoilsho	3200	21	,	,	,
cord-006229-7yoilsho	3200	22	in	in	IN
cord-006229-7yoilsho	3200	23	the	the	DT
cord-006229-7yoilsho	3200	24	IDD+IRD	IDD+IRD	NNP
cord-006229-7yoilsho	3200	25	group	group	NN
cord-006229-7yoilsho	3200	26	and	and	CC
cord-006229-7yoilsho	3200	27	(	(	-LRB-
cord-006229-7yoilsho	3200	28	not	not	RB
cord-006229-7yoilsho	3200	29	significantly	significantly	RB
cord-006229-7yoilsho	3200	30	)	)	-RRB-
cord-006229-7yoilsho	3200	31	also	also	RB
cord-006229-7yoilsho	3200	32	in	in	IN
cord-006229-7yoilsho	3200	33	the	the	DT
cord-006229-7yoilsho	3200	34	IRD	IRD	NNP
cord-006229-7yoilsho	3200	35	group	group	NN
cord-006229-7yoilsho	3200	36	,	,	,
cord-006229-7yoilsho	3200	37	no	no	DT
cord-006229-7yoilsho	3200	38	changes	change	NNS
cord-006229-7yoilsho	3200	39	in	in	IN
cord-006229-7yoilsho	3200	40	transcript	transcript	NN
cord-006229-7yoilsho	3200	41	levels	level	NNS
cord-006229-7yoilsho	3200	42	putatively	putatively	RB
cord-006229-7yoilsho	3200	43	affecting	affect	VBG
cord-006229-7yoilsho	3200	44	E2	E2	NNP
cord-006229-7yoilsho	3200	45	levels	level	NNS
cord-006229-7yoilsho	3200	46	were	be	VBD
cord-006229-7yoilsho	3200	47	observed	observe	VBN
cord-006229-7yoilsho	3200	48	.	.	.
cord-006229-7yoilsho	3201	1	Moreover	moreover	RB
cord-006229-7yoilsho	3201	2	,	,	,
cord-006229-7yoilsho	3201	3	no	no	DT
cord-006229-7yoilsho	3201	4	decrease	decrease	NN
cord-006229-7yoilsho	3201	5	in	in	IN
cord-006229-7yoilsho	3201	6	levels	level	NNS
cord-006229-7yoilsho	3201	7	of	of	IN
cord-006229-7yoilsho	3201	8	transcripts	transcript	NNS
cord-006229-7yoilsho	3201	9	indicative	indicative	JJ
cord-006229-7yoilsho	3201	10	for	for	IN
cord-006229-7yoilsho	3201	11	cellular	cellular	JJ
cord-006229-7yoilsho	3201	12	(	(	-LRB-
cord-006229-7yoilsho	3201	13	oxidative	oxidative	JJ
cord-006229-7yoilsho	3201	14	)	)	-RRB-
cord-006229-7yoilsho	3201	15	stress	stress	NN
cord-006229-7yoilsho	3201	16	(	(	-LRB-
cord-006229-7yoilsho	3202	1	Gclc	Gclc	NNP
cord-006229-7yoilsho	3202	2	,	,	,
cord-006229-7yoilsho	3202	3	Tp53	Tp53	NNP
cord-006229-7yoilsho	3202	4	,	,	,
cord-006229-7yoilsho	3202	5	Mt1a	Mt1a	NNP
cord-006229-7yoilsho	3202	6	)	)	-RRB-
cord-006229-7yoilsho	3202	7	was	be	VBD
cord-006229-7yoilsho	3202	8	observed	observe	VBN
cord-006229-7yoilsho	3202	9	in	in	IN
cord-006229-7yoilsho	3202	10	the	the	DT
cord-006229-7yoilsho	3202	11	IDD+IRD	IDD+IRD	NNP
cord-006229-7yoilsho	3202	12	group	group	NN
cord-006229-7yoilsho	3202	13	.	.	.
cord-006229-7yoilsho	3203	1	E2	E2	NNP
cord-006229-7yoilsho	3203	2	MG	MG	NNP
cord-006229-7yoilsho	3203	3	levels	level	NNS
cord-006229-7yoilsho	3203	4	were	be	VBD
cord-006229-7yoilsho	3203	5	significantly	significantly	RB
cord-006229-7yoilsho	3203	6	associated	associate	VBN
cord-006229-7yoilsho	3203	7	with	with	IN
cord-006229-7yoilsho	3203	8	an	an	DT
cord-006229-7yoilsho	3203	9	increase	increase	NN
cord-006229-7yoilsho	3203	10	in	in	IN
cord-006229-7yoilsho	3203	11	transcript	transcript	NN
cord-006229-7yoilsho	3203	12	levels	level	NNS
cord-006229-7yoilsho	3203	13	of	of	IN
cord-006229-7yoilsho	3203	14	Areg	Areg	NNP
cord-006229-7yoilsho	3203	15	and	and	CC
cord-006229-7yoilsho	3203	16	Pgr	Pgr	NNP
cord-006229-7yoilsho	3203	17	,	,	,
cord-006229-7yoilsho	3203	18	indicating	indicate	VBG
cord-006229-7yoilsho	3203	19	activation	activation	NN
cord-006229-7yoilsho	3203	20	of	of	IN
cord-006229-7yoilsho	3203	21	estrogen	estrogen	NN
cord-006229-7yoilsho	3203	22	receptor	receptor	NN
cord-006229-7yoilsho	3203	23	(	(	-LRB-
cord-006229-7yoilsho	3203	24	ER	ER	NNP
cord-006229-7yoilsho	3203	25	)	)	-RRB-
cord-006229-7yoilsho	3203	26	.	.	.
cord-006229-7yoilsho	3204	1	In	in	IN
cord-006229-7yoilsho	3204	2	contrast	contrast	NN
cord-006229-7yoilsho	3204	3	,	,	,
cord-006229-7yoilsho	3204	4	IRD	IRD	NNP
cord-006229-7yoilsho	3204	5	was	be	VBD
cord-006229-7yoilsho	3204	6	associated	associate	VBN
cord-006229-7yoilsho	3204	7	with	with	IN
cord-006229-7yoilsho	3204	8	a	a	DT
cord-006229-7yoilsho	3204	9	significant	significant	JJ
cord-006229-7yoilsho	3204	10	and	and	CC
cord-006229-7yoilsho	3204	11	IDD+IRD	idd+ird	XX
cord-006229-7yoilsho	3204	12	with	with	IN
cord-006229-7yoilsho	3204	13	a	a	DT
cord-006229-7yoilsho	3204	14	not	not	RB
cord-006229-7yoilsho	3204	15	significant	significant	JJ
cord-006229-7yoilsho	3204	16	decrease	decrease	NN
cord-006229-7yoilsho	3204	17	in	in	IN
cord-006229-7yoilsho	3204	18	Pgr	Pgr	NNP
cord-006229-7yoilsho	3204	19	transcript	transcript	NN
cord-006229-7yoilsho	3204	20	levels	level	NNS
cord-006229-7yoilsho	3204	21	.	.	.
cord-006229-7yoilsho	3205	1	E2	E2	NNP
cord-006229-7yoilsho	3205	2	levels	level	NNS
cord-006229-7yoilsho	3205	3	but	but	CC
cord-006229-7yoilsho	3205	4	not	not	RB
cord-006229-7yoilsho	3205	5	diet	diet	NN
cord-006229-7yoilsho	3205	6	were	be	VBD
cord-006229-7yoilsho	3205	7	significantly	significantly	RB
cord-006229-7yoilsho	3205	8	associated	associate	VBN
cord-006229-7yoilsho	3205	9	with	with	IN
cord-006229-7yoilsho	3205	10	Gata3	Gata3	NNP
cord-006229-7yoilsho	3205	11	transcript	transcript	NN
cord-006229-7yoilsho	3205	12	levels	level	NNS
cord-006229-7yoilsho	3205	13	,	,	,
cord-006229-7yoilsho	3205	14	indicating	indicate	VBG
cord-006229-7yoilsho	3205	15	tissue	tissue	NN
cord-006229-7yoilsho	3205	16	differentiation	differentiation	NN
cord-006229-7yoilsho	3205	17	.	.	.
cord-006229-7yoilsho	3206	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	3206	2	,	,	,
cord-006229-7yoilsho	3206	3	levels	level	NNS
cord-006229-7yoilsho	3206	4	of	of	IN
cord-006229-7yoilsho	3206	5	transcripts	transcript	NNS
cord-006229-7yoilsho	3206	6	involved	involve	VBN
cord-006229-7yoilsho	3206	7	in	in	IN
cord-006229-7yoilsho	3206	8	intercellular	intercellular	JJ
cord-006229-7yoilsho	3206	9	communication	communication	NN
cord-006229-7yoilsho	3206	10	(	(	-LRB-
cord-006229-7yoilsho	3206	11	Egfr	Egfr	NNP
cord-006229-7yoilsho	3206	12	,	,	,
cord-006229-7yoilsho	3206	13	Wnt4	Wnt4	NNP
cord-006229-7yoilsho	3206	14	)	)	-RRB-
cord-006229-7yoilsho	3206	15	were	be	VBD
cord-006229-7yoilsho	3206	16	significantly	significantly	RB
cord-006229-7yoilsho	3206	17	decreased	decrease	VBN
cord-006229-7yoilsho	3206	18	by	by	IN
cord-006229-7yoilsho	3206	19	IDD+IRD	IDD+IRD	NNP
cord-006229-7yoilsho	3206	20	and	and	CC
cord-006229-7yoilsho	3206	21	not	not	RB
cord-006229-7yoilsho	3206	22	significantly	significantly	RB
cord-006229-7yoilsho	3206	23	by	by	IN
cord-006229-7yoilsho	3206	24	IRD	IRD	NNP
cord-006229-7yoilsho	3206	25	and	and	CC
cord-006229-7yoilsho	3206	26	differed	differ	VBD
cord-006229-7yoilsho	3206	27	from	from	IN
cord-006229-7yoilsho	3206	28	that	that	DT
cord-006229-7yoilsho	3206	29	affected	affect	VBN
cord-006229-7yoilsho	3206	30	by	by	IN
cord-006229-7yoilsho	3206	31	E2	E2	NNP
cord-006229-7yoilsho	3206	32	(	(	-LRB-
cord-006229-7yoilsho	3206	33	increase	increase	NN
cord-006229-7yoilsho	3206	34	in	in	IN
cord-006229-7yoilsho	3206	35	Gdf15	Gdf15	NNP
cord-006229-7yoilsho	3206	36	,	,	,
cord-006229-7yoilsho	3206	37	Hgf	Hgf	NNP
cord-006229-7yoilsho	3206	38	,	,	,
cord-006229-7yoilsho	3206	39	Igf1r	igf1r	NN
cord-006229-7yoilsho	3206	40	,	,	,
cord-006229-7yoilsho	3206	41	Wnt5a	Wnt5a	NNP
cord-006229-7yoilsho	3206	42	)	)	-RRB-
cord-006229-7yoilsho	3206	43	.	.	.
cord-006229-7yoilsho	3207	1	Bmf	Bmf	NNP
cord-006229-7yoilsho	3207	2	,	,	,
cord-006229-7yoilsho	3208	1	a	a	DT
cord-006229-7yoilsho	3208	2	marker	marker	NN
cord-006229-7yoilsho	3208	3	transcript	transcript	NN
cord-006229-7yoilsho	3208	4	for	for	IN
cord-006229-7yoilsho	3208	5	apoptosis	apoptosis	NN
cord-006229-7yoilsho	3208	6	was	be	VBD
cord-006229-7yoilsho	3208	7	increased	increase	VBN
cord-006229-7yoilsho	3208	8	by	by	IN
cord-006229-7yoilsho	3208	9	IRD	IRD	NNP
cord-006229-7yoilsho	3208	10	,	,	,
cord-006229-7yoilsho	3208	11	but	but	CC
cord-006229-7yoilsho	3208	12	not	not	RB
cord-006229-7yoilsho	3208	13	affected	affect	VBN
cord-006229-7yoilsho	3208	14	by	by	IN
cord-006229-7yoilsho	3208	15	E2	E2	NNP
cord-006229-7yoilsho	3208	16	and	and	CC
cord-006229-7yoilsho	3208	17	even	even	RB
cord-006229-7yoilsho	3208	18	decreased	decrease	VBD
cord-006229-7yoilsho	3208	19	not	not	RB
cord-006229-7yoilsho	3208	20	significantly	significantly	RB
cord-006229-7yoilsho	3208	21	by	by	IN
cord-006229-7yoilsho	3208	22	IDD+IRD	IDD+IRD	NNP
cord-006229-7yoilsho	3208	23	.	.	.
cord-006229-7yoilsho	3209	1	Taken	take	VBN
cord-006229-7yoilsho	3209	2	together	together	RB
cord-006229-7yoilsho	3209	3	,	,	,
cord-006229-7yoilsho	3209	4	despite	despite	IN
cord-006229-7yoilsho	3209	5	an	an	DT
cord-006229-7yoilsho	3209	6	increase	increase	NN
cord-006229-7yoilsho	3209	7	in	in	IN
cord-006229-7yoilsho	3209	8	E2	E2	NNP
cord-006229-7yoilsho	3209	9	levels	level	NNS
cord-006229-7yoilsho	3209	10	in	in	IN
cord-006229-7yoilsho	3209	11	PL	pl	NN
cord-006229-7yoilsho	3209	12	,	,	,
cord-006229-7yoilsho	3209	13	less	less	JJR
cord-006229-7yoilsho	3209	14	ER	ER	NNP
cord-006229-7yoilsho	3209	15	activation	activation	NN
cord-006229-7yoilsho	3209	16	was	be	VBD
cord-006229-7yoilsho	3209	17	observed	observe	VBN
cord-006229-7yoilsho	3209	18	after	after	IN
cord-006229-7yoilsho	3209	19	dietary	dietary	JJ
cord-006229-7yoilsho	3209	20	exposure	exposure	NN
cord-006229-7yoilsho	3209	21	to	to	IN
cord-006229-7yoilsho	3209	22	IF	if	NN
cord-006229-7yoilsho	3209	23	.	.	.
cord-006229-7yoilsho	3210	1	Whereas	whereas	IN
cord-006229-7yoilsho	3210	2	E2	E2	NNP
cord-006229-7yoilsho	3210	3	and	and	CC
cord-006229-7yoilsho	3210	4	transcript	transcript	NN
cord-006229-7yoilsho	3210	5	levels	level	NNS
cord-006229-7yoilsho	3210	6	of	of	IN
cord-006229-7yoilsho	3210	7	enzymes	enzyme	NNS
cord-006229-7yoilsho	3210	8	involved	involve	VBN
cord-006229-7yoilsho	3210	9	in	in	IN
cord-006229-7yoilsho	3210	10	E2	E2	NNP
cord-006229-7yoilsho	3210	11	(	(	-LRB-
cord-006229-7yoilsho	3210	12	biotrans)formation	biotrans)formation	NNP
cord-006229-7yoilsho	3210	13	as	as	RB
cord-006229-7yoilsho	3210	14	well	well	RB
cord-006229-7yoilsho	3210	15	as	as	IN
cord-006229-7yoilsho	3210	16	ER	ER	NNP
cord-006229-7yoilsho	3210	17	activation	activation	NN
cord-006229-7yoilsho	3210	18	and	and	CC
cord-006229-7yoilsho	3210	19	cellular	cellular	JJ
cord-006229-7yoilsho	3210	20	communication	communication	NN
cord-006229-7yoilsho	3210	21	were	be	VBD
cord-006229-7yoilsho	3210	22	affected	affect	VBN
cord-006229-7yoilsho	3210	23	similarly	similarly	RB
cord-006229-7yoilsho	3210	24	but	but	CC
cord-006229-7yoilsho	3210	25	to	to	IN
cord-006229-7yoilsho	3210	26	a	a	DT
cord-006229-7yoilsho	3210	27	different	different	JJ
cord-006229-7yoilsho	3210	28	extend	extend	NN
cord-006229-7yoilsho	3210	29	in	in	IN
cord-006229-7yoilsho	3210	30	both	both	CC
cord-006229-7yoilsho	3210	31	Asian	asian	JJ
cord-006229-7yoilsho	3210	32	and	and	CC
cord-006229-7yoilsho	3210	33	Western	western	JJ
cord-006229-7yoilsho	3210	34	IF	if	IN
cord-006229-7yoilsho	3210	35	exposure	exposure	NN
cord-006229-7yoilsho	3210	36	scenarios	scenario	NNS
cord-006229-7yoilsho	3210	37	,	,	,
cord-006229-7yoilsho	3210	38	differences	difference	NNS
cord-006229-7yoilsho	3210	39	in	in	IN
cord-006229-7yoilsho	3210	40	apoptosis	apoptosis	NN
cord-006229-7yoilsho	3210	41	were	be	VBD
cord-006229-7yoilsho	3210	42	observed	observe	VBN
cord-006229-7yoilsho	3210	43	between	between	IN
cord-006229-7yoilsho	3210	44	IRD	IRD	NNP
cord-006229-7yoilsho	3210	45	and	and	CC
cord-006229-7yoilsho	3210	46	IDD+IRD	IDD+IRD	NNP
cord-006229-7yoilsho	3210	47	groups	group	NNS
cord-006229-7yoilsho	3210	48	.	.	.
cord-006229-7yoilsho	3211	1	Supported	support	VBN
cord-006229-7yoilsho	3211	2	by	by	IN
cord-006229-7yoilsho	3211	3	DFG	DFG	NNP
cord-006229-7yoilsho	3211	4	LE	LE	NNP
cord-006229-7yoilsho	3211	5	1329/10	1329/10	CD
cord-006229-7yoilsho	3211	6	-	-	SYM
cord-006229-7yoilsho	3211	7	1	1	CD
cord-006229-7yoilsho	3211	8	.	.	.
cord-006229-7yoilsho	3212	1	August	August	NNP
cord-006229-7yoilsho	3212	2	Copenhagen	Copenhagen	NNP
cord-006229-7yoilsho	3212	3	Irish	Irish	NNP
cord-006229-7yoilsho	3212	4	(	(	-LRB-
cord-006229-7yoilsho	3212	5	ACI	ACI	NNP
cord-006229-7yoilsho	3212	6	)	)	-RRB-
cord-006229-7yoilsho	3212	7	rats	rat	NNS
cord-006229-7yoilsho	3212	8	with	with	IN
cord-006229-7yoilsho	3212	9	17β	17β	NNS
cord-006229-7yoilsho	3212	10	-	-	HYPH
cord-006229-7yoilsho	3212	11	estradiol	estradiol	NN
cord-006229-7yoilsho	3213	1	(	(	-LRB-
cord-006229-7yoilsho	3213	2	E2)-releasing	e2)-release	VBG
cord-006229-7yoilsho	3213	3	implants	implant	NNS
cord-006229-7yoilsho	3213	4	are	be	VBP
cord-006229-7yoilsho	3213	5	an	an	DT
cord-006229-7yoilsho	3213	6	accepted	accepted	JJ
cord-006229-7yoilsho	3213	7	model	model	NN
cord-006229-7yoilsho	3213	8	to	to	TO
cord-006229-7yoilsho	3213	9	study	study	VB
cord-006229-7yoilsho	3213	10	the	the	DT
cord-006229-7yoilsho	3213	11	etiology	etiology	NN
cord-006229-7yoilsho	3213	12	of	of	IN
cord-006229-7yoilsho	3213	13	breast	breast	NN
cord-006229-7yoilsho	3213	14	cancer	cancer	NN
cord-006229-7yoilsho	3213	15	,	,	,
cord-006229-7yoilsho	3213	16	but	but	CC
cord-006229-7yoilsho	3213	17	neither	neither	CC
cord-006229-7yoilsho	3213	18	E2	E2	NNP
cord-006229-7yoilsho	3213	19	(	(	-LRB-
cord-006229-7yoilsho	3213	20	biotrans)formation	biotrans)formation	NNP
cord-006229-7yoilsho	3213	21	in	in	IN
cord-006229-7yoilsho	3213	22	mammary	mammary	JJ
cord-006229-7yoilsho	3213	23	gland	gland	NN
cord-006229-7yoilsho	3213	24	tissues	tissue	NNS
cord-006229-7yoilsho	3213	25	(	(	-LRB-
cord-006229-7yoilsho	3213	26	MG	MG	NNP
cord-006229-7yoilsho	3213	27	)	)	-RRB-
cord-006229-7yoilsho	3213	28	during	during	IN
cord-006229-7yoilsho	3213	29	tumorigenesis	tumorigenesis	NN
cord-006229-7yoilsho	3213	30	,	,	,
cord-006229-7yoilsho	3213	31	nor	nor	CC
cord-006229-7yoilsho	3213	32	the	the	DT
cord-006229-7yoilsho	3213	33	impact	impact	NN
cord-006229-7yoilsho	3213	34	of	of	IN
cord-006229-7yoilsho	3213	35	isoflavones	isoflavone	NNS
cord-006229-7yoilsho	3213	36	(	(	-LRB-
cord-006229-7yoilsho	3213	37	IF	if	NN
cord-006229-7yoilsho	3213	38	)	)	-RRB-
cord-006229-7yoilsho	3213	39	shown	show	VBN
cord-006229-7yoilsho	3213	40	to	to	TO
cord-006229-7yoilsho	3213	41	affect	affect	VB
cord-006229-7yoilsho	3213	42	tumorigenesis	tumorigenesis	NN
cord-006229-7yoilsho	3213	43	in	in	IN
cord-006229-7yoilsho	3213	44	ACI	ACI	NNP
cord-006229-7yoilsho	3213	45	rats	rat	NNS
cord-006229-7yoilsho	3213	46	,	,	,
cord-006229-7yoilsho	3213	47	has	have	VBZ
cord-006229-7yoilsho	3213	48	been	be	VBN
cord-006229-7yoilsho	3213	49	investigated	investigate	VBN
cord-006229-7yoilsho	3213	50	,	,	,
cord-006229-7yoilsho	3213	51	yet	yet	RB
cord-006229-7yoilsho	3213	52	.	.	.
cord-006229-7yoilsho	3214	1	Therefore	therefore	RB
cord-006229-7yoilsho	3214	2	at	at	IN
cord-006229-7yoilsho	3214	3	postnatal	postnatal	JJ
cord-006229-7yoilsho	3214	4	day	day	NN
cord-006229-7yoilsho	3214	5	(	(	-LRB-
cord-006229-7yoilsho	3214	6	PND	PND	NNP
cord-006229-7yoilsho	3214	7	)	)	-RRB-
cord-006229-7yoilsho	3214	8	75	75	CD
cord-006229-7yoilsho	3214	9	and	and	CC
cord-006229-7yoilsho	3214	10	175	175	CD
cord-006229-7yoilsho	3214	11	,	,	,
cord-006229-7yoilsho	3214	12	placebo	placebo	NN
cord-006229-7yoilsho	3214	13	(	(	-LRB-
cord-006229-7yoilsho	3214	14	-E2	-E2	NFP
cord-006229-7yoilsho	3214	15	)	)	-RRB-
cord-006229-7yoilsho	3214	16	or	or	CC
cord-006229-7yoilsho	3214	17	silastic	silastic	JJ
cord-006229-7yoilsho	3214	18	implants	implant	NNS
cord-006229-7yoilsho	3214	19	containing	contain	VBG
cord-006229-7yoilsho	3214	20	4	4	CD
cord-006229-7yoilsho	3214	21	mg	mg	NNP
cord-006229-7yoilsho	3214	22	E2	E2	NNP
cord-006229-7yoilsho	3214	23	were	be	VBD
cord-006229-7yoilsho	3214	24	implanted	implant	VBN
cord-006229-7yoilsho	3214	25	in	in	IN
cord-006229-7yoilsho	3214	26	female	female	JJ
cord-006229-7yoilsho	3214	27	ACI	ACI	NNP
cord-006229-7yoilsho	3214	28	rats	rat	NNS
cord-006229-7yoilsho	3214	29	exposed	expose	VBN
cord-006229-7yoilsho	3214	30	to	to	IN
cord-006229-7yoilsho	3214	31	either	either	DT
cord-006229-7yoilsho	3215	1	IF	if	IN
cord-006229-7yoilsho	3215	2	depleted	deplete	VBN
cord-006229-7yoilsho	3215	3	diet	diet	NN
cord-006229-7yoilsho	3215	4	(	(	-LRB-
cord-006229-7yoilsho	3215	5	IDD	IDD	NNP
cord-006229-7yoilsho	3215	6	)	)	-RRB-
cord-006229-7yoilsho	3215	7	or	or	CC
cord-006229-7yoilsho	3215	8	IF	if	IN
cord-006229-7yoilsho	3215	9	rich	rich	JJ
cord-006229-7yoilsho	3215	10	diet	diet	NN
cord-006229-7yoilsho	3215	11	(	(	-LRB-
cord-006229-7yoilsho	3215	12	IRD	IRD	NNP
cord-006229-7yoilsho	3215	13	)	)	-RRB-
cord-006229-7yoilsho	3215	14	since	since	IN
cord-006229-7yoilsho	3215	15	conception	conception	NN
cord-006229-7yoilsho	3215	16	until	until	IN
cord-006229-7yoilsho	3215	17	the	the	DT
cord-006229-7yoilsho	3215	18	end	end	NN
cord-006229-7yoilsho	3215	19	of	of	IN
cord-006229-7yoilsho	3215	20	the	the	DT
cord-006229-7yoilsho	3215	21	study	study	NN
cord-006229-7yoilsho	3215	22	at	at	IN
cord-006229-7yoilsho	3215	23	PND	PND	NNP
cord-006229-7yoilsho	3215	24	285	285	CD
cord-006229-7yoilsho	3215	25	.	.	.
cord-006229-7yoilsho	3216	1	Palpable	palpable	JJ
cord-006229-7yoilsho	3216	2	MG	MG	NNP
cord-006229-7yoilsho	3216	3	tumors	tumor	NNS
cord-006229-7yoilsho	3216	4	(	(	-LRB-
cord-006229-7yoilsho	3216	5	PT	PT	NNP
cord-006229-7yoilsho	3216	6	)	)	-RRB-
cord-006229-7yoilsho	3216	7	and	and	CC
cord-006229-7yoilsho	3216	8	1	1	CD
cord-006229-7yoilsho	3216	9	-	-	SYM
cord-006229-7yoilsho	3216	10	2	2	CD
cord-006229-7yoilsho	3216	11	MG	MG	NNP
cord-006229-7yoilsho	3216	12	per	per	IN
cord-006229-7yoilsho	3216	13	animal	animal	NN
cord-006229-7yoilsho	3216	14	without	without	IN
cord-006229-7yoilsho	3216	15	PT	PT	NNP
cord-006229-7yoilsho	3216	16	were	be	VBD
cord-006229-7yoilsho	3216	17	characterized	characterize	VBN
cord-006229-7yoilsho	3216	18	histologically	histologically	RB
cord-006229-7yoilsho	3216	19	and	and	CC
cord-006229-7yoilsho	3216	20	categorized	categorize	VBN
cord-006229-7yoilsho	3216	21	into	into	IN
cord-006229-7yoilsho	3216	22	normal	normal	JJ
cord-006229-7yoilsho	3216	23	(	(	-LRB-
cord-006229-7yoilsho	3216	24	-E2	-E2	:
cord-006229-7yoilsho	3216	25	group	group	NN
cord-006229-7yoilsho	3216	26	,	,	,
cord-006229-7yoilsho	3216	27	n=12	n=12	NNP
cord-006229-7yoilsho	3216	28	)	)	-RRB-
cord-006229-7yoilsho	3216	29	,	,	,
cord-006229-7yoilsho	3216	30	hyperplasia	hyperplasia	NN
cord-006229-7yoilsho	3216	31	and	and	CC
cord-006229-7yoilsho	3216	32	non	non	JJ
cord-006229-7yoilsho	3216	33	-	-	NN
cord-006229-7yoilsho	3216	34	PT	pt	NN
cord-006229-7yoilsho	3216	35	and	and	CC
cord-006229-7yoilsho	3216	36	PT	PT	NNP
cord-006229-7yoilsho	3216	37	with	with	IN
cord-006229-7yoilsho	3216	38	and	and	CC
cord-006229-7yoilsho	3216	39	without	without	IN
cord-006229-7yoilsho	3216	40	solid	solid	JJ
cord-006229-7yoilsho	3216	41	tumors	tumor	NNS
cord-006229-7yoilsho	3216	42	(	(	-LRB-
cord-006229-7yoilsho	3216	43	+	+	CC
cord-006229-7yoilsho	3216	44	E2	E2	NNP
cord-006229-7yoilsho	3216	45	group	group	NN
cord-006229-7yoilsho	3216	46	,	,	,
cord-006229-7yoilsho	3216	47	n=32	n=32	NNP
cord-006229-7yoilsho	3216	48	)	)	-RRB-
cord-006229-7yoilsho	3216	49	.	.	.
cord-006229-7yoilsho	3217	1	E2	E2	NNP
cord-006229-7yoilsho	3217	2	,	,	,
cord-006229-7yoilsho	3217	3	estrone	estrone	NN
cord-006229-7yoilsho	3217	4	(	(	-LRB-
cord-006229-7yoilsho	3217	5	E1	E1	NNP
cord-006229-7yoilsho	3217	6	)	)	-RRB-
cord-006229-7yoilsho	3217	7	,	,	,
cord-006229-7yoilsho	3217	8	their	-PRON-	PRP$
cord-006229-7yoilsho	3217	9	hydroxylation	hydroxylation	NN
cord-006229-7yoilsho	3217	10	products	product	NNS
cord-006229-7yoilsho	3217	11	and	and	CC
cord-006229-7yoilsho	3217	12	methylation	methylation	NN
cord-006229-7yoilsho	3217	13	(	(	-LRB-
cord-006229-7yoilsho	3217	14	MeO-	MeO-	NNP
cord-006229-7yoilsho	3217	15	)	)	-RRB-
cord-006229-7yoilsho	3217	16	products	product	NNS
cord-006229-7yoilsho	3217	17	thereof	thereof	RB
cord-006229-7yoilsho	3217	18	,	,	,
cord-006229-7yoilsho	3217	19	as	as	RB
cord-006229-7yoilsho	3217	20	well	well	RB
cord-006229-7yoilsho	3217	21	as	as	IN
cord-006229-7yoilsho	3217	22	conjugates	conjugate	NNS
cord-006229-7yoilsho	3217	23	of	of	IN
cord-006229-7yoilsho	3217	24	E1	E1	NNP
cord-006229-7yoilsho	3217	25	and	and	CC
cord-006229-7yoilsho	3217	26	E2	E2	NNP
cord-006229-7yoilsho	3217	27	in	in	IN
cord-006229-7yoilsho	3217	28	plasmas	plasma	NNS
cord-006229-7yoilsho	3217	29	and	and	CC
cord-006229-7yoilsho	3217	30	MG	MG	NNP
cord-006229-7yoilsho	3217	31	were	be	VBD
cord-006229-7yoilsho	3217	32	analyzed	analyze	VBN
cord-006229-7yoilsho	3217	33	by	by	IN
cord-006229-7yoilsho	3217	34	GC	GC	NNP
cord-006229-7yoilsho	3217	35	-	-	:
cord-006229-7yoilsho	3217	36	and	and	CC
cord-006229-7yoilsho	3217	37	UHPLC	UHPLC	NNP
cord-006229-7yoilsho	3217	38	-	-	HYPH
cord-006229-7yoilsho	3217	39	MS	MS	NNP
cord-006229-7yoilsho	3217	40	/	/	SYM
cord-006229-7yoilsho	3217	41	MS	MS	NNP
cord-006229-7yoilsho	3217	42	,	,	,
cord-006229-7yoilsho	3217	43	respectively	respectively	RB
cord-006229-7yoilsho	3217	44	.	.	.
cord-006229-7yoilsho	3218	1	Levels	level	NNS
cord-006229-7yoilsho	3218	2	of	of	IN
cord-006229-7yoilsho	3218	3	49	49	CD
cord-006229-7yoilsho	3218	4	transcripts	transcript	NNS
cord-006229-7yoilsho	3218	5	involved	involve	VBN
cord-006229-7yoilsho	3218	6	in	in	IN
cord-006229-7yoilsho	3218	7	(	(	-LRB-
cord-006229-7yoilsho	3218	8	biotrans)formation	biotrans)formation	NNP
cord-006229-7yoilsho	3218	9	of	of	IN
cord-006229-7yoilsho	3218	10	E2	E2	NNP
cord-006229-7yoilsho	3218	11	and	and	CC
cord-006229-7yoilsho	3218	12	estrogen	estrogen	NN
cord-006229-7yoilsho	3218	13	receptor	receptor	NN
cord-006229-7yoilsho	3218	14	(	(	-LRB-
cord-006229-7yoilsho	3218	15	ER	ER	NNP
cord-006229-7yoilsho	3218	16	)	)	-RRB-
cord-006229-7yoilsho	3218	17	activation	activation	NN
cord-006229-7yoilsho	3218	18	were	be	VBD
cord-006229-7yoilsho	3218	19	determined	determine	VBN
cord-006229-7yoilsho	3218	20	by	by	IN
cord-006229-7yoilsho	3218	21	TaqMan	TaqMan	NNP
cord-006229-7yoilsho	3219	1	®	®	VB
cord-006229-7yoilsho	3219	2	-PCR	-pcr	ADD
cord-006229-7yoilsho	3219	3	.	.	.
cord-006229-7yoilsho	3220	1	Without	without	IN
cord-006229-7yoilsho	3220	2	exogenous	exogenous	JJ
cord-006229-7yoilsho	3220	3	E2	E2	NNP
cord-006229-7yoilsho	3220	4	,	,	,
cord-006229-7yoilsho	3220	5	plasma	plasma	NN
cord-006229-7yoilsho	3220	6	E2	E2	NNP
cord-006229-7yoilsho	3220	7	as	as	RB
cord-006229-7yoilsho	3220	8	well	well	RB
cord-006229-7yoilsho	3220	9	as	as	IN
cord-006229-7yoilsho	3220	10	E1	e1	NN
cord-006229-7yoilsho	3220	11	and	and	CC
cord-006229-7yoilsho	3220	12	(	(	-LRB-
cord-006229-7yoilsho	3220	13	borderline	borderline	JJ
cord-006229-7yoilsho	3220	14	)	)	-RRB-
cord-006229-7yoilsho	3220	15	E2	E2	NNP
cord-006229-7yoilsho	3220	16	levels	level	NNS
cord-006229-7yoilsho	3220	17	in	in	IN
cord-006229-7yoilsho	3220	18	MG	MG	NNP
cord-006229-7yoilsho	3220	19	were	be	VBD
cord-006229-7yoilsho	3220	20	higher	high	JJR
cord-006229-7yoilsho	3220	21	in	in	IN
cord-006229-7yoilsho	3220	22	IRD	IRD	NNP
cord-006229-7yoilsho	3220	23	.	.	.
cord-006229-7yoilsho	3221	1	Plasma	plasma	NN
cord-006229-7yoilsho	3221	2	E2	E2	NNP
cord-006229-7yoilsho	3221	3	as	as	RB
cord-006229-7yoilsho	3221	4	well	well	RB
cord-006229-7yoilsho	3221	5	as	as	IN
cord-006229-7yoilsho	3221	6	E1	e1	NN
cord-006229-7yoilsho	3221	7	and	and	CC
cord-006229-7yoilsho	3221	8	E2	E2	NNP
cord-006229-7yoilsho	3221	9	levels	level	NNS
cord-006229-7yoilsho	3221	10	in	in	IN
cord-006229-7yoilsho	3221	11	MG	MG	NNP
cord-006229-7yoilsho	3221	12	were	be	VBD
cord-006229-7yoilsho	3221	13	lower	low	JJR
cord-006229-7yoilsho	3221	14	in	in	IN
cord-006229-7yoilsho	3221	15	the	the	DT
cord-006229-7yoilsho	3221	16	-E2	-E2	JJS
cord-006229-7yoilsho	3221	17	group	group	NN
cord-006229-7yoilsho	3221	18	than	than	IN
cord-006229-7yoilsho	3221	19	that	that	DT
cord-006229-7yoilsho	3221	20	in	in	IN
cord-006229-7yoilsho	3221	21	the	the	DT
cord-006229-7yoilsho	3221	22	+	+	CD
cord-006229-7yoilsho	3221	23	E2	E2	NNP
cord-006229-7yoilsho	3221	24	group	group	NN
cord-006229-7yoilsho	3221	25	.	.	.
cord-006229-7yoilsho	3222	1	E2	E2	NNP
cord-006229-7yoilsho	3222	2	levels	level	NNS
cord-006229-7yoilsho	3222	3	as	as	RB
cord-006229-7yoilsho	3222	4	well	well	RB
cord-006229-7yoilsho	3222	5	as	as	IN
cord-006229-7yoilsho	3222	6	E2	E2	NNP
cord-006229-7yoilsho	3222	7	/	/	SYM
cord-006229-7yoilsho	3222	8	E1	E1	NNP
cord-006229-7yoilsho	3222	9	and	and	CC
cord-006229-7yoilsho	3222	10	E2	E2	NNP
cord-006229-7yoilsho	3222	11	MG	MG	NNP
cord-006229-7yoilsho	3222	12	/	/	SYM
cord-006229-7yoilsho	3222	13	plasma	plasma	NN
cord-006229-7yoilsho	3222	14	ratios	ratio	NNS
cord-006229-7yoilsho	3222	15	were	be	VBD
cord-006229-7yoilsho	3222	16	elevated	elevate	VBN
cord-006229-7yoilsho	3222	17	in	in	IN
cord-006229-7yoilsho	3222	18	PT	PT	NNP
cord-006229-7yoilsho	3222	19	,	,	,
cord-006229-7yoilsho	3222	20	accompanied	accompany	VBN
cord-006229-7yoilsho	3222	21	by	by	IN
cord-006229-7yoilsho	3222	22	a	a	DT
cord-006229-7yoilsho	3222	23	significant	significant	JJ
cord-006229-7yoilsho	3222	24	increase	increase	NN
cord-006229-7yoilsho	3222	25	in	in	IN
cord-006229-7yoilsho	3222	26	transcript	transcript	NN
cord-006229-7yoilsho	3222	27	levels	level	NNS
cord-006229-7yoilsho	3222	28	indicative	indicative	JJ
cord-006229-7yoilsho	3222	29	for	for	IN
cord-006229-7yoilsho	3222	30	estrogen	estrogen	NN
cord-006229-7yoilsho	3222	31	receptor	receptor	NN
cord-006229-7yoilsho	3222	32	activation	activation	NN
cord-006229-7yoilsho	3222	33	(	(	-LRB-
cord-006229-7yoilsho	3222	34	Areg	Areg	NNP
cord-006229-7yoilsho	3222	35	,	,	,
cord-006229-7yoilsho	3222	36	Pgr	Pgr	NNP
cord-006229-7yoilsho	3222	37	)	)	-RRB-
cord-006229-7yoilsho	3222	38	and	and	CC
cord-006229-7yoilsho	3222	39	proliferation	proliferation	NN
cord-006229-7yoilsho	3222	40	(	(	-LRB-
cord-006229-7yoilsho	3222	41	Mki67	Mki67	NNP
cord-006229-7yoilsho	3222	42	)	)	-RRB-
cord-006229-7yoilsho	3222	43	.	.	.
cord-006229-7yoilsho	3223	1	IRD	IRD	NNP
cord-006229-7yoilsho	3223	2	increased	increase	VBD
cord-006229-7yoilsho	3223	3	E2	E2	NNP
cord-006229-7yoilsho	3223	4	/	/	SYM
cord-006229-7yoilsho	3223	5	E1	e1	NN
cord-006229-7yoilsho	3223	6	ratio	ratio	NN
cord-006229-7yoilsho	3223	7	in	in	IN
cord-006229-7yoilsho	3223	8	PT	PT	NNP
cord-006229-7yoilsho	3223	9	and	and	CC
cord-006229-7yoilsho	3223	10	,	,	,
cord-006229-7yoilsho	3223	11	although	although	IN
cord-006229-7yoilsho	3223	12	IRD	IRD	NNP
cord-006229-7yoilsho	3223	13	did	do	VBD
cord-006229-7yoilsho	3223	14	not	not	RB
cord-006229-7yoilsho	3223	15	affect	affect	VB
cord-006229-7yoilsho	3223	16	ER	ER	NNP
cord-006229-7yoilsho	3223	17	activation	activation	NN
cord-006229-7yoilsho	3223	18	(	(	-LRB-
cord-006229-7yoilsho	3223	19	Areg	Areg	NNP
cord-006229-7yoilsho	3223	20	,	,	,
cord-006229-7yoilsho	3223	21	Pgr	Pgr	NNP
cord-006229-7yoilsho	3223	22	)	)	-RRB-
cord-006229-7yoilsho	3223	23	,	,	,
cord-006229-7yoilsho	3223	24	IRD	IRD	NNP
cord-006229-7yoilsho	3223	25	increased	increase	VBN
cord-006229-7yoilsho	3223	26	differentiation	differentiation	NN
cord-006229-7yoilsho	3223	27	(	(	-LRB-
cord-006229-7yoilsho	3223	28	Gata3	gata3	NN
cord-006229-7yoilsho	3223	29	)	)	-RRB-
cord-006229-7yoilsho	3223	30	in	in	IN
cord-006229-7yoilsho	3223	31	normal	normal	JJ
cord-006229-7yoilsho	3223	32	and	and	CC
cord-006229-7yoilsho	3223	33	hyperplastic	hyperplastic	JJ
cord-006229-7yoilsho	3223	34	tissues	tissue	NNS
cord-006229-7yoilsho	3223	35	and	and	CC
cord-006229-7yoilsho	3223	36	tended	tend	VBD
cord-006229-7yoilsho	3223	37	to	to	TO
cord-006229-7yoilsho	3223	38	decrease	decrease	VB
cord-006229-7yoilsho	3223	39	proliferation	proliferation	NN
cord-006229-7yoilsho	3223	40	in	in	IN
cord-006229-7yoilsho	3223	41	hyperplastic	hyperplastic	JJ
cord-006229-7yoilsho	3223	42	(	(	-LRB-
cord-006229-7yoilsho	3223	43	Ccnd1	ccnd1	NN
cord-006229-7yoilsho	3223	44	)	)	-RRB-
cord-006229-7yoilsho	3223	45	tissues	tissue	NNS
cord-006229-7yoilsho	3223	46	.	.	.
cord-006229-7yoilsho	3224	1	Levels	level	NNS
cord-006229-7yoilsho	3224	2	of	of	IN
cord-006229-7yoilsho	3224	3	E1	e1	NN
cord-006229-7yoilsho	3224	4	and	and	CC
cord-006229-7yoilsho	3224	5	2-MeO	2-meo	CD
cord-006229-7yoilsho	3224	6	-	-	HYPH
cord-006229-7yoilsho	3224	7	E1	E1	NNP
cord-006229-7yoilsho	3224	8	were	be	VBD
cord-006229-7yoilsho	3224	9	highest	high	JJS
cord-006229-7yoilsho	3224	10	in	in	IN
cord-006229-7yoilsho	3224	11	hyperplastic	hyperplastic	JJ
cord-006229-7yoilsho	3224	12	tissues	tissue	NNS
cord-006229-7yoilsho	3224	13	,	,	,
cord-006229-7yoilsho	3224	14	accompanied	accompany	VBN
cord-006229-7yoilsho	3224	15	by	by	IN
cord-006229-7yoilsho	3224	16	an	an	DT
cord-006229-7yoilsho	3224	17	increase	increase	NN
cord-006229-7yoilsho	3224	18	in	in	IN
cord-006229-7yoilsho	3224	19	transcript	transcript	NN
cord-006229-7yoilsho	3224	20	levels	level	NNS
cord-006229-7yoilsho	3224	21	of	of	IN
cord-006229-7yoilsho	3224	22	Hsd17b2	Hsd17b2	NNP
cord-006229-7yoilsho	3224	23	(	(	-LRB-
cord-006229-7yoilsho	3224	24	conversion	conversion	NN
cord-006229-7yoilsho	3224	25	E2	E2	NNP
cord-006229-7yoilsho	3224	26	to	to	IN
cord-006229-7yoilsho	3224	27	E1	E1	NNP
cord-006229-7yoilsho	3224	28	)	)	-RRB-
cord-006229-7yoilsho	3224	29	and	and	CC
cord-006229-7yoilsho	3224	30	Cyp1a1	Cyp1a1	NNP
cord-006229-7yoilsho	3224	31	.	.	.
cord-006229-7yoilsho	3225	1	Transcript	Transcript	NNP
cord-006229-7yoilsho	3225	2	levels	level	NNS
cord-006229-7yoilsho	3225	3	of	of	IN
cord-006229-7yoilsho	3225	4	Gstm1	Gstm1	NNP
cord-006229-7yoilsho	3225	5	and	and	CC
cord-006229-7yoilsho	3225	6	Gstm2	Gstm2	NNS
cord-006229-7yoilsho	3225	7	were	be	VBD
cord-006229-7yoilsho	3225	8	decreased	decrease	VBN
cord-006229-7yoilsho	3225	9	in	in	IN
cord-006229-7yoilsho	3225	10	the	the	DT
cord-006229-7yoilsho	3225	11	whole	whole	JJ
cord-006229-7yoilsho	3225	12	+	+	CC
cord-006229-7yoilsho	3225	13	E2	E2	NNP
cord-006229-7yoilsho	3225	14	group	group	NN
cord-006229-7yoilsho	3225	15	and	and	CC
cord-006229-7yoilsho	3225	16	of	of	IN
cord-006229-7yoilsho	3225	17	Gstt1	Gstt1	NNP
cord-006229-7yoilsho	3225	18	and	and	CC
cord-006229-7yoilsho	3225	19	Gstt3	gstt3	JJ
cord-006229-7yoilsho	3225	20	in	in	IN
cord-006229-7yoilsho	3225	21	hyperplastic	hyperplastic	JJ
cord-006229-7yoilsho	3225	22	tissues	tissue	NNS
cord-006229-7yoilsho	3225	23	,	,	,
cord-006229-7yoilsho	3225	24	possibly	possibly	RB
cord-006229-7yoilsho	3225	25	decreasing	decrease	VBG
cord-006229-7yoilsho	3225	26	inactivation	inactivation	NN
cord-006229-7yoilsho	3225	27	of	of	IN
cord-006229-7yoilsho	3225	28	electrophilic	electrophilic	JJ
cord-006229-7yoilsho	3225	29	metabolites	metabolite	NNS
cord-006229-7yoilsho	3225	30	.	.	.
cord-006229-7yoilsho	3226	1	Accordingly	accordingly	RB
cord-006229-7yoilsho	3226	2	,	,	,
cord-006229-7yoilsho	3226	3	maximum	maximum	JJ
cord-006229-7yoilsho	3226	4	transcript	transcript	NN
cord-006229-7yoilsho	3226	5	levels	level	NNS
cord-006229-7yoilsho	3226	6	of	of	IN
cord-006229-7yoilsho	3227	1	Tp53	Tp53	NNP
cord-006229-7yoilsho	3227	2	and	and	CC
cord-006229-7yoilsho	3227	3	MT1a	MT1a	NNP
cord-006229-7yoilsho	3227	4	indicating	indicate	VBG
cord-006229-7yoilsho	3227	5	cellular	cellular	JJ
cord-006229-7yoilsho	3227	6	(	(	-LRB-
cord-006229-7yoilsho	3227	7	oxidative	oxidative	JJ
cord-006229-7yoilsho	3227	8	)	)	-RRB-
cord-006229-7yoilsho	3227	9	stress	stress	NN
cord-006229-7yoilsho	3227	10	were	be	VBD
cord-006229-7yoilsho	3227	11	observed	observe	VBN
cord-006229-7yoilsho	3227	12	in	in	IN
cord-006229-7yoilsho	3227	13	hyperplastic	hyperplastic	JJ
cord-006229-7yoilsho	3227	14	tissues	tissue	NNS
cord-006229-7yoilsho	3227	15	.	.	.
cord-006229-7yoilsho	3228	1	IRD	IRD	NNP
cord-006229-7yoilsho	3228	2	did	do	VBD
cord-006229-7yoilsho	3228	3	neither	neither	DT
cord-006229-7yoilsho	3228	4	affect	affect	VB
cord-006229-7yoilsho	3228	5	levels	level	NNS
cord-006229-7yoilsho	3228	6	of	of	IN
cord-006229-7yoilsho	3228	7	2-MeO	2-meo	CD
cord-006229-7yoilsho	3228	8	-	-	HYPH
cord-006229-7yoilsho	3228	9	E1	e1	NN
cord-006229-7yoilsho	3228	10	nor	nor	CC
cord-006229-7yoilsho	3228	11	cellular	cellular	JJ
cord-006229-7yoilsho	3228	12	stress	stress	NN
cord-006229-7yoilsho	3228	13	(	(	-LRB-
cord-006229-7yoilsho	3228	14	Gclc	Gclc	NNP
cord-006229-7yoilsho	3228	15	,	,	,
cord-006229-7yoilsho	3228	16	Mt1a	Mt1a	NNP
cord-006229-7yoilsho	3228	17	,	,	,
cord-006229-7yoilsho	3228	18	Tp53	Tp53	NNP
cord-006229-7yoilsho	3228	19	)	)	-RRB-
cord-006229-7yoilsho	3228	20	.	.	.
cord-006229-7yoilsho	3229	1	Of	of	IN
cord-006229-7yoilsho	3229	2	note	note	NN
cord-006229-7yoilsho	3229	3	,	,	,
cord-006229-7yoilsho	3229	4	neither	neither	CC
cord-006229-7yoilsho	3229	5	4-MeO	4-meo	CD
cord-006229-7yoilsho	3229	6	-	-	HYPH
cord-006229-7yoilsho	3229	7	E1	e1	NN
cord-006229-7yoilsho	3229	8	,	,	,
cord-006229-7yoilsho	3229	9	nor	nor	CC
cord-006229-7yoilsho	3229	10	E1	E1	NNP
cord-006229-7yoilsho	3229	11	catechols	catechol	NNS
cord-006229-7yoilsho	3229	12	,	,	,
cord-006229-7yoilsho	3229	13	nor	nor	CC
cord-006229-7yoilsho	3229	14	E2	E2	NNP
cord-006229-7yoilsho	3229	15	catechols	catechol	NNS
cord-006229-7yoilsho	3229	16	nor	nor	CC
cord-006229-7yoilsho	3229	17	methylation	methylation	NN
cord-006229-7yoilsho	3229	18	products	product	NNS
cord-006229-7yoilsho	3229	19	of	of	IN
cord-006229-7yoilsho	3229	20	the	the	DT
cord-006229-7yoilsho	3229	21	latter	latter	JJ
cord-006229-7yoilsho	3229	22	were	be	VBD
cord-006229-7yoilsho	3229	23	observed	observe	VBN
cord-006229-7yoilsho	3229	24	in	in	IN
cord-006229-7yoilsho	3229	25	any	any	DT
cord-006229-7yoilsho	3229	26	sample	sample	NN
cord-006229-7yoilsho	3229	27	.	.	.
cord-006229-7yoilsho	3230	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	3230	2	,	,	,
cord-006229-7yoilsho	3230	3	no	no	DT
cord-006229-7yoilsho	3230	4	conjugates	conjugate	NNS
cord-006229-7yoilsho	3230	5	of	of	IN
cord-006229-7yoilsho	3230	6	E1	e1	NN
cord-006229-7yoilsho	3230	7	or	or	CC
cord-006229-7yoilsho	3230	8	E2	E2	NNP
cord-006229-7yoilsho	3230	9	were	be	VBD
cord-006229-7yoilsho	3230	10	detected	detect	VBN
cord-006229-7yoilsho	3230	11	in	in	IN
cord-006229-7yoilsho	3230	12	plasmas	plasma	NNS
cord-006229-7yoilsho	3230	13	and	and	CC
cord-006229-7yoilsho	3230	14	mammary	mammary	JJ
cord-006229-7yoilsho	3230	15	gland	gland	NN
cord-006229-7yoilsho	3230	16	tissues	tissue	NNS
cord-006229-7yoilsho	3230	17	.	.	.
cord-006229-7yoilsho	3231	1	Thus	thus	RB
cord-006229-7yoilsho	3231	2	,	,	,
cord-006229-7yoilsho	3231	3	changes	change	NNS
cord-006229-7yoilsho	3231	4	in	in	IN
cord-006229-7yoilsho	3231	5	transcript	transcript	NN
cord-006229-7yoilsho	3231	6	levels	level	NNS
cord-006229-7yoilsho	3231	7	of	of	IN
cord-006229-7yoilsho	3231	8	conjugating	conjugate	VBG
cord-006229-7yoilsho	3231	9	enzymes	enzyme	NNS
cord-006229-7yoilsho	3231	10	induced	induce	VBN
cord-006229-7yoilsho	3231	11	by	by	IN
cord-006229-7yoilsho	3231	12	tumorigenesis	tumorigenesis	NN
cord-006229-7yoilsho	3231	13	and	and	CC
cord-006229-7yoilsho	3231	14	by	by	IN
cord-006229-7yoilsho	3231	15	IRD	IRD	NNP
cord-006229-7yoilsho	3231	16	were	be	VBD
cord-006229-7yoilsho	3231	17	not	not	RB
cord-006229-7yoilsho	3231	18	related	relate	VBN
cord-006229-7yoilsho	3231	19	with	with	IN
cord-006229-7yoilsho	3231	20	detectable	detectable	JJ
cord-006229-7yoilsho	3231	21	conjugate	conjugate	JJ
cord-006229-7yoilsho	3231	22	levels	level	NNS
cord-006229-7yoilsho	3231	23	of	of	IN
cord-006229-7yoilsho	3231	24	E1	e1	NN
cord-006229-7yoilsho	3231	25	or	or	CC
cord-006229-7yoilsho	3231	26	E2	E2	NNP
cord-006229-7yoilsho	3231	27	.	.	.
cord-006229-7yoilsho	3232	1	Taken	take	VBN
cord-006229-7yoilsho	3232	2	together	together	RB
cord-006229-7yoilsho	3232	3	,	,	,
cord-006229-7yoilsho	3232	4	whereas	whereas	IN
cord-006229-7yoilsho	3232	5	hyperplastic	hyperplastic	JJ
cord-006229-7yoilsho	3232	6	tissues	tissue	NNS
cord-006229-7yoilsho	3232	7	were	be	VBD
cord-006229-7yoilsho	3232	8	characterized	characterize	VBN
cord-006229-7yoilsho	3232	9	by	by	IN
cord-006229-7yoilsho	3232	10	maximum	maximum	JJ
cord-006229-7yoilsho	3232	11	oxidative	oxidative	JJ
cord-006229-7yoilsho	3232	12	metabolism	metabolism	NN
cord-006229-7yoilsho	3232	13	of	of	IN
cord-006229-7yoilsho	3232	14	E1	e1	NN
cord-006229-7yoilsho	3232	15	and	and	CC
cord-006229-7yoilsho	3232	16	cellular	cellular	JJ
cord-006229-7yoilsho	3232	17	(	(	-LRB-
cord-006229-7yoilsho	3232	18	oxidative	oxidative	JJ
cord-006229-7yoilsho	3232	19	)	)	-RRB-
cord-006229-7yoilsho	3232	20	stress	stress	NN
cord-006229-7yoilsho	3232	21	,	,	,
cord-006229-7yoilsho	3232	22	PT	PT	NNP
cord-006229-7yoilsho	3232	23	exhibited	exhibit	VBD
cord-006229-7yoilsho	3232	24	highest	high	JJS
cord-006229-7yoilsho	3232	25	E2	E2	NNP
cord-006229-7yoilsho	3232	26	levels	level	NNS
cord-006229-7yoilsho	3232	27	and	and	CC
cord-006229-7yoilsho	3232	28	ER	ER	NNP
cord-006229-7yoilsho	3232	29	activation	activation	NN
cord-006229-7yoilsho	3232	30	.	.	.
cord-006229-7yoilsho	3233	1	IRD	IRD	NNP
cord-006229-7yoilsho	3233	2	increased	increase	VBN
cord-006229-7yoilsho	3233	3	differentiation	differentiation	NN
cord-006229-7yoilsho	3233	4	and	and	CC
cord-006229-7yoilsho	3233	5	decreased	decrease	VBD
cord-006229-7yoilsho	3233	6	proliferation	proliferation	NN
cord-006229-7yoilsho	3233	7	in	in	IN
cord-006229-7yoilsho	3233	8	normal	normal	JJ
cord-006229-7yoilsho	3233	9	and	and	CC
cord-006229-7yoilsho	3233	10	hyperplastic	hyperplastic	JJ
cord-006229-7yoilsho	3233	11	tissues	tissue	NNS
cord-006229-7yoilsho	3233	12	but	but	CC
cord-006229-7yoilsho	3233	13	increased	increase	VBN
cord-006229-7yoilsho	3233	14	E2	E2	NNP
cord-006229-7yoilsho	3233	15	/	/	SYM
cord-006229-7yoilsho	3233	16	E1	e1	NN
cord-006229-7yoilsho	3233	17	ratio	ratio	NN
cord-006229-7yoilsho	3233	18	in	in	IN
cord-006229-7yoilsho	3233	19	PT	PT	NNP
cord-006229-7yoilsho	3233	20	.	.	.
cord-006229-7yoilsho	3234	1	Supported	support	VBN
cord-006229-7yoilsho	3234	2	by	by	IN
cord-006229-7yoilsho	3234	3	DFG	DFG	NNP
cord-006229-7yoilsho	3234	4	Le-1329/10	Le-1329/10	.
cord-006229-7yoilsho	3235	1	-1	-1	JJ
cord-006229-7yoilsho	3235	2	.	.	.
cord-006229-7yoilsho	3236	1	Level	level	NN
cord-006229-7yoilsho	3236	2	of	of	IN
cord-006229-7yoilsho	3236	3	17beta	17beta	NN
cord-006229-7yoilsho	3236	4	-	-	HYPH
cord-006229-7yoilsho	3236	5	estradiol	estradiol	NN
cord-006229-7yoilsho	3236	6	(	(	-LRB-
cord-006229-7yoilsho	3236	7	E2	E2	NNP
cord-006229-7yoilsho	3236	8	)	)	-RRB-
cord-006229-7yoilsho	3236	9	in	in	IN
cord-006229-7yoilsho	3236	10	human	human	JJ
cord-006229-7yoilsho	3236	11	breast	breast	NN
cord-006229-7yoilsho	3236	12	tissue	tissue	NN
cord-006229-7yoilsho	3236	13	is	be	VBZ
cord-006229-7yoilsho	3236	14	considered	consider	VBN
cord-006229-7yoilsho	3236	15	to	to	TO
cord-006229-7yoilsho	3236	16	affect	affect	VB
cord-006229-7yoilsho	3236	17	breast	breast	NN
cord-006229-7yoilsho	3236	18	cancer	cancer	NN
cord-006229-7yoilsho	3236	19	initiation	initiation	NN
cord-006229-7yoilsho	3236	20	,	,	,
cord-006229-7yoilsho	3236	21	promotion	promotion	NN
cord-006229-7yoilsho	3236	22	and	and	CC
cord-006229-7yoilsho	3236	23	progression	progression	NN
cord-006229-7yoilsho	3236	24	.	.	.
cord-006229-7yoilsho	3237	1	Although	although	IN
cord-006229-7yoilsho	3237	2	putatively	putatively	RB
cord-006229-7yoilsho	3237	3	beneficial	beneficial	JJ
cord-006229-7yoilsho	3237	4	and	and	CC
cord-006229-7yoilsho	3237	5	adverse	adverse	JJ
cord-006229-7yoilsho	3237	6	effects	effect	NNS
cord-006229-7yoilsho	3237	7	of	of	IN
cord-006229-7yoilsho	3237	8	soy	soy	NN
cord-006229-7yoilsho	3237	9	isoflavones	isoflavone	NNS
cord-006229-7yoilsho	3237	10	(	(	-LRB-
cord-006229-7yoilsho	3237	11	IF	if	IN
cord-006229-7yoilsho	3237	12	)	)	-RRB-
cord-006229-7yoilsho	3237	13	on	on	IN
cord-006229-7yoilsho	3237	14	the	the	DT
cord-006229-7yoilsho	3237	15	human	human	JJ
cord-006229-7yoilsho	3237	16	mammary	mammary	JJ
cord-006229-7yoilsho	3237	17	gland	gland	NN
cord-006229-7yoilsho	3237	18	,	,	,
cord-006229-7yoilsho	3237	19	in	in	IN
cord-006229-7yoilsho	3237	20	particular	particular	JJ
cord-006229-7yoilsho	3237	21	in	in	IN
cord-006229-7yoilsho	3237	22	Western	western	JJ
cord-006229-7yoilsho	3237	23	women	woman	NNS
cord-006229-7yoilsho	3237	24	,	,	,
cord-006229-7yoilsho	3237	25	have	have	VBP
cord-006229-7yoilsho	3237	26	been	be	VBN
cord-006229-7yoilsho	3237	27	discussed	discuss	VBN
cord-006229-7yoilsho	3237	28	extensively	extensively	RB
cord-006229-7yoilsho	3237	29	,	,	,
cord-006229-7yoilsho	3237	30	the	the	DT
cord-006229-7yoilsho	3237	31	influence	influence	NN
cord-006229-7yoilsho	3237	32	of	of	IN
cord-006229-7yoilsho	3237	33	IF	if	IN
cord-006229-7yoilsho	3237	34	levels	level	NNS
cord-006229-7yoilsho	3237	35	on	on	IN
cord-006229-7yoilsho	3237	36	estrogen	estrogen	NN
cord-006229-7yoilsho	3237	37	formation	formation	NN
cord-006229-7yoilsho	3237	38	in	in	IN
cord-006229-7yoilsho	3237	39	human	human	JJ
cord-006229-7yoilsho	3237	40	mammary	mammary	JJ
cord-006229-7yoilsho	3237	41	gland	gland	NN
cord-006229-7yoilsho	3237	42	tissue	tissue	NN
cord-006229-7yoilsho	3237	43	has	have	VBZ
cord-006229-7yoilsho	3237	44	not	not	RB
cord-006229-7yoilsho	3237	45	been	be	VBN
cord-006229-7yoilsho	3237	46	investigated	investigate	VBN
cord-006229-7yoilsho	3237	47	yet	yet	RB
cord-006229-7yoilsho	3237	48	.	.	.
cord-006229-7yoilsho	3238	1	Thus	thus	RB
cord-006229-7yoilsho	3238	2	,	,	,
cord-006229-7yoilsho	3238	3	glandular	glandular	JJ
cord-006229-7yoilsho	3238	4	tissues	tissue	NNS
cord-006229-7yoilsho	3238	5	were	be	VBD
cord-006229-7yoilsho	3238	6	dissected	dissect	VBN
cord-006229-7yoilsho	3238	7	from	from	IN
cord-006229-7yoilsho	3238	8	37	37	CD
cord-006229-7yoilsho	3238	9	mammoplasty	mammoplasty	JJ
cord-006229-7yoilsho	3238	10	specimen	specimen	NN
cord-006229-7yoilsho	3238	11	obtained	obtain	VBN
cord-006229-7yoilsho	3238	12	from	from	IN
cord-006229-7yoilsho	3238	13	women	woman	NNS
cord-006229-7yoilsho	3238	14	(	(	-LRB-
cord-006229-7yoilsho	3238	15	age	age	NN
cord-006229-7yoilsho	3238	16	18	18	CD
cord-006229-7yoilsho	3238	17	-	-	SYM
cord-006229-7yoilsho	3238	18	66	66	CD
cord-006229-7yoilsho	3238	19	years	year	NNS
cord-006229-7yoilsho	3238	20	old	old	JJ
cord-006229-7yoilsho	3238	21	)	)	-RRB-
cord-006229-7yoilsho	3238	22	not	not	RB
cord-006229-7yoilsho	3238	23	taking	take	VBG
cord-006229-7yoilsho	3238	24	estrogen	estrogen	NN
cord-006229-7yoilsho	3238	25	active	active	JJ
cord-006229-7yoilsho	3238	26	drugs	drug	NNS
cord-006229-7yoilsho	3238	27	.	.	.
cord-006229-7yoilsho	3239	1	14	14	CD
cord-006229-7yoilsho	3239	2	of	of	IN
cord-006229-7yoilsho	3239	3	these	these	DT
cord-006229-7yoilsho	3239	4	women	woman	NNS
cord-006229-7yoilsho	3239	5	had	have	VBD
cord-006229-7yoilsho	3239	6	been	be	VBN
cord-006229-7yoilsho	3239	7	exposed	expose	VBN
cord-006229-7yoilsho	3239	8	to	to	IN
cord-006229-7yoilsho	3239	9	IF	if	NN
cord-006229-7yoilsho	3239	10	by	by	IN
cord-006229-7yoilsho	3239	11	their	-PRON-	PRP$
cord-006229-7yoilsho	3239	12	usual	usual	JJ
cord-006229-7yoilsho	3239	13	diet	diet	NN
cord-006229-7yoilsho	3239	14	or	or	CC
cord-006229-7yoilsho	3239	15	by	by	IN
cord-006229-7yoilsho	3239	16	intake	intake	NN
cord-006229-7yoilsho	3239	17	of	of	IN
cord-006229-7yoilsho	3239	18	a	a	DT
cord-006229-7yoilsho	3239	19	soy	soy	NN
cord-006229-7yoilsho	3239	20	-	-	HYPH
cord-006229-7yoilsho	3239	21	based	base	VBN
cord-006229-7yoilsho	3239	22	dietary	dietary	JJ
cord-006229-7yoilsho	3239	23	supplement	supplement	NN
cord-006229-7yoilsho	3239	24	for	for	IN
cord-006229-7yoilsho	3239	25	7	7	CD
cord-006229-7yoilsho	3239	26	days	day	NNS
cord-006229-7yoilsho	3239	27	prior	prior	RB
cord-006229-7yoilsho	3239	28	to	to	IN
cord-006229-7yoilsho	3239	29	mammoplasty	mammoplasty	NNP
cord-006229-7yoilsho	3239	30	.	.	.
cord-006229-7yoilsho	3240	1	Information	information	NN
cord-006229-7yoilsho	3240	2	on	on	IN
cord-006229-7yoilsho	3240	3	soy	soy	NN
cord-006229-7yoilsho	3240	4	consumption	consumption	NN
cord-006229-7yoilsho	3240	5	and	and	CC
cord-006229-7yoilsho	3240	6	lifestyle	lifestyle	NN
cord-006229-7yoilsho	3240	7	were	be	VBD
cord-006229-7yoilsho	3240	8	collected	collect	VBN
cord-006229-7yoilsho	3240	9	by	by	IN
cord-006229-7yoilsho	3240	10	questionnaire	questionnaire	NN
cord-006229-7yoilsho	3240	11	and	and	CC
cord-006229-7yoilsho	3240	12	tissues	tissue	NNS
cord-006229-7yoilsho	3240	13	were	be	VBD
cord-006229-7yoilsho	3240	14	characterized	characterize	VBN
cord-006229-7yoilsho	3240	15	histologically	histologically	RB
cord-006229-7yoilsho	3240	16	.	.	.
cord-006229-7yoilsho	3241	1	Genistein	Genistein	NNP
cord-006229-7yoilsho	3241	2	,	,	,
cord-006229-7yoilsho	3241	3	daidzein	daidzein	VBP
cord-006229-7yoilsho	3241	4	their	-PRON-	PRP$
cord-006229-7yoilsho	3241	5	conjugates	conjugate	NNS
cord-006229-7yoilsho	3241	6	(	(	-LRB-
cord-006229-7yoilsho	3241	7	n=12	n=12	NNP
cord-006229-7yoilsho	3241	8	)	)	-RRB-
cord-006229-7yoilsho	3241	9	and	and	CC
cord-006229-7yoilsho	3241	10	bacterial	bacterial	JJ
cord-006229-7yoilsho	3241	11	metabolites	metabolite	NNS
cord-006229-7yoilsho	3241	12	(	(	-LRB-
cord-006229-7yoilsho	3241	13	n=7	n=7	NNS
cord-006229-7yoilsho	3241	14	)	)	-RRB-
cord-006229-7yoilsho	3241	15	as	as	RB
cord-006229-7yoilsho	3241	16	well	well	RB
cord-006229-7yoilsho	3241	17	as	as	IN
cord-006229-7yoilsho	3241	18	the	the	DT
cord-006229-7yoilsho	3241	19	estrogens	estrogen	NNS
cord-006229-7yoilsho	3241	20	estrone	estrone	NN
cord-006229-7yoilsho	3241	21	(	(	-LRB-
cord-006229-7yoilsho	3241	22	E1)-sulfate	E1)-sulfate	NNP
cord-006229-7yoilsho	3241	23	,	,	,
cord-006229-7yoilsho	3241	24	E1	E1	NNP
cord-006229-7yoilsho	3241	25	,	,	,
cord-006229-7yoilsho	3241	26	E2	E2	NNP
cord-006229-7yoilsho	3241	27	and	and	CC
cord-006229-7yoilsho	3241	28	2-methoxy	2-methoxy	CD
cord-006229-7yoilsho	3241	29	-	-	HYPH
cord-006229-7yoilsho	3241	30	E1	E1	NNP
cord-006229-7yoilsho	3241	31	were	be	VBD
cord-006229-7yoilsho	3241	32	determined	determine	VBN
cord-006229-7yoilsho	3241	33	by	by	IN
cord-006229-7yoilsho	3241	34	UHPLCand	uhplcand	JJ
cord-006229-7yoilsho	3241	35	GC	GC	NNP
cord-006229-7yoilsho	3241	36	-	-	HYPH
cord-006229-7yoilsho	3241	37	MS	MS	NNP
cord-006229-7yoilsho	3241	38	/	/	SYM
cord-006229-7yoilsho	3241	39	MS	MS	NNP
cord-006229-7yoilsho	3241	40	,	,	,
cord-006229-7yoilsho	3241	41	respectively	respectively	RB
cord-006229-7yoilsho	3241	42	and	and	CC
cord-006229-7yoilsho	3241	43	transcript	transcript	NN
cord-006229-7yoilsho	3241	44	levels	level	NNS
cord-006229-7yoilsho	3241	45	of	of	IN
cord-006229-7yoilsho	3241	46	19	19	CD
cord-006229-7yoilsho	3241	47	enzymes	enzyme	NNS
cord-006229-7yoilsho	3241	48	involved	involve	VBN
cord-006229-7yoilsho	3241	49	in	in	IN
cord-006229-7yoilsho	3241	50	E2	E2	NNP
cord-006229-7yoilsho	3241	51	(	(	-LRB-
cord-006229-7yoilsho	3241	52	biotrans)formation	biotrans)formation	NNP
cord-006229-7yoilsho	3241	53	were	be	VBD
cord-006229-7yoilsho	3241	54	quantified	quantify	VBN
cord-006229-7yoilsho	3241	55	by	by	IN
cord-006229-7yoilsho	3241	56	TaqMan	TaqMan	NNP
cord-006229-7yoilsho	3241	57	®	®	POS
cord-006229-7yoilsho	3241	58	-PCR	-PCR	-LRB-
cord-006229-7yoilsho	3241	59	in	in	IN
cord-006229-7yoilsho	3241	60	glandular	glandular	JJ
cord-006229-7yoilsho	3241	61	tissues	tissue	NNS
cord-006229-7yoilsho	3241	62	.	.	.
cord-006229-7yoilsho	3242	1	Isoflavonoids	Isoflavonoids	NNP
cord-006229-7yoilsho	3242	2	were	be	VBD
cord-006229-7yoilsho	3242	3	categorized	categorize	VBN
cord-006229-7yoilsho	3242	4	into	into	IN
cord-006229-7yoilsho	3242	5	the	the	DT
cord-006229-7yoilsho	3242	6	IF	if	NN
cord-006229-7yoilsho	3242	7	parameters	parameter	NNS
cord-006229-7yoilsho	3242	8	aglycones	aglycone	NNS
cord-006229-7yoilsho	3242	9	(	(	-LRB-
cord-006229-7yoilsho	3242	10	Agl	Agl	NNP
cord-006229-7yoilsho	3242	11	)	)	-RRB-
cord-006229-7yoilsho	3242	12	and	and	CC
cord-006229-7yoilsho	3242	13	conjugates	conjugate	NNS
cord-006229-7yoilsho	3242	14	(	(	-LRB-
cord-006229-7yoilsho	3242	15	Con	con	NN
cord-006229-7yoilsho	3242	16	)	)	-RRB-
cord-006229-7yoilsho	3242	17	of	of	IN
cord-006229-7yoilsho	3242	18	either	either	CC
cord-006229-7yoilsho	3242	19	genistein	genistein	NNP
cord-006229-7yoilsho	3242	20	,	,	,
cord-006229-7yoilsho	3242	21	daidzein	daidzein	NN
cord-006229-7yoilsho	3242	22	or	or	CC
cord-006229-7yoilsho	3242	23	sum	sum	VB
cord-006229-7yoilsho	3242	24	of	of	IN
cord-006229-7yoilsho	3242	25	both	both	DT
cord-006229-7yoilsho	3242	26	and	and	CC
cord-006229-7yoilsho	3242	27	were	be	VBD
cord-006229-7yoilsho	3242	28	further	further	RB
cord-006229-7yoilsho	3242	29	statistically	statistically	RB
cord-006229-7yoilsho	3242	30	analyzed	analyze	VBN
cord-006229-7yoilsho	3242	31	by	by	IN
cord-006229-7yoilsho	3242	32	Spearman`s	spearman`s	CC
cord-006229-7yoilsho	3242	33	rank	rank	NN
cord-006229-7yoilsho	3242	34	correlation	correlation	NN
cord-006229-7yoilsho	3242	35	analysis	analysis	NN
cord-006229-7yoilsho	3242	36	.	.	.
cord-006229-7yoilsho	3243	1	A	a	DT
cord-006229-7yoilsho	3243	2	positive	positive	JJ
cord-006229-7yoilsho	3243	3	correlation	correlation	NN
cord-006229-7yoilsho	3243	4	of	of	IN
cord-006229-7yoilsho	3243	5	E2	E2	NNP
cord-006229-7yoilsho	3243	6	/	/	SYM
cord-006229-7yoilsho	3243	7	E1	e1	NN
cord-006229-7yoilsho	3243	8	ratio	ratio	NN
cord-006229-7yoilsho	3243	9	with	with	IN
cord-006229-7yoilsho	3243	10	Agl(+Con	Agl(+Con	NNP
cord-006229-7yoilsho	3243	11	)	)	-RRB-
cord-006229-7yoilsho	3243	12	was	be	VBD
cord-006229-7yoilsho	3243	13	observed	observe	VBN
cord-006229-7yoilsho	3243	14	in	in	IN
cord-006229-7yoilsho	3243	15	glandular	glandular	JJ
cord-006229-7yoilsho	3243	16	tissues	tissue	NNS
cord-006229-7yoilsho	3243	17	(	(	-LRB-
cord-006229-7yoilsho	3243	18	R=0.49	R=0.49	NNP
cord-006229-7yoilsho	3243	19	,	,	,
cord-006229-7yoilsho	3243	20	p=0.002	p=0.002	NNP
cord-006229-7yoilsho	3243	21	)	)	-RRB-
cord-006229-7yoilsho	3243	22	,	,	,
cord-006229-7yoilsho	3243	23	accompanied	accompany	VBN
cord-006229-7yoilsho	3243	24	by	by	IN
cord-006229-7yoilsho	3243	25	a	a	DT
cord-006229-7yoilsho	3243	26	significant	significant	JJ
cord-006229-7yoilsho	3243	27	negative	negative	JJ
cord-006229-7yoilsho	3243	28	correlation	correlation	NN
cord-006229-7yoilsho	3243	29	of	of	IN
cord-006229-7yoilsho	3243	30	E1	e1	NN
cord-006229-7yoilsho	3243	31	levels	level	NNS
cord-006229-7yoilsho	3243	32	with	with	IN
cord-006229-7yoilsho	3243	33	Agl	Agl	NNP
cord-006229-7yoilsho	3243	34	(	(	-LRB-
cord-006229-7yoilsho	3243	35	R=-0.35	R=-0.35	NNP
cord-006229-7yoilsho	3243	36	/	/	SYM
cord-006229-7yoilsho	3243	37	p=0.032	p=0.032	NNPS
cord-006229-7yoilsho	3243	38	)	)	-RRB-
cord-006229-7yoilsho	3243	39	,	,	,
cord-006229-7yoilsho	3243	40	possibly	possibly	RB
cord-006229-7yoilsho	3243	41	due	due	IN
cord-006229-7yoilsho	3243	42	to	to	IN
cord-006229-7yoilsho	3243	43	reduction	reduction	NN
cord-006229-7yoilsho	3243	44	of	of	IN
cord-006229-7yoilsho	3243	45	17beta	17beta	JJ
cord-006229-7yoilsho	3243	46	-	-	HYPH
cord-006229-7yoilsho	3243	47	hydroxysteroid	hydroxysteroid	NN
cord-006229-7yoilsho	3243	48	dehydrogenase	dehydrogenase	NN
cord-006229-7yoilsho	3243	49	2	2	CD
cord-006229-7yoilsho	3243	50	(	(	-LRB-
cord-006229-7yoilsho	3243	51	conversion	conversion	NN
cord-006229-7yoilsho	3243	52	of	of	IN
cord-006229-7yoilsho	3243	53	E2	E2	NNP
cord-006229-7yoilsho	3243	54	to	to	IN
cord-006229-7yoilsho	3243	55	E1	E1	NNP
cord-006229-7yoilsho	3243	56	)	)	-RRB-
cord-006229-7yoilsho	3243	57	expression	expression	NN
cord-006229-7yoilsho	3243	58	as	as	IN
cord-006229-7yoilsho	3243	59	indicated	indicate	VBN
cord-006229-7yoilsho	3243	60	by	by	IN
cord-006229-7yoilsho	3243	61	a	a	DT
cord-006229-7yoilsho	3243	62	weak	weak	JJ
cord-006229-7yoilsho	3243	63	negative	negative	JJ
cord-006229-7yoilsho	3243	64	correlation	correlation	NN
cord-006229-7yoilsho	3243	65	of	of	IN
cord-006229-7yoilsho	3243	66	transcript	transcript	NN
cord-006229-7yoilsho	3243	67	levels	level	NNS
cord-006229-7yoilsho	3243	68	of	of	IN
cord-006229-7yoilsho	3243	69	17beta	17beta	CD
cord-006229-7yoilsho	3243	70	-	-	HYPH
cord-006229-7yoilsho	3243	71	hydroxysteroid	hydroxysteroid	NN
cord-006229-7yoilsho	3243	72	dehydrogenase	dehydrogenase	NN
cord-006229-7yoilsho	3243	73	2	2	CD
cord-006229-7yoilsho	3243	74	with	with	IN
cord-006229-7yoilsho	3243	75	Agl+Con	Agl+Con	NNP
cord-006229-7yoilsho	3243	76	(	(	-LRB-
cord-006229-7yoilsho	3243	77	R=-0.25	R=-0.25	NNP
cord-006229-7yoilsho	3243	78	,	,	,
cord-006229-7yoilsho	3243	79	p=0.080	p=0.080	NNP
cord-006229-7yoilsho	3243	80	)	)	-RRB-
cord-006229-7yoilsho	3243	81	.	.	.
cord-006229-7yoilsho	3244	1	Further	further	JJ
cord-006229-7yoilsho	3244	2	statistical	statistical	JJ
cord-006229-7yoilsho	3244	3	analysis	analysis	NN
cord-006229-7yoilsho	3244	4	taking	take	VBG
cord-006229-7yoilsho	3244	5	into	into	IN
cord-006229-7yoilsho	3244	6	account	account	NN
cord-006229-7yoilsho	3244	7	multiple	multiple	JJ
cord-006229-7yoilsho	3244	8	variables	variable	NNS
cord-006229-7yoilsho	3244	9	using	use	VBG
cord-006229-7yoilsho	3244	10	linear	linear	JJ
cord-006229-7yoilsho	3244	11	regression	regression	NN
cord-006229-7yoilsho	3244	12	models	model	NNS
cord-006229-7yoilsho	3244	13	will	will	MD
cord-006229-7yoilsho	3244	14	provide	provide	VB
cord-006229-7yoilsho	3244	15	more	more	JJR
cord-006229-7yoilsho	3244	16	insights	insight	NNS
cord-006229-7yoilsho	3244	17	into	into	IN
cord-006229-7yoilsho	3244	18	variables	variable	NNS
cord-006229-7yoilsho	3244	19	affecting	affect	VBG
cord-006229-7yoilsho	3244	20	E1	e1	NN
cord-006229-7yoilsho	3244	21	/	/	SYM
cord-006229-7yoilsho	3244	22	E2	e2	NN
cord-006229-7yoilsho	3244	23	ratio	ratio	NN
cord-006229-7yoilsho	3244	24	.	.	.
cord-006229-7yoilsho	3245	1	Taken	take	VBN
cord-006229-7yoilsho	3245	2	together	together	RB
cord-006229-7yoilsho	3245	3	,	,	,
cord-006229-7yoilsho	3245	4	estrogen	estrogen	NN
cord-006229-7yoilsho	3245	5	profile	profile	NN
cord-006229-7yoilsho	3245	6	in	in	IN
cord-006229-7yoilsho	3245	7	human	human	JJ
cord-006229-7yoilsho	3245	8	glandular	glandular	JJ
cord-006229-7yoilsho	3245	9	breast	breast	NN
cord-006229-7yoilsho	3245	10	tissue	tissue	NN
cord-006229-7yoilsho	3245	11	seems	seem	VBZ
cord-006229-7yoilsho	3245	12	to	to	TO
cord-006229-7yoilsho	3245	13	be	be	VB
cord-006229-7yoilsho	3245	14	affected	affect	VBN
cord-006229-7yoilsho	3245	15	by	by	IN
cord-006229-7yoilsho	3245	16	IF	if	NN
cord-006229-7yoilsho	3245	17	levels	level	NNS
cord-006229-7yoilsho	3245	18	.	.	.
cord-006229-7yoilsho	3246	1	Supported	support	VBN
cord-006229-7yoilsho	3246	2	by	by	IN
cord-006229-7yoilsho	3246	3	DFG	DFG	NNP
cord-006229-7yoilsho	3246	4	Le-1329/10	Le-1329/10	.
cord-006229-7yoilsho	3247	1	-1	-1	JJ
cord-006229-7yoilsho	3247	2	.	.	.
cord-006229-7yoilsho	3248	1	Allergic	allergic	JJ
cord-006229-7yoilsho	3248	2	contact	contact	NN
cord-006229-7yoilsho	3248	3	dermatitis	dermatitis	NN
cord-006229-7yoilsho	3248	4	(	(	-LRB-
cord-006229-7yoilsho	3248	5	ACD	ACD	NNP
cord-006229-7yoilsho	3248	6	)	)	-RRB-
cord-006229-7yoilsho	3248	7	is	be	VBZ
cord-006229-7yoilsho	3248	8	a	a	DT
cord-006229-7yoilsho	3248	9	widespread	widespread	JJ
cord-006229-7yoilsho	3248	10	disease	disease	NN
cord-006229-7yoilsho	3248	11	often	often	RB
cord-006229-7yoilsho	3248	12	caused	cause	VBN
cord-006229-7yoilsho	3248	13	by	by	IN
cord-006229-7yoilsho	3248	14	substances	substance	NNS
cord-006229-7yoilsho	3248	15	in	in	IN
cord-006229-7yoilsho	3248	16	consumables	consumable	NNS
cord-006229-7yoilsho	3248	17	.	.	.
cord-006229-7yoilsho	3249	1	The	the	DT
cord-006229-7yoilsho	3249	2	EU	EU	NNP
cord-006229-7yoilsho	3249	3	prohibits	prohibit	VBZ
cord-006229-7yoilsho	3249	4	the	the	DT
cord-006229-7yoilsho	3249	5	testing	testing	NN
cord-006229-7yoilsho	3249	6	of	of	IN
cord-006229-7yoilsho	3249	7	cosmetic	cosmetic	JJ
cord-006229-7yoilsho	3249	8	ingredients	ingredient	NNS
cord-006229-7yoilsho	3249	9	in	in	IN
cord-006229-7yoilsho	3249	10	vivo	vivo	NN
cord-006229-7yoilsho	3249	11	.	.	.
cord-006229-7yoilsho	3250	1	This	this	DT
cord-006229-7yoilsho	3250	2	urges	urge	VBZ
cord-006229-7yoilsho	3250	3	the	the	DT
cord-006229-7yoilsho	3250	4	development	development	NN
cord-006229-7yoilsho	3250	5	of	of	IN
cord-006229-7yoilsho	3250	6	reliable	reliable	JJ
cord-006229-7yoilsho	3250	7	in	in	IN
cord-006229-7yoilsho	3250	8	vitro	vitro	FW
cord-006229-7yoilsho	3250	9	testing	testing	NN
cord-006229-7yoilsho	3250	10	strategies	strategy	NNS
cord-006229-7yoilsho	3250	11	.	.	.
cord-006229-7yoilsho	3251	1	Activation	activation	NN
cord-006229-7yoilsho	3251	2	of	of	IN
cord-006229-7yoilsho	3251	3	dendritic	dendritic	JJ
cord-006229-7yoilsho	3251	4	cells	cell	NNS
cord-006229-7yoilsho	3251	5	(	(	-LRB-
cord-006229-7yoilsho	3251	6	DCs	DCs	NNP
cord-006229-7yoilsho	3251	7	)	)	-RRB-
cord-006229-7yoilsho	3251	8	represents	represent	VBZ
cord-006229-7yoilsho	3251	9	a	a	DT
cord-006229-7yoilsho	3251	10	key	key	JJ
cord-006229-7yoilsho	3251	11	step	step	NN
cord-006229-7yoilsho	3251	12	during	during	IN
cord-006229-7yoilsho	3251	13	sensitization	sensitization	NN
cord-006229-7yoilsho	3251	14	as	as	IN
cord-006229-7yoilsho	3251	15	they	-PRON-	PRP
cord-006229-7yoilsho	3251	16	are	be	VBP
cord-006229-7yoilsho	3251	17	essential	essential	JJ
cord-006229-7yoilsho	3251	18	for	for	IN
cord-006229-7yoilsho	3251	19	selection	selection	NN
cord-006229-7yoilsho	3251	20	and	and	CC
cord-006229-7yoilsho	3251	21	priming	priming	NN
cord-006229-7yoilsho	3251	22	of	of	IN
cord-006229-7yoilsho	3251	23	allergen	allergen	NN
cord-006229-7yoilsho	3251	24	specific	specific	JJ
cord-006229-7yoilsho	3251	25	effector	effector	NN
cord-006229-7yoilsho	3251	26	T	t	NN
cord-006229-7yoilsho	3251	27	cells	cell	NNS
cord-006229-7yoilsho	3251	28	.	.	.
cord-006229-7yoilsho	3252	1	In	in	IN
cord-006229-7yoilsho	3252	2	an	an	DT
cord-006229-7yoilsho	3252	3	integrated	integrated	JJ
cord-006229-7yoilsho	3252	4	OMICs	omic	NNS
cord-006229-7yoilsho	3252	5	approach	approach	NN
cord-006229-7yoilsho	3252	6	we	-PRON-	PRP
cord-006229-7yoilsho	3252	7	aimed	aim	VBD
cord-006229-7yoilsho	3252	8	to	to	TO
cord-006229-7yoilsho	3252	9	further	further	RB
cord-006229-7yoilsho	3252	10	elucidate	elucidate	VB
cord-006229-7yoilsho	3252	11	the	the	DT
cord-006229-7yoilsho	3252	12	molecular	molecular	JJ
cord-006229-7yoilsho	3252	13	mechanisms	mechanism	NNS
cord-006229-7yoilsho	3252	14	of	of	IN
cord-006229-7yoilsho	3252	15	DC	DC	NNP
cord-006229-7yoilsho	3252	16	activation	activation	NN
cord-006229-7yoilsho	3252	17	using	use	VBG
cord-006229-7yoilsho	3252	18	quantitative	quantitative	JJ
cord-006229-7yoilsho	3252	19	metabolomics	metabolomic	NNS
cord-006229-7yoilsho	3252	20	and	and	CC
cord-006229-7yoilsho	3252	21	proteomics	proteomic	NNS
cord-006229-7yoilsho	3252	22	.	.	.
cord-006229-7yoilsho	3253	1	Monocytic	Monocytic	NNP
cord-006229-7yoilsho	3253	2	THP-1	THP-1	NNP
cord-006229-7yoilsho	3253	3	cells	cell	NNS
cord-006229-7yoilsho	3253	4	were	be	VBD
cord-006229-7yoilsho	3253	5	used	use	VBN
cord-006229-7yoilsho	3253	6	as	as	IN
cord-006229-7yoilsho	3253	7	a	a	DT
cord-006229-7yoilsho	3253	8	model	model	NN
cord-006229-7yoilsho	3253	9	system	system	NN
cord-006229-7yoilsho	3253	10	and	and	CC
cord-006229-7yoilsho	3253	11	treated	treat	VBN
cord-006229-7yoilsho	3253	12	with	with	IN
cord-006229-7yoilsho	3253	13	the	the	DT
cord-006229-7yoilsho	3253	14	sensitizer	sensitizer	NN
cord-006229-7yoilsho	3253	15	2,4dinitrochlorobenzene	2,4dinitrochlorobenzene	CD
cord-006229-7yoilsho	3253	16	(	(	-LRB-
cord-006229-7yoilsho	3253	17	DNCB	DNCB	NNP
cord-006229-7yoilsho	3253	18	;	;	:
cord-006229-7yoilsho	3253	19	5	5	CD
cord-006229-7yoilsho	3253	20	,	,	,
cord-006229-7yoilsho	3253	21	10	10	CD
cord-006229-7yoilsho	3253	22	and	and	CC
cord-006229-7yoilsho	3253	23	20	20	CD
cord-006229-7yoilsho	3253	24	µM	µm	CD
cord-006229-7yoilsho	3253	25	)	)	-RRB-
cord-006229-7yoilsho	3253	26	and	and	CC
cord-006229-7yoilsho	3253	27	the	the	DT
cord-006229-7yoilsho	3253	28	irritant	irritant	JJ
cord-006229-7yoilsho	3253	29	sodium	sodium	NN
cord-006229-7yoilsho	3253	30	dodecyl	dodecyl	NNP
cord-006229-7yoilsho	3253	31	sulfate	sulfate	NNP
cord-006229-7yoilsho	3253	32	(	(	-LRB-
cord-006229-7yoilsho	3253	33	SDS	SDS	NNP
cord-006229-7yoilsho	3253	34	;	;	:
cord-006229-7yoilsho	3253	35	100	100	CD
cord-006229-7yoilsho	3253	36	µM	µm	NN
cord-006229-7yoilsho	3253	37	)	)	-RRB-
cord-006229-7yoilsho	3253	38	.	.	.
cord-006229-7yoilsho	3254	1	Samples	sample	NNS
cord-006229-7yoilsho	3254	2	were	be	VBD
cord-006229-7yoilsho	3254	3	taken	take	VBN
cord-006229-7yoilsho	3254	4	after	after	IN
cord-006229-7yoilsho	3254	5	4	4	CD
cord-006229-7yoilsho	3254	6	,	,	,
cord-006229-7yoilsho	3254	7	8	8	CD
cord-006229-7yoilsho	3254	8	and	and	CC
cord-006229-7yoilsho	3254	9	24	24	CD
cord-006229-7yoilsho	3254	10	hours	hour	NNS
cord-006229-7yoilsho	3254	11	.	.	.
cord-006229-7yoilsho	3255	1	THP-1	THP-1	NNP
cord-006229-7yoilsho	3255	2	activation	activation	NN
cord-006229-7yoilsho	3255	3	was	be	VBD
cord-006229-7yoilsho	3255	4	analyzed	analyze	VBN
cord-006229-7yoilsho	3255	5	by	by	IN
cord-006229-7yoilsho	3255	6	measuring	measure	VBG
cord-006229-7yoilsho	3255	7	the	the	DT
cord-006229-7yoilsho	3255	8	established	establish	VBN
cord-006229-7yoilsho	3255	9	activation	activation	NN
cord-006229-7yoilsho	3255	10	markers	marker	NNS
cord-006229-7yoilsho	3255	11	CD86	CD86	NNP
cord-006229-7yoilsho	3255	12	and	and	CC
cord-006229-7yoilsho	3255	13	CD54	CD54	NNP
cord-006229-7yoilsho	3255	14	after	after	IN
cord-006229-7yoilsho	3255	15	24	24	CD
cord-006229-7yoilsho	3255	16	hours	hour	NNS
cord-006229-7yoilsho	3255	17	.	.	.
cord-006229-7yoilsho	3256	1	A	a	DT
cord-006229-7yoilsho	3256	2	targeted	target	VBN
cord-006229-7yoilsho	3256	3	LC	LC	NNP
cord-006229-7yoilsho	3256	4	-	-	HYPH
cord-006229-7yoilsho	3256	5	MS	MS	NNP
cord-006229-7yoilsho	3256	6	/	/	SYM
cord-006229-7yoilsho	3256	7	MS	MS	NNP
cord-006229-7yoilsho	3256	8	approach	approach	NN
cord-006229-7yoilsho	3256	9	was	be	VBD
cord-006229-7yoilsho	3256	10	used	use	VBN
cord-006229-7yoilsho	3256	11	to	to	TO
cord-006229-7yoilsho	3256	12	analyze	analyze	VB
cord-006229-7yoilsho	3256	13	188	188	CD
cord-006229-7yoilsho	3256	14	metabolites	metabolite	NNS
cord-006229-7yoilsho	3256	15	including	include	VBG
cord-006229-7yoilsho	3256	16	amino	amino	NN
cord-006229-7yoilsho	3256	17	acids	acid	NNS
cord-006229-7yoilsho	3256	18	and	and	CC
cord-006229-7yoilsho	3256	19	lipids	lipid	NNS
cord-006229-7yoilsho	3256	20	.	.	.
cord-006229-7yoilsho	3257	1	Protein	protein	NN
cord-006229-7yoilsho	3257	2	levels	level	NNS
cord-006229-7yoilsho	3257	3	were	be	VBD
cord-006229-7yoilsho	3257	4	quantified	quantify	VBN
cord-006229-7yoilsho	3257	5	by	by	IN
cord-006229-7yoilsho	3257	6	nano	nano	NNP
cord-006229-7yoilsho	3257	7	-	-	HYPH
cord-006229-7yoilsho	3257	8	LC	LC	NNP
cord-006229-7yoilsho	3257	9	-	-	HYPH
cord-006229-7yoilsho	3257	10	MALDI	MALDI	NNP
cord-006229-7yoilsho	3257	11	-	-	HYPH
cord-006229-7yoilsho	3257	12	MS	MS	NNP
cord-006229-7yoilsho	3257	13	/	/	SYM
cord-006229-7yoilsho	3257	14	MS	MS	NNP
cord-006229-7yoilsho	3257	15	after	after	IN
cord-006229-7yoilsho	3257	16	stable	stable	JJ
cord-006229-7yoilsho	3257	17	isotope	isotope	NN
cord-006229-7yoilsho	3257	18	labeling	labeling	NN
cord-006229-7yoilsho	3257	19	by	by	IN
cord-006229-7yoilsho	3257	20	amino	amino	JJ
cord-006229-7yoilsho	3257	21	acids	acid	NNS
cord-006229-7yoilsho	3257	22	in	in	IN
cord-006229-7yoilsho	3257	23	cell	cell	NN
cord-006229-7yoilsho	3257	24	culture	culture	NN
cord-006229-7yoilsho	3257	25	(	(	-LRB-
cord-006229-7yoilsho	3257	26	SILAC	SILAC	NNP
cord-006229-7yoilsho	3257	27	)	)	-RRB-
cord-006229-7yoilsho	3257	28	.	.	.
cord-006229-7yoilsho	3258	1	Data	datum	NNS
cord-006229-7yoilsho	3258	2	sets	set	NNS
cord-006229-7yoilsho	3258	3	were	be	VBD
cord-006229-7yoilsho	3258	4	examined	examine	VBN
cord-006229-7yoilsho	3258	5	by	by	IN
cord-006229-7yoilsho	3258	6	multivariate	multivariate	JJ
cord-006229-7yoilsho	3258	7	analyses	analysis	NNS
cord-006229-7yoilsho	3258	8	for	for	IN
cord-006229-7yoilsho	3258	9	identification	identification	NN
cord-006229-7yoilsho	3258	10	of	of	IN
cord-006229-7yoilsho	3258	11	biomarker	biomarker	NN
cord-006229-7yoilsho	3258	12	candidates	candidate	NNS
cord-006229-7yoilsho	3258	13	.	.	.
cord-006229-7yoilsho	3259	1	Regulated	regulated	JJ
cord-006229-7yoilsho	3259	2	metabolites	metabolite	NNS
cord-006229-7yoilsho	3259	3	and	and	CC
cord-006229-7yoilsho	3259	4	proteins	protein	NNS
cord-006229-7yoilsho	3259	5	were	be	VBD
cord-006229-7yoilsho	3259	6	subjected	subject	VBN
cord-006229-7yoilsho	3259	7	to	to	IN
cord-006229-7yoilsho	3259	8	pathway	pathway	NN
cord-006229-7yoilsho	3259	9	analysis	analysis	NN
cord-006229-7yoilsho	3259	10	.	.	.
cord-006229-7yoilsho	3260	1	The	the	DT
cord-006229-7yoilsho	3260	2	data	datum	NNS
cord-006229-7yoilsho	3260	3	presented	present	VBN
cord-006229-7yoilsho	3260	4	might	may	MD
cord-006229-7yoilsho	3260	5	contribute	contribute	VB
cord-006229-7yoilsho	3260	6	to	to	IN
cord-006229-7yoilsho	3260	7	the	the	DT
cord-006229-7yoilsho	3260	8	further	further	JJ
cord-006229-7yoilsho	3260	9	development	development	NN
cord-006229-7yoilsho	3260	10	of	of	IN
cord-006229-7yoilsho	3260	11	suitable	suitable	JJ
cord-006229-7yoilsho	3260	12	in	in	IN
cord-006229-7yoilsho	3260	13	vitro	vitro	FW
cord-006229-7yoilsho	3260	14	testing	testing	NN
cord-006229-7yoilsho	3260	15	methods	method	NNS
cord-006229-7yoilsho	3260	16	for	for	IN
cord-006229-7yoilsho	3260	17	chemical	chemical	NN
cord-006229-7yoilsho	3260	18	-	-	HYPH
cord-006229-7yoilsho	3260	19	mediated	mediate	VBN
cord-006229-7yoilsho	3260	20	sensitization	sensitization	NN
cord-006229-7yoilsho	3260	21	.	.	.
cord-006229-7yoilsho	3261	1	Drug	drug	NN
cord-006229-7yoilsho	3261	2	induced	induce	VBN
cord-006229-7yoilsho	3261	3	Liver	Liver	NNP
cord-006229-7yoilsho	3261	4	Injury	injury	NN
cord-006229-7yoilsho	3261	5	(	(	-LRB-
cord-006229-7yoilsho	3261	6	DILI	DILI	NNP
cord-006229-7yoilsho	3261	7	)	)	-RRB-
cord-006229-7yoilsho	3262	1	is	be	VBZ
cord-006229-7yoilsho	3262	2	one	one	CD
cord-006229-7yoilsho	3262	3	of	of	IN
cord-006229-7yoilsho	3262	4	the	the	DT
cord-006229-7yoilsho	3262	5	most	most	RBS
cord-006229-7yoilsho	3262	6	frequent	frequent	JJ
cord-006229-7yoilsho	3262	7	causes	cause	NNS
cord-006229-7yoilsho	3262	8	of	of	IN
cord-006229-7yoilsho	3262	9	acute	acute	JJ
cord-006229-7yoilsho	3262	10	liver	liver	NN
cord-006229-7yoilsho	3262	11	injury	injury	NN
cord-006229-7yoilsho	3262	12	and	and	CC
cord-006229-7yoilsho	3262	13	a	a	DT
cord-006229-7yoilsho	3262	14	main	main	JJ
cord-006229-7yoilsho	3262	15	cause	cause	NN
cord-006229-7yoilsho	3262	16	for	for	IN
cord-006229-7yoilsho	3262	17	drug	drug	NN
cord-006229-7yoilsho	3262	18	withdrawals	withdrawal	NNS
cord-006229-7yoilsho	3262	19	.	.	.
cord-006229-7yoilsho	3263	1	Currently	currently	RB
cord-006229-7yoilsho	3263	2	there	there	EX
cord-006229-7yoilsho	3263	3	are	be	VBP
cord-006229-7yoilsho	3263	4	no	no	DT
cord-006229-7yoilsho	3263	5	reliable	reliable	JJ
cord-006229-7yoilsho	3263	6	models	model	NNS
cord-006229-7yoilsho	3263	7	to	to	TO
cord-006229-7yoilsho	3263	8	test	test	VB
cord-006229-7yoilsho	3263	9	the	the	DT
cord-006229-7yoilsho	3263	10	DILI	DILI	NNP
cord-006229-7yoilsho	3263	11	potential	potential	NN
cord-006229-7yoilsho	3263	12	of	of	IN
cord-006229-7yoilsho	3263	13	new	new	JJ
cord-006229-7yoilsho	3263	14	compounds	compound	NNS
cord-006229-7yoilsho	3263	15	available	available	JJ
cord-006229-7yoilsho	3263	16	.	.	.
cord-006229-7yoilsho	3264	1	Kupffer	Kupffer	NNP
cord-006229-7yoilsho	3264	2	cells	cell	NNS
cord-006229-7yoilsho	3264	3	(	(	-LRB-
cord-006229-7yoilsho	3264	4	KC	KC	NNP
cord-006229-7yoilsho	3264	5	)	)	-RRB-
cord-006229-7yoilsho	3264	6	play	play	VB
cord-006229-7yoilsho	3264	7	an	an	DT
cord-006229-7yoilsho	3264	8	important	important	JJ
cord-006229-7yoilsho	3264	9	role	role	NN
cord-006229-7yoilsho	3264	10	in	in	IN
cord-006229-7yoilsho	3264	11	hepatic	hepatic	JJ
cord-006229-7yoilsho	3264	12	cell	cell	NN
cord-006229-7yoilsho	3264	13	stress	stress	NN
cord-006229-7yoilsho	3264	14	mediated	mediate	VBN
cord-006229-7yoilsho	3264	15	through	through	IN
cord-006229-7yoilsho	3264	16	chemokines	chemokine	NNS
cord-006229-7yoilsho	3264	17	and	and	CC
cord-006229-7yoilsho	3264	18	release	release	NN
cord-006229-7yoilsho	3264	19	of	of	IN
cord-006229-7yoilsho	3264	20	endogenous	endogenous	JJ
cord-006229-7yoilsho	3264	21	proteins	protein	NNS
cord-006229-7yoilsho	3264	22	.	.	.
cord-006229-7yoilsho	3265	1	KC	KC	NNP
cord-006229-7yoilsho	3265	2	activation	activation	NN
cord-006229-7yoilsho	3265	3	by	by	IN
cord-006229-7yoilsho	3265	4	damaged	damage	VBN
cord-006229-7yoilsho	3265	5	or	or	CC
cord-006229-7yoilsho	3265	6	stressed	stress	VBN
cord-006229-7yoilsho	3265	7	hepatocytes	hepatocyte	NNS
cord-006229-7yoilsho	3265	8	can	can	MD
cord-006229-7yoilsho	3265	9	lead	lead	VB
cord-006229-7yoilsho	3265	10	to	to	IN
cord-006229-7yoilsho	3265	11	activation	activation	NN
cord-006229-7yoilsho	3265	12	of	of	IN
cord-006229-7yoilsho	3265	13	the	the	DT
cord-006229-7yoilsho	3265	14	NF	nf	NN
cord-006229-7yoilsho	3265	15	-	-	HYPH
cord-006229-7yoilsho	3265	16	κB	κB	NNP
cord-006229-7yoilsho	3265	17	signaling	signal	VBG
cord-006229-7yoilsho	3265	18	pathway	pathway	NN
cord-006229-7yoilsho	3265	19	transmitted	transmit	VBN
cord-006229-7yoilsho	3265	20	by	by	IN
cord-006229-7yoilsho	3265	21	reactive	reactive	JJ
cord-006229-7yoilsho	3265	22	oxygen	oxygen	NN
cord-006229-7yoilsho	3265	23	intermediates	intermediate	NNS
cord-006229-7yoilsho	3265	24	(	(	-LRB-
cord-006229-7yoilsho	3265	25	ROI	ROI	NNP
cord-006229-7yoilsho	3265	26	)	)	-RRB-
cord-006229-7yoilsho	3265	27	.	.	.
cord-006229-7yoilsho	3266	1	We	-PRON-	PRP
cord-006229-7yoilsho	3266	2	have	have	VBP
cord-006229-7yoilsho	3266	3	recently	recently	RB
cord-006229-7yoilsho	3266	4	established	establish	VBN
cord-006229-7yoilsho	3266	5	a	a	DT
cord-006229-7yoilsho	3266	6	liver	liver	NN
cord-006229-7yoilsho	3266	7	model	model	NN
cord-006229-7yoilsho	3266	8	composed	compose	VBN
cord-006229-7yoilsho	3266	9	of	of	IN
cord-006229-7yoilsho	3266	10	primary	primary	JJ
cord-006229-7yoilsho	3266	11	human	human	JJ
cord-006229-7yoilsho	3266	12	hepatocytes	hepatocyte	NNS
cord-006229-7yoilsho	3266	13	(	(	-LRB-
cord-006229-7yoilsho	3266	14	PHH	PHH	NNP
cord-006229-7yoilsho	3266	15	)	)	-RRB-
cord-006229-7yoilsho	3266	16	and	and	CC
cord-006229-7yoilsho	3266	17	KC	KC	NNP
cord-006229-7yoilsho	3266	18	which	which	WDT
cord-006229-7yoilsho	3266	19	enables	enable	VBZ
cord-006229-7yoilsho	3266	20	investigation	investigation	NN
cord-006229-7yoilsho	3266	21	of	of	IN
cord-006229-7yoilsho	3266	22	immune	immune	JJ
cord-006229-7yoilsho	3266	23	reactions	reaction	NNS
cord-006229-7yoilsho	3266	24	after	after	IN
cord-006229-7yoilsho	3266	25	induction	induction	NN
cord-006229-7yoilsho	3266	26	of	of	IN
cord-006229-7yoilsho	3266	27	hepatocyte	hepatocyte	NN
cord-006229-7yoilsho	3266	28	stress	stress	NN
cord-006229-7yoilsho	3266	29	(	(	-LRB-
cord-006229-7yoilsho	3266	30	Kegel	Kegel	NNP
cord-006229-7yoilsho	3266	31	et	et	NNP
cord-006229-7yoilsho	3266	32	al	al	NNP
cord-006229-7yoilsho	3266	33	.	.	NNP
cord-006229-7yoilsho	3266	34	,	,	,
cord-006229-7yoilsho	3266	35	2015	2015	CD
cord-006229-7yoilsho	3266	36	)	)	-RRB-
cord-006229-7yoilsho	3266	37	.	.	.
cord-006229-7yoilsho	3267	1	Aim	aim	VB
cord-006229-7yoilsho	3267	2	of	of	IN
cord-006229-7yoilsho	3267	3	the	the	DT
cord-006229-7yoilsho	3267	4	present	present	JJ
cord-006229-7yoilsho	3267	5	study	study	NN
cord-006229-7yoilsho	3267	6	was	be	VBD
cord-006229-7yoilsho	3267	7	the	the	DT
cord-006229-7yoilsho	3267	8	kinetic	kinetic	JJ
cord-006229-7yoilsho	3267	9	investigation	investigation	NN
cord-006229-7yoilsho	3267	10	of	of	IN
cord-006229-7yoilsho	3267	11	hepatic	hepatic	JJ
cord-006229-7yoilsho	3267	12	cell	cell	NN
cord-006229-7yoilsho	3267	13	stress	stress	NN
cord-006229-7yoilsho	3267	14	induction	induction	NN
cord-006229-7yoilsho	3267	15	and	and	CC
cord-006229-7yoilsho	3267	16	macrophage	macrophage	NN
cord-006229-7yoilsho	3267	17	activation	activation	NN
cord-006229-7yoilsho	3267	18	after	after	IN
cord-006229-7yoilsho	3267	19	treatment	treatment	NN
cord-006229-7yoilsho	3267	20	with	with	IN
cord-006229-7yoilsho	3267	21	subtoxic	subtoxic	JJ
cord-006229-7yoilsho	3267	22	concentrations	concentration	NNS
cord-006229-7yoilsho	3267	23	of	of	IN
cord-006229-7yoilsho	3267	24	hepatotoxic	hepatotoxic	JJ
cord-006229-7yoilsho	3267	25	drugs	drug	NNS
cord-006229-7yoilsho	3267	26	.	.	.
cord-006229-7yoilsho	3268	1	Primary	primary	JJ
cord-006229-7yoilsho	3268	2	human	human	JJ
cord-006229-7yoilsho	3268	3	hepatocytes	hepatocyte	NNS
cord-006229-7yoilsho	3268	4	(	(	-LRB-
cord-006229-7yoilsho	3268	5	PHH	PHH	NNP
cord-006229-7yoilsho	3268	6	)	)	-RRB-
cord-006229-7yoilsho	3268	7	and	and	CC
cord-006229-7yoilsho	3268	8	KC	KC	NNP
cord-006229-7yoilsho	3268	9	were	be	VBD
cord-006229-7yoilsho	3268	10	isolated	isolate	VBN
cord-006229-7yoilsho	3268	11	from	from	IN
cord-006229-7yoilsho	3268	12	human	human	JJ
cord-006229-7yoilsho	3268	13	liver	liver	NN
cord-006229-7yoilsho	3268	14	resectates	resectate	NNS
cord-006229-7yoilsho	3268	15	using	use	VBG
cord-006229-7yoilsho	3268	16	a	a	DT
cord-006229-7yoilsho	3268	17	two	two	CD
cord-006229-7yoilsho	3268	18	-	-	HYPH
cord-006229-7yoilsho	3268	19	step	step	NN
cord-006229-7yoilsho	3268	20	collagenase	collagenase	NN
cord-006229-7yoilsho	3268	21	perfusion	perfusion	NN
cord-006229-7yoilsho	3268	22	technique	technique	NN
cord-006229-7yoilsho	3268	23	.	.	.
cord-006229-7yoilsho	3269	1	Initial	initial	JJ
cord-006229-7yoilsho	3269	2	KC	KC	NNP
cord-006229-7yoilsho	3269	3	activation	activation	NN
cord-006229-7yoilsho	3269	4	was	be	VBD
cord-006229-7yoilsho	3269	5	characterized	characterize	VBN
cord-006229-7yoilsho	3269	6	by	by	IN
cord-006229-7yoilsho	3269	7	the	the	DT
cord-006229-7yoilsho	3269	8	DCF	DCF	NNP
cord-006229-7yoilsho	3269	9	assay	assay	NN
cord-006229-7yoilsho	3269	10	and	and	CC
cord-006229-7yoilsho	3269	11	immunofluorescence	immunofluorescence	NN
cord-006229-7yoilsho	3269	12	staining	staining	NN
cord-006229-7yoilsho	3269	13	.	.	.
cord-006229-7yoilsho	3270	1	PHH	PHH	NNP
cord-006229-7yoilsho	3270	2	were	be	VBD
cord-006229-7yoilsho	3270	3	incubated	incubate	VBN
cord-006229-7yoilsho	3270	4	with	with	IN
cord-006229-7yoilsho	3270	5	different	different	JJ
cord-006229-7yoilsho	3270	6	concentrations	concentration	NNS
cord-006229-7yoilsho	3270	7	of	of	IN
cord-006229-7yoilsho	3270	8	acetaminophen	acetaminophen	NN
cord-006229-7yoilsho	3270	9	(	(	-LRB-
cord-006229-7yoilsho	3270	10	APAP	APAP	NNP
cord-006229-7yoilsho	3270	11	)	)	-RRB-
cord-006229-7yoilsho	3270	12	and	and	CC
cord-006229-7yoilsho	3270	13	diclofenac	diclofenac	JJ
cord-006229-7yoilsho	3270	14	(	(	-LRB-
cord-006229-7yoilsho	3270	15	DIC	DIC	NNP
cord-006229-7yoilsho	3270	16	)	)	-RRB-
cord-006229-7yoilsho	3270	17	for	for	IN
cord-006229-7yoilsho	3270	18	different	different	JJ
cord-006229-7yoilsho	3270	19	time	time	NN
cord-006229-7yoilsho	3270	20	intervals	interval	NNS
cord-006229-7yoilsho	3270	21	.	.	.
cord-006229-7yoilsho	3271	1	Cell	cell	NN
cord-006229-7yoilsho	3271	2	stress	stress	NN
cord-006229-7yoilsho	3271	3	was	be	VBD
cord-006229-7yoilsho	3271	4	evaluated	evaluate	VBN
cord-006229-7yoilsho	3271	5	by	by	IN
cord-006229-7yoilsho	3271	6	measurement	measurement	NN
cord-006229-7yoilsho	3271	7	of	of	IN
cord-006229-7yoilsho	3271	8	oxidative	oxidative	JJ
cord-006229-7yoilsho	3271	9	stress	stress	NN
cord-006229-7yoilsho	3271	10	(	(	-LRB-
cord-006229-7yoilsho	3271	11	DCFassay	DCFassay	NNP
cord-006229-7yoilsho	3271	12	)	)	-RRB-
cord-006229-7yoilsho	3271	13	and	and	CC
cord-006229-7yoilsho	3271	14	viability	viability	NN
cord-006229-7yoilsho	3271	15	(	(	-LRB-
cord-006229-7yoilsho	3271	16	XTT	XTT	NNP
cord-006229-7yoilsho	3271	17	-	-	HYPH
cord-006229-7yoilsho	3271	18	assay	assay	NN
cord-006229-7yoilsho	3271	19	)	)	-RRB-
cord-006229-7yoilsho	3271	20	.	.	.
cord-006229-7yoilsho	3272	1	In	in	IN
cord-006229-7yoilsho	3272	2	order	order	NN
cord-006229-7yoilsho	3272	3	to	to	TO
cord-006229-7yoilsho	3272	4	simulate	simulate	VB
cord-006229-7yoilsho	3272	5	macrophage	macrophage	NN
cord-006229-7yoilsho	3272	6	activation	activation	NN
cord-006229-7yoilsho	3272	7	following	follow	VBG
cord-006229-7yoilsho	3272	8	hepatocyte	hepatocyte	NN
cord-006229-7yoilsho	3272	9	damage	damage	NN
cord-006229-7yoilsho	3272	10	,	,	,
cord-006229-7yoilsho	3272	11	KC	KC	NNP
cord-006229-7yoilsho	3272	12	and	and	CC
cord-006229-7yoilsho	3272	13	macrophages	macrophage	NNS
cord-006229-7yoilsho	3272	14	derived	derive	VBN
cord-006229-7yoilsho	3272	15	from	from	IN
cord-006229-7yoilsho	3272	16	the	the	DT
cord-006229-7yoilsho	3272	17	monocytic	monocytic	JJ
cord-006229-7yoilsho	3272	18	cell	cell	NN
cord-006229-7yoilsho	3272	19	line	line	NN
cord-006229-7yoilsho	3272	20	THP-1	THP-1	NNP
cord-006229-7yoilsho	3272	21	were	be	VBD
cord-006229-7yoilsho	3272	22	incubated	incubate	VBN
cord-006229-7yoilsho	3272	23	with	with	IN
cord-006229-7yoilsho	3272	24	supernatants	supernatant	NNS
cord-006229-7yoilsho	3272	25	of	of	IN
cord-006229-7yoilsho	3272	26	PHH	PHH	NNP
cord-006229-7yoilsho	3272	27	treated	treat	VBN
cord-006229-7yoilsho	3272	28	with	with	IN
cord-006229-7yoilsho	3272	29	hepatotoxic	hepatotoxic	JJ
cord-006229-7yoilsho	3272	30	compounds	compound	NNS
cord-006229-7yoilsho	3272	31	.	.	.
cord-006229-7yoilsho	3273	1	KC	KC	NNP
cord-006229-7yoilsho	3273	2	and	and	CC
cord-006229-7yoilsho	3273	3	THP-1-macrophage	thp-1-macrophage	NN
cord-006229-7yoilsho	3273	4	activation	activation	NN
cord-006229-7yoilsho	3273	5	were	be	VBD
cord-006229-7yoilsho	3273	6	investigated	investigate	VBN
cord-006229-7yoilsho	3273	7	by	by	IN
cord-006229-7yoilsho	3273	8	measuring	measure	VBG
cord-006229-7yoilsho	3273	9	intracellular	intracellular	JJ
cord-006229-7yoilsho	3273	10	formation	formation	NN
cord-006229-7yoilsho	3273	11	of	of	IN
cord-006229-7yoilsho	3273	12	ROI	ROI	NNP
cord-006229-7yoilsho	3273	13	using	use	VBG
cord-006229-7yoilsho	3273	14	the	the	DT
cord-006229-7yoilsho	3273	15	DCF	DCF	NNP
cord-006229-7yoilsho	3273	16	-	-	HYPH
cord-006229-7yoilsho	3273	17	assay	assay	NN
cord-006229-7yoilsho	3273	18	and	and	CC
cord-006229-7yoilsho	3273	19	cell	cell	NN
cord-006229-7yoilsho	3273	20	activity	activity	NN
cord-006229-7yoilsho	3273	21	using	use	VBG
cord-006229-7yoilsho	3273	22	the	the	DT
cord-006229-7yoilsho	3273	23	XTT	XTT	NNP
cord-006229-7yoilsho	3273	24	-	-	HYPH
cord-006229-7yoilsho	3273	25	assay	assay	NN
cord-006229-7yoilsho	3273	26	.	.	.
cord-006229-7yoilsho	3274	1	The	the	DT
cord-006229-7yoilsho	3274	2	characterization	characterization	NN
cord-006229-7yoilsho	3274	3	of	of	IN
cord-006229-7yoilsho	3274	4	KC	KC	NNP
cord-006229-7yoilsho	3274	5	activation	activation	NN
cord-006229-7yoilsho	3274	6	revealed	reveal	VBD
cord-006229-7yoilsho	3274	7	a	a	DT
cord-006229-7yoilsho	3274	8	donor	donor	NN
cord-006229-7yoilsho	3274	9	and	and	CC
cord-006229-7yoilsho	3274	10	disease	disease	NN
cord-006229-7yoilsho	3274	11	dependent	dependent	JJ
cord-006229-7yoilsho	3274	12	KC	KC	NNP
cord-006229-7yoilsho	3274	13	activation	activation	NN
cord-006229-7yoilsho	3274	14	resulting	result	VBG
cord-006229-7yoilsho	3274	15	in	in	IN
cord-006229-7yoilsho	3274	16	KC	KC	NNP
cord-006229-7yoilsho	3274	17	differentiation	differentiation	NN
cord-006229-7yoilsho	3274	18	to	to	IN
cord-006229-7yoilsho	3274	19	pro	pro	JJ
cord-006229-7yoilsho	3274	20	-	-	JJ
cord-006229-7yoilsho	3274	21	and	and	CC
cord-006229-7yoilsho	3274	22	anti	anti	JJ
cord-006229-7yoilsho	3274	23	-	-	JJ
cord-006229-7yoilsho	3274	24	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	3274	25	macrophages	macrophage	NNS
cord-006229-7yoilsho	3274	26	.	.	.
cord-006229-7yoilsho	3275	1	Therefore	therefore	RB
cord-006229-7yoilsho	3275	2	,	,	,
cord-006229-7yoilsho	3275	3	KC	KC	NNP
cord-006229-7yoilsho	3275	4	were	be	VBD
cord-006229-7yoilsho	3275	5	substituted	substitute	VBN
cord-006229-7yoilsho	3275	6	by	by	IN
cord-006229-7yoilsho	3275	7	macrophages	macrophage	NNS
cord-006229-7yoilsho	3275	8	derived	derive	VBN
cord-006229-7yoilsho	3275	9	from	from	IN
cord-006229-7yoilsho	3275	10	THP-1	THP-1	NNP
cord-006229-7yoilsho	3275	11	cells	cell	NNS
cord-006229-7yoilsho	3275	12	.	.	.
cord-006229-7yoilsho	3276	1	Evaluation	evaluation	NN
cord-006229-7yoilsho	3276	2	of	of	IN
cord-006229-7yoilsho	3276	3	hepatic	hepatic	JJ
cord-006229-7yoilsho	3276	4	cell	cell	NN
cord-006229-7yoilsho	3276	5	stress	stress	NN
cord-006229-7yoilsho	3276	6	showed	show	VBD
cord-006229-7yoilsho	3276	7	the	the	DT
cord-006229-7yoilsho	3276	8	strongest	strong	JJS
cord-006229-7yoilsho	3276	9	effect	effect	NN
cord-006229-7yoilsho	3276	10	on	on	IN
cord-006229-7yoilsho	3276	11	THP-1-macrophages	thp-1-macrophage	NNS
cord-006229-7yoilsho	3276	12	when	when	WRB
cord-006229-7yoilsho	3276	13	PHH	PHH	NNP
cord-006229-7yoilsho	3276	14	were	be	VBD
cord-006229-7yoilsho	3276	15	incubated	incubate	VBN
cord-006229-7yoilsho	3276	16	with	with	IN
cord-006229-7yoilsho	3276	17	APAP	APAP	NNP
cord-006229-7yoilsho	3276	18	or	or	CC
cord-006229-7yoilsho	3276	19	DIC	DIC	NNP
cord-006229-7yoilsho	3276	20	for	for	IN
cord-006229-7yoilsho	3276	21	4	4	CD
cord-006229-7yoilsho	3276	22	h.	h.	NN
cord-006229-7yoilsho	3277	1	Treatment	treatment	NN
cord-006229-7yoilsho	3277	2	of	of	IN
cord-006229-7yoilsho	3277	3	KC	KC	NNP
cord-006229-7yoilsho	3277	4	and	and	CC
cord-006229-7yoilsho	3277	5	THP-1-macrophages	thp-1-macrophage	NNS
cord-006229-7yoilsho	3277	6	with	with	IN
cord-006229-7yoilsho	3277	7	supernatants	supernatant	NNS
cord-006229-7yoilsho	3277	8	of	of	IN
cord-006229-7yoilsho	3277	9	PHH	PHH	NNP
cord-006229-7yoilsho	3277	10	challenged	challenge	VBD
cord-006229-7yoilsho	3277	11	for	for	IN
cord-006229-7yoilsho	3277	12	4	4	CD
cord-006229-7yoilsho	3277	13	h	h	NN
cord-006229-7yoilsho	3277	14	with	with	IN
cord-006229-7yoilsho	3277	15	hepatotoxic	hepatotoxic	JJ
cord-006229-7yoilsho	3277	16	compounds	compound	NNS
cord-006229-7yoilsho	3278	1	indicates	indicate	VBZ
cord-006229-7yoilsho	3278	2	that	that	IN
cord-006229-7yoilsho	3278	3	THP-1-derived	thp-1-derive	VBN
cord-006229-7yoilsho	3278	4	macrophages	macrophage	NNS
cord-006229-7yoilsho	3278	5	react	react	VBP
cord-006229-7yoilsho	3278	6	similar	similar	JJ
cord-006229-7yoilsho	3278	7	to	to	IN
cord-006229-7yoilsho	3278	8	KC	KC	NNP
cord-006229-7yoilsho	3278	9	when	when	WRB
cord-006229-7yoilsho	3278	10	treated	treat	VBN
cord-006229-7yoilsho	3278	11	with	with	IN
cord-006229-7yoilsho	3278	12	PHH	PHH	NNP
cord-006229-7yoilsho	3278	13	supernatants	supernatant	NNS
cord-006229-7yoilsho	3278	14	in	in	IN
cord-006229-7yoilsho	3278	15	terms	term	NNS
cord-006229-7yoilsho	3278	16	of	of	IN
cord-006229-7yoilsho	3278	17	cell	cell	NN
cord-006229-7yoilsho	3278	18	activity	activity	NN
cord-006229-7yoilsho	3278	19	and	and	CC
cord-006229-7yoilsho	3278	20	ROI	roi	NN
cord-006229-7yoilsho	3278	21	-	-	HYPH
cord-006229-7yoilsho	3278	22	production	production	NN
cord-006229-7yoilsho	3278	23	.	.	.
cord-006229-7yoilsho	3279	1	In	in	IN
cord-006229-7yoilsho	3279	2	conclusion	conclusion	NN
cord-006229-7yoilsho	3279	3	,	,	,
cord-006229-7yoilsho	3279	4	THP-1	THP-1	NNP
cord-006229-7yoilsho	3279	5	derived	derive	VBD
cord-006229-7yoilsho	3279	6	macrophages	macrophage	NNS
cord-006229-7yoilsho	3279	7	might	may	MD
cord-006229-7yoilsho	3279	8	be	be	VB
cord-006229-7yoilsho	3279	9	a	a	DT
cord-006229-7yoilsho	3279	10	suitable	suitable	JJ
cord-006229-7yoilsho	3279	11	alternative	alternative	NN
cord-006229-7yoilsho	3279	12	to	to	IN
cord-006229-7yoilsho	3279	13	KC	KC	NNP
cord-006229-7yoilsho	3279	14	concerning	concern	VBG
cord-006229-7yoilsho	3279	15	macrophage	macrophage	NN
cord-006229-7yoilsho	3279	16	activation	activation	NN
cord-006229-7yoilsho	3279	17	.	.	.
cord-006229-7yoilsho	3280	1	The	the	DT
cord-006229-7yoilsho	3280	2	evaluated	evaluate	VBN
cord-006229-7yoilsho	3280	3	kinetic	kinetic	JJ
cord-006229-7yoilsho	3280	4	window	window	NN
cord-006229-7yoilsho	3280	5	of	of	IN
cord-006229-7yoilsho	3280	6	4	4	CD
cord-006229-7yoilsho	3280	7	h	h	NN
cord-006229-7yoilsho	3280	8	covering	cover	VBG
cord-006229-7yoilsho	3280	9	hepatic	hepatic	JJ
cord-006229-7yoilsho	3280	10	stress	stress	NN
cord-006229-7yoilsho	3280	11	induction	induction	NN
cord-006229-7yoilsho	3280	12	and	and	CC
cord-006229-7yoilsho	3280	13	immune	immune	JJ
cord-006229-7yoilsho	3280	14	reaction	reaction	NN
cord-006229-7yoilsho	3280	15	allows	allow	VBZ
cord-006229-7yoilsho	3280	16	to	to	TO
cord-006229-7yoilsho	3280	17	perform	perform	VB
cord-006229-7yoilsho	3280	18	these	these	DT
cord-006229-7yoilsho	3280	19	measurements	measurement	NNS
cord-006229-7yoilsho	3280	20	in	in	IN
cord-006229-7yoilsho	3280	21	a	a	DT
cord-006229-7yoilsho	3280	22	Since	since	IN
cord-006229-7yoilsho	3280	23	the	the	DT
cord-006229-7yoilsho	3280	24	use	use	NN
cord-006229-7yoilsho	3280	25	of	of	IN
cord-006229-7yoilsho	3280	26	cerium	cerium	NN
cord-006229-7yoilsho	3280	27	dioxide	dioxide	NN
cord-006229-7yoilsho	3280	28	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	3280	29	is	be	VBZ
cord-006229-7yoilsho	3280	30	known	know	VBN
cord-006229-7yoilsho	3280	31	to	to	TO
cord-006229-7yoilsho	3280	32	be	be	VB
cord-006229-7yoilsho	3280	33	beneficial	beneficial	JJ
cord-006229-7yoilsho	3280	34	e.g.	e.g.	RB
cord-006229-7yoilsho	3280	35	in	in	IN
cord-006229-7yoilsho	3280	36	terms	term	NNS
cord-006229-7yoilsho	3280	37	of	of	IN
cord-006229-7yoilsho	3280	38	reducing	reduce	VBG
cord-006229-7yoilsho	3280	39	fuel	fuel	NN
cord-006229-7yoilsho	3280	40	consumption	consumption	NN
cord-006229-7yoilsho	3280	41	when	when	WRB
cord-006229-7yoilsho	3280	42	added	add	VBN
cord-006229-7yoilsho	3280	43	to	to	TO
cord-006229-7yoilsho	3280	44	diesel	diesel	VB
cord-006229-7yoilsho	3280	45	fuel	fuel	NN
cord-006229-7yoilsho	3281	1	it	-PRON-	PRP
cord-006229-7yoilsho	3281	2	has	have	VBZ
cord-006229-7yoilsho	3281	3	become	become	VBN
cord-006229-7yoilsho	3281	4	a	a	DT
cord-006229-7yoilsho	3281	5	frequently	frequently	RB
cord-006229-7yoilsho	3281	6	used	use	VBN
cord-006229-7yoilsho	3281	7	nanomaterial	nanomaterial	NN
cord-006229-7yoilsho	3281	8	.	.	.
cord-006229-7yoilsho	3282	1	To	to	TO
cord-006229-7yoilsho	3282	2	compensate	compensate	VB
cord-006229-7yoilsho	3282	3	the	the	DT
cord-006229-7yoilsho	3282	4	concurrent	concurrent	JJ
cord-006229-7yoilsho	3282	5	lack	lack	NN
cord-006229-7yoilsho	3282	6	of	of	IN
cord-006229-7yoilsho	3282	7	information	information	NN
cord-006229-7yoilsho	3282	8	on	on	IN
cord-006229-7yoilsho	3282	9	its	-PRON-	PRP$
cord-006229-7yoilsho	3282	10	toxicology	toxicology	NN
cord-006229-7yoilsho	3282	11	a	a	DT
cord-006229-7yoilsho	3282	12	90day	90day	JJ
cord-006229-7yoilsho	3282	13	nose	nose	NN
cord-006229-7yoilsho	3282	14	-	-	HYPH
cord-006229-7yoilsho	3282	15	only	only	RB
cord-006229-7yoilsho	3282	16	inhalation	inhalation	NN
cord-006229-7yoilsho	3282	17	study	study	NN
cord-006229-7yoilsho	3282	18	was	be	VBD
cord-006229-7yoilsho	3282	19	initiated	initiate	VBN
cord-006229-7yoilsho	3282	20	.	.	.
cord-006229-7yoilsho	3283	1	By	by	IN
cord-006229-7yoilsho	3283	2	comparing	compare	VBG
cord-006229-7yoilsho	3283	3	the	the	DT
cord-006229-7yoilsho	3283	4	results	result	NNS
cord-006229-7yoilsho	3283	5	to	to	IN
cord-006229-7yoilsho	3283	6	a	a	DT
cord-006229-7yoilsho	3283	7	combined	combine	VBN
cord-006229-7yoilsho	3283	8	chronic	chronic	JJ
cord-006229-7yoilsho	3283	9	inhalation	inhalation	NN
cord-006229-7yoilsho	3283	10	toxicity	toxicity	NN
cord-006229-7yoilsho	3283	11	and	and	CC
cord-006229-7yoilsho	3283	12	carcinogenicity	carcinogenicity	NN
cord-006229-7yoilsho	3283	13	study	study	NN
cord-006229-7yoilsho	3283	14	using	use	VBG
cord-006229-7yoilsho	3283	15	the	the	DT
cord-006229-7yoilsho	3283	16	same	same	JJ
cord-006229-7yoilsho	3283	17	test	test	NN
cord-006229-7yoilsho	3283	18	items	item	NNS
cord-006229-7yoilsho	3283	19	and	and	CC
cord-006229-7yoilsho	3283	20	experimental	experimental	JJ
cord-006229-7yoilsho	3283	21	conditions	condition	NNS
cord-006229-7yoilsho	3283	22	(	(	-LRB-
cord-006229-7yoilsho	3283	23	BASF	BASF	NNP
cord-006229-7yoilsho	3283	24	,	,	,
cord-006229-7yoilsho	3283	25	Ludwigshafen	Ludwigshafen	NNP
cord-006229-7yoilsho	3283	26	,	,	,
cord-006229-7yoilsho	3283	27	Germany	Germany	NNP
cord-006229-7yoilsho	3283	28	)	)	-RRB-
cord-006229-7yoilsho	3283	29	early	early	JJ
cord-006229-7yoilsho	3283	30	indicators	indicator	NNS
cord-006229-7yoilsho	3283	31	for	for	IN
cord-006229-7yoilsho	3283	32	genotoxic	genotoxic	JJ
cord-006229-7yoilsho	3283	33	and	and	CC
cord-006229-7yoilsho	3283	34	carcinogenic	carcinogenic	JJ
cord-006229-7yoilsho	3283	35	effects	effect	NNS
cord-006229-7yoilsho	3283	36	should	should	MD
cord-006229-7yoilsho	3283	37	be	be	VB
cord-006229-7yoilsho	3283	38	determined	determine	VBN
cord-006229-7yoilsho	3283	39	.	.	.
cord-006229-7yoilsho	3284	1	Rats	rat	NNS
cord-006229-7yoilsho	3284	2	were	be	VBD
cord-006229-7yoilsho	3284	3	exposed	expose	VBN
cord-006229-7yoilsho	3284	4	to	to	IN
cord-006229-7yoilsho	3284	5	0	0	CD
cord-006229-7yoilsho	3284	6	,	,	,
cord-006229-7yoilsho	3284	7	0.1	0.1	CD
cord-006229-7yoilsho	3284	8	,	,	,
cord-006229-7yoilsho	3284	9	0.3	0.3	CD
cord-006229-7yoilsho	3284	10	,	,	,
cord-006229-7yoilsho	3284	11	1	1	CD
cord-006229-7yoilsho	3284	12	and	and	CC
cord-006229-7yoilsho	3284	13	3	3	CD
cord-006229-7yoilsho	3284	14	mg	mg	NNP
cord-006229-7yoilsho	3284	15	/	/	SYM
cord-006229-7yoilsho	3284	16	cm³	cm³	NN
cord-006229-7yoilsho	3284	17	CeO	ceo	NN
cord-006229-7yoilsho	3284	18	2	2	CD
cord-006229-7yoilsho	3284	19	as	as	RB
cord-006229-7yoilsho	3284	20	well	well	RB
cord-006229-7yoilsho	3284	21	as	as	IN
cord-006229-7yoilsho	3284	22	50	50	CD
cord-006229-7yoilsho	3284	23	mg	mg	NNP
cord-006229-7yoilsho	3284	24	/	/	SYM
cord-006229-7yoilsho	3284	25	m³	m³	NNP
cord-006229-7yoilsho	3284	26	BaSO	BaSO	NNP
cord-006229-7yoilsho	3284	27	4	4	CD
cord-006229-7yoilsho	3284	28	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	3284	29	(	(	-LRB-
cord-006229-7yoilsho	3284	30	6	6	CD
cord-006229-7yoilsho	3284	31	h	h	NN
cord-006229-7yoilsho	3284	32	/	/	SYM
cord-006229-7yoilsho	3284	33	day	day	NN
cord-006229-7yoilsho	3284	34	,	,	,
cord-006229-7yoilsho	3284	35	5	5	CD
cord-006229-7yoilsho	3284	36	days	day	NNS
cord-006229-7yoilsho	3284	37	/	/	SYM
cord-006229-7yoilsho	3284	38	week	week	NN
cord-006229-7yoilsho	3284	39	,	,	,
cord-006229-7yoilsho	3284	40	13	13	CD
cord-006229-7yoilsho	3284	41	weeks	week	NNS
cord-006229-7yoilsho	3284	42	)	)	-RRB-
cord-006229-7yoilsho	3284	43	.	.	.
cord-006229-7yoilsho	3285	1	Animal	animal	NN
cord-006229-7yoilsho	3285	2	dissections	dissection	NNS
cord-006229-7yoilsho	3285	3	were	be	VBD
cord-006229-7yoilsho	3285	4	conducted	conduct	VBN
cord-006229-7yoilsho	3285	5	at	at	IN
cord-006229-7yoilsho	3285	6	five	five	CD
cord-006229-7yoilsho	3285	7	time	time	NN
cord-006229-7yoilsho	3285	8	points	point	NNS
cord-006229-7yoilsho	3285	9	(	(	-LRB-
cord-006229-7yoilsho	3285	10	exposure	exposure	NN
cord-006229-7yoilsho	3285	11	day	day	NN
cord-006229-7yoilsho	3285	12	1	1	CD
cord-006229-7yoilsho	3285	13	and	and	CC
cord-006229-7yoilsho	3285	14	28	28	CD
cord-006229-7yoilsho	3285	15	;	;	:
cord-006229-7yoilsho	3285	16	recovery	recovery	NNP
cord-006229-7yoilsho	3285	17	day	day	NN
cord-006229-7yoilsho	3285	18	1	1	CD
cord-006229-7yoilsho	3285	19	,	,	,
cord-006229-7yoilsho	3285	20	28	28	CD
cord-006229-7yoilsho	3285	21	and	and	CC
cord-006229-7yoilsho	3285	22	90	90	CD
cord-006229-7yoilsho	3285	23	)	)	-RRB-
cord-006229-7yoilsho	3285	24	aiming	aim	VBG
cord-006229-7yoilsho	3285	25	for	for	IN
cord-006229-7yoilsho	3285	26	endpoints	endpoint	NNS
cord-006229-7yoilsho	3285	27	mandatory	mandatory	JJ
cord-006229-7yoilsho	3285	28	according	accord	VBG
cord-006229-7yoilsho	3285	29	to	to	IN
cord-006229-7yoilsho	3285	30	OECD	OECD	NNP
cord-006229-7yoilsho	3285	31	guideline	guideline	NN
cord-006229-7yoilsho	3285	32	413	413	CD
cord-006229-7yoilsho	3285	33	.	.	.
cord-006229-7yoilsho	3286	1	Additionally	additionally	RB
cord-006229-7yoilsho	3286	2	,	,	,
cord-006229-7yoilsho	3286	3	gene	gene	NN
cord-006229-7yoilsho	3286	4	expression	expression	NN
cord-006229-7yoilsho	3286	5	analyses	analysis	NNS
cord-006229-7yoilsho	3286	6	in	in	IN
cord-006229-7yoilsho	3286	7	isolated	isolated	JJ
cord-006229-7yoilsho	3286	8	pneumocytes	pneumocyte	NNS
cord-006229-7yoilsho	3286	9	type	type	NN
cord-006229-7yoilsho	3286	10	II	II	NNP
cord-006229-7yoilsho	3286	11	were	be	VBD
cord-006229-7yoilsho	3286	12	performed	perform	VBN
cord-006229-7yoilsho	3286	13	using	use	VBG
cord-006229-7yoilsho	3286	14	Pathway	Pathway	NNP
cord-006229-7yoilsho	3286	15	Arrays	Arrays	NNP
cord-006229-7yoilsho	3286	16	for	for	IN
cord-006229-7yoilsho	3286	17	inflammation	inflammation	NN
cord-006229-7yoilsho	3286	18	,	,	,
cord-006229-7yoilsho	3286	19	oxidative	oxidative	JJ
cord-006229-7yoilsho	3286	20	stress	stress	NN
cord-006229-7yoilsho	3286	21	,	,	,
cord-006229-7yoilsho	3286	22	genotoxicity	genotoxicity	NN
cord-006229-7yoilsho	3286	23	,	,	,
cord-006229-7yoilsho	3286	24	apoptosis	apoptosis	NN
cord-006229-7yoilsho	3286	25	and	and	CC
cord-006229-7yoilsho	3286	26	lung	lung	NN
cord-006229-7yoilsho	3286	27	cancer	cancer	NN
cord-006229-7yoilsho	3286	28	.	.	.
cord-006229-7yoilsho	3287	1	The	the	DT
cord-006229-7yoilsho	3287	2	given	give	VBN
cord-006229-7yoilsho	3287	3	results	result	NNS
cord-006229-7yoilsho	3287	4	intend	intend	VBP
cord-006229-7yoilsho	3287	5	the	the	DT
cord-006229-7yoilsho	3287	6	identification	identification	NN
cord-006229-7yoilsho	3287	7	of	of	IN
cord-006229-7yoilsho	3287	8	marker	marker	NN
cord-006229-7yoilsho	3287	9	genes	gene	NNS
cord-006229-7yoilsho	3287	10	displaying	display	VBG
cord-006229-7yoilsho	3287	11	modulated	modulate	VBN
cord-006229-7yoilsho	3287	12	expression	expression	NN
cord-006229-7yoilsho	3287	13	in	in	IN
cord-006229-7yoilsho	3287	14	response	response	NN
cord-006229-7yoilsho	3287	15	to	to	IN
cord-006229-7yoilsho	3287	16	nanoparticle	nanoparticle	NN
cord-006229-7yoilsho	3287	17	exposure	exposure	NN
cord-006229-7yoilsho	3287	18	.	.	.
cord-006229-7yoilsho	3288	1	Investigations	investigation	NNS
cord-006229-7yoilsho	3288	2	on	on	IN
cord-006229-7yoilsho	3288	3	CeO	CeO	NNP
cord-006229-7yoilsho	3288	4	2	2	CD
cord-006229-7yoilsho	3288	5	and	and	CC
cord-006229-7yoilsho	3288	6	BaSO	BaSO	NNP
cord-006229-7yoilsho	3288	7	4	4	CD
cord-006229-7yoilsho	3288	8	retention	retention	NN
cord-006229-7yoilsho	3288	9	in	in	IN
cord-006229-7yoilsho	3288	10	the	the	DT
cord-006229-7yoilsho	3288	11	lung	lung	NN
cord-006229-7yoilsho	3288	12	are	be	VBP
cord-006229-7yoilsho	3288	13	also	also	RB
cord-006229-7yoilsho	3288	14	included	include	VBN
cord-006229-7yoilsho	3288	15	in	in	IN
cord-006229-7yoilsho	3288	16	this	this	DT
cord-006229-7yoilsho	3288	17	project	project	NN
cord-006229-7yoilsho	3288	18	.	.	.
cord-006229-7yoilsho	3289	1	In	in	IN
cord-006229-7yoilsho	3289	2	bronchoalveolar	bronchoalveolar	NNP
cord-006229-7yoilsho	3289	3	lavage	lavage	NN
cord-006229-7yoilsho	3289	4	fluid	fluid	NN
cord-006229-7yoilsho	3289	5	(	(	-LRB-
cord-006229-7yoilsho	3289	6	BALF	BALF	NNP
cord-006229-7yoilsho	3289	7	)	)	-RRB-
cord-006229-7yoilsho	3289	8	a	a	DT
cord-006229-7yoilsho	3289	9	time	time	NN
cord-006229-7yoilsho	3289	10	and	and	CC
cord-006229-7yoilsho	3289	11	dose	dose	NN
cord-006229-7yoilsho	3289	12	-	-	HYPH
cord-006229-7yoilsho	3289	13	dependent	dependent	JJ
cord-006229-7yoilsho	3289	14	increase	increase	NN
cord-006229-7yoilsho	3289	15	of	of	IN
cord-006229-7yoilsho	3289	16	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	3289	17	cells	cell	NNS
cord-006229-7yoilsho	3289	18	has	have	VBZ
cord-006229-7yoilsho	3289	19	been	be	VBN
cord-006229-7yoilsho	3289	20	detected	detect	VBN
cord-006229-7yoilsho	3289	21	up	up	RP
cord-006229-7yoilsho	3289	22	to	to	IN
cord-006229-7yoilsho	3289	23	the	the	DT
cord-006229-7yoilsho	3289	24	end	end	NN
cord-006229-7yoilsho	3289	25	of	of	IN
cord-006229-7yoilsho	3289	26	exposure	exposure	NN
cord-006229-7yoilsho	3289	27	.	.	.
cord-006229-7yoilsho	3290	1	The	the	DT
cord-006229-7yoilsho	3290	2	amount	amount	NN
cord-006229-7yoilsho	3290	3	of	of	IN
cord-006229-7yoilsho	3290	4	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	3290	5	cells	cell	NNS
cord-006229-7yoilsho	3290	6	decreased	decrease	VBD
cord-006229-7yoilsho	3290	7	during	during	IN
cord-006229-7yoilsho	3290	8	post	post	JJ
cord-006229-7yoilsho	3290	9	-	-	JJ
cord-006229-7yoilsho	3290	10	exposure	exposure	NN
cord-006229-7yoilsho	3290	11	;	;	:
cord-006229-7yoilsho	3290	12	however	however	RB
cord-006229-7yoilsho	3290	13	,	,	,
cord-006229-7yoilsho	3290	14	in	in	IN
cord-006229-7yoilsho	3290	15	the	the	DT
cord-006229-7yoilsho	3290	16	high	high	JJ
cord-006229-7yoilsho	3290	17	dose	dose	NN
cord-006229-7yoilsho	3290	18	group	group	NN
cord-006229-7yoilsho	3290	19	a	a	DT
cord-006229-7yoilsho	3290	20	persistent	persistent	JJ
cord-006229-7yoilsho	3290	21	inflammation	inflammation	NN
cord-006229-7yoilsho	3290	22	up	up	IN
cord-006229-7yoilsho	3290	23	to	to	TO
cord-006229-7yoilsho	3290	24	90	90	CD
cord-006229-7yoilsho	3290	25	days	day	NNS
cord-006229-7yoilsho	3290	26	was	be	VBD
cord-006229-7yoilsho	3290	27	detected	detect	VBN
cord-006229-7yoilsho	3290	28	by	by	IN
cord-006229-7yoilsho	3290	29	BALF	BALF	NNP
cord-006229-7yoilsho	3290	30	and	and	CC
cord-006229-7yoilsho	3290	31	histopathology	histopathology	NN
cord-006229-7yoilsho	3290	32	examination	examination	NN
cord-006229-7yoilsho	3290	33	.	.	.
cord-006229-7yoilsho	3291	1	Based	base	VBN
cord-006229-7yoilsho	3291	2	on	on	IN
cord-006229-7yoilsho	3291	3	our	-PRON-	PRP$
cord-006229-7yoilsho	3291	4	current	current	JJ
cord-006229-7yoilsho	3291	5	results	result	NNS
cord-006229-7yoilsho	3291	6	effects	effect	NNS
cord-006229-7yoilsho	3291	7	of	of	IN
cord-006229-7yoilsho	3291	8	CeO	ceo	NN
cord-006229-7yoilsho	3291	9	2	2	CD
cord-006229-7yoilsho	3291	10	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	3291	11	on	on	IN
cord-006229-7yoilsho	3291	12	the	the	DT
cord-006229-7yoilsho	3291	13	respiratory	respiratory	JJ
cord-006229-7yoilsho	3291	14	system	system	NN
cord-006229-7yoilsho	3291	15	are	be	VBP
cord-006229-7yoilsho	3291	16	suggested	suggest	VBN
cord-006229-7yoilsho	3291	17	.	.	.
cord-006229-7yoilsho	3292	1	Its	-PRON-	PRP$
cord-006229-7yoilsho	3292	2	relevance	relevance	NN
cord-006229-7yoilsho	3292	3	in	in	IN
cord-006229-7yoilsho	3292	4	the	the	DT
cord-006229-7yoilsho	3292	5	context	context	NN
cord-006229-7yoilsho	3292	6	of	of	IN
cord-006229-7yoilsho	3292	7	long	long	JJ
cord-006229-7yoilsho	3292	8	term	term	NN
cord-006229-7yoilsho	3292	9	effects	effect	NNS
cord-006229-7yoilsho	3292	10	such	such	JJ
cord-006229-7yoilsho	3292	11	as	as	IN
cord-006229-7yoilsho	3292	12	tumor	tumor	NN
cord-006229-7yoilsho	3292	13	development	development	NN
cord-006229-7yoilsho	3292	14	needs	need	VBZ
cord-006229-7yoilsho	3292	15	to	to	TO
cord-006229-7yoilsho	3292	16	be	be	VB
cord-006229-7yoilsho	3292	17	estimated	estimate	VBN
cord-006229-7yoilsho	3292	18	considering	consider	VBG
cord-006229-7yoilsho	3292	19	all	all	DT
cord-006229-7yoilsho	3292	20	investigations	investigation	NNS
cord-006229-7yoilsho	3292	21	included	include	VBN
cord-006229-7yoilsho	3292	22	in	in	IN
cord-006229-7yoilsho	3292	23	this	this	DT
cord-006229-7yoilsho	3292	24	study	study	NN
cord-006229-7yoilsho	3292	25	.	.	.
cord-006229-7yoilsho	3293	1	The	the	DT
cord-006229-7yoilsho	3293	2	InhalT-90	inhalt-90	NN
cord-006229-7yoilsho	3293	3	project	project	NN
cord-006229-7yoilsho	3293	4	is	be	VBZ
cord-006229-7yoilsho	3293	5	funded	fund	VBN
cord-006229-7yoilsho	3293	6	by	by	IN
cord-006229-7yoilsho	3293	7	the	the	DT
cord-006229-7yoilsho	3293	8	German	German	NNP
cord-006229-7yoilsho	3293	9	Federal	Federal	NNP
cord-006229-7yoilsho	3293	10	Ministry	Ministry	NNP
cord-006229-7yoilsho	3293	11	of	of	IN
cord-006229-7yoilsho	3293	12	Education	Education	NNP
cord-006229-7yoilsho	3293	13	and	and	CC
cord-006229-7yoilsho	3293	14	Research	Research	NNP
cord-006229-7yoilsho	3293	15	(	(	-LRB-
cord-006229-7yoilsho	3293	16	BMBF	BMBF	NNP
cord-006229-7yoilsho	3293	17	)	)	-RRB-
cord-006229-7yoilsho	3293	18	-03X0149A.	-03X0149A.	.
cord-006229-7yoilsho	3294	1	Core	core	NN
cord-006229-7yoilsho	3294	2	or	or	CC
cord-006229-7yoilsho	3294	3	coating	coating	NN
cord-006229-7yoilsho	3294	4	material	material	NN
cord-006229-7yoilsho	3294	5	?	?	.
cord-006229-7yoilsho	3295	1	What	what	WP
cord-006229-7yoilsho	3295	2	dictates	dictate	VBZ
cord-006229-7yoilsho	3295	3	the	the	DT
cord-006229-7yoilsho	3295	4	uptake	uptake	NN
cord-006229-7yoilsho	3295	5	and	and	CC
cord-006229-7yoilsho	3295	6	translocation	translocation	NN
cord-006229-7yoilsho	3295	7	of	of	IN
cord-006229-7yoilsho	3295	8	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	3295	9	in	in	IN
cord-006229-7yoilsho	3295	10	vitro	vitro	FW
cord-006229-7yoilsho	3295	11	?	?	.
cord-006229-7yoilsho	3296	1	Nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	3296	2	are	be	VBP
cord-006229-7yoilsho	3296	3	becoming	become	VBG
cord-006229-7yoilsho	3296	4	increasingly	increasingly	RB
cord-006229-7yoilsho	3296	5	important	important	JJ
cord-006229-7yoilsho	3296	6	role	role	NN
cord-006229-7yoilsho	3296	7	in	in	IN
cord-006229-7yoilsho	3296	8	consumer	consumer	NN
cord-006229-7yoilsho	3296	9	-	-	HYPH
cord-006229-7yoilsho	3296	10	related	relate	VBN
cord-006229-7yoilsho	3296	11	products	product	NNS
cord-006229-7yoilsho	3296	12	.	.	.
cord-006229-7yoilsho	3297	1	Understanding	understand	VBG
cord-006229-7yoilsho	3297	2	the	the	DT
cord-006229-7yoilsho	3297	3	interactions	interaction	NNS
cord-006229-7yoilsho	3297	4	between	between	IN
cord-006229-7yoilsho	3297	5	nanoscaled	nanoscaled	JJ
cord-006229-7yoilsho	3297	6	objects	object	NNS
cord-006229-7yoilsho	3297	7	and	and	CC
cord-006229-7yoilsho	3297	8	living	living	NN
cord-006229-7yoilsho	3297	9	cells	cell	NNS
cord-006229-7yoilsho	3297	10	is	be	VBZ
cord-006229-7yoilsho	3297	11	therefore	therefore	RB
cord-006229-7yoilsho	3297	12	of	of	IN
cord-006229-7yoilsho	3297	13	great	great	JJ
cord-006229-7yoilsho	3297	14	importance	importance	NN
cord-006229-7yoilsho	3297	15	for	for	IN
cord-006229-7yoilsho	3297	16	risk	risk	NN
cord-006229-7yoilsho	3297	17	assessment	assessment	NN
cord-006229-7yoilsho	3297	18	.	.	.
cord-006229-7yoilsho	3298	1	In	in	IN
cord-006229-7yoilsho	3298	2	this	this	DT
cord-006229-7yoilsho	3298	3	context	context	NN
cord-006229-7yoilsho	3298	4	,	,	,
cord-006229-7yoilsho	3298	5	it	-PRON-	PRP
cord-006229-7yoilsho	3298	6	is	be	VBZ
cord-006229-7yoilsho	3298	7	generally	generally	RB
cord-006229-7yoilsho	3298	8	accepted	accept	VBN
cord-006229-7yoilsho	3298	9	that	that	IN
cord-006229-7yoilsho	3298	10	nanoparticle	nanoparticle	NN
cord-006229-7yoilsho	3298	11	size	size	NN
cord-006229-7yoilsho	3298	12	and	and	CC
cord-006229-7yoilsho	3298	13	shape	shape	NN
cord-006229-7yoilsho	3298	14	are	be	VBP
cord-006229-7yoilsho	3298	15	crucial	crucial	JJ
cord-006229-7yoilsho	3298	16	parameters	parameter	NNS
cord-006229-7yoilsho	3298	17	regarding	regard	VBG
cord-006229-7yoilsho	3298	18	the	the	DT
cord-006229-7yoilsho	3298	19	potential	potential	NN
cord-006229-7yoilsho	3298	20	of	of	IN
cord-006229-7yoilsho	3298	21	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	3298	22	to	to	TO
cord-006229-7yoilsho	3298	23	penetrate	penetrate	VB
cord-006229-7yoilsho	3298	24	cell	cell	NN
cord-006229-7yoilsho	3298	25	membranes	membrane	NNS
cord-006229-7yoilsho	3298	26	and	and	CC
cord-006229-7yoilsho	3298	27	epithelial	epithelial	JJ
cord-006229-7yoilsho	3298	28	barriers	barrier	NNS
cord-006229-7yoilsho	3298	29	.	.	.
cord-006229-7yoilsho	3299	1	Current	current	JJ
cord-006229-7yoilsho	3299	2	research	research	NN
cord-006229-7yoilsho	3299	3	in	in	IN
cord-006229-7yoilsho	3299	4	this	this	DT
cord-006229-7yoilsho	3299	5	field	field	NN
cord-006229-7yoilsho	3299	6	additionally	additionally	RB
cord-006229-7yoilsho	3299	7	focuses	focus	VBZ
cord-006229-7yoilsho	3299	8	on	on	IN
cord-006229-7yoilsho	3299	9	the	the	DT
cord-006229-7yoilsho	3299	10	particle	particle	NN
cord-006229-7yoilsho	3299	11	coating	coating	NN
cord-006229-7yoilsho	3299	12	material	material	NN
cord-006229-7yoilsho	3299	13	.	.	.
cord-006229-7yoilsho	3300	1	In	in	IN
cord-006229-7yoilsho	3300	2	order	order	NN
cord-006229-7yoilsho	3300	3	to	to	TO
cord-006229-7yoilsho	3300	4	distinguish	distinguish	VB
cord-006229-7yoilsho	3300	5	between	between	IN
cord-006229-7yoilsho	3300	6	core	core	NN
cord-006229-7yoilsho	3300	7	-	-	:
cord-006229-7yoilsho	3300	8	and	and	CC
cord-006229-7yoilsho	3300	9	coating	coating	NN
cord-006229-7yoilsho	3300	10	-	-	HYPH
cord-006229-7yoilsho	3300	11	related	relate	VBN
cord-006229-7yoilsho	3300	12	effects	effect	NNS
cord-006229-7yoilsho	3300	13	in	in	IN
cord-006229-7yoilsho	3300	14	nanoparticle	nanoparticle	NN
cord-006229-7yoilsho	3300	15	uptake	uptake	NN
cord-006229-7yoilsho	3300	16	and	and	CC
cord-006229-7yoilsho	3300	17	translocation	translocation	NN
cord-006229-7yoilsho	3300	18	behavior	behavior	NN
cord-006229-7yoilsho	3300	19	,	,	,
cord-006229-7yoilsho	3300	20	this	this	DT
cord-006229-7yoilsho	3300	21	study	study	NN
cord-006229-7yoilsho	3300	22	investigated	investigate	VBD
cord-006229-7yoilsho	3300	23	two	two	CD
cord-006229-7yoilsho	3300	24	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	3300	25	equal	equal	JJ
cord-006229-7yoilsho	3300	26	in	in	IN
cord-006229-7yoilsho	3300	27	size	size	NN
cord-006229-7yoilsho	3300	28	,	,	,
cord-006229-7yoilsho	3300	29	coating	coating	NN
cord-006229-7yoilsho	3300	30	and	and	CC
cord-006229-7yoilsho	3300	31	charge	charge	NN
cord-006229-7yoilsho	3300	32	but	but	CC
cord-006229-7yoilsho	3300	33	different	different	JJ
cord-006229-7yoilsho	3300	34	in	in	IN
cord-006229-7yoilsho	3300	35	core	core	NN
cord-006229-7yoilsho	3300	36	material	material	NN
cord-006229-7yoilsho	3300	37	.	.	.
cord-006229-7yoilsho	3301	1	Silver	silver	NN
cord-006229-7yoilsho	3301	2	and	and	CC
cord-006229-7yoilsho	3301	3	iron	iron	NN
cord-006229-7yoilsho	3301	4	oxide	oxide	NN
cord-006229-7yoilsho	3301	5	were	be	VBD
cord-006229-7yoilsho	3301	6	chosen	choose	VBN
cord-006229-7yoilsho	3301	7	as	as	IN
cord-006229-7yoilsho	3301	8	core	core	NN
cord-006229-7yoilsho	3301	9	materials	material	NNS
cord-006229-7yoilsho	3301	10	to	to	TO
cord-006229-7yoilsho	3301	11	ensure	ensure	VB
cord-006229-7yoilsho	3301	12	similar	similar	JJ
cord-006229-7yoilsho	3301	13	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	3301	14	characteristics	characteristic	NNS
cord-006229-7yoilsho	3301	15	after	after	IN
cord-006229-7yoilsho	3301	16	particle	particle	NN
cord-006229-7yoilsho	3301	17	synthesis	synthesis	NN
cord-006229-7yoilsho	3301	18	.	.	.
cord-006229-7yoilsho	3302	1	Nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	3302	2	were	be	VBD
cord-006229-7yoilsho	3302	3	coated	coat	VBN
cord-006229-7yoilsho	3302	4	with	with	IN
cord-006229-7yoilsho	3302	5	poly	poly	NNP
cord-006229-7yoilsho	3302	6	(	(	-LRB-
cord-006229-7yoilsho	3302	7	acrylic	acrylic	JJ
cord-006229-7yoilsho	3302	8	acid	acid	NN
cord-006229-7yoilsho	3302	9	)	)	-RRB-
cord-006229-7yoilsho	3302	10	(	(	-LRB-
cord-006229-7yoilsho	3302	11	PAS	pas	NN
cord-006229-7yoilsho	3302	12	)	)	-RRB-
cord-006229-7yoilsho	3302	13	and	and	CC
cord-006229-7yoilsho	3302	14	extensively	extensively	RB
cord-006229-7yoilsho	3302	15	characterized	characterize	VBN
cord-006229-7yoilsho	3302	16	by	by	IN
cord-006229-7yoilsho	3302	17	TEM	tem	NN
cord-006229-7yoilsho	3302	18	(	(	-LRB-
cord-006229-7yoilsho	3302	19	transmission	transmission	NN
cord-006229-7yoilsho	3302	20	electron	electron	NN
cord-006229-7yoilsho	3302	21	microscopy	microscopy	NN
cord-006229-7yoilsho	3302	22	)	)	-RRB-
cord-006229-7yoilsho	3302	23	,	,	,
cord-006229-7yoilsho	3302	24	SAXS	SAXS	NNP
cord-006229-7yoilsho	3302	25	(	(	-LRB-
cord-006229-7yoilsho	3302	26	Small	Small	NNP
cord-006229-7yoilsho	3302	27	-	-	HYPH
cord-006229-7yoilsho	3302	28	Angle	angle	NN
cord-006229-7yoilsho	3302	29	X	x	NN
cord-006229-7yoilsho	3302	30	-	-	NN
cord-006229-7yoilsho	3302	31	ray	ray	NN
cord-006229-7yoilsho	3302	32	Scattering	scattering	NN
cord-006229-7yoilsho	3302	33	)	)	-RRB-
cord-006229-7yoilsho	3302	34	,	,	,
cord-006229-7yoilsho	3302	35	Zetasizer	Zetasizer	NNP
cord-006229-7yoilsho	3302	36	TM	TM	NNP
cord-006229-7yoilsho	3302	37	and	and	CC
cord-006229-7yoilsho	3302	38	NanoSight	NanoSight	NNP
cord-006229-7yoilsho	3302	39	TM	TM	NNP
cord-006229-7yoilsho	3302	40	.	.	.
cord-006229-7yoilsho	3303	1	For	for	IN
cord-006229-7yoilsho	3303	2	uptake	uptake	NN
cord-006229-7yoilsho	3303	3	and	and	CC
cord-006229-7yoilsho	3303	4	transport	transport	NN
cord-006229-7yoilsho	3303	5	studies	study	NNS
cord-006229-7yoilsho	3303	6	the	the	DT
cord-006229-7yoilsho	3303	7	widely	widely	RB
cord-006229-7yoilsho	3303	8	used	use	VBN
cord-006229-7yoilsho	3303	9	human	human	JJ
cord-006229-7yoilsho	3303	10	intestinal	intestinal	JJ
cord-006229-7yoilsho	3303	11	Caco-2	Caco-2	NNP
cord-006229-7yoilsho	3303	12	model	model	NN
cord-006229-7yoilsho	3303	13	in	in	IN
cord-006229-7yoilsho	3303	14	a	a	DT
cord-006229-7yoilsho	3304	1	Transwell	Transwell	NNP
cord-006229-7yoilsho	3304	2	TM	TM	NNP
cord-006229-7yoilsho	3304	3	-system	-system	NN
cord-006229-7yoilsho	3305	1	with	with	IN
cord-006229-7yoilsho	3305	2	subsequent	subsequent	JJ
cord-006229-7yoilsho	3305	3	elemental	elemental	JJ
cord-006229-7yoilsho	3305	4	analysis	analysis	NN
cord-006229-7yoilsho	3305	5	(	(	-LRB-
cord-006229-7yoilsho	3305	6	AAS	AAS	NNP
cord-006229-7yoilsho	3305	7	)	)	-RRB-
cord-006229-7yoilsho	3305	8	was	be	VBD
cord-006229-7yoilsho	3305	9	used	use	VBN
cord-006229-7yoilsho	3305	10	.	.	.
cord-006229-7yoilsho	3306	1	For	for	IN
cord-006229-7yoilsho	3306	2	evaluation	evaluation	NN
cord-006229-7yoilsho	3306	3	and	and	CC
cord-006229-7yoilsho	3306	4	particle	particle	NN
cord-006229-7yoilsho	3306	5	visualization	visualization	NN
cord-006229-7yoilsho	3306	6	transmission	transmission	NN
cord-006229-7yoilsho	3306	7	electron	electron	NN
cord-006229-7yoilsho	3306	8	microscopy	microscopy	NN
cord-006229-7yoilsho	3306	9	(	(	-LRB-
cord-006229-7yoilsho	3306	10	TEM	TEM	NNP
cord-006229-7yoilsho	3306	11	)	)	-RRB-
cord-006229-7yoilsho	3306	12	and	and	CC
cord-006229-7yoilsho	3306	13	Ion	Ion	NNP
cord-006229-7yoilsho	3306	14	Beam	Beam	NNP
cord-006229-7yoilsho	3306	15	Microscopy	Microscopy	NNP
cord-006229-7yoilsho	3306	16	(	(	-LRB-
cord-006229-7yoilsho	3306	17	IBM	IBM	NNP
cord-006229-7yoilsho	3306	18	)	)	-RRB-
cord-006229-7yoilsho	3306	19	were	be	VBD
cord-006229-7yoilsho	3306	20	conducted	conduct	VBN
cord-006229-7yoilsho	3306	21	.	.	.
cord-006229-7yoilsho	3307	1	Although	although	IN
cord-006229-7yoilsho	3307	2	similar	similar	JJ
cord-006229-7yoilsho	3307	3	in	in	IN
cord-006229-7yoilsho	3307	4	size	size	NN
cord-006229-7yoilsho	3307	5	,	,	,
cord-006229-7yoilsho	3307	6	charge	charge	NN
cord-006229-7yoilsho	3307	7	and	and	CC
cord-006229-7yoilsho	3307	8	coating	coating	NN
cord-006229-7yoilsho	3307	9	material	material	NN
cord-006229-7yoilsho	3307	10	,	,	,
cord-006229-7yoilsho	3307	11	the	the	DT
cord-006229-7yoilsho	3307	12	behavior	behavior	NN
cord-006229-7yoilsho	3307	13	of	of	IN
cord-006229-7yoilsho	3307	14	particles	particle	NNS
cord-006229-7yoilsho	3307	15	in	in	IN
cord-006229-7yoilsho	3307	16	Caco-2	caco-2	NN
cord-006229-7yoilsho	3307	17	cells	cell	NNS
cord-006229-7yoilsho	3307	18	was	be	VBD
cord-006229-7yoilsho	3307	19	quite	quite	RB
cord-006229-7yoilsho	3307	20	different	different	JJ
cord-006229-7yoilsho	3307	21	.	.	.
cord-006229-7yoilsho	3308	1	The	the	DT
cord-006229-7yoilsho	3308	2	internalized	internalize	VBN
cord-006229-7yoilsho	3308	3	amount	amount	NN
cord-006229-7yoilsho	3308	4	was	be	VBD
cord-006229-7yoilsho	3308	5	comparable	comparable	JJ
cord-006229-7yoilsho	3308	6	,	,	,
cord-006229-7yoilsho	3308	7	but	but	CC
cord-006229-7yoilsho	3308	8	PAS	pas	NN
cord-006229-7yoilsho	3308	9	-	-	HYPH
cord-006229-7yoilsho	3308	10	coated	coat	VBN
cord-006229-7yoilsho	3308	11	iron	iron	NN
cord-006229-7yoilsho	3308	12	oxide	oxide	NN
cord-006229-7yoilsho	3308	13	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	3308	14	were	be	VBD
cord-006229-7yoilsho	3308	15	additionally	additionally	RB
cord-006229-7yoilsho	3308	16	transported	transport	VBN
cord-006229-7yoilsho	3308	17	through	through	IN
cord-006229-7yoilsho	3308	18	the	the	DT
cord-006229-7yoilsho	3308	19	cells	cell	NNS
cord-006229-7yoilsho	3308	20	.	.	.
cord-006229-7yoilsho	3309	1	By	by	IN
cord-006229-7yoilsho	3309	2	contrast	contrast	NN
cord-006229-7yoilsho	3309	3	,	,	,
cord-006229-7yoilsho	3309	4	PAScoated	pascoated	JJ
cord-006229-7yoilsho	3309	5	silver	silver	NN
cord-006229-7yoilsho	3309	6	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	3309	7	remained	remain	VBD
cord-006229-7yoilsho	3309	8	in	in	IN
cord-006229-7yoilsho	3309	9	the	the	DT
cord-006229-7yoilsho	3309	10	cells	cell	NNS
cord-006229-7yoilsho	3309	11	.	.	.
cord-006229-7yoilsho	3310	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	3310	2	findings	finding	NNS
cord-006229-7yoilsho	3310	3	suggest	suggest	VBP
cord-006229-7yoilsho	3310	4	that	that	IN
cord-006229-7yoilsho	3310	5	the	the	DT
cord-006229-7yoilsho	3310	6	coating	coating	NN
cord-006229-7yoilsho	3310	7	material	material	NN
cord-006229-7yoilsho	3310	8	influenced	influence	VBN
cord-006229-7yoilsho	3310	9	only	only	RB
cord-006229-7yoilsho	3310	10	the	the	DT
cord-006229-7yoilsho	3310	11	uptake	uptake	NN
cord-006229-7yoilsho	3310	12	of	of	IN
cord-006229-7yoilsho	3310	13	the	the	DT
cord-006229-7yoilsho	3310	14	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	3310	15	whereas	whereas	IN
cord-006229-7yoilsho	3310	16	the	the	DT
cord-006229-7yoilsho	3310	17	translocation	translocation	NN
cord-006229-7yoilsho	3310	18	was	be	VBD
cord-006229-7yoilsho	3310	19	determined	determine	VBN
cord-006229-7yoilsho	3310	20	by	by	IN
cord-006229-7yoilsho	3310	21	the	the	DT
cord-006229-7yoilsho	3310	22	core	core	NN
cord-006229-7yoilsho	3310	23	material	material	NN
cord-006229-7yoilsho	3310	24	.	.	.
cord-006229-7yoilsho	3311	1	In	in	IN
cord-006229-7yoilsho	3311	2	summary	summary	NN
cord-006229-7yoilsho	3311	3	,	,	,
cord-006229-7yoilsho	3311	4	a	a	DT
cord-006229-7yoilsho	3311	5	core	core	NN
cord-006229-7yoilsho	3311	6	-	-	HYPH
cord-006229-7yoilsho	3311	7	dependent	dependent	JJ
cord-006229-7yoilsho	3311	8	effect	effect	NN
cord-006229-7yoilsho	3311	9	on	on	IN
cord-006229-7yoilsho	3311	10	nanoparticle	nanoparticle	NN
cord-006229-7yoilsho	3311	11	translocation	translocation	NN
cord-006229-7yoilsho	3311	12	was	be	VBD
cord-006229-7yoilsho	3311	13	revealed	reveal	VBN
cord-006229-7yoilsho	3311	14	.	.	.
cord-006229-7yoilsho	3312	1	Both	both	DT
cord-006229-7yoilsho	3312	2	the	the	DT
cord-006229-7yoilsho	3312	3	uptake	uptake	NN
cord-006229-7yoilsho	3312	4	and	and	CC
cord-006229-7yoilsho	3312	5	transport	transport	NN
cord-006229-7yoilsho	3312	6	of	of	IN
cord-006229-7yoilsho	3312	7	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	3312	8	in	in	IN
cord-006229-7yoilsho	3312	9	and	and	CC
cord-006229-7yoilsho	3312	10	through	through	IN
cord-006229-7yoilsho	3312	11	cells	cell	NNS
cord-006229-7yoilsho	3312	12	should	should	MD
cord-006229-7yoilsho	3312	13	be	be	VB
cord-006229-7yoilsho	3312	14	considered	consider	VBN
cord-006229-7yoilsho	3312	15	when	when	WRB
cord-006229-7yoilsho	3312	16	discussing	discuss	VBG
cord-006229-7yoilsho	3312	17	nanoparticle	nanoparticle	NN
cord-006229-7yoilsho	3312	18	fate	fate	NN
cord-006229-7yoilsho	3312	19	and	and	CC
cord-006229-7yoilsho	3312	20	safety	safety	NN
cord-006229-7yoilsho	3312	21	.	.	.
cord-006229-7yoilsho	3313	1	Nanotechnology	nanotechnology	NN
cord-006229-7yoilsho	3313	2	is	be	VBZ
cord-006229-7yoilsho	3313	3	having	have	VBG
cord-006229-7yoilsho	3313	4	a	a	DT
cord-006229-7yoilsho	3313	5	great	great	JJ
cord-006229-7yoilsho	3313	6	impact	impact	NN
cord-006229-7yoilsho	3313	7	not	not	RB
cord-006229-7yoilsho	3313	8	only	only	RB
cord-006229-7yoilsho	3313	9	on	on	IN
cord-006229-7yoilsho	3313	10	basic	basic	JJ
cord-006229-7yoilsho	3313	11	research	research	NN
cord-006229-7yoilsho	3313	12	but	but	CC
cord-006229-7yoilsho	3313	13	also	also	RB
cord-006229-7yoilsho	3313	14	on	on	IN
cord-006229-7yoilsho	3313	15	many	many	JJ
cord-006229-7yoilsho	3313	16	sectors	sector	NNS
cord-006229-7yoilsho	3313	17	of	of	IN
cord-006229-7yoilsho	3313	18	industry	industry	NN
cord-006229-7yoilsho	3313	19	opening	open	VBG
cord-006229-7yoilsho	3313	20	the	the	DT
cord-006229-7yoilsho	3313	21	market	market	NN
cord-006229-7yoilsho	3313	22	for	for	IN
cord-006229-7yoilsho	3313	23	numerous	numerous	JJ
cord-006229-7yoilsho	3313	24	new	new	JJ
cord-006229-7yoilsho	3313	25	applications	application	NNS
cord-006229-7yoilsho	3313	26	ranging	range	VBG
cord-006229-7yoilsho	3313	27	from	from	IN
cord-006229-7yoilsho	3313	28	electronics	electronic	NNS
cord-006229-7yoilsho	3313	29	to	to	IN
cord-006229-7yoilsho	3313	30	the	the	DT
cord-006229-7yoilsho	3313	31	health	health	NN
cord-006229-7yoilsho	3313	32	care	care	NN
cord-006229-7yoilsho	3313	33	system	system	NN
cord-006229-7yoilsho	3313	34	.	.	.
cord-006229-7yoilsho	3314	1	Besides	besides	IN
cord-006229-7yoilsho	3314	2	their	-PRON-	PRP$
cord-006229-7yoilsho	3314	3	great	great	JJ
cord-006229-7yoilsho	3314	4	innovative	innovative	JJ
cord-006229-7yoilsho	3314	5	potential	potential	NN
cord-006229-7yoilsho	3314	6	,	,	,
cord-006229-7yoilsho	3314	7	the	the	DT
cord-006229-7yoilsho	3314	8	large	large	JJ
cord-006229-7yoilsho	3314	9	variety	variety	NN
cord-006229-7yoilsho	3314	10	of	of	IN
cord-006229-7yoilsho	3314	11	existing	exist	VBG
cord-006229-7yoilsho	3314	12	synthetic	synthetic	JJ
cord-006229-7yoilsho	3314	13	nanomaterials	nanomaterial	NNS
cord-006229-7yoilsho	3314	14	used	use	VBN
cord-006229-7yoilsho	3314	15	in	in	IN
cord-006229-7yoilsho	3314	16	the	the	DT
cord-006229-7yoilsho	3314	17	last	last	JJ
cord-006229-7yoilsho	3314	18	decade	decade	NN
cord-006229-7yoilsho	3314	19	represents	represent	VBZ
cord-006229-7yoilsho	3314	20	a	a	DT
cord-006229-7yoilsho	3314	21	major	major	JJ
cord-006229-7yoilsho	3314	22	challenge	challenge	NN
cord-006229-7yoilsho	3314	23	for	for	IN
cord-006229-7yoilsho	3314	24	scientists	scientist	NNS
cord-006229-7yoilsho	3314	25	and	and	CC
cord-006229-7yoilsho	3314	26	regulators	regulator	NNS
cord-006229-7yoilsho	3314	27	in	in	IN
cord-006229-7yoilsho	3314	28	terms	term	NNS
cord-006229-7yoilsho	3314	29	of	of	IN
cord-006229-7yoilsho	3314	30	measuring	measure	VBG
cord-006229-7yoilsho	3314	31	and	and	CC
cord-006229-7yoilsho	3314	32	assessing	assess	VBG
cord-006229-7yoilsho	3314	33	the	the	DT
cord-006229-7yoilsho	3314	34	potential	potential	JJ
cord-006229-7yoilsho	3314	35	hazard	hazard	NN
cord-006229-7yoilsho	3314	36	caused	cause	VBN
cord-006229-7yoilsho	3314	37	by	by	IN
cord-006229-7yoilsho	3314	38	the	the	DT
cord-006229-7yoilsho	3314	39	materials	material	NNS
cord-006229-7yoilsho	3314	40	or	or	CC
cord-006229-7yoilsho	3314	41	the	the	DT
cord-006229-7yoilsho	3314	42	products	product	NNS
cord-006229-7yoilsho	3314	43	themselves	-PRON-	PRP
cord-006229-7yoilsho	3314	44	.	.	.
cord-006229-7yoilsho	3315	1	Equally	equally	RB
cord-006229-7yoilsho	3315	2	,	,	,
cord-006229-7yoilsho	3315	3	consumers	consumer	NNS
cord-006229-7yoilsho	3315	4	often	often	RB
cord-006229-7yoilsho	3315	5	miss	miss	VBP
cord-006229-7yoilsho	3315	6	reliable	reliable	JJ
cord-006229-7yoilsho	3315	7	and	and	CC
cord-006229-7yoilsho	3315	8	easy	easy	JJ
cord-006229-7yoilsho	3315	9	-	-	HYPH
cord-006229-7yoilsho	3315	10	to	to	TO
cord-006229-7yoilsho	3315	11	-	-	HYPH
cord-006229-7yoilsho	3315	12	understand	understand	VB
cord-006229-7yoilsho	3315	13	information	information	NN
cord-006229-7yoilsho	3315	14	on	on	IN
cord-006229-7yoilsho	3315	15	nanomaterials	nanomaterial	NNS
cord-006229-7yoilsho	3315	16	and	and	CC
cord-006229-7yoilsho	3315	17	nanotechnology	nanotechnology	NN
cord-006229-7yoilsho	3315	18	and	and	CC
cord-006229-7yoilsho	3315	19	do	do	VBP
cord-006229-7yoilsho	3315	20	not	not	RB
cord-006229-7yoilsho	3315	21	know	know	VB
cord-006229-7yoilsho	3315	22	where	where	WRB
cord-006229-7yoilsho	3315	23	to	to	TO
cord-006229-7yoilsho	3315	24	get	get	VB
cord-006229-7yoilsho	3315	25	such	such	JJ
cord-006229-7yoilsho	3315	26	information	information	NN
cord-006229-7yoilsho	3315	27	.	.	.
cord-006229-7yoilsho	3316	1	Therefore	therefore	RB
cord-006229-7yoilsho	3316	2	,	,	,
cord-006229-7yoilsho	3316	3	the	the	DT
cord-006229-7yoilsho	3316	4	international	international	JJ
cord-006229-7yoilsho	3316	5	DaNa	DaNa	NNP
cord-006229-7yoilsho	3316	6	2.0	2.0	CD
cord-006229-7yoilsho	3316	7	expert	expert	NN
cord-006229-7yoilsho	3316	8	team	team	NN
cord-006229-7yoilsho	3316	9	brings	bring	VBZ
cord-006229-7yoilsho	3316	10	together	together	RB
cord-006229-7yoilsho	3316	11	its	-PRON-	PRP$
cord-006229-7yoilsho	3316	12	expertise	expertise	NN
cord-006229-7yoilsho	3316	13	and	and	CC
cord-006229-7yoilsho	3316	14	knowledge	knowledge	NN
cord-006229-7yoilsho	3316	15	from	from	IN
cord-006229-7yoilsho	3316	16	different	different	JJ
cord-006229-7yoilsho	3316	17	research	research	NN
cord-006229-7yoilsho	3316	18	areas	area	NNS
cord-006229-7yoilsho	3316	19	dealing	deal	VBG
cord-006229-7yoilsho	3316	20	with	with	IN
cord-006229-7yoilsho	3316	21	all	all	DT
cord-006229-7yoilsho	3316	22	aspects	aspect	NNS
cord-006229-7yoilsho	3316	23	of	of	IN
cord-006229-7yoilsho	3316	24	nanosafety	nanosafety	NNP
cord-006229-7yoilsho	3316	25	research	research	NN
cord-006229-7yoilsho	3316	26	in	in	IN
cord-006229-7yoilsho	3316	27	order	order	NN
cord-006229-7yoilsho	3316	28	to	to	TO
cord-006229-7yoilsho	3316	29	create	create	VB
cord-006229-7yoilsho	3316	30	and	and	CC
cord-006229-7yoilsho	3316	31	provide	provide	VB
cord-006229-7yoilsho	3316	32	easy	easy	JJ
cord-006229-7yoilsho	3316	33	-	-	HYPH
cord-006229-7yoilsho	3316	34	to	to	TO
cord-006229-7yoilsho	3316	35	-	-	HYPH
cord-006229-7yoilsho	3316	36	understand	understand	VB
cord-006229-7yoilsho	3316	37	,	,	,
cord-006229-7yoilsho	3316	38	up	up	IN
cord-006229-7yoilsho	3316	39	-	-	HYPH
cord-006229-7yoilsho	3316	40	to	to	IN
cord-006229-7yoilsho	3316	41	-	-	HYPH
cord-006229-7yoilsho	3316	42	date	date	NN
cord-006229-7yoilsho	3316	43	and	and	CC
cord-006229-7yoilsho	3316	44	quality	quality	NN
cord-006229-7yoilsho	3316	45	-	-	HYPH
cord-006229-7yoilsho	3316	46	approved	approve	VBN
cord-006229-7yoilsho	3316	47	nanomaterials	nanomaterial	NNS
cord-006229-7yoilsho	3316	48	'	'	POS
cord-006229-7yoilsho	3316	49	knowledge	knowledge	NN
cord-006229-7yoilsho	3316	50	base	base	NN
cord-006229-7yoilsho	3316	51	on	on	IN
cord-006229-7yoilsho	3316	52	www.nanopartikel.info	www.nanopartikel.info	CD
cord-006229-7yoilsho	3316	53	.	.	.
cord-006229-7yoilsho	3317	1	This	this	DT
cord-006229-7yoilsho	3317	2	information	information	NN
cord-006229-7yoilsho	3317	3	platform	platform	NN
cord-006229-7yoilsho	3317	4	covers	cover	VBZ
cord-006229-7yoilsho	3317	5	the	the	DT
cord-006229-7yoilsho	3317	6	25	25	CD
cord-006229-7yoilsho	3317	7	market	market	NN
cord-006229-7yoilsho	3317	8	-	-	HYPH
cord-006229-7yoilsho	3317	9	relevant	relevant	JJ
cord-006229-7yoilsho	3317	10	nanomaterials	nanomaterial	NNS
cord-006229-7yoilsho	3317	11	focusing	focus	VBG
cord-006229-7yoilsho	3317	12	on	on	IN
cord-006229-7yoilsho	3317	13	their	-PRON-	PRP$
cord-006229-7yoilsho	3317	14	effects	effect	NNS
cord-006229-7yoilsho	3317	15	on	on	IN
cord-006229-7yoilsho	3317	16	the	the	DT
cord-006229-7yoilsho	3317	17	safety	safety	NN
cord-006229-7yoilsho	3317	18	of	of	IN
cord-006229-7yoilsho	3317	19	humans	human	NNS
cord-006229-7yoilsho	3317	20	and	and	CC
cord-006229-7yoilsho	3317	21	the	the	DT
cord-006229-7yoilsho	3317	22	environment	environment	NN
cord-006229-7yoilsho	3317	23	.	.	.
cord-006229-7yoilsho	3318	1	In	in	IN
cord-006229-7yoilsho	3318	2	order	order	NN
cord-006229-7yoilsho	3318	3	to	to	TO
cord-006229-7yoilsho	3318	4	manage	manage	VB
cord-006229-7yoilsho	3318	5	and	and	CC
cord-006229-7yoilsho	3318	6	asses	ass	NNS
cord-006229-7yoilsho	3318	7	the	the	DT
cord-006229-7yoilsho	3318	8	rapidly	rapidly	RB
cord-006229-7yoilsho	3318	9	increasing	increase	VBG
cord-006229-7yoilsho	3318	10	number	number	NN
cord-006229-7yoilsho	3318	11	of	of	IN
cord-006229-7yoilsho	3318	12	publications	publication	NNS
cord-006229-7yoilsho	3318	13	related	relate	VBN
cord-006229-7yoilsho	3318	14	to	to	IN
cord-006229-7yoilsho	3318	15	nanosafety	nanosafety	NNP
cord-006229-7yoilsho	3318	16	issues	issue	NNS
cord-006229-7yoilsho	3318	17	,	,	,
cord-006229-7yoilsho	3318	18	the	the	DT
cord-006229-7yoilsho	3318	19	DaNa	DaNa	NNP
cord-006229-7yoilsho	3318	20	2.0	2.0	CD
cord-006229-7yoilsho	3318	21	project	project	NN
cord-006229-7yoilsho	3318	22	developed	develop	VBD
cord-006229-7yoilsho	3318	23	a	a	DT
cord-006229-7yoilsho	3318	24	customised	customised	JJ
cord-006229-7yoilsho	3318	25	methodology	methodology	NN
cord-006229-7yoilsho	3318	26	«	«	''
cord-006229-7yoilsho	3318	27	Literature	Literature	NNP
cord-006229-7yoilsho	3318	28	Criteria	Criteria	NNP
cord-006229-7yoilsho	3318	29	Checklist	Checklist	NNP
cord-006229-7yoilsho	3318	30	»	»	''
cord-006229-7yoilsho	3318	31	,	,	,
cord-006229-7yoilsho	3318	32	which	which	WDT
cord-006229-7yoilsho	3318	33	includes	include	VBZ
cord-006229-7yoilsho	3318	34	mandatory	mandatory	JJ
cord-006229-7yoilsho	3318	35	and	and	CC
cord-006229-7yoilsho	3318	36	desirable	desirable	JJ
cord-006229-7yoilsho	3318	37	assessment	assessment	NN
cord-006229-7yoilsho	3318	38	criteria	criterion	NNS
cord-006229-7yoilsho	3318	39	covering	cover	VBG
cord-006229-7yoilsho	3318	40	physico	physico	NN
cord-006229-7yoilsho	3318	41	-	-	HYPH
cord-006229-7yoilsho	3318	42	chemical	chemical	NN
cord-006229-7yoilsho	3318	43	characterisation	characterisation	NN
cord-006229-7yoilsho	3318	44	,	,	,
cord-006229-7yoilsho	3318	45	sample	sample	NN
cord-006229-7yoilsho	3318	46	preparation	preparation	NN
cord-006229-7yoilsho	3318	47	and	and	CC
cord-006229-7yoilsho	3318	48	(	(	-LRB-
cord-006229-7yoilsho	3318	49	biological	biological	JJ
cord-006229-7yoilsho	3318	50	)	)	-RRB-
cord-006229-7yoilsho	3318	51	testing	testing	NN
cord-006229-7yoilsho	3318	52	parameters	parameter	NNS
cord-006229-7yoilsho	3318	53	.	.	.
cord-006229-7yoilsho	3319	1	This	this	DT
cord-006229-7yoilsho	3319	2	checklist	checklist	NN
cord-006229-7yoilsho	3319	3	facilitates	facilitate	VBZ
cord-006229-7yoilsho	3319	4	the	the	DT
cord-006229-7yoilsho	3319	5	discrimination	discrimination	NN
cord-006229-7yoilsho	3319	6	between	between	IN
cord-006229-7yoilsho	3319	7	high	high	JJ
cord-006229-7yoilsho	3319	8	-	-	HYPH
cord-006229-7yoilsho	3319	9	and	and	CC
cord-006229-7yoilsho	3319	10	low	low	JJ
cord-006229-7yoilsho	3319	11	quality	quality	NN
cord-006229-7yoilsho	3319	12	publications	publication	NNS
cord-006229-7yoilsho	3319	13	and	and	CC
cord-006229-7yoilsho	3319	14	all	all	DT
cord-006229-7yoilsho	3319	15	positively	positively	RB
cord-006229-7yoilsho	3319	16	evaluated	evaluate	VBN
cord-006229-7yoilsho	3319	17	literature	literature	NN
cord-006229-7yoilsho	3319	18	is	be	VBZ
cord-006229-7yoilsho	3319	19	then	then	RB
cord-006229-7yoilsho	3319	20	fed	feed	VBN
cord-006229-7yoilsho	3319	21	into	into	IN
cord-006229-7yoilsho	3319	22	the	the	DT
cord-006229-7yoilsho	3319	23	DaNa	DaNa	NNP
cord-006229-7yoilsho	3319	24	knowledge	knowledge	NN
cord-006229-7yoilsho	3319	25	base	base	NN
cord-006229-7yoilsho	3319	26	.	.	.
cord-006229-7yoilsho	3320	1	Accounting	account	VBG
cord-006229-7yoilsho	3320	2	for	for	IN
cord-006229-7yoilsho	3320	3	the	the	DT
cord-006229-7yoilsho	3320	4	need	need	NN
cord-006229-7yoilsho	3320	5	to	to	TO
cord-006229-7yoilsho	3320	6	harmonise	harmonise	VB
cord-006229-7yoilsho	3320	7	experimental	experimental	JJ
cord-006229-7yoilsho	3320	8	practices	practice	NNS
cord-006229-7yoilsho	3320	9	,	,	,
cord-006229-7yoilsho	3320	10	the	the	DT
cord-006229-7yoilsho	3320	11	DaNa	DaNa	NNP
cord-006229-7yoilsho	3320	12	team	team	NN
cord-006229-7yoilsho	3320	13	also	also	RB
cord-006229-7yoilsho	3320	14	developed	develop	VBD
cord-006229-7yoilsho	3320	15	a	a	DT
cord-006229-7yoilsho	3320	16	template	template	NN
cord-006229-7yoilsho	3320	17	for	for	IN
cord-006229-7yoilsho	3320	18	Standard	Standard	NNP
cord-006229-7yoilsho	3320	19	Operation	Operation	NNP
cord-006229-7yoilsho	3320	20	Procedures	Procedures	NNPS
cord-006229-7yoilsho	3320	21	(	(	-LRB-
cord-006229-7yoilsho	3320	22	SOP	SOP	NNP
cord-006229-7yoilsho	3320	23	)	)	-RRB-
cord-006229-7yoilsho	3320	24	to	to	TO
cord-006229-7yoilsho	3320	25	support	support	VB
cord-006229-7yoilsho	3320	26	careful	careful	JJ
cord-006229-7yoilsho	3320	27	scientific	scientific	JJ
cord-006229-7yoilsho	3320	28	practice	practice	NN
cord-006229-7yoilsho	3320	29	.	.	.
cord-006229-7yoilsho	3321	1	Validated	validate	VBN
cord-006229-7yoilsho	3321	2	protocols	protocol	NNS
cord-006229-7yoilsho	3321	3	generated	generate	VBN
cord-006229-7yoilsho	3321	4	within	within	IN
cord-006229-7yoilsho	3321	5	the	the	DT
cord-006229-7yoilsho	3321	6	German	german	JJ
cord-006229-7yoilsho	3321	7	BMBF	BMBF	NNP
cord-006229-7yoilsho	3321	8	-	-	HYPH
cord-006229-7yoilsho	3321	9	funded	fund	VBN
cord-006229-7yoilsho	3321	10	nanosafety	nanosafety	NNP
cord-006229-7yoilsho	3321	11	research	research	NN
cord-006229-7yoilsho	3321	12	projects	project	NNS
cord-006229-7yoilsho	3321	13	are	be	VBP
cord-006229-7yoilsho	3321	14	presented	present	VBN
cord-006229-7yoilsho	3321	15	together	together	RB
cord-006229-7yoilsho	3321	16	with	with	IN
cord-006229-7yoilsho	3321	17	results	result	NNS
cord-006229-7yoilsho	3321	18	from	from	IN
cord-006229-7yoilsho	3321	19	the	the	DT
cord-006229-7yoilsho	3321	20	Swiss	Swiss	NNP
cord-006229-7yoilsho	3321	21	CCMX	CCMX	NNP
cord-006229-7yoilsho	3321	22	project	project	NN
cord-006229-7yoilsho	3321	23	V.I.G.O.	V.I.G.O.	NNP
cord-006229-7yoilsho	3321	24	and	and	CC
cord-006229-7yoilsho	3321	25	available	available	JJ
cord-006229-7yoilsho	3321	26	for	for	IN
cord-006229-7yoilsho	3321	27	download	download	NN
cord-006229-7yoilsho	3321	28	.	.	.
cord-006229-7yoilsho	3322	1	Another	another	DT
cord-006229-7yoilsho	3322	2	unique	unique	JJ
cord-006229-7yoilsho	3322	3	feature	feature	NN
cord-006229-7yoilsho	3322	4	of	of	IN
cord-006229-7yoilsho	3322	5	the	the	DT
cord-006229-7yoilsho	3322	6	DaNa	DaNa	NNP
cord-006229-7yoilsho	3322	7	knowledge	knowledge	NN
cord-006229-7yoilsho	3322	8	base	base	NN
cord-006229-7yoilsho	3322	9	is	be	VBZ
cord-006229-7yoilsho	3322	10	the	the	DT
cord-006229-7yoilsho	3322	11	integrated	integrated	JJ
cord-006229-7yoilsho	3322	12	application	application	NN
cord-006229-7yoilsho	3322	13	-	-	HYPH
cord-006229-7yoilsho	3322	14	based	base	VBN
cord-006229-7yoilsho	3322	15	database	database	NN
cord-006229-7yoilsho	3322	16	that	that	WDT
cord-006229-7yoilsho	3322	17	provides	provide	VBZ
cord-006229-7yoilsho	3322	18	a	a	DT
cord-006229-7yoilsho	3322	19	unique	unique	JJ
cord-006229-7yoilsho	3322	20	link	link	NN
cord-006229-7yoilsho	3322	21	between	between	IN
cord-006229-7yoilsho	3322	22	nanomaterials	nanomaterial	NNS
cord-006229-7yoilsho	3322	23	in	in	IN
cord-006229-7yoilsho	3322	24	real	real	JJ
cord-006229-7yoilsho	3322	25	applications	application	NNS
cord-006229-7yoilsho	3322	26	(	(	-LRB-
cord-006229-7yoilsho	3322	27	e.g.	e.g.	IN
cord-006229-7yoilsho	3322	28	environmental	environmental	JJ
cord-006229-7yoilsho	3322	29	remediation	remediation	NN
cord-006229-7yoilsho	3322	30	or	or	CC
cord-006229-7yoilsho	3322	31	medical	medical	JJ
cord-006229-7yoilsho	3322	32	products	product	NNS
cord-006229-7yoilsho	3322	33	)	)	-RRB-
cord-006229-7yoilsho	3322	34	and	and	CC
cord-006229-7yoilsho	3322	35	their	-PRON-	PRP$
cord-006229-7yoilsho	3322	36	potential	potential	JJ
cord-006229-7yoilsho	3322	37	impacts/	impacts/	ADD
cord-006229-7yoilsho	3322	38	toxicological	toxicological	JJ
cord-006229-7yoilsho	3322	39	effect(s	effect(s	XX
cord-006229-7yoilsho	3322	40	)	)	-RRB-
cord-006229-7yoilsho	3322	41	that	that	WDT
cord-006229-7yoilsho	3322	42	can	can	MD
cord-006229-7yoilsho	3322	43	be	be	VB
cord-006229-7yoilsho	3322	44	easily	easily	RB
cord-006229-7yoilsho	3322	45	accessed	access	VBN
cord-006229-7yoilsho	3322	46	by	by	IN
cord-006229-7yoilsho	3322	47	the	the	DT
cord-006229-7yoilsho	3322	48	interested	interested	JJ
cord-006229-7yoilsho	3322	49	visitor	visitor	NN
cord-006229-7yoilsho	3322	50	.	.	.
cord-006229-7yoilsho	3323	1	Additionally	additionally	RB
cord-006229-7yoilsho	3323	2	,	,	,
cord-006229-7yoilsho	3323	3	DaNa2.0	DaNa2.0	NNP
cord-006229-7yoilsho	3323	4	provides	provide	VBZ
cord-006229-7yoilsho	3323	5	a	a	DT
cord-006229-7yoilsho	3323	6	list	list	NN
cord-006229-7yoilsho	3323	7	of	of	IN
cord-006229-7yoilsho	3323	8	FAQs	faq	NNS
cord-006229-7yoilsho	3323	9	,	,	,
cord-006229-7yoilsho	3323	10	a	a	DT
cord-006229-7yoilsho	3323	11	link	link	NN
cord-006229-7yoilsho	3323	12	platform	platform	NN
cord-006229-7yoilsho	3323	13	with	with	IN
cord-006229-7yoilsho	3323	14	contact	contact	NN
cord-006229-7yoilsho	3323	15	data	datum	NNS
cord-006229-7yoilsho	3323	16	to	to	IN
cord-006229-7yoilsho	3323	17	other	other	JJ
cord-006229-7yoilsho	3323	18	information	information	NN
cord-006229-7yoilsho	3323	19	portals	portal	NNS
cord-006229-7yoilsho	3323	20	and	and	CC
cord-006229-7yoilsho	3323	21	the	the	DT
cord-006229-7yoilsho	3323	22	opportunity	opportunity	NN
cord-006229-7yoilsho	3323	23	to	to	TO
cord-006229-7yoilsho	3323	24	directly	directly	RB
cord-006229-7yoilsho	3323	25	pose	pose	VB
cord-006229-7yoilsho	3323	26	questions	question	NNS
cord-006229-7yoilsho	3323	27	to	to	IN
cord-006229-7yoilsho	3323	28	our	-PRON-	PRP$
cord-006229-7yoilsho	3323	29	experts	expert	NNS
cord-006229-7yoilsho	3323	30	via	via	IN
cord-006229-7yoilsho	3323	31	E	e	NN
cord-006229-7yoilsho	3323	32	-	-	NN
cord-006229-7yoilsho	3323	33	mail	mail	NN
cord-006229-7yoilsho	3323	34	.	.	.
cord-006229-7yoilsho	3324	1	DaNa	DaNa	NNP
cord-006229-7yoilsho	3324	2	2.0	2.0	NNP
cord-006229-7yoilsho	3324	3	is	be	VBZ
cord-006229-7yoilsho	3324	4	also	also	RB
cord-006229-7yoilsho	3324	5	present	present	JJ
cord-006229-7yoilsho	3324	6	on	on	IN
cord-006229-7yoilsho	3324	7	Twitter	Twitter	NNP
cord-006229-7yoilsho	3324	8	,	,	,
cord-006229-7yoilsho	3324	9	follow	follow	VB
cord-006229-7yoilsho	3324	10	us	-PRON-	PRP
cord-006229-7yoilsho	3324	11	@nano_info	@nano_info	NNP
cord-006229-7yoilsho	3324	12	.	.	.
cord-006229-7yoilsho	3325	1	Background	background	NN
cord-006229-7yoilsho	3325	2	:	:	:
cord-006229-7yoilsho	3326	1	Particulate	particulate	NN
cord-006229-7yoilsho	3326	2	matter	matter	NN
cord-006229-7yoilsho	3326	3	of	of	IN
cord-006229-7yoilsho	3326	4	combustion	combustion	NN
cord-006229-7yoilsho	3326	5	processes	process	NNS
cord-006229-7yoilsho	3326	6	enhances	enhance	VBZ
cord-006229-7yoilsho	3326	7	cardio	cardio	JJ
cord-006229-7yoilsho	3326	8	-	-	HYPH
cord-006229-7yoilsho	3326	9	vascular	vascular	JJ
cord-006229-7yoilsho	3326	10	diseases	disease	NNS
cord-006229-7yoilsho	3326	11	and	and	CC
cord-006229-7yoilsho	3326	12	increases	increase	NNS
cord-006229-7yoilsho	3326	13	associated	associate	VBN
cord-006229-7yoilsho	3326	14	mortality	mortality	NN
cord-006229-7yoilsho	3326	15	rates	rate	NNS
cord-006229-7yoilsho	3326	16	.	.	.
cord-006229-7yoilsho	3327	1	Around	around	IN
cord-006229-7yoilsho	3327	2	13	13	CD
cord-006229-7yoilsho	3327	3	%	%	NN
cord-006229-7yoilsho	3327	4	of	of	IN
cord-006229-7yoilsho	3327	5	total	total	JJ
cord-006229-7yoilsho	3327	6	PM10	pm10	JJ
cord-006229-7yoilsho	3327	7	emissions	emission	NNS
cord-006229-7yoilsho	3327	8	are	be	VBP
cord-006229-7yoilsho	3327	9	emitted	emit	VBN
cord-006229-7yoilsho	3327	10	by	by	IN
cord-006229-7yoilsho	3327	11	wood	wood	NN
cord-006229-7yoilsho	3327	12	burners	burner	NNS
cord-006229-7yoilsho	3327	13	(	(	-LRB-
cord-006229-7yoilsho	3327	14	UBA	UBA	NNP
cord-006229-7yoilsho	3327	15	2006	2006	CD
cord-006229-7yoilsho	3327	16	)	)	-RRB-
cord-006229-7yoilsho	3327	17	.	.	.
cord-006229-7yoilsho	3328	1	How	how	WRB
cord-006229-7yoilsho	3328	2	wood	wood	NN
cord-006229-7yoilsho	3328	3	combustion	combustion	NN
cord-006229-7yoilsho	3328	4	aerosols	aerosol	NNS
cord-006229-7yoilsho	3328	5	(	(	-LRB-
cord-006229-7yoilsho	3328	6	particles	particle	NNS
cord-006229-7yoilsho	3328	7	and	and	CC
cord-006229-7yoilsho	3328	8	gasses	gas	NNS
cord-006229-7yoilsho	3328	9	)	)	-RRB-
cord-006229-7yoilsho	3328	10	can	can	MD
cord-006229-7yoilsho	3328	11	affect	affect	VB
cord-006229-7yoilsho	3328	12	human	human	JJ
cord-006229-7yoilsho	3328	13	lung	lung	NN
cord-006229-7yoilsho	3328	14	cells	cell	NNS
cord-006229-7yoilsho	3328	15	and	and	CC
cord-006229-7yoilsho	3328	16	how	how	WRB
cord-006229-7yoilsho	3328	17	such	such	JJ
cord-006229-7yoilsho	3328	18	cellular	cellular	JJ
cord-006229-7yoilsho	3328	19	responses	response	NNS
cord-006229-7yoilsho	3328	20	depend	depend	VBP
cord-006229-7yoilsho	3328	21	on	on	IN
cord-006229-7yoilsho	3328	22	the	the	DT
cord-006229-7yoilsho	3328	23	usage	usage	NN
cord-006229-7yoilsho	3328	24	of	of	IN
cord-006229-7yoilsho	3328	25	different	different	JJ
cord-006229-7yoilsho	3328	26	wood	wood	NN
cord-006229-7yoilsho	3328	27	types	type	NNS
cord-006229-7yoilsho	3328	28	and	and	CC
cord-006229-7yoilsho	3328	29	burners	burner	NNS
cord-006229-7yoilsho	3328	30	is	be	VBZ
cord-006229-7yoilsho	3328	31	widely	widely	RB
cord-006229-7yoilsho	3328	32	unknown	unknown	JJ
cord-006229-7yoilsho	3328	33	.	.	.
cord-006229-7yoilsho	3329	1	Methods	method	NNS
cord-006229-7yoilsho	3329	2	:	:	:
cord-006229-7yoilsho	3329	3	In	in	IN
cord-006229-7yoilsho	3329	4	an	an	DT
cord-006229-7yoilsho	3329	5	exposure	exposure	NN
cord-006229-7yoilsho	3329	6	chamber	chamber	NN
cord-006229-7yoilsho	3329	7	imitating	imitate	VBG
cord-006229-7yoilsho	3329	8	the	the	DT
cord-006229-7yoilsho	3329	9	human	human	JJ
cord-006229-7yoilsho	3329	10	respiratory	respiratory	JJ
cord-006229-7yoilsho	3329	11	tract	tract	NN
cord-006229-7yoilsho	3329	12	human	human	JJ
cord-006229-7yoilsho	3329	13	alveolar	alveolar	NN
cord-006229-7yoilsho	3329	14	cells	cell	NNS
cord-006229-7yoilsho	3329	15	(	(	-LRB-
cord-006229-7yoilsho	3329	16	A549	A549	NNP
cord-006229-7yoilsho	3329	17	)	)	-RRB-
cord-006229-7yoilsho	3329	18	were	be	VBD
cord-006229-7yoilsho	3329	19	exposed	expose	VBN
cord-006229-7yoilsho	3329	20	at	at	IN
cord-006229-7yoilsho	3329	21	an	an	DT
cord-006229-7yoilsho	3329	22	air	air	NN
cord-006229-7yoilsho	3329	23	-	-	HYPH
cord-006229-7yoilsho	3329	24	liquid	liquid	NN
cord-006229-7yoilsho	3329	25	-	-	HYPH
cord-006229-7yoilsho	3329	26	interface	interface	NN
cord-006229-7yoilsho	3329	27	(	(	-LRB-
cord-006229-7yoilsho	3329	28	ALI	ALI	NNP
cord-006229-7yoilsho	3329	29	)	)	-RRB-
cord-006229-7yoilsho	3329	30	to	to	IN
cord-006229-7yoilsho	3329	31	gasses	gas	NNS
cord-006229-7yoilsho	3329	32	and	and	CC
cord-006229-7yoilsho	3329	33	particles	particle	NNS
cord-006229-7yoilsho	3329	34	of	of	IN
cord-006229-7yoilsho	3329	35	wood	wood	NN
cord-006229-7yoilsho	3329	36	combustion	combustion	NN
cord-006229-7yoilsho	3329	37	aerosols	aerosol	NNS
cord-006229-7yoilsho	3329	38	.	.	.
cord-006229-7yoilsho	3330	1	Log	log	JJ
cord-006229-7yoilsho	3330	2	wood	wood	NN
cord-006229-7yoilsho	3330	3	of	of	IN
cord-006229-7yoilsho	3330	4	beech	beech	NN
cord-006229-7yoilsho	3330	5	,	,	,
cord-006229-7yoilsho	3330	6	birch	birch	NN
cord-006229-7yoilsho	3330	7	and	and	CC
cord-006229-7yoilsho	3330	8	spruce	spruce	NN
cord-006229-7yoilsho	3330	9	was	be	VBD
cord-006229-7yoilsho	3330	10	burnt	burn	VBN
cord-006229-7yoilsho	3330	11	in	in	IN
cord-006229-7yoilsho	3330	12	a	a	DT
cord-006229-7yoilsho	3330	13	conventional	conventional	JJ
cord-006229-7yoilsho	3330	14	oven	oven	NN
cord-006229-7yoilsho	3330	15	and	and	CC
cord-006229-7yoilsho	3330	16	compared	compare	VBN
cord-006229-7yoilsho	3330	17	to	to	IN
cord-006229-7yoilsho	3330	18	the	the	DT
cord-006229-7yoilsho	3330	19	combustion	combustion	NN
cord-006229-7yoilsho	3330	20	of	of	IN
cord-006229-7yoilsho	3330	21	wood	wood	NN
cord-006229-7yoilsho	3330	22	pellets	pellet	NNS
cord-006229-7yoilsho	3330	23	in	in	IN
cord-006229-7yoilsho	3330	24	a	a	DT
cord-006229-7yoilsho	3330	25	modern	modern	JJ
cord-006229-7yoilsho	3330	26	pellet	pellet	NN
cord-006229-7yoilsho	3330	27	burner	burner	NN
cord-006229-7yoilsho	3330	28	.	.	.
cord-006229-7yoilsho	3331	1	The	the	DT
cord-006229-7yoilsho	3331	2	combustion	combustion	NN
cord-006229-7yoilsho	3331	3	aerosols	aerosol	NNS
cord-006229-7yoilsho	3331	4	were	be	VBD
cord-006229-7yoilsho	3331	5	diluted	dilute	VBN
cord-006229-7yoilsho	3331	6	1:40	1:40	CD
cord-006229-7yoilsho	3331	7	and	and	CC
cord-006229-7yoilsho	3331	8	directly	directly	RB
cord-006229-7yoilsho	3331	9	delivered	deliver	VBN
cord-006229-7yoilsho	3331	10	to	to	IN
cord-006229-7yoilsho	3331	11	the	the	DT
cord-006229-7yoilsho	3331	12	exposure	exposure	NN
cord-006229-7yoilsho	3331	13	chamber	chamber	NN
cord-006229-7yoilsho	3331	14	.	.	.
cord-006229-7yoilsho	3332	1	After	after	IN
cord-006229-7yoilsho	3332	2	4h	4h	CD
cord-006229-7yoilsho	3332	3	exposure	exposure	NN
cord-006229-7yoilsho	3332	4	the	the	DT
cord-006229-7yoilsho	3332	5	lung	lung	NN
cord-006229-7yoilsho	3332	6	cells	cell	NNS
cord-006229-7yoilsho	3332	7	were	be	VBD
cord-006229-7yoilsho	3332	8	lysed	lyse	VBN
cord-006229-7yoilsho	3332	9	and	and	CC
cord-006229-7yoilsho	3332	10	RNA	RNA	NNP
cord-006229-7yoilsho	3332	11	was	be	VBD
cord-006229-7yoilsho	3332	12	isolated	isolate	VBN
cord-006229-7yoilsho	3332	13	.	.	.
cord-006229-7yoilsho	3333	1	In	in	IN
cord-006229-7yoilsho	3333	2	an	an	DT
cord-006229-7yoilsho	3333	3	array	array	NN
cord-006229-7yoilsho	3333	4	based	base	VBN
cord-006229-7yoilsho	3333	5	transcription	transcription	NN
cord-006229-7yoilsho	3333	6	analysis	analysis	NN
cord-006229-7yoilsho	3333	7	of	of	IN
cord-006229-7yoilsho	3333	8	the	the	DT
cord-006229-7yoilsho	3333	9	whole	whole	JJ
cord-006229-7yoilsho	3333	10	genome	genome	NN
cord-006229-7yoilsho	3333	11	the	the	DT
cord-006229-7yoilsho	3333	12	effects	effect	NNS
cord-006229-7yoilsho	3333	13	of	of	IN
cord-006229-7yoilsho	3333	14	the	the	DT
cord-006229-7yoilsho	3333	15	aerosol	aerosol	NN
cord-006229-7yoilsho	3333	16	exposures	exposure	NNS
cord-006229-7yoilsho	3333	17	on	on	IN
cord-006229-7yoilsho	3333	18	lung	lung	NN
cord-006229-7yoilsho	3333	19	cells	cell	NNS
cord-006229-7yoilsho	3333	20	was	be	VBD
cord-006229-7yoilsho	3333	21	assessed	assess	VBN
cord-006229-7yoilsho	3333	22	.	.	.
cord-006229-7yoilsho	3334	1	In	in	IN
cord-006229-7yoilsho	3334	2	parallel	parallel	JJ
cord-006229-7yoilsho	3334	3	,	,	,
cord-006229-7yoilsho	3334	4	physical	physical	JJ
cord-006229-7yoilsho	3334	5	and	and	CC
cord-006229-7yoilsho	3334	6	chemical	chemical	JJ
cord-006229-7yoilsho	3334	7	parameters	parameter	NNS
cord-006229-7yoilsho	3334	8	of	of	IN
cord-006229-7yoilsho	3334	9	the	the	DT
cord-006229-7yoilsho	3334	10	combustion	combustion	NN
cord-006229-7yoilsho	3334	11	aerosols	aerosol	NNS
cord-006229-7yoilsho	3334	12	were	be	VBD
cord-006229-7yoilsho	3334	13	analyzed	analyze	VBN
cord-006229-7yoilsho	3334	14	.	.	.
cord-006229-7yoilsho	3335	1	Results	result	NNS
cord-006229-7yoilsho	3335	2	:	:	:
cord-006229-7yoilsho	3336	1	The	the	DT
cord-006229-7yoilsho	3336	2	combustion	combustion	NN
cord-006229-7yoilsho	3336	3	aerosol	aerosol	NN
cord-006229-7yoilsho	3336	4	of	of	IN
cord-006229-7yoilsho	3336	5	wood	wood	NN
cord-006229-7yoilsho	3336	6	pellets	pellet	NNS
cord-006229-7yoilsho	3336	7	contained	contain	VBD
cord-006229-7yoilsho	3336	8	less	less	JJR
cord-006229-7yoilsho	3336	9	organic	organic	JJ
cord-006229-7yoilsho	3336	10	substances	substance	NNS
cord-006229-7yoilsho	3336	11	than	than	IN
cord-006229-7yoilsho	3336	12	the	the	DT
cord-006229-7yoilsho	3336	13	log	log	NN
cord-006229-7yoilsho	3336	14	wood	wood	NN
cord-006229-7yoilsho	3336	15	aerosols	aerosol	NNS
cord-006229-7yoilsho	3336	16	,	,	,
cord-006229-7yoilsho	3336	17	but	but	CC
cord-006229-7yoilsho	3336	18	was	be	VBD
cord-006229-7yoilsho	3336	19	higher	high	JJR
cord-006229-7yoilsho	3336	20	in	in	IN
cord-006229-7yoilsho	3336	21	its	-PRON-	PRP$
cord-006229-7yoilsho	3336	22	zinc	zinc	NN
cord-006229-7yoilsho	3336	23	content	content	NN
cord-006229-7yoilsho	3336	24	.	.	.
cord-006229-7yoilsho	3337	1	Genome	genome	NN
cord-006229-7yoilsho	3337	2	-	-	HYPH
cord-006229-7yoilsho	3337	3	wide	wide	RB
cord-006229-7yoilsho	3337	4	we	-PRON-	PRP
cord-006229-7yoilsho	3337	5	found	find	VBD
cord-006229-7yoilsho	3337	6	a	a	DT
cord-006229-7yoilsho	3337	7	higher	high	JJR
cord-006229-7yoilsho	3337	8	number	number	NN
cord-006229-7yoilsho	3337	9	of	of	IN
cord-006229-7yoilsho	3337	10	regulated	regulate	VBN
cord-006229-7yoilsho	3337	11	genes	gene	NNS
cord-006229-7yoilsho	3337	12	with	with	IN
cord-006229-7yoilsho	3337	13	combustion	combustion	NN
cord-006229-7yoilsho	3337	14	of	of	IN
cord-006229-7yoilsho	3337	15	pellets	pellet	NNS
cord-006229-7yoilsho	3337	16	compared	compare	VBN
cord-006229-7yoilsho	3337	17	to	to	IN
cord-006229-7yoilsho	3337	18	combustion	combustion	NN
cord-006229-7yoilsho	3337	19	of	of	IN
cord-006229-7yoilsho	3337	20	log	log	JJ
cord-006229-7yoilsho	3337	21	wood	wood	NN
cord-006229-7yoilsho	3337	22	.	.	.
cord-006229-7yoilsho	3338	1	The	the	DT
cord-006229-7yoilsho	3338	2	gas	gas	NN
cord-006229-7yoilsho	3338	3	phase	phase	NN
cord-006229-7yoilsho	3338	4	alone	alone	RB
cord-006229-7yoilsho	3338	5	(	(	-LRB-
cord-006229-7yoilsho	3338	6	filtered	filter	VBN
cord-006229-7yoilsho	3338	7	aerosol	aerosol	NN
cord-006229-7yoilsho	3338	8	)	)	-RRB-
cord-006229-7yoilsho	3338	9	showed	show	VBD
cord-006229-7yoilsho	3338	10	comparable	comparable	JJ
cord-006229-7yoilsho	3338	11	gene	gene	NN
cord-006229-7yoilsho	3338	12	regulatory	regulatory	JJ
cord-006229-7yoilsho	3338	13	activity	activity	NN
cord-006229-7yoilsho	3338	14	as	as	IN
cord-006229-7yoilsho	3338	15	the	the	DT
cord-006229-7yoilsho	3338	16	particle	particle	NN
cord-006229-7yoilsho	3338	17	-	-	HYPH
cord-006229-7yoilsho	3338	18	containing	contain	VBG
cord-006229-7yoilsho	3338	19	total	total	JJ
cord-006229-7yoilsho	3338	20	aerosol	aerosol	NN
cord-006229-7yoilsho	3338	21	.	.	.
cord-006229-7yoilsho	3339	1	Aerosol	aerosol	NN
cord-006229-7yoilsho	3339	2	from	from	IN
cord-006229-7yoilsho	3339	3	log	log	JJ
cord-006229-7yoilsho	3339	4	wood	wood	NN
cord-006229-7yoilsho	3339	5	burning	burning	NN
cord-006229-7yoilsho	3339	6	induced	induce	VBN
cord-006229-7yoilsho	3339	7	mainly	mainly	RB
cord-006229-7yoilsho	3339	8	genes	gene	NNS
cord-006229-7yoilsho	3339	9	of	of	IN
cord-006229-7yoilsho	3339	10	the	the	DT
cord-006229-7yoilsho	3339	11	xenobiotic	xenobiotic	JJ
cord-006229-7yoilsho	3339	12	metabolism	metabolism	NN
cord-006229-7yoilsho	3339	13	and	and	CC
cord-006229-7yoilsho	3339	14	cellular	cellular	JJ
cord-006229-7yoilsho	3339	15	signaling	signaling	NN
cord-006229-7yoilsho	3339	16	.	.	.
cord-006229-7yoilsho	3340	1	Pellet	pellet	NN
cord-006229-7yoilsho	3340	2	aerosols	aerosol	NNS
cord-006229-7yoilsho	3340	3	additionally	additionally	RB
cord-006229-7yoilsho	3340	4	regulated	regulate	VBD
cord-006229-7yoilsho	3340	5	apoptosis	apoptosis	NN
cord-006229-7yoilsho	3340	6	and	and	CC
cord-006229-7yoilsho	3340	7	DNA	dna	NN
cord-006229-7yoilsho	3340	8	repair	repair	NN
cord-006229-7yoilsho	3340	9	processes	process	NNS
cord-006229-7yoilsho	3340	10	.	.	.
cord-006229-7yoilsho	3341	1	Conclusions	conclusion	NNS
cord-006229-7yoilsho	3341	2	:	:	:
cord-006229-7yoilsho	3342	1	Modern	modern	JJ
cord-006229-7yoilsho	3342	2	pellet	pellet	NN
cord-006229-7yoilsho	3342	3	burners	burner	NNS
cord-006229-7yoilsho	3342	4	reach	reach	VBP
cord-006229-7yoilsho	3342	5	better	well	JJR
cord-006229-7yoilsho	3342	6	combustion	combustion	NN
cord-006229-7yoilsho	3342	7	efficiencies	efficiency	NNS
cord-006229-7yoilsho	3342	8	than	than	IN
cord-006229-7yoilsho	3342	9	conventional	conventional	JJ
cord-006229-7yoilsho	3342	10	log	log	NN
cord-006229-7yoilsho	3342	11	wood	wood	NN
cord-006229-7yoilsho	3342	12	ovens	oven	NNS
cord-006229-7yoilsho	3342	13	,	,	,
cord-006229-7yoilsho	3342	14	but	but	CC
cord-006229-7yoilsho	3342	15	their	-PRON-	PRP$
cord-006229-7yoilsho	3342	16	emissions	emission	NNS
cord-006229-7yoilsho	3342	17	seem	seem	VBP
cord-006229-7yoilsho	3342	18	to	to	TO
cord-006229-7yoilsho	3342	19	stress	stress	VB
cord-006229-7yoilsho	3342	20	human	human	JJ
cord-006229-7yoilsho	3342	21	lung	lung	NN
cord-006229-7yoilsho	3342	22	cells	cell	NNS
cord-006229-7yoilsho	3342	23	stronger	strong	JJR
cord-006229-7yoilsho	3342	24	.	.	.
cord-006229-7yoilsho	3343	1	One	one	CD
cord-006229-7yoilsho	3343	2	reason	reason	NN
cord-006229-7yoilsho	3343	3	might	may	MD
cord-006229-7yoilsho	3343	4	be	be	VB
cord-006229-7yoilsho	3343	5	the	the	DT
cord-006229-7yoilsho	3343	6	higher	high	JJR
cord-006229-7yoilsho	3343	7	zinc	zinc	NN
cord-006229-7yoilsho	3343	8	content	content	NN
cord-006229-7yoilsho	3343	9	of	of	IN
cord-006229-7yoilsho	3343	10	wood	wood	NN
cord-006229-7yoilsho	3343	11	pellet	pellet	NN
cord-006229-7yoilsho	3343	12	aerosols	aerosol	NNS
cord-006229-7yoilsho	3343	13	.	.	.
cord-006229-7yoilsho	3344	1	Multiwalled	multiwalled	JJ
cord-006229-7yoilsho	3344	2	carbon	carbon	NN
cord-006229-7yoilsho	3344	3	nanotubes	nanotube	NNS
cord-006229-7yoilsho	3344	4	(	(	-LRB-
cord-006229-7yoilsho	3344	5	MWCNTs	mwcnt	NNS
cord-006229-7yoilsho	3344	6	)	)	-RRB-
cord-006229-7yoilsho	3344	7	may	may	MD
cord-006229-7yoilsho	3344	8	pose	pose	VB
cord-006229-7yoilsho	3344	9	as	as	IN
cord-006229-7yoilsho	3344	10	a	a	DT
cord-006229-7yoilsho	3344	11	risk	risk	NN
cord-006229-7yoilsho	3344	12	similar	similar	JJ
cord-006229-7yoilsho	3344	13	to	to	IN
cord-006229-7yoilsho	3344	14	asbestos	asbestos	NN
cord-006229-7yoilsho	3344	15	in	in	IN
cord-006229-7yoilsho	3344	16	causing	cause	VBG
cord-006229-7yoilsho	3344	17	cancer	cancer	NN
cord-006229-7yoilsho	3344	18	,	,	,
cord-006229-7yoilsho	3344	19	notably	notably	RB
cord-006229-7yoilsho	3344	20	mesothelioma	mesothelioma	NN
cord-006229-7yoilsho	3344	21	,	,	,
cord-006229-7yoilsho	3344	22	which	which	WDT
cord-006229-7yoilsho	3344	23	is	be	VBZ
cord-006229-7yoilsho	3344	24	a	a	DT
cord-006229-7yoilsho	3344	25	malignant	malignant	JJ
cord-006229-7yoilsho	3344	26	tumor	tumor	NN
cord-006229-7yoilsho	3344	27	originating	originate	VBG
cord-006229-7yoilsho	3344	28	from	from	IN
cord-006229-7yoilsho	3344	29	mesothelial	mesothelial	JJ
cord-006229-7yoilsho	3344	30	cells	cell	NNS
cord-006229-7yoilsho	3344	31	.	.	.
cord-006229-7yoilsho	3345	1	To	to	TO
cord-006229-7yoilsho	3345	2	identify	identify	VB
cord-006229-7yoilsho	3345	3	molecular	molecular	JJ
cord-006229-7yoilsho	3345	4	cues	cue	NNS
cord-006229-7yoilsho	3345	5	leading	lead	VBG
cord-006229-7yoilsho	3345	6	to	to	IN
cord-006229-7yoilsho	3345	7	mesothelioma	mesothelioma	NN
cord-006229-7yoilsho	3345	8	development	development	NN
cord-006229-7yoilsho	3345	9	,	,	,
cord-006229-7yoilsho	3345	10	we	-PRON-	PRP
cord-006229-7yoilsho	3345	11	performed	perform	VBD
cord-006229-7yoilsho	3345	12	genome	genome	NN
cord-006229-7yoilsho	3345	13	-	-	HYPH
cord-006229-7yoilsho	3345	14	wide	wide	JJ
cord-006229-7yoilsho	3345	15	transcriptome	transcriptome	NN
cord-006229-7yoilsho	3345	16	analysis	analysis	NN
cord-006229-7yoilsho	3345	17	using	use	VBG
cord-006229-7yoilsho	3345	18	microarrays	microarray	NNS
cord-006229-7yoilsho	3345	19	in	in	IN
cord-006229-7yoilsho	3345	20	primary	primary	JJ
cord-006229-7yoilsho	3345	21	human	human	JJ
cord-006229-7yoilsho	3345	22	peritoneal	peritoneal	NN
cord-006229-7yoilsho	3345	23	mesothelial	mesothelial	JJ
cord-006229-7yoilsho	3345	24	LP9	LP9	NNP
cord-006229-7yoilsho	3345	25	cells	cell	NNS
cord-006229-7yoilsho	3345	26	treated	treat	VBN
cord-006229-7yoilsho	3345	27	with	with	IN
cord-006229-7yoilsho	3345	28	two	two	CD
cord-006229-7yoilsho	3345	29	different	different	JJ
cord-006229-7yoilsho	3345	30	tumor	tumor	NN
cord-006229-7yoilsho	3345	31	-	-	HYPH
cord-006229-7yoilsho	3345	32	inducing	induce	VBG
cord-006229-7yoilsho	3345	33	tailor	tailor	NN
cord-006229-7yoilsho	3345	34	-	-	HYPH
cord-006229-7yoilsho	3345	35	made	make	VBN
cord-006229-7yoilsho	3345	36	MWCNTs	MWCNTs	.
cord-006229-7yoilsho	3345	37	(	(	-LRB-
cord-006229-7yoilsho	3345	38	rat	rat	NN
cord-006229-7yoilsho	3345	39	model	model	NN
cord-006229-7yoilsho	3345	40	;	;	:
cord-006229-7yoilsho	3345	41	Rittinghausen	Rittinghausen	NNP
cord-006229-7yoilsho	3345	42	et	et	NNP
cord-006229-7yoilsho	3345	43	al	al	NNP
cord-006229-7yoilsho	3345	44	.	.	.
cord-006229-7yoilsho	3346	1	2014	2014	CD
cord-006229-7yoilsho	3347	1	Part	Part	NNP
cord-006229-7yoilsho	3347	2	Fibre	Fibre	NNP
cord-006229-7yoilsho	3347	3	Toxicol	Toxicol	NNP
cord-006229-7yoilsho	3347	4	11:59	11:59	CD
cord-006229-7yoilsho	3347	5	)	)	-RRB-
cord-006229-7yoilsho	3347	6	,	,	,
cord-006229-7yoilsho	3347	7	or	or	CC
cord-006229-7yoilsho	3347	8	amosite	amosite	JJ
cord-006229-7yoilsho	3347	9	asbestos	asbestos	NN
cord-006229-7yoilsho	3347	10	at	at	IN
cord-006229-7yoilsho	3347	11	3	3	CD
cord-006229-7yoilsho	3347	12	µg	µg	NN
cord-006229-7yoilsho	3347	13	/	/	SYM
cord-006229-7yoilsho	3347	14	cm2	cm2	NN
cord-006229-7yoilsho	3347	15	for	for	IN
cord-006229-7yoilsho	3347	16	24	24	CD
cord-006229-7yoilsho	3347	17	h.	h.	NN
cord-006229-7yoilsho	3348	1	Specifically	specifically	RB
cord-006229-7yoilsho	3348	2	,	,	,
cord-006229-7yoilsho	3348	3	we	-PRON-	PRP
cord-006229-7yoilsho	3348	4	determined	determine	VBD
cord-006229-7yoilsho	3348	5	how	how	WRB
cord-006229-7yoilsho	3348	6	the	the	DT
cord-006229-7yoilsho	3348	7	transcriptomic	transcriptomic	JJ
cord-006229-7yoilsho	3348	8	changes	change	NNS
cord-006229-7yoilsho	3348	9	of	of	IN
cord-006229-7yoilsho	3348	10	the	the	DT
cord-006229-7yoilsho	3348	11	highly	highly	RB
cord-006229-7yoilsho	3348	12	tumorigenic	tumorigenic	JJ
cord-006229-7yoilsho	3348	13	MWCNT	MWCNT	NNP
cord-006229-7yoilsho	3348	14	A	A	NNP
cord-006229-7yoilsho	3348	15	would	would	MD
cord-006229-7yoilsho	3348	16	differ	differ	VB
cord-006229-7yoilsho	3348	17	from	from	IN
cord-006229-7yoilsho	3348	18	another	another	DT
cord-006229-7yoilsho	3348	19	tumor	tumor	NN
cord-006229-7yoilsho	3348	20	-	-	HYPH
cord-006229-7yoilsho	3348	21	inducing	induce	VBG
cord-006229-7yoilsho	3348	22	MWCNT	MWCNT	NNP
cord-006229-7yoilsho	3348	23	with	with	IN
cord-006229-7yoilsho	3348	24	albeit	albeit	RB
cord-006229-7yoilsho	3348	25	lesser	less	JJR
cord-006229-7yoilsho	3348	26	potency	potency	NN
cord-006229-7yoilsho	3348	27	(	(	-LRB-
cord-006229-7yoilsho	3348	28	MWCNT	MWCNT	NNP
cord-006229-7yoilsho	3348	29	D	D	NNP
cord-006229-7yoilsho	3348	30	)	)	-RRB-
cord-006229-7yoilsho	3348	31	,	,	,
cord-006229-7yoilsho	3348	32	long	long	JJ
cord-006229-7yoilsho	3348	33	amosite	amosite	JJ
cord-006229-7yoilsho	3348	34	asbestos	asbestos	NN
cord-006229-7yoilsho	3348	35	as	as	IN
cord-006229-7yoilsho	3348	36	positive	positive	JJ
cord-006229-7yoilsho	3348	37	control	control	NN
cord-006229-7yoilsho	3348	38	,	,	,
cord-006229-7yoilsho	3348	39	and	and	CC
cord-006229-7yoilsho	3348	40	milled	mill	VBD
cord-006229-7yoilsho	3348	41	MWCNT	MWCNT	NNP
cord-006229-7yoilsho	3348	42	A	A	NNP
cord-006229-7yoilsho	3348	43	as	as	IN
cord-006229-7yoilsho	3348	44	material	material	NN
cord-006229-7yoilsho	3348	45	control	control	NN
cord-006229-7yoilsho	3348	46	.	.	.
cord-006229-7yoilsho	3349	1	Initial	initial	JJ
cord-006229-7yoilsho	3349	2	analysis	analysis	NN
cord-006229-7yoilsho	3349	3	using	use	VBG
cord-006229-7yoilsho	3349	4	bioinformatic	bioinformatic	JJ
cord-006229-7yoilsho	3349	5	tools	tool	NNS
cord-006229-7yoilsho	3349	6	,	,	,
cord-006229-7yoilsho	3349	7	revealed	reveal	VBD
cord-006229-7yoilsho	3349	8	3788	3788	CD
cord-006229-7yoilsho	3349	9	significantly	significantly	RB
cord-006229-7yoilsho	3349	10	differentially	differentially	RB
cord-006229-7yoilsho	3349	11	regulated	regulate	VBN
cord-006229-7yoilsho	3349	12	genes	gene	NNS
cord-006229-7yoilsho	3349	13	for	for	IN
cord-006229-7yoilsho	3349	14	MWCNT	MWCNT	NNP
cord-006229-7yoilsho	3349	15	A	A	NNP
cord-006229-7yoilsho	3349	16	,	,	,
cord-006229-7yoilsho	3349	17	1680	1680	CD
cord-006229-7yoilsho	3349	18	for	for	IN
cord-006229-7yoilsho	3349	19	MWCNT	MWCNT	NNP
cord-006229-7yoilsho	3349	20	D	D	NNP
cord-006229-7yoilsho	3349	21	,	,	,
cord-006229-7yoilsho	3349	22	145	145	CD
cord-006229-7yoilsho	3349	23	for	for	IN
cord-006229-7yoilsho	3349	24	amosite	amosite	NNP
cord-006229-7yoilsho	3349	25	,	,	,
cord-006229-7yoilsho	3349	26	and	and	CC
cord-006229-7yoilsho	3349	27	4	4	CD
cord-006229-7yoilsho	3349	28	for	for	IN
cord-006229-7yoilsho	3349	29	milled	mill	VBN
cord-006229-7yoilsho	3349	30	MWCNT	MWCNT	NNP
cord-006229-7yoilsho	3349	31	.	.	.
cord-006229-7yoilsho	3350	1	Further	further	JJ
cord-006229-7yoilsho	3350	2	analyses	analysis	NNS
cord-006229-7yoilsho	3350	3	with	with	IN
cord-006229-7yoilsho	3350	4	Ingenuity	Ingenuity	NNP
cord-006229-7yoilsho	3350	5	Pathway	Pathway	NNP
cord-006229-7yoilsho	3350	6	Analysis	Analysis	NNP
cord-006229-7yoilsho	3350	7	comparing	compare	VBG
cord-006229-7yoilsho	3350	8	the	the	DT
cord-006229-7yoilsho	3350	9	two	two	CD
cord-006229-7yoilsho	3350	10	different	different	JJ
cord-006229-7yoilsho	3350	11	MWCNT	MWCNT	NNP
cord-006229-7yoilsho	3350	12	types	type	NNS
cord-006229-7yoilsho	3350	13	and	and	CC
cord-006229-7yoilsho	3350	14	amosite	amosite	NNP
cord-006229-7yoilsho	3350	15	,	,	,
cord-006229-7yoilsho	3350	16	found	find	VBD
cord-006229-7yoilsho	3350	17	common	common	JJ
cord-006229-7yoilsho	3350	18	as	as	RB
cord-006229-7yoilsho	3350	19	well	well	RB
cord-006229-7yoilsho	3350	20	as	as	IN
cord-006229-7yoilsho	3350	21	exclusive	exclusive	JJ
cord-006229-7yoilsho	3350	22	biomarkers	biomarker	NNS
cord-006229-7yoilsho	3350	23	.	.	.
cord-006229-7yoilsho	3351	1	Interestingly	interestingly	RB
cord-006229-7yoilsho	3351	2	,	,	,
cord-006229-7yoilsho	3351	3	we	-PRON-	PRP
cord-006229-7yoilsho	3351	4	identified	identify	VBD
cord-006229-7yoilsho	3351	5	many	many	JJ
cord-006229-7yoilsho	3351	6	differentially	differentially	RB
cord-006229-7yoilsho	3351	7	regulated	regulate	VBN
cord-006229-7yoilsho	3351	8	genes	gene	NNS
cord-006229-7yoilsho	3351	9	implicated	implicate	VBN
cord-006229-7yoilsho	3351	10	in	in	IN
cord-006229-7yoilsho	3351	11	cellular	cellular	JJ
cord-006229-7yoilsho	3351	12	senescence	senescence	NN
cord-006229-7yoilsho	3351	13	,	,	,
cord-006229-7yoilsho	3351	14	a	a	DT
cord-006229-7yoilsho	3351	15	growth	growth	NN
cord-006229-7yoilsho	3351	16	arrest	arrest	NN
cord-006229-7yoilsho	3351	17	in	in	IN
cord-006229-7yoilsho	3351	18	response	response	NN
cord-006229-7yoilsho	3351	19	to	to	IN
cord-006229-7yoilsho	3351	20	different	different	JJ
cord-006229-7yoilsho	3351	21	stressors	stressor	NNS
cord-006229-7yoilsho	3351	22	including	include	VBG
cord-006229-7yoilsho	3351	23	DNA	dna	NN
cord-006229-7yoilsho	3351	24	damage	damage	NN
cord-006229-7yoilsho	3351	25	,	,	,
cord-006229-7yoilsho	3351	26	disrupted	disrupt	VBN
cord-006229-7yoilsho	3351	27	chromatin	chromatin	NN
cord-006229-7yoilsho	3351	28	,	,	,
cord-006229-7yoilsho	3351	29	and	and	CC
cord-006229-7yoilsho	3351	30	strong	strong	JJ
cord-006229-7yoilsho	3351	31	mitogenic	mitogenic	NNP
cord-006229-7yoilsho	3351	32	signals	signal	NNS
cord-006229-7yoilsho	3351	33	.	.	.
cord-006229-7yoilsho	3352	1	Paradoxically	paradoxically	RB
cord-006229-7yoilsho	3352	2	,	,	,
cord-006229-7yoilsho	3352	3	cellular	cellular	JJ
cord-006229-7yoilsho	3352	4	senescence	senescence	NN
cord-006229-7yoilsho	3352	5	can	can	MD
cord-006229-7yoilsho	3352	6	represent	represent	VB
cord-006229-7yoilsho	3352	7	both	both	DT
cord-006229-7yoilsho	3352	8	tumor	tumor	NN
cord-006229-7yoilsho	3352	9	suppression	suppression	NN
cord-006229-7yoilsho	3352	10	and	and	CC
cord-006229-7yoilsho	3352	11	tumor	tumor	NN
cord-006229-7yoilsho	3352	12	promotion	promotion	NN
cord-006229-7yoilsho	3352	13	mechanisms	mechanism	NNS
cord-006229-7yoilsho	3352	14	.	.	.
cord-006229-7yoilsho	3353	1	More	more	RBR
cord-006229-7yoilsho	3353	2	important	important	JJ
cord-006229-7yoilsho	3353	3	,	,	,
cord-006229-7yoilsho	3353	4	we	-PRON-	PRP
cord-006229-7yoilsho	3353	5	found	find	VBD
cord-006229-7yoilsho	3353	6	differential	differential	JJ
cord-006229-7yoilsho	3353	7	expression	expression	NN
cord-006229-7yoilsho	3353	8	of	of	IN
cord-006229-7yoilsho	3353	9	genes	gene	NNS
cord-006229-7yoilsho	3353	10	associated	associate	VBN
cord-006229-7yoilsho	3353	11	with	with	IN
cord-006229-7yoilsho	3353	12	senescence	senescence	NN
cord-006229-7yoilsho	3353	13	-	-	HYPH
cord-006229-7yoilsho	3353	14	associated	associate	VBN
cord-006229-7yoilsho	3353	15	secretory	secretory	JJ
cord-006229-7yoilsho	3353	16	phenotype	phenotype	NN
cord-006229-7yoilsho	3353	17	(	(	-LRB-
cord-006229-7yoilsho	3353	18	SASP	SASP	NNP
cord-006229-7yoilsho	3353	19	)	)	-RRB-
cord-006229-7yoilsho	3353	20	such	such	JJ
cord-006229-7yoilsho	3353	21	as	as	IN
cord-006229-7yoilsho	3353	22	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	3353	23	cytokines	cytokine	NNS
cord-006229-7yoilsho	3353	24	,	,	,
cord-006229-7yoilsho	3353	25	chemokines	chemokine	NNS
cord-006229-7yoilsho	3353	26	,	,	,
cord-006229-7yoilsho	3353	27	proteases	protease	NNS
cord-006229-7yoilsho	3353	28	,	,	,
cord-006229-7yoilsho	3353	29	and	and	CC
cord-006229-7yoilsho	3353	30	growth	growth	NN
cord-006229-7yoilsho	3353	31	factors	factor	NNS
cord-006229-7yoilsho	3353	32	,	,	,
cord-006229-7yoilsho	3353	33	which	which	WDT
cord-006229-7yoilsho	3353	34	were	be	VBD
cord-006229-7yoilsho	3353	35	manyfolds	manyfolds	NNP
cord-006229-7yoilsho	3353	36	up	up	RB
cord-006229-7yoilsho	3353	37	-	-	:
cord-006229-7yoilsho	3353	38	and	and	CC
cord-006229-7yoilsho	3353	39	down	down	RB
cord-006229-7yoilsho	3353	40	-	-	HYPH
cord-006229-7yoilsho	3353	41	regulated	regulate	VBN
cord-006229-7yoilsho	3353	42	in	in	IN
cord-006229-7yoilsho	3353	43	MWCNT	MWCNT	NNP
cord-006229-7yoilsho	3353	44	A	A	NNP
cord-006229-7yoilsho	3353	45	,	,	,
cord-006229-7yoilsho	3353	46	compared	compare	VBN
cord-006229-7yoilsho	3353	47	to	to	IN
cord-006229-7yoilsho	3353	48	MWCNT	MWCNT	NNP
cord-006229-7yoilsho	3353	49	D	D	NNP
cord-006229-7yoilsho	3353	50	and	and	CC
cord-006229-7yoilsho	3353	51	amosite	amosite	NNP
cord-006229-7yoilsho	3353	52	.	.	.
cord-006229-7yoilsho	3354	1	The	the	DT
cord-006229-7yoilsho	3354	2	mechanisms	mechanism	NNS
cord-006229-7yoilsho	3354	3	leading	lead	VBG
cord-006229-7yoilsho	3354	4	to	to	IN
cord-006229-7yoilsho	3354	5	mesothelioma	mesothelioma	NN
cord-006229-7yoilsho	3354	6	induction	induction	NN
cord-006229-7yoilsho	3354	7	by	by	IN
cord-006229-7yoilsho	3354	8	MWCNTs	mwcnt	NNS
cord-006229-7yoilsho	3354	9	are	be	VBP
cord-006229-7yoilsho	3354	10	from	from	IN
cord-006229-7yoilsho	3354	11	far	far	RB
cord-006229-7yoilsho	3354	12	clear	clear	JJ
cord-006229-7yoilsho	3354	13	,	,	,
cord-006229-7yoilsho	3354	14	but	but	CC
cord-006229-7yoilsho	3354	15	the	the	DT
cord-006229-7yoilsho	3354	16	key	key	JJ
cord-006229-7yoilsho	3354	17	information	information	NN
cord-006229-7yoilsho	3354	18	emerging	emerge	VBG
cord-006229-7yoilsho	3354	19	from	from	IN
cord-006229-7yoilsho	3354	20	the	the	DT
cord-006229-7yoilsho	3354	21	present	present	JJ
cord-006229-7yoilsho	3354	22	transcriptomic	transcriptomic	JJ
cord-006229-7yoilsho	3354	23	data	datum	NNS
cord-006229-7yoilsho	3354	24	,	,	,
cord-006229-7yoilsho	3354	25	together	together	RB
cord-006229-7yoilsho	3354	26	with	with	IN
cord-006229-7yoilsho	3354	27	our	-PRON-	PRP$
cord-006229-7yoilsho	3354	28	previously	previously	RB
cord-006229-7yoilsho	3354	29	identified	identify	VBN
cord-006229-7yoilsho	3354	30	senescence	senescence	NN
cord-006229-7yoilsho	3354	31	markers	marker	NNS
cord-006229-7yoilsho	3354	32	,	,	,
cord-006229-7yoilsho	3354	33	indicate	indicate	VBP
cord-006229-7yoilsho	3354	34	that	that	IN
cord-006229-7yoilsho	3354	35	cellular	cellular	JJ
cord-006229-7yoilsho	3354	36	senescence	senescence	NN
cord-006229-7yoilsho	3354	37	has	have	VBZ
cord-006229-7yoilsho	3354	38	a	a	DT
cord-006229-7yoilsho	3354	39	likely	likely	JJ
cord-006229-7yoilsho	3354	40	role	role	NN
cord-006229-7yoilsho	3354	41	.	.	.
cord-006229-7yoilsho	3355	1	Nanotechnology	nanotechnology	NN
cord-006229-7yoilsho	3355	2	offers	offer	VBZ
cord-006229-7yoilsho	3355	3	great	great	JJ
cord-006229-7yoilsho	3355	4	advantages	advantage	NNS
cord-006229-7yoilsho	3355	5	for	for	IN
cord-006229-7yoilsho	3355	6	the	the	DT
cord-006229-7yoilsho	3355	7	food	food	NN
cord-006229-7yoilsho	3355	8	industry	industry	NN
cord-006229-7yoilsho	3355	9	despite	despite	IN
cord-006229-7yoilsho	3355	10	its	-PRON-	PRP$
cord-006229-7yoilsho	3355	11	partly	partly	RB
cord-006229-7yoilsho	3355	12	unknown	unknown	JJ
cord-006229-7yoilsho	3355	13	risks	risk	NNS
cord-006229-7yoilsho	3355	14	,	,	,
cord-006229-7yoilsho	3355	15	whose	whose	WP$
cord-006229-7yoilsho	3355	16	enlightenment	enlightenment	NN
cord-006229-7yoilsho	3355	17	is	be	VBZ
cord-006229-7yoilsho	3355	18	the	the	DT
cord-006229-7yoilsho	3355	19	main	main	JJ
cord-006229-7yoilsho	3355	20	target	target	NN
cord-006229-7yoilsho	3355	21	of	of	IN
cord-006229-7yoilsho	3355	22	nanotoxicology	nanotoxicology	NN
cord-006229-7yoilsho	3355	23	.	.	.
cord-006229-7yoilsho	3356	1	Due	due	IN
cord-006229-7yoilsho	3356	2	to	to	IN
cord-006229-7yoilsho	3356	3	variability	variability	NN
cord-006229-7yoilsho	3356	4	in	in	IN
cord-006229-7yoilsho	3356	5	terms	term	NNS
cord-006229-7yoilsho	3356	6	of	of	IN
cord-006229-7yoilsho	3356	7	size	size	NN
cord-006229-7yoilsho	3356	8	,	,	,
cord-006229-7yoilsho	3356	9	material	material	NN
cord-006229-7yoilsho	3356	10	,	,	,
cord-006229-7yoilsho	3356	11	shape	shape	NN
cord-006229-7yoilsho	3356	12	,	,	,
cord-006229-7yoilsho	3356	13	surface	surface	NN
cord-006229-7yoilsho	3356	14	texture	texture	NN
cord-006229-7yoilsho	3356	15	and	and	CC
cord-006229-7yoilsho	3356	16	several	several	JJ
cord-006229-7yoilsho	3356	17	endogenous	endogenous	JJ
cord-006229-7yoilsho	3356	18	influences	influence	NNS
cord-006229-7yoilsho	3356	19	,	,	,
cord-006229-7yoilsho	3356	20	the	the	DT
cord-006229-7yoilsho	3356	21	toxicity	toxicity	NN
cord-006229-7yoilsho	3356	22	of	of	IN
cord-006229-7yoilsho	3356	23	most	most	RBS
cord-006229-7yoilsho	3356	24	frequently	frequently	RB
cord-006229-7yoilsho	3356	25	used	use	VBN
cord-006229-7yoilsho	3356	26	and	and	CC
cord-006229-7yoilsho	3356	27	ingested	ingest	VBN
cord-006229-7yoilsho	3356	28	nanomaterials	nanomaterial	NNS
cord-006229-7yoilsho	3356	29	is	be	VBZ
cord-006229-7yoilsho	3356	30	difficult	difficult	JJ
cord-006229-7yoilsho	3356	31	to	to	TO
cord-006229-7yoilsho	3356	32	estimate	estimate	VB
cord-006229-7yoilsho	3356	33	.	.	.
cord-006229-7yoilsho	3357	1	Therefore	therefore	RB
cord-006229-7yoilsho	3357	2	,	,	,
cord-006229-7yoilsho	3357	3	the	the	DT
cord-006229-7yoilsho	3357	4	aim	aim	NN
cord-006229-7yoilsho	3357	5	of	of	IN
cord-006229-7yoilsho	3357	6	this	this	DT
cord-006229-7yoilsho	3357	7	study	study	NN
cord-006229-7yoilsho	3357	8	was	be	VBD
cord-006229-7yoilsho	3357	9	the	the	DT
cord-006229-7yoilsho	3357	10	in	in	FW
cord-006229-7yoilsho	3357	11	vitro	vitro	FW
cord-006229-7yoilsho	3357	12	investigation	investigation	NN
cord-006229-7yoilsho	3357	13	of	of	IN
cord-006229-7yoilsho	3357	14	toxicological	toxicological	JJ
cord-006229-7yoilsho	3357	15	endpoints	endpoint	NNS
cord-006229-7yoilsho	3357	16	such	such	JJ
cord-006229-7yoilsho	3357	17	as	as	IN
cord-006229-7yoilsho	3357	18	cell	cell	NN
cord-006229-7yoilsho	3357	19	viability	viability	NN
cord-006229-7yoilsho	3357	20	,	,	,
cord-006229-7yoilsho	3357	21	DNA	dna	NN
cord-006229-7yoilsho	3357	22	integrity	integrity	NN
cord-006229-7yoilsho	3357	23	and	and	CC
cord-006229-7yoilsho	3357	24	the	the	DT
cord-006229-7yoilsho	3357	25	induction	induction	NN
cord-006229-7yoilsho	3357	26	of	of	IN
cord-006229-7yoilsho	3357	27	apoptotic	apoptotic	JJ
cord-006229-7yoilsho	3357	28	processes	process	NNS
cord-006229-7yoilsho	3357	29	in	in	IN
cord-006229-7yoilsho	3357	30	human	human	JJ
cord-006229-7yoilsho	3357	31	colon	colon	NN
cord-006229-7yoilsho	3357	32	carcinoma	carcinoma	NN
cord-006229-7yoilsho	3357	33	cells	cell	NNS
cord-006229-7yoilsho	3357	34	(	(	-LRB-
cord-006229-7yoilsho	3357	35	HT29	HT29	NNP
cord-006229-7yoilsho	3357	36	)	)	-RRB-
cord-006229-7yoilsho	3357	37	.	.	.
cord-006229-7yoilsho	3358	1	For	for	IN
cord-006229-7yoilsho	3358	2	this	this	DT
cord-006229-7yoilsho	3358	3	purpose	purpose	NN
cord-006229-7yoilsho	3358	4	HT29	HT29	NNP
cord-006229-7yoilsho	3358	5	cells	cell	NNS
cord-006229-7yoilsho	3358	6	were	be	VBD
cord-006229-7yoilsho	3358	7	exposed	expose	VBN
cord-006229-7yoilsho	3358	8	for	for	IN
cord-006229-7yoilsho	3358	9	24	24	CD
cord-006229-7yoilsho	3358	10	hours	hour	NNS
cord-006229-7yoilsho	3358	11	with	with	IN
cord-006229-7yoilsho	3358	12	metal	metal	NN
cord-006229-7yoilsho	3358	13	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	3358	14	(	(	-LRB-
cord-006229-7yoilsho	3358	15	gold	gold	NN
cord-006229-7yoilsho	3358	16	,	,	,
cord-006229-7yoilsho	3358	17	silver	silver	NN
cord-006229-7yoilsho	3358	18	)	)	-RRB-
cord-006229-7yoilsho	3358	19	and	and	CC
cord-006229-7yoilsho	3358	20	metal	metal	NN
cord-006229-7yoilsho	3358	21	oxide	oxide	NN
cord-006229-7yoilsho	3358	22	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	3358	23	(	(	-LRB-
cord-006229-7yoilsho	3358	24	copper	copper	NN
cord-006229-7yoilsho	3358	25	oxide	oxide	NN
cord-006229-7yoilsho	3358	26	,	,	,
cord-006229-7yoilsho	3358	27	titanium	titanium	NN
cord-006229-7yoilsho	3358	28	dioxide	dioxide	NN
cord-006229-7yoilsho	3358	29	,	,	,
cord-006229-7yoilsho	3358	30	zinc	zinc	NN
cord-006229-7yoilsho	3358	31	oxide	oxide	NN
cord-006229-7yoilsho	3358	32	)	)	-RRB-
cord-006229-7yoilsho	3358	33	in	in	IN
cord-006229-7yoilsho	3358	34	concentrations	concentration	NNS
cord-006229-7yoilsho	3358	35	of	of	IN
cord-006229-7yoilsho	3358	36	2	2	CD
cord-006229-7yoilsho	3358	37	-	-	SYM
cord-006229-7yoilsho	3358	38	10	10	CD
cord-006229-7yoilsho	3358	39	µg	µg	NN
cord-006229-7yoilsho	3358	40	/	/	SYM
cord-006229-7yoilsho	3358	41	ml	ml	NN
cord-006229-7yoilsho	3358	42	.	.	.
cord-006229-7yoilsho	3359	1	At	at	IN
cord-006229-7yoilsho	3359	2	first	first	RB
cord-006229-7yoilsho	3359	3	the	the	DT
cord-006229-7yoilsho	3359	4	cellular	cellular	JJ
cord-006229-7yoilsho	3359	5	uptake	uptake	NN
cord-006229-7yoilsho	3359	6	of	of	IN
cord-006229-7yoilsho	3359	7	the	the	DT
cord-006229-7yoilsho	3359	8	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	3359	9	by	by	IN
cord-006229-7yoilsho	3359	10	means	mean	NNS
cord-006229-7yoilsho	3359	11	of	of	IN
cord-006229-7yoilsho	3359	12	an	an	DT
cord-006229-7yoilsho	3359	13	ICPMS	ICPMS	NNP
cord-006229-7yoilsho	3359	14	was	be	VBD
cord-006229-7yoilsho	3359	15	determined	determine	VBN
cord-006229-7yoilsho	3359	16	.	.	.
cord-006229-7yoilsho	3360	1	The	the	DT
cord-006229-7yoilsho	3360	2	influence	influence	NN
cord-006229-7yoilsho	3360	3	of	of	IN
cord-006229-7yoilsho	3360	4	cell	cell	NN
cord-006229-7yoilsho	3360	5	viability	viability	NN
cord-006229-7yoilsho	3360	6	was	be	VBD
cord-006229-7yoilsho	3360	7	demonstrated	demonstrate	VBN
cord-006229-7yoilsho	3360	8	by	by	IN
cord-006229-7yoilsho	3360	9	the	the	DT
cord-006229-7yoilsho	3360	10	trypan	trypan	NNP
cord-006229-7yoilsho	3360	11	blue	blue	JJ
cord-006229-7yoilsho	3360	12	staining	staining	NN
cord-006229-7yoilsho	3360	13	and	and	CC
cord-006229-7yoilsho	3360	14	the	the	DT
cord-006229-7yoilsho	3360	15	MTT	MTT	NNP
cord-006229-7yoilsho	3360	16	assay	assay	NN
cord-006229-7yoilsho	3360	17	.	.	.
cord-006229-7yoilsho	3361	1	The	the	DT
cord-006229-7yoilsho	3361	2	alkaline	alkaline	JJ
cord-006229-7yoilsho	3361	3	comet	comet	NN
cord-006229-7yoilsho	3361	4	assay	assay	NN
cord-006229-7yoilsho	3361	5	gave	give	VBD
cord-006229-7yoilsho	3361	6	information	information	NN
cord-006229-7yoilsho	3361	7	about	about	IN
cord-006229-7yoilsho	3361	8	possible	possible	JJ
cord-006229-7yoilsho	3361	9	DNA	dna	NN
cord-006229-7yoilsho	3361	10	damages	damage	NNS
cord-006229-7yoilsho	3361	11	and	and	CC
cord-006229-7yoilsho	3361	12	the	the	DT
cord-006229-7yoilsho	3361	13	use	use	NN
cord-006229-7yoilsho	3361	14	of	of	IN
cord-006229-7yoilsho	3361	15	the	the	DT
cord-006229-7yoilsho	3361	16	repair	repair	NN
cord-006229-7yoilsho	3361	17	enzyme	enzyme	NN
cord-006229-7yoilsho	3361	18	formamidopyrimidine	formamidopyrimidine	NN
cord-006229-7yoilsho	3361	19	DNA	DNA	NNP
cord-006229-7yoilsho	3361	20	glycosylase	glycosylase	NN
cord-006229-7yoilsho	3361	21	(	(	-LRB-
cord-006229-7yoilsho	3361	22	FPG	fpg	NN
cord-006229-7yoilsho	3361	23	)	)	-RRB-
cord-006229-7yoilsho	3361	24	additionally	additionally	RB
cord-006229-7yoilsho	3361	25	allowed	allow	VBD
cord-006229-7yoilsho	3361	26	the	the	DT
cord-006229-7yoilsho	3361	27	detection	detection	NN
cord-006229-7yoilsho	3361	28	of	of	IN
cord-006229-7yoilsho	3361	29	oxidized	oxidize	VBN
cord-006229-7yoilsho	3361	30	bases	basis	NNS
cord-006229-7yoilsho	3361	31	.	.	.
cord-006229-7yoilsho	3362	1	The	the	DT
cord-006229-7yoilsho	3362	2	induction	induction	NN
cord-006229-7yoilsho	3362	3	of	of	IN
cord-006229-7yoilsho	3362	4	programmed	programmed	JJ
cord-006229-7yoilsho	3362	5	cell	cell	NN
cord-006229-7yoilsho	3362	6	death	death	NN
cord-006229-7yoilsho	3362	7	was	be	VBD
cord-006229-7yoilsho	3362	8	examined	examine	VBN
cord-006229-7yoilsho	3362	9	using	use	VBG
cord-006229-7yoilsho	3362	10	by	by	IN
cord-006229-7yoilsho	3362	11	Annexin	Annexin	NNP
cord-006229-7yoilsho	3362	12	V	V	NNP
cord-006229-7yoilsho	3362	13	FITC	FITC	NNP
cord-006229-7yoilsho	3362	14	assay	assay	NN
cord-006229-7yoilsho	3362	15	.	.	.
cord-006229-7yoilsho	3363	1	The	the	DT
cord-006229-7yoilsho	3363	2	ICP	ICP	NNP
cord-006229-7yoilsho	3363	3	-	-	HYPH
cord-006229-7yoilsho	3363	4	MS	MS	NNP
cord-006229-7yoilsho	3363	5	data	datum	NNS
cord-006229-7yoilsho	3363	6	showed	show	VBD
cord-006229-7yoilsho	3363	7	a	a	DT
cord-006229-7yoilsho	3363	8	maximum	maximum	JJ
cord-006229-7yoilsho	3363	9	particle	particle	NN
cord-006229-7yoilsho	3363	10	content	content	NN
cord-006229-7yoilsho	3363	11	of	of	IN
cord-006229-7yoilsho	3363	12	1.39	1.39	CD
cord-006229-7yoilsho	3363	13	pg	pg	NN
cord-006229-7yoilsho	3363	14	per	per	IN
cord-006229-7yoilsho	3363	15	cell	cell	NN
cord-006229-7yoilsho	3363	16	for	for	IN
cord-006229-7yoilsho	3363	17	the	the	DT
cord-006229-7yoilsho	3363	18	used	use	VBN
cord-006229-7yoilsho	3363	19	concentration	concentration	NN
cord-006229-7yoilsho	3363	20	range	range	NN
cord-006229-7yoilsho	3363	21	.	.	.
cord-006229-7yoilsho	3364	1	The	the	DT
cord-006229-7yoilsho	3364	2	metal	metal	NN
cord-006229-7yoilsho	3364	3	oxide	oxide	NN
cord-006229-7yoilsho	3364	4	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	3364	5	resulted	result	VBD
cord-006229-7yoilsho	3364	6	in	in	IN
cord-006229-7yoilsho	3364	7	a	a	DT
cord-006229-7yoilsho	3364	8	significant	significant	JJ
cord-006229-7yoilsho	3364	9	reduction	reduction	NN
cord-006229-7yoilsho	3364	10	of	of	IN
cord-006229-7yoilsho	3364	11	cell	cell	NN
cord-006229-7yoilsho	3364	12	viability	viability	NN
cord-006229-7yoilsho	3364	13	with	with	IN
cord-006229-7yoilsho	3364	14	a	a	DT
cord-006229-7yoilsho	3364	15	decrease	decrease	NN
cord-006229-7yoilsho	3364	16	up	up	IN
cord-006229-7yoilsho	3364	17	to	to	TO
cord-006229-7yoilsho	3364	18	40	40	CD
cord-006229-7yoilsho	3364	19	%	%	NN
cord-006229-7yoilsho	3364	20	after	after	IN
cord-006229-7yoilsho	3364	21	copper	copper	NN
cord-006229-7yoilsho	3364	22	oxide	oxide	NN
cord-006229-7yoilsho	3364	23	and	and	CC
cord-006229-7yoilsho	3364	24	zinc	zinc	NN
cord-006229-7yoilsho	3364	25	oxide	oxide	NN
cord-006229-7yoilsho	3364	26	treatment	treatment	NN
cord-006229-7yoilsho	3364	27	.	.	.
cord-006229-7yoilsho	3365	1	For	for	IN
cord-006229-7yoilsho	3365	2	metal	metal	NN
cord-006229-7yoilsho	3365	3	particles	particle	NNS
cord-006229-7yoilsho	3365	4	,	,	,
cord-006229-7yoilsho	3365	5	only	only	RB
cord-006229-7yoilsho	3365	6	for	for	IN
cord-006229-7yoilsho	3365	7	silver	silver	NN
cord-006229-7yoilsho	3365	8	a	a	DT
cord-006229-7yoilsho	3365	9	reduced	reduce	VBN
cord-006229-7yoilsho	3365	10	cell	cell	NN
cord-006229-7yoilsho	3365	11	metabolism	metabolism	NN
cord-006229-7yoilsho	3365	12	of	of	IN
cord-006229-7yoilsho	3365	13	about	about	IN
cord-006229-7yoilsho	3365	14	50	50	CD
cord-006229-7yoilsho	3365	15	%	%	NN
cord-006229-7yoilsho	3365	16	was	be	VBD
cord-006229-7yoilsho	3365	17	detectable	detectable	JJ
cord-006229-7yoilsho	3365	18	by	by	IN
cord-006229-7yoilsho	3365	19	the	the	DT
cord-006229-7yoilsho	3365	20	MTT	MTT	NNP
cord-006229-7yoilsho	3365	21	assay	assay	NN
cord-006229-7yoilsho	3365	22	.	.	.
cord-006229-7yoilsho	3366	1	Low	low	JJ
cord-006229-7yoilsho	3366	2	genotoxic	genotoxic	JJ
cord-006229-7yoilsho	3366	3	effects	effect	NNS
cord-006229-7yoilsho	3366	4	could	could	MD
cord-006229-7yoilsho	3366	5	be	be	VB
cord-006229-7yoilsho	3366	6	determined	determine	VBN
cord-006229-7yoilsho	3366	7	for	for	IN
cord-006229-7yoilsho	3366	8	silver	silver	NN
cord-006229-7yoilsho	3366	9	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	3366	10	(	(	-LRB-
cord-006229-7yoilsho	3366	11	tail	tail	NN
cord-006229-7yoilsho	3366	12	intensity	intensity	NN
cord-006229-7yoilsho	3366	13	about	about	IN
cord-006229-7yoilsho	3366	14	12	12	CD
cord-006229-7yoilsho	3366	15	%	%	NN
cord-006229-7yoilsho	3366	16	;	;	,
cord-006229-7yoilsho	3366	17	control	control	NN
cord-006229-7yoilsho	3366	18	about	about	RB
cord-006229-7yoilsho	3366	19	6	6	CD
cord-006229-7yoilsho	3366	20	%	%	NN
cord-006229-7yoilsho	3366	21	)	)	-RRB-
cord-006229-7yoilsho	3366	22	,	,	,
cord-006229-7yoilsho	3366	23	while	while	IN
cord-006229-7yoilsho	3366	24	for	for	IN
cord-006229-7yoilsho	3366	25	titanium	titanium	NN
cord-006229-7yoilsho	3366	26	dioxide	dioxide	NN
cord-006229-7yoilsho	3366	27	the	the	DT
cord-006229-7yoilsho	3366	28	amount	amount	NN
cord-006229-7yoilsho	3366	29	of	of	IN
cord-006229-7yoilsho	3366	30	oxidized	oxidize	VBN
cord-006229-7yoilsho	3366	31	bases	basis	NNS
cord-006229-7yoilsho	3366	32	was	be	VBD
cord-006229-7yoilsho	3366	33	additionally	additionally	RB
cord-006229-7yoilsho	3366	34	increased	increase	VBN
cord-006229-7yoilsho	3366	35	(	(	-LRB-
cord-006229-7yoilsho	3366	36	tail	tail	NN
cord-006229-7yoilsho	3366	37	intensity	intensity	NN
cord-006229-7yoilsho	3366	38	about	about	IN
cord-006229-7yoilsho	3366	39	20	20	CD
cord-006229-7yoilsho	3366	40	%	%	NN
cord-006229-7yoilsho	3366	41	;	;	,
cord-006229-7yoilsho	3366	42	control	control	NN
cord-006229-7yoilsho	3366	43	about	about	RB
cord-006229-7yoilsho	3366	44	6	6	CD
cord-006229-7yoilsho	3366	45	%	%	NN
cord-006229-7yoilsho	3366	46	)	)	-RRB-
cord-006229-7yoilsho	3366	47	for	for	IN
cord-006229-7yoilsho	3366	48	concentrations	concentration	NNS
cord-006229-7yoilsho	3366	49	above	above	IN
cord-006229-7yoilsho	3366	50	8	8	CD
cord-006229-7yoilsho	3366	51	µg	µg	NN
cord-006229-7yoilsho	3366	52	/	/	SYM
cord-006229-7yoilsho	3366	53	ml	ml	NN
cord-006229-7yoilsho	3366	54	.	.	.
cord-006229-7yoilsho	3367	1	Induction	induction	NN
cord-006229-7yoilsho	3367	2	of	of	IN
cord-006229-7yoilsho	3367	3	apoptosis	apoptosis	NN
cord-006229-7yoilsho	3367	4	was	be	VBD
cord-006229-7yoilsho	3367	5	determined	determine	VBN
cord-006229-7yoilsho	3367	6	for	for	IN
cord-006229-7yoilsho	3367	7	silver	silver	NN
cord-006229-7yoilsho	3367	8	particles	particle	NNS
cord-006229-7yoilsho	3367	9	(	(	-LRB-
cord-006229-7yoilsho	3367	10	up	up	IN
cord-006229-7yoilsho	3367	11	to	to	TO
cord-006229-7yoilsho	3367	12	24	24	CD
cord-006229-7yoilsho	3367	13	%	%	NN
cord-006229-7yoilsho	3367	14	early	early	JJ
cord-006229-7yoilsho	3367	15	apoptotic	apoptotic	JJ
cord-006229-7yoilsho	3367	16	and	and	CC
cord-006229-7yoilsho	3367	17	20	20	CD
cord-006229-7yoilsho	3367	18	%	%	NN
cord-006229-7yoilsho	3367	19	late	late	JJ
cord-006229-7yoilsho	3367	20	apoptotic	apoptotic	JJ
cord-006229-7yoilsho	3367	21	cells	cell	NNS
cord-006229-7yoilsho	3367	22	)	)	-RRB-
cord-006229-7yoilsho	3367	23	as	as	RB
cord-006229-7yoilsho	3367	24	well	well	RB
cord-006229-7yoilsho	3367	25	as	as	IN
cord-006229-7yoilsho	3367	26	for	for	IN
cord-006229-7yoilsho	3367	27	titanium	titanium	NN
cord-006229-7yoilsho	3367	28	dioxide	dioxide	NN
cord-006229-7yoilsho	3367	29	and	and	CC
cord-006229-7yoilsho	3367	30	zinc	zinc	NN
cord-006229-7yoilsho	3367	31	oxide	oxide	NN
cord-006229-7yoilsho	3367	32	(	(	-LRB-
cord-006229-7yoilsho	3367	33	10	10	CD
cord-006229-7yoilsho	3367	34	%	%	NN
cord-006229-7yoilsho	3367	35	each	each	DT
cord-006229-7yoilsho	3367	36	early	early	JJ
cord-006229-7yoilsho	3367	37	apoptotic	apoptotic	JJ
cord-006229-7yoilsho	3367	38	cells	cell	NNS
cord-006229-7yoilsho	3367	39	)	)	-RRB-
cord-006229-7yoilsho	3367	40	,	,	,
cord-006229-7yoilsho	3367	41	whereby	whereby	WRB
cord-006229-7yoilsho	3367	42	the	the	DT
cord-006229-7yoilsho	3367	43	most	most	RBS
cord-006229-7yoilsho	3367	44	significant	significant	JJ
cord-006229-7yoilsho	3367	45	increase	increase	NN
cord-006229-7yoilsho	3367	46	in	in	IN
cord-006229-7yoilsho	3367	47	late	late	JJ
cord-006229-7yoilsho	3367	48	apoptotic	apoptotic	JJ
cord-006229-7yoilsho	3367	49	cells	cell	NNS
cord-006229-7yoilsho	3367	50	was	be	VBD
cord-006229-7yoilsho	3367	51	detected	detect	VBN
cord-006229-7yoilsho	3367	52	for	for	IN
cord-006229-7yoilsho	3367	53	zinc	zinc	NN
cord-006229-7yoilsho	3367	54	oxide	oxide	NN
cord-006229-7yoilsho	3367	55	(	(	-LRB-
cord-006229-7yoilsho	3367	56	up	up	IN
cord-006229-7yoilsho	3367	57	to	to	TO
cord-006229-7yoilsho	3367	58	90	90	CD
cord-006229-7yoilsho	3367	59	%	%	NN
cord-006229-7yoilsho	3367	60	)	)	-RRB-
cord-006229-7yoilsho	3367	61	.	.	.
cord-006229-7yoilsho	3368	1	The	the	DT
cord-006229-7yoilsho	3368	2	results	result	NNS
cord-006229-7yoilsho	3368	3	obtained	obtain	VBN
cord-006229-7yoilsho	3368	4	in	in	IN
cord-006229-7yoilsho	3368	5	our	-PRON-	PRP$
cord-006229-7yoilsho	3368	6	studies	study	NNS
cord-006229-7yoilsho	3368	7	indicate	indicate	VBP
cord-006229-7yoilsho	3368	8	a	a	DT
cord-006229-7yoilsho	3368	9	clear	clear	JJ
cord-006229-7yoilsho	3368	10	particle	particle	NN
cord-006229-7yoilsho	3368	11	-	-	HYPH
cord-006229-7yoilsho	3368	12	dependent	dependent	JJ
cord-006229-7yoilsho	3368	13	influence	influence	NN
cord-006229-7yoilsho	3368	14	on	on	IN
cord-006229-7yoilsho	3368	15	cell	cell	NN
cord-006229-7yoilsho	3368	16	viability	viability	NN
cord-006229-7yoilsho	3368	17	and	and	CC
cord-006229-7yoilsho	3368	18	apoptosis	apoptosis	NN
cord-006229-7yoilsho	3368	19	-	-	HYPH
cord-006229-7yoilsho	3368	20	triggering	trigger	VBG
cord-006229-7yoilsho	3368	21	processes	process	NNS
cord-006229-7yoilsho	3368	22	,	,	,
cord-006229-7yoilsho	3368	23	depending	depend	VBG
cord-006229-7yoilsho	3368	24	on	on	IN
cord-006229-7yoilsho	3368	25	the	the	DT
cord-006229-7yoilsho	3368	26	used	use	VBN
cord-006229-7yoilsho	3368	27	material	material	NN
cord-006229-7yoilsho	3368	28	or	or	CC
cord-006229-7yoilsho	3368	29	the	the	DT
cord-006229-7yoilsho	3368	30	concentration	concentration	NN
cord-006229-7yoilsho	3368	31	deployed	deploy	VBN
cord-006229-7yoilsho	3368	32	,	,	,
cord-006229-7yoilsho	3368	33	while	while	IN
cord-006229-7yoilsho	3368	34	only	only	RB
cord-006229-7yoilsho	3368	35	minor	minor	JJ
cord-006229-7yoilsho	3368	36	changes	change	NNS
cord-006229-7yoilsho	3368	37	of	of	IN
cord-006229-7yoilsho	3368	38	DNA	dna	NN
cord-006229-7yoilsho	3368	39	integrity	integrity	NN
cord-006229-7yoilsho	3368	40	were	be	VBD
cord-006229-7yoilsho	3368	41	detected	detect	VBN
cord-006229-7yoilsho	3368	42	.	.	.
cord-006229-7yoilsho	3369	1	The	the	DT
cord-006229-7yoilsho	3369	2	evolution	evolution	NN
cord-006229-7yoilsho	3369	3	in	in	IN
cord-006229-7yoilsho	3369	4	the	the	DT
cord-006229-7yoilsho	3369	5	field	field	NN
cord-006229-7yoilsho	3369	6	of	of	IN
cord-006229-7yoilsho	3369	7	Nanotechnology	Nanotechnology	NNP
cord-006229-7yoilsho	3369	8	led	lead	VBD
cord-006229-7yoilsho	3369	9	to	to	IN
cord-006229-7yoilsho	3369	10	a	a	DT
cord-006229-7yoilsho	3369	11	variety	variety	NN
cord-006229-7yoilsho	3369	12	of	of	IN
cord-006229-7yoilsho	3369	13	novel	novel	JJ
cord-006229-7yoilsho	3369	14	materials	material	NNS
cord-006229-7yoilsho	3369	15	at	at	IN
cord-006229-7yoilsho	3369	16	the	the	DT
cord-006229-7yoilsho	3369	17	nanoscale	nanoscale	NN
cord-006229-7yoilsho	3369	18	.	.	.
cord-006229-7yoilsho	3370	1	Among	among	IN
cord-006229-7yoilsho	3370	2	them	-PRON-	PRP
cord-006229-7yoilsho	3370	3	are	be	VBP
cord-006229-7yoilsho	3370	4	different	different	JJ
cord-006229-7yoilsho	3370	5	carbon	carbon	NN
cord-006229-7yoilsho	3370	6	materials	material	NNS
cord-006229-7yoilsho	3370	7	like	like	IN
cord-006229-7yoilsho	3370	8	buckyballs	buckyball	NNS
cord-006229-7yoilsho	3370	9	,	,	,
cord-006229-7yoilsho	3370	10	graphene	graphene	NN
cord-006229-7yoilsho	3370	11	nanoplates	nanoplate	NNS
cord-006229-7yoilsho	3370	12	and	and	CC
cord-006229-7yoilsho	3370	13	carbon	carbon	NN
cord-006229-7yoilsho	3370	14	nanotubes	nanotube	NNS
cord-006229-7yoilsho	3370	15	(	(	-LRB-
cord-006229-7yoilsho	3370	16	CNTs	cnt	NNS
cord-006229-7yoilsho	3370	17	)	)	-RRB-
cord-006229-7yoilsho	3370	18	.	.	.
cord-006229-7yoilsho	3371	1	CNTs	cnt	NNS
cord-006229-7yoilsho	3371	2	are	be	VBP
cord-006229-7yoilsho	3371	3	hollow	hollow	JJ
cord-006229-7yoilsho	3371	4	carbon	carbon	NN
cord-006229-7yoilsho	3371	5	fibres	fibre	NNS
cord-006229-7yoilsho	3371	6	with	with	IN
cord-006229-7yoilsho	3371	7	either	either	DT
cord-006229-7yoilsho	3371	8	one	one	NN
cord-006229-7yoilsho	3371	9	(	(	-LRB-
cord-006229-7yoilsho	3371	10	SW	SW	NNP
cord-006229-7yoilsho	3371	11	)	)	-RRB-
cord-006229-7yoilsho	3371	12	or	or	CC
cord-006229-7yoilsho	3371	13	multiple	multiple	JJ
cord-006229-7yoilsho	3371	14	sidewalls	sidewall	NNS
cord-006229-7yoilsho	3371	15	(	(	-LRB-
cord-006229-7yoilsho	3371	16	MW	MW	NNP
cord-006229-7yoilsho	3371	17	)	)	-RRB-
cord-006229-7yoilsho	3371	18	.	.	.
cord-006229-7yoilsho	3372	1	MWCNTs	mwcnt	NNS
cord-006229-7yoilsho	3372	2	usually	usually	RB
cord-006229-7yoilsho	3372	3	show	show	VBP
cord-006229-7yoilsho	3372	4	a	a	DT
cord-006229-7yoilsho	3372	5	diameter	diameter	NN
cord-006229-7yoilsho	3372	6	of	of	IN
cord-006229-7yoilsho	3372	7	up	up	IN
cord-006229-7yoilsho	3372	8	to	to	TO
cord-006229-7yoilsho	3372	9	100	100	CD
cord-006229-7yoilsho	3372	10	nm	nm	NN
cord-006229-7yoilsho	3372	11	and	and	CC
cord-006229-7yoilsho	3372	12	can	can	MD
cord-006229-7yoilsho	3372	13	be	be	VB
cord-006229-7yoilsho	3372	14	several	several	JJ
cord-006229-7yoilsho	3372	15	micrometres	micrometre	NNS
cord-006229-7yoilsho	3372	16	long	long	RB
cord-006229-7yoilsho	3372	17	.	.	.
cord-006229-7yoilsho	3373	1	Because	because	IN
cord-006229-7yoilsho	3373	2	of	of	IN
cord-006229-7yoilsho	3373	3	their	-PRON-	PRP$
cord-006229-7yoilsho	3373	4	nanoscale	nanoscale	NN
cord-006229-7yoilsho	3373	5	diameter	diameter	NN
cord-006229-7yoilsho	3373	6	CNT	cnt	NN
cord-006229-7yoilsho	3373	7	-	-	HYPH
cord-006229-7yoilsho	3373	8	uptake	uptake	NN
cord-006229-7yoilsho	3373	9	can	can	MD
cord-006229-7yoilsho	3373	10	take	take	VB
cord-006229-7yoilsho	3373	11	place	place	NN
cord-006229-7yoilsho	3373	12	directly	directly	RB
cord-006229-7yoilsho	3373	13	through	through	IN
cord-006229-7yoilsho	3373	14	the	the	DT
cord-006229-7yoilsho	3373	15	plasma	plasma	NN
cord-006229-7yoilsho	3373	16	membrane	membrane	NN
cord-006229-7yoilsho	3373	17	of	of	IN
cord-006229-7yoilsho	3373	18	cells	cell	NNS
cord-006229-7yoilsho	3373	19	by	by	IN
cord-006229-7yoilsho	3373	20	the	the	DT
cord-006229-7yoilsho	3373	21	so	so	RB
cord-006229-7yoilsho	3373	22	called	call	VBN
cord-006229-7yoilsho	3373	23	nanoneedle	nanoneedle	JJ
cord-006229-7yoilsho	3373	24	effect	effect	NN
cord-006229-7yoilsho	3373	25	[	[	-LRB-
cord-006229-7yoilsho	3373	26	1	1	CD
cord-006229-7yoilsho	3373	27	]	]	-RRB-
cord-006229-7yoilsho	3373	28	.	.	.
cord-006229-7yoilsho	3374	1	Additionally	additionally	RB
cord-006229-7yoilsho	3374	2	CNTs	cnt	NNS
cord-006229-7yoilsho	3374	3	,	,	,
cord-006229-7yoilsho	3374	4	like	like	IN
cord-006229-7yoilsho	3374	5	most	most	JJS
cord-006229-7yoilsho	3374	6	nanomaterials	nanomaterial	NNS
cord-006229-7yoilsho	3374	7	,	,	,
cord-006229-7yoilsho	3374	8	show	show	VBP
cord-006229-7yoilsho	3374	9	a	a	DT
cord-006229-7yoilsho	3374	10	high	high	JJ
cord-006229-7yoilsho	3374	11	surface	surface	NN
cord-006229-7yoilsho	3374	12	to	to	IN
cord-006229-7yoilsho	3374	13	volume	volume	NN
cord-006229-7yoilsho	3374	14	ratio	ratio	NN
cord-006229-7yoilsho	3374	15	and	and	CC
cord-006229-7yoilsho	3374	16	,	,	,
cord-006229-7yoilsho	3374	17	because	because	IN
cord-006229-7yoilsho	3374	18	of	of	IN
cord-006229-7yoilsho	3374	19	their	-PRON-	PRP$
cord-006229-7yoilsho	3374	20	micro	micro	JJ
cord-006229-7yoilsho	3374	21	scale	scale	NN
cord-006229-7yoilsho	3374	22	length	length	NN
cord-006229-7yoilsho	3374	23	,	,	,
cord-006229-7yoilsho	3374	24	a	a	DT
cord-006229-7yoilsho	3374	25	potentially	potentially	RB
cord-006229-7yoilsho	3374	26	high	high	JJ
cord-006229-7yoilsho	3374	27	loading	loading	NN
cord-006229-7yoilsho	3374	28	capacity	capacity	NN
cord-006229-7yoilsho	3374	29	.	.	.
cord-006229-7yoilsho	3375	1	These	these	DT
cord-006229-7yoilsho	3375	2	properties	property	NNS
cord-006229-7yoilsho	3375	3	make	make	VBP
cord-006229-7yoilsho	3375	4	CNTs	cnt	NNS
cord-006229-7yoilsho	3375	5	interesting	interesting	JJ
cord-006229-7yoilsho	3375	6	for	for	IN
cord-006229-7yoilsho	3375	7	the	the	DT
cord-006229-7yoilsho	3375	8	potential	potential	JJ
cord-006229-7yoilsho	3375	9	use	use	NN
cord-006229-7yoilsho	3375	10	as	as	IN
cord-006229-7yoilsho	3375	11	drug	drug	NN
cord-006229-7yoilsho	3375	12	delivery	delivery	NN
cord-006229-7yoilsho	3375	13	carriers	carrier	NNS
cord-006229-7yoilsho	3375	14	(	(	-LRB-
cord-006229-7yoilsho	3375	15	DDCs	DDCs	NNP
cord-006229-7yoilsho	3375	16	)	)	-RRB-
cord-006229-7yoilsho	3375	17	.	.	.
cord-006229-7yoilsho	3376	1	MWCNTs	MWCNTs	NNP
cord-006229-7yoilsho	3376	2	,	,	,
cord-006229-7yoilsho	3376	3	produced	produce	VBN
cord-006229-7yoilsho	3376	4	via	via	IN
cord-006229-7yoilsho	3376	5	chemical	chemical	JJ
cord-006229-7yoilsho	3376	6	vapour	vapour	NN
cord-006229-7yoilsho	3376	7	deposition	deposition	NN
cord-006229-7yoilsho	3376	8	with	with	IN
cord-006229-7yoilsho	3376	9	a	a	DT
cord-006229-7yoilsho	3376	10	diameter	diameter	NN
cord-006229-7yoilsho	3376	11	of	of	IN
cord-006229-7yoilsho	3376	12	45	45	CD
cord-006229-7yoilsho	3376	13	nm	nm	NN
cord-006229-7yoilsho	3376	14	and	and	CC
cord-006229-7yoilsho	3376	15	16	16	CD
cord-006229-7yoilsho	3376	16	µm	µm	CD
cord-006229-7yoilsho	3376	17	length	length	NN
cord-006229-7yoilsho	3376	18	,	,	,
cord-006229-7yoilsho	3376	19	were	be	VBD
cord-006229-7yoilsho	3376	20	used	use	VBN
cord-006229-7yoilsho	3376	21	in	in	IN
cord-006229-7yoilsho	3376	22	three	three	CD
cord-006229-7yoilsho	3376	23	different	different	JJ
cord-006229-7yoilsho	3376	24	forms	form	NNS
cord-006229-7yoilsho	3376	25	,	,	,
cord-006229-7yoilsho	3376	26	unmodified	unmodified	JJ
cord-006229-7yoilsho	3376	27	,	,	,
cord-006229-7yoilsho	3376	28	acid	acid	NN
cord-006229-7yoilsho	3376	29	oxidized	oxidize	VBN
cord-006229-7yoilsho	3376	30	(	(	-LRB-
cord-006229-7yoilsho	3376	31	Ox_CNT	Ox_CNT	NNP
cord-006229-7yoilsho	3376	32	)	)	-RRB-
cord-006229-7yoilsho	3376	33	and	and	CC
cord-006229-7yoilsho	3376	34	ground	ground	NN
cord-006229-7yoilsho	3376	35	.	.	.
cord-006229-7yoilsho	3377	1	Cytotoxicity	cytotoxicity	NN
cord-006229-7yoilsho	3377	2	testing	testing	NN
cord-006229-7yoilsho	3377	3	was	be	VBD
cord-006229-7yoilsho	3377	4	performed	perform	VBN
cord-006229-7yoilsho	3377	5	in	in	IN
cord-006229-7yoilsho	3377	6	human	human	JJ
cord-006229-7yoilsho	3377	7	umbilical	umbilical	JJ
cord-006229-7yoilsho	3377	8	vein	vein	NN
cord-006229-7yoilsho	3377	9	endothelial	endothelial	JJ
cord-006229-7yoilsho	3377	10	cells	cell	NNS
cord-006229-7yoilsho	3377	11	(	(	-LRB-
cord-006229-7yoilsho	3377	12	HUVEC	HUVEC	NNP
cord-006229-7yoilsho	3377	13	)	)	-RRB-
cord-006229-7yoilsho	3377	14	.	.	.
cord-006229-7yoilsho	3378	1	The	the	DT
cord-006229-7yoilsho	3378	2	cells	cell	NNS
cord-006229-7yoilsho	3378	3	were	be	VBD
cord-006229-7yoilsho	3378	4	seeded	seed	VBN
cord-006229-7yoilsho	3378	5	in	in	IN
cord-006229-7yoilsho	3378	6	48-well	48-well	CD
cord-006229-7yoilsho	3378	7	plates	plate	NNS
cord-006229-7yoilsho	3378	8	and	and	CC
cord-006229-7yoilsho	3378	9	exposed	expose	VBN
cord-006229-7yoilsho	3378	10	to	to	IN
cord-006229-7yoilsho	3378	11	doses	dose	NNS
cord-006229-7yoilsho	3378	12	of	of	IN
cord-006229-7yoilsho	3378	13	1	1	CD
cord-006229-7yoilsho	3378	14	,	,	,
cord-006229-7yoilsho	3378	15	5	5	CD
cord-006229-7yoilsho	3378	16	,	,	,
cord-006229-7yoilsho	3378	17	10	10	CD
cord-006229-7yoilsho	3378	18	and	and	CC
cord-006229-7yoilsho	3378	19	25µg	25µg	NN
cord-006229-7yoilsho	3378	20	/	/	SYM
cord-006229-7yoilsho	3378	21	cm²	cm²	JJ
cord-006229-7yoilsho	3378	22	growth	growth	NN
cord-006229-7yoilsho	3378	23	area	area	NN
cord-006229-7yoilsho	3378	24	of	of	IN
cord-006229-7yoilsho	3378	25	the	the	DT
cord-006229-7yoilsho	3378	26	respective	respective	JJ
cord-006229-7yoilsho	3378	27	CNT	CNT	NNP
cord-006229-7yoilsho	3378	28	type	type	NN
cord-006229-7yoilsho	3378	29	for	for	IN
cord-006229-7yoilsho	3378	30	24h	24h	NNS
cord-006229-7yoilsho	3378	31	.	.	.
cord-006229-7yoilsho	3379	1	The	the	DT
cord-006229-7yoilsho	3379	2	WST-8	WST-8	NNP
cord-006229-7yoilsho	3379	3	assay	assay	NN
cord-006229-7yoilsho	3379	4	was	be	VBD
cord-006229-7yoilsho	3379	5	applied	apply	VBN
cord-006229-7yoilsho	3379	6	for	for	IN
cord-006229-7yoilsho	3379	7	testing	test	VBG
cord-006229-7yoilsho	3379	8	cell	cell	NN
cord-006229-7yoilsho	3379	9	viability	viability	NN
cord-006229-7yoilsho	3379	10	and	and	CC
cord-006229-7yoilsho	3379	11	the	the	DT
cord-006229-7yoilsho	3379	12	LDH	LDH	NNP
cord-006229-7yoilsho	3379	13	cytotoxicity	cytotoxicity	NN
cord-006229-7yoilsho	3379	14	assay	assay	NN
cord-006229-7yoilsho	3379	15	to	to	TO
cord-006229-7yoilsho	3379	16	identify	identify	VB
cord-006229-7yoilsho	3379	17	potential	potential	JJ
cord-006229-7yoilsho	3379	18	damage	damage	NN
cord-006229-7yoilsho	3379	19	to	to	IN
cord-006229-7yoilsho	3379	20	the	the	DT
cord-006229-7yoilsho	3379	21	plasma	plasma	NN
cord-006229-7yoilsho	3379	22	membrane	membrane	NN
cord-006229-7yoilsho	3379	23	and	and	CC
cord-006229-7yoilsho	3379	24	to	to	TO
cord-006229-7yoilsho	3379	25	calculate	calculate	VB
cord-006229-7yoilsho	3379	26	overall	overall	JJ
cord-006229-7yoilsho	3379	27	cytotoxicity	cytotoxicity	NN
cord-006229-7yoilsho	3379	28	.	.	.
cord-006229-7yoilsho	3380	1	The	the	DT
cord-006229-7yoilsho	3380	2	results	result	NNS
cord-006229-7yoilsho	3380	3	show	show	VBP
cord-006229-7yoilsho	3380	4	that	that	IN
cord-006229-7yoilsho	3380	5	an	an	DT
cord-006229-7yoilsho	3380	6	increased	increase	VBN
cord-006229-7yoilsho	3380	7	oxidation	oxidation	NN
cord-006229-7yoilsho	3380	8	time	time	NN
cord-006229-7yoilsho	3380	9	for	for	IN
cord-006229-7yoilsho	3380	10	the	the	DT
cord-006229-7yoilsho	3380	11	Ox_CNTs	Ox_CNTs	NNP
cord-006229-7yoilsho	3380	12	,	,	,
cord-006229-7yoilsho	3380	13	in	in	IN
cord-006229-7yoilsho	3380	14	a	a	DT
cord-006229-7yoilsho	3380	15	H	h	NN
cord-006229-7yoilsho	3380	16	2	2	CD
cord-006229-7yoilsho	3381	1	SO	so	RB
cord-006229-7yoilsho	3381	2	4	4	CD
cord-006229-7yoilsho	3381	3	/HNO	/HNO	.
cord-006229-7yoilsho	3382	1	3	3	CD
cord-006229-7yoilsho	3382	2	mixture	mixture	NN
cord-006229-7yoilsho	3382	3	,	,	,
cord-006229-7yoilsho	3382	4	leads	lead	VBZ
cord-006229-7yoilsho	3382	5	to	to	IN
cord-006229-7yoilsho	3382	6	decreased	decrease	VBN
cord-006229-7yoilsho	3382	7	cytotoxicity	cytotoxicity	NN
cord-006229-7yoilsho	3382	8	in	in	IN
cord-006229-7yoilsho	3382	9	HUVEC	HUVEC	NNP
cord-006229-7yoilsho	3382	10	,	,	,
cord-006229-7yoilsho	3382	11	compared	compare	VBN
cord-006229-7yoilsho	3382	12	to	to	IN
cord-006229-7yoilsho	3382	13	unmodified	unmodified	JJ
cord-006229-7yoilsho	3382	14	MWCNTs	mwcnt	NNS
cord-006229-7yoilsho	3382	15	.	.	.
cord-006229-7yoilsho	3383	1	During	during	IN
cord-006229-7yoilsho	3383	2	the	the	DT
cord-006229-7yoilsho	3383	3	oxidation	oxidation	NN
cord-006229-7yoilsho	3383	4	reactive	reactive	JJ
cord-006229-7yoilsho	3383	5	oxygen	oxygen	NN
cord-006229-7yoilsho	3383	6	groups	group	NNS
cord-006229-7yoilsho	3383	7	are	be	VBP
cord-006229-7yoilsho	3383	8	formed	form	VBN
cord-006229-7yoilsho	3383	9	on	on	IN
cord-006229-7yoilsho	3383	10	the	the	DT
cord-006229-7yoilsho	3383	11	CNT	CNT	NNP
cord-006229-7yoilsho	3383	12	surface	surface	NN
cord-006229-7yoilsho	3383	13	[	[	-LRB-
cord-006229-7yoilsho	3383	14	2	2	CD
cord-006229-7yoilsho	3383	15	]	]	-RRB-
cord-006229-7yoilsho	3383	16	.	.	.
cord-006229-7yoilsho	3384	1	These	these	DT
cord-006229-7yoilsho	3384	2	groups	group	NNS
cord-006229-7yoilsho	3384	3	lead	lead	VBP
cord-006229-7yoilsho	3384	4	to	to	IN
cord-006229-7yoilsho	3384	5	a	a	DT
cord-006229-7yoilsho	3384	6	reduced	reduce	VBN
cord-006229-7yoilsho	3384	7	hydrophobicity	hydrophobicity	NN
cord-006229-7yoilsho	3384	8	of	of	IN
cord-006229-7yoilsho	3384	9	the	the	DT
cord-006229-7yoilsho	3384	10	CNT	CNT	NNP
cord-006229-7yoilsho	3384	11	surface	surface	NN
cord-006229-7yoilsho	3384	12	which	which	WDT
cord-006229-7yoilsho	3384	13	could	could	MD
cord-006229-7yoilsho	3384	14	be	be	VB
cord-006229-7yoilsho	3384	15	responsible	responsible	JJ
cord-006229-7yoilsho	3384	16	for	for	IN
cord-006229-7yoilsho	3384	17	the	the	DT
cord-006229-7yoilsho	3384	18	decline	decline	NN
cord-006229-7yoilsho	3384	19	in	in	IN
cord-006229-7yoilsho	3384	20	cytotoxicity	cytotoxicity	NN
cord-006229-7yoilsho	3384	21	.	.	.
cord-006229-7yoilsho	3385	1	Future	future	JJ
cord-006229-7yoilsho	3385	2	investigations	investigation	NNS
cord-006229-7yoilsho	3385	3	will	will	MD
cord-006229-7yoilsho	3385	4	include	include	VB
cord-006229-7yoilsho	3385	5	the	the	DT
cord-006229-7yoilsho	3385	6	toxicological	toxicological	JJ
cord-006229-7yoilsho	3385	7	analysis	analysis	NN
cord-006229-7yoilsho	3385	8	of	of	IN
cord-006229-7yoilsho	3385	9	MWCNTs	mwcnt	NNS
cord-006229-7yoilsho	3385	10	functionalized	functionalize	VBN
cord-006229-7yoilsho	3385	11	with	with	IN
cord-006229-7yoilsho	3385	12	polyethylene	polyethylene	NN
cord-006229-7yoilsho	3385	13	glycol	glycol	NN
cord-006229-7yoilsho	3385	14	(	(	-LRB-
cord-006229-7yoilsho	3385	15	CNT	CNT	NNP
cord-006229-7yoilsho	3385	16	-	-	HYPH
cord-006229-7yoilsho	3385	17	PEG	PEG	NNP
cord-006229-7yoilsho	3385	18	)	)	-RRB-
cord-006229-7yoilsho	3385	19	.	.	.
cord-006229-7yoilsho	3386	1	The	the	DT
cord-006229-7yoilsho	3386	2	hydrophilic	hydrophilic	JJ
cord-006229-7yoilsho	3386	3	polymer	polymer	NN
cord-006229-7yoilsho	3386	4	PEG	PEG	NNP
cord-006229-7yoilsho	3386	5	will	will	MD
cord-006229-7yoilsho	3386	6	be	be	VB
cord-006229-7yoilsho	3386	7	covalently	covalently	RB
cord-006229-7yoilsho	3386	8	bound	bind	VBN
cord-006229-7yoilsho	3386	9	to	to	IN
cord-006229-7yoilsho	3386	10	the	the	DT
cord-006229-7yoilsho	3386	11	CNT	CNT	NNP
cord-006229-7yoilsho	3386	12	surface	surface	NN
cord-006229-7yoilsho	3386	13	and	and	CC
cord-006229-7yoilsho	3386	14	is	be	VBZ
cord-006229-7yoilsho	3386	15	expected	expect	VBN
cord-006229-7yoilsho	3386	16	to	to	TO
cord-006229-7yoilsho	3386	17	further	further	RB
cord-006229-7yoilsho	3386	18	reduce	reduce	VB
cord-006229-7yoilsho	3386	19	the	the	DT
cord-006229-7yoilsho	3386	20	cytotoxic	cytotoxic	JJ
cord-006229-7yoilsho	3386	21	effect	effect	NN
cord-006229-7yoilsho	3386	22	.	.	.
cord-006229-7yoilsho	3387	1	For	for	IN
cord-006229-7yoilsho	3387	2	these	these	DT
cord-006229-7yoilsho	3387	3	investigations	investigation	NNS
cord-006229-7yoilsho	3387	4	different	different	JJ
cord-006229-7yoilsho	3387	5	analytical	analytical	JJ
cord-006229-7yoilsho	3387	6	methods	method	NNS
cord-006229-7yoilsho	3387	7	will	will	MD
cord-006229-7yoilsho	3387	8	be	be	VB
cord-006229-7yoilsho	3387	9	used	use	VBN
cord-006229-7yoilsho	3387	10	.	.	.
cord-006229-7yoilsho	3388	1	Among	among	IN
cord-006229-7yoilsho	3388	2	others	other	NNS
cord-006229-7yoilsho	3388	3	,	,	,
cord-006229-7yoilsho	3388	4	cell	cell	NN
cord-006229-7yoilsho	3388	5	cycle	cycle	NN
cord-006229-7yoilsho	3388	6	analysis	analysis	NN
cord-006229-7yoilsho	3388	7	,	,	,
cord-006229-7yoilsho	3388	8	the	the	DT
cord-006229-7yoilsho	3388	9	BrdU	BrdU	NNP
cord-006229-7yoilsho	3388	10	assay	assay	NN
cord-006229-7yoilsho	3388	11	,	,	,
cord-006229-7yoilsho	3388	12	pathway	pathway	NN
cord-006229-7yoilsho	3388	13	arrays	array	NNS
cord-006229-7yoilsho	3388	14	and	and	CC
cord-006229-7yoilsho	3388	15	qRT	qRT	NNP
cord-006229-7yoilsho	3388	16	-	-	HYPH
cord-006229-7yoilsho	3388	17	PCR	PCR	NNP
cord-006229-7yoilsho	3388	18	for	for	IN
cord-006229-7yoilsho	3388	19	the	the	DT
cord-006229-7yoilsho	3388	20	investigation	investigation	NN
cord-006229-7yoilsho	3388	21	of	of	IN
cord-006229-7yoilsho	3388	22	gene	gene	NN
cord-006229-7yoilsho	3388	23	expression	expression	NN
cord-006229-7yoilsho	3388	24	and	and	CC
cord-006229-7yoilsho	3388	25	cytokines	cytokine	NNS
cord-006229-7yoilsho	3388	26	will	will	MD
cord-006229-7yoilsho	3388	27	be	be	VB
cord-006229-7yoilsho	3388	28	measured	measure	VBN
cord-006229-7yoilsho	3388	29	.	.	.
cord-006229-7yoilsho	3389	1	These	these	DT
cord-006229-7yoilsho	3389	2	methods	method	NNS
cord-006229-7yoilsho	3389	3	will	will	MD
cord-006229-7yoilsho	3389	4	involve	involve	VB
cord-006229-7yoilsho	3389	5	a	a	DT
cord-006229-7yoilsho	3389	6	co	co	JJ
cord-006229-7yoilsho	3389	7	-	-	JJ
cord-006229-7yoilsho	3389	8	culture	culture	JJ
cord-006229-7yoilsho	3389	9	model	model	NN
cord-006229-7yoilsho	3389	10	of	of	IN
cord-006229-7yoilsho	3389	11	HUVEC	HUVEC	NNP
cord-006229-7yoilsho	3389	12	and	and	CC
cord-006229-7yoilsho	3389	13	human	human	JJ
cord-006229-7yoilsho	3389	14	umbilical	umbilical	JJ
cord-006229-7yoilsho	3389	15	vein	vein	NN
cord-006229-7yoilsho	3389	16	smooth	smooth	JJ
cord-006229-7yoilsho	3389	17	muscle	muscle	NN
cord-006229-7yoilsho	3389	18	cells	cell	NNS
cord-006229-7yoilsho	3389	19	(	(	-LRB-
cord-006229-7yoilsho	3389	20	HUVSMCs	huvsmc	NNS
cord-006229-7yoilsho	3389	21	)	)	-RRB-
cord-006229-7yoilsho	3389	22	for	for	IN
cord-006229-7yoilsho	3389	23	a	a	DT
cord-006229-7yoilsho	3389	24	better	well	JJR
cord-006229-7yoilsho	3389	25	approximation	approximation	NN
cord-006229-7yoilsho	3389	26	to	to	IN
cord-006229-7yoilsho	3389	27	the	the	DT
cord-006229-7yoilsho	3389	28	cellular	cellular	NN
cord-006229-7yoilsho	3389	29	in	in	IN
cord-006229-7yoilsho	3389	30	vivo	vivo	NN
cord-006229-7yoilsho	3389	31	situation	situation	NN
cord-006229-7yoilsho	3389	32	.	.	.
cord-006229-7yoilsho	3390	1	Additionally	additionally	RB
cord-006229-7yoilsho	3390	2	the	the	DT
cord-006229-7yoilsho	3390	3	PEG	PEG	NNP
cord-006229-7yoilsho	3390	4	modified	modify	VBN
cord-006229-7yoilsho	3390	5	MWCNTs	mwcnt	NNS
cord-006229-7yoilsho	3390	6	will	will	MD
cord-006229-7yoilsho	3390	7	be	be	VB
cord-006229-7yoilsho	3390	8	tested	test	VBN
cord-006229-7yoilsho	3390	9	for	for	IN
cord-006229-7yoilsho	3390	10	their	-PRON-	PRP$
cord-006229-7yoilsho	3390	11	loading	loading	NN
cord-006229-7yoilsho	3390	12	capacity	capacity	NN
cord-006229-7yoilsho	3390	13	and	and	CC
cord-006229-7yoilsho	3390	14	efficacy	efficacy	NN
cord-006229-7yoilsho	3390	15	with	with	IN
cord-006229-7yoilsho	3390	16	the	the	DT
cord-006229-7yoilsho	3390	17	anticancer	anticancer	JJ
cord-006229-7yoilsho	3390	18	drug	drug	NN
cord-006229-7yoilsho	3390	19	Doxorubicin	Doxorubicin	NNP
cord-006229-7yoilsho	3390	20	for	for	IN
cord-006229-7yoilsho	3390	21	a	a	DT
cord-006229-7yoilsho	3390	22	potential	potential	JJ
cord-006229-7yoilsho	3390	23	use	use	NN
cord-006229-7yoilsho	3390	24	as	as	IN
cord-006229-7yoilsho	3390	25	an	an	DT
cord-006229-7yoilsho	3390	26	intravenous	intravenous	JJ
cord-006229-7yoilsho	3390	27	drug	drug	NN
cord-006229-7yoilsho	3390	28	delivery	delivery	NN
cord-006229-7yoilsho	3390	29	carrier	carrier	NN
cord-006229-7yoilsho	3390	30	in	in	IN
cord-006229-7yoilsho	3390	31	vivo	vivo	NNP
cord-006229-7yoilsho	3390	32	.	.	.
cord-006229-7yoilsho	3391	1	Although	although	IN
cord-006229-7yoilsho	3391	2	Aluminium	Aluminium	NNP
cord-006229-7yoilsho	3391	3	is	be	VBZ
cord-006229-7yoilsho	3391	4	one	one	CD
cord-006229-7yoilsho	3391	5	of	of	IN
cord-006229-7yoilsho	3391	6	the	the	DT
cord-006229-7yoilsho	3391	7	most	most	RBS
cord-006229-7yoilsho	3391	8	common	common	JJ
cord-006229-7yoilsho	3391	9	elements	element	NNS
cord-006229-7yoilsho	3391	10	in	in	IN
cord-006229-7yoilsho	3391	11	the	the	DT
cord-006229-7yoilsho	3391	12	biosphere	biosphere	NN
cord-006229-7yoilsho	3391	13	,	,	,
cord-006229-7yoilsho	3391	14	up	up	IN
cord-006229-7yoilsho	3391	15	to	to	IN
cord-006229-7yoilsho	3391	16	now	now	RB
cord-006229-7yoilsho	3391	17	little	little	JJ
cord-006229-7yoilsho	3391	18	is	be	VBZ
cord-006229-7yoilsho	3391	19	known	know	VBN
cord-006229-7yoilsho	3391	20	about	about	IN
cord-006229-7yoilsho	3391	21	its	-PRON-	PRP$
cord-006229-7yoilsho	3391	22	impact	impact	NN
cord-006229-7yoilsho	3391	23	on	on	IN
cord-006229-7yoilsho	3391	24	human	human	JJ
cord-006229-7yoilsho	3391	25	health	health	NN
cord-006229-7yoilsho	3391	26	.	.	.
cord-006229-7yoilsho	3392	1	Aluminium	aluminium	NN
cord-006229-7yoilsho	3392	2	and	and	CC
cord-006229-7yoilsho	3392	3	its	-PRON-	PRP$
cord-006229-7yoilsho	3392	4	chemical	chemical	NN
cord-006229-7yoilsho	3392	5	derivatives	derivative	NNS
cord-006229-7yoilsho	3392	6	are	be	VBP
cord-006229-7yoilsho	3392	7	highly	highly	RB
cord-006229-7yoilsho	3392	8	abundant	abundant	JJ
cord-006229-7yoilsho	3392	9	in	in	IN
cord-006229-7yoilsho	3392	10	food	food	NN
cord-006229-7yoilsho	3392	11	,	,	,
cord-006229-7yoilsho	3392	12	food	food	NN
cord-006229-7yoilsho	3392	13	contact	contact	NN
cord-006229-7yoilsho	3392	14	materials	material	NNS
cord-006229-7yoilsho	3392	15	and	and	CC
cord-006229-7yoilsho	3392	16	consumer	consumer	NN
cord-006229-7yoilsho	3392	17	products	product	NNS
cord-006229-7yoilsho	3392	18	what	what	WP
cord-006229-7yoilsho	3392	19	leads	lead	VBZ
cord-006229-7yoilsho	3392	20	to	to	IN
cord-006229-7yoilsho	3392	21	an	an	DT
cord-006229-7yoilsho	3392	22	exposition	exposition	NN
cord-006229-7yoilsho	3392	23	via	via	IN
cord-006229-7yoilsho	3392	24	the	the	DT
cord-006229-7yoilsho	3392	25	gastrointestinal	gastrointestinal	JJ
cord-006229-7yoilsho	3392	26	tract	tract	NN
cord-006229-7yoilsho	3392	27	(	(	-LRB-
cord-006229-7yoilsho	3392	28	GI	GI	NNP
cord-006229-7yoilsho	3392	29	tract	tract	NN
cord-006229-7yoilsho	3392	30	)	)	-RRB-
cord-006229-7yoilsho	3392	31	,	,	,
cord-006229-7yoilsho	3392	32	the	the	DT
cord-006229-7yoilsho	3392	33	lung	lung	NN
cord-006229-7yoilsho	3392	34	and	and	CC
cord-006229-7yoilsho	3392	35	via	via	IN
cord-006229-7yoilsho	3392	36	skin	skin	NN
cord-006229-7yoilsho	3392	37	contact	contact	NN
cord-006229-7yoilsho	3392	38	.	.	.
cord-006229-7yoilsho	3393	1	Recently	recently	RB
cord-006229-7yoilsho	3393	2	,	,	,
cord-006229-7yoilsho	3393	3	Aluminium	Aluminium	NNP
cord-006229-7yoilsho	3393	4	is	be	VBZ
cord-006229-7yoilsho	3393	5	hypothized	hypothize	VBN
cord-006229-7yoilsho	3393	6	to	to	TO
cord-006229-7yoilsho	3393	7	cohere	cohere	VB
cord-006229-7yoilsho	3393	8	with	with	IN
cord-006229-7yoilsho	3393	9	cancer	cancer	NN
cord-006229-7yoilsho	3393	10	and	and	CC
cord-006229-7yoilsho	3393	11	neurodegenerative	neurodegenerative	JJ
cord-006229-7yoilsho	3393	12	disorders	disorder	NNS
cord-006229-7yoilsho	3393	13	.	.	.
cord-006229-7yoilsho	3394	1	Lately	lately	RB
cord-006229-7yoilsho	3394	2	,	,	,
cord-006229-7yoilsho	3394	3	due	due	IN
cord-006229-7yoilsho	3394	4	to	to	IN
cord-006229-7yoilsho	3394	5	an	an	DT
cord-006229-7yoilsho	3394	6	increasing	increase	VBG
cord-006229-7yoilsho	3394	7	attentiveness	attentiveness	NN
cord-006229-7yoilsho	3394	8	on	on	IN
cord-006229-7yoilsho	3394	9	this	this	DT
cord-006229-7yoilsho	3394	10	topic	topic	NN
cord-006229-7yoilsho	3394	11	,	,	,
cord-006229-7yoilsho	3394	12	limiting	limit	VBG
cord-006229-7yoilsho	3394	13	values	value	NNS
cord-006229-7yoilsho	3394	14	for	for	IN
cord-006229-7yoilsho	3394	15	food	food	NN
cord-006229-7yoilsho	3394	16	additives	additive	NNS
cord-006229-7yoilsho	3394	17	have	have	VBP
cord-006229-7yoilsho	3394	18	been	be	VBN
cord-006229-7yoilsho	3394	19	tightened	tighten	VBN
cord-006229-7yoilsho	3394	20	by	by	IN
cord-006229-7yoilsho	3394	21	the	the	DT
cord-006229-7yoilsho	3394	22	EU	EU	NNP
cord-006229-7yoilsho	3394	23	commission	commission	NN
cord-006229-7yoilsho	3394	24	.	.	.
cord-006229-7yoilsho	3395	1	However	however	RB
cord-006229-7yoilsho	3395	2	,	,	,
cord-006229-7yoilsho	3395	3	cellular	cellular	JJ
cord-006229-7yoilsho	3395	4	effects	effect	NNS
cord-006229-7yoilsho	3395	5	of	of	IN
cord-006229-7yoilsho	3395	6	Aluminium	aluminium	NN
cord-006229-7yoilsho	3395	7	and	and	CC
cord-006229-7yoilsho	3395	8	especially	especially	RB
cord-006229-7yoilsho	3395	9	Aluminium	aluminium	NN
cord-006229-7yoilsho	3395	10	-	-	HYPH
cord-006229-7yoilsho	3395	11	containing	contain	VBG
cord-006229-7yoilsho	3395	12	nanomaterials	nanomaterial	NNS
cord-006229-7yoilsho	3395	13	,	,	,
cord-006229-7yoilsho	3395	14	are	be	VBP
cord-006229-7yoilsho	3395	15	in	in	IN
cord-006229-7yoilsho	3395	16	the	the	DT
cord-006229-7yoilsho	3395	17	focus	focus	NN
cord-006229-7yoilsho	3395	18	of	of	IN
cord-006229-7yoilsho	3395	19	our	-PRON-	PRP$
cord-006229-7yoilsho	3395	20	research	research	NN
cord-006229-7yoilsho	3395	21	activities	activity	NNS
cord-006229-7yoilsho	3395	22	,	,	,
cord-006229-7yoilsho	3395	23	for	for	IN
cord-006229-7yoilsho	3395	24	example	example	NN
cord-006229-7yoilsho	3395	25	in	in	IN
cord-006229-7yoilsho	3395	26	the	the	DT
cord-006229-7yoilsho	3395	27	international	international	JJ
cord-006229-7yoilsho	3395	28	SolNanoTOX	SolNanoTOX	NNP
cord-006229-7yoilsho	3395	29	project	project	NN
cord-006229-7yoilsho	3395	30	.	.	.
cord-006229-7yoilsho	3396	1	We	-PRON-	PRP
cord-006229-7yoilsho	3396	2	established	establish	VBD
cord-006229-7yoilsho	3396	3	an	an	DT
cord-006229-7yoilsho	3396	4	in	in	FW
cord-006229-7yoilsho	3396	5	vitro	vitro	FW
cord-006229-7yoilsho	3396	6	simulation	simulation	NN
cord-006229-7yoilsho	3396	7	system	system	NN
cord-006229-7yoilsho	3396	8	of	of	IN
cord-006229-7yoilsho	3396	9	the	the	DT
cord-006229-7yoilsho	3396	10	GI	GI	NNP
cord-006229-7yoilsho	3396	11	tract	tract	NN
cord-006229-7yoilsho	3396	12	,	,	,
cord-006229-7yoilsho	3396	13	where	where	WRB
cord-006229-7yoilsho	3396	14	nanomaterials	nanomaterial	NNS
cord-006229-7yoilsho	3396	15	undergo	undergo	VBP
cord-006229-7yoilsho	3396	16	the	the	DT
cord-006229-7yoilsho	3396	17	different	different	JJ
cord-006229-7yoilsho	3396	18	physiological	physiological	JJ
cord-006229-7yoilsho	3396	19	,	,	,
cord-006229-7yoilsho	3396	20	chemical	chemical	JJ
cord-006229-7yoilsho	3396	21	and	and	CC
cord-006229-7yoilsho	3396	22	proteinbiochemical	proteinbiochemical	JJ
cord-006229-7yoilsho	3396	23	conditions	condition	NNS
cord-006229-7yoilsho	3396	24	of	of	IN
cord-006229-7yoilsho	3396	25	saliva	saliva	NN
cord-006229-7yoilsho	3396	26	,	,	,
cord-006229-7yoilsho	3396	27	gastric	gastric	JJ
cord-006229-7yoilsho	3396	28	juice	juice	NN
cord-006229-7yoilsho	3396	29	and	and	CC
cord-006229-7yoilsho	3396	30	the	the	DT
cord-006229-7yoilsho	3396	31	intestine	intestine	NN
cord-006229-7yoilsho	3396	32	.	.	.
cord-006229-7yoilsho	3397	1	The	the	DT
cord-006229-7yoilsho	3397	2	artificially	artificially	RB
cord-006229-7yoilsho	3397	3	digested	digest	VBN
cord-006229-7yoilsho	3397	4	nanomaterials	nanomaterial	NNS
cord-006229-7yoilsho	3397	5	,	,	,
cord-006229-7yoilsho	3397	6	as	as	RB
cord-006229-7yoilsho	3397	7	well	well	RB
cord-006229-7yoilsho	3397	8	as	as	IN
cord-006229-7yoilsho	3397	9	soluble	soluble	JJ
cord-006229-7yoilsho	3397	10	Aluminiumchloride	Aluminiumchloride	NNP
cord-006229-7yoilsho	3397	11	as	as	IN
cord-006229-7yoilsho	3397	12	ionic	ionic	JJ
cord-006229-7yoilsho	3397	13	control	control	NN
cord-006229-7yoilsho	3397	14	substance	substance	NN
cord-006229-7yoilsho	3397	15	,	,	,
cord-006229-7yoilsho	3397	16	were	be	VBD
cord-006229-7yoilsho	3397	17	subjected	subject	VBN
cord-006229-7yoilsho	3397	18	to	to	IN
cord-006229-7yoilsho	3397	19	several	several	JJ
cord-006229-7yoilsho	3397	20	analytical	analytical	JJ
cord-006229-7yoilsho	3397	21	and	and	CC
cord-006229-7yoilsho	3397	22	biochemical	biochemical	JJ
cord-006229-7yoilsho	3397	23	methods	method	NNS
cord-006229-7yoilsho	3397	24	to	to	TO
cord-006229-7yoilsho	3397	25	characterize	characterize	VB
cord-006229-7yoilsho	3397	26	their	-PRON-	PRP$
cord-006229-7yoilsho	3397	27	change	change	NN
cord-006229-7yoilsho	3397	28	of	of	IN
cord-006229-7yoilsho	3397	29	appearance	appearance	NN
cord-006229-7yoilsho	3397	30	and	and	CC
cord-006229-7yoilsho	3397	31	their	-PRON-	PRP$
cord-006229-7yoilsho	3397	32	cytotoxic	cytotoxic	JJ
cord-006229-7yoilsho	3397	33	effects	effect	NNS
cord-006229-7yoilsho	3397	34	on	on	IN
cord-006229-7yoilsho	3397	35	intestinal	intestinal	JJ
cord-006229-7yoilsho	3397	36	cellular	cellular	JJ
cord-006229-7yoilsho	3397	37	models	model	NNS
cord-006229-7yoilsho	3397	38	.	.	.
cord-006229-7yoilsho	3398	1	We	-PRON-	PRP
cord-006229-7yoilsho	3398	2	observed	observe	VBD
cord-006229-7yoilsho	3398	3	the	the	DT
cord-006229-7yoilsho	3398	4	fate	fate	NN
cord-006229-7yoilsho	3398	5	of	of	IN
cord-006229-7yoilsho	3398	6	the	the	DT
cord-006229-7yoilsho	3398	7	nanomaterials	nanomaterial	NNS
cord-006229-7yoilsho	3398	8	during	during	IN
cord-006229-7yoilsho	3398	9	typical	typical	JJ
cord-006229-7yoilsho	3398	10	pH	ph	NN
cord-006229-7yoilsho	3398	11	-	-	HYPH
cord-006229-7yoilsho	3398	12	values	value	NNS
cord-006229-7yoilsho	3398	13	of	of	IN
cord-006229-7yoilsho	3398	14	saliva	saliva	NN
cord-006229-7yoilsho	3398	15	,	,	,
cord-006229-7yoilsho	3398	16	gastric	gastric	JJ
cord-006229-7yoilsho	3398	17	and	and	CC
cord-006229-7yoilsho	3398	18	intestinal	intestinal	JJ
cord-006229-7yoilsho	3398	19	juice	juice	NN
cord-006229-7yoilsho	3398	20	with	with	IN
cord-006229-7yoilsho	3398	21	Dynamic	dynamic	JJ
cord-006229-7yoilsho	3398	22	light	light	JJ
cord-006229-7yoilsho	3398	23	scattering	scattering	NN
cord-006229-7yoilsho	3398	24	measurements	measurement	NNS
cord-006229-7yoilsho	3398	25	and	and	CC
cord-006229-7yoilsho	3398	26	ICP	ICP	NNP
cord-006229-7yoilsho	3398	27	-	-	HYPH
cord-006229-7yoilsho	3398	28	MS	MS	NNP
cord-006229-7yoilsho	3398	29	in	in	IN
cord-006229-7yoilsho	3398	30	the	the	DT
cord-006229-7yoilsho	3398	31	single	single	JJ
cord-006229-7yoilsho	3398	32	particle	particle	NN
cord-006229-7yoilsho	3398	33	mode	mode	NN
cord-006229-7yoilsho	3398	34	.	.	.
cord-006229-7yoilsho	3399	1	After	after	IN
cord-006229-7yoilsho	3399	2	observable	observable	JJ
cord-006229-7yoilsho	3399	3	disappearance	disappearance	NN
cord-006229-7yoilsho	3399	4	at	at	IN
cord-006229-7yoilsho	3399	5	pH	ph	NN
cord-006229-7yoilsho	3399	6	2	2	CD
cord-006229-7yoilsho	3400	1	the	the	DT
cord-006229-7yoilsho	3400	2	particles	particle	NNS
cord-006229-7yoilsho	3400	3	recovered	recover	VBN
cord-006229-7yoilsho	3400	4	in	in	IN
cord-006229-7yoilsho	3400	5	the	the	DT
cord-006229-7yoilsho	3400	6	simulated	simulated	JJ
cord-006229-7yoilsho	3400	7	intestinal	intestinal	JJ
cord-006229-7yoilsho	3400	8	fluid	fluid	NN
cord-006229-7yoilsho	3400	9	.	.	.
cord-006229-7yoilsho	3401	1	The	the	DT
cord-006229-7yoilsho	3401	2	simulation	simulation	NN
cord-006229-7yoilsho	3401	3	of	of	IN
cord-006229-7yoilsho	3401	4	the	the	DT
cord-006229-7yoilsho	3401	5	GI	GI	NNP
cord-006229-7yoilsho	3401	6	tract	tract	NN
cord-006229-7yoilsho	3401	7	,	,	,
cord-006229-7yoilsho	3401	8	mainly	mainly	RB
cord-006229-7yoilsho	3401	9	the	the	DT
cord-006229-7yoilsho	3401	10	change	change	NN
cord-006229-7yoilsho	3401	11	of	of	IN
cord-006229-7yoilsho	3401	12	pH	pH	NNP
cord-006229-7yoilsho	3401	13	settings	setting	NNS
cord-006229-7yoilsho	3401	14	,	,	,
cord-006229-7yoilsho	3401	15	may	may	MD
cord-006229-7yoilsho	3401	16	lead	lead	VB
cord-006229-7yoilsho	3401	17	to	to	IN
cord-006229-7yoilsho	3401	18	a	a	DT
cord-006229-7yoilsho	3401	19	certain	certain	JJ
cord-006229-7yoilsho	3401	20	chemical	chemical	NN
cord-006229-7yoilsho	3401	21	activation	activation	NN
cord-006229-7yoilsho	3401	22	of	of	IN
cord-006229-7yoilsho	3401	23	Aluminium	Aluminium	NNP
cord-006229-7yoilsho	3401	24	that	that	WDT
cord-006229-7yoilsho	3401	25	can	can	MD
cord-006229-7yoilsho	3401	26	increase	increase	VB
cord-006229-7yoilsho	3401	27	bioavailability	bioavailability	NN
cord-006229-7yoilsho	3401	28	in	in	IN
cord-006229-7yoilsho	3401	29	the	the	DT
cord-006229-7yoilsho	3401	30	intestine	intestine	NN
cord-006229-7yoilsho	3401	31	after	after	IN
cord-006229-7yoilsho	3401	32	oral	oral	JJ
cord-006229-7yoilsho	3401	33	uptake	uptake	NN
cord-006229-7yoilsho	3401	34	of	of	IN
cord-006229-7yoilsho	3401	35	Aluminium	aluminium	NN
cord-006229-7yoilsho	3401	36	-	-	HYPH
cord-006229-7yoilsho	3401	37	containing	contain	VBG
cord-006229-7yoilsho	3401	38	food	food	NN
cord-006229-7yoilsho	3401	39	products	product	NNS
cord-006229-7yoilsho	3401	40	.	.	.
cord-006229-7yoilsho	3402	1	In	in	IN
cord-006229-7yoilsho	3402	2	vitro	vitro	FW
cord-006229-7yoilsho	3402	3	assays	assay	NNS
cord-006229-7yoilsho	3402	4	like	like	IN
cord-006229-7yoilsho	3402	5	CTB	CTB	NNP
cord-006229-7yoilsho	3402	6	,	,	,
cord-006229-7yoilsho	3402	7	MTT	MTT	NNP
cord-006229-7yoilsho	3402	8	and	and	CC
cord-006229-7yoilsho	3402	9	cellular	cellular	JJ
cord-006229-7yoilsho	3402	10	impedance	impedance	NN
cord-006229-7yoilsho	3402	11	measurements	measurement	NNS
cord-006229-7yoilsho	3402	12	showed	show	VBD
cord-006229-7yoilsho	3402	13	that	that	IN
cord-006229-7yoilsho	3402	14	there	there	EX
cord-006229-7yoilsho	3402	15	were	be	VBD
cord-006229-7yoilsho	3402	16	no	no	DT
cord-006229-7yoilsho	3402	17	acute	acute	JJ
cord-006229-7yoilsho	3402	18	cytotoxic	cytotoxic	JJ
cord-006229-7yoilsho	3402	19	effects	effect	NNS
cord-006229-7yoilsho	3402	20	measurable	measurable	JJ
cord-006229-7yoilsho	3402	21	after	after	IN
cord-006229-7yoilsho	3402	22	a	a	DT
cord-006229-7yoilsho	3402	23	period	period	NN
cord-006229-7yoilsho	3402	24	up	up	IN
cord-006229-7yoilsho	3402	25	to	to	IN
cord-006229-7yoilsho	3402	26	48h	48h	NNS
cord-006229-7yoilsho	3402	27	after	after	IN
cord-006229-7yoilsho	3402	28	incubation	incubation	NN
cord-006229-7yoilsho	3402	29	,	,	,
cord-006229-7yoilsho	3402	30	comparable	comparable	JJ
cord-006229-7yoilsho	3402	31	to	to	IN
cord-006229-7yoilsho	3402	32	undigested	undigested	JJ
cord-006229-7yoilsho	3402	33	particles	particle	NNS
cord-006229-7yoilsho	3402	34	.	.	.
cord-006229-7yoilsho	3403	1	In	in	IN
cord-006229-7yoilsho	3403	2	contrast	contrast	NN
cord-006229-7yoilsho	3403	3	,	,	,
cord-006229-7yoilsho	3403	4	high	high	JJ
cord-006229-7yoilsho	3403	5	amounts	amount	NNS
cord-006229-7yoilsho	3403	6	of	of	IN
cord-006229-7yoilsho	3403	7	Aluminium	aluminium	NN
cord-006229-7yoilsho	3403	8	ions	ion	NNS
cord-006229-7yoilsho	3403	9	showed	show	VBD
cord-006229-7yoilsho	3403	10	additional	additional	JJ
cord-006229-7yoilsho	3403	11	effects	effect	NNS
cord-006229-7yoilsho	3403	12	on	on	IN
cord-006229-7yoilsho	3403	13	cell	cell	NN
cord-006229-7yoilsho	3403	14	viability	viability	NN
cord-006229-7yoilsho	3403	15	compared	compare	VBN
cord-006229-7yoilsho	3403	16	to	to	IN
cord-006229-7yoilsho	3403	17	non	non	JJ
cord-006229-7yoilsho	3403	18	-	-	JJ
cord-006229-7yoilsho	3403	19	digested	digested	JJ
cord-006229-7yoilsho	3403	20	Aluminium	aluminium	NN
cord-006229-7yoilsho	3403	21	ions	ion	NNS
cord-006229-7yoilsho	3403	22	.	.	.
cord-006229-7yoilsho	3404	1	Although	although	IN
cord-006229-7yoilsho	3404	2	toxicological	toxicological	JJ
cord-006229-7yoilsho	3404	3	potential	potential	NN
cord-006229-7yoilsho	3404	4	of	of	IN
cord-006229-7yoilsho	3404	5	Al	Al	NNP
cord-006229-7yoilsho	3404	6	ions	ion	NNS
cord-006229-7yoilsho	3404	7	to	to	IN
cord-006229-7yoilsho	3404	8	healthy	healthy	JJ
cord-006229-7yoilsho	3404	9	tissue	tissue	NN
cord-006229-7yoilsho	3404	10	appears	appear	VBZ
cord-006229-7yoilsho	3404	11	to	to	TO
cord-006229-7yoilsho	3404	12	be	be	VB
cord-006229-7yoilsho	3404	13	low	low	JJ
cord-006229-7yoilsho	3404	14	,	,	,
cord-006229-7yoilsho	3404	15	increased	increase	VBN
cord-006229-7yoilsho	3404	16	hazardous	hazardous	JJ
cord-006229-7yoilsho	3404	17	potential	potential	NN
cord-006229-7yoilsho	3404	18	can	can	MD
cord-006229-7yoilsho	3404	19	not	not	RB
cord-006229-7yoilsho	3404	20	be	be	VB
cord-006229-7yoilsho	3404	21	ruled	rule	VBN
cord-006229-7yoilsho	3404	22	out	out	RP
cord-006229-7yoilsho	3404	23	to	to	TO
cord-006229-7yoilsho	3404	24	pre	pre	VB
cord-006229-7yoilsho	3404	25	-	-	JJ
cord-006229-7yoilsho	3404	26	damaged	damaged	JJ
cord-006229-7yoilsho	3404	27	tissue	tissue	NN
cord-006229-7yoilsho	3404	28	and	and	CC
cord-006229-7yoilsho	3404	29	can	can	MD
cord-006229-7yoilsho	3404	30	have	have	VB
cord-006229-7yoilsho	3404	31	a	a	DT
cord-006229-7yoilsho	3404	32	relevance	relevance	NN
cord-006229-7yoilsho	3404	33	for	for	IN
cord-006229-7yoilsho	3404	34	special	special	JJ
cord-006229-7yoilsho	3404	35	consumer	consumer	NN
cord-006229-7yoilsho	3404	36	groups	group	NNS
cord-006229-7yoilsho	3404	37	with	with	IN
cord-006229-7yoilsho	3404	38	for	for	IN
cord-006229-7yoilsho	3404	39	example	example	NN
cord-006229-7yoilsho	3404	40	chronical	chronical	JJ
cord-006229-7yoilsho	3404	41	intestinal	intestinal	JJ
cord-006229-7yoilsho	3404	42	inflammation	inflammation	NN
cord-006229-7yoilsho	3404	43	or	or	CC
cord-006229-7yoilsho	3404	44	dietary	dietary	JJ
cord-006229-7yoilsho	3404	45	eating	eat	VBG
cord-006229-7yoilsho	3404	46	behavior	behavior	NN
cord-006229-7yoilsho	3404	47	combined	combine	VBN
cord-006229-7yoilsho	3404	48	with	with	IN
cord-006229-7yoilsho	3404	49	high	high	JJ
cord-006229-7yoilsho	3404	50	exposure	exposure	NN
cord-006229-7yoilsho	3404	51	to	to	IN
cord-006229-7yoilsho	3404	52	Al	Al	NNP
cord-006229-7yoilsho	3404	53	-	-	HYPH
cord-006229-7yoilsho	3404	54	containing	contain	VBG
cord-006229-7yoilsho	3404	55	food	food	NN
cord-006229-7yoilsho	3404	56	products	product	NNS
cord-006229-7yoilsho	3404	57	.	.	.
cord-006229-7yoilsho	3405	1	In	in	IN
cord-006229-7yoilsho	3405	2	the	the	DT
cord-006229-7yoilsho	3405	3	EU	EU	NNP
cord-006229-7yoilsho	3405	4	,	,	,
cord-006229-7yoilsho	3405	5	there	there	EX
cord-006229-7yoilsho	3405	6	is	be	VBZ
cord-006229-7yoilsho	3405	7	a	a	DT
cord-006229-7yoilsho	3405	8	strong	strong	JJ
cord-006229-7yoilsho	3405	9	need	need	NN
cord-006229-7yoilsho	3405	10	for	for	IN
cord-006229-7yoilsho	3405	11	solutions	solution	NNS
cord-006229-7yoilsho	3405	12	to	to	TO
cord-006229-7yoilsho	3405	13	substitute	substitute	VB
cord-006229-7yoilsho	3405	14	halogenated	halogenated	JJ
cord-006229-7yoilsho	3405	15	flame	flame	NN
cord-006229-7yoilsho	3405	16	retardant	retardant	NN
cord-006229-7yoilsho	3405	17	(	(	-LRB-
cord-006229-7yoilsho	3405	18	HFR	HFR	NNP
cord-006229-7yoilsho	3405	19	)	)	-RRB-
cord-006229-7yoilsho	3405	20	additives	additive	NNS
cord-006229-7yoilsho	3405	21	,	,	,
cord-006229-7yoilsho	3405	22	employed	employ	VBN
cord-006229-7yoilsho	3405	23	in	in	IN
cord-006229-7yoilsho	3405	24	the	the	DT
cord-006229-7yoilsho	3405	25	fabrication	fabrication	NN
cord-006229-7yoilsho	3405	26	of	of	IN
cord-006229-7yoilsho	3405	27	FR	fr	NN
cord-006229-7yoilsho	3405	28	thermoplastic	thermoplastic	NNP
cord-006229-7yoilsho	3405	29	and	and	CC
cord-006229-7yoilsho	3405	30	thermoset	thermoset	NN
cord-006229-7yoilsho	3405	31	materials	material	NNS
cord-006229-7yoilsho	3405	32	.	.	.
cord-006229-7yoilsho	3406	1	These	these	DT
cord-006229-7yoilsho	3406	2	materials	material	NNS
cord-006229-7yoilsho	3406	3	are	be	VBP
cord-006229-7yoilsho	3406	4	used	use	VBN
cord-006229-7yoilsho	3406	5	in	in	IN
cord-006229-7yoilsho	3406	6	diverse	diverse	JJ
cord-006229-7yoilsho	3406	7	commercial	commercial	JJ
cord-006229-7yoilsho	3406	8	products	product	NNS
cord-006229-7yoilsho	3406	9	,	,	,
cord-006229-7yoilsho	3406	10	applications	application	NNS
cord-006229-7yoilsho	3406	11	and	and	CC
cord-006229-7yoilsho	3406	12	markets	market	NNS
cord-006229-7yoilsho	3406	13	,	,	,
cord-006229-7yoilsho	3406	14	such	such	JJ
cord-006229-7yoilsho	3406	15	as	as	IN
cord-006229-7yoilsho	3406	16	electrical	electrical	JJ
cord-006229-7yoilsho	3406	17	/	/	SYM
cord-006229-7yoilsho	3406	18	electronic	electronic	JJ
cord-006229-7yoilsho	3406	19	devices	device	NNS
cord-006229-7yoilsho	3406	20	,	,	,
cord-006229-7yoilsho	3406	21	low	low	JJ
cord-006229-7yoilsho	3406	22	-	-	HYPH
cord-006229-7yoilsho	3406	23	voltage	voltage	NN
cord-006229-7yoilsho	3406	24	wires	wire	NNS
cord-006229-7yoilsho	3406	25	or	or	CC
cord-006229-7yoilsho	3406	26	household	household	NN
cord-006229-7yoilsho	3406	27	appliances	appliance	NNS
cord-006229-7yoilsho	3406	28	.	.	.
cord-006229-7yoilsho	3407	1	The	the	DT
cord-006229-7yoilsho	3407	2	PHOENIX	PHOENIX	NNP
cord-006229-7yoilsho	3407	3	project	project	NN
cord-006229-7yoilsho	3407	4	,	,	,
cord-006229-7yoilsho	3407	5	funded	fund	VBN
cord-006229-7yoilsho	3407	6	by	by	IN
cord-006229-7yoilsho	3407	7	the	the	DT
cord-006229-7yoilsho	3407	8	European	European	NNP
cord-006229-7yoilsho	3407	9	Union	Union	NNP
cord-006229-7yoilsho	3407	10	7	7	CD
cord-006229-7yoilsho	3407	11	th	th	NNP
cord-006229-7yoilsho	3407	12	Framework	Framework	NNP
cord-006229-7yoilsho	3407	13	Program	Program	NNP
cord-006229-7yoilsho	3407	14	(	(	-LRB-
cord-006229-7yoilsho	3407	15	grant	grant	NN
cord-006229-7yoilsho	3407	16	agreement	agreement	NN
cord-006229-7yoilsho	3407	17	no	no	NN
cord-006229-7yoilsho	3407	18	.	.	NN
cord-006229-7yoilsho	3407	19	310187	310187	CD
cord-006229-7yoilsho	3407	20	)	)	-RRB-
cord-006229-7yoilsho	3407	21	,	,	,
cord-006229-7yoilsho	3407	22	therefore	therefore	RB
cord-006229-7yoilsho	3407	23	investigates	investigate	VBZ
cord-006229-7yoilsho	3407	24	e.g.	e.g.	IN
cord-006229-7yoilsho	3407	25	several	several	JJ
cord-006229-7yoilsho	3407	26	tailor	tailor	NN
cord-006229-7yoilsho	3407	27	-	-	HYPH
cord-006229-7yoilsho	3407	28	made	make	VBN
cord-006229-7yoilsho	3407	29	,	,	,
cord-006229-7yoilsho	3407	30	nano	nano	NN
cord-006229-7yoilsho	3407	31	-	-	HYPH
cord-006229-7yoilsho	3407	32	layered	layer	VBN
cord-006229-7yoilsho	3407	33	hybrid	hybrid	JJ
cord-006229-7yoilsho	3407	34	particles	particle	NNS
cord-006229-7yoilsho	3407	35	as	as	IN
cord-006229-7yoilsho	3407	36	alternatives	alternative	NNS
cord-006229-7yoilsho	3407	37	to	to	IN
cord-006229-7yoilsho	3407	38	HFR	HFR	NNP
cord-006229-7yoilsho	3407	39	additives	additive	NNS
cord-006229-7yoilsho	3407	40	.	.	.
cord-006229-7yoilsho	3408	1	Considering	consider	VBG
cord-006229-7yoilsho	3408	2	"	"	``
cord-006229-7yoilsho	3408	3	safer	safe	JJR
cord-006229-7yoilsho	3408	4	-	-	HYPH
cord-006229-7yoilsho	3408	5	bydesign	bydesign	NN
cord-006229-7yoilsho	3408	6	"	"	''
cord-006229-7yoilsho	3408	7	strategies	strategy	NNS
cord-006229-7yoilsho	3408	8	,	,	,
cord-006229-7yoilsho	3408	9	potential	potential	JJ
cord-006229-7yoilsho	3408	10	FR	fr	NN
cord-006229-7yoilsho	3408	11	nanomaterials	nanomaterial	NNS
cord-006229-7yoilsho	3408	12	(	(	-LRB-
cord-006229-7yoilsho	3408	13	NM	NM	NNP
cord-006229-7yoilsho	3408	14	)	)	-RRB-
cord-006229-7yoilsho	3408	15	were	be	VBD
cord-006229-7yoilsho	3408	16	physico	physico	NN
cord-006229-7yoilsho	3408	17	-	-	:
cord-006229-7yoilsho	3408	18	chemically	chemically	RB
cord-006229-7yoilsho	3408	19	characterized	characterize	VBN
cord-006229-7yoilsho	3408	20	(	(	-LRB-
cord-006229-7yoilsho	3408	21	e.g.	e.g.	RB
cord-006229-7yoilsho	3408	22	particle	particle	NN
cord-006229-7yoilsho	3408	23	size	size	NN
cord-006229-7yoilsho	3408	24	distribution	distribution	NN
cord-006229-7yoilsho	3408	25	,	,	,
cord-006229-7yoilsho	3408	26	zeta	zeta	NNP
cord-006229-7yoilsho	3408	27	potential	potential	NN
cord-006229-7yoilsho	3408	28	)	)	-RRB-
cord-006229-7yoilsho	3408	29	and	and	CC
cord-006229-7yoilsho	3408	30	screened	screen	VBN
cord-006229-7yoilsho	3408	31	early	early	RB
cord-006229-7yoilsho	3408	32	in	in	IN
cord-006229-7yoilsho	3408	33	development	development	NN
cord-006229-7yoilsho	3408	34	for	for	IN
cord-006229-7yoilsho	3408	35	their	-PRON-	PRP$
cord-006229-7yoilsho	3408	36	(	(	-LRB-
cord-006229-7yoilsho	3408	37	geno)toxic	geno)toxic	NNP
cord-006229-7yoilsho	3408	38	and	and	CC
cord-006229-7yoilsho	3408	39	pro	pro	JJ
cord-006229-7yoilsho	3408	40	-	-	JJ
cord-006229-7yoilsho	3408	41	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	3408	42	potential	potential	NN
cord-006229-7yoilsho	3408	43	to	to	TO
cord-006229-7yoilsho	3408	44	timely	timely	RB
cord-006229-7yoilsho	3408	45	reject	reject	VB
cord-006229-7yoilsho	3408	46	NM	NM	NNP
cord-006229-7yoilsho	3408	47	with	with	IN
cord-006229-7yoilsho	3408	48	high	high	JJ
cord-006229-7yoilsho	3408	49	health	health	NN
cord-006229-7yoilsho	3408	50	hazard	hazard	NN
cord-006229-7yoilsho	3408	51	.	.	.
cord-006229-7yoilsho	3409	1	As	as	IN
cord-006229-7yoilsho	3409	2	inhalation	inhalation	NN
cord-006229-7yoilsho	3409	3	is	be	VBZ
cord-006229-7yoilsho	3409	4	the	the	DT
cord-006229-7yoilsho	3409	5	most	most	RBS
cord-006229-7yoilsho	3409	6	important	important	JJ
cord-006229-7yoilsho	3409	7	exposure	exposure	NN
cord-006229-7yoilsho	3409	8	route	route	NN
cord-006229-7yoilsho	3409	9	for	for	IN
cord-006229-7yoilsho	3409	10	NM	NM	NNP
cord-006229-7yoilsho	3409	11	,	,	,
cord-006229-7yoilsho	3409	12	lungrelevant	lungrelevant	NN
cord-006229-7yoilsho	3409	13	cells	cell	NNS
cord-006229-7yoilsho	3409	14	were	be	VBD
cord-006229-7yoilsho	3409	15	used	use	VBN
cord-006229-7yoilsho	3409	16	as	as	IN
cord-006229-7yoilsho	3409	17	in	in	IN
cord-006229-7yoilsho	3409	18	vitro	vitro	FW
cord-006229-7yoilsho	3409	19	screening	screening	NN
cord-006229-7yoilsho	3409	20	models	model	NNS
cord-006229-7yoilsho	3409	21	.	.	.
cord-006229-7yoilsho	3410	1	To	to	TO
cord-006229-7yoilsho	3410	2	better	better	RB
cord-006229-7yoilsho	3410	3	enable	enable	VB
cord-006229-7yoilsho	3410	4	detection	detection	NN
cord-006229-7yoilsho	3410	5	and	and	CC
cord-006229-7yoilsho	3410	6	differentiation	differentiation	NN
cord-006229-7yoilsho	3410	7	of	of	IN
cord-006229-7yoilsho	3410	8	the	the	DT
cord-006229-7yoilsho	3410	9	biologic	biologic	JJ
cord-006229-7yoilsho	3410	10	effects	effect	NNS
cord-006229-7yoilsho	3410	11	of	of	IN
cord-006229-7yoilsho	3410	12	the	the	DT
cord-006229-7yoilsho	3410	13	most	most	RBS
cord-006229-7yoilsho	3410	14	promising	promising	JJ
cord-006229-7yoilsho	3410	15	NM	NM	NNP
cord-006229-7yoilsho	3410	16	,	,	,
cord-006229-7yoilsho	3410	17	screening	screening	NN
cord-006229-7yoilsho	3410	18	was	be	VBD
cord-006229-7yoilsho	3410	19	started	start	VBN
cord-006229-7yoilsho	3410	20	with	with	IN
cord-006229-7yoilsho	3410	21	primary	primary	JJ
cord-006229-7yoilsho	3410	22	rat	rat	NN
cord-006229-7yoilsho	3410	23	lung	lung	NN
cord-006229-7yoilsho	3410	24	alveolar	alveolar	NN
cord-006229-7yoilsho	3410	25	macrophages	macrophage	NNS
cord-006229-7yoilsho	3410	26	(	(	-LRB-
cord-006229-7yoilsho	3410	27	AM	am	NN
cord-006229-7yoilsho	3410	28	;	;	:
cord-006229-7yoilsho	3410	29	cells	cell	NNS
cord-006229-7yoilsho	3410	30	of	of	IN
cord-006229-7yoilsho	3410	31	first	first	JJ
cord-006229-7yoilsho	3410	32	contact	contact	NN
cord-006229-7yoilsho	3410	33	for	for	IN
cord-006229-7yoilsho	3410	34	inhaled	inhale	VBN
cord-006229-7yoilsho	3410	35	NM	NM	NNP
cord-006229-7yoilsho	3410	36	)	)	-RRB-
cord-006229-7yoilsho	3410	37	,	,	,
cord-006229-7yoilsho	3410	38	at	at	IN
cord-006229-7yoilsho	3410	39	a	a	DT
cord-006229-7yoilsho	3410	40	high	high	JJ
cord-006229-7yoilsho	3410	41	concentration	concentration	NN
cord-006229-7yoilsho	3410	42	of	of	IN
cord-006229-7yoilsho	3410	43	50µg	50µg	JJ
cord-006229-7yoilsho	3410	44	/	/	SYM
cord-006229-7yoilsho	3410	45	cm	cm	NN
cord-006229-7yoilsho	3410	46	2	2	CD
cord-006229-7yoilsho	3410	47	(	(	-LRB-
cord-006229-7yoilsho	3410	48	24h	24h	NNS
cord-006229-7yoilsho	3410	49	of	of	IN
cord-006229-7yoilsho	3410	50	incubation	incubation	NN
cord-006229-7yoilsho	3410	51	)	)	-RRB-
cord-006229-7yoilsho	3410	52	,	,	,
cord-006229-7yoilsho	3410	53	using	use	VBG
cord-006229-7yoilsho	3410	54	membrane	membrane	NN
cord-006229-7yoilsho	3410	55	damage	damage	NN
cord-006229-7yoilsho	3410	56	(	(	-LRB-
cord-006229-7yoilsho	3410	57	lactate	lactate	NN
cord-006229-7yoilsho	3410	58	dehydrogenase	dehydrogenase	NN
cord-006229-7yoilsho	3410	59	release	release	NN
cord-006229-7yoilsho	3410	60	assay	assay	NN
cord-006229-7yoilsho	3410	61	)	)	-RRB-
cord-006229-7yoilsho	3410	62	,	,	,
cord-006229-7yoilsho	3410	63	direct	direct	JJ
cord-006229-7yoilsho	3410	64	DNA	dna	NN
cord-006229-7yoilsho	3410	65	-	-	HYPH
cord-006229-7yoilsho	3410	66	damage	damage	NN
cord-006229-7yoilsho	3410	67	(	(	-LRB-
cord-006229-7yoilsho	3410	68	alkaline	alkaline	JJ
cord-006229-7yoilsho	3410	69	comet	comet	NN
cord-006229-7yoilsho	3410	70	assay	assay	NN
cord-006229-7yoilsho	3410	71	)	)	-RRB-
cord-006229-7yoilsho	3410	72	,	,	,
cord-006229-7yoilsho	3410	73	and	and	CC
cord-006229-7yoilsho	3410	74	IL-8	IL-8	NNP
cord-006229-7yoilsho	3410	75	liberation	liberation	NN
cord-006229-7yoilsho	3410	76	(	(	-LRB-
cord-006229-7yoilsho	3410	77	ELISA	ELISA	NNP
cord-006229-7yoilsho	3410	78	)	)	-RRB-
cord-006229-7yoilsho	3410	79	as	as	IN
cord-006229-7yoilsho	3410	80	primary	primary	JJ
cord-006229-7yoilsho	3410	81	endpoints	endpoint	NNS
cord-006229-7yoilsho	3410	82	,	,	,
cord-006229-7yoilsho	3410	83	and	and	CC
cord-006229-7yoilsho	3410	84	quartz	quartz	NN
cord-006229-7yoilsho	3410	85	DQ12	DQ12	NNP
cord-006229-7yoilsho	3410	86	and	and	CC
cord-006229-7yoilsho	3410	87	Al	Al	NNP
cord-006229-7yoilsho	3410	88	2	2	CD
cord-006229-7yoilsho	3410	89	O	O	NNP
cord-006229-7yoilsho	3410	90	3	3	CD
cord-006229-7yoilsho	3410	91	as	as	IN
cord-006229-7yoilsho	3410	92	particulate	particulate	NN
cord-006229-7yoilsho	3410	93	positive	positive	JJ
cord-006229-7yoilsho	3410	94	and	and	CC
cord-006229-7yoilsho	3410	95	negative	negative	JJ
cord-006229-7yoilsho	3410	96	controls	control	NNS
cord-006229-7yoilsho	3410	97	,	,	,
cord-006229-7yoilsho	3410	98	respectively	respectively	RB
cord-006229-7yoilsho	3410	99	.	.	.
cord-006229-7yoilsho	3411	1	In	in	IN
cord-006229-7yoilsho	3411	2	this	this	DT
cord-006229-7yoilsho	3411	3	screening	screening	NN
cord-006229-7yoilsho	3411	4	system	system	NN
cord-006229-7yoilsho	3411	5	,	,	,
cord-006229-7yoilsho	3411	6	biologically	biologically	RB
cord-006229-7yoilsho	3411	7	inert	inert	JJ
cord-006229-7yoilsho	3411	8	NM	NM	NNP
cord-006229-7yoilsho	3411	9	could	could	MD
cord-006229-7yoilsho	3411	10	be	be	VB
cord-006229-7yoilsho	3411	11	differentiated	differentiate	VBN
cord-006229-7yoilsho	3411	12	from	from	IN
cord-006229-7yoilsho	3411	13	more	more	JJR
cord-006229-7yoilsho	3411	14	active	active	JJ
cord-006229-7yoilsho	3411	15	ones	one	NNS
cord-006229-7yoilsho	3411	16	.	.	.
cord-006229-7yoilsho	3412	1	Thereby	thereby	RB
cord-006229-7yoilsho	3412	2	,	,	,
cord-006229-7yoilsho	3412	3	Mg(OH	Mg(OH	NNP
cord-006229-7yoilsho	3412	4	)	)	-RRB-
cord-006229-7yoilsho	3412	5	2	2	CD
cord-006229-7yoilsho	3412	6	nanoplatelets	nanoplatelet	NNS
cord-006229-7yoilsho	3412	7	(	(	-LRB-
cord-006229-7yoilsho	3412	8	Mg1	mg1	NN
cord-006229-7yoilsho	3412	9	;	;	:
cord-006229-7yoilsho	3412	10	mean	mean	VB
cord-006229-7yoilsho	3412	11	lateral	lateral	JJ
cord-006229-7yoilsho	3412	12	size	size	NN
cord-006229-7yoilsho	3412	13	:	:	:
cord-006229-7yoilsho	3412	14	1,5	1,5	CD
cord-006229-7yoilsho	3412	15	-	-	SYM
cord-006229-7yoilsho	3412	16	2	2	CD
cord-006229-7yoilsho	3412	17	µm	µm	CD
cord-006229-7yoilsho	3412	18	;	;	.
cord-006229-7yoilsho	3413	1	mean	mean	JJ
cord-006229-7yoilsho	3413	2	thickness	thickness	NN
cord-006229-7yoilsho	3413	3	:	:	:
cord-006229-7yoilsho	3413	4	15	15	CD
cord-006229-7yoilsho	3413	5	-	-	SYM
cord-006229-7yoilsho	3413	6	20	20	CD
cord-006229-7yoilsho	3413	7	nm	nm	NN
cord-006229-7yoilsho	3413	8	)	)	-RRB-
cord-006229-7yoilsho	3413	9	represented	represent	VBD
cord-006229-7yoilsho	3413	10	the	the	DT
cord-006229-7yoilsho	3413	11	least	least	JJS
cord-006229-7yoilsho	3413	12	,	,	,
cord-006229-7yoilsho	3413	13	and	and	CC
cord-006229-7yoilsho	3413	14	pristine	pristine	JJ
cord-006229-7yoilsho	3413	15	few	few	JJ
cord-006229-7yoilsho	3413	16	layers	layer	NNS
cord-006229-7yoilsho	3413	17	graphene	graphene	NN
cord-006229-7yoilsho	3413	18	nanoplatelets	nanoplatelets	NNP
cord-006229-7yoilsho	3413	19	(	(	-LRB-
cord-006229-7yoilsho	3413	20	GR1	GR1	NNP
cord-006229-7yoilsho	3413	21	;	;	:
cord-006229-7yoilsho	3413	22	mean	mean	VB
cord-006229-7yoilsho	3413	23	lateral	lateral	JJ
cord-006229-7yoilsho	3413	24	size	size	NN
cord-006229-7yoilsho	3413	25	:	:	:
cord-006229-7yoilsho	3413	26	2	2	CD
cord-006229-7yoilsho	3413	27	µm	µm	CD
cord-006229-7yoilsho	3413	28	;	;	:
cord-006229-7yoilsho	3413	29	mean	mean	VB
cord-006229-7yoilsho	3413	30	thickness	thickness	NN
cord-006229-7yoilsho	3413	31	:	:	:
cord-006229-7yoilsho	3413	32	3	3	CD
cord-006229-7yoilsho	3413	33	nm	nm	NN
cord-006229-7yoilsho	3413	34	;	;	:
cord-006229-7yoilsho	3413	35	graphene	graphene	NN
cord-006229-7yoilsho	3413	36	layers	layer	NNS
cord-006229-7yoilsho	3413	37	:	:	:
cord-006229-7yoilsho	3413	38	8	8	CD
cord-006229-7yoilsho	3413	39	±	±	CD
cord-006229-7yoilsho	3413	40	0.5	0.5	CD
cord-006229-7yoilsho	3413	41	)	)	-RRB-
cord-006229-7yoilsho	3413	42	the	the	DT
cord-006229-7yoilsho	3413	43	most	most	RBS
cord-006229-7yoilsho	3413	44	biologically	biologically	RB
cord-006229-7yoilsho	3413	45	active	active	JJ
cord-006229-7yoilsho	3413	46	NM	NM	NNP
cord-006229-7yoilsho	3413	47	.	.	.
cord-006229-7yoilsho	3414	1	Clear	clear	JJ
cord-006229-7yoilsho	3414	2	concentration	concentration	NN
cord-006229-7yoilsho	3414	3	dependencies	dependency	NNS
cord-006229-7yoilsho	3414	4	were	be	VBD
cord-006229-7yoilsho	3414	5	detected	detect	VBN
cord-006229-7yoilsho	3414	6	for	for	IN
cord-006229-7yoilsho	3414	7	GR1	GR1	NNP
cord-006229-7yoilsho	3414	8	in	in	IN
cord-006229-7yoilsho	3414	9	follow	follow	NN
cord-006229-7yoilsho	3414	10	-	-	HYPH
cord-006229-7yoilsho	3414	11	up	up	RP
cord-006229-7yoilsho	3414	12	experiments	experiment	NNS
cord-006229-7yoilsho	3414	13	.	.	.
cord-006229-7yoilsho	3415	1	Mg1	Mg1	NNP
cord-006229-7yoilsho	3415	2	and	and	CC
cord-006229-7yoilsho	3415	3	GR1	GR1	NNP
cord-006229-7yoilsho	3415	4	were	be	VBD
cord-006229-7yoilsho	3415	5	further	further	RB
cord-006229-7yoilsho	3415	6	tested	test	VBN
cord-006229-7yoilsho	3415	7	in	in	IN
cord-006229-7yoilsho	3415	8	other	other	JJ
cord-006229-7yoilsho	3415	9	lung	lung	NN
cord-006229-7yoilsho	3415	10	-	-	HYPH
cord-006229-7yoilsho	3415	11	relevant	relevant	JJ
cord-006229-7yoilsho	3415	12	cell	cell	NN
cord-006229-7yoilsho	3415	13	types	type	NNS
cord-006229-7yoilsho	3415	14	,	,	,
cord-006229-7yoilsho	3415	15	i.e.	i.e.	FW
cord-006229-7yoilsho	3415	16	MRC-5	MRC-5	NNP
cord-006229-7yoilsho	3415	17	primary	primary	JJ
cord-006229-7yoilsho	3415	18	human	human	JJ
cord-006229-7yoilsho	3415	19	lung	lung	NN
cord-006229-7yoilsho	3415	20	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	3415	21	and	and	CC
cord-006229-7yoilsho	3415	22	A549	a549	JJ
cord-006229-7yoilsho	3415	23	lung	lung	NN
cord-006229-7yoilsho	3415	24	adenocarcinoma	adenocarcinoma	NN
cord-006229-7yoilsho	3415	25	epithelial	epithelial	JJ
cord-006229-7yoilsho	3415	26	cells	cell	NNS
cord-006229-7yoilsho	3415	27	.	.	.
cord-006229-7yoilsho	3416	1	Interestingly	interestingly	RB
cord-006229-7yoilsho	3416	2	,	,	,
cord-006229-7yoilsho	3416	3	MRC-5	MRC-5	NNP
cord-006229-7yoilsho	3416	4	cells	cell	NNS
cord-006229-7yoilsho	3416	5	were	be	VBD
cord-006229-7yoilsho	3416	6	less	less	RBR
cord-006229-7yoilsho	3416	7	sensitive	sensitive	JJ
cord-006229-7yoilsho	3416	8	towards	towards	IN
cord-006229-7yoilsho	3416	9	biological	biological	JJ
cord-006229-7yoilsho	3416	10	effects	effect	NNS
cord-006229-7yoilsho	3416	11	of	of	IN
cord-006229-7yoilsho	3416	12	GR1	GR1	NNP
cord-006229-7yoilsho	3416	13	,	,	,
cord-006229-7yoilsho	3416	14	compared	compare	VBN
cord-006229-7yoilsho	3416	15	to	to	IN
cord-006229-7yoilsho	3416	16	AM	am	NN
cord-006229-7yoilsho	3416	17	,	,	,
cord-006229-7yoilsho	3416	18	whereas	whereas	IN
cord-006229-7yoilsho	3416	19	A549	a549	JJ
cord-006229-7yoilsho	3416	20	cells	cell	NNS
cord-006229-7yoilsho	3416	21	showed	show	VBD
cord-006229-7yoilsho	3416	22	nearly	nearly	RB
cord-006229-7yoilsho	3416	23	no	no	DT
cord-006229-7yoilsho	3416	24	effect	effect	NN
cord-006229-7yoilsho	3416	25	,	,	,
cord-006229-7yoilsho	3416	26	keeping	keep	VBG
cord-006229-7yoilsho	3416	27	in	in	IN
cord-006229-7yoilsho	3416	28	mind	mind	NN
cord-006229-7yoilsho	3416	29	that	that	IN
cord-006229-7yoilsho	3416	30	lung	lung	NN
cord-006229-7yoilsho	3416	31	epithelial	epithelial	JJ
cord-006229-7yoilsho	3416	32	cells	cell	NNS
cord-006229-7yoilsho	3416	33	are	be	VBP
cord-006229-7yoilsho	3416	34	the	the	DT
cord-006229-7yoilsho	3416	35	target	target	NN
cord-006229-7yoilsho	3416	36	cells	cell	NNS
cord-006229-7yoilsho	3416	37	of	of	IN
cord-006229-7yoilsho	3416	38	lung	lung	NN
cord-006229-7yoilsho	3416	39	tumor	tumor	NN
cord-006229-7yoilsho	3416	40	development	development	NN
cord-006229-7yoilsho	3416	41	.	.	.
cord-006229-7yoilsho	3417	1	To	to	TO
cord-006229-7yoilsho	3417	2	test	test	VB
cord-006229-7yoilsho	3417	3	the	the	DT
cord-006229-7yoilsho	3417	4	hypothesis	hypothesis	NN
cord-006229-7yoilsho	3417	5	that	that	IN
cord-006229-7yoilsho	3417	6	the	the	DT
cord-006229-7yoilsho	3417	7	observed	observed	JJ
cord-006229-7yoilsho	3417	8	cellspecific	cellspecific	NN
cord-006229-7yoilsho	3417	9	differences	difference	NNS
cord-006229-7yoilsho	3417	10	in	in	IN
cord-006229-7yoilsho	3417	11	sensitivity	sensitivity	NN
cord-006229-7yoilsho	3417	12	might	might	NN
cord-006229-7yoilsho	3417	13	in	in	IN
cord-006229-7yoilsho	3417	14	part	part	NN
cord-006229-7yoilsho	3417	15	be	be	VB
cord-006229-7yoilsho	3417	16	based	base	VBN
cord-006229-7yoilsho	3417	17	on	on	IN
cord-006229-7yoilsho	3417	18	cellular	cellular	JJ
cord-006229-7yoilsho	3417	19	uptake	uptake	NN
cord-006229-7yoilsho	3417	20	,	,	,
cord-006229-7yoilsho	3417	21	cells	cell	NNS
cord-006229-7yoilsho	3417	22	were	be	VBD
cord-006229-7yoilsho	3417	23	exposed	expose	VBN
cord-006229-7yoilsho	3417	24	for	for	IN
cord-006229-7yoilsho	3417	25	24	24	CD
cord-006229-7yoilsho	3417	26	h	h	NN
cord-006229-7yoilsho	3417	27	to	to	IN
cord-006229-7yoilsho	3417	28	12.5	12.5	CD
cord-006229-7yoilsho	3417	29	or	or	CC
cord-006229-7yoilsho	3417	30	25	25	CD
cord-006229-7yoilsho	3417	31	µg	µg	NN
cord-006229-7yoilsho	3417	32	/	/	SYM
cord-006229-7yoilsho	3417	33	cm	cm	NNP
cord-006229-7yoilsho	3417	34	2	2	CD
cord-006229-7yoilsho	3417	35	of	of	IN
cord-006229-7yoilsho	3417	36	GR1	GR1	NNP
cord-006229-7yoilsho	3417	37	on	on	IN
cord-006229-7yoilsho	3417	38	chamber	chamber	NN
cord-006229-7yoilsho	3417	39	slides	slide	NNS
cord-006229-7yoilsho	3417	40	.	.	.
cord-006229-7yoilsho	3418	1	Slides	slide	NNS
cord-006229-7yoilsho	3418	2	were	be	VBD
cord-006229-7yoilsho	3418	3	finally	finally	RB
cord-006229-7yoilsho	3418	4	stained	stain	VBN
cord-006229-7yoilsho	3418	5	with	with	IN
cord-006229-7yoilsho	3418	6	DAPI	DAPI	NNP
cord-006229-7yoilsho	3418	7	and	and	CC
cord-006229-7yoilsho	3418	8	analyzed	analyze	VBN
cord-006229-7yoilsho	3418	9	by	by	IN
cord-006229-7yoilsho	3418	10	dark	dark	JJ
cord-006229-7yoilsho	3418	11	field	field	NN
cord-006229-7yoilsho	3418	12	microscopy	microscopy	NNS
cord-006229-7yoilsho	3418	13	.	.	.
cord-006229-7yoilsho	3419	1	Cells	cell	NNS
cord-006229-7yoilsho	3419	2	indeed	indeed	RB
cord-006229-7yoilsho	3419	3	demonstrated	demonstrate	VBD
cord-006229-7yoilsho	3419	4	differences	difference	NNS
cord-006229-7yoilsho	3419	5	in	in	IN
cord-006229-7yoilsho	3419	6	uptake	uptake	NN
cord-006229-7yoilsho	3419	7	capacity	capacity	NN
cord-006229-7yoilsho	3419	8	and	and	CC
cord-006229-7yoilsho	3419	9	also	also	RB
cord-006229-7yoilsho	3419	10	showed	show	VBD
cord-006229-7yoilsho	3419	11	unique	unique	JJ
cord-006229-7yoilsho	3419	12	pattern	pattern	NN
cord-006229-7yoilsho	3419	13	of	of	IN
cord-006229-7yoilsho	3419	14	cellular	cellular	JJ
cord-006229-7yoilsho	3419	15	localization	localization	NN
cord-006229-7yoilsho	3419	16	of	of	IN
cord-006229-7yoilsho	3419	17	GR1	GR1	NNP
cord-006229-7yoilsho	3419	18	,	,	,
cord-006229-7yoilsho	3419	19	i.e.	i.e.	FW
cord-006229-7yoilsho	3419	20	with	with	IN
cord-006229-7yoilsho	3419	21	tight	tight	JJ
cord-006229-7yoilsho	3419	22	perinuclear	perinuclear	JJ
cord-006229-7yoilsho	3419	23	agglomeration	agglomeration	NN
cord-006229-7yoilsho	3419	24	in	in	IN
cord-006229-7yoilsho	3419	25	AM	AM	NNP
cord-006229-7yoilsho	3419	26	,	,	,
cord-006229-7yoilsho	3419	27	a	a	DT
cord-006229-7yoilsho	3419	28	more	more	RBR
cord-006229-7yoilsho	3419	29	scattered	scattered	JJ
cord-006229-7yoilsho	3419	30	cytoplasmic	cytoplasmic	JJ
cord-006229-7yoilsho	3419	31	distribution	distribution	NN
cord-006229-7yoilsho	3419	32	in	in	IN
cord-006229-7yoilsho	3419	33	MRC-5	MRC-5	NNP
cord-006229-7yoilsho	3419	34	cells	cell	NNS
cord-006229-7yoilsho	3419	35	and	and	CC
cord-006229-7yoilsho	3419	36	limited	limited	JJ
cord-006229-7yoilsho	3419	37	uptake	uptake	NN
cord-006229-7yoilsho	3419	38	in	in	IN
cord-006229-7yoilsho	3419	39	A549	a549	JJ
cord-006229-7yoilsho	3419	40	cells	cell	NNS
cord-006229-7yoilsho	3419	41	.	.	.
cord-006229-7yoilsho	3420	1	Additionally	additionally	RB
cord-006229-7yoilsho	3420	2	,	,	,
cord-006229-7yoilsho	3420	3	biological	biological	JJ
cord-006229-7yoilsho	3420	4	activity	activity	NN
cord-006229-7yoilsho	3420	5	of	of	IN
cord-006229-7yoilsho	3420	6	the	the	DT
cord-006229-7yoilsho	3420	7	diverse	diverse	JJ
cord-006229-7yoilsho	3420	8	NM	NM	NNP
cord-006229-7yoilsho	3420	9	seemed	seem	VBD
cord-006229-7yoilsho	3420	10	also	also	RB
cord-006229-7yoilsho	3420	11	to	to	TO
cord-006229-7yoilsho	3420	12	correlate	correlate	VB
cord-006229-7yoilsho	3420	13	with	with	IN
cord-006229-7yoilsho	3420	14	cellular	cellular	JJ
cord-006229-7yoilsho	3420	15	uptake	uptake	NN
cord-006229-7yoilsho	3420	16	,	,	,
cord-006229-7yoilsho	3420	17	as	as	IN
cord-006229-7yoilsho	3420	18	determined	determine	VBN
cord-006229-7yoilsho	3420	19	by	by	IN
cord-006229-7yoilsho	3420	20	light	light	JJ
cord-006229-7yoilsho	3420	21	and	and	CC
cord-006229-7yoilsho	3420	22	dark	dark	JJ
cord-006229-7yoilsho	3420	23	field	field	NN
cord-006229-7yoilsho	3420	24	microscopy	microscopy	NNS
cord-006229-7yoilsho	3420	25	in	in	IN
cord-006229-7yoilsho	3420	26	AM	am	NN
cord-006229-7yoilsho	3420	27	and	and	CC
cord-006229-7yoilsho	3420	28	MRC-5	MRC-5	NNP
cord-006229-7yoilsho	3420	29	cells	cell	NNS
cord-006229-7yoilsho	3420	30	.	.	.
cord-006229-7yoilsho	3421	1	In	in	IN
cord-006229-7yoilsho	3421	2	conclusion	conclusion	NN
cord-006229-7yoilsho	3421	3	,	,	,
cord-006229-7yoilsho	3421	4	an	an	DT
cord-006229-7yoilsho	3421	5	AM	am	NN
cord-006229-7yoilsho	3421	6	-	-	HYPH
cord-006229-7yoilsho	3421	7	based	base	VBN
cord-006229-7yoilsho	3421	8	screening	screening	NN
cord-006229-7yoilsho	3421	9	system	system	NN
cord-006229-7yoilsho	3421	10	was	be	VBD
cord-006229-7yoilsho	3421	11	able	able	JJ
cord-006229-7yoilsho	3421	12	to	to	TO
cord-006229-7yoilsho	3421	13	differentiate	differentiate	VB
cord-006229-7yoilsho	3421	14	biological	biological	JJ
cord-006229-7yoilsho	3421	15	activity	activity	NN
cord-006229-7yoilsho	3421	16	of	of	IN
cord-006229-7yoilsho	3421	17	diverse	diverse	JJ
cord-006229-7yoilsho	3421	18	NM	NM	NNP
cord-006229-7yoilsho	3421	19	,	,	,
cord-006229-7yoilsho	3421	20	with	with	IN
cord-006229-7yoilsho	3421	21	morphology	morphology	NN
cord-006229-7yoilsho	3421	22	,	,	,
cord-006229-7yoilsho	3421	23	physico	physico	NN
cord-006229-7yoilsho	3421	24	-	-	HYPH
cord-006229-7yoilsho	3421	25	chemical	chemical	NN
cord-006229-7yoilsho	3421	26	characteristics	characteristic	NNS
cord-006229-7yoilsho	3421	27	,	,	,
cord-006229-7yoilsho	3421	28	and	and	CC
cord-006229-7yoilsho	3421	29	related	relate	VBN
cord-006229-7yoilsho	3421	30	cellular	cellular	JJ
cord-006229-7yoilsho	3421	31	uptake	uptake	NN
cord-006229-7yoilsho	3421	32	most	most	RBS
cord-006229-7yoilsho	3421	33	likely	likely	JJ
cord-006229-7yoilsho	3421	34	to	to	TO
cord-006229-7yoilsho	3421	35	be	be	VB
cord-006229-7yoilsho	3421	36	key	key	JJ
cord-006229-7yoilsho	3421	37	for	for	IN
cord-006229-7yoilsho	3421	38	NM	NM	NNP
cord-006229-7yoilsho	3421	39	-	-	:
cord-006229-7yoilsho	3421	40	and	and	CC
cord-006229-7yoilsho	3421	41	cell	cell	NN
cord-006229-7yoilsho	3421	42	type	type	NN
cord-006229-7yoilsho	3421	43	-	-	HYPH
cord-006229-7yoilsho	3421	44	specific	specific	JJ
cord-006229-7yoilsho	3421	45	hazard	hazard	NN
cord-006229-7yoilsho	3421	46	.	.	.
cord-006229-7yoilsho	3422	1	Lung	lung	NN
cord-006229-7yoilsho	3422	2	carcinogenicity	carcinogenicity	NN
cord-006229-7yoilsho	3422	3	and	and	CC
cord-006229-7yoilsho	3422	4	putative	putative	JJ
cord-006229-7yoilsho	3422	5	systemic	systemic	JJ
cord-006229-7yoilsho	3422	6	effects	effect	NNS
cord-006229-7yoilsho	3422	7	of	of	IN
cord-006229-7yoilsho	3422	8	low	low	JJ
cord-006229-7yoilsho	3422	9	-	-	HYPH
cord-006229-7yoilsho	3422	10	dose	dose	NN
cord-006229-7yoilsho	3422	11	life	life	NN
cord-006229-7yoilsho	3422	12	-	-	HYPH
cord-006229-7yoilsho	3422	13	time	time	NN
cord-006229-7yoilsho	3422	14	inhalation	inhalation	NN
cord-006229-7yoilsho	3422	15	exposure	exposure	NN
cord-006229-7yoilsho	3422	16	to	to	IN
cord-006229-7yoilsho	3422	17	biopersistent	biopersistent	NN
cord-006229-7yoilsho	3422	18	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	3422	19	were	be	VBD
cord-006229-7yoilsho	3422	20	examined	examine	VBN
cord-006229-7yoilsho	3422	21	in	in	IN
cord-006229-7yoilsho	3422	22	a	a	DT
cord-006229-7yoilsho	3422	23	chronic	chronic	JJ
cord-006229-7yoilsho	3422	24	inhalation	inhalation	NN
cord-006229-7yoilsho	3422	25	study	study	NN
cord-006229-7yoilsho	3422	26	performed	perform	VBN
cord-006229-7yoilsho	3422	27	according	accord	VBG
cord-006229-7yoilsho	3422	28	to	to	IN
cord-006229-7yoilsho	3422	29	OECD	OECD	NNP
cord-006229-7yoilsho	3422	30	test	test	NN
cord-006229-7yoilsho	3422	31	guideline	guideline	NN
cord-006229-7yoilsho	3422	32	no	no	NN
cord-006229-7yoilsho	3422	33	.	.	.
cord-006229-7yoilsho	3423	1	453	453	CD
cord-006229-7yoilsho	3423	2	with	with	IN
cord-006229-7yoilsho	3423	3	several	several	JJ
cord-006229-7yoilsho	3423	4	protocol	protocol	NN
cord-006229-7yoilsho	3423	5	extensions	extension	NNS
cord-006229-7yoilsho	3423	6	.	.	.
cord-006229-7yoilsho	3424	1	Female	female	JJ
cord-006229-7yoilsho	3424	2	rats	rat	NNS
cord-006229-7yoilsho	3424	3	(	(	-LRB-
cord-006229-7yoilsho	3424	4	100	100	CD
cord-006229-7yoilsho	3424	5	/	/	SYM
cord-006229-7yoilsho	3424	6	group	group	NN
cord-006229-7yoilsho	3424	7	)	)	-RRB-
cord-006229-7yoilsho	3424	8	were	be	VBD
cord-006229-7yoilsho	3424	9	exposed	expose	VBN
cord-006229-7yoilsho	3424	10	to	to	IN
cord-006229-7yoilsho	3424	11	cerium	cerium	NN
cord-006229-7yoilsho	3424	12	dioxide	dioxide	NN
cord-006229-7yoilsho	3424	13	(	(	-LRB-
cord-006229-7yoilsho	3424	14	NM-212	NM-212	NNP
cord-006229-7yoilsho	3424	15	,	,	,
cord-006229-7yoilsho	3424	16	0.1	0.1	CD
cord-006229-7yoilsho	3424	17	;	;	:
cord-006229-7yoilsho	3424	18	0.3	0.3	CD
cord-006229-7yoilsho	3424	19	;	;	:
cord-006229-7yoilsho	3424	20	1	1	CD
cord-006229-7yoilsho	3424	21	;	;	:
cord-006229-7yoilsho	3424	22	3	3	CD
cord-006229-7yoilsho	3424	23	mg	mg	NN
cord-006229-7yoilsho	3424	24	/	/	SYM
cord-006229-7yoilsho	3424	25	m³	m³	NN
cord-006229-7yoilsho	3424	26	)	)	-RRB-
cord-006229-7yoilsho	3424	27	for	for	IN
cord-006229-7yoilsho	3424	28	two	two	CD
cord-006229-7yoilsho	3424	29	years	year	NNS
cord-006229-7yoilsho	3424	30	;	;	:
cord-006229-7yoilsho	3424	31	a	a	DT
cord-006229-7yoilsho	3424	32	control	control	NN
cord-006229-7yoilsho	3424	33	group	group	NN
cord-006229-7yoilsho	3424	34	was	be	VBD
cord-006229-7yoilsho	3424	35	exposed	expose	VBN
cord-006229-7yoilsho	3424	36	to	to	TO
cord-006229-7yoilsho	3424	37	clean	clean	JJ
cord-006229-7yoilsho	3424	38	air	air	NN
cord-006229-7yoilsho	3424	39	.	.	.
cord-006229-7yoilsho	3425	1	After	after	IN
cord-006229-7yoilsho	3425	2	one	one	CD
cord-006229-7yoilsho	3425	3	year	year	NN
cord-006229-7yoilsho	3425	4	exposure	exposure	NN
cord-006229-7yoilsho	3425	5	,	,	,
cord-006229-7yoilsho	3425	6	42	42	CD
cord-006229-7yoilsho	3425	7	µg	µg	NN
cord-006229-7yoilsho	3425	8	/	/	SYM
cord-006229-7yoilsho	3425	9	lung	lung	NN
cord-006229-7yoilsho	3425	10	was	be	VBD
cord-006229-7yoilsho	3425	11	found	find	VBN
cord-006229-7yoilsho	3425	12	in	in	IN
cord-006229-7yoilsho	3425	13	animals	animal	NNS
cord-006229-7yoilsho	3425	14	exposed	expose	VBN
cord-006229-7yoilsho	3425	15	to	to	IN
cord-006229-7yoilsho	3425	16	0.1	0.1	CD
cord-006229-7yoilsho	3425	17	mg	mg	NN
cord-006229-7yoilsho	3425	18	/	/	SYM
cord-006229-7yoilsho	3425	19	m³	m³	NNP
cord-006229-7yoilsho	3425	20	and	and	CC
cord-006229-7yoilsho	3425	21	2.6	2.6	CD
cord-006229-7yoilsho	3425	22	mg	mg	NN
cord-006229-7yoilsho	3425	23	/	/	SYM
cord-006229-7yoilsho	3425	24	lung	lung	NN
cord-006229-7yoilsho	3425	25	in	in	IN
cord-006229-7yoilsho	3425	26	animals	animal	NNS
cord-006229-7yoilsho	3425	27	exposed	expose	VBN
cord-006229-7yoilsho	3425	28	to	to	IN
cord-006229-7yoilsho	3425	29	3	3	CD
cord-006229-7yoilsho	3425	30	mg	mg	NN
cord-006229-7yoilsho	3425	31	/	/	SYM
cord-006229-7yoilsho	3425	32	m³.	m³.	VBZ
cord-006229-7yoilsho	3425	33	Histological	Histological	NNP
cord-006229-7yoilsho	3425	34	examination	examination	NN
cord-006229-7yoilsho	3425	35	of	of	IN
cord-006229-7yoilsho	3425	36	lungs	lung	NNS
cord-006229-7yoilsho	3425	37	revealed	reveal	VBD
cord-006229-7yoilsho	3425	38	several	several	JJ
cord-006229-7yoilsho	3425	39	adverse	adverse	JJ
cord-006229-7yoilsho	3425	40	and	and	CC
cord-006229-7yoilsho	3425	41	non	non	JJ
cord-006229-7yoilsho	3425	42	-	-	JJ
cord-006229-7yoilsho	3425	43	adverse	adverse	JJ
cord-006229-7yoilsho	3425	44	effects	effect	NNS
cord-006229-7yoilsho	3425	45	in	in	IN
cord-006229-7yoilsho	3425	46	the	the	DT
cord-006229-7yoilsho	3425	47	lung	lung	NN
cord-006229-7yoilsho	3425	48	.	.	.
cord-006229-7yoilsho	3426	1	The	the	DT
cord-006229-7yoilsho	3426	2	non	non	JJ
cord-006229-7yoilsho	3426	3	-	-	JJ
cord-006229-7yoilsho	3426	4	adverse	adverse	JJ
cord-006229-7yoilsho	3426	5	effects	effect	NNS
cord-006229-7yoilsho	3426	6	comprised	comprise	VBN
cord-006229-7yoilsho	3426	7	accumulation	accumulation	NN
cord-006229-7yoilsho	3426	8	of	of	IN
cord-006229-7yoilsho	3426	9	particle	particle	NN
cord-006229-7yoilsho	3426	10	-	-	HYPH
cord-006229-7yoilsho	3426	11	laden	laden	JJ
cord-006229-7yoilsho	3426	12	macrophages	macrophage	NNS
cord-006229-7yoilsho	3426	13	in	in	IN
cord-006229-7yoilsho	3426	14	alveolar	alveolar	NN
cord-006229-7yoilsho	3426	15	/	/	SYM
cord-006229-7yoilsho	3426	16	interstitial	interstitial	JJ
cord-006229-7yoilsho	3426	17	areas	area	NNS
cord-006229-7yoilsho	3426	18	and	and	CC
cord-006229-7yoilsho	3426	19	in	in	IN
cord-006229-7yoilsho	3426	20	the	the	DT
cord-006229-7yoilsho	3426	21	BALT	BALT	NNP
cord-006229-7yoilsho	3426	22	,	,	,
cord-006229-7yoilsho	3426	23	particle	particle	NN
cord-006229-7yoilsho	3426	24	-	-	HYPH
cord-006229-7yoilsho	3426	25	laden	laden	JJ
cord-006229-7yoilsho	3426	26	syncytial	syncytial	JJ
cord-006229-7yoilsho	3426	27	giant	giant	JJ
cord-006229-7yoilsho	3426	28	cells	cell	NNS
cord-006229-7yoilsho	3426	29	in	in	IN
cord-006229-7yoilsho	3426	30	the	the	DT
cord-006229-7yoilsho	3426	31	BALT	BALT	NNP
cord-006229-7yoilsho	3426	32	and	and	CC
cord-006229-7yoilsho	3426	33	bronchiolo	bronchiolo	JJ
cord-006229-7yoilsho	3426	34	-	-	HYPH
cord-006229-7yoilsho	3426	35	alveolar	alveolar	JJ
cord-006229-7yoilsho	3426	36	hyperplasia	hyperplasia	NN
cord-006229-7yoilsho	3426	37	(	(	-LRB-
cord-006229-7yoilsho	3426	38	alveolar	alveolar	NNP
cord-006229-7yoilsho	3426	39	bronchiolization	bronchiolization	NN
cord-006229-7yoilsho	3426	40	)	)	-RRB-
cord-006229-7yoilsho	3426	41	.	.	.
cord-006229-7yoilsho	3427	1	The	the	DT
cord-006229-7yoilsho	3427	2	adverse	adverse	JJ
cord-006229-7yoilsho	3427	3	effects	effect	NNS
cord-006229-7yoilsho	3427	4	included	include	VBN
cord-006229-7yoilsho	3427	5	(	(	-LRB-
cord-006229-7yoilsho	3427	6	mixed	mixed	JJ
cord-006229-7yoilsho	3427	7	)	)	-RRB-
cord-006229-7yoilsho	3427	8	alveolar	alveolar	JJ
cord-006229-7yoilsho	3427	9	/	/	SYM
cord-006229-7yoilsho	3427	10	interstitial	interstitial	JJ
cord-006229-7yoilsho	3427	11	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	3427	12	cell	cell	NN
cord-006229-7yoilsho	3427	13	infiltration	infiltration	NN
cord-006229-7yoilsho	3427	14	,	,	,
cord-006229-7yoilsho	3427	15	alveolar	alveolar	NN
cord-006229-7yoilsho	3427	16	/	/	SYM
cord-006229-7yoilsho	3427	17	interstitial	interstitial	JJ
cord-006229-7yoilsho	3427	18	granulomatous	granulomatous	JJ
cord-006229-7yoilsho	3427	19	inflammation	inflammation	NN
cord-006229-7yoilsho	3427	20	,	,	,
cord-006229-7yoilsho	3427	21	interstitial	interstitial	JJ
cord-006229-7yoilsho	3427	22	fibrosis	fibrosis	NN
cord-006229-7yoilsho	3427	23	and	and	CC
cord-006229-7yoilsho	3427	24	alveolar	alveolar	NNP
cord-006229-7yoilsho	3427	25	lipoproteinosis	lipoproteinosis	NNP
cord-006229-7yoilsho	3427	26	.	.	.
cord-006229-7yoilsho	3428	1	The	the	DT
cord-006229-7yoilsho	3428	2	incidence	incidence	NN
cord-006229-7yoilsho	3428	3	and	and	CC
cord-006229-7yoilsho	3428	4	severity	severity	NN
cord-006229-7yoilsho	3428	5	of	of	IN
cord-006229-7yoilsho	3428	6	the	the	DT
cord-006229-7yoilsho	3428	7	effects	effect	NNS
cord-006229-7yoilsho	3428	8	were	be	VBD
cord-006229-7yoilsho	3428	9	concentration	concentration	NN
cord-006229-7yoilsho	3428	10	-	-	HYPH
cord-006229-7yoilsho	3428	11	related	relate	VBN
cord-006229-7yoilsho	3428	12	.	.	.
cord-006229-7yoilsho	3429	1	Alveolar	Alveolar	NNP
cord-006229-7yoilsho	3429	2	lipoproteinosis	lipoproteinosis	NN
cord-006229-7yoilsho	3429	3	was	be	VBD
cord-006229-7yoilsho	3429	4	not	not	RB
cord-006229-7yoilsho	3429	5	observed	observe	VBN
cord-006229-7yoilsho	3429	6	at	at	IN
cord-006229-7yoilsho	3429	7	low	low	JJ
cord-006229-7yoilsho	3429	8	concentrations	concentration	NNS
cord-006229-7yoilsho	3429	9	of	of	IN
cord-006229-7yoilsho	3429	10	0.1	0.1	CD
cord-006229-7yoilsho	3429	11	and	and	CC
cord-006229-7yoilsho	3429	12	0.3	0.3	CD
cord-006229-7yoilsho	3429	13	mg	mg	NNP
cord-006229-7yoilsho	3429	14	/	/	SYM
cord-006229-7yoilsho	3429	15	m³	m³	NNP
cord-006229-7yoilsho	3429	16	CeO	ceo	NN
cord-006229-7yoilsho	3429	17	2	2	CD
cord-006229-7yoilsho	3429	18	.	.	.
cord-006229-7yoilsho	3430	1	Neither	neither	DT
cord-006229-7yoilsho	3430	2	pre	pre	JJ
cord-006229-7yoilsho	3430	3	-	-	JJ
cord-006229-7yoilsho	3430	4	neoplastic	neoplastic	JJ
cord-006229-7yoilsho	3430	5	nor	nor	CC
cord-006229-7yoilsho	3430	6	neoplastic	neoplastic	JJ
cord-006229-7yoilsho	3430	7	changes	change	NNS
cord-006229-7yoilsho	3430	8	were	be	VBD
cord-006229-7yoilsho	3430	9	observed	observe	VBN
cord-006229-7yoilsho	3430	10	after	after	IN
cord-006229-7yoilsho	3430	11	12-months	12-months	CD
cord-006229-7yoilsho	3430	12	exposure	exposure	NN
cord-006229-7yoilsho	3430	13	.	.	.
cord-006229-7yoilsho	3431	1	A	a	DT
cord-006229-7yoilsho	3431	2	no	no	DT
cord-006229-7yoilsho	3431	3	observed	observed	JJ
cord-006229-7yoilsho	3431	4	adverse	adverse	JJ
cord-006229-7yoilsho	3431	5	effect	effect	NN
cord-006229-7yoilsho	3431	6	concentration	concentration	NN
cord-006229-7yoilsho	3431	7	could	could	MD
cord-006229-7yoilsho	3431	8	not	not	RB
cord-006229-7yoilsho	3431	9	be	be	VB
cord-006229-7yoilsho	3431	10	established	establish	VBN
cord-006229-7yoilsho	3431	11	in	in	IN
cord-006229-7yoilsho	3431	12	this	this	DT
cord-006229-7yoilsho	3431	13	study	study	NN
cord-006229-7yoilsho	3431	14	.	.	.
cord-006229-7yoilsho	3432	1	The	the	DT
cord-006229-7yoilsho	3432	2	comprehensive	comprehensive	JJ
cord-006229-7yoilsho	3432	3	histopathological	histopathological	JJ
cord-006229-7yoilsho	3432	4	examinations	examination	NNS
cord-006229-7yoilsho	3432	5	of	of	IN
cord-006229-7yoilsho	3432	6	lungs	lung	NNS
cord-006229-7yoilsho	3432	7	and	and	CC
cord-006229-7yoilsho	3432	8	other	other	JJ
cord-006229-7yoilsho	3432	9	tissues	tissue	NNS
cord-006229-7yoilsho	3432	10	will	will	MD
cord-006229-7yoilsho	3432	11	be	be	VB
cord-006229-7yoilsho	3432	12	finalized	finalize	VBN
cord-006229-7yoilsho	3432	13	in	in	IN
cord-006229-7yoilsho	3432	14	2017	2017	CD
cord-006229-7yoilsho	3432	15	.	.	.
cord-006229-7yoilsho	3433	1	This	this	DT
cord-006229-7yoilsho	3433	2	project	project	NN
cord-006229-7yoilsho	3433	3	is	be	VBZ
cord-006229-7yoilsho	3433	4	part	part	NN
cord-006229-7yoilsho	3433	5	of	of	IN
cord-006229-7yoilsho	3433	6	the	the	DT
cord-006229-7yoilsho	3433	7	EU	EU	NNP
cord-006229-7yoilsho	3433	8	Project	Project	NNP
cord-006229-7yoilsho	3433	9	NanoReg	NanoReg	NNP
cord-006229-7yoilsho	3433	10	.	.	.
cord-006229-7yoilsho	3434	1	Moreover	moreover	RB
cord-006229-7yoilsho	3434	2	,	,	,
cord-006229-7yoilsho	3434	3	German	German	NNP
cord-006229-7yoilsho	3434	4	Federal	Federal	NNP
cord-006229-7yoilsho	3434	5	Ministry	Ministry	NNP
cord-006229-7yoilsho	3434	6	for	for	IN
cord-006229-7yoilsho	3434	7	the	the	DT
cord-006229-7yoilsho	3434	8	Environment	Environment	NNP
cord-006229-7yoilsho	3434	9	,	,	,
cord-006229-7yoilsho	3434	10	Nature	Nature	NNP
cord-006229-7yoilsho	3434	11	Conservation	Conservation	NNP
cord-006229-7yoilsho	3434	12	,	,	,
cord-006229-7yoilsho	3434	13	Building	Building	NNP
cord-006229-7yoilsho	3434	14	and	and	CC
cord-006229-7yoilsho	3434	15	Nuclear	Nuclear	NNP
cord-006229-7yoilsho	3434	16	Safety	Safety	NNP
cord-006229-7yoilsho	3434	17	,	,	,
cord-006229-7yoilsho	3434	18	German	German	NNP
cord-006229-7yoilsho	3434	19	Federal	Federal	NNP
cord-006229-7yoilsho	3434	20	Institute	Institute	NNP
cord-006229-7yoilsho	3434	21	for	for	IN
cord-006229-7yoilsho	3434	22	Occupational	Occupational	NNP
cord-006229-7yoilsho	3434	23	Safety	Safety	NNP
cord-006229-7yoilsho	3434	24	and	and	CC
cord-006229-7yoilsho	3434	25	Health	Health	NNP
cord-006229-7yoilsho	3434	26	,	,	,
cord-006229-7yoilsho	3434	27	German	German	NNP
cord-006229-7yoilsho	3434	28	Federal	Federal	NNP
cord-006229-7yoilsho	3434	29	Environment	Environment	NNP
cord-006229-7yoilsho	3434	30	Agency	Agency	NNP
cord-006229-7yoilsho	3434	31	funded	fund	VBD
cord-006229-7yoilsho	3434	32	this	this	DT
cord-006229-7yoilsho	3434	33	project	project	NN
cord-006229-7yoilsho	3434	34	.	.	.
cord-006229-7yoilsho	3435	1	Lung	lung	NN
cord-006229-7yoilsho	3435	2	carcinogenicity	carcinogenicity	NN
cord-006229-7yoilsho	3435	3	and	and	CC
cord-006229-7yoilsho	3435	4	putative	putative	JJ
cord-006229-7yoilsho	3435	5	systemic	systemic	JJ
cord-006229-7yoilsho	3435	6	effects	effect	NNS
cord-006229-7yoilsho	3435	7	of	of	IN
cord-006229-7yoilsho	3435	8	low	low	JJ
cord-006229-7yoilsho	3435	9	-	-	HYPH
cord-006229-7yoilsho	3435	10	dose	dose	NN
cord-006229-7yoilsho	3435	11	life	life	NN
cord-006229-7yoilsho	3435	12	-	-	HYPH
cord-006229-7yoilsho	3435	13	time	time	NN
cord-006229-7yoilsho	3435	14	inhalation	inhalation	NN
cord-006229-7yoilsho	3435	15	exposure	exposure	NN
cord-006229-7yoilsho	3435	16	to	to	IN
cord-006229-7yoilsho	3435	17	biopersistent	biopersistent	NN
cord-006229-7yoilsho	3435	18	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	3435	19	were	be	VBD
cord-006229-7yoilsho	3435	20	examined	examine	VBN
cord-006229-7yoilsho	3435	21	in	in	IN
cord-006229-7yoilsho	3435	22	a	a	DT
cord-006229-7yoilsho	3435	23	chronic	chronic	JJ
cord-006229-7yoilsho	3435	24	inhalation	inhalation	NN
cord-006229-7yoilsho	3435	25	study	study	NN
cord-006229-7yoilsho	3435	26	performed	perform	VBN
cord-006229-7yoilsho	3435	27	according	accord	VBG
cord-006229-7yoilsho	3435	28	to	to	IN
cord-006229-7yoilsho	3435	29	OECD	OECD	NNP
cord-006229-7yoilsho	3435	30	test	test	NN
cord-006229-7yoilsho	3435	31	guideline	guideline	NN
cord-006229-7yoilsho	3435	32	no	no	NN
cord-006229-7yoilsho	3435	33	.	.	.
cord-006229-7yoilsho	3436	1	453	453	CD
cord-006229-7yoilsho	3436	2	with	with	IN
cord-006229-7yoilsho	3436	3	several	several	JJ
cord-006229-7yoilsho	3436	4	protocol	protocol	NN
cord-006229-7yoilsho	3436	5	extensions	extension	NNS
cord-006229-7yoilsho	3436	6	.	.	.
cord-006229-7yoilsho	3437	1	Female	female	JJ
cord-006229-7yoilsho	3437	2	rats	rat	NNS
cord-006229-7yoilsho	3437	3	(	(	-LRB-
cord-006229-7yoilsho	3437	4	100	100	CD
cord-006229-7yoilsho	3437	5	/	/	SYM
cord-006229-7yoilsho	3437	6	group	group	NN
cord-006229-7yoilsho	3437	7	)	)	-RRB-
cord-006229-7yoilsho	3437	8	were	be	VBD
cord-006229-7yoilsho	3437	9	exposed	expose	VBN
cord-006229-7yoilsho	3437	10	to	to	IN
cord-006229-7yoilsho	3437	11	cerium	cerium	NN
cord-006229-7yoilsho	3437	12	dioxide	dioxide	NN
cord-006229-7yoilsho	3437	13	(	(	-LRB-
cord-006229-7yoilsho	3437	14	NM-212	NM-212	NNP
cord-006229-7yoilsho	3437	15	,	,	,
cord-006229-7yoilsho	3437	16	0.1	0.1	CD
cord-006229-7yoilsho	3437	17	;	;	:
cord-006229-7yoilsho	3437	18	0.3	0.3	CD
cord-006229-7yoilsho	3437	19	;	;	:
cord-006229-7yoilsho	3437	20	1	1	CD
cord-006229-7yoilsho	3437	21	;	;	:
cord-006229-7yoilsho	3437	22	3	3	CD
cord-006229-7yoilsho	3437	23	mg	mg	NN
cord-006229-7yoilsho	3437	24	/	/	SYM
cord-006229-7yoilsho	3437	25	m³	m³	NN
cord-006229-7yoilsho	3437	26	)	)	-RRB-
cord-006229-7yoilsho	3437	27	and	and	CC
cord-006229-7yoilsho	3437	28	barium	barium	NN
cord-006229-7yoilsho	3437	29	sulfate	sulfate	NN
cord-006229-7yoilsho	3437	30	(	(	-LRB-
cord-006229-7yoilsho	3438	1	NM-220	NM-220	NNP
cord-006229-7yoilsho	3438	2	;	;	:
cord-006229-7yoilsho	3438	3	50	50	CD
cord-006229-7yoilsho	3438	4	mg	mg	NNP
cord-006229-7yoilsho	3438	5	/	/	SYM
cord-006229-7yoilsho	3438	6	m³	m³	NN
cord-006229-7yoilsho	3438	7	)	)	-RRB-
cord-006229-7yoilsho	3438	8	for	for	IN
cord-006229-7yoilsho	3438	9	two	two	CD
cord-006229-7yoilsho	3438	10	years	year	NNS
cord-006229-7yoilsho	3438	11	;	;	:
cord-006229-7yoilsho	3438	12	a	a	DT
cord-006229-7yoilsho	3438	13	control	control	NN
cord-006229-7yoilsho	3438	14	group	group	NN
cord-006229-7yoilsho	3438	15	was	be	VBD
cord-006229-7yoilsho	3438	16	exposed	expose	VBN
cord-006229-7yoilsho	3438	17	to	to	TO
cord-006229-7yoilsho	3438	18	clean	clean	JJ
cord-006229-7yoilsho	3438	19	air	air	NN
cord-006229-7yoilsho	3438	20	.	.	.
cord-006229-7yoilsho	3439	1	Lung	lung	NN
cord-006229-7yoilsho	3439	2	burdens	burden	NNS
cord-006229-7yoilsho	3439	3	and	and	CC
cord-006229-7yoilsho	3439	4	burdens	burden	NNS
cord-006229-7yoilsho	3439	5	in	in	IN
cord-006229-7yoilsho	3439	6	extrahepatic	extrahepatic	JJ
cord-006229-7yoilsho	3439	7	tissues	tissue	NNS
cord-006229-7yoilsho	3439	8	were	be	VBD
cord-006229-7yoilsho	3439	9	measured	measure	VBN
cord-006229-7yoilsho	3439	10	at	at	IN
cord-006229-7yoilsho	3439	11	various	various	JJ
cord-006229-7yoilsho	3439	12	time	time	NN
cord-006229-7yoilsho	3439	13	-	-	HYPH
cord-006229-7yoilsho	3439	14	point	point	NN
cord-006229-7yoilsho	3439	15	.	.	.
cord-006229-7yoilsho	3440	1	The	the	DT
cord-006229-7yoilsho	3440	2	two	two	CD
cord-006229-7yoilsho	3440	3	year	year	NN
cord-006229-7yoilsho	3440	4	exposure	exposure	NN
cord-006229-7yoilsho	3440	5	period	period	NN
cord-006229-7yoilsho	3440	6	was	be	VBD
cord-006229-7yoilsho	3440	7	successfully	successfully	RB
cord-006229-7yoilsho	3440	8	terminated	terminate	VBN
cord-006229-7yoilsho	3440	9	and	and	CC
cord-006229-7yoilsho	3440	10	50	50	CD
cord-006229-7yoilsho	3440	11	animals	animal	NNS
cord-006229-7yoilsho	3440	12	per	per	IN
cord-006229-7yoilsho	3440	13	dose	dose	NN
cord-006229-7yoilsho	3440	14	group	group	NN
cord-006229-7yoilsho	3440	15	were	be	VBD
cord-006229-7yoilsho	3440	16	examined	examine	VBN
cord-006229-7yoilsho	3440	17	for	for	IN
cord-006229-7yoilsho	3440	18	organ	organ	NN
cord-006229-7yoilsho	3440	19	burden	burden	NN
cord-006229-7yoilsho	3440	20	and	and	CC
cord-006229-7yoilsho	3440	21	histopathology	histopathology	NN
cord-006229-7yoilsho	3440	22	.	.	.
cord-006229-7yoilsho	3441	1	The	the	DT
cord-006229-7yoilsho	3441	2	remaining	remain	VBG
cord-006229-7yoilsho	3441	3	animals	animal	NNS
cord-006229-7yoilsho	3441	4	currently	currently	RB
cord-006229-7yoilsho	3441	5	are	be	VBP
cord-006229-7yoilsho	3441	6	kept	keep	VBN
cord-006229-7yoilsho	3441	7	exposure	exposure	NN
cord-006229-7yoilsho	3441	8	-	-	HYPH
cord-006229-7yoilsho	3441	9	free	free	JJ
cord-006229-7yoilsho	3441	10	for	for	IN
cord-006229-7yoilsho	3441	11	maximally	maximally	RB
cord-006229-7yoilsho	3441	12	6	6	CD
cord-006229-7yoilsho	3441	13	additional	additional	JJ
cord-006229-7yoilsho	3441	14	months	month	NNS
cord-006229-7yoilsho	3441	15	.	.	.
cord-006229-7yoilsho	3442	1	Up	up	IN
cord-006229-7yoilsho	3442	2	to	to	TO
cord-006229-7yoilsho	3442	3	two	two	CD
cord-006229-7yoilsho	3442	4	years	year	NNS
cord-006229-7yoilsho	3442	5	exposure	exposure	NN
cord-006229-7yoilsho	3442	6	to	to	IN
cord-006229-7yoilsho	3442	7	both	both	DT
cord-006229-7yoilsho	3442	8	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	3442	9	did	do	VBD
cord-006229-7yoilsho	3442	10	not	not	RB
cord-006229-7yoilsho	3442	11	lead	lead	VB
cord-006229-7yoilsho	3442	12	to	to	IN
cord-006229-7yoilsho	3442	13	body	body	NN
cord-006229-7yoilsho	3442	14	weight	weight	NN
cord-006229-7yoilsho	3442	15	reduction	reduction	NN
cord-006229-7yoilsho	3442	16	compared	compare	VBN
cord-006229-7yoilsho	3442	17	to	to	TO
cord-006229-7yoilsho	3442	18	control	control	NN
cord-006229-7yoilsho	3442	19	animals	animal	NNS
cord-006229-7yoilsho	3442	20	.	.	.
cord-006229-7yoilsho	3443	1	The	the	DT
cord-006229-7yoilsho	3443	2	mortality	mortality	NN
cord-006229-7yoilsho	3443	3	rates	rate	NNS
cord-006229-7yoilsho	3443	4	were	be	VBD
cord-006229-7yoilsho	3443	5	in	in	IN
cord-006229-7yoilsho	3443	6	an	an	DT
cord-006229-7yoilsho	3443	7	acceptable	acceptable	JJ
cord-006229-7yoilsho	3443	8	range	range	NN
cord-006229-7yoilsho	3443	9	.	.	.
cord-006229-7yoilsho	3444	1	Macroscopically	macroscopically	RB
cord-006229-7yoilsho	3444	2	evident	evident	JJ
cord-006229-7yoilsho	3444	3	tumors	tumor	NNS
cord-006229-7yoilsho	3444	4	were	be	VBD
cord-006229-7yoilsho	3444	5	not	not	RB
cord-006229-7yoilsho	3444	6	detected	detect	VBN
cord-006229-7yoilsho	3444	7	after	after	IN
cord-006229-7yoilsho	3444	8	two	two	CD
cord-006229-7yoilsho	3444	9	years	year	NNS
cord-006229-7yoilsho	3444	10	.	.	.
cord-006229-7yoilsho	3445	1	The	the	DT
cord-006229-7yoilsho	3445	2	CeO	ceo	NN
cord-006229-7yoilsho	3445	3	2	2	CD
cord-006229-7yoilsho	3445	4	lung	lung	NN
cord-006229-7yoilsho	3445	5	burdens	burden	NNS
cord-006229-7yoilsho	3445	6	were	be	VBD
cord-006229-7yoilsho	3445	7	maximally	maximally	RB
cord-006229-7yoilsho	3445	8	3.5	3.5	CD
cord-006229-7yoilsho	3445	9	mg	mg	NNP
cord-006229-7yoilsho	3445	10	/	/	SYM
cord-006229-7yoilsho	3445	11	g	g	NN
cord-006229-7yoilsho	3445	12	lung	lung	NN
cord-006229-7yoilsho	3445	13	tissue	tissue	NN
cord-006229-7yoilsho	3445	14	at	at	IN
cord-006229-7yoilsho	3445	15	the	the	DT
cord-006229-7yoilsho	3445	16	highest	high	JJS
cord-006229-7yoilsho	3445	17	exposure	exposure	NN
cord-006229-7yoilsho	3445	18	concentration	concentration	NN
cord-006229-7yoilsho	3445	19	of	of	IN
cord-006229-7yoilsho	3445	20	3	3	CD
cord-006229-7yoilsho	3445	21	mg	mg	NNP
cord-006229-7yoilsho	3445	22	/	/	SYM
cord-006229-7yoilsho	3445	23	m³.	m³.	VBZ
cord-006229-7yoilsho	3446	1	In	in	IN
cord-006229-7yoilsho	3446	2	comparison	comparison	NN
cord-006229-7yoilsho	3446	3	,	,	,
cord-006229-7yoilsho	3446	4	highest	high	JJS
cord-006229-7yoilsho	3446	5	CeO	ceo	NN
cord-006229-7yoilsho	3446	6	2	2	CD
cord-006229-7yoilsho	3446	7	burdens	burden	NNS
cord-006229-7yoilsho	3446	8	in	in	IN
cord-006229-7yoilsho	3446	9	organs	organ	NNS
cord-006229-7yoilsho	3446	10	remote	remote	JJ
cord-006229-7yoilsho	3446	11	to	to	IN
cord-006229-7yoilsho	3446	12	exposure	exposure	NN
cord-006229-7yoilsho	3446	13	were	be	VBD
cord-006229-7yoilsho	3446	14	liver	liver	NN
cord-006229-7yoilsho	3446	15	and	and	CC
cord-006229-7yoilsho	3446	16	spleen	spleen	NNS
cord-006229-7yoilsho	3446	17	with	with	IN
cord-006229-7yoilsho	3446	18	maximally	maximally	RB
cord-006229-7yoilsho	3446	19	roughly	roughly	RB
cord-006229-7yoilsho	3446	20	1	1	CD
cord-006229-7yoilsho	3446	21	x	x	SYM
cord-006229-7yoilsho	3446	22	10	10	CD
cord-006229-7yoilsho	3446	23	-3	-3	NNP
cord-006229-7yoilsho	3446	24	g	g	NN
cord-006229-7yoilsho	3446	25	/	/	SYM
cord-006229-7yoilsho	3446	26	g	g	NN
cord-006229-7yoilsho	3446	27	tissue	tissue	NN
cord-006229-7yoilsho	3446	28	.	.	.
cord-006229-7yoilsho	3447	1	In	in	IN
cord-006229-7yoilsho	3447	2	brain	brain	NN
cord-006229-7yoilsho	3447	3	,	,	,
cord-006229-7yoilsho	3447	4	maximum	maximum	JJ
cord-006229-7yoilsho	3447	5	CeO	ceo	NN
cord-006229-7yoilsho	3447	6	2	2	CD
cord-006229-7yoilsho	3447	7	levels	level	NNS
cord-006229-7yoilsho	3447	8	were	be	VBD
cord-006229-7yoilsho	3447	9	7x10	7x10	CD
cord-006229-7yoilsho	3447	10	-6	-6	.
cord-006229-7yoilsho	3448	1	mg	mg	NNP
cord-006229-7yoilsho	3448	2	/	/	SYM
cord-006229-7yoilsho	3448	3	g	g	NN
cord-006229-7yoilsho	3448	4	lung	lung	NN
cord-006229-7yoilsho	3448	5	tissue	tissue	NN
cord-006229-7yoilsho	3448	6	.	.	.
cord-006229-7yoilsho	3449	1	BaSO	BaSO	NNP
cord-006229-7yoilsho	3449	2	4	4	CD
cord-006229-7yoilsho	3449	3	lung	lung	NN
cord-006229-7yoilsho	3449	4	burdens	burden	NNS
cord-006229-7yoilsho	3449	5	were	be	VBD
cord-006229-7yoilsho	3449	6	comparatively	comparatively	RB
cord-006229-7yoilsho	3449	7	low	low	JJ
cord-006229-7yoilsho	3449	8	(	(	-LRB-
cord-006229-7yoilsho	3449	9	1	1	CD
cord-006229-7yoilsho	3449	10	mg	mg	NNP
cord-006229-7yoilsho	3449	11	/	/	SYM
cord-006229-7yoilsho	3449	12	g	g	NNP
cord-006229-7yoilsho	3449	13	)	)	-RRB-
cord-006229-7yoilsho	3449	14	within	within	IN
cord-006229-7yoilsho	3449	15	the	the	DT
cord-006229-7yoilsho	3449	16	first	first	JJ
cord-006229-7yoilsho	3449	17	13	13	CD
cord-006229-7yoilsho	3449	18	weeks	week	NNS
cord-006229-7yoilsho	3449	19	of	of	IN
cord-006229-7yoilsho	3449	20	exposure	exposure	NN
cord-006229-7yoilsho	3449	21	and	and	CC
cord-006229-7yoilsho	3449	22	steeply	steeply	RB
cord-006229-7yoilsho	3449	23	increased	increase	VBD
cord-006229-7yoilsho	3449	24	to	to	IN
cord-006229-7yoilsho	3449	25	6	6	CD
cord-006229-7yoilsho	3449	26	mg	mg	NN
cord-006229-7yoilsho	3449	27	/	/	SYM
cord-006229-7yoilsho	3449	28	g	g	NN
cord-006229-7yoilsho	3449	29	lung	lung	NN
cord-006229-7yoilsho	3449	30	tissue	tissue	NN
cord-006229-7yoilsho	3449	31	after	after	IN
cord-006229-7yoilsho	3449	32	one	one	CD
cord-006229-7yoilsho	3449	33	year	year	NN
cord-006229-7yoilsho	3449	34	.	.	.
cord-006229-7yoilsho	3450	1	The	the	DT
cord-006229-7yoilsho	3450	2	comprehensive	comprehensive	JJ
cord-006229-7yoilsho	3450	3	histopathological	histopathological	JJ
cord-006229-7yoilsho	3450	4	examinations	examination	NNS
cord-006229-7yoilsho	3450	5	of	of	IN
cord-006229-7yoilsho	3450	6	lungs	lung	NNS
cord-006229-7yoilsho	3450	7	and	and	CC
cord-006229-7yoilsho	3450	8	other	other	JJ
cord-006229-7yoilsho	3450	9	tissues	tissue	NNS
cord-006229-7yoilsho	3450	10	will	will	MD
cord-006229-7yoilsho	3450	11	be	be	VB
cord-006229-7yoilsho	3450	12	finalized	finalize	VBN
cord-006229-7yoilsho	3450	13	in	in	IN
cord-006229-7yoilsho	3450	14	2017	2017	CD
cord-006229-7yoilsho	3450	15	.	.	.
cord-006229-7yoilsho	3451	1	The	the	DT
cord-006229-7yoilsho	3451	2	European	European	NNP
cord-006229-7yoilsho	3451	3	Centre	Centre	NNP
cord-006229-7yoilsho	3451	4	for	for	IN
cord-006229-7yoilsho	3451	5	Ecotoxicology	Ecotoxicology	NNP
cord-006229-7yoilsho	3451	6	and	and	CC
cord-006229-7yoilsho	3451	7	Toxicology	Toxicology	NNP
cord-006229-7yoilsho	3451	8	of	of	IN
cord-006229-7yoilsho	3451	9	Chemicals	Chemicals	NNPS
cord-006229-7yoilsho	3451	10	(	(	-LRB-
cord-006229-7yoilsho	3451	11	ECETOC	ECETOC	NNP
cord-006229-7yoilsho	3451	12	)	)	-RRB-
cord-006229-7yoilsho	3451	13	'	'	''
cord-006229-7yoilsho	3452	1	Nano	Nano	NNP
cord-006229-7yoilsho	3452	2	Task	Task	NNP
cord-006229-7yoilsho	3452	3	Force	Force	NNP
cord-006229-7yoilsho	3452	4	'	'	''
cord-006229-7yoilsho	3452	5	proposes	propose	VBZ
cord-006229-7yoilsho	3452	6	Decision	decision	NN
cord-006229-7yoilsho	3452	7	-	-	HYPH
cord-006229-7yoilsho	3452	8	making	make	VBG
cord-006229-7yoilsho	3452	9	framework	framework	NN
cord-006229-7yoilsho	3452	10	for	for	IN
cord-006229-7yoilsho	3452	11	the	the	DT
cord-006229-7yoilsho	3452	12	grouping	grouping	NN
cord-006229-7yoilsho	3452	13	and	and	CC
cord-006229-7yoilsho	3452	14	testing	testing	NN
cord-006229-7yoilsho	3452	15	of	of	IN
cord-006229-7yoilsho	3452	16	nanomaterials	nanomaterial	NNS
cord-006229-7yoilsho	3452	17	(	(	-LRB-
cord-006229-7yoilsho	3452	18	DF4nano	DF4nano	NNP
cord-006229-7yoilsho	3452	19	)	)	-RRB-
cord-006229-7yoilsho	3452	20	that	that	WDT
cord-006229-7yoilsho	3452	21	consists	consist	VBZ
cord-006229-7yoilsho	3452	22	of	of	IN
cord-006229-7yoilsho	3452	23	3	3	CD
cord-006229-7yoilsho	3452	24	tiers	tier	NNS
cord-006229-7yoilsho	3452	25	to	to	TO
cord-006229-7yoilsho	3452	26	assign	assign	VB
cord-006229-7yoilsho	3452	27	nanomaterials	nanomaterial	NNS
cord-006229-7yoilsho	3452	28	to	to	IN
cord-006229-7yoilsho	3452	29	4	4	CD
cord-006229-7yoilsho	3452	30	main	main	JJ
cord-006229-7yoilsho	3452	31	groups	group	NNS
cord-006229-7yoilsho	3452	32	,	,	,
cord-006229-7yoilsho	3452	33	to	to	TO
cord-006229-7yoilsho	3452	34	perform	perform	VB
cord-006229-7yoilsho	3452	35	sub	sub	NN
cord-006229-7yoilsho	3452	36	-	-	JJ
cord-006229-7yoilsho	3452	37	grouping	grouping	NN
cord-006229-7yoilsho	3452	38	within	within	IN
cord-006229-7yoilsho	3452	39	the	the	DT
cord-006229-7yoilsho	3452	40	main	main	JJ
cord-006229-7yoilsho	3452	41	groups	group	NNS
cord-006229-7yoilsho	3452	42	and	and	CC
cord-006229-7yoilsho	3452	43	to	to	TO
cord-006229-7yoilsho	3452	44	determine	determine	VB
cord-006229-7yoilsho	3452	45	and	and	CC
cord-006229-7yoilsho	3452	46	refine	refine	VB
cord-006229-7yoilsho	3452	47	specific	specific	JJ
cord-006229-7yoilsho	3452	48	information	information	NN
cord-006229-7yoilsho	3452	49	needs	need	NNS
cord-006229-7yoilsho	3452	50	.	.	.
cord-006229-7yoilsho	3453	1	The	the	DT
cord-006229-7yoilsho	3453	2	DF4nanoGrouping	df4nanogrouping	NN
cord-006229-7yoilsho	3453	3	covers	cover	VBZ
cord-006229-7yoilsho	3453	4	all	all	DT
cord-006229-7yoilsho	3453	5	relevant	relevant	JJ
cord-006229-7yoilsho	3453	6	aspects	aspect	NNS
cord-006229-7yoilsho	3453	7	of	of	IN
cord-006229-7yoilsho	3453	8	a	a	DT
cord-006229-7yoilsho	3453	9	nanomaterial	nanomaterial	JJ
cord-006229-7yoilsho	3453	10	's	's	POS
cord-006229-7yoilsho	3453	11	life	life	NN
cord-006229-7yoilsho	3453	12	cycle	cycle	NN
cord-006229-7yoilsho	3453	13	and	and	CC
cord-006229-7yoilsho	3453	14	biological	biological	JJ
cord-006229-7yoilsho	3453	15	pathways	pathway	NNS
cord-006229-7yoilsho	3453	16	,	,	,
cord-006229-7yoilsho	3453	17	i.e.	i.e.	FW
cord-006229-7yoilsho	3453	18	intrinsic	intrinsic	JJ
cord-006229-7yoilsho	3453	19	material	material	NN
cord-006229-7yoilsho	3453	20	and	and	CC
cord-006229-7yoilsho	3453	21	systemdependent	systemdependent	NN
cord-006229-7yoilsho	3453	22	properties	property	NNS
cord-006229-7yoilsho	3453	23	,	,	,
cord-006229-7yoilsho	3453	24	biopersistence	biopersistence	NN
cord-006229-7yoilsho	3453	25	,	,	,
cord-006229-7yoilsho	3453	26	uptake	uptake	NN
cord-006229-7yoilsho	3453	27	and	and	CC
cord-006229-7yoilsho	3453	28	biodistribution	biodistribution	NN
cord-006229-7yoilsho	3453	29	,	,	,
cord-006229-7yoilsho	3453	30	cellular	cellular	JJ
cord-006229-7yoilsho	3453	31	and	and	CC
cord-006229-7yoilsho	3453	32	apical	apical	JJ
cord-006229-7yoilsho	3453	33	toxic	toxic	JJ
cord-006229-7yoilsho	3453	34	effects	effect	NNS
cord-006229-7yoilsho	3453	35	.	.	.
cord-006229-7yoilsho	3454	1	Use	use	VB
cord-006229-7yoilsho	3454	2	(	(	-LRB-
cord-006229-7yoilsho	3454	3	including	include	VBG
cord-006229-7yoilsho	3454	4	manufacture	manufacture	NN
cord-006229-7yoilsho	3454	5	)	)	-RRB-
cord-006229-7yoilsho	3454	6	,	,	,
cord-006229-7yoilsho	3454	7	release	release	NN
cord-006229-7yoilsho	3454	8	and	and	CC
cord-006229-7yoilsho	3454	9	route	route	NN
cord-006229-7yoilsho	3454	10	of	of	IN
cord-006229-7yoilsho	3454	11	exposure	exposure	NN
cord-006229-7yoilsho	3454	12	are	be	VBP
cord-006229-7yoilsho	3454	13	applied	apply	VBN
cord-006229-7yoilsho	3454	14	as	as	IN
cord-006229-7yoilsho	3454	15	'	'	``
cord-006229-7yoilsho	3454	16	qualifiers	qualifier	NNS
cord-006229-7yoilsho	3454	17	'	'	''
cord-006229-7yoilsho	3454	18	within	within	IN
cord-006229-7yoilsho	3454	19	the	the	DT
cord-006229-7yoilsho	3454	20	DF4nano	DF4nano	NNP
cord-006229-7yoilsho	3454	21	to	to	TO
cord-006229-7yoilsho	3454	22	determine	determine	VB
cord-006229-7yoilsho	3454	23	if	if	IN
cord-006229-7yoilsho	3454	24	,	,	,
cord-006229-7yoilsho	3454	25	e.g.	e.g.	IN
cord-006229-7yoilsho	3454	26	nanomaterials	nanomaterial	NNS
cord-006229-7yoilsho	3454	27	can	can	MD
cord-006229-7yoilsho	3454	28	not	not	RB
cord-006229-7yoilsho	3454	29	be	be	VB
cord-006229-7yoilsho	3454	30	released	release	VBN
cord-006229-7yoilsho	3454	31	from	from	IN
cord-006229-7yoilsho	3454	32	a	a	DT
cord-006229-7yoilsho	3454	33	product	product	NN
cord-006229-7yoilsho	3454	34	matrix	matrix	NN
cord-006229-7yoilsho	3454	35	,	,	,
cord-006229-7yoilsho	3454	36	which	which	WDT
cord-006229-7yoilsho	3454	37	may	may	MD
cord-006229-7yoilsho	3454	38	justify	justify	VB
cord-006229-7yoilsho	3454	39	the	the	DT
cord-006229-7yoilsho	3454	40	waiving	waiving	NN
cord-006229-7yoilsho	3454	41	of	of	IN
cord-006229-7yoilsho	3454	42	testing	testing	NN
cord-006229-7yoilsho	3454	43	.	.	.
cord-006229-7yoilsho	3455	1	The	the	DT
cord-006229-7yoilsho	3455	2	four	four	CD
cord-006229-7yoilsho	3455	3	main	main	JJ
cord-006229-7yoilsho	3455	4	groups	group	NNS
cord-006229-7yoilsho	3455	5	encompass	encompass	VBP
cord-006229-7yoilsho	3455	6	(	(	-LRB-
cord-006229-7yoilsho	3455	7	1	1	CD
cord-006229-7yoilsho	3455	8	)	)	-RRB-
cord-006229-7yoilsho	3455	9	soluble	soluble	JJ
cord-006229-7yoilsho	3455	10	nanomaterials	nanomaterial	NNS
cord-006229-7yoilsho	3455	11	,	,	,
cord-006229-7yoilsho	3455	12	(	(	-LRB-
cord-006229-7yoilsho	3455	13	2	2	LS
cord-006229-7yoilsho	3455	14	)	)	-RRB-
cord-006229-7yoilsho	3455	15	biopersistent	biopersistent	JJ
cord-006229-7yoilsho	3455	16	high	high	JJ
cord-006229-7yoilsho	3455	17	aspect	aspect	NN
cord-006229-7yoilsho	3455	18	ratio	ratio	NN
cord-006229-7yoilsho	3455	19	nanomaterials	nanomaterial	NNS
cord-006229-7yoilsho	3455	20	,	,	,
cord-006229-7yoilsho	3455	21	(	(	-LRB-
cord-006229-7yoilsho	3455	22	3	3	LS
cord-006229-7yoilsho	3455	23	)	)	-RRB-
cord-006229-7yoilsho	3455	24	passive	passive	JJ
cord-006229-7yoilsho	3455	25	nanomaterials	nanomaterial	NNS
cord-006229-7yoilsho	3455	26	,	,	,
cord-006229-7yoilsho	3455	27	and	and	CC
cord-006229-7yoilsho	3455	28	(	(	-LRB-
cord-006229-7yoilsho	3455	29	4	4	LS
cord-006229-7yoilsho	3455	30	)	)	-RRB-
cord-006229-7yoilsho	3455	31	active	active	JJ
cord-006229-7yoilsho	3455	32	nanomaterials	nanomaterial	NNS
cord-006229-7yoilsho	3455	33	.	.	.
cord-006229-7yoilsho	3456	1	The	the	DT
cord-006229-7yoilsho	3456	2	DF4nano	DF4nano	NNP
cord-006229-7yoilsho	3456	3	aims	aim	VBZ
cord-006229-7yoilsho	3456	4	to	to	TO
cord-006229-7yoilsho	3456	5	group	group	NN
cord-006229-7yoilsho	3456	6	nanomaterials	nanomaterial	NNS
cord-006229-7yoilsho	3456	7	by	by	IN
cord-006229-7yoilsho	3456	8	their	-PRON-	PRP$
cord-006229-7yoilsho	3456	9	specific	specific	JJ
cord-006229-7yoilsho	3456	10	mode	mode	NN
cord-006229-7yoilsho	3456	11	-	-	HYPH
cord-006229-7yoilsho	3456	12	of	of	IN
cord-006229-7yoilsho	3456	13	-	-	HYPH
cord-006229-7yoilsho	3456	14	action	action	NN
cord-006229-7yoilsho	3456	15	that	that	WDT
cord-006229-7yoilsho	3456	16	results	result	VBZ
cord-006229-7yoilsho	3456	17	in	in	IN
cord-006229-7yoilsho	3456	18	an	an	DT
cord-006229-7yoilsho	3456	19	apical	apical	JJ
cord-006229-7yoilsho	3456	20	toxic	toxic	JJ
cord-006229-7yoilsho	3456	21	effect	effect	NN
cord-006229-7yoilsho	3456	22	.	.	.
cord-006229-7yoilsho	3457	1	This	this	DT
cord-006229-7yoilsho	3457	2	is	be	VBZ
cord-006229-7yoilsho	3457	3	eventually	eventually	RB
cord-006229-7yoilsho	3457	4	directed	direct	VBN
cord-006229-7yoilsho	3457	5	by	by	IN
cord-006229-7yoilsho	3457	6	a	a	DT
cord-006229-7yoilsho	3457	7	nanomaterial	nanomaterial	JJ
cord-006229-7yoilsho	3457	8	's	's	POS
cord-006229-7yoilsho	3457	9	intrinsic	intrinsic	JJ
cord-006229-7yoilsho	3457	10	properties	property	NNS
cord-006229-7yoilsho	3457	11	.	.	.
cord-006229-7yoilsho	3458	1	However	however	RB
cord-006229-7yoilsho	3458	2	,	,	,
cord-006229-7yoilsho	3458	3	since	since	IN
cord-006229-7yoilsho	3458	4	the	the	DT
cord-006229-7yoilsho	3458	5	exact	exact	JJ
cord-006229-7yoilsho	3458	6	correlation	correlation	NN
cord-006229-7yoilsho	3458	7	of	of	IN
cord-006229-7yoilsho	3458	8	intrinsic	intrinsic	JJ
cord-006229-7yoilsho	3458	9	material	material	NN
cord-006229-7yoilsho	3458	10	properties	property	NNS
cord-006229-7yoilsho	3458	11	and	and	CC
cord-006229-7yoilsho	3458	12	apical	apical	JJ
cord-006229-7yoilsho	3458	13	toxic	toxic	JJ
cord-006229-7yoilsho	3458	14	effect	effect	NN
cord-006229-7yoilsho	3458	15	is	be	VBZ
cord-006229-7yoilsho	3458	16	not	not	RB
cord-006229-7yoilsho	3458	17	yet	yet	RB
cord-006229-7yoilsho	3458	18	established	establish	VBN
cord-006229-7yoilsho	3458	19	,	,	,
cord-006229-7yoilsho	3458	20	the	the	DT
cord-006229-7yoilsho	3458	21	DF4nano	DF4nano	NNP
cord-006229-7yoilsho	3458	22	uses	use	VBZ
cord-006229-7yoilsho	3458	23	the	the	DT
cord-006229-7yoilsho	3458	24	'	'	``
cord-006229-7yoilsho	3458	25	functionality	functionality	NN
cord-006229-7yoilsho	3458	26	'	'	''
cord-006229-7yoilsho	3458	27	of	of	IN
cord-006229-7yoilsho	3458	28	nanomaterials	nanomaterial	NNS
cord-006229-7yoilsho	3458	29	for	for	IN
cord-006229-7yoilsho	3458	30	grouping	group	VBG
cord-006229-7yoilsho	3458	31	rather	rather	RB
cord-006229-7yoilsho	3458	32	than	than	IN
cord-006229-7yoilsho	3458	33	relying	rely	VBG
cord-006229-7yoilsho	3458	34	on	on	IN
cord-006229-7yoilsho	3458	35	intrinsic	intrinsic	JJ
cord-006229-7yoilsho	3458	36	material	material	NN
cord-006229-7yoilsho	3458	37	properties	property	NNS
cord-006229-7yoilsho	3458	38	alone	alone	RB
cord-006229-7yoilsho	3458	39	.	.	.
cord-006229-7yoilsho	3459	1	Such	such	JJ
cord-006229-7yoilsho	3459	2	functionalities	functionality	NNS
cord-006229-7yoilsho	3459	3	include	include	VBP
cord-006229-7yoilsho	3459	4	system	system	NN
cord-006229-7yoilsho	3459	5	-	-	HYPH
cord-006229-7yoilsho	3459	6	dependent	dependent	JJ
cord-006229-7yoilsho	3459	7	material	material	NN
cord-006229-7yoilsho	3459	8	properties	property	NNS
cord-006229-7yoilsho	3459	9	(	(	-LRB-
cord-006229-7yoilsho	3459	10	such	such	JJ
cord-006229-7yoilsho	3459	11	as	as	IN
cord-006229-7yoilsho	3459	12	dissolution	dissolution	NN
cord-006229-7yoilsho	3459	13	rate	rate	NN
cord-006229-7yoilsho	3459	14	in	in	IN
cord-006229-7yoilsho	3459	15	biologically	biologically	RB
cord-006229-7yoilsho	3459	16	relevant	relevant	JJ
cord-006229-7yoilsho	3459	17	media	medium	NNS
cord-006229-7yoilsho	3459	18	)	)	-RRB-
cord-006229-7yoilsho	3459	19	,	,	,
cord-006229-7yoilsho	3459	20	bio	bio	JJ
cord-006229-7yoilsho	3459	21	-	-	JJ
cord-006229-7yoilsho	3459	22	physical	physical	JJ
cord-006229-7yoilsho	3459	23	interactions	interaction	NNS
cord-006229-7yoilsho	3459	24	,	,	,
cord-006229-7yoilsho	3459	25	in	in	IN
cord-006229-7yoilsho	3459	26	vitro	vitro	FW
cord-006229-7yoilsho	3459	27	effects	effect	NNS
cord-006229-7yoilsho	3459	28	and	and	CC
cord-006229-7yoilsho	3459	29	release	release	NN
cord-006229-7yoilsho	3459	30	and	and	CC
cord-006229-7yoilsho	3459	31	exposure	exposure	NN
cord-006229-7yoilsho	3459	32	.	.	.
cord-006229-7yoilsho	3460	1	The	the	DT
cord-006229-7yoilsho	3460	2	DF4nano	DF4nano	NNP
cord-006229-7yoilsho	3460	3	is	be	VBZ
cord-006229-7yoilsho	3460	4	a	a	DT
cord-006229-7yoilsho	3460	5	hazard	hazard	NN
cord-006229-7yoilsho	3460	6	and	and	CC
cord-006229-7yoilsho	3460	7	risk	risk	NN
cord-006229-7yoilsho	3460	8	assessment	assessment	NN
cord-006229-7yoilsho	3460	9	tool	tool	NN
cord-006229-7yoilsho	3460	10	that	that	WDT
cord-006229-7yoilsho	3460	11	applies	apply	VBZ
cord-006229-7yoilsho	3460	12	modern	modern	JJ
cord-006229-7yoilsho	3460	13	toxicology	toxicology	NN
cord-006229-7yoilsho	3460	14	and	and	CC
cord-006229-7yoilsho	3460	15	contributes	contribute	VBZ
cord-006229-7yoilsho	3460	16	to	to	IN
cord-006229-7yoilsho	3460	17	the	the	DT
cord-006229-7yoilsho	3460	18	sustainable	sustainable	JJ
cord-006229-7yoilsho	3460	19	development	development	NN
cord-006229-7yoilsho	3460	20	of	of	IN
cord-006229-7yoilsho	3460	21	nano	nano	JJ
cord-006229-7yoilsho	3460	22	-	-	HYPH
cord-006229-7yoilsho	3460	23	technological	technological	JJ
cord-006229-7yoilsho	3460	24	products	product	NNS
cord-006229-7yoilsho	3460	25	.	.	.
cord-006229-7yoilsho	3461	1	It	-PRON-	PRP
cord-006229-7yoilsho	3461	2	ensures	ensure	VBZ
cord-006229-7yoilsho	3461	3	that	that	IN
cord-006229-7yoilsho	3461	4	no	no	DT
cord-006229-7yoilsho	3461	5	studies	study	NNS
cord-006229-7yoilsho	3461	6	are	be	VBP
cord-006229-7yoilsho	3461	7	performed	perform	VBN
cord-006229-7yoilsho	3461	8	that	that	WDT
cord-006229-7yoilsho	3461	9	do	do	VBP
cord-006229-7yoilsho	3461	10	not	not	RB
cord-006229-7yoilsho	3461	11	provide	provide	VB
cord-006229-7yoilsho	3461	12	crucial	crucial	JJ
cord-006229-7yoilsho	3461	13	data	datum	NNS
cord-006229-7yoilsho	3461	14	and	and	CC
cord-006229-7yoilsho	3461	15	therefore	therefore	RB
cord-006229-7yoilsho	3461	16	saves	save	VBZ
cord-006229-7yoilsho	3461	17	animals	animal	NNS
cord-006229-7yoilsho	3461	18	and	and	CC
cord-006229-7yoilsho	3461	19	resources	resource	NNS
cord-006229-7yoilsho	3461	20	.	.	.
cord-006229-7yoilsho	3462	1	The	the	DT
cord-006229-7yoilsho	3462	2	The	the	DT
cord-006229-7yoilsho	3462	3	grouping	grouping	NN
cord-006229-7yoilsho	3462	4	decisions	decision	NNS
cord-006229-7yoilsho	3462	5	of	of	IN
cord-006229-7yoilsho	3462	6	DF4nano	DF4nano	NNP
cord-006229-7yoilsho	3462	7	for	for	IN
cord-006229-7yoilsho	3462	8	24	24	CD
cord-006229-7yoilsho	3462	9	nanomaterials	nanomaterial	NNS
cord-006229-7yoilsho	3462	10	were	be	VBD
cord-006229-7yoilsho	3462	11	validated	validate	VBN
cord-006229-7yoilsho	3462	12	against	against	IN
cord-006229-7yoilsho	3462	13	grouping	grouping	NN
cord-006229-7yoilsho	3462	14	by	by	IN
cord-006229-7yoilsho	3462	15	results	result	NNS
cord-006229-7yoilsho	3462	16	of	of	IN
cord-006229-7yoilsho	3462	17	existing	exist	VBG
cord-006229-7yoilsho	3462	18	in	in	IN
cord-006229-7yoilsho	3462	19	vivo	vivo	NNP
cord-006229-7yoilsho	3462	20	data	datum	NNS
cord-006229-7yoilsho	3462	21	and	and	CC
cord-006229-7yoilsho	3462	22	demonstrated	demonstrate	VBD
cord-006229-7yoilsho	3462	23	23	23	CD
cord-006229-7yoilsho	3462	24	concordant	concordant	JJ
cord-006229-7yoilsho	3462	25	grouping	grouping	NN
cord-006229-7yoilsho	3462	26	decisions	decision	NNS
cord-006229-7yoilsho	3462	27	.	.	.
cord-006229-7yoilsho	3463	1	Serum	serum	NN
cord-006229-7yoilsho	3463	2	concentrations	concentration	NNS
cord-006229-7yoilsho	3463	3	in	in	IN
cord-006229-7yoilsho	3463	4	cell	cell	NN
cord-006229-7yoilsho	3463	5	culture	culture	NN
cord-006229-7yoilsho	3463	6	medium	medium	NN
cord-006229-7yoilsho	3463	7	influence	influence	VB
cord-006229-7yoilsho	3463	8	the	the	DT
cord-006229-7yoilsho	3463	9	effect	effect	NN
cord-006229-7yoilsho	3463	10	of	of	IN
cord-006229-7yoilsho	3463	11	cerium	cerium	NN
cord-006229-7yoilsho	3463	12	oxide	oxide	NN
cord-006229-7yoilsho	3463	13	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	3463	14	on	on	IN
cord-006229-7yoilsho	3463	15	human	human	JJ
cord-006229-7yoilsho	3463	16	lung	lung	NN
cord-006229-7yoilsho	3463	17	A549	A549	NNP
cord-006229-7yoilsho	3463	18	cells	cell	NNS
cord-006229-7yoilsho	3463	19	:	:	:
cord-006229-7yoilsho	3463	20	cytotoxicity	cytotoxicity	NN
cord-006229-7yoilsho	3463	21	,	,	,
cord-006229-7yoilsho	3463	22	proinflammation	proinflammation	NN
cord-006229-7yoilsho	3463	23	,	,	,
cord-006229-7yoilsho	3463	24	cellular	cellular	JJ
cord-006229-7yoilsho	3463	25	uptake	uptake	NN
cord-006229-7yoilsho	3463	26	,	,	,
cord-006229-7yoilsho	3463	27	and	and	CC
cord-006229-7yoilsho	3463	28	particle	particle	NN
cord-006229-7yoilsho	3463	29	properties	property	NNS
cord-006229-7yoilsho	3463	30	K.	K.	NNP
cord-006229-7yoilsho	3463	31	Burchardt	Burchardt	NNP
cord-006229-7yoilsho	3464	1	The	the	DT
cord-006229-7yoilsho	3464	2	wide	wide	JJ
cord-006229-7yoilsho	3464	3	use	use	NN
cord-006229-7yoilsho	3464	4	of	of	IN
cord-006229-7yoilsho	3464	5	cerium	cerium	NN
cord-006229-7yoilsho	3464	6	oxide	oxide	NN
cord-006229-7yoilsho	3464	7	(	(	-LRB-
cord-006229-7yoilsho	3464	8	CeO	CeO	NNP
cord-006229-7yoilsho	3464	9	2	2	CD
cord-006229-7yoilsho	3464	10	)	)	-RRB-
cord-006229-7yoilsho	3464	11	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	3464	12	(	(	-LRB-
cord-006229-7yoilsho	3464	13	NP	NP	NNP
cord-006229-7yoilsho	3464	14	)	)	-RRB-
cord-006229-7yoilsho	3464	15	,	,	,
cord-006229-7yoilsho	3464	16	e.g.	e.g.	RB
cord-006229-7yoilsho	3464	17	as	as	IN
cord-006229-7yoilsho	3464	18	fuel	fuel	NN
cord-006229-7yoilsho	3464	19	additive	additive	NN
cord-006229-7yoilsho	3464	20	and	and	CC
cord-006229-7yoilsho	3464	21	for	for	IN
cord-006229-7yoilsho	3464	22	industrial	industrial	JJ
cord-006229-7yoilsho	3464	23	and	and	CC
cord-006229-7yoilsho	3464	24	biomedical	biomedical	JJ
cord-006229-7yoilsho	3464	25	applications	application	NNS
cord-006229-7yoilsho	3464	26	,	,	,
cord-006229-7yoilsho	3464	27	evoked	evoke	VBD
cord-006229-7yoilsho	3464	28	intense	intense	JJ
cord-006229-7yoilsho	3464	29	studies	study	NNS
cord-006229-7yoilsho	3464	30	to	to	TO
cord-006229-7yoilsho	3464	31	understand	understand	VB
cord-006229-7yoilsho	3464	32	the	the	DT
cord-006229-7yoilsho	3464	33	effects	effect	NNS
cord-006229-7yoilsho	3464	34	those	those	DT
cord-006229-7yoilsho	3464	35	particles	particle	NNS
cord-006229-7yoilsho	3464	36	might	may	MD
cord-006229-7yoilsho	3464	37	have	have	VB
cord-006229-7yoilsho	3464	38	on	on	IN
cord-006229-7yoilsho	3464	39	living	live	VBG
cord-006229-7yoilsho	3464	40	organisms	organism	NNS
cord-006229-7yoilsho	3464	41	.	.	.
cord-006229-7yoilsho	3465	1	Contradictory	contradictory	JJ
cord-006229-7yoilsho	3465	2	results	result	NNS
cord-006229-7yoilsho	3465	3	of	of	IN
cord-006229-7yoilsho	3465	4	CeO	ceo	NN
cord-006229-7yoilsho	3465	5	2	2	CD
cord-006229-7yoilsho	3465	6	nanoparticle	nanoparticle	NN
cord-006229-7yoilsho	3465	7	toxicity	toxicity	NN
cord-006229-7yoilsho	3465	8	have	have	VBP
cord-006229-7yoilsho	3465	9	been	be	VBN
cord-006229-7yoilsho	3465	10	published	publish	VBN
cord-006229-7yoilsho	3465	11	as	as	IN
cord-006229-7yoilsho	3465	12	they	-PRON-	PRP
cord-006229-7yoilsho	3465	13	depend	depend	VBP
cord-006229-7yoilsho	3465	14	on	on	IN
cord-006229-7yoilsho	3465	15	many	many	JJ
cord-006229-7yoilsho	3465	16	variables	variable	NNS
cord-006229-7yoilsho	3465	17	like	like	IN
cord-006229-7yoilsho	3465	18	shape	shape	NN
cord-006229-7yoilsho	3465	19	,	,	,
cord-006229-7yoilsho	3465	20	size	size	NN
cord-006229-7yoilsho	3465	21	,	,	,
cord-006229-7yoilsho	3465	22	diluent	diluent	NN
cord-006229-7yoilsho	3465	23	and	and	CC
cord-006229-7yoilsho	3465	24	others	other	NNS
cord-006229-7yoilsho	3465	25	.	.	.
cord-006229-7yoilsho	3466	1	In	in	IN
cord-006229-7yoilsho	3466	2	our	-PRON-	PRP$
cord-006229-7yoilsho	3466	3	work	work	NN
cord-006229-7yoilsho	3466	4	we	-PRON-	PRP
cord-006229-7yoilsho	3466	5	used	use	VBD
cord-006229-7yoilsho	3466	6	an	an	DT
cord-006229-7yoilsho	3466	7	in	in	FW
cord-006229-7yoilsho	3466	8	vitro	vitro	FW
cord-006229-7yoilsho	3466	9	model	model	NN
cord-006229-7yoilsho	3466	10	of	of	IN
cord-006229-7yoilsho	3466	11	CeO	CeO	NNP
cord-006229-7yoilsho	3466	12	2	2	CD
cord-006229-7yoilsho	3466	13	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	3466	14	and	and	CC
cord-006229-7yoilsho	3466	15	lung	lung	NN
cord-006229-7yoilsho	3466	16	carcinoma	carcinoma	NN
cord-006229-7yoilsho	3466	17	cells	cell	NNS
cord-006229-7yoilsho	3466	18	to	to	TO
cord-006229-7yoilsho	3466	19	investigate	investigate	VB
cord-006229-7yoilsho	3466	20	the	the	DT
cord-006229-7yoilsho	3466	21	role	role	NN
cord-006229-7yoilsho	3466	22	of	of	IN
cord-006229-7yoilsho	3466	23	serum	serum	NN
cord-006229-7yoilsho	3466	24	content	content	NN
cord-006229-7yoilsho	3466	25	in	in	IN
cord-006229-7yoilsho	3466	26	the	the	DT
cord-006229-7yoilsho	3466	27	cell	cell	NN
cord-006229-7yoilsho	3466	28	culture	culture	NN
cord-006229-7yoilsho	3466	29	medium	medium	NN
cord-006229-7yoilsho	3466	30	on	on	IN
cord-006229-7yoilsho	3466	31	cellular	cellular	JJ
cord-006229-7yoilsho	3466	32	toxicity	toxicity	NN
cord-006229-7yoilsho	3466	33	,	,	,
cord-006229-7yoilsho	3466	34	particle	particle	NN
cord-006229-7yoilsho	3466	35	uptake	uptake	NN
cord-006229-7yoilsho	3466	36	,	,	,
cord-006229-7yoilsho	3466	37	proinflammation	proinflammation	NN
cord-006229-7yoilsho	3466	38	and	and	CC
cord-006229-7yoilsho	3466	39	particle	particle	NN
cord-006229-7yoilsho	3466	40	characteristics	characteristic	NNS
cord-006229-7yoilsho	3466	41	.	.	.
cord-006229-7yoilsho	3467	1	Proinflammatory	Proinflammatory	NNP
cord-006229-7yoilsho	3467	2	CeO	ceo	NN
cord-006229-7yoilsho	3467	3	2	2	CD
cord-006229-7yoilsho	3467	4	NP	NP	NNP
cord-006229-7yoilsho	3467	5	with	with	IN
cord-006229-7yoilsho	3467	6	an	an	DT
cord-006229-7yoilsho	3467	7	average	average	JJ
cord-006229-7yoilsho	3467	8	diameter	diameter	NN
cord-006229-7yoilsho	3467	9	of	of	IN
cord-006229-7yoilsho	3467	10	15	15	CD
cord-006229-7yoilsho	3467	11	-	-	SYM
cord-006229-7yoilsho	3467	12	30	30	CD
cord-006229-7yoilsho	3467	13	nm	nm	NN
cord-006229-7yoilsho	3467	14	and	and	CC
cord-006229-7yoilsho	3467	15	different	different	JJ
cord-006229-7yoilsho	3467	16	concentrations	concentration	NNS
cord-006229-7yoilsho	3467	17	were	be	VBD
cord-006229-7yoilsho	3467	18	diluted	dilute	VBN
cord-006229-7yoilsho	3467	19	in	in	IN
cord-006229-7yoilsho	3467	20	cell	cell	NN
cord-006229-7yoilsho	3467	21	culture	culture	NN
cord-006229-7yoilsho	3467	22	medium	medium	NN
cord-006229-7yoilsho	3467	23	with	with	IN
cord-006229-7yoilsho	3467	24	different	different	JJ
cord-006229-7yoilsho	3467	25	fetal	fetal	JJ
cord-006229-7yoilsho	3467	26	calf	calf	NN
cord-006229-7yoilsho	3467	27	serum	serum	NN
cord-006229-7yoilsho	3467	28	(	(	-LRB-
cord-006229-7yoilsho	3467	29	FCS	FCS	NNP
cord-006229-7yoilsho	3467	30	)	)	-RRB-
cord-006229-7yoilsho	3467	31	concentrations	concentration	NNS
cord-006229-7yoilsho	3467	32	(	(	-LRB-
cord-006229-7yoilsho	3467	33	0.01	0.01	CD
cord-006229-7yoilsho	3467	34	,	,	,
cord-006229-7yoilsho	3467	35	0.1	0.1	CD
cord-006229-7yoilsho	3467	36	,	,	,
cord-006229-7yoilsho	3467	37	1	1	CD
cord-006229-7yoilsho	3467	38	and	and	CC
cord-006229-7yoilsho	3467	39	10	10	CD
cord-006229-7yoilsho	3467	40	%	%	NN
cord-006229-7yoilsho	3467	41	)	)	-RRB-
cord-006229-7yoilsho	3467	42	and	and	CC
cord-006229-7yoilsho	3467	43	were	be	VBD
cord-006229-7yoilsho	3467	44	used	use	VBN
cord-006229-7yoilsho	3467	45	to	to	TO
cord-006229-7yoilsho	3467	46	expose	expose	VB
cord-006229-7yoilsho	3467	47	human	human	JJ
cord-006229-7yoilsho	3467	48	lung	lung	NN
cord-006229-7yoilsho	3467	49	adenocarcinoma	adenocarcinoma	NN
cord-006229-7yoilsho	3467	50	cells	cell	NNS
cord-006229-7yoilsho	3467	51	(	(	-LRB-
cord-006229-7yoilsho	3467	52	A549	a549	UH
cord-006229-7yoilsho	3467	53	)	)	-RRB-
cord-006229-7yoilsho	3467	54	for	for	IN
cord-006229-7yoilsho	3467	55	up	up	IN
cord-006229-7yoilsho	3467	56	to	to	TO
cord-006229-7yoilsho	3467	57	24	24	CD
cord-006229-7yoilsho	3467	58	hours	hour	NNS
cord-006229-7yoilsho	3467	59	.	.	.
cord-006229-7yoilsho	3468	1	At	at	IN
cord-006229-7yoilsho	3468	2	100µg	100µg	NNP
cord-006229-7yoilsho	3468	3	/	/	SYM
cord-006229-7yoilsho	3468	4	ml	ml	NN
cord-006229-7yoilsho	3468	5	CeO	ceo	NN
cord-006229-7yoilsho	3468	6	2	2	CD
cord-006229-7yoilsho	3468	7	NP	NP	NNP
cord-006229-7yoilsho	3468	8	showed	show	VBD
cord-006229-7yoilsho	3468	9	little	little	JJ
cord-006229-7yoilsho	3468	10	to	to	IN
cord-006229-7yoilsho	3469	1	no	no	DT
cord-006229-7yoilsho	3469	2	toxic	toxic	JJ
cord-006229-7yoilsho	3469	3	effecton	effecton	JJ
cord-006229-7yoilsho	3469	4	growth	growth	NN
cord-006229-7yoilsho	3469	5	arrested	arrest	VBN
cord-006229-7yoilsho	3469	6	A549	a549	JJ
cord-006229-7yoilsho	3469	7	cells	cell	NNS
cord-006229-7yoilsho	3469	8	at	at	IN
cord-006229-7yoilsho	3469	9	FCS	FCS	NNP
cord-006229-7yoilsho	3469	10	concentrations	concentration	NNS
cord-006229-7yoilsho	3469	11	of	of	IN
cord-006229-7yoilsho	3469	12	1	1	CD
cord-006229-7yoilsho	3469	13	%	%	NN
cord-006229-7yoilsho	3469	14	or	or	CC
cord-006229-7yoilsho	3469	15	below	below	RB
cord-006229-7yoilsho	3469	16	,	,	,
cord-006229-7yoilsho	3469	17	but	but	CC
cord-006229-7yoilsho	3469	18	cell	cell	NN
cord-006229-7yoilsho	3469	19	viability	viability	NN
cord-006229-7yoilsho	3469	20	was	be	VBD
cord-006229-7yoilsho	3469	21	decreased	decrease	VBN
cord-006229-7yoilsho	3469	22	to	to	IN
cord-006229-7yoilsho	3469	23	about	about	IN
cord-006229-7yoilsho	3469	24	80	80	CD
cord-006229-7yoilsho	3469	25	%	%	NN
cord-006229-7yoilsho	3469	26	in	in	IN
cord-006229-7yoilsho	3469	27	proliferating	proliferate	VBG
cord-006229-7yoilsho	3469	28	cells	cell	NNS
cord-006229-7yoilsho	3469	29	in	in	IN
cord-006229-7yoilsho	3469	30	cultures	culture	NNS
cord-006229-7yoilsho	3469	31	with	with	IN
cord-006229-7yoilsho	3469	32	10	10	CD
cord-006229-7yoilsho	3469	33	%	%	NN
cord-006229-7yoilsho	3469	34	FCS	FCS	NNP
cord-006229-7yoilsho	3469	35	.	.	.
cord-006229-7yoilsho	3470	1	The	the	DT
cord-006229-7yoilsho	3470	2	proinflammatory	proinflammatory	JJ
cord-006229-7yoilsho	3470	3	effect	effect	NN
cord-006229-7yoilsho	3470	4	of	of	IN
cord-006229-7yoilsho	3470	5	CeO	ceo	NN
cord-006229-7yoilsho	3470	6	2	2	CD
cord-006229-7yoilsho	3470	7	NP	NP	NNP
cord-006229-7yoilsho	3470	8	was	be	VBD
cord-006229-7yoilsho	3470	9	investigated	investigate	VBN
cord-006229-7yoilsho	3470	10	through	through	IN
cord-006229-7yoilsho	3470	11	measurement	measurement	NN
cord-006229-7yoilsho	3470	12	of	of	IN
cord-006229-7yoilsho	3470	13	IL-8	IL-8	NNP
cord-006229-7yoilsho	3470	14	mRNA	mrna	NN
cord-006229-7yoilsho	3470	15	expression	expression	NN
cord-006229-7yoilsho	3470	16	after	after	IN
cord-006229-7yoilsho	3470	17	3	3	CD
cord-006229-7yoilsho	3470	18	hours	hour	NNS
cord-006229-7yoilsho	3470	19	and	and	CC
cord-006229-7yoilsho	3470	20	cellular	cellular	JJ
cord-006229-7yoilsho	3470	21	IL-8	il-8	NN
cord-006229-7yoilsho	3470	22	secretion	secretion	NN
cord-006229-7yoilsho	3470	23	after	after	IN
cord-006229-7yoilsho	3470	24	24	24	CD
cord-006229-7yoilsho	3470	25	hours	hour	NNS
cord-006229-7yoilsho	3470	26	.	.	.
cord-006229-7yoilsho	3471	1	The	the	DT
cord-006229-7yoilsho	3471	2	qRT	qRT	NNP
cord-006229-7yoilsho	3471	3	-	-	HYPH
cord-006229-7yoilsho	3471	4	PCR	PCR	NNP
cord-006229-7yoilsho	3471	5	showed	show	VBD
cord-006229-7yoilsho	3471	6	that	that	IN
cord-006229-7yoilsho	3471	7	the	the	DT
cord-006229-7yoilsho	3471	8	expression	expression	NN
cord-006229-7yoilsho	3471	9	of	of	IN
cord-006229-7yoilsho	3471	10	IL-8	IL-8	NNP
cord-006229-7yoilsho	3471	11	mRNA	mrna	NN
cord-006229-7yoilsho	3471	12	in	in	IN
cord-006229-7yoilsho	3471	13	cells	cell	NNS
cord-006229-7yoilsho	3471	14	treated	treat	VBN
cord-006229-7yoilsho	3471	15	with	with	IN
cord-006229-7yoilsho	3471	16	100	100	CD
cord-006229-7yoilsho	3471	17	µg	µg	NN
cord-006229-7yoilsho	3471	18	/	/	SYM
cord-006229-7yoilsho	3471	19	ml	ml	NN
cord-006229-7yoilsho	3471	20	CeO	ceo	NN
cord-006229-7yoilsho	3471	21	2	2	CD
cord-006229-7yoilsho	3471	22	NP	NP	NNP
cord-006229-7yoilsho	3471	23	in	in	IN
cord-006229-7yoilsho	3471	24	10	10	CD
cord-006229-7yoilsho	3471	25	%	%	NN
cord-006229-7yoilsho	3471	26	FCS	FCS	NNP
cord-006229-7yoilsho	3471	27	medium	medium	NN
cord-006229-7yoilsho	3471	28	was	be	VBD
cord-006229-7yoilsho	3471	29	three	three	CD
cord-006229-7yoilsho	3471	30	times	time	NNS
cord-006229-7yoilsho	3471	31	higher	high	JJR
cord-006229-7yoilsho	3471	32	than	than	IN
cord-006229-7yoilsho	3471	33	in	in	IN
cord-006229-7yoilsho	3471	34	cells	cell	NNS
cord-006229-7yoilsho	3471	35	treated	treat	VBN
cord-006229-7yoilsho	3471	36	with	with	IN
cord-006229-7yoilsho	3471	37	lower	low	JJR
cord-006229-7yoilsho	3471	38	FCS	FCS	NNP
cord-006229-7yoilsho	3471	39	concentrations	concentration	NNS
cord-006229-7yoilsho	3471	40	.	.	.
cord-006229-7yoilsho	3472	1	This	this	DT
cord-006229-7yoilsho	3472	2	finding	finding	NN
cord-006229-7yoilsho	3472	3	correlated	correlate	VBD
cord-006229-7yoilsho	3472	4	with	with	IN
cord-006229-7yoilsho	3472	5	the	the	DT
cord-006229-7yoilsho	3472	6	cellular	cellular	JJ
cord-006229-7yoilsho	3472	7	IL-8	il-8	NN
cord-006229-7yoilsho	3472	8	secretion	secretion	NN
cord-006229-7yoilsho	3472	9	,	,	,
cord-006229-7yoilsho	3472	10	which	which	WDT
cord-006229-7yoilsho	3472	11	showed	show	VBD
cord-006229-7yoilsho	3472	12	a	a	DT
cord-006229-7yoilsho	3472	13	stronger	strong	JJR
cord-006229-7yoilsho	3472	14	increase	increase	NN
cord-006229-7yoilsho	3472	15	by	by	IN
cord-006229-7yoilsho	3472	16	cells	cell	NNS
cord-006229-7yoilsho	3472	17	treated	treat	VBN
cord-006229-7yoilsho	3472	18	at	at	IN
cord-006229-7yoilsho	3472	19	10	10	CD
cord-006229-7yoilsho	3472	20	%	%	NN
cord-006229-7yoilsho	3472	21	FCS	FCS	NNP
cord-006229-7yoilsho	3472	22	.	.	.
cord-006229-7yoilsho	3473	1	Differences	difference	NNS
cord-006229-7yoilsho	3473	2	in	in	IN
cord-006229-7yoilsho	3473	3	cellular	cellular	JJ
cord-006229-7yoilsho	3473	4	uptake	uptake	NN
cord-006229-7yoilsho	3473	5	of	of	IN
cord-006229-7yoilsho	3473	6	CeO	CeO	NNP
cord-006229-7yoilsho	3473	7	2	2	CD
cord-006229-7yoilsho	3473	8	NP	NP	NNP
cord-006229-7yoilsho	3473	9	was	be	VBD
cord-006229-7yoilsho	3473	10	determined	determine	VBN
cord-006229-7yoilsho	3473	11	by	by	IN
cord-006229-7yoilsho	3473	12	fluorescence	fluorescence	NN
cord-006229-7yoilsho	3473	13	-	-	HYPH
cord-006229-7yoilsho	3473	14	activated	activate	VBN
cord-006229-7yoilsho	3473	15	cell	cell	NN
cord-006229-7yoilsho	3473	16	sorting	sorting	NN
cord-006229-7yoilsho	3473	17	(	(	-LRB-
cord-006229-7yoilsho	3473	18	FACS	FACS	NNP
cord-006229-7yoilsho	3473	19	)	)	-RRB-
cord-006229-7yoilsho	3473	20	after	after	IN
cord-006229-7yoilsho	3473	21	2	2	CD
cord-006229-7yoilsho	3473	22	and	and	CC
cord-006229-7yoilsho	3473	23	24	24	CD
cord-006229-7yoilsho	3473	24	hours	hour	NNS
cord-006229-7yoilsho	3473	25	of	of	IN
cord-006229-7yoilsho	3473	26	exposition	exposition	NN
cord-006229-7yoilsho	3473	27	.	.	.
cord-006229-7yoilsho	3474	1	After	after	IN
cord-006229-7yoilsho	3474	2	2	2	CD
cord-006229-7yoilsho	3474	3	hours	hour	NNS
cord-006229-7yoilsho	3474	4	,	,	,
cord-006229-7yoilsho	3474	5	the	the	DT
cord-006229-7yoilsho	3474	6	cells	cell	NNS
cord-006229-7yoilsho	3474	7	treated	treat	VBN
cord-006229-7yoilsho	3474	8	with	with	IN
cord-006229-7yoilsho	3474	9	CeO	CeO	NNP
cord-006229-7yoilsho	3474	10	2	2	CD
cord-006229-7yoilsho	3474	11	NP	NP	NNP
cord-006229-7yoilsho	3474	12	in	in	IN
cord-006229-7yoilsho	3474	13	10	10	CD
cord-006229-7yoilsho	3474	14	%	%	NN
cord-006229-7yoilsho	3474	15	FCS	FCS	NNP
cord-006229-7yoilsho	3474	16	medium	medium	NN
cord-006229-7yoilsho	3474	17	showed	show	VBD
cord-006229-7yoilsho	3474	18	a	a	DT
cord-006229-7yoilsho	3474	19	lower	low	JJR
cord-006229-7yoilsho	3474	20	mean	mean	NN
cord-006229-7yoilsho	3474	21	granularity	granularity	NN
cord-006229-7yoilsho	3474	22	(	(	-LRB-
cord-006229-7yoilsho	3474	23	∆GMean	∆GMean	NNP
cord-006229-7yoilsho	3474	24	)	)	-RRB-
cord-006229-7yoilsho	3474	25	as	as	IN
cord-006229-7yoilsho	3474	26	measure	measure	NN
cord-006229-7yoilsho	3474	27	for	for	IN
cord-006229-7yoilsho	3474	28	cellular	cellular	JJ
cord-006229-7yoilsho	3474	29	particle	particle	NN
cord-006229-7yoilsho	3474	30	uptake	uptake	NN
cord-006229-7yoilsho	3474	31	than	than	IN
cord-006229-7yoilsho	3474	32	those	those	DT
cord-006229-7yoilsho	3474	33	with	with	IN
cord-006229-7yoilsho	3474	34	less	less	JJR
cord-006229-7yoilsho	3474	35	FCS	FCS	NNP
cord-006229-7yoilsho	3474	36	in	in	IN
cord-006229-7yoilsho	3474	37	medium	medium	NN
cord-006229-7yoilsho	3474	38	.	.	.
cord-006229-7yoilsho	3475	1	After	after	IN
cord-006229-7yoilsho	3475	2	24	24	CD
cord-006229-7yoilsho	3475	3	hours	hour	NNS
cord-006229-7yoilsho	3475	4	all	all	DT
cord-006229-7yoilsho	3475	5	probes	probe	NNS
cord-006229-7yoilsho	3475	6	showed	show	VBD
cord-006229-7yoilsho	3475	7	about	about	IN
cord-006229-7yoilsho	3475	8	the	the	DT
cord-006229-7yoilsho	3475	9	same	same	JJ
cord-006229-7yoilsho	3475	10	granularity	granularity	NN
cord-006229-7yoilsho	3475	11	.	.	.
cord-006229-7yoilsho	3476	1	To	to	TO
cord-006229-7yoilsho	3476	2	examine	examine	VB
cord-006229-7yoilsho	3476	3	the	the	DT
cord-006229-7yoilsho	3476	4	effect	effect	NN
cord-006229-7yoilsho	3476	5	the	the	DT
cord-006229-7yoilsho	3476	6	FCS	FCS	NNP
cord-006229-7yoilsho	3476	7	concentrations	concentration	NNS
cord-006229-7yoilsho	3476	8	on	on	IN
cord-006229-7yoilsho	3476	9	CeO	ceo	NN
cord-006229-7yoilsho	3476	10	2	2	CD
cord-006229-7yoilsho	3476	11	NP	NP	NNP
cord-006229-7yoilsho	3476	12	characteristics	characteristic	NNS
cord-006229-7yoilsho	3476	13	in	in	IN
cord-006229-7yoilsho	3476	14	cell	cell	NN
cord-006229-7yoilsho	3476	15	cultures	culture	NNS
cord-006229-7yoilsho	3476	16	we	-PRON-	PRP
cord-006229-7yoilsho	3476	17	used	use	VBD
cord-006229-7yoilsho	3476	18	dynamic	dynamic	JJ
cord-006229-7yoilsho	3476	19	light	light	JJ
cord-006229-7yoilsho	3476	20	scattering	scattering	NN
cord-006229-7yoilsho	3476	21	(	(	-LRB-
cord-006229-7yoilsho	3476	22	DLS	DLS	NNP
cord-006229-7yoilsho	3476	23	)	)	-RRB-
cord-006229-7yoilsho	3476	24	and	and	CC
cord-006229-7yoilsho	3476	25	phase	phase	NN
cord-006229-7yoilsho	3476	26	contrast	contrast	NN
cord-006229-7yoilsho	3476	27	microscopy	microscopy	NNS
cord-006229-7yoilsho	3476	28	(	(	-LRB-
cord-006229-7yoilsho	3476	29	PCM	PCM	NNP
cord-006229-7yoilsho	3476	30	)	)	-RRB-
cord-006229-7yoilsho	3476	31	.	.	.
cord-006229-7yoilsho	3477	1	DLS	DLS	NNP
cord-006229-7yoilsho	3477	2	measurements	measurement	NNS
cord-006229-7yoilsho	3477	3	revealed	reveal	VBD
cord-006229-7yoilsho	3477	4	an	an	DT
cord-006229-7yoilsho	3477	5	increasing	increase	VBG
cord-006229-7yoilsho	3477	6	hydrodynamic	hydrodynamic	JJ
cord-006229-7yoilsho	3477	7	diameter	diameter	NN
cord-006229-7yoilsho	3477	8	of	of	IN
cord-006229-7yoilsho	3477	9	the	the	DT
cord-006229-7yoilsho	3477	10	particles	particle	NNS
cord-006229-7yoilsho	3477	11	with	with	IN
cord-006229-7yoilsho	3477	12	decreasing	decrease	VBG
cord-006229-7yoilsho	3477	13	FCS	FCS	NNP
cord-006229-7yoilsho	3477	14	concentrations	concentration	NNS
cord-006229-7yoilsho	3477	15	(	(	-LRB-
cord-006229-7yoilsho	3477	16	about	about	RB
cord-006229-7yoilsho	3477	17	1030	1030	CD
cord-006229-7yoilsho	3477	18	nm	nm	NN
cord-006229-7yoilsho	3477	19	(	(	-LRB-
cord-006229-7yoilsho	3477	20	10	10	CD
cord-006229-7yoilsho	3477	21	%	%	NN
cord-006229-7yoilsho	3477	22	FCS	FCS	NNP
cord-006229-7yoilsho	3477	23	)	)	-RRB-
cord-006229-7yoilsho	3477	24	to	to	IN
cord-006229-7yoilsho	3477	25	4090	4090	CD
cord-006229-7yoilsho	3477	26	nm	nm	NN
cord-006229-7yoilsho	3477	27	(	(	-LRB-
cord-006229-7yoilsho	3477	28	0.01	0.01	CD
cord-006229-7yoilsho	3477	29	%	%	NN
cord-006229-7yoilsho	3477	30	FCS	FCS	NNP
cord-006229-7yoilsho	3477	31	)	)	-RRB-
cord-006229-7yoilsho	3477	32	)	)	-RRB-
cord-006229-7yoilsho	3477	33	,	,	,
cord-006229-7yoilsho	3477	34	which	which	WDT
cord-006229-7yoilsho	3477	35	was	be	VBD
cord-006229-7yoilsho	3477	36	correlated	correlate	VBN
cord-006229-7yoilsho	3477	37	by	by	IN
cord-006229-7yoilsho	3477	38	an	an	DT
cord-006229-7yoilsho	3477	39	increasing	increase	VBG
cord-006229-7yoilsho	3477	40	particle	particle	NN
cord-006229-7yoilsho	3477	41	agglomeration	agglomeration	NN
cord-006229-7yoilsho	3477	42	shown	show	VBN
cord-006229-7yoilsho	3477	43	by	by	IN
cord-006229-7yoilsho	3477	44	PCM	PCM	NNP
cord-006229-7yoilsho	3477	45	.	.	.
cord-006229-7yoilsho	3478	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	3478	2	results	result	NNS
cord-006229-7yoilsho	3478	3	show	show	VBP
cord-006229-7yoilsho	3478	4	that	that	IN
cord-006229-7yoilsho	3478	5	the	the	DT
cord-006229-7yoilsho	3478	6	FCS	FCS	NNP
cord-006229-7yoilsho	3478	7	concentration	concentration	NN
cord-006229-7yoilsho	3478	8	in	in	IN
cord-006229-7yoilsho	3478	9	cell	cell	NN
cord-006229-7yoilsho	3478	10	culture	culture	NN
cord-006229-7yoilsho	3478	11	medium	medium	NN
cord-006229-7yoilsho	3478	12	has	have	VBZ
cord-006229-7yoilsho	3478	13	a	a	DT
cord-006229-7yoilsho	3478	14	direct	direct	JJ
cord-006229-7yoilsho	3478	15	or	or	CC
cord-006229-7yoilsho	3478	16	indirect	indirect	JJ
cord-006229-7yoilsho	3478	17	impact	impact	NN
cord-006229-7yoilsho	3478	18	on	on	IN
cord-006229-7yoilsho	3478	19	the	the	DT
cord-006229-7yoilsho	3478	20	cytotoxicity	cytotoxicity	NN
cord-006229-7yoilsho	3478	21	,	,	,
cord-006229-7yoilsho	3478	22	the	the	DT
cord-006229-7yoilsho	3478	23	proinflammatory	proinflammatory	JJ
cord-006229-7yoilsho	3478	24	effect	effect	NN
cord-006229-7yoilsho	3478	25	,	,	,
cord-006229-7yoilsho	3478	26	the	the	DT
cord-006229-7yoilsho	3478	27	FACS	FACS	NNP
cord-006229-7yoilsho	3478	28	parameter	parameter	NN
cord-006229-7yoilsho	3478	29	for	for	IN
cord-006229-7yoilsho	3478	30	cellular	cellular	JJ
cord-006229-7yoilsho	3478	31	particle	particle	NN
cord-006229-7yoilsho	3478	32	uptake	uptake	NN
cord-006229-7yoilsho	3478	33	as	as	RB
cord-006229-7yoilsho	3478	34	well	well	RB
cord-006229-7yoilsho	3478	35	as	as	IN
cord-006229-7yoilsho	3478	36	on	on	IN
cord-006229-7yoilsho	3478	37	particle	particle	NN
cord-006229-7yoilsho	3478	38	properties	property	NNS
cord-006229-7yoilsho	3478	39	,	,	,
cord-006229-7yoilsho	3478	40	which	which	WDT
cord-006229-7yoilsho	3478	41	should	should	MD
cord-006229-7yoilsho	3478	42	be	be	VB
cord-006229-7yoilsho	3478	43	taken	take	VBN
cord-006229-7yoilsho	3478	44	into	into	IN
cord-006229-7yoilsho	3478	45	account	account	NN
cord-006229-7yoilsho	3478	46	when	when	WRB
cord-006229-7yoilsho	3478	47	designing	design	VBG
cord-006229-7yoilsho	3478	48	,	,	,
cord-006229-7yoilsho	3478	49	performing	perform	VBG
cord-006229-7yoilsho	3478	50	and	and	CC
cord-006229-7yoilsho	3478	51	interpreting	interpret	VBG
cord-006229-7yoilsho	3478	52	in	in	IN
cord-006229-7yoilsho	3478	53	vitro	vitro	FW
cord-006229-7yoilsho	3478	54	experiments	experiment	NNS
cord-006229-7yoilsho	3478	55	to	to	TO
cord-006229-7yoilsho	3478	56	investigate	investigate	VB
cord-006229-7yoilsho	3478	57	the	the	DT
cord-006229-7yoilsho	3478	58	toxicity	toxicity	NN
cord-006229-7yoilsho	3478	59	of	of	IN
cord-006229-7yoilsho	3478	60	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	3478	61	.	.	.
cord-006229-7yoilsho	3479	1	Toxic	toxic	JJ
cord-006229-7yoilsho	3479	2	and	and	CC
cord-006229-7yoilsho	3479	3	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	3479	4	effects	effect	NNS
cord-006229-7yoilsho	3479	5	of	of	IN
cord-006229-7yoilsho	3479	6	shape	shape	NN
cord-006229-7yoilsho	3479	7	-	-	HYPH
cord-006229-7yoilsho	3479	8	engineered	engineer	VBN
cord-006229-7yoilsho	3479	9	titanium	titanium	NN
cord-006229-7yoilsho	3479	10	dioxide	dioxide	NN
cord-006229-7yoilsho	3479	11	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	3479	12	in	in	IN
cord-006229-7yoilsho	3479	13	NR8383	nr8383	RB
cord-006229-7yoilsho	3479	14	rat	rat	NN
cord-006229-7yoilsho	3479	15	alveolar	alveolar	NN
cord-006229-7yoilsho	3479	16	macrophages	macrophage	NNS
cord-006229-7yoilsho	3479	17	.	.	.
cord-006229-7yoilsho	3480	1	Knowledge	knowledge	NN
cord-006229-7yoilsho	3480	2	about	about	IN
cord-006229-7yoilsho	3480	3	the	the	DT
cord-006229-7yoilsho	3480	4	contrasting	contrast	VBG
cord-006229-7yoilsho	3480	5	toxicity	toxicity	NN
cord-006229-7yoilsho	3480	6	of	of	IN
cord-006229-7yoilsho	3480	7	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	3480	8	(	(	-LRB-
cord-006229-7yoilsho	3480	9	NP	NP	NNP
cord-006229-7yoilsho	3480	10	)	)	-RRB-
cord-006229-7yoilsho	3480	11	of	of	IN
cord-006229-7yoilsho	3480	12	different	different	JJ
cord-006229-7yoilsho	3480	13	chemical	chemical	NN
cord-006229-7yoilsho	3480	14	composition	composition	NN
cord-006229-7yoilsho	3480	15	has	have	VBZ
cord-006229-7yoilsho	3480	16	steadily	steadily	RB
cord-006229-7yoilsho	3480	17	increased	increase	VBN
cord-006229-7yoilsho	3480	18	over	over	IN
cord-006229-7yoilsho	3480	19	the	the	DT
cord-006229-7yoilsho	3480	20	past	past	JJ
cord-006229-7yoilsho	3480	21	decade	decade	NN
cord-006229-7yoilsho	3480	22	.	.	.
cord-006229-7yoilsho	3481	1	However	however	RB
cord-006229-7yoilsho	3481	2	,	,	,
cord-006229-7yoilsho	3481	3	available	available	JJ
cord-006229-7yoilsho	3481	4	literature	literature	NN
cord-006229-7yoilsho	3481	5	often	often	RB
cord-006229-7yoilsho	3481	6	reveals	reveal	VBZ
cord-006229-7yoilsho	3481	7	considerable	considerable	JJ
cord-006229-7yoilsho	3481	8	differences	difference	NNS
cord-006229-7yoilsho	3481	9	in	in	IN
cord-006229-7yoilsho	3481	10	effects	effect	NNS
cord-006229-7yoilsho	3481	11	within	within	IN
cord-006229-7yoilsho	3481	12	a	a	DT
cord-006229-7yoilsho	3481	13	specific	specific	JJ
cord-006229-7yoilsho	3481	14	type	type	NN
cord-006229-7yoilsho	3481	15	of	of	IN
cord-006229-7yoilsho	3481	16	nanomaterial	nanomaterial	NN
cord-006229-7yoilsho	3481	17	.	.	.
cord-006229-7yoilsho	3482	1	These	these	DT
cord-006229-7yoilsho	3482	2	contrasts	contrast	NNS
cord-006229-7yoilsho	3482	3	have	have	VBP
cord-006229-7yoilsho	3482	4	been	be	VBN
cord-006229-7yoilsho	3482	5	contributed	contribute	VBN
cord-006229-7yoilsho	3482	6	to	to	IN
cord-006229-7yoilsho	3482	7	different	different	JJ
cord-006229-7yoilsho	3482	8	handling	handling	NN
cord-006229-7yoilsho	3482	9	and	and	CC
cord-006229-7yoilsho	3482	10	testing	testing	NN
cord-006229-7yoilsho	3482	11	protocols	protocol	NNS
cord-006229-7yoilsho	3482	12	as	as	RB
cord-006229-7yoilsho	3482	13	well	well	RB
cord-006229-7yoilsho	3482	14	as	as	IN
cord-006229-7yoilsho	3482	15	to	to	TO
cord-006229-7yoilsho	3482	16	sample	sample	VB
cord-006229-7yoilsho	3482	17	-	-	HYPH
cord-006229-7yoilsho	3482	18	specific	specific	JJ
cord-006229-7yoilsho	3482	19	differences	difference	NNS
cord-006229-7yoilsho	3482	20	in	in	IN
cord-006229-7yoilsho	3482	21	physico	physico	NN
cord-006229-7yoilsho	3482	22	-	-	HYPH
cord-006229-7yoilsho	3482	23	chemical	chemical	NN
cord-006229-7yoilsho	3482	24	properties	property	NNS
cord-006229-7yoilsho	3482	25	of	of	IN
cord-006229-7yoilsho	3482	26	NP	NP	NNP
cord-006229-7yoilsho	3482	27	that	that	WDT
cord-006229-7yoilsho	3482	28	could	could	MD
cord-006229-7yoilsho	3482	29	affect	affect	VB
cord-006229-7yoilsho	3482	30	their	-PRON-	PRP$
cord-006229-7yoilsho	3482	31	mode	mode	NN
cord-006229-7yoilsho	3482	32	of	of	IN
cord-006229-7yoilsho	3482	33	interaction	interaction	NN
cord-006229-7yoilsho	3482	34	with	with	IN
cord-006229-7yoilsho	3482	35	cells	cell	NNS
cord-006229-7yoilsho	3482	36	.	.	.
cord-006229-7yoilsho	3483	1	Within	within	IN
cord-006229-7yoilsho	3483	2	the	the	DT
cord-006229-7yoilsho	3483	3	nanometrology	nanometrology	NN
cord-006229-7yoilsho	3483	4	project	project	NN
cord-006229-7yoilsho	3483	5	SETNanoMetro	setnanometro	NN
cord-006229-7yoilsho	3483	6	,	,	,
cord-006229-7yoilsho	3483	7	the	the	DT
cord-006229-7yoilsho	3483	8	highly	highly	RB
cord-006229-7yoilsho	3483	9	controlled	control	VBN
cord-006229-7yoilsho	3483	10	generation	generation	NN
cord-006229-7yoilsho	3483	11	and	and	CC
cord-006229-7yoilsho	3483	12	characterisation	characterisation	NN
cord-006229-7yoilsho	3483	13	of	of	IN
cord-006229-7yoilsho	3483	14	a	a	DT
cord-006229-7yoilsho	3483	15	large	large	JJ
cord-006229-7yoilsho	3483	16	set	set	NN
cord-006229-7yoilsho	3483	17	of	of	IN
cord-006229-7yoilsho	3483	18	shape	shape	NN
cord-006229-7yoilsho	3483	19	-	-	HYPH
cord-006229-7yoilsho	3483	20	engineered	engineer	VBN
cord-006229-7yoilsho	3483	21	TiO	tio	NN
cord-006229-7yoilsho	3483	22	2	2	CD
cord-006229-7yoilsho	3483	23	NP	NP	NNP
cord-006229-7yoilsho	3483	24	allows	allow	VBZ
cord-006229-7yoilsho	3483	25	us	-PRON-	PRP
cord-006229-7yoilsho	3483	26	to	to	TO
cord-006229-7yoilsho	3483	27	investigate	investigate	VB
cord-006229-7yoilsho	3483	28	the	the	DT
cord-006229-7yoilsho	3483	29	potential	potential	JJ
cord-006229-7yoilsho	3483	30	role	role	NN
cord-006229-7yoilsho	3483	31	of	of	IN
cord-006229-7yoilsho	3483	32	subtle	subtle	JJ
cord-006229-7yoilsho	3483	33	shape	shape	NN
cord-006229-7yoilsho	3483	34	-	-	HYPH
cord-006229-7yoilsho	3483	35	and	and	CC
cord-006229-7yoilsho	3483	36	surface	surface	NN
cord-006229-7yoilsho	3483	37	structure	structure	NN
cord-006229-7yoilsho	3483	38	changes	change	NNS
cord-006229-7yoilsho	3483	39	on	on	IN
cord-006229-7yoilsho	3483	40	NP	NP	NNP
cord-006229-7yoilsho	3483	41	toxicity	toxicity	NN
cord-006229-7yoilsho	3483	42	.	.	.
cord-006229-7yoilsho	3484	1	As	as	IN
cord-006229-7yoilsho	3484	2	inhalation	inhalation	NN
cord-006229-7yoilsho	3484	3	represents	represent	VBZ
cord-006229-7yoilsho	3484	4	the	the	DT
cord-006229-7yoilsho	3484	5	most	most	RBS
cord-006229-7yoilsho	3484	6	relevant	relevant	JJ
cord-006229-7yoilsho	3484	7	uptake	uptake	NN
cord-006229-7yoilsho	3484	8	route	route	NN
cord-006229-7yoilsho	3484	9	of	of	IN
cord-006229-7yoilsho	3484	10	NP	NP	NNP
cord-006229-7yoilsho	3484	11	,	,	,
cord-006229-7yoilsho	3484	12	the	the	DT
cord-006229-7yoilsho	3484	13	NR8383	nr8383	NN
cord-006229-7yoilsho	3484	14	rat	rat	NN
cord-006229-7yoilsho	3484	15	alveolar	alveolar	NN
cord-006229-7yoilsho	3484	16	macrophage	macrophage	NN
cord-006229-7yoilsho	3484	17	cell	cell	NN
cord-006229-7yoilsho	3484	18	line	line	NN
cord-006229-7yoilsho	3484	19	was	be	VBD
cord-006229-7yoilsho	3484	20	selected	select	VBN
cord-006229-7yoilsho	3484	21	for	for	IN
cord-006229-7yoilsho	3484	22	in	in	FW
cord-006229-7yoilsho	3484	23	vitro	vitro	FW
cord-006229-7yoilsho	3484	24	toxicological	toxicological	JJ
cord-006229-7yoilsho	3484	25	testing	testing	NN
cord-006229-7yoilsho	3484	26	.	.	.
cord-006229-7yoilsho	3485	1	Since	since	IN
cord-006229-7yoilsho	3485	2	oxidative	oxidative	JJ
cord-006229-7yoilsho	3485	3	stress	stress	NN
cord-006229-7yoilsho	3485	4	and	and	CC
cord-006229-7yoilsho	3485	5	inflammation	inflammation	NN
cord-006229-7yoilsho	3485	6	are	be	VBP
cord-006229-7yoilsho	3485	7	considered	consider	VBN
cord-006229-7yoilsho	3485	8	as	as	IN
cord-006229-7yoilsho	3485	9	key	key	JJ
cord-006229-7yoilsho	3485	10	biological	biological	JJ
cord-006229-7yoilsho	3485	11	pathways	pathway	NNS
cord-006229-7yoilsho	3485	12	in	in	IN
cord-006229-7yoilsho	3485	13	nanotoxicity	nanotoxicity	NN
cord-006229-7yoilsho	3485	14	,	,	,
cord-006229-7yoilsho	3485	15	we	-PRON-	PRP
cord-006229-7yoilsho	3485	16	evaluated	evaluate	VBD
cord-006229-7yoilsho	3485	17	the	the	DT
cord-006229-7yoilsho	3485	18	expression	expression	NN
cord-006229-7yoilsho	3485	19	of	of	IN
cord-006229-7yoilsho	3485	20	the	the	DT
cord-006229-7yoilsho	3485	21	oxidative	oxidative	JJ
cord-006229-7yoilsho	3485	22	stress	stress	NN
cord-006229-7yoilsho	3485	23	marker	marker	NN
cord-006229-7yoilsho	3485	24	genes	gene	NNS
cord-006229-7yoilsho	3485	25	heme	heme	VBP
cord-006229-7yoilsho	3485	26	oxygenase-1	oxygenase-1	NNP
cord-006229-7yoilsho	3485	27	(	(	-LRB-
cord-006229-7yoilsho	3485	28	HO-1	HO-1	NNP
cord-006229-7yoilsho	3485	29	)	)	-RRB-
cord-006229-7yoilsho	3485	30	and	and	CC
cord-006229-7yoilsho	3485	31	g	g	NN
cord-006229-7yoilsho	3485	32	-	-	HYPH
cord-006229-7yoilsho	3485	33	glutamylcysteine	glutamylcysteine	NN
cord-006229-7yoilsho	3485	34	synthetase	synthetase	NN
cord-006229-7yoilsho	3485	35	(	(	-LRB-
cord-006229-7yoilsho	3485	36	g	g	NNP
cord-006229-7yoilsho	3485	37	-	-	HYPH
cord-006229-7yoilsho	3485	38	GCS	GCS	NNP
cord-006229-7yoilsho	3485	39	)	)	-RRB-
cord-006229-7yoilsho	3485	40	as	as	RB
cord-006229-7yoilsho	3485	41	well	well	RB
cord-006229-7yoilsho	3485	42	as	as	IN
cord-006229-7yoilsho	3485	43	the	the	DT
cord-006229-7yoilsho	3485	44	pro	pro	JJ
cord-006229-7yoilsho	3485	45	-	-	JJ
cord-006229-7yoilsho	3485	46	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	3485	47	genes	gene	NNS
cord-006229-7yoilsho	3485	48	interleukin	interleukin	NN
cord-006229-7yoilsho	3485	49	(	(	-LRB-
cord-006229-7yoilsho	3485	50	IL)-1β	IL)-1β	NNP
cord-006229-7yoilsho	3485	51	,	,	,
cord-006229-7yoilsho	3485	52	IL-6	IL-6	NNP
cord-006229-7yoilsho	3485	53	,	,	,
cord-006229-7yoilsho	3485	54	IL-18	IL-18	NNP
cord-006229-7yoilsho	3485	55	and	and	CC
cord-006229-7yoilsho	3485	56	inducible	inducible	JJ
cord-006229-7yoilsho	3485	57	nitric	nitric	NN
cord-006229-7yoilsho	3485	58	oxide	oxide	NN
cord-006229-7yoilsho	3485	59	synthase	synthase	NN
cord-006229-7yoilsho	3485	60	(	(	-LRB-
cord-006229-7yoilsho	3485	61	iNOS	inos	NN
cord-006229-7yoilsho	3485	62	)	)	-RRB-
cord-006229-7yoilsho	3485	63	by	by	IN
cord-006229-7yoilsho	3485	64	qRT	qRT	NNP
cord-006229-7yoilsho	3485	65	-	-	HYPH
cord-006229-7yoilsho	3485	66	PCR	PCR	NNP
cord-006229-7yoilsho	3485	67	.	.	.
cord-006229-7yoilsho	3486	1	Protein	protein	NN
cord-006229-7yoilsho	3486	2	levels	level	NNS
cord-006229-7yoilsho	3486	3	of	of	IN
cord-006229-7yoilsho	3486	4	IL-1β	il-1β	NN
cord-006229-7yoilsho	3486	5	and	and	CC
cord-006229-7yoilsho	3486	6	tumour	tumour	NN
cord-006229-7yoilsho	3486	7	necrosis	necrosis	NN
cord-006229-7yoilsho	3486	8	factor	factor	NN
cord-006229-7yoilsho	3486	9	-	-	HYPH
cord-006229-7yoilsho	3486	10	α	α	NN
cord-006229-7yoilsho	3486	11	(	(	-LRB-
cord-006229-7yoilsho	3486	12	TNF	TNF	NNP
cord-006229-7yoilsho	3486	13	-	-	HYPH
cord-006229-7yoilsho	3486	14	α	α	NNP
cord-006229-7yoilsho	3486	15	)	)	-RRB-
cord-006229-7yoilsho	3486	16	were	be	VBD
cord-006229-7yoilsho	3486	17	measured	measure	VBN
cord-006229-7yoilsho	3486	18	by	by	IN
cord-006229-7yoilsho	3486	19	ELISA	ELISA	NNP
cord-006229-7yoilsho	3486	20	.	.	.
cord-006229-7yoilsho	3487	1	Cytotoxicity	cytotoxicity	NN
cord-006229-7yoilsho	3487	2	testing	testing	NN
cord-006229-7yoilsho	3487	3	of	of	IN
cord-006229-7yoilsho	3487	4	the	the	DT
cord-006229-7yoilsho	3487	5	TiO	tio	JJ
cord-006229-7yoilsho	3487	6	2	2	CD
cord-006229-7yoilsho	3487	7	NP	NP	NNP
cord-006229-7yoilsho	3487	8	by	by	IN
cord-006229-7yoilsho	3487	9	WST-1	WST-1	NNP
cord-006229-7yoilsho	3487	10	assay	assay	NN
cord-006229-7yoilsho	3487	11	overall	overall	RB
cord-006229-7yoilsho	3487	12	revealed	reveal	VBD
cord-006229-7yoilsho	3487	13	only	only	RB
cord-006229-7yoilsho	3487	14	minimal	minimal	JJ
cord-006229-7yoilsho	3487	15	toxicity	toxicity	NN
cord-006229-7yoilsho	3487	16	in	in	IN
cord-006229-7yoilsho	3487	17	comparison	comparison	NN
cord-006229-7yoilsho	3487	18	to	to	TO
cord-006229-7yoilsho	3487	19	SiO	SiO	NNP
cord-006229-7yoilsho	3487	20	2	2	CD
cord-006229-7yoilsho	3487	21	NP	NP	NNP
cord-006229-7yoilsho	3487	22	which	which	WDT
cord-006229-7yoilsho	3487	23	were	be	VBD
cord-006229-7yoilsho	3487	24	used	use	VBN
cord-006229-7yoilsho	3487	25	as	as	IN
cord-006229-7yoilsho	3487	26	reference	reference	NN
cord-006229-7yoilsho	3487	27	material	material	NN
cord-006229-7yoilsho	3487	28	.	.	.
cord-006229-7yoilsho	3488	1	HO-1	HO-1	NNP
cord-006229-7yoilsho	3489	1	and	and	CC
cord-006229-7yoilsho	3490	1	g	g	NNP
cord-006229-7yoilsho	3490	2	-	-	HYPH
cord-006229-7yoilsho	3490	3	GCS	GCS	NNP
cord-006229-7yoilsho	3490	4	mRNA	mrna	NN
cord-006229-7yoilsho	3490	5	analyses	analysis	NNS
cord-006229-7yoilsho	3490	6	indicated	indicate	VBD
cord-006229-7yoilsho	3490	7	that	that	IN
cord-006229-7yoilsho	3490	8	specific	specific	JJ
cord-006229-7yoilsho	3490	9	TiO	tio	NN
cord-006229-7yoilsho	3490	10	2	2	CD
cord-006229-7yoilsho	3490	11	NP	NP	NNP
cord-006229-7yoilsho	3490	12	triggered	trigger	VBD
cord-006229-7yoilsho	3490	13	a	a	DT
cord-006229-7yoilsho	3490	14	moderate	moderate	JJ
cord-006229-7yoilsho	3490	15	induction	induction	NN
cord-006229-7yoilsho	3490	16	of	of	IN
cord-006229-7yoilsho	3490	17	oxidative	oxidative	JJ
cord-006229-7yoilsho	3490	18	stress	stress	NN
cord-006229-7yoilsho	3490	19	.	.	.
cord-006229-7yoilsho	3491	1	IL-6	IL-6	NNP
cord-006229-7yoilsho	3491	2	was	be	VBD
cord-006229-7yoilsho	3491	3	only	only	RB
cord-006229-7yoilsho	3491	4	induced	induce	VBN
cord-006229-7yoilsho	3491	5	after	after	IN
cord-006229-7yoilsho	3491	6	SiO	SiO	NNP
cord-006229-7yoilsho	3491	7	2	2	CD
cord-006229-7yoilsho	3491	8	treatment	treatment	NN
cord-006229-7yoilsho	3491	9	,	,	,
cord-006229-7yoilsho	3491	10	whereas	whereas	IN
cord-006229-7yoilsho	3491	11	IL-18	IL-18	NNP
cord-006229-7yoilsho	3491	12	was	be	VBD
cord-006229-7yoilsho	3491	13	not	not	RB
cord-006229-7yoilsho	3491	14	affected	affect	VBN
cord-006229-7yoilsho	3491	15	by	by	IN
cord-006229-7yoilsho	3491	16	any	any	DT
cord-006229-7yoilsho	3491	17	of	of	IN
cord-006229-7yoilsho	3491	18	the	the	DT
cord-006229-7yoilsho	3491	19	tested	test	VBN
cord-006229-7yoilsho	3491	20	NP	NP	NNP
cord-006229-7yoilsho	3491	21	.	.	.
cord-006229-7yoilsho	3492	1	In	in	IN
cord-006229-7yoilsho	3492	2	contrast	contrast	NN
cord-006229-7yoilsho	3492	3	,	,	,
cord-006229-7yoilsho	3492	4	various	various	JJ
cord-006229-7yoilsho	3492	5	TiO	tio	NN
cord-006229-7yoilsho	3492	6	2	2	CD
cord-006229-7yoilsho	3492	7	NP	NP	NNP
cord-006229-7yoilsho	3492	8	caused	cause	VBD
cord-006229-7yoilsho	3492	9	a	a	DT
cord-006229-7yoilsho	3492	10	significant	significant	JJ
cord-006229-7yoilsho	3492	11	induction	induction	NN
cord-006229-7yoilsho	3492	12	of	of	IN
cord-006229-7yoilsho	3492	13	IL-1β	IL-1β	NNP
cord-006229-7yoilsho	3492	14	mRNA	mRNA	NNP
cord-006229-7yoilsho	3492	15	expression	expression	NN
cord-006229-7yoilsho	3492	16	.	.	.
cord-006229-7yoilsho	3493	1	However	however	RB
cord-006229-7yoilsho	3493	2	,	,	,
cord-006229-7yoilsho	3493	3	no	no	DT
cord-006229-7yoilsho	3493	4	significant	significant	JJ
cord-006229-7yoilsho	3493	5	induction	induction	NN
cord-006229-7yoilsho	3493	6	of	of	IN
cord-006229-7yoilsho	3493	7	IL-1β	IL-1β	NNP
cord-006229-7yoilsho	3493	8	and	and	CC
cord-006229-7yoilsho	3493	9	TNF	TNF	NNP
cord-006229-7yoilsho	3493	10	-	-	HYPH
cord-006229-7yoilsho	3493	11	α	α	NNP
cord-006229-7yoilsho	3493	12	protein	protein	NN
cord-006229-7yoilsho	3493	13	secretion	secretion	NN
cord-006229-7yoilsho	3493	14	was	be	VBD
cord-006229-7yoilsho	3493	15	observed	observe	VBN
cord-006229-7yoilsho	3493	16	for	for	IN
cord-006229-7yoilsho	3493	17	any	any	DT
cord-006229-7yoilsho	3493	18	of	of	IN
cord-006229-7yoilsho	3493	19	the	the	DT
cord-006229-7yoilsho	3493	20	TiO	tio	JJ
cord-006229-7yoilsho	3493	21	2	2	CD
cord-006229-7yoilsho	3493	22	NP	NP	NNP
cord-006229-7yoilsho	3493	23	.	.	.
cord-006229-7yoilsho	3494	1	The	the	DT
cord-006229-7yoilsho	3494	2	results	result	NNS
cord-006229-7yoilsho	3494	3	obtained	obtain	VBN
cord-006229-7yoilsho	3494	4	from	from	IN
cord-006229-7yoilsho	3494	5	these	these	DT
cord-006229-7yoilsho	3494	6	and	and	CC
cord-006229-7yoilsho	3494	7	ongoing	ongoing	JJ
cord-006229-7yoilsho	3494	8	investigations	investigation	NNS
cord-006229-7yoilsho	3494	9	will	will	MD
cord-006229-7yoilsho	3494	10	be	be	VB
cord-006229-7yoilsho	3494	11	linked	link	VBN
cord-006229-7yoilsho	3494	12	to	to	IN
cord-006229-7yoilsho	3494	13	the	the	DT
cord-006229-7yoilsho	3494	14	physico	physico	NN
cord-006229-7yoilsho	3494	15	-	-	HYPH
cord-006229-7yoilsho	3494	16	chemical	chemical	NN
cord-006229-7yoilsho	3494	17	database	database	NN
cord-006229-7yoilsho	3494	18	as	as	IN
cord-006229-7yoilsho	3494	19	being	be	VBG
cord-006229-7yoilsho	3494	20	developed	develop	VBN
cord-006229-7yoilsho	3494	21	for	for	IN
cord-006229-7yoilsho	3494	22	all	all	DT
cord-006229-7yoilsho	3494	23	TiO	tio	JJ
cord-006229-7yoilsho	3494	24	2	2	CD
cord-006229-7yoilsho	3494	25	NP	NP	NNP
cord-006229-7yoilsho	3494	26	within	within	IN
cord-006229-7yoilsho	3494	27	the	the	DT
cord-006229-7yoilsho	3494	28	SETNanoMetro	setnanometro	NN
cord-006229-7yoilsho	3494	29	project	project	NN
cord-006229-7yoilsho	3494	30	,	,	,
cord-006229-7yoilsho	3494	31	with	with	IN
cord-006229-7yoilsho	3494	32	the	the	DT
cord-006229-7yoilsho	3494	33	overall	overall	JJ
cord-006229-7yoilsho	3494	34	aim	aim	NN
cord-006229-7yoilsho	3494	35	to	to	TO
cord-006229-7yoilsho	3494	36	build	build	VB
cord-006229-7yoilsho	3494	37	and	and	CC
cord-006229-7yoilsho	3494	38	model	model	VB
cord-006229-7yoilsho	3494	39	nano	nano	NN
cord-006229-7yoilsho	3494	40	-	-	HYPH
cord-006229-7yoilsho	3494	41	structure	structure	NN
cord-006229-7yoilsho	3494	42	activity	activity	NN
cord-006229-7yoilsho	3494	43	relationships	relationship	NNS
cord-006229-7yoilsho	3494	44	(	(	-LRB-
cord-006229-7yoilsho	3494	45	NSAR	NSAR	NNP
cord-006229-7yoilsho	3494	46	)	)	-RRB-
cord-006229-7yoilsho	3494	47	for	for	IN
cord-006229-7yoilsho	3494	48	this	this	DT
cord-006229-7yoilsho	3494	49	widely	widely	RB
cord-006229-7yoilsho	3494	50	applied	applied	JJ
cord-006229-7yoilsho	3494	51	type	type	NN
cord-006229-7yoilsho	3494	52	of	of	IN
cord-006229-7yoilsho	3494	53	nanomaterial	nanomaterial	NN
cord-006229-7yoilsho	3494	54	.	.	.
cord-006229-7yoilsho	3495	1	Acknowledgements	acknowledgement	NNS
cord-006229-7yoilsho	3495	2	:	:	:
cord-006229-7yoilsho	3496	1	The	the	DT
cord-006229-7yoilsho	3496	2	SETNanoMetro	setnanometro	NN
cord-006229-7yoilsho	3496	3	project	project	NN
cord-006229-7yoilsho	3496	4	is	be	VBZ
cord-006229-7yoilsho	3496	5	supported	support	VBN
cord-006229-7yoilsho	3496	6	by	by	IN
cord-006229-7yoilsho	3496	7	the	the	DT
cord-006229-7yoilsho	3496	8	EU	EU	NNP
cord-006229-7yoilsho	3496	9	-	-	HYPH
cord-006229-7yoilsho	3496	10	FP7	FP7	NNP
cord-006229-7yoilsho	3496	11	Programme	Programme	NNP
cord-006229-7yoilsho	3496	12	.	.	.
cord-006229-7yoilsho	3497	1	Specific	specific	JJ
cord-006229-7yoilsho	3497	2	types	type	NNS
cord-006229-7yoilsho	3497	3	of	of	IN
cord-006229-7yoilsho	3497	4	TiO	tio	NN
cord-006229-7yoilsho	3497	5	2	2	CD
cord-006229-7yoilsho	3497	6	particles	particle	NNS
cord-006229-7yoilsho	3497	7	were	be	VBD
cord-006229-7yoilsho	3497	8	obtained	obtain	VBN
cord-006229-7yoilsho	3497	9	by	by	IN
cord-006229-7yoilsho	3497	10	Solaronix	Solaronix	NNP
cord-006229-7yoilsho	3497	11	(	(	-LRB-
cord-006229-7yoilsho	3497	12	Switzerland	Switzerland	NNP
cord-006229-7yoilsho	3497	13	)	)	-RRB-
cord-006229-7yoilsho	3497	14	,	,	,
cord-006229-7yoilsho	3497	15	Evonik	Evonik	NNP
cord-006229-7yoilsho	3497	16	and	and	CC
cord-006229-7yoilsho	3497	17	Cristal	Cristal	NNP
cord-006229-7yoilsho	3497	18	.	.	.
cord-006229-7yoilsho	3498	1	Potential	potential	NN
cord-006229-7yoilsho	3498	2	of	of	IN
cord-006229-7yoilsho	3498	3	silver	silver	NN
cord-006229-7yoilsho	3498	4	and	and	CC
cord-006229-7yoilsho	3498	5	silver	silver	NN
cord-006229-7yoilsho	3498	6	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	3498	7	to	to	TO
cord-006229-7yoilsho	3498	8	reduce	reduce	VB
cord-006229-7yoilsho	3498	9	N	n	CD
cord-006229-7yoilsho	3498	10	-	-	HYPH
cord-006229-7yoilsho	3498	11	acetyltransferase	acetyltransferase	NNP
cord-006229-7yoilsho	3498	12	1	1	CD
cord-006229-7yoilsho	3498	13	(	(	-LRB-
cord-006229-7yoilsho	3498	14	NAT1	NAT1	NNP
cord-006229-7yoilsho	3498	15	)	)	-RRB-
cord-006229-7yoilsho	3498	16	activity	activity	NN
cord-006229-7yoilsho	3498	17	J.	J.	NNP
cord-006229-7yoilsho	3498	18	Lichter	Lichter	NNP
cord-006229-7yoilsho	3498	19	1	1	CD
cord-006229-7yoilsho	3498	20	,	,	,
cord-006229-7yoilsho	3498	21	B.	B.	NNP
cord-006229-7yoilsho	3498	22	Blömeke	Blömeke	NNP
cord-006229-7yoilsho	3498	23	1	1	CD
cord-006229-7yoilsho	3498	24	1	1	CD
cord-006229-7yoilsho	3498	25	Trier	Trier	NNP
cord-006229-7yoilsho	3498	26	University	University	NNP
cord-006229-7yoilsho	3498	27	,	,	,
cord-006229-7yoilsho	3498	28	Department	Department	NNP
cord-006229-7yoilsho	3498	29	of	of	IN
cord-006229-7yoilsho	3498	30	Environmental	Environmental	NNP
cord-006229-7yoilsho	3498	31	Toxicology	Toxicology	NNP
cord-006229-7yoilsho	3498	32	,	,	,
cord-006229-7yoilsho	3498	33	Trier	Trier	NNP
cord-006229-7yoilsho	3498	34	,	,	,
cord-006229-7yoilsho	3498	35	Germany	Germany	NNP
cord-006229-7yoilsho	3498	36	Humans	Humans	NNPS
cord-006229-7yoilsho	3498	37	are	be	VBP
cord-006229-7yoilsho	3498	38	exposed	expose	VBN
cord-006229-7yoilsho	3498	39	to	to	IN
cord-006229-7yoilsho	3498	40	various	various	JJ
cord-006229-7yoilsho	3498	41	kinds	kind	NNS
cord-006229-7yoilsho	3498	42	of	of	IN
cord-006229-7yoilsho	3498	43	engineered	engineer	VBN
cord-006229-7yoilsho	3498	44	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	3498	45	including	include	VBG
cord-006229-7yoilsho	3498	46	silver	silver	NN
cord-006229-7yoilsho	3498	47	,	,	,
cord-006229-7yoilsho	3498	48	which	which	WDT
cord-006229-7yoilsho	3498	49	is	be	VBZ
cord-006229-7yoilsho	3498	50	frequently	frequently	RB
cord-006229-7yoilsho	3498	51	used	use	VBN
cord-006229-7yoilsho	3498	52	in	in	IN
cord-006229-7yoilsho	3498	53	consumer	consumer	NN
cord-006229-7yoilsho	3498	54	and	and	CC
cord-006229-7yoilsho	3498	55	biomedical	biomedical	JJ
cord-006229-7yoilsho	3498	56	product	product	NN
cord-006229-7yoilsho	3498	57	due	due	IN
cord-006229-7yoilsho	3498	58	to	to	IN
cord-006229-7yoilsho	3498	59	its	-PRON-	PRP$
cord-006229-7yoilsho	3498	60	bactericide	bactericide	NN
cord-006229-7yoilsho	3498	61	properties	property	NNS
cord-006229-7yoilsho	3498	62	.	.	.
cord-006229-7yoilsho	3499	1	Despite	despite	IN
cord-006229-7yoilsho	3499	2	their	-PRON-	PRP$
cord-006229-7yoilsho	3499	3	widespread	widespread	JJ
cord-006229-7yoilsho	3499	4	usage	usage	NN
cord-006229-7yoilsho	3499	5	,	,	,
cord-006229-7yoilsho	3499	6	knowledge	knowledge	NN
cord-006229-7yoilsho	3499	7	about	about	IN
cord-006229-7yoilsho	3499	8	influences	influence	NNS
cord-006229-7yoilsho	3499	9	on	on	IN
cord-006229-7yoilsho	3499	10	cellular	cellular	JJ
cord-006229-7yoilsho	3499	11	functions	function	NNS
cord-006229-7yoilsho	3499	12	is	be	VBZ
cord-006229-7yoilsho	3499	13	still	still	RB
cord-006229-7yoilsho	3499	14	incomplete	incomplete	JJ
cord-006229-7yoilsho	3499	15	.	.	.
cord-006229-7yoilsho	3500	1	N	n	CD
cord-006229-7yoilsho	3500	2	-	-	HYPH
cord-006229-7yoilsho	3500	3	acetyltransferase	acetyltransferase	NNP
cord-006229-7yoilsho	3500	4	1	1	CD
cord-006229-7yoilsho	3500	5	(	(	-LRB-
cord-006229-7yoilsho	3500	6	NAT1	NAT1	NNP
cord-006229-7yoilsho	3500	7	)	)	-RRB-
cord-006229-7yoilsho	3500	8	,	,	,
cord-006229-7yoilsho	3500	9	an	an	DT
cord-006229-7yoilsho	3500	10	enzyme	enzyme	NN
cord-006229-7yoilsho	3500	11	which	which	WDT
cord-006229-7yoilsho	3500	12	is	be	VBZ
cord-006229-7yoilsho	3500	13	ubiquitously	ubiquitously	RB
cord-006229-7yoilsho	3500	14	expressed	express	VBN
cord-006229-7yoilsho	3500	15	in	in	IN
cord-006229-7yoilsho	3500	16	human	human	JJ
cord-006229-7yoilsho	3500	17	tissues	tissue	NNS
cord-006229-7yoilsho	3500	18	,	,	,
cord-006229-7yoilsho	3500	19	catalyzes	catalyze	VBZ
cord-006229-7yoilsho	3500	20	the	the	DT
cord-006229-7yoilsho	3500	21	transfer	transfer	NN
cord-006229-7yoilsho	3500	22	of	of	IN
cord-006229-7yoilsho	3500	23	an	an	DT
cord-006229-7yoilsho	3500	24	acetyl	acetyl	NN
cord-006229-7yoilsho	3500	25	group	group	NN
cord-006229-7yoilsho	3500	26	to	to	IN
cord-006229-7yoilsho	3500	27	its	-PRON-	PRP$
cord-006229-7yoilsho	3500	28	substrates	substrate	NNS
cord-006229-7yoilsho	3500	29	and	and	CC
cord-006229-7yoilsho	3500	30	although	although	IN
cord-006229-7yoilsho	3500	31	its	-PRON-	PRP$
cord-006229-7yoilsho	3500	32	endogenous	endogenous	JJ
cord-006229-7yoilsho	3500	33	function	function	NN
cord-006229-7yoilsho	3500	34	is	be	VBZ
cord-006229-7yoilsho	3500	35	not	not	RB
cord-006229-7yoilsho	3500	36	clear	clear	JJ
cord-006229-7yoilsho	3500	37	yet	yet	RB
cord-006229-7yoilsho	3500	38	,	,	,
cord-006229-7yoilsho	3500	39	it	-PRON-	PRP
cord-006229-7yoilsho	3500	40	is	be	VBZ
cord-006229-7yoilsho	3500	41	well	well	RB
cord-006229-7yoilsho	3500	42	known	known	JJ
cord-006229-7yoilsho	3500	43	to	to	TO
cord-006229-7yoilsho	3500	44	be	be	VB
cord-006229-7yoilsho	3500	45	involved	involve	VBN
cord-006229-7yoilsho	3500	46	in	in	IN
cord-006229-7yoilsho	3500	47	the	the	DT
cord-006229-7yoilsho	3500	48	N	n	NN
cord-006229-7yoilsho	3500	49	-	-	HYPH
cord-006229-7yoilsho	3500	50	acetylation	acetylation	NN
cord-006229-7yoilsho	3500	51	of	of	IN
cord-006229-7yoilsho	3500	52	arylamines	arylamine	NNS
cord-006229-7yoilsho	3500	53	.	.	.
cord-006229-7yoilsho	3501	1	In	in	IN
cord-006229-7yoilsho	3501	2	addition	addition	NN
cord-006229-7yoilsho	3501	3	NAT1	NAT1	NNP
cord-006229-7yoilsho	3501	4	enzyme	enzyme	NN
cord-006229-7yoilsho	3501	5	activity	activity	NN
cord-006229-7yoilsho	3501	6	is	be	VBZ
cord-006229-7yoilsho	3501	7	known	know	VBN
cord-006229-7yoilsho	3501	8	to	to	IN
cord-006229-7yoilsho	3501	9	modulated	modulate	VBN
cord-006229-7yoilsho	3501	10	by	by	IN
cord-006229-7yoilsho	3501	11	non	non	JJ
cord-006229-7yoilsho	3501	12	-	-	NNS
cord-006229-7yoilsho	3501	13	substrates	substrate	NNS
cord-006229-7yoilsho	3501	14	including	include	VBG
cord-006229-7yoilsho	3501	15	metals	metal	NNS
cord-006229-7yoilsho	3501	16	and	and	CC
cord-006229-7yoilsho	3501	17	certain	certain	JJ
cord-006229-7yoilsho	3501	18	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	3501	19	,	,	,
cord-006229-7yoilsho	3501	20	however	however	RB
cord-006229-7yoilsho	3501	21	,	,	,
cord-006229-7yoilsho	3501	22	the	the	DT
cord-006229-7yoilsho	3501	23	influence	influence	NN
cord-006229-7yoilsho	3501	24	of	of	IN
cord-006229-7yoilsho	3501	25	silver	silver	NN
cord-006229-7yoilsho	3501	26	on	on	IN
cord-006229-7yoilsho	3501	27	NAT1	NAT1	NNP
cord-006229-7yoilsho	3501	28	has	have	VBZ
cord-006229-7yoilsho	3501	29	not	not	RB
cord-006229-7yoilsho	3501	30	been	be	VBN
cord-006229-7yoilsho	3501	31	analyzed	analyze	VBN
cord-006229-7yoilsho	3501	32	yet	yet	RB
cord-006229-7yoilsho	3501	33	.	.	.
cord-006229-7yoilsho	3502	1	To	to	TO
cord-006229-7yoilsho	3502	2	address	address	VB
cord-006229-7yoilsho	3502	3	whether	whether	IN
cord-006229-7yoilsho	3502	4	human	human	JJ
cord-006229-7yoilsho	3502	5	NAT1	NAT1	NNP
cord-006229-7yoilsho	3502	6	is	be	VBZ
cord-006229-7yoilsho	3502	7	a	a	DT
cord-006229-7yoilsho	3502	8	target	target	NN
cord-006229-7yoilsho	3502	9	of	of	IN
cord-006229-7yoilsho	3502	10	silver	silver	NN
cord-006229-7yoilsho	3502	11	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	3502	12	and	and	CC
cord-006229-7yoilsho	3502	13	released	release	VBN
cord-006229-7yoilsho	3502	14	irons	iron	NNS
cord-006229-7yoilsho	3502	15	on	on	IN
cord-006229-7yoilsho	3502	16	protein	protein	NN
cord-006229-7yoilsho	3502	17	,	,	,
cord-006229-7yoilsho	3502	18	purified	purify	VBN
cord-006229-7yoilsho	3502	19	NAT1	NAT1	NNP
cord-006229-7yoilsho	3502	20	was	be	VBD
cord-006229-7yoilsho	3502	21	exposed	expose	VBN
cord-006229-7yoilsho	3502	22	to	to	IN
cord-006229-7yoilsho	3502	23	silver	silver	NN
cord-006229-7yoilsho	3502	24	ions	ion	NNS
cord-006229-7yoilsho	3502	25	(	(	-LRB-
cord-006229-7yoilsho	3502	26	AgNO	AgNO	NNP
cord-006229-7yoilsho	3502	27	3	3	CD
cord-006229-7yoilsho	3502	28	)	)	-RRB-
cord-006229-7yoilsho	3502	29	and	and	CC
cord-006229-7yoilsho	3502	30	silver	silver	NN
cord-006229-7yoilsho	3502	31	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	3502	32	(	(	-LRB-
cord-006229-7yoilsho	3502	33	Ag10-COOH	Ag10-COOH	NNP
cord-006229-7yoilsho	3502	34	,	,	,
cord-006229-7yoilsho	3502	35	average	average	JJ
cord-006229-7yoilsho	3502	36	size	size	NN
cord-006229-7yoilsho	3502	37	10	10	CD
cord-006229-7yoilsho	3502	38	nm	nm	NN
cord-006229-7yoilsho	3502	39	,	,	,
cord-006229-7yoilsho	3503	1	carboxyl	carboxyl	NN
cord-006229-7yoilsho	3503	2	functionalized	functionalize	VBN
cord-006229-7yoilsho	3503	3	)	)	-RRB-
cord-006229-7yoilsho	3503	4	,	,	,
cord-006229-7yoilsho	3503	5	and	and	CC
cord-006229-7yoilsho	3503	6	NAT1	NAT1	NNP
cord-006229-7yoilsho	3503	7	enzyme	enzyme	NN
cord-006229-7yoilsho	3503	8	activity	activity	NN
cord-006229-7yoilsho	3503	9	was	be	VBD
cord-006229-7yoilsho	3503	10	analyzing	analyze	VBG
cord-006229-7yoilsho	3503	11	the	the	DT
cord-006229-7yoilsho	3503	12	N	n	CD
cord-006229-7yoilsho	3503	13	-	-	HYPH
cord-006229-7yoilsho	3503	14	acetylation	acetylation	NN
cord-006229-7yoilsho	3503	15	of	of	IN
cord-006229-7yoilsho	3503	16	the	the	DT
cord-006229-7yoilsho	3503	17	NAT1	NAT1	NNP
cord-006229-7yoilsho	3503	18	substrate	substrate	NN
cord-006229-7yoilsho	3503	19	para	para	NNP
cord-006229-7yoilsho	3503	20	-	-	HYPH
cord-006229-7yoilsho	3503	21	aminobenzoic	aminobenzoic	JJ
cord-006229-7yoilsho	3503	22	acid	acid	NN
cord-006229-7yoilsho	3503	23	(	(	-LRB-
cord-006229-7yoilsho	3503	24	PABA	PABA	NNP
cord-006229-7yoilsho	3503	25	)	)	-RRB-
cord-006229-7yoilsho	3503	26	.	.	.
cord-006229-7yoilsho	3504	1	Therefore	therefore	RB
cord-006229-7yoilsho	3504	2	,	,	,
cord-006229-7yoilsho	3504	3	purified	purify	VBN
cord-006229-7yoilsho	3504	4	NAT1	NAT1	NNP
cord-006229-7yoilsho	3504	5	(	(	-LRB-
cord-006229-7yoilsho	3504	6	1	1	CD
cord-006229-7yoilsho	3504	7	ng/µl	ng/µl	CD
cord-006229-7yoilsho	3504	8	)	)	-RRB-
cord-006229-7yoilsho	3504	9	was	be	VBD
cord-006229-7yoilsho	3504	10	co	co	VBN
cord-006229-7yoilsho	3504	11	-	-	VBN
cord-006229-7yoilsho	3504	12	exposed	expose	VBN
cord-006229-7yoilsho	3504	13	for	for	IN
cord-006229-7yoilsho	3504	14	20	20	CD
cord-006229-7yoilsho	3504	15	min	min	NN
cord-006229-7yoilsho	3504	16	to	to	IN
cord-006229-7yoilsho	3504	17	PABA	PABA	NNP
cord-006229-7yoilsho	3504	18	(	(	-LRB-
cord-006229-7yoilsho	3504	19	1	1	CD
cord-006229-7yoilsho	3504	20	mM	mm	CD
cord-006229-7yoilsho	3504	21	)	)	-RRB-
cord-006229-7yoilsho	3505	1	and	and	CC
cord-006229-7yoilsho	3505	2	AgNO	AgNO	NNP
cord-006229-7yoilsho	3505	3	3	3	CD
cord-006229-7yoilsho	3505	4	or	or	CC
cord-006229-7yoilsho	3505	5	Ag10-COOH	Ag10-COOH	NNP
cord-006229-7yoilsho	3505	6	(	(	-LRB-
cord-006229-7yoilsho	3505	7	0.01	0.01	CD
cord-006229-7yoilsho	3505	8	,	,	,
cord-006229-7yoilsho	3505	9	0.1	0.1	CD
cord-006229-7yoilsho	3505	10	,	,	,
cord-006229-7yoilsho	3505	11	1	1	CD
cord-006229-7yoilsho	3505	12	,	,	,
cord-006229-7yoilsho	3505	13	10	10	CD
cord-006229-7yoilsho	3505	14	and	and	CC
cord-006229-7yoilsho	3505	15	100	100	CD
cord-006229-7yoilsho	3505	16	µg	µg	NN
cord-006229-7yoilsho	3505	17	/	/	SYM
cord-006229-7yoilsho	3505	18	ml	ml	XX
cord-006229-7yoilsho	3505	19	each	each	DT
cord-006229-7yoilsho	3505	20	)	)	-RRB-
cord-006229-7yoilsho	3505	21	,	,	,
cord-006229-7yoilsho	3505	22	resulting	result	VBG
cord-006229-7yoilsho	3505	23	in	in	IN
cord-006229-7yoilsho	3505	24	a	a	DT
cord-006229-7yoilsho	3505	25	NAT1	NAT1	NNP
cord-006229-7yoilsho	3505	26	:	:	:
cord-006229-7yoilsho	3505	27	silver	silver	JJ
cord-006229-7yoilsho	3505	28	relation	relation	NN
cord-006229-7yoilsho	3505	29	of	of	IN
cord-006229-7yoilsho	3505	30	1:0.01	1:0.01	CD
cord-006229-7yoilsho	3505	31	-	-	HYPH
cord-006229-7yoilsho	3505	32	100	100	CD
cord-006229-7yoilsho	3505	33	(	(	-LRB-
cord-006229-7yoilsho	3505	34	w	w	NNP
cord-006229-7yoilsho	3505	35	/	/	SYM
cord-006229-7yoilsho	3505	36	w	w	NN
cord-006229-7yoilsho	3505	37	)	)	-RRB-
cord-006229-7yoilsho	3505	38	.	.	.
cord-006229-7yoilsho	3506	1	Both	both	DT
cord-006229-7yoilsho	3506	2	,	,	,
cord-006229-7yoilsho	3506	3	AgNO	AgNO	NNP
cord-006229-7yoilsho	3506	4	3	3	CD
cord-006229-7yoilsho	3506	5	and	and	CC
cord-006229-7yoilsho	3506	6	Ag10-COOH	Ag10-COOH	NNP
cord-006229-7yoilsho	3506	7	inhibited	inhibit	VBD
cord-006229-7yoilsho	3506	8	the	the	DT
cord-006229-7yoilsho	3506	9	N	n	NN
cord-006229-7yoilsho	3506	10	-	-	HYPH
cord-006229-7yoilsho	3506	11	acetylation	acetylation	NN
cord-006229-7yoilsho	3506	12	of	of	IN
cord-006229-7yoilsho	3506	13	PABA	PABA	NNP
cord-006229-7yoilsho	3506	14	in	in	IN
cord-006229-7yoilsho	3506	15	a	a	DT
cord-006229-7yoilsho	3506	16	concentration	concentration	NN
cord-006229-7yoilsho	3506	17	dependent	dependent	JJ
cord-006229-7yoilsho	3506	18	manner	manner	NN
cord-006229-7yoilsho	3506	19	.	.	.
cord-006229-7yoilsho	3507	1	Using	use	VBG
cord-006229-7yoilsho	3507	2	equal	equal	JJ
cord-006229-7yoilsho	3507	3	amounts	amount	NNS
cord-006229-7yoilsho	3507	4	of	of	IN
cord-006229-7yoilsho	3507	5	silver	silver	NN
cord-006229-7yoilsho	3507	6	and	and	CC
cord-006229-7yoilsho	3507	7	NAT1	NAT1	NNP
cord-006229-7yoilsho	3508	1	(	(	-LRB-
cord-006229-7yoilsho	3508	2	w	w	NNP
cord-006229-7yoilsho	3508	3	/	/	SYM
cord-006229-7yoilsho	3508	4	w	w	NNP
cord-006229-7yoilsho	3508	5	,	,	,
cord-006229-7yoilsho	3508	6	1	1	CD
cord-006229-7yoilsho	3508	7	µg	µg	NN
cord-006229-7yoilsho	3508	8	/	/	SYM
cord-006229-7yoilsho	3508	9	ml	ml	NN
cord-006229-7yoilsho	3508	10	)	)	-RRB-
cord-006229-7yoilsho	3509	1	enzyme	enzyme	NN
cord-006229-7yoilsho	3509	2	activity	activity	NN
cord-006229-7yoilsho	3509	3	was	be	VBD
cord-006229-7yoilsho	3509	4	reduced	reduce	VBN
cord-006229-7yoilsho	3509	5	about	about	IN
cord-006229-7yoilsho	3509	6	98±0.2	98±0.2	CD
cord-006229-7yoilsho	3509	7	%	%	NN
cord-006229-7yoilsho	3509	8	(	(	-LRB-
cord-006229-7yoilsho	3509	9	AgNO	AgNO	NNP
cord-006229-7yoilsho	3509	10	3	3	CD
cord-006229-7yoilsho	3509	11	)	)	-RRB-
cord-006229-7yoilsho	3509	12	and	and	CC
cord-006229-7yoilsho	3509	13	82±0.6	82±0.6	CD
cord-006229-7yoilsho	3509	14	%	%	NN
cord-006229-7yoilsho	3509	15	(	(	-LRB-
cord-006229-7yoilsho	3509	16	Ag10-COOH	Ag10-COOH	NNP
cord-006229-7yoilsho	3509	17	)	)	-RRB-
cord-006229-7yoilsho	3509	18	.	.	.
cord-006229-7yoilsho	3510	1	The	the	DT
cord-006229-7yoilsho	3510	2	lowest	low	JJS
cord-006229-7yoilsho	3510	3	concentration	concentration	NN
cord-006229-7yoilsho	3510	4	analyzed	analyze	VBD
cord-006229-7yoilsho	3510	5	(	(	-LRB-
cord-006229-7yoilsho	3510	6	0.01	0.01	CD
cord-006229-7yoilsho	3510	7	µg	µg	NN
cord-006229-7yoilsho	3510	8	/	/	SYM
cord-006229-7yoilsho	3510	9	ml	ml	NN
cord-006229-7yoilsho	3510	10	)	)	-RRB-
cord-006229-7yoilsho	3510	11	reduced	reduce	VBD
cord-006229-7yoilsho	3510	12	NAT1	NAT1	NNP
cord-006229-7yoilsho	3510	13	activity	activity	NN
cord-006229-7yoilsho	3510	14	about	about	IN
cord-006229-7yoilsho	3510	15	24±5	24±5	CD
cord-006229-7yoilsho	3510	16	%	%	NN
cord-006229-7yoilsho	3510	17	(	(	-LRB-
cord-006229-7yoilsho	3510	18	AgNO	AgNO	NNP
cord-006229-7yoilsho	3510	19	3	3	CD
cord-006229-7yoilsho	3510	20	)	)	-RRB-
cord-006229-7yoilsho	3510	21	and	and	CC
cord-006229-7yoilsho	3510	22	17±5	17±5	CD
cord-006229-7yoilsho	3510	23	%	%	NN
cord-006229-7yoilsho	3510	24	(	(	-LRB-
cord-006229-7yoilsho	3510	25	Ag10-COOH	Ag10-COOH	NNP
cord-006229-7yoilsho	3510	26	)	)	-RRB-
cord-006229-7yoilsho	3510	27	.	.	.
cord-006229-7yoilsho	3511	1	Fifty	fifty	CD
cord-006229-7yoilsho	3511	2	percent	percent	NN
cord-006229-7yoilsho	3511	3	activity	activity	NN
cord-006229-7yoilsho	3511	4	reduction	reduction	NN
cord-006229-7yoilsho	3511	5	was	be	VBD
cord-006229-7yoilsho	3511	6	caused	cause	VBN
cord-006229-7yoilsho	3511	7	by	by	IN
cord-006229-7yoilsho	3511	8	0.11	0.11	CD
cord-006229-7yoilsho	3511	9	±	±	NN
cord-006229-7yoilsho	3512	1	0.01	0.01	CD
cord-006229-7yoilsho	3512	2	µg	µg	NNP
cord-006229-7yoilsho	3512	3	/	/	SYM
cord-006229-7yoilsho	3512	4	ml	ml	NN
cord-006229-7yoilsho	3512	5	of	of	IN
cord-006229-7yoilsho	3512	6	AgNO	AgNO	NNP
cord-006229-7yoilsho	3512	7	3	3	CD
cord-006229-7yoilsho	3512	8	and	and	CC
cord-006229-7yoilsho	3512	9	0.21	0.21	CD
cord-006229-7yoilsho	3512	10	±	±	CD
cord-006229-7yoilsho	3512	11	0.04	0.04	CD
cord-006229-7yoilsho	3512	12	µg	µg	NN
cord-006229-7yoilsho	3512	13	/	/	SYM
cord-006229-7yoilsho	3512	14	ml	ml	NN
cord-006229-7yoilsho	3512	15	of	of	IN
cord-006229-7yoilsho	3512	16	Ag10-COOH	Ag10-COOH	NNP
cord-006229-7yoilsho	3512	17	,	,	,
cord-006229-7yoilsho	3512	18	which	which	WDT
cord-006229-7yoilsho	3512	19	is	be	VBZ
cord-006229-7yoilsho	3512	20	10-fold	10-fold	JJ
cord-006229-7yoilsho	3512	21	lower	low	JJR
cord-006229-7yoilsho	3512	22	compared	compare	VBN
cord-006229-7yoilsho	3512	23	to	to	IN
cord-006229-7yoilsho	3512	24	the	the	DT
cord-006229-7yoilsho	3512	25	published	publish	VBN
cord-006229-7yoilsho	3512	26	IC50	IC50	NNP
cord-006229-7yoilsho	3512	27	values	value	NNS
cord-006229-7yoilsho	3512	28	for	for	IN
cord-006229-7yoilsho	3512	29	other	other	JJ
cord-006229-7yoilsho	3512	30	metal	metal	NN
cord-006229-7yoilsho	3512	31	oxide	oxide	NN
cord-006229-7yoilsho	3512	32	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	3512	33	(	(	-LRB-
cord-006229-7yoilsho	3512	34	3	3	CD
cord-006229-7yoilsho	3512	35	-	-	SYM
cord-006229-7yoilsho	3512	36	15	15	CD
cord-006229-7yoilsho	3512	37	µg	µg	NN
cord-006229-7yoilsho	3512	38	/	/	SYM
cord-006229-7yoilsho	3512	39	ml	ml	NN
cord-006229-7yoilsho	3512	40	)	)	-RRB-
cord-006229-7yoilsho	3512	41	.	.	.
cord-006229-7yoilsho	3513	1	These	these	DT
cord-006229-7yoilsho	3513	2	data	datum	NNS
cord-006229-7yoilsho	3513	3	indicate	indicate	VBP
cord-006229-7yoilsho	3513	4	that	that	IN
cord-006229-7yoilsho	3513	5	both	both	CC
cord-006229-7yoilsho	3513	6	chemical	chemical	JJ
cord-006229-7yoilsho	3513	7	silver	silver	NN
cord-006229-7yoilsho	3513	8	species	specie	NNS
cord-006229-7yoilsho	3513	9	are	be	VBP
cord-006229-7yoilsho	3513	10	able	able	JJ
cord-006229-7yoilsho	3513	11	to	to	TO
cord-006229-7yoilsho	3513	12	modulate	modulate	VB
cord-006229-7yoilsho	3513	13	PABA	PABA	NNP
cord-006229-7yoilsho	3513	14	acetylation	acetylation	NN
cord-006229-7yoilsho	3513	15	.	.	.
cord-006229-7yoilsho	3514	1	Further	further	JJ
cord-006229-7yoilsho	3514	2	studies	study	NNS
cord-006229-7yoilsho	3514	3	will	will	MD
cord-006229-7yoilsho	3514	4	be	be	VB
cord-006229-7yoilsho	3514	5	performed	perform	VBN
cord-006229-7yoilsho	3514	6	to	to	TO
cord-006229-7yoilsho	3514	7	clarify	clarify	VB
cord-006229-7yoilsho	3514	8	whether	whether	IN
cord-006229-7yoilsho	3514	9	silver	silver	JJ
cord-006229-7yoilsho	3514	10	ions	ion	NNS
cord-006229-7yoilsho	3514	11	and/or	and/or	CC
cord-006229-7yoilsho	3514	12	silver	silver	NN
cord-006229-7yoilsho	3514	13	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	3514	14	could	could	MD
cord-006229-7yoilsho	3514	15	affect	affect	VB
cord-006229-7yoilsho	3514	16	the	the	DT
cord-006229-7yoilsho	3514	17	specific	specific	JJ
cord-006229-7yoilsho	3514	18	N	n	CD
cord-006229-7yoilsho	3514	19	-	-	HYPH
cord-006229-7yoilsho	3514	20	acetylation	acetylation	NN
cord-006229-7yoilsho	3514	21	of	of	IN
cord-006229-7yoilsho	3514	22	arylamines	arylamine	NNS
cord-006229-7yoilsho	3514	23	in	in	IN
cord-006229-7yoilsho	3514	24	human	human	JJ
cord-006229-7yoilsho	3514	25	cells	cell	NNS
cord-006229-7yoilsho	3514	26	.	.	.
cord-006229-7yoilsho	3515	1	Colloidal	colloidal	JJ
cord-006229-7yoilsho	3515	2	silver	silver	NN
cord-006229-7yoilsho	3515	3	has	have	VBZ
cord-006229-7yoilsho	3515	4	been	be	VBN
cord-006229-7yoilsho	3515	5	used	use	VBN
cord-006229-7yoilsho	3515	6	in	in	IN
cord-006229-7yoilsho	3515	7	medicine	medicine	NN
cord-006229-7yoilsho	3515	8	for	for	IN
cord-006229-7yoilsho	3515	9	centuries	century	NNS
cord-006229-7yoilsho	3515	10	and	and	CC
cord-006229-7yoilsho	3515	11	nanosilver	nanosilver	NNP
cord-006229-7yoilsho	3515	12	is	be	VBZ
cord-006229-7yoilsho	3515	13	present	present	JJ
cord-006229-7yoilsho	3515	14	in	in	IN
cord-006229-7yoilsho	3515	15	many	many	JJ
cord-006229-7yoilsho	3515	16	consumer	consumer	NN
cord-006229-7yoilsho	3515	17	-	-	HYPH
cord-006229-7yoilsho	3515	18	related	relate	VBN
cord-006229-7yoilsho	3515	19	products	product	NNS
cord-006229-7yoilsho	3515	20	.	.	.
cord-006229-7yoilsho	3516	1	However	however	RB
cord-006229-7yoilsho	3516	2	,	,	,
cord-006229-7yoilsho	3516	3	despite	despite	IN
cord-006229-7yoilsho	3516	4	of	of	IN
cord-006229-7yoilsho	3516	5	intense	intense	JJ
cord-006229-7yoilsho	3516	6	research	research	NN
cord-006229-7yoilsho	3516	7	in	in	IN
cord-006229-7yoilsho	3516	8	the	the	DT
cord-006229-7yoilsho	3516	9	past	past	JJ
cord-006229-7yoilsho	3516	10	few	few	JJ
cord-006229-7yoilsho	3516	11	years	year	NNS
cord-006229-7yoilsho	3516	12	,	,	,
cord-006229-7yoilsho	3516	13	the	the	DT
cord-006229-7yoilsho	3516	14	potential	potential	NN
cord-006229-7yoilsho	3516	15	of	of	IN
cord-006229-7yoilsho	3516	16	nanosilver	nanosilver	NNS
cord-006229-7yoilsho	3516	17	to	to	TO
cord-006229-7yoilsho	3516	18	induce	induce	VB
cord-006229-7yoilsho	3516	19	effects	effect	NNS
cord-006229-7yoilsho	3516	20	different	different	JJ
cord-006229-7yoilsho	3516	21	from	from	IN
cord-006229-7yoilsho	3516	22	ionic	ionic	JJ
cord-006229-7yoilsho	3516	23	silver	silver	NN
cord-006229-7yoilsho	3516	24	in	in	IN
cord-006229-7yoilsho	3516	25	vivo	vivo	NNP
cord-006229-7yoilsho	3516	26	and	and	CC
cord-006229-7yoilsho	3516	27	in	in	IN
cord-006229-7yoilsho	3516	28	vitro	vitro	FW
cord-006229-7yoilsho	3516	29	,	,	,
cord-006229-7yoilsho	3516	30	is	be	VBZ
cord-006229-7yoilsho	3516	31	still	still	RB
cord-006229-7yoilsho	3516	32	under	under	IN
cord-006229-7yoilsho	3516	33	debate	debate	NN
cord-006229-7yoilsho	3516	34	.	.	.
cord-006229-7yoilsho	3517	1	In	in	IN
cord-006229-7yoilsho	3517	2	this	this	DT
cord-006229-7yoilsho	3517	3	study	study	NN
cord-006229-7yoilsho	3517	4	,	,	,
cord-006229-7yoilsho	3517	5	we	-PRON-	PRP
cord-006229-7yoilsho	3517	6	compared	compare	VBD
cord-006229-7yoilsho	3517	7	proteomic	proteomic	JJ
cord-006229-7yoilsho	3517	8	effects	effect	NNS
cord-006229-7yoilsho	3517	9	of	of	IN
cord-006229-7yoilsho	3517	10	nanosilver	nanosilver	NNS
cord-006229-7yoilsho	3517	11	(	(	-LRB-
cord-006229-7yoilsho	3517	12	AgPURE	AgPURE	NNP
cord-006229-7yoilsho	3517	13	™	™	NN
cord-006229-7yoilsho	3517	14	)	)	-RRB-
cord-006229-7yoilsho	3517	15	and	and	CC
cord-006229-7yoilsho	3517	16	ionic	ionic	JJ
cord-006229-7yoilsho	3517	17	silver	silver	NN
cord-006229-7yoilsho	3517	18	(	(	-LRB-
cord-006229-7yoilsho	3517	19	silver	silver	NN
cord-006229-7yoilsho	3517	20	acetate	acetate	NN
cord-006229-7yoilsho	3517	21	)	)	-RRB-
cord-006229-7yoilsho	3517	22	in	in	IN
cord-006229-7yoilsho	3517	23	the	the	DT
cord-006229-7yoilsho	3517	24	kidney	kidney	NN
cord-006229-7yoilsho	3517	25	of	of	IN
cord-006229-7yoilsho	3517	26	male	male	JJ
cord-006229-7yoilsho	3517	27	rats	rat	NNS
cord-006229-7yoilsho	3517	28	after	after	IN
cord-006229-7yoilsho	3517	29	repeated	repeat	VBN
cord-006229-7yoilsho	3517	30	oral	oral	JJ
cord-006229-7yoilsho	3517	31	delivery	delivery	NN
cord-006229-7yoilsho	3517	32	in	in	IN
cord-006229-7yoilsho	3517	33	a	a	DT
cord-006229-7yoilsho	3517	34	rat	rat	NN
cord-006229-7yoilsho	3517	35	28-days	28-days	CD
cord-006229-7yoilsho	3517	36	toxicity	toxicity	NN
cord-006229-7yoilsho	3517	37	study	study	NN
cord-006229-7yoilsho	3517	38	.	.	.
cord-006229-7yoilsho	3518	1	In	in	IN
cord-006229-7yoilsho	3518	2	order	order	NN
cord-006229-7yoilsho	3518	3	to	to	TO
cord-006229-7yoilsho	3518	4	avoid	avoid	VB
cord-006229-7yoilsho	3518	5	overt	overt	JJ
cord-006229-7yoilsho	3518	6	signs	sign	NNS
cord-006229-7yoilsho	3518	7	of	of	IN
cord-006229-7yoilsho	3518	8	toxicity	toxicity	NN
cord-006229-7yoilsho	3518	9	,	,	,
cord-006229-7yoilsho	3518	10	silver	silver	NN
cord-006229-7yoilsho	3518	11	was	be	VBD
cord-006229-7yoilsho	3518	12	dosed	dose	VBN
cord-006229-7yoilsho	3518	13	moderately	moderately	RB
cord-006229-7yoilsho	3518	14	in	in	IN
cord-006229-7yoilsho	3518	15	amounts	amount	NNS
cord-006229-7yoilsho	3518	16	of	of	IN
cord-006229-7yoilsho	3518	17	60	60	CD
cord-006229-7yoilsho	3518	18	and	and	CC
cord-006229-7yoilsho	3518	19	6	6	CD
cord-006229-7yoilsho	3518	20	mg	mg	NNS
cord-006229-7yoilsho	3518	21	/	/	SYM
cord-006229-7yoilsho	3518	22	kg	kg	NN
cord-006229-7yoilsho	3518	23	body	body	NN
cord-006229-7yoilsho	3518	24	weight	weight	NN
cord-006229-7yoilsho	3518	25	for	for	IN
cord-006229-7yoilsho	3518	26	nanosilver	nanosilver	NNS
cord-006229-7yoilsho	3518	27	and	and	CC
cord-006229-7yoilsho	3518	28	corresponding	corresponding	JJ
cord-006229-7yoilsho	3518	29	amounts	amount	NNS
cord-006229-7yoilsho	3518	30	of	of	IN
cord-006229-7yoilsho	3518	31	silver	silver	NN
cord-006229-7yoilsho	3518	32	acetate	acetate	NN
cord-006229-7yoilsho	3518	33	(	(	-LRB-
cord-006229-7yoilsho	3518	34	9.3	9.3	CD
cord-006229-7yoilsho	3518	35	and	and	CC
cord-006229-7yoilsho	3518	36	0.93	0.93	CD
cord-006229-7yoilsho	3518	37	mg	mg	NNS
cord-006229-7yoilsho	3518	38	/	/	SYM
cord-006229-7yoilsho	3518	39	kg	kg	NNP
cord-006229-7yoilsho	3518	40	)	)	-RRB-
cord-006229-7yoilsho	3518	41	.	.	.
cord-006229-7yoilsho	3519	1	Accordingly	accordingly	RB
cord-006229-7yoilsho	3519	2	,	,	,
cord-006229-7yoilsho	3519	3	no	no	DT
cord-006229-7yoilsho	3519	4	pathologic	pathologic	JJ
cord-006229-7yoilsho	3519	5	effects	effect	NNS
cord-006229-7yoilsho	3519	6	,	,	,
cord-006229-7yoilsho	3519	7	including	include	VBG
cord-006229-7yoilsho	3519	8	results	result	NNS
cord-006229-7yoilsho	3519	9	from	from	IN
cord-006229-7yoilsho	3519	10	clinical	clinical	JJ
cord-006229-7yoilsho	3519	11	chemistry	chemistry	NN
cord-006229-7yoilsho	3519	12	and	and	CC
cord-006229-7yoilsho	3519	13	hematology	hematology	NN
cord-006229-7yoilsho	3519	14	,	,	,
cord-006229-7yoilsho	3519	15	were	be	VBD
cord-006229-7yoilsho	3519	16	reported	report	VBN
cord-006229-7yoilsho	3519	17	.	.	.
cord-006229-7yoilsho	3520	1	Kidney	kidney	NN
cord-006229-7yoilsho	3520	2	tissue	tissue	NN
cord-006229-7yoilsho	3520	3	protein	protein	NN
cord-006229-7yoilsho	3520	4	crude	crude	NN
cord-006229-7yoilsho	3520	5	extract	extract	NN
cord-006229-7yoilsho	3520	6	was	be	VBD
cord-006229-7yoilsho	3520	7	separated	separate	VBN
cord-006229-7yoilsho	3520	8	by	by	IN
cord-006229-7yoilsho	3520	9	2-D	2-d	JJ
cord-006229-7yoilsho	3520	10	gel	gel	NN
cord-006229-7yoilsho	3520	11	electrophoresis	electrophoresis	NN
cord-006229-7yoilsho	3520	12	and	and	CC
cord-006229-7yoilsho	3520	13	differentially	differentially	RB
cord-006229-7yoilsho	3520	14	expressed	express	VBN
cord-006229-7yoilsho	3520	15	spots	spot	NNS
cord-006229-7yoilsho	3520	16	were	be	VBD
cord-006229-7yoilsho	3520	17	identified	identify	VBN
cord-006229-7yoilsho	3520	18	by	by	IN
cord-006229-7yoilsho	3520	19	MALDI	MALDI	NNP
cord-006229-7yoilsho	3520	20	-	-	HYPH
cord-006229-7yoilsho	3520	21	MS	MS	NNP
cord-006229-7yoilsho	3520	22	.	.	.
cord-006229-7yoilsho	3521	1	374	374	CD
cord-006229-7yoilsho	3521	2	unique	unique	JJ
cord-006229-7yoilsho	3521	3	proteins	protein	NNS
cord-006229-7yoilsho	3521	4	,	,	,
cord-006229-7yoilsho	3521	5	showing	show	VBG
cord-006229-7yoilsho	3521	6	a	a	DT
cord-006229-7yoilsho	3521	7	log	log	NN
cord-006229-7yoilsho	3521	8	2	2	CD
cord-006229-7yoilsho	3521	9	ratio	ratio	NN
cord-006229-7yoilsho	3521	10	of	of	IN
cord-006229-7yoilsho	3521	11	≤	≤	NN
cord-006229-7yoilsho	3521	12	-0.3	-0.3	:
cord-006229-7yoilsho	3521	13	for	for	IN
cord-006229-7yoilsho	3521	14	downregulation	downregulation	NN
cord-006229-7yoilsho	3521	15	and	and	CC
cord-006229-7yoilsho	3521	16	≥	≥	CD
cord-006229-7yoilsho	3521	17	0.3	0.3	CD
cord-006229-7yoilsho	3521	18	for	for	IN
cord-006229-7yoilsho	3521	19	upregulation	upregulation	NN
cord-006229-7yoilsho	3521	20	were	be	VBD
cord-006229-7yoilsho	3521	21	identified	identify	VBN
cord-006229-7yoilsho	3521	22	in	in	IN
cord-006229-7yoilsho	3521	23	all	all	DT
cord-006229-7yoilsho	3521	24	treatment	treatment	NN
cord-006229-7yoilsho	3521	25	groups	group	NNS
cord-006229-7yoilsho	3521	26	.	.	.
cord-006229-7yoilsho	3522	1	Protein	protein	NN
cord-006229-7yoilsho	3522	2	lists	list	NNS
cord-006229-7yoilsho	3522	3	were	be	VBD
cord-006229-7yoilsho	3522	4	analyzed	analyze	VBN
cord-006229-7yoilsho	3522	5	with	with	IN
cord-006229-7yoilsho	3522	6	Ingenuity	Ingenuity	NNP
cord-006229-7yoilsho	3522	7	Pathway	Pathway	NNP
cord-006229-7yoilsho	3522	8	Analysis	Analysis	NNP
cord-006229-7yoilsho	3522	9	(	(	-LRB-
cord-006229-7yoilsho	3522	10	IPA	IPA	NNP
cord-006229-7yoilsho	3522	11	)	)	-RRB-
cord-006229-7yoilsho	3522	12	.	.	.
cord-006229-7yoilsho	3523	1	When	when	WRB
cord-006229-7yoilsho	3523	2	comparing	compare	VBG
cord-006229-7yoilsho	3523	3	effects	effect	NNS
cord-006229-7yoilsho	3523	4	of	of	IN
cord-006229-7yoilsho	3523	5	particulate	particulate	NN
cord-006229-7yoilsho	3523	6	and	and	CC
cord-006229-7yoilsho	3523	7	ionic	ionic	JJ
cord-006229-7yoilsho	3523	8	treatments	treatment	NNS
cord-006229-7yoilsho	3523	9	,	,	,
cord-006229-7yoilsho	3523	10	similar	similar	JJ
cord-006229-7yoilsho	3523	11	alterations	alteration	NNS
cord-006229-7yoilsho	3523	12	were	be	VBD
cord-006229-7yoilsho	3523	13	indicated	indicate	VBN
cord-006229-7yoilsho	3523	14	for	for	IN
cord-006229-7yoilsho	3523	15	canonical	canonical	JJ
cord-006229-7yoilsho	3523	16	pathways	pathway	NNS
cord-006229-7yoilsho	3523	17	associated	associate	VBN
cord-006229-7yoilsho	3523	18	with	with	IN
cord-006229-7yoilsho	3523	19	glycolysis	glycolysis	NN
cord-006229-7yoilsho	3523	20	,	,	,
cord-006229-7yoilsho	3523	21	gluconeogenesis	gluconeogenesis	NN
cord-006229-7yoilsho	3523	22	and	and	CC
cord-006229-7yoilsho	3523	23	tricarboxylic	tricarboxylic	JJ
cord-006229-7yoilsho	3523	24	acid	acid	NN
cord-006229-7yoilsho	3523	25	cycle	cycle	NN
cord-006229-7yoilsho	3523	26	.	.	.
cord-006229-7yoilsho	3524	1	Regarding	regard	VBG
cord-006229-7yoilsho	3524	2	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	3524	3	responses	response	NNS
cord-006229-7yoilsho	3524	4	,	,	,
cord-006229-7yoilsho	3524	5	stronger	strong	JJR
cord-006229-7yoilsho	3524	6	effects	effect	NNS
cord-006229-7yoilsho	3524	7	were	be	VBD
cord-006229-7yoilsho	3524	8	derived	derive	VBN
cord-006229-7yoilsho	3524	9	for	for	IN
cord-006229-7yoilsho	3524	10	ionic	ionic	JJ
cord-006229-7yoilsho	3524	11	treatments	treatment	NNS
cord-006229-7yoilsho	3524	12	.	.	.
cord-006229-7yoilsho	3525	1	For	for	IN
cord-006229-7yoilsho	3525	2	both	both	DT
cord-006229-7yoilsho	3525	3	types	type	NNS
cord-006229-7yoilsho	3525	4	of	of	IN
cord-006229-7yoilsho	3525	5	silver	silver	JJ
cord-006229-7yoilsho	3525	6	exposures	exposure	NNS
cord-006229-7yoilsho	3525	7	,	,	,
cord-006229-7yoilsho	3525	8	changes	change	NNS
cord-006229-7yoilsho	3525	9	of	of	IN
cord-006229-7yoilsho	3525	10	protein	protein	NN
cord-006229-7yoilsho	3525	11	expressions	expression	NNS
cord-006229-7yoilsho	3525	12	were	be	VBD
cord-006229-7yoilsho	3525	13	linked	link	VBN
cord-006229-7yoilsho	3525	14	to	to	IN
cord-006229-7yoilsho	3525	15	changes	change	NNS
cord-006229-7yoilsho	3525	16	of	of	IN
cord-006229-7yoilsho	3525	17	fatty	fatty	JJ
cord-006229-7yoilsho	3525	18	acid	acid	NN
cord-006229-7yoilsho	3525	19	metabolism	metabolism	NN
cord-006229-7yoilsho	3525	20	and	and	CC
cord-006229-7yoilsho	3525	21	NRF2-mediated	nrf2-mediated	JJ
cord-006229-7yoilsho	3525	22	stress	stress	NN
cord-006229-7yoilsho	3525	23	.	.	.
cord-006229-7yoilsho	3526	1	Mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	3526	2	dysfunction	dysfunction	NN
cord-006229-7yoilsho	3526	3	was	be	VBD
cord-006229-7yoilsho	3526	4	highlighted	highlight	VBN
cord-006229-7yoilsho	3526	5	for	for	IN
cord-006229-7yoilsho	3526	6	both	both	DT
cord-006229-7yoilsho	3526	7	nanosilver	nanosilver	NNS
cord-006229-7yoilsho	3526	8	treatments	treatment	NNS
cord-006229-7yoilsho	3526	9	only	only	RB
cord-006229-7yoilsho	3526	10	,	,	,
cord-006229-7yoilsho	3526	11	as	as	RB
cord-006229-7yoilsho	3526	12	well	well	RB
cord-006229-7yoilsho	3526	13	as	as	IN
cord-006229-7yoilsho	3526	14	activation	activation	NN
cord-006229-7yoilsho	3526	15	of	of	IN
cord-006229-7yoilsho	3526	16	the	the	DT
cord-006229-7yoilsho	3526	17	insulin	insulin	NN
cord-006229-7yoilsho	3526	18	receptor	receptor	NN
cord-006229-7yoilsho	3526	19	.	.	.
cord-006229-7yoilsho	3527	1	In	in	IN
cord-006229-7yoilsho	3527	2	the	the	DT
cord-006229-7yoilsho	3527	3	top	top	RB
cord-006229-7yoilsho	3527	4	-	-	HYPH
cord-006229-7yoilsho	3527	5	scored	score	VBN
cord-006229-7yoilsho	3527	6	network	network	NN
cord-006229-7yoilsho	3527	7	of	of	IN
cord-006229-7yoilsho	3527	8	the	the	DT
cord-006229-7yoilsho	3527	9	higher	high	JJR
cord-006229-7yoilsho	3527	10	dose	dose	NN
cord-006229-7yoilsho	3527	11	nanosilver	nanosilver	NN
cord-006229-7yoilsho	3527	12	treatment	treatment	NN
cord-006229-7yoilsho	3527	13	,	,	,
cord-006229-7yoilsho	3527	14	upregulated	upregulate	VBN
cord-006229-7yoilsho	3527	15	14	14	CD
cord-006229-7yoilsho	3527	16	-	-	SYM
cord-006229-7yoilsho	3527	17	3	3	CD
cord-006229-7yoilsho	3527	18	-	-	SYM
cord-006229-7yoilsho	3527	19	3	3	CD
cord-006229-7yoilsho	3527	20	protein	protein	NN
cord-006229-7yoilsho	3527	21	zeta	zeta	NN
cord-006229-7yoilsho	3527	22	(	(	-LRB-
cord-006229-7yoilsho	3527	23	YWHAZ	YWHAZ	NNP
cord-006229-7yoilsho	3527	24	)	)	-RRB-
cord-006229-7yoilsho	3527	25	displays	display	VBZ
cord-006229-7yoilsho	3527	26	a	a	DT
cord-006229-7yoilsho	3527	27	central	central	JJ
cord-006229-7yoilsho	3527	28	position	position	NN
cord-006229-7yoilsho	3527	29	.	.	.
cord-006229-7yoilsho	3528	1	YWHAZ	YWHAZ	NNP
cord-006229-7yoilsho	3528	2	,	,	,
cord-006229-7yoilsho	3528	3	an	an	DT
cord-006229-7yoilsho	3528	4	important	important	JJ
cord-006229-7yoilsho	3528	5	regulator	regulator	NN
cord-006229-7yoilsho	3528	6	of	of	IN
cord-006229-7yoilsho	3528	7	cell	cell	NN
cord-006229-7yoilsho	3528	8	cycle	cycle	NN
cord-006229-7yoilsho	3528	9	and	and	CC
cord-006229-7yoilsho	3528	10	apoptosis	apoptosis	NN
cord-006229-7yoilsho	3528	11	,	,	,
cord-006229-7yoilsho	3528	12	interacts	interact	VBZ
cord-006229-7yoilsho	3528	13	with	with	IN
cord-006229-7yoilsho	3528	14	the	the	DT
cord-006229-7yoilsho	3528	15	insulin	insulin	NN
cord-006229-7yoilsho	3528	16	receptor	receptor	NN
cord-006229-7yoilsho	3528	17	and	and	CC
cord-006229-7yoilsho	3528	18	is	be	VBZ
cord-006229-7yoilsho	3528	19	well	well	RB
cord-006229-7yoilsho	3528	20	known	known	JJ
cord-006229-7yoilsho	3528	21	to	to	TO
cord-006229-7yoilsho	3528	22	be	be	VB
cord-006229-7yoilsho	3528	23	envolved	envolve	VBN
cord-006229-7yoilsho	3528	24	in	in	IN
cord-006229-7yoilsho	3528	25	many	many	JJ
cord-006229-7yoilsho	3528	26	types	type	NNS
cord-006229-7yoilsho	3528	27	of	of	IN
cord-006229-7yoilsho	3528	28	cancer	cancer	NN
cord-006229-7yoilsho	3528	29	.	.	.
cord-006229-7yoilsho	3529	1	Overall	overall	RB
cord-006229-7yoilsho	3529	2	,	,	,
cord-006229-7yoilsho	3529	3	both	both	DT
cord-006229-7yoilsho	3529	4	forms	form	NNS
cord-006229-7yoilsho	3529	5	of	of	IN
cord-006229-7yoilsho	3529	6	silver	silver	JJ
cord-006229-7yoilsho	3529	7	treatment	treatment	NN
cord-006229-7yoilsho	3529	8	revealed	reveal	VBD
cord-006229-7yoilsho	3529	9	similar	similar	JJ
cord-006229-7yoilsho	3529	10	patterns	pattern	NNS
cord-006229-7yoilsho	3529	11	of	of	IN
cord-006229-7yoilsho	3529	12	affected	affect	VBN
cord-006229-7yoilsho	3529	13	cellular	cellular	JJ
cord-006229-7yoilsho	3529	14	and	and	CC
cord-006229-7yoilsho	3529	15	molecular	molecular	JJ
cord-006229-7yoilsho	3529	16	functions	function	NNS
cord-006229-7yoilsho	3529	17	in	in	IN
cord-006229-7yoilsho	3529	18	rat	rat	NN
cord-006229-7yoilsho	3529	19	kidney	kidney	NN
cord-006229-7yoilsho	3529	20	,	,	,
cord-006229-7yoilsho	3529	21	supporting	support	VBG
cord-006229-7yoilsho	3529	22	common	common	JJ
cord-006229-7yoilsho	3529	23	and	and	CC
cord-006229-7yoilsho	3529	24	overlapping	overlapping	JJ
cord-006229-7yoilsho	3529	25	mechanisms	mechanism	NNS
cord-006229-7yoilsho	3529	26	of	of	IN
cord-006229-7yoilsho	3529	27	particulate	particulate	NN
cord-006229-7yoilsho	3529	28	compared	compare	VBN
cord-006229-7yoilsho	3529	29	to	to	IN
cord-006229-7yoilsho	3529	30	ionic	ionic	JJ
cord-006229-7yoilsho	3529	31	silver	silver	NN
cord-006229-7yoilsho	3529	32	.	.	.
cord-006229-7yoilsho	3530	1	Because	because	IN
cord-006229-7yoilsho	3530	2	of	of	IN
cord-006229-7yoilsho	3530	3	the	the	DT
cord-006229-7yoilsho	3530	4	widespread	widespread	JJ
cord-006229-7yoilsho	3530	5	application	application	NN
cord-006229-7yoilsho	3530	6	of	of	IN
cord-006229-7yoilsho	3530	7	nanomaterials	nanomaterial	NNS
cord-006229-7yoilsho	3530	8	and	and	CC
cord-006229-7yoilsho	3530	9	the	the	DT
cord-006229-7yoilsho	3530	10	fact	fact	NN
cord-006229-7yoilsho	3530	11	that	that	IN
cord-006229-7yoilsho	3530	12	for	for	IN
cord-006229-7yoilsho	3530	13	some	some	DT
cord-006229-7yoilsho	3530	14	nanomaterials	nanomaterial	NNS
cord-006229-7yoilsho	3530	15	effects	effect	NNS
cord-006229-7yoilsho	3530	16	on	on	IN
cord-006229-7yoilsho	3530	17	different	different	JJ
cord-006229-7yoilsho	3530	18	organisms	organism	NNS
cord-006229-7yoilsho	3530	19	where	where	WRB
cord-006229-7yoilsho	3530	20	shown	show	VBN
cord-006229-7yoilsho	3530	21	,	,	,
cord-006229-7yoilsho	3530	22	nanomaterials	nanomaterial	NNS
cord-006229-7yoilsho	3530	23	are	be	VBP
cord-006229-7yoilsho	3530	24	still	still	RB
cord-006229-7yoilsho	3530	25	in	in	IN
cord-006229-7yoilsho	3530	26	focus	focus	NN
cord-006229-7yoilsho	3530	27	of	of	IN
cord-006229-7yoilsho	3530	28	interest	interest	NN
cord-006229-7yoilsho	3530	29	.	.	.
cord-006229-7yoilsho	3531	1	Moreover	moreover	RB
cord-006229-7yoilsho	3531	2	the	the	DT
cord-006229-7yoilsho	3531	3	fate	fate	NN
cord-006229-7yoilsho	3531	4	of	of	IN
cord-006229-7yoilsho	3531	5	NPs	NPs	NNP
cord-006229-7yoilsho	3531	6	is	be	VBZ
cord-006229-7yoilsho	3531	7	only	only	RB
cord-006229-7yoilsho	3531	8	partiallyassessed	partiallyassesse	VBN
cord-006229-7yoilsho	3531	9	over	over	IN
cord-006229-7yoilsho	3531	10	the	the	DT
cord-006229-7yoilsho	3531	11	lifecycle	lifecycle	NN
cord-006229-7yoilsho	3531	12	of	of	IN
cord-006229-7yoilsho	3531	13	products	product	NNS
cord-006229-7yoilsho	3531	14	containing	contain	VBG
cord-006229-7yoilsho	3531	15	nanomaterials	nanomaterial	NNS
cord-006229-7yoilsho	3531	16	.	.	.
cord-006229-7yoilsho	3532	1	While	while	IN
cord-006229-7yoilsho	3532	2	general	general	JJ
cord-006229-7yoilsho	3532	3	toxicological	toxicological	JJ
cord-006229-7yoilsho	3532	4	properties	property	NNS
cord-006229-7yoilsho	3532	5	of	of	IN
cord-006229-7yoilsho	3532	6	NPs	NPs	NNPS
cord-006229-7yoilsho	3532	7	are	be	VBP
cord-006229-7yoilsho	3532	8	well	well	RB
cord-006229-7yoilsho	3532	9	described	describe	VBN
cord-006229-7yoilsho	3532	10	in	in	IN
cord-006229-7yoilsho	3532	11	diverse	diverse	JJ
cord-006229-7yoilsho	3532	12	in	in	NN
cord-006229-7yoilsho	3532	13	-	-	HYPH
cord-006229-7yoilsho	3532	14	vitro	vitro	FW
cord-006229-7yoilsho	3532	15	and	and	CC
cord-006229-7yoilsho	3532	16	in	in	IN
cord-006229-7yoilsho	3532	17	-	-	HYPH
cord-006229-7yoilsho	3532	18	vivo	vivo	NN
cord-006229-7yoilsho	3532	19	experiments	experiment	NNS
cord-006229-7yoilsho	3532	20	,	,	,
cord-006229-7yoilsho	3532	21	the	the	DT
cord-006229-7yoilsho	3532	22	distribution	distribution	NN
cord-006229-7yoilsho	3532	23	of	of	IN
cord-006229-7yoilsho	3532	24	these	these	DT
cord-006229-7yoilsho	3532	25	particles	particle	NNS
cord-006229-7yoilsho	3532	26	during	during	IN
cord-006229-7yoilsho	3532	27	the	the	DT
cord-006229-7yoilsho	3532	28	whole	whole	JJ
cord-006229-7yoilsho	3532	29	and	and	CC
cord-006229-7yoilsho	3532	30	complex	complex	JJ
cord-006229-7yoilsho	3532	31	process	process	NN
cord-006229-7yoilsho	3532	32	of	of	IN
cord-006229-7yoilsho	3532	33	waste	waste	NN
cord-006229-7yoilsho	3532	34	incineration	incineration	NN
cord-006229-7yoilsho	3532	35	shows	show	VBZ
cord-006229-7yoilsho	3532	36	big	big	JJ
cord-006229-7yoilsho	3532	37	knowledge	knowledge	NN
cord-006229-7yoilsho	3532	38	gaps	gap	NNS
cord-006229-7yoilsho	3532	39	.	.	.
cord-006229-7yoilsho	3533	1	In	in	IN
cord-006229-7yoilsho	3533	2	the	the	DT
cord-006229-7yoilsho	3533	3	"	"	``
cord-006229-7yoilsho	3533	4	NanoEmission"-Project	NanoEmission"-Project	NNP
cord-006229-7yoilsho	3533	5	the	the	DT
cord-006229-7yoilsho	3533	6	entire	entire	JJ
cord-006229-7yoilsho	3533	7	route	route	NN
cord-006229-7yoilsho	3533	8	from	from	IN
cord-006229-7yoilsho	3533	9	the	the	DT
cord-006229-7yoilsho	3533	10	residual	residual	JJ
cord-006229-7yoilsho	3533	11	material	material	NN
cord-006229-7yoilsho	3533	12	via	via	IN
cord-006229-7yoilsho	3533	13	incineration	incineration	NN
cord-006229-7yoilsho	3533	14	,	,	,
cord-006229-7yoilsho	3533	15	filtering	filter	VBG
cord-006229-7yoilsho	3533	16	of	of	IN
cord-006229-7yoilsho	3533	17	the	the	DT
cord-006229-7yoilsho	3533	18	exhaust	exhaust	NN
cord-006229-7yoilsho	3533	19	gas	gas	NN
cord-006229-7yoilsho	3533	20	up	up	IN
cord-006229-7yoilsho	3533	21	to	to	IN
cord-006229-7yoilsho	3533	22	a	a	DT
cord-006229-7yoilsho	3533	23	possible	possible	JJ
cord-006229-7yoilsho	3533	24	release	release	NN
cord-006229-7yoilsho	3533	25	into	into	IN
cord-006229-7yoilsho	3533	26	the	the	DT
cord-006229-7yoilsho	3533	27	environment	environment	NN
cord-006229-7yoilsho	3533	28	are	be	VBP
cord-006229-7yoilsho	3533	29	considered	consider	VBN
cord-006229-7yoilsho	3533	30	together	together	RB
cord-006229-7yoilsho	3533	31	with	with	IN
cord-006229-7yoilsho	3533	32	the	the	DT
cord-006229-7yoilsho	3533	33	toxicological	toxicological	JJ
cord-006229-7yoilsho	3533	34	evaluation	evaluation	NN
cord-006229-7yoilsho	3533	35	of	of	IN
cord-006229-7yoilsho	3533	36	effects	effect	NNS
cord-006229-7yoilsho	3533	37	on	on	IN
cord-006229-7yoilsho	3533	38	humans	human	NNS
cord-006229-7yoilsho	3533	39	and	and	CC
cord-006229-7yoilsho	3533	40	the	the	DT
cord-006229-7yoilsho	3533	41	environment	environment	NN
cord-006229-7yoilsho	3533	42	.	.	.
cord-006229-7yoilsho	3534	1	In	in	IN
cord-006229-7yoilsho	3534	2	these	these	DT
cord-006229-7yoilsho	3534	3	experiments	experiment	NNS
cord-006229-7yoilsho	3534	4	the	the	DT
cord-006229-7yoilsho	3534	5	influence	influence	NN
cord-006229-7yoilsho	3534	6	of	of	IN
cord-006229-7yoilsho	3534	7	thermal	thermal	JJ
cord-006229-7yoilsho	3534	8	waste	waste	NN
cord-006229-7yoilsho	3534	9	treatment	treatment	NN
cord-006229-7yoilsho	3534	10	on	on	IN
cord-006229-7yoilsho	3534	11	the	the	DT
cord-006229-7yoilsho	3534	12	toxicological	toxicological	JJ
cord-006229-7yoilsho	3534	13	profile	profile	NN
cord-006229-7yoilsho	3534	14	of	of	IN
cord-006229-7yoilsho	3534	15	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	3534	16	,	,	,
cord-006229-7yoilsho	3534	17	contained	contain	VBN
cord-006229-7yoilsho	3534	18	in	in	IN
cord-006229-7yoilsho	3534	19	the	the	DT
cord-006229-7yoilsho	3534	20	waste	waste	NN
cord-006229-7yoilsho	3534	21	,	,	,
cord-006229-7yoilsho	3534	22	will	will	MD
cord-006229-7yoilsho	3534	23	be	be	VB
cord-006229-7yoilsho	3534	24	described	describe	VBN
cord-006229-7yoilsho	3534	25	.	.	.
cord-006229-7yoilsho	3535	1	After	after	IN
cord-006229-7yoilsho	3535	2	a	a	DT
cord-006229-7yoilsho	3535	3	complete	complete	JJ
cord-006229-7yoilsho	3535	4	characterization	characterization	NN
cord-006229-7yoilsho	3535	5	of	of	IN
cord-006229-7yoilsho	3535	6	the	the	DT
cord-006229-7yoilsho	3535	7	two	two	CD
cord-006229-7yoilsho	3535	8	types	type	NNS
cord-006229-7yoilsho	3535	9	of	of	IN
cord-006229-7yoilsho	3535	10	BaSO	BaSO	NNP
cord-006229-7yoilsho	3535	11	4	4	CD
cord-006229-7yoilsho	3535	12	-NPs	-NPs	:
cord-006229-7yoilsho	3535	13	from	from	IN
cord-006229-7yoilsho	3535	14	two	two	CD
cord-006229-7yoilsho	3535	15	different	different	JJ
cord-006229-7yoilsho	3535	16	manufacturers	manufacturer	NNS
cord-006229-7yoilsho	3535	17	by	by	IN
cord-006229-7yoilsho	3535	18	scanning	scan	VBG
cord-006229-7yoilsho	3535	19	electron	electron	NN
cord-006229-7yoilsho	3535	20	microscopy/	microscopy/	CD
cord-006229-7yoilsho	3535	21	energy	energy	NN
cord-006229-7yoilsho	3535	22	dispersive	dispersive	NNP
cord-006229-7yoilsho	3535	23	X	X	NNP
cord-006229-7yoilsho	3535	24	-	-	NN
cord-006229-7yoilsho	3535	25	ray	ray	NN
cord-006229-7yoilsho	3535	26	analysis	analysis	NN
cord-006229-7yoilsho	3535	27	(	(	-LRB-
cord-006229-7yoilsho	3535	28	SEM	SEM	NNP
cord-006229-7yoilsho	3535	29	/	/	SYM
cord-006229-7yoilsho	3535	30	EDX	EDX	NNP
cord-006229-7yoilsho	3535	31	)	)	-RRB-
cord-006229-7yoilsho	3535	32	,	,	,
cord-006229-7yoilsho	3535	33	measurement	measurement	NN
cord-006229-7yoilsho	3535	34	of	of	IN
cord-006229-7yoilsho	3535	35	the	the	DT
cord-006229-7yoilsho	3535	36	specific	specific	JJ
cord-006229-7yoilsho	3535	37	surface	surface	NN
cord-006229-7yoilsho	3535	38	area	area	NN
cord-006229-7yoilsho	3535	39	(	(	-LRB-
cord-006229-7yoilsho	3535	40	BET	bet	RB
cord-006229-7yoilsho	3535	41	)	)	-RRB-
cord-006229-7yoilsho	3535	42	and	and	CC
cord-006229-7yoilsho	3535	43	dynamic	dynamic	JJ
cord-006229-7yoilsho	3535	44	light	light	JJ
cord-006229-7yoilsho	3535	45	scattering	scattering	NN
cord-006229-7yoilsho	3535	46	(	(	-LRB-
cord-006229-7yoilsho	3535	47	DLS	DLS	NNP
cord-006229-7yoilsho	3535	48	)	)	-RRB-
cord-006229-7yoilsho	3535	49	we	-PRON-	PRP
cord-006229-7yoilsho	3535	50	investigated	investigate	VBD
cord-006229-7yoilsho	3535	51	the	the	DT
cord-006229-7yoilsho	3535	52	impact	impact	NN
cord-006229-7yoilsho	3535	53	of	of	IN
cord-006229-7yoilsho	3535	54	the	the	DT
cord-006229-7yoilsho	3535	55	pure	pure	JJ
cord-006229-7yoilsho	3535	56	BaSO	BaSO	NNP
cord-006229-7yoilsho	3535	57	4	4	CD
cord-006229-7yoilsho	3535	58	-NPs	-nps	RB
cord-006229-7yoilsho	3535	59	on	on	IN
cord-006229-7yoilsho	3535	60	primary	primary	JJ
cord-006229-7yoilsho	3535	61	cells	cell	NNS
cord-006229-7yoilsho	3535	62	(	(	-LRB-
cord-006229-7yoilsho	3535	63	normal	normal	JJ
cord-006229-7yoilsho	3535	64	human	human	JJ
cord-006229-7yoilsho	3535	65	bronchial	bronchial	JJ
cord-006229-7yoilsho	3535	66	epithelial	epithelial	JJ
cord-006229-7yoilsho	3535	67	cells	cell	NNS
cord-006229-7yoilsho	3535	68	(	(	-LRB-
cord-006229-7yoilsho	3535	69	NHBEC	NHBEC	NNP
cord-006229-7yoilsho	3535	70	)	)	-RRB-
cord-006229-7yoilsho	3535	71	and	and	CC
cord-006229-7yoilsho	3535	72	peripherial	peripherial	JJ
cord-006229-7yoilsho	3535	73	lung	lung	NN
cord-006229-7yoilsho	3535	74	cells	cell	NNS
cord-006229-7yoilsho	3535	75	(	(	-LRB-
cord-006229-7yoilsho	3535	76	PLC	PLC	NNP
cord-006229-7yoilsho	3535	77	)	)	-RRB-
cord-006229-7yoilsho	3535	78	)	)	-RRB-
cord-006229-7yoilsho	3535	79	.	.	.
cord-006229-7yoilsho	3536	1	Both	both	DT
cord-006229-7yoilsho	3536	2	materials	material	NNS
cord-006229-7yoilsho	3536	3	show	show	VBP
cord-006229-7yoilsho	3536	4	statistically	statistically	RB
cord-006229-7yoilsho	3536	5	significant	significant	JJ
cord-006229-7yoilsho	3536	6	cytotoxic	cytotoxic	JJ
cord-006229-7yoilsho	3536	7	effects	effect	NNS
cord-006229-7yoilsho	3536	8	in	in	IN
cord-006229-7yoilsho	3536	9	the	the	DT
cord-006229-7yoilsho	3536	10	Resazurin	Resazurin	NNP
cord-006229-7yoilsho	3536	11	-	-	HYPH
cord-006229-7yoilsho	3536	12	Assay	Assay	NNP
cord-006229-7yoilsho	3536	13	(	(	-LRB-
cord-006229-7yoilsho	3536	14	decreased	decrease	VBD
cord-006229-7yoilsho	3536	15	viability	viability	NN
cord-006229-7yoilsho	3536	16	below	below	IN
cord-006229-7yoilsho	3536	17	40	40	CD
cord-006229-7yoilsho	3536	18	%	%	NN
cord-006229-7yoilsho	3536	19	for	for	IN
cord-006229-7yoilsho	3536	20	1	1	CD
cord-006229-7yoilsho	3536	21	mg	mg	NNP
cord-006229-7yoilsho	3536	22	/	/	SYM
cord-006229-7yoilsho	3536	23	ml	ml	NN
cord-006229-7yoilsho	3536	24	after	after	IN
cord-006229-7yoilsho	3536	25	72	72	CD
cord-006229-7yoilsho	3536	26	h	h	NN
cord-006229-7yoilsho	3536	27	)	)	-RRB-
cord-006229-7yoilsho	3536	28	.	.	.
cord-006229-7yoilsho	3537	1	In	in	IN
cord-006229-7yoilsho	3537	2	general	general	JJ
cord-006229-7yoilsho	3537	3	the	the	DT
cord-006229-7yoilsho	3537	4	effects	effect	NNS
cord-006229-7yoilsho	3537	5	of	of	IN
cord-006229-7yoilsho	3537	6	both	both	DT
cord-006229-7yoilsho	3537	7	NPs	NPs	NNPS
cord-006229-7yoilsho	3537	8	were	be	VBD
cord-006229-7yoilsho	3537	9	almost	almost	RB
cord-006229-7yoilsho	3537	10	similar	similar	JJ
cord-006229-7yoilsho	3537	11	.	.	.
cord-006229-7yoilsho	3538	1	Additionally	additionally	RB
cord-006229-7yoilsho	3538	2	the	the	DT
cord-006229-7yoilsho	3538	3	effects	effect	NNS
cord-006229-7yoilsho	3538	4	of	of	IN
cord-006229-7yoilsho	3538	5	the	the	DT
cord-006229-7yoilsho	3538	6	BaSO	BaSO	NNP
cord-006229-7yoilsho	3538	7	4-NPs	4-nps	CD
cord-006229-7yoilsho	3538	8	were	be	VBD
cord-006229-7yoilsho	3538	9	compared	compare	VBN
cord-006229-7yoilsho	3538	10	more	more	RBR
cord-006229-7yoilsho	3538	11	in	in	IN
cord-006229-7yoilsho	3538	12	detail	detail	NN
cord-006229-7yoilsho	3538	13	.	.	.
cord-006229-7yoilsho	3539	1	Uptake	uptake	NN
cord-006229-7yoilsho	3539	2	of	of	IN
cord-006229-7yoilsho	3539	3	the	the	DT
cord-006229-7yoilsho	3539	4	BaSO	BaSO	NNP
cord-006229-7yoilsho	3539	5	4	4	CD
cord-006229-7yoilsho	3539	6	was	be	VBD
cord-006229-7yoilsho	3539	7	quantified	quantify	VBN
cord-006229-7yoilsho	3539	8	by	by	IN
cord-006229-7yoilsho	3539	9	ICP	ICP	NNP
cord-006229-7yoilsho	3539	10	-	-	HYPH
cord-006229-7yoilsho	3539	11	MS	MS	NNP
cord-006229-7yoilsho	3539	12	after	after	IN
cord-006229-7yoilsho	3539	13	24	24	CD
cord-006229-7yoilsho	3539	14	h	h	NN
cord-006229-7yoilsho	3539	15	and	and	CC
cord-006229-7yoilsho	3539	16	72	72	CD
cord-006229-7yoilsho	3539	17	h	h	NN
cord-006229-7yoilsho	3539	18	as	as	RB
cord-006229-7yoilsho	3539	19	well	well	RB
cord-006229-7yoilsho	3539	20	as	as	IN
cord-006229-7yoilsho	3539	21	the	the	DT
cord-006229-7yoilsho	3539	22	release	release	NN
cord-006229-7yoilsho	3539	23	of	of	IN
cord-006229-7yoilsho	3539	24	Ba	Ba	NNP
cord-006229-7yoilsho	3539	25	-	-	HYPH
cord-006229-7yoilsho	3539	26	ions	ion	NNS
cord-006229-7yoilsho	3539	27	into	into	IN
cord-006229-7yoilsho	3539	28	the	the	DT
cord-006229-7yoilsho	3539	29	cell	cell	NN
cord-006229-7yoilsho	3539	30	culture	culture	NN
cord-006229-7yoilsho	3539	31	medium	medium	NN
cord-006229-7yoilsho	3539	32	after	after	IN
cord-006229-7yoilsho	3539	33	centrifugal	centrifugal	JJ
cord-006229-7yoilsho	3539	34	separation	separation	NN
cord-006229-7yoilsho	3539	35	.	.	.
cord-006229-7yoilsho	3540	1	The	the	DT
cord-006229-7yoilsho	3540	2	incubation	incubation	NN
cord-006229-7yoilsho	3540	3	with	with	IN
cord-006229-7yoilsho	3540	4	BaSO	BaSO	NNP
cord-006229-7yoilsho	3540	5	4	4	CD
cord-006229-7yoilsho	3540	6	of	of	IN
cord-006229-7yoilsho	3540	7	PLC	PLC	NNP
cord-006229-7yoilsho	3540	8	and	and	CC
cord-006229-7yoilsho	3540	9	NHBEC	NHBEC	NNP
cord-006229-7yoilsho	3540	10	to	to	IN
cord-006229-7yoilsho	3540	11	0.1	0.1	CD
cord-006229-7yoilsho	3540	12	mg	mg	NNP
cord-006229-7yoilsho	3540	13	/	/	SYM
cord-006229-7yoilsho	3540	14	ml	ml	NN
cord-006229-7yoilsho	3540	15	over	over	IN
cord-006229-7yoilsho	3540	16	24	24	CD
cord-006229-7yoilsho	3540	17	h	h	NN
cord-006229-7yoilsho	3540	18	and	and	CC
cord-006229-7yoilsho	3540	19	72	72	CD
cord-006229-7yoilsho	3540	20	h	h	NN
cord-006229-7yoilsho	3540	21	leads	lead	VBZ
cord-006229-7yoilsho	3540	22	to	to	IN
cord-006229-7yoilsho	3540	23	~200	~200	.
cord-006229-7yoilsho	3541	1	µg	µg	NNP
cord-006229-7yoilsho	3541	2	BaSO	BaSO	NNP
cord-006229-7yoilsho	3541	3	4	4	CD
cord-006229-7yoilsho	3541	4	/1	/1	.
cord-006229-7yoilsho	3542	1	mio	mio	NNP
cord-006229-7yoilsho	3542	2	cells	cell	NNS
cord-006229-7yoilsho	3542	3	.	.	.
cord-006229-7yoilsho	3543	1	The	the	DT
cord-006229-7yoilsho	3543	2	uptake	uptake	NN
cord-006229-7yoilsho	3543	3	is	be	VBZ
cord-006229-7yoilsho	3543	4	dose	dose	NN
cord-006229-7yoilsho	3543	5	dependent	dependent	JJ
cord-006229-7yoilsho	3543	6	but	but	CC
cord-006229-7yoilsho	3543	7	not	not	RB
cord-006229-7yoilsho	3543	8	time	time	NN
cord-006229-7yoilsho	3543	9	dependent	dependent	JJ
cord-006229-7yoilsho	3543	10	.	.	.
cord-006229-7yoilsho	3544	1	The	the	DT
cord-006229-7yoilsho	3544	2	impact	impact	NN
cord-006229-7yoilsho	3544	3	on	on	IN
cord-006229-7yoilsho	3544	4	the	the	DT
cord-006229-7yoilsho	3544	5	secretion	secretion	NN
cord-006229-7yoilsho	3544	6	of	of	IN
cord-006229-7yoilsho	3544	7	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	3544	8	cytokines	cytokine	NNS
cord-006229-7yoilsho	3544	9	was	be	VBD
cord-006229-7yoilsho	3544	10	determined	determine	VBN
cord-006229-7yoilsho	3544	11	by	by	IN
cord-006229-7yoilsho	3544	12	bead	bead	NN
cord-006229-7yoilsho	3544	13	-	-	HYPH
cord-006229-7yoilsho	3544	14	based	base	VBN
cord-006229-7yoilsho	3544	15	multiplex	multiplex	NN
cord-006229-7yoilsho	3544	16	-	-	HYPH
cord-006229-7yoilsho	3544	17	ELISA	elisa	NN
cord-006229-7yoilsho	3544	18	flow	flow	NN
cord-006229-7yoilsho	3544	19	cytometry	cytometry	NN
cord-006229-7yoilsho	3544	20	.	.	.
cord-006229-7yoilsho	3545	1	TNF	TNF	NNP
cord-006229-7yoilsho	3545	2	-	-	HYPH
cord-006229-7yoilsho	3545	3	α	α	NNP
cord-006229-7yoilsho	3545	4	,	,	,
cord-006229-7yoilsho	3545	5	IL-8	IL-8	NNP
cord-006229-7yoilsho	3545	6	and	and	CC
cord-006229-7yoilsho	3545	7	IL-33	IL-33	NNP
cord-006229-7yoilsho	3545	8	could	could	MD
cord-006229-7yoilsho	3545	9	be	be	VB
cord-006229-7yoilsho	3545	10	detected	detect	VBN
cord-006229-7yoilsho	3545	11	in	in	IN
cord-006229-7yoilsho	3545	12	NHBEC	NHBEC	NNP
cord-006229-7yoilsho	3545	13	and	and	CC
cord-006229-7yoilsho	3545	14	PLC	PLC	NNP
cord-006229-7yoilsho	3545	15	after	after	IN
cord-006229-7yoilsho	3545	16	NP	NP	NNP
cord-006229-7yoilsho	3545	17	incubation	incubation	NN
cord-006229-7yoilsho	3545	18	.	.	.
cord-006229-7yoilsho	3546	1	The	the	DT
cord-006229-7yoilsho	3546	2	possible	possible	JJ
cord-006229-7yoilsho	3546	3	induction	induction	NN
cord-006229-7yoilsho	3546	4	of	of	IN
cord-006229-7yoilsho	3546	5	apoptosis	apoptosis	NN
cord-006229-7yoilsho	3546	6	was	be	VBD
cord-006229-7yoilsho	3546	7	measured	measure	VBN
cord-006229-7yoilsho	3546	8	by	by	IN
cord-006229-7yoilsho	3546	9	flow	flow	NN
cord-006229-7yoilsho	3546	10	cytometry	cytometry	NN
cord-006229-7yoilsho	3546	11	as	as	RB
cord-006229-7yoilsho	3546	12	well	well	RB
cord-006229-7yoilsho	3546	13	.	.	.
cord-006229-7yoilsho	3547	1	First	first	JJ
cord-006229-7yoilsho	3547	2	investigations	investigation	NNS
cord-006229-7yoilsho	3547	3	showed	show	VBD
cord-006229-7yoilsho	3547	4	no	no	DT
cord-006229-7yoilsho	3547	5	induction	induction	NN
cord-006229-7yoilsho	3547	6	of	of	IN
cord-006229-7yoilsho	3547	7	apoptosis	apoptosis	NN
cord-006229-7yoilsho	3547	8	for	for	IN
cord-006229-7yoilsho	3547	9	both	both	DT
cord-006229-7yoilsho	3547	10	materials	material	NNS
cord-006229-7yoilsho	3547	11	.	.	.
cord-006229-7yoilsho	3548	1	The	the	DT
cord-006229-7yoilsho	3548	2	impact	impact	NN
cord-006229-7yoilsho	3548	3	of	of	IN
cord-006229-7yoilsho	3548	4	both	both	DT
cord-006229-7yoilsho	3548	5	NPs	NPs	NNPS
cord-006229-7yoilsho	3548	6	on	on	IN
cord-006229-7yoilsho	3548	7	the	the	DT
cord-006229-7yoilsho	3548	8	intracellular	intracellular	JJ
cord-006229-7yoilsho	3548	9	glutathione	glutathione	NN
cord-006229-7yoilsho	3548	10	level	level	NN
cord-006229-7yoilsho	3548	11	was	be	VBD
cord-006229-7yoilsho	3548	12	measured	measure	VBN
cord-006229-7yoilsho	3548	13	by	by	IN
cord-006229-7yoilsho	3548	14	HPLC	HPLC	NNP
cord-006229-7yoilsho	3548	15	and	and	CC
cord-006229-7yoilsho	3548	16	showed	show	VBD
cord-006229-7yoilsho	3548	17	a	a	DT
cord-006229-7yoilsho	3548	18	decrease	decrease	NN
cord-006229-7yoilsho	3548	19	of	of	IN
cord-006229-7yoilsho	3548	20	GSH	GSH	NNP
cord-006229-7yoilsho	3548	21	after	after	IN
cord-006229-7yoilsho	3548	22	72	72	CD
cord-006229-7yoilsho	3548	23	h.	h.	NN
cord-006229-7yoilsho	3548	24	Summing	sum	VBG
cord-006229-7yoilsho	3548	25	up	up	RP
cord-006229-7yoilsho	3548	26	BaSO	BaSO	NNP
cord-006229-7yoilsho	3548	27	4	4	CD
cord-006229-7yoilsho	3548	28	-NPs	-nps	CC
cord-006229-7yoilsho	3548	29	showed	show	VBD
cord-006229-7yoilsho	3548	30	toxic	toxic	JJ
cord-006229-7yoilsho	3548	31	effects	effect	NNS
cord-006229-7yoilsho	3548	32	in	in	IN
cord-006229-7yoilsho	3548	33	primary	primary	JJ
cord-006229-7yoilsho	3548	34	human	human	JJ
cord-006229-7yoilsho	3548	35	lung	lung	NN
cord-006229-7yoilsho	3548	36	cell	cell	NN
cord-006229-7yoilsho	3548	37	cultures	culture	NNS
cord-006229-7yoilsho	3548	38	after	after	IN
cord-006229-7yoilsho	3548	39	72	72	CD
cord-006229-7yoilsho	3548	40	h	h	NN
cord-006229-7yoilsho	3548	41	for	for	IN
cord-006229-7yoilsho	3548	42	concentrations	concentration	NNS
cord-006229-7yoilsho	3548	43	under	under	IN
cord-006229-7yoilsho	3548	44	1	1	CD
cord-006229-7yoilsho	3548	45	mg	mg	NNP
cord-006229-7yoilsho	3548	46	/	/	SYM
cord-006229-7yoilsho	3548	47	ml	ml	NN
cord-006229-7yoilsho	3548	48	.	.	.
cord-006229-7yoilsho	3549	1	C3	C3	NNP
cord-006229-7yoilsho	3549	2	exoenzyme	exoenzyme	NNS
cord-006229-7yoilsho	3549	3	from	from	IN
cord-006229-7yoilsho	3549	4	C.	C.	NNP
cord-006229-7yoilsho	3549	5	botulinum	botulinum	NN
cord-006229-7yoilsho	3549	6	is	be	VBZ
cord-006229-7yoilsho	3549	7	an	an	DT
cord-006229-7yoilsho	3549	8	ADP	ADP	NNP
cord-006229-7yoilsho	3549	9	-	-	HYPH
cord-006229-7yoilsho	3549	10	ribosyltransferase	ribosyltransferase	NN
cord-006229-7yoilsho	3549	11	that	that	WDT
cord-006229-7yoilsho	3549	12	inactivates	inactivate	VBZ
cord-006229-7yoilsho	3549	13	selectively	selectively	RB
cord-006229-7yoilsho	3549	14	RhoA	RhoA	NNP
cord-006229-7yoilsho	3549	15	,	,	,
cord-006229-7yoilsho	3549	16	B	B	NNP
cord-006229-7yoilsho	3549	17	and	and	CC
cord-006229-7yoilsho	3549	18	C	c	NN
cord-006229-7yoilsho	3549	19	by	by	IN
cord-006229-7yoilsho	3549	20	coupling	couple	VBG
cord-006229-7yoilsho	3549	21	an	an	DT
cord-006229-7yoilsho	3549	22	ADP	ADP	NNP
cord-006229-7yoilsho	3549	23	-	-	HYPH
cord-006229-7yoilsho	3549	24	ribose	ribose	NN
cord-006229-7yoilsho	3549	25	moiety	moiety	NN
cord-006229-7yoilsho	3549	26	.	.	.
cord-006229-7yoilsho	3550	1	Rho	rho	NN
cord-006229-7yoilsho	3550	2	-	-	HYPH
cord-006229-7yoilsho	3550	3	GTPases	gtpase	NNS
cord-006229-7yoilsho	3550	4	represent	represent	VBP
cord-006229-7yoilsho	3550	5	a	a	DT
cord-006229-7yoilsho	3550	6	molecular	molecular	JJ
cord-006229-7yoilsho	3550	7	switch	switch	NN
cord-006229-7yoilsho	3550	8	integrating	integrate	VBG
cord-006229-7yoilsho	3550	9	different	different	JJ
cord-006229-7yoilsho	3550	10	receptor	receptor	NN
cord-006229-7yoilsho	3550	11	signalling	signal	VBG
cord-006229-7yoilsho	3550	12	to	to	IN
cord-006229-7yoilsho	3550	13	downstream	downstream	JJ
cord-006229-7yoilsho	3550	14	transcriptional	transcriptional	JJ
cord-006229-7yoilsho	3550	15	cascades	cascade	NNS
cord-006229-7yoilsho	3550	16	that	that	WDT
cord-006229-7yoilsho	3550	17	regulate	regulate	VBP
cord-006229-7yoilsho	3550	18	various	various	JJ
cord-006229-7yoilsho	3550	19	cellular	cellular	JJ
cord-006229-7yoilsho	3550	20	processes	process	NNS
cord-006229-7yoilsho	3550	21	,	,	,
cord-006229-7yoilsho	3550	22	such	such	JJ
cord-006229-7yoilsho	3550	23	as	as	IN
cord-006229-7yoilsho	3550	24	regulation	regulation	NN
cord-006229-7yoilsho	3550	25	of	of	IN
cord-006229-7yoilsho	3550	26	actin	actin	NN
cord-006229-7yoilsho	3550	27	cytoskeleton	cytoskeleton	NN
cord-006229-7yoilsho	3550	28	,	,	,
cord-006229-7yoilsho	3550	29	cell	cell	NN
cord-006229-7yoilsho	3550	30	proliferation	proliferation	NN
cord-006229-7yoilsho	3550	31	and	and	CC
cord-006229-7yoilsho	3550	32	apoptosis	apoptosis	NN
cord-006229-7yoilsho	3550	33	.	.	.
cord-006229-7yoilsho	3551	1	Previous	previous	JJ
cord-006229-7yoilsho	3551	2	studies	study	NNS
cord-006229-7yoilsho	3551	3	with	with	IN
cord-006229-7yoilsho	3551	4	the	the	DT
cord-006229-7yoilsho	3551	5	murine	murine	JJ
cord-006229-7yoilsho	3551	6	hippocampal	hippocampal	JJ
cord-006229-7yoilsho	3551	7	cell	cell	NN
cord-006229-7yoilsho	3551	8	line	line	NN
cord-006229-7yoilsho	3551	9	HT22	HT22	NNP
cord-006229-7yoilsho	3551	10	revealed	reveal	VBD
cord-006229-7yoilsho	3551	11	a	a	DT
cord-006229-7yoilsho	3551	12	C3-mediated	c3-mediate	VBN
cord-006229-7yoilsho	3551	13	inhibition	inhibition	NN
cord-006229-7yoilsho	3551	14	of	of	IN
cord-006229-7yoilsho	3551	15	cell	cell	NN
cord-006229-7yoilsho	3551	16	proliferation	proliferation	NN
cord-006229-7yoilsho	3551	17	and	and	CC
cord-006229-7yoilsho	3551	18	a	a	DT
cord-006229-7yoilsho	3551	19	prevention	prevention	NN
cord-006229-7yoilsho	3551	20	of	of	IN
cord-006229-7yoilsho	3551	21	serum	serum	NN
cord-006229-7yoilsho	3551	22	-	-	HYPH
cord-006229-7yoilsho	3551	23	starved	starve	VBN
cord-006229-7yoilsho	3551	24	cells	cell	NNS
cord-006229-7yoilsho	3551	25	from	from	IN
cord-006229-7yoilsho	3551	26	apoptosis	apoptosis	NN
cord-006229-7yoilsho	3551	27	(	(	-LRB-
cord-006229-7yoilsho	3551	28	Rohrbeck	Rohrbeck	NNP
cord-006229-7yoilsho	3551	29	et	et	FW
cord-006229-7yoilsho	3551	30	al	al	NNP
cord-006229-7yoilsho	3551	31	.	.	NNP
cord-006229-7yoilsho	3551	32	,	,	,
cord-006229-7yoilsho	3551	33	2012	2012	CD
cord-006229-7yoilsho	3551	34	)	)	-RRB-
cord-006229-7yoilsho	3551	35	.	.	.
cord-006229-7yoilsho	3552	1	Former	former	JJ
cord-006229-7yoilsho	3552	2	results	result	NNS
cord-006229-7yoilsho	3552	3	of	of	IN
cord-006229-7yoilsho	3552	4	studies	study	NNS
cord-006229-7yoilsho	3552	5	on	on	IN
cord-006229-7yoilsho	3552	6	MAP	MAP	NNP
cord-006229-7yoilsho	3552	7	kinase	kinase	NN
cord-006229-7yoilsho	3552	8	signalling	signalling	NN
cord-006229-7yoilsho	3552	9	indicated	indicate	VBD
cord-006229-7yoilsho	3552	10	C3-induced	c3-induce	VBN
cord-006229-7yoilsho	3552	11	modulations	modulation	NNS
cord-006229-7yoilsho	3552	12	of	of	IN
cord-006229-7yoilsho	3552	13	downstream	downstream	JJ
cord-006229-7yoilsho	3552	14	signalling	signal	VBG
cord-006229-7yoilsho	3552	15	modules	module	NNS
cord-006229-7yoilsho	3552	16	.	.	.
cord-006229-7yoilsho	3553	1	Therefore	therefore	RB
cord-006229-7yoilsho	3553	2	,	,	,
cord-006229-7yoilsho	3553	3	HT22	HT22	NNP
cord-006229-7yoilsho	3553	4	cells	cell	NNS
cord-006229-7yoilsho	3553	5	treated	treat	VBN
cord-006229-7yoilsho	3553	6	with	with	IN
cord-006229-7yoilsho	3553	7	500	500	CD
cord-006229-7yoilsho	3553	8	nM	nm	CD
cord-006229-7yoilsho	3553	9	C3	C3	NNP
cord-006229-7yoilsho	3553	10	for	for	IN
cord-006229-7yoilsho	3553	11	48	48	CD
cord-006229-7yoilsho	3553	12	h	h	NNP
cord-006229-7yoilsho	3553	13	were	be	VBD
cord-006229-7yoilsho	3553	14	applied	apply	VBN
cord-006229-7yoilsho	3553	15	for	for	IN
cord-006229-7yoilsho	3553	16	screening	screening	NN
cord-006229-7yoilsho	3553	17	of	of	IN
cord-006229-7yoilsho	3553	18	the	the	DT
cord-006229-7yoilsho	3553	19	activity	activity	NN
cord-006229-7yoilsho	3553	20	of	of	IN
cord-006229-7yoilsho	3553	21	48	48	CD
cord-006229-7yoilsho	3553	22	various	various	JJ
cord-006229-7yoilsho	3553	23	transcription	transcription	NN
cord-006229-7yoilsho	3553	24	factors	factor	NNS
cord-006229-7yoilsho	3553	25	followed	follow	VBN
cord-006229-7yoilsho	3553	26	by	by	IN
cord-006229-7yoilsho	3553	27	Luciferase	Luciferase	NNP
cord-006229-7yoilsho	3553	28	reporter	reporter	NN
cord-006229-7yoilsho	3553	29	assays	assay	NNS
cord-006229-7yoilsho	3553	30	.	.	.
cord-006229-7yoilsho	3554	1	Five	five	CD
cord-006229-7yoilsho	3554	2	transcription	transcription	NN
cord-006229-7yoilsho	3554	3	factors	factor	NNS
cord-006229-7yoilsho	3554	4	namely	namely	RB
cord-006229-7yoilsho	3554	5	Sp1	Sp1	NNP
cord-006229-7yoilsho	3554	6	,	,	,
cord-006229-7yoilsho	3554	7	ATF2	ATF2	NNP
cord-006229-7yoilsho	3554	8	,	,	,
cord-006229-7yoilsho	3554	9	E2F-1	E2F-1	NNP
cord-006229-7yoilsho	3554	10	,	,	,
cord-006229-7yoilsho	3554	11	CBF	CBF	NNP
cord-006229-7yoilsho	3554	12	,	,	,
cord-006229-7yoilsho	3555	1	Stat6	Stat6	NNS
cord-006229-7yoilsho	3555	2	were	be	VBD
cord-006229-7yoilsho	3555	3	identified	identify	VBN
cord-006229-7yoilsho	3555	4	as	as	IN
cord-006229-7yoilsho	3555	5	significantly	significantly	RB
cord-006229-7yoilsho	3555	6	regulated	regulate	VBN
cord-006229-7yoilsho	3555	7	in	in	IN
cord-006229-7yoilsho	3555	8	their	-PRON-	PRP$
cord-006229-7yoilsho	3555	9	activity	activity	NN
cord-006229-7yoilsho	3555	10	.	.	.
cord-006229-7yoilsho	3556	1	For	for	IN
cord-006229-7yoilsho	3556	2	validation	validation	NN
cord-006229-7yoilsho	3556	3	of	of	IN
cord-006229-7yoilsho	3556	4	identified	identify	VBN
cord-006229-7yoilsho	3556	5	transcription	transcription	NN
cord-006229-7yoilsho	3556	6	factors	factor	NNS
cord-006229-7yoilsho	3556	7	,	,	,
cord-006229-7yoilsho	3556	8	studies	study	NNS
cord-006229-7yoilsho	3556	9	on	on	IN
cord-006229-7yoilsho	3556	10	the	the	DT
cord-006229-7yoilsho	3556	11	protein	protein	NN
cord-006229-7yoilsho	3556	12	level	level	NN
cord-006229-7yoilsho	3556	13	of	of	IN
cord-006229-7yoilsho	3556	14	certain	certain	JJ
cord-006229-7yoilsho	3556	15	target	target	NN
cord-006229-7yoilsho	3556	16	genes	gene	NNS
cord-006229-7yoilsho	3556	17	were	be	VBD
cord-006229-7yoilsho	3556	18	performed	perform	VBN
cord-006229-7yoilsho	3556	19	.	.	.
cord-006229-7yoilsho	3557	1	Western	western	JJ
cord-006229-7yoilsho	3557	2	blot	blot	NN
cord-006229-7yoilsho	3557	3	analyses	analysis	NNS
cord-006229-7yoilsho	3557	4	exhibited	exhibit	VBD
cord-006229-7yoilsho	3557	5	an	an	DT
cord-006229-7yoilsho	3557	6	enhanced	enhance	VBN
cord-006229-7yoilsho	3557	7	abundance	abundance	NN
cord-006229-7yoilsho	3557	8	of	of	IN
cord-006229-7yoilsho	3557	9	Sp1	sp1	NN
cord-006229-7yoilsho	3557	10	target	target	NN
cord-006229-7yoilsho	3557	11	genes	gene	NNS
cord-006229-7yoilsho	3557	12	p21	p21	NN
cord-006229-7yoilsho	3557	13	and	and	CC
cord-006229-7yoilsho	3557	14	COX-2	COX-2	NNP
cord-006229-7yoilsho	3557	15	as	as	RB
cord-006229-7yoilsho	3557	16	well	well	RB
cord-006229-7yoilsho	3557	17	as	as	IN
cord-006229-7yoilsho	3557	18	a	a	DT
cord-006229-7yoilsho	3557	19	raise	raise	NN
cord-006229-7yoilsho	3557	20	in	in	IN
cord-006229-7yoilsho	3557	21	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	3557	22	of	of	IN
cord-006229-7yoilsho	3557	23	c	c	NN
cord-006229-7yoilsho	3557	24	-	-	:
cord-006229-7yoilsho	3557	25	Jun	Jun	NNP
cord-006229-7yoilsho	3557	26	.	.	.
cord-006229-7yoilsho	3558	1	In	in	IN
cord-006229-7yoilsho	3558	2	contrast	contrast	NN
cord-006229-7yoilsho	3558	3	,	,	,
cord-006229-7yoilsho	3558	4	the	the	DT
cord-006229-7yoilsho	3558	5	level	level	NN
cord-006229-7yoilsho	3558	6	of	of	IN
cord-006229-7yoilsho	3558	7	apoptosisinducing	apoptosisinduce	VBG
cord-006229-7yoilsho	3558	8	GADD153	GADD153	NNP
cord-006229-7yoilsho	3558	9	,	,	,
cord-006229-7yoilsho	3558	10	a	a	DT
cord-006229-7yoilsho	3558	11	target	target	NN
cord-006229-7yoilsho	3558	12	gene	gene	NN
cord-006229-7yoilsho	3558	13	of	of	IN
cord-006229-7yoilsho	3558	14	ATF2	ATF2	NNP
cord-006229-7yoilsho	3558	15	,	,	,
cord-006229-7yoilsho	3558	16	was	be	VBD
cord-006229-7yoilsho	3558	17	decreased	decrease	VBN
cord-006229-7yoilsho	3558	18	.	.	.
cord-006229-7yoilsho	3559	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	3559	2	results	result	NNS
cord-006229-7yoilsho	3559	3	suggest	suggest	VBP
cord-006229-7yoilsho	3559	4	that	that	IN
cord-006229-7yoilsho	3559	5	C3	C3	NNP
cord-006229-7yoilsho	3559	6	is	be	VBZ
cord-006229-7yoilsho	3559	7	able	able	JJ
cord-006229-7yoilsho	3559	8	to	to	TO
cord-006229-7yoilsho	3559	9	modulate	modulate	VB
cord-006229-7yoilsho	3559	10	the	the	DT
cord-006229-7yoilsho	3559	11	activity	activity	NN
cord-006229-7yoilsho	3559	12	of	of	IN
cord-006229-7yoilsho	3559	13	transcription	transcription	NN
cord-006229-7yoilsho	3559	14	factors	factor	NNS
cord-006229-7yoilsho	3559	15	whose	whose	WP$
cord-006229-7yoilsho	3559	16	target	target	NN
cord-006229-7yoilsho	3559	17	genes	gene	NNS
cord-006229-7yoilsho	3559	18	are	be	VBP
cord-006229-7yoilsho	3559	19	involved	involve	VBN
cord-006229-7yoilsho	3559	20	in	in	IN
cord-006229-7yoilsho	3559	21	the	the	DT
cord-006229-7yoilsho	3559	22	regulation	regulation	NN
cord-006229-7yoilsho	3559	23	of	of	IN
cord-006229-7yoilsho	3559	24	cell	cell	NN
cord-006229-7yoilsho	3559	25	proliferation	proliferation	NN
cord-006229-7yoilsho	3559	26	and	and	CC
cord-006229-7yoilsho	3559	27	apoptosis	apoptosis	NN
cord-006229-7yoilsho	3559	28	.	.	.
cord-006229-7yoilsho	3560	1	Via	via	IN
cord-006229-7yoilsho	3560	2	covalent	covalent	JJ
cord-006229-7yoilsho	3560	3	binding	binding	NN
cord-006229-7yoilsho	3560	4	of	of	IN
cord-006229-7yoilsho	3560	5	chemical	chemical	JJ
cord-006229-7yoilsho	3560	6	compounds	compound	NNS
cord-006229-7yoilsho	3560	7	to	to	IN
cord-006229-7yoilsho	3560	8	DNA	dna	NN
cord-006229-7yoilsho	3560	9	,	,	,
cord-006229-7yoilsho	3560	10	adducts	adduct	NNS
cord-006229-7yoilsho	3560	11	can	can	MD
cord-006229-7yoilsho	3560	12	be	be	VB
cord-006229-7yoilsho	3560	13	formed	form	VBN
cord-006229-7yoilsho	3560	14	.	.	.
cord-006229-7yoilsho	3561	1	As	as	IN
cord-006229-7yoilsho	3561	2	a	a	DT
cord-006229-7yoilsho	3561	3	consequence	consequence	NN
cord-006229-7yoilsho	3561	4	,	,	,
cord-006229-7yoilsho	3561	5	mutations	mutation	NNS
cord-006229-7yoilsho	3561	6	may	may	MD
cord-006229-7yoilsho	3561	7	occur	occur	VB
cord-006229-7yoilsho	3561	8	,	,	,
cord-006229-7yoilsho	3561	9	which	which	WDT
cord-006229-7yoilsho	3561	10	represent	represent	VBP
cord-006229-7yoilsho	3561	11	stages	stage	NNS
cord-006229-7yoilsho	3561	12	of	of	IN
cord-006229-7yoilsho	3561	13	chemical	chemical	NN
cord-006229-7yoilsho	3561	14	mutagenesis	mutagenesis	NN
cord-006229-7yoilsho	3561	15	and	and	CC
cord-006229-7yoilsho	3561	16	carcinogenesis	carcinogenesis	NN
cord-006229-7yoilsho	3561	17	.	.	.
cord-006229-7yoilsho	3562	1	The	the	DT
cord-006229-7yoilsho	3562	2	isolation	isolation	NN
cord-006229-7yoilsho	3562	3	of	of	IN
cord-006229-7yoilsho	3562	4	leucocytes	leucocytes	NNP
cord-006229-7yoilsho	3562	5	represents	represent	VBZ
cord-006229-7yoilsho	3562	6	an	an	DT
cord-006229-7yoilsho	3562	7	essential	essential	JJ
cord-006229-7yoilsho	3562	8	field	field	NN
cord-006229-7yoilsho	3562	9	of	of	IN
cord-006229-7yoilsho	3562	10	work	work	NN
cord-006229-7yoilsho	3562	11	within	within	IN
cord-006229-7yoilsho	3562	12	DNA	dna	NN
cord-006229-7yoilsho	3562	13	-	-	HYPH
cord-006229-7yoilsho	3562	14	adductomics	adductomic	NNS
cord-006229-7yoilsho	3562	15	of	of	IN
cord-006229-7yoilsho	3562	16	blood	blood	NN
cord-006229-7yoilsho	3562	17	cells	cell	NNS
cord-006229-7yoilsho	3562	18	,	,	,
cord-006229-7yoilsho	3562	19	in	in	IN
cord-006229-7yoilsho	3562	20	which	which	WDT
cord-006229-7yoilsho	3562	21	adducts	adduct	NNS
cord-006229-7yoilsho	3562	22	serve	serve	VBP
cord-006229-7yoilsho	3562	23	as	as	IN
cord-006229-7yoilsho	3562	24	markers	marker	NNS
cord-006229-7yoilsho	3562	25	of	of	IN
cord-006229-7yoilsho	3562	26	exposure	exposure	NN
cord-006229-7yoilsho	3562	27	for	for	IN
cord-006229-7yoilsho	3562	28	biological	biological	JJ
cord-006229-7yoilsho	3562	29	monitoring	monitoring	NN
cord-006229-7yoilsho	3562	30	.	.	.
cord-006229-7yoilsho	3563	1	Peripheral	peripheral	JJ
cord-006229-7yoilsho	3563	2	mononuclear	mononuclear	JJ
cord-006229-7yoilsho	3563	3	blood	blood	NN
cord-006229-7yoilsho	3563	4	cells	cell	NNS
cord-006229-7yoilsho	3563	5	(	(	-LRB-
cord-006229-7yoilsho	3563	6	PBMC	PBMC	NNP
cord-006229-7yoilsho	3563	7	)	)	-RRB-
cord-006229-7yoilsho	3563	8	comprising	comprise	VBG
cord-006229-7yoilsho	3563	9	monocytes	monocyte	NNS
cord-006229-7yoilsho	3563	10	and	and	CC
cord-006229-7yoilsho	3563	11	lymphocytes	lymphocyte	NNS
cord-006229-7yoilsho	3563	12	can	can	MD
cord-006229-7yoilsho	3563	13	be	be	VB
cord-006229-7yoilsho	3563	14	separated	separate	VBN
cord-006229-7yoilsho	3563	15	from	from	IN
cord-006229-7yoilsho	3563	16	other	other	JJ
cord-006229-7yoilsho	3563	17	blood	blood	NN
cord-006229-7yoilsho	3563	18	cells	cell	NNS
cord-006229-7yoilsho	3563	19	like	like	IN
cord-006229-7yoilsho	3563	20	granulocytes	granulocyte	NNS
cord-006229-7yoilsho	3563	21	,	,	,
cord-006229-7yoilsho	3563	22	erythrocytes	erythrocyte	NNS
cord-006229-7yoilsho	3563	23	(	(	-LRB-
cord-006229-7yoilsho	3563	24	and	and	CC
cord-006229-7yoilsho	3563	25	dead	dead	JJ
cord-006229-7yoilsho	3563	26	cells	cell	NNS
cord-006229-7yoilsho	3563	27	)	)	-RRB-
cord-006229-7yoilsho	3563	28	by	by	IN
cord-006229-7yoilsho	3563	29	isopycnic	isopycnic	JJ
cord-006229-7yoilsho	3563	30	density	density	NN
cord-006229-7yoilsho	3563	31	gradient	gradient	NN
cord-006229-7yoilsho	3563	32	centrifugation	centrifugation	NN
cord-006229-7yoilsho	3563	33	of	of	IN
cord-006229-7yoilsho	3563	34	Buffy	Buffy	NNP
cord-006229-7yoilsho	3563	35	Coats	Coats	NNP
cord-006229-7yoilsho	3563	36	(	(	-LRB-
cord-006229-7yoilsho	3563	37	BC´s	BC´s	NNP
cord-006229-7yoilsho	3563	38	)	)	-RRB-
cord-006229-7yoilsho	3563	39	.	.	.
cord-006229-7yoilsho	3564	1	BC´s	BC´s	NNP
cord-006229-7yoilsho	3564	2	are	be	VBP
cord-006229-7yoilsho	3564	3	blood	blood	NN
cord-006229-7yoilsho	3564	4	concentrates	concentrate	VBZ
cord-006229-7yoilsho	3564	5	rich	rich	JJ
cord-006229-7yoilsho	3564	6	in	in	IN
cord-006229-7yoilsho	3564	7	leucocytes	leucocyte	NNS
cord-006229-7yoilsho	3564	8	and	and	CC
cord-006229-7yoilsho	3564	9	thrombocytes	thrombocyte	NNS
cord-006229-7yoilsho	3564	10	,	,	,
cord-006229-7yoilsho	3564	11	prepared	prepare	VBN
cord-006229-7yoilsho	3564	12	from	from	IN
cord-006229-7yoilsho	3564	13	whole	whole	JJ
cord-006229-7yoilsho	3564	14	blood	blood	NN
cord-006229-7yoilsho	3564	15	samples	sample	VBZ
cord-006229-7yoilsho	3564	16	thorough	thorough	JJ
cord-006229-7yoilsho	3564	17	removal	removal	NN
cord-006229-7yoilsho	3564	18	of	of	IN
cord-006229-7yoilsho	3564	19	plasma	plasma	NN
cord-006229-7yoilsho	3564	20	and	and	CC
cord-006229-7yoilsho	3564	21	erythrocytes	erythrocyte	NNS
cord-006229-7yoilsho	3564	22	.	.	.
cord-006229-7yoilsho	3565	1	For	for	IN
cord-006229-7yoilsho	3565	2	the	the	DT
cord-006229-7yoilsho	3565	3	experiments	experiment	NNS
cord-006229-7yoilsho	3565	4	only	only	RB
cord-006229-7yoilsho	3565	5	BC´s	BC´s	NNP
cord-006229-7yoilsho	3565	6	from	from	IN
cord-006229-7yoilsho	3565	7	healthy	healthy	JJ
cord-006229-7yoilsho	3565	8	donors	donor	NNS
cord-006229-7yoilsho	3565	9	were	be	VBD
cord-006229-7yoilsho	3565	10	used	use	VBN
cord-006229-7yoilsho	3565	11	.	.	.
cord-006229-7yoilsho	3566	1	While	while	IN
cord-006229-7yoilsho	3566	2	erythrocytes	erythrocyte	NNS
cord-006229-7yoilsho	3566	3	contain	contain	VBP
cord-006229-7yoilsho	3566	4	no	no	DT
cord-006229-7yoilsho	3566	5	DNA	dna	NN
cord-006229-7yoilsho	3566	6	,	,	,
cord-006229-7yoilsho	3566	7	lymphocytes	lymphocyte	NNS
cord-006229-7yoilsho	3566	8	,	,	,
cord-006229-7yoilsho	3566	9	which	which	WDT
cord-006229-7yoilsho	3566	10	constitute	constitute	VBP
cord-006229-7yoilsho	3566	11	a	a	DT
cord-006229-7yoilsho	3566	12	subcategory	subcategory	NN
cord-006229-7yoilsho	3566	13	of	of	IN
cord-006229-7yoilsho	3566	14	leucocytes	leucocyte	NNS
cord-006229-7yoilsho	3566	15	,	,	,
cord-006229-7yoilsho	3566	16	carry	carry	VB
cord-006229-7yoilsho	3566	17	genetic	genetic	JJ
cord-006229-7yoilsho	3566	18	information	information	NN
cord-006229-7yoilsho	3566	19	.	.	.
cord-006229-7yoilsho	3567	1	A	a	DT
cord-006229-7yoilsho	3567	2	variety	variety	NN
cord-006229-7yoilsho	3567	3	of	of	IN
cord-006229-7yoilsho	3567	4	commercially	commercially	RB
cord-006229-7yoilsho	3567	5	available	available	JJ
cord-006229-7yoilsho	3567	6	fluids	fluid	NNS
cord-006229-7yoilsho	3567	7	with	with	IN
cord-006229-7yoilsho	3567	8	a	a	DT
cord-006229-7yoilsho	3567	9	density	density	NN
cord-006229-7yoilsho	3567	10	of	of	IN
cord-006229-7yoilsho	3567	11	1.077g	1.077g	CD
cord-006229-7yoilsho	3567	12	/	/	SYM
cord-006229-7yoilsho	3567	13	cm	cm	NN
cord-006229-7yoilsho	3567	14	3	3	CD
cord-006229-7yoilsho	3567	15	,	,	,
cord-006229-7yoilsho	3567	16	based	base	VBN
cord-006229-7yoilsho	3567	17	on	on	IN
cord-006229-7yoilsho	3567	18	different	different	JJ
cord-006229-7yoilsho	3567	19	polymers	polymer	NNS
cord-006229-7yoilsho	3567	20	,	,	,
cord-006229-7yoilsho	3567	21	exists	exist	VBZ
cord-006229-7yoilsho	3567	22	.	.	.
cord-006229-7yoilsho	3568	1	These	these	DT
cord-006229-7yoilsho	3568	2	materials	material	NNS
cord-006229-7yoilsho	3568	3	form	form	VBP
cord-006229-7yoilsho	3568	4	the	the	DT
cord-006229-7yoilsho	3568	5	gradient	gradient	NN
cord-006229-7yoilsho	3568	6	required	require	VBN
cord-006229-7yoilsho	3568	7	for	for	IN
cord-006229-7yoilsho	3568	8	the	the	DT
cord-006229-7yoilsho	3568	9	centrifugation	centrifugation	NN
cord-006229-7yoilsho	3568	10	.	.	.
cord-006229-7yoilsho	3569	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	3569	2	,	,	,
cord-006229-7yoilsho	3569	3	there	there	EX
cord-006229-7yoilsho	3569	4	are	be	VBP
cord-006229-7yoilsho	3569	5	several	several	JJ
cord-006229-7yoilsho	3569	6	methods	method	NNS
cord-006229-7yoilsho	3569	7	available	available	JJ
cord-006229-7yoilsho	3569	8	,	,	,
cord-006229-7yoilsho	3569	9	which	which	WDT
cord-006229-7yoilsho	3569	10	differ	differ	VBP
cord-006229-7yoilsho	3569	11	in	in	IN
cord-006229-7yoilsho	3569	12	the	the	DT
cord-006229-7yoilsho	3569	13	ratio	ratio	NN
cord-006229-7yoilsho	3569	14	blood	blood	NN
cord-006229-7yoilsho	3569	15	vs.	vs.	IN
cord-006229-7yoilsho	3569	16	fluid	fluid	NN
cord-006229-7yoilsho	3569	17	,	,	,
cord-006229-7yoilsho	3569	18	duration	duration	NN
cord-006229-7yoilsho	3569	19	of	of	IN
cord-006229-7yoilsho	3569	20	the	the	DT
cord-006229-7yoilsho	3569	21	different	different	JJ
cord-006229-7yoilsho	3569	22	work	work	NN
cord-006229-7yoilsho	3569	23	up	up	RP
cord-006229-7yoilsho	3569	24	steps	step	NNS
cord-006229-7yoilsho	3569	25	,	,	,
cord-006229-7yoilsho	3569	26	centrifugation	centrifugation	NN
cord-006229-7yoilsho	3569	27	parameters	parameter	NNS
cord-006229-7yoilsho	3569	28	and	and	CC
cord-006229-7yoilsho	3569	29	others	other	NNS
cord-006229-7yoilsho	3569	30	.	.	.
cord-006229-7yoilsho	3570	1	The	the	DT
cord-006229-7yoilsho	3570	2	aim	aim	NN
cord-006229-7yoilsho	3570	3	of	of	IN
cord-006229-7yoilsho	3570	4	this	this	DT
cord-006229-7yoilsho	3570	5	work	work	NN
cord-006229-7yoilsho	3570	6	was	be	VBD
cord-006229-7yoilsho	3570	7	to	to	TO
cord-006229-7yoilsho	3570	8	compare	compare	VB
cord-006229-7yoilsho	3570	9	the	the	DT
cord-006229-7yoilsho	3570	10	effectivity	effectivity	NN
cord-006229-7yoilsho	3570	11	of	of	IN
cord-006229-7yoilsho	3570	12	the	the	DT
cord-006229-7yoilsho	3570	13	different	different	JJ
cord-006229-7yoilsho	3570	14	fluids	fluid	NNS
cord-006229-7yoilsho	3570	15	and	and	CC
cord-006229-7yoilsho	3570	16	optimize	optimize	VB
cord-006229-7yoilsho	3570	17	the	the	DT
cord-006229-7yoilsho	3570	18	workflow	workflow	NN
cord-006229-7yoilsho	3570	19	.	.	.
cord-006229-7yoilsho	3571	1	For	for	IN
cord-006229-7yoilsho	3571	2	isolation	isolation	NN
cord-006229-7yoilsho	3571	3	of	of	IN
cord-006229-7yoilsho	3571	4	PBMC	PBMC	NNP
cord-006229-7yoilsho	3571	5	the	the	DT
cord-006229-7yoilsho	3571	6	fluid	fluid	NN
cord-006229-7yoilsho	3571	7	was	be	VBD
cord-006229-7yoilsho	3571	8	put	put	VBN
cord-006229-7yoilsho	3571	9	in	in	IN
cord-006229-7yoilsho	3571	10	a	a	DT
cord-006229-7yoilsho	3571	11	tube	tube	NN
cord-006229-7yoilsho	3571	12	and	and	CC
cord-006229-7yoilsho	3571	13	then	then	RB
cord-006229-7yoilsho	3571	14	covered	cover	VBN
cord-006229-7yoilsho	3571	15	by	by	IN
cord-006229-7yoilsho	3571	16	a	a	DT
cord-006229-7yoilsho	3571	17	thin	thin	JJ
cord-006229-7yoilsho	3571	18	layer	layer	NN
cord-006229-7yoilsho	3571	19	of	of	IN
cord-006229-7yoilsho	3571	20	blood	blood	NN
cord-006229-7yoilsho	3571	21	.	.	.
cord-006229-7yoilsho	3572	1	After	after	IN
cord-006229-7yoilsho	3572	2	centrifugation	centrifugation	NN
cord-006229-7yoilsho	3572	3	,	,	,
cord-006229-7yoilsho	3572	4	five	five	CD
cord-006229-7yoilsho	3572	5	layers	layer	NNS
cord-006229-7yoilsho	3572	6	were	be	VBD
cord-006229-7yoilsho	3572	7	obtained	obtain	VBN
cord-006229-7yoilsho	3572	8	(	(	-LRB-
cord-006229-7yoilsho	3572	9	Figure	figure	NN
cord-006229-7yoilsho	3572	10	1	1	CD
cord-006229-7yoilsho	3572	11	)	)	-RRB-
cord-006229-7yoilsho	3572	12	.	.	.
cord-006229-7yoilsho	3573	1	The	the	DT
cord-006229-7yoilsho	3573	2	interphase	interphase	NN
cord-006229-7yoilsho	3573	3	was	be	VBD
cord-006229-7yoilsho	3573	4	removed	remove	VBN
cord-006229-7yoilsho	3573	5	carefully	carefully	RB
cord-006229-7yoilsho	3573	6	,	,	,
cord-006229-7yoilsho	3573	7	washed	wash	VBN
cord-006229-7yoilsho	3573	8	and	and	CC
cord-006229-7yoilsho	3573	9	the	the	DT
cord-006229-7yoilsho	3573	10	cells	cell	NNS
cord-006229-7yoilsho	3573	11	were	be	VBD
cord-006229-7yoilsho	3573	12	counted	count	VBN
cord-006229-7yoilsho	3573	13	.	.	.
cord-006229-7yoilsho	3574	1	The	the	DT
cord-006229-7yoilsho	3574	2	yield	yield	NN
cord-006229-7yoilsho	3574	3	is	be	VBZ
cord-006229-7yoilsho	3574	4	expressed	express	VBN
cord-006229-7yoilsho	3574	5	as	as	IN
cord-006229-7yoilsho	3574	6	percentage	percentage	NN
cord-006229-7yoilsho	3574	7	of	of	IN
cord-006229-7yoilsho	3574	8	isolated	isolate	VBN
cord-006229-7yoilsho	3574	9	vs.	vs.	IN
cord-006229-7yoilsho	3574	10	total	total	JJ
cord-006229-7yoilsho	3574	11	leucocytes	leucocyte	NNS
cord-006229-7yoilsho	3574	12	in	in	IN
cord-006229-7yoilsho	3574	13	the	the	DT
cord-006229-7yoilsho	3574	14	BC	BC	NNP
cord-006229-7yoilsho	3574	15	,	,	,
cord-006229-7yoilsho	3574	16	which	which	WDT
cord-006229-7yoilsho	3574	17	was	be	VBD
cord-006229-7yoilsho	3574	18	based	base	VBN
cord-006229-7yoilsho	3574	19	on	on	IN
cord-006229-7yoilsho	3574	20	the	the	DT
cord-006229-7yoilsho	3574	21	leucocyte	leucocyte	NNP
cord-006229-7yoilsho	3574	22	count	count	NN
cord-006229-7yoilsho	3574	23	of	of	IN
cord-006229-7yoilsho	3574	24	the	the	DT
cord-006229-7yoilsho	3574	25	whole	whole	JJ
cord-006229-7yoilsho	3574	26	blood	blood	NN
cord-006229-7yoilsho	3574	27	sample	sample	NN
cord-006229-7yoilsho	3574	28	.	.	.
cord-006229-7yoilsho	3575	1	As	as	IN
cord-006229-7yoilsho	3575	2	separation	separation	NN
cord-006229-7yoilsho	3575	3	fluids	fluid	NNS
cord-006229-7yoilsho	3575	4	,	,	,
cord-006229-7yoilsho	3575	5	Ficoll	Ficoll	NNP
cord-006229-7yoilsho	3575	6	®	®	POS
cord-006229-7yoilsho	3575	7	Paque	Paque	NNP
cord-006229-7yoilsho	3575	8	Plus	Plus	NNP
cord-006229-7yoilsho	3575	9	(	(	-LRB-
cord-006229-7yoilsho	3575	10	GE	GE	NNP
cord-006229-7yoilsho	3575	11	Healthcare	Healthcare	NNP
cord-006229-7yoilsho	3575	12	)	)	-RRB-
cord-006229-7yoilsho	3575	13	,	,	,
cord-006229-7yoilsho	3575	14	Histopaque	Histopaque	NNP
cord-006229-7yoilsho	3575	15	®	®	.
cord-006229-7yoilsho	3575	16	(	(	-LRB-
cord-006229-7yoilsho	3575	17	Sigma	Sigma	NNP
cord-006229-7yoilsho	3575	18	Aldrich	Aldrich	NNP
cord-006229-7yoilsho	3575	19	)	)	-RRB-
cord-006229-7yoilsho	3575	20	and	and	CC
cord-006229-7yoilsho	3575	21	LSM	LSM	NNP
cord-006229-7yoilsho	3575	22	®	®	.
cord-006229-7yoilsho	3575	23	(	(	-LRB-
cord-006229-7yoilsho	3575	24	GE	GE	NNP
cord-006229-7yoilsho	3575	25	Healthcare	Healthcare	NNP
cord-006229-7yoilsho	3575	26	)	)	-RRB-
cord-006229-7yoilsho	3575	27	were	be	VBD
cord-006229-7yoilsho	3575	28	tested	test	VBN
cord-006229-7yoilsho	3575	29	.	.	.
cord-006229-7yoilsho	3576	1	No	no	DT
cord-006229-7yoilsho	3576	2	significant	significant	JJ
cord-006229-7yoilsho	3576	3	differences	difference	NNS
cord-006229-7yoilsho	3576	4	between	between	IN
cord-006229-7yoilsho	3576	5	the	the	DT
cord-006229-7yoilsho	3576	6	different	different	JJ
cord-006229-7yoilsho	3576	7	fluids	fluid	NNS
cord-006229-7yoilsho	3576	8	were	be	VBD
cord-006229-7yoilsho	3576	9	observed	observe	VBN
cord-006229-7yoilsho	3576	10	.	.	.
cord-006229-7yoilsho	3577	1	Although	although	IN
cord-006229-7yoilsho	3577	2	dilution	dilution	NN
cord-006229-7yoilsho	3577	3	is	be	VBZ
cord-006229-7yoilsho	3577	4	often	often	RB
cord-006229-7yoilsho	3577	5	recommended	recommend	VBN
cord-006229-7yoilsho	3577	6	in	in	IN
cord-006229-7yoilsho	3577	7	literature	literature	NN
cord-006229-7yoilsho	3577	8	,	,	,
cord-006229-7yoilsho	3577	9	it	-PRON-	PRP
cord-006229-7yoilsho	3577	10	was	be	VBD
cord-006229-7yoilsho	3577	11	found	find	VBN
cord-006229-7yoilsho	3577	12	that	that	IN
cord-006229-7yoilsho	3577	13	dilution	dilution	NN
cord-006229-7yoilsho	3577	14	had	have	VBD
cord-006229-7yoilsho	3577	15	no	no	DT
cord-006229-7yoilsho	3577	16	effect	effect	NN
cord-006229-7yoilsho	3577	17	on	on	IN
cord-006229-7yoilsho	3577	18	the	the	DT
cord-006229-7yoilsho	3577	19	yield	yield	NN
cord-006229-7yoilsho	3577	20	.	.	.
cord-006229-7yoilsho	3578	1	Similarly	similarly	RB
cord-006229-7yoilsho	3578	2	,	,	,
cord-006229-7yoilsho	3578	3	using	use	VBG
cord-006229-7yoilsho	3578	4	different	different	JJ
cord-006229-7yoilsho	3578	5	fluids	fluid	NNS
cord-006229-7yoilsho	3578	6	(	(	-LRB-
cord-006229-7yoilsho	3578	7	RPMI	RPMI	NNP
cord-006229-7yoilsho	3578	8	or	or	CC
cord-006229-7yoilsho	3578	9	PBS	PBS	NNP
cord-006229-7yoilsho	3578	10	)	)	-RRB-
cord-006229-7yoilsho	3578	11	for	for	IN
cord-006229-7yoilsho	3578	12	the	the	DT
cord-006229-7yoilsho	3578	13	washing	washing	NN
cord-006229-7yoilsho	3578	14	steps	step	NNS
cord-006229-7yoilsho	3578	15	did	do	VBD
cord-006229-7yoilsho	3578	16	not	not	RB
cord-006229-7yoilsho	3578	17	reveal	reveal	VB
cord-006229-7yoilsho	3578	18	any	any	DT
cord-006229-7yoilsho	3578	19	differences	difference	NNS
cord-006229-7yoilsho	3578	20	.	.	.
cord-006229-7yoilsho	3579	1	Increasing	increase	VBG
cord-006229-7yoilsho	3579	2	centrifugation	centrifugation	NN
cord-006229-7yoilsho	3579	3	speed	speed	NN
cord-006229-7yoilsho	3579	4	from	from	IN
cord-006229-7yoilsho	3579	5	400	400	CD
cord-006229-7yoilsho	3579	6	to	to	TO
cord-006229-7yoilsho	3579	7	500	500	CD
cord-006229-7yoilsho	3579	8	xg	xg	NNS
cord-006229-7yoilsho	3579	9	resulted	result	VBD
cord-006229-7yoilsho	3579	10	in	in	IN
cord-006229-7yoilsho	3579	11	higher	high	JJR
cord-006229-7yoilsho	3579	12	yields	yield	NNS
cord-006229-7yoilsho	3579	13	.	.	.
cord-006229-7yoilsho	3580	1	In	in	IN
cord-006229-7yoilsho	3580	2	general	general	JJ
cord-006229-7yoilsho	3580	3	,	,	,
cord-006229-7yoilsho	3580	4	large	large	JJ
cord-006229-7yoilsho	3580	5	variations	variation	NNS
cord-006229-7yoilsho	3580	6	in	in	IN
cord-006229-7yoilsho	3580	7	yield	yield	NN
cord-006229-7yoilsho	3580	8	(	(	-LRB-
cord-006229-7yoilsho	3580	9	46.8	46.8	CD
cord-006229-7yoilsho	3580	10	%	%	NN
cord-006229-7yoilsho	3580	11	±	±	NNP
cord-006229-7yoilsho	3580	12	17.1	17.1	CD
cord-006229-7yoilsho	3580	13	%	%	NN
cord-006229-7yoilsho	3580	14	)	)	-RRB-
cord-006229-7yoilsho	3580	15	among	among	IN
cord-006229-7yoilsho	3580	16	the	the	DT
cord-006229-7yoilsho	3580	17	various	various	JJ
cord-006229-7yoilsho	3580	18	BC´s	BC´s	NNP
cord-006229-7yoilsho	3580	19	arose	arise	VBD
cord-006229-7yoilsho	3580	20	.	.	.
cord-006229-7yoilsho	3581	1	This	this	DT
cord-006229-7yoilsho	3581	2	result	result	NN
cord-006229-7yoilsho	3581	3	is	be	VBZ
cord-006229-7yoilsho	3581	4	due	due	JJ
cord-006229-7yoilsho	3581	5	to	to	IN
cord-006229-7yoilsho	3581	6	the	the	DT
cord-006229-7yoilsho	3581	7	different	different	JJ
cord-006229-7yoilsho	3581	8	parameters	parameter	NNS
cord-006229-7yoilsho	3581	9	such	such	JJ
cord-006229-7yoilsho	3581	10	as	as	IN
cord-006229-7yoilsho	3581	11	age	age	NN
cord-006229-7yoilsho	3581	12	,	,	,
cord-006229-7yoilsho	3581	13	storage	storage	NN
cord-006229-7yoilsho	3581	14	,	,	,
cord-006229-7yoilsho	3581	15	leucocyte	leucocyte	NN
cord-006229-7yoilsho	3581	16	and	and	CC
cord-006229-7yoilsho	3581	17	erythrocyte	erythrocyte	NN
cord-006229-7yoilsho	3581	18	counts	count	NNS
cord-006229-7yoilsho	3581	19	of	of	IN
cord-006229-7yoilsho	3581	20	the	the	DT
cord-006229-7yoilsho	3581	21	different	different	JJ
cord-006229-7yoilsho	3581	22	BC´s	BC´s	NNP
cord-006229-7yoilsho	3581	23	used	use	VBN
cord-006229-7yoilsho	3581	24	.	.	.
cord-006229-7yoilsho	3582	1	Therefore	therefore	RB
cord-006229-7yoilsho	3582	2	,	,	,
cord-006229-7yoilsho	3582	3	the	the	DT
cord-006229-7yoilsho	3582	4	test	test	NN
cord-006229-7yoilsho	3582	5	conditions	condition	NNS
cord-006229-7yoilsho	3582	6	were	be	VBD
cord-006229-7yoilsho	3582	7	optimized	optimize	VBN
cord-006229-7yoilsho	3582	8	using	use	VBG
cord-006229-7yoilsho	3582	9	the	the	DT
cord-006229-7yoilsho	3582	10	same	same	JJ
cord-006229-7yoilsho	3582	11	batch	batch	NN
cord-006229-7yoilsho	3582	12	of	of	IN
cord-006229-7yoilsho	3582	13	BC	BC	NNP
cord-006229-7yoilsho	3582	14	.	.	.
cord-006229-7yoilsho	3583	1	The	the	DT
cord-006229-7yoilsho	3583	2	results	result	NNS
cord-006229-7yoilsho	3583	3	show	show	VBP
cord-006229-7yoilsho	3583	4	that	that	IN
cord-006229-7yoilsho	3583	5	the	the	DT
cord-006229-7yoilsho	3583	6	low	low	JJ
cord-006229-7yoilsho	3583	7	priced	price	VBN
cord-006229-7yoilsho	3583	8	separation	separation	NN
cord-006229-7yoilsho	3583	9	fluids	fluid	NNS
cord-006229-7yoilsho	3583	10	are	be	VBP
cord-006229-7yoilsho	3583	11	comparable	comparable	JJ
cord-006229-7yoilsho	3583	12	in	in	IN
cord-006229-7yoilsho	3583	13	performance	performance	NN
cord-006229-7yoilsho	3583	14	tothe	tothe	DT
cord-006229-7yoilsho	3583	15	more	more	RBR
cord-006229-7yoilsho	3583	16	expensive	expensive	JJ
cord-006229-7yoilsho	3583	17	ones	one	NNS
cord-006229-7yoilsho	3583	18	.	.	.
cord-006229-7yoilsho	3584	1	By	by	IN
cord-006229-7yoilsho	3584	2	the	the	DT
cord-006229-7yoilsho	3584	3	direct	direct	JJ
cord-006229-7yoilsho	3584	4	lamination	lamination	NN
cord-006229-7yoilsho	3584	5	with	with	IN
cord-006229-7yoilsho	3584	6	BC	BC	NNP
cord-006229-7yoilsho	3584	7	(	(	-LRB-
cord-006229-7yoilsho	3584	8	without	without	IN
cord-006229-7yoilsho	3584	9	dilution	dilution	NN
cord-006229-7yoilsho	3584	10	)	)	-RRB-
cord-006229-7yoilsho	3585	1	the	the	DT
cord-006229-7yoilsho	3585	2	wastage	wastage	NN
cord-006229-7yoilsho	3585	3	could	could	MD
cord-006229-7yoilsho	3585	4	be	be	VB
cord-006229-7yoilsho	3585	5	minimized	minimize	VBN
cord-006229-7yoilsho	3585	6	,	,	,
cord-006229-7yoilsho	3585	7	the	the	DT
cord-006229-7yoilsho	3585	8	yield	yield	NN
cord-006229-7yoilsho	3585	9	increased	increase	VBD
cord-006229-7yoilsho	3585	10	and	and	CC
cord-006229-7yoilsho	3585	11	thus	thus	RB
cord-006229-7yoilsho	3585	12	the	the	DT
cord-006229-7yoilsho	3585	13	isolation	isolation	NN
cord-006229-7yoilsho	3585	14	made	make	VBD
cord-006229-7yoilsho	3585	15	more	more	RBR
cord-006229-7yoilsho	3585	16	efficient	efficient	JJ
cord-006229-7yoilsho	3585	17	.	.	.
cord-006229-7yoilsho	3586	1	The	the	DT
cord-006229-7yoilsho	3586	2	Franz	Franz	NNP
cord-006229-7yoilsho	3586	3	cell	cell	NN
cord-006229-7yoilsho	3586	4	is	be	VBZ
cord-006229-7yoilsho	3586	5	a	a	DT
cord-006229-7yoilsho	3586	6	well	well	RB
cord-006229-7yoilsho	3586	7	-	-	HYPH
cord-006229-7yoilsho	3586	8	established	establish	VBN
cord-006229-7yoilsho	3586	9	model	model	NN
cord-006229-7yoilsho	3586	10	in	in	IN
cord-006229-7yoilsho	3586	11	lots	lot	NNS
cord-006229-7yoilsho	3586	12	of	of	IN
cord-006229-7yoilsho	3586	13	skin	skin	NN
cord-006229-7yoilsho	3586	14	research	research	NN
cord-006229-7yoilsho	3586	15	fields	field	NNS
cord-006229-7yoilsho	3586	16	.	.	.
cord-006229-7yoilsho	3587	1	We	-PRON-	PRP
cord-006229-7yoilsho	3587	2	adapted	adapt	VBD
cord-006229-7yoilsho	3587	3	the	the	DT
cord-006229-7yoilsho	3587	4	diffusion	diffusion	NN
cord-006229-7yoilsho	3587	5	cell	cell	NN
cord-006229-7yoilsho	3587	6	system	system	NN
cord-006229-7yoilsho	3587	7	to	to	IN
cord-006229-7yoilsho	3587	8	additives	additive	NNS
cord-006229-7yoilsho	3587	9	and	and	CC
cord-006229-7yoilsho	3587	10	contaminants	contaminant	NNS
cord-006229-7yoilsho	3587	11	of	of	IN
cord-006229-7yoilsho	3587	12	consumer	consumer	NN
cord-006229-7yoilsho	3587	13	products	product	NNS
cord-006229-7yoilsho	3587	14	which	which	WDT
cord-006229-7yoilsho	3587	15	are	be	VBP
cord-006229-7yoilsho	3587	16	designated	designate	VBN
cord-006229-7yoilsho	3587	17	for	for	IN
cord-006229-7yoilsho	3587	18	skin	skin	NN
cord-006229-7yoilsho	3587	19	contacts	contact	NNS
cord-006229-7yoilsho	3587	20	.	.	.
cord-006229-7yoilsho	3588	1	We	-PRON-	PRP
cord-006229-7yoilsho	3588	2	were	be	VBD
cord-006229-7yoilsho	3588	3	aimed	aim	VBN
cord-006229-7yoilsho	3588	4	to	to	TO
cord-006229-7yoilsho	3588	5	simulate	simulate	VB
cord-006229-7yoilsho	3588	6	real	real	JJ
cord-006229-7yoilsho	3588	7	exposure	exposure	NN
cord-006229-7yoilsho	3588	8	as	as	RB
cord-006229-7yoilsho	3588	9	realistic	realistic	JJ
cord-006229-7yoilsho	3588	10	as	as	IN
cord-006229-7yoilsho	3588	11	possible	possible	JJ
cord-006229-7yoilsho	3588	12	.	.	.
cord-006229-7yoilsho	3589	1	To	to	TO
cord-006229-7yoilsho	3589	2	meet	meet	VB
cord-006229-7yoilsho	3589	3	requirements	requirement	NNS
cord-006229-7yoilsho	3589	4	like	like	IN
cord-006229-7yoilsho	3589	5	longevity	longevity	NN
cord-006229-7yoilsho	3589	6	,	,	,
cord-006229-7yoilsho	3589	7	haptic	haptic	JJ
cord-006229-7yoilsho	3589	8	properties	property	NNS
cord-006229-7yoilsho	3589	9	and	and	CC
cord-006229-7yoilsho	3589	10	factory	factory	NN
cord-006229-7yoilsho	3589	11	costs	cost	NNS
cord-006229-7yoilsho	3589	12	,	,	,
cord-006229-7yoilsho	3589	13	different	different	JJ
cord-006229-7yoilsho	3589	14	polymers	polymer	NNS
cord-006229-7yoilsho	3589	15	are	be	VBP
cord-006229-7yoilsho	3589	16	used	use	VBN
cord-006229-7yoilsho	3589	17	as	as	IN
cord-006229-7yoilsho	3589	18	the	the	DT
cord-006229-7yoilsho	3589	19	raw	raw	JJ
cord-006229-7yoilsho	3589	20	material	material	NN
cord-006229-7yoilsho	3589	21	of	of	IN
cord-006229-7yoilsho	3589	22	choice	choice	NN
cord-006229-7yoilsho	3589	23	and	and	CC
cord-006229-7yoilsho	3589	24	modified	modify	VBN
cord-006229-7yoilsho	3589	25	by	by	IN
cord-006229-7yoilsho	3589	26	a	a	DT
cord-006229-7yoilsho	3589	27	variable	variable	JJ
cord-006229-7yoilsho	3589	28	number	number	NN
cord-006229-7yoilsho	3589	29	of	of	IN
cord-006229-7yoilsho	3589	30	additives	additive	NNS
cord-006229-7yoilsho	3589	31	in	in	IN
cord-006229-7yoilsho	3589	32	the	the	DT
cord-006229-7yoilsho	3589	33	majority	majority	NN
cord-006229-7yoilsho	3589	34	of	of	IN
cord-006229-7yoilsho	3589	35	commodities	commodity	NNS
cord-006229-7yoilsho	3589	36	.	.	.
cord-006229-7yoilsho	3590	1	Besides	besides	IN
cord-006229-7yoilsho	3590	2	additives	additive	NNS
cord-006229-7yoilsho	3590	3	with	with	IN
cord-006229-7yoilsho	3590	4	a	a	DT
cord-006229-7yoilsho	3590	5	defined	define	VBN
cord-006229-7yoilsho	3590	6	function	function	NN
cord-006229-7yoilsho	3590	7	such	such	JJ
cord-006229-7yoilsho	3590	8	as	as	IN
cord-006229-7yoilsho	3590	9	plasticizers	plasticizer	NNS
cord-006229-7yoilsho	3590	10	,	,	,
cord-006229-7yoilsho	3590	11	stabilizers	stabilizer	NNS
cord-006229-7yoilsho	3590	12	,	,	,
cord-006229-7yoilsho	3590	13	colorants	colorant	NNS
cord-006229-7yoilsho	3590	14	and	and	CC
cord-006229-7yoilsho	3590	15	vulcanization	vulcanization	NN
cord-006229-7yoilsho	3590	16	accelerators	accelerator	NNS
cord-006229-7yoilsho	3590	17	,	,	,
cord-006229-7yoilsho	3590	18	contaminants	contaminant	NNS
cord-006229-7yoilsho	3590	19	as	as	RB
cord-006229-7yoilsho	3590	20	well	well	RB
cord-006229-7yoilsho	3590	21	as	as	IN
cord-006229-7yoilsho	3590	22	decomposition	decomposition	NN
cord-006229-7yoilsho	3590	23	products	product	NNS
cord-006229-7yoilsho	3590	24	or	or	CC
cord-006229-7yoilsho	3590	25	so	so	RB
cord-006229-7yoilsho	3590	26	-	-	HYPH
cord-006229-7yoilsho	3590	27	called	call	VBN
cord-006229-7yoilsho	3590	28	non	non	NN
cord-006229-7yoilsho	3590	29	-	-	JJ
cord-006229-7yoilsho	3590	30	intentionally	intentionally	RB
cord-006229-7yoilsho	3590	31	added	add	VBN
cord-006229-7yoilsho	3590	32	substances	substance	NNS
cord-006229-7yoilsho	3590	33	(	(	-LRB-
cord-006229-7yoilsho	3590	34	NIAS	NIAS	NNP
cord-006229-7yoilsho	3590	35	)	)	-RRB-
cord-006229-7yoilsho	3590	36	can	can	MD
cord-006229-7yoilsho	3590	37	be	be	VB
cord-006229-7yoilsho	3590	38	part	part	NN
cord-006229-7yoilsho	3590	39	of	of	IN
cord-006229-7yoilsho	3590	40	the	the	DT
cord-006229-7yoilsho	3590	41	material	material	NN
cord-006229-7yoilsho	3590	42	,	,	,
cord-006229-7yoilsho	3590	43	among	among	IN
cord-006229-7yoilsho	3590	44	them	-PRON-	PRP
cord-006229-7yoilsho	3590	45	potentially	potentially	RB
cord-006229-7yoilsho	3590	46	harmful	harmful	JJ
cord-006229-7yoilsho	3590	47	substances	substance	NNS
cord-006229-7yoilsho	3590	48	.	.	.
cord-006229-7yoilsho	3591	1	In	in	IN
cord-006229-7yoilsho	3591	2	a	a	DT
cord-006229-7yoilsho	3591	3	first	first	JJ
cord-006229-7yoilsho	3591	4	step	step	NN
cord-006229-7yoilsho	3591	5	,	,	,
cord-006229-7yoilsho	3591	6	polymers	polymer	NNS
cord-006229-7yoilsho	3591	7	of	of	IN
cord-006229-7yoilsho	3591	8	consumer	consumer	NN
cord-006229-7yoilsho	3591	9	products	product	NNS
cord-006229-7yoilsho	3591	10	like	like	IN
cord-006229-7yoilsho	3591	11	flashlights	flashlight	NNS
cord-006229-7yoilsho	3591	12	or	or	CC
cord-006229-7yoilsho	3591	13	tools	tool	NNS
cord-006229-7yoilsho	3591	14	have	have	VBP
cord-006229-7yoilsho	3591	15	been	be	VBN
cord-006229-7yoilsho	3591	16	characterized	characterize	VBN
cord-006229-7yoilsho	3591	17	concerning	concern	VBG
cord-006229-7yoilsho	3591	18	additive	additive	NN
cord-006229-7yoilsho	3591	19	composition	composition	NN
cord-006229-7yoilsho	3591	20	.	.	.
cord-006229-7yoilsho	3592	1	Possible	possible	JJ
cord-006229-7yoilsho	3592	2	breakdown	breakdown	NN
cord-006229-7yoilsho	3592	3	products	product	NNS
cord-006229-7yoilsho	3592	4	were	be	VBD
cord-006229-7yoilsho	3592	5	identified	identify	VBN
cord-006229-7yoilsho	3592	6	by	by	IN
cord-006229-7yoilsho	3592	7	means	mean	NNS
cord-006229-7yoilsho	3592	8	of	of	IN
cord-006229-7yoilsho	3592	9	GC	GC	NNP
cord-006229-7yoilsho	3592	10	-	-	HYPH
cord-006229-7yoilsho	3592	11	MS	MS	NNP
cord-006229-7yoilsho	3592	12	/	/	SYM
cord-006229-7yoilsho	3592	13	MS	MS	NNP
cord-006229-7yoilsho	3592	14	or	or	CC
cord-006229-7yoilsho	3592	15	pyrolysis	pyrolysis	NN
cord-006229-7yoilsho	3592	16	-	-	HYPH
cord-006229-7yoilsho	3592	17	GC	GC	NNP
cord-006229-7yoilsho	3592	18	-	-	HYPH
cord-006229-7yoilsho	3592	19	MS	MS	NNP
cord-006229-7yoilsho	3592	20	.	.	.
cord-006229-7yoilsho	3593	1	We	-PRON-	PRP
cord-006229-7yoilsho	3593	2	focused	focus	VBD
cord-006229-7yoilsho	3593	3	on	on	IN
cord-006229-7yoilsho	3593	4	analytes	analyte	NNS
cord-006229-7yoilsho	3593	5	of	of	IN
cord-006229-7yoilsho	3593	6	toxicological	toxicological	JJ
cord-006229-7yoilsho	3593	7	relevance	relevance	NN
cord-006229-7yoilsho	3593	8	including	include	VBG
cord-006229-7yoilsho	3593	9	antioxidants	antioxidant	NNS
cord-006229-7yoilsho	3593	10	such	such	JJ
cord-006229-7yoilsho	3593	11	as	as	IN
cord-006229-7yoilsho	3593	12	N	n	CD
cord-006229-7yoilsho	3593	13	-	-	HYPH
cord-006229-7yoilsho	3593	14	phenyl-2-naphthylamine	phenyl-2-naphthylamine	NNP
cord-006229-7yoilsho	3593	15	(	(	-LRB-
cord-006229-7yoilsho	3593	16	Neozon	Neozon	NNP
cord-006229-7yoilsho	3593	17	D	D	NNP
cord-006229-7yoilsho	3593	18	)	)	-RRB-
cord-006229-7yoilsho	3593	19	,	,	,
cord-006229-7yoilsho	3593	20	which	which	WDT
cord-006229-7yoilsho	3593	21	is	be	VBZ
cord-006229-7yoilsho	3593	22	suspected	suspect	VBN
cord-006229-7yoilsho	3593	23	of	of	IN
cord-006229-7yoilsho	3593	24	causing	cause	VBG
cord-006229-7yoilsho	3593	25	cancer	cancer	NN
cord-006229-7yoilsho	3593	26	,	,	,
cord-006229-7yoilsho	3593	27	and	and	CC
cord-006229-7yoilsho	3593	28	on	on	IN
cord-006229-7yoilsho	3593	29	degradation	degradation	NN
cord-006229-7yoilsho	3593	30	products	product	NNS
cord-006229-7yoilsho	3593	31	like	like	IN
cord-006229-7yoilsho	3593	32	cresol	cresol	NNP
cord-006229-7yoilsho	3593	33	and	and	CC
cord-006229-7yoilsho	3593	34	its	-PRON-	PRP$
cord-006229-7yoilsho	3593	35	derivatives	derivative	NNS
cord-006229-7yoilsho	3593	36	(	(	-LRB-
cord-006229-7yoilsho	3593	37	e.g.	e.g.	RB
cord-006229-7yoilsho	3593	38	,	,	,
cord-006229-7yoilsho	3593	39	mesitol	mesitol	NNP
cord-006229-7yoilsho	3593	40	or	or	CC
cord-006229-7yoilsho	3593	41	2-tert	2-tert	CD
cord-006229-7yoilsho	3593	42	-	-	HYPH
cord-006229-7yoilsho	3593	43	butyl-4-methylphenol	butyl-4-methylphenol	NNP
cord-006229-7yoilsho	3593	44	)	)	-RRB-
cord-006229-7yoilsho	3593	45	.	.	.
cord-006229-7yoilsho	3594	1	Subsequently	subsequently	RB
cord-006229-7yoilsho	3594	2	,	,	,
cord-006229-7yoilsho	3594	3	analytes	analyte	NNS
cord-006229-7yoilsho	3594	4	of	of	IN
cord-006229-7yoilsho	3594	5	interest	interest	NN
cord-006229-7yoilsho	3594	6	were	be	VBD
cord-006229-7yoilsho	3594	7	brought	bring	VBN
cord-006229-7yoilsho	3594	8	into	into	IN
cord-006229-7yoilsho	3594	9	direct	direct	JJ
cord-006229-7yoilsho	3594	10	skin	skin	NN
cord-006229-7yoilsho	3594	11	contact	contact	NN
cord-006229-7yoilsho	3594	12	using	use	VBG
cord-006229-7yoilsho	3594	13	porcine	porcine	JJ
cord-006229-7yoilsho	3594	14	,	,	,
cord-006229-7yoilsho	3594	15	human	human	JJ
cord-006229-7yoilsho	3594	16	and	and	CC
cord-006229-7yoilsho	3594	17	artificial	artificial	JJ
cord-006229-7yoilsho	3594	18	skin	skin	NN
cord-006229-7yoilsho	3594	19	models	model	NNS
cord-006229-7yoilsho	3594	20	in	in	IN
cord-006229-7yoilsho	3594	21	the	the	DT
cord-006229-7yoilsho	3594	22	Franz	Franz	NNP
cord-006229-7yoilsho	3594	23	cell	cell	NN
cord-006229-7yoilsho	3594	24	chamber	chamber	NN
cord-006229-7yoilsho	3594	25	assay	assay	NN
cord-006229-7yoilsho	3594	26	.	.	.
cord-006229-7yoilsho	3595	1	The	the	DT
cord-006229-7yoilsho	3595	2	analytes	analyte	NNS
cord-006229-7yoilsho	3595	3	were	be	VBD
cord-006229-7yoilsho	3595	4	either	either	CC
cord-006229-7yoilsho	3595	5	followed	follow	VBN
cord-006229-7yoilsho	3595	6	up	up	RP
cord-006229-7yoilsho	3595	7	layer	layer	NN
cord-006229-7yoilsho	3595	8	by	by	IN
cord-006229-7yoilsho	3595	9	layer	layer	NN
cord-006229-7yoilsho	3595	10	using	use	VBG
cord-006229-7yoilsho	3595	11	tape	tape	NN
cord-006229-7yoilsho	3595	12	stripping	strip	VBG
cord-006229-7yoilsho	3595	13	or	or	CC
cord-006229-7yoilsho	3595	14	examined	examine	VBD
cord-006229-7yoilsho	3595	15	utilizing	utilize	VBG
cord-006229-7yoilsho	3595	16	cryo	cryo	NN
cord-006229-7yoilsho	3595	17	sections	section	NNS
cord-006229-7yoilsho	3595	18	.	.	.
cord-006229-7yoilsho	3596	1	For	for	IN
cord-006229-7yoilsho	3596	2	visualization	visualization	NN
cord-006229-7yoilsho	3596	3	purposes	purpose	NNS
cord-006229-7yoilsho	3596	4	,	,	,
cord-006229-7yoilsho	3596	5	analytical	analytical	JJ
cord-006229-7yoilsho	3596	6	evaluation	evaluation	NN
cord-006229-7yoilsho	3596	7	has	have	VBZ
cord-006229-7yoilsho	3596	8	been	be	VBN
cord-006229-7yoilsho	3596	9	completed	complete	VBN
cord-006229-7yoilsho	3596	10	by	by	IN
cord-006229-7yoilsho	3596	11	use	use	NN
cord-006229-7yoilsho	3596	12	of	of	IN
cord-006229-7yoilsho	3596	13	imaging	imaging	NN
cord-006229-7yoilsho	3596	14	techniques	technique	NNS
cord-006229-7yoilsho	3596	15	like	like	IN
cord-006229-7yoilsho	3596	16	HE	he	PRP
cord-006229-7yoilsho	3596	17	staining	stain	VBG
cord-006229-7yoilsho	3596	18	or	or	CC
cord-006229-7yoilsho	3596	19	ATR	ATR	NNP
cord-006229-7yoilsho	3596	20	-	-	HYPH
cord-006229-7yoilsho	3596	21	FTIR	FTIR	NNP
cord-006229-7yoilsho	3596	22	(	(	-LRB-
cord-006229-7yoilsho	3596	23	attenuated	attenuated	JJ
cord-006229-7yoilsho	3596	24	total	total	JJ
cord-006229-7yoilsho	3596	25	reflectance	reflectance	NN
cord-006229-7yoilsho	3596	26	Fourier	Fourier	NNP
cord-006229-7yoilsho	3596	27	transform	transform	VB
cord-006229-7yoilsho	3596	28	infrared	infrared	JJ
cord-006229-7yoilsho	3596	29	)	)	-RRB-
cord-006229-7yoilsho	3596	30	microscopy	microscopy	NN
cord-006229-7yoilsho	3596	31	.	.	.
cord-006229-7yoilsho	3597	1	The	the	DT
cord-006229-7yoilsho	3597	2	latter	latter	JJ
cord-006229-7yoilsho	3597	3	was	be	VBD
cord-006229-7yoilsho	3597	4	used	use	VBN
cord-006229-7yoilsho	3597	5	with	with	IN
cord-006229-7yoilsho	3597	6	intrinsic	intrinsic	JJ
cord-006229-7yoilsho	3597	7	markers	marker	NNS
cord-006229-7yoilsho	3597	8	for	for	IN
cord-006229-7yoilsho	3597	9	tissue	tissue	NN
cord-006229-7yoilsho	3597	10	specific	specific	JJ
cord-006229-7yoilsho	3597	11	distribution	distribution	NN
cord-006229-7yoilsho	3597	12	.	.	.
cord-006229-7yoilsho	3598	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	3598	2	project	project	NN
cord-006229-7yoilsho	3598	3	provides	provide	VBZ
cord-006229-7yoilsho	3598	4	evidence	evidence	NN
cord-006229-7yoilsho	3598	5	for	for	IN
cord-006229-7yoilsho	3598	6	the	the	DT
cord-006229-7yoilsho	3598	7	potential	potential	NN
cord-006229-7yoilsho	3598	8	of	of	IN
cord-006229-7yoilsho	3598	9	polymer	polymer	NN
cord-006229-7yoilsho	3598	10	components	component	NNS
cord-006229-7yoilsho	3598	11	to	to	TO
cord-006229-7yoilsho	3598	12	overcome	overcome	VB
cord-006229-7yoilsho	3598	13	the	the	DT
cord-006229-7yoilsho	3598	14	natural	natural	JJ
cord-006229-7yoilsho	3598	15	epidermal	epidermal	JJ
cord-006229-7yoilsho	3598	16	barrier	barrier	NN
cord-006229-7yoilsho	3598	17	and	and	CC
cord-006229-7yoilsho	3598	18	,	,	,
cord-006229-7yoilsho	3598	19	in	in	IN
cord-006229-7yoilsho	3598	20	part	part	NN
cord-006229-7yoilsho	3598	21	,	,	,
cord-006229-7yoilsho	3598	22	to	to	TO
cord-006229-7yoilsho	3598	23	enter	enter	VB
cord-006229-7yoilsho	3598	24	the	the	DT
cord-006229-7yoilsho	3598	25	viable	viable	JJ
cord-006229-7yoilsho	3598	26	layers	layer	NNS
cord-006229-7yoilsho	3598	27	of	of	IN
cord-006229-7yoilsho	3598	28	the	the	DT
cord-006229-7yoilsho	3598	29	epidermis	epidermis	NN
cord-006229-7yoilsho	3598	30	.	.	.
cord-006229-7yoilsho	3599	1	During	during	IN
cord-006229-7yoilsho	3599	2	skin	skin	NN
cord-006229-7yoilsho	3599	3	contact	contact	NN
cord-006229-7yoilsho	3599	4	with	with	IN
cord-006229-7yoilsho	3599	5	consumer	consumer	NN
cord-006229-7yoilsho	3599	6	products	product	NNS
cord-006229-7yoilsho	3599	7	several	several	JJ
cord-006229-7yoilsho	3599	8	substances	substance	NNS
cord-006229-7yoilsho	3599	9	migrate	migrate	VBP
cord-006229-7yoilsho	3599	10	out	out	IN
cord-006229-7yoilsho	3599	11	of	of	IN
cord-006229-7yoilsho	3599	12	the	the	DT
cord-006229-7yoilsho	3599	13	matrix	matrix	NN
cord-006229-7yoilsho	3599	14	and	and	CC
cord-006229-7yoilsho	3599	15	penetrate	penetrate	VB
cord-006229-7yoilsho	3599	16	the	the	DT
cord-006229-7yoilsho	3599	17	skin	skin	NN
cord-006229-7yoilsho	3599	18	,	,	,
cord-006229-7yoilsho	3599	19	among	among	IN
cord-006229-7yoilsho	3599	20	them	-PRON-	PRP
cord-006229-7yoilsho	3599	21	substances	substance	NNS
cord-006229-7yoilsho	3599	22	which	which	WDT
cord-006229-7yoilsho	3599	23	are	be	VBP
cord-006229-7yoilsho	3599	24	hazardous	hazardous	JJ
cord-006229-7yoilsho	3599	25	to	to	IN
cord-006229-7yoilsho	3599	26	health	health	NN
cord-006229-7yoilsho	3599	27	such	such	JJ
cord-006229-7yoilsho	3599	28	as	as	IN
cord-006229-7yoilsho	3599	29	Neozon	Neozon	NNP
cord-006229-7yoilsho	3599	30	D.	D.	NNP
cord-006229-7yoilsho	3599	31	Depending	Depending	NNP
cord-006229-7yoilsho	3599	32	on	on	IN
cord-006229-7yoilsho	3599	33	its	-PRON-	PRP$
cord-006229-7yoilsho	3599	34	dose	dose	NN
cord-006229-7yoilsho	3599	35	,	,	,
cord-006229-7yoilsho	3599	36	the	the	DT
cord-006229-7yoilsho	3599	37	blister	blister	NN
cord-006229-7yoilsho	3599	38	agent	agent	NN
cord-006229-7yoilsho	3599	39	sulfur	sulfur	NN
cord-006229-7yoilsho	3599	40	mustard	mustard	NN
cord-006229-7yoilsho	3599	41	(	(	-LRB-
cord-006229-7yoilsho	3599	42	SM	SM	NNP
cord-006229-7yoilsho	3599	43	)	)	-RRB-
cord-006229-7yoilsho	3599	44	may	may	MD
cord-006229-7yoilsho	3599	45	lead	lead	VB
cord-006229-7yoilsho	3599	46	to	to	IN
cord-006229-7yoilsho	3599	47	painful	painful	JJ
cord-006229-7yoilsho	3599	48	erythema	erythema	NN
cord-006229-7yoilsho	3599	49	,	,	,
cord-006229-7yoilsho	3599	50	blistering	blister	VBG
cord-006229-7yoilsho	3599	51	with	with	IN
cord-006229-7yoilsho	3599	52	complicated	complicated	JJ
cord-006229-7yoilsho	3599	53	wound	wound	NN
cord-006229-7yoilsho	3599	54	healing	healing	NN
cord-006229-7yoilsho	3599	55	,	,	,
cord-006229-7yoilsho	3599	56	pulmonary	pulmonary	JJ
cord-006229-7yoilsho	3599	57	edema	edema	NN
cord-006229-7yoilsho	3599	58	,	,	,
cord-006229-7yoilsho	3599	59	pulmonary	pulmonary	JJ
cord-006229-7yoilsho	3599	60	bleeding	bleeding	NN
cord-006229-7yoilsho	3599	61	and	and	CC
cord-006229-7yoilsho	3599	62	temporary	temporary	JJ
cord-006229-7yoilsho	3599	63	blindness	blindness	NN
cord-006229-7yoilsho	3599	64	.	.	.
cord-006229-7yoilsho	3600	1	SM	SM	NNP
cord-006229-7yoilsho	3600	2	is	be	VBZ
cord-006229-7yoilsho	3600	3	listed	list	VBN
cord-006229-7yoilsho	3600	4	as	as	IN
cord-006229-7yoilsho	3600	5	a	a	DT
cord-006229-7yoilsho	3600	6	schedule	schedule	NN
cord-006229-7yoilsho	3600	7	1	1	CD
cord-006229-7yoilsho	3600	8	chemical	chemical	NN
cord-006229-7yoilsho	3600	9	in	in	IN
cord-006229-7yoilsho	3600	10	the	the	DT
cord-006229-7yoilsho	3600	11	Chemical	Chemical	NNP
cord-006229-7yoilsho	3600	12	Weapons	Weapons	NNPS
cord-006229-7yoilsho	3600	13	Convention	Convention	NNP
cord-006229-7yoilsho	3600	14	and	and	CC
cord-006229-7yoilsho	3600	15	thus	thus	RB
cord-006229-7yoilsho	3600	16	its	-PRON-	PRP$
cord-006229-7yoilsho	3600	17	production	production	NN
cord-006229-7yoilsho	3600	18	,	,	,
cord-006229-7yoilsho	3600	19	stockpiling	stockpiling	NN
cord-006229-7yoilsho	3600	20	and	and	CC
cord-006229-7yoilsho	3600	21	use	use	NN
cord-006229-7yoilsho	3600	22	is	be	VBZ
cord-006229-7yoilsho	3600	23	prohibited	prohibit	VBN
cord-006229-7yoilsho	3600	24	.	.	.
cord-006229-7yoilsho	3601	1	SM	SM	NNP
cord-006229-7yoilsho	3601	2	still	still	RB
cord-006229-7yoilsho	3601	3	represents	represent	VBZ
cord-006229-7yoilsho	3601	4	a	a	DT
cord-006229-7yoilsho	3601	5	serious	serious	JJ
cord-006229-7yoilsho	3601	6	threat	threat	NN
cord-006229-7yoilsho	3601	7	for	for	IN
cord-006229-7yoilsho	3601	8	civilians	civilian	NNS
cord-006229-7yoilsho	3601	9	and	and	CC
cord-006229-7yoilsho	3601	10	military	military	JJ
cord-006229-7yoilsho	3601	11	forces	force	NNS
cord-006229-7yoilsho	3601	12	,	,	,
cord-006229-7yoilsho	3601	13	especially	especially	RB
cord-006229-7yoilsho	3601	14	in	in	IN
cord-006229-7yoilsho	3601	15	asymmetric	asymmetric	JJ
cord-006229-7yoilsho	3601	16	,	,	,
cord-006229-7yoilsho	3601	17	terroristic	terroristic	JJ
cord-006229-7yoilsho	3601	18	and	and	CC
cord-006229-7yoilsho	3601	19	accidental	accidental	JJ
cord-006229-7yoilsho	3601	20	scenarios	scenario	NNS
cord-006229-7yoilsho	3601	21	.	.	.
cord-006229-7yoilsho	3602	1	After	after	IN
cord-006229-7yoilsho	3602	2	exposure	exposure	NN
cord-006229-7yoilsho	3602	3	,	,	,
cord-006229-7yoilsho	3602	4	the	the	DT
cord-006229-7yoilsho	3602	5	highly	highly	RB
cord-006229-7yoilsho	3602	6	reactive	reactive	JJ
cord-006229-7yoilsho	3602	7	molecule	molecule	NN
cord-006229-7yoilsho	3602	8	alkylates	alkylate	VBZ
cord-006229-7yoilsho	3602	9	nucleophilic	nucleophilic	JJ
cord-006229-7yoilsho	3602	10	sites	site	NNS
cord-006229-7yoilsho	3602	11	in	in	IN
cord-006229-7yoilsho	3602	12	endogenous	endogenous	JJ
cord-006229-7yoilsho	3602	13	biomacromolecules	biomacromolecule	NNS
cord-006229-7yoilsho	3602	14	forming	form	VBG
cord-006229-7yoilsho	3602	15	the	the	DT
cord-006229-7yoilsho	3602	16	characteristic	characteristic	JJ
cord-006229-7yoilsho	3602	17	and	and	CC
cord-006229-7yoilsho	3602	18	stable	stable	JJ
cord-006229-7yoilsho	3602	19	hydroxyethylthioehtyl	hydroxyethylthioehtyl	NN
cord-006229-7yoilsho	3602	20	(	(	-LRB-
cord-006229-7yoilsho	3602	21	HETE	HETE	NNP
cord-006229-7yoilsho	3602	22	)	)	-RRB-
cord-006229-7yoilsho	3602	23	residue	residue	NN
cord-006229-7yoilsho	3602	24	.	.	.
cord-006229-7yoilsho	3603	1	Hence	hence	RB
cord-006229-7yoilsho	3603	2	,	,	,
cord-006229-7yoilsho	3603	3	bioanalytical	bioanalytical	JJ
cord-006229-7yoilsho	3603	4	methods	method	NNS
cord-006229-7yoilsho	3603	5	targeting	target	VBG
cord-006229-7yoilsho	3603	6	these	these	DT
cord-006229-7yoilsho	3603	7	s	s	NNS
cord-006229-7yoilsho	3603	8	adducts	adduct	NNS
cord-006229-7yoilsho	3603	9	in	in	IN
cord-006229-7yoilsho	3603	10	forensic	forensic	JJ
cord-006229-7yoilsho	3603	11	post	post	JJ
cord-006229-7yoilsho	3603	12	-	-	JJ
cord-006229-7yoilsho	3603	13	exposure	exposure	JJ
cord-006229-7yoilsho	3603	14	verification	verification	NN
cord-006229-7yoilsho	3603	15	analysis	analysis	NN
cord-006229-7yoilsho	3603	16	are	be	VBP
cord-006229-7yoilsho	3603	17	of	of	IN
cord-006229-7yoilsho	3603	18	high	high	JJ
cord-006229-7yoilsho	3603	19	interest	interest	NN
cord-006229-7yoilsho	3603	20	.	.	.
cord-006229-7yoilsho	3604	1	Herein	herein	RB
cord-006229-7yoilsho	3604	2	,	,	,
cord-006229-7yoilsho	3604	3	we	-PRON-	PRP
cord-006229-7yoilsho	3604	4	present	present	VBP
cord-006229-7yoilsho	3604	5	an	an	DT
cord-006229-7yoilsho	3604	6	optimized	optimize	VBN
cord-006229-7yoilsho	3604	7	,	,	,
cord-006229-7yoilsho	3604	8	accurate	accurate	JJ
cord-006229-7yoilsho	3604	9	and	and	CC
cord-006229-7yoilsho	3604	10	comparably	comparably	RB
cord-006229-7yoilsho	3604	11	simple	simple	JJ
cord-006229-7yoilsho	3604	12	method	method	NN
cord-006229-7yoilsho	3604	13	to	to	TO
cord-006229-7yoilsho	3604	14	detect	detect	VB
cord-006229-7yoilsho	3604	15	adducts	adduct	NNS
cord-006229-7yoilsho	3604	16	of	of	IN
cord-006229-7yoilsho	3604	17	SM	SM	NNP
cord-006229-7yoilsho	3604	18	and	and	CC
cord-006229-7yoilsho	3604	19	human	human	JJ
cord-006229-7yoilsho	3604	20	serum	serum	NN
cord-006229-7yoilsho	3604	21	albumin	albumin	NN
cord-006229-7yoilsho	3604	22	(	(	-LRB-
cord-006229-7yoilsho	3604	23	HSA	HSA	NNP
cord-006229-7yoilsho	3604	24	)	)	-RRB-
cord-006229-7yoilsho	3604	25	alkylated	alkylate	VBD
cord-006229-7yoilsho	3604	26	at	at	IN
cord-006229-7yoilsho	3604	27	its	-PRON-	PRP$
cord-006229-7yoilsho	3604	28	cysteine	cysteine	NN
cord-006229-7yoilsho	3604	29	34	34	CD
cord-006229-7yoilsho	3604	30	-residue	-residue	CD
cord-006229-7yoilsho	3604	31	.	.	.
cord-006229-7yoilsho	3605	1	Since	since	IN
cord-006229-7yoilsho	3605	2	albumin	albumin	NN
cord-006229-7yoilsho	3605	3	extraction	extraction	NN
cord-006229-7yoilsho	3605	4	from	from	IN
cord-006229-7yoilsho	3605	5	human	human	JJ
cord-006229-7yoilsho	3605	6	plasma	plasma	NN
cord-006229-7yoilsho	3605	7	is	be	VBZ
cord-006229-7yoilsho	3605	8	a	a	DT
cord-006229-7yoilsho	3605	9	time	time	NN
cord-006229-7yoilsho	3605	10	-	-	HYPH
cord-006229-7yoilsho	3605	11	consuming	consume	VBG
cord-006229-7yoilsho	3605	12	and	and	CC
cord-006229-7yoilsho	3605	13	expensive	expensive	JJ
cord-006229-7yoilsho	3605	14	step	step	NN
cord-006229-7yoilsho	3605	15	of	of	IN
cord-006229-7yoilsho	3605	16	an	an	DT
cord-006229-7yoilsho	3605	17	established	establish	VBN
cord-006229-7yoilsho	3605	18	procedure	procedure	NN
cord-006229-7yoilsho	3605	19	,	,	,
cord-006229-7yoilsho	3605	20	an	an	DT
cord-006229-7yoilsho	3605	21	alternative	alternative	JJ
cord-006229-7yoilsho	3605	22	method	method	NN
cord-006229-7yoilsho	3605	23	for	for	IN
cord-006229-7yoilsho	3605	24	direct	direct	JJ
cord-006229-7yoilsho	3605	25	proteolysis	proteolysis	NN
cord-006229-7yoilsho	3605	26	of	of	IN
cord-006229-7yoilsho	3605	27	human	human	JJ
cord-006229-7yoilsho	3605	28	plasma	plasma	NN
cord-006229-7yoilsho	3605	29	was	be	VBD
cord-006229-7yoilsho	3605	30	developed	develop	VBN
cord-006229-7yoilsho	3605	31	.	.	.
cord-006229-7yoilsho	3606	1	Plasma	plasma	NN
cord-006229-7yoilsho	3606	2	samples	sample	NNS
cord-006229-7yoilsho	3606	3	were	be	VBD
cord-006229-7yoilsho	3606	4	cleaved	cleave	VBN
cord-006229-7yoilsho	3606	5	directly	directly	RB
cord-006229-7yoilsho	3606	6	with	with	IN
cord-006229-7yoilsho	3606	7	pronase	pronase	NN
cord-006229-7yoilsho	3606	8	resulting	result	VBG
cord-006229-7yoilsho	3606	9	in	in	IN
cord-006229-7yoilsho	3606	10	the	the	DT
cord-006229-7yoilsho	3606	11	alkylated	alkylated	JJ
cord-006229-7yoilsho	3606	12	dipeptide	dipeptide	NN
cord-006229-7yoilsho	3606	13	HETE	HETE	NNP
cord-006229-7yoilsho	3606	14	-	-	HYPH
cord-006229-7yoilsho	3606	15	cysteine	cysteine	NN
cord-006229-7yoilsho	3606	16	-	-	HYPH
cord-006229-7yoilsho	3606	17	proline	proline	NN
cord-006229-7yoilsho	3606	18	(	(	-LRB-
cord-006229-7yoilsho	3606	19	HETE	HETE	NNP
cord-006229-7yoilsho	3606	20	-	-	HYPH
cord-006229-7yoilsho	3606	21	CP	CP	NNP
cord-006229-7yoilsho	3606	22	)	)	-RRB-
cord-006229-7yoilsho	3606	23	which	which	WDT
cord-006229-7yoilsho	3606	24	is	be	VBZ
cord-006229-7yoilsho	3606	25	detected	detect	VBN
cord-006229-7yoilsho	3606	26	by	by	IN
cord-006229-7yoilsho	3606	27	micro	micro	JJ
cord-006229-7yoilsho	3606	28	-	-	JJ
cord-006229-7yoilsho	3606	29	liquid	liquid	JJ
cord-006229-7yoilsho	3606	30	chromatography	chromatography	NN
cord-006229-7yoilsho	3606	31	-	-	HYPH
cord-006229-7yoilsho	3606	32	electrospray	electrospray	JJ
cord-006229-7yoilsho	3606	33	ionization	ionization	NN
cord-006229-7yoilsho	3606	34	high	high	JJ
cord-006229-7yoilsho	3606	35	-	-	HYPH
cord-006229-7yoilsho	3606	36	resolution	resolution	NN
cord-006229-7yoilsho	3606	37	tandem	tandem	JJ
cord-006229-7yoilsho	3606	38	-	-	HYPH
cord-006229-7yoilsho	3606	39	mass	mass	NN
cord-006229-7yoilsho	3606	40	spectrometry	spectrometry	NN
cord-006229-7yoilsho	3606	41	(	(	-LRB-
cord-006229-7yoilsho	3606	42	µLC	µLC	NNP
cord-006229-7yoilsho	3606	43	-	-	HYPH
cord-006229-7yoilsho	3606	44	ESI	ESI	NNP
cord-006229-7yoilsho	3606	45	HR	HR	NNP
cord-006229-7yoilsho	3606	46	MS	MS	NNP
cord-006229-7yoilsho	3606	47	/	/	SYM
cord-006229-7yoilsho	3606	48	MS	MS	NNP
cord-006229-7yoilsho	3606	49	)	)	-RRB-
cord-006229-7yoilsho	3606	50	.	.	.
cord-006229-7yoilsho	3607	1	In	in	IN
cord-006229-7yoilsho	3607	2	order	order	NN
cord-006229-7yoilsho	3607	3	to	to	TO
cord-006229-7yoilsho	3607	4	optimize	optimize	VB
cord-006229-7yoilsho	3607	5	reproducibility	reproducibility	NN
cord-006229-7yoilsho	3607	6	and	and	CC
cord-006229-7yoilsho	3607	7	yield	yield	NN
cord-006229-7yoilsho	3607	8	of	of	IN
cord-006229-7yoilsho	3607	9	proteolysis	proteolysis	NN
cord-006229-7yoilsho	3607	10	,	,	,
cord-006229-7yoilsho	3607	11	kinetics	kinetic	NNS
cord-006229-7yoilsho	3607	12	were	be	VBD
cord-006229-7yoilsho	3607	13	investigated	investigate	VBN
cord-006229-7yoilsho	3607	14	for	for	IN
cord-006229-7yoilsho	3607	15	different	different	JJ
cord-006229-7yoilsho	3607	16	kinds	kind	NNS
cord-006229-7yoilsho	3607	17	of	of	IN
cord-006229-7yoilsho	3607	18	plasma	plasma	NN
cord-006229-7yoilsho	3607	19	(	(	-LRB-
cord-006229-7yoilsho	3607	20	EDTA-	EDTA-	NNS
cord-006229-7yoilsho	3607	21	,	,	,
cord-006229-7yoilsho	3607	22	citrate	citrate	NN
cord-006229-7yoilsho	3607	23	-	-	:
cord-006229-7yoilsho	3607	24	and	and	CC
cord-006229-7yoilsho	3607	25	heparin-	heparin-	JJ
cord-006229-7yoilsho	3607	26	)	)	-RRB-
cord-006229-7yoilsho	3607	27	as	as	RB
cord-006229-7yoilsho	3607	28	well	well	RB
cord-006229-7yoilsho	3607	29	as	as	IN
cord-006229-7yoilsho	3607	30	serum	serum	NN
cord-006229-7yoilsho	3607	31	.	.	.
cord-006229-7yoilsho	3608	1	Two	two	CD
cord-006229-7yoilsho	3608	2	different	different	JJ
cord-006229-7yoilsho	3608	3	mass	mass	NN
cord-006229-7yoilsho	3608	4	spectrometers	spectrometer	NNS
cord-006229-7yoilsho	3608	5	,	,	,
cord-006229-7yoilsho	3608	6	a	a	DT
cord-006229-7yoilsho	3608	7	triple	triple	JJ
cord-006229-7yoilsho	3608	8	quadrupole	quadrupole	JJ
cord-006229-7yoilsho	3608	9	system	system	NN
cord-006229-7yoilsho	3608	10	(	(	-LRB-
cord-006229-7yoilsho	3608	11	4000	4000	CD
cord-006229-7yoilsho	3608	12	QTrap	QTrap	NNP
cord-006229-7yoilsho	3608	13	)	)	-RRB-
cord-006229-7yoilsho	3608	14	and	and	CC
cord-006229-7yoilsho	3608	15	a	a	DT
cord-006229-7yoilsho	3608	16	hybrid	hybrid	JJ
cord-006229-7yoilsho	3608	17	quadrupole	quadrupole	JJ
cord-006229-7yoilsho	3608	18	time	time	NN
cord-006229-7yoilsho	3608	19	-	-	HYPH
cord-006229-7yoilsho	3608	20	of	of	IN
cord-006229-7yoilsho	3608	21	-	-	HYPH
cord-006229-7yoilsho	3608	22	flight	flight	NN
cord-006229-7yoilsho	3608	23	instrument	instrument	NN
cord-006229-7yoilsho	3608	24	(	(	-LRB-
cord-006229-7yoilsho	3608	25	TT5600	tt5600	NN
cord-006229-7yoilsho	3608	26	+	+	CC
cord-006229-7yoilsho	3608	27	)	)	-RRB-
cord-006229-7yoilsho	3608	28	,	,	,
cord-006229-7yoilsho	3608	29	were	be	VBD
cord-006229-7yoilsho	3608	30	compared	compare	VBN
cord-006229-7yoilsho	3608	31	.	.	.
cord-006229-7yoilsho	3609	1	The	the	DT
cord-006229-7yoilsho	3609	2	latter	latter	JJ
cord-006229-7yoilsho	3609	3	one	one	NN
cord-006229-7yoilsho	3609	4	proved	prove	VBD
cord-006229-7yoilsho	3609	5	to	to	TO
cord-006229-7yoilsho	3609	6	be	be	VB
cord-006229-7yoilsho	3609	7	the	the	DT
cord-006229-7yoilsho	3609	8	more	more	RBR
cord-006229-7yoilsho	3609	9	selective	selective	JJ
cord-006229-7yoilsho	3609	10	and	and	CC
cord-006229-7yoilsho	3609	11	sensitive	sensitive	JJ
cord-006229-7yoilsho	3609	12	system	system	NN
cord-006229-7yoilsho	3609	13	.	.	.
cord-006229-7yoilsho	3610	1	The	the	DT
cord-006229-7yoilsho	3610	2	method	method	NN
cord-006229-7yoilsho	3610	3	was	be	VBD
cord-006229-7yoilsho	3610	4	successfully	successfully	RB
cord-006229-7yoilsho	3610	5	applied	apply	VBN
cord-006229-7yoilsho	3610	6	to	to	IN
cord-006229-7yoilsho	3610	7	in	in	FW
cord-006229-7yoilsho	3610	8	vitro	vitro	FW
cord-006229-7yoilsho	3610	9	and	and	CC
cord-006229-7yoilsho	3610	10	in	in	IN
cord-006229-7yoilsho	3610	11	vivo	vivo	NN
cord-006229-7yoilsho	3610	12	samples	sample	NNS
cord-006229-7yoilsho	3610	13	of	of	IN
cord-006229-7yoilsho	3610	14	real	real	JJ
cord-006229-7yoilsho	3610	15	cases	case	NNS
cord-006229-7yoilsho	3610	16	of	of	IN
cord-006229-7yoilsho	3610	17	SM	sm	NN
cord-006229-7yoilsho	3610	18	poisoning	poisoning	NN
cord-006229-7yoilsho	3610	19	.	.	.
cord-006229-7yoilsho	3611	1	Organophosphorus	Organophosphorus	NNP
cord-006229-7yoilsho	3611	2	compounds	compound	NNS
cord-006229-7yoilsho	3611	3	(	(	-LRB-
cord-006229-7yoilsho	3611	4	OP	OP	NNP
cord-006229-7yoilsho	3611	5	)	)	-RRB-
cord-006229-7yoilsho	3611	6	,	,	,
cord-006229-7yoilsho	3611	7	which	which	WDT
cord-006229-7yoilsho	3611	8	were	be	VBD
cord-006229-7yoilsho	3611	9	originally	originally	RB
cord-006229-7yoilsho	3611	10	intended	intend	VBN
cord-006229-7yoilsho	3611	11	to	to	TO
cord-006229-7yoilsho	3611	12	be	be	VB
cord-006229-7yoilsho	3611	13	used	use	VBN
cord-006229-7yoilsho	3611	14	as	as	IN
cord-006229-7yoilsho	3611	15	pesticides	pesticide	NNS
cord-006229-7yoilsho	3611	16	to	to	TO
cord-006229-7yoilsho	3611	17	increase	increase	VB
cord-006229-7yoilsho	3611	18	agricultural	agricultural	JJ
cord-006229-7yoilsho	3611	19	yields	yield	NNS
cord-006229-7yoilsho	3611	20	at	at	IN
cord-006229-7yoilsho	3611	21	the	the	DT
cord-006229-7yoilsho	3611	22	onset	onset	NN
cord-006229-7yoilsho	3611	23	of	of	IN
cord-006229-7yoilsho	3611	24	the	the	DT
cord-006229-7yoilsho	3611	25	20	20	CD
cord-006229-7yoilsho	3611	26	th	th	XX
cord-006229-7yoilsho	3611	27	century	century	NN
cord-006229-7yoilsho	3611	28	,	,	,
cord-006229-7yoilsho	3611	29	still	still	RB
cord-006229-7yoilsho	3611	30	represent	represent	VB
cord-006229-7yoilsho	3611	31	a	a	DT
cord-006229-7yoilsho	3611	32	considerable	considerable	JJ
cord-006229-7yoilsho	3611	33	threat	threat	NN
cord-006229-7yoilsho	3611	34	to	to	IN
cord-006229-7yoilsho	3611	35	human	human	JJ
cord-006229-7yoilsho	3611	36	health	health	NN
cord-006229-7yoilsho	3611	37	.	.	.
cord-006229-7yoilsho	3612	1	By	by	IN
cord-006229-7yoilsho	3612	2	irreversible	irreversible	JJ
cord-006229-7yoilsho	3612	3	inhibition	inhibition	NN
cord-006229-7yoilsho	3612	4	of	of	IN
cord-006229-7yoilsho	3612	5	acetylcholinesterase	acetylcholinesterase	NN
cord-006229-7yoilsho	3612	6	OP	op	NN
cord-006229-7yoilsho	3612	7	lead	lead	NN
cord-006229-7yoilsho	3612	8	to	to	IN
cord-006229-7yoilsho	3612	9	cholinergic	cholinergic	JJ
cord-006229-7yoilsho	3612	10	crisis	crisis	NN
cord-006229-7yoilsho	3612	11	due	due	JJ
cord-006229-7yoilsho	3612	12	to	to	IN
cord-006229-7yoilsho	3612	13	uncontrolled	uncontrolled	JJ
cord-006229-7yoilsho	3612	14	increase	increase	NN
cord-006229-7yoilsho	3612	15	of	of	IN
cord-006229-7yoilsho	3612	16	acetylcholine	acetylcholine	NN
cord-006229-7yoilsho	3612	17	in	in	IN
cord-006229-7yoilsho	3612	18	the	the	DT
cord-006229-7yoilsho	3612	19	synaptic	synaptic	JJ
cord-006229-7yoilsho	3612	20	cleft	cleft	NN
cord-006229-7yoilsho	3612	21	.	.	.
cord-006229-7yoilsho	3613	1	Finally	finally	RB
cord-006229-7yoilsho	3613	2	,	,	,
cord-006229-7yoilsho	3613	3	sudden	sudden	JJ
cord-006229-7yoilsho	3613	4	death	death	NN
cord-006229-7yoilsho	3613	5	by	by	IN
cord-006229-7yoilsho	3613	6	respiratory	respiratory	JJ
cord-006229-7yoilsho	3613	7	failure	failure	NN
cord-006229-7yoilsho	3613	8	may	may	MD
cord-006229-7yoilsho	3613	9	result	result	VB
cord-006229-7yoilsho	3613	10	if	if	IN
cord-006229-7yoilsho	3613	11	medical	medical	JJ
cord-006229-7yoilsho	3613	12	countermeasures	countermeasure	NNS
cord-006229-7yoilsho	3613	13	are	be	VBP
cord-006229-7yoilsho	3613	14	lacking	lack	VBG
cord-006229-7yoilsho	3613	15	.	.	.
cord-006229-7yoilsho	3614	1	Therefore	therefore	RB
cord-006229-7yoilsho	3614	2	exceptionally	exceptionally	RB
cord-006229-7yoilsho	3614	3	toxic	toxic	JJ
cord-006229-7yoilsho	3614	4	compounds	compound	NNS
cord-006229-7yoilsho	3614	5	were	be	VBD
cord-006229-7yoilsho	3614	6	designed	design	VBN
cord-006229-7yoilsho	3614	7	und	und	RB
cord-006229-7yoilsho	3614	8	synthesized	synthesize	VBN
cord-006229-7yoilsho	3614	9	as	as	IN
cord-006229-7yoilsho	3614	10	chemical	chemical	JJ
cord-006229-7yoilsho	3614	11	warfare	warfare	NN
cord-006229-7yoilsho	3614	12	agents	agent	NNS
cord-006229-7yoilsho	3614	13	(	(	-LRB-
cord-006229-7yoilsho	3614	14	CWA	CWA	NNP
cord-006229-7yoilsho	3614	15	)	)	-RRB-
cord-006229-7yoilsho	3614	16	,	,	,
cord-006229-7yoilsho	3614	17	among	among	IN
cord-006229-7yoilsho	3614	18	which	which	WDT
cord-006229-7yoilsho	3614	19	V	v	NN
cord-006229-7yoilsho	3614	20	-	-	HYPH
cord-006229-7yoilsho	3614	21	type	type	NN
cord-006229-7yoilsho	3614	22	nerve	nerve	NN
cord-006229-7yoilsho	3614	23	agents	agent	NNS
cord-006229-7yoilsho	3614	24	,	,	,
cord-006229-7yoilsho	3614	25	i.e.	i.e.	FW
cord-006229-7yoilsho	3614	26	VX	vx	NN
cord-006229-7yoilsho	3614	27	,	,	,
cord-006229-7yoilsho	3614	28	Chinese	chinese	JJ
cord-006229-7yoilsho	3614	29	VX	vx	NN
cord-006229-7yoilsho	3614	30	and	and	CC
cord-006229-7yoilsho	3614	31	Russian	russian	JJ
cord-006229-7yoilsho	3614	32	VX	vx	NN
cord-006229-7yoilsho	3614	33	,	,	,
cord-006229-7yoilsho	3614	34	belong	belong	VBP
cord-006229-7yoilsho	3614	35	to	to	IN
cord-006229-7yoilsho	3614	36	the	the	DT
cord-006229-7yoilsho	3614	37	most	most	RBS
cord-006229-7yoilsho	3614	38	toxic	toxic	JJ
cord-006229-7yoilsho	3614	39	artificial	artificial	JJ
cord-006229-7yoilsho	3614	40	substances	substance	NNS
cord-006229-7yoilsho	3614	41	.	.	.
cord-006229-7yoilsho	3615	1	Recent	recent	JJ
cord-006229-7yoilsho	3615	2	events	event	NNS
cord-006229-7yoilsho	3615	3	like	like	IN
cord-006229-7yoilsho	3615	4	the	the	DT
cord-006229-7yoilsho	3615	5	First	First	NNP
cord-006229-7yoilsho	3615	6	Gulf	Gulf	NNP
cord-006229-7yoilsho	3615	7	War	War	NNP
cord-006229-7yoilsho	3615	8	,	,	,
cord-006229-7yoilsho	3615	9	terrorist	terrorist	JJ
cord-006229-7yoilsho	3615	10	attacks	attack	NNS
cord-006229-7yoilsho	3615	11	in	in	IN
cord-006229-7yoilsho	3615	12	Tokyo	Tokyo	NNP
cord-006229-7yoilsho	3615	13	and	and	CC
cord-006229-7yoilsho	3615	14	the	the	DT
cord-006229-7yoilsho	3615	15	conflict	conflict	NN
cord-006229-7yoilsho	3615	16	in	in	IN
cord-006229-7yoilsho	3615	17	Syria	Syria	NNP
cord-006229-7yoilsho	3615	18	underline	underline	VB
cord-006229-7yoilsho	3615	19	the	the	DT
cord-006229-7yoilsho	3615	20	need	need	NN
cord-006229-7yoilsho	3615	21	for	for	IN
cord-006229-7yoilsho	3615	22	ongoing	ongoing	JJ
cord-006229-7yoilsho	3615	23	and	and	CC
cord-006229-7yoilsho	3615	24	strict	strict	JJ
cord-006229-7yoilsho	3615	25	surveillance	surveillance	NN
cord-006229-7yoilsho	3615	26	of	of	IN
cord-006229-7yoilsho	3615	27	CWA	CWA	NNP
cord-006229-7yoilsho	3615	28	prohibition	prohibition	NN
cord-006229-7yoilsho	3615	29	by	by	IN
cord-006229-7yoilsho	3615	30	the	the	DT
cord-006229-7yoilsho	3615	31	Chemical	Chemical	NNP
cord-006229-7yoilsho	3615	32	Weapons	Weapons	NNPS
cord-006229-7yoilsho	3615	33	Convention	Convention	NNP
cord-006229-7yoilsho	3615	34	.	.	.
cord-006229-7yoilsho	3616	1	Unambiguous	unambiguous	JJ
cord-006229-7yoilsho	3616	2	evidence	evidence	NN
cord-006229-7yoilsho	3616	3	of	of	IN
cord-006229-7yoilsho	3616	4	such	such	JJ
cord-006229-7yoilsho	3616	5	substances	substance	NNS
cord-006229-7yoilsho	3616	6	(	(	-LRB-
cord-006229-7yoilsho	3616	7	verification	verification	NN
cord-006229-7yoilsho	3616	8	analysis	analysis	NN
cord-006229-7yoilsho	3616	9	)	)	-RRB-
cord-006229-7yoilsho	3616	10	plays	play	VBZ
cord-006229-7yoilsho	3616	11	an	an	DT
cord-006229-7yoilsho	3616	12	important	important	JJ
cord-006229-7yoilsho	3616	13	role	role	NN
cord-006229-7yoilsho	3616	14	with	with	IN
cord-006229-7yoilsho	3616	15	great	great	JJ
cord-006229-7yoilsho	3616	16	political	political	JJ
cord-006229-7yoilsho	3616	17	and	and	CC
cord-006229-7yoilsho	3616	18	legal	legal	JJ
cord-006229-7yoilsho	3616	19	impact	impact	NN
cord-006229-7yoilsho	3616	20	.	.	.
cord-006229-7yoilsho	3617	1	A	a	DT
cord-006229-7yoilsho	3617	2	variety	variety	NN
cord-006229-7yoilsho	3617	3	of	of	IN
cord-006229-7yoilsho	3617	4	such	such	JJ
cord-006229-7yoilsho	3617	5	bioanalytical	bioanalytical	JJ
cord-006229-7yoilsho	3617	6	methods	method	NNS
cord-006229-7yoilsho	3617	7	have	have	VBP
cord-006229-7yoilsho	3617	8	been	be	VBN
cord-006229-7yoilsho	3617	9	established	establish	VBN
cord-006229-7yoilsho	3617	10	at	at	IN
cord-006229-7yoilsho	3617	11	the	the	DT
cord-006229-7yoilsho	3617	12	Bundeswehr	Bundeswehr	NNP
cord-006229-7yoilsho	3617	13	Institute	Institute	NNP
cord-006229-7yoilsho	3617	14	of	of	IN
cord-006229-7yoilsho	3617	15	Pharmacology	Pharmacology	NNP
cord-006229-7yoilsho	3617	16	and	and	CC
cord-006229-7yoilsho	3617	17	Toxicology	Toxicology	NNP
cord-006229-7yoilsho	3617	18	in	in	IN
cord-006229-7yoilsho	3617	19	Munich	Munich	NNP
cord-006229-7yoilsho	3617	20	,	,	,
cord-006229-7yoilsho	3617	21	which	which	WDT
cord-006229-7yoilsho	3617	22	is	be	VBZ
cord-006229-7yoilsho	3617	23	accounted	account	VBN
cord-006229-7yoilsho	3617	24	for	for	IN
cord-006229-7yoilsho	3617	25	medical	medical	JJ
cord-006229-7yoilsho	3617	26	chemical	chemical	NN
cord-006229-7yoilsho	3617	27	defence	defence	NN
cord-006229-7yoilsho	3617	28	in	in	IN
cord-006229-7yoilsho	3617	29	Germany	Germany	NNP
cord-006229-7yoilsho	3617	30	.	.	.
cord-006229-7yoilsho	3618	1	Exhibiting	exhibit	VBG
cord-006229-7yoilsho	3618	2	quite	quite	RB
cord-006229-7yoilsho	3618	3	short	short	JJ
cord-006229-7yoilsho	3618	4	half	half	RB
cord-006229-7yoilsho	3618	5	-	-	HYPH
cord-006229-7yoilsho	3618	6	lives	life	NNS
cord-006229-7yoilsho	3618	7	in	in	IN
cord-006229-7yoilsho	3618	8	vivo	vivo	NN
cord-006229-7yoilsho	3618	9	nerve	nerve	NN
cord-006229-7yoilsho	3618	10	agents	agent	NNS
cord-006229-7yoilsho	3618	11	can	can	MD
cord-006229-7yoilsho	3618	12	hardly	hardly	RB
cord-006229-7yoilsho	3618	13	be	be	VB
cord-006229-7yoilsho	3618	14	detected	detect	VBN
cord-006229-7yoilsho	3618	15	days	day	NNS
cord-006229-7yoilsho	3618	16	or	or	CC
cord-006229-7yoilsho	3618	17	even	even	RB
cord-006229-7yoilsho	3618	18	weeks	week	NNS
cord-006229-7yoilsho	3618	19	after	after	IN
cord-006229-7yoilsho	3618	20	exposure	exposure	NN
cord-006229-7yoilsho	3618	21	.	.	.
cord-006229-7yoilsho	3619	1	Accordingly	accordingly	RB
cord-006229-7yoilsho	3619	2	,	,	,
cord-006229-7yoilsho	3619	3	there	there	EX
cord-006229-7yoilsho	3619	4	is	be	VBZ
cord-006229-7yoilsho	3619	5	a	a	DT
cord-006229-7yoilsho	3619	6	great	great	JJ
cord-006229-7yoilsho	3619	7	need	need	NN
cord-006229-7yoilsho	3619	8	for	for	IN
cord-006229-7yoilsho	3619	9	additional	additional	JJ
cord-006229-7yoilsho	3619	10	long	long	JJ
cord-006229-7yoilsho	3619	11	-	-	HYPH
cord-006229-7yoilsho	3619	12	term	term	NN
cord-006229-7yoilsho	3619	13	biomarkers	biomarker	NNS
cord-006229-7yoilsho	3619	14	like	like	IN
cord-006229-7yoilsho	3619	15	specific	specific	JJ
cord-006229-7yoilsho	3619	16	protein	protein	NN
cord-006229-7yoilsho	3619	17	adducts	adduct	NNS
cord-006229-7yoilsho	3619	18	.	.	.
cord-006229-7yoilsho	3620	1	Consequently	consequently	RB
cord-006229-7yoilsho	3620	2	,	,	,
cord-006229-7yoilsho	3620	3	the	the	DT
cord-006229-7yoilsho	3620	4	current	current	JJ
cord-006229-7yoilsho	3620	5	work	work	NN
cord-006229-7yoilsho	3620	6	focuses	focus	VBZ
cord-006229-7yoilsho	3620	7	on	on	IN
cord-006229-7yoilsho	3620	8	examination	examination	NN
cord-006229-7yoilsho	3620	9	of	of	IN
cord-006229-7yoilsho	3620	10	adducts	adduct	NNS
cord-006229-7yoilsho	3620	11	between	between	IN
cord-006229-7yoilsho	3620	12	nerve	nerve	NN
cord-006229-7yoilsho	3620	13	agents	agent	NNS
cord-006229-7yoilsho	3620	14	and	and	CC
cord-006229-7yoilsho	3620	15	human	human	JJ
cord-006229-7yoilsho	3620	16	serum	serum	NN
cord-006229-7yoilsho	3620	17	albumin	albumin	NN
cord-006229-7yoilsho	3620	18	(	(	-LRB-
cord-006229-7yoilsho	3620	19	HSA	HSA	NNP
cord-006229-7yoilsho	3620	20	)	)	-RRB-
cord-006229-7yoilsho	3620	21	as	as	IN
cord-006229-7yoilsho	3620	22	its	-PRON-	PRP$
cord-006229-7yoilsho	3620	23	high	high	JJ
cord-006229-7yoilsho	3620	24	abundance	abundance	NN
cord-006229-7yoilsho	3620	25	and	and	CC
cord-006229-7yoilsho	3620	26	stability	stability	NN
cord-006229-7yoilsho	3620	27	in	in	IN
cord-006229-7yoilsho	3620	28	vivo	vivo	NN
cord-006229-7yoilsho	3620	29	provide	provide	VBP
cord-006229-7yoilsho	3620	30	relative	relative	JJ
cord-006229-7yoilsho	3620	31	ease	ease	NN
cord-006229-7yoilsho	3620	32	of	of	IN
cord-006229-7yoilsho	3620	33	sampling	sampling	NN
cord-006229-7yoilsho	3620	34	.	.	.
cord-006229-7yoilsho	3621	1	After	after	IN
cord-006229-7yoilsho	3621	2	incubation	incubation	NN
cord-006229-7yoilsho	3621	3	of	of	IN
cord-006229-7yoilsho	3621	4	HSA	HSA	NNP
cord-006229-7yoilsho	3621	5	with	with	IN
cord-006229-7yoilsho	3621	6	V	v	NN
cord-006229-7yoilsho	3621	7	-	-	HYPH
cord-006229-7yoilsho	3621	8	type	type	NN
cord-006229-7yoilsho	3621	9	nerve	nerve	NN
cord-006229-7yoilsho	3621	10	agents	agent	NNS
cord-006229-7yoilsho	3621	11	in	in	IN
cord-006229-7yoilsho	3621	12	vitro	vitro	FW
cord-006229-7yoilsho	3621	13	the	the	DT
cord-006229-7yoilsho	3621	14	protein	protein	NN
cord-006229-7yoilsho	3621	15	was	be	VBD
cord-006229-7yoilsho	3621	16	subjected	subject	VBN
cord-006229-7yoilsho	3621	17	to	to	IN
cord-006229-7yoilsho	3621	18	proteolysis	proteolysis	NN
cord-006229-7yoilsho	3621	19	.	.	.
cord-006229-7yoilsho	3622	1	Subsequently	subsequently	RB
cord-006229-7yoilsho	3622	2	resulting	result	VBG
cord-006229-7yoilsho	3622	3	peptides	peptide	NNS
cord-006229-7yoilsho	3622	4	were	be	VBD
cord-006229-7yoilsho	3622	5	separated	separate	VBN
cord-006229-7yoilsho	3622	6	using	use	VBG
cord-006229-7yoilsho	3622	7	microbore	microbore	NN
cord-006229-7yoilsho	3622	8	high	high	JJ
cord-006229-7yoilsho	3622	9	-	-	HYPH
cord-006229-7yoilsho	3622	10	performance	performance	NN
cord-006229-7yoilsho	3622	11	liquid	liquid	NN
cord-006229-7yoilsho	3622	12	chromatography	chromatography	NN
cord-006229-7yoilsho	3622	13	(	(	-LRB-
cord-006229-7yoilsho	3622	14	µLC	µLC	NNP
cord-006229-7yoilsho	3622	15	)	)	-RRB-
cord-006229-7yoilsho	3622	16	and	and	CC
cord-006229-7yoilsho	3622	17	detected	detect	VBD
cord-006229-7yoilsho	3622	18	on	on	IN
cord-006229-7yoilsho	3622	19	-	-	HYPH
cord-006229-7yoilsho	3622	20	line	line	NN
cord-006229-7yoilsho	3622	21	by	by	IN
cord-006229-7yoilsho	3622	22	modern	modern	JJ
cord-006229-7yoilsho	3622	23	high	high	JJ
cord-006229-7yoilsho	3622	24	-	-	HYPH
cord-006229-7yoilsho	3622	25	resolution	resolution	NN
cord-006229-7yoilsho	3622	26	tandemmass	tandemmass	NN
cord-006229-7yoilsho	3622	27	spectrometry	spectrometry	NN
cord-006229-7yoilsho	3622	28	(	(	-LRB-
cord-006229-7yoilsho	3622	29	HR	HR	NNP
cord-006229-7yoilsho	3622	30	MS	MS	NNP
cord-006229-7yoilsho	3622	31	/	/	SYM
cord-006229-7yoilsho	3622	32	MS	MS	NNP
cord-006229-7yoilsho	3622	33	)	)	-RRB-
cord-006229-7yoilsho	3622	34	.	.	.
cord-006229-7yoilsho	3623	1	This	this	DT
cord-006229-7yoilsho	3623	2	allowed	allow	VBD
cord-006229-7yoilsho	3623	3	unambiguous	unambiguous	JJ
cord-006229-7yoilsho	3623	4	identification	identification	NN
cord-006229-7yoilsho	3623	5	of	of	IN
cord-006229-7yoilsho	3623	6	already	already	RB
cord-006229-7yoilsho	3623	7	known	know	VBN
cord-006229-7yoilsho	3623	8	phosphylated	phosphylate	VBN
cord-006229-7yoilsho	3623	9	tyrosines	tyrosines	NNP
cord-006229-7yoilsho	3623	10	as	as	RB
cord-006229-7yoilsho	3623	11	well	well	RB
cord-006229-7yoilsho	3623	12	as	as	IN
cord-006229-7yoilsho	3623	13	novel	novel	JJ
cord-006229-7yoilsho	3623	14	adducts	adduct	NNS
cord-006229-7yoilsho	3623	15	between	between	IN
cord-006229-7yoilsho	3623	16	cysteine	cysteine	NN
cord-006229-7yoilsho	3623	17	-	-	HYPH
cord-006229-7yoilsho	3623	18	proline	proline	NN
cord-006229-7yoilsho	3623	19	dipeptides	dipeptide	NNS
cord-006229-7yoilsho	3623	20	and	and	CC
cord-006229-7yoilsho	3623	21	the	the	DT
cord-006229-7yoilsho	3623	22	thiol	thiol	NN
cord-006229-7yoilsho	3623	23	-	-	HYPH
cord-006229-7yoilsho	3623	24	containing	contain	VBG
cord-006229-7yoilsho	3623	25	leaving	leave	VBG
cord-006229-7yoilsho	3623	26	group	group	NN
cord-006229-7yoilsho	3623	27	of	of	IN
cord-006229-7yoilsho	3623	28	V	v	NN
cord-006229-7yoilsho	3623	29	-	-	HYPH
cord-006229-7yoilsho	3623	30	type	type	NN
cord-006229-7yoilsho	3623	31	nerve	nerve	NN
cord-006229-7yoilsho	3623	32	agents	agent	NNS
cord-006229-7yoilsho	3623	33	.	.	.
cord-006229-7yoilsho	3624	1	Simultaneous	simultaneous	JJ
cord-006229-7yoilsho	3624	2	detection	detection	NN
cord-006229-7yoilsho	3624	3	of	of	IN
cord-006229-7yoilsho	3624	4	both	both	DT
cord-006229-7yoilsho	3624	5	biomarkers	biomarker	NNS
cord-006229-7yoilsho	3624	6	was	be	VBD
cord-006229-7yoilsho	3624	7	realized	realize	VBN
cord-006229-7yoilsho	3624	8	by	by	IN
cord-006229-7yoilsho	3624	9	a	a	DT
cord-006229-7yoilsho	3624	10	new	new	JJ
cord-006229-7yoilsho	3624	11	method	method	NN
cord-006229-7yoilsho	3624	12	,	,	,
cord-006229-7yoilsho	3624	13	which	which	WDT
cord-006229-7yoilsho	3624	14	was	be	VBD
cord-006229-7yoilsho	3624	15	applicable	applicable	JJ
cord-006229-7yoilsho	3624	16	even	even	RB
cord-006229-7yoilsho	3624	17	at	at	IN
cord-006229-7yoilsho	3624	18	the	the	DT
cord-006229-7yoilsho	3624	19	very	very	RB
cord-006229-7yoilsho	3624	20	low	low	JJ
cord-006229-7yoilsho	3624	21	toxicologically	toxicologically	RB
cord-006229-7yoilsho	3624	22	relevant	relevant	JJ
cord-006229-7yoilsho	3624	23	concentrations	concentration	NNS
cord-006229-7yoilsho	3624	24	of	of	IN
cord-006229-7yoilsho	3624	25	V	v	NN
cord-006229-7yoilsho	3624	26	-	-	HYPH
cord-006229-7yoilsho	3624	27	type	type	NN
cord-006229-7yoilsho	3624	28	agents	agent	NNS
cord-006229-7yoilsho	3624	29	.	.	.
cord-006229-7yoilsho	3625	1	Therefore	therefore	RB
cord-006229-7yoilsho	3625	2	,	,	,
cord-006229-7yoilsho	3625	3	this	this	DT
cord-006229-7yoilsho	3625	4	method	method	NN
cord-006229-7yoilsho	3625	5	represents	represent	VBZ
cord-006229-7yoilsho	3625	6	a	a	DT
cord-006229-7yoilsho	3625	7	valuable	valuable	JJ
cord-006229-7yoilsho	3625	8	and	and	CC
cord-006229-7yoilsho	3625	9	novel	novel	JJ
cord-006229-7yoilsho	3625	10	supplement	supplement	NN
cord-006229-7yoilsho	3625	11	of	of	IN
cord-006229-7yoilsho	3625	12	existing	exist	VBG
cord-006229-7yoilsho	3625	13	methods	method	NNS
cord-006229-7yoilsho	3625	14	for	for	IN
cord-006229-7yoilsho	3625	15	verification	verification	NN
cord-006229-7yoilsho	3625	16	.	.	.
cord-006229-7yoilsho	3626	1	Fatty	fatty	JJ
cord-006229-7yoilsho	3626	2	acid	acid	NN
cord-006229-7yoilsho	3626	3	esters	ester	NNS
cord-006229-7yoilsho	3626	4	of	of	IN
cord-006229-7yoilsho	3626	5	glycidol	glycidol	NNP
cord-006229-7yoilsho	3626	6	(	(	-LRB-
cord-006229-7yoilsho	3626	7	glycidyl	glycidyl	NNP
cord-006229-7yoilsho	3626	8	esters	esters	NNP
cord-006229-7yoilsho	3626	9	)	)	-RRB-
cord-006229-7yoilsho	3627	1	are	be	VBP
cord-006229-7yoilsho	3627	2	processing	process	VBG
cord-006229-7yoilsho	3627	3	contaminants	contaminant	NNS
cord-006229-7yoilsho	3627	4	formed	form	VBN
cord-006229-7yoilsho	3627	5	as	as	IN
cord-006229-7yoilsho	3627	6	byproducts	byproduct	NNS
cord-006229-7yoilsho	3627	7	of	of	IN
cord-006229-7yoilsho	3627	8	industrial	industrial	JJ
cord-006229-7yoilsho	3627	9	deodorizing	deodorizing	NN
cord-006229-7yoilsho	3627	10	of	of	IN
cord-006229-7yoilsho	3627	11	plant	plant	NN
cord-006229-7yoilsho	3627	12	fats	fat	NNS
cord-006229-7yoilsho	3627	13	or	or	CC
cord-006229-7yoilsho	3627	14	during	during	IN
cord-006229-7yoilsho	3627	15	other	other	JJ
cord-006229-7yoilsho	3627	16	heating	heating	NN
cord-006229-7yoilsho	3627	17	processes	process	NNS
cord-006229-7yoilsho	3627	18	.	.	.
cord-006229-7yoilsho	3628	1	Following	follow	VBG
cord-006229-7yoilsho	3628	2	oral	oral	JJ
cord-006229-7yoilsho	3628	3	intake	intake	NN
cord-006229-7yoilsho	3628	4	,	,	,
cord-006229-7yoilsho	3628	5	glycidyl	glycidyl	NNP
cord-006229-7yoilsho	3628	6	esters	ester	NNS
cord-006229-7yoilsho	3628	7	are	be	VBP
cord-006229-7yoilsho	3628	8	mainly	mainly	RB
cord-006229-7yoilsho	3628	9	cleaved	cleave	VBN
cord-006229-7yoilsho	3628	10	to	to	TO
cord-006229-7yoilsho	3628	11	release	release	VB
cord-006229-7yoilsho	3628	12	the	the	DT
cord-006229-7yoilsho	3628	13	reactive	reactive	JJ
cord-006229-7yoilsho	3628	14	glycidol	glycidol	NN
cord-006229-7yoilsho	3628	15	in	in	IN
cord-006229-7yoilsho	3628	16	the	the	DT
cord-006229-7yoilsho	3628	17	gastrointestinal	gastrointestinal	JJ
cord-006229-7yoilsho	3628	18	tract	tract	NN
cord-006229-7yoilsho	3628	19	.	.	.
cord-006229-7yoilsho	3629	1	According	accord	VBG
cord-006229-7yoilsho	3629	2	to	to	IN
cord-006229-7yoilsho	3629	3	the	the	DT
cord-006229-7yoilsho	3629	4	National	National	NNP
cord-006229-7yoilsho	3629	5	Toxicology	Toxicology	NNP
cord-006229-7yoilsho	3629	6	Program	Program	NNP
cord-006229-7yoilsho	3629	7	(	(	-LRB-
cord-006229-7yoilsho	3629	8	NTP	NTP	NNP
cord-006229-7yoilsho	3629	9	)	)	-RRB-
cord-006229-7yoilsho	3629	10	,	,	,
cord-006229-7yoilsho	3629	11	glycidol	glycidol	NNP
cord-006229-7yoilsho	3629	12	is	be	VBZ
cord-006229-7yoilsho	3629	13	carcinogenic	carcinogenic	JJ
cord-006229-7yoilsho	3629	14	,	,	,
cord-006229-7yoilsho	3629	15	genotoxic	genotoxic	JJ
cord-006229-7yoilsho	3629	16	and	and	CC
cord-006229-7yoilsho	3629	17	teratogenic	teratogenic	JJ
cord-006229-7yoilsho	3629	18	in	in	IN
cord-006229-7yoilsho	3629	19	rodents	rodent	NNS
cord-006229-7yoilsho	3629	20	.	.	.
cord-006229-7yoilsho	3630	1	It	-PRON-	PRP
cord-006229-7yoilsho	3630	2	is	be	VBZ
cord-006229-7yoilsho	3630	3	classified	classify	VBN
cord-006229-7yoilsho	3630	4	as	as	IN
cord-006229-7yoilsho	3630	5	probably	probably	RB
cord-006229-7yoilsho	3630	6	carcinogenic	carcinogenic	JJ
cord-006229-7yoilsho	3630	7	to	to	IN
cord-006229-7yoilsho	3630	8	humans	human	NNS
cord-006229-7yoilsho	3630	9	(	(	-LRB-
cord-006229-7yoilsho	3630	10	IARC	IARC	NNP
cord-006229-7yoilsho	3630	11	group	group	NN
cord-006229-7yoilsho	3630	12	2A	2a	CD
cord-006229-7yoilsho	3630	13	)	)	-RRB-
cord-006229-7yoilsho	3630	14	.	.	.
cord-006229-7yoilsho	3631	1	The	the	DT
cord-006229-7yoilsho	3631	2	exposure	exposure	NN
cord-006229-7yoilsho	3631	3	assessment	assessment	NN
cord-006229-7yoilsho	3631	4	of	of	IN
cord-006229-7yoilsho	3631	5	the	the	DT
cord-006229-7yoilsho	3631	6	oral	oral	JJ
cord-006229-7yoilsho	3631	7	intake	intake	NN
cord-006229-7yoilsho	3631	8	of	of	IN
cord-006229-7yoilsho	3631	9	glycidyl	glycidyl	NNP
cord-006229-7yoilsho	3631	10	esters	ester	NNS
cord-006229-7yoilsho	3631	11	in	in	IN
cord-006229-7yoilsho	3631	12	humans	human	NNS
cord-006229-7yoilsho	3631	13	is	be	VBZ
cord-006229-7yoilsho	3631	14	difficult	difficult	JJ
cord-006229-7yoilsho	3631	15	,	,	,
cord-006229-7yoilsho	3631	16	because	because	IN
cord-006229-7yoilsho	3631	17	the	the	DT
cord-006229-7yoilsho	3631	18	current	current	JJ
cord-006229-7yoilsho	3631	19	data	datum	NNS
cord-006229-7yoilsho	3631	20	set	set	VBN
cord-006229-7yoilsho	3631	21	for	for	IN
cord-006229-7yoilsho	3631	22	glycidyl	glycidyl	NNP
cord-006229-7yoilsho	3631	23	ester	ester	NNP
cord-006229-7yoilsho	3631	24	contents	content	NNS
cord-006229-7yoilsho	3631	25	in	in	IN
cord-006229-7yoilsho	3631	26	food	food	NN
cord-006229-7yoilsho	3631	27	is	be	VBZ
cord-006229-7yoilsho	3631	28	incomplete	incomplete	JJ
cord-006229-7yoilsho	3631	29	.	.	.
cord-006229-7yoilsho	3632	1	We	-PRON-	PRP
cord-006229-7yoilsho	3632	2	developed	develop	VBD
cord-006229-7yoilsho	3632	3	a	a	DT
cord-006229-7yoilsho	3632	4	method	method	NN
cord-006229-7yoilsho	3632	5	for	for	IN
cord-006229-7yoilsho	3632	6	the	the	DT
cord-006229-7yoilsho	3632	7	determination	determination	NN
cord-006229-7yoilsho	3632	8	of	of	IN
cord-006229-7yoilsho	3632	9	the	the	DT
cord-006229-7yoilsho	3632	10	internal	internal	JJ
cord-006229-7yoilsho	3632	11	exposure	exposure	NN
cord-006229-7yoilsho	3632	12	to	to	IN
cord-006229-7yoilsho	3632	13	glycidol	glycidol	NNP
cord-006229-7yoilsho	3632	14	by	by	IN
cord-006229-7yoilsho	3632	15	mass	mass	NNP
cord-006229-7yoilsho	3632	16	spectrometric	spectrometric	NNP
cord-006229-7yoilsho	3632	17	quantification	quantification	NN
cord-006229-7yoilsho	3632	18	of	of	IN
cord-006229-7yoilsho	3632	19	a	a	DT
cord-006229-7yoilsho	3632	20	hemoglobin	hemoglobin	NN
cord-006229-7yoilsho	3632	21	adduct	adduct	NN
cord-006229-7yoilsho	3632	22	reflecting	reflect	VBG
cord-006229-7yoilsho	3632	23	the	the	DT
cord-006229-7yoilsho	3632	24	total	total	JJ
cord-006229-7yoilsho	3632	25	glycidol	glycidol	NN
cord-006229-7yoilsho	3632	26	burden	burden	NN
cord-006229-7yoilsho	3632	27	over	over	IN
cord-006229-7yoilsho	3632	28	approximately	approximately	RB
cord-006229-7yoilsho	3632	29	three	three	CD
cord-006229-7yoilsho	3632	30	months	month	NNS
cord-006229-7yoilsho	3632	31	.	.	.
cord-006229-7yoilsho	3633	1	A	a	DT
cord-006229-7yoilsho	3633	2	modified	modify	VBN
cord-006229-7yoilsho	3633	3	Edman	Edman	NNP
cord-006229-7yoilsho	3633	4	degradation	degradation	NN
cord-006229-7yoilsho	3633	5	was	be	VBD
cord-006229-7yoilsho	3633	6	adapted	adapt	VBN
cord-006229-7yoilsho	3633	7	for	for	IN
cord-006229-7yoilsho	3633	8	the	the	DT
cord-006229-7yoilsho	3633	9	cleavage	cleavage	NN
cord-006229-7yoilsho	3633	10	of	of	IN
cord-006229-7yoilsho	3633	11	the	the	DT
cord-006229-7yoilsho	3633	12	valine	valine	NN
cord-006229-7yoilsho	3633	13	residues	residue	NNS
cord-006229-7yoilsho	3633	14	from	from	IN
cord-006229-7yoilsho	3633	15	the	the	DT
cord-006229-7yoilsho	3633	16	N	N	NNP
cord-006229-7yoilsho	3633	17	-	-	HYPH
cord-006229-7yoilsho	3633	18	termini	termini	NNP
cord-006229-7yoilsho	3633	19	of	of	IN
cord-006229-7yoilsho	3633	20	hemoglobin	hemoglobin	NN
cord-006229-7yoilsho	3633	21	by	by	IN
cord-006229-7yoilsho	3633	22	fluoresceinisothiocyanat	fluoresceinisothiocyanat	NNP
cord-006229-7yoilsho	3633	23	(	(	-LRB-
cord-006229-7yoilsho	3633	24	FITC	FITC	NNP
cord-006229-7yoilsho	3633	25	)	)	-RRB-
cord-006229-7yoilsho	3634	1	(	(	-LRB-
cord-006229-7yoilsho	3634	2	von	von	NNP
cord-006229-7yoilsho	3634	3	Stedingk	Stedingk	NNP
cord-006229-7yoilsho	3634	4	et	et	NNP
cord-006229-7yoilsho	3634	5	al	al	NNP
cord-006229-7yoilsho	3634	6	.	.	.
cord-006229-7yoilsho	3635	1	(	(	-LRB-
cord-006229-7yoilsho	3635	2	2011	2011	CD
cord-006229-7yoilsho	3635	3	)	)	-RRB-
cord-006229-7yoilsho	3636	1	Chem	Chem	NNP
cord-006229-7yoilsho	3636	2	Res	Res	NNP
cord-006229-7yoilsho	3636	3	Toxicol	Toxicol	NNP
cord-006229-7yoilsho	3636	4	24	24	CD
cord-006229-7yoilsho	3636	5	,	,	,
cord-006229-7yoilsho	3636	6	1957	1957	CD
cord-006229-7yoilsho	3636	7	resulting	result	VBG
cord-006229-7yoilsho	3636	8	in	in	IN
cord-006229-7yoilsho	3636	9	the	the	DT
cord-006229-7yoilsho	3636	10	formation	formation	NN
cord-006229-7yoilsho	3636	11	of	of	IN
cord-006229-7yoilsho	3636	12	dihydroxypropyl	dihydroxypropyl	NN
cord-006229-7yoilsho	3636	13	-	-	HYPH
cord-006229-7yoilsho	3636	14	valine	valine	NN
cord-006229-7yoilsho	3636	15	-	-	HYPH
cord-006229-7yoilsho	3636	16	fluorescein	fluorescein	NN
cord-006229-7yoilsho	3636	17	thiohydantoin	thiohydantoin	NNP
cord-006229-7yoilsho	3636	18	(	(	-LRB-
cord-006229-7yoilsho	3636	19	DHP	DHP	NNP
cord-006229-7yoilsho	3636	20	-	-	HYPH
cord-006229-7yoilsho	3636	21	Val	Val	NNP
cord-006229-7yoilsho	3636	22	-	-	HYPH
cord-006229-7yoilsho	3636	23	FTH	FTH	NNP
cord-006229-7yoilsho	3636	24	)	)	-RRB-
cord-006229-7yoilsho	3636	25	.	.	.
cord-006229-7yoilsho	3637	1	The	the	DT
cord-006229-7yoilsho	3637	2	target	target	NN
cord-006229-7yoilsho	3637	3	analyte	analyte	NN
cord-006229-7yoilsho	3637	4	is	be	VBZ
cord-006229-7yoilsho	3637	5	purified	purify	VBN
cord-006229-7yoilsho	3637	6	with	with	IN
cord-006229-7yoilsho	3637	7	mixed	mixed	JJ
cord-006229-7yoilsho	3637	8	-	-	HYPH
cord-006229-7yoilsho	3637	9	mode	mode	NN
cord-006229-7yoilsho	3637	10	anion	anion	NN
cord-006229-7yoilsho	3637	11	-	-	HYPH
cord-006229-7yoilsho	3637	12	exchange	exchange	NN
cord-006229-7yoilsho	3637	13	solid	solid	JJ
cord-006229-7yoilsho	3637	14	-	-	HYPH
cord-006229-7yoilsho	3637	15	phase	phase	NN
cord-006229-7yoilsho	3637	16	extraction	extraction	NN
cord-006229-7yoilsho	3637	17	and	and	CC
cord-006229-7yoilsho	3637	18	analyzed	analyze	VBN
cord-006229-7yoilsho	3637	19	by	by	IN
cord-006229-7yoilsho	3637	20	LC	LC	NNP
cord-006229-7yoilsho	3637	21	-	-	HYPH
cord-006229-7yoilsho	3637	22	MS	MS	NNP
cord-006229-7yoilsho	3637	23	/	/	SYM
cord-006229-7yoilsho	3637	24	MS	MS	NNP
cord-006229-7yoilsho	3637	25	.	.	.
cord-006229-7yoilsho	3638	1	A	a	DT
cord-006229-7yoilsho	3638	2	major	major	JJ
cord-006229-7yoilsho	3638	3	advantage	advantage	NN
cord-006229-7yoilsho	3638	4	of	of	IN
cord-006229-7yoilsho	3638	5	the	the	DT
cord-006229-7yoilsho	3638	6	technique	technique	NN
cord-006229-7yoilsho	3638	7	is	be	VBZ
cord-006229-7yoilsho	3638	8	the	the	DT
cord-006229-7yoilsho	3638	9	application	application	NN
cord-006229-7yoilsho	3638	10	to	to	IN
cord-006229-7yoilsho	3638	11	whole	whole	JJ
cord-006229-7yoilsho	3638	12	blood	blood	NN
cord-006229-7yoilsho	3638	13	samples	sample	NNS
cord-006229-7yoilsho	3638	14	,	,	,
cord-006229-7yoilsho	3638	15	which	which	WDT
cord-006229-7yoilsho	3638	16	renders	render	VBZ
cord-006229-7yoilsho	3638	17	the	the	DT
cord-006229-7yoilsho	3638	18	time	time	NN
cord-006229-7yoilsho	3638	19	-	-	HYPH
cord-006229-7yoilsho	3638	20	consuming	consume	VBG
cord-006229-7yoilsho	3638	21	isolation	isolation	NN
cord-006229-7yoilsho	3638	22	of	of	IN
cord-006229-7yoilsho	3638	23	erythrocytes	erythrocyte	NNS
cord-006229-7yoilsho	3638	24	unnecessary	unnecessary	JJ
cord-006229-7yoilsho	3638	25	.	.	.
cord-006229-7yoilsho	3639	1	We	-PRON-	PRP
cord-006229-7yoilsho	3639	2	synthesized	synthesize	VBD
cord-006229-7yoilsho	3639	3	DHP	DHP	NNP
cord-006229-7yoilsho	3639	4	-	-	HYPH
cord-006229-7yoilsho	3639	5	d	d	NNP
cord-006229-7yoilsho	3639	6	7	7	CD
cord-006229-7yoilsho	3639	7	-Val	-val	JJ
cord-006229-7yoilsho	3639	8	-	-	HYPH
cord-006229-7yoilsho	3639	9	FTH	fth	NN
cord-006229-7yoilsho	3639	10	as	as	IN
cord-006229-7yoilsho	3639	11	an	an	DT
cord-006229-7yoilsho	3639	12	internal	internal	JJ
cord-006229-7yoilsho	3639	13	standard	standard	NN
cord-006229-7yoilsho	3639	14	for	for	IN
cord-006229-7yoilsho	3639	15	the	the	DT
cord-006229-7yoilsho	3639	16	quantification	quantification	NN
cord-006229-7yoilsho	3639	17	of	of	IN
cord-006229-7yoilsho	3639	18	the	the	DT
cord-006229-7yoilsho	3639	19	glycidol	glycidol	NNP
cord-006229-7yoilsho	3639	20	adduct	adduct	NN
cord-006229-7yoilsho	3639	21	by	by	IN
cord-006229-7yoilsho	3639	22	LC	LC	NNP
cord-006229-7yoilsho	3639	23	-	-	HYPH
cord-006229-7yoilsho	3639	24	MS	MS	NNP
cord-006229-7yoilsho	3639	25	/	/	SYM
cord-006229-7yoilsho	3639	26	MS	MS	NNP
cord-006229-7yoilsho	3639	27	multiple	multiple	JJ
cord-006229-7yoilsho	3639	28	reaction	reaction	NN
cord-006229-7yoilsho	3639	29	monitoring	monitoring	NN
cord-006229-7yoilsho	3639	30	.	.	.
cord-006229-7yoilsho	3640	1	A	a	DT
cord-006229-7yoilsho	3640	2	limit	limit	NN
cord-006229-7yoilsho	3640	3	of	of	IN
cord-006229-7yoilsho	3640	4	detection	detection	NN
cord-006229-7yoilsho	3640	5	of	of	IN
cord-006229-7yoilsho	3640	6	5	5	CD
cord-006229-7yoilsho	3640	7	fmol	fmol	NNS
cord-006229-7yoilsho	3640	8	per	per	IN
cord-006229-7yoilsho	3640	9	injection	injection	NN
cord-006229-7yoilsho	3640	10	(	(	-LRB-
cord-006229-7yoilsho	3640	11	5	5	CD
cord-006229-7yoilsho	3640	12	pmol	pmol	JJ
cord-006229-7yoilsho	3640	13	adduct	adduct	NN
cord-006229-7yoilsho	3640	14	/	/	SYM
cord-006229-7yoilsho	3640	15	g	g	NN
cord-006229-7yoilsho	3640	16	hemoglobin	hemoglobin	NN
cord-006229-7yoilsho	3640	17	)	)	-RRB-
cord-006229-7yoilsho	3640	18	was	be	VBD
cord-006229-7yoilsho	3640	19	achieved	achieve	VBN
cord-006229-7yoilsho	3640	20	.	.	.
cord-006229-7yoilsho	3641	1	The	the	DT
cord-006229-7yoilsho	3641	2	application	application	NN
cord-006229-7yoilsho	3641	3	of	of	IN
cord-006229-7yoilsho	3641	4	this	this	DT
cord-006229-7yoilsho	3641	5	method	method	NN
cord-006229-7yoilsho	3641	6	will	will	MD
cord-006229-7yoilsho	3641	7	possibly	possibly	RB
cord-006229-7yoilsho	3641	8	allow	allow	VB
cord-006229-7yoilsho	3641	9	future	future	JJ
cord-006229-7yoilsho	3641	10	monitoring	monitoring	NN
cord-006229-7yoilsho	3641	11	of	of	IN
cord-006229-7yoilsho	3641	12	the	the	DT
cord-006229-7yoilsho	3641	13	internal	internal	JJ
cord-006229-7yoilsho	3641	14	exposure	exposure	NN
cord-006229-7yoilsho	3641	15	of	of	IN
cord-006229-7yoilsho	3641	16	glycidol	glycidol	NNP
cord-006229-7yoilsho	3641	17	in	in	IN
cord-006229-7yoilsho	3641	18	human	human	JJ
cord-006229-7yoilsho	3641	19	studies	study	NNS
cord-006229-7yoilsho	3641	20	.	.	.
cord-006229-7yoilsho	3641	21	 	 	_SP
cord-006229-7yoilsho	3642	1	Glycidol	Glycidol	NNP
cord-006229-7yoilsho	3642	2	and	and	CC
cord-006229-7yoilsho	3642	3	3-monochloropropane-1,2-diol	3-monochloropropane-1,2-diol	NNP
cord-006229-7yoilsho	3642	4	(	(	-LRB-
cord-006229-7yoilsho	3642	5	3-MCPD	3-mcpd	NN
cord-006229-7yoilsho	3642	6	)	)	-RRB-
cord-006229-7yoilsho	3642	7	are	be	VBP
cord-006229-7yoilsho	3642	8	carcinogenic	carcinogenic	JJ
cord-006229-7yoilsho	3642	9	food	food	NN
cord-006229-7yoilsho	3642	10	contaminants	contaminant	NNS
cord-006229-7yoilsho	3642	11	,	,	,
cord-006229-7yoilsho	3642	12	which	which	WDT
cord-006229-7yoilsho	3642	13	are	be	VBP
cord-006229-7yoilsho	3642	14	present	present	JJ
cord-006229-7yoilsho	3642	15	in	in	IN
cord-006229-7yoilsho	3642	16	heat	heat	NN
cord-006229-7yoilsho	3642	17	-	-	HYPH
cord-006229-7yoilsho	3642	18	processed	process	VBN
cord-006229-7yoilsho	3642	19	oils	oil	NNS
cord-006229-7yoilsho	3642	20	and	and	CC
cord-006229-7yoilsho	3642	21	fats	fat	NNS
cord-006229-7yoilsho	3642	22	mainly	mainly	RB
cord-006229-7yoilsho	3642	23	in	in	IN
cord-006229-7yoilsho	3642	24	form	form	NN
cord-006229-7yoilsho	3642	25	of	of	IN
cord-006229-7yoilsho	3642	26	fatty	fatty	JJ
cord-006229-7yoilsho	3642	27	acid	acid	NN
cord-006229-7yoilsho	3642	28	esters	ester	NNS
cord-006229-7yoilsho	3642	29	.	.	.
cord-006229-7yoilsho	3643	1	The	the	DT
cord-006229-7yoilsho	3643	2	risk	risk	NN
cord-006229-7yoilsho	3643	3	assessment	assessment	NN
cord-006229-7yoilsho	3643	4	concerning	concern	VBG
cord-006229-7yoilsho	3643	5	human	human	JJ
cord-006229-7yoilsho	3643	6	consumption	consumption	NN
cord-006229-7yoilsho	3643	7	of	of	IN
cord-006229-7yoilsho	3643	8	these	these	DT
cord-006229-7yoilsho	3643	9	substances	substance	NNS
cord-006229-7yoilsho	3643	10	is	be	VBZ
cord-006229-7yoilsho	3643	11	complicated	complicate	VBN
cord-006229-7yoilsho	3643	12	by	by	IN
cord-006229-7yoilsho	3643	13	various	various	JJ
cord-006229-7yoilsho	3643	14	reasons	reason	NNS
cord-006229-7yoilsho	3643	15	.	.	.
cord-006229-7yoilsho	3644	1	For	for	IN
cord-006229-7yoilsho	3644	2	example	example	NN
cord-006229-7yoilsho	3644	3	,	,	,
cord-006229-7yoilsho	3644	4	the	the	DT
cord-006229-7yoilsho	3644	5	data	datum	NNS
cord-006229-7yoilsho	3644	6	on	on	IN
cord-006229-7yoilsho	3644	7	the	the	DT
cord-006229-7yoilsho	3644	8	occurrence	occurrence	NN
cord-006229-7yoilsho	3644	9	in	in	IN
cord-006229-7yoilsho	3644	10	food	food	NN
cord-006229-7yoilsho	3644	11	stuffs	stuff	NNS
cord-006229-7yoilsho	3644	12	is	be	VBZ
cord-006229-7yoilsho	3644	13	incomplete	incomplete	JJ
cord-006229-7yoilsho	3644	14	.	.	.
cord-006229-7yoilsho	3645	1	Also	also	RB
cord-006229-7yoilsho	3645	2	,	,	,
cord-006229-7yoilsho	3645	3	the	the	DT
cord-006229-7yoilsho	3645	4	amounts	amount	NNS
cord-006229-7yoilsho	3645	5	of	of	IN
cord-006229-7yoilsho	3645	6	the	the	DT
cord-006229-7yoilsho	3645	7	proximate	proximate	JJ
cord-006229-7yoilsho	3645	8	carcinogens	carcinogen	NNS
cord-006229-7yoilsho	3645	9	released	release	VBN
cord-006229-7yoilsho	3645	10	from	from	IN
cord-006229-7yoilsho	3645	11	ester	ester	NN
cord-006229-7yoilsho	3645	12	hydrolysis	hydrolysis	NN
cord-006229-7yoilsho	3645	13	in	in	IN
cord-006229-7yoilsho	3645	14	the	the	DT
cord-006229-7yoilsho	3645	15	gastrointestinal	gastrointestinal	JJ
cord-006229-7yoilsho	3645	16	tract	tract	NN
cord-006229-7yoilsho	3645	17	in	in	IN
cord-006229-7yoilsho	3645	18	humans	human	NNS
cord-006229-7yoilsho	3645	19	are	be	VBP
cord-006229-7yoilsho	3645	20	not	not	RB
cord-006229-7yoilsho	3645	21	known	know	VBN
cord-006229-7yoilsho	3645	22	.	.	.
cord-006229-7yoilsho	3646	1	Monitoring	monitor	VBG
cord-006229-7yoilsho	3646	2	of	of	IN
cord-006229-7yoilsho	3646	3	the	the	DT
cord-006229-7yoilsho	3646	4	internal	internal	JJ
cord-006229-7yoilsho	3646	5	exposure	exposure	NN
cord-006229-7yoilsho	3646	6	would	would	MD
cord-006229-7yoilsho	3646	7	be	be	VB
cord-006229-7yoilsho	3646	8	an	an	DT
cord-006229-7yoilsho	3646	9	alternative	alternative	JJ
cord-006229-7yoilsho	3646	10	strategy	strategy	NN
cord-006229-7yoilsho	3646	11	to	to	TO
cord-006229-7yoilsho	3646	12	support	support	VB
cord-006229-7yoilsho	3646	13	the	the	DT
cord-006229-7yoilsho	3646	14	assessment	assessment	NN
cord-006229-7yoilsho	3646	15	of	of	IN
cord-006229-7yoilsho	3646	16	possible	possible	JJ
cord-006229-7yoilsho	3646	17	health	health	NN
cord-006229-7yoilsho	3646	18	risks	risk	NNS
cord-006229-7yoilsho	3646	19	related	relate	VBN
cord-006229-7yoilsho	3646	20	to	to	IN
cord-006229-7yoilsho	3646	21	the	the	DT
cord-006229-7yoilsho	3646	22	intake	intake	NN
cord-006229-7yoilsho	3646	23	of	of	IN
cord-006229-7yoilsho	3646	24	glycidol	glycidol	NNP
cord-006229-7yoilsho	3646	25	and	and	CC
cord-006229-7yoilsho	3646	26	3-MCPD	3-mcpd	CD
cord-006229-7yoilsho	3646	27	and	and	CC
cord-006229-7yoilsho	3646	28	their	-PRON-	PRP$
cord-006229-7yoilsho	3646	29	fatty	fatty	JJ
cord-006229-7yoilsho	3646	30	acid	acid	NN
cord-006229-7yoilsho	3646	31	esters	ester	NNS
cord-006229-7yoilsho	3646	32	.	.	.
cord-006229-7yoilsho	3647	1	For	for	IN
cord-006229-7yoilsho	3647	2	short	short	JJ
cord-006229-7yoilsho	3647	3	-	-	HYPH
cord-006229-7yoilsho	3647	4	term	term	NN
cord-006229-7yoilsho	3647	5	monitoring	monitoring	NN
cord-006229-7yoilsho	3647	6	of	of	IN
cord-006229-7yoilsho	3647	7	the	the	DT
cord-006229-7yoilsho	3647	8	internal	internal	JJ
cord-006229-7yoilsho	3647	9	exposure	exposure	NN
cord-006229-7yoilsho	3647	10	,	,	,
cord-006229-7yoilsho	3647	11	urinary	urinary	JJ
cord-006229-7yoilsho	3647	12	metabolites	metabolite	NNS
cord-006229-7yoilsho	3647	13	are	be	VBP
cord-006229-7yoilsho	3647	14	suitable	suitable	JJ
cord-006229-7yoilsho	3647	15	biomarkers	biomarker	NNS
cord-006229-7yoilsho	3647	16	.	.	.
cord-006229-7yoilsho	3648	1	We	-PRON-	PRP
cord-006229-7yoilsho	3648	2	study	study	VBP
cord-006229-7yoilsho	3648	3	the	the	DT
cord-006229-7yoilsho	3648	4	potential	potential	JJ
cord-006229-7yoilsho	3648	5	use	use	NN
cord-006229-7yoilsho	3648	6	of	of	IN
cord-006229-7yoilsho	3648	7	two	two	CD
cord-006229-7yoilsho	3648	8	different	different	JJ
cord-006229-7yoilsho	3648	9	substances	substance	NNS
cord-006229-7yoilsho	3648	10	as	as	IN
cord-006229-7yoilsho	3648	11	descriptors	descriptor	NNS
cord-006229-7yoilsho	3648	12	of	of	IN
cord-006229-7yoilsho	3648	13	the	the	DT
cord-006229-7yoilsho	3648	14	oral	oral	JJ
cord-006229-7yoilsho	3648	15	intake	intake	NN
cord-006229-7yoilsho	3648	16	of	of	IN
cord-006229-7yoilsho	3648	17	glycidol	glycidol	NNP
cord-006229-7yoilsho	3648	18	and	and	CC
cord-006229-7yoilsho	3648	19	3-MCPD	3-mcpd	CD
cord-006229-7yoilsho	3648	20	.	.	.
cord-006229-7yoilsho	3649	1	The	the	DT
cord-006229-7yoilsho	3649	2	metabolite	metabolite	JJ
cord-006229-7yoilsho	3649	3	2,3-dihydroxy	2,3-dihydroxy	CD
cord-006229-7yoilsho	3649	4	mercapturic	mercapturic	JJ
cord-006229-7yoilsho	3649	5	acid	acid	NN
cord-006229-7yoilsho	3649	6	(	(	-LRB-
cord-006229-7yoilsho	3649	7	DHPMA	DHPMA	NNP
cord-006229-7yoilsho	3649	8	)	)	-RRB-
cord-006229-7yoilsho	3649	9	is	be	VBZ
cord-006229-7yoilsho	3649	10	generated	generate	VBN
cord-006229-7yoilsho	3649	11	following	follow	VBG
cord-006229-7yoilsho	3649	12	glutathione	glutathione	NN
cord-006229-7yoilsho	3649	13	conjugation	conjugation	NN
cord-006229-7yoilsho	3649	14	of	of	IN
cord-006229-7yoilsho	3649	15	both	both	DT
cord-006229-7yoilsho	3649	16	compounds	compound	NNS
cord-006229-7yoilsho	3649	17	.	.	.
cord-006229-7yoilsho	3650	1	The	the	DT
cord-006229-7yoilsho	3650	2	second	second	JJ
cord-006229-7yoilsho	3650	3	target	target	NN
cord-006229-7yoilsho	3650	4	analyte	analyte	NN
cord-006229-7yoilsho	3650	5	is	be	VBZ
cord-006229-7yoilsho	3650	6	3-MCPD	3-mcpd	CD
cord-006229-7yoilsho	3650	7	itself	-PRON-	PRP
cord-006229-7yoilsho	3650	8	,	,	,
cord-006229-7yoilsho	3650	9	which	which	WDT
cord-006229-7yoilsho	3650	10	may	may	MD
cord-006229-7yoilsho	3650	11	also	also	RB
cord-006229-7yoilsho	3650	12	be	be	VB
cord-006229-7yoilsho	3650	13	formed	form	VBN
cord-006229-7yoilsho	3650	14	from	from	IN
cord-006229-7yoilsho	3650	15	glycidol	glycidol	NNP
cord-006229-7yoilsho	3650	16	in	in	IN
cord-006229-7yoilsho	3650	17	the	the	DT
cord-006229-7yoilsho	3650	18	reaction	reaction	NN
cord-006229-7yoilsho	3650	19	with	with	IN
cord-006229-7yoilsho	3650	20	hydrochloric	hydrochloric	JJ
cord-006229-7yoilsho	3650	21	acid	acid	NN
cord-006229-7yoilsho	3650	22	in	in	IN
cord-006229-7yoilsho	3650	23	the	the	DT
cord-006229-7yoilsho	3650	24	stomach	stomach	NN
cord-006229-7yoilsho	3650	25	.	.	.
cord-006229-7yoilsho	3651	1	A	a	DT
cord-006229-7yoilsho	3651	2	method	method	NN
cord-006229-7yoilsho	3651	3	for	for	IN
cord-006229-7yoilsho	3651	4	the	the	DT
cord-006229-7yoilsho	3651	5	quantification	quantification	NN
cord-006229-7yoilsho	3651	6	of	of	IN
cord-006229-7yoilsho	3651	7	urinary	urinary	JJ
cord-006229-7yoilsho	3651	8	3-MCPD	3-mcpd	CD
cord-006229-7yoilsho	3651	9	by	by	IN
cord-006229-7yoilsho	3651	10	GC	GC	NNP
cord-006229-7yoilsho	3651	11	-	-	HYPH
cord-006229-7yoilsho	3651	12	MS	MS	NNP
cord-006229-7yoilsho	3651	13	is	be	VBZ
cord-006229-7yoilsho	3651	14	currently	currently	RB
cord-006229-7yoilsho	3651	15	developed	develop	VBN
cord-006229-7yoilsho	3651	16	.	.	.
cord-006229-7yoilsho	3652	1	An	an	DT
cord-006229-7yoilsho	3652	2	LC	LC	NNP
cord-006229-7yoilsho	3652	3	-	-	HYPH
cord-006229-7yoilsho	3652	4	MS	MS	NNP
cord-006229-7yoilsho	3652	5	/	/	SYM
cord-006229-7yoilsho	3652	6	MS	MS	NNP
cord-006229-7yoilsho	3652	7	multiple	multiple	JJ
cord-006229-7yoilsho	3652	8	reaction	reaction	NN
cord-006229-7yoilsho	3652	9	monitoring	monitoring	NN
cord-006229-7yoilsho	3652	10	technique	technique	NN
cord-006229-7yoilsho	3652	11	was	be	VBD
cord-006229-7yoilsho	3652	12	devised	devise	VBN
cord-006229-7yoilsho	3652	13	for	for	IN
cord-006229-7yoilsho	3652	14	the	the	DT
cord-006229-7yoilsho	3652	15	quantification	quantification	NN
cord-006229-7yoilsho	3652	16	of	of	IN
cord-006229-7yoilsho	3652	17	DHPMA	DHPMA	NNP
cord-006229-7yoilsho	3652	18	in	in	IN
cord-006229-7yoilsho	3652	19	urine	urine	NN
cord-006229-7yoilsho	3652	20	samples	sample	NNS
cord-006229-7yoilsho	3652	21	with	with	IN
cord-006229-7yoilsho	3652	22	the	the	DT
cord-006229-7yoilsho	3652	23	isotope	isotope	NN
cord-006229-7yoilsho	3652	24	-	-	HYPH
cord-006229-7yoilsho	3652	25	labeled	label	VBN
cord-006229-7yoilsho	3652	26	reference	reference	NN
cord-006229-7yoilsho	3652	27	compound	compound	NN
cord-006229-7yoilsho	3652	28	13	13	CD
cord-006229-7yoilsho	3652	29	C	c	NN
cord-006229-7yoilsho	3652	30	2	2	CD
cord-006229-7yoilsho	3652	31	-DHPMA	-DHPMA	''
cord-006229-7yoilsho	3652	32	.	.	.
cord-006229-7yoilsho	3653	1	The	the	DT
cord-006229-7yoilsho	3653	2	limit	limit	NN
cord-006229-7yoilsho	3653	3	of	of	IN
cord-006229-7yoilsho	3653	4	quantification	quantification	NN
cord-006229-7yoilsho	3653	5	is	be	VBZ
cord-006229-7yoilsho	3653	6	10	10	CD
cord-006229-7yoilsho	3654	1	µg	µg	NNP
cord-006229-7yoilsho	3654	2	DHPMA	DHPMA	NNP
cord-006229-7yoilsho	3654	3	/	/	SYM
cord-006229-7yoilsho	3654	4	l	l	NN
cord-006229-7yoilsho	3654	5	.	.	.
cord-006229-7yoilsho	3655	1	Related	relate	VBN
cord-006229-7yoilsho	3655	2	to	to	IN
cord-006229-7yoilsho	3655	3	creatinine	creatinine	NN
cord-006229-7yoilsho	3655	4	,	,	,
cord-006229-7yoilsho	3655	5	the	the	DT
cord-006229-7yoilsho	3655	6	analyte	analyte	NN
cord-006229-7yoilsho	3655	7	was	be	VBD
cord-006229-7yoilsho	3655	8	detected	detect	VBN
cord-006229-7yoilsho	3655	9	to	to	TO
cord-006229-7yoilsho	3655	10	be	be	VB
cord-006229-7yoilsho	3655	11	in	in	IN
cord-006229-7yoilsho	3655	12	a	a	DT
cord-006229-7yoilsho	3655	13	relatively	relatively	RB
cord-006229-7yoilsho	3655	14	small	small	JJ
cord-006229-7yoilsho	3655	15	concentration	concentration	NN
cord-006229-7yoilsho	3655	16	range	range	NN
cord-006229-7yoilsho	3655	17	in	in	IN
cord-006229-7yoilsho	3655	18	urine	urine	NN
cord-006229-7yoilsho	3655	19	samples	sample	NNS
cord-006229-7yoilsho	3655	20	from	from	IN
cord-006229-7yoilsho	3655	21	humans	human	NNS
cord-006229-7yoilsho	3655	22	.	.	.
cord-006229-7yoilsho	3656	1	The	the	DT
cord-006229-7yoilsho	3656	2	average	average	JJ
cord-006229-7yoilsho	3656	3	concentration	concentration	NN
cord-006229-7yoilsho	3656	4	in	in	IN
cord-006229-7yoilsho	3656	5	urine	urine	NN
cord-006229-7yoilsho	3656	6	samples	sample	NNS
cord-006229-7yoilsho	3656	7	(	(	-LRB-
cord-006229-7yoilsho	3656	8	n	n	NN
cord-006229-7yoilsho	3656	9	=	=	SYM
cord-006229-7yoilsho	3656	10	45	45	CD
cord-006229-7yoilsho	3656	11	)	)	-RRB-
cord-006229-7yoilsho	3656	12	of	of	IN
cord-006229-7yoilsho	3656	13	one	one	CD
cord-006229-7yoilsho	3656	14	male	male	NN
cord-006229-7yoilsho	3656	15	volunteer	volunteer	NN
cord-006229-7yoilsho	3656	16	collected	collect	VBN
cord-006229-7yoilsho	3656	17	over	over	IN
cord-006229-7yoilsho	3656	18	ten	ten	CD
cord-006229-7yoilsho	3656	19	days	day	NNS
cord-006229-7yoilsho	3656	20	was	be	VBD
cord-006229-7yoilsho	3656	21	154	154	CD
cord-006229-7yoilsho	3656	22	±	±	CD
cord-006229-7yoilsho	3656	23	21	21	CD
cord-006229-7yoilsho	3656	24	µg	µg	IN
cord-006229-7yoilsho	3656	25	DHPMA	DHPMA	NNP
cord-006229-7yoilsho	3656	26	/	/	SYM
cord-006229-7yoilsho	3656	27	g	g	NN
cord-006229-7yoilsho	3656	28	creatinine	creatinine	NN
cord-006229-7yoilsho	3656	29	.	.	.
cord-006229-7yoilsho	3657	1	A	a	DT
cord-006229-7yoilsho	3657	2	meal	meal	NN
cord-006229-7yoilsho	3657	3	of	of	IN
cord-006229-7yoilsho	3657	4	a	a	DT
cord-006229-7yoilsho	3657	5	highly	highly	RB
cord-006229-7yoilsho	3657	6	contaminated	contaminate	VBN
cord-006229-7yoilsho	3657	7	,	,	,
cord-006229-7yoilsho	3657	8	commercially	commercially	RB
cord-006229-7yoilsho	3657	9	available	available	JJ
cord-006229-7yoilsho	3657	10	frying	fry	VBG
cord-006229-7yoilsho	3657	11	fat	fat	NN
cord-006229-7yoilsho	3657	12	(	(	-LRB-
cord-006229-7yoilsho	3657	13	containing	contain	VBG
cord-006229-7yoilsho	3657	14	1.1	1.1	CD
cord-006229-7yoilsho	3657	15	mg	mg	NN
cord-006229-7yoilsho	3657	16	of	of	IN
cord-006229-7yoilsho	3657	17	glycidol	glycidol	NNP
cord-006229-7yoilsho	3657	18	equivalents	equivalent	NNS
cord-006229-7yoilsho	3657	19	)	)	-RRB-
cord-006229-7yoilsho	3657	20	did	do	VBD
cord-006229-7yoilsho	3657	21	not	not	RB
cord-006229-7yoilsho	3657	22	lead	lead	VB
cord-006229-7yoilsho	3657	23	to	to	IN
cord-006229-7yoilsho	3657	24	a	a	DT
cord-006229-7yoilsho	3657	25	visible	visible	JJ
cord-006229-7yoilsho	3657	26	increase	increase	NN
cord-006229-7yoilsho	3657	27	of	of	IN
cord-006229-7yoilsho	3657	28	the	the	DT
cord-006229-7yoilsho	3657	29	urinary	urinary	JJ
cord-006229-7yoilsho	3657	30	concentrations	concentration	NNS
cord-006229-7yoilsho	3657	31	.	.	.
cord-006229-7yoilsho	3658	1	The	the	DT
cord-006229-7yoilsho	3658	2	considerable	considerable	JJ
cord-006229-7yoilsho	3658	3	background	background	NN
cord-006229-7yoilsho	3658	4	levels	level	NNS
cord-006229-7yoilsho	3658	5	of	of	IN
cord-006229-7yoilsho	3658	6	DHPMA	DHPMA	NNP
cord-006229-7yoilsho	3658	7	in	in	IN
cord-006229-7yoilsho	3658	8	urine	urine	NN
cord-006229-7yoilsho	3658	9	of	of	IN
cord-006229-7yoilsho	3658	10	humans	human	NNS
cord-006229-7yoilsho	3658	11	and	and	CC
cord-006229-7yoilsho	3658	12	also	also	RB
cord-006229-7yoilsho	3658	13	in	in	IN
cord-006229-7yoilsho	3658	14	urine	urine	NN
cord-006229-7yoilsho	3658	15	samples	sample	NNS
cord-006229-7yoilsho	3658	16	of	of	IN
cord-006229-7yoilsho	3658	17	other	other	JJ
cord-006229-7yoilsho	3658	18	mammals	mammal	NNS
cord-006229-7yoilsho	3658	19	support	support	VBP
cord-006229-7yoilsho	3658	20	the	the	DT
cord-006229-7yoilsho	3658	21	hypothesis	hypothesis	NN
cord-006229-7yoilsho	3658	22	that	that	IN
cord-006229-7yoilsho	3658	23	DHPMA	DHPMA	NNP
cord-006229-7yoilsho	3658	24	may	may	MD
cord-006229-7yoilsho	3658	25	be	be	VB
cord-006229-7yoilsho	3658	26	also	also	RB
cord-006229-7yoilsho	3658	27	be	be	VB
cord-006229-7yoilsho	3658	28	formed	form	VBN
cord-006229-7yoilsho	3658	29	from	from	IN
cord-006229-7yoilsho	3658	30	an	an	DT
cord-006229-7yoilsho	3658	31	endogenous	endogenous	JJ
cord-006229-7yoilsho	3658	32	C	C	NNP
cord-006229-7yoilsho	3658	33	3	3	CD
cord-006229-7yoilsho	3658	34	-metabolite	-metabolite	VBD
cord-006229-7yoilsho	3658	35	,	,	,
cord-006229-7yoilsho	3658	36	as	as	IN
cord-006229-7yoilsho	3658	37	already	already	RB
cord-006229-7yoilsho	3658	38	reported	report	VBN
cord-006229-7yoilsho	3658	39	by	by	IN
cord-006229-7yoilsho	3658	40	Eckert	Eckert	NNP
cord-006229-7yoilsho	3658	41	et	et	NNP
cord-006229-7yoilsho	3658	42	al	al	NNP
cord-006229-7yoilsho	3658	43	.	.	.
cord-006229-7yoilsho	3659	1	Furfuryl	furfuryl	NN
cord-006229-7yoilsho	3659	2	alcohol	alcohol	NN
cord-006229-7yoilsho	3659	3	is	be	VBZ
cord-006229-7yoilsho	3659	4	a	a	DT
cord-006229-7yoilsho	3659	5	common	common	JJ
cord-006229-7yoilsho	3659	6	food	food	NN
cord-006229-7yoilsho	3659	7	contaminant	contaminant	NN
cord-006229-7yoilsho	3659	8	formed	form	VBN
cord-006229-7yoilsho	3659	9	by	by	IN
cord-006229-7yoilsho	3659	10	acid	acid	NN
cord-006229-7yoilsho	3659	11	-	-	HYPH
cord-006229-7yoilsho	3659	12	and	and	CC
cord-006229-7yoilsho	3659	13	heat	heat	NN
cord-006229-7yoilsho	3659	14	-	-	HYPH
cord-006229-7yoilsho	3659	15	induced	induce	VBN
cord-006229-7yoilsho	3659	16	dehydration	dehydration	NN
cord-006229-7yoilsho	3659	17	from	from	IN
cord-006229-7yoilsho	3659	18	pentoses	pentose	NNS
cord-006229-7yoilsho	3659	19	.	.	.
cord-006229-7yoilsho	3660	1	It	-PRON-	PRP
cord-006229-7yoilsho	3660	2	induced	induce	VBD
cord-006229-7yoilsho	3660	3	renal	renal	JJ
cord-006229-7yoilsho	3660	4	tubule	tubule	NN
cord-006229-7yoilsho	3660	5	neoplasms	neoplasm	NNS
cord-006229-7yoilsho	3660	6	in	in	IN
cord-006229-7yoilsho	3660	7	male	male	JJ
cord-006229-7yoilsho	3660	8	B6C3F1	b6c3f1	JJ
cord-006229-7yoilsho	3660	9	mice	mouse	NNS
cord-006229-7yoilsho	3660	10	and	and	CC
cord-006229-7yoilsho	3660	11	nasal	nasal	JJ
cord-006229-7yoilsho	3660	12	neoplasms	neoplasm	NNS
cord-006229-7yoilsho	3660	13	in	in	IN
cord-006229-7yoilsho	3660	14	male	male	JJ
cord-006229-7yoilsho	3660	15	F344	F344	NNS
cord-006229-7yoilsho	3660	16	/	/	SYM
cord-006229-7yoilsho	3660	17	N	n	CD
cord-006229-7yoilsho	3660	18	rats	rat	NNS
cord-006229-7yoilsho	3660	19	in	in	IN
cord-006229-7yoilsho	3660	20	a	a	DT
cord-006229-7yoilsho	3660	21	study	study	NN
cord-006229-7yoilsho	3660	22	of	of	IN
cord-006229-7yoilsho	3660	23	the	the	DT
cord-006229-7yoilsho	3660	24	National	National	NNP
cord-006229-7yoilsho	3660	25	Toxicology	Toxicology	NNP
cord-006229-7yoilsho	3660	26	Program	Program	NNP
cord-006229-7yoilsho	3660	27	(	(	-LRB-
cord-006229-7yoilsho	3660	28	NTP	NTP	NNP
cord-006229-7yoilsho	3660	29	)	)	-RRB-
cord-006229-7yoilsho	3660	30	.	.	.
cord-006229-7yoilsho	3661	1	The	the	DT
cord-006229-7yoilsho	3661	2	neoplastic	neoplastic	JJ
cord-006229-7yoilsho	3661	3	effects	effect	NNS
cord-006229-7yoilsho	3661	4	may	may	MD
cord-006229-7yoilsho	3661	5	originate	originate	VB
cord-006229-7yoilsho	3661	6	from	from	IN
cord-006229-7yoilsho	3661	7	sulfotransferase	sulfotransferase	NNP
cord-006229-7yoilsho	3661	8	(	(	-LRB-
cord-006229-7yoilsho	3661	9	SULT)-catalyzed	sult)-catalyzed	JJ
cord-006229-7yoilsho	3661	10	conversion	conversion	NN
cord-006229-7yoilsho	3661	11	of	of	IN
cord-006229-7yoilsho	3661	12	furfuryl	furfuryl	NN
cord-006229-7yoilsho	3661	13	alcohol	alcohol	NN
cord-006229-7yoilsho	3661	14	into	into	IN
cord-006229-7yoilsho	3661	15	the	the	DT
cord-006229-7yoilsho	3661	16	DNA	dna	NN
cord-006229-7yoilsho	3661	17	reactive	reactive	JJ
cord-006229-7yoilsho	3661	18	and	and	CC
cord-006229-7yoilsho	3661	19	mutagenic	mutagenic	JJ
cord-006229-7yoilsho	3661	20	2-sulfoxymethylfuran	2-sulfoxymethylfuran	CD
cord-006229-7yoilsho	3661	21	.	.	.
cord-006229-7yoilsho	3662	1	The	the	DT
cord-006229-7yoilsho	3662	2	incomplete	incomplete	JJ
cord-006229-7yoilsho	3662	3	data	datum	NNS
cord-006229-7yoilsho	3662	4	set	set	NN
cord-006229-7yoilsho	3662	5	of	of	IN
cord-006229-7yoilsho	3662	6	furfuryl	furfuryl	NN
cord-006229-7yoilsho	3662	7	alcohol	alcohol	NN
cord-006229-7yoilsho	3662	8	contents	content	NNS
cord-006229-7yoilsho	3662	9	in	in	IN
cord-006229-7yoilsho	3662	10	food	food	NN
cord-006229-7yoilsho	3662	11	does	do	VBZ
cord-006229-7yoilsho	3662	12	not	not	RB
cord-006229-7yoilsho	3662	13	allow	allow	VB
cord-006229-7yoilsho	3662	14	estimating	estimate	VBG
cord-006229-7yoilsho	3662	15	the	the	DT
cord-006229-7yoilsho	3662	16	human	human	JJ
cord-006229-7yoilsho	3662	17	exposure	exposure	NN
cord-006229-7yoilsho	3662	18	.	.	.
cord-006229-7yoilsho	3663	1	Thus	thus	RB
cord-006229-7yoilsho	3663	2	,	,	,
cord-006229-7yoilsho	3663	3	we	-PRON-	PRP
cord-006229-7yoilsho	3663	4	sought	seek	VBD
cord-006229-7yoilsho	3663	5	a	a	DT
cord-006229-7yoilsho	3663	6	method	method	NN
cord-006229-7yoilsho	3663	7	for	for	IN
cord-006229-7yoilsho	3663	8	the	the	DT
cord-006229-7yoilsho	3663	9	determination	determination	NN
cord-006229-7yoilsho	3663	10	of	of	IN
cord-006229-7yoilsho	3663	11	the	the	DT
cord-006229-7yoilsho	3663	12	internal	internal	JJ
cord-006229-7yoilsho	3663	13	exposure	exposure	NN
cord-006229-7yoilsho	3663	14	.	.	.
cord-006229-7yoilsho	3664	1	Recently	recently	RB
cord-006229-7yoilsho	3664	2	,	,	,
cord-006229-7yoilsho	3664	3	the	the	DT
cord-006229-7yoilsho	3664	4	DNA	dna	NN
cord-006229-7yoilsho	3664	5	adduct	adduct	NN
cord-006229-7yoilsho	3664	6	of	of	IN
cord-006229-7yoilsho	3664	7	furfuryl	furfuryl	NN
cord-006229-7yoilsho	3664	8	alcohol	alcohol	NN
cord-006229-7yoilsho	3664	9	N	n	CD
cord-006229-7yoilsho	3664	10	2	2	CD
cord-006229-7yoilsho	3664	11	-[(furan-2-yl)methyl]-2′deoxyguanosine	-[(furan-2-yl)methyl]-2′deoxyguanosine	NN
cord-006229-7yoilsho	3664	12	was	be	VBD
cord-006229-7yoilsho	3664	13	detected	detect	VBN
cord-006229-7yoilsho	3664	14	in	in	IN
cord-006229-7yoilsho	3664	15	specimen	specimen	NN
cord-006229-7yoilsho	3664	16	of	of	IN
cord-006229-7yoilsho	3664	17	human	human	JJ
cord-006229-7yoilsho	3664	18	lung	lung	NN
cord-006229-7yoilsho	3664	19	tissue	tissue	NN
cord-006229-7yoilsho	3664	20	.	.	.
cord-006229-7yoilsho	3665	1	However	however	RB
cord-006229-7yoilsho	3665	2	,	,	,
cord-006229-7yoilsho	3665	3	human	human	JJ
cord-006229-7yoilsho	3665	4	biomonitoring	biomonitoring	NN
cord-006229-7yoilsho	3665	5	of	of	IN
cord-006229-7yoilsho	3665	6	DNA	dna	NN
cord-006229-7yoilsho	3665	7	adducts	adduct	NNS
cord-006229-7yoilsho	3665	8	has	have	VBZ
cord-006229-7yoilsho	3665	9	various	various	JJ
cord-006229-7yoilsho	3665	10	disadvantages	disadvantage	NNS
cord-006229-7yoilsho	3665	11	.	.	.
cord-006229-7yoilsho	3666	1	For	for	IN
cord-006229-7yoilsho	3666	2	example	example	NN
cord-006229-7yoilsho	3666	3	,	,	,
cord-006229-7yoilsho	3666	4	DNA	dna	NN
cord-006229-7yoilsho	3666	5	adducts	adduct	NNS
cord-006229-7yoilsho	3666	6	are	be	VBP
cord-006229-7yoilsho	3666	7	removed	remove	VBN
cord-006229-7yoilsho	3666	8	by	by	IN
cord-006229-7yoilsho	3666	9	various	various	JJ
cord-006229-7yoilsho	3666	10	repair	repair	NN
cord-006229-7yoilsho	3666	11	systems	system	NNS
cord-006229-7yoilsho	3666	12	and	and	CC
cord-006229-7yoilsho	3666	13	human	human	JJ
cord-006229-7yoilsho	3666	14	DNA	dna	NN
cord-006229-7yoilsho	3666	15	samples	sample	NNS
cord-006229-7yoilsho	3666	16	are	be	VBP
cord-006229-7yoilsho	3666	17	usually	usually	RB
cord-006229-7yoilsho	3666	18	not	not	RB
cord-006229-7yoilsho	3666	19	accessible	accessible	JJ
cord-006229-7yoilsho	3666	20	in	in	IN
cord-006229-7yoilsho	3666	21	sufficient	sufficient	JJ
cord-006229-7yoilsho	3666	22	quantities	quantity	NNS
cord-006229-7yoilsho	3666	23	.	.	.
cord-006229-7yoilsho	3667	1	We	-PRON-	PRP
cord-006229-7yoilsho	3667	2	decided	decide	VBD
cord-006229-7yoilsho	3667	3	to	to	TO
cord-006229-7yoilsho	3667	4	develop	develop	VB
cord-006229-7yoilsho	3667	5	a	a	DT
cord-006229-7yoilsho	3667	6	biomarker	biomarker	NN
cord-006229-7yoilsho	3667	7	for	for	IN
cord-006229-7yoilsho	3667	8	the	the	DT
cord-006229-7yoilsho	3667	9	internal	internal	JJ
cord-006229-7yoilsho	3667	10	exposure	exposure	NN
cord-006229-7yoilsho	3667	11	to	to	IN
cord-006229-7yoilsho	3667	12	furfuryl	furfuryl	NN
cord-006229-7yoilsho	3667	13	alcohol	alcohol	NN
cord-006229-7yoilsho	3667	14	using	use	VBG
cord-006229-7yoilsho	3667	15	blood	blood	NN
cord-006229-7yoilsho	3667	16	proteins	protein	NNS
cord-006229-7yoilsho	3667	17	as	as	IN
cord-006229-7yoilsho	3667	18	dosimetric	dosimetric	JJ
cord-006229-7yoilsho	3667	19	targets	target	NNS
cord-006229-7yoilsho	3667	20	.	.	.
cord-006229-7yoilsho	3668	1	Bladder	bladder	NN
cord-006229-7yoilsho	3668	2	cancer	cancer	NN
cord-006229-7yoilsho	3668	3	(	(	-LRB-
cord-006229-7yoilsho	3668	4	BC	BC	NNP
cord-006229-7yoilsho	3668	5	)	)	-RRB-
cord-006229-7yoilsho	3668	6	is	be	VBZ
cord-006229-7yoilsho	3668	7	a	a	DT
cord-006229-7yoilsho	3668	8	smoking	smoking	NN
cord-006229-7yoilsho	3668	9	and	and	CC
cord-006229-7yoilsho	3668	10	occupation	occupation	NN
cord-006229-7yoilsho	3668	11	related	relate	VBN
cord-006229-7yoilsho	3668	12	disease	disease	NN
cord-006229-7yoilsho	3668	13	showing	show	VBG
cord-006229-7yoilsho	3668	14	a	a	DT
cord-006229-7yoilsho	3668	15	substantial	substantial	JJ
cord-006229-7yoilsho	3668	16	genetic	genetic	JJ
cord-006229-7yoilsho	3668	17	component	component	NN
cord-006229-7yoilsho	3668	18	.	.	.
cord-006229-7yoilsho	3669	1	Though	though	IN
cord-006229-7yoilsho	3669	2	the	the	DT
cord-006229-7yoilsho	3669	3	prognosis	prognosis	NN
cord-006229-7yoilsho	3669	4	is	be	VBZ
cord-006229-7yoilsho	3669	5	generally	generally	RB
cord-006229-7yoilsho	3669	6	good	good	JJ
cord-006229-7yoilsho	3669	7	,	,	,
cord-006229-7yoilsho	3669	8	a	a	DT
cord-006229-7yoilsho	3669	9	major	major	JJ
cord-006229-7yoilsho	3669	10	problem	problem	NN
cord-006229-7yoilsho	3669	11	is	be	VBZ
cord-006229-7yoilsho	3669	12	the	the	DT
cord-006229-7yoilsho	3669	13	frequent	frequent	JJ
cord-006229-7yoilsho	3669	14	relapses	relapse	NNS
cord-006229-7yoilsho	3669	15	affecting	affect	VBG
cord-006229-7yoilsho	3669	16	about	about	IN
cord-006229-7yoilsho	3669	17	half	half	NN
cord-006229-7yoilsho	3669	18	of	of	IN
cord-006229-7yoilsho	3669	19	the	the	DT
cord-006229-7yoilsho	3669	20	patients	patient	NNS
cord-006229-7yoilsho	3669	21	.	.	.
cord-006229-7yoilsho	3670	1	N	n	CD
cord-006229-7yoilsho	3670	2	-	-	HYPH
cord-006229-7yoilsho	3670	3	acetyltransferase	acetyltransferase	NNP
cord-006229-7yoilsho	3670	4	2	2	CD
cord-006229-7yoilsho	3670	5	(	(	-LRB-
cord-006229-7yoilsho	3670	6	NAT2	NAT2	NNP
cord-006229-7yoilsho	3670	7	)	)	-RRB-
cord-006229-7yoilsho	3670	8	is	be	VBZ
cord-006229-7yoilsho	3670	9	well	well	RB
cord-006229-7yoilsho	3670	10	-	-	HYPH
cord-006229-7yoilsho	3670	11	known	know	VBN
cord-006229-7yoilsho	3670	12	to	to	TO
cord-006229-7yoilsho	3670	13	modulate	modulate	VB
cord-006229-7yoilsho	3670	14	BC	BC	NNP
cord-006229-7yoilsho	3670	15	risk	risk	NN
cord-006229-7yoilsho	3670	16	in	in	IN
cord-006229-7yoilsho	3670	17	persons	person	NNS
cord-006229-7yoilsho	3670	18	heavily	heavily	RB
cord-006229-7yoilsho	3670	19	exposed	expose	VBN
cord-006229-7yoilsho	3670	20	to	to	IN
cord-006229-7yoilsho	3670	21	carcinogenic	carcinogenic	JJ
cord-006229-7yoilsho	3670	22	aromatic	aromatic	JJ
cord-006229-7yoilsho	3670	23	amines	amine	NNS
cord-006229-7yoilsho	3670	24	.	.	.
cord-006229-7yoilsho	3671	1	We	-PRON-	PRP
cord-006229-7yoilsho	3671	2	aim	aim	VBP
cord-006229-7yoilsho	3671	3	to	to	TO
cord-006229-7yoilsho	3671	4	investigate	investigate	VB
cord-006229-7yoilsho	3671	5	the	the	DT
cord-006229-7yoilsho	3671	6	impact	impact	NN
cord-006229-7yoilsho	3671	7	of	of	IN
cord-006229-7yoilsho	3671	8	NAT2	NAT2	NNP
cord-006229-7yoilsho	3671	9	genotypes	genotype	NNS
cord-006229-7yoilsho	3671	10	,	,	,
cord-006229-7yoilsho	3671	11	in	in	IN
cord-006229-7yoilsho	3671	12	particular	particular	JJ
cord-006229-7yoilsho	3671	13	,	,	,
cord-006229-7yoilsho	3671	14	the	the	DT
cord-006229-7yoilsho	3671	15	ultraslow	ultraslow	NNP
cord-006229-7yoilsho	3671	16	genotype	genotype	NN
cord-006229-7yoilsho	3671	17	,	,	,
cord-006229-7yoilsho	3671	18	on	on	IN
cord-006229-7yoilsho	3671	19	relapse	relapse	NN
cord-006229-7yoilsho	3671	20	-	-	HYPH
cord-006229-7yoilsho	3671	21	free	free	JJ
cord-006229-7yoilsho	3671	22	time	time	NN
cord-006229-7yoilsho	3671	23	after	after	IN
cord-006229-7yoilsho	3671	24	first	first	JJ
cord-006229-7yoilsho	3671	25	diagnosis	diagnosis	NN
cord-006229-7yoilsho	3671	26	in	in	IN
cord-006229-7yoilsho	3671	27	772	772	CD
cord-006229-7yoilsho	3671	28	bladder	bladder	NN
cord-006229-7yoilsho	3671	29	cancer	cancer	NN
cord-006229-7yoilsho	3671	30	cases	case	NNS
cord-006229-7yoilsho	3671	31	.	.	.
cord-006229-7yoilsho	3672	1	We	-PRON-	PRP
cord-006229-7yoilsho	3672	2	used	use	VBD
cord-006229-7yoilsho	3672	3	follow	follow	NN
cord-006229-7yoilsho	3672	4	-	-	HYPH
cord-006229-7yoilsho	3672	5	ups	up	NNS
cord-006229-7yoilsho	3672	6	of	of	IN
cord-006229-7yoilsho	3672	7	three	three	CD
cord-006229-7yoilsho	3672	8	case	case	NN
cord-006229-7yoilsho	3672	9	-	-	HYPH
cord-006229-7yoilsho	3672	10	control	control	NN
cord-006229-7yoilsho	3672	11	studies	study	NNS
cord-006229-7yoilsho	3672	12	from	from	IN
cord-006229-7yoilsho	3672	13	Lutherstadt	Lutherstadt	NNP
cord-006229-7yoilsho	3672	14	Wittenberg	Wittenberg	NNP
cord-006229-7yoilsho	3672	15	(	(	-LRB-
cord-006229-7yoilsho	3672	16	n=207	n=207	NNP
cord-006229-7yoilsho	3672	17	)	)	-RRB-
cord-006229-7yoilsho	3672	18	,	,	,
cord-006229-7yoilsho	3672	19	Dortmund	Dortmund	NNP
cord-006229-7yoilsho	3672	20	(	(	-LRB-
cord-006229-7yoilsho	3672	21	n=167	n=167	CD
cord-006229-7yoilsho	3672	22	)	)	-RRB-
cord-006229-7yoilsho	3672	23	and	and	CC
cord-006229-7yoilsho	3672	24	Neuss	Neuss	NNP
cord-006229-7yoilsho	3672	25	(	(	-LRB-
cord-006229-7yoilsho	3672	26	n=398	n=398	CD
cord-006229-7yoilsho	3672	27	)	)	-RRB-
cord-006229-7yoilsho	3672	28	.	.	.
cord-006229-7yoilsho	3673	1	NAT2	NAT2	NNP
cord-006229-7yoilsho	3673	2	was	be	VBD
cord-006229-7yoilsho	3673	3	genotyped	genotype	VBN
cord-006229-7yoilsho	3673	4	using	use	VBG
cord-006229-7yoilsho	3673	5	seven	seven	CD
cord-006229-7yoilsho	3673	6	characteristic	characteristic	JJ
cord-006229-7yoilsho	3673	7	polymorphisms	polymorphism	NNS
cord-006229-7yoilsho	3673	8	(	(	-LRB-
cord-006229-7yoilsho	3673	9	rs1801279	rs1801279	NN
cord-006229-7yoilsho	3673	10	,	,	,
cord-006229-7yoilsho	3673	11	rs1041983	rs1041983	NNP
cord-006229-7yoilsho	3673	12	,	,	,
cord-006229-7yoilsho	3673	13	rs1801280	rs1801280	NNP
cord-006229-7yoilsho	3673	14	,	,	,
cord-006229-7yoilsho	3673	15	rs1799929	rs1799929	NNP
cord-006229-7yoilsho	3673	16	,	,	,
cord-006229-7yoilsho	3673	17	rs1799930	rs1799930	NNP
cord-006229-7yoilsho	3673	18	,	,	,
cord-006229-7yoilsho	3673	19	rs1208	rs1208	NNP
cord-006229-7yoilsho	3673	20	,	,	,
cord-006229-7yoilsho	3673	21	rs1799931	rs1799931	NNP
cord-006229-7yoilsho	3673	22	)	)	-RRB-
cord-006229-7yoilsho	3673	23	.	.	.
cord-006229-7yoilsho	3674	1	Haplotypes	haplotype	NNS
cord-006229-7yoilsho	3674	2	were	be	VBD
cord-006229-7yoilsho	3674	3	reconstructed	reconstruct	VBN
cord-006229-7yoilsho	3674	4	using	use	VBG
cord-006229-7yoilsho	3674	5	PHASE	phase	NN
cord-006229-7yoilsho	3674	6	v.2.1.1	v.2.1.1	UH
cord-006229-7yoilsho	3674	7	.	.	.
cord-006229-7yoilsho	3675	1	We	-PRON-	PRP
cord-006229-7yoilsho	3675	2	compared	compare	VBD
cord-006229-7yoilsho	3675	3	slow	slow	RB
cord-006229-7yoilsho	3675	4	to	to	IN
cord-006229-7yoilsho	3675	5	rapid	rapid	JJ
cord-006229-7yoilsho	3675	6	acetylators	acetylator	NNS
cord-006229-7yoilsho	3675	7	.	.	.
cord-006229-7yoilsho	3676	1	Additionally	additionally	RB
cord-006229-7yoilsho	3676	2	,	,	,
cord-006229-7yoilsho	3676	3	we	-PRON-	PRP
cord-006229-7yoilsho	3676	4	differentiated	differentiate	VBD
cord-006229-7yoilsho	3676	5	between	between	IN
cord-006229-7yoilsho	3676	6	the	the	DT
cord-006229-7yoilsho	3676	7	most	most	RBS
cord-006229-7yoilsho	3676	8	frequent	frequent	JJ
cord-006229-7yoilsho	3676	9	slow	slow	JJ
cord-006229-7yoilsho	3676	10	NAT2	NAT2	NNP
cord-006229-7yoilsho	3676	11	*	*	NFP
cord-006229-7yoilsho	3676	12	5B/*5B	5b/*5b	CD
cord-006229-7yoilsho	3676	13	and	and	CC
cord-006229-7yoilsho	3676	14	*	*	NFP
cord-006229-7yoilsho	3676	15	5B	5b	CD
cord-006229-7yoilsho	3676	16	/	/	SYM
cord-006229-7yoilsho	3676	17	other	other	JJ
cord-006229-7yoilsho	3676	18	slow	slow	JJ
cord-006229-7yoilsho	3676	19	haplotypes	haplotype	NNS
cord-006229-7yoilsho	3676	20	as	as	RB
cord-006229-7yoilsho	3676	21	well	well	RB
cord-006229-7yoilsho	3676	22	as	as	IN
cord-006229-7yoilsho	3676	23	between	between	IN
cord-006229-7yoilsho	3676	24	the	the	DT
cord-006229-7yoilsho	3676	25	ultra	ultra	JJ
cord-006229-7yoilsho	3676	26	-	-	JJ
cord-006229-7yoilsho	3676	27	slow	slow	JJ
cord-006229-7yoilsho	3676	28	*	*	NFP
cord-006229-7yoilsho	3676	29	6A/*6A	6a/*6a	CD
cord-006229-7yoilsho	3676	30	and	and	CC
cord-006229-7yoilsho	3676	31	*	*	NFP
cord-006229-7yoilsho	3676	32	6A	6a	CD
cord-006229-7yoilsho	3676	33	/	/	SYM
cord-006229-7yoilsho	3676	34	other	other	JJ
cord-006229-7yoilsho	3676	35	slow	slow	JJ
cord-006229-7yoilsho	3676	36	haplotypes	haplotype	NNS
cord-006229-7yoilsho	3676	37	compared	compare	VBN
cord-006229-7yoilsho	3676	38	to	to	IN
cord-006229-7yoilsho	3676	39	rapid	rapid	JJ
cord-006229-7yoilsho	3676	40	acetylators	acetylator	NNS
cord-006229-7yoilsho	3676	41	.	.	.
cord-006229-7yoilsho	3677	1	Chi	Chi	NNP
cord-006229-7yoilsho	3677	2	-	-	HYPH
cord-006229-7yoilsho	3677	3	square	square	JJ
cord-006229-7yoilsho	3677	4	tests	test	NNS
cord-006229-7yoilsho	3677	5	used	use	VBD
cord-006229-7yoilsho	3677	6	to	to	TO
cord-006229-7yoilsho	3677	7	check	check	VB
cord-006229-7yoilsho	3677	8	the	the	DT
cord-006229-7yoilsho	3677	9	frequency	frequency	NN
cord-006229-7yoilsho	3677	10	of	of	IN
cord-006229-7yoilsho	3677	11	relapses	relapse	NNS
cord-006229-7yoilsho	3677	12	in	in	IN
cord-006229-7yoilsho	3677	13	ultra	ultra	JJ
cord-006229-7yoilsho	3677	14	-	-	JJ
cord-006229-7yoilsho	3677	15	slow	slow	JJ
cord-006229-7yoilsho	3677	16	,	,	,
cord-006229-7yoilsho	3677	17	slow	slow	JJ
cord-006229-7yoilsho	3677	18	and	and	CC
cord-006229-7yoilsho	3677	19	rapid	rapid	JJ
cord-006229-7yoilsho	3677	20	acetylators	acetylator	NNS
cord-006229-7yoilsho	3677	21	.	.	.
cord-006229-7yoilsho	3678	1	Genotype	genotype	NN
cord-006229-7yoilsho	3678	2	differences	difference	NNS
cord-006229-7yoilsho	3678	3	in	in	IN
cord-006229-7yoilsho	3678	4	relapse	relapse	NN
cord-006229-7yoilsho	3678	5	-	-	HYPH
cord-006229-7yoilsho	3678	6	free	free	JJ
cord-006229-7yoilsho	3678	7	time	time	NN
cord-006229-7yoilsho	3678	8	up	up	IN
cord-006229-7yoilsho	3678	9	to	to	TO
cord-006229-7yoilsho	3678	10	5	5	CD
cord-006229-7yoilsho	3678	11	yr	yr	NN
cord-006229-7yoilsho	3678	12	after	after	IN
cord-006229-7yoilsho	3678	13	first	first	JJ
cord-006229-7yoilsho	3678	14	diagnosis	diagnosis	NN
cord-006229-7yoilsho	3678	15	of	of	IN
cord-006229-7yoilsho	3678	16	BC	BC	NNP
cord-006229-7yoilsho	3678	17	were	be	VBD
cord-006229-7yoilsho	3678	18	analysed	analyse	VBN
cord-006229-7yoilsho	3678	19	using	use	VBG
cord-006229-7yoilsho	3678	20	Cox	Cox	NNP
cord-006229-7yoilsho	3678	21	proportional	proportional	JJ
cord-006229-7yoilsho	3678	22	hazards	hazard	NNS
cord-006229-7yoilsho	3678	23	models	model	NNS
cord-006229-7yoilsho	3678	24	adjusted	adjust	VBN
cord-006229-7yoilsho	3678	25	for	for	IN
cord-006229-7yoilsho	3678	26	age	age	NN
cord-006229-7yoilsho	3678	27	,	,	,
cord-006229-7yoilsho	3678	28	gender	gender	NN
cord-006229-7yoilsho	3678	29	,	,	,
cord-006229-7yoilsho	3678	30	smoking	smoking	NN
cord-006229-7yoilsho	3678	31	habits	habit	NNS
cord-006229-7yoilsho	3678	32	,	,	,
cord-006229-7yoilsho	3678	33	invasiveness	invasiveness	NN
cord-006229-7yoilsho	3678	34	and	and	CC
cord-006229-7yoilsho	3678	35	study	study	NN
cord-006229-7yoilsho	3678	36	group	group	NN
cord-006229-7yoilsho	3678	37	.	.	.
cord-006229-7yoilsho	3679	1	A	a	DT
cord-006229-7yoilsho	3679	2	total	total	NN
cord-006229-7yoilsho	3679	3	of	of	IN
cord-006229-7yoilsho	3679	4	371	371	CD
cord-006229-7yoilsho	3679	5	(	(	-LRB-
cord-006229-7yoilsho	3679	6	49	49	CD
cord-006229-7yoilsho	3679	7	%	%	NN
cord-006229-7yoilsho	3679	8	)	)	-RRB-
cord-006229-7yoilsho	3679	9	patients	patient	NNS
cord-006229-7yoilsho	3679	10	showed	show	VBD
cord-006229-7yoilsho	3679	11	a	a	DT
cord-006229-7yoilsho	3679	12	relapse	relapse	NN
cord-006229-7yoilsho	3679	13	within	within	IN
cord-006229-7yoilsho	3679	14	the	the	DT
cord-006229-7yoilsho	3679	15	first	first	JJ
cord-006229-7yoilsho	3679	16	5	5	CD
cord-006229-7yoilsho	3679	17	yr	yr	NN
cord-006229-7yoilsho	3679	18	after	after	IN
cord-006229-7yoilsho	3679	19	BC	BC	NNP
cord-006229-7yoilsho	3679	20	diagnosis	diagnosis	NN
cord-006229-7yoilsho	3679	21	.	.	.
cord-006229-7yoilsho	3680	1	Slow	slow	JJ
cord-006229-7yoilsho	3680	2	acetylators	acetylator	NNS
cord-006229-7yoilsho	3680	3	show	show	VBP
cord-006229-7yoilsho	3680	4	a	a	DT
cord-006229-7yoilsho	3680	5	higher	high	JJR
cord-006229-7yoilsho	3680	6	frequency	frequency	NN
cord-006229-7yoilsho	3680	7	of	of	IN
cord-006229-7yoilsho	3680	8	relapses	relapse	NNS
cord-006229-7yoilsho	3680	9	than	than	IN
cord-006229-7yoilsho	3680	10	rapid	rapid	JJ
cord-006229-7yoilsho	3680	11	acetylators	acetylator	NNS
cord-006229-7yoilsho	3680	12	(	(	-LRB-
cord-006229-7yoilsho	3680	13	51	51	CD
cord-006229-7yoilsho	3680	14	%	%	NN
cord-006229-7yoilsho	3680	15	vs.	vs.	IN
cord-006229-7yoilsho	3680	16	46	46	CD
cord-006229-7yoilsho	3680	17	%	%	NN
cord-006229-7yoilsho	3680	18	,	,	,
cord-006229-7yoilsho	3680	19	P=0.154	p=0.154	NN
cord-006229-7yoilsho	3680	20	)	)	-RRB-
cord-006229-7yoilsho	3680	21	.	.	.
cord-006229-7yoilsho	3681	1	This	this	DT
cord-006229-7yoilsho	3681	2	frequency	frequency	NN
cord-006229-7yoilsho	3681	3	is	be	VBZ
cord-006229-7yoilsho	3681	4	even	even	RB
cord-006229-7yoilsho	3681	5	higher	high	JJR
cord-006229-7yoilsho	3681	6	in	in	IN
cord-006229-7yoilsho	3681	7	ultra	ultra	JJ
cord-006229-7yoilsho	3681	8	-	-	JJ
cord-006229-7yoilsho	3681	9	slow	slow	JJ
cord-006229-7yoilsho	3681	10	acetylators	acetylator	NNS
cord-006229-7yoilsho	3681	11	(	(	-LRB-
cord-006229-7yoilsho	3681	12	61	61	CD
cord-006229-7yoilsho	3681	13	%	%	NN
cord-006229-7yoilsho	3681	14	,	,	,
cord-006229-7yoilsho	3681	15	OR=1.81	or=1.81	CD
cord-006229-7yoilsho	3681	16	,	,	,
cord-006229-7yoilsho	3681	17	P=0.019	P=0.019	NNP
cord-006229-7yoilsho	3681	18	)	)	-RRB-
cord-006229-7yoilsho	3681	19	but	but	CC
cord-006229-7yoilsho	3681	20	not	not	RB
cord-006229-7yoilsho	3681	21	in	in	IN
cord-006229-7yoilsho	3681	22	slow	slow	JJ
cord-006229-7yoilsho	3681	23	*	*	NFP
cord-006229-7yoilsho	3681	24	5B/*5B	5b/*5b	CD
cord-006229-7yoilsho	3681	25	genotypes	genotype	NNS
cord-006229-7yoilsho	3681	26	(	(	-LRB-
cord-006229-7yoilsho	3681	27	49	49	CD
cord-006229-7yoilsho	3681	28	%	%	NN
cord-006229-7yoilsho	3681	29	,	,	,
cord-006229-7yoilsho	3681	30	P=0.609	P=0.609	NNP
cord-006229-7yoilsho	3681	31	)	)	-RRB-
cord-006229-7yoilsho	3681	32	.	.	.
cord-006229-7yoilsho	3682	1	Ultra	ultra	JJ
cord-006229-7yoilsho	3682	2	-	-	JJ
cord-006229-7yoilsho	3682	3	slow	slow	JJ
cord-006229-7yoilsho	3682	4	acetylators	acetylator	NNS
cord-006229-7yoilsho	3682	5	had	have	VBD
cord-006229-7yoilsho	3682	6	a	a	DT
cord-006229-7yoilsho	3682	7	significantly	significantly	RB
cord-006229-7yoilsho	3682	8	shorter	short	JJR
cord-006229-7yoilsho	3682	9	relapse	relapse	VB
cord-006229-7yoilsho	3682	10	free	free	JJ
cord-006229-7yoilsho	3682	11	time	time	NN
cord-006229-7yoilsho	3682	12	within	within	IN
cord-006229-7yoilsho	3682	13	5	5	CD
cord-006229-7yoilsho	3682	14	yr	yr	NN
cord-006229-7yoilsho	3682	15	after	after	IN
cord-006229-7yoilsho	3682	16	BC	BC	NNP
cord-006229-7yoilsho	3682	17	diagnosis	diagnosis	NN
cord-006229-7yoilsho	3682	18	than	than	IN
cord-006229-7yoilsho	3682	19	rapid	rapid	JJ
cord-006229-7yoilsho	3682	20	acetylators	acetylator	NNS
cord-006229-7yoilsho	3682	21	(	(	-LRB-
cord-006229-7yoilsho	3682	22	median	median	NN
cord-006229-7yoilsho	3682	23	0.66	0.66	CD
cord-006229-7yoilsho	3682	24	vs.	vs.	NN
cord-006229-7yoilsho	3682	25	0.94	0.94	CD
cord-006229-7yoilsho	3682	26	yr	yr	NNS
cord-006229-7yoilsho	3682	27	,	,	,
cord-006229-7yoilsho	3682	28	HR=1.57	HR=1.57	NNP
cord-006229-7yoilsho	3682	29	,	,	,
cord-006229-7yoilsho	3682	30	P=0.009	p=0.009	NN
cord-006229-7yoilsho	3682	31	)	)	-RRB-
cord-006229-7yoilsho	3682	32	.	.	.
cord-006229-7yoilsho	3683	1	This	this	DT
cord-006229-7yoilsho	3683	2	trend	trend	NN
cord-006229-7yoilsho	3683	3	was	be	VBD
cord-006229-7yoilsho	3683	4	not	not	RB
cord-006229-7yoilsho	3683	5	that	that	RB
cord-006229-7yoilsho	3683	6	pronounced	pronounce	VBN
cord-006229-7yoilsho	3683	7	in	in	IN
cord-006229-7yoilsho	3683	8	all	all	DT
cord-006229-7yoilsho	3683	9	slow	slow	JJ
cord-006229-7yoilsho	3683	10	acetylators	acetylator	NNS
cord-006229-7yoilsho	3683	11	combined	combine	VBN
cord-006229-7yoilsho	3683	12	(	(	-LRB-
cord-006229-7yoilsho	3683	13	0.78	0.78	CD
cord-006229-7yoilsho	3683	14	yr	yr	NN
cord-006229-7yoilsho	3683	15	,	,	,
cord-006229-7yoilsho	3683	16	HR=1.19	HR=1.19	NNP
cord-006229-7yoilsho	3683	17	,	,	,
cord-006229-7yoilsho	3683	18	P=0.127	P=0.127	NNP
cord-006229-7yoilsho	3683	19	)	)	-RRB-
cord-006229-7yoilsho	3683	20	nor	nor	CC
cord-006229-7yoilsho	3683	21	in	in	IN
cord-006229-7yoilsho	3683	22	the	the	DT
cord-006229-7yoilsho	3683	23	subgroup	subgroup	NN
cord-006229-7yoilsho	3683	24	of	of	IN
cord-006229-7yoilsho	3683	25	NAT2	NAT2	NNP
cord-006229-7yoilsho	3683	26	*	*	NFP
cord-006229-7yoilsho	3683	27	5B/*5B	5b/*5b	CD
cord-006229-7yoilsho	3683	28	genotypes	genotype	NNS
cord-006229-7yoilsho	3683	29	(	(	-LRB-
cord-006229-7yoilsho	3683	30	0.79	0.79	CD
cord-006229-7yoilsho	3683	31	yr	yr	NN
cord-006229-7yoilsho	3683	32	,	,	,
cord-006229-7yoilsho	3683	33	HR=1.20	HR=1.20	NNP
cord-006229-7yoilsho	3683	34	,	,	,
cord-006229-7yoilsho	3683	35	P=0.255	P=0.255	NNP
cord-006229-7yoilsho	3683	36	)	)	-RRB-
cord-006229-7yoilsho	3683	37	.	.	.
cord-006229-7yoilsho	3684	1	The	the	DT
cord-006229-7yoilsho	3684	2	effect	effect	NN
cord-006229-7yoilsho	3684	3	of	of	IN
cord-006229-7yoilsho	3684	4	ultraslow	ultraslow	JJ
cord-006229-7yoilsho	3684	5	NAT2	NAT2	NNP
cord-006229-7yoilsho	3684	6	is	be	VBZ
cord-006229-7yoilsho	3684	7	even	even	RB
cord-006229-7yoilsho	3684	8	more	more	RBR
cord-006229-7yoilsho	3684	9	pronounced	pronounced	JJ
cord-006229-7yoilsho	3684	10	in	in	IN
cord-006229-7yoilsho	3684	11	smokers	smoker	NNS
cord-006229-7yoilsho	3684	12	(	(	-LRB-
cord-006229-7yoilsho	3684	13	HR=1.78	hr=1.78	XX
cord-006229-7yoilsho	3684	14	,	,	,
cord-006229-7yoilsho	3684	15	P=0.003	P=0.003	NNP
cord-006229-7yoilsho	3684	16	)	)	-RRB-
cord-006229-7yoilsho	3684	17	but	but	CC
cord-006229-7yoilsho	3684	18	absent	absent	JJ
cord-006229-7yoilsho	3684	19	nonsmokers	nonsmoker	NNS
cord-006229-7yoilsho	3684	20	(	(	-LRB-
cord-006229-7yoilsho	3684	21	HR=0.89	hr=0.89	RB
cord-006229-7yoilsho	3684	22	,	,	,
cord-006229-7yoilsho	3684	23	P=0.781	P=0.781	NNP
cord-006229-7yoilsho	3684	24	)	)	-RRB-
cord-006229-7yoilsho	3684	25	.	.	.
cord-006229-7yoilsho	3685	1	Ultra	ultra	JJ
cord-006229-7yoilsho	3685	2	-	-	JJ
cord-006229-7yoilsho	3685	3	slow	slow	JJ
cord-006229-7yoilsho	3685	4	NAT2	NAT2	NNP
cord-006229-7yoilsho	3685	5	seems	seem	VBZ
cord-006229-7yoilsho	3685	6	to	to	TO
cord-006229-7yoilsho	3685	7	be	be	VB
cord-006229-7yoilsho	3685	8	associated	associate	VBN
cord-006229-7yoilsho	3685	9	with	with	IN
cord-006229-7yoilsho	3685	10	a	a	DT
cord-006229-7yoilsho	3685	11	higher	high	JJR
cord-006229-7yoilsho	3685	12	recurrence	recurrence	NN
cord-006229-7yoilsho	3685	13	risk	risk	NN
cord-006229-7yoilsho	3685	14	and	and	CC
cord-006229-7yoilsho	3685	15	a	a	DT
cord-006229-7yoilsho	3685	16	shorter	short	JJR
cord-006229-7yoilsho	3685	17	relapse	relapse	NN
cord-006229-7yoilsho	3685	18	-	-	HYPH
cord-006229-7yoilsho	3685	19	free	free	JJ
cord-006229-7yoilsho	3685	20	time	time	NN
cord-006229-7yoilsho	3685	21	,	,	,
cord-006229-7yoilsho	3685	22	especially	especially	RB
cord-006229-7yoilsho	3685	23	in	in	IN
cord-006229-7yoilsho	3685	24	smokers	smoker	NNS
cord-006229-7yoilsho	3685	25	.	.	.
cord-006229-7yoilsho	3686	1	Slow	Slow	NNP
cord-006229-7yoilsho	3686	2	NAT2	NAT2	NNP
cord-006229-7yoilsho	3686	3	in	in	IN
cord-006229-7yoilsho	3686	4	general	general	JJ
cord-006229-7yoilsho	3686	5	seems	seem	VBZ
cord-006229-7yoilsho	3686	6	to	to	TO
cord-006229-7yoilsho	3686	7	have	have	VB
cord-006229-7yoilsho	3686	8	less	less	JJR
cord-006229-7yoilsho	3686	9	impact	impact	NN
cord-006229-7yoilsho	3686	10	on	on	IN
cord-006229-7yoilsho	3686	11	recurrence	recurrence	NN
cord-006229-7yoilsho	3686	12	.	.	.
cord-006229-7yoilsho	3687	1	Aalborg	Aalborg	NNP
cord-006229-7yoilsho	3687	2	University	University	NNP
cord-006229-7yoilsho	3687	3	,	,	,
cord-006229-7yoilsho	3687	4	Department	Department	NNP
cord-006229-7yoilsho	3687	5	of	of	IN
cord-006229-7yoilsho	3687	6	Biotechnology	Biotechnology	NNP
cord-006229-7yoilsho	3687	7	,	,	,
cord-006229-7yoilsho	3687	8	Chemistry	Chemistry	NNP
cord-006229-7yoilsho	3687	9	and	and	CC
cord-006229-7yoilsho	3687	10	Environmental	Environmental	NNP
cord-006229-7yoilsho	3687	11	Engineering	Engineering	NNP
cord-006229-7yoilsho	3687	12	,	,	,
cord-006229-7yoilsho	3687	13	Aalborg	Aalborg	NNP
cord-006229-7yoilsho	3687	14	,	,	,
cord-006229-7yoilsho	3687	15	Denmark	Denmark	NNP
cord-006229-7yoilsho	3687	16	Xenoestrogens	Xenoestrogens	NNP
cord-006229-7yoilsho	3687	17	with	with	IN
cord-006229-7yoilsho	3687	18	the	the	DT
cord-006229-7yoilsho	3687	19	potential	potential	NN
cord-006229-7yoilsho	3687	20	for	for	IN
cord-006229-7yoilsho	3687	21	endocrine	endocrine	JJ
cord-006229-7yoilsho	3687	22	disruption	disruption	NN
cord-006229-7yoilsho	3687	23	like	like	IN
cord-006229-7yoilsho	3687	24	bisphenol	bisphenol	NN
cord-006229-7yoilsho	3687	25	A	A	NNP
cord-006229-7yoilsho	3687	26	(	(	-LRB-
cord-006229-7yoilsho	3687	27	BPA	BPA	NNP
cord-006229-7yoilsho	3687	28	)	)	-RRB-
cord-006229-7yoilsho	3687	29	may	may	MD
cord-006229-7yoilsho	3687	30	bind	bind	VB
cord-006229-7yoilsho	3687	31	to	to	IN
cord-006229-7yoilsho	3687	32	the	the	DT
cord-006229-7yoilsho	3687	33	estrogen	estrogen	NN
cord-006229-7yoilsho	3687	34	receptors	receptor	NNS
cord-006229-7yoilsho	3687	35	(	(	-LRB-
cord-006229-7yoilsho	3687	36	ERs	er	NNS
cord-006229-7yoilsho	3687	37	)	)	-RRB-
cord-006229-7yoilsho	3687	38	and	and	CC
cord-006229-7yoilsho	3687	39	modulate	modulate	VB
cord-006229-7yoilsho	3687	40	expression	expression	NN
cord-006229-7yoilsho	3687	41	of	of	IN
cord-006229-7yoilsho	3687	42	ER	ER	NNP
cord-006229-7yoilsho	3687	43	target	target	NN
cord-006229-7yoilsho	3687	44	genes	gene	NNS
cord-006229-7yoilsho	3687	45	mimicking	mimic	VBG
cord-006229-7yoilsho	3687	46	the	the	DT
cord-006229-7yoilsho	3687	47	natural	natural	JJ
cord-006229-7yoilsho	3687	48	ligand	ligand	NN
cord-006229-7yoilsho	3687	49	17β	17β	NNS
cord-006229-7yoilsho	3687	50	-	-	:
cord-006229-7yoilsho	3687	51	estradiol	estradiol	NN
cord-006229-7yoilsho	3687	52	(	(	-LRB-
cord-006229-7yoilsho	3687	53	E2	E2	NNP
cord-006229-7yoilsho	3687	54	)	)	-RRB-
cord-006229-7yoilsho	3687	55	.	.	.
cord-006229-7yoilsho	3688	1	The	the	DT
cord-006229-7yoilsho	3688	2	potential	potential	NN
cord-006229-7yoilsho	3688	3	for	for	IN
cord-006229-7yoilsho	3688	4	endocrine	endocrine	JJ
cord-006229-7yoilsho	3688	5	adversity	adversity	NN
cord-006229-7yoilsho	3688	6	is	be	VBZ
cord-006229-7yoilsho	3688	7	still	still	RB
cord-006229-7yoilsho	3688	8	predominantly	predominantly	RB
cord-006229-7yoilsho	3688	9	assessed	assess	VBN
cord-006229-7yoilsho	3688	10	in	in	IN
cord-006229-7yoilsho	3688	11	vivo	vivo	NN
cord-006229-7yoilsho	3688	12	as	as	IN
cord-006229-7yoilsho	3688	13	existing	exist	VBG
cord-006229-7yoilsho	3688	14	in	in	IN
cord-006229-7yoilsho	3688	15	vitro	vitro	FW
cord-006229-7yoilsho	3688	16	tests	test	NNS
cord-006229-7yoilsho	3688	17	have	have	VBP
cord-006229-7yoilsho	3688	18	only	only	RB
cord-006229-7yoilsho	3688	19	limited	limited	JJ
cord-006229-7yoilsho	3688	20	value	value	NN
cord-006229-7yoilsho	3688	21	for	for	IN
cord-006229-7yoilsho	3688	22	an	an	DT
cord-006229-7yoilsho	3688	23	exposure	exposure	NN
cord-006229-7yoilsho	3688	24	-	-	HYPH
cord-006229-7yoilsho	3688	25	based	base	VBN
cord-006229-7yoilsho	3688	26	risk	risk	NN
cord-006229-7yoilsho	3688	27	assessment	assessment	NN
cord-006229-7yoilsho	3688	28	.	.	.
cord-006229-7yoilsho	3689	1	Thus	thus	RB
cord-006229-7yoilsho	3689	2	,	,	,
cord-006229-7yoilsho	3689	3	the	the	DT
cord-006229-7yoilsho	3689	4	development	development	NN
cord-006229-7yoilsho	3689	5	of	of	IN
cord-006229-7yoilsho	3689	6	reliable	reliable	JJ
cord-006229-7yoilsho	3689	7	bioassays	bioassay	NNS
cord-006229-7yoilsho	3689	8	for	for	IN
cord-006229-7yoilsho	3689	9	the	the	DT
cord-006229-7yoilsho	3689	10	detection	detection	NN
cord-006229-7yoilsho	3689	11	of	of	IN
cord-006229-7yoilsho	3689	12	endocrine	endocrine	JJ
cord-006229-7yoilsho	3689	13	disruptors	disruptor	NNS
cord-006229-7yoilsho	3689	14	is	be	VBZ
cord-006229-7yoilsho	3689	15	one	one	CD
cord-006229-7yoilsho	3689	16	of	of	IN
cord-006229-7yoilsho	3689	17	the	the	DT
cord-006229-7yoilsho	3689	18	paramount	paramount	JJ
cord-006229-7yoilsho	3689	19	challenges	challenge	NNS
cord-006229-7yoilsho	3689	20	faced	face	VBN
cord-006229-7yoilsho	3689	21	by	by	IN
cord-006229-7yoilsho	3689	22	modern	modern	JJ
cord-006229-7yoilsho	3689	23	toxicology	toxicology	NN
cord-006229-7yoilsho	3689	24	.	.	.
cord-006229-7yoilsho	3690	1	A	a	DT
cord-006229-7yoilsho	3690	2	targeted	target	VBN
cord-006229-7yoilsho	3690	3	metabolomics	metabolomic	NNS
cord-006229-7yoilsho	3690	4	approach	approach	NN
cord-006229-7yoilsho	3690	5	in	in	IN
cord-006229-7yoilsho	3690	6	MCF-7	MCF-7	NNP
cord-006229-7yoilsho	3690	7	cells	cell	NNS
cord-006229-7yoilsho	3690	8	treated	treat	VBN
cord-006229-7yoilsho	3690	9	with	with	IN
cord-006229-7yoilsho	3690	10	E2	E2	NNP
cord-006229-7yoilsho	3690	11	or	or	CC
cord-006229-7yoilsho	3690	12	BPA	BPA	NNP
cord-006229-7yoilsho	3690	13	revealed	reveal	VBD
cord-006229-7yoilsho	3690	14	potential	potential	JJ
cord-006229-7yoilsho	3690	15	biomarkers	biomarker	NNS
cord-006229-7yoilsho	3690	16	for	for	IN
cord-006229-7yoilsho	3690	17	the	the	DT
cord-006229-7yoilsho	3690	18	estrogenic	estrogenic	JJ
cord-006229-7yoilsho	3690	19	potency	potency	NN
cord-006229-7yoilsho	3690	20	of	of	IN
cord-006229-7yoilsho	3690	21	the	the	DT
cord-006229-7yoilsho	3690	22	studied	study	VBN
cord-006229-7yoilsho	3690	23	compounds	compound	NNS
cord-006229-7yoilsho	3690	24	.	.	.
cord-006229-7yoilsho	3691	1	Among	among	IN
cord-006229-7yoilsho	3691	2	them	-PRON-	PRP
cord-006229-7yoilsho	3691	3	were	be	VBD
cord-006229-7yoilsho	3691	4	several	several	JJ
cord-006229-7yoilsho	3691	5	phosphatidylcholines	phosphatidylcholine	NNS
cord-006229-7yoilsho	3691	6	and	and	CC
cord-006229-7yoilsho	3691	7	amino	amino	JJ
cord-006229-7yoilsho	3691	8	acids	acid	NNS
cord-006229-7yoilsho	3691	9	.	.	.
cord-006229-7yoilsho	3692	1	We	-PRON-	PRP
cord-006229-7yoilsho	3692	2	further	further	RB
cord-006229-7yoilsho	3692	3	addressed	address	VBD
cord-006229-7yoilsho	3692	4	proline	proline	NN
cord-006229-7yoilsho	3692	5	levels	level	NNS
cord-006229-7yoilsho	3692	6	that	that	WDT
cord-006229-7yoilsho	3692	7	were	be	VBD
cord-006229-7yoilsho	3692	8	found	find	VBN
cord-006229-7yoilsho	3692	9	to	to	TO
cord-006229-7yoilsho	3692	10	be	be	VB
cord-006229-7yoilsho	3692	11	strongly	strongly	RB
cord-006229-7yoilsho	3692	12	increased	increase	VBN
cord-006229-7yoilsho	3692	13	.	.	.
cord-006229-7yoilsho	3693	1	Investigations	investigation	NNS
cord-006229-7yoilsho	3693	2	of	of	IN
cord-006229-7yoilsho	3693	3	proline	proline	NN
cord-006229-7yoilsho	3693	4	levels	level	NNS
cord-006229-7yoilsho	3693	5	over	over	IN
cord-006229-7yoilsho	3693	6	time	time	NN
cord-006229-7yoilsho	3693	7	showed	show	VBD
cord-006229-7yoilsho	3693	8	a	a	DT
cord-006229-7yoilsho	3693	9	clear	clear	JJ
cord-006229-7yoilsho	3693	10	proliferation	proliferation	NN
cord-006229-7yoilsho	3693	11	correlated	correlate	VBN
cord-006229-7yoilsho	3693	12	concentration	concentration	NN
cord-006229-7yoilsho	3693	13	dependency	dependency	NN
cord-006229-7yoilsho	3693	14	after	after	IN
cord-006229-7yoilsho	3693	15	both	both	CC
cord-006229-7yoilsho	3693	16	E2	E2	NNP
cord-006229-7yoilsho	3693	17	and	and	CC
cord-006229-7yoilsho	3693	18	BPA	BPA	NNP
cord-006229-7yoilsho	3693	19	stimulation	stimulation	NN
cord-006229-7yoilsho	3693	20	.	.	.
cord-006229-7yoilsho	3694	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	3694	2	,	,	,
cord-006229-7yoilsho	3694	3	siRNA	siRNA	NNP
cord-006229-7yoilsho	3694	4	knockdown	knockdown	NN
cord-006229-7yoilsho	3694	5	experiments	experiment	NNS
cord-006229-7yoilsho	3694	6	suggested	suggest	VBD
cord-006229-7yoilsho	3694	7	an	an	DT
cord-006229-7yoilsho	3694	8	influence	influence	NN
cord-006229-7yoilsho	3694	9	of	of	IN
cord-006229-7yoilsho	3694	10	the	the	DT
cord-006229-7yoilsho	3694	11	oncogenic	oncogenic	JJ
cord-006229-7yoilsho	3694	12	transcription	transcription	NN
cord-006229-7yoilsho	3694	13	factor	factor	NN
cord-006229-7yoilsho	3694	14	MYC	MYC	NNP
cord-006229-7yoilsho	3694	15	and	and	CC
cord-006229-7yoilsho	3694	16	the	the	DT
cord-006229-7yoilsho	3694	17	dependency	dependency	NN
cord-006229-7yoilsho	3694	18	of	of	IN
cord-006229-7yoilsho	3694	19	ERα	ERα	NNS
cord-006229-7yoilsho	3694	20	activation	activation	NN
cord-006229-7yoilsho	3694	21	on	on	IN
cord-006229-7yoilsho	3694	22	the	the	DT
cord-006229-7yoilsho	3694	23	estrogen	estrogen	NN
cord-006229-7yoilsho	3694	24	-	-	HYPH
cord-006229-7yoilsho	3694	25	mediated	mediate	VBN
cord-006229-7yoilsho	3694	26	proline	proline	NN
cord-006229-7yoilsho	3694	27	increase	increase	NN
cord-006229-7yoilsho	3694	28	.	.	.
cord-006229-7yoilsho	3695	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	3695	2	study	study	NN
cord-006229-7yoilsho	3695	3	demonstrates	demonstrate	VBZ
cord-006229-7yoilsho	3695	4	metabolomics	metabolomic	NNS
cord-006229-7yoilsho	3695	5	as	as	IN
cord-006229-7yoilsho	3695	6	a	a	DT
cord-006229-7yoilsho	3695	7	powerful	powerful	JJ
cord-006229-7yoilsho	3695	8	tool	tool	NN
cord-006229-7yoilsho	3695	9	for	for	IN
cord-006229-7yoilsho	3695	10	biomarker	biomarker	NN
cord-006229-7yoilsho	3695	11	identification	identification	NN
cord-006229-7yoilsho	3695	12	and	and	CC
cord-006229-7yoilsho	3695	13	hypothesis	hypothesis	NN
cord-006229-7yoilsho	3695	14	generation	generation	NN
cord-006229-7yoilsho	3695	15	.	.	.
cord-006229-7yoilsho	3696	1	The	the	DT
cord-006229-7yoilsho	3696	2	results	result	NNS
cord-006229-7yoilsho	3696	3	could	could	MD
cord-006229-7yoilsho	3696	4	be	be	VB
cord-006229-7yoilsho	3696	5	used	use	VBN
cord-006229-7yoilsho	3696	6	further	far	RBR
cord-006229-7yoilsho	3696	7	to	to	TO
cord-006229-7yoilsho	3696	8	develop	develop	VB
cord-006229-7yoilsho	3696	9	bioassays	bioassays	NNP
cord-006229-7yoilsho	3696	10	for	for	IN
cord-006229-7yoilsho	3696	11	the	the	DT
cord-006229-7yoilsho	3696	12	detection	detection	NN
cord-006229-7yoilsho	3696	13	of	of	IN
cord-006229-7yoilsho	3696	14	endocrine	endocrine	JJ
cord-006229-7yoilsho	3696	15	disruptive	disruptive	JJ
cord-006229-7yoilsho	3696	16	chemicals	chemical	NNS
cord-006229-7yoilsho	3696	17	.	.	.
cord-006229-7yoilsho	3697	1	Children	child	NNS
cord-006229-7yoilsho	3697	2	are	be	VBP
cord-006229-7yoilsho	3697	3	considered	consider	VBN
cord-006229-7yoilsho	3697	4	to	to	TO
cord-006229-7yoilsho	3697	5	be	be	VB
cord-006229-7yoilsho	3697	6	more	more	RBR
cord-006229-7yoilsho	3697	7	sensitive	sensitive	JJ
cord-006229-7yoilsho	3697	8	to	to	IN
cord-006229-7yoilsho	3697	9	most	most	JJS
cord-006229-7yoilsho	3697	10	chemicals	chemical	NNS
cord-006229-7yoilsho	3697	11	than	than	IN
cord-006229-7yoilsho	3697	12	the	the	DT
cord-006229-7yoilsho	3697	13	general	general	JJ
cord-006229-7yoilsho	3697	14	population	population	NN
cord-006229-7yoilsho	3697	15	due	due	IN
cord-006229-7yoilsho	3697	16	to	to	IN
cord-006229-7yoilsho	3697	17	a	a	DT
cord-006229-7yoilsho	3697	18	variety	variety	NN
cord-006229-7yoilsho	3697	19	of	of	IN
cord-006229-7yoilsho	3697	20	factors	factor	NNS
cord-006229-7yoilsho	3697	21	,	,	,
cord-006229-7yoilsho	3697	22	including	include	VBG
cord-006229-7yoilsho	3697	23	dynamic	dynamic	JJ
cord-006229-7yoilsho	3697	24	growth	growth	NN
cord-006229-7yoilsho	3697	25	and	and	CC
cord-006229-7yoilsho	3697	26	developmental	developmental	JJ
cord-006229-7yoilsho	3697	27	processes	process	NNS
cord-006229-7yoilsho	3697	28	as	as	RB
cord-006229-7yoilsho	3697	29	well	well	RB
cord-006229-7yoilsho	3697	30	as	as	IN
cord-006229-7yoilsho	3697	31	physiological	physiological	JJ
cord-006229-7yoilsho	3697	32	,	,	,
cord-006229-7yoilsho	3697	33	metabolic	metabolic	JJ
cord-006229-7yoilsho	3697	34	and	and	CC
cord-006229-7yoilsho	3697	35	behavioral	behavioral	JJ
cord-006229-7yoilsho	3697	36	differences	difference	NNS
cord-006229-7yoilsho	3697	37	[	[	-LRB-
cord-006229-7yoilsho	3697	38	1	1	CD
cord-006229-7yoilsho	3697	39	]	]	-RRB-
cord-006229-7yoilsho	3697	40	.	.	.
cord-006229-7yoilsho	3698	1	However	however	RB
cord-006229-7yoilsho	3698	2	,	,	,
cord-006229-7yoilsho	3698	3	only	only	RB
cord-006229-7yoilsho	3698	4	a	a	DT
cord-006229-7yoilsho	3698	5	few	few	JJ
cord-006229-7yoilsho	3698	6	data	datum	NNS
cord-006229-7yoilsho	3698	7	are	be	VBP
cord-006229-7yoilsho	3698	8	available	available	JJ
cord-006229-7yoilsho	3698	9	on	on	IN
cord-006229-7yoilsho	3698	10	the	the	DT
cord-006229-7yoilsho	3698	11	magnitude	magnitude	NN
cord-006229-7yoilsho	3698	12	of	of	IN
cord-006229-7yoilsho	3698	13	preschool	preschool	NN
cord-006229-7yoilsho	3698	14	children	child	NNS
cord-006229-7yoilsho	3698	15	's	's	POS
cord-006229-7yoilsho	3698	16	exposure	exposure	NN
cord-006229-7yoilsho	3698	17	to	to	IN
cord-006229-7yoilsho	3698	18	most	most	JJS
cord-006229-7yoilsho	3698	19	chemicals	chemical	NNS
cord-006229-7yoilsho	3698	20	present	present	JJ
cord-006229-7yoilsho	3698	21	in	in	IN
cord-006229-7yoilsho	3698	22	many	many	JJ
cord-006229-7yoilsho	3698	23	consumer	consumer	NN
cord-006229-7yoilsho	3698	24	products	product	NNS
cord-006229-7yoilsho	3698	25	.	.	.
cord-006229-7yoilsho	3699	1	Several	several	JJ
cord-006229-7yoilsho	3699	2	of	of	IN
cord-006229-7yoilsho	3699	3	these	these	DT
cord-006229-7yoilsho	3699	4	chemicals	chemical	NNS
cord-006229-7yoilsho	3699	5	are	be	VBP
cord-006229-7yoilsho	3699	6	linked	link	VBN
cord-006229-7yoilsho	3699	7	to	to	IN
cord-006229-7yoilsho	3699	8	endocrine	endocrine	JJ
cord-006229-7yoilsho	3699	9	disrupting	disrupt	VBG
cord-006229-7yoilsho	3699	10	effects	effect	NNS
cord-006229-7yoilsho	3699	11	in	in	IN
cord-006229-7yoilsho	3699	12	animal	animal	NN
cord-006229-7yoilsho	3699	13	studies	study	NNS
cord-006229-7yoilsho	3699	14	and	and	CC
cord-006229-7yoilsho	3699	15	are	be	VBP
cord-006229-7yoilsho	3699	16	suspected	suspect	VBN
cord-006229-7yoilsho	3699	17	to	to	TO
cord-006229-7yoilsho	3699	18	have	have	VB
cord-006229-7yoilsho	3699	19	also	also	RB
cord-006229-7yoilsho	3699	20	adverse	adverse	JJ
cord-006229-7yoilsho	3699	21	effects	effect	NNS
cord-006229-7yoilsho	3699	22	e.g.	e.g.	RB
cord-006229-7yoilsho	3699	23	on	on	IN
cord-006229-7yoilsho	3699	24	development	development	NN
cord-006229-7yoilsho	3699	25	and	and	CC
cord-006229-7yoilsho	3699	26	function	function	NN
cord-006229-7yoilsho	3699	27	of	of	IN
cord-006229-7yoilsho	3699	28	the	the	DT
cord-006229-7yoilsho	3699	29	reproductive	reproductive	JJ
cord-006229-7yoilsho	3699	30	organs	organ	NNS
cord-006229-7yoilsho	3699	31	as	as	RB
cord-006229-7yoilsho	3699	32	well	well	RB
cord-006229-7yoilsho	3699	33	as	as	IN
cord-006229-7yoilsho	3699	34	on	on	IN
cord-006229-7yoilsho	3699	35	neurological	neurological	JJ
cord-006229-7yoilsho	3699	36	and	and	CC
cord-006229-7yoilsho	3699	37	behavioral	behavioral	JJ
cord-006229-7yoilsho	3699	38	development	development	NN
cord-006229-7yoilsho	3699	39	in	in	IN
cord-006229-7yoilsho	3699	40	humans	human	NNS
cord-006229-7yoilsho	3699	41	.	.	.
cord-006229-7yoilsho	3700	1	Among	among	IN
cord-006229-7yoilsho	3700	2	of	of	IN
cord-006229-7yoilsho	3700	3	the	the	DT
cord-006229-7yoilsho	3700	4	chemicals	chemical	NNS
cord-006229-7yoilsho	3700	5	that	that	WDT
cord-006229-7yoilsho	3700	6	have	have	VBP
cord-006229-7yoilsho	3700	7	been	be	VBN
cord-006229-7yoilsho	3700	8	a	a	DT
cord-006229-7yoilsho	3700	9	major	major	JJ
cord-006229-7yoilsho	3700	10	focus	focus	NN
cord-006229-7yoilsho	3700	11	of	of	IN
cord-006229-7yoilsho	3700	12	discussion	discussion	NN
cord-006229-7yoilsho	3700	13	in	in	IN
cord-006229-7yoilsho	3700	14	the	the	DT
cord-006229-7yoilsho	3700	15	last	last	JJ
cord-006229-7yoilsho	3700	16	years	year	NNS
cord-006229-7yoilsho	3700	17	are	be	VBP
cord-006229-7yoilsho	3700	18	Phthalates	phthalate	NNS
cord-006229-7yoilsho	3700	19	,	,	,
cord-006229-7yoilsho	3700	20	DINCH	DINCH	NNP
cord-006229-7yoilsho	3700	21	,	,	,
cord-006229-7yoilsho	3700	22	Parabens	Parabens	NNPS
cord-006229-7yoilsho	3700	23	,	,	,
cord-006229-7yoilsho	3700	24	Bisphenol	Bisphenol	NNP
cord-006229-7yoilsho	3700	25	A	A	NNP
cord-006229-7yoilsho	3700	26	,	,	,
cord-006229-7yoilsho	3700	27	and	and	CC
cord-006229-7yoilsho	3700	28	Triclosan	Triclosan	NNP
cord-006229-7yoilsho	3700	29	due	due	IN
cord-006229-7yoilsho	3700	30	to	to	IN
cord-006229-7yoilsho	3700	31	their	-PRON-	PRP$
cord-006229-7yoilsho	3700	32	suspected	suspect	VBN
cord-006229-7yoilsho	3700	33	health	health	NN
cord-006229-7yoilsho	3700	34	effects	effect	NNS
cord-006229-7yoilsho	3700	35	.	.	.
cord-006229-7yoilsho	3701	1	Therefore	therefore	RB
cord-006229-7yoilsho	3701	2	we	-PRON-	PRP
cord-006229-7yoilsho	3701	3	aimed	aim	VBD
cord-006229-7yoilsho	3701	4	to	to	TO
cord-006229-7yoilsho	3701	5	investigate	investigate	VB
cord-006229-7yoilsho	3701	6	exposure	exposure	NN
cord-006229-7yoilsho	3701	7	levels	level	NNS
cord-006229-7yoilsho	3701	8	to	to	IN
cord-006229-7yoilsho	3701	9	metabolites	metabolite	NNS
cord-006229-7yoilsho	3701	10	of	of	IN
cord-006229-7yoilsho	3701	11	different	different	JJ
cord-006229-7yoilsho	3701	12	Phthalates	phthalate	NNS
cord-006229-7yoilsho	3701	13	and	and	CC
cord-006229-7yoilsho	3701	14	Parabens	paraben	NNS
cord-006229-7yoilsho	3701	15	as	as	RB
cord-006229-7yoilsho	3701	16	well	well	RB
cord-006229-7yoilsho	3701	17	as	as	IN
cord-006229-7yoilsho	3701	18	to	to	IN
cord-006229-7yoilsho	3701	19	Bisphenol	Bisphenol	NNP
cord-006229-7yoilsho	3701	20	A	A	NNP
cord-006229-7yoilsho	3701	21	and	and	CC
cord-006229-7yoilsho	3701	22	Triclosan	Triclosan	NNP
cord-006229-7yoilsho	3701	23	in	in	IN
cord-006229-7yoilsho	3701	24	urine	urine	NN
cord-006229-7yoilsho	3701	25	samples	sample	NNS
cord-006229-7yoilsho	3701	26	collected	collect	VBN
cord-006229-7yoilsho	3701	27	from	from	IN
cord-006229-7yoilsho	3701	28	preschool	preschool	NN
cord-006229-7yoilsho	3701	29	children	child	NNS
cord-006229-7yoilsho	3701	30	in	in	IN
cord-006229-7yoilsho	3701	31	German	german	JJ
cord-006229-7yoilsho	3701	32	day	day	NN
cord-006229-7yoilsho	3701	33	-	-	HYPH
cord-006229-7yoilsho	3701	34	care	care	NN
cord-006229-7yoilsho	3701	35	centers	center	NNS
cord-006229-7yoilsho	3701	36	from	from	IN
cord-006229-7yoilsho	3701	37	North	North	NNP
cord-006229-7yoilsho	3701	38	Rhine	Rhine	NNP
cord-006229-7yoilsho	3701	39	-	-	HYPH
cord-006229-7yoilsho	3701	40	Westphalia	Westphalia	NNP
cord-006229-7yoilsho	3701	41	(	(	-LRB-
cord-006229-7yoilsho	3701	42	LUPE	LUPE	NNP
cord-006229-7yoilsho	3701	43	III	III	NNP
cord-006229-7yoilsho	3701	44	;	;	:
cord-006229-7yoilsho	3701	45	2011/12	2011/12	CD
cord-006229-7yoilsho	3701	46	)	)	-RRB-
cord-006229-7yoilsho	3701	47	.	.	.
cord-006229-7yoilsho	3702	1	Urine	urine	NN
cord-006229-7yoilsho	3702	2	specimens	specimen	NNS
cord-006229-7yoilsho	3702	3	from	from	IN
cord-006229-7yoilsho	3702	4	children	child	NNS
cord-006229-7yoilsho	3702	5	aged	age	VBN
cord-006229-7yoilsho	3702	6	from	from	IN
cord-006229-7yoilsho	3702	7	20	20	CD
cord-006229-7yoilsho	3702	8	to	to	TO
cord-006229-7yoilsho	3702	9	80	80	CD
cord-006229-7yoilsho	3702	10	months	month	NNS
cord-006229-7yoilsho	3702	11	from	from	IN
cord-006229-7yoilsho	3702	12	23	23	CD
cord-006229-7yoilsho	3702	13	different	different	JJ
cord-006229-7yoilsho	3702	14	day	day	NN
cord-006229-7yoilsho	3702	15	-	-	HYPH
cord-006229-7yoilsho	3702	16	care	care	NN
cord-006229-7yoilsho	3702	17	centers	center	NNS
cord-006229-7yoilsho	3702	18	were	be	VBD
cord-006229-7yoilsho	3702	19	analyzed	analyze	VBN
cord-006229-7yoilsho	3702	20	.	.	.
cord-006229-7yoilsho	3703	1	In	in	IN
cord-006229-7yoilsho	3703	2	total	total	NN
cord-006229-7yoilsho	3703	3	,	,	,
cord-006229-7yoilsho	3703	4	253	253	CD
cord-006229-7yoilsho	3703	5	preschool	preschool	NN
cord-006229-7yoilsho	3703	6	children	child	NNS
cord-006229-7yoilsho	3703	7	were	be	VBD
cord-006229-7yoilsho	3703	8	recruited	recruit	VBN
cord-006229-7yoilsho	3703	9	with	with	IN
cord-006229-7yoilsho	3703	10	mean	mean	JJ
cord-006229-7yoilsho	3703	11	age	age	NN
cord-006229-7yoilsho	3703	12	of	of	IN
cord-006229-7yoilsho	3703	13	54	54	CD
cord-006229-7yoilsho	3703	14	months	month	NNS
cord-006229-7yoilsho	3703	15	.	.	.
cord-006229-7yoilsho	3704	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	3704	2	study	study	NN
cord-006229-7yoilsho	3704	3	results	result	NNS
cord-006229-7yoilsho	3704	4	show	show	VBP
cord-006229-7yoilsho	3704	5	that	that	IN
cord-006229-7yoilsho	3704	6	nearly	nearly	RB
cord-006229-7yoilsho	3704	7	all	all	DT
cord-006229-7yoilsho	3704	8	children	child	NNS
cord-006229-7yoilsho	3704	9	(	(	-LRB-
cord-006229-7yoilsho	3704	10	>	>	NFP
cord-006229-7yoilsho	3704	11	95	95	CD
cord-006229-7yoilsho	3704	12	%	%	NN
cord-006229-7yoilsho	3704	13	)	)	-RRB-
cord-006229-7yoilsho	3704	14	of	of	IN
cord-006229-7yoilsho	3704	15	the	the	DT
cord-006229-7yoilsho	3704	16	study	study	NN
cord-006229-7yoilsho	3704	17	population	population	NN
cord-006229-7yoilsho	3704	18	had	have	VBD
cord-006229-7yoilsho	3704	19	urine	urine	NN
cord-006229-7yoilsho	3704	20	concentrations	concentration	NNS
cord-006229-7yoilsho	3704	21	equal	equal	JJ
cord-006229-7yoilsho	3704	22	to	to	IN
cord-006229-7yoilsho	3704	23	or	or	CC
cord-006229-7yoilsho	3704	24	above	above	IN
cord-006229-7yoilsho	3704	25	the	the	DT
cord-006229-7yoilsho	3704	26	limit	limit	NN
cord-006229-7yoilsho	3704	27	of	of	IN
cord-006229-7yoilsho	3704	28	quantification	quantification	NN
cord-006229-7yoilsho	3704	29	for	for	IN
cord-006229-7yoilsho	3704	30	five	five	CD
cord-006229-7yoilsho	3704	31	most	most	RBS
cord-006229-7yoilsho	3704	32	common	common	JJ
cord-006229-7yoilsho	3704	33	Phthalates	phthalate	NNS
cord-006229-7yoilsho	3704	34	metabolites	metabolite	NNS
cord-006229-7yoilsho	3704	35	(	(	-LRB-
cord-006229-7yoilsho	3704	36	MnBP	MnBP	NNP
cord-006229-7yoilsho	3704	37	,	,	,
cord-006229-7yoilsho	3704	38	MiBP	MiBP	NNP
cord-006229-7yoilsho	3704	39	,	,	,
cord-006229-7yoilsho	3704	40	5OH	5OH	NNP
cord-006229-7yoilsho	3704	41	-	-	HYPH
cord-006229-7yoilsho	3704	42	MEHP	MEHP	NNP
cord-006229-7yoilsho	3704	43	,	,	,
cord-006229-7yoilsho	3704	44	5oxo	5oxo	CD
cord-006229-7yoilsho	3704	45	-	-	HYPH
cord-006229-7yoilsho	3704	46	MEHP	MEHP	NNP
cord-006229-7yoilsho	3704	47	,	,	,
cord-006229-7yoilsho	3704	48	7oxo	7oxo	CD
cord-006229-7yoilsho	3704	49	-	-	HYPH
cord-006229-7yoilsho	3704	50	MiNP	MiNP	NNP
cord-006229-7yoilsho	3704	51	)	)	-RRB-
cord-006229-7yoilsho	3704	52	,	,	,
cord-006229-7yoilsho	3704	53	for	for	IN
cord-006229-7yoilsho	3704	54	Bisphenol	Bisphenol	NNP
cord-006229-7yoilsho	3704	55	A	A	NNP
cord-006229-7yoilsho	3704	56	and	and	CC
cord-006229-7yoilsho	3704	57	Methylparaben	Methylparaben	NNP
cord-006229-7yoilsho	3704	58	.	.	.
cord-006229-7yoilsho	3705	1	Triclosan	Triclosan	NNP
cord-006229-7yoilsho	3705	2	was	be	VBD
cord-006229-7yoilsho	3705	3	detected	detect	VBN
cord-006229-7yoilsho	3705	4	in	in	IN
cord-006229-7yoilsho	3705	5	16	16	CD
cord-006229-7yoilsho	3705	6	%	%	NN
cord-006229-7yoilsho	3705	7	of	of	IN
cord-006229-7yoilsho	3705	8	the	the	DT
cord-006229-7yoilsho	3705	9	study	study	NN
cord-006229-7yoilsho	3705	10	population	population	NN
cord-006229-7yoilsho	3705	11	.	.	.
cord-006229-7yoilsho	3706	1	In	in	IN
cord-006229-7yoilsho	3706	2	general	general	JJ
cord-006229-7yoilsho	3706	3	,	,	,
cord-006229-7yoilsho	3706	4	the	the	DT
cord-006229-7yoilsho	3706	5	median	median	JJ
cord-006229-7yoilsho	3706	6	urinary	urinary	JJ
cord-006229-7yoilsho	3706	7	concentrations	concentration	NNS
cord-006229-7yoilsho	3706	8	of	of	IN
cord-006229-7yoilsho	3706	9	the	the	DT
cord-006229-7yoilsho	3706	10	above	above	RB
cord-006229-7yoilsho	3706	11	mentioned	mention	VBN
cord-006229-7yoilsho	3706	12	Phthalate	Phthalate	NNP
cord-006229-7yoilsho	3706	13	metabolites	metabolite	NNS
cord-006229-7yoilsho	3706	14	were	be	VBD
cord-006229-7yoilsho	3706	15	about	about	RB
cord-006229-7yoilsho	3706	16	5	5	CD
cord-006229-7yoilsho	3706	17	-	-	SYM
cord-006229-7yoilsho	3706	18	50	50	CD
cord-006229-7yoilsho	3706	19	µg	µg	NN
cord-006229-7yoilsho	3706	20	/	/	SYM
cord-006229-7yoilsho	3706	21	l	l	NN
cord-006229-7yoilsho	3706	22	in	in	IN
cord-006229-7yoilsho	3706	23	spot	spot	NN
cord-006229-7yoilsho	3706	24	urine	urine	NN
cord-006229-7yoilsho	3706	25	samples	sample	NNS
cord-006229-7yoilsho	3706	26	.	.	.
cord-006229-7yoilsho	3707	1	The	the	DT
cord-006229-7yoilsho	3707	2	highest	high	JJS
cord-006229-7yoilsho	3707	3	amount	amount	NN
cord-006229-7yoilsho	3707	4	among	among	IN
cord-006229-7yoilsho	3707	5	the	the	DT
cord-006229-7yoilsho	3707	6	Phthalate	Phthalate	NNP
cord-006229-7yoilsho	3707	7	metabolites	metabolite	NNS
cord-006229-7yoilsho	3707	8	was	be	VBD
cord-006229-7yoilsho	3707	9	observed	observe	VBN
cord-006229-7yoilsho	3707	10	for	for	IN
cord-006229-7yoilsho	3707	11	MiBP	mibp	NN
cord-006229-7yoilsho	3707	12	with	with	IN
cord-006229-7yoilsho	3707	13	maximal	maximal	JJ
cord-006229-7yoilsho	3707	14	values	value	NNS
cord-006229-7yoilsho	3707	15	of	of	IN
cord-006229-7yoilsho	3707	16	about	about	RB
cord-006229-7yoilsho	3707	17	1000	1000	CD
cord-006229-7yoilsho	3708	1	µg	µg	NNP
cord-006229-7yoilsho	3708	2	/	/	SYM
cord-006229-7yoilsho	3708	3	l	l	NN
cord-006229-7yoilsho	3708	4	.	.	.
cord-006229-7yoilsho	3709	1	Median	median	JJ
cord-006229-7yoilsho	3709	2	urinary	urinary	JJ
cord-006229-7yoilsho	3709	3	concentration	concentration	NN
cord-006229-7yoilsho	3709	4	for	for	IN
cord-006229-7yoilsho	3709	5	Methylparaben	Methylparaben	NNP
cord-006229-7yoilsho	3709	6	and	and	CC
cord-006229-7yoilsho	3709	7	Bisphenol	Bisphenol	NNP
cord-006229-7yoilsho	3709	8	A	A	NNP
cord-006229-7yoilsho	3709	9	were	be	VBD
cord-006229-7yoilsho	3709	10	about	about	RB
cord-006229-7yoilsho	3709	11	48	48	CD
cord-006229-7yoilsho	3709	12	µg	µg	NNS
cord-006229-7yoilsho	3709	13	/	/	SYM
cord-006229-7yoilsho	3709	14	l	l	NN
cord-006229-7yoilsho	3709	15	and	and	CC
cord-006229-7yoilsho	3709	16	2	2	CD
cord-006229-7yoilsho	3709	17	µg	µg	NN
cord-006229-7yoilsho	3709	18	/	/	SYM
cord-006229-7yoilsho	3709	19	l	l	NN
cord-006229-7yoilsho	3709	20	respectively	respectively	RB
cord-006229-7yoilsho	3709	21	.	.	.
cord-006229-7yoilsho	3710	1	The	the	DT
cord-006229-7yoilsho	3710	2	maximum	maximum	JJ
cord-006229-7yoilsho	3710	3	Methylparaben	methylparaben	NN
cord-006229-7yoilsho	3710	4	,	,	,
cord-006229-7yoilsho	3710	5	Bisphenol	Bisphenol	NNP
cord-006229-7yoilsho	3710	6	A	A	NNP
cord-006229-7yoilsho	3710	7	and	and	CC
cord-006229-7yoilsho	3710	8	Triclosan	Triclosan	NNP
cord-006229-7yoilsho	3710	9	level	level	NN
cord-006229-7yoilsho	3710	10	found	find	VBN
cord-006229-7yoilsho	3710	11	were	be	VBD
cord-006229-7yoilsho	3710	12	1770	1770	CD
cord-006229-7yoilsho	3710	13	µg	µg	NN
cord-006229-7yoilsho	3710	14	/	/	SYM
cord-006229-7yoilsho	3710	15	l	l	NN
cord-006229-7yoilsho	3710	16	,	,	,
cord-006229-7yoilsho	3710	17	72.4	72.4	CD
cord-006229-7yoilsho	3710	18	µg	µg	NN
cord-006229-7yoilsho	3710	19	/	/	SYM
cord-006229-7yoilsho	3710	20	l	l	NN
cord-006229-7yoilsho	3710	21	and	and	CC
cord-006229-7yoilsho	3710	22	55,6	55,6	CD
cord-006229-7yoilsho	3711	1	µg	µg	NNP
cord-006229-7yoilsho	3711	2	/	/	SYM
cord-006229-7yoilsho	3711	3	l	l	NNP
cord-006229-7yoilsho	3711	4	respectively	respectively	RB
cord-006229-7yoilsho	3711	5	.	.	.
cord-006229-7yoilsho	3712	1	In	in	IN
cord-006229-7yoilsho	3712	2	conclusion	conclusion	NN
cord-006229-7yoilsho	3712	3	,	,	,
cord-006229-7yoilsho	3712	4	our	-PRON-	PRP$
cord-006229-7yoilsho	3712	5	study	study	NN
cord-006229-7yoilsho	3712	6	shows	show	VBZ
cord-006229-7yoilsho	3712	7	a	a	DT
cord-006229-7yoilsho	3712	8	widespread	widespread	JJ
cord-006229-7yoilsho	3712	9	exposure	exposure	NN
cord-006229-7yoilsho	3712	10	of	of	IN
cord-006229-7yoilsho	3712	11	young	young	JJ
cord-006229-7yoilsho	3712	12	children	child	NNS
cord-006229-7yoilsho	3712	13	to	to	IN
cord-006229-7yoilsho	3712	14	various	various	JJ
cord-006229-7yoilsho	3712	15	Phthalates	phthalate	NNS
cord-006229-7yoilsho	3712	16	,	,	,
cord-006229-7yoilsho	3712	17	Parabens	paraben	NNS
cord-006229-7yoilsho	3712	18	and	and	CC
cord-006229-7yoilsho	3712	19	Bisphenol	Bisphenol	NNP
cord-006229-7yoilsho	3712	20	A	A	NNP
cord-006229-7yoilsho	3712	21	in	in	IN
cord-006229-7yoilsho	3712	22	North	North	NNP
cord-006229-7yoilsho	3712	23	Rhine	Rhine	NNP
cord-006229-7yoilsho	3712	24	-	-	HYPH
cord-006229-7yoilsho	3712	25	Westphalia	Westphalia	NNP
cord-006229-7yoilsho	3712	26	,	,	,
cord-006229-7yoilsho	3712	27	Germany	Germany	NNP
cord-006229-7yoilsho	3712	28	.	.	.
cord-006229-7yoilsho	3713	1	A	a	DT
cord-006229-7yoilsho	3713	2	follow	follow	VB
cord-006229-7yoilsho	3713	3	-	-	HYPH
cord-006229-7yoilsho	3713	4	up	up	RP
cord-006229-7yoilsho	3713	5	human	human	JJ
cord-006229-7yoilsho	3713	6	biomonitoring	biomonitoring	NN
cord-006229-7yoilsho	3713	7	study	study	NN
cord-006229-7yoilsho	3713	8	(	(	-LRB-
cord-006229-7yoilsho	3713	9	2014/2015	2014/2015	CD
cord-006229-7yoilsho	3713	10	)	)	-RRB-
cord-006229-7yoilsho	3713	11	has	have	VBZ
cord-006229-7yoilsho	3713	12	finished	finish	VBN
cord-006229-7yoilsho	3713	13	recruitment	recruitment	NN
cord-006229-7yoilsho	3713	14	and	and	CC
cord-006229-7yoilsho	3713	15	is	be	VBZ
cord-006229-7yoilsho	3713	16	in	in	IN
cord-006229-7yoilsho	3713	17	the	the	DT
cord-006229-7yoilsho	3713	18	process	process	NN
cord-006229-7yoilsho	3713	19	of	of	IN
cord-006229-7yoilsho	3713	20	analyzing	analyze	VBG
cord-006229-7yoilsho	3713	21	data	datum	NNS
cord-006229-7yoilsho	3713	22	.	.	.
cord-006229-7yoilsho	3714	1	Polycyclic	polycyclic	JJ
cord-006229-7yoilsho	3714	2	aromatic	aromatic	JJ
cord-006229-7yoilsho	3714	3	hydrocarbons	hydrocarbon	NNS
cord-006229-7yoilsho	3714	4	(	(	-LRB-
cord-006229-7yoilsho	3714	5	PAHs	pah	NNS
cord-006229-7yoilsho	3714	6	)	)	-RRB-
cord-006229-7yoilsho	3714	7	represent	represent	VBP
cord-006229-7yoilsho	3714	8	a	a	DT
cord-006229-7yoilsho	3714	9	large	large	JJ
cord-006229-7yoilsho	3714	10	group	group	NN
cord-006229-7yoilsho	3714	11	of	of	IN
cord-006229-7yoilsho	3714	12	organic	organic	JJ
cord-006229-7yoilsho	3714	13	compounds	compound	NNS
cord-006229-7yoilsho	3714	14	that	that	WDT
cord-006229-7yoilsho	3714	15	are	be	VBP
cord-006229-7yoilsho	3714	16	common	common	JJ
cord-006229-7yoilsho	3714	17	environmental	environmental	JJ
cord-006229-7yoilsho	3714	18	contaminants	contaminant	NNS
cord-006229-7yoilsho	3714	19	.	.	.
cord-006229-7yoilsho	3715	1	They	-PRON-	PRP
cord-006229-7yoilsho	3715	2	are	be	VBP
cord-006229-7yoilsho	3715	3	formed	form	VBN
cord-006229-7yoilsho	3715	4	by	by	IN
cord-006229-7yoilsho	3715	5	incomplete	incomplete	JJ
cord-006229-7yoilsho	3715	6	combustion	combustion	NN
cord-006229-7yoilsho	3715	7	of	of	IN
cord-006229-7yoilsho	3715	8	organic	organic	JJ
cord-006229-7yoilsho	3715	9	matter	matter	NN
cord-006229-7yoilsho	3715	10	such	such	JJ
cord-006229-7yoilsho	3715	11	as	as	IN
cord-006229-7yoilsho	3715	12	coal	coal	NN
cord-006229-7yoilsho	3715	13	or	or	CC
cord-006229-7yoilsho	3715	14	crude	crude	JJ
cord-006229-7yoilsho	3715	15	oil	oil	NN
cord-006229-7yoilsho	3715	16	and	and	CC
cord-006229-7yoilsho	3715	17	are	be	VBP
cord-006229-7yoilsho	3715	18	often	often	RB
cord-006229-7yoilsho	3715	19	known	know	VBN
cord-006229-7yoilsho	3715	20	to	to	TO
cord-006229-7yoilsho	3715	21	be	be	VB
cord-006229-7yoilsho	3715	22	carcinogenic	carcinogenic	JJ
cord-006229-7yoilsho	3715	23	,	,	,
cord-006229-7yoilsho	3715	24	mutagenic	mutagenic	JJ
cord-006229-7yoilsho	3715	25	and	and	CC
cord-006229-7yoilsho	3715	26	teratogenic	teratogenic	JJ
cord-006229-7yoilsho	3715	27	.	.	.
cord-006229-7yoilsho	3716	1	The	the	DT
cord-006229-7yoilsho	3716	2	acute	acute	JJ
cord-006229-7yoilsho	3716	3	toxicity	toxicity	NN
cord-006229-7yoilsho	3716	4	of	of	IN
cord-006229-7yoilsho	3716	5	PAHs	pah	NNS
cord-006229-7yoilsho	3716	6	is	be	VBZ
cord-006229-7yoilsho	3716	7	rather	rather	RB
cord-006229-7yoilsho	3716	8	low	low	JJ
cord-006229-7yoilsho	3716	9	,	,	,
cord-006229-7yoilsho	3716	10	but	but	CC
cord-006229-7yoilsho	3716	11	because	because	IN
cord-006229-7yoilsho	3716	12	of	of	IN
cord-006229-7yoilsho	3716	13	their	-PRON-	PRP$
cord-006229-7yoilsho	3716	14	stability	stability	NN
cord-006229-7yoilsho	3716	15	and	and	CC
cord-006229-7yoilsho	3716	16	lipophilic	lipophilic	JJ
cord-006229-7yoilsho	3716	17	character	character	NN
cord-006229-7yoilsho	3716	18	those	those	DT
cord-006229-7yoilsho	3716	19	compounds	compound	NNS
cord-006229-7yoilsho	3716	20	can	can	MD
cord-006229-7yoilsho	3716	21	accumulate	accumulate	VB
cord-006229-7yoilsho	3716	22	in	in	IN
cord-006229-7yoilsho	3716	23	the	the	DT
cord-006229-7yoilsho	3716	24	human	human	JJ
cord-006229-7yoilsho	3716	25	body	body	NN
cord-006229-7yoilsho	3716	26	and	and	CC
cord-006229-7yoilsho	3716	27	cause	cause	VB
cord-006229-7yoilsho	3716	28	severe	severe	JJ
cord-006229-7yoilsho	3716	29	chronic	chronic	JJ
cord-006229-7yoilsho	3716	30	effects	effect	NNS
cord-006229-7yoilsho	3716	31	.	.	.
cord-006229-7yoilsho	3717	1	Additionally	additionally	RB
cord-006229-7yoilsho	3717	2	PAHs	pah	NNS
cord-006229-7yoilsho	3717	3	may	may	MD
cord-006229-7yoilsho	3717	4	enter	enter	VB
cord-006229-7yoilsho	3717	5	the	the	DT
cord-006229-7yoilsho	3717	6	food	food	NN
cord-006229-7yoilsho	3717	7	chain	chain	NN
cord-006229-7yoilsho	3717	8	when	when	WRB
cord-006229-7yoilsho	3717	9	preserving	preserve	VBG
cord-006229-7yoilsho	3717	10	meat	meat	NN
cord-006229-7yoilsho	3717	11	or	or	CC
cord-006229-7yoilsho	3717	12	fish	fish	NN
cord-006229-7yoilsho	3717	13	by	by	IN
cord-006229-7yoilsho	3717	14	exposure	exposure	NN
cord-006229-7yoilsho	3717	15	to	to	IN
cord-006229-7yoilsho	3717	16	smoke	smoke	NN
cord-006229-7yoilsho	3717	17	.	.	.
cord-006229-7yoilsho	3718	1	In	in	IN
cord-006229-7yoilsho	3718	2	the	the	DT
cord-006229-7yoilsho	3718	3	European	European	NNP
cord-006229-7yoilsho	3718	4	Union	Union	NNP
cord-006229-7yoilsho	3718	5	maximum	maximum	JJ
cord-006229-7yoilsho	3718	6	levels	level	NNS
cord-006229-7yoilsho	3718	7	of	of	IN
cord-006229-7yoilsho	3718	8	2	2	CD
cord-006229-7yoilsho	3718	9	µg	µg	NN
cord-006229-7yoilsho	3718	10	/	/	SYM
cord-006229-7yoilsho	3718	11	kg	kg	NN
cord-006229-7yoilsho	3718	12	benzo[a]pyrene	benzo[a]pyrene	CD
cord-006229-7yoilsho	3718	13	and	and	CC
cord-006229-7yoilsho	3718	14	12	12	CD
cord-006229-7yoilsho	3718	15	µg	µg	NN
cord-006229-7yoilsho	3718	16	/	/	SYM
cord-006229-7yoilsho	3718	17	kg	kg	NN
cord-006229-7yoilsho	3718	18	as	as	IN
cord-006229-7yoilsho	3718	19	the	the	DT
cord-006229-7yoilsho	3718	20	sum	sum	NN
cord-006229-7yoilsho	3718	21	of	of	IN
cord-006229-7yoilsho	3718	22	benzo[a]pyrene	benzo[a]pyrene	NN
cord-006229-7yoilsho	3718	23	,	,	,
cord-006229-7yoilsho	3718	24	benz[a]anthracene	benz[a]anthracene	NNP
cord-006229-7yoilsho	3718	25	,	,	,
cord-006229-7yoilsho	3718	26	benzo[b]fluoranthene	benzo[b]fluoranthene	NN
cord-006229-7yoilsho	3718	27	and	and	CC
cord-006229-7yoilsho	3718	28	chrysene	chrysene	NN
cord-006229-7yoilsho	3718	29	in	in	IN
cord-006229-7yoilsho	3718	30	the	the	DT
cord-006229-7yoilsho	3718	31	meat	meat	NN
cord-006229-7yoilsho	3718	32	of	of	IN
cord-006229-7yoilsho	3718	33	smoked	smoke	VBN
cord-006229-7yoilsho	3718	34	fish	fish	NN
cord-006229-7yoilsho	3718	35	and	and	CC
cord-006229-7yoilsho	3718	36	smoked	smoke	VBN
cord-006229-7yoilsho	3718	37	fishery	fishery	NN
cord-006229-7yoilsho	3718	38	products	product	NNS
cord-006229-7yoilsho	3718	39	are	be	VBP
cord-006229-7yoilsho	3718	40	set	set	VBN
cord-006229-7yoilsho	3718	41	,	,	,
cord-006229-7yoilsho	3718	42	respectively	respectively	RB
cord-006229-7yoilsho	3718	43	.	.	.
cord-006229-7yoilsho	3719	1	Smoked	smoke	VBN
cord-006229-7yoilsho	3719	2	fish	fish	NN
cord-006229-7yoilsho	3719	3	is	be	VBZ
cord-006229-7yoilsho	3719	4	often	often	RB
cord-006229-7yoilsho	3719	5	handmade	handmade	JJ
cord-006229-7yoilsho	3719	6	in	in	IN
cord-006229-7yoilsho	3719	7	small	small	JJ
cord-006229-7yoilsho	3719	8	fishery	fishery	NN
cord-006229-7yoilsho	3719	9	stores	store	NNS
cord-006229-7yoilsho	3719	10	in	in	IN
cord-006229-7yoilsho	3719	11	Schleswig	Schleswig	NNP
cord-006229-7yoilsho	3719	12	-	-	HYPH
cord-006229-7yoilsho	3719	13	Holstein	Holstein	NNP
cord-006229-7yoilsho	3719	14	,	,	,
cord-006229-7yoilsho	3719	15	where	where	WRB
cord-006229-7yoilsho	3719	16	self	self	NN
cord-006229-7yoilsho	3719	17	caught	catch	VBD
cord-006229-7yoilsho	3719	18	fish	fish	NN
cord-006229-7yoilsho	3719	19	is	be	VBZ
cord-006229-7yoilsho	3719	20	prepared	prepare	VBN
cord-006229-7yoilsho	3719	21	in	in	IN
cord-006229-7yoilsho	3719	22	smoke	smoke	NN
cord-006229-7yoilsho	3719	23	houses	house	NNS
cord-006229-7yoilsho	3719	24	.	.	.
cord-006229-7yoilsho	3720	1	This	this	DT
cord-006229-7yoilsho	3720	2	technique	technique	NN
cord-006229-7yoilsho	3720	3	implies	imply	VBZ
cord-006229-7yoilsho	3720	4	the	the	DT
cord-006229-7yoilsho	3720	5	danger	danger	NN
cord-006229-7yoilsho	3720	6	of	of	IN
cord-006229-7yoilsho	3720	7	PAHs	pah	NNS
cord-006229-7yoilsho	3720	8	to	to	TO
cord-006229-7yoilsho	3720	9	accumulate	accumulate	VB
cord-006229-7yoilsho	3720	10	in	in	IN
cord-006229-7yoilsho	3720	11	smoked	smoke	VBN
cord-006229-7yoilsho	3720	12	fishery	fishery	NN
cord-006229-7yoilsho	3720	13	products	product	NNS
cord-006229-7yoilsho	3720	14	above	above	RB
cord-006229-7yoilsho	3720	15	allowed	allow	VBD
cord-006229-7yoilsho	3720	16	maximum	maximum	JJ
cord-006229-7yoilsho	3720	17	levels	level	NNS
cord-006229-7yoilsho	3720	18	.	.	.
cord-006229-7yoilsho	3721	1	Here	here	RB
cord-006229-7yoilsho	3721	2	,	,	,
cord-006229-7yoilsho	3721	3	we	-PRON-	PRP
cord-006229-7yoilsho	3721	4	report	report	VBP
cord-006229-7yoilsho	3721	5	our	-PRON-	PRP$
cord-006229-7yoilsho	3721	6	findings	finding	NNS
cord-006229-7yoilsho	3721	7	of	of	IN
cord-006229-7yoilsho	3721	8	PAHs	pah	NNS
cord-006229-7yoilsho	3721	9	in	in	IN
cord-006229-7yoilsho	3721	10	smoked	smoke	VBN
cord-006229-7yoilsho	3721	11	fishery	fishery	NN
cord-006229-7yoilsho	3721	12	products	product	NNS
cord-006229-7yoilsho	3721	13	bought	buy	VBN
cord-006229-7yoilsho	3721	14	in	in	IN
cord-006229-7yoilsho	3721	15	local	local	JJ
cord-006229-7yoilsho	3721	16	convenience	convenience	NN
cord-006229-7yoilsho	3721	17	and	and	CC
cord-006229-7yoilsho	3721	18	fishery	fishery	NN
cord-006229-7yoilsho	3721	19	stores	store	NNS
cord-006229-7yoilsho	3721	20	in	in	IN
cord-006229-7yoilsho	3721	21	Schleswig	Schleswig	NNP
cord-006229-7yoilsho	3721	22	-	-	HYPH
cord-006229-7yoilsho	3721	23	Holstein	Holstein	NNP
cord-006229-7yoilsho	3721	24	and	and	CC
cord-006229-7yoilsho	3721	25	give	give	VB
cord-006229-7yoilsho	3721	26	a	a	DT
cord-006229-7yoilsho	3721	27	brief	brief	JJ
cord-006229-7yoilsho	3721	28	overview	overview	NN
cord-006229-7yoilsho	3721	29	about	about	IN
cord-006229-7yoilsho	3721	30	actual	actual	JJ
cord-006229-7yoilsho	3721	31	contaminant	contaminant	NN
cord-006229-7yoilsho	3721	32	levels	level	NNS
cord-006229-7yoilsho	3721	33	.	.	.
cord-006229-7yoilsho	3722	1	HPLC	HPLC	NNP
cord-006229-7yoilsho	3722	2	with	with	IN
cord-006229-7yoilsho	3722	3	fluorescence	fluorescence	NN
cord-006229-7yoilsho	3722	4	detection	detection	NN
cord-006229-7yoilsho	3722	5	was	be	VBD
cord-006229-7yoilsho	3722	6	used	use	VBN
cord-006229-7yoilsho	3722	7	to	to	TO
cord-006229-7yoilsho	3722	8	determine	determine	VB
cord-006229-7yoilsho	3722	9	the	the	DT
cord-006229-7yoilsho	3722	10	quality	quality	NN
cord-006229-7yoilsho	3722	11	and	and	CC
cord-006229-7yoilsho	3722	12	quantity	quantity	NN
cord-006229-7yoilsho	3722	13	of	of	IN
cord-006229-7yoilsho	3722	14	several	several	JJ
cord-006229-7yoilsho	3722	15	toxic	toxic	JJ
cord-006229-7yoilsho	3722	16	PAHs	pah	NNS
cord-006229-7yoilsho	3722	17	in	in	IN
cord-006229-7yoilsho	3722	18	smoked	smoke	VBN
cord-006229-7yoilsho	3722	19	fishery	fishery	NN
cord-006229-7yoilsho	3722	20	products	product	NNS
cord-006229-7yoilsho	3722	21	made	make	VBN
cord-006229-7yoilsho	3722	22	locally	locally	RB
cord-006229-7yoilsho	3722	23	.	.	.
cord-006229-7yoilsho	3723	1	PAHs	pah	NNS
cord-006229-7yoilsho	3723	2	may	may	MD
cord-006229-7yoilsho	3723	3	constitute	constitute	VB
cord-006229-7yoilsho	3723	4	risks	risk	NNS
cord-006229-7yoilsho	3723	5	for	for	IN
cord-006229-7yoilsho	3723	6	human	human	JJ
cord-006229-7yoilsho	3723	7	health	health	NN
cord-006229-7yoilsho	3723	8	when	when	WRB
cord-006229-7yoilsho	3723	9	exposed	expose	VBN
cord-006229-7yoilsho	3723	10	to	to	IN
cord-006229-7yoilsho	3723	11	hazardous	hazardous	JJ
cord-006229-7yoilsho	3723	12	levels	level	NNS
cord-006229-7yoilsho	3723	13	and	and	CC
cord-006229-7yoilsho	3723	14	therefore	therefore	RB
cord-006229-7yoilsho	3723	15	it	-PRON-	PRP
cord-006229-7yoilsho	3723	16	is	be	VBZ
cord-006229-7yoilsho	3723	17	important	important	JJ
cord-006229-7yoilsho	3723	18	to	to	TO
cord-006229-7yoilsho	3723	19	have	have	VB
cord-006229-7yoilsho	3723	20	knowledge	knowledge	NN
cord-006229-7yoilsho	3723	21	about	about	IN
cord-006229-7yoilsho	3723	22	given	give	VBN
cord-006229-7yoilsho	3723	23	contaminant	contaminant	NN
cord-006229-7yoilsho	3723	24	levels	level	NNS
cord-006229-7yoilsho	3723	25	.	.	.
cord-006229-7yoilsho	3724	1	Colorectal	colorectal	JJ
cord-006229-7yoilsho	3724	2	cancer	cancer	NN
cord-006229-7yoilsho	3724	3	(	(	-LRB-
cord-006229-7yoilsho	3724	4	CRC	CRC	NNP
cord-006229-7yoilsho	3724	5	)	)	-RRB-
cord-006229-7yoilsho	3724	6	is	be	VBZ
cord-006229-7yoilsho	3724	7	one	one	CD
cord-006229-7yoilsho	3724	8	of	of	IN
cord-006229-7yoilsho	3724	9	the	the	DT
cord-006229-7yoilsho	3724	10	most	most	RBS
cord-006229-7yoilsho	3724	11	frequent	frequent	JJ
cord-006229-7yoilsho	3724	12	cancers	cancer	NNS
cord-006229-7yoilsho	3724	13	worldwide	worldwide	RB
cord-006229-7yoilsho	3724	14	and	and	CC
cord-006229-7yoilsho	3724	15	is	be	VBZ
cord-006229-7yoilsho	3724	16	tightly	tightly	RB
cord-006229-7yoilsho	3724	17	linked	link	VBN
cord-006229-7yoilsho	3724	18	to	to	IN
cord-006229-7yoilsho	3724	19	dietary	dietary	JJ
cord-006229-7yoilsho	3724	20	habits	habit	NNS
cord-006229-7yoilsho	3724	21	.	.	.
cord-006229-7yoilsho	3725	1	Epidemiological	epidemiological	JJ
cord-006229-7yoilsho	3725	2	studies	study	NNS
cord-006229-7yoilsho	3725	3	provided	provide	VBD
cord-006229-7yoilsho	3725	4	evidence	evidence	NN
cord-006229-7yoilsho	3725	5	that	that	IN
cord-006229-7yoilsho	3725	6	the	the	DT
cord-006229-7yoilsho	3725	7	intake	intake	NN
cord-006229-7yoilsho	3725	8	of	of	IN
cord-006229-7yoilsho	3725	9	red	red	JJ
cord-006229-7yoilsho	3725	10	meat	meat	NN
cord-006229-7yoilsho	3725	11	is	be	VBZ
cord-006229-7yoilsho	3725	12	associated	associate	VBN
cord-006229-7yoilsho	3725	13	with	with	IN
cord-006229-7yoilsho	3725	14	an	an	DT
cord-006229-7yoilsho	3725	15	increased	increase	VBN
cord-006229-7yoilsho	3725	16	risk	risk	NN
cord-006229-7yoilsho	3725	17	to	to	TO
cord-006229-7yoilsho	3725	18	develop	develop	VB
cord-006229-7yoilsho	3725	19	CRC	CRC	NNP
cord-006229-7yoilsho	3725	20	[	[	-LRB-
cord-006229-7yoilsho	3725	21	1	1	CD
cord-006229-7yoilsho	3725	22	]	]	-RRB-
cord-006229-7yoilsho	3725	23	.	.	.
cord-006229-7yoilsho	3726	1	Red	red	JJ
cord-006229-7yoilsho	3726	2	meat	meat	NN
cord-006229-7yoilsho	3726	3	contains	contain	VBZ
cord-006229-7yoilsho	3726	4	high	high	JJ
cord-006229-7yoilsho	3726	5	amounts	amount	NNS
cord-006229-7yoilsho	3726	6	of	of	IN
cord-006229-7yoilsho	3726	7	heme	heme	NN
cord-006229-7yoilsho	3726	8	iron	iron	NN
cord-006229-7yoilsho	3726	9	,	,	,
cord-006229-7yoilsho	3726	10	which	which	WDT
cord-006229-7yoilsho	3726	11	is	be	VBZ
cord-006229-7yoilsho	3726	12	thought	think	VBN
cord-006229-7yoilsho	3726	13	to	to	TO
cord-006229-7yoilsho	3726	14	play	play	VB
cord-006229-7yoilsho	3726	15	a	a	DT
cord-006229-7yoilsho	3726	16	causal	causal	JJ
cord-006229-7yoilsho	3726	17	role	role	NN
cord-006229-7yoilsho	3726	18	in	in	IN
cord-006229-7yoilsho	3726	19	tumor	tumor	NN
cord-006229-7yoilsho	3726	20	formation	formation	NN
cord-006229-7yoilsho	3726	21	.	.	.
cord-006229-7yoilsho	3727	1	The	the	DT
cord-006229-7yoilsho	3727	2	underlying	underlying	JJ
cord-006229-7yoilsho	3727	3	molecular	molecular	JJ
cord-006229-7yoilsho	3727	4	mechanism	mechanism	NN
cord-006229-7yoilsho	3727	5	,	,	,
cord-006229-7yoilsho	3727	6	however	however	RB
cord-006229-7yoilsho	3727	7	,	,	,
cord-006229-7yoilsho	3727	8	remains	remain	VBZ
cord-006229-7yoilsho	3727	9	elusive	elusive	JJ
cord-006229-7yoilsho	3727	10	and	and	CC
cord-006229-7yoilsho	3727	11	may	may	MD
cord-006229-7yoilsho	3727	12	involve	involve	VB
cord-006229-7yoilsho	3727	13	increased	increase	VBN
cord-006229-7yoilsho	3727	14	cell	cell	NN
cord-006229-7yoilsho	3727	15	proliferation	proliferation	NN
cord-006229-7yoilsho	3727	16	and	and	CC
cord-006229-7yoilsho	3727	17	DNA	dna	NN
cord-006229-7yoilsho	3727	18	damage	damage	NN
cord-006229-7yoilsho	3727	19	induction	induction	NN
cord-006229-7yoilsho	3727	20	by	by	IN
cord-006229-7yoilsho	3727	21	heme	heme	NN
cord-006229-7yoilsho	3727	22	-	-	HYPH
cord-006229-7yoilsho	3727	23	iron	iron	NN
cord-006229-7yoilsho	3727	24	.	.	.
cord-006229-7yoilsho	3728	1	In	in	IN
cord-006229-7yoilsho	3728	2	this	this	DT
cord-006229-7yoilsho	3728	3	study	study	NN
cord-006229-7yoilsho	3728	4	,	,	,
cord-006229-7yoilsho	3728	5	we	-PRON-	PRP
cord-006229-7yoilsho	3728	6	set	set	VBD
cord-006229-7yoilsho	3728	7	out	out	RP
cord-006229-7yoilsho	3728	8	to	to	TO
cord-006229-7yoilsho	3728	9	analyze	analyze	VB
cord-006229-7yoilsho	3728	10	the	the	DT
cord-006229-7yoilsho	3728	11	genotoxic	genotoxic	JJ
cord-006229-7yoilsho	3728	12	and	and	CC
cord-006229-7yoilsho	3728	13	cytotoxic	cytotoxic	JJ
cord-006229-7yoilsho	3728	14	effects	effect	NNS
cord-006229-7yoilsho	3728	15	of	of	IN
cord-006229-7yoilsho	3728	16	heme	heme	NN
cord-006229-7yoilsho	3728	17	-	-	HYPH
cord-006229-7yoilsho	3728	18	iron	iron	NN
cord-006229-7yoilsho	3728	19	in	in	IN
cord-006229-7yoilsho	3728	20	human	human	JJ
cord-006229-7yoilsho	3728	21	colonic	colonic	JJ
cord-006229-7yoilsho	3728	22	epithelial	epithelial	JJ
cord-006229-7yoilsho	3728	23	cell	cell	NN
cord-006229-7yoilsho	3728	24	lines	line	NNS
cord-006229-7yoilsho	3728	25	.	.	.
cord-006229-7yoilsho	3729	1	We	-PRON-	PRP
cord-006229-7yoilsho	3729	2	used	use	VBD
cord-006229-7yoilsho	3729	3	hemin	hemin	NNP
cord-006229-7yoilsho	3729	4	(	(	-LRB-
cord-006229-7yoilsho	3729	5	Fe	Fe	NNP
cord-006229-7yoilsho	3729	6	III	III	NNP
cord-006229-7yoilsho	3729	7	)	)	-RRB-
cord-006229-7yoilsho	3729	8	as	as	RB
cord-006229-7yoilsho	3729	9	commercially	commercially	RB
cord-006229-7yoilsho	3729	10	available	available	JJ
cord-006229-7yoilsho	3729	11	heme	heme	NN
cord-006229-7yoilsho	3729	12	source	source	NN
cord-006229-7yoilsho	3729	13	,	,	,
cord-006229-7yoilsho	3729	14	which	which	WDT
cord-006229-7yoilsho	3729	15	was	be	VBD
cord-006229-7yoilsho	3729	16	compared	compare	VBN
cord-006229-7yoilsho	3729	17	to	to	IN
cord-006229-7yoilsho	3729	18	inorganic	inorganic	JJ
cord-006229-7yoilsho	3729	19	iron	iron	NN
cord-006229-7yoilsho	3729	20	chloride	chloride	NN
cord-006229-7yoilsho	3729	21	(	(	-LRB-
cord-006229-7yoilsho	3729	22	FeCl	FeCl	NNP
cord-006229-7yoilsho	3729	23	3	3	CD
cord-006229-7yoilsho	3729	24	)	)	-RRB-
cord-006229-7yoilsho	3729	25	.	.	.
cord-006229-7yoilsho	3730	1	First	first	RB
cord-006229-7yoilsho	3730	2	,	,	,
cord-006229-7yoilsho	3730	3	the	the	DT
cord-006229-7yoilsho	3730	4	time	time	NN
cord-006229-7yoilsho	3730	5	-	-	HYPH
cord-006229-7yoilsho	3730	6	dependent	dependent	JJ
cord-006229-7yoilsho	3730	7	internalization	internalization	NN
cord-006229-7yoilsho	3730	8	of	of	IN
cord-006229-7yoilsho	3730	9	hemin	hemin	NN
cord-006229-7yoilsho	3730	10	and	and	CC
cord-006229-7yoilsho	3730	11	FeCl	FeCl	NNP
cord-006229-7yoilsho	3730	12	3	3	CD
cord-006229-7yoilsho	3730	13	into	into	IN
cord-006229-7yoilsho	3730	14	HCT116	hct116	JJ
cord-006229-7yoilsho	3730	15	cells	cell	NNS
cord-006229-7yoilsho	3730	16	was	be	VBD
cord-006229-7yoilsho	3730	17	determined	determine	VBN
cord-006229-7yoilsho	3730	18	using	use	VBG
cord-006229-7yoilsho	3730	19	ICP	ICP	NNP
cord-006229-7yoilsho	3730	20	-	-	HYPH
cord-006229-7yoilsho	3730	21	MS	MS	NNP
cord-006229-7yoilsho	3730	22	/	/	SYM
cord-006229-7yoilsho	3730	23	MS	MS	NNP
cord-006229-7yoilsho	3730	24	analysis	analysis	NN
cord-006229-7yoilsho	3730	25	.	.	.
cord-006229-7yoilsho	3731	1	Treatment	treatment	NN
cord-006229-7yoilsho	3731	2	of	of	IN
cord-006229-7yoilsho	3731	3	cells	cell	NNS
cord-006229-7yoilsho	3731	4	with	with	IN
cord-006229-7yoilsho	3731	5	inorganic	inorganic	JJ
cord-006229-7yoilsho	3731	6	iron	iron	NN
cord-006229-7yoilsho	3731	7	resulted	result	VBD
cord-006229-7yoilsho	3731	8	in	in	IN
cord-006229-7yoilsho	3731	9	a	a	DT
cord-006229-7yoilsho	3731	10	maximum	maximum	NN
cord-006229-7yoilsho	3731	11	of	of	IN
cord-006229-7yoilsho	3731	12	intracellular	intracellular	JJ
cord-006229-7yoilsho	3731	13	iron	iron	NN
cord-006229-7yoilsho	3731	14	content	content	NN
cord-006229-7yoilsho	3731	15	after	after	IN
cord-006229-7yoilsho	3731	16	1	1	CD
cord-006229-7yoilsho	3731	17	h	h	NN
cord-006229-7yoilsho	3731	18	at	at	IN
cord-006229-7yoilsho	3731	19	all	all	DT
cord-006229-7yoilsho	3731	20	doses	dose	NNS
cord-006229-7yoilsho	3731	21	tested	test	VBN
cord-006229-7yoilsho	3731	22	,	,	,
cord-006229-7yoilsho	3731	23	while	while	IN
cord-006229-7yoilsho	3731	24	hemin	hemin	NNP
cord-006229-7yoilsho	3731	25	particularly	particularly	RB
cord-006229-7yoilsho	3731	26	at	at	IN
cord-006229-7yoilsho	3731	27	high	high	JJ
cord-006229-7yoilsho	3731	28	doses	dose	NNS
cord-006229-7yoilsho	3731	29	caused	cause	VBD
cord-006229-7yoilsho	3731	30	an	an	DT
cord-006229-7yoilsho	3731	31	iron	iron	NN
cord-006229-7yoilsho	3731	32	accumulation	accumulation	NN
cord-006229-7yoilsho	3732	1	up	up	IN
cord-006229-7yoilsho	3732	2	to	to	TO
cord-006229-7yoilsho	3732	3	24	24	CD
cord-006229-7yoilsho	3732	4	h.	h.	NN
cord-006229-7yoilsho	3732	5	Hemin	Hemin	NNP
cord-006229-7yoilsho	3732	6	catalyzed	catalyze	VBD
cord-006229-7yoilsho	3732	7	the	the	DT
cord-006229-7yoilsho	3732	8	formation	formation	NN
cord-006229-7yoilsho	3732	9	of	of	IN
cord-006229-7yoilsho	3732	10	reactive	reactive	JJ
cord-006229-7yoilsho	3732	11	oxygen	oxygen	NN
cord-006229-7yoilsho	3732	12	species	specie	NNS
cord-006229-7yoilsho	3732	13	(	(	-LRB-
cord-006229-7yoilsho	3732	14	ROS	ROS	NNP
cord-006229-7yoilsho	3732	15	)	)	-RRB-
cord-006229-7yoilsho	3732	16	in	in	IN
cord-006229-7yoilsho	3732	17	a	a	DT
cord-006229-7yoilsho	3732	18	dose	dose	NN
cord-006229-7yoilsho	3732	19	-	-	HYPH
cord-006229-7yoilsho	3732	20	dependent	dependent	JJ
cord-006229-7yoilsho	3732	21	manner	manner	NN
cord-006229-7yoilsho	3732	22	in	in	IN
cord-006229-7yoilsho	3732	23	CaCO-2	CaCO-2	NNP
cord-006229-7yoilsho	3732	24	and	and	CC
cord-006229-7yoilsho	3732	25	HCT116-cells	HCT116-cells	NNP
cord-006229-7yoilsho	3732	26	as	as	IN
cord-006229-7yoilsho	3732	27	shown	show	VBN
cord-006229-7yoilsho	3732	28	by	by	IN
cord-006229-7yoilsho	3732	29	flow	flow	NN
cord-006229-7yoilsho	3732	30	cytometry	cytometry	NN
cord-006229-7yoilsho	3732	31	.	.	.
cord-006229-7yoilsho	3733	1	Consistent	consistent	JJ
cord-006229-7yoilsho	3733	2	with	with	IN
cord-006229-7yoilsho	3733	3	this	this	DT
cord-006229-7yoilsho	3733	4	finding	finding	NN
cord-006229-7yoilsho	3733	5	,	,	,
cord-006229-7yoilsho	3733	6	hemin	hemin	NNP
cord-006229-7yoilsho	3733	7	dose	dose	RB
cord-006229-7yoilsho	3733	8	-	-	:
cord-006229-7yoilsho	3733	9	dependently	dependently	RB
cord-006229-7yoilsho	3733	10	induced	induce	VBN
cord-006229-7yoilsho	3733	11	the	the	DT
cord-006229-7yoilsho	3733	12	oxidative	oxidative	JJ
cord-006229-7yoilsho	3733	13	DNA	dna	NN
cord-006229-7yoilsho	3733	14	lesion	lesion	NN
cord-006229-7yoilsho	3733	15	8-oxoguanine	8-oxoguanine	CD
cord-006229-7yoilsho	3733	16	(	(	-LRB-
cord-006229-7yoilsho	3733	17	8-oxoG	8-oxog	CD
cord-006229-7yoilsho	3733	18	)	)	-RRB-
cord-006229-7yoilsho	3733	19	as	as	IN
cord-006229-7yoilsho	3733	20	revealed	reveal	VBN
cord-006229-7yoilsho	3733	21	by	by	IN
cord-006229-7yoilsho	3733	22	slot	slot	NN
cord-006229-7yoilsho	3733	23	blot	blot	NN
cord-006229-7yoilsho	3733	24	analysis	analysis	NN
cord-006229-7yoilsho	3733	25	and	and	CC
cord-006229-7yoilsho	3733	26	Fpg	fpg	NN
cord-006229-7yoilsho	3733	27	-	-	HYPH
cord-006229-7yoilsho	3733	28	modified	modify	VBN
cord-006229-7yoilsho	3733	29	alkaline	alkaline	JJ
cord-006229-7yoilsho	3733	30	Comet	Comet	NNP
cord-006229-7yoilsho	3733	31	assay	assay	NN
cord-006229-7yoilsho	3733	32	.	.	.
cord-006229-7yoilsho	3734	1	Using	use	VBG
cord-006229-7yoilsho	3734	2	a	a	DT
cord-006229-7yoilsho	3734	3	pharmacological	pharmacological	JJ
cord-006229-7yoilsho	3734	4	inhibitor	inhibitor	NN
cord-006229-7yoilsho	3734	5	of	of	IN
cord-006229-7yoilsho	3734	6	MutT	MutT	NNP
cord-006229-7yoilsho	3734	7	homologue	homologue	NN
cord-006229-7yoilsho	3734	8	1	1	CD
cord-006229-7yoilsho	3734	9	(	(	-LRB-
cord-006229-7yoilsho	3734	10	MTH1	MTH1	NNP
cord-006229-7yoilsho	3734	11	)	)	-RRB-
cord-006229-7yoilsho	3734	12	,	,	,
cord-006229-7yoilsho	3734	13	which	which	WDT
cord-006229-7yoilsho	3734	14	protects	protect	VBZ
cord-006229-7yoilsho	3734	15	the	the	DT
cord-006229-7yoilsho	3734	16	nucleotide	nucleotide	JJ
cord-006229-7yoilsho	3734	17	pool	pool	NN
cord-006229-7yoilsho	3734	18	by	by	IN
cord-006229-7yoilsho	3734	19	hydrolysis	hydrolysis	NN
cord-006229-7yoilsho	3734	20	of	of	IN
cord-006229-7yoilsho	3734	21	8-oxoGTP	8-oxogtp	CD
cord-006229-7yoilsho	3734	22	,	,	,
cord-006229-7yoilsho	3734	23	8-oxoG	8-oxog	CD
cord-006229-7yoilsho	3734	24	DNA	dna	NN
cord-006229-7yoilsho	3734	25	adduct	adduct	NN
cord-006229-7yoilsho	3734	26	levels	level	NNS
cord-006229-7yoilsho	3734	27	in	in	IN
cord-006229-7yoilsho	3734	28	hemin	hemin	NN
cord-006229-7yoilsho	3734	29	-	-	HYPH
cord-006229-7yoilsho	3734	30	treated	treat	VBN
cord-006229-7yoilsho	3734	31	cells	cell	NNS
cord-006229-7yoilsho	3734	32	were	be	VBD
cord-006229-7yoilsho	3734	33	further	further	RB
cord-006229-7yoilsho	3734	34	enhanced	enhance	VBN
cord-006229-7yoilsho	3734	35	.	.	.
cord-006229-7yoilsho	3735	1	In	in	IN
cord-006229-7yoilsho	3735	2	contrast	contrast	NN
cord-006229-7yoilsho	3735	3	,	,	,
cord-006229-7yoilsho	3735	4	inorganic	inorganic	JJ
cord-006229-7yoilsho	3735	5	iron	iron	NN
cord-006229-7yoilsho	3735	6	hardly	hardly	RB
cord-006229-7yoilsho	3735	7	affected	affect	VBD
cord-006229-7yoilsho	3735	8	the	the	DT
cord-006229-7yoilsho	3735	9	cellular	cellular	JJ
cord-006229-7yoilsho	3735	10	ROS	ROS	NNP
cord-006229-7yoilsho	3735	11	level	level	NN
cord-006229-7yoilsho	3735	12	and	and	CC
cord-006229-7yoilsho	3735	13	only	only	RB
cord-006229-7yoilsho	3735	14	slightly	slightly	RB
cord-006229-7yoilsho	3735	15	increased	increased	JJ
cord-006229-7yoilsho	3735	16	oxidative	oxidative	JJ
cord-006229-7yoilsho	3735	17	DNA	dna	NN
cord-006229-7yoilsho	3735	18	damage	damage	NN
cord-006229-7yoilsho	3735	19	.	.	.
cord-006229-7yoilsho	3736	1	Subsequently	subsequently	RB
cord-006229-7yoilsho	3736	2	,	,	,
cord-006229-7yoilsho	3736	3	a	a	DT
cord-006229-7yoilsho	3736	4	time	time	NN
cord-006229-7yoilsho	3736	5	-	-	HYPH
cord-006229-7yoilsho	3736	6	and	and	CC
cord-006229-7yoilsho	3736	7	dose	dose	NN
cord-006229-7yoilsho	3736	8	-	-	HYPH
cord-006229-7yoilsho	3736	9	dependent	dependent	JJ
cord-006229-7yoilsho	3736	10	activation	activation	NN
cord-006229-7yoilsho	3736	11	of	of	IN
cord-006229-7yoilsho	3736	12	the	the	DT
cord-006229-7yoilsho	3736	13	DNA	dna	NN
cord-006229-7yoilsho	3736	14	damage	damage	NN
cord-006229-7yoilsho	3736	15	response	response	NN
cord-006229-7yoilsho	3736	16	(	(	-LRB-
cord-006229-7yoilsho	3736	17	DDR	DDR	NNP
cord-006229-7yoilsho	3736	18	)	)	-RRB-
cord-006229-7yoilsho	3736	19	by	by	IN
cord-006229-7yoilsho	3736	20	hemin	hemin	NNP
cord-006229-7yoilsho	3736	21	was	be	VBD
cord-006229-7yoilsho	3736	22	shown	show	VBN
cord-006229-7yoilsho	3736	23	in	in	IN
cord-006229-7yoilsho	3736	24	HCT116	HCT116	NNP
cord-006229-7yoilsho	3736	25	and	and	CC
cord-006229-7yoilsho	3736	26	CaCO-2	CaCO-2	NNP
cord-006229-7yoilsho	3736	27	cells	cell	NNS
cord-006229-7yoilsho	3736	28	using	use	VBG
cord-006229-7yoilsho	3736	29	western	western	JJ
cord-006229-7yoilsho	3736	30	blot	blot	NN
cord-006229-7yoilsho	3736	31	analysis	analysis	NN
cord-006229-7yoilsho	3736	32	,	,	,
cord-006229-7yoilsho	3736	33	which	which	WDT
cord-006229-7yoilsho	3736	34	was	be	VBD
cord-006229-7yoilsho	3736	35	followed	follow	VBN
cord-006229-7yoilsho	3736	36	by	by	IN
cord-006229-7yoilsho	3736	37	a	a	DT
cord-006229-7yoilsho	3736	38	reduction	reduction	NN
cord-006229-7yoilsho	3736	39	in	in	IN
cord-006229-7yoilsho	3736	40	cell	cell	NN
cord-006229-7yoilsho	3736	41	viability	viability	NN
cord-006229-7yoilsho	3736	42	at	at	IN
cord-006229-7yoilsho	3736	43	high	high	JJ
cord-006229-7yoilsho	3736	44	doses	dose	NNS
cord-006229-7yoilsho	3736	45	after	after	IN
cord-006229-7yoilsho	3736	46	72	72	CD
cord-006229-7yoilsho	3736	47	h.	h.	NN
cord-006229-7yoilsho	3736	48	Finally	finally	RB
cord-006229-7yoilsho	3736	49	,	,	,
cord-006229-7yoilsho	3736	50	the	the	DT
cord-006229-7yoilsho	3736	51	cytotoxic	cytotoxic	JJ
cord-006229-7yoilsho	3736	52	effects	effect	NNS
cord-006229-7yoilsho	3736	53	of	of	IN
cord-006229-7yoilsho	3736	54	hemin	hemin	NN
cord-006229-7yoilsho	3736	55	and	and	CC
cord-006229-7yoilsho	3736	56	inorganic	inorganic	JJ
cord-006229-7yoilsho	3736	57	iron	iron	NN
cord-006229-7yoilsho	3736	58	were	be	VBD
cord-006229-7yoilsho	3736	59	tested	test	VBN
cord-006229-7yoilsho	3736	60	using	use	VBG
cord-006229-7yoilsho	3736	61	an	an	DT
cord-006229-7yoilsho	3736	62	ex	ex	FW
cord-006229-7yoilsho	3736	63	vivo	vivo	NN
cord-006229-7yoilsho	3736	64	model	model	NN
cord-006229-7yoilsho	3736	65	of	of	IN
cord-006229-7yoilsho	3736	66	intestinal	intestinal	JJ
cord-006229-7yoilsho	3736	67	crypt	crypt	NN
cord-006229-7yoilsho	3736	68	organoids	organoid	NNS
cord-006229-7yoilsho	3736	69	.	.	.
cord-006229-7yoilsho	3737	1	Preliminary	preliminary	JJ
cord-006229-7yoilsho	3737	2	results	result	NNS
cord-006229-7yoilsho	3737	3	indicate	indicate	VBP
cord-006229-7yoilsho	3737	4	that	that	IN
cord-006229-7yoilsho	3737	5	hemin	hemin	NN
cord-006229-7yoilsho	3737	6	is	be	VBZ
cord-006229-7yoilsho	3737	7	highly	highly	RB
cord-006229-7yoilsho	3737	8	cytotoxic	cytotoxic	JJ
cord-006229-7yoilsho	3737	9	in	in	IN
cord-006229-7yoilsho	3737	10	organoids	organoid	NNS
cord-006229-7yoilsho	3737	11	,	,	,
cord-006229-7yoilsho	3737	12	whereas	whereas	IN
cord-006229-7yoilsho	3737	13	inorganic	inorganic	JJ
cord-006229-7yoilsho	3737	14	iron	iron	NN
cord-006229-7yoilsho	3737	15	does	do	VBZ
cord-006229-7yoilsho	3737	16	not	not	RB
cord-006229-7yoilsho	3737	17	impair	impair	VB
cord-006229-7yoilsho	3737	18	their	-PRON-	PRP$
cord-006229-7yoilsho	3737	19	viability	viability	NN
cord-006229-7yoilsho	3737	20	.	.	.
cord-006229-7yoilsho	3738	1	Taken	take	VBN
cord-006229-7yoilsho	3738	2	together	together	RB
cord-006229-7yoilsho	3738	3	,	,	,
cord-006229-7yoilsho	3738	4	this	this	DT
cord-006229-7yoilsho	3738	5	study	study	NN
cord-006229-7yoilsho	3738	6	demonstrated	demonstrate	VBD
cord-006229-7yoilsho	3738	7	that	that	IN
cord-006229-7yoilsho	3738	8	hemin	hemin	NNP
cord-006229-7yoilsho	3738	9	induces	induce	VBZ
cord-006229-7yoilsho	3738	10	oxidative	oxidative	JJ
cord-006229-7yoilsho	3738	11	stress	stress	NN
cord-006229-7yoilsho	3738	12	and	and	CC
cord-006229-7yoilsho	3738	13	DNA	dna	NN
cord-006229-7yoilsho	3738	14	damage	damage	NN
cord-006229-7yoilsho	3738	15	,	,	,
cord-006229-7yoilsho	3738	16	resulting	result	VBG
cord-006229-7yoilsho	3738	17	in	in	IN
cord-006229-7yoilsho	3738	18	the	the	DT
cord-006229-7yoilsho	3738	19	activation	activation	NN
cord-006229-7yoilsho	3738	20	of	of	IN
cord-006229-7yoilsho	3738	21	the	the	DT
cord-006229-7yoilsho	3738	22	DDR	ddr	NN
cord-006229-7yoilsho	3738	23	and	and	CC
cord-006229-7yoilsho	3738	24	subsequent	subsequent	JJ
cord-006229-7yoilsho	3738	25	cytotoxicity	cytotoxicity	NN
cord-006229-7yoilsho	3738	26	.	.	.
cord-006229-7yoilsho	3739	1	In	in	IN
cord-006229-7yoilsho	3739	2	contrast	contrast	NN
cord-006229-7yoilsho	3739	3	,	,	,
cord-006229-7yoilsho	3739	4	inorganic	inorganic	JJ
cord-006229-7yoilsho	3739	5	iron	iron	NN
cord-006229-7yoilsho	3739	6	displayed	display	VBD
cord-006229-7yoilsho	3739	7	only	only	RB
cord-006229-7yoilsho	3739	8	modest	modest	JJ
cord-006229-7yoilsho	3739	9	effects	effect	NNS
cord-006229-7yoilsho	3739	10	.	.	.
cord-006229-7yoilsho	3740	1	Further	further	RB
cord-006229-7yoilsho	3740	2	in	in	IN
cord-006229-7yoilsho	3740	3	vivo	vivo	NN
cord-006229-7yoilsho	3740	4	studies	study	NNS
cord-006229-7yoilsho	3740	5	using	use	VBG
cord-006229-7yoilsho	3740	6	DNA	dna	NN
cord-006229-7yoilsho	3740	7	-	-	HYPH
cord-006229-7yoilsho	3740	8	repair	repair	NN
cord-006229-7yoilsho	3740	9	deficient	deficient	JJ
cord-006229-7yoilsho	3740	10	and	and	CC
cord-006229-7yoilsho	3740	11	proficient	proficient	JJ
cord-006229-7yoilsho	3740	12	animals	animal	NNS
cord-006229-7yoilsho	3740	13	will	will	MD
cord-006229-7yoilsho	3740	14	shed	shed	VB
cord-006229-7yoilsho	3740	15	light	light	NN
cord-006229-7yoilsho	3740	16	on	on	IN
cord-006229-7yoilsho	3740	17	the	the	DT
cord-006229-7yoilsho	3740	18	contribution	contribution	NN
cord-006229-7yoilsho	3740	19	of	of	IN
cord-006229-7yoilsho	3740	20	specific	specific	JJ
cord-006229-7yoilsho	3740	21	DNA	dna	NN
cord-006229-7yoilsho	3740	22	lesions	lesion	NNS
cord-006229-7yoilsho	3740	23	to	to	IN
cord-006229-7yoilsho	3740	24	hemeassociated	hemeassociated	JJ
cord-006229-7yoilsho	3740	25	colorectal	colorectal	JJ
cord-006229-7yoilsho	3740	26	carcinogenesis	carcinogenesis	NN
cord-006229-7yoilsho	3740	27	.	.	.
cord-006229-7yoilsho	3741	1	Red	red	JJ
cord-006229-7yoilsho	3741	2	and	and	CC
cord-006229-7yoilsho	3741	3	processed	process	VBD
cord-006229-7yoilsho	3741	4	meat	meat	NN
cord-006229-7yoilsho	3741	5	consumption	consumption	NN
cord-006229-7yoilsho	3741	6	is	be	VBZ
cord-006229-7yoilsho	3741	7	known	know	VBN
cord-006229-7yoilsho	3741	8	to	to	TO
cord-006229-7yoilsho	3741	9	be	be	VB
cord-006229-7yoilsho	3741	10	a	a	DT
cord-006229-7yoilsho	3741	11	crucial	crucial	JJ
cord-006229-7yoilsho	3741	12	risk	risk	NN
cord-006229-7yoilsho	3741	13	factor	factor	NN
cord-006229-7yoilsho	3741	14	in	in	IN
cord-006229-7yoilsho	3741	15	the	the	DT
cord-006229-7yoilsho	3741	16	development	development	NN
cord-006229-7yoilsho	3741	17	of	of	IN
cord-006229-7yoilsho	3741	18	colon	colon	NN
cord-006229-7yoilsho	3741	19	cancer	cancer	NN
cord-006229-7yoilsho	3741	20	,	,	,
cord-006229-7yoilsho	3741	21	which	which	WDT
cord-006229-7yoilsho	3741	22	is	be	VBZ
cord-006229-7yoilsho	3741	23	one	one	CD
cord-006229-7yoilsho	3741	24	of	of	IN
cord-006229-7yoilsho	3741	25	the	the	DT
cord-006229-7yoilsho	3741	26	most	most	RBS
cord-006229-7yoilsho	3741	27	common	common	JJ
cord-006229-7yoilsho	3741	28	cancers	cancer	NNS
cord-006229-7yoilsho	3741	29	worldwide	worldwide	RB
cord-006229-7yoilsho	3741	30	.	.	.
cord-006229-7yoilsho	3742	1	A	a	DT
cord-006229-7yoilsho	3742	2	diet	diet	NN
cord-006229-7yoilsho	3742	3	rich	rich	JJ
cord-006229-7yoilsho	3742	4	in	in	IN
cord-006229-7yoilsho	3742	5	red	red	JJ
cord-006229-7yoilsho	3742	6	and	and	CC
cord-006229-7yoilsho	3742	7	processed	process	VBN
cord-006229-7yoilsho	3742	8	meat	meat	NN
cord-006229-7yoilsho	3742	9	increases	increase	NNS
cord-006229-7yoilsho	3742	10	N	n	CD
cord-006229-7yoilsho	3742	11	-	-	HYPH
cord-006229-7yoilsho	3742	12	nitrosation	nitrosation	NN
cord-006229-7yoilsho	3742	13	within	within	IN
cord-006229-7yoilsho	3742	14	the	the	DT
cord-006229-7yoilsho	3742	15	colon	colon	NN
cord-006229-7yoilsho	3742	16	leading	lead	VBG
cord-006229-7yoilsho	3742	17	to	to	IN
cord-006229-7yoilsho	3742	18	an	an	DT
cord-006229-7yoilsho	3742	19	increase	increase	NN
cord-006229-7yoilsho	3742	20	in	in	IN
cord-006229-7yoilsho	3742	21	endogenously	endogenously	RB
cord-006229-7yoilsho	3742	22	formed	form	VBN
cord-006229-7yoilsho	3742	23	nitroso	nitroso	NNP
cord-006229-7yoilsho	3742	24	compounds	compound	NNS
cord-006229-7yoilsho	3742	25	.	.	.
cord-006229-7yoilsho	3743	1	These	these	DT
cord-006229-7yoilsho	3743	2	compounds	compound	NNS
cord-006229-7yoilsho	3743	3	are	be	VBP
cord-006229-7yoilsho	3743	4	able	able	JJ
cord-006229-7yoilsho	3743	5	to	to	TO
cord-006229-7yoilsho	3743	6	alkylate	alkylate	VB
cord-006229-7yoilsho	3743	7	DNA	DNA	NNP
cord-006229-7yoilsho	3743	8	of	of	IN
cord-006229-7yoilsho	3743	9	gastrointestinal	gastrointestinal	JJ
cord-006229-7yoilsho	3743	10	tract	tract	NN
cord-006229-7yoilsho	3743	11	cells	cell	NNS
cord-006229-7yoilsho	3743	12	,	,	,
cord-006229-7yoilsho	3743	13	resulting	result	VBG
cord-006229-7yoilsho	3743	14	in	in	IN
cord-006229-7yoilsho	3743	15	the	the	DT
cord-006229-7yoilsho	3743	16	formation	formation	NN
cord-006229-7yoilsho	3743	17	of	of	IN
cord-006229-7yoilsho	3743	18	DNA	dna	NN
cord-006229-7yoilsho	3743	19	adducts	adduct	NNS
cord-006229-7yoilsho	3743	20	such	such	JJ
cord-006229-7yoilsho	3743	21	as	as	IN
cord-006229-7yoilsho	3743	22	-MeG	-meg	ADD
cord-006229-7yoilsho	3743	23	is	be	VBZ
cord-006229-7yoilsho	3743	24	repaired	repair	VBN
cord-006229-7yoilsho	3743	25	by	by	IN
cord-006229-7yoilsho	3743	26	MGMT	MGMT	NNP
cord-006229-7yoilsho	3743	27	,	,	,
cord-006229-7yoilsho	3743	28	the	the	DT
cord-006229-7yoilsho	3743	29	potential	potential	NN
cord-006229-7yoilsho	3743	30	of	of	IN
cord-006229-7yoilsho	3743	31	this	this	DT
cord-006229-7yoilsho	3743	32	enzyme	enzyme	NN
cord-006229-7yoilsho	3743	33	to	to	TO
cord-006229-7yoilsho	3743	34	repair	repair	VB
cord-006229-7yoilsho	3743	35	O	o	UH
cord-006229-7yoilsho	3743	36	6	6	CD
cord-006229-7yoilsho	3743	37	-CMG	-CMG	-RRB-
cord-006229-7yoilsho	3743	38	in	in	IN
cord-006229-7yoilsho	3743	39	cells	cell	NNS
cord-006229-7yoilsho	3743	40	is	be	VBZ
cord-006229-7yoilsho	3743	41	not	not	RB
cord-006229-7yoilsho	3743	42	well	well	RB
cord-006229-7yoilsho	3743	43	characterized	characterize	VBN
cord-006229-7yoilsho	3743	44	.	.	.
cord-006229-7yoilsho	3744	1	Additionally	additionally	RB
cord-006229-7yoilsho	3744	2	,	,	,
cord-006229-7yoilsho	3744	3	adenomas	adenoma	NNS
cord-006229-7yoilsho	3744	4	containing	contain	VBG
cord-006229-7yoilsho	3744	5	a	a	DT
cord-006229-7yoilsho	3744	6	K	K	NNP
cord-006229-7yoilsho	3744	7	-	-	HYPH
cord-006229-7yoilsho	3744	8	ras	ras	NNP
cord-006229-7yoilsho	3744	9	GC	GC	NNP
cord-006229-7yoilsho	3744	10	-	-	HYPH
cord-006229-7yoilsho	3744	11	AT	AT	NNP
cord-006229-7yoilsho	3744	12	transition	transition	NN
cord-006229-7yoilsho	3744	13	mutation	mutation	NN
cord-006229-7yoilsho	3744	14	have	have	VBP
cord-006229-7yoilsho	3744	15	lower	low	JJR
cord-006229-7yoilsho	3744	16	MGMT	MGMT	NNS
cord-006229-7yoilsho	3744	17	levels	level	NNS
cord-006229-7yoilsho	3744	18	than	than	IN
cord-006229-7yoilsho	3744	19	adenomas	adenoma	NNS
cord-006229-7yoilsho	3744	20	without	without	IN
cord-006229-7yoilsho	3744	21	this	this	DT
cord-006229-7yoilsho	3744	22	mutation	mutation	NN
cord-006229-7yoilsho	3744	23	.	.	.
cord-006229-7yoilsho	3745	1	Therefore	therefore	RB
cord-006229-7yoilsho	3745	2	,	,	,
cord-006229-7yoilsho	3745	3	the	the	DT
cord-006229-7yoilsho	3745	4	aim	aim	NN
cord-006229-7yoilsho	3745	5	of	of	IN
cord-006229-7yoilsho	3745	6	this	this	DT
cord-006229-7yoilsho	3745	7	study	study	NN
cord-006229-7yoilsho	3745	8	is	be	VBZ
cord-006229-7yoilsho	3745	9	to	to	TO
cord-006229-7yoilsho	3745	10	determine	determine	VB
cord-006229-7yoilsho	3745	11	the	the	DT
cord-006229-7yoilsho	3745	12	role	role	NN
cord-006229-7yoilsho	3745	13	of	of	IN
cord-006229-7yoilsho	3745	14	MGMT	MGMT	NNP
cord-006229-7yoilsho	3745	15	in	in	IN
cord-006229-7yoilsho	3745	16	protecting	protect	VBG
cord-006229-7yoilsho	3745	17	colorectal	colorectal	JJ
cord-006229-7yoilsho	3745	18	cells	cell	NNS
cord-006229-7yoilsho	3745	19	from	from	IN
cord-006229-7yoilsho	3745	20	genotoxicity	genotoxicity	NN
cord-006229-7yoilsho	3745	21	by	by	IN
cord-006229-7yoilsho	3745	22	repairing	repair	VBG
cord-006229-7yoilsho	3745	23	O	O	NNP
cord-006229-7yoilsho	3745	24	6	6	CD
cord-006229-7yoilsho	3745	25	-CMG	-CMG	NNS
cord-006229-7yoilsho	3745	26	adducts	adduct	NNS
cord-006229-7yoilsho	3745	27	.	.	.
cord-006229-7yoilsho	3746	1	For	for	IN
cord-006229-7yoilsho	3746	2	this	this	DT
cord-006229-7yoilsho	3746	3	purpose	purpose	NN
cord-006229-7yoilsho	3746	4	,	,	,
cord-006229-7yoilsho	3746	5	an	an	DT
cord-006229-7yoilsho	3746	6	MGMT	mgmt	NN
cord-006229-7yoilsho	3746	7	-	-	HYPH
cord-006229-7yoilsho	3746	8	deficient	deficient	JJ
cord-006229-7yoilsho	3746	9	non	non	JJ
cord-006229-7yoilsho	3746	10	-	-	JJ
cord-006229-7yoilsho	3746	11	transformed	transformed	JJ
cord-006229-7yoilsho	3746	12	human	human	JJ
cord-006229-7yoilsho	3746	13	colon	colon	NN
cord-006229-7yoilsho	3746	14	epithelial	epithelial	JJ
cord-006229-7yoilsho	3746	15	cell	cell	NN
cord-006229-7yoilsho	3746	16	line	line	NN
cord-006229-7yoilsho	3746	17	was	be	VBD
cord-006229-7yoilsho	3746	18	established	establish	VBN
cord-006229-7yoilsho	3746	19	by	by	IN
cord-006229-7yoilsho	3746	20	stable	stable	JJ
cord-006229-7yoilsho	3746	21	transfection	transfection	NN
cord-006229-7yoilsho	3746	22	via	via	IN
cord-006229-7yoilsho	3746	23	RNA	RNA	NNP
cord-006229-7yoilsho	3746	24	interference	interference	NN
cord-006229-7yoilsho	3746	25	to	to	TO
cord-006229-7yoilsho	3746	26	inhibit	inhibit	VB
cord-006229-7yoilsho	3746	27	the	the	DT
cord-006229-7yoilsho	3746	28	expression	expression	NN
cord-006229-7yoilsho	3746	29	and	and	CC
cord-006229-7yoilsho	3746	30	therefore	therefore	RB
cord-006229-7yoilsho	3746	31	the	the	DT
cord-006229-7yoilsho	3746	32	activity	activity	NN
cord-006229-7yoilsho	3746	33	of	of	IN
cord-006229-7yoilsho	3746	34	MGMT	MGMT	NNP
cord-006229-7yoilsho	3746	35	.	.	.
cord-006229-7yoilsho	3747	1	The	the	DT
cord-006229-7yoilsho	3747	2	transfected	transfected	JJ
cord-006229-7yoilsho	3747	3	cell	cell	NN
cord-006229-7yoilsho	3747	4	line	line	NN
cord-006229-7yoilsho	3747	5	was	be	VBD
cord-006229-7yoilsho	3747	6	analyzed	analyze	VBN
cord-006229-7yoilsho	3747	7	for	for	IN
cord-006229-7yoilsho	3747	8	complete	complete	JJ
cord-006229-7yoilsho	3747	9	MGMT	MGMT	NNP
cord-006229-7yoilsho	3747	10	gene	gene	NN
cord-006229-7yoilsho	3747	11	silencing	silencing	NN
cord-006229-7yoilsho	3747	12	by	by	IN
cord-006229-7yoilsho	3747	13	activity	activity	NN
cord-006229-7yoilsho	3747	14	and	and	CC
cord-006229-7yoilsho	3747	15	expression	expression	NN
cord-006229-7yoilsho	3747	16	analyses	analysis	NNS
cord-006229-7yoilsho	3747	17	and	and	CC
cord-006229-7yoilsho	3747	18	cell	cell	NN
cord-006229-7yoilsho	3747	19	characterization	characterization	NN
cord-006229-7yoilsho	3747	20	.	.	.
cord-006229-7yoilsho	3748	1	Results	result	NNS
cord-006229-7yoilsho	3748	2	confirmed	confirm	VBD
cord-006229-7yoilsho	3748	3	that	that	IN
cord-006229-7yoilsho	3748	4	there	there	EX
cord-006229-7yoilsho	3748	5	was	be	VBD
cord-006229-7yoilsho	3748	6	neither	neither	DT
cord-006229-7yoilsho	3748	7	expression	expression	NN
cord-006229-7yoilsho	3748	8	nor	nor	CC
cord-006229-7yoilsho	3748	9	activity	activity	NN
cord-006229-7yoilsho	3748	10	for	for	IN
cord-006229-7yoilsho	3748	11	MGMT	MGMT	NNS
cord-006229-7yoilsho	3748	12	in	in	IN
cord-006229-7yoilsho	3748	13	the	the	DT
cord-006229-7yoilsho	3748	14	transfected	transfecte	VBN
cord-006229-7yoilsho	3748	15	cells	cell	NNS
cord-006229-7yoilsho	3748	16	,	,	,
cord-006229-7yoilsho	3748	17	and	and	CC
cord-006229-7yoilsho	3748	18	the	the	DT
cord-006229-7yoilsho	3748	19	cell	cell	NN
cord-006229-7yoilsho	3748	20	characterization	characterization	NN
cord-006229-7yoilsho	3748	21	data	datum	NNS
cord-006229-7yoilsho	3748	22	showed	show	VBD
cord-006229-7yoilsho	3748	23	that	that	IN
cord-006229-7yoilsho	3748	24	MGMT	MGMT	NNP
cord-006229-7yoilsho	3748	25	deficiency	deficiency	NN
cord-006229-7yoilsho	3748	26	did	do	VBD
cord-006229-7yoilsho	3748	27	not	not	RB
cord-006229-7yoilsho	3748	28	lead	lead	VB
cord-006229-7yoilsho	3748	29	to	to	IN
cord-006229-7yoilsho	3748	30	differences	difference	NNS
cord-006229-7yoilsho	3748	31	in	in	IN
cord-006229-7yoilsho	3748	32	growth	growth	NN
cord-006229-7yoilsho	3748	33	behavior	behavior	NN
cord-006229-7yoilsho	3748	34	or	or	CC
cord-006229-7yoilsho	3748	35	cell	cell	NN
cord-006229-7yoilsho	3748	36	morphology	morphology	NN
cord-006229-7yoilsho	3748	37	or	or	CC
cord-006229-7yoilsho	3748	38	malignant	malignant	JJ
cord-006229-7yoilsho	3748	39	cell	cell	NN
cord-006229-7yoilsho	3748	40	transformation	transformation	NN
cord-006229-7yoilsho	3748	41	.	.	.
cord-006229-7yoilsho	3749	1	Cytotoxicity	cytotoxicity	NN
cord-006229-7yoilsho	3749	2	experiments	experiment	NNS
cord-006229-7yoilsho	3749	3	performed	perform	VBN
cord-006229-7yoilsho	3749	4	in	in	IN
cord-006229-7yoilsho	3749	5	the	the	DT
cord-006229-7yoilsho	3749	6	transfected	transfected	JJ
cord-006229-7yoilsho	3749	7	and	and	CC
cord-006229-7yoilsho	3749	8	nontransfected	nontransfected	JJ
cord-006229-7yoilsho	3749	9	cell	cell	NN
cord-006229-7yoilsho	3749	10	lines	line	NNS
cord-006229-7yoilsho	3749	11	by	by	IN
cord-006229-7yoilsho	3749	12	treatment	treatment	NN
cord-006229-7yoilsho	3749	13	with	with	IN
cord-006229-7yoilsho	3749	14	DNA	dna	NN
cord-006229-7yoilsho	3749	15	alkylating	alkylating	JJ
cord-006229-7yoilsho	3749	16	agents	agent	NNS
cord-006229-7yoilsho	3749	17	suggest	suggest	VBP
cord-006229-7yoilsho	3749	18	that	that	IN
cord-006229-7yoilsho	3749	19	the	the	DT
cord-006229-7yoilsho	3749	20	MGMTdeficient	MGMTdeficient	NNP
cord-006229-7yoilsho	3749	21	cell	cell	NN
cord-006229-7yoilsho	3749	22	line	line	NN
cord-006229-7yoilsho	3749	23	is	be	VBZ
cord-006229-7yoilsho	3749	24	more	more	RBR
cord-006229-7yoilsho	3749	25	sensitive	sensitive	JJ
cord-006229-7yoilsho	3749	26	to	to	IN
cord-006229-7yoilsho	3749	27	DNA	dna	NN
cord-006229-7yoilsho	3749	28	alkylating	alkylating	JJ
cord-006229-7yoilsho	3749	29	agents	agent	NNS
cord-006229-7yoilsho	3749	30	than	than	IN
cord-006229-7yoilsho	3749	31	the	the	DT
cord-006229-7yoilsho	3749	32	non	non	JJ
cord-006229-7yoilsho	3749	33	-	-	JJ
cord-006229-7yoilsho	3749	34	transfected	transfected	JJ
cord-006229-7yoilsho	3749	35	cell	cell	NN
cord-006229-7yoilsho	3749	36	line	line	NN
cord-006229-7yoilsho	3749	37	.	.	.
cord-006229-7yoilsho	3750	1	These	these	DT
cord-006229-7yoilsho	3750	2	results	result	NNS
cord-006229-7yoilsho	3750	3	were	be	VBD
cord-006229-7yoilsho	3750	4	also	also	RB
cord-006229-7yoilsho	3750	5	supported	support	VBN
cord-006229-7yoilsho	3750	6	by	by	IN
cord-006229-7yoilsho	3750	7	DNA	dna	NN
cord-006229-7yoilsho	3750	8	damage	damage	NN
cord-006229-7yoilsho	3750	9	analysis	analysis	NN
cord-006229-7yoilsho	3750	10	via	via	IN
cord-006229-7yoilsho	3750	11	comet	comet	JJ
cord-006229-7yoilsho	3750	12	assay	assay	NN
cord-006229-7yoilsho	3750	13	.	.	.
cord-006229-7yoilsho	3751	1	Asarones	asarone	NNS
cord-006229-7yoilsho	3751	2	are	be	VBP
cord-006229-7yoilsho	3751	3	secondary	secondary	JJ
cord-006229-7yoilsho	3751	4	plant	plant	NN
cord-006229-7yoilsho	3751	5	constituents	constituent	NNS
cord-006229-7yoilsho	3751	6	mainly	mainly	RB
cord-006229-7yoilsho	3751	7	occurring	occur	VBG
cord-006229-7yoilsho	3751	8	in	in	IN
cord-006229-7yoilsho	3751	9	Acorus	Acorus	NNP
cord-006229-7yoilsho	3751	10	calamus	calamus	NN
cord-006229-7yoilsho	3751	11	L.	L.	NNP
cord-006229-7yoilsho	3751	12	and	and	CC
cord-006229-7yoilsho	3751	13	Guatteria	Guatteria	NNP
cord-006229-7yoilsho	3751	14	gaumeri	gaumeri	NNP
cord-006229-7yoilsho	3751	15	.	.	.
cord-006229-7yoilsho	3752	1	The	the	DT
cord-006229-7yoilsho	3752	2	essential	essential	JJ
cord-006229-7yoilsho	3752	3	oil	oil	NN
cord-006229-7yoilsho	3752	4	of	of	IN
cord-006229-7yoilsho	3752	5	the	the	DT
cord-006229-7yoilsho	3752	6	rhizome	rhizome	NN
cord-006229-7yoilsho	3752	7	of	of	IN
cord-006229-7yoilsho	3752	8	Acorus	Acorus	NNP
cord-006229-7yoilsho	3752	9	calamus	calamus	NN
cord-006229-7yoilsho	3752	10	L.	L.	NNP
cord-006229-7yoilsho	3752	11	is	be	VBZ
cord-006229-7yoilsho	3752	12	used	use	VBN
cord-006229-7yoilsho	3752	13	for	for	IN
cord-006229-7yoilsho	3752	14	flavoring	flavoring	NN
cord-006229-7yoilsho	3752	15	of	of	IN
cord-006229-7yoilsho	3752	16	food	food	NN
cord-006229-7yoilsho	3752	17	and	and	CC
cord-006229-7yoilsho	3752	18	alcoholic	alcoholic	JJ
cord-006229-7yoilsho	3752	19	beverages	beverage	NNS
cord-006229-7yoilsho	3752	20	.	.	.
cord-006229-7yoilsho	3753	1	The	the	DT
cord-006229-7yoilsho	3753	2	concentration	concentration	NN
cord-006229-7yoilsho	3753	3	of	of	IN
cord-006229-7yoilsho	3753	4	β	β	NN
cord-006229-7yoilsho	3753	5	-	-	HYPH
cord-006229-7yoilsho	3753	6	asarone	asarone	NNP
cord-006229-7yoilsho	3753	7	(	(	-LRB-
cord-006229-7yoilsho	3753	8	bA	bA	NNP
cord-006229-7yoilsho	3753	9	)	)	-RRB-
cord-006229-7yoilsho	3753	10	in	in	IN
cord-006229-7yoilsho	3753	11	these	these	DT
cord-006229-7yoilsho	3753	12	oils	oil	NNS
cord-006229-7yoilsho	3753	13	varies	vary	VBZ
cord-006229-7yoilsho	3753	14	between	between	IN
cord-006229-7yoilsho	3753	15	0.3	0.3	CD
cord-006229-7yoilsho	3753	16	%	%	NN
cord-006229-7yoilsho	3753	17	and	and	CC
cord-006229-7yoilsho	3753	18	95	95	CD
cord-006229-7yoilsho	3753	19	%	%	NN
cord-006229-7yoilsho	3753	20	.	.	.
cord-006229-7yoilsho	3754	1	The	the	DT
cord-006229-7yoilsho	3754	2	bark	bark	NN
cord-006229-7yoilsho	3754	3	of	of	IN
cord-006229-7yoilsho	3754	4	Guatteria	Guatteria	NNP
cord-006229-7yoilsho	3754	5	gaumeri	gaumeri	NNP
cord-006229-7yoilsho	3754	6	,	,	,
cord-006229-7yoilsho	3754	7	which	which	WDT
cord-006229-7yoilsho	3754	8	is	be	VBZ
cord-006229-7yoilsho	3754	9	rich	rich	JJ
cord-006229-7yoilsho	3754	10	in	in	IN
cord-006229-7yoilsho	3754	11	αasarone	αasarone	NNP
cord-006229-7yoilsho	3754	12	(	(	-LRB-
cord-006229-7yoilsho	3754	13	aA	aA	NNP
cord-006229-7yoilsho	3754	14	)	)	-RRB-
cord-006229-7yoilsho	3754	15	,	,	,
cord-006229-7yoilsho	3754	16	is	be	VBZ
cord-006229-7yoilsho	3754	17	used	use	VBN
cord-006229-7yoilsho	3754	18	as	as	IN
cord-006229-7yoilsho	3754	19	cholesterol	cholesterol	NN
cord-006229-7yoilsho	3754	20	-	-	HYPH
cord-006229-7yoilsho	3754	21	lowering	lower	VBG
cord-006229-7yoilsho	3754	22	drug	drug	NN
cord-006229-7yoilsho	3754	23	and	and	CC
cord-006229-7yoilsho	3754	24	to	to	TO
cord-006229-7yoilsho	3754	25	treat	treat	VB
cord-006229-7yoilsho	3754	26	gallstones	gallstone	NNS
cord-006229-7yoilsho	3754	27	in	in	IN
cord-006229-7yoilsho	3754	28	traditional	traditional	JJ
cord-006229-7yoilsho	3754	29	Mexican	mexican	JJ
cord-006229-7yoilsho	3754	30	medicine	medicine	NN
cord-006229-7yoilsho	3754	31	.	.	.
cord-006229-7yoilsho	3755	1	Both	both	RB
cord-006229-7yoilsho	3755	2	,	,	,
cord-006229-7yoilsho	3755	3	aA	aA	NNP
cord-006229-7yoilsho	3755	4	and	and	CC
cord-006229-7yoilsho	3755	5	bA	bA	NNP
cord-006229-7yoilsho	3755	6	are	be	VBP
cord-006229-7yoilsho	3755	7	carcinogenic	carcinogenic	JJ
cord-006229-7yoilsho	3755	8	in	in	IN
cord-006229-7yoilsho	3755	9	rodents	rodent	NNS
cord-006229-7yoilsho	3755	10	and	and	CC
cord-006229-7yoilsho	3755	11	mutagenic	mutagenic	JJ
cord-006229-7yoilsho	3755	12	in	in	IN
cord-006229-7yoilsho	3755	13	the	the	DT
cord-006229-7yoilsho	3755	14	Ames	Ames	NNP
cord-006229-7yoilsho	3755	15	test	test	NN
cord-006229-7yoilsho	3755	16	after	after	IN
cord-006229-7yoilsho	3755	17	metabolic	metabolic	JJ
cord-006229-7yoilsho	3755	18	activation	activation	NN
cord-006229-7yoilsho	3755	19	and	and	CC
cord-006229-7yoilsho	3755	20	thus	thus	RB
cord-006229-7yoilsho	3755	21	classified	classify	VBN
cord-006229-7yoilsho	3755	22	as	as	IN
cord-006229-7yoilsho	3755	23	genotoxic	genotoxic	JJ
cord-006229-7yoilsho	3755	24	carcinogens	carcinogen	NNS
cord-006229-7yoilsho	3755	25	.	.	.
cord-006229-7yoilsho	3756	1	[	[	-LRB-
cord-006229-7yoilsho	3756	2	1	1	CD
cord-006229-7yoilsho	3756	3	,	,	,
cord-006229-7yoilsho	3756	4	2	2	CD
cord-006229-7yoilsho	3756	5	]	]	-RRB-
cord-006229-7yoilsho	3756	6	Previously	previously	RB
cord-006229-7yoilsho	3756	7	,	,	,
cord-006229-7yoilsho	3756	8	the	the	DT
cord-006229-7yoilsho	3756	9	major	major	JJ
cord-006229-7yoilsho	3756	10	metabolites	metabolite	NNS
cord-006229-7yoilsho	3756	11	in	in	IN
cord-006229-7yoilsho	3756	12	microsomal	microsomal	NNP
cord-006229-7yoilsho	3756	13	incubations	incubations	NNP
cord-006229-7yoilsho	3756	14	with	with	IN
cord-006229-7yoilsho	3756	15	aA	aA	NNP
cord-006229-7yoilsho	3756	16	and	and	CC
cord-006229-7yoilsho	3756	17	bA	bA	NNP
cord-006229-7yoilsho	3756	18	were	be	VBD
cord-006229-7yoilsho	3756	19	identified	identify	VBN
cord-006229-7yoilsho	3756	20	and	and	CC
cord-006229-7yoilsho	3756	21	synthesized	synthesize	VBN
cord-006229-7yoilsho	3756	22	in	in	IN
cord-006229-7yoilsho	3756	23	our	-PRON-	PRP$
cord-006229-7yoilsho	3756	24	laboratory	laboratory	NN
cord-006229-7yoilsho	3756	25	.	.	.
cord-006229-7yoilsho	3757	1	Side	side	NN
cord-006229-7yoilsho	3757	2	-	-	HYPH
cord-006229-7yoilsho	3757	3	chain	chain	NN
cord-006229-7yoilsho	3757	4	epoxides	epoxide	NNS
cord-006229-7yoilsho	3757	5	,	,	,
cord-006229-7yoilsho	3757	6	the	the	DT
cord-006229-7yoilsho	3757	7	corresponding	correspond	VBG
cord-006229-7yoilsho	3757	8	diols	diol	NNS
cord-006229-7yoilsho	3757	9	,	,	,
cord-006229-7yoilsho	3757	10	side	side	NN
cord-006229-7yoilsho	3757	11	-	-	HYPH
cord-006229-7yoilsho	3757	12	chain	chain	NN
cord-006229-7yoilsho	3757	13	alcohols	alcohol	NNS
cord-006229-7yoilsho	3757	14	and	and	CC
cord-006229-7yoilsho	3757	15	aldehydes	aldehyde	NNS
cord-006229-7yoilsho	3757	16	were	be	VBD
cord-006229-7yoilsho	3757	17	identified	identify	VBN
cord-006229-7yoilsho	3757	18	as	as	IN
cord-006229-7yoilsho	3757	19	the	the	DT
cord-006229-7yoilsho	3757	20	major	major	JJ
cord-006229-7yoilsho	3757	21	metabolites	metabolite	NNS
cord-006229-7yoilsho	3757	22	of	of	IN
cord-006229-7yoilsho	3757	23	aA	aA	NNP
cord-006229-7yoilsho	3757	24	and	and	CC
cord-006229-7yoilsho	3757	25	bA.	ba.	NN
cord-006229-7yoilsho	3757	26	[	[	-LRB-
cord-006229-7yoilsho	3757	27	3	3	CD
cord-006229-7yoilsho	3757	28	]	]	-RRB-
cord-006229-7yoilsho	3758	1	The	the	DT
cord-006229-7yoilsho	3758	2	investigation	investigation	NN
cord-006229-7yoilsho	3758	3	of	of	IN
cord-006229-7yoilsho	3758	4	the	the	DT
cord-006229-7yoilsho	3758	5	mutagenic	mutagenic	JJ
cord-006229-7yoilsho	3758	6	potency	potency	NN
cord-006229-7yoilsho	3758	7	in	in	IN
cord-006229-7yoilsho	3758	8	the	the	DT
cord-006229-7yoilsho	3758	9	Ames	Ames	NNP
cord-006229-7yoilsho	3758	10	fluctuation	fluctuation	NN
cord-006229-7yoilsho	3758	11	test	test	NN
cord-006229-7yoilsho	3758	12	showed	show	VBD
cord-006229-7yoilsho	3758	13	positive	positive	JJ
cord-006229-7yoilsho	3758	14	results	result	NNS
cord-006229-7yoilsho	3758	15	in	in	IN
cord-006229-7yoilsho	3758	16	the	the	DT
cord-006229-7yoilsho	3758	17	Salmonella	Salmonella	NNP
cord-006229-7yoilsho	3758	18	strain	strain	NN
cord-006229-7yoilsho	3758	19	TA	TA	NNP
cord-006229-7yoilsho	3758	20	100	100	CD
cord-006229-7yoilsho	3758	21	for	for	IN
cord-006229-7yoilsho	3758	22	aA	aA	NNP
cord-006229-7yoilsho	3758	23	and	and	CC
cord-006229-7yoilsho	3758	24	bA	bA	NNP
cord-006229-7yoilsho	3758	25	with	with	IN
cord-006229-7yoilsho	3758	26	metabolic	metabolic	JJ
cord-006229-7yoilsho	3758	27	activation	activation	NN
cord-006229-7yoilsho	3758	28	and	and	CC
cord-006229-7yoilsho	3758	29	for	for	IN
cord-006229-7yoilsho	3758	30	aA	aA	NNP
cord-006229-7yoilsho	3758	31	-	-	:
cord-006229-7yoilsho	3758	32	and	and	CC
cord-006229-7yoilsho	3758	33	bA	ba	NN
cord-006229-7yoilsho	3758	34	-	-	HYPH
cord-006229-7yoilsho	3758	35	epoxide	epoxide	NN
cord-006229-7yoilsho	3758	36	without	without	IN
cord-006229-7yoilsho	3758	37	metabolic	metabolic	JJ
cord-006229-7yoilsho	3758	38	activation	activation	NN
cord-006229-7yoilsho	3758	39	.	.	.
cord-006229-7yoilsho	3759	1	While	while	IN
cord-006229-7yoilsho	3759	2	it	-PRON-	PRP
cord-006229-7yoilsho	3759	3	is	be	VBZ
cord-006229-7yoilsho	3759	4	known	know	VBN
cord-006229-7yoilsho	3759	5	that	that	IN
cord-006229-7yoilsho	3759	6	epoxides	epoxide	NNS
cord-006229-7yoilsho	3759	7	are	be	VBP
cord-006229-7yoilsho	3759	8	reactive	reactive	JJ
cord-006229-7yoilsho	3759	9	against	against	IN
cord-006229-7yoilsho	3759	10	nucleophiles	nucleophile	NNS
cord-006229-7yoilsho	3759	11	we	-PRON-	PRP
cord-006229-7yoilsho	3759	12	set	set	VBP
cord-006229-7yoilsho	3759	13	up	up	RP
cord-006229-7yoilsho	3759	14	the	the	DT
cord-006229-7yoilsho	3759	15	hypothesis	hypothesis	NN
cord-006229-7yoilsho	3759	16	of	of	IN
cord-006229-7yoilsho	3759	17	DNA	dna	NN
cord-006229-7yoilsho	3759	18	-	-	HYPH
cord-006229-7yoilsho	3759	19	adduct	adduct	NN
cord-006229-7yoilsho	3759	20	formation	formation	NN
cord-006229-7yoilsho	3759	21	by	by	IN
cord-006229-7yoilsho	3759	22	epoxides	epoxide	NNS
cord-006229-7yoilsho	3759	23	to	to	TO
cord-006229-7yoilsho	3759	24	explain	explain	VB
cord-006229-7yoilsho	3759	25	the	the	DT
cord-006229-7yoilsho	3759	26	mutagenic	mutagenic	JJ
cord-006229-7yoilsho	3759	27	effect	effect	NN
cord-006229-7yoilsho	3759	28	.	.	.
cord-006229-7yoilsho	3760	1	This	this	DT
cord-006229-7yoilsho	3760	2	adducts	adduct	NNS
cord-006229-7yoilsho	3760	3	are	be	VBP
cord-006229-7yoilsho	3760	4	currently	currently	RB
cord-006229-7yoilsho	3760	5	isolated	isolate	VBN
cord-006229-7yoilsho	3760	6	,	,	,
cord-006229-7yoilsho	3760	7	characterized	characterize	VBN
cord-006229-7yoilsho	3760	8	by	by	IN
cord-006229-7yoilsho	3760	9	NMR	NMR	NNP
cord-006229-7yoilsho	3760	10	-	-	HYPH
cord-006229-7yoilsho	3760	11	spectroscopy	spectroscopy	NN
cord-006229-7yoilsho	3760	12	and	and	CC
cord-006229-7yoilsho	3760	13	used	use	VBD
cord-006229-7yoilsho	3760	14	to	to	TO
cord-006229-7yoilsho	3760	15	quantify	quantify	VB
cord-006229-7yoilsho	3760	16	adducts	adduct	NNS
cord-006229-7yoilsho	3760	17	in	in	IN
cord-006229-7yoilsho	3760	18	cells	cell	NNS
cord-006229-7yoilsho	3760	19	.	.	.
cord-006229-7yoilsho	3761	1	At	at	IN
cord-006229-7yoilsho	3761	2	the	the	DT
cord-006229-7yoilsho	3761	3	same	same	JJ
cord-006229-7yoilsho	3761	4	time	time	NN
cord-006229-7yoilsho	3761	5	primary	primary	JJ
cord-006229-7yoilsho	3761	6	rat	rat	NN
cord-006229-7yoilsho	3761	7	hepatocytes	hepatocyte	NNS
cord-006229-7yoilsho	3761	8	were	be	VBD
cord-006229-7yoilsho	3761	9	incubated	incubate	VBN
cord-006229-7yoilsho	3761	10	with	with	IN
cord-006229-7yoilsho	3761	11	non	non	JJ
cord-006229-7yoilsho	3761	12	-	-	JJ
cord-006229-7yoilsho	3761	13	cytotoxic	cytotoxic	JJ
cord-006229-7yoilsho	3761	14	concentrations	concentration	NNS
cord-006229-7yoilsho	3761	15	of	of	IN
cord-006229-7yoilsho	3761	16	aA	aA	NNP
cord-006229-7yoilsho	3761	17	and	and	CC
cord-006229-7yoilsho	3761	18	bA	bA	NNP
cord-006229-7yoilsho	3761	19	for	for	IN
cord-006229-7yoilsho	3761	20	24	24	CD
cord-006229-7yoilsho	3761	21	h.	h.	NN
cord-006229-7yoilsho	3761	22	After	after	IN
cord-006229-7yoilsho	3761	23	harvest	harvest	NN
cord-006229-7yoilsho	3761	24	and	and	CC
cord-006229-7yoilsho	3761	25	lysis	lysis	NN
cord-006229-7yoilsho	3761	26	of	of	IN
cord-006229-7yoilsho	3761	27	the	the	DT
cord-006229-7yoilsho	3761	28	cells	cell	NNS
cord-006229-7yoilsho	3761	29	,	,	,
cord-006229-7yoilsho	3761	30	the	the	DT
cord-006229-7yoilsho	3761	31	DNA	dna	NN
cord-006229-7yoilsho	3761	32	was	be	VBD
cord-006229-7yoilsho	3761	33	isolated	isolate	VBN
cord-006229-7yoilsho	3761	34	by	by	IN
cord-006229-7yoilsho	3761	35	chloroform	chloroform	NN
cord-006229-7yoilsho	3761	36	/	/	SYM
cord-006229-7yoilsho	3761	37	phenol	phenol	NN
cord-006229-7yoilsho	3761	38	extraction	extraction	NN
cord-006229-7yoilsho	3761	39	and	and	CC
cord-006229-7yoilsho	3761	40	enzymatically	enzymatically	RB
cord-006229-7yoilsho	3761	41	hydrolyzed	hydrolyze	VBN
cord-006229-7yoilsho	3761	42	.	.	.
cord-006229-7yoilsho	3762	1	[	[	-LRB-
cord-006229-7yoilsho	3762	2	4	4	CD
cord-006229-7yoilsho	3762	3	]	]	-RRB-
cord-006229-7yoilsho	3763	1	The	the	DT
cord-006229-7yoilsho	3763	2	residual	residual	JJ
cord-006229-7yoilsho	3763	3	hydrolysates	hydrolysate	NNS
cord-006229-7yoilsho	3763	4	will	will	MD
cord-006229-7yoilsho	3763	5	be	be	VB
cord-006229-7yoilsho	3763	6	used	use	VBN
cord-006229-7yoilsho	3763	7	to	to	TO
cord-006229-7yoilsho	3763	8	identify	identify	VB
cord-006229-7yoilsho	3763	9	the	the	DT
cord-006229-7yoilsho	3763	10	DNA	dna	NN
cord-006229-7yoilsho	3763	11	-	-	HYPH
cord-006229-7yoilsho	3763	12	adducts	adduct	NNS
cord-006229-7yoilsho	3763	13	formed	form	VBN
cord-006229-7yoilsho	3763	14	in	in	IN
cord-006229-7yoilsho	3763	15	cells	cell	NNS
cord-006229-7yoilsho	3763	16	and	and	CC
cord-006229-7yoilsho	3763	17	to	to	TO
cord-006229-7yoilsho	3763	18	determine	determine	VB
cord-006229-7yoilsho	3763	19	the	the	DT
cord-006229-7yoilsho	3763	20	adduct	adduct	NN
cord-006229-7yoilsho	3763	21	formation	formation	NN
cord-006229-7yoilsho	3763	22	rate	rate	NN
cord-006229-7yoilsho	3763	23	.	.	.
cord-006229-7yoilsho	3764	1	Preliminary	preliminary	JJ
cord-006229-7yoilsho	3764	2	experiments	experiment	NNS
cord-006229-7yoilsho	3764	3	indicate	indicate	VBP
cord-006229-7yoilsho	3764	4	that	that	IN
cord-006229-7yoilsho	3764	5	both	both	DT
cord-006229-7yoilsho	3764	6	,	,	,
cord-006229-7yoilsho	3764	7	aA	aA	NNP
cord-006229-7yoilsho	3764	8	and	and	CC
cord-006229-7yoilsho	3764	9	bA	bA	NNP
cord-006229-7yoilsho	3764	10	also	also	RB
cord-006229-7yoilsho	3764	11	form	form	VBP
cord-006229-7yoilsho	3764	12	DNA	dna	NN
cord-006229-7yoilsho	3764	13	-	-	HYPH
cord-006229-7yoilsho	3764	14	adducts	adduct	NNS
cord-006229-7yoilsho	3764	15	in	in	IN
cord-006229-7yoilsho	3764	16	intact	intact	JJ
cord-006229-7yoilsho	3764	17	cells	cell	NNS
cord-006229-7yoilsho	3764	18	in	in	IN
cord-006229-7yoilsho	3764	19	a	a	DT
cord-006229-7yoilsho	3764	20	concentration	concentration	NN
cord-006229-7yoilsho	3764	21	-	-	HYPH
cord-006229-7yoilsho	3764	22	dependent	dependent	JJ
cord-006229-7yoilsho	3764	23	manner	manner	NN
cord-006229-7yoilsho	3764	24	.	.	.
cord-006229-7yoilsho	3765	1	[	[	-LRB-
cord-006229-7yoilsho	3765	2	1	1	CD
cord-006229-7yoilsho	3765	3	]	]	-RRB-
cord-006229-7yoilsho	3765	4	Göggmann	Göggmann	NNP
cord-006229-7yoilsho	3765	5	,	,	,
cord-006229-7yoilsho	3765	6	Schimmer	Schimmer	NNP
cord-006229-7yoilsho	3765	7	(	(	-LRB-
cord-006229-7yoilsho	3765	8	1983	1983	CD
cord-006229-7yoilsho	3765	9	)	)	-RRB-
cord-006229-7yoilsho	3765	10	.	.	.
cord-006229-7yoilsho	3766	1	Mutagenicity	mutagenicity	NN
cord-006229-7yoilsho	3766	2	testing	testing	NN
cord-006229-7yoilsho	3766	3	of	of	IN
cord-006229-7yoilsho	3766	4	α	α	NN
cord-006229-7yoilsho	3766	5	-	-	HYPH
cord-006229-7yoilsho	3766	6	asarone	asarone	JJ
cord-006229-7yoilsho	3766	7	and	and	CC
cord-006229-7yoilsho	3766	8	commercial	commercial	JJ
cord-006229-7yoilsho	3766	9	calamus	calamus	NN
cord-006229-7yoilsho	3766	10	drugs	drug	NNS
cord-006229-7yoilsho	3766	11	with	with	IN
cord-006229-7yoilsho	3766	12	Salmonella	Salmonella	NNP
cord-006229-7yoilsho	3766	13	typhimurium	typhimurium	NN
cord-006229-7yoilsho	3766	14	.	.	.
cord-006229-7yoilsho	3767	1	Mutation	Mutation	NNP
cord-006229-7yoilsho	3767	2	Research	Research	NNP
cord-006229-7yoilsho	3767	3	.	.	.
cord-006229-7yoilsho	3768	1	121	121	CD
cord-006229-7yoilsho	3768	2	,	,	,
cord-006229-7yoilsho	3768	3	[	[	-LRB-
cord-006229-7yoilsho	3768	4	191	191	CD
cord-006229-7yoilsho	3768	5	]	]	-RRB-
cord-006229-7yoilsho	3768	6	[	[	-LRB-
cord-006229-7yoilsho	3768	7	192	192	CD
cord-006229-7yoilsho	3768	8	]	]	-RRB-
cord-006229-7yoilsho	3768	9	[	[	-LRB-
cord-006229-7yoilsho	3768	10	193	193	CD
cord-006229-7yoilsho	3768	11	]	]	-RRB-
cord-006229-7yoilsho	3768	12	[	[	-LRB-
cord-006229-7yoilsho	3768	13	194	194	CD
cord-006229-7yoilsho	3768	14	]	]	-RRB-
cord-006229-7yoilsho	3769	1	Wiseman	Wiseman	NNP
cord-006229-7yoilsho	3769	2	et	et	NNP
cord-006229-7yoilsho	3769	3	al	al	NNP
cord-006229-7yoilsho	3769	4	.	.	.
cord-006229-7yoilsho	3770	1	Fatty	fatty	JJ
cord-006229-7yoilsho	3770	2	acid	acid	NN
cord-006229-7yoilsho	3770	3	esters	ester	NNS
cord-006229-7yoilsho	3770	4	of	of	IN
cord-006229-7yoilsho	3770	5	3-chloro-1	3-chloro-1	CD
cord-006229-7yoilsho	3770	6	,	,	,
cord-006229-7yoilsho	3770	7	and	and	CC
cord-006229-7yoilsho	3770	8	of	of	IN
cord-006229-7yoilsho	3770	9	2-chloro-1	2-chloro-1	CD
cord-006229-7yoilsho	3770	10	,	,	,
cord-006229-7yoilsho	3770	11	are	be	VBP
cord-006229-7yoilsho	3770	12	food	food	NN
cord-006229-7yoilsho	3770	13	process	process	NN
cord-006229-7yoilsho	3770	14	contaminants	contaminant	NNS
cord-006229-7yoilsho	3770	15	that	that	WDT
cord-006229-7yoilsho	3770	16	are	be	VBP
cord-006229-7yoilsho	3770	17	formed	form	VBN
cord-006229-7yoilsho	3770	18	,	,	,
cord-006229-7yoilsho	3770	19	e.g.	e.g.	RB
cord-006229-7yoilsho	3770	20	,	,	,
cord-006229-7yoilsho	3770	21	during	during	IN
cord-006229-7yoilsho	3770	22	refinement	refinement	NN
cord-006229-7yoilsho	3770	23	of	of	IN
cord-006229-7yoilsho	3770	24	vegetable	vegetable	NN
cord-006229-7yoilsho	3770	25	oils	oil	NNS
cord-006229-7yoilsho	3770	26	.	.	.
cord-006229-7yoilsho	3771	1	After	after	IN
cord-006229-7yoilsho	3771	2	ingestion	ingestion	NN
cord-006229-7yoilsho	3771	3	,	,	,
cord-006229-7yoilsho	3771	4	the	the	DT
cord-006229-7yoilsho	3771	5	esters	ester	NNS
cord-006229-7yoilsho	3771	6	are	be	VBP
cord-006229-7yoilsho	3771	7	hydrolyzed	hydrolyze	VBN
cord-006229-7yoilsho	3771	8	in	in	IN
cord-006229-7yoilsho	3771	9	the	the	DT
cord-006229-7yoilsho	3771	10	gut	gut	NN
cord-006229-7yoilsho	3771	11	,	,	,
cord-006229-7yoilsho	3771	12	thereby	thereby	RB
cord-006229-7yoilsho	3771	13	releasing	release	VBG
cord-006229-7yoilsho	3771	14	free	free	JJ
cord-006229-7yoilsho	3771	15	3-MCPD	3-mcpd	CD
cord-006229-7yoilsho	3771	16	and	and	CC
cord-006229-7yoilsho	3771	17	2-MCPD	2-mcpd	CD
cord-006229-7yoilsho	3771	18	.	.	.
cord-006229-7yoilsho	3772	1	3-MCPD	3-MCPD	NNP
cord-006229-7yoilsho	3772	2	has	have	VBZ
cord-006229-7yoilsho	3772	3	been	be	VBN
cord-006229-7yoilsho	3772	4	identified	identify	VBN
cord-006229-7yoilsho	3772	5	by	by	IN
cord-006229-7yoilsho	3772	6	the	the	DT
cord-006229-7yoilsho	3772	7	International	International	NNP
cord-006229-7yoilsho	3772	8	Agency	Agency	NNP
cord-006229-7yoilsho	3772	9	for	for	IN
cord-006229-7yoilsho	3772	10	Research	Research	NNP
cord-006229-7yoilsho	3772	11	on	on	IN
cord-006229-7yoilsho	3772	12	Cancer	Cancer	NNP
cord-006229-7yoilsho	3772	13	(	(	-LRB-
cord-006229-7yoilsho	3772	14	IARC	IARC	NNP
cord-006229-7yoilsho	3772	15	)	)	-RRB-
cord-006229-7yoilsho	3772	16	to	to	TO
cord-006229-7yoilsho	3772	17	be	be	VB
cord-006229-7yoilsho	3772	18	possibly	possibly	RB
cord-006229-7yoilsho	3772	19	carcinogenic	carcinogenic	JJ
cord-006229-7yoilsho	3772	20	to	to	IN
cord-006229-7yoilsho	3772	21	humans	human	NNS
cord-006229-7yoilsho	3772	22	(	(	-LRB-
cord-006229-7yoilsho	3772	23	class	class	NNP
cord-006229-7yoilsho	3772	24	2B	2b	CD
cord-006229-7yoilsho	3772	25	)	)	-RRB-
cord-006229-7yoilsho	3772	26	and	and	CC
cord-006229-7yoilsho	3772	27	is	be	VBZ
cord-006229-7yoilsho	3772	28	therefore	therefore	RB
cord-006229-7yoilsho	3772	29	in	in	IN
cord-006229-7yoilsho	3772	30	the	the	DT
cord-006229-7yoilsho	3772	31	focus	focus	NN
cord-006229-7yoilsho	3772	32	of	of	IN
cord-006229-7yoilsho	3772	33	food	food	NN
cord-006229-7yoilsho	3772	34	safety	safety	NN
cord-006229-7yoilsho	3772	35	authorities	authority	NNS
cord-006229-7yoilsho	3772	36	.	.	.
cord-006229-7yoilsho	3773	1	To	to	TO
cord-006229-7yoilsho	3773	2	elucidate	elucidate	VB
cord-006229-7yoilsho	3773	3	the	the	DT
cord-006229-7yoilsho	3773	4	toxicological	toxicological	JJ
cord-006229-7yoilsho	3773	5	properties	property	NNS
cord-006229-7yoilsho	3773	6	of	of	IN
cord-006229-7yoilsho	3773	7	these	these	DT
cord-006229-7yoilsho	3773	8	compounds	compound	NNS
cord-006229-7yoilsho	3773	9	at	at	IN
cord-006229-7yoilsho	3773	10	the	the	DT
cord-006229-7yoilsho	3773	11	molecular	molecular	JJ
cord-006229-7yoilsho	3773	12	level	level	NN
cord-006229-7yoilsho	3773	13	(	(	-LRB-
cord-006229-7yoilsho	3773	14	Mode	mode	NN
cord-006229-7yoilsho	3773	15	of	of	IN
cord-006229-7yoilsho	3773	16	Action	Action	NNP
cord-006229-7yoilsho	3773	17	)	)	-RRB-
cord-006229-7yoilsho	3774	1	a	a	DT
cord-006229-7yoilsho	3774	2	proteomic	proteomic	JJ
cord-006229-7yoilsho	3774	3	study	study	NN
cord-006229-7yoilsho	3774	4	was	be	VBD
cord-006229-7yoilsho	3774	5	conducted	conduct	VBN
cord-006229-7yoilsho	3774	6	in	in	IN
cord-006229-7yoilsho	3774	7	which	which	WDT
cord-006229-7yoilsho	3774	8	10	10	CD
cord-006229-7yoilsho	3774	9	mg	mg	NNP
cord-006229-7yoilsho	3774	10	/	/	SYM
cord-006229-7yoilsho	3774	11	kg	kg	NNP
cord-006229-7yoilsho	3774	12	b.w./day	b.w./day	DT
cord-006229-7yoilsho	3774	13	of	of	IN
cord-006229-7yoilsho	3774	14	either	either	DT
cord-006229-7yoilsho	3774	15	3-MCPD	3-mcpd	CD
cord-006229-7yoilsho	3774	16	or	or	CC
cord-006229-7yoilsho	3774	17	2-MCPD	2-mcpd	CD
cord-006229-7yoilsho	3774	18	were	be	VBD
cord-006229-7yoilsho	3774	19	orally	orally	RB
cord-006229-7yoilsho	3774	20	administered	administer	VBN
cord-006229-7yoilsho	3774	21	to	to	IN
cord-006229-7yoilsho	3774	22	rats	rat	NNS
cord-006229-7yoilsho	3774	23	over	over	IN
cord-006229-7yoilsho	3774	24	a	a	DT
cord-006229-7yoilsho	3774	25	period	period	NN
cord-006229-7yoilsho	3774	26	of	of	IN
cord-006229-7yoilsho	3774	27	28	28	CD
cord-006229-7yoilsho	3774	28	days	day	NNS
cord-006229-7yoilsho	3774	29	.	.	.
cord-006229-7yoilsho	3775	1	Total	total	JJ
cord-006229-7yoilsho	3775	2	protein	protein	NN
cord-006229-7yoilsho	3775	3	was	be	VBD
cord-006229-7yoilsho	3775	4	extracted	extract	VBN
cord-006229-7yoilsho	3775	5	from	from	IN
cord-006229-7yoilsho	3775	6	different	different	JJ
cord-006229-7yoilsho	3775	7	tissues	tissue	NNS
cord-006229-7yoilsho	3775	8	of	of	IN
cord-006229-7yoilsho	3775	9	the	the	DT
cord-006229-7yoilsho	3775	10	animals	animal	NNS
cord-006229-7yoilsho	3775	11	and	and	CC
cord-006229-7yoilsho	3775	12	separated	separate	VBD
cord-006229-7yoilsho	3775	13	via	via	IN
cord-006229-7yoilsho	3775	14	twodimensional	twodimensional	NNP
cord-006229-7yoilsho	3775	15	gel	gel	NN
cord-006229-7yoilsho	3775	16	electrophoresis	electrophoresis	NN
cord-006229-7yoilsho	3775	17	(	(	-LRB-
cord-006229-7yoilsho	3775	18	2DE	2de	CD
cord-006229-7yoilsho	3775	19	)	)	-RRB-
cord-006229-7yoilsho	3775	20	.	.	.
cord-006229-7yoilsho	3776	1	Among	among	IN
cord-006229-7yoilsho	3776	2	others	other	NNS
cord-006229-7yoilsho	3776	3	,	,	,
cord-006229-7yoilsho	3776	4	the	the	DT
cord-006229-7yoilsho	3776	5	redox	redox	NN
cord-006229-7yoilsho	3776	6	sensor	sensor	NN
cord-006229-7yoilsho	3776	7	protein	protein	NN
cord-006229-7yoilsho	3776	8	DJ-1	DJ-1	NNP
cord-006229-7yoilsho	3776	9	was	be	VBD
cord-006229-7yoilsho	3776	10	identified	identify	VBN
cord-006229-7yoilsho	3776	11	to	to	TO
cord-006229-7yoilsho	3776	12	be	be	VB
cord-006229-7yoilsho	3776	13	deregulated	deregulate	VBN
cord-006229-7yoilsho	3776	14	in	in	IN
cord-006229-7yoilsho	3776	15	liver	liver	NN
cord-006229-7yoilsho	3776	16	,	,	,
cord-006229-7yoilsho	3776	17	kidney	kidney	NN
cord-006229-7yoilsho	3776	18	,	,	,
cord-006229-7yoilsho	3776	19	testis	testis	NN
cord-006229-7yoilsho	3776	20	,	,	,
cord-006229-7yoilsho	3776	21	and	and	CC
cord-006229-7yoilsho	3776	22	heart	heart	NN
cord-006229-7yoilsho	3776	23	of	of	IN
cord-006229-7yoilsho	3776	24	rats	rat	NNS
cord-006229-7yoilsho	3776	25	treated	treat	VBN
cord-006229-7yoilsho	3776	26	either	either	CC
cord-006229-7yoilsho	3776	27	with	with	IN
cord-006229-7yoilsho	3776	28	3-MCPD	3-mcpd	CD
cord-006229-7yoilsho	3776	29	or	or	CC
cord-006229-7yoilsho	3776	30	2-MCPD	2-mcpd	CD
cord-006229-7yoilsho	3776	31	.	.	.
cord-006229-7yoilsho	3777	1	Up	up	IN
cord-006229-7yoilsho	3777	2	to	to	TO
cord-006229-7yoilsho	3777	3	six	six	CD
cord-006229-7yoilsho	3777	4	different	different	JJ
cord-006229-7yoilsho	3777	5	isoforms	isoform	NNS
cord-006229-7yoilsho	3777	6	of	of	IN
cord-006229-7yoilsho	3777	7	DJ-1	DJ-1	NNP
cord-006229-7yoilsho	3777	8	were	be	VBD
cord-006229-7yoilsho	3777	9	identified	identify	VBN
cord-006229-7yoilsho	3777	10	by	by	IN
cord-006229-7yoilsho	3777	11	2DE	2de	CD
cord-006229-7yoilsho	3777	12	-	-	HYPH
cord-006229-7yoilsho	3777	13	Western	western	JJ
cord-006229-7yoilsho	3777	14	blot	blot	NN
cord-006229-7yoilsho	3777	15	analysis	analysis	NN
cord-006229-7yoilsho	3777	16	,	,	,
cord-006229-7yoilsho	3777	17	all	all	DT
cord-006229-7yoilsho	3777	18	of	of	IN
cord-006229-7yoilsho	3777	19	them	-PRON-	PRP
cord-006229-7yoilsho	3777	20	having	have	VBG
cord-006229-7yoilsho	3777	21	the	the	DT
cord-006229-7yoilsho	3777	22	same	same	JJ
cord-006229-7yoilsho	3777	23	molecular	molecular	JJ
cord-006229-7yoilsho	3777	24	weight	weight	NN
cord-006229-7yoilsho	3777	25	but	but	CC
cord-006229-7yoilsho	3777	26	different	different	JJ
cord-006229-7yoilsho	3777	27	pI	pi	NN
cord-006229-7yoilsho	3777	28	values	value	NNS
cord-006229-7yoilsho	3777	29	,	,	,
cord-006229-7yoilsho	3777	30	indicating	indicate	VBG
cord-006229-7yoilsho	3777	31	protein	protein	NN
cord-006229-7yoilsho	3777	32	modifications	modification	NNS
cord-006229-7yoilsho	3777	33	of	of	IN
cord-006229-7yoilsho	3777	34	low	low	JJ
cord-006229-7yoilsho	3777	35	molecular	molecular	JJ
cord-006229-7yoilsho	3777	36	weight	weight	NN
cord-006229-7yoilsho	3777	37	but	but	CC
cord-006229-7yoilsho	3777	38	with	with	IN
cord-006229-7yoilsho	3777	39	a	a	DT
cord-006229-7yoilsho	3777	40	strong	strong	JJ
cord-006229-7yoilsho	3777	41	impact	impact	NN
cord-006229-7yoilsho	3777	42	on	on	IN
cord-006229-7yoilsho	3777	43	the	the	DT
cord-006229-7yoilsho	3777	44	protein	protein	NN
cord-006229-7yoilsho	3777	45	charge	charge	NN
cord-006229-7yoilsho	3777	46	.	.	.
cord-006229-7yoilsho	3778	1	Treatment	treatment	NN
cord-006229-7yoilsho	3778	2	of	of	IN
cord-006229-7yoilsho	3778	3	the	the	DT
cord-006229-7yoilsho	3778	4	animals	animal	NNS
cord-006229-7yoilsho	3778	5	with	with	IN
cord-006229-7yoilsho	3778	6	either	either	DT
cord-006229-7yoilsho	3778	7	3-MCPD	3-mcpd	CD
cord-006229-7yoilsho	3778	8	or	or	CC
cord-006229-7yoilsho	3778	9	2-MCPD	2-mcpd	CD
cord-006229-7yoilsho	3778	10	predominantly	predominantly	RB
cord-006229-7yoilsho	3778	11	led	lead	VBN
cord-006229-7yoilsho	3778	12	to	to	IN
cord-006229-7yoilsho	3778	13	a	a	DT
cord-006229-7yoilsho	3778	14	shift	shift	NN
cord-006229-7yoilsho	3778	15	of	of	IN
cord-006229-7yoilsho	3778	16	the	the	DT
cord-006229-7yoilsho	3778	17	abundance	abundance	NN
cord-006229-7yoilsho	3778	18	between	between	IN
cord-006229-7yoilsho	3778	19	two	two	CD
cord-006229-7yoilsho	3778	20	DJ-1	DJ-1	NNP
cord-006229-7yoilsho	3778	21	isoforms	isoform	NNS
cord-006229-7yoilsho	3778	22	in	in	IN
cord-006229-7yoilsho	3778	23	the	the	DT
cord-006229-7yoilsho	3778	24	rat	rat	NN
cord-006229-7yoilsho	3778	25	tissues	tissue	NNS
cord-006229-7yoilsho	3778	26	.	.	.
cord-006229-7yoilsho	3779	1	This	this	DT
cord-006229-7yoilsho	3779	2	effect	effect	NN
cord-006229-7yoilsho	3779	3	was	be	VBD
cord-006229-7yoilsho	3779	4	more	more	RBR
cord-006229-7yoilsho	3779	5	pronounced	pronounce	VBN
cord-006229-7yoilsho	3779	6	with	with	IN
cord-006229-7yoilsho	3779	7	3-MCPD	3-mcpd	CD
cord-006229-7yoilsho	3779	8	compared	compare	VBN
cord-006229-7yoilsho	3779	9	to	to	IN
cord-006229-7yoilsho	3779	10	2-MCPD	2-mcpd	CD
cord-006229-7yoilsho	3779	11	.	.	.
cord-006229-7yoilsho	3780	1	Mass	Mass	NNP
cord-006229-7yoilsho	3780	2	spectrometric	spectrometric	JJ
cord-006229-7yoilsho	3780	3	analysis	analysis	NN
cord-006229-7yoilsho	3780	4	of	of	IN
cord-006229-7yoilsho	3780	5	these	these	DT
cord-006229-7yoilsho	3780	6	two	two	CD
cord-006229-7yoilsho	3780	7	isoforms	isoform	NNS
cord-006229-7yoilsho	3780	8	identified	identify	VBD
cord-006229-7yoilsho	3780	9	an	an	DT
cord-006229-7yoilsho	3780	10	oxidation	oxidation	NN
cord-006229-7yoilsho	3780	11	of	of	IN
cord-006229-7yoilsho	3780	12	a	a	DT
cord-006229-7yoilsho	3780	13	conserved	conserve	VBN
cord-006229-7yoilsho	3780	14	cysteine	cysteine	NN
cord-006229-7yoilsho	3780	15	residue	residue	NN
cord-006229-7yoilsho	3780	16	(	(	-LRB-
cord-006229-7yoilsho	3780	17	Cys106	cys106	CD
cord-006229-7yoilsho	3780	18	)	)	-RRB-
cord-006229-7yoilsho	3780	19	of	of	IN
cord-006229-7yoilsho	3780	20	DJ-1	DJ-1	NNP
cord-006229-7yoilsho	3780	21	to	to	IN
cord-006229-7yoilsho	3780	22	a	a	DT
cord-006229-7yoilsho	3780	23	cysteine	cysteine	NN
cord-006229-7yoilsho	3780	24	sulfonic	sulfonic	JJ
cord-006229-7yoilsho	3780	25	acid	acid	NN
cord-006229-7yoilsho	3780	26	to	to	TO
cord-006229-7yoilsho	3780	27	be	be	VB
cord-006229-7yoilsho	3780	28	the	the	DT
cord-006229-7yoilsho	3780	29	protein	protein	NN
cord-006229-7yoilsho	3780	30	modification	modification	NN
cord-006229-7yoilsho	3780	31	induced	induce	VBN
cord-006229-7yoilsho	3780	32	by	by	IN
cord-006229-7yoilsho	3780	33	treatment	treatment	NN
cord-006229-7yoilsho	3780	34	of	of	IN
cord-006229-7yoilsho	3780	35	the	the	DT
cord-006229-7yoilsho	3780	36	rats	rat	NNS
cord-006229-7yoilsho	3780	37	with	with	IN
cord-006229-7yoilsho	3780	38	either	either	DT
cord-006229-7yoilsho	3780	39	3-MCPD	3-mcpd	CD
cord-006229-7yoilsho	3780	40	or	or	CC
cord-006229-7yoilsho	3780	41	2-MCPD	2-mcpd	CD
cord-006229-7yoilsho	3780	42	.	.	.
cord-006229-7yoilsho	3781	1	DJ-1	DJ-1	NNP
cord-006229-7yoilsho	3781	2	is	be	VBZ
cord-006229-7yoilsho	3781	3	discussed	discuss	VBN
cord-006229-7yoilsho	3781	4	to	to	TO
cord-006229-7yoilsho	3781	5	participate	participate	VB
cord-006229-7yoilsho	3781	6	in	in	IN
cord-006229-7yoilsho	3781	7	a	a	DT
cord-006229-7yoilsho	3781	8	number	number	NN
cord-006229-7yoilsho	3781	9	of	of	IN
cord-006229-7yoilsho	3781	10	biological	biological	JJ
cord-006229-7yoilsho	3781	11	processes	process	NNS
cord-006229-7yoilsho	3781	12	such	such	JJ
cord-006229-7yoilsho	3781	13	as	as	IN
cord-006229-7yoilsho	3781	14	proteolysis	proteolysis	NN
cord-006229-7yoilsho	3781	15	,	,	,
cord-006229-7yoilsho	3781	16	protein	protein	NN
cord-006229-7yoilsho	3781	17	folding	folding	NN
cord-006229-7yoilsho	3781	18	,	,	,
cord-006229-7yoilsho	3781	19	or	or	CC
cord-006229-7yoilsho	3781	20	redox	redox	NN
cord-006229-7yoilsho	3781	21	regulation	regulation	NN
cord-006229-7yoilsho	3781	22	.	.	.
cord-006229-7yoilsho	3782	1	Oxidation	oxidation	NN
cord-006229-7yoilsho	3782	2	of	of	IN
cord-006229-7yoilsho	3782	3	Cys106	cys106	CD
cord-006229-7yoilsho	3782	4	was	be	VBD
cord-006229-7yoilsho	3782	5	shown	show	VBN
cord-006229-7yoilsho	3782	6	to	to	TO
cord-006229-7yoilsho	3782	7	be	be	VB
cord-006229-7yoilsho	3782	8	crucial	crucial	JJ
cord-006229-7yoilsho	3782	9	for	for	IN
cord-006229-7yoilsho	3782	10	the	the	DT
cord-006229-7yoilsho	3782	11	activity	activity	NN
cord-006229-7yoilsho	3782	12	of	of	IN
cord-006229-7yoilsho	3782	13	DJ-1	DJ-1	NNP
cord-006229-7yoilsho	3782	14	,	,	,
cord-006229-7yoilsho	3782	15	and	and	CC
cord-006229-7yoilsho	3782	16	the	the	DT
cord-006229-7yoilsho	3782	17	irreversible	irreversible	JJ
cord-006229-7yoilsho	3782	18	oxidation	oxidation	NN
cord-006229-7yoilsho	3782	19	of	of	IN
cord-006229-7yoilsho	3782	20	Cys106	cys106	CD
cord-006229-7yoilsho	3782	21	to	to	IN
cord-006229-7yoilsho	3782	22	a	a	DT
cord-006229-7yoilsho	3782	23	cysteine	cysteine	NN
cord-006229-7yoilsho	3782	24	sulfonic	sulfonic	JJ
cord-006229-7yoilsho	3782	25	acid	acid	NN
cord-006229-7yoilsho	3782	26	as	as	IN
cord-006229-7yoilsho	3782	27	observed	observe	VBN
cord-006229-7yoilsho	3782	28	in	in	IN
cord-006229-7yoilsho	3782	29	the	the	DT
cord-006229-7yoilsho	3782	30	present	present	JJ
cord-006229-7yoilsho	3782	31	study	study	NN
cord-006229-7yoilsho	3782	32	was	be	VBD
cord-006229-7yoilsho	3782	33	shown	show	VBN
cord-006229-7yoilsho	3782	34	to	to	TO
cord-006229-7yoilsho	3782	35	result	result	VB
cord-006229-7yoilsho	3782	36	in	in	IN
cord-006229-7yoilsho	3782	37	a	a	DT
cord-006229-7yoilsho	3782	38	loss	loss	NN
cord-006229-7yoilsho	3782	39	of	of	IN
cord-006229-7yoilsho	3782	40	protein	protein	NN
cord-006229-7yoilsho	3782	41	function	function	NN
cord-006229-7yoilsho	3782	42	and	and	CC
cord-006229-7yoilsho	3782	43	was	be	VBD
cord-006229-7yoilsho	3782	44	correlated	correlate	VBN
cord-006229-7yoilsho	3782	45	with	with	IN
cord-006229-7yoilsho	3782	46	diseases	disease	NNS
cord-006229-7yoilsho	3782	47	related	relate	VBN
cord-006229-7yoilsho	3782	48	to	to	IN
cord-006229-7yoilsho	3782	49	oxidative	oxidative	JJ
cord-006229-7yoilsho	3782	50	stress	stress	NN
cord-006229-7yoilsho	3782	51	such	such	JJ
cord-006229-7yoilsho	3782	52	as	as	IN
cord-006229-7yoilsho	3782	53	Parkinson	Parkinson	NNP
cord-006229-7yoilsho	3782	54	's	's	POS
cord-006229-7yoilsho	3782	55	disease	disease	NN
cord-006229-7yoilsho	3782	56	.	.	.
cord-006229-7yoilsho	3783	1	Thus	thus	RB
cord-006229-7yoilsho	3783	2	,	,	,
cord-006229-7yoilsho	3783	3	the	the	DT
cord-006229-7yoilsho	3783	4	potential	potential	JJ
cord-006229-7yoilsho	3783	5	impact	impact	NN
cord-006229-7yoilsho	3783	6	of	of	IN
cord-006229-7yoilsho	3783	7	3-MCPD	3-mcpd	CD
cord-006229-7yoilsho	3783	8	and	and	CC
cord-006229-7yoilsho	3783	9	2-MCPD	2-mcpd	CD
cord-006229-7yoilsho	3783	10	on	on	IN
cord-006229-7yoilsho	3783	11	cellular	cellular	JJ
cord-006229-7yoilsho	3783	12	oxidative	oxidative	JJ
cord-006229-7yoilsho	3783	13	stress	stress	NN
cord-006229-7yoilsho	3783	14	and	and	CC
cord-006229-7yoilsho	3783	15	on	on	IN
cord-006229-7yoilsho	3783	16	associated	associated	JJ
cord-006229-7yoilsho	3783	17	neurodegenerative	neurodegenerative	JJ
cord-006229-7yoilsho	3783	18	diseases	disease	NNS
cord-006229-7yoilsho	3783	19	has	have	VBZ
cord-006229-7yoilsho	3783	20	to	to	TO
cord-006229-7yoilsho	3783	21	be	be	VB
cord-006229-7yoilsho	3783	22	considered	consider	VBN
cord-006229-7yoilsho	3783	23	in	in	IN
cord-006229-7yoilsho	3783	24	the	the	DT
cord-006229-7yoilsho	3783	25	ongoing	ongoing	JJ
cord-006229-7yoilsho	3783	26	risk	risk	NN
cord-006229-7yoilsho	3783	27	assessment	assessment	NN
cord-006229-7yoilsho	3783	28	of	of	IN
cord-006229-7yoilsho	3783	29	these	these	DT
cord-006229-7yoilsho	3783	30	food	food	NN
cord-006229-7yoilsho	3783	31	contaminants	contaminant	NNS
cord-006229-7yoilsho	3783	32	.	.	.
cord-006229-7yoilsho	3784	1	Pyrrolizidine	Pyrrolizidine	NNP
cord-006229-7yoilsho	3784	2	alkaloids	alkaloid	NNS
cord-006229-7yoilsho	3784	3	(	(	-LRB-
cord-006229-7yoilsho	3784	4	PA	PA	NNP
cord-006229-7yoilsho	3784	5	)	)	-RRB-
cord-006229-7yoilsho	3784	6	are	be	VBP
cord-006229-7yoilsho	3784	7	secondary	secondary	JJ
cord-006229-7yoilsho	3784	8	plant	plant	NN
cord-006229-7yoilsho	3784	9	compounds	compound	NNS
cord-006229-7yoilsho	3784	10	and	and	CC
cord-006229-7yoilsho	3784	11	widely	widely	RB
cord-006229-7yoilsho	3784	12	spread	spread	VBN
cord-006229-7yoilsho	3784	13	in	in	IN
cord-006229-7yoilsho	3784	14	plant	plant	NN
cord-006229-7yoilsho	3784	15	kingdom	kingdom	NN
cord-006229-7yoilsho	3784	16	.	.	.
cord-006229-7yoilsho	3785	1	Humans	human	NNS
cord-006229-7yoilsho	3785	2	can	can	MD
cord-006229-7yoilsho	3785	3	therefore	therefore	RB
cord-006229-7yoilsho	3785	4	be	be	VB
cord-006229-7yoilsho	3785	5	regularly	regularly	RB
cord-006229-7yoilsho	3785	6	exposed	expose	VBN
cord-006229-7yoilsho	3785	7	via	via	IN
cord-006229-7yoilsho	3785	8	direct	direct	JJ
cord-006229-7yoilsho	3785	9	or	or	CC
cord-006229-7yoilsho	3785	10	indirect	indirect	JJ
cord-006229-7yoilsho	3785	11	contamination	contamination	NN
cord-006229-7yoilsho	3785	12	of	of	IN
cord-006229-7yoilsho	3785	13	food	food	NN
cord-006229-7yoilsho	3785	14	,	,	,
cord-006229-7yoilsho	3785	15	like	like	IN
cord-006229-7yoilsho	3785	16	herbal	herbal	JJ
cord-006229-7yoilsho	3785	17	teas	tea	NNS
cord-006229-7yoilsho	3785	18	,	,	,
cord-006229-7yoilsho	3785	19	honey	honey	NN
cord-006229-7yoilsho	3785	20	,	,	,
cord-006229-7yoilsho	3785	21	wheat	wheat	NN
cord-006229-7yoilsho	3785	22	or	or	CC
cord-006229-7yoilsho	3785	23	salad	salad	NN
cord-006229-7yoilsho	3785	24	.	.	.
cord-006229-7yoilsho	3786	1	1,2-unsaturated	1,2-unsaturated	JJ
cord-006229-7yoilsho	3786	2	PA	PA	NNP
cord-006229-7yoilsho	3786	3	are	be	VBP
cord-006229-7yoilsho	3786	4	known	know	VBN
cord-006229-7yoilsho	3786	5	for	for	IN
cord-006229-7yoilsho	3786	6	their	-PRON-	PRP$
cord-006229-7yoilsho	3786	7	potentially	potentially	RB
cord-006229-7yoilsho	3786	8	harmful	harmful	JJ
cord-006229-7yoilsho	3786	9	effects	effect	NNS
cord-006229-7yoilsho	3786	10	.	.	.
cord-006229-7yoilsho	3787	1	An	an	DT
cord-006229-7yoilsho	3787	2	acute	acute	JJ
cord-006229-7yoilsho	3787	3	intoxication	intoxication	NN
cord-006229-7yoilsho	3787	4	may	may	MD
cord-006229-7yoilsho	3787	5	cause	cause	VB
cord-006229-7yoilsho	3787	6	venoocclusive	venoocclusive	JJ
cord-006229-7yoilsho	3787	7	disease	disease	NN
cord-006229-7yoilsho	3787	8	leading	lead	VBG
cord-006229-7yoilsho	3787	9	to	to	IN
cord-006229-7yoilsho	3787	10	hepatomegaly	hepatomegaly	NNP
cord-006229-7yoilsho	3787	11	,	,	,
cord-006229-7yoilsho	3787	12	ascites	ascite	NNS
cord-006229-7yoilsho	3787	13	as	as	RB
cord-006229-7yoilsho	3787	14	well	well	RB
cord-006229-7yoilsho	3787	15	as	as	IN
cord-006229-7yoilsho	3787	16	liver	liver	NN
cord-006229-7yoilsho	3787	17	hardening	hardening	NN
cord-006229-7yoilsho	3787	18	resulting	result	VBG
cord-006229-7yoilsho	3787	19	in	in	IN
cord-006229-7yoilsho	3787	20	high	high	JJ
cord-006229-7yoilsho	3787	21	mortality	mortality	NN
cord-006229-7yoilsho	3787	22	.	.	.
cord-006229-7yoilsho	3788	1	On	on	IN
cord-006229-7yoilsho	3788	2	the	the	DT
cord-006229-7yoilsho	3788	3	other	other	JJ
cord-006229-7yoilsho	3788	4	hand	hand	NN
cord-006229-7yoilsho	3788	5	,	,	,
cord-006229-7yoilsho	3788	6	chronic	chronic	JJ
cord-006229-7yoilsho	3788	7	PA	PA	NNP
cord-006229-7yoilsho	3788	8	intoxications	intoxication	NNS
cord-006229-7yoilsho	3788	9	due	due	JJ
cord-006229-7yoilsho	3788	10	to	to	IN
cord-006229-7yoilsho	3788	11	regular	regular	JJ
cord-006229-7yoilsho	3788	12	consumption	consumption	NN
cord-006229-7yoilsho	3788	13	of	of	IN
cord-006229-7yoilsho	3788	14	small	small	JJ
cord-006229-7yoilsho	3788	15	amounts	amount	NNS
cord-006229-7yoilsho	3788	16	of	of	IN
cord-006229-7yoilsho	3788	17	PA	PA	NNP
cord-006229-7yoilsho	3788	18	are	be	VBP
cord-006229-7yoilsho	3788	19	characterized	characterize	VBN
cord-006229-7yoilsho	3788	20	by	by	IN
cord-006229-7yoilsho	3788	21	hepatic	hepatic	JJ
cord-006229-7yoilsho	3788	22	necrosis	necrosis	NN
cord-006229-7yoilsho	3788	23	,	,	,
cord-006229-7yoilsho	3788	24	fibrosis	fibrosis	NN
cord-006229-7yoilsho	3788	25	and	and	CC
cord-006229-7yoilsho	3788	26	cirrhosis	cirrhosis	NN
cord-006229-7yoilsho	3788	27	.	.	.
cord-006229-7yoilsho	3789	1	An	an	DT
cord-006229-7yoilsho	3789	2	initial	initial	JJ
cord-006229-7yoilsho	3789	3	whole	whole	JJ
cord-006229-7yoilsho	3789	4	genome	genome	NN
cord-006229-7yoilsho	3789	5	transcriptome	transcriptome	NN
cord-006229-7yoilsho	3789	6	study	study	NN
cord-006229-7yoilsho	3789	7	in	in	IN
cord-006229-7yoilsho	3789	8	hepatocytes	hepatocyte	NNS
cord-006229-7yoilsho	3789	9	revealed	reveal	VBD
cord-006229-7yoilsho	3789	10	that	that	IN
cord-006229-7yoilsho	3789	11	molecular	molecular	JJ
cord-006229-7yoilsho	3789	12	pathways	pathway	NNS
cord-006229-7yoilsho	3789	13	related	relate	VBN
cord-006229-7yoilsho	3789	14	to	to	IN
cord-006229-7yoilsho	3789	15	cancer	cancer	NN
cord-006229-7yoilsho	3789	16	development	development	NN
cord-006229-7yoilsho	3789	17	,	,	,
cord-006229-7yoilsho	3789	18	cell	cell	NN
cord-006229-7yoilsho	3789	19	cycle	cycle	NN
cord-006229-7yoilsho	3789	20	regulation	regulation	NN
cord-006229-7yoilsho	3789	21	and	and	CC
cord-006229-7yoilsho	3789	22	cell	cell	NN
cord-006229-7yoilsho	3789	23	death	death	NN
cord-006229-7yoilsho	3789	24	are	be	VBP
cord-006229-7yoilsho	3789	25	regulated	regulate	VBN
cord-006229-7yoilsho	3789	26	by	by	IN
cord-006229-7yoilsho	3789	27	the	the	DT
cord-006229-7yoilsho	3789	28	four	four	CD
cord-006229-7yoilsho	3789	29	structurally	structurally	RB
cord-006229-7yoilsho	3789	30	different	different	JJ
cord-006229-7yoilsho	3789	31	PA	PA	NNP
cord-006229-7yoilsho	3789	32	echimidine	echimidine	NN
cord-006229-7yoilsho	3789	33	,	,	,
cord-006229-7yoilsho	3789	34	heliotrine	heliotrine	NN
cord-006229-7yoilsho	3789	35	,	,	,
cord-006229-7yoilsho	3789	36	senecionine	senecionine	NN
cord-006229-7yoilsho	3789	37	and	and	CC
cord-006229-7yoilsho	3789	38	senkirkine	senkirkine	NN
cord-006229-7yoilsho	3789	39	in	in	IN
cord-006229-7yoilsho	3789	40	short	short	JJ
cord-006229-7yoilsho	3789	41	-	-	HYPH
cord-006229-7yoilsho	3789	42	term	term	NN
cord-006229-7yoilsho	3789	43	exposure	exposure	NN
cord-006229-7yoilsho	3789	44	(	(	-LRB-
cord-006229-7yoilsho	3789	45	24h	24h	CD
cord-006229-7yoilsho	3789	46	)	)	-RRB-
cord-006229-7yoilsho	3789	47	.	.	.
cord-006229-7yoilsho	3790	1	Additionally	additionally	RB
cord-006229-7yoilsho	3790	2	,	,	,
cord-006229-7yoilsho	3790	3	lipid	lipid	NN
cord-006229-7yoilsho	3790	4	and	and	CC
cord-006229-7yoilsho	3790	5	bile	bile	NN
cord-006229-7yoilsho	3790	6	acid	acid	NN
cord-006229-7yoilsho	3790	7	metabolism	metabolism	NN
cord-006229-7yoilsho	3790	8	was	be	VBD
cord-006229-7yoilsho	3790	9	affected	affect	VBN
cord-006229-7yoilsho	3790	10	.	.	.
cord-006229-7yoilsho	3791	1	However	however	RB
cord-006229-7yoilsho	3791	2	,	,	,
cord-006229-7yoilsho	3791	3	the	the	DT
cord-006229-7yoilsho	3791	4	uptake	uptake	NN
cord-006229-7yoilsho	3791	5	of	of	IN
cord-006229-7yoilsho	3791	6	PA	PA	NNP
cord-006229-7yoilsho	3791	7	by	by	IN
cord-006229-7yoilsho	3791	8	food	food	NN
cord-006229-7yoilsho	3791	9	is	be	VBZ
cord-006229-7yoilsho	3791	10	more	more	RBR
cord-006229-7yoilsho	3791	11	likely	likely	JJ
cord-006229-7yoilsho	3791	12	to	to	TO
cord-006229-7yoilsho	3791	13	be	be	VB
cord-006229-7yoilsho	3791	14	continuous	continuous	JJ
cord-006229-7yoilsho	3791	15	than	than	IN
cord-006229-7yoilsho	3791	16	singular	singular	JJ
cord-006229-7yoilsho	3791	17	.	.	.
cord-006229-7yoilsho	3792	1	Therefore	therefore	RB
cord-006229-7yoilsho	3792	2	,	,	,
cord-006229-7yoilsho	3792	3	the	the	DT
cord-006229-7yoilsho	3792	4	aim	aim	NN
cord-006229-7yoilsho	3792	5	of	of	IN
cord-006229-7yoilsho	3792	6	this	this	DT
cord-006229-7yoilsho	3792	7	study	study	NN
cord-006229-7yoilsho	3792	8	was	be	VBD
cord-006229-7yoilsho	3792	9	to	to	TO
cord-006229-7yoilsho	3792	10	investigate	investigate	VB
cord-006229-7yoilsho	3792	11	molecular	molecular	JJ
cord-006229-7yoilsho	3792	12	effects	effect	NNS
cord-006229-7yoilsho	3792	13	of	of	IN
cord-006229-7yoilsho	3792	14	longterm	longterm	JJ
cord-006229-7yoilsho	3792	15	exposure	exposure	NN
cord-006229-7yoilsho	3792	16	(	(	-LRB-
cord-006229-7yoilsho	3792	17	14d	14d	CD
cord-006229-7yoilsho	3792	18	)	)	-RRB-
cord-006229-7yoilsho	3793	1	comparatively	comparatively	RB
cord-006229-7yoilsho	3793	2	to	to	IN
cord-006229-7yoilsho	3793	3	short	short	JJ
cord-006229-7yoilsho	3793	4	-	-	HYPH
cord-006229-7yoilsho	3793	5	term	term	NN
cord-006229-7yoilsho	3793	6	exposure	exposure	NN
cord-006229-7yoilsho	3793	7	(	(	-LRB-
cord-006229-7yoilsho	3793	8	24h	24h	CD
cord-006229-7yoilsho	3793	9	)	)	-RRB-
cord-006229-7yoilsho	3793	10	in	in	IN
cord-006229-7yoilsho	3793	11	the	the	DT
cord-006229-7yoilsho	3793	12	hepatoma	hepatoma	NNP
cord-006229-7yoilsho	3793	13	cell	cell	NN
cord-006229-7yoilsho	3793	14	line	line	NN
cord-006229-7yoilsho	3793	15	HepaRG	HepaRG	NNP
cord-006229-7yoilsho	3793	16	with	with	IN
cord-006229-7yoilsho	3793	17	the	the	DT
cord-006229-7yoilsho	3793	18	four	four	CD
cord-006229-7yoilsho	3793	19	structurally	structurally	RB
cord-006229-7yoilsho	3793	20	different	different	JJ
cord-006229-7yoilsho	3793	21	PA	PA	NNP
cord-006229-7yoilsho	3793	22	.	.	.
cord-006229-7yoilsho	3794	1	In	in	IN
cord-006229-7yoilsho	3794	2	this	this	DT
cord-006229-7yoilsho	3794	3	context	context	NN
cord-006229-7yoilsho	3794	4	we	-PRON-	PRP
cord-006229-7yoilsho	3794	5	analyzed	analyze	VBD
cord-006229-7yoilsho	3794	6	selected	select	VBN
cord-006229-7yoilsho	3794	7	cellular	cellular	JJ
cord-006229-7yoilsho	3794	8	parameters	parameter	NNS
cord-006229-7yoilsho	3794	9	like	like	IN
cord-006229-7yoilsho	3794	10	cytotoxicity	cytotoxicity	NN
cord-006229-7yoilsho	3794	11	and	and	CC
cord-006229-7yoilsho	3794	12	morphology	morphology	NN
cord-006229-7yoilsho	3794	13	.	.	.
cord-006229-7yoilsho	3795	1	In	in	IN
cord-006229-7yoilsho	3795	2	contrast	contrast	NN
cord-006229-7yoilsho	3795	3	to	to	IN
cord-006229-7yoilsho	3795	4	short	short	JJ
cord-006229-7yoilsho	3795	5	-	-	HYPH
cord-006229-7yoilsho	3795	6	term	term	NN
cord-006229-7yoilsho	3795	7	exposure	exposure	NN
cord-006229-7yoilsho	3795	8	,	,	,
cord-006229-7yoilsho	3795	9	structure	structure	NN
cord-006229-7yoilsho	3795	10	-	-	HYPH
cord-006229-7yoilsho	3795	11	and	and	CC
cord-006229-7yoilsho	3795	12	concentration	concentration	NN
cord-006229-7yoilsho	3795	13	-	-	HYPH
cord-006229-7yoilsho	3795	14	dependent	dependent	JJ
cord-006229-7yoilsho	3795	15	cytotoxicity	cytotoxicity	NN
cord-006229-7yoilsho	3795	16	was	be	VBD
cord-006229-7yoilsho	3795	17	found	find	VBN
cord-006229-7yoilsho	3795	18	for	for	IN
cord-006229-7yoilsho	3795	19	the	the	DT
cord-006229-7yoilsho	3795	20	long	long	JJ
cord-006229-7yoilsho	3795	21	-	-	HYPH
cord-006229-7yoilsho	3795	22	term	term	NN
cord-006229-7yoilsho	3795	23	exposure	exposure	NN
cord-006229-7yoilsho	3795	24	(	(	-LRB-
cord-006229-7yoilsho	3796	1	Sn	Sn	NNP
cord-006229-7yoilsho	3796	2	>	>	XX
cord-006229-7yoilsho	3797	1	He	-PRON-	PRP
cord-006229-7yoilsho	3798	1	>	>	XX
cord-006229-7yoilsho	3799	1	Em	Em	NNP
cord-006229-7yoilsho	3799	2	/	/	SYM
cord-006229-7yoilsho	3799	3	Ski	Ski	NNP
cord-006229-7yoilsho	3799	4	)	)	-RRB-
cord-006229-7yoilsho	3799	5	.	.	.
cord-006229-7yoilsho	3800	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	3800	2	,	,	,
cord-006229-7yoilsho	3800	3	obvious	obvious	JJ
cord-006229-7yoilsho	3800	4	morphological	morphological	JJ
cord-006229-7yoilsho	3800	5	changes	change	NNS
cord-006229-7yoilsho	3800	6	such	such	JJ
cord-006229-7yoilsho	3800	7	as	as	IN
cord-006229-7yoilsho	3800	8	destructuration	destructuration	NN
cord-006229-7yoilsho	3800	9	and	and	CC
cord-006229-7yoilsho	3800	10	perforation	perforation	NN
cord-006229-7yoilsho	3800	11	of	of	IN
cord-006229-7yoilsho	3800	12	the	the	DT
cord-006229-7yoilsho	3800	13	HepaRG	HepaRG	NNP
cord-006229-7yoilsho	3800	14	cell	cell	NN
cord-006229-7yoilsho	3800	15	monolayer	monolayer	NN
cord-006229-7yoilsho	3800	16	were	be	VBD
cord-006229-7yoilsho	3800	17	seen	see	VBN
cord-006229-7yoilsho	3800	18	after	after	IN
cord-006229-7yoilsho	3800	19	14d	14d	NNS
cord-006229-7yoilsho	3800	20	of	of	IN
cord-006229-7yoilsho	3800	21	incubation	incubation	NN
cord-006229-7yoilsho	3800	22	.	.	.
cord-006229-7yoilsho	3801	1	Based	base	VBN
cord-006229-7yoilsho	3801	2	on	on	IN
cord-006229-7yoilsho	3801	3	these	these	DT
cord-006229-7yoilsho	3801	4	findings	finding	NNS
cord-006229-7yoilsho	3801	5	,	,	,
cord-006229-7yoilsho	3801	6	a	a	DT
cord-006229-7yoilsho	3801	7	possible	possible	JJ
cord-006229-7yoilsho	3801	8	induction	induction	NN
cord-006229-7yoilsho	3801	9	of	of	IN
cord-006229-7yoilsho	3801	10	apoptosis	apoptosis	NN
cord-006229-7yoilsho	3801	11	or	or	CC
cord-006229-7yoilsho	3801	12	necrosis	necrosis	NN
cord-006229-7yoilsho	3801	13	by	by	IN
cord-006229-7yoilsho	3801	14	PA	PA	NNP
cord-006229-7yoilsho	3801	15	was	be	VBD
cord-006229-7yoilsho	3801	16	examined	examine	VBN
cord-006229-7yoilsho	3801	17	.	.	.
cord-006229-7yoilsho	3802	1	Effects	effect	NNS
cord-006229-7yoilsho	3802	2	of	of	IN
cord-006229-7yoilsho	3802	3	long	long	JJ
cord-006229-7yoilsho	3802	4	-	-	HYPH
cord-006229-7yoilsho	3802	5	term	term	NN
cord-006229-7yoilsho	3802	6	exposure	exposure	NN
cord-006229-7yoilsho	3802	7	to	to	IN
cord-006229-7yoilsho	3802	8	PA	PA	NNP
cord-006229-7yoilsho	3802	9	on	on	IN
cord-006229-7yoilsho	3802	10	gene	gene	NN
cord-006229-7yoilsho	3802	11	expression	expression	NN
cord-006229-7yoilsho	3802	12	were	be	VBD
cord-006229-7yoilsho	3802	13	investigated	investigate	VBN
cord-006229-7yoilsho	3802	14	for	for	IN
cord-006229-7yoilsho	3802	15	a	a	DT
cord-006229-7yoilsho	3802	16	set	set	NN
cord-006229-7yoilsho	3802	17	of	of	IN
cord-006229-7yoilsho	3802	18	genes	gene	NNS
cord-006229-7yoilsho	3802	19	found	find	VBN
cord-006229-7yoilsho	3802	20	to	to	TO
cord-006229-7yoilsho	3802	21	be	be	VB
cord-006229-7yoilsho	3802	22	regulated	regulate	VBN
cord-006229-7yoilsho	3802	23	in	in	IN
cord-006229-7yoilsho	3802	24	the	the	DT
cord-006229-7yoilsho	3802	25	short	short	JJ
cord-006229-7yoilsho	3802	26	-	-	HYPH
cord-006229-7yoilsho	3802	27	term	term	NN
cord-006229-7yoilsho	3802	28	whole	whole	JJ
cord-006229-7yoilsho	3802	29	genome	genome	NN
cord-006229-7yoilsho	3802	30	transcriptome	transcriptome	NN
cord-006229-7yoilsho	3802	31	study	study	NN
cord-006229-7yoilsho	3802	32	.	.	.
cord-006229-7yoilsho	3803	1	The	the	DT
cord-006229-7yoilsho	3803	2	identified	identify	VBN
cord-006229-7yoilsho	3803	3	regulation	regulation	NN
cord-006229-7yoilsho	3803	4	of	of	IN
cord-006229-7yoilsho	3803	5	gene	gene	NN
cord-006229-7yoilsho	3803	6	expression	expression	NN
cord-006229-7yoilsho	3803	7	was	be	VBD
cord-006229-7yoilsho	3803	8	confirmed	confirm	VBN
cord-006229-7yoilsho	3803	9	for	for	IN
cord-006229-7yoilsho	3803	10	both	both	DT
cord-006229-7yoilsho	3803	11	terms	term	NNS
cord-006229-7yoilsho	3803	12	,	,	,
cord-006229-7yoilsho	3803	13	with	with	IN
cord-006229-7yoilsho	3803	14	the	the	DT
cord-006229-7yoilsho	3803	15	strongest	strong	JJS
cord-006229-7yoilsho	3803	16	regulation	regulation	NN
cord-006229-7yoilsho	3803	17	for	for	IN
cord-006229-7yoilsho	3803	18	CYP7A1	CYP7A1	NNP
cord-006229-7yoilsho	3803	19	(	(	-LRB-
cord-006229-7yoilsho	3803	20	down	down	IN
cord-006229-7yoilsho	3803	21	-	-	HYPH
cord-006229-7yoilsho	3803	22	regulation	regulation	NN
cord-006229-7yoilsho	3803	23	)	)	-RRB-
cord-006229-7yoilsho	3803	24	,	,	,
cord-006229-7yoilsho	3803	25	a	a	DT
cord-006229-7yoilsho	3803	26	gene	gene	NN
cord-006229-7yoilsho	3803	27	involved	involve	VBN
cord-006229-7yoilsho	3803	28	in	in	IN
cord-006229-7yoilsho	3803	29	cholesterol	cholesterol	NN
cord-006229-7yoilsho	3803	30	metabolism	metabolism	NN
cord-006229-7yoilsho	3803	31	.	.	.
cord-006229-7yoilsho	3804	1	Therefore	therefore	RB
cord-006229-7yoilsho	3804	2	,	,	,
cord-006229-7yoilsho	3804	3	the	the	DT
cord-006229-7yoilsho	3804	4	effects	effect	NNS
cord-006229-7yoilsho	3804	5	of	of	IN
cord-006229-7yoilsho	3804	6	PA	PA	NNP
cord-006229-7yoilsho	3804	7	on	on	IN
cord-006229-7yoilsho	3804	8	various	various	JJ
cord-006229-7yoilsho	3804	9	parameters	parameter	NNS
cord-006229-7yoilsho	3804	10	related	relate	VBN
cord-006229-7yoilsho	3804	11	to	to	IN
cord-006229-7yoilsho	3804	12	cholesterol	cholesterol	NN
cord-006229-7yoilsho	3804	13	metabolism	metabolism	NN
cord-006229-7yoilsho	3804	14	were	be	VBD
cord-006229-7yoilsho	3804	15	analyzed	analyze	VBN
cord-006229-7yoilsho	3804	16	,	,	,
cord-006229-7yoilsho	3804	17	showing	show	VBG
cord-006229-7yoilsho	3804	18	PA	PA	NNP
cord-006229-7yoilsho	3804	19	effects	effect	NNS
cord-006229-7yoilsho	3804	20	on	on	IN
cord-006229-7yoilsho	3804	21	cholesterol	cholesterol	NN
cord-006229-7yoilsho	3804	22	levels	level	NNS
cord-006229-7yoilsho	3804	23	and	and	CC
cord-006229-7yoilsho	3804	24	bile	bile	NN
cord-006229-7yoilsho	3804	25	acid	acid	NN
cord-006229-7yoilsho	3804	26	secretion	secretion	NN
cord-006229-7yoilsho	3804	27	.	.	.
cord-006229-7yoilsho	3805	1	Short	short	JJ
cord-006229-7yoilsho	3805	2	-	-	HYPH
cord-006229-7yoilsho	3805	3	term	term	NN
cord-006229-7yoilsho	3805	4	exposure	exposure	NN
cord-006229-7yoilsho	3805	5	to	to	IN
cord-006229-7yoilsho	3805	6	PA	PA	NNP
cord-006229-7yoilsho	3805	7	did	do	VBD
cord-006229-7yoilsho	3805	8	not	not	RB
cord-006229-7yoilsho	3805	9	affect	affect	VB
cord-006229-7yoilsho	3805	10	cell	cell	NN
cord-006229-7yoilsho	3805	11	viability	viability	NN
cord-006229-7yoilsho	3805	12	.	.	.
cord-006229-7yoilsho	3806	1	However	however	RB
cord-006229-7yoilsho	3806	2	,	,	,
cord-006229-7yoilsho	3806	3	repeated	repeat	VBN
cord-006229-7yoilsho	3806	4	doses	dose	NNS
cord-006229-7yoilsho	3806	5	of	of	IN
cord-006229-7yoilsho	3806	6	PA	PA	NNP
cord-006229-7yoilsho	3806	7	resulted	result	VBD
cord-006229-7yoilsho	3806	8	in	in	IN
cord-006229-7yoilsho	3806	9	severe	severe	JJ
cord-006229-7yoilsho	3806	10	effects	effect	NNS
cord-006229-7yoilsho	3806	11	on	on	IN
cord-006229-7yoilsho	3806	12	hepatic	hepatic	JJ
cord-006229-7yoilsho	3806	13	cells	cell	NNS
cord-006229-7yoilsho	3806	14	,	,	,
cord-006229-7yoilsho	3806	15	concerning	concern	VBG
cord-006229-7yoilsho	3806	16	viability	viability	NN
cord-006229-7yoilsho	3806	17	and	and	CC
cord-006229-7yoilsho	3806	18	morphology	morphology	NN
cord-006229-7yoilsho	3806	19	.	.	.
cord-006229-7yoilsho	3807	1	At	at	IN
cord-006229-7yoilsho	3807	2	the	the	DT
cord-006229-7yoilsho	3807	3	mRNA	mRNA	NNP
cord-006229-7yoilsho	3807	4	level	level	NN
cord-006229-7yoilsho	3807	5	,	,	,
cord-006229-7yoilsho	3807	6	short	short	JJ
cord-006229-7yoilsho	3807	7	-	-	HYPH
cord-006229-7yoilsho	3807	8	and	and	CC
cord-006229-7yoilsho	3807	9	long	long	JJ
cord-006229-7yoilsho	3807	10	-	-	HYPH
cord-006229-7yoilsho	3807	11	term	term	NN
cord-006229-7yoilsho	3807	12	incubation	incubation	NN
cord-006229-7yoilsho	3807	13	with	with	IN
cord-006229-7yoilsho	3807	14	PA	PA	NNP
cord-006229-7yoilsho	3807	15	seem	seem	VBP
cord-006229-7yoilsho	3807	16	to	to	TO
cord-006229-7yoilsho	3807	17	affect	affect	VB
cord-006229-7yoilsho	3807	18	a	a	DT
cord-006229-7yoilsho	3807	19	wide	wide	JJ
cord-006229-7yoilsho	3807	20	range	range	NN
cord-006229-7yoilsho	3807	21	of	of	IN
cord-006229-7yoilsho	3807	22	signaling	signal	VBG
cord-006229-7yoilsho	3807	23	pathways	pathway	NNS
cord-006229-7yoilsho	3807	24	.	.	.
cord-006229-7yoilsho	3808	1	In	in	IN
cord-006229-7yoilsho	3808	2	conclusion	conclusion	NN
cord-006229-7yoilsho	3808	3	,	,	,
cord-006229-7yoilsho	3808	4	we	-PRON-	PRP
cord-006229-7yoilsho	3808	5	show	show	VBP
cord-006229-7yoilsho	3808	6	for	for	IN
cord-006229-7yoilsho	3808	7	the	the	DT
cord-006229-7yoilsho	3808	8	first	first	JJ
cord-006229-7yoilsho	3808	9	time	time	NN
cord-006229-7yoilsho	3808	10	that	that	WDT
cord-006229-7yoilsho	3808	11	HepaRG	HepaRG	NNP
cord-006229-7yoilsho	3808	12	cells	cell	NNS
cord-006229-7yoilsho	3808	13	can	can	MD
cord-006229-7yoilsho	3808	14	serve	serve	VB
cord-006229-7yoilsho	3808	15	as	as	IN
cord-006229-7yoilsho	3808	16	an	an	DT
cord-006229-7yoilsho	3808	17	in	in	FW
cord-006229-7yoilsho	3808	18	vitro	vitro	FW
cord-006229-7yoilsho	3808	19	model	model	NN
cord-006229-7yoilsho	3808	20	for	for	IN
cord-006229-7yoilsho	3808	21	hepatotoxicity	hepatotoxicity	NN
cord-006229-7yoilsho	3808	22	following	follow	VBG
cord-006229-7yoilsho	3808	23	chronic	chronic	JJ
cord-006229-7yoilsho	3808	24	intake	intake	NN
cord-006229-7yoilsho	3808	25	of	of	IN
cord-006229-7yoilsho	3808	26	PA	PA	NNP
cord-006229-7yoilsho	3808	27	.	.	.
cord-006229-7yoilsho	3809	1	Shiga	Shiga	NNP
cord-006229-7yoilsho	3809	2	toxin	toxin	NN
cord-006229-7yoilsho	3809	3	-	-	HYPH
cord-006229-7yoilsho	3809	4	producing	produce	VBG
cord-006229-7yoilsho	3809	5	E.	E.	NNP
cord-006229-7yoilsho	3809	6	coli	coli	NNS
cord-006229-7yoilsho	3809	7	(	(	-LRB-
cord-006229-7yoilsho	3809	8	STEC	STEC	NNP
cord-006229-7yoilsho	3809	9	)	)	-RRB-
cord-006229-7yoilsho	3809	10	strains	strain	NNS
cord-006229-7yoilsho	3809	11	cause	cause	VBP
cord-006229-7yoilsho	3809	12	a	a	DT
cord-006229-7yoilsho	3809	13	diversity	diversity	NN
cord-006229-7yoilsho	3809	14	of	of	IN
cord-006229-7yoilsho	3809	15	enteric	enteric	JJ
cord-006229-7yoilsho	3809	16	symptoms	symptom	NNS
cord-006229-7yoilsho	3809	17	in	in	IN
cord-006229-7yoilsho	3809	18	humans	human	NNS
cord-006229-7yoilsho	3809	19	,	,	,
cord-006229-7yoilsho	3809	20	ranging	range	VBG
cord-006229-7yoilsho	3809	21	from	from	IN
cord-006229-7yoilsho	3809	22	mild	mild	JJ
cord-006229-7yoilsho	3809	23	diarrhea	diarrhea	NN
cord-006229-7yoilsho	3809	24	to	to	IN
cord-006229-7yoilsho	3809	25	severe	severe	JJ
cord-006229-7yoilsho	3809	26	diseases	disease	NNS
cord-006229-7yoilsho	3809	27	such	such	JJ
cord-006229-7yoilsho	3809	28	as	as	IN
cord-006229-7yoilsho	3809	29	the	the	DT
cord-006229-7yoilsho	3809	30	hemolytic	hemolytic	JJ
cord-006229-7yoilsho	3809	31	uremic	uremic	JJ
cord-006229-7yoilsho	3809	32	syndrome	syndrome	NN
cord-006229-7yoilsho	3809	33	(	(	-LRB-
cord-006229-7yoilsho	3809	34	HUS	HUS	NNP
cord-006229-7yoilsho	3809	35	)	)	-RRB-
cord-006229-7yoilsho	3809	36	.	.	.
cord-006229-7yoilsho	3810	1	HUS	HUS	NNP
cord-006229-7yoilsho	3810	2	is	be	VBZ
cord-006229-7yoilsho	3810	3	a	a	DT
cord-006229-7yoilsho	3810	4	life	life	NN
cord-006229-7yoilsho	3810	5	threatening	threaten	VBG
cord-006229-7yoilsho	3810	6	disease	disease	NN
cord-006229-7yoilsho	3810	7	with	with	IN
cord-006229-7yoilsho	3810	8	microvascular	microvascular	JJ
cord-006229-7yoilsho	3810	9	endothelial	endothelial	JJ
cord-006229-7yoilsho	3810	10	damage	damage	NN
cord-006229-7yoilsho	3810	11	in	in	IN
cord-006229-7yoilsho	3810	12	the	the	DT
cord-006229-7yoilsho	3810	13	gastrointestinal	gastrointestinal	JJ
cord-006229-7yoilsho	3810	14	tract	tract	NN
cord-006229-7yoilsho	3810	15	and	and	CC
cord-006229-7yoilsho	3810	16	the	the	DT
cord-006229-7yoilsho	3810	17	kidneys	kidney	NNS
cord-006229-7yoilsho	3810	18	,	,	,
cord-006229-7yoilsho	3810	19	which	which	WDT
cord-006229-7yoilsho	3810	20	often	often	RB
cord-006229-7yoilsho	3810	21	leads	lead	VBZ
cord-006229-7yoilsho	3810	22	to	to	IN
cord-006229-7yoilsho	3810	23	haemolytic	haemolytic	JJ
cord-006229-7yoilsho	3810	24	anemia	anemia	NN
cord-006229-7yoilsho	3810	25	,	,	,
cord-006229-7yoilsho	3810	26	thrombocytopenia	thrombocytopenia	NN
cord-006229-7yoilsho	3810	27	and	and	CC
cord-006229-7yoilsho	3810	28	acute	acute	JJ
cord-006229-7yoilsho	3810	29	renal	renal	JJ
cord-006229-7yoilsho	3810	30	failure	failure	NN
cord-006229-7yoilsho	3810	31	.	.	.
cord-006229-7yoilsho	3811	1	Shiga	Shiga	NNP
cord-006229-7yoilsho	3811	2	toxin	toxin	NN
cord-006229-7yoilsho	3811	3	plays	play	VBZ
cord-006229-7yoilsho	3811	4	a	a	DT
cord-006229-7yoilsho	3811	5	major	major	JJ
cord-006229-7yoilsho	3811	6	role	role	NN
cord-006229-7yoilsho	3811	7	for	for	IN
cord-006229-7yoilsho	3811	8	the	the	DT
cord-006229-7yoilsho	3811	9	pathogenesis	pathogenesis	NN
cord-006229-7yoilsho	3811	10	of	of	IN
cord-006229-7yoilsho	3811	11	HUS	HUS	NNP
cord-006229-7yoilsho	3811	12	but	but	CC
cord-006229-7yoilsho	3811	13	the	the	DT
cord-006229-7yoilsho	3811	14	subtilase	subtilase	NNP
cord-006229-7yoilsho	3811	15	cytotoxin	cytotoxin	NNP
cord-006229-7yoilsho	3811	16	,	,	,
cord-006229-7yoilsho	3811	17	which	which	WDT
cord-006229-7yoilsho	3811	18	was	be	VBD
cord-006229-7yoilsho	3811	19	identified	identify	VBN
cord-006229-7yoilsho	3811	20	during	during	IN
cord-006229-7yoilsho	3811	21	an	an	DT
cord-006229-7yoilsho	3811	22	HUS	HUS	NNP
cord-006229-7yoilsho	3811	23	outbreak	outbreak	NN
cord-006229-7yoilsho	3811	24	in	in	IN
cord-006229-7yoilsho	3811	25	1998	1998	CD
cord-006229-7yoilsho	3811	26	in	in	IN
cord-006229-7yoilsho	3811	27	STEC	STEC	NNP
cord-006229-7yoilsho	3811	28	strains	strain	NNS
cord-006229-7yoilsho	3811	29	,	,	,
cord-006229-7yoilsho	3811	30	might	may	MD
cord-006229-7yoilsho	3811	31	contribute	contribute	VB
cord-006229-7yoilsho	3811	32	as	as	IN
cord-006229-7yoilsho	3811	33	an	an	DT
cord-006229-7yoilsho	3811	34	additional	additional	JJ
cord-006229-7yoilsho	3811	35	potent	potent	JJ
cord-006229-7yoilsho	3811	36	enterotoxin	enterotoxin	NN
cord-006229-7yoilsho	3811	37	.	.	.
cord-006229-7yoilsho	3812	1	Like	like	IN
cord-006229-7yoilsho	3812	2	Shiga	Shiga	NNP
cord-006229-7yoilsho	3812	3	toxin	toxin	NN
cord-006229-7yoilsho	3812	4	,	,	,
cord-006229-7yoilsho	3812	5	SubAB	SubAB	NNP
cord-006229-7yoilsho	3812	6	is	be	VBZ
cord-006229-7yoilsho	3812	7	an	an	DT
cord-006229-7yoilsho	3812	8	AB	AB	NNP
cord-006229-7yoilsho	3812	9	5	5	CD
cord-006229-7yoilsho	3812	10	protein	protein	NN
cord-006229-7yoilsho	3812	11	toxin	toxin	NN
cord-006229-7yoilsho	3812	12	.	.	.
cord-006229-7yoilsho	3813	1	The	the	DT
cord-006229-7yoilsho	3813	2	pentameric	pentameric	NN
cord-006229-7yoilsho	3813	3	binding	bind	VBG
cord-006229-7yoilsho	3813	4	/	/	SYM
cord-006229-7yoilsho	3813	5	transport	transport	NN
cord-006229-7yoilsho	3813	6	subunit	subunit	NN
cord-006229-7yoilsho	3813	7	(	(	-LRB-
cord-006229-7yoilsho	3813	8	SubB	SubB	NNP
cord-006229-7yoilsho	3813	9	)	)	-RRB-
cord-006229-7yoilsho	3813	10	delivers	deliver	VBZ
cord-006229-7yoilsho	3813	11	the	the	DT
cord-006229-7yoilsho	3813	12	enzymatic	enzymatic	JJ
cord-006229-7yoilsho	3813	13	active	active	JJ
cord-006229-7yoilsho	3813	14	subunit	subunit	NN
cord-006229-7yoilsho	3813	15	(	(	-LRB-
cord-006229-7yoilsho	3813	16	SubA	SubA	NNP
cord-006229-7yoilsho	3813	17	)	)	-RRB-
cord-006229-7yoilsho	3813	18	,	,	,
cord-006229-7yoilsho	3813	19	a	a	DT
cord-006229-7yoilsho	3813	20	protease	protease	NN
cord-006229-7yoilsho	3813	21	,	,	,
cord-006229-7yoilsho	3813	22	into	into	IN
cord-006229-7yoilsho	3813	23	the	the	DT
cord-006229-7yoilsho	3813	24	endoplasmic	endoplasmic	NN
cord-006229-7yoilsho	3813	25	reticulum	reticulum	NN
cord-006229-7yoilsho	3813	26	(	(	-LRB-
cord-006229-7yoilsho	3813	27	ER	ER	NNP
cord-006229-7yoilsho	3813	28	)	)	-RRB-
cord-006229-7yoilsho	3813	29	of	of	IN
cord-006229-7yoilsho	3813	30	human	human	JJ
cord-006229-7yoilsho	3813	31	target	target	NN
cord-006229-7yoilsho	3813	32	cells	cell	NNS
cord-006229-7yoilsho	3813	33	.	.	.
cord-006229-7yoilsho	3814	1	In	in	IN
cord-006229-7yoilsho	3814	2	the	the	DT
cord-006229-7yoilsho	3814	3	ER	ER	NNP
cord-006229-7yoilsho	3814	4	,	,	,
cord-006229-7yoilsho	3814	5	SubA	SubA	NNP
cord-006229-7yoilsho	3814	6	cleaves	cleave	VBZ
cord-006229-7yoilsho	3814	7	the	the	DT
cord-006229-7yoilsho	3814	8	chaperone	chaperone	NN
cord-006229-7yoilsho	3814	9	BiP	BiP	NNP
cord-006229-7yoilsho	3814	10	/	/	,
cord-006229-7yoilsho	3814	11	GRP78	GRP78	NNP
cord-006229-7yoilsho	3814	12	,	,	,
cord-006229-7yoilsho	3814	13	which	which	WDT
cord-006229-7yoilsho	3814	14	results	result	VBZ
cord-006229-7yoilsho	3814	15	in	in	IN
cord-006229-7yoilsho	3814	16	cell	cell	NN
cord-006229-7yoilsho	3814	17	stress	stress	NN
cord-006229-7yoilsho	3814	18	and	and	CC
cord-006229-7yoilsho	3814	19	caspase	caspase	NN
cord-006229-7yoilsho	3814	20	3/7dependent	3/7dependent	CD
cord-006229-7yoilsho	3814	21	cell	cell	NN
cord-006229-7yoilsho	3814	22	death	death	NN
cord-006229-7yoilsho	3814	23	.	.	.
cord-006229-7yoilsho	3815	1	Recently	recently	RB
cord-006229-7yoilsho	3815	2	,	,	,
cord-006229-7yoilsho	3815	3	we	-PRON-	PRP
cord-006229-7yoilsho	3815	4	discovered	discover	VBD
cord-006229-7yoilsho	3815	5	that	that	IN
cord-006229-7yoilsho	3815	6	higher	high	JJR
cord-006229-7yoilsho	3815	7	concentrations	concentration	NNS
cord-006229-7yoilsho	3815	8	of	of	IN
cord-006229-7yoilsho	3815	9	SubA	SubA	NNP
cord-006229-7yoilsho	3815	10	(	(	-LRB-
cord-006229-7yoilsho	3815	11	10	10	CD
cord-006229-7yoilsho	3815	12	mg	mg	NN
cord-006229-7yoilsho	3815	13	/	/	SYM
cord-006229-7yoilsho	3815	14	mL	ml	NN
cord-006229-7yoilsho	3815	15	)	)	-RRB-
cord-006229-7yoilsho	3815	16	causes	cause	VBZ
cord-006229-7yoilsho	3815	17	cytotoxic	cytotoxic	JJ
cord-006229-7yoilsho	3815	18	effects	effect	NNS
cord-006229-7yoilsho	3815	19	in	in	IN
cord-006229-7yoilsho	3815	20	human	human	JJ
cord-006229-7yoilsho	3815	21	epithelial	epithelial	JJ
cord-006229-7yoilsho	3815	22	cells	cell	NNS
cord-006229-7yoilsho	3815	23	(	(	-LRB-
cord-006229-7yoilsho	3815	24	HeLa	HeLa	NNP
cord-006229-7yoilsho	3815	25	,	,	,
cord-006229-7yoilsho	3815	26	in	in	IN
cord-006229-7yoilsho	3815	27	the	the	DT
cord-006229-7yoilsho	3815	28	absence	absence	NN
cord-006229-7yoilsho	3815	29	of	of	IN
cord-006229-7yoilsho	3815	30	SubB.	SubB.	NNS
cord-006229-7yoilsho	3816	1	The	the	DT
cord-006229-7yoilsho	3816	2	cytotoxic	cytotoxic	JJ
cord-006229-7yoilsho	3816	3	effects	effect	NNS
cord-006229-7yoilsho	3816	4	were	be	VBD
cord-006229-7yoilsho	3816	5	investigated	investigate	VBN
cord-006229-7yoilsho	3816	6	in	in	IN
cord-006229-7yoilsho	3816	7	HeLa	HeLa	NNP
cord-006229-7yoilsho	3816	8	cells	cell	NNS
cord-006229-7yoilsho	3816	9	in	in	IN
cord-006229-7yoilsho	3816	10	more	more	JJR
cord-006229-7yoilsho	3816	11	detail	detail	NN
cord-006229-7yoilsho	3816	12	.	.	.
cord-006229-7yoilsho	3817	1	Here	here	RB
cord-006229-7yoilsho	3817	2	,	,	,
cord-006229-7yoilsho	3817	3	SubA	SubA	NNP
cord-006229-7yoilsho	3817	4	binds	bind	VBZ
cord-006229-7yoilsho	3817	5	in	in	IN
cord-006229-7yoilsho	3817	6	a	a	DT
cord-006229-7yoilsho	3817	7	concentration	concentration	NN
cord-006229-7yoilsho	3817	8	dependent	dependent	JJ
cord-006229-7yoilsho	3817	9	manner	manner	NN
cord-006229-7yoilsho	3817	10	to	to	IN
cord-006229-7yoilsho	3817	11	the	the	DT
cord-006229-7yoilsho	3817	12	cell	cell	NN
cord-006229-7yoilsho	3817	13	surface	surface	NN
cord-006229-7yoilsho	3817	14	and	and	CC
cord-006229-7yoilsho	3817	15	induces	induce	VBZ
cord-006229-7yoilsho	3817	16	dramatic	dramatic	JJ
cord-006229-7yoilsho	3817	17	morphological	morphological	JJ
cord-006229-7yoilsho	3817	18	changes	change	NNS
cord-006229-7yoilsho	3817	19	as	as	RB
cord-006229-7yoilsho	3817	20	well	well	RB
cord-006229-7yoilsho	3817	21	as	as	IN
cord-006229-7yoilsho	3817	22	caspase	caspase	NN
cord-006229-7yoilsho	3817	23	-	-	HYPH
cord-006229-7yoilsho	3817	24	dependent	dependent	JJ
cord-006229-7yoilsho	3817	25	cell	cell	NN
cord-006229-7yoilsho	3817	26	death	death	NN
cord-006229-7yoilsho	3817	27	[	[	-LRB-
cord-006229-7yoilsho	3817	28	1	1	CD
cord-006229-7yoilsho	3817	29	]	]	-RRB-
cord-006229-7yoilsho	3817	30	.	.	.
cord-006229-7yoilsho	3818	1	In	in	IN
cord-006229-7yoilsho	3818	2	contrast	contrast	NN
cord-006229-7yoilsho	3818	3	to	to	IN
cord-006229-7yoilsho	3818	4	HeLa	HeLa	NNP
cord-006229-7yoilsho	3818	5	and	and	CC
cord-006229-7yoilsho	3818	6	Caco-2	Caco-2	NNP
cord-006229-7yoilsho	3818	7	cells	cell	NNS
cord-006229-7yoilsho	3818	8	,	,	,
cord-006229-7yoilsho	3818	9	CHO	CHO	NNP
cord-006229-7yoilsho	3818	10	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	3818	11	did	do	VBD
cord-006229-7yoilsho	3818	12	not	not	RB
cord-006229-7yoilsho	3818	13	respond	respond	VB
cord-006229-7yoilsho	3818	14	to	to	IN
cord-006229-7yoilsho	3818	15	SubA.	suba.	VB
cord-006229-7yoilsho	3819	1	Currently	currently	RB
cord-006229-7yoilsho	3819	2	,	,	,
cord-006229-7yoilsho	3819	3	further	further	JJ
cord-006229-7yoilsho	3819	4	cell	cell	NN
cord-006229-7yoilsho	3819	5	types	type	NNS
cord-006229-7yoilsho	3819	6	including	include	VBG
cord-006229-7yoilsho	3819	7	macrophages	macrophage	NNS
cord-006229-7yoilsho	3819	8	are	be	VBP
cord-006229-7yoilsho	3819	9	tested	test	VBN
cord-006229-7yoilsho	3819	10	for	for	IN
cord-006229-7yoilsho	3819	11	SubA	suba	JJ
cord-006229-7yoilsho	3819	12	effects	effect	NNS
cord-006229-7yoilsho	3819	13	and	and	CC
cord-006229-7yoilsho	3819	14	the	the	DT
cord-006229-7yoilsho	3819	15	molecular	molecular	JJ
cord-006229-7yoilsho	3819	16	mechanisms	mechanism	NNS
cord-006229-7yoilsho	3819	17	underlying	underlie	VBG
cord-006229-7yoilsho	3819	18	the	the	DT
cord-006229-7yoilsho	3819	19	cytotoxic	cytotoxic	JJ
cord-006229-7yoilsho	3819	20	effects	effect	NNS
cord-006229-7yoilsho	3819	21	caused	cause	VBN
cord-006229-7yoilsho	3819	22	by	by	IN
cord-006229-7yoilsho	3819	23	SubA	SubA	NNP
cord-006229-7yoilsho	3819	24	and	and	CC
cord-006229-7yoilsho	3819	25	the	the	DT
cord-006229-7yoilsho	3819	26	cell	cell	NN
cord-006229-7yoilsho	3819	27	type	type	NN
cord-006229-7yoilsho	3819	28	selectivity	selectivity	NN
cord-006229-7yoilsho	3819	29	are	be	VBP
cord-006229-7yoilsho	3819	30	investigated	investigate	VBN
cord-006229-7yoilsho	3819	31	.	.	.
cord-006229-7yoilsho	3820	1	Although	although	IN
cord-006229-7yoilsho	3820	2	there	there	EX
cord-006229-7yoilsho	3820	3	are	be	VBP
cord-006229-7yoilsho	3820	4	strong	strong	JJ
cord-006229-7yoilsho	3820	5	cytotoxic	cytotoxic	JJ
cord-006229-7yoilsho	3820	6	effects	effect	NNS
cord-006229-7yoilsho	3820	7	caused	cause	VBN
cord-006229-7yoilsho	3820	8	by	by	IN
cord-006229-7yoilsho	3820	9	SubA	SubA	NNP
cord-006229-7yoilsho	3820	10	on	on	IN
cord-006229-7yoilsho	3820	11	some	some	DT
cord-006229-7yoilsho	3820	12	human	human	JJ
cord-006229-7yoilsho	3820	13	epithelial	epithelial	JJ
cord-006229-7yoilsho	3820	14	cells	cell	NNS
cord-006229-7yoilsho	3820	15	in	in	IN
cord-006229-7yoilsho	3820	16	vitro	vitro	FW
cord-006229-7yoilsho	3820	17	,	,	,
cord-006229-7yoilsho	3820	18	the	the	DT
cord-006229-7yoilsho	3820	19	situation	situation	NN
cord-006229-7yoilsho	3820	20	in	in	IN
cord-006229-7yoilsho	3820	21	vivo	vivo	NN
cord-006229-7yoilsho	3820	22	and	and	CC
cord-006229-7yoilsho	3820	23	the	the	DT
cord-006229-7yoilsho	3820	24	pathogenic	pathogenic	JJ
cord-006229-7yoilsho	3820	25	relevance	relevance	NN
cord-006229-7yoilsho	3820	26	of	of	IN
cord-006229-7yoilsho	3820	27	the	the	DT
cord-006229-7yoilsho	3820	28	newly	newly	RB
cord-006229-7yoilsho	3820	29	observed	observe	VBN
cord-006229-7yoilsho	3820	30	SubA	SubA	NNP
cord-006229-7yoilsho	3820	31	effect	effect	NN
cord-006229-7yoilsho	3820	32	are	be	VBP
cord-006229-7yoilsho	3820	33	not	not	RB
cord-006229-7yoilsho	3820	34	known	know	VBN
cord-006229-7yoilsho	3820	35	.	.	.
cord-006229-7yoilsho	3821	1	Thermal	thermal	JJ
cord-006229-7yoilsho	3821	2	treatment	treatment	NN
cord-006229-7yoilsho	3821	3	of	of	IN
cord-006229-7yoilsho	3821	4	fat	fat	NN
cord-006229-7yoilsho	3821	5	-	-	HYPH
cord-006229-7yoilsho	3821	6	containing	contain	VBG
cord-006229-7yoilsho	3821	7	foodstuff	foodstuff	NN
cord-006229-7yoilsho	3821	8	in	in	IN
cord-006229-7yoilsho	3821	9	the	the	DT
cord-006229-7yoilsho	3821	10	presence	presence	NN
cord-006229-7yoilsho	3821	11	of	of	IN
cord-006229-7yoilsho	3821	12	salt	salt	NN
cord-006229-7yoilsho	3821	13	leads	lead	NNS
cord-006229-7yoilsho	3821	14	to	to	IN
cord-006229-7yoilsho	3821	15	formation	formation	NN
cord-006229-7yoilsho	3821	16	of	of	IN
cord-006229-7yoilsho	3821	17	3-MCPD	3-mcpd	CD
cord-006229-7yoilsho	3821	18	and	and	CC
cord-006229-7yoilsho	3821	19	its	-PRON-	PRP$
cord-006229-7yoilsho	3821	20	esters	ester	NNS
cord-006229-7yoilsho	3821	21	.	.	.
cord-006229-7yoilsho	3822	1	High	high	JJ
cord-006229-7yoilsho	3822	2	amounts	amount	NNS
cord-006229-7yoilsho	3822	3	of	of	IN
cord-006229-7yoilsho	3822	4	3-MCPD	3-mcpd	CD
cord-006229-7yoilsho	3822	5	esters	ester	NNS
cord-006229-7yoilsho	3822	6	detected	detect	VBN
cord-006229-7yoilsho	3822	7	in	in	IN
cord-006229-7yoilsho	3822	8	food	food	NN
cord-006229-7yoilsho	3822	9	raised	raise	VBD
cord-006229-7yoilsho	3822	10	toxicological	toxicological	JJ
cord-006229-7yoilsho	3822	11	concern	concern	NN
cord-006229-7yoilsho	3822	12	.	.	.
cord-006229-7yoilsho	3823	1	Recent	recent	JJ
cord-006229-7yoilsho	3823	2	studies	study	NNS
cord-006229-7yoilsho	3823	3	revealed	reveal	VBD
cord-006229-7yoilsho	3823	4	that	that	IN
cord-006229-7yoilsho	3823	5	food	food	NN
cord-006229-7yoilsho	3823	6	may	may	MD
cord-006229-7yoilsho	3823	7	also	also	RB
cord-006229-7yoilsho	3823	8	contain	contain	VB
cord-006229-7yoilsho	3823	9	significant	significant	JJ
cord-006229-7yoilsho	3823	10	amounts	amount	NNS
cord-006229-7yoilsho	3823	11	of	of	IN
cord-006229-7yoilsho	3823	12	structurally	structurally	RB
cord-006229-7yoilsho	3823	13	related	relate	VBN
cord-006229-7yoilsho	3823	14	2-MCPD	2-mcpd	CD
cord-006229-7yoilsho	3823	15	and	and	CC
cord-006229-7yoilsho	3823	16	its	-PRON-	PRP$
cord-006229-7yoilsho	3823	17	fatty	fatty	JJ
cord-006229-7yoilsho	3823	18	acid	acid	NN
cord-006229-7yoilsho	3823	19	esters	ester	NNS
cord-006229-7yoilsho	3823	20	.	.	.
cord-006229-7yoilsho	3824	1	Toxicological	toxicological	JJ
cord-006229-7yoilsho	3824	2	studies	study	NNS
cord-006229-7yoilsho	3824	3	indicate	indicate	VBP
cord-006229-7yoilsho	3824	4	genotoxicity	genotoxicity	NN
cord-006229-7yoilsho	3824	5	in	in	IN
cord-006229-7yoilsho	3824	6	vitro	vitro	FW
cord-006229-7yoilsho	3824	7	and	and	CC
cord-006229-7yoilsho	3824	8	a	a	DT
cord-006229-7yoilsho	3824	9	carcinogenic	carcinogenic	JJ
cord-006229-7yoilsho	3824	10	potential	potential	NN
cord-006229-7yoilsho	3824	11	of	of	IN
cord-006229-7yoilsho	3824	12	3-MCPD	3-mcpd	CD
cord-006229-7yoilsho	3824	13	,	,	,
cord-006229-7yoilsho	3824	14	pointing	point	VBG
cord-006229-7yoilsho	3824	15	to	to	IN
cord-006229-7yoilsho	3824	16	kidney	kidney	NN
cord-006229-7yoilsho	3824	17	and	and	CC
cord-006229-7yoilsho	3824	18	testes	testis	NNS
cord-006229-7yoilsho	3824	19	as	as	IN
cord-006229-7yoilsho	3824	20	main	main	JJ
cord-006229-7yoilsho	3824	21	target	target	NN
cord-006229-7yoilsho	3824	22	organs	organ	NNS
cord-006229-7yoilsho	3824	23	.	.	.
cord-006229-7yoilsho	3825	1	3-MCPD	3-mcpd	CD
cord-006229-7yoilsho	3825	2	esters	ester	NNS
cord-006229-7yoilsho	3825	3	were	be	VBD
cord-006229-7yoilsho	3825	4	shown	show	VBN
cord-006229-7yoilsho	3825	5	to	to	TO
cord-006229-7yoilsho	3825	6	cause	cause	VB
cord-006229-7yoilsho	3825	7	similar	similar	JJ
cord-006229-7yoilsho	3825	8	,	,	,
cord-006229-7yoilsho	3825	9	but	but	CC
cord-006229-7yoilsho	3825	10	milder	mild	JJR
cord-006229-7yoilsho	3825	11	effects	effect	NNS
cord-006229-7yoilsho	3825	12	.	.	.
cord-006229-7yoilsho	3826	1	Few	few	JJ
cord-006229-7yoilsho	3826	2	unpublished	unpublished	JJ
cord-006229-7yoilsho	3826	3	data	datum	NNS
cord-006229-7yoilsho	3826	4	exist	exist	VBP
cord-006229-7yoilsho	3826	5	for	for	IN
cord-006229-7yoilsho	3826	6	2-MCPD	2-mcpd	CD
cord-006229-7yoilsho	3826	7	,	,	,
cord-006229-7yoilsho	3826	8	showing	show	VBG
cord-006229-7yoilsho	3826	9	similar	similar	JJ
cord-006229-7yoilsho	3826	10	organ	organ	NN
cord-006229-7yoilsho	3826	11	toxicity	toxicity	NN
cord-006229-7yoilsho	3826	12	compared	compare	VBN
cord-006229-7yoilsho	3826	13	to	to	IN
cord-006229-7yoilsho	3826	14	3-MCPD	3-mcpd	CD
cord-006229-7yoilsho	3826	15	and	and	CC
cord-006229-7yoilsho	3826	16	identifying	identify	VBG
cord-006229-7yoilsho	3826	17	heart	heart	NN
cord-006229-7yoilsho	3826	18	as	as	IN
cord-006229-7yoilsho	3826	19	additional	additional	JJ
cord-006229-7yoilsho	3826	20	target	target	NN
cord-006229-7yoilsho	3826	21	organ	organ	NN
cord-006229-7yoilsho	3826	22	.	.	.
cord-006229-7yoilsho	3827	1	No	no	DT
cord-006229-7yoilsho	3827	2	such	such	JJ
cord-006229-7yoilsho	3827	3	data	datum	NNS
cord-006229-7yoilsho	3827	4	exist	exist	VBP
cord-006229-7yoilsho	3827	5	for	for	IN
cord-006229-7yoilsho	3827	6	2-MCPD	2-mcpd	CD
cord-006229-7yoilsho	3827	7	diesters	diester	NNS
cord-006229-7yoilsho	3827	8	.	.	.
cord-006229-7yoilsho	3828	1	In	in	IN
cord-006229-7yoilsho	3828	2	consequence	consequence	NN
cord-006229-7yoilsho	3828	3	,	,	,
cord-006229-7yoilsho	3828	4	further	further	JJ
cord-006229-7yoilsho	3828	5	toxicological	toxicological	JJ
cord-006229-7yoilsho	3828	6	data	datum	NNS
cord-006229-7yoilsho	3828	7	were	be	VBD
cord-006229-7yoilsho	3828	8	required	require	VBN
cord-006229-7yoilsho	3828	9	in	in	IN
cord-006229-7yoilsho	3828	10	order	order	NN
cord-006229-7yoilsho	3828	11	to	to	TO
cord-006229-7yoilsho	3828	12	complete	complete	VB
cord-006229-7yoilsho	3828	13	risk	risk	NN
cord-006229-7yoilsho	3828	14	assessment	assessment	NN
cord-006229-7yoilsho	3828	15	for	for	IN
cord-006229-7yoilsho	3828	16	3-MCPD	3-mcpd	CD
cord-006229-7yoilsho	3828	17	,	,	,
cord-006229-7yoilsho	3828	18	2-MCPD	2-mcpd	CD
cord-006229-7yoilsho	3828	19	and	and	CC
cord-006229-7yoilsho	3828	20	their	-PRON-	PRP$
cord-006229-7yoilsho	3828	21	esters	ester	NNS
cord-006229-7yoilsho	3828	22	.	.	.
cord-006229-7yoilsho	3829	1	Hence	hence	RB
cord-006229-7yoilsho	3829	2	,	,	,
cord-006229-7yoilsho	3829	3	an	an	DT
cord-006229-7yoilsho	3829	4	oral	oral	JJ
cord-006229-7yoilsho	3829	5	28-days	28-days	CD
cord-006229-7yoilsho	3829	6	study	study	NN
cord-006229-7yoilsho	3829	7	was	be	VBD
cord-006229-7yoilsho	3829	8	performed	perform	VBN
cord-006229-7yoilsho	3829	9	in	in	IN
cord-006229-7yoilsho	3829	10	male	male	JJ
cord-006229-7yoilsho	3829	11	rats	rat	NNS
cord-006229-7yoilsho	3829	12	in	in	IN
cord-006229-7yoilsho	3829	13	order	order	NN
cord-006229-7yoilsho	3829	14	to	to	TO
cord-006229-7yoilsho	3829	15	fill	fill	VB
cord-006229-7yoilsho	3829	16	data	data	NN
cord-006229-7yoilsho	3829	17	gaps	gap	NNS
cord-006229-7yoilsho	3829	18	and	and	CC
cord-006229-7yoilsho	3829	19	provide	provide	VB
cord-006229-7yoilsho	3829	20	essential	essential	JJ
cord-006229-7yoilsho	3829	21	information	information	NN
cord-006229-7yoilsho	3829	22	for	for	IN
cord-006229-7yoilsho	3829	23	risk	risk	NN
cord-006229-7yoilsho	3829	24	assessment	assessment	NN
cord-006229-7yoilsho	3829	25	.	.	.
cord-006229-7yoilsho	3830	1	A	a	DT
cord-006229-7yoilsho	3830	2	proteomic	proteomic	JJ
cord-006229-7yoilsho	3830	3	analysis	analysis	NN
cord-006229-7yoilsho	3830	4	was	be	VBD
cord-006229-7yoilsho	3830	5	included	include	VBN
cord-006229-7yoilsho	3830	6	in	in	IN
cord-006229-7yoilsho	3830	7	order	order	NN
cord-006229-7yoilsho	3830	8	to	to	TO
cord-006229-7yoilsho	3830	9	compare	compare	VB
cord-006229-7yoilsho	3830	10	molecular	molecular	JJ
cord-006229-7yoilsho	3830	11	effects	effect	NNS
cord-006229-7yoilsho	3830	12	induced	induce	VBN
cord-006229-7yoilsho	3830	13	by	by	IN
cord-006229-7yoilsho	3830	14	3-MCPD	3-mcpd	CD
cord-006229-7yoilsho	3830	15	and	and	CC
cord-006229-7yoilsho	3830	16	2-MCPD	2-mcpd	CD
cord-006229-7yoilsho	3830	17	and	and	CC
cord-006229-7yoilsho	3830	18	its	-PRON-	PRP$
cord-006229-7yoilsho	3830	19	dipalmitic	dipalmitic	JJ
cord-006229-7yoilsho	3830	20	ester	ester	NN
cord-006229-7yoilsho	3830	21	in	in	IN
cord-006229-7yoilsho	3830	22	rat	rat	NN
cord-006229-7yoilsho	3830	23	liver	liver	NN
cord-006229-7yoilsho	3830	24	,	,	,
cord-006229-7yoilsho	3830	25	kidney	kidney	NN
cord-006229-7yoilsho	3830	26	,	,	,
cord-006229-7yoilsho	3830	27	testes	testis	NNS
cord-006229-7yoilsho	3830	28	and	and	CC
cord-006229-7yoilsho	3830	29	heart	heart	NN
cord-006229-7yoilsho	3830	30	.	.	.
cord-006229-7yoilsho	3831	1	In	in	IN
cord-006229-7yoilsho	3831	2	order	order	NN
cord-006229-7yoilsho	3831	3	to	to	TO
cord-006229-7yoilsho	3831	4	avoid	avoid	VB
cord-006229-7yoilsho	3831	5	overt	overt	JJ
cord-006229-7yoilsho	3831	6	toxicity	toxicity	NN
cord-006229-7yoilsho	3831	7	,	,	,
cord-006229-7yoilsho	3831	8	moderate	moderate	JJ
cord-006229-7yoilsho	3831	9	doses	dose	NNS
cord-006229-7yoilsho	3831	10	of	of	IN
cord-006229-7yoilsho	3831	11	3-MCPD	3-mcpd	CD
cord-006229-7yoilsho	3831	12	+	+	SYM
cord-006229-7yoilsho	3831	13	2-MCPD	2-mcpd	CD
cord-006229-7yoilsho	3832	1	(	(	-LRB-
cord-006229-7yoilsho	3832	2	10	10	CD
cord-006229-7yoilsho	3832	3	mg	mg	NNP
cord-006229-7yoilsho	3832	4	/	/	SYM
cord-006229-7yoilsho	3832	5	kg	kg	NN
cord-006229-7yoilsho	3832	6	body	body	NN
cord-006229-7yoilsho	3832	7	weight	weight	NN
cord-006229-7yoilsho	3832	8	)	)	-RRB-
cord-006229-7yoilsho	3832	9	,	,	,
cord-006229-7yoilsho	3832	10	and	and	CC
cord-006229-7yoilsho	3832	11	2-MCPD	2-mcpd	CD
cord-006229-7yoilsho	3832	12	-	-	HYPH
cord-006229-7yoilsho	3832	13	dipalmitate	dipalmitate	NN
cord-006229-7yoilsho	3832	14	(	(	-LRB-
cord-006229-7yoilsho	3832	15	53	53	CD
cord-006229-7yoilsho	3832	16	+	+	SYM
cord-006229-7yoilsho	3832	17	13.3	13.3	CD
cord-006229-7yoilsho	3832	18	mg	mg	NNP
cord-006229-7yoilsho	3832	19	/	/	SYM
cord-006229-7yoilsho	3832	20	kg	kg	NNP
cord-006229-7yoilsho	3832	21	body	body	NN
cord-006229-7yoilsho	3832	22	weight	weight	NN
cord-006229-7yoilsho	3832	23	)	)	-RRB-
cord-006229-7yoilsho	3832	24	were	be	VBD
cord-006229-7yoilsho	3832	25	applied	apply	VBN
cord-006229-7yoilsho	3832	26	.	.	.
cord-006229-7yoilsho	3833	1	Accordingly	accordingly	RB
cord-006229-7yoilsho	3833	2	,	,	,
cord-006229-7yoilsho	3833	3	no	no	DT
cord-006229-7yoilsho	3833	4	pathologic	pathologic	JJ
cord-006229-7yoilsho	3833	5	effects	effect	NNS
cord-006229-7yoilsho	3833	6	were	be	VBD
cord-006229-7yoilsho	3833	7	reported	report	VBN
cord-006229-7yoilsho	3833	8	.	.	.
cord-006229-7yoilsho	3834	1	Here	here	RB
cord-006229-7yoilsho	3834	2	,	,	,
cord-006229-7yoilsho	3834	3	we	-PRON-	PRP
cord-006229-7yoilsho	3834	4	present	present	VBP
cord-006229-7yoilsho	3834	5	proteomic	proteomic	JJ
cord-006229-7yoilsho	3834	6	results	result	NNS
cord-006229-7yoilsho	3834	7	obtained	obtain	VBN
cord-006229-7yoilsho	3834	8	after	after	IN
cord-006229-7yoilsho	3834	9	analysis	analysis	NN
cord-006229-7yoilsho	3834	10	of	of	IN
cord-006229-7yoilsho	3834	11	heart	heart	NN
cord-006229-7yoilsho	3834	12	tissue	tissue	NN
cord-006229-7yoilsho	3834	13	.	.	.
cord-006229-7yoilsho	3835	1	After	after	IN
cord-006229-7yoilsho	3835	2	separation	separation	NN
cord-006229-7yoilsho	3835	3	of	of	IN
cord-006229-7yoilsho	3835	4	heart	heart	NN
cord-006229-7yoilsho	3835	5	tissue	tissue	NN
cord-006229-7yoilsho	3835	6	protein	protein	NN
cord-006229-7yoilsho	3835	7	crude	crude	NN
cord-006229-7yoilsho	3835	8	extract	extract	NN
cord-006229-7yoilsho	3835	9	by	by	IN
cord-006229-7yoilsho	3835	10	2-D	2-D	NNP
cord-006229-7yoilsho	3835	11	gel	gel	NN
cord-006229-7yoilsho	3835	12	electrophoresis	electrophoresis	NN
cord-006229-7yoilsho	3835	13	,	,	,
cord-006229-7yoilsho	3835	14	differentially	differentially	RB
cord-006229-7yoilsho	3835	15	expressed	express	VBN
cord-006229-7yoilsho	3835	16	spots	spot	NNS
cord-006229-7yoilsho	3835	17	were	be	VBD
cord-006229-7yoilsho	3835	18	identified	identify	VBN
cord-006229-7yoilsho	3835	19	by	by	IN
cord-006229-7yoilsho	3835	20	MALDI	MALDI	NNP
cord-006229-7yoilsho	3835	21	-	-	HYPH
cord-006229-7yoilsho	3835	22	MS	MS	NNP
cord-006229-7yoilsho	3835	23	.	.	.
cord-006229-7yoilsho	3836	1	A	a	DT
cord-006229-7yoilsho	3836	2	total	total	NN
cord-006229-7yoilsho	3836	3	of	of	IN
cord-006229-7yoilsho	3836	4	270	270	CD
cord-006229-7yoilsho	3836	5	unique	unique	JJ
cord-006229-7yoilsho	3836	6	proteins	protein	NNS
cord-006229-7yoilsho	3836	7	deregulated	deregulate	VBN
cord-006229-7yoilsho	3836	8	at	at	IN
cord-006229-7yoilsho	3836	9	a	a	DT
cord-006229-7yoilsho	3836	10	log	log	NN
cord-006229-7yoilsho	3836	11	2	2	CD
cord-006229-7yoilsho	3836	12	ratio	ratio	NN
cord-006229-7yoilsho	3836	13	of	of	IN
cord-006229-7yoilsho	3836	14	≤	≤	NN
cord-006229-7yoilsho	3836	15	-0.5	-0.5	XX
cord-006229-7yoilsho	3836	16	for	for	IN
cord-006229-7yoilsho	3836	17	downregulation	downregulation	NN
cord-006229-7yoilsho	3836	18	and	and	CC
cord-006229-7yoilsho	3836	19	≥	≥	CD
cord-006229-7yoilsho	3836	20	0.5	0.5	CD
cord-006229-7yoilsho	3836	21	for	for	IN
cord-006229-7yoilsho	3836	22	upregulation	upregulation	NN
cord-006229-7yoilsho	3836	23	at	at	IN
cord-006229-7yoilsho	3836	24	p	p	NN
cord-006229-7yoilsho	3836	25	≤	≤	NN
cord-006229-7yoilsho	3836	26	0.05	0.05	CD
cord-006229-7yoilsho	3836	27	were	be	VBD
cord-006229-7yoilsho	3836	28	identified	identify	VBN
cord-006229-7yoilsho	3836	29	.	.	.
cord-006229-7yoilsho	3837	1	Comparing	compare	VBG
cord-006229-7yoilsho	3837	2	deregulated	deregulate	VBN
cord-006229-7yoilsho	3837	3	spots	spot	NNS
cord-006229-7yoilsho	3837	4	induced	induce	VBN
cord-006229-7yoilsho	3837	5	by	by	IN
cord-006229-7yoilsho	3837	6	different	different	JJ
cord-006229-7yoilsho	3837	7	treatments	treatment	NNS
cord-006229-7yoilsho	3837	8	revealed	reveal	VBD
cord-006229-7yoilsho	3837	9	that	that	IN
cord-006229-7yoilsho	3837	10	a	a	DT
cord-006229-7yoilsho	3837	11	higher	high	JJR
cord-006229-7yoilsho	3837	12	number	number	NN
cord-006229-7yoilsho	3837	13	of	of	IN
cord-006229-7yoilsho	3837	14	spots	spot	NNS
cord-006229-7yoilsho	3837	15	was	be	VBD
cord-006229-7yoilsho	3837	16	deregulated	deregulate	VBN
cord-006229-7yoilsho	3837	17	by	by	IN
cord-006229-7yoilsho	3837	18	2-MCPD	2-mcpd	CD
cord-006229-7yoilsho	3837	19	versus	versus	IN
cord-006229-7yoilsho	3837	20	3-MCPD	3-mcpd	CD
cord-006229-7yoilsho	3837	21	.	.	.
cord-006229-7yoilsho	3838	1	Dipalmitate	dipalmitate	NN
cord-006229-7yoilsho	3838	2	treatment	treatment	NN
cord-006229-7yoilsho	3838	3	even	even	RB
cord-006229-7yoilsho	3838	4	caused	cause	VBD
cord-006229-7yoilsho	3838	5	more	more	JJR
cord-006229-7yoilsho	3838	6	deregulation	deregulation	NN
cord-006229-7yoilsho	3838	7	than	than	IN
cord-006229-7yoilsho	3838	8	2-MCPD	2-mcpd	CD
cord-006229-7yoilsho	3838	9	.	.	.
cord-006229-7yoilsho	3839	1	Upregulated	Upregulated	NNP
cord-006229-7yoilsho	3839	2	cytochrome	cytochrome	NN
cord-006229-7yoilsho	3839	3	b	b	NN
cord-006229-7yoilsho	3839	4	-	-	HYPH
cord-006229-7yoilsho	3839	5	c1	c1	NN
cord-006229-7yoilsho	3839	6	complex	complex	JJ
cord-006229-7yoilsho	3839	7	subunit	subunit	NN
cord-006229-7yoilsho	3839	8	Rieske	Rieske	NNP
cord-006229-7yoilsho	3839	9	(	(	-LRB-
cord-006229-7yoilsho	3839	10	UCRI	UCRI	NNP
cord-006229-7yoilsho	3839	11	)	)	-RRB-
cord-006229-7yoilsho	3839	12	and	and	CC
cord-006229-7yoilsho	3839	13	downregulated	downregulate	VBD
cord-006229-7yoilsho	3839	14	Acetyl	Acetyl	NNP
cord-006229-7yoilsho	3839	15	-	-	HYPH
cord-006229-7yoilsho	3839	16	CoA	coa	NN
cord-006229-7yoilsho	3839	17	acetyltransferase	acetyltransferase	NN
cord-006229-7yoilsho	3839	18	(	(	-LRB-
cord-006229-7yoilsho	3839	19	THIL	THIL	NNP
cord-006229-7yoilsho	3839	20	)	)	-RRB-
cord-006229-7yoilsho	3839	21	were	be	VBD
cord-006229-7yoilsho	3839	22	among	among	IN
cord-006229-7yoilsho	3839	23	the	the	DT
cord-006229-7yoilsho	3839	24	top	top	JJ
cord-006229-7yoilsho	3839	25	deregulated	deregulate	VBN
cord-006229-7yoilsho	3839	26	proteins	protein	NNS
cord-006229-7yoilsho	3839	27	after	after	IN
cord-006229-7yoilsho	3839	28	2-MCPD	2-mcpd	CD
cord-006229-7yoilsho	3839	29	and	and	CC
cord-006229-7yoilsho	3839	30	2-MCPD	2-mcpd	CD
cord-006229-7yoilsho	3839	31	dipalmitate	dipalmitate	NN
cord-006229-7yoilsho	3839	32	treatment	treatment	NN
cord-006229-7yoilsho	3839	33	.	.	.
cord-006229-7yoilsho	3840	1	Pronounced	pronounce	VBN
cord-006229-7yoilsho	3840	2	upregulation	upregulation	NN
cord-006229-7yoilsho	3840	3	of	of	IN
cord-006229-7yoilsho	3840	4	respiratory	respiratory	JJ
cord-006229-7yoilsho	3840	5	chain	chain	NN
cord-006229-7yoilsho	3840	6	protein	protein	NN
cord-006229-7yoilsho	3840	7	UCRI	UCRI	NNP
cord-006229-7yoilsho	3840	8	,	,	,
cord-006229-7yoilsho	3840	9	not	not	RB
cord-006229-7yoilsho	3840	10	deregulated	deregulate	VBN
cord-006229-7yoilsho	3840	11	after	after	IN
cord-006229-7yoilsho	3840	12	3-MCPD	3-mcpd	CD
cord-006229-7yoilsho	3840	13	treatment	treatment	NN
cord-006229-7yoilsho	3840	14	,	,	,
cord-006229-7yoilsho	3840	15	indicates	indicate	VBZ
cord-006229-7yoilsho	3840	16	an	an	DT
cord-006229-7yoilsho	3840	17	effect	effect	NN
cord-006229-7yoilsho	3840	18	on	on	IN
cord-006229-7yoilsho	3840	19	energy	energy	NN
cord-006229-7yoilsho	3840	20	metabolism	metabolism	NN
cord-006229-7yoilsho	3840	21	.	.	.
cord-006229-7yoilsho	3841	1	Downregulation	Downregulation	NNP
cord-006229-7yoilsho	3841	2	of	of	IN
cord-006229-7yoilsho	3841	3	THIL	THIL	NNP
cord-006229-7yoilsho	3841	4	,	,	,
cord-006229-7yoilsho	3841	5	involved	involve	VBN
cord-006229-7yoilsho	3841	6	in	in	IN
cord-006229-7yoilsho	3841	7	ketone	ketone	NN
cord-006229-7yoilsho	3841	8	body	body	NN
cord-006229-7yoilsho	3841	9	metabolism	metabolism	NN
cord-006229-7yoilsho	3841	10	,	,	,
cord-006229-7yoilsho	3841	11	was	be	VBD
cord-006229-7yoilsho	3841	12	only	only	RB
cord-006229-7yoilsho	3841	13	weakly	weakly	RB
cord-006229-7yoilsho	3841	14	affected	affect	VBN
cord-006229-7yoilsho	3841	15	after	after	IN
cord-006229-7yoilsho	3841	16	3-MCPD	3-mcpd	CD
cord-006229-7yoilsho	3841	17	treatment	treatment	NN
cord-006229-7yoilsho	3841	18	.	.	.
cord-006229-7yoilsho	3842	1	Protein	Protein	NNP
cord-006229-7yoilsho	3842	2	DJ-1	DJ-1	NNP
cord-006229-7yoilsho	3842	3	(	(	-LRB-
cord-006229-7yoilsho	3842	4	PARK7	PARK7	NNP
cord-006229-7yoilsho	3842	5	)	)	-RRB-
cord-006229-7yoilsho	3842	6	,	,	,
cord-006229-7yoilsho	3842	7	a	a	DT
cord-006229-7yoilsho	3842	8	multifunctional	multifunctional	JJ
cord-006229-7yoilsho	3842	9	redoxsensitive	redoxsensitive	JJ
cord-006229-7yoilsho	3842	10	chaperone	chaperone	NN
cord-006229-7yoilsho	3842	11	and	and	CC
cord-006229-7yoilsho	3842	12	protease	protease	NN
cord-006229-7yoilsho	3842	13	protecting	protect	VBG
cord-006229-7yoilsho	3842	14	the	the	DT
cord-006229-7yoilsho	3842	15	cell	cell	NN
cord-006229-7yoilsho	3842	16	against	against	IN
cord-006229-7yoilsho	3842	17	oxidative	oxidative	JJ
cord-006229-7yoilsho	3842	18	stress	stress	NN
cord-006229-7yoilsho	3842	19	,	,	,
cord-006229-7yoilsho	3842	20	was	be	VBD
cord-006229-7yoilsho	3842	21	significantly	significantly	RB
cord-006229-7yoilsho	3842	22	downregulated	downregulate	VBN
cord-006229-7yoilsho	3842	23	after	after	IN
cord-006229-7yoilsho	3842	24	treatment	treatment	NN
cord-006229-7yoilsho	3842	25	with	with	IN
cord-006229-7yoilsho	3842	26	3-MCPD	3-mcpd	CD
cord-006229-7yoilsho	3842	27	and	and	CC
cord-006229-7yoilsho	3842	28	the	the	DT
cord-006229-7yoilsho	3842	29	higher	high	JJR
cord-006229-7yoilsho	3842	30	dose	dose	NN
cord-006229-7yoilsho	3842	31	of	of	IN
cord-006229-7yoilsho	3842	32	the	the	DT
cord-006229-7yoilsho	3842	33	2-MCPD	2-mcpd	CD
cord-006229-7yoilsho	3842	34	diester	diester	NN
cord-006229-7yoilsho	3842	35	.	.	.
cord-006229-7yoilsho	3843	1	Tropomyosin	tropomyosin	JJ
cord-006229-7yoilsho	3843	2	beta	beta	NN
cord-006229-7yoilsho	3843	3	chain	chain	NN
cord-006229-7yoilsho	3843	4	(	(	-LRB-
cord-006229-7yoilsho	3843	5	TPM2	TPM2	NNP
cord-006229-7yoilsho	3843	6	)	)	-RRB-
cord-006229-7yoilsho	3843	7	was	be	VBD
cord-006229-7yoilsho	3843	8	commonly	commonly	RB
cord-006229-7yoilsho	3843	9	upregulated	upregulate	VBN
cord-006229-7yoilsho	3843	10	after	after	IN
cord-006229-7yoilsho	3843	11	3-MCPD	3-mcpd	CD
cord-006229-7yoilsho	3843	12	and	and	CC
cord-006229-7yoilsho	3843	13	2-MCPD	2-mcpd	CD
cord-006229-7yoilsho	3843	14	treatments	treatment	NNS
cord-006229-7yoilsho	3843	15	,	,	,
cord-006229-7yoilsho	3843	16	possibly	possibly	RB
cord-006229-7yoilsho	3843	17	indicating	indicate	VBG
cord-006229-7yoilsho	3843	18	a	a	DT
cord-006229-7yoilsho	3843	19	TGF	TGF	NNP
cord-006229-7yoilsho	3843	20	-	-	HYPH
cord-006229-7yoilsho	3843	21	beta	beta	NN
cord-006229-7yoilsho	3843	22	induction	induction	NN
cord-006229-7yoilsho	3843	23	of	of	IN
cord-006229-7yoilsho	3843	24	actin	actin	JJ
cord-006229-7yoilsho	3843	25	stress	stress	NN
cord-006229-7yoilsho	3843	26	fibers	fiber	NNS
cord-006229-7yoilsho	3843	27	.	.	.
cord-006229-7yoilsho	3844	1	For	for	IN
cord-006229-7yoilsho	3844	2	rat	rat	NN
cord-006229-7yoilsho	3844	3	heart	heart	NN
cord-006229-7yoilsho	3844	4	,	,	,
cord-006229-7yoilsho	3844	5	data	datum	NNS
cord-006229-7yoilsho	3844	6	show	show	VBP
cord-006229-7yoilsho	3844	7	that	that	IN
cord-006229-7yoilsho	3844	8	similarities	similarity	NNS
cord-006229-7yoilsho	3844	9	but	but	CC
cord-006229-7yoilsho	3844	10	also	also	RB
cord-006229-7yoilsho	3844	11	some	some	DT
cord-006229-7yoilsho	3844	12	significant	significant	JJ
cord-006229-7yoilsho	3844	13	differences	difference	NNS
cord-006229-7yoilsho	3844	14	of	of	IN
cord-006229-7yoilsho	3844	15	2-MCPD	2-mcpd	CD
cord-006229-7yoilsho	3844	16	-	-	:
cord-006229-7yoilsho	3844	17	and	and	CC
cord-006229-7yoilsho	3844	18	2-MCPD	2-mcpd	CD
cord-006229-7yoilsho	3844	19	dipalmitate	dipalmitate	NN
cord-006229-7yoilsho	3844	20	-	-	HYPH
cord-006229-7yoilsho	3844	21	induced	induce	VBN
cord-006229-7yoilsho	3844	22	proteomic	proteomic	JJ
cord-006229-7yoilsho	3844	23	changes	change	NNS
cord-006229-7yoilsho	3844	24	exist	exist	VBP
cord-006229-7yoilsho	3844	25	compared	compare	VBN
cord-006229-7yoilsho	3844	26	to	to	IN
cord-006229-7yoilsho	3844	27	3-MCPD	3-mcpd	CD
cord-006229-7yoilsho	3844	28	,	,	,
cord-006229-7yoilsho	3844	29	indicating	indicate	VBG
cord-006229-7yoilsho	3844	30	different	different	JJ
cord-006229-7yoilsho	3844	31	mechanisms	mechanism	NNS
cord-006229-7yoilsho	3844	32	of	of	IN
cord-006229-7yoilsho	3844	33	toxicity	toxicity	NN
cord-006229-7yoilsho	3844	34	for	for	IN
cord-006229-7yoilsho	3844	35	this	this	DT
cord-006229-7yoilsho	3844	36	structural	structural	JJ
cord-006229-7yoilsho	3844	37	analogues	analogue	NNS
cord-006229-7yoilsho	3844	38	.	.	.
cord-006229-7yoilsho	3845	1	Oxidation	oxidation	NN
cord-006229-7yoilsho	3845	2	products	product	NNS
cord-006229-7yoilsho	3845	3	(	(	-LRB-
cord-006229-7yoilsho	3845	4	oxy	oxy	NN
cord-006229-7yoilsho	3845	5	)	)	-RRB-
cord-006229-7yoilsho	3845	6	of	of	IN
cord-006229-7yoilsho	3845	7	cholesterol	cholesterol	NN
cord-006229-7yoilsho	3845	8	(	(	-LRB-
cord-006229-7yoilsho	3845	9	ChOL	ChOL	NNP
cord-006229-7yoilsho	3845	10	)	)	-RRB-
cord-006229-7yoilsho	3845	11	such	such	JJ
cord-006229-7yoilsho	3845	12	as	as	IN
cord-006229-7yoilsho	3845	13	7α	7α	CD
cord-006229-7yoilsho	3845	14	-	-	HYPH
cord-006229-7yoilsho	3845	15	hydroxy	hydroxy	NN
cord-006229-7yoilsho	3845	16	-	-	HYPH
cord-006229-7yoilsho	3845	17	ChOL	ChOL	NNP
cord-006229-7yoilsho	3846	1	(	(	-LRB-
cord-006229-7yoilsho	3846	2	7α	7α	CD
cord-006229-7yoilsho	3846	3	-	-	HYPH
cord-006229-7yoilsho	3846	4	HO	HO	NNP
cord-006229-7yoilsho	3846	5	-	-	HYPH
cord-006229-7yoilsho	3846	6	ChOL	ChOL	NNP
cord-006229-7yoilsho	3846	7	)	)	-RRB-
cord-006229-7yoilsho	3846	8	,	,	.
cord-006229-7yoilsho	3847	1	7β	7β	CD
cord-006229-7yoilsho	3847	2	-	-	HYPH
cord-006229-7yoilsho	3847	3	hydroxy	hydroxy	NN
cord-006229-7yoilsho	3847	4	-	-	HYPH
cord-006229-7yoilsho	3847	5	ChOL	chol	NN
cord-006229-7yoilsho	3847	6	(	(	-LRB-
cord-006229-7yoilsho	3847	7	7β	7β	CD
cord-006229-7yoilsho	3847	8	-	-	HYPH
cord-006229-7yoilsho	3847	9	HO	HO	NNP
cord-006229-7yoilsho	3847	10	-	-	HYPH
cord-006229-7yoilsho	3847	11	ChOL	ChOL	NNP
cord-006229-7yoilsho	3847	12	)	)	-RRB-
cord-006229-7yoilsho	3847	13	,	,	,
cord-006229-7yoilsho	3847	14	7-keto	7-keto	NNP
cord-006229-7yoilsho	3847	15	-	-	HYPH
cord-006229-7yoilsho	3847	16	ChOL	ChOL	NNP
cord-006229-7yoilsho	3847	17	(	(	-LRB-
cord-006229-7yoilsho	3847	18	7-O	7-O	NNP
cord-006229-7yoilsho	3847	19	-	-	HYPH
cord-006229-7yoilsho	3847	20	ChOL	ChOL	NNP
cord-006229-7yoilsho	3847	21	)	)	-RRB-
cord-006229-7yoilsho	3847	22	,	,	,
cord-006229-7yoilsho	3847	23	5,6α	5,6α	CD
cord-006229-7yoilsho	3847	24	-	-	HYPH
cord-006229-7yoilsho	3847	25	epoxy	epoxy	NN
cord-006229-7yoilsho	3847	26	-	-	HYPH
cord-006229-7yoilsho	3847	27	ChOL	chol	NN
cord-006229-7yoilsho	3847	28	(	(	-LRB-
cord-006229-7yoilsho	3847	29	α	α	NN
cord-006229-7yoilsho	3847	30	-	-	HYPH
cord-006229-7yoilsho	3847	31	epoxy	epoxy	NN
cord-006229-7yoilsho	3847	32	-	-	HYPH
cord-006229-7yoilsho	3847	33	ChOL	chol	NN
cord-006229-7yoilsho	3847	34	)	)	-RRB-
cord-006229-7yoilsho	3848	1	and	and	CC
cord-006229-7yoilsho	3848	2	5,6β	5,6β	CD
cord-006229-7yoilsho	3848	3	-	-	HYPH
cord-006229-7yoilsho	3848	4	epoxy	epoxy	NN
cord-006229-7yoilsho	3848	5	-	-	HYPH
cord-006229-7yoilsho	3848	6	ChOL	chol	NN
cord-006229-7yoilsho	3848	7	(	(	-LRB-
cord-006229-7yoilsho	3848	8	β	β	NN
cord-006229-7yoilsho	3848	9	-	-	HYPH
cord-006229-7yoilsho	3848	10	epoxy	epoxy	NN
cord-006229-7yoilsho	3848	11	-	-	HYPH
cord-006229-7yoilsho	3848	12	ChOL	chol	NN
cord-006229-7yoilsho	3848	13	)	)	-RRB-
cord-006229-7yoilsho	3848	14	are	be	VBP
cord-006229-7yoilsho	3848	15	formed	form	VBN
cord-006229-7yoilsho	3848	16	by	by	IN
cord-006229-7yoilsho	3848	17	autoxidation	autoxidation	NN
cord-006229-7yoilsho	3848	18	of	of	IN
cord-006229-7yoilsho	3848	19	ChOL	ChOL	NNP
cord-006229-7yoilsho	3848	20	and	and	CC
cord-006229-7yoilsho	3848	21	are	be	VBP
cord-006229-7yoilsho	3848	22	discussed	discuss	VBN
cord-006229-7yoilsho	3848	23	as	as	IN
cord-006229-7yoilsho	3848	24	biomarkers	biomarker	NNS
cord-006229-7yoilsho	3848	25	for	for	IN
cord-006229-7yoilsho	3848	26	inflammation	inflammation	NN
cord-006229-7yoilsho	3848	27	and	and	CC
cord-006229-7yoilsho	3848	28	oxidative	oxidative	JJ
cord-006229-7yoilsho	3848	29	stress	stress	NN
cord-006229-7yoilsho	3848	30	in	in	IN
cord-006229-7yoilsho	3848	31	human	human	JJ
cord-006229-7yoilsho	3848	32	tissues	tissue	NNS
cord-006229-7yoilsho	3848	33	to	to	TO
cord-006229-7yoilsho	3848	34	be	be	VB
cord-006229-7yoilsho	3848	35	used	use	VBN
cord-006229-7yoilsho	3848	36	in	in	IN
cord-006229-7yoilsho	3848	37	the	the	DT
cord-006229-7yoilsho	3848	38	identification	identification	NN
cord-006229-7yoilsho	3848	39	of	of	IN
cord-006229-7yoilsho	3848	40	risk	risk	NN
cord-006229-7yoilsho	3848	41	factors	factor	NNS
cord-006229-7yoilsho	3848	42	for	for	IN
cord-006229-7yoilsho	3848	43	disease	disease	NN
cord-006229-7yoilsho	3848	44	.	.	.
cord-006229-7yoilsho	3849	1	However	however	RB
cord-006229-7yoilsho	3849	2	,	,	,
cord-006229-7yoilsho	3849	3	oxy	oxy	JJ
cord-006229-7yoilsho	3849	4	-	-	HYPH
cord-006229-7yoilsho	3849	5	ChOLs	ChOLs	NNP
cord-006229-7yoilsho	3849	6	are	be	VBP
cord-006229-7yoilsho	3849	7	also	also	RB
cord-006229-7yoilsho	3849	8	present	present	JJ
cord-006229-7yoilsho	3849	9	in	in	IN
cord-006229-7yoilsho	3849	10	processed	process	VBN
cord-006229-7yoilsho	3849	11	foodstuff	foodstuff	NN
cord-006229-7yoilsho	3849	12	where	where	WRB
cord-006229-7yoilsho	3849	13	7β	7β	CD
cord-006229-7yoilsho	3849	14	-	-	HYPH
cord-006229-7yoilsho	3849	15	HO	HO	NNP
cord-006229-7yoilsho	3849	16	-	-	HYPH
cord-006229-7yoilsho	3849	17	ChOL	ChOL	NNP
cord-006229-7yoilsho	3849	18	(	(	-LRB-
cord-006229-7yoilsho	3849	19	milk	milk	NN
cord-006229-7yoilsho	3849	20	)	)	-RRB-
cord-006229-7yoilsho	3849	21	and	and	CC
cord-006229-7yoilsho	3849	22	7-O	7-o	CD
cord-006229-7yoilsho	3849	23	-	-	HYPH
cord-006229-7yoilsho	3849	24	ChOL	chol	NN
cord-006229-7yoilsho	3849	25	(	(	-LRB-
cord-006229-7yoilsho	3849	26	fish	fish	NN
cord-006229-7yoilsho	3849	27	,	,	,
cord-006229-7yoilsho	3849	28	meat	meat	NN
cord-006229-7yoilsho	3849	29	,	,	,
cord-006229-7yoilsho	3849	30	and	and	CC
cord-006229-7yoilsho	3849	31	egg	egg	NN
cord-006229-7yoilsho	3849	32	)	)	-RRB-
cord-006229-7yoilsho	3849	33	tend	tend	VBP
cord-006229-7yoilsho	3849	34	to	to	TO
cord-006229-7yoilsho	3849	35	represent	represent	VB
cord-006229-7yoilsho	3849	36	the	the	DT
cord-006229-7yoilsho	3849	37	main	main	JJ
cord-006229-7yoilsho	3849	38	oxyChOLs	oxychols	NN
cord-006229-7yoilsho	3849	39	,	,	,
cord-006229-7yoilsho	3849	40	whereas	whereas	IN
cord-006229-7yoilsho	3849	41	epoxy	epoxy	NN
cord-006229-7yoilsho	3849	42	-	-	HYPH
cord-006229-7yoilsho	3849	43	ChOLs	ChOLs	NNP
cord-006229-7yoilsho	3849	44	,	,	,
cord-006229-7yoilsho	3849	45	are	be	VBP
cord-006229-7yoilsho	3849	46	generally	generally	RB
cord-006229-7yoilsho	3849	47	minor	minor	JJ
cord-006229-7yoilsho	3849	48	constituents	constituent	NNS
cord-006229-7yoilsho	3849	49	.	.	.
cord-006229-7yoilsho	3850	1	Thus	thus	RB
cord-006229-7yoilsho	3850	2	,	,	,
cord-006229-7yoilsho	3850	3	levels	level	NNS
cord-006229-7yoilsho	3850	4	of	of	IN
cord-006229-7yoilsho	3850	5	oxyChOLs	oxychols	NN
cord-006229-7yoilsho	3850	6	in	in	IN
cord-006229-7yoilsho	3850	7	tissues	tissue	NNS
cord-006229-7yoilsho	3850	8	may	may	MD
cord-006229-7yoilsho	3850	9	result	result	VB
cord-006229-7yoilsho	3850	10	from	from	IN
cord-006229-7yoilsho	3850	11	both	both	DT
cord-006229-7yoilsho	3850	12	endogenous	endogenous	JJ
cord-006229-7yoilsho	3850	13	formation	formation	NN
cord-006229-7yoilsho	3850	14	as	as	RB
cord-006229-7yoilsho	3850	15	well	well	RB
cord-006229-7yoilsho	3850	16	as	as	IN
cord-006229-7yoilsho	3850	17	dietary	dietary	JJ
cord-006229-7yoilsho	3850	18	exposure	exposure	NN
cord-006229-7yoilsho	3850	19	.	.	.
cord-006229-7yoilsho	3851	1	Since	since	IN
cord-006229-7yoilsho	3851	2	quantitative	quantitative	JJ
cord-006229-7yoilsho	3851	3	profiles	profile	NNS
cord-006229-7yoilsho	3851	4	of	of	IN
cord-006229-7yoilsho	3851	5	oxy	oxy	JJ
cord-006229-7yoilsho	3851	6	-	-	HYPH
cord-006229-7yoilsho	3851	7	ChOLs	ChOLs	NNP
cord-006229-7yoilsho	3851	8	have	have	VBP
cord-006229-7yoilsho	3851	9	not	not	RB
cord-006229-7yoilsho	3851	10	been	be	VBN
cord-006229-7yoilsho	3851	11	determined	determine	VBN
cord-006229-7yoilsho	3851	12	in	in	IN
cord-006229-7yoilsho	3851	13	human	human	JJ
cord-006229-7yoilsho	3851	14	adipose	adipose	JJ
cord-006229-7yoilsho	3851	15	tissues	tissue	NNS
cord-006229-7yoilsho	3851	16	yet	yet	RB
cord-006229-7yoilsho	3851	17	,	,	,
cord-006229-7yoilsho	3851	18	levels	level	NNS
cord-006229-7yoilsho	3851	19	of	of	IN
cord-006229-7yoilsho	3851	20	oxyChOLs	oxychols	NN
cord-006229-7yoilsho	3851	21	and	and	CC
cord-006229-7yoilsho	3851	22	ChOL	ChOL	NNP
cord-006229-7yoilsho	3851	23	were	be	VBD
cord-006229-7yoilsho	3851	24	quantified	quantify	VBN
cord-006229-7yoilsho	3851	25	using	use	VBG
cord-006229-7yoilsho	3851	26	GC	GC	NNP
cord-006229-7yoilsho	3851	27	-	-	HYPH
cord-006229-7yoilsho	3851	28	MS	MS	NNP
cord-006229-7yoilsho	3851	29	/	/	SYM
cord-006229-7yoilsho	3851	30	MS	MS	NNP
cord-006229-7yoilsho	3851	31	(	(	-LRB-
cord-006229-7yoilsho	3851	32	internal	internal	JJ
cord-006229-7yoilsho	3851	33	standards	standard	NNS
cord-006229-7yoilsho	3851	34	:	:	:
cord-006229-7yoilsho	3851	35	deuterated	deuterate	VBN
cord-006229-7yoilsho	3851	36	oxyChOLs	oxychol	NNS
cord-006229-7yoilsho	3851	37	)	)	-RRB-
cord-006229-7yoilsho	3851	38	and	and	CC
cord-006229-7yoilsho	3851	39	GC	GC	NNP
cord-006229-7yoilsho	3851	40	-	-	HYPH
cord-006229-7yoilsho	3851	41	FID	FID	NNP
cord-006229-7yoilsho	3851	42	(	(	-LRB-
cord-006229-7yoilsho	3851	43	internal	internal	JJ
cord-006229-7yoilsho	3851	44	standard	standard	NN
cord-006229-7yoilsho	3851	45	:	:	:
cord-006229-7yoilsho	3851	46	5α	5α	CD
cord-006229-7yoilsho	3851	47	-	-	HYPH
cord-006229-7yoilsho	3851	48	cholestan-3β	cholestan-3β	NN
cord-006229-7yoilsho	3851	49	-	-	HYPH
cord-006229-7yoilsho	3851	50	ol	ol	NN
cord-006229-7yoilsho	3851	51	)	)	-RRB-
cord-006229-7yoilsho	3851	52	,	,	,
cord-006229-7yoilsho	3851	53	respectively	respectively	RB
cord-006229-7yoilsho	3851	54	in	in	IN
cord-006229-7yoilsho	3851	55	breast	breast	NN
cord-006229-7yoilsho	3851	56	adipose	adipose	JJ
cord-006229-7yoilsho	3851	57	tissues	tissue	NNS
cord-006229-7yoilsho	3851	58	of	of	IN
cord-006229-7yoilsho	3851	59	48	48	CD
cord-006229-7yoilsho	3851	60	healthy	healthy	JJ
cord-006229-7yoilsho	3851	61	women	woman	NNS
cord-006229-7yoilsho	3851	62	undergoing	undergo	VBG
cord-006229-7yoilsho	3851	63	mammoplasty	mammoplasty	NNP
cord-006229-7yoilsho	3851	64	.	.	.
cord-006229-7yoilsho	3852	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	3852	2	,	,	,
cord-006229-7yoilsho	3852	3	tissue	tissue	NN
cord-006229-7yoilsho	3852	4	levels	level	NNS
cord-006229-7yoilsho	3852	5	of	of	IN
cord-006229-7yoilsho	3852	6	25	25	CD
cord-006229-7yoilsho	3852	7	fatty	fatty	JJ
cord-006229-7yoilsho	3852	8	acids	acid	NNS
cord-006229-7yoilsho	3852	9	in	in	IN
cord-006229-7yoilsho	3852	10	adipose	adipose	JJ
cord-006229-7yoilsho	3852	11	tissues	tissue	NNS
cord-006229-7yoilsho	3852	12	were	be	VBD
cord-006229-7yoilsho	3852	13	determined	determine	VBN
cord-006229-7yoilsho	3852	14	by	by	IN
cord-006229-7yoilsho	3852	15	GC	GC	NNP
cord-006229-7yoilsho	3852	16	-	-	HYPH
cord-006229-7yoilsho	3852	17	FID	FID	NNP
cord-006229-7yoilsho	3852	18	(	(	-LRB-
cord-006229-7yoilsho	3852	19	internal	internal	JJ
cord-006229-7yoilsho	3852	20	standard	standard	NN
cord-006229-7yoilsho	3852	21	:	:	:
cord-006229-7yoilsho	3852	22	undecanoic	undecanoic	NNP
cord-006229-7yoilsho	3852	23	acid	acid	NNP
cord-006229-7yoilsho	3852	24	)	)	-RRB-
cord-006229-7yoilsho	3852	25	to	to	TO
cord-006229-7yoilsho	3852	26	assess	assess	VB
cord-006229-7yoilsho	3852	27	relative	relative	JJ
cord-006229-7yoilsho	3852	28	levels	level	NNS
cord-006229-7yoilsho	3852	29	of	of	IN
cord-006229-7yoilsho	3852	30	pentadecanoic	pentadecanoic	NNP
cord-006229-7yoilsho	3852	31	acid	acid	NN
cord-006229-7yoilsho	3852	32	,	,	,
cord-006229-7yoilsho	3852	33	docosahexaenoic	docosahexaenoic	NNP
cord-006229-7yoilsho	3852	34	acid	acid	NN
cord-006229-7yoilsho	3852	35	and	and	CC
cord-006229-7yoilsho	3852	36	elaidic	elaidic	NNP
cord-006229-7yoilsho	3852	37	acid	acid	NN
cord-006229-7yoilsho	3852	38	,	,	,
cord-006229-7yoilsho	3852	39	indicative	indicative	JJ
cord-006229-7yoilsho	3852	40	for	for	IN
cord-006229-7yoilsho	3852	41	consumption	consumption	NN
cord-006229-7yoilsho	3852	42	of	of	IN
cord-006229-7yoilsho	3852	43	dairy	dairy	NN
cord-006229-7yoilsho	3852	44	products	product	NNS
cord-006229-7yoilsho	3852	45	,	,	,
cord-006229-7yoilsho	3852	46	fish	fish	NN
cord-006229-7yoilsho	3852	47	,	,	,
cord-006229-7yoilsho	3852	48	and	and	CC
cord-006229-7yoilsho	3852	49	processed	process	VBN
cord-006229-7yoilsho	3852	50	fats	fat	NNS
cord-006229-7yoilsho	3852	51	,	,	,
cord-006229-7yoilsho	3852	52	respectively	respectively	RB
cord-006229-7yoilsho	3852	53	.	.	.
cord-006229-7yoilsho	3853	1	All	all	DT
cord-006229-7yoilsho	3853	2	oxyChOLs	oxychol	NNS
cord-006229-7yoilsho	3853	3	were	be	VBD
cord-006229-7yoilsho	3853	4	detected	detect	VBN
cord-006229-7yoilsho	3853	5	in	in	IN
cord-006229-7yoilsho	3853	6	all	all	DT
cord-006229-7yoilsho	3853	7	breast	breast	NN
cord-006229-7yoilsho	3853	8	adipose	adipose	JJ
cord-006229-7yoilsho	3853	9	tissues	tissue	NNS
cord-006229-7yoilsho	3853	10	.	.	.
cord-006229-7yoilsho	3854	1	The	the	DT
cord-006229-7yoilsho	3854	2	most	most	RBS
cord-006229-7yoilsho	3854	3	abundant	abundant	JJ
cord-006229-7yoilsho	3854	4	oxyChoL	oxychol	NN
cord-006229-7yoilsho	3854	5	was	be	VBD
cord-006229-7yoilsho	3854	6	β	β	NN
cord-006229-7yoilsho	3854	7	-	-	HYPH
cord-006229-7yoilsho	3854	8	epoxy	epoxy	NN
cord-006229-7yoilsho	3854	9	-	-	HYPH
cord-006229-7yoilsho	3854	10	ChOL	chol	NN
cord-006229-7yoilsho	3855	1	(	(	-LRB-
cord-006229-7yoilsho	3855	2	median	median	NN
cord-006229-7yoilsho	3855	3	:	:	:
cord-006229-7yoilsho	3855	4	0.36	0.36	CD
cord-006229-7yoilsho	3855	5	nmol	nmol	JJ
cord-006229-7yoilsho	3855	6	/	/	SYM
cord-006229-7yoilsho	3855	7	g	g	NN
cord-006229-7yoilsho	3855	8	tissue	tissue	NN
cord-006229-7yoilsho	3855	9	,	,	,
cord-006229-7yoilsho	3855	10	range	range	NN
cord-006229-7yoilsho	3855	11	:	:	:
cord-006229-7yoilsho	3855	12	0.06	0.06	CD
cord-006229-7yoilsho	3855	13	-	-	SYM
cord-006229-7yoilsho	3855	14	1.55	1.55	CD
cord-006229-7yoilsho	3855	15	nmol	nmol	JJ
cord-006229-7yoilsho	3855	16	/	/	SYM
cord-006229-7yoilsho	3855	17	g	g	NN
cord-006229-7yoilsho	3855	18	)	)	-RRB-
cord-006229-7yoilsho	3855	19	,	,	,
cord-006229-7yoilsho	3855	20	followed	follow	VBN
cord-006229-7yoilsho	3855	21	by	by	IN
cord-006229-7yoilsho	3856	1	α	α	NN
cord-006229-7yoilsho	3856	2	-	-	HYPH
cord-006229-7yoilsho	3856	3	epoxy	epoxy	NN
cord-006229-7yoilsho	3856	4	-	-	HYPH
cord-006229-7yoilsho	3856	5	ChOL	chol	NN
cord-006229-7yoilsho	3856	6	>	>	XX
cord-006229-7yoilsho	3856	7	7-O	7-o	CD
cord-006229-7yoilsho	3856	8	-	-	HYPH
cord-006229-7yoilsho	3856	9	ChOL	chol	NN
cord-006229-7yoilsho	3856	10	>	>	XX
cord-006229-7yoilsho	3857	1	7α	7α	CD
cord-006229-7yoilsho	3857	2	-	-	HYPH
cord-006229-7yoilsho	3857	3	HO	HO	NNP
cord-006229-7yoilsho	3857	4	-	-	HYPH
cord-006229-7yoilsho	3857	5	ChOL	ChOL	NNP
cord-006229-7yoilsho	3858	1	>	>	XX
cord-006229-7yoilsho	3859	1	7β	7β	LS
cord-006229-7yoilsho	3859	2	-	-	HYPH
cord-006229-7yoilsho	3859	3	HO	HO	NNP
cord-006229-7yoilsho	3859	4	-	-	HYPH
cord-006229-7yoilsho	3859	5	ChOL	ChOL	NNP
cord-006229-7yoilsho	3859	6	(	(	-LRB-
cord-006229-7yoilsho	3859	7	0.009	0.009	CD
cord-006229-7yoilsho	3859	8	nmol	nmol	JJ
cord-006229-7yoilsho	3859	9	/	/	SYM
cord-006229-7yoilsho	3859	10	g	g	NN
cord-006229-7yoilsho	3859	11	,	,	,
cord-006229-7yoilsho	3859	12	range	range	NN
cord-006229-7yoilsho	3859	13	:	:	:
cord-006229-7yoilsho	3859	14	0.002	0.002	CD
cord-006229-7yoilsho	3859	15	-	-	HYPH
cord-006229-7yoilsho	3859	16	0.11	0.11	CD
cord-006229-7yoilsho	3859	17	nmol	nmol	JJ
cord-006229-7yoilsho	3859	18	/	/	SYM
cord-006229-7yoilsho	3859	19	g	g	NN
cord-006229-7yoilsho	3859	20	)	)	-RRB-
cord-006229-7yoilsho	3859	21	.	.	.
cord-006229-7yoilsho	3860	1	Tissue	tissue	NN
cord-006229-7yoilsho	3860	2	levels	level	NNS
cord-006229-7yoilsho	3860	3	of	of	IN
cord-006229-7yoilsho	3860	4	ChOL	ChOL	NNP
cord-006229-7yoilsho	3860	5	(	(	-LRB-
cord-006229-7yoilsho	3860	6	2.8	2.8	CD
cord-006229-7yoilsho	3860	7	micro	micro	NNP
cord-006229-7yoilsho	3860	8	mol	mol	NNP
cord-006229-7yoilsho	3860	9	/	/	SYM
cord-006229-7yoilsho	3860	10	g	g	NNP
cord-006229-7yoilsho	3860	11	,	,	,
cord-006229-7yoilsho	3860	12	range	range	NN
cord-006229-7yoilsho	3860	13	:	:	:
cord-006229-7yoilsho	3860	14	1.88	1.88	CD
cord-006229-7yoilsho	3860	15	-	-	SYM
cord-006229-7yoilsho	3860	16	3.87	3.87	CD
cord-006229-7yoilsho	3860	17	micro	micro	NNP
cord-006229-7yoilsho	3860	18	mol	mol	NNP
cord-006229-7yoilsho	3860	19	/	/	SYM
cord-006229-7yoilsho	3860	20	g	g	NNP
cord-006229-7yoilsho	3860	21	)	)	-RRB-
cord-006229-7yoilsho	3860	22	did	do	VBD
cord-006229-7yoilsho	3860	23	not	not	RB
cord-006229-7yoilsho	3860	24	correlate	correlate	VB
cord-006229-7yoilsho	3860	25	(	(	-LRB-
cord-006229-7yoilsho	3860	26	Spearman	Spearman	NNP
cord-006229-7yoilsho	3860	27	's	's	POS
cord-006229-7yoilsho	3860	28	rank	rank	NN
cord-006229-7yoilsho	3860	29	analysis	analysis	NN
cord-006229-7yoilsho	3860	30	)	)	-RRB-
cord-006229-7yoilsho	3860	31	with	with	IN
cord-006229-7yoilsho	3860	32	that	that	DT
cord-006229-7yoilsho	3860	33	of	of	IN
cord-006229-7yoilsho	3860	34	epoxy	epoxy	NN
cord-006229-7yoilsho	3860	35	-	-	HYPH
cord-006229-7yoilsho	3860	36	Chols	Chols	NNP
cord-006229-7yoilsho	3860	37	and	and	CC
cord-006229-7yoilsho	3860	38	correlated	correlate	VBD
cord-006229-7yoilsho	3860	39	even	even	RB
cord-006229-7yoilsho	3860	40	negatively	negatively	RB
cord-006229-7yoilsho	3860	41	with	with	IN
cord-006229-7yoilsho	3860	42	that	that	DT
cord-006229-7yoilsho	3860	43	of	of	IN
cord-006229-7yoilsho	3860	44	7α	7α	CD
cord-006229-7yoilsho	3860	45	-	-	HYPH
cord-006229-7yoilsho	3860	46	HO-	ho-	CD
cord-006229-7yoilsho	3860	47	,	,	,
cord-006229-7yoilsho	3860	48	7β	7β	CD
cord-006229-7yoilsho	3860	49	-	-	HYPH
cord-006229-7yoilsho	3860	50	HO-	ho-	NN
cord-006229-7yoilsho	3860	51	,	,	,
cord-006229-7yoilsho	3860	52	and	and	CC
cord-006229-7yoilsho	3861	1	7-O	7-o	LS
cord-006229-7yoilsho	3861	2	-	-	HYPH
cord-006229-7yoilsho	3861	3	ChOL	ChOL	NNP
cord-006229-7yoilsho	3861	4	(	(	-LRB-
cord-006229-7yoilsho	3861	5	R	r	NN
cord-006229-7yoilsho	3861	6	=	=	SYM
cord-006229-7yoilsho	3861	7	-0.29	-0.29	ADD
cord-006229-7yoilsho	3861	8	,	,	,
cord-006229-7yoilsho	3861	9	p=0.024	p=0.024	NN
cord-006229-7yoilsho	3861	10	-	-	HYPH
cord-006229-7yoilsho	3861	11	0.044	0.044	CD
cord-006229-7yoilsho	3861	12	)	)	-RRB-
cord-006229-7yoilsho	3862	1	Median	median	JJ
cord-006229-7yoilsho	3862	2	oxyChOL	oxychol	NN
cord-006229-7yoilsho	3862	3	/	/	SYM
cord-006229-7yoilsho	3862	4	ChOL	chol	NN
cord-006229-7yoilsho	3862	5	ratios	ratio	NNS
cord-006229-7yoilsho	3862	6	ranged	range	VBD
cord-006229-7yoilsho	3862	7	from	from	IN
cord-006229-7yoilsho	3862	8	0.0119	0.0119	CD
cord-006229-7yoilsho	3862	9	(	(	-LRB-
cord-006229-7yoilsho	3862	10	5	5	CD
cord-006229-7yoilsho	3862	11	,	,	,
cord-006229-7yoilsho	3862	12	to	to	IN
cord-006229-7yoilsho	3862	13	0.0003	0.0003	CD
cord-006229-7yoilsho	3862	14	(	(	-LRB-
cord-006229-7yoilsho	3862	15	7β	7β	CD
cord-006229-7yoilsho	3862	16	-	-	HYPH
cord-006229-7yoilsho	3862	17	HO	HO	NNP
cord-006229-7yoilsho	3862	18	-	-	HYPH
cord-006229-7yoilsho	3862	19	ChOL	ChOL	NNP
cord-006229-7yoilsho	3862	20	)	)	-RRB-
cord-006229-7yoilsho	3862	21	.	.	.
cord-006229-7yoilsho	3863	1	7-O	7-o	LS
cord-006229-7yoilsho	3863	2	-	-	:
cord-006229-7yoilsho	3863	3	Chol	Chol	NNP
cord-006229-7yoilsho	3863	4	and	and	CC
cord-006229-7yoilsho	3863	5	7-HO	7-ho	CD
cord-006229-7yoilsho	3863	6	-	-	HYPH
cord-006229-7yoilsho	3863	7	ChOLs	chols	NN
cord-006229-7yoilsho	3863	8	correlated	correlate	VBD
cord-006229-7yoilsho	3863	9	strongly	strongly	RB
cord-006229-7yoilsho	3863	10	with	with	IN
cord-006229-7yoilsho	3863	11	each	each	DT
cord-006229-7yoilsho	3863	12	other	other	JJ
cord-006229-7yoilsho	3863	13	(	(	-LRB-
cord-006229-7yoilsho	3863	14	R=0.81	R=0.81	NNS
cord-006229-7yoilsho	3863	15	-	-	HYPH
cord-006229-7yoilsho	3863	16	0.91	0.91	CD
cord-006229-7yoilsho	3863	17	,	,	,
cord-006229-7yoilsho	3863	18	p	p	NNP
cord-006229-7yoilsho	3863	19	Oxy	Oxy	NNP
cord-006229-7yoilsho	3863	20	-	-	HYPH
cord-006229-7yoilsho	3863	21	ChOL	ChOL	NNP
cord-006229-7yoilsho	3863	22	levels	level	NNS
cord-006229-7yoilsho	3863	23	did	do	VBD
cord-006229-7yoilsho	3863	24	not	not	RB
cord-006229-7yoilsho	3863	25	correlate	correlate	VB
cord-006229-7yoilsho	3863	26	with	with	IN
cord-006229-7yoilsho	3863	27	relative	relative	JJ
cord-006229-7yoilsho	3863	28	amounts	amount	NNS
cord-006229-7yoilsho	3863	29	of	of	IN
cord-006229-7yoilsho	3863	30	pentadecanoic	pentadecanoic	JJ
cord-006229-7yoilsho	3863	31	acid	acid	NNP
cord-006229-7yoilsho	3863	32	and	and	CC
cord-006229-7yoilsho	3863	33	docosahexaenoic	docosahexaenoic	NNP
cord-006229-7yoilsho	3863	34	acid	acid	NN
cord-006229-7yoilsho	3863	35	,	,	,
cord-006229-7yoilsho	3863	36	whereas	whereas	IN
cord-006229-7yoilsho	3863	37	total	total	JJ
cord-006229-7yoilsho	3863	38	oxyChOL	oxychol	NN
cord-006229-7yoilsho	3863	39	,	,	,
cord-006229-7yoilsho	3863	40	7β	7β	CD
cord-006229-7yoilsho	3863	41	-	-	HYPH
cord-006229-7yoilsho	3863	42	HO	HO	NNP
cord-006229-7yoilsho	3863	43	-	-	HYPH
cord-006229-7yoilsho	3863	44	ChOL	ChOL	NNP
cord-006229-7yoilsho	3863	45	,	,	,
cord-006229-7yoilsho	3863	46	and	and	CC
cord-006229-7yoilsho	3863	47	β	β	NN
cord-006229-7yoilsho	3863	48	-	-	HYPH
cord-006229-7yoilsho	3863	49	epoxy	epoxy	NN
cord-006229-7yoilsho	3863	50	-	-	HYPH
cord-006229-7yoilsho	3863	51	ChOL	chol	NN
cord-006229-7yoilsho	3863	52	levels	level	NNS
cord-006229-7yoilsho	3863	53	correlated	correlate	VBN
cord-006229-7yoilsho	3863	54	with	with	IN
cord-006229-7yoilsho	3863	55	relative	relative	JJ
cord-006229-7yoilsho	3863	56	amounts	amount	NNS
cord-006229-7yoilsho	3863	57	of	of	IN
cord-006229-7yoilsho	3863	58	elaidic	elaidic	JJ
cord-006229-7yoilsho	3863	59	acid	acid	NN
cord-006229-7yoilsho	3863	60	(	(	-LRB-
cord-006229-7yoilsho	3863	61	R=0.30	R=0.30	NNP
cord-006229-7yoilsho	3863	62	,	,	,
cord-006229-7yoilsho	3863	63	0.30	0.30	CD
cord-006229-7yoilsho	3863	64	,	,	,
cord-006229-7yoilsho	3863	65	and	and	CC
cord-006229-7yoilsho	3863	66	0.31	0.31	CD
cord-006229-7yoilsho	3863	67	,	,	,
cord-006229-7yoilsho	3863	68	respectively	respectively	RB
cord-006229-7yoilsho	3863	69	,	,	,
cord-006229-7yoilsho	3863	70	p=0.037	p=0.037	NNP
cord-006229-7yoilsho	3863	71	,	,	,
cord-006229-7yoilsho	3863	72	0.034	0.034	CD
cord-006229-7yoilsho	3863	73	,	,	,
cord-006229-7yoilsho	3863	74	0.028	0.028	CD
cord-006229-7yoilsho	3863	75	,	,	,
cord-006229-7yoilsho	3863	76	respectively	respectively	RB
cord-006229-7yoilsho	3863	77	)	)	-RRB-
cord-006229-7yoilsho	3863	78	.	.	.
cord-006229-7yoilsho	3864	1	No	no	DT
cord-006229-7yoilsho	3864	2	correlations	correlation	NNS
cord-006229-7yoilsho	3864	3	of	of	IN
cord-006229-7yoilsho	3864	4	oxyChOL	oxychol	NN
cord-006229-7yoilsho	3864	5	levels	level	NNS
cord-006229-7yoilsho	3864	6	,	,	,
cord-006229-7yoilsho	3864	7	individual	individual	JJ
cord-006229-7yoilsho	3864	8	or	or	CC
cord-006229-7yoilsho	3864	9	total	total	JJ
cord-006229-7yoilsho	3864	10	oxyChOL	oxyChOL	NNP
cord-006229-7yoilsho	3864	11	/	/	SYM
cord-006229-7yoilsho	3864	12	ChOL	chol	NN
cord-006229-7yoilsho	3864	13	ratios	ratio	NNS
cord-006229-7yoilsho	3864	14	with	with	IN
cord-006229-7yoilsho	3864	15	age	age	NN
cord-006229-7yoilsho	3864	16	or	or	CC
cord-006229-7yoilsho	3864	17	BMI	BMI	NNP
cord-006229-7yoilsho	3864	18	were	be	VBD
cord-006229-7yoilsho	3864	19	observed	observe	VBN
cord-006229-7yoilsho	3864	20	.	.	.
cord-006229-7yoilsho	3865	1	Taken	take	VBN
cord-006229-7yoilsho	3865	2	together	together	RB
cord-006229-7yoilsho	3865	3	,	,	,
cord-006229-7yoilsho	3865	4	oxyChOL	oxychol	NN
cord-006229-7yoilsho	3865	5	profiles	profile	NNS
cord-006229-7yoilsho	3865	6	in	in	IN
cord-006229-7yoilsho	3865	7	breast	breast	NN
cord-006229-7yoilsho	3865	8	adipose	adipose	JJ
cord-006229-7yoilsho	3865	9	tissues	tissue	NNS
cord-006229-7yoilsho	3865	10	were	be	VBD
cord-006229-7yoilsho	3865	11	different	different	JJ
cord-006229-7yoilsho	3865	12	from	from	IN
cord-006229-7yoilsho	3865	13	that	that	DT
cord-006229-7yoilsho	3865	14	usually	usually	RB
cord-006229-7yoilsho	3865	15	present	present	JJ
cord-006229-7yoilsho	3865	16	in	in	IN
cord-006229-7yoilsho	3865	17	food	food	NN
cord-006229-7yoilsho	3865	18	but	but	CC
cord-006229-7yoilsho	3865	19	could	could	MD
cord-006229-7yoilsho	3865	20	be	be	VB
cord-006229-7yoilsho	3865	21	affected	affect	VBN
cord-006229-7yoilsho	3865	22	by	by	IN
cord-006229-7yoilsho	3865	23	dietary	dietary	JJ
cord-006229-7yoilsho	3865	24	habits	habit	NNS
cord-006229-7yoilsho	3865	25	.	.	.
cord-006229-7yoilsho	3866	1	Classification	classification	NN
cord-006229-7yoilsho	3866	2	and	and	CC
cord-006229-7yoilsho	3866	3	labelling	labelling	NN
cord-006229-7yoilsho	3866	4	of	of	IN
cord-006229-7yoilsho	3866	5	hazardous	hazardous	JJ
cord-006229-7yoilsho	3866	6	substances	substance	NNS
cord-006229-7yoilsho	3866	7	and	and	CC
cord-006229-7yoilsho	3866	8	hazardous	hazardous	JJ
cord-006229-7yoilsho	3866	9	consumer	consumer	NN
cord-006229-7yoilsho	3866	10	products	product	NNS
cord-006229-7yoilsho	3866	11	(	(	-LRB-
cord-006229-7yoilsho	3866	12	1	1	CD
cord-006229-7yoilsho	3866	13	)	)	-RRB-
cord-006229-7yoilsho	3866	14	has	have	VBZ
cord-006229-7yoilsho	3866	15	proven	prove	VBN
cord-006229-7yoilsho	3866	16	to	to	TO
cord-006229-7yoilsho	3866	17	be	be	VB
cord-006229-7yoilsho	3866	18	a	a	DT
cord-006229-7yoilsho	3866	19	very	very	RB
cord-006229-7yoilsho	3866	20	efficient	efficient	JJ
cord-006229-7yoilsho	3866	21	tool	tool	NN
cord-006229-7yoilsho	3866	22	for	for	IN
cord-006229-7yoilsho	3866	23	risk	risk	NN
cord-006229-7yoilsho	3866	24	communication	communication	NN
cord-006229-7yoilsho	3866	25	.	.	.
cord-006229-7yoilsho	3867	1	Consumer	consumer	NN
cord-006229-7yoilsho	3867	2	products	product	NNS
cord-006229-7yoilsho	3867	3	,	,	,
cord-006229-7yoilsho	3867	4	such	such	JJ
cord-006229-7yoilsho	3867	5	as	as	IN
cord-006229-7yoilsho	3867	6	glue	glue	NN
cord-006229-7yoilsho	3867	7	,	,	,
cord-006229-7yoilsho	3867	8	varnish	varnish	NN
cord-006229-7yoilsho	3867	9	,	,	,
cord-006229-7yoilsho	3867	10	or	or	CC
cord-006229-7yoilsho	3867	11	washing	washing	NN
cord-006229-7yoilsho	3867	12	and	and	CC
cord-006229-7yoilsho	3867	13	cleansing	cleansing	NN
cord-006229-7yoilsho	3867	14	products	product	NNS
cord-006229-7yoilsho	3867	15	need	need	VBP
cord-006229-7yoilsho	3867	16	to	to	TO
cord-006229-7yoilsho	3867	17	be	be	VB
cord-006229-7yoilsho	3867	18	classified	classify	VBN
cord-006229-7yoilsho	3867	19	and	and	CC
cord-006229-7yoilsho	3867	20	labelled	label	VBN
cord-006229-7yoilsho	3867	21	if	if	IN
cord-006229-7yoilsho	3867	22	they	-PRON-	PRP
cord-006229-7yoilsho	3867	23	contain	contain	VBP
cord-006229-7yoilsho	3867	24	dangerous	dangerous	JJ
cord-006229-7yoilsho	3867	25	ingredients	ingredient	NNS
cord-006229-7yoilsho	3867	26	that	that	WDT
cord-006229-7yoilsho	3867	27	render	render	VBP
cord-006229-7yoilsho	3867	28	the	the	DT
cord-006229-7yoilsho	3867	29	mixture	mixture	NN
cord-006229-7yoilsho	3867	30	hazardous	hazardous	JJ
cord-006229-7yoilsho	3867	31	.	.	.
cord-006229-7yoilsho	3868	1	Personal	personal	JJ
cord-006229-7yoilsho	3868	2	care	care	NN
cord-006229-7yoilsho	3868	3	products	product	NNS
cord-006229-7yoilsho	3868	4	,	,	,
cord-006229-7yoilsho	3868	5	however	however	RB
cord-006229-7yoilsho	3868	6	,	,	,
cord-006229-7yoilsho	3868	7	need	nee	MD
cord-006229-7yoilsho	3868	8	not	not	RB
cord-006229-7yoilsho	3868	9	be	be	VB
cord-006229-7yoilsho	3868	10	classified	classify	VBN
cord-006229-7yoilsho	3868	11	and	and	CC
cord-006229-7yoilsho	3868	12	labelled	label	VBN
cord-006229-7yoilsho	3868	13	if	if	IN
cord-006229-7yoilsho	3868	14	they	-PRON-	PRP
cord-006229-7yoilsho	3868	15	contain	contain	VBP
cord-006229-7yoilsho	3868	16	dangerous	dangerous	JJ
cord-006229-7yoilsho	3868	17	substances	substance	NNS
cord-006229-7yoilsho	3868	18	above	above	IN
cord-006229-7yoilsho	3868	19	the	the	DT
cord-006229-7yoilsho	3868	20	thresholds	threshold	NNS
cord-006229-7yoilsho	3868	21	for	for	IN
cord-006229-7yoilsho	3868	22	classification	classification	NN
cord-006229-7yoilsho	3868	23	.	.	.
cord-006229-7yoilsho	3869	1	They	-PRON-	PRP
cord-006229-7yoilsho	3869	2	are	be	VBP
cord-006229-7yoilsho	3869	3	excluded	exclude	VBN
cord-006229-7yoilsho	3869	4	in	in	IN
cord-006229-7yoilsho	3869	5	the	the	DT
cord-006229-7yoilsho	3869	6	CLP	CLP	NNP
cord-006229-7yoilsho	3869	7	regulation	regulation	NN
cord-006229-7yoilsho	3869	8	.	.	.
cord-006229-7yoilsho	3870	1	What	what	WP
cord-006229-7yoilsho	3870	2	would	would	MD
cord-006229-7yoilsho	3870	3	happen	happen	VB
cord-006229-7yoilsho	3870	4	without	without	IN
cord-006229-7yoilsho	3870	5	this	this	DT
cord-006229-7yoilsho	3870	6	exception	exception	NN
cord-006229-7yoilsho	3870	7	?	?	.
cord-006229-7yoilsho	3871	1	When	when	WRB
cord-006229-7yoilsho	3871	2	I	-PRON-	PRP
cord-006229-7yoilsho	3871	3	applied	apply	VBD
cord-006229-7yoilsho	3871	4	the	the	DT
cord-006229-7yoilsho	3871	5	criteria	criterion	NNS
cord-006229-7yoilsho	3871	6	for	for	IN
cord-006229-7yoilsho	3871	7	classification	classification	NN
cord-006229-7yoilsho	3871	8	and	and	CC
cord-006229-7yoilsho	3871	9	labelling	label	VBG
cord-006229-7yoilsho	3871	10	to	to	IN
cord-006229-7yoilsho	3871	11	a	a	DT
cord-006229-7yoilsho	3871	12	selection	selection	NN
cord-006229-7yoilsho	3871	13	of	of	IN
cord-006229-7yoilsho	3871	14	cosmetic	cosmetic	JJ
cord-006229-7yoilsho	3871	15	product	product	NN
cord-006229-7yoilsho	3871	16	formulas	formula	NNS
cord-006229-7yoilsho	3871	17	in	in	IN
cord-006229-7yoilsho	3871	18	a	a	DT
cord-006229-7yoilsho	3871	19	conservative	conservative	JJ
cord-006229-7yoilsho	3871	20	approach	approach	NN
cord-006229-7yoilsho	3871	21	,	,	,
cord-006229-7yoilsho	3871	22	most	most	JJS
cord-006229-7yoilsho	3871	23	products	product	NNS
cord-006229-7yoilsho	3871	24	would	would	MD
cord-006229-7yoilsho	3871	25	have	have	VB
cord-006229-7yoilsho	3871	26	to	to	TO
cord-006229-7yoilsho	3871	27	be	be	VB
cord-006229-7yoilsho	3871	28	labelled	label	VBN
cord-006229-7yoilsho	3871	29	and	and	CC
cord-006229-7yoilsho	3871	30	classified	classify	VBN
cord-006229-7yoilsho	3871	31	,	,	,
cord-006229-7yoilsho	3871	32	mainly	mainly	RB
cord-006229-7yoilsho	3871	33	due	due	IN
cord-006229-7yoilsho	3871	34	to	to	IN
cord-006229-7yoilsho	3871	35	hazardous	hazardous	JJ
cord-006229-7yoilsho	3871	36	effects	effect	NNS
cord-006229-7yoilsho	3871	37	to	to	IN
cord-006229-7yoilsho	3871	38	the	the	DT
cord-006229-7yoilsho	3871	39	eye	eye	NN
cord-006229-7yoilsho	3871	40	and	and	CC
cord-006229-7yoilsho	3871	41	to	to	IN
cord-006229-7yoilsho	3871	42	the	the	DT
cord-006229-7yoilsho	3871	43	skin	skin	NN
cord-006229-7yoilsho	3871	44	(	(	-LRB-
cord-006229-7yoilsho	3871	45	2	2	CD
cord-006229-7yoilsho	3871	46	)	)	-RRB-
cord-006229-7yoilsho	3871	47	.	.	.
cord-006229-7yoilsho	3872	1	Benefits	benefit	NNS
cord-006229-7yoilsho	3872	2	of	of	IN
cord-006229-7yoilsho	3872	3	personal	personal	JJ
cord-006229-7yoilsho	3872	4	care	care	NN
cord-006229-7yoilsho	3872	5	products	product	NNS
cord-006229-7yoilsho	3872	6	can	can	MD
cord-006229-7yoilsho	3872	7	go	go	VB
cord-006229-7yoilsho	3872	8	along	along	RB
cord-006229-7yoilsho	3872	9	with	with	IN
cord-006229-7yoilsho	3872	10	unwanted	unwanted	JJ
cord-006229-7yoilsho	3872	11	properties	property	NNS
cord-006229-7yoilsho	3872	12	such	such	JJ
cord-006229-7yoilsho	3872	13	as	as	IN
cord-006229-7yoilsho	3872	14	the	the	DT
cord-006229-7yoilsho	3872	15	hazards	hazard	NNS
cord-006229-7yoilsho	3872	16	for	for	IN
cord-006229-7yoilsho	3872	17	the	the	DT
cord-006229-7yoilsho	3872	18	human	human	JJ
cord-006229-7yoilsho	3872	19	health	health	NN
cord-006229-7yoilsho	3872	20	,	,	,
cord-006229-7yoilsho	3872	21	and	and	CC
cord-006229-7yoilsho	3872	22	consumers	consumer	NNS
cord-006229-7yoilsho	3872	23	should	should	MD
cord-006229-7yoilsho	3872	24	be	be	VB
cord-006229-7yoilsho	3872	25	informed	inform	VBN
cord-006229-7yoilsho	3872	26	about	about	IN
cord-006229-7yoilsho	3872	27	them	-PRON-	PRP
cord-006229-7yoilsho	3872	28	(	(	-LRB-
cord-006229-7yoilsho	3872	29	3	3	CD
cord-006229-7yoilsho	3872	30	)	)	-RRB-
cord-006229-7yoilsho	3872	31	.	.	.
cord-006229-7yoilsho	3873	1	Risk	risk	NN
cord-006229-7yoilsho	3873	2	communication	communication	NN
cord-006229-7yoilsho	3873	3	for	for	IN
cord-006229-7yoilsho	3873	4	every	every	DT
cord-006229-7yoilsho	3873	5	day	day	NN
cord-006229-7yoilsho	3873	6	products	product	NNS
cord-006229-7yoilsho	3873	7	like	like	IN
cord-006229-7yoilsho	3873	8	personal	personal	JJ
cord-006229-7yoilsho	3873	9	care	care	NN
cord-006229-7yoilsho	3873	10	products	product	NNS
cord-006229-7yoilsho	3873	11	should	should	MD
cord-006229-7yoilsho	3873	12	be	be	VB
cord-006229-7yoilsho	3873	13	clear	clear	JJ
cord-006229-7yoilsho	3873	14	,	,	,
cord-006229-7yoilsho	3873	15	easily	easily	RB
cord-006229-7yoilsho	3873	16	and	and	CC
cord-006229-7yoilsho	3873	17	quickly	quickly	RB
cord-006229-7yoilsho	3873	18	understandable	understandable	JJ
cord-006229-7yoilsho	3873	19	.	.	.
cord-006229-7yoilsho	3874	1	According	accord	VBG
cord-006229-7yoilsho	3874	2	to	to	IN
cord-006229-7yoilsho	3874	3	the	the	DT
cord-006229-7yoilsho	3874	4	cosmetic	cosmetic	JJ
cord-006229-7yoilsho	3874	5	regulation	regulation	NN
cord-006229-7yoilsho	3874	6	(	(	-LRB-
cord-006229-7yoilsho	3874	7	4	4	LS
cord-006229-7yoilsho	3874	8	)	)	-RRB-
cord-006229-7yoilsho	3874	9	the	the	DT
cord-006229-7yoilsho	3874	10	ingredients	ingredient	NNS
cord-006229-7yoilsho	3874	11	must	must	MD
cord-006229-7yoilsho	3874	12	be	be	VB
cord-006229-7yoilsho	3874	13	listed	list	VBN
cord-006229-7yoilsho	3874	14	on	on	IN
cord-006229-7yoilsho	3874	15	the	the	DT
cord-006229-7yoilsho	3874	16	containers	container	NNS
cord-006229-7yoilsho	3874	17	.	.	.
cord-006229-7yoilsho	3875	1	It	-PRON-	PRP
cord-006229-7yoilsho	3875	2	must	must	MD
cord-006229-7yoilsho	3875	3	be	be	VB
cord-006229-7yoilsho	3875	4	questioned	question	VBN
cord-006229-7yoilsho	3875	5	whether	whether	IN
cord-006229-7yoilsho	3875	6	the	the	DT
cord-006229-7yoilsho	3875	7	listing	listing	NN
cord-006229-7yoilsho	3875	8	of	of	IN
cord-006229-7yoilsho	3875	9	the	the	DT
cord-006229-7yoilsho	3875	10	ingredients	ingredient	NNS
cord-006229-7yoilsho	3875	11	without	without	IN
cord-006229-7yoilsho	3875	12	hazard	hazard	NN
cord-006229-7yoilsho	3875	13	pictograms	pictogram	NNS
cord-006229-7yoilsho	3875	14	on	on	IN
cord-006229-7yoilsho	3875	15	the	the	DT
cord-006229-7yoilsho	3875	16	products	product	NNS
cord-006229-7yoilsho	3875	17	could	could	MD
cord-006229-7yoilsho	3875	18	be	be	VB
cord-006229-7yoilsho	3875	19	considered	consider	VBN
cord-006229-7yoilsho	3875	20	as	as	IN
cord-006229-7yoilsho	3875	21	a	a	DT
cord-006229-7yoilsho	3875	22	clear	clear	JJ
cord-006229-7yoilsho	3875	23	,	,	,
cord-006229-7yoilsho	3875	24	easily	easily	RB
cord-006229-7yoilsho	3875	25	and	and	CC
cord-006229-7yoilsho	3875	26	quickly	quickly	RB
cord-006229-7yoilsho	3875	27	understandable	understandable	JJ
cord-006229-7yoilsho	3875	28	risk	risk	NN
cord-006229-7yoilsho	3875	29	communication	communication	NN
cord-006229-7yoilsho	3875	30	instrument	instrument	NN
cord-006229-7yoilsho	3875	31	(	(	-LRB-
cord-006229-7yoilsho	3875	32	3	3	CD
cord-006229-7yoilsho	3875	33	)	)	-RRB-
cord-006229-7yoilsho	3875	34	.	.	.
cord-006229-7yoilsho	3876	1	The	the	DT
cord-006229-7yoilsho	3876	2	results	result	NNS
cord-006229-7yoilsho	3876	3	show	show	VBP
cord-006229-7yoilsho	3876	4	that	that	IN
cord-006229-7yoilsho	3876	5	it	-PRON-	PRP
cord-006229-7yoilsho	3876	6	is	be	VBZ
cord-006229-7yoilsho	3876	7	urgent	urgent	JJ
cord-006229-7yoilsho	3876	8	to	to	TO
cord-006229-7yoilsho	3876	9	inform	inform	VB
cord-006229-7yoilsho	3876	10	consumers	consumer	NNS
cord-006229-7yoilsho	3876	11	better	well	JJR
cord-006229-7yoilsho	3876	12	about	about	IN
cord-006229-7yoilsho	3876	13	the	the	DT
cord-006229-7yoilsho	3876	14	potential	potential	JJ
cord-006229-7yoilsho	3876	15	dangers	danger	NNS
cord-006229-7yoilsho	3876	16	of	of	IN
cord-006229-7yoilsho	3876	17	personal	personal	JJ
cord-006229-7yoilsho	3876	18	care	care	NN
cord-006229-7yoilsho	3876	19	products	product	NNS
cord-006229-7yoilsho	3876	20	,	,	,
cord-006229-7yoilsho	3876	21	because	because	IN
cord-006229-7yoilsho	3876	22	cosmetics	cosmetic	NNS
cord-006229-7yoilsho	3876	23	need	need	VBP
cord-006229-7yoilsho	3876	24	to	to	TO
cord-006229-7yoilsho	3876	25	be	be	VB
cord-006229-7yoilsho	3876	26	applied	apply	VBN
cord-006229-7yoilsho	3876	27	even	even	RB
cord-006229-7yoilsho	3876	28	with	with	IN
cord-006229-7yoilsho	3876	29	more	more	JJR
cord-006229-7yoilsho	3876	30	care	care	NN
cord-006229-7yoilsho	3876	31	than	than	IN
cord-006229-7yoilsho	3876	32	any	any	DT
cord-006229-7yoilsho	3876	33	other	other	JJ
cord-006229-7yoilsho	3876	34	consumer	consumer	NN
cord-006229-7yoilsho	3876	35	product	product	NN
cord-006229-7yoilsho	3876	36	.	.	.
cord-006229-7yoilsho	3877	1	It	-PRON-	PRP
cord-006229-7yoilsho	3877	2	is	be	VBZ
cord-006229-7yoilsho	3877	3	strongly	strongly	RB
cord-006229-7yoilsho	3877	4	recommended	recommend	VBN
cord-006229-7yoilsho	3877	5	to	to	TO
cord-006229-7yoilsho	3877	6	delete	delete	VB
cord-006229-7yoilsho	3877	7	the	the	DT
cord-006229-7yoilsho	3877	8	exception	exception	NN
cord-006229-7yoilsho	3877	9	provision	provision	NN
cord-006229-7yoilsho	3877	10	in	in	IN
cord-006229-7yoilsho	3877	11	the	the	DT
cord-006229-7yoilsho	3877	12	CLP	CLP	NNP
cord-006229-7yoilsho	3877	13	regulation	regulation	NN
cord-006229-7yoilsho	3877	14	for	for	IN
cord-006229-7yoilsho	3877	15	personal	personal	JJ
cord-006229-7yoilsho	3877	16	care	care	NN
cord-006229-7yoilsho	3877	17	products	product	NNS
cord-006229-7yoilsho	3877	18	.	.	.
cord-006229-7yoilsho	3878	1	The	the	DT
cord-006229-7yoilsho	3878	2	infochemical	infochemical	JJ
cord-006229-7yoilsho	3878	3	effect	effect	NN
cord-006229-7yoilsho	3878	4	describes	describe	VBZ
cord-006229-7yoilsho	3878	5	that	that	IN
cord-006229-7yoilsho	3878	6	anthropogenic	anthropogenic	JJ
cord-006229-7yoilsho	3878	7	substances	substance	NNS
cord-006229-7yoilsho	3878	8	can	can	MD
cord-006229-7yoilsho	3878	9	interfere	interfere	VB
cord-006229-7yoilsho	3878	10	with	with	IN
cord-006229-7yoilsho	3878	11	the	the	DT
cord-006229-7yoilsho	3878	12	chemical	chemical	JJ
cord-006229-7yoilsho	3878	13	communication	communication	NN
cord-006229-7yoilsho	3878	14	and	and	CC
cord-006229-7yoilsho	3878	15	influence	influence	NN
cord-006229-7yoilsho	3878	16	organisms	organism	NNS
cord-006229-7yoilsho	3878	17	so	so	IN
cord-006229-7yoilsho	3878	18	that	that	IN
cord-006229-7yoilsho	3878	19	they	-PRON-	PRP
cord-006229-7yoilsho	3878	20	perceive	perceive	VBP
cord-006229-7yoilsho	3878	21	their	-PRON-	PRP$
cord-006229-7yoilsho	3878	22	chemical	chemical	NN
cord-006229-7yoilsho	3878	23	environments	environment	NNS
cord-006229-7yoilsho	3878	24	differently	differently	RB
cord-006229-7yoilsho	3878	25	(	(	-LRB-
cord-006229-7yoilsho	3878	26	1,2	1,2	CD
cord-006229-7yoilsho	3878	27	)	)	-RRB-
cord-006229-7yoilsho	3878	28	.	.	.
cord-006229-7yoilsho	3879	1	Infochemicals	infochemical	NNS
cord-006229-7yoilsho	3879	2	play	play	VBP
cord-006229-7yoilsho	3879	3	a	a	DT
cord-006229-7yoilsho	3879	4	role	role	NN
cord-006229-7yoilsho	3879	5	in	in	IN
cord-006229-7yoilsho	3879	6	life	life	NN
cord-006229-7yoilsho	3879	7	history	history	NN
cord-006229-7yoilsho	3879	8	,	,	,
cord-006229-7yoilsho	3879	9	habitat	habitat	NN
cord-006229-7yoilsho	3879	10	search	search	NN
cord-006229-7yoilsho	3879	11	,	,	,
cord-006229-7yoilsho	3879	12	food	food	NN
cord-006229-7yoilsho	3879	13	related	relate	VBN
cord-006229-7yoilsho	3879	14	aspects	aspect	NNS
cord-006229-7yoilsho	3879	15	and	and	CC
cord-006229-7yoilsho	3879	16	survival	survival	NN
cord-006229-7yoilsho	3879	17	which	which	WDT
cord-006229-7yoilsho	3879	18	shows	show	VBZ
cord-006229-7yoilsho	3879	19	that	that	IN
cord-006229-7yoilsho	3879	20	disturbed	disturbed	JJ
cord-006229-7yoilsho	3879	21	communication	communication	NN
cord-006229-7yoilsho	3879	22	(	(	-LRB-
cord-006229-7yoilsho	3879	23	infodisruption	infodisruption	NN
cord-006229-7yoilsho	3879	24	)	)	-RRB-
cord-006229-7yoilsho	3879	25	could	could	MD
cord-006229-7yoilsho	3879	26	affect	affect	VB
cord-006229-7yoilsho	3879	27	population	population	NN
cord-006229-7yoilsho	3879	28	vulnerability	vulnerability	NN
cord-006229-7yoilsho	3879	29	at	at	IN
cord-006229-7yoilsho	3879	30	various	various	JJ
cord-006229-7yoilsho	3879	31	decisive	decisive	JJ
cord-006229-7yoilsho	3879	32	points	point	NNS
cord-006229-7yoilsho	3879	33	(	(	-LRB-
cord-006229-7yoilsho	3879	34	3	3	CD
cord-006229-7yoilsho	3879	35	)	)	-RRB-
cord-006229-7yoilsho	3879	36	.	.	.
cord-006229-7yoilsho	3880	1	The	the	DT
cord-006229-7yoilsho	3880	2	classical	classical	JJ
cord-006229-7yoilsho	3880	3	ecotoxicological	ecotoxicological	JJ
cord-006229-7yoilsho	3880	4	standard	standard	JJ
cord-006229-7yoilsho	3880	5	tests	test	NNS
cord-006229-7yoilsho	3880	6	do	do	VBP
cord-006229-7yoilsho	3880	7	not	not	RB
cord-006229-7yoilsho	3880	8	allow	allow	VB
cord-006229-7yoilsho	3880	9	to	to	TO
cord-006229-7yoilsho	3880	10	observe	observe	VB
cord-006229-7yoilsho	3880	11	the	the	DT
cord-006229-7yoilsho	3880	12	infochemical	infochemical	JJ
cord-006229-7yoilsho	3880	13	effect	effect	NN
cord-006229-7yoilsho	3880	14	.	.	.
cord-006229-7yoilsho	3881	1	Systematic	systematic	JJ
cord-006229-7yoilsho	3881	2	analyses	analysis	NNS
cord-006229-7yoilsho	3881	3	are	be	VBP
cord-006229-7yoilsho	3881	4	needed	need	VBN
cord-006229-7yoilsho	3881	5	to	to	TO
cord-006229-7yoilsho	3881	6	find	find	VB
cord-006229-7yoilsho	3881	7	out	out	RP
cord-006229-7yoilsho	3881	8	more	more	JJR
cord-006229-7yoilsho	3881	9	about	about	IN
cord-006229-7yoilsho	3881	10	the	the	DT
cord-006229-7yoilsho	3881	11	relevance	relevance	NN
cord-006229-7yoilsho	3881	12	of	of	IN
cord-006229-7yoilsho	3881	13	this	this	DT
cord-006229-7yoilsho	3881	14	new	new	JJ
cord-006229-7yoilsho	3881	15	chapter	chapter	NN
cord-006229-7yoilsho	3881	16	in	in	IN
cord-006229-7yoilsho	3881	17	ecotoxicology	ecotoxicology	NN
cord-006229-7yoilsho	3881	18	for	for	IN
cord-006229-7yoilsho	3881	19	natural	natural	JJ
cord-006229-7yoilsho	3881	20	ecosystems	ecosystem	NNS
cord-006229-7yoilsho	3881	21	.	.	.
cord-006229-7yoilsho	3882	1	The	the	DT
cord-006229-7yoilsho	3882	2	first	first	JJ
cord-006229-7yoilsho	3882	3	crucial	crucial	JJ
cord-006229-7yoilsho	3882	4	step	step	NN
cord-006229-7yoilsho	3882	5	is	be	VBZ
cord-006229-7yoilsho	3882	6	to	to	TO
cord-006229-7yoilsho	3882	7	select	select	VB
cord-006229-7yoilsho	3882	8	suitable	suitable	JJ
cord-006229-7yoilsho	3882	9	test	test	NN
cord-006229-7yoilsho	3882	10	substances	substance	NNS
cord-006229-7yoilsho	3882	11	.	.	.
cord-006229-7yoilsho	3883	1	Repellents	repellent	NNS
cord-006229-7yoilsho	3883	2	(	(	-LRB-
cord-006229-7yoilsho	3883	3	substances	substance	NNS
cord-006229-7yoilsho	3883	4	used	use	VBN
cord-006229-7yoilsho	3883	5	to	to	TO
cord-006229-7yoilsho	3883	6	keep	keep	VB
cord-006229-7yoilsho	3883	7	away	away	RB
cord-006229-7yoilsho	3883	8	target	target	NN
cord-006229-7yoilsho	3883	9	organisms	organism	NNS
cord-006229-7yoilsho	3883	10	,	,	,
cord-006229-7yoilsho	3883	11	e.g.	e.g.	RB
cord-006229-7yoilsho	3883	12	invertebrates	invertebrate	NNS
cord-006229-7yoilsho	3883	13	such	such	JJ
cord-006229-7yoilsho	3883	14	as	as	IN
cord-006229-7yoilsho	3883	15	midges	midge	NNS
cord-006229-7yoilsho	3883	16	or	or	CC
cord-006229-7yoilsho	3883	17	fleas	flea	NNS
cord-006229-7yoilsho	3883	18	via	via	IN
cord-006229-7yoilsho	3883	19	olfaction	olfaction	NN
cord-006229-7yoilsho	3883	20	)	)	-RRB-
cord-006229-7yoilsho	3883	21	enter	enter	VB
cord-006229-7yoilsho	3883	22	surface	surface	NN
cord-006229-7yoilsho	3883	23	waters	water	NNS
cord-006229-7yoilsho	3883	24	mainly	mainly	RB
cord-006229-7yoilsho	3883	25	indirectly	indirectly	RB
cord-006229-7yoilsho	3883	26	via	via	IN
cord-006229-7yoilsho	3883	27	wastewater	wastewater	NN
cord-006229-7yoilsho	3883	28	discharges	discharge	NNS
cord-006229-7yoilsho	3883	29	from	from	IN
cord-006229-7yoilsho	3883	30	sewage	sewage	NN
cord-006229-7yoilsho	3883	31	treatment	treatment	NN
cord-006229-7yoilsho	3883	32	plants	plant	NNS
cord-006229-7yoilsho	3883	33	or	or	CC
cord-006229-7yoilsho	3883	34	directly	directly	RB
cord-006229-7yoilsho	3883	35	by	by	IN
cord-006229-7yoilsho	3883	36	being	be	VBG
cord-006229-7yoilsho	3883	37	washed	wash	VBN
cord-006229-7yoilsho	3883	38	off	off	RP
cord-006229-7yoilsho	3883	39	from	from	IN
cord-006229-7yoilsho	3883	40	the	the	DT
cord-006229-7yoilsho	3883	41	skin	skin	NN
cord-006229-7yoilsho	3883	42	and	and	CC
cord-006229-7yoilsho	3883	43	clothes	clothe	NNS
cord-006229-7yoilsho	3883	44	of	of	IN
cord-006229-7yoilsho	3883	45	bathers	bather	NNS
cord-006229-7yoilsho	3883	46	.	.	.
cord-006229-7yoilsho	3884	1	There	there	EX
cord-006229-7yoilsho	3884	2	are	be	VBP
cord-006229-7yoilsho	3884	3	various	various	JJ
cord-006229-7yoilsho	3884	4	indications	indication	NNS
cord-006229-7yoilsho	3884	5	that	that	IN
cord-006229-7yoilsho	3884	6	repellents	repellent	NNS
cord-006229-7yoilsho	3884	7	which	which	WDT
cord-006229-7yoilsho	3884	8	are	be	VBP
cord-006229-7yoilsho	3884	9	not	not	RB
cord-006229-7yoilsho	3884	10	toxic	toxic	JJ
cord-006229-7yoilsho	3884	11	for	for	IN
cord-006229-7yoilsho	3884	12	aquatic	aquatic	JJ
cord-006229-7yoilsho	3884	13	animals	animal	NNS
cord-006229-7yoilsho	3884	14	could	could	MD
cord-006229-7yoilsho	3884	15	induce	induce	VB
cord-006229-7yoilsho	3884	16	effects	effect	NNS
cord-006229-7yoilsho	3884	17	like	like	IN
cord-006229-7yoilsho	3884	18	organismic	organismic	JJ
cord-006229-7yoilsho	3884	19	downstream	downstream	JJ
cord-006229-7yoilsho	3884	20	drift	drift	NN
cord-006229-7yoilsho	3884	21	of	of	IN
cord-006229-7yoilsho	3884	22	non	non	JJ
cord-006229-7yoilsho	3884	23	-	-	JJ
cord-006229-7yoilsho	3884	24	target	target	JJ
cord-006229-7yoilsho	3884	25	species	specie	NNS
cord-006229-7yoilsho	3884	26	(	(	-LRB-
cord-006229-7yoilsho	3884	27	downstream	downstream	JJ
cord-006229-7yoilsho	3884	28	dislocation	dislocation	NN
cord-006229-7yoilsho	3884	29	of	of	IN
cord-006229-7yoilsho	3884	30	e.g.	e.g.	JJ
cord-006229-7yoilsho	3884	31	crustacean	crustacean	NN
cord-006229-7yoilsho	3884	32	and	and	CC
cord-006229-7yoilsho	3884	33	insect	insect	NN
cord-006229-7yoilsho	3884	34	larvae	larva	NNS
cord-006229-7yoilsho	3884	35	in	in	IN
cord-006229-7yoilsho	3884	36	streams	stream	NNS
cord-006229-7yoilsho	3884	37	)	)	-RRB-
cord-006229-7yoilsho	3884	38	.	.	.
cord-006229-7yoilsho	3885	1	In	in	IN
cord-006229-7yoilsho	3885	2	a	a	DT
cord-006229-7yoilsho	3885	3	literature	literature	NN
cord-006229-7yoilsho	3885	4	study	study	NN
cord-006229-7yoilsho	3885	5	,	,	,
cord-006229-7yoilsho	3885	6	three	three	CD
cord-006229-7yoilsho	3885	7	repellents	repellent	NNS
cord-006229-7yoilsho	3885	8	were	be	VBD
cord-006229-7yoilsho	3885	9	identified	identify	VBN
cord-006229-7yoilsho	3885	10	to	to	TO
cord-006229-7yoilsho	3885	11	be	be	VB
cord-006229-7yoilsho	3885	12	suitable	suitable	JJ
cord-006229-7yoilsho	3885	13	test	test	NN
cord-006229-7yoilsho	3885	14	compounds	compound	NNS
cord-006229-7yoilsho	3885	15	for	for	IN
cord-006229-7yoilsho	3885	16	proof	proof	NN
cord-006229-7yoilsho	3885	17	of	of	IN
cord-006229-7yoilsho	3885	18	concept	concept	NN
cord-006229-7yoilsho	3885	19	of	of	IN
cord-006229-7yoilsho	3885	20	the	the	DT
cord-006229-7yoilsho	3885	21	infochemical	infochemical	JJ
cord-006229-7yoilsho	3885	22	effect	effect	NN
cord-006229-7yoilsho	3885	23	.	.	.
cord-006229-7yoilsho	3886	1	DEET	DEET	NNP
cord-006229-7yoilsho	3886	2	(	(	-LRB-
cord-006229-7yoilsho	3886	3	CAS	CAS	NNP
cord-006229-7yoilsho	3886	4	134	134	CD
cord-006229-7yoilsho	3886	5	-	-	HYPH
cord-006229-7yoilsho	3886	6	62	62	CD
cord-006229-7yoilsho	3886	7	-	-	SYM
cord-006229-7yoilsho	3886	8	3	3	CD
cord-006229-7yoilsho	3886	9	)	)	-RRB-
cord-006229-7yoilsho	3886	10	,	,	,
cord-006229-7yoilsho	3886	11	Icaridine	Icaridine	NNP
cord-006229-7yoilsho	3886	12	(	(	-LRB-
cord-006229-7yoilsho	3886	13	CAS	CAS	NNP
cord-006229-7yoilsho	3886	14	119515	119515	CD
cord-006229-7yoilsho	3886	15	-	-	HYPH
cord-006229-7yoilsho	3886	16	38	38	CD
cord-006229-7yoilsho	3886	17	-	-	SYM
cord-006229-7yoilsho	3886	18	7	7	CD
cord-006229-7yoilsho	3886	19	)	)	-RRB-
cord-006229-7yoilsho	3886	20	and	and	CC
cord-006229-7yoilsho	3886	21	EBAAP	EBAAP	NNP
cord-006229-7yoilsho	3886	22	(	(	-LRB-
cord-006229-7yoilsho	3886	23	CAS	CAS	NNP
cord-006229-7yoilsho	3886	24	52304	52304	CD
cord-006229-7yoilsho	3886	25	-	-	SYM
cord-006229-7yoilsho	3886	26	36	36	CD
cord-006229-7yoilsho	3886	27	-	-	SYM
cord-006229-7yoilsho	3886	28	6	6	CD
cord-006229-7yoilsho	3886	29	)	)	-RRB-
cord-006229-7yoilsho	3886	30	(	(	-LRB-
cord-006229-7yoilsho	3886	31	4	4	LS
cord-006229-7yoilsho	3886	32	)	)	-RRB-
cord-006229-7yoilsho	3886	33	.	.	.
cord-006229-7yoilsho	3887	1	These	these	DT
cord-006229-7yoilsho	3887	2	substances	substance	NNS
cord-006229-7yoilsho	3887	3	are	be	VBP
cord-006229-7yoilsho	3887	4	investigated	investigate	VBN
cord-006229-7yoilsho	3887	5	in	in	IN
cord-006229-7yoilsho	3887	6	new	new	JJ
cord-006229-7yoilsho	3887	7	test	test	NN
cord-006229-7yoilsho	3887	8	designs	design	NNS
cord-006229-7yoilsho	3887	9	in	in	IN
cord-006229-7yoilsho	3887	10	a	a	DT
cord-006229-7yoilsho	3887	11	subsequent	subsequent	JJ
cord-006229-7yoilsho	3887	12	experimental	experimental	JJ
cord-006229-7yoilsho	3887	13	part	part	NN
cord-006229-7yoilsho	3887	14	of	of	IN
cord-006229-7yoilsho	3887	15	the	the	DT
cord-006229-7yoilsho	3887	16	project	project	NN
cord-006229-7yoilsho	3887	17	which	which	WDT
cord-006229-7yoilsho	3887	18	are	be	VBP
cord-006229-7yoilsho	3887	19	designed	design	VBN
cord-006229-7yoilsho	3887	20	to	to	TO
cord-006229-7yoilsho	3887	21	detect	detect	VB
cord-006229-7yoilsho	3887	22	and	and	CC
cord-006229-7yoilsho	3887	23	quantify	quantify	VB
cord-006229-7yoilsho	3887	24	the	the	DT
cord-006229-7yoilsho	3887	25	infochemical	infochemical	JJ
cord-006229-7yoilsho	3887	26	effect	effect	NN
cord-006229-7yoilsho	3887	27	.	.	.
cord-006229-7yoilsho	3888	1	Persistent	persistent	JJ
cord-006229-7yoilsho	3888	2	,	,	,
cord-006229-7yoilsho	3888	3	bioaccumulative	bioaccumulative	JJ
cord-006229-7yoilsho	3888	4	and	and	CC
cord-006229-7yoilsho	3888	5	toxic	toxic	JJ
cord-006229-7yoilsho	3888	6	(	(	-LRB-
cord-006229-7yoilsho	3888	7	PBT	PBT	NNP
cord-006229-7yoilsho	3888	8	)	)	-RRB-
cord-006229-7yoilsho	3888	9	substances	substance	NNS
cord-006229-7yoilsho	3888	10	or	or	CC
cord-006229-7yoilsho	3888	11	very	very	RB
cord-006229-7yoilsho	3888	12	persistent	persistent	JJ
cord-006229-7yoilsho	3888	13	and	and	CC
cord-006229-7yoilsho	3888	14	very	very	RB
cord-006229-7yoilsho	3888	15	bioaccumulative	bioaccumulative	JJ
cord-006229-7yoilsho	3888	16	(	(	-LRB-
cord-006229-7yoilsho	3888	17	vPvB	vpvb	NN
cord-006229-7yoilsho	3888	18	)	)	-RRB-
cord-006229-7yoilsho	3888	19	substances	substance	NNS
cord-006229-7yoilsho	3888	20	are	be	VBP
cord-006229-7yoilsho	3888	21	compounds	compound	NNS
cord-006229-7yoilsho	3888	22	with	with	IN
cord-006229-7yoilsho	3888	23	hazardous	hazardous	JJ
cord-006229-7yoilsho	3888	24	properties	property	NNS
cord-006229-7yoilsho	3888	25	.	.	.
cord-006229-7yoilsho	3889	1	The	the	DT
cord-006229-7yoilsho	3889	2	non	non	JJ
cord-006229-7yoilsho	3889	3	-	-	JJ
cord-006229-7yoilsho	3889	4	biodegradability	biodegradability	JJ
cord-006229-7yoilsho	3889	5	(	(	-LRB-
cord-006229-7yoilsho	3889	6	persistence	persistence	NN
cord-006229-7yoilsho	3889	7	)	)	-RRB-
cord-006229-7yoilsho	3889	8	and	and	CC
cord-006229-7yoilsho	3889	9	high	high	JJ
cord-006229-7yoilsho	3889	10	accumulation	accumulation	NN
cord-006229-7yoilsho	3889	11	in	in	IN
cord-006229-7yoilsho	3889	12	organisms	organism	NNS
cord-006229-7yoilsho	3889	13	(	(	-LRB-
cord-006229-7yoilsho	3889	14	bioaccumulation	bioaccumulation	NN
cord-006229-7yoilsho	3889	15	)	)	-RRB-
cord-006229-7yoilsho	3889	16	may	may	MD
cord-006229-7yoilsho	3889	17	elicit	elicit	VB
cord-006229-7yoilsho	3889	18	long	long	JJ
cord-006229-7yoilsho	3889	19	-	-	HYPH
cord-006229-7yoilsho	3889	20	term	term	NN
cord-006229-7yoilsho	3889	21	adverse	adverse	JJ
cord-006229-7yoilsho	3889	22	effects	effect	NNS
cord-006229-7yoilsho	3889	23	in	in	IN
cord-006229-7yoilsho	3889	24	the	the	DT
cord-006229-7yoilsho	3889	25	environment	environment	NN
cord-006229-7yoilsho	3889	26	.	.	.
cord-006229-7yoilsho	3890	1	Persistent	persistent	JJ
cord-006229-7yoilsho	3890	2	and	and	CC
cord-006229-7yoilsho	3890	3	bioaccumulative	bioaccumulative	JJ
cord-006229-7yoilsho	3890	4	substances	substance	NNS
cord-006229-7yoilsho	3890	5	concentrate	concentrate	VBP
cord-006229-7yoilsho	3890	6	in	in	IN
cord-006229-7yoilsho	3890	7	the	the	DT
cord-006229-7yoilsho	3890	8	environmental	environmental	JJ
cord-006229-7yoilsho	3890	9	compartments	compartment	NNS
cord-006229-7yoilsho	3890	10	(	(	-LRB-
cord-006229-7yoilsho	3890	11	water	water	NN
cord-006229-7yoilsho	3890	12	,	,	,
cord-006229-7yoilsho	3890	13	sediment	sediment	NN
cord-006229-7yoilsho	3890	14	,	,	,
cord-006229-7yoilsho	3890	15	soil	soil	NN
cord-006229-7yoilsho	3890	16	,	,	,
cord-006229-7yoilsho	3890	17	air	air	NN
cord-006229-7yoilsho	3890	18	)	)	-RRB-
cord-006229-7yoilsho	3890	19	and	and	CC
cord-006229-7yoilsho	3890	20	can	can	MD
cord-006229-7yoilsho	3890	21	be	be	VB
cord-006229-7yoilsho	3890	22	distributed	distribute	VBN
cord-006229-7yoilsho	3890	23	in	in	IN
cord-006229-7yoilsho	3890	24	the	the	DT
cord-006229-7yoilsho	3890	25	food	food	NN
cord-006229-7yoilsho	3890	26	chains	chain	NNS
cord-006229-7yoilsho	3890	27	.	.	.
cord-006229-7yoilsho	3891	1	Ecotoxicological	ecotoxicological	JJ
cord-006229-7yoilsho	3891	2	effects	effect	NNS
cord-006229-7yoilsho	3891	3	are	be	VBP
cord-006229-7yoilsho	3891	4	strengthened	strengthen	VBN
cord-006229-7yoilsho	3891	5	by	by	IN
cord-006229-7yoilsho	3891	6	bioaccumulation	bioaccumulation	NN
cord-006229-7yoilsho	3891	7	and	and	CC
cord-006229-7yoilsho	3891	8	appear	appear	VBP
cord-006229-7yoilsho	3891	9	often	often	RB
cord-006229-7yoilsho	3891	10	in	in	IN
cord-006229-7yoilsho	3891	11	remote	remote	JJ
cord-006229-7yoilsho	3891	12	areas	area	NNS
cord-006229-7yoilsho	3891	13	like	like	IN
cord-006229-7yoilsho	3891	14	marine	marine	JJ
cord-006229-7yoilsho	3891	15	and	and	CC
cord-006229-7yoilsho	3891	16	polar	polar	JJ
cord-006229-7yoilsho	3891	17	regions	region	NNS
cord-006229-7yoilsho	3891	18	.	.	.
cord-006229-7yoilsho	3892	1	In	in	IN
cord-006229-7yoilsho	3892	2	the	the	DT
cord-006229-7yoilsho	3892	3	framework	framework	NN
cord-006229-7yoilsho	3892	4	of	of	IN
cord-006229-7yoilsho	3892	5	PBT	PBT	NNP
cord-006229-7yoilsho	3892	6	assessment	assessment	NN
cord-006229-7yoilsho	3892	7	,	,	,
cord-006229-7yoilsho	3892	8	contrary	contrary	JJ
cord-006229-7yoilsho	3892	9	to	to	IN
cord-006229-7yoilsho	3892	10	the	the	DT
cord-006229-7yoilsho	3892	11	risk	risk	NN
cord-006229-7yoilsho	3892	12	assessment	assessment	NN
cord-006229-7yoilsho	3892	13	,	,	,
cord-006229-7yoilsho	3892	14	the	the	DT
cord-006229-7yoilsho	3892	15	substances	substance	NNS
cord-006229-7yoilsho	3892	16	are	be	VBP
cord-006229-7yoilsho	3892	17	evaluated	evaluate	VBN
cord-006229-7yoilsho	3892	18	regardless	regardless	RB
cord-006229-7yoilsho	3892	19	of	of	IN
cord-006229-7yoilsho	3892	20	the	the	DT
cord-006229-7yoilsho	3892	21	emission	emission	NN
cord-006229-7yoilsho	3892	22	into	into	IN
cord-006229-7yoilsho	3892	23	the	the	DT
cord-006229-7yoilsho	3892	24	environment	environment	NN
cord-006229-7yoilsho	3892	25	.	.	.
cord-006229-7yoilsho	3893	1	An	an	DT
cord-006229-7yoilsho	3893	2	evaluation	evaluation	NN
cord-006229-7yoilsho	3893	3	of	of	IN
cord-006229-7yoilsho	3893	4	medicinal	medicinal	JJ
cord-006229-7yoilsho	3893	5	active	active	JJ
cord-006229-7yoilsho	3893	6	ingredients	ingredient	NNS
cord-006229-7yoilsho	3893	7	under	under	IN
cord-006229-7yoilsho	3893	8	assessment	assessment	NN
cord-006229-7yoilsho	3893	9	in	in	IN
cord-006229-7yoilsho	3893	10	the	the	DT
cord-006229-7yoilsho	3893	11	German	german	JJ
cord-006229-7yoilsho	3893	12	federal	federal	JJ
cord-006229-7yoilsho	3893	13	environment	environment	NN
cord-006229-7yoilsho	3893	14	agency	agency	NN
cord-006229-7yoilsho	3893	15	(	(	-LRB-
cord-006229-7yoilsho	3893	16	UBA	UBA	NNP
cord-006229-7yoilsho	3893	17	)	)	-RRB-
cord-006229-7yoilsho	3893	18	identified	identify	VBD
cord-006229-7yoilsho	3893	19	less	less	JJR
cord-006229-7yoilsho	3893	20	than	than	IN
cord-006229-7yoilsho	3893	21	10	10	CD
cord-006229-7yoilsho	3893	22	%	%	NN
cord-006229-7yoilsho	3893	23	as	as	IN
cord-006229-7yoilsho	3893	24	potential	potential	JJ
cord-006229-7yoilsho	3893	25	PBT	PBT	NNP
cord-006229-7yoilsho	3893	26	candidates	candidate	NNS
cord-006229-7yoilsho	3893	27	.	.	.
cord-006229-7yoilsho	3894	1	Due	due	IN
cord-006229-7yoilsho	3894	2	to	to	IN
cord-006229-7yoilsho	3894	3	data	datum	NNS
cord-006229-7yoilsho	3894	4	lacks	lack	VBZ
cord-006229-7yoilsho	3894	5	in	in	IN
cord-006229-7yoilsho	3894	6	many	many	JJ
cord-006229-7yoilsho	3894	7	cases	case	NNS
cord-006229-7yoilsho	3894	8	a	a	DT
cord-006229-7yoilsho	3894	9	definite	definite	JJ
cord-006229-7yoilsho	3894	10	PBT	PBT	NNP
cord-006229-7yoilsho	3894	11	classification	classification	NN
cord-006229-7yoilsho	3894	12	is	be	VBZ
cord-006229-7yoilsho	3894	13	not	not	RB
cord-006229-7yoilsho	3894	14	possible	possible	JJ
cord-006229-7yoilsho	3894	15	.	.	.
cord-006229-7yoilsho	3895	1	The	the	DT
cord-006229-7yoilsho	3895	2	poster	poster	NN
cord-006229-7yoilsho	3895	3	presents	present	VBZ
cord-006229-7yoilsho	3895	4	results	result	NNS
cord-006229-7yoilsho	3895	5	of	of	IN
cord-006229-7yoilsho	3895	6	an	an	DT
cord-006229-7yoilsho	3895	7	extensive	extensive	JJ
cord-006229-7yoilsho	3895	8	literature	literature	NN
cord-006229-7yoilsho	3895	9	research	research	NN
cord-006229-7yoilsho	3895	10	on	on	IN
cord-006229-7yoilsho	3895	11	the	the	DT
cord-006229-7yoilsho	3895	12	global	global	JJ
cord-006229-7yoilsho	3895	13	occurrence	occurrence	NN
cord-006229-7yoilsho	3895	14	of	of	IN
cord-006229-7yoilsho	3895	15	pharmaceuticals	pharmaceutical	NNS
cord-006229-7yoilsho	3895	16	in	in	IN
cord-006229-7yoilsho	3895	17	the	the	DT
cord-006229-7yoilsho	3895	18	environment	environment	NN
cord-006229-7yoilsho	3895	19	.	.	.
cord-006229-7yoilsho	3896	1	Data	datum	NNS
cord-006229-7yoilsho	3896	2	on	on	IN
cord-006229-7yoilsho	3896	3	measured	measure	VBN
cord-006229-7yoilsho	3896	4	environmental	environmental	JJ
cord-006229-7yoilsho	3896	5	occurrences	occurrence	NNS
cord-006229-7yoilsho	3896	6	from	from	IN
cord-006229-7yoilsho	3896	7	more	more	JJR
cord-006229-7yoilsho	3896	8	than	than	IN
cord-006229-7yoilsho	3896	9	1,000	1,000	CD
cord-006229-7yoilsho	3896	10	international	international	JJ
cord-006229-7yoilsho	3896	11	publications	publication	NNS
cord-006229-7yoilsho	3896	12	have	have	VBP
cord-006229-7yoilsho	3896	13	been	be	VBN
cord-006229-7yoilsho	3896	14	transferred	transfer	VBN
cord-006229-7yoilsho	3896	15	to	to	IN
cord-006229-7yoilsho	3896	16	a	a	DT
cord-006229-7yoilsho	3896	17	database	database	NN
cord-006229-7yoilsho	3896	18	,	,	,
cord-006229-7yoilsho	3896	19	with	with	IN
cord-006229-7yoilsho	3896	20	more	more	JJR
cord-006229-7yoilsho	3896	21	than	than	IN
cord-006229-7yoilsho	3896	22	120,000	120,000	CD
cord-006229-7yoilsho	3896	23	entries	entry	NNS
cord-006229-7yoilsho	3896	24	.	.	.
cord-006229-7yoilsho	3897	1	According	accord	VBG
cord-006229-7yoilsho	3897	2	to	to	IN
cord-006229-7yoilsho	3897	3	the	the	DT
cord-006229-7yoilsho	3897	4	database	database	NN
cord-006229-7yoilsho	3897	5	,	,	,
cord-006229-7yoilsho	3897	6	pharmaceuticals	pharmaceutical	NNS
cord-006229-7yoilsho	3897	7	have	have	VBP
cord-006229-7yoilsho	3897	8	been	be	VBN
cord-006229-7yoilsho	3897	9	found	find	VBN
cord-006229-7yoilsho	3897	10	in	in	IN
cord-006229-7yoilsho	3897	11	the	the	DT
cord-006229-7yoilsho	3897	12	environment	environment	NN
cord-006229-7yoilsho	3897	13	of	of	IN
cord-006229-7yoilsho	3897	14	71	71	CD
cord-006229-7yoilsho	3897	15	countries	country	NNS
cord-006229-7yoilsho	3897	16	worldwide	worldwide	RB
cord-006229-7yoilsho	3897	17	in	in	IN
cord-006229-7yoilsho	3897	18	all	all	DT
cord-006229-7yoilsho	3897	19	five	five	CD
cord-006229-7yoilsho	3897	20	UN	UN	NNP
cord-006229-7yoilsho	3897	21	regions	region	NNS
cord-006229-7yoilsho	3897	22	.	.	.
cord-006229-7yoilsho	3898	1	Most	Most	JJS
cord-006229-7yoilsho	3898	2	published	publish	VBN
cord-006229-7yoilsho	3898	3	data	datum	NNS
cord-006229-7yoilsho	3898	4	are	be	VBP
cord-006229-7yoilsho	3898	5	for	for	IN
cord-006229-7yoilsho	3898	6	the	the	DT
cord-006229-7yoilsho	3898	7	compartments	compartment	NNS
cord-006229-7yoilsho	3898	8	surface	surface	NN
cord-006229-7yoilsho	3898	9	water	water	NN
cord-006229-7yoilsho	3898	10	and	and	CC
cord-006229-7yoilsho	3898	11	sewage	sewage	NN
cord-006229-7yoilsho	3898	12	effluent	effluent	NN
cord-006229-7yoilsho	3898	13	;	;	:
cord-006229-7yoilsho	3898	14	less	less	JJR
cord-006229-7yoilsho	3898	15	information	information	NN
cord-006229-7yoilsho	3898	16	is	be	VBZ
cord-006229-7yoilsho	3898	17	available	available	JJ
cord-006229-7yoilsho	3898	18	for	for	IN
cord-006229-7yoilsho	3898	19	groundwater	groundwater	NN
cord-006229-7yoilsho	3898	20	,	,	,
cord-006229-7yoilsho	3898	21	manure	manure	NN
cord-006229-7yoilsho	3898	22	,	,	,
cord-006229-7yoilsho	3898	23	soil	soil	NN
cord-006229-7yoilsho	3898	24	,	,	,
cord-006229-7yoilsho	3898	25	and	and	CC
cord-006229-7yoilsho	3898	26	other	other	JJ
cord-006229-7yoilsho	3898	27	environmental	environmental	JJ
cord-006229-7yoilsho	3898	28	matrices	matrix	NNS
cord-006229-7yoilsho	3898	29	.	.	.
cord-006229-7yoilsho	3899	1	More	More	JJR
cord-006229-7yoilsho	3899	2	than	than	IN
cord-006229-7yoilsho	3899	3	600	600	CD
cord-006229-7yoilsho	3899	4	active	active	JJ
cord-006229-7yoilsho	3899	5	pharmaceutical	pharmaceutical	JJ
cord-006229-7yoilsho	3899	6	substances	substance	NNS
cord-006229-7yoilsho	3899	7	(	(	-LRB-
cord-006229-7yoilsho	3899	8	or	or	CC
cord-006229-7yoilsho	3899	9	their	-PRON-	PRP$
cord-006229-7yoilsho	3899	10	metabolites	metabolite	NNS
cord-006229-7yoilsho	3899	11	and	and	CC
cord-006229-7yoilsho	3899	12	transformation	transformation	NN
cord-006229-7yoilsho	3899	13	products	product	NNS
cord-006229-7yoilsho	3899	14	)	)	-RRB-
cord-006229-7yoilsho	3899	15	have	have	VBP
cord-006229-7yoilsho	3899	16	been	be	VBN
cord-006229-7yoilsho	3899	17	detected	detect	VBN
cord-006229-7yoilsho	3899	18	in	in	IN
cord-006229-7yoilsho	3899	19	the	the	DT
cord-006229-7yoilsho	3899	20	environment	environment	NN
cord-006229-7yoilsho	3899	21	.	.	.
cord-006229-7yoilsho	3900	1	Most	Most	JJS
cord-006229-7yoilsho	3900	2	findings	finding	NNS
cord-006229-7yoilsho	3900	3	have	have	VBP
cord-006229-7yoilsho	3900	4	been	be	VBN
cord-006229-7yoilsho	3900	5	published	publish	VBN
cord-006229-7yoilsho	3900	6	for	for	IN
cord-006229-7yoilsho	3900	7	industrialized	industrialized	JJ
cord-006229-7yoilsho	3900	8	countries	country	NNS
cord-006229-7yoilsho	3900	9	.	.	.
cord-006229-7yoilsho	3901	1	Monitoring	monitoring	NN
cord-006229-7yoilsho	3901	2	campaigns	campaign	NNS
cord-006229-7yoilsho	3901	3	are	be	VBP
cord-006229-7yoilsho	3901	4	increasingly	increasingly	RB
cord-006229-7yoilsho	3901	5	being	be	VBG
cord-006229-7yoilsho	3901	6	conducted	conduct	VBN
cord-006229-7yoilsho	3901	7	in	in	IN
cord-006229-7yoilsho	3901	8	developing	develop	VBG
cord-006229-7yoilsho	3901	9	and	and	CC
cord-006229-7yoilsho	3901	10	emerging	emerge	VBG
cord-006229-7yoilsho	3901	11	countries	country	NNS
cord-006229-7yoilsho	3901	12	.	.	.
cord-006229-7yoilsho	3902	1	These	these	DT
cord-006229-7yoilsho	3902	2	have	have	VBP
cord-006229-7yoilsho	3902	3	revealed	reveal	VBN
cord-006229-7yoilsho	3902	4	the	the	DT
cord-006229-7yoilsho	3902	5	global	global	JJ
cord-006229-7yoilsho	3902	6	scale	scale	NN
cord-006229-7yoilsho	3902	7	of	of	IN
cord-006229-7yoilsho	3902	8	the	the	DT
cord-006229-7yoilsho	3902	9	occurrence	occurrence	NN
cord-006229-7yoilsho	3902	10	of	of	IN
cord-006229-7yoilsho	3902	11	pharmaceuticals	pharmaceutical	NNS
cord-006229-7yoilsho	3902	12	in	in	IN
cord-006229-7yoilsho	3902	13	the	the	DT
cord-006229-7yoilsho	3902	14	environment	environment	NN
cord-006229-7yoilsho	3902	15	.	.	.
cord-006229-7yoilsho	3903	1	For	for	IN
cord-006229-7yoilsho	3903	2	example	example	NN
cord-006229-7yoilsho	3903	3	,	,	,
cord-006229-7yoilsho	3903	4	diclofenac	diclofenac	NNP
cord-006229-7yoilsho	3903	5	,	,	,
cord-006229-7yoilsho	3903	6	a	a	DT
cord-006229-7yoilsho	3903	7	non	non	JJ
cord-006229-7yoilsho	3903	8	-	-	JJ
cord-006229-7yoilsho	3903	9	steroidal	steroidal	JJ
cord-006229-7yoilsho	3903	10	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	3903	11	drug	drug	NN
cord-006229-7yoilsho	3903	12	,	,	,
cord-006229-7yoilsho	3903	13	has	have	VBZ
cord-006229-7yoilsho	3903	14	been	be	VBN
cord-006229-7yoilsho	3903	15	detected	detect	VBN
cord-006229-7yoilsho	3903	16	in	in	IN
cord-006229-7yoilsho	3903	17	the	the	DT
cord-006229-7yoilsho	3903	18	aquatic	aquatic	JJ
cord-006229-7yoilsho	3903	19	environment	environment	NN
cord-006229-7yoilsho	3903	20	in	in	IN
cord-006229-7yoilsho	3903	21	50	50	CD
cord-006229-7yoilsho	3903	22	countries	country	NNS
cord-006229-7yoilsho	3903	23	worldwide	worldwide	RB
cord-006229-7yoilsho	3903	24	.	.	.
cord-006229-7yoilsho	3904	1	A	a	DT
cord-006229-7yoilsho	3904	2	number	number	NN
cord-006229-7yoilsho	3904	3	of	of	IN
cord-006229-7yoilsho	3904	4	globally	globally	RB
cord-006229-7yoilsho	3904	5	marketed	market	VBN
cord-006229-7yoilsho	3904	6	pharmaceuticals	pharmaceutical	NNS
cord-006229-7yoilsho	3904	7	have	have	VBP
cord-006229-7yoilsho	3904	8	been	be	VBN
cord-006229-7yoilsho	3904	9	found	find	VBN
cord-006229-7yoilsho	3904	10	in	in	IN
cord-006229-7yoilsho	3904	11	both	both	DT
cord-006229-7yoilsho	3904	12	developing	develop	VBG
cord-006229-7yoilsho	3904	13	and	and	CC
cord-006229-7yoilsho	3904	14	industrialized	industrialized	JJ
cord-006229-7yoilsho	3904	15	countries	country	NNS
cord-006229-7yoilsho	3904	16	.	.	.
cord-006229-7yoilsho	3905	1	The	the	DT
cord-006229-7yoilsho	3905	2	available	available	JJ
cord-006229-7yoilsho	3905	3	ecotoxicological	ecotoxicological	JJ
cord-006229-7yoilsho	3905	4	information	information	NN
cord-006229-7yoilsho	3905	5	indicates	indicate	VBZ
cord-006229-7yoilsho	3905	6	that	that	IN
cord-006229-7yoilsho	3905	7	certain	certain	JJ
cord-006229-7yoilsho	3905	8	pharmaceuticals	pharmaceutical	NNS
cord-006229-7yoilsho	3905	9	pose	pose	VBP
cord-006229-7yoilsho	3905	10	a	a	DT
cord-006229-7yoilsho	3905	11	risk	risk	NN
cord-006229-7yoilsho	3905	12	to	to	IN
cord-006229-7yoilsho	3905	13	the	the	DT
cord-006229-7yoilsho	3905	14	environment	environment	NN
cord-006229-7yoilsho	3905	15	at	at	IN
cord-006229-7yoilsho	3905	16	measured	measure	VBN
cord-006229-7yoilsho	3905	17	concentrations	concentration	NNS
cord-006229-7yoilsho	3905	18	.	.	.
cord-006229-7yoilsho	3906	1	Options	option	NNS
cord-006229-7yoilsho	3906	2	for	for	IN
cord-006229-7yoilsho	3906	3	cooperative	cooperative	JJ
cord-006229-7yoilsho	3906	4	action	action	NN
cord-006229-7yoilsho	3906	5	to	to	TO
cord-006229-7yoilsho	3906	6	address	address	VB
cord-006229-7yoilsho	3906	7	the	the	DT
cord-006229-7yoilsho	3906	8	risk	risk	NN
cord-006229-7yoilsho	3906	9	of	of	IN
cord-006229-7yoilsho	3906	10	are	be	VBP
cord-006229-7yoilsho	3906	11	also	also	RB
cord-006229-7yoilsho	3906	12	presented	present	VBN
cord-006229-7yoilsho	3906	13	.	.	.
cord-006229-7yoilsho	3907	1	The	the	DT
cord-006229-7yoilsho	3907	2	aim	aim	NN
cord-006229-7yoilsho	3907	3	of	of	IN
cord-006229-7yoilsho	3907	4	the	the	DT
cord-006229-7yoilsho	3907	5	research	research	NN
cord-006229-7yoilsho	3907	6	presented	present	VBN
cord-006229-7yoilsho	3907	7	was	be	VBD
cord-006229-7yoilsho	3907	8	to	to	TO
cord-006229-7yoilsho	3907	9	support	support	VB
cord-006229-7yoilsho	3907	10	the	the	DT
cord-006229-7yoilsho	3907	11	discussion	discussion	NN
cord-006229-7yoilsho	3907	12	of	of	IN
cord-006229-7yoilsho	3907	13	the	the	DT
cord-006229-7yoilsho	3907	14	proposed	propose	VBN
cord-006229-7yoilsho	3907	15	emerging	emerge	VBG
cord-006229-7yoilsho	3907	16	policy	policy	NN
cord-006229-7yoilsho	3907	17	issue	issue	NN
cord-006229-7yoilsho	3907	18	pharmaceuticals	pharmaceutical	NNS
cord-006229-7yoilsho	3907	19	in	in	IN
cord-006229-7yoilsho	3907	20	the	the	DT
cord-006229-7yoilsho	3907	21	environment	environment	NN
cord-006229-7yoilsho	3907	22	under	under	IN
cord-006229-7yoilsho	3907	23	the	the	DT
cord-006229-7yoilsho	3907	24	Strategic	Strategic	NNP
cord-006229-7yoilsho	3907	25	Approach	Approach	NNP
cord-006229-7yoilsho	3907	26	to	to	IN
cord-006229-7yoilsho	3907	27	International	International	NNP
cord-006229-7yoilsho	3907	28	Chemicals	Chemicals	NNPS
cord-006229-7yoilsho	3907	29	Management	Management	NNP
cord-006229-7yoilsho	3907	30	(	(	-LRB-
cord-006229-7yoilsho	3907	31	SAICM	SAICM	NNP
cord-006229-7yoilsho	3907	32	)	)	-RRB-
cord-006229-7yoilsho	3907	33	,	,	,
cord-006229-7yoilsho	3907	34	which	which	WDT
cord-006229-7yoilsho	3907	35	is	be	VBZ
cord-006229-7yoilsho	3907	36	a	a	DT
cord-006229-7yoilsho	3907	37	global	global	JJ
cord-006229-7yoilsho	3907	38	initiative	initiative	NN
cord-006229-7yoilsho	3907	39	of	of	IN
cord-006229-7yoilsho	3907	40	United	United	NNP
cord-006229-7yoilsho	3907	41	Nation	Nation	NNP
cord-006229-7yoilsho	3907	42	Environment	Environment	NNP
cord-006229-7yoilsho	3907	43	Programme	Programme	NNP
cord-006229-7yoilsho	3907	44	(	(	-LRB-
cord-006229-7yoilsho	3907	45	UNEP	UNEP	NNP
cord-006229-7yoilsho	3907	46	)	)	-RRB-
cord-006229-7yoilsho	3907	47	.	.	.
cord-006229-7yoilsho	3908	1	The	the	DT
cord-006229-7yoilsho	3908	2	European	european	JJ
cord-006229-7yoilsho	3908	3	chemicals	chemical	NNS
cord-006229-7yoilsho	3908	4	'	'	POS
cord-006229-7yoilsho	3908	5	legislation	legislation	NN
cord-006229-7yoilsho	3908	6	REACH	reach	VBP
cord-006229-7yoilsho	3908	7	aims	aim	VBZ
cord-006229-7yoilsho	3908	8	to	to	TO
cord-006229-7yoilsho	3908	9	protect	protect	VB
cord-006229-7yoilsho	3908	10	man	man	NN
cord-006229-7yoilsho	3908	11	and	and	CC
cord-006229-7yoilsho	3908	12	the	the	DT
cord-006229-7yoilsho	3908	13	environment	environment	NN
cord-006229-7yoilsho	3908	14	from	from	IN
cord-006229-7yoilsho	3908	15	substances	substance	NNS
cord-006229-7yoilsho	3908	16	of	of	IN
cord-006229-7yoilsho	3908	17	very	very	RB
cord-006229-7yoilsho	3908	18	high	high	JJ
cord-006229-7yoilsho	3908	19	concern	concern	NN
cord-006229-7yoilsho	3908	20	(	(	-LRB-
cord-006229-7yoilsho	3908	21	SVHC	SVHC	NNP
cord-006229-7yoilsho	3908	22	)	)	-RRB-
cord-006229-7yoilsho	3908	23	.	.	.
cord-006229-7yoilsho	3909	1	Chemicals	chemical	NNS
cord-006229-7yoilsho	3909	2	with	with	IN
cord-006229-7yoilsho	3909	3	(	(	-LRB-
cord-006229-7yoilsho	3909	4	very	very	RB
cord-006229-7yoilsho	3909	5	)	)	-RRB-
cord-006229-7yoilsho	3909	6	persistent	persistent	JJ
cord-006229-7yoilsho	3909	7	,	,	,
cord-006229-7yoilsho	3909	8	(	(	-LRB-
cord-006229-7yoilsho	3909	9	very	very	RB
cord-006229-7yoilsho	3909	10	)	)	-RRB-
cord-006229-7yoilsho	3909	11	bioaccumulative	bioaccumulative	JJ
cord-006229-7yoilsho	3909	12	and	and	CC
cord-006229-7yoilsho	3909	13	toxic	toxic	JJ
cord-006229-7yoilsho	3909	14	properties	property	NNS
cord-006229-7yoilsho	3910	1	(	(	-LRB-
cord-006229-7yoilsho	3910	2	PBT	PBT	NNP
cord-006229-7yoilsho	3910	3	and	and	CC
cord-006229-7yoilsho	3910	4	vPvB	vpvb	NN
cord-006229-7yoilsho	3910	5	compounds	compound	NNS
cord-006229-7yoilsho	3910	6	)	)	-RRB-
cord-006229-7yoilsho	3910	7	,	,	,
cord-006229-7yoilsho	3910	8	substances	substance	NNS
cord-006229-7yoilsho	3910	9	that	that	WDT
cord-006229-7yoilsho	3910	10	are	be	VBP
cord-006229-7yoilsho	3910	11	carcinogenic	carcinogenic	JJ
cord-006229-7yoilsho	3910	12	,	,	,
cord-006229-7yoilsho	3910	13	mutagenic	mutagenic	JJ
cord-006229-7yoilsho	3910	14	and	and	CC
cord-006229-7yoilsho	3910	15	toxic	toxic	JJ
cord-006229-7yoilsho	3910	16	to	to	IN
cord-006229-7yoilsho	3910	17	reproduction	reproduction	NN
cord-006229-7yoilsho	3910	18	(	(	-LRB-
cord-006229-7yoilsho	3910	19	CMR	CMR	NNP
cord-006229-7yoilsho	3910	20	compounds	compound	NNS
cord-006229-7yoilsho	3910	21	)	)	-RRB-
cord-006229-7yoilsho	3910	22	,	,	,
cord-006229-7yoilsho	3910	23	as	as	RB
cord-006229-7yoilsho	3910	24	well	well	RB
cord-006229-7yoilsho	3910	25	as	as	IN
cord-006229-7yoilsho	3910	26	chemicals	chemical	NNS
cord-006229-7yoilsho	3910	27	of	of	IN
cord-006229-7yoilsho	3910	28	comparable	comparable	JJ
cord-006229-7yoilsho	3910	29	concern	concern	NN
cord-006229-7yoilsho	3910	30	like	like	IN
cord-006229-7yoilsho	3910	31	endocrine	endocrine	JJ
cord-006229-7yoilsho	3910	32	disruptors	disruptor	NNS
cord-006229-7yoilsho	3910	33	(	(	-LRB-
cord-006229-7yoilsho	3910	34	EDs	EDs	NNP
cord-006229-7yoilsho	3910	35	)	)	-RRB-
cord-006229-7yoilsho	3910	36	may	may	MD
cord-006229-7yoilsho	3910	37	be	be	VB
cord-006229-7yoilsho	3910	38	subject	subject	JJ
cord-006229-7yoilsho	3910	39	to	to	IN
cord-006229-7yoilsho	3910	40	authorization	authorization	NN
cord-006229-7yoilsho	3910	41	.	.	.
cord-006229-7yoilsho	3911	1	The	the	DT
cord-006229-7yoilsho	3911	2	identification	identification	NN
cord-006229-7yoilsho	3911	3	of	of	IN
cord-006229-7yoilsho	3911	4	EDs	EDs	NNP
cord-006229-7yoilsho	3911	5	is	be	VBZ
cord-006229-7yoilsho	3911	6	limited	limit	VBN
cord-006229-7yoilsho	3911	7	as	as	IN
cord-006229-7yoilsho	3911	8	yet	yet	RB
cord-006229-7yoilsho	3911	9	,	,	,
cord-006229-7yoilsho	3911	10	because	because	IN
cord-006229-7yoilsho	3911	11	specific	specific	JJ
cord-006229-7yoilsho	3911	12	experimental	experimental	JJ
cord-006229-7yoilsho	3911	13	assessments	assessment	NNS
cord-006229-7yoilsho	3911	14	are	be	VBP
cord-006229-7yoilsho	3911	15	not	not	RB
cord-006229-7yoilsho	3911	16	required	require	VBN
cord-006229-7yoilsho	3911	17	under	under	IN
cord-006229-7yoilsho	3911	18	REACH	reach	NN
cord-006229-7yoilsho	3911	19	.	.	.
cord-006229-7yoilsho	3912	1	Evidence	evidence	NN
cord-006229-7yoilsho	3912	2	is	be	VBZ
cord-006229-7yoilsho	3912	3	currently	currently	RB
cord-006229-7yoilsho	3912	4	based	base	VBN
cord-006229-7yoilsho	3912	5	on	on	IN
cord-006229-7yoilsho	3912	6	a	a	DT
cord-006229-7yoilsho	3912	7	combination	combination	NN
cord-006229-7yoilsho	3912	8	of	of	IN
cord-006229-7yoilsho	3912	9	few	few	JJ
cord-006229-7yoilsho	3912	10	experiments	experiment	NNS
cord-006229-7yoilsho	3912	11	,	,	,
cord-006229-7yoilsho	3912	12	expert	expert	JJ
cord-006229-7yoilsho	3912	13	judgement	judgement	NN
cord-006229-7yoilsho	3912	14	and	and	CC
cord-006229-7yoilsho	3912	15	structural	structural	JJ
cord-006229-7yoilsho	3912	16	analogy	analogy	NN
cord-006229-7yoilsho	3912	17	with	with	IN
cord-006229-7yoilsho	3912	18	known	know	VBN
cord-006229-7yoilsho	3912	19	EDs	EDs	NNP
cord-006229-7yoilsho	3912	20	.	.	.
cord-006229-7yoilsho	3913	1	Structural	structural	JJ
cord-006229-7yoilsho	3913	2	alerts	alert	NNS
cord-006229-7yoilsho	3913	3	for	for	IN
cord-006229-7yoilsho	3913	4	the	the	DT
cord-006229-7yoilsho	3913	5	identification	identification	NN
cord-006229-7yoilsho	3913	6	of	of	IN
cord-006229-7yoilsho	3913	7	potential	potential	JJ
cord-006229-7yoilsho	3913	8	EDs	ed	NNS
cord-006229-7yoilsho	3913	9	:	:	:
cord-006229-7yoilsho	3913	10	Predictions	prediction	NNS
cord-006229-7yoilsho	3913	11	of	of	IN
cord-006229-7yoilsho	3913	12	properties	property	NNS
cord-006229-7yoilsho	3913	13	and	and	CC
cord-006229-7yoilsho	3913	14	effects	effect	NNS
cord-006229-7yoilsho	3913	15	from	from	IN
cord-006229-7yoilsho	3913	16	chemical	chemical	JJ
cord-006229-7yoilsho	3913	17	structures	structure	NNS
cord-006229-7yoilsho	3913	18	are	be	VBP
cord-006229-7yoilsho	3913	19	based	base	VBN
cord-006229-7yoilsho	3913	20	on	on	IN
cord-006229-7yoilsho	3913	21	similarities	similarity	NNS
cord-006229-7yoilsho	3913	22	with	with	IN
cord-006229-7yoilsho	3913	23	either	either	CC
cord-006229-7yoilsho	3913	24	active	active	JJ
cord-006229-7yoilsho	3913	25	or	or	CC
cord-006229-7yoilsho	3913	26	inactive	inactive	JJ
cord-006229-7yoilsho	3913	27	substances	substance	NNS
cord-006229-7yoilsho	3913	28	.	.	.
cord-006229-7yoilsho	3914	1	Structural	structural	JJ
cord-006229-7yoilsho	3914	2	alerts	alert	NNS
cord-006229-7yoilsho	3914	3	for	for	IN
cord-006229-7yoilsho	3914	4	the	the	DT
cord-006229-7yoilsho	3914	5	identification	identification	NN
cord-006229-7yoilsho	3914	6	of	of	IN
cord-006229-7yoilsho	3914	7	potential	potential	JJ
cord-006229-7yoilsho	3914	8	estrogen	estrogen	NN
cord-006229-7yoilsho	3914	9	/	/	SYM
cord-006229-7yoilsho	3914	10	androgen	androgen	NN
cord-006229-7yoilsho	3914	11	-	-	HYPH
cord-006229-7yoilsho	3914	12	ED	ED	NNP
cord-006229-7yoilsho	3914	13	activities	activity	NNS
cord-006229-7yoilsho	3914	14	are	be	VBP
cord-006229-7yoilsho	3914	15	relevant	relevant	JJ
cord-006229-7yoilsho	3914	16	parts	part	NNS
cord-006229-7yoilsho	3914	17	of	of	IN
cord-006229-7yoilsho	3914	18	the	the	DT
cord-006229-7yoilsho	3914	19	structures	structure	NNS
cord-006229-7yoilsho	3914	20	of	of	IN
cord-006229-7yoilsho	3914	21	compounds	compound	NNS
cord-006229-7yoilsho	3914	22	that	that	WDT
cord-006229-7yoilsho	3914	23	are	be	VBP
cord-006229-7yoilsho	3914	24	known	know	VBN
cord-006229-7yoilsho	3914	25	to	to	TO
cord-006229-7yoilsho	3914	26	interact	interact	VB
cord-006229-7yoilsho	3914	27	with	with	IN
cord-006229-7yoilsho	3914	28	estrogen	estrogen	NN
cord-006229-7yoilsho	3914	29	and	and	CC
cord-006229-7yoilsho	3914	30	androgen	androgen	NN
cord-006229-7yoilsho	3914	31	receptors	receptor	NNS
cord-006229-7yoilsho	3914	32	as	as	IN
cord-006229-7yoilsho	3914	33	either	either	CC
cord-006229-7yoilsho	3914	34	agonists	agonist	NNS
cord-006229-7yoilsho	3914	35	or	or	CC
cord-006229-7yoilsho	3914	36	antagonists	antagonist	NNS
cord-006229-7yoilsho	3914	37	.	.	.
cord-006229-7yoilsho	3915	1	In	in	IN
cord-006229-7yoilsho	3915	2	addition	addition	NN
cord-006229-7yoilsho	3915	3	to	to	IN
cord-006229-7yoilsho	3915	4	the	the	DT
cord-006229-7yoilsho	3915	5	backbones	backbone	NNS
cord-006229-7yoilsho	3915	6	of	of	IN
cord-006229-7yoilsho	3915	7	the	the	DT
cord-006229-7yoilsho	3915	8	chemical	chemical	JJ
cord-006229-7yoilsho	3915	9	structures	structure	NNS
cord-006229-7yoilsho	3915	10	(	(	-LRB-
cord-006229-7yoilsho	3915	11	pharmacophore	pharmacophore	NNP
cord-006229-7yoilsho	3915	12	)	)	-RRB-
cord-006229-7yoilsho	3915	13	for	for	IN
cord-006229-7yoilsho	3915	14	steric	steric	JJ
cord-006229-7yoilsho	3915	15	fit	fit	JJ
cord-006229-7yoilsho	3915	16	to	to	IN
cord-006229-7yoilsho	3915	17	the	the	DT
cord-006229-7yoilsho	3915	18	receptors	receptor	NNS
cord-006229-7yoilsho	3915	19	,	,	,
cord-006229-7yoilsho	3915	20	modulating	modulate	VBG
cord-006229-7yoilsho	3915	21	factors	factor	NNS
cord-006229-7yoilsho	3915	22	may	may	MD
cord-006229-7yoilsho	3915	23	be	be	VB
cord-006229-7yoilsho	3915	24	small	small	JJ
cord-006229-7yoilsho	3915	25	substructures	substructure	NNS
cord-006229-7yoilsho	3915	26	for	for	IN
cord-006229-7yoilsho	3915	27	local	local	JJ
cord-006229-7yoilsho	3915	28	interactions	interaction	NNS
cord-006229-7yoilsho	3915	29	with	with	IN
cord-006229-7yoilsho	3915	30	receptor	receptor	NN
cord-006229-7yoilsho	3915	31	binding	bind	VBG
cord-006229-7yoilsho	3915	32	sites	site	NNS
cord-006229-7yoilsho	3915	33	and	and	CC
cord-006229-7yoilsho	3915	34	physicochemical	physicochemical	JJ
cord-006229-7yoilsho	3915	35	properties	property	NNS
cord-006229-7yoilsho	3915	36	related	relate	VBN
cord-006229-7yoilsho	3915	37	to	to	IN
cord-006229-7yoilsho	3915	38	the	the	DT
cord-006229-7yoilsho	3915	39	strength	strength	NN
cord-006229-7yoilsho	3915	40	of	of	IN
cord-006229-7yoilsho	3915	41	binding	bind	VBG
cord-006229-7yoilsho	3915	42	to	to	IN
cord-006229-7yoilsho	3915	43	the	the	DT
cord-006229-7yoilsho	3915	44	receptor	receptor	NN
cord-006229-7yoilsho	3915	45	.	.	.
cord-006229-7yoilsho	3916	1	Comparison	comparison	NN
cord-006229-7yoilsho	3916	2	of	of	IN
cord-006229-7yoilsho	3916	3	evidence	evidence	NN
cord-006229-7yoilsho	3916	4	from	from	IN
cord-006229-7yoilsho	3916	5	in	in	IN
cord-006229-7yoilsho	3916	6	silico	silico	NN
cord-006229-7yoilsho	3916	7	,	,	,
cord-006229-7yoilsho	3916	8	in	in	IN
cord-006229-7yoilsho	3916	9	vitro	vitro	FW
cord-006229-7yoilsho	3916	10	and	and	CC
cord-006229-7yoilsho	3916	11	in	in	IN
cord-006229-7yoilsho	3916	12	vivo	vivo	FW
cord-006229-7yoilsho	3916	13	assays	assay	NNS
cord-006229-7yoilsho	3916	14	for	for	IN
cord-006229-7yoilsho	3916	15	potential	potential	JJ
cord-006229-7yoilsho	3916	16	EDs	EDs	NNP
cord-006229-7yoilsho	3916	17	:	:	:
cord-006229-7yoilsho	3916	18	Identification	identification	NN
cord-006229-7yoilsho	3916	19	of	of	IN
cord-006229-7yoilsho	3916	20	potential	potential	JJ
cord-006229-7yoilsho	3916	21	EDs	EDs	NNP
cord-006229-7yoilsho	3916	22	based	base	VBN
cord-006229-7yoilsho	3916	23	on	on	IN
cord-006229-7yoilsho	3916	24	findings	finding	NNS
cord-006229-7yoilsho	3916	25	from	from	IN
cord-006229-7yoilsho	3916	26	mammalian	mammalian	JJ
cord-006229-7yoilsho	3916	27	long	long	JJ
cord-006229-7yoilsho	3916	28	-	-	HYPH
cord-006229-7yoilsho	3916	29	term	term	NN
cord-006229-7yoilsho	3916	30	reproduction	reproduction	NN
cord-006229-7yoilsho	3916	31	studies	study	NNS
cord-006229-7yoilsho	3916	32	,	,	,
cord-006229-7yoilsho	3916	33	fish	fish	VB
cord-006229-7yoilsho	3916	34	life	life	NN
cord-006229-7yoilsho	3916	35	-	-	HYPH
cord-006229-7yoilsho	3916	36	cycle	cycle	NN
cord-006229-7yoilsho	3916	37	tests	test	NNS
cord-006229-7yoilsho	3916	38	,	,	,
cord-006229-7yoilsho	3916	39	receptor	receptor	NN
cord-006229-7yoilsho	3916	40	assays	assay	NNS
cord-006229-7yoilsho	3916	41	,	,	,
cord-006229-7yoilsho	3916	42	and	and	CC
cord-006229-7yoilsho	3916	43	chemical	chemical	NN
cord-006229-7yoilsho	3916	44	alerts	alert	NNS
cord-006229-7yoilsho	3916	45	were	be	VBD
cord-006229-7yoilsho	3916	46	compared	compare	VBN
cord-006229-7yoilsho	3916	47	and	and	CC
cord-006229-7yoilsho	3916	48	differences	difference	NNS
cord-006229-7yoilsho	3916	49	analysed	analyse	VBD
cord-006229-7yoilsho	3916	50	.	.	.
cord-006229-7yoilsho	3917	1	Agreement	agreement	NN
cord-006229-7yoilsho	3917	2	is	be	VBZ
cord-006229-7yoilsho	3917	3	limited	limit	VBN
cord-006229-7yoilsho	3917	4	because	because	IN
cord-006229-7yoilsho	3917	5	in	in	IN
cord-006229-7yoilsho	3917	6	vivo	vivo	NN
cord-006229-7yoilsho	3917	7	,	,	,
cord-006229-7yoilsho	3917	8	in	in	IN
cord-006229-7yoilsho	3917	9	vitro	vitro	FW
cord-006229-7yoilsho	3917	10	and	and	CC
cord-006229-7yoilsho	3917	11	in	in	IN
cord-006229-7yoilsho	3917	12	silico	silico	NN
cord-006229-7yoilsho	3917	13	methods	method	NNS
cord-006229-7yoilsho	3917	14	address	address	VBP
cord-006229-7yoilsho	3917	15	different	different	JJ
cord-006229-7yoilsho	3917	16	aspects	aspect	NNS
cord-006229-7yoilsho	3917	17	of	of	IN
cord-006229-7yoilsho	3917	18	potential	potential	JJ
cord-006229-7yoilsho	3917	19	effects	effect	NNS
cord-006229-7yoilsho	3917	20	on	on	IN
cord-006229-7yoilsho	3917	21	endocrine	endocrine	JJ
cord-006229-7yoilsho	3917	22	systems	system	NNS
cord-006229-7yoilsho	3917	23	regarding	regard	VBG
cord-006229-7yoilsho	3917	24	toxicological	toxicological	JJ
cord-006229-7yoilsho	3917	25	targets	target	NNS
cord-006229-7yoilsho	3917	26	,	,	,
cord-006229-7yoilsho	3917	27	modes	mode	NNS
cord-006229-7yoilsho	3917	28	of	of	IN
cord-006229-7yoilsho	3917	29	action	action	NN
cord-006229-7yoilsho	3917	30	and	and	CC
cord-006229-7yoilsho	3917	31	functional	functional	JJ
cord-006229-7yoilsho	3917	32	similarity	similarity	NN
cord-006229-7yoilsho	3917	33	of	of	IN
cord-006229-7yoilsho	3917	34	chemical	chemical	JJ
cord-006229-7yoilsho	3917	35	structures	structure	NNS
cord-006229-7yoilsho	3917	36	.	.	.
cord-006229-7yoilsho	3918	1	A	a	DT
cord-006229-7yoilsho	3918	2	combination	combination	NN
cord-006229-7yoilsho	3918	3	of	of	IN
cord-006229-7yoilsho	3918	4	toxicological	toxicological	JJ
cord-006229-7yoilsho	3918	5	and	and	CC
cord-006229-7yoilsho	3918	6	chemical	chemical	JJ
cord-006229-7yoilsho	3918	7	assays	assay	NNS
cord-006229-7yoilsho	3918	8	can	can	MD
cord-006229-7yoilsho	3918	9	provide	provide	VB
cord-006229-7yoilsho	3918	10	comprehensive	comprehensive	JJ
cord-006229-7yoilsho	3918	11	and	and	CC
cord-006229-7yoilsho	3918	12	complementary	complementary	JJ
cord-006229-7yoilsho	3918	13	information	information	NN
cord-006229-7yoilsho	3918	14	to	to	TO
cord-006229-7yoilsho	3918	15	support	support	VB
cord-006229-7yoilsho	3918	16	evidence	evidence	NN
cord-006229-7yoilsho	3918	17	-	-	HYPH
cord-006229-7yoilsho	3918	18	based	base	VBN
cord-006229-7yoilsho	3918	19	identification	identification	NN
cord-006229-7yoilsho	3918	20	of	of	IN
cord-006229-7yoilsho	3918	21	potential	potential	JJ
cord-006229-7yoilsho	3918	22	EDs	ed	NNS
cord-006229-7yoilsho	3918	23	among	among	IN
cord-006229-7yoilsho	3918	24	the	the	DT
cord-006229-7yoilsho	3918	25	chemicals	chemical	NNS
cord-006229-7yoilsho	3918	26	released	release	VBN
cord-006229-7yoilsho	3918	27	into	into	IN
cord-006229-7yoilsho	3918	28	the	the	DT
cord-006229-7yoilsho	3918	29	environment	environment	NN
cord-006229-7yoilsho	3918	30	.	.	.
cord-006229-7yoilsho	3919	1	Application	application	NN
cord-006229-7yoilsho	3919	2	of	of	IN
cord-006229-7yoilsho	3919	3	structural	structural	JJ
cord-006229-7yoilsho	3919	4	alerts	alert	NNS
cord-006229-7yoilsho	3919	5	for	for	IN
cord-006229-7yoilsho	3919	6	the	the	DT
cord-006229-7yoilsho	3919	7	identification	identification	NN
cord-006229-7yoilsho	3919	8	of	of	IN
cord-006229-7yoilsho	3919	9	potential	potential	JJ
cord-006229-7yoilsho	3919	10	EDs	EDs	NNP
cord-006229-7yoilsho	3919	11	to	to	IN
cord-006229-7yoilsho	3919	12	the	the	DT
cord-006229-7yoilsho	3919	13	EINECS	EINECS	NNP
cord-006229-7yoilsho	3919	14	inventory	inventory	NN
cord-006229-7yoilsho	3919	15	:	:	:
cord-006229-7yoilsho	3919	16	More	More	JJR
cord-006229-7yoilsho	3919	17	than	than	IN
cord-006229-7yoilsho	3919	18	33000	33000	CD
cord-006229-7yoilsho	3919	19	discrete	discrete	JJ
cord-006229-7yoilsho	3919	20	organic	organic	JJ
cord-006229-7yoilsho	3919	21	EINECS	EINECS	NNP
cord-006229-7yoilsho	3919	22	compounds	compound	NNS
cord-006229-7yoilsho	3919	23	are	be	VBP
cord-006229-7yoilsho	3919	24	within	within	IN
cord-006229-7yoilsho	3919	25	the	the	DT
cord-006229-7yoilsho	3919	26	applicability	applicability	NN
cord-006229-7yoilsho	3919	27	domain	domain	NN
cord-006229-7yoilsho	3919	28	of	of	IN
cord-006229-7yoilsho	3919	29	the	the	DT
cord-006229-7yoilsho	3919	30	structural	structural	JJ
cord-006229-7yoilsho	3919	31	alerts	alert	NNS
cord-006229-7yoilsho	3919	32	for	for	IN
cord-006229-7yoilsho	3919	33	potential	potential	JJ
cord-006229-7yoilsho	3919	34	estrogen	estrogen	NN
cord-006229-7yoilsho	3919	35	/	/	SYM
cord-006229-7yoilsho	3919	36	androgen	androgen	NN
cord-006229-7yoilsho	3919	37	-	-	HYPH
cord-006229-7yoilsho	3919	38	ED	ED	NNP
cord-006229-7yoilsho	3919	39	activities	activity	NNS
cord-006229-7yoilsho	3919	40	.	.	.
cord-006229-7yoilsho	3920	1	Among	among	IN
cord-006229-7yoilsho	3920	2	them	-PRON-	PRP
cord-006229-7yoilsho	3920	3	,	,	,
cord-006229-7yoilsho	3920	4	3585	3585	CD
cord-006229-7yoilsho	3920	5	chemicals	chemical	NNS
cord-006229-7yoilsho	3920	6	(	(	-LRB-
cord-006229-7yoilsho	3920	7	ca	ca	NN
cord-006229-7yoilsho	3920	8	.	.	.
cord-006229-7yoilsho	3920	9	11	11	CD
cord-006229-7yoilsho	3920	10	%	%	NN
cord-006229-7yoilsho	3920	11	)	)	-RRB-
cord-006229-7yoilsho	3920	12	are	be	VBP
cord-006229-7yoilsho	3920	13	indicated	indicate	VBN
cord-006229-7yoilsho	3920	14	as	as	IN
cord-006229-7yoilsho	3920	15	potential	potential	JJ
cord-006229-7yoilsho	3920	16	candidates	candidate	NNS
cord-006229-7yoilsho	3920	17	for	for	IN
cord-006229-7yoilsho	3920	18	endocrine	endocrine	JJ
cord-006229-7yoilsho	3920	19	effects	effect	NNS
cord-006229-7yoilsho	3920	20	based	base	VBN
cord-006229-7yoilsho	3920	21	on	on	IN
cord-006229-7yoilsho	3920	22	structural	structural	JJ
cord-006229-7yoilsho	3920	23	alerts	alert	NNS
cord-006229-7yoilsho	3920	24	.	.	.
cord-006229-7yoilsho	3921	1	Due	due	IN
cord-006229-7yoilsho	3921	2	to	to	IN
cord-006229-7yoilsho	3921	3	the	the	DT
cord-006229-7yoilsho	3921	4	possibility	possibility	NN
cord-006229-7yoilsho	3921	5	that	that	IN
cord-006229-7yoilsho	3921	6	these	these	DT
cord-006229-7yoilsho	3921	7	chemicals	chemical	NNS
cord-006229-7yoilsho	3921	8	may	may	MD
cord-006229-7yoilsho	3921	9	interact	interact	VB
cord-006229-7yoilsho	3921	10	with	with	IN
cord-006229-7yoilsho	3921	11	estrogen	estrogen	NN
cord-006229-7yoilsho	3921	12	/	/	SYM
cord-006229-7yoilsho	3921	13	androgen	androgen	NN
cord-006229-7yoilsho	3921	14	receptors	receptor	NNS
cord-006229-7yoilsho	3921	15	they	-PRON-	PRP
cord-006229-7yoilsho	3921	16	should	should	MD
cord-006229-7yoilsho	3921	17	be	be	VB
cord-006229-7yoilsho	3921	18	subject	subject	JJ
cord-006229-7yoilsho	3921	19	to	to	IN
cord-006229-7yoilsho	3921	20	further	further	JJ
cord-006229-7yoilsho	3921	21	investigations	investigation	NNS
cord-006229-7yoilsho	3921	22	regarding	regard	VBG
cord-006229-7yoilsho	3921	23	their	-PRON-	PRP$
cord-006229-7yoilsho	3921	24	potential	potential	NN
cord-006229-7yoilsho	3921	25	for	for	IN
cord-006229-7yoilsho	3921	26	endocrine	endocrine	JJ
cord-006229-7yoilsho	3921	27	effects	effect	NNS
cord-006229-7yoilsho	3921	28	,	,	,
cord-006229-7yoilsho	3921	29	eventually	eventually	RB
cord-006229-7yoilsho	3921	30	leading	lead	VBG
cord-006229-7yoilsho	3921	31	to	to	IN
cord-006229-7yoilsho	3921	32	regulatory	regulatory	JJ
cord-006229-7yoilsho	3921	33	actions	action	NNS
cord-006229-7yoilsho	3921	34	.	.	.
cord-006229-7yoilsho	3922	1	Within	within	IN
cord-006229-7yoilsho	3922	2	the	the	DT
cord-006229-7yoilsho	3922	3	IMI	IMI	NNP
cord-006229-7yoilsho	3922	4	(	(	-LRB-
cord-006229-7yoilsho	3922	5	Innovative	Innovative	NNP
cord-006229-7yoilsho	3922	6	Medicine	Medicine	NNP
cord-006229-7yoilsho	3922	7	Initiative	Initiative	NNP
cord-006229-7yoilsho	3922	8	)	)	-RRB-
cord-006229-7yoilsho	3922	9	project	project	NN
cord-006229-7yoilsho	3922	10	"	"	``
cord-006229-7yoilsho	3922	11	Intelligence	intelligence	NN
cord-006229-7yoilsho	3922	12	-	-	HYPH
cord-006229-7yoilsho	3922	13	led	lead	VBN
cord-006229-7yoilsho	3922	14	assessment	assessment	NN
cord-006229-7yoilsho	3922	15	of	of	IN
cord-006229-7yoilsho	3922	16	pharmaceuticals	pharmaceutical	NNS
cord-006229-7yoilsho	3922	17	of	of	IN
cord-006229-7yoilsho	3922	18	the	the	DT
cord-006229-7yoilsho	3922	19	environment	environment	NN
cord-006229-7yoilsho	3922	20	"	"	''
cord-006229-7yoilsho	3922	21	(	(	-LRB-
cord-006229-7yoilsho	3922	22	iPiE;http://i	iPiE;http://i	NNP
cord-006229-7yoilsho	3922	23	-	-	HYPH
cord-006229-7yoilsho	3922	24	pie.org/	pie.org/	NNP
cord-006229-7yoilsho	3922	25	)	)	-RRB-
cord-006229-7yoilsho	3922	26	,	,	,
cord-006229-7yoilsho	3922	27	a	a	DT
cord-006229-7yoilsho	3922	28	more	more	RBR
cord-006229-7yoilsho	3922	29	intelligent	intelligent	JJ
cord-006229-7yoilsho	3922	30	environmental	environmental	JJ
cord-006229-7yoilsho	3922	31	testing	testing	NN
cord-006229-7yoilsho	3922	32	and	and	CC
cord-006229-7yoilsho	3922	33	tools	tool	NNS
cord-006229-7yoilsho	3922	34	for	for	IN
cord-006229-7yoilsho	3922	35	prioritisation	prioritisation	NN
cord-006229-7yoilsho	3922	36	of	of	IN
cord-006229-7yoilsho	3922	37	legacy	legacy	NN
cord-006229-7yoilsho	3922	38	compounds	compound	NNS
cord-006229-7yoilsho	3922	39	shall	shall	MD
cord-006229-7yoilsho	3922	40	be	be	VB
cord-006229-7yoilsho	3922	41	developed	develop	VBN
cord-006229-7yoilsho	3922	42	.	.	.
cord-006229-7yoilsho	3923	1	Regarding	regard	VBG
cord-006229-7yoilsho	3923	2	the	the	DT
cord-006229-7yoilsho	3923	3	evaluation	evaluation	NN
cord-006229-7yoilsho	3923	4	of	of	IN
cord-006229-7yoilsho	3923	5	fish	fish	NN
cord-006229-7yoilsho	3923	6	toxicity	toxicity	NN
cord-006229-7yoilsho	3923	7	,	,	,
cord-006229-7yoilsho	3923	8	screening	screening	NN
cord-006229-7yoilsho	3923	9	approaches	approach	NNS
cord-006229-7yoilsho	3923	10	in	in	IN
cord-006229-7yoilsho	3923	11	fish	fish	NN
cord-006229-7yoilsho	3923	12	embryos	embryo	NNS
cord-006229-7yoilsho	3923	13	are	be	VBP
cord-006229-7yoilsho	3923	14	pursued	pursue	VBN
cord-006229-7yoilsho	3923	15	.	.	.
cord-006229-7yoilsho	3924	1	While	while	IN
cord-006229-7yoilsho	3924	2	the	the	DT
cord-006229-7yoilsho	3924	3	standard	standard	JJ
cord-006229-7yoilsho	3924	4	fish	fish	NN
cord-006229-7yoilsho	3924	5	embryo	embryo	NN
cord-006229-7yoilsho	3924	6	toxicity	toxicity	NN
cord-006229-7yoilsho	3924	7	(	(	-LRB-
cord-006229-7yoilsho	3924	8	FET	FET	NNP
cord-006229-7yoilsho	3924	9	)	)	-RRB-
cord-006229-7yoilsho	3924	10	test	test	NN
cord-006229-7yoilsho	3924	11	is	be	VBZ
cord-006229-7yoilsho	3924	12	restricted	restrict	VBN
cord-006229-7yoilsho	3924	13	to	to	IN
cord-006229-7yoilsho	3924	14	lethal	lethal	JJ
cord-006229-7yoilsho	3924	15	parameters	parameter	NNS
cord-006229-7yoilsho	3924	16	more	more	RBR
cord-006229-7yoilsho	3924	17	relevant	relevant	JJ
cord-006229-7yoilsho	3924	18	as	as	IN
cord-006229-7yoilsho	3924	19	substitutes	substitute	NNS
cord-006229-7yoilsho	3924	20	for	for	IN
cord-006229-7yoilsho	3924	21	acute	acute	JJ
cord-006229-7yoilsho	3924	22	effects	effect	NNS
cord-006229-7yoilsho	3924	23	,	,	,
cord-006229-7yoilsho	3924	24	additional	additional	JJ
cord-006229-7yoilsho	3924	25	sublethal	sublethal	JJ
cord-006229-7yoilsho	3924	26	endpoints	endpoint	NNS
cord-006229-7yoilsho	3924	27	may	may	MD
cord-006229-7yoilsho	3924	28	provide	provide	VB
cord-006229-7yoilsho	3924	29	expanded	expand	VBN
cord-006229-7yoilsho	3924	30	applicability	applicability	NN
cord-006229-7yoilsho	3924	31	of	of	IN
cord-006229-7yoilsho	3924	32	the	the	DT
cord-006229-7yoilsho	3924	33	FET	FET	NNP
cord-006229-7yoilsho	3924	34	assay	assay	NN
cord-006229-7yoilsho	3924	35	for	for	IN
cord-006229-7yoilsho	3924	36	chronic	chronic	JJ
cord-006229-7yoilsho	3924	37	effect	effect	NN
cord-006229-7yoilsho	3924	38	assessment	assessment	NN
cord-006229-7yoilsho	3924	39	in	in	IN
cord-006229-7yoilsho	3924	40	fish	fish	NN
cord-006229-7yoilsho	3924	41	.	.	.
cord-006229-7yoilsho	3925	1	In	in	IN
cord-006229-7yoilsho	3925	2	this	this	DT
cord-006229-7yoilsho	3925	3	respect	respect	NN
cord-006229-7yoilsho	3925	4	,	,	,
cord-006229-7yoilsho	3925	5	the	the	DT
cord-006229-7yoilsho	3925	6	analysis	analysis	NN
cord-006229-7yoilsho	3925	7	of	of	IN
cord-006229-7yoilsho	3925	8	the	the	DT
cord-006229-7yoilsho	3925	9	metabolome	metabolome	NN
cord-006229-7yoilsho	3925	10	could	could	MD
cord-006229-7yoilsho	3925	11	provide	provide	VB
cord-006229-7yoilsho	3925	12	additional	additional	JJ
cord-006229-7yoilsho	3925	13	insights	insight	NNS
cord-006229-7yoilsho	3925	14	into	into	IN
cord-006229-7yoilsho	3925	15	biochemical	biochemical	JJ
cord-006229-7yoilsho	3925	16	processes	process	NNS
cord-006229-7yoilsho	3925	17	elicited	elicit	VBN
cord-006229-7yoilsho	3925	18	by	by	IN
cord-006229-7yoilsho	3925	19	pharmaceutical	pharmaceutical	JJ
cord-006229-7yoilsho	3925	20	compounds	compound	NNS
cord-006229-7yoilsho	3925	21	and	and	CC
cord-006229-7yoilsho	3925	22	could	could	MD
cord-006229-7yoilsho	3925	23	potentially	potentially	RB
cord-006229-7yoilsho	3925	24	support	support	VB
cord-006229-7yoilsho	3925	25	the	the	DT
cord-006229-7yoilsho	3925	26	extrapolation	extrapolation	NN
cord-006229-7yoilsho	3925	27	from	from	IN
cord-006229-7yoilsho	3925	28	fish	fish	NN
cord-006229-7yoilsho	3925	29	embryo	embryo	NN
cord-006229-7yoilsho	3925	30	to	to	IN
cord-006229-7yoilsho	3925	31	chronic	chronic	JJ
cord-006229-7yoilsho	3925	32	fish	fish	NN
cord-006229-7yoilsho	3925	33	toxicity	toxicity	NN
cord-006229-7yoilsho	3925	34	as	as	IN
cord-006229-7yoilsho	3925	35	displayed	display	VBN
cord-006229-7yoilsho	3925	36	in	in	IN
cord-006229-7yoilsho	3925	37	the	the	DT
cord-006229-7yoilsho	3925	38	standard	standard	JJ
cord-006229-7yoilsho	3925	39	early	early	JJ
cord-006229-7yoilsho	3925	40	life	life	NN
cord-006229-7yoilsho	3925	41	stage	stage	NN
cord-006229-7yoilsho	3925	42	(	(	-LRB-
cord-006229-7yoilsho	3925	43	ELS	ELS	NNP
cord-006229-7yoilsho	3925	44	)	)	-RRB-
cord-006229-7yoilsho	3925	45	test	test	NN
cord-006229-7yoilsho	3925	46	.	.	.
cord-006229-7yoilsho	3926	1	In	in	IN
cord-006229-7yoilsho	3926	2	the	the	DT
cord-006229-7yoilsho	3926	3	context	context	NN
cord-006229-7yoilsho	3926	4	of	of	IN
cord-006229-7yoilsho	3926	5	iPiE	iPiE	NNP
cord-006229-7yoilsho	3926	6	a	a	DT
cord-006229-7yoilsho	3926	7	pilot	pilot	NN
cord-006229-7yoilsho	3926	8	study	study	NN
cord-006229-7yoilsho	3926	9	was	be	VBD
cord-006229-7yoilsho	3926	10	performed	perform	VBN
cord-006229-7yoilsho	3926	11	with	with	IN
cord-006229-7yoilsho	3926	12	the	the	DT
cord-006229-7yoilsho	3926	13	aim	aim	NN
cord-006229-7yoilsho	3926	14	to	to	TO
cord-006229-7yoilsho	3926	15	quantify	quantify	VB
cord-006229-7yoilsho	3926	16	and	and	CC
cord-006229-7yoilsho	3926	17	comparatively	comparatively	RB
cord-006229-7yoilsho	3926	18	assess	assess	VB
cord-006229-7yoilsho	3926	19	changes	change	NNS
cord-006229-7yoilsho	3926	20	in	in	IN
cord-006229-7yoilsho	3926	21	the	the	DT
cord-006229-7yoilsho	3926	22	metabolic	metabolic	JJ
cord-006229-7yoilsho	3926	23	signatures	signature	NNS
cord-006229-7yoilsho	3926	24	of	of	IN
cord-006229-7yoilsho	3926	25	fish	fish	NN
cord-006229-7yoilsho	3926	26	and	and	CC
cord-006229-7yoilsho	3926	27	fish	fish	NN
cord-006229-7yoilsho	3926	28	embryos	embryo	NNS
cord-006229-7yoilsho	3926	29	induced	induce	VBN
cord-006229-7yoilsho	3926	30	by	by	IN
cord-006229-7yoilsho	3926	31	the	the	DT
cord-006229-7yoilsho	3926	32	reference	reference	NN
cord-006229-7yoilsho	3926	33	compound	compound	NN
cord-006229-7yoilsho	3926	34	amikacin	amikacin	NNP
cord-006229-7yoilsho	3926	35	,	,	,
cord-006229-7yoilsho	3926	36	an	an	DT
cord-006229-7yoilsho	3926	37	aminoglycoside	aminoglycoside	JJ
cord-006229-7yoilsho	3926	38	antibiotic	antibiotic	NN
cord-006229-7yoilsho	3926	39	,	,	,
cord-006229-7yoilsho	3926	40	in	in	IN
cord-006229-7yoilsho	3926	41	order	order	NN
cord-006229-7yoilsho	3926	42	to	to	TO
cord-006229-7yoilsho	3926	43	identify	identify	VB
cord-006229-7yoilsho	3926	44	metabolic	metabolic	JJ
cord-006229-7yoilsho	3926	45	patterns	pattern	NNS
cord-006229-7yoilsho	3926	46	applicable	applicable	JJ
cord-006229-7yoilsho	3926	47	as	as	IN
cord-006229-7yoilsho	3926	48	biomarker	biomarker	NN
cord-006229-7yoilsho	3926	49	profiles	profile	NNS
cord-006229-7yoilsho	3926	50	that	that	WDT
cord-006229-7yoilsho	3926	51	can	can	MD
cord-006229-7yoilsho	3926	52	be	be	VB
cord-006229-7yoilsho	3926	53	linked	link	VBN
cord-006229-7yoilsho	3926	54	to	to	IN
cord-006229-7yoilsho	3926	55	apical	apical	JJ
cord-006229-7yoilsho	3926	56	endpoints	endpoint	NNS
cord-006229-7yoilsho	3926	57	in	in	IN
cord-006229-7yoilsho	3926	58	terms	term	NNS
cord-006229-7yoilsho	3926	59	of	of	IN
cord-006229-7yoilsho	3926	60	an	an	DT
cord-006229-7yoilsho	3926	61	integrated	integrated	JJ
cord-006229-7yoilsho	3926	62	approach	approach	NN
cord-006229-7yoilsho	3926	63	.	.	.
cord-006229-7yoilsho	3927	1	Therefore	therefore	RB
cord-006229-7yoilsho	3927	2	,	,	,
cord-006229-7yoilsho	3927	3	toxic	toxic	JJ
cord-006229-7yoilsho	3927	4	effects	effect	NNS
cord-006229-7yoilsho	3927	5	in	in	IN
cord-006229-7yoilsho	3927	6	fathead	fathead	NN
cord-006229-7yoilsho	3927	7	minnow	minnow	NN
cord-006229-7yoilsho	3927	8	embryos	embryo	NNS
cord-006229-7yoilsho	3927	9	and	and	CC
cord-006229-7yoilsho	3927	10	ELS	ELS	NNP
cord-006229-7yoilsho	3927	11	fish	fish	NN
cord-006229-7yoilsho	3927	12	were	be	VBD
cord-006229-7yoilsho	3927	13	investigated	investigate	VBN
cord-006229-7yoilsho	3927	14	following	follow	VBG
cord-006229-7yoilsho	3927	15	a	a	DT
cord-006229-7yoilsho	3927	16	4	4	CD
cord-006229-7yoilsho	3927	17	and	and	CC
cord-006229-7yoilsho	3927	18	32	32	CD
cord-006229-7yoilsho	3927	19	days	day	NNS
cord-006229-7yoilsho	3927	20	exposure	exposure	NN
cord-006229-7yoilsho	3927	21	,	,	,
cord-006229-7yoilsho	3927	22	examining	examine	VBG
cord-006229-7yoilsho	3927	23	conventional	conventional	JJ
cord-006229-7yoilsho	3927	24	endpoints	endpoint	NNS
cord-006229-7yoilsho	3927	25	and	and	CC
cord-006229-7yoilsho	3927	26	additionally	additionally	RB
cord-006229-7yoilsho	3927	27	using	use	VBG
cord-006229-7yoilsho	3927	28	a	a	DT
cord-006229-7yoilsho	3927	29	combined	combine	VBN
cord-006229-7yoilsho	3927	30	direct	direct	JJ
cord-006229-7yoilsho	3927	31	injection	injection	NN
cord-006229-7yoilsho	3927	32	and	and	CC
cord-006229-7yoilsho	3927	33	LC	LC	NNP
cord-006229-7yoilsho	3927	34	-	-	HYPH
cord-006229-7yoilsho	3927	35	MS	MS	NNP
cord-006229-7yoilsho	3927	36	/	/	SYM
cord-006229-7yoilsho	3927	37	MS	MS	NNP
cord-006229-7yoilsho	3927	38	assay	assay	NN
cord-006229-7yoilsho	3927	39	for	for	IN
cord-006229-7yoilsho	3927	40	metabolite	metabolite	JJ
cord-006229-7yoilsho	3927	41	identification	identification	NN
cord-006229-7yoilsho	3927	42	and	and	CC
cord-006229-7yoilsho	3927	43	quantification	quantification	NN
cord-006229-7yoilsho	3927	44	.	.	.
cord-006229-7yoilsho	3928	1	Metabolic	metabolic	JJ
cord-006229-7yoilsho	3928	2	endpoints	endpoint	NNS
cord-006229-7yoilsho	3928	3	were	be	VBD
cord-006229-7yoilsho	3928	4	found	find	VBN
cord-006229-7yoilsho	3928	5	to	to	TO
cord-006229-7yoilsho	3928	6	be	be	VB
cord-006229-7yoilsho	3928	7	at	at	IN
cord-006229-7yoilsho	3928	8	least	least	JJS
cord-006229-7yoilsho	3928	9	as	as	RB
cord-006229-7yoilsho	3928	10	sensitive	sensitive	JJ
cord-006229-7yoilsho	3928	11	as	as	IN
cord-006229-7yoilsho	3928	12	standard	standard	JJ
cord-006229-7yoilsho	3928	13	apical	apical	JJ
cord-006229-7yoilsho	3928	14	endpoints	endpoint	NNS
cord-006229-7yoilsho	3928	15	such	such	JJ
cord-006229-7yoilsho	3928	16	as	as	IN
cord-006229-7yoilsho	3928	17	growth	growth	NN
cord-006229-7yoilsho	3928	18	and	and	CC
cord-006229-7yoilsho	3928	19	mortality	mortality	NN
cord-006229-7yoilsho	3928	20	as	as	IN
cord-006229-7yoilsho	3928	21	detected	detect	VBN
cord-006229-7yoilsho	3928	22	in	in	IN
cord-006229-7yoilsho	3928	23	the	the	DT
cord-006229-7yoilsho	3928	24	longer	long	JJR
cord-006229-7yoilsho	3928	25	-	-	HYPH
cord-006229-7yoilsho	3928	26	term	term	NN
cord-006229-7yoilsho	3928	27	fish	fish	NN
cord-006229-7yoilsho	3928	28	study	study	NN
cord-006229-7yoilsho	3928	29	.	.	.
cord-006229-7yoilsho	3929	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	3929	2	,	,	,
cord-006229-7yoilsho	3929	3	multivariate	multivariate	JJ
cord-006229-7yoilsho	3929	4	data	datum	NNS
cord-006229-7yoilsho	3929	5	analysis	analysis	NN
cord-006229-7yoilsho	3929	6	(	(	-LRB-
cord-006229-7yoilsho	3929	7	PCA	PCA	NNP
cord-006229-7yoilsho	3929	8	-	-	HYPH
cord-006229-7yoilsho	3929	9	X	X	NNP
cord-006229-7yoilsho	3929	10	,	,	,
cord-006229-7yoilsho	3929	11	OPLS	OPLS	NNP
cord-006229-7yoilsho	3929	12	-	-	HYPH
cord-006229-7yoilsho	3929	13	DA	DA	NNP
cord-006229-7yoilsho	3929	14	)	)	-RRB-
cord-006229-7yoilsho	3929	15	revealed	reveal	VBD
cord-006229-7yoilsho	3929	16	substance	substance	NN
cord-006229-7yoilsho	3929	17	induced	induce	VBD
cord-006229-7yoilsho	3929	18	metabolic	metabolic	JJ
cord-006229-7yoilsho	3929	19	perturbations	perturbation	NNS
cord-006229-7yoilsho	3929	20	specific	specific	JJ
cord-006229-7yoilsho	3929	21	for	for	IN
cord-006229-7yoilsho	3929	22	fish	fish	NN
cord-006229-7yoilsho	3929	23	and	and	CC
cord-006229-7yoilsho	3929	24	fish	fish	NN
cord-006229-7yoilsho	3929	25	embryos	embryo	NNS
cord-006229-7yoilsho	3929	26	,	,	,
cord-006229-7yoilsho	3929	27	respectively	respectively	RB
cord-006229-7yoilsho	3929	28	.	.	.
cord-006229-7yoilsho	3930	1	Beyond	beyond	IN
cord-006229-7yoilsho	3930	2	that	that	DT
cord-006229-7yoilsho	3930	3	,	,	,
cord-006229-7yoilsho	3930	4	the	the	DT
cord-006229-7yoilsho	3930	5	statistical	statistical	JJ
cord-006229-7yoilsho	3930	6	approach	approach	NN
cord-006229-7yoilsho	3930	7	of	of	IN
cord-006229-7yoilsho	3930	8	shared	share	VBN
cord-006229-7yoilsho	3930	9	and	and	CC
cord-006229-7yoilsho	3930	10	unique	unique	JJ
cord-006229-7yoilsho	3930	11	structure	structure	NN
cord-006229-7yoilsho	3930	12	(	(	-LRB-
cord-006229-7yoilsho	3930	13	SUS	SUS	NNP
cord-006229-7yoilsho	3930	14	)	)	-RRB-
cord-006229-7yoilsho	3930	15	identified	identify	VBD
cord-006229-7yoilsho	3930	16	some	some	DT
cord-006229-7yoilsho	3930	17	metabolites	metabolite	NNS
cord-006229-7yoilsho	3930	18	from	from	IN
cord-006229-7yoilsho	3930	19	the	the	DT
cord-006229-7yoilsho	3930	20	classes	class	NNS
cord-006229-7yoilsho	3930	21	of	of	IN
cord-006229-7yoilsho	3930	22	amino	amino	JJ
cord-006229-7yoilsho	3930	23	acids	acid	NNS
cord-006229-7yoilsho	3930	24	,	,	,
cord-006229-7yoilsho	3930	25	biogenic	biogenic	JJ
cord-006229-7yoilsho	3930	26	amines	amine	NNS
cord-006229-7yoilsho	3930	27	and	and	CC
cord-006229-7yoilsho	3930	28	lipids	lipid	NNS
cord-006229-7yoilsho	3930	29	to	to	TO
cord-006229-7yoilsho	3930	30	be	be	VB
cord-006229-7yoilsho	3930	31	similarly	similarly	RB
cord-006229-7yoilsho	3930	32	changed	change	VBN
cord-006229-7yoilsho	3930	33	in	in	IN
cord-006229-7yoilsho	3930	34	both	both	DT
cord-006229-7yoilsho	3930	35	developmental	developmental	JJ
cord-006229-7yoilsho	3930	36	stages	stage	NNS
cord-006229-7yoilsho	3930	37	related	relate	VBN
cord-006229-7yoilsho	3930	38	to	to	IN
cord-006229-7yoilsho	3930	39	amikacin	amikacin	JJ
cord-006229-7yoilsho	3930	40	treatment	treatment	NN
cord-006229-7yoilsho	3930	41	,	,	,
cord-006229-7yoilsho	3930	42	representing	represent	VBG
cord-006229-7yoilsho	3930	43	shared	share	VBN
cord-006229-7yoilsho	3930	44	biomarker	biomarker	NN
cord-006229-7yoilsho	3930	45	candidates	candidate	NNS
cord-006229-7yoilsho	3930	46	.	.	.
cord-006229-7yoilsho	3931	1	In	in	IN
cord-006229-7yoilsho	3931	2	this	this	DT
cord-006229-7yoilsho	3931	3	first	first	JJ
cord-006229-7yoilsho	3931	4	pilot	pilot	NN
cord-006229-7yoilsho	3931	5	study	study	NN
cord-006229-7yoilsho	3931	6	,	,	,
cord-006229-7yoilsho	3931	7	the	the	DT
cord-006229-7yoilsho	3931	8	integrated	integrated	JJ
cord-006229-7yoilsho	3931	9	metabolomics	metabolomic	NNS
cord-006229-7yoilsho	3931	10	approach	approach	NN
cord-006229-7yoilsho	3931	11	yielded	yield	VBD
cord-006229-7yoilsho	3931	12	insights	insight	NNS
cord-006229-7yoilsho	3931	13	into	into	IN
cord-006229-7yoilsho	3931	14	the	the	DT
cord-006229-7yoilsho	3931	15	molecular	molecular	JJ
cord-006229-7yoilsho	3931	16	consequences	consequence	NNS
cord-006229-7yoilsho	3931	17	of	of	IN
cord-006229-7yoilsho	3931	18	amikacin	amikacin	JJ
cord-006229-7yoilsho	3931	19	exposure	exposure	NN
cord-006229-7yoilsho	3931	20	and	and	CC
cord-006229-7yoilsho	3931	21	provided	provide	VBN
cord-006229-7yoilsho	3931	22	indications	indication	NNS
cord-006229-7yoilsho	3931	23	for	for	IN
cord-006229-7yoilsho	3931	24	biomarkers	biomarker	NNS
cord-006229-7yoilsho	3931	25	for	for	IN
cord-006229-7yoilsho	3931	26	common	common	JJ
cord-006229-7yoilsho	3931	27	effects	effect	NNS
cord-006229-7yoilsho	3931	28	in	in	IN
cord-006229-7yoilsho	3931	29	fish	fish	NN
cord-006229-7yoilsho	3931	30	embryos	embryo	NNS
cord-006229-7yoilsho	3931	31	and	and	CC
cord-006229-7yoilsho	3931	32	fish	fish	NN
cord-006229-7yoilsho	3931	33	.	.	.
cord-006229-7yoilsho	3932	1	Due	due	IN
cord-006229-7yoilsho	3932	2	to	to	IN
cord-006229-7yoilsho	3932	3	the	the	DT
cord-006229-7yoilsho	3932	4	different	different	JJ
cord-006229-7yoilsho	3932	5	exposure	exposure	NN
cord-006229-7yoilsho	3932	6	levels	level	NNS
cord-006229-7yoilsho	3932	7	in	in	IN
cord-006229-7yoilsho	3932	8	the	the	DT
cord-006229-7yoilsho	3932	9	FET	fet	NN
cord-006229-7yoilsho	3932	10	(	(	-LRB-
cord-006229-7yoilsho	3932	11	1	1	CD
cord-006229-7yoilsho	3932	12	-100	-100	NNS
cord-006229-7yoilsho	3932	13	mg	mg	NNP
cord-006229-7yoilsho	3932	14	/	/	SYM
cord-006229-7yoilsho	3932	15	L	L	NNP
cord-006229-7yoilsho	3932	16	)	)	-RRB-
cord-006229-7yoilsho	3932	17	and	and	CC
cord-006229-7yoilsho	3932	18	ELS	ELS	NNP
cord-006229-7yoilsho	3932	19	study	study	NN
cord-006229-7yoilsho	3932	20	(	(	-LRB-
cord-006229-7yoilsho	3932	21	0.0003	0.0003	CD
cord-006229-7yoilsho	3932	22	-0.03	-0.03	CD
cord-006229-7yoilsho	3932	23	mg	mg	NNP
cord-006229-7yoilsho	3932	24	/	/	SYM
cord-006229-7yoilsho	3932	25	L	L	NNP
cord-006229-7yoilsho	3932	26	)	)	-RRB-
cord-006229-7yoilsho	3932	27	,	,	,
cord-006229-7yoilsho	3932	28	more	more	RBR
cord-006229-7yoilsho	3932	29	definitive	definitive	JJ
cord-006229-7yoilsho	3932	30	conclusions	conclusion	NNS
cord-006229-7yoilsho	3932	31	regarding	regard	VBG
cord-006229-7yoilsho	3932	32	the	the	DT
cord-006229-7yoilsho	3932	33	predictivity	predictivity	NN
cord-006229-7yoilsho	3932	34	of	of	IN
cord-006229-7yoilsho	3932	35	metabolic	metabolic	JJ
cord-006229-7yoilsho	3932	36	responses	response	NNS
cord-006229-7yoilsho	3932	37	in	in	IN
cord-006229-7yoilsho	3932	38	fish	fish	NN
cord-006229-7yoilsho	3932	39	embryos	embryo	NNS
cord-006229-7yoilsho	3932	40	for	for	IN
cord-006229-7yoilsho	3932	41	apical	apical	JJ
cord-006229-7yoilsho	3932	42	endpoints	endpoint	NNS
cord-006229-7yoilsho	3932	43	in	in	IN
cord-006229-7yoilsho	3932	44	chronic	chronic	JJ
cord-006229-7yoilsho	3932	45	fish	fish	NN
cord-006229-7yoilsho	3932	46	tests	test	NNS
cord-006229-7yoilsho	3932	47	are	be	VBP
cord-006229-7yoilsho	3932	48	yet	yet	RB
cord-006229-7yoilsho	3932	49	not	not	RB
cord-006229-7yoilsho	3932	50	possible	possible	JJ
cord-006229-7yoilsho	3932	51	.	.	.
cord-006229-7yoilsho	3933	1	Further	further	JJ
cord-006229-7yoilsho	3933	2	studies	study	NNS
cord-006229-7yoilsho	3933	3	are	be	VBP
cord-006229-7yoilsho	3933	4	ongoing	ongoing	JJ
cord-006229-7yoilsho	3933	5	with	with	IN
cord-006229-7yoilsho	3933	6	a	a	DT
cord-006229-7yoilsho	3933	7	range	range	NN
cord-006229-7yoilsho	3933	8	of	of	IN
cord-006229-7yoilsho	3933	9	pharmaceutical	pharmaceutical	JJ
cord-006229-7yoilsho	3933	10	compounds	compound	NNS
cord-006229-7yoilsho	3933	11	of	of	IN
cord-006229-7yoilsho	3933	12	different	different	JJ
cord-006229-7yoilsho	3933	13	chemical	chemical	NN
cord-006229-7yoilsho	3933	14	classes	class	NNS
cord-006229-7yoilsho	3933	15	which	which	WDT
cord-006229-7yoilsho	3933	16	will	will	MD
cord-006229-7yoilsho	3933	17	reveal	reveal	VB
cord-006229-7yoilsho	3933	18	more	more	RBR
cord-006229-7yoilsho	3933	19	substantial	substantial	JJ
cord-006229-7yoilsho	3933	20	information	information	NN
cord-006229-7yoilsho	3933	21	on	on	IN
cord-006229-7yoilsho	3933	22	the	the	DT
cord-006229-7yoilsho	3933	23	applicability	applicability	NN
cord-006229-7yoilsho	3933	24	of	of	IN
cord-006229-7yoilsho	3933	25	this	this	DT
cord-006229-7yoilsho	3933	26	technology	technology	NN
cord-006229-7yoilsho	3933	27	in	in	IN
cord-006229-7yoilsho	3933	28	the	the	DT
cord-006229-7yoilsho	3933	29	prediction	prediction	NN
cord-006229-7yoilsho	3933	30	of	of	IN
cord-006229-7yoilsho	3933	31	longterm	longterm	JJ
cord-006229-7yoilsho	3933	32	effects	effect	NNS
cord-006229-7yoilsho	3933	33	in	in	IN
cord-006229-7yoilsho	3933	34	fish	fish	NN
cord-006229-7yoilsho	3933	35	.	.	.
cord-006229-7yoilsho	3934	1	The	the	DT
cord-006229-7yoilsho	3934	2	human	human	JJ
cord-006229-7yoilsho	3934	3	cationic	cationic	JJ
cord-006229-7yoilsho	3934	4	amino	amino	NN
cord-006229-7yoilsho	3934	5	acid	acid	NN
cord-006229-7yoilsho	3934	6	transporter	transporter	NN
cord-006229-7yoilsho	3934	7	hCAT-1	hcat-1	ADD
cord-006229-7yoilsho	3934	8	(	(	-LRB-
cord-006229-7yoilsho	3934	9	SLC7A1	SLC7A1	NNP
cord-006229-7yoilsho	3934	10	)	)	-RRB-
cord-006229-7yoilsho	3934	11	represents	represent	VBZ
cord-006229-7yoilsho	3934	12	the	the	DT
cord-006229-7yoilsho	3934	13	major	major	JJ
cord-006229-7yoilsho	3934	14	uptake	uptake	NN
cord-006229-7yoilsho	3934	15	route	route	NN
cord-006229-7yoilsho	3934	16	for	for	IN
cord-006229-7yoilsho	3934	17	arginine	arginine	NN
cord-006229-7yoilsho	3934	18	and	and	CC
cord-006229-7yoilsho	3934	19	other	other	JJ
cord-006229-7yoilsho	3934	20	cationic	cationic	JJ
cord-006229-7yoilsho	3934	21	amino	amino	NN
cord-006229-7yoilsho	3934	22	acids	acid	NNS
cord-006229-7yoilsho	3934	23	(	(	-LRB-
cord-006229-7yoilsho	3934	24	such	such	JJ
cord-006229-7yoilsho	3934	25	as	as	IN
cord-006229-7yoilsho	3934	26	the	the	DT
cord-006229-7yoilsho	3934	27	essential	essential	JJ
cord-006229-7yoilsho	3934	28	amino	amino	NN
cord-006229-7yoilsho	3934	29	acid	acid	NN
cord-006229-7yoilsho	3934	30	lysine	lysine	NN
cord-006229-7yoilsho	3934	31	)	)	-RRB-
cord-006229-7yoilsho	3934	32	in	in	IN
cord-006229-7yoilsho	3934	33	most	most	JJS
cord-006229-7yoilsho	3934	34	mammalian	mammalian	JJ
cord-006229-7yoilsho	3934	35	cells	cell	NNS
cord-006229-7yoilsho	3934	36	.	.	.
cord-006229-7yoilsho	3935	1	It	-PRON-	PRP
cord-006229-7yoilsho	3935	2	thus	thus	RB
cord-006229-7yoilsho	3935	3	provides	provide	VBZ
cord-006229-7yoilsho	3935	4	these	these	DT
cord-006229-7yoilsho	3935	5	amino	amino	JJ
cord-006229-7yoilsho	3935	6	acids	acid	NNS
cord-006229-7yoilsho	3935	7	for	for	IN
cord-006229-7yoilsho	3935	8	protein	protein	NN
cord-006229-7yoilsho	3935	9	synthesis	synthesis	NN
cord-006229-7yoilsho	3935	10	as	as	RB
cord-006229-7yoilsho	3935	11	well	well	RB
cord-006229-7yoilsho	3935	12	as	as	IN
cord-006229-7yoilsho	3935	13	for	for	IN
cord-006229-7yoilsho	3935	14	essential	essential	JJ
cord-006229-7yoilsho	3935	15	metabolic	metabolic	JJ
cord-006229-7yoilsho	3935	16	pathways	pathway	NNS
cord-006229-7yoilsho	3935	17	.	.	.
cord-006229-7yoilsho	3936	1	In	in	IN
cord-006229-7yoilsho	3936	2	endothelial	endothelial	JJ
cord-006229-7yoilsho	3936	3	cells	cell	NNS
cord-006229-7yoilsho	3936	4	,	,	,
cord-006229-7yoilsho	3936	5	special	special	JJ
cord-006229-7yoilsho	3936	6	attention	attention	NN
cord-006229-7yoilsho	3936	7	has	have	VBZ
cord-006229-7yoilsho	3936	8	been	be	VBN
cord-006229-7yoilsho	3936	9	given	give	VBN
cord-006229-7yoilsho	3936	10	to	to	IN
cord-006229-7yoilsho	3936	11	the	the	DT
cord-006229-7yoilsho	3936	12	role	role	NN
cord-006229-7yoilsho	3936	13	of	of	IN
cord-006229-7yoilsho	3936	14	hCAT-1	hCAT-1	NNP
cord-006229-7yoilsho	3936	15	for	for	IN
cord-006229-7yoilsho	3936	16	supplying	supply	VBG
cord-006229-7yoilsho	3936	17	arginine	arginine	NN
cord-006229-7yoilsho	3936	18	to	to	IN
cord-006229-7yoilsho	3936	19	nitric	nitric	JJ
cord-006229-7yoilsho	3936	20	oxide	oxide	NN
cord-006229-7yoilsho	3936	21	synthase	synthase	NN
cord-006229-7yoilsho	3936	22	.	.	.
cord-006229-7yoilsho	3937	1	In	in	IN
cord-006229-7yoilsho	3937	2	spite	spite	NN
cord-006229-7yoilsho	3937	3	of	of	IN
cord-006229-7yoilsho	3937	4	its	-PRON-	PRP$
cord-006229-7yoilsho	3937	5	wide	wide	JJ
cord-006229-7yoilsho	3937	6	distribution	distribution	NN
cord-006229-7yoilsho	3937	7	,	,	,
cord-006229-7yoilsho	3937	8	hCAT-1	hcat-1	JJ
cord-006229-7yoilsho	3937	9	expression	expression	NN
cord-006229-7yoilsho	3937	10	is	be	VBZ
cord-006229-7yoilsho	3937	11	highly	highly	RB
cord-006229-7yoilsho	3937	12	regulated	regulate	VBN
cord-006229-7yoilsho	3937	13	both	both	DT
cord-006229-7yoilsho	3937	14	,	,	,
cord-006229-7yoilsho	3937	15	on	on	IN
cord-006229-7yoilsho	3937	16	the	the	DT
cord-006229-7yoilsho	3937	17	transcriptional	transcriptional	JJ
cord-006229-7yoilsho	3937	18	and	and	CC
cord-006229-7yoilsho	3937	19	post	post	JJ
cord-006229-7yoilsho	3937	20	-	-	JJ
cord-006229-7yoilsho	3937	21	transcriptional	transcriptional	JJ
cord-006229-7yoilsho	3937	22	level	level	NN
cord-006229-7yoilsho	3937	23	.	.	.
cord-006229-7yoilsho	3938	1	However	however	RB
cord-006229-7yoilsho	3938	2	,	,	,
cord-006229-7yoilsho	3938	3	the	the	DT
cord-006229-7yoilsho	3938	4	genetic	genetic	JJ
cord-006229-7yoilsho	3938	5	elements	element	NNS
cord-006229-7yoilsho	3938	6	involved	involve	VBN
cord-006229-7yoilsho	3938	7	in	in	IN
cord-006229-7yoilsho	3938	8	transcriptional	transcriptional	JJ
cord-006229-7yoilsho	3938	9	regulation	regulation	NN
cord-006229-7yoilsho	3938	10	a	a	DT
cord-006229-7yoilsho	3938	11	largely	largely	RB
cord-006229-7yoilsho	3938	12	unknown	unknown	JJ
cord-006229-7yoilsho	3938	13	.	.	.
cord-006229-7yoilsho	3939	1	Here	here	RB
cord-006229-7yoilsho	3939	2	we	-PRON-	PRP
cord-006229-7yoilsho	3939	3	studied	study	VBD
cord-006229-7yoilsho	3939	4	the	the	DT
cord-006229-7yoilsho	3939	5	expressional	expressional	JJ
cord-006229-7yoilsho	3939	6	regulation	regulation	NN
cord-006229-7yoilsho	3939	7	of	of	IN
cord-006229-7yoilsho	3939	8	hCAT-1	hcat-1	CD
cord-006229-7yoilsho	3939	9	in	in	IN
cord-006229-7yoilsho	3939	10	human	human	JJ
cord-006229-7yoilsho	3939	11	EA.hy926	ea.hy926	JJ
cord-006229-7yoilsho	3939	12	endothelial	endothelial	JJ
cord-006229-7yoilsho	3939	13	cells	cell	NNS
cord-006229-7yoilsho	3939	14	.	.	.
cord-006229-7yoilsho	3940	1	Starvation	starvation	NN
cord-006229-7yoilsho	3940	2	of	of	IN
cord-006229-7yoilsho	3940	3	these	these	DT
cord-006229-7yoilsho	3940	4	cells	cell	NNS
cord-006229-7yoilsho	3940	5	from	from	IN
cord-006229-7yoilsho	3940	6	cationic	cationic	JJ
cord-006229-7yoilsho	3940	7	amino	amino	NN
cord-006229-7yoilsho	3940	8	acids	acid	NNS
cord-006229-7yoilsho	3940	9	led	lead	VBD
cord-006229-7yoilsho	3940	10	to	to	IN
cord-006229-7yoilsho	3940	11	a	a	DT
cord-006229-7yoilsho	3940	12	pronounced	pronounce	VBN
cord-006229-7yoilsho	3940	13	induction	induction	NN
cord-006229-7yoilsho	3940	14	of	of	IN
cord-006229-7yoilsho	3940	15	both	both	DT
cord-006229-7yoilsho	3940	16	,	,	,
cord-006229-7yoilsho	3940	17	hCAT-1	hCAT-1	NNP
cord-006229-7yoilsho	3940	18	mRNA	mrna	NN
cord-006229-7yoilsho	3940	19	and	and	CC
cord-006229-7yoilsho	3940	20	protein	protein	NN
cord-006229-7yoilsho	3940	21	.	.	.
cord-006229-7yoilsho	3941	1	The	the	DT
cord-006229-7yoilsho	3941	2	mRNA	mRNA	NNP
cord-006229-7yoilsho	3941	3	induction	induction	NN
cord-006229-7yoilsho	3941	4	was	be	VBD
cord-006229-7yoilsho	3941	5	almost	almost	RB
cord-006229-7yoilsho	3941	6	completely	completely	RB
cord-006229-7yoilsho	3941	7	abolished	abolish	VBN
cord-006229-7yoilsho	3941	8	by	by	IN
cord-006229-7yoilsho	3941	9	the	the	DT
cord-006229-7yoilsho	3941	10	transcription	transcription	NN
cord-006229-7yoilsho	3941	11	elongation	elongation	NN
cord-006229-7yoilsho	3941	12	inhibitor	inhibitor	NN
cord-006229-7yoilsho	3941	13	DRB	DRB	NNP
cord-006229-7yoilsho	3941	14	(	(	-LRB-
cord-006229-7yoilsho	3941	15	5,6-Dichloro-1-β	5,6-Dichloro-1-β	NNP
cord-006229-7yoilsho	3941	16	-	-	HYPH
cord-006229-7yoilsho	3941	17	Dribofuranosylbenzimidazole	Dribofuranosylbenzimidazole	NNP
cord-006229-7yoilsho	3941	18	)	)	-RRB-
cord-006229-7yoilsho	3941	19	,	,	,
cord-006229-7yoilsho	3941	20	suggesting	suggest	VBG
cord-006229-7yoilsho	3941	21	the	the	DT
cord-006229-7yoilsho	3941	22	involvement	involvement	NN
cord-006229-7yoilsho	3941	23	of	of	IN
cord-006229-7yoilsho	3941	24	transcriptional	transcriptional	JJ
cord-006229-7yoilsho	3941	25	regulation	regulation	NN
cord-006229-7yoilsho	3941	26	.	.	.
cord-006229-7yoilsho	3942	1	We	-PRON-	PRP
cord-006229-7yoilsho	3942	2	thus	thus	RB
cord-006229-7yoilsho	3942	3	aimed	aim	VBD
cord-006229-7yoilsho	3942	4	at	at	IN
cord-006229-7yoilsho	3942	5	identifying	identify	VBG
cord-006229-7yoilsho	3942	6	the	the	DT
cord-006229-7yoilsho	3942	7	promoter	promoter	NN
cord-006229-7yoilsho	3942	8	elements	element	NNS
cord-006229-7yoilsho	3942	9	in	in	IN
cord-006229-7yoilsho	3942	10	the	the	DT
cord-006229-7yoilsho	3942	11	hCAT-1	hCAT-1	NNP
cord-006229-7yoilsho	3942	12	gene	gene	NN
cord-006229-7yoilsho	3942	13	responsible	responsible	JJ
cord-006229-7yoilsho	3942	14	for	for	IN
cord-006229-7yoilsho	3942	15	this	this	DT
cord-006229-7yoilsho	3942	16	regulation	regulation	NN
cord-006229-7yoilsho	3942	17	.	.	.
cord-006229-7yoilsho	3943	1	To	to	IN
cord-006229-7yoilsho	3943	2	our	-PRON-	PRP$
cord-006229-7yoilsho	3943	3	surprise	surprise	NN
cord-006229-7yoilsho	3943	4	and	and	CC
cord-006229-7yoilsho	3943	5	in	in	IN
cord-006229-7yoilsho	3943	6	contrast	contrast	NN
cord-006229-7yoilsho	3943	7	to	to	IN
cord-006229-7yoilsho	3943	8	data	datum	NNS
cord-006229-7yoilsho	3943	9	published	publish	VBN
cord-006229-7yoilsho	3943	10	by	by	IN
cord-006229-7yoilsho	3943	11	others	other	NNS
cord-006229-7yoilsho	3943	12	1	1	CD
cord-006229-7yoilsho	3943	13	the	the	DT
cord-006229-7yoilsho	3943	14	chromosomal	chromosomal	JJ
cord-006229-7yoilsho	3943	15	region	region	NN
cord-006229-7yoilsho	3943	16	up	up	IN
cord-006229-7yoilsho	3943	17	to	to	IN
cord-006229-7yoilsho	3943	18	5	5	CD
cord-006229-7yoilsho	3943	19	kb	kb	NNP
cord-006229-7yoilsho	3943	20	upstream	upstream	RB
cord-006229-7yoilsho	3943	21	of	of	IN
cord-006229-7yoilsho	3943	22	the	the	DT
cord-006229-7yoilsho	3943	23	first	first	JJ
cord-006229-7yoilsho	3943	24	hCAT-1	hcat-1	CD
cord-006229-7yoilsho	3943	25	exon	exon	NN
cord-006229-7yoilsho	3943	26	exhibited	exhibit	VBD
cord-006229-7yoilsho	3943	27	no	no	DT
cord-006229-7yoilsho	3943	28	promoter	promoter	NN
cord-006229-7yoilsho	3943	29	activity	activity	NN
cord-006229-7yoilsho	3943	30	in	in	IN
cord-006229-7yoilsho	3943	31	either	either	CC
cord-006229-7yoilsho	3943	32	endothelial	endothelial	JJ
cord-006229-7yoilsho	3943	33	or	or	CC
cord-006229-7yoilsho	3943	34	DLD-1	dld-1	JJ
cord-006229-7yoilsho	3943	35	colon	colon	NN
cord-006229-7yoilsho	3943	36	carcinoma	carcinoma	NN
cord-006229-7yoilsho	3943	37	cells	cell	NNS
cord-006229-7yoilsho	3943	38	that	that	WDT
cord-006229-7yoilsho	3943	39	exhibit	exhibit	VBP
cord-006229-7yoilsho	3943	40	a	a	DT
cord-006229-7yoilsho	3943	41	very	very	RB
cord-006229-7yoilsho	3943	42	strong	strong	JJ
cord-006229-7yoilsho	3943	43	endogenous	endogenous	JJ
cord-006229-7yoilsho	3943	44	hCAT-1	hcat-1	CD
cord-006229-7yoilsho	3943	45	expression	expression	NN
cord-006229-7yoilsho	3943	46	.	.	.
cord-006229-7yoilsho	3944	1	We	-PRON-	PRP
cord-006229-7yoilsho	3944	2	could	could	MD
cord-006229-7yoilsho	3944	3	however	however	RB
cord-006229-7yoilsho	3944	4	identify	identify	VB
cord-006229-7yoilsho	3944	5	a	a	DT
cord-006229-7yoilsho	3944	6	promoter	promoter	NN
cord-006229-7yoilsho	3944	7	element	element	NN
cord-006229-7yoilsho	3944	8	within	within	IN
cord-006229-7yoilsho	3944	9	the	the	DT
cord-006229-7yoilsho	3944	10	first	first	JJ
cord-006229-7yoilsho	3944	11	intron	intron	NN
cord-006229-7yoilsho	3944	12	of	of	IN
cord-006229-7yoilsho	3944	13	the	the	DT
cord-006229-7yoilsho	3944	14	hCAT-1	hCAT-1	NNP
cord-006229-7yoilsho	3944	15	gene	gene	NN
cord-006229-7yoilsho	3944	16	.	.	.
cord-006229-7yoilsho	3945	1	Transcriptional	transcriptional	JJ
cord-006229-7yoilsho	3945	2	activity	activity	NN
cord-006229-7yoilsho	3945	3	of	of	IN
cord-006229-7yoilsho	3945	4	this	this	DT
cord-006229-7yoilsho	3945	5	element	element	NN
cord-006229-7yoilsho	3945	6	increased	increase	VBD
cord-006229-7yoilsho	3945	7	upon	upon	IN
cord-006229-7yoilsho	3945	8	amino	amino	NN
cord-006229-7yoilsho	3945	9	acid	acid	NN
cord-006229-7yoilsho	3945	10	starvation	starvation	NN
cord-006229-7yoilsho	3945	11	in	in	IN
cord-006229-7yoilsho	3945	12	a	a	DT
cord-006229-7yoilsho	3945	13	similar	similar	JJ
cord-006229-7yoilsho	3945	14	way	way	NN
cord-006229-7yoilsho	3945	15	as	as	IN
cord-006229-7yoilsho	3945	16	endogenous	endogenous	JJ
cord-006229-7yoilsho	3945	17	hCAT-1	hcat-1	CD
cord-006229-7yoilsho	3945	18	expression	expression	NN
cord-006229-7yoilsho	3945	19	.	.	.
cord-006229-7yoilsho	3946	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	3946	2	results	result	NNS
cord-006229-7yoilsho	3946	3	indicate	indicate	VBP
cord-006229-7yoilsho	3946	4	starvation	starvation	NN
cord-006229-7yoilsho	3946	5	-	-	HYPH
cord-006229-7yoilsho	3946	6	induced	induce	VBN
cord-006229-7yoilsho	3946	7	transcriptional	transcriptional	JJ
cord-006229-7yoilsho	3946	8	regulation	regulation	NN
cord-006229-7yoilsho	3946	9	of	of	IN
cord-006229-7yoilsho	3946	10	hCAT-1	hcat-1	CD
cord-006229-7yoilsho	3946	11	through	through	IN
cord-006229-7yoilsho	3946	12	newly	newly	RB
cord-006229-7yoilsho	3946	13	identified	identify	VBN
cord-006229-7yoilsho	3946	14	promoter	promoter	NN
cord-006229-7yoilsho	3946	15	regions	region	NNS
cord-006229-7yoilsho	3946	16	distinct	distinct	JJ
cord-006229-7yoilsho	3946	17	from	from	IN
cord-006229-7yoilsho	3946	18	those	those	DT
cord-006229-7yoilsho	3946	19	published	publish	VBN
cord-006229-7yoilsho	3946	20	previously	previously	RB
cord-006229-7yoilsho	3946	21	.	.	.
cord-006229-7yoilsho	3947	1	The	the	DT
cord-006229-7yoilsho	3947	2	transport	transport	NN
cord-006229-7yoilsho	3947	3	of	of	IN
cord-006229-7yoilsho	3947	4	a	a	DT
cord-006229-7yoilsho	3947	5	multitude	multitude	NN
cord-006229-7yoilsho	3947	6	of	of	IN
cord-006229-7yoilsho	3947	7	drug	drug	NN
cord-006229-7yoilsho	3947	8	molecules	molecule	NNS
cord-006229-7yoilsho	3947	9	into	into	IN
cord-006229-7yoilsho	3947	10	the	the	DT
cord-006229-7yoilsho	3947	11	cell	cell	NN
cord-006229-7yoilsho	3947	12	is	be	VBZ
cord-006229-7yoilsho	3947	13	mediated	mediate	VBN
cord-006229-7yoilsho	3947	14	by	by	IN
cord-006229-7yoilsho	3947	15	multispecific	multispecific	NNP
cord-006229-7yoilsho	3947	16	organic	organic	NNP
cord-006229-7yoilsho	3947	17	cation	cation	NN
cord-006229-7yoilsho	3947	18	transporters	transporter	NNS
cord-006229-7yoilsho	3947	19	(	(	-LRB-
cord-006229-7yoilsho	3947	20	OCTs	OCTs	NNPS
cord-006229-7yoilsho	3947	21	)	)	-RRB-
cord-006229-7yoilsho	3947	22	,	,	,
cord-006229-7yoilsho	3947	23	belonging	belong	VBG
cord-006229-7yoilsho	3947	24	to	to	IN
cord-006229-7yoilsho	3947	25	the	the	DT
cord-006229-7yoilsho	3947	26	solute	solute	NN
cord-006229-7yoilsho	3947	27	carrier	carrier	NN
cord-006229-7yoilsho	3947	28	group	group	NN
cord-006229-7yoilsho	3947	29	(	(	-LRB-
cord-006229-7yoilsho	3947	30	SLC	SLC	NNP
cord-006229-7yoilsho	3947	31	)	)	-RRB-
cord-006229-7yoilsho	3947	32	.	.	.
cord-006229-7yoilsho	3948	1	One	one	CD
cord-006229-7yoilsho	3948	2	of	of	IN
cord-006229-7yoilsho	3948	3	these	these	DT
cord-006229-7yoilsho	3948	4	families	family	NNS
cord-006229-7yoilsho	3948	5	within	within	IN
cord-006229-7yoilsho	3948	6	this	this	DT
cord-006229-7yoilsho	3948	7	group	group	NN
cord-006229-7yoilsho	3948	8	of	of	IN
cord-006229-7yoilsho	3948	9	membrane	membrane	NN
cord-006229-7yoilsho	3948	10	transport	transport	NN
cord-006229-7yoilsho	3948	11	proteins	protein	NNS
cord-006229-7yoilsho	3948	12	is	be	VBZ
cord-006229-7yoilsho	3948	13	the	the	DT
cord-006229-7yoilsho	3948	14	SLC47-family	SLC47-family	NNP
cord-006229-7yoilsho	3948	15	consisting	consist	VBG
cord-006229-7yoilsho	3948	16	of	of	IN
cord-006229-7yoilsho	3948	17	the	the	DT
cord-006229-7yoilsho	3948	18	two	two	CD
cord-006229-7yoilsho	3948	19	multidrug	multidrug	NN
cord-006229-7yoilsho	3948	20	and	and	CC
cord-006229-7yoilsho	3948	21	toxin	toxin	NN
cord-006229-7yoilsho	3948	22	extrusion	extrusion	NN
cord-006229-7yoilsho	3948	23	transporters	transporter	NNS
cord-006229-7yoilsho	3948	24	MATE-1	MATE-1	NNP
cord-006229-7yoilsho	3948	25	(	(	-LRB-
cord-006229-7yoilsho	3948	26	SLC47A1	SLC47A1	NNP
cord-006229-7yoilsho	3948	27	)	)	-RRB-
cord-006229-7yoilsho	3948	28	and	and	CC
cord-006229-7yoilsho	3948	29	MATE2-K	MATE2-K	NNP
cord-006229-7yoilsho	3948	30	(	(	-LRB-
cord-006229-7yoilsho	3948	31	SLC47A2	slc47a2	NN
cord-006229-7yoilsho	3948	32	)	)	-RRB-
cord-006229-7yoilsho	3948	33	.	.	.
cord-006229-7yoilsho	3949	1	While	while	IN
cord-006229-7yoilsho	3949	2	MATE-1	MATE-1	NNP
cord-006229-7yoilsho	3949	3	is	be	VBZ
cord-006229-7yoilsho	3949	4	highly	highly	RB
cord-006229-7yoilsho	3949	5	expressed	express	VBN
cord-006229-7yoilsho	3949	6	in	in	IN
cord-006229-7yoilsho	3949	7	several	several	JJ
cord-006229-7yoilsho	3949	8	different	different	JJ
cord-006229-7yoilsho	3949	9	tissues	tissue	NNS
cord-006229-7yoilsho	3949	10	like	like	IN
cord-006229-7yoilsho	3949	11	kidney	kidney	NN
cord-006229-7yoilsho	3949	12	,	,	,
cord-006229-7yoilsho	3949	13	liver	liver	NN
cord-006229-7yoilsho	3949	14	,	,	,
cord-006229-7yoilsho	3949	15	skeletal	skeletal	JJ
cord-006229-7yoilsho	3949	16	muscle	muscle	NN
cord-006229-7yoilsho	3949	17	,	,	,
cord-006229-7yoilsho	3949	18	adrenal	adrenal	JJ
cord-006229-7yoilsho	3949	19	glands	gland	NNS
cord-006229-7yoilsho	3949	20	,	,	,
cord-006229-7yoilsho	3949	21	testes	testis	NNS
cord-006229-7yoilsho	3949	22	and	and	CC
cord-006229-7yoilsho	3949	23	heart	heart	NN
cord-006229-7yoilsho	3949	24	,	,	,
cord-006229-7yoilsho	3949	25	MATE2-K	MATE2-K	VBZ
cord-006229-7yoilsho	3949	26	exclusively	exclusively	RB
cord-006229-7yoilsho	3949	27	occurs	occur	VBZ
cord-006229-7yoilsho	3949	28	in	in	IN
cord-006229-7yoilsho	3949	29	the	the	DT
cord-006229-7yoilsho	3949	30	apical	apical	JJ
cord-006229-7yoilsho	3949	31	membrane	membrane	NN
cord-006229-7yoilsho	3949	32	of	of	IN
cord-006229-7yoilsho	3949	33	proximal	proximal	JJ
cord-006229-7yoilsho	3949	34	tubular	tubular	JJ
cord-006229-7yoilsho	3949	35	epithelial	epithelial	JJ
cord-006229-7yoilsho	3949	36	cells	cell	NNS
cord-006229-7yoilsho	3949	37	within	within	IN
cord-006229-7yoilsho	3949	38	the	the	DT
cord-006229-7yoilsho	3949	39	kidney	kidney	NN
cord-006229-7yoilsho	3949	40	.	.	.
cord-006229-7yoilsho	3950	1	Both	both	DT
cord-006229-7yoilsho	3950	2	transport	transport	NN
cord-006229-7yoilsho	3950	3	proteins	protein	NNS
cord-006229-7yoilsho	3950	4	translocate	translocate	VBP
cord-006229-7yoilsho	3950	5	organic	organic	JJ
cord-006229-7yoilsho	3950	6	cations	cation	NNS
cord-006229-7yoilsho	3950	7	in	in	IN
cord-006229-7yoilsho	3950	8	exchange	exchange	NN
cord-006229-7yoilsho	3950	9	of	of	IN
cord-006229-7yoilsho	3950	10	protons	proton	NNS
cord-006229-7yoilsho	3950	11	into	into	IN
cord-006229-7yoilsho	3950	12	as	as	RB
cord-006229-7yoilsho	3950	13	well	well	RB
cord-006229-7yoilsho	3950	14	as	as	IN
cord-006229-7yoilsho	3950	15	out	out	IN
cord-006229-7yoilsho	3950	16	of	of	IN
cord-006229-7yoilsho	3950	17	the	the	DT
cord-006229-7yoilsho	3950	18	cell	cell	NN
cord-006229-7yoilsho	3950	19	.	.	.
cord-006229-7yoilsho	3951	1	To	to	TO
cord-006229-7yoilsho	3951	2	define	define	VB
cord-006229-7yoilsho	3951	3	the	the	DT
cord-006229-7yoilsho	3951	4	affinity	affinity	NN
cord-006229-7yoilsho	3951	5	of	of	IN
cord-006229-7yoilsho	3951	6	both	both	DT
cord-006229-7yoilsho	3951	7	transporters	transporter	NNS
cord-006229-7yoilsho	3951	8	for	for	IN
cord-006229-7yoilsho	3951	9	the	the	DT
cord-006229-7yoilsho	3951	10	anti	anti	JJ
cord-006229-7yoilsho	3951	11	-	-	JJ
cord-006229-7yoilsho	3951	12	diabetic	diabetic	JJ
cord-006229-7yoilsho	3951	13	drug	drug	NN
cord-006229-7yoilsho	3951	14	metformin	metformin	NNP
cord-006229-7yoilsho	3951	15	and	and	CC
cord-006229-7yoilsho	3951	16	to	to	TO
cord-006229-7yoilsho	3951	17	investigate	investigate	VB
cord-006229-7yoilsho	3951	18	their	-PRON-	PRP$
cord-006229-7yoilsho	3951	19	interactions	interaction	NNS
cord-006229-7yoilsho	3951	20	with	with	IN
cord-006229-7yoilsho	3951	21	26	26	CD
cord-006229-7yoilsho	3951	22	different	different	JJ
cord-006229-7yoilsho	3951	23	anti	anti	JJ
cord-006229-7yoilsho	3951	24	-	-	JJ
cord-006229-7yoilsho	3951	25	neoplastic	neoplastic	JJ
cord-006229-7yoilsho	3951	26	agents	agent	NNS
cord-006229-7yoilsho	3951	27	comparative	comparative	JJ
cord-006229-7yoilsho	3951	28	transport	transport	NN
cord-006229-7yoilsho	3951	29	experiments	experiment	NNS
cord-006229-7yoilsho	3951	30	with	with	IN
cord-006229-7yoilsho	3951	31	the	the	DT
cord-006229-7yoilsho	3951	32	model	model	NN
cord-006229-7yoilsho	3951	33	substrate	substrate	NN
cord-006229-7yoilsho	3951	34	1-methyl-4-phenylpyridinium	1-methyl-4-phenylpyridinium	CD
cord-006229-7yoilsho	3952	1	(	(	-LRB-
cord-006229-7yoilsho	3952	2	MPP	MPP	NNP
cord-006229-7yoilsho	3952	3	)	)	-RRB-
cord-006229-7yoilsho	3952	4	have	have	VBP
cord-006229-7yoilsho	3952	5	been	be	VBN
cord-006229-7yoilsho	3952	6	carried	carry	VBN
cord-006229-7yoilsho	3952	7	out	out	RP
cord-006229-7yoilsho	3952	8	.	.	.
cord-006229-7yoilsho	3953	1	Therefore	therefore	RB
cord-006229-7yoilsho	3953	2	stably	stably	RB
cord-006229-7yoilsho	3953	3	transfected	transfecte	VBD
cord-006229-7yoilsho	3953	4	HEK293-cells	hek293-cell	NNS
cord-006229-7yoilsho	3953	5	expressing	express	VBG
cord-006229-7yoilsho	3953	6	MATE-1	MATE-1	NNP
cord-006229-7yoilsho	3953	7	or	or	CC
cord-006229-7yoilsho	3953	8	MATE2-K	MATE2-K	NNP
cord-006229-7yoilsho	3953	9	transport	transport	NN
cord-006229-7yoilsho	3953	10	proteins	protein	NNS
cord-006229-7yoilsho	3953	11	generated	generate	VBN
cord-006229-7yoilsho	3953	12	by	by	IN
cord-006229-7yoilsho	3953	13	PortaCellTec	PortaCellTec	NNP
cord-006229-7yoilsho	3954	1	biosciences	biosciences	NNP
cord-006229-7yoilsho	3954	2	GmbH	GmbH	NNP
cord-006229-7yoilsho	3954	3	and	and	CC
cord-006229-7yoilsho	3954	4	vector	vector	NN
cord-006229-7yoilsho	3954	5	transfected	transfecte	VBN
cord-006229-7yoilsho	3954	6	HEK293-cells	HEK293-cells	NNPS
cord-006229-7yoilsho	3954	7	were	be	VBD
cord-006229-7yoilsho	3954	8	used	use	VBN
cord-006229-7yoilsho	3954	9	.	.	.
cord-006229-7yoilsho	3955	1	The	the	DT
cord-006229-7yoilsho	3955	2	interaction	interaction	NN
cord-006229-7yoilsho	3955	3	analyses	analysis	NNS
cord-006229-7yoilsho	3955	4	were	be	VBD
cord-006229-7yoilsho	3955	5	carried	carry	VBN
cord-006229-7yoilsho	3955	6	out	out	RP
cord-006229-7yoilsho	3955	7	by	by	IN
cord-006229-7yoilsho	3955	8	determining	determine	VBG
cord-006229-7yoilsho	3955	9	the	the	DT
cord-006229-7yoilsho	3955	10	uptake	uptake	NN
cord-006229-7yoilsho	3955	11	of	of	IN
cord-006229-7yoilsho	3955	12	[	[	-LRB-
cord-006229-7yoilsho	3955	13	14	14	CD
cord-006229-7yoilsho	3955	14	C]-metformin	C]-metformin	NNP
cord-006229-7yoilsho	3955	15	and	and	CC
cord-006229-7yoilsho	3955	16	the	the	DT
cord-006229-7yoilsho	3955	17	inhibition	inhibition	NN
cord-006229-7yoilsho	3955	18	of	of	IN
cord-006229-7yoilsho	3955	19	[	[	-LRB-
cord-006229-7yoilsho	3955	20	University	University	NNP
cord-006229-7yoilsho	3955	21	of	of	IN
cord-006229-7yoilsho	3955	22	Basel	Basel	NNP
cord-006229-7yoilsho	3955	23	,	,	,
cord-006229-7yoilsho	3955	24	Basel	Basel	NNP
cord-006229-7yoilsho	3955	25	,	,	,
cord-006229-7yoilsho	3955	26	Switzerland	Switzerland	NNP
cord-006229-7yoilsho	3955	27	Drug	Drug	NNP
cord-006229-7yoilsho	3955	28	transporters	transporter	NNS
cord-006229-7yoilsho	3955	29	play	play	VBP
cord-006229-7yoilsho	3955	30	a	a	DT
cord-006229-7yoilsho	3955	31	pivotal	pivotal	JJ
cord-006229-7yoilsho	3955	32	role	role	NN
cord-006229-7yoilsho	3955	33	in	in	IN
cord-006229-7yoilsho	3955	34	pharmacokinetics	pharmacokinetic	NNS
cord-006229-7yoilsho	3955	35	by	by	IN
cord-006229-7yoilsho	3955	36	modulating	modulate	VBG
cord-006229-7yoilsho	3955	37	the	the	DT
cord-006229-7yoilsho	3955	38	cellular	cellular	JJ
cord-006229-7yoilsho	3955	39	entry	entry	NN
cord-006229-7yoilsho	3955	40	or	or	CC
cord-006229-7yoilsho	3955	41	efflux	efflux	NN
cord-006229-7yoilsho	3955	42	of	of	IN
cord-006229-7yoilsho	3955	43	compounds	compound	NNS
cord-006229-7yoilsho	3955	44	.	.	.
cord-006229-7yoilsho	3956	1	One	one	CD
cord-006229-7yoilsho	3956	2	transporter	transporter	NN
cord-006229-7yoilsho	3956	3	facilitating	facilitate	VBG
cord-006229-7yoilsho	3956	4	the	the	DT
cord-006229-7yoilsho	3956	5	transport	transport	NN
cord-006229-7yoilsho	3956	6	of	of	IN
cord-006229-7yoilsho	3956	7	bile	bile	NN
cord-006229-7yoilsho	3956	8	acids	acid	NNS
cord-006229-7yoilsho	3956	9	,	,	,
cord-006229-7yoilsho	3956	10	steroid	steroid	NN
cord-006229-7yoilsho	3956	11	hormones	hormone	NNS
cord-006229-7yoilsho	3956	12	,	,	,
cord-006229-7yoilsho	3956	13	and	and	CC
cord-006229-7yoilsho	3956	14	statins	statin	NNS
cord-006229-7yoilsho	3956	15	is	be	VBZ
cord-006229-7yoilsho	3956	16	the	the	DT
cord-006229-7yoilsho	3956	17	organic	organic	JJ
cord-006229-7yoilsho	3956	18	anion	anion	NN
cord-006229-7yoilsho	3956	19	transporting	transport	VBG
cord-006229-7yoilsho	3956	20	polypeptide	polypeptide	NN
cord-006229-7yoilsho	3956	21	(	(	-LRB-
cord-006229-7yoilsho	3956	22	OATP	OATP	NNP
cord-006229-7yoilsho	3956	23	)	)	-RRB-
cord-006229-7yoilsho	3956	24	2B1	2b1	CD
cord-006229-7yoilsho	3956	25	that	that	WDT
cord-006229-7yoilsho	3956	26	is	be	VBZ
cord-006229-7yoilsho	3956	27	highly	highly	RB
cord-006229-7yoilsho	3956	28	expressed	express	VBN
cord-006229-7yoilsho	3956	29	in	in	IN
cord-006229-7yoilsho	3956	30	placenta	placenta	NN
cord-006229-7yoilsho	3956	31	,	,	,
cord-006229-7yoilsho	3956	32	liver	liver	NN
cord-006229-7yoilsho	3956	33	,	,	,
cord-006229-7yoilsho	3956	34	and	and	CC
cord-006229-7yoilsho	3956	35	small	small	JJ
cord-006229-7yoilsho	3956	36	intestine	intestine	NN
cord-006229-7yoilsho	3956	37	.	.	.
cord-006229-7yoilsho	3957	1	Especially	especially	RB
cord-006229-7yoilsho	3957	2	its	-PRON-	PRP$
cord-006229-7yoilsho	3957	3	activity	activity	NN
cord-006229-7yoilsho	3957	4	in	in	IN
cord-006229-7yoilsho	3957	5	small	small	JJ
cord-006229-7yoilsho	3957	6	intestine	intestine	NN
cord-006229-7yoilsho	3957	7	and	and	CC
cord-006229-7yoilsho	3957	8	liver	liver	NN
cord-006229-7yoilsho	3957	9	is	be	VBZ
cord-006229-7yoilsho	3957	10	assumed	assume	VBN
cord-006229-7yoilsho	3957	11	to	to	TO
cord-006229-7yoilsho	3957	12	be	be	VB
cord-006229-7yoilsho	3957	13	basis	basis	NN
cord-006229-7yoilsho	3957	14	for	for	IN
cord-006229-7yoilsho	3957	15	specific	specific	JJ
cord-006229-7yoilsho	3957	16	drug	drug	NN
cord-006229-7yoilsho	3957	17	-	-	HYPH
cord-006229-7yoilsho	3957	18	drug	drug	NN
cord-006229-7yoilsho	3957	19	interactions	interaction	NNS
cord-006229-7yoilsho	3957	20	.	.	.
cord-006229-7yoilsho	3958	1	Understanding	understanding	NN
cord-006229-7yoilsho	3958	2	mechanisms	mechanism	NNS
cord-006229-7yoilsho	3958	3	involved	involve	VBN
cord-006229-7yoilsho	3958	4	in	in	IN
cord-006229-7yoilsho	3958	5	pharmacokinetics	pharmacokinetic	NNS
cord-006229-7yoilsho	3958	6	is	be	VBZ
cord-006229-7yoilsho	3958	7	a	a	DT
cord-006229-7yoilsho	3958	8	prerequisite	prerequisite	NN
cord-006229-7yoilsho	3958	9	in	in	IN
cord-006229-7yoilsho	3958	10	drug	drug	NN
cord-006229-7yoilsho	3958	11	development	development	NN
cord-006229-7yoilsho	3958	12	.	.	.
cord-006229-7yoilsho	3959	1	To	to	TO
cord-006229-7yoilsho	3959	2	test	test	VB
cord-006229-7yoilsho	3959	3	whether	whether	IN
cord-006229-7yoilsho	3959	4	there	there	EX
cord-006229-7yoilsho	3959	5	are	be	VBP
cord-006229-7yoilsho	3959	6	species	species	NN
cord-006229-7yoilsho	3959	7	differences	difference	NNS
cord-006229-7yoilsho	3959	8	in	in	IN
cord-006229-7yoilsho	3959	9	transport	transport	NN
cord-006229-7yoilsho	3959	10	activity	activity	NN
cord-006229-7yoilsho	3959	11	we	-PRON-	PRP
cord-006229-7yoilsho	3959	12	compared	compare	VBD
cord-006229-7yoilsho	3959	13	the	the	DT
cord-006229-7yoilsho	3959	14	expression	expression	NN
cord-006229-7yoilsho	3959	15	and	and	CC
cord-006229-7yoilsho	3959	16	function	function	NN
cord-006229-7yoilsho	3959	17	of	of	IN
cord-006229-7yoilsho	3959	18	the	the	DT
cord-006229-7yoilsho	3959	19	human	human	JJ
cord-006229-7yoilsho	3959	20	and	and	CC
cord-006229-7yoilsho	3959	21	rat	rat	NNP
cord-006229-7yoilsho	3959	22	orthologue	orthologue	NNP
cord-006229-7yoilsho	3959	23	.	.	.
cord-006229-7yoilsho	3960	1	First	first	RB
cord-006229-7yoilsho	3960	2	,	,	,
cord-006229-7yoilsho	3960	3	we	-PRON-	PRP
cord-006229-7yoilsho	3960	4	determined	determine	VBD
cord-006229-7yoilsho	3960	5	the	the	DT
cord-006229-7yoilsho	3960	6	transport	transport	NN
cord-006229-7yoilsho	3960	7	activity	activity	NN
cord-006229-7yoilsho	3960	8	of	of	IN
cord-006229-7yoilsho	3960	9	the	the	DT
cord-006229-7yoilsho	3960	10	known	known	JJ
cord-006229-7yoilsho	3960	11	OATP2B1	OATP2B1	NNP
cord-006229-7yoilsho	3960	12	substrate	substrate	NN
cord-006229-7yoilsho	3960	13	estrone	estrone	NN
cord-006229-7yoilsho	3961	1	3sulfate	3sulfate	LS
cord-006229-7yoilsho	3961	2	(	(	-LRB-
cord-006229-7yoilsho	3961	3	E	e	NN
cord-006229-7yoilsho	3961	4	1	1	CD
cord-006229-7yoilsho	3961	5	S	S	NNP
cord-006229-7yoilsho	3961	6	)	)	-RRB-
cord-006229-7yoilsho	3961	7	,	,	,
cord-006229-7yoilsho	3961	8	and	and	CC
cord-006229-7yoilsho	3961	9	observed	observe	VBD
cord-006229-7yoilsho	3961	10	a	a	DT
cord-006229-7yoilsho	3961	11	significantly	significantly	RB
cord-006229-7yoilsho	3961	12	lower	low	JJR
cord-006229-7yoilsho	3961	13	K	K	NNP
cord-006229-7yoilsho	3961	14	m	m	NNP
cord-006229-7yoilsho	3961	15	for	for	IN
cord-006229-7yoilsho	3961	16	MDCK	MDCK	NNP
cord-006229-7yoilsho	3961	17	-	-	HYPH
cord-006229-7yoilsho	3961	18	hOATP2B1	hOATP2B1	NNP
cord-006229-7yoilsho	3961	19	compared	compare	VBN
cord-006229-7yoilsho	3961	20	to	to	IN
cord-006229-7yoilsho	3962	1	.00	.00	NFP
cord-006229-7yoilsho	3962	2	±	±	CD
cord-006229-7yoilsho	3962	3	10.23	10.23	CD
cord-006229-7yoilsho	3962	4	µM	µM	NNP
cord-006229-7yoilsho	3962	5	,	,	,
cord-006229-7yoilsho	3962	6	*	*	NFP
cord-006229-7yoilsho	3962	7	p<0.05	p<0.05	JJ
cord-006229-7yoilsho	3962	8	Student´s	Student´s	NNP
cord-006229-7yoilsho	3962	9	t	t	NN
cord-006229-7yoilsho	3962	10	-	-	HYPH
cord-006229-7yoilsho	3962	11	test	test	NN
cord-006229-7yoilsho	3962	12	)	)	-RRB-
cord-006229-7yoilsho	3962	13	whereas	whereas	IN
cord-006229-7yoilsho	3962	14	there	there	EX
cord-006229-7yoilsho	3962	15	was	be	VBD
cord-006229-7yoilsho	3962	16	no	no	DT
cord-006229-7yoilsho	3962	17	difference	difference	NN
cord-006229-7yoilsho	3962	18	in	in	IN
cord-006229-7yoilsho	3962	19	V	V	NNP
cord-006229-7yoilsho	3962	20	max	max	NN
cord-006229-7yoilsho	3963	1	(	(	-LRB-
cord-006229-7yoilsho	3963	2	MDCK	MDCK	NNP
cord-006229-7yoilsho	3963	3	-	-	HYPH
cord-006229-7yoilsho	3963	4	hOATP2B1	hOATP2B1	NNP
cord-006229-7yoilsho	3963	5	119.4	119.4	CD
cord-006229-7yoilsho	3964	1	±	±	NNP
cord-006229-7yoilsho	3964	2	11.3	11.3	CD
cord-006229-7yoilsho	3964	3	fmol	fmol	NNP
cord-006229-7yoilsho	3964	4	/	/	,
cord-006229-7yoilsho	3964	5	min/µg	min/µg	NNP
cord-006229-7yoilsho	3964	6	protein	protein	NN
cord-006229-7yoilsho	3964	7	;	;	:
cord-006229-7yoilsho	3964	8	MDCK	MDCK	NNP
cord-006229-7yoilsho	3964	9	-	-	HYPH
cord-006229-7yoilsho	3964	10	rOatp2b1	rOatp2b1	NNP
cord-006229-7yoilsho	3965	1	102.3	102.3	CD
cord-006229-7yoilsho	3965	2	±	±	CD
cord-006229-7yoilsho	3965	3	12.8	12.8	CD
cord-006229-7yoilsho	3965	4	fmol	fmol	NNP
cord-006229-7yoilsho	3965	5	/	/	,
cord-006229-7yoilsho	3965	6	min/µg	min/µg	NNP
cord-006229-7yoilsho	3965	7	protein	protein	NN
cord-006229-7yoilsho	3965	8	)	)	-RRB-
cord-006229-7yoilsho	3965	9	.	.	.
cord-006229-7yoilsho	3966	1	The	the	DT
cord-006229-7yoilsho	3966	2	human	human	JJ
cord-006229-7yoilsho	3966	3	OATP2B1	OATP2B1	NNP
cord-006229-7yoilsho	3966	4	exhibits	exhibit	VBZ
cord-006229-7yoilsho	3966	5	multiple	multiple	JJ
cord-006229-7yoilsho	3966	6	binding	bind	VBG
cord-006229-7yoilsho	3966	7	sites	site	NNS
cord-006229-7yoilsho	3966	8	for	for	IN
cord-006229-7yoilsho	3966	9	its	-PRON-	PRP$
cord-006229-7yoilsho	3966	10	substrates	substrate	NNS
cord-006229-7yoilsho	3966	11	that	that	WDT
cord-006229-7yoilsho	3966	12	may	may	MD
cord-006229-7yoilsho	3966	13	explain	explain	VB
cord-006229-7yoilsho	3966	14	specific	specific	JJ
cord-006229-7yoilsho	3966	15	drug	drug	NN
cord-006229-7yoilsho	3966	16	-	-	HYPH
cord-006229-7yoilsho	3966	17	drug	drug	NN
cord-006229-7yoilsho	3966	18	interactions	interaction	NNS
cord-006229-7yoilsho	3966	19	[	[	-LRB-
cord-006229-7yoilsho	3966	20	1	1	CD
cord-006229-7yoilsho	3966	21	]	]	-RRB-
cord-006229-7yoilsho	3966	22	.	.	.
cord-006229-7yoilsho	3967	1	To	to	TO
cord-006229-7yoilsho	3967	2	identify	identify	VB
cord-006229-7yoilsho	3967	3	whether	whether	IN
cord-006229-7yoilsho	3967	4	rat	rat	NN
cord-006229-7yoilsho	3967	5	Oatp2b1	Oatp2b1	NNP
cord-006229-7yoilsho	3967	6	owns	own	VBZ
cord-006229-7yoilsho	3967	7	the	the	DT
cord-006229-7yoilsho	3967	8	same	same	JJ
cord-006229-7yoilsho	3967	9	characteristics	characteristic	NNS
cord-006229-7yoilsho	3967	10	,	,	,
cord-006229-7yoilsho	3967	11	the	the	DT
cord-006229-7yoilsho	3967	12	cellular	cellular	JJ
cord-006229-7yoilsho	3967	13	accumulation	accumulation	NN
cord-006229-7yoilsho	3967	14	of	of	IN
cord-006229-7yoilsho	3967	15	50	50	CD
cord-006229-7yoilsho	3967	16	µM	µm	NN
cord-006229-7yoilsho	3967	17	E	e	NN
cord-006229-7yoilsho	3967	18	1	1	CD
cord-006229-7yoilsho	3967	19	S	s	NN
cord-006229-7yoilsho	3967	20	(	(	-LRB-
cord-006229-7yoilsho	3967	21	low	low	JJ
cord-006229-7yoilsho	3967	22	affinity	affinity	NN
cord-006229-7yoilsho	3967	23	site	site	NN
cord-006229-7yoilsho	3967	24	)	)	-RRB-
cord-006229-7yoilsho	3967	25	or	or	CC
cord-006229-7yoilsho	3967	26	0.005	0.005	NN
cord-006229-7yoilsho	3967	27	µM	µm	NN
cord-006229-7yoilsho	3967	28	E	e	NN
cord-006229-7yoilsho	3967	29	1	1	CD
cord-006229-7yoilsho	3967	30	S	s	NN
cord-006229-7yoilsho	3967	31	(	(	-LRB-
cord-006229-7yoilsho	3967	32	high	high	JJ
cord-006229-7yoilsho	3967	33	affinity	affinity	NN
cord-006229-7yoilsho	3967	34	site	site	NN
cord-006229-7yoilsho	3967	35	)	)	-RRB-
cord-006229-7yoilsho	3967	36	was	be	VBD
cord-006229-7yoilsho	3967	37	determined	determine	VBN
cord-006229-7yoilsho	3967	38	in	in	IN
cord-006229-7yoilsho	3967	39	presence	presence	NN
cord-006229-7yoilsho	3967	40	of	of	IN
cord-006229-7yoilsho	3967	41	specific	specific	JJ
cord-006229-7yoilsho	3967	42	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	3967	43	/	/	SYM
cord-006229-7yoilsho	3967	44	substrates	substrate	NNS
cord-006229-7yoilsho	3967	45	of	of	IN
cord-006229-7yoilsho	3967	46	OATP2B1	OATP2B1	NNP
cord-006229-7yoilsho	3967	47	.	.	.
cord-006229-7yoilsho	3968	1	As	as	IN
cord-006229-7yoilsho	3968	2	observed	observe	VBN
cord-006229-7yoilsho	3968	3	for	for	IN
cord-006229-7yoilsho	3968	4	atorvastatin	atorvastatin	NNP
cord-006229-7yoilsho	3968	5	,	,	,
cord-006229-7yoilsho	3968	6	a	a	DT
cord-006229-7yoilsho	3968	7	known	know	VBN
cord-006229-7yoilsho	3968	8	inhibitor	inhibitor	NN
cord-006229-7yoilsho	3968	9	of	of	IN
cord-006229-7yoilsho	3968	10	both	both	CC
cord-006229-7yoilsho	3968	11	affinity	affinity	NN
cord-006229-7yoilsho	3968	12	sites	site	NNS
cord-006229-7yoilsho	3968	13	,	,	,
cord-006229-7yoilsho	3968	14	the	the	DT
cord-006229-7yoilsho	3968	15	rat	rat	NN
cord-006229-7yoilsho	3968	16	transporter	transporter	NN
cord-006229-7yoilsho	3968	17	failed	fail	VBD
cord-006229-7yoilsho	3968	18	to	to	TO
cord-006229-7yoilsho	3968	19	exhibit	exhibit	VB
cord-006229-7yoilsho	3968	20	the	the	DT
cord-006229-7yoilsho	3968	21	low	low	JJ
cord-006229-7yoilsho	3968	22	affinity	affinity	NN
cord-006229-7yoilsho	3968	23	site	site	NN
cord-006229-7yoilsho	3968	24	.	.	.
cord-006229-7yoilsho	3969	1	In	in	IN
cord-006229-7yoilsho	3969	2	detail	detail	NN
cord-006229-7yoilsho	3969	3	,	,	,
cord-006229-7yoilsho	3969	4	while	while	IN
cord-006229-7yoilsho	3969	5	atorvastatin	atorvastatin	NNP
cord-006229-7yoilsho	3969	6	reduced	reduce	VBD
cord-006229-7yoilsho	3969	7	the	the	DT
cord-006229-7yoilsho	3969	8	accumulation	accumulation	NN
cord-006229-7yoilsho	3969	9	of	of	IN
cord-006229-7yoilsho	3969	10	E	E	NNP
cord-006229-7yoilsho	3969	11	1	1	CD
cord-006229-7yoilsho	3969	12	S	S	NNP
cord-006229-7yoilsho	3969	13	in	in	IN
cord-006229-7yoilsho	3969	14	MDCK	MDCK	NNP
cord-006229-7yoilsho	3969	15	-	-	HYPH
cord-006229-7yoilsho	3969	16	hOATP2B1	hOATP2B1	NNP
cord-006229-7yoilsho	3969	17	cells	cell	NNS
cord-006229-7yoilsho	3969	18	(	(	-LRB-
cord-006229-7yoilsho	3969	19	110.0	110.0	CD
cord-006229-7yoilsho	3969	20	±	±	CD
cord-006229-7yoilsho	3969	21	14.6	14.6	CD
cord-006229-7yoilsho	3969	22	fmol/	fmol/	.
cord-006229-7yoilsho	3970	1	min/µg	min/µg	UH
cord-006229-7yoilsho	3970	2	protein	protein	NN
cord-006229-7yoilsho	3970	3	vs.	vs.	IN
cord-006229-7yoilsho	3971	1	60.7	60.7	CD
cord-006229-7yoilsho	3971	2	±	±	NNP
cord-006229-7yoilsho	3971	3	7.5	7.5	CD
cord-006229-7yoilsho	3971	4	fmol	fmol	NNS
cord-006229-7yoilsho	3971	5	/	/	,
cord-006229-7yoilsho	3971	6	min/µg	min/µg	NNP
cord-006229-7yoilsho	3971	7	protein	protein	NN
cord-006229-7yoilsho	3971	8	,	,	.
cord-006229-7yoilsho	3972	1	*	*	NFP
cord-006229-7yoilsho	3972	2	p<0.05	p<0.05	JJ
cord-006229-7yoilsho	3972	3	Student´s	Student´s	NNP
cord-006229-7yoilsho	3972	4	t	t	NN
cord-006229-7yoilsho	3972	5	-	-	HYPH
cord-006229-7yoilsho	3972	6	test	test	NN
cord-006229-7yoilsho	3972	7	)	)	-RRB-
cord-006229-7yoilsho	3972	8	,	,	,
cord-006229-7yoilsho	3972	9	there	there	EX
cord-006229-7yoilsho	3972	10	was	be	VBD
cord-006229-7yoilsho	3972	11	no	no	DT
cord-006229-7yoilsho	3972	12	inhibition	inhibition	NN
cord-006229-7yoilsho	3972	13	of	of	IN
cord-006229-7yoilsho	3972	14	E	e	NN
cord-006229-7yoilsho	3972	15	1	1	CD
cord-006229-7yoilsho	3972	16	S	s	NN
cord-006229-7yoilsho	3972	17	accumulation	accumulation	NN
cord-006229-7yoilsho	3972	18	in	in	IN
cord-006229-7yoilsho	3972	19	MDCK	MDCK	NNP
cord-006229-7yoilsho	3972	20	-	-	HYPH
cord-006229-7yoilsho	3972	21	rOatp2b1	rOatp2b1	NNP
cord-006229-7yoilsho	3972	22	cells	cell	NNS
cord-006229-7yoilsho	3972	23	(	(	-LRB-
cord-006229-7yoilsho	3972	24	53.2	53.2	CD
cord-006229-7yoilsho	3972	25	±	±	NNP
cord-006229-7yoilsho	3972	26	13.2	13.2	CD
cord-006229-7yoilsho	3972	27	fmol	fmol	NNP
cord-006229-7yoilsho	3972	28	/	/	,
cord-006229-7yoilsho	3972	29	min/µg	min/µg	NNP
cord-006229-7yoilsho	3972	30	protein	protein	NN
cord-006229-7yoilsho	3972	31	vs.	vs.	IN
cord-006229-7yoilsho	3972	32	49.0	49.0	CD
cord-006229-7yoilsho	3972	33	±	±	CD
cord-006229-7yoilsho	3972	34	17.4	17.4	CD
cord-006229-7yoilsho	3972	35	fmol	fmol	NNP
cord-006229-7yoilsho	3972	36	/	/	,
cord-006229-7yoilsho	3972	37	min/µg	min/µg	NNP
cord-006229-7yoilsho	3972	38	protein	protein	NN
cord-006229-7yoilsho	3972	39	)	)	-RRB-
cord-006229-7yoilsho	3972	40	.	.	.
cord-006229-7yoilsho	3973	1	Additionally	additionally	RB
cord-006229-7yoilsho	3973	2	,	,	,
cord-006229-7yoilsho	3973	3	we	-PRON-	PRP
cord-006229-7yoilsho	3973	4	observed	observe	VBD
cord-006229-7yoilsho	3973	5	a	a	DT
cord-006229-7yoilsho	3973	6	different	different	JJ
cord-006229-7yoilsho	3973	7	membrane	membrane	NN
cord-006229-7yoilsho	3973	8	localization	localization	NN
cord-006229-7yoilsho	3973	9	of	of	IN
cord-006229-7yoilsho	3973	10	both	both	DT
cord-006229-7yoilsho	3973	11	transporters	transporter	NNS
cord-006229-7yoilsho	3973	12	as	as	IN
cord-006229-7yoilsho	3973	13	assessed	assess	VBN
cord-006229-7yoilsho	3973	14	by	by	IN
cord-006229-7yoilsho	3973	15	immunofluorescent	immunofluorescent	NN
cord-006229-7yoilsho	3973	16	staining	staining	NN
cord-006229-7yoilsho	3973	17	showing	show	VBG
cord-006229-7yoilsho	3973	18	an	an	DT
cord-006229-7yoilsho	3973	19	apical	apical	JJ
cord-006229-7yoilsho	3973	20	localization	localization	NN
cord-006229-7yoilsho	3973	21	for	for	IN
cord-006229-7yoilsho	3973	22	rat	rat	NN
cord-006229-7yoilsho	3973	23	Oatp2b1	Oatp2b1	NNP
cord-006229-7yoilsho	3973	24	while	while	IN
cord-006229-7yoilsho	3973	25	human	human	JJ
cord-006229-7yoilsho	3973	26	OATP2B1	OATP2B1	NNP
cord-006229-7yoilsho	3973	27	is	be	VBZ
cord-006229-7yoilsho	3973	28	localized	localize	VBN
cord-006229-7yoilsho	3973	29	at	at	IN
cord-006229-7yoilsho	3973	30	the	the	DT
cord-006229-7yoilsho	3973	31	basolateral	basolateral	JJ
cord-006229-7yoilsho	3973	32	pole	pole	NN
cord-006229-7yoilsho	3973	33	of	of	IN
cord-006229-7yoilsho	3973	34	the	the	DT
cord-006229-7yoilsho	3973	35	cellular	cellular	JJ
cord-006229-7yoilsho	3973	36	model	model	NN
cord-006229-7yoilsho	3973	37	.	.	.
cord-006229-7yoilsho	3974	1	Absolute	absolute	JJ
cord-006229-7yoilsho	3974	2	quantification	quantification	NN
cord-006229-7yoilsho	3974	3	of	of	IN
cord-006229-7yoilsho	3974	4	mRNA	mRNA	NNP
cord-006229-7yoilsho	3975	1	(	(	-LRB-
cord-006229-7yoilsho	3975	2	copy	copy	NN
cord-006229-7yoilsho	3975	3	number	number	NN
cord-006229-7yoilsho	3975	4	per	per	IN
cord-006229-7yoilsho	3975	5	1000	1000	CD
cord-006229-7yoilsho	3975	6	ng	ng	NN
cord-006229-7yoilsho	3975	7	of	of	IN
cord-006229-7yoilsho	3975	8	total	total	NNP
cord-006229-7yoilsho	3975	9	RNA	RNA	NNP
cord-006229-7yoilsho	3975	10	)	)	-RRB-
cord-006229-7yoilsho	3975	11	in	in	IN
cord-006229-7yoilsho	3975	12	different	different	JJ
cord-006229-7yoilsho	3975	13	tissues	tissue	NNS
cord-006229-7yoilsho	3975	14	of	of	IN
cord-006229-7yoilsho	3975	15	rat	rat	NN
cord-006229-7yoilsho	3975	16	revealed	reveal	VBD
cord-006229-7yoilsho	3975	17	a	a	DT
cord-006229-7yoilsho	3975	18	high	high	JJ
cord-006229-7yoilsho	3975	19	expression	expression	NN
cord-006229-7yoilsho	3975	20	of	of	IN
cord-006229-7yoilsho	3975	21	Oatp2b1	Oatp2b1	NNP
cord-006229-7yoilsho	3975	22	in	in	IN
cord-006229-7yoilsho	3975	23	liver	liver	NN
cord-006229-7yoilsho	3975	24	(	(	-LRB-
cord-006229-7yoilsho	3975	25	159.6	159.6	CD
cord-006229-7yoilsho	3975	26	±	±	CD
cord-006229-7yoilsho	3975	27	45.5	45.5	CD
cord-006229-7yoilsho	3975	28	)	)	-RRB-
cord-006229-7yoilsho	3975	29	,	,	,
cord-006229-7yoilsho	3975	30	a	a	DT
cord-006229-7yoilsho	3975	31	moderate	moderate	JJ
cord-006229-7yoilsho	3975	32	expression	expression	NN
cord-006229-7yoilsho	3975	33	in	in	IN
cord-006229-7yoilsho	3975	34	small	small	JJ
cord-006229-7yoilsho	3975	35	intestine	intestine	NN
cord-006229-7yoilsho	3975	36	(	(	-LRB-
cord-006229-7yoilsho	3975	37	14.9	14.9	CD
cord-006229-7yoilsho	3975	38	±	±	NNP
cord-006229-7yoilsho	3975	39	4.0	4.0	CD
cord-006229-7yoilsho	3975	40	)	)	-RRB-
cord-006229-7yoilsho	3975	41	and	and	CC
cord-006229-7yoilsho	3975	42	colon	colon	NN
cord-006229-7yoilsho	3975	43	(	(	-LRB-
cord-006229-7yoilsho	3975	44	57.0	57.0	CD
cord-006229-7yoilsho	3975	45	±	±	CD
cord-006229-7yoilsho	3975	46	12.3	12.3	CD
cord-006229-7yoilsho	3975	47	)	)	-RRB-
cord-006229-7yoilsho	3975	48	,	,	,
cord-006229-7yoilsho	3975	49	and	and	CC
cord-006229-7yoilsho	3975	50	a	a	DT
cord-006229-7yoilsho	3975	51	low	low	JJ
cord-006229-7yoilsho	3975	52	expression	expression	NN
cord-006229-7yoilsho	3975	53	level	level	NN
cord-006229-7yoilsho	3975	54	in	in	IN
cord-006229-7yoilsho	3975	55	kidney	kidney	NN
cord-006229-7yoilsho	3975	56	(	(	-LRB-
cord-006229-7yoilsho	3975	57	2.3	2.3	CD
cord-006229-7yoilsho	3975	58	±	±	CD
cord-006229-7yoilsho	3975	59	0.8	0.8	CD
cord-006229-7yoilsho	3975	60	)	)	-RRB-
cord-006229-7yoilsho	3975	61	.	.	.
cord-006229-7yoilsho	3976	1	The	the	DT
cord-006229-7yoilsho	3976	2	latter	latter	JJ
cord-006229-7yoilsho	3976	3	is	be	VBZ
cord-006229-7yoilsho	3976	4	in	in	IN
cord-006229-7yoilsho	3976	5	accordance	accordance	NN
cord-006229-7yoilsho	3976	6	with	with	IN
cord-006229-7yoilsho	3976	7	previous	previous	JJ
cord-006229-7yoilsho	3976	8	findings	finding	NNS
cord-006229-7yoilsho	3976	9	showing	show	VBG
cord-006229-7yoilsho	3976	10	that	that	IN
cord-006229-7yoilsho	3976	11	Oatp2b1	Oatp2b1	NNP
cord-006229-7yoilsho	3976	12	is	be	VBZ
cord-006229-7yoilsho	3976	13	abundant	abundant	JJ
cord-006229-7yoilsho	3976	14	in	in	IN
cord-006229-7yoilsho	3976	15	rat	rat	NN
cord-006229-7yoilsho	3976	16	kidney	kidney	NN
cord-006229-7yoilsho	3976	17	as	as	IN
cord-006229-7yoilsho	3976	18	quantified	quantify	VBN
cord-006229-7yoilsho	3976	19	by	by	IN
cord-006229-7yoilsho	3976	20	absolute	absolute	JJ
cord-006229-7yoilsho	3976	21	proteomics	proteomic	NNS
cord-006229-7yoilsho	3976	22	technics	technic	NNS
cord-006229-7yoilsho	3976	23	[	[	-LRB-
cord-006229-7yoilsho	3976	24	2	2	CD
cord-006229-7yoilsho	3976	25	]	]	-RRB-
cord-006229-7yoilsho	3976	26	.	.	.
cord-006229-7yoilsho	3977	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	3977	2	data	datum	NNS
cord-006229-7yoilsho	3977	3	demonstrated	demonstrate	VBD
cord-006229-7yoilsho	3977	4	species	species	NN
cord-006229-7yoilsho	3977	5	differences	difference	NNS
cord-006229-7yoilsho	3977	6	in	in	IN
cord-006229-7yoilsho	3977	7	localization	localization	NN
cord-006229-7yoilsho	3977	8	and	and	CC
cord-006229-7yoilsho	3977	9	activity	activity	NN
cord-006229-7yoilsho	3977	10	of	of	IN
cord-006229-7yoilsho	3977	11	the	the	DT
cord-006229-7yoilsho	3977	12	drug	drug	NN
cord-006229-7yoilsho	3977	13	transporter	transporter	NN
cord-006229-7yoilsho	3977	14	.	.	.
cord-006229-7yoilsho	3978	1	Further	further	JJ
cord-006229-7yoilsho	3978	2	studies	study	NNS
cord-006229-7yoilsho	3978	3	are	be	VBP
cord-006229-7yoilsho	3978	4	warranted	warrant	VBN
cord-006229-7yoilsho	3978	5	to	to	IN
cord-006229-7yoilsho	3978	6	proof	proof	NN
cord-006229-7yoilsho	3978	7	whether	whether	IN
cord-006229-7yoilsho	3978	8	this	this	DT
cord-006229-7yoilsho	3978	9	knowledge	knowledge	NN
cord-006229-7yoilsho	3978	10	will	will	MD
cord-006229-7yoilsho	3978	11	help	help	VB
cord-006229-7yoilsho	3978	12	in	in	IN
cord-006229-7yoilsho	3978	13	future	future	JJ
cord-006229-7yoilsho	3978	14	drug	drug	NN
cord-006229-7yoilsho	3978	15	development	development	NN
cord-006229-7yoilsho	3978	16	and	and	CC
cord-006229-7yoilsho	3978	17	which	which	WDT
cord-006229-7yoilsho	3978	18	molecular	molecular	JJ
cord-006229-7yoilsho	3978	19	cause	cause	NN
cord-006229-7yoilsho	3978	20	is	be	VBZ
cord-006229-7yoilsho	3978	21	responsible	responsible	JJ
cord-006229-7yoilsho	3978	22	for	for	IN
cord-006229-7yoilsho	3978	23	the	the	DT
cord-006229-7yoilsho	3978	24	observed	observed	JJ
cord-006229-7yoilsho	3978	25	data	datum	NNS
cord-006229-7yoilsho	3978	26	.	.	.
cord-006229-7yoilsho	3979	1	Background	background	NN
cord-006229-7yoilsho	3979	2	:	:	:
cord-006229-7yoilsho	3980	1	Intestinal	intestinal	JJ
cord-006229-7yoilsho	3980	2	drug	drug	NN
cord-006229-7yoilsho	3980	3	absorption	absorption	NN
cord-006229-7yoilsho	3980	4	depends	depend	VBZ
cord-006229-7yoilsho	3980	5	on	on	IN
cord-006229-7yoilsho	3980	6	various	various	JJ
cord-006229-7yoilsho	3980	7	factors	factor	NNS
cord-006229-7yoilsho	3980	8	including	include	VBG
cord-006229-7yoilsho	3980	9	aqueous	aqueous	JJ
cord-006229-7yoilsho	3980	10	volume	volume	NN
cord-006229-7yoilsho	3980	11	,	,	,
cord-006229-7yoilsho	3980	12	site	site	NN
cord-006229-7yoilsho	3980	13	-	-	HYPH
cord-006229-7yoilsho	3980	14	specific	specific	JJ
cord-006229-7yoilsho	3980	15	pH	ph	NN
cord-006229-7yoilsho	3980	16	and	and	CC
cord-006229-7yoilsho	3980	17	intestinal	intestinal	JJ
cord-006229-7yoilsho	3980	18	motility	motility	NN
cord-006229-7yoilsho	3980	19	.	.	.
cord-006229-7yoilsho	3981	1	Moreover	moreover	RB
cord-006229-7yoilsho	3981	2	,	,	,
cord-006229-7yoilsho	3981	3	the	the	DT
cord-006229-7yoilsho	3981	4	expression	expression	NN
cord-006229-7yoilsho	3981	5	of	of	IN
cord-006229-7yoilsho	3981	6	efflux	efflux	NN
cord-006229-7yoilsho	3981	7	-	-	HYPH
cord-006229-7yoilsho	3981	8	and	and	CC
cord-006229-7yoilsho	3981	9	uptake	uptake	NN
cord-006229-7yoilsho	3981	10	-	-	HYPH
cord-006229-7yoilsho	3981	11	transporters	transporter	NNS
cord-006229-7yoilsho	3981	12	vary	vary	VBP
cord-006229-7yoilsho	3981	13	in	in	IN
cord-006229-7yoilsho	3981	14	dependence	dependence	NN
cord-006229-7yoilsho	3981	15	of	of	IN
cord-006229-7yoilsho	3981	16	the	the	DT
cord-006229-7yoilsho	3981	17	anatomical	anatomical	JJ
cord-006229-7yoilsho	3981	18	localization	localization	NN
cord-006229-7yoilsho	3981	19	making	make	VBG
cord-006229-7yoilsho	3981	20	the	the	DT
cord-006229-7yoilsho	3981	21	gut	gut	NN
cord-006229-7yoilsho	3981	22	a	a	DT
cord-006229-7yoilsho	3981	23	complex	complex	JJ
cord-006229-7yoilsho	3981	24	barrier	barrier	NN
cord-006229-7yoilsho	3981	25	for	for	IN
cord-006229-7yoilsho	3981	26	drug	drug	NN
cord-006229-7yoilsho	3981	27	transfer	transfer	NN
cord-006229-7yoilsho	3981	28	into	into	IN
cord-006229-7yoilsho	3981	29	the	the	DT
cord-006229-7yoilsho	3981	30	body	body	NN
cord-006229-7yoilsho	3981	31	.	.	.
cord-006229-7yoilsho	3982	1	In	in	IN
cord-006229-7yoilsho	3982	2	a	a	DT
cord-006229-7yoilsho	3982	3	recent	recent	JJ
cord-006229-7yoilsho	3982	4	study	study	NN
cord-006229-7yoilsho	3982	5	,	,	,
cord-006229-7yoilsho	3982	6	site	site	NN
cord-006229-7yoilsho	3982	7	-	-	HYPH
cord-006229-7yoilsho	3982	8	specific	specific	JJ
cord-006229-7yoilsho	3982	9	protein	protein	NN
cord-006229-7yoilsho	3982	10	and	and	CC
cord-006229-7yoilsho	3982	11	mRNA	mrna	NN
cord-006229-7yoilsho	3982	12	expression	expression	NN
cord-006229-7yoilsho	3982	13	levels	level	NNS
cord-006229-7yoilsho	3982	14	of	of	IN
cord-006229-7yoilsho	3982	15	10	10	CD
cord-006229-7yoilsho	3982	16	drug	drug	NN
cord-006229-7yoilsho	3982	17	transporters	transporter	NNS
cord-006229-7yoilsho	3982	18	were	be	VBD
cord-006229-7yoilsho	3982	19	determined	determine	VBN
cord-006229-7yoilsho	3982	20	along	along	IN
cord-006229-7yoilsho	3982	21	the	the	DT
cord-006229-7yoilsho	3982	22	entire	entire	JJ
cord-006229-7yoilsho	3982	23	length	length	NN
cord-006229-7yoilsho	3982	24	of	of	IN
cord-006229-7yoilsho	3982	25	the	the	DT
cord-006229-7yoilsho	3982	26	human	human	JJ
cord-006229-7yoilsho	3982	27	gut	gut	NN
cord-006229-7yoilsho	3982	28	.	.	.
cord-006229-7yoilsho	3983	1	Interestingly	interestingly	RB
cord-006229-7yoilsho	3983	2	,	,	,
cord-006229-7yoilsho	3983	3	discrepancies	discrepancy	NNS
cord-006229-7yoilsho	3983	4	between	between	IN
cord-006229-7yoilsho	3983	5	mRNA	mRNA	NNP
cord-006229-7yoilsho	3983	6	expression	expression	NN
cord-006229-7yoilsho	3983	7	and	and	CC
cord-006229-7yoilsho	3983	8	protein	protein	NN
cord-006229-7yoilsho	3983	9	levels	level	NNS
cord-006229-7yoilsho	3983	10	were	be	VBD
cord-006229-7yoilsho	3983	11	observed	observe	VBN
cord-006229-7yoilsho	3983	12	.	.	.
cord-006229-7yoilsho	3984	1	Moreover	moreover	RB
cord-006229-7yoilsho	3984	2	,	,	,
cord-006229-7yoilsho	3984	3	there	there	EX
cord-006229-7yoilsho	3984	4	were	be	VBD
cord-006229-7yoilsho	3984	5	quantitative	quantitative	JJ
cord-006229-7yoilsho	3984	6	differences	difference	NNS
cord-006229-7yoilsho	3984	7	between	between	IN
cord-006229-7yoilsho	3984	8	small	small	JJ
cord-006229-7yoilsho	3984	9	intestine	intestine	NN
cord-006229-7yoilsho	3984	10	and	and	CC
cord-006229-7yoilsho	3984	11	colon	colon	NN
cord-006229-7yoilsho	3984	12	.	.	.
cord-006229-7yoilsho	3985	1	As	as	IN
cord-006229-7yoilsho	3985	2	a	a	DT
cord-006229-7yoilsho	3985	3	consequence	consequence	NN
cord-006229-7yoilsho	3985	4	the	the	DT
cord-006229-7yoilsho	3985	5	question	question	NN
cord-006229-7yoilsho	3985	6	arose	arise	VBD
cord-006229-7yoilsho	3985	7	if	if	IN
cord-006229-7yoilsho	3985	8	this	this	DT
cord-006229-7yoilsho	3985	9	observation	observation	NN
cord-006229-7yoilsho	3985	10	could	could	MD
cord-006229-7yoilsho	3985	11	be	be	VB
cord-006229-7yoilsho	3985	12	explained	explain	VBN
cord-006229-7yoilsho	3985	13	by	by	IN
cord-006229-7yoilsho	3985	14	small	small	JJ
cord-006229-7yoilsho	3985	15	non	non	JJ
cord-006229-7yoilsho	3985	16	-	-	JJ
cord-006229-7yoilsho	3985	17	coding	coding	JJ
cord-006229-7yoilsho	3985	18	RNAs	rna	NNS
cord-006229-7yoilsho	3985	19	acting	act	VBG
cord-006229-7yoilsho	3985	20	as	as	IN
cord-006229-7yoilsho	3985	21	highly	highly	RB
cord-006229-7yoilsho	3985	22	tissue	tissue	NN
cord-006229-7yoilsho	3985	23	-	-	HYPH
cord-006229-7yoilsho	3985	24	specific	specific	JJ
cord-006229-7yoilsho	3985	25	posttranscriptional	posttranscriptional	JJ
cord-006229-7yoilsho	3985	26	regulators	regulator	NNS
cord-006229-7yoilsho	3985	27	of	of	IN
cord-006229-7yoilsho	3985	28	gene	gene	NN
cord-006229-7yoilsho	3985	29	expression	expression	NN
cord-006229-7yoilsho	3985	30	.	.	.
cord-006229-7yoilsho	3986	1	Hence	hence	RB
cord-006229-7yoilsho	3986	2	,	,	,
cord-006229-7yoilsho	3986	3	in	in	IN
cord-006229-7yoilsho	3986	4	our	-PRON-	PRP$
cord-006229-7yoilsho	3986	5	current	current	JJ
cord-006229-7yoilsho	3986	6	study	study	NN
cord-006229-7yoilsho	3986	7	,	,	,
cord-006229-7yoilsho	3986	8	we	-PRON-	PRP
cord-006229-7yoilsho	3986	9	aimed	aim	VBD
cord-006229-7yoilsho	3986	10	to	to	TO
cord-006229-7yoilsho	3986	11	investigate	investigate	VB
cord-006229-7yoilsho	3986	12	the	the	DT
cord-006229-7yoilsho	3986	13	impact	impact	NN
cord-006229-7yoilsho	3986	14	of	of	IN
cord-006229-7yoilsho	3986	15	miRNAs	miRNAs	NNP
cord-006229-7yoilsho	3986	16	on	on	IN
cord-006229-7yoilsho	3986	17	site	site	NN
cord-006229-7yoilsho	3986	18	-	-	HYPH
cord-006229-7yoilsho	3986	19	specific	specific	JJ
cord-006229-7yoilsho	3986	20	transporter	transporter	NN
cord-006229-7yoilsho	3986	21	expression	expression	NN
cord-006229-7yoilsho	3986	22	along	along	IN
cord-006229-7yoilsho	3986	23	the	the	DT
cord-006229-7yoilsho	3986	24	human	human	JJ
cord-006229-7yoilsho	3986	25	intestine	intestine	NN
cord-006229-7yoilsho	3986	26	.	.	.
cord-006229-7yoilsho	3987	1	Methods	method	NNS
cord-006229-7yoilsho	3987	2	:	:	:
cord-006229-7yoilsho	3987	3	Total	Total	NNP
cord-006229-7yoilsho	3987	4	RNA	RNA	NNP
cord-006229-7yoilsho	3987	5	was	be	VBD
cord-006229-7yoilsho	3987	6	isolated	isolate	VBN
cord-006229-7yoilsho	3987	7	from	from	IN
cord-006229-7yoilsho	3987	8	biopsies	biopsy	NNS
cord-006229-7yoilsho	3987	9	obtained	obtain	VBN
cord-006229-7yoilsho	3987	10	from	from	IN
cord-006229-7yoilsho	3987	11	six	six	CD
cord-006229-7yoilsho	3987	12	disease	disease	NN
cord-006229-7yoilsho	3987	13	-	-	HYPH
cord-006229-7yoilsho	3987	14	free	free	JJ
cord-006229-7yoilsho	3987	15	organ	organ	NN
cord-006229-7yoilsho	3987	16	donors	donor	NNS
cord-006229-7yoilsho	3987	17	.	.	.
cord-006229-7yoilsho	3988	1	Tissue	tissue	NN
cord-006229-7yoilsho	3988	2	samples	sample	NNS
cord-006229-7yoilsho	3988	3	were	be	VBD
cord-006229-7yoilsho	3988	4	acquired	acquire	VBN
cord-006229-7yoilsho	3988	5	from	from	IN
cord-006229-7yoilsho	3988	6	the	the	DT
cord-006229-7yoilsho	3988	7	duodenum	duodenum	NN
cord-006229-7yoilsho	3988	8	,	,	,
cord-006229-7yoilsho	3988	9	the	the	DT
cord-006229-7yoilsho	3988	10	upper	upper	JJ
cord-006229-7yoilsho	3988	11	and	and	CC
cord-006229-7yoilsho	3988	12	lower	low	JJR
cord-006229-7yoilsho	3988	13	jejunum	jejunum	NNS
cord-006229-7yoilsho	3988	14	,	,	,
cord-006229-7yoilsho	3988	15	the	the	DT
cord-006229-7yoilsho	3988	16	upper	upper	JJ
cord-006229-7yoilsho	3988	17	and	and	CC
cord-006229-7yoilsho	3988	18	lower	low	JJR
cord-006229-7yoilsho	3988	19	ileum	ileum	NN
cord-006229-7yoilsho	3988	20	,	,	,
cord-006229-7yoilsho	3988	21	and	and	CC
cord-006229-7yoilsho	3988	22	the	the	DT
cord-006229-7yoilsho	3988	23	transversal	transversal	JJ
cord-006229-7yoilsho	3988	24	or	or	CC
cord-006229-7yoilsho	3988	25	descending	descend	VBG
cord-006229-7yoilsho	3988	26	colon	colon	NN
cord-006229-7yoilsho	3988	27	.	.	.
cord-006229-7yoilsho	3989	1	The	the	DT
cord-006229-7yoilsho	3989	2	expression	expression	NN
cord-006229-7yoilsho	3989	3	of	of	IN
cord-006229-7yoilsho	3989	4	754	754	CD
cord-006229-7yoilsho	3989	5	miRNAs	miRNAs	NNP
cord-006229-7yoilsho	3989	6	was	be	VBD
cord-006229-7yoilsho	3989	7	measured	measure	VBN
cord-006229-7yoilsho	3989	8	using	use	VBG
cord-006229-7yoilsho	3989	9	rt	rt	NNP
cord-006229-7yoilsho	3989	10	-	-	HYPH
cord-006229-7yoilsho	3989	11	PCR	PCR	NNP
cord-006229-7yoilsho	3989	12	based	base	VBN
cord-006229-7yoilsho	3989	13	low	low	JJ
cord-006229-7yoilsho	3989	14	density	density	NN
cord-006229-7yoilsho	3989	15	arrays	array	NNS
cord-006229-7yoilsho	3989	16	.	.	.
cord-006229-7yoilsho	3990	1	Expression	expression	NN
cord-006229-7yoilsho	3990	2	of	of	IN
cord-006229-7yoilsho	3990	3	all	all	DT
cord-006229-7yoilsho	3990	4	detected	detect	VBN
cord-006229-7yoilsho	3990	5	miRNAs	miRNAs	NNP
cord-006229-7yoilsho	3990	6	was	be	VBD
cord-006229-7yoilsho	3990	7	correlated	correlate	VBN
cord-006229-7yoilsho	3990	8	with	with	IN
cord-006229-7yoilsho	3990	9	transporter	transporter	NN
cord-006229-7yoilsho	3990	10	protein	protein	NN
cord-006229-7yoilsho	3990	11	data	datum	NNS
cord-006229-7yoilsho	3990	12	recently	recently	RB
cord-006229-7yoilsho	3990	13	determined	determine	VBN
cord-006229-7yoilsho	3990	14	by	by	IN
cord-006229-7yoilsho	3990	15	LC	LC	NNP
cord-006229-7yoilsho	3990	16	-	-	HYPH
cord-006229-7yoilsho	3990	17	MS	MS	NNP
cord-006229-7yoilsho	3990	18	/	/	SYM
cord-006229-7yoilsho	3990	19	MS	MS	NNP
cord-006229-7yoilsho	3990	20	-	-	HYPH
cord-006229-7yoilsho	3990	21	based	base	VBN
cord-006229-7yoilsho	3990	22	targeted	target	VBN
cord-006229-7yoilsho	3990	23	proteomics	proteomic	NNS
cord-006229-7yoilsho	3990	24	.	.	.
cord-006229-7yoilsho	3991	1	miRNAs	miRNAs	NNP
cord-006229-7yoilsho	3991	2	and	and	CC
cord-006229-7yoilsho	3991	3	transporter	transporter	NN
cord-006229-7yoilsho	3991	4	genes	gene	NNS
cord-006229-7yoilsho	3991	5	showing	show	VBG
cord-006229-7yoilsho	3991	6	an	an	DT
cord-006229-7yoilsho	3991	7	inverse	inverse	JJ
cord-006229-7yoilsho	3991	8	Pearson	Pearson	NNP
cord-006229-7yoilsho	3991	9	's	's	POS
cord-006229-7yoilsho	3991	10	correlation	correlation	NN
cord-006229-7yoilsho	3991	11	between	between	IN
cord-006229-7yoilsho	3991	12	miRNA	miRNA	NNP
cord-006229-7yoilsho	3991	13	and	and	CC
cord-006229-7yoilsho	3991	14	protein	protein	NN
cord-006229-7yoilsho	3991	15	expression	expression	NN
cord-006229-7yoilsho	3991	16	underwent	undergo	VBD
cord-006229-7yoilsho	3991	17	an	an	DT
cord-006229-7yoilsho	3991	18	in	in	IN
cord-006229-7yoilsho	3991	19	-	-	HYPH
cord-006229-7yoilsho	3991	20	silico	silico	NN
cord-006229-7yoilsho	3991	21	search	search	NN
cord-006229-7yoilsho	3991	22	(	(	-LRB-
cord-006229-7yoilsho	3991	23	MicroCosm	MicroCosm	NNP
cord-006229-7yoilsho	3991	24	Targets	Targets	NNPS
cord-006229-7yoilsho	3991	25	v.5	v.5	NNP
cord-006229-7yoilsho	3991	26	,	,	,
cord-006229-7yoilsho	3991	27	TargetScan7.0	TargetScan7.0	NNP
cord-006229-7yoilsho	3991	28	)	)	-RRB-
cord-006229-7yoilsho	3991	29	for	for	IN
cord-006229-7yoilsho	3991	30	putative	putative	JJ
cord-006229-7yoilsho	3991	31	miRNA	miRNA	NNP
cord-006229-7yoilsho	3991	32	/	/	SYM
cord-006229-7yoilsho	3991	33	mRNA	mRNA	NNP
cord-006229-7yoilsho	3991	34	interaction	interaction	NN
cord-006229-7yoilsho	3991	35	.	.	.
cord-006229-7yoilsho	3992	1	To	to	TO
cord-006229-7yoilsho	3992	2	investigate	investigate	VB
cord-006229-7yoilsho	3992	3	those	those	DT
cord-006229-7yoilsho	3992	4	interactions	interaction	NNS
cord-006229-7yoilsho	3992	5	in	in	IN
cord-006229-7yoilsho	3992	6	more	more	JJR
cord-006229-7yoilsho	3992	7	detail	detail	NN
cord-006229-7yoilsho	3992	8	,	,	,
cord-006229-7yoilsho	3992	9	reporter	reporter	NN
cord-006229-7yoilsho	3992	10	gene	gene	NN
cord-006229-7yoilsho	3992	11	assays	assay	NNS
cord-006229-7yoilsho	3992	12	and	and	CC
cord-006229-7yoilsho	3992	13	site	site	NN
cord-006229-7yoilsho	3992	14	directed	direct	VBN
cord-006229-7yoilsho	3992	15	mutagenesis	mutagenesis	NN
cord-006229-7yoilsho	3992	16	were	be	VBD
cord-006229-7yoilsho	3992	17	conducted	conduct	VBN
cord-006229-7yoilsho	3992	18	.	.	.
cord-006229-7yoilsho	3993	1	Results	result	NNS
cord-006229-7yoilsho	3993	2	:	:	:
cord-006229-7yoilsho	3994	1	Out	out	IN
cord-006229-7yoilsho	3994	2	of	of	IN
cord-006229-7yoilsho	3994	3	754	754	CD
cord-006229-7yoilsho	3994	4	miRNAs	miRNAs	NNP
cord-006229-7yoilsho	3994	5	,	,	,
cord-006229-7yoilsho	3994	6	248	248	CD
cord-006229-7yoilsho	3994	7	were	be	VBD
cord-006229-7yoilsho	3994	8	detected	detect	VBN
cord-006229-7yoilsho	3994	9	in	in	IN
cord-006229-7yoilsho	3994	10	all	all	DT
cord-006229-7yoilsho	3994	11	tissue	tissue	NN
cord-006229-7yoilsho	3994	12	types	type	NNS
cord-006229-7yoilsho	3994	13	.	.	.
cord-006229-7yoilsho	3995	1	Out	out	IN
cord-006229-7yoilsho	3995	2	of	of	IN
cord-006229-7yoilsho	3995	3	ten	ten	CD
cord-006229-7yoilsho	3995	4	transporters	transporter	NNS
cord-006229-7yoilsho	3995	5	five	five	CD
cord-006229-7yoilsho	3995	6	showed	show	VBD
cord-006229-7yoilsho	3995	7	significant	significant	JJ
cord-006229-7yoilsho	3995	8	inverse	inverse	JJ
cord-006229-7yoilsho	3995	9	correlations	correlation	NNS
cord-006229-7yoilsho	3995	10	with	with	IN
cord-006229-7yoilsho	3995	11	10	10	CD
cord-006229-7yoilsho	3995	12	putatively	putatively	RB
cord-006229-7yoilsho	3995	13	targeting	target	VBG
cord-006229-7yoilsho	3995	14	miRNAs	miRNAs	NNP
cord-006229-7yoilsho	3995	15	(	(	-LRB-
cord-006229-7yoilsho	3995	16	e.g.	e.g.	RB
cord-006229-7yoilsho	3995	17	PEPT1	PEPT1	NNP
cord-006229-7yoilsho	3995	18	and	and	CC
cord-006229-7yoilsho	3995	19	hsa	hsa	NNP
cord-006229-7yoilsho	3995	20	-	-	HYPH
cord-006229-7yoilsho	3995	21	miR-27a	miR-27a	NNP
cord-006229-7yoilsho	3995	22	,	,	,
cord-006229-7yoilsho	3995	23	r=	r=	NNP
cord-006229-7yoilsho	3995	24	-0.498	-0.498	NNP
cord-006229-7yoilsho	3995	25	,	,	,
cord-006229-7yoilsho	3995	26	p=0.002	p=0.002	NNP
cord-006229-7yoilsho	3995	27	)	)	-RRB-
cord-006229-7yoilsho	3995	28	.	.	.
cord-006229-7yoilsho	3996	1	Reporter	reporter	NN
cord-006229-7yoilsho	3996	2	gene	gene	NN
cord-006229-7yoilsho	3996	3	assays	assay	NNS
cord-006229-7yoilsho	3996	4	indicated	indicate	VBD
cord-006229-7yoilsho	3996	5	interactions	interaction	NNS
cord-006229-7yoilsho	3996	6	of	of	IN
cord-006229-7yoilsho	3996	7	miR-193a	miR-193a	NNS
cord-006229-7yoilsho	3996	8	/	/	SYM
cord-006229-7yoilsho	3996	9	b	b	NN
cord-006229-7yoilsho	3996	10	with	with	IN
cord-006229-7yoilsho	3996	11	PEPT1	pept1	NN
cord-006229-7yoilsho	3996	12	3'-UTR	3'-utr	CD
cord-006229-7yoilsho	3997	1	(	(	-LRB-
cord-006229-7yoilsho	3997	2	p	p	NN
cord-006229-7yoilsho	3997	3	=	=	SYM
cord-006229-7yoilsho	3997	4	0.0025	0.0025	CD
cord-006229-7yoilsho	3997	5	and	and	CC
cord-006229-7yoilsho	3997	6	p	p	NN
cord-006229-7yoilsho	3997	7	=	=	SYM
cord-006229-7yoilsho	3997	8	0.0012	0.0012	CD
cord-006229-7yoilsho	3997	9	)	)	-RRB-
cord-006229-7yoilsho	3997	10	as	as	RB
cord-006229-7yoilsho	3997	11	well	well	RB
cord-006229-7yoilsho	3997	12	as	as	IN
cord-006229-7yoilsho	3997	13	of	of	IN
cord-006229-7yoilsho	3997	14	miR-27a	miR-27a	NNP
cord-006229-7yoilsho	3997	15	with	with	IN
cord-006229-7yoilsho	3997	16	ABCB1	ABCB1	NNP
cord-006229-7yoilsho	3997	17	3'-UTR	3'-utr	CD
cord-006229-7yoilsho	3998	1	(	(	-LRB-
cord-006229-7yoilsho	3998	2	p	p	NN
cord-006229-7yoilsho	3998	3	=	=	SYM
cord-006229-7yoilsho	3998	4	0.0006	0.0006	CD
cord-006229-7yoilsho	3998	5	)	)	-RRB-
cord-006229-7yoilsho	3998	6	.	.	.
cord-006229-7yoilsho	3999	1	The	the	DT
cord-006229-7yoilsho	3999	2	site	site	NN
cord-006229-7yoilsho	3999	3	-	-	HYPH
cord-006229-7yoilsho	3999	4	specific	specific	JJ
cord-006229-7yoilsho	3999	5	abundance	abundance	NN
cord-006229-7yoilsho	3999	6	of	of	IN
cord-006229-7yoilsho	3999	7	intestinal	intestinal	JJ
cord-006229-7yoilsho	3999	8	drug	drug	NN
cord-006229-7yoilsho	3999	9	transporters	transporter	NNS
cord-006229-7yoilsho	3999	10	is	be	VBZ
cord-006229-7yoilsho	3999	11	significantly	significantly	RB
cord-006229-7yoilsho	3999	12	affected	affect	VBN
cord-006229-7yoilsho	3999	13	by	by	IN
cord-006229-7yoilsho	3999	14	microRNA	microRNA	NNP
cord-006229-7yoilsho	3999	15	-	-	HYPH
cord-006229-7yoilsho	3999	16	mediated	mediate	VBN
cord-006229-7yoilsho	3999	17	post	post	JJ
cord-006229-7yoilsho	3999	18	-	-	JJ
cord-006229-7yoilsho	3999	19	transcriptional	transcriptional	JJ
cord-006229-7yoilsho	3999	20	regulation	regulation	NN
cord-006229-7yoilsho	3999	21	under	under	IN
cord-006229-7yoilsho	3999	22	physiological	physiological	JJ
cord-006229-7yoilsho	3999	23	conditions	condition	NNS
cord-006229-7yoilsho	3999	24	as	as	IN
cord-006229-7yoilsho	3999	25	exemplified	exemplify	VBN
cord-006229-7yoilsho	3999	26	for	for	IN
cord-006229-7yoilsho	3999	27	PEPT1	pept1	NN
cord-006229-7yoilsho	4000	1	and	and	CC
cord-006229-7yoilsho	4000	2	ABCB1	ABCB1	NNP
cord-006229-7yoilsho	4000	3	.	.	.
cord-006229-7yoilsho	4001	1	Background	background	NN
cord-006229-7yoilsho	4001	2	:	:	:
cord-006229-7yoilsho	4002	1	The	the	DT
cord-006229-7yoilsho	4002	2	human	human	JJ
cord-006229-7yoilsho	4002	3	uptake	uptake	NN
cord-006229-7yoilsho	4002	4	transporter	transporter	NN
cord-006229-7yoilsho	4002	5	NaCT	NaCT	NNP
cord-006229-7yoilsho	4002	6	[	[	-LRB-
cord-006229-7yoilsho	4002	7	gene	gene	NN
cord-006229-7yoilsho	4002	8	symbol	symbol	NN
cord-006229-7yoilsho	4002	9	SLC13A5	SLC13A5	NNP
cord-006229-7yoilsho	4002	10	;	;	:
cord-006229-7yoilsho	4002	11	also	also	RB
cord-006229-7yoilsho	4002	12	known	know	VBN
cord-006229-7yoilsho	4002	13	as	as	IN
cord-006229-7yoilsho	4002	14	mINDY	mINDY	NNP
cord-006229-7yoilsho	4002	15	,	,	,
cord-006229-7yoilsho	4002	16	the	the	DT
cord-006229-7yoilsho	4002	17	human	human	JJ
cord-006229-7yoilsho	4002	18	orthologue	orthologue	NN
cord-006229-7yoilsho	4002	19	of	of	IN
cord-006229-7yoilsho	4002	20	the	the	DT
cord-006229-7yoilsho	4002	21	Drosophila	Drosophila	NNP
cord-006229-7yoilsho	4002	22	Indy	Indy	NNP
cord-006229-7yoilsho	4002	23	(	(	-LRB-
cord-006229-7yoilsho	4002	24	I´m	I´m	NNP
cord-006229-7yoilsho	4002	25	not	not	RB
cord-006229-7yoilsho	4002	26	dead	dead	JJ
cord-006229-7yoilsho	4002	27	yet	yet	RB
cord-006229-7yoilsho	4003	1	)	)	-RRB-
cord-006229-7yoilsho	4003	2	transporter	transporter	NN
cord-006229-7yoilsho	4003	3	]	]	-RRB-
cord-006229-7yoilsho	4003	4	is	be	VBZ
cord-006229-7yoilsho	4003	5	expressed	express	VBN
cord-006229-7yoilsho	4003	6	in	in	IN
cord-006229-7yoilsho	4003	7	liver	liver	NN
cord-006229-7yoilsho	4003	8	and	and	CC
cord-006229-7yoilsho	4003	9	brain	brain	NN
cord-006229-7yoilsho	4003	10	.	.	.
cord-006229-7yoilsho	4004	1	NaCT	NaCT	NNP
cord-006229-7yoilsho	4004	2	is	be	VBZ
cord-006229-7yoilsho	4004	3	important	important	JJ
cord-006229-7yoilsho	4004	4	for	for	IN
cord-006229-7yoilsho	4004	5	energy	energy	NN
cord-006229-7yoilsho	4004	6	metabolism	metabolism	NN
cord-006229-7yoilsho	4004	7	and	and	CC
cord-006229-7yoilsho	4004	8	brain	brain	NN
cord-006229-7yoilsho	4004	9	development	development	NN
cord-006229-7yoilsho	4004	10	and	and	CC
cord-006229-7yoilsho	4004	11	mediates	mediate	VBZ
cord-006229-7yoilsho	4004	12	the	the	DT
cord-006229-7yoilsho	4004	13	uptake	uptake	NN
cord-006229-7yoilsho	4004	14	of	of	IN
cord-006229-7yoilsho	4004	15	tricarboxylic	tricarboxylic	NNP
cord-006229-7yoilsho	4004	16	acid	acid	NN
cord-006229-7yoilsho	4004	17	(	(	-LRB-
cord-006229-7yoilsho	4004	18	TCA	TCA	NNP
cord-006229-7yoilsho	4004	19	)	)	-RRB-
cord-006229-7yoilsho	4004	20	intermediate	intermediate	JJ
cord-006229-7yoilsho	4004	21	such	such	JJ
cord-006229-7yoilsho	4004	22	as	as	IN
cord-006229-7yoilsho	4004	23	citrate	citrate	NN
cord-006229-7yoilsho	4004	24	and	and	CC
cord-006229-7yoilsho	4004	25	succinate	succinate	NNP
cord-006229-7yoilsho	4004	26	.	.	.
cord-006229-7yoilsho	4005	1	Reduced	reduce	VBN
cord-006229-7yoilsho	4005	2	expression	expression	NN
cord-006229-7yoilsho	4005	3	of	of	IN
cord-006229-7yoilsho	4005	4	this	this	DT
cord-006229-7yoilsho	4005	5	transporter	transporter	NN
cord-006229-7yoilsho	4005	6	,	,	,
cord-006229-7yoilsho	4005	7	as	as	IN
cord-006229-7yoilsho	4005	8	studied	study	VBN
cord-006229-7yoilsho	4005	9	in	in	IN
cord-006229-7yoilsho	4005	10	knock	knock	VB
cord-006229-7yoilsho	4005	11	-	-	HYPH
cord-006229-7yoilsho	4005	12	out	out	RP
cord-006229-7yoilsho	4005	13	mice	mouse	NNS
cord-006229-7yoilsho	4005	14	,	,	,
cord-006229-7yoilsho	4005	15	mimics	mimic	VBZ
cord-006229-7yoilsho	4005	16	aspects	aspect	NNS
cord-006229-7yoilsho	4005	17	of	of	IN
cord-006229-7yoilsho	4005	18	dietary	dietary	JJ
cord-006229-7yoilsho	4005	19	restriction	restriction	NN
cord-006229-7yoilsho	4005	20	,	,	,
cord-006229-7yoilsho	4005	21	promotes	promote	VBZ
cord-006229-7yoilsho	4005	22	longevity	longevity	NN
cord-006229-7yoilsho	4005	23	and	and	CC
cord-006229-7yoilsho	4005	24	protects	protect	VBZ
cord-006229-7yoilsho	4005	25	against	against	IN
cord-006229-7yoilsho	4005	26	insulin	insulin	NN
cord-006229-7yoilsho	4005	27	resistance	resistance	NN
cord-006229-7yoilsho	4005	28	and	and	CC
cord-006229-7yoilsho	4005	29	adiposity	adiposity	NN
cord-006229-7yoilsho	4005	30	.	.	.
cord-006229-7yoilsho	4006	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	4006	2	,	,	,
cord-006229-7yoilsho	4006	3	mutations	mutation	NNS
cord-006229-7yoilsho	4006	4	in	in	IN
cord-006229-7yoilsho	4006	5	the	the	DT
cord-006229-7yoilsho	4006	6	human	human	JJ
cord-006229-7yoilsho	4006	7	SLC13A5	slc13a5	JJ
cord-006229-7yoilsho	4006	8	gene	gene	NN
cord-006229-7yoilsho	4006	9	are	be	VBP
cord-006229-7yoilsho	4006	10	associated	associate	VBN
cord-006229-7yoilsho	4006	11	with	with	IN
cord-006229-7yoilsho	4006	12	epileptic	epileptic	JJ
cord-006229-7yoilsho	4006	13	encephalopathy	encephalopathy	NN
cord-006229-7yoilsho	4006	14	with	with	IN
cord-006229-7yoilsho	4006	15	seizure	seizure	NN
cord-006229-7yoilsho	4006	16	onset	onset	NN
cord-006229-7yoilsho	4006	17	in	in	IN
cord-006229-7yoilsho	4006	18	the	the	DT
cord-006229-7yoilsho	4006	19	first	first	JJ
cord-006229-7yoilsho	4006	20	days	day	NNS
cord-006229-7yoilsho	4006	21	of	of	IN
cord-006229-7yoilsho	4006	22	life	life	NN
cord-006229-7yoilsho	4006	23	,	,	,
cord-006229-7yoilsho	4006	24	possibly	possibly	RB
cord-006229-7yoilsho	4006	25	due	due	IN
cord-006229-7yoilsho	4006	26	to	to	IN
cord-006229-7yoilsho	4006	27	the	the	DT
cord-006229-7yoilsho	4006	28	reduced	reduce	VBN
cord-006229-7yoilsho	4006	29	uptake	uptake	NN
cord-006229-7yoilsho	4006	30	of	of	IN
cord-006229-7yoilsho	4006	31	TCA	TCA	NNP
cord-006229-7yoilsho	4006	32	intermediates	intermediate	NNS
cord-006229-7yoilsho	4006	33	into	into	IN
cord-006229-7yoilsho	4006	34	neurons	neuron	NNS
cord-006229-7yoilsho	4006	35	.	.	.
cord-006229-7yoilsho	4007	1	To	to	TO
cord-006229-7yoilsho	4007	2	gain	gain	VB
cord-006229-7yoilsho	4007	3	more	more	JJR
cord-006229-7yoilsho	4007	4	insights	insight	NNS
cord-006229-7yoilsho	4007	5	into	into	IN
cord-006229-7yoilsho	4007	6	the	the	DT
cord-006229-7yoilsho	4007	7	role	role	NN
cord-006229-7yoilsho	4007	8	of	of	IN
cord-006229-7yoilsho	4007	9	NaCT	NaCT	NNP
cord-006229-7yoilsho	4007	10	in	in	IN
cord-006229-7yoilsho	4007	11	drug	drug	NN
cord-006229-7yoilsho	4007	12	transport	transport	NN
cord-006229-7yoilsho	4007	13	and	and	CC
cord-006229-7yoilsho	4007	14	into	into	IN
cord-006229-7yoilsho	4007	15	structure	structure	NN
cord-006229-7yoilsho	4007	16	-	-	HYPH
cord-006229-7yoilsho	4007	17	function	function	NN
cord-006229-7yoilsho	4007	18	relationships	relationship	NNS
cord-006229-7yoilsho	4007	19	,	,	,
cord-006229-7yoilsho	4007	20	we	-PRON-	PRP
cord-006229-7yoilsho	4007	21	studied	study	VBD
cord-006229-7yoilsho	4007	22	the	the	DT
cord-006229-7yoilsho	4007	23	inhibition	inhibition	NN
cord-006229-7yoilsho	4007	24	of	of	IN
cord-006229-7yoilsho	4007	25	NaCT	NaCT	NNP
cord-006229-7yoilsho	4007	26	-	-	HYPH
cord-006229-7yoilsho	4007	27	mediated	mediate	VBN
cord-006229-7yoilsho	4007	28	citrate	citrate	NN
cord-006229-7yoilsho	4007	29	transport	transport	NN
cord-006229-7yoilsho	4007	30	by	by	IN
cord-006229-7yoilsho	4007	31	various	various	JJ
cord-006229-7yoilsho	4007	32	drugs	drug	NNS
cord-006229-7yoilsho	4007	33	and	and	CC
cord-006229-7yoilsho	4007	34	analyzed	analyze	VBD
cord-006229-7yoilsho	4007	35	the	the	DT
cord-006229-7yoilsho	4007	36	effect	effect	NN
cord-006229-7yoilsho	4007	37	of	of	IN
cord-006229-7yoilsho	4007	38	known	know	VBN
cord-006229-7yoilsho	4007	39	mutations	mutation	NNS
cord-006229-7yoilsho	4007	40	in	in	IN
cord-006229-7yoilsho	4007	41	the	the	DT
cord-006229-7yoilsho	4007	42	SLC13A5	slc13a5	JJ
cord-006229-7yoilsho	4007	43	gene	gene	NN
cord-006229-7yoilsho	4007	44	on	on	IN
cord-006229-7yoilsho	4007	45	NaCT	NaCT	NNP
cord-006229-7yoilsho	4007	46	-	-	HYPH
cord-006229-7yoilsho	4007	47	mediated	mediate	VBN
cord-006229-7yoilsho	4007	48	transport	transport	NN
cord-006229-7yoilsho	4007	49	.	.	.
cord-006229-7yoilsho	4008	1	Methods	method	NNS
cord-006229-7yoilsho	4008	2	:	:	:
cord-006229-7yoilsho	4009	1	Drug	drug	NN
cord-006229-7yoilsho	4009	2	inhibition	inhibition	NN
cord-006229-7yoilsho	4009	3	studies	study	NNS
cord-006229-7yoilsho	4009	4	were	be	VBD
cord-006229-7yoilsho	4009	5	performed	perform	VBN
cord-006229-7yoilsho	4009	6	using	use	VBG
cord-006229-7yoilsho	4009	7	HEK	HEK	NNP
cord-006229-7yoilsho	4009	8	cells	cell	NNS
cord-006229-7yoilsho	4009	9	stably	stably	RB
cord-006229-7yoilsho	4009	10	expressing	express	VBG
cord-006229-7yoilsho	4009	11	human	human	JJ
cord-006229-7yoilsho	4009	12	NaCT	nact	NN
cord-006229-7yoilsho	4009	13	with	with	IN
cord-006229-7yoilsho	4009	14	citrate	citrate	NNP
cord-006229-7yoilsho	4009	15	as	as	IN
cord-006229-7yoilsho	4009	16	prototypic	prototypic	NNP
cord-006229-7yoilsho	4009	17	substrate	substrate	NN
cord-006229-7yoilsho	4009	18	.	.	.
cord-006229-7yoilsho	4010	1	Twenty	twenty	CD
cord-006229-7yoilsho	4010	2	-	-	HYPH
cord-006229-7yoilsho	4010	3	four	four	CD
cord-006229-7yoilsho	4010	4	drugs	drug	NNS
cord-006229-7yoilsho	4010	5	were	be	VBD
cord-006229-7yoilsho	4010	6	used	use	VBN
cord-006229-7yoilsho	4010	7	as	as	IN
cord-006229-7yoilsho	4010	8	potential	potential	JJ
cord-006229-7yoilsho	4010	9	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	4010	10	of	of	IN
cord-006229-7yoilsho	4010	11	NaCT	nact	NN
cord-006229-7yoilsho	4010	12	-	-	HYPH
cord-006229-7yoilsho	4010	13	mediated	mediate	VBN
cord-006229-7yoilsho	4010	14	uptake	uptake	NN
cord-006229-7yoilsho	4010	15	.	.	.
cord-006229-7yoilsho	4011	1	The	the	DT
cord-006229-7yoilsho	4011	2	effects	effect	NNS
cord-006229-7yoilsho	4011	3	of	of	IN
cord-006229-7yoilsho	4011	4	eight	eight	CD
cord-006229-7yoilsho	4011	5	mutations	mutation	NNS
cord-006229-7yoilsho	4011	6	,	,	,
cord-006229-7yoilsho	4011	7	three	three	CD
cord-006229-7yoilsho	4011	8	of	of	IN
cord-006229-7yoilsho	4011	9	them	-PRON-	PRP
cord-006229-7yoilsho	4011	10	(	(	-LRB-
cord-006229-7yoilsho	4011	11	NaCTp	NaCTp	NNP
cord-006229-7yoilsho	4011	12	.	.	.
cord-006229-7yoilsho	4012	1	G219R	G219R	NNP
cord-006229-7yoilsho	4012	2	,	,	,
cord-006229-7yoilsho	4012	3	-p	-p	ADD
cord-006229-7yoilsho	4012	4	.	.	.
cord-006229-7yoilsho	4013	1	T227	T227	NNP
cord-006229-7yoilsho	4013	2	M	m	NN
cord-006229-7yoilsho	4013	3	and	and	CC
cord-006229-7yoilsho	4013	4	-p	-p	VBZ
cord-006229-7yoilsho	4013	5	.	.	.
cord-006229-7yoilsho	4014	1	L488P	L488P	NNP
cord-006229-7yoilsho	4014	2	)	)	-RRB-
cord-006229-7yoilsho	4014	3	associated	associate	VBN
cord-006229-7yoilsho	4014	4	with	with	IN
cord-006229-7yoilsho	4014	5	epileptic	epileptic	JJ
cord-006229-7yoilsho	4014	6	encephalopathy	encephalopathy	NN
cord-006229-7yoilsho	4014	7	,	,	,
cord-006229-7yoilsho	4014	8	were	be	VBD
cord-006229-7yoilsho	4014	9	analyzed	analyze	VBN
cord-006229-7yoilsho	4014	10	using	use	VBG
cord-006229-7yoilsho	4014	11	a	a	DT
cord-006229-7yoilsho	4014	12	transient	transient	JJ
cord-006229-7yoilsho	4014	13	transfection	transfection	NN
cord-006229-7yoilsho	4014	14	approach	approach	NN
cord-006229-7yoilsho	4014	15	.	.	.
cord-006229-7yoilsho	4015	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	4015	2	,	,	,
cord-006229-7yoilsho	4015	3	the	the	DT
cord-006229-7yoilsho	4015	4	first	first	JJ
cord-006229-7yoilsho	4015	5	computational	computational	NN
cord-006229-7yoilsho	4015	6	-	-	HYPH
cord-006229-7yoilsho	4015	7	based	base	VBN
cord-006229-7yoilsho	4015	8	structural	structural	JJ
cord-006229-7yoilsho	4015	9	model	model	NN
cord-006229-7yoilsho	4015	10	of	of	IN
cord-006229-7yoilsho	4015	11	the	the	DT
cord-006229-7yoilsho	4015	12	NaCT	NaCT	NNP
cord-006229-7yoilsho	4015	13	transporter	transporter	NN
cord-006229-7yoilsho	4015	14	was	be	VBD
cord-006229-7yoilsho	4015	15	established	establish	VBN
cord-006229-7yoilsho	4015	16	and	and	CC
cord-006229-7yoilsho	4015	17	the	the	DT
cord-006229-7yoilsho	4015	18	impact	impact	NN
cord-006229-7yoilsho	4015	19	of	of	IN
cord-006229-7yoilsho	4015	20	all	all	DT
cord-006229-7yoilsho	4015	21	mutations	mutation	NNS
cord-006229-7yoilsho	4015	22	on	on	IN
cord-006229-7yoilsho	4015	23	substrate	substrate	JJ
cord-006229-7yoilsho	4015	24	transport	transport	NN
cord-006229-7yoilsho	4015	25	was	be	VBD
cord-006229-7yoilsho	4015	26	modeled	model	VBN
cord-006229-7yoilsho	4015	27	.	.	.
cord-006229-7yoilsho	4016	1	Results	result	NNS
cord-006229-7yoilsho	4016	2	:	:	:
cord-006229-7yoilsho	4017	1	Inhibitions	inhibition	NNS
cord-006229-7yoilsho	4017	2	studies	study	NNS
cord-006229-7yoilsho	4017	3	demonstrated	demonstrate	VBD
cord-006229-7yoilsho	4017	4	that	that	IN
cord-006229-7yoilsho	4017	5	only	only	RB
cord-006229-7yoilsho	4017	6	a	a	DT
cord-006229-7yoilsho	4017	7	few	few	JJ
cord-006229-7yoilsho	4017	8	drugs	drug	NNS
cord-006229-7yoilsho	4017	9	(	(	-LRB-
cord-006229-7yoilsho	4017	10	three	three	CD
cord-006229-7yoilsho	4017	11	out	out	IN
cord-006229-7yoilsho	4017	12	of	of	IN
cord-006229-7yoilsho	4017	13	24	24	CD
cord-006229-7yoilsho	4017	14	tested	test	VBN
cord-006229-7yoilsho	4017	15	)	)	-RRB-
cord-006229-7yoilsho	4017	16	inhibited	inhibit	VBN
cord-006229-7yoilsho	4017	17	NaCT	nact	NN
cord-006229-7yoilsho	4017	18	-	-	HYPH
cord-006229-7yoilsho	4017	19	mediated	mediate	VBN
cord-006229-7yoilsho	4017	20	citrate	citrate	NN
cord-006229-7yoilsho	4017	21	transport	transport	NN
cord-006229-7yoilsho	4017	22	at	at	IN
cord-006229-7yoilsho	4017	23	the	the	DT
cord-006229-7yoilsho	4017	24	tested	test	VBN
cord-006229-7yoilsho	4017	25	drug	drug	NN
cord-006229-7yoilsho	4017	26	concentration	concentration	NN
cord-006229-7yoilsho	4017	27	of	of	IN
cord-006229-7yoilsho	4017	28	100	100	CD
cord-006229-7yoilsho	4017	29	µM.	µm.	NN
cord-006229-7yoilsho	4017	30	From	from	IN
cord-006229-7yoilsho	4017	31	these	these	DT
cord-006229-7yoilsho	4017	32	,	,	,
cord-006229-7yoilsho	4017	33	benzbromarone	benzbromarone	NN
cord-006229-7yoilsho	4017	34	shows	show	VBZ
cord-006229-7yoilsho	4017	35	the	the	DT
cord-006229-7yoilsho	4017	36	strongest	strong	JJS
cord-006229-7yoilsho	4017	37	inhibition	inhibition	NN
cord-006229-7yoilsho	4017	38	with	with	IN
cord-006229-7yoilsho	4017	39	an	an	DT
cord-006229-7yoilsho	4017	40	IC	IC	NNP
cord-006229-7yoilsho	4017	41	50	50	CD
cord-006229-7yoilsho	4017	42	value	value	NN
cord-006229-7yoilsho	4017	43	of	of	IN
cord-006229-7yoilsho	4017	44	83.2	83.2	CD
cord-006229-7yoilsho	4017	45	µM.	µm.	JJ
cord-006229-7yoilsho	4018	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	4018	2	,	,	,
cord-006229-7yoilsho	4018	3	citrate	citrate	NN
cord-006229-7yoilsho	4018	4	transport	transport	NN
cord-006229-7yoilsho	4018	5	was	be	VBD
cord-006229-7yoilsho	4018	6	also	also	RB
cord-006229-7yoilsho	4018	7	slightly	slightly	RB
cord-006229-7yoilsho	4018	8	inhibited	inhibit	VBN
cord-006229-7yoilsho	4018	9	by	by	IN
cord-006229-7yoilsho	4018	10	pioglitazone	pioglitazone	NN
cord-006229-7yoilsho	4018	11	and	and	CC
cord-006229-7yoilsho	4018	12	rosiglitazone	rosiglitazone	NN
cord-006229-7yoilsho	4018	13	.	.	.
cord-006229-7yoilsho	4019	1	Citrate	Citrate	NNP
cord-006229-7yoilsho	4019	2	transport	transport	NN
cord-006229-7yoilsho	4019	3	of	of	IN
cord-006229-7yoilsho	4019	4	the	the	DT
cord-006229-7yoilsho	4019	5	mutated	mutate	VBN
cord-006229-7yoilsho	4019	6	proteins	protein	NNS
cord-006229-7yoilsho	4019	7	NaCTp	NaCTp	NNP
cord-006229-7yoilsho	4019	8	.	.	.
cord-006229-7yoilsho	4020	1	G219R	G219R	NNP
cord-006229-7yoilsho	4020	2	,	,	,
cord-006229-7yoilsho	4020	3	-p	-p	ADD
cord-006229-7yoilsho	4020	4	.	.	.
cord-006229-7yoilsho	4021	1	G219E	G219E	NNP
cord-006229-7yoilsho	4021	2	,	,	,
cord-006229-7yoilsho	4021	3	p	p	NN
cord-006229-7yoilsho	4021	4	.	.	.
cord-006229-7yoilsho	4022	1	T227	T227	NNP
cord-006229-7yoilsho	4022	2	M	M	NNP
cord-006229-7yoilsho	4022	3	,	,	,
cord-006229-7yoilsho	4022	4	-p	-p	VBZ
cord-006229-7yoilsho	4022	5	.	.	.
cord-006229-7yoilsho	4023	1	L420P	L420P	NNS
cord-006229-7yoilsho	4023	2	and	and	CC
cord-006229-7yoilsho	4023	3	-p	-p	NN
cord-006229-7yoilsho	4023	4	.	.	.
cord-006229-7yoilsho	4024	1	L488P	L488P	NNP
cord-006229-7yoilsho	4024	2	was	be	VBD
cord-006229-7yoilsho	4024	3	totally	totally	RB
cord-006229-7yoilsho	4024	4	abolished	abolish	VBN
cord-006229-7yoilsho	4024	5	and	and	CC
cord-006229-7yoilsho	4024	6	the	the	DT
cord-006229-7yoilsho	4024	7	effect	effect	NN
cord-006229-7yoilsho	4024	8	of	of	IN
cord-006229-7yoilsho	4024	9	these	these	DT
cord-006229-7yoilsho	4024	10	mutations	mutation	NNS
cord-006229-7yoilsho	4024	11	could	could	MD
cord-006229-7yoilsho	4024	12	be	be	VB
cord-006229-7yoilsho	4024	13	explained	explain	VBN
cord-006229-7yoilsho	4024	14	on	on	IN
cord-006229-7yoilsho	4024	15	the	the	DT
cord-006229-7yoilsho	4024	16	basis	basis	NN
cord-006229-7yoilsho	4024	17	of	of	IN
cord-006229-7yoilsho	4024	18	the	the	DT
cord-006229-7yoilsho	4024	19	structural	structural	JJ
cord-006229-7yoilsho	4024	20	model	model	NN
cord-006229-7yoilsho	4024	21	.	.	.
cord-006229-7yoilsho	4025	1	Conclusion	conclusion	NN
cord-006229-7yoilsho	4025	2	:	:	:
cord-006229-7yoilsho	4026	1	Inhibition	inhibition	NN
cord-006229-7yoilsho	4026	2	studies	study	NNS
cord-006229-7yoilsho	4026	3	demonstrated	demonstrate	VBD
cord-006229-7yoilsho	4026	4	that	that	IN
cord-006229-7yoilsho	4026	5	simultaneously	simultaneously	RB
cord-006229-7yoilsho	4026	6	administered	administer	VBN
cord-006229-7yoilsho	4026	7	drugs	drug	NNS
cord-006229-7yoilsho	4026	8	can	can	MD
cord-006229-7yoilsho	4026	9	inhibit	inhibit	VB
cord-006229-7yoilsho	4026	10	NaCT	nact	NN
cord-006229-7yoilsho	4026	11	-	-	HYPH
cord-006229-7yoilsho	4026	12	mediated	mediate	VBN
cord-006229-7yoilsho	4026	13	uptake	uptake	NN
cord-006229-7yoilsho	4026	14	of	of	IN
cord-006229-7yoilsho	4026	15	the	the	DT
cord-006229-7yoilsho	4026	16	prototypic	prototypic	NNP
cord-006229-7yoilsho	4026	17	substrate	substrate	NNP
cord-006229-7yoilsho	4026	18	citrate	citrate	NNP
cord-006229-7yoilsho	4026	19	.	.	.
cord-006229-7yoilsho	4027	1	NaCT	NaCT	NNP
cord-006229-7yoilsho	4027	2	-	-	HYPH
cord-006229-7yoilsho	4027	3	mediated	mediate	VBN
cord-006229-7yoilsho	4027	4	uptake	uptake	NN
cord-006229-7yoilsho	4027	5	is	be	VBZ
cord-006229-7yoilsho	4027	6	abolished	abolish	VBN
cord-006229-7yoilsho	4027	7	by	by	IN
cord-006229-7yoilsho	4027	8	mutations	mutation	NNS
cord-006229-7yoilsho	4027	9	in	in	IN
cord-006229-7yoilsho	4027	10	the	the	DT
cord-006229-7yoilsho	4027	11	SLC13A5	slc13a5	JJ
cord-006229-7yoilsho	4027	12	gene	gene	NN
cord-006229-7yoilsho	4027	13	associated	associate	VBN
cord-006229-7yoilsho	4027	14	with	with	IN
cord-006229-7yoilsho	4027	15	epileptic	epileptic	JJ
cord-006229-7yoilsho	4027	16	encephalopathy	encephalopathy	NN
cord-006229-7yoilsho	4027	17	.	.	.
cord-006229-7yoilsho	4028	1	The	the	DT
cord-006229-7yoilsho	4028	2	effect	effect	NN
cord-006229-7yoilsho	4028	3	of	of	IN
cord-006229-7yoilsho	4028	4	these	these	DT
cord-006229-7yoilsho	4028	5	mutations	mutation	NNS
cord-006229-7yoilsho	4028	6	can	can	MD
cord-006229-7yoilsho	4028	7	be	be	VB
cord-006229-7yoilsho	4028	8	explained	explain	VBN
cord-006229-7yoilsho	4028	9	on	on	IN
cord-006229-7yoilsho	4028	10	the	the	DT
cord-006229-7yoilsho	4028	11	basis	basis	NN
cord-006229-7yoilsho	4028	12	of	of	IN
cord-006229-7yoilsho	4028	13	the	the	DT
cord-006229-7yoilsho	4028	14	first	first	JJ
cord-006229-7yoilsho	4028	15	structural	structural	JJ
cord-006229-7yoilsho	4028	16	model	model	NN
cord-006229-7yoilsho	4028	17	of	of	IN
cord-006229-7yoilsho	4028	18	this	this	DT
cord-006229-7yoilsho	4028	19	uptake	uptake	NN
cord-006229-7yoilsho	4028	20	transporter	transporter	NN
cord-006229-7yoilsho	4028	21	.	.	.
cord-006229-7yoilsho	4029	1	The	the	DT
cord-006229-7yoilsho	4029	2	ATP	ATP	NNP
cord-006229-7yoilsho	4029	3	-	-	HYPH
cord-006229-7yoilsho	4029	4	binding	bind	VBG
cord-006229-7yoilsho	4029	5	cassette	cassette	NN
cord-006229-7yoilsho	4029	6	subfamily	subfamily	NN
cord-006229-7yoilsho	4029	7	B	b	NN
cord-006229-7yoilsho	4029	8	member	member	NN
cord-006229-7yoilsho	4029	9	1	1	CD
cord-006229-7yoilsho	4029	10	(	(	-LRB-
cord-006229-7yoilsho	4029	11	ABCB1	ABCB1	NNP
cord-006229-7yoilsho	4029	12	)	)	-RRB-
cord-006229-7yoilsho	4029	13	is	be	VBZ
cord-006229-7yoilsho	4029	14	a	a	DT
cord-006229-7yoilsho	4029	15	drug	drug	NN
cord-006229-7yoilsho	4029	16	efflux	efflux	NN
cord-006229-7yoilsho	4029	17	pump	pump	NN
cord-006229-7yoilsho	4029	18	responsible	responsible	JJ
cord-006229-7yoilsho	4029	19	for	for	IN
cord-006229-7yoilsho	4029	20	the	the	DT
cord-006229-7yoilsho	4029	21	classic	classic	JJ
cord-006229-7yoilsho	4029	22	multi	multi	JJ
cord-006229-7yoilsho	4029	23	-	-	JJ
cord-006229-7yoilsho	4029	24	drug	drug	JJ
cord-006229-7yoilsho	4029	25	resistance	resistance	NN
cord-006229-7yoilsho	4029	26	phenotype	phenotype	NN
cord-006229-7yoilsho	4029	27	in	in	IN
cord-006229-7yoilsho	4029	28	cancer	cancer	NN
cord-006229-7yoilsho	4029	29	cells	cell	NNS
cord-006229-7yoilsho	4029	30	.	.	.
cord-006229-7yoilsho	4030	1	Increased	increase	VBN
cord-006229-7yoilsho	4030	2	activity	activity	NN
cord-006229-7yoilsho	4030	3	of	of	IN
cord-006229-7yoilsho	4030	4	ABCB1	abcb1	NN
cord-006229-7yoilsho	4030	5	in	in	IN
cord-006229-7yoilsho	4030	6	cancer	cancer	NN
cord-006229-7yoilsho	4030	7	cells	cell	NNS
cord-006229-7yoilsho	4030	8	contributes	contribute	VBZ
cord-006229-7yoilsho	4030	9	to	to	IN
cord-006229-7yoilsho	4030	10	protection	protection	NN
cord-006229-7yoilsho	4030	11	against	against	IN
cord-006229-7yoilsho	4030	12	a	a	DT
cord-006229-7yoilsho	4030	13	wide	wide	JJ
cord-006229-7yoilsho	4030	14	range	range	NN
cord-006229-7yoilsho	4030	15	of	of	IN
cord-006229-7yoilsho	4030	16	chemotherapeutic	chemotherapeutic	JJ
cord-006229-7yoilsho	4030	17	agents	agent	NNS
cord-006229-7yoilsho	4030	18	.	.	.
cord-006229-7yoilsho	4031	1	This	this	DT
cord-006229-7yoilsho	4031	2	dramatically	dramatically	RB
cord-006229-7yoilsho	4031	3	decreases	decrease	VBZ
cord-006229-7yoilsho	4031	4	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	4031	5	options	option	NNS
cord-006229-7yoilsho	4031	6	and	and	CC
cord-006229-7yoilsho	4031	7	the	the	DT
cord-006229-7yoilsho	4031	8	chance	chance	NN
cord-006229-7yoilsho	4031	9	of	of	IN
cord-006229-7yoilsho	4031	10	patient	patient	JJ
cord-006229-7yoilsho	4031	11	survival	survival	NN
cord-006229-7yoilsho	4031	12	.	.	.
cord-006229-7yoilsho	4032	1	Knowledge	knowledge	NN
cord-006229-7yoilsho	4032	2	of	of	IN
cord-006229-7yoilsho	4032	3	the	the	DT
cord-006229-7yoilsho	4032	4	underlying	underlie	VBG
cord-006229-7yoilsho	4032	5	mechanisms	mechanism	NNS
cord-006229-7yoilsho	4032	6	for	for	IN
cord-006229-7yoilsho	4032	7	ABCB1	abcb1	NN
cord-006229-7yoilsho	4032	8	deregulation	deregulation	NN
cord-006229-7yoilsho	4032	9	is	be	VBZ
cord-006229-7yoilsho	4032	10	a	a	DT
cord-006229-7yoilsho	4032	11	critical	critical	JJ
cord-006229-7yoilsho	4032	12	step	step	NN
cord-006229-7yoilsho	4032	13	for	for	IN
cord-006229-7yoilsho	4032	14	the	the	DT
cord-006229-7yoilsho	4032	15	reversal	reversal	NN
cord-006229-7yoilsho	4032	16	of	of	IN
cord-006229-7yoilsho	4032	17	this	this	DT
cord-006229-7yoilsho	4032	18	unfavorable	unfavorable	JJ
cord-006229-7yoilsho	4032	19	condition	condition	NN
cord-006229-7yoilsho	4032	20	.	.	.
cord-006229-7yoilsho	4033	1	Of	of	IN
cord-006229-7yoilsho	4033	2	note	note	VB
cord-006229-7yoilsho	4033	3	,	,	,
cord-006229-7yoilsho	4033	4	phosphatidylinositol-4,5-bisphosphate	phosphatidylinositol-4,5-bisphosphate	JJ
cord-006229-7yoilsho	4033	5	(	(	-LRB-
cord-006229-7yoilsho	4033	6	PIP	PIP	NNP
cord-006229-7yoilsho	4033	7	2	2	CD
cord-006229-7yoilsho	4033	8	)	)	-RRB-
cord-006229-7yoilsho	4033	9	is	be	VBZ
cord-006229-7yoilsho	4033	10	a	a	DT
cord-006229-7yoilsho	4033	11	known	know	VBN
cord-006229-7yoilsho	4033	12	regulator	regulator	NN
cord-006229-7yoilsho	4033	13	of	of	IN
cord-006229-7yoilsho	4033	14	ABCB1	ABCB1	NNP
cord-006229-7yoilsho	4033	15	.	.	.
cord-006229-7yoilsho	4034	1	The	the	DT
cord-006229-7yoilsho	4034	2	protein	protein	NN
cord-006229-7yoilsho	4034	3	"	"	``
cord-006229-7yoilsho	4034	4	Myristoylated	Myristoylated	NNP
cord-006229-7yoilsho	4034	5	Alanine	Alanine	NNP
cord-006229-7yoilsho	4034	6	-	-	HYPH
cord-006229-7yoilsho	4034	7	Rich	Rich	NNP
cord-006229-7yoilsho	4034	8	C	C	NNP
cord-006229-7yoilsho	4034	9	-	-	HYPH
cord-006229-7yoilsho	4034	10	Kinase	Kinase	NNP
cord-006229-7yoilsho	4034	11	Substrate	Substrate	NNP
cord-006229-7yoilsho	4034	12	"	"	''
cord-006229-7yoilsho	4034	13	(	(	-LRB-
cord-006229-7yoilsho	4034	14	MARCKS	MARCKS	NNP
cord-006229-7yoilsho	4034	15	)	)	-RRB-
cord-006229-7yoilsho	4034	16	is	be	VBZ
cord-006229-7yoilsho	4034	17	known	know	VBN
cord-006229-7yoilsho	4034	18	for	for	IN
cord-006229-7yoilsho	4034	19	its	-PRON-	PRP$
cord-006229-7yoilsho	4034	20	ability	ability	NN
cord-006229-7yoilsho	4034	21	to	to	TO
cord-006229-7yoilsho	4034	22	bind	bind	VB
cord-006229-7yoilsho	4034	23	and	and	CC
cord-006229-7yoilsho	4034	24	sequester	sequester	VB
cord-006229-7yoilsho	4034	25	the	the	DT
cord-006229-7yoilsho	4034	26	phospholipid	phospholipid	NN
cord-006229-7yoilsho	4034	27	PIP	PIP	NNP
cord-006229-7yoilsho	4034	28	2	2	CD
cord-006229-7yoilsho	4034	29	.	.	.
cord-006229-7yoilsho	4035	1	In	in	IN
cord-006229-7yoilsho	4035	2	various	various	JJ
cord-006229-7yoilsho	4035	3	forms	form	NNS
cord-006229-7yoilsho	4035	4	of	of	IN
cord-006229-7yoilsho	4035	5	colorectal	colorectal	JJ
cord-006229-7yoilsho	4035	6	cancer	cancer	NN
cord-006229-7yoilsho	4035	7	the	the	DT
cord-006229-7yoilsho	4035	8	deregulation	deregulation	NN
cord-006229-7yoilsho	4035	9	of	of	IN
cord-006229-7yoilsho	4035	10	MARCKS	MARCKS	NNP
cord-006229-7yoilsho	4035	11	protein	protein	NN
cord-006229-7yoilsho	4035	12	goes	go	VBZ
cord-006229-7yoilsho	4035	13	hand	hand	NN
cord-006229-7yoilsho	4035	14	in	in	IN
cord-006229-7yoilsho	4035	15	hand	hand	NN
cord-006229-7yoilsho	4035	16	with	with	IN
cord-006229-7yoilsho	4035	17	an	an	DT
cord-006229-7yoilsho	4035	18	increase	increase	NN
cord-006229-7yoilsho	4035	19	in	in	IN
cord-006229-7yoilsho	4035	20	malignancy	malignancy	NN
cord-006229-7yoilsho	4035	21	and	and	CC
cord-006229-7yoilsho	4035	22	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	4035	23	resistance	resistance	NN
cord-006229-7yoilsho	4035	24	.	.	.
cord-006229-7yoilsho	4036	1	In	in	IN
cord-006229-7yoilsho	4036	2	this	this	DT
cord-006229-7yoilsho	4036	3	study	study	NN
cord-006229-7yoilsho	4036	4	,	,	,
cord-006229-7yoilsho	4036	5	we	-PRON-	PRP
cord-006229-7yoilsho	4036	6	characterized	characterize	VBD
cord-006229-7yoilsho	4036	7	the	the	DT
cord-006229-7yoilsho	4036	8	enigmatic	enigmatic	JJ
cord-006229-7yoilsho	4036	9	MARCKS	marck	NNS
cord-006229-7yoilsho	4036	10	as	as	IN
cord-006229-7yoilsho	4036	11	a	a	DT
cord-006229-7yoilsho	4036	12	modulator	modulator	NN
cord-006229-7yoilsho	4036	13	of	of	IN
cord-006229-7yoilsho	4036	14	ABCB1	abcb1	NN
cord-006229-7yoilsho	4036	15	activity	activity	NN
cord-006229-7yoilsho	4036	16	.	.	.
cord-006229-7yoilsho	4037	1	We	-PRON-	PRP
cord-006229-7yoilsho	4037	2	focused	focus	VBD
cord-006229-7yoilsho	4037	3	on	on	IN
cord-006229-7yoilsho	4037	4	a	a	DT
cord-006229-7yoilsho	4037	5	subgroup	subgroup	NN
cord-006229-7yoilsho	4037	6	of	of	IN
cord-006229-7yoilsho	4037	7	colon	colon	NN
cord-006229-7yoilsho	4037	8	cancers	cancer	NNS
cord-006229-7yoilsho	4037	9	,	,	,
cord-006229-7yoilsho	4037	10	where	where	WRB
cord-006229-7yoilsho	4037	11	MARCKS	MARCKS	NNP
cord-006229-7yoilsho	4037	12	resides	reside	VBZ
cord-006229-7yoilsho	4037	13	in	in	IN
cord-006229-7yoilsho	4037	14	a	a	DT
cord-006229-7yoilsho	4037	15	hyperphosphorylated	hyperphosphorylate	VBN
cord-006229-7yoilsho	4037	16	state	state	NN
cord-006229-7yoilsho	4037	17	for	for	IN
cord-006229-7yoilsho	4037	18	which	which	WDT
cord-006229-7yoilsho	4037	19	the	the	DT
cord-006229-7yoilsho	4037	20	established	establish	VBN
cord-006229-7yoilsho	4037	21	cell	cell	NN
cord-006229-7yoilsho	4037	22	line	line	NN
cord-006229-7yoilsho	4037	23	HT-29	HT-29	NNP
cord-006229-7yoilsho	4037	24	served	serve	VBD
cord-006229-7yoilsho	4037	25	as	as	IN
cord-006229-7yoilsho	4037	26	a	a	DT
cord-006229-7yoilsho	4037	27	model	model	NN
cord-006229-7yoilsho	4037	28	.	.	.
cord-006229-7yoilsho	4038	1	We	-PRON-	PRP
cord-006229-7yoilsho	4038	2	employed	employ	VBD
cord-006229-7yoilsho	4038	3	various	various	JJ
cord-006229-7yoilsho	4038	4	in	in	IN
cord-006229-7yoilsho	4038	5	-	-	HYPH
cord-006229-7yoilsho	4038	6	vitro	vitro	FW
cord-006229-7yoilsho	4038	7	methods	method	NNS
cord-006229-7yoilsho	4038	8	for	for	IN
cord-006229-7yoilsho	4038	9	the	the	DT
cord-006229-7yoilsho	4038	10	measurement	measurement	NN
cord-006229-7yoilsho	4038	11	of	of	IN
cord-006229-7yoilsho	4038	12	ABCB1	ABCB1	NNP
cord-006229-7yoilsho	4038	13	activity	activity	NN
cord-006229-7yoilsho	4038	14	,	,	,
cord-006229-7yoilsho	4038	15	in	in	IN
cord-006229-7yoilsho	4038	16	combination	combination	NN
cord-006229-7yoilsho	4038	17	with	with	IN
cord-006229-7yoilsho	4038	18	imaging	image	VBG
cord-006229-7yoilsho	4038	19	experiments	experiment	NNS
cord-006229-7yoilsho	4038	20	,	,	,
cord-006229-7yoilsho	4038	21	assays	assay	NNS
cord-006229-7yoilsho	4038	22	for	for	IN
cord-006229-7yoilsho	4038	23	cellular	cellular	JJ
cord-006229-7yoilsho	4038	24	viability	viability	NN
cord-006229-7yoilsho	4038	25	and	and	CC
cord-006229-7yoilsho	4038	26	classical	classical	JJ
cord-006229-7yoilsho	4038	27	methods	method	NNS
cord-006229-7yoilsho	4038	28	of	of	IN
cord-006229-7yoilsho	4038	29	molecular	molecular	JJ
cord-006229-7yoilsho	4038	30	biology	biology	NN
cord-006229-7yoilsho	4038	31	.	.	.
cord-006229-7yoilsho	4039	1	We	-PRON-	PRP
cord-006229-7yoilsho	4039	2	combined	combine	VBD
cord-006229-7yoilsho	4039	3	these	these	DT
cord-006229-7yoilsho	4039	4	approaches	approach	NNS
cord-006229-7yoilsho	4039	5	with	with	IN
cord-006229-7yoilsho	4039	6	pharmacological	pharmacological	JJ
cord-006229-7yoilsho	4039	7	inhibition	inhibition	NN
cord-006229-7yoilsho	4039	8	of	of	IN
cord-006229-7yoilsho	4039	9	MARCKS	MARCKS	NNP
cord-006229-7yoilsho	4039	10	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	4039	11	state	state	NN
cord-006229-7yoilsho	4039	12	or	or	CC
cord-006229-7yoilsho	4039	13	RNAi	RNAi	NNS
cord-006229-7yoilsho	4039	14	-	-	HYPH
cord-006229-7yoilsho	4039	15	mediated	mediate	VBN
cord-006229-7yoilsho	4039	16	depletion	depletion	NN
cord-006229-7yoilsho	4039	17	of	of	IN
cord-006229-7yoilsho	4039	18	MARCKS	marck	NNS
cord-006229-7yoilsho	4039	19	.	.	.
cord-006229-7yoilsho	4040	1	With	with	IN
cord-006229-7yoilsho	4040	2	these	these	DT
cord-006229-7yoilsho	4040	3	interventions	intervention	NNS
cord-006229-7yoilsho	4040	4	we	-PRON-	PRP
cord-006229-7yoilsho	4040	5	could	could	MD
cord-006229-7yoilsho	4040	6	modulate	modulate	VB
cord-006229-7yoilsho	4040	7	endogenous	endogenous	JJ
cord-006229-7yoilsho	4040	8	ABCB1	ABCB1	NNP
cord-006229-7yoilsho	4040	9	activity	activity	NN
cord-006229-7yoilsho	4040	10	and	and	CC
cord-006229-7yoilsho	4040	11	re	re	NN
cord-006229-7yoilsho	4040	12	-	-	VB
cord-006229-7yoilsho	4040	13	sensitize	sensitize	VB
cord-006229-7yoilsho	4040	14	our	-PRON-	PRP$
cord-006229-7yoilsho	4040	15	cell	cell	NN
cord-006229-7yoilsho	4040	16	model	model	NN
cord-006229-7yoilsho	4040	17	against	against	IN
cord-006229-7yoilsho	4040	18	chemotherapeutic	chemotherapeutic	JJ
cord-006229-7yoilsho	4040	19	agents	agent	NNS
cord-006229-7yoilsho	4040	20	like	like	IN
cord-006229-7yoilsho	4040	21	5-fluorouracil	5-fluorouracil	CD
cord-006229-7yoilsho	4040	22	which	which	WDT
cord-006229-7yoilsho	4040	23	are	be	VBP
cord-006229-7yoilsho	4040	24	known	know	VBN
cord-006229-7yoilsho	4040	25	to	to	TO
cord-006229-7yoilsho	4040	26	be	be	VB
cord-006229-7yoilsho	4040	27	substrates	substrate	NNS
cord-006229-7yoilsho	4040	28	of	of	IN
cord-006229-7yoilsho	4040	29	ABCB1	ABCB1	NNP
cord-006229-7yoilsho	4040	30	.	.	.
cord-006229-7yoilsho	4041	1	Taken	take	VBN
cord-006229-7yoilsho	4041	2	together	together	RB
cord-006229-7yoilsho	4041	3	,	,	,
cord-006229-7yoilsho	4041	4	our	-PRON-	PRP$
cord-006229-7yoilsho	4041	5	findings	finding	NNS
cord-006229-7yoilsho	4041	6	suggest	suggest	VBP
cord-006229-7yoilsho	4041	7	a	a	DT
cord-006229-7yoilsho	4041	8	new	new	JJ
cord-006229-7yoilsho	4041	9	way	way	NN
cord-006229-7yoilsho	4041	10	how	how	WRB
cord-006229-7yoilsho	4041	11	a	a	DT
cord-006229-7yoilsho	4041	12	cancer	cancer	NN
cord-006229-7yoilsho	4041	13	cell	cell	NN
cord-006229-7yoilsho	4041	14	can	can	MD
cord-006229-7yoilsho	4041	15	gain	gain	VB
cord-006229-7yoilsho	4041	16	a	a	DT
cord-006229-7yoilsho	4041	17	state	state	NN
cord-006229-7yoilsho	4041	18	of	of	IN
cord-006229-7yoilsho	4041	19	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	4041	20	resistance	resistance	NN
cord-006229-7yoilsho	4041	21	.	.	.
cord-006229-7yoilsho	4042	1	The	the	DT
cord-006229-7yoilsho	4042	2	exploitation	exploitation	NN
cord-006229-7yoilsho	4042	3	of	of	IN
cord-006229-7yoilsho	4042	4	MARCKS	MARCKS	NNP
cord-006229-7yoilsho	4042	5	as	as	IN
cord-006229-7yoilsho	4042	6	modulator	modulator	NN
cord-006229-7yoilsho	4042	7	of	of	IN
cord-006229-7yoilsho	4042	8	ABCB1	abcb1	NN
cord-006229-7yoilsho	4042	9	might	may	MD
cord-006229-7yoilsho	4042	10	be	be	VB
cord-006229-7yoilsho	4042	11	a	a	DT
cord-006229-7yoilsho	4042	12	new	new	JJ
cord-006229-7yoilsho	4042	13	approach	approach	NN
cord-006229-7yoilsho	4042	14	to	to	TO
cord-006229-7yoilsho	4042	15	target	target	VB
cord-006229-7yoilsho	4042	16	resistant	resistant	JJ
cord-006229-7yoilsho	4042	17	tumors	tumor	NNS
cord-006229-7yoilsho	4042	18	without	without	IN
cord-006229-7yoilsho	4042	19	interfering	interfere	VBG
cord-006229-7yoilsho	4042	20	with	with	IN
cord-006229-7yoilsho	4042	21	the	the	DT
cord-006229-7yoilsho	4042	22	natural	natural	JJ
cord-006229-7yoilsho	4042	23	function	function	NN
cord-006229-7yoilsho	4042	24	of	of	IN
cord-006229-7yoilsho	4042	25	ABCB1	abcb1	NN
cord-006229-7yoilsho	4042	26	in	in	IN
cord-006229-7yoilsho	4042	27	non	non	JJ
cord-006229-7yoilsho	4042	28	-	-	JJ
cord-006229-7yoilsho	4042	29	malignant	malignant	JJ
cord-006229-7yoilsho	4042	30	tissue	tissue	NN
cord-006229-7yoilsho	4042	31	.	.	.
cord-006229-7yoilsho	4043	1	Background	background	NN
cord-006229-7yoilsho	4043	2	:	:	:
cord-006229-7yoilsho	4044	1	In	in	IN
cord-006229-7yoilsho	4044	2	several	several	JJ
cord-006229-7yoilsho	4044	3	large	large	JJ
cord-006229-7yoilsho	4044	4	clinical	clinical	JJ
cord-006229-7yoilsho	4044	5	studies	study	NNS
cord-006229-7yoilsho	4044	6	low	low	JJ
cord-006229-7yoilsho	4044	7	blood	blood	NN
cord-006229-7yoilsho	4044	8	concentrations	concentration	NNS
cord-006229-7yoilsho	4044	9	of	of	IN
cord-006229-7yoilsho	4044	10	homoarginine	homoarginine	NN
cord-006229-7yoilsho	4044	11	were	be	VBD
cord-006229-7yoilsho	4044	12	identified	identify	VBN
cord-006229-7yoilsho	4044	13	as	as	IN
cord-006229-7yoilsho	4044	14	independent	independent	JJ
cord-006229-7yoilsho	4044	15	risk	risk	NN
cord-006229-7yoilsho	4044	16	marker	marker	NN
cord-006229-7yoilsho	4044	17	for	for	IN
cord-006229-7yoilsho	4044	18	stroke	stroke	NN
cord-006229-7yoilsho	4044	19	,	,	,
cord-006229-7yoilsho	4044	20	cardiovascular	cardiovascular	JJ
cord-006229-7yoilsho	4044	21	events	event	NNS
cord-006229-7yoilsho	4044	22	and	and	CC
cord-006229-7yoilsho	4044	23	mortality	mortality	NN
cord-006229-7yoilsho	4044	24	.	.	.
cord-006229-7yoilsho	4045	1	Experimental	experimental	JJ
cord-006229-7yoilsho	4045	2	data	datum	NNS
cord-006229-7yoilsho	4045	3	suggest	suggest	VBP
cord-006229-7yoilsho	4045	4	an	an	DT
cord-006229-7yoilsho	4045	5	active	active	JJ
cord-006229-7yoilsho	4045	6	role	role	NN
cord-006229-7yoilsho	4045	7	of	of	IN
cord-006229-7yoilsho	4045	8	homoarginine	homoarginine	JJ
cord-006229-7yoilsho	4045	9	deficiency	deficiency	NN
cord-006229-7yoilsho	4045	10	in	in	IN
cord-006229-7yoilsho	4045	11	disease	disease	NN
cord-006229-7yoilsho	4045	12	development	development	NN
cord-006229-7yoilsho	4045	13	.	.	.
cord-006229-7yoilsho	4046	1	Interference	interference	NN
cord-006229-7yoilsho	4046	2	with	with	IN
cord-006229-7yoilsho	4046	3	L	l	NN
cord-006229-7yoilsho	4046	4	-	-	HYPH
cord-006229-7yoilsho	4046	5	arginine	arginine	NN
cord-006229-7yoilsho	4046	6	-	-	HYPH
cord-006229-7yoilsho	4046	7	dependent	dependent	JJ
cord-006229-7yoilsho	4046	8	pathways	pathway	NNS
cord-006229-7yoilsho	4046	9	and	and	CC
cord-006229-7yoilsho	4046	10	signaling	signaling	NN
cord-006229-7yoilsho	4046	11	has	have	VBZ
cord-006229-7yoilsho	4046	12	been	be	VBN
cord-006229-7yoilsho	4046	13	implicated	implicate	VBN
cord-006229-7yoilsho	4046	14	as	as	IN
cord-006229-7yoilsho	4046	15	a	a	DT
cord-006229-7yoilsho	4046	16	possible	possible	JJ
cord-006229-7yoilsho	4046	17	mechanism	mechanism	NN
cord-006229-7yoilsho	4046	18	.	.	.
cord-006229-7yoilsho	4047	1	It	-PRON-	PRP
cord-006229-7yoilsho	4047	2	was	be	VBD
cord-006229-7yoilsho	4047	3	the	the	DT
cord-006229-7yoilsho	4047	4	aim	aim	NN
cord-006229-7yoilsho	4047	5	of	of	IN
cord-006229-7yoilsho	4047	6	the	the	DT
cord-006229-7yoilsho	4047	7	present	present	JJ
cord-006229-7yoilsho	4047	8	study	study	NN
cord-006229-7yoilsho	4047	9	to	to	TO
cord-006229-7yoilsho	4047	10	identify	identify	VB
cord-006229-7yoilsho	4047	11	transport	transport	NN
cord-006229-7yoilsho	4047	12	mechanisms	mechanism	NNS
cord-006229-7yoilsho	4047	13	involved	involve	VBN
cord-006229-7yoilsho	4047	14	in	in	IN
cord-006229-7yoilsho	4047	15	the	the	DT
cord-006229-7yoilsho	4047	16	cellular	cellular	JJ
cord-006229-7yoilsho	4047	17	uptake	uptake	NN
cord-006229-7yoilsho	4047	18	and	and	CC
cord-006229-7yoilsho	4047	19	tissue	tissue	NN
cord-006229-7yoilsho	4047	20	distribution	distribution	NN
cord-006229-7yoilsho	4047	21	of	of	IN
cord-006229-7yoilsho	4047	22	homoarginine	homoarginine	NN
cord-006229-7yoilsho	4047	23	,	,	,
cord-006229-7yoilsho	4047	24	which	which	WDT
cord-006229-7yoilsho	4047	25	is	be	VBZ
cord-006229-7yoilsho	4047	26	poorly	poorly	RB
cord-006229-7yoilsho	4047	27	understood	understand	VBN
cord-006229-7yoilsho	4047	28	,	,	,
cord-006229-7yoilsho	4047	29	so	so	RB
cord-006229-7yoilsho	4047	30	far	far	RB
cord-006229-7yoilsho	4047	31	.	.	.
cord-006229-7yoilsho	4048	1	The	the	DT
cord-006229-7yoilsho	4048	2	experiments	experiment	NNS
cord-006229-7yoilsho	4048	3	focused	focus	VBD
cord-006229-7yoilsho	4048	4	on	on	IN
cord-006229-7yoilsho	4048	5	cationic	cationic	JJ
cord-006229-7yoilsho	4048	6	amino	amino	NN
cord-006229-7yoilsho	4048	7	acid	acid	NN
cord-006229-7yoilsho	4048	8	transporters	transporter	NNS
cord-006229-7yoilsho	4048	9	(	(	-LRB-
cord-006229-7yoilsho	4048	10	CATs	cat	NNS
cord-006229-7yoilsho	4048	11	)	)	-RRB-
cord-006229-7yoilsho	4048	12	and	and	CC
cord-006229-7yoilsho	4048	13	possible	possible	JJ
cord-006229-7yoilsho	4048	14	interactions	interaction	NNS
cord-006229-7yoilsho	4048	15	with	with	IN
cord-006229-7yoilsho	4048	16	known	know	VBN
cord-006229-7yoilsho	4048	17	CAT	cat	NN
cord-006229-7yoilsho	4048	18	substrates	substrate	NNS
cord-006229-7yoilsho	4048	19	.	.	.
cord-006229-7yoilsho	4049	1	Methods	method	NNS
cord-006229-7yoilsho	4049	2	:	:	:
cord-006229-7yoilsho	4049	3	Uptake	uptake	NN
cord-006229-7yoilsho	4049	4	assays	assay	NNS
cord-006229-7yoilsho	4049	5	were	be	VBD
cord-006229-7yoilsho	4049	6	performed	perform	VBN
cord-006229-7yoilsho	4049	7	using	use	VBG
cord-006229-7yoilsho	4049	8	[	[	-LRB-
cord-006229-7yoilsho	4049	9	3	3	CD
cord-006229-7yoilsho	4049	10	H]-labeled	H]-labeled	NNP
cord-006229-7yoilsho	4049	11	homoarginine	homoarginine	NN
cord-006229-7yoilsho	4049	12	as	as	IN
cord-006229-7yoilsho	4049	13	substrate	substrate	NN
cord-006229-7yoilsho	4049	14	and	and	CC
cord-006229-7yoilsho	4049	15	human	human	JJ
cord-006229-7yoilsho	4049	16	embryonic	embryonic	JJ
cord-006229-7yoilsho	4049	17	kidney	kidney	NN
cord-006229-7yoilsho	4049	18	(	(	-LRB-
cord-006229-7yoilsho	4049	19	HEK293	HEK293	NNP
cord-006229-7yoilsho	4049	20	)	)	-RRB-
cord-006229-7yoilsho	4049	21	cells	cell	NNS
cord-006229-7yoilsho	4049	22	stably	stably	RB
cord-006229-7yoilsho	4049	23	overexpressing	overexpresse	VBG
cord-006229-7yoilsho	4049	24	human	human	JJ
cord-006229-7yoilsho	4049	25	CAT1	CAT1	NNP
cord-006229-7yoilsho	4049	26	[	[	-LRB-
cord-006229-7yoilsho	4049	27	gene	gene	NN
cord-006229-7yoilsho	4049	28	:	:	:
cord-006229-7yoilsho	4049	29	SLC7A1	SLC7A1	NNP
cord-006229-7yoilsho	4049	30	(	(	-LRB-
cord-006229-7yoilsho	4049	31	solute	solute	NN
cord-006229-7yoilsho	4049	32	carrier	carrier	NN
cord-006229-7yoilsho	4049	33	family	family	NN
cord-006229-7yoilsho	4049	34	7	7	CD
cord-006229-7yoilsho	4049	35	)	)	-RRB-
cord-006229-7yoilsho	4049	36	]	]	-RRB-
cord-006229-7yoilsho	4049	37	,	,	,
cord-006229-7yoilsho	4049	38	CAT2A	CAT2A	NNP
cord-006229-7yoilsho	4049	39	(	(	-LRB-
cord-006229-7yoilsho	4049	40	SLC7A2A	slc7a2a	NN
cord-006229-7yoilsho	4049	41	)	)	-RRB-
cord-006229-7yoilsho	4049	42	or	or	CC
cord-006229-7yoilsho	4049	43	CAT2B	CAT2B	.
cord-006229-7yoilsho	4049	44	(	(	-LRB-
cord-006229-7yoilsho	4049	45	SLC7A2B	SLC7A2B	NNP
cord-006229-7yoilsho	4049	46	)	)	-RRB-
cord-006229-7yoilsho	4049	47	.	.	.
cord-006229-7yoilsho	4050	1	Cells	cell	NNS
cord-006229-7yoilsho	4050	2	transfected	transfecte	VBN
cord-006229-7yoilsho	4050	3	with	with	IN
cord-006229-7yoilsho	4050	4	an	an	DT
cord-006229-7yoilsho	4050	5	empty	empty	JJ
cord-006229-7yoilsho	4050	6	vector	vector	NN
cord-006229-7yoilsho	4050	7	were	be	VBD
cord-006229-7yoilsho	4050	8	used	use	VBN
cord-006229-7yoilsho	4050	9	as	as	IN
cord-006229-7yoilsho	4050	10	control	control	NN
cord-006229-7yoilsho	4050	11	.	.	.
cord-006229-7yoilsho	4051	1	Unlabeled	unlabeled	JJ
cord-006229-7yoilsho	4051	2	known	know	VBN
cord-006229-7yoilsho	4051	3	CATsubstrates	catsubstrate	NNS
cord-006229-7yoilsho	4051	4	L	l	NN
cord-006229-7yoilsho	4051	5	-	-	HYPH
cord-006229-7yoilsho	4051	6	arginine	arginine	NN
cord-006229-7yoilsho	4051	7	and	and	CC
cord-006229-7yoilsho	4051	8	asymmetric	asymmetric	JJ
cord-006229-7yoilsho	4051	9	dimethylarginine	dimethylarginine	NN
cord-006229-7yoilsho	4051	10	(	(	-LRB-
cord-006229-7yoilsho	4051	11	ADMA	ADMA	NNP
cord-006229-7yoilsho	4051	12	)	)	-RRB-
cord-006229-7yoilsho	4051	13	were	be	VBD
cord-006229-7yoilsho	4051	14	investigated	investigate	VBN
cord-006229-7yoilsho	4051	15	as	as	IN
cord-006229-7yoilsho	4051	16	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	4051	17	.	.	.
cord-006229-7yoilsho	4052	1	Results	result	NNS
cord-006229-7yoilsho	4052	2	:	:	:
cord-006229-7yoilsho	4053	1	Compared	compare	VBN
cord-006229-7yoilsho	4053	2	to	to	IN
cord-006229-7yoilsho	4053	3	the	the	DT
cord-006229-7yoilsho	4053	4	uptake	uptake	NN
cord-006229-7yoilsho	4053	5	into	into	IN
cord-006229-7yoilsho	4053	6	control	control	NN
cord-006229-7yoilsho	4053	7	cells	cell	NNS
cord-006229-7yoilsho	4053	8	,	,	,
cord-006229-7yoilsho	4053	9	uptake	uptake	NN
cord-006229-7yoilsho	4053	10	of	of	IN
cord-006229-7yoilsho	4053	11	homoarginine	homoarginine	NN
cord-006229-7yoilsho	4053	12	was	be	VBD
cord-006229-7yoilsho	4053	13	significantly	significantly	RB
cord-006229-7yoilsho	4053	14	higher	high	JJR
cord-006229-7yoilsho	4053	15	in	in	IN
cord-006229-7yoilsho	4053	16	HEK	HEK	NNP
cord-006229-7yoilsho	4053	17	cells	cell	NNS
cord-006229-7yoilsho	4053	18	overexpressing	overexpresse	VBG
cord-006229-7yoilsho	4053	19	CAT1	CAT1	NNP
cord-006229-7yoilsho	4053	20	(	(	-LRB-
cord-006229-7yoilsho	4053	21	7-fold	7-fold	CD
cord-006229-7yoilsho	4053	22	)	)	-RRB-
cord-006229-7yoilsho	4053	23	,	,	,
cord-006229-7yoilsho	4053	24	CAT2A	CAT2A	NNP
cord-006229-7yoilsho	4053	25	(	(	-LRB-
cord-006229-7yoilsho	4053	26	1.6-fold	1.6-fold	CD
cord-006229-7yoilsho	4053	27	)	)	-RRB-
cord-006229-7yoilsho	4053	28	or	or	CC
cord-006229-7yoilsho	4053	29	CAT2B	CAT2B	.
cord-006229-7yoilsho	4053	30	(	(	-LRB-
cord-006229-7yoilsho	4053	31	2.2-fold	2.2-fold	CD
cord-006229-7yoilsho	4053	32	)	)	-RRB-
cord-006229-7yoilsho	4053	33	after	after	IN
cord-006229-7yoilsho	4053	34	2.5	2.5	CD
cord-006229-7yoilsho	4053	35	min	min	NN
cord-006229-7yoilsho	4053	36	using	use	VBG
cord-006229-7yoilsho	4053	37	100	100	CD
cord-006229-7yoilsho	4053	38	µM	µm	NN
cord-006229-7yoilsho	4053	39	substrate	substrate	NN
cord-006229-7yoilsho	4053	40	(	(	-LRB-
cord-006229-7yoilsho	4053	41	each	each	DT
cord-006229-7yoilsho	4053	42	p<0.001	p<0.001	JJ
cord-006229-7yoilsho	4053	43	)	)	-RRB-
cord-006229-7yoilsho	4053	44	.	.	.
cord-006229-7yoilsho	4054	1	Apparent	apparent	JJ
cord-006229-7yoilsho	4054	2	K	K	NNP
cord-006229-7yoilsho	4054	3	m	m	NN
cord-006229-7yoilsho	4054	4	values	value	NNS
cord-006229-7yoilsho	4054	5	for	for	IN
cord-006229-7yoilsho	4054	6	cellular	cellular	JJ
cord-006229-7yoilsho	4054	7	net	net	JJ
cord-006229-7yoilsho	4054	8	uptake	uptake	NN
cord-006229-7yoilsho	4054	9	of	of	IN
cord-006229-7yoilsho	4054	10	homoarginine	homoarginine	NN
cord-006229-7yoilsho	4054	11	were	be	VBD
cord-006229-7yoilsho	4054	12	174.6	174.6	CD
cord-006229-7yoilsho	4054	13	µM	µM	VBG
cord-006229-7yoilsho	4054	14	for	for	IN
cord-006229-7yoilsho	4054	15	CAT1	CAT1	NNP
cord-006229-7yoilsho	4054	16	,	,	,
cord-006229-7yoilsho	4054	17	3640	3640	CD
cord-006229-7yoilsho	4054	18	µM	µm	NN
cord-006229-7yoilsho	4054	19	for	for	IN
cord-006229-7yoilsho	4054	20	CAT2A	cat2a	NN
cord-006229-7yoilsho	4054	21	and	and	CC
cord-006229-7yoilsho	4054	22	522.8	522.8	CD
cord-006229-7yoilsho	4054	23	µM	µM	VBG
cord-006229-7yoilsho	4054	24	for	for	IN
cord-006229-7yoilsho	4054	25	CAT2B.	cat2b.	NN
cord-006229-7yoilsho	4054	26	Homoarginine	homoarginine	JJ
cord-006229-7yoilsho	4054	27	uptake	uptake	NN
cord-006229-7yoilsho	4054	28	by	by	IN
cord-006229-7yoilsho	4054	29	the	the	DT
cord-006229-7yoilsho	4054	30	three	three	CD
cord-006229-7yoilsho	4054	31	CATs	cat	NNS
cord-006229-7yoilsho	4054	32	could	could	MD
cord-006229-7yoilsho	4054	33	be	be	VB
cord-006229-7yoilsho	4054	34	inhibited	inhibit	VBN
cord-006229-7yoilsho	4054	35	by	by	IN
cord-006229-7yoilsho	4054	36	addition	addition	NN
cord-006229-7yoilsho	4054	37	of	of	IN
cord-006229-7yoilsho	4054	38	L	l	NN
cord-006229-7yoilsho	4054	39	-	-	HYPH
cord-006229-7yoilsho	4054	40	arginine	arginine	NN
cord-006229-7yoilsho	4054	41	and	and	CC
cord-006229-7yoilsho	4054	42	ADMA	ADMA	NNP
cord-006229-7yoilsho	4054	43	.	.	.
cord-006229-7yoilsho	4055	1	Conclusion	conclusion	NN
cord-006229-7yoilsho	4055	2	:	:	:
cord-006229-7yoilsho	4056	1	The	the	DT
cord-006229-7yoilsho	4056	2	protective	protective	JJ
cord-006229-7yoilsho	4056	3	biomarker	biomarker	NN
cord-006229-7yoilsho	4056	4	homoarginine	homoarginine	NN
cord-006229-7yoilsho	4056	5	is	be	VBZ
cord-006229-7yoilsho	4056	6	a	a	DT
cord-006229-7yoilsho	4056	7	substrate	substrate	NN
cord-006229-7yoilsho	4056	8	of	of	IN
cord-006229-7yoilsho	4056	9	the	the	DT
cord-006229-7yoilsho	4056	10	human	human	JJ
cord-006229-7yoilsho	4056	11	cationic	cationic	JJ
cord-006229-7yoilsho	4056	12	amino	amino	NN
cord-006229-7yoilsho	4056	13	acid	acid	NN
cord-006229-7yoilsho	4056	14	transporters	transporter	NNS
cord-006229-7yoilsho	4056	15	CAT1	CAT1	NNP
cord-006229-7yoilsho	4056	16	,	,	,
cord-006229-7yoilsho	4056	17	CAT2A	cat2a	NN
cord-006229-7yoilsho	4056	18	and	and	CC
cord-006229-7yoilsho	4056	19	CAT2B.	cat2b.	NN
cord-006229-7yoilsho	4057	1	Compared	compare	VBN
cord-006229-7yoilsho	4057	2	to	to	IN
cord-006229-7yoilsho	4057	3	other	other	JJ
cord-006229-7yoilsho	4057	4	CAT	cat	NN
cord-006229-7yoilsho	4057	5	substrates	substrate	NNS
cord-006229-7yoilsho	4057	6	,	,	,
cord-006229-7yoilsho	4057	7	the	the	DT
cord-006229-7yoilsho	4057	8	CAT1-and	CAT1-and	NNP
cord-006229-7yoilsho	4057	9	CAT2B	cat2b	NN
cord-006229-7yoilsho	4057	10	-	-	HYPH
cord-006229-7yoilsho	4057	11	mediated	mediate	VBN
cord-006229-7yoilsho	4057	12	homoarginine	homoarginine	NN
cord-006229-7yoilsho	4057	13	transport	transport	NN
cord-006229-7yoilsho	4057	14	is	be	VBZ
cord-006229-7yoilsho	4057	15	characterized	characterize	VBN
cord-006229-7yoilsho	4057	16	by	by	IN
cord-006229-7yoilsho	4057	17	relatively	relatively	RB
cord-006229-7yoilsho	4057	18	high	high	JJ
cord-006229-7yoilsho	4057	19	affinity	affinity	NN
cord-006229-7yoilsho	4057	20	.	.	.
cord-006229-7yoilsho	4058	1	The	the	DT
cord-006229-7yoilsho	4058	2	uptake	uptake	NN
cord-006229-7yoilsho	4058	3	of	of	IN
cord-006229-7yoilsho	4058	4	homoarginine	homoarginine	NN
cord-006229-7yoilsho	4058	5	by	by	IN
cord-006229-7yoilsho	4058	6	all	all	DT
cord-006229-7yoilsho	4058	7	three	three	CD
cord-006229-7yoilsho	4058	8	CATs	cat	NNS
cord-006229-7yoilsho	4058	9	can	can	MD
cord-006229-7yoilsho	4058	10	be	be	VB
cord-006229-7yoilsho	4058	11	inhibited	inhibit	VBN
cord-006229-7yoilsho	4058	12	by	by	IN
cord-006229-7yoilsho	4058	13	L	l	NN
cord-006229-7yoilsho	4058	14	-	-	HYPH
cord-006229-7yoilsho	4058	15	arginine	arginine	NN
cord-006229-7yoilsho	4058	16	and	and	CC
cord-006229-7yoilsho	4058	17	ADMA	ADMA	NNP
cord-006229-7yoilsho	4058	18	.	.	.
cord-006229-7yoilsho	4059	1	Taken	take	VBN
cord-006229-7yoilsho	4059	2	together	together	RB
cord-006229-7yoilsho	4059	3	these	these	DT
cord-006229-7yoilsho	4059	4	findings	finding	NNS
cord-006229-7yoilsho	4059	5	make	make	VBP
cord-006229-7yoilsho	4059	6	CAT	cat	NN
cord-006229-7yoilsho	4059	7	-	-	HYPH
cord-006229-7yoilsho	4059	8	mediated	mediate	VBN
cord-006229-7yoilsho	4059	9	transport	transport	NN
cord-006229-7yoilsho	4059	10	of	of	IN
cord-006229-7yoilsho	4059	11	homoarginine	homoarginine	NN
cord-006229-7yoilsho	4059	12	a	a	DT
cord-006229-7yoilsho	4059	13	possible	possible	JJ
cord-006229-7yoilsho	4059	14	target	target	NN
cord-006229-7yoilsho	4059	15	for	for	IN
cord-006229-7yoilsho	4059	16	interactions	interaction	NNS
cord-006229-7yoilsho	4059	17	and	and	CC
cord-006229-7yoilsho	4059	18	pharmacological	pharmacological	JJ
cord-006229-7yoilsho	4059	19	interventions	intervention	NNS
cord-006229-7yoilsho	4059	20	aimed	aim	VBN
cord-006229-7yoilsho	4059	21	at	at	IN
cord-006229-7yoilsho	4059	22	homoarginine	homoarginine	NN
cord-006229-7yoilsho	4059	23	homeostasis	homeostasis	NN
cord-006229-7yoilsho	4059	24	.	.	.
cord-006229-7yoilsho	4060	1	This	this	DT
cord-006229-7yoilsho	4060	2	project	project	NN
cord-006229-7yoilsho	4060	3	is	be	VBZ
cord-006229-7yoilsho	4060	4	supported	support	VBN
cord-006229-7yoilsho	4060	5	by	by	IN
cord-006229-7yoilsho	4060	6	the	the	DT
cord-006229-7yoilsho	4060	7	DOKTOR	DOKTOR	NNP
cord-006229-7yoilsho	4060	8	ROBERT	ROBERT	NNP
cord-006229-7yoilsho	4060	9	PFLEGER	PFLEGER	NNP
cord-006229-7yoilsho	4060	10	-	-	HYPH
cord-006229-7yoilsho	4060	11	STIFTUNG	STIFTUNG	NNP
cord-006229-7yoilsho	4060	12	.	.	.
cord-006229-7yoilsho	4060	13	 	 	_SP
cord-006229-7yoilsho	4061	1	Background	background	NN
cord-006229-7yoilsho	4061	2	and	and	CC
cord-006229-7yoilsho	4061	3	aim	aim	VB
cord-006229-7yoilsho	4062	1	:	:	:
cord-006229-7yoilsho	4062	2	Organic	organic	JJ
cord-006229-7yoilsho	4062	3	cation	cation	NN
cord-006229-7yoilsho	4062	4	transporter	transporter	NN
cord-006229-7yoilsho	4062	5	1	1	CD
cord-006229-7yoilsho	4062	6	(	(	-LRB-
cord-006229-7yoilsho	4062	7	OCT1	OCT1	NNP
cord-006229-7yoilsho	4062	8	,	,	,
cord-006229-7yoilsho	4062	9	alternative	alternative	JJ
cord-006229-7yoilsho	4062	10	name	name	NN
cord-006229-7yoilsho	4062	11	SLCC22A1	SLCC22A1	NNP
cord-006229-7yoilsho	4062	12	)	)	-RRB-
cord-006229-7yoilsho	4062	13	is	be	VBZ
cord-006229-7yoilsho	4062	14	a	a	DT
cord-006229-7yoilsho	4062	15	polyspecific	polyspecific	JJ
cord-006229-7yoilsho	4062	16	membrane	membrane	NN
cord-006229-7yoilsho	4062	17	transporter	transporter	NN
cord-006229-7yoilsho	4062	18	,	,	,
cord-006229-7yoilsho	4062	19	which	which	WDT
cord-006229-7yoilsho	4062	20	has	have	VBZ
cord-006229-7yoilsho	4062	21	been	be	VBN
cord-006229-7yoilsho	4062	22	suggested	suggest	VBN
cord-006229-7yoilsho	4062	23	to	to	TO
cord-006229-7yoilsho	4062	24	play	play	VB
cord-006229-7yoilsho	4062	25	a	a	DT
cord-006229-7yoilsho	4062	26	role	role	NN
cord-006229-7yoilsho	4062	27	in	in	IN
cord-006229-7yoilsho	4062	28	absorption	absorption	NN
cord-006229-7yoilsho	4062	29	,	,	,
cord-006229-7yoilsho	4062	30	distribution	distribution	NN
cord-006229-7yoilsho	4062	31	and	and	CC
cord-006229-7yoilsho	4062	32	elimination	elimination	NN
cord-006229-7yoilsho	4062	33	of	of	IN
cord-006229-7yoilsho	4062	34	drugs	drug	NNS
cord-006229-7yoilsho	4062	35	and	and	CC
cord-006229-7yoilsho	4062	36	toxins	toxin	NNS
cord-006229-7yoilsho	4062	37	.	.	.
cord-006229-7yoilsho	4063	1	Besides	besides	IN
cord-006229-7yoilsho	4063	2	endogenous	endogenous	JJ
cord-006229-7yoilsho	4063	3	compounds	compound	NNS
cord-006229-7yoilsho	4063	4	like	like	IN
cord-006229-7yoilsho	4063	5	thiamine	thiamine	NN
cord-006229-7yoilsho	4063	6	(	(	-LRB-
cord-006229-7yoilsho	4063	7	vitamin	vitamin	NN
cord-006229-7yoilsho	4063	8	B1	b1	NN
cord-006229-7yoilsho	4063	9	)	)	-RRB-
cord-006229-7yoilsho	4063	10	,	,	,
cord-006229-7yoilsho	4063	11	known	know	VBN
cord-006229-7yoilsho	4063	12	OCT1	OCT1	NNP
cord-006229-7yoilsho	4063	13	substrates	substrate	NNS
cord-006229-7yoilsho	4063	14	are	be	VBP
cord-006229-7yoilsho	4063	15	toxins	toxin	NNS
cord-006229-7yoilsho	4063	16	like	like	IN
cord-006229-7yoilsho	4063	17	MPP	MPP	NNP
cord-006229-7yoilsho	4063	18	+	+	CC
cord-006229-7yoilsho	4063	19	as	as	RB
cord-006229-7yoilsho	4063	20	well	well	RB
cord-006229-7yoilsho	4063	21	as	as	IN
cord-006229-7yoilsho	4063	22	drugs	drug	NNS
cord-006229-7yoilsho	4063	23	like	like	IN
cord-006229-7yoilsho	4063	24	metformin	metformin	NNP
cord-006229-7yoilsho	4063	25	,	,	,
cord-006229-7yoilsho	4063	26	O	o	NN
cord-006229-7yoilsho	4063	27	-	-	HYPH
cord-006229-7yoilsho	4063	28	desmethyltramadol	desmethyltramadol	NN
cord-006229-7yoilsho	4063	29	,	,	,
cord-006229-7yoilsho	4063	30	ranitidine	ranitidine	NN
cord-006229-7yoilsho	4063	31	,	,	,
cord-006229-7yoilsho	4063	32	and	and	CC
cord-006229-7yoilsho	4063	33	sumatriptan	sumatriptan	NNP
cord-006229-7yoilsho	4063	34	.	.	.
cord-006229-7yoilsho	4064	1	Tissue	tissue	NN
cord-006229-7yoilsho	4064	2	distribution	distribution	NN
cord-006229-7yoilsho	4064	3	of	of	IN
cord-006229-7yoilsho	4064	4	OCT1	OCT1	NNP
cord-006229-7yoilsho	4064	5	has	have	VBZ
cord-006229-7yoilsho	4064	6	been	be	VBN
cord-006229-7yoilsho	4064	7	shown	show	VBN
cord-006229-7yoilsho	4064	8	to	to	TO
cord-006229-7yoilsho	4064	9	have	have	VB
cord-006229-7yoilsho	4064	10	strong	strong	JJ
cord-006229-7yoilsho	4064	11	inter	inter	JJ
cord-006229-7yoilsho	4064	12	-	-	JJ
cord-006229-7yoilsho	4064	13	species	species	JJ
cord-006229-7yoilsho	4064	14	differences	difference	NNS
cord-006229-7yoilsho	4064	15	.	.	.
cord-006229-7yoilsho	4065	1	In	in	IN
cord-006229-7yoilsho	4065	2	rodents	rodent	NNS
cord-006229-7yoilsho	4065	3	Oct1	Oct1	NNP
cord-006229-7yoilsho	4065	4	is	be	VBZ
cord-006229-7yoilsho	4065	5	strongly	strongly	RB
cord-006229-7yoilsho	4065	6	expressed	express	VBN
cord-006229-7yoilsho	4065	7	in	in	IN
cord-006229-7yoilsho	4065	8	both	both	CC
cord-006229-7yoilsho	4065	9	the	the	DT
cord-006229-7yoilsho	4065	10	sinusoidal	sinusoidal	JJ
cord-006229-7yoilsho	4065	11	membrane	membrane	NN
cord-006229-7yoilsho	4065	12	of	of	IN
cord-006229-7yoilsho	4065	13	hepatocytes	hepatocyte	NNS
cord-006229-7yoilsho	4065	14	and	and	CC
cord-006229-7yoilsho	4065	15	the	the	DT
cord-006229-7yoilsho	4065	16	basolateral	basolateral	JJ
cord-006229-7yoilsho	4065	17	membrane	membrane	NN
cord-006229-7yoilsho	4065	18	of	of	IN
cord-006229-7yoilsho	4065	19	kidney	kidney	NN
cord-006229-7yoilsho	4065	20	epithelial	epithelial	JJ
cord-006229-7yoilsho	4065	21	cells	cell	NNS
cord-006229-7yoilsho	4065	22	.	.	.
cord-006229-7yoilsho	4066	1	Human	Human	NNP
cord-006229-7yoilsho	4066	2	OCT1	OCT1	NNP
cord-006229-7yoilsho	4066	3	is	be	VBZ
cord-006229-7yoilsho	4066	4	strongly	strongly	RB
cord-006229-7yoilsho	4066	5	expressed	express	VBN
cord-006229-7yoilsho	4066	6	on	on	IN
cord-006229-7yoilsho	4066	7	the	the	DT
cord-006229-7yoilsho	4066	8	sinusoidal	sinusoidal	JJ
cord-006229-7yoilsho	4066	9	membrane	membrane	NN
cord-006229-7yoilsho	4066	10	of	of	IN
cord-006229-7yoilsho	4066	11	hepatocytes	hepatocyte	NNS
cord-006229-7yoilsho	4066	12	,	,	,
cord-006229-7yoilsho	4066	13	but	but	CC
cord-006229-7yoilsho	4066	14	not	not	RB
cord-006229-7yoilsho	4066	15	in	in	IN
cord-006229-7yoilsho	4066	16	the	the	DT
cord-006229-7yoilsho	4066	17	kidney	kidney	NN
cord-006229-7yoilsho	4066	18	.	.	.
cord-006229-7yoilsho	4067	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	4067	2	,	,	,
cord-006229-7yoilsho	4067	3	substrate	substrate	JJ
cord-006229-7yoilsho	4067	4	specific	specific	JJ
cord-006229-7yoilsho	4067	5	differences	difference	NNS
cord-006229-7yoilsho	4067	6	have	have	VBP
cord-006229-7yoilsho	4067	7	been	be	VBN
cord-006229-7yoilsho	4067	8	observed	observe	VBN
cord-006229-7yoilsho	4067	9	between	between	IN
cord-006229-7yoilsho	4067	10	the	the	DT
cord-006229-7yoilsho	4067	11	human	human	JJ
cord-006229-7yoilsho	4067	12	and	and	CC
cord-006229-7yoilsho	4067	13	rodent	rodent	NN
cord-006229-7yoilsho	4067	14	OCT1	OCT1	NNP
cord-006229-7yoilsho	4067	15	orthologs	ortholog	NNS
cord-006229-7yoilsho	4067	16	.	.	.
cord-006229-7yoilsho	4068	1	The	the	DT
cord-006229-7yoilsho	4068	2	aim	aim	NN
cord-006229-7yoilsho	4068	3	of	of	IN
cord-006229-7yoilsho	4068	4	this	this	DT
cord-006229-7yoilsho	4068	5	study	study	NN
cord-006229-7yoilsho	4068	6	is	be	VBZ
cord-006229-7yoilsho	4068	7	to	to	TO
cord-006229-7yoilsho	4068	8	characterize	characterize	VB
cord-006229-7yoilsho	4068	9	the	the	DT
cord-006229-7yoilsho	4068	10	mechanisms	mechanism	NNS
cord-006229-7yoilsho	4068	11	causing	cause	VBG
cord-006229-7yoilsho	4068	12	substrate	substrate	JJ
cord-006229-7yoilsho	4068	13	specificity	specificity	NN
cord-006229-7yoilsho	4068	14	between	between	IN
cord-006229-7yoilsho	4068	15	rodent	rodent	NN
cord-006229-7yoilsho	4068	16	and	and	CC
cord-006229-7yoilsho	4068	17	human	human	JJ
cord-006229-7yoilsho	4068	18	OCT1	OCT1	NNP
cord-006229-7yoilsho	4068	19	orthologs	ortholog	NNS
cord-006229-7yoilsho	4068	20	.	.	.
cord-006229-7yoilsho	4069	1	Methods	method	NNS
cord-006229-7yoilsho	4069	2	:	:	:
cord-006229-7yoilsho	4069	3	Overexpression	Overexpression	NNP
cord-006229-7yoilsho	4069	4	of	of	IN
cord-006229-7yoilsho	4069	5	OCT1	OCT1	NNP
cord-006229-7yoilsho	4069	6	orthologs	ortholog	NNS
cord-006229-7yoilsho	4069	7	in	in	IN
cord-006229-7yoilsho	4069	8	mouse	mouse	NN
cord-006229-7yoilsho	4069	9	,	,	,
cord-006229-7yoilsho	4069	10	rat	rat	NN
cord-006229-7yoilsho	4069	11	and	and	CC
cord-006229-7yoilsho	4069	12	human	human	JJ
cord-006229-7yoilsho	4069	13	cells	cell	NNS
cord-006229-7yoilsho	4069	14	was	be	VBD
cord-006229-7yoilsho	4069	15	performed	perform	VBN
cord-006229-7yoilsho	4069	16	by	by	IN
cord-006229-7yoilsho	4069	17	targeted	target	VBN
cord-006229-7yoilsho	4069	18	chromosomal	chromosomal	JJ
cord-006229-7yoilsho	4069	19	integration	integration	NN
cord-006229-7yoilsho	4069	20	of	of	IN
cord-006229-7yoilsho	4069	21	T	T	NNP
cord-006229-7yoilsho	4069	22	-	-	HYPH
cord-006229-7yoilsho	4069	23	REx	REx	NNP
cord-006229-7yoilsho	4069	24	™	™	CD
cord-006229-7yoilsho	4069	25	293	293	CD
cord-006229-7yoilsho	4069	26	.	.	.
cord-006229-7yoilsho	4070	1	The	the	DT
cord-006229-7yoilsho	4070	2	cells	cell	NNS
cord-006229-7yoilsho	4070	3	were	be	VBD
cord-006229-7yoilsho	4070	4	characterized	characterize	VBN
cord-006229-7yoilsho	4070	5	in	in	IN
cord-006229-7yoilsho	4070	6	detail	detail	NN
cord-006229-7yoilsho	4070	7	for	for	IN
cord-006229-7yoilsho	4070	8	their	-PRON-	PRP$
cord-006229-7yoilsho	4070	9	ability	ability	NN
cord-006229-7yoilsho	4070	10	to	to	TO
cord-006229-7yoilsho	4070	11	transport	transport	VB
cord-006229-7yoilsho	4070	12	the	the	DT
cord-006229-7yoilsho	4070	13	model	model	NN
cord-006229-7yoilsho	4070	14	substrates	substrate	NNS
cord-006229-7yoilsho	4070	15	TEA	tea	NN
cord-006229-7yoilsho	4070	16	+	+	CC
cord-006229-7yoilsho	4070	17	,	,	,
cord-006229-7yoilsho	4070	18	MPP	MPP	NNP
cord-006229-7yoilsho	4070	19	+	+	SYM
cord-006229-7yoilsho	4070	20	,	,	,
cord-006229-7yoilsho	4070	21	and	and	CC
cord-006229-7yoilsho	4070	22	ASP	ASP	NNP
cord-006229-7yoilsho	4070	23	+	+	CC
cord-006229-7yoilsho	4070	24	,	,	,
cord-006229-7yoilsho	4070	25	the	the	DT
cord-006229-7yoilsho	4070	26	drugs	drug	NNS
cord-006229-7yoilsho	4070	27	ranitidine	ranitidine	NN
cord-006229-7yoilsho	4070	28	,	,	,
cord-006229-7yoilsho	4070	29	sumatriptan	sumatriptan	NNP
cord-006229-7yoilsho	4070	30	and	and	CC
cord-006229-7yoilsho	4070	31	fenoterol	fenoterol	NNP
cord-006229-7yoilsho	4070	32	.	.	.
cord-006229-7yoilsho	4071	1	Results	result	NNS
cord-006229-7yoilsho	4071	2	:	:	:
cord-006229-7yoilsho	4072	1	Mouse	mouse	NN
cord-006229-7yoilsho	4072	2	and	and	CC
cord-006229-7yoilsho	4072	3	rat	rat	NN
cord-006229-7yoilsho	4072	4	Oct1	Oct1	NNP
cord-006229-7yoilsho	4072	5	orthologs	ortholog	NNS
cord-006229-7yoilsho	4072	6	showed	show	VBD
cord-006229-7yoilsho	4072	7	similar	similar	JJ
cord-006229-7yoilsho	4072	8	transport	transport	NN
cord-006229-7yoilsho	4072	9	activity	activity	NN
cord-006229-7yoilsho	4072	10	for	for	IN
cord-006229-7yoilsho	4072	11	all	all	PDT
cord-006229-7yoilsho	4072	12	the	the	DT
cord-006229-7yoilsho	4072	13	model	model	NN
cord-006229-7yoilsho	4072	14	substrates	substrate	NNS
cord-006229-7yoilsho	4072	15	and	and	CC
cord-006229-7yoilsho	4072	16	drugs	drug	NNS
cord-006229-7yoilsho	4072	17	tested	test	VBN
cord-006229-7yoilsho	4072	18	.	.	.
cord-006229-7yoilsho	4073	1	However	however	RB
cord-006229-7yoilsho	4073	2	,	,	,
cord-006229-7yoilsho	4073	3	significant	significant	JJ
cord-006229-7yoilsho	4073	4	differences	difference	NNS
cord-006229-7yoilsho	4073	5	were	be	VBD
cord-006229-7yoilsho	4073	6	observed	observe	VBN
cord-006229-7yoilsho	4073	7	when	when	WRB
cord-006229-7yoilsho	4073	8	rodent	rodent	NN
cord-006229-7yoilsho	4073	9	orthologs	ortholog	NNS
cord-006229-7yoilsho	4073	10	were	be	VBD
cord-006229-7yoilsho	4073	11	compared	compare	VBN
cord-006229-7yoilsho	4073	12	to	to	IN
cord-006229-7yoilsho	4073	13	the	the	DT
cord-006229-7yoilsho	4073	14	human	human	JJ
cord-006229-7yoilsho	4073	15	OCT1	OCT1	NNP
cord-006229-7yoilsho	4073	16	.	.	.
cord-006229-7yoilsho	4074	1	Human	Human	NNP
cord-006229-7yoilsho	4074	2	OCT1	OCT1	NNP
cord-006229-7yoilsho	4074	3	showed	show	VBD
cord-006229-7yoilsho	4074	4	a	a	DT
cord-006229-7yoilsho	4074	5	5fold	5fold	CD
cord-006229-7yoilsho	4074	6	higher	high	JJR
cord-006229-7yoilsho	4074	7	v	v	NN
cord-006229-7yoilsho	4074	8	max	max	NN
cord-006229-7yoilsho	4074	9	for	for	IN
cord-006229-7yoilsho	4074	10	the	the	DT
cord-006229-7yoilsho	4074	11	uptake	uptake	NN
cord-006229-7yoilsho	4074	12	of	of	IN
cord-006229-7yoilsho	4074	13	ASP	ASP	NNP
cord-006229-7yoilsho	4074	14	+	+	CC
cord-006229-7yoilsho	4074	15	and	and	CC
cord-006229-7yoilsho	4074	16	2-fold	2-fold	JJ
cord-006229-7yoilsho	4074	17	increase	increase	NN
cord-006229-7yoilsho	4074	18	of	of	IN
cord-006229-7yoilsho	4074	19	v	v	CD
cord-006229-7yoilsho	4074	20	max	max	NN
cord-006229-7yoilsho	4074	21	for	for	IN
cord-006229-7yoilsho	4074	22	sumatriptan	sumatriptan	NNP
cord-006229-7yoilsho	4074	23	in	in	IN
cord-006229-7yoilsho	4074	24	comparison	comparison	NN
cord-006229-7yoilsho	4074	25	to	to	IN
cord-006229-7yoilsho	4074	26	the	the	DT
cord-006229-7yoilsho	4074	27	rodent	rodent	NN
cord-006229-7yoilsho	4074	28	OCT1	OCT1	NNP
cord-006229-7yoilsho	4074	29	orthologs	ortholog	NNS
cord-006229-7yoilsho	4074	30	.	.	.
cord-006229-7yoilsho	4075	1	Conversely	conversely	RB
cord-006229-7yoilsho	4075	2	,	,	,
cord-006229-7yoilsho	4075	3	human	human	JJ
cord-006229-7yoilsho	4075	4	OCT1	OCT1	NNP
cord-006229-7yoilsho	4075	5	showed	show	VBD
cord-006229-7yoilsho	4075	6	a	a	DT
cord-006229-7yoilsho	4075	7	4-fold	4-fold	CD
cord-006229-7yoilsho	4075	8	lower	low	JJR
cord-006229-7yoilsho	4075	9	v	v	NN
cord-006229-7yoilsho	4075	10	max	max	NN
cord-006229-7yoilsho	4075	11	for	for	IN
cord-006229-7yoilsho	4075	12	the	the	DT
cord-006229-7yoilsho	4075	13	uptake	uptake	NN
cord-006229-7yoilsho	4075	14	of	of	IN
cord-006229-7yoilsho	4075	15	fenoterol	fenoterol	NNP
cord-006229-7yoilsho	4075	16	compared	compare	VBN
cord-006229-7yoilsho	4075	17	to	to	IN
cord-006229-7yoilsho	4075	18	rodent	rodent	NN
cord-006229-7yoilsho	4075	19	Oct1s	oct1s	NN
cord-006229-7yoilsho	4075	20	.	.	.
cord-006229-7yoilsho	4076	1	There	there	EX
cord-006229-7yoilsho	4076	2	was	be	VBD
cord-006229-7yoilsho	4076	3	no	no	DT
cord-006229-7yoilsho	4076	4	difference	difference	NN
cord-006229-7yoilsho	4076	5	between	between	IN
cord-006229-7yoilsho	4076	6	rodent	rodent	NN
cord-006229-7yoilsho	4076	7	and	and	CC
cord-006229-7yoilsho	4076	8	human	human	JJ
cord-006229-7yoilsho	4076	9	OCT1	OCT1	NNP
cord-006229-7yoilsho	4076	10	in	in	IN
cord-006229-7yoilsho	4076	11	the	the	DT
cord-006229-7yoilsho	4076	12	uptake	uptake	NN
cord-006229-7yoilsho	4076	13	of	of	IN
cord-006229-7yoilsho	4076	14	ranitidine	ranitidine	NN
cord-006229-7yoilsho	4076	15	.	.	.
cord-006229-7yoilsho	4077	1	These	these	DT
cord-006229-7yoilsho	4077	2	differences	difference	NNS
cord-006229-7yoilsho	4077	3	were	be	VBD
cord-006229-7yoilsho	4077	4	further	further	RB
cord-006229-7yoilsho	4077	5	characterized	characterize	VBN
cord-006229-7yoilsho	4077	6	in	in	IN
cord-006229-7yoilsho	4077	7	detail	detail	NN
cord-006229-7yoilsho	4077	8	using	use	VBG
cord-006229-7yoilsho	4077	9	chimeric	chimeric	JJ
cord-006229-7yoilsho	4077	10	mouse	mouse	NN
cord-006229-7yoilsho	4077	11	-	-	HYPH
cord-006229-7yoilsho	4077	12	human	human	JJ
cord-006229-7yoilsho	4077	13	OCT1	OCT1	NNP
cord-006229-7yoilsho	4077	14	constructs	construct	NNS
cord-006229-7yoilsho	4077	15	and	and	CC
cord-006229-7yoilsho	4077	16	by	by	IN
cord-006229-7yoilsho	4077	17	comparing	compare	VBG
cord-006229-7yoilsho	4077	18	the	the	DT
cord-006229-7yoilsho	4077	19	effects	effect	NNS
cord-006229-7yoilsho	4077	20	of	of	IN
cord-006229-7yoilsho	4077	21	key	key	JJ
cord-006229-7yoilsho	4077	22	point	point	NN
cord-006229-7yoilsho	4077	23	mutations	mutation	NNS
cord-006229-7yoilsho	4077	24	in	in	IN
cord-006229-7yoilsho	4077	25	mouse	mouse	NN
cord-006229-7yoilsho	4077	26	and	and	CC
cord-006229-7yoilsho	4077	27	human	human	NN
cord-006229-7yoilsho	4077	28	OCT1	OCT1	NNP
cord-006229-7yoilsho	4077	29	orthologs	ortholog	NNS
cord-006229-7yoilsho	4077	30	.	.	.
cord-006229-7yoilsho	4078	1	Conclusions	conclusion	NNS
cord-006229-7yoilsho	4078	2	:	:	:
cord-006229-7yoilsho	4079	1	These	these	DT
cord-006229-7yoilsho	4079	2	data	datum	NNS
cord-006229-7yoilsho	4079	3	demonstrate	demonstrate	VBP
cord-006229-7yoilsho	4079	4	strong	strong	JJ
cord-006229-7yoilsho	4079	5	differences	difference	NNS
cord-006229-7yoilsho	4079	6	in	in	IN
cord-006229-7yoilsho	4079	7	the	the	DT
cord-006229-7yoilsho	4079	8	substrate	substrate	NN
cord-006229-7yoilsho	4079	9	specificity	specificity	NN
cord-006229-7yoilsho	4079	10	between	between	IN
cord-006229-7yoilsho	4079	11	rodent	rodent	NN
cord-006229-7yoilsho	4079	12	and	and	CC
cord-006229-7yoilsho	4079	13	human	human	JJ
cord-006229-7yoilsho	4079	14	OCT1	OCT1	NNP
cord-006229-7yoilsho	4079	15	orthologs	ortholog	NNS
cord-006229-7yoilsho	4079	16	.	.	.
cord-006229-7yoilsho	4080	1	Therefore	therefore	RB
cord-006229-7yoilsho	4080	2	OCT1	OCT1	NNP
cord-006229-7yoilsho	4080	3	pharmacokinetic	pharmacokinetic	JJ
cord-006229-7yoilsho	4080	4	data	datum	NNS
cord-006229-7yoilsho	4080	5	obtained	obtain	VBN
cord-006229-7yoilsho	4080	6	in	in	IN
cord-006229-7yoilsho	4080	7	mouse	mouse	NN
cord-006229-7yoilsho	4080	8	or	or	CC
cord-006229-7yoilsho	4080	9	rat	rat	NN
cord-006229-7yoilsho	4080	10	models	model	NNS
cord-006229-7yoilsho	4080	11	could	could	MD
cord-006229-7yoilsho	4080	12	not	not	RB
cord-006229-7yoilsho	4080	13	be	be	VB
cord-006229-7yoilsho	4080	14	directly	directly	RB
cord-006229-7yoilsho	4080	15	extrapolated	extrapolate	VBN
cord-006229-7yoilsho	4080	16	for	for	IN
cord-006229-7yoilsho	4080	17	use	use	NN
cord-006229-7yoilsho	4080	18	in	in	IN
cord-006229-7yoilsho	4080	19	human	human	NN
cord-006229-7yoilsho	4080	20	.	.	.
cord-006229-7yoilsho	4081	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	4081	2	,	,	,
cord-006229-7yoilsho	4081	3	comparative	comparative	JJ
cord-006229-7yoilsho	4081	4	functional	functional	JJ
cord-006229-7yoilsho	4081	5	analyses	analysis	NNS
cord-006229-7yoilsho	4081	6	of	of	IN
cord-006229-7yoilsho	4081	7	orthologs	ortholog	NNS
cord-006229-7yoilsho	4081	8	may	may	MD
cord-006229-7yoilsho	4081	9	help	help	VB
cord-006229-7yoilsho	4081	10	reveal	reveal	VB
cord-006229-7yoilsho	4081	11	the	the	DT
cord-006229-7yoilsho	4081	12	mechanisms	mechanism	NNS
cord-006229-7yoilsho	4081	13	underlying	underlie	VBG
cord-006229-7yoilsho	4081	14	polyspecificity	polyspecificity	NN
cord-006229-7yoilsho	4081	15	of	of	IN
cord-006229-7yoilsho	4081	16	OCT1	OCT1	NNP
cord-006229-7yoilsho	4081	17	.	.	.
cord-006229-7yoilsho	4082	1	Ranitidine	Ranitidine	NNP
cord-006229-7yoilsho	4082	2	is	be	VBZ
cord-006229-7yoilsho	4082	3	a	a	DT
cord-006229-7yoilsho	4082	4	histamine	histamine	NN
cord-006229-7yoilsho	4082	5	H	h	NN
cord-006229-7yoilsho	4082	6	2	2	CD
cord-006229-7yoilsho	4082	7	-receptor	-receptor	NN
cord-006229-7yoilsho	4082	8	antagonist	antagonist	NN
cord-006229-7yoilsho	4082	9	which	which	WDT
cord-006229-7yoilsho	4082	10	is	be	VBZ
cord-006229-7yoilsho	4082	11	commonly	commonly	RB
cord-006229-7yoilsho	4082	12	used	use	VBN
cord-006229-7yoilsho	4082	13	without	without	IN
cord-006229-7yoilsho	4082	14	prescription	prescription	NN
cord-006229-7yoilsho	4082	15	for	for	IN
cord-006229-7yoilsho	4082	16	the	the	DT
cord-006229-7yoilsho	4082	17	treatment	treatment	NN
cord-006229-7yoilsho	4082	18	of	of	IN
cord-006229-7yoilsho	4082	19	pyrosis	pyrosis	NN
cord-006229-7yoilsho	4082	20	and	and	CC
cord-006229-7yoilsho	4082	21	gastric	gastric	JJ
cord-006229-7yoilsho	4082	22	ulcers	ulcer	NNS
cord-006229-7yoilsho	4082	23	.	.	.
cord-006229-7yoilsho	4083	1	Approximately	approximately	RB
cord-006229-7yoilsho	4083	2	30	30	CD
cord-006229-7yoilsho	4083	3	%	%	NN
cord-006229-7yoilsho	4083	4	of	of	IN
cord-006229-7yoilsho	4083	5	the	the	DT
cord-006229-7yoilsho	4083	6	systemic	systemic	JJ
cord-006229-7yoilsho	4083	7	clearance	clearance	NN
cord-006229-7yoilsho	4083	8	of	of	IN
cord-006229-7yoilsho	4083	9	ranitidine	ranitidine	NN
cord-006229-7yoilsho	4083	10	is	be	VBZ
cord-006229-7yoilsho	4083	11	via	via	IN
cord-006229-7yoilsho	4083	12	hepatic	hepatic	JJ
cord-006229-7yoilsho	4083	13	metabolism	metabolism	NN
cord-006229-7yoilsho	4083	14	.	.	.
cord-006229-7yoilsho	4084	1	Ranitidine	Ranitidine	NNP
cord-006229-7yoilsho	4084	2	is	be	VBZ
cord-006229-7yoilsho	4084	3	known	know	VBN
cord-006229-7yoilsho	4084	4	to	to	TO
cord-006229-7yoilsho	4084	5	be	be	VB
cord-006229-7yoilsho	4084	6	a	a	DT
cord-006229-7yoilsho	4084	7	substrate	substrate	NN
cord-006229-7yoilsho	4084	8	of	of	IN
cord-006229-7yoilsho	4084	9	the	the	DT
cord-006229-7yoilsho	4084	10	hepatic	hepatic	JJ
cord-006229-7yoilsho	4084	11	organic	organic	JJ
cord-006229-7yoilsho	4084	12	cation	cation	NN
cord-006229-7yoilsho	4084	13	transporter	transporter	NN
cord-006229-7yoilsho	4084	14	OCT1	OCT1	NNP
cord-006229-7yoilsho	4084	15	[	[	-LRB-
cord-006229-7yoilsho	4084	16	1	1	CD
cord-006229-7yoilsho	4084	17	]	]	-RRB-
cord-006229-7yoilsho	4084	18	.	.	.
cord-006229-7yoilsho	4085	1	OCT1	OCT1	NNP
cord-006229-7yoilsho	4085	2	is	be	VBZ
cord-006229-7yoilsho	4085	3	expressed	express	VBN
cord-006229-7yoilsho	4085	4	on	on	IN
cord-006229-7yoilsho	4085	5	the	the	DT
cord-006229-7yoilsho	4085	6	sinusoidal	sinusoidal	JJ
cord-006229-7yoilsho	4085	7	membrane	membrane	NN
cord-006229-7yoilsho	4085	8	of	of	IN
cord-006229-7yoilsho	4085	9	human	human	JJ
cord-006229-7yoilsho	4085	10	hepatocytes	hepatocyte	NNS
cord-006229-7yoilsho	4085	11	and	and	CC
cord-006229-7yoilsho	4085	12	is	be	VBZ
cord-006229-7yoilsho	4085	13	highly	highly	RB
cord-006229-7yoilsho	4085	14	genetically	genetically	RB
cord-006229-7yoilsho	4085	15	variable	variable	JJ
cord-006229-7yoilsho	4085	16	.	.	.
cord-006229-7yoilsho	4086	1	Sixteen	sixteen	CD
cord-006229-7yoilsho	4086	2	major	major	JJ
cord-006229-7yoilsho	4086	3	OCT1	OCT1	NNP
cord-006229-7yoilsho	4086	4	alleles	allele	NNS
cord-006229-7yoilsho	4086	5	are	be	VBP
cord-006229-7yoilsho	4086	6	known	know	VBN
cord-006229-7yoilsho	4086	7	[	[	-LRB-
cord-006229-7yoilsho	4086	8	2	2	CD
cord-006229-7yoilsho	4086	9	]	]	-RRB-
cord-006229-7yoilsho	4086	10	.	.	.
cord-006229-7yoilsho	4087	1	Thereof	thereof	IN
cord-006229-7yoilsho	4087	2	12	12	CD
cord-006229-7yoilsho	4087	3	alleles	allele	NNS
cord-006229-7yoilsho	4087	4	confer	confer	VBP
cord-006229-7yoilsho	4087	5	partial	partial	JJ
cord-006229-7yoilsho	4087	6	or	or	CC
cord-006229-7yoilsho	4087	7	complete	complete	JJ
cord-006229-7yoilsho	4087	8	loss	loss	NN
cord-006229-7yoilsho	4087	9	of	of	IN
cord-006229-7yoilsho	4087	10	OCT1	OCT1	NNP
cord-006229-7yoilsho	4087	11	activity	activity	NN
cord-006229-7yoilsho	4087	12	.	.	.
cord-006229-7yoilsho	4088	1	The	the	DT
cord-006229-7yoilsho	4088	2	observed	observed	JJ
cord-006229-7yoilsho	4088	3	loss	loss	NN
cord-006229-7yoilsho	4088	4	of	of	IN
cord-006229-7yoilsho	4088	5	activity	activity	NN
cord-006229-7yoilsho	4088	6	was	be	VBD
cord-006229-7yoilsho	4088	7	highly	highly	RB
cord-006229-7yoilsho	4088	8	substrate	substrate	JJ
cord-006229-7yoilsho	4088	9	specific	specific	JJ
cord-006229-7yoilsho	4088	10	and	and	CC
cord-006229-7yoilsho	4088	11	should	should	MD
cord-006229-7yoilsho	4088	12	be	be	VB
cord-006229-7yoilsho	4088	13	analyzed	analyze	VBN
cord-006229-7yoilsho	4088	14	substrate	substrate	NN
cord-006229-7yoilsho	4088	15	by	by	IN
cord-006229-7yoilsho	4088	16	substrate	substrate	NN
cord-006229-7yoilsho	4088	17	.	.	.
cord-006229-7yoilsho	4089	1	In	in	IN
cord-006229-7yoilsho	4089	2	this	this	DT
cord-006229-7yoilsho	4089	3	study	study	NN
cord-006229-7yoilsho	4089	4	we	-PRON-	PRP
cord-006229-7yoilsho	4089	5	analyzed	analyze	VBD
cord-006229-7yoilsho	4089	6	the	the	DT
cord-006229-7yoilsho	4089	7	effects	effect	NNS
cord-006229-7yoilsho	4089	8	of	of	IN
cord-006229-7yoilsho	4089	9	genetic	genetic	JJ
cord-006229-7yoilsho	4089	10	polymorphisms	polymorphism	NNS
cord-006229-7yoilsho	4089	11	in	in	IN
cord-006229-7yoilsho	4089	12	OCT1	OCT1	NNP
cord-006229-7yoilsho	4089	13	on	on	IN
cord-006229-7yoilsho	4089	14	the	the	DT
cord-006229-7yoilsho	4089	15	uptake	uptake	NN
cord-006229-7yoilsho	4089	16	of	of	IN
cord-006229-7yoilsho	4089	17	ranitidine	ranitidine	NN
cord-006229-7yoilsho	4089	18	.	.	.
cord-006229-7yoilsho	4090	1	We	-PRON-	PRP
cord-006229-7yoilsho	4090	2	used	use	VBD
cord-006229-7yoilsho	4090	3	HEK293	HEK293	NNP
cord-006229-7yoilsho	4090	4	cells	cell	NNS
cord-006229-7yoilsho	4090	5	stably	stably	RB
cord-006229-7yoilsho	4090	6	transfected	transfecte	VBN
cord-006229-7yoilsho	4090	7	to	to	TO
cord-006229-7yoilsho	4090	8	overexpress	overexpress	VB
cord-006229-7yoilsho	4090	9	wild	wild	JJ
cord-006229-7yoilsho	4090	10	type	type	NN
cord-006229-7yoilsho	4090	11	or	or	CC
cord-006229-7yoilsho	4090	12	variant	variant	NN
cord-006229-7yoilsho	4090	13	OCT1	OCT1	NNP
cord-006229-7yoilsho	4090	14	isoforms	isoform	NNS
cord-006229-7yoilsho	4090	15	.	.	.
cord-006229-7yoilsho	4091	1	The	the	DT
cord-006229-7yoilsho	4091	2	variant	variant	JJ
cord-006229-7yoilsho	4091	3	OCT1	OCT1	NNP
cord-006229-7yoilsho	4091	4	alleles	allele	NNS
cord-006229-7yoilsho	4091	5	OCT1	OCT1	NNP
cord-006229-7yoilsho	4091	6	*	*	NFP
cord-006229-7yoilsho	4091	7	1A	1a	NN
cord-006229-7yoilsho	4091	8	(	(	-LRB-
cord-006229-7yoilsho	4091	9	Met408Val	Met408Val	NNP
cord-006229-7yoilsho	4091	10	)	)	-RRB-
cord-006229-7yoilsho	4091	11	,	,	,
cord-006229-7yoilsho	4091	12	OCT1	OCT1	NNP
cord-006229-7yoilsho	4091	13	*	*	NFP
cord-006229-7yoilsho	4091	14	1C	1c	NN
cord-006229-7yoilsho	4091	15	(	(	-LRB-
cord-006229-7yoilsho	4091	16	Phe160Leu	Phe160Leu	NNP
cord-006229-7yoilsho	4091	17	)	)	-RRB-
cord-006229-7yoilsho	4091	18	,	,	,
cord-006229-7yoilsho	4091	19	OCT1	OCT1	NNP
cord-006229-7yoilsho	4091	20	*	*	NFP
cord-006229-7yoilsho	4091	21	1D	1d	CD
cord-006229-7yoilsho	4091	22	(	(	-LRB-
cord-006229-7yoilsho	4091	23	Pro341Leu	Pro341Leu	NNP
cord-006229-7yoilsho	4091	24	/	/	SYM
cord-006229-7yoilsho	4091	25	Met408Val	Met408Val	NNP
cord-006229-7yoilsho	4091	26	)	)	-RRB-
cord-006229-7yoilsho	4091	27	,	,	,
cord-006229-7yoilsho	4091	28	OCT1	OCT1	NNP
cord-006229-7yoilsho	4091	29	*	*	NFP
cord-006229-7yoilsho	4091	30	2	2	CD
cord-006229-7yoilsho	4091	31	(	(	-LRB-
cord-006229-7yoilsho	4091	32	Met420del	Met420del	NNP
cord-006229-7yoilsho	4091	33	)	)	-RRB-
cord-006229-7yoilsho	4091	34	,	,	,
cord-006229-7yoilsho	4091	35	OCT1	OCT1	NNP
cord-006229-7yoilsho	4091	36	*	*	NFP
cord-006229-7yoilsho	4091	37	3	3	CD
cord-006229-7yoilsho	4091	38	(	(	-LRB-
cord-006229-7yoilsho	4091	39	Arg61Cys	Arg61Cys	NNP
cord-006229-7yoilsho	4091	40	)	)	-RRB-
cord-006229-7yoilsho	4091	41	,	,	,
cord-006229-7yoilsho	4091	42	OCT1	OCT1	NNP
cord-006229-7yoilsho	4091	43	*	*	NFP
cord-006229-7yoilsho	4091	44	4	4	CD
cord-006229-7yoilsho	4091	45	(	(	-LRB-
cord-006229-7yoilsho	4091	46	Gly401Ser	Gly401Ser	NNP
cord-006229-7yoilsho	4091	47	)	)	-RRB-
cord-006229-7yoilsho	4091	48	,	,	,
cord-006229-7yoilsho	4091	49	OCT1	OCT1	NNP
cord-006229-7yoilsho	4091	50	*	*	NFP
cord-006229-7yoilsho	4091	51	5	5	CD
cord-006229-7yoilsho	4091	52	(	(	-LRB-
cord-006229-7yoilsho	4091	53	Gly465Arg	Gly465Arg	NNP
cord-006229-7yoilsho	4091	54	/	/	SYM
cord-006229-7yoilsho	4091	55	Met420del	Met420del	NNP
cord-006229-7yoilsho	4091	56	)	)	-RRB-
cord-006229-7yoilsho	4091	57	,	,	,
cord-006229-7yoilsho	4091	58	OCT1	OCT1	NNP
cord-006229-7yoilsho	4091	59	*	*	NFP
cord-006229-7yoilsho	4091	60	6	6	CD
cord-006229-7yoilsho	4091	61	(	(	-LRB-
cord-006229-7yoilsho	4091	62	Cys88Arg	cys88arg	NN
cord-006229-7yoilsho	4091	63	/	/	SYM
cord-006229-7yoilsho	4091	64	Met420del	Met420del	NNP
cord-006229-7yoilsho	4091	65	)	)	-RRB-
cord-006229-7yoilsho	4091	66	,	,	,
cord-006229-7yoilsho	4091	67	OCT1	OCT1	NNP
cord-006229-7yoilsho	4091	68	*	*	NFP
cord-006229-7yoilsho	4091	69	7	7	CD
cord-006229-7yoilsho	4091	70	(	(	-LRB-
cord-006229-7yoilsho	4091	71	Ser14Phe	Ser14Phe	NNP
cord-006229-7yoilsho	4091	72	)	)	-RRB-
cord-006229-7yoilsho	4091	73	,	,	,
cord-006229-7yoilsho	4091	74	OCT1	OCT1	NNP
cord-006229-7yoilsho	4091	75	*	*	NFP
cord-006229-7yoilsho	4091	76	8	8	CD
cord-006229-7yoilsho	4091	77	(	(	-LRB-
cord-006229-7yoilsho	4091	78	Arg488Met	Arg488Met	NNP
cord-006229-7yoilsho	4091	79	)	)	-RRB-
cord-006229-7yoilsho	4091	80	,	,	,
cord-006229-7yoilsho	4091	81	OCT1	OCT1	NNP
cord-006229-7yoilsho	4091	82	*	*	NFP
cord-006229-7yoilsho	4091	83	9	9	CD
cord-006229-7yoilsho	4091	84	(	(	-LRB-
cord-006229-7yoilsho	4091	85	Pro117Leu	pro117leu	CD
cord-006229-7yoilsho	4091	86	)	)	-RRB-
cord-006229-7yoilsho	4091	87	,	,	,
cord-006229-7yoilsho	4091	88	OCT1	OCT1	NNP
cord-006229-7yoilsho	4091	89	*	*	NFP
cord-006229-7yoilsho	4091	90	10	10	CD
cord-006229-7yoilsho	4091	91	(	(	-LRB-
cord-006229-7yoilsho	4091	92	Ser189Leu	Ser189Leu	NNP
cord-006229-7yoilsho	4091	93	)	)	-RRB-
cord-006229-7yoilsho	4091	94	,	,	,
cord-006229-7yoilsho	4091	95	OCT1	OCT1	NNP
cord-006229-7yoilsho	4091	96	*	*	NFP
cord-006229-7yoilsho	4091	97	11	11	CD
cord-006229-7yoilsho	4091	98	(	(	-LRB-
cord-006229-7yoilsho	4091	99	Ile449Thr	ile449thr	CD
cord-006229-7yoilsho	4091	100	)	)	-RRB-
cord-006229-7yoilsho	4091	101	,	,	,
cord-006229-7yoilsho	4091	102	OCT1	OCT1	NNP
cord-006229-7yoilsho	4091	103	*	*	NFP
cord-006229-7yoilsho	4091	104	12	12	CD
cord-006229-7yoilsho	4091	105	(	(	-LRB-
cord-006229-7yoilsho	4091	106	Ser29Leu	ser29leu	NN
cord-006229-7yoilsho	4091	107	)	)	-RRB-
cord-006229-7yoilsho	4091	108	and	and	CC
cord-006229-7yoilsho	4091	109	OCT1	OCT1	NNP
cord-006229-7yoilsho	4091	110	*	*	NFP
cord-006229-7yoilsho	4091	111	13	13	CD
cord-006229-7yoilsho	4091	112	(	(	-LRB-
cord-006229-7yoilsho	4091	113	Thr245Met	thr245met	CD
cord-006229-7yoilsho	4091	114	)	)	-RRB-
cord-006229-7yoilsho	4091	115	were	be	VBD
cord-006229-7yoilsho	4091	116	analyzed	analyze	VBN
cord-006229-7yoilsho	4091	117	.	.	.
cord-006229-7yoilsho	4092	1	We	-PRON-	PRP
cord-006229-7yoilsho	4092	2	characterized	characterize	VBD
cord-006229-7yoilsho	4092	3	in	in	IN
cord-006229-7yoilsho	4092	4	ranitidine	ranitidine	NN
cord-006229-7yoilsho	4092	5	uptake	uptake	NN
cord-006229-7yoilsho	4092	6	determined	determine	VBD
cord-006229-7yoilsho	4092	7	K	K	NNP
cord-006229-7yoilsho	4092	8	M	M	NNP
cord-006229-7yoilsho	4092	9	and	and	CC
cord-006229-7yoilsho	4092	10	v	v	NNP
cord-006229-7yoilsho	4092	11	max	max	NN
cord-006229-7yoilsho	4092	12	for	for	IN
cord-006229-7yoilsho	4092	13	the	the	DT
cord-006229-7yoilsho	4092	14	different	different	JJ
cord-006229-7yoilsho	4092	15	polymorphic	polymorphic	JJ
cord-006229-7yoilsho	4092	16	OCT1	OCT1	NNP
cord-006229-7yoilsho	4092	17	isoforms	isoform	NNS
cord-006229-7yoilsho	4092	18	.	.	.
cord-006229-7yoilsho	4093	1	Wild	wild	JJ
cord-006229-7yoilsho	4093	2	type	type	NN
cord-006229-7yoilsho	4093	3	OCT1	OCT1	NNP
cord-006229-7yoilsho	4093	4	showed	show	VBD
cord-006229-7yoilsho	4093	5	a	a	DT
cord-006229-7yoilsho	4093	6	time	time	NN
cord-006229-7yoilsho	4093	7	and	and	CC
cord-006229-7yoilsho	4093	8	concentration	concentration	NN
cord-006229-7yoilsho	4093	9	dependent	dependent	JJ
cord-006229-7yoilsho	4093	10	uptake	uptake	NN
cord-006229-7yoilsho	4093	11	of	of	IN
cord-006229-7yoilsho	4093	12	ranitidine	ranitidine	NN
cord-006229-7yoilsho	4093	13	with	with	IN
cord-006229-7yoilsho	4093	14	a	a	DT
cord-006229-7yoilsho	4093	15	K	K	NNP
cord-006229-7yoilsho	4093	16	M	M	NNP
cord-006229-7yoilsho	4093	17	of	of	IN
cord-006229-7yoilsho	4093	18	62.91	62.91	CD
cord-006229-7yoilsho	4093	19	±	±	CD
cord-006229-7yoilsho	4093	20	4.32	4.32	CD
cord-006229-7yoilsho	4093	21	µM	µM	NNP
cord-006229-7yoilsho	4093	22	and	and	CC
cord-006229-7yoilsho	4093	23	a	a	DT
cord-006229-7yoilsho	4093	24	v	v	NN
cord-006229-7yoilsho	4093	25	max	max	NN
cord-006229-7yoilsho	4093	26	of	of	IN
cord-006229-7yoilsho	4093	27	1125.41	1125.41	CD
cord-006229-7yoilsho	4093	28	±	±	CD
cord-006229-7yoilsho	4093	29	86.12	86.12	CD
cord-006229-7yoilsho	4093	30	pmol	pmol	NN
cord-006229-7yoilsho	4093	31	/	/	SYM
cord-006229-7yoilsho	4093	32	min	min	NNP
cord-006229-7yoilsho	4093	33	/	/	SYM
cord-006229-7yoilsho	4093	34	mg	mg	NNP
cord-006229-7yoilsho	4093	35	protein	protein	NN
cord-006229-7yoilsho	4093	36	.	.	.
cord-006229-7yoilsho	4094	1	Variants	Variants	NNPS
cord-006229-7yoilsho	4094	2	OCT1	OCT1	NNP
cord-006229-7yoilsho	4094	3	*	*	NFP
cord-006229-7yoilsho	4094	4	5	5	CD
cord-006229-7yoilsho	4094	5	,	,	,
cord-006229-7yoilsho	4094	6	OCT1	OCT1	NNP
cord-006229-7yoilsho	4094	7	*	*	NFP
cord-006229-7yoilsho	4094	8	6	6	CD
cord-006229-7yoilsho	4094	9	,	,	,
cord-006229-7yoilsho	4094	10	OCT1	OCT1	NNP
cord-006229-7yoilsho	4095	1	*	*	NFP
cord-006229-7yoilsho	4095	2	12	12	CD
cord-006229-7yoilsho	4095	3	and	and	CC
cord-006229-7yoilsho	4095	4	OCT1	OCT1	NNP
cord-006229-7yoilsho	4095	5	*	*	NFP
cord-006229-7yoilsho	4095	6	13	13	CD
cord-006229-7yoilsho	4095	7	completely	completely	RB
cord-006229-7yoilsho	4095	8	lacked	lack	VBD
cord-006229-7yoilsho	4095	9	ranitidine	ranitidine	NN
cord-006229-7yoilsho	4095	10	transport	transport	NN
cord-006229-7yoilsho	4095	11	activity	activity	NN
cord-006229-7yoilsho	4095	12	.	.	.
cord-006229-7yoilsho	4096	1	Variants	Variants	NNPS
cord-006229-7yoilsho	4096	2	OCT1	OCT1	NNP
cord-006229-7yoilsho	4096	3	*	*	NFP
cord-006229-7yoilsho	4096	4	2	2	CD
cord-006229-7yoilsho	4096	5	,	,	,
cord-006229-7yoilsho	4096	6	OCT1	OCT1	NNP
cord-006229-7yoilsho	4096	7	*	*	NFP
cord-006229-7yoilsho	4096	8	3	3	CD
cord-006229-7yoilsho	4096	9	,	,	,
cord-006229-7yoilsho	4097	1	OCT1	OCT1	NNP
cord-006229-7yoilsho	4097	2	*	*	NFP
cord-006229-7yoilsho	4097	3	4	4	CD
cord-006229-7yoilsho	4097	4	and	and	CC
cord-006229-7yoilsho	4097	5	OCT1	OCT1	NNP
cord-006229-7yoilsho	4097	6	*	*	NFP
cord-006229-7yoilsho	4097	7	10	10	CD
cord-006229-7yoilsho	4097	8	showed	show	VBD
cord-006229-7yoilsho	4097	9	v	v	IN
cord-006229-7yoilsho	4097	10	max	max	NN
cord-006229-7yoilsho	4097	11	values	value	NNS
cord-006229-7yoilsho	4097	12	decreased	decrease	VBD
cord-006229-7yoilsho	4097	13	by	by	IN
cord-006229-7yoilsho	4097	14	64	64	CD
cord-006229-7yoilsho	4097	15	,	,	,
cord-006229-7yoilsho	4097	16	77	77	CD
cord-006229-7yoilsho	4097	17	,	,	,
cord-006229-7yoilsho	4097	18	91	91	CD
cord-006229-7yoilsho	4097	19	and	and	CC
cord-006229-7yoilsho	4097	20	50	50	CD
cord-006229-7yoilsho	4097	21	%	%	NN
cord-006229-7yoilsho	4097	22	,	,	,
cord-006229-7yoilsho	4097	23	respectively	respectively	RB
cord-006229-7yoilsho	4097	24	.	.	.
cord-006229-7yoilsho	4098	1	OCT1	OCT1	NNP
cord-006229-7yoilsho	4098	2	*	*	NFP
cord-006229-7yoilsho	4098	3	8	8	CD
cord-006229-7yoilsho	4098	4	variant	variant	NN
cord-006229-7yoilsho	4098	5	showed	show	VBD
cord-006229-7yoilsho	4098	6	an	an	DT
cord-006229-7yoilsho	4098	7	increase	increase	NN
cord-006229-7yoilsho	4098	8	of	of	IN
cord-006229-7yoilsho	4098	9	v	v	CD
cord-006229-7yoilsho	4098	10	max	max	NN
cord-006229-7yoilsho	4098	11	by	by	IN
cord-006229-7yoilsho	4098	12	25	25	CD
cord-006229-7yoilsho	4098	13	%	%	NN
cord-006229-7yoilsho	4098	14	.	.	.
cord-006229-7yoilsho	4099	1	There	there	EX
cord-006229-7yoilsho	4099	2	was	be	VBD
cord-006229-7yoilsho	4099	3	no	no	DT
cord-006229-7yoilsho	4099	4	significant	significant	JJ
cord-006229-7yoilsho	4099	5	changes	change	NNS
cord-006229-7yoilsho	4099	6	in	in	IN
cord-006229-7yoilsho	4099	7	ranitidine	ranitidine	NN
cord-006229-7yoilsho	4099	8	uptake	uptake	NN
cord-006229-7yoilsho	4099	9	by	by	IN
cord-006229-7yoilsho	4099	10	variants	variant	NNS
cord-006229-7yoilsho	4099	11	OCT1	OCT1	NNP
cord-006229-7yoilsho	4099	12	*	*	NFP
cord-006229-7yoilsho	4099	13	1A	1a	NN
cord-006229-7yoilsho	4099	14	,	,	,
cord-006229-7yoilsho	4100	1	OCT1	OCT1	NNP
cord-006229-7yoilsho	4100	2	*	*	NFP
cord-006229-7yoilsho	4100	3	1C	1c	NN
cord-006229-7yoilsho	4100	4	,	,	,
cord-006229-7yoilsho	4100	5	OCT1	OCT1	NNP
cord-006229-7yoilsho	4100	6	*	*	NFP
cord-006229-7yoilsho	4100	7	1D	1d	CD
cord-006229-7yoilsho	4100	8	,	,	,
cord-006229-7yoilsho	4100	9	OCT1	OCT1	NNP
cord-006229-7yoilsho	4100	10	*	*	NFP
cord-006229-7yoilsho	4100	11	7	7	CD
cord-006229-7yoilsho	4100	12	,	,	,
cord-006229-7yoilsho	4100	13	OCT1	OCT1	NNP
cord-006229-7yoilsho	4100	14	*	*	NFP
cord-006229-7yoilsho	4100	15	9	9	CD
cord-006229-7yoilsho	4100	16	and	and	CC
cord-006229-7yoilsho	4101	1	OCT1	OCT1	NNP
cord-006229-7yoilsho	4101	2	*	*	NFP
cord-006229-7yoilsho	4101	3	11	11	CD
cord-006229-7yoilsho	4101	4	compared	compare	VBN
cord-006229-7yoilsho	4101	5	to	to	IN
cord-006229-7yoilsho	4101	6	the	the	DT
cord-006229-7yoilsho	4101	7	wild	wild	JJ
cord-006229-7yoilsho	4101	8	type	type	NN
cord-006229-7yoilsho	4101	9	.	.	.
cord-006229-7yoilsho	4102	1	There	there	EX
cord-006229-7yoilsho	4102	2	were	be	VBD
cord-006229-7yoilsho	4102	3	no	no	DT
cord-006229-7yoilsho	4102	4	significant	significant	JJ
cord-006229-7yoilsho	4102	5	differences	difference	NNS
cord-006229-7yoilsho	4102	6	in	in	IN
cord-006229-7yoilsho	4102	7	the	the	DT
cord-006229-7yoilsho	4102	8	K	K	NNP
cord-006229-7yoilsho	4102	9	M	M	NNP
cord-006229-7yoilsho	4102	10	values	value	NNS
cord-006229-7yoilsho	4102	11	between	between	IN
cord-006229-7yoilsho	4102	12	the	the	DT
cord-006229-7yoilsho	4102	13	wild	wild	JJ
cord-006229-7yoilsho	4102	14	-	-	HYPH
cord-006229-7yoilsho	4102	15	type	type	NN
cord-006229-7yoilsho	4102	16	and	and	CC
cord-006229-7yoilsho	4102	17	variants	variant	NNS
cord-006229-7yoilsho	4102	18	.	.	.
cord-006229-7yoilsho	4103	1	In	in	IN
cord-006229-7yoilsho	4103	2	conclusion	conclusion	NN
cord-006229-7yoilsho	4103	3	,	,	,
cord-006229-7yoilsho	4103	4	we	-PRON-	PRP
cord-006229-7yoilsho	4103	5	confirmed	confirm	VBD
cord-006229-7yoilsho	4103	6	ranitidine	ranitidine	NN
cord-006229-7yoilsho	4103	7	as	as	IN
cord-006229-7yoilsho	4103	8	an	an	DT
cord-006229-7yoilsho	4103	9	OCT1	OCT1	NNP
cord-006229-7yoilsho	4103	10	substrate	substrate	NN
cord-006229-7yoilsho	4103	11	and	and	CC
cord-006229-7yoilsho	4103	12	demonstrated	demonstrate	VBD
cord-006229-7yoilsho	4103	13	that	that	IN
cord-006229-7yoilsho	4103	14	genetic	genetic	JJ
cord-006229-7yoilsho	4103	15	polymorphisms	polymorphism	NNS
cord-006229-7yoilsho	4103	16	in	in	IN
cord-006229-7yoilsho	4103	17	OCT1	OCT1	NNP
cord-006229-7yoilsho	4103	18	can	can	MD
cord-006229-7yoilsho	4103	19	strongly	strongly	RB
cord-006229-7yoilsho	4103	20	affect	affect	VB
cord-006229-7yoilsho	4103	21	ranitidine	ranitidine	NN
cord-006229-7yoilsho	4103	22	uptake	uptake	NN
cord-006229-7yoilsho	4103	23	.	.	.
cord-006229-7yoilsho	4104	1	The	the	DT
cord-006229-7yoilsho	4104	2	effects	effect	NNS
cord-006229-7yoilsho	4104	3	of	of	IN
cord-006229-7yoilsho	4104	4	OCT1	OCT1	NNP
cord-006229-7yoilsho	4104	5	polymorphisms	polymorphism	NNS
cord-006229-7yoilsho	4104	6	on	on	IN
cord-006229-7yoilsho	4104	7	ranitidine	ranitidine	NN
cord-006229-7yoilsho	4104	8	pharmacokinetics	pharmacokinetic	NNS
cord-006229-7yoilsho	4104	9	in	in	IN
cord-006229-7yoilsho	4104	10	humans	human	NNS
cord-006229-7yoilsho	4104	11	remain	remain	VBP
cord-006229-7yoilsho	4104	12	to	to	TO
cord-006229-7yoilsho	4104	13	be	be	VB
cord-006229-7yoilsho	4104	14	analyzed	analyze	VBN
cord-006229-7yoilsho	4104	15	.	.	.
cord-006229-7yoilsho	4105	1	Otto	Otto	NNP
cord-006229-7yoilsho	4105	2	-	-	HYPH
cord-006229-7yoilsho	4105	3	von	von	NNP
cord-006229-7yoilsho	4105	4	-	-	HYPH
cord-006229-7yoilsho	4105	5	Guericke	Guericke	NNP
cord-006229-7yoilsho	4105	6	University	University	NNP
cord-006229-7yoilsho	4105	7	,	,	,
cord-006229-7yoilsho	4105	8	Institute	Institute	NNP
cord-006229-7yoilsho	4105	9	for	for	IN
cord-006229-7yoilsho	4105	10	Pharmacology	Pharmacology	NNP
cord-006229-7yoilsho	4105	11	and	and	CC
cord-006229-7yoilsho	4105	12	Toxicology	Toxicology	NNP
cord-006229-7yoilsho	4105	13	,	,	,
cord-006229-7yoilsho	4105	14	Magdeburg	Magdeburg	NNP
cord-006229-7yoilsho	4105	15	,	,	,
cord-006229-7yoilsho	4106	1	Germany	Germany	NNP
cord-006229-7yoilsho	4106	2	Serotonergic	Serotonergic	NNP
cord-006229-7yoilsho	4107	1	hallucinogens	hallucinogen	NNS
cord-006229-7yoilsho	4107	2	(	(	-LRB-
cord-006229-7yoilsho	4107	3	s	s	NNP
cord-006229-7yoilsho	4107	4	HGs	HGs	NNPS
cord-006229-7yoilsho	4107	5	)	)	-RRB-
cord-006229-7yoilsho	4107	6	,	,	,
cord-006229-7yoilsho	4107	7	such	such	JJ
cord-006229-7yoilsho	4107	8	as	as	IN
cord-006229-7yoilsho	4107	9	lysergic	lysergic	JJ
cord-006229-7yoilsho	4107	10	acid	acid	NN
cord-006229-7yoilsho	4108	1	diethylamide	diethylamide	NN
cord-006229-7yoilsho	4108	2	(	(	-LRB-
cord-006229-7yoilsho	4108	3	LSD	LSD	NNP
cord-006229-7yoilsho	4108	4	)	)	-RRB-
cord-006229-7yoilsho	4108	5	,	,	.
cord-006229-7yoilsho	4109	1	induce	induce	VB
cord-006229-7yoilsho	4109	2	profound	profound	JJ
cord-006229-7yoilsho	4109	3	alterations	alteration	NNS
cord-006229-7yoilsho	4109	4	of	of	IN
cord-006229-7yoilsho	4109	5	human	human	JJ
cord-006229-7yoilsho	4109	6	consciousness	consciousness	NN
cord-006229-7yoilsho	4109	7	,	,	,
cord-006229-7yoilsho	4109	8	which	which	WDT
cord-006229-7yoilsho	4109	9	are	be	VBP
cord-006229-7yoilsho	4109	10	thought	think	VBN
cord-006229-7yoilsho	4109	11	to	to	TO
cord-006229-7yoilsho	4109	12	be	be	VB
cord-006229-7yoilsho	4109	13	mediated	mediate	VBN
cord-006229-7yoilsho	4109	14	by	by	IN
cord-006229-7yoilsho	4109	15	activation	activation	NN
cord-006229-7yoilsho	4109	16	of	of	IN
cord-006229-7yoilsho	4109	17	5-HT	5-ht	CD
cord-006229-7yoilsho	4109	18	2A	2a	CD
cord-006229-7yoilsho	4109	19	receptors	receptor	NNS
cord-006229-7yoilsho	4109	20	.	.	.
cord-006229-7yoilsho	4110	1	With	with	IN
cord-006229-7yoilsho	4110	2	repeated	repeated	JJ
cord-006229-7yoilsho	4110	3	application	application	NN
cord-006229-7yoilsho	4110	4	,	,	,
cord-006229-7yoilsho	4110	5	the	the	DT
cord-006229-7yoilsho	4110	6	mind	mind	NN
cord-006229-7yoilsho	4110	7	-	-	HYPH
cord-006229-7yoilsho	4110	8	altering	alter	VBG
cord-006229-7yoilsho	4110	9	effects	effect	NNS
cord-006229-7yoilsho	4110	10	of	of	IN
cord-006229-7yoilsho	4110	11	most	most	JJS
cord-006229-7yoilsho	4110	12	s	s	POS
cord-006229-7yoilsho	4110	13	HGs	hg	NNS
cord-006229-7yoilsho	4110	14	rapidly	rapidly	RB
cord-006229-7yoilsho	4110	15	are	be	VBP
cord-006229-7yoilsho	4110	16	undermined	undermine	VBN
cord-006229-7yoilsho	4110	17	by	by	IN
cord-006229-7yoilsho	4110	18	tolerance	tolerance	NN
cord-006229-7yoilsho	4110	19	.	.	.
cord-006229-7yoilsho	4111	1	The	the	DT
cord-006229-7yoilsho	4111	2	only	only	JJ
cord-006229-7yoilsho	4111	3	exception	exception	NN
cord-006229-7yoilsho	4111	4	seems	seem	VBZ
cord-006229-7yoilsho	4111	5	to	to	TO
cord-006229-7yoilsho	4111	6	be	be	VB
cord-006229-7yoilsho	4111	7	dimethyltryptamine	dimethyltryptamine	JJ
cord-006229-7yoilsho	4111	8	(	(	-LRB-
cord-006229-7yoilsho	4111	9	DMT	DMT	NNP
cord-006229-7yoilsho	4111	10	)	)	-RRB-
cord-006229-7yoilsho	4111	11	,	,	,
cord-006229-7yoilsho	4111	12	whose	whose	WP$
cord-006229-7yoilsho	4111	13	mind	mind	NN
cord-006229-7yoilsho	4111	14	-	-	HYPH
cord-006229-7yoilsho	4111	15	altering	alter	VBG
cord-006229-7yoilsho	4111	16	effects	effect	NNS
cord-006229-7yoilsho	4111	17	for	for	IN
cord-006229-7yoilsho	4111	18	reasons	reason	NNS
cord-006229-7yoilsho	4111	19	unknown	unknown	JJ
cord-006229-7yoilsho	4111	20	even	even	RB
cord-006229-7yoilsho	4111	21	with	with	IN
cord-006229-7yoilsho	4111	22	repeated	repeat	VBN
cord-006229-7yoilsho	4111	23	application	application	NN
cord-006229-7yoilsho	4111	24	do	do	VBP
cord-006229-7yoilsho	4111	25	not	not	RB
cord-006229-7yoilsho	4111	26	decrease	decrease	VB
cord-006229-7yoilsho	4111	27	.	.	.
cord-006229-7yoilsho	4112	1	Assuming	assume	VBG
cord-006229-7yoilsho	4112	2	that	that	IN
cord-006229-7yoilsho	4112	3	DMT	DMT	NNP
cord-006229-7yoilsho	4112	4	differs	differ	VBZ
cord-006229-7yoilsho	4112	5	from	from	IN
cord-006229-7yoilsho	4112	6	other	other	JJ
cord-006229-7yoilsho	4112	7	s	s	NNP
cord-006229-7yoilsho	4112	8	HGs	hg	NNS
cord-006229-7yoilsho	4112	9	in	in	IN
cord-006229-7yoilsho	4112	10	its	-PRON-	PRP$
cord-006229-7yoilsho	4112	11	capacity	capacity	NN
cord-006229-7yoilsho	4112	12	to	to	TO
cord-006229-7yoilsho	4112	13	regulate	regulate	VB
cord-006229-7yoilsho	4112	14	5-HT	5-ht	CD
cord-006229-7yoilsho	4112	15	2A	2a	CD
cord-006229-7yoilsho	4112	16	receptors	receptor	NNS
cord-006229-7yoilsho	4112	17	,	,	,
cord-006229-7yoilsho	4112	18	we	-PRON-	PRP
cord-006229-7yoilsho	4112	19	here	here	RB
cord-006229-7yoilsho	4112	20	compare	compare	VBP
cord-006229-7yoilsho	4112	21	LSD	LSD	NNP
cord-006229-7yoilsho	4112	22	and	and	CC
cord-006229-7yoilsho	4112	23	DMT	DMT	NNP
cord-006229-7yoilsho	4112	24	with	with	IN
cord-006229-7yoilsho	4112	25	regard	regard	NN
cord-006229-7yoilsho	4112	26	to	to	IN
cord-006229-7yoilsho	4112	27	processes	process	NNS
cord-006229-7yoilsho	4112	28	of	of	IN
cord-006229-7yoilsho	4112	29	5-HT	5-ht	CD
cord-006229-7yoilsho	4112	30	2A	2a	CD
cord-006229-7yoilsho	4112	31	downregulation	downregulation	NN
cord-006229-7yoilsho	4112	32	.	.	.
cord-006229-7yoilsho	4113	1	In	in	IN
cord-006229-7yoilsho	4113	2	heat	heat	NN
cord-006229-7yoilsho	4113	3	-	-	HYPH
cord-006229-7yoilsho	4113	4	exposed	expose	VBN
cord-006229-7yoilsho	4113	5	rats	rat	NNS
cord-006229-7yoilsho	4113	6	,	,	,
cord-006229-7yoilsho	4113	7	LSD	LSD	NNP
cord-006229-7yoilsho	4113	8	and	and	CC
cord-006229-7yoilsho	4113	9	DMT	DMT	NNP
cord-006229-7yoilsho	4113	10	induce	induce	VB
cord-006229-7yoilsho	4113	11	a	a	DT
cord-006229-7yoilsho	4113	12	marked	marked	JJ
cord-006229-7yoilsho	4113	13	increase	increase	NN
cord-006229-7yoilsho	4113	14	in	in	IN
cord-006229-7yoilsho	4113	15	body	body	NN
cord-006229-7yoilsho	4113	16	core	core	NN
cord-006229-7yoilsho	4113	17	temperature	temperature	NN
cord-006229-7yoilsho	4113	18	(	(	-LRB-
cord-006229-7yoilsho	4113	19	hyperthermia	hyperthermia	NN
cord-006229-7yoilsho	4113	20	)	)	-RRB-
cord-006229-7yoilsho	4113	21	accompanied	accompany	VBN
cord-006229-7yoilsho	4113	22	by	by	IN
cord-006229-7yoilsho	4113	23	"	"	``
cord-006229-7yoilsho	4113	24	defensive	defensive	JJ
cord-006229-7yoilsho	4113	25	hypersalivation	hypersalivation	NN
cord-006229-7yoilsho	4113	26	"	"	''
cord-006229-7yoilsho	4113	27	.	.	.
cord-006229-7yoilsho	4114	1	Both	both	DT
cord-006229-7yoilsho	4114	2	effects	effect	NNS
cord-006229-7yoilsho	4114	3	are	be	VBP
cord-006229-7yoilsho	4114	4	mimicked	mimic	VBN
cord-006229-7yoilsho	4114	5	by	by	IN
cord-006229-7yoilsho	4114	6	the	the	DT
cord-006229-7yoilsho	4114	7	5-HT	5-ht	CD
cord-006229-7yoilsho	4114	8	2	2	CD
cord-006229-7yoilsho	4114	9	selective	selective	JJ
cord-006229-7yoilsho	4114	10	agonist	agonist	NN
cord-006229-7yoilsho	4114	11	dimethoxybromoamphetamine	dimethoxybromoamphetamine	NN
cord-006229-7yoilsho	4114	12	(	(	-LRB-
cord-006229-7yoilsho	4114	13	DOB	DOB	NNP
cord-006229-7yoilsho	4114	14	)	)	-RRB-
cord-006229-7yoilsho	4114	15	and	and	CC
cord-006229-7yoilsho	4114	16	can	can	MD
cord-006229-7yoilsho	4114	17	be	be	VB
cord-006229-7yoilsho	4114	18	blocked	block	VBN
cord-006229-7yoilsho	4114	19	by	by	IN
cord-006229-7yoilsho	4114	20	the	the	DT
cord-006229-7yoilsho	4114	21	selective	selective	JJ
cord-006229-7yoilsho	4114	22	5-HT	5-ht	CD
cord-006229-7yoilsho	4114	23	2A	2a	CD
cord-006229-7yoilsho	4114	24	antagonists	antagonist	NNS
cord-006229-7yoilsho	4114	25	ketanserin	ketanserin	NNP
cord-006229-7yoilsho	4114	26	and	and	CC
cord-006229-7yoilsho	4114	27	MDL100907	MDL100907	NNP
cord-006229-7yoilsho	4114	28	.	.	.
cord-006229-7yoilsho	4115	1	After	after	IN
cord-006229-7yoilsho	4115	2	repeated	repeat	VBN
cord-006229-7yoilsho	4115	3	application	application	NN
cord-006229-7yoilsho	4115	4	,	,	,
cord-006229-7yoilsho	4115	5	the	the	DT
cord-006229-7yoilsho	4115	6	temperatureregulatory	temperatureregulatory	NNP
cord-006229-7yoilsho	4115	7	effects	effect	NNS
cord-006229-7yoilsho	4115	8	of	of	IN
cord-006229-7yoilsho	4115	9	LSD	LSD	NNP
cord-006229-7yoilsho	4115	10	are	be	VBP
cord-006229-7yoilsho	4115	11	subject	subject	JJ
cord-006229-7yoilsho	4115	12	to	to	IN
cord-006229-7yoilsho	4115	13	tolerance	tolerance	NN
cord-006229-7yoilsho	4115	14	,	,	,
cord-006229-7yoilsho	4115	15	whereas	whereas	IN
cord-006229-7yoilsho	4115	16	the	the	DT
cord-006229-7yoilsho	4115	17	ones	one	NNS
cord-006229-7yoilsho	4115	18	of	of	IN
cord-006229-7yoilsho	4115	19	DMT	DMT	NNP
cord-006229-7yoilsho	4115	20	are	be	VBP
cord-006229-7yoilsho	4115	21	not	not	RB
cord-006229-7yoilsho	4115	22	.	.	.
cord-006229-7yoilsho	4116	1	Tolerance	tolerance	NN
cord-006229-7yoilsho	4116	2	to	to	IN
cord-006229-7yoilsho	4116	3	LSD	LSD	NNP
cord-006229-7yoilsho	4116	4	(	(	-LRB-
cord-006229-7yoilsho	4116	5	as	as	IN
cord-006229-7yoilsho	4116	6	measured	measure	VBN
cord-006229-7yoilsho	4116	7	by	by	IN
cord-006229-7yoilsho	4116	8	DOB	DOB	NNP
cord-006229-7yoilsho	4116	9	induced	induce	VBN
cord-006229-7yoilsho	4116	10	[	[	-LRB-
cord-006229-7yoilsho	4116	11	35	35	CD
cord-006229-7yoilsho	4116	12	S]GTPуS	S]GTPуS	NNP
cord-006229-7yoilsho	4116	13	binding	binding	NN
cord-006229-7yoilsho	4116	14	)	)	-RRB-
cord-006229-7yoilsho	4116	15	is	be	VBZ
cord-006229-7yoilsho	4116	16	paralleled	parallel	VBN
cord-006229-7yoilsho	4116	17	by	by	IN
cord-006229-7yoilsho	4116	18	a	a	DT
cord-006229-7yoilsho	4116	19	desensitisation	desensitisation	NN
cord-006229-7yoilsho	4116	20	of	of	IN
cord-006229-7yoilsho	4116	21	frontocortical	frontocortical	JJ
cord-006229-7yoilsho	4116	22	5-HT	5-ht	CD
cord-006229-7yoilsho	4116	23	2	2	CD
cord-006229-7yoilsho	4116	24	receptors	receptor	NNS
cord-006229-7yoilsho	4116	25	;	;	:
cord-006229-7yoilsho	4116	26	for	for	IN
cord-006229-7yoilsho	4116	27	DMT	DMT	NNP
cord-006229-7yoilsho	4116	28	,	,	,
cord-006229-7yoilsho	4116	29	there	there	EX
cord-006229-7yoilsho	4116	30	is	be	VBZ
cord-006229-7yoilsho	4116	31	no	no	DT
cord-006229-7yoilsho	4116	32	such	such	JJ
cord-006229-7yoilsho	4116	33	decrease	decrease	NN
cord-006229-7yoilsho	4116	34	.	.	.
cord-006229-7yoilsho	4117	1	Applying	apply	VBG
cord-006229-7yoilsho	4117	2	techniques	technique	NNS
cord-006229-7yoilsho	4117	3	of	of	IN
cord-006229-7yoilsho	4117	4	immunocytochemistry	immunocytochemistry	NN
cord-006229-7yoilsho	4117	5	,	,	,
cord-006229-7yoilsho	4117	6	transphosphatidylation	transphosphatidylation	NN
cord-006229-7yoilsho	4117	7	,	,	,
cord-006229-7yoilsho	4117	8	and	and	CC
cord-006229-7yoilsho	4117	9	quantitative	quantitative	JJ
cord-006229-7yoilsho	4117	10	real	real	JJ
cord-006229-7yoilsho	4117	11	-	-	HYPH
cord-006229-7yoilsho	4117	12	time	time	NN
cord-006229-7yoilsho	4117	13	PCR	PCR	NNP
cord-006229-7yoilsho	4117	14	to	to	IN
cord-006229-7yoilsho	4117	15	(	(	-LRB-
cord-006229-7yoilsho	4117	16	HA-5-HT	HA-5-HT	NNP
cord-006229-7yoilsho	4117	17	2A	2a	CD
cord-006229-7yoilsho	4117	18	transfected	transfecte	VBN
cord-006229-7yoilsho	4117	19	)	)	-RRB-
cord-006229-7yoilsho	4118	1	HEK293	HEK293	NNP
cord-006229-7yoilsho	4118	2	and	and	CC
cord-006229-7yoilsho	4118	3	(	(	-LRB-
cord-006229-7yoilsho	4118	4	endogenously	endogenously	RB
cord-006229-7yoilsho	4118	5	5-HT	5-ht	CD
cord-006229-7yoilsho	4118	6	2A	2a	CD
cord-006229-7yoilsho	4118	7	expressing	express	VBG
cord-006229-7yoilsho	4118	8	)	)	-RRB-
cord-006229-7yoilsho	4118	9	C6	c6	NN
cord-006229-7yoilsho	4118	10	glioma	glioma	NN
cord-006229-7yoilsho	4118	11	cells	cell	NNS
cord-006229-7yoilsho	4118	12	,	,	,
cord-006229-7yoilsho	4118	13	respectively	respectively	RB
cord-006229-7yoilsho	4118	14	,	,	,
cord-006229-7yoilsho	4118	15	we	-PRON-	PRP
cord-006229-7yoilsho	4118	16	furthermore	furthermore	RB
cord-006229-7yoilsho	4118	17	demonstrate	demonstrate	VBP
cord-006229-7yoilsho	4118	18	that	that	IN
cord-006229-7yoilsho	4118	19	DMT	DMT	NNP
cord-006229-7yoilsho	4118	20	in	in	IN
cord-006229-7yoilsho	4118	21	contrast	contrast	NN
cord-006229-7yoilsho	4118	22	to	to	IN
cord-006229-7yoilsho	4118	23	LSD	LSD	NNP
cord-006229-7yoilsho	4118	24	fails	fail	VBZ
cord-006229-7yoilsho	4118	25	to	to	TO
cord-006229-7yoilsho	4118	26	internalise	internalise	VB
cord-006229-7yoilsho	4118	27	5-HT	5-ht	CD
cord-006229-7yoilsho	4118	28	2A	2a	CD
cord-006229-7yoilsho	4118	29	receptors	receptor	NNS
cord-006229-7yoilsho	4118	30	,	,	,
cord-006229-7yoilsho	4118	31	fails	fail	VBZ
cord-006229-7yoilsho	4118	32	to	to	TO
cord-006229-7yoilsho	4118	33	activate	activate	VB
cord-006229-7yoilsho	4118	34	the	the	DT
cord-006229-7yoilsho	4118	35	phospholipase	phospholipase	NN
cord-006229-7yoilsho	4118	36	D	d	NN
cord-006229-7yoilsho	4118	37	(	(	-LRB-
cord-006229-7yoilsho	4118	38	which	which	WDT
cord-006229-7yoilsho	4118	39	is	be	VBZ
cord-006229-7yoilsho	4118	40	needed	need	VBN
cord-006229-7yoilsho	4118	41	for	for	IN
cord-006229-7yoilsho	4118	42	5-HT	5-ht	CD
cord-006229-7yoilsho	4118	43	2A	2a	CD
cord-006229-7yoilsho	4118	44	internalisation	internalisation	NN
cord-006229-7yoilsho	4118	45	)	)	-RRB-
cord-006229-7yoilsho	4118	46	,	,	,
cord-006229-7yoilsho	4118	47	and	and	CC
cord-006229-7yoilsho	4118	48	fails	fail	VBZ
cord-006229-7yoilsho	4118	49	to	to	TO
cord-006229-7yoilsho	4118	50	inhibit	inhibit	VB
cord-006229-7yoilsho	4118	51	the	the	DT
cord-006229-7yoilsho	4118	52	synthesis	synthesis	NN
cord-006229-7yoilsho	4118	53	of	of	IN
cord-006229-7yoilsho	4118	54	5-HT	5-ht	CD
cord-006229-7yoilsho	4118	55	2A	2a	CD
cord-006229-7yoilsho	4118	56	receptors	receptor	NNS
cord-006229-7yoilsho	4118	57	.	.	.
cord-006229-7yoilsho	4119	1	Given	give	VBN
cord-006229-7yoilsho	4119	2	that	that	DT
cord-006229-7yoilsho	4119	3	DMT	DMT	NNP
cord-006229-7yoilsho	4119	4	unlike	unlike	IN
cord-006229-7yoilsho	4119	5	LSD	LSD	NNP
cord-006229-7yoilsho	4119	6	turns	turn	VBZ
cord-006229-7yoilsho	4119	7	out	out	RP
cord-006229-7yoilsho	4119	8	to	to	TO
cord-006229-7yoilsho	4119	9	be	be	VB
cord-006229-7yoilsho	4119	10	inactive	inactive	JJ
cord-006229-7yoilsho	4119	11	as	as	IN
cord-006229-7yoilsho	4119	12	to	to	IN
cord-006229-7yoilsho	4119	13	all	all	DT
cord-006229-7yoilsho	4119	14	processes	process	NNS
cord-006229-7yoilsho	4119	15	of	of	IN
cord-006229-7yoilsho	4119	16	5-HT	5-ht	CD
cord-006229-7yoilsho	4119	17	2A	2a	CD
cord-006229-7yoilsho	4119	18	downregulation	downregulation	NN
cord-006229-7yoilsho	4119	19	investigated	investigate	VBN
cord-006229-7yoilsho	4119	20	,	,	,
cord-006229-7yoilsho	4119	21	our	-PRON-	PRP$
cord-006229-7yoilsho	4119	22	data	datum	NNS
cord-006229-7yoilsho	4119	23	suggest	suggest	VBP
cord-006229-7yoilsho	4119	24	that	that	IN
cord-006229-7yoilsho	4119	25	the	the	DT
cord-006229-7yoilsho	4119	26	differential	differential	JJ
cord-006229-7yoilsho	4119	27	tolerance	tolerance	NN
cord-006229-7yoilsho	4119	28	development	development	NN
cord-006229-7yoilsho	4119	29	noted	note	VBN
cord-006229-7yoilsho	4119	30	for	for	IN
cord-006229-7yoilsho	4119	31	DMT	DMT	NNP
cord-006229-7yoilsho	4119	32	and	and	CC
cord-006229-7yoilsho	4119	33	LSD	LSD	NNP
cord-006229-7yoilsho	4119	34	indeed	indeed	RB
cord-006229-7yoilsho	4119	35	might	may	MD
cord-006229-7yoilsho	4119	36	be	be	VB
cord-006229-7yoilsho	4119	37	accounted	account	VBN
cord-006229-7yoilsho	4119	38	for	for	IN
cord-006229-7yoilsho	4119	39	by	by	IN
cord-006229-7yoilsho	4119	40	differential	differential	JJ
cord-006229-7yoilsho	4119	41	regulation	regulation	NN
cord-006229-7yoilsho	4119	42	of	of	IN
cord-006229-7yoilsho	4119	43	5-HT	5-ht	CD
cord-006229-7yoilsho	4119	44	2A	2a	CD
cord-006229-7yoilsho	4119	45	receptors	receptor	NNS
cord-006229-7yoilsho	4119	46	.	.	.
cord-006229-7yoilsho	4120	1	LSD	LSD	NNP
cord-006229-7yoilsho	4120	2	and	and	CC
cord-006229-7yoilsho	4120	3	DMT	DMT	NNP
cord-006229-7yoilsho	4120	4	both	both	DT
cord-006229-7yoilsho	4120	5	have	have	VBP
cord-006229-7yoilsho	4120	6	recently	recently	RB
cord-006229-7yoilsho	4120	7	regained	regain	VBN
cord-006229-7yoilsho	4120	8	scientific	scientific	JJ
cord-006229-7yoilsho	4120	9	attention	attention	NN
cord-006229-7yoilsho	4120	10	as	as	IN
cord-006229-7yoilsho	4120	11	potential	potential	JJ
cord-006229-7yoilsho	4120	12	therapeutics	therapeutic	NNS
cord-006229-7yoilsho	4120	13	in	in	IN
cord-006229-7yoilsho	4120	14	the	the	DT
cord-006229-7yoilsho	4120	15	treatment	treatment	NN
cord-006229-7yoilsho	4120	16	of	of	IN
cord-006229-7yoilsho	4120	17	depression	depression	NN
cord-006229-7yoilsho	4120	18	and/or	and/or	CC
cord-006229-7yoilsho	4120	19	anxiety	anxiety	NN
cord-006229-7yoilsho	4120	20	disorders	disorder	NNS
cord-006229-7yoilsho	4120	21	.	.	.
cord-006229-7yoilsho	4121	1	Providing	provide	VBG
cord-006229-7yoilsho	4121	2	mechanistic	mechanistic	JJ
cord-006229-7yoilsho	4121	3	insights	insight	NNS
cord-006229-7yoilsho	4121	4	into	into	IN
cord-006229-7yoilsho	4121	5	their	-PRON-	PRP$
cord-006229-7yoilsho	4121	6	action	action	NN
cord-006229-7yoilsho	4121	7	,	,	,
cord-006229-7yoilsho	4121	8	thus	thus	RB
cord-006229-7yoilsho	4121	9	,	,	,
cord-006229-7yoilsho	4121	10	is	be	VBZ
cord-006229-7yoilsho	4121	11	of	of	IN
cord-006229-7yoilsho	4121	12	timely	timely	RB
cord-006229-7yoilsho	4121	13	clinical	clinical	JJ
cord-006229-7yoilsho	4121	14	relevance	relevance	NN
cord-006229-7yoilsho	4121	15	.	.	.
cord-006229-7yoilsho	4122	1	Increased	increase	VBN
cord-006229-7yoilsho	4122	2	GABA	GABA	NNP
cord-006229-7yoilsho	4122	3	release	release	NN
cord-006229-7yoilsho	4122	4	in	in	IN
cord-006229-7yoilsho	4122	5	human	human	JJ
cord-006229-7yoilsho	4122	6	neocortex	neocortex	NN
cord-006229-7yoilsho	4122	7	at	at	IN
cord-006229-7yoilsho	4122	8	high	high	JJ
cord-006229-7yoilsho	4122	9	intracellular	intracellular	JJ
cord-006229-7yoilsho	4122	10	sodium	sodium	NN
cord-006229-7yoilsho	4122	11	and	and	CC
cord-006229-7yoilsho	4122	12	low	low	JJ
cord-006229-7yoilsho	4122	13	extracellular	extracellular	JJ
cord-006229-7yoilsho	4122	14	calcium	calcium	NN
cord-006229-7yoilsho	4122	15	-an	-an	:
cord-006229-7yoilsho	4122	16	anti	anti	JJ
cord-006229-7yoilsho	4122	17	-	-	JJ
cord-006229-7yoilsho	4122	18	seizure	seizure	JJ
cord-006229-7yoilsho	4122	19	mechanism	mechanism	NN
cord-006229-7yoilsho	4122	20	?	?	.
cord-006229-7yoilsho	4122	21	]	]	-RRB-
cord-006229-7yoilsho	4123	1	e	e	LS
cord-006229-7yoilsho	4123	2	,	,	,
cord-006229-7yoilsho	4123	3	this	this	DT
cord-006229-7yoilsho	4123	4	reduction	reduction	NN
cord-006229-7yoilsho	4123	5	might	may	MD
cord-006229-7yoilsho	4123	6	induce	induce	VB
cord-006229-7yoilsho	4123	7	an	an	DT
cord-006229-7yoilsho	4123	8	anti	anti	JJ
cord-006229-7yoilsho	4123	9	-	-	JJ
cord-006229-7yoilsho	4123	10	seizure	seizure	JJ
cord-006229-7yoilsho	4123	11	mechanism	mechanism	NN
cord-006229-7yoilsho	4123	12	by	by	IN
cord-006229-7yoilsho	4123	13	augmenting	augment	VBG
cord-006229-7yoilsho	4123	14	GAT	GAT	NNP
cord-006229-7yoilsho	4123	15	-	-	HYPH
cord-006229-7yoilsho	4123	16	mediated	mediate	VBN
cord-006229-7yoilsho	4123	17	GABA	GABA	NNP
cord-006229-7yoilsho	4123	18	release	release	NN
cord-006229-7yoilsho	4123	19	,	,	,
cord-006229-7yoilsho	4123	20	a	a	DT
cord-006229-7yoilsho	4123	21	mechanism	mechanism	NN
cord-006229-7yoilsho	4123	22	absent	absent	JJ
cord-006229-7yoilsho	4123	23	in	in	IN
cord-006229-7yoilsho	4123	24	rats	rat	NNS
cord-006229-7yoilsho	4123	25	.	.	.
cord-006229-7yoilsho	4124	1	Aging	age	VBG
cord-006229-7yoilsho	4124	2	is	be	VBZ
cord-006229-7yoilsho	4124	3	complex	complex	JJ
cord-006229-7yoilsho	4124	4	on	on	IN
cord-006229-7yoilsho	4124	5	the	the	DT
cord-006229-7yoilsho	4124	6	systems	system	NNS
cord-006229-7yoilsho	4124	7	as	as	RB
cord-006229-7yoilsho	4124	8	well	well	RB
cord-006229-7yoilsho	4124	9	as	as	IN
cord-006229-7yoilsho	4124	10	on	on	IN
cord-006229-7yoilsho	4124	11	the	the	DT
cord-006229-7yoilsho	4124	12	molecular	molecular	JJ
cord-006229-7yoilsho	4124	13	level	level	NN
cord-006229-7yoilsho	4124	14	.	.	.
cord-006229-7yoilsho	4125	1	The	the	DT
cord-006229-7yoilsho	4125	2	process	process	NN
cord-006229-7yoilsho	4125	3	of	of	IN
cord-006229-7yoilsho	4125	4	aging	age	VBG
cord-006229-7yoilsho	4125	5	is	be	VBZ
cord-006229-7yoilsho	4125	6	characterized	characterize	VBN
cord-006229-7yoilsho	4125	7	by	by	IN
cord-006229-7yoilsho	4125	8	a	a	DT
cord-006229-7yoilsho	4125	9	progressive	progressive	JJ
cord-006229-7yoilsho	4125	10	loss	loss	NN
cord-006229-7yoilsho	4125	11	of	of	IN
cord-006229-7yoilsho	4125	12	physiological	physiological	JJ
cord-006229-7yoilsho	4125	13	functions	function	NNS
cord-006229-7yoilsho	4125	14	and	and	CC
cord-006229-7yoilsho	4125	15	accumulation	accumulation	NN
cord-006229-7yoilsho	4125	16	of	of	IN
cord-006229-7yoilsho	4125	17	cellular	cellular	JJ
cord-006229-7yoilsho	4125	18	damage	damage	NN
cord-006229-7yoilsho	4125	19	.	.	.
cord-006229-7yoilsho	4126	1	One	one	CD
cord-006229-7yoilsho	4126	2	hallmark	hallmark	NN
cord-006229-7yoilsho	4126	3	of	of	IN
cord-006229-7yoilsho	4126	4	aging	age	VBG
cord-006229-7yoilsho	4126	5	is	be	VBZ
cord-006229-7yoilsho	4126	6	an	an	DT
cord-006229-7yoilsho	4126	7	impaired	impaired	JJ
cord-006229-7yoilsho	4126	8	protein	protein	NN
cord-006229-7yoilsho	4126	9	homeostasis	homeostasis	NN
cord-006229-7yoilsho	4126	10	.	.	.
cord-006229-7yoilsho	4127	1	The	the	DT
cord-006229-7yoilsho	4127	2	imbalance	imbalance	NN
cord-006229-7yoilsho	4127	3	of	of	IN
cord-006229-7yoilsho	4127	4	the	the	DT
cord-006229-7yoilsho	4127	5	quality	quality	NN
cord-006229-7yoilsho	4127	6	control	control	NN
cord-006229-7yoilsho	4127	7	of	of	IN
cord-006229-7yoilsho	4127	8	both	both	DT
cord-006229-7yoilsho	4127	9	de	de	FW
cord-006229-7yoilsho	4127	10	novo	novo	NNP
cord-006229-7yoilsho	4127	11	protein	protein	NNP
cord-006229-7yoilsho	4127	12	synthesis	synthesis	NN
cord-006229-7yoilsho	4127	13	and	and	CC
cord-006229-7yoilsho	4127	14	protein	protein	NN
cord-006229-7yoilsho	4127	15	degradation	degradation	NN
cord-006229-7yoilsho	4127	16	,	,	,
cord-006229-7yoilsho	4127	17	therefore	therefore	RB
cord-006229-7yoilsho	4127	18	,	,	,
cord-006229-7yoilsho	4127	19	is	be	VBZ
cord-006229-7yoilsho	4127	20	likely	likely	JJ
cord-006229-7yoilsho	4127	21	to	to	TO
cord-006229-7yoilsho	4127	22	contribute	contribute	VB
cord-006229-7yoilsho	4127	23	to	to	IN
cord-006229-7yoilsho	4127	24	the	the	DT
cord-006229-7yoilsho	4127	25	phenotype	phenotype	NN
cord-006229-7yoilsho	4127	26	of	of	IN
cord-006229-7yoilsho	4127	27	aging	age	VBG
cord-006229-7yoilsho	4127	28	.	.	.
cord-006229-7yoilsho	4128	1	We	-PRON-	PRP
cord-006229-7yoilsho	4128	2	investigated	investigate	VBD
cord-006229-7yoilsho	4128	3	protein	protein	NN
cord-006229-7yoilsho	4128	4	turnover	turnover	NN
cord-006229-7yoilsho	4128	5	rates	rate	NNS
cord-006229-7yoilsho	4128	6	with	with	IN
cord-006229-7yoilsho	4128	7	the	the	DT
cord-006229-7yoilsho	4128	8	state	state	NN
cord-006229-7yoilsho	4128	9	-	-	HYPH
cord-006229-7yoilsho	4128	10	of	of	IN
cord-006229-7yoilsho	4128	11	-	-	HYPH
cord-006229-7yoilsho	4128	12	the	the	DT
cord-006229-7yoilsho	4128	13	art	art	NN
cord-006229-7yoilsho	4128	14	techniques	technique	NNS
cord-006229-7yoilsho	4129	1	FUNCAT	FUNCAT	NNP
cord-006229-7yoilsho	4130	1	(	(	-LRB-
cord-006229-7yoilsho	4130	2	Dieterich	Dieterich	NNP
cord-006229-7yoilsho	4130	3	et	et	NNP
cord-006229-7yoilsho	4130	4	al	al	NNP
cord-006229-7yoilsho	4130	5	.	.	NNP
cord-006229-7yoilsho	4130	6	,	,	,
cord-006229-7yoilsho	4130	7	2010	2010	CD
cord-006229-7yoilsho	4130	8	)	)	-RRB-
cord-006229-7yoilsho	4130	9	and	and	CC
cord-006229-7yoilsho	4130	10	SUnSET	SUnSET	NNPS
cord-006229-7yoilsho	4130	11	(	(	-LRB-
cord-006229-7yoilsho	4130	12	Schmidt	Schmidt	NNP
cord-006229-7yoilsho	4130	13	et	et	NNP
cord-006229-7yoilsho	4130	14	al	al	NNP
cord-006229-7yoilsho	4130	15	.	.	NNP
cord-006229-7yoilsho	4130	16	,	,	,
cord-006229-7yoilsho	4130	17	2009	2009	CD
cord-006229-7yoilsho	4130	18	)	)	-RRB-
cord-006229-7yoilsho	4130	19	in	in	IN
cord-006229-7yoilsho	4130	20	aging	age	VBG
cord-006229-7yoilsho	4130	21	neuronal	neuronal	JJ
cord-006229-7yoilsho	4130	22	cell	cell	NN
cord-006229-7yoilsho	4130	23	cultures	culture	NNS
cord-006229-7yoilsho	4130	24	.	.	.
cord-006229-7yoilsho	4131	1	Using	use	VBG
cord-006229-7yoilsho	4131	2	these	these	DT
cord-006229-7yoilsho	4131	3	techniques	technique	NNS
cord-006229-7yoilsho	4131	4	we	-PRON-	PRP
cord-006229-7yoilsho	4131	5	show	show	VBP
cord-006229-7yoilsho	4131	6	a	a	DT
cord-006229-7yoilsho	4131	7	prominent	prominent	JJ
cord-006229-7yoilsho	4131	8	decrease	decrease	NN
cord-006229-7yoilsho	4131	9	in	in	IN
cord-006229-7yoilsho	4131	10	protein	protein	NN
cord-006229-7yoilsho	4131	11	synthesis	synthesis	NN
cord-006229-7yoilsho	4131	12	and	and	CC
cord-006229-7yoilsho	4131	13	degradation	degradation	NN
cord-006229-7yoilsho	4131	14	that	that	WDT
cord-006229-7yoilsho	4131	15	progressed	progress	VBD
cord-006229-7yoilsho	4131	16	gradually	gradually	RB
cord-006229-7yoilsho	4131	17	in	in	IN
cord-006229-7yoilsho	4131	18	aging	age	VBG
cord-006229-7yoilsho	4131	19	neuronal	neuronal	JJ
cord-006229-7yoilsho	4131	20	cells	cell	NNS
cord-006229-7yoilsho	4131	21	cultured	culture	VBN
cord-006229-7yoilsho	4131	22	up	up	RP
cord-006229-7yoilsho	4131	23	to	to	IN
cord-006229-7yoilsho	4131	24	DIV	DIV	NNP
cord-006229-7yoilsho	4131	25	60	60	CD
cord-006229-7yoilsho	4131	26	.	.	.
cord-006229-7yoilsho	4132	1	In	in	IN
cord-006229-7yoilsho	4132	2	order	order	NN
cord-006229-7yoilsho	4132	3	to	to	TO
cord-006229-7yoilsho	4132	4	rejuvenate	rejuvenate	VB
cord-006229-7yoilsho	4132	5	the	the	DT
cord-006229-7yoilsho	4132	6	protein	protein	NN
cord-006229-7yoilsho	4132	7	turnover	turnover	NN
cord-006229-7yoilsho	4132	8	in	in	IN
cord-006229-7yoilsho	4132	9	aged	aged	JJ
cord-006229-7yoilsho	4132	10	neuronal	neuronal	JJ
cord-006229-7yoilsho	4132	11	cells	cell	NNS
cord-006229-7yoilsho	4132	12	we	-PRON-	PRP
cord-006229-7yoilsho	4132	13	applied	apply	VBD
cord-006229-7yoilsho	4132	14	the	the	DT
cord-006229-7yoilsho	4132	15	selective	selective	JJ
cord-006229-7yoilsho	4132	16	eukaryotic	eukaryotic	JJ
cord-006229-7yoilsho	4132	17	elongation	elongation	NN
cord-006229-7yoilsho	4132	18	factor-2	factor-2	NNP
cord-006229-7yoilsho	4132	19	kinase	kinase	NN
cord-006229-7yoilsho	4132	20	inhibitor	inhibitor	NN
cord-006229-7yoilsho	4133	1	A	a	DT
cord-006229-7yoilsho	4133	2	484954	484954	CD
cord-006229-7yoilsho	4133	3	and	and	CC
cord-006229-7yoilsho	4133	4	the	the	DT
cord-006229-7yoilsho	4133	5	polyamine	polyamine	NN
cord-006229-7yoilsho	4133	6	Spermidine	Spermidine	NNP
cord-006229-7yoilsho	4133	7	and	and	CC
cord-006229-7yoilsho	4134	1	observed	observe	VBD
cord-006229-7yoilsho	4134	2	protein	protein	NN
cord-006229-7yoilsho	4134	3	translation	translation	NN
cord-006229-7yoilsho	4134	4	utilizing	utilize	VBG
cord-006229-7yoilsho	4134	5	FUNCAT	FUNCAT	NNP
cord-006229-7yoilsho	4134	6	and	and	CC
cord-006229-7yoilsho	4134	7	SUnSET	SUnSET	NNS
cord-006229-7yoilsho	4134	8	.	.	.
cord-006229-7yoilsho	4135	1	Whereas	whereas	IN
cord-006229-7yoilsho	4135	2	both	both	CC
cord-006229-7yoilsho	4135	3	A	a	DT
cord-006229-7yoilsho	4135	4	484954	484954	CD
cord-006229-7yoilsho	4135	5	and	and	CC
cord-006229-7yoilsho	4135	6	Spermidine	Spermidine	NNP
cord-006229-7yoilsho	4135	7	had	have	VBD
cord-006229-7yoilsho	4135	8	no	no	DT
cord-006229-7yoilsho	4135	9	effect	effect	NN
cord-006229-7yoilsho	4135	10	on	on	IN
cord-006229-7yoilsho	4135	11	de	de	NNP
cord-006229-7yoilsho	4135	12	novo	novo	NNP
cord-006229-7yoilsho	4135	13	protein	protein	NN
cord-006229-7yoilsho	4135	14	synthesis	synthesis	NN
cord-006229-7yoilsho	4135	15	in	in	IN
cord-006229-7yoilsho	4135	16	juvenile	juvenile	JJ
cord-006229-7yoilsho	4135	17	neurons	neuron	NNS
cord-006229-7yoilsho	4135	18	(	(	-LRB-
cord-006229-7yoilsho	4135	19	DIV	DIV	NNP
cord-006229-7yoilsho	4135	20	20	20	CD
cord-006229-7yoilsho	4135	21	)	)	-RRB-
cord-006229-7yoilsho	4135	22	,	,	,
cord-006229-7yoilsho	4135	23	both	both	DT
cord-006229-7yoilsho	4135	24	substances	substance	NNS
cord-006229-7yoilsho	4135	25	increased	increase	VBD
cord-006229-7yoilsho	4135	26	the	the	DT
cord-006229-7yoilsho	4135	27	de	de	FW
cord-006229-7yoilsho	4135	28	novo	novo	NNP
cord-006229-7yoilsho	4135	29	protein	protein	NNP
cord-006229-7yoilsho	4135	30	synthesis	synthesis	NN
cord-006229-7yoilsho	4135	31	to	to	IN
cord-006229-7yoilsho	4135	32	a	a	DT
cord-006229-7yoilsho	4135	33	juvenile	juvenile	JJ
cord-006229-7yoilsho	4135	34	level	level	NN
cord-006229-7yoilsho	4135	35	in	in	IN
cord-006229-7yoilsho	4135	36	aged	aged	JJ
cord-006229-7yoilsho	4135	37	neuronal	neuronal	JJ
cord-006229-7yoilsho	4135	38	cultures	culture	NNS
cord-006229-7yoilsho	4135	39	(	(	-LRB-
cord-006229-7yoilsho	4135	40	DIV60	DIV60	NNP
cord-006229-7yoilsho	4135	41	)	)	-RRB-
cord-006229-7yoilsho	4135	42	.	.	.
cord-006229-7yoilsho	4136	1	This	this	DT
cord-006229-7yoilsho	4136	2	effect	effect	NN
cord-006229-7yoilsho	4136	3	is	be	VBZ
cord-006229-7yoilsho	4136	4	seen	see	VBN
cord-006229-7yoilsho	4136	5	in	in	IN
cord-006229-7yoilsho	4136	6	neuronal	neuronal	JJ
cord-006229-7yoilsho	4136	7	somata	somata	NN
cord-006229-7yoilsho	4136	8	and	and	CC
cord-006229-7yoilsho	4136	9	dendritic	dendritic	JJ
cord-006229-7yoilsho	4136	10	spines	spine	NNS
cord-006229-7yoilsho	4136	11	.	.	.
cord-006229-7yoilsho	4137	1	The	the	DT
cord-006229-7yoilsho	4137	2	molecular	molecular	JJ
cord-006229-7yoilsho	4137	3	function	function	NN
cord-006229-7yoilsho	4137	4	of	of	IN
cord-006229-7yoilsho	4137	5	Spermidine	Spermidine	NNP
cord-006229-7yoilsho	4137	6	as	as	IN
cord-006229-7yoilsho	4137	7	an	an	DT
cord-006229-7yoilsho	4137	8	"	"	``
cord-006229-7yoilsho	4137	9	anti	anti	JJ
cord-006229-7yoilsho	4137	10	-	-	JJ
cord-006229-7yoilsho	4137	11	aging	aging	JJ
cord-006229-7yoilsho	4137	12	agent	agent	NN
cord-006229-7yoilsho	4137	13	"	"	``
cord-006229-7yoilsho	4137	14	is	be	VBZ
cord-006229-7yoilsho	4137	15	not	not	RB
cord-006229-7yoilsho	4137	16	defined	define	VBN
cord-006229-7yoilsho	4137	17	yet	yet	RB
cord-006229-7yoilsho	4137	18	.	.	.
cord-006229-7yoilsho	4138	1	Thus	thus	RB
cord-006229-7yoilsho	4138	2	,	,	,
cord-006229-7yoilsho	4138	3	additional	additional	JJ
cord-006229-7yoilsho	4138	4	pharmacological	pharmacological	JJ
cord-006229-7yoilsho	4138	5	interventions	intervention	NNS
cord-006229-7yoilsho	4138	6	are	be	VBP
cord-006229-7yoilsho	4138	7	used	use	VBN
cord-006229-7yoilsho	4138	8	for	for	IN
cord-006229-7yoilsho	4138	9	further	further	JJ
cord-006229-7yoilsho	4138	10	examination	examination	NN
cord-006229-7yoilsho	4138	11	of	of	IN
cord-006229-7yoilsho	4138	12	specific	specific	JJ
cord-006229-7yoilsho	4138	13	molecular	molecular	JJ
cord-006229-7yoilsho	4138	14	Spermidine	Spermidine	NNP
cord-006229-7yoilsho	4138	15	targets	target	NNS
cord-006229-7yoilsho	4138	16	.	.	.
cord-006229-7yoilsho	4139	1	In	in	IN
cord-006229-7yoilsho	4139	2	conclusion	conclusion	NN
cord-006229-7yoilsho	4139	3	,	,	,
cord-006229-7yoilsho	4139	4	the	the	DT
cord-006229-7yoilsho	4139	5	described	describe	VBN
cord-006229-7yoilsho	4139	6	experimental	experimental	JJ
cord-006229-7yoilsho	4139	7	setup	setup	NN
cord-006229-7yoilsho	4139	8	is	be	VBZ
cord-006229-7yoilsho	4139	9	used	use	VBN
cord-006229-7yoilsho	4139	10	to	to	TO
cord-006229-7yoilsho	4139	11	investigate	investigate	VB
cord-006229-7yoilsho	4139	12	impaired	impaired	JJ
cord-006229-7yoilsho	4139	13	protein	protein	NN
cord-006229-7yoilsho	4139	14	homeostasis	homeostasis	NN
cord-006229-7yoilsho	4139	15	as	as	IN
cord-006229-7yoilsho	4139	16	one	one	CD
cord-006229-7yoilsho	4139	17	hallmark	hallmark	NN
cord-006229-7yoilsho	4139	18	of	of	IN
cord-006229-7yoilsho	4139	19	aging	age	VBG
cord-006229-7yoilsho	4139	20	.	.	.
cord-006229-7yoilsho	4140	1	Agents	agent	NNS
cord-006229-7yoilsho	4140	2	with	with	IN
cord-006229-7yoilsho	4140	3	a	a	DT
cord-006229-7yoilsho	4140	4	presumed	presume	VBN
cord-006229-7yoilsho	4140	5	"	"	``
cord-006229-7yoilsho	4140	6	anti	anti	JJ
cord-006229-7yoilsho	4140	7	-	-	JJ
cord-006229-7yoilsho	4140	8	aging	aging	JJ
cord-006229-7yoilsho	4140	9	"	"	''
cord-006229-7yoilsho	4140	10	effect	effect	NN
cord-006229-7yoilsho	4140	11	can	can	MD
cord-006229-7yoilsho	4140	12	be	be	VB
cord-006229-7yoilsho	4140	13	tested	test	VBN
cord-006229-7yoilsho	4140	14	for	for	IN
cord-006229-7yoilsho	4140	15	a	a	DT
cord-006229-7yoilsho	4140	16	potential	potential	JJ
cord-006229-7yoilsho	4140	17	rejuvenating	rejuvenate	VBG
cord-006229-7yoilsho	4140	18	effect	effect	NN
cord-006229-7yoilsho	4140	19	on	on	IN
cord-006229-7yoilsho	4140	20	the	the	DT
cord-006229-7yoilsho	4140	21	level	level	NN
cord-006229-7yoilsho	4140	22	of	of	IN
cord-006229-7yoilsho	4140	23	protein	protein	NN
cord-006229-7yoilsho	4140	24	homeostasis	homeostasis	NN
cord-006229-7yoilsho	4140	25	.	.	.
cord-006229-7yoilsho	4141	1	A	a	DT
cord-006229-7yoilsho	4141	2	screening	screening	NN
cord-006229-7yoilsho	4141	3	approach	approach	NN
cord-006229-7yoilsho	4141	4	to	to	TO
cord-006229-7yoilsho	4141	5	test	test	VB
cord-006229-7yoilsho	4141	6	tolerability	tolerability	NN
cord-006229-7yoilsho	4141	7	of	of	IN
cord-006229-7yoilsho	4141	8	multitargeted	multitargete	VBN
cord-006229-7yoilsho	4141	9	drug	drug	NN
cord-006229-7yoilsho	4141	10	combinations	combination	NNS
cord-006229-7yoilsho	4141	11	for	for	IN
cord-006229-7yoilsho	4141	12	antiepileptogenesis	antiepileptogenesis	NN
cord-006229-7yoilsho	4141	13	in	in	IN
cord-006229-7yoilsho	4141	14	mice	mouse	NNS
cord-006229-7yoilsho	4142	1	A	a	DT
cord-006229-7yoilsho	4142	2	large	large	JJ
cord-006229-7yoilsho	4142	3	variety	variety	NN
cord-006229-7yoilsho	4142	4	of	of	IN
cord-006229-7yoilsho	4142	5	brain	brain	NN
cord-006229-7yoilsho	4142	6	insults	insult	NNS
cord-006229-7yoilsho	4142	7	can	can	MD
cord-006229-7yoilsho	4142	8	induce	induce	VB
cord-006229-7yoilsho	4142	9	the	the	DT
cord-006229-7yoilsho	4142	10	development	development	NN
cord-006229-7yoilsho	4142	11	of	of	IN
cord-006229-7yoilsho	4142	12	symptomatic	symptomatic	JJ
cord-006229-7yoilsho	4142	13	epilepsies	epilepsy	NNS
cord-006229-7yoilsho	4142	14	,	,	,
cord-006229-7yoilsho	4142	15	particularly	particularly	RB
cord-006229-7yoilsho	4142	16	temporal	temporal	JJ
cord-006229-7yoilsho	4142	17	lobe	lobe	NN
cord-006229-7yoilsho	4142	18	epilepsy	epilepsy	NN
cord-006229-7yoilsho	4142	19	.	.	.
cord-006229-7yoilsho	4143	1	In	in	IN
cord-006229-7yoilsho	4143	2	the	the	DT
cord-006229-7yoilsho	4143	3	latent	latent	JJ
cord-006229-7yoilsho	4143	4	period	period	NN
cord-006229-7yoilsho	4143	5	after	after	IN
cord-006229-7yoilsho	4143	6	the	the	DT
cord-006229-7yoilsho	4143	7	initial	initial	JJ
cord-006229-7yoilsho	4143	8	insult	insult	NN
cord-006229-7yoilsho	4143	9	multiple	multiple	JJ
cord-006229-7yoilsho	4143	10	molecular	molecular	JJ
cord-006229-7yoilsho	4143	11	,	,	,
cord-006229-7yoilsho	4143	12	structural	structural	JJ
cord-006229-7yoilsho	4143	13	,	,	,
cord-006229-7yoilsho	4143	14	and	and	CC
cord-006229-7yoilsho	4143	15	functional	functional	JJ
cord-006229-7yoilsho	4143	16	changes	change	NNS
cord-006229-7yoilsho	4143	17	proceed	proceed	VBP
cord-006229-7yoilsho	4143	18	in	in	IN
cord-006229-7yoilsho	4143	19	the	the	DT
cord-006229-7yoilsho	4143	20	brain	brain	NN
cord-006229-7yoilsho	4143	21	and	and	CC
cord-006229-7yoilsho	4143	22	finally	finally	RB
cord-006229-7yoilsho	4143	23	lead	lead	VB
cord-006229-7yoilsho	4143	24	to	to	IN
cord-006229-7yoilsho	4143	25	spontaneous	spontaneous	JJ
cord-006229-7yoilsho	4143	26	recurrent	recurrent	JJ
cord-006229-7yoilsho	4143	27	seizures	seizure	NNS
cord-006229-7yoilsho	4143	28	.	.	.
cord-006229-7yoilsho	4144	1	Prevention	prevention	NN
cord-006229-7yoilsho	4144	2	of	of	IN
cord-006229-7yoilsho	4144	3	these	these	DT
cord-006229-7yoilsho	4144	4	developments	development	NNS
cord-006229-7yoilsho	4144	5	,	,	,
cord-006229-7yoilsho	4144	6	called	call	VBN
cord-006229-7yoilsho	4144	7	antiepileptogenesis	antiepileptogenesis	NNP
cord-006229-7yoilsho	4144	8	,	,	,
cord-006229-7yoilsho	4144	9	in	in	IN
cord-006229-7yoilsho	4144	10	patients	patient	NNS
cord-006229-7yoilsho	4144	11	at	at	IN
cord-006229-7yoilsho	4144	12	risk	risk	NN
cord-006229-7yoilsho	4144	13	is	be	VBZ
cord-006229-7yoilsho	4144	14	a	a	DT
cord-006229-7yoilsho	4144	15	major	major	JJ
cord-006229-7yoilsho	4144	16	unmet	unmet	JJ
cord-006229-7yoilsho	4144	17	clinical	clinical	JJ
cord-006229-7yoilsho	4144	18	need	need	NN
cord-006229-7yoilsho	4144	19	.	.	.
cord-006229-7yoilsho	4145	1	Several	several	JJ
cord-006229-7yoilsho	4145	2	drugs	drug	NNS
cord-006229-7yoilsho	4145	3	underwent	undergo	VBD
cord-006229-7yoilsho	4145	4	clinical	clinical	JJ
cord-006229-7yoilsho	4145	5	trials	trial	NNS
cord-006229-7yoilsho	4145	6	for	for	IN
cord-006229-7yoilsho	4145	7	epilepsy	epilepsy	NN
cord-006229-7yoilsho	4145	8	prevention	prevention	NN
cord-006229-7yoilsho	4145	9	,	,	,
cord-006229-7yoilsho	4145	10	but	but	CC
cord-006229-7yoilsho	4145	11	none	none	NN
cord-006229-7yoilsho	4145	12	of	of	IN
cord-006229-7yoilsho	4145	13	the	the	DT
cord-006229-7yoilsho	4145	14	drugs	drug	NNS
cord-006229-7yoilsho	4145	15	tested	test	VBN
cord-006229-7yoilsho	4145	16	was	be	VBD
cord-006229-7yoilsho	4145	17	effective	effective	JJ
cord-006229-7yoilsho	4145	18	.	.	.
cord-006229-7yoilsho	4146	1	Similarly	similarly	RB
cord-006229-7yoilsho	4146	2	,	,	,
cord-006229-7yoilsho	4146	3	most	most	RBS
cord-006229-7yoilsho	4146	4	previous	previous	JJ
cord-006229-7yoilsho	4146	5	preclinical	preclinical	JJ
cord-006229-7yoilsho	4146	6	attempts	attempt	NNS
cord-006229-7yoilsho	4146	7	to	to	TO
cord-006229-7yoilsho	4146	8	develop	develop	VB
cord-006229-7yoilsho	4146	9	antiepileptogenic	antiepileptogenic	NNP
cord-006229-7yoilsho	4146	10	strategies	strategy	NNS
cord-006229-7yoilsho	4146	11	failed	fail	VBD
cord-006229-7yoilsho	4146	12	.	.	.
cord-006229-7yoilsho	4147	1	In	in	IN
cord-006229-7yoilsho	4147	2	the	the	DT
cord-006229-7yoilsho	4147	3	majority	majority	NN
cord-006229-7yoilsho	4147	4	of	of	IN
cord-006229-7yoilsho	4147	5	studies	study	NNS
cord-006229-7yoilsho	4147	6	,	,	,
cord-006229-7yoilsho	4147	7	drugs	drug	NNS
cord-006229-7yoilsho	4147	8	were	be	VBD
cord-006229-7yoilsho	4147	9	given	give	VBN
cord-006229-7yoilsho	4147	10	as	as	IN
cord-006229-7yoilsho	4147	11	monotherapy	monotherapy	NN
cord-006229-7yoilsho	4147	12	.	.	.
cord-006229-7yoilsho	4148	1	However	however	RB
cord-006229-7yoilsho	4148	2	,	,	,
cord-006229-7yoilsho	4148	3	epilepsy	epilepsy	NN
cord-006229-7yoilsho	4148	4	is	be	VBZ
cord-006229-7yoilsho	4148	5	a	a	DT
cord-006229-7yoilsho	4148	6	complex	complex	JJ
cord-006229-7yoilsho	4148	7	network	network	NN
cord-006229-7yoilsho	4148	8	phenomenon	phenomenon	NN
cord-006229-7yoilsho	4148	9	,	,	,
cord-006229-7yoilsho	4148	10	so	so	IN
cord-006229-7yoilsho	4148	11	that	that	IN
cord-006229-7yoilsho	4148	12	it	-PRON-	PRP
cord-006229-7yoilsho	4148	13	is	be	VBZ
cord-006229-7yoilsho	4148	14	unlikely	unlikely	JJ
cord-006229-7yoilsho	4148	15	that	that	IN
cord-006229-7yoilsho	4148	16	a	a	DT
cord-006229-7yoilsho	4148	17	single	single	JJ
cord-006229-7yoilsho	4148	18	drug	drug	NN
cord-006229-7yoilsho	4148	19	can	can	MD
cord-006229-7yoilsho	4148	20	halt	halt	VB
cord-006229-7yoilsho	4148	21	epileptogenesis	epileptogenesis	NN
cord-006229-7yoilsho	4148	22	.	.	.
cord-006229-7yoilsho	4149	1	Recently	recently	RB
cord-006229-7yoilsho	4149	2	,	,	,
cord-006229-7yoilsho	4149	3	multitargeted	multitargete	VBN
cord-006229-7yoilsho	4149	4	approaches	approach	NNS
cord-006229-7yoilsho	4149	5	were	be	VBD
cord-006229-7yoilsho	4149	6	proposed	propose	VBN
cord-006229-7yoilsho	4149	7	(	(	-LRB-
cord-006229-7yoilsho	4149	8	"	"	``
cord-006229-7yoilsho	4149	9	network	network	NN
cord-006229-7yoilsho	4149	10	pharmacology	pharmacology	NN
cord-006229-7yoilsho	4149	11	"	"	''
cord-006229-7yoilsho	4149	12	)	)	-RRB-
cord-006229-7yoilsho	4149	13	to	to	TO
cord-006229-7yoilsho	4149	14	interfere	interfere	VB
cord-006229-7yoilsho	4149	15	with	with	IN
cord-006229-7yoilsho	4149	16	epileptogenesis	epileptogenesis	NN
cord-006229-7yoilsho	4149	17	.	.	.
cord-006229-7yoilsho	4150	1	Developing	develop	VBG
cord-006229-7yoilsho	4150	2	novel	novel	JJ
cord-006229-7yoilsho	4150	3	combinations	combination	NNS
cord-006229-7yoilsho	4150	4	of	of	IN
cord-006229-7yoilsho	4150	5	clinically	clinically	RB
cord-006229-7yoilsho	4150	6	used	use	VBN
cord-006229-7yoilsho	4150	7	drugs	drug	NNS
cord-006229-7yoilsho	4150	8	with	with	IN
cord-006229-7yoilsho	4150	9	diverse	diverse	JJ
cord-006229-7yoilsho	4150	10	mechanisms	mechanism	NNS
cord-006229-7yoilsho	4150	11	that	that	WDT
cord-006229-7yoilsho	4150	12	are	be	VBP
cord-006229-7yoilsho	4150	13	potentially	potentially	RB
cord-006229-7yoilsho	4150	14	relevant	relevant	JJ
cord-006229-7yoilsho	4150	15	for	for	IN
cord-006229-7yoilsho	4150	16	antiepileptogenesis	antiepileptogenesis	NNP
cord-006229-7yoilsho	4150	17	is	be	VBZ
cord-006229-7yoilsho	4150	18	a	a	DT
cord-006229-7yoilsho	4150	19	strategy	strategy	NN
cord-006229-7yoilsho	4150	20	,	,	,
cord-006229-7yoilsho	4150	21	which	which	WDT
cord-006229-7yoilsho	4150	22	would	would	MD
cord-006229-7yoilsho	4150	23	allow	allow	VB
cord-006229-7yoilsho	4150	24	a	a	DT
cord-006229-7yoilsho	4150	25	relatively	relatively	RB
cord-006229-7yoilsho	4150	26	rapid	rapid	JJ
cord-006229-7yoilsho	4150	27	translation	translation	NN
cord-006229-7yoilsho	4150	28	into	into	IN
cord-006229-7yoilsho	4150	29	the	the	DT
cord-006229-7yoilsho	4150	30	clinic	clinic	NN
cord-006229-7yoilsho	4150	31	.	.	.
cord-006229-7yoilsho	4151	1	We	-PRON-	PRP
cord-006229-7yoilsho	4151	2	developed	develop	VBD
cord-006229-7yoilsho	4151	3	an	an	DT
cord-006229-7yoilsho	4151	4	algorithm	algorithm	NN
cord-006229-7yoilsho	4151	5	for	for	IN
cord-006229-7yoilsho	4151	6	testing	test	VBG
cord-006229-7yoilsho	4151	7	such	such	JJ
cord-006229-7yoilsho	4151	8	drug	drug	NN
cord-006229-7yoilsho	4151	9	combinations	combination	NNS
cord-006229-7yoilsho	4151	10	in	in	IN
cord-006229-7yoilsho	4151	11	a	a	DT
cord-006229-7yoilsho	4151	12	screening	screening	NN
cord-006229-7yoilsho	4151	13	approach	approach	NN
cord-006229-7yoilsho	4151	14	,	,	,
cord-006229-7yoilsho	4151	15	modelled	model	VBN
cord-006229-7yoilsho	4151	16	after	after	IN
cord-006229-7yoilsho	4151	17	the	the	DT
cord-006229-7yoilsho	4151	18	drug	drug	NN
cord-006229-7yoilsho	4151	19	development	development	NN
cord-006229-7yoilsho	4151	20	phases	phase	NNS
cord-006229-7yoilsho	4151	21	in	in	IN
cord-006229-7yoilsho	4151	22	humans	human	NNS
cord-006229-7yoilsho	4151	23	.	.	.
cord-006229-7yoilsho	4152	1	Tolerability	tolerability	NN
cord-006229-7yoilsho	4152	2	of	of	IN
cord-006229-7yoilsho	4152	3	four	four	CD
cord-006229-7yoilsho	4152	4	repeatedly	repeatedly	RB
cord-006229-7yoilsho	4152	5	administered	administer	VBN
cord-006229-7yoilsho	4152	6	drug	drug	NN
cord-006229-7yoilsho	4152	7	combinations	combination	NNS
cord-006229-7yoilsho	4152	8	was	be	VBD
cord-006229-7yoilsho	4152	9	evaluated	evaluate	VBN
cord-006229-7yoilsho	4152	10	by	by	IN
cord-006229-7yoilsho	4152	11	a	a	DT
cord-006229-7yoilsho	4152	12	behavioral	behavioral	JJ
cord-006229-7yoilsho	4152	13	test	test	NN
cord-006229-7yoilsho	4152	14	battery	battery	NN
cord-006229-7yoilsho	4152	15	:	:	:
cord-006229-7yoilsho	4153	1	A	a	DT
cord-006229-7yoilsho	4153	2	,	,	,
cord-006229-7yoilsho	4153	3	levetiracetam	levetiracetam	NNS
cord-006229-7yoilsho	4153	4	and	and	CC
cord-006229-7yoilsho	4153	5	phenobarbital	phenobarbital	NN
cord-006229-7yoilsho	4153	6	;	;	:
cord-006229-7yoilsho	4153	7	B	b	NN
cord-006229-7yoilsho	4153	8	,	,	,
cord-006229-7yoilsho	4153	9	valproate	valproate	RB
cord-006229-7yoilsho	4153	10	,	,	,
cord-006229-7yoilsho	4153	11	losartan	losartan	NNP
cord-006229-7yoilsho	4153	12	,	,	,
cord-006229-7yoilsho	4153	13	and	and	CC
cord-006229-7yoilsho	4153	14	memantine	memantine	NN
cord-006229-7yoilsho	4153	15	;	;	:
cord-006229-7yoilsho	4153	16	C	C	NNP
cord-006229-7yoilsho	4153	17	,	,	,
cord-006229-7yoilsho	4153	18	levetiracetam	levetiracetam	NNP
cord-006229-7yoilsho	4153	19	and	and	CC
cord-006229-7yoilsho	4153	20	topiramate	topiramate	NN
cord-006229-7yoilsho	4153	21	;	;	:
cord-006229-7yoilsho	4153	22	and	and	CC
cord-006229-7yoilsho	4153	23	D	D	NNP
cord-006229-7yoilsho	4153	24	,	,	,
cord-006229-7yoilsho	4153	25	levetiracetam	levetiracetam	NNP
cord-006229-7yoilsho	4153	26	,	,	,
cord-006229-7yoilsho	4153	27	parecoxib	parecoxib	NNP
cord-006229-7yoilsho	4153	28	,	,	,
cord-006229-7yoilsho	4153	29	and	and	CC
cord-006229-7yoilsho	4153	30	anakinra	anakinra	NNP
cord-006229-7yoilsho	4153	31	.	.	.
cord-006229-7yoilsho	4154	1	As	as	IN
cord-006229-7yoilsho	4154	2	in	in	IN
cord-006229-7yoilsho	4154	3	clinical	clinical	JJ
cord-006229-7yoilsho	4154	4	trials	trial	NNS
cord-006229-7yoilsho	4154	5	,	,	,
cord-006229-7yoilsho	4154	6	tolerability	tolerability	NN
cord-006229-7yoilsho	4154	7	was	be	VBD
cord-006229-7yoilsho	4154	8	separately	separately	RB
cord-006229-7yoilsho	4154	9	evaluated	evaluate	VBN
cord-006229-7yoilsho	4154	10	before	before	IN
cord-006229-7yoilsho	4154	11	starting	start	VBG
cord-006229-7yoilsho	4154	12	efficacy	efficacy	NN
cord-006229-7yoilsho	4154	13	experiments	experiment	NNS
cord-006229-7yoilsho	4154	14	to	to	TO
cord-006229-7yoilsho	4154	15	identify	identify	VB
cord-006229-7yoilsho	4154	16	any	any	DT
cord-006229-7yoilsho	4154	17	adverse	adverse	JJ
cord-006229-7yoilsho	4154	18	effects	effect	NNS
cord-006229-7yoilsho	4154	19	of	of	IN
cord-006229-7yoilsho	4154	20	the	the	DT
cord-006229-7yoilsho	4154	21	combinations	combination	NNS
cord-006229-7yoilsho	4154	22	that	that	WDT
cord-006229-7yoilsho	4154	23	may	may	MD
cord-006229-7yoilsho	4154	24	critically	critically	RB
cord-006229-7yoilsho	4154	25	limit	limit	VB
cord-006229-7yoilsho	4154	26	the	the	DT
cord-006229-7yoilsho	4154	27	successful	successful	JJ
cord-006229-7yoilsho	4154	28	use	use	NN
cord-006229-7yoilsho	4154	29	in	in	IN
cord-006229-7yoilsho	4154	30	preclinical	preclinical	JJ
cord-006229-7yoilsho	4154	31	studies	study	NNS
cord-006229-7yoilsho	4154	32	on	on	IN
cord-006229-7yoilsho	4154	33	antiepileptogenesis	antiepileptogenesis	NNP
cord-006229-7yoilsho	4154	34	and	and	CC
cord-006229-7yoilsho	4154	35	translation	translation	NN
cord-006229-7yoilsho	4154	36	of	of	IN
cord-006229-7yoilsho	4154	37	these	these	DT
cord-006229-7yoilsho	4154	38	preclinical	preclinical	JJ
cord-006229-7yoilsho	4154	39	findings	finding	NNS
cord-006229-7yoilsho	4154	40	to	to	IN
cord-006229-7yoilsho	4154	41	the	the	DT
cord-006229-7yoilsho	4154	42	clinic	clinic	NN
cord-006229-7yoilsho	4154	43	.	.	.
cord-006229-7yoilsho	4155	1	Based	base	VBN
cord-006229-7yoilsho	4155	2	on	on	IN
cord-006229-7yoilsho	4155	3	previous	previous	JJ
cord-006229-7yoilsho	4155	4	studies	study	NNS
cord-006229-7yoilsho	4155	5	,	,	,
cord-006229-7yoilsho	4155	6	we	-PRON-	PRP
cord-006229-7yoilsho	4155	7	expected	expect	VBD
cord-006229-7yoilsho	4155	8	that	that	DT
cord-006229-7yoilsho	4155	9	tolerability	tolerability	NN
cord-006229-7yoilsho	4155	10	would	would	MD
cord-006229-7yoilsho	4155	11	be	be	VB
cord-006229-7yoilsho	4155	12	lower	low	JJR
cord-006229-7yoilsho	4155	13	in	in	IN
cord-006229-7yoilsho	4155	14	epileptic	epileptic	JJ
cord-006229-7yoilsho	4155	15	mice	mouse	NNS
cord-006229-7yoilsho	4155	16	than	than	IN
cord-006229-7yoilsho	4155	17	in	in	IN
cord-006229-7yoilsho	4155	18	nonepileptic	nonepileptic	JJ
cord-006229-7yoilsho	4155	19	mice	mouse	NNS
cord-006229-7yoilsho	4155	20	.	.	.
cord-006229-7yoilsho	4156	1	Therefore	therefore	RB
cord-006229-7yoilsho	4156	2	nonepileptic	nonepileptic	JJ
cord-006229-7yoilsho	4156	3	mice	mouse	NNS
cord-006229-7yoilsho	4156	4	were	be	VBD
cord-006229-7yoilsho	4156	5	used	use	VBN
cord-006229-7yoilsho	4156	6	as	as	IN
cord-006229-7yoilsho	4156	7	a	a	DT
cord-006229-7yoilsho	4156	8	first	first	JJ
cord-006229-7yoilsho	4156	9	step	step	NN
cord-006229-7yoilsho	4156	10	,	,	,
cord-006229-7yoilsho	4156	11	followed	follow	VBN
cord-006229-7yoilsho	4156	12	by	by	IN
cord-006229-7yoilsho	4156	13	epileptic	epileptic	JJ
cord-006229-7yoilsho	4156	14	mice	mouse	NNS
cord-006229-7yoilsho	4156	15	and	and	CC
cord-006229-7yoilsho	4156	16	mice	mouse	NNS
cord-006229-7yoilsho	4156	17	during	during	IN
cord-006229-7yoilsho	4156	18	the	the	DT
cord-006229-7yoilsho	4156	19	latent	latent	JJ
cord-006229-7yoilsho	4156	20	period	period	NN
cord-006229-7yoilsho	4156	21	shortly	shortly	RB
cord-006229-7yoilsho	4156	22	after	after	IN
cord-006229-7yoilsho	4156	23	status	status	NN
cord-006229-7yoilsho	4156	24	epilepticus	epilepticus	NN
cord-006229-7yoilsho	4156	25	.	.	.
cord-006229-7yoilsho	4157	1	Except	except	IN
cord-006229-7yoilsho	4157	2	combination	combination	NN
cord-006229-7yoilsho	4157	3	B	b	NN
cord-006229-7yoilsho	4157	4	,	,	,
cord-006229-7yoilsho	4157	5	all	all	DT
cord-006229-7yoilsho	4157	6	drug	drug	NN
cord-006229-7yoilsho	4157	7	cocktails	cocktail	NNS
cord-006229-7yoilsho	4157	8	were	be	VBD
cord-006229-7yoilsho	4157	9	relatively	relatively	RB
cord-006229-7yoilsho	4157	10	well	well	RB
cord-006229-7yoilsho	4157	11	tolerated	tolerate	VBN
cord-006229-7yoilsho	4157	12	.	.	.
cord-006229-7yoilsho	4158	1	In	in	IN
cord-006229-7yoilsho	4158	2	contrast	contrast	NN
cord-006229-7yoilsho	4158	3	to	to	IN
cord-006229-7yoilsho	4158	4	our	-PRON-	PRP$
cord-006229-7yoilsho	4158	5	expectations	expectation	NNS
cord-006229-7yoilsho	4158	6	,	,	,
cord-006229-7yoilsho	4158	7	except	except	IN
cord-006229-7yoilsho	4158	8	combination	combination	NN
cord-006229-7yoilsho	4158	9	C	c	NN
cord-006229-7yoilsho	4158	10	,	,	,
cord-006229-7yoilsho	4158	11	no	no	DT
cord-006229-7yoilsho	4158	12	significant	significant	JJ
cord-006229-7yoilsho	4158	13	differences	difference	NNS
cord-006229-7yoilsho	4158	14	were	be	VBD
cord-006229-7yoilsho	4158	15	determined	determine	VBN
cord-006229-7yoilsho	4158	16	between	between	IN
cord-006229-7yoilsho	4158	17	nonepileptic	nonepileptic	JJ
cord-006229-7yoilsho	4158	18	and	and	CC
cord-006229-7yoilsho	4158	19	post	post	JJ
cord-006229-7yoilsho	4158	20	-	-	NN
cord-006229-7yoilsho	4158	21	status	status	JJ
cord-006229-7yoilsho	4158	22	epilepticus	epilepticus	NN
cord-006229-7yoilsho	4158	23	animals	animal	NNS
cord-006229-7yoilsho	4158	24	.	.	.
cord-006229-7yoilsho	4159	1	As	as	IN
cord-006229-7yoilsho	4159	2	a	a	DT
cord-006229-7yoilsho	4159	3	next	next	JJ
cord-006229-7yoilsho	4159	4	step	step	NN
cord-006229-7yoilsho	4159	5	,	,	,
cord-006229-7yoilsho	4159	6	the	the	DT
cord-006229-7yoilsho	4159	7	rationally	rationally	RB
cord-006229-7yoilsho	4159	8	chosen	choose	VBN
cord-006229-7yoilsho	4159	9	drug	drug	NN
cord-006229-7yoilsho	4159	10	combinations	combination	NNS
cord-006229-7yoilsho	4159	11	will	will	MD
cord-006229-7yoilsho	4159	12	be	be	VB
cord-006229-7yoilsho	4159	13	evaluated	evaluate	VBN
cord-006229-7yoilsho	4159	14	for	for	IN
cord-006229-7yoilsho	4159	15	antiepileptogenic	antiepileptogenic	NNP
cord-006229-7yoilsho	4159	16	activity	activity	NN
cord-006229-7yoilsho	4159	17	in	in	IN
cord-006229-7yoilsho	4159	18	mouse	mouse	NN
cord-006229-7yoilsho	4159	19	and	and	CC
cord-006229-7yoilsho	4159	20	rat	rat	NN
cord-006229-7yoilsho	4159	21	models	model	NNS
cord-006229-7yoilsho	4159	22	of	of	IN
cord-006229-7yoilsho	4159	23	symptomatic	symptomatic	JJ
cord-006229-7yoilsho	4159	24	epilepsy	epilepsy	NN
cord-006229-7yoilsho	4159	25	.	.	.
cord-006229-7yoilsho	4160	1	Major	major	JJ
cord-006229-7yoilsho	4160	2	depression	depression	NN
cord-006229-7yoilsho	4160	3	is	be	VBZ
cord-006229-7yoilsho	4160	4	one	one	CD
cord-006229-7yoilsho	4160	5	of	of	IN
cord-006229-7yoilsho	4160	6	the	the	DT
cord-006229-7yoilsho	4160	7	most	most	RBS
cord-006229-7yoilsho	4160	8	common	common	JJ
cord-006229-7yoilsho	4160	9	mental	mental	JJ
cord-006229-7yoilsho	4160	10	disorders	disorder	NNS
cord-006229-7yoilsho	4160	11	worldwide	worldwide	RB
cord-006229-7yoilsho	4160	12	,	,	,
cord-006229-7yoilsho	4160	13	with	with	IN
cord-006229-7yoilsho	4160	14	serious	serious	JJ
cord-006229-7yoilsho	4160	15	social	social	JJ
cord-006229-7yoilsho	4160	16	and	and	CC
cord-006229-7yoilsho	4160	17	economic	economic	JJ
cord-006229-7yoilsho	4160	18	consequences	consequence	NNS
cord-006229-7yoilsho	4160	19	.	.	.
cord-006229-7yoilsho	4161	1	There	there	EX
cord-006229-7yoilsho	4161	2	are	be	VBP
cord-006229-7yoilsho	4161	3	many	many	JJ
cord-006229-7yoilsho	4161	4	different	different	JJ
cord-006229-7yoilsho	4161	5	hypotheses	hypothesis	NNS
cord-006229-7yoilsho	4161	6	concerning	concern	VBG
cord-006229-7yoilsho	4161	7	the	the	DT
cord-006229-7yoilsho	4161	8	pathophysiology	pathophysiology	NN
cord-006229-7yoilsho	4161	9	of	of	IN
cord-006229-7yoilsho	4161	10	this	this	DT
cord-006229-7yoilsho	4161	11	disease	disease	NN
cord-006229-7yoilsho	4161	12	.	.	.
cord-006229-7yoilsho	4162	1	The	the	DT
cord-006229-7yoilsho	4162	2	complex	complex	JJ
cord-006229-7yoilsho	4162	3	brain	brain	NN
cord-006229-7yoilsho	4162	4	serotonin	serotonin	NN
cord-006229-7yoilsho	4162	5	system	system	NN
cord-006229-7yoilsho	4162	6	and	and	CC
cord-006229-7yoilsho	4162	7	particularly	particularly	RB
cord-006229-7yoilsho	4162	8	the	the	DT
cord-006229-7yoilsho	4162	9	serotonin	serotonin	NN
cord-006229-7yoilsho	4162	10	1A	1A	NNP
cord-006229-7yoilsho	4162	11	receptors	receptor	NNS
cord-006229-7yoilsho	4162	12	(	(	-LRB-
cord-006229-7yoilsho	4162	13	5-HT	5-ht	CD
cord-006229-7yoilsho	4162	14	1A	1a	NN
cord-006229-7yoilsho	4162	15	R	r	NN
cord-006229-7yoilsho	4162	16	)	)	-RRB-
cord-006229-7yoilsho	4162	17	apparently	apparently	RB
cord-006229-7yoilsho	4162	18	play	play	VBP
cord-006229-7yoilsho	4162	19	a	a	DT
cord-006229-7yoilsho	4162	20	pivotal	pivotal	JJ
cord-006229-7yoilsho	4162	21	role	role	NN
cord-006229-7yoilsho	4162	22	in	in	IN
cord-006229-7yoilsho	4162	23	the	the	DT
cord-006229-7yoilsho	4162	24	development	development	NN
cord-006229-7yoilsho	4162	25	of	of	IN
cord-006229-7yoilsho	4162	26	depression	depression	NN
cord-006229-7yoilsho	4162	27	.	.	.
cord-006229-7yoilsho	4163	1	The	the	DT
cord-006229-7yoilsho	4163	2	involvement	involvement	NN
cord-006229-7yoilsho	4163	3	of	of	IN
cord-006229-7yoilsho	4163	4	an	an	DT
cord-006229-7yoilsho	4163	5	altered	altered	JJ
cord-006229-7yoilsho	4163	6	,	,	,
cord-006229-7yoilsho	4163	7	5-HT	5-ht	CD
cord-006229-7yoilsho	4163	8	1A	1a	NN
cord-006229-7yoilsho	4163	9	R	r	NN
cord-006229-7yoilsho	4163	10	-	-	HYPH
cord-006229-7yoilsho	4163	11	mediated	mediate	VBN
cord-006229-7yoilsho	4163	12	signalling	signalling	NN
cord-006229-7yoilsho	4163	13	in	in	IN
cord-006229-7yoilsho	4163	14	adult	adult	NN
cord-006229-7yoilsho	4163	15	neurogenesis	neurogenesis	NN
cord-006229-7yoilsho	4163	16	is	be	VBZ
cord-006229-7yoilsho	4163	17	also	also	RB
cord-006229-7yoilsho	4163	18	discussed	discuss	VBN
cord-006229-7yoilsho	4163	19	.	.	.
cord-006229-7yoilsho	4164	1	However	however	RB
cord-006229-7yoilsho	4164	2	,	,	,
cord-006229-7yoilsho	4164	3	in	in	IN
cord-006229-7yoilsho	4164	4	this	this	DT
cord-006229-7yoilsho	4164	5	context	context	NN
cord-006229-7yoilsho	4164	6	the	the	DT
cord-006229-7yoilsho	4164	7	effects	effect	NNS
cord-006229-7yoilsho	4164	8	of	of	IN
cord-006229-7yoilsho	4164	9	pre	pre	JJ
cord-006229-7yoilsho	4164	10	-	-	JJ
cord-006229-7yoilsho	4164	11	and	and	CC
cord-006229-7yoilsho	4164	12	postsynaptically	postsynaptically	RB
cord-006229-7yoilsho	4164	13	located	locate	VBN
cord-006229-7yoilsho	4164	14	5-HT	5-ht	CD
cord-006229-7yoilsho	4164	15	1A	1a	CD
cord-006229-7yoilsho	4165	1	Rs	r	NNS
cord-006229-7yoilsho	4165	2	have	have	VBP
cord-006229-7yoilsho	4165	3	not	not	RB
cord-006229-7yoilsho	4165	4	been	be	VBN
cord-006229-7yoilsho	4165	5	clarified	clarify	VBN
cord-006229-7yoilsho	4165	6	yet	yet	RB
cord-006229-7yoilsho	4165	7	.	.	.
cord-006229-7yoilsho	4166	1	Mice	mouse	NNS
cord-006229-7yoilsho	4166	2	with	with	IN
cord-006229-7yoilsho	4166	3	a	a	DT
cord-006229-7yoilsho	4166	4	permanent	permanent	JJ
cord-006229-7yoilsho	4166	5	overexpression	overexpression	NN
cord-006229-7yoilsho	4166	6	of	of	IN
cord-006229-7yoilsho	4166	7	postsynaptic	postsynaptic	JJ
cord-006229-7yoilsho	4166	8	5-HT	5-ht	CD
cord-006229-7yoilsho	4166	9	1A	1a	NN
cord-006229-7yoilsho	4166	10	Rs	r	NNS
cord-006229-7yoilsho	4166	11	(	(	-LRB-
cord-006229-7yoilsho	4166	12	OE	OE	NNP
cord-006229-7yoilsho	4166	13	mice	mouse	NNS
cord-006229-7yoilsho	4166	14	)	)	-RRB-
cord-006229-7yoilsho	4166	15	represent	represent	VBP
cord-006229-7yoilsho	4166	16	a	a	DT
cord-006229-7yoilsho	4166	17	unique	unique	JJ
cord-006229-7yoilsho	4166	18	tool	tool	NN
cord-006229-7yoilsho	4166	19	to	to	TO
cord-006229-7yoilsho	4166	20	elucidate	elucidate	VB
cord-006229-7yoilsho	4166	21	the	the	DT
cord-006229-7yoilsho	4166	22	effects	effect	NNS
cord-006229-7yoilsho	4166	23	of	of	IN
cord-006229-7yoilsho	4166	24	postsynaptic	postsynaptic	JJ
cord-006229-7yoilsho	4166	25	5-HT	5-ht	CD
cord-006229-7yoilsho	4166	26	1A	1a	NN
cord-006229-7yoilsho	4166	27	Rs	r	NNS
cord-006229-7yoilsho	4166	28	in	in	IN
cord-006229-7yoilsho	4166	29	adult	adult	NN
cord-006229-7yoilsho	4166	30	neurogenesis	neurogenesis	NN
cord-006229-7yoilsho	4166	31	and	and	CC
cord-006229-7yoilsho	4166	32	depressive	depressive	JJ
cord-006229-7yoilsho	4166	33	-	-	HYPH
cord-006229-7yoilsho	4166	34	like	like	JJ
cord-006229-7yoilsho	4166	35	behaviour	behaviour	NN
cord-006229-7yoilsho	4166	36	.	.	.
cord-006229-7yoilsho	4167	1	Previous	previous	JJ
cord-006229-7yoilsho	4167	2	studies	study	NNS
cord-006229-7yoilsho	4167	3	demonstrated	demonstrate	VBD
cord-006229-7yoilsho	4167	4	an	an	DT
cord-006229-7yoilsho	4167	5	increased	increase	VBN
cord-006229-7yoilsho	4167	6	proliferation	proliferation	NN
cord-006229-7yoilsho	4167	7	and	and	CC
cord-006229-7yoilsho	4167	8	survival	survival	NN
cord-006229-7yoilsho	4167	9	of	of	IN
cord-006229-7yoilsho	4167	10	newborn	newborn	JJ
cord-006229-7yoilsho	4167	11	cells	cell	NNS
cord-006229-7yoilsho	4167	12	in	in	IN
cord-006229-7yoilsho	4167	13	the	the	DT
cord-006229-7yoilsho	4167	14	adult	adult	NN
cord-006229-7yoilsho	4167	15	dentate	dentate	NN
cord-006229-7yoilsho	4167	16	gyrus	gyrus	NN
cord-006229-7yoilsho	4167	17	of	of	IN
cord-006229-7yoilsho	4167	18	female	female	JJ
cord-006229-7yoilsho	4167	19	OE	OE	NNP
cord-006229-7yoilsho	4167	20	mice	mouse	NNS
cord-006229-7yoilsho	4167	21	in	in	IN
cord-006229-7yoilsho	4167	22	comparison	comparison	NN
cord-006229-7yoilsho	4167	23	to	to	IN
cord-006229-7yoilsho	4167	24	controls	control	NNS
cord-006229-7yoilsho	4167	25	.	.	.
cord-006229-7yoilsho	4168	1	In	in	IN
cord-006229-7yoilsho	4168	2	the	the	DT
cord-006229-7yoilsho	4168	3	present	present	JJ
cord-006229-7yoilsho	4168	4	study	study	NN
cord-006229-7yoilsho	4168	5	,	,	,
cord-006229-7yoilsho	4168	6	we	-PRON-	PRP
cord-006229-7yoilsho	4168	7	investigate	investigate	VBP
cord-006229-7yoilsho	4168	8	the	the	DT
cord-006229-7yoilsho	4168	9	proliferation	proliferation	NN
cord-006229-7yoilsho	4168	10	and	and	CC
cord-006229-7yoilsho	4168	11	survival	survival	NN
cord-006229-7yoilsho	4168	12	of	of	IN
cord-006229-7yoilsho	4168	13	adult	adult	NN
cord-006229-7yoilsho	4168	14	born	bear	VBN
cord-006229-7yoilsho	4168	15	cells	cell	NNS
cord-006229-7yoilsho	4168	16	after	after	IN
cord-006229-7yoilsho	4168	17	chronic	chronic	JJ
cord-006229-7yoilsho	4168	18	treatment	treatment	NN
cord-006229-7yoilsho	4168	19	(	(	-LRB-
cord-006229-7yoilsho	4168	20	15	15	CD
cord-006229-7yoilsho	4168	21	days	day	NNS
cord-006229-7yoilsho	4168	22	)	)	-RRB-
cord-006229-7yoilsho	4168	23	with	with	IN
cord-006229-7yoilsho	4168	24	the	the	DT
cord-006229-7yoilsho	4168	25	selective	selective	JJ
cord-006229-7yoilsho	4168	26	5-HT	5-ht	CD
cord-006229-7yoilsho	4168	27	1A	1a	NN
cord-006229-7yoilsho	4168	28	R	r	NN
cord-006229-7yoilsho	4168	29	agonist	agonist	NN
cord-006229-7yoilsho	4168	30	8-OH	8-oh	CD
cord-006229-7yoilsho	4168	31	-	-	HYPH
cord-006229-7yoilsho	4168	32	DPAT	dpat	NN
cord-006229-7yoilsho	4169	1	(	(	-LRB-
cord-006229-7yoilsho	4169	2	0,5	0,5	CD
cord-006229-7yoilsho	4169	3	mg	mg	NNP
cord-006229-7yoilsho	4169	4	/	/	SYM
cord-006229-7yoilsho	4169	5	kg	kg	NNP
cord-006229-7yoilsho	4169	6	/	/	SYM
cord-006229-7yoilsho	4169	7	day	day	NN
cord-006229-7yoilsho	4169	8	)	)	-RRB-
cord-006229-7yoilsho	4169	9	in	in	IN
cord-006229-7yoilsho	4169	10	young	young	JJ
cord-006229-7yoilsho	4169	11	adult	adult	NN
cord-006229-7yoilsho	4169	12	OE	OE	NNP
cord-006229-7yoilsho	4169	13	and	and	CC
cord-006229-7yoilsho	4169	14	WT	WT	NNP
cord-006229-7yoilsho	4169	15	mice	mouse	NNS
cord-006229-7yoilsho	4169	16	.	.	.
cord-006229-7yoilsho	4170	1	On	on	IN
cord-006229-7yoilsho	4170	2	the	the	DT
cord-006229-7yoilsho	4170	3	last	last	JJ
cord-006229-7yoilsho	4170	4	three	three	CD
cord-006229-7yoilsho	4170	5	days	day	NNS
cord-006229-7yoilsho	4170	6	of	of	IN
cord-006229-7yoilsho	4170	7	treatment	treatment	NN
cord-006229-7yoilsho	4170	8	,	,	,
cord-006229-7yoilsho	4170	9	newly	newly	RB
cord-006229-7yoilsho	4170	10	generated	generate	VBN
cord-006229-7yoilsho	4170	11	cells	cell	NNS
cord-006229-7yoilsho	4170	12	of	of	IN
cord-006229-7yoilsho	4170	13	OE	OE	NNP
cord-006229-7yoilsho	4170	14	and	and	CC
cord-006229-7yoilsho	4170	15	WT	WT	NNP
cord-006229-7yoilsho	4170	16	mice	mouse	NNS
cord-006229-7yoilsho	4170	17	are	be	VBP
cord-006229-7yoilsho	4170	18	labelled	label	VBN
cord-006229-7yoilsho	4170	19	by	by	IN
cord-006229-7yoilsho	4170	20	injections	injection	NNS
cord-006229-7yoilsho	4170	21	with	with	IN
cord-006229-7yoilsho	4170	22	bromodeoxyuridine	bromodeoxyuridine	NN
cord-006229-7yoilsho	4170	23	(	(	-LRB-
cord-006229-7yoilsho	4170	24	BrdU	BrdU	NNP
cord-006229-7yoilsho	4170	25	;	;	:
cord-006229-7yoilsho	4170	26	50	50	CD
cord-006229-7yoilsho	4170	27	mg	mg	NNP
cord-006229-7yoilsho	4170	28	/	/	SYM
cord-006229-7yoilsho	4170	29	kg	kg	NNP
cord-006229-7yoilsho	4170	30	/	/	SYM
cord-006229-7yoilsho	4170	31	day	day	NN
cord-006229-7yoilsho	4170	32	)	)	-RRB-
cord-006229-7yoilsho	4170	33	.	.	.
cord-006229-7yoilsho	4171	1	Mice	mouse	NNS
cord-006229-7yoilsho	4171	2	are	be	VBP
cord-006229-7yoilsho	4171	3	sacrificed	sacrifice	VBN
cord-006229-7yoilsho	4171	4	either	either	CC
cord-006229-7yoilsho	4171	5	one	one	CD
cord-006229-7yoilsho	4171	6	day	day	NN
cord-006229-7yoilsho	4171	7	(	(	-LRB-
cord-006229-7yoilsho	4171	8	proliferation	proliferation	NN
cord-006229-7yoilsho	4171	9	)	)	-RRB-
cord-006229-7yoilsho	4171	10	or	or	CC
cord-006229-7yoilsho	4171	11	21	21	CD
cord-006229-7yoilsho	4171	12	days	day	NNS
cord-006229-7yoilsho	4171	13	(	(	-LRB-
cord-006229-7yoilsho	4171	14	survival	survival	NN
cord-006229-7yoilsho	4171	15	)	)	-RRB-
cord-006229-7yoilsho	4171	16	after	after	IN
cord-006229-7yoilsho	4171	17	the	the	DT
cord-006229-7yoilsho	4171	18	last	last	JJ
cord-006229-7yoilsho	4171	19	injection	injection	NN
cord-006229-7yoilsho	4171	20	.	.	.
cord-006229-7yoilsho	4172	1	We	-PRON-	PRP
cord-006229-7yoilsho	4172	2	hypothesise	hypothesise	VBP
cord-006229-7yoilsho	4172	3	that	that	IN
cord-006229-7yoilsho	4172	4	the	the	DT
cord-006229-7yoilsho	4172	5	data	datum	NNS
cord-006229-7yoilsho	4172	6	we	-PRON-	PRP
cord-006229-7yoilsho	4172	7	will	will	MD
cord-006229-7yoilsho	4172	8	present	present	VB
cord-006229-7yoilsho	4172	9	will	will	MD
cord-006229-7yoilsho	4172	10	confirm	confirm	VB
cord-006229-7yoilsho	4172	11	our	-PRON-	PRP$
cord-006229-7yoilsho	4172	12	previous	previous	JJ
cord-006229-7yoilsho	4172	13	results	result	NNS
cord-006229-7yoilsho	4172	14	,	,	,
cord-006229-7yoilsho	4172	15	with	with	IN
cord-006229-7yoilsho	4172	16	possibly	possibly	RB
cord-006229-7yoilsho	4172	17	more	more	RBR
cord-006229-7yoilsho	4172	18	pronounced	pronounce	VBN
cord-006229-7yoilsho	4172	19	proneurogenic	proneurogenic	JJ
cord-006229-7yoilsho	4172	20	effects	effect	NNS
cord-006229-7yoilsho	4172	21	and	and	CC
cord-006229-7yoilsho	4172	22	differences	difference	NNS
cord-006229-7yoilsho	4172	23	in	in	IN
cord-006229-7yoilsho	4172	24	male	male	JJ
cord-006229-7yoilsho	4172	25	mice	mouse	NNS
cord-006229-7yoilsho	4172	26	.	.	.
cord-006229-7yoilsho	4173	1	Further	further	JJ
cord-006229-7yoilsho	4173	2	immunohistochemical	immunohistochemical	JJ
cord-006229-7yoilsho	4173	3	studies	study	NNS
cord-006229-7yoilsho	4173	4	post	post	NN
cord-006229-7yoilsho	4173	5	-	-	NN
cord-006229-7yoilsho	4173	6	exercise	exercise	JJ
cord-006229-7yoilsho	4173	7	and	and	CC
cord-006229-7yoilsho	4173	8	behavioural	behavioural	JJ
cord-006229-7yoilsho	4173	9	analyses	analysis	NNS
cord-006229-7yoilsho	4173	10	are	be	VBP
cord-006229-7yoilsho	4173	11	in	in	IN
cord-006229-7yoilsho	4173	12	progress	progress	NN
cord-006229-7yoilsho	4173	13	to	to	TO
cord-006229-7yoilsho	4173	14	identify	identify	VB
cord-006229-7yoilsho	4173	15	the	the	DT
cord-006229-7yoilsho	4173	16	relation	relation	NN
cord-006229-7yoilsho	4173	17	between	between	IN
cord-006229-7yoilsho	4173	18	chronic	chronic	JJ
cord-006229-7yoilsho	4173	19	postsynaptic	postsynaptic	JJ
cord-006229-7yoilsho	4173	20	5-HT	5-ht	CD
cord-006229-7yoilsho	4173	21	1A	1a	NN
cord-006229-7yoilsho	4173	22	R	r	NN
cord-006229-7yoilsho	4173	23	stimulation	stimulation	NN
cord-006229-7yoilsho	4173	24	,	,	,
cord-006229-7yoilsho	4173	25	depressive	depressive	JJ
cord-006229-7yoilsho	4173	26	-	-	HYPH
cord-006229-7yoilsho	4173	27	like	like	JJ
cord-006229-7yoilsho	4173	28	behaviour	behaviour	NN
cord-006229-7yoilsho	4173	29	and	and	CC
cord-006229-7yoilsho	4173	30	hippocampusdependent	hippocampusdependent	NN
cord-006229-7yoilsho	4173	31	learning	learning	NN
cord-006229-7yoilsho	4173	32	.	.	.
cord-006229-7yoilsho	4174	1	Dystonia	Dystonia	NNP
cord-006229-7yoilsho	4174	2	is	be	VBZ
cord-006229-7yoilsho	4174	3	a	a	DT
cord-006229-7yoilsho	4174	4	common	common	JJ
cord-006229-7yoilsho	4174	5	movement	movement	NN
cord-006229-7yoilsho	4174	6	disorder	disorder	NN
cord-006229-7yoilsho	4174	7	characterized	characterize	VBN
cord-006229-7yoilsho	4174	8	by	by	IN
cord-006229-7yoilsho	4174	9	intermittent	intermittent	JJ
cord-006229-7yoilsho	4174	10	and	and	CC
cord-006229-7yoilsho	4174	11	prolonged	prolonged	JJ
cord-006229-7yoilsho	4174	12	muscle	muscle	NN
cord-006229-7yoilsho	4174	13	contractions	contraction	NNS
cord-006229-7yoilsho	4174	14	resulting	result	VBG
cord-006229-7yoilsho	4174	15	in	in	IN
cord-006229-7yoilsho	4174	16	involuntary	involuntary	JJ
cord-006229-7yoilsho	4174	17	movements	movement	NNS
cord-006229-7yoilsho	4174	18	and/or	and/or	CC
cord-006229-7yoilsho	4174	19	abnormal	abnormal	JJ
cord-006229-7yoilsho	4174	20	postures	posture	NNS
cord-006229-7yoilsho	4174	21	.	.	.
cord-006229-7yoilsho	4175	1	The	the	DT
cord-006229-7yoilsho	4175	2	lack	lack	NN
cord-006229-7yoilsho	4175	3	of	of	IN
cord-006229-7yoilsho	4175	4	knowledge	knowledge	NN
cord-006229-7yoilsho	4175	5	of	of	IN
cord-006229-7yoilsho	4175	6	the	the	DT
cord-006229-7yoilsho	4175	7	pathophysiology	pathophysiology	NN
cord-006229-7yoilsho	4175	8	of	of	IN
cord-006229-7yoilsho	4175	9	dystonia	dystonia	NN
cord-006229-7yoilsho	4175	10	hampers	hamper	VBZ
cord-006229-7yoilsho	4175	11	the	the	DT
cord-006229-7yoilsho	4175	12	development	development	NN
cord-006229-7yoilsho	4175	13	of	of	IN
cord-006229-7yoilsho	4175	14	effective	effective	JJ
cord-006229-7yoilsho	4175	15	therapeutics	therapeutic	NNS
cord-006229-7yoilsho	4175	16	.	.	.
cord-006229-7yoilsho	4176	1	Although	although	IN
cord-006229-7yoilsho	4176	2	benzodiazepines	benzodiazepine	NNS
cord-006229-7yoilsho	4176	3	can	can	MD
cord-006229-7yoilsho	4176	4	improve	improve	VB
cord-006229-7yoilsho	4176	5	dystonic	dystonic	JJ
cord-006229-7yoilsho	4176	6	symptoms	symptom	NNS
cord-006229-7yoilsho	4176	7	,	,	,
cord-006229-7yoilsho	4176	8	tolerance	tolerance	NN
cord-006229-7yoilsho	4176	9	and	and	CC
cord-006229-7yoilsho	4176	10	side	side	NN
cord-006229-7yoilsho	4176	11	effects	effect	NNS
cord-006229-7yoilsho	4176	12	limit	limit	VBP
cord-006229-7yoilsho	4176	13	their	-PRON-	PRP$
cord-006229-7yoilsho	4176	14	use	use	NN
cord-006229-7yoilsho	4176	15	.	.	.
cord-006229-7yoilsho	4177	1	There	there	EX
cord-006229-7yoilsho	4177	2	is	be	VBZ
cord-006229-7yoilsho	4177	3	evidence	evidence	NN
cord-006229-7yoilsho	4177	4	for	for	IN
cord-006229-7yoilsho	4177	5	striatal	striatal	JJ
cord-006229-7yoilsho	4177	6	dysfunctions	dysfunction	NNS
cord-006229-7yoilsho	4177	7	in	in	IN
cord-006229-7yoilsho	4177	8	human	human	JJ
cord-006229-7yoilsho	4177	9	dystonia	dystonia	NN
cord-006229-7yoilsho	4177	10	.	.	.
cord-006229-7yoilsho	4178	1	GABAergic	GABAergic	NNP
cord-006229-7yoilsho	4178	2	striatal	striatal	JJ
cord-006229-7yoilsho	4178	3	interneurons	interneuron	NNS
cord-006229-7yoilsho	4178	4	(	(	-LRB-
cord-006229-7yoilsho	4178	5	IN	in	IN
cord-006229-7yoilsho	4178	6	)	)	-RRB-
cord-006229-7yoilsho	4178	7	are	be	VBP
cord-006229-7yoilsho	4178	8	important	important	JJ
cord-006229-7yoilsho	4178	9	for	for	IN
cord-006229-7yoilsho	4178	10	the	the	DT
cord-006229-7yoilsho	4178	11	regulation	regulation	NN
cord-006229-7yoilsho	4178	12	of	of	IN
cord-006229-7yoilsho	4178	13	striatal	striatal	JJ
cord-006229-7yoilsho	4178	14	signaling	signaling	NN
cord-006229-7yoilsho	4178	15	.	.	.
cord-006229-7yoilsho	4179	1	In	in	IN
cord-006229-7yoilsho	4179	2	the	the	DT
cord-006229-7yoilsho	4179	3	dt	dt	NN
cord-006229-7yoilsho	4179	4	sz	sz	NNP
cord-006229-7yoilsho	4179	5	mutant	mutant	JJ
cord-006229-7yoilsho	4179	6	hamster	hamster	NN
cord-006229-7yoilsho	4179	7	,	,	,
cord-006229-7yoilsho	4179	8	a	a	DT
cord-006229-7yoilsho	4179	9	model	model	NN
cord-006229-7yoilsho	4179	10	of	of	IN
cord-006229-7yoilsho	4179	11	paroxysmal	paroxysmal	JJ
cord-006229-7yoilsho	4179	12	dystonia	dystonia	NN
cord-006229-7yoilsho	4179	13	,	,	,
cord-006229-7yoilsho	4179	14	immunoreactive	immunoreactive	NNP
cord-006229-7yoilsho	4179	15	IN	in	IN
cord-006229-7yoilsho	4179	16	were	be	VBD
cord-006229-7yoilsho	4179	17	reduced	reduce	VBN
cord-006229-7yoilsho	4179	18	at	at	IN
cord-006229-7yoilsho	4179	19	the	the	DT
cord-006229-7yoilsho	4179	20	age	age	NN
cord-006229-7yoilsho	4179	21	of	of	IN
cord-006229-7yoilsho	4179	22	maximum	maximum	JJ
cord-006229-7yoilsho	4179	23	severity	severity	NN
cord-006229-7yoilsho	4179	24	of	of	IN
cord-006229-7yoilsho	4179	25	dystonia	dystonia	NN
cord-006229-7yoilsho	4179	26	(	(	-LRB-
cord-006229-7yoilsho	4179	27	33	33	CD
cord-006229-7yoilsho	4179	28	days	day	NNS
cord-006229-7yoilsho	4179	29	)	)	-RRB-
cord-006229-7yoilsho	4179	30	,	,	,
cord-006229-7yoilsho	4179	31	but	but	CC
cord-006229-7yoilsho	4179	32	not	not	RB
cord-006229-7yoilsho	4179	33	after	after	IN
cord-006229-7yoilsho	4179	34	spontaneous	spontaneous	JJ
cord-006229-7yoilsho	4179	35	remission	remission	NN
cord-006229-7yoilsho	4179	36	(	(	-LRB-
cord-006229-7yoilsho	4179	37	age	age	NN
cord-006229-7yoilsho	4179	38	90	90	CD
cord-006229-7yoilsho	4179	39	days	day	NNS
cord-006229-7yoilsho	4179	40	)	)	-RRB-
cord-006229-7yoilsho	4179	41	.	.	.
cord-006229-7yoilsho	4180	1	As	as	IN
cord-006229-7yoilsho	4180	2	indicated	indicate	VBN
cord-006229-7yoilsho	4180	3	by	by	IN
cord-006229-7yoilsho	4180	4	unaltered	unaltered	JJ
cord-006229-7yoilsho	4180	5	homeoboxprotein	homeoboxprotein	NNP
cord-006229-7yoilsho	4180	6	nkx	nkx	NNP
cord-006229-7yoilsho	4180	7	2.1	2.1	CD
cord-006229-7yoilsho	4180	8	(	(	-LRB-
cord-006229-7yoilsho	4180	9	cell	cell	NN
cord-006229-7yoilsho	4180	10	density	density	NN
cord-006229-7yoilsho	4180	11	,	,	,
cord-006229-7yoilsho	4180	12	mRNA	mRNA	NNP
cord-006229-7yoilsho	4180	13	)	)	-RRB-
cord-006229-7yoilsho	4180	14	,	,	,
cord-006229-7yoilsho	4180	15	the	the	DT
cord-006229-7yoilsho	4180	16	age	age	NN
cord-006229-7yoilsho	4180	17	-	-	HYPH
cord-006229-7yoilsho	4180	18	dependent	dependent	JJ
cord-006229-7yoilsho	4180	19	deficit	deficit	NN
cord-006229-7yoilsho	4180	20	seems	seem	VBZ
cord-006229-7yoilsho	4180	21	not	not	RB
cord-006229-7yoilsho	4180	22	to	to	TO
cord-006229-7yoilsho	4180	23	be	be	VB
cord-006229-7yoilsho	4180	24	related	relate	VBN
cord-006229-7yoilsho	4180	25	to	to	IN
cord-006229-7yoilsho	4180	26	a	a	DT
cord-006229-7yoilsho	4180	27	disturbed	disturbed	JJ
cord-006229-7yoilsho	4180	28	migration	migration	NN
cord-006229-7yoilsho	4180	29	,	,	,
cord-006229-7yoilsho	4180	30	but	but	CC
cord-006229-7yoilsho	4180	31	to	to	IN
cord-006229-7yoilsho	4180	32	a	a	DT
cord-006229-7yoilsho	4180	33	retarded	retarded	JJ
cord-006229-7yoilsho	4180	34	maturation	maturation	NN
cord-006229-7yoilsho	4180	35	of	of	IN
cord-006229-7yoilsho	4180	36	IN	in	NN
cord-006229-7yoilsho	4180	37	in	in	IN
cord-006229-7yoilsho	4180	38	mutant	mutant	JJ
cord-006229-7yoilsho	4180	39	hamsters	hamster	NNS
cord-006229-7yoilsho	4180	40	.	.	.
cord-006229-7yoilsho	4181	1	Here	here	RB
cord-006229-7yoilsho	4181	2	we	-PRON-	PRP
cord-006229-7yoilsho	4181	3	further	further	RB
cord-006229-7yoilsho	4181	4	determined	determine	VBD
cord-006229-7yoilsho	4181	5	the	the	DT
cord-006229-7yoilsho	4181	6	maturation	maturation	NN
cord-006229-7yoilsho	4181	7	of	of	IN
cord-006229-7yoilsho	4181	8	striatal	striatal	JJ
cord-006229-7yoilsho	4181	9	GABAergic	GABAergic	NNP
cord-006229-7yoilsho	4181	10	neurons	neuron	NNS
cord-006229-7yoilsho	4181	11	in	in	IN
cord-006229-7yoilsho	4181	12	the	the	DT
cord-006229-7yoilsho	4181	13	dt	dt	NN
cord-006229-7yoilsho	4181	14	sz	sz	NN
cord-006229-7yoilsho	4181	15	hamster	hamster	NN
cord-006229-7yoilsho	4181	16	compared	compare	VBN
cord-006229-7yoilsho	4181	17	to	to	IN
cord-006229-7yoilsho	4181	18	healthy	healthy	JJ
cord-006229-7yoilsho	4181	19	controls	control	NNS
cord-006229-7yoilsho	4181	20	.	.	.
cord-006229-7yoilsho	4182	1	KCC2	KCC2	NNP
cord-006229-7yoilsho	4182	2	and	and	CC
cord-006229-7yoilsho	4182	3	CAVII	CAVII	NNP
cord-006229-7yoilsho	4182	4	mRNA	mRNA	NNP
cord-006229-7yoilsho	4182	5	,	,	,
cord-006229-7yoilsho	4182	6	used	use	VBN
cord-006229-7yoilsho	4182	7	as	as	IN
cord-006229-7yoilsho	4182	8	markers	marker	NNS
cord-006229-7yoilsho	4182	9	for	for	IN
cord-006229-7yoilsho	4182	10	the	the	DT
cord-006229-7yoilsho	4182	11	GABA	GABA	NNP
cord-006229-7yoilsho	4182	12	-	-	HYPH
cord-006229-7yoilsho	4182	13	switch	switch	NN
cord-006229-7yoilsho	4182	14	,	,	,
cord-006229-7yoilsho	4182	15	were	be	VBD
cord-006229-7yoilsho	4182	16	unchanged	unchanged	JJ
cord-006229-7yoilsho	4182	17	in	in	IN
cord-006229-7yoilsho	4182	18	18	18	CD
cord-006229-7yoilsho	4182	19	and	and	CC
cord-006229-7yoilsho	4182	20	33	33	CD
cord-006229-7yoilsho	4182	21	day	day	NN
cord-006229-7yoilsho	4182	22	old	old	JJ
cord-006229-7yoilsho	4182	23	mutant	mutant	JJ
cord-006229-7yoilsho	4182	24	hamsters	hamster	NNS
cord-006229-7yoilsho	4182	25	,	,	,
cord-006229-7yoilsho	4182	26	indicating	indicate	VBG
cord-006229-7yoilsho	4182	27	that	that	IN
cord-006229-7yoilsho	4182	28	there	there	EX
cord-006229-7yoilsho	4182	29	is	be	VBZ
cord-006229-7yoilsho	4182	30	no	no	DT
cord-006229-7yoilsho	4182	31	general	general	JJ
cord-006229-7yoilsho	4182	32	delay	delay	NN
cord-006229-7yoilsho	4182	33	in	in	IN
cord-006229-7yoilsho	4182	34	GABAergic	GABAergic	NNP
cord-006229-7yoilsho	4182	35	maturation	maturation	NN
cord-006229-7yoilsho	4182	36	.	.	.
cord-006229-7yoilsho	4183	1	As	as	IN
cord-006229-7yoilsho	4183	2	a	a	DT
cord-006229-7yoilsho	4183	3	retarded	retarded	JJ
cord-006229-7yoilsho	4183	4	maturation	maturation	NN
cord-006229-7yoilsho	4183	5	seems	seem	VBZ
cord-006229-7yoilsho	4183	6	to	to	TO
cord-006229-7yoilsho	4183	7	be	be	VB
cord-006229-7yoilsho	4183	8	specific	specific	JJ
cord-006229-7yoilsho	4183	9	for	for	IN
cord-006229-7yoilsho	4183	10	IN	in	RB
cord-006229-7yoilsho	4183	11	,	,	,
cord-006229-7yoilsho	4183	12	we	-PRON-	PRP
cord-006229-7yoilsho	4183	13	used	use	VBD
cord-006229-7yoilsho	4183	14	another	another	DT
cord-006229-7yoilsho	4183	15	marker	marker	NN
cord-006229-7yoilsho	4183	16	for	for	IN
cord-006229-7yoilsho	4183	17	GABAergic	GABAergic	NNP
cord-006229-7yoilsho	4183	18	maturation	maturation	NN
cord-006229-7yoilsho	4183	19	:	:	:
cord-006229-7yoilsho	4183	20	the	the	DT
cord-006229-7yoilsho	4183	21	expression	expression	NN
cord-006229-7yoilsho	4183	22	of	of	IN
cord-006229-7yoilsho	4183	23	specific	specific	JJ
cord-006229-7yoilsho	4183	24	GABA	GABA	NNP
cord-006229-7yoilsho	4183	25	A	a	DT
cord-006229-7yoilsho	4183	26	receptor	receptor	NN
cord-006229-7yoilsho	4183	27	(	(	-LRB-
cord-006229-7yoilsho	4183	28	GABA	GABA	NNP
cord-006229-7yoilsho	4183	29	A	A	NNP
cord-006229-7yoilsho	4183	30	R	r	NN
cord-006229-7yoilsho	4183	31	)	)	-RRB-
cord-006229-7yoilsho	4183	32	subunits	subunit	NNS
cord-006229-7yoilsho	4183	33	(	(	-LRB-
cord-006229-7yoilsho	4183	34	mature	mature	VBP
cord-006229-7yoilsho	4183	35	striatal	striatal	JJ
cord-006229-7yoilsho	4183	36	IN	in	IN
cord-006229-7yoilsho	4183	37	express	express	NN
cord-006229-7yoilsho	4183	38	the	the	DT
cord-006229-7yoilsho	4183	39	alpha1	alpha1	NN
cord-006229-7yoilsho	4183	40	subunit	subunit	NN
cord-006229-7yoilsho	4183	41	)	)	-RRB-
cord-006229-7yoilsho	4183	42	.	.	.
cord-006229-7yoilsho	4184	1	By	by	IN
cord-006229-7yoilsho	4184	2	stereological	stereological	JJ
cord-006229-7yoilsho	4184	3	determination	determination	NN
cord-006229-7yoilsho	4184	4	,	,	,
cord-006229-7yoilsho	4184	5	we	-PRON-	PRP
cord-006229-7yoilsho	4184	6	found	find	VBD
cord-006229-7yoilsho	4184	7	a	a	DT
cord-006229-7yoilsho	4184	8	46	46	CD
cord-006229-7yoilsho	4184	9	%	%	NN
cord-006229-7yoilsho	4184	10	decrease	decrease	NN
cord-006229-7yoilsho	4184	11	in	in	IN
cord-006229-7yoilsho	4184	12	alpha1	alpha1	NN
cord-006229-7yoilsho	4184	13	subunit	subunit	NN
cord-006229-7yoilsho	4184	14	expressing	express	VBG
cord-006229-7yoilsho	4184	15	neurons	neuron	NNS
cord-006229-7yoilsho	4184	16	.	.	.
cord-006229-7yoilsho	4185	1	A	a	DT
cord-006229-7yoilsho	4185	2	lower	low	JJR
cord-006229-7yoilsho	4185	3	immunoreactive	immunoreactive	JJ
cord-006229-7yoilsho	4185	4	intensity	intensity	NN
cord-006229-7yoilsho	4185	5	was	be	VBD
cord-006229-7yoilsho	4185	6	restricted	restrict	VBN
cord-006229-7yoilsho	4185	7	to	to	IN
cord-006229-7yoilsho	4185	8	the	the	DT
cord-006229-7yoilsho	4185	9	somata	somata	NN
cord-006229-7yoilsho	4185	10	of	of	IN
cord-006229-7yoilsho	4185	11	dorsomedial	dorsomedial	NNP
cord-006229-7yoilsho	4185	12	striatal	striatal	JJ
cord-006229-7yoilsho	4185	13	IN	in	IN
cord-006229-7yoilsho	4185	14	(	(	-LRB-
cord-006229-7yoilsho	4185	15	32	32	CD
cord-006229-7yoilsho	4185	16	%	%	NN
cord-006229-7yoilsho	4185	17	)	)	-RRB-
cord-006229-7yoilsho	4185	18	of	of	IN
cord-006229-7yoilsho	4185	19	dt	dt	NNP
cord-006229-7yoilsho	4185	20	sz	sz	NNP
cord-006229-7yoilsho	4185	21	hamsters	hamster	NNS
cord-006229-7yoilsho	4185	22	,	,	,
cord-006229-7yoilsho	4185	23	indicating	indicate	VBG
cord-006229-7yoilsho	4185	24	both	both	CC
cord-006229-7yoilsho	4185	25	a	a	DT
cord-006229-7yoilsho	4185	26	reduced	reduce	VBN
cord-006229-7yoilsho	4185	27	density	density	NN
cord-006229-7yoilsho	4185	28	as	as	RB
cord-006229-7yoilsho	4185	29	well	well	RB
cord-006229-7yoilsho	4185	30	as	as	IN
cord-006229-7yoilsho	4185	31	a	a	DT
cord-006229-7yoilsho	4185	32	delayed	delay	VBN
cord-006229-7yoilsho	4185	33	maturation	maturation	NN
cord-006229-7yoilsho	4185	34	.	.	.
cord-006229-7yoilsho	4186	1	These	these	DT
cord-006229-7yoilsho	4186	2	findings	finding	NNS
cord-006229-7yoilsho	4186	3	prompted	prompt	VBD
cord-006229-7yoilsho	4186	4	us	-PRON-	PRP
cord-006229-7yoilsho	4186	5	to	to	TO
cord-006229-7yoilsho	4186	6	examine	examine	VB
cord-006229-7yoilsho	4186	7	the	the	DT
cord-006229-7yoilsho	4186	8	effects	effect	NNS
cord-006229-7yoilsho	4186	9	of	of	IN
cord-006229-7yoilsho	4186	10	the	the	DT
cord-006229-7yoilsho	4186	11	αlpha1	αlpha1	NN
cord-006229-7yoilsho	4187	1	GABA	GABA	NNP
cord-006229-7yoilsho	4187	2	A	a	DT
cord-006229-7yoilsho	4187	3	R	r	NN
cord-006229-7yoilsho	4187	4	preferring	prefer	VBG
cord-006229-7yoilsho	4187	5	compound	compound	NN
cord-006229-7yoilsho	4187	6	zolpidem	zolpidem	NN
cord-006229-7yoilsho	4187	7	in	in	IN
cord-006229-7yoilsho	4187	8	comparison	comparison	NN
cord-006229-7yoilsho	4187	9	with	with	IN
cord-006229-7yoilsho	4187	10	the	the	DT
cord-006229-7yoilsho	4187	11	benzodiazepine	benzodiazepine	NN
cord-006229-7yoilsho	4187	12	clonazepam	clonazepam	NN
cord-006229-7yoilsho	4187	13	.	.	.
cord-006229-7yoilsho	4188	1	Zolpidem	Zolpidem	NNP
cord-006229-7yoilsho	4188	2	(	(	-LRB-
cord-006229-7yoilsho	4188	3	2.0	2.0	CD
cord-006229-7yoilsho	4188	4	and	and	CC
cord-006229-7yoilsho	4188	5	10.0	10.0	CD
cord-006229-7yoilsho	4188	6	mg	mg	NNP
cord-006229-7yoilsho	4188	7	/	/	SYM
cord-006229-7yoilsho	4188	8	kg	kg	NNP
cord-006229-7yoilsho	4188	9	i.p	i.p	NNP
cord-006229-7yoilsho	4188	10	.	.	.
cord-006229-7yoilsho	4188	11	)	)	-RRB-
cord-006229-7yoilsho	4189	1	only	only	RB
cord-006229-7yoilsho	4189	2	exerted	exert	VBD
cord-006229-7yoilsho	4189	3	moderate	moderate	JJ
cord-006229-7yoilsho	4189	4	antidystonic	antidystonic	JJ
cord-006229-7yoilsho	4189	5	effects	effect	NNS
cord-006229-7yoilsho	4189	6	compared	compare	VBN
cord-006229-7yoilsho	4189	7	to	to	IN
cord-006229-7yoilsho	4189	8	the	the	DT
cord-006229-7yoilsho	4189	9	benzodiazepine	benzodiazepine	NN
cord-006229-7yoilsho	4189	10	clonazepam	clonazepam	NN
cord-006229-7yoilsho	4189	11	(	(	-LRB-
cord-006229-7yoilsho	4189	12	0.5	0.5	CD
cord-006229-7yoilsho	4189	13	and	and	CC
cord-006229-7yoilsho	4189	14	1.0	1.0	CD
cord-006229-7yoilsho	4189	15	mg	mg	NNP
cord-006229-7yoilsho	4189	16	/	/	SYM
cord-006229-7yoilsho	4189	17	kg	kg	NNP
cord-006229-7yoilsho	4189	18	i.p	i.p	NNP
cord-006229-7yoilsho	4189	19	.	.	NNP
cord-006229-7yoilsho	4189	20	)	)	-RRB-
cord-006229-7yoilsho	4189	21	in	in	IN
cord-006229-7yoilsho	4189	22	the	the	DT
cord-006229-7yoilsho	4189	23	dt	dt	NN
cord-006229-7yoilsho	4189	24	sz	sz	NNP
cord-006229-7yoilsho	4189	25	hamster	hamster	NN
cord-006229-7yoilsho	4189	26	.	.	.
cord-006229-7yoilsho	4190	1	Examinations	examination	NNS
cord-006229-7yoilsho	4190	2	of	of	IN
cord-006229-7yoilsho	4190	3	αlpha2	αlpha2	NN
cord-006229-7yoilsho	4190	4	GABA	GABA	NNP
cord-006229-7yoilsho	4190	5	A	A	NNP
cord-006229-7yoilsho	4190	6	R	r	NN
cord-006229-7yoilsho	4190	7	preferring	preferring	NN
cord-006229-7yoilsho	4190	8	compounds	compound	NNS
cord-006229-7yoilsho	4190	9	are	be	VBP
cord-006229-7yoilsho	4190	10	ongoing	ongoing	JJ
cord-006229-7yoilsho	4190	11	.	.	.
cord-006229-7yoilsho	4191	1	In	in	IN
cord-006229-7yoilsho	4191	2	summary	summary	NN
cord-006229-7yoilsho	4191	3	our	-PRON-	PRP$
cord-006229-7yoilsho	4191	4	studies	study	NNS
cord-006229-7yoilsho	4191	5	indicate	indicate	VBP
cord-006229-7yoilsho	4191	6	that	that	IN
cord-006229-7yoilsho	4191	7	there	there	EX
cord-006229-7yoilsho	4191	8	is	be	VBZ
cord-006229-7yoilsho	4191	9	no	no	DT
cord-006229-7yoilsho	4191	10	general	general	JJ
cord-006229-7yoilsho	4191	11	defect	defect	NN
cord-006229-7yoilsho	4191	12	in	in	IN
cord-006229-7yoilsho	4191	13	striatal	striatal	JJ
cord-006229-7yoilsho	4191	14	GABAergic	gabaergic	NN
cord-006229-7yoilsho	4191	15	maturation	maturation	NN
cord-006229-7yoilsho	4191	16	in	in	IN
cord-006229-7yoilsho	4191	17	the	the	DT
cord-006229-7yoilsho	4191	18	dt	dt	NN
cord-006229-7yoilsho	4191	19	sz	sz	NN
cord-006229-7yoilsho	4191	20	mutant	mutant	NN
cord-006229-7yoilsho	4191	21	but	but	CC
cord-006229-7yoilsho	4191	22	a	a	DT
cord-006229-7yoilsho	4191	23	specific	specific	JJ
cord-006229-7yoilsho	4191	24	alteration	alteration	NN
cord-006229-7yoilsho	4191	25	of	of	IN
cord-006229-7yoilsho	4191	26	striatal	striatal	JJ
cord-006229-7yoilsho	4191	27	GABAergic	GABAergic	NNP
cord-006229-7yoilsho	4191	28	interneurons	interneuron	NNS
cord-006229-7yoilsho	4191	29	which	which	WDT
cord-006229-7yoilsho	4191	30	express	express	VBP
cord-006229-7yoilsho	4191	31	αlpha1	αlpha1	NN
cord-006229-7yoilsho	4191	32	GABA	GABA	NNP
cord-006229-7yoilsho	4191	33	A	A	NNP
cord-006229-7yoilsho	4191	34	R	r	NN
cord-006229-7yoilsho	4191	35	subunits	subunit	NNS
cord-006229-7yoilsho	4191	36	.	.	.
cord-006229-7yoilsho	4192	1	Changes	change	NNS
cord-006229-7yoilsho	4192	2	in	in	IN
cord-006229-7yoilsho	4192	3	αlpha1	αlpha1	NN
cord-006229-7yoilsho	4193	1	GABA	GABA	NNP
cord-006229-7yoilsho	4193	2	A	a	DT
cord-006229-7yoilsho	4193	3	R	r	NN
cord-006229-7yoilsho	4193	4	subunit	subunit	NN
cord-006229-7yoilsho	4193	5	expression	expression	NN
cord-006229-7yoilsho	4193	6	and	and	CC
cord-006229-7yoilsho	4193	7	differences	difference	NNS
cord-006229-7yoilsho	4193	8	in	in	IN
cord-006229-7yoilsho	4193	9	the	the	DT
cord-006229-7yoilsho	4193	10	antidystonic	antidystonic	NNP
cord-006229-7yoilsho	4193	11	efficacy	efficacy	NN
cord-006229-7yoilsho	4193	12	of	of	IN
cord-006229-7yoilsho	4193	13	zolpidem	zolpidem	NNP
cord-006229-7yoilsho	4193	14	and	and	CC
cord-006229-7yoilsho	4193	15	clonazepam	clonazepam	NN
cord-006229-7yoilsho	4193	16	indicate	indicate	VBP
cord-006229-7yoilsho	4193	17	that	that	IN
cord-006229-7yoilsho	4193	18	further	further	JJ
cord-006229-7yoilsho	4193	19	investigations	investigation	NNS
cord-006229-7yoilsho	4193	20	on	on	IN
cord-006229-7yoilsho	4193	21	the	the	DT
cord-006229-7yoilsho	4193	22	role	role	NN
cord-006229-7yoilsho	4193	23	of	of	IN
cord-006229-7yoilsho	4193	24	GABA	GABA	NNP
cord-006229-7yoilsho	4193	25	A	A	NNP
cord-006229-7yoilsho	4193	26	R	r	NN
cord-006229-7yoilsho	4193	27	subunits	subunit	NNS
cord-006229-7yoilsho	4193	28	could	could	MD
cord-006229-7yoilsho	4193	29	lead	lead	VB
cord-006229-7yoilsho	4193	30	to	to	IN
cord-006229-7yoilsho	4193	31	new	new	JJ
cord-006229-7yoilsho	4193	32	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	4193	33	approaches	approach	NNS
cord-006229-7yoilsho	4193	34	for	for	IN
cord-006229-7yoilsho	4193	35	the	the	DT
cord-006229-7yoilsho	4193	36	treatment	treatment	NN
cord-006229-7yoilsho	4193	37	of	of	IN
cord-006229-7yoilsho	4193	38	dystonia	dystonia	NN
cord-006229-7yoilsho	4193	39	.	.	.
cord-006229-7yoilsho	4194	1	2005	2005	CD
cord-006229-7yoilsho	4194	2	)	)	-RRB-
cord-006229-7yoilsho	4194	3	.	.	.
cord-006229-7yoilsho	4195	1	Therefore	therefore	RB
cord-006229-7yoilsho	4195	2	,	,	,
cord-006229-7yoilsho	4195	3	the	the	DT
cord-006229-7yoilsho	4195	4	hypothesis	hypothesis	NN
cord-006229-7yoilsho	4195	5	of	of	IN
cord-006229-7yoilsho	4195	6	the	the	DT
cord-006229-7yoilsho	4195	7	present	present	JJ
cord-006229-7yoilsho	4195	8	study	study	NN
cord-006229-7yoilsho	4195	9	was	be	VBD
cord-006229-7yoilsho	4195	10	that	that	IN
cord-006229-7yoilsho	4195	11	pregnenolone	pregnenolone	NN
cord-006229-7yoilsho	4195	12	attenuates	attenuate	VBZ
cord-006229-7yoilsho	4195	13	the	the	DT
cord-006229-7yoilsho	4195	14	inhibition	inhibition	NN
cord-006229-7yoilsho	4195	15	of	of	IN
cord-006229-7yoilsho	4195	16	synaptic	synaptic	JJ
cord-006229-7yoilsho	4195	17	transmission	transmission	NN
cord-006229-7yoilsho	4195	18	elicited	elicit	VBN
cord-006229-7yoilsho	4195	19	by	by	IN
cord-006229-7yoilsho	4195	20	cannabinoids	cannabinoid	NNS
cord-006229-7yoilsho	4195	21	.	.	.
cord-006229-7yoilsho	4196	1	Methods	method	NNS
cord-006229-7yoilsho	4196	2	:	:	:
cord-006229-7yoilsho	4196	3	250	250	CD
cord-006229-7yoilsho	4196	4	µm	µm	JJ
cord-006229-7yoilsho	4196	5	-	-	HYPH
cord-006229-7yoilsho	4196	6	thick	thick	JJ
cord-006229-7yoilsho	4196	7	slices	slice	NNS
cord-006229-7yoilsho	4196	8	containing	contain	VBG
cord-006229-7yoilsho	4196	9	the	the	DT
cord-006229-7yoilsho	4196	10	cerebellum	cerebellum	NN
cord-006229-7yoilsho	4196	11	and	and	CC
cord-006229-7yoilsho	4196	12	the	the	DT
cord-006229-7yoilsho	4196	13	nucleus	nucleus	NN
cord-006229-7yoilsho	4196	14	accumbens	accumben	NNS
cord-006229-7yoilsho	4196	15	were	be	VBD
cord-006229-7yoilsho	4196	16	prepared	prepare	VBN
cord-006229-7yoilsho	4196	17	from	from	IN
cord-006229-7yoilsho	4196	18	the	the	DT
cord-006229-7yoilsho	4196	19	brains	brain	NNS
cord-006229-7yoilsho	4196	20	of	of	IN
cord-006229-7yoilsho	4196	21	mice	mouse	NNS
cord-006229-7yoilsho	4196	22	and	and	CC
cord-006229-7yoilsho	4196	23	rats	rat	NNS
cord-006229-7yoilsho	4196	24	.	.	.
cord-006229-7yoilsho	4197	1	Spontaneous	spontaneous	JJ
cord-006229-7yoilsho	4197	2	and	and	CC
cord-006229-7yoilsho	4197	3	electrically	electrically	RB
cord-006229-7yoilsho	4197	4	evoked	evoke	VBN
cord-006229-7yoilsho	4197	5	GABAergic	gabaergic	JJ
cord-006229-7yoilsho	4197	6	inhibitory	inhibitory	JJ
cord-006229-7yoilsho	4197	7	postsynaptic	postsynaptic	JJ
cord-006229-7yoilsho	4197	8	currents	current	NNS
cord-006229-7yoilsho	4197	9	(	(	-LRB-
cord-006229-7yoilsho	4197	10	sIPSCs	sipscs	NN
cord-006229-7yoilsho	4197	11	and	and	CC
cord-006229-7yoilsho	4197	12	eIPSCs	eipscs	NN
cord-006229-7yoilsho	4197	13	)	)	-RRB-
cord-006229-7yoilsho	4197	14	and	and	CC
cord-006229-7yoilsho	4197	15	evoked	evoke	VBD
cord-006229-7yoilsho	4197	16	glutamatergic	glutamatergic	JJ
cord-006229-7yoilsho	4197	17	excitatory	excitatory	JJ
cord-006229-7yoilsho	4197	18	postsynaptic	postsynaptic	JJ
cord-006229-7yoilsho	4197	19	currents	current	NNS
cord-006229-7yoilsho	4197	20	(	(	-LRB-
cord-006229-7yoilsho	4197	21	eEPSCs	eepscs	NN
cord-006229-7yoilsho	4197	22	)	)	-RRB-
cord-006229-7yoilsho	4197	23	were	be	VBD
cord-006229-7yoilsho	4197	24	analyzed	analyze	VBN
cord-006229-7yoilsho	4197	25	in	in	IN
cord-006229-7yoilsho	4197	26	superfused	superfused	JJ
cord-006229-7yoilsho	4197	27	brain	brain	NN
cord-006229-7yoilsho	4197	28	slices	slice	NNS
cord-006229-7yoilsho	4197	29	with	with	IN
cord-006229-7yoilsho	4197	30	patch	patch	NN
cord-006229-7yoilsho	4197	31	-	-	HYPH
cord-006229-7yoilsho	4197	32	clamp	clamp	NN
cord-006229-7yoilsho	4197	33	electrophysiological	electrophysiological	JJ
cord-006229-7yoilsho	4197	34	techniques	technique	NNS
cord-006229-7yoilsho	4197	35	.	.	.
cord-006229-7yoilsho	4198	1	Results	result	NNS
cord-006229-7yoilsho	4198	2	:	:	:
cord-006229-7yoilsho	4198	3	A	a	NN
cord-006229-7yoilsho	4198	4	)	)	-RRB-
cord-006229-7yoilsho	4199	1	The	the	DT
cord-006229-7yoilsho	4199	2	synthetic	synthetic	JJ
cord-006229-7yoilsho	4199	3	cannabinoids	cannabinoid	NNS
cord-006229-7yoilsho	4200	1	JWH-018	JWH-018	NNP
cord-006229-7yoilsho	4200	2	(	(	-LRB-
cord-006229-7yoilsho	4200	3	5	5	CD
cord-006229-7yoilsho	4200	4	x	x	SYM
cord-006229-7yoilsho	4200	5	10	10	CD
cord-006229-7yoilsho	4200	6	-6	-6	NNP
cord-006229-7yoilsho	4200	7	M	M	NNP
cord-006229-7yoilsho	4200	8	)	)	-RRB-
cord-006229-7yoilsho	4200	9	and	and	CC
cord-006229-7yoilsho	4200	10	JWH-210	JWH-210	NNP
cord-006229-7yoilsho	4200	11	(	(	-LRB-
cord-006229-7yoilsho	4200	12	5	5	CD
cord-006229-7yoilsho	4200	13	x	x	SYM
cord-006229-7yoilsho	4200	14	10	10	CD
cord-006229-7yoilsho	4200	15	-6	-6	NNP
cord-006229-7yoilsho	4200	16	M	M	NNP
cord-006229-7yoilsho	4200	17	)	)	-RRB-
cord-006229-7yoilsho	4200	18	inhibited	inhibit	VBD
cord-006229-7yoilsho	4200	19	the	the	DT
cord-006229-7yoilsho	4200	20	spontaneous	spontaneous	JJ
cord-006229-7yoilsho	4200	21	GABAergic	gabaergic	NN
cord-006229-7yoilsho	4200	22	synaptic	synaptic	JJ
cord-006229-7yoilsho	4200	23	input	input	NN
cord-006229-7yoilsho	4200	24	(	(	-LRB-
cord-006229-7yoilsho	4200	25	sIPSCs	sipscs	NN
cord-006229-7yoilsho	4200	26	)	)	-RRB-
cord-006229-7yoilsho	4200	27	to	to	IN
cord-006229-7yoilsho	4200	28	Purkinje	Purkinje	NNP
cord-006229-7yoilsho	4200	29	cells	cell	NNS
cord-006229-7yoilsho	4200	30	in	in	IN
cord-006229-7yoilsho	4200	31	mouse	mouse	NN
cord-006229-7yoilsho	4200	32	cerebellar	cerebellar	JJ
cord-006229-7yoilsho	4200	33	slices	slice	NNS
cord-006229-7yoilsho	4200	34	.	.	.
cord-006229-7yoilsho	4201	1	The	the	DT
cord-006229-7yoilsho	4201	2	inhibition	inhibition	NN
cord-006229-7yoilsho	4201	3	by	by	IN
cord-006229-7yoilsho	4201	4	JWH-018	JWH-018	NNP
cord-006229-7yoilsho	4201	5	was	be	VBD
cord-006229-7yoilsho	4201	6	not	not	RB
cord-006229-7yoilsho	4201	7	affected	affect	VBN
cord-006229-7yoilsho	4201	8	by	by	IN
cord-006229-7yoilsho	4201	9	pregnenolone	pregnenolone	NN
cord-006229-7yoilsho	4201	10	(	(	-LRB-
cord-006229-7yoilsho	4201	11	10	10	CD
cord-006229-7yoilsho	4201	12	-7	-7	NNP
cord-006229-7yoilsho	4201	13	M	M	NNP
cord-006229-7yoilsho	4201	14	)	)	-RRB-
cord-006229-7yoilsho	4201	15	,	,	,
cord-006229-7yoilsho	4201	16	the	the	DT
cord-006229-7yoilsho	4201	17	inhibition	inhibition	NN
cord-006229-7yoilsho	4201	18	by	by	IN
cord-006229-7yoilsho	4201	19	JWH-210	JWH-210	NNP
cord-006229-7yoilsho	4201	20	was	be	VBD
cord-006229-7yoilsho	4201	21	only	only	RB
cord-006229-7yoilsho	4201	22	marginally	marginally	RB
cord-006229-7yoilsho	4201	23	attenuated	attenuated	JJ
cord-006229-7yoilsho	4201	24	.	.	.
cord-006229-7yoilsho	4202	1	B	b	NN
cord-006229-7yoilsho	4202	2	)	)	-RRB-
cord-006229-7yoilsho	4203	1	The	the	DT
cord-006229-7yoilsho	4203	2	depolarization	depolarization	NN
cord-006229-7yoilsho	4203	3	of	of	IN
cord-006229-7yoilsho	4203	4	the	the	DT
cord-006229-7yoilsho	4203	5	Purkinje	Purkinje	NNP
cord-006229-7yoilsho	4203	6	cells	cell	NNS
cord-006229-7yoilsho	4203	7	induced	induce	VBD
cord-006229-7yoilsho	4203	8	suppression	suppression	NN
cord-006229-7yoilsho	4203	9	of	of	IN
cord-006229-7yoilsho	4203	10	the	the	DT
cord-006229-7yoilsho	4203	11	GABAergic	gabaergic	NN
cord-006229-7yoilsho	4203	12	input	input	NN
cord-006229-7yoilsho	4203	13	to	to	IN
cord-006229-7yoilsho	4203	14	Purkinje	Purkinje	NNP
cord-006229-7yoilsho	4203	15	cells	cell	NNS
cord-006229-7yoilsho	4203	16	(	(	-LRB-
cord-006229-7yoilsho	4203	17	DSI	DSI	NNP
cord-006229-7yoilsho	4203	18	)	)	-RRB-
cord-006229-7yoilsho	4203	19	;	;	:
cord-006229-7yoilsho	4203	20	Pregnenolone	Pregnenolone	NNP
cord-006229-7yoilsho	4203	21	(	(	-LRB-
cord-006229-7yoilsho	4203	22	10	10	CD
cord-006229-7yoilsho	4203	23	-7	-7	NNP
cord-006229-7yoilsho	4203	24	M	M	NNP
cord-006229-7yoilsho	4203	25	)	)	-RRB-
cord-006229-7yoilsho	4203	26	did	do	VBD
cord-006229-7yoilsho	4203	27	not	not	RB
cord-006229-7yoilsho	4203	28	affect	affect	VB
cord-006229-7yoilsho	4203	29	this	this	DT
cord-006229-7yoilsho	4203	30	endocannabinoid	endocannabinoid	NN
cord-006229-7yoilsho	4203	31	-	-	HYPH
cord-006229-7yoilsho	4203	32	mediated	mediate	VBN
cord-006229-7yoilsho	4203	33	form	form	NN
cord-006229-7yoilsho	4203	34	of	of	IN
cord-006229-7yoilsho	4203	35	synaptic	synaptic	JJ
cord-006229-7yoilsho	4203	36	suppression	suppression	NN
cord-006229-7yoilsho	4203	37	.	.	.
cord-006229-7yoilsho	4204	1	C	C	NNP
cord-006229-7yoilsho	4204	2	)	)	-RRB-
cord-006229-7yoilsho	4205	1	In	in	IN
cord-006229-7yoilsho	4205	2	rat	rat	NN
cord-006229-7yoilsho	4205	3	nucleus	nucleus	NN
cord-006229-7yoilsho	4205	4	accumbens	accumben	VBD
cord-006229-7yoilsho	4205	5	slices	slice	NNS
cord-006229-7yoilsho	4205	6	,	,	,
cord-006229-7yoilsho	4205	7	GABAergic	gabaergic	NN
cord-006229-7yoilsho	4205	8	and	and	CC
cord-006229-7yoilsho	4205	9	glutamatergic	glutamatergic	JJ
cord-006229-7yoilsho	4205	10	synaptic	synaptic	JJ
cord-006229-7yoilsho	4205	11	input	input	NN
cord-006229-7yoilsho	4205	12	to	to	IN
cord-006229-7yoilsho	4205	13	medium	medium	JJ
cord-006229-7yoilsho	4205	14	spiny	spiny	JJ
cord-006229-7yoilsho	4205	15	neurons	neuron	NNS
cord-006229-7yoilsho	4205	16	was	be	VBD
cord-006229-7yoilsho	4205	17	activated	activate	VBN
cord-006229-7yoilsho	4205	18	by	by	IN
cord-006229-7yoilsho	4205	19	electrical	electrical	JJ
cord-006229-7yoilsho	4205	20	stimulation	stimulation	NN
cord-006229-7yoilsho	4205	21	of	of	IN
cord-006229-7yoilsho	4205	22	axons	axon	NNS
cord-006229-7yoilsho	4205	23	.	.	.
cord-006229-7yoilsho	4206	1	∆	∆	NNP
cord-006229-7yoilsho	4206	2	9	9	CD
cord-006229-7yoilsho	4206	3	-Tetrahydrocannabinol	-Tetrahydrocannabinol	.
cord-006229-7yoilsho	4207	1	(	(	-LRB-
cord-006229-7yoilsho	4207	2	2	2	CD
cord-006229-7yoilsho	4207	3	x	x	SYM
cord-006229-7yoilsho	4207	4	10	10	CD
cord-006229-7yoilsho	4207	5	-5	-5	NNP
cord-006229-7yoilsho	4207	6	M	M	NNP
cord-006229-7yoilsho	4207	7	)	)	-RRB-
cord-006229-7yoilsho	4207	8	suppressed	suppress	VBD
cord-006229-7yoilsho	4207	9	the	the	DT
cord-006229-7yoilsho	4207	10	GABAergic	gabaergic	NN
cord-006229-7yoilsho	4207	11	and	and	CC
cord-006229-7yoilsho	4207	12	glutamatergic	glutamatergic	JJ
cord-006229-7yoilsho	4207	13	synaptic	synaptic	JJ
cord-006229-7yoilsho	4207	14	transmission	transmission	NN
cord-006229-7yoilsho	4207	15	in	in	IN
cord-006229-7yoilsho	4207	16	the	the	DT
cord-006229-7yoilsho	4207	17	nucleus	nucleus	NN
cord-006229-7yoilsho	4207	18	accumbens	accumben	VBD
cord-006229-7yoilsho	4207	19	.	.	.
cord-006229-7yoilsho	4208	1	These	these	DT
cord-006229-7yoilsho	4208	2	suppressive	suppressive	JJ
cord-006229-7yoilsho	4208	3	effects	effect	NNS
cord-006229-7yoilsho	4208	4	of	of	IN
cord-006229-7yoilsho	4208	5	∆	∆	NN
cord-006229-7yoilsho	4208	6	9tetrahydrocannabinol	9tetrahydrocannabinol	CD
cord-006229-7yoilsho	4208	7	were	be	VBD
cord-006229-7yoilsho	4208	8	not	not	RB
cord-006229-7yoilsho	4208	9	changed	change	VBN
cord-006229-7yoilsho	4208	10	by	by	IN
cord-006229-7yoilsho	4208	11	pregnenolone	pregnenolone	NN
cord-006229-7yoilsho	4208	12	(	(	-LRB-
cord-006229-7yoilsho	4208	13	10	10	CD
cord-006229-7yoilsho	4208	14	-7	-7	NNP
cord-006229-7yoilsho	4208	15	M	M	NNP
cord-006229-7yoilsho	4208	16	)	)	-RRB-
cord-006229-7yoilsho	4208	17	.	.	.
cord-006229-7yoilsho	4209	1	D	D	NNP
cord-006229-7yoilsho	4209	2	)	)	-RRB-
cord-006229-7yoilsho	4209	3	Finally	finally	RB
cord-006229-7yoilsho	4209	4	,	,	,
cord-006229-7yoilsho	4209	5	we	-PRON-	PRP
cord-006229-7yoilsho	4209	6	tested	test	VBD
cord-006229-7yoilsho	4209	7	whether	whether	IN
cord-006229-7yoilsho	4209	8	we	-PRON-	PRP
cord-006229-7yoilsho	4209	9	can	can	MD
cord-006229-7yoilsho	4209	10	observe	observe	VB
cord-006229-7yoilsho	4209	11	neurosteroid	neurosteroid	RB
cord-006229-7yoilsho	4209	12	-	-	HYPH
cord-006229-7yoilsho	4209	13	mediated	mediate	VBN
cord-006229-7yoilsho	4209	14	effects	effect	NNS
cord-006229-7yoilsho	4209	15	in	in	IN
cord-006229-7yoilsho	4209	16	our	-PRON-	PRP$
cord-006229-7yoilsho	4209	17	brain	brain	NN
cord-006229-7yoilsho	4209	18	slice	slice	NN
cord-006229-7yoilsho	4209	19	preparations	preparation	NNS
cord-006229-7yoilsho	4209	20	.	.	.
cord-006229-7yoilsho	4210	1	Tetrahydro	Tetrahydro	NNP
cord-006229-7yoilsho	4210	2	-	-	HYPH
cord-006229-7yoilsho	4210	3	deoxycorticosterone	deoxycorticosterone	NNP
cord-006229-7yoilsho	4210	4	(	(	-LRB-
cord-006229-7yoilsho	4210	5	THDOC	THDOC	NNP
cord-006229-7yoilsho	4210	6	,	,	,
cord-006229-7yoilsho	4210	7	10	10	CD
cord-006229-7yoilsho	4210	8	-6	-6	NNP
cord-006229-7yoilsho	4210	9	M	M	NNP
cord-006229-7yoilsho	4210	10	)	)	-RRB-
cord-006229-7yoilsho	4210	11	markedly	markedly	RB
cord-006229-7yoilsho	4210	12	prolonged	prolong	VBD
cord-006229-7yoilsho	4210	13	the	the	DT
cord-006229-7yoilsho	4210	14	decay	decay	NN
cord-006229-7yoilsho	4210	15	time	time	NN
cord-006229-7yoilsho	4210	16	constant	constant	JJ
cord-006229-7yoilsho	4210	17	(	(	-LRB-
cord-006229-7yoilsho	4210	18	τ	τ	NN
cord-006229-7yoilsho	4210	19	)	)	-RRB-
cord-006229-7yoilsho	4210	20	of	of	IN
cord-006229-7yoilsho	4210	21	spontaneous	spontaneous	JJ
cord-006229-7yoilsho	4210	22	GABAergic	gabaergic	NN
cord-006229-7yoilsho	4210	23	postsynaptic	postsynaptic	JJ
cord-006229-7yoilsho	4210	24	currents	current	NNS
cord-006229-7yoilsho	4210	25	(	(	-LRB-
cord-006229-7yoilsho	4210	26	sIPSCs	sipscs	NN
cord-006229-7yoilsho	4210	27	)	)	-RRB-
cord-006229-7yoilsho	4210	28	,	,	,
cord-006229-7yoilsho	4210	29	similarly	similarly	RB
cord-006229-7yoilsho	4210	30	as	as	IN
cord-006229-7yoilsho	4210	31	in	in	IN
cord-006229-7yoilsho	4210	32	previous	previous	JJ
cord-006229-7yoilsho	4210	33	experiments	experiment	NNS
cord-006229-7yoilsho	4210	34	(	(	-LRB-
cord-006229-7yoilsho	4210	35	EJ	EJ	NNP
cord-006229-7yoilsho	4210	36	Cooper	Cooper	NNP
cord-006229-7yoilsho	4210	37	et	et	NNP
cord-006229-7yoilsho	4210	38	al	al	NNP
cord-006229-7yoilsho	4210	39	.	.	NNP
cord-006229-7yoilsho	4210	40	,	,	,
cord-006229-7yoilsho	4210	41	J	J	NNP
cord-006229-7yoilsho	4210	42	Physiol	Physiol	NNP
cord-006229-7yoilsho	4210	43	521	521	CD
cord-006229-7yoilsho	4210	44	:	:	:
cord-006229-7yoilsho	4210	45	437	437	CD
cord-006229-7yoilsho	4210	46	-	-	SYM
cord-006229-7yoilsho	4210	47	449	449	CD
cord-006229-7yoilsho	4210	48	,	,	,
cord-006229-7yoilsho	4210	49	1999	1999	CD
cord-006229-7yoilsho	4210	50	)	)	-RRB-
cord-006229-7yoilsho	4210	51	.	.	.
cord-006229-7yoilsho	4211	1	The	the	DT
cord-006229-7yoilsho	4211	2	results	result	NNS
cord-006229-7yoilsho	4211	3	show	show	VBP
cord-006229-7yoilsho	4211	4	that	that	IN
cord-006229-7yoilsho	4211	5	inhibition	inhibition	NN
cord-006229-7yoilsho	4211	6	of	of	IN
cord-006229-7yoilsho	4211	7	GABAergic	GABAergic	NNP
cord-006229-7yoilsho	4211	8	and	and	CC
cord-006229-7yoilsho	4211	9	glutamatergic	glutamatergic	JJ
cord-006229-7yoilsho	4211	10	synaptic	synaptic	JJ
cord-006229-7yoilsho	4211	11	transmission	transmission	NN
cord-006229-7yoilsho	4211	12	by	by	IN
cord-006229-7yoilsho	4211	13	synthetic-	synthetic-	NN
cord-006229-7yoilsho	4211	14	,	,	,
cord-006229-7yoilsho	4211	15	endogenous,-and	endogenous,-and	CC
cord-006229-7yoilsho	4211	16	phyto	phyto	NN
cord-006229-7yoilsho	4211	17	-	-	HYPH
cord-006229-7yoilsho	4211	18	cannabinoids	cannabinoid	NNS
cord-006229-7yoilsho	4211	19	is	be	VBZ
cord-006229-7yoilsho	4211	20	not	not	RB
cord-006229-7yoilsho	4211	21	changed	change	VBN
cord-006229-7yoilsho	4211	22	by	by	IN
cord-006229-7yoilsho	4211	23	pregnenolone	pregnenolone	NN
cord-006229-7yoilsho	4211	24	.	.	.
cord-006229-7yoilsho	4212	1	Therefore	therefore	RB
cord-006229-7yoilsho	4212	2	,	,	,
cord-006229-7yoilsho	4212	3	it	-PRON-	PRP
cord-006229-7yoilsho	4212	4	is	be	VBZ
cord-006229-7yoilsho	4212	5	unlikely	unlikely	JJ
cord-006229-7yoilsho	4212	6	that	that	IN
cord-006229-7yoilsho	4212	7	interference	interference	NN
cord-006229-7yoilsho	4212	8	with	with	IN
cord-006229-7yoilsho	4212	9	cannabinoid	cannabinoid	NN
cord-006229-7yoilsho	4212	10	-	-	HYPH
cord-006229-7yoilsho	4212	11	induced	induce	VBN
cord-006229-7yoilsho	4212	12	inhibition	inhibition	NN
cord-006229-7yoilsho	4212	13	of	of	IN
cord-006229-7yoilsho	4212	14	synaptic	synaptic	JJ
cord-006229-7yoilsho	4212	15	transmission	transmission	NN
cord-006229-7yoilsho	4212	16	is	be	VBZ
cord-006229-7yoilsho	4212	17	the	the	DT
cord-006229-7yoilsho	4212	18	mechanism	mechanism	NN
cord-006229-7yoilsho	4212	19	by	by	IN
cord-006229-7yoilsho	4212	20	which	which	WDT
cord-006229-7yoilsho	4212	21	pregnenolone	pregnenolone	NN
cord-006229-7yoilsho	4212	22	attenuates	attenuate	VBZ
cord-006229-7yoilsho	4212	23	behavioural	behavioural	JJ
cord-006229-7yoilsho	4212	24	and	and	CC
cord-006229-7yoilsho	4212	25	somatic	somatic	JJ
cord-006229-7yoilsho	4212	26	effects	effect	NNS
cord-006229-7yoilsho	4212	27	of	of	IN
cord-006229-7yoilsho	4212	28	∆	∆	NNP
cord-006229-7yoilsho	4212	29	9	9	CD
cord-006229-7yoilsho	4212	30	-tetrahydrocannabinol	-tetrahydrocannabinol	CD
cord-006229-7yoilsho	4212	31	in	in	IN
cord-006229-7yoilsho	4212	32	vivo	vivo	NN
cord-006229-7yoilsho	4212	33	.	.	.
cord-006229-7yoilsho	4213	1	The	the	DT
cord-006229-7yoilsho	4213	2	hypothalamus	hypothalamus	NN
cord-006229-7yoilsho	4213	3	is	be	VBZ
cord-006229-7yoilsho	4213	4	one	one	CD
cord-006229-7yoilsho	4213	5	of	of	IN
cord-006229-7yoilsho	4213	6	the	the	DT
cord-006229-7yoilsho	4213	7	key	key	JJ
cord-006229-7yoilsho	4213	8	players	player	NNS
cord-006229-7yoilsho	4213	9	in	in	IN
cord-006229-7yoilsho	4213	10	the	the	DT
cord-006229-7yoilsho	4213	11	regulation	regulation	NN
cord-006229-7yoilsho	4213	12	of	of	IN
cord-006229-7yoilsho	4213	13	the	the	DT
cord-006229-7yoilsho	4213	14	energy	energy	NN
cord-006229-7yoilsho	4213	15	homeostasis	homeostasis	NN
cord-006229-7yoilsho	4213	16	.	.	.
cord-006229-7yoilsho	4214	1	Cold	cold	JJ
cord-006229-7yoilsho	4214	2	stress	stress	NN
cord-006229-7yoilsho	4214	3	leads	lead	VBZ
cord-006229-7yoilsho	4214	4	to	to	IN
cord-006229-7yoilsho	4214	5	an	an	DT
cord-006229-7yoilsho	4214	6	activation	activation	NN
cord-006229-7yoilsho	4214	7	of	of	IN
cord-006229-7yoilsho	4214	8	neurons	neuron	NNS
cord-006229-7yoilsho	4214	9	in	in	IN
cord-006229-7yoilsho	4214	10	the	the	DT
cord-006229-7yoilsho	4214	11	paraventricular	paraventricular	NNP
cord-006229-7yoilsho	4214	12	hypothalamic	hypothalamic	JJ
cord-006229-7yoilsho	4214	13	nucleus	nucleus	NN
cord-006229-7yoilsho	4214	14	(	(	-LRB-
cord-006229-7yoilsho	4214	15	PVN	PVN	NNP
cord-006229-7yoilsho	4214	16	)	)	-RRB-
cord-006229-7yoilsho	4214	17	and	and	CC
cord-006229-7yoilsho	4214	18	increases	increase	VBZ
cord-006229-7yoilsho	4214	19	thermogenesis	thermogenesis	NN
cord-006229-7yoilsho	4214	20	.	.	.
cord-006229-7yoilsho	4215	1	The	the	DT
cord-006229-7yoilsho	4215	2	Thyrotropin	Thyrotropin	NNP
cord-006229-7yoilsho	4215	3	-	-	HYPH
cord-006229-7yoilsho	4215	4	Releasing	release	VBG
cord-006229-7yoilsho	4215	5	-	-	HYPH
cord-006229-7yoilsho	4215	6	Hormone	hormone	NN
cord-006229-7yoilsho	4215	7	(	(	-LRB-
cord-006229-7yoilsho	4215	8	TRH	TRH	NNP
cord-006229-7yoilsho	4215	9	)	)	-RRB-
cord-006229-7yoilsho	4215	10	neurons	neuron	NNS
cord-006229-7yoilsho	4215	11	have	have	VBP
cord-006229-7yoilsho	4215	12	an	an	DT
cord-006229-7yoilsho	4215	13	important	important	JJ
cord-006229-7yoilsho	4215	14	function	function	NN
cord-006229-7yoilsho	4215	15	in	in	IN
cord-006229-7yoilsho	4215	16	this	this	DT
cord-006229-7yoilsho	4215	17	effect	effect	NN
cord-006229-7yoilsho	4215	18	.	.	.
cord-006229-7yoilsho	4216	1	However	however	RB
cord-006229-7yoilsho	4216	2	it	-PRON-	PRP
cord-006229-7yoilsho	4216	3	is	be	VBZ
cord-006229-7yoilsho	4216	4	hardly	hardly	RB
cord-006229-7yoilsho	4216	5	understood	understand	VBN
cord-006229-7yoilsho	4216	6	which	which	WDT
cord-006229-7yoilsho	4216	7	role	role	NN
cord-006229-7yoilsho	4216	8	the	the	DT
cord-006229-7yoilsho	4216	9	TRH	TRH	NNP
cord-006229-7yoilsho	4216	10	neurons	neuron	NNS
cord-006229-7yoilsho	4216	11	exactly	exactly	RB
cord-006229-7yoilsho	4216	12	play	play	VBP
cord-006229-7yoilsho	4216	13	and	and	CC
cord-006229-7yoilsho	4216	14	how	how	WRB
cord-006229-7yoilsho	4216	15	they	-PRON-	PRP
cord-006229-7yoilsho	4216	16	are	be	VBP
cord-006229-7yoilsho	4216	17	connected	connect	VBN
cord-006229-7yoilsho	4216	18	to	to	IN
cord-006229-7yoilsho	4216	19	other	other	JJ
cord-006229-7yoilsho	4216	20	regions	region	NNS
cord-006229-7yoilsho	4216	21	of	of	IN
cord-006229-7yoilsho	4216	22	the	the	DT
cord-006229-7yoilsho	4216	23	brain	brain	NN
cord-006229-7yoilsho	4216	24	.	.	.
cord-006229-7yoilsho	4217	1	We	-PRON-	PRP
cord-006229-7yoilsho	4217	2	have	have	VBP
cord-006229-7yoilsho	4217	3	transduced	transduce	VBN
cord-006229-7yoilsho	4217	4	neurons	neuron	NNS
cord-006229-7yoilsho	4217	5	in	in	IN
cord-006229-7yoilsho	4217	6	the	the	DT
cord-006229-7yoilsho	4217	7	PVN	PVN	NNP
cord-006229-7yoilsho	4217	8	of	of	IN
cord-006229-7yoilsho	4217	9	mice	mouse	NNS
cord-006229-7yoilsho	4217	10	with	with	IN
cord-006229-7yoilsho	4217	11	a	a	DT
cord-006229-7yoilsho	4217	12	recombinant	recombinant	JJ
cord-006229-7yoilsho	4217	13	adeno	adeno	NN
cord-006229-7yoilsho	4217	14	associated	associate	VBN
cord-006229-7yoilsho	4217	15	virus	virus	NN
cord-006229-7yoilsho	4217	16	which	which	WDT
cord-006229-7yoilsho	4217	17	contains	contain	VBZ
cord-006229-7yoilsho	4217	18	an	an	DT
cord-006229-7yoilsho	4217	19	activating	activate	VBG
cord-006229-7yoilsho	4217	20	"	"	``
cord-006229-7yoilsho	4217	21	Designer	designer	NN
cord-006229-7yoilsho	4217	22	Receptors	receptor	NNS
cord-006229-7yoilsho	4217	23	Exclusively	exclusively	RB
cord-006229-7yoilsho	4217	24	Activated	activate	VBN
cord-006229-7yoilsho	4217	25	by	by	IN
cord-006229-7yoilsho	4217	26	Designer	designer	NN
cord-006229-7yoilsho	4217	27	Drugs	drug	NNS
cord-006229-7yoilsho	4217	28	"	"	''
cord-006229-7yoilsho	4217	29	(	(	-LRB-
cord-006229-7yoilsho	4217	30	DREADD	DREADD	NNP
cord-006229-7yoilsho	4217	31	)	)	-RRB-
cord-006229-7yoilsho	4217	32	system	system	NN
cord-006229-7yoilsho	4217	33	under	under	IN
cord-006229-7yoilsho	4217	34	the	the	DT
cord-006229-7yoilsho	4217	35	control	control	NN
cord-006229-7yoilsho	4217	36	of	of	IN
cord-006229-7yoilsho	4217	37	a	a	DT
cord-006229-7yoilsho	4217	38	shortened	shorten	VBN
cord-006229-7yoilsho	4217	39	TRH	TRH	NNP
cord-006229-7yoilsho	4217	40	promotor	promotor	NN
cord-006229-7yoilsho	4217	41	.	.	.
cord-006229-7yoilsho	4218	1	Two	two	CD
cord-006229-7yoilsho	4218	2	weeks	week	NNS
cord-006229-7yoilsho	4218	3	after	after	IN
cord-006229-7yoilsho	4218	4	transduction	transduction	NN
cord-006229-7yoilsho	4218	5	the	the	DT
cord-006229-7yoilsho	4218	6	animals	animal	NNS
cord-006229-7yoilsho	4218	7	were	be	VBD
cord-006229-7yoilsho	4218	8	injected	inject	VBN
cord-006229-7yoilsho	4218	9	with	with	IN
cord-006229-7yoilsho	4218	10	clozapine	clozapine	NNP
cord-006229-7yoilsho	4218	11	-	-	HYPH
cord-006229-7yoilsho	4218	12	N	n	NN
cord-006229-7yoilsho	4218	13	-	-	HYPH
cord-006229-7yoilsho	4218	14	oxide	oxide	NN
cord-006229-7yoilsho	4218	15	(	(	-LRB-
cord-006229-7yoilsho	4218	16	CNO	CNO	NNP
cord-006229-7yoilsho	4218	17	)	)	-RRB-
cord-006229-7yoilsho	4218	18	.	.	.
cord-006229-7yoilsho	4219	1	To	to	TO
cord-006229-7yoilsho	4219	2	analyse	analyse	VB
cord-006229-7yoilsho	4219	3	the	the	DT
cord-006229-7yoilsho	4219	4	physiological	physiological	JJ
cord-006229-7yoilsho	4219	5	function	function	NN
cord-006229-7yoilsho	4219	6	of	of	IN
cord-006229-7yoilsho	4219	7	this	this	DT
cord-006229-7yoilsho	4219	8	neurons	neuron	NNS
cord-006229-7yoilsho	4219	9	we	-PRON-	PRP
cord-006229-7yoilsho	4219	10	performed	perform	VBD
cord-006229-7yoilsho	4219	11	indirect	indirect	JJ
cord-006229-7yoilsho	4219	12	calorimetry	calorimetry	NN
cord-006229-7yoilsho	4219	13	,	,	,
cord-006229-7yoilsho	4219	14	measured	measure	VBN
cord-006229-7yoilsho	4219	15	rectal	rectal	JJ
cord-006229-7yoilsho	4219	16	temperature	temperature	NN
cord-006229-7yoilsho	4219	17	and	and	CC
cord-006229-7yoilsho	4219	18	thermogenesis	thermogenesis	NN
cord-006229-7yoilsho	4219	19	in	in	IN
cord-006229-7yoilsho	4219	20	the	the	DT
cord-006229-7yoilsho	4219	21	brown	brown	JJ
cord-006229-7yoilsho	4219	22	adipose	adipose	JJ
cord-006229-7yoilsho	4219	23	tissue	tissue	NN
cord-006229-7yoilsho	4219	24	(	(	-LRB-
cord-006229-7yoilsho	4219	25	BAT	bat	NN
cord-006229-7yoilsho	4219	26	)	)	-RRB-
cord-006229-7yoilsho	4219	27	,	,	,
cord-006229-7yoilsho	4219	28	analysed	analyse	VBD
cord-006229-7yoilsho	4219	29	drinking	drink	VBG
cord-006229-7yoilsho	4219	30	feeding	feed	VBG
cord-006229-7yoilsho	4219	31	behaviour	behaviour	NN
cord-006229-7yoilsho	4219	32	and	and	CC
cord-006229-7yoilsho	4219	33	the	the	DT
cord-006229-7yoilsho	4219	34	home	home	NN
cord-006229-7yoilsho	4219	35	cage	cage	NN
cord-006229-7yoilsho	4219	36	activity	activity	NN
cord-006229-7yoilsho	4219	37	.	.	.
cord-006229-7yoilsho	4220	1	After	after	IN
cord-006229-7yoilsho	4220	2	stimulation	stimulation	NN
cord-006229-7yoilsho	4220	3	we	-PRON-	PRP
cord-006229-7yoilsho	4220	4	measured	measure	VBD
cord-006229-7yoilsho	4220	5	the	the	DT
cord-006229-7yoilsho	4220	6	expression	expression	NN
cord-006229-7yoilsho	4220	7	of	of	IN
cord-006229-7yoilsho	4220	8	genes	gene	NNS
cord-006229-7yoilsho	4220	9	in	in	IN
cord-006229-7yoilsho	4220	10	BAT	bat	NN
cord-006229-7yoilsho	4220	11	as	as	RB
cord-006229-7yoilsho	4220	12	well	well	RB
cord-006229-7yoilsho	4220	13	plasma	plasma	NN
cord-006229-7yoilsho	4220	14	hormone	hormone	NN
cord-006229-7yoilsho	4220	15	levels	level	NNS
cord-006229-7yoilsho	4220	16	of	of	IN
cord-006229-7yoilsho	4220	17	pituitary	pituitary	JJ
cord-006229-7yoilsho	4220	18	hormones	hormone	NNS
cord-006229-7yoilsho	4220	19	.	.	.
cord-006229-7yoilsho	4221	1	Propranolol	propranolol	NN
cord-006229-7yoilsho	4221	2	and	and	CC
cord-006229-7yoilsho	4221	3	the	the	DT
cord-006229-7yoilsho	4221	4	specific	specific	JJ
cord-006229-7yoilsho	4221	5	β3-antagonist	β3-antagonist	NN
cord-006229-7yoilsho	4221	6	SR59230A	SR59230A	NNS
cord-006229-7yoilsho	4221	7	were	be	VBD
cord-006229-7yoilsho	4221	8	used	use	VBN
cord-006229-7yoilsho	4221	9	to	to	TO
cord-006229-7yoilsho	4221	10	analyse	analyse	VB
cord-006229-7yoilsho	4221	11	the	the	DT
cord-006229-7yoilsho	4221	12	relevance	relevance	NN
cord-006229-7yoilsho	4221	13	of	of	IN
cord-006229-7yoilsho	4221	14	the	the	DT
cord-006229-7yoilsho	4221	15	sympathetic	sympathetic	JJ
cord-006229-7yoilsho	4221	16	system	system	NN
cord-006229-7yoilsho	4221	17	.	.	.
cord-006229-7yoilsho	4222	1	To	to	TO
cord-006229-7yoilsho	4222	2	further	further	RB
cord-006229-7yoilsho	4222	3	characterise	characterise	VB
cord-006229-7yoilsho	4222	4	the	the	DT
cord-006229-7yoilsho	4222	5	transduced	transduce	VBN
cord-006229-7yoilsho	4222	6	neurons	neuron	NNS
cord-006229-7yoilsho	4222	7	and	and	CC
cord-006229-7yoilsho	4222	8	their	-PRON-	PRP$
cord-006229-7yoilsho	4222	9	projections	projection	NNS
cord-006229-7yoilsho	4222	10	we	-PRON-	PRP
cord-006229-7yoilsho	4222	11	used	use	VBD
cord-006229-7yoilsho	4222	12	immunohistochemistry	immunohistochemistry	NN
cord-006229-7yoilsho	4222	13	methods	method	NNS
cord-006229-7yoilsho	4222	14	.	.	.
cord-006229-7yoilsho	4223	1	After	after	IN
cord-006229-7yoilsho	4223	2	stimulation	stimulation	NN
cord-006229-7yoilsho	4223	3	with	with	IN
cord-006229-7yoilsho	4223	4	CNO	CNO	NNP
cord-006229-7yoilsho	4223	5	the	the	DT
cord-006229-7yoilsho	4223	6	energy	energy	NN
cord-006229-7yoilsho	4223	7	expenditure	expenditure	NN
cord-006229-7yoilsho	4223	8	and	and	CC
cord-006229-7yoilsho	4223	9	body	body	NN
cord-006229-7yoilsho	4223	10	temperature	temperature	NN
cord-006229-7yoilsho	4223	11	were	be	VBD
cord-006229-7yoilsho	4223	12	increased	increase	VBN
cord-006229-7yoilsho	4223	13	.	.	.
cord-006229-7yoilsho	4224	1	These	these	DT
cord-006229-7yoilsho	4224	2	effects	effect	NNS
cord-006229-7yoilsho	4224	3	were	be	VBD
cord-006229-7yoilsho	4224	4	mostly	mostly	RB
cord-006229-7yoilsho	4224	5	driven	drive	VBN
cord-006229-7yoilsho	4224	6	through	through	IN
cord-006229-7yoilsho	4224	7	an	an	DT
cord-006229-7yoilsho	4224	8	activation	activation	NN
cord-006229-7yoilsho	4224	9	of	of	IN
cord-006229-7yoilsho	4224	10	the	the	DT
cord-006229-7yoilsho	4224	11	brown	brown	JJ
cord-006229-7yoilsho	4224	12	adipose	adipose	JJ
cord-006229-7yoilsho	4224	13	tissue	tissue	NN
cord-006229-7yoilsho	4224	14	(	(	-LRB-
cord-006229-7yoilsho	4224	15	BAT	bat	NN
cord-006229-7yoilsho	4224	16	)	)	-RRB-
cord-006229-7yoilsho	4224	17	.	.	.
cord-006229-7yoilsho	4225	1	In	in	IN
cord-006229-7yoilsho	4225	2	DREADD	DREADD	NNP
cord-006229-7yoilsho	4225	3	transduced	transduce	VBN
cord-006229-7yoilsho	4225	4	TRH	TRH	NNP
cord-006229-7yoilsho	4225	5	-	-	HYPH
cord-006229-7yoilsho	4225	6	receptor	receptor	NN
cord-006229-7yoilsho	4225	7	1	1	CD
cord-006229-7yoilsho	4226	1	(	(	-LRB-
cord-006229-7yoilsho	4226	2	TRH	TRH	NNP
cord-006229-7yoilsho	4226	3	-	-	HYPH
cord-006229-7yoilsho	4226	4	R1	R1	NNP
cord-006229-7yoilsho	4226	5	)	)	-RRB-
cord-006229-7yoilsho	4226	6	knockout	knockout	NN
cord-006229-7yoilsho	4226	7	mice	mouse	NNS
cord-006229-7yoilsho	4226	8	this	this	DT
cord-006229-7yoilsho	4226	9	effects	effect	NNS
cord-006229-7yoilsho	4226	10	were	be	VBD
cord-006229-7yoilsho	4226	11	abolished	abolish	VBN
cord-006229-7yoilsho	4226	12	.	.	.
cord-006229-7yoilsho	4227	1	In	in	IN
cord-006229-7yoilsho	4227	2	parallel	parallel	JJ
cord-006229-7yoilsho	4227	3	the	the	DT
cord-006229-7yoilsho	4227	4	plasma	plasma	NN
cord-006229-7yoilsho	4227	5	levels	level	NNS
cord-006229-7yoilsho	4227	6	of	of	IN
cord-006229-7yoilsho	4227	7	TSH	TSH	NNP
cord-006229-7yoilsho	4227	8	,	,	,
cord-006229-7yoilsho	4227	9	the	the	DT
cord-006229-7yoilsho	4227	10	UCP1	UCP1	NNP
cord-006229-7yoilsho	4227	11	mRNA	mrna	NN
cord-006229-7yoilsho	4227	12	level	level	NN
cord-006229-7yoilsho	4227	13	in	in	IN
cord-006229-7yoilsho	4227	14	the	the	DT
cord-006229-7yoilsho	4227	15	BAT	bat	NN
cord-006229-7yoilsho	4227	16	,	,	,
cord-006229-7yoilsho	4227	17	the	the	DT
cord-006229-7yoilsho	4227	18	home	home	NN
cord-006229-7yoilsho	4227	19	cage	cage	NN
cord-006229-7yoilsho	4227	20	activity	activity	NN
cord-006229-7yoilsho	4227	21	as	as	RB
cord-006229-7yoilsho	4227	22	well	well	RB
cord-006229-7yoilsho	4227	23	the	the	DT
cord-006229-7yoilsho	4227	24	food	food	NN
cord-006229-7yoilsho	4227	25	and	and	CC
cord-006229-7yoilsho	4227	26	water	water	NN
cord-006229-7yoilsho	4227	27	intake	intake	NN
cord-006229-7yoilsho	4227	28	were	be	VBD
cord-006229-7yoilsho	4227	29	increased	increase	VBN
cord-006229-7yoilsho	4227	30	.	.	.
cord-006229-7yoilsho	4228	1	After	after	IN
cord-006229-7yoilsho	4228	2	the	the	DT
cord-006229-7yoilsho	4228	3	treatment	treatment	NN
cord-006229-7yoilsho	4228	4	with	with	IN
cord-006229-7yoilsho	4228	5	propranolol	propranolol	NN
cord-006229-7yoilsho	4228	6	and	and	CC
cord-006229-7yoilsho	4228	7	SR59230A	SR59230A	NNS
cord-006229-7yoilsho	4228	8	the	the	DT
cord-006229-7yoilsho	4228	9	effects	effect	NNS
cord-006229-7yoilsho	4228	10	on	on	IN
cord-006229-7yoilsho	4228	11	the	the	DT
cord-006229-7yoilsho	4228	12	thermogenesis	thermogenesis	NN
cord-006229-7yoilsho	4228	13	were	be	VBD
cord-006229-7yoilsho	4228	14	reduced	reduce	VBN
cord-006229-7yoilsho	4228	15	,	,	,
cord-006229-7yoilsho	4228	16	but	but	CC
cord-006229-7yoilsho	4228	17	the	the	DT
cord-006229-7yoilsho	4228	18	home	home	NN
cord-006229-7yoilsho	4228	19	cage	cage	NN
cord-006229-7yoilsho	4228	20	activity	activity	NN
cord-006229-7yoilsho	4228	21	was	be	VBD
cord-006229-7yoilsho	4228	22	not	not	RB
cord-006229-7yoilsho	4228	23	affected	affect	VBN
cord-006229-7yoilsho	4228	24	.	.	.
cord-006229-7yoilsho	4229	1	SR59230A	SR59230A	NNS
cord-006229-7yoilsho	4229	2	treatment	treatment	NN
cord-006229-7yoilsho	4229	3	normalised	normalise	VBD
cord-006229-7yoilsho	4229	4	the	the	DT
cord-006229-7yoilsho	4229	5	food	food	NN
cord-006229-7yoilsho	4229	6	intake	intake	NN
cord-006229-7yoilsho	4229	7	and	and	CC
cord-006229-7yoilsho	4229	8	increased	increase	VBD
cord-006229-7yoilsho	4229	9	in	in	IN
cord-006229-7yoilsho	4229	10	parallel	parallel	NN
cord-006229-7yoilsho	4229	11	the	the	DT
cord-006229-7yoilsho	4229	12	plasma	plasma	NN
cord-006229-7yoilsho	4229	13	leptin	leptin	NN
cord-006229-7yoilsho	4229	14	concentrations	concentration	NNS
cord-006229-7yoilsho	4229	15	after	after	IN
cord-006229-7yoilsho	4229	16	CNO	CNO	NNP
cord-006229-7yoilsho	4229	17	stimulation	stimulation	NN
cord-006229-7yoilsho	4229	18	.	.	.
cord-006229-7yoilsho	4230	1	Transduced	transduced	JJ
cord-006229-7yoilsho	4230	2	neurons	neuron	NNS
cord-006229-7yoilsho	4230	3	project	project	VBP
cord-006229-7yoilsho	4230	4	into	into	IN
cord-006229-7yoilsho	4230	5	the	the	DT
cord-006229-7yoilsho	4230	6	raphe	raphe	NNP
cord-006229-7yoilsho	4230	7	nucleus	nucleus	NN
cord-006229-7yoilsho	4230	8	,	,	,
cord-006229-7yoilsho	4230	9	the	the	DT
cord-006229-7yoilsho	4230	10	medial	medial	JJ
cord-006229-7yoilsho	4230	11	part	part	NN
cord-006229-7yoilsho	4230	12	of	of	IN
cord-006229-7yoilsho	4230	13	the	the	DT
cord-006229-7yoilsho	4230	14	thalamus	thalamus	NN
cord-006229-7yoilsho	4230	15	and	and	CC
cord-006229-7yoilsho	4230	16	the	the	DT
cord-006229-7yoilsho	4230	17	spinal	spinal	JJ
cord-006229-7yoilsho	4230	18	cord	cord	NN
cord-006229-7yoilsho	4230	19	.	.	.
cord-006229-7yoilsho	4231	1	With	with	IN
cord-006229-7yoilsho	4231	2	our	-PRON-	PRP$
cord-006229-7yoilsho	4231	3	experiments	experiment	NNS
cord-006229-7yoilsho	4231	4	we	-PRON-	PRP
cord-006229-7yoilsho	4231	5	could	could	MD
cord-006229-7yoilsho	4231	6	provide	provide	VB
cord-006229-7yoilsho	4231	7	strong	strong	JJ
cord-006229-7yoilsho	4231	8	evidence	evidence	NN
cord-006229-7yoilsho	4231	9	for	for	IN
cord-006229-7yoilsho	4231	10	a	a	DT
cord-006229-7yoilsho	4231	11	sympathetic	sympathetic	JJ
cord-006229-7yoilsho	4231	12	connection	connection	NN
cord-006229-7yoilsho	4231	13	of	of	IN
cord-006229-7yoilsho	4231	14	the	the	DT
cord-006229-7yoilsho	4231	15	transduced	transduce	VBN
cord-006229-7yoilsho	4231	16	neurons	neuron	NNS
cord-006229-7yoilsho	4231	17	in	in	IN
cord-006229-7yoilsho	4231	18	the	the	DT
cord-006229-7yoilsho	4231	19	PVN	PVN	NNP
cord-006229-7yoilsho	4231	20	to	to	IN
cord-006229-7yoilsho	4231	21	the	the	DT
cord-006229-7yoilsho	4231	22	BAT	bat	NN
cord-006229-7yoilsho	4231	23	and	and	CC
cord-006229-7yoilsho	4231	24	for	for	IN
cord-006229-7yoilsho	4231	25	the	the	DT
cord-006229-7yoilsho	4231	26	involvement	involvement	NN
cord-006229-7yoilsho	4231	27	of	of	IN
cord-006229-7yoilsho	4231	28	THR	THR	NNP
cord-006229-7yoilsho	4231	29	neurons	neuron	NNS
cord-006229-7yoilsho	4231	30	in	in	IN
cord-006229-7yoilsho	4231	31	these	these	DT
cord-006229-7yoilsho	4231	32	effects	effect	NNS
cord-006229-7yoilsho	4231	33	.	.	.
cord-006229-7yoilsho	4232	1	Therefore	therefore	RB
cord-006229-7yoilsho	4232	2	,	,	,
cord-006229-7yoilsho	4232	3	this	this	DT
cord-006229-7yoilsho	4232	4	system	system	NN
cord-006229-7yoilsho	4232	5	is	be	VBZ
cord-006229-7yoilsho	4232	6	a	a	DT
cord-006229-7yoilsho	4232	7	suitable	suitable	JJ
cord-006229-7yoilsho	4232	8	tool	tool	NN
cord-006229-7yoilsho	4232	9	to	to	TO
cord-006229-7yoilsho	4232	10	investigate	investigate	VB
cord-006229-7yoilsho	4232	11	the	the	DT
cord-006229-7yoilsho	4232	12	metabolic	metabolic	JJ
cord-006229-7yoilsho	4232	13	relevance	relevance	NN
cord-006229-7yoilsho	4232	14	of	of	IN
cord-006229-7yoilsho	4232	15	TRH	TRH	NNP
cord-006229-7yoilsho	4232	16	neurons	neuron	NNS
cord-006229-7yoilsho	4232	17	in	in	IN
cord-006229-7yoilsho	4232	18	detail	detail	NN
cord-006229-7yoilsho	4232	19	.	.	.
cord-006229-7yoilsho	4233	1	Background	Background	NNP
cord-006229-7yoilsho	4233	2	&	&	CC
cord-006229-7yoilsho	4233	3	Objective	Objective	NNP
cord-006229-7yoilsho	4233	4	:	:	:
cord-006229-7yoilsho	4233	5	During	during	IN
cord-006229-7yoilsho	4233	6	obesity	obesity	NN
cord-006229-7yoilsho	4233	7	development	development	NN
cord-006229-7yoilsho	4233	8	,	,	,
cord-006229-7yoilsho	4233	9	tissue	tissue	NN
cord-006229-7yoilsho	4233	10	factor	factor	NN
cord-006229-7yoilsho	4233	11	signalling	signalling	NN
cord-006229-7yoilsho	4233	12	contributes	contribute	VBZ
cord-006229-7yoilsho	4233	13	coagulation	coagulation	NN
cord-006229-7yoilsho	4233	14	-	-	:
cord-006229-7yoilsho	4233	15	independently	independently	RB
cord-006229-7yoilsho	4233	16	to	to	IN
cord-006229-7yoilsho	4233	17	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	4233	18	and	and	CC
cord-006229-7yoilsho	4233	19	metabolic	metabolic	JJ
cord-006229-7yoilsho	4233	20	dysfunction	dysfunction	NN
cord-006229-7yoilsho	4233	21	of	of	IN
cord-006229-7yoilsho	4233	22	adipose	adipose	JJ
cord-006229-7yoilsho	4233	23	tissue	tissue	NN
cord-006229-7yoilsho	4233	24	.	.	.
cord-006229-7yoilsho	4234	1	Adipogenesis	adipogenesis	NN
cord-006229-7yoilsho	4234	2	involves	involve	VBZ
cord-006229-7yoilsho	4234	3	proliferation	proliferation	NN
cord-006229-7yoilsho	4234	4	and	and	CC
cord-006229-7yoilsho	4234	5	differentiation	differentiation	NN
cord-006229-7yoilsho	4234	6	of	of	IN
cord-006229-7yoilsho	4234	7	preadipocytes	preadipocyte	NNS
cord-006229-7yoilsho	4234	8	,	,	,
cord-006229-7yoilsho	4234	9	apoptosis	apoptosis	NN
cord-006229-7yoilsho	4234	10	and	and	CC
cord-006229-7yoilsho	4234	11	hypertrophic	hypertrophic	JJ
cord-006229-7yoilsho	4234	12	growth	growth	NN
cord-006229-7yoilsho	4234	13	of	of	IN
cord-006229-7yoilsho	4234	14	differentiated	differentiated	JJ
cord-006229-7yoilsho	4234	15	adipocytes	adipocyte	NNS
cord-006229-7yoilsho	4234	16	,	,	,
cord-006229-7yoilsho	4234	17	angiogenesis	angiogenesis	NN
cord-006229-7yoilsho	4234	18	and	and	CC
cord-006229-7yoilsho	4234	19	extracellular	extracellular	JJ
cord-006229-7yoilsho	4234	20	matrix	matrix	NN
cord-006229-7yoilsho	4234	21	reorganisation	reorganisation	NN
cord-006229-7yoilsho	4234	22	.	.	.
cord-006229-7yoilsho	4235	1	The	the	DT
cord-006229-7yoilsho	4235	2	coagulant	coagulant	NN
cord-006229-7yoilsho	4235	3	protease	protease	NN
cord-006229-7yoilsho	4235	4	thrombin	thrombin	NN
cord-006229-7yoilsho	4235	5	promotes	promote	VBZ
cord-006229-7yoilsho	4235	6	similar	similar	JJ
cord-006229-7yoilsho	4235	7	processes	process	NNS
cord-006229-7yoilsho	4235	8	in	in	IN
cord-006229-7yoilsho	4235	9	various	various	JJ
cord-006229-7yoilsho	4235	10	cell	cell	NN
cord-006229-7yoilsho	4235	11	types	type	NNS
cord-006229-7yoilsho	4235	12	,	,	,
cord-006229-7yoilsho	4235	13	through	through	IN
cord-006229-7yoilsho	4235	14	activation	activation	NN
cord-006229-7yoilsho	4235	15	of	of	IN
cord-006229-7yoilsho	4235	16	protease	protease	NN
cord-006229-7yoilsho	4235	17	-	-	HYPH
cord-006229-7yoilsho	4235	18	activated	activate	VBN
cord-006229-7yoilsho	4235	19	receptors	receptor	NNS
cord-006229-7yoilsho	4235	20	PAR-1	PAR-1	NNP
cord-006229-7yoilsho	4235	21	,	,	,
cord-006229-7yoilsho	4235	22	PAR-3	PAR-3	NNP
cord-006229-7yoilsho	4236	1	and	and	CC
cord-006229-7yoilsho	4236	2	PAR-4	PAR-4	NNP
cord-006229-7yoilsho	4236	3	.	.	.
cord-006229-7yoilsho	4237	1	In	in	IN
cord-006229-7yoilsho	4237	2	human	human	JJ
cord-006229-7yoilsho	4237	3	adipose	adipose	JJ
cord-006229-7yoilsho	4237	4	tissue	tissue	NN
cord-006229-7yoilsho	4237	5	,	,	,
cord-006229-7yoilsho	4237	6	PAR-1	PAR-1	NNP
cord-006229-7yoilsho	4237	7	is	be	VBZ
cord-006229-7yoilsho	4237	8	found	find	VBN
cord-006229-7yoilsho	4237	9	in	in	IN
cord-006229-7yoilsho	4237	10	vascular	vascular	JJ
cord-006229-7yoilsho	4237	11	stromal	stromal	JJ
cord-006229-7yoilsho	4237	12	cells	cell	NNS
cord-006229-7yoilsho	4237	13	and	and	CC
cord-006229-7yoilsho	4237	14	PAR-4	PAR-4	NNP
cord-006229-7yoilsho	4237	15	in	in	IN
cord-006229-7yoilsho	4237	16	preadipocytes	preadipocytes	NNP
cord-006229-7yoilsho	4237	17	and	and	CC
cord-006229-7yoilsho	4237	18	differentiated	differentiated	JJ
cord-006229-7yoilsho	4237	19	adipocytes	adipocyte	NNS
cord-006229-7yoilsho	4237	20	.	.	.
cord-006229-7yoilsho	4238	1	Thrombin	Thrombin	NNP
cord-006229-7yoilsho	4238	2	stimulates	stimulate	VBZ
cord-006229-7yoilsho	4238	3	mitogenic	mitogenic	NNP
cord-006229-7yoilsho	4238	4	kinase	kinase	VBZ
cord-006229-7yoilsho	4238	5	signalling	signal	VBG
cord-006229-7yoilsho	4238	6	and	and	CC
cord-006229-7yoilsho	4238	7	induces	induce	VBZ
cord-006229-7yoilsho	4238	8	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	4238	9	cytokine	cytokine	NN
cord-006229-7yoilsho	4238	10	and	and	CC
cord-006229-7yoilsho	4238	11	angiogenic	angiogenic	JJ
cord-006229-7yoilsho	4238	12	growth	growth	NN
cord-006229-7yoilsho	4238	13	factor	factor	NN
cord-006229-7yoilsho	4238	14	secretion	secretion	NN
cord-006229-7yoilsho	4238	15	in	in	IN
cord-006229-7yoilsho	4238	16	adipocytes	adipocyte	NNS
cord-006229-7yoilsho	4238	17	.	.	.
cord-006229-7yoilsho	4239	1	We	-PRON-	PRP
cord-006229-7yoilsho	4239	2	have	have	VBP
cord-006229-7yoilsho	4239	3	examined	examine	VBN
cord-006229-7yoilsho	4239	4	the	the	DT
cord-006229-7yoilsho	4239	5	contribution	contribution	NN
cord-006229-7yoilsho	4239	6	of	of	IN
cord-006229-7yoilsho	4239	7	thrombin	thrombin	JJ
cord-006229-7yoilsho	4239	8	receptor	receptor	NN
cord-006229-7yoilsho	4239	9	activation	activation	NN
cord-006229-7yoilsho	4239	10	to	to	IN
cord-006229-7yoilsho	4239	11	adipogenesis	adipogenesis	NN
cord-006229-7yoilsho	4239	12	processes	process	NNS
cord-006229-7yoilsho	4239	13	in	in	IN
cord-006229-7yoilsho	4239	14	3T3L1	3t3l1	CD
cord-006229-7yoilsho	4239	15	cells	cell	NNS
cord-006229-7yoilsho	4239	16	.	.	.
cord-006229-7yoilsho	4240	1	Results	result	NNS
cord-006229-7yoilsho	4240	2	:	:	:
cord-006229-7yoilsho	4241	1	Differentiation	differentiation	NN
cord-006229-7yoilsho	4241	2	of	of	IN
cord-006229-7yoilsho	4241	3	3T3L1	3T3L1	NNP
cord-006229-7yoilsho	4241	4	preadipocytes	preadipocyte	NNS
cord-006229-7yoilsho	4241	5	with	with	IN
cord-006229-7yoilsho	4241	6	insulin	insulin	NN
cord-006229-7yoilsho	4241	7	,	,	,
cord-006229-7yoilsho	4241	8	dexamethasone	dexamethasone	NN
cord-006229-7yoilsho	4241	9	and	and	CC
cord-006229-7yoilsho	4241	10	isobutylmethylxanthine	isobutylmethylxanthine	NN
cord-006229-7yoilsho	4241	11	increases	increase	VBZ
cord-006229-7yoilsho	4241	12	leptin	leptin	NN
cord-006229-7yoilsho	4241	13	and	and	CC
cord-006229-7yoilsho	4241	14	PPARg	PPARg	NNS
cord-006229-7yoilsho	4241	15	gene	gene	NN
cord-006229-7yoilsho	4241	16	expression	expression	NN
cord-006229-7yoilsho	4241	17	and	and	CC
cord-006229-7yoilsho	4241	18	accumulation	accumulation	NN
cord-006229-7yoilsho	4241	19	of	of	IN
cord-006229-7yoilsho	4241	20	triglycerides	triglyceride	NNS
cord-006229-7yoilsho	4241	21	and	and	CC
cord-006229-7yoilsho	4241	22	oil	oil	NN
cord-006229-7yoilsho	4241	23	red	red	JJ
cord-006229-7yoilsho	4241	24	O	o	NN
cord-006229-7yoilsho	4241	25	-	-	HYPH
cord-006229-7yoilsho	4241	26	stained	stain	VBN
cord-006229-7yoilsho	4241	27	lipids	lipid	NNS
cord-006229-7yoilsho	4241	28	.	.	.
cord-006229-7yoilsho	4242	1	PAR-4	PAR-4	NNP
cord-006229-7yoilsho	4242	2	is	be	VBZ
cord-006229-7yoilsho	4242	3	time	time	NN
cord-006229-7yoilsho	4242	4	-	-	:
cord-006229-7yoilsho	4242	5	dependently	dependently	RB
cord-006229-7yoilsho	4242	6	upregulated	upregulate	VBN
cord-006229-7yoilsho	4242	7	in	in	IN
cord-006229-7yoilsho	4242	8	maturing	mature	VBG
cord-006229-7yoilsho	4242	9	cells	cell	NNS
cord-006229-7yoilsho	4242	10	while	while	IN
cord-006229-7yoilsho	4242	11	PAR-1	PAR-1	NNP
cord-006229-7yoilsho	4242	12	expression	expression	NN
cord-006229-7yoilsho	4242	13	is	be	VBZ
cord-006229-7yoilsho	4242	14	detectable	detectable	JJ
cord-006229-7yoilsho	4242	15	but	but	CC
cord-006229-7yoilsho	4242	16	not	not	RB
cord-006229-7yoilsho	4242	17	altered	alter	VBN
cord-006229-7yoilsho	4242	18	.	.	.
cord-006229-7yoilsho	4243	1	In	in	IN
cord-006229-7yoilsho	4243	2	preadipocytes	preadipocyte	NNS
cord-006229-7yoilsho	4243	3	,	,	,
cord-006229-7yoilsho	4243	4	thrombin	thrombin	NN
cord-006229-7yoilsho	4243	5	(	(	-LRB-
cord-006229-7yoilsho	4243	6	3	3	CD
cord-006229-7yoilsho	4243	7	U	u	NN
cord-006229-7yoilsho	4243	8	/	/	SYM
cord-006229-7yoilsho	4243	9	mL	ml	NN
cord-006229-7yoilsho	4243	10	)	)	-RRB-
cord-006229-7yoilsho	4243	11	activates	activate	VBZ
cord-006229-7yoilsho	4243	12	the	the	DT
cord-006229-7yoilsho	4243	13	mitogenic	mitogenic	NNP
cord-006229-7yoilsho	4243	14	kinase	kinase	NNP
cord-006229-7yoilsho	4243	15	ERK1/2	ERK1/2	NNP
cord-006229-7yoilsho	4243	16	,	,	,
cord-006229-7yoilsho	4243	17	promotes	promote	VBZ
cord-006229-7yoilsho	4243	18	cell	cell	NN
cord-006229-7yoilsho	4243	19	proliferation	proliferation	NN
cord-006229-7yoilsho	4243	20	and	and	CC
cord-006229-7yoilsho	4243	21	induces	induce	VBZ
cord-006229-7yoilsho	4243	22	gene	gene	NN
cord-006229-7yoilsho	4243	23	expression	expression	NN
cord-006229-7yoilsho	4243	24	of	of	IN
cord-006229-7yoilsho	4243	25	the	the	DT
cord-006229-7yoilsho	4243	26	maturation	maturation	NN
cord-006229-7yoilsho	4243	27	markers	marker	VBZ
cord-006229-7yoilsho	4243	28	leptin	leptin	NNS
cord-006229-7yoilsho	4243	29	and	and	CC
cord-006229-7yoilsho	4243	30	PPARg	PPARg	NNS
cord-006229-7yoilsho	4243	31	and	and	CC
cord-006229-7yoilsho	4243	32	the	the	DT
cord-006229-7yoilsho	4243	33	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	4243	34	marker	marker	NN
cord-006229-7yoilsho	4243	35	tumor	tumor	NN
cord-006229-7yoilsho	4243	36	necrosis	necrosis	NN
cord-006229-7yoilsho	4243	37	factor	factor	NN
cord-006229-7yoilsho	4243	38	alpha	alpha	NN
cord-006229-7yoilsho	4243	39	(	(	-LRB-
cord-006229-7yoilsho	4243	40	TNFa	TNFa	NNP
cord-006229-7yoilsho	4243	41	)	)	-RRB-
cord-006229-7yoilsho	4243	42	.	.	.
cord-006229-7yoilsho	4244	1	Repeated	repeat	VBN
cord-006229-7yoilsho	4244	2	stimulation	stimulation	NN
cord-006229-7yoilsho	4244	3	of	of	IN
cord-006229-7yoilsho	4244	4	differentiating	differentiate	VBG
cord-006229-7yoilsho	4244	5	adipocytes	adipocyte	NNS
cord-006229-7yoilsho	4244	6	with	with	IN
cord-006229-7yoilsho	4244	7	thrombin	thrombin	NN
cord-006229-7yoilsho	4244	8	suppresses	suppress	VBZ
cord-006229-7yoilsho	4244	9	induction	induction	NN
cord-006229-7yoilsho	4244	10	of	of	IN
cord-006229-7yoilsho	4244	11	leptin	leptin	NN
cord-006229-7yoilsho	4244	12	and	and	CC
cord-006229-7yoilsho	4244	13	PPARg	PPARg	NNS
cord-006229-7yoilsho	4244	14	and	and	CC
cord-006229-7yoilsho	4244	15	attenuates	attenuate	VBZ
cord-006229-7yoilsho	4244	16	lipid	lipid	NN
cord-006229-7yoilsho	4244	17	accumulation	accumulation	NN
cord-006229-7yoilsho	4244	18	,	,	,
cord-006229-7yoilsho	4244	19	while	while	IN
cord-006229-7yoilsho	4244	20	expression	expression	NN
cord-006229-7yoilsho	4244	21	levels	level	NNS
cord-006229-7yoilsho	4244	22	of	of	IN
cord-006229-7yoilsho	4244	23	the	the	DT
cord-006229-7yoilsho	4244	24	proliferation	proliferation	NN
cord-006229-7yoilsho	4244	25	marker	marker	NN
cord-006229-7yoilsho	4244	26	Ki67	Ki67	NNP
cord-006229-7yoilsho	4244	27	and	and	CC
cord-006229-7yoilsho	4244	28	the	the	DT
cord-006229-7yoilsho	4244	29	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	4244	30	cytokine	cytokine	NN
cord-006229-7yoilsho	4244	31	interleukin	interleukin	NN
cord-006229-7yoilsho	4244	32	(	(	-LRB-
cord-006229-7yoilsho	4244	33	IL)-6	IL)-6	NNP
cord-006229-7yoilsho	4244	34	are	be	VBP
cord-006229-7yoilsho	4244	35	increased	increase	VBN
cord-006229-7yoilsho	4244	36	compared	compare	VBN
cord-006229-7yoilsho	4244	37	to	to	IN
cord-006229-7yoilsho	4244	38	differentiated	differentiated	JJ
cord-006229-7yoilsho	4244	39	control	control	NN
cord-006229-7yoilsho	4244	40	cells	cell	NNS
cord-006229-7yoilsho	4244	41	.	.	.
cord-006229-7yoilsho	4245	1	Similar	similar	JJ
cord-006229-7yoilsho	4245	2	proliferative	proliferative	JJ
cord-006229-7yoilsho	4245	3	and	and	CC
cord-006229-7yoilsho	4245	4	anti	anti	JJ
cord-006229-7yoilsho	4245	5	-	-	JJ
cord-006229-7yoilsho	4245	6	adipogenic	adipogenic	JJ
cord-006229-7yoilsho	4245	7	effects	effect	NNS
cord-006229-7yoilsho	4245	8	are	be	VBP
cord-006229-7yoilsho	4245	9	seen	see	VBN
cord-006229-7yoilsho	4245	10	with	with	IN
cord-006229-7yoilsho	4245	11	the	the	DT
cord-006229-7yoilsho	4245	12	selective	selective	JJ
cord-006229-7yoilsho	4245	13	PAR4-activating	par4-activating	NN
cord-006229-7yoilsho	4245	14	peptide	peptide	NN
cord-006229-7yoilsho	4245	15	(	(	-LRB-
cord-006229-7yoilsho	4245	16	GYPGKF	GYPGKF	NNP
cord-006229-7yoilsho	4245	17	,	,	,
cord-006229-7yoilsho	4245	18	100	100	CD
cord-006229-7yoilsho	4245	19	µM	µM	NNS
cord-006229-7yoilsho	4245	20	)	)	-RRB-
cord-006229-7yoilsho	4245	21	and	and	CC
cord-006229-7yoilsho	4245	22	cathepsin	cathepsin	NN
cord-006229-7yoilsho	4245	23	G	g	NN
cord-006229-7yoilsho	4245	24	,	,	,
cord-006229-7yoilsho	4245	25	a	a	DT
cord-006229-7yoilsho	4245	26	proteolytic	proteolytic	JJ
cord-006229-7yoilsho	4245	27	PAR-4	PAR-4	NNP
cord-006229-7yoilsho	4245	28	activator	activator	NN
cord-006229-7yoilsho	4245	29	released	release	VBN
cord-006229-7yoilsho	4245	30	from	from	IN
cord-006229-7yoilsho	4245	31	neutrophils	neutrophil	NNS
cord-006229-7yoilsho	4245	32	and	and	CC
cord-006229-7yoilsho	4245	33	mast	mast	NN
cord-006229-7yoilsho	4245	34	cells	cell	NNS
cord-006229-7yoilsho	4245	35	.	.	.
cord-006229-7yoilsho	4246	1	Repeated	repeat	VBN
cord-006229-7yoilsho	4246	2	exposure	exposure	NN
cord-006229-7yoilsho	4246	3	of	of	IN
cord-006229-7yoilsho	4246	4	maturing	mature	VBG
cord-006229-7yoilsho	4246	5	3T3L1	3t3l1	CD
cord-006229-7yoilsho	4246	6	cells	cell	NNS
cord-006229-7yoilsho	4246	7	to	to	IN
cord-006229-7yoilsho	4246	8	conditioned	condition	VBN
cord-006229-7yoilsho	4246	9	medium	medium	NN
cord-006229-7yoilsho	4246	10	from	from	IN
cord-006229-7yoilsho	4246	11	degranulating	degranulate	VBG
cord-006229-7yoilsho	4246	12	mouse	mouse	NN
cord-006229-7yoilsho	4246	13	peritoneal	peritoneal	NN
cord-006229-7yoilsho	4246	14	mast	mast	NN
cord-006229-7yoilsho	4246	15	cells	cell	NNS
cord-006229-7yoilsho	4246	16	(	(	-LRB-
cord-006229-7yoilsho	4246	17	MCCM	MCCM	NNS
cord-006229-7yoilsho	4246	18	)	)	-RRB-
cord-006229-7yoilsho	4246	19	augments	augment	VBZ
cord-006229-7yoilsho	4246	20	lipid	lipid	NN
cord-006229-7yoilsho	4246	21	accumulation	accumulation	NN
cord-006229-7yoilsho	4246	22	and	and	CC
cord-006229-7yoilsho	4246	23	IL-6	IL-6	NNP
cord-006229-7yoilsho	4246	24	expression	expression	NN
cord-006229-7yoilsho	4246	25	.	.	.
cord-006229-7yoilsho	4247	1	Pretreatment	pretreatment	NN
cord-006229-7yoilsho	4247	2	of	of	IN
cord-006229-7yoilsho	4247	3	MCCM	MCCM	NNS
cord-006229-7yoilsho	4247	4	with	with	IN
cord-006229-7yoilsho	4247	5	a	a	DT
cord-006229-7yoilsho	4247	6	PAR-4	PAR-4	NNP
cord-006229-7yoilsho	4247	7	inhibitor	inhibitor	NN
cord-006229-7yoilsho	4247	8	further	far	RBR
cord-006229-7yoilsho	4247	9	drives	drive	VBZ
cord-006229-7yoilsho	4247	10	lipid	lipid	NN
cord-006229-7yoilsho	4247	11	accumulation	accumulation	NN
cord-006229-7yoilsho	4247	12	,	,	,
cord-006229-7yoilsho	4247	13	the	the	DT
cord-006229-7yoilsho	4247	14	induction	induction	NN
cord-006229-7yoilsho	4247	15	of	of	IN
cord-006229-7yoilsho	4247	16	IL-6	IL-6	NNP
cord-006229-7yoilsho	4247	17	by	by	IN
cord-006229-7yoilsho	4247	18	contrast	contrast	NN
cord-006229-7yoilsho	4247	19	is	be	VBZ
cord-006229-7yoilsho	4247	20	suppressed	suppress	VBN
cord-006229-7yoilsho	4247	21	.	.	.
cord-006229-7yoilsho	4248	1	Conclusion	conclusion	NN
cord-006229-7yoilsho	4248	2	:	:	:
cord-006229-7yoilsho	4249	1	PAR-4	PAR-4	NNP
cord-006229-7yoilsho	4249	2	activation	activation	NN
cord-006229-7yoilsho	4249	3	by	by	IN
cord-006229-7yoilsho	4249	4	thrombin	thrombin	JJ
cord-006229-7yoilsho	4249	5	or	or	CC
cord-006229-7yoilsho	4249	6	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	4249	7	cell	cell	NN
cord-006229-7yoilsho	4249	8	-	-	HYPH
cord-006229-7yoilsho	4249	9	derived	derive	VBN
cord-006229-7yoilsho	4249	10	cathepsin	cathepsin	NN
cord-006229-7yoilsho	4249	11	G	g	NN
cord-006229-7yoilsho	4249	12	appears	appear	VBZ
cord-006229-7yoilsho	4249	13	to	to	TO
cord-006229-7yoilsho	4249	14	suppress	suppress	VB
cord-006229-7yoilsho	4249	15	adipogenesis	adipogenesis	NN
cord-006229-7yoilsho	4249	16	,	,	,
cord-006229-7yoilsho	4249	17	possibly	possibly	RB
cord-006229-7yoilsho	4249	18	by	by	IN
cord-006229-7yoilsho	4249	19	maintaining	maintain	VBG
cord-006229-7yoilsho	4249	20	proliferative	proliferative	JJ
cord-006229-7yoilsho	4249	21	capacity	capacity	NN
cord-006229-7yoilsho	4249	22	and	and	CC
cord-006229-7yoilsho	4249	23	preventing	prevent	VBG
cord-006229-7yoilsho	4249	24	the	the	DT
cord-006229-7yoilsho	4249	25	growth	growth	NN
cord-006229-7yoilsho	4249	26	arrest	arrest	NN
cord-006229-7yoilsho	4249	27	essential	essential	JJ
cord-006229-7yoilsho	4249	28	for	for	IN
cord-006229-7yoilsho	4249	29	initiating	initiate	VBG
cord-006229-7yoilsho	4249	30	matuation	matuation	NN
cord-006229-7yoilsho	4249	31	.	.	.
cord-006229-7yoilsho	4250	1	Increased	increase	VBN
cord-006229-7yoilsho	4250	2	PAR-4	PAR-4	NNP
cord-006229-7yoilsho	4250	3	expression	expression	NN
cord-006229-7yoilsho	4250	4	in	in	IN
cord-006229-7yoilsho	4250	5	maturing	mature	VBG
cord-006229-7yoilsho	4250	6	adipocytes	adipocyte	NNS
cord-006229-7yoilsho	4250	7	may	may	MD
cord-006229-7yoilsho	4250	8	instead	instead	RB
cord-006229-7yoilsho	4250	9	support	support	VB
cord-006229-7yoilsho	4250	10	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	4250	11	changes	change	NNS
cord-006229-7yoilsho	4250	12	,	,	,
cord-006229-7yoilsho	4250	13	thereby	thereby	RB
cord-006229-7yoilsho	4250	14	promoting	promote	VBG
cord-006229-7yoilsho	4250	15	the	the	DT
cord-006229-7yoilsho	4250	16	onset	onset	NN
cord-006229-7yoilsho	4250	17	of	of	IN
cord-006229-7yoilsho	4250	18	insulin	insulin	NN
cord-006229-7yoilsho	4250	19	resistance	resistance	NN
cord-006229-7yoilsho	4250	20	.	.	.
cord-006229-7yoilsho	4251	1	The	the	DT
cord-006229-7yoilsho	4251	2	chemokine	chemokine	NN
cord-006229-7yoilsho	4251	3	receptor	receptor	NN
cord-006229-7yoilsho	4251	4	CXCR4	CXCR4	NNP
cord-006229-7yoilsho	4251	5	antagonist	antagonist	NN
cord-006229-7yoilsho	4252	1	AMD3100	AMD3100	NNP
cord-006229-7yoilsho	4252	2	exerts	exert	VBZ
cord-006229-7yoilsho	4252	3	deleterious	deleterious	JJ
cord-006229-7yoilsho	4252	4	effects	effect	NNS
cord-006229-7yoilsho	4252	5	in	in	IN
cord-006229-7yoilsho	4252	6	endotoxemia	endotoxemia	NN
cord-006229-7yoilsho	4252	7	in	in	IN
cord-006229-7yoilsho	4252	8	vivo	vivo	NNP
cord-006229-7yoilsho	4252	9	S.	S.	NNP
cord-006229-7yoilsho	4252	10	Seemann	Seemann	NNP
cord-006229-7yoilsho	4252	11	1	1	CD
cord-006229-7yoilsho	4252	12	,	,	,
cord-006229-7yoilsho	4252	13	A.	A.	NNP
cord-006229-7yoilsho	4252	14	Lupp	Lupp	NNP
cord-006229-7yoilsho	4253	1	The	the	DT
cord-006229-7yoilsho	4253	2	chemokine	chemokine	NN
cord-006229-7yoilsho	4253	3	receptor	receptor	NN
cord-006229-7yoilsho	4253	4	CXCR4	cxcr4	NN
cord-006229-7yoilsho	4253	5	is	be	VBZ
cord-006229-7yoilsho	4253	6	a	a	DT
cord-006229-7yoilsho	4253	7	multifunctional	multifunctional	JJ
cord-006229-7yoilsho	4253	8	receptor	receptor	NN
cord-006229-7yoilsho	4253	9	which	which	WDT
cord-006229-7yoilsho	4253	10	is	be	VBZ
cord-006229-7yoilsho	4253	11	activated	activate	VBN
cord-006229-7yoilsho	4253	12	by	by	IN
cord-006229-7yoilsho	4253	13	its	-PRON-	PRP$
cord-006229-7yoilsho	4253	14	natural	natural	JJ
cord-006229-7yoilsho	4253	15	ligand	ligand	NN
cord-006229-7yoilsho	4253	16	C	c	NN
cord-006229-7yoilsho	4253	17	-	-	HYPH
cord-006229-7yoilsho	4253	18	X	X	NNP
cord-006229-7yoilsho	4253	19	-	-	HYPH
cord-006229-7yoilsho	4253	20	C	c	NN
cord-006229-7yoilsho	4253	21	motif	motif	NN
cord-006229-7yoilsho	4253	22	chemokine	chemokine	NN
cord-006229-7yoilsho	4253	23	12	12	CD
cord-006229-7yoilsho	4253	24	(	(	-LRB-
cord-006229-7yoilsho	4253	25	CXCL12	CXCL12	NNP
cord-006229-7yoilsho	4253	26	)	)	-RRB-
cord-006229-7yoilsho	4253	27	.	.	.
cord-006229-7yoilsho	4254	1	Although	although	IN
cord-006229-7yoilsho	4254	2	a	a	DT
cord-006229-7yoilsho	4254	3	blockade	blockade	NN
cord-006229-7yoilsho	4254	4	of	of	IN
cord-006229-7yoilsho	4254	5	the	the	DT
cord-006229-7yoilsho	4254	6	CXCR4	CXCR4	NNP
cord-006229-7yoilsho	4254	7	/	/	SYM
cord-006229-7yoilsho	4254	8	CXCL12	CXCL12	NNP
cord-006229-7yoilsho	4254	9	axis	axis	NN
cord-006229-7yoilsho	4254	10	revealed	reveal	VBD
cord-006229-7yoilsho	4254	11	beneficial	beneficial	JJ
cord-006229-7yoilsho	4254	12	outcomes	outcome	NNS
cord-006229-7yoilsho	4254	13	in	in	IN
cord-006229-7yoilsho	4254	14	chronic	chronic	JJ
cord-006229-7yoilsho	4254	15	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	4254	16	diseases	disease	NNS
cord-006229-7yoilsho	4254	17	,	,	,
cord-006229-7yoilsho	4254	18	its	-PRON-	PRP$
cord-006229-7yoilsho	4254	19	importance	importance	NN
cord-006229-7yoilsho	4254	20	in	in	IN
cord-006229-7yoilsho	4254	21	acute	acute	JJ
cord-006229-7yoilsho	4254	22	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	4254	23	diseases	disease	NNS
cord-006229-7yoilsho	4254	24	remains	remain	VBZ
cord-006229-7yoilsho	4254	25	contradictious	contradictious	JJ
cord-006229-7yoilsho	4254	26	and	and	CC
cord-006229-7yoilsho	4254	27	not	not	RB
cord-006229-7yoilsho	4254	28	well	well	RB
cord-006229-7yoilsho	4254	29	characterized	characterize	VBN
cord-006229-7yoilsho	4254	30	.	.	.
cord-006229-7yoilsho	4255	1	As	as	IN
cord-006229-7yoilsho	4255	2	CXCR4	CXCR4	NNP
cord-006229-7yoilsho	4255	3	seems	seem	VBZ
cord-006229-7yoilsho	4255	4	to	to	TO
cord-006229-7yoilsho	4255	5	be	be	VB
cord-006229-7yoilsho	4255	6	part	part	NN
cord-006229-7yoilsho	4255	7	of	of	IN
cord-006229-7yoilsho	4255	8	the	the	DT
cord-006229-7yoilsho	4255	9	lipopolysaccharide	lipopolysaccharide	NN
cord-006229-7yoilsho	4255	10	sensing	sensing	NN
cord-006229-7yoilsho	4255	11	complex	complex	NN
cord-006229-7yoilsho	4255	12	,	,	,
cord-006229-7yoilsho	4255	13	CXCR4	CXCR4	NNS
cord-006229-7yoilsho	4255	14	agonists	agonist	NNS
cord-006229-7yoilsho	4255	15	or	or	CC
cord-006229-7yoilsho	4255	16	antagonists	antagonist	NNS
cord-006229-7yoilsho	4255	17	may	may	MD
cord-006229-7yoilsho	4255	18	have	have	VB
cord-006229-7yoilsho	4255	19	a	a	DT
cord-006229-7yoilsho	4255	20	positive	positive	JJ
cord-006229-7yoilsho	4255	21	impact	impact	NN
cord-006229-7yoilsho	4255	22	on	on	IN
cord-006229-7yoilsho	4255	23	TLR4	TLR4	NNP
cord-006229-7yoilsho	4255	24	signaling	signaling	NN
cord-006229-7yoilsho	4255	25	.	.	.
cord-006229-7yoilsho	4256	1	Additionally	additionally	RB
cord-006229-7yoilsho	4256	2	,	,	,
cord-006229-7yoilsho	4256	3	CXCR4	CXCR4	NNP
cord-006229-7yoilsho	4256	4	is	be	VBZ
cord-006229-7yoilsho	4256	5	involved	involve	VBN
cord-006229-7yoilsho	4256	6	in	in	IN
cord-006229-7yoilsho	4256	7	the	the	DT
cord-006229-7yoilsho	4256	8	production	production	NN
cord-006229-7yoilsho	4256	9	of	of	IN
cord-006229-7yoilsho	4256	10	pro	pro	JJ
cord-006229-7yoilsho	4256	11	-	-	JJ
cord-006229-7yoilsho	4256	12	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	4256	13	cytokines	cytokine	NNS
cord-006229-7yoilsho	4256	14	,	,	,
cord-006229-7yoilsho	4256	15	suggesting	suggest	VBG
cord-006229-7yoilsho	4256	16	the	the	DT
cord-006229-7yoilsho	4256	17	receptor	receptor	NN
cord-006229-7yoilsho	4256	18	to	to	TO
cord-006229-7yoilsho	4256	19	be	be	VB
cord-006229-7yoilsho	4256	20	a	a	DT
cord-006229-7yoilsho	4256	21	promising	promising	JJ
cord-006229-7yoilsho	4256	22	target	target	NN
cord-006229-7yoilsho	4256	23	in	in	IN
cord-006229-7yoilsho	4256	24	terms	term	NNS
cord-006229-7yoilsho	4256	25	of	of	IN
cord-006229-7yoilsho	4256	26	mitigating	mitigate	VBG
cord-006229-7yoilsho	4256	27	the	the	DT
cord-006229-7yoilsho	4256	28	cytokine	cytokine	NN
cord-006229-7yoilsho	4256	29	storm	storm	NN
cord-006229-7yoilsho	4256	30	.	.	.
cord-006229-7yoilsho	4257	1	Therefore	therefore	RB
cord-006229-7yoilsho	4257	2	,	,	,
cord-006229-7yoilsho	4257	3	we	-PRON-	PRP
cord-006229-7yoilsho	4257	4	aimed	aim	VBD
cord-006229-7yoilsho	4257	5	to	to	TO
cord-006229-7yoilsho	4257	6	investigate	investigate	VB
cord-006229-7yoilsho	4257	7	the	the	DT
cord-006229-7yoilsho	4257	8	impact	impact	NN
cord-006229-7yoilsho	4257	9	of	of	IN
cord-006229-7yoilsho	4257	10	a	a	DT
cord-006229-7yoilsho	4257	11	CXCR4	cxcr4	NN
cord-006229-7yoilsho	4257	12	blockade	blockade	NN
cord-006229-7yoilsho	4257	13	on	on	IN
cord-006229-7yoilsho	4257	14	endotoxemia	endotoxemia	NN
cord-006229-7yoilsho	4257	15	by	by	IN
cord-006229-7yoilsho	4257	16	applying	apply	VBG
cord-006229-7yoilsho	4257	17	a	a	DT
cord-006229-7yoilsho	4257	18	sublethal	sublethal	JJ
cord-006229-7yoilsho	4257	19	LPS	lp	NNS
cord-006229-7yoilsho	4257	20	dose	dose	NN
cord-006229-7yoilsho	4257	21	(	(	-LRB-
cord-006229-7yoilsho	4257	22	5	5	CD
cord-006229-7yoilsho	4257	23	mg	mg	NN
cord-006229-7yoilsho	4257	24	/	/	SYM
cord-006229-7yoilsho	4257	25	body	body	NN
cord-006229-7yoilsho	4257	26	weight	weight	NN
cord-006229-7yoilsho	4257	27	)	)	-RRB-
cord-006229-7yoilsho	4257	28	in	in	IN
cord-006229-7yoilsho	4257	29	mice	mouse	NNS
cord-006229-7yoilsho	4257	30	.	.	.
cord-006229-7yoilsho	4258	1	The	the	DT
cord-006229-7yoilsho	4258	2	selective	selective	JJ
cord-006229-7yoilsho	4258	3	CXCR4	cxcr4	NN
cord-006229-7yoilsho	4258	4	inhibitor	inhibitor	NN
cord-006229-7yoilsho	4258	5	AMD3100	AMD3100	,
cord-006229-7yoilsho	4258	6	was	be	VBD
cord-006229-7yoilsho	4258	7	administered	administer	VBN
cord-006229-7yoilsho	4258	8	intraperitoneally	intraperitoneally	RB
cord-006229-7yoilsho	4258	9	shortly	shortly	RB
cord-006229-7yoilsho	4258	10	after	after	IN
cord-006229-7yoilsho	4258	11	LPS	LPS	NNP
cord-006229-7yoilsho	4258	12	treatment	treatment	NN
cord-006229-7yoilsho	4258	13	to	to	TO
cord-006229-7yoilsho	4258	14	ensure	ensure	VB
cord-006229-7yoilsho	4258	15	an	an	DT
cord-006229-7yoilsho	4258	16	immediate	immediate	JJ
cord-006229-7yoilsho	4258	17	effect	effect	NN
cord-006229-7yoilsho	4258	18	after	after	IN
cord-006229-7yoilsho	4258	19	endotoxemia	endotoxemia	NN
cord-006229-7yoilsho	4258	20	onset	onset	NN
cord-006229-7yoilsho	4258	21	.	.	.
cord-006229-7yoilsho	4259	1	24	24	CD
cord-006229-7yoilsho	4259	2	hours	hour	NNS
cord-006229-7yoilsho	4259	3	after	after	IN
cord-006229-7yoilsho	4259	4	LPS	LPS	NNP
cord-006229-7yoilsho	4259	5	administration	administration	NN
cord-006229-7yoilsho	4259	6	,	,	,
cord-006229-7yoilsho	4259	7	the	the	DT
cord-006229-7yoilsho	4259	8	clinical	clinical	JJ
cord-006229-7yoilsho	4259	9	severity	severity	NN
cord-006229-7yoilsho	4259	10	score	score	NN
cord-006229-7yoilsho	4259	11	,	,	,
cord-006229-7yoilsho	4259	12	the	the	DT
cord-006229-7yoilsho	4259	13	body	body	NN
cord-006229-7yoilsho	4259	14	temperature	temperature	NN
cord-006229-7yoilsho	4259	15	and	and	CC
cord-006229-7yoilsho	4259	16	the	the	DT
cord-006229-7yoilsho	4259	17	body	body	NN
cord-006229-7yoilsho	4259	18	weight	weight	NN
cord-006229-7yoilsho	4259	19	of	of	IN
cord-006229-7yoilsho	4259	20	the	the	DT
cord-006229-7yoilsho	4259	21	animals	animal	NNS
cord-006229-7yoilsho	4259	22	were	be	VBD
cord-006229-7yoilsho	4259	23	determined	determine	VBN
cord-006229-7yoilsho	4259	24	.	.	.
cord-006229-7yoilsho	4260	1	Afterwards	afterwards	RB
cord-006229-7yoilsho	4260	2	,	,	,
cord-006229-7yoilsho	4260	3	the	the	DT
cord-006229-7yoilsho	4260	4	mice	mouse	NNS
cord-006229-7yoilsho	4260	5	were	be	VBD
cord-006229-7yoilsho	4260	6	sacrificed	sacrifice	VBN
cord-006229-7yoilsho	4260	7	and	and	CC
cord-006229-7yoilsho	4260	8	serum	serum	NN
cord-006229-7yoilsho	4260	9	TNF	TNF	NNP
cord-006229-7yoilsho	4260	10	alpha	alpha	NN
cord-006229-7yoilsho	4260	11	as	as	RB
cord-006229-7yoilsho	4260	12	well	well	RB
cord-006229-7yoilsho	4260	13	as	as	IN
cord-006229-7yoilsho	4260	14	IFN	IFN	NNP
cord-006229-7yoilsho	4260	15	gamma	gamma	NN
cord-006229-7yoilsho	4260	16	levels	level	NNS
cord-006229-7yoilsho	4260	17	were	be	VBD
cord-006229-7yoilsho	4260	18	measured	measure	VBN
cord-006229-7yoilsho	4260	19	.	.	.
cord-006229-7yoilsho	4261	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	4261	2	,	,	,
cord-006229-7yoilsho	4261	3	the	the	DT
cord-006229-7yoilsho	4261	4	oxidative	oxidative	JJ
cord-006229-7yoilsho	4261	5	stress	stress	NN
cord-006229-7yoilsho	4261	6	in	in	IN
cord-006229-7yoilsho	4261	7	the	the	DT
cord-006229-7yoilsho	4261	8	brain	brain	NN
cord-006229-7yoilsho	4261	9	,	,	,
cord-006229-7yoilsho	4261	10	liver	liver	NN
cord-006229-7yoilsho	4261	11	,	,	,
cord-006229-7yoilsho	4261	12	lung	lung	NN
cord-006229-7yoilsho	4261	13	and	and	CC
cord-006229-7yoilsho	4261	14	kidney	kidney	NN
cord-006229-7yoilsho	4261	15	tissue	tissue	NN
cord-006229-7yoilsho	4261	16	was	be	VBD
cord-006229-7yoilsho	4261	17	assessed	assess	VBN
cord-006229-7yoilsho	4261	18	.	.	.
cord-006229-7yoilsho	4262	1	In	in	IN
cord-006229-7yoilsho	4262	2	addition	addition	NN
cord-006229-7yoilsho	4262	3	,	,	,
cord-006229-7yoilsho	4262	4	the	the	DT
cord-006229-7yoilsho	4262	5	biotransformation	biotransformation	NN
cord-006229-7yoilsho	4262	6	capacity	capacity	NN
cord-006229-7yoilsho	4262	7	of	of	IN
cord-006229-7yoilsho	4262	8	the	the	DT
cord-006229-7yoilsho	4262	9	liver	liver	NN
cord-006229-7yoilsho	4262	10	was	be	VBD
cord-006229-7yoilsho	4262	11	evaluated	evaluate	VBN
cord-006229-7yoilsho	4262	12	and	and	CC
cord-006229-7yoilsho	4262	13	finally	finally	RB
cord-006229-7yoilsho	4262	14	,	,	,
cord-006229-7yoilsho	4262	15	the	the	DT
cord-006229-7yoilsho	4262	16	expression	expression	NN
cord-006229-7yoilsho	4262	17	of	of	IN
cord-006229-7yoilsho	4262	18	gp91	gp91	NNP
cord-006229-7yoilsho	4262	19	phox	phox	NNP
cord-006229-7yoilsho	4262	20	as	as	RB
cord-006229-7yoilsho	4262	21	well	well	RB
cord-006229-7yoilsho	4262	22	as	as	IN
cord-006229-7yoilsho	4262	23	of	of	IN
cord-006229-7yoilsho	4262	24	heme	heme	NN
cord-006229-7yoilsho	4262	25	oxygenase	oxygenase	NN
cord-006229-7yoilsho	4262	26	1	1	CD
cord-006229-7yoilsho	4262	27	in	in	IN
cord-006229-7yoilsho	4262	28	the	the	DT
cord-006229-7yoilsho	4262	29	spleen	spleen	NN
cord-006229-7yoilsho	4262	30	and	and	CC
cord-006229-7yoilsho	4262	31	liver	liver	NN
cord-006229-7yoilsho	4262	32	were	be	VBD
cord-006229-7yoilsho	4262	33	determined	determine	VBN
cord-006229-7yoilsho	4262	34	by	by	IN
cord-006229-7yoilsho	4262	35	means	mean	NNS
cord-006229-7yoilsho	4262	36	of	of	IN
cord-006229-7yoilsho	4262	37	immunohistochemistry	immunohistochemistry	NN
cord-006229-7yoilsho	4262	38	.	.	.
cord-006229-7yoilsho	4263	1	The	the	DT
cord-006229-7yoilsho	4263	2	mice	mouse	NNS
cord-006229-7yoilsho	4263	3	of	of	IN
cord-006229-7yoilsho	4263	4	the	the	DT
cord-006229-7yoilsho	4263	5	AMD3100	AMD3100	NNS
cord-006229-7yoilsho	4263	6	plus	plus	CC
cord-006229-7yoilsho	4263	7	LPS	LPS	NNP
cord-006229-7yoilsho	4263	8	treatment	treatment	NN
cord-006229-7yoilsho	4263	9	group	group	NN
cord-006229-7yoilsho	4263	10	displayed	display	VBD
cord-006229-7yoilsho	4263	11	a	a	DT
cord-006229-7yoilsho	4263	12	significantly	significantly	RB
cord-006229-7yoilsho	4263	13	impaired	impair	VBN
cord-006229-7yoilsho	4263	14	general	general	JJ
cord-006229-7yoilsho	4263	15	condition	condition	NN
cord-006229-7yoilsho	4263	16	,	,	,
cord-006229-7yoilsho	4263	17	a	a	DT
cord-006229-7yoilsho	4263	18	reduced	reduce	VBN
cord-006229-7yoilsho	4263	19	body	body	NN
cord-006229-7yoilsho	4263	20	temperature	temperature	NN
cord-006229-7yoilsho	4263	21	and	and	CC
cord-006229-7yoilsho	4263	22	a	a	DT
cord-006229-7yoilsho	4263	23	decreased	decrease	VBN
cord-006229-7yoilsho	4263	24	body	body	NN
cord-006229-7yoilsho	4263	25	weight	weight	NN
cord-006229-7yoilsho	4263	26	in	in	IN
cord-006229-7yoilsho	4263	27	comparison	comparison	NN
cord-006229-7yoilsho	4263	28	to	to	IN
cord-006229-7yoilsho	4263	29	the	the	DT
cord-006229-7yoilsho	4263	30	control	control	NN
cord-006229-7yoilsho	4263	31	and	and	CC
cord-006229-7yoilsho	4263	32	to	to	IN
cord-006229-7yoilsho	4263	33	the	the	DT
cord-006229-7yoilsho	4263	34	LPS	lp	NNS
cord-006229-7yoilsho	4263	35	treated	treat	VBD
cord-006229-7yoilsho	4263	36	animals	animal	NNS
cord-006229-7yoilsho	4263	37	,	,	,
cord-006229-7yoilsho	4263	38	respectively	respectively	RB
cord-006229-7yoilsho	4263	39	.	.	.
cord-006229-7yoilsho	4264	1	TNF	TNF	NNP
cord-006229-7yoilsho	4264	2	alpha	alpha	NN
cord-006229-7yoilsho	4264	3	levels	level	NNS
cord-006229-7yoilsho	4264	4	were	be	VBD
cord-006229-7yoilsho	4264	5	significantly	significantly	RB
cord-006229-7yoilsho	4264	6	increased	increase	VBN
cord-006229-7yoilsho	4264	7	by	by	IN
cord-006229-7yoilsho	4264	8	more	more	JJR
cord-006229-7yoilsho	4264	9	than	than	IN
cord-006229-7yoilsho	4264	10	200	200	CD
cord-006229-7yoilsho	4264	11	%	%	NN
cord-006229-7yoilsho	4264	12	or	or	CC
cord-006229-7yoilsho	4264	13	35	35	CD
cord-006229-7yoilsho	4264	14	%	%	NN
cord-006229-7yoilsho	4264	15	when	when	WRB
cord-006229-7yoilsho	4264	16	compared	compare	VBN
cord-006229-7yoilsho	4264	17	to	to	IN
cord-006229-7yoilsho	4264	18	the	the	DT
cord-006229-7yoilsho	4264	19	control	control	NN
cord-006229-7yoilsho	4264	20	or	or	CC
cord-006229-7yoilsho	4264	21	to	to	IN
cord-006229-7yoilsho	4264	22	the	the	DT
cord-006229-7yoilsho	4264	23	LPS	LPS	NNP
cord-006229-7yoilsho	4264	24	group	group	NN
cord-006229-7yoilsho	4264	25	,	,	,
cord-006229-7yoilsho	4264	26	respectively	respectively	RB
cord-006229-7yoilsho	4264	27	,	,	,
cord-006229-7yoilsho	4264	28	whereas	whereas	IN
cord-006229-7yoilsho	4264	29	IFN	IFN	NNP
cord-006229-7yoilsho	4264	30	gamma	gamma	NN
cord-006229-7yoilsho	4264	31	levels	level	NNS
cord-006229-7yoilsho	4264	32	were	be	VBD
cord-006229-7yoilsho	4264	33	elevated	elevate	VBN
cord-006229-7yoilsho	4264	34	by	by	IN
cord-006229-7yoilsho	4264	35	about	about	RB
cord-006229-7yoilsho	4264	36	11	11	CD
cord-006229-7yoilsho	4264	37	%	%	NN
cord-006229-7yoilsho	4264	38	in	in	IN
cord-006229-7yoilsho	4264	39	comparison	comparison	NN
cord-006229-7yoilsho	4264	40	to	to	IN
cord-006229-7yoilsho	4264	41	mice	mouse	NNS
cord-006229-7yoilsho	4264	42	which	which	WDT
cord-006229-7yoilsho	4264	43	had	have	VBD
cord-006229-7yoilsho	4264	44	received	receive	VBN
cord-006229-7yoilsho	4264	45	LPS	LPS	NNP
cord-006229-7yoilsho	4264	46	only	only	RB
cord-006229-7yoilsho	4264	47	.	.	.
cord-006229-7yoilsho	4265	1	In	in	IN
cord-006229-7yoilsho	4265	2	all	all	DT
cord-006229-7yoilsho	4265	3	investigated	investigate	VBN
cord-006229-7yoilsho	4265	4	organs	organ	NNS
cord-006229-7yoilsho	4265	5	,	,	,
cord-006229-7yoilsho	4265	6	but	but	CC
cord-006229-7yoilsho	4265	7	especially	especially	RB
cord-006229-7yoilsho	4265	8	in	in	IN
cord-006229-7yoilsho	4265	9	the	the	DT
cord-006229-7yoilsho	4265	10	liver	liver	NN
cord-006229-7yoilsho	4265	11	and	and	CC
cord-006229-7yoilsho	4265	12	in	in	IN
cord-006229-7yoilsho	4265	13	the	the	DT
cord-006229-7yoilsho	4265	14	kidney	kidney	NN
cord-006229-7yoilsho	4265	15	,	,	,
cord-006229-7yoilsho	4265	16	co	co	NN
cord-006229-7yoilsho	4265	17	-	-	NN
cord-006229-7yoilsho	4265	18	administration	administration	NN
cord-006229-7yoilsho	4265	19	of	of	IN
cord-006229-7yoilsho	4265	20	AMD3100	AMD3100	NNS
cord-006229-7yoilsho	4265	21	and	and	CC
cord-006229-7yoilsho	4265	22	LPS	LPS	NNP
cord-006229-7yoilsho	4265	23	caused	cause	VBD
cord-006229-7yoilsho	4265	24	massive	massive	JJ
cord-006229-7yoilsho	4265	25	oxidative	oxidative	JJ
cord-006229-7yoilsho	4265	26	stress	stress	NN
cord-006229-7yoilsho	4265	27	.	.	.
cord-006229-7yoilsho	4266	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	4266	2	,	,	,
cord-006229-7yoilsho	4266	3	the	the	DT
cord-006229-7yoilsho	4266	4	protein	protein	NN
cord-006229-7yoilsho	4266	5	contents	content	NNS
cord-006229-7yoilsho	4266	6	and	and	CC
cord-006229-7yoilsho	4266	7	the	the	DT
cord-006229-7yoilsho	4266	8	activities	activity	NNS
cord-006229-7yoilsho	4266	9	of	of	IN
cord-006229-7yoilsho	4266	10	several	several	JJ
cord-006229-7yoilsho	4266	11	CYP	CYP	NNP
cord-006229-7yoilsho	4266	12	enzymes	enzyme	NNS
cord-006229-7yoilsho	4266	13	in	in	IN
cord-006229-7yoilsho	4266	14	the	the	DT
cord-006229-7yoilsho	4266	15	liver	liver	NN
cord-006229-7yoilsho	4266	16	were	be	VBD
cord-006229-7yoilsho	4266	17	significantly	significantly	RB
cord-006229-7yoilsho	4266	18	reduced	reduce	VBN
cord-006229-7yoilsho	4266	19	.	.	.
cord-006229-7yoilsho	4267	1	Immunohistochemistry	Immunohistochemistry	NNP
cord-006229-7yoilsho	4267	2	revealed	reveal	VBD
cord-006229-7yoilsho	4267	3	gp91	gp91	NN
cord-006229-7yoilsho	4267	4	phox	phox	NNP
cord-006229-7yoilsho	4267	5	to	to	TO
cord-006229-7yoilsho	4267	6	occur	occur	VB
cord-006229-7yoilsho	4267	7	above	above	IN
cord-006229-7yoilsho	4267	8	average	average	JJ
cord-006229-7yoilsho	4267	9	,	,	,
cord-006229-7yoilsho	4267	10	whereas	whereas	IN
cord-006229-7yoilsho	4267	11	heme	heme	NN
cord-006229-7yoilsho	4267	12	oxygenase	oxygenase	NN
cord-006229-7yoilsho	4267	13	1	1	CD
cord-006229-7yoilsho	4267	14	expression	expression	NN
cord-006229-7yoilsho	4267	15	was	be	VBD
cord-006229-7yoilsho	4267	16	distinctly	distinctly	RB
cord-006229-7yoilsho	4267	17	decreased	decrease	VBN
cord-006229-7yoilsho	4267	18	.	.	.
cord-006229-7yoilsho	4268	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	4268	2	results	result	NNS
cord-006229-7yoilsho	4268	3	indicate	indicate	VBP
cord-006229-7yoilsho	4268	4	that	that	IN
cord-006229-7yoilsho	4268	5	a	a	DT
cord-006229-7yoilsho	4268	6	blockade	blockade	NN
cord-006229-7yoilsho	4268	7	of	of	IN
cord-006229-7yoilsho	4268	8	the	the	DT
cord-006229-7yoilsho	4268	9	CXCR4	CXCR4	NNS
cord-006229-7yoilsho	4268	10	in	in	IN
cord-006229-7yoilsho	4268	11	endotoxemia	endotoxemia	NN
cord-006229-7yoilsho	4268	12	is	be	VBZ
cord-006229-7yoilsho	4268	13	disadvantageous	disadvantageous	JJ
cord-006229-7yoilsho	4268	14	and	and	CC
cord-006229-7yoilsho	4268	15	even	even	RB
cord-006229-7yoilsho	4268	16	worsens	worsen	VBZ
cord-006229-7yoilsho	4268	17	the	the	DT
cord-006229-7yoilsho	4268	18	disease	disease	NN
cord-006229-7yoilsho	4268	19	.	.	.
cord-006229-7yoilsho	4269	1	Co	co	NN
cord-006229-7yoilsho	4269	2	-	-	NN
cord-006229-7yoilsho	4269	3	administration	administration	NN
cord-006229-7yoilsho	4269	4	of	of	IN
cord-006229-7yoilsho	4269	5	AMD3100	AMD3100	NNS
cord-006229-7yoilsho	4269	6	and	and	CC
cord-006229-7yoilsho	4269	7	LPS	LPS	NNP
cord-006229-7yoilsho	4269	8	impaired	impair	VBD
cord-006229-7yoilsho	4269	9	the	the	DT
cord-006229-7yoilsho	4269	10	health	health	NN
cord-006229-7yoilsho	4269	11	status	status	NN
cord-006229-7yoilsho	4269	12	of	of	IN
cord-006229-7yoilsho	4269	13	the	the	DT
cord-006229-7yoilsho	4269	14	animals	animal	NNS
cord-006229-7yoilsho	4269	15	,	,	,
cord-006229-7yoilsho	4269	16	caused	cause	VBD
cord-006229-7yoilsho	4269	17	massive	massive	JJ
cord-006229-7yoilsho	4269	18	oxidative	oxidative	JJ
cord-006229-7yoilsho	4269	19	stress	stress	NN
cord-006229-7yoilsho	4269	20	and	and	CC
cord-006229-7yoilsho	4269	21	diminished	diminish	VBD
cord-006229-7yoilsho	4269	22	the	the	DT
cord-006229-7yoilsho	4269	23	biotransformation	biotransformation	NN
cord-006229-7yoilsho	4269	24	capacity	capacity	NN
cord-006229-7yoilsho	4269	25	.	.	.
cord-006229-7yoilsho	4270	1	Thus	thus	RB
cord-006229-7yoilsho	4270	2	,	,	,
cord-006229-7yoilsho	4270	3	handling	handle	VBG
cord-006229-7yoilsho	4270	4	acute	acute	JJ
cord-006229-7yoilsho	4270	5	systemic	systemic	JJ
cord-006229-7yoilsho	4270	6	inflammation	inflammation	NN
cord-006229-7yoilsho	4270	7	with	with	IN
cord-006229-7yoilsho	4270	8	a	a	DT
cord-006229-7yoilsho	4270	9	CXCR4	cxcr4	NN
cord-006229-7yoilsho	4270	10	antagonist	antagonist	NN
cord-006229-7yoilsho	4270	11	can	can	MD
cord-006229-7yoilsho	4270	12	not	not	RB
cord-006229-7yoilsho	4270	13	be	be	VB
cord-006229-7yoilsho	4270	14	recommended	recommend	VBN
cord-006229-7yoilsho	4270	15	,	,	,
cord-006229-7yoilsho	4270	16	hence	hence	RB
cord-006229-7yoilsho	4270	17	indicating	indicate	VBG
cord-006229-7yoilsho	4270	18	the	the	DT
cord-006229-7yoilsho	4270	19	activation	activation	NN
cord-006229-7yoilsho	4270	20	of	of	IN
cord-006229-7yoilsho	4270	21	CXCR4	CXCR4	NNS
cord-006229-7yoilsho	4270	22	to	to	TO
cord-006229-7yoilsho	4270	23	be	be	VB
cord-006229-7yoilsho	4270	24	an	an	DT
cord-006229-7yoilsho	4270	25	attractive	attractive	JJ
cord-006229-7yoilsho	4270	26	treatment	treatment	NN
cord-006229-7yoilsho	4270	27	option	option	NN
cord-006229-7yoilsho	4270	28	.	.	.
cord-006229-7yoilsho	4271	1	Toll	toll	NN
cord-006229-7yoilsho	4271	2	-	-	HYPH
cord-006229-7yoilsho	4271	3	like	like	JJ
cord-006229-7yoilsho	4271	4	receptors	receptor	NNS
cord-006229-7yoilsho	4271	5	(	(	-LRB-
cord-006229-7yoilsho	4271	6	TLRs)recognizemicrobial	tlrs)recognizemicrobial	JJ
cord-006229-7yoilsho	4271	7	pathogens	pathogen	NNS
cord-006229-7yoilsho	4271	8	and	and	CC
cord-006229-7yoilsho	4271	9	trigger	trigger	VB
cord-006229-7yoilsho	4271	10	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	4271	11	immune	immune	JJ
cord-006229-7yoilsho	4271	12	responses	response	NNS
cord-006229-7yoilsho	4271	13	to	to	TO
cord-006229-7yoilsho	4271	14	control	control	VB
cord-006229-7yoilsho	4271	15	infections	infection	NNS
cord-006229-7yoilsho	4271	16	.	.	.
cord-006229-7yoilsho	4272	1	In	in	IN
cord-006229-7yoilsho	4272	2	acne	acne	NN
cord-006229-7yoilsho	4272	3	vulgaris	vulgaris	NN
cord-006229-7yoilsho	4272	4	,	,	,
cord-006229-7yoilsho	4272	5	activation	activation	NN
cord-006229-7yoilsho	4272	6	of	of	IN
cord-006229-7yoilsho	4272	7	TLR2	TLR2	NNP
cord-006229-7yoilsho	4272	8	by	by	IN
cord-006229-7yoilsho	4272	9	Propionibacterium	Propionibacterium	NNP
cord-006229-7yoilsho	4272	10	acnes	acnes	NN
cord-006229-7yoilsho	4272	11	contributes	contribute	VBZ
cord-006229-7yoilsho	4272	12	to	to	IN
cord-006229-7yoilsho	4272	13	inflammation	inflammation	NN
cord-006229-7yoilsho	4272	14	.	.	.
cord-006229-7yoilsho	4273	1	Although	although	IN
cord-006229-7yoilsho	4273	2	glucocorticoids	glucocorticoid	NNS
cord-006229-7yoilsho	4273	3	have	have	VBP
cord-006229-7yoilsho	4273	4	immunosuppressive	immunosuppressive	JJ
cord-006229-7yoilsho	4273	5	and	and	CC
cord-006229-7yoilsho	4273	6	anti	anti	JJ
cord-006229-7yoilsho	4273	7	-	-	JJ
cord-006229-7yoilsho	4273	8	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	4273	9	effects	effect	NNS
cord-006229-7yoilsho	4273	10	,	,	,
cord-006229-7yoilsho	4273	11	acne	acne	NN
cord-006229-7yoilsho	4273	12	can	can	MD
cord-006229-7yoilsho	4273	13	be	be	VB
cord-006229-7yoilsho	4273	14	provoked	provoke	VBN
cord-006229-7yoilsho	4273	15	by	by	IN
cord-006229-7yoilsho	4273	16	systemic	systemic	JJ
cord-006229-7yoilsho	4273	17	or	or	CC
cord-006229-7yoilsho	4273	18	topical	topical	JJ
cord-006229-7yoilsho	4273	19	treatment	treatment	NN
cord-006229-7yoilsho	4273	20	.	.	.
cord-006229-7yoilsho	4274	1	Enhanced	enhance	VBN
cord-006229-7yoilsho	4274	2	TLR2	TLR2	NNP
cord-006229-7yoilsho	4274	3	expression	expression	NN
cord-006229-7yoilsho	4274	4	by	by	IN
cord-006229-7yoilsho	4274	5	glucocorticoids	glucocorticoid	NNS
cord-006229-7yoilsho	4274	6	has	have	VBZ
cord-006229-7yoilsho	4274	7	been	be	VBN
cord-006229-7yoilsho	4274	8	reported	report	VBN
cord-006229-7yoilsho	4274	9	in	in	IN
cord-006229-7yoilsho	4274	10	undifferentiated	undifferentiated	JJ
cord-006229-7yoilsho	4274	11	keratinocytes	keratinocyte	NNS
cord-006229-7yoilsho	4274	12	,	,	,
cord-006229-7yoilsho	4274	13	however	however	RB
cord-006229-7yoilsho	4274	14	,	,	,
cord-006229-7yoilsho	4274	15	human	human	JJ
cord-006229-7yoilsho	4274	16	skin	skin	NN
cord-006229-7yoilsho	4274	17	cells	cell	NNS
cord-006229-7yoilsho	4274	18	of	of	IN
cord-006229-7yoilsho	4274	19	different	different	JJ
cord-006229-7yoilsho	4274	20	epidermal	epidermal	JJ
cord-006229-7yoilsho	4274	21	and	and	CC
cord-006229-7yoilsho	4274	22	dermal	dermal	JJ
cord-006229-7yoilsho	4274	23	layers	layer	NNS
cord-006229-7yoilsho	4274	24	have	have	VBP
cord-006229-7yoilsho	4274	25	not	not	RB
cord-006229-7yoilsho	4274	26	been	be	VBN
cord-006229-7yoilsho	4274	27	investigated	investigate	VBN
cord-006229-7yoilsho	4274	28	.	.	.
cord-006229-7yoilsho	4275	1	In	in	IN
cord-006229-7yoilsho	4275	2	this	this	DT
cord-006229-7yoilsho	4275	3	study	study	NN
cord-006229-7yoilsho	4275	4	,	,	,
cord-006229-7yoilsho	4275	5	the	the	DT
cord-006229-7yoilsho	4275	6	modulation	modulation	NN
cord-006229-7yoilsho	4275	7	of	of	IN
cord-006229-7yoilsho	4275	8	TLR	TLR	NNP
cord-006229-7yoilsho	4275	9	expression	expression	NN
cord-006229-7yoilsho	4275	10	by	by	IN
cord-006229-7yoilsho	4275	11	dexamethasone	dexamethasone	NN
cord-006229-7yoilsho	4275	12	was	be	VBD
cord-006229-7yoilsho	4275	13	assessed	assess	VBN
cord-006229-7yoilsho	4275	14	in	in	IN
cord-006229-7yoilsho	4275	15	monolayer	monolayer	NN
cord-006229-7yoilsho	4275	16	cultures	culture	NNS
cord-006229-7yoilsho	4275	17	of	of	IN
cord-006229-7yoilsho	4275	18	primary	primary	JJ
cord-006229-7yoilsho	4275	19	human	human	JJ
cord-006229-7yoilsho	4275	20	keratinocytes	keratinocyte	NNS
cord-006229-7yoilsho	4275	21	and	and	CC
cord-006229-7yoilsho	4275	22	dermal	dermal	JJ
cord-006229-7yoilsho	4275	23	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	4275	24	,	,	,
cord-006229-7yoilsho	4275	25	as	as	RB
cord-006229-7yoilsho	4275	26	well	well	RB
cord-006229-7yoilsho	4275	27	as	as	IN
cord-006229-7yoilsho	4275	28	the	the	DT
cord-006229-7yoilsho	4275	29	immortalized	immortalize	VBN
cord-006229-7yoilsho	4275	30	keratinocyte	keratinocyte	NNP
cord-006229-7yoilsho	4275	31	cell	cell	NN
cord-006229-7yoilsho	4275	32	line	line	NN
cord-006229-7yoilsho	4275	33	HaCaT.	hacat.	JJ
cord-006229-7yoilsho	4275	34	Constitutive	Constitutive	NNP
cord-006229-7yoilsho	4275	35	TLR2	TLR2	NNP
cord-006229-7yoilsho	4275	36	,	,	,
cord-006229-7yoilsho	4275	37	TLR1	TLR1	NNP
cord-006229-7yoilsho	4275	38	and	and	CC
cord-006229-7yoilsho	4275	39	TLR6	TLR6	NNP
cord-006229-7yoilsho	4275	40	mRNA	mRNA	NNP
cord-006229-7yoilsho	4275	41	and	and	CC
cord-006229-7yoilsho	4275	42	protein	protein	NN
cord-006229-7yoilsho	4275	43	expression	expression	NN
cord-006229-7yoilsho	4275	44	was	be	VBD
cord-006229-7yoilsho	4275	45	confirmed	confirm	VBN
cord-006229-7yoilsho	4275	46	in	in	IN
cord-006229-7yoilsho	4275	47	basal	basal	NN
cord-006229-7yoilsho	4275	48	keratinocytes	keratinocyte	NNS
cord-006229-7yoilsho	4275	49	,	,	,
cord-006229-7yoilsho	4275	50	calcium	calcium	NN
cord-006229-7yoilsho	4275	51	-	-	HYPH
cord-006229-7yoilsho	4275	52	induced	induce	VBN
cord-006229-7yoilsho	4275	53	differentiated	differentiate	VBN
cord-006229-7yoilsho	4275	54	keratinocytes	keratinocyte	NNS
cord-006229-7yoilsho	4275	55	,	,	,
cord-006229-7yoilsho	4275	56	HaCaT	HaCaT	NNP
cord-006229-7yoilsho	4275	57	cells	cell	NNS
cord-006229-7yoilsho	4275	58	and	and	CC
cord-006229-7yoilsho	4275	59	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	4275	60	by	by	IN
cord-006229-7yoilsho	4275	61	qPCR	qPCR	NNP
cord-006229-7yoilsho	4275	62	and	and	CC
cord-006229-7yoilsho	4275	63	western	western	JJ
cord-006229-7yoilsho	4275	64	blotting	blotting	NN
cord-006229-7yoilsho	4275	65	.	.	.
cord-006229-7yoilsho	4276	1	Dexamethasone	Dexamethasone	NNP
cord-006229-7yoilsho	4276	2	induced	induce	VBD
cord-006229-7yoilsho	4276	3	TLR2	TLR2	NNP
cord-006229-7yoilsho	4276	4	expression	expression	NN
cord-006229-7yoilsho	4276	5	in	in	IN
cord-006229-7yoilsho	4276	6	a	a	DT
cord-006229-7yoilsho	4276	7	time	time	NN
cord-006229-7yoilsho	4276	8	-	-	HYPH
cord-006229-7yoilsho	4276	9	dependent	dependent	JJ
cord-006229-7yoilsho	4276	10	and	and	CC
cord-006229-7yoilsho	4276	11	concentration	concentration	NN
cord-006229-7yoilsho	4276	12	-	-	HYPH
cord-006229-7yoilsho	4276	13	dependent	dependent	JJ
cord-006229-7yoilsho	4276	14	manner	manner	NN
cord-006229-7yoilsho	4276	15	and	and	CC
cord-006229-7yoilsho	4276	16	reduced	reduced	JJ
cord-006229-7yoilsho	4276	17	TLR1/6	tlr1/6	CD
cord-006229-7yoilsho	4276	18	expression	expression	NN
cord-006229-7yoilsho	4276	19	in	in	IN
cord-006229-7yoilsho	4276	20	keratinocytes	keratinocyte	NNS
cord-006229-7yoilsho	4276	21	but	but	CC
cord-006229-7yoilsho	4276	22	not	not	RB
cord-006229-7yoilsho	4276	23	in	in	IN
cord-006229-7yoilsho	4276	24	HaCaT	HaCaT	NNP
cord-006229-7yoilsho	4276	25	cells	cell	NNS
cord-006229-7yoilsho	4276	26	or	or	CC
cord-006229-7yoilsho	4276	27	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	4276	28	.	.	.
cord-006229-7yoilsho	4277	1	Stimulation	stimulation	NN
cord-006229-7yoilsho	4277	2	with	with	IN
cord-006229-7yoilsho	4277	3	dexamethasone	dexamethasone	NN
cord-006229-7yoilsho	4277	4	in	in	IN
cord-006229-7yoilsho	4277	5	the	the	DT
cord-006229-7yoilsho	4277	6	presence	presence	NN
cord-006229-7yoilsho	4277	7	of	of	IN
cord-006229-7yoilsho	4277	8	the	the	DT
cord-006229-7yoilsho	4277	9	pro	pro	JJ
cord-006229-7yoilsho	4277	10	-	-	JJ
cord-006229-7yoilsho	4277	11	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	4277	12	cytokines	cytokine	NNS
cord-006229-7yoilsho	4277	13	TNFα	TNFα	NNS
cord-006229-7yoilsho	4277	14	or	or	CC
cord-006229-7yoilsho	4277	15	IL-1β	il-1β	CC
cord-006229-7yoilsho	4277	16	further	further	RB
cord-006229-7yoilsho	4277	17	increased	increase	VBD
cord-006229-7yoilsho	4277	18	TLR2	TLR2	NNP
cord-006229-7yoilsho	4277	19	mRNA	mRNA	NNP
cord-006229-7yoilsho	4277	20	levels	level	NNS
cord-006229-7yoilsho	4277	21	.	.	.
cord-006229-7yoilsho	4278	1	Gene	gene	NN
cord-006229-7yoilsho	4278	2	expression	expression	NN
cord-006229-7yoilsho	4278	3	of	of	IN
cord-006229-7yoilsho	4278	4	MAPK	MAPK	NNP
cord-006229-7yoilsho	4278	5	phosphatase-1	phosphatase-1	NNP
cord-006229-7yoilsho	4278	6	(	(	-LRB-
cord-006229-7yoilsho	4278	7	MKP-1	MKP-1	NNP
cord-006229-7yoilsho	4278	8	)	)	-RRB-
cord-006229-7yoilsho	4278	9	was	be	VBD
cord-006229-7yoilsho	4278	10	also	also	RB
cord-006229-7yoilsho	4278	11	upregulated	upregulate	VBN
cord-006229-7yoilsho	4278	12	by	by	IN
cord-006229-7yoilsho	4278	13	dexamethasone	dexamethasone	NN
cord-006229-7yoilsho	4278	14	.	.	.
cord-006229-7yoilsho	4279	1	Glucocorticoid	Glucocorticoid	NNP
cord-006229-7yoilsho	4279	2	-	-	HYPH
cord-006229-7yoilsho	4279	3	induced	induce	VBN
cord-006229-7yoilsho	4279	4	TLR2	TLR2	NNP
cord-006229-7yoilsho	4279	5	expression	expression	NN
cord-006229-7yoilsho	4279	6	was	be	VBD
cord-006229-7yoilsho	4279	7	negatively	negatively	RB
cord-006229-7yoilsho	4279	8	regulated	regulate	VBN
cord-006229-7yoilsho	4279	9	by	by	IN
cord-006229-7yoilsho	4279	10	p38	p38	CD
cord-006229-7yoilsho	4279	11	MAPK	MAPK	NNP
cord-006229-7yoilsho	4279	12	signalling	signal	VBG
cord-006229-7yoilsho	4279	13	under	under	IN
cord-006229-7yoilsho	4279	14	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	4279	15	conditions	condition	NNS
cord-006229-7yoilsho	4279	16	through	through	IN
cord-006229-7yoilsho	4279	17	MKP-1	MKP-1	NNP
cord-006229-7yoilsho	4279	18	induction	induction	NN
cord-006229-7yoilsho	4279	19	which	which	WDT
cord-006229-7yoilsho	4279	20	functions	function	VBZ
cord-006229-7yoilsho	4279	21	to	to	TO
cord-006229-7yoilsho	4279	22	deactivate	deactivate	VB
cord-006229-7yoilsho	4279	23	MAPKs	mapk	NNS
cord-006229-7yoilsho	4279	24	.	.	.
cord-006229-7yoilsho	4280	1	As	as	IN
cord-006229-7yoilsho	4280	2	expected	expect	VBN
cord-006229-7yoilsho	4280	3	,	,	,
cord-006229-7yoilsho	4280	4	dexamethasone	dexamethasone	NN
cord-006229-7yoilsho	4280	5	inhibited	inhibit	VBD
cord-006229-7yoilsho	4280	6	the	the	DT
cord-006229-7yoilsho	4280	7	immune	immune	JJ
cord-006229-7yoilsho	4280	8	responses	response	NNS
cord-006229-7yoilsho	4280	9	linked	link	VBN
cord-006229-7yoilsho	4280	10	to	to	IN
cord-006229-7yoilsho	4280	11	TLR2	TLR2	NNP
cord-006229-7yoilsho	4280	12	signalling	signalling	NN
cord-006229-7yoilsho	4280	13	as	as	IN
cord-006229-7yoilsho	4280	14	demonstrated	demonstrate	VBN
cord-006229-7yoilsho	4280	15	by	by	IN
cord-006229-7yoilsho	4280	16	reduced	reduce	VBN
cord-006229-7yoilsho	4280	17	IL-8	il-8	NN
cord-006229-7yoilsho	4280	18	,	,	,
cord-006229-7yoilsho	4280	19	IL-1β	IL-1β	NNP
cord-006229-7yoilsho	4280	20	,	,	,
cord-006229-7yoilsho	4280	21	MMP-1	MMP-1	NNP
cord-006229-7yoilsho	4280	22	and	and	CC
cord-006229-7yoilsho	4280	23	MCP-1	MCP-1	NNP
cord-006229-7yoilsho	4280	24	levels	level	NNS
cord-006229-7yoilsho	4280	25	.	.	.
cord-006229-7yoilsho	4281	1	However	however	RB
cord-006229-7yoilsho	4281	2	,	,	,
cord-006229-7yoilsho	4281	3	the	the	DT
cord-006229-7yoilsho	4281	4	expression	expression	NN
cord-006229-7yoilsho	4281	5	of	of	IN
cord-006229-7yoilsho	4281	6	TRAF6	TRAF6	NNP
cord-006229-7yoilsho	4281	7	,	,	,
cord-006229-7yoilsho	4281	8	a	a	DT
cord-006229-7yoilsho	4281	9	critical	critical	JJ
cord-006229-7yoilsho	4281	10	cytosolic	cytosolic	JJ
cord-006229-7yoilsho	4281	11	regulator	regulator	NN
cord-006229-7yoilsho	4281	12	of	of	IN
cord-006229-7yoilsho	4281	13	TLR	TLR	NNP
cord-006229-7yoilsho	4281	14	-	-	:
cord-006229-7yoilsho	4281	15	and	and	CC
cord-006229-7yoilsho	4281	16	TNF	TNF	NNP
cord-006229-7yoilsho	4281	17	family	family	NN
cord-006229-7yoilsho	4281	18	-	-	HYPH
cord-006229-7yoilsho	4281	19	mediated	mediate	VBN
cord-006229-7yoilsho	4281	20	signalling	signalling	NN
cord-006229-7yoilsho	4281	21	,	,	,
cord-006229-7yoilsho	4281	22	was	be	VBD
cord-006229-7yoilsho	4281	23	further	further	RB
cord-006229-7yoilsho	4281	24	upregulated	upregulate	VBN
cord-006229-7yoilsho	4281	25	by	by	IN
cord-006229-7yoilsho	4281	26	the	the	DT
cord-006229-7yoilsho	4281	27	TLR2	TLR2	NNP
cord-006229-7yoilsho	4281	28	agonist	agonist	NN
cord-006229-7yoilsho	4281	29	HKLM	HKLM	NNP
cord-006229-7yoilsho	4281	30	(	(	-LRB-
cord-006229-7yoilsho	4281	31	heat	heat	NN
cord-006229-7yoilsho	4281	32	-	-	HYPH
cord-006229-7yoilsho	4281	33	killed	kill	VBN
cord-006229-7yoilsho	4281	34	Lysteria	Lysteria	NNP
cord-006229-7yoilsho	4281	35	monocytogenes	monocytogenes	NNP
cord-006229-7yoilsho	4281	36	)	)	-RRB-
cord-006229-7yoilsho	4281	37	in	in	IN
cord-006229-7yoilsho	4281	38	dexamethasonepretreated	dexamethasonepretreate	VBN
cord-006229-7yoilsho	4281	39	basal	basal	NN
cord-006229-7yoilsho	4281	40	keratinocytes	keratinocyte	NNS
cord-006229-7yoilsho	4281	41	.	.	.
cord-006229-7yoilsho	4282	1	Conclusively	conclusively	RB
cord-006229-7yoilsho	4282	2	,	,	,
cord-006229-7yoilsho	4282	3	our	-PRON-	PRP$
cord-006229-7yoilsho	4282	4	results	result	NNS
cord-006229-7yoilsho	4282	5	provide	provide	VBP
cord-006229-7yoilsho	4282	6	novel	novel	JJ
cord-006229-7yoilsho	4282	7	insights	insight	NNS
cord-006229-7yoilsho	4282	8	intothe	intothe	NNP
cord-006229-7yoilsho	4282	9	molecular	molecular	JJ
cord-006229-7yoilsho	4282	10	mechanismsof	mechanismsof	NNP
cord-006229-7yoilsho	4282	11	glucocorticoid	glucocorticoid	NN
cord-006229-7yoilsho	4282	12	-	-	HYPH
cord-006229-7yoilsho	4282	13	mediatedTLR	mediatedTLR	VBN
cord-006229-7yoilsho	4282	14	expressionand	expressionand	NN
cord-006229-7yoilsho	4282	15	function	function	NN
cord-006229-7yoilsho	4282	16	in	in	IN
cord-006229-7yoilsho	4282	17	human	human	JJ
cord-006229-7yoilsho	4282	18	skin	skin	NN
cord-006229-7yoilsho	4282	19	cells	cell	NNS
cord-006229-7yoilsho	4282	20	.	.	.
cord-006229-7yoilsho	4283	1	Psoriasis	psoriasis	NN
cord-006229-7yoilsho	4283	2	is	be	VBZ
cord-006229-7yoilsho	4283	3	a	a	DT
cord-006229-7yoilsho	4283	4	cutaneous	cutaneous	JJ
cord-006229-7yoilsho	4283	5	chronic	chronic	JJ
cord-006229-7yoilsho	4283	6	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	4283	7	disease	disease	NN
cord-006229-7yoilsho	4283	8	characterized	characterize	VBN
cord-006229-7yoilsho	4283	9	by	by	IN
cord-006229-7yoilsho	4283	10	increased	increase	VBN
cord-006229-7yoilsho	4283	11	amounts	amount	NNS
cord-006229-7yoilsho	4283	12	of	of	IN
cord-006229-7yoilsho	4283	13	IL-1	IL-1	NNP
cord-006229-7yoilsho	4283	14	cytokines	cytokine	NNS
cord-006229-7yoilsho	4283	15	and	and	CC
cord-006229-7yoilsho	4283	16	T	T	NNP
cord-006229-7yoilsho	4283	17	helper	helper	NN
cord-006229-7yoilsho	4283	18	17	17	CD
cord-006229-7yoilsho	4283	19	(	(	-LRB-
cord-006229-7yoilsho	4283	20	Th17	Th17	NNP
cord-006229-7yoilsho	4283	21	)	)	-RRB-
cord-006229-7yoilsho	4283	22	related	relate	VBN
cord-006229-7yoilsho	4283	23	cytokines	cytokine	NNS
cord-006229-7yoilsho	4283	24	in	in	IN
cord-006229-7yoilsho	4283	25	lesional	lesional	JJ
cord-006229-7yoilsho	4283	26	psoriatic	psoriatic	JJ
cord-006229-7yoilsho	4283	27	skin	skin	NN
cord-006229-7yoilsho	4283	28	.	.	.
cord-006229-7yoilsho	4284	1	Treatment	treatment	NN
cord-006229-7yoilsho	4284	2	with	with	IN
cord-006229-7yoilsho	4284	3	beta	beta	JJ
cord-006229-7yoilsho	4284	4	-	-	HYPH
cord-006229-7yoilsho	4284	5	adrenoceptor	adrenoceptor	NN
cord-006229-7yoilsho	4284	6	antagonists	antagonist	NNS
cord-006229-7yoilsho	4284	7	is	be	VBZ
cord-006229-7yoilsho	4284	8	associated	associate	VBN
cord-006229-7yoilsho	4284	9	with	with	IN
cord-006229-7yoilsho	4284	10	induction	induction	NN
cord-006229-7yoilsho	4284	11	or	or	CC
cord-006229-7yoilsho	4284	12	aggravation	aggravation	NN
cord-006229-7yoilsho	4284	13	of	of	IN
cord-006229-7yoilsho	4284	14	psoriasis	psoriasis	NN
cord-006229-7yoilsho	4284	15	,	,	,
cord-006229-7yoilsho	4284	16	however	however	RB
cord-006229-7yoilsho	4284	17	,	,	,
cord-006229-7yoilsho	4284	18	the	the	DT
cord-006229-7yoilsho	4284	19	underlying	underlying	JJ
cord-006229-7yoilsho	4284	20	mechanism	mechanism	NN
cord-006229-7yoilsho	4284	21	is	be	VBZ
cord-006229-7yoilsho	4284	22	poorly	poorly	RB
cord-006229-7yoilsho	4284	23	understood	understand	VBN
cord-006229-7yoilsho	4284	24	.	.	.
cord-006229-7yoilsho	4285	1	Previously	previously	RB
cord-006229-7yoilsho	4285	2	,	,	,
cord-006229-7yoilsho	4285	3	we	-PRON-	PRP
cord-006229-7yoilsho	4285	4	could	could	MD
cord-006229-7yoilsho	4285	5	demonstrate	demonstrate	VB
cord-006229-7yoilsho	4285	6	a	a	DT
cord-006229-7yoilsho	4285	7	pivotal	pivotal	JJ
cord-006229-7yoilsho	4285	8	role	role	NN
cord-006229-7yoilsho	4285	9	for	for	IN
cord-006229-7yoilsho	4285	10	Langerhans	Langerhans	NNP
cord-006229-7yoilsho	4285	11	Cells	Cells	NNPS
cord-006229-7yoilsho	4285	12	and	and	CC
cord-006229-7yoilsho	4285	13	dermal	dermal	JJ
cord-006229-7yoilsho	4285	14	dendritic	dendritic	JJ
cord-006229-7yoilsho	4285	15	cells	cell	NNS
cord-006229-7yoilsho	4285	16	in	in	IN
cord-006229-7yoilsho	4285	17	antimalarial	antimalarial	JJ
cord-006229-7yoilsho	4285	18	-	-	HYPH
cord-006229-7yoilsho	4285	19	provoked	provoke	VBN
cord-006229-7yoilsho	4285	20	psoriasis	psoriasis	NN
cord-006229-7yoilsho	4285	21	by	by	IN
cord-006229-7yoilsho	4285	22	maintaining	maintain	VBG
cord-006229-7yoilsho	4285	23	a	a	DT
cord-006229-7yoilsho	4285	24	potent	potent	JJ
cord-006229-7yoilsho	4285	25	Th17	th17	NN
cord-006229-7yoilsho	4285	26	activity	activity	NN
cord-006229-7yoilsho	4285	27	.	.	.
cord-006229-7yoilsho	4286	1	In	in	IN
cord-006229-7yoilsho	4286	2	the	the	DT
cord-006229-7yoilsho	4286	3	present	present	JJ
cord-006229-7yoilsho	4286	4	study	study	NN
cord-006229-7yoilsho	4286	5	,	,	,
cord-006229-7yoilsho	4286	6	we	-PRON-	PRP
cord-006229-7yoilsho	4286	7	investigated	investigate	VBD
cord-006229-7yoilsho	4286	8	the	the	DT
cord-006229-7yoilsho	4286	9	effect	effect	NN
cord-006229-7yoilsho	4286	10	of	of	IN
cord-006229-7yoilsho	4286	11	propranolol	propranolol	NN
cord-006229-7yoilsho	4286	12	on	on	IN
cord-006229-7yoilsho	4286	13	human	human	JJ
cord-006229-7yoilsho	4286	14	monocyte	monocyte	NNP
cord-006229-7yoilsho	4286	15	-	-	HYPH
cord-006229-7yoilsho	4286	16	derived	derive	VBN
cord-006229-7yoilsho	4286	17	Langerhans	Langerhans	NNP
cord-006229-7yoilsho	4286	18	-	-	HYPH
cord-006229-7yoilsho	4286	19	like	like	JJ
cord-006229-7yoilsho	4286	20	cells	cell	NNS
cord-006229-7yoilsho	4286	21	(	(	-LRB-
cord-006229-7yoilsho	4286	22	MoLC	MoLC	NNP
cord-006229-7yoilsho	4286	23	)	)	-RRB-
cord-006229-7yoilsho	4286	24	and	and	CC
cord-006229-7yoilsho	4286	25	dendritic	dendritic	JJ
cord-006229-7yoilsho	4286	26	cells	cell	NNS
cord-006229-7yoilsho	4286	27	(	(	-LRB-
cord-006229-7yoilsho	4286	28	MoDC	MoDC	NNP
cord-006229-7yoilsho	4286	29	)	)	-RRB-
cord-006229-7yoilsho	4286	30	under	under	IN
cord-006229-7yoilsho	4286	31	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	4286	32	conditions	condition	NNS
cord-006229-7yoilsho	4286	33	.	.	.
cord-006229-7yoilsho	4287	1	In	in	IN
cord-006229-7yoilsho	4287	2	the	the	DT
cord-006229-7yoilsho	4287	3	presence	presence	NN
cord-006229-7yoilsho	4287	4	of	of	IN
cord-006229-7yoilsho	4287	5	IL-1β	il-1β	NN
cord-006229-7yoilsho	4287	6	,	,	,
cord-006229-7yoilsho	4287	7	propranolol	propranolol	NN
cord-006229-7yoilsho	4287	8	induced	induce	VBD
cord-006229-7yoilsho	4287	9	the	the	DT
cord-006229-7yoilsho	4287	10	Th17	th17	NN
cord-006229-7yoilsho	4287	11	priming	prime	VBG
cord-006229-7yoilsho	4287	12	cytokines	cytokine	NNS
cord-006229-7yoilsho	4287	13	IL-23	IL-23	NNP
cord-006229-7yoilsho	4287	14	and	and	CC
cord-006229-7yoilsho	4287	15	IL-6	IL-6	NNP
cord-006229-7yoilsho	4287	16	in	in	IN
cord-006229-7yoilsho	4287	17	a	a	DT
cord-006229-7yoilsho	4287	18	concentration	concentration	NN
cord-006229-7yoilsho	4287	19	-	-	HYPH
cord-006229-7yoilsho	4287	20	dependent	dependent	JJ
cord-006229-7yoilsho	4287	21	manner	manner	NN
cord-006229-7yoilsho	4287	22	.	.	.
cord-006229-7yoilsho	4288	1	The	the	DT
cord-006229-7yoilsho	4288	2	increased	increase	VBN
cord-006229-7yoilsho	4288	3	cytokine	cytokine	NN
cord-006229-7yoilsho	4288	4	release	release	NN
cord-006229-7yoilsho	4288	5	was	be	VBD
cord-006229-7yoilsho	4288	6	not	not	RB
cord-006229-7yoilsho	4288	7	mediated	mediate	VBN
cord-006229-7yoilsho	4288	8	by	by	IN
cord-006229-7yoilsho	4288	9	cAMP	camp	NN
cord-006229-7yoilsho	4288	10	suggesting	suggest	VBG
cord-006229-7yoilsho	4288	11	GPCR	GPCR	NNP
cord-006229-7yoilsho	4288	12	-	-	HYPH
cord-006229-7yoilsho	4288	13	independent	independent	JJ
cord-006229-7yoilsho	4288	14	pathways	pathway	NNS
cord-006229-7yoilsho	4288	15	.	.	.
cord-006229-7yoilsho	4289	1	In	in	IN
cord-006229-7yoilsho	4289	2	contrast	contrast	NN
cord-006229-7yoilsho	4289	3	,	,	,
cord-006229-7yoilsho	4289	4	IL-36γ	il-36γ	NN
cord-006229-7yoilsho	4289	5	and	and	CC
cord-006229-7yoilsho	4289	6	LPS	LPS	NNP
cord-006229-7yoilsho	4289	7	failed	fail	VBD
cord-006229-7yoilsho	4289	8	to	to	TO
cord-006229-7yoilsho	4289	9	increase	increase	VB
cord-006229-7yoilsho	4289	10	IL-23	IL-23	NNP
cord-006229-7yoilsho	4289	11	release	release	NN
cord-006229-7yoilsho	4289	12	in	in	IN
cord-006229-7yoilsho	4289	13	MoLC	molc	NN
cord-006229-7yoilsho	4289	14	and	and	CC
cord-006229-7yoilsho	4289	15	MoDC	modc	VB
cord-006229-7yoilsho	4289	16	in	in	IN
cord-006229-7yoilsho	4289	17	the	the	DT
cord-006229-7yoilsho	4289	18	presence	presence	NN
cord-006229-7yoilsho	4289	19	of	of	IN
cord-006229-7yoilsho	4289	20	propranolol	propranolol	NN
cord-006229-7yoilsho	4289	21	but	but	CC
cord-006229-7yoilsho	4289	22	further	further	RB
cord-006229-7yoilsho	4289	23	induced	induce	VBN
cord-006229-7yoilsho	4289	24	secretion	secretion	NN
cord-006229-7yoilsho	4289	25	of	of	IN
cord-006229-7yoilsho	4289	26	IL-1β	il-1β	NN
cord-006229-7yoilsho	4289	27	.	.	.
cord-006229-7yoilsho	4290	1	Autophagy	Autophagy	NNP
cord-006229-7yoilsho	4290	2	has	have	VBZ
cord-006229-7yoilsho	4290	3	been	be	VBN
cord-006229-7yoilsho	4290	4	linked	link	VBN
cord-006229-7yoilsho	4290	5	with	with	IN
cord-006229-7yoilsho	4290	6	the	the	DT
cord-006229-7yoilsho	4290	7	secretion	secretion	NN
cord-006229-7yoilsho	4290	8	of	of	IN
cord-006229-7yoilsho	4290	9	IL-1	IL-1	NNP
cord-006229-7yoilsho	4290	10	family	family	NN
cord-006229-7yoilsho	4290	11	cytokines	cytokine	NNS
cord-006229-7yoilsho	4290	12	that	that	WDT
cord-006229-7yoilsho	4290	13	are	be	VBP
cord-006229-7yoilsho	4290	14	upregulated	upregulate	VBN
cord-006229-7yoilsho	4290	15	in	in	IN
cord-006229-7yoilsho	4290	16	chronic	chronic	JJ
cord-006229-7yoilsho	4290	17	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	4290	18	disorders	disorder	NNS
cord-006229-7yoilsho	4290	19	such	such	JJ
cord-006229-7yoilsho	4290	20	as	as	IN
cord-006229-7yoilsho	4290	21	psoriasis	psoriasis	NN
cord-006229-7yoilsho	4290	22	.	.	.
cord-006229-7yoilsho	4291	1	Propranolol	propranolol	NN
cord-006229-7yoilsho	4291	2	upregulated	upregulate	VBD
cord-006229-7yoilsho	4291	3	the	the	DT
cord-006229-7yoilsho	4291	4	expression	expression	NN
cord-006229-7yoilsho	4291	5	levels	level	NNS
cord-006229-7yoilsho	4291	6	of	of	IN
cord-006229-7yoilsho	4291	7	the	the	DT
cord-006229-7yoilsho	4291	8	autophagy	autophagy	NN
cord-006229-7yoilsho	4291	9	marker	marker	NN
cord-006229-7yoilsho	4291	10	p62	p62	NN
cord-006229-7yoilsho	4291	11	and	and	CC
cord-006229-7yoilsho	4291	12	LC3-I	LC3-I	NNP
cord-006229-7yoilsho	4291	13	to	to	TO
cord-006229-7yoilsho	4291	14	LC3-II	lc3-ii	NN
cord-006229-7yoilsho	4291	15	conversion	conversion	NN
cord-006229-7yoilsho	4291	16	,	,	,
cord-006229-7yoilsho	4291	17	induced	induce	VBN
cord-006229-7yoilsho	4291	18	accumulation	accumulation	NN
cord-006229-7yoilsho	4291	19	of	of	IN
cord-006229-7yoilsho	4291	20	LC3	lc3	JJ
cord-006229-7yoilsho	4291	21	positive	positive	JJ
cord-006229-7yoilsho	4291	22	vesicles	vesicle	NNS
cord-006229-7yoilsho	4291	23	,	,	,
cord-006229-7yoilsho	4291	24	as	as	RB
cord-006229-7yoilsho	4291	25	well	well	RB
cord-006229-7yoilsho	4291	26	as	as	IN
cord-006229-7yoilsho	4291	27	expression	expression	NN
cord-006229-7yoilsho	4291	28	of	of	IN
cord-006229-7yoilsho	4291	29	IL-1	IL-1	NNP
cord-006229-7yoilsho	4291	30	signalling	signal	VBG
cord-006229-7yoilsho	4291	31	downstream	downstream	JJ
cord-006229-7yoilsho	4291	32	adapter	adapter	NN
cord-006229-7yoilsho	4291	33	molecule	molecule	NN
cord-006229-7yoilsho	4291	34	TRAF6	TRAF6	NNP
cord-006229-7yoilsho	4291	35	,	,	,
cord-006229-7yoilsho	4291	36	indicating	indicate	VBG
cord-006229-7yoilsho	4291	37	a	a	DT
cord-006229-7yoilsho	4291	38	late	late	JJ
cord-006229-7yoilsho	4291	39	-	-	HYPH
cord-006229-7yoilsho	4291	40	stage	stage	NN
cord-006229-7yoilsho	4291	41	block	block	NN
cord-006229-7yoilsho	4291	42	in	in	IN
cord-006229-7yoilsho	4291	43	autophagy	autophagy	NN
cord-006229-7yoilsho	4291	44	.	.	.
cord-006229-7yoilsho	4292	1	In	in	IN
cord-006229-7yoilsho	4292	2	summary	summary	NN
cord-006229-7yoilsho	4292	3	,	,	,
cord-006229-7yoilsho	4292	4	our	-PRON-	PRP$
cord-006229-7yoilsho	4292	5	results	result	NNS
cord-006229-7yoilsho	4292	6	suggest	suggest	VBP
cord-006229-7yoilsho	4292	7	a	a	DT
cord-006229-7yoilsho	4292	8	prominent	prominent	JJ
cord-006229-7yoilsho	4292	9	role	role	NN
cord-006229-7yoilsho	4292	10	of	of	IN
cord-006229-7yoilsho	4292	11	cutaneous	cutaneous	JJ
cord-006229-7yoilsho	4292	12	dendritic	dendritic	JJ
cord-006229-7yoilsho	4292	13	cell	cell	NN
cord-006229-7yoilsho	4292	14	subtypes	subtype	NNS
cord-006229-7yoilsho	4292	15	in	in	IN
cord-006229-7yoilsho	4292	16	psoriasis	psoriasis	NN
cord-006229-7yoilsho	4292	17	-	-	HYPH
cord-006229-7yoilsho	4292	18	like	like	JJ
cord-006229-7yoilsho	4292	19	skin	skin	NN
cord-006229-7yoilsho	4292	20	inflammation	inflammation	NN
cord-006229-7yoilsho	4292	21	mediated	mediate	VBN
cord-006229-7yoilsho	4292	22	by	by	IN
cord-006229-7yoilsho	4292	23	propranolol	propranolol	NN
cord-006229-7yoilsho	4292	24	and	and	CC
cord-006229-7yoilsho	4292	25	possibly	possibly	RB
cord-006229-7yoilsho	4292	26	other	other	JJ
cord-006229-7yoilsho	4292	27	beta	beta	NN
cord-006229-7yoilsho	4292	28	blockers	blocker	NNS
cord-006229-7yoilsho	4292	29	.	.	.
cord-006229-7yoilsho	4293	1	Langerhans	Langerhans	NNP
cord-006229-7yoilsho	4293	2	cells	cell	NNS
cord-006229-7yoilsho	4293	3	(	(	-LRB-
cord-006229-7yoilsho	4293	4	LCs	LCs	NNP
cord-006229-7yoilsho	4293	5	)	)	-RRB-
cord-006229-7yoilsho	4293	6	represent	represent	VBP
cord-006229-7yoilsho	4293	7	a	a	DT
cord-006229-7yoilsho	4293	8	highly	highly	RB
cord-006229-7yoilsho	4293	9	specialized	specialized	JJ
cord-006229-7yoilsho	4293	10	subset	subset	NN
cord-006229-7yoilsho	4293	11	of	of	IN
cord-006229-7yoilsho	4293	12	epidermal	epidermal	JJ
cord-006229-7yoilsho	4293	13	dendritic	dendritic	JJ
cord-006229-7yoilsho	4293	14	cells	cell	NNS
cord-006229-7yoilsho	4293	15	(	(	-LRB-
cord-006229-7yoilsho	4293	16	DCs	DCs	NNP
cord-006229-7yoilsho	4293	17	)	)	-RRB-
cord-006229-7yoilsho	4293	18	,	,	,
cord-006229-7yoilsho	4293	19	yet	yet	CC
cord-006229-7yoilsho	4293	20	not	not	RB
cord-006229-7yoilsho	4293	21	fully	fully	RB
cord-006229-7yoilsho	4293	22	understood	understand	VBN
cord-006229-7yoilsho	4293	23	in	in	IN
cord-006229-7yoilsho	4293	24	their	-PRON-	PRP$
cord-006229-7yoilsho	4293	25	function	function	NN
cord-006229-7yoilsho	4293	26	of	of	IN
cord-006229-7yoilsho	4293	27	balancing	balance	VBG
cord-006229-7yoilsho	4293	28	skin	skin	NN
cord-006229-7yoilsho	4293	29	immunity	immunity	NN
cord-006229-7yoilsho	4293	30	.	.	.
cord-006229-7yoilsho	4294	1	In	in	IN
cord-006229-7yoilsho	4294	2	the	the	DT
cord-006229-7yoilsho	4294	3	present	present	JJ
cord-006229-7yoilsho	4294	4	study	study	NN
cord-006229-7yoilsho	4294	5	,	,	,
cord-006229-7yoilsho	4294	6	we	-PRON-	PRP
cord-006229-7yoilsho	4294	7	investigated	investigate	VBD
cord-006229-7yoilsho	4294	8	in	in	IN
cord-006229-7yoilsho	4294	9	vitro	vitro	FW
cord-006229-7yoilsho	4294	10	generated	generate	VBD
cord-006229-7yoilsho	4294	11	Langerhans	Langerhans	NNP
cord-006229-7yoilsho	4294	12	-	-	HYPH
cord-006229-7yoilsho	4294	13	like	like	JJ
cord-006229-7yoilsho	4294	14	cells	cell	NNS
cord-006229-7yoilsho	4294	15	obtained	obtain	VBN
cord-006229-7yoilsho	4294	16	from	from	IN
cord-006229-7yoilsho	4294	17	the	the	DT
cord-006229-7yoilsho	4294	18	human	human	JJ
cord-006229-7yoilsho	4294	19	acute	acute	JJ
cord-006229-7yoilsho	4294	20	myeloid	myeloid	JJ
cord-006229-7yoilsho	4294	21	leukaemia	leukaemia	NN
cord-006229-7yoilsho	4294	22	cell	cell	NN
cord-006229-7yoilsho	4294	23	line	line	NN
cord-006229-7yoilsho	4294	24	MUTZ-3	MUTZ-3	NNP
cord-006229-7yoilsho	4294	25	(	(	-LRB-
cord-006229-7yoilsho	4294	26	MUTZ	MUTZ	NNP
cord-006229-7yoilsho	4294	27	-	-	HYPH
cord-006229-7yoilsho	4294	28	LCs	LCs	NNP
cord-006229-7yoilsho	4294	29	)	)	-RRB-
cord-006229-7yoilsho	4294	30	to	to	TO
cord-006229-7yoilsho	4294	31	study	study	VB
cord-006229-7yoilsho	4294	32	TLR	TLR	NNP
cord-006229-7yoilsho	4294	33	-	-	:
cord-006229-7yoilsho	4294	34	and	and	CC
cord-006229-7yoilsho	4294	35	cytokine	cytokine	NN
cord-006229-7yoilsho	4294	36	-	-	HYPH
cord-006229-7yoilsho	4294	37	dependent	dependent	JJ
cord-006229-7yoilsho	4294	38	activation	activation	NN
cord-006229-7yoilsho	4294	39	of	of	IN
cord-006229-7yoilsho	4294	40	epidermal	epidermal	JJ
cord-006229-7yoilsho	4294	41	DCs	dc	NNS
cord-006229-7yoilsho	4294	42	.	.	.
cord-006229-7yoilsho	4295	1	MUTZ	MUTZ	NNP
cord-006229-7yoilsho	4295	2	-	-	HYPH
cord-006229-7yoilsho	4295	3	LCs	LCs	NNP
cord-006229-7yoilsho	4295	4	revealed	reveal	VBD
cord-006229-7yoilsho	4295	5	high	high	JJ
cord-006229-7yoilsho	4295	6	TLR2	TLR2	NNP
cord-006229-7yoilsho	4295	7	expression	expression	NN
cord-006229-7yoilsho	4295	8	and	and	CC
cord-006229-7yoilsho	4295	9	responded	respond	VBD
cord-006229-7yoilsho	4295	10	robustly	robustly	RB
cord-006229-7yoilsho	4295	11	to	to	IN
cord-006229-7yoilsho	4295	12	TLR2	TLR2	NNP
cord-006229-7yoilsho	4295	13	engagement	engagement	NN
cord-006229-7yoilsho	4295	14	,	,	,
cord-006229-7yoilsho	4295	15	confirmed	confirm	VBN
cord-006229-7yoilsho	4295	16	by	by	IN
cord-006229-7yoilsho	4295	17	increased	increase	VBN
cord-006229-7yoilsho	4295	18	CD83	CD83	NNP
cord-006229-7yoilsho	4295	19	and	and	CC
cord-006229-7yoilsho	4295	20	CD86	CD86	NNP
cord-006229-7yoilsho	4295	21	expression	expression	NN
cord-006229-7yoilsho	4295	22	,	,	,
cord-006229-7yoilsho	4295	23	upregulated	upregulate	VBN
cord-006229-7yoilsho	4295	24	IL-6	IL-6	NNP
cord-006229-7yoilsho	4295	25	,	,	,
cord-006229-7yoilsho	4295	26	IL-12p40	IL-12p40	NNP
cord-006229-7yoilsho	4295	27	and	and	CC
cord-006229-7yoilsho	4295	28	IL-23p19	IL-23p19	NNP
cord-006229-7yoilsho	4295	29	mRNA	mRNA	NNP
cord-006229-7yoilsho	4295	30	levels	level	NNS
cord-006229-7yoilsho	4295	31	and	and	CC
cord-006229-7yoilsho	4295	32	IL-8	IL-8	NNP
cord-006229-7yoilsho	4295	33	release	release	NN
cord-006229-7yoilsho	4295	34	.	.	.
cord-006229-7yoilsho	4296	1	TLR2	TLR2	NNP
cord-006229-7yoilsho	4296	2	activation	activation	NN
cord-006229-7yoilsho	4296	3	reduced	reduce	VBD
cord-006229-7yoilsho	4296	4	CCR6	CCR6	NNP
cord-006229-7yoilsho	4296	5	and	and	CC
cord-006229-7yoilsho	4296	6	elevated	elevate	VBD
cord-006229-7yoilsho	4296	7	CCR7	CCR7	NNP
cord-006229-7yoilsho	4296	8	mRNA	mrna	NN
cord-006229-7yoilsho	4296	9	expression	expression	NN
cord-006229-7yoilsho	4296	10	and	and	CC
cord-006229-7yoilsho	4296	11	induced	induce	VBN
cord-006229-7yoilsho	4296	12	migration	migration	NN
cord-006229-7yoilsho	4296	13	of	of	IN
cord-006229-7yoilsho	4296	14	MUTZ	MUTZ	NNP
cord-006229-7yoilsho	4296	15	-	-	HYPH
cord-006229-7yoilsho	4296	16	LCs	LCs	NNP
cord-006229-7yoilsho	4296	17	towards	towards	IN
cord-006229-7yoilsho	4296	18	CCL21	CCL21	NNP
cord-006229-7yoilsho	4296	19	.	.	.
cord-006229-7yoilsho	4297	1	Similar	similar	JJ
cord-006229-7yoilsho	4297	2	results	result	NNS
cord-006229-7yoilsho	4297	3	were	be	VBD
cord-006229-7yoilsho	4297	4	obtained	obtain	VBN
cord-006229-7yoilsho	4297	5	by	by	IN
cord-006229-7yoilsho	4297	6	stimulation	stimulation	NN
cord-006229-7yoilsho	4297	7	with	with	IN
cord-006229-7yoilsho	4297	8	pro	pro	JJ
cord-006229-7yoilsho	4297	9	-	-	JJ
cord-006229-7yoilsho	4297	10	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	4297	11	cytokines	cytokine	NNS
cord-006229-7yoilsho	4298	1	TNF	TNF	NNP
cord-006229-7yoilsho	4298	2	-	-	HYPH
cord-006229-7yoilsho	4298	3	α	α	NNP
cord-006229-7yoilsho	4298	4	and	and	CC
cord-006229-7yoilsho	4298	5	IL	IL	NNP
cord-006229-7yoilsho	4298	6	1β	1β	CD
cord-006229-7yoilsho	4299	1	whereas	whereas	IN
cord-006229-7yoilsho	4299	2	ligands	ligand	NNS
cord-006229-7yoilsho	4299	3	of	of	IN
cord-006229-7yoilsho	4299	4	TLR3	TLR3	NNP
cord-006229-7yoilsho	4299	5	and	and	CC
cord-006229-7yoilsho	4299	6	TLR4	TLR4	NNP
cord-006229-7yoilsho	4299	7	failed	fail	VBD
cord-006229-7yoilsho	4299	8	to	to	TO
cord-006229-7yoilsho	4299	9	induce	induce	VB
cord-006229-7yoilsho	4299	10	a	a	DT
cord-006229-7yoilsho	4299	11	fully	fully	RB
cord-006229-7yoilsho	4299	12	mature	mature	JJ
cord-006229-7yoilsho	4299	13	phenotype	phenotype	NN
cord-006229-7yoilsho	4299	14	.	.	.
cord-006229-7yoilsho	4300	1	Despite	despite	IN
cord-006229-7yoilsho	4300	2	limited	limited	JJ
cord-006229-7yoilsho	4300	3	cytokine	cytokine	NN
cord-006229-7yoilsho	4300	4	gene	gene	NN
cord-006229-7yoilsho	4300	5	expression	expression	NN
cord-006229-7yoilsho	4300	6	and	and	CC
cord-006229-7yoilsho	4300	7	production	production	NN
cord-006229-7yoilsho	4300	8	for	for	IN
cord-006229-7yoilsho	4300	9	TLR2-activated	tlr2-activate	VBN
cord-006229-7yoilsho	4300	10	MUTZ	MUTZ	NNP
cord-006229-7yoilsho	4300	11	-	-	HYPH
cord-006229-7yoilsho	4300	12	LCs	LCs	NNP
cord-006229-7yoilsho	4300	13	,	,	,
cord-006229-7yoilsho	4300	14	co	co	NN
cord-006229-7yoilsho	4300	15	culture	culture	NN
cord-006229-7yoilsho	4300	16	with	with	IN
cord-006229-7yoilsho	4300	17	naive	naive	JJ
cord-006229-7yoilsho	4300	18	CD4	CD4	NNP
cord-006229-7yoilsho	4300	19	+	+	CC
cord-006229-7yoilsho	4300	20	T	t	NN
cord-006229-7yoilsho	4300	21	cells	cell	NNS
cord-006229-7yoilsho	4300	22	led	lead	VBD
cord-006229-7yoilsho	4300	23	to	to	IN
cord-006229-7yoilsho	4300	24	significantly	significantly	RB
cord-006229-7yoilsho	4300	25	increased	increase	VBN
cord-006229-7yoilsho	4300	26	IFN	IFN	NNP
cord-006229-7yoilsho	4300	27	-	-	HYPH
cord-006229-7yoilsho	4300	28	γ	γ	NNP
cord-006229-7yoilsho	4300	29	and	and	CC
cord-006229-7yoilsho	4300	30	IL-22	IL-22	NNP
cord-006229-7yoilsho	4300	31	levels	level	NNS
cord-006229-7yoilsho	4300	32	indicating	indicate	VBG
cord-006229-7yoilsho	4300	33	Th1	th1	CD
cord-006229-7yoilsho	4300	34	differentiation	differentiation	NN
cord-006229-7yoilsho	4300	35	independent	independent	JJ
cord-006229-7yoilsho	4300	36	of	of	IN
cord-006229-7yoilsho	4300	37	IL-12	IL-12	NNP
cord-006229-7yoilsho	4300	38	.	.	.
cord-006229-7yoilsho	4301	1	TLR2-mediated	tlr2-mediate	VBN
cord-006229-7yoilsho	4301	2	effects	effect	NNS
cord-006229-7yoilsho	4301	3	were	be	VBD
cord-006229-7yoilsho	4301	4	blocked	block	VBN
cord-006229-7yoilsho	4301	5	by	by	IN
cord-006229-7yoilsho	4301	6	the	the	DT
cord-006229-7yoilsho	4301	7	putative	putative	JJ
cord-006229-7yoilsho	4301	8	TLR2/1	TLR2/1	NNP
cord-006229-7yoilsho	4301	9	antagonist	antagonist	NN
cord-006229-7yoilsho	4301	10	CU	cu	NN
cord-006229-7yoilsho	4301	11	-	-	HYPH
cord-006229-7yoilsho	4301	12	CPT22	CPT22	NNP
cord-006229-7yoilsho	4301	13	,	,	,
cord-006229-7yoilsho	4301	14	however	however	RB
cord-006229-7yoilsho	4301	15	,	,	,
cord-006229-7yoilsho	4301	16	no	no	DT
cord-006229-7yoilsho	4301	17	selectivity	selectivity	NN
cord-006229-7yoilsho	4301	18	for	for	IN
cord-006229-7yoilsho	4301	19	either	either	DT
cord-006229-7yoilsho	4301	20	TLR2/1	tlr2/1	NN
cord-006229-7yoilsho	4301	21	or	or	CC
cord-006229-7yoilsho	4301	22	TLR2/6	TLR2/6	NNP
cord-006229-7yoilsho	4301	23	was	be	VBD
cord-006229-7yoilsho	4301	24	observed	observe	VBN
cord-006229-7yoilsho	4301	25	.	.	.
cord-006229-7yoilsho	4302	1	Computer	computer	NN
cord-006229-7yoilsho	4302	2	-	-	HYPH
cord-006229-7yoilsho	4302	3	aided	aid	VBN
cord-006229-7yoilsho	4302	4	docking	docking	NN
cord-006229-7yoilsho	4302	5	studies	study	NNS
cord-006229-7yoilsho	4302	6	confirmed	confirm	VBD
cord-006229-7yoilsho	4302	7	non	non	JJ
cord-006229-7yoilsho	4302	8	-	-	JJ
cord-006229-7yoilsho	4302	9	selective	selective	JJ
cord-006229-7yoilsho	4302	10	binding	binding	NN
cord-006229-7yoilsho	4302	11	of	of	IN
cord-006229-7yoilsho	4302	12	the	the	DT
cord-006229-7yoilsho	4302	13	TLR2	TLR2	NNP
cord-006229-7yoilsho	4302	14	antagonist	antagonist	NN
cord-006229-7yoilsho	4302	15	.	.	.
cord-006229-7yoilsho	4303	1	Taken	take	VBN
cord-006229-7yoilsho	4303	2	together	together	RB
cord-006229-7yoilsho	4303	3	,	,	,
cord-006229-7yoilsho	4303	4	our	-PRON-	PRP$
cord-006229-7yoilsho	4303	5	results	result	NNS
cord-006229-7yoilsho	4303	6	indicate	indicate	VBP
cord-006229-7yoilsho	4303	7	a	a	DT
cord-006229-7yoilsho	4303	8	critical	critical	JJ
cord-006229-7yoilsho	4303	9	role	role	NN
cord-006229-7yoilsho	4303	10	for	for	IN
cord-006229-7yoilsho	4303	11	TLR2	TLR2	NNP
cord-006229-7yoilsho	4303	12	signalling	signalling	NN
cord-006229-7yoilsho	4303	13	in	in	IN
cord-006229-7yoilsho	4303	14	MUTZ	MUTZ	NNP
cord-006229-7yoilsho	4303	15	-	-	HYPH
cord-006229-7yoilsho	4303	16	LCs	LCs	NNP
cord-006229-7yoilsho	4303	17	considering	consider	VBG
cord-006229-7yoilsho	4303	18	the	the	DT
cord-006229-7yoilsho	4303	19	leukemic	leukemic	JJ
cord-006229-7yoilsho	4303	20	origin	origin	NN
cord-006229-7yoilsho	4303	21	of	of	IN
cord-006229-7yoilsho	4303	22	the	the	DT
cord-006229-7yoilsho	4303	23	generated	generate	VBN
cord-006229-7yoilsho	4303	24	Langerhans	Langerhans	NNP
cord-006229-7yoilsho	4303	25	-	-	HYPH
cord-006229-7yoilsho	4303	26	like	like	JJ
cord-006229-7yoilsho	4303	27	cells	cell	NNS
cord-006229-7yoilsho	4303	28	.	.	.
cord-006229-7yoilsho	4304	1	The	the	DT
cord-006229-7yoilsho	4304	2	stagnation	stagnation	NN
cord-006229-7yoilsho	4304	3	in	in	IN
cord-006229-7yoilsho	4304	4	the	the	DT
cord-006229-7yoilsho	4304	5	development	development	NN
cord-006229-7yoilsho	4304	6	of	of	IN
cord-006229-7yoilsho	4304	7	new	new	JJ
cord-006229-7yoilsho	4304	8	antibiotics	antibiotic	NNS
cord-006229-7yoilsho	4304	9	during	during	IN
cord-006229-7yoilsho	4304	10	the	the	DT
cord-006229-7yoilsho	4304	11	last	last	JJ
cord-006229-7yoilsho	4304	12	decades	decade	NNS
cord-006229-7yoilsho	4304	13	and	and	CC
cord-006229-7yoilsho	4304	14	the	the	DT
cord-006229-7yoilsho	4304	15	concomitant	concomitant	JJ
cord-006229-7yoilsho	4304	16	high	high	JJ
cord-006229-7yoilsho	4304	17	increase	increase	NN
cord-006229-7yoilsho	4304	18	of	of	IN
cord-006229-7yoilsho	4304	19	resistant	resistant	JJ
cord-006229-7yoilsho	4304	20	bacteria	bacteria	NNS
cord-006229-7yoilsho	4304	21	emphasize	emphasize	VBP
cord-006229-7yoilsho	4304	22	the	the	DT
cord-006229-7yoilsho	4304	23	urgent	urgent	JJ
cord-006229-7yoilsho	4304	24	need	need	NN
cord-006229-7yoilsho	4304	25	for	for	IN
cord-006229-7yoilsho	4304	26	new	new	JJ
cord-006229-7yoilsho	4304	27	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	4304	28	options	option	NNS
cord-006229-7yoilsho	4304	29	.	.	.
cord-006229-7yoilsho	4305	1	Antimicrobial	antimicrobial	JJ
cord-006229-7yoilsho	4305	2	peptides	peptide	NNS
cord-006229-7yoilsho	4305	3	are	be	VBP
cord-006229-7yoilsho	4305	4	promising	promise	VBG
cord-006229-7yoilsho	4305	5	agents	agent	NNS
cord-006229-7yoilsho	4305	6	for	for	IN
cord-006229-7yoilsho	4305	7	the	the	DT
cord-006229-7yoilsho	4305	8	treatment	treatment	NN
cord-006229-7yoilsho	4305	9	of	of	IN
cord-006229-7yoilsho	4305	10	bacterial	bacterial	JJ
cord-006229-7yoilsho	4305	11	infections	infection	NNS
cord-006229-7yoilsho	4305	12	and	and	CC
cord-006229-7yoilsho	4305	13	recent	recent	JJ
cord-006229-7yoilsho	4305	14	studies	study	NNS
cord-006229-7yoilsho	4305	15	indicate	indicate	VBP
cord-006229-7yoilsho	4305	16	that	that	IN
cord-006229-7yoilsho	4305	17	Pep19	Pep19	NNP
cord-006229-7yoilsho	4305	18	-	-	HYPH
cord-006229-7yoilsho	4305	19	2.5	2.5	CD
cord-006229-7yoilsho	4305	20	,	,	,
cord-006229-7yoilsho	4305	21	a	a	DT
cord-006229-7yoilsho	4305	22	synthetic	synthetic	JJ
cord-006229-7yoilsho	4305	23	antimicrobial	antimicrobial	NN
cord-006229-7yoilsho	4305	24	and	and	CC
cord-006229-7yoilsho	4305	25	LPS	LPS	NNP
cord-006229-7yoilsho	4305	26	-	-	HYPH
cord-006229-7yoilsho	4305	27	neutralizing	neutralize	VBG
cord-006229-7yoilsho	4305	28	peptide	peptide	NN
cord-006229-7yoilsho	4305	29	(	(	-LRB-
cord-006229-7yoilsho	4305	30	SALP	SALP	NNP
cord-006229-7yoilsho	4305	31	)	)	-RRB-
cord-006229-7yoilsho	4305	32	,	,	,
cord-006229-7yoilsho	4305	33	efficiently	efficiently	RB
cord-006229-7yoilsho	4305	34	neutralizes	neutralize	VBZ
cord-006229-7yoilsho	4305	35	pathogenicity	pathogenicity	NN
cord-006229-7yoilsho	4305	36	factors	factor	NNS
cord-006229-7yoilsho	4305	37	of	of	IN
cord-006229-7yoilsho	4305	38	Gram	gram	NN
cord-006229-7yoilsho	4305	39	-	-	HYPH
cord-006229-7yoilsho	4305	40	negative	negative	JJ
cord-006229-7yoilsho	4305	41	and	and	CC
cord-006229-7yoilsho	4305	42	Gram	gram	NN
cord-006229-7yoilsho	4305	43	-	-	HYPH
cord-006229-7yoilsho	4305	44	positive	positive	JJ
cord-006229-7yoilsho	4305	45	bacteria	bacteria	NNS
cord-006229-7yoilsho	4305	46	and	and	CC
cord-006229-7yoilsho	4305	47	protects	protect	VBZ
cord-006229-7yoilsho	4305	48	against	against	IN
cord-006229-7yoilsho	4305	49	sepsis	sepsis	NN
cord-006229-7yoilsho	4305	50	.	.	.
cord-006229-7yoilsho	4306	1	In	in	IN
cord-006229-7yoilsho	4306	2	the	the	DT
cord-006229-7yoilsho	4306	3	present	present	JJ
cord-006229-7yoilsho	4306	4	study	study	NN
cord-006229-7yoilsho	4306	5	,	,	,
cord-006229-7yoilsho	4306	6	we	-PRON-	PRP
cord-006229-7yoilsho	4306	7	investigated	investigate	VBD
cord-006229-7yoilsho	4306	8	the	the	DT
cord-006229-7yoilsho	4306	9	potential	potential	NN
cord-006229-7yoilsho	4306	10	of	of	IN
cord-006229-7yoilsho	4306	11	Pep19	Pep19	NNP
cord-006229-7yoilsho	4306	12	-	-	HYPH
cord-006229-7yoilsho	4306	13	2.5	2.5	CD
cord-006229-7yoilsho	4306	14	and	and	CC
cord-006229-7yoilsho	4306	15	the	the	DT
cord-006229-7yoilsho	4306	16	structurally	structurally	RB
cord-006229-7yoilsho	4306	17	related	relate	VBN
cord-006229-7yoilsho	4306	18	compound	compound	NN
cord-006229-7yoilsho	4306	19	Pep19	Pep19	NNP
cord-006229-7yoilsho	4306	20	-	-	HYPH
cord-006229-7yoilsho	4306	21	4LF	4LF	NNP
cord-006229-7yoilsho	4306	22	for	for	IN
cord-006229-7yoilsho	4306	23	their	-PRON-	PRP$
cord-006229-7yoilsho	4306	24	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	4306	25	application	application	NN
cord-006229-7yoilsho	4306	26	in	in	IN
cord-006229-7yoilsho	4306	27	bacterial	bacterial	JJ
cord-006229-7yoilsho	4306	28	skin	skin	NN
cord-006229-7yoilsho	4306	29	infections	infection	NNS
cord-006229-7yoilsho	4306	30	.	.	.
cord-006229-7yoilsho	4307	1	Primary	primary	JJ
cord-006229-7yoilsho	4307	2	human	human	JJ
cord-006229-7yoilsho	4307	3	keratinocytes	keratinocyte	NNS
cord-006229-7yoilsho	4307	4	responded	respond	VBD
cord-006229-7yoilsho	4307	5	to	to	IN
cord-006229-7yoilsho	4307	6	TLR2	TLR2	NNP
cord-006229-7yoilsho	4307	7	(	(	-LRB-
cord-006229-7yoilsho	4307	8	FSL-1	FSL-1	NNP
cord-006229-7yoilsho	4307	9	)	)	-RRB-
cord-006229-7yoilsho	4307	10	but	but	CC
cord-006229-7yoilsho	4307	11	not	not	RB
cord-006229-7yoilsho	4307	12	TLR4	TLR4	NNP
cord-006229-7yoilsho	4307	13	(	(	-LRB-
cord-006229-7yoilsho	4307	14	LPS	LPS	NNP
cord-006229-7yoilsho	4307	15	)	)	-RRB-
cord-006229-7yoilsho	4307	16	activation	activation	NN
cord-006229-7yoilsho	4307	17	by	by	IN
cord-006229-7yoilsho	4307	18	increased	increase	VBN
cord-006229-7yoilsho	4307	19	IL-8	il-8	NN
cord-006229-7yoilsho	4307	20	production	production	NN
cord-006229-7yoilsho	4307	21	,	,	,
cord-006229-7yoilsho	4307	22	as	as	IN
cord-006229-7yoilsho	4307	23	determined	determine	VBN
cord-006229-7yoilsho	4307	24	by	by	IN
cord-006229-7yoilsho	4307	25	ELISA	ELISA	NNP
cord-006229-7yoilsho	4307	26	.	.	.
cord-006229-7yoilsho	4308	1	Western	western	JJ
cord-006229-7yoilsho	4308	2	blot	blot	NN
cord-006229-7yoilsho	4308	3	analysis	analysis	NN
cord-006229-7yoilsho	4308	4	showed	show	VBD
cord-006229-7yoilsho	4308	5	that	that	IN
cord-006229-7yoilsho	4308	6	both	both	DT
cord-006229-7yoilsho	4308	7	SALPs	salp	NNS
cord-006229-7yoilsho	4308	8	inhibited	inhibit	VBD
cord-006229-7yoilsho	4308	9	FSL-1-induced	fsl-1-induce	VBN
cord-006229-7yoilsho	4308	10	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	4308	11	of	of	IN
cord-006229-7yoilsho	4308	12	NF	nf	NN
cord-006229-7yoilsho	4308	13	-	-	HYPH
cord-006229-7yoilsho	4308	14	κB	κB	NNP
cord-006229-7yoilsho	4308	15	p65	p65	NN
cord-006229-7yoilsho	4308	16	and	and	CC
cord-006229-7yoilsho	4308	17	p38	p38	NN
cord-006229-7yoilsho	4308	18	MAPK	MAPK	NNP
cord-006229-7yoilsho	4308	19	.	.	.
cord-006229-7yoilsho	4309	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	4309	2	,	,	,
cord-006229-7yoilsho	4309	3	the	the	DT
cord-006229-7yoilsho	4309	4	peptides	peptide	NNS
cord-006229-7yoilsho	4309	5	significantly	significantly	RB
cord-006229-7yoilsho	4309	6	reduced	reduce	VBN
cord-006229-7yoilsho	4309	7	IL-8	IL-8	NNP
cord-006229-7yoilsho	4309	8	release	release	NN
cord-006229-7yoilsho	4309	9	and	and	CC
cord-006229-7yoilsho	4309	10	gene	gene	NN
cord-006229-7yoilsho	4309	11	expression	expression	NN
cord-006229-7yoilsho	4309	12	of	of	IN
cord-006229-7yoilsho	4309	13	IL-1β	IL-1β	NNP
cord-006229-7yoilsho	4309	14	,	,	,
cord-006229-7yoilsho	4309	15	CCL2	CCL2	NNP
cord-006229-7yoilsho	4309	16	(	(	-LRB-
cord-006229-7yoilsho	4309	17	MCP-1	MCP-1	NNP
cord-006229-7yoilsho	4309	18	)	)	-RRB-
cord-006229-7yoilsho	4309	19	and	and	CC
cord-006229-7yoilsho	4309	20	hBD-2	hBD-2	VBD
cord-006229-7yoilsho	4309	21	as	as	IN
cord-006229-7yoilsho	4309	22	assessed	assess	VBN
cord-006229-7yoilsho	4309	23	by	by	IN
cord-006229-7yoilsho	4309	24	qPCR	qPCR	NNP
cord-006229-7yoilsho	4309	25	.	.	.
cord-006229-7yoilsho	4310	1	No	no	DT
cord-006229-7yoilsho	4310	2	cytotoxicity	cytotoxicity	NN
cord-006229-7yoilsho	4310	3	(	(	-LRB-
cord-006229-7yoilsho	4310	4	MTT	MTT	NNP
cord-006229-7yoilsho	4310	5	test	test	NN
cord-006229-7yoilsho	4310	6	)	)	-RRB-
cord-006229-7yoilsho	4310	7	was	be	VBD
cord-006229-7yoilsho	4310	8	observed	observe	VBN
cord-006229-7yoilsho	4310	9	at	at	IN
cord-006229-7yoilsho	4310	10	SALP	SALP	NNP
cord-006229-7yoilsho	4310	11	concentrations	concentration	NNS
cord-006229-7yoilsho	4310	12	below	below	IN
cord-006229-7yoilsho	4310	13	10	10	CD
cord-006229-7yoilsho	4310	14	µg	µg	NN
cord-006229-7yoilsho	4310	15	/	/	SYM
cord-006229-7yoilsho	4310	16	ml	ml	NN
cord-006229-7yoilsho	4310	17	.	.	.
cord-006229-7yoilsho	4311	1	In	in	IN
cord-006229-7yoilsho	4311	2	LPS	LPS	NNP
cord-006229-7yoilsho	4311	3	-	-	HYPH
cord-006229-7yoilsho	4311	4	stimulated	stimulate	VBN
cord-006229-7yoilsho	4311	5	monocyte	monocyte	NN
cord-006229-7yoilsho	4311	6	-	-	HYPH
cord-006229-7yoilsho	4311	7	derived	derive	VBN
cord-006229-7yoilsho	4311	8	dendritic	dendritic	JJ
cord-006229-7yoilsho	4311	9	cells	cell	NNS
cord-006229-7yoilsho	4311	10	,	,	,
cord-006229-7yoilsho	4311	11	the	the	DT
cord-006229-7yoilsho	4311	12	peptides	peptide	NNS
cord-006229-7yoilsho	4311	13	blocked	block	VBD
cord-006229-7yoilsho	4311	14	IL-6	IL-6	NNP
cord-006229-7yoilsho	4311	15	secretion	secretion	NN
cord-006229-7yoilsho	4311	16	,	,	,
cord-006229-7yoilsho	4311	17	downregulated	downregulated	JJ
cord-006229-7yoilsho	4311	18	expression	expression	NN
cord-006229-7yoilsho	4311	19	of	of	IN
cord-006229-7yoilsho	4311	20	the	the	DT
cord-006229-7yoilsho	4311	21	maturation	maturation	NN
cord-006229-7yoilsho	4311	22	markers	marker	VBZ
cord-006229-7yoilsho	4311	23	CD83	CD83	NNP
cord-006229-7yoilsho	4311	24	and	and	CC
cord-006229-7yoilsho	4311	25	CD86	CD86	NNP
cord-006229-7yoilsho	4311	26	,	,	,
cord-006229-7yoilsho	4311	27	as	as	IN
cord-006229-7yoilsho	4311	28	analysed	analyse	VBN
cord-006229-7yoilsho	4311	29	by	by	IN
cord-006229-7yoilsho	4311	30	flow	flow	NN
cord-006229-7yoilsho	4311	31	cytometry	cytometry	NN
cord-006229-7yoilsho	4311	32	,	,	,
cord-006229-7yoilsho	4311	33	and	and	CC
cord-006229-7yoilsho	4311	34	inhibited	inhibit	VBN
cord-006229-7yoilsho	4311	35	CCR7-dependent	CCR7-dependent	NNP
cord-006229-7yoilsho	4311	36	migration	migration	NN
cord-006229-7yoilsho	4311	37	capacity	capacity	NN
cord-006229-7yoilsho	4311	38	.	.	.
cord-006229-7yoilsho	4312	1	Similarly	similarly	RB
cord-006229-7yoilsho	4312	2	,	,	,
cord-006229-7yoilsho	4312	3	monocyte	monocyte	NNP
cord-006229-7yoilsho	4312	4	-	-	HYPH
cord-006229-7yoilsho	4312	5	derived	derive	VBN
cord-006229-7yoilsho	4312	6	Langerhans	Langerhans	NNP
cord-006229-7yoilsho	4312	7	-	-	HYPH
cord-006229-7yoilsho	4312	8	like	like	JJ
cord-006229-7yoilsho	4312	9	cells	cell	NNS
cord-006229-7yoilsho	4312	10	activated	activate	VBN
cord-006229-7yoilsho	4312	11	with	with	IN
cord-006229-7yoilsho	4312	12	LPS	LPS	NNP
cord-006229-7yoilsho	4312	13	and	and	CC
cord-006229-7yoilsho	4312	14	pro	pro	JJ
cord-006229-7yoilsho	4312	15	-	-	JJ
cord-006229-7yoilsho	4312	16	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	4312	17	cytokines	cytokine	NNS
cord-006229-7yoilsho	4312	18	showed	show	VBD
cord-006229-7yoilsho	4312	19	reduced	reduce	VBN
cord-006229-7yoilsho	4312	20	IL-6	IL-6	NNP
cord-006229-7yoilsho	4312	21	levels	level	NNS
cord-006229-7yoilsho	4312	22	and	and	CC
cord-006229-7yoilsho	4312	23	CD83	CD83	NNP
cord-006229-7yoilsho	4312	24	/	/	SYM
cord-006229-7yoilsho	4312	25	CD86	CD86	NNP
cord-006229-7yoilsho	4312	26	expression	expression	NN
cord-006229-7yoilsho	4312	27	in	in	IN
cord-006229-7yoilsho	4312	28	the	the	DT
cord-006229-7yoilsho	4312	29	presence	presence	NN
cord-006229-7yoilsho	4312	30	of	of	IN
cord-006229-7yoilsho	4312	31	SALPs	salp	NNS
cord-006229-7yoilsho	4312	32	.	.	.
cord-006229-7yoilsho	4313	1	In	in	IN
cord-006229-7yoilsho	4313	2	addition	addition	NN
cord-006229-7yoilsho	4313	3	to	to	IN
cord-006229-7yoilsho	4313	4	acute	acute	JJ
cord-006229-7yoilsho	4313	5	inflammation	inflammation	NN
cord-006229-7yoilsho	4313	6	,	,	,
cord-006229-7yoilsho	4313	7	bacterial	bacterial	JJ
cord-006229-7yoilsho	4313	8	infections	infection	NNS
cord-006229-7yoilsho	4313	9	often	often	RB
cord-006229-7yoilsho	4313	10	result	result	VBP
cord-006229-7yoilsho	4313	11	in	in	IN
cord-006229-7yoilsho	4313	12	impaired	impaired	JJ
cord-006229-7yoilsho	4313	13	wound	wound	NN
cord-006229-7yoilsho	4313	14	healing	healing	NN
cord-006229-7yoilsho	4313	15	.	.	.
cord-006229-7yoilsho	4314	1	Since	since	IN
cord-006229-7yoilsho	4314	2	re	re	NN
cord-006229-7yoilsho	4314	3	-	-	NN
cord-006229-7yoilsho	4314	4	epithelialization	epithelialization	NN
cord-006229-7yoilsho	4314	5	is	be	VBZ
cord-006229-7yoilsho	4314	6	a	a	DT
cord-006229-7yoilsho	4314	7	critical	critical	JJ
cord-006229-7yoilsho	4314	8	step	step	NN
cord-006229-7yoilsho	4314	9	in	in	IN
cord-006229-7yoilsho	4314	10	wound	wound	NN
cord-006229-7yoilsho	4314	11	repair	repair	NN
cord-006229-7yoilsho	4314	12	,	,	,
cord-006229-7yoilsho	4314	13	we	-PRON-	PRP
cord-006229-7yoilsho	4314	14	tested	test	VBD
cord-006229-7yoilsho	4314	15	whether	whether	IN
cord-006229-7yoilsho	4314	16	Pep	Pep	NNP
cord-006229-7yoilsho	4314	17	19	19	CD
cord-006229-7yoilsho	4314	18	-	-	SYM
cord-006229-7yoilsho	4314	19	2.5	2.5	CD
cord-006229-7yoilsho	4314	20	affects	affect	VBZ
cord-006229-7yoilsho	4314	21	keratinocyte	keratinocyte	NNP
cord-006229-7yoilsho	4314	22	migration	migration	NN
cord-006229-7yoilsho	4314	23	using	use	VBG
cord-006229-7yoilsho	4314	24	the	the	DT
cord-006229-7yoilsho	4314	25	scratch	scratch	NN
cord-006229-7yoilsho	4314	26	wound	wound	NN
cord-006229-7yoilsho	4314	27	assay	assay	NN
cord-006229-7yoilsho	4314	28	.	.	.
cord-006229-7yoilsho	4315	1	The	the	DT
cord-006229-7yoilsho	4315	2	peptide	peptide	NN
cord-006229-7yoilsho	4315	3	markedly	markedly	RB
cord-006229-7yoilsho	4315	4	promoted	promote	VBD
cord-006229-7yoilsho	4315	5	cell	cell	NN
cord-006229-7yoilsho	4315	6	migration	migration	NN
cord-006229-7yoilsho	4315	7	and	and	CC
cord-006229-7yoilsho	4315	8	accelerated	accelerate	VBN
cord-006229-7yoilsho	4315	9	artificial	artificial	JJ
cord-006229-7yoilsho	4315	10	wound	wound	NN
cord-006229-7yoilsho	4315	11	closure	closure	NN
cord-006229-7yoilsho	4315	12	at	at	IN
cord-006229-7yoilsho	4315	13	concentrations	concentration	NNS
cord-006229-7yoilsho	4315	14	as	as	RB
cord-006229-7yoilsho	4315	15	low	low	JJ
cord-006229-7yoilsho	4315	16	as	as	IN
cord-006229-7yoilsho	4315	17	1	1	CD
cord-006229-7yoilsho	4315	18	ng	ng	NN
cord-006229-7yoilsho	4315	19	/	/	SYM
cord-006229-7yoilsho	4315	20	ml	ml	NN
cord-006229-7yoilsho	4315	21	and	and	CC
cord-006229-7yoilsho	4315	22	was	be	VBD
cord-006229-7yoilsho	4315	23	equipotent	equipotent	JJ
cord-006229-7yoilsho	4315	24	to	to	IN
cord-006229-7yoilsho	4315	25	TGF	TGF	NNP
cord-006229-7yoilsho	4315	26	-	-	HYPH
cord-006229-7yoilsho	4315	27	β	β	NNP
cord-006229-7yoilsho	4315	28	.	.	.
cord-006229-7yoilsho	4316	1	Conclusively	conclusively	RB
cord-006229-7yoilsho	4316	2	,	,	,
cord-006229-7yoilsho	4316	3	our	-PRON-	PRP$
cord-006229-7yoilsho	4316	4	data	datum	NNS
cord-006229-7yoilsho	4316	5	suggest	suggest	VBP
cord-006229-7yoilsho	4316	6	a	a	DT
cord-006229-7yoilsho	4316	7	novel	novel	JJ
cord-006229-7yoilsho	4316	8	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	4316	9	target	target	NN
cord-006229-7yoilsho	4316	10	for	for	IN
cord-006229-7yoilsho	4316	11	the	the	DT
cord-006229-7yoilsho	4316	12	treatment	treatment	NN
cord-006229-7yoilsho	4316	13	of	of	IN
cord-006229-7yoilsho	4316	14	patients	patient	NNS
cord-006229-7yoilsho	4316	15	with	with	IN
cord-006229-7yoilsho	4316	16	acute	acute	JJ
cord-006229-7yoilsho	4316	17	and	and	CC
cord-006229-7yoilsho	4316	18	chronic	chronic	JJ
cord-006229-7yoilsho	4316	19	skin	skin	NN
cord-006229-7yoilsho	4316	20	infections	infection	NNS
cord-006229-7yoilsho	4316	21	.	.	.
cord-006229-7yoilsho	4317	1	Recently	recently	RB
cord-006229-7yoilsho	4317	2	,	,	,
cord-006229-7yoilsho	4317	3	we	-PRON-	PRP
cord-006229-7yoilsho	4317	4	and	and	CC
cord-006229-7yoilsho	4317	5	others	other	NNS
cord-006229-7yoilsho	4317	6	have	have	VBP
cord-006229-7yoilsho	4317	7	shown	show	VBN
cord-006229-7yoilsho	4317	8	that	that	IN
cord-006229-7yoilsho	4317	9	the	the	DT
cord-006229-7yoilsho	4317	10	transcription	transcription	NN
cord-006229-7yoilsho	4317	11	factor	factor	NN
cord-006229-7yoilsho	4317	12	nuclear	nuclear	JJ
cord-006229-7yoilsho	4317	13	factor	factor	NN
cord-006229-7yoilsho	4317	14	erythroid	erythroid	NN
cord-006229-7yoilsho	4317	15	2-related	2-related	CD
cord-006229-7yoilsho	4317	16	factor	factor	NN
cord-006229-7yoilsho	4317	17	2	2	CD
cord-006229-7yoilsho	4317	18	(	(	-LRB-
cord-006229-7yoilsho	4317	19	Nrf2	Nrf2	NNP
cord-006229-7yoilsho	4317	20	)	)	-RRB-
cord-006229-7yoilsho	4317	21	,	,	,
cord-006229-7yoilsho	4317	22	a	a	DT
cord-006229-7yoilsho	4317	23	major	major	JJ
cord-006229-7yoilsho	4317	24	regulator	regulator	NN
cord-006229-7yoilsho	4317	25	of	of	IN
cord-006229-7yoilsho	4317	26	the	the	DT
cord-006229-7yoilsho	4317	27	cellular	cellular	JJ
cord-006229-7yoilsho	4317	28	antioxidant	antioxidant	NN
cord-006229-7yoilsho	4317	29	defence	defence	NN
cord-006229-7yoilsho	4317	30	system	system	NN
cord-006229-7yoilsho	4317	31	,	,	,
cord-006229-7yoilsho	4317	32	is	be	VBZ
cord-006229-7yoilsho	4317	33	activated	activate	VBN
cord-006229-7yoilsho	4317	34	by	by	IN
cord-006229-7yoilsho	4317	35	mechanical	mechanical	JJ
cord-006229-7yoilsho	4317	36	ventilation	ventilation	NN
cord-006229-7yoilsho	4317	37	.	.	.
cord-006229-7yoilsho	4318	1	During	during	IN
cord-006229-7yoilsho	4318	2	ventilator	ventilator	NN
cord-006229-7yoilsho	4318	3	-	-	HYPH
cord-006229-7yoilsho	4318	4	induced	induce	VBN
cord-006229-7yoilsho	4318	5	lung	lung	NN
cord-006229-7yoilsho	4318	6	injury	injury	NN
cord-006229-7yoilsho	4318	7	,	,	,
cord-006229-7yoilsho	4318	8	Nrf2	Nrf2	NNP
cord-006229-7yoilsho	4318	9	exerts	exert	VBZ
cord-006229-7yoilsho	4318	10	a	a	DT
cord-006229-7yoilsho	4318	11	protective	protective	JJ
cord-006229-7yoilsho	4318	12	role	role	NN
cord-006229-7yoilsho	4318	13	by	by	IN
cord-006229-7yoilsho	4318	14	interaction	interaction	NN
cord-006229-7yoilsho	4318	15	with	with	IN
cord-006229-7yoilsho	4318	16	the	the	DT
cord-006229-7yoilsho	4318	17	stretch	stretch	NN
cord-006229-7yoilsho	4318	18	-	-	HYPH
cord-006229-7yoilsho	4318	19	induced	induce	VBN
cord-006229-7yoilsho	4318	20	growth	growth	NN
cord-006229-7yoilsho	4318	21	factor	factor	NN
cord-006229-7yoilsho	4318	22	amphiregulin	amphiregulin	NN
cord-006229-7yoilsho	4318	23	.	.	.
cord-006229-7yoilsho	4319	1	In	in	IN
cord-006229-7yoilsho	4319	2	the	the	DT
cord-006229-7yoilsho	4319	3	current	current	JJ
cord-006229-7yoilsho	4319	4	study	study	NN
cord-006229-7yoilsho	4319	5	,	,	,
cord-006229-7yoilsho	4319	6	we	-PRON-	PRP
cord-006229-7yoilsho	4319	7	aimed	aim	VBD
cord-006229-7yoilsho	4319	8	to	to	TO
cord-006229-7yoilsho	4319	9	investigate	investigate	VB
cord-006229-7yoilsho	4319	10	the	the	DT
cord-006229-7yoilsho	4319	11	role	role	NN
cord-006229-7yoilsho	4319	12	of	of	IN
cord-006229-7yoilsho	4319	13	Nrf2	Nrf2	NNP
cord-006229-7yoilsho	4319	14	in	in	IN
cord-006229-7yoilsho	4319	15	acid	acid	NN
cord-006229-7yoilsho	4319	16	-	-	HYPH
cord-006229-7yoilsho	4319	17	induced	induce	VBN
cord-006229-7yoilsho	4319	18	lung	lung	NN
cord-006229-7yoilsho	4319	19	injury	injury	NN
cord-006229-7yoilsho	4319	20	,	,	,
cord-006229-7yoilsho	4319	21	a	a	DT
cord-006229-7yoilsho	4319	22	model	model	NN
cord-006229-7yoilsho	4319	23	for	for	IN
cord-006229-7yoilsho	4319	24	aspiration	aspiration	NN
cord-006229-7yoilsho	4319	25	-	-	HYPH
cord-006229-7yoilsho	4319	26	induced	induce	VBN
cord-006229-7yoilsho	4319	27	ARDS	ARDS	NNP
cord-006229-7yoilsho	4319	28	.	.	.
cord-006229-7yoilsho	4320	1	Methods	method	NNS
cord-006229-7yoilsho	4320	2	:	:	:
cord-006229-7yoilsho	4321	1	Nrf2-deficient	nrf2-deficient	NN
cord-006229-7yoilsho	4322	1	(	(	-LRB-
cord-006229-7yoilsho	4322	2	Nrf2	Nrf2	NNP
cord-006229-7yoilsho	4322	3	-/-	-/-	NNP
cord-006229-7yoilsho	4322	4	)	)	-RRB-
cord-006229-7yoilsho	4322	5	mice	mouse	NNS
cord-006229-7yoilsho	4322	6	and	and	CC
cord-006229-7yoilsho	4322	7	wild	wild	JJ
cord-006229-7yoilsho	4322	8	type	type	NN
cord-006229-7yoilsho	4322	9	(	(	-LRB-
cord-006229-7yoilsho	4322	10	WT	WT	NNP
cord-006229-7yoilsho	4322	11	)	)	-RRB-
cord-006229-7yoilsho	4322	12	littermates	littermate	NNS
cord-006229-7yoilsho	4322	13	were	be	VBD
cord-006229-7yoilsho	4322	14	tracheotomised	tracheotomise	VBN
cord-006229-7yoilsho	4322	15	and	and	CC
cord-006229-7yoilsho	4322	16	ventilated	ventilate	VBN
cord-006229-7yoilsho	4322	17	for	for	IN
cord-006229-7yoilsho	4322	18	30min	30min	NN
cord-006229-7yoilsho	4323	1	(	(	-LRB-
cord-006229-7yoilsho	4323	2	V	V	NNP
cord-006229-7yoilsho	4323	3	T	t	NN
cord-006229-7yoilsho	4323	4	=	=	SYM
cord-006229-7yoilsho	4323	5	16mL	16ml	CD
cord-006229-7yoilsho	4323	6	/	/	SYM
cord-006229-7yoilsho	4323	7	kg	kg	NN
cord-006229-7yoilsho	4323	8	,	,	,
cord-006229-7yoilsho	4323	9	f=90min	f=90min	NNP
cord-006229-7yoilsho	4323	10	-1	-1	NN
cord-006229-7yoilsho	4323	11	,	,	,
cord-006229-7yoilsho	4323	12	PEEP=2cmH	peep=2cmh	XX
cord-006229-7yoilsho	4324	1	2	2	LS
cord-006229-7yoilsho	4324	2	O	o	NN
cord-006229-7yoilsho	4324	3	,	,	,
cord-006229-7yoilsho	4324	4	FiO	fio	NN
cord-006229-7yoilsho	4324	5	2	2	CD
cord-006229-7yoilsho	4324	6	=	=	SYM
cord-006229-7yoilsho	4324	7	0.3	0.3	CD
cord-006229-7yoilsho	4324	8	)	)	-RRB-
cord-006229-7yoilsho	4324	9	,	,	,
cord-006229-7yoilsho	4324	10	before	before	IN
cord-006229-7yoilsho	4324	11	50	50	CD
cord-006229-7yoilsho	4324	12	µL	µl	XX
cord-006229-7yoilsho	4325	1	hydrochloric	hydrochloric	JJ
cord-006229-7yoilsho	4325	2	acid	acid	NN
cord-006229-7yoilsho	4325	3	(	(	-LRB-
cord-006229-7yoilsho	4325	4	HCl	hcl	NN
cord-006229-7yoilsho	4325	5	)	)	-RRB-
cord-006229-7yoilsho	4325	6	with	with	IN
cord-006229-7yoilsho	4325	7	pH=1.5	pH=1.5	NNP
cord-006229-7yoilsho	4325	8	or	or	CC
cord-006229-7yoilsho	4325	9	pH=1.3	pH=1.3	NNP
cord-006229-7yoilsho	4325	10	were	be	VBD
cord-006229-7yoilsho	4325	11	instilled	instill	VBN
cord-006229-7yoilsho	4325	12	intratracheally	intratracheally	RB
cord-006229-7yoilsho	4325	13	,	,	,
cord-006229-7yoilsho	4325	14	controls	control	NNS
cord-006229-7yoilsho	4325	15	received	receive	VBD
cord-006229-7yoilsho	4325	16	NaCl	NaCl	NNP
cord-006229-7yoilsho	4325	17	.	.	.
cord-006229-7yoilsho	4326	1	Mice	mouse	NNS
cord-006229-7yoilsho	4326	2	were	be	VBD
cord-006229-7yoilsho	4326	3	then	then	RB
cord-006229-7yoilsho	4326	4	ventilated	ventilate	VBN
cord-006229-7yoilsho	4326	5	for	for	IN
cord-006229-7yoilsho	4326	6	further	further	JJ
cord-006229-7yoilsho	4326	7	6h	6h	CD
cord-006229-7yoilsho	4326	8	under	under	IN
cord-006229-7yoilsho	4326	9	monitoring	monitoring	NN
cord-006229-7yoilsho	4326	10	of	of	IN
cord-006229-7yoilsho	4326	11	lung	lung	NN
cord-006229-7yoilsho	4326	12	mechanics	mechanic	NNS
cord-006229-7yoilsho	4326	13	and	and	CC
cord-006229-7yoilsho	4326	14	vital	vital	JJ
cord-006229-7yoilsho	4326	15	parameters	parameter	NNS
cord-006229-7yoilsho	4326	16	.	.	.
cord-006229-7yoilsho	4327	1	Blood	blood	NN
cord-006229-7yoilsho	4327	2	gases	gas	NNS
cord-006229-7yoilsho	4327	3	as	as	RB
cord-006229-7yoilsho	4327	4	well	well	RB
cord-006229-7yoilsho	4327	5	as	as	IN
cord-006229-7yoilsho	4327	6	proinflammatory	proinflammatory	JJ
cord-006229-7yoilsho	4327	7	mediators	mediator	NNS
cord-006229-7yoilsho	4327	8	,	,	,
cord-006229-7yoilsho	4327	9	neutrophil	neutrophil	NN
cord-006229-7yoilsho	4327	10	recruitment	recruitment	NN
cord-006229-7yoilsho	4327	11	and	and	CC
cord-006229-7yoilsho	4327	12	microvascular	microvascular	JJ
cord-006229-7yoilsho	4327	13	permeability	permeability	NN
cord-006229-7yoilsho	4327	14	were	be	VBD
cord-006229-7yoilsho	4327	15	examined	examine	VBN
cord-006229-7yoilsho	4327	16	to	to	TO
cord-006229-7yoilsho	4327	17	assess	assess	VB
cord-006229-7yoilsho	4327	18	lung	lung	NN
cord-006229-7yoilsho	4327	19	injury	injury	NN
cord-006229-7yoilsho	4327	20	.	.	.
cord-006229-7yoilsho	4328	1	Results	result	NNS
cord-006229-7yoilsho	4328	2	:	:	:
cord-006229-7yoilsho	4329	1	Instillation	Instillation	NNP
cord-006229-7yoilsho	4329	2	of	of	IN
cord-006229-7yoilsho	4329	3	HCl	HCl	NNP
cord-006229-7yoilsho	4329	4	pH=1.5	pH=1.5	NNP
cord-006229-7yoilsho	4329	5	induced	induce	VBD
cord-006229-7yoilsho	4329	6	mild	mild	JJ
cord-006229-7yoilsho	4329	7	lung	lung	NN
cord-006229-7yoilsho	4329	8	injury	injury	NN
cord-006229-7yoilsho	4329	9	,	,	,
cord-006229-7yoilsho	4329	10	indicated	indicate	VBN
cord-006229-7yoilsho	4329	11	by	by	IN
cord-006229-7yoilsho	4329	12	hypoxemia	hypoxemia	NN
cord-006229-7yoilsho	4329	13	(	(	-LRB-
cord-006229-7yoilsho	4329	14	pO	po	NN
cord-006229-7yoilsho	4329	15	2	2	CD
cord-006229-7yoilsho	4329	16	/FiO	/fio	SYM
cord-006229-7yoilsho	4329	17	2	2	CD
cord-006229-7yoilsho	4329	18	~300mmHg	~300mmHg	NFP
cord-006229-7yoilsho	4329	19	)	)	-RRB-
cord-006229-7yoilsho	4329	20	and	and	CC
cord-006229-7yoilsho	4329	21	continuously	continuously	RB
cord-006229-7yoilsho	4329	22	increasing	increase	VBG
cord-006229-7yoilsho	4329	23	lung	lung	NN
cord-006229-7yoilsho	4329	24	tissue	tissue	NN
cord-006229-7yoilsho	4329	25	elastance	elastance	NN
cord-006229-7yoilsho	4329	26	(	(	-LRB-
cord-006229-7yoilsho	4329	27	stiffness	stiffness	NN
cord-006229-7yoilsho	4329	28	)	)	-RRB-
cord-006229-7yoilsho	4329	29	,	,	,
cord-006229-7yoilsho	4329	30	from	from	IN
cord-006229-7yoilsho	4329	31	which	which	WDT
cord-006229-7yoilsho	4329	32	Nrf2	Nrf2	NNP
cord-006229-7yoilsho	4329	33	-/mice	-/mice	:
cord-006229-7yoilsho	4329	34	were	be	VBD
cord-006229-7yoilsho	4329	35	protected	protect	VBN
cord-006229-7yoilsho	4329	36	.	.	.
cord-006229-7yoilsho	4330	1	Pulmonary	pulmonary	JJ
cord-006229-7yoilsho	4330	2	inflammation	inflammation	NN
cord-006229-7yoilsho	4330	3	,	,	,
cord-006229-7yoilsho	4330	4	characterized	characterize	VBN
cord-006229-7yoilsho	4330	5	by	by	IN
cord-006229-7yoilsho	4330	6	liberation	liberation	NN
cord-006229-7yoilsho	4330	7	of	of	IN
cord-006229-7yoilsho	4330	8	cytokines	cytokine	NNS
cord-006229-7yoilsho	4330	9	,	,	,
cord-006229-7yoilsho	4330	10	chemokines	chemokine	NNS
cord-006229-7yoilsho	4330	11	and	and	CC
cord-006229-7yoilsho	4330	12	oedema	oedema	NN
cord-006229-7yoilsho	4330	13	formation	formation	NN
cord-006229-7yoilsho	4330	14	,	,	,
cord-006229-7yoilsho	4330	15	was	be	VBD
cord-006229-7yoilsho	4330	16	attenuated	attenuate	VBN
cord-006229-7yoilsho	4330	17	in	in	IN
cord-006229-7yoilsho	4330	18	Nrf2	Nrf2	NNP
cord-006229-7yoilsho	4330	19	-/mice	-/mice	''
cord-006229-7yoilsho	4330	20	.	.	.
cord-006229-7yoilsho	4331	1	In	in	IN
cord-006229-7yoilsho	4331	2	contrast	contrast	NN
cord-006229-7yoilsho	4331	3	,	,	,
cord-006229-7yoilsho	4331	4	HCl	HCl	NNP
cord-006229-7yoilsho	4331	5	pH=1.3	pH=1.3	NNP
cord-006229-7yoilsho	4331	6	caused	cause	VBD
cord-006229-7yoilsho	4331	7	more	more	JJR
cord-006229-7yoilsho	4331	8	severe	severe	JJ
cord-006229-7yoilsho	4331	9	lung	lung	NN
cord-006229-7yoilsho	4331	10	injury	injury	NN
cord-006229-7yoilsho	4332	1	(	(	-LRB-
cord-006229-7yoilsho	4332	2	pO	po	NN
cord-006229-7yoilsho	4332	3	2	2	CD
cord-006229-7yoilsho	4332	4	/FiO	/fio	CD
cord-006229-7yoilsho	4332	5	2	2	CD
cord-006229-7yoilsho	4332	6	~200mmHg	~200mmHg	NFP
cord-006229-7yoilsho	4332	7	)	)	-RRB-
cord-006229-7yoilsho	4332	8	with	with	IN
cord-006229-7yoilsho	4332	9	a	a	DT
cord-006229-7yoilsho	4332	10	steeper	steep	JJR
cord-006229-7yoilsho	4332	11	incline	incline	NN
cord-006229-7yoilsho	4332	12	in	in	IN
cord-006229-7yoilsho	4332	13	elastance	elastance	NN
cord-006229-7yoilsho	4332	14	and	and	CC
cord-006229-7yoilsho	4332	15	more	more	RBR
cord-006229-7yoilsho	4332	16	severe	severe	JJ
cord-006229-7yoilsho	4332	17	inflammation	inflammation	NN
cord-006229-7yoilsho	4332	18	in	in	IN
cord-006229-7yoilsho	4332	19	both	both	CC
cord-006229-7yoilsho	4332	20	WT	WT	NNP
cord-006229-7yoilsho	4332	21	and	and	CC
cord-006229-7yoilsho	4332	22	Nrf2	Nrf2	NNP
cord-006229-7yoilsho	4332	23	-/mice	-/mice	NNP
cord-006229-7yoilsho	4332	24	.	.	.
cord-006229-7yoilsho	4333	1	Conclusion	conclusion	NN
cord-006229-7yoilsho	4333	2	:	:	:
cord-006229-7yoilsho	4334	1	We	-PRON-	PRP
cord-006229-7yoilsho	4334	2	conclude	conclude	VBP
cord-006229-7yoilsho	4334	3	that	that	IN
cord-006229-7yoilsho	4334	4	the	the	DT
cord-006229-7yoilsho	4334	5	presence	presence	NN
cord-006229-7yoilsho	4334	6	of	of	IN
cord-006229-7yoilsho	4334	7	Nrf2	Nrf2	NNP
cord-006229-7yoilsho	4334	8	augments	augment	VBZ
cord-006229-7yoilsho	4334	9	mild	mild	JJ
cord-006229-7yoilsho	4334	10	acid	acid	NN
cord-006229-7yoilsho	4334	11	-	-	HYPH
cord-006229-7yoilsho	4334	12	induced	induce	VBN
cord-006229-7yoilsho	4334	13	lung	lung	NN
cord-006229-7yoilsho	4334	14	injury	injury	NN
cord-006229-7yoilsho	4334	15	,	,	,
cord-006229-7yoilsho	4334	16	but	but	CC
cord-006229-7yoilsho	4334	17	plays	play	VBZ
cord-006229-7yoilsho	4334	18	no	no	DT
cord-006229-7yoilsho	4334	19	role	role	NN
cord-006229-7yoilsho	4334	20	in	in	IN
cord-006229-7yoilsho	4334	21	more	more	RBR
cord-006229-7yoilsho	4334	22	severe	severe	JJ
cord-006229-7yoilsho	4334	23	injury	injury	NN
cord-006229-7yoilsho	4334	24	.	.	.
cord-006229-7yoilsho	4335	1	These	these	DT
cord-006229-7yoilsho	4335	2	discrepant	discrepant	JJ
cord-006229-7yoilsho	4335	3	results	result	NNS
cord-006229-7yoilsho	4335	4	will	will	MD
cord-006229-7yoilsho	4335	5	be	be	VB
cord-006229-7yoilsho	4335	6	elucidated	elucidate	VBN
cord-006229-7yoilsho	4335	7	in	in	IN
cord-006229-7yoilsho	4335	8	future	future	JJ
cord-006229-7yoilsho	4335	9	investigations	investigation	NNS
cord-006229-7yoilsho	4335	10	.	.	.
cord-006229-7yoilsho	4336	1	Uniklinik	Uniklinik	NNP
cord-006229-7yoilsho	4336	2	RWTH	RWTH	NNP
cord-006229-7yoilsho	4336	3	Aachen	Aachen	NNP
cord-006229-7yoilsho	4336	4	,	,	,
cord-006229-7yoilsho	4336	5	Institut	Institut	NNP
cord-006229-7yoilsho	4336	6	für	für	IN
cord-006229-7yoilsho	4336	7	Pharmakologie	Pharmakologie	NNP
cord-006229-7yoilsho	4337	1	und	und	NNP
cord-006229-7yoilsho	4337	2	Toxikologie	Toxikologie	NNP
cord-006229-7yoilsho	4337	3	,	,	,
cord-006229-7yoilsho	4337	4	Aachen	Aachen	NNP
cord-006229-7yoilsho	4337	5	,	,	,
cord-006229-7yoilsho	4337	6	Germany	Germany	NNP
cord-006229-7yoilsho	4337	7	2	2	CD
cord-006229-7yoilsho	4337	8	Fakultät	Fakultät	NNP
cord-006229-7yoilsho	4337	9	für	für	NNP
cord-006229-7yoilsho	4337	10	Maschinenwesen	Maschinenwesen	NNP
cord-006229-7yoilsho	4337	11	der	der	NNP
cord-006229-7yoilsho	4337	12	RWTH	RWTH	NNP
cord-006229-7yoilsho	4337	13	Aachen	Aachen	NNP
cord-006229-7yoilsho	4337	14	,	,	,
cord-006229-7yoilsho	4337	15	Werkzeugmaschinenlabor	Werkzeugmaschinenlabor	NNP
cord-006229-7yoilsho	4337	16	,	,	,
cord-006229-7yoilsho	4337	17	Aachen	Aachen	NNP
cord-006229-7yoilsho	4337	18	,	,	,
cord-006229-7yoilsho	4338	1	Germany	Germany	NNP
cord-006229-7yoilsho	4338	2	Rationale	Rationale	NNP
cord-006229-7yoilsho	4338	3	:	:	:
cord-006229-7yoilsho	4339	1	Reproducibility	reproducibility	NN
cord-006229-7yoilsho	4339	2	is	be	VBZ
cord-006229-7yoilsho	4339	3	key	key	JJ
cord-006229-7yoilsho	4339	4	to	to	IN
cord-006229-7yoilsho	4339	5	science	science	NN
cord-006229-7yoilsho	4339	6	.	.	.
cord-006229-7yoilsho	4340	1	In	in	IN
cord-006229-7yoilsho	4340	2	recent	recent	JJ
cord-006229-7yoilsho	4340	3	times	time	NNS
cord-006229-7yoilsho	4340	4	,	,	,
cord-006229-7yoilsho	4340	5	the	the	DT
cord-006229-7yoilsho	4340	6	reproducibility	reproducibility	NN
cord-006229-7yoilsho	4340	7	of	of	IN
cord-006229-7yoilsho	4340	8	biomedical	biomedical	JJ
cord-006229-7yoilsho	4340	9	research	research	NN
cord-006229-7yoilsho	4340	10	has	have	VBZ
cord-006229-7yoilsho	4340	11	been	be	VBN
cord-006229-7yoilsho	4340	12	questioned	question	VBN
cord-006229-7yoilsho	4340	13	increasingly	increasingly	RB
cord-006229-7yoilsho	4340	14	.	.	.
cord-006229-7yoilsho	4341	1	This	this	DT
cord-006229-7yoilsho	4341	2	reproducibility	reproducibility	NN
cord-006229-7yoilsho	4341	3	crisis	crisis	NN
cord-006229-7yoilsho	4341	4	also	also	RB
cord-006229-7yoilsho	4341	5	affects	affect	VBZ
cord-006229-7yoilsho	4341	6	complex	complex	JJ
cord-006229-7yoilsho	4341	7	animal	animal	NN
cord-006229-7yoilsho	4341	8	experiments	experiment	NNS
cord-006229-7yoilsho	4341	9	,	,	,
cord-006229-7yoilsho	4341	10	which	which	WDT
cord-006229-7yoilsho	4341	11	-if	-if	:
cord-006229-7yoilsho	4341	12	not	not	RB
cord-006229-7yoilsho	4341	13	reproducible	reproducible	JJ
cord-006229-7yoilsho	4341	14	-might	-might	:
cord-006229-7yoilsho	4341	15	also	also	RB
cord-006229-7yoilsho	4341	16	be	be	VB
cord-006229-7yoilsho	4341	17	regarded	regard	VBN
cord-006229-7yoilsho	4341	18	as	as	IN
cord-006229-7yoilsho	4341	19	unethical	unethical	JJ
cord-006229-7yoilsho	4341	20	and	and	CC
cord-006229-7yoilsho	4341	21	lose	lose	VB
cord-006229-7yoilsho	4341	22	public	public	JJ
cord-006229-7yoilsho	4341	23	acceptance	acceptance	NN
cord-006229-7yoilsho	4341	24	.	.	.
cord-006229-7yoilsho	4342	1	Part	part	NN
cord-006229-7yoilsho	4342	2	of	of	IN
cord-006229-7yoilsho	4342	3	the	the	DT
cord-006229-7yoilsho	4342	4	problem	problem	NN
cord-006229-7yoilsho	4342	5	is	be	VBZ
cord-006229-7yoilsho	4342	6	frequently	frequently	RB
cord-006229-7yoilsho	4342	7	that	that	IN
cord-006229-7yoilsho	4342	8	the	the	DT
cord-006229-7yoilsho	4342	9	provided	provide	VBN
cord-006229-7yoilsho	4342	10	documentation	documentation	NN
cord-006229-7yoilsho	4342	11	is	be	VBZ
cord-006229-7yoilsho	4342	12	not	not	RB
cord-006229-7yoilsho	4342	13	sufficient	sufficient	JJ
cord-006229-7yoilsho	4342	14	for	for	IN
cord-006229-7yoilsho	4342	15	reproduction	reproduction	NN
cord-006229-7yoilsho	4342	16	.	.	.
cord-006229-7yoilsho	4343	1	Therefore	therefore	RB
cord-006229-7yoilsho	4343	2	,	,	,
cord-006229-7yoilsho	4343	3	in	in	IN
cord-006229-7yoilsho	4343	4	this	this	DT
cord-006229-7yoilsho	4343	5	study	study	NN
cord-006229-7yoilsho	4343	6	we	-PRON-	PRP
cord-006229-7yoilsho	4343	7	analyzed	analyze	VBD
cord-006229-7yoilsho	4343	8	the	the	DT
cord-006229-7yoilsho	4343	9	potential	potential	NN
cord-006229-7yoilsho	4343	10	of	of	IN
cord-006229-7yoilsho	4343	11	conventional	conventional	JJ
cord-006229-7yoilsho	4343	12	quality	quality	NN
cord-006229-7yoilsho	4343	13	management	management	NN
cord-006229-7yoilsho	4343	14	tools	tool	NNS
cord-006229-7yoilsho	4343	15	-used	-use	VBN
cord-006229-7yoilsho	4343	16	as	as	IN
cord-006229-7yoilsho	4343	17	standard	standard	NN
cord-006229-7yoilsho	4343	18	in	in	IN
cord-006229-7yoilsho	4343	19	machine	machine	NN
cord-006229-7yoilsho	4343	20	production	production	NN
cord-006229-7yoilsho	4343	21	-as	-as	:
cord-006229-7yoilsho	4343	22	an	an	DT
cord-006229-7yoilsho	4343	23	approach	approach	NN
cord-006229-7yoilsho	4343	24	to	to	TO
cord-006229-7yoilsho	4343	25	improve	improve	VB
cord-006229-7yoilsho	4343	26	the	the	DT
cord-006229-7yoilsho	4343	27	documentation	documentation	NN
cord-006229-7yoilsho	4343	28	and	and	CC
cord-006229-7yoilsho	4343	29	ascertain	ascertain	VB
cord-006229-7yoilsho	4343	30	the	the	DT
cord-006229-7yoilsho	4343	31	quality	quality	NN
cord-006229-7yoilsho	4343	32	of	of	IN
cord-006229-7yoilsho	4343	33	complex	complex	JJ
cord-006229-7yoilsho	4343	34	animal	animal	NN
cord-006229-7yoilsho	4343	35	experiments	experiment	NNS
cord-006229-7yoilsho	4343	36	.	.	.
cord-006229-7yoilsho	4344	1	Methods	method	NNS
cord-006229-7yoilsho	4344	2	:	:	:
cord-006229-7yoilsho	4345	1	Quality	quality	NN
cord-006229-7yoilsho	4345	2	management	management	NN
cord-006229-7yoilsho	4345	3	tools	tool	NNS
cord-006229-7yoilsho	4345	4	were	be	VBD
cord-006229-7yoilsho	4345	5	transferred	transfer	VBN
cord-006229-7yoilsho	4345	6	to	to	IN
cord-006229-7yoilsho	4345	7	an	an	DT
cord-006229-7yoilsho	4345	8	experimental	experimental	JJ
cord-006229-7yoilsho	4345	9	animal	animal	NN
cord-006229-7yoilsho	4345	10	set	set	VBN
cord-006229-7yoilsho	4345	11	up	up	RP
cord-006229-7yoilsho	4345	12	-the	-the	DT
cord-006229-7yoilsho	4345	13	mouse	mouse	NN
cord-006229-7yoilsho	4345	14	intensive	intensive	JJ
cord-006229-7yoilsho	4345	15	care	care	NN
cord-006229-7yoilsho	4345	16	unit	unit	NN
cord-006229-7yoilsho	4345	17	(	(	-LRB-
cord-006229-7yoilsho	4345	18	MICU	MICU	NNP
cord-006229-7yoilsho	4345	19	)	)	-RRB-
cord-006229-7yoilsho	4346	1	-which	-which	.
cord-006229-7yoilsho	4347	1	we	-PRON-	PRP
cord-006229-7yoilsho	4347	2	use	use	VBP
cord-006229-7yoilsho	4347	3	for	for	IN
cord-006229-7yoilsho	4347	4	lung	lung	NN
cord-006229-7yoilsho	4347	5	injury	injury	NN
cord-006229-7yoilsho	4347	6	studies	study	NNS
cord-006229-7yoilsho	4347	7	.	.	.
cord-006229-7yoilsho	4348	1	The	the	DT
cord-006229-7yoilsho	4348	2	tools	tool	NNS
cord-006229-7yoilsho	4348	3	included	include	VBD
cord-006229-7yoilsho	4348	4	visualization	visualization	NN
cord-006229-7yoilsho	4348	5	of	of	IN
cord-006229-7yoilsho	4348	6	the	the	DT
cord-006229-7yoilsho	4348	7	experimental	experimental	JJ
cord-006229-7yoilsho	4348	8	set	set	NN
cord-006229-7yoilsho	4348	9	-	-	HYPH
cord-006229-7yoilsho	4348	10	up	up	NN
cord-006229-7yoilsho	4348	11	,	,	,
cord-006229-7yoilsho	4348	12	transfer	transfer	NN
cord-006229-7yoilsho	4348	13	of	of	IN
cord-006229-7yoilsho	4348	14	the	the	DT
cord-006229-7yoilsho	4348	15	experimental	experimental	JJ
cord-006229-7yoilsho	4348	16	procedures	procedure	NNS
cord-006229-7yoilsho	4348	17	to	to	IN
cord-006229-7yoilsho	4348	18	an	an	DT
cord-006229-7yoilsho	4348	19	event	event	NN
cord-006229-7yoilsho	4348	20	-	-	HYPH
cord-006229-7yoilsho	4348	21	driven	drive	VBN
cord-006229-7yoilsho	4348	22	process	process	NN
cord-006229-7yoilsho	4348	23	chain	chain	NN
cord-006229-7yoilsho	4348	24	(	(	-LRB-
cord-006229-7yoilsho	4348	25	EPC	EPC	NNP
cord-006229-7yoilsho	4348	26	)	)	-RRB-
cord-006229-7yoilsho	4348	27	and	and	CC
cord-006229-7yoilsho	4348	28	statistical	statistical	JJ
cord-006229-7yoilsho	4348	29	process	process	NN
cord-006229-7yoilsho	4348	30	control	control	NN
cord-006229-7yoilsho	4348	31	(	(	-LRB-
cord-006229-7yoilsho	4348	32	SPC	SPC	NNP
cord-006229-7yoilsho	4348	33	)	)	-RRB-
cord-006229-7yoilsho	4348	34	of	of	IN
cord-006229-7yoilsho	4348	35	all	all	DT
cord-006229-7yoilsho	4348	36	crucial	crucial	JJ
cord-006229-7yoilsho	4348	37	pulmonary	pulmonary	JJ
cord-006229-7yoilsho	4348	38	and	and	CC
cord-006229-7yoilsho	4348	39	cardiovascular	cardiovascular	JJ
cord-006229-7yoilsho	4348	40	parameters	parameter	NNS
cord-006229-7yoilsho	4348	41	.	.	.
cord-006229-7yoilsho	4349	1	Data	datum	NNS
cord-006229-7yoilsho	4349	2	from	from	IN
cord-006229-7yoilsho	4349	3	ventilator	ventilator	NN
cord-006229-7yoilsho	4349	4	-	-	HYPH
cord-006229-7yoilsho	4349	5	and	and	CC
cord-006229-7yoilsho	4349	6	acidinduced	acidinduced	NNP
cord-006229-7yoilsho	4349	7	lung	lung	NNP
cord-006229-7yoilsho	4349	8	injury	injury	NN
cord-006229-7yoilsho	4349	9	studies	study	NNS
cord-006229-7yoilsho	4349	10	acquired	acquire	VBD
cord-006229-7yoilsho	4349	11	in	in	IN
cord-006229-7yoilsho	4349	12	the	the	DT
cord-006229-7yoilsho	4349	13	MICU	MICU	NNP
cord-006229-7yoilsho	4349	14	were	be	VBD
cord-006229-7yoilsho	4349	15	analyzed	analyze	VBN
cord-006229-7yoilsho	4349	16	retrospectively	retrospectively	RB
cord-006229-7yoilsho	4349	17	.	.	.
cord-006229-7yoilsho	4350	1	Results	result	NNS
cord-006229-7yoilsho	4350	2	:	:	:
cord-006229-7yoilsho	4351	1	Schematic	schematic	JJ
cord-006229-7yoilsho	4351	2	visualization	visualization	NN
cord-006229-7yoilsho	4351	3	of	of	IN
cord-006229-7yoilsho	4351	4	the	the	DT
cord-006229-7yoilsho	4351	5	MICU	MICU	NNP
cord-006229-7yoilsho	4351	6	resulted	result	VBD
cord-006229-7yoilsho	4351	7	in	in	IN
cord-006229-7yoilsho	4351	8	a	a	DT
cord-006229-7yoilsho	4351	9	chart	chart	NN
cord-006229-7yoilsho	4351	10	comprising	comprise	VBG
cord-006229-7yoilsho	4351	11	medical	medical	JJ
cord-006229-7yoilsho	4351	12	components	component	NNS
cord-006229-7yoilsho	4351	13	,	,	,
cord-006229-7yoilsho	4351	14	hardware	hardware	NN
cord-006229-7yoilsho	4351	15	,	,	,
cord-006229-7yoilsho	4351	16	software	software	NN
cord-006229-7yoilsho	4351	17	and	and	CC
cord-006229-7yoilsho	4351	18	generated	generate	VBD
cord-006229-7yoilsho	4351	19	data	data	NN
cord-006229-7yoilsho	4351	20	types	type	NNS
cord-006229-7yoilsho	4351	21	.	.	.
cord-006229-7yoilsho	4352	1	The	the	DT
cord-006229-7yoilsho	4352	2	customized	customize	VBN
cord-006229-7yoilsho	4352	3	EPC	EPC	NNP
cord-006229-7yoilsho	4352	4	included	include	VBD
cord-006229-7yoilsho	4352	5	all	all	DT
cord-006229-7yoilsho	4352	6	important	important	JJ
cord-006229-7yoilsho	4352	7	activities	activity	NNS
cord-006229-7yoilsho	4352	8	and	and	CC
cord-006229-7yoilsho	4352	9	the	the	DT
cord-006229-7yoilsho	4352	10	resulting	result	VBG
cord-006229-7yoilsho	4352	11	events	event	NNS
cord-006229-7yoilsho	4352	12	for	for	IN
cord-006229-7yoilsho	4352	13	preparation	preparation	NN
cord-006229-7yoilsho	4352	14	of	of	IN
cord-006229-7yoilsho	4352	15	the	the	DT
cord-006229-7yoilsho	4352	16	mouse	mouse	NN
cord-006229-7yoilsho	4352	17	and	and	CC
cord-006229-7yoilsho	4352	18	the	the	DT
cord-006229-7yoilsho	4352	19	workplace	workplace	NN
cord-006229-7yoilsho	4352	20	,	,	,
cord-006229-7yoilsho	4352	21	the	the	DT
cord-006229-7yoilsho	4352	22	actual	actual	JJ
cord-006229-7yoilsho	4352	23	animal	animal	NN
cord-006229-7yoilsho	4352	24	ventilation	ventilation	NN
cord-006229-7yoilsho	4352	25	experiment	experiment	NN
cord-006229-7yoilsho	4352	26	and	and	CC
cord-006229-7yoilsho	4352	27	sample	sample	NN
cord-006229-7yoilsho	4352	28	-	-	HYPH
cord-006229-7yoilsho	4352	29	taking	taking	NN
cord-006229-7yoilsho	4352	30	.	.	.
cord-006229-7yoilsho	4353	1	In	in	IN
cord-006229-7yoilsho	4353	2	addition	addition	NN
cord-006229-7yoilsho	4353	3	,	,	,
cord-006229-7yoilsho	4353	4	checklists	checklist	NNS
cord-006229-7yoilsho	4353	5	were	be	VBD
cord-006229-7yoilsho	4353	6	provided	provide	VBN
cord-006229-7yoilsho	4353	7	for	for	IN
cord-006229-7yoilsho	4353	8	these	these	DT
cord-006229-7yoilsho	4353	9	activities	activity	NNS
cord-006229-7yoilsho	4353	10	and	and	CC
cord-006229-7yoilsho	4353	11	events	event	NNS
cord-006229-7yoilsho	4353	12	,	,	,
cord-006229-7yoilsho	4353	13	to	to	TO
cord-006229-7yoilsho	4353	14	ensure	ensure	VB
cord-006229-7yoilsho	4353	15	standardization	standardization	NN
cord-006229-7yoilsho	4353	16	of	of	IN
cord-006229-7yoilsho	4353	17	every	every	DT
cord-006229-7yoilsho	4353	18	work	work	NN
cord-006229-7yoilsho	4353	19	step	step	NN
cord-006229-7yoilsho	4353	20	.	.	.
cord-006229-7yoilsho	4354	1	Lung	lung	NN
cord-006229-7yoilsho	4354	2	impedance	impedance	NN
cord-006229-7yoilsho	4354	3	and	and	CC
cord-006229-7yoilsho	4354	4	cardiac	cardiac	JJ
cord-006229-7yoilsho	4354	5	functions	function	NNS
cord-006229-7yoilsho	4354	6	from	from	IN
cord-006229-7yoilsho	4354	7	ventilator	ventilator	NN
cord-006229-7yoilsho	4354	8	-	-	HYPH
cord-006229-7yoilsho	4354	9	and	and	CC
cord-006229-7yoilsho	4354	10	acid	acid	NN
cord-006229-7yoilsho	4354	11	-	-	HYPH
cord-006229-7yoilsho	4354	12	induced	induce	VBN
cord-006229-7yoilsho	4354	13	lung	lung	NN
cord-006229-7yoilsho	4354	14	injury	injury	NN
cord-006229-7yoilsho	4354	15	models	model	NNS
cord-006229-7yoilsho	4354	16	were	be	VBD
cord-006229-7yoilsho	4354	17	analyzed	analyze	VBN
cord-006229-7yoilsho	4354	18	by	by	IN
cord-006229-7yoilsho	4354	19	SPC	SPC	NNP
cord-006229-7yoilsho	4354	20	and	and	CC
cord-006229-7yoilsho	4354	21	correlated	correlate	VBD
cord-006229-7yoilsho	4354	22	with	with	IN
cord-006229-7yoilsho	4354	23	events	event	NNS
cord-006229-7yoilsho	4354	24	in	in	IN
cord-006229-7yoilsho	4354	25	the	the	DT
cord-006229-7yoilsho	4354	26	EPC	EPC	NNP
cord-006229-7yoilsho	4354	27	.	.	.
cord-006229-7yoilsho	4355	1	The	the	DT
cord-006229-7yoilsho	4355	2	SPC	SPC	NNP
cord-006229-7yoilsho	4355	3	proved	prove	VBD
cord-006229-7yoilsho	4355	4	to	to	TO
cord-006229-7yoilsho	4355	5	be	be	VB
cord-006229-7yoilsho	4355	6	suitable	suitable	JJ
cord-006229-7yoilsho	4355	7	to	to	TO
cord-006229-7yoilsho	4355	8	identify	identify	VB
cord-006229-7yoilsho	4355	9	outliers	outlier	NNS
cord-006229-7yoilsho	4355	10	,	,	,
cord-006229-7yoilsho	4355	11	predict	predict	VB
cord-006229-7yoilsho	4355	12	processes	process	NNS
cord-006229-7yoilsho	4355	13	and	and	CC
cord-006229-7yoilsho	4355	14	thereby	thereby	RB
cord-006229-7yoilsho	4355	15	validate	validate	VB
cord-006229-7yoilsho	4355	16	the	the	DT
cord-006229-7yoilsho	4355	17	lung	lung	NN
cord-006229-7yoilsho	4355	18	injury	injury	NN
cord-006229-7yoilsho	4355	19	models	model	NNS
cord-006229-7yoilsho	4355	20	.	.	.
cord-006229-7yoilsho	4356	1	Conclusions	conclusion	NNS
cord-006229-7yoilsho	4356	2	:	:	:
cord-006229-7yoilsho	4356	3	Conventional	conventional	JJ
cord-006229-7yoilsho	4356	4	quality	quality	NN
cord-006229-7yoilsho	4356	5	management	management	NN
cord-006229-7yoilsho	4356	6	tools	tool	NNS
cord-006229-7yoilsho	4356	7	were	be	VBD
cord-006229-7yoilsho	4356	8	successfully	successfully	RB
cord-006229-7yoilsho	4356	9	adapted	adapt	VBN
cord-006229-7yoilsho	4356	10	to	to	TO
cord-006229-7yoilsho	4356	11	analyze	analyze	VB
cord-006229-7yoilsho	4356	12	the	the	DT
cord-006229-7yoilsho	4356	13	quality	quality	NN
cord-006229-7yoilsho	4356	14	of	of	IN
cord-006229-7yoilsho	4356	15	lung	lung	NN
cord-006229-7yoilsho	4356	16	injury	injury	NN
cord-006229-7yoilsho	4356	17	experiments	experiment	NNS
cord-006229-7yoilsho	4356	18	in	in	IN
cord-006229-7yoilsho	4356	19	the	the	DT
cord-006229-7yoilsho	4356	20	MICU	MICU	NNP
cord-006229-7yoilsho	4356	21	.	.	.
cord-006229-7yoilsho	4357	1	We	-PRON-	PRP
cord-006229-7yoilsho	4357	2	suggest	suggest	VBP
cord-006229-7yoilsho	4357	3	that	that	IN
cord-006229-7yoilsho	4357	4	this	this	DT
cord-006229-7yoilsho	4357	5	new	new	JJ
cord-006229-7yoilsho	4357	6	approach	approach	NN
cord-006229-7yoilsho	4357	7	is	be	VBZ
cord-006229-7yoilsho	4357	8	suitable	suitable	JJ
cord-006229-7yoilsho	4357	9	to	to	TO
cord-006229-7yoilsho	4357	10	standardize	standardize	VB
cord-006229-7yoilsho	4357	11	animal	animal	NN
cord-006229-7yoilsho	4357	12	testing	testing	NN
cord-006229-7yoilsho	4357	13	procedures	procedure	NNS
cord-006229-7yoilsho	4357	14	and	and	CC
cord-006229-7yoilsho	4357	15	increase	increase	VB
cord-006229-7yoilsho	4357	16	the	the	DT
cord-006229-7yoilsho	4357	17	reproducibility	reproducibility	NN
cord-006229-7yoilsho	4357	18	of	of	IN
cord-006229-7yoilsho	4357	19	animal	animal	NN
cord-006229-7yoilsho	4357	20	studies	study	NNS
cord-006229-7yoilsho	4357	21	.	.	.
cord-006229-7yoilsho	4358	1	Background	background	NN
cord-006229-7yoilsho	4358	2	:	:	:
cord-006229-7yoilsho	4359	1	A	a	DT
cord-006229-7yoilsho	4359	2	dysfunctional	dysfunctional	JJ
cord-006229-7yoilsho	4359	3	endothelial	endothelial	NN
cord-006229-7yoilsho	4360	1	L	l	NN
cord-006229-7yoilsho	4360	2	-	-	HYPH
cord-006229-7yoilsho	4360	3	arginine	arginine	NN
cord-006229-7yoilsho	4360	4	-	-	HYPH
cord-006229-7yoilsho	4360	5	nitric	nitric	NN
cord-006229-7yoilsho	4360	6	oxide	oxide	NN
cord-006229-7yoilsho	4361	1	(	(	-LRB-
cord-006229-7yoilsho	4361	2	NO	no	DT
cord-006229-7yoilsho	4361	3	)	)	-RRB-
cord-006229-7yoilsho	4361	4	pathway	pathway	NN
cord-006229-7yoilsho	4361	5	is	be	VBZ
cord-006229-7yoilsho	4361	6	a	a	DT
cord-006229-7yoilsho	4361	7	key	key	JJ
cord-006229-7yoilsho	4361	8	pathomechanism	pathomechanism	NN
cord-006229-7yoilsho	4361	9	of	of	IN
cord-006229-7yoilsho	4361	10	idiopathic	idiopathic	JJ
cord-006229-7yoilsho	4361	11	pulmonary	pulmonary	JJ
cord-006229-7yoilsho	4361	12	arterial	arterial	JJ
cord-006229-7yoilsho	4361	13	hypertension	hypertension	NN
cord-006229-7yoilsho	4361	14	(	(	-LRB-
cord-006229-7yoilsho	4361	15	IPAH	IPAH	NNP
cord-006229-7yoilsho	4361	16	)	)	-RRB-
cord-006229-7yoilsho	4361	17	that	that	WDT
cord-006229-7yoilsho	4361	18	can	can	MD
cord-006229-7yoilsho	4361	19	be	be	VB
cord-006229-7yoilsho	4361	20	provoked	provoke	VBN
cord-006229-7yoilsho	4361	21	by	by	IN
cord-006229-7yoilsho	4361	22	hypoxia	hypoxia	NN
cord-006229-7yoilsho	4361	23	in	in	IN
cord-006229-7yoilsho	4361	24	cell	cell	NN
cord-006229-7yoilsho	4361	25	culture	culture	NN
cord-006229-7yoilsho	4361	26	models	model	NNS
cord-006229-7yoilsho	4361	27	[	[	-LRB-
cord-006229-7yoilsho	4361	28	1	1	CD
cord-006229-7yoilsho	4361	29	]	]	-RRB-
cord-006229-7yoilsho	4361	30	[	[	-LRB-
cord-006229-7yoilsho	4361	31	2	2	CD
cord-006229-7yoilsho	4361	32	]	]	-RRB-
cord-006229-7yoilsho	4361	33	[	[	-LRB-
cord-006229-7yoilsho	4361	34	3	3	CD
cord-006229-7yoilsho	4361	35	]	]	-RRB-
cord-006229-7yoilsho	4361	36	[	[	-LRB-
cord-006229-7yoilsho	4361	37	4	4	CD
cord-006229-7yoilsho	4361	38	]	]	-RRB-
cord-006229-7yoilsho	4361	39	.	.	.
cord-006229-7yoilsho	4362	1	The	the	DT
cord-006229-7yoilsho	4362	2	small	small	JJ
cord-006229-7yoilsho	4362	3	peptide	peptide	NN
cord-006229-7yoilsho	4362	4	apelin	apelin	NN
cord-006229-7yoilsho	4362	5	is	be	VBZ
cord-006229-7yoilsho	4362	6	involved	involve	VBN
cord-006229-7yoilsho	4362	7	in	in	IN
cord-006229-7yoilsho	4362	8	the	the	DT
cord-006229-7yoilsho	4362	9	maintenance	maintenance	NN
cord-006229-7yoilsho	4362	10	of	of	IN
cord-006229-7yoilsho	4362	11	pulmonary	pulmonary	JJ
cord-006229-7yoilsho	4362	12	vascular	vascular	JJ
cord-006229-7yoilsho	4362	13	homeostasis	homeostasis	NN
cord-006229-7yoilsho	4362	14	and	and	CC
cord-006229-7yoilsho	4362	15	angiogenesis	angiogenesis	NN
cord-006229-7yoilsho	4362	16	although	although	IN
cord-006229-7yoilsho	4362	17	its	-PRON-	PRP$
cord-006229-7yoilsho	4362	18	precise	precise	JJ
cord-006229-7yoilsho	4362	19	mechanism	mechanism	NN
cord-006229-7yoilsho	4362	20	of	of	IN
cord-006229-7yoilsho	4362	21	action	action	NN
cord-006229-7yoilsho	4362	22	is	be	VBZ
cord-006229-7yoilsho	4362	23	still	still	RB
cord-006229-7yoilsho	4362	24	unclear	unclear	JJ
cord-006229-7yoilsho	4362	25	[	[	-LRB-
cord-006229-7yoilsho	4362	26	5	5	CD
cord-006229-7yoilsho	4362	27	]	]	-RRB-
cord-006229-7yoilsho	4362	28	.	.	.
cord-006229-7yoilsho	4363	1	Asymmetric	asymmetric	JJ
cord-006229-7yoilsho	4363	2	dimethylarginine	dimethylarginine	NN
cord-006229-7yoilsho	4363	3	(	(	-LRB-
cord-006229-7yoilsho	4363	4	ADMA	ADMA	NNP
cord-006229-7yoilsho	4363	5	)	)	-RRB-
cord-006229-7yoilsho	4363	6	is	be	VBZ
cord-006229-7yoilsho	4363	7	known	know	VBN
cord-006229-7yoilsho	4363	8	to	to	TO
cord-006229-7yoilsho	4363	9	be	be	VB
cord-006229-7yoilsho	4363	10	an	an	DT
cord-006229-7yoilsho	4363	11	endogenous	endogenous	JJ
cord-006229-7yoilsho	4363	12	inhibitor	inhibitor	NN
cord-006229-7yoilsho	4363	13	of	of	IN
cord-006229-7yoilsho	4363	14	endothelial	endothelial	JJ
cord-006229-7yoilsho	4363	15	NO	no	DT
cord-006229-7yoilsho	4363	16	synthase	synthase	NN
cord-006229-7yoilsho	4363	17	and	and	CC
cord-006229-7yoilsho	4363	18	is	be	VBZ
cord-006229-7yoilsho	4363	19	associated	associate	VBN
cord-006229-7yoilsho	4363	20	with	with	IN
cord-006229-7yoilsho	4363	21	several	several	JJ
cord-006229-7yoilsho	4363	22	cardiovascular	cardiovascular	JJ
cord-006229-7yoilsho	4363	23	diseases	disease	NNS
cord-006229-7yoilsho	4363	24	[	[	-LRB-
cord-006229-7yoilsho	4363	25	6	6	CD
cord-006229-7yoilsho	4363	26	]	]	-RRB-
cord-006229-7yoilsho	4363	27	.	.	.
cord-006229-7yoilsho	4364	1	ADMA	ADMA	NNP
cord-006229-7yoilsho	4364	2	is	be	VBZ
cord-006229-7yoilsho	4364	3	degraded	degrade	VBN
cord-006229-7yoilsho	4364	4	by	by	IN
cord-006229-7yoilsho	4364	5	dimethylarginine	dimethylarginine	JJ
cord-006229-7yoilsho	4364	6	dimethylaminohydrolase	dimethylaminohydrolase	NNP
cord-006229-7yoilsho	4364	7	1	1	CD
cord-006229-7yoilsho	4364	8	and	and	CC
cord-006229-7yoilsho	4364	9	2	2	CD
cord-006229-7yoilsho	4365	1	(	(	-LRB-
cord-006229-7yoilsho	4365	2	DDAH	DDAH	NNP
cord-006229-7yoilsho	4365	3	)	)	-RRB-
cord-006229-7yoilsho	4365	4	enzymes	enzyme	NNS
cord-006229-7yoilsho	4365	5	[	[	-LRB-
cord-006229-7yoilsho	4365	6	7	7	CD
cord-006229-7yoilsho	4365	7	]	]	-RRB-
cord-006229-7yoilsho	4365	8	.	.	.
cord-006229-7yoilsho	4366	1	Objective	objective	NN
cord-006229-7yoilsho	4366	2	:	:	:
cord-006229-7yoilsho	4367	1	To	to	TO
cord-006229-7yoilsho	4367	2	determine	determine	VB
cord-006229-7yoilsho	4367	3	the	the	DT
cord-006229-7yoilsho	4367	4	effect	effect	NN
cord-006229-7yoilsho	4367	5	of	of	IN
cord-006229-7yoilsho	4367	6	apelin	apelin	NN
cord-006229-7yoilsho	4367	7	on	on	IN
cord-006229-7yoilsho	4367	8	the	the	DT
cord-006229-7yoilsho	4367	9	L	l	NN
cord-006229-7yoilsho	4367	10	-	-	HYPH
cord-006229-7yoilsho	4367	11	arginine	arginine	NN
cord-006229-7yoilsho	4367	12	/	/	,
cord-006229-7yoilsho	4367	13	NO	no	DT
cord-006229-7yoilsho	4367	14	pathway	pathway	NN
cord-006229-7yoilsho	4367	15	in	in	IN
cord-006229-7yoilsho	4367	16	human	human	JJ
cord-006229-7yoilsho	4367	17	pulmonary	pulmonary	JJ
cord-006229-7yoilsho	4367	18	microvascular	microvascular	JJ
cord-006229-7yoilsho	4367	19	endothelial	endothelial	JJ
cord-006229-7yoilsho	4367	20	cells	cell	NNS
cord-006229-7yoilsho	4367	21	(	(	-LRB-
cord-006229-7yoilsho	4367	22	HPMECs	hpmec	NNS
cord-006229-7yoilsho	4367	23	)	)	-RRB-
cord-006229-7yoilsho	4367	24	.	.	.
cord-006229-7yoilsho	4368	1	Methods	method	NNS
cord-006229-7yoilsho	4368	2	:	:	:
cord-006229-7yoilsho	4369	1	HPMECs	hpmec	NNS
cord-006229-7yoilsho	4369	2	were	be	VBD
cord-006229-7yoilsho	4369	3	cultured	culture	VBN
cord-006229-7yoilsho	4369	4	under	under	IN
cord-006229-7yoilsho	4369	5	normoxic	normoxic	JJ
cord-006229-7yoilsho	4369	6	and	and	CC
cord-006229-7yoilsho	4369	7	PH	ph	NN
cord-006229-7yoilsho	4369	8	-	-	HYPH
cord-006229-7yoilsho	4369	9	related	relate	VBN
cord-006229-7yoilsho	4369	10	hypoxic	hypoxic	JJ
cord-006229-7yoilsho	4369	11	conditions	condition	NNS
cord-006229-7yoilsho	4369	12	and	and	CC
cord-006229-7yoilsho	4369	13	treated	treat	VBN
cord-006229-7yoilsho	4369	14	with	with	IN
cord-006229-7yoilsho	4369	15	apelin	apelin	NNP
cord-006229-7yoilsho	4369	16	.	.	.
cord-006229-7yoilsho	4370	1	The	the	DT
cord-006229-7yoilsho	4370	2	expression	expression	NN
cord-006229-7yoilsho	4370	3	of	of	IN
cord-006229-7yoilsho	4370	4	regulators	regulator	NNS
cord-006229-7yoilsho	4370	5	of	of	IN
cord-006229-7yoilsho	4370	6	the	the	DT
cord-006229-7yoilsho	4370	7	L	l	NN
cord-006229-7yoilsho	4370	8	-	-	HYPH
cord-006229-7yoilsho	4370	9	arginine	arginine	NN
cord-006229-7yoilsho	4370	10	/	/	,
cord-006229-7yoilsho	4370	11	NO	no	DT
cord-006229-7yoilsho	4370	12	pathway	pathway	NN
cord-006229-7yoilsho	4370	13	were	be	VBD
cord-006229-7yoilsho	4370	14	analysed	analyse	VBN
cord-006229-7yoilsho	4370	15	using	use	VBG
cord-006229-7yoilsho	4370	16	real	real	JJ
cord-006229-7yoilsho	4370	17	-	-	HYPH
cord-006229-7yoilsho	4370	18	time	time	NN
cord-006229-7yoilsho	4370	19	PCR	PCR	NNP
cord-006229-7yoilsho	4370	20	.	.	.
cord-006229-7yoilsho	4371	1	The	the	DT
cord-006229-7yoilsho	4371	2	effect	effect	NN
cord-006229-7yoilsho	4371	3	of	of	IN
cord-006229-7yoilsho	4371	4	apelin	apelin	NN
cord-006229-7yoilsho	4371	5	on	on	IN
cord-006229-7yoilsho	4371	6	the	the	DT
cord-006229-7yoilsho	4371	7	phosphoinositide-3	phosphoinositide-3	NNP
cord-006229-7yoilsho	4371	8	kinase	kinase	NN
cord-006229-7yoilsho	4371	9	(	(	-LRB-
cord-006229-7yoilsho	4371	10	PI3K)/Akt	PI3K)/Akt	NNP
cord-006229-7yoilsho	4371	11	signalling	signal	VBG
cord-006229-7yoilsho	4371	12	pathway	pathway	NN
cord-006229-7yoilsho	4371	13	was	be	VBD
cord-006229-7yoilsho	4371	14	determined	determine	VBN
cord-006229-7yoilsho	4371	15	using	use	VBG
cord-006229-7yoilsho	4371	16	immunoassays	immunoassays	NNP
cord-006229-7yoilsho	4371	17	and	and	CC
cord-006229-7yoilsho	4371	18	specific	specific	JJ
cord-006229-7yoilsho	4371	19	inhibitors[LH1	inhibitors[LH1	''
cord-006229-7yoilsho	4371	20	]	]	-RRB-
cord-006229-7yoilsho	4371	21	.	.	.
cord-006229-7yoilsho	4372	1	Apelin	Apelin	NNP
cord-006229-7yoilsho	4372	2	and	and	CC
cord-006229-7yoilsho	4372	3	ADMA	ADMA	NNP
cord-006229-7yoilsho	4372	4	concentrations	concentration	NNS
cord-006229-7yoilsho	4372	5	were	be	VBD
cord-006229-7yoilsho	4372	6	measured	measure	VBN
cord-006229-7yoilsho	4372	7	in	in	IN
cord-006229-7yoilsho	4372	8	cell	cell	NN
cord-006229-7yoilsho	4372	9	culture	culture	NN
cord-006229-7yoilsho	4372	10	supernatants	supernatant	NNS
cord-006229-7yoilsho	4372	11	using	use	VBG
cord-006229-7yoilsho	4372	12	an	an	DT
cord-006229-7yoilsho	4372	13	enzyme	enzyme	NN
cord-006229-7yoilsho	4372	14	-	-	HYPH
cord-006229-7yoilsho	4372	15	linked	link	VBN
cord-006229-7yoilsho	4372	16	immunosorbent	immunosorbent	JJ
cord-006229-7yoilsho	4372	17	assay	assay	NN
cord-006229-7yoilsho	4372	18	and	and	CC
cord-006229-7yoilsho	4372	19	a	a	DT
cord-006229-7yoilsho	4372	20	liquid	liquid	JJ
cord-006229-7yoilsho	4372	21	chromatography	chromatography	NN
cord-006229-7yoilsho	4372	22	-	-	HYPH
cord-006229-7yoilsho	4372	23	tandem	tandem	NN
cord-006229-7yoilsho	4372	24	mass	mass	NN
cord-006229-7yoilsho	4372	25	spectrometry	spectrometry	NN
cord-006229-7yoilsho	4372	26	assay	assay	NN
cord-006229-7yoilsho	4372	27	.	.	.
cord-006229-7yoilsho	4373	1	Results	result	NNS
cord-006229-7yoilsho	4373	2	:	:	:
cord-006229-7yoilsho	4374	1	Treatment	treatment	NN
cord-006229-7yoilsho	4374	2	with	with	IN
cord-006229-7yoilsho	4374	3	Apelin	Apelin	NNP
cord-006229-7yoilsho	4374	4	resulted	result	VBD
cord-006229-7yoilsho	4374	5	in	in	IN
cord-006229-7yoilsho	4374	6	a	a	DT
cord-006229-7yoilsho	4374	7	reduced	reduce	VBN
cord-006229-7yoilsho	4374	8	expression	expression	NN
cord-006229-7yoilsho	4374	9	of	of	IN
cord-006229-7yoilsho	4374	10	the	the	DT
cord-006229-7yoilsho	4374	11	apelin	apelin	NNP
cord-006229-7yoilsho	4374	12	receptor	receptor	NN
cord-006229-7yoilsho	4374	13	(	(	-LRB-
cord-006229-7yoilsho	4374	14	AplnR	AplnR	NNP
cord-006229-7yoilsho	4374	15	)	)	-RRB-
cord-006229-7yoilsho	4374	16	on	on	IN
cord-006229-7yoilsho	4374	17	HPMECs	hpmec	NNS
cord-006229-7yoilsho	4374	18	suggesting	suggest	VBG
cord-006229-7yoilsho	4374	19	a	a	DT
cord-006229-7yoilsho	4374	20	negative	negative	JJ
cord-006229-7yoilsho	4374	21	feedback	feedback	NN
cord-006229-7yoilsho	4374	22	mechanism	mechanism	NN
cord-006229-7yoilsho	4374	23	.	.	.
cord-006229-7yoilsho	4375	1	Apelin	Apelin	NNP
cord-006229-7yoilsho	4375	2	directly	directly	RB
cord-006229-7yoilsho	4375	3	influenced	influence	VBD
cord-006229-7yoilsho	4375	4	the	the	DT
cord-006229-7yoilsho	4375	5	L	l	NN
cord-006229-7yoilsho	4375	6	-	-	HYPH
cord-006229-7yoilsho	4375	7	arginine	arginine	NN
cord-006229-7yoilsho	4375	8	/	/	,
cord-006229-7yoilsho	4375	9	NO	no	DT
cord-006229-7yoilsho	4375	10	pathway	pathway	NN
cord-006229-7yoilsho	4375	11	by	by	IN
cord-006229-7yoilsho	4375	12	increasing	increase	VBG
cord-006229-7yoilsho	4375	13	the	the	DT
cord-006229-7yoilsho	4375	14	expression	expression	NN
cord-006229-7yoilsho	4375	15	of	of	IN
cord-006229-7yoilsho	4375	16	DDAH1	ddah1	NN
cord-006229-7yoilsho	4375	17	and	and	CC
cord-006229-7yoilsho	4375	18	DDAH2	ddah2	NN
cord-006229-7yoilsho	4375	19	enzymes	enzyme	NNS
cord-006229-7yoilsho	4375	20	.	.	.
cord-006229-7yoilsho	4376	1	Thus	thus	RB
cord-006229-7yoilsho	4376	2	,	,	,
cord-006229-7yoilsho	4376	3	the	the	DT
cord-006229-7yoilsho	4376	4	concentration	concentration	NN
cord-006229-7yoilsho	4376	5	of	of	IN
cord-006229-7yoilsho	4376	6	ADMA	ADMA	NNP
cord-006229-7yoilsho	4376	7	was	be	VBD
cord-006229-7yoilsho	4376	8	decreased	decrease	VBN
cord-006229-7yoilsho	4376	9	in	in	IN
cord-006229-7yoilsho	4376	10	HPMECs	hpmec	NNS
cord-006229-7yoilsho	4376	11	supernatant	supernatant	JJ
cord-006229-7yoilsho	4376	12	following	follow	VBG
cord-006229-7yoilsho	4376	13	treatment	treatment	NN
cord-006229-7yoilsho	4376	14	with	with	IN
cord-006229-7yoilsho	4376	15	apelin	apelin	NNP
cord-006229-7yoilsho	4376	16	.	.	.
cord-006229-7yoilsho	4377	1	The	the	DT
cord-006229-7yoilsho	4377	2	effect	effect	NN
cord-006229-7yoilsho	4377	3	of	of	IN
cord-006229-7yoilsho	4377	4	apelin	apelin	NN
cord-006229-7yoilsho	4377	5	could	could	MD
cord-006229-7yoilsho	4377	6	be	be	VB
cord-006229-7yoilsho	4377	7	abrogated	abrogate	VBN
cord-006229-7yoilsho	4377	8	by	by	IN
cord-006229-7yoilsho	4377	9	modulation	modulation	NN
cord-006229-7yoilsho	4377	10	of	of	IN
cord-006229-7yoilsho	4377	11	the	the	DT
cord-006229-7yoilsho	4377	12	PI3K	PI3K	NNP
cord-006229-7yoilsho	4377	13	/	/	SYM
cord-006229-7yoilsho	4377	14	Akt	Akt	NNP
cord-006229-7yoilsho	4377	15	pathway	pathway	NN
cord-006229-7yoilsho	4377	16	.	.	.
cord-006229-7yoilsho	4378	1	Conclusion	conclusion	NN
cord-006229-7yoilsho	4378	2	:	:	:
cord-006229-7yoilsho	4379	1	Apelin	Apelin	NNP
cord-006229-7yoilsho	4379	2	modulates	modulate	VBZ
cord-006229-7yoilsho	4379	3	the	the	DT
cord-006229-7yoilsho	4379	4	L	l	NN
cord-006229-7yoilsho	4379	5	-	-	HYPH
cord-006229-7yoilsho	4379	6	arginine	arginine	NN
cord-006229-7yoilsho	4379	7	/	/	,
cord-006229-7yoilsho	4379	8	NO	no	DT
cord-006229-7yoilsho	4379	9	pathway	pathway	NN
cord-006229-7yoilsho	4379	10	and	and	CC
cord-006229-7yoilsho	4379	11	mediates	mediate	VBZ
cord-006229-7yoilsho	4379	12	enhanced	enhance	VBN
cord-006229-7yoilsho	4379	13	degradation	degradation	NN
cord-006229-7yoilsho	4379	14	of	of	IN
cord-006229-7yoilsho	4379	15	ADMA	ADMA	NNP
cord-006229-7yoilsho	4379	16	via	via	IN
cord-006229-7yoilsho	4379	17	an	an	DT
cord-006229-7yoilsho	4379	18	upregulated	upregulated	JJ
cord-006229-7yoilsho	4379	19	expression	expression	NN
cord-006229-7yoilsho	4379	20	of	of	IN
cord-006229-7yoilsho	4379	21	DDAH	DDAH	NNP
cord-006229-7yoilsho	4379	22	1	1	CD
cord-006229-7yoilsho	4379	23	and	and	CC
cord-006229-7yoilsho	4379	24	2	2	CD
cord-006229-7yoilsho	4379	25	enzymes	enzyme	NNS
cord-006229-7yoilsho	4379	26	.	.	.
cord-006229-7yoilsho	4380	1	The	the	DT
cord-006229-7yoilsho	4380	2	PI3K	PI3K	NNP
cord-006229-7yoilsho	4380	3	/	/	SYM
cord-006229-7yoilsho	4380	4	Akt	Akt	NNP
cord-006229-7yoilsho	4380	5	pathway	pathway	NN
cord-006229-7yoilsho	4380	6	might	may	MD
cord-006229-7yoilsho	4380	7	play	play	VB
cord-006229-7yoilsho	4380	8	a	a	DT
cord-006229-7yoilsho	4380	9	decisive	decisive	JJ
cord-006229-7yoilsho	4380	10	role	role	NN
cord-006229-7yoilsho	4380	11	in	in	IN
cord-006229-7yoilsho	4380	12	regulation	regulation	NN
cord-006229-7yoilsho	4380	13	of	of	IN
cord-006229-7yoilsho	4380	14	the	the	DT
cord-006229-7yoilsho	4380	15	effect	effect	NN
cord-006229-7yoilsho	4380	16	of	of	IN
cord-006229-7yoilsho	4380	17	aplein	aplein	NNP
cord-006229-7yoilsho	4380	18	.	.	.
cord-006229-7yoilsho	4381	1	An	an	DT
cord-006229-7yoilsho	4381	2	Apelin	Apelin	NNP
cord-006229-7yoilsho	4381	3	receptor	receptor	NN
cord-006229-7yoilsho	4381	4	agonist	agonist	NN
cord-006229-7yoilsho	4381	5	could	could	MD
cord-006229-7yoilsho	4381	6	be	be	VB
cord-006229-7yoilsho	4381	7	a	a	DT
cord-006229-7yoilsho	4381	8	novel	novel	JJ
cord-006229-7yoilsho	4381	9	and	and	CC
cord-006229-7yoilsho	4381	10	promising	promising	JJ
cord-006229-7yoilsho	4381	11	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	4381	12	option	option	NN
cord-006229-7yoilsho	4381	13	for	for	IN
cord-006229-7yoilsho	4381	14	IPAH	IPAH	NNP
cord-006229-7yoilsho	4381	15	treatment	treatment	NN
cord-006229-7yoilsho	4381	16	.	.	.
cord-006229-7yoilsho	4382	1	Background	background	NN
cord-006229-7yoilsho	4382	2	and	and	CC
cord-006229-7yoilsho	4382	3	purpose	purpose	NN
cord-006229-7yoilsho	4382	4	:	:	:
cord-006229-7yoilsho	4382	5	There	there	EX
cord-006229-7yoilsho	4382	6	is	be	VBZ
cord-006229-7yoilsho	4382	7	presently	presently	RB
cord-006229-7yoilsho	4382	8	no	no	DT
cord-006229-7yoilsho	4382	9	proven	prove	VBN
cord-006229-7yoilsho	4382	10	pharmacological	pharmacological	JJ
cord-006229-7yoilsho	4382	11	therapy	therapy	NN
cord-006229-7yoilsho	4382	12	for	for	IN
cord-006229-7yoilsho	4382	13	the	the	DT
cord-006229-7yoilsho	4382	14	Acute	Acute	NNP
cord-006229-7yoilsho	4382	15	Respiratory	Respiratory	NNP
cord-006229-7yoilsho	4382	16	Distress	Distress	NNP
cord-006229-7yoilsho	4382	17	Syndrome	Syndrome	NNP
cord-006229-7yoilsho	4382	18	(	(	-LRB-
cord-006229-7yoilsho	4382	19	ARDS	ARDS	NNP
cord-006229-7yoilsho	4382	20	)	)	-RRB-
cord-006229-7yoilsho	4382	21	.	.	.
cord-006229-7yoilsho	4383	1	Recently	recently	RB
cord-006229-7yoilsho	4383	2	,	,	,
cord-006229-7yoilsho	4383	3	we	-PRON-	PRP
cord-006229-7yoilsho	4383	4	and	and	CC
cord-006229-7yoilsho	4383	5	others	other	NNS
cord-006229-7yoilsho	4383	6	discovered	discover	VBD
cord-006229-7yoilsho	4383	7	that	that	IN
cord-006229-7yoilsho	4383	8	the	the	DT
cord-006229-7yoilsho	4383	9	heptapeptide	heptapeptide	NN
cord-006229-7yoilsho	4383	10	angiotensin	angiotensin	NN
cord-006229-7yoilsho	4383	11	(	(	-LRB-
cord-006229-7yoilsho	4383	12	Ang)-(1	Ang)-(1	NNP
cord-006229-7yoilsho	4383	13	-	-	HYPH
cord-006229-7yoilsho	4383	14	7	7	CD
cord-006229-7yoilsho	4383	15	)	)	-RRB-
cord-006229-7yoilsho	4383	16	shows	show	VBZ
cord-006229-7yoilsho	4383	17	significant	significant	JJ
cord-006229-7yoilsho	4383	18	beneficial	beneficial	JJ
cord-006229-7yoilsho	4383	19	effects	effect	NNS
cord-006229-7yoilsho	4383	20	in	in	IN
cord-006229-7yoilsho	4383	21	preclinical	preclinical	JJ
cord-006229-7yoilsho	4383	22	models	model	NNS
cord-006229-7yoilsho	4383	23	of	of	IN
cord-006229-7yoilsho	4383	24	acute	acute	JJ
cord-006229-7yoilsho	4383	25	lung	lung	NN
cord-006229-7yoilsho	4383	26	injury	injury	NN
cord-006229-7yoilsho	4383	27	(	(	-LRB-
cord-006229-7yoilsho	4383	28	ALI	ALI	NNP
cord-006229-7yoilsho	4383	29	)	)	-RRB-
cord-006229-7yoilsho	4383	30	.	.	.
cord-006229-7yoilsho	4384	1	Here	here	RB
cord-006229-7yoilsho	4384	2	,	,	,
cord-006229-7yoilsho	4384	3	we	-PRON-	PRP
cord-006229-7yoilsho	4384	4	aimed	aim	VBD
cord-006229-7yoilsho	4384	5	to	to	TO
cord-006229-7yoilsho	4384	6	identify	identify	VB
cord-006229-7yoilsho	4384	7	the	the	DT
cord-006229-7yoilsho	4384	8	best	good	JJS
cord-006229-7yoilsho	4384	9	time	time	NN
cord-006229-7yoilsho	4384	10	window	window	NN
cord-006229-7yoilsho	4384	11	for	for	IN
cord-006229-7yoilsho	4384	12	Ang-(1	Ang-(1	NNP
cord-006229-7yoilsho	4384	13	-	-	HYPH
cord-006229-7yoilsho	4384	14	7	7	CD
cord-006229-7yoilsho	4384	15	)	)	-RRB-
cord-006229-7yoilsho	4384	16	administration	administration	NN
cord-006229-7yoilsho	4384	17	to	to	TO
cord-006229-7yoilsho	4384	18	protect	protect	VB
cord-006229-7yoilsho	4384	19	rats	rat	NNS
cord-006229-7yoilsho	4384	20	from	from	IN
cord-006229-7yoilsho	4384	21	oleic	oleic	JJ
cord-006229-7yoilsho	4384	22	acid	acid	NN
cord-006229-7yoilsho	4384	23	(	(	-LRB-
cord-006229-7yoilsho	4384	24	OA	OA	NNP
cord-006229-7yoilsho	4384	25	)	)	-RRB-
cord-006229-7yoilsho	4384	26	induced	induce	VBD
cord-006229-7yoilsho	4384	27	ALI	ALI	NNP
cord-006229-7yoilsho	4384	28	.	.	.
cord-006229-7yoilsho	4385	1	Experimental	experimental	JJ
cord-006229-7yoilsho	4385	2	approach	approach	NN
cord-006229-7yoilsho	4385	3	:	:	:
cord-006229-7yoilsho	4385	4	The	the	DT
cord-006229-7yoilsho	4385	5	effects	effect	NNS
cord-006229-7yoilsho	4385	6	of	of	IN
cord-006229-7yoilsho	4385	7	intravenously	intravenously	RB
cord-006229-7yoilsho	4385	8	infused	infuse	VBN
cord-006229-7yoilsho	4385	9	Ang-(1	Ang-(1	NNP
cord-006229-7yoilsho	4385	10	-	-	HYPH
cord-006229-7yoilsho	4385	11	7	7	CD
cord-006229-7yoilsho	4385	12	)	)	-RRB-
cord-006229-7yoilsho	4385	13	were	be	VBD
cord-006229-7yoilsho	4385	14	examined	examine	VBN
cord-006229-7yoilsho	4385	15	over	over	IN
cord-006229-7yoilsho	4385	16	four	four	CD
cord-006229-7yoilsho	4385	17	different	different	JJ
cord-006229-7yoilsho	4385	18	time	time	NN
cord-006229-7yoilsho	4385	19	windows	window	NNS
cord-006229-7yoilsho	4385	20	before	before	RB
cord-006229-7yoilsho	4385	21	or	or	CC
cord-006229-7yoilsho	4385	22	after	after	IN
cord-006229-7yoilsho	4385	23	induction	induction	NN
cord-006229-7yoilsho	4385	24	of	of	IN
cord-006229-7yoilsho	4385	25	ALI	ALI	NNP
cord-006229-7yoilsho	4385	26	in	in	IN
cord-006229-7yoilsho	4385	27	male	male	JJ
cord-006229-7yoilsho	4385	28	Sprague	Sprague	NNP
cord-006229-7yoilsho	4385	29	-	-	HYPH
cord-006229-7yoilsho	4385	30	Dawley	Dawley	NNP
cord-006229-7yoilsho	4385	31	rats	rat	NNS
cord-006229-7yoilsho	4385	32	.	.	.
cord-006229-7yoilsho	4386	1	Hemodynamic	Hemodynamic	NNP
cord-006229-7yoilsho	4386	2	effects	effect	NNS
cord-006229-7yoilsho	4386	3	were	be	VBD
cord-006229-7yoilsho	4386	4	continuously	continuously	RB
cord-006229-7yoilsho	4386	5	monitored	monitor	VBN
cord-006229-7yoilsho	4386	6	,	,	,
cord-006229-7yoilsho	4386	7	and	and	CC
cord-006229-7yoilsho	4386	8	loss	loss	NN
cord-006229-7yoilsho	4386	9	of	of	IN
cord-006229-7yoilsho	4386	10	barrier	barrier	NN
cord-006229-7yoilsho	4386	11	function	function	NN
cord-006229-7yoilsho	4386	12	,	,	,
cord-006229-7yoilsho	4386	13	inflammation	inflammation	NN
cord-006229-7yoilsho	4386	14	,	,	,
cord-006229-7yoilsho	4386	15	and	and	CC
cord-006229-7yoilsho	4386	16	lung	lung	NN
cord-006229-7yoilsho	4386	17	peptidase	peptidase	NN
cord-006229-7yoilsho	4386	18	activities	activity	NNS
cord-006229-7yoilsho	4386	19	were	be	VBD
cord-006229-7yoilsho	4386	20	measured	measure	VBN
cord-006229-7yoilsho	4386	21	as	as	IN
cord-006229-7yoilsho	4386	22	experimental	experimental	JJ
cord-006229-7yoilsho	4386	23	endpoints	endpoint	NNS
cord-006229-7yoilsho	4386	24	.	.	.
cord-006229-7yoilsho	4387	1	Key	key	JJ
cord-006229-7yoilsho	4387	2	results	result	NNS
cord-006229-7yoilsho	4387	3	:	:	:
cord-006229-7yoilsho	4387	4	Ang-(1	Ang-(1	NNP
cord-006229-7yoilsho	4387	5	-	-	HYPH
cord-006229-7yoilsho	4387	6	7	7	CD
cord-006229-7yoilsho	4387	7	)	)	-RRB-
cord-006229-7yoilsho	4387	8	infusion	infusion	NN
cord-006229-7yoilsho	4387	9	provided	provide	VBD
cord-006229-7yoilsho	4387	10	best	good	JJS
cord-006229-7yoilsho	4387	11	protection	protection	NN
cord-006229-7yoilsho	4387	12	from	from	IN
cord-006229-7yoilsho	4387	13	experimental	experimental	JJ
cord-006229-7yoilsho	4387	14	ALI	ALI	NNP
cord-006229-7yoilsho	4387	15	when	when	WRB
cord-006229-7yoilsho	4387	16	administered	administer	VBN
cord-006229-7yoilsho	4387	17	by	by	IN
cord-006229-7yoilsho	4387	18	continuous	continuous	JJ
cord-006229-7yoilsho	4387	19	infusion	infusion	NN
cord-006229-7yoilsho	4387	20	starting	start	VBG
cord-006229-7yoilsho	4387	21	30min	30min	NN
cord-006229-7yoilsho	4387	22	after	after	IN
cord-006229-7yoilsho	4387	23	OA	OA	NNP
cord-006229-7yoilsho	4387	24	infusion	infusion	NN
cord-006229-7yoilsho	4387	25	till	till	IN
cord-006229-7yoilsho	4387	26	the	the	DT
cord-006229-7yoilsho	4387	27	end	end	NN
cord-006229-7yoilsho	4387	28	of	of	IN
cord-006229-7yoilsho	4387	29	the	the	DT
cord-006229-7yoilsho	4387	30	experiment	experiment	NN
cord-006229-7yoilsho	4387	31	(	(	-LRB-
cord-006229-7yoilsho	4387	32	30	30	CD
cord-006229-7yoilsho	4387	33	-	-	SYM
cord-006229-7yoilsho	4387	34	240min	240min	CD
cord-006229-7yoilsho	4387	35	)	)	-RRB-
cord-006229-7yoilsho	4387	36	.	.	.
cord-006229-7yoilsho	4388	1	Both	both	DT
cord-006229-7yoilsho	4388	2	pretreatment	pretreatment	NN
cord-006229-7yoilsho	4388	3	(	(	-LRB-
cord-006229-7yoilsho	4388	4	-60	-60	NNS
cord-006229-7yoilsho	4388	5	-	-	HYPH
cord-006229-7yoilsho	4388	6	0min	0min	CD
cord-006229-7yoilsho	4388	7	before	before	IN
cord-006229-7yoilsho	4388	8	OA	OA	NNP
cord-006229-7yoilsho	4388	9	)	)	-RRB-
cord-006229-7yoilsho	4388	10	and	and	CC
cord-006229-7yoilsho	4388	11	short	short	JJ
cord-006229-7yoilsho	4388	12	-	-	HYPH
cord-006229-7yoilsho	4388	13	term	term	NN
cord-006229-7yoilsho	4388	14	therapy	therapy	NN
cord-006229-7yoilsho	4388	15	(	(	-LRB-
cord-006229-7yoilsho	4388	16	30	30	CD
cord-006229-7yoilsho	4388	17	-	-	SYM
cord-006229-7yoilsho	4388	18	90	90	CD
cord-006229-7yoilsho	4388	19	min	min	NN
cord-006229-7yoilsho	4388	20	after	after	IN
cord-006229-7yoilsho	4388	21	OA	OA	NNP
cord-006229-7yoilsho	4388	22	)	)	-RRB-
cord-006229-7yoilsho	4388	23	also	also	RB
cord-006229-7yoilsho	4388	24	had	have	VBD
cord-006229-7yoilsho	4388	25	beneficial	beneficial	JJ
cord-006229-7yoilsho	4388	26	effects	effect	NNS
cord-006229-7yoilsho	4388	27	although	although	IN
cord-006229-7yoilsho	4388	28	less	less	RBR
cord-006229-7yoilsho	4388	29	pronounced	pronounced	JJ
cord-006229-7yoilsho	4388	30	than	than	IN
cord-006229-7yoilsho	4388	31	the	the	DT
cord-006229-7yoilsho	4388	32	effects	effect	NNS
cord-006229-7yoilsho	4388	33	achieved	achieve	VBN
cord-006229-7yoilsho	4388	34	with	with	IN
cord-006229-7yoilsho	4388	35	the	the	DT
cord-006229-7yoilsho	4388	36	optimal	optimal	JJ
cord-006229-7yoilsho	4388	37	therapy	therapy	NN
cord-006229-7yoilsho	4388	38	window	window	NN
cord-006229-7yoilsho	4388	39	.	.	.
cord-006229-7yoilsho	4389	1	Starting	start	VBG
cord-006229-7yoilsho	4389	2	infusion	infusion	NN
cord-006229-7yoilsho	4389	3	of	of	IN
cord-006229-7yoilsho	4389	4	Ang-(1	Ang-(1	NNP
cord-006229-7yoilsho	4389	5	-	-	HYPH
cord-006229-7yoilsho	4389	6	7	7	CD
cord-006229-7yoilsho	4389	7	)	)	-RRB-
cord-006229-7yoilsho	4390	1	90min	90min	JJ
cord-006229-7yoilsho	4391	1	after	after	IN
cord-006229-7yoilsho	4391	2	OA	OA	NNP
cord-006229-7yoilsho	4391	3	(	(	-LRB-
cord-006229-7yoilsho	4391	4	late	late	JJ
cord-006229-7yoilsho	4391	5	-	-	HYPH
cord-006229-7yoilsho	4391	6	term	term	NN
cord-006229-7yoilsho	4391	7	infusion	infusion	NN
cord-006229-7yoilsho	4391	8	)	)	-RRB-
cord-006229-7yoilsho	4391	9	achieved	achieve	VBD
cord-006229-7yoilsho	4391	10	no	no	DT
cord-006229-7yoilsho	4391	11	protective	protective	JJ
cord-006229-7yoilsho	4391	12	effects	effect	NNS
cord-006229-7yoilsho	4391	13	on	on	IN
cord-006229-7yoilsho	4391	14	barrier	barrier	NN
cord-006229-7yoilsho	4391	15	function	function	NN
cord-006229-7yoilsho	4391	16	or	or	CC
cord-006229-7yoilsho	4391	17	hemodynamic	hemodynamic	JJ
cord-006229-7yoilsho	4391	18	alterations	alteration	NNS
cord-006229-7yoilsho	4391	19	,	,	,
cord-006229-7yoilsho	4391	20	but	but	CC
cord-006229-7yoilsho	4391	21	still	still	RB
cord-006229-7yoilsho	4391	22	reduced	reduce	VBN
cord-006229-7yoilsho	4391	23	myeloperoxidase	myeloperoxidase	NN
cord-006229-7yoilsho	4391	24	and	and	CC
cord-006229-7yoilsho	4391	25	angiotensin	angiotensin	NN
cord-006229-7yoilsho	4391	26	converting	convert	VBG
cord-006229-7yoilsho	4391	27	enzyme	enzyme	NN
cord-006229-7yoilsho	4391	28	activity	activity	NN
cord-006229-7yoilsho	4391	29	,	,	,
cord-006229-7yoilsho	4391	30	respectively	respectively	RB
cord-006229-7yoilsho	4391	31	.	.	.
cord-006229-7yoilsho	4392	1	Conclusions	conclusion	NNS
cord-006229-7yoilsho	4392	2	and	and	CC
cord-006229-7yoilsho	4392	3	Implications	implication	NNS
cord-006229-7yoilsho	4392	4	.	.	.
cord-006229-7yoilsho	4393	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	4393	2	findings	finding	NNS
cord-006229-7yoilsho	4393	3	indicate	indicate	VBP
cord-006229-7yoilsho	4393	4	that	that	IN
cord-006229-7yoilsho	4393	5	early	early	JJ
cord-006229-7yoilsho	4393	6	initiation	initiation	NN
cord-006229-7yoilsho	4393	7	of	of	IN
cord-006229-7yoilsho	4393	8	therapy	therapy	NN
cord-006229-7yoilsho	4393	9	after	after	IN
cord-006229-7yoilsho	4393	10	ALI	ALI	NNP
cord-006229-7yoilsho	4393	11	and	and	CC
cord-006229-7yoilsho	4393	12	continuous	continuous	JJ
cord-006229-7yoilsho	4393	13	drug	drug	NN
cord-006229-7yoilsho	4393	14	delivery	delivery	NN
cord-006229-7yoilsho	4393	15	are	be	VBP
cord-006229-7yoilsho	4393	16	most	most	RBS
cord-006229-7yoilsho	4393	17	beneficial	beneficial	JJ
cord-006229-7yoilsho	4393	18	for	for	IN
cord-006229-7yoilsho	4393	19	optimal	optimal	JJ
cord-006229-7yoilsho	4393	20	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	4393	21	efficiency	efficiency	NN
cord-006229-7yoilsho	4393	22	of	of	IN
cord-006229-7yoilsho	4393	23	Ang-(1	Ang-(1	NNP
cord-006229-7yoilsho	4393	24	-	-	HYPH
cord-006229-7yoilsho	4393	25	7	7	CD
cord-006229-7yoilsho	4393	26	)	)	-RRB-
cord-006229-7yoilsho	4393	27	treatment	treatment	NN
cord-006229-7yoilsho	4393	28	in	in	IN
cord-006229-7yoilsho	4393	29	experimental	experimental	JJ
cord-006229-7yoilsho	4393	30	ALI	ALI	NNP
cord-006229-7yoilsho	4393	31	,	,	,
cord-006229-7yoilsho	4393	32	and	and	CC
cord-006229-7yoilsho	4393	33	presumably	presumably	RB
cord-006229-7yoilsho	4393	34	accordingly	accordingly	RB
cord-006229-7yoilsho	4393	35	,	,	,
cord-006229-7yoilsho	4393	36	in	in	IN
cord-006229-7yoilsho	4393	37	clinical	clinical	JJ
cord-006229-7yoilsho	4393	38	ARDS	ARDS	NNP
cord-006229-7yoilsho	4393	39	.	.	.
cord-006229-7yoilsho	4394	1	Airway	airway	JJ
cord-006229-7yoilsho	4394	2	epithelium	epithelium	NN
cord-006229-7yoilsho	4394	3	functions	function	NNS
cord-006229-7yoilsho	4394	4	as	as	IN
cord-006229-7yoilsho	4394	5	a	a	DT
cord-006229-7yoilsho	4394	6	physicochemical	physicochemical	JJ
cord-006229-7yoilsho	4394	7	barrier	barrier	NN
cord-006229-7yoilsho	4394	8	against	against	IN
cord-006229-7yoilsho	4394	9	dust	dust	NN
cord-006229-7yoilsho	4394	10	,	,	,
cord-006229-7yoilsho	4394	11	air	air	NN
cord-006229-7yoilsho	4394	12	pollutants	pollutant	NNS
cord-006229-7yoilsho	4394	13	and	and	CC
cord-006229-7yoilsho	4394	14	other	other	JJ
cord-006229-7yoilsho	4394	15	pathogens	pathogen	NNS
cord-006229-7yoilsho	4394	16	and	and	CC
cord-006229-7yoilsho	4394	17	plays	play	VBZ
cord-006229-7yoilsho	4394	18	a	a	DT
cord-006229-7yoilsho	4394	19	critical	critical	JJ
cord-006229-7yoilsho	4394	20	role	role	NN
cord-006229-7yoilsho	4394	21	in	in	IN
cord-006229-7yoilsho	4394	22	physiological	physiological	JJ
cord-006229-7yoilsho	4394	23	and	and	CC
cord-006229-7yoilsho	4394	24	pathological	pathological	JJ
cord-006229-7yoilsho	4394	25	processes	process	NNS
cord-006229-7yoilsho	4394	26	including	include	VBG
cord-006229-7yoilsho	4394	27	modulation	modulation	NN
cord-006229-7yoilsho	4394	28	of	of	IN
cord-006229-7yoilsho	4394	29	the	the	DT
cord-006229-7yoilsho	4394	30	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	4394	31	response	response	NN
cord-006229-7yoilsho	4394	32	,	,	,
cord-006229-7yoilsho	4394	33	innate	innate	JJ
cord-006229-7yoilsho	4394	34	immunity	immunity	NN
cord-006229-7yoilsho	4394	35	and	and	CC
cord-006229-7yoilsho	4394	36	airway	airway	NN
cord-006229-7yoilsho	4394	37	remodeling	remodeling	NN
cord-006229-7yoilsho	4394	38	such	such	JJ
cord-006229-7yoilsho	4394	39	as	as	IN
cord-006229-7yoilsho	4394	40	in	in	IN
cord-006229-7yoilsho	4394	41	human	human	JJ
cord-006229-7yoilsho	4394	42	asthma	asthma	NN
cord-006229-7yoilsho	4394	43	,	,	,
cord-006229-7yoilsho	4394	44	COPD	COPD	NNP
cord-006229-7yoilsho	4394	45	and	and	CC
cord-006229-7yoilsho	4394	46	equine	equine	JJ
cord-006229-7yoilsho	4394	47	recurrent	recurrent	JJ
cord-006229-7yoilsho	4394	48	airway	airway	NN
cord-006229-7yoilsho	4394	49	obstruction	obstruction	NN
cord-006229-7yoilsho	4394	50	(	(	-LRB-
cord-006229-7yoilsho	4394	51	RAO	RAO	NNP
cord-006229-7yoilsho	4394	52	)	)	-RRB-
cord-006229-7yoilsho	4394	53	.	.	.
cord-006229-7yoilsho	4395	1	Models	model	NNS
cord-006229-7yoilsho	4395	2	of	of	IN
cord-006229-7yoilsho	4395	3	the	the	DT
cord-006229-7yoilsho	4395	4	airway	airway	NN
cord-006229-7yoilsho	4395	5	epithelia	epithelium	NNS
cord-006229-7yoilsho	4395	6	are	be	VBP
cord-006229-7yoilsho	4395	7	,	,	,
cord-006229-7yoilsho	4395	8	indeed	indeed	RB
cord-006229-7yoilsho	4395	9	,	,	,
cord-006229-7yoilsho	4395	10	missing	miss	VBG
cord-006229-7yoilsho	4395	11	for	for	IN
cord-006229-7yoilsho	4395	12	the	the	DT
cord-006229-7yoilsho	4395	13	horse	horse	NN
cord-006229-7yoilsho	4395	14	;	;	:
cord-006229-7yoilsho	4395	15	thus	thus	RB
cord-006229-7yoilsho	4395	16	,	,	,
cord-006229-7yoilsho	4395	17	we	-PRON-	PRP
cord-006229-7yoilsho	4395	18	established	establish	VBD
cord-006229-7yoilsho	4395	19	long	long	JJ
cord-006229-7yoilsho	4395	20	-	-	HYPH
cord-006229-7yoilsho	4395	21	term	term	NN
cord-006229-7yoilsho	4395	22	equine	equine	JJ
cord-006229-7yoilsho	4395	23	bronchial	bronchial	JJ
cord-006229-7yoilsho	4395	24	epithelial	epithelial	JJ
cord-006229-7yoilsho	4395	25	cell	cell	NN
cord-006229-7yoilsho	4395	26	cultures	culture	NNS
cord-006229-7yoilsho	4395	27	using	use	VBG
cord-006229-7yoilsho	4395	28	the	the	DT
cord-006229-7yoilsho	4395	29	ROCK	ROCK	NNP
cord-006229-7yoilsho	4395	30	inhibitor	inhibitor	NN
cord-006229-7yoilsho	4395	31	Y-27632	y-27632	CD
cord-006229-7yoilsho	4395	32	and	and	CC
cord-006229-7yoilsho	4395	33	cell	cell	NN
cord-006229-7yoilsho	4395	34	growth	growth	NN
cord-006229-7yoilsho	4395	35	and	and	CC
cord-006229-7yoilsho	4395	36	differentiation	differentiation	NN
cord-006229-7yoilsho	4395	37	was	be	VBD
cord-006229-7yoilsho	4395	38	characterized	characterize	VBN
cord-006229-7yoilsho	4395	39	.	.	.
cord-006229-7yoilsho	4396	1	Bronchial	bronchial	JJ
cord-006229-7yoilsho	4396	2	epithelial	epithelial	JJ
cord-006229-7yoilsho	4396	3	cells	cell	NNS
cord-006229-7yoilsho	4396	4	(	(	-LRB-
cord-006229-7yoilsho	4396	5	EBEC	EBEC	NNP
cord-006229-7yoilsho	4396	6	)	)	-RRB-
cord-006229-7yoilsho	4396	7	from	from	IN
cord-006229-7yoilsho	4396	8	adult	adult	NN
cord-006229-7yoilsho	4396	9	horses	horse	NNS
cord-006229-7yoilsho	4396	10	were	be	VBD
cord-006229-7yoilsho	4396	11	cultured	culture	VBN
cord-006229-7yoilsho	4396	12	in	in	IN
cord-006229-7yoilsho	4396	13	the	the	DT
cord-006229-7yoilsho	4396	14	presence	presence	NN
cord-006229-7yoilsho	4396	15	and	and	CC
cord-006229-7yoilsho	4396	16	absence	absence	NN
cord-006229-7yoilsho	4396	17	of	of	IN
cord-006229-7yoilsho	4396	18	10	10	CD
cord-006229-7yoilsho	4396	19	µM	µm	CD
cord-006229-7yoilsho	4396	20	Y-27632	y-27632	CD
cord-006229-7yoilsho	4396	21	under	under	IN
cord-006229-7yoilsho	4396	22	conventional	conventional	JJ
cord-006229-7yoilsho	4396	23	and	and	CC
cord-006229-7yoilsho	4396	24	air	air	NN
cord-006229-7yoilsho	4396	25	-	-	HYPH
cord-006229-7yoilsho	4396	26	liquid	liquid	NN
cord-006229-7yoilsho	4396	27	-	-	HYPH
cord-006229-7yoilsho	4396	28	interface	interface	NN
cord-006229-7yoilsho	4396	29	(	(	-LRB-
cord-006229-7yoilsho	4396	30	ALI	ALI	NNP
cord-006229-7yoilsho	4396	31	)	)	-RRB-
cord-006229-7yoilsho	4396	32	culture	culture	NN
cord-006229-7yoilsho	4396	33	conditions	condition	NNS
cord-006229-7yoilsho	4396	34	.	.	.
cord-006229-7yoilsho	4397	1	Cell	cell	NN
cord-006229-7yoilsho	4397	2	proliferation	proliferation	NN
cord-006229-7yoilsho	4397	3	and	and	CC
cord-006229-7yoilsho	4397	4	differentiation	differentiation	NN
cord-006229-7yoilsho	4397	5	were	be	VBD
cord-006229-7yoilsho	4397	6	analyzed	analyze	VBN
cord-006229-7yoilsho	4397	7	.	.	.
cord-006229-7yoilsho	4398	1	Formation	formation	NN
cord-006229-7yoilsho	4398	2	of	of	IN
cord-006229-7yoilsho	4398	3	a	a	DT
cord-006229-7yoilsho	4398	4	functional	functional	JJ
cord-006229-7yoilsho	4398	5	epithelial	epithelial	JJ
cord-006229-7yoilsho	4398	6	barrier	barrier	NN
cord-006229-7yoilsho	4398	7	was	be	VBD
cord-006229-7yoilsho	4398	8	investigated	investigate	VBN
cord-006229-7yoilsho	4398	9	by	by	IN
cord-006229-7yoilsho	4398	10	transepithelial	transepithelial	JJ
cord-006229-7yoilsho	4398	11	electric	electric	JJ
cord-006229-7yoilsho	4398	12	resistance	resistance	NN
cord-006229-7yoilsho	4398	13	(	(	-LRB-
cord-006229-7yoilsho	4398	14	TEER	TEER	NNP
cord-006229-7yoilsho	4398	15	)	)	-RRB-
cord-006229-7yoilsho	4398	16	measurement	measurement	NN
cord-006229-7yoilsho	4398	17	and	and	CC
cord-006229-7yoilsho	4398	18	immunocytochemical	immunocytochemical	JJ
cord-006229-7yoilsho	4398	19	staining	staining	NN
cord-006229-7yoilsho	4398	20	of	of	IN
cord-006229-7yoilsho	4398	21	the	the	DT
cord-006229-7yoilsho	4398	22	Tight	Tight	NNP
cord-006229-7yoilsho	4398	23	-	-	HYPH
cord-006229-7yoilsho	4398	24	Junction	junction	NN
cord-006229-7yoilsho	4398	25	-	-	HYPH
cord-006229-7yoilsho	4398	26	protein	protein	NN
cord-006229-7yoilsho	4399	1	Zonula	zonula	NN
cord-006229-7yoilsho	4400	1	Occludens-1	Occludens-1	NNP
cord-006229-7yoilsho	4400	2	(	(	-LRB-
cord-006229-7yoilsho	4400	3	ZO-1	ZO-1	NNP
cord-006229-7yoilsho	4400	4	)	)	-RRB-
cord-006229-7yoilsho	4400	5	.	.	.
cord-006229-7yoilsho	4401	1	Under	under	IN
cord-006229-7yoilsho	4401	2	conventional	conventional	JJ
cord-006229-7yoilsho	4401	3	culture	culture	NN
cord-006229-7yoilsho	4401	4	,	,	,
cord-006229-7yoilsho	4401	5	Y-27632	y-27632	CD
cord-006229-7yoilsho	4401	6	induced	induce	VBD
cord-006229-7yoilsho	4401	7	higher	high	JJR
cord-006229-7yoilsho	4401	8	growth	growth	NN
cord-006229-7yoilsho	4401	9	rate	rate	NN
cord-006229-7yoilsho	4401	10	of	of	IN
cord-006229-7yoilsho	4401	11	primary	primary	JJ
cord-006229-7yoilsho	4401	12	EBEC	EBEC	NNP
cord-006229-7yoilsho	4401	13	and	and	CC
cord-006229-7yoilsho	4401	14	increased	increase	VBD
cord-006229-7yoilsho	4401	15	the	the	DT
cord-006229-7yoilsho	4401	16	passage	passage	NN
cord-006229-7yoilsho	4401	17	number	number	NN
cord-006229-7yoilsho	4401	18	up	up	IN
cord-006229-7yoilsho	4401	19	to	to	TO
cord-006229-7yoilsho	4401	20	5	5	CD
cord-006229-7yoilsho	4401	21	passages	passage	NNS
cord-006229-7yoilsho	4401	22	with	with	IN
cord-006229-7yoilsho	4401	23	retained	retain	VBN
cord-006229-7yoilsho	4401	24	epithelial	epithelial	JJ
cord-006229-7yoilsho	4401	25	cell	cell	NN
cord-006229-7yoilsho	4401	26	behavior	behavior	NN
cord-006229-7yoilsho	4401	27	.	.	.
cord-006229-7yoilsho	4402	1	In	in	IN
cord-006229-7yoilsho	4402	2	the	the	DT
cord-006229-7yoilsho	4402	3	presence	presence	NN
cord-006229-7yoilsho	4402	4	of	of	IN
cord-006229-7yoilsho	4402	5	Y-27632	y-27632	CD
cord-006229-7yoilsho	4402	6	,	,	,
cord-006229-7yoilsho	4402	7	EBECs	ebec	NNS
cord-006229-7yoilsho	4402	8	under	under	IN
cord-006229-7yoilsho	4402	9	ALI	ALI	NNP
cord-006229-7yoilsho	4402	10	showed	show	VBD
cord-006229-7yoilsho	4402	11	higher	high	JJR
cord-006229-7yoilsho	4402	12	TEER	TEER	NNP
cord-006229-7yoilsho	4402	13	values	value	NNS
cord-006229-7yoilsho	4402	14	.	.	.
cord-006229-7yoilsho	4403	1	Expression	expression	NN
cord-006229-7yoilsho	4403	2	of	of	IN
cord-006229-7yoilsho	4403	3	ZO-1	ZO-1	NNP
cord-006229-7yoilsho	4403	4	correlated	correlate	VBN
cord-006229-7yoilsho	4403	5	with	with	IN
cord-006229-7yoilsho	4403	6	the	the	DT
cord-006229-7yoilsho	4403	7	increase	increase	NN
cord-006229-7yoilsho	4403	8	in	in	IN
cord-006229-7yoilsho	4403	9	TEER	TEER	NNP
cord-006229-7yoilsho	4403	10	,	,	,
cord-006229-7yoilsho	4403	11	but	but	CC
cord-006229-7yoilsho	4403	12	in	in	IN
cord-006229-7yoilsho	4403	13	Y-27632-treated	y-27632-treate	VBN
cord-006229-7yoilsho	4403	14	EBEC	EBEC	NNP
cord-006229-7yoilsho	4403	15	Tight	Tight	NNP
cord-006229-7yoilsho	4403	16	-	-	HYPH
cord-006229-7yoilsho	4403	17	junctionformation	junctionformation	NN
cord-006229-7yoilsho	4403	18	was	be	VBD
cord-006229-7yoilsho	4403	19	more	more	RBR
cord-006229-7yoilsho	4403	20	rapid	rapid	JJ
cord-006229-7yoilsho	4403	21	,	,	,
cord-006229-7yoilsho	4403	22	indicating	indicate	VBG
cord-006229-7yoilsho	4403	23	accelerated	accelerate	VBN
cord-006229-7yoilsho	4403	24	differentiation	differentiation	NN
cord-006229-7yoilsho	4403	25	,	,	,
cord-006229-7yoilsho	4403	26	as	as	RB
cord-006229-7yoilsho	4403	27	well	well	RB
cord-006229-7yoilsho	4403	28	H	h	NN
cord-006229-7yoilsho	4403	29	/	/	SYM
cord-006229-7yoilsho	4403	30	E	e	NN
cord-006229-7yoilsho	4403	31	-	-	NN
cord-006229-7yoilsho	4403	32	staining	stain	VBG
cord-006229-7yoilsho	4403	33	and	and	CC
cord-006229-7yoilsho	4403	34	scanning	scanning	NN
cord-006229-7yoilsho	4403	35	electron	electron	NN
cord-006229-7yoilsho	4403	36	microscopic	microscopic	JJ
cord-006229-7yoilsho	4403	37	imaging	imaging	NN
cord-006229-7yoilsho	4403	38	showed	show	VBD
cord-006229-7yoilsho	4403	39	a	a	DT
cord-006229-7yoilsho	4403	40	higher	high	JJR
cord-006229-7yoilsho	4403	41	amount	amount	NN
cord-006229-7yoilsho	4403	42	of	of	IN
cord-006229-7yoilsho	4403	43	cilia	cilium	NNS
cord-006229-7yoilsho	4403	44	and	and	CC
cord-006229-7yoilsho	4403	45	microvilli	microvilli	NN
cord-006229-7yoilsho	4403	46	and	and	CC
cord-006229-7yoilsho	4403	47	PAS	pas	NN
cord-006229-7yoilsho	4403	48	-	-	HYPH
cord-006229-7yoilsho	4403	49	positive	positive	JJ
cord-006229-7yoilsho	4403	50	cells	cell	NNS
cord-006229-7yoilsho	4403	51	.	.	.
cord-006229-7yoilsho	4404	1	In	in	IN
cord-006229-7yoilsho	4404	2	conclusion	conclusion	NN
cord-006229-7yoilsho	4404	3	,	,	,
cord-006229-7yoilsho	4404	4	the	the	DT
cord-006229-7yoilsho	4404	5	data	datum	NNS
cord-006229-7yoilsho	4404	6	suggest	suggest	VBP
cord-006229-7yoilsho	4404	7	that	that	IN
cord-006229-7yoilsho	4404	8	the	the	DT
cord-006229-7yoilsho	4404	9	ROCK	ROCK	NNP
cord-006229-7yoilsho	4404	10	inhibitor	inhibitor	NN
cord-006229-7yoilsho	4404	11	Y-27632	y-27632	PRP
cord-006229-7yoilsho	4404	12	facilitates	facilitate	VBZ
cord-006229-7yoilsho	4404	13	long	long	JJ
cord-006229-7yoilsho	4404	14	-	-	HYPH
cord-006229-7yoilsho	4404	15	term	term	NN
cord-006229-7yoilsho	4404	16	culture	culture	NN
cord-006229-7yoilsho	4404	17	of	of	IN
cord-006229-7yoilsho	4404	18	equine	equine	JJ
cord-006229-7yoilsho	4404	19	bronchial	bronchial	JJ
cord-006229-7yoilsho	4404	20	epithelial	epithelial	JJ
cord-006229-7yoilsho	4404	21	cells	cell	NNS
cord-006229-7yoilsho	4404	22	which	which	WDT
cord-006229-7yoilsho	4404	23	can	can	MD
cord-006229-7yoilsho	4404	24	be	be	VB
cord-006229-7yoilsho	4404	25	used	use	VBN
cord-006229-7yoilsho	4404	26	to	to	TO
cord-006229-7yoilsho	4404	27	study	study	VB
cord-006229-7yoilsho	4404	28	airway	airway	NN
cord-006229-7yoilsho	4404	29	disease	disease	NN
cord-006229-7yoilsho	4404	30	mechanisms	mechanism	NNS
cord-006229-7yoilsho	4404	31	and	and	CC
cord-006229-7yoilsho	4404	32	to	to	TO
cord-006229-7yoilsho	4404	33	identify	identify	VB
cord-006229-7yoilsho	4404	34	pharmacological	pharmacological	JJ
cord-006229-7yoilsho	4404	35	targets	target	NNS
cord-006229-7yoilsho	4404	36	.	.	.
cord-006229-7yoilsho	4405	1	Leishmaniasis	leishmaniasis	NN
cord-006229-7yoilsho	4405	2	is	be	VBZ
cord-006229-7yoilsho	4405	3	a	a	DT
cord-006229-7yoilsho	4405	4	neglected	neglected	JJ
cord-006229-7yoilsho	4405	5	disease	disease	NN
cord-006229-7yoilsho	4405	6	of	of	IN
cord-006229-7yoilsho	4405	7	tropical	tropical	JJ
cord-006229-7yoilsho	4405	8	and	and	CC
cord-006229-7yoilsho	4405	9	subtropical	subtropical	JJ
cord-006229-7yoilsho	4405	10	regions	region	NNS
cord-006229-7yoilsho	4405	11	with	with	IN
cord-006229-7yoilsho	4405	12	millions	million	NNS
cord-006229-7yoilsho	4405	13	of	of	IN
cord-006229-7yoilsho	4405	14	people	people	NNS
cord-006229-7yoilsho	4405	15	at	at	IN
cord-006229-7yoilsho	4405	16	risk	risk	NN
cord-006229-7yoilsho	4405	17	of	of	IN
cord-006229-7yoilsho	4405	18	infection	infection	NN
cord-006229-7yoilsho	4405	19	with	with	IN
cord-006229-7yoilsho	4405	20	severe	severe	JJ
cord-006229-7yoilsho	4405	21	consequences	consequence	NNS
cord-006229-7yoilsho	4405	22	including	include	VBG
cord-006229-7yoilsho	4405	23	death	death	NN
cord-006229-7yoilsho	4405	24	.	.	.
cord-006229-7yoilsho	4406	1	Current	current	JJ
cord-006229-7yoilsho	4406	2	antileishmanial	antileishmanial	JJ
cord-006229-7yoilsho	4406	3	drugs	drug	NNS
cord-006229-7yoilsho	4406	4	exhibit	exhibit	VBP
cord-006229-7yoilsho	4406	5	serious	serious	JJ
cord-006229-7yoilsho	4406	6	side	side	NN
cord-006229-7yoilsho	4406	7	effects	effect	NNS
cord-006229-7yoilsho	4406	8	and	and	CC
cord-006229-7yoilsho	4406	9	also	also	RB
cord-006229-7yoilsho	4406	10	development	development	NN
cord-006229-7yoilsho	4406	11	of	of	IN
cord-006229-7yoilsho	4406	12	resistances	resistance	NNS
cord-006229-7yoilsho	4406	13	is	be	VBZ
cord-006229-7yoilsho	4406	14	rising	rise	VBG
cord-006229-7yoilsho	4406	15	.	.	.
cord-006229-7yoilsho	4407	1	This	this	DT
cord-006229-7yoilsho	4407	2	disease	disease	NN
cord-006229-7yoilsho	4407	3	is	be	VBZ
cord-006229-7yoilsho	4407	4	caused	cause	VBN
cord-006229-7yoilsho	4407	5	by	by	IN
cord-006229-7yoilsho	4407	6	protozoal	protozoal	NNP
cord-006229-7yoilsho	4407	7	organisms	organism	NNS
cord-006229-7yoilsho	4407	8	from	from	IN
cord-006229-7yoilsho	4407	9	the	the	DT
cord-006229-7yoilsho	4407	10	genus	genus	NN
cord-006229-7yoilsho	4407	11	Leishmania	Leishmania	NNP
cord-006229-7yoilsho	4407	12	.	.	.
cord-006229-7yoilsho	4408	1	In	in	IN
cord-006229-7yoilsho	4408	2	their	-PRON-	PRP$
cord-006229-7yoilsho	4408	3	insect	insect	NN
cord-006229-7yoilsho	4408	4	vector	vector	NN
cord-006229-7yoilsho	4408	5	they	-PRON-	PRP
cord-006229-7yoilsho	4408	6	exist	exist	VBP
cord-006229-7yoilsho	4408	7	in	in	IN
cord-006229-7yoilsho	4408	8	the	the	DT
cord-006229-7yoilsho	4408	9	promastigote	promastigote	NN
cord-006229-7yoilsho	4408	10	form	form	NN
cord-006229-7yoilsho	4408	11	,	,	,
cord-006229-7yoilsho	4408	12	while	while	IN
cord-006229-7yoilsho	4408	13	in	in	IN
cord-006229-7yoilsho	4408	14	the	the	DT
cord-006229-7yoilsho	4408	15	mammalian	mammalian	JJ
cord-006229-7yoilsho	4408	16	host	host	NN
cord-006229-7yoilsho	4408	17	they	-PRON-	PRP
cord-006229-7yoilsho	4408	18	survive	survive	VBP
cord-006229-7yoilsho	4408	19	as	as	IN
cord-006229-7yoilsho	4408	20	amastigotes	amastigote	NNS
cord-006229-7yoilsho	4408	21	inside	inside	IN
cord-006229-7yoilsho	4408	22	the	the	DT
cord-006229-7yoilsho	4408	23	phagolysosomes	phagolysosome	NNS
cord-006229-7yoilsho	4408	24	of	of	IN
cord-006229-7yoilsho	4408	25	macrophages	macrophage	NNS
cord-006229-7yoilsho	4408	26	.	.	.
cord-006229-7yoilsho	4409	1	This	this	DT
cord-006229-7yoilsho	4409	2	makes	make	VBZ
cord-006229-7yoilsho	4409	3	a	a	DT
cord-006229-7yoilsho	4409	4	specific	specific	JJ
cord-006229-7yoilsho	4409	5	pharmacotherapy	pharmacotherapy	NN
cord-006229-7yoilsho	4409	6	complicated	complicated	JJ
cord-006229-7yoilsho	4409	7	.	.	.
cord-006229-7yoilsho	4410	1	Due	due	IN
cord-006229-7yoilsho	4410	2	to	to	IN
cord-006229-7yoilsho	4410	3	the	the	DT
cord-006229-7yoilsho	4410	4	success	success	NN
cord-006229-7yoilsho	4410	5	of	of	IN
cord-006229-7yoilsho	4410	6	artemisinin	artemisinin	NN
cord-006229-7yoilsho	4410	7	in	in	IN
cord-006229-7yoilsho	4410	8	malaria	malaria	NN
cord-006229-7yoilsho	4410	9	therapy	therapy	NN
cord-006229-7yoilsho	4410	10	,	,	,
cord-006229-7yoilsho	4410	11	it	-PRON-	PRP
cord-006229-7yoilsho	4410	12	was	be	VBD
cord-006229-7yoilsho	4410	13	of	of	IN
cord-006229-7yoilsho	4410	14	interest	interest	NN
cord-006229-7yoilsho	4410	15	whether	whether	IN
cord-006229-7yoilsho	4410	16	endoperoxides	endoperoxide	NNS
cord-006229-7yoilsho	4410	17	are	be	VBP
cord-006229-7yoilsho	4410	18	also	also	RB
cord-006229-7yoilsho	4410	19	useful	useful	JJ
cord-006229-7yoilsho	4410	20	to	to	TO
cord-006229-7yoilsho	4410	21	treat	treat	VB
cord-006229-7yoilsho	4410	22	leishmaniasis	leishmaniasis	NN
cord-006229-7yoilsho	4410	23	.	.	.
cord-006229-7yoilsho	4411	1	In	in	IN
cord-006229-7yoilsho	4411	2	a	a	DT
cord-006229-7yoilsho	4411	3	previous	previous	JJ
cord-006229-7yoilsho	4411	4	study	study	NN
cord-006229-7yoilsho	4411	5	we	-PRON-	PRP
cord-006229-7yoilsho	4411	6	demonstrated	demonstrate	VBD
cord-006229-7yoilsho	4411	7	that	that	IN
cord-006229-7yoilsho	4411	8	ascaridole	ascaridole	NNP
cord-006229-7yoilsho	4411	9	,	,	,
cord-006229-7yoilsho	4411	10	an	an	DT
cord-006229-7yoilsho	4411	11	endoperoxide	endoperoxide	NN
cord-006229-7yoilsho	4411	12	from	from	IN
cord-006229-7yoilsho	4411	13	Chenopodium	Chenopodium	NNP
cord-006229-7yoilsho	4411	14	ambrosioides	ambrosioide	NNS
cord-006229-7yoilsho	4411	15	,	,	,
cord-006229-7yoilsho	4411	16	can	can	MD
cord-006229-7yoilsho	4411	17	cure	cure	VB
cord-006229-7yoilsho	4411	18	cutaneous	cutaneous	JJ
cord-006229-7yoilsho	4411	19	leishmaniasis	leishmaniasis	NN
cord-006229-7yoilsho	4411	20	in	in	IN
cord-006229-7yoilsho	4411	21	a	a	DT
cord-006229-7yoilsho	4411	22	mouse	mouse	NN
cord-006229-7yoilsho	4411	23	model	model	NN
cord-006229-7yoilsho	4411	24	and	and	CC
cord-006229-7yoilsho	4411	25	exhibited	exhibit	VBD
cord-006229-7yoilsho	4411	26	IC	IC	NNP
cord-006229-7yoilsho	4411	27	50	50	CD
cord-006229-7yoilsho	4411	28	values	value	NNS
cord-006229-7yoilsho	4411	29	for	for	IN
cord-006229-7yoilsho	4411	30	the	the	DT
cord-006229-7yoilsho	4411	31	viability	viability	NN
cord-006229-7yoilsho	4411	32	in	in	IN
cord-006229-7yoilsho	4411	33	the	the	DT
cord-006229-7yoilsho	4411	34	low	low	JJ
cord-006229-7yoilsho	4411	35	micromolar	micromolar	JJ
cord-006229-7yoilsho	4411	36	range	range	NN
cord-006229-7yoilsho	4411	37	[	[	-LRB-
cord-006229-7yoilsho	4411	38	1	1	CD
cord-006229-7yoilsho	4411	39	]	]	-RRB-
cord-006229-7yoilsho	4411	40	.	.	.
cord-006229-7yoilsho	4412	1	Even	even	RB
cord-006229-7yoilsho	4412	2	though	though	IN
cord-006229-7yoilsho	4412	3	in	in	IN
cord-006229-7yoilsho	4412	4	chemical	chemical	NN
cord-006229-7yoilsho	4412	5	model	model	NN
cord-006229-7yoilsho	4412	6	systems	system	NNS
cord-006229-7yoilsho	4412	7	some	some	DT
cord-006229-7yoilsho	4412	8	basic	basic	JJ
cord-006229-7yoilsho	4412	9	ideas	idea	NNS
cord-006229-7yoilsho	4412	10	about	about	IN
cord-006229-7yoilsho	4412	11	the	the	DT
cord-006229-7yoilsho	4412	12	mechanism	mechanism	NN
cord-006229-7yoilsho	4412	13	of	of	IN
cord-006229-7yoilsho	4412	14	activation	activation	NN
cord-006229-7yoilsho	4412	15	of	of	IN
cord-006229-7yoilsho	4412	16	these	these	DT
cord-006229-7yoilsho	4412	17	endoperoxides	endoperoxide	NNS
cord-006229-7yoilsho	4412	18	exist	exist	VBP
cord-006229-7yoilsho	4412	19	,	,	,
cord-006229-7yoilsho	4412	20	in	in	IN
cord-006229-7yoilsho	4412	21	biological	biological	JJ
cord-006229-7yoilsho	4412	22	systems	system	NNS
cord-006229-7yoilsho	4412	23	including	include	VBG
cord-006229-7yoilsho	4412	24	Leishmania	Leishmania	NNP
cord-006229-7yoilsho	4412	25	parasites	parasite	NNS
cord-006229-7yoilsho	4412	26	this	this	DT
cord-006229-7yoilsho	4412	27	activation	activation	NN
cord-006229-7yoilsho	4412	28	step	step	NN
cord-006229-7yoilsho	4412	29	has	have	VBZ
cord-006229-7yoilsho	4412	30	never	never	RB
cord-006229-7yoilsho	4412	31	been	be	VBN
cord-006229-7yoilsho	4412	32	demonstrated	demonstrate	VBN
cord-006229-7yoilsho	4412	33	.	.	.
cord-006229-7yoilsho	4413	1	Therefore	therefore	RB
cord-006229-7yoilsho	4413	2	,	,	,
cord-006229-7yoilsho	4413	3	we	-PRON-	PRP
cord-006229-7yoilsho	4413	4	set	set	VBD
cord-006229-7yoilsho	4413	5	up	up	RP
cord-006229-7yoilsho	4413	6	experiments	experiment	NNS
cord-006229-7yoilsho	4413	7	to	to	TO
cord-006229-7yoilsho	4413	8	identify	identify	VB
cord-006229-7yoilsho	4413	9	primary	primary	JJ
cord-006229-7yoilsho	4413	10	drug	drug	NN
cord-006229-7yoilsho	4413	11	intermediates	intermediate	NNS
cord-006229-7yoilsho	4413	12	formed	form	VBN
cord-006229-7yoilsho	4413	13	from	from	IN
cord-006229-7yoilsho	4413	14	ascaridole	ascaridole	NNP
cord-006229-7yoilsho	4413	15	by	by	IN
cord-006229-7yoilsho	4413	16	activation	activation	NN
cord-006229-7yoilsho	4413	17	in	in	IN
cord-006229-7yoilsho	4413	18	Leishmania	Leishmania	NNP
cord-006229-7yoilsho	4413	19	tarentolae	tarentolae	NNP
cord-006229-7yoilsho	4413	20	promastigotes	promastigote	NNS
cord-006229-7yoilsho	4413	21	using	use	VBG
cord-006229-7yoilsho	4413	22	electron	electron	NN
cord-006229-7yoilsho	4413	23	spin	spin	NN
cord-006229-7yoilsho	4413	24	resonance	resonance	NN
cord-006229-7yoilsho	4413	25	spectroscopy	spectroscopy	NN
cord-006229-7yoilsho	4413	26	in	in	IN
cord-006229-7yoilsho	4413	27	combination	combination	NN
cord-006229-7yoilsho	4413	28	with	with	IN
cord-006229-7yoilsho	4413	29	spin	spin	NN
cord-006229-7yoilsho	4413	30	trapping	trapping	NN
cord-006229-7yoilsho	4413	31	methods	method	NNS
cord-006229-7yoilsho	4413	32	.	.	.
cord-006229-7yoilsho	4414	1	Ascaridole	Ascaridole	NNP
cord-006229-7yoilsho	4414	2	was	be	VBD
cord-006229-7yoilsho	4414	3	activated	activate	VBN
cord-006229-7yoilsho	4414	4	in	in	IN
cord-006229-7yoilsho	4414	5	a	a	DT
cord-006229-7yoilsho	4414	6	cell	cell	NN
cord-006229-7yoilsho	4414	7	-	-	HYPH
cord-006229-7yoilsho	4414	8	free	free	JJ
cord-006229-7yoilsho	4414	9	system	system	NN
cord-006229-7yoilsho	4414	10	by	by	IN
cord-006229-7yoilsho	4414	11	Fe	Fe	NNP
cord-006229-7yoilsho	4414	12	2	2	CD
cord-006229-7yoilsho	4414	13	+	+	SYM
cord-006229-7yoilsho	4414	14	.	.	.
cord-006229-7yoilsho	4415	1	The	the	DT
cord-006229-7yoilsho	4415	2	radicals	radical	NNS
cord-006229-7yoilsho	4415	3	were	be	VBD
cord-006229-7yoilsho	4415	4	trapped	trap	VBN
cord-006229-7yoilsho	4415	5	by	by	IN
cord-006229-7yoilsho	4415	6	2-methyl-2-nitrosopropane	2-methyl-2-nitrosopropane	CD
cord-006229-7yoilsho	4415	7	(	(	-LRB-
cord-006229-7yoilsho	4415	8	MNP	MNP	NNP
cord-006229-7yoilsho	4415	9	)	)	-RRB-
cord-006229-7yoilsho	4415	10	.	.	.
cord-006229-7yoilsho	4416	1	The	the	DT
cord-006229-7yoilsho	4416	2	resulting	result	VBG
cord-006229-7yoilsho	4416	3	ESR	ESR	NNP
cord-006229-7yoilsho	4416	4	spectra	spectra	NN
cord-006229-7yoilsho	4416	5	consisted	consist	VBN
cord-006229-7yoilsho	4416	6	of	of	IN
cord-006229-7yoilsho	4416	7	the	the	DT
cord-006229-7yoilsho	4416	8	triplet	triplet	NN
cord-006229-7yoilsho	4416	9	of	of	IN
cord-006229-7yoilsho	4416	10	duplets	duplet	NNS
cord-006229-7yoilsho	4416	11	.	.	.
cord-006229-7yoilsho	4417	1	Spectral	spectral	JJ
cord-006229-7yoilsho	4417	2	simulations	simulation	NNS
cord-006229-7yoilsho	4417	3	revealed	reveal	VBD
cord-006229-7yoilsho	4417	4	coupling	coupling	NN
cord-006229-7yoilsho	4417	5	parameters	parameter	NNS
cord-006229-7yoilsho	4417	6	of	of	IN
cord-006229-7yoilsho	4417	7	a	a	DT
cord-006229-7yoilsho	4417	8	N	n	CD
cord-006229-7yoilsho	4417	9	=	=	SYM
cord-006229-7yoilsho	4417	10	16.8	16.8	CD
cord-006229-7yoilsho	4417	11	G	g	NN
cord-006229-7yoilsho	4417	12	,	,	,
cord-006229-7yoilsho	4417	13	and	and	CC
cord-006229-7yoilsho	4418	1	a	a	DT
cord-006229-7yoilsho	4418	2	H	h	NN
cord-006229-7yoilsho	4418	3	=	=	SYM
cord-006229-7yoilsho	4418	4	1.8	1.8	CD
cord-006229-7yoilsho	4418	5	G.	G.	NNP
cord-006229-7yoilsho	4418	6	These	these	DT
cord-006229-7yoilsho	4418	7	coupling	coupling	NN
cord-006229-7yoilsho	4418	8	constants	constant	NNS
cord-006229-7yoilsho	4418	9	are	be	VBP
cord-006229-7yoilsho	4418	10	compatible	compatible	JJ
cord-006229-7yoilsho	4418	11	with	with	IN
cord-006229-7yoilsho	4418	12	iso	iso	NN
cord-006229-7yoilsho	4418	13	-	-	HYPH
cord-006229-7yoilsho	4418	14	propyl	propyl	JJ
cord-006229-7yoilsho	4418	15	radicals	radical	NNS
cord-006229-7yoilsho	4418	16	as	as	IN
cord-006229-7yoilsho	4418	17	primary	primary	JJ
cord-006229-7yoilsho	4418	18	intermediates	intermediate	NNS
cord-006229-7yoilsho	4418	19	.	.	.
cord-006229-7yoilsho	4419	1	In	in	IN
cord-006229-7yoilsho	4419	2	the	the	DT
cord-006229-7yoilsho	4419	3	cellular	cellular	JJ
cord-006229-7yoilsho	4419	4	system	system	NN
cord-006229-7yoilsho	4419	5	,	,	,
cord-006229-7yoilsho	4419	6	consisting	consist	VBG
cord-006229-7yoilsho	4419	7	of	of	IN
cord-006229-7yoilsho	4419	8	Leishmania	Leishmania	NNP
cord-006229-7yoilsho	4419	9	tarentolae	tarentolae	NNP
cord-006229-7yoilsho	4419	10	promastigotes	promastigote	NNS
cord-006229-7yoilsho	4419	11	,	,	,
cord-006229-7yoilsho	4419	12	instead	instead	RB
cord-006229-7yoilsho	4419	13	of	of	IN
cord-006229-7yoilsho	4419	14	MNP	MNP	NNP
cord-006229-7yoilsho	4419	15	the	the	DT
cord-006229-7yoilsho	4419	16	less	less	RBR
cord-006229-7yoilsho	4419	17	cytotoxic	cytotoxic	JJ
cord-006229-7yoilsho	4419	18	5,5-dimethyl-1pyrroline	5,5-dimethyl-1pyrroline	CD
cord-006229-7yoilsho	4419	19	-	-	HYPH
cord-006229-7yoilsho	4419	20	N	n	NN
cord-006229-7yoilsho	4419	21	-	-	HYPH
cord-006229-7yoilsho	4419	22	oxide	oxide	NN
cord-006229-7yoilsho	4419	23	(	(	-LRB-
cord-006229-7yoilsho	4419	24	DMPO	DMPO	NNP
cord-006229-7yoilsho	4419	25	)	)	-RRB-
cord-006229-7yoilsho	4419	26	was	be	VBD
cord-006229-7yoilsho	4419	27	used	use	VBN
cord-006229-7yoilsho	4419	28	for	for	IN
cord-006229-7yoilsho	4419	29	spin	spin	NN
cord-006229-7yoilsho	4419	30	trapping	trapping	NN
cord-006229-7yoilsho	4419	31	.	.	.
cord-006229-7yoilsho	4420	1	Without	without	IN
cord-006229-7yoilsho	4420	2	addition	addition	NN
cord-006229-7yoilsho	4420	3	of	of	IN
cord-006229-7yoilsho	4420	4	Fe	Fe	NNP
cord-006229-7yoilsho	4420	5	2	2	CD
cord-006229-7yoilsho	4420	6	+	+	CC
cord-006229-7yoilsho	4420	7	a	a	DT
cord-006229-7yoilsho	4420	8	six	six	CD
cord-006229-7yoilsho	4420	9	line	line	NN
cord-006229-7yoilsho	4420	10	ESR	ESR	NNP
cord-006229-7yoilsho	4420	11	signal	signal	NN
cord-006229-7yoilsho	4420	12	was	be	VBD
cord-006229-7yoilsho	4420	13	observed	observe	VBN
cord-006229-7yoilsho	4420	14	.	.	.
cord-006229-7yoilsho	4421	1	Spectral	spectral	JJ
cord-006229-7yoilsho	4421	2	simulations	simulation	NNS
cord-006229-7yoilsho	4421	3	of	of	IN
cord-006229-7yoilsho	4421	4	the	the	DT
cord-006229-7yoilsho	4421	5	DMPO	DMPO	NNP
cord-006229-7yoilsho	4421	6	spin	spin	NN
cord-006229-7yoilsho	4421	7	adduct	adduct	NN
cord-006229-7yoilsho	4421	8	revealed	reveal	VBD
cord-006229-7yoilsho	4421	9	coupling	coupling	NN
cord-006229-7yoilsho	4421	10	constants	constant	NNS
cord-006229-7yoilsho	4421	11	of	of	IN
cord-006229-7yoilsho	4421	12	a	a	DT
cord-006229-7yoilsho	4421	13	N	n	CD
cord-006229-7yoilsho	4421	14	=	=	SYM
cord-006229-7yoilsho	4421	15	16.1	16.1	CD
cord-006229-7yoilsho	4421	16	and	and	CC
cord-006229-7yoilsho	4421	17	a	a	DT
cord-006229-7yoilsho	4421	18	H	h	NN
cord-006229-7yoilsho	4421	19	=	=	SYM
cord-006229-7yoilsho	4421	20	24.6	24.6	CD
cord-006229-7yoilsho	4421	21	G.	G.	NNP
cord-006229-7yoilsho	4422	1	According	accord	VBG
cord-006229-7yoilsho	4422	2	to	to	IN
cord-006229-7yoilsho	4422	3	previously	previously	RB
cord-006229-7yoilsho	4422	4	published	publish	VBN
cord-006229-7yoilsho	4422	5	data	datum	NNS
cord-006229-7yoilsho	4422	6	[	[	-LRB-
cord-006229-7yoilsho	4422	7	2	2	CD
cord-006229-7yoilsho	4422	8	]	]	-RRB-
cord-006229-7yoilsho	4422	9	from	from	IN
cord-006229-7yoilsho	4422	10	other	other	JJ
cord-006229-7yoilsho	4422	11	spin	spin	NN
cord-006229-7yoilsho	4422	12	trapping	trapping	NN
cord-006229-7yoilsho	4422	13	experiments	experiment	NNS
cord-006229-7yoilsho	4422	14	,	,	,
cord-006229-7yoilsho	4422	15	this	this	DT
cord-006229-7yoilsho	4422	16	corresponds	correspond	VBZ
cord-006229-7yoilsho	4422	17	to	to	IN
cord-006229-7yoilsho	4422	18	the	the	DT
cord-006229-7yoilsho	4422	19	formation	formation	NN
cord-006229-7yoilsho	4422	20	of	of	IN
cord-006229-7yoilsho	4422	21	carboncentered	carboncentered	JJ
cord-006229-7yoilsho	4422	22	radicals	radical	NNS
cord-006229-7yoilsho	4422	23	from	from	IN
cord-006229-7yoilsho	4422	24	ascaridole	ascaridole	NNP
cord-006229-7yoilsho	4422	25	by	by	IN
cord-006229-7yoilsho	4422	26	Leishmania	Leishmania	NNP
cord-006229-7yoilsho	4422	27	parasites	parasite	NNS
cord-006229-7yoilsho	4422	28	.	.	.
cord-006229-7yoilsho	4423	1	Additional	additional	JJ
cord-006229-7yoilsho	4423	2	experiments	experiment	NNS
cord-006229-7yoilsho	4423	3	using	use	VBG
cord-006229-7yoilsho	4423	4	iron	iron	NN
cord-006229-7yoilsho	4423	5	chelators	chelator	NNS
cord-006229-7yoilsho	4423	6	and	and	CC
cord-006229-7yoilsho	4423	7	antioxidants	antioxidant	NNS
cord-006229-7yoilsho	4423	8	as	as	RB
cord-006229-7yoilsho	4423	9	well	well	RB
cord-006229-7yoilsho	4423	10	as	as	IN
cord-006229-7yoilsho	4423	11	a	a	DT
cord-006229-7yoilsho	4423	12	comparison	comparison	NN
cord-006229-7yoilsho	4423	13	with	with	IN
cord-006229-7yoilsho	4423	14	the	the	DT
cord-006229-7yoilsho	4423	15	endoperoxide	endoperoxide	NNP
cord-006229-7yoilsho	4423	16	artemisinin	artemisinin	NN
cord-006229-7yoilsho	4423	17	were	be	VBD
cord-006229-7yoilsho	4423	18	performed	perform	VBN
cord-006229-7yoilsho	4423	19	.	.	.
cord-006229-7yoilsho	4424	1	In	in	IN
cord-006229-7yoilsho	4424	2	summary	summary	NN
cord-006229-7yoilsho	4424	3	,	,	,
cord-006229-7yoilsho	4424	4	this	this	DT
cord-006229-7yoilsho	4424	5	study	study	NN
cord-006229-7yoilsho	4424	6	for	for	IN
cord-006229-7yoilsho	4424	7	the	the	DT
cord-006229-7yoilsho	4424	8	first	first	JJ
cord-006229-7yoilsho	4424	9	time	time	NN
cord-006229-7yoilsho	4424	10	demonstrated	demonstrate	VBD
cord-006229-7yoilsho	4424	11	the	the	DT
cord-006229-7yoilsho	4424	12	activation	activation	NN
cord-006229-7yoilsho	4424	13	of	of	IN
cord-006229-7yoilsho	4424	14	the	the	DT
cord-006229-7yoilsho	4424	15	endoperoxide	endoperoxide	NNP
cord-006229-7yoilsho	4424	16	ascaridole	ascaridole	NNP
cord-006229-7yoilsho	4424	17	by	by	IN
cord-006229-7yoilsho	4424	18	a	a	DT
cord-006229-7yoilsho	4424	19	protozoal	protozoal	JJ
cord-006229-7yoilsho	4424	20	organism	organism	NN
cord-006229-7yoilsho	4424	21	to	to	IN
cord-006229-7yoilsho	4424	22	its	-PRON-	PRP$
cord-006229-7yoilsho	4424	23	active	active	JJ
cord-006229-7yoilsho	4424	24	intermediate	intermediate	NN
cord-006229-7yoilsho	4424	25	as	as	IN
cord-006229-7yoilsho	4424	26	a	a	DT
cord-006229-7yoilsho	4424	27	prerequisite	prerequisite	NN
cord-006229-7yoilsho	4424	28	to	to	TO
cord-006229-7yoilsho	4424	29	understand	understand	VB
cord-006229-7yoilsho	4424	30	its	-PRON-	PRP$
cord-006229-7yoilsho	4424	31	mechanism	mechanism	NN
cord-006229-7yoilsho	4424	32	of	of	IN
cord-006229-7yoilsho	4424	33	action	action	NN
cord-006229-7yoilsho	4424	34	.	.	.
cord-006229-7yoilsho	4425	1	[	[	-LRB-
cord-006229-7yoilsho	4425	2	1	1	CD
cord-006229-7yoilsho	4425	3	]	]	-RRB-
cord-006229-7yoilsho	4425	4	L.	L.	NNP
cord-006229-7yoilsho	4425	5	Monzote	Monzote	NNP
cord-006229-7yoilsho	4425	6	,	,	,
cord-006229-7yoilsho	4425	7	J.	J.	NNP
cord-006229-7yoilsho	4425	8	Pastor	Pastor	NNP
cord-006229-7yoilsho	4425	9	,	,	,
cord-006229-7yoilsho	4425	10	R.	R.	NNP
cord-006229-7yoilsho	4425	11	Scull	Scull	NNP
cord-006229-7yoilsho	4425	12	,	,	,
cord-006229-7yoilsho	4425	13	and	and	CC
cord-006229-7yoilsho	4425	14	L.	L.	NNP
cord-006229-7yoilsho	4425	15	Gille	Gille	NNP
cord-006229-7yoilsho	4425	16	.	.	.
cord-006229-7yoilsho	4426	1	Antileishmanial	antileishmanial	JJ
cord-006229-7yoilsho	4426	2	activity	activity	NN
cord-006229-7yoilsho	4426	3	of	of	IN
cord-006229-7yoilsho	4426	4	essential	essential	JJ
cord-006229-7yoilsho	4426	5	oil	oil	NN
cord-006229-7yoilsho	4426	6	from	from	IN
cord-006229-7yoilsho	4426	7	Chenopodium	Chenopodium	NNP
cord-006229-7yoilsho	4426	8	ambrosioides	ambrosioide	NNS
cord-006229-7yoilsho	4426	9	and	and	CC
cord-006229-7yoilsho	4426	10	its	-PRON-	PRP$
cord-006229-7yoilsho	4426	11	main	main	JJ
cord-006229-7yoilsho	4426	12	components	component	NNS
cord-006229-7yoilsho	4426	13	against	against	IN
cord-006229-7yoilsho	4426	14	experimental	experimental	JJ
cord-006229-7yoilsho	4426	15	cutaneous	cutaneous	JJ
cord-006229-7yoilsho	4426	16	leishmaniasis	leishmaniasis	NN
cord-006229-7yoilsho	4426	17	in	in	IN
cord-006229-7yoilsho	4426	18	BALB	BALB	NNP
cord-006229-7yoilsho	4426	19	/	/	SYM
cord-006229-7yoilsho	4426	20	c	c	NN
cord-006229-7yoilsho	4426	21	mice	mouse	NNS
cord-006229-7yoilsho	4426	22	.	.	.
cord-006229-7yoilsho	4427	1	Phytomedicine	Phytomedicine	NNP
cord-006229-7yoilsho	4427	2	21:1048	21:1048	CD
cord-006229-7yoilsho	4427	3	-	-	SYM
cord-006229-7yoilsho	4427	4	1052	1052	CD
cord-006229-7yoilsho	4427	5	,	,	,
cord-006229-7yoilsho	4427	6	2014	2014	CD
cord-006229-7yoilsho	4427	7	.	.	.
cord-006229-7yoilsho	4428	1	Nitric	nitric	NN
cord-006229-7yoilsho	4428	2	oxide	oxide	NN
cord-006229-7yoilsho	4428	3	(	(	-LRB-
cord-006229-7yoilsho	4428	4	NO	no	UH
cord-006229-7yoilsho	4428	5	)	)	-RRB-
cord-006229-7yoilsho	4428	6	,	,	,
cord-006229-7yoilsho	4428	7	produced	produce	VBN
cord-006229-7yoilsho	4428	8	by	by	IN
cord-006229-7yoilsho	4428	9	the	the	DT
cord-006229-7yoilsho	4428	10	inducible	inducible	JJ
cord-006229-7yoilsho	4428	11	nitric	nitric	NN
cord-006229-7yoilsho	4428	12	oxide	oxide	NN
cord-006229-7yoilsho	4428	13	synthase	synthase	NN
cord-006229-7yoilsho	4428	14	(	(	-LRB-
cord-006229-7yoilsho	4428	15	iNOS	inos	NN
cord-006229-7yoilsho	4428	16	)	)	-RRB-
cord-006229-7yoilsho	4428	17	has	have	VBZ
cord-006229-7yoilsho	4428	18	many	many	JJ
cord-006229-7yoilsho	4428	19	functions	function	NNS
cord-006229-7yoilsho	4428	20	in	in	IN
cord-006229-7yoilsho	4428	21	physiological	physiological	JJ
cord-006229-7yoilsho	4428	22	and	and	CC
cord-006229-7yoilsho	4428	23	pathophysiological	pathophysiological	JJ
cord-006229-7yoilsho	4428	24	pathways	pathway	NNS
cord-006229-7yoilsho	4428	25	.	.	.
cord-006229-7yoilsho	4429	1	After	after	IN
cord-006229-7yoilsho	4429	2	induction	induction	NN
cord-006229-7yoilsho	4429	3	of	of	IN
cord-006229-7yoilsho	4429	4	iNOS	inos	JJ
cord-006229-7yoilsho	4429	5	expression	expression	NN
cord-006229-7yoilsho	4429	6	by	by	IN
cord-006229-7yoilsho	4429	7	cytokines	cytokine	NNS
cord-006229-7yoilsho	4429	8	and	and	CC
cord-006229-7yoilsho	4429	9	other	other	JJ
cord-006229-7yoilsho	4429	10	agents	agent	NNS
cord-006229-7yoilsho	4430	1	the	the	DT
cord-006229-7yoilsho	4430	2	enzyme	enzyme	NN
cord-006229-7yoilsho	4430	3	produces	produce	VBZ
cord-006229-7yoilsho	4430	4	high	high	JJ
cord-006229-7yoilsho	4430	5	amounts	amount	NNS
cord-006229-7yoilsho	4430	6	of	of	IN
cord-006229-7yoilsho	4430	7	NO	no	DT
cord-006229-7yoilsho	4430	8	in	in	IN
cord-006229-7yoilsho	4430	9	a	a	DT
cord-006229-7yoilsho	4430	10	Ca	Ca	NNP
cord-006229-7yoilsho	4430	11	2	2	CD
cord-006229-7yoilsho	4430	12	+	+	CD
cord-006229-7yoilsho	4430	13	-independent	-independent	JJ
cord-006229-7yoilsho	4430	14	way	way	NN
cord-006229-7yoilsho	4430	15	.	.	.
cord-006229-7yoilsho	4431	1	This	this	DT
cord-006229-7yoilsho	4431	2	high	high	JJ
cord-006229-7yoilsho	4431	3	NO	no	DT
cord-006229-7yoilsho	4431	4	production	production	NN
cord-006229-7yoilsho	4431	5	can	can	MD
cord-006229-7yoilsho	4431	6	have	have	VB
cord-006229-7yoilsho	4431	7	beneficial	beneficial	JJ
cord-006229-7yoilsho	4431	8	microbicidal	microbicidal	NN
cord-006229-7yoilsho	4431	9	,	,	,
cord-006229-7yoilsho	4431	10	antiparasital	antiparasital	NNP
cord-006229-7yoilsho	4431	11	,	,	,
cord-006229-7yoilsho	4431	12	antiviral	antiviral	JJ
cord-006229-7yoilsho	4431	13	and	and	CC
cord-006229-7yoilsho	4431	14	antitumoral	antitumoral	JJ
cord-006229-7yoilsho	4431	15	effects	effect	NNS
cord-006229-7yoilsho	4431	16	.	.	.
cord-006229-7yoilsho	4432	1	In	in	IN
cord-006229-7yoilsho	4432	2	contrast	contrast	NN
cord-006229-7yoilsho	4432	3	,	,	,
cord-006229-7yoilsho	4432	4	aberrant	aberrant	JJ
cord-006229-7yoilsho	4432	5	iNOS	inos	JJ
cord-006229-7yoilsho	4432	6	induction	induction	NN
cord-006229-7yoilsho	4432	7	may	may	MD
cord-006229-7yoilsho	4432	8	have	have	VB
cord-006229-7yoilsho	4432	9	detrimental	detrimental	JJ
cord-006229-7yoilsho	4432	10	consequences	consequence	NNS
cord-006229-7yoilsho	4432	11	and	and	CC
cord-006229-7yoilsho	4432	12	seems	seem	VBZ
cord-006229-7yoilsho	4432	13	to	to	TO
cord-006229-7yoilsho	4432	14	be	be	VB
cord-006229-7yoilsho	4432	15	part	part	NN
cord-006229-7yoilsho	4432	16	of	of	IN
cord-006229-7yoilsho	4432	17	many	many	JJ
cord-006229-7yoilsho	4432	18	diseases	disease	NNS
cord-006229-7yoilsho	4432	19	such	such	JJ
cord-006229-7yoilsho	4432	20	asasthma	asasthma	NNP
cord-006229-7yoilsho	4432	21	,	,	,
cord-006229-7yoilsho	4432	22	arthritis	arthritis	NN
cord-006229-7yoilsho	4432	23	,	,	,
cord-006229-7yoilsho	4432	24	multiple	multiple	JJ
cord-006229-7yoilsho	4432	25	sclerosis	sclerosis	NN
cord-006229-7yoilsho	4432	26	,	,	,
cord-006229-7yoilsho	4432	27	colitis	colitis	NN
cord-006229-7yoilsho	4432	28	,	,	,
cord-006229-7yoilsho	4432	29	psoriasis	psoriasis	NN
cord-006229-7yoilsho	4432	30	,	,	,
cord-006229-7yoilsho	4432	31	neurodegenerative	neurodegenerative	JJ
cord-006229-7yoilsho	4432	32	diseases	disease	NNS
cord-006229-7yoilsho	4432	33	,	,	,
cord-006229-7yoilsho	4432	34	tumor	tumor	NN
cord-006229-7yoilsho	4432	35	development	development	NN
cord-006229-7yoilsho	4432	36	,	,	,
cord-006229-7yoilsho	4432	37	transplant	transplant	NN
cord-006229-7yoilsho	4432	38	rejection	rejection	NN
cord-006229-7yoilsho	4432	39	or	or	CC
cord-006229-7yoilsho	4432	40	septic	septic	JJ
cord-006229-7yoilsho	4432	41	shock	shock	NN
cord-006229-7yoilsho	4432	42	.	.	.
cord-006229-7yoilsho	4433	1	Analysis	analysis	NN
cord-006229-7yoilsho	4433	2	of	of	IN
cord-006229-7yoilsho	4433	3	the	the	DT
cord-006229-7yoilsho	4433	4	human	human	JJ
cord-006229-7yoilsho	4433	5	iNOS	iNOS	NNP
cord-006229-7yoilsho	4433	6	-	-	HYPH
cord-006229-7yoilsho	4433	7	mRNA	mrna	NN
cord-006229-7yoilsho	4433	8	structure	structure	NN
cord-006229-7yoilsho	4433	9	revealed	reveal	VBD
cord-006229-7yoilsho	4433	10	the	the	DT
cord-006229-7yoilsho	4433	11	existence	existence	NN
cord-006229-7yoilsho	4433	12	of	of	IN
cord-006229-7yoilsho	4433	13	an	an	DT
cord-006229-7yoilsho	4433	14	upstream	upstream	JJ
cord-006229-7yoilsho	4433	15	open	open	JJ
cord-006229-7yoilsho	4433	16	reading	reading	NN
cord-006229-7yoilsho	4433	17	frame	frame	NN
cord-006229-7yoilsho	4433	18	(	(	-LRB-
cord-006229-7yoilsho	4433	19	µORF	µORF	NNP
cord-006229-7yoilsho	4433	20	)	)	-RRB-
cord-006229-7yoilsho	4433	21	and	and	CC
cord-006229-7yoilsho	4433	22	a	a	DT
cord-006229-7yoilsho	4433	23	putative	putative	JJ
cord-006229-7yoilsho	4433	24	internal	internal	JJ
cord-006229-7yoilsho	4433	25	ribosome	ribosome	NN
cord-006229-7yoilsho	4433	26	entry	entry	NN
cord-006229-7yoilsho	4433	27	site	site	NN
cord-006229-7yoilsho	4433	28	(	(	-LRB-
cord-006229-7yoilsho	4433	29	IRES	IRES	NNP
cord-006229-7yoilsho	4433	30	)	)	-RRB-
cord-006229-7yoilsho	4433	31	in	in	IN
cord-006229-7yoilsho	4433	32	the	the	DT
cord-006229-7yoilsho	4433	33	5	5	CD
cord-006229-7yoilsho	4433	34	'	'	POS
cord-006229-7yoilsho	4433	35	untranslated	untranslated	JJ
cord-006229-7yoilsho	4433	36	region	region	NN
cord-006229-7yoilsho	4433	37	(	(	-LRB-
cord-006229-7yoilsho	4433	38	5'UTR	5'utr	CD
cord-006229-7yoilsho	4433	39	)	)	-RRB-
cord-006229-7yoilsho	4433	40	in	in	IN
cord-006229-7yoilsho	4433	41	front	front	NN
cord-006229-7yoilsho	4433	42	of	of	IN
cord-006229-7yoilsho	4433	43	the	the	DT
cord-006229-7yoilsho	4433	44	start	start	NN
cord-006229-7yoilsho	4433	45	codon	codon	NN
cord-006229-7yoilsho	4433	46	of	of	IN
cord-006229-7yoilsho	4433	47	the	the	DT
cord-006229-7yoilsho	4433	48	iNOS	inos	JJ
cord-006229-7yoilsho	4433	49	coding	code	VBG
cord-006229-7yoilsho	4433	50	sequence	sequence	NN
cord-006229-7yoilsho	4433	51	(	(	-LRB-
cord-006229-7yoilsho	4433	52	cds	cd	NNS
cord-006229-7yoilsho	4433	53	)	)	-RRB-
cord-006229-7yoilsho	4433	54	.	.	.
cord-006229-7yoilsho	4434	1	To	to	TO
cord-006229-7yoilsho	4434	2	analyze	analyze	VB
cord-006229-7yoilsho	4434	3	the	the	DT
cord-006229-7yoilsho	4434	4	function	function	NN
cord-006229-7yoilsho	4434	5	of	of	IN
cord-006229-7yoilsho	4434	6	the	the	DT
cord-006229-7yoilsho	4434	7	µORF	µorf	NN
cord-006229-7yoilsho	4434	8	and	and	CC
cord-006229-7yoilsho	4434	9	the	the	DT
cord-006229-7yoilsho	4434	10	putative	putative	JJ
cord-006229-7yoilsho	4434	11	IRES	IRES	NNP
cord-006229-7yoilsho	4434	12	we	-PRON-	PRP
cord-006229-7yoilsho	4434	13	cloned	clone	VBD
cord-006229-7yoilsho	4434	14	different	different	JJ
cord-006229-7yoilsho	4434	15	EGFP	EGFP	NNP
cord-006229-7yoilsho	4434	16	and	and	CC
cord-006229-7yoilsho	4434	17	luciferase	luciferase	JJ
cord-006229-7yoilsho	4434	18	reporter	reporter	NN
cord-006229-7yoilsho	4434	19	constructs	construct	NNS
cord-006229-7yoilsho	4434	20	and	and	CC
cord-006229-7yoilsho	4434	21	transfected	transfecte	VBD
cord-006229-7yoilsho	4434	22	them	-PRON-	PRP
cord-006229-7yoilsho	4434	23	into	into	IN
cord-006229-7yoilsho	4434	24	the	the	DT
cord-006229-7yoilsho	4434	25	human	human	JJ
cord-006229-7yoilsho	4434	26	colon	colon	NN
cord-006229-7yoilsho	4434	27	carcinoma	carcinoma	NN
cord-006229-7yoilsho	4434	28	cell	cell	NN
cord-006229-7yoilsho	4434	29	line	line	NN
cord-006229-7yoilsho	4434	30	DLD1	DLD1	NNP
cord-006229-7yoilsho	4434	31	.	.	.
cord-006229-7yoilsho	4435	1	Using	use	VBG
cord-006229-7yoilsho	4435	2	a	a	DT
cord-006229-7yoilsho	4435	3	plasmid	plasmid	NN
cord-006229-7yoilsho	4435	4	construct	construct	NN
cord-006229-7yoilsho	4435	5	with	with	IN
cord-006229-7yoilsho	4435	6	the	the	DT
cord-006229-7yoilsho	4435	7	µORF	µorf	NN
cord-006229-7yoilsho	4435	8	fused	fuse	VBN
cord-006229-7yoilsho	4435	9	with	with	IN
cord-006229-7yoilsho	4435	10	the	the	DT
cord-006229-7yoilsho	4435	11	EGFP	EGFP	NNP
cord-006229-7yoilsho	4435	12	cds	cd	NNS
cord-006229-7yoilsho	4435	13	,	,	,
cord-006229-7yoilsho	4435	14	we	-PRON-	PRP
cord-006229-7yoilsho	4435	15	could	could	MD
cord-006229-7yoilsho	4435	16	show	show	VB
cord-006229-7yoilsho	4435	17	that	that	IN
cord-006229-7yoilsho	4435	18	the	the	DT
cord-006229-7yoilsho	4435	19	µORF	µorf	NN
cord-006229-7yoilsho	4435	20	can	can	MD
cord-006229-7yoilsho	4435	21	be	be	VB
cord-006229-7yoilsho	4435	22	translated	translate	VBN
cord-006229-7yoilsho	4435	23	.	.	.
cord-006229-7yoilsho	4436	1	However	however	RB
cord-006229-7yoilsho	4436	2	,	,	,
cord-006229-7yoilsho	4436	3	compared	compare	VBN
cord-006229-7yoilsho	4436	4	to	to	IN
cord-006229-7yoilsho	4436	5	the	the	DT
cord-006229-7yoilsho	4436	6	positive	positive	JJ
cord-006229-7yoilsho	4436	7	control	control	NN
cord-006229-7yoilsho	4436	8	plasmid	plasmid	NN
cord-006229-7yoilsho	4436	9	less	less	RBR
cord-006229-7yoilsho	4436	10	EGFP	EGFP	NNP
cord-006229-7yoilsho	4436	11	was	be	VBD
cord-006229-7yoilsho	4436	12	produced	produce	VBN
cord-006229-7yoilsho	4436	13	,	,	,
cord-006229-7yoilsho	4436	14	which	which	WDT
cord-006229-7yoilsho	4436	15	can	can	MD
cord-006229-7yoilsho	4436	16	be	be	VB
cord-006229-7yoilsho	4436	17	explained	explain	VBN
cord-006229-7yoilsho	4436	18	by	by	IN
cord-006229-7yoilsho	4436	19	a	a	DT
cord-006229-7yoilsho	4436	20	weak	weak	JJ
cord-006229-7yoilsho	4436	21	Kozak	Kozak	NNP
cord-006229-7yoilsho	4436	22	sequence	sequence	NN
cord-006229-7yoilsho	4436	23	of	of	IN
cord-006229-7yoilsho	4436	24	the	the	DT
cord-006229-7yoilsho	4436	25	µORF	µorf	NN
cord-006229-7yoilsho	4436	26	.	.	.
cord-006229-7yoilsho	4437	1	Blocking	block	VBG
cord-006229-7yoilsho	4437	2	the	the	DT
cord-006229-7yoilsho	4437	3	mRNA	mrna	NN
cord-006229-7yoilsho	4437	4	cap	cap	NN
cord-006229-7yoilsho	4437	5	-	-	HYPH
cord-006229-7yoilsho	4437	6	dependent	dependent	JJ
cord-006229-7yoilsho	4437	7	translation	translation	NN
cord-006229-7yoilsho	4437	8	by	by	IN
cord-006229-7yoilsho	4437	9	cloning	clone	VBG
cord-006229-7yoilsho	4437	10	a	a	DT
cord-006229-7yoilsho	4437	11	stem	stem	NN
cord-006229-7yoilsho	4437	12	loop	loop	NN
cord-006229-7yoilsho	4437	13	structure	structure	NN
cord-006229-7yoilsho	4437	14	in	in	IN
cord-006229-7yoilsho	4437	15	front	front	NN
cord-006229-7yoilsho	4437	16	of	of	IN
cord-006229-7yoilsho	4437	17	the	the	DT
cord-006229-7yoilsho	4437	18	iNOS	inos	JJ
cord-006229-7yoilsho	4437	19	5'UTR	5'utr	CD
cord-006229-7yoilsho	4437	20	within	within	IN
cord-006229-7yoilsho	4437	21	a	a	DT
cord-006229-7yoilsho	4437	22	luciferase	luciferase	NN
cord-006229-7yoilsho	4437	23	reporter	reporter	NN
cord-006229-7yoilsho	4437	24	plasmid	plasmid	NN
cord-006229-7yoilsho	4437	25	led	lead	VBD
cord-006229-7yoilsho	4437	26	to	to	IN
cord-006229-7yoilsho	4437	27	a	a	DT
cord-006229-7yoilsho	4437	28	remarkable	remarkable	JJ
cord-006229-7yoilsho	4437	29	loss	loss	NN
cord-006229-7yoilsho	4437	30	of	of	IN
cord-006229-7yoilsho	4437	31	luciferase	luciferase	NN
cord-006229-7yoilsho	4437	32	production	production	NN
cord-006229-7yoilsho	4437	33	.	.	.
cord-006229-7yoilsho	4438	1	Thus	thus	RB
cord-006229-7yoilsho	4438	2	,	,	,
cord-006229-7yoilsho	4438	3	the	the	DT
cord-006229-7yoilsho	4438	4	expression	expression	NN
cord-006229-7yoilsho	4438	5	of	of	IN
cord-006229-7yoilsho	4438	6	iNOS	inos	NN
cord-006229-7yoilsho	4438	7	seems	seem	VBZ
cord-006229-7yoilsho	4438	8	to	to	TO
cord-006229-7yoilsho	4438	9	be	be	VB
cord-006229-7yoilsho	4438	10	cap	cap	NN
cord-006229-7yoilsho	4438	11	-	-	HYPH
cord-006229-7yoilsho	4438	12	dependent	dependent	JJ
cord-006229-7yoilsho	4438	13	.	.	.
cord-006229-7yoilsho	4439	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	4439	2	,	,	,
cord-006229-7yoilsho	4439	3	transfection	transfection	NN
cord-006229-7yoilsho	4439	4	experiments	experiment	NNS
cord-006229-7yoilsho	4439	5	with	with	IN
cord-006229-7yoilsho	4439	6	DLD1	dld1	JJ
cord-006229-7yoilsho	4439	7	cells	cell	NNS
cord-006229-7yoilsho	4439	8	using	use	VBG
cord-006229-7yoilsho	4439	9	constructs	construct	NNS
cord-006229-7yoilsho	4439	10	coding	code	VBG
cord-006229-7yoilsho	4439	11	for	for	IN
cord-006229-7yoilsho	4439	12	a	a	DT
cord-006229-7yoilsho	4439	13	bicistronic	bicistronic	JJ
cord-006229-7yoilsho	4439	14	renilla	renilla	NNP
cord-006229-7yoilsho	4439	15	-	-	HYPH
cord-006229-7yoilsho	4439	16	firefly	firefly	NNP
cord-006229-7yoilsho	4439	17	luciferase	luciferase	NN
cord-006229-7yoilsho	4439	18	mRNA	mRNA	NNP
cord-006229-7yoilsho	4439	19	showed	show	VBD
cord-006229-7yoilsho	4439	20	that	that	IN
cord-006229-7yoilsho	4439	21	there	there	EX
cord-006229-7yoilsho	4439	22	is	be	VBZ
cord-006229-7yoilsho	4439	23	no	no	DT
cord-006229-7yoilsho	4439	24	IRES	IRES	NNP
cord-006229-7yoilsho	4439	25	in	in	IN
cord-006229-7yoilsho	4439	26	front	front	NN
cord-006229-7yoilsho	4439	27	of	of	IN
cord-006229-7yoilsho	4439	28	the	the	DT
cord-006229-7yoilsho	4439	29	iNOS	inos	NN
cord-006229-7yoilsho	4439	30	cds	cd	NNS
cord-006229-7yoilsho	4439	31	.	.	.
cord-006229-7yoilsho	4440	1	Taken	take	VBN
cord-006229-7yoilsho	4440	2	together	together	RB
cord-006229-7yoilsho	4440	3	,	,	,
cord-006229-7yoilsho	4440	4	the	the	DT
cord-006229-7yoilsho	4440	5	iNOS	inos	JJ
cord-006229-7yoilsho	4440	6	expression	expression	NN
cord-006229-7yoilsho	4440	7	seems	seem	VBZ
cord-006229-7yoilsho	4440	8	to	to	TO
cord-006229-7yoilsho	4440	9	be	be	VB
cord-006229-7yoilsho	4440	10	cap	cap	NN
cord-006229-7yoilsho	4440	11	-	-	HYPH
cord-006229-7yoilsho	4440	12	dependent	dependent	JJ
cord-006229-7yoilsho	4440	13	and	and	CC
cord-006229-7yoilsho	4440	14	without	without	IN
cord-006229-7yoilsho	4440	15	influence	influence	NN
cord-006229-7yoilsho	4440	16	of	of	IN
cord-006229-7yoilsho	4440	17	an	an	DT
cord-006229-7yoilsho	4440	18	IRES	IRES	NNP
cord-006229-7yoilsho	4440	19	,	,	,
cord-006229-7yoilsho	4440	20	while	while	IN
cord-006229-7yoilsho	4440	21	the	the	DT
cord-006229-7yoilsho	4440	22	µORF	µorf	NN
cord-006229-7yoilsho	4440	23	is	be	VBZ
cord-006229-7yoilsho	4440	24	translatable	translatable	JJ
cord-006229-7yoilsho	4440	25	.	.	.
cord-006229-7yoilsho	4441	1	Therefore	therefore	RB
cord-006229-7yoilsho	4441	2	we	-PRON-	PRP
cord-006229-7yoilsho	4441	3	speculate	speculate	VBP
cord-006229-7yoilsho	4441	4	that	that	IN
cord-006229-7yoilsho	4441	5	iNOS	inos	JJ
cord-006229-7yoilsho	4441	6	expression	expression	NN
cord-006229-7yoilsho	4441	7	is	be	VBZ
cord-006229-7yoilsho	4441	8	only	only	RB
cord-006229-7yoilsho	4441	9	possible	possible	JJ
cord-006229-7yoilsho	4441	10	due	due	IN
cord-006229-7yoilsho	4441	11	to	to	IN
cord-006229-7yoilsho	4441	12	a	a	DT
cord-006229-7yoilsho	4441	13	leaky	leaky	JJ
cord-006229-7yoilsho	4441	14	scanning	scanning	NN
cord-006229-7yoilsho	4441	15	mechanism	mechanism	NN
cord-006229-7yoilsho	4441	16	depending	depend	VBG
cord-006229-7yoilsho	4441	17	on	on	IN
cord-006229-7yoilsho	4441	18	the	the	DT
cord-006229-7yoilsho	4441	19	weak	weak	JJ
cord-006229-7yoilsho	4441	20	Kozak	Kozak	NNP
cord-006229-7yoilsho	4441	21	sequence	sequence	NN
cord-006229-7yoilsho	4441	22	of	of	IN
cord-006229-7yoilsho	4441	23	the	the	DT
cord-006229-7yoilsho	4441	24	µORF	µorf	NN
cord-006229-7yoilsho	4441	25	.	.	.
cord-006229-7yoilsho	4442	1	Objectives	objective	NNS
cord-006229-7yoilsho	4442	2	:	:	:
cord-006229-7yoilsho	4443	1	Vascular	vascular	JJ
cord-006229-7yoilsho	4443	2	oxidative	oxidative	JJ
cord-006229-7yoilsho	4443	3	stress	stress	NN
cord-006229-7yoilsho	4443	4	is	be	VBZ
cord-006229-7yoilsho	4443	5	considered	consider	VBN
cord-006229-7yoilsho	4443	6	a	a	DT
cord-006229-7yoilsho	4443	7	pathophysiologic	pathophysiologic	JJ
cord-006229-7yoilsho	4443	8	factor	factor	NN
cord-006229-7yoilsho	4443	9	promoting	promote	VBG
cord-006229-7yoilsho	4443	10	cardiovascular	cardiovascular	JJ
cord-006229-7yoilsho	4443	11	diseases	disease	NNS
cord-006229-7yoilsho	4443	12	such	such	JJ
cord-006229-7yoilsho	4443	13	as	as	IN
cord-006229-7yoilsho	4443	14	coronary	coronary	JJ
cord-006229-7yoilsho	4443	15	artery	artery	NN
cord-006229-7yoilsho	4443	16	disease	disease	NN
cord-006229-7yoilsho	4443	17	,	,	,
cord-006229-7yoilsho	4443	18	heart	heart	NN
cord-006229-7yoilsho	4443	19	failure	failure	NN
cord-006229-7yoilsho	4443	20	,	,	,
cord-006229-7yoilsho	4443	21	diabetes	diabetes	NN
cord-006229-7yoilsho	4443	22	and	and	CC
cord-006229-7yoilsho	4443	23	hypertension	hypertension	NN
cord-006229-7yoilsho	4443	24	.	.	.
cord-006229-7yoilsho	4444	1	There	there	EX
cord-006229-7yoilsho	4444	2	are	be	VBP
cord-006229-7yoilsho	4444	3	several	several	JJ
cord-006229-7yoilsho	4444	4	sources	source	NNS
cord-006229-7yoilsho	4444	5	of	of	IN
cord-006229-7yoilsho	4444	6	superoxide	superoxide	NN
cord-006229-7yoilsho	4444	7	in	in	IN
cord-006229-7yoilsho	4444	8	vascular	vascular	JJ
cord-006229-7yoilsho	4444	9	smooth	smooth	JJ
cord-006229-7yoilsho	4444	10	muscle	muscle	NN
cord-006229-7yoilsho	4444	11	and	and	CC
cord-006229-7yoilsho	4444	12	endothelial	endothelial	JJ
cord-006229-7yoilsho	4444	13	cells	cell	NNS
cord-006229-7yoilsho	4444	14	but	but	CC
cord-006229-7yoilsho	4444	15	whether	whether	IN
cord-006229-7yoilsho	4444	16	an	an	DT
cord-006229-7yoilsho	4444	17	impairment	impairment	NN
cord-006229-7yoilsho	4444	18	of	of	IN
cord-006229-7yoilsho	4444	19	the	the	DT
cord-006229-7yoilsho	4444	20	catalytic	catalytic	JJ
cord-006229-7yoilsho	4444	21	function	function	NN
cord-006229-7yoilsho	4444	22	of	of	IN
cord-006229-7yoilsho	4444	23	eNOS	enos	JJ
cord-006229-7yoilsho	4444	24	and	and	CC
cord-006229-7yoilsho	4444	25	thus	thus	RB
cord-006229-7yoilsho	4444	26	generation	generation	NN
cord-006229-7yoilsho	4444	27	of	of	IN
cord-006229-7yoilsho	4444	28	oxidative	oxidative	JJ
cord-006229-7yoilsho	4444	29	stress	stress	NN
cord-006229-7yoilsho	4444	30	is	be	VBZ
cord-006229-7yoilsho	4444	31	involved	involve	VBN
cord-006229-7yoilsho	4444	32	in	in	IN
cord-006229-7yoilsho	4444	33	blood	blood	NN
cord-006229-7yoilsho	4444	34	pressure	pressure	NN
cord-006229-7yoilsho	4444	35	(	(	-LRB-
cord-006229-7yoilsho	4444	36	BP	BP	NNP
cord-006229-7yoilsho	4444	37	)	)	-RRB-
cord-006229-7yoilsho	4444	38	regulation	regulation	NN
cord-006229-7yoilsho	4444	39	and/or	and/or	CC
cord-006229-7yoilsho	4444	40	the	the	DT
cord-006229-7yoilsho	4444	41	development	development	NN
cord-006229-7yoilsho	4444	42	of	of	IN
cord-006229-7yoilsho	4444	43	hypertensive	hypertensive	JJ
cord-006229-7yoilsho	4444	44	disease	disease	NN
cord-006229-7yoilsho	4444	45	states	state	NNS
cord-006229-7yoilsho	4444	46	is	be	VBZ
cord-006229-7yoilsho	4444	47	unknown	unknown	JJ
cord-006229-7yoilsho	4444	48	.	.	.
cord-006229-7yoilsho	4445	1	Methods	method	NNS
cord-006229-7yoilsho	4445	2	:	:	:
cord-006229-7yoilsho	4445	3	We	-PRON-	PRP
cord-006229-7yoilsho	4445	4	generated	generate	VBD
cord-006229-7yoilsho	4445	5	a	a	DT
cord-006229-7yoilsho	4445	6	mutant	mutant	JJ
cord-006229-7yoilsho	4445	7	eNOS	enos	NN
cord-006229-7yoilsho	4445	8	in	in	IN
cord-006229-7yoilsho	4445	9	which	which	WDT
cord-006229-7yoilsho	4445	10	one	one	CD
cord-006229-7yoilsho	4445	11	of	of	IN
cord-006229-7yoilsho	4445	12	the	the	DT
cord-006229-7yoilsho	4445	13	two	two	CD
cord-006229-7yoilsho	4445	14	essential	essential	JJ
cord-006229-7yoilsho	4445	15	cysteines	cysteine	NNS
cord-006229-7yoilsho	4445	16	required	require	VBN
cord-006229-7yoilsho	4445	17	for	for	IN
cord-006229-7yoilsho	4445	18	the	the	DT
cord-006229-7yoilsho	4445	19	coordination	coordination	NN
cord-006229-7yoilsho	4445	20	with	with	IN
cord-006229-7yoilsho	4445	21	the	the	DT
cord-006229-7yoilsho	4445	22	central	central	JJ
cord-006229-7yoilsho	4445	23	Zn	Zn	NNP
cord-006229-7yoilsho	4445	24	-	-	HYPH
cord-006229-7yoilsho	4445	25	ion	ion	NN
cord-006229-7yoilsho	4445	26	,	,	,
cord-006229-7yoilsho	4445	27	correct	correct	JJ
cord-006229-7yoilsho	4445	28	dimer	dimer	NN
cord-006229-7yoilsho	4445	29	formation	formation	NN
cord-006229-7yoilsho	4445	30	and	and	CC
cord-006229-7yoilsho	4445	31	normal	normal	JJ
cord-006229-7yoilsho	4445	32	activity	activity	NN
cord-006229-7yoilsho	4445	33	is	be	VBZ
cord-006229-7yoilsho	4445	34	replaced	replace	VBN
cord-006229-7yoilsho	4445	35	by	by	IN
cord-006229-7yoilsho	4445	36	alanine	alanine	NN
cord-006229-7yoilsho	4445	37	(	(	-LRB-
cord-006229-7yoilsho	4445	38	C101A	c101a	NN
cord-006229-7yoilsho	4445	39	-	-	HYPH
cord-006229-7yoilsho	4445	40	eNOS	enos	NN
cord-006229-7yoilsho	4445	41	)	)	-RRB-
cord-006229-7yoilsho	4445	42	.	.	.
cord-006229-7yoilsho	4446	1	Normal	normal	JJ
cord-006229-7yoilsho	4446	2	eNOS	enos	JJ
cord-006229-7yoilsho	4446	3	(	(	-LRB-
cord-006229-7yoilsho	4446	4	eNOS	enos	JJ
cord-006229-7yoilsho	4446	5	-	-	HYPH
cord-006229-7yoilsho	4446	6	Tg	Tg	NNP
cord-006229-7yoilsho	4446	7	)	)	-RRB-
cord-006229-7yoilsho	4446	8	or	or	CC
cord-006229-7yoilsho	4446	9	a	a	DT
cord-006229-7yoilsho	4446	10	novel	novel	JJ
cord-006229-7yoilsho	4446	11	dimer	dimer	NN
cord-006229-7yoilsho	4446	12	-	-	HYPH
cord-006229-7yoilsho	4446	13	destabilized	destabilize	VBN
cord-006229-7yoilsho	4446	14	C101A	C101A	NNP
cord-006229-7yoilsho	4446	15	-	-	HYPH
cord-006229-7yoilsho	4446	16	eNOS	enos	NN
cord-006229-7yoilsho	4446	17	described	describe	VBD
cord-006229-7yoilsho	4446	18	previously	previously	RB
cord-006229-7yoilsho	4447	1	(	(	-LRB-
cord-006229-7yoilsho	4447	2	Antioxid	Antioxid	NNP
cord-006229-7yoilsho	4447	3	Redox	Redox	NNP
cord-006229-7yoilsho	4447	4	Signal	Signal	NNP
cord-006229-7yoilsho	4447	5	.	.	.
cord-006229-7yoilsho	4448	1	2015	2015	CD
cord-006229-7yoilsho	4448	2	Sep	Sep	NNP
cord-006229-7yoilsho	4448	3	20	20	CD
cord-006229-7yoilsho	4448	4	;	;	:
cord-006229-7yoilsho	4448	5	23(9	23(9	CD
cord-006229-7yoilsho	4448	6	)	)	-RRB-
cord-006229-7yoilsho	4448	7	:	:	:
cord-006229-7yoilsho	4448	8	711	711	CD
cord-006229-7yoilsho	4448	9	-	-	SYM
cord-006229-7yoilsho	4448	10	23	23	CD
cord-006229-7yoilsho	4448	11	)	)	-RRB-
cord-006229-7yoilsho	4448	12	were	be	VBD
cord-006229-7yoilsho	4448	13	introduced	introduce	VBN
cord-006229-7yoilsho	4448	14	in	in	IN
cord-006229-7yoilsho	4448	15	C57BL/6	C57BL/6	NNP
cord-006229-7yoilsho	4448	16	in	in	IN
cord-006229-7yoilsho	4448	17	an	an	DT
cord-006229-7yoilsho	4448	18	endothelial	endothelial	RB
cord-006229-7yoilsho	4448	19	-	-	HYPH
cord-006229-7yoilsho	4448	20	specific	specific	JJ
cord-006229-7yoilsho	4448	21	manner	manner	NN
cord-006229-7yoilsho	4448	22	.	.	.
cord-006229-7yoilsho	4449	1	Mice	mouse	NNS
cord-006229-7yoilsho	4449	2	were	be	VBD
cord-006229-7yoilsho	4449	3	monitored	monitor	VBN
cord-006229-7yoilsho	4449	4	for	for	IN
cord-006229-7yoilsho	4449	5	eNOS	enos	JJ
cord-006229-7yoilsho	4449	6	expression	expression	NN
cord-006229-7yoilsho	4449	7	and	and	CC
cord-006229-7yoilsho	4449	8	localization	localization	NN
cord-006229-7yoilsho	4449	9	,	,	,
cord-006229-7yoilsho	4449	10	aortic	aortic	JJ
cord-006229-7yoilsho	4449	11	relaxation	relaxation	NN
cord-006229-7yoilsho	4449	12	,	,	,
cord-006229-7yoilsho	4449	13	systolic	systolic	JJ
cord-006229-7yoilsho	4449	14	blood	blood	NN
cord-006229-7yoilsho	4449	15	pressure	pressure	NN
cord-006229-7yoilsho	4449	16	,	,	,
cord-006229-7yoilsho	4449	17	levels	level	NNS
cord-006229-7yoilsho	4449	18	of	of	IN
cord-006229-7yoilsho	4449	19	superoxide	superoxide	NN
cord-006229-7yoilsho	4449	20	and	and	CC
cord-006229-7yoilsho	4449	21	several	several	JJ
cord-006229-7yoilsho	4449	22	post	post	JJ
cord-006229-7yoilsho	4449	23	-	-	JJ
cord-006229-7yoilsho	4449	24	translational	translational	JJ
cord-006229-7yoilsho	4449	25	modifications	modification	NNS
cord-006229-7yoilsho	4449	26	indicating	indicate	VBG
cord-006229-7yoilsho	4449	27	activity	activity	NN
cord-006229-7yoilsho	4449	28	and/or	and/or	CC
cord-006229-7yoilsho	4449	29	increased	increase	VBN
cord-006229-7yoilsho	4449	30	vascular	vascular	JJ
cord-006229-7yoilsho	4449	31	oxidative	oxidative	JJ
cord-006229-7yoilsho	4449	32	stress	stress	NN
cord-006229-7yoilsho	4449	33	.	.	.
cord-006229-7yoilsho	4450	1	Some	some	DT
cord-006229-7yoilsho	4450	2	groups	group	NNS
cord-006229-7yoilsho	4450	3	of	of	IN
cord-006229-7yoilsho	4450	4	mice	mouse	NNS
cord-006229-7yoilsho	4450	5	underwent	undergo	VBD
cord-006229-7yoilsho	4450	6	voluntary	voluntary	JJ
cord-006229-7yoilsho	4450	7	exercise	exercise	NN
cord-006229-7yoilsho	4450	8	training	training	NN
cord-006229-7yoilsho	4450	9	for	for	IN
cord-006229-7yoilsho	4450	10	4	4	CD
cord-006229-7yoilsho	4450	11	weeks	week	NNS
cord-006229-7yoilsho	4450	12	or	or	CC
cord-006229-7yoilsho	4450	13	treatment	treatment	NN
cord-006229-7yoilsho	4450	14	with	with	IN
cord-006229-7yoilsho	4450	15	SOD	SOD	NNP
cord-006229-7yoilsho	4450	16	mimetic	mimetic	NN
cord-006229-7yoilsho	4450	17	Tempol	Tempol	NNP
cord-006229-7yoilsho	4450	18	.	.	.
cord-006229-7yoilsho	4451	1	Results	result	NNS
cord-006229-7yoilsho	4451	2	:	:	:
cord-006229-7yoilsho	4452	1	C101A	C101A	NNP
cord-006229-7yoilsho	4452	2	-	-	HYPH
cord-006229-7yoilsho	4452	3	eNOS	eNOS	NNP
cord-006229-7yoilsho	4452	4	-	-	HYPH
cord-006229-7yoilsho	4452	5	Tg	Tg	NNP
cord-006229-7yoilsho	4452	6	showed	show	VBD
cord-006229-7yoilsho	4452	7	significantly	significantly	RB
cord-006229-7yoilsho	4452	8	increased	increase	VBD
cord-006229-7yoilsho	4452	9	superoxide	superoxide	NN
cord-006229-7yoilsho	4452	10	generation	generation	NN
cord-006229-7yoilsho	4452	11	,	,	,
cord-006229-7yoilsho	4452	12	protein	protein	NN
cord-006229-7yoilsho	4452	13	-	-	HYPH
cord-006229-7yoilsho	4452	14	and	and	CC
cord-006229-7yoilsho	4452	15	eNOS	enos	JJ
cord-006229-7yoilsho	4452	16	-	-	HYPH
cord-006229-7yoilsho	4452	17	tyrosine	tyrosine	NN
cord-006229-7yoilsho	4452	18	-	-	HYPH
cord-006229-7yoilsho	4452	19	nitration	nitration	NN
cord-006229-7yoilsho	4452	20	,	,	,
cord-006229-7yoilsho	4452	21	eNOS	enos	JJ
cord-006229-7yoilsho	4452	22	-	-	HYPH
cord-006229-7yoilsho	4452	23	S	s	NN
cord-006229-7yoilsho	4452	24	-	-	HYPH
cord-006229-7yoilsho	4452	25	glutathionylation	glutathionylation	NN
cord-006229-7yoilsho	4452	26	,	,	,
cord-006229-7yoilsho	4452	27	eNOS	enos	JJ
cord-006229-7yoilsho	4452	28	1176/79	1176/79	CD
cord-006229-7yoilsho	4452	29	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	4452	30	and	and	CC
cord-006229-7yoilsho	4452	31	AMP	amp	NN
cord-006229-7yoilsho	4452	32	kinase	kinase	NN
cord-006229-7yoilsho	4452	33	(	(	-LRB-
cord-006229-7yoilsho	4452	34	AMPKα	AMPKα	NNS
cord-006229-7yoilsho	4452	35	)	)	-RRB-
cord-006229-7yoilsho	4452	36	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	4452	37	at	at	IN
cord-006229-7yoilsho	4452	38	Thr172	thr172	CD
cord-006229-7yoilsho	4452	39	in	in	IN
cord-006229-7yoilsho	4452	40	aorta	aorta	NN
cord-006229-7yoilsho	4452	41	,	,	,
cord-006229-7yoilsho	4452	42	skeletal	skeletal	JJ
cord-006229-7yoilsho	4452	43	muscle	muscle	NN
cord-006229-7yoilsho	4452	44	,	,	,
cord-006229-7yoilsho	4452	45	left	leave	VBN
cord-006229-7yoilsho	4452	46	ventricular	ventricular	JJ
cord-006229-7yoilsho	4452	47	myocardium	myocardium	NN
cord-006229-7yoilsho	4452	48	and	and	CC
cord-006229-7yoilsho	4452	49	lung	lung	NN
cord-006229-7yoilsho	4452	50	as	as	IN
cord-006229-7yoilsho	4452	51	compared	compare	VBN
cord-006229-7yoilsho	4452	52	to	to	IN
cord-006229-7yoilsho	4452	53	eNOS	enos	JJ
cord-006229-7yoilsho	4452	54	-	-	HYPH
cord-006229-7yoilsho	4452	55	Tg	Tg	NNP
cord-006229-7yoilsho	4452	56	and	and	CC
cord-006229-7yoilsho	4452	57	wild	wild	JJ
cord-006229-7yoilsho	4452	58	type	type	NN
cord-006229-7yoilsho	4452	59	(	(	-LRB-
cord-006229-7yoilsho	4452	60	WT	WT	NNP
cord-006229-7yoilsho	4452	61	)	)	-RRB-
cord-006229-7yoilsho	4452	62	controls	control	NNS
cord-006229-7yoilsho	4452	63	.	.	.
cord-006229-7yoilsho	4453	1	The	the	DT
cord-006229-7yoilsho	4453	2	localization	localization	NN
cord-006229-7yoilsho	4453	3	of	of	IN
cord-006229-7yoilsho	4453	4	eNOS	enos	JJ
cord-006229-7yoilsho	4453	5	-	-	HYPH
cord-006229-7yoilsho	4453	6	C101A	C101A	NNP
cord-006229-7yoilsho	4453	7	-	-	HYPH
cord-006229-7yoilsho	4453	8	Tg	Tg	NNP
cord-006229-7yoilsho	4453	9	was	be	VBD
cord-006229-7yoilsho	4453	10	restricted	restrict	VBN
cord-006229-7yoilsho	4453	11	to	to	IN
cord-006229-7yoilsho	4453	12	endothelium	endothelium	NN
cord-006229-7yoilsho	4453	13	as	as	IN
cord-006229-7yoilsho	4453	14	evidenced	evidence	VBN
cord-006229-7yoilsho	4453	15	by	by	IN
cord-006229-7yoilsho	4453	16	immunohistochemically	immunohistochemically	RB
cord-006229-7yoilsho	4453	17	staining	stain	VBG
cord-006229-7yoilsho	4453	18	for	for	IN
cord-006229-7yoilsho	4453	19	eNOS	enos	NN
cord-006229-7yoilsho	4453	20	and	and	CC
cord-006229-7yoilsho	4453	21	an	an	DT
cord-006229-7yoilsho	4453	22	endothelial	endothelial	RB
cord-006229-7yoilsho	4453	23	-	-	HYPH
cord-006229-7yoilsho	4453	24	specific	specific	JJ
cord-006229-7yoilsho	4453	25	marker	marker	NN
cord-006229-7yoilsho	4453	26	CD31	CD31	NNP
cord-006229-7yoilsho	4453	27	.	.	.
cord-006229-7yoilsho	4454	1	Exercise	exercise	NN
cord-006229-7yoilsho	4454	2	training	training	NN
cord-006229-7yoilsho	4454	3	increased	increase	VBD
cord-006229-7yoilsho	4454	4	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	4454	5	of	of	IN
cord-006229-7yoilsho	4454	6	eNOS	enos	NN
cord-006229-7yoilsho	4454	7	at	at	IN
cord-006229-7yoilsho	4454	8	Ser	Ser	NNP
cord-006229-7yoilsho	4454	9	1176/79	1176/79	NNP
cord-006229-7yoilsho	4454	10	and	and	CC
cord-006229-7yoilsho	4454	11	of	of	IN
cord-006229-7yoilsho	4454	12	AMPKα	AMPKα	NNS
cord-006229-7yoilsho	4454	13	at	at	IN
cord-006229-7yoilsho	4454	14	Thr	Thr	NNP
cord-006229-7yoilsho	4454	15	172	172	CD
cord-006229-7yoilsho	4454	16	in	in	IN
cord-006229-7yoilsho	4454	17	WT	WT	NNP
cord-006229-7yoilsho	4454	18	but	but	CC
cord-006229-7yoilsho	4454	19	not	not	RB
cord-006229-7yoilsho	4454	20	in	in	IN
cord-006229-7yoilsho	4454	21	C101A	c101a	NN
cord-006229-7yoilsho	4454	22	-	-	HYPH
cord-006229-7yoilsho	4454	23	eNOS	eNOS	NNP
cord-006229-7yoilsho	4454	24	-	-	HYPH
cord-006229-7yoilsho	4454	25	Tg	Tg	NNP
cord-006229-7yoilsho	4454	26	.	.	.
cord-006229-7yoilsho	4455	1	Aortic	aortic	JJ
cord-006229-7yoilsho	4455	2	endothelium	endothelium	NN
cord-006229-7yoilsho	4455	3	-	-	HYPH
cord-006229-7yoilsho	4455	4	dependent	dependent	JJ
cord-006229-7yoilsho	4455	5	and	and	CC
cord-006229-7yoilsho	4455	6	endothelium	endothelium	NN
cord-006229-7yoilsho	4455	7	-	-	HYPH
cord-006229-7yoilsho	4455	8	independent	independent	JJ
cord-006229-7yoilsho	4455	9	relaxations	relaxation	NNS
cord-006229-7yoilsho	4455	10	were	be	VBD
cord-006229-7yoilsho	4455	11	similar	similar	JJ
cord-006229-7yoilsho	4455	12	in	in	IN
cord-006229-7yoilsho	4455	13	all	all	DT
cord-006229-7yoilsho	4455	14	strains	strain	NNS
cord-006229-7yoilsho	4455	15	.	.	.
cord-006229-7yoilsho	4456	1	In	in	IN
cord-006229-7yoilsho	4456	2	striking	striking	JJ
cord-006229-7yoilsho	4456	3	contrast	contrast	NN
cord-006229-7yoilsho	4456	4	,	,	,
cord-006229-7yoilsho	4456	5	C101A	c101a	NN
cord-006229-7yoilsho	4456	6	-	-	HYPH
cord-006229-7yoilsho	4456	7	eNOS	eNOS	NNP
cord-006229-7yoilsho	4456	8	-	-	HYPH
cord-006229-7yoilsho	4456	9	Tg	Tg	NNP
cord-006229-7yoilsho	4456	10	displayed	display	VBD
cord-006229-7yoilsho	4456	11	normal	normal	JJ
cord-006229-7yoilsho	4456	12	blood	blood	NN
cord-006229-7yoilsho	4456	13	pressure	pressure	NN
cord-006229-7yoilsho	4456	14	despite	despite	IN
cord-006229-7yoilsho	4456	15	higher	high	JJR
cord-006229-7yoilsho	4456	16	levels	level	NNS
cord-006229-7yoilsho	4456	17	of	of	IN
cord-006229-7yoilsho	4456	18	eNOS	enos	NN
cord-006229-7yoilsho	4456	19	,	,	,
cord-006229-7yoilsho	4456	20	while	while	IN
cord-006229-7yoilsho	4456	21	eNOS	enos	JJ
cord-006229-7yoilsho	4456	22	-	-	HYPH
cord-006229-7yoilsho	4456	23	Tg	Tg	NNP
cord-006229-7yoilsho	4456	24	showed	show	VBD
cord-006229-7yoilsho	4456	25	significant	significant	JJ
cord-006229-7yoilsho	4456	26	hypotension	hypotension	NN
cord-006229-7yoilsho	4456	27	.	.	.
cord-006229-7yoilsho	4457	1	Tempol	Tempol	NNP
cord-006229-7yoilsho	4457	2	completely	completely	RB
cord-006229-7yoilsho	4457	3	reversed	reverse	VBD
cord-006229-7yoilsho	4457	4	the	the	DT
cord-006229-7yoilsho	4457	5	occurring	occur	VBG
cord-006229-7yoilsho	4457	6	protein	protein	NN
cord-006229-7yoilsho	4457	7	modifications	modification	NNS
cord-006229-7yoilsho	4457	8	and	and	CC
cord-006229-7yoilsho	4457	9	significantly	significantly	RB
cord-006229-7yoilsho	4457	10	reduced	reduce	VBN
cord-006229-7yoilsho	4457	11	BP	BP	NNP
cord-006229-7yoilsho	4457	12	in	in	IN
cord-006229-7yoilsho	4457	13	C101A	C101A	NNP
cord-006229-7yoilsho	4457	14	-	-	HYPH
cord-006229-7yoilsho	4457	15	eNOS	enos	JJ
cord-006229-7yoilsho	4457	16	-	-	HYPH
cord-006229-7yoilsho	4457	17	Tg	Tg	NNP
cord-006229-7yoilsho	4458	1	but	but	CC
cord-006229-7yoilsho	4458	2	not	not	RB
cord-006229-7yoilsho	4458	3	in	in	IN
cord-006229-7yoilsho	4458	4	WT	WT	NNP
cord-006229-7yoilsho	4458	5	controls	control	NNS
cord-006229-7yoilsho	4458	6	.	.	.
cord-006229-7yoilsho	4459	1	Conclusions	conclusion	NNS
cord-006229-7yoilsho	4459	2	:	:	:
cord-006229-7yoilsho	4460	1	By	by	IN
cord-006229-7yoilsho	4460	2	means	mean	NNS
cord-006229-7yoilsho	4460	3	of	of	IN
cord-006229-7yoilsho	4460	4	a	a	DT
cord-006229-7yoilsho	4460	5	novel	novel	JJ
cord-006229-7yoilsho	4460	6	transgenic	transgenic	JJ
cord-006229-7yoilsho	4460	7	mouse	mouse	NN
cord-006229-7yoilsho	4460	8	model	model	NN
cord-006229-7yoilsho	4460	9	we	-PRON-	PRP
cord-006229-7yoilsho	4460	10	demonstrated	demonstrate	VBD
cord-006229-7yoilsho	4460	11	that	that	IN
cord-006229-7yoilsho	4460	12	vascular	vascular	JJ
cord-006229-7yoilsho	4460	13	oxidative	oxidative	JJ
cord-006229-7yoilsho	4460	14	stress	stress	NN
cord-006229-7yoilsho	4460	15	generated	generate	VBN
cord-006229-7yoilsho	4460	16	by	by	IN
cord-006229-7yoilsho	4460	17	endothelial	endothelial	RB
cord-006229-7yoilsho	4460	18	-	-	HYPH
cord-006229-7yoilsho	4460	19	specific	specific	JJ
cord-006229-7yoilsho	4460	20	expression	expression	NN
cord-006229-7yoilsho	4460	21	of	of	IN
cord-006229-7yoilsho	4460	22	a	a	DT
cord-006229-7yoilsho	4460	23	dimerdestabilized	dimerdestabilized	JJ
cord-006229-7yoilsho	4460	24	variant	variant	NN
cord-006229-7yoilsho	4460	25	of	of	IN
cord-006229-7yoilsho	4460	26	eNOS	enos	NN
cord-006229-7yoilsho	4460	27	selectively	selectively	RB
cord-006229-7yoilsho	4460	28	prevents	prevent	VBZ
cord-006229-7yoilsho	4460	29	BP	BP	NNP
cord-006229-7yoilsho	4460	30	reducing	reduce	VBG
cord-006229-7yoilsho	4460	31	activity	activity	NN
cord-006229-7yoilsho	4460	32	of	of	IN
cord-006229-7yoilsho	4460	33	vascular	vascular	JJ
cord-006229-7yoilsho	4460	34	eNOS	enos	NN
cord-006229-7yoilsho	4460	35	,	,	,
cord-006229-7yoilsho	4460	36	while	while	IN
cord-006229-7yoilsho	4460	37	having	have	VBG
cord-006229-7yoilsho	4460	38	no	no	DT
cord-006229-7yoilsho	4460	39	effect	effect	NN
cord-006229-7yoilsho	4460	40	on	on	IN
cord-006229-7yoilsho	4460	41	aortic	aortic	JJ
cord-006229-7yoilsho	4460	42	endothelial	endothelial	JJ
cord-006229-7yoilsho	4460	43	-	-	HYPH
cord-006229-7yoilsho	4460	44	dependent	dependent	JJ
cord-006229-7yoilsho	4460	45	relaxation	relaxation	NN
cord-006229-7yoilsho	4460	46	.	.	.
cord-006229-7yoilsho	4461	1	These	these	DT
cord-006229-7yoilsho	4461	2	data	datum	NNS
cord-006229-7yoilsho	4461	3	suggest	suggest	VBP
cord-006229-7yoilsho	4461	4	that	that	IN
cord-006229-7yoilsho	4461	5	oxidative	oxidative	JJ
cord-006229-7yoilsho	4461	6	stress	stress	NN
cord-006229-7yoilsho	4461	7	in	in	IN
cord-006229-7yoilsho	4461	8	microvascular	microvascular	JJ
cord-006229-7yoilsho	4461	9	endothelium	endothelium	NN
cord-006229-7yoilsho	4461	10	may	may	MD
cord-006229-7yoilsho	4461	11	play	play	VB
cord-006229-7yoilsho	4461	12	a	a	DT
cord-006229-7yoilsho	4461	13	role	role	NN
cord-006229-7yoilsho	4461	14	in	in	IN
cord-006229-7yoilsho	4461	15	the	the	DT
cord-006229-7yoilsho	4461	16	development	development	NN
cord-006229-7yoilsho	4461	17	of	of	IN
cord-006229-7yoilsho	4461	18	essential	essential	JJ
cord-006229-7yoilsho	4461	19	hypertension	hypertension	NN
cord-006229-7yoilsho	4461	20	.	.	.
cord-006229-7yoilsho	4462	1	The	the	DT
cord-006229-7yoilsho	4462	2	herbal	herbal	JJ
cord-006229-7yoilsho	4462	3	medicinal	medicinal	JJ
cord-006229-7yoilsho	4462	4	product	product	NN
cord-006229-7yoilsho	4462	5	Myrrhinil	Myrrhinil	NNP
cord-006229-7yoilsho	4462	6	-	-	HYPH
cord-006229-7yoilsho	4462	7	Intest	Intest	NNP
cord-006229-7yoilsho	4463	1	®	®	NNP
cord-006229-7yoilsho	4463	2	consists	consist	NNS
cord-006229-7yoilsho	4463	3	of	of	IN
cord-006229-7yoilsho	4463	4	myrrh	myrrh	NN
cord-006229-7yoilsho	4463	5	,	,	,
cord-006229-7yoilsho	4463	6	chamomile	chamomile	NN
cord-006229-7yoilsho	4463	7	flower	flower	NN
cord-006229-7yoilsho	4463	8	dry	dry	JJ
cord-006229-7yoilsho	4463	9	extract	extract	NN
cord-006229-7yoilsho	4463	10	and	and	CC
cord-006229-7yoilsho	4463	11	coffee	coffee	NN
cord-006229-7yoilsho	4463	12	charcoal	charcoal	NN
cord-006229-7yoilsho	4463	13	.	.	.
cord-006229-7yoilsho	4464	1	Clinical	clinical	JJ
cord-006229-7yoilsho	4464	2	data	datum	NNS
cord-006229-7yoilsho	4464	3	prove	prove	VBP
cord-006229-7yoilsho	4464	4	the	the	DT
cord-006229-7yoilsho	4464	5	effectiveness	effectiveness	NN
cord-006229-7yoilsho	4464	6	of	of	IN
cord-006229-7yoilsho	4464	7	this	this	DT
cord-006229-7yoilsho	4464	8	herbal	herbal	JJ
cord-006229-7yoilsho	4464	9	preparation	preparation	NN
cord-006229-7yoilsho	4464	10	for	for	IN
cord-006229-7yoilsho	4464	11	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	4464	12	intestinal	intestinal	JJ
cord-006229-7yoilsho	4464	13	disorders	disorder	NNS
cord-006229-7yoilsho	4464	14	.	.	.
cord-006229-7yoilsho	4465	1	To	to	TO
cord-006229-7yoilsho	4465	2	further	further	RB
cord-006229-7yoilsho	4465	3	investigate	investigate	VB
cord-006229-7yoilsho	4465	4	the	the	DT
cord-006229-7yoilsho	4465	5	anti	anti	JJ
cord-006229-7yoilsho	4465	6	-	-	JJ
cord-006229-7yoilsho	4465	7	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	4465	8	potential	potential	NN
cord-006229-7yoilsho	4465	9	of	of	IN
cord-006229-7yoilsho	4465	10	the	the	DT
cord-006229-7yoilsho	4465	11	single	single	JJ
cord-006229-7yoilsho	4465	12	components	component	NNS
cord-006229-7yoilsho	4465	13	as	as	IN
cord-006229-7yoilsho	4465	14	part	part	NN
cord-006229-7yoilsho	4465	15	of	of	IN
cord-006229-7yoilsho	4465	16	a	a	DT
cord-006229-7yoilsho	4465	17	multi	multi	JJ
cord-006229-7yoilsho	4465	18	-	-	JJ
cord-006229-7yoilsho	4465	19	target	target	JJ
cord-006229-7yoilsho	4465	20	principle	principle	NN
cord-006229-7yoilsho	4465	21	,	,	,
cord-006229-7yoilsho	4465	22	an	an	DT
cord-006229-7yoilsho	4465	23	ethanolic	ethanolic	JJ
cord-006229-7yoilsho	4465	24	(	(	-LRB-
cord-006229-7yoilsho	4465	25	MY	MY	NNP
cord-006229-7yoilsho	4465	26	)	)	-RRB-
cord-006229-7yoilsho	4465	27	and	and	CC
cord-006229-7yoilsho	4465	28	aqueous	aqueous	JJ
cord-006229-7yoilsho	4465	29	(	(	-LRB-
cord-006229-7yoilsho	4465	30	MYA	MYA	NNP
cord-006229-7yoilsho	4465	31	)	)	-RRB-
cord-006229-7yoilsho	4465	32	myrrh	myrrh	NN
cord-006229-7yoilsho	4465	33	extract	extract	NN
cord-006229-7yoilsho	4465	34	,	,	,
cord-006229-7yoilsho	4465	35	ethanolic	ethanolic	JJ
cord-006229-7yoilsho	4465	36	chamomile	chamomile	NN
cord-006229-7yoilsho	4465	37	flower	flower	NN
cord-006229-7yoilsho	4465	38	extract	extract	NN
cord-006229-7yoilsho	4465	39	(	(	-LRB-
cord-006229-7yoilsho	4465	40	KA	KA	NNP
cord-006229-7yoilsho	4465	41	)	)	-RRB-
cord-006229-7yoilsho	4465	42	and	and	CC
cord-006229-7yoilsho	4465	43	aqueous	aqueous	JJ
cord-006229-7yoilsho	4465	44	coffee	coffee	NN
cord-006229-7yoilsho	4465	45	charcoal	charcoal	NN
cord-006229-7yoilsho	4465	46	extract	extract	NN
cord-006229-7yoilsho	4465	47	(	(	-LRB-
cord-006229-7yoilsho	4465	48	CC	CC	NNP
cord-006229-7yoilsho	4465	49	)	)	-RRB-
cord-006229-7yoilsho	4465	50	,	,	,
cord-006229-7yoilsho	4465	51	were	be	VBD
cord-006229-7yoilsho	4465	52	examined	examine	VBN
cord-006229-7yoilsho	4465	53	in	in	IN
cord-006229-7yoilsho	4465	54	an	an	DT
cord-006229-7yoilsho	4465	55	in	in	FW
cord-006229-7yoilsho	4465	56	vitro	vitro	FW
cord-006229-7yoilsho	4465	57	TNBS	TNBS	NNP
cord-006229-7yoilsho	4465	58	inflammation	inflammation	NN
cord-006229-7yoilsho	4465	59	model	model	NN
cord-006229-7yoilsho	4465	60	using	use	VBG
cord-006229-7yoilsho	4465	61	rat	rat	NN
cord-006229-7yoilsho	4465	62	small	small	JJ
cord-006229-7yoilsho	4465	63	intestinal	intestinal	JJ
cord-006229-7yoilsho	4465	64	preparations	preparation	NNS
cord-006229-7yoilsho	4465	65	.	.	.
cord-006229-7yoilsho	4466	1	The	the	DT
cord-006229-7yoilsho	4466	2	effect	effect	NN
cord-006229-7yoilsho	4466	3	of	of	IN
cord-006229-7yoilsho	4466	4	the	the	DT
cord-006229-7yoilsho	4466	5	plant	plant	NN
cord-006229-7yoilsho	4466	6	extracts	extract	NNS
cord-006229-7yoilsho	4466	7	on	on	IN
cord-006229-7yoilsho	4466	8	TNBS	TNBS	NNP
cord-006229-7yoilsho	4466	9	induced	induce	VBD
cord-006229-7yoilsho	4466	10	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	4466	11	damage	damage	NN
cord-006229-7yoilsho	4466	12	was	be	VBD
cord-006229-7yoilsho	4466	13	characterised	characterise	VBN
cord-006229-7yoilsho	4466	14	based	base	VBN
cord-006229-7yoilsho	4466	15	on	on	IN
cord-006229-7yoilsho	4466	16	TNFα	tnfα	NN
cord-006229-7yoilsho	4466	17	-	-	HYPH
cord-006229-7yoilsho	4466	18	gene	gene	NN
cord-006229-7yoilsho	4466	19	expression	expression	NN
cord-006229-7yoilsho	4466	20	analysis	analysis	NN
cord-006229-7yoilsho	4466	21	,	,	,
cord-006229-7yoilsho	4466	22	isometric	isometric	JJ
cord-006229-7yoilsho	4466	23	contraction	contraction	NN
cord-006229-7yoilsho	4466	24	measurement	measurement	NN
cord-006229-7yoilsho	4466	25	and	and	CC
cord-006229-7yoilsho	4466	26	histological	histological	JJ
cord-006229-7yoilsho	4466	27	analysis	analysis	NN
cord-006229-7yoilsho	4466	28	.	.	.
cord-006229-7yoilsho	4467	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	4467	2	,	,	,
cord-006229-7yoilsho	4467	3	TNFα	tnfα	NN
cord-006229-7yoilsho	4467	4	-	-	HYPH
cord-006229-7yoilsho	4467	5	release	release	NN
cord-006229-7yoilsho	4467	6	from	from	IN
cord-006229-7yoilsho	4467	7	LPSstimulated	LPSstimulated	NNP
cord-006229-7yoilsho	4467	8	THP-1	THP-1	NNP
cord-006229-7yoilsho	4467	9	cells	cell	NNS
cord-006229-7yoilsho	4467	10	was	be	VBD
cord-006229-7yoilsho	4467	11	determined	determine	VBN
cord-006229-7yoilsho	4467	12	.	.	.
cord-006229-7yoilsho	4468	1	Budesonide	Budesonide	NNP
cord-006229-7yoilsho	4468	2	was	be	VBD
cord-006229-7yoilsho	4468	3	used	use	VBN
cord-006229-7yoilsho	4468	4	as	as	IN
cord-006229-7yoilsho	4468	5	positive	positive	JJ
cord-006229-7yoilsho	4468	6	control	control	NN
cord-006229-7yoilsho	4468	7	.	.	.
cord-006229-7yoilsho	4469	1	Additionally	additionally	RB
cord-006229-7yoilsho	4469	2	,	,	,
cord-006229-7yoilsho	4469	3	microarray	microarray	NN
cord-006229-7yoilsho	4469	4	gene	gene	NN
cord-006229-7yoilsho	4469	5	expression	expression	NN
cord-006229-7yoilsho	4469	6	analysis	analysis	NN
cord-006229-7yoilsho	4469	7	was	be	VBD
cord-006229-7yoilsho	4469	8	performed	perform	VBN
cord-006229-7yoilsho	4469	9	in	in	IN
cord-006229-7yoilsho	4469	10	LPS	LPS	NNP
cord-006229-7yoilsho	4469	11	/	/	SYM
cord-006229-7yoilsho	4469	12	IFNγ	IFNγ	NNS
cord-006229-7yoilsho	4469	13	stimulated	stimulate	VBD
cord-006229-7yoilsho	4469	14	native	native	JJ
cord-006229-7yoilsho	4469	15	human	human	JJ
cord-006229-7yoilsho	4469	16	macrophages	macrophage	NNS
cord-006229-7yoilsho	4469	17	to	to	TO
cord-006229-7yoilsho	4469	18	determine	determine	VB
cord-006229-7yoilsho	4469	19	potential	potential	JJ
cord-006229-7yoilsho	4469	20	underlying	underlie	VBG
cord-006229-7yoilsho	4469	21	mechanisms	mechanism	NNS
cord-006229-7yoilsho	4469	22	.	.	.
cord-006229-7yoilsho	4470	1	The	the	DT
cord-006229-7yoilsho	4470	2	TNBS	TNBS	NNP
cord-006229-7yoilsho	4470	3	-	-	HYPH
cord-006229-7yoilsho	4470	4	induced	induce	VBN
cord-006229-7yoilsho	4470	5	overexpression	overexpression	NN
cord-006229-7yoilsho	4470	6	of	of	IN
cord-006229-7yoilsho	4470	7	TNFα	TNFα	NNP
cord-006229-7yoilsho	4470	8	-	-	HYPH
cord-006229-7yoilsho	4470	9	mRNA	mRNA	NNP
cord-006229-7yoilsho	4470	10	was	be	VBD
cord-006229-7yoilsho	4470	11	reduced	reduce	VBN
cord-006229-7yoilsho	4470	12	after	after	IN
cord-006229-7yoilsho	4470	13	KA	KA	NNP
cord-006229-7yoilsho	4470	14	(	(	-LRB-
cord-006229-7yoilsho	4470	15	0.1	0.1	CD
cord-006229-7yoilsho	4470	16	mg	mg	NNP
cord-006229-7yoilsho	4470	17	/	/	SYM
cord-006229-7yoilsho	4470	18	ml	ml	NNP
cord-006229-7yoilsho	4470	19	)	)	-RRB-
cord-006229-7yoilsho	4470	20	and	and	CC
cord-006229-7yoilsho	4470	21	MYA	MYA	NNP
cord-006229-7yoilsho	4470	22	(	(	-LRB-
cord-006229-7yoilsho	4470	23	1	1	CD
cord-006229-7yoilsho	4470	24	mg	mg	NNP
cord-006229-7yoilsho	4470	25	/	/	SYM
cord-006229-7yoilsho	4470	26	ml	ml	NN
cord-006229-7yoilsho	4470	27	)	)	-RRB-
cord-006229-7yoilsho	4470	28	treatment	treatment	NN
cord-006229-7yoilsho	4470	29	down	down	RB
cord-006229-7yoilsho	4470	30	to	to	IN
cord-006229-7yoilsho	4470	31	24	24	CD
cord-006229-7yoilsho	4470	32	%	%	NN
cord-006229-7yoilsho	4470	33	and	and	CC
cord-006229-7yoilsho	4470	34	16	16	CD
cord-006229-7yoilsho	4470	35	%	%	NN
cord-006229-7yoilsho	4470	36	resp	resp	NN
cord-006229-7yoilsho	4470	37	.	.	NNP
cord-006229-7yoilsho	4470	38	;	;	:
cord-006229-7yoilsho	4470	39	TNBS	TNBS	NNP
cord-006229-7yoilsho	4470	40	-	-	HYPH
cord-006229-7yoilsho	4470	41	induced	induce	VBN
cord-006229-7yoilsho	4470	42	loss	loss	NN
cord-006229-7yoilsho	4470	43	of	of	IN
cord-006229-7yoilsho	4470	44	contractility	contractility	NN
cord-006229-7yoilsho	4470	45	and	and	CC
cord-006229-7yoilsho	4470	46	reduction	reduction	NN
cord-006229-7yoilsho	4470	47	of	of	IN
cord-006229-7yoilsho	4470	48	mucosal	mucosal	JJ
cord-006229-7yoilsho	4470	49	layer	layer	NN
cord-006229-7yoilsho	4470	50	thickness	thickness	NN
cord-006229-7yoilsho	4470	51	was	be	VBD
cord-006229-7yoilsho	4470	52	inhibited	inhibit	VBN
cord-006229-7yoilsho	4470	53	after	after	IN
cord-006229-7yoilsho	4470	54	KA	KA	NNP
cord-006229-7yoilsho	4470	55	(	(	-LRB-
cord-006229-7yoilsho	4470	56	3	3	CD
cord-006229-7yoilsho	4470	57	mg	mg	NNP
cord-006229-7yoilsho	4470	58	/	/	SYM
cord-006229-7yoilsho	4470	59	ml	ml	NN
cord-006229-7yoilsho	4470	60	)	)	-RRB-
cord-006229-7yoilsho	4470	61	treatment	treatment	NN
cord-006229-7yoilsho	4470	62	by	by	IN
cord-006229-7yoilsho	4470	63	26	26	CD
cord-006229-7yoilsho	4470	64	%	%	NN
cord-006229-7yoilsho	4470	65	and	and	CC
cord-006229-7yoilsho	4470	66	25	25	CD
cord-006229-7yoilsho	4470	67	%	%	NN
cord-006229-7yoilsho	4470	68	resp	resp	NN
cord-006229-7yoilsho	4470	69	.	.	NNP
cord-006229-7yoilsho	4470	70	;	;	:
cord-006229-7yoilsho	4470	71	after	after	IN
cord-006229-7yoilsho	4470	72	MYA	MYA	NNP
cord-006229-7yoilsho	4470	73	(	(	-LRB-
cord-006229-7yoilsho	4470	74	0.1	0.1	CD
cord-006229-7yoilsho	4470	75	-	-	HYPH
cord-006229-7yoilsho	4470	76	1mg	1mg	NNP
cord-006229-7yoilsho	4470	77	/	/	SYM
cord-006229-7yoilsho	4470	78	ml	ml	NN
cord-006229-7yoilsho	4470	79	)	)	-RRB-
cord-006229-7yoilsho	4470	80	treatment	treatment	NN
cord-006229-7yoilsho	4470	81	by	by	IN
cord-006229-7yoilsho	4470	82	17	17	CD
cord-006229-7yoilsho	4470	83	%	%	NN
cord-006229-7yoilsho	4470	84	and	and	CC
cord-006229-7yoilsho	4470	85	44	44	CD
cord-006229-7yoilsho	4470	86	%	%	NN
cord-006229-7yoilsho	4470	87	resp	resp	NN
cord-006229-7yoilsho	4470	88	.	.	.
cord-006229-7yoilsho	4471	1	LPS	LPS	NNP
cord-006229-7yoilsho	4471	2	-	-	HYPH
cord-006229-7yoilsho	4471	3	induced	induce	VBN
cord-006229-7yoilsho	4471	4	TNFα	TNFα	NNP
cord-006229-7yoilsho	4471	5	release	release	NN
cord-006229-7yoilsho	4471	6	from	from	IN
cord-006229-7yoilsho	4471	7	THP-1	THP-1	NNP
cord-006229-7yoilsho	4471	8	cells	cell	NNS
cord-006229-7yoilsho	4471	9	was	be	VBD
cord-006229-7yoilsho	4471	10	inhibited	inhibit	VBN
cord-006229-7yoilsho	4471	11	concentrationdependently	concentrationdependently	RB
cord-006229-7yoilsho	4471	12	by	by	IN
cord-006229-7yoilsho	4471	13	MY	my	PRP$
cord-006229-7yoilsho	4471	14	(	(	-LRB-
cord-006229-7yoilsho	4471	15	IC50	IC50	NNP
cord-006229-7yoilsho	4471	16	=	=	SYM
cord-006229-7yoilsho	4471	17	60.65	60.65	CD
cord-006229-7yoilsho	4471	18	μg	μg	NN
cord-006229-7yoilsho	4471	19	/	/	SYM
cord-006229-7yoilsho	4471	20	ml	ml	NN
cord-006229-7yoilsho	4471	21	;	;	:
cord-006229-7yoilsho	4471	22	97	97	CD
cord-006229-7yoilsho	4471	23	%	%	NN
cord-006229-7yoilsho	4471	24	inhibition	inhibition	NN
cord-006229-7yoilsho	4471	25	)	)	-RRB-
cord-006229-7yoilsho	4471	26	,	,	,
cord-006229-7yoilsho	4471	27	KA	KA	NNP
cord-006229-7yoilsho	4471	28	(	(	-LRB-
cord-006229-7yoilsho	4471	29	IC50	IC50	NNP
cord-006229-7yoilsho	4471	30	=	=	SYM
cord-006229-7yoilsho	4471	31	439	439	CD
cord-006229-7yoilsho	4471	32	μg	μg	NN
cord-006229-7yoilsho	4471	33	/	/	SYM
cord-006229-7yoilsho	4471	34	ml	ml	NN
cord-006229-7yoilsho	4471	35	;	;	:
cord-006229-7yoilsho	4471	36	71	71	CD
cord-006229-7yoilsho	4471	37	%	%	NN
cord-006229-7yoilsho	4471	38	inhibition	inhibition	NN
cord-006229-7yoilsho	4471	39	)	)	-RRB-
cord-006229-7yoilsho	4471	40	and	and	CC
cord-006229-7yoilsho	4471	41	CC	CC	NNP
cord-006229-7yoilsho	4471	42	(	(	-LRB-
cord-006229-7yoilsho	4471	43	IC50	IC50	NNP
cord-006229-7yoilsho	4471	44	=	=	SYM
cord-006229-7yoilsho	4471	45	1886	1886	CD
cord-006229-7yoilsho	4471	46	μg	μg	NNP
cord-006229-7yoilsho	4471	47	/	/	SYM
cord-006229-7yoilsho	4471	48	ml	ml	NN
cord-006229-7yoilsho	4471	49	;	;	:
cord-006229-7yoilsho	4471	50	44	44	CD
cord-006229-7yoilsho	4471	51	%	%	NN
cord-006229-7yoilsho	4471	52	inhibition	inhibition	NN
cord-006229-7yoilsho	4471	53	)	)	-RRB-
cord-006229-7yoilsho	4471	54	.	.	.
cord-006229-7yoilsho	4472	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	4472	2	,	,	,
cord-006229-7yoilsho	4472	3	KA	KA	NNP
cord-006229-7yoilsho	4472	4	(	(	-LRB-
cord-006229-7yoilsho	4472	5	200	200	CD
cord-006229-7yoilsho	4472	6	µg	µg	NN
cord-006229-7yoilsho	4472	7	/	/	SYM
cord-006229-7yoilsho	4472	8	ml	ml	NN
cord-006229-7yoilsho	4472	9	)	)	-RRB-
cord-006229-7yoilsho	4472	10	and	and	CC
cord-006229-7yoilsho	4472	11	CC	CC	NNP
cord-006229-7yoilsho	4472	12	(	(	-LRB-
cord-006229-7yoilsho	4472	13	500	500	CD
cord-006229-7yoilsho	4472	14	µg	µg	NN
cord-006229-7yoilsho	4472	15	/	/	SYM
cord-006229-7yoilsho	4472	16	ml	ml	NN
cord-006229-7yoilsho	4472	17	)	)	-RRB-
cord-006229-7yoilsho	4472	18	inhibited	inhibit	VBD
cord-006229-7yoilsho	4472	19	the	the	DT
cord-006229-7yoilsho	4472	20	LPS	lp	NNS
cord-006229-7yoilsho	4472	21	/	/	SYM
cord-006229-7yoilsho	4472	22	IFNγ	IFNγ	NNS
cord-006229-7yoilsho	4472	23	-	-	HYPH
cord-006229-7yoilsho	4472	24	induced	induce	VBN
cord-006229-7yoilsho	4472	25	expression	expression	NN
cord-006229-7yoilsho	4472	26	of	of	IN
cord-006229-7yoilsho	4472	27	genes	gene	NNS
cord-006229-7yoilsho	4472	28	associated	associate	VBN
cord-006229-7yoilsho	4472	29	with	with	IN
cord-006229-7yoilsho	4472	30	chemokine	chemokine	NN
cord-006229-7yoilsho	4472	31	signalling	signal	VBG
cord-006229-7yoilsho	4472	32	up	up	IN
cord-006229-7yoilsho	4472	33	to	to	IN
cord-006229-7yoilsho	4472	34	100-fold	100-fold	CD
cord-006229-7yoilsho	4472	35	(	(	-LRB-
cord-006229-7yoilsho	4472	36	for	for	IN
cord-006229-7yoilsho	4472	37	CXCL13	CXCL13	NNP
cord-006229-7yoilsho	4472	38	)	)	-RRB-
cord-006229-7yoilsho	4472	39	.	.	.
cord-006229-7yoilsho	4473	1	The	the	DT
cord-006229-7yoilsho	4473	2	presented	present	VBN
cord-006229-7yoilsho	4473	3	study	study	NN
cord-006229-7yoilsho	4473	4	demonstrates	demonstrate	VBZ
cord-006229-7yoilsho	4473	5	further	further	JJ
cord-006229-7yoilsho	4473	6	evidence	evidence	NN
cord-006229-7yoilsho	4473	7	for	for	IN
cord-006229-7yoilsho	4473	8	anti	anti	JJ
cord-006229-7yoilsho	4473	9	-	-	JJ
cord-006229-7yoilsho	4473	10	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	4473	11	properties	property	NNS
cord-006229-7yoilsho	4473	12	of	of	IN
cord-006229-7yoilsho	4473	13	the	the	DT
cord-006229-7yoilsho	4473	14	herbal	herbal	JJ
cord-006229-7yoilsho	4473	15	components	component	NNS
cord-006229-7yoilsho	4473	16	which	which	WDT
cord-006229-7yoilsho	4473	17	contribute	contribute	VBP
cord-006229-7yoilsho	4473	18	to	to	IN
cord-006229-7yoilsho	4473	19	the	the	DT
cord-006229-7yoilsho	4473	20	reported	report	VBN
cord-006229-7yoilsho	4473	21	clinical	clinical	JJ
cord-006229-7yoilsho	4473	22	effectiveness	effectiveness	NN
cord-006229-7yoilsho	4473	23	.	.	.
cord-006229-7yoilsho	4474	1	Introduction	introduction	NN
cord-006229-7yoilsho	4474	2	:	:	:
cord-006229-7yoilsho	4475	1	The	the	DT
cord-006229-7yoilsho	4475	2	purine	purine	NN
cord-006229-7yoilsho	4475	3	nucleoside	nucleoside	NN
cord-006229-7yoilsho	4475	4	adenosine	adenosine	NN
cord-006229-7yoilsho	4475	5	,	,	,
cord-006229-7yoilsho	4475	6	which	which	WDT
cord-006229-7yoilsho	4475	7	is	be	VBZ
cord-006229-7yoilsho	4475	8	involved	involve	VBN
cord-006229-7yoilsho	4475	9	in	in	IN
cord-006229-7yoilsho	4475	10	a	a	DT
cord-006229-7yoilsho	4475	11	variety	variety	NN
cord-006229-7yoilsho	4475	12	of	of	IN
cord-006229-7yoilsho	4475	13	physiological	physiological	JJ
cord-006229-7yoilsho	4475	14	functions	function	NNS
cord-006229-7yoilsho	4475	15	,	,	,
cord-006229-7yoilsho	4475	16	regulates	regulate	VBZ
cord-006229-7yoilsho	4475	17	immune	immune	JJ
cord-006229-7yoilsho	4475	18	and	and	CC
cord-006229-7yoilsho	4475	19	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	4475	20	responses	response	NNS
cord-006229-7yoilsho	4475	21	and	and	CC
cord-006229-7yoilsho	4475	22	acts	act	VBZ
cord-006229-7yoilsho	4475	23	as	as	IN
cord-006229-7yoilsho	4475	24	a	a	DT
cord-006229-7yoilsho	4475	25	modulator	modulator	NN
cord-006229-7yoilsho	4475	26	of	of	IN
cord-006229-7yoilsho	4475	27	gut	gut	NN
cord-006229-7yoilsho	4475	28	functions	function	NNS
cord-006229-7yoilsho	4475	29	.	.	.
cord-006229-7yoilsho	4476	1	Although	although	IN
cord-006229-7yoilsho	4476	2	it	-PRON-	PRP
cord-006229-7yoilsho	4476	3	is	be	VBZ
cord-006229-7yoilsho	4476	4	present	present	JJ
cord-006229-7yoilsho	4476	5	at	at	IN
cord-006229-7yoilsho	4476	6	low	low	JJ
cord-006229-7yoilsho	4476	7	concentrations	concentration	NNS
cord-006229-7yoilsho	4476	8	in	in	IN
cord-006229-7yoilsho	4476	9	the	the	DT
cord-006229-7yoilsho	4476	10	extracellular	extracellular	JJ
cord-006229-7yoilsho	4476	11	space	space	NN
cord-006229-7yoilsho	4476	12	,	,	,
cord-006229-7yoilsho	4476	13	stressful	stressful	JJ
cord-006229-7yoilsho	4476	14	conditions	condition	NNS
cord-006229-7yoilsho	4476	15	,	,	,
cord-006229-7yoilsho	4476	16	such	such	JJ
cord-006229-7yoilsho	4476	17	as	as	IN
cord-006229-7yoilsho	4476	18	inflammation	inflammation	NN
cord-006229-7yoilsho	4476	19	,	,	,
cord-006229-7yoilsho	4476	20	can	can	MD
cord-006229-7yoilsho	4476	21	markedly	markedly	RB
cord-006229-7yoilsho	4476	22	increase	increase	VB
cord-006229-7yoilsho	4476	23	its	-PRON-	PRP$
cord-006229-7yoilsho	4476	24	extracellular	extracellular	JJ
cord-006229-7yoilsho	4476	25	level	level	NN
cord-006229-7yoilsho	4476	26	up	up	IN
cord-006229-7yoilsho	4476	27	to	to	IN
cord-006229-7yoilsho	4476	28	micromolar	micromolar	JJ
cord-006229-7yoilsho	4476	29	range	range	NN
cord-006229-7yoilsho	4476	30	.	.	.
cord-006229-7yoilsho	4477	1	By	by	IN
cord-006229-7yoilsho	4477	2	activation	activation	NN
cord-006229-7yoilsho	4477	3	of	of	IN
cord-006229-7yoilsho	4477	4	different	different	JJ
cord-006229-7yoilsho	4477	5	receptor	receptor	NN
cord-006229-7yoilsho	4477	6	subtypes	subtype	NNS
cord-006229-7yoilsho	4477	7	adenosine	adenosine	NN
cord-006229-7yoilsho	4477	8	is	be	VBZ
cord-006229-7yoilsho	4477	9	able	able	JJ
cord-006229-7yoilsho	4477	10	to	to	TO
cord-006229-7yoilsho	4477	11	induce	induce	VB
cord-006229-7yoilsho	4477	12	anti	anti	JJ
cord-006229-7yoilsho	4477	13	-	-	JJ
cord-006229-7yoilsho	4477	14	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	4477	15	or	or	CC
cord-006229-7yoilsho	4477	16	pro	pro	JJ
cord-006229-7yoilsho	4477	17	-	-	JJ
cord-006229-7yoilsho	4477	18	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	4477	19	impacts	impact	NNS
cord-006229-7yoilsho	4477	20	.	.	.
cord-006229-7yoilsho	4478	1	Aim	aim	VB
cord-006229-7yoilsho	4479	1	:	:	:
cord-006229-7yoilsho	4479	2	The	the	DT
cord-006229-7yoilsho	4479	3	current	current	JJ
cord-006229-7yoilsho	4479	4	study	study	NN
cord-006229-7yoilsho	4479	5	examined	examine	VBD
cord-006229-7yoilsho	4479	6	the	the	DT
cord-006229-7yoilsho	4479	7	impact	impact	NN
cord-006229-7yoilsho	4479	8	of	of	IN
cord-006229-7yoilsho	4479	9	adenosine	adenosine	NN
cord-006229-7yoilsho	4479	10	A2A	a2a	NN
cord-006229-7yoilsho	4479	11	receptors	receptor	NNS
cord-006229-7yoilsho	4479	12	(	(	-LRB-
cord-006229-7yoilsho	4479	13	A2AR	a2ar	NN
cord-006229-7yoilsho	4479	14	)	)	-RRB-
cord-006229-7yoilsho	4479	15	and	and	CC
cord-006229-7yoilsho	4479	16	adenosine	adenosine	NN
cord-006229-7yoilsho	4479	17	A2B	A2B	NNP
cord-006229-7yoilsho	4479	18	receptors	receptor	NNS
cord-006229-7yoilsho	4479	19	(	(	-LRB-
cord-006229-7yoilsho	4479	20	A2BR	A2BR	NNP
cord-006229-7yoilsho	4479	21	)	)	-RRB-
cord-006229-7yoilsho	4479	22	to	to	TO
cord-006229-7yoilsho	4479	23	regulate	regulate	VB
cord-006229-7yoilsho	4479	24	contractility	contractility	NN
cord-006229-7yoilsho	4479	25	in	in	IN
cord-006229-7yoilsho	4479	26	untreated	untreated	JJ
cord-006229-7yoilsho	4479	27	and	and	CC
cord-006229-7yoilsho	4479	28	inflamed	inflamed	JJ
cord-006229-7yoilsho	4479	29	rat	rat	NN
cord-006229-7yoilsho	4479	30	colon	colon	NN
cord-006229-7yoilsho	4479	31	preparations	preparation	NNS
cord-006229-7yoilsho	4479	32	using	use	VBG
cord-006229-7yoilsho	4479	33	a	a	DT
cord-006229-7yoilsho	4479	34	specific	specific	JJ
cord-006229-7yoilsho	4479	35	A2AR	a2ar	NN
cord-006229-7yoilsho	4479	36	agonist	agonist	NN
cord-006229-7yoilsho	4479	37	(	(	-LRB-
cord-006229-7yoilsho	4479	38	CGS	CGS	NNP
cord-006229-7yoilsho	4479	39	21680	21680	CD
cord-006229-7yoilsho	4479	40	)	)	-RRB-
cord-006229-7yoilsho	4479	41	and	and	CC
cord-006229-7yoilsho	4479	42	an	an	DT
cord-006229-7yoilsho	4479	43	A2BR	A2BR	NNP
cord-006229-7yoilsho	4479	44	antagonist	antagonist	NN
cord-006229-7yoilsho	4479	45	(	(	-LRB-
cord-006229-7yoilsho	4479	46	PSB-1115	PSB-1115	NNP
cord-006229-7yoilsho	4479	47	)	)	-RRB-
cord-006229-7yoilsho	4479	48	on	on	IN
cord-006229-7yoilsho	4479	49	acute	acute	JJ
cord-006229-7yoilsho	4479	50	inflammation	inflammation	NN
cord-006229-7yoilsho	4479	51	in	in	IN
cord-006229-7yoilsho	4479	52	rat	rat	NN
cord-006229-7yoilsho	4479	53	colon	colon	NN
cord-006229-7yoilsho	4479	54	preparations	preparation	NNS
cord-006229-7yoilsho	4479	55	.	.	.
cord-006229-7yoilsho	4480	1	Further	further	RB
cord-006229-7yoilsho	4480	2	it	-PRON-	PRP
cord-006229-7yoilsho	4480	3	focused	focus	VBD
cord-006229-7yoilsho	4480	4	on	on	IN
cord-006229-7yoilsho	4480	5	interactions	interaction	NNS
cord-006229-7yoilsho	4480	6	of	of	IN
cord-006229-7yoilsho	4480	7	the	the	DT
cord-006229-7yoilsho	4480	8	multi	multi	JJ
cord-006229-7yoilsho	4480	9	-	-	JJ
cord-006229-7yoilsho	4480	10	herbal	herbal	JJ
cord-006229-7yoilsho	4480	11	drug	drug	NN
cord-006229-7yoilsho	4480	12	STW	STW	NNP
cord-006229-7yoilsho	4480	13	5	5	CD
cord-006229-7yoilsho	4480	14	with	with	IN
cord-006229-7yoilsho	4480	15	A2AR	A2AR	NNP
cord-006229-7yoilsho	4480	16	as	as	IN
cord-006229-7yoilsho	4480	17	a	a	DT
cord-006229-7yoilsho	4480	18	possible	possible	JJ
cord-006229-7yoilsho	4480	19	mechanism	mechanism	NN
cord-006229-7yoilsho	4480	20	of	of	IN
cord-006229-7yoilsho	4480	21	the	the	DT
cord-006229-7yoilsho	4480	22	protective	protective	JJ
cord-006229-7yoilsho	4480	23	effect	effect	NN
cord-006229-7yoilsho	4480	24	of	of	IN
cord-006229-7yoilsho	4480	25	STW	STW	NNP
cord-006229-7yoilsho	4480	26	5	5	CD
cord-006229-7yoilsho	4480	27	in	in	IN
cord-006229-7yoilsho	4480	28	gastrointestinal	gastrointestinal	JJ
cord-006229-7yoilsho	4480	29	disorders	disorder	NNS
cord-006229-7yoilsho	4480	30	.	.	.
cord-006229-7yoilsho	4481	1	Methods	method	NNS
cord-006229-7yoilsho	4481	2	:	:	:
cord-006229-7yoilsho	4481	3	Inflammation	inflammation	NN
cord-006229-7yoilsho	4481	4	was	be	VBD
cord-006229-7yoilsho	4481	5	induced	induce	VBN
cord-006229-7yoilsho	4481	6	by	by	IN
cord-006229-7yoilsho	4481	7	intraluminal	intraluminal	JJ
cord-006229-7yoilsho	4481	8	instillation	instillation	NN
cord-006229-7yoilsho	4481	9	of	of	IN
cord-006229-7yoilsho	4481	10	2,4,6-trinitrobenzene	2,4,6-trinitrobenzene	CD
cord-006229-7yoilsho	4481	11	sulfonic	sulfonic	JJ
cord-006229-7yoilsho	4481	12	acid	acid	NN
cord-006229-7yoilsho	4481	13	(	(	-LRB-
cord-006229-7yoilsho	4481	14	TNBS	TNBS	NNP
cord-006229-7yoilsho	4481	15	)	)	-RRB-
cord-006229-7yoilsho	4481	16	.	.	.
cord-006229-7yoilsho	4482	1	Contractions	contraction	NNS
cord-006229-7yoilsho	4482	2	were	be	VBD
cord-006229-7yoilsho	4482	3	measured	measure	VBN
cord-006229-7yoilsho	4482	4	isometrically	isometrically	RB
cord-006229-7yoilsho	4482	5	in	in	IN
cord-006229-7yoilsho	4482	6	an	an	DT
cord-006229-7yoilsho	4482	7	organ	organ	NN
cord-006229-7yoilsho	4482	8	bath	bath	NN
cord-006229-7yoilsho	4482	9	set	set	VBN
cord-006229-7yoilsho	4482	10	up	up	RP
cord-006229-7yoilsho	4482	11	.	.	.
cord-006229-7yoilsho	4483	1	Gene	gene	NN
cord-006229-7yoilsho	4483	2	expression	expression	NN
cord-006229-7yoilsho	4483	3	was	be	VBD
cord-006229-7yoilsho	4483	4	determined	determine	VBN
cord-006229-7yoilsho	4483	5	using	use	VBG
cord-006229-7yoilsho	4483	6	RT	RT	NNP
cord-006229-7yoilsho	4483	7	-	-	HYPH
cord-006229-7yoilsho	4483	8	PCR	PCR	NNP
cord-006229-7yoilsho	4483	9	.	.	.
cord-006229-7yoilsho	4484	1	Radio	radio	NN
cord-006229-7yoilsho	4484	2	ligand	ligand	NN
cord-006229-7yoilsho	4484	3	binding	bind	VBG
cord-006229-7yoilsho	4484	4	assays	assay	NNS
cord-006229-7yoilsho	4484	5	(	(	-LRB-
cord-006229-7yoilsho	4484	6	competition	competition	NN
cord-006229-7yoilsho	4484	7	experiments	experiment	NNS
cord-006229-7yoilsho	4484	8	)	)	-RRB-
cord-006229-7yoilsho	4484	9	were	be	VBD
cord-006229-7yoilsho	4484	10	carried	carry	VBN
cord-006229-7yoilsho	4484	11	out	out	RP
cord-006229-7yoilsho	4484	12	with	with	IN
cord-006229-7yoilsho	4484	13	rat	rat	NN
cord-006229-7yoilsho	4484	14	brain	brain	NN
cord-006229-7yoilsho	4484	15	homogenates	homogenate	NNS
cord-006229-7yoilsho	4484	16	.	.	.
cord-006229-7yoilsho	4485	1	Morphological	morphological	JJ
cord-006229-7yoilsho	4485	2	changes	change	NNS
cord-006229-7yoilsho	4485	3	were	be	VBD
cord-006229-7yoilsho	4485	4	estimated	estimate	VBN
cord-006229-7yoilsho	4485	5	after	after	IN
cord-006229-7yoilsho	4485	6	van	van	NNP
cord-006229-7yoilsho	4485	7	Gieson	Gieson	NNP
cord-006229-7yoilsho	4485	8	staining	stain	VBG
cord-006229-7yoilsho	4485	9	.	.	.
cord-006229-7yoilsho	4486	1	Results	result	NNS
cord-006229-7yoilsho	4486	2	:	:	:
cord-006229-7yoilsho	4487	1	All	all	DT
cord-006229-7yoilsho	4487	2	four	four	CD
cord-006229-7yoilsho	4487	3	adenosine	adenosine	NN
cord-006229-7yoilsho	4487	4	receptor	receptor	NN
cord-006229-7yoilsho	4487	5	subtypes	subtype	NNS
cord-006229-7yoilsho	4487	6	were	be	VBD
cord-006229-7yoilsho	4487	7	expressed	express	VBN
cord-006229-7yoilsho	4487	8	in	in	IN
cord-006229-7yoilsho	4487	9	untreated	untreated	JJ
cord-006229-7yoilsho	4487	10	colon	colon	NN
cord-006229-7yoilsho	4487	11	preparations	preparation	NNS
cord-006229-7yoilsho	4487	12	.	.	.
cord-006229-7yoilsho	4488	1	Activation	activation	NN
cord-006229-7yoilsho	4488	2	of	of	IN
cord-006229-7yoilsho	4488	3	A1	A1	NNP
cord-006229-7yoilsho	4488	4	,	,	,
cord-006229-7yoilsho	4488	5	A2B	A2B	NNP
cord-006229-7yoilsho	4488	6	,	,	,
cord-006229-7yoilsho	4488	7	and	and	CC
cord-006229-7yoilsho	4488	8	A3	A3	NNP
cord-006229-7yoilsho	4488	9	receptor	receptor	NN
cord-006229-7yoilsho	4488	10	with	with	IN
cord-006229-7yoilsho	4488	11	specific	specific	JJ
cord-006229-7yoilsho	4488	12	agonists	agonist	NNS
cord-006229-7yoilsho	4488	13	reduced	reduce	VBD
cord-006229-7yoilsho	4488	14	the	the	DT
cord-006229-7yoilsho	4488	15	acetylcholine	acetylcholine	NN
cord-006229-7yoilsho	4488	16	(	(	-LRB-
cord-006229-7yoilsho	4488	17	ACh	ACh	NNP
cord-006229-7yoilsho	4488	18	,	,	,
cord-006229-7yoilsho	4488	19	10µM)-induced	10µm)-induced	CD
cord-006229-7yoilsho	4488	20	contractions	contraction	NNS
cord-006229-7yoilsho	4488	21	,	,	,
cord-006229-7yoilsho	4488	22	while	while	IN
cord-006229-7yoilsho	4488	23	activation	activation	NN
cord-006229-7yoilsho	4488	24	of	of	IN
cord-006229-7yoilsho	4488	25	A2BR	A2BR	NNP
cord-006229-7yoilsho	4488	26	enhanced	enhance	VBD
cord-006229-7yoilsho	4488	27	it	-PRON-	PRP
cord-006229-7yoilsho	4488	28	.	.	.
cord-006229-7yoilsho	4489	1	After	after	IN
cord-006229-7yoilsho	4489	2	incubation	incubation	NN
cord-006229-7yoilsho	4489	3	with	with	IN
cord-006229-7yoilsho	4489	4	TNBS	TNBS	NNP
cord-006229-7yoilsho	4489	5	morphological	morphological	JJ
cord-006229-7yoilsho	4489	6	damages	damage	NNS
cord-006229-7yoilsho	4489	7	in	in	IN
cord-006229-7yoilsho	4489	8	colonic	colonic	JJ
cord-006229-7yoilsho	4489	9	mucosa	mucosa	NN
cord-006229-7yoilsho	4489	10	and	and	CC
cord-006229-7yoilsho	4489	11	muscle	muscle	NN
cord-006229-7yoilsho	4489	12	walls	wall	NNS
cord-006229-7yoilsho	4489	13	were	be	VBD
cord-006229-7yoilsho	4489	14	detectable	detectable	JJ
cord-006229-7yoilsho	4489	15	followed	follow	VBN
cord-006229-7yoilsho	4489	16	by	by	IN
cord-006229-7yoilsho	4489	17	reduced	reduce	VBN
cord-006229-7yoilsho	4489	18	ACh	ACh	NNP
cord-006229-7yoilsho	4489	19	-	-	HYPH
cord-006229-7yoilsho	4489	20	contractions	contraction	NNS
cord-006229-7yoilsho	4489	21	.	.	.
cord-006229-7yoilsho	4490	1	The	the	DT
cord-006229-7yoilsho	4490	2	TNBS	TNBS	NNP
cord-006229-7yoilsho	4490	3	-	-	HYPH
cord-006229-7yoilsho	4490	4	mediated	mediate	VBN
cord-006229-7yoilsho	4490	5	decrease	decrease	NN
cord-006229-7yoilsho	4490	6	of	of	IN
cord-006229-7yoilsho	4490	7	ACh	ACh	NNP
cord-006229-7yoilsho	4490	8	-	-	HYPH
cord-006229-7yoilsho	4490	9	contractions	contraction	NNS
cord-006229-7yoilsho	4490	10	as	as	RB
cord-006229-7yoilsho	4490	11	well	well	RB
cord-006229-7yoilsho	4490	12	as	as	IN
cord-006229-7yoilsho	4490	13	the	the	DT
cord-006229-7yoilsho	4490	14	morphological	morphological	JJ
cord-006229-7yoilsho	4490	15	damages	damage	NNS
cord-006229-7yoilsho	4490	16	were	be	VBD
cord-006229-7yoilsho	4490	17	partially	partially	RB
cord-006229-7yoilsho	4490	18	normalized	normalize	VBN
cord-006229-7yoilsho	4490	19	by	by	IN
cord-006229-7yoilsho	4490	20	co	co	NN
cord-006229-7yoilsho	4490	21	-	-	NN
cord-006229-7yoilsho	4490	22	incubation	incubation	NN
cord-006229-7yoilsho	4490	23	of	of	IN
cord-006229-7yoilsho	4490	24	TNBS	TNBS	NNP
cord-006229-7yoilsho	4490	25	with	with	IN
cord-006229-7yoilsho	4490	26	CGS	CGS	NNP
cord-006229-7yoilsho	4490	27	21680	21680	CD
cord-006229-7yoilsho	4490	28	(	(	-LRB-
cord-006229-7yoilsho	4490	29	10µM	10µm	CD
cord-006229-7yoilsho	4490	30	)	)	-RRB-
cord-006229-7yoilsho	4490	31	or	or	CC
cord-006229-7yoilsho	4490	32	with	with	IN
cord-006229-7yoilsho	4490	33	PSB	PSB	NNP
cord-006229-7yoilsho	4490	34	1115	1115	CD
cord-006229-7yoilsho	4490	35	(	(	-LRB-
cord-006229-7yoilsho	4490	36	100µM	100µm	NN
cord-006229-7yoilsho	4490	37	)	)	-RRB-
cord-006229-7yoilsho	4490	38	.	.	.
cord-006229-7yoilsho	4491	1	The	the	DT
cord-006229-7yoilsho	4491	2	same	same	JJ
cord-006229-7yoilsho	4491	3	effects	effect	NNS
cord-006229-7yoilsho	4491	4	with	with	IN
cord-006229-7yoilsho	4491	5	smaller	small	JJR
cord-006229-7yoilsho	4491	6	intensity	intensity	NN
cord-006229-7yoilsho	4491	7	were	be	VBD
cord-006229-7yoilsho	4491	8	found	find	VBN
cord-006229-7yoilsho	4491	9	for	for	IN
cord-006229-7yoilsho	4491	10	STW	STW	NNP
cord-006229-7yoilsho	4491	11	5	5	CD
cord-006229-7yoilsho	4491	12	(	(	-LRB-
cord-006229-7yoilsho	4491	13	512	512	CD
cord-006229-7yoilsho	4491	14	µg	µg	NN
cord-006229-7yoilsho	4491	15	/	/	SYM
cord-006229-7yoilsho	4491	16	ml	ml	NN
cord-006229-7yoilsho	4491	17	)	)	-RRB-
cord-006229-7yoilsho	4491	18	in	in	IN
cord-006229-7yoilsho	4491	19	female	female	NN
cord-006229-7yoilsho	4491	20	but	but	CC
cord-006229-7yoilsho	4491	21	not	not	RB
cord-006229-7yoilsho	4491	22	in	in	IN
cord-006229-7yoilsho	4491	23	male	male	JJ
cord-006229-7yoilsho	4491	24	colon	colon	NN
cord-006229-7yoilsho	4491	25	preparations	preparation	NNS
cord-006229-7yoilsho	4491	26	.	.	.
cord-006229-7yoilsho	4492	1	These	these	DT
cord-006229-7yoilsho	4492	2	results	result	NNS
cord-006229-7yoilsho	4492	3	are	be	VBP
cord-006229-7yoilsho	4492	4	in	in	IN
cord-006229-7yoilsho	4492	5	accordance	accordance	NN
cord-006229-7yoilsho	4492	6	with	with	IN
cord-006229-7yoilsho	4492	7	ligand	ligand	NN
cord-006229-7yoilsho	4492	8	binding	binding	NN
cord-006229-7yoilsho	4492	9	studies	study	NNS
cord-006229-7yoilsho	4492	10	indicating	indicate	VBG
cord-006229-7yoilsho	4492	11	that	that	IN
cord-006229-7yoilsho	4492	12	STW	STW	NNP
cord-006229-7yoilsho	4492	13	5	5	CD
cord-006229-7yoilsho	4492	14	interact	interact	VBP
cord-006229-7yoilsho	4492	15	with	with	IN
cord-006229-7yoilsho	4492	16	the	the	DT
cord-006229-7yoilsho	4492	17	A2AR	A2AR	NNP
cord-006229-7yoilsho	4492	18	.	.	.
cord-006229-7yoilsho	4493	1	Conclusion	conclusion	NN
cord-006229-7yoilsho	4493	2	:	:	:
cord-006229-7yoilsho	4494	1	Anti	anti	JJ
cord-006229-7yoilsho	4494	2	-	-	JJ
cord-006229-7yoilsho	4494	3	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	4494	4	mechanisms	mechanism	NNS
cord-006229-7yoilsho	4494	5	and	and	CC
cord-006229-7yoilsho	4494	6	cell	cell	NN
cord-006229-7yoilsho	4494	7	protective	protective	JJ
cord-006229-7yoilsho	4494	8	actions	action	NNS
cord-006229-7yoilsho	4494	9	of	of	IN
cord-006229-7yoilsho	4494	10	STW	STW	NNP
cord-006229-7yoilsho	4494	11	5	5	CD
cord-006229-7yoilsho	4494	12	are	be	VBP
cord-006229-7yoilsho	4494	13	partly	partly	RB
cord-006229-7yoilsho	4494	14	due	due	JJ
cord-006229-7yoilsho	4494	15	to	to	IN
cord-006229-7yoilsho	4494	16	the	the	DT
cord-006229-7yoilsho	4494	17	interaction	interaction	NN
cord-006229-7yoilsho	4494	18	with	with	IN
cord-006229-7yoilsho	4494	19	adenosine	adenosine	NN
cord-006229-7yoilsho	4494	20	receptors	receptor	NNS
cord-006229-7yoilsho	4494	21	.	.	.
cord-006229-7yoilsho	4495	1	The	the	DT
cord-006229-7yoilsho	4495	2	results	result	NNS
cord-006229-7yoilsho	4495	3	give	give	VBP
cord-006229-7yoilsho	4495	4	a	a	DT
cord-006229-7yoilsho	4495	5	clear	clear	RB
cord-006229-7yoilsho	4495	6	-	-	HYPH
cord-006229-7yoilsho	4495	7	cut	cut	VBN
cord-006229-7yoilsho	4495	8	correlation	correlation	NN
cord-006229-7yoilsho	4495	9	with	with	IN
cord-006229-7yoilsho	4495	10	symptom	symptom	NN
cord-006229-7yoilsho	4495	11	improvements	improvement	NNS
cord-006229-7yoilsho	4495	12	in	in	IN
cord-006229-7yoilsho	4495	13	clinical	clinical	JJ
cord-006229-7yoilsho	4495	14	trials	trial	NNS
cord-006229-7yoilsho	4495	15	and	and	CC
cord-006229-7yoilsho	4495	16	thereby	thereby	RB
cord-006229-7yoilsho	4495	17	highlight	highlight	VB
cord-006229-7yoilsho	4495	18	the	the	DT
cord-006229-7yoilsho	4495	19	relevance	relevance	NN
cord-006229-7yoilsho	4495	20	of	of	IN
cord-006229-7yoilsho	4495	21	STW	STW	NNP
cord-006229-7yoilsho	4495	22	5	5	CD
cord-006229-7yoilsho	4495	23	as	as	IN
cord-006229-7yoilsho	4495	24	a	a	DT
cord-006229-7yoilsho	4495	25	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	4495	26	approach	approach	NN
cord-006229-7yoilsho	4495	27	in	in	IN
cord-006229-7yoilsho	4495	28	IBS	IBS	NNP
cord-006229-7yoilsho	4495	29	.	.	.
cord-006229-7yoilsho	4496	1	(	(	-LRB-
cord-006229-7yoilsho	4496	2	Allescher	Allescher	NNP
cord-006229-7yoilsho	4496	3	2006	2006	CD
cord-006229-7yoilsho	4496	4	)	)	-RRB-
cord-006229-7yoilsho	4496	5	.	.	.
cord-006229-7yoilsho	4497	1	Therefore	therefore	RB
cord-006229-7yoilsho	4497	2	,	,	,
cord-006229-7yoilsho	4497	3	a	a	DT
cord-006229-7yoilsho	4497	4	multi	multi	JJ
cord-006229-7yoilsho	4497	5	-	-	JJ
cord-006229-7yoilsho	4497	6	target	target	JJ
cord-006229-7yoilsho	4497	7	approach	approach	NN
cord-006229-7yoilsho	4497	8	is	be	VBZ
cord-006229-7yoilsho	4497	9	a	a	DT
cord-006229-7yoilsho	4497	10	promising	promising	JJ
cord-006229-7yoilsho	4497	11	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	4497	12	strategy	strategy	NN
cord-006229-7yoilsho	4497	13	,	,	,
cord-006229-7yoilsho	4497	14	as	as	IN
cord-006229-7yoilsho	4497	15	is	be	VBZ
cord-006229-7yoilsho	4497	16	exemplified	exemplify	VBN
cord-006229-7yoilsho	4497	17	by	by	IN
cord-006229-7yoilsho	4497	18	STW	STW	NNP
cord-006229-7yoilsho	4497	19	5(Ottillinger	5(ottillinger	CD
cord-006229-7yoilsho	4498	1	et	et	NNP
cord-006229-7yoilsho	4498	2	al	al	NNP
cord-006229-7yoilsho	4498	3	.	.	NNP
cord-006229-7yoilsho	4498	4	2013	2013	CD
cord-006229-7yoilsho	4498	5	)	)	-RRB-
cord-006229-7yoilsho	4498	6	.	.	.
cord-006229-7yoilsho	4499	1	STW	STW	NNP
cord-006229-7yoilsho	4499	2	5	5	CD
cord-006229-7yoilsho	4500	1	(	(	-LRB-
cord-006229-7yoilsho	4500	2	Iberogast	Iberogast	NNP
cord-006229-7yoilsho	4500	3	®	®	,
cord-006229-7yoilsho	4500	4	)	)	-RRB-
cord-006229-7yoilsho	4500	5	is	be	VBZ
cord-006229-7yoilsho	4500	6	a	a	DT
cord-006229-7yoilsho	4500	7	fixed	fix	VBN
cord-006229-7yoilsho	4500	8	combination	combination	NN
cord-006229-7yoilsho	4500	9	of	of	IN
cord-006229-7yoilsho	4500	10	nine	nine	CD
cord-006229-7yoilsho	4500	11	plant	plant	NN
cord-006229-7yoilsho	4500	12	extracts	extract	NNS
cord-006229-7yoilsho	4500	13	with	with	IN
cord-006229-7yoilsho	4500	14	Iberis	Iberis	NNP
cord-006229-7yoilsho	4500	15	amara	amara	NNP
cord-006229-7yoilsho	4500	16	(	(	-LRB-
cord-006229-7yoilsho	4500	17	STW	STW	NNP
cord-006229-7yoilsho	4500	18	6	6	CD
cord-006229-7yoilsho	4500	19	)	)	-RRB-
cord-006229-7yoilsho	4500	20	as	as	IN
cord-006229-7yoilsho	4500	21	one	one	CD
cord-006229-7yoilsho	4500	22	of	of	IN
cord-006229-7yoilsho	4500	23	its	-PRON-	PRP$
cord-006229-7yoilsho	4500	24	components	component	NNS
cord-006229-7yoilsho	4500	25	.	.	.
cord-006229-7yoilsho	4501	1	It	-PRON-	PRP
cord-006229-7yoilsho	4501	2	is	be	VBZ
cord-006229-7yoilsho	4501	3	successfully	successfully	RB
cord-006229-7yoilsho	4501	4	used	use	VBN
cord-006229-7yoilsho	4501	5	for	for	IN
cord-006229-7yoilsho	4501	6	treatment	treatment	NN
cord-006229-7yoilsho	4501	7	of	of	IN
cord-006229-7yoilsho	4501	8	functional	functional	JJ
cord-006229-7yoilsho	4501	9	dyspepsia	dyspepsia	NN
cord-006229-7yoilsho	4501	10	and	and	CC
cord-006229-7yoilsho	4501	11	irritable	irritable	JJ
cord-006229-7yoilsho	4501	12	bowel	bowel	NN
cord-006229-7yoilsho	4501	13	syndrome	syndrome	NN
cord-006229-7yoilsho	4501	14	(	(	-LRB-
cord-006229-7yoilsho	4501	15	IBS	IBS	NNP
cord-006229-7yoilsho	4501	16	)	)	-RRB-
cord-006229-7yoilsho	4501	17	.	.	.
cord-006229-7yoilsho	4502	1	To	to	TO
cord-006229-7yoilsho	4502	2	allow	allow	VB
cord-006229-7yoilsho	4502	3	an	an	DT
cord-006229-7yoilsho	4502	4	overview	overview	NN
cord-006229-7yoilsho	4502	5	of	of	IN
cord-006229-7yoilsho	4502	6	targets	target	NNS
cord-006229-7yoilsho	4502	7	addressed	address	VBN
cord-006229-7yoilsho	4502	8	by	by	IN
cord-006229-7yoilsho	4502	9	STW	STW	NNP
cord-006229-7yoilsho	4502	10	5	5	CD
cord-006229-7yoilsho	4502	11	and	and	CC
cord-006229-7yoilsho	4502	12	the	the	DT
cord-006229-7yoilsho	4502	13	role	role	NN
cord-006229-7yoilsho	4502	14	of	of	IN
cord-006229-7yoilsho	4502	15	its	-PRON-	PRP$
cord-006229-7yoilsho	4502	16	components	component	NNS
cord-006229-7yoilsho	4502	17	in	in	IN
cord-006229-7yoilsho	4502	18	relation	relation	NN
cord-006229-7yoilsho	4502	19	to	to	IN
cord-006229-7yoilsho	4502	20	the	the	DT
cord-006229-7yoilsho	4502	21	different	different	JJ
cord-006229-7yoilsho	4502	22	forms	form	NNS
cord-006229-7yoilsho	4502	23	and	and	CC
cord-006229-7yoilsho	4502	24	causes	cause	NNS
cord-006229-7yoilsho	4502	25	of	of	IN
cord-006229-7yoilsho	4502	26	functional	functional	JJ
cord-006229-7yoilsho	4502	27	GI	GI	NNP
cord-006229-7yoilsho	4502	28	diseases	disease	NNS
cord-006229-7yoilsho	4502	29	,	,	,
cord-006229-7yoilsho	4502	30	an	an	DT
cord-006229-7yoilsho	4502	31	evaluation	evaluation	NN
cord-006229-7yoilsho	4502	32	of	of	IN
cord-006229-7yoilsho	4502	33	the	the	DT
cord-006229-7yoilsho	4502	34	data	datum	NNS
cord-006229-7yoilsho	4502	35	,	,	,
cord-006229-7yoilsho	4502	36	which	which	WDT
cord-006229-7yoilsho	4502	37	have	have	VBP
cord-006229-7yoilsho	4502	38	been	be	VBN
cord-006229-7yoilsho	4502	39	gained	gain	VBN
cord-006229-7yoilsho	4502	40	from	from	IN
cord-006229-7yoilsho	4502	41	more	more	JJR
cord-006229-7yoilsho	4502	42	than	than	IN
cord-006229-7yoilsho	4502	43	150	150	CD
cord-006229-7yoilsho	4502	44	pharmacological	pharmacological	JJ
cord-006229-7yoilsho	4502	45	tests	test	NNS
cord-006229-7yoilsho	4502	46	,	,	,
cord-006229-7yoilsho	4502	47	is	be	VBZ
cord-006229-7yoilsho	4502	48	needed	need	VBN
cord-006229-7yoilsho	4502	49	.	.	.
cord-006229-7yoilsho	4503	1	All	all	DT
cord-006229-7yoilsho	4503	2	data	datum	NNS
cord-006229-7yoilsho	4503	3	from	from	IN
cord-006229-7yoilsho	4503	4	studies	study	NNS
cord-006229-7yoilsho	4503	5	including	include	VBG
cord-006229-7yoilsho	4503	6	STW	STW	NNP
cord-006229-7yoilsho	4503	7	5	5	CD
cord-006229-7yoilsho	4503	8	alone	alone	RB
cord-006229-7yoilsho	4503	9	,	,	,
cord-006229-7yoilsho	4503	10	or	or	CC
cord-006229-7yoilsho	4503	11	STW	STW	NNP
cord-006229-7yoilsho	4503	12	5	5	CD
cord-006229-7yoilsho	4503	13	and	and	CC
cord-006229-7yoilsho	4503	14	its	-PRON-	PRP$
cord-006229-7yoilsho	4503	15	components	component	NNS
cord-006229-7yoilsho	4503	16	,	,	,
cord-006229-7yoilsho	4503	17	were	be	VBD
cord-006229-7yoilsho	4503	18	retrieved	retrieve	VBN
cord-006229-7yoilsho	4503	19	and	and	CC
cord-006229-7yoilsho	4503	20	sorted	sort	VBN
cord-006229-7yoilsho	4503	21	according	accord	VBG
cord-006229-7yoilsho	4503	22	to	to	IN
cord-006229-7yoilsho	4503	23	types	type	NNS
cord-006229-7yoilsho	4503	24	of	of	IN
cord-006229-7yoilsho	4503	25	study	study	NN
cord-006229-7yoilsho	4503	26	models	model	NNS
cord-006229-7yoilsho	4503	27	(	(	-LRB-
cord-006229-7yoilsho	4503	28	Human	human	JJ
cord-006229-7yoilsho	4503	29	and	and	CC
cord-006229-7yoilsho	4503	30	animal	animal	NN
cord-006229-7yoilsho	4503	31	systems	system	NNS
cord-006229-7yoilsho	4503	32	,	,	,
cord-006229-7yoilsho	4503	33	animal	animal	NN
cord-006229-7yoilsho	4503	34	disease	disease	NN
cord-006229-7yoilsho	4503	35	models	model	NNS
cord-006229-7yoilsho	4503	36	,	,	,
cord-006229-7yoilsho	4503	37	GI	GI	NNP
cord-006229-7yoilsho	4503	38	-	-	HYPH
cord-006229-7yoilsho	4503	39	preparations	preparation	NNS
cord-006229-7yoilsho	4503	40	,	,	,
cord-006229-7yoilsho	4503	41	cell	cell	NN
cord-006229-7yoilsho	4503	42	cultures	culture	NNS
cord-006229-7yoilsho	4503	43	,	,	,
cord-006229-7yoilsho	4503	44	in	in	IN
cord-006229-7yoilsho	4503	45	vitro	vitro	FW
cord-006229-7yoilsho	4503	46	-	-	HYPH
cord-006229-7yoilsho	4503	47	systems	system	NNS
cord-006229-7yoilsho	4503	48	)	)	-RRB-
cord-006229-7yoilsho	4503	49	and	and	CC
cord-006229-7yoilsho	4503	50	respective	respective	JJ
cord-006229-7yoilsho	4503	51	etiologic	etiologic	NN
cord-006229-7yoilsho	4503	52	mechanisms	mechanism	NNS
cord-006229-7yoilsho	4503	53	related	relate	VBN
cord-006229-7yoilsho	4503	54	to	to	IN
cord-006229-7yoilsho	4503	55	FGDs	fgd	NNS
cord-006229-7yoilsho	4503	56	and	and	CC
cord-006229-7yoilsho	4503	57	then	then	RB
cord-006229-7yoilsho	4503	58	visualized	visualize	VBN
cord-006229-7yoilsho	4503	59	in	in	IN
cord-006229-7yoilsho	4503	60	the	the	DT
cord-006229-7yoilsho	4503	61	form	form	NN
cord-006229-7yoilsho	4503	62	of	of	IN
cord-006229-7yoilsho	4503	63	2D	2d	NN
cord-006229-7yoilsho	4503	64	histograms	histogram	NNS
cord-006229-7yoilsho	4503	65	(	(	-LRB-
cord-006229-7yoilsho	4503	66	Lorkowski	Lorkowski	NNP
cord-006229-7yoilsho	4503	67	et	et	FW
cord-006229-7yoilsho	4503	68	al	al	NNP
cord-006229-7yoilsho	4503	69	.	.	NNP
cord-006229-7yoilsho	4503	70	2015	2015	CD
cord-006229-7yoilsho	4503	71	)	)	-RRB-
cord-006229-7yoilsho	4503	72	.	.	.
cord-006229-7yoilsho	4504	1	Results	result	NNS
cord-006229-7yoilsho	4504	2	:	:	:
cord-006229-7yoilsho	4504	3	More	More	JJR
cord-006229-7yoilsho	4504	4	than	than	IN
cord-006229-7yoilsho	4504	5	150	150	CD
cord-006229-7yoilsho	4504	6	pharmacological	pharmacological	JJ
cord-006229-7yoilsho	4504	7	tests	test	NNS
cord-006229-7yoilsho	4504	8	indicated	indicate	VBD
cord-006229-7yoilsho	4504	9	anti	anti	JJ
cord-006229-7yoilsho	4504	10	-	-	JJ
cord-006229-7yoilsho	4504	11	oxidative	oxidative	JJ
cord-006229-7yoilsho	4504	12	activity	activity	NN
cord-006229-7yoilsho	4504	13	,	,	,
cord-006229-7yoilsho	4504	14	electrophysiological	electrophysiological	JJ
cord-006229-7yoilsho	4504	15	effects	effect	NNS
cord-006229-7yoilsho	4504	16	,	,	,
cord-006229-7yoilsho	4504	17	ulcer	ulcer	NN
cord-006229-7yoilsho	4504	18	protection	protection	NN
cord-006229-7yoilsho	4504	19	,	,	,
cord-006229-7yoilsho	4504	20	anti	anti	JJ
cord-006229-7yoilsho	4504	21	-	-	JJ
cord-006229-7yoilsho	4504	22	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	4504	23	actions	action	NNS
cord-006229-7yoilsho	4504	24	,	,	,
cord-006229-7yoilsho	4504	25	pro	pro	JJ
cord-006229-7yoilsho	4504	26	-	-	JJ
cord-006229-7yoilsho	4504	27	kinetic	kinetic	JJ
cord-006229-7yoilsho	4504	28	and	and	CC
cord-006229-7yoilsho	4504	29	spasmolytic	spasmolytic	JJ
cord-006229-7yoilsho	4504	30	effects	effect	NNS
cord-006229-7yoilsho	4504	31	as	as	RB
cord-006229-7yoilsho	4504	32	well	well	RB
cord-006229-7yoilsho	4504	33	as	as	IN
cord-006229-7yoilsho	4504	34	reflux	reflux	NN
cord-006229-7yoilsho	4504	35	and	and	CC
cord-006229-7yoilsho	4504	36	acid	acid	NN
cord-006229-7yoilsho	4504	37	reduction	reduction	NN
cord-006229-7yoilsho	4504	38	.	.	.
cord-006229-7yoilsho	4505	1	Moreover	moreover	RB
cord-006229-7yoilsho	4505	2	,	,	,
cord-006229-7yoilsho	4505	3	the	the	DT
cord-006229-7yoilsho	4505	4	analysis	analysis	NN
cord-006229-7yoilsho	4505	5	indicated	indicate	VBD
cord-006229-7yoilsho	4505	6	that	that	IN
cord-006229-7yoilsho	4505	7	the	the	DT
cord-006229-7yoilsho	4505	8	components	component	NNS
cord-006229-7yoilsho	4505	9	of	of	IN
cord-006229-7yoilsho	4505	10	STW	STW	NNP
cord-006229-7yoilsho	4505	11	5	5	CD
cord-006229-7yoilsho	4505	12	contribute	contribute	VBP
cord-006229-7yoilsho	4505	13	differently	differently	RB
cord-006229-7yoilsho	4505	14	to	to	IN
cord-006229-7yoilsho	4505	15	the	the	DT
cord-006229-7yoilsho	4505	16	overall	overall	JJ
cord-006229-7yoilsho	4505	17	effect	effect	NN
cord-006229-7yoilsho	4505	18	of	of	IN
cord-006229-7yoilsho	4505	19	STW	STW	NNP
cord-006229-7yoilsho	4505	20	5	5	CD
cord-006229-7yoilsho	4505	21	.	.	.
cord-006229-7yoilsho	4506	1	Altogether	altogether	RB
cord-006229-7yoilsho	4506	2	,	,	,
cord-006229-7yoilsho	4506	3	the	the	DT
cord-006229-7yoilsho	4506	4	evaluation	evaluation	NN
cord-006229-7yoilsho	4506	5	of	of	IN
cord-006229-7yoilsho	4506	6	the	the	DT
cord-006229-7yoilsho	4506	7	data	datum	NNS
cord-006229-7yoilsho	4506	8	shows	show	VBZ
cord-006229-7yoilsho	4506	9	that	that	IN
cord-006229-7yoilsho	4506	10	STW	STW	NNP
cord-006229-7yoilsho	4506	11	5	5	CD
cord-006229-7yoilsho	4506	12	is	be	VBZ
cord-006229-7yoilsho	4506	13	active	active	JJ
cord-006229-7yoilsho	4506	14	in	in	IN
cord-006229-7yoilsho	4506	15	response	response	NN
cord-006229-7yoilsho	4506	16	to	to	IN
cord-006229-7yoilsho	4506	17	multiple	multiple	JJ
cord-006229-7yoilsho	4506	18	etiologic	etiologic	JJ
cord-006229-7yoilsho	4506	19	factors	factor	NNS
cord-006229-7yoilsho	4506	20	involved	involve	VBN
cord-006229-7yoilsho	4506	21	in	in	IN
cord-006229-7yoilsho	4506	22	FGDs	fgd	NNS
cord-006229-7yoilsho	4506	23	,	,	,
cord-006229-7yoilsho	4506	24	especially	especially	RB
cord-006229-7yoilsho	4506	25	functional	functional	JJ
cord-006229-7yoilsho	4506	26	dyspepsia	dyspepsia	NN
cord-006229-7yoilsho	4506	27	and	and	CC
cord-006229-7yoilsho	4506	28	irritable	irritable	JJ
cord-006229-7yoilsho	4506	29	bowel	bowel	NN
cord-006229-7yoilsho	4506	30	syndrome	syndrome	NN
cord-006229-7yoilsho	4506	31	,	,	,
cord-006229-7yoilsho	4506	32	and	and	CC
cord-006229-7yoilsho	4506	33	to	to	TO
cord-006229-7yoilsho	4506	34	which	which	WDT
cord-006229-7yoilsho	4506	35	extent	extent	NN
cord-006229-7yoilsho	4506	36	the	the	DT
cord-006229-7yoilsho	4506	37	herbal	herbal	JJ
cord-006229-7yoilsho	4506	38	extract	extract	NN
cord-006229-7yoilsho	4506	39	components	component	NNS
cord-006229-7yoilsho	4506	40	of	of	IN
cord-006229-7yoilsho	4506	41	the	the	DT
cord-006229-7yoilsho	4506	42	combination	combination	NN
cord-006229-7yoilsho	4506	43	are	be	VBP
cord-006229-7yoilsho	4506	44	relevant	relevant	JJ
cord-006229-7yoilsho	4506	45	for	for	IN
cord-006229-7yoilsho	4506	46	the	the	DT
cord-006229-7yoilsho	4506	47	different	different	JJ
cord-006229-7yoilsho	4506	48	mechanisms	mechanism	NNS
cord-006229-7yoilsho	4506	49	of	of	IN
cord-006229-7yoilsho	4506	50	action	action	NN
cord-006229-7yoilsho	4506	51	and	and	CC
cord-006229-7yoilsho	4506	52	their	-PRON-	PRP$
cord-006229-7yoilsho	4506	53	translation	translation	NN
cord-006229-7yoilsho	4506	54	to	to	IN
cord-006229-7yoilsho	4506	55	clinical	clinical	JJ
cord-006229-7yoilsho	4506	56	efficacy	efficacy	NN
cord-006229-7yoilsho	4506	57	.	.	.
cord-006229-7yoilsho	4507	1	Conclusion	conclusion	NN
cord-006229-7yoilsho	4507	2	:	:	:
cord-006229-7yoilsho	4508	1	Multi	multi	JJ
cord-006229-7yoilsho	4508	2	step	step	NN
cord-006229-7yoilsho	4508	3	clustering	clustering	NN
cord-006229-7yoilsho	4508	4	allows	allow	VBZ
cord-006229-7yoilsho	4508	5	the	the	DT
cord-006229-7yoilsho	4508	6	transformation	transformation	NN
cord-006229-7yoilsho	4508	7	of	of	IN
cord-006229-7yoilsho	4508	8	complex	complex	JJ
cord-006229-7yoilsho	4508	9	data	data	NN
cord-006229-7yoilsho	4508	10	sets	set	NNS
cord-006229-7yoilsho	4508	11	.	.	.
cord-006229-7yoilsho	4509	1	It	-PRON-	PRP
cord-006229-7yoilsho	4509	2	makes	make	VBZ
cord-006229-7yoilsho	4509	3	the	the	DT
cord-006229-7yoilsho	4509	4	allocation	allocation	NN
cord-006229-7yoilsho	4509	5	of	of	IN
cord-006229-7yoilsho	4509	6	specific	specific	JJ
cord-006229-7yoilsho	4509	7	actions	action	NNS
cord-006229-7yoilsho	4509	8	to	to	IN
cord-006229-7yoilsho	4509	9	the	the	DT
cord-006229-7yoilsho	4509	10	different	different	JJ
cord-006229-7yoilsho	4509	11	components	component	NNS
cord-006229-7yoilsho	4509	12	of	of	IN
cord-006229-7yoilsho	4509	13	STW	STW	NNP
cord-006229-7yoilsho	4509	14	5	5	CD
cord-006229-7yoilsho	4509	15	manageable	manageable	JJ
cord-006229-7yoilsho	4509	16	,	,	,
cord-006229-7yoilsho	4509	17	so	so	RB
cord-006229-7yoilsho	4509	18	also	also	RB
cord-006229-7yoilsho	4509	19	giving	give	VBG
cord-006229-7yoilsho	4509	20	support	support	NN
cord-006229-7yoilsho	4509	21	to	to	IN
cord-006229-7yoilsho	4509	22	its	-PRON-	PRP$
cord-006229-7yoilsho	4509	23	clinical	clinical	JJ
cord-006229-7yoilsho	4509	24	use	use	NN
cord-006229-7yoilsho	4509	25	in	in	IN
cord-006229-7yoilsho	4509	26	patients	patient	NNS
cord-006229-7yoilsho	4509	27	with	with	IN
cord-006229-7yoilsho	4509	28	different	different	JJ
cord-006229-7yoilsho	4509	29	symptoms	symptom	NNS
cord-006229-7yoilsho	4509	30	.	.	.
cord-006229-7yoilsho	4510	1	Introduction	introduction	NN
cord-006229-7yoilsho	4510	2	:	:	:
cord-006229-7yoilsho	4511	1	STW	STW	NNP
cord-006229-7yoilsho	4511	2	5	5	CD
cord-006229-7yoilsho	4511	3	II	II	NNP
cord-006229-7yoilsho	4511	4	has	have	VBZ
cord-006229-7yoilsho	4511	5	been	be	VBN
cord-006229-7yoilsho	4511	6	recently	recently	RB
cord-006229-7yoilsho	4511	7	developed	develop	VBN
cord-006229-7yoilsho	4511	8	in	in	IN
cord-006229-7yoilsho	4511	9	an	an	DT
cord-006229-7yoilsho	4511	10	effort	effort	NN
cord-006229-7yoilsho	4511	11	to	to	TO
cord-006229-7yoilsho	4511	12	reduce	reduce	VB
cord-006229-7yoilsho	4511	13	the	the	DT
cord-006229-7yoilsho	4511	14	number	number	NN
cord-006229-7yoilsho	4511	15	of	of	IN
cord-006229-7yoilsho	4511	16	active	active	JJ
cord-006229-7yoilsho	4511	17	extracts	extract	NNS
cord-006229-7yoilsho	4511	18	in	in	IN
cord-006229-7yoilsho	4511	19	the	the	DT
cord-006229-7yoilsho	4511	20	mother	mother	NN
cord-006229-7yoilsho	4511	21	multi	multi	JJ
cord-006229-7yoilsho	4511	22	-	-	JJ
cord-006229-7yoilsho	4511	23	component	component	JJ
cord-006229-7yoilsho	4511	24	herbal	herbal	JJ
cord-006229-7yoilsho	4511	25	preparation	preparation	NN
cord-006229-7yoilsho	4511	26	,	,	,
cord-006229-7yoilsho	4511	27	STW	STW	NNP
cord-006229-7yoilsho	4511	28	5	5	CD
cord-006229-7yoilsho	4512	1	(	(	-LRB-
cord-006229-7yoilsho	4512	2	Iberogast	Iberogast	NNP
cord-006229-7yoilsho	4512	3	®	®	NNP
cord-006229-7yoilsho	4512	4	,	,	,
cord-006229-7yoilsho	4512	5	Steigerwald	Steigerwald	NNP
cord-006229-7yoilsho	4512	6	Arzneimittelwerk	Arzneimittelwerk	NNP
cord-006229-7yoilsho	4512	7	GmbH	GmbH	NNP
cord-006229-7yoilsho	4512	8	,	,	,
cord-006229-7yoilsho	4512	9	Darmstadt	Darmstadt	NNP
cord-006229-7yoilsho	4512	10	,	,	,
cord-006229-7yoilsho	4512	11	Germany	Germany	NNP
cord-006229-7yoilsho	4512	12	)	)	-RRB-
cord-006229-7yoilsho	4512	13	without	without	IN
cord-006229-7yoilsho	4512	14	affecting	affect	VBG
cord-006229-7yoilsho	4512	15	the	the	DT
cord-006229-7yoilsho	4512	16	overall	overall	JJ
cord-006229-7yoilsho	4512	17	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	4512	18	efficiency	efficiency	NN
cord-006229-7yoilsho	4512	19	.	.	.
cord-006229-7yoilsho	4513	1	STW	STW	NNP
cord-006229-7yoilsho	4513	2	5	5	CD
cord-006229-7yoilsho	4513	3	consists	consist	VBZ
cord-006229-7yoilsho	4513	4	of	of	IN
cord-006229-7yoilsho	4513	5	a	a	DT
cord-006229-7yoilsho	4513	6	mixture	mixture	NN
cord-006229-7yoilsho	4513	7	of	of	IN
cord-006229-7yoilsho	4513	8	9	9	CD
cord-006229-7yoilsho	4513	9	standardized	standardized	JJ
cord-006229-7yoilsho	4513	10	extracts	extract	NNS
cord-006229-7yoilsho	4513	11	:	:	:
cord-006229-7yoilsho	4513	12	bitter	bitter	JJ
cord-006229-7yoilsho	4513	13	candytuft	candytuft	NN
cord-006229-7yoilsho	4513	14	(	(	-LRB-
cord-006229-7yoilsho	4513	15	Iberis	Iberis	NNP
cord-006229-7yoilsho	4513	16	amara	amara	NNP
cord-006229-7yoilsho	4513	17	)	)	-RRB-
cord-006229-7yoilsho	4513	18	,	,	,
cord-006229-7yoilsho	4513	19	lemon	lemon	NN
cord-006229-7yoilsho	4513	20	balm	balm	NN
cord-006229-7yoilsho	4513	21	(	(	-LRB-
cord-006229-7yoilsho	4513	22	Melissa	Melissa	NNP
cord-006229-7yoilsho	4513	23	officinalis	officinalis	JJ
cord-006229-7yoilsho	4513	24	)	)	-RRB-
cord-006229-7yoilsho	4513	25	,	,	,
cord-006229-7yoilsho	4513	26	chamomile	chamomile	NN
cord-006229-7yoilsho	4513	27	(	(	-LRB-
cord-006229-7yoilsho	4513	28	Matricaria	Matricaria	NNP
cord-006229-7yoilsho	4513	29	recutita	recutita	NNP
cord-006229-7yoilsho	4513	30	)	)	-RRB-
cord-006229-7yoilsho	4513	31	,	,	,
cord-006229-7yoilsho	4513	32	caraway	caraway	NN
cord-006229-7yoilsho	4513	33	fruit	fruit	NN
cord-006229-7yoilsho	4513	34	(	(	-LRB-
cord-006229-7yoilsho	4513	35	Carum	Carum	NNP
cord-006229-7yoilsho	4513	36	carvi	carvi	NN
cord-006229-7yoilsho	4513	37	)	)	-RRB-
cord-006229-7yoilsho	4513	38	,	,	,
cord-006229-7yoilsho	4513	39	peppermint	peppermint	NN
cord-006229-7yoilsho	4513	40	leaf	leaf	NN
cord-006229-7yoilsho	4513	41	(	(	-LRB-
cord-006229-7yoilsho	4513	42	Mentha	Mentha	NNP
cord-006229-7yoilsho	4513	43	piperita	piperita	NNP
cord-006229-7yoilsho	4513	44	)	)	-RRB-
cord-006229-7yoilsho	4513	45	,	,	,
cord-006229-7yoilsho	4513	46	liquorice	liquorice	NN
cord-006229-7yoilsho	4513	47	root	root	NN
cord-006229-7yoilsho	4513	48	(	(	-LRB-
cord-006229-7yoilsho	4513	49	Glycyrrhiza	Glycyrrhiza	NNP
cord-006229-7yoilsho	4513	50	glabra	glabra	RB
cord-006229-7yoilsho	4513	51	)	)	-RRB-
cord-006229-7yoilsho	4513	52	,	,	,
cord-006229-7yoilsho	4513	53	Angelica	Angelica	NNP
cord-006229-7yoilsho	4513	54	root	root	NN
cord-006229-7yoilsho	4513	55	(	(	-LRB-
cord-006229-7yoilsho	4513	56	Angelica	Angelica	NNP
cord-006229-7yoilsho	4513	57	archangelica	archangelica	NNP
cord-006229-7yoilsho	4513	58	)	)	-RRB-
cord-006229-7yoilsho	4513	59	,	,	,
cord-006229-7yoilsho	4513	60	milk	milk	NN
cord-006229-7yoilsho	4513	61	thistle	thistle	NN
cord-006229-7yoilsho	4513	62	(	(	-LRB-
cord-006229-7yoilsho	4513	63	Silybum	Silybum	NNP
cord-006229-7yoilsho	4513	64	marianum	marianum	NNP
cord-006229-7yoilsho	4513	65	)	)	-RRB-
cord-006229-7yoilsho	4513	66	and	and	CC
cord-006229-7yoilsho	4513	67	celandine	celandine	NNP
cord-006229-7yoilsho	4513	68	herb	herb	NN
cord-006229-7yoilsho	4513	69	(	(	-LRB-
cord-006229-7yoilsho	4513	70	Chelidonium	Chelidonium	NNP
cord-006229-7yoilsho	4513	71	majus	majus	NNP
cord-006229-7yoilsho	4513	72	)	)	-RRB-
cord-006229-7yoilsho	4513	73	,	,	,
cord-006229-7yoilsho	4513	74	whereas	whereas	IN
cord-006229-7yoilsho	4513	75	STW	STW	NNP
cord-006229-7yoilsho	4513	76	5	5	CD
cord-006229-7yoilsho	4513	77	II	II	NNP
cord-006229-7yoilsho	4513	78	lacks	lack	VBZ
cord-006229-7yoilsho	4513	79	the	the	DT
cord-006229-7yoilsho	4513	80	last	last	JJ
cord-006229-7yoilsho	4513	81	3	3	CD
cord-006229-7yoilsho	4513	82	components	component	NNS
cord-006229-7yoilsho	4513	83	.	.	.
cord-006229-7yoilsho	4514	1	STW	STW	NNP
cord-006229-7yoilsho	4514	2	5	5	CD
cord-006229-7yoilsho	4514	3	was	be	VBD
cord-006229-7yoilsho	4514	4	shown	show	VBN
cord-006229-7yoilsho	4514	5	to	to	TO
cord-006229-7yoilsho	4514	6	be	be	VB
cord-006229-7yoilsho	4514	7	effective	effective	JJ
cord-006229-7yoilsho	4514	8	clinically	clinically	RB
cord-006229-7yoilsho	4514	9	to	to	TO
cord-006229-7yoilsho	4514	10	treat	treat	VB
cord-006229-7yoilsho	4514	11	functional	functional	JJ
cord-006229-7yoilsho	4514	12	dyspepsia	dyspepsia	NN
cord-006229-7yoilsho	4514	13	(	(	-LRB-
cord-006229-7yoilsho	4514	14	1	1	CD
cord-006229-7yoilsho	4514	15	)	)	-RRB-
cord-006229-7yoilsho	4514	16	and	and	CC
cord-006229-7yoilsho	4514	17	irritable	irritable	JJ
cord-006229-7yoilsho	4514	18	bowel	bowel	NN
cord-006229-7yoilsho	4514	19	syndrome	syndrome	NN
cord-006229-7yoilsho	4514	20	(	(	-LRB-
cord-006229-7yoilsho	4514	21	2	2	CD
cord-006229-7yoilsho	4514	22	)	)	-RRB-
cord-006229-7yoilsho	4514	23	and	and	CC
cord-006229-7yoilsho	4514	24	was	be	VBD
cord-006229-7yoilsho	4514	25	shown	show	VBN
cord-006229-7yoilsho	4514	26	experimentally	experimentally	RB
cord-006229-7yoilsho	4514	27	to	to	TO
cord-006229-7yoilsho	4514	28	be	be	VB
cord-006229-7yoilsho	4514	29	effective	effective	JJ
cord-006229-7yoilsho	4514	30	to	to	TO
cord-006229-7yoilsho	4514	31	guard	guard	VB
cord-006229-7yoilsho	4514	32	against	against	IN
cord-006229-7yoilsho	4514	33	the	the	DT
cord-006229-7yoilsho	4514	34	development	development	NN
cord-006229-7yoilsho	4514	35	of	of	IN
cord-006229-7yoilsho	4514	36	radiation	radiation	NN
cord-006229-7yoilsho	4514	37	induced	induce	VBN
cord-006229-7yoilsho	4514	38	intestinal	intestinal	JJ
cord-006229-7yoilsho	4514	39	mucositis	mucositis	NNP
cord-006229-7yoilsho	4514	40	(	(	-LRB-
cord-006229-7yoilsho	4514	41	3	3	CD
cord-006229-7yoilsho	4514	42	)	)	-RRB-
cord-006229-7yoilsho	4514	43	and	and	CC
cord-006229-7yoilsho	4514	44	in	in	IN
cord-006229-7yoilsho	4514	45	the	the	DT
cord-006229-7yoilsho	4514	46	management	management	NN
cord-006229-7yoilsho	4514	47	of	of	IN
cord-006229-7yoilsho	4514	48	ulcerative	ulcerative	JJ
cord-006229-7yoilsho	4514	49	colitis	colitis	NNP
cord-006229-7yoilsho	4514	50	(	(	-LRB-
cord-006229-7yoilsho	4514	51	4	4	CD
cord-006229-7yoilsho	4514	52	)	)	-RRB-
cord-006229-7yoilsho	4514	53	.	.	.
cord-006229-7yoilsho	4515	1	The	the	DT
cord-006229-7yoilsho	4515	2	present	present	JJ
cord-006229-7yoilsho	4515	3	study	study	NN
cord-006229-7yoilsho	4515	4	was	be	VBD
cord-006229-7yoilsho	4515	5	initiated	initiate	VBN
cord-006229-7yoilsho	4515	6	to	to	TO
cord-006229-7yoilsho	4515	7	show	show	VB
cord-006229-7yoilsho	4515	8	whether	whether	IN
cord-006229-7yoilsho	4515	9	STW	STW	NNP
cord-006229-7yoilsho	4515	10	5	5	CD
cord-006229-7yoilsho	4515	11	II	II	NNP
cord-006229-7yoilsho	4515	12	with	with	IN
cord-006229-7yoilsho	4515	13	the	the	DT
cord-006229-7yoilsho	4515	14	reduced	reduce	VBN
cord-006229-7yoilsho	4515	15	component	component	NN
cord-006229-7yoilsho	4515	16	extracts	extract	NNS
cord-006229-7yoilsho	4515	17	would	would	MD
cord-006229-7yoilsho	4515	18	also	also	RB
cord-006229-7yoilsho	4515	19	be	be	VB
cord-006229-7yoilsho	4515	20	as	as	RB
cord-006229-7yoilsho	4515	21	effective	effective	JJ
cord-006229-7yoilsho	4515	22	in	in	IN
cord-006229-7yoilsho	4515	23	the	the	DT
cord-006229-7yoilsho	4515	24	latter	latter	JJ
cord-006229-7yoilsho	4515	25	condition	condition	NN
cord-006229-7yoilsho	4515	26	.	.	.
cord-006229-7yoilsho	4516	1	This	this	DT
cord-006229-7yoilsho	4516	2	was	be	VBD
cord-006229-7yoilsho	4516	3	induced	induce	VBN
cord-006229-7yoilsho	4516	4	in	in	IN
cord-006229-7yoilsho	4516	5	Wistar	Wistar	NNP
cord-006229-7yoilsho	4516	6	rats	rat	NNS
cord-006229-7yoilsho	4516	7	by	by	IN
cord-006229-7yoilsho	4516	8	feeding	feed	VBG
cord-006229-7yoilsho	4516	9	them	-PRON-	PRP
cord-006229-7yoilsho	4516	10	with	with	IN
cord-006229-7yoilsho	4516	11	5	5	CD
cord-006229-7yoilsho	4516	12	%	%	NN
cord-006229-7yoilsho	4516	13	Dextran	dextran	NN
cord-006229-7yoilsho	4516	14	sodium	sodium	NN
cord-006229-7yoilsho	4516	15	sulfate	sulfate	NN
cord-006229-7yoilsho	4516	16	in	in	IN
cord-006229-7yoilsho	4516	17	drinking	drinking	NN
cord-006229-7yoilsho	4516	18	water	water	NN
cord-006229-7yoilsho	4516	19	for	for	IN
cord-006229-7yoilsho	4516	20	1	1	CD
cord-006229-7yoilsho	4516	21	week	week	NN
cord-006229-7yoilsho	4516	22	when	when	WRB
cord-006229-7yoilsho	4516	23	lesions	lesion	NNS
cord-006229-7yoilsho	4516	24	were	be	VBD
cord-006229-7yoilsho	4516	25	observed	observe	VBN
cord-006229-7yoilsho	4516	26	in	in	IN
cord-006229-7yoilsho	4516	27	the	the	DT
cord-006229-7yoilsho	4516	28	colon	colon	NN
cord-006229-7yoilsho	4516	29	evidenced	evidence	VBN
cord-006229-7yoilsho	4516	30	by	by	IN
cord-006229-7yoilsho	4516	31	histological	histological	JJ
cord-006229-7yoilsho	4516	32	examination	examination	NN
cord-006229-7yoilsho	4516	33	as	as	RB
cord-006229-7yoilsho	4516	34	well	well	RB
cord-006229-7yoilsho	4516	35	as	as	IN
cord-006229-7yoilsho	4516	36	colon	colon	NN
cord-006229-7yoilsho	4516	37	shortening	shortening	NN
cord-006229-7yoilsho	4516	38	and	and	CC
cord-006229-7yoilsho	4516	39	reduction	reduction	NN
cord-006229-7yoilsho	4516	40	of	of	IN
cord-006229-7yoilsho	4516	41	colon	colon	NN
cord-006229-7yoilsho	4516	42	mass	mass	NN
cord-006229-7yoilsho	4516	43	index	index	NN
cord-006229-7yoilsho	4516	44	.	.	.
cord-006229-7yoilsho	4517	1	This	this	DT
cord-006229-7yoilsho	4517	2	was	be	VBD
cord-006229-7yoilsho	4517	3	associated	associate	VBN
cord-006229-7yoilsho	4517	4	with	with	IN
cord-006229-7yoilsho	4517	5	a	a	DT
cord-006229-7yoilsho	4517	6	rise	rise	NN
cord-006229-7yoilsho	4517	7	in	in	IN
cord-006229-7yoilsho	4517	8	myeloperoxidase	myeloperoxidase	NN
cord-006229-7yoilsho	4517	9	and	and	CC
cord-006229-7yoilsho	4517	10	a	a	DT
cord-006229-7yoilsho	4517	11	fall	fall	NN
cord-006229-7yoilsho	4517	12	in	in	IN
cord-006229-7yoilsho	4517	13	reduced	reduce	VBN
cord-006229-7yoilsho	4517	14	glutathione	glutathione	NN
cord-006229-7yoilsho	4517	15	,	,	,
cord-006229-7yoilsho	4517	16	glutathione	glutathione	NN
cord-006229-7yoilsho	4517	17	peroxidase	peroxidase	NN
cord-006229-7yoilsho	4517	18	,	,	,
cord-006229-7yoilsho	4517	19	and	and	CC
cord-006229-7yoilsho	4517	20	superoxide	superoxide	NN
cord-006229-7yoilsho	4517	21	dismutase	dismutase	NN
cord-006229-7yoilsho	4517	22	in	in	IN
cord-006229-7yoilsho	4517	23	colon	colon	NN
cord-006229-7yoilsho	4517	24	homogenates	homogenate	NNS
cord-006229-7yoilsho	4517	25	as	as	RB
cord-006229-7yoilsho	4517	26	well	well	RB
cord-006229-7yoilsho	4517	27	as	as	IN
cord-006229-7yoilsho	4517	28	a	a	DT
cord-006229-7yoilsho	4517	29	rise	rise	NN
cord-006229-7yoilsho	4517	30	in	in	IN
cord-006229-7yoilsho	4517	31	TNFα	TNFα	NNS
cord-006229-7yoilsho	4517	32	in	in	IN
cord-006229-7yoilsho	4517	33	serum	serum	NN
cord-006229-7yoilsho	4517	34	.	.	.
cord-006229-7yoilsho	4518	1	Oral	oral	JJ
cord-006229-7yoilsho	4518	2	administration	administration	NN
cord-006229-7yoilsho	4518	3	of	of	IN
cord-006229-7yoilsho	4518	4	STW	STW	NNP
cord-006229-7yoilsho	4518	5	5	5	CD
cord-006229-7yoilsho	4518	6	in	in	IN
cord-006229-7yoilsho	4518	7	doses	dose	NNS
cord-006229-7yoilsho	4518	8	of	of	IN
cord-006229-7yoilsho	4518	9	2	2	CD
cord-006229-7yoilsho	4518	10	and	and	CC
cord-006229-7yoilsho	4518	11	5	5	CD
cord-006229-7yoilsho	4518	12	ml	ml	NNS
cord-006229-7yoilsho	4518	13	/	/	SYM
cord-006229-7yoilsho	4518	14	kg	kg	NNP
cord-006229-7yoilsho	4518	15	or	or	CC
cord-006229-7yoilsho	4518	16	STW	STW	NNP
cord-006229-7yoilsho	4518	17	5	5	CD
cord-006229-7yoilsho	4518	18	II	II	NNP
cord-006229-7yoilsho	4518	19	in	in	IN
cord-006229-7yoilsho	4518	20	a	a	DT
cord-006229-7yoilsho	4518	21	dose	dose	NN
cord-006229-7yoilsho	4518	22	of	of	IN
cord-006229-7yoilsho	4518	23	2	2	CD
cord-006229-7yoilsho	4518	24	ml	ml	NN
cord-006229-7yoilsho	4518	25	/	/	SYM
cord-006229-7yoilsho	4518	26	kg	kg	NN
cord-006229-7yoilsho	4518	27	for	for	IN
cord-006229-7yoilsho	4518	28	1	1	CD
cord-006229-7yoilsho	4518	29	week	week	NN
cord-006229-7yoilsho	4518	30	before	before	RB
cord-006229-7yoilsho	4518	31	and	and	CC
cord-006229-7yoilsho	4518	32	continued	continue	VBD
cord-006229-7yoilsho	4518	33	during	during	IN
cord-006229-7yoilsho	4518	34	DSS	DSS	NNP
cord-006229-7yoilsho	4518	35	feeding	feeding	NN
cord-006229-7yoilsho	4518	36	tended	tend	VBD
cord-006229-7yoilsho	4518	37	to	to	TO
cord-006229-7yoilsho	4518	38	normalize	normalize	VB
cord-006229-7yoilsho	4518	39	all	all	PDT
cord-006229-7yoilsho	4518	40	the	the	DT
cord-006229-7yoilsho	4518	41	changes	change	NNS
cord-006229-7yoilsho	4518	42	in	in	IN
cord-006229-7yoilsho	4518	43	a	a	DT
cord-006229-7yoilsho	4518	44	fashion	fashion	NN
cord-006229-7yoilsho	4518	45	comparable	comparable	JJ
cord-006229-7yoilsho	4518	46	to	to	IN
cord-006229-7yoilsho	4518	47	sulfasalazine	sulfasalazine	NNP
cord-006229-7yoilsho	4518	48	,	,	,
cord-006229-7yoilsho	4518	49	used	use	VBN
cord-006229-7yoilsho	4518	50	as	as	IN
cord-006229-7yoilsho	4518	51	a	a	DT
cord-006229-7yoilsho	4518	52	reference	reference	NN
cord-006229-7yoilsho	4518	53	drug	drug	NN
cord-006229-7yoilsho	4518	54	in	in	IN
cord-006229-7yoilsho	4518	55	a	a	DT
cord-006229-7yoilsho	4518	56	dose	dose	NN
cord-006229-7yoilsho	4518	57	of	of	IN
cord-006229-7yoilsho	4518	58	300	300	CD
cord-006229-7yoilsho	4518	59	mg	mg	NN
cord-006229-7yoilsho	4518	60	/	/	SYM
cord-006229-7yoilsho	4518	61	kg	kg	NNP
cord-006229-7yoilsho	4518	62	.	.	.
cord-006229-7yoilsho	4519	1	Conclusions	conclusion	NNS
cord-006229-7yoilsho	4519	2	:	:	:
cord-006229-7yoilsho	4520	1	The	the	DT
cord-006229-7yoilsho	4520	2	modified	modify	VBN
cord-006229-7yoilsho	4520	3	preparation	preparation	NN
cord-006229-7yoilsho	4520	4	,	,	,
cord-006229-7yoilsho	4520	5	STW	STW	NNP
cord-006229-7yoilsho	4520	6	5	5	CD
cord-006229-7yoilsho	4520	7	II	II	NNP
cord-006229-7yoilsho	4520	8	thus	thus	RB
cord-006229-7yoilsho	4520	9	proved	prove	VBD
cord-006229-7yoilsho	4520	10	to	to	TO
cord-006229-7yoilsho	4520	11	be	be	VB
cord-006229-7yoilsho	4520	12	as	as	RB
cord-006229-7yoilsho	4520	13	effective	effective	JJ
cord-006229-7yoilsho	4520	14	as	as	IN
cord-006229-7yoilsho	4520	15	STW	STW	NNP
cord-006229-7yoilsho	4520	16	5	5	CD
cord-006229-7yoilsho	4520	17	,	,	,
cord-006229-7yoilsho	4520	18	thereby	thereby	RB
cord-006229-7yoilsho	4520	19	reflecting	reflect	VBG
cord-006229-7yoilsho	4520	20	its	-PRON-	PRP$
cord-006229-7yoilsho	4520	21	potential	potential	JJ
cord-006229-7yoilsho	4520	22	usefulness	usefulness	NN
cord-006229-7yoilsho	4520	23	in	in	IN
cord-006229-7yoilsho	4520	24	ulcerative	ulcerative	JJ
cord-006229-7yoilsho	4520	25	colitis	colitis	NN
cord-006229-7yoilsho	4520	26	possibly	possibly	RB
cord-006229-7yoilsho	4520	27	by	by	IN
cord-006229-7yoilsho	4520	28	virtue	virtue	NN
cord-006229-7yoilsho	4520	29	of	of	IN
cord-006229-7yoilsho	4520	30	its	-PRON-	PRP$
cord-006229-7yoilsho	4520	31	anti	anti	JJ
cord-006229-7yoilsho	4520	32	-	-	JJ
cord-006229-7yoilsho	4520	33	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	4520	34	and	and	CC
cord-006229-7yoilsho	4520	35	anti	anti	JJ
cord-006229-7yoilsho	4520	36	-	-	JJ
cord-006229-7yoilsho	4520	37	oxidant	oxidant	JJ
cord-006229-7yoilsho	4520	38	properties	property	NNS
cord-006229-7yoilsho	4520	39	.	.	.
cord-006229-7yoilsho	4521	1	(	(	-LRB-
cord-006229-7yoilsho	4521	2	1	1	LS
cord-006229-7yoilsho	4521	3	)	)	-RRB-
cord-006229-7yoilsho	4521	4	Schmulson	Schmulson	NNP
cord-006229-7yoilsho	4521	5	MJ	MJ	NNP
cord-006229-7yoilsho	4521	6	(	(	-LRB-
cord-006229-7yoilsho	4521	7	2008	2008	CD
cord-006229-7yoilsho	4521	8	)	)	-RRB-
cord-006229-7yoilsho	4522	1	The	the	DT
cord-006229-7yoilsho	4522	2	emetic	emetic	JJ
cord-006229-7yoilsho	4522	3	pathways	pathway	NNS
cord-006229-7yoilsho	4522	4	include	include	VBP
cord-006229-7yoilsho	4522	5	the	the	DT
cord-006229-7yoilsho	4522	6	action	action	NN
cord-006229-7yoilsho	4522	7	of	of	IN
cord-006229-7yoilsho	4522	8	neurotransmitters	neurotransmitter	NNS
cord-006229-7yoilsho	4522	9	dopamine	dopamine	NN
cord-006229-7yoilsho	4522	10	,	,	,
cord-006229-7yoilsho	4522	11	serotonin	serotonin	NN
cord-006229-7yoilsho	4522	12	and	and	CC
cord-006229-7yoilsho	4522	13	substance	substance	NN
cord-006229-7yoilsho	4522	14	p	p	NN
cord-006229-7yoilsho	4522	15	in	in	IN
cord-006229-7yoilsho	4522	16	the	the	DT
cord-006229-7yoilsho	4522	17	emetic	emetic	JJ
cord-006229-7yoilsho	4522	18	centers	center	NNS
cord-006229-7yoilsho	4522	19	localized	localize	VBN
cord-006229-7yoilsho	4522	20	in	in	IN
cord-006229-7yoilsho	4522	21	the	the	DT
cord-006229-7yoilsho	4522	22	brainstem	brainstem	NN
cord-006229-7yoilsho	4522	23	,	,	,
cord-006229-7yoilsho	4522	24	area	area	NN
cord-006229-7yoilsho	4522	25	postrema	postrema	JJ
cord-006229-7yoilsho	4522	26	and	and	CC
cord-006229-7yoilsho	4522	27	vagal	vagal	JJ
cord-006229-7yoilsho	4522	28	nerve	nerve	NN
cord-006229-7yoilsho	4522	29	afferents	afferent	NNS
cord-006229-7yoilsho	4522	30	.	.	.
cord-006229-7yoilsho	4523	1	Previous	previous	JJ
cord-006229-7yoilsho	4523	2	in	in	IN
cord-006229-7yoilsho	4523	3	vivo	vivo	NNP
cord-006229-7yoilsho	4523	4	studies	study	NNS
cord-006229-7yoilsho	4523	5	in	in	IN
cord-006229-7yoilsho	4523	6	beagle	beagle	NNP
cord-006229-7yoilsho	4523	7	dogs	dog	NNS
cord-006229-7yoilsho	4523	8	revealed	reveal	VBD
cord-006229-7yoilsho	4523	9	that	that	IN
cord-006229-7yoilsho	4523	10	the	the	DT
cord-006229-7yoilsho	4523	11	plant	plant	NN
cord-006229-7yoilsho	4523	12	alkaloid	alkaloid	NN
cord-006229-7yoilsho	4523	13	lycorine	lycorine	NN
cord-006229-7yoilsho	4523	14	potentially	potentially	RB
cord-006229-7yoilsho	4523	15	induce	induce	VBP
cord-006229-7yoilsho	4523	16	nausea	nausea	NN
cord-006229-7yoilsho	4523	17	and	and	CC
cord-006229-7yoilsho	4523	18	emesis	emesis	NN
cord-006229-7yoilsho	4523	19	.	.	.
cord-006229-7yoilsho	4524	1	Though	though	IN
cord-006229-7yoilsho	4524	2	antagonists	antagonist	NNS
cord-006229-7yoilsho	4524	3	of	of	IN
cord-006229-7yoilsho	4524	4	the	the	DT
cord-006229-7yoilsho	4524	5	tachykinin	tachykinin	NNP
cord-006229-7yoilsho	4524	6	receptor	receptor	NN
cord-006229-7yoilsho	4524	7	1	1	CD
cord-006229-7yoilsho	4524	8	(	(	-LRB-
cord-006229-7yoilsho	4524	9	maropitant	maropitant	NN
cord-006229-7yoilsho	4524	10	)	)	-RRB-
cord-006229-7yoilsho	4524	11	and	and	CC
cord-006229-7yoilsho	4524	12	serotonin	serotonin	NN
cord-006229-7yoilsho	4524	13	receptor	receptor	NN
cord-006229-7yoilsho	4524	14	3	3	CD
cord-006229-7yoilsho	4524	15	(	(	-LRB-
cord-006229-7yoilsho	4524	16	ondansetron	ondansetron	NN
cord-006229-7yoilsho	4524	17	)	)	-RRB-
cord-006229-7yoilsho	4524	18	prevented	prevent	VBD
cord-006229-7yoilsho	4524	19	lycorinemediated	lycorinemediate	VBN
cord-006229-7yoilsho	4524	20	emesis	emesis	NN
cord-006229-7yoilsho	4524	21	,	,	,
cord-006229-7yoilsho	4524	22	the	the	DT
cord-006229-7yoilsho	4524	23	molecular	molecular	JJ
cord-006229-7yoilsho	4524	24	mechanism	mechanism	NN
cord-006229-7yoilsho	4524	25	of	of	IN
cord-006229-7yoilsho	4524	26	nausea	nausea	NN
cord-006229-7yoilsho	4524	27	and	and	CC
cord-006229-7yoilsho	4524	28	vomiting	vomiting	NN
cord-006229-7yoilsho	4524	29	remain	remain	VBP
cord-006229-7yoilsho	4524	30	still	still	RB
cord-006229-7yoilsho	4524	31	unknown	unknown	JJ
cord-006229-7yoilsho	4524	32	.	.	.
cord-006229-7yoilsho	4525	1	To	to	TO
cord-006229-7yoilsho	4525	2	study	study	VB
cord-006229-7yoilsho	4525	3	the	the	DT
cord-006229-7yoilsho	4525	4	mechanism	mechanism	NN
cord-006229-7yoilsho	4525	5	of	of	IN
cord-006229-7yoilsho	4525	6	action	action	NN
cord-006229-7yoilsho	4525	7	of	of	IN
cord-006229-7yoilsho	4525	8	the	the	DT
cord-006229-7yoilsho	4525	9	emetic	emetic	JJ
cord-006229-7yoilsho	4525	10	agents	agent	NNS
cord-006229-7yoilsho	4525	11	,	,	,
cord-006229-7yoilsho	4525	12	we	-PRON-	PRP
cord-006229-7yoilsho	4525	13	analyzed	analyze	VBD
cord-006229-7yoilsho	4525	14	the	the	DT
cord-006229-7yoilsho	4525	15	effect	effect	NN
cord-006229-7yoilsho	4525	16	of	of	IN
cord-006229-7yoilsho	4525	17	lycorine	lycorine	NN
cord-006229-7yoilsho	4525	18	(	(	-LRB-
cord-006229-7yoilsho	4525	19	direct	direct	JJ
cord-006229-7yoilsho	4525	20	activation	activation	NN
cord-006229-7yoilsho	4525	21	of	of	IN
cord-006229-7yoilsho	4525	22	NK1	NK1	NNP
cord-006229-7yoilsho	4525	23	)	)	-RRB-
cord-006229-7yoilsho	4525	24	and	and	CC
cord-006229-7yoilsho	4525	25	channel	channel	NN
cord-006229-7yoilsho	4525	26	opening	opening	NN
cord-006229-7yoilsho	4525	27	(	(	-LRB-
cord-006229-7yoilsho	4525	28	activation	activation	NN
cord-006229-7yoilsho	4525	29	of	of	IN
cord-006229-7yoilsho	4525	30	5HT3	5ht3	CD
cord-006229-7yoilsho	4525	31	)	)	-RRB-
cord-006229-7yoilsho	4525	32	on	on	IN
cord-006229-7yoilsho	4525	33	the	the	DT
cord-006229-7yoilsho	4525	34	intracellular	intracellular	JJ
cord-006229-7yoilsho	4525	35	calcium	calcium	NN
cord-006229-7yoilsho	4525	36	homeostasis	homeostasis	NN
cord-006229-7yoilsho	4525	37	(	(	-LRB-
cord-006229-7yoilsho	4525	38	using	use	VBG
cord-006229-7yoilsho	4525	39	Fluorometric	Fluorometric	NNP
cord-006229-7yoilsho	4525	40	Ca	Ca	NNP
cord-006229-7yoilsho	4525	41	2	2	CD
cord-006229-7yoilsho	4525	42	+	+	CC
cord-006229-7yoilsho	4525	43	analysis	analysis	NN
cord-006229-7yoilsho	4525	44	)	)	-RRB-
cord-006229-7yoilsho	4525	45	and	and	CC
cord-006229-7yoilsho	4525	46	cell	cell	NN
cord-006229-7yoilsho	4525	47	proliferation	proliferation	NN
cord-006229-7yoilsho	4525	48	rates	rate	NNS
cord-006229-7yoilsho	4525	49	in	in	IN
cord-006229-7yoilsho	4525	50	endogenously	endogenously	RB
cord-006229-7yoilsho	4525	51	NK1	NK1	NNP
cord-006229-7yoilsho	4525	52	and	and	CC
cord-006229-7yoilsho	4525	53	5HT3	5ht3	CD
cord-006229-7yoilsho	4525	54	Receptor	receptor	NN
cord-006229-7yoilsho	4525	55	expressing	express	VBG
cord-006229-7yoilsho	4525	56	cell	cell	NN
cord-006229-7yoilsho	4525	57	lines	line	NNS
cord-006229-7yoilsho	4525	58	as	as	RB
cord-006229-7yoilsho	4525	59	well	well	RB
cord-006229-7yoilsho	4525	60	as	as	IN
cord-006229-7yoilsho	4525	61	in	in	IN
cord-006229-7yoilsho	4525	62	CHO	CHO	NNP
cord-006229-7yoilsho	4525	63	and	and	CC
cord-006229-7yoilsho	4525	64	HEK	HEK	NNP
cord-006229-7yoilsho	4525	65	cells	cell	NNS
cord-006229-7yoilsho	4525	66	stably	stably	RB
cord-006229-7yoilsho	4525	67	expressing	express	VBG
cord-006229-7yoilsho	4525	68	the	the	DT
cord-006229-7yoilsho	4525	69	receptors	receptor	NNS
cord-006229-7yoilsho	4525	70	.	.	.
cord-006229-7yoilsho	4526	1	Neither	neither	CC
cord-006229-7yoilsho	4526	2	endogenously	endogenously	RB
cord-006229-7yoilsho	4526	3	receptor	receptor	NN
cord-006229-7yoilsho	4526	4	expressing	express	VBG
cord-006229-7yoilsho	4526	5	NK1	NK1	NNP
cord-006229-7yoilsho	4526	6	or	or	CC
cord-006229-7yoilsho	4526	7	5HT3	5ht3	CD
cord-006229-7yoilsho	4526	8	cells	cell	NNS
cord-006229-7yoilsho	4526	9	nor	nor	CC
cord-006229-7yoilsho	4526	10	receptor	receptor	NN
cord-006229-7yoilsho	4526	11	overexpressing	overexpresse	VBG
cord-006229-7yoilsho	4526	12	cells	cell	NNS
cord-006229-7yoilsho	4526	13	showed	show	VBD
cord-006229-7yoilsho	4526	14	calciumflux	calciumflux	NN
cord-006229-7yoilsho	4526	15	or	or	CC
cord-006229-7yoilsho	4526	16	calcium	calcium	NN
cord-006229-7yoilsho	4526	17	mobilization	mobilization	NN
cord-006229-7yoilsho	4526	18	after	after	IN
cord-006229-7yoilsho	4526	19	stimulation	stimulation	NN
cord-006229-7yoilsho	4526	20	with	with	IN
cord-006229-7yoilsho	4526	21	lycorine	lycorine	NN
cord-006229-7yoilsho	4526	22	.	.	.
cord-006229-7yoilsho	4527	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	4527	2	,	,	,
cord-006229-7yoilsho	4527	3	we	-PRON-	PRP
cord-006229-7yoilsho	4527	4	are	be	VBP
cord-006229-7yoilsho	4527	5	measuring	measure	VBG
cord-006229-7yoilsho	4527	6	the	the	DT
cord-006229-7yoilsho	4527	7	receptor	receptor	NN
cord-006229-7yoilsho	4527	8	number	number	NN
cord-006229-7yoilsho	4527	9	and	and	CC
cord-006229-7yoilsho	4527	10	subtypes	subtype	NNS
cord-006229-7yoilsho	4527	11	using	use	VBG
cord-006229-7yoilsho	4527	12	radioligand	radioligand	JJ
cord-006229-7yoilsho	4527	13	binding	binding	JJ
cord-006229-7yoilsho	4527	14	studies	study	NNS
cord-006229-7yoilsho	4527	15	.	.	.
cord-006229-7yoilsho	4528	1	It	-PRON-	PRP
cord-006229-7yoilsho	4528	2	is	be	VBZ
cord-006229-7yoilsho	4528	3	planned	plan	VBN
cord-006229-7yoilsho	4528	4	,	,	,
cord-006229-7yoilsho	4528	5	moreover	moreover	RB
cord-006229-7yoilsho	4528	6	,	,	,
cord-006229-7yoilsho	4528	7	to	to	TO
cord-006229-7yoilsho	4528	8	obtain	obtain	VB
cord-006229-7yoilsho	4528	9	fluorescent	fluorescent	NN
cord-006229-7yoilsho	4528	10	labeled	label	VBN
cord-006229-7yoilsho	4528	11	constructs	construct	NNS
cord-006229-7yoilsho	4528	12	of	of	IN
cord-006229-7yoilsho	4528	13	the	the	DT
cord-006229-7yoilsho	4528	14	NK1	NK1	NNP
cord-006229-7yoilsho	4528	15	receptor	receptor	NN
cord-006229-7yoilsho	4528	16	to	to	TO
cord-006229-7yoilsho	4528	17	gain	gain	VB
cord-006229-7yoilsho	4528	18	insights	insight	NNS
cord-006229-7yoilsho	4528	19	into	into	IN
cord-006229-7yoilsho	4528	20	the	the	DT
cord-006229-7yoilsho	4528	21	involvement	involvement	NN
cord-006229-7yoilsho	4528	22	of	of	IN
cord-006229-7yoilsho	4528	23	receptor	receptor	NN
cord-006229-7yoilsho	4528	24	internalization	internalization	NN
cord-006229-7yoilsho	4528	25	which	which	WDT
cord-006229-7yoilsho	4528	26	might	may	MD
cord-006229-7yoilsho	4528	27	mediate	mediate	VB
cord-006229-7yoilsho	4528	28	emesis	emesis	NN
cord-006229-7yoilsho	4528	29	.	.	.
cord-006229-7yoilsho	4529	1	By	by	IN
cord-006229-7yoilsho	4529	2	characterizing	characterize	VBG
cord-006229-7yoilsho	4529	3	these	these	DT
cord-006229-7yoilsho	4529	4	molecular	molecular	JJ
cord-006229-7yoilsho	4529	5	principles	principle	NNS
cord-006229-7yoilsho	4529	6	of	of	IN
cord-006229-7yoilsho	4529	7	the	the	DT
cord-006229-7yoilsho	4529	8	NK1	NK1	NNP
cord-006229-7yoilsho	4529	9	and	and	CC
cord-006229-7yoilsho	4529	10	5HT3	5ht3	CD
cord-006229-7yoilsho	4529	11	receptors	receptor	NNS
cord-006229-7yoilsho	4529	12	,	,	,
cord-006229-7yoilsho	4529	13	we	-PRON-	PRP
cord-006229-7yoilsho	4529	14	are	be	VBP
cord-006229-7yoilsho	4529	15	attempting	attempt	VBG
cord-006229-7yoilsho	4529	16	to	to	TO
cord-006229-7yoilsho	4529	17	obtain	obtain	VB
cord-006229-7yoilsho	4529	18	more	more	JJR
cord-006229-7yoilsho	4529	19	information	information	NN
cord-006229-7yoilsho	4529	20	in	in	IN
cord-006229-7yoilsho	4529	21	predicting	predict	VBG
cord-006229-7yoilsho	4529	22	drug	drug	NN
cord-006229-7yoilsho	4529	23	-	-	HYPH
cord-006229-7yoilsho	4529	24	induced	induce	VBN
cord-006229-7yoilsho	4529	25	side	side	NN
cord-006229-7yoilsho	4529	26	effects	effect	NNS
cord-006229-7yoilsho	4529	27	such	such	JJ
cord-006229-7yoilsho	4529	28	as	as	IN
cord-006229-7yoilsho	4529	29	nausea	nausea	NN
cord-006229-7yoilsho	4529	30	and	and	CC
cord-006229-7yoilsho	4529	31	emesis	emesis	NN
cord-006229-7yoilsho	4529	32	.	.	.
cord-006229-7yoilsho	4530	1	The	the	DT
cord-006229-7yoilsho	4530	2	intestinal	intestinal	JJ
cord-006229-7yoilsho	4530	3	epithelium	epithelium	NN
cord-006229-7yoilsho	4530	4	is	be	VBZ
cord-006229-7yoilsho	4530	5	completely	completely	RB
cord-006229-7yoilsho	4530	6	renewed	renew	VBN
cord-006229-7yoilsho	4530	7	every	every	DT
cord-006229-7yoilsho	4530	8	4	4	CD
cord-006229-7yoilsho	4530	9	-	-	SYM
cord-006229-7yoilsho	4530	10	5	5	CD
cord-006229-7yoilsho	4530	11	days	day	NNS
cord-006229-7yoilsho	4530	12	.	.	.
cord-006229-7yoilsho	4531	1	This	this	DT
cord-006229-7yoilsho	4531	2	process	process	NN
cord-006229-7yoilsho	4531	3	is	be	VBZ
cord-006229-7yoilsho	4531	4	driven	drive	VBN
cord-006229-7yoilsho	4531	5	by	by	IN
cord-006229-7yoilsho	4531	6	stem	stem	NN
cord-006229-7yoilsho	4531	7	cells	cell	NNS
cord-006229-7yoilsho	4531	8	,	,	,
cord-006229-7yoilsho	4531	9	which	which	WDT
cord-006229-7yoilsho	4531	10	reside	reside	VBP
cord-006229-7yoilsho	4531	11	within	within	IN
cord-006229-7yoilsho	4531	12	specialized	specialized	JJ
cord-006229-7yoilsho	4531	13	niches	niche	NNS
cord-006229-7yoilsho	4531	14	in	in	IN
cord-006229-7yoilsho	4531	15	the	the	DT
cord-006229-7yoilsho	4531	16	intestinal	intestinal	JJ
cord-006229-7yoilsho	4531	17	crypts	crypt	NNS
cord-006229-7yoilsho	4531	18	and	and	CC
cord-006229-7yoilsho	4531	19	give	give	VB
cord-006229-7yoilsho	4531	20	rise	rise	NN
cord-006229-7yoilsho	4531	21	to	to	IN
cord-006229-7yoilsho	4531	22	several	several	JJ
cord-006229-7yoilsho	4531	23	differentiated	differentiated	JJ
cord-006229-7yoilsho	4531	24	cell	cell	NN
cord-006229-7yoilsho	4531	25	types	type	NNS
cord-006229-7yoilsho	4531	26	,	,	,
cord-006229-7yoilsho	4531	27	including	include	VBG
cord-006229-7yoilsho	4531	28	enterocytes	enterocyte	NNS
cord-006229-7yoilsho	4531	29	,	,	,
cord-006229-7yoilsho	4531	30	Paneth	Paneth	NNP
cord-006229-7yoilsho	4531	31	,	,	,
cord-006229-7yoilsho	4531	32	enteroendocrine	enteroendocrine	NNP
cord-006229-7yoilsho	4531	33	,	,	,
cord-006229-7yoilsho	4531	34	goblet	goblet	NN
cord-006229-7yoilsho	4531	35	and	and	CC
cord-006229-7yoilsho	4531	36	Tuft	tuft	NN
cord-006229-7yoilsho	4531	37	cells	cell	NNS
cord-006229-7yoilsho	4531	38	.	.	.
cord-006229-7yoilsho	4532	1	However	however	RB
cord-006229-7yoilsho	4532	2	,	,	,
cord-006229-7yoilsho	4532	3	the	the	DT
cord-006229-7yoilsho	4532	4	molecular	molecular	JJ
cord-006229-7yoilsho	4532	5	mechanisms	mechanism	NNS
cord-006229-7yoilsho	4532	6	that	that	WDT
cord-006229-7yoilsho	4532	7	establish	establish	VBP
cord-006229-7yoilsho	4532	8	and	and	CC
cord-006229-7yoilsho	4532	9	maintain	maintain	VB
cord-006229-7yoilsho	4532	10	differentiated	differentiated	JJ
cord-006229-7yoilsho	4532	11	cell	cell	NN
cord-006229-7yoilsho	4532	12	numbers	number	NNS
cord-006229-7yoilsho	4532	13	and	and	CC
cord-006229-7yoilsho	4532	14	proportions	proportion	NNS
cord-006229-7yoilsho	4532	15	remain	remain	VBP
cord-006229-7yoilsho	4532	16	largely	largely	RB
cord-006229-7yoilsho	4532	17	unknown	unknown	JJ
cord-006229-7yoilsho	4532	18	.	.	.
cord-006229-7yoilsho	4533	1	Here	here	RB
cord-006229-7yoilsho	4533	2	,	,	,
cord-006229-7yoilsho	4533	3	we	-PRON-	PRP
cord-006229-7yoilsho	4533	4	systematically	systematically	RB
cord-006229-7yoilsho	4533	5	analyzed	analyze	VBD
cord-006229-7yoilsho	4533	6	the	the	DT
cord-006229-7yoilsho	4533	7	intestinal	intestinal	JJ
cord-006229-7yoilsho	4533	8	expression	expression	NN
cord-006229-7yoilsho	4533	9	of	of	IN
cord-006229-7yoilsho	4533	10	semaphorins	semaphorin	NNS
cord-006229-7yoilsho	4533	11	and	and	CC
cord-006229-7yoilsho	4533	12	plexins	plexin	NNS
cord-006229-7yoilsho	4533	13	,	,	,
cord-006229-7yoilsho	4533	14	which	which	WDT
cord-006229-7yoilsho	4533	15	constitute	constitute	VBP
cord-006229-7yoilsho	4533	16	a	a	DT
cord-006229-7yoilsho	4533	17	ligand	ligand	NN
cord-006229-7yoilsho	4533	18	-	-	HYPH
cord-006229-7yoilsho	4533	19	receptor	receptor	NN
cord-006229-7yoilsho	4533	20	system	system	NN
cord-006229-7yoilsho	4533	21	that	that	WDT
cord-006229-7yoilsho	4533	22	plays	play	VBZ
cord-006229-7yoilsho	4533	23	central	central	JJ
cord-006229-7yoilsho	4533	24	roles	role	NNS
cord-006229-7yoilsho	4533	25	in	in	IN
cord-006229-7yoilsho	4533	26	cell	cell	NN
cord-006229-7yoilsho	4533	27	-	-	HYPH
cord-006229-7yoilsho	4533	28	cell	cell	NN
cord-006229-7yoilsho	4533	29	communication	communication	NN
cord-006229-7yoilsho	4533	30	in	in	IN
cord-006229-7yoilsho	4533	31	various	various	JJ
cord-006229-7yoilsho	4533	32	biological	biological	JJ
cord-006229-7yoilsho	4533	33	contexts	context	NNS
cord-006229-7yoilsho	4533	34	.	.	.
cord-006229-7yoilsho	4534	1	We	-PRON-	PRP
cord-006229-7yoilsho	4534	2	identified	identify	VBD
cord-006229-7yoilsho	4534	3	Plexin	Plexin	NNP
cord-006229-7yoilsho	4534	4	-	-	HYPH
cord-006229-7yoilsho	4534	5	B2	b2	NN
cord-006229-7yoilsho	4534	6	and	and	CC
cord-006229-7yoilsho	4534	7	its	-PRON-	PRP$
cord-006229-7yoilsho	4534	8	semaphorin	semaphorin	JJ
cord-006229-7yoilsho	4534	9	ligands	ligand	NNS
cord-006229-7yoilsho	4534	10	to	to	TO
cord-006229-7yoilsho	4534	11	be	be	VB
cord-006229-7yoilsho	4534	12	highly	highly	RB
cord-006229-7yoilsho	4534	13	expressed	express	VBN
cord-006229-7yoilsho	4534	14	in	in	IN
cord-006229-7yoilsho	4534	15	intestinal	intestinal	JJ
cord-006229-7yoilsho	4534	16	epithelial	epithelial	JJ
cord-006229-7yoilsho	4534	17	cells	cell	NNS
cord-006229-7yoilsho	4534	18	.	.	.
cord-006229-7yoilsho	4535	1	Genetic	genetic	JJ
cord-006229-7yoilsho	4535	2	inactivation	inactivation	NN
cord-006229-7yoilsho	4535	3	of	of	IN
cord-006229-7yoilsho	4535	4	Plexin	Plexin	NNP
cord-006229-7yoilsho	4535	5	-	-	HYPH
cord-006229-7yoilsho	4535	6	B2	b2	NN
cord-006229-7yoilsho	4535	7	in	in	IN
cord-006229-7yoilsho	4535	8	intestinal	intestinal	JJ
cord-006229-7yoilsho	4535	9	organoids	organoid	NNS
cord-006229-7yoilsho	4535	10	strongly	strongly	RB
cord-006229-7yoilsho	4535	11	reduced	reduce	VBD
cord-006229-7yoilsho	4535	12	the	the	DT
cord-006229-7yoilsho	4535	13	number	number	NN
cord-006229-7yoilsho	4535	14	of	of	IN
cord-006229-7yoilsho	4535	15	enteroendocrine	enteroendocrine	JJ
cord-006229-7yoilsho	4535	16	cells	cell	NNS
cord-006229-7yoilsho	4535	17	.	.	.
cord-006229-7yoilsho	4536	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	4536	2	data	datum	NNS
cord-006229-7yoilsho	4536	3	suggest	suggest	VBP
cord-006229-7yoilsho	4536	4	that	that	IN
cord-006229-7yoilsho	4536	5	semaphorin	semaphorin	JJ
cord-006229-7yoilsho	4536	6	-	-	HYPH
cord-006229-7yoilsho	4536	7	Plexin	Plexin	NNP
cord-006229-7yoilsho	4536	8	-	-	HYPH
cord-006229-7yoilsho	4536	9	B2	b2	NN
cord-006229-7yoilsho	4536	10	signaling	signaling	NN
cord-006229-7yoilsho	4536	11	promotes	promote	VBZ
cord-006229-7yoilsho	4536	12	differentiation	differentiation	NN
cord-006229-7yoilsho	4536	13	of	of	IN
cord-006229-7yoilsho	4536	14	intestinal	intestinal	JJ
cord-006229-7yoilsho	4536	15	epithelial	epithelial	JJ
cord-006229-7yoilsho	4536	16	cells	cell	NNS
cord-006229-7yoilsho	4536	17	towards	towards	IN
cord-006229-7yoilsho	4536	18	the	the	DT
cord-006229-7yoilsho	4536	19	enteroendocrine	enteroendocrine	NNP
cord-006229-7yoilsho	4536	20	lineage	lineage	NN
cord-006229-7yoilsho	4536	21	.	.	.
cord-006229-7yoilsho	4537	1	The	the	DT
cord-006229-7yoilsho	4537	2	gastric	gastric	JJ
cord-006229-7yoilsho	4537	3	epithelium	epithelium	NN
cord-006229-7yoilsho	4537	4	contains	contain	VBZ
cord-006229-7yoilsho	4537	5	several	several	JJ
cord-006229-7yoilsho	4537	6	types	type	NNS
cord-006229-7yoilsho	4537	7	of	of	IN
cord-006229-7yoilsho	4537	8	differentiated	differentiated	JJ
cord-006229-7yoilsho	4537	9	cells	cell	NNS
cord-006229-7yoilsho	4537	10	,	,	,
cord-006229-7yoilsho	4537	11	including	include	VBG
cord-006229-7yoilsho	4537	12	foveolar	foveolar	JJ
cord-006229-7yoilsho	4537	13	cells	cell	NNS
cord-006229-7yoilsho	4537	14	that	that	WDT
cord-006229-7yoilsho	4537	15	produce	produce	VBP
cord-006229-7yoilsho	4537	16	mucus	mucus	NN
cord-006229-7yoilsho	4537	17	,	,	,
cord-006229-7yoilsho	4537	18	parietal	parietal	JJ
cord-006229-7yoilsho	4537	19	cells	cell	NNS
cord-006229-7yoilsho	4537	20	that	that	WDT
cord-006229-7yoilsho	4537	21	secrete	secrete	VBP
cord-006229-7yoilsho	4537	22	gastric	gastric	JJ
cord-006229-7yoilsho	4537	23	acid	acid	NN
cord-006229-7yoilsho	4537	24	and	and	CC
cord-006229-7yoilsho	4537	25	intrinsic	intrinsic	JJ
cord-006229-7yoilsho	4537	26	factor	factor	NN
cord-006229-7yoilsho	4537	27	,	,	,
cord-006229-7yoilsho	4537	28	chief	chief	NN
cord-006229-7yoilsho	4537	29	cells	cell	NNS
cord-006229-7yoilsho	4537	30	that	that	WDT
cord-006229-7yoilsho	4537	31	synthesize	synthesize	VBP
cord-006229-7yoilsho	4537	32	pepsinogen	pepsinogen	NN
cord-006229-7yoilsho	4537	33	and	and	CC
cord-006229-7yoilsho	4537	34	gastric	gastric	JJ
cord-006229-7yoilsho	4537	35	lipase	lipase	NN
cord-006229-7yoilsho	4537	36	,	,	,
cord-006229-7yoilsho	4537	37	and	and	CC
cord-006229-7yoilsho	4537	38	enteroendocrine	enteroendocrine	JJ
cord-006229-7yoilsho	4537	39	cells	cell	NNS
cord-006229-7yoilsho	4537	40	that	that	WDT
cord-006229-7yoilsho	4537	41	release	release	VBP
cord-006229-7yoilsho	4537	42	different	different	JJ
cord-006229-7yoilsho	4537	43	hormones	hormone	NNS
cord-006229-7yoilsho	4537	44	.	.	.
cord-006229-7yoilsho	4538	1	These	these	DT
cord-006229-7yoilsho	4538	2	differentiated	differentiate	VBN
cord-006229-7yoilsho	4538	3	cell	cell	NN
cord-006229-7yoilsho	4538	4	types	type	NNS
cord-006229-7yoilsho	4538	5	all	all	DT
cord-006229-7yoilsho	4538	6	originate	originate	VBP
cord-006229-7yoilsho	4538	7	from	from	IN
cord-006229-7yoilsho	4538	8	multipotent	multipotent	JJ
cord-006229-7yoilsho	4538	9	stem	stem	NN
cord-006229-7yoilsho	4538	10	cells	cell	NNS
cord-006229-7yoilsho	4538	11	,	,	,
cord-006229-7yoilsho	4538	12	yet	yet	CC
cord-006229-7yoilsho	4538	13	little	little	JJ
cord-006229-7yoilsho	4538	14	is	be	VBZ
cord-006229-7yoilsho	4538	15	known	know	VBN
cord-006229-7yoilsho	4538	16	about	about	IN
cord-006229-7yoilsho	4538	17	how	how	WRB
cord-006229-7yoilsho	4538	18	this	this	DT
cord-006229-7yoilsho	4538	19	differentiation	differentiation	NN
cord-006229-7yoilsho	4538	20	process	process	NN
cord-006229-7yoilsho	4538	21	is	be	VBZ
cord-006229-7yoilsho	4538	22	regulated	regulate	VBN
cord-006229-7yoilsho	4538	23	on	on	IN
cord-006229-7yoilsho	4538	24	a	a	DT
cord-006229-7yoilsho	4538	25	molecular	molecular	JJ
cord-006229-7yoilsho	4538	26	level	level	NN
cord-006229-7yoilsho	4538	27	.	.	.
cord-006229-7yoilsho	4539	1	The	the	DT
cord-006229-7yoilsho	4539	2	GAP	gap	NN
cord-006229-7yoilsho	4539	3	protein	protein	NN
cord-006229-7yoilsho	4539	4	Rasal1	Rasal1	NNP
cord-006229-7yoilsho	4539	5	controls	control	VBZ
cord-006229-7yoilsho	4539	6	the	the	DT
cord-006229-7yoilsho	4539	7	activity	activity	NN
cord-006229-7yoilsho	4539	8	of	of	IN
cord-006229-7yoilsho	4539	9	small	small	JJ
cord-006229-7yoilsho	4539	10	GTPases	gtpase	NNS
cord-006229-7yoilsho	4539	11	of	of	IN
cord-006229-7yoilsho	4539	12	the	the	DT
cord-006229-7yoilsho	4539	13	Ras	Ras	NNP
cord-006229-7yoilsho	4539	14	family	family	NN
cord-006229-7yoilsho	4539	15	,	,	,
cord-006229-7yoilsho	4539	16	and	and	CC
cord-006229-7yoilsho	4539	17	its	-PRON-	PRP$
cord-006229-7yoilsho	4539	18	expression	expression	NN
cord-006229-7yoilsho	4539	19	levels	level	NNS
cord-006229-7yoilsho	4539	20	have	have	VBP
cord-006229-7yoilsho	4539	21	been	be	VBN
cord-006229-7yoilsho	4539	22	shown	show	VBN
cord-006229-7yoilsho	4539	23	to	to	TO
cord-006229-7yoilsho	4539	24	inversely	inversely	RB
cord-006229-7yoilsho	4539	25	correlate	correlate	VB
cord-006229-7yoilsho	4539	26	with	with	IN
cord-006229-7yoilsho	4539	27	progression	progression	NN
cord-006229-7yoilsho	4539	28	of	of	IN
cord-006229-7yoilsho	4539	29	stomach	stomach	NN
cord-006229-7yoilsho	4539	30	cancers	cancer	NNS
cord-006229-7yoilsho	4539	31	.	.	.
cord-006229-7yoilsho	4540	1	However	however	RB
cord-006229-7yoilsho	4540	2	,	,	,
cord-006229-7yoilsho	4540	3	functional	functional	JJ
cord-006229-7yoilsho	4540	4	studies	study	NNS
cord-006229-7yoilsho	4540	5	on	on	IN
cord-006229-7yoilsho	4540	6	the	the	DT
cord-006229-7yoilsho	4540	7	physiological	physiological	JJ
cord-006229-7yoilsho	4540	8	role	role	NN
cord-006229-7yoilsho	4540	9	of	of	IN
cord-006229-7yoilsho	4540	10	Rasal1	Rasal1	NNP
cord-006229-7yoilsho	4541	1	in	in	IN
cord-006229-7yoilsho	4541	2	the	the	DT
cord-006229-7yoilsho	4541	3	gastric	gastric	JJ
cord-006229-7yoilsho	4541	4	epithelium	epithelium	NN
cord-006229-7yoilsho	4541	5	are	be	VBP
cord-006229-7yoilsho	4541	6	lacking	lack	VBG
cord-006229-7yoilsho	4541	7	.	.	.
cord-006229-7yoilsho	4542	1	Here	here	RB
cord-006229-7yoilsho	4542	2	,	,	,
cord-006229-7yoilsho	4542	3	we	-PRON-	PRP
cord-006229-7yoilsho	4542	4	established	establish	VBD
cord-006229-7yoilsho	4542	5	and	and	CC
cord-006229-7yoilsho	4542	6	characterized	characterize	VBD
cord-006229-7yoilsho	4542	7	a	a	DT
cord-006229-7yoilsho	4542	8	mouse	mouse	NN
cord-006229-7yoilsho	4542	9	line	line	NN
cord-006229-7yoilsho	4542	10	with	with	IN
cord-006229-7yoilsho	4542	11	inactivation	inactivation	NN
cord-006229-7yoilsho	4542	12	of	of	IN
cord-006229-7yoilsho	4542	13	the	the	DT
cord-006229-7yoilsho	4542	14	Rasal1	Rasal1	NNP
cord-006229-7yoilsho	4542	15	gene	gene	NN
cord-006229-7yoilsho	4542	16	.	.	.
cord-006229-7yoilsho	4543	1	We	-PRON-	PRP
cord-006229-7yoilsho	4543	2	observed	observe	VBD
cord-006229-7yoilsho	4543	3	that	that	IN
cord-006229-7yoilsho	4543	4	these	these	DT
cord-006229-7yoilsho	4543	5	mice	mouse	NNS
cord-006229-7yoilsho	4543	6	showed	show	VBD
cord-006229-7yoilsho	4543	7	increased	increase	VBN
cord-006229-7yoilsho	4543	8	numbers	number	NNS
cord-006229-7yoilsho	4543	9	of	of	IN
cord-006229-7yoilsho	4543	10	enteroendocrine	enteroendocrine	JJ
cord-006229-7yoilsho	4543	11	cells	cell	NNS
cord-006229-7yoilsho	4543	12	in	in	IN
cord-006229-7yoilsho	4543	13	the	the	DT
cord-006229-7yoilsho	4543	14	gastric	gastric	JJ
cord-006229-7yoilsho	4543	15	mucosa	mucosa	NN
cord-006229-7yoilsho	4543	16	.	.	.
cord-006229-7yoilsho	4544	1	Conditional	conditional	JJ
cord-006229-7yoilsho	4544	2	inactivation	inactivation	NN
cord-006229-7yoilsho	4544	3	of	of	IN
cord-006229-7yoilsho	4544	4	Rasal1	Rasal1	NNPS
cord-006229-7yoilsho	4544	5	in	in	IN
cord-006229-7yoilsho	4544	6	enteroendocrine	enteroendocrine	JJ
cord-006229-7yoilsho	4544	7	cells	cell	NNS
cord-006229-7yoilsho	4544	8	,	,	,
cord-006229-7yoilsho	4544	9	using	use	VBG
cord-006229-7yoilsho	4544	10	a	a	DT
cord-006229-7yoilsho	4544	11	mouse	mouse	NN
cord-006229-7yoilsho	4544	12	line	line	NN
cord-006229-7yoilsho	4544	13	in	in	IN
cord-006229-7yoilsho	4544	14	which	which	WDT
cord-006229-7yoilsho	4544	15	Cre	cre	JJ
cord-006229-7yoilsho	4544	16	expression	expression	NN
cord-006229-7yoilsho	4544	17	is	be	VBZ
cord-006229-7yoilsho	4544	18	driven	drive	VBN
cord-006229-7yoilsho	4544	19	by	by	IN
cord-006229-7yoilsho	4544	20	the	the	DT
cord-006229-7yoilsho	4544	21	Atoh1	atoh1	JJ
cord-006229-7yoilsho	4544	22	promoter	promoter	NN
cord-006229-7yoilsho	4544	23	,	,	,
cord-006229-7yoilsho	4544	24	further	further	RB
cord-006229-7yoilsho	4544	25	corroborated	corroborate	VBD
cord-006229-7yoilsho	4544	26	that	that	IN
cord-006229-7yoilsho	4544	27	Rasal1	Rasal1	NNP
cord-006229-7yoilsho	4544	28	expression	expression	NN
cord-006229-7yoilsho	4544	29	in	in	IN
cord-006229-7yoilsho	4544	30	enteroendocrine	enteroendocrine	NNP
cord-006229-7yoilsho	4544	31	cells	cell	NNS
cord-006229-7yoilsho	4544	32	determines	determine	VBZ
cord-006229-7yoilsho	4544	33	enteroendocrine	enteroendocrine	JJ
cord-006229-7yoilsho	4544	34	cell	cell	NN
cord-006229-7yoilsho	4544	35	numbers	number	NNS
cord-006229-7yoilsho	4544	36	.	.	.
cord-006229-7yoilsho	4545	1	These	these	DT
cord-006229-7yoilsho	4545	2	findings	finding	NNS
cord-006229-7yoilsho	4545	3	identify	identify	VBP
cord-006229-7yoilsho	4545	4	Rasal1	Rasal1	NNP
cord-006229-7yoilsho	4546	1	as	as	IN
cord-006229-7yoilsho	4546	2	a	a	DT
cord-006229-7yoilsho	4546	3	regulator	regulator	NN
cord-006229-7yoilsho	4546	4	of	of	IN
cord-006229-7yoilsho	4546	5	gastric	gastric	JJ
cord-006229-7yoilsho	4546	6	epithelial	epithelial	JJ
cord-006229-7yoilsho	4546	7	cell	cell	NN
cord-006229-7yoilsho	4546	8	differentiation	differentiation	NN
cord-006229-7yoilsho	4546	9	.	.	.
cord-006229-7yoilsho	4546	10	)	)	-RRB-
cord-006229-7yoilsho	4546	11	.	.	.
cord-006229-7yoilsho	4547	1	The	the	DT
cord-006229-7yoilsho	4547	2	present	present	JJ
cord-006229-7yoilsho	4547	3	study	study	NN
cord-006229-7yoilsho	4547	4	investigates	investigate	VBZ
cord-006229-7yoilsho	4547	5	the	the	DT
cord-006229-7yoilsho	4547	6	impact	impact	NN
cord-006229-7yoilsho	4547	7	of	of	IN
cord-006229-7yoilsho	4547	8	two	two	CD
cord-006229-7yoilsho	4547	9	FAAH	FAAH	NNP
cord-006229-7yoilsho	4547	10	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	4547	11	(	(	-LRB-
cord-006229-7yoilsho	4547	12	arachidonoyl	arachidonoyl	JJ
cord-006229-7yoilsho	4547	13	serotonin	serotonin	NN
cord-006229-7yoilsho	4547	14	[	[	-LRB-
cord-006229-7yoilsho	4547	15	AA-5HT	AA-5HT	NNP
cord-006229-7yoilsho	4547	16	]	]	-RRB-
cord-006229-7yoilsho	4547	17	,	,	,
cord-006229-7yoilsho	4547	18	URB597	URB597	NNP
cord-006229-7yoilsho	4547	19	)	)	-RRB-
cord-006229-7yoilsho	4547	20	on	on	IN
cord-006229-7yoilsho	4547	21	A549	a549	JJ
cord-006229-7yoilsho	4547	22	lung	lung	NN
cord-006229-7yoilsho	4547	23	cancer	cancer	NN
cord-006229-7yoilsho	4547	24	cell	cell	NN
cord-006229-7yoilsho	4547	25	metastasis	metastasis	NN
cord-006229-7yoilsho	4547	26	and	and	CC
cord-006229-7yoilsho	4547	27	invasion	invasion	NN
cord-006229-7yoilsho	4547	28	.	.	.
cord-006229-7yoilsho	4548	1	LC	LC	NNP
cord-006229-7yoilsho	4548	2	-	-	HYPH
cord-006229-7yoilsho	4548	3	MS	MS	NNP
cord-006229-7yoilsho	4548	4	analyses	analysis	NNS
cord-006229-7yoilsho	4548	5	revealed	reveal	VBD
cord-006229-7yoilsho	4548	6	increased	increase	VBN
cord-006229-7yoilsho	4548	7	levels	level	NNS
cord-006229-7yoilsho	4548	8	of	of	IN
cord-006229-7yoilsho	4548	9	FAAH	FAAH	NNP
cord-006229-7yoilsho	4548	10	substrates	substrate	NNS
cord-006229-7yoilsho	4548	11	(	(	-LRB-
cord-006229-7yoilsho	4548	12	AEA	AEA	NNP
cord-006229-7yoilsho	4548	13	,	,	,
cord-006229-7yoilsho	4548	14	2-AG	2-ag	CD
cord-006229-7yoilsho	4548	15	,	,	,
cord-006229-7yoilsho	4548	16	OEA	OEA	NNP
cord-006229-7yoilsho	4548	17	,	,	,
cord-006229-7yoilsho	4548	18	PEA	PEA	NNP
cord-006229-7yoilsho	4548	19	)	)	-RRB-
cord-006229-7yoilsho	4548	20	in	in	IN
cord-006229-7yoilsho	4548	21	cells	cell	NNS
cord-006229-7yoilsho	4548	22	incubated	incubate	VBN
cord-006229-7yoilsho	4548	23	with	with	IN
cord-006229-7yoilsho	4548	24	either	either	CC
cord-006229-7yoilsho	4548	25	FAAH	FAAH	NNP
cord-006229-7yoilsho	4548	26	inhibitor	inhibitor	NN
cord-006229-7yoilsho	4548	27	.	.	.
cord-006229-7yoilsho	4549	1	In	in	IN
cord-006229-7yoilsho	4549	2	athymic	athymic	JJ
cord-006229-7yoilsho	4549	3	nude	nude	JJ
cord-006229-7yoilsho	4549	4	mice	mouse	NNS
cord-006229-7yoilsho	4549	5	FAAH	FAAH	NNP
cord-006229-7yoilsho	4549	6	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	4549	7	were	be	VBD
cord-006229-7yoilsho	4549	8	shown	show	VBN
cord-006229-7yoilsho	4549	9	to	to	TO
cord-006229-7yoilsho	4549	10	elicit	elicit	VB
cord-006229-7yoilsho	4549	11	a	a	DT
cord-006229-7yoilsho	4549	12	dosedependent	dosedependent	NN
cord-006229-7yoilsho	4549	13	antimetastatic	antimetastatic	JJ
cord-006229-7yoilsho	4549	14	action	action	NN
cord-006229-7yoilsho	4549	15	.	.	.
cord-006229-7yoilsho	4550	1	In	in	IN
cord-006229-7yoilsho	4550	2	vitro	vitro	FW
cord-006229-7yoilsho	4550	3	,	,	,
cord-006229-7yoilsho	4550	4	a	a	DT
cord-006229-7yoilsho	4550	5	concentration	concentration	NN
cord-006229-7yoilsho	4550	6	-	-	HYPH
cord-006229-7yoilsho	4550	7	dependent	dependent	JJ
cord-006229-7yoilsho	4550	8	anti	anti	JJ
cord-006229-7yoilsho	4550	9	-	-	JJ
cord-006229-7yoilsho	4550	10	invasive	invasive	JJ
cord-006229-7yoilsho	4550	11	action	action	NN
cord-006229-7yoilsho	4550	12	of	of	IN
cord-006229-7yoilsho	4550	13	either	either	CC
cord-006229-7yoilsho	4550	14	FAAH	FAAH	NNP
cord-006229-7yoilsho	4550	15	inhibitor	inhibitor	NN
cord-006229-7yoilsho	4550	16	was	be	VBD
cord-006229-7yoilsho	4550	17	demonstrated	demonstrate	VBN
cord-006229-7yoilsho	4550	18	,	,	,
cord-006229-7yoilsho	4550	19	accompanied	accompany	VBN
cord-006229-7yoilsho	4550	20	with	with	IN
cord-006229-7yoilsho	4550	21	upregulation	upregulation	NN
cord-006229-7yoilsho	4550	22	of	of	IN
cord-006229-7yoilsho	4550	23	tissue	tissue	NN
cord-006229-7yoilsho	4550	24	inhibitor	inhibitor	NN
cord-006229-7yoilsho	4550	25	of	of	IN
cord-006229-7yoilsho	4550	26	matrix	matrix	NN
cord-006229-7yoilsho	4550	27	metalloproteinases-1	metalloproteinases-1	NNP
cord-006229-7yoilsho	4550	28	(	(	-LRB-
cord-006229-7yoilsho	4550	29	TIMP-1	TIMP-1	NNP
cord-006229-7yoilsho	4550	30	)	)	-RRB-
cord-006229-7yoilsho	4550	31	.	.	.
cord-006229-7yoilsho	4551	1	Using	use	VBG
cord-006229-7yoilsho	4551	2	siRNA	siRNA	NNP
cord-006229-7yoilsho	4551	3	approaches	approach	NNS
cord-006229-7yoilsho	4551	4	,	,	,
cord-006229-7yoilsho	4551	5	a	a	DT
cord-006229-7yoilsho	4551	6	causal	causal	JJ
cord-006229-7yoilsho	4551	7	link	link	NN
cord-006229-7yoilsho	4551	8	between	between	IN
cord-006229-7yoilsho	4551	9	the	the	DT
cord-006229-7yoilsho	4551	10	TIMP-1-upregulating	timp-1-upregulating	NN
cord-006229-7yoilsho	4551	11	and	and	CC
cord-006229-7yoilsho	4551	12	anti	anti	JJ
cord-006229-7yoilsho	4551	13	-	-	JJ
cord-006229-7yoilsho	4551	14	invasive	invasive	JJ
cord-006229-7yoilsho	4551	15	action	action	NN
cord-006229-7yoilsho	4551	16	of	of	IN
cord-006229-7yoilsho	4551	17	FAAH	FAAH	NNP
cord-006229-7yoilsho	4551	18	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	4551	19	was	be	VBD
cord-006229-7yoilsho	4551	20	confirmed	confirm	VBN
cord-006229-7yoilsho	4551	21	.	.	.
cord-006229-7yoilsho	4552	1	Moreover	moreover	RB
cord-006229-7yoilsho	4552	2	,	,	,
cord-006229-7yoilsho	4552	3	knockdown	knockdown	NN
cord-006229-7yoilsho	4552	4	of	of	IN
cord-006229-7yoilsho	4552	5	FAAH	FAAH	NNP
cord-006229-7yoilsho	4552	6	by	by	IN
cord-006229-7yoilsho	4552	7	siRNA	siRNA	NNP
cord-006229-7yoilsho	4552	8	was	be	VBD
cord-006229-7yoilsho	4552	9	shown	show	VBN
cord-006229-7yoilsho	4552	10	to	to	TO
cord-006229-7yoilsho	4552	11	confer	confer	VB
cord-006229-7yoilsho	4552	12	decreased	decreased	JJ
cord-006229-7yoilsho	4552	13	cancer	cancer	NN
cord-006229-7yoilsho	4552	14	cell	cell	NN
cord-006229-7yoilsho	4552	15	invasiveness	invasiveness	NN
cord-006229-7yoilsho	4552	16	and	and	CC
cord-006229-7yoilsho	4552	17	increased	increase	VBN
cord-006229-7yoilsho	4552	18	TIMP-1	TIMP-1	NNP
cord-006229-7yoilsho	4552	19	expression	expression	NN
cord-006229-7yoilsho	4552	20	.	.	.
cord-006229-7yoilsho	4553	1	Inhibitor	inhibitor	NN
cord-006229-7yoilsho	4553	2	experiments	experiment	NNS
cord-006229-7yoilsho	4553	3	point	point	VBP
cord-006229-7yoilsho	4553	4	toward	toward	IN
cord-006229-7yoilsho	4553	5	a	a	DT
cord-006229-7yoilsho	4553	6	decisive	decisive	JJ
cord-006229-7yoilsho	4553	7	role	role	NN
cord-006229-7yoilsho	4553	8	of	of	IN
cord-006229-7yoilsho	4553	9	CB	CB	NNP
cord-006229-7yoilsho	4553	10	2	2	CD
cord-006229-7yoilsho	4553	11	and	and	CC
cord-006229-7yoilsho	4553	12	transient	transient	JJ
cord-006229-7yoilsho	4553	13	receptor	receptor	NN
cord-006229-7yoilsho	4553	14	potential	potential	JJ
cord-006229-7yoilsho	4553	15	vanilloid	vanilloid	NNP
cord-006229-7yoilsho	4553	16	1	1	CD
cord-006229-7yoilsho	4553	17	in	in	IN
cord-006229-7yoilsho	4553	18	conferring	confer	VBG
cord-006229-7yoilsho	4553	19	the	the	DT
cord-006229-7yoilsho	4553	20	anti	anti	JJ
cord-006229-7yoilsho	4553	21	-	-	JJ
cord-006229-7yoilsho	4553	22	invasive	invasive	JJ
cord-006229-7yoilsho	4553	23	effects	effect	NNS
cord-006229-7yoilsho	4553	24	of	of	IN
cord-006229-7yoilsho	4553	25	FAAH	FAAH	NNP
cord-006229-7yoilsho	4553	26	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	4553	27	and	and	CC
cord-006229-7yoilsho	4553	28	FAAH	FAAH	NNP
cord-006229-7yoilsho	4553	29	siRNA	siRNA	NNP
cord-006229-7yoilsho	4553	30	.	.	.
cord-006229-7yoilsho	4554	1	Finally	finally	RB
cord-006229-7yoilsho	4554	2	,	,	,
cord-006229-7yoilsho	4554	3	antimetastatic	antimetastatic	JJ
cord-006229-7yoilsho	4554	4	and	and	CC
cord-006229-7yoilsho	4554	5	anti	anti	JJ
cord-006229-7yoilsho	4554	6	-	-	JJ
cord-006229-7yoilsho	4554	7	invasive	invasive	JJ
cord-006229-7yoilsho	4554	8	effects	effect	NNS
cord-006229-7yoilsho	4554	9	were	be	VBD
cord-006229-7yoilsho	4554	10	confirmed	confirm	VBN
cord-006229-7yoilsho	4554	11	for	for	IN
cord-006229-7yoilsho	4554	12	all	all	DT
cord-006229-7yoilsho	4554	13	FAAH	FAAH	NNP
cord-006229-7yoilsho	4554	14	substrates	substrate	NNS
cord-006229-7yoilsho	4554	15	.	.	.
cord-006229-7yoilsho	4555	1	Collectively	collectively	RB
cord-006229-7yoilsho	4555	2	,	,	,
cord-006229-7yoilsho	4555	3	the	the	DT
cord-006229-7yoilsho	4555	4	present	present	JJ
cord-006229-7yoilsho	4555	5	study	study	NN
cord-006229-7yoilsho	4555	6	provides	provide	VBZ
cord-006229-7yoilsho	4555	7	first	first	JJ
cord-006229-7yoilsho	4555	8	-	-	HYPH
cord-006229-7yoilsho	4555	9	time	time	NN
cord-006229-7yoilsho	4555	10	proof	proof	NN
cord-006229-7yoilsho	4555	11	for	for	IN
cord-006229-7yoilsho	4555	12	a	a	DT
cord-006229-7yoilsho	4555	13	pronounced	pronounce	VBN
cord-006229-7yoilsho	4555	14	antimetastatic	antimetastatic	JJ
cord-006229-7yoilsho	4555	15	action	action	NN
cord-006229-7yoilsho	4555	16	of	of	IN
cord-006229-7yoilsho	4555	17	the	the	DT
cord-006229-7yoilsho	4555	18	FAAH	FAAH	NNP
cord-006229-7yoilsho	4555	19	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	4555	20	AA-5HT	aa-5ht	NN
cord-006229-7yoilsho	4555	21	and	and	CC
cord-006229-7yoilsho	4555	22	URB597	URB597	NNP
cord-006229-7yoilsho	4555	23	.	.	.
cord-006229-7yoilsho	4556	1	As	as	IN
cord-006229-7yoilsho	4556	2	underlying	underlying	JJ
cord-006229-7yoilsho	4556	3	mechanism	mechanism	NN
cord-006229-7yoilsho	4556	4	of	of	IN
cord-006229-7yoilsho	4556	5	its	-PRON-	PRP$
cord-006229-7yoilsho	4556	6	anti	anti	JJ
cord-006229-7yoilsho	4556	7	-	-	JJ
cord-006229-7yoilsho	4556	8	invasive	invasive	JJ
cord-006229-7yoilsho	4556	9	properties	property	NNS
cord-006229-7yoilsho	4556	10	an	an	DT
cord-006229-7yoilsho	4556	11	upregulation	upregulation	NN
cord-006229-7yoilsho	4556	12	of	of	IN
cord-006229-7yoilsho	4556	13	TIMP-1	TIMP-1	NNP
cord-006229-7yoilsho	4556	14	was	be	VBD
cord-006229-7yoilsho	4556	15	identified	identify	VBN
cord-006229-7yoilsho	4556	16	.	.	.
cord-006229-7yoilsho	4557	1	Regenerative	regenerative	JJ
cord-006229-7yoilsho	4557	2	activity	activity	NN
cord-006229-7yoilsho	4557	3	in	in	IN
cord-006229-7yoilsho	4557	4	tissues	tissue	NNS
cord-006229-7yoilsho	4557	5	of	of	IN
cord-006229-7yoilsho	4557	6	mesenchymal	mesenchymal	JJ
cord-006229-7yoilsho	4557	7	origin	origin	NN
cord-006229-7yoilsho	4557	8	depends	depend	VBZ
cord-006229-7yoilsho	4557	9	on	on	IN
cord-006229-7yoilsho	4557	10	the	the	DT
cord-006229-7yoilsho	4557	11	migratory	migratory	JJ
cord-006229-7yoilsho	4557	12	potential	potential	NN
cord-006229-7yoilsho	4557	13	of	of	IN
cord-006229-7yoilsho	4557	14	mesenchymal	mesenchymal	JJ
cord-006229-7yoilsho	4557	15	stem	stem	NN
cord-006229-7yoilsho	4557	16	cells	cell	NNS
cord-006229-7yoilsho	4557	17	(	(	-LRB-
cord-006229-7yoilsho	4557	18	MSCs	msc	NNS
cord-006229-7yoilsho	4557	19	)	)	-RRB-
cord-006229-7yoilsho	4557	20	.	.	.
cord-006229-7yoilsho	4558	1	The	the	DT
cord-006229-7yoilsho	4558	2	present	present	JJ
cord-006229-7yoilsho	4558	3	study	study	NN
cord-006229-7yoilsho	4558	4	focused	focus	VBD
cord-006229-7yoilsho	4558	5	on	on	IN
cord-006229-7yoilsho	4558	6	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	4558	7	of	of	IN
cord-006229-7yoilsho	4558	8	the	the	DT
cord-006229-7yoilsho	4558	9	enzyme	enzyme	JJ
cord-006229-7yoilsho	4558	10	fatty	fatty	JJ
cord-006229-7yoilsho	4558	11	acid	acid	NN
cord-006229-7yoilsho	4558	12	amide	amide	NN
cord-006229-7yoilsho	4558	13	hydrolase	hydrolase	NN
cord-006229-7yoilsho	4558	14	(	(	-LRB-
cord-006229-7yoilsho	4558	15	FAAH	FAAH	NNP
cord-006229-7yoilsho	4558	16	)	)	-RRB-
cord-006229-7yoilsho	4558	17	,	,	,
cord-006229-7yoilsho	4558	18	which	which	WDT
cord-006229-7yoilsho	4558	19	catalyzes	catalyze	VBZ
cord-006229-7yoilsho	4558	20	the	the	DT
cord-006229-7yoilsho	4558	21	degradation	degradation	NN
cord-006229-7yoilsho	4558	22	of	of	IN
cord-006229-7yoilsho	4558	23	endocannabinoids	endocannabinoid	NNS
cord-006229-7yoilsho	4558	24	(	(	-LRB-
cord-006229-7yoilsho	4558	25	anandamide	anandamide	NN
cord-006229-7yoilsho	4558	26	,	,	,
cord-006229-7yoilsho	4558	27	2-arachidonoylglycerol	2-arachidonoylglycerol	CD
cord-006229-7yoilsho	4558	28	)	)	-RRB-
cord-006229-7yoilsho	4558	29	and	and	CC
cord-006229-7yoilsho	4558	30	endocannabinoid	endocannabinoid	NN
cord-006229-7yoilsho	4558	31	-	-	HYPH
cord-006229-7yoilsho	4558	32	like	like	JJ
cord-006229-7yoilsho	4558	33	substances	substance	NNS
cord-006229-7yoilsho	4558	34	(	(	-LRB-
cord-006229-7yoilsho	4558	35	N	n	CD
cord-006229-7yoilsho	4558	36	-	-	HYPH
cord-006229-7yoilsho	4558	37	oleoylethanolamine	oleoylethanolamine	NNP
cord-006229-7yoilsho	4558	38	,	,	,
cord-006229-7yoilsho	4558	39	N	N	NNP
cord-006229-7yoilsho	4558	40	-	-	HYPH
cord-006229-7yoilsho	4558	41	palmitoylethanolamine	palmitoylethanolamine	NNP
cord-006229-7yoilsho	4558	42	)	)	-RRB-
cord-006229-7yoilsho	4558	43	.	.	.
cord-006229-7yoilsho	4559	1	In	in	IN
cord-006229-7yoilsho	4559	2	Boyden	Boyden	NNP
cord-006229-7yoilsho	4559	3	chamber	chamber	NN
cord-006229-7yoilsho	4559	4	assays	assay	NNS
cord-006229-7yoilsho	4559	5	,	,	,
cord-006229-7yoilsho	4559	6	the	the	DT
cord-006229-7yoilsho	4559	7	FAAH	FAAH	NNP
cord-006229-7yoilsho	4559	8	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	4559	9	,	,	,
cord-006229-7yoilsho	4559	10	URB597	URB597	NNP
cord-006229-7yoilsho	4559	11	and	and	CC
cord-006229-7yoilsho	4559	12	arachidonoyl	arachidonoyl	JJ
cord-006229-7yoilsho	4559	13	serotonin	serotonin	NN
cord-006229-7yoilsho	4559	14	(	(	-LRB-
cord-006229-7yoilsho	4559	15	AA-5HT	AA-5HT	NNP
cord-006229-7yoilsho	4559	16	)	)	-RRB-
cord-006229-7yoilsho	4559	17	,	,	,
cord-006229-7yoilsho	4559	18	were	be	VBD
cord-006229-7yoilsho	4559	19	found	find	VBN
cord-006229-7yoilsho	4559	20	to	to	TO
cord-006229-7yoilsho	4559	21	increase	increase	VB
cord-006229-7yoilsho	4559	22	the	the	DT
cord-006229-7yoilsho	4559	23	migration	migration	NN
cord-006229-7yoilsho	4559	24	of	of	IN
cord-006229-7yoilsho	4559	25	human	human	JJ
cord-006229-7yoilsho	4559	26	adipose	adipose	NN
cord-006229-7yoilsho	4559	27	-	-	HYPH
cord-006229-7yoilsho	4559	28	derived	derive	VBN
cord-006229-7yoilsho	4559	29	MSCs	msc	NNS
cord-006229-7yoilsho	4559	30	.	.	.
cord-006229-7yoilsho	4560	1	LC	LC	NNP
cord-006229-7yoilsho	4560	2	-	-	HYPH
cord-006229-7yoilsho	4560	3	MS	MS	NNP
cord-006229-7yoilsho	4560	4	analyses	analysis	NNS
cord-006229-7yoilsho	4560	5	revealed	reveal	VBD
cord-006229-7yoilsho	4560	6	increased	increase	VBN
cord-006229-7yoilsho	4560	7	levels	level	NNS
cord-006229-7yoilsho	4560	8	of	of	IN
cord-006229-7yoilsho	4560	9	all	all	DT
cord-006229-7yoilsho	4560	10	four	four	CD
cord-006229-7yoilsho	4560	11	aforementioned	aforementioned	JJ
cord-006229-7yoilsho	4560	12	FAAH	FAAH	NNP
cord-006229-7yoilsho	4560	13	substrates	substrate	NNS
cord-006229-7yoilsho	4560	14	in	in	IN
cord-006229-7yoilsho	4560	15	MSCs	msc	NNS
cord-006229-7yoilsho	4560	16	incubated	incubate	VBN
cord-006229-7yoilsho	4560	17	with	with	IN
cord-006229-7yoilsho	4560	18	either	either	CC
cord-006229-7yoilsho	4560	19	FAAH	FAAH	NNP
cord-006229-7yoilsho	4560	20	inhibitor	inhibitor	NN
cord-006229-7yoilsho	4560	21	.	.	.
cord-006229-7yoilsho	4561	1	Following	follow	VBG
cord-006229-7yoilsho	4561	2	addition	addition	NN
cord-006229-7yoilsho	4561	3	to	to	IN
cord-006229-7yoilsho	4561	4	MSCs	msc	NNS
cord-006229-7yoilsho	4561	5	,	,	,
cord-006229-7yoilsho	4561	6	all	all	DT
cord-006229-7yoilsho	4561	7	FAAH	faah	NN
cord-006229-7yoilsho	4561	8	substrates	substrate	NNS
cord-006229-7yoilsho	4561	9	mimicked	mimic	VBD
cord-006229-7yoilsho	4561	10	the	the	DT
cord-006229-7yoilsho	4561	11	promigratory	promigratory	JJ
cord-006229-7yoilsho	4561	12	action	action	NN
cord-006229-7yoilsho	4561	13	of	of	IN
cord-006229-7yoilsho	4561	14	FAAH	FAAH	NNP
cord-006229-7yoilsho	4561	15	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	4561	16	.	.	.
cord-006229-7yoilsho	4562	1	Promigratory	promigratory	JJ
cord-006229-7yoilsho	4562	2	effects	effect	NNS
cord-006229-7yoilsho	4562	3	of	of	IN
cord-006229-7yoilsho	4562	4	FAAH	FAAH	NNP
cord-006229-7yoilsho	4562	5	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	4562	6	and	and	CC
cord-006229-7yoilsho	4562	7	substrates	substrate	NNS
cord-006229-7yoilsho	4562	8	were	be	VBD
cord-006229-7yoilsho	4562	9	causally	causally	RB
cord-006229-7yoilsho	4562	10	linked	link	VBN
cord-006229-7yoilsho	4562	11	to	to	IN
cord-006229-7yoilsho	4562	12	activation	activation	NN
cord-006229-7yoilsho	4562	13	of	of	IN
cord-006229-7yoilsho	4562	14	p42/44	p42/44	NNP
cord-006229-7yoilsho	4562	15	mitogen	mitogen	NN
cord-006229-7yoilsho	4562	16	-	-	HYPH
cord-006229-7yoilsho	4562	17	activated	activate	VBN
cord-006229-7yoilsho	4562	18	protein	protein	NN
cord-006229-7yoilsho	4562	19	kinase	kinase	NN
cord-006229-7yoilsho	4562	20	(	(	-LRB-
cord-006229-7yoilsho	4562	21	MAPK	MAPK	NNP
cord-006229-7yoilsho	4562	22	)	)	-RRB-
cord-006229-7yoilsho	4562	23	,	,	,
cord-006229-7yoilsho	4562	24	as	as	RB
cord-006229-7yoilsho	4562	25	well	well	RB
cord-006229-7yoilsho	4562	26	as	as	IN
cord-006229-7yoilsho	4562	27	to	to	IN
cord-006229-7yoilsho	4562	28	cytosol	cytosol	NN
cord-006229-7yoilsho	4562	29	-	-	HYPH
cord-006229-7yoilsho	4562	30	to	to	IN
cord-006229-7yoilsho	4562	31	-	-	HYPH
cord-006229-7yoilsho	4562	32	nucleus	nucleus	NN
cord-006229-7yoilsho	4562	33	translocation	translocation	NN
cord-006229-7yoilsho	4562	34	of	of	IN
cord-006229-7yoilsho	4562	35	the	the	DT
cord-006229-7yoilsho	4562	36	transcription	transcription	NN
cord-006229-7yoilsho	4562	37	factor	factor	NN
cord-006229-7yoilsho	4562	38	,	,	,
cord-006229-7yoilsho	4562	39	peroxisome	peroxisome	NN
cord-006229-7yoilsho	4562	40	proliferator	proliferator	NN
cord-006229-7yoilsho	4562	41	-	-	HYPH
cord-006229-7yoilsho	4562	42	activated	activate	VBN
cord-006229-7yoilsho	4562	43	receptor	receptor	NN
cord-006229-7yoilsho	4562	44	α	α	NNP
cord-006229-7yoilsho	4562	45	(	(	-LRB-
cord-006229-7yoilsho	4562	46	PPARα	PPARα	NNP
cord-006229-7yoilsho	4562	47	)	)	-RRB-
cord-006229-7yoilsho	4562	48	.	.	.
cord-006229-7yoilsho	4563	1	Whereas	whereas	IN
cord-006229-7yoilsho	4563	2	PPARα	PPARα	NNS
cord-006229-7yoilsho	4563	3	activation	activation	NN
cord-006229-7yoilsho	4563	4	by	by	IN
cord-006229-7yoilsho	4563	5	FAAH	FAAH	NNP
cord-006229-7yoilsho	4563	6	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	4563	7	and	and	CC
cord-006229-7yoilsho	4563	8	substrates	substrate	NNS
cord-006229-7yoilsho	4563	9	became	become	VBD
cord-006229-7yoilsho	4563	10	reversed	reverse	VBN
cord-006229-7yoilsho	4563	11	upon	upon	IN
cord-006229-7yoilsho	4563	12	inhibition	inhibition	NN
cord-006229-7yoilsho	4563	13	of	of	IN
cord-006229-7yoilsho	4563	14	p42/44	p42/44	NNP
cord-006229-7yoilsho	4563	15	MAPK	MAPK	NNP
cord-006229-7yoilsho	4563	16	activation	activation	NN
cord-006229-7yoilsho	4563	17	,	,	,
cord-006229-7yoilsho	4563	18	a	a	DT
cord-006229-7yoilsho	4563	19	blockade	blockade	NN
cord-006229-7yoilsho	4563	20	of	of	IN
cord-006229-7yoilsho	4563	21	PPARα	PPARα	NNS
cord-006229-7yoilsho	4563	22	left	leave	VBD
cord-006229-7yoilsho	4563	23	p42/44	p42/44	NNP
cord-006229-7yoilsho	4563	24	MAPK	MAPK	NNP
cord-006229-7yoilsho	4563	25	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	4563	26	unaltered	unaltered	JJ
cord-006229-7yoilsho	4563	27	.	.	.
cord-006229-7yoilsho	4564	1	Collectively	collectively	RB
cord-006229-7yoilsho	4564	2	,	,	,
cord-006229-7yoilsho	4564	3	these	these	DT
cord-006229-7yoilsho	4564	4	data	datum	NNS
cord-006229-7yoilsho	4564	5	demonstrate	demonstrate	VBP
cord-006229-7yoilsho	4564	6	FAAH	FAAH	NNP
cord-006229-7yoilsho	4564	7	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	4564	8	and	and	CC
cord-006229-7yoilsho	4564	9	substrates	substrate	NNS
cord-006229-7yoilsho	4564	10	to	to	TO
cord-006229-7yoilsho	4564	11	cause	cause	VB
cord-006229-7yoilsho	4564	12	p42/44	p42/44	NNP
cord-006229-7yoilsho	4564	13	MAPK	MAPK	NNP
cord-006229-7yoilsho	4564	14	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	4564	15	,	,	,
cord-006229-7yoilsho	4564	16	which	which	WDT
cord-006229-7yoilsho	4564	17	subsequently	subsequently	RB
cord-006229-7yoilsho	4564	18	activates	activate	VBZ
cord-006229-7yoilsho	4564	19	PPARα	PPARα	NNS
cord-006229-7yoilsho	4564	20	to	to	TO
cord-006229-7yoilsho	4564	21	confer	confer	VB
cord-006229-7yoilsho	4564	22	increased	increased	JJ
cord-006229-7yoilsho	4564	23	migration	migration	NN
cord-006229-7yoilsho	4564	24	of	of	IN
cord-006229-7yoilsho	4564	25	MSCs	msc	NNS
cord-006229-7yoilsho	4564	26	.	.	.
cord-006229-7yoilsho	4565	1	This	this	DT
cord-006229-7yoilsho	4565	2	novel	novel	JJ
cord-006229-7yoilsho	4565	3	pathway	pathway	NN
cord-006229-7yoilsho	4565	4	may	may	MD
cord-006229-7yoilsho	4565	5	be	be	VB
cord-006229-7yoilsho	4565	6	involved	involve	VBN
cord-006229-7yoilsho	4565	7	in	in	IN
cord-006229-7yoilsho	4565	8	regenerative	regenerative	JJ
cord-006229-7yoilsho	4565	9	effects	effect	NNS
cord-006229-7yoilsho	4565	10	of	of	IN
cord-006229-7yoilsho	4565	11	endocannabinoids	endocannabinoid	NNS
cord-006229-7yoilsho	4565	12	whose	whose	WP$
cord-006229-7yoilsho	4565	13	degradation	degradation	NN
cord-006229-7yoilsho	4565	14	could	could	MD
cord-006229-7yoilsho	4565	15	be	be	VB
cord-006229-7yoilsho	4565	16	a	a	DT
cord-006229-7yoilsho	4565	17	target	target	NN
cord-006229-7yoilsho	4565	18	of	of	IN
cord-006229-7yoilsho	4565	19	pharmacological	pharmacological	JJ
cord-006229-7yoilsho	4565	20	intervention	intervention	NN
cord-006229-7yoilsho	4565	21	by	by	IN
cord-006229-7yoilsho	4565	22	FAAH	FAAH	NNP
cord-006229-7yoilsho	4565	23	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	4565	24	.	.	.
cord-006229-7yoilsho	4566	1	Background	background	NN
cord-006229-7yoilsho	4566	2	:	:	:
cord-006229-7yoilsho	4567	1	The	the	DT
cord-006229-7yoilsho	4567	2	hematopoietic	hematopoietic	JJ
cord-006229-7yoilsho	4567	3	disorder	disorder	NN
cord-006229-7yoilsho	4567	4	chronic	chronic	JJ
cord-006229-7yoilsho	4567	5	myeloid	myeloid	NN
cord-006229-7yoilsho	4567	6	leukemia	leukemia	NN
cord-006229-7yoilsho	4567	7	(	(	-LRB-
cord-006229-7yoilsho	4567	8	CML	CML	NNP
cord-006229-7yoilsho	4567	9	)	)	-RRB-
cord-006229-7yoilsho	4567	10	is	be	VBZ
cord-006229-7yoilsho	4567	11	one	one	CD
cord-006229-7yoilsho	4567	12	of	of	IN
cord-006229-7yoilsho	4567	13	the	the	DT
cord-006229-7yoilsho	4567	14	most	most	RBS
cord-006229-7yoilsho	4567	15	extensively	extensively	RB
cord-006229-7yoilsho	4567	16	studied	study	VBN
cord-006229-7yoilsho	4567	17	neoplasms	neoplasm	NNS
cord-006229-7yoilsho	4567	18	.	.	.
cord-006229-7yoilsho	4568	1	It	-PRON-	PRP
cord-006229-7yoilsho	4568	2	is	be	VBZ
cord-006229-7yoilsho	4568	3	caused	cause	VBN
cord-006229-7yoilsho	4568	4	by	by	IN
cord-006229-7yoilsho	4568	5	translocation	translocation	NN
cord-006229-7yoilsho	4568	6	between	between	IN
cord-006229-7yoilsho	4568	7	chromosomes	chromosome	NNS
cord-006229-7yoilsho	4568	8	9	9	CD
cord-006229-7yoilsho	4568	9	and	and	CC
cord-006229-7yoilsho	4568	10	22	22	CD
cord-006229-7yoilsho	4568	11	leading	lead	VBG
cord-006229-7yoilsho	4568	12	to	to	IN
cord-006229-7yoilsho	4568	13	the	the	DT
cord-006229-7yoilsho	4568	14	formation	formation	NN
cord-006229-7yoilsho	4568	15	of	of	IN
cord-006229-7yoilsho	4568	16	the	the	DT
cord-006229-7yoilsho	4568	17	Philadelphia	Philadelphia	NNP
cord-006229-7yoilsho	4568	18	chromosome	chromosome	NN
cord-006229-7yoilsho	4568	19	and	and	CC
cord-006229-7yoilsho	4568	20	the	the	DT
cord-006229-7yoilsho	4568	21	BCR	BCR	NNP
cord-006229-7yoilsho	4568	22	-	-	HYPH
cord-006229-7yoilsho	4568	23	ABL	ABL	NNP
cord-006229-7yoilsho	4568	24	fusiongene	fusiongene	NN
cord-006229-7yoilsho	4568	25	.	.	.
cord-006229-7yoilsho	4569	1	First	first	JJ
cord-006229-7yoilsho	4569	2	-	-	HYPH
cord-006229-7yoilsho	4569	3	line	line	NN
cord-006229-7yoilsho	4569	4	targeted	target	VBN
cord-006229-7yoilsho	4569	5	therapy	therapy	NN
cord-006229-7yoilsho	4569	6	is	be	VBZ
cord-006229-7yoilsho	4569	7	still	still	RB
cord-006229-7yoilsho	4569	8	the	the	DT
cord-006229-7yoilsho	4569	9	tyrosine	tyrosine	NN
cord-006229-7yoilsho	4569	10	-	-	HYPH
cord-006229-7yoilsho	4569	11	kinase	kinase	NN
cord-006229-7yoilsho	4569	12	inhibitor	inhibitor	NN
cord-006229-7yoilsho	4569	13	imatinib	imatinib	RB
cord-006229-7yoilsho	4569	14	(	(	-LRB-
cord-006229-7yoilsho	4569	15	IM	IM	NNP
cord-006229-7yoilsho	4569	16	)	)	-RRB-
cord-006229-7yoilsho	4569	17	,	,	,
cord-006229-7yoilsho	4569	18	which	which	WDT
cord-006229-7yoilsho	4569	19	led	lead	VBD
cord-006229-7yoilsho	4569	20	to	to	IN
cord-006229-7yoilsho	4569	21	tremendous	tremendous	JJ
cord-006229-7yoilsho	4569	22	success	success	NN
cord-006229-7yoilsho	4569	23	in	in	IN
cord-006229-7yoilsho	4569	24	treatment	treatment	NN
cord-006229-7yoilsho	4569	25	.	.	.
cord-006229-7yoilsho	4570	1	However	however	RB
cord-006229-7yoilsho	4570	2	,	,	,
cord-006229-7yoilsho	4570	3	the	the	DT
cord-006229-7yoilsho	4570	4	amount	amount	NN
cord-006229-7yoilsho	4570	5	of	of	IN
cord-006229-7yoilsho	4570	6	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	4570	7	resistances	resistance	NNS
cord-006229-7yoilsho	4570	8	is	be	VBZ
cord-006229-7yoilsho	4570	9	increasing	increase	VBG
cord-006229-7yoilsho	4570	10	,	,	,
cord-006229-7yoilsho	4570	11	caused	cause	VBN
cord-006229-7yoilsho	4570	12	either	either	CC
cord-006229-7yoilsho	4570	13	by	by	IN
cord-006229-7yoilsho	4570	14	BCR	BCR	NNP
cord-006229-7yoilsho	4570	15	-	-	HYPH
cord-006229-7yoilsho	4570	16	ABL	ABL	NNP
cord-006229-7yoilsho	4570	17	-	-	HYPH
cord-006229-7yoilsho	4570	18	dependent	dependent	JJ
cord-006229-7yoilsho	4570	19	mechanisms	mechanism	NNS
cord-006229-7yoilsho	4570	20	(	(	-LRB-
cord-006229-7yoilsho	4570	21	e.g.	e.g.	IN
cord-006229-7yoilsho	4570	22	BCR	BCR	NNP
cord-006229-7yoilsho	4570	23	-	-	HYPH
cord-006229-7yoilsho	4570	24	ABL	ABL	NNP
cord-006229-7yoilsho	4570	25	amplification	amplification	NN
cord-006229-7yoilsho	4570	26	/	/	SYM
cord-006229-7yoilsho	4570	27	overexpression	overexpression	NN
cord-006229-7yoilsho	4570	28	,	,	,
cord-006229-7yoilsho	4570	29	point	point	NN
cord-006229-7yoilsho	4570	30	mutations	mutation	NNS
cord-006229-7yoilsho	4570	31	)	)	-RRB-
cord-006229-7yoilsho	4570	32	or	or	CC
cord-006229-7yoilsho	4570	33	BCR	BCR	NNP
cord-006229-7yoilsho	4570	34	-	-	HYPH
cord-006229-7yoilsho	4570	35	ABLindependent	ABLindependent	NNP
cord-006229-7yoilsho	4570	36	mechanisms	mechanism	NNS
cord-006229-7yoilsho	4570	37	.	.	.
cord-006229-7yoilsho	4571	1	These	these	DT
cord-006229-7yoilsho	4571	2	might	may	MD
cord-006229-7yoilsho	4571	3	be	be	VB
cord-006229-7yoilsho	4571	4	linked	link	VBN
cord-006229-7yoilsho	4571	5	to	to	IN
cord-006229-7yoilsho	4571	6	alterations	alteration	NNS
cord-006229-7yoilsho	4571	7	in	in	IN
cord-006229-7yoilsho	4571	8	drug	drug	NN
cord-006229-7yoilsho	4571	9	transporter	transporter	NN
cord-006229-7yoilsho	4571	10	expression	expression	NN
cord-006229-7yoilsho	4571	11	or	or	CC
cord-006229-7yoilsho	4571	12	particularly	particularly	RB
cord-006229-7yoilsho	4571	13	,	,	,
cord-006229-7yoilsho	4571	14	microRNA	microrna	NN
cord-006229-7yoilsho	4571	15	-	-	HYPH
cord-006229-7yoilsho	4571	16	expression	expression	NN
cord-006229-7yoilsho	4571	17	levels	level	NNS
cord-006229-7yoilsho	4571	18	.	.	.
cord-006229-7yoilsho	4572	1	In	in	IN
cord-006229-7yoilsho	4572	2	our	-PRON-	PRP$
cord-006229-7yoilsho	4572	3	previous	previous	JJ
cord-006229-7yoilsho	4572	4	study	study	NN
cord-006229-7yoilsho	4572	5	,	,	,
cord-006229-7yoilsho	4572	6	we	-PRON-	PRP
cord-006229-7yoilsho	4572	7	analyzed	analyze	VBD
cord-006229-7yoilsho	4572	8	the	the	DT
cord-006229-7yoilsho	4572	9	changes	change	NNS
cord-006229-7yoilsho	4572	10	of	of	IN
cord-006229-7yoilsho	4572	11	microRNA	microRNA	NNP
cord-006229-7yoilsho	4572	12	expression	expression	NN
cord-006229-7yoilsho	4572	13	profiles	profile	NNS
cord-006229-7yoilsho	4572	14	during	during	IN
cord-006229-7yoilsho	4572	15	the	the	DT
cord-006229-7yoilsho	4572	16	development	development	NN
cord-006229-7yoilsho	4572	17	of	of	IN
cord-006229-7yoilsho	4572	18	IMresistances	IMresistances	NNP
cord-006229-7yoilsho	4572	19	in	in	IN
cord-006229-7yoilsho	4572	20	the	the	DT
cord-006229-7yoilsho	4572	21	leukemic	leukemic	JJ
cord-006229-7yoilsho	4572	22	cell	cell	NN
cord-006229-7yoilsho	4572	23	line	line	NN
cord-006229-7yoilsho	4572	24	K562	k562	CD
cord-006229-7yoilsho	4572	25	.	.	.
cord-006229-7yoilsho	4573	1	An	an	DT
cord-006229-7yoilsho	4573	2	inverse	inverse	JJ
cord-006229-7yoilsho	4573	3	correlation	correlation	NN
cord-006229-7yoilsho	4573	4	of	of	IN
cord-006229-7yoilsho	4573	5	miR-212	mir-212	JJ
cord-006229-7yoilsho	4573	6	expression	expression	NN
cord-006229-7yoilsho	4573	7	and	and	CC
cord-006229-7yoilsho	4573	8	protein	protein	NN
cord-006229-7yoilsho	4573	9	levels	level	NNS
cord-006229-7yoilsho	4573	10	of	of	IN
cord-006229-7yoilsho	4573	11	the	the	DT
cord-006229-7yoilsho	4573	12	efflux	efflux	NN
cord-006229-7yoilsho	4573	13	transporter	transporter	NN
cord-006229-7yoilsho	4573	14	ATP	ATP	NNP
cord-006229-7yoilsho	4573	15	-	-	HYPH
cord-006229-7yoilsho	4573	16	binding	bind	VBG
cord-006229-7yoilsho	4573	17	cassette	cassette	NN
cord-006229-7yoilsho	4573	18	transporter	transporter	NN
cord-006229-7yoilsho	4573	19	G2	G2	NNP
cord-006229-7yoilsho	4573	20	(	(	-LRB-
cord-006229-7yoilsho	4573	21	ABCG2	abcg2	NN
cord-006229-7yoilsho	4573	22	)	)	-RRB-
cord-006229-7yoilsho	4573	23	was	be	VBD
cord-006229-7yoilsho	4573	24	observed	observe	VBN
cord-006229-7yoilsho	4573	25	in	in	IN
cord-006229-7yoilsho	4573	26	cells	cell	NNS
cord-006229-7yoilsho	4573	27	resistant	resistant	JJ
cord-006229-7yoilsho	4573	28	to	to	IN
cord-006229-7yoilsho	4573	29	different	different	JJ
cord-006229-7yoilsho	4573	30	IM	im	NN
cord-006229-7yoilsho	4573	31	-	-	HYPH
cord-006229-7yoilsho	4573	32	concentrations	concentration	NNS
cord-006229-7yoilsho	4573	33	,	,	,
cord-006229-7yoilsho	4573	34	pointing	point	VBG
cord-006229-7yoilsho	4573	35	to	to	IN
cord-006229-7yoilsho	4573	36	a	a	DT
cord-006229-7yoilsho	4573	37	relation	relation	NN
cord-006229-7yoilsho	4573	38	of	of	IN
cord-006229-7yoilsho	4573	39	miR-212	mir-212	NN
cord-006229-7yoilsho	4573	40	to	to	IN
cord-006229-7yoilsho	4573	41	IM	im	NN
cord-006229-7yoilsho	4573	42	-	-	HYPH
cord-006229-7yoilsho	4573	43	resistance	resistance	NN
cord-006229-7yoilsho	4573	44	.	.	.
cord-006229-7yoilsho	4574	1	Hence	hence	RB
cord-006229-7yoilsho	4574	2	,	,	,
cord-006229-7yoilsho	4574	3	we	-PRON-	PRP
cord-006229-7yoilsho	4574	4	investigate	investigate	VBP
cord-006229-7yoilsho	4574	5	in	in	IN
cord-006229-7yoilsho	4574	6	current	current	JJ
cord-006229-7yoilsho	4574	7	studies	study	NNS
cord-006229-7yoilsho	4574	8	,	,	,
cord-006229-7yoilsho	4574	9	how	how	WRB
cord-006229-7yoilsho	4574	10	the	the	DT
cord-006229-7yoilsho	4574	11	influence	influence	NN
cord-006229-7yoilsho	4574	12	of	of	IN
cord-006229-7yoilsho	4574	13	miR-212	mir-212	NN
cord-006229-7yoilsho	4574	14	on	on	IN
cord-006229-7yoilsho	4574	15	IM	im	NN
cord-006229-7yoilsho	4574	16	-	-	HYPH
cord-006229-7yoilsho	4574	17	sensitivity	sensitivity	NN
cord-006229-7yoilsho	4574	18	could	could	MD
cord-006229-7yoilsho	4574	19	be	be	VB
cord-006229-7yoilsho	4574	20	explained	explain	VBN
cord-006229-7yoilsho	4574	21	.	.	.
cord-006229-7yoilsho	4575	1	Methods	method	NNS
cord-006229-7yoilsho	4575	2	:	:	:
cord-006229-7yoilsho	4575	3	We	-PRON-	PRP
cord-006229-7yoilsho	4575	4	transfected	transfecte	VBD
cord-006229-7yoilsho	4575	5	K562	k562	CD
cord-006229-7yoilsho	4575	6	cells	cell	NNS
cord-006229-7yoilsho	4575	7	,	,	,
cord-006229-7yoilsho	4575	8	sensitive	sensitive	JJ
cord-006229-7yoilsho	4575	9	treatment	treatment	NN
cord-006229-7yoilsho	4575	10	-	-	HYPH
cord-006229-7yoilsho	4575	11	naïve	naïve	JJ
cord-006229-7yoilsho	4575	12	cells	cell	NNS
cord-006229-7yoilsho	4575	13	and	and	CC
cord-006229-7yoilsho	4575	14	cells	cell	NNS
cord-006229-7yoilsho	4575	15	resistant	resistant	JJ
cord-006229-7yoilsho	4575	16	to	to	IN
cord-006229-7yoilsho	4575	17	various	various	JJ
cord-006229-7yoilsho	4575	18	IM	im	NN
cord-006229-7yoilsho	4575	19	-	-	HYPH
cord-006229-7yoilsho	4575	20	concentrations	concentration	NNS
cord-006229-7yoilsho	4575	21	,	,	,
cord-006229-7yoilsho	4575	22	either	either	CC
cord-006229-7yoilsho	4575	23	with	with	IN
cord-006229-7yoilsho	4575	24	miR	mir	NN
cord-006229-7yoilsho	4575	25	-	-	HYPH
cord-006229-7yoilsho	4575	26	mimic	mimic	JJ
cord-006229-7yoilsho	4575	27	pre	pre	JJ
cord-006229-7yoilsho	4575	28	-	-	JJ
cord-006229-7yoilsho	4575	29	miR-212	mir-212	JJ
cord-006229-7yoilsho	4575	30	or	or	CC
cord-006229-7yoilsho	4575	31	inhibitory	inhibitory	JJ
cord-006229-7yoilsho	4575	32	anti	anti	JJ
cord-006229-7yoilsho	4575	33	-	-	JJ
cord-006229-7yoilsho	4575	34	miR-212	mir-212	JJ
cord-006229-7yoilsho	4575	35	,	,	,
cord-006229-7yoilsho	4575	36	challenged	challenge	VBD
cord-006229-7yoilsho	4575	37	them	-PRON-	PRP
cord-006229-7yoilsho	4575	38	with	with	IN
cord-006229-7yoilsho	4575	39	IM	IM	NNP
cord-006229-7yoilsho	4575	40	and	and	CC
cord-006229-7yoilsho	4575	41	analyzed	analyze	VBD
cord-006229-7yoilsho	4575	42	effects	effect	NNS
cord-006229-7yoilsho	4575	43	on	on	IN
cord-006229-7yoilsho	4575	44	cell	cell	NN
cord-006229-7yoilsho	4575	45	viability	viability	NN
cord-006229-7yoilsho	4575	46	,	,	,
cord-006229-7yoilsho	4575	47	activation	activation	NN
cord-006229-7yoilsho	4575	48	of	of	IN
cord-006229-7yoilsho	4575	49	apoptosis	apoptosis	NN
cord-006229-7yoilsho	4575	50	and	and	CC
cord-006229-7yoilsho	4575	51	cell	cell	NN
cord-006229-7yoilsho	4575	52	death	death	NN
cord-006229-7yoilsho	4575	53	using	use	VBG
cord-006229-7yoilsho	4575	54	WST-1-	WST-1-	NNP
cord-006229-7yoilsho	4575	55	,	,	,
cord-006229-7yoilsho	4575	56	Caspase	Caspase	NNP
cord-006229-7yoilsho	4575	57	Glo	Glo	NNP
cord-006229-7yoilsho	4575	58	9-assay	9-assay	CD
cord-006229-7yoilsho	4575	59	and	and	CC
cord-006229-7yoilsho	4575	60	cell	cell	NN
cord-006229-7yoilsho	4575	61	counting	counting	NN
cord-006229-7yoilsho	4575	62	.	.	.
cord-006229-7yoilsho	4576	1	In	in	IN
cord-006229-7yoilsho	4576	2	addition	addition	NN
cord-006229-7yoilsho	4576	3	,	,	,
cord-006229-7yoilsho	4576	4	we	-PRON-	PRP
cord-006229-7yoilsho	4576	5	analyzed	analyze	VBD
cord-006229-7yoilsho	4576	6	changes	change	NNS
cord-006229-7yoilsho	4576	7	in	in	IN
cord-006229-7yoilsho	4576	8	ABCG2	abcg2	NN
cord-006229-7yoilsho	4576	9	expression	expression	NN
cord-006229-7yoilsho	4576	10	using	use	VBG
cord-006229-7yoilsho	4576	11	flow	flow	NN
cord-006229-7yoilsho	4576	12	cytometry	cytometry	NN
cord-006229-7yoilsho	4576	13	and	and	CC
cord-006229-7yoilsho	4576	14	qRT	qRT	NNP
cord-006229-7yoilsho	4576	15	-	-	HYPH
cord-006229-7yoilsho	4576	16	PCR	PCR	NNP
cord-006229-7yoilsho	4576	17	and	and	CC
cord-006229-7yoilsho	4576	18	investigated	investigate	VBD
cord-006229-7yoilsho	4576	19	alterations	alteration	NNS
cord-006229-7yoilsho	4576	20	in	in	IN
cord-006229-7yoilsho	4576	21	IM	im	NN
cord-006229-7yoilsho	4576	22	-	-	:
cord-006229-7yoilsho	4576	23	efflux	efflux	NN
cord-006229-7yoilsho	4576	24	using	use	VBG
cord-006229-7yoilsho	4576	25	HPLC	HPLC	NNP
cord-006229-7yoilsho	4576	26	and	and	CC
cord-006229-7yoilsho	4576	27	Hoechst	Hoechst	NNP
cord-006229-7yoilsho	4576	28	efflux	efflux	NN
cord-006229-7yoilsho	4576	29	assay	assay	NN
cord-006229-7yoilsho	4576	30	.	.	.
cord-006229-7yoilsho	4577	1	Results	result	NNS
cord-006229-7yoilsho	4577	2	:	:	:
cord-006229-7yoilsho	4578	1	Under	under	IN
cord-006229-7yoilsho	4578	2	IM	im	NN
cord-006229-7yoilsho	4578	3	-	-	HYPH
cord-006229-7yoilsho	4578	4	treatment	treatment	NN
cord-006229-7yoilsho	4578	5	,	,	,
cord-006229-7yoilsho	4578	6	sensitive	sensitive	JJ
cord-006229-7yoilsho	4578	7	K562	k562	XX
cord-006229-7yoilsho	4578	8	showed	show	VBD
cord-006229-7yoilsho	4578	9	an	an	DT
cord-006229-7yoilsho	4578	10	effect	effect	NN
cord-006229-7yoilsho	4578	11	of	of	IN
cord-006229-7yoilsho	4578	12	miR-212-inhibition	miR-212-inhibition	NNP
cord-006229-7yoilsho	4578	13	using	use	VBG
cord-006229-7yoilsho	4578	14	anti	anti	JJ
cord-006229-7yoilsho	4578	15	-	-	JJ
cord-006229-7yoilsho	4578	16	miR-212	mir-212	JJ
cord-006229-7yoilsho	4578	17	.	.	.
cord-006229-7yoilsho	4579	1	This	this	DT
cord-006229-7yoilsho	4579	2	led	lead	VBD
cord-006229-7yoilsho	4579	3	to	to	IN
cord-006229-7yoilsho	4579	4	a	a	DT
cord-006229-7yoilsho	4579	5	significant	significant	JJ
cord-006229-7yoilsho	4579	6	promotion	promotion	NN
cord-006229-7yoilsho	4579	7	of	of	IN
cord-006229-7yoilsho	4579	8	cell	cell	NN
cord-006229-7yoilsho	4579	9	survival	survival	NN
cord-006229-7yoilsho	4579	10	apparent	apparent	JJ
cord-006229-7yoilsho	4579	11	on	on	IN
cord-006229-7yoilsho	4579	12	the	the	DT
cord-006229-7yoilsho	4579	13	level	level	NN
cord-006229-7yoilsho	4579	14	of	of	IN
cord-006229-7yoilsho	4579	15	respiratory	respiratory	JJ
cord-006229-7yoilsho	4579	16	chain	chain	NN
cord-006229-7yoilsho	4579	17	function	function	NN
cord-006229-7yoilsho	4579	18	(	(	-LRB-
cord-006229-7yoilsho	4579	19	p<0.01	p<0.01	NNP
cord-006229-7yoilsho	4579	20	)	)	-RRB-
cord-006229-7yoilsho	4579	21	and	and	CC
cord-006229-7yoilsho	4579	22	cell	cell	NN
cord-006229-7yoilsho	4579	23	membrane	membrane	NN
cord-006229-7yoilsho	4579	24	integrity	integrity	NN
cord-006229-7yoilsho	4579	25	and	and	CC
cord-006229-7yoilsho	4579	26	reduced	reduce	VBN
cord-006229-7yoilsho	4579	27	capase-9	capase-9	NN
cord-006229-7yoilsho	4579	28	activity	activity	NN
cord-006229-7yoilsho	4579	29	(	(	-LRB-
cord-006229-7yoilsho	4579	30	p<0.05	p<0.05	CD
cord-006229-7yoilsho	4579	31	)	)	-RRB-
cord-006229-7yoilsho	4579	32	.	.	.
cord-006229-7yoilsho	4580	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	4580	2	,	,	,
cord-006229-7yoilsho	4580	3	these	these	DT
cord-006229-7yoilsho	4580	4	miRNA	miRNA	NNP
cord-006229-7yoilsho	4580	5	-	-	HYPH
cord-006229-7yoilsho	4580	6	effects	effect	NNS
cord-006229-7yoilsho	4580	7	are	be	VBP
cord-006229-7yoilsho	4580	8	dose	dose	NN
cord-006229-7yoilsho	4580	9	-	-	HYPH
cord-006229-7yoilsho	4580	10	dependent	dependent	JJ
cord-006229-7yoilsho	4580	11	as	as	IN
cord-006229-7yoilsho	4580	12	confirmed	confirm	VBN
cord-006229-7yoilsho	4580	13	in	in	IN
cord-006229-7yoilsho	4580	14	concentration	concentration	NN
cord-006229-7yoilsho	4580	15	row	row	NN
cord-006229-7yoilsho	4580	16	-	-	HYPH
cord-006229-7yoilsho	4580	17	experiments	experiment	NNS
cord-006229-7yoilsho	4580	18	.	.	.
cord-006229-7yoilsho	4581	1	Regarding	regard	VBG
cord-006229-7yoilsho	4581	2	transport	transport	NN
cord-006229-7yoilsho	4581	3	and	and	CC
cord-006229-7yoilsho	4581	4	ABCG2	abcg2	NN
cord-006229-7yoilsho	4581	5	expression	expression	NN
cord-006229-7yoilsho	4581	6	,	,	,
cord-006229-7yoilsho	4581	7	we	-PRON-	PRP
cord-006229-7yoilsho	4581	8	found	find	VBD
cord-006229-7yoilsho	4581	9	that	that	IN
cord-006229-7yoilsho	4581	10	2	2	CD
cord-006229-7yoilsho	4581	11	µM	µm	NN
cord-006229-7yoilsho	4581	12	IM	im	JJ
cord-006229-7yoilsho	4581	13	-	-	HYPH
cord-006229-7yoilsho	4581	14	resistant	resistant	JJ
cord-006229-7yoilsho	4581	15	K562	k562	XX
cord-006229-7yoilsho	4581	16	do	do	VBP
cord-006229-7yoilsho	4581	17	not	not	RB
cord-006229-7yoilsho	4581	18	express	express	VB
cord-006229-7yoilsho	4581	19	higher	high	JJR
cord-006229-7yoilsho	4581	20	amounts	amount	NNS
cord-006229-7yoilsho	4581	21	of	of	IN
cord-006229-7yoilsho	4581	22	ABCG2	ABCG2	NNS
cord-006229-7yoilsho	4581	23	,	,	,
cord-006229-7yoilsho	4581	24	but	but	CC
cord-006229-7yoilsho	4581	25	showed	show	VBD
cord-006229-7yoilsho	4581	26	higher	high	JJR
cord-006229-7yoilsho	4581	27	transport	transport	NN
cord-006229-7yoilsho	4581	28	rates	rate	NNS
cord-006229-7yoilsho	4581	29	of	of	IN
cord-006229-7yoilsho	4581	30	IM	IM	NNP
cord-006229-7yoilsho	4581	31	or	or	CC
cord-006229-7yoilsho	4581	32	the	the	DT
cord-006229-7yoilsho	4581	33	ABCG2-substrate	ABCG2-substrate	NNP
cord-006229-7yoilsho	4581	34	Hoechst	Hoechst	NNP
cord-006229-7yoilsho	4581	35	33342	33342	CD
cord-006229-7yoilsho	4581	36	.	.	.
cord-006229-7yoilsho	4582	1	Conclusions	conclusion	NNS
cord-006229-7yoilsho	4582	2	:	:	:
cord-006229-7yoilsho	4583	1	Overall	overall	RB
cord-006229-7yoilsho	4583	2	,	,	,
cord-006229-7yoilsho	4583	3	these	these	DT
cord-006229-7yoilsho	4583	4	experiments	experiment	NNS
cord-006229-7yoilsho	4583	5	indicate	indicate	VBP
cord-006229-7yoilsho	4583	6	that	that	IN
cord-006229-7yoilsho	4583	7	miR-212	mir-212	NN
cord-006229-7yoilsho	4583	8	does	do	VBZ
cord-006229-7yoilsho	4583	9	not	not	RB
cord-006229-7yoilsho	4583	10	only	only	RB
cord-006229-7yoilsho	4583	11	affect	affect	VB
cord-006229-7yoilsho	4583	12	ABCG2-expression	abcg2-expression	CD
cord-006229-7yoilsho	4583	13	,	,	,
cord-006229-7yoilsho	4583	14	but	but	CC
cord-006229-7yoilsho	4583	15	also	also	RB
cord-006229-7yoilsho	4583	16	influences	influence	VBZ
cord-006229-7yoilsho	4583	17	cell	cell	NN
cord-006229-7yoilsho	4583	18	sensitivity	sensitivity	NN
cord-006229-7yoilsho	4583	19	to	to	IN
cord-006229-7yoilsho	4583	20	IM	IM	NNP
cord-006229-7yoilsho	4583	21	in	in	IN
cord-006229-7yoilsho	4583	22	a	a	DT
cord-006229-7yoilsho	4583	23	more	more	RBR
cord-006229-7yoilsho	4583	24	direct	direct	JJ
cord-006229-7yoilsho	4583	25	manner	manner	NN
cord-006229-7yoilsho	4583	26	.	.	.
cord-006229-7yoilsho	4584	1	Further	further	JJ
cord-006229-7yoilsho	4584	2	analysis	analysis	NN
cord-006229-7yoilsho	4584	3	will	will	MD
cord-006229-7yoilsho	4584	4	now	now	RB
cord-006229-7yoilsho	4584	5	be	be	VB
cord-006229-7yoilsho	4584	6	performed	perform	VBN
cord-006229-7yoilsho	4584	7	to	to	TO
cord-006229-7yoilsho	4584	8	reveal	reveal	VB
cord-006229-7yoilsho	4584	9	the	the	DT
cord-006229-7yoilsho	4584	10	underlying	underlying	JJ
cord-006229-7yoilsho	4584	11	mechanism	mechanism	NN
cord-006229-7yoilsho	4584	12	,	,	,
cord-006229-7yoilsho	4584	13	how	how	WRB
cord-006229-7yoilsho	4584	14	cell	cell	NN
cord-006229-7yoilsho	4584	15	sensitivity	sensitivity	NN
cord-006229-7yoilsho	4584	16	to	to	IN
cord-006229-7yoilsho	4584	17	IM	IM	NNP
cord-006229-7yoilsho	4584	18	is	be	VBZ
cord-006229-7yoilsho	4584	19	altered	alter	VBN
cord-006229-7yoilsho	4584	20	and	and	CC
cord-006229-7yoilsho	4584	21	if	if	IN
cord-006229-7yoilsho	4584	22	these	these	DT
cord-006229-7yoilsho	4584	23	effects	effect	NNS
cord-006229-7yoilsho	4584	24	occur	occur	VBP
cord-006229-7yoilsho	4584	25	due	due	IN
cord-006229-7yoilsho	4584	26	to	to	IN
cord-006229-7yoilsho	4584	27	a	a	DT
cord-006229-7yoilsho	4584	28	direct	direct	JJ
cord-006229-7yoilsho	4584	29	regulation	regulation	NN
cord-006229-7yoilsho	4584	30	of	of	IN
cord-006229-7yoilsho	4584	31	ABCG2	ABCG2	NNS
cord-006229-7yoilsho	4584	32	.	.	.
cord-006229-7yoilsho	4585	1	In	in	IN
cord-006229-7yoilsho	4585	2	summary	summary	NN
cord-006229-7yoilsho	4585	3	,	,	,
cord-006229-7yoilsho	4585	4	these	these	DT
cord-006229-7yoilsho	4585	5	findings	finding	NNS
cord-006229-7yoilsho	4585	6	could	could	MD
cord-006229-7yoilsho	4585	7	be	be	VB
cord-006229-7yoilsho	4585	8	relevant	relevant	JJ
cord-006229-7yoilsho	4585	9	in	in	IN
cord-006229-7yoilsho	4585	10	CML	CML	NNP
cord-006229-7yoilsho	4585	11	-	-	HYPH
cord-006229-7yoilsho	4585	12	therapy	therapy	NN
cord-006229-7yoilsho	4585	13	,	,	,
cord-006229-7yoilsho	4585	14	overcoming	overcome	VBG
cord-006229-7yoilsho	4585	15	IMresistances	IMresistances	NNPS
cord-006229-7yoilsho	4585	16	with	with	IN
cord-006229-7yoilsho	4585	17	a	a	DT
cord-006229-7yoilsho	4585	18	better	well	JJR
cord-006229-7yoilsho	4585	19	understanding	understanding	NN
cord-006229-7yoilsho	4585	20	of	of	IN
cord-006229-7yoilsho	4585	21	miRNA	miRNA	NNP
cord-006229-7yoilsho	4585	22	-	-	HYPH
cord-006229-7yoilsho	4585	23	and	and	CC
cord-006229-7yoilsho	4585	24	drug	drug	NN
cord-006229-7yoilsho	4585	25	transporter	transporter	NN
cord-006229-7yoilsho	4585	26	alteration	alteration	NN
cord-006229-7yoilsho	4585	27	in	in	IN
cord-006229-7yoilsho	4585	28	CML	CML	NNP
cord-006229-7yoilsho	4585	29	.	.	.
cord-006229-7yoilsho	4586	1	Acknowledgments	acknowledgment	NNS
cord-006229-7yoilsho	4586	2	:	:	:
cord-006229-7yoilsho	4586	3	We	-PRON-	PRP
cord-006229-7yoilsho	4586	4	would	would	MD
cord-006229-7yoilsho	4586	5	like	like	VB
cord-006229-7yoilsho	4586	6	to	to	TO
cord-006229-7yoilsho	4586	7	thank	thank	VB
cord-006229-7yoilsho	4586	8	all	all	PDT
cord-006229-7yoilsho	4586	9	the	the	DT
cord-006229-7yoilsho	4586	10	authors	author	NNS
cord-006229-7yoilsho	4586	11	for	for	IN
cord-006229-7yoilsho	4586	12	their	-PRON-	PRP$
cord-006229-7yoilsho	4586	13	contribution	contribution	NN
cord-006229-7yoilsho	4586	14	to	to	IN
cord-006229-7yoilsho	4586	15	this	this	DT
cord-006229-7yoilsho	4586	16	project	project	NN
cord-006229-7yoilsho	4586	17	.	.	.
cord-006229-7yoilsho	4587	1	This	this	DT
cord-006229-7yoilsho	4587	2	work	work	NN
cord-006229-7yoilsho	4587	3	was	be	VBD
cord-006229-7yoilsho	4587	4	funded	fund	VBN
cord-006229-7yoilsho	4587	5	by	by	IN
cord-006229-7yoilsho	4587	6	the	the	DT
cord-006229-7yoilsho	4587	7	University	University	NNP
cord-006229-7yoilsho	4587	8	Hospital	Hospital	NNP
cord-006229-7yoilsho	4587	9	Schleswig	Schleswig	NNP
cord-006229-7yoilsho	4587	10	-	-	HYPH
cord-006229-7yoilsho	4587	11	Holstein	Holstein	NNP
cord-006229-7yoilsho	4587	12	.	.	.
cord-006229-7yoilsho	4588	1	Oxidized	oxidize	VBN
cord-006229-7yoilsho	4588	2	silicon	silicon	NN
cord-006229-7yoilsho	4588	3	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	4588	4	and	and	CC
cord-006229-7yoilsho	4588	5	iron	iron	NN
cord-006229-7yoilsho	4588	6	oxide	oxide	NN
cord-006229-7yoilsho	4588	7	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	4588	8	for	for	IN
cord-006229-7yoilsho	4588	9	radiation	radiation	NN
cord-006229-7yoilsho	4588	10	therapy	therapy	NN
cord-006229-7yoilsho	4588	11	S.	S.	NNP
cord-006229-7yoilsho	4588	12	Klein	Klein	NNP
cord-006229-7yoilsho	4588	13	Radiation	Radiation	NNP
cord-006229-7yoilsho	4588	14	therapy	therapy	NN
cord-006229-7yoilsho	4588	15	often	often	RB
cord-006229-7yoilsho	4588	16	combined	combine	VBN
cord-006229-7yoilsho	4588	17	with	with	IN
cord-006229-7yoilsho	4588	18	surgery	surgery	NN
cord-006229-7yoilsho	4589	1	and/or	and/or	CC
cord-006229-7yoilsho	4590	1	chemotherapy	chemotherapy	NN
cord-006229-7yoilsho	4590	2	is	be	VBZ
cord-006229-7yoilsho	4590	3	applied	apply	VBN
cord-006229-7yoilsho	4590	4	to	to	IN
cord-006229-7yoilsho	4590	5	more	more	JJR
cord-006229-7yoilsho	4590	6	than	than	IN
cord-006229-7yoilsho	4590	7	50	50	CD
cord-006229-7yoilsho	4590	8	%	%	NN
cord-006229-7yoilsho	4590	9	of	of	IN
cord-006229-7yoilsho	4590	10	patients	patient	NNS
cord-006229-7yoilsho	4590	11	at	at	IN
cord-006229-7yoilsho	4590	12	some	some	DT
cord-006229-7yoilsho	4590	13	point	point	NN
cord-006229-7yoilsho	4590	14	of	of	IN
cord-006229-7yoilsho	4590	15	their	-PRON-	PRP$
cord-006229-7yoilsho	4590	16	treatment	treatment	NN
cord-006229-7yoilsho	4590	17	.	.	.
cord-006229-7yoilsho	4591	1	The	the	DT
cord-006229-7yoilsho	4591	2	cytotoxic	cytotoxic	JJ
cord-006229-7yoilsho	4591	3	effects	effect	NNS
cord-006229-7yoilsho	4591	4	of	of	IN
cord-006229-7yoilsho	4591	5	ionizing	ionize	VBG
cord-006229-7yoilsho	4591	6	radiation	radiation	NN
cord-006229-7yoilsho	4591	7	occur	occur	VBP
cord-006229-7yoilsho	4591	8	from	from	IN
cord-006229-7yoilsho	4591	9	their	-PRON-	PRP$
cord-006229-7yoilsho	4591	10	ability	ability	NN
cord-006229-7yoilsho	4591	11	to	to	TO
cord-006229-7yoilsho	4591	12	produce	produce	VB
cord-006229-7yoilsho	4591	13	DNA	dna	NN
cord-006229-7yoilsho	4591	14	double	double	JJ
cord-006229-7yoilsho	4591	15	-	-	HYPH
cord-006229-7yoilsho	4591	16	strand	strand	NN
cord-006229-7yoilsho	4591	17	breaks	break	NNS
cord-006229-7yoilsho	4591	18	through	through	IN
cord-006229-7yoilsho	4591	19	the	the	DT
cord-006229-7yoilsho	4591	20	formation	formation	NN
cord-006229-7yoilsho	4591	21	of	of	IN
cord-006229-7yoilsho	4591	22	free	free	JJ
cord-006229-7yoilsho	4591	23	radicals	radical	NNS
cord-006229-7yoilsho	4591	24	within	within	IN
cord-006229-7yoilsho	4591	25	cells	cell	NNS
cord-006229-7yoilsho	4591	26	.	.	.
cord-006229-7yoilsho	4592	1	However	however	RB
cord-006229-7yoilsho	4592	2	,	,	,
cord-006229-7yoilsho	4592	3	the	the	DT
cord-006229-7yoilsho	4592	4	curative	curative	JJ
cord-006229-7yoilsho	4592	5	potential	potential	NN
cord-006229-7yoilsho	4592	6	of	of	IN
cord-006229-7yoilsho	4592	7	radiotherapy	radiotherapy	NN
cord-006229-7yoilsho	4592	8	is	be	VBZ
cord-006229-7yoilsho	4592	9	often	often	RB
cord-006229-7yoilsho	4592	10	limited	limit	VBN
cord-006229-7yoilsho	4592	11	by	by	IN
cord-006229-7yoilsho	4592	12	intrinsic	intrinsic	JJ
cord-006229-7yoilsho	4592	13	radio	radio	NN
cord-006229-7yoilsho	4592	14	resistance	resistance	NN
cord-006229-7yoilsho	4592	15	of	of	IN
cord-006229-7yoilsho	4592	16	cancer	cancer	NN
cord-006229-7yoilsho	4592	17	cells	cell	NNS
cord-006229-7yoilsho	4592	18	and	and	CC
cord-006229-7yoilsho	4592	19	normal	normal	JJ
cord-006229-7yoilsho	4592	20	tissue	tissue	NN
cord-006229-7yoilsho	4592	21	toxicity	toxicity	NN
cord-006229-7yoilsho	4592	22	.	.	.
cord-006229-7yoilsho	4593	1	To	to	TO
cord-006229-7yoilsho	4593	2	overcome	overcome	VB
cord-006229-7yoilsho	4593	3	this	this	DT
cord-006229-7yoilsho	4593	4	resistance	resistance	NN
cord-006229-7yoilsho	4593	5	and	and	CC
cord-006229-7yoilsho	4593	6	enhance	enhance	VB
cord-006229-7yoilsho	4593	7	the	the	DT
cord-006229-7yoilsho	4593	8	effectiveness	effectiveness	NN
cord-006229-7yoilsho	4593	9	of	of	IN
cord-006229-7yoilsho	4593	10	ionizing	ionize	VBG
cord-006229-7yoilsho	4593	11	radiation	radiation	NN
cord-006229-7yoilsho	4593	12	,	,	,
cord-006229-7yoilsho	4593	13	radio	radio	NN
cord-006229-7yoilsho	4593	14	sensitizers	sensitizer	NNS
cord-006229-7yoilsho	4593	15	are	be	VBP
cord-006229-7yoilsho	4593	16	used	use	VBN
cord-006229-7yoilsho	4593	17	in	in	IN
cord-006229-7yoilsho	4593	18	combination	combination	NN
cord-006229-7yoilsho	4593	19	with	with	IN
cord-006229-7yoilsho	4593	20	radiotherapy	radiotherapy	NN
cord-006229-7yoilsho	4593	21	.	.	.
cord-006229-7yoilsho	4594	1	In	in	IN
cord-006229-7yoilsho	4594	2	our	-PRON-	PRP$
cord-006229-7yoilsho	4594	3	studies	study	NNS
cord-006229-7yoilsho	4594	4	we	-PRON-	PRP
cord-006229-7yoilsho	4594	5	used	use	VBD
cord-006229-7yoilsho	4594	6	amino	amino	NN
cord-006229-7yoilsho	4594	7	functionalized	functionalize	VBN
cord-006229-7yoilsho	4594	8	,	,	,
cord-006229-7yoilsho	4594	9	oxidized	oxidize	VBN
cord-006229-7yoilsho	4594	10	silicon	silicon	NN
cord-006229-7yoilsho	4594	11	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	4594	12	(	(	-LRB-
cord-006229-7yoilsho	4594	13	SiNP	SiNP	NNP
cord-006229-7yoilsho	4594	14	)	)	-RRB-
cord-006229-7yoilsho	4594	15	,	,	,
cord-006229-7yoilsho	4594	16	superparamagnetic	superparamagnetic	JJ
cord-006229-7yoilsho	4594	17	iron	iron	NN
cord-006229-7yoilsho	4594	18	oxide	oxide	NN
cord-006229-7yoilsho	4594	19	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	4594	20	(	(	-LRB-
cord-006229-7yoilsho	4594	21	SPION	SPION	NNP
cord-006229-7yoilsho	4594	22	)	)	-RRB-
cord-006229-7yoilsho	4594	23	and	and	CC
cord-006229-7yoilsho	4594	24	iron	iron	NN
cord-006229-7yoilsho	4594	25	doped	dope	VBN
cord-006229-7yoilsho	4594	26	silicon	silicon	NN
cord-006229-7yoilsho	4594	27	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	4594	28	(	(	-LRB-
cord-006229-7yoilsho	4594	29	Fe(1%)-SiNP	Fe(1%)-SiNP	NNP
cord-006229-7yoilsho	4594	30	)	)	-RRB-
cord-006229-7yoilsho	4595	1	to	to	TO
cord-006229-7yoilsho	4595	2	increase	increase	VB
cord-006229-7yoilsho	4595	3	the	the	DT
cord-006229-7yoilsho	4595	4	formation	formation	NN
cord-006229-7yoilsho	4595	5	of	of	IN
cord-006229-7yoilsho	4595	6	reactive	reactive	JJ
cord-006229-7yoilsho	4595	7	oxygen	oxygen	NN
cord-006229-7yoilsho	4595	8	species	specie	NNS
cord-006229-7yoilsho	4595	9	(	(	-LRB-
cord-006229-7yoilsho	4595	10	ROS	ROS	NNP
cord-006229-7yoilsho	4595	11	)	)	-RRB-
cord-006229-7yoilsho	4595	12	in	in	IN
cord-006229-7yoilsho	4595	13	cells	cell	NNS
cord-006229-7yoilsho	4595	14	.	.	.
cord-006229-7yoilsho	4596	1	Cancer	cancer	NN
cord-006229-7yoilsho	4596	2	and	and	CC
cord-006229-7yoilsho	4596	3	tissue	tissue	NN
cord-006229-7yoilsho	4596	4	cells	cell	NNS
cord-006229-7yoilsho	4596	5	loaded	load	VBN
cord-006229-7yoilsho	4596	6	with	with	IN
cord-006229-7yoilsho	4596	7	the	the	DT
cord-006229-7yoilsho	4596	8	various	various	JJ
cord-006229-7yoilsho	4596	9	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	4596	10	were	be	VBD
cord-006229-7yoilsho	4596	11	irradiated	irradiate	VBN
cord-006229-7yoilsho	4596	12	with	with	IN
cord-006229-7yoilsho	4596	13	a	a	DT
cord-006229-7yoilsho	4596	14	single	single	JJ
cord-006229-7yoilsho	4596	15	dose	dose	NN
cord-006229-7yoilsho	4596	16	of	of	IN
cord-006229-7yoilsho	4596	17	1	1	CD
cord-006229-7yoilsho	4596	18	-	-	SYM
cord-006229-7yoilsho	4596	19	3	3	CD
cord-006229-7yoilsho	4596	20	Gy	Gy	NNP
cord-006229-7yoilsho	4596	21	using	use	VBG
cord-006229-7yoilsho	4596	22	a	a	DT
cord-006229-7yoilsho	4596	23	120	120	CD
cord-006229-7yoilsho	4596	24	kV	kV	NNP
cord-006229-7yoilsho	4596	25	X	X	NNP
cord-006229-7yoilsho	4596	26	-	-	HYPH
cord-006229-7yoilsho	4596	27	Ray	Ray	NNP
cord-006229-7yoilsho	4596	28	tube	tube	NN
cord-006229-7yoilsho	4596	29	.	.	.
cord-006229-7yoilsho	4597	1	After	after	IN
cord-006229-7yoilsho	4597	2	irradiation	irradiation	NN
cord-006229-7yoilsho	4597	3	,	,	,
cord-006229-7yoilsho	4597	4	the	the	DT
cord-006229-7yoilsho	4597	5	formation	formation	NN
cord-006229-7yoilsho	4597	6	of	of	IN
cord-006229-7yoilsho	4597	7	the	the	DT
cord-006229-7yoilsho	4597	8	different	different	JJ
cord-006229-7yoilsho	4597	9	ROS	ROS	NNP
cord-006229-7yoilsho	4597	10	species	specie	NNS
cord-006229-7yoilsho	4597	11	including	include	VBG
cord-006229-7yoilsho	4597	12	superoxide	superoxide	NN
cord-006229-7yoilsho	4597	13	,	,	,
cord-006229-7yoilsho	4597	14	hydroxyl	hydroxyl	NN
cord-006229-7yoilsho	4597	15	radicals	radical	NNS
cord-006229-7yoilsho	4597	16	and	and	CC
cord-006229-7yoilsho	4597	17	singlet	singlet	NN
cord-006229-7yoilsho	4597	18	oxygen	oxygen	NN
cord-006229-7yoilsho	4597	19	was	be	VBD
cord-006229-7yoilsho	4597	20	investigated	investigate	VBN
cord-006229-7yoilsho	4597	21	.	.	.
cord-006229-7yoilsho	4598	1	SiNPs	sinps	RB
cord-006229-7yoilsho	4598	2	with	with	IN
cord-006229-7yoilsho	4598	3	sizes	size	NNS
cord-006229-7yoilsho	4598	4	around	around	IN
cord-006229-7yoilsho	4598	5	1	1	CD
cord-006229-7yoilsho	4598	6	nm	nm	NN
cord-006229-7yoilsho	4598	7	can	can	MD
cord-006229-7yoilsho	4598	8	easily	easily	RB
cord-006229-7yoilsho	4598	9	cross	cross	VB
cord-006229-7yoilsho	4598	10	the	the	DT
cord-006229-7yoilsho	4598	11	cell	cell	NN
cord-006229-7yoilsho	4598	12	and	and	CC
cord-006229-7yoilsho	4598	13	nuclear	nuclear	JJ
cord-006229-7yoilsho	4598	14	membrane	membrane	NN
cord-006229-7yoilsho	4598	15	.	.	.
cord-006229-7yoilsho	4599	1	The	the	DT
cord-006229-7yoilsho	4599	2	positively	positively	RB
cord-006229-7yoilsho	4599	3	charged	charge	VBN
cord-006229-7yoilsho	4599	4	amino	amino	NN
cord-006229-7yoilsho	4599	5	functionalized	functionalize	VBN
cord-006229-7yoilsho	4599	6	SiNPs	SiNPs	NNP
cord-006229-7yoilsho	4599	7	stick	stick	VBP
cord-006229-7yoilsho	4599	8	in	in	IN
cord-006229-7yoilsho	4599	9	all	all	DT
cord-006229-7yoilsho	4599	10	membranes	membrane	NNS
cord-006229-7yoilsho	4599	11	as	as	RB
cord-006229-7yoilsho	4599	12	well	well	RB
cord-006229-7yoilsho	4599	13	in	in	IN
cord-006229-7yoilsho	4599	14	those	those	DT
cord-006229-7yoilsho	4599	15	of	of	IN
cord-006229-7yoilsho	4599	16	the	the	DT
cord-006229-7yoilsho	4599	17	mitochondria	mitochondrion	NNS
cord-006229-7yoilsho	4599	18	.	.	.
cord-006229-7yoilsho	4600	1	Irradiation	irradiation	NN
cord-006229-7yoilsho	4600	2	of	of	IN
cord-006229-7yoilsho	4600	3	the	the	DT
cord-006229-7yoilsho	4600	4	mitochondria	mitochondrion	NNS
cord-006229-7yoilsho	4600	5	may	may	MD
cord-006229-7yoilsho	4600	6	cause	cause	VB
cord-006229-7yoilsho	4600	7	the	the	DT
cord-006229-7yoilsho	4600	8	depolarization	depolarization	NN
cord-006229-7yoilsho	4600	9	of	of	IN
cord-006229-7yoilsho	4600	10	the	the	DT
cord-006229-7yoilsho	4600	11	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	4600	12	membrane	membrane	NN
cord-006229-7yoilsho	4600	13	,	,	,
cord-006229-7yoilsho	4600	14	which	which	WDT
cord-006229-7yoilsho	4600	15	enables	enable	VBZ
cord-006229-7yoilsho	4600	16	the	the	DT
cord-006229-7yoilsho	4600	17	release	release	NN
cord-006229-7yoilsho	4600	18	of	of	IN
cord-006229-7yoilsho	4600	19	cytochrome	cytochrome	NN
cord-006229-7yoilsho	4600	20	c	c	NN
cord-006229-7yoilsho	4600	21	and	and	CC
cord-006229-7yoilsho	4600	22	simultaneously	simultaneously	RB
cord-006229-7yoilsho	4600	23	,	,	,
cord-006229-7yoilsho	4600	24	an	an	DT
cord-006229-7yoilsho	4600	25	inhibition	inhibition	NN
cord-006229-7yoilsho	4600	26	of	of	IN
cord-006229-7yoilsho	4600	27	the	the	DT
cord-006229-7yoilsho	4600	28	respiratory	respiratory	JJ
cord-006229-7yoilsho	4600	29	chain	chain	NN
cord-006229-7yoilsho	4600	30	,	,	,
cord-006229-7yoilsho	4600	31	which	which	WDT
cord-006229-7yoilsho	4600	32	leads	lead	VBZ
cord-006229-7yoilsho	4600	33	to	to	IN
cord-006229-7yoilsho	4600	34	an	an	DT
cord-006229-7yoilsho	4600	35	increased	increase	VBN
cord-006229-7yoilsho	4600	36	generation	generation	NN
cord-006229-7yoilsho	4600	37	of	of	IN
cord-006229-7yoilsho	4600	38	superoxide	superoxide	NN
cord-006229-7yoilsho	4600	39	.	.	.
cord-006229-7yoilsho	4601	1	Amino	amino	NN
cord-006229-7yoilsho	4601	2	functionalized	functionalize	VBN
cord-006229-7yoilsho	4601	3	SiNPs	SiNPs	NNPS
cord-006229-7yoilsho	4601	4	,	,	,
cord-006229-7yoilsho	4601	5	as	as	IN
cord-006229-7yoilsho	4601	6	being	be	VBG
cord-006229-7yoilsho	4601	7	embedded	embed	VBN
cord-006229-7yoilsho	4601	8	in	in	IN
cord-006229-7yoilsho	4601	9	the	the	DT
cord-006229-7yoilsho	4601	10	outer	outer	JJ
cord-006229-7yoilsho	4601	11	mitochondrial	mitochondrial	NN
cord-006229-7yoilsho	4601	12	membrane	membrane	NN
cord-006229-7yoilsho	4601	13	,	,	,
cord-006229-7yoilsho	4601	14	evidently	evidently	RB
cord-006229-7yoilsho	4601	15	enhance	enhance	VB
cord-006229-7yoilsho	4601	16	the	the	DT
cord-006229-7yoilsho	4601	17	depolarizing	depolarizing	JJ
cord-006229-7yoilsho	4601	18	effect	effect	NN
cord-006229-7yoilsho	4601	19	of	of	IN
cord-006229-7yoilsho	4601	20	the	the	DT
cord-006229-7yoilsho	4601	21	X	x	NN
cord-006229-7yoilsho	4601	22	-	-	NN
cord-006229-7yoilsho	4601	23	ray	ray	JJ
cord-006229-7yoilsho	4601	24	radiation	radiation	NN
cord-006229-7yoilsho	4601	25	on	on	IN
cord-006229-7yoilsho	4601	26	the	the	DT
cord-006229-7yoilsho	4601	27	mitochondria	mitochondrion	NNS
cord-006229-7yoilsho	4601	28	and	and	CC
cord-006229-7yoilsho	4601	29	therefore	therefore	RB
cord-006229-7yoilsho	4601	30	increase	increase	VB
cord-006229-7yoilsho	4601	31	the	the	DT
cord-006229-7yoilsho	4601	32	concentration	concentration	NN
cord-006229-7yoilsho	4601	33	of	of	IN
cord-006229-7yoilsho	4601	34	superoxide	superoxide	NN
cord-006229-7yoilsho	4601	35	.	.	.
cord-006229-7yoilsho	4602	1	[	[	-LRB-
cord-006229-7yoilsho	4602	2	1	1	LS
cord-006229-7yoilsho	4602	3	]	]	-RRB-
cord-006229-7yoilsho	4602	4	Oxidized	oxidize	VBN
cord-006229-7yoilsho	4602	5	SiNPs	sinps	RB
cord-006229-7yoilsho	4602	6	with	with	IN
cord-006229-7yoilsho	4602	7	larger	large	JJR
cord-006229-7yoilsho	4602	8	sizes	size	NNS
cord-006229-7yoilsho	4602	9	accumulate	accumulate	VBP
cord-006229-7yoilsho	4602	10	in	in	IN
cord-006229-7yoilsho	4602	11	the	the	DT
cord-006229-7yoilsho	4602	12	cytoplasm	cytoplasm	NN
cord-006229-7yoilsho	4602	13	and	and	CC
cord-006229-7yoilsho	4602	14	generate	generate	VB
cord-006229-7yoilsho	4603	1	mainly	mainly	RB
cord-006229-7yoilsho	4603	2	singlet	singlet	JJ
cord-006229-7yoilsho	4603	3	oxygen	oxygen	NN
cord-006229-7yoilsho	4603	4	after	after	IN
cord-006229-7yoilsho	4603	5	irradiation	irradiation	NN
cord-006229-7yoilsho	4603	6	.	.	.
cord-006229-7yoilsho	4604	1	SPIONs	spion	NNS
cord-006229-7yoilsho	4604	2	enter	enter	VBP
cord-006229-7yoilsho	4604	3	the	the	DT
cord-006229-7yoilsho	4604	4	cells	cell	NNS
cord-006229-7yoilsho	4604	5	via	via	IN
cord-006229-7yoilsho	4604	6	endocytosis	endocytosis	NN
cord-006229-7yoilsho	4604	7	,	,	,
cord-006229-7yoilsho	4604	8	whereas	whereas	IN
cord-006229-7yoilsho	4604	9	the	the	DT
cord-006229-7yoilsho	4604	10	uncoated	uncoated	JJ
cord-006229-7yoilsho	4604	11	SPIONs	spion	NNS
cord-006229-7yoilsho	4604	12	remain	remain	VBP
cord-006229-7yoilsho	4604	13	in	in	IN
cord-006229-7yoilsho	4604	14	the	the	DT
cord-006229-7yoilsho	4604	15	vesicles	vesicle	NNS
cord-006229-7yoilsho	4604	16	and	and	CC
cord-006229-7yoilsho	4604	17	the	the	DT
cord-006229-7yoilsho	4604	18	citrate	citrate	NN
cord-006229-7yoilsho	4604	19	coated	coated	JJ
cord-006229-7yoilsho	4604	20	SPIONs	spion	NNS
cord-006229-7yoilsho	4604	21	accumulate	accumulate	VBP
cord-006229-7yoilsho	4604	22	in	in	IN
cord-006229-7yoilsho	4604	23	the	the	DT
cord-006229-7yoilsho	4604	24	cytoplasm	cytoplasm	NN
cord-006229-7yoilsho	4604	25	.	.	.
cord-006229-7yoilsho	4605	1	Cells	cell	NNS
cord-006229-7yoilsho	4605	2	loaded	load	VBN
cord-006229-7yoilsho	4605	3	with	with	IN
cord-006229-7yoilsho	4605	4	citrate	citrate	NN
cord-006229-7yoilsho	4605	5	coated	coated	JJ
cord-006229-7yoilsho	4605	6	SPIONs	spion	NNS
cord-006229-7yoilsho	4605	7	show	show	VBP
cord-006229-7yoilsho	4605	8	no	no	DT
cord-006229-7yoilsho	4605	9	higher	high	JJR
cord-006229-7yoilsho	4605	10	ROS	ROS	NNP
cord-006229-7yoilsho	4605	11	concentration	concentration	NN
cord-006229-7yoilsho	4605	12	than	than	IN
cord-006229-7yoilsho	4605	13	in	in	IN
cord-006229-7yoilsho	4605	14	media	media	NN
cord-006229-7yoilsho	4605	15	-	-	HYPH
cord-006229-7yoilsho	4605	16	cultured	cultured	JJ
cord-006229-7yoilsho	4605	17	cells	cell	NNS
cord-006229-7yoilsho	4605	18	.	.	.
cord-006229-7yoilsho	4606	1	But	but	CC
cord-006229-7yoilsho	4606	2	after	after	IN
cord-006229-7yoilsho	4606	3	irradiation	irradiation	NN
cord-006229-7yoilsho	4606	4	,	,	,
cord-006229-7yoilsho	4606	5	the	the	DT
cord-006229-7yoilsho	4606	6	ROS	ROS	NNP
cord-006229-7yoilsho	4606	7	formation	formation	NN
cord-006229-7yoilsho	4606	8	increased	increase	VBD
cord-006229-7yoilsho	4606	9	drastically	drastically	RB
cord-006229-7yoilsho	4606	10	.	.	.
cord-006229-7yoilsho	4607	1	This	this	DT
cord-006229-7yoilsho	4607	2	enhancing	enhance	VBG
cord-006229-7yoilsho	4607	3	effect	effect	NN
cord-006229-7yoilsho	4607	4	is	be	VBZ
cord-006229-7yoilsho	4607	5	explained	explain	VBN
cord-006229-7yoilsho	4607	6	with	with	IN
cord-006229-7yoilsho	4607	7	the	the	DT
cord-006229-7yoilsho	4607	8	impact	impact	NN
cord-006229-7yoilsho	4607	9	of	of	IN
cord-006229-7yoilsho	4607	10	X	X	NNS
cord-006229-7yoilsho	4607	11	-	-	NNS
cord-006229-7yoilsho	4607	12	rays	ray	NNS
cord-006229-7yoilsho	4607	13	onto	onto	IN
cord-006229-7yoilsho	4607	14	the	the	DT
cord-006229-7yoilsho	4607	15	surface	surface	NN
cord-006229-7yoilsho	4607	16	of	of	IN
cord-006229-7yoilsho	4607	17	SPIONs	spion	NNS
cord-006229-7yoilsho	4607	18	which	which	WDT
cord-006229-7yoilsho	4607	19	is	be	VBZ
cord-006229-7yoilsho	4607	20	due	due	JJ
cord-006229-7yoilsho	4607	21	to	to	IN
cord-006229-7yoilsho	4607	22	the	the	DT
cord-006229-7yoilsho	4607	23	destruction	destruction	NN
cord-006229-7yoilsho	4607	24	of	of	IN
cord-006229-7yoilsho	4607	25	surface	surface	NN
cord-006229-7yoilsho	4607	26	structures	structure	NNS
cord-006229-7yoilsho	4607	27	.	.	.
cord-006229-7yoilsho	4608	1	The	the	DT
cord-006229-7yoilsho	4608	2	freed	free	VBN
cord-006229-7yoilsho	4608	3	SPION	spion	NN
cord-006229-7yoilsho	4608	4	surface	surface	NN
cord-006229-7yoilsho	4608	5	contains	contain	VBZ
cord-006229-7yoilsho	4608	6	easier	easy	JJR
cord-006229-7yoilsho	4608	7	accessible	accessible	JJ
cord-006229-7yoilsho	4608	8	iron	iron	NN
cord-006229-7yoilsho	4608	9	ions	ion	NNS
cord-006229-7yoilsho	4608	10	.	.	.
cord-006229-7yoilsho	4609	1	This	this	DT
cord-006229-7yoilsho	4609	2	ions	ion	NNS
cord-006229-7yoilsho	4609	3	can	can	MD
cord-006229-7yoilsho	4609	4	participate	participate	VB
cord-006229-7yoilsho	4609	5	in	in	IN
cord-006229-7yoilsho	4609	6	the	the	DT
cord-006229-7yoilsho	4609	7	Fenton	Fenton	NNP
cord-006229-7yoilsho	4609	8	and	and	CC
cord-006229-7yoilsho	4609	9	Haber	Haber	NNP
cord-006229-7yoilsho	4609	10	-	-	HYPH
cord-006229-7yoilsho	4609	11	Weiss	Weiss	NNP
cord-006229-7yoilsho	4609	12	chemistry	chemistry	NN
cord-006229-7yoilsho	4609	13	and	and	CC
cord-006229-7yoilsho	4609	14	thus	thus	RB
cord-006229-7yoilsho	4609	15	,	,	,
cord-006229-7yoilsho	4609	16	catalyze	catalyze	VB
cord-006229-7yoilsho	4609	17	the	the	DT
cord-006229-7yoilsho	4609	18	hydroxyl	hydroxyl	NN
cord-006229-7yoilsho	4609	19	radical	radical	JJ
cord-006229-7yoilsho	4609	20	formation	formation	NN
cord-006229-7yoilsho	4609	21	.	.	.
cord-006229-7yoilsho	4610	1	[	[	-LRB-
cord-006229-7yoilsho	4610	2	2	2	CD
cord-006229-7yoilsho	4610	3	]	]	-RRB-
cord-006229-7yoilsho	4610	4	1	1	CD
cord-006229-7yoilsho	4610	5	to	to	TO
cord-006229-7yoilsho	4610	6	5	5	CD
cord-006229-7yoilsho	4610	7	%	%	NN
cord-006229-7yoilsho	4610	8	iron	iron	NN
cord-006229-7yoilsho	4610	9	doped	dope	VBN
cord-006229-7yoilsho	4610	10	SiNP	SiNP	NNP
cord-006229-7yoilsho	4610	11	increase	increase	VB
cord-006229-7yoilsho	4610	12	the	the	DT
cord-006229-7yoilsho	4610	13	formation	formation	NN
cord-006229-7yoilsho	4610	14	of	of	IN
cord-006229-7yoilsho	4610	15	hydroxyl	hydroxyl	NN
cord-006229-7yoilsho	4610	16	radicals	radical	NNS
cord-006229-7yoilsho	4610	17	as	as	RB
cord-006229-7yoilsho	4610	18	well	well	RB
cord-006229-7yoilsho	4610	19	as	as	IN
cord-006229-7yoilsho	4610	20	the	the	DT
cord-006229-7yoilsho	4610	21	generation	generation	NN
cord-006229-7yoilsho	4610	22	of	of	IN
cord-006229-7yoilsho	4610	23	singlet	singlet	NN
cord-006229-7yoilsho	4610	24	oxygen	oxygen	NN
cord-006229-7yoilsho	4610	25	after	after	IN
cord-006229-7yoilsho	4610	26	irradiation	irradiation	NN
cord-006229-7yoilsho	4610	27	.	.	.
cord-006229-7yoilsho	4611	1	Chronic	chronic	JJ
cord-006229-7yoilsho	4611	2	pain	pain	NN
cord-006229-7yoilsho	4611	3	in	in	IN
cord-006229-7yoilsho	4611	4	response	response	NN
cord-006229-7yoilsho	4611	5	to	to	IN
cord-006229-7yoilsho	4611	6	tissue	tissue	NN
cord-006229-7yoilsho	4611	7	damage	damage	NN
cord-006229-7yoilsho	4611	8	(	(	-LRB-
cord-006229-7yoilsho	4611	9	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	4611	10	pain	pain	NN
cord-006229-7yoilsho	4611	11	)	)	-RRB-
cord-006229-7yoilsho	4611	12	or	or	CC
cord-006229-7yoilsho	4611	13	nerve	nerve	NN
cord-006229-7yoilsho	4611	14	injury	injury	NN
cord-006229-7yoilsho	4611	15	(	(	-LRB-
cord-006229-7yoilsho	4611	16	neuropathic	neuropathic	JJ
cord-006229-7yoilsho	4611	17	pain	pain	NN
cord-006229-7yoilsho	4611	18	)	)	-RRB-
cord-006229-7yoilsho	4612	1	is	be	VBZ
cord-006229-7yoilsho	4612	2	a	a	DT
cord-006229-7yoilsho	4612	3	major	major	JJ
cord-006229-7yoilsho	4612	4	clinical	clinical	JJ
cord-006229-7yoilsho	4612	5	health	health	NN
cord-006229-7yoilsho	4612	6	problem	problem	NN
cord-006229-7yoilsho	4612	7	,	,	,
cord-006229-7yoilsho	4612	8	affecting	affect	VBG
cord-006229-7yoilsho	4612	9	up	up	IN
cord-006229-7yoilsho	4612	10	to	to	TO
cord-006229-7yoilsho	4612	11	30	30	CD
cord-006229-7yoilsho	4612	12	%	%	NN
cord-006229-7yoilsho	4612	13	of	of	IN
cord-006229-7yoilsho	4612	14	adults	adult	NNS
cord-006229-7yoilsho	4612	15	worldwide	worldwide	RB
cord-006229-7yoilsho	4612	16	.	.	.
cord-006229-7yoilsho	4613	1	Currently	currently	RB
cord-006229-7yoilsho	4613	2	available	available	JJ
cord-006229-7yoilsho	4613	3	treatments	treatment	NNS
cord-006229-7yoilsho	4613	4	are	be	VBP
cord-006229-7yoilsho	4613	5	only	only	RB
cord-006229-7yoilsho	4613	6	partially	partially	RB
cord-006229-7yoilsho	4613	7	susceptible	susceptible	JJ
cord-006229-7yoilsho	4613	8	and	and	CC
cord-006229-7yoilsho	4613	9	are	be	VBP
cord-006229-7yoilsho	4613	10	accompanied	accompany	VBN
cord-006229-7yoilsho	4613	11	with	with	IN
cord-006229-7yoilsho	4613	12	therapy	therapy	NN
cord-006229-7yoilsho	4613	13	limiting	limit	VBG
cord-006229-7yoilsho	4613	14	side	side	NN
cord-006229-7yoilsho	4613	15	effects	effect	NNS
cord-006229-7yoilsho	4613	16	.	.	.
cord-006229-7yoilsho	4614	1	Thus	thus	RB
cord-006229-7yoilsho	4614	2	it	-PRON-	PRP
cord-006229-7yoilsho	4614	3	is	be	VBZ
cord-006229-7yoilsho	4614	4	important	important	JJ
cord-006229-7yoilsho	4614	5	to	to	TO
cord-006229-7yoilsho	4614	6	elucidate	elucidate	VB
cord-006229-7yoilsho	4614	7	molecular	molecular	JJ
cord-006229-7yoilsho	4614	8	mechanisms	mechanism	NNS
cord-006229-7yoilsho	4614	9	of	of	IN
cord-006229-7yoilsho	4614	10	pain	pain	NN
cord-006229-7yoilsho	4614	11	signaling	signal	VBG
cord-006229-7yoilsho	4614	12	in	in	IN
cord-006229-7yoilsho	4614	13	detail	detail	NN
cord-006229-7yoilsho	4614	14	to	to	TO
cord-006229-7yoilsho	4614	15	obtain	obtain	VB
cord-006229-7yoilsho	4614	16	new	new	JJ
cord-006229-7yoilsho	4614	17	insights	insight	NNS
cord-006229-7yoilsho	4614	18	in	in	IN
cord-006229-7yoilsho	4614	19	potential	potential	JJ
cord-006229-7yoilsho	4614	20	future	future	JJ
cord-006229-7yoilsho	4614	21	therapies	therapy	NNS
cord-006229-7yoilsho	4614	22	.	.	.
cord-006229-7yoilsho	4615	1	Recent	recent	JJ
cord-006229-7yoilsho	4615	2	data	datum	NNS
cord-006229-7yoilsho	4615	3	indicate	indicate	VBP
cord-006229-7yoilsho	4615	4	that	that	IN
cord-006229-7yoilsho	4615	5	hydrogen	hydrogen	NN
cord-006229-7yoilsho	4615	6	sulfide	sulfide	NN
cord-006229-7yoilsho	4615	7	(	(	-LRB-
cord-006229-7yoilsho	4615	8	H	h	NN
cord-006229-7yoilsho	4615	9	2	2	CD
cord-006229-7yoilsho	4615	10	S	S	NNP
cord-006229-7yoilsho	4615	11	)	)	-RRB-
cord-006229-7yoilsho	4615	12	contributes	contribute	VBZ
cord-006229-7yoilsho	4615	13	to	to	IN
cord-006229-7yoilsho	4615	14	the	the	DT
cord-006229-7yoilsho	4615	15	processing	processing	NN
cord-006229-7yoilsho	4615	16	of	of	IN
cord-006229-7yoilsho	4615	17	chronic	chronic	JJ
cord-006229-7yoilsho	4615	18	pain	pain	NN
cord-006229-7yoilsho	4615	19	,	,	,
cord-006229-7yoilsho	4615	20	however	however	RB
cord-006229-7yoilsho	4615	21	pro	pro	JJ
cord-006229-7yoilsho	4615	22	-	-	:
cord-006229-7yoilsho	4615	23	as	as	RB
cord-006229-7yoilsho	4615	24	well	well	RB
cord-006229-7yoilsho	4615	25	as	as	IN
cord-006229-7yoilsho	4615	26	antinociceptive	antinociceptive	JJ
cord-006229-7yoilsho	4615	27	effects	effect	NNS
cord-006229-7yoilsho	4615	28	have	have	VBP
cord-006229-7yoilsho	4615	29	been	be	VBN
cord-006229-7yoilsho	4615	30	described	describe	VBN
cord-006229-7yoilsho	4615	31	so	so	RB
cord-006229-7yoilsho	4615	32	far	far	RB
cord-006229-7yoilsho	4615	33	.	.	.
cord-006229-7yoilsho	4616	1	Moreover	moreover	RB
cord-006229-7yoilsho	4616	2	the	the	DT
cord-006229-7yoilsho	4616	3	sources	source	NNS
cord-006229-7yoilsho	4616	4	of	of	IN
cord-006229-7yoilsho	4616	5	H	H	NNP
cord-006229-7yoilsho	4616	6	2	2	CD
cord-006229-7yoilsho	4616	7	S	S	NNP
cord-006229-7yoilsho	4616	8	production	production	NN
cord-006229-7yoilsho	4616	9	in	in	IN
cord-006229-7yoilsho	4616	10	the	the	DT
cord-006229-7yoilsho	4616	11	nociceptive	nociceptive	JJ
cord-006229-7yoilsho	4616	12	system	system	NN
cord-006229-7yoilsho	4616	13	are	be	VBP
cord-006229-7yoilsho	4616	14	only	only	RB
cord-006229-7yoilsho	4616	15	poorly	poorly	RB
cord-006229-7yoilsho	4616	16	understood	understand	VBN
cord-006229-7yoilsho	4616	17	.	.	.
cord-006229-7yoilsho	4617	1	Here	here	RB
cord-006229-7yoilsho	4617	2	we	-PRON-	PRP
cord-006229-7yoilsho	4617	3	investigated	investigate	VBD
cord-006229-7yoilsho	4617	4	the	the	DT
cord-006229-7yoilsho	4617	5	expression	expression	NN
cord-006229-7yoilsho	4617	6	of	of	IN
cord-006229-7yoilsho	4617	7	the	the	DT
cord-006229-7yoilsho	4617	8	H	H	NNP
cord-006229-7yoilsho	4617	9	2	2	CD
cord-006229-7yoilsho	4617	10	S	S	NNP
cord-006229-7yoilsho	4617	11	releasing	release	VBG
cord-006229-7yoilsho	4617	12	enzyme	enzyme	NN
cord-006229-7yoilsho	4617	13	cystathionine	cystathionine	NN
cord-006229-7yoilsho	4617	14	g	g	NN
cord-006229-7yoilsho	4617	15	-	-	HYPH
cord-006229-7yoilsho	4617	16	lyase	lyase	NN
cord-006229-7yoilsho	4617	17	(	(	-LRB-
cord-006229-7yoilsho	4617	18	CSE	CSE	NNP
cord-006229-7yoilsho	4617	19	)	)	-RRB-
cord-006229-7yoilsho	4617	20	in	in	IN
cord-006229-7yoilsho	4617	21	the	the	DT
cord-006229-7yoilsho	4617	22	nociceptive	nociceptive	JJ
cord-006229-7yoilsho	4617	23	system	system	NN
cord-006229-7yoilsho	4617	24	and	and	CC
cord-006229-7yoilsho	4617	25	characterized	characterize	VBD
cord-006229-7yoilsho	4617	26	its	-PRON-	PRP$
cord-006229-7yoilsho	4617	27	role	role	NN
cord-006229-7yoilsho	4617	28	in	in	IN
cord-006229-7yoilsho	4617	29	chronic	chronic	JJ
cord-006229-7yoilsho	4617	30	pain	pain	NN
cord-006229-7yoilsho	4617	31	signaling	signal	VBG
cord-006229-7yoilsho	4617	32	using	use	VBG
cord-006229-7yoilsho	4617	33	CSE	CSE	NNP
cord-006229-7yoilsho	4617	34	deficient	deficient	JJ
cord-006229-7yoilsho	4617	35	mice	mouse	NNS
cord-006229-7yoilsho	4617	36	.	.	.
cord-006229-7yoilsho	4618	1	Paw	paw	NN
cord-006229-7yoilsho	4618	2	inflammation	inflammation	NN
cord-006229-7yoilsho	4618	3	and	and	CC
cord-006229-7yoilsho	4618	4	peripheral	peripheral	JJ
cord-006229-7yoilsho	4618	5	nerve	nerve	NN
cord-006229-7yoilsho	4618	6	injury	injury	NN
cord-006229-7yoilsho	4618	7	led	lead	VBN
cord-006229-7yoilsho	4618	8	to	to	IN
cord-006229-7yoilsho	4618	9	upregulation	upregulation	NN
cord-006229-7yoilsho	4618	10	of	of	IN
cord-006229-7yoilsho	4618	11	CSE	CSE	NNP
cord-006229-7yoilsho	4618	12	expression	expression	NN
cord-006229-7yoilsho	4618	13	in	in	IN
cord-006229-7yoilsho	4618	14	dorsal	dorsal	JJ
cord-006229-7yoilsho	4618	15	root	root	NN
cord-006229-7yoilsho	4618	16	ganglia	ganglion	NNS
cord-006229-7yoilsho	4618	17	.	.	.
cord-006229-7yoilsho	4619	1	However	however	RB
cord-006229-7yoilsho	4619	2	,	,	,
cord-006229-7yoilsho	4619	3	conditional	conditional	JJ
cord-006229-7yoilsho	4619	4	knockout	knockout	NN
cord-006229-7yoilsho	4619	5	mice	mouse	NNS
cord-006229-7yoilsho	4619	6	lacking	lack	VBG
cord-006229-7yoilsho	4619	7	CSE	CSE	NNP
cord-006229-7yoilsho	4619	8	in	in	IN
cord-006229-7yoilsho	4619	9	sensory	sensory	JJ
cord-006229-7yoilsho	4619	10	neurons	neuron	NNS
cord-006229-7yoilsho	4619	11	as	as	RB
cord-006229-7yoilsho	4619	12	well	well	RB
cord-006229-7yoilsho	4619	13	as	as	IN
cord-006229-7yoilsho	4619	14	global	global	JJ
cord-006229-7yoilsho	4619	15	CSE	CSE	NNP
cord-006229-7yoilsho	4619	16	knockout	knockout	NN
cord-006229-7yoilsho	4619	17	mice	mouse	NNS
cord-006229-7yoilsho	4619	18	demonstrated	demonstrate	VBD
cord-006229-7yoilsho	4619	19	normal	normal	JJ
cord-006229-7yoilsho	4619	20	pain	pain	NN
cord-006229-7yoilsho	4619	21	behaviors	behavior	NNS
cord-006229-7yoilsho	4619	22	in	in	IN
cord-006229-7yoilsho	4619	23	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	4619	24	and	and	CC
cord-006229-7yoilsho	4619	25	neuropathic	neuropathic	JJ
cord-006229-7yoilsho	4619	26	pain	pain	NN
cord-006229-7yoilsho	4619	27	models	model	NNS
cord-006229-7yoilsho	4619	28	as	as	IN
cord-006229-7yoilsho	4619	29	compared	compare	VBN
cord-006229-7yoilsho	4619	30	to	to	IN
cord-006229-7yoilsho	4619	31	WT	WT	NNP
cord-006229-7yoilsho	4619	32	littermates	littermate	NNS
cord-006229-7yoilsho	4619	33	.	.	.
cord-006229-7yoilsho	4620	1	Thus	thus	RB
cord-006229-7yoilsho	4620	2	,	,	,
cord-006229-7yoilsho	4620	3	our	-PRON-	PRP$
cord-006229-7yoilsho	4620	4	results	result	NNS
cord-006229-7yoilsho	4620	5	suggest	suggest	VBP
cord-006229-7yoilsho	4620	6	that	that	IN
cord-006229-7yoilsho	4620	7	CSE	CSE	NNP
cord-006229-7yoilsho	4620	8	is	be	VBZ
cord-006229-7yoilsho	4620	9	not	not	RB
cord-006229-7yoilsho	4620	10	critically	critically	RB
cord-006229-7yoilsho	4620	11	involved	involve	VBN
cord-006229-7yoilsho	4620	12	in	in	IN
cord-006229-7yoilsho	4620	13	chronic	chronic	JJ
cord-006229-7yoilsho	4620	14	pain	pain	NN
cord-006229-7yoilsho	4620	15	signaling	signal	VBG
cord-006229-7yoilsho	4620	16	in	in	IN
cord-006229-7yoilsho	4620	17	mice	mouse	NNS
cord-006229-7yoilsho	4620	18	and	and	CC
cord-006229-7yoilsho	4620	19	that	that	IN
cord-006229-7yoilsho	4620	20	sources	source	NNS
cord-006229-7yoilsho	4620	21	different	different	JJ
cord-006229-7yoilsho	4620	22	from	from	IN
cord-006229-7yoilsho	4620	23	CSE	CSE	NNP
cord-006229-7yoilsho	4620	24	mediate	mediate	VBP
cord-006229-7yoilsho	4620	25	the	the	DT
cord-006229-7yoilsho	4620	26	pain	pain	NN
cord-006229-7yoilsho	4620	27	relevant	relevant	JJ
cord-006229-7yoilsho	4620	28	effects	effect	NNS
cord-006229-7yoilsho	4620	29	of	of	IN
cord-006229-7yoilsho	4620	30	H	h	NN
cord-006229-7yoilsho	4620	31	2	2	CD
cord-006229-7yoilsho	4620	32	S.	S.	NNP
cord-006229-7yoilsho	4621	1	This	this	DT
cord-006229-7yoilsho	4621	2	work	work	NN
cord-006229-7yoilsho	4621	3	was	be	VBD
cord-006229-7yoilsho	4621	4	supported	support	VBN
cord-006229-7yoilsho	4621	5	by	by	IN
cord-006229-7yoilsho	4621	6	the	the	DT
cord-006229-7yoilsho	4621	7	Deutsche	Deutsche	NNP
cord-006229-7yoilsho	4621	8	Forschungsgemeinschaft	Forschungsgemeinschaft	NNP
cord-006229-7yoilsho	4621	9	(	(	-LRB-
cord-006229-7yoilsho	4621	10	SFB815-A14	SFB815-A14	NNP
cord-006229-7yoilsho	4621	11	)	)	-RRB-
cord-006229-7yoilsho	4621	12	and	and	CC
cord-006229-7yoilsho	4621	13	in	in	IN
cord-006229-7yoilsho	4621	14	part	part	NN
cord-006229-7yoilsho	4621	15	by	by	IN
cord-006229-7yoilsho	4621	16	LOEWE	LOEWE	NNP
cord-006229-7yoilsho	4621	17	-	-	HYPH
cord-006229-7yoilsho	4621	18	Schwerpunkt	Schwerpunkt	NNP
cord-006229-7yoilsho	4621	19	"	"	``
cord-006229-7yoilsho	4621	20	Anwendungsorientierte	Anwendungsorientierte	NNP
cord-006229-7yoilsho	4621	21	Arzneimittelforschung	Arzneimittelforschung	NNP
cord-006229-7yoilsho	4621	22	"	"	''
cord-006229-7yoilsho	4621	23	.	.	.
cord-006229-7yoilsho	4622	1	Heinrich	Heinrich	NNP
cord-006229-7yoilsho	4622	2	-	-	HYPH
cord-006229-7yoilsho	4622	3	Heine	Heine	NNP
cord-006229-7yoilsho	4622	4	-	-	HYPH
cord-006229-7yoilsho	4622	5	Universität	Universität	NNP
cord-006229-7yoilsho	4622	6	,	,	,
cord-006229-7yoilsho	4622	7	Institut	Institut	NNP
cord-006229-7yoilsho	4622	8	für	für	IN
cord-006229-7yoilsho	4622	9	Toxikologie	Toxikologie	NNP
cord-006229-7yoilsho	4622	10	,	,	,
cord-006229-7yoilsho	4622	11	Düsseldorf	Düsseldorf	NNP
cord-006229-7yoilsho	4622	12	,	,	,
cord-006229-7yoilsho	4622	13	Germany	Germany	NNP
cord-006229-7yoilsho	4622	14	2	2	CD
cord-006229-7yoilsho	4622	15	Heinrich	Heinrich	NNP
cord-006229-7yoilsho	4622	16	-	-	HYPH
cord-006229-7yoilsho	4622	17	Heine	Heine	NNP
cord-006229-7yoilsho	4622	18	-	-	HYPH
cord-006229-7yoilsho	4622	19	Universität	Universität	NNP
cord-006229-7yoilsho	4622	20	,	,	,
cord-006229-7yoilsho	4622	21	Urologie	Urologie	NNP
cord-006229-7yoilsho	4622	22	,	,	,
cord-006229-7yoilsho	4622	23	Düsseldorf	Düsseldorf	NNP
cord-006229-7yoilsho	4622	24	,	,	,
cord-006229-7yoilsho	4623	1	Germany	Germany	NNP
cord-006229-7yoilsho	4623	2	Background	Background	NNP
cord-006229-7yoilsho	4623	3	:	:	:
cord-006229-7yoilsho	4624	1	Cisplatin	cisplatin	NN
cord-006229-7yoilsho	4624	2	(	(	-LRB-
cord-006229-7yoilsho	4624	3	CisPt	CisPt	NNP
cord-006229-7yoilsho	4624	4	)	)	-RRB-
cord-006229-7yoilsho	4624	5	is	be	VBZ
cord-006229-7yoilsho	4624	6	frequently	frequently	RB
cord-006229-7yoilsho	4624	7	used	use	VBN
cord-006229-7yoilsho	4624	8	in	in	IN
cord-006229-7yoilsho	4624	9	the	the	DT
cord-006229-7yoilsho	4624	10	therapy	therapy	NN
cord-006229-7yoilsho	4624	11	of	of	IN
cord-006229-7yoilsho	4624	12	advanced	advanced	JJ
cord-006229-7yoilsho	4624	13	stage	stage	NN
cord-006229-7yoilsho	4624	14	urothelial	urothelial	JJ
cord-006229-7yoilsho	4624	15	cell	cell	NN
cord-006229-7yoilsho	4624	16	carcinoma	carcinoma	NN
cord-006229-7yoilsho	4624	17	(	(	-LRB-
cord-006229-7yoilsho	4624	18	UCC	UCC	NNP
cord-006229-7yoilsho	4624	19	)	)	-RRB-
cord-006229-7yoilsho	4624	20	.	.	.
cord-006229-7yoilsho	4625	1	Yet	yet	RB
cord-006229-7yoilsho	4625	2	,	,	,
cord-006229-7yoilsho	4625	3	inherent	inherent	JJ
cord-006229-7yoilsho	4625	4	and	and	CC
cord-006229-7yoilsho	4625	5	acquired	acquire	VBN
cord-006229-7yoilsho	4625	6	drug	drug	NN
cord-006229-7yoilsho	4625	7	resistance	resistance	NN
cord-006229-7yoilsho	4625	8	limits	limit	VBZ
cord-006229-7yoilsho	4625	9	the	the	DT
cord-006229-7yoilsho	4625	10	clinical	clinical	JJ
cord-006229-7yoilsho	4625	11	use	use	NN
cord-006229-7yoilsho	4625	12	of	of	IN
cord-006229-7yoilsho	4625	13	CisPt	CisPt	NNP
cord-006229-7yoilsho	4625	14	.	.	.
cord-006229-7yoilsho	4626	1	Here	here	RB
cord-006229-7yoilsho	4626	2	,	,	,
cord-006229-7yoilsho	4626	3	we	-PRON-	PRP
cord-006229-7yoilsho	4626	4	comparatively	comparatively	RB
cord-006229-7yoilsho	4626	5	investigated	investigate	VBD
cord-006229-7yoilsho	4626	6	the	the	DT
cord-006229-7yoilsho	4626	7	response	response	NN
cord-006229-7yoilsho	4626	8	of	of	IN
cord-006229-7yoilsho	4626	9	epithelial	epithelial	NN
cord-006229-7yoilsho	4626	10	-	-	HYPH
cord-006229-7yoilsho	4626	11	like	like	JJ
cord-006229-7yoilsho	4626	12	(	(	-LRB-
cord-006229-7yoilsho	4626	13	RT-112	rt-112	NN
cord-006229-7yoilsho	4626	14	)	)	-RRB-
cord-006229-7yoilsho	4626	15	and	and	CC
cord-006229-7yoilsho	4626	16	mesenchymal	mesenchymal	JJ
cord-006229-7yoilsho	4626	17	-	-	:
cord-006229-7yoilsho	4626	18	like	like	JJ
cord-006229-7yoilsho	4626	19	(	(	-LRB-
cord-006229-7yoilsho	4626	20	J-82	J-82	NNP
cord-006229-7yoilsho	4626	21	)	)	-RRB-
cord-006229-7yoilsho	4626	22	UC	UC	NNP
cord-006229-7yoilsho	4626	23	cells	cell	NNS
cord-006229-7yoilsho	4626	24	following	follow	VBG
cord-006229-7yoilsho	4626	25	CisPt	CisPt	NNP
cord-006229-7yoilsho	4626	26	treatment	treatment	NN
cord-006229-7yoilsho	4626	27	.	.	.
cord-006229-7yoilsho	4627	1	Methods	method	NNS
cord-006229-7yoilsho	4627	2	:	:	:
cord-006229-7yoilsho	4627	3	Upon	upon	IN
cord-006229-7yoilsho	4627	4	selection	selection	NN
cord-006229-7yoilsho	4627	5	with	with	IN
cord-006229-7yoilsho	4627	6	equitoxic	equitoxic	JJ
cord-006229-7yoilsho	4627	7	doses	dose	NNS
cord-006229-7yoilsho	4627	8	of	of	IN
cord-006229-7yoilsho	4627	9	CisPt	CisPt	NNP
cord-006229-7yoilsho	4627	10	for	for	IN
cord-006229-7yoilsho	4627	11	months	month	NNS
cord-006229-7yoilsho	4627	12	,	,	,
cord-006229-7yoilsho	4627	13	we	-PRON-	PRP
cord-006229-7yoilsho	4627	14	obtained	obtain	VBD
cord-006229-7yoilsho	4627	15	CisPt	CisPt	NNP
cord-006229-7yoilsho	4627	16	resistant	resistant	JJ
cord-006229-7yoilsho	4627	17	variants	variant	NNS
cord-006229-7yoilsho	4627	18	(	(	-LRB-
cord-006229-7yoilsho	4627	19	RT-112	rt-112	NN
cord-006229-7yoilsho	4627	20	R	r	NN
cord-006229-7yoilsho	4627	21	,	,	,
cord-006229-7yoilsho	4627	22	J-82	J-82	NNP
cord-006229-7yoilsho	4627	23	R	R	NNP
cord-006229-7yoilsho	4627	24	)	)	-RRB-
cord-006229-7yoilsho	4627	25	.	.	.
cord-006229-7yoilsho	4628	1	Cell	cell	NN
cord-006229-7yoilsho	4628	2	viability	viability	NN
cord-006229-7yoilsho	4628	3	was	be	VBD
cord-006229-7yoilsho	4628	4	measured	measure	VBN
cord-006229-7yoilsho	4628	5	using	use	VBG
cord-006229-7yoilsho	4628	6	the	the	DT
cord-006229-7yoilsho	4628	7	Alamar	Alamar	NNP
cord-006229-7yoilsho	4628	8	Blue	Blue	NNP
cord-006229-7yoilsho	4628	9	Assay	Assay	NNP
cord-006229-7yoilsho	4628	10	.	.	.
cord-006229-7yoilsho	4629	1	Cell	cell	NN
cord-006229-7yoilsho	4629	2	cycle	cycle	NN
cord-006229-7yoilsho	4629	3	distribution	distribution	NN
cord-006229-7yoilsho	4629	4	was	be	VBD
cord-006229-7yoilsho	4629	5	analysed	analyse	VBN
cord-006229-7yoilsho	4629	6	by	by	IN
cord-006229-7yoilsho	4629	7	flow	flow	NN
cord-006229-7yoilsho	4629	8	cytometry	cytometry	NN
cord-006229-7yoilsho	4629	9	.	.	.
cord-006229-7yoilsho	4630	1	Immunocytochemistry	Immunocytochemistry	NNP
cord-006229-7yoilsho	4630	2	was	be	VBD
cord-006229-7yoilsho	4630	3	used	use	VBN
cord-006229-7yoilsho	4630	4	to	to	TO
cord-006229-7yoilsho	4630	5	quantify	quantify	VB
cord-006229-7yoilsho	4630	6	the	the	DT
cord-006229-7yoilsho	4630	7	number	number	NN
cord-006229-7yoilsho	4630	8	of	of	IN
cord-006229-7yoilsho	4630	9	nuclear	nuclear	JJ
cord-006229-7yoilsho	4630	10	γH2AX	γH2AX	NNP
cord-006229-7yoilsho	4630	11	and	and	CC
cord-006229-7yoilsho	4630	12	53BP1	53bp1	CD
cord-006229-7yoilsho	4630	13	foci	foci	NN
cord-006229-7yoilsho	4630	14	representing	represent	VBG
cord-006229-7yoilsho	4630	15	DNA	dna	NN
cord-006229-7yoilsho	4630	16	double	double	JJ
cord-006229-7yoilsho	4630	17	strand	strand	NN
cord-006229-7yoilsho	4630	18	breaks	break	NNS
cord-006229-7yoilsho	4630	19	(	(	-LRB-
cord-006229-7yoilsho	4630	20	DSBs	DSBs	NNP
cord-006229-7yoilsho	4630	21	)	)	-RRB-
cord-006229-7yoilsho	4630	22	,	,	,
cord-006229-7yoilsho	4630	23	while	while	IN
cord-006229-7yoilsho	4630	24	Western	western	JJ
cord-006229-7yoilsho	4630	25	blot	blot	NN
cord-006229-7yoilsho	4630	26	was	be	VBD
cord-006229-7yoilsho	4630	27	used	use	VBN
cord-006229-7yoilsho	4630	28	to	to	TO
cord-006229-7yoilsho	4630	29	unravel	unravel	VB
cord-006229-7yoilsho	4630	30	the	the	DT
cord-006229-7yoilsho	4630	31	role	role	NN
cord-006229-7yoilsho	4630	32	of	of	IN
cord-006229-7yoilsho	4630	33	DNA	DNA	NNP
cord-006229-7yoilsho	4630	34	Damage	Damage	NNP
cord-006229-7yoilsho	4630	35	Response	response	NN
cord-006229-7yoilsho	4630	36	(	(	-LRB-
cord-006229-7yoilsho	4630	37	DDR	DDR	NNP
cord-006229-7yoilsho	4630	38	)	)	-RRB-
cord-006229-7yoilsho	4630	39	to	to	IN
cord-006229-7yoilsho	4630	40	acquired	acquire	VBN
cord-006229-7yoilsho	4630	41	CisPt	CisPt	NNP
cord-006229-7yoilsho	4630	42	resistance	resistance	NN
cord-006229-7yoilsho	4630	43	.	.	.
cord-006229-7yoilsho	4631	1	QRT	QRT	NNP
cord-006229-7yoilsho	4631	2	-	-	HYPH
cord-006229-7yoilsho	4631	3	PCR	PCR	NNP
cord-006229-7yoilsho	4631	4	was	be	VBD
cord-006229-7yoilsho	4631	5	performed	perform	VBN
cord-006229-7yoilsho	4631	6	to	to	TO
cord-006229-7yoilsho	4631	7	analyse	analyse	VB
cord-006229-7yoilsho	4631	8	the	the	DT
cord-006229-7yoilsho	4631	9	mRNA	mRNA	NNP
cord-006229-7yoilsho	4631	10	expression	expression	NN
cord-006229-7yoilsho	4631	11	of	of	IN
cord-006229-7yoilsho	4631	12	genes	gene	NNS
cord-006229-7yoilsho	4631	13	associated	associate	VBN
cord-006229-7yoilsho	4631	14	with	with	IN
cord-006229-7yoilsho	4631	15	CisPt	CisPt	NNP
cord-006229-7yoilsho	4631	16	resistance	resistance	NN
cord-006229-7yoilsho	4631	17	.	.	.
cord-006229-7yoilsho	4632	1	J-82	J-82	NNP
cord-006229-7yoilsho	4632	2	and	and	CC
cord-006229-7yoilsho	4632	3	J-82	J-82	NNP
cord-006229-7yoilsho	4632	4	R	r	NN
cord-006229-7yoilsho	4632	5	cells	cell	NNS
cord-006229-7yoilsho	4632	6	were	be	VBD
cord-006229-7yoilsho	4632	7	treated	treat	VBN
cord-006229-7yoilsho	4632	8	with	with	IN
cord-006229-7yoilsho	4632	9	different	different	JJ
cord-006229-7yoilsho	4632	10	concentrations	concentration	NNS
cord-006229-7yoilsho	4632	11	of	of	IN
cord-006229-7yoilsho	4632	12	lovastatin	lovastatin	NN
cord-006229-7yoilsho	4632	13	and	and	CC
cord-006229-7yoilsho	4632	14	selected	select	VBN
cord-006229-7yoilsho	4632	15	DDR	DDR	NNP
cord-006229-7yoilsho	4632	16	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	4632	17	to	to	TO
cord-006229-7yoilsho	4632	18	elucidate	elucidate	VB
cord-006229-7yoilsho	4632	19	their	-PRON-	PRP$
cord-006229-7yoilsho	4632	20	influence	influence	NN
cord-006229-7yoilsho	4632	21	on	on	IN
cord-006229-7yoilsho	4632	22	cell	cell	NN
cord-006229-7yoilsho	4632	23	viability	viability	NN
cord-006229-7yoilsho	4632	24	.	.	.
cord-006229-7yoilsho	4633	1	Results	result	NNS
cord-006229-7yoilsho	4633	2	:	:	:
cord-006229-7yoilsho	4634	1	Untreated	untreated	JJ
cord-006229-7yoilsho	4634	2	RT-112	rt-112	NN
cord-006229-7yoilsho	4634	3	cells	cell	NNS
cord-006229-7yoilsho	4634	4	showed	show	VBD
cord-006229-7yoilsho	4634	5	an	an	DT
cord-006229-7yoilsho	4634	6	about	about	RB
cord-006229-7yoilsho	4634	7	2	2	CD
cord-006229-7yoilsho	4634	8	-	-	HYPH
cord-006229-7yoilsho	4634	9	3-fold	3-fold	CD
cord-006229-7yoilsho	4634	10	higher	high	JJR
cord-006229-7yoilsho	4634	11	resistance	resistance	NN
cord-006229-7yoilsho	4634	12	to	to	IN
cord-006229-7yoilsho	4634	13	CisPt	CisPt	NNP
cord-006229-7yoilsho	4634	14	than	than	IN
cord-006229-7yoilsho	4634	15	J-82	J-82	NNP
cord-006229-7yoilsho	4634	16	cells	cell	NNS
cord-006229-7yoilsho	4634	17	.	.	.
cord-006229-7yoilsho	4635	1	Both	both	DT
cord-006229-7yoilsho	4635	2	cell	cell	NN
cord-006229-7yoilsho	4635	3	lines	line	NNS
cord-006229-7yoilsho	4635	4	differed	differ	VBD
cord-006229-7yoilsho	4635	5	in	in	IN
cord-006229-7yoilsho	4635	6	the	the	DT
cord-006229-7yoilsho	4635	7	expression	expression	NN
cord-006229-7yoilsho	4635	8	pattern	pattern	NN
cord-006229-7yoilsho	4635	9	of	of	IN
cord-006229-7yoilsho	4635	10	genes	gene	NNS
cord-006229-7yoilsho	4635	11	that	that	WDT
cord-006229-7yoilsho	4635	12	are	be	VBP
cord-006229-7yoilsho	4635	13	associated	associate	VBN
cord-006229-7yoilsho	4635	14	with	with	IN
cord-006229-7yoilsho	4635	15	CisPt	CisPt	NNP
cord-006229-7yoilsho	4635	16	resistance	resistance	NN
cord-006229-7yoilsho	4635	17	.	.	.
cord-006229-7yoilsho	4636	1	RT-112	rt-112	NN
cord-006229-7yoilsho	4636	2	R	r	NN
cord-006229-7yoilsho	4636	3	and	and	CC
cord-006229-7yoilsho	4636	4	J-82	J-82	NNP
cord-006229-7yoilsho	4637	1	R	R	NNP
cord-006229-7yoilsho	4637	2	revealed	reveal	VBD
cord-006229-7yoilsho	4637	3	a	a	DT
cord-006229-7yoilsho	4637	4	2	2	CD
cord-006229-7yoilsho	4637	5	-	-	HYPH
cord-006229-7yoilsho	4637	6	3-fold	3-fold	CD
cord-006229-7yoilsho	4637	7	increased	increase	VBN
cord-006229-7yoilsho	4637	8	CisPt	cispt	JJ
cord-006229-7yoilsho	4637	9	resistance	resistance	NN
cord-006229-7yoilsho	4637	10	as	as	IN
cord-006229-7yoilsho	4637	11	compared	compare	VBN
cord-006229-7yoilsho	4637	12	to	to	IN
cord-006229-7yoilsho	4637	13	the	the	DT
cord-006229-7yoilsho	4637	14	parental	parental	JJ
cord-006229-7yoilsho	4637	15	cells	cell	NNS
cord-006229-7yoilsho	4637	16	.	.	.
cord-006229-7yoilsho	4638	1	During	during	IN
cord-006229-7yoilsho	4638	2	the	the	DT
cord-006229-7yoilsho	4638	3	selection	selection	NN
cord-006229-7yoilsho	4638	4	procedure	procedure	NN
cord-006229-7yoilsho	4638	5	,	,	,
cord-006229-7yoilsho	4638	6	we	-PRON-	PRP
cord-006229-7yoilsho	4638	7	observed	observe	VBD
cord-006229-7yoilsho	4638	8	that	that	IN
cord-006229-7yoilsho	4638	9	acquired	acquire	VBD
cord-006229-7yoilsho	4638	10	CisPt	CisPt	NNP
cord-006229-7yoilsho	4638	11	resistance	resistance	NN
cord-006229-7yoilsho	4638	12	goes	go	VBZ
cord-006229-7yoilsho	4638	13	along	along	RB
cord-006229-7yoilsho	4638	14	with	with	IN
cord-006229-7yoilsho	4638	15	morphological	morphological	JJ
cord-006229-7yoilsho	4638	16	alterations	alteration	NNS
cord-006229-7yoilsho	4638	17	that	that	WDT
cord-006229-7yoilsho	4638	18	resemble	resemble	VBP
cord-006229-7yoilsho	4638	19	epithelial	epithelial	JJ
cord-006229-7yoilsho	4638	20	mesenchymal	mesenchymal	JJ
cord-006229-7yoilsho	4638	21	transition	transition	NN
cord-006229-7yoilsho	4638	22	(	(	-LRB-
cord-006229-7yoilsho	4638	23	EMT	EMT	NNP
cord-006229-7yoilsho	4638	24	)	)	-RRB-
cord-006229-7yoilsho	4638	25	.	.	.
cord-006229-7yoilsho	4639	1	Cell	cell	NN
cord-006229-7yoilsho	4639	2	cycle	cycle	NN
cord-006229-7yoilsho	4639	3	analysis	analysis	NN
cord-006229-7yoilsho	4639	4	of	of	IN
cord-006229-7yoilsho	4639	5	RT-112	rt-112	NN
cord-006229-7yoilsho	4639	6	R	r	NN
cord-006229-7yoilsho	4639	7	cells	cell	NNS
cord-006229-7yoilsho	4639	8	disclosed	disclose	VBD
cord-006229-7yoilsho	4639	9	a	a	DT
cord-006229-7yoilsho	4639	10	reduced	reduce	VBN
cord-006229-7yoilsho	4639	11	apoptosis	apoptosis	NN
cord-006229-7yoilsho	4639	12	and	and	CC
cord-006229-7yoilsho	4639	13	enhanced	enhance	VBN
cord-006229-7yoilsho	4639	14	G2	G2	NNP
cord-006229-7yoilsho	4639	15	/	/	SYM
cord-006229-7yoilsho	4639	16	M	M	NNP
cord-006229-7yoilsho	4639	17	arrest	arrest	NN
cord-006229-7yoilsho	4639	18	following	follow	VBG
cord-006229-7yoilsho	4639	19	CisPt	CisPt	NNP
cord-006229-7yoilsho	4639	20	exposure	exposure	NN
cord-006229-7yoilsho	4639	21	as	as	IN
cord-006229-7yoilsho	4639	22	compared	compare	VBN
cord-006229-7yoilsho	4639	23	to	to	IN
cord-006229-7yoilsho	4639	24	RT-112	rt-112	NN
cord-006229-7yoilsho	4639	25	wild	wild	JJ
cord-006229-7yoilsho	4639	26	-	-	HYPH
cord-006229-7yoilsho	4639	27	type	type	NN
cord-006229-7yoilsho	4639	28	cells	cell	NNS
cord-006229-7yoilsho	4639	29	.	.	.
cord-006229-7yoilsho	4640	1	By	by	IN
cord-006229-7yoilsho	4640	2	contrast	contrast	NN
cord-006229-7yoilsho	4640	3	,	,	,
cord-006229-7yoilsho	4640	4	induction	induction	NN
cord-006229-7yoilsho	4640	5	of	of	IN
cord-006229-7yoilsho	4640	6	cell	cell	NN
cord-006229-7yoilsho	4640	7	death	death	NN
cord-006229-7yoilsho	4640	8	was	be	VBD
cord-006229-7yoilsho	4640	9	similar	similar	JJ
cord-006229-7yoilsho	4640	10	in	in	IN
cord-006229-7yoilsho	4640	11	J-82	J-82	NNP
cord-006229-7yoilsho	4640	12	and	and	CC
cord-006229-7yoilsho	4640	13	J-82	J-82	NNP
cord-006229-7yoilsho	4640	14	R	r	NN
cord-006229-7yoilsho	4640	15	cells	cell	NNS
cord-006229-7yoilsho	4640	16	.	.	.
cord-006229-7yoilsho	4641	1	Notably	notably	RB
cord-006229-7yoilsho	4641	2	,	,	,
cord-006229-7yoilsho	4641	3	J-82	J-82	NNP
cord-006229-7yoilsho	4641	4	R	r	NN
cord-006229-7yoilsho	4641	5	cells	cell	NNS
cord-006229-7yoilsho	4641	6	showed	show	VBD
cord-006229-7yoilsho	4641	7	a	a	DT
cord-006229-7yoilsho	4641	8	reduced	reduce	VBN
cord-006229-7yoilsho	4641	9	formation	formation	NN
cord-006229-7yoilsho	4641	10	of	of	IN
cord-006229-7yoilsho	4641	11	CisPt	CisPt	NNP
cord-006229-7yoilsho	4641	12	-	-	HYPH
cord-006229-7yoilsho	4641	13	induced	induce	VBN
cord-006229-7yoilsho	4641	14	DSBs	dsb	NNS
cord-006229-7yoilsho	4641	15	.	.	.
cord-006229-7yoilsho	4642	1	Correspondingly	correspondingly	RB
cord-006229-7yoilsho	4642	2	,	,	,
cord-006229-7yoilsho	4642	3	the	the	DT
cord-006229-7yoilsho	4642	4	related	related	JJ
cord-006229-7yoilsho	4642	5	DDR	DDR	NNP
cord-006229-7yoilsho	4642	6	was	be	VBD
cord-006229-7yoilsho	4642	7	diminished	diminish	VBN
cord-006229-7yoilsho	4642	8	in	in	IN
cord-006229-7yoilsho	4642	9	J-82	J-82	NNP
cord-006229-7yoilsho	4642	10	R	R	NNP
cord-006229-7yoilsho	4642	11	as	as	IN
cord-006229-7yoilsho	4642	12	compared	compare	VBN
cord-006229-7yoilsho	4642	13	to	to	IN
cord-006229-7yoilsho	4642	14	their	-PRON-	PRP$
cord-006229-7yoilsho	4642	15	parental	parental	JJ
cord-006229-7yoilsho	4642	16	cells	cell	NNS
cord-006229-7yoilsho	4642	17	.	.	.
cord-006229-7yoilsho	4643	1	This	this	DT
cord-006229-7yoilsho	4643	2	was	be	VBD
cord-006229-7yoilsho	4643	3	not	not	RB
cord-006229-7yoilsho	4643	4	found	find	VBN
cord-006229-7yoilsho	4643	5	when	when	WRB
cord-006229-7yoilsho	4643	6	DDR	DDR	NNP
cord-006229-7yoilsho	4643	7	was	be	VBD
cord-006229-7yoilsho	4643	8	comparatively	comparatively	RB
cord-006229-7yoilsho	4643	9	analysed	analyse	VBN
cord-006229-7yoilsho	4643	10	between	between	IN
cord-006229-7yoilsho	4643	11	RT-112	rt-112	NN
cord-006229-7yoilsho	4643	12	R	r	NN
cord-006229-7yoilsho	4643	13	and	and	CC
cord-006229-7yoilsho	4643	14	RT-112	rt-112	NN
cord-006229-7yoilsho	4643	15	cells	cell	NNS
cord-006229-7yoilsho	4643	16	.	.	.
cord-006229-7yoilsho	4644	1	Data	datum	NNS
cord-006229-7yoilsho	4644	2	obtained	obtain	VBN
cord-006229-7yoilsho	4644	3	from	from	IN
cord-006229-7yoilsho	4644	4	qRT	qRT	NNP
cord-006229-7yoilsho	4644	5	-	-	HYPH
cord-006229-7yoilsho	4644	6	PCR	PCR	NNP
cord-006229-7yoilsho	4644	7	analysis	analysis	NN
cord-006229-7yoilsho	4644	8	indicate	indicate	VBP
cord-006229-7yoilsho	4644	9	that	that	IN
cord-006229-7yoilsho	4644	10	different	different	JJ
cord-006229-7yoilsho	4644	11	mechanisms	mechanism	NNS
cord-006229-7yoilsho	4644	12	contribute	contribute	VBP
cord-006229-7yoilsho	4644	13	to	to	IN
cord-006229-7yoilsho	4644	14	acquired	acquire	VBN
cord-006229-7yoilsho	4644	15	drug	drug	NN
cord-006229-7yoilsho	4644	16	resistance	resistance	NN
cord-006229-7yoilsho	4644	17	of	of	IN
cord-006229-7yoilsho	4644	18	J-82	J-82	NNP
cord-006229-7yoilsho	4644	19	R	R	NNP
cord-006229-7yoilsho	4644	20	and	and	CC
cord-006229-7yoilsho	4644	21	RT-112	rt-112	NN
cord-006229-7yoilsho	4644	22	R	r	NN
cord-006229-7yoilsho	4644	23	.	.	.
cord-006229-7yoilsho	4645	1	Unexpectedly	unexpectedly	RB
cord-006229-7yoilsho	4645	2	,	,	,
cord-006229-7yoilsho	4645	3	J-82	J-82	NNP
cord-006229-7yoilsho	4645	4	R	R	NNP
cord-006229-7yoilsho	4645	5	and	and	CC
cord-006229-7yoilsho	4645	6	RT-112	rt-112	NN
cord-006229-7yoilsho	4645	7	R	r	NN
cord-006229-7yoilsho	4645	8	shared	share	VBD
cord-006229-7yoilsho	4645	9	the	the	DT
cord-006229-7yoilsho	4645	10	upregulation	upregulation	NN
cord-006229-7yoilsho	4645	11	of	of	IN
cord-006229-7yoilsho	4645	12	XAF-1	XAF-1	NNP
cord-006229-7yoilsho	4645	13	.	.	.
cord-006229-7yoilsho	4646	1	Treatment	treatment	NN
cord-006229-7yoilsho	4646	2	of	of	IN
cord-006229-7yoilsho	4646	3	J-82	J-82	NNP
cord-006229-7yoilsho	4646	4	R	r	NN
cord-006229-7yoilsho	4646	5	cells	cell	NNS
cord-006229-7yoilsho	4646	6	with	with	IN
cord-006229-7yoilsho	4646	7	statins	statin	NNS
cord-006229-7yoilsho	4646	8	and	and	CC
cord-006229-7yoilsho	4646	9	protein	protein	NN
cord-006229-7yoilsho	4646	10	kinase	kinase	NN
cord-006229-7yoilsho	4646	11	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	4646	12	revealed	reveal	VBD
cord-006229-7yoilsho	4646	13	an	an	DT
cord-006229-7yoilsho	4646	14	enhanced	enhance	VBN
cord-006229-7yoilsho	4646	15	sensitivity	sensitivity	NN
cord-006229-7yoilsho	4646	16	to	to	IN
cord-006229-7yoilsho	4646	17	pharmacological	pharmacological	JJ
cord-006229-7yoilsho	4646	18	inhibition	inhibition	NN
cord-006229-7yoilsho	4646	19	of	of	IN
cord-006229-7yoilsho	4646	20	Chk-1	Chk-1	NNP
cord-006229-7yoilsho	4647	1	and	and	CC
cord-006229-7yoilsho	4647	2	,	,	,
cord-006229-7yoilsho	4647	3	moreover	moreover	RB
cord-006229-7yoilsho	4647	4	,	,	,
cord-006229-7yoilsho	4647	5	re	re	NN
cord-006229-7yoilsho	4647	6	-	-	NN
cord-006229-7yoilsho	4647	7	sensitization	sensitization	NN
cord-006229-7yoilsho	4647	8	to	to	IN
cord-006229-7yoilsho	4647	9	CisPt	CisPt	NNP
cord-006229-7yoilsho	4647	10	by	by	IN
cord-006229-7yoilsho	4647	11	Chk-1	Chk-1	NNP
cord-006229-7yoilsho	4647	12	inhibitor	inhibitor	NN
cord-006229-7yoilsho	4647	13	.	.	.
cord-006229-7yoilsho	4648	1	Based	base	VBN
cord-006229-7yoilsho	4648	2	on	on	IN
cord-006229-7yoilsho	4648	3	the	the	DT
cord-006229-7yoilsho	4648	4	data	datum	NNS
cord-006229-7yoilsho	4648	5	we	-PRON-	PRP
cord-006229-7yoilsho	4648	6	suggest	suggest	VBP
cord-006229-7yoilsho	4648	7	that	that	IN
cord-006229-7yoilsho	4648	8	mechanisms	mechanism	NNS
cord-006229-7yoilsho	4648	9	of	of	IN
cord-006229-7yoilsho	4648	10	acquired	acquire	VBN
cord-006229-7yoilsho	4648	11	CisPt	CisPt	NNP
cord-006229-7yoilsho	4648	12	resistance	resistance	NN
cord-006229-7yoilsho	4648	13	of	of	IN
cord-006229-7yoilsho	4648	14	epithelial	epithelial	JJ
cord-006229-7yoilsho	4648	15	and	and	CC
cord-006229-7yoilsho	4648	16	mesenchymal	mesenchymal	JJ
cord-006229-7yoilsho	4648	17	UC	UC	NNP
cord-006229-7yoilsho	4648	18	cell	cell	NN
cord-006229-7yoilsho	4648	19	lines	line	NNS
cord-006229-7yoilsho	4648	20	are	be	VBP
cord-006229-7yoilsho	4648	21	different	different	JJ
cord-006229-7yoilsho	4648	22	with	with	IN
cord-006229-7yoilsho	4648	23	apoptosisrelated	apoptosisrelated	JJ
cord-006229-7yoilsho	4648	24	mechanisms	mechanism	NNS
cord-006229-7yoilsho	4648	25	appear	appear	VBP
cord-006229-7yoilsho	4648	26	to	to	TO
cord-006229-7yoilsho	4648	27	be	be	VB
cord-006229-7yoilsho	4648	28	more	more	RBR
cord-006229-7yoilsho	4648	29	relevant	relevant	JJ
cord-006229-7yoilsho	4648	30	for	for	IN
cord-006229-7yoilsho	4648	31	epithelial	epithelial	JJ
cord-006229-7yoilsho	4648	32	-	-	HYPH
cord-006229-7yoilsho	4648	33	like	like	JJ
cord-006229-7yoilsho	4648	34	RT-112	rt-112	NN
cord-006229-7yoilsho	4648	35	cells	cell	NNS
cord-006229-7yoilsho	4648	36	and	and	CC
cord-006229-7yoilsho	4648	37	DDR	ddr	NN
cord-006229-7yoilsho	4648	38	-	-	HYPH
cord-006229-7yoilsho	4648	39	related	relate	VBN
cord-006229-7yoilsho	4648	40	mechanisms	mechanism	NNS
cord-006229-7yoilsho	4648	41	dominating	dominate	VBG
cord-006229-7yoilsho	4648	42	CisPt	CisPt	VBN
cord-006229-7yoilsho	4648	43	susceptibility	susceptibility	NN
cord-006229-7yoilsho	4648	44	in	in	IN
cord-006229-7yoilsho	4648	45	mesenchymal	mesenchymal	NN
cord-006229-7yoilsho	4648	46	-	-	HYPH
cord-006229-7yoilsho	4648	47	like	like	JJ
cord-006229-7yoilsho	4648	48	J-82	J-82	NNP
cord-006229-7yoilsho	4648	49	cells	cell	NNS
cord-006229-7yoilsho	4648	50	.	.	.
cord-006229-7yoilsho	4649	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	4649	2	,	,	,
cord-006229-7yoilsho	4649	3	our	-PRON-	PRP$
cord-006229-7yoilsho	4649	4	findings	finding	NNS
cord-006229-7yoilsho	4649	5	indicate	indicate	VBP
cord-006229-7yoilsho	4649	6	that	that	IN
cord-006229-7yoilsho	4649	7	Chk-1	Chk-1	NNP
cord-006229-7yoilsho	4649	8	might	may	MD
cord-006229-7yoilsho	4649	9	be	be	VB
cord-006229-7yoilsho	4649	10	an	an	DT
cord-006229-7yoilsho	4649	11	appropriate	appropriate	JJ
cord-006229-7yoilsho	4649	12	target	target	NN
cord-006229-7yoilsho	4649	13	to	to	TO
cord-006229-7yoilsho	4649	14	deal	deal	VB
cord-006229-7yoilsho	4649	15	with	with	IN
cord-006229-7yoilsho	4649	16	acquired	acquire	VBN
cord-006229-7yoilsho	4649	17	CisPt	CisPt	NNP
cord-006229-7yoilsho	4649	18	resistance	resistance	NN
cord-006229-7yoilsho	4649	19	in	in	IN
cord-006229-7yoilsho	4649	20	UCC	UCC	NNP
cord-006229-7yoilsho	4649	21	.	.	.
cord-006229-7yoilsho	4650	1	In	in	IN
cord-006229-7yoilsho	4650	2	many	many	JJ
cord-006229-7yoilsho	4650	3	patients	patient	NNS
cord-006229-7yoilsho	4650	4	,	,	,
cord-006229-7yoilsho	4650	5	gastric	gastric	JJ
cord-006229-7yoilsho	4650	6	cancer	cancer	NN
cord-006229-7yoilsho	4650	7	treatment	treatment	NN
cord-006229-7yoilsho	4650	8	with	with	IN
cord-006229-7yoilsho	4650	9	conventional	conventional	JJ
cord-006229-7yoilsho	4650	10	cytostatic	cytostatic	JJ
cord-006229-7yoilsho	4650	11	agents	agent	NNS
cord-006229-7yoilsho	4650	12	shows	show	VBZ
cord-006229-7yoilsho	4650	13	only	only	RB
cord-006229-7yoilsho	4650	14	limited	limited	JJ
cord-006229-7yoilsho	4650	15	clinical	clinical	JJ
cord-006229-7yoilsho	4650	16	response	response	NN
cord-006229-7yoilsho	4650	17	.	.	.
cord-006229-7yoilsho	4651	1	Novel	novel	JJ
cord-006229-7yoilsho	4651	2	therapeutics	therapeutic	NNS
cord-006229-7yoilsho	4651	3	,	,	,
cord-006229-7yoilsho	4651	4	which	which	WDT
cord-006229-7yoilsho	4651	5	inhibit	inhibit	VBP
cord-006229-7yoilsho	4651	6	RTK	RTK	NNP
cord-006229-7yoilsho	4651	7	signaling	signal	VBG
cord-006229-7yoilsho	4651	8	by	by	IN
cord-006229-7yoilsho	4651	9	targeting	target	VBG
cord-006229-7yoilsho	4651	10	c	c	NN
cord-006229-7yoilsho	4651	11	-	-	HYPH
cord-006229-7yoilsho	4651	12	met	meet	VBN
cord-006229-7yoilsho	4651	13	or	or	CC
cord-006229-7yoilsho	4651	14	HER	her	PRP$
cord-006229-7yoilsho	4651	15	family	family	NN
cord-006229-7yoilsho	4651	16	receptors	receptor	NNS
cord-006229-7yoilsho	4651	17	,	,	,
cord-006229-7yoilsho	4651	18	have	have	VBP
cord-006229-7yoilsho	4651	19	demonstrated	demonstrate	VBN
cord-006229-7yoilsho	4651	20	some	some	DT
cord-006229-7yoilsho	4651	21	efficacy	efficacy	NN
cord-006229-7yoilsho	4651	22	;	;	:
cord-006229-7yoilsho	4651	23	however	however	RB
cord-006229-7yoilsho	4651	24	,	,	,
cord-006229-7yoilsho	4651	25	primary	primary	JJ
cord-006229-7yoilsho	4651	26	resistance	resistance	NN
cord-006229-7yoilsho	4651	27	of	of	IN
cord-006229-7yoilsho	4651	28	gastric	gastric	JJ
cord-006229-7yoilsho	4651	29	cancer	cancer	NN
cord-006229-7yoilsho	4651	30	cells	cell	NNS
cord-006229-7yoilsho	4651	31	against	against	IN
cord-006229-7yoilsho	4651	32	these	these	DT
cord-006229-7yoilsho	4651	33	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	4651	34	is	be	VBZ
cord-006229-7yoilsho	4651	35	still	still	RB
cord-006229-7yoilsho	4651	36	a	a	DT
cord-006229-7yoilsho	4651	37	major	major	JJ
cord-006229-7yoilsho	4651	38	problem	problem	NN
cord-006229-7yoilsho	4651	39	.	.	.
cord-006229-7yoilsho	4652	1	In	in	IN
cord-006229-7yoilsho	4652	2	the	the	DT
cord-006229-7yoilsho	4652	3	present	present	JJ
cord-006229-7yoilsho	4652	4	study	study	NN
cord-006229-7yoilsho	4652	5	we	-PRON-	PRP
cord-006229-7yoilsho	4652	6	investigated	investigate	VBD
cord-006229-7yoilsho	4652	7	the	the	DT
cord-006229-7yoilsho	4652	8	mechanism	mechanism	NN
cord-006229-7yoilsho	4652	9	of	of	IN
cord-006229-7yoilsho	4652	10	heregulin	heregulin	NNP
cord-006229-7yoilsho	4652	11	(	(	-LRB-
cord-006229-7yoilsho	4652	12	HRG)-promoted	hrg)-promote	VBN
cord-006229-7yoilsho	4652	13	survival	survival	NN
cord-006229-7yoilsho	4652	14	of	of	IN
cord-006229-7yoilsho	4652	15	gastric	gastric	JJ
cord-006229-7yoilsho	4652	16	cancer	cancer	NN
cord-006229-7yoilsho	4652	17	cells	cell	NNS
cord-006229-7yoilsho	4652	18	after	after	IN
cord-006229-7yoilsho	4652	19	treatment	treatment	NN
cord-006229-7yoilsho	4652	20	with	with	IN
cord-006229-7yoilsho	4652	21	c	c	NN
cord-006229-7yoilsho	4652	22	-	-	HYPH
cord-006229-7yoilsho	4652	23	met	meet	VBN
cord-006229-7yoilsho	4652	24	inhbitors	inhbitor	NNS
cord-006229-7yoilsho	4652	25	or	or	CC
cord-006229-7yoilsho	4652	26	siRNA	siRNA	NNP
cord-006229-7yoilsho	4652	27	-	-	HYPH
cord-006229-7yoilsho	4652	28	mediated	mediate	VBN
cord-006229-7yoilsho	4652	29	downregulation	downregulation	NN
cord-006229-7yoilsho	4652	30	of	of	IN
cord-006229-7yoilsho	4652	31	c	c	NN
cord-006229-7yoilsho	4652	32	-	-	HYPH
cord-006229-7yoilsho	4652	33	met	meet	VBN
cord-006229-7yoilsho	4652	34	.	.	.
cord-006229-7yoilsho	4653	1	We	-PRON-	PRP
cord-006229-7yoilsho	4653	2	found	find	VBD
cord-006229-7yoilsho	4653	3	that	that	IN
cord-006229-7yoilsho	4653	4	HRG	HRG	NNP
cord-006229-7yoilsho	4653	5	treatment	treatment	NN
cord-006229-7yoilsho	4653	6	of	of	IN
cord-006229-7yoilsho	4653	7	gastric	gastric	JJ
cord-006229-7yoilsho	4653	8	cancer	cancer	NN
cord-006229-7yoilsho	4653	9	cells	cell	NNS
cord-006229-7yoilsho	4653	10	with	with	IN
cord-006229-7yoilsho	4653	11	a	a	DT
cord-006229-7yoilsho	4653	12	c	c	NN
cord-006229-7yoilsho	4653	13	-	-	HYPH
cord-006229-7yoilsho	4653	14	met	meet	VBN
cord-006229-7yoilsho	4653	15	amplification	amplification	NN
cord-006229-7yoilsho	4653	16	partially	partially	RB
cord-006229-7yoilsho	4653	17	rescued	rescue	VBD
cord-006229-7yoilsho	4653	18	the	the	DT
cord-006229-7yoilsho	4653	19	cells	cell	NNS
cord-006229-7yoilsho	4653	20	from	from	IN
cord-006229-7yoilsho	4653	21	the	the	DT
cord-006229-7yoilsho	4653	22	antiproliferative	antiproliferative	JJ
cord-006229-7yoilsho	4653	23	effects	effect	NNS
cord-006229-7yoilsho	4653	24	of	of	IN
cord-006229-7yoilsho	4653	25	pharmacological	pharmacological	JJ
cord-006229-7yoilsho	4653	26	c	c	NN
cord-006229-7yoilsho	4653	27	-	-	HYPH
cord-006229-7yoilsho	4653	28	met	meet	VBN
cord-006229-7yoilsho	4653	29	inhibition	inhibition	NN
cord-006229-7yoilsho	4653	30	or	or	CC
cord-006229-7yoilsho	4653	31	siRNA	sirna	NN
cord-006229-7yoilsho	4653	32	-	-	HYPH
cord-006229-7yoilsho	4653	33	mediated	mediate	VBN
cord-006229-7yoilsho	4653	34	downregulation	downregulation	NN
cord-006229-7yoilsho	4653	35	of	of	IN
cord-006229-7yoilsho	4653	36	c	c	NN
cord-006229-7yoilsho	4653	37	-	-	HYPH
cord-006229-7yoilsho	4653	38	met	meet	VBN
cord-006229-7yoilsho	4653	39	.	.	.
cord-006229-7yoilsho	4654	1	Moreover	moreover	RB
cord-006229-7yoilsho	4654	2	,	,	,
cord-006229-7yoilsho	4654	3	c	c	LS
cord-006229-7yoilsho	4654	4	-	-	HYPH
cord-006229-7yoilsho	4654	5	met	meet	VBN
cord-006229-7yoilsho	4654	6	inhibition	inhibition	NN
cord-006229-7yoilsho	4654	7	or	or	CC
cord-006229-7yoilsho	4654	8	downregulation	downregulation	NN
cord-006229-7yoilsho	4654	9	led	lead	VBD
cord-006229-7yoilsho	4654	10	to	to	IN
cord-006229-7yoilsho	4654	11	an	an	DT
cord-006229-7yoilsho	4654	12	induction	induction	NN
cord-006229-7yoilsho	4654	13	of	of	IN
cord-006229-7yoilsho	4654	14	HER3	HER3	NNP
cord-006229-7yoilsho	4654	15	expression	expression	NN
cord-006229-7yoilsho	4654	16	on	on	IN
cord-006229-7yoilsho	4654	17	mRNA	mRNA	NNP
cord-006229-7yoilsho	4654	18	and	and	CC
cord-006229-7yoilsho	4654	19	protein	protein	NN
cord-006229-7yoilsho	4654	20	level	level	NN
cord-006229-7yoilsho	4654	21	,	,	,
cord-006229-7yoilsho	4654	22	whereas	whereas	IN
cord-006229-7yoilsho	4654	23	other	other	JJ
cord-006229-7yoilsho	4654	24	HER	her	PRP$
cord-006229-7yoilsho	4654	25	family	family	NN
cord-006229-7yoilsho	4654	26	receptors	receptor	NNS
cord-006229-7yoilsho	4654	27	were	be	VBD
cord-006229-7yoilsho	4654	28	unaffected	unaffected	JJ
cord-006229-7yoilsho	4654	29	.	.	.
cord-006229-7yoilsho	4655	1	Downregulation	Downregulation	NNP
cord-006229-7yoilsho	4655	2	of	of	IN
cord-006229-7yoilsho	4655	3	HER3	HER3	NNP
cord-006229-7yoilsho	4655	4	impaired	impair	VBD
cord-006229-7yoilsho	4655	5	the	the	DT
cord-006229-7yoilsho	4655	6	HRG	HRG	NNP
cord-006229-7yoilsho	4655	7	-	-	HYPH
cord-006229-7yoilsho	4655	8	mediated	mediate	VBN
cord-006229-7yoilsho	4655	9	rescue	rescue	NN
cord-006229-7yoilsho	4655	10	of	of	IN
cord-006229-7yoilsho	4655	11	cell	cell	NN
cord-006229-7yoilsho	4655	12	survival	survival	NN
cord-006229-7yoilsho	4655	13	upon	upon	IN
cord-006229-7yoilsho	4655	14	c	c	NN
cord-006229-7yoilsho	4655	15	-	-	HYPH
cord-006229-7yoilsho	4655	16	met	meet	VBN
cord-006229-7yoilsho	4655	17	inhibition	inhibition	NN
cord-006229-7yoilsho	4655	18	.	.	.
cord-006229-7yoilsho	4656	1	In	in	IN
cord-006229-7yoilsho	4656	2	other	other	JJ
cord-006229-7yoilsho	4656	3	tumor	tumor	NN
cord-006229-7yoilsho	4656	4	entities	entity	NNS
cord-006229-7yoilsho	4656	5	the	the	DT
cord-006229-7yoilsho	4656	6	chromatin	chromatin	NN
cord-006229-7yoilsho	4656	7	organizer	organizer	NN
cord-006229-7yoilsho	4656	8	special	special	JJ
cord-006229-7yoilsho	4656	9	AT	at	IN
cord-006229-7yoilsho	4656	10	-	-	HYPH
cord-006229-7yoilsho	4656	11	rich	rich	JJ
cord-006229-7yoilsho	4656	12	sequence	sequence	NN
cord-006229-7yoilsho	4656	13	-	-	HYPH
cord-006229-7yoilsho	4656	14	binding	bind	VBG
cord-006229-7yoilsho	4656	15	protein	protein	NN
cord-006229-7yoilsho	4656	16	1	1	CD
cord-006229-7yoilsho	4656	17	(	(	-LRB-
cord-006229-7yoilsho	4656	18	SATB1	SATB1	NNP
cord-006229-7yoilsho	4656	19	)	)	-RRB-
cord-006229-7yoilsho	4656	20	has	have	VBZ
cord-006229-7yoilsho	4656	21	been	be	VBN
cord-006229-7yoilsho	4656	22	described	describe	VBN
cord-006229-7yoilsho	4656	23	as	as	IN
cord-006229-7yoilsho	4656	24	a	a	DT
cord-006229-7yoilsho	4656	25	regulator	regulator	NN
cord-006229-7yoilsho	4656	26	of	of	IN
cord-006229-7yoilsho	4656	27	HER	her	PRP$
cord-006229-7yoilsho	4656	28	family	family	NN
cord-006229-7yoilsho	4656	29	receptor	receptor	NN
cord-006229-7yoilsho	4656	30	expression	expression	NN
cord-006229-7yoilsho	4656	31	involved	involve	VBN
cord-006229-7yoilsho	4656	32	in	in	IN
cord-006229-7yoilsho	4656	33	adaptive	adaptive	JJ
cord-006229-7yoilsho	4656	34	responses	response	NNS
cord-006229-7yoilsho	4656	35	of	of	IN
cord-006229-7yoilsho	4656	36	tumor	tumor	NN
cord-006229-7yoilsho	4656	37	cells	cell	NNS
cord-006229-7yoilsho	4656	38	.	.	.
cord-006229-7yoilsho	4657	1	Thus	thus	RB
cord-006229-7yoilsho	4657	2	,	,	,
cord-006229-7yoilsho	4657	3	we	-PRON-	PRP
cord-006229-7yoilsho	4657	4	investigated	investigate	VBD
cord-006229-7yoilsho	4657	5	the	the	DT
cord-006229-7yoilsho	4657	6	contribution	contribution	NN
cord-006229-7yoilsho	4657	7	of	of	IN
cord-006229-7yoilsho	4657	8	SATB1	satb1	NN
cord-006229-7yoilsho	4657	9	in	in	IN
cord-006229-7yoilsho	4657	10	the	the	DT
cord-006229-7yoilsho	4657	11	upregulation	upregulation	NN
cord-006229-7yoilsho	4657	12	of	of	IN
cord-006229-7yoilsho	4657	13	HER3	HER3	NNP
cord-006229-7yoilsho	4657	14	after	after	IN
cord-006229-7yoilsho	4657	15	c	c	NNP
cord-006229-7yoilsho	4657	16	-	-	HYPH
cord-006229-7yoilsho	4657	17	met	meet	VBN
cord-006229-7yoilsho	4657	18	inhibition	inhibition	NN
cord-006229-7yoilsho	4657	19	.	.	.
cord-006229-7yoilsho	4658	1	Of	of	IN
cord-006229-7yoilsho	4658	2	note	note	NN
cord-006229-7yoilsho	4658	3	,	,	,
cord-006229-7yoilsho	4658	4	c	c	NN
cord-006229-7yoilsho	4658	5	-	-	HYPH
cord-006229-7yoilsho	4658	6	met	meet	VBN
cord-006229-7yoilsho	4658	7	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	4658	8	as	as	RB
cord-006229-7yoilsho	4658	9	well	well	RB
cord-006229-7yoilsho	4658	10	as	as	IN
cord-006229-7yoilsho	4658	11	c	c	NN
cord-006229-7yoilsho	4658	12	-	-	HYPH
cord-006229-7yoilsho	4658	13	met	meet	VBN
cord-006229-7yoilsho	4658	14	-	-	HYPH
cord-006229-7yoilsho	4658	15	specific	specific	JJ
cord-006229-7yoilsho	4658	16	siRNAs	siRNAs	NNP
cord-006229-7yoilsho	4658	17	markedly	markedly	RB
cord-006229-7yoilsho	4658	18	induced	induce	VBN
cord-006229-7yoilsho	4658	19	SATB1	satb1	NN
cord-006229-7yoilsho	4658	20	expression	expression	NN
cord-006229-7yoilsho	4658	21	in	in	IN
cord-006229-7yoilsho	4658	22	gastric	gastric	JJ
cord-006229-7yoilsho	4658	23	cancer	cancer	NN
cord-006229-7yoilsho	4658	24	cells	cell	NNS
cord-006229-7yoilsho	4658	25	,	,	,
cord-006229-7yoilsho	4658	26	and	and	CC
cord-006229-7yoilsho	4658	27	the	the	DT
cord-006229-7yoilsho	4658	28	downregulation	downregulation	NN
cord-006229-7yoilsho	4658	29	of	of	IN
cord-006229-7yoilsho	4658	30	SATB1	satb1	NN
cord-006229-7yoilsho	4658	31	by	by	IN
cord-006229-7yoilsho	4658	32	siRNAs	siRNAs	NNP
cord-006229-7yoilsho	4658	33	completely	completely	RB
cord-006229-7yoilsho	4658	34	prevented	prevent	VBD
cord-006229-7yoilsho	4658	35	the	the	DT
cord-006229-7yoilsho	4658	36	induction	induction	NN
cord-006229-7yoilsho	4658	37	of	of	IN
cord-006229-7yoilsho	4658	38	HER3	HER3	NNP
cord-006229-7yoilsho	4658	39	upon	upon	IN
cord-006229-7yoilsho	4658	40	c	c	NNP
cord-006229-7yoilsho	4658	41	-	-	HYPH
cord-006229-7yoilsho	4658	42	met	meet	VBN
cord-006229-7yoilsho	4658	43	inhibition	inhibition	NN
cord-006229-7yoilsho	4658	44	.	.	.
cord-006229-7yoilsho	4659	1	In	in	IN
cord-006229-7yoilsho	4659	2	contrast	contrast	NN
cord-006229-7yoilsho	4659	3	,	,	,
cord-006229-7yoilsho	4659	4	HER1	HER1	NNP
cord-006229-7yoilsho	4659	5	or	or	CC
cord-006229-7yoilsho	4659	6	HER2	her2	JJ
cord-006229-7yoilsho	4659	7	expression	expression	NN
cord-006229-7yoilsho	4659	8	levels	level	NNS
cord-006229-7yoilsho	4659	9	were	be	VBD
cord-006229-7yoilsho	4659	10	not	not	RB
cord-006229-7yoilsho	4659	11	affected	affect	VBN
cord-006229-7yoilsho	4659	12	by	by	IN
cord-006229-7yoilsho	4659	13	SATB1-specific	SATB1-specific	NNP
cord-006229-7yoilsho	4659	14	siRNAs	siRNAs	NNP
cord-006229-7yoilsho	4659	15	.	.	.
cord-006229-7yoilsho	4660	1	The	the	DT
cord-006229-7yoilsho	4660	2	function	function	NN
cord-006229-7yoilsho	4660	3	of	of	IN
cord-006229-7yoilsho	4660	4	SATB1	satb1	NN
cord-006229-7yoilsho	4660	5	as	as	IN
cord-006229-7yoilsho	4660	6	transcriptional	transcriptional	JJ
cord-006229-7yoilsho	4660	7	regulator	regulator	NN
cord-006229-7yoilsho	4660	8	is	be	VBZ
cord-006229-7yoilsho	4660	9	controlled	control	VBN
cord-006229-7yoilsho	4660	10	by	by	IN
cord-006229-7yoilsho	4660	11	its	-PRON-	PRP$
cord-006229-7yoilsho	4660	12	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	4660	13	status	status	NN
cord-006229-7yoilsho	4660	14	,	,	,
cord-006229-7yoilsho	4660	15	which	which	WDT
cord-006229-7yoilsho	4660	16	in	in	IN
cord-006229-7yoilsho	4660	17	turn	turn	NN
cord-006229-7yoilsho	4660	18	is	be	VBZ
cord-006229-7yoilsho	4660	19	modulated	modulate	VBN
cord-006229-7yoilsho	4660	20	by	by	IN
cord-006229-7yoilsho	4660	21	PKC	PKC	NNP
cord-006229-7yoilsho	4660	22	activity	activity	NN
cord-006229-7yoilsho	4660	23	.	.	.
cord-006229-7yoilsho	4661	1	Thus	thus	RB
cord-006229-7yoilsho	4661	2	,	,	,
cord-006229-7yoilsho	4661	3	we	-PRON-	PRP
cord-006229-7yoilsho	4661	4	also	also	RB
cord-006229-7yoilsho	4661	5	tested	test	VBD
cord-006229-7yoilsho	4661	6	the	the	DT
cord-006229-7yoilsho	4661	7	effect	effect	NN
cord-006229-7yoilsho	4661	8	of	of	IN
cord-006229-7yoilsho	4661	9	PKC	PKC	NNP
cord-006229-7yoilsho	4661	10	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	4661	11	on	on	IN
cord-006229-7yoilsho	4661	12	HER3	HER3	NNP
cord-006229-7yoilsho	4661	13	expression	expression	NN
cord-006229-7yoilsho	4661	14	after	after	IN
cord-006229-7yoilsho	4661	15	c	c	NN
cord-006229-7yoilsho	4661	16	-	-	HYPH
cord-006229-7yoilsho	4661	17	met	meet	VBN
cord-006229-7yoilsho	4661	18	inhibition	inhibition	NN
cord-006229-7yoilsho	4661	19	.	.	.
cord-006229-7yoilsho	4662	1	Interestingly	interestingly	RB
cord-006229-7yoilsho	4662	2	,	,	,
cord-006229-7yoilsho	4662	3	the	the	DT
cord-006229-7yoilsho	4662	4	upregulation	upregulation	NN
cord-006229-7yoilsho	4662	5	of	of	IN
cord-006229-7yoilsho	4662	6	HER3	HER3	NNP
cord-006229-7yoilsho	4662	7	in	in	IN
cord-006229-7yoilsho	4662	8	gastric	gastric	JJ
cord-006229-7yoilsho	4662	9	cancer	cancer	NN
cord-006229-7yoilsho	4662	10	cells	cell	NNS
cord-006229-7yoilsho	4662	11	was	be	VBD
cord-006229-7yoilsho	4662	12	significantly	significantly	RB
cord-006229-7yoilsho	4662	13	reduced	reduce	VBN
cord-006229-7yoilsho	4662	14	by	by	IN
cord-006229-7yoilsho	4662	15	PKC	PKC	NNP
cord-006229-7yoilsho	4662	16	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	4662	17	.	.	.
cord-006229-7yoilsho	4663	1	To	to	TO
cord-006229-7yoilsho	4663	2	summarize	summarize	VB
cord-006229-7yoilsho	4663	3	,	,	,
cord-006229-7yoilsho	4663	4	SATB1	SATB1	NNP
cord-006229-7yoilsho	4663	5	and	and	CC
cord-006229-7yoilsho	4663	6	PKC	PKC	NNP
cord-006229-7yoilsho	4663	7	are	be	VBP
cord-006229-7yoilsho	4663	8	critically	critically	RB
cord-006229-7yoilsho	4663	9	involved	involved	JJ
cord-006229-7yoilsho	4663	10	in	in	IN
cord-006229-7yoilsho	4663	11	the	the	DT
cord-006229-7yoilsho	4663	12	regulation	regulation	NN
cord-006229-7yoilsho	4663	13	of	of	IN
cord-006229-7yoilsho	4663	14	HER3	HER3	NNP
cord-006229-7yoilsho	4663	15	expression	expression	NN
cord-006229-7yoilsho	4663	16	in	in	IN
cord-006229-7yoilsho	4663	17	gastric	gastric	JJ
cord-006229-7yoilsho	4663	18	cancer	cancer	NN
cord-006229-7yoilsho	4663	19	cells	cell	NNS
cord-006229-7yoilsho	4663	20	after	after	IN
cord-006229-7yoilsho	4663	21	treatment	treatment	NN
cord-006229-7yoilsho	4663	22	with	with	IN
cord-006229-7yoilsho	4663	23	c	c	NN
cord-006229-7yoilsho	4663	24	-	-	HYPH
cord-006229-7yoilsho	4663	25	met	meet	VBN
cord-006229-7yoilsho	4663	26	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	4663	27	and	and	CC
cord-006229-7yoilsho	4663	28	the	the	DT
cord-006229-7yoilsho	4663	29	oncogene	oncogene	NN
cord-006229-7yoilsho	4663	30	HER3	HER3	NNP
cord-006229-7yoilsho	4663	31	plays	play	VBZ
cord-006229-7yoilsho	4663	32	a	a	DT
cord-006229-7yoilsho	4663	33	crucial	crucial	JJ
cord-006229-7yoilsho	4663	34	role	role	NN
cord-006229-7yoilsho	4663	35	for	for	IN
cord-006229-7yoilsho	4663	36	tumor	tumor	NN
cord-006229-7yoilsho	4663	37	cell	cell	NN
cord-006229-7yoilsho	4663	38	survival	survival	NN
cord-006229-7yoilsho	4663	39	in	in	IN
cord-006229-7yoilsho	4663	40	this	this	DT
cord-006229-7yoilsho	4663	41	context	context	NN
cord-006229-7yoilsho	4663	42	.	.	.
cord-006229-7yoilsho	4664	1	Thus	thus	RB
cord-006229-7yoilsho	4664	2	,	,	,
cord-006229-7yoilsho	4664	3	inhibition	inhibition	NN
cord-006229-7yoilsho	4664	4	of	of	IN
cord-006229-7yoilsho	4664	5	PKC	PKC	NNP
cord-006229-7yoilsho	4664	6	or	or	CC
cord-006229-7yoilsho	4664	7	SATB1	SATB1	NNP
cord-006229-7yoilsho	4664	8	may	may	MD
cord-006229-7yoilsho	4664	9	help	help	VB
cord-006229-7yoilsho	4664	10	to	to	TO
cord-006229-7yoilsho	4664	11	overcome	overcome	VB
cord-006229-7yoilsho	4664	12	resistance	resistance	NN
cord-006229-7yoilsho	4664	13	against	against	IN
cord-006229-7yoilsho	4664	14	c	c	NN
cord-006229-7yoilsho	4664	15	-	-	HYPH
cord-006229-7yoilsho	4664	16	met	meet	VBN
cord-006229-7yoilsho	4664	17	inhibition	inhibition	NN
cord-006229-7yoilsho	4664	18	in	in	IN
cord-006229-7yoilsho	4664	19	this	this	DT
cord-006229-7yoilsho	4664	20	tumor	tumor	NN
cord-006229-7yoilsho	4664	21	entitiy	entitiy	NN
cord-006229-7yoilsho	4664	22	.	.	.
cord-006229-7yoilsho	4665	1	In	in	IN
cord-006229-7yoilsho	4665	2	the	the	DT
cord-006229-7yoilsho	4665	3	rising	rise	VBG
cord-006229-7yoilsho	4665	4	field	field	NN
cord-006229-7yoilsho	4665	5	of	of	IN
cord-006229-7yoilsho	4665	6	nanomedicine	nanomedicine	NN
cord-006229-7yoilsho	4665	7	,	,	,
cord-006229-7yoilsho	4665	8	development	development	NN
cord-006229-7yoilsho	4665	9	of	of	IN
cord-006229-7yoilsho	4665	10	new	new	JJ
cord-006229-7yoilsho	4665	11	approaches	approach	NNS
cord-006229-7yoilsho	4665	12	in	in	IN
cord-006229-7yoilsho	4665	13	diagnosis	diagnosis	NN
cord-006229-7yoilsho	4665	14	and	and	CC
cord-006229-7yoilsho	4665	15	treatment	treatment	NN
cord-006229-7yoilsho	4665	16	of	of	IN
cord-006229-7yoilsho	4665	17	cancer	cancer	NN
cord-006229-7yoilsho	4665	18	is	be	VBZ
cord-006229-7yoilsho	4665	19	a	a	DT
cord-006229-7yoilsho	4665	20	challenging	challenging	JJ
cord-006229-7yoilsho	4665	21	task	task	NN
cord-006229-7yoilsho	4665	22	.	.	.
cord-006229-7yoilsho	4666	1	Typically	typically	RB
cord-006229-7yoilsho	4666	2	,	,	,
cord-006229-7yoilsho	4666	3	a	a	DT
cord-006229-7yoilsho	4666	4	nanocarrier	nanocarrier	NN
cord-006229-7yoilsho	4666	5	is	be	VBZ
cord-006229-7yoilsho	4666	6	synthesized	synthesize	VBN
cord-006229-7yoilsho	4666	7	and	and	CC
cord-006229-7yoilsho	4666	8	linked	link	VBN
cord-006229-7yoilsho	4666	9	to	to	IN
cord-006229-7yoilsho	4666	10	functional	functional	JJ
cord-006229-7yoilsho	4666	11	compounds	compound	NNS
cord-006229-7yoilsho	4666	12	displaying	display	VBG
cord-006229-7yoilsho	4666	13	either	either	CC
cord-006229-7yoilsho	4666	14	diagnostic	diagnostic	JJ
cord-006229-7yoilsho	4666	15	or	or	CC
cord-006229-7yoilsho	4666	16	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	4666	17	effects	effect	NNS
cord-006229-7yoilsho	4666	18	in	in	IN
cord-006229-7yoilsho	4666	19	cancer	cancer	NN
cord-006229-7yoilsho	4666	20	models	model	NNS
cord-006229-7yoilsho	4666	21	.	.	.
cord-006229-7yoilsho	4667	1	Recently	recently	RB
cord-006229-7yoilsho	4667	2	,	,	,
cord-006229-7yoilsho	4667	3	nanomaterials	nanomaterial	NNS
cord-006229-7yoilsho	4667	4	combining	combine	VBG
cord-006229-7yoilsho	4667	5	both	both	CC
cord-006229-7yoilsho	4667	6	diagnostic	diagnostic	JJ
cord-006229-7yoilsho	4667	7	and	and	CC
cord-006229-7yoilsho	4667	8	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	4667	9	properties	property	NNS
cord-006229-7yoilsho	4667	10	,	,	,
cord-006229-7yoilsho	4667	11	so	so	RB
cord-006229-7yoilsho	4667	12	-	-	HYPH
cord-006229-7yoilsho	4667	13	called	call	VBN
cord-006229-7yoilsho	4667	14	'	'	``
cord-006229-7yoilsho	4667	15	theranostics	theranostic	NNS
cord-006229-7yoilsho	4667	16	'	'	''
cord-006229-7yoilsho	4667	17	,	,	,
cord-006229-7yoilsho	4667	18	became	become	VBD
cord-006229-7yoilsho	4667	19	of	of	IN
cord-006229-7yoilsho	4667	20	primary	primary	JJ
cord-006229-7yoilsho	4667	21	interest	interest	NN
cord-006229-7yoilsho	4667	22	.	.	.
cord-006229-7yoilsho	4668	1	Here	here	RB
cord-006229-7yoilsho	4668	2	we	-PRON-	PRP
cord-006229-7yoilsho	4668	3	used	use	VBD
cord-006229-7yoilsho	4668	4	a	a	DT
cord-006229-7yoilsho	4668	5	human	human	JJ
cord-006229-7yoilsho	4668	6	albumin	albumin	NN
cord-006229-7yoilsho	4668	7	-	-	HYPH
cord-006229-7yoilsho	4668	8	polyethylene	polyethylene	NN
cord-006229-7yoilsho	4668	9	glycol	glycol	NN
cord-006229-7yoilsho	4668	10	(	(	-LRB-
cord-006229-7yoilsho	4668	11	PEG	PEG	NNP
cord-006229-7yoilsho	4668	12	)	)	-RRB-
cord-006229-7yoilsho	4668	13	copolymer	copolymer	NN
cord-006229-7yoilsho	4668	14	(	(	-LRB-
cord-006229-7yoilsho	4668	15	HSA	HSA	NNP
cord-006229-7yoilsho	4668	16	)	)	-RRB-
cord-006229-7yoilsho	4668	17	as	as	IN
cord-006229-7yoilsho	4668	18	a	a	DT
cord-006229-7yoilsho	4668	19	theranostic	theranostic	JJ
cord-006229-7yoilsho	4668	20	platform	platform	NN
cord-006229-7yoilsho	4668	21	for	for	IN
cord-006229-7yoilsho	4668	22	molecular	molecular	JJ
cord-006229-7yoilsho	4668	23	integration	integration	NN
cord-006229-7yoilsho	4668	24	of	of	IN
cord-006229-7yoilsho	4668	25	the	the	DT
cord-006229-7yoilsho	4668	26	chemotherapeutic	chemotherapeutic	JJ
cord-006229-7yoilsho	4668	27	drug	drug	NN
cord-006229-7yoilsho	4668	28	doxorubicin	doxorubicin	NN
cord-006229-7yoilsho	4668	29	(	(	-LRB-
cord-006229-7yoilsho	4668	30	Dox	Dox	NNP
cord-006229-7yoilsho	4668	31	)	)	-RRB-
cord-006229-7yoilsho	4668	32	and	and	CC
cord-006229-7yoilsho	4668	33	the	the	DT
cord-006229-7yoilsho	4668	34	magnet	magnet	NN
cord-006229-7yoilsho	4668	35	resonance	resonance	NN
cord-006229-7yoilsho	4668	36	imaging	imaging	NN
cord-006229-7yoilsho	4668	37	(	(	-LRB-
cord-006229-7yoilsho	4668	38	MRI	MRI	NNP
cord-006229-7yoilsho	4668	39	)	)	-RRB-
cord-006229-7yoilsho	4668	40	contrast	contrast	NN
cord-006229-7yoilsho	4668	41	agent	agent	NN
cord-006229-7yoilsho	4668	42	gadolinium	gadolinium	NNP
cord-006229-7yoilsho	4668	43	(	(	-LRB-
cord-006229-7yoilsho	4668	44	Gd	Gd	NNP
cord-006229-7yoilsho	4668	45	)	)	-RRB-
cord-006229-7yoilsho	4668	46	yielding	yielding	JJ
cord-006229-7yoilsho	4668	47	Gd	Gd	NNP
cord-006229-7yoilsho	4668	48	-	-	HYPH
cord-006229-7yoilsho	4668	49	HSA	HSA	NNP
cord-006229-7yoilsho	4668	50	-	-	HYPH
cord-006229-7yoilsho	4668	51	Dox	Dox	NNP
cord-006229-7yoilsho	4668	52	nanoparticles	nanoparticle	NNS
cord-006229-7yoilsho	4668	53	.	.	.
cord-006229-7yoilsho	4669	1	Besides	besides	IN
cord-006229-7yoilsho	4669	2	in	in	IN
cord-006229-7yoilsho	4669	3	vitro	vitro	FW
cord-006229-7yoilsho	4669	4	testing	testing	NN
cord-006229-7yoilsho	4669	5	,	,	,
cord-006229-7yoilsho	4669	6	which	which	WDT
cord-006229-7yoilsho	4669	7	demonstrated	demonstrate	VBD
cord-006229-7yoilsho	4669	8	cytotoxic	cytotoxic	JJ
cord-006229-7yoilsho	4669	9	efficacy	efficacy	NN
cord-006229-7yoilsho	4669	10	of	of	IN
cord-006229-7yoilsho	4669	11	Gd	Gd	NNP
cord-006229-7yoilsho	4669	12	-	-	HYPH
cord-006229-7yoilsho	4669	13	HSA	HSA	NNP
cord-006229-7yoilsho	4669	14	-	-	HYPH
cord-006229-7yoilsho	4669	15	Dox	Dox	NNP
cord-006229-7yoilsho	4669	16	,	,	,
cord-006229-7yoilsho	4669	17	we	-PRON-	PRP
cord-006229-7yoilsho	4669	18	used	use	VBD
cord-006229-7yoilsho	4669	19	the	the	DT
cord-006229-7yoilsho	4669	20	chorioallantoic	chorioallantoic	NNP
cord-006229-7yoilsho	4669	21	membrane	membrane	NNP
cord-006229-7yoilsho	4669	22	(	(	-LRB-
cord-006229-7yoilsho	4669	23	CAM	CAM	NNP
cord-006229-7yoilsho	4669	24	)	)	-RRB-
cord-006229-7yoilsho	4669	25	of	of	IN
cord-006229-7yoilsho	4669	26	fertilized	fertilize	VBN
cord-006229-7yoilsho	4669	27	chick	chick	NN
cord-006229-7yoilsho	4669	28	eggs	egg	NNS
cord-006229-7yoilsho	4669	29	as	as	IN
cord-006229-7yoilsho	4669	30	a	a	DT
cord-006229-7yoilsho	4669	31	preclinical	preclinical	JJ
cord-006229-7yoilsho	4669	32	xenotransplantation	xenotransplantation	NN
cord-006229-7yoilsho	4669	33	model	model	NN
cord-006229-7yoilsho	4669	34	.	.	.
cord-006229-7yoilsho	4670	1	The	the	DT
cord-006229-7yoilsho	4670	2	CAM	cam	NN
cord-006229-7yoilsho	4670	3	assay	assay	NN
cord-006229-7yoilsho	4670	4	,	,	,
cord-006229-7yoilsho	4670	5	which	which	WDT
cord-006229-7yoilsho	4670	6	in	in	IN
cord-006229-7yoilsho	4670	7	legal	legal	JJ
cord-006229-7yoilsho	4670	8	terms	term	NNS
cord-006229-7yoilsho	4670	9	does	do	VBZ
cord-006229-7yoilsho	4670	10	not	not	RB
cord-006229-7yoilsho	4670	11	represent	represent	VB
cord-006229-7yoilsho	4670	12	an	an	DT
cord-006229-7yoilsho	4670	13	animal	animal	NN
cord-006229-7yoilsho	4670	14	experiment	experiment	NN
cord-006229-7yoilsho	4670	15	,	,	,
cord-006229-7yoilsho	4670	16	allows	allow	VBZ
cord-006229-7yoilsho	4670	17	testing	testing	NN
cord-006229-7yoilsho	4670	18	of	of	IN
cord-006229-7yoilsho	4670	19	compounds	compound	NNS
cord-006229-7yoilsho	4670	20	in	in	IN
cord-006229-7yoilsho	4670	21	an	an	DT
cord-006229-7yoilsho	4670	22	in	in	IN
cord-006229-7yoilsho	4670	23	vivo	vivo	NN
cord-006229-7yoilsho	4670	24	setting	setting	NN
cord-006229-7yoilsho	4670	25	.	.	.
cord-006229-7yoilsho	4671	1	This	this	DT
cord-006229-7yoilsho	4671	2	model	model	NN
cord-006229-7yoilsho	4671	3	is	be	VBZ
cord-006229-7yoilsho	4671	4	particularly	particularly	RB
cord-006229-7yoilsho	4671	5	helpful	helpful	JJ
cord-006229-7yoilsho	4671	6	to	to	TO
cord-006229-7yoilsho	4671	7	narrow	narrow	VB
cord-006229-7yoilsho	4671	8	the	the	DT
cord-006229-7yoilsho	4671	9	gap	gap	NN
cord-006229-7yoilsho	4671	10	between	between	IN
cord-006229-7yoilsho	4671	11	in	in	IN
cord-006229-7yoilsho	4671	12	vitro	vitro	FW
cord-006229-7yoilsho	4671	13	and	and	CC
cord-006229-7yoilsho	4671	14	in	in	IN
cord-006229-7yoilsho	4671	15	vivo	vivo	NN
cord-006229-7yoilsho	4671	16	applications	application	NNS
cord-006229-7yoilsho	4671	17	in	in	IN
cord-006229-7yoilsho	4671	18	rodents	rodent	NNS
cord-006229-7yoilsho	4671	19	,	,	,
cord-006229-7yoilsho	4671	20	because	because	IN
cord-006229-7yoilsho	4671	21	it	-PRON-	PRP
cord-006229-7yoilsho	4671	22	can	can	MD
cord-006229-7yoilsho	4671	23	help	help	VB
cord-006229-7yoilsho	4671	24	to	to	TO
cord-006229-7yoilsho	4671	25	reduce	reduce	VB
cord-006229-7yoilsho	4671	26	number	number	NN
cord-006229-7yoilsho	4671	27	of	of	IN
cord-006229-7yoilsho	4671	28	elaborate	elaborate	JJ
cord-006229-7yoilsho	4671	29	experiments	experiment	NNS
cord-006229-7yoilsho	4671	30	with	with	IN
cord-006229-7yoilsho	4671	31	typically	typically	RB
cord-006229-7yoilsho	4671	32	nude	nude	JJ
cord-006229-7yoilsho	4671	33	mice	mouse	NNS
cord-006229-7yoilsho	4671	34	,	,	,
cord-006229-7yoilsho	4671	35	and	and	CC
cord-006229-7yoilsho	4671	36	it	-PRON-	PRP
cord-006229-7yoilsho	4671	37	reduces	reduce	VBZ
cord-006229-7yoilsho	4671	38	or	or	CC
cord-006229-7yoilsho	4671	39	even	even	RB
cord-006229-7yoilsho	4671	40	avoids	avoid	VBZ
cord-006229-7yoilsho	4671	41	exposure	exposure	NN
cord-006229-7yoilsho	4671	42	of	of	IN
cord-006229-7yoilsho	4671	43	those	those	DT
cord-006229-7yoilsho	4671	44	animals	animal	NNS
cord-006229-7yoilsho	4671	45	to	to	IN
cord-006229-7yoilsho	4671	46	adverse	adverse	JJ
cord-006229-7yoilsho	4671	47	effects	effect	NNS
cord-006229-7yoilsho	4671	48	and	and	CC
cord-006229-7yoilsho	4671	49	distress	distress	NN
cord-006229-7yoilsho	4671	50	.	.	.
cord-006229-7yoilsho	4672	1	Treatment	treatment	NN
cord-006229-7yoilsho	4672	2	-	-	HYPH
cord-006229-7yoilsho	4672	3	resistant	resistant	JJ
cord-006229-7yoilsho	4672	4	MDA	MDA	NNP
cord-006229-7yoilsho	4672	5	-	-	HYPH
cord-006229-7yoilsho	4672	6	MB-231	MB-231	NNP
cord-006229-7yoilsho	4672	7	breast	breast	NN
cord-006229-7yoilsho	4672	8	cancer	cancer	NN
cord-006229-7yoilsho	4672	9	cells	cell	NNS
cord-006229-7yoilsho	4672	10	stably	stably	RB
cord-006229-7yoilsho	4672	11	transfected	transfecte	VBN
cord-006229-7yoilsho	4672	12	with	with	IN
cord-006229-7yoilsho	4672	13	luciferase	luciferase	NNP
cord-006229-7yoilsho	4672	14	were	be	VBD
cord-006229-7yoilsho	4672	15	xenotransplanted	xenotransplante	VBN
cord-006229-7yoilsho	4672	16	onto	onto	IN
cord-006229-7yoilsho	4672	17	the	the	DT
cord-006229-7yoilsho	4672	18	chorioallantoic	chorioallantoic	NNP
cord-006229-7yoilsho	4672	19	membrane	membrane	NN
cord-006229-7yoilsho	4672	20	.	.	.
cord-006229-7yoilsho	4673	1	After	after	IN
cord-006229-7yoilsho	4673	2	formation	formation	NN
cord-006229-7yoilsho	4673	3	of	of	IN
cord-006229-7yoilsho	4673	4	solid	solid	JJ
cord-006229-7yoilsho	4673	5	breast	breast	NN
cord-006229-7yoilsho	4673	6	cancer	cancer	NN
cord-006229-7yoilsho	4673	7	xenografts	xenograft	NNS
cord-006229-7yoilsho	4673	8	,	,	,
cord-006229-7yoilsho	4673	9	Gd	Gd	NNP
cord-006229-7yoilsho	4673	10	-	-	HYPH
cord-006229-7yoilsho	4673	11	HSA	HSA	NNP
cord-006229-7yoilsho	4673	12	-	-	HYPH
cord-006229-7yoilsho	4673	13	Dox	Dox	NNP
cord-006229-7yoilsho	4673	14	was	be	VBD
cord-006229-7yoilsho	4673	15	injected	inject	VBN
cord-006229-7yoilsho	4673	16	intravenously	intravenously	RB
cord-006229-7yoilsho	4673	17	and	and	CC
cord-006229-7yoilsho	4673	18	its	-PRON-	PRP$
cord-006229-7yoilsho	4673	19	antiproliferative	antiproliferative	JJ
cord-006229-7yoilsho	4673	20	effect	effect	NN
cord-006229-7yoilsho	4673	21	was	be	VBD
cord-006229-7yoilsho	4673	22	evaluated	evaluate	VBN
cord-006229-7yoilsho	4673	23	by	by	IN
cord-006229-7yoilsho	4673	24	IVIS	IVIS	NNP
cord-006229-7yoilsho	4673	25	imaging	imaging	NN
cord-006229-7yoilsho	4673	26	of	of	IN
cord-006229-7yoilsho	4673	27	luciferase	luciferase	JJ
cord-006229-7yoilsho	4673	28	activity	activity	NN
cord-006229-7yoilsho	4673	29	and	and	CC
cord-006229-7yoilsho	4673	30	by	by	IN
cord-006229-7yoilsho	4673	31	immunohistochemical	immunohistochemical	JJ
cord-006229-7yoilsho	4673	32	analysis	analysis	NN
cord-006229-7yoilsho	4673	33	of	of	IN
cord-006229-7yoilsho	4673	34	the	the	DT
cord-006229-7yoilsho	4673	35	tumor	tumor	NN
cord-006229-7yoilsho	4673	36	xenografts	xenograft	NNS
cord-006229-7yoilsho	4673	37	for	for	IN
cord-006229-7yoilsho	4673	38	the	the	DT
cord-006229-7yoilsho	4673	39	Ki-67	Ki-67	NNP
cord-006229-7yoilsho	4673	40	proliferation	proliferation	NN
cord-006229-7yoilsho	4673	41	antigen	antigen	NN
cord-006229-7yoilsho	4673	42	.	.	.
cord-006229-7yoilsho	4674	1	In	in	IN
cord-006229-7yoilsho	4674	2	comparison	comparison	NN
cord-006229-7yoilsho	4674	3	to	to	IN
cord-006229-7yoilsho	4674	4	conventional	conventional	JJ
cord-006229-7yoilsho	4674	5	Dox	Dox	NNP
cord-006229-7yoilsho	4674	6	,	,	,
cord-006229-7yoilsho	4674	7	Gd	Gd	NNP
cord-006229-7yoilsho	4674	8	-	-	HYPH
cord-006229-7yoilsho	4674	9	HSA	HSA	NNP
cord-006229-7yoilsho	4674	10	-	-	HYPH
cord-006229-7yoilsho	4674	11	Dox	Dox	NNP
cord-006229-7yoilsho	4674	12	showed	show	VBD
cord-006229-7yoilsho	4674	13	increased	increase	VBN
cord-006229-7yoilsho	4674	14	antiproliferative	antiproliferative	JJ
cord-006229-7yoilsho	4674	15	efficacy	efficacy	NN
cord-006229-7yoilsho	4674	16	and	and	CC
cord-006229-7yoilsho	4674	17	reduced	reduce	VBN
cord-006229-7yoilsho	4674	18	general	general	JJ
cord-006229-7yoilsho	4674	19	toxicity	toxicity	NN
cord-006229-7yoilsho	4674	20	in	in	IN
cord-006229-7yoilsho	4674	21	the	the	DT
cord-006229-7yoilsho	4674	22	CAM	cam	NN
cord-006229-7yoilsho	4674	23	assay	assay	NN
cord-006229-7yoilsho	4674	24	.	.	.
cord-006229-7yoilsho	4675	1	On	on	IN
cord-006229-7yoilsho	4675	2	the	the	DT
cord-006229-7yoilsho	4675	3	basis	basis	NN
cord-006229-7yoilsho	4675	4	of	of	IN
cord-006229-7yoilsho	4675	5	these	these	DT
cord-006229-7yoilsho	4675	6	findings	finding	NNS
cord-006229-7yoilsho	4675	7	,	,	,
cord-006229-7yoilsho	4675	8	a	a	DT
cord-006229-7yoilsho	4675	9	rodent	rodent	NN
cord-006229-7yoilsho	4675	10	model	model	NN
cord-006229-7yoilsho	4675	11	was	be	VBD
cord-006229-7yoilsho	4675	12	established	establish	VBN
cord-006229-7yoilsho	4675	13	,	,	,
cord-006229-7yoilsho	4675	14	where	where	WRB
cord-006229-7yoilsho	4675	15	the	the	DT
cord-006229-7yoilsho	4675	16	MDA	MDA	NNP
cord-006229-7yoilsho	4675	17	-	-	HYPH
cord-006229-7yoilsho	4675	18	MB-231	MB-231	NNP
cord-006229-7yoilsho	4675	19	breast	breast	NN
cord-006229-7yoilsho	4675	20	cancer	cancer	NN
cord-006229-7yoilsho	4675	21	cells	cell	NNS
cord-006229-7yoilsho	4675	22	were	be	VBD
cord-006229-7yoilsho	4675	23	orthotopically	orthotopically	RB
cord-006229-7yoilsho	4675	24	xenotransplanted	xenotransplante	VBN
cord-006229-7yoilsho	4675	25	into	into	IN
cord-006229-7yoilsho	4675	26	the	the	DT
cord-006229-7yoilsho	4675	27	mammary	mammary	JJ
cord-006229-7yoilsho	4675	28	fat	fat	JJ
cord-006229-7yoilsho	4675	29	pads	pad	NNS
cord-006229-7yoilsho	4675	30	of	of	IN
cord-006229-7yoilsho	4675	31	female	female	JJ
cord-006229-7yoilsho	4675	32	NMRI	NMRI	NNP
cord-006229-7yoilsho	4675	33	nu	nu	NNP
cord-006229-7yoilsho	4675	34	/	/	SYM
cord-006229-7yoilsho	4675	35	nu	nu	NNP
cord-006229-7yoilsho	4675	36	mice	mouse	NNS
cord-006229-7yoilsho	4675	37	.	.	.
cord-006229-7yoilsho	4676	1	In	in	IN
cord-006229-7yoilsho	4676	2	this	this	DT
cord-006229-7yoilsho	4676	3	model	model	NN
cord-006229-7yoilsho	4676	4	,	,	,
cord-006229-7yoilsho	4676	5	we	-PRON-	PRP
cord-006229-7yoilsho	4676	6	further	further	RB
cord-006229-7yoilsho	4676	7	investigated	investigate	VBD
cord-006229-7yoilsho	4676	8	biocompatibility	biocompatibility	NN
cord-006229-7yoilsho	4676	9	,	,	,
cord-006229-7yoilsho	4676	10	as	as	RB
cord-006229-7yoilsho	4676	11	well	well	RB
cord-006229-7yoilsho	4676	12	as	as	IN
cord-006229-7yoilsho	4676	13	diagnostic	diagnostic	JJ
cord-006229-7yoilsho	4676	14	and	and	CC
cord-006229-7yoilsho	4676	15	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	4676	16	properties	property	NNS
cord-006229-7yoilsho	4676	17	of	of	IN
cord-006229-7yoilsho	4676	18	the	the	DT
cord-006229-7yoilsho	4676	19	engineered	engineer	VBN
cord-006229-7yoilsho	4676	20	nanomaterial	nanomaterial	NN
cord-006229-7yoilsho	4676	21	.	.	.
cord-006229-7yoilsho	4677	1	After	after	IN
cord-006229-7yoilsho	4677	2	repeated	repeat	VBN
cord-006229-7yoilsho	4677	3	administration	administration	NN
cord-006229-7yoilsho	4677	4	of	of	IN
cord-006229-7yoilsho	4677	5	Gd	Gd	NNP
cord-006229-7yoilsho	4677	6	-	-	HYPH
cord-006229-7yoilsho	4677	7	HSA	HSA	NNP
cord-006229-7yoilsho	4677	8	-	-	HYPH
cord-006229-7yoilsho	4677	9	Dox	Dox	NNP
cord-006229-7yoilsho	4677	10	into	into	IN
cord-006229-7yoilsho	4677	11	the	the	DT
cord-006229-7yoilsho	4677	12	tail	tail	NN
cord-006229-7yoilsho	4677	13	vein	vein	NN
cord-006229-7yoilsho	4677	14	of	of	IN
cord-006229-7yoilsho	4677	15	the	the	DT
cord-006229-7yoilsho	4677	16	animals	animal	NNS
cord-006229-7yoilsho	4677	17	,	,	,
cord-006229-7yoilsho	4677	18	biocompatibility	biocompatibility	NN
cord-006229-7yoilsho	4677	19	of	of	IN
cord-006229-7yoilsho	4677	20	Gd	Gd	NNP
cord-006229-7yoilsho	4677	21	-	-	HYPH
cord-006229-7yoilsho	4677	22	HSA	HSA	NNP
cord-006229-7yoilsho	4677	23	-	-	HYPH
cord-006229-7yoilsho	4677	24	Dox	Dox	NNP
cord-006229-7yoilsho	4677	25	was	be	VBD
cord-006229-7yoilsho	4677	26	confirmed	confirm	VBN
cord-006229-7yoilsho	4677	27	by	by	IN
cord-006229-7yoilsho	4677	28	uncompromised	uncompromised	JJ
cord-006229-7yoilsho	4677	29	liver	liver	NN
cord-006229-7yoilsho	4677	30	,	,	,
cord-006229-7yoilsho	4677	31	kidney	kidney	NN
cord-006229-7yoilsho	4677	32	and	and	CC
cord-006229-7yoilsho	4677	33	hematopoietic	hematopoietic	JJ
cord-006229-7yoilsho	4677	34	parameters	parameter	NNS
cord-006229-7yoilsho	4677	35	.	.	.
cord-006229-7yoilsho	4678	1	To	to	TO
cord-006229-7yoilsho	4678	2	warrant	warrant	VB
cord-006229-7yoilsho	4678	3	diagnostic	diagnostic	JJ
cord-006229-7yoilsho	4678	4	properties	property	NNS
cord-006229-7yoilsho	4678	5	,	,	,
cord-006229-7yoilsho	4678	6	accumulation	accumulation	NN
cord-006229-7yoilsho	4678	7	of	of	IN
cord-006229-7yoilsho	4678	8	the	the	DT
cord-006229-7yoilsho	4678	9	nanomaterial	nanomaterial	JJ
cord-006229-7yoilsho	4678	10	in	in	IN
cord-006229-7yoilsho	4678	11	tumor	tumor	NN
cord-006229-7yoilsho	4678	12	tissue	tissue	NN
cord-006229-7yoilsho	4678	13	is	be	VBZ
cord-006229-7yoilsho	4678	14	indispensable	indispensable	JJ
cord-006229-7yoilsho	4678	15	.	.	.
cord-006229-7yoilsho	4679	1	By	by	IN
cord-006229-7yoilsho	4679	2	small	small	JJ
cord-006229-7yoilsho	4679	3	animal	animal	NN
cord-006229-7yoilsho	4679	4	MRI	MRI	NNP
cord-006229-7yoilsho	4679	5	of	of	IN
cord-006229-7yoilsho	4679	6	Gd	Gd	NNP
cord-006229-7yoilsho	4679	7	,	,	,
cord-006229-7yoilsho	4679	8	kinetics	kinetic	NNS
cord-006229-7yoilsho	4679	9	of	of	IN
cord-006229-7yoilsho	4679	10	intravenously	intravenously	RB
cord-006229-7yoilsho	4679	11	applied	apply	VBN
cord-006229-7yoilsho	4679	12	Gd	Gd	NNP
cord-006229-7yoilsho	4679	13	-	-	HYPH
cord-006229-7yoilsho	4679	14	HSA	HSA	NNP
cord-006229-7yoilsho	4679	15	-	-	HYPH
cord-006229-7yoilsho	4679	16	Dox	Dox	NNP
cord-006229-7yoilsho	4679	17	in	in	IN
cord-006229-7yoilsho	4679	18	tumor	tumor	NN
cord-006229-7yoilsho	4679	19	tissue	tissue	NN
cord-006229-7yoilsho	4679	20	was	be	VBD
cord-006229-7yoilsho	4679	21	monitored	monitor	VBN
cord-006229-7yoilsho	4679	22	.	.	.
cord-006229-7yoilsho	4680	1	An	an	DT
cord-006229-7yoilsho	4680	2	enhancement	enhancement	NN
cord-006229-7yoilsho	4680	3	of	of	IN
cord-006229-7yoilsho	4680	4	the	the	DT
cord-006229-7yoilsho	4680	5	engineered	engineer	VBN
cord-006229-7yoilsho	4680	6	nanomaterial	nanomaterial	NN
cord-006229-7yoilsho	4680	7	in	in	IN
cord-006229-7yoilsho	4680	8	tumor	tumor	NN
cord-006229-7yoilsho	4680	9	tissue	tissue	NN
cord-006229-7yoilsho	4680	10	was	be	VBD
cord-006229-7yoilsho	4680	11	detected	detect	VBN
cord-006229-7yoilsho	4680	12	for	for	IN
cord-006229-7yoilsho	4680	13	up	up	IN
cord-006229-7yoilsho	4680	14	to	to	TO
cord-006229-7yoilsho	4680	15	47	47	CD
cord-006229-7yoilsho	4680	16	h	h	NN
cord-006229-7yoilsho	4680	17	after	after	IN
cord-006229-7yoilsho	4680	18	injection	injection	NN
cord-006229-7yoilsho	4680	19	indicating	indicate	VBG
cord-006229-7yoilsho	4680	20	successful	successful	JJ
cord-006229-7yoilsho	4680	21	enrichment	enrichment	NN
cord-006229-7yoilsho	4680	22	of	of	IN
cord-006229-7yoilsho	4680	23	Gd	Gd	NNP
cord-006229-7yoilsho	4680	24	-	-	HYPH
cord-006229-7yoilsho	4680	25	HSA	HSA	NNP
cord-006229-7yoilsho	4680	26	-	-	HYPH
cord-006229-7yoilsho	4680	27	Dox	Dox	NNP
cord-006229-7yoilsho	4680	28	within	within	IN
cord-006229-7yoilsho	4680	29	the	the	DT
cord-006229-7yoilsho	4680	30	tumor	tumor	NN
cord-006229-7yoilsho	4680	31	tissue	tissue	NN
cord-006229-7yoilsho	4680	32	,	,	,
cord-006229-7yoilsho	4680	33	which	which	WDT
cord-006229-7yoilsho	4680	34	can	can	MD
cord-006229-7yoilsho	4680	35	be	be	VB
cord-006229-7yoilsho	4680	36	ascribed	ascribe	VBN
cord-006229-7yoilsho	4680	37	to	to	IN
cord-006229-7yoilsho	4680	38	the	the	DT
cord-006229-7yoilsho	4680	39	enhanced	enhance	VBN
cord-006229-7yoilsho	4680	40	permeability	permeability	NN
cord-006229-7yoilsho	4680	41	and	and	CC
cord-006229-7yoilsho	4680	42	retention	retention	NN
cord-006229-7yoilsho	4680	43	(	(	-LRB-
cord-006229-7yoilsho	4680	44	EPR	EPR	NNP
cord-006229-7yoilsho	4680	45	)	)	-RRB-
cord-006229-7yoilsho	4680	46	effect	effect	NN
cord-006229-7yoilsho	4680	47	observed	observe	VBN
cord-006229-7yoilsho	4680	48	in	in	IN
cord-006229-7yoilsho	4680	49	the	the	DT
cord-006229-7yoilsho	4680	50	microenvironment	microenvironment	NN
cord-006229-7yoilsho	4680	51	of	of	IN
cord-006229-7yoilsho	4680	52	many	many	JJ
cord-006229-7yoilsho	4680	53	solid	solid	JJ
cord-006229-7yoilsho	4680	54	tumor	tumor	NN
cord-006229-7yoilsho	4680	55	tissues	tissue	NNS
cord-006229-7yoilsho	4680	56	.	.	.
cord-006229-7yoilsho	4681	1	We	-PRON-	PRP
cord-006229-7yoilsho	4681	2	are	be	VBP
cord-006229-7yoilsho	4681	3	currently	currently	RB
cord-006229-7yoilsho	4681	4	investigating	investigate	VBG
cord-006229-7yoilsho	4681	5	the	the	DT
cord-006229-7yoilsho	4681	6	antitumor	antitumor	JJ
cord-006229-7yoilsho	4681	7	efficacy	efficacy	NN
cord-006229-7yoilsho	4681	8	of	of	IN
cord-006229-7yoilsho	4681	9	Gd	Gd	NNP
cord-006229-7yoilsho	4681	10	-	-	HYPH
cord-006229-7yoilsho	4681	11	HAS	have	VBZ
cord-006229-7yoilsho	4681	12	-	-	HYPH
cord-006229-7yoilsho	4681	13	Dox	Dox	NNP
cord-006229-7yoilsho	4681	14	in	in	IN
cord-006229-7yoilsho	4681	15	this	this	DT
cord-006229-7yoilsho	4681	16	mouse	mouse	NN
cord-006229-7yoilsho	4681	17	model	model	NN
cord-006229-7yoilsho	4681	18	and	and	CC
cord-006229-7yoilsho	4681	19	preliminary	preliminary	JJ
cord-006229-7yoilsho	4681	20	data	datum	NNS
cord-006229-7yoilsho	4681	21	seem	seem	VBP
cord-006229-7yoilsho	4681	22	to	to	TO
cord-006229-7yoilsho	4681	23	indicate	indicate	VB
cord-006229-7yoilsho	4681	24	a	a	DT
cord-006229-7yoilsho	4681	25	dose	dose	NN
cord-006229-7yoilsho	4681	26	-	-	HYPH
cord-006229-7yoilsho	4681	27	dependent	dependent	JJ
cord-006229-7yoilsho	4681	28	anticancer	anticancer	JJ
cord-006229-7yoilsho	4681	29	effect	effect	NN
cord-006229-7yoilsho	4681	30	.	.	.
cord-006229-7yoilsho	4682	1	Supported	support	VBN
cord-006229-7yoilsho	4682	2	by	by	IN
cord-006229-7yoilsho	4682	3	the	the	DT
cord-006229-7yoilsho	4682	4	VolkswagenStiftung	VolkswagenStiftung	NNP
cord-006229-7yoilsho	4682	5	.	.	.
cord-006229-7yoilsho	4683	1	Tubulin	Tubulin	NNP
cord-006229-7yoilsho	4683	2	-	-	HYPH
cord-006229-7yoilsho	4683	3	binding	bind	VBG
cord-006229-7yoilsho	4683	4	agents	agent	NNS
cord-006229-7yoilsho	4683	5	are	be	VBP
cord-006229-7yoilsho	4683	6	the	the	DT
cord-006229-7yoilsho	4683	7	most	most	RBS
cord-006229-7yoilsho	4683	8	important	important	JJ
cord-006229-7yoilsho	4683	9	anti	anti	JJ
cord-006229-7yoilsho	4683	10	-	-	JJ
cord-006229-7yoilsho	4683	11	tumoral	tumoral	JJ
cord-006229-7yoilsho	4683	12	drugs	drug	NNS
cord-006229-7yoilsho	4683	13	.	.	.
cord-006229-7yoilsho	4684	1	Due	due	IN
cord-006229-7yoilsho	4684	2	to	to	IN
cord-006229-7yoilsho	4684	3	the	the	DT
cord-006229-7yoilsho	4684	4	side	side	NN
cord-006229-7yoilsho	4684	5	effects	effect	NNS
cord-006229-7yoilsho	4684	6	and	and	CC
cord-006229-7yoilsho	4684	7	the	the	DT
cord-006229-7yoilsho	4684	8	development	development	NN
cord-006229-7yoilsho	4684	9	of	of	IN
cord-006229-7yoilsho	4684	10	resistances	resistance	NNS
cord-006229-7yoilsho	4684	11	,	,	,
cord-006229-7yoilsho	4684	12	the	the	DT
cord-006229-7yoilsho	4684	13	discovery	discovery	NN
cord-006229-7yoilsho	4684	14	of	of	IN
cord-006229-7yoilsho	4684	15	new	new	JJ
cord-006229-7yoilsho	4684	16	agents	agent	NNS
cord-006229-7yoilsho	4684	17	is	be	VBZ
cord-006229-7yoilsho	4684	18	still	still	RB
cord-006229-7yoilsho	4684	19	of	of	IN
cord-006229-7yoilsho	4684	20	importance	importance	NN
cord-006229-7yoilsho	4684	21	.	.	.
cord-006229-7yoilsho	4685	1	Recently	recently	RB
cord-006229-7yoilsho	4685	2	,	,	,
cord-006229-7yoilsho	4685	3	pretubulysin	pretubulysin	NNP
cord-006229-7yoilsho	4685	4	(	(	-LRB-
cord-006229-7yoilsho	4685	5	PT	PT	NNP
cord-006229-7yoilsho	4685	6	)	)	-RRB-
cord-006229-7yoilsho	4685	7	,	,	,
cord-006229-7yoilsho	4685	8	a	a	DT
cord-006229-7yoilsho	4685	9	naturally	naturally	RB
cord-006229-7yoilsho	4685	10	occurring	occur	VBG
cord-006229-7yoilsho	4685	11	precursor	precursor	NN
cord-006229-7yoilsho	4685	12	of	of	IN
cord-006229-7yoilsho	4685	13	the	the	DT
cord-006229-7yoilsho	4685	14	myxobacterial	myxobacterial	JJ
cord-006229-7yoilsho	4685	15	compound	compound	NNP
cord-006229-7yoilsho	4685	16	tubulysin	tubulysin	NNP
cord-006229-7yoilsho	4685	17	,	,	,
cord-006229-7yoilsho	4685	18	was	be	VBD
cord-006229-7yoilsho	4685	19	identified	identify	VBN
cord-006229-7yoilsho	4685	20	as	as	IN
cord-006229-7yoilsho	4685	21	a	a	DT
cord-006229-7yoilsho	4685	22	novel	novel	JJ
cord-006229-7yoilsho	4685	23	tubulin	tubulin	NN
cord-006229-7yoilsho	4685	24	-	-	HYPH
cord-006229-7yoilsho	4685	25	binding	bind	VBG
cord-006229-7yoilsho	4685	26	compound	compound	NN
cord-006229-7yoilsho	4685	27	.	.	.
cord-006229-7yoilsho	4686	1	In	in	IN
cord-006229-7yoilsho	4686	2	the	the	DT
cord-006229-7yoilsho	4686	3	DFG	DFG	NNP
cord-006229-7yoilsho	4686	4	research	research	NN
cord-006229-7yoilsho	4686	5	group	group	NN
cord-006229-7yoilsho	4686	6	FOR	for	IN
cord-006229-7yoilsho	4686	7	1406	1406	CD
cord-006229-7yoilsho	4686	8	,	,	,
cord-006229-7yoilsho	4686	9	PT	PT	NNP
cord-006229-7yoilsho	4686	10	was	be	VBD
cord-006229-7yoilsho	4686	11	characterized	characterize	VBN
cord-006229-7yoilsho	4686	12	as	as	IN
cord-006229-7yoilsho	4686	13	anti	anti	JJ
cord-006229-7yoilsho	4686	14	-	-	JJ
cord-006229-7yoilsho	4686	15	tumoral	tumoral	JJ
cord-006229-7yoilsho	4686	16	,	,	,
cord-006229-7yoilsho	4686	17	antiangiogenic	antiangiogenic	JJ
cord-006229-7yoilsho	4686	18	and	and	CC
cord-006229-7yoilsho	4686	19	vascular	vascular	RB
cord-006229-7yoilsho	4686	20	-	-	HYPH
cord-006229-7yoilsho	4686	21	disrupting	disrupt	VBG
cord-006229-7yoilsho	4686	22	compound	compound	NN
cord-006229-7yoilsho	4686	23	.	.	.
cord-006229-7yoilsho	4687	1	Moreover	moreover	RB
cord-006229-7yoilsho	4687	2	,	,	,
cord-006229-7yoilsho	4687	3	PT	PT	NNP
cord-006229-7yoilsho	4687	4	was	be	VBD
cord-006229-7yoilsho	4687	5	also	also	RB
cord-006229-7yoilsho	4687	6	found	find	VBN
cord-006229-7yoilsho	4687	7	to	to	TO
cord-006229-7yoilsho	4687	8	inhibit	inhibit	VB
cord-006229-7yoilsho	4687	9	the	the	DT
cord-006229-7yoilsho	4687	10	formation	formation	NN
cord-006229-7yoilsho	4687	11	of	of	IN
cord-006229-7yoilsho	4687	12	metastases	metastasis	NNS
cord-006229-7yoilsho	4687	13	in	in	IN
cord-006229-7yoilsho	4687	14	vivo	vivo	NN
cord-006229-7yoilsho	4687	15	.	.	.
cord-006229-7yoilsho	4688	1	Aim	aim	VB
cord-006229-7yoilsho	4688	2	of	of	IN
cord-006229-7yoilsho	4688	3	the	the	DT
cord-006229-7yoilsho	4688	4	present	present	JJ
cord-006229-7yoilsho	4688	5	study	study	NN
cord-006229-7yoilsho	4688	6	was	be	VBD
cord-006229-7yoilsho	4688	7	to	to	TO
cord-006229-7yoilsho	4688	8	gain	gain	VB
cord-006229-7yoilsho	4688	9	first	first	JJ
cord-006229-7yoilsho	4688	10	insights	insight	NNS
cord-006229-7yoilsho	4688	11	into	into	IN
cord-006229-7yoilsho	4688	12	the	the	DT
cord-006229-7yoilsho	4688	13	mechanisms	mechanism	NNS
cord-006229-7yoilsho	4688	14	underlying	underlie	VBG
cord-006229-7yoilsho	4688	15	this	this	DT
cord-006229-7yoilsho	4688	16	anti	anti	JJ
cord-006229-7yoilsho	4688	17	-	-	JJ
cord-006229-7yoilsho	4688	18	metastatic	metastatic	JJ
cord-006229-7yoilsho	4688	19	effect	effect	NN
cord-006229-7yoilsho	4688	20	by	by	IN
cord-006229-7yoilsho	4688	21	investigating	investigate	VBG
cord-006229-7yoilsho	4688	22	the	the	DT
cord-006229-7yoilsho	4688	23	influence	influence	NN
cord-006229-7yoilsho	4688	24	of	of	IN
cord-006229-7yoilsho	4688	25	PT	pt	NN
cord-006229-7yoilsho	4688	26	on	on	IN
cord-006229-7yoilsho	4688	27	the	the	DT
cord-006229-7yoilsho	4688	28	interaction	interaction	NN
cord-006229-7yoilsho	4688	29	of	of	IN
cord-006229-7yoilsho	4688	30	endothelial	endothelial	NN
cord-006229-7yoilsho	4688	31	and	and	CC
cord-006229-7yoilsho	4688	32	tumor	tumor	NN
cord-006229-7yoilsho	4688	33	cells	cell	NNS
cord-006229-7yoilsho	4688	34	in	in	IN
cord-006229-7yoilsho	4688	35	vitro	vitro	FW
cord-006229-7yoilsho	4688	36	.	.	.
cord-006229-7yoilsho	4689	1	PT	pt	NN
cord-006229-7yoilsho	4689	2	treatment	treatment	NN
cord-006229-7yoilsho	4689	3	of	of	IN
cord-006229-7yoilsho	4689	4	primary	primary	JJ
cord-006229-7yoilsho	4689	5	human	human	JJ
cord-006229-7yoilsho	4689	6	endothelial	endothelial	JJ
cord-006229-7yoilsho	4689	7	cells	cell	NNS
cord-006229-7yoilsho	4689	8	(	(	-LRB-
cord-006229-7yoilsho	4689	9	HUVECs	huvec	NNS
cord-006229-7yoilsho	4689	10	)	)	-RRB-
cord-006229-7yoilsho	4689	11	strongly	strongly	RB
cord-006229-7yoilsho	4689	12	increased	increase	VBD
cord-006229-7yoilsho	4689	13	the	the	DT
cord-006229-7yoilsho	4689	14	adhesion	adhesion	NN
cord-006229-7yoilsho	4689	15	of	of	IN
cord-006229-7yoilsho	4689	16	breast	breast	NN
cord-006229-7yoilsho	4689	17	cancer	cancer	NN
cord-006229-7yoilsho	4689	18	cells	cell	NNS
cord-006229-7yoilsho	4689	19	(	(	-LRB-
cord-006229-7yoilsho	4689	20	MDA	MDA	NNP
cord-006229-7yoilsho	4689	21	-	-	HYPH
cord-006229-7yoilsho	4689	22	MB-231	MB-231	NNP
cord-006229-7yoilsho	4689	23	)	)	-RRB-
cord-006229-7yoilsho	4689	24	on	on	IN
cord-006229-7yoilsho	4689	25	HUVECs	huvec	NNS
cord-006229-7yoilsho	4689	26	,	,	,
cord-006229-7yoilsho	4689	27	but	but	CC
cord-006229-7yoilsho	4689	28	limited	limit	VBD
cord-006229-7yoilsho	4689	29	their	-PRON-	PRP$
cord-006229-7yoilsho	4689	30	transmigration	transmigration	NN
cord-006229-7yoilsho	4689	31	through	through	IN
cord-006229-7yoilsho	4689	32	the	the	DT
cord-006229-7yoilsho	4689	33	endothelium	endothelium	NN
cord-006229-7yoilsho	4689	34	(	(	-LRB-
cord-006229-7yoilsho	4689	35	Transwell	Transwell	NNP
cord-006229-7yoilsho	4689	36	assay	assay	NN
cord-006229-7yoilsho	4689	37	)	)	-RRB-
cord-006229-7yoilsho	4689	38	.	.	.
cord-006229-7yoilsho	4690	1	Based	base	VBN
cord-006229-7yoilsho	4690	2	on	on	IN
cord-006229-7yoilsho	4690	3	this	this	DT
cord-006229-7yoilsho	4690	4	data	data	NN
cord-006229-7yoilsho	4690	5	,	,	,
cord-006229-7yoilsho	4690	6	the	the	DT
cord-006229-7yoilsho	4690	7	gene	gene	NN
cord-006229-7yoilsho	4690	8	expression	expression	NN
cord-006229-7yoilsho	4690	9	of	of	IN
cord-006229-7yoilsho	4690	10	presumably	presumably	RB
cord-006229-7yoilsho	4690	11	involved	involved	JJ
cord-006229-7yoilsho	4690	12	adhesion	adhesion	NN
cord-006229-7yoilsho	4690	13	molecules	molecule	NNS
cord-006229-7yoilsho	4690	14	was	be	VBD
cord-006229-7yoilsho	4690	15	determined	determine	VBN
cord-006229-7yoilsho	4690	16	by	by	IN
cord-006229-7yoilsho	4690	17	qRT	qRT	NNP
cord-006229-7yoilsho	4690	18	-	-	HYPH
cord-006229-7yoilsho	4690	19	PCR	PCR	NNP
cord-006229-7yoilsho	4690	20	:	:	:
cord-006229-7yoilsho	4690	21	ICAM-1	ICAM-1	NNP
cord-006229-7yoilsho	4690	22	,	,	,
cord-006229-7yoilsho	4690	23	VCAM-1	VCAM-1	NNP
cord-006229-7yoilsho	4690	24	,	,	,
cord-006229-7yoilsho	4690	25	E	E	NNP
cord-006229-7yoilsho	4690	26	-	-	NN
cord-006229-7yoilsho	4690	27	selectin	selectin	JJ
cord-006229-7yoilsho	4690	28	,	,	,
cord-006229-7yoilsho	4690	29	N	n	CD
cord-006229-7yoilsho	4690	30	-	-	HYPH
cord-006229-7yoilsho	4690	31	cadherin	cadherin	NN
cord-006229-7yoilsho	4690	32	,	,	,
cord-006229-7yoilsho	4690	33	and	and	CC
cord-006229-7yoilsho	4690	34	galectin-3	galectin-3	NNP
cord-006229-7yoilsho	4690	35	.	.	.
cord-006229-7yoilsho	4691	1	Moreover	moreover	RB
cord-006229-7yoilsho	4691	2	,	,	,
cord-006229-7yoilsho	4691	3	the	the	DT
cord-006229-7yoilsho	4691	4	chemokine	chemokine	NN
cord-006229-7yoilsho	4691	5	system	system	NN
cord-006229-7yoilsho	4691	6	CXCL12	CXCL12	NNP
cord-006229-7yoilsho	4691	7	/	/	SYM
cord-006229-7yoilsho	4691	8	CXCR4	CXCR4	NNP
cord-006229-7yoilsho	4691	9	was	be	VBD
cord-006229-7yoilsho	4691	10	analyzed	analyze	VBN
cord-006229-7yoilsho	4691	11	.	.	.
cord-006229-7yoilsho	4692	1	It	-PRON-	PRP
cord-006229-7yoilsho	4692	2	could	could	MD
cord-006229-7yoilsho	4692	3	be	be	VB
cord-006229-7yoilsho	4692	4	demonstrated	demonstrate	VBN
cord-006229-7yoilsho	4692	5	that	that	IN
cord-006229-7yoilsho	4692	6	the	the	DT
cord-006229-7yoilsho	4692	7	mRNA	mRNA	NNP
cord-006229-7yoilsho	4692	8	level	level	NN
cord-006229-7yoilsho	4692	9	of	of	IN
cord-006229-7yoilsho	4692	10	endothelial	endothelial	JJ
cord-006229-7yoilsho	4692	11	N	n	CD
cord-006229-7yoilsho	4692	12	-	-	HYPH
cord-006229-7yoilsho	4692	13	cadherin	cadherin	NN
cord-006229-7yoilsho	4692	14	is	be	VBZ
cord-006229-7yoilsho	4692	15	upregulated	upregulate	VBN
cord-006229-7yoilsho	4692	16	by	by	IN
cord-006229-7yoilsho	4692	17	PT	PT	NNP
cord-006229-7yoilsho	4692	18	.	.	.
cord-006229-7yoilsho	4693	1	While	while	IN
cord-006229-7yoilsho	4693	2	total	total	JJ
cord-006229-7yoilsho	4693	3	protein	protein	NN
cord-006229-7yoilsho	4693	4	expression	expression	NN
cord-006229-7yoilsho	4693	5	of	of	IN
cord-006229-7yoilsho	4693	6	Ncadherin	Ncadherin	NNP
cord-006229-7yoilsho	4693	7	was	be	VBD
cord-006229-7yoilsho	4693	8	enhanced	enhance	VBN
cord-006229-7yoilsho	4693	9	in	in	IN
cord-006229-7yoilsho	4693	10	PT	PT	NNP
cord-006229-7yoilsho	4693	11	treated	treat	VBD
cord-006229-7yoilsho	4693	12	HUVEC	HUVEC	NNP
cord-006229-7yoilsho	4693	13	,	,	,
cord-006229-7yoilsho	4693	14	its	-PRON-	PRP$
cord-006229-7yoilsho	4693	15	surface	surface	NN
cord-006229-7yoilsho	4693	16	expression	expression	NN
cord-006229-7yoilsho	4693	17	was	be	VBD
cord-006229-7yoilsho	4693	18	not	not	RB
cord-006229-7yoilsho	4693	19	largely	largely	RB
cord-006229-7yoilsho	4693	20	influenced	influence	VBN
cord-006229-7yoilsho	4693	21	by	by	IN
cord-006229-7yoilsho	4693	22	PT	PT	NNP
cord-006229-7yoilsho	4693	23	(	(	-LRB-
cord-006229-7yoilsho	4693	24	Western	western	JJ
cord-006229-7yoilsho	4693	25	blot	blot	NN
cord-006229-7yoilsho	4693	26	,	,	,
cord-006229-7yoilsho	4693	27	flow	flow	NN
cord-006229-7yoilsho	4693	28	cytometry	cytometry	NN
cord-006229-7yoilsho	4693	29	)	)	-RRB-
cord-006229-7yoilsho	4693	30	.	.	.
cord-006229-7yoilsho	4694	1	In	in	IN
cord-006229-7yoilsho	4694	2	line	line	NN
cord-006229-7yoilsho	4694	3	with	with	IN
cord-006229-7yoilsho	4694	4	this	this	DT
cord-006229-7yoilsho	4694	5	,	,	,
cord-006229-7yoilsho	4694	6	blocking	block	VBG
cord-006229-7yoilsho	4694	7	endothelial	endothelial	JJ
cord-006229-7yoilsho	4694	8	Ncadherin	Ncadherin	NNP
cord-006229-7yoilsho	4694	9	by	by	IN
cord-006229-7yoilsho	4694	10	a	a	DT
cord-006229-7yoilsho	4694	11	neutralizing	neutralize	VBG
cord-006229-7yoilsho	4694	12	antibody	antibody	NN
cord-006229-7yoilsho	4694	13	revealed	reveal	VBD
cord-006229-7yoilsho	4694	14	that	that	IN
cord-006229-7yoilsho	4694	15	this	this	DT
cord-006229-7yoilsho	4694	16	protein	protein	NN
cord-006229-7yoilsho	4694	17	is	be	VBZ
cord-006229-7yoilsho	4694	18	not	not	RB
cord-006229-7yoilsho	4694	19	involved	involve	VBN
cord-006229-7yoilsho	4694	20	in	in	IN
cord-006229-7yoilsho	4694	21	PTevoked	PTevoked	NNP
cord-006229-7yoilsho	4694	22	tumor	tumor	NN
cord-006229-7yoilsho	4694	23	cell	cell	NN
cord-006229-7yoilsho	4694	24	adhesion	adhesion	NN
cord-006229-7yoilsho	4694	25	.	.	.
cord-006229-7yoilsho	4695	1	Interestingly	interestingly	RB
cord-006229-7yoilsho	4695	2	,	,	,
cord-006229-7yoilsho	4695	3	PT	PT	NNP
cord-006229-7yoilsho	4695	4	strongly	strongly	RB
cord-006229-7yoilsho	4695	5	augmented	augment	VBD
cord-006229-7yoilsho	4695	6	the	the	DT
cord-006229-7yoilsho	4695	7	mRNA	mrna	NN
cord-006229-7yoilsho	4695	8	and	and	CC
cord-006229-7yoilsho	4695	9	protein	protein	NN
cord-006229-7yoilsho	4695	10	expression	expression	NN
cord-006229-7yoilsho	4695	11	of	of	IN
cord-006229-7yoilsho	4695	12	CXCL12	CXCL12	NNP
cord-006229-7yoilsho	4695	13	in	in	IN
cord-006229-7yoilsho	4695	14	HUVECs	HUVECs	NNP
cord-006229-7yoilsho	4695	15	(	(	-LRB-
cord-006229-7yoilsho	4695	16	qRT	qRT	NNP
cord-006229-7yoilsho	4695	17	-	-	HYPH
cord-006229-7yoilsho	4695	18	PCR	PCR	NNP
cord-006229-7yoilsho	4695	19	,	,	,
cord-006229-7yoilsho	4695	20	Western	western	JJ
cord-006229-7yoilsho	4695	21	blot	blot	NN
cord-006229-7yoilsho	4695	22	)	)	-RRB-
cord-006229-7yoilsho	4695	23	,	,	,
cord-006229-7yoilsho	4695	24	whereas	whereas	IN
cord-006229-7yoilsho	4695	25	its	-PRON-	PRP$
cord-006229-7yoilsho	4695	26	endothelial	endothelial	JJ
cord-006229-7yoilsho	4695	27	secretion	secretion	NN
cord-006229-7yoilsho	4695	28	was	be	VBD
cord-006229-7yoilsho	4695	29	not	not	RB
cord-006229-7yoilsho	4695	30	affected	affect	VBN
cord-006229-7yoilsho	4695	31	by	by	IN
cord-006229-7yoilsho	4695	32	PT	PT	NNP
cord-006229-7yoilsho	4695	33	(	(	-LRB-
cord-006229-7yoilsho	4695	34	ELISA	ELISA	NNP
cord-006229-7yoilsho	4695	35	)	)	-RRB-
cord-006229-7yoilsho	4695	36	.	.	.
cord-006229-7yoilsho	4696	1	An	an	DT
cord-006229-7yoilsho	4696	2	autocrine	autocrine	JJ
cord-006229-7yoilsho	4696	3	action	action	NN
cord-006229-7yoilsho	4696	4	of	of	IN
cord-006229-7yoilsho	4696	5	CXCL12	CXCL12	NNP
cord-006229-7yoilsho	4696	6	could	could	MD
cord-006229-7yoilsho	4696	7	be	be	VB
cord-006229-7yoilsho	4696	8	excluded	exclude	VBN
cord-006229-7yoilsho	4696	9	,	,	,
cord-006229-7yoilsho	4696	10	since	since	IN
cord-006229-7yoilsho	4696	11	blocking	block	VBG
cord-006229-7yoilsho	4696	12	the	the	DT
cord-006229-7yoilsho	4696	13	CXCL12	CXCL12	NNP
cord-006229-7yoilsho	4696	14	receptor	receptor	NN
cord-006229-7yoilsho	4696	15	CXCR4	CXCR4	NNS
cord-006229-7yoilsho	4696	16	on	on	IN
cord-006229-7yoilsho	4696	17	endothelial	endothelial	JJ
cord-006229-7yoilsho	4696	18	cells	cell	NNS
cord-006229-7yoilsho	4696	19	with	with	IN
cord-006229-7yoilsho	4696	20	plerixafor	plerixafor	NN
cord-006229-7yoilsho	4696	21	did	do	VBD
cord-006229-7yoilsho	4696	22	not	not	RB
cord-006229-7yoilsho	4696	23	influence	influence	VB
cord-006229-7yoilsho	4696	24	cancer	cancer	NN
cord-006229-7yoilsho	4696	25	cell	cell	NN
cord-006229-7yoilsho	4696	26	adhesion	adhesion	NN
cord-006229-7yoilsho	4696	27	.	.	.
cord-006229-7yoilsho	4697	1	By	by	IN
cord-006229-7yoilsho	4697	2	microscopic	microscopic	JJ
cord-006229-7yoilsho	4697	3	analyses	analysis	NNS
cord-006229-7yoilsho	4697	4	,	,	,
cord-006229-7yoilsho	4697	5	we	-PRON-	PRP
cord-006229-7yoilsho	4697	6	observed	observe	VBD
cord-006229-7yoilsho	4697	7	that	that	IN
cord-006229-7yoilsho	4697	8	PT	PT	NNP
cord-006229-7yoilsho	4697	9	treatment	treatment	NN
cord-006229-7yoilsho	4697	10	causes	cause	VBZ
cord-006229-7yoilsho	4697	11	transient	transient	JJ
cord-006229-7yoilsho	4697	12	gaps	gap	NNS
cord-006229-7yoilsho	4697	13	in	in	IN
cord-006229-7yoilsho	4697	14	the	the	DT
cord-006229-7yoilsho	4697	15	HUVEC	HUVEC	NNP
cord-006229-7yoilsho	4697	16	monolayer	monolayer	NN
cord-006229-7yoilsho	4697	17	,	,	,
cord-006229-7yoilsho	4697	18	where	where	WRB
cord-006229-7yoilsho	4697	19	tumor	tumor	NN
cord-006229-7yoilsho	4697	20	cells	cell	NNS
cord-006229-7yoilsho	4697	21	prefer	prefer	VBP
cord-006229-7yoilsho	4697	22	to	to	TO
cord-006229-7yoilsho	4697	23	adhere	adhere	VB
cord-006229-7yoilsho	4697	24	.	.	.
cord-006229-7yoilsho	4698	1	Since	since	IN
cord-006229-7yoilsho	4698	2	β1-integrins	β1-integrin	NNS
cord-006229-7yoilsho	4698	3	on	on	IN
cord-006229-7yoilsho	4698	4	the	the	DT
cord-006229-7yoilsho	4698	5	tumor	tumor	NN
cord-006229-7yoilsho	4698	6	cells	cell	NNS
cord-006229-7yoilsho	4698	7	could	could	MD
cord-006229-7yoilsho	4698	8	mediate	mediate	VB
cord-006229-7yoilsho	4698	9	interactions	interaction	NNS
cord-006229-7yoilsho	4698	10	between	between	IN
cord-006229-7yoilsho	4698	11	cancer	cancer	NN
cord-006229-7yoilsho	4698	12	cells	cell	NNS
cord-006229-7yoilsho	4698	13	and	and	CC
cord-006229-7yoilsho	4698	14	extracellular	extracellular	JJ
cord-006229-7yoilsho	4698	15	matrix	matrix	NN
cord-006229-7yoilsho	4698	16	proteins	protein	NNS
cord-006229-7yoilsho	4698	17	in	in	IN
cord-006229-7yoilsho	4698	18	the	the	DT
cord-006229-7yoilsho	4698	19	gaps	gap	NNS
cord-006229-7yoilsho	4698	20	(	(	-LRB-
cord-006229-7yoilsho	4698	21	e.g.	e.g.	RB
cord-006229-7yoilsho	4698	22	collagen	collagen	NNP
cord-006229-7yoilsho	4698	23	)	)	-RRB-
cord-006229-7yoilsho	4698	24	,	,	,
cord-006229-7yoilsho	4698	25	their	-PRON-	PRP$
cord-006229-7yoilsho	4698	26	influence	influence	NN
cord-006229-7yoilsho	4698	27	in	in	IN
cord-006229-7yoilsho	4698	28	cell	cell	NN
cord-006229-7yoilsho	4698	29	adhesion	adhesion	NN
cord-006229-7yoilsho	4698	30	and	and	CC
cord-006229-7yoilsho	4698	31	transmigration	transmigration	NN
cord-006229-7yoilsho	4698	32	assays	assay	NNS
cord-006229-7yoilsho	4698	33	was	be	VBD
cord-006229-7yoilsho	4698	34	examined	examine	VBN
cord-006229-7yoilsho	4698	35	.	.	.
cord-006229-7yoilsho	4699	1	Both	both	DT
cord-006229-7yoilsho	4699	2	the	the	DT
cord-006229-7yoilsho	4699	3	PT	pt	NN
cord-006229-7yoilsho	4699	4	-	-	HYPH
cord-006229-7yoilsho	4699	5	evoked	evoke	VBN
cord-006229-7yoilsho	4699	6	increase	increase	NN
cord-006229-7yoilsho	4699	7	in	in	IN
cord-006229-7yoilsho	4699	8	cell	cell	NN
cord-006229-7yoilsho	4699	9	adhesion	adhesion	NN
cord-006229-7yoilsho	4699	10	and	and	CC
cord-006229-7yoilsho	4699	11	decrease	decrease	NN
cord-006229-7yoilsho	4699	12	in	in	IN
cord-006229-7yoilsho	4699	13	transmigration	transmigration	NN
cord-006229-7yoilsho	4699	14	was	be	VBD
cord-006229-7yoilsho	4699	15	completely	completely	RB
cord-006229-7yoilsho	4699	16	abolished	abolish	VBN
cord-006229-7yoilsho	4699	17	when	when	WRB
cord-006229-7yoilsho	4699	18	β1-integrins	β1-integrin	NNS
cord-006229-7yoilsho	4699	19	were	be	VBD
cord-006229-7yoilsho	4699	20	blocked	block	VBN
cord-006229-7yoilsho	4699	21	on	on	IN
cord-006229-7yoilsho	4699	22	MDAs	mda	NNS
cord-006229-7yoilsho	4699	23	by	by	IN
cord-006229-7yoilsho	4699	24	a	a	DT
cord-006229-7yoilsho	4699	25	neutralizing	neutralize	VBG
cord-006229-7yoilsho	4699	26	antibody	antibody	NN
cord-006229-7yoilsho	4699	27	.	.	.
cord-006229-7yoilsho	4700	1	These	these	DT
cord-006229-7yoilsho	4700	2	results	result	NNS
cord-006229-7yoilsho	4700	3	indicate	indicate	VBP
cord-006229-7yoilsho	4700	4	that	that	IN
cord-006229-7yoilsho	4700	5	the	the	DT
cord-006229-7yoilsho	4700	6	anti	anti	JJ
cord-006229-7yoilsho	4700	7	-	-	JJ
cord-006229-7yoilsho	4700	8	metastatic	metastatic	JJ
cord-006229-7yoilsho	4700	9	action	action	NN
cord-006229-7yoilsho	4700	10	of	of	IN
cord-006229-7yoilsho	4700	11	pretubulysin	pretubulysin	NNP
cord-006229-7yoilsho	4700	12	might	may	MD
cord-006229-7yoilsho	4700	13	be	be	VB
cord-006229-7yoilsho	4700	14	based	base	VBN
cord-006229-7yoilsho	4700	15	on	on	IN
cord-006229-7yoilsho	4700	16	the	the	DT
cord-006229-7yoilsho	4700	17	trapping	trapping	NN
cord-006229-7yoilsho	4700	18	of	of	IN
cord-006229-7yoilsho	4700	19	tumor	tumor	NN
cord-006229-7yoilsho	4700	20	cells	cell	NNS
cord-006229-7yoilsho	4700	21	on	on	IN
cord-006229-7yoilsho	4700	22	the	the	DT
cord-006229-7yoilsho	4700	23	endothelium	endothelium	NN
cord-006229-7yoilsho	4700	24	.	.	.
cord-006229-7yoilsho	4701	1	Whether	whether	IN
cord-006229-7yoilsho	4701	2	this	this	DT
cord-006229-7yoilsho	4701	3	effect	effect	NN
cord-006229-7yoilsho	4701	4	is	be	VBZ
cord-006229-7yoilsho	4701	5	also	also	RB
cord-006229-7yoilsho	4701	6	relevant	relevant	JJ
cord-006229-7yoilsho	4701	7	in	in	IN
cord-006229-7yoilsho	4701	8	vivo	vivo	NN
cord-006229-7yoilsho	4701	9	,	,	,
cord-006229-7yoilsho	4701	10	will	will	MD
cord-006229-7yoilsho	4701	11	be	be	VB
cord-006229-7yoilsho	4701	12	analyzed	analyze	VBN
cord-006229-7yoilsho	4701	13	in	in	IN
cord-006229-7yoilsho	4701	14	future	future	JJ
cord-006229-7yoilsho	4701	15	studies	study	NNS
cord-006229-7yoilsho	4701	16	using	use	VBG
cord-006229-7yoilsho	4701	17	intravital	intravital	JJ
cord-006229-7yoilsho	4701	18	microscopy	microscopy	NNP
cord-006229-7yoilsho	4701	19	.	.	.
cord-006229-7yoilsho	4702	1	This	this	DT
cord-006229-7yoilsho	4702	2	work	work	NN
cord-006229-7yoilsho	4702	3	was	be	VBD
cord-006229-7yoilsho	4702	4	supported	support	VBN
cord-006229-7yoilsho	4702	5	by	by	IN
cord-006229-7yoilsho	4702	6	the	the	DT
cord-006229-7yoilsho	4702	7	German	German	NNP
cord-006229-7yoilsho	4702	8	Research	Research	NNP
cord-006229-7yoilsho	4702	9	Foundation	Foundation	NNP
cord-006229-7yoilsho	4702	10	(	(	-LRB-
cord-006229-7yoilsho	4702	11	DFG	DFG	NNP
cord-006229-7yoilsho	4702	12	,	,	,
cord-006229-7yoilsho	4702	13	FOR	for	IN
cord-006229-7yoilsho	4702	14	1406	1406	CD
cord-006229-7yoilsho	4702	15	,	,	,
cord-006229-7yoilsho	4702	16	FU	FU	NNP
cord-006229-7yoilsho	4702	17	691/9	691/9	CD
cord-006229-7yoilsho	4702	18	-	-	SYM
cord-006229-7yoilsho	4702	19	2	2	CD
cord-006229-7yoilsho	4702	20	)	)	-RRB-
cord-006229-7yoilsho	4702	21	.	.	.
cord-006229-7yoilsho	4703	1	Introduction	introduction	NN
cord-006229-7yoilsho	4703	2	:	:	:
cord-006229-7yoilsho	4704	1	Tyrosine	tyrosine	NN
cord-006229-7yoilsho	4704	2	kinase	kinase	NN
cord-006229-7yoilsho	4704	3	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	4704	4	(	(	-LRB-
cord-006229-7yoilsho	4704	5	TKIs	TKIs	NNP
cord-006229-7yoilsho	4704	6	)	)	-RRB-
cord-006229-7yoilsho	4704	7	for	for	IN
cord-006229-7yoilsho	4704	8	the	the	DT
cord-006229-7yoilsho	4704	9	treatment	treatment	NN
cord-006229-7yoilsho	4704	10	of	of	IN
cord-006229-7yoilsho	4704	11	non	non	JJ
cord-006229-7yoilsho	4704	12	-	-	JJ
cord-006229-7yoilsho	4704	13	small	small	JJ
cord-006229-7yoilsho	4704	14	cell	cell	NN
cord-006229-7yoilsho	4704	15	lung	lung	NN
cord-006229-7yoilsho	4704	16	cancer	cancer	NN
cord-006229-7yoilsho	4704	17	(	(	-LRB-
cord-006229-7yoilsho	4704	18	NSCLC	NSCLC	NNP
cord-006229-7yoilsho	4704	19	)	)	-RRB-
cord-006229-7yoilsho	4704	20	patients	patient	NNS
cord-006229-7yoilsho	4704	21	harboring	harbor	VBG
cord-006229-7yoilsho	4704	22	activating	activate	VBG
cord-006229-7yoilsho	4704	23	mutations	mutation	NNS
cord-006229-7yoilsho	4704	24	in	in	IN
cord-006229-7yoilsho	4704	25	the	the	DT
cord-006229-7yoilsho	4704	26	epidermal	epidermal	JJ
cord-006229-7yoilsho	4704	27	growth	growth	NN
cord-006229-7yoilsho	4704	28	factor	factor	NN
cord-006229-7yoilsho	4705	1	receptor	receptor	NN
cord-006229-7yoilsho	4705	2	have	have	VBP
cord-006229-7yoilsho	4705	3	shown	show	VBN
cord-006229-7yoilsho	4705	4	prominent	prominent	JJ
cord-006229-7yoilsho	4705	5	success	success	NN
cord-006229-7yoilsho	4705	6	.	.	.
cord-006229-7yoilsho	4706	1	Nevertheless	nevertheless	RB
cord-006229-7yoilsho	4706	2	,	,	,
cord-006229-7yoilsho	4706	3	patients	patient	NNS
cord-006229-7yoilsho	4706	4	treated	treat	VBN
cord-006229-7yoilsho	4706	5	with	with	IN
cord-006229-7yoilsho	4706	6	TKIs	tki	NNS
cord-006229-7yoilsho	4706	7	eventually	eventually	RB
cord-006229-7yoilsho	4706	8	acquire	acquire	VBP
cord-006229-7yoilsho	4706	9	resistance	resistance	NN
cord-006229-7yoilsho	4706	10	and	and	CC
cord-006229-7yoilsho	4706	11	relapse	relapse	NN
cord-006229-7yoilsho	4706	12	(	(	-LRB-
cord-006229-7yoilsho	4706	13	1	1	CD
cord-006229-7yoilsho	4706	14	)	)	-RRB-
cord-006229-7yoilsho	4706	15	.	.	.
cord-006229-7yoilsho	4707	1	Based	base	VBN
cord-006229-7yoilsho	4707	2	on	on	IN
cord-006229-7yoilsho	4707	3	an	an	DT
cord-006229-7yoilsho	4707	4	evolutionary	evolutionary	JJ
cord-006229-7yoilsho	4707	5	cancer	cancer	NN
cord-006229-7yoilsho	4707	6	model	model	NN
cord-006229-7yoilsho	4707	7	(	(	-LRB-
cord-006229-7yoilsho	4707	8	2	2	CD
cord-006229-7yoilsho	4707	9	)	)	-RRB-
cord-006229-7yoilsho	4707	10	,	,	,
cord-006229-7yoilsho	4707	11	weekly	weekly	JJ
cord-006229-7yoilsho	4707	12	high	high	JJ
cord-006229-7yoilsho	4707	13	dose	dose	NN
cord-006229-7yoilsho	4707	14	-	-	HYPH
cord-006229-7yoilsho	4707	15	pulsed	pulse	VBN
cord-006229-7yoilsho	4707	16	TKI	TKI	NNP
cord-006229-7yoilsho	4707	17	regimens	regimen	NNS
cord-006229-7yoilsho	4707	18	were	be	VBD
cord-006229-7yoilsho	4707	19	proposed	propose	VBN
cord-006229-7yoilsho	4707	20	to	to	TO
cord-006229-7yoilsho	4707	21	delay	delay	VB
cord-006229-7yoilsho	4707	22	resistance	resistance	NN
cord-006229-7yoilsho	4707	23	.	.	.
cord-006229-7yoilsho	4708	1	Using	use	VBG
cord-006229-7yoilsho	4708	2	data	datum	NNS
cord-006229-7yoilsho	4708	3	from	from	IN
cord-006229-7yoilsho	4708	4	NSCLC	NSCLC	NNP
cord-006229-7yoilsho	4708	5	bearing	bear	VBG
cord-006229-7yoilsho	4708	6	mice	mouse	NNS
cord-006229-7yoilsho	4708	7	treated	treat	VBN
cord-006229-7yoilsho	4708	8	with	with	IN
cord-006229-7yoilsho	4708	9	erlotinib	erlotinib	NN
cord-006229-7yoilsho	4708	10	at	at	IN
cord-006229-7yoilsho	4708	11	different	different	JJ
cord-006229-7yoilsho	4708	12	dosing	dosing	NN
cord-006229-7yoilsho	4708	13	regimens	regimen	NNS
cord-006229-7yoilsho	4708	14	,	,	,
cord-006229-7yoilsho	4708	15	we	-PRON-	PRP
cord-006229-7yoilsho	4708	16	developed	develop	VBD
cord-006229-7yoilsho	4708	17	a	a	DT
cord-006229-7yoilsho	4708	18	semi	semi	JJ
cord-006229-7yoilsho	4708	19	-	-	JJ
cord-006229-7yoilsho	4708	20	mechanistic	mechanistic	JJ
cord-006229-7yoilsho	4708	21	pharmacokinetic	pharmacokinetic	JJ
cord-006229-7yoilsho	4708	22	/	/	SYM
cord-006229-7yoilsho	4708	23	pharmacodynamic	pharmacodynamic	JJ
cord-006229-7yoilsho	4708	24	model	model	NN
cord-006229-7yoilsho	4708	25	for	for	IN
cord-006229-7yoilsho	4708	26	erlotinib	erlotinib	NN
cord-006229-7yoilsho	4708	27	effects	effect	NNS
cord-006229-7yoilsho	4708	28	on	on	IN
cord-006229-7yoilsho	4708	29	tumor	tumor	NN
cord-006229-7yoilsho	4708	30	killing	killing	NN
cord-006229-7yoilsho	4708	31	and	and	CC
cord-006229-7yoilsho	4708	32	resistance	resistance	NN
cord-006229-7yoilsho	4708	33	development	development	NN
cord-006229-7yoilsho	4708	34	.	.	.
cord-006229-7yoilsho	4709	1	Methods	method	NNS
cord-006229-7yoilsho	4709	2	:	:	:
cord-006229-7yoilsho	4710	1	Data	datum	NNS
cord-006229-7yoilsho	4710	2	was	be	VBD
cord-006229-7yoilsho	4710	3	available	available	JJ
cord-006229-7yoilsho	4710	4	from	from	IN
cord-006229-7yoilsho	4710	5	experiments	experiment	NNS
cord-006229-7yoilsho	4710	6	in	in	IN
cord-006229-7yoilsho	4710	7	xenograft	xenograft	NN
cord-006229-7yoilsho	4710	8	mice	mouse	NNS
cord-006229-7yoilsho	4710	9	bearing	bear	VBG
cord-006229-7yoilsho	4710	10	NSCLC	nsclc	JJ
cord-006229-7yoilsho	4710	11	tumors	tumor	NNS
cord-006229-7yoilsho	4710	12	(	(	-LRB-
cord-006229-7yoilsho	4710	13	PC9	PC9	NNP
cord-006229-7yoilsho	4710	14	and	and	CC
cord-006229-7yoilsho	4710	15	HCC827	HCC827	NNP
cord-006229-7yoilsho	4710	16	cell	cell	NN
cord-006229-7yoilsho	4710	17	lines	line	NNS
cord-006229-7yoilsho	4710	18	;	;	:
cord-006229-7yoilsho	4710	19	both	both	CC
cord-006229-7yoilsho	4710	20	erlotinib	erlotinib	NN
cord-006229-7yoilsho	4710	21	sensitive	sensitive	JJ
cord-006229-7yoilsho	4710	22	)	)	-RRB-
cord-006229-7yoilsho	4710	23	(	(	-LRB-
cord-006229-7yoilsho	4710	24	3	3	CD
cord-006229-7yoilsho	4710	25	)	)	-RRB-
cord-006229-7yoilsho	4710	26	.	.	.
cord-006229-7yoilsho	4711	1	Plasma	plasma	NN
cord-006229-7yoilsho	4711	2	concentrations	concentration	NNS
cord-006229-7yoilsho	4711	3	from	from	IN
cord-006229-7yoilsho	4711	4	two	two	CD
cord-006229-7yoilsho	4711	5	single	single	JJ
cord-006229-7yoilsho	4711	6	-	-	HYPH
cord-006229-7yoilsho	4711	7	dose	dose	NN
cord-006229-7yoilsho	4711	8	groups	group	NNS
cord-006229-7yoilsho	4711	9	,	,	,
cord-006229-7yoilsho	4711	10	30mg	30mg	NN
cord-006229-7yoilsho	4711	11	/	/	SYM
cord-006229-7yoilsho	4711	12	kg	kg	NN
cord-006229-7yoilsho	4711	13	and	and	CC
cord-006229-7yoilsho	4711	14	200mg	200mg	NNP
cord-006229-7yoilsho	4711	15	/	/	SYM
cord-006229-7yoilsho	4711	16	kg	kg	NNS
cord-006229-7yoilsho	4711	17	,	,	,
cord-006229-7yoilsho	4711	18	were	be	VBD
cord-006229-7yoilsho	4711	19	used	use	VBN
cord-006229-7yoilsho	4711	20	for	for	IN
cord-006229-7yoilsho	4711	21	pharmacokinetic	pharmacokinetic	JJ
cord-006229-7yoilsho	4711	22	modeling	modeling	NN
cord-006229-7yoilsho	4711	23	.	.	.
cord-006229-7yoilsho	4712	1	Relative	relative	JJ
cord-006229-7yoilsho	4712	2	tumor	tumor	NN
cord-006229-7yoilsho	4712	3	volume	volume	NN
cord-006229-7yoilsho	4712	4	changes	change	NNS
cord-006229-7yoilsho	4712	5	in	in	IN
cord-006229-7yoilsho	4712	6	mice	mouse	NNS
cord-006229-7yoilsho	4712	7	randomized	randomize	VBN
cord-006229-7yoilsho	4712	8	to	to	IN
cord-006229-7yoilsho	4712	9	five	five	CD
cord-006229-7yoilsho	4712	10	dosing	dose	VBG
cord-006229-7yoilsho	4712	11	regimens	regimen	NNS
cord-006229-7yoilsho	4712	12	(	(	-LRB-
cord-006229-7yoilsho	4713	1	15mg	15mg	NNP
cord-006229-7yoilsho	4713	2	/	/	SYM
cord-006229-7yoilsho	4713	3	kg	kg	NNP
cord-006229-7yoilsho	4713	4	daily	daily	RB
cord-006229-7yoilsho	4713	5	,	,	,
cord-006229-7yoilsho	4713	6	30mg	30mg	NNP
cord-006229-7yoilsho	4713	7	/	/	SYM
cord-006229-7yoilsho	4713	8	kg	kg	NNP
cord-006229-7yoilsho	4713	9	daily	daily	NN
cord-006229-7yoilsho	4713	10	,	,	,
cord-006229-7yoilsho	4713	11	200mg	200mg	NNP
cord-006229-7yoilsho	4713	12	/	/	SYM
cord-006229-7yoilsho	4713	13	kg	kg	NNP
cord-006229-7yoilsho	4714	1	every	every	DT
cord-006229-7yoilsho	4714	2	2	2	CD
cord-006229-7yoilsho	4714	3	days	day	NNS
cord-006229-7yoilsho	4714	4	,	,	,
cord-006229-7yoilsho	4714	5	200mg	200mg	NNP
cord-006229-7yoilsho	4714	6	/	/	SYM
cord-006229-7yoilsho	4714	7	kg	kg	NN
cord-006229-7yoilsho	4714	8	every	every	DT
cord-006229-7yoilsho	4714	9	4	4	CD
cord-006229-7yoilsho	4714	10	days	day	NNS
cord-006229-7yoilsho	4714	11	,	,	,
cord-006229-7yoilsho	4714	12	or	or	CC
cord-006229-7yoilsho	4714	13	vehicle	vehicle	NN
cord-006229-7yoilsho	4714	14	)	)	-RRB-
cord-006229-7yoilsho	4714	15	was	be	VBD
cord-006229-7yoilsho	4714	16	the	the	DT
cord-006229-7yoilsho	4714	17	pharmacodynamic	pharmacodynamic	JJ
cord-006229-7yoilsho	4714	18	endpoint	endpoint	NN
cord-006229-7yoilsho	4714	19	.	.	.
cord-006229-7yoilsho	4715	1	A	a	DT
cord-006229-7yoilsho	4715	2	tumor	tumor	NN
cord-006229-7yoilsho	4715	3	growth	growth	NN
cord-006229-7yoilsho	4715	4	inhibition	inhibition	NN
cord-006229-7yoilsho	4715	5	model	model	NN
cord-006229-7yoilsho	4715	6	was	be	VBD
cord-006229-7yoilsho	4715	7	developed	develop	VBN
cord-006229-7yoilsho	4715	8	by	by	IN
cord-006229-7yoilsho	4715	9	testing	test	VBG
cord-006229-7yoilsho	4715	10	linear	linear	JJ
cord-006229-7yoilsho	4715	11	,	,	,
cord-006229-7yoilsho	4715	12	exponential	exponential	JJ
cord-006229-7yoilsho	4715	13	and	and	CC
cord-006229-7yoilsho	4715	14	logistic	logistic	JJ
cord-006229-7yoilsho	4715	15	models	model	NNS
cord-006229-7yoilsho	4715	16	to	to	TO
cord-006229-7yoilsho	4715	17	account	account	VB
cord-006229-7yoilsho	4715	18	for	for	IN
cord-006229-7yoilsho	4715	19	the	the	DT
cord-006229-7yoilsho	4715	20	tumor	tumor	NN
cord-006229-7yoilsho	4715	21	growth	growth	NN
cord-006229-7yoilsho	4715	22	kinetics	kinetic	NNS
cord-006229-7yoilsho	4715	23	,	,	,
cord-006229-7yoilsho	4715	24	as	as	RB
cord-006229-7yoilsho	4715	25	well	well	RB
cord-006229-7yoilsho	4715	26	as	as	IN
cord-006229-7yoilsho	4715	27	fitting	fit	VBG
cord-006229-7yoilsho	4715	28	an	an	DT
cord-006229-7yoilsho	4715	29	Emax	Emax	NNP
cord-006229-7yoilsho	4715	30	model	model	NN
cord-006229-7yoilsho	4715	31	to	to	TO
cord-006229-7yoilsho	4715	32	explain	explain	VB
cord-006229-7yoilsho	4715	33	the	the	DT
cord-006229-7yoilsho	4715	34	effect	effect	NN
cord-006229-7yoilsho	4715	35	of	of	IN
cord-006229-7yoilsho	4715	36	exposure	exposure	NN
cord-006229-7yoilsho	4715	37	on	on	IN
cord-006229-7yoilsho	4715	38	killing	kill	VBG
cord-006229-7yoilsho	4715	39	the	the	DT
cord-006229-7yoilsho	4715	40	sensitive	sensitive	JJ
cord-006229-7yoilsho	4715	41	tumor	tumor	NN
cord-006229-7yoilsho	4715	42	cells	cell	NNS
cord-006229-7yoilsho	4715	43	,	,	,
cord-006229-7yoilsho	4715	44	and	and	CC
cord-006229-7yoilsho	4715	45	resistance	resistance	NN
cord-006229-7yoilsho	4715	46	development	development	NN
cord-006229-7yoilsho	4715	47	.	.	.
cord-006229-7yoilsho	4716	1	Analysis	analysis	NN
cord-006229-7yoilsho	4716	2	was	be	VBD
cord-006229-7yoilsho	4716	3	performed	perform	VBN
cord-006229-7yoilsho	4716	4	using	use	VBG
cord-006229-7yoilsho	4716	5	NONMEM	NONMEM	NNP
cord-006229-7yoilsho	4716	6	7.3	7.3	CD
cord-006229-7yoilsho	4716	7	.	.	.
cord-006229-7yoilsho	4717	1	Results	result	NNS
cord-006229-7yoilsho	4717	2	:	:	:
cord-006229-7yoilsho	4718	1	Absorption	absorption	NN
cord-006229-7yoilsho	4718	2	was	be	VBD
cord-006229-7yoilsho	4718	3	dose	dose	JJ
cord-006229-7yoilsho	4718	4	dependent	dependent	JJ
cord-006229-7yoilsho	4718	5	,	,	,
cord-006229-7yoilsho	4718	6	and	and	CC
cord-006229-7yoilsho	4718	7	a	a	DT
cord-006229-7yoilsho	4718	8	precipitate	precipitate	NN
cord-006229-7yoilsho	4718	9	compartment	compartment	NN
cord-006229-7yoilsho	4718	10	accounted	account	VBD
cord-006229-7yoilsho	4718	11	for	for	IN
cord-006229-7yoilsho	4718	12	dissolution	dissolution	NN
cord-006229-7yoilsho	4718	13	limited	limit	VBN
cord-006229-7yoilsho	4718	14	absorption	absorption	NN
cord-006229-7yoilsho	4718	15	for	for	IN
cord-006229-7yoilsho	4718	16	the	the	DT
cord-006229-7yoilsho	4718	17	200mg	200mg	NNP
cord-006229-7yoilsho	4718	18	/	/	SYM
cord-006229-7yoilsho	4718	19	kg	kg	NN
cord-006229-7yoilsho	4718	20	dose	dose	NN
cord-006229-7yoilsho	4718	21	.	.	.
cord-006229-7yoilsho	4719	1	A	a	DT
cord-006229-7yoilsho	4719	2	1-compartment	1-compartment	CD
cord-006229-7yoilsho	4719	3	model	model	NN
cord-006229-7yoilsho	4719	4	with	with	IN
cord-006229-7yoilsho	4719	5	first	first	JJ
cord-006229-7yoilsho	4719	6	order	order	NN
cord-006229-7yoilsho	4719	7	elimination	elimination	NN
cord-006229-7yoilsho	4719	8	kinetics	kinetic	NNS
cord-006229-7yoilsho	4719	9	described	describe	VBD
cord-006229-7yoilsho	4719	10	distribution	distribution	NN
cord-006229-7yoilsho	4719	11	and	and	CC
cord-006229-7yoilsho	4719	12	elimination	elimination	NN
cord-006229-7yoilsho	4719	13	.	.	.
cord-006229-7yoilsho	4720	1	To	to	TO
cord-006229-7yoilsho	4720	2	describe	describe	VB
cord-006229-7yoilsho	4720	3	tumor	tumor	NN
cord-006229-7yoilsho	4720	4	volume	volume	NN
cord-006229-7yoilsho	4720	5	changes	change	NNS
cord-006229-7yoilsho	4720	6	,	,	,
cord-006229-7yoilsho	4720	7	a	a	DT
cord-006229-7yoilsho	4720	8	tumor	tumor	NN
cord-006229-7yoilsho	4720	9	was	be	VBD
cord-006229-7yoilsho	4720	10	assumed	assume	VBN
cord-006229-7yoilsho	4720	11	to	to	TO
cord-006229-7yoilsho	4720	12	be	be	VB
cord-006229-7yoilsho	4720	13	a	a	DT
cord-006229-7yoilsho	4720	14	mixture	mixture	NN
cord-006229-7yoilsho	4720	15	of	of	IN
cord-006229-7yoilsho	4720	16	sensitive	sensitive	JJ
cord-006229-7yoilsho	4720	17	and	and	CC
cord-006229-7yoilsho	4720	18	resistant	resistant	JJ
cord-006229-7yoilsho	4720	19	cells	cell	NNS
cord-006229-7yoilsho	4720	20	(	(	-LRB-
cord-006229-7yoilsho	4720	21	represented	represent	VBN
cord-006229-7yoilsho	4720	22	by	by	IN
cord-006229-7yoilsho	4720	23	distinct	distinct	JJ
cord-006229-7yoilsho	4720	24	compartments	compartment	NNS
cord-006229-7yoilsho	4720	25	and	and	CC
cord-006229-7yoilsho	4720	26	ordinary	ordinary	JJ
cord-006229-7yoilsho	4720	27	differential	differential	JJ
cord-006229-7yoilsho	4720	28	equations	equation	NNS
cord-006229-7yoilsho	4720	29	)	)	-RRB-
cord-006229-7yoilsho	4720	30	.	.	.
cord-006229-7yoilsho	4721	1	Exponential	exponential	JJ
cord-006229-7yoilsho	4721	2	kinetics	kinetic	NNS
cord-006229-7yoilsho	4721	3	best	best	RB
cord-006229-7yoilsho	4721	4	described	describe	VBD
cord-006229-7yoilsho	4721	5	natural	natural	JJ
cord-006229-7yoilsho	4721	6	growth	growth	NN
cord-006229-7yoilsho	4721	7	(	(	-LRB-
cord-006229-7yoilsho	4721	8	doubling	double	VBG
cord-006229-7yoilsho	4721	9	times	time	NNS
cord-006229-7yoilsho	4721	10	:	:	:
cord-006229-7yoilsho	4721	11	13	13	CD
cord-006229-7yoilsho	4721	12	and	and	CC
cord-006229-7yoilsho	4721	13	52	52	CD
cord-006229-7yoilsho	4721	14	days	day	NNS
cord-006229-7yoilsho	4721	15	,	,	,
cord-006229-7yoilsho	4721	16	for	for	IN
cord-006229-7yoilsho	4721	17	sensitive	sensitive	JJ
cord-006229-7yoilsho	4721	18	and	and	CC
cord-006229-7yoilsho	4721	19	fully	fully	RB
cord-006229-7yoilsho	4721	20	resistant	resistant	JJ
cord-006229-7yoilsho	4721	21	cells	cell	NNS
cord-006229-7yoilsho	4721	22	,	,	,
cord-006229-7yoilsho	4721	23	respectively	respectively	RB
cord-006229-7yoilsho	4721	24	)	)	-RRB-
cord-006229-7yoilsho	4721	25	.	.	.
cord-006229-7yoilsho	4722	1	A	a	DT
cord-006229-7yoilsho	4722	2	tumor	tumor	NN
cord-006229-7yoilsho	4722	3	was	be	VBD
cord-006229-7yoilsho	4722	4	found	find	VBN
cord-006229-7yoilsho	4722	5	to	to	TO
cord-006229-7yoilsho	4722	6	transit	transit	VB
cord-006229-7yoilsho	4722	7	through	through	IN
cord-006229-7yoilsho	4722	8	a	a	DT
cord-006229-7yoilsho	4722	9	less	less	RBR
cord-006229-7yoilsho	4722	10	sensitive	sensitive	JJ
cord-006229-7yoilsho	4722	11	phase	phase	NN
cord-006229-7yoilsho	4722	12	before	before	IN
cord-006229-7yoilsho	4722	13	acquiring	acquire	VBG
cord-006229-7yoilsho	4722	14	full	full	JJ
cord-006229-7yoilsho	4722	15	resistance	resistance	NN
cord-006229-7yoilsho	4722	16	.	.	.
cord-006229-7yoilsho	4723	1	An	an	DT
cord-006229-7yoilsho	4723	2	E	e	NN
cord-006229-7yoilsho	4723	3	max	max	NN
cord-006229-7yoilsho	4723	4	model	model	NN
cord-006229-7yoilsho	4723	5	(	(	-LRB-
cord-006229-7yoilsho	4723	6	less	less	JJR
cord-006229-7yoilsho	4723	7	than	than	IN
cord-006229-7yoilsho	4723	8	linear	linear	NNP
cord-006229-7yoilsho	4723	9	)	)	-RRB-
cord-006229-7yoilsho	4723	10	best	best	RB
cord-006229-7yoilsho	4723	11	described	describe	VBN
cord-006229-7yoilsho	4723	12	effect	effect	NN
cord-006229-7yoilsho	4723	13	on	on	IN
cord-006229-7yoilsho	4723	14	the	the	DT
cord-006229-7yoilsho	4723	15	sensitive	sensitive	JJ
cord-006229-7yoilsho	4723	16	cells	cell	NNS
cord-006229-7yoilsho	4723	17	(	(	-LRB-
cord-006229-7yoilsho	4723	18	EC	EC	NNP
cord-006229-7yoilsho	4723	19	50	50	CD
cord-006229-7yoilsho	4723	20	=	=	SYM
cord-006229-7yoilsho	4723	21	0.53μM	0.53μm	CD
cord-006229-7yoilsho	4723	22	for	for	IN
cord-006229-7yoilsho	4723	23	both	both	DT
cord-006229-7yoilsho	4723	24	cell	cell	NN
cord-006229-7yoilsho	4723	25	lines	line	NNS
cord-006229-7yoilsho	4723	26	)	)	-RRB-
cord-006229-7yoilsho	4723	27	,	,	,
cord-006229-7yoilsho	4723	28	and	and	CC
cord-006229-7yoilsho	4723	29	on	on	IN
cord-006229-7yoilsho	4723	30	the	the	DT
cord-006229-7yoilsho	4723	31	partially	partially	RB
cord-006229-7yoilsho	4723	32	sensitive	sensitive	JJ
cord-006229-7yoilsho	4723	33	transit	transit	NN
cord-006229-7yoilsho	4723	34	phase	phase	NN
cord-006229-7yoilsho	4723	35	(	(	-LRB-
cord-006229-7yoilsho	4723	36	EC	EC	NNP
cord-006229-7yoilsho	4723	37	50	50	CD
cord-006229-7yoilsho	4723	38	=	=	SYM
cord-006229-7yoilsho	4723	39	1.24μM	1.24μm	CD
cord-006229-7yoilsho	4723	40	and	and	CC
cord-006229-7yoilsho	4723	41	3.00μM	3.00μm	CD
cord-006229-7yoilsho	4723	42	,	,	,
cord-006229-7yoilsho	4723	43	for	for	IN
cord-006229-7yoilsho	4723	44	HCC827	HCC827	NNP
cord-006229-7yoilsho	4723	45	and	and	CC
cord-006229-7yoilsho	4723	46	PC9	PC9	NNP
cord-006229-7yoilsho	4723	47	cell	cell	NN
cord-006229-7yoilsho	4723	48	lines	line	NNS
cord-006229-7yoilsho	4723	49	,	,	,
cord-006229-7yoilsho	4723	50	respectively	respectively	RB
cord-006229-7yoilsho	4723	51	)	)	-RRB-
cord-006229-7yoilsho	4723	52	,	,	,
cord-006229-7yoilsho	4723	53	urging	urge	VBG
cord-006229-7yoilsho	4723	54	to	to	TO
cord-006229-7yoilsho	4723	55	provide	provide	VB
cord-006229-7yoilsho	4723	56	adequate	adequate	JJ
cord-006229-7yoilsho	4723	57	trough	trough	NN
cord-006229-7yoilsho	4723	58	erlotinib	erlotinib	NN
cord-006229-7yoilsho	4723	59	concentrations	concentration	NNS
cord-006229-7yoilsho	4723	60	for	for	IN
cord-006229-7yoilsho	4723	61	optimal	optimal	JJ
cord-006229-7yoilsho	4723	62	effects	effect	NNS
cord-006229-7yoilsho	4723	63	.	.	.
cord-006229-7yoilsho	4724	1	Conclusions	conclusion	NNS
cord-006229-7yoilsho	4724	2	&	&	CC
cord-006229-7yoilsho	4724	3	future	future	JJ
cord-006229-7yoilsho	4724	4	perspectives	perspective	NNS
cord-006229-7yoilsho	4724	5	:	:	:
cord-006229-7yoilsho	4725	1	An	an	DT
cord-006229-7yoilsho	4725	2	exposure	exposure	NN
cord-006229-7yoilsho	4725	3	-	-	HYPH
cord-006229-7yoilsho	4725	4	driven	drive	VBN
cord-006229-7yoilsho	4725	5	tumor	tumor	NN
cord-006229-7yoilsho	4725	6	growth	growth	NN
cord-006229-7yoilsho	4725	7	inhibition	inhibition	NN
cord-006229-7yoilsho	4725	8	model	model	NN
cord-006229-7yoilsho	4725	9	accounting	account	VBG
cord-006229-7yoilsho	4725	10	for	for	IN
cord-006229-7yoilsho	4725	11	the	the	DT
cord-006229-7yoilsho	4725	12	kinetics	kinetic	NNS
cord-006229-7yoilsho	4725	13	of	of	IN
cord-006229-7yoilsho	4725	14	resistance	resistance	NN
cord-006229-7yoilsho	4725	15	development	development	NN
cord-006229-7yoilsho	4725	16	was	be	VBD
cord-006229-7yoilsho	4725	17	developed	develop	VBN
cord-006229-7yoilsho	4725	18	.	.	.
cord-006229-7yoilsho	4726	1	The	the	DT
cord-006229-7yoilsho	4726	2	model	model	NN
cord-006229-7yoilsho	4726	3	emphasizes	emphasize	VBZ
cord-006229-7yoilsho	4726	4	the	the	DT
cord-006229-7yoilsho	4726	5	need	need	NN
cord-006229-7yoilsho	4726	6	for	for	IN
cord-006229-7yoilsho	4726	7	establishing	establish	VBG
cord-006229-7yoilsho	4726	8	an	an	DT
cord-006229-7yoilsho	4726	9	adequate	adequate	JJ
cord-006229-7yoilsho	4726	10	trough	trough	NN
cord-006229-7yoilsho	4726	11	erlotinib	erlotinib	NN
cord-006229-7yoilsho	4726	12	concentrations	concentration	NNS
cord-006229-7yoilsho	4726	13	to	to	TO
cord-006229-7yoilsho	4726	14	delay	delay	VB
cord-006229-7yoilsho	4726	15	disease	disease	NN
cord-006229-7yoilsho	4726	16	progression	progression	NN
cord-006229-7yoilsho	4726	17	.	.	.
cord-006229-7yoilsho	4727	1	Extracts	extract	NNS
cord-006229-7yoilsho	4727	2	of	of	IN
cord-006229-7yoilsho	4727	3	the	the	DT
cord-006229-7yoilsho	4727	4	stem	stem	NN
cord-006229-7yoilsho	4727	5	bark	bark	NN
cord-006229-7yoilsho	4727	6	of	of	IN
cord-006229-7yoilsho	4727	7	Ficus	Ficus	NNP
cord-006229-7yoilsho	4727	8	platyphylla	platyphylla	NNP
cord-006229-7yoilsho	4727	9	(	(	-LRB-
cord-006229-7yoilsho	4727	10	FP	FP	NNP
cord-006229-7yoilsho	4727	11	)	)	-RRB-
cord-006229-7yoilsho	4727	12	have	have	VBP
cord-006229-7yoilsho	4727	13	been	be	VBN
cord-006229-7yoilsho	4727	14	used	use	VBN
cord-006229-7yoilsho	4727	15	in	in	IN
cord-006229-7yoilsho	4727	16	traditional	traditional	JJ
cord-006229-7yoilsho	4727	17	Nigerian	nigerian	JJ
cord-006229-7yoilsho	4727	18	medicine	medicine	NN
cord-006229-7yoilsho	4727	19	to	to	TO
cord-006229-7yoilsho	4727	20	treat	treat	VB
cord-006229-7yoilsho	4727	21	psychoses	psychosis	NNS
cord-006229-7yoilsho	4727	22	,	,	,
cord-006229-7yoilsho	4727	23	depression	depression	NN
cord-006229-7yoilsho	4727	24	,	,	,
cord-006229-7yoilsho	4727	25	epilepsy	epilepsy	NN
cord-006229-7yoilsho	4727	26	,	,	,
cord-006229-7yoilsho	4727	27	pain	pain	NN
cord-006229-7yoilsho	4727	28	and	and	CC
cord-006229-7yoilsho	4727	29	inflammation	inflammation	NN
cord-006229-7yoilsho	4727	30	.	.	.
cord-006229-7yoilsho	4728	1	Previous	previous	JJ
cord-006229-7yoilsho	4728	2	studies	study	NNS
cord-006229-7yoilsho	4728	3	have	have	VBP
cord-006229-7yoilsho	4728	4	revealed	reveal	VBN
cord-006229-7yoilsho	4728	5	the	the	DT
cord-006229-7yoilsho	4728	6	analgesic	analgesic	JJ
cord-006229-7yoilsho	4728	7	and	and	CC
cord-006229-7yoilsho	4728	8	anti	anti	JJ
cord-006229-7yoilsho	4728	9	-	-	JJ
cord-006229-7yoilsho	4728	10	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	4728	11	effects	effect	NNS
cord-006229-7yoilsho	4728	12	of	of	IN
cord-006229-7yoilsho	4728	13	FP	FP	NNP
cord-006229-7yoilsho	4728	14	in	in	IN
cord-006229-7yoilsho	4728	15	different	different	JJ
cord-006229-7yoilsho	4728	16	assays	assay	NNS
cord-006229-7yoilsho	4728	17	including	include	VBG
cord-006229-7yoilsho	4728	18	acetic	acetic	JJ
cord-006229-7yoilsho	4728	19	acid	acid	NN
cord-006229-7yoilsho	4728	20	-	-	HYPH
cord-006229-7yoilsho	4728	21	induced	induce	VBN
cord-006229-7yoilsho	4728	22	writhing	writhing	NN
cord-006229-7yoilsho	4728	23	,	,	,
cord-006229-7yoilsho	4728	24	formalin	formalin	NN
cord-006229-7yoilsho	4728	25	-	-	HYPH
cord-006229-7yoilsho	4728	26	induced	induce	VBN
cord-006229-7yoilsho	4728	27	nociception	nociception	NN
cord-006229-7yoilsho	4728	28	,	,	,
cord-006229-7yoilsho	4728	29	and	and	CC
cord-006229-7yoilsho	4728	30	albumin	albumin	NN
cord-006229-7yoilsho	4728	31	-	-	HYPH
cord-006229-7yoilsho	4728	32	induced	induce	VBN
cord-006229-7yoilsho	4728	33	oedema	oedema	NN
cord-006229-7yoilsho	4728	34	.	.	.
cord-006229-7yoilsho	4729	1	In	in	IN
cord-006229-7yoilsho	4729	2	this	this	DT
cord-006229-7yoilsho	4729	3	study	study	NN
cord-006229-7yoilsho	4729	4	,	,	,
cord-006229-7yoilsho	4729	5	we	-PRON-	PRP
cord-006229-7yoilsho	4729	6	assessed	assess	VBD
cord-006229-7yoilsho	4729	7	the	the	DT
cord-006229-7yoilsho	4729	8	effects	effect	NNS
cord-006229-7yoilsho	4729	9	of	of	IN
cord-006229-7yoilsho	4729	10	the	the	DT
cord-006229-7yoilsho	4729	11	standardised	standardised	JJ
cord-006229-7yoilsho	4729	12	extract	extract	NN
cord-006229-7yoilsho	4729	13	of	of	IN
cord-006229-7yoilsho	4729	14	FP	FP	NNP
cord-006229-7yoilsho	4729	15	on	on	IN
cord-006229-7yoilsho	4729	16	hot	hot	JJ
cord-006229-7yoilsho	4729	17	plate	plate	NN
cord-006229-7yoilsho	4729	18	nociceptive	nociceptive	JJ
cord-006229-7yoilsho	4729	19	threshold	threshold	NN
cord-006229-7yoilsho	4729	20	and	and	CC
cord-006229-7yoilsho	4729	21	vocalisation	vocalisation	NN
cord-006229-7yoilsho	4729	22	threshold	threshold	NN
cord-006229-7yoilsho	4729	23	in	in	IN
cord-006229-7yoilsho	4729	24	response	response	NN
cord-006229-7yoilsho	4729	25	to	to	IN
cord-006229-7yoilsho	4729	26	electrical	electrical	JJ
cord-006229-7yoilsho	4729	27	stimulation	stimulation	NN
cord-006229-7yoilsho	4729	28	of	of	IN
cord-006229-7yoilsho	4729	29	the	the	DT
cord-006229-7yoilsho	4729	30	tail	tail	NN
cord-006229-7yoilsho	4729	31	root	root	NN
cord-006229-7yoilsho	4729	32	in	in	IN
cord-006229-7yoilsho	4729	33	order	order	NN
cord-006229-7yoilsho	4729	34	to	to	TO
cord-006229-7yoilsho	4729	35	confirm	confirm	VB
cord-006229-7yoilsho	4729	36	its	-PRON-	PRP$
cord-006229-7yoilsho	4729	37	acclaimed	acclaimed	JJ
cord-006229-7yoilsho	4729	38	analgesic	analgesic	JJ
cord-006229-7yoilsho	4729	39	properties	property	NNS
cord-006229-7yoilsho	4729	40	.	.	.
cord-006229-7yoilsho	4730	1	We	-PRON-	PRP
cord-006229-7yoilsho	4730	2	also	also	RB
cord-006229-7yoilsho	4730	3	investigated	investigate	VBD
cord-006229-7yoilsho	4730	4	the	the	DT
cord-006229-7yoilsho	4730	5	molecular	molecular	JJ
cord-006229-7yoilsho	4730	6	mechanisms	mechanism	NNS
cord-006229-7yoilsho	4730	7	underlying	underlie	VBG
cord-006229-7yoilsho	4730	8	these	these	DT
cord-006229-7yoilsho	4730	9	effects	effect	NNS
cord-006229-7yoilsho	4730	10	,	,	,
cord-006229-7yoilsho	4730	11	with	with	IN
cord-006229-7yoilsho	4730	12	the	the	DT
cord-006229-7yoilsho	4730	13	focus	focus	NN
cord-006229-7yoilsho	4730	14	on	on	IN
cord-006229-7yoilsho	4730	15	opiate	opiate	JJ
cord-006229-7yoilsho	4730	16	receptor	receptor	NN
cord-006229-7yoilsho	4730	17	binding	binding	NN
cord-006229-7yoilsho	4730	18	and	and	CC
cord-006229-7yoilsho	4730	19	the	the	DT
cord-006229-7yoilsho	4730	20	key	key	JJ
cord-006229-7yoilsho	4730	21	enzymes	enzyme	NNS
cord-006229-7yoilsho	4730	22	of	of	IN
cord-006229-7yoilsho	4730	23	eicosanoid	eicosanoid	NNP
cord-006229-7yoilsho	4730	24	biosynthesis	biosynthesis	NN
cord-006229-7yoilsho	4730	25	,	,	,
cord-006229-7yoilsho	4730	26	namely	namely	RB
cord-006229-7yoilsho	4730	27	cyclooxygenase	cyclooxygenase	JJ
cord-006229-7yoilsho	4730	28	(	(	-LRB-
cord-006229-7yoilsho	4730	29	COX	COX	NNP
cord-006229-7yoilsho	4730	30	)	)	-RRB-
cord-006229-7yoilsho	4730	31	and	and	CC
cord-006229-7yoilsho	4730	32	5-lipoxygenase	5-lipoxygenase	CD
cord-006229-7yoilsho	4730	33	(	(	-LRB-
cord-006229-7yoilsho	4730	34	5-LO	5-lo	CD
cord-006229-7yoilsho	4730	35	)	)	-RRB-
cord-006229-7yoilsho	4730	36	.	.	.
cord-006229-7yoilsho	4731	1	FP	FP	NNP
cord-006229-7yoilsho	4731	2	(	(	-LRB-
cord-006229-7yoilsho	4731	3	i	i	NN
cord-006229-7yoilsho	4731	4	)	)	-RRB-
cord-006229-7yoilsho	4731	5	increased	increase	VBD
cord-006229-7yoilsho	4731	6	the	the	DT
cord-006229-7yoilsho	4731	7	hot	hot	JJ
cord-006229-7yoilsho	4731	8	plate	plate	NN
cord-006229-7yoilsho	4731	9	nociceptive	nociceptive	JJ
cord-006229-7yoilsho	4731	10	threshold	threshold	NN
cord-006229-7yoilsho	4731	11	and	and	CC
cord-006229-7yoilsho	4731	12	vocalisation	vocalisation	NN
cord-006229-7yoilsho	4731	13	threshold	threshold	NN
cord-006229-7yoilsho	4731	14	.	.	.
cord-006229-7yoilsho	4732	1	The	the	DT
cord-006229-7yoilsho	4732	2	increase	increase	NN
cord-006229-7yoilsho	4732	3	in	in	IN
cord-006229-7yoilsho	4732	4	hot	hot	JJ
cord-006229-7yoilsho	4732	5	plate	plate	NN
cord-006229-7yoilsho	4732	6	nociceptive	nociceptive	JJ
cord-006229-7yoilsho	4732	7	threshold	threshold	NN
cord-006229-7yoilsho	4732	8	was	be	VBD
cord-006229-7yoilsho	4732	9	detectable	detectable	JJ
cord-006229-7yoilsho	4732	10	over	over	IN
cord-006229-7yoilsho	4732	11	a	a	DT
cord-006229-7yoilsho	4732	12	period	period	NN
cord-006229-7yoilsho	4732	13	of	of	IN
cord-006229-7yoilsho	4732	14	30	30	CD
cord-006229-7yoilsho	4732	15	min	min	NN
cord-006229-7yoilsho	4732	16	whereas	whereas	IN
cord-006229-7yoilsho	4732	17	the	the	DT
cord-006229-7yoilsho	4732	18	increase	increase	NN
cord-006229-7yoilsho	4732	19	in	in	IN
cord-006229-7yoilsho	4732	20	vocalisation	vocalisation	NN
cord-006229-7yoilsho	4732	21	threshold	threshold	NN
cord-006229-7yoilsho	4732	22	persisted	persist	VBD
cord-006229-7yoilsho	4732	23	over	over	IN
cord-006229-7yoilsho	4732	24	a	a	DT
cord-006229-7yoilsho	4732	25	period	period	NN
cord-006229-7yoilsho	4732	26	of	of	IN
cord-006229-7yoilsho	4732	27	90	90	CD
cord-006229-7yoilsho	4732	28	min	min	NN
cord-006229-7yoilsho	4732	29	.	.	.
cord-006229-7yoilsho	4733	1	(	(	-LRB-
cord-006229-7yoilsho	4733	2	ii	ii	LS
cord-006229-7yoilsho	4733	3	)	)	-RRB-
cord-006229-7yoilsho	4733	4	FP	FP	NNP
cord-006229-7yoilsho	4733	5	showed	show	VBD
cord-006229-7yoilsho	4733	6	an	an	DT
cord-006229-7yoilsho	4733	7	affinity	affinity	NN
cord-006229-7yoilsho	4733	8	for	for	IN
cord-006229-7yoilsho	4733	9	µ	µ	NN
cord-006229-7yoilsho	4733	10	opiate	opiate	NN
cord-006229-7yoilsho	4733	11	receptors	receptor	NNS
cord-006229-7yoilsho	4733	12	but	but	CC
cord-006229-7yoilsho	4733	13	not	not	RB
cord-006229-7yoilsho	4733	14	for	for	IN
cord-006229-7yoilsho	4733	15	δ	δ	NN
cord-006229-7yoilsho	4733	16	or	or	CC
cord-006229-7yoilsho	4733	17	κ	κ	NN
cord-006229-7yoilsho	4733	18	opiate	opiate	NN
cord-006229-7yoilsho	4733	19	receptors	receptor	NNS
cord-006229-7yoilsho	4733	20	,	,	,
cord-006229-7yoilsho	4733	21	and	and	CC
cord-006229-7yoilsho	4734	1	(	(	-LRB-
cord-006229-7yoilsho	4734	2	iii	iii	NN
cord-006229-7yoilsho	4734	3	)	)	-RRB-
cord-006229-7yoilsho	4734	4	FP	FP	NNP
cord-006229-7yoilsho	4734	5	inhibited	inhibit	VBD
cord-006229-7yoilsho	4734	6	the	the	DT
cord-006229-7yoilsho	4734	7	activities	activity	NNS
cord-006229-7yoilsho	4734	8	of	of	IN
cord-006229-7yoilsho	4734	9	COX-2	COX-2	NNP
cord-006229-7yoilsho	4734	10	and	and	CC
cord-006229-7yoilsho	4734	11	5-LO	5-lo	CD
cord-006229-7yoilsho	4734	12	but	but	CC
cord-006229-7yoilsho	4734	13	not	not	RB
cord-006229-7yoilsho	4734	14	of	of	IN
cord-006229-7yoilsho	4734	15	COX-1	cox-1	NN
cord-006229-7yoilsho	4734	16	.	.	.
cord-006229-7yoilsho	4735	1	We	-PRON-	PRP
cord-006229-7yoilsho	4735	2	provided	provide	VBD
cord-006229-7yoilsho	4735	3	evidence	evidence	NN
cord-006229-7yoilsho	4735	4	supporting	support	VBG
cord-006229-7yoilsho	4735	5	the	the	DT
cord-006229-7yoilsho	4735	6	use	use	NN
cord-006229-7yoilsho	4735	7	of	of	IN
cord-006229-7yoilsho	4735	8	FP	FP	NNP
cord-006229-7yoilsho	4735	9	in	in	IN
cord-006229-7yoilsho	4735	10	Nigerian	nigerian	JJ
cord-006229-7yoilsho	4735	11	folk	folk	NN
cord-006229-7yoilsho	4735	12	medicine	medicine	NN
cord-006229-7yoilsho	4735	13	for	for	IN
cord-006229-7yoilsho	4735	14	the	the	DT
cord-006229-7yoilsho	4735	15	treatment	treatment	NN
cord-006229-7yoilsho	4735	16	of	of	IN
cord-006229-7yoilsho	4735	17	different	different	JJ
cord-006229-7yoilsho	4735	18	types	type	NNS
cord-006229-7yoilsho	4735	19	of	of	IN
cord-006229-7yoilsho	4735	20	pain	pain	NN
cord-006229-7yoilsho	4735	21	,	,	,
cord-006229-7yoilsho	4735	22	and	and	CC
cord-006229-7yoilsho	4735	23	identified	identify	VBN
cord-006229-7yoilsho	4735	24	opioid	opioid	JJ
cord-006229-7yoilsho	4735	25	and	and	CC
cord-006229-7yoilsho	4735	26	non	non	JJ
cord-006229-7yoilsho	4735	27	-	-	JJ
cord-006229-7yoilsho	4735	28	opioid	opioid	JJ
cord-006229-7yoilsho	4735	29	targets	target	NNS
cord-006229-7yoilsho	4735	30	.	.	.
cord-006229-7yoilsho	4736	1	It	-PRON-	PRP
cord-006229-7yoilsho	4736	2	is	be	VBZ
cord-006229-7yoilsho	4736	3	interesting	interesting	JJ
cord-006229-7yoilsho	4736	4	to	to	TO
cord-006229-7yoilsho	4736	5	note	note	VB
cord-006229-7yoilsho	4736	6	that	that	IN
cord-006229-7yoilsho	4736	7	the	the	DT
cord-006229-7yoilsho	4736	8	dual	dual	JJ
cord-006229-7yoilsho	4736	9	inhibition	inhibition	NN
cord-006229-7yoilsho	4736	10	of	of	IN
cord-006229-7yoilsho	4736	11	COX-2	COX-2	NNP
cord-006229-7yoilsho	4736	12	and	and	CC
cord-006229-7yoilsho	4736	13	5-LO	5-lo	CD
cord-006229-7yoilsho	4736	14	appears	appear	VBZ
cord-006229-7yoilsho	4736	15	favourable	favourable	JJ
cord-006229-7yoilsho	4736	16	in	in	IN
cord-006229-7yoilsho	4736	17	terms	term	NNS
cord-006229-7yoilsho	4736	18	of	of	IN
cord-006229-7yoilsho	4736	19	both	both	DT
cord-006229-7yoilsho	4736	20	efficacy	efficacy	NN
cord-006229-7yoilsho	4736	21	and	and	CC
cord-006229-7yoilsho	4736	22	side	side	NN
cord-006229-7yoilsho	4736	23	effect	effect	NN
cord-006229-7yoilsho	4736	24	profile	profile	NN
cord-006229-7yoilsho	4736	25	.	.	.
cord-006229-7yoilsho	4737	1	Despite	despite	IN
cord-006229-7yoilsho	4737	2	the	the	DT
cord-006229-7yoilsho	4737	3	fact	fact	NN
cord-006229-7yoilsho	4737	4	,	,	,
cord-006229-7yoilsho	4737	5	that	that	IN
cord-006229-7yoilsho	4737	6	the	the	DT
cord-006229-7yoilsho	4737	7	enormous	enormous	JJ
cord-006229-7yoilsho	4737	8	economic	economic	JJ
cord-006229-7yoilsho	4737	9	burden	burden	NN
cord-006229-7yoilsho	4737	10	and	and	CC
cord-006229-7yoilsho	4737	11	individual	individual	JJ
cord-006229-7yoilsho	4737	12	suffering	suffering	NN
cord-006229-7yoilsho	4737	13	caused	cause	VBN
cord-006229-7yoilsho	4737	14	by	by	IN
cord-006229-7yoilsho	4737	15	gastrointestinal	gastrointestinal	JJ
cord-006229-7yoilsho	4737	16	infections	infection	NNS
cord-006229-7yoilsho	4737	17	permanently	permanently	RB
cord-006229-7yoilsho	4737	18	persists	persist	VBZ
cord-006229-7yoilsho	4737	19	in	in	IN
cord-006229-7yoilsho	4737	20	developing	develop	VBG
cord-006229-7yoilsho	4737	21	and	and	CC
cord-006229-7yoilsho	4737	22	newly	newly	RB
cord-006229-7yoilsho	4737	23	industrialized	industrialize	VBN
cord-006229-7yoilsho	4737	24	countries	country	NNS
cord-006229-7yoilsho	4737	25	,	,	,
cord-006229-7yoilsho	4737	26	healthcare	healthcare	NN
cord-006229-7yoilsho	4737	27	systems	system	NNS
cord-006229-7yoilsho	4737	28	in	in	IN
cord-006229-7yoilsho	4737	29	First	first	JJ
cord-006229-7yoilsho	4737	30	world	world	NN
cord-006229-7yoilsho	4737	31	countries	country	NNS
cord-006229-7yoilsho	4737	32	underestimated	underestimate	VBD
cord-006229-7yoilsho	4737	33	its	-PRON-	PRP$
cord-006229-7yoilsho	4737	34	significance	significance	NN
cord-006229-7yoilsho	4737	35	for	for	IN
cord-006229-7yoilsho	4737	36	a	a	DT
cord-006229-7yoilsho	4737	37	long	long	JJ
cord-006229-7yoilsho	4737	38	time	time	NN
cord-006229-7yoilsho	4737	39	.	.	.
cord-006229-7yoilsho	4738	1	The	the	DT
cord-006229-7yoilsho	4738	2	alarming	alarming	JJ
cord-006229-7yoilsho	4738	3	prevalence	prevalence	NN
cord-006229-7yoilsho	4738	4	of	of	IN
cord-006229-7yoilsho	4738	5	multidrug	multidrug	NN
cord-006229-7yoilsho	4738	6	-	-	HYPH
cord-006229-7yoilsho	4738	7	resistant	resistant	JJ
cord-006229-7yoilsho	4738	8	gram	gram	NN
cord-006229-7yoilsho	4738	9	-	-	HYPH
cord-006229-7yoilsho	4738	10	negative	negative	JJ
cord-006229-7yoilsho	4738	11	bacteria	bacteria	NNS
cord-006229-7yoilsho	4738	12	,	,	,
cord-006229-7yoilsho	4738	13	combined	combine	VBN
cord-006229-7yoilsho	4738	14	with	with	IN
cord-006229-7yoilsho	4738	15	a	a	DT
cord-006229-7yoilsho	4738	16	high	high	JJ
cord-006229-7yoilsho	4738	17	epidemic	epidemic	NN
cord-006229-7yoilsho	4738	18	potential	potential	NN
cord-006229-7yoilsho	4738	19	of	of	IN
cord-006229-7yoilsho	4738	20	gastrointestinal	gastrointestinal	JJ
cord-006229-7yoilsho	4738	21	pathogens	pathogen	NNS
cord-006229-7yoilsho	4738	22	,	,	,
cord-006229-7yoilsho	4738	23	however	however	RB
cord-006229-7yoilsho	4738	24	,	,	,
cord-006229-7yoilsho	4738	25	demonstrates	demonstrate	VBZ
cord-006229-7yoilsho	4738	26	the	the	DT
cord-006229-7yoilsho	4738	27	urgent	urgent	JJ
cord-006229-7yoilsho	4738	28	need	need	NN
cord-006229-7yoilsho	4738	29	for	for	IN
cord-006229-7yoilsho	4738	30	new	new	JJ
cord-006229-7yoilsho	4738	31	antibiotics	antibiotic	NNS
cord-006229-7yoilsho	4738	32	and	and	CC
cord-006229-7yoilsho	4738	33	antiinfectives	antiinfective	NNS
cord-006229-7yoilsho	4738	34	worldwide	worldwide	RB
cord-006229-7yoilsho	4738	35	.	.	.
cord-006229-7yoilsho	4739	1	2,5	2,5	CD
cord-006229-7yoilsho	4739	2	million	million	CD
cord-006229-7yoilsho	4739	3	deaths	death	NNS
cord-006229-7yoilsho	4739	4	per	per	IN
cord-006229-7yoilsho	4739	5	year	year	NN
cord-006229-7yoilsho	4739	6	were	be	VBD
cord-006229-7yoilsho	4739	7	actually	actually	RB
cord-006229-7yoilsho	4739	8	caused	cause	VBN
cord-006229-7yoilsho	4739	9	by	by	IN
cord-006229-7yoilsho	4739	10	acute	acute	JJ
cord-006229-7yoilsho	4739	11	diarrheal	diarrheal	JJ
cord-006229-7yoilsho	4739	12	infections	infection	NNS
cord-006229-7yoilsho	4739	13	.	.	.
cord-006229-7yoilsho	4740	1	The	the	DT
cord-006229-7yoilsho	4740	2	most	most	RBS
cord-006229-7yoilsho	4740	3	common	common	JJ
cord-006229-7yoilsho	4740	4	causative	causative	JJ
cord-006229-7yoilsho	4740	5	agents	agent	NNS
cord-006229-7yoilsho	4740	6	of	of	IN
cord-006229-7yoilsho	4740	7	acute	acute	JJ
cord-006229-7yoilsho	4740	8	diarrheal	diarrheal	JJ
cord-006229-7yoilsho	4740	9	infections	infection	NNS
cord-006229-7yoilsho	4740	10	,	,	,
cord-006229-7yoilsho	4740	11	amongst	amongst	IN
cord-006229-7yoilsho	4740	12	others	other	NNS
cord-006229-7yoilsho	4740	13	,	,	,
cord-006229-7yoilsho	4740	14	are	be	VBP
cord-006229-7yoilsho	4740	15	Yersinia	Yersinia	NNP
cord-006229-7yoilsho	4740	16	enterocolitica	enterocolitica	NNP
cord-006229-7yoilsho	4740	17	,	,	,
cord-006229-7yoilsho	4740	18	Campylobacter	Campylobacter	NNP
cord-006229-7yoilsho	4740	19	jejuni	jejuni	NNP
cord-006229-7yoilsho	4740	20	,	,	,
cord-006229-7yoilsho	4740	21	Salmonella	salmonella	NN
cord-006229-7yoilsho	4740	22	spp	spp	NNS
cord-006229-7yoilsho	4740	23	.	.	.
cord-006229-7yoilsho	4741	1	,	,	,
cord-006229-7yoilsho	4741	2	Shigella	Shigella	NNP
cord-006229-7yoilsho	4741	3	spp	spp	NNS
cord-006229-7yoilsho	4741	4	.	.	.
cord-006229-7yoilsho	4742	1	,	,	,
cord-006229-7yoilsho	4742	2	Escherichia	Escherichia	NNP
cord-006229-7yoilsho	4742	3	coli	coli	NNS
cord-006229-7yoilsho	4742	4	,	,	,
cord-006229-7yoilsho	4742	5	Vibrio	Vibrio	NNP
cord-006229-7yoilsho	4742	6	cholerae	cholerae	NN
cord-006229-7yoilsho	4742	7	,	,	,
cord-006229-7yoilsho	4742	8	and	and	CC
cord-006229-7yoilsho	4742	9	Clostridium	clostridium	NN
cord-006229-7yoilsho	4742	10	difficile	difficile	NN
cord-006229-7yoilsho	4742	11	.	.	.
cord-006229-7yoilsho	4743	1	The	the	DT
cord-006229-7yoilsho	4743	2	established	establish	VBN
cord-006229-7yoilsho	4743	3	treatment	treatment	NN
cord-006229-7yoilsho	4743	4	based	base	VBN
cord-006229-7yoilsho	4743	5	on	on	IN
cord-006229-7yoilsho	4743	6	antibiotics	antibiotic	NNS
cord-006229-7yoilsho	4743	7	is	be	VBZ
cord-006229-7yoilsho	4743	8	mostly	mostly	RB
cord-006229-7yoilsho	4743	9	ineffective	ineffective	JJ
cord-006229-7yoilsho	4743	10	or	or	CC
cord-006229-7yoilsho	4743	11	may	may	MD
cord-006229-7yoilsho	4743	12	even	even	RB
cord-006229-7yoilsho	4743	13	have	have	VB
cord-006229-7yoilsho	4743	14	adverse	adverse	JJ
cord-006229-7yoilsho	4743	15	side	side	NN
cord-006229-7yoilsho	4743	16	effects	effect	NNS
cord-006229-7yoilsho	4743	17	and	and	CC
cord-006229-7yoilsho	4743	18	result	result	VBP
cord-006229-7yoilsho	4743	19	in	in	IN
cord-006229-7yoilsho	4743	20	prolonged	prolong	VBN
cord-006229-7yoilsho	4743	21	shedding	shedding	NN
cord-006229-7yoilsho	4743	22	.	.	.
cord-006229-7yoilsho	4744	1	In	in	IN
cord-006229-7yoilsho	4744	2	either	either	DT
cord-006229-7yoilsho	4744	3	way	way	NN
cord-006229-7yoilsho	4744	4	,	,	,
cord-006229-7yoilsho	4744	5	antibiotic	antibiotic	JJ
cord-006229-7yoilsho	4744	6	treatment	treatment	NN
cord-006229-7yoilsho	4744	7	also	also	RB
cord-006229-7yoilsho	4744	8	eradicates	eradicate	VBZ
cord-006229-7yoilsho	4744	9	at	at	IN
cord-006229-7yoilsho	4744	10	least	least	JJS
cord-006229-7yoilsho	4744	11	parts	part	NNS
cord-006229-7yoilsho	4744	12	of	of	IN
cord-006229-7yoilsho	4744	13	the	the	DT
cord-006229-7yoilsho	4744	14	intestinal	intestinal	JJ
cord-006229-7yoilsho	4744	15	microbiome	microbiome	NN
cord-006229-7yoilsho	4744	16	,	,	,
cord-006229-7yoilsho	4744	17	and	and	CC
cord-006229-7yoilsho	4744	18	thereby	thereby	RB
cord-006229-7yoilsho	4744	19	disrupts	disrupt	VBZ
cord-006229-7yoilsho	4744	20	colonization	colonization	NN
cord-006229-7yoilsho	4744	21	resistance	resistance	NN
cord-006229-7yoilsho	4744	22	,	,	,
cord-006229-7yoilsho	4744	23	fosters	foster	VBZ
cord-006229-7yoilsho	4744	24	overgrowth	overgrowth	NN
cord-006229-7yoilsho	4744	25	of	of	IN
cord-006229-7yoilsho	4744	26	pathogens	pathogen	NNS
cord-006229-7yoilsho	4744	27	and	and	CC
cord-006229-7yoilsho	4744	28	prolongs	prolong	VBZ
cord-006229-7yoilsho	4744	29	shedding	shed	VBG
cord-006229-7yoilsho	4744	30	times	time	NNS
cord-006229-7yoilsho	4744	31	.	.	.
cord-006229-7yoilsho	4745	1	Therefore	therefore	RB
cord-006229-7yoilsho	4745	2	,	,	,
cord-006229-7yoilsho	4745	3	the	the	DT
cord-006229-7yoilsho	4745	4	development	development	NN
cord-006229-7yoilsho	4745	5	of	of	IN
cord-006229-7yoilsho	4745	6	future	future	JJ
cord-006229-7yoilsho	4745	7	drugs	drug	NNS
cord-006229-7yoilsho	4745	8	should	should	MD
cord-006229-7yoilsho	4745	9	be	be	VB
cord-006229-7yoilsho	4745	10	focused	focus	VBN
cord-006229-7yoilsho	4745	11	on	on	IN
cord-006229-7yoilsho	4745	12	highly	highly	RB
cord-006229-7yoilsho	4745	13	specific	specific	JJ
cord-006229-7yoilsho	4745	14	antiinfectives	antiinfective	NNS
cord-006229-7yoilsho	4745	15	,	,	,
cord-006229-7yoilsho	4745	16	which	which	WDT
cord-006229-7yoilsho	4745	17	enable	enable	VBP
cord-006229-7yoilsho	4745	18	a	a	DT
cord-006229-7yoilsho	4745	19	direct	direct	JJ
cord-006229-7yoilsho	4745	20	pathogenspecific	pathogenspecific	NN
cord-006229-7yoilsho	4745	21	treatment	treatment	NN
cord-006229-7yoilsho	4745	22	.	.	.
cord-006229-7yoilsho	4746	1	One	one	CD
cord-006229-7yoilsho	4746	2	very	very	RB
cord-006229-7yoilsho	4746	3	promising	promising	JJ
cord-006229-7yoilsho	4746	4	strategy	strategy	NN
cord-006229-7yoilsho	4746	5	is	be	VBZ
cord-006229-7yoilsho	4746	6	the	the	DT
cord-006229-7yoilsho	4746	7	inhibition	inhibition	NN
cord-006229-7yoilsho	4746	8	of	of	IN
cord-006229-7yoilsho	4746	9	the	the	DT
cord-006229-7yoilsho	4746	10	biogenesis	biogenesis	NN
cord-006229-7yoilsho	4746	11	of	of	IN
cord-006229-7yoilsho	4746	12	outer	outer	JJ
cord-006229-7yoilsho	4746	13	membrane	membrane	NN
cord-006229-7yoilsho	4746	14	virulence	virulence	NN
cord-006229-7yoilsho	4746	15	factors	factor	NNS
cord-006229-7yoilsho	4746	16	.	.	.
cord-006229-7yoilsho	4747	1	Due	due	IN
cord-006229-7yoilsho	4747	2	to	to	IN
cord-006229-7yoilsho	4747	3	the	the	DT
cord-006229-7yoilsho	4747	4	fact	fact	NN
cord-006229-7yoilsho	4747	5	that	that	IN
cord-006229-7yoilsho	4747	6	many	many	JJ
cord-006229-7yoilsho	4747	7	decisive	decisive	JJ
cord-006229-7yoilsho	4747	8	virulenceassociated	virulenceassociate	VBN
cord-006229-7yoilsho	4747	9	outer	outer	JJ
cord-006229-7yoilsho	4747	10	membrane	membrane	NN
cord-006229-7yoilsho	4747	11	proteins	protein	NNS
cord-006229-7yoilsho	4747	12	(	(	-LRB-
cord-006229-7yoilsho	4747	13	OMPs	OMPs	NNP
cord-006229-7yoilsho	4747	14	)	)	-RRB-
cord-006229-7yoilsho	4747	15	of	of	IN
cord-006229-7yoilsho	4747	16	gram	gram	JJ
cord-006229-7yoilsho	4747	17	-	-	HYPH
cord-006229-7yoilsho	4747	18	negative	negative	JJ
cord-006229-7yoilsho	4747	19	enteropathogens	enteropathogen	NNS
cord-006229-7yoilsho	4747	20	are	be	VBP
cord-006229-7yoilsho	4747	21	substrates	substrate	NNS
cord-006229-7yoilsho	4747	22	of	of	IN
cord-006229-7yoilsho	4747	23	the	the	DT
cord-006229-7yoilsho	4747	24	periplasmic	periplasmic	JJ
cord-006229-7yoilsho	4747	25	chaperone	chaperone	NN
cord-006229-7yoilsho	4747	26	SurA	SurA	NNP
cord-006229-7yoilsho	4747	27	exclusively	exclusively	RB
cord-006229-7yoilsho	4747	28	,	,	,
cord-006229-7yoilsho	4747	29	we	-PRON-	PRP
cord-006229-7yoilsho	4747	30	developed	develop	VBD
cord-006229-7yoilsho	4747	31	a	a	DT
cord-006229-7yoilsho	4747	32	new	new	JJ
cord-006229-7yoilsho	4747	33	assay	assay	NN
cord-006229-7yoilsho	4747	34	format	format	NN
cord-006229-7yoilsho	4747	35	to	to	TO
cord-006229-7yoilsho	4747	36	determine	determine	VB
cord-006229-7yoilsho	4747	37	SurA	SurA	NNP
cord-006229-7yoilsho	4747	38	in	in	IN
cord-006229-7yoilsho	4747	39	vitro	vitro	FW
cord-006229-7yoilsho	4747	40	chaperone	chaperone	NN
cord-006229-7yoilsho	4747	41	activity	activity	NN
cord-006229-7yoilsho	4747	42	.	.	.
cord-006229-7yoilsho	4748	1	Previous	previous	JJ
cord-006229-7yoilsho	4748	2	publications	publication	NNS
cord-006229-7yoilsho	4748	3	by	by	IN
cord-006229-7yoilsho	4748	4	Behrens	Behrens	NNP
cord-006229-7yoilsho	4748	5	et	et	NNP
cord-006229-7yoilsho	4748	6	al	al	NNP
cord-006229-7yoilsho	4748	7	.	.	.
cord-006229-7yoilsho	4749	1	,	,	,
cord-006229-7yoilsho	4749	2	2001	2001	CD
cord-006229-7yoilsho	4749	3	and	and	CC
cord-006229-7yoilsho	4749	4	Buchner	Buchner	NNP
cord-006229-7yoilsho	4749	5	et	et	NNP
cord-006229-7yoilsho	4749	6	al	al	NNP
cord-006229-7yoilsho	4749	7	.	.	.
cord-006229-7yoilsho	4750	1	,	,	,
cord-006229-7yoilsho	4750	2	1998	1998	CD
cord-006229-7yoilsho	4750	3	documented	document	VBD
cord-006229-7yoilsho	4750	4	an	an	DT
cord-006229-7yoilsho	4750	5	assay	assay	NN
cord-006229-7yoilsho	4750	6	to	to	TO
cord-006229-7yoilsho	4750	7	determine	determine	VB
cord-006229-7yoilsho	4750	8	SurA	SurA	NNP
cord-006229-7yoilsho	4750	9	in	in	IN
cord-006229-7yoilsho	4750	10	vitro	vitro	FW
cord-006229-7yoilsho	4750	11	chaperone	chaperone	NN
cord-006229-7yoilsho	4750	12	activity	activity	NN
cord-006229-7yoilsho	4750	13	with	with	IN
cord-006229-7yoilsho	4750	14	extremely	extremely	RB
cord-006229-7yoilsho	4750	15	limited	limited	JJ
cord-006229-7yoilsho	4750	16	sensitivity	sensitivity	NN
cord-006229-7yoilsho	4750	17	and	and	CC
cord-006229-7yoilsho	4750	18	minimal	minimal	JJ
cord-006229-7yoilsho	4750	19	detectable	detectable	JJ
cord-006229-7yoilsho	4750	20	concentration	concentration	NN
cord-006229-7yoilsho	4750	21	,	,	,
cord-006229-7yoilsho	4750	22	which	which	WDT
cord-006229-7yoilsho	4750	23	was	be	VBD
cord-006229-7yoilsho	4750	24	not	not	RB
cord-006229-7yoilsho	4750	25	suitable	suitable	JJ
cord-006229-7yoilsho	4750	26	for	for	IN
cord-006229-7yoilsho	4750	27	high	high	JJ
cord-006229-7yoilsho	4750	28	throughput	throughput	NN
cord-006229-7yoilsho	4750	29	screening	screening	NN
cord-006229-7yoilsho	4750	30	(	(	-LRB-
cord-006229-7yoilsho	4750	31	HTS	HTS	NNP
cord-006229-7yoilsho	4750	32	)	)	-RRB-
cord-006229-7yoilsho	4750	33	.	.	.
cord-006229-7yoilsho	4751	1	We	-PRON-	PRP
cord-006229-7yoilsho	4751	2	now	now	RB
cord-006229-7yoilsho	4751	3	developed	develop	VBD
cord-006229-7yoilsho	4751	4	a	a	DT
cord-006229-7yoilsho	4751	5	luciferase	luciferase	NN
cord-006229-7yoilsho	4751	6	-	-	HYPH
cord-006229-7yoilsho	4751	7	based	base	VBN
cord-006229-7yoilsho	4751	8	screening	screening	NN
cord-006229-7yoilsho	4751	9	assay	assay	NN
cord-006229-7yoilsho	4751	10	.	.	.
cord-006229-7yoilsho	4752	1	This	this	DT
cord-006229-7yoilsho	4752	2	highly	highly	RB
cord-006229-7yoilsho	4752	3	sensitive	sensitive	JJ
cord-006229-7yoilsho	4752	4	and	and	CC
cord-006229-7yoilsho	4752	5	robust	robust	JJ
cord-006229-7yoilsho	4752	6	test	test	NN
cord-006229-7yoilsho	4752	7	system	system	NN
cord-006229-7yoilsho	4752	8	has	have	VBZ
cord-006229-7yoilsho	4752	9	been	be	VBN
cord-006229-7yoilsho	4752	10	validated	validate	VBN
cord-006229-7yoilsho	4752	11	extensively	extensively	RB
cord-006229-7yoilsho	4752	12	and	and	CC
cord-006229-7yoilsho	4752	13	now	now	RB
cord-006229-7yoilsho	4752	14	gives	give	VBZ
cord-006229-7yoilsho	4752	15	reliable	reliable	JJ
cord-006229-7yoilsho	4752	16	output	output	NN
cord-006229-7yoilsho	4752	17	with	with	IN
cord-006229-7yoilsho	4752	18	an	an	DT
cord-006229-7yoilsho	4752	19	appreciable	appreciable	JJ
cord-006229-7yoilsho	4752	20	z	z	NN
cord-006229-7yoilsho	4752	21	-	-	HYPH
cord-006229-7yoilsho	4752	22	factor	factor	NN
cord-006229-7yoilsho	4752	23	of	of	IN
cord-006229-7yoilsho	4752	24	>	>	XX
cord-006229-7yoilsho	4752	25	0,6	0,6	XX
cord-006229-7yoilsho	4752	26	.	.	.
cord-006229-7yoilsho	4753	1	In	in	IN
cord-006229-7yoilsho	4753	2	cooperation	cooperation	NN
cord-006229-7yoilsho	4753	3	with	with	IN
cord-006229-7yoilsho	4753	4	the	the	DT
cord-006229-7yoilsho	4753	5	HZI	HZI	NNP
cord-006229-7yoilsho	4753	6	Braunschweig	Braunschweig	NNP
cord-006229-7yoilsho	4753	7	(	(	-LRB-
cord-006229-7yoilsho	4753	8	Germany	Germany	NNP
cord-006229-7yoilsho	4753	9	)	)	-RRB-
cord-006229-7yoilsho	4753	10	and	and	CC
cord-006229-7yoilsho	4753	11	the	the	DT
cord-006229-7yoilsho	4753	12	HZI	HZI	NNP
cord-006229-7yoilsho	4753	13	Saarbrücken	Saarbrücken	NNP
cord-006229-7yoilsho	4753	14	(	(	-LRB-
cord-006229-7yoilsho	4753	15	Germany	Germany	NNP
cord-006229-7yoilsho	4753	16	)	)	-RRB-
cord-006229-7yoilsho	4753	17	,	,	,
cord-006229-7yoilsho	4753	18	we	-PRON-	PRP
cord-006229-7yoilsho	4753	19	were	be	VBD
cord-006229-7yoilsho	4753	20	able	able	JJ
cord-006229-7yoilsho	4753	21	to	to	TO
cord-006229-7yoilsho	4753	22	screen	screen	VB
cord-006229-7yoilsho	4753	23	over	over	IN
cord-006229-7yoilsho	4753	24	7000	7000	CD
cord-006229-7yoilsho	4753	25	purified	purify	VBN
cord-006229-7yoilsho	4753	26	compounds	compound	NNS
cord-006229-7yoilsho	4753	27	and	and	CC
cord-006229-7yoilsho	4753	28	over	over	IN
cord-006229-7yoilsho	4753	29	500	500	CD
cord-006229-7yoilsho	4753	30	extracts	extract	NNS
cord-006229-7yoilsho	4753	31	of	of	IN
cord-006229-7yoilsho	4753	32	myxobacteria	myxobacteria	NNS
cord-006229-7yoilsho	4753	33	.	.	.
cord-006229-7yoilsho	4754	1	During	during	IN
cord-006229-7yoilsho	4754	2	the	the	DT
cord-006229-7yoilsho	4754	3	ongoing	ongoing	JJ
cord-006229-7yoilsho	4754	4	screening	screening	NN
cord-006229-7yoilsho	4754	5	period	period	NN
cord-006229-7yoilsho	4754	6	,	,	,
cord-006229-7yoilsho	4754	7	the	the	DT
cord-006229-7yoilsho	4754	8	assay	assay	NN
cord-006229-7yoilsho	4754	9	generated	generate	VBD
cord-006229-7yoilsho	4754	10	four	four	CD
cord-006229-7yoilsho	4754	11	validated	validate	VBN
cord-006229-7yoilsho	4754	12	primary	primary	JJ
cord-006229-7yoilsho	4754	13	actives	active	NNS
cord-006229-7yoilsho	4754	14	,	,	,
cord-006229-7yoilsho	4754	15	which	which	WDT
cord-006229-7yoilsho	4754	16	corresponds	correspond	VBZ
cord-006229-7yoilsho	4754	17	to	to	IN
cord-006229-7yoilsho	4754	18	a	a	DT
cord-006229-7yoilsho	4754	19	positive	positive	JJ
cord-006229-7yoilsho	4754	20	hit	hit	NN
cord-006229-7yoilsho	4754	21	rate	rate	NN
cord-006229-7yoilsho	4754	22	of	of	IN
cord-006229-7yoilsho	4754	23	0,05	0,05	CD
cord-006229-7yoilsho	4754	24	%	%	NN
cord-006229-7yoilsho	4754	25	.	.	.
cord-006229-7yoilsho	4755	1	Additionally	additionally	RB
cord-006229-7yoilsho	4755	2	,	,	,
cord-006229-7yoilsho	4755	3	we	-PRON-	PRP
cord-006229-7yoilsho	4755	4	developed	develop	VBD
cord-006229-7yoilsho	4755	5	an	an	DT
cord-006229-7yoilsho	4755	6	elaborate	elaborate	JJ
cord-006229-7yoilsho	4755	7	follow	follow	NN
cord-006229-7yoilsho	4755	8	-	-	HYPH
cord-006229-7yoilsho	4755	9	up	up	NN
cord-006229-7yoilsho	4755	10	strategy	strategy	NN
cord-006229-7yoilsho	4755	11	to	to	TO
cord-006229-7yoilsho	4755	12	validate	validate	VB
cord-006229-7yoilsho	4755	13	positive	positive	JJ
cord-006229-7yoilsho	4755	14	hits	hit	NNS
cord-006229-7yoilsho	4755	15	,	,	,
cord-006229-7yoilsho	4755	16	which	which	WDT
cord-006229-7yoilsho	4755	17	includes	include	VBZ
cord-006229-7yoilsho	4755	18	a	a	DT
cord-006229-7yoilsho	4755	19	well	well	RB
cord-006229-7yoilsho	4755	20	-	-	HYPH
cord-006229-7yoilsho	4755	21	established	establish	VBN
cord-006229-7yoilsho	4755	22	mouse	mouse	NN
cord-006229-7yoilsho	4755	23	infection	infection	NN
cord-006229-7yoilsho	4755	24	model	model	NN
cord-006229-7yoilsho	4755	25	.	.	.
cord-006229-7yoilsho	4756	1	We	-PRON-	PRP
cord-006229-7yoilsho	4756	2	are	be	VBP
cord-006229-7yoilsho	4756	3	looking	look	VBG
cord-006229-7yoilsho	4756	4	forward	forward	RB
cord-006229-7yoilsho	4756	5	to	to	TO
cord-006229-7yoilsho	4756	6	escalate	escalate	VB
cord-006229-7yoilsho	4756	7	our	-PRON-	PRP$
cord-006229-7yoilsho	4756	8	screening	screening	NN
cord-006229-7yoilsho	4756	9	efforts	effort	NNS
cord-006229-7yoilsho	4756	10	and	and	CC
cord-006229-7yoilsho	4756	11	would	would	MD
cord-006229-7yoilsho	4756	12	like	like	VB
cord-006229-7yoilsho	4756	13	to	to	TO
cord-006229-7yoilsho	4756	14	use	use	VB
cord-006229-7yoilsho	4756	15	this	this	DT
cord-006229-7yoilsho	4756	16	abstract	abstract	JJ
cord-006229-7yoilsho	4756	17	to	to	TO
cord-006229-7yoilsho	4756	18	invite	invite	VB
cord-006229-7yoilsho	4756	19	all	all	DT
cord-006229-7yoilsho	4756	20	scientist	scientist	NN
cord-006229-7yoilsho	4756	21	who	who	WP
cord-006229-7yoilsho	4756	22	are	be	VBP
cord-006229-7yoilsho	4756	23	interested	interested	JJ
cord-006229-7yoilsho	4756	24	in	in	IN
cord-006229-7yoilsho	4756	25	testing	test	VBG
cord-006229-7yoilsho	4756	26	compound	compound	NN
cord-006229-7yoilsho	4756	27	/	/	SYM
cord-006229-7yoilsho	4756	28	natural	natural	JJ
cord-006229-7yoilsho	4756	29	extract	extract	NN
cord-006229-7yoilsho	4756	30	libraries	library	NNS
cord-006229-7yoilsho	4756	31	for	for	IN
cord-006229-7yoilsho	4756	32	an	an	DT
cord-006229-7yoilsho	4756	33	activity	activity	NN
cord-006229-7yoilsho	4756	34	against	against	IN
cord-006229-7yoilsho	4756	35	the	the	DT
cord-006229-7yoilsho	4756	36	target	target	NN
cord-006229-7yoilsho	4756	37	structure	structure	NN
cord-006229-7yoilsho	4756	38	SurA.	SurA.	NNP
cord-006229-7yoilsho	4757	1	The	the	DT
cord-006229-7yoilsho	4757	2	potential	potential	JJ
cord-006229-7yoilsho	4757	3	atypical	atypical	JJ
cord-006229-7yoilsho	4757	4	antipsychotic	antipsychotic	NN
cord-006229-7yoilsho	4757	5	and	and	CC
cord-006229-7yoilsho	4757	6	dopamine	dopamine	NN
cord-006229-7yoilsho	4757	7	D	D	NNP
cord-006229-7yoilsho	4757	8	2	2	CD
cord-006229-7yoilsho	4757	9	receptor	receptor	NN
cord-006229-7yoilsho	4757	10	partial	partial	JJ
cord-006229-7yoilsho	4757	11	agonist	agonist	NN
cord-006229-7yoilsho	4757	12	2bromoterguride	2bromoterguride	CD
cord-006229-7yoilsho	4757	13	antagonizes	antagonize	VBZ
cord-006229-7yoilsho	4757	14	phencyclidine	phencyclidine	NN
cord-006229-7yoilsho	4757	15	-	-	HYPH
cord-006229-7yoilsho	4757	16	and	and	CC
cord-006229-7yoilsho	4757	17	apomorphine	apomorphine	NN
cord-006229-7yoilsho	4757	18	-	-	HYPH
cord-006229-7yoilsho	4757	19	induced	induce	VBN
cord-006229-7yoilsho	4757	20	prepulse	prepulse	JJ
cord-006229-7yoilsho	4757	21	inhibition	inhibition	NN
cord-006229-7yoilsho	4757	22	and	and	CC
cord-006229-7yoilsho	4757	23	novel	novel	NN
cord-006229-7yoilsho	4757	24	object	object	NN
cord-006229-7yoilsho	4757	25	recognition	recognition	NN
cord-006229-7yoilsho	4757	26	deficits	deficit	NNS
cord-006229-7yoilsho	4757	27	in	in	IN
cord-006229-7yoilsho	4757	28	rats	rat	NNS
cord-006229-7yoilsho	4757	29	E.	E.	NNP
cord-006229-7yoilsho	4757	30	Tarland	Tarland	NNP
cord-006229-7yoilsho	4757	31	Objectives	Objectives	NNPS
cord-006229-7yoilsho	4757	32	:	:	:
cord-006229-7yoilsho	4757	33	Schizophrenia	Schizophrenia	NNP
cord-006229-7yoilsho	4757	34	is	be	VBZ
cord-006229-7yoilsho	4757	35	a	a	DT
cord-006229-7yoilsho	4757	36	disabling	disable	VBG
cord-006229-7yoilsho	4757	37	mental	mental	JJ
cord-006229-7yoilsho	4757	38	disorder	disorder	NN
cord-006229-7yoilsho	4757	39	affecting	affect	VBG
cord-006229-7yoilsho	4757	40	more	more	JJR
cord-006229-7yoilsho	4757	41	than	than	IN
cord-006229-7yoilsho	4757	42	21	21	CD
cord-006229-7yoilsho	4757	43	million	million	CD
cord-006229-7yoilsho	4757	44	people	people	NNS
cord-006229-7yoilsho	4757	45	worldwide	worldwide	RB
cord-006229-7yoilsho	4757	46	.	.	.
cord-006229-7yoilsho	4758	1	Available	available	JJ
cord-006229-7yoilsho	4758	2	medical	medical	JJ
cord-006229-7yoilsho	4758	3	therapies	therapy	NNS
cord-006229-7yoilsho	4758	4	are	be	VBP
cord-006229-7yoilsho	4758	5	effective	effective	JJ
cord-006229-7yoilsho	4758	6	in	in	IN
cord-006229-7yoilsho	4758	7	the	the	DT
cord-006229-7yoilsho	4758	8	treatment	treatment	NN
cord-006229-7yoilsho	4758	9	of	of	IN
cord-006229-7yoilsho	4758	10	psychosis	psychosis	NN
cord-006229-7yoilsho	4758	11	and	and	CC
cord-006229-7yoilsho	4758	12	other	other	JJ
cord-006229-7yoilsho	4758	13	positive	positive	JJ
cord-006229-7yoilsho	4758	14	symptoms	symptom	NNS
cord-006229-7yoilsho	4758	15	,	,	,
cord-006229-7yoilsho	4758	16	however	however	RB
cord-006229-7yoilsho	4758	17	come	come	VBP
cord-006229-7yoilsho	4758	18	with	with	IN
cord-006229-7yoilsho	4758	19	considerable	considerable	JJ
cord-006229-7yoilsho	4758	20	side	side	NN
cord-006229-7yoilsho	4758	21	effects	effect	NNS
cord-006229-7yoilsho	4758	22	and	and	CC
cord-006229-7yoilsho	4758	23	often	often	RB
cord-006229-7yoilsho	4758	24	fail	fail	VBP
cord-006229-7yoilsho	4758	25	to	to	TO
cord-006229-7yoilsho	4758	26	ameliorate	ameliorate	VB
cord-006229-7yoilsho	4758	27	cognitive	cognitive	JJ
cord-006229-7yoilsho	4758	28	deficits	deficit	NNS
cord-006229-7yoilsho	4758	29	and	and	CC
cord-006229-7yoilsho	4758	30	negative	negative	JJ
cord-006229-7yoilsho	4758	31	symptoms	symptom	NNS
cord-006229-7yoilsho	4758	32	of	of	IN
cord-006229-7yoilsho	4758	33	the	the	DT
cord-006229-7yoilsho	4758	34	disorder	disorder	NN
cord-006229-7yoilsho	4758	35	.	.	.
cord-006229-7yoilsho	4759	1	The	the	DT
cord-006229-7yoilsho	4759	2	dopamine	dopamine	NN
cord-006229-7yoilsho	4759	3	D	d	NN
cord-006229-7yoilsho	4759	4	2	2	CD
cord-006229-7yoilsho	4759	5	receptor	receptor	NN
cord-006229-7yoilsho	4759	6	partial	partial	JJ
cord-006229-7yoilsho	4759	7	agonist	agonist	NN
cord-006229-7yoilsho	4759	8	2-bromoterguride	2-bromoterguride	CD
cord-006229-7yoilsho	4759	9	(	(	-LRB-
cord-006229-7yoilsho	4759	10	2-BT	2-bt	CD
cord-006229-7yoilsho	4759	11	)	)	-RRB-
cord-006229-7yoilsho	4759	12	has	have	VBZ
cord-006229-7yoilsho	4759	13	recently	recently	RB
cord-006229-7yoilsho	4759	14	been	be	VBN
cord-006229-7yoilsho	4759	15	shown	show	VBN
cord-006229-7yoilsho	4759	16	to	to	TO
cord-006229-7yoilsho	4759	17	exhibit	exhibit	VB
cord-006229-7yoilsho	4759	18	antipsychotic	antipsychotic	JJ
cord-006229-7yoilsho	4759	19	effects	effect	NNS
cord-006229-7yoilsho	4759	20	in	in	IN
cord-006229-7yoilsho	4759	21	rats	rat	NNS
cord-006229-7yoilsho	4759	22	without	without	IN
cord-006229-7yoilsho	4759	23	causing	cause	VBG
cord-006229-7yoilsho	4759	24	adverse	adverse	JJ
cord-006229-7yoilsho	4759	25	side	side	NN
cord-006229-7yoilsho	4759	26	effects	effect	NNS
cord-006229-7yoilsho	4759	27	common	common	JJ
cord-006229-7yoilsho	4759	28	to	to	IN
cord-006229-7yoilsho	4759	29	antipsychotic	antipsychotic	JJ
cord-006229-7yoilsho	4759	30	drugs	drug	NNS
cord-006229-7yoilsho	4759	31	[	[	-LRB-
cord-006229-7yoilsho	4759	32	1	1	CD
cord-006229-7yoilsho	4759	33	]	]	-RRB-
cord-006229-7yoilsho	4759	34	.	.	.
cord-006229-7yoilsho	4760	1	To	to	TO
cord-006229-7yoilsho	4760	2	determine	determine	VB
cord-006229-7yoilsho	4760	3	its	-PRON-	PRP$
cord-006229-7yoilsho	4760	4	atypical	atypical	JJ
cord-006229-7yoilsho	4760	5	character	character	NN
cord-006229-7yoilsho	4760	6	in	in	IN
cord-006229-7yoilsho	4760	7	vivo	vivo	NNP
cord-006229-7yoilsho	4760	8	,	,	,
cord-006229-7yoilsho	4760	9	the	the	DT
cord-006229-7yoilsho	4760	10	ability	ability	NN
cord-006229-7yoilsho	4760	11	of	of	IN
cord-006229-7yoilsho	4760	12	2-BT	2-bt	CD
cord-006229-7yoilsho	4760	13	to	to	TO
cord-006229-7yoilsho	4760	14	antagonize	antagonize	VB
cord-006229-7yoilsho	4760	15	the	the	DT
cord-006229-7yoilsho	4760	16	disruptive	disruptive	JJ
cord-006229-7yoilsho	4760	17	effects	effect	NNS
cord-006229-7yoilsho	4760	18	of	of	IN
cord-006229-7yoilsho	4760	19	phencyclidine	phencyclidine	NN
cord-006229-7yoilsho	4760	20	(	(	-LRB-
cord-006229-7yoilsho	4760	21	PCP	PCP	NNP
cord-006229-7yoilsho	4760	22	)	)	-RRB-
cord-006229-7yoilsho	4760	23	and	and	CC
cord-006229-7yoilsho	4760	24	apomorphine	apomorphine	NN
cord-006229-7yoilsho	4760	25	on	on	IN
cord-006229-7yoilsho	4760	26	sensory	sensory	JJ
cord-006229-7yoilsho	4760	27	motor	motor	NN
cord-006229-7yoilsho	4760	28	gating	gating	NN
cord-006229-7yoilsho	4760	29	was	be	VBD
cord-006229-7yoilsho	4760	30	determined	determine	VBN
cord-006229-7yoilsho	4760	31	in	in	IN
cord-006229-7yoilsho	4760	32	the	the	DT
cord-006229-7yoilsho	4760	33	prepulse	prepulse	JJ
cord-006229-7yoilsho	4760	34	inhibition	inhibition	NN
cord-006229-7yoilsho	4760	35	paradigm	paradigm	NN
cord-006229-7yoilsho	4760	36	.	.	.
cord-006229-7yoilsho	4761	1	The	the	DT
cord-006229-7yoilsho	4761	2	effect	effect	NN
cord-006229-7yoilsho	4761	3	of	of	IN
cord-006229-7yoilsho	4761	4	2-BT	2-bt	CD
cord-006229-7yoilsho	4761	5	on	on	IN
cord-006229-7yoilsho	4761	6	cognitive	cognitive	JJ
cord-006229-7yoilsho	4761	7	deficits	deficit	NNS
cord-006229-7yoilsho	4761	8	was	be	VBD
cord-006229-7yoilsho	4761	9	assessed	assess	VBN
cord-006229-7yoilsho	4761	10	in	in	IN
cord-006229-7yoilsho	4761	11	the	the	DT
cord-006229-7yoilsho	4761	12	Novel	Novel	NNP
cord-006229-7yoilsho	4761	13	Object	Object	NNP
cord-006229-7yoilsho	4761	14	Recognition	Recognition	NNP
cord-006229-7yoilsho	4761	15	(	(	-LRB-
cord-006229-7yoilsho	4761	16	NOR	nor	CC
cord-006229-7yoilsho	4761	17	)	)	-RRB-
cord-006229-7yoilsho	4761	18	test	test	NN
cord-006229-7yoilsho	4761	19	after	after	IN
cord-006229-7yoilsho	4761	20	object	object	NN
cord-006229-7yoilsho	4761	21	recognition	recognition	NN
cord-006229-7yoilsho	4761	22	memory	memory	NN
cord-006229-7yoilsho	4761	23	deficits	deficit	NNS
cord-006229-7yoilsho	4761	24	were	be	VBD
cord-006229-7yoilsho	4761	25	induced	induce	VBN
cord-006229-7yoilsho	4761	26	by	by	IN
cord-006229-7yoilsho	4761	27	PCP	PCP	NNP
cord-006229-7yoilsho	4761	28	treatment	treatment	NN
cord-006229-7yoilsho	4761	29	.	.	.
cord-006229-7yoilsho	4762	1	Method	method	NN
cord-006229-7yoilsho	4762	2	:	:	:
cord-006229-7yoilsho	4762	3	10	10	CD
cord-006229-7yoilsho	4762	4	week	week	NN
cord-006229-7yoilsho	4762	5	old	old	JJ
cord-006229-7yoilsho	4762	6	male	male	JJ
cord-006229-7yoilsho	4762	7	Sprague	Sprague	NNP
cord-006229-7yoilsho	4762	8	-	-	HYPH
cord-006229-7yoilsho	4762	9	Dawley	Dawley	NNP
cord-006229-7yoilsho	4762	10	rats	rat	NNS
cord-006229-7yoilsho	4762	11	were	be	VBD
cord-006229-7yoilsho	4762	12	injected	inject	VBN
cord-006229-7yoilsho	4762	13	with	with	IN
cord-006229-7yoilsho	4762	14	2-BT	2-bt	CD
cord-006229-7yoilsho	4762	15	(	(	-LRB-
cord-006229-7yoilsho	4762	16	0.1	0.1	CD
cord-006229-7yoilsho	4762	17	or	or	CC
cord-006229-7yoilsho	4762	18	0.3mg	0.3mg	CD
cord-006229-7yoilsho	4762	19	/	/	SYM
cord-006229-7yoilsho	4762	20	kg	kg	NNS
cord-006229-7yoilsho	4762	21	;	;	:
cord-006229-7yoilsho	4762	22	i.p	i.p	NNP
cord-006229-7yoilsho	4762	23	.	.	NNP
cord-006229-7yoilsho	4762	24	)	)	-RRB-
cord-006229-7yoilsho	4762	25	followed	follow	VBN
cord-006229-7yoilsho	4762	26	by	by	IN
cord-006229-7yoilsho	4762	27	PCP	PCP	NNP
cord-006229-7yoilsho	4762	28	(	(	-LRB-
cord-006229-7yoilsho	4762	29	1.5mg	1.5mg	CD
cord-006229-7yoilsho	4762	30	/	/	SYM
cord-006229-7yoilsho	4762	31	kg	kg	NNS
cord-006229-7yoilsho	4762	32	;	;	:
cord-006229-7yoilsho	4762	33	s.c	s.c	NNP
cord-006229-7yoilsho	4762	34	.	.	NNP
cord-006229-7yoilsho	4762	35	)	)	-RRB-
cord-006229-7yoilsho	4762	36	or	or	CC
cord-006229-7yoilsho	4762	37	apomorphine	apomorphine	NNP
cord-006229-7yoilsho	4762	38	(	(	-LRB-
cord-006229-7yoilsho	4762	39	0.5mg	0.5mg	NNP
cord-006229-7yoilsho	4762	40	/	/	SYM
cord-006229-7yoilsho	4762	41	kg	kg	NNP
cord-006229-7yoilsho	4762	42	;	;	:
cord-006229-7yoilsho	4762	43	s.c	s.c	NNP
cord-006229-7yoilsho	4762	44	.	.	NNP
cord-006229-7yoilsho	4762	45	)	)	-RRB-
cord-006229-7yoilsho	4762	46	.	.	.
cord-006229-7yoilsho	4763	1	Prepulse	Prepulse	NNP
cord-006229-7yoilsho	4763	2	inhibition	inhibition	NN
cord-006229-7yoilsho	4763	3	was	be	VBD
cord-006229-7yoilsho	4763	4	measured	measure	VBN
cord-006229-7yoilsho	4763	5	in	in	IN
cord-006229-7yoilsho	4763	6	two	two	CD
cord-006229-7yoilsho	4763	7	sound	sound	NN
cord-006229-7yoilsho	4763	8	-	-	HYPH
cord-006229-7yoilsho	4763	9	proof	proof	NN
cord-006229-7yoilsho	4763	10	startle	startle	VB
cord-006229-7yoilsho	4763	11	chambers	chamber	NNS
cord-006229-7yoilsho	4763	12	.	.	.
cord-006229-7yoilsho	4764	1	The	the	DT
cord-006229-7yoilsho	4764	2	attenuating	attenuate	VBG
cord-006229-7yoilsho	4764	3	effect	effect	NN
cord-006229-7yoilsho	4764	4	of	of	IN
cord-006229-7yoilsho	4764	5	2-BT	2-bt	CD
cord-006229-7yoilsho	4764	6	(	(	-LRB-
cord-006229-7yoilsho	4764	7	0.1	0.1	CD
cord-006229-7yoilsho	4764	8	or	or	CC
cord-006229-7yoilsho	4764	9	0.3mg	0.3mg	CD
cord-006229-7yoilsho	4764	10	/	/	SYM
cord-006229-7yoilsho	4764	11	kg	kg	NNS
cord-006229-7yoilsho	4764	12	;	;	:
cord-006229-7yoilsho	4764	13	i.p	i.p	NNP
cord-006229-7yoilsho	4764	14	.	.	NNP
cord-006229-7yoilsho	4764	15	)	)	-RRB-
cord-006229-7yoilsho	4764	16	on	on	IN
cord-006229-7yoilsho	4764	17	visual	visual	JJ
cord-006229-7yoilsho	4764	18	learning	learning	NN
cord-006229-7yoilsho	4764	19	and	and	CC
cord-006229-7yoilsho	4764	20	memory	memory	NN
cord-006229-7yoilsho	4764	21	deficits	deficit	NNS
cord-006229-7yoilsho	4764	22	following	follow	VBG
cord-006229-7yoilsho	4764	23	subchronic	subchronic	NNP
cord-006229-7yoilsho	4764	24	administration	administration	NN
cord-006229-7yoilsho	4764	25	of	of	IN
cord-006229-7yoilsho	4764	26	PCP	PCP	NNP
cord-006229-7yoilsho	4764	27	(	(	-LRB-
cord-006229-7yoilsho	4764	28	5.0mg	5.0mg	CD
cord-006229-7yoilsho	4764	29	/	/	SYM
cord-006229-7yoilsho	4764	30	kg	kg	NNP
cord-006229-7yoilsho	4764	31	;	;	:
cord-006229-7yoilsho	4764	32	i.p	i.p	NNP
cord-006229-7yoilsho	4764	33	.	.	.
cord-006229-7yoilsho	4765	1	twice	twice	RB
cord-006229-7yoilsho	4765	2	daily	daily	RB
cord-006229-7yoilsho	4765	3	for	for	IN
cord-006229-7yoilsho	4765	4	7	7	CD
cord-006229-7yoilsho	4765	5	days	day	NNS
cord-006229-7yoilsho	4765	6	)	)	-RRB-
cord-006229-7yoilsho	4765	7	was	be	VBD
cord-006229-7yoilsho	4765	8	assessed	assess	VBN
cord-006229-7yoilsho	4765	9	in	in	IN
cord-006229-7yoilsho	4765	10	the	the	DT
cord-006229-7yoilsho	4766	1	NOR	nor	CC
cord-006229-7yoilsho	4766	2	task	task	NN
cord-006229-7yoilsho	4766	3	consisting	consist	VBG
cord-006229-7yoilsho	4766	4	of	of	IN
cord-006229-7yoilsho	4766	5	a	a	DT
cord-006229-7yoilsho	4766	6	3min	3min	CD
cord-006229-7yoilsho	4766	7	acquisition	acquisition	NN
cord-006229-7yoilsho	4766	8	trial	trial	NN
cord-006229-7yoilsho	4766	9	and	and	CC
cord-006229-7yoilsho	4766	10	a	a	DT
cord-006229-7yoilsho	4766	11	3min	3min	CD
cord-006229-7yoilsho	4766	12	retention	retention	NN
cord-006229-7yoilsho	4766	13	trial	trial	NN
cord-006229-7yoilsho	4766	14	separated	separate	VBN
cord-006229-7yoilsho	4766	15	by	by	IN
cord-006229-7yoilsho	4766	16	a	a	DT
cord-006229-7yoilsho	4766	17	1h	1h	CD
cord-006229-7yoilsho	4766	18	inter	inter	JJ
cord-006229-7yoilsho	4766	19	-	-	JJ
cord-006229-7yoilsho	4766	20	trial	trial	JJ
cord-006229-7yoilsho	4766	21	interval	interval	NN
cord-006229-7yoilsho	4766	22	.	.	.
cord-006229-7yoilsho	4767	1	Clozapine	Clozapine	NNP
cord-006229-7yoilsho	4767	2	(	(	-LRB-
cord-006229-7yoilsho	4767	3	5.0mg	5.0mg	CD
cord-006229-7yoilsho	4767	4	/	/	SYM
cord-006229-7yoilsho	4767	5	kg	kg	NNP
cord-006229-7yoilsho	4767	6	;	;	:
cord-006229-7yoilsho	4767	7	i.p	i.p	NNP
cord-006229-7yoilsho	4767	8	)	)	-RRB-
cord-006229-7yoilsho	4767	9	or	or	CC
cord-006229-7yoilsho	4767	10	haloperidol	haloperidol	NNP
cord-006229-7yoilsho	4767	11	(	(	-LRB-
cord-006229-7yoilsho	4767	12	0.1mg	0.1mg	CD
cord-006229-7yoilsho	4767	13	/	/	SYM
cord-006229-7yoilsho	4767	14	kg	kg	NN
cord-006229-7yoilsho	4767	15	;	;	:
cord-006229-7yoilsho	4767	16	i.p	i.p	NNP
cord-006229-7yoilsho	4767	17	)	)	-RRB-
cord-006229-7yoilsho	4767	18	were	be	VBD
cord-006229-7yoilsho	4767	19	used	use	VBN
cord-006229-7yoilsho	4767	20	as	as	IN
cord-006229-7yoilsho	4767	21	positive	positive	JJ
cord-006229-7yoilsho	4767	22	controls	control	NNS
cord-006229-7yoilsho	4767	23	.	.	.
cord-006229-7yoilsho	4768	1	Results	result	NNS
cord-006229-7yoilsho	4768	2	:	:	:
cord-006229-7yoilsho	4769	1	The	the	DT
cord-006229-7yoilsho	4769	2	dopamine	dopamine	NN
cord-006229-7yoilsho	4769	3	D	d	NN
cord-006229-7yoilsho	4769	4	2	2	CD
cord-006229-7yoilsho	4769	5	receptor	receptor	NN
cord-006229-7yoilsho	4769	6	partial	partial	JJ
cord-006229-7yoilsho	4769	7	agonist	agonist	NN
cord-006229-7yoilsho	4769	8	2-BT	2-bt	CD
cord-006229-7yoilsho	4769	9	(	(	-LRB-
cord-006229-7yoilsho	4769	10	0.3mg	0.3mg	CD
cord-006229-7yoilsho	4769	11	/	/	SYM
cord-006229-7yoilsho	4769	12	kg	kg	NNP
cord-006229-7yoilsho	4769	13	)	)	-RRB-
cord-006229-7yoilsho	4769	14	and	and	CC
cord-006229-7yoilsho	4769	15	the	the	DT
cord-006229-7yoilsho	4769	16	typical	typical	JJ
cord-006229-7yoilsho	4769	17	antipsychotic	antipsychotic	JJ
cord-006229-7yoilsho	4769	18	haloperidol	haloperidol	NNP
cord-006229-7yoilsho	4769	19	successfully	successfully	RB
cord-006229-7yoilsho	4769	20	antagonized	antagonize	VBD
cord-006229-7yoilsho	4769	21	apomorphine	apomorphine	NN
cord-006229-7yoilsho	4769	22	-	-	HYPH
cord-006229-7yoilsho	4769	23	induced	induce	VBN
cord-006229-7yoilsho	4769	24	PPI	PPI	NNP
cord-006229-7yoilsho	4769	25	-	-	HYPH
cord-006229-7yoilsho	4769	26	deficits	deficit	NNS
cord-006229-7yoilsho	4769	27	.	.	.
cord-006229-7yoilsho	4770	1	Interestingly	interestingly	RB
cord-006229-7yoilsho	4770	2	2-BT	2-bt	CD
cord-006229-7yoilsho	4770	3	also	also	RB
cord-006229-7yoilsho	4770	4	ameliorated	ameliorate	VBD
cord-006229-7yoilsho	4770	5	the	the	DT
cord-006229-7yoilsho	4770	6	PCP	PCP	NNP
cord-006229-7yoilsho	4770	7	-	-	HYPH
cord-006229-7yoilsho	4770	8	induced	induce	VBN
cord-006229-7yoilsho	4770	9	PPI	PPI	NNP
cord-006229-7yoilsho	4770	10	-	-	HYPH
cord-006229-7yoilsho	4770	11	deficits	deficit	NNS
cord-006229-7yoilsho	4770	12	to	to	IN
cord-006229-7yoilsho	4770	13	the	the	DT
cord-006229-7yoilsho	4770	14	same	same	JJ
cord-006229-7yoilsho	4770	15	extent	extent	NN
cord-006229-7yoilsho	4770	16	as	as	IN
cord-006229-7yoilsho	4770	17	the	the	DT
cord-006229-7yoilsho	4770	18	atypical	atypical	JJ
cord-006229-7yoilsho	4770	19	antipsychotic	antipsychotic	JJ
cord-006229-7yoilsho	4770	20	clozapine	clozapine	NN
cord-006229-7yoilsho	4770	21	.	.	.
cord-006229-7yoilsho	4771	1	Preliminary	preliminary	JJ
cord-006229-7yoilsho	4771	2	data	datum	NNS
cord-006229-7yoilsho	4771	3	from	from	IN
cord-006229-7yoilsho	4771	4	the	the	DT
cord-006229-7yoilsho	4771	5	NOR	NOR	NNP
cord-006229-7yoilsho	4771	6	test	test	NN
cord-006229-7yoilsho	4771	7	indicate	indicate	VBP
cord-006229-7yoilsho	4771	8	that	that	IN
cord-006229-7yoilsho	4771	9	2-BTreduces	2-btreduces	CD
cord-006229-7yoilsho	4771	10	subchronic	subchronic	JJ
cord-006229-7yoilsho	4771	11	PCP	PCP	NNP
cord-006229-7yoilsho	4771	12	-	-	HYPH
cord-006229-7yoilsho	4771	13	induced	induce	VBN
cord-006229-7yoilsho	4771	14	cognitive	cognitive	JJ
cord-006229-7yoilsho	4771	15	deficits	deficit	NNS
cord-006229-7yoilsho	4771	16	in	in	IN
cord-006229-7yoilsho	4771	17	novel	novel	JJ
cord-006229-7yoilsho	4771	18	object	object	NN
cord-006229-7yoilsho	4771	19	recognition	recognition	NN
cord-006229-7yoilsho	4771	20	analogous	analogous	JJ
cord-006229-7yoilsho	4771	21	to	to	IN
cord-006229-7yoilsho	4771	22	clozapine	clozapine	NNP
cord-006229-7yoilsho	4771	23	.	.	.
cord-006229-7yoilsho	4772	1	The	the	DT
cord-006229-7yoilsho	4772	2	disrupting	disrupt	VBG
cord-006229-7yoilsho	4772	3	effects	effect	NNS
cord-006229-7yoilsho	4772	4	of	of	IN
cord-006229-7yoilsho	4772	5	PCP	PCP	NNP
cord-006229-7yoilsho	4772	6	on	on	IN
cord-006229-7yoilsho	4772	7	PPI	PPI	NNP
cord-006229-7yoilsho	4772	8	are	be	VBP
cord-006229-7yoilsho	4772	9	mediated	mediate	VBN
cord-006229-7yoilsho	4772	10	by	by	IN
cord-006229-7yoilsho	4772	11	non	non	JJ
cord-006229-7yoilsho	4772	12	-	-	JJ
cord-006229-7yoilsho	4772	13	competitive	competitive	JJ
cord-006229-7yoilsho	4772	14	antagonism	antagonism	NN
cord-006229-7yoilsho	4772	15	at	at	IN
cord-006229-7yoilsho	4772	16	NMDA	NMDA	NNP
cord-006229-7yoilsho	4772	17	sites	site	NNS
cord-006229-7yoilsho	4772	18	indirectly	indirectly	RB
cord-006229-7yoilsho	4772	19	influencing	influence	VBG
cord-006229-7yoilsho	4772	20	a	a	DT
cord-006229-7yoilsho	4772	21	series	series	NN
cord-006229-7yoilsho	4772	22	of	of	IN
cord-006229-7yoilsho	4772	23	neurotransmitter	neurotransmitter	NN
cord-006229-7yoilsho	4772	24	systems	system	NNS
cord-006229-7yoilsho	4772	25	.	.	.
cord-006229-7yoilsho	4773	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	4773	2	results	result	NNS
cord-006229-7yoilsho	4773	3	indicate	indicate	VBP
cord-006229-7yoilsho	4773	4	that	that	IN
cord-006229-7yoilsho	4773	5	2-BT	2-bt	CD
cord-006229-7yoilsho	4773	6	mediates	mediate	VBZ
cord-006229-7yoilsho	4773	7	actions	action	NNS
cord-006229-7yoilsho	4773	8	at	at	IN
cord-006229-7yoilsho	4773	9	multiple	multiple	JJ
cord-006229-7yoilsho	4773	10	neurotransmitter	neurotransmitter	NN
cord-006229-7yoilsho	4773	11	receptors	receptor	NNS
cord-006229-7yoilsho	4773	12	as	as	IN
cord-006229-7yoilsho	4773	13	it	-PRON-	PRP
cord-006229-7yoilsho	4773	14	successfully	successfully	RB
cord-006229-7yoilsho	4773	15	ameliorated	ameliorate	VBD
cord-006229-7yoilsho	4773	16	both	both	CC
cord-006229-7yoilsho	4773	17	the	the	DT
cord-006229-7yoilsho	4773	18	PCP	PCP	NNP
cord-006229-7yoilsho	4773	19	-	-	:
cord-006229-7yoilsho	4773	20	and	and	CC
cord-006229-7yoilsho	4773	21	apomorphine	apomorphine	NN
cord-006229-7yoilsho	4773	22	-	-	HYPH
cord-006229-7yoilsho	4773	23	induced	induce	VBN
cord-006229-7yoilsho	4773	24	PPI	PPI	NNP
cord-006229-7yoilsho	4773	25	disruptions	disruption	NNS
cord-006229-7yoilsho	4773	26	in	in	IN
cord-006229-7yoilsho	4773	27	rats	rat	NNS
cord-006229-7yoilsho	4773	28	,	,	,
cord-006229-7yoilsho	4773	29	showing	show	VBG
cord-006229-7yoilsho	4773	30	an	an	DT
cord-006229-7yoilsho	4773	31	atypical	atypical	JJ
cord-006229-7yoilsho	4773	32	antipsychotic	antipsychotic	JJ
cord-006229-7yoilsho	4773	33	character	character	NN
cord-006229-7yoilsho	4773	34	.	.	.
cord-006229-7yoilsho	4774	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	4774	2	,	,	,
cord-006229-7yoilsho	4774	3	our	-PRON-	PRP$
cord-006229-7yoilsho	4774	4	preliminary	preliminary	JJ
cord-006229-7yoilsho	4774	5	results	result	NNS
cord-006229-7yoilsho	4774	6	support	support	VBP
cord-006229-7yoilsho	4774	7	the	the	DT
cord-006229-7yoilsho	4774	8	potential	potential	JJ
cord-006229-7yoilsho	4774	9	atypical	atypical	JJ
cord-006229-7yoilsho	4774	10	antipsychotic	antipsychotic	JJ
cord-006229-7yoilsho	4774	11	effect	effect	NN
cord-006229-7yoilsho	4774	12	of	of	IN
cord-006229-7yoilsho	4774	13	2-BT	2-bt	CD
cord-006229-7yoilsho	4774	14	as	as	IN
cord-006229-7yoilsho	4774	15	it	-PRON-	PRP
cord-006229-7yoilsho	4774	16	restored	restore	VBD
cord-006229-7yoilsho	4774	17	performance	performance	NN
cord-006229-7yoilsho	4774	18	in	in	IN
cord-006229-7yoilsho	4774	19	the	the	DT
cord-006229-7yoilsho	4774	20	NOR	NOR	NNP
cord-006229-7yoilsho	4774	21	test	test	NN
cord-006229-7yoilsho	4774	22	,	,	,
cord-006229-7yoilsho	4774	23	a	a	DT
cord-006229-7yoilsho	4774	24	test	test	NN
cord-006229-7yoilsho	4774	25	with	with	IN
cord-006229-7yoilsho	4774	26	good	good	JJ
cord-006229-7yoilsho	4774	27	predictive	predictive	JJ
cord-006229-7yoilsho	4774	28	validity	validity	NN
cord-006229-7yoilsho	4774	29	.	.	.
cord-006229-7yoilsho	4775	1	Due	due	IN
cord-006229-7yoilsho	4775	2	to	to	IN
cord-006229-7yoilsho	4775	3	the	the	DT
cord-006229-7yoilsho	4775	4	previously	previously	RB
cord-006229-7yoilsho	4775	5	shown	show	VBN
cord-006229-7yoilsho	4775	6	properties	property	NNS
cord-006229-7yoilsho	4775	7	and	and	CC
cord-006229-7yoilsho	4775	8	antipsychotic	antipsychotic	JJ
cord-006229-7yoilsho	4775	9	-	-	HYPH
cord-006229-7yoilsho	4775	10	like	like	JJ
cord-006229-7yoilsho	4775	11	effects	effect	NNS
cord-006229-7yoilsho	4775	12	of	of	IN
cord-006229-7yoilsho	4775	13	2-bromoterguride	2-bromoterguride	CD
cord-006229-7yoilsho	4775	14	[	[	-LRB-
cord-006229-7yoilsho	4775	15	1	1	CD
cord-006229-7yoilsho	4775	16	]	]	-RRB-
cord-006229-7yoilsho	4775	17	,	,	,
cord-006229-7yoilsho	4775	18	this	this	DT
cord-006229-7yoilsho	4775	19	substance	substance	NN
cord-006229-7yoilsho	4775	20	may	may	MD
cord-006229-7yoilsho	4775	21	be	be	VB
cord-006229-7yoilsho	4775	22	a	a	DT
cord-006229-7yoilsho	4775	23	promising	promising	JJ
cord-006229-7yoilsho	4775	24	candidate	candidate	NN
cord-006229-7yoilsho	4775	25	for	for	IN
cord-006229-7yoilsho	4775	26	treatment	treatment	NN
cord-006229-7yoilsho	4775	27	of	of	IN
cord-006229-7yoilsho	4775	28	schizophrenic	schizophrenic	JJ
cord-006229-7yoilsho	4775	29	patients	patient	NNS
cord-006229-7yoilsho	4775	30	.	.	.
cord-006229-7yoilsho	4776	1	Ongoing	ongoing	JJ
cord-006229-7yoilsho	4776	2	experiments	experiment	NNS
cord-006229-7yoilsho	4776	3	investigate	investigate	VBP
cord-006229-7yoilsho	4776	4	the	the	DT
cord-006229-7yoilsho	4776	5	potency	potency	NN
cord-006229-7yoilsho	4776	6	of	of	IN
cord-006229-7yoilsho	4776	7	2-BT	2-bt	CD
cord-006229-7yoilsho	4776	8	to	to	TO
cord-006229-7yoilsho	4776	9	improve	improve	VB
cord-006229-7yoilsho	4776	10	social	social	JJ
cord-006229-7yoilsho	4776	11	deficits	deficit	NNS
cord-006229-7yoilsho	4776	12	following	follow	VBG
cord-006229-7yoilsho	4776	13	a	a	DT
cord-006229-7yoilsho	4776	14	sub	sub	JJ
cord-006229-7yoilsho	4776	15	-	-	JJ
cord-006229-7yoilsho	4776	16	chronic	chronic	JJ
cord-006229-7yoilsho	4776	17	PCP	PCP	NNP
cord-006229-7yoilsho	4776	18	regime	regime	NN
cord-006229-7yoilsho	4776	19	in	in	IN
cord-006229-7yoilsho	4776	20	rats	rat	NNS
cord-006229-7yoilsho	4776	21	.	.	.
cord-006229-7yoilsho	4777	1	Background	background	NN
cord-006229-7yoilsho	4777	2	and	and	CC
cord-006229-7yoilsho	4777	3	Objectives	Objectives	NNPS
cord-006229-7yoilsho	4777	4	:	:	:
cord-006229-7yoilsho	4777	5	Cannabinoid-1	Cannabinoid-1	NNS
cord-006229-7yoilsho	4778	1	receptor	receptor	NN
cord-006229-7yoilsho	4778	2	signaling	signal	VBG
cord-006229-7yoilsho	4778	3	increases	increase	VBZ
cord-006229-7yoilsho	4778	4	the	the	DT
cord-006229-7yoilsho	4778	5	rewarding	rewarding	JJ
cord-006229-7yoilsho	4778	6	effects	effect	NNS
cord-006229-7yoilsho	4778	7	of	of	IN
cord-006229-7yoilsho	4778	8	food	food	NN
cord-006229-7yoilsho	4778	9	intake	intake	NN
cord-006229-7yoilsho	4778	10	and	and	CC
cord-006229-7yoilsho	4778	11	promotes	promote	VBZ
cord-006229-7yoilsho	4778	12	the	the	DT
cord-006229-7yoilsho	4778	13	growth	growth	NN
cord-006229-7yoilsho	4778	14	of	of	IN
cord-006229-7yoilsho	4778	15	adipocytes	adipocyte	NNS
cord-006229-7yoilsho	4778	16	,	,	,
cord-006229-7yoilsho	4778	17	whereas	whereas	IN
cord-006229-7yoilsho	4778	18	CB2	CB2	NNP
cord-006229-7yoilsho	4778	19	possibly	possibly	RB
cord-006229-7yoilsho	4778	20	opposes	oppose	VBZ
cord-006229-7yoilsho	4778	21	these	these	DT
cord-006229-7yoilsho	4778	22	pro	pro	JJ
cord-006229-7yoilsho	4778	23	-	-	JJ
cord-006229-7yoilsho	4778	24	obesity	obesity	JJ
cord-006229-7yoilsho	4778	25	effects	effect	NNS
cord-006229-7yoilsho	4778	26	by	by	IN
cord-006229-7yoilsho	4778	27	silencing	silence	VBG
cord-006229-7yoilsho	4778	28	the	the	DT
cord-006229-7yoilsho	4778	29	activated	activate	VBN
cord-006229-7yoilsho	4778	30	immune	immune	JJ
cord-006229-7yoilsho	4778	31	cells	cell	NNS
cord-006229-7yoilsho	4778	32	that	that	WDT
cord-006229-7yoilsho	4778	33	are	be	VBP
cord-006229-7yoilsho	4778	34	key	key	JJ
cord-006229-7yoilsho	4778	35	drivers	driver	NNS
cord-006229-7yoilsho	4778	36	of	of	IN
cord-006229-7yoilsho	4778	37	the	the	DT
cord-006229-7yoilsho	4778	38	metabolic	metabolic	JJ
cord-006229-7yoilsho	4778	39	syndrome	syndrome	NN
cord-006229-7yoilsho	4778	40	.	.	.
cord-006229-7yoilsho	4779	1	Pro	pro	JJ
cord-006229-7yoilsho	4779	2	-	-	:
cord-006229-7yoilsho	4779	3	and	and	CC
cord-006229-7yoilsho	4779	4	anti	anti	JJ
cord-006229-7yoilsho	4779	5	-	-	JJ
cord-006229-7yoilsho	4779	6	orexigenic	orexigenic	JJ
cord-006229-7yoilsho	4779	7	cannabimimetic	cannabimimetic	NN
cord-006229-7yoilsho	4779	8	signaling	signaling	NN
cord-006229-7yoilsho	4779	9	may	may	MD
cord-006229-7yoilsho	4779	10	become	become	VB
cord-006229-7yoilsho	4779	11	unbalanced	unbalanced	JJ
cord-006229-7yoilsho	4779	12	with	with	IN
cord-006229-7yoilsho	4779	13	age	age	NN
cord-006229-7yoilsho	4779	14	because	because	IN
cord-006229-7yoilsho	4779	15	of	of	IN
cord-006229-7yoilsho	4779	16	alterations	alteration	NNS
cord-006229-7yoilsho	4779	17	of	of	IN
cord-006229-7yoilsho	4779	18	the	the	DT
cord-006229-7yoilsho	4779	19	immune	immune	JJ
cord-006229-7yoilsho	4779	20	and	and	CC
cord-006229-7yoilsho	4779	21	endocannabinoid	endocannabinoid	NN
cord-006229-7yoilsho	4779	22	system	system	NN
cord-006229-7yoilsho	4779	23	.	.	.
cord-006229-7yoilsho	4780	1	Methods	method	NNS
cord-006229-7yoilsho	4780	2	:	:	:
cord-006229-7yoilsho	4780	3	To	to	TO
cord-006229-7yoilsho	4780	4	specifically	specifically	RB
cord-006229-7yoilsho	4780	5	address	address	VB
cord-006229-7yoilsho	4780	6	the	the	DT
cord-006229-7yoilsho	4780	7	role	role	NN
cord-006229-7yoilsho	4780	8	of	of	IN
cord-006229-7yoilsho	4780	9	CB2	CB2	NNP
cord-006229-7yoilsho	4780	10	for	for	IN
cord-006229-7yoilsho	4780	11	age	age	NN
cord-006229-7yoilsho	4780	12	-	-	HYPH
cord-006229-7yoilsho	4780	13	associated	associate	VBN
cord-006229-7yoilsho	4780	14	obesity	obesity	NN
cord-006229-7yoilsho	4780	15	we	-PRON-	PRP
cord-006229-7yoilsho	4780	16	analyzed	analyze	VBD
cord-006229-7yoilsho	4780	17	metabolic	metabolic	JJ
cord-006229-7yoilsho	4780	18	,	,	,
cord-006229-7yoilsho	4780	19	cardiovascular	cardiovascular	JJ
cord-006229-7yoilsho	4780	20	,	,	,
cord-006229-7yoilsho	4780	21	immune	immune	JJ
cord-006229-7yoilsho	4780	22	and	and	CC
cord-006229-7yoilsho	4780	23	neuronal	neuronal	JJ
cord-006229-7yoilsho	4780	24	functions	function	NNS
cord-006229-7yoilsho	4780	25	in	in	IN
cord-006229-7yoilsho	4780	26	1	1	CD
cord-006229-7yoilsho	4780	27	.	.	.
cord-006229-7yoilsho	4781	1	2	2	LS
cord-006229-7yoilsho	4781	2	-	-	SYM
cord-006229-7yoilsho	4781	3	1.8	1.8	CD
cord-006229-7yoilsho	4781	4	year	year	NN
cord-006229-7yoilsho	4781	5	old	old	JJ
cord-006229-7yoilsho	4781	6	CB2	CB2	NNP
cord-006229-7yoilsho	4781	7	-/and	-/and	VBD
cord-006229-7yoilsho	4781	8	control	control	NNP
cord-006229-7yoilsho	4781	9	mice	mouse	NNS
cord-006229-7yoilsho	4781	10	,	,	,
cord-006229-7yoilsho	4781	11	fed	feed	VBN
cord-006229-7yoilsho	4781	12	with	with	IN
cord-006229-7yoilsho	4781	13	a	a	DT
cord-006229-7yoilsho	4781	14	standard	standard	JJ
cord-006229-7yoilsho	4781	15	diet	diet	NN
cord-006229-7yoilsho	4781	16	and	and	CC
cord-006229-7yoilsho	4781	17	assessed	assess	VBN
cord-006229-7yoilsho	4781	18	effects	effect	NNS
cord-006229-7yoilsho	4781	19	of	of	IN
cord-006229-7yoilsho	4781	20	the	the	DT
cord-006229-7yoilsho	4781	21	CB2	CB2	NNP
cord-006229-7yoilsho	4781	22	agonist	agonist	NN
cord-006229-7yoilsho	4781	23	,	,	,
cord-006229-7yoilsho	4781	24	HU308	HU308	NNP
cord-006229-7yoilsho	4781	25	during	during	IN
cord-006229-7yoilsho	4781	26	high	high	JJ
cord-006229-7yoilsho	4781	27	fat	fat	NN
cord-006229-7yoilsho	4781	28	diet	diet	NN
cord-006229-7yoilsho	4781	29	in	in	IN
cord-006229-7yoilsho	4781	30	12	12	CD
cord-006229-7yoilsho	4781	31	-	-	SYM
cord-006229-7yoilsho	4781	32	16	16	CD
cord-006229-7yoilsho	4781	33	week	week	NN
cord-006229-7yoilsho	4781	34	old	old	JJ
cord-006229-7yoilsho	4781	35	mice	mouse	NNS
cord-006229-7yoilsho	4781	36	.	.	.
cord-006229-7yoilsho	4782	1	Results	result	NNS
cord-006229-7yoilsho	4782	2	:	:	:
cord-006229-7yoilsho	4783	1	The	the	DT
cord-006229-7yoilsho	4783	2	CB2	CB2	NNP
cord-006229-7yoilsho	4783	3	-/mice	-/mice	NNP
cord-006229-7yoilsho	4783	4	were	be	VBD
cord-006229-7yoilsho	4783	5	obese	obese	JJ
cord-006229-7yoilsho	4783	6	with	with	IN
cord-006229-7yoilsho	4783	7	hypertrophy	hypertrophy	NN
cord-006229-7yoilsho	4783	8	of	of	IN
cord-006229-7yoilsho	4783	9	visceral	visceral	JJ
cord-006229-7yoilsho	4783	10	fat	fat	NN
cord-006229-7yoilsho	4783	11	,	,	,
cord-006229-7yoilsho	4783	12	immune	immune	JJ
cord-006229-7yoilsho	4783	13	cell	cell	NN
cord-006229-7yoilsho	4783	14	polarization	polarization	NN
cord-006229-7yoilsho	4783	15	towards	towards	IN
cord-006229-7yoilsho	4783	16	pro	pro	JJ
cord-006229-7yoilsho	4783	17	-	-	JJ
cord-006229-7yoilsho	4783	18	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	4783	19	sub	sub	NN
cord-006229-7yoilsho	4783	20	-	-	NNS
cord-006229-7yoilsho	4783	21	populations	population	NNS
cord-006229-7yoilsho	4783	22	in	in	IN
cord-006229-7yoilsho	4783	23	fat	fat	NN
cord-006229-7yoilsho	4783	24	and	and	CC
cord-006229-7yoilsho	4783	25	liver	liver	NN
cord-006229-7yoilsho	4783	26	and	and	CC
cord-006229-7yoilsho	4783	27	hypertension	hypertension	NN
cord-006229-7yoilsho	4783	28	,	,	,
cord-006229-7yoilsho	4783	29	as	as	RB
cord-006229-7yoilsho	4783	30	well	well	RB
cord-006229-7yoilsho	4783	31	as	as	IN
cord-006229-7yoilsho	4783	32	increased	increase	VBN
cord-006229-7yoilsho	4783	33	mortality	mortality	NN
cord-006229-7yoilsho	4783	34	despite	despite	IN
cord-006229-7yoilsho	4783	35	normal	normal	JJ
cord-006229-7yoilsho	4783	36	blood	blood	NN
cord-006229-7yoilsho	4783	37	glucose	glucose	NN
cord-006229-7yoilsho	4783	38	.	.	.
cord-006229-7yoilsho	4784	1	They	-PRON-	PRP
cord-006229-7yoilsho	4784	2	also	also	RB
cord-006229-7yoilsho	4784	3	developed	develop	VBD
cord-006229-7yoilsho	4784	4	stronger	strong	JJR
cord-006229-7yoilsho	4784	5	paw	paw	NN
cord-006229-7yoilsho	4784	6	inflammation	inflammation	NN
cord-006229-7yoilsho	4784	7	and	and	CC
cord-006229-7yoilsho	4784	8	a	a	DT
cord-006229-7yoilsho	4784	9	premature	premature	JJ
cord-006229-7yoilsho	4784	10	loss	loss	NN
cord-006229-7yoilsho	4784	11	of	of	IN
cord-006229-7yoilsho	4784	12	transient	transient	JJ
cord-006229-7yoilsho	4784	13	receptor	receptor	NN
cord-006229-7yoilsho	4784	14	potential	potential	JJ
cord-006229-7yoilsho	4784	15	responsiveness	responsiveness	NN
cord-006229-7yoilsho	4784	16	in	in	IN
cord-006229-7yoilsho	4784	17	primary	primary	JJ
cord-006229-7yoilsho	4784	18	sensory	sensory	JJ
cord-006229-7yoilsho	4784	19	neurons	neuron	NNS
cord-006229-7yoilsho	4784	20	,	,	,
cord-006229-7yoilsho	4784	21	a	a	DT
cord-006229-7yoilsho	4784	22	phenomenon	phenomenon	NN
cord-006229-7yoilsho	4784	23	typical	typical	JJ
cord-006229-7yoilsho	4784	24	for	for	IN
cord-006229-7yoilsho	4784	25	small	small	JJ
cord-006229-7yoilsho	4784	26	fiber	fiber	NN
cord-006229-7yoilsho	4784	27	disease	disease	NN
cord-006229-7yoilsho	4784	28	.	.	.
cord-006229-7yoilsho	4785	1	The	the	DT
cord-006229-7yoilsho	4785	2	CB2	CB2	NNP
cord-006229-7yoilsho	4785	3	agonist	agonist	NN
cord-006229-7yoilsho	4785	4	HU308	HU308	NNP
cord-006229-7yoilsho	4785	5	prevented	prevent	VBD
cord-006229-7yoilsho	4785	6	HFD	HFD	NNP
cord-006229-7yoilsho	4785	7	-	-	HYPH
cord-006229-7yoilsho	4785	8	evoked	evoke	VBN
cord-006229-7yoilsho	4785	9	hypertension	hypertension	NN
cord-006229-7yoilsho	4785	10	,	,	,
cord-006229-7yoilsho	4785	11	reduced	reduce	VBN
cord-006229-7yoilsho	4785	12	HFDevoked	hfdevoked	JJ
cord-006229-7yoilsho	4785	13	polarization	polarization	NN
cord-006229-7yoilsho	4785	14	of	of	IN
cord-006229-7yoilsho	4785	15	adipose	adipose	JJ
cord-006229-7yoilsho	4785	16	tissue	tissue	NN
cord-006229-7yoilsho	4785	17	macrophages	macrophage	NNS
cord-006229-7yoilsho	4785	18	towards	towards	IN
cord-006229-7yoilsho	4785	19	the	the	DT
cord-006229-7yoilsho	4785	20	M1-like	M1-like	``
cord-006229-7yoilsho	4785	21	proinflammatory	proinflammatory	JJ
cord-006229-7yoilsho	4785	22	type	type	NN
cord-006229-7yoilsho	4785	23	and	and	CC
cord-006229-7yoilsho	4785	24	reduced	reduce	VBD
cord-006229-7yoilsho	4785	25	HFD	HFD	NNP
cord-006229-7yoilsho	4785	26	-	-	HYPH
cord-006229-7yoilsho	4785	27	evoked	evoke	VBN
cord-006229-7yoilsho	4785	28	nociceptive	nociceptive	JJ
cord-006229-7yoilsho	4785	29	hypersensitivity	hypersensitivity	NN
cord-006229-7yoilsho	4785	30	but	but	CC
cord-006229-7yoilsho	4785	31	had	have	VBD
cord-006229-7yoilsho	4785	32	no	no	DT
cord-006229-7yoilsho	4785	33	effect	effect	NN
cord-006229-7yoilsho	4785	34	on	on	IN
cord-006229-7yoilsho	4785	35	weight	weight	NN
cord-006229-7yoilsho	4785	36	gain	gain	NN
cord-006229-7yoilsho	4785	37	.	.	.
cord-006229-7yoilsho	4786	1	Conclusion	conclusion	NN
cord-006229-7yoilsho	4786	2	:	:	:
cord-006229-7yoilsho	4786	3	CB2	CB2	NNP
cord-006229-7yoilsho	4786	4	agonists	agonist	NNS
cord-006229-7yoilsho	4786	5	may	may	MD
cord-006229-7yoilsho	4786	6	fortify	fortify	VB
cord-006229-7yoilsho	4786	7	CB2-mediated	cb2-mediate	VBN
cord-006229-7yoilsho	4786	8	anti	anti	JJ
cord-006229-7yoilsho	4786	9	-	-	JJ
cord-006229-7yoilsho	4786	10	obesity	obesity	JJ
cord-006229-7yoilsho	4786	11	signaling	signaling	NN
cord-006229-7yoilsho	4786	12	without	without	IN
cord-006229-7yoilsho	4786	13	the	the	DT
cord-006229-7yoilsho	4786	14	risk	risk	NN
cord-006229-7yoilsho	4786	15	of	of	IN
cord-006229-7yoilsho	4786	16	anti	anti	JJ
cord-006229-7yoilsho	4786	17	-	-	JJ
cord-006229-7yoilsho	4786	18	CB1	cb1	JJ
cord-006229-7yoilsho	4786	19	mediated	mediate	VBN
cord-006229-7yoilsho	4786	20	depression	depression	NN
cord-006229-7yoilsho	4786	21	that	that	WDT
cord-006229-7yoilsho	4786	22	caused	cause	VBD
cord-006229-7yoilsho	4786	23	the	the	DT
cord-006229-7yoilsho	4786	24	failure	failure	NN
cord-006229-7yoilsho	4786	25	of	of	IN
cord-006229-7yoilsho	4786	26	rimonabant	rimonabant	NN
cord-006229-7yoilsho	4786	27	.	.	.
cord-006229-7yoilsho	4787	1	Leishmaniasis	leishmaniasis	NN
cord-006229-7yoilsho	4787	2	is	be	VBZ
cord-006229-7yoilsho	4787	3	a	a	DT
cord-006229-7yoilsho	4787	4	neglected	neglect	VBN
cord-006229-7yoilsho	4787	5	tropical	tropical	JJ
cord-006229-7yoilsho	4787	6	disease	disease	NN
cord-006229-7yoilsho	4787	7	caused	cause	VBN
cord-006229-7yoilsho	4787	8	by	by	IN
cord-006229-7yoilsho	4787	9	Leishmania	Leishmania	NNP
cord-006229-7yoilsho	4787	10	,	,	,
cord-006229-7yoilsho	4787	11	eukaryotic	eukaryotic	JJ
cord-006229-7yoilsho	4787	12	protozoal	protozoal	NN
cord-006229-7yoilsho	4787	13	organisms	organism	NNS
cord-006229-7yoilsho	4787	14	,	,	,
cord-006229-7yoilsho	4787	15	which	which	WDT
cord-006229-7yoilsho	4787	16	infect	infect	VBP
cord-006229-7yoilsho	4787	17	humans	human	NNS
cord-006229-7yoilsho	4787	18	and	and	CC
cord-006229-7yoilsho	4787	19	other	other	JJ
cord-006229-7yoilsho	4787	20	mammals	mammal	NNS
cord-006229-7yoilsho	4787	21	.	.	.
cord-006229-7yoilsho	4788	1	This	this	DT
cord-006229-7yoilsho	4788	2	disease	disease	NN
cord-006229-7yoilsho	4788	3	is	be	VBZ
cord-006229-7yoilsho	4788	4	transmitted	transmit	VBN
cord-006229-7yoilsho	4788	5	by	by	IN
cord-006229-7yoilsho	4788	6	sandflies	sandfly	NNS
cord-006229-7yoilsho	4788	7	of	of	IN
cord-006229-7yoilsho	4788	8	the	the	DT
cord-006229-7yoilsho	4788	9	genus	genus	NN
cord-006229-7yoilsho	4788	10	Phlebotomus	Phlebotomus	NNP
cord-006229-7yoilsho	4788	11	.	.	.
cord-006229-7yoilsho	4789	1	Due	due	IN
cord-006229-7yoilsho	4789	2	to	to	IN
cord-006229-7yoilsho	4789	3	global	global	JJ
cord-006229-7yoilsho	4789	4	warming	warming	NN
cord-006229-7yoilsho	4789	5	the	the	DT
cord-006229-7yoilsho	4789	6	endemic	endemic	JJ
cord-006229-7yoilsho	4789	7	region	region	NN
cord-006229-7yoilsho	4789	8	of	of	IN
cord-006229-7yoilsho	4789	9	these	these	DT
cord-006229-7yoilsho	4789	10	vectors	vector	NNS
cord-006229-7yoilsho	4789	11	expands	expand	VBZ
cord-006229-7yoilsho	4789	12	further	further	RB
cord-006229-7yoilsho	4789	13	to	to	IN
cord-006229-7yoilsho	4789	14	northwards	northwards	RB
cord-006229-7yoilsho	4789	15	and	and	CC
cord-006229-7yoilsho	4789	16	threatens	threaten	VBZ
cord-006229-7yoilsho	4789	17	South	south	JJ
cord-006229-7yoilsho	4789	18	European	european	JJ
cord-006229-7yoilsho	4789	19	countries	country	NNS
cord-006229-7yoilsho	4789	20	as	as	RB
cord-006229-7yoilsho	4789	21	well	well	RB
cord-006229-7yoilsho	4789	22	.	.	.
cord-006229-7yoilsho	4790	1	The	the	DT
cord-006229-7yoilsho	4790	2	treatment	treatment	NN
cord-006229-7yoilsho	4790	3	of	of	IN
cord-006229-7yoilsho	4790	4	Leishmaniasis	leishmaniasis	NN
cord-006229-7yoilsho	4790	5	is	be	VBZ
cord-006229-7yoilsho	4790	6	difficult	difficult	JJ
cord-006229-7yoilsho	4790	7	due	due	IN
cord-006229-7yoilsho	4790	8	to	to	IN
cord-006229-7yoilsho	4790	9	toxicity	toxicity	NN
cord-006229-7yoilsho	4790	10	and	and	CC
cord-006229-7yoilsho	4790	11	resistance	resistance	NN
cord-006229-7yoilsho	4790	12	development	development	NN
cord-006229-7yoilsho	4790	13	for	for	IN
cord-006229-7yoilsho	4790	14	current	current	JJ
cord-006229-7yoilsho	4790	15	drugs	drug	NNS
cord-006229-7yoilsho	4790	16	.	.	.
cord-006229-7yoilsho	4791	1	The	the	DT
cord-006229-7yoilsho	4791	2	so	so	RB
cord-006229-7yoilsho	4791	3	far	far	RB
cord-006229-7yoilsho	4791	4	unexplored	unexplored	JJ
cord-006229-7yoilsho	4791	5	inhibition	inhibition	NN
cord-006229-7yoilsho	4791	6	of	of	IN
cord-006229-7yoilsho	4791	7	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	4791	8	functions	function	NNS
cord-006229-7yoilsho	4791	9	in	in	IN
cord-006229-7yoilsho	4791	10	Leishmania	Leishmania	NNP
cord-006229-7yoilsho	4791	11	by	by	IN
cord-006229-7yoilsho	4791	12	natural	natural	JJ
cord-006229-7yoilsho	4791	13	products	product	NNS
cord-006229-7yoilsho	4791	14	or	or	CC
cord-006229-7yoilsho	4791	15	even	even	RB
cord-006229-7yoilsho	4791	16	food	food	NN
cord-006229-7yoilsho	4791	17	ingredients	ingredient	NNS
cord-006229-7yoilsho	4791	18	seems	seem	VBZ
cord-006229-7yoilsho	4791	19	to	to	TO
cord-006229-7yoilsho	4791	20	be	be	VB
cord-006229-7yoilsho	4791	21	an	an	DT
cord-006229-7yoilsho	4791	22	interesting	interesting	JJ
cord-006229-7yoilsho	4791	23	alternative	alternative	NN
cord-006229-7yoilsho	4791	24	.	.	.
cord-006229-7yoilsho	4792	1	Two	two	CD
cord-006229-7yoilsho	4792	2	food	food	NN
cord-006229-7yoilsho	4792	3	ingredients	ingredient	NNS
cord-006229-7yoilsho	4792	4	,	,	,
cord-006229-7yoilsho	4792	5	resveratrol	resveratrol	JJ
cord-006229-7yoilsho	4792	6	(	(	-LRB-
cord-006229-7yoilsho	4792	7	Res	Res	NNP
cord-006229-7yoilsho	4792	8	)	)	-RRB-
cord-006229-7yoilsho	4792	9	and	and	CC
cord-006229-7yoilsho	4792	10	xanthohumol	xanthohumol	NNP
cord-006229-7yoilsho	4792	11	(	(	-LRB-
cord-006229-7yoilsho	4792	12	Xan	Xan	NNP
cord-006229-7yoilsho	4792	13	)	)	-RRB-
cord-006229-7yoilsho	4792	14	,	,	,
cord-006229-7yoilsho	4792	15	were	be	VBD
cord-006229-7yoilsho	4792	16	widely	widely	RB
cord-006229-7yoilsho	4792	17	studied	study	VBN
cord-006229-7yoilsho	4792	18	in	in	IN
cord-006229-7yoilsho	4792	19	mammalian	mammalian	JJ
cord-006229-7yoilsho	4792	20	cells	cell	NNS
cord-006229-7yoilsho	4792	21	but	but	CC
cord-006229-7yoilsho	4792	22	little	little	JJ
cord-006229-7yoilsho	4792	23	is	be	VBZ
cord-006229-7yoilsho	4792	24	known	know	VBN
cord-006229-7yoilsho	4792	25	about	about	IN
cord-006229-7yoilsho	4792	26	their	-PRON-	PRP$
cord-006229-7yoilsho	4792	27	actions	action	NNS
cord-006229-7yoilsho	4792	28	on	on	IN
cord-006229-7yoilsho	4792	29	protozoal	protozoal	NNP
cord-006229-7yoilsho	4792	30	parasites	parasite	NNS
cord-006229-7yoilsho	4792	31	.	.	.
cord-006229-7yoilsho	4793	1	Therefore	therefore	RB
cord-006229-7yoilsho	4793	2	,	,	,
cord-006229-7yoilsho	4793	3	we	-PRON-	PRP
cord-006229-7yoilsho	4793	4	compared	compare	VBD
cord-006229-7yoilsho	4793	5	the	the	DT
cord-006229-7yoilsho	4793	6	influence	influence	NN
cord-006229-7yoilsho	4793	7	of	of	IN
cord-006229-7yoilsho	4793	8	Res	Res	NNP
cord-006229-7yoilsho	4793	9	and	and	CC
cord-006229-7yoilsho	4793	10	Xan	Xan	NNP
cord-006229-7yoilsho	4793	11	on	on	IN
cord-006229-7yoilsho	4793	12	the	the	DT
cord-006229-7yoilsho	4793	13	function	function	NN
cord-006229-7yoilsho	4793	14	of	of	IN
cord-006229-7yoilsho	4793	15	leishmanial	leishmanial	JJ
cord-006229-7yoilsho	4793	16	and	and	CC
cord-006229-7yoilsho	4793	17	mammalian	mammalian	JJ
cord-006229-7yoilsho	4793	18	mitochondria	mitochondrion	NNS
cord-006229-7yoilsho	4793	19	.	.	.
cord-006229-7yoilsho	4794	1	Anti	anti	JJ
cord-006229-7yoilsho	4794	2	-	-	JJ
cord-006229-7yoilsho	4794	3	leishmanial	leishmanial	JJ
cord-006229-7yoilsho	4794	4	activities	activity	NNS
cord-006229-7yoilsho	4794	5	of	of	IN
cord-006229-7yoilsho	4794	6	xenobiotics	xenobiotic	NNS
cord-006229-7yoilsho	4794	7	were	be	VBD
cord-006229-7yoilsho	4794	8	assessed	assess	VBN
cord-006229-7yoilsho	4794	9	in	in	IN
cord-006229-7yoilsho	4794	10	cell	cell	NN
cord-006229-7yoilsho	4794	11	culture	culture	NN
cord-006229-7yoilsho	4794	12	of	of	IN
cord-006229-7yoilsho	4794	13	Leishmania	Leishmania	NNP
cord-006229-7yoilsho	4794	14	tarentolae	tarentolae	NNP
cord-006229-7yoilsho	4794	15	promastigotes	promastigote	NNS
cord-006229-7yoilsho	4794	16	(	(	-LRB-
cord-006229-7yoilsho	4794	17	LtP	LtP	NNP
cord-006229-7yoilsho	4794	18	)	)	-RRB-
cord-006229-7yoilsho	4794	19	,	,	,
cord-006229-7yoilsho	4794	20	Leishmania	Leishmania	NNP
cord-006229-7yoilsho	4794	21	amazonensis	amazonensis	NN
cord-006229-7yoilsho	4794	22	amastigotes	amastigotes	NNP
cord-006229-7yoilsho	4794	23	(	(	-LRB-
cord-006229-7yoilsho	4794	24	LaA	LaA	NNP
cord-006229-7yoilsho	4794	25	)	)	-RRB-
cord-006229-7yoilsho	4794	26	and	and	CC
cord-006229-7yoilsho	4794	27	compared	compare	VBN
cord-006229-7yoilsho	4794	28	to	to	IN
cord-006229-7yoilsho	4794	29	peritoneal	peritoneal	JJ
cord-006229-7yoilsho	4794	30	macrophages	macrophage	NNS
cord-006229-7yoilsho	4794	31	from	from	IN
cord-006229-7yoilsho	4794	32	mouse	mouse	NN
cord-006229-7yoilsho	4794	33	(	(	-LRB-
cord-006229-7yoilsho	4794	34	PMM	PMM	NNP
cord-006229-7yoilsho	4794	35	)	)	-RRB-
cord-006229-7yoilsho	4794	36	using	use	VBG
cord-006229-7yoilsho	4794	37	viability	viability	NN
cord-006229-7yoilsho	4794	38	assays	assay	NNS
cord-006229-7yoilsho	4794	39	.	.	.
cord-006229-7yoilsho	4795	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	4795	2	,	,	,
cord-006229-7yoilsho	4795	3	mechanistic	mechanistic	JJ
cord-006229-7yoilsho	4795	4	studies	study	NNS
cord-006229-7yoilsho	4795	5	regarding	regard	VBG
cord-006229-7yoilsho	4795	6	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	4795	7	functions	function	NNS
cord-006229-7yoilsho	4795	8	were	be	VBD
cord-006229-7yoilsho	4795	9	conducted	conduct	VBN
cord-006229-7yoilsho	4795	10	in	in	IN
cord-006229-7yoilsho	4795	11	LtP	ltp	NN
cord-006229-7yoilsho	4795	12	,	,	,
cord-006229-7yoilsho	4795	13	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	4795	14	fractions	fraction	NNS
cord-006229-7yoilsho	4795	15	isolated	isolate	VBN
cord-006229-7yoilsho	4795	16	from	from	IN
cord-006229-7yoilsho	4795	17	LtP	ltp	NN
cord-006229-7yoilsho	4795	18	and	and	CC
cord-006229-7yoilsho	4795	19	bovine	bovine	JJ
cord-006229-7yoilsho	4795	20	heart	heart	NN
cord-006229-7yoilsho	4795	21	submitochondrial	submitochondrial	JJ
cord-006229-7yoilsho	4795	22	particles	particle	NNS
cord-006229-7yoilsho	4795	23	using	use	VBG
cord-006229-7yoilsho	4795	24	oxygen	oxygen	NN
cord-006229-7yoilsho	4795	25	consumption	consumption	NN
cord-006229-7yoilsho	4795	26	measurements	measurement	NNS
cord-006229-7yoilsho	4795	27	,	,	,
cord-006229-7yoilsho	4795	28	assays	assay	NNS
cord-006229-7yoilsho	4795	29	of	of	IN
cord-006229-7yoilsho	4795	30	individual	individual	JJ
cord-006229-7yoilsho	4795	31	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	4795	32	complex	complex	JJ
cord-006229-7yoilsho	4795	33	activities	activity	NNS
cord-006229-7yoilsho	4795	34	,	,	,
cord-006229-7yoilsho	4795	35	membrane	membrane	NN
cord-006229-7yoilsho	4795	36	potential	potential	NN
cord-006229-7yoilsho	4795	37	and	and	CC
cord-006229-7yoilsho	4795	38	superoxide	superoxide	JJ
cord-006229-7yoilsho	4795	39	radical	radical	JJ
cord-006229-7yoilsho	4795	40	formation	formation	NN
cord-006229-7yoilsho	4795	41	by	by	IN
cord-006229-7yoilsho	4795	42	photometry	photometry	NN
cord-006229-7yoilsho	4795	43	,	,	,
cord-006229-7yoilsho	4795	44	fluorimetry	fluorimetry	NN
cord-006229-7yoilsho	4795	45	and	and	CC
cord-006229-7yoilsho	4795	46	electron	electron	NN
cord-006229-7yoilsho	4795	47	spin	spin	NN
cord-006229-7yoilsho	4795	48	resonance	resonance	NN
cord-006229-7yoilsho	4795	49	spectroscopy	spectroscopy	NN
cord-006229-7yoilsho	4795	50	.	.	.
cord-006229-7yoilsho	4796	1	In	in	IN
cord-006229-7yoilsho	4796	2	LtP	ltp	NN
cord-006229-7yoilsho	4796	3	,	,	,
cord-006229-7yoilsho	4796	4	Xan	Xan	NNP
cord-006229-7yoilsho	4796	5	inhibited	inhibit	VBD
cord-006229-7yoilsho	4796	6	the	the	DT
cord-006229-7yoilsho	4796	7	viability	viability	NN
cord-006229-7yoilsho	4796	8	more	more	RBR
cord-006229-7yoilsho	4796	9	effective	effective	JJ
cord-006229-7yoilsho	4796	10	than	than	IN
cord-006229-7yoilsho	4796	11	Res	Res	NNP
cord-006229-7yoilsho	4796	12	(	(	-LRB-
cord-006229-7yoilsho	4796	13	IC	IC	NNP
cord-006229-7yoilsho	4796	14	50	50	CD
cord-006229-7yoilsho	4796	15	:	:	:
cord-006229-7yoilsho	4797	1	Xan	Xan	NNP
cord-006229-7yoilsho	4798	1	23	23	CD
cord-006229-7yoilsho	4798	2	µM	µm	UH
cord-006229-7yoilsho	4798	3	,	,	,
cord-006229-7yoilsho	4798	4	Res	Res	NNP
cord-006229-7yoilsho	4798	5	161	161	CD
cord-006229-7yoilsho	4798	6	µM	µm	CD
cord-006229-7yoilsho	4798	7	)	)	-RRB-
cord-006229-7yoilsho	4798	8	.	.	.
cord-006229-7yoilsho	4799	1	Likewise	likewise	RB
cord-006229-7yoilsho	4799	2	,	,	,
cord-006229-7yoilsho	4799	3	Xan	Xan	NNP
cord-006229-7yoilsho	4799	4	and	and	CC
cord-006229-7yoilsho	4799	5	Res	Res	NNP
cord-006229-7yoilsho	4799	6	demonstrated	demonstrate	VBD
cord-006229-7yoilsho	4799	7	anti	anti	JJ
cord-006229-7yoilsho	4799	8	-	-	JJ
cord-006229-7yoilsho	4799	9	leishmanial	leishmanial	JJ
cord-006229-7yoilsho	4799	10	activity	activity	NN
cord-006229-7yoilsho	4799	11	in	in	IN
cord-006229-7yoilsho	4799	12	LaA	LaA	NNP
cord-006229-7yoilsho	4799	13	(	(	-LRB-
cord-006229-7yoilsho	4799	14	IC	IC	NNP
cord-006229-7yoilsho	4799	15	50	50	CD
cord-006229-7yoilsho	4799	16	:	:	:
cord-006229-7yoilsho	4799	17	Xan	Xan	NNP
cord-006229-7yoilsho	4799	18	7	7	CD
cord-006229-7yoilsho	4799	19	µM	µM	NNP
cord-006229-7yoilsho	4799	20	,	,	,
cord-006229-7yoilsho	4799	21	Res	Res	NNP
cord-006229-7yoilsho	4799	22	14	14	CD
cord-006229-7yoilsho	4799	23	µM	µm	CD
cord-006229-7yoilsho	4799	24	)	)	-RRB-
cord-006229-7yoilsho	4799	25	while	while	NN
cord-006229-7yoilsho	4799	26	had	have	VBD
cord-006229-7yoilsho	4799	27	less	less	JJR
cord-006229-7yoilsho	4799	28	influence	influence	NN
cord-006229-7yoilsho	4799	29	on	on	IN
cord-006229-7yoilsho	4799	30	the	the	DT
cord-006229-7yoilsho	4799	31	viability	viability	NN
cord-006229-7yoilsho	4799	32	of	of	IN
cord-006229-7yoilsho	4799	33	PMM	PMM	NNP
cord-006229-7yoilsho	4799	34	(	(	-LRB-
cord-006229-7yoilsho	4799	35	IC	IC	NNP
cord-006229-7yoilsho	4799	36	50	50	CD
cord-006229-7yoilsho	4799	37	:	:	:
cord-006229-7yoilsho	4799	38	Xan	Xan	NNP
cord-006229-7yoilsho	4799	39	68	68	CD
cord-006229-7yoilsho	4799	40	µM	µm	XX
cord-006229-7yoilsho	4799	41	,	,	,
cord-006229-7yoilsho	4800	1	Res	Res	NNP
cord-006229-7yoilsho	4800	2	>	>	XX
cord-006229-7yoilsho	4800	3	438	438	CD
cord-006229-7yoilsho	4800	4	µM	µm	CD
cord-006229-7yoilsho	4800	5	)	)	-RRB-
cord-006229-7yoilsho	4800	6	.	.	.
cord-006229-7yoilsho	4801	1	In	in	IN
cord-006229-7yoilsho	4801	2	contrast	contrast	NN
cord-006229-7yoilsho	4801	3	to	to	IN
cord-006229-7yoilsho	4801	4	Res	Res	NNP
cord-006229-7yoilsho	4801	5	,	,	,
cord-006229-7yoilsho	4801	6	Xan	Xan	NNP
cord-006229-7yoilsho	4801	7	strongly	strongly	RB
cord-006229-7yoilsho	4801	8	inhibited	inhibit	VBD
cord-006229-7yoilsho	4801	9	oxygen	oxygen	NN
cord-006229-7yoilsho	4801	10	consumption	consumption	NN
cord-006229-7yoilsho	4801	11	in	in	IN
cord-006229-7yoilsho	4801	12	Leishmania	Leishmania	NNP
cord-006229-7yoilsho	4801	13	.	.	.
cord-006229-7yoilsho	4802	1	Further	further	JJ
cord-006229-7yoilsho	4802	2	studies	study	NNS
cord-006229-7yoilsho	4802	3	demonstrated	demonstrate	VBD
cord-006229-7yoilsho	4802	4	that	that	IN
cord-006229-7yoilsho	4802	5	this	this	DT
cord-006229-7yoilsho	4802	6	is	be	VBZ
cord-006229-7yoilsho	4802	7	based	base	VBN
cord-006229-7yoilsho	4802	8	on	on	IN
cord-006229-7yoilsho	4802	9	the	the	DT
cord-006229-7yoilsho	4802	10	inhibition	inhibition	NN
cord-006229-7yoilsho	4802	11	of	of	IN
cord-006229-7yoilsho	4802	12	the	the	DT
cord-006229-7yoilsho	4802	13	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	4802	14	electron	electron	NN
cord-006229-7yoilsho	4802	15	transfer	transfer	NN
cord-006229-7yoilsho	4802	16	complex	complex	JJ
cord-006229-7yoilsho	4802	17	II	II	NNP
cord-006229-7yoilsho	4802	18	/	/	SYM
cord-006229-7yoilsho	4802	19	III	III	NNP
cord-006229-7yoilsho	4802	20	by	by	IN
cord-006229-7yoilsho	4802	21	Xan	Xan	NNP
cord-006229-7yoilsho	4802	22	which	which	WDT
cord-006229-7yoilsho	4802	23	was	be	VBD
cord-006229-7yoilsho	4802	24	less	less	RBR
cord-006229-7yoilsho	4802	25	pronounced	pronounce	VBN
cord-006229-7yoilsho	4802	26	with	with	IN
cord-006229-7yoilsho	4802	27	Res	Res	NNP
cord-006229-7yoilsho	4802	28	.	.	.
cord-006229-7yoilsho	4803	1	However	however	RB
cord-006229-7yoilsho	4803	2	,	,	,
cord-006229-7yoilsho	4803	3	Xan	Xan	NNP
cord-006229-7yoilsho	4803	4	also	also	RB
cord-006229-7yoilsho	4803	5	demonstrated	demonstrate	VBD
cord-006229-7yoilsho	4803	6	inhibitory	inhibitory	JJ
cord-006229-7yoilsho	4803	7	activity	activity	NN
cord-006229-7yoilsho	4803	8	on	on	IN
cord-006229-7yoilsho	4803	9	mammalian	mammalian	JJ
cord-006229-7yoilsho	4803	10	mitochondrial	mitochondrial	NN
cord-006229-7yoilsho	4803	11	complex	complex	JJ
cord-006229-7yoilsho	4803	12	III	iii	CD
cord-006229-7yoilsho	4803	13	.	.	.
cord-006229-7yoilsho	4804	1	In	in	IN
cord-006229-7yoilsho	4804	2	addition	addition	NN
cord-006229-7yoilsho	4804	3	,	,	,
cord-006229-7yoilsho	4804	4	Xan	Xan	NNP
cord-006229-7yoilsho	4804	5	caused	cause	VBD
cord-006229-7yoilsho	4804	6	no	no	DT
cord-006229-7yoilsho	4804	7	decrease	decrease	NN
cord-006229-7yoilsho	4804	8	of	of	IN
cord-006229-7yoilsho	4804	9	the	the	DT
cord-006229-7yoilsho	4804	10	membrane	membrane	NN
cord-006229-7yoilsho	4804	11	potential	potential	NN
cord-006229-7yoilsho	4804	12	in	in	IN
cord-006229-7yoilsho	4804	13	leishmanial	leishmanial	JJ
cord-006229-7yoilsho	4804	14	mitochondria	mitochondrion	NNS
cord-006229-7yoilsho	4804	15	,	,	,
cord-006229-7yoilsho	4804	16	while	while	IN
cord-006229-7yoilsho	4804	17	Res	Res	NNP
cord-006229-7yoilsho	4804	18	resulted	result	VBD
cord-006229-7yoilsho	4804	19	in	in	IN
cord-006229-7yoilsho	4804	20	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	4804	21	uncoupling	uncoupling	NN
cord-006229-7yoilsho	4804	22	.	.	.
cord-006229-7yoilsho	4805	1	Neither	neither	CC
cord-006229-7yoilsho	4805	2	Xan	Xan	NNP
cord-006229-7yoilsho	4805	3	nor	nor	CC
cord-006229-7yoilsho	4805	4	Res	Res	NNP
cord-006229-7yoilsho	4805	5	increased	increase	VBN
cord-006229-7yoilsho	4805	6	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	4805	7	superoxide	superoxide	NN
cord-006229-7yoilsho	4805	8	release	release	NN
cord-006229-7yoilsho	4805	9	in	in	IN
cord-006229-7yoilsho	4806	1	LtP.	LtP.	NNP
cord-006229-7yoilsho	4807	1	These	these	DT
cord-006229-7yoilsho	4807	2	data	datum	NNS
cord-006229-7yoilsho	4807	3	show	show	VBP
cord-006229-7yoilsho	4807	4	that	that	IN
cord-006229-7yoilsho	4807	5	Res	Res	NNP
cord-006229-7yoilsho	4807	6	,	,	,
cord-006229-7yoilsho	4807	7	a	a	DT
cord-006229-7yoilsho	4807	8	major	major	JJ
cord-006229-7yoilsho	4807	9	polyphenol	polyphenol	NN
cord-006229-7yoilsho	4807	10	from	from	IN
cord-006229-7yoilsho	4807	11	red	red	JJ
cord-006229-7yoilsho	4807	12	wine	wine	NN
cord-006229-7yoilsho	4807	13	,	,	,
cord-006229-7yoilsho	4807	14	and	and	CC
cord-006229-7yoilsho	4807	15	Xan	Xan	NNP
cord-006229-7yoilsho	4807	16	,	,	,
cord-006229-7yoilsho	4807	17	an	an	DT
cord-006229-7yoilsho	4807	18	ingredient	ingredient	NN
cord-006229-7yoilsho	4807	19	of	of	IN
cord-006229-7yoilsho	4807	20	hop	hop	NN
cord-006229-7yoilsho	4807	21	-	-	HYPH
cord-006229-7yoilsho	4807	22	containing	contain	VBG
cord-006229-7yoilsho	4807	23	beer	beer	NN
cord-006229-7yoilsho	4807	24	,	,	,
cord-006229-7yoilsho	4807	25	may	may	MD
cord-006229-7yoilsho	4807	26	have	have	VB
cord-006229-7yoilsho	4807	27	selective	selective	JJ
cord-006229-7yoilsho	4807	28	anti	anti	JJ
cord-006229-7yoilsho	4807	29	-	-	JJ
cord-006229-7yoilsho	4807	30	leishmanial	leishmanial	JJ
cord-006229-7yoilsho	4807	31	activity	activity	NN
cord-006229-7yoilsho	4807	32	.	.	.
cord-006229-7yoilsho	4808	1	Tryptophan	tryptophan	NN
cord-006229-7yoilsho	4808	2	hydroxylase	hydroxylase	NN
cord-006229-7yoilsho	4808	3	(	(	-LRB-
cord-006229-7yoilsho	4808	4	TPH	TPH	NNP
cord-006229-7yoilsho	4808	5	)	)	-RRB-
cord-006229-7yoilsho	4808	6	is	be	VBZ
cord-006229-7yoilsho	4808	7	the	the	DT
cord-006229-7yoilsho	4808	8	rate	rate	NN
cord-006229-7yoilsho	4808	9	-	-	HYPH
cord-006229-7yoilsho	4808	10	limiting	limit	VBG
cord-006229-7yoilsho	4808	11	enzyme	enzyme	NN
cord-006229-7yoilsho	4808	12	in	in	IN
cord-006229-7yoilsho	4808	13	serotonin	serotonin	NN
cord-006229-7yoilsho	4808	14	(	(	-LRB-
cord-006229-7yoilsho	4808	15	5-HT	5-ht	CD
cord-006229-7yoilsho	4808	16	)	)	-RRB-
cord-006229-7yoilsho	4808	17	biosynthesis	biosynthesis	NN
cord-006229-7yoilsho	4808	18	.	.	.
cord-006229-7yoilsho	4809	1	Its	-PRON-	PRP$
cord-006229-7yoilsho	4809	2	two	two	CD
cord-006229-7yoilsho	4809	3	existing	exist	VBG
cord-006229-7yoilsho	4809	4	isoforms	isoform	NNS
cord-006229-7yoilsho	4809	5	are	be	VBP
cord-006229-7yoilsho	4809	6	exclusively	exclusively	RB
cord-006229-7yoilsho	4809	7	expressed	express	VBN
cord-006229-7yoilsho	4809	8	in	in	IN
cord-006229-7yoilsho	4809	9	the	the	DT
cord-006229-7yoilsho	4809	10	periphery	periphery	NN
cord-006229-7yoilsho	4809	11	(	(	-LRB-
cord-006229-7yoilsho	4809	12	TPH1	TPH1	NNP
cord-006229-7yoilsho	4809	13	)	)	-RRB-
cord-006229-7yoilsho	4809	14	,	,	,
cord-006229-7yoilsho	4809	15	or	or	CC
cord-006229-7yoilsho	4809	16	the	the	DT
cord-006229-7yoilsho	4809	17	raphe	raphe	NN
cord-006229-7yoilsho	4809	18	nuclei	nucleus	NNS
cord-006229-7yoilsho	4809	19	of	of	IN
cord-006229-7yoilsho	4809	20	the	the	DT
cord-006229-7yoilsho	4809	21	brainstem	brainstem	NN
cord-006229-7yoilsho	4809	22	(	(	-LRB-
cord-006229-7yoilsho	4809	23	TPH2	TPH2	NNP
cord-006229-7yoilsho	4809	24	)	)	-RRB-
cord-006229-7yoilsho	4809	25	and	and	CC
cord-006229-7yoilsho	4809	26	the	the	DT
cord-006229-7yoilsho	4809	27	respective	respective	JJ
cord-006229-7yoilsho	4809	28	5-HT	5-ht	CD
cord-006229-7yoilsho	4809	29	populations	population	NNS
cord-006229-7yoilsho	4809	30	are	be	VBP
cord-006229-7yoilsho	4809	31	distinctly	distinctly	RB
cord-006229-7yoilsho	4809	32	separated	separate	VBN
cord-006229-7yoilsho	4809	33	by	by	IN
cord-006229-7yoilsho	4809	34	the	the	DT
cord-006229-7yoilsho	4809	35	blood	blood	NN
cord-006229-7yoilsho	4809	36	-	-	HYPH
cord-006229-7yoilsho	4809	37	brain	brain	NN
cord-006229-7yoilsho	4809	38	barrier	barrier	NN
cord-006229-7yoilsho	4809	39	,	,	,
cord-006229-7yoilsho	4809	40	offering	offer	VBG
cord-006229-7yoilsho	4809	41	the	the	DT
cord-006229-7yoilsho	4809	42	possibility	possibility	NN
cord-006229-7yoilsho	4809	43	to	to	TO
cord-006229-7yoilsho	4809	44	pharmacologically	pharmacologically	RB
cord-006229-7yoilsho	4809	45	modulate	modulate	VB
cord-006229-7yoilsho	4809	46	central	central	JJ
cord-006229-7yoilsho	4809	47	and	and	CC
cord-006229-7yoilsho	4809	48	peripheral	peripheral	JJ
cord-006229-7yoilsho	4809	49	functions	function	NNS
cord-006229-7yoilsho	4809	50	in	in	IN
cord-006229-7yoilsho	4809	51	an	an	DT
cord-006229-7yoilsho	4809	52	independent	independent	JJ
cord-006229-7yoilsho	4809	53	manner	manner	NN
cord-006229-7yoilsho	4809	54	.	.	.
cord-006229-7yoilsho	4810	1	Peripheral	peripheral	JJ
cord-006229-7yoilsho	4810	2	5-HT	5-ht	CD
cord-006229-7yoilsho	4810	3	is	be	VBZ
cord-006229-7yoilsho	4810	4	mainly	mainly	RB
cord-006229-7yoilsho	4810	5	produced	produce	VBN
cord-006229-7yoilsho	4810	6	by	by	IN
cord-006229-7yoilsho	4810	7	TPH1-expressing	tph1-expresse	VBG
cord-006229-7yoilsho	4810	8	enterochromaffin	enterochromaffin	NN
cord-006229-7yoilsho	4810	9	cells	cell	NNS
cord-006229-7yoilsho	4810	10	of	of	IN
cord-006229-7yoilsho	4810	11	the	the	DT
cord-006229-7yoilsho	4810	12	gut	gut	NN
cord-006229-7yoilsho	4810	13	and	and	CC
cord-006229-7yoilsho	4810	14	taken	take	VBN
cord-006229-7yoilsho	4810	15	up	up	RP
cord-006229-7yoilsho	4810	16	into	into	IN
cord-006229-7yoilsho	4810	17	platelets	platelet	NNS
cord-006229-7yoilsho	4810	18	and	and	CC
cord-006229-7yoilsho	4810	19	transported	transport	VBN
cord-006229-7yoilsho	4810	20	in	in	IN
cord-006229-7yoilsho	4810	21	the	the	DT
cord-006229-7yoilsho	4810	22	blood	blood	NN
cord-006229-7yoilsho	4810	23	stream	stream	NN
cord-006229-7yoilsho	4810	24	.	.	.
cord-006229-7yoilsho	4811	1	Upon	upon	IN
cord-006229-7yoilsho	4811	2	platelet	platelet	NN
cord-006229-7yoilsho	4811	3	activation	activation	NN
cord-006229-7yoilsho	4811	4	,	,	,
cord-006229-7yoilsho	4811	5	5-HT	5-ht	CD
cord-006229-7yoilsho	4811	6	is	be	VBZ
cord-006229-7yoilsho	4811	7	rapidly	rapidly	RB
cord-006229-7yoilsho	4811	8	released	release	VBN
cord-006229-7yoilsho	4811	9	and	and	CC
cord-006229-7yoilsho	4811	10	locally	locally	RB
cord-006229-7yoilsho	4811	11	induces	induce	VBZ
cord-006229-7yoilsho	4811	12	multiple	multiple	JJ
cord-006229-7yoilsho	4811	13	effects	effect	NNS
cord-006229-7yoilsho	4811	14	,	,	,
cord-006229-7yoilsho	4811	15	such	such	JJ
cord-006229-7yoilsho	4811	16	as	as	IN
cord-006229-7yoilsho	4811	17	vasoconstriction	vasoconstriction	NN
cord-006229-7yoilsho	4811	18	,	,	,
cord-006229-7yoilsho	4811	19	cell	cell	NN
cord-006229-7yoilsho	4811	20	proliferation	proliferation	NN
cord-006229-7yoilsho	4811	21	or	or	CC
cord-006229-7yoilsho	4811	22	fibrosis	fibrosis	NN
cord-006229-7yoilsho	4811	23	and	and	CC
cord-006229-7yoilsho	4811	24	is	be	VBZ
cord-006229-7yoilsho	4811	25	furthermore	furthermore	RB
cord-006229-7yoilsho	4811	26	involved	involve	VBN
cord-006229-7yoilsho	4811	27	in	in	IN
cord-006229-7yoilsho	4811	28	the	the	DT
cord-006229-7yoilsho	4811	29	regulation	regulation	NN
cord-006229-7yoilsho	4811	30	of	of	IN
cord-006229-7yoilsho	4811	31	e.g.	e.g.	JJ
cord-006229-7yoilsho	4811	32	vascular	vascular	JJ
cord-006229-7yoilsho	4811	33	tone	tone	NN
cord-006229-7yoilsho	4811	34	,	,	,
cord-006229-7yoilsho	4811	35	gut	gut	NN
cord-006229-7yoilsho	4811	36	motility	motility	NN
cord-006229-7yoilsho	4811	37	,	,	,
cord-006229-7yoilsho	4811	38	primary	primary	JJ
cord-006229-7yoilsho	4811	39	hemostasis	hemostasis	NN
cord-006229-7yoilsho	4811	40	,	,	,
cord-006229-7yoilsho	4811	41	insulin	insulin	NN
cord-006229-7yoilsho	4811	42	secretion	secretion	NN
cord-006229-7yoilsho	4811	43	and	and	CC
cord-006229-7yoilsho	4811	44	T	t	NN
cord-006229-7yoilsho	4811	45	-	-	HYPH
cord-006229-7yoilsho	4811	46	cell	cell	NN
cord-006229-7yoilsho	4811	47	-	-	HYPH
cord-006229-7yoilsho	4811	48	mediated	mediate	VBN
cord-006229-7yoilsho	4811	49	immune	immune	JJ
cord-006229-7yoilsho	4811	50	response	response	NN
cord-006229-7yoilsho	4811	51	.	.	.
cord-006229-7yoilsho	4812	1	Following	follow	VBG
cord-006229-7yoilsho	4812	2	the	the	DT
cord-006229-7yoilsho	4812	3	classical	classical	JJ
cord-006229-7yoilsho	4812	4	early	early	JJ
cord-006229-7yoilsho	4812	5	drug	drug	NN
cord-006229-7yoilsho	4812	6	development	development	NN
cord-006229-7yoilsho	4812	7	pathway	pathway	NN
cord-006229-7yoilsho	4812	8	,	,	,
cord-006229-7yoilsho	4812	9	we	-PRON-	PRP
cord-006229-7yoilsho	4812	10	developed	develop	VBD
cord-006229-7yoilsho	4812	11	a	a	DT
cord-006229-7yoilsho	4812	12	fluorescencebased	fluorescencebase	VBN
cord-006229-7yoilsho	4812	13	TPH	tph	NN
cord-006229-7yoilsho	4812	14	activity	activity	NN
cord-006229-7yoilsho	4812	15	assay	assay	NN
cord-006229-7yoilsho	4812	16	and	and	CC
cord-006229-7yoilsho	4812	17	performed	perform	VBD
cord-006229-7yoilsho	4812	18	a	a	DT
cord-006229-7yoilsho	4812	19	high	high	JJ
cord-006229-7yoilsho	4812	20	-	-	HYPH
cord-006229-7yoilsho	4812	21	throughput	throughput	NN
cord-006229-7yoilsho	4812	22	screening	screening	NN
cord-006229-7yoilsho	4812	23	of	of	IN
cord-006229-7yoilsho	4812	24	about	about	RB
cord-006229-7yoilsho	4812	25	37000	37000	CD
cord-006229-7yoilsho	4812	26	small	small	JJ
cord-006229-7yoilsho	4812	27	chemical	chemical	NN
cord-006229-7yoilsho	4812	28	compounds	compound	NNS
cord-006229-7yoilsho	4812	29	.	.	.
cord-006229-7yoilsho	4813	1	We	-PRON-	PRP
cord-006229-7yoilsho	4813	2	discovered	discover	VBD
cord-006229-7yoilsho	4813	3	a	a	DT
cord-006229-7yoilsho	4813	4	novel	novel	JJ
cord-006229-7yoilsho	4813	5	class	class	NN
cord-006229-7yoilsho	4813	6	of	of	IN
cord-006229-7yoilsho	4813	7	TPH	TPH	NNP
cord-006229-7yoilsho	4813	8	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	4813	9	,	,	,
cord-006229-7yoilsho	4813	10	which	which	WDT
cord-006229-7yoilsho	4813	11	was	be	VBD
cord-006229-7yoilsho	4813	12	thoroughly	thoroughly	RB
cord-006229-7yoilsho	4813	13	validated	validate	VBN
cord-006229-7yoilsho	4813	14	in	in	IN
cord-006229-7yoilsho	4813	15	a	a	DT
cord-006229-7yoilsho	4813	16	variety	variety	NN
cord-006229-7yoilsho	4813	17	of	of	IN
cord-006229-7yoilsho	4813	18	in	in	FW
cord-006229-7yoilsho	4813	19	vitro	vitro	FW
cord-006229-7yoilsho	4813	20	assay	assay	NN
cord-006229-7yoilsho	4813	21	setups	setup	NNS
cord-006229-7yoilsho	4813	22	.	.	.
cord-006229-7yoilsho	4814	1	Combining	combine	VBG
cord-006229-7yoilsho	4814	2	medicinal	medicinal	JJ
cord-006229-7yoilsho	4814	3	chemistry	chemistry	NN
cord-006229-7yoilsho	4814	4	and	and	CC
cord-006229-7yoilsho	4814	5	X	x	NN
cord-006229-7yoilsho	4814	6	-	-	NN
cord-006229-7yoilsho	4814	7	ray	ray	NN
cord-006229-7yoilsho	4814	8	crystallography	crystallography	NN
cord-006229-7yoilsho	4814	9	,	,	,
cord-006229-7yoilsho	4814	10	we	-PRON-	PRP
cord-006229-7yoilsho	4814	11	further	further	RB
cord-006229-7yoilsho	4814	12	aimed	aim	VBD
cord-006229-7yoilsho	4814	13	to	to	TO
cord-006229-7yoilsho	4814	14	develop	develop	VB
cord-006229-7yoilsho	4814	15	these	these	DT
cord-006229-7yoilsho	4814	16	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	4814	17	into	into	IN
cord-006229-7yoilsho	4814	18	preclinical	preclinical	JJ
cord-006229-7yoilsho	4814	19	drug	drug	NN
cord-006229-7yoilsho	4814	20	candidates	candidate	NNS
cord-006229-7yoilsho	4814	21	.	.	.
cord-006229-7yoilsho	4815	1	To	to	IN
cord-006229-7yoilsho	4815	2	date	date	NN
cord-006229-7yoilsho	4815	3	we	-PRON-	PRP
cord-006229-7yoilsho	4815	4	were	be	VBD
cord-006229-7yoilsho	4815	5	able	able	JJ
cord-006229-7yoilsho	4815	6	to	to	TO
cord-006229-7yoilsho	4815	7	generate	generate	VB
cord-006229-7yoilsho	4815	8	and	and	CC
cord-006229-7yoilsho	4815	9	patent	patent	VB
cord-006229-7yoilsho	4815	10	a	a	DT
cord-006229-7yoilsho	4815	11	series	series	NN
cord-006229-7yoilsho	4815	12	of	of	IN
cord-006229-7yoilsho	4815	13	novel	novel	NN
cord-006229-7yoilsho	4815	14	TPH	TPH	NNP
cord-006229-7yoilsho	4815	15	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	4815	16	with	with	IN
cord-006229-7yoilsho	4815	17	optimized	optimize	VBN
cord-006229-7yoilsho	4815	18	affinity	affinity	NN
cord-006229-7yoilsho	4815	19	and	and	CC
cord-006229-7yoilsho	4815	20	an	an	DT
cord-006229-7yoilsho	4815	21	in	in	FW
cord-006229-7yoilsho	4815	22	vitro	vitro	FW
cord-006229-7yoilsho	4815	23	IC	IC	NNP
cord-006229-7yoilsho	4815	24	50	50	CD
cord-006229-7yoilsho	4815	25	in	in	IN
cord-006229-7yoilsho	4815	26	the	the	DT
cord-006229-7yoilsho	4815	27	low	low	JJ
cord-006229-7yoilsho	4815	28	nanomolar	nanomolar	JJ
cord-006229-7yoilsho	4815	29	range	range	NN
cord-006229-7yoilsho	4815	30	.	.	.
cord-006229-7yoilsho	4816	1	This	this	DT
cord-006229-7yoilsho	4816	2	novel	novel	JJ
cord-006229-7yoilsho	4816	3	class	class	NN
cord-006229-7yoilsho	4816	4	of	of	IN
cord-006229-7yoilsho	4816	5	TPH	TPH	NNP
cord-006229-7yoilsho	4816	6	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	4816	7	could	could	MD
cord-006229-7yoilsho	4816	8	potentially	potentially	RB
cord-006229-7yoilsho	4816	9	be	be	VB
cord-006229-7yoilsho	4816	10	used	use	VBN
cord-006229-7yoilsho	4816	11	to	to	TO
cord-006229-7yoilsho	4816	12	treat	treat	VB
cord-006229-7yoilsho	4816	13	a	a	DT
cord-006229-7yoilsho	4816	14	variety	variety	NN
cord-006229-7yoilsho	4816	15	of	of	IN
cord-006229-7yoilsho	4816	16	disorders	disorder	NNS
cord-006229-7yoilsho	4816	17	with	with	IN
cord-006229-7yoilsho	4816	18	aberrant	aberrant	JJ
cord-006229-7yoilsho	4816	19	peripheral	peripheral	JJ
cord-006229-7yoilsho	4816	20	5-HT	5-ht	CD
cord-006229-7yoilsho	4816	21	signaling	signaling	NN
cord-006229-7yoilsho	4816	22	,	,	,
cord-006229-7yoilsho	4816	23	such	such	JJ
cord-006229-7yoilsho	4816	24	as	as	IN
cord-006229-7yoilsho	4816	25	gastrointestinal	gastrointestinal	JJ
cord-006229-7yoilsho	4816	26	disorders	disorder	NNS
cord-006229-7yoilsho	4816	27	(	(	-LRB-
cord-006229-7yoilsho	4816	28	e.g.	e.g.	DT
cord-006229-7yoilsho	4816	29	irritable	irritable	JJ
cord-006229-7yoilsho	4816	30	bowel	bowel	NN
cord-006229-7yoilsho	4816	31	syndrome	syndrome	NN
cord-006229-7yoilsho	4816	32	,	,	,
cord-006229-7yoilsho	4816	33	Crohn	Crohn	NNP
cord-006229-7yoilsho	4816	34	's	's	POS
cord-006229-7yoilsho	4816	35	disease	disease	NN
cord-006229-7yoilsho	4816	36	,	,	,
cord-006229-7yoilsho	4816	37	various	various	JJ
cord-006229-7yoilsho	4816	38	forms	form	NNS
cord-006229-7yoilsho	4816	39	of	of	IN
cord-006229-7yoilsho	4816	40	diarrhea	diarrhea	NN
cord-006229-7yoilsho	4816	41	)	)	-RRB-
cord-006229-7yoilsho	4816	42	,	,	,
cord-006229-7yoilsho	4816	43	cardiac	cardiac	JJ
cord-006229-7yoilsho	4816	44	valve	valve	NN
cord-006229-7yoilsho	4816	45	diseases	disease	NNS
cord-006229-7yoilsho	4816	46	,	,	,
cord-006229-7yoilsho	4816	47	pulmonary	pulmonary	JJ
cord-006229-7yoilsho	4816	48	hypertension	hypertension	NN
cord-006229-7yoilsho	4816	49	,	,	,
cord-006229-7yoilsho	4816	50	chronic	chronic	JJ
cord-006229-7yoilsho	4816	51	respiratory	respiratory	JJ
cord-006229-7yoilsho	4816	52	diseases	disease	NNS
cord-006229-7yoilsho	4816	53	and	and	CC
cord-006229-7yoilsho	4816	54	some	some	DT
cord-006229-7yoilsho	4816	55	neuroendocrine	neuroendocrine	JJ
cord-006229-7yoilsho	4816	56	(	(	-LRB-
cord-006229-7yoilsho	4816	57	carcinoid	carcinoid	NN
cord-006229-7yoilsho	4816	58	)	)	-RRB-
cord-006229-7yoilsho	4816	59	tumors	tumor	NNS
cord-006229-7yoilsho	4816	60	.	.	.
cord-006229-7yoilsho	4817	1	Primary	primary	JJ
cord-006229-7yoilsho	4817	2	hepatocellular	hepatocellular	JJ
cord-006229-7yoilsho	4817	3	carcinoma	carcinoma	NN
cord-006229-7yoilsho	4817	4	(	(	-LRB-
cord-006229-7yoilsho	4817	5	HCC	HCC	NNP
cord-006229-7yoilsho	4817	6	)	)	-RRB-
cord-006229-7yoilsho	4817	7	is	be	VBZ
cord-006229-7yoilsho	4817	8	the	the	DT
cord-006229-7yoilsho	4817	9	most	most	RBS
cord-006229-7yoilsho	4817	10	frequent	frequent	JJ
cord-006229-7yoilsho	4817	11	type	type	NN
cord-006229-7yoilsho	4817	12	of	of	IN
cord-006229-7yoilsho	4817	13	liver	liver	NN
cord-006229-7yoilsho	4817	14	cancer	cancer	NN
cord-006229-7yoilsho	4817	15	.	.	.
cord-006229-7yoilsho	4818	1	Therapeutic	therapeutic	JJ
cord-006229-7yoilsho	4818	2	options	option	NNS
cord-006229-7yoilsho	4818	3	are	be	VBP
cord-006229-7yoilsho	4818	4	rare	rare	JJ
cord-006229-7yoilsho	4818	5	.	.	.
cord-006229-7yoilsho	4819	1	Beside	beside	IN
cord-006229-7yoilsho	4819	2	Sorafenib	Sorafenib	NNP
cord-006229-7yoilsho	4819	3	,	,	,
cord-006229-7yoilsho	4819	4	a	a	DT
cord-006229-7yoilsho	4819	5	tyrosinkinase	tyrosinkinase	NN
cord-006229-7yoilsho	4819	6	inhibitor	inhibitor	NN
cord-006229-7yoilsho	4819	7	,	,	,
cord-006229-7yoilsho	4819	8	which	which	WDT
cord-006229-7yoilsho	4819	9	is	be	VBZ
cord-006229-7yoilsho	4819	10	only	only	RB
cord-006229-7yoilsho	4819	11	used	use	VBN
cord-006229-7yoilsho	4819	12	in	in	IN
cord-006229-7yoilsho	4819	13	end	end	JJ
cord-006229-7yoilsho	4819	14	stage	stage	NN
cord-006229-7yoilsho	4819	15	liver	liver	NN
cord-006229-7yoilsho	4819	16	cancer	cancer	NN
cord-006229-7yoilsho	4819	17	,	,	,
cord-006229-7yoilsho	4819	18	the	the	DT
cord-006229-7yoilsho	4819	19	surgical	surgical	JJ
cord-006229-7yoilsho	4819	20	intervention	intervention	NN
cord-006229-7yoilsho	4819	21	is	be	VBZ
cord-006229-7yoilsho	4819	22	the	the	DT
cord-006229-7yoilsho	4819	23	only	only	JJ
cord-006229-7yoilsho	4819	24	successful	successful	JJ
cord-006229-7yoilsho	4819	25	clinical	clinical	JJ
cord-006229-7yoilsho	4819	26	treatment	treatment	NN
cord-006229-7yoilsho	4819	27	option	option	NN
cord-006229-7yoilsho	4819	28	.	.	.
cord-006229-7yoilsho	4820	1	Hence	hence	RB
cord-006229-7yoilsho	4820	2	there	there	EX
cord-006229-7yoilsho	4820	3	is	be	VBZ
cord-006229-7yoilsho	4820	4	an	an	DT
cord-006229-7yoilsho	4820	5	urgent	urgent	JJ
cord-006229-7yoilsho	4820	6	need	need	NN
cord-006229-7yoilsho	4820	7	to	to	TO
cord-006229-7yoilsho	4820	8	develop	develop	VB
cord-006229-7yoilsho	4820	9	new	new	JJ
cord-006229-7yoilsho	4820	10	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	4820	11	strategies	strategy	NNS
cord-006229-7yoilsho	4820	12	and	and	CC
cord-006229-7yoilsho	4820	13	to	to	TO
cord-006229-7yoilsho	4820	14	identify	identify	VB
cord-006229-7yoilsho	4820	15	new	new	JJ
cord-006229-7yoilsho	4820	16	drugs	drug	NNS
cord-006229-7yoilsho	4820	17	for	for	IN
cord-006229-7yoilsho	4820	18	therapy	therapy	NN
cord-006229-7yoilsho	4820	19	of	of	IN
cord-006229-7yoilsho	4820	20	HCC	HCC	NNP
cord-006229-7yoilsho	4820	21	.	.	.
cord-006229-7yoilsho	4821	1	HCC	HCC	NNP
cord-006229-7yoilsho	4821	2	often	often	RB
cord-006229-7yoilsho	4821	3	arises	arise	VBZ
cord-006229-7yoilsho	4821	4	in	in	IN
cord-006229-7yoilsho	4821	5	fibrotic	fibrotic	JJ
cord-006229-7yoilsho	4821	6	or	or	CC
cord-006229-7yoilsho	4821	7	cirrhotic	cirrhotic	JJ
cord-006229-7yoilsho	4821	8	liver	liver	NN
cord-006229-7yoilsho	4821	9	,	,	,
cord-006229-7yoilsho	4821	10	which	which	WDT
cord-006229-7yoilsho	4821	11	is	be	VBZ
cord-006229-7yoilsho	4821	12	accompanied	accompany	VBN
cord-006229-7yoilsho	4821	13	by	by	IN
cord-006229-7yoilsho	4821	14	a	a	DT
cord-006229-7yoilsho	4821	15	change	change	NN
cord-006229-7yoilsho	4821	16	of	of	IN
cord-006229-7yoilsho	4821	17	the	the	DT
cord-006229-7yoilsho	4821	18	extracellular	extracellular	JJ
cord-006229-7yoilsho	4821	19	matrix	matrix	NN
cord-006229-7yoilsho	4821	20	(	(	-LRB-
cord-006229-7yoilsho	4821	21	ECM	ECM	NNP
cord-006229-7yoilsho	4821	22	)	)	-RRB-
cord-006229-7yoilsho	4821	23	composition	composition	NN
cord-006229-7yoilsho	4821	24	.	.	.
cord-006229-7yoilsho	4822	1	In	in	IN
cord-006229-7yoilsho	4822	2	addition	addition	NN
cord-006229-7yoilsho	4822	3	it	-PRON-	PRP
cord-006229-7yoilsho	4822	4	was	be	VBD
cord-006229-7yoilsho	4822	5	shown	show	VBN
cord-006229-7yoilsho	4822	6	that	that	IN
cord-006229-7yoilsho	4822	7	hepatoma	hepatoma	NNP
cord-006229-7yoilsho	4822	8	cells	cell	NNS
cord-006229-7yoilsho	4822	9	express	express	VBP
cord-006229-7yoilsho	4822	10	different	different	JJ
cord-006229-7yoilsho	4822	11	integrins	integrin	NNS
cord-006229-7yoilsho	4822	12	,	,	,
cord-006229-7yoilsho	4822	13	which	which	WDT
cord-006229-7yoilsho	4822	14	interact	interact	VBP
cord-006229-7yoilsho	4822	15	with	with	IN
cord-006229-7yoilsho	4822	16	ECM	ECM	NNP
cord-006229-7yoilsho	4822	17	and	and	CC
cord-006229-7yoilsho	4822	18	intracellular	intracellular	JJ
cord-006229-7yoilsho	4822	19	cell	cell	NN
cord-006229-7yoilsho	4822	20	signaling	signaling	NN
cord-006229-7yoilsho	4822	21	,	,	,
cord-006229-7yoilsho	4822	22	compared	compare	VBN
cord-006229-7yoilsho	4822	23	to	to	IN
cord-006229-7yoilsho	4822	24	hepatocytes	hepatocyte	NNS
cord-006229-7yoilsho	4822	25	.	.	.
cord-006229-7yoilsho	4823	1	Snake	snake	NN
cord-006229-7yoilsho	4823	2	venoms	venom	NNS
cord-006229-7yoilsho	4823	3	have	have	VBP
cord-006229-7yoilsho	4823	4	gained	gain	VBN
cord-006229-7yoilsho	4823	5	increased	increase	VBN
cord-006229-7yoilsho	4823	6	attention	attention	NN
cord-006229-7yoilsho	4823	7	,	,	,
cord-006229-7yoilsho	4823	8	as	as	IN
cord-006229-7yoilsho	4823	9	it	-PRON-	PRP
cord-006229-7yoilsho	4823	10	was	be	VBD
cord-006229-7yoilsho	4823	11	shown	show	VBN
cord-006229-7yoilsho	4823	12	that	that	IN
cord-006229-7yoilsho	4823	13	some	some	DT
cord-006229-7yoilsho	4823	14	of	of	IN
cord-006229-7yoilsho	4823	15	their	-PRON-	PRP$
cord-006229-7yoilsho	4823	16	enzymes	enzyme	NNS
cord-006229-7yoilsho	4823	17	and	and	CC
cord-006229-7yoilsho	4823	18	peptides	peptide	NNS
cord-006229-7yoilsho	4823	19	directly	directly	RB
cord-006229-7yoilsho	4823	20	act	act	VBP
cord-006229-7yoilsho	4823	21	on	on	IN
cord-006229-7yoilsho	4823	22	tumor	tumor	NN
cord-006229-7yoilsho	4823	23	cells	cell	NNS
cord-006229-7yoilsho	4823	24	and	and	CC
cord-006229-7yoilsho	4823	25	their	-PRON-	PRP$
cord-006229-7yoilsho	4823	26	multicellular	multicellular	JJ
cord-006229-7yoilsho	4823	27	arrangement	arrangement	NN
cord-006229-7yoilsho	4823	28	or	or	CC
cord-006229-7yoilsho	4823	29	indirectly	indirectly	RB
cord-006229-7yoilsho	4823	30	by	by	IN
cord-006229-7yoilsho	4823	31	influencing	influence	VBG
cord-006229-7yoilsho	4823	32	the	the	DT
cord-006229-7yoilsho	4823	33	stroma	stroma	NN
cord-006229-7yoilsho	4823	34	environment	environment	NN
cord-006229-7yoilsho	4823	35	of	of	IN
cord-006229-7yoilsho	4823	36	the	the	DT
cord-006229-7yoilsho	4823	37	tumor	tumor	NN
cord-006229-7yoilsho	4823	38	.	.	.
cord-006229-7yoilsho	4824	1	Aim	aim	VB
cord-006229-7yoilsho	4824	2	of	of	IN
cord-006229-7yoilsho	4824	3	the	the	DT
cord-006229-7yoilsho	4824	4	present	present	JJ
cord-006229-7yoilsho	4824	5	study	study	NN
cord-006229-7yoilsho	4824	6	was	be	VBD
cord-006229-7yoilsho	4824	7	to	to	TO
cord-006229-7yoilsho	4824	8	investigate	investigate	VB
cord-006229-7yoilsho	4824	9	the	the	DT
cord-006229-7yoilsho	4824	10	effect	effect	NN
cord-006229-7yoilsho	4824	11	of	of	IN
cord-006229-7yoilsho	4824	12	snake	snake	NN
cord-006229-7yoilsho	4824	13	venoms	venom	NNS
cord-006229-7yoilsho	4824	14	on	on	IN
cord-006229-7yoilsho	4824	15	liver	liver	NN
cord-006229-7yoilsho	4824	16	cancer	cancer	NN
cord-006229-7yoilsho	4824	17	related	relate	VBN
cord-006229-7yoilsho	4824	18	cell	cell	NN
cord-006229-7yoilsho	4824	19	lines	line	NNS
cord-006229-7yoilsho	4824	20	as	as	RB
cord-006229-7yoilsho	4824	21	well	well	RB
cord-006229-7yoilsho	4824	22	as	as	IN
cord-006229-7yoilsho	4824	23	their	-PRON-	PRP$
cord-006229-7yoilsho	4824	24	specific	specific	JJ
cord-006229-7yoilsho	4824	25	action	action	NN
cord-006229-7yoilsho	4824	26	on	on	IN
cord-006229-7yoilsho	4824	27	the	the	DT
cord-006229-7yoilsho	4824	28	ECM	ECM	NNP
cord-006229-7yoilsho	4824	29	-	-	HYPH
cord-006229-7yoilsho	4824	30	integrin	integrin	NN
cord-006229-7yoilsho	4824	31	axis	axis	NN
cord-006229-7yoilsho	4824	32	.	.	.
cord-006229-7yoilsho	4825	1	The	the	DT
cord-006229-7yoilsho	4825	2	effects	effect	NNS
cord-006229-7yoilsho	4825	3	of	of	IN
cord-006229-7yoilsho	4825	4	the	the	DT
cord-006229-7yoilsho	4825	5	snake	snake	NN
cord-006229-7yoilsho	4825	6	venoms	venom	NNS
cord-006229-7yoilsho	4825	7	Vipera	Vipera	NNP
cord-006229-7yoilsho	4825	8	palestinae	palestinae	NN
cord-006229-7yoilsho	4825	9	(	(	-LRB-
cord-006229-7yoilsho	4825	10	VP	VP	NNP
cord-006229-7yoilsho	4825	11	)	)	-RRB-
cord-006229-7yoilsho	4825	12	,	,	,
cord-006229-7yoilsho	4825	13	Calloselasma	Calloselasma	NNP
cord-006229-7yoilsho	4825	14	rhodostoma	rhodostoma	NNP
cord-006229-7yoilsho	4825	15	(	(	-LRB-
cord-006229-7yoilsho	4825	16	CR	CR	NNP
cord-006229-7yoilsho	4825	17	)	)	-RRB-
cord-006229-7yoilsho	4825	18	and	and	CC
cord-006229-7yoilsho	4825	19	Echis	Echis	NNP
cord-006229-7yoilsho	4825	20	sochureki	sochureki	NNP
cord-006229-7yoilsho	4825	21	(	(	-LRB-
cord-006229-7yoilsho	4825	22	ES	ES	NNP
cord-006229-7yoilsho	4825	23	)	)	-RRB-
cord-006229-7yoilsho	4825	24	on	on	IN
cord-006229-7yoilsho	4825	25	a	a	DT
cord-006229-7yoilsho	4825	26	cellular	cellular	JJ
cord-006229-7yoilsho	4825	27	level	level	NN
cord-006229-7yoilsho	4825	28	(	(	-LRB-
cord-006229-7yoilsho	4825	29	MTT	MTT	NNP
cord-006229-7yoilsho	4825	30	,	,	,
cord-006229-7yoilsho	4825	31	LDH	LDH	NNP
cord-006229-7yoilsho	4825	32	release	release	NN
cord-006229-7yoilsho	4825	33	)	)	-RRB-
cord-006229-7yoilsho	4825	34	,	,	,
cord-006229-7yoilsho	4825	35	on	on	IN
cord-006229-7yoilsho	4825	36	cell	cell	NN
cord-006229-7yoilsho	4825	37	-	-	HYPH
cord-006229-7yoilsho	4825	38	cellconnections	cellconnection	NNS
cord-006229-7yoilsho	4825	39	(	(	-LRB-
cord-006229-7yoilsho	4825	40	Caco2	Caco2	VBN
cord-006229-7yoilsho	4825	41	permeability	permeability	NN
cord-006229-7yoilsho	4825	42	assay	assay	NN
cord-006229-7yoilsho	4825	43	)	)	-RRB-
cord-006229-7yoilsho	4825	44	and	and	CC
cord-006229-7yoilsho	4825	45	on	on	IN
cord-006229-7yoilsho	4825	46	cell	cell	NN
cord-006229-7yoilsho	4825	47	-	-	HYPH
cord-006229-7yoilsho	4825	48	matrix	matrix	NN
cord-006229-7yoilsho	4825	49	-	-	HYPH
cord-006229-7yoilsho	4825	50	interactions	interaction	NNS
cord-006229-7yoilsho	4825	51	(	(	-LRB-
cord-006229-7yoilsho	4825	52	adherence	adherence	NN
cord-006229-7yoilsho	4825	53	test	test	NN
cord-006229-7yoilsho	4825	54	)	)	-RRB-
cord-006229-7yoilsho	4825	55	were	be	VBD
cord-006229-7yoilsho	4825	56	investigated	investigate	VBN
cord-006229-7yoilsho	4825	57	.	.	.
cord-006229-7yoilsho	4826	1	Cell	cell	NN
cord-006229-7yoilsho	4826	2	-	-	HYPH
cord-006229-7yoilsho	4826	3	matrix	matrix	NN
cord-006229-7yoilsho	4826	4	interactions	interaction	NNS
cord-006229-7yoilsho	4826	5	were	be	VBD
cord-006229-7yoilsho	4826	6	tested	test	VBN
cord-006229-7yoilsho	4826	7	with	with	IN
cord-006229-7yoilsho	4826	8	an	an	DT
cord-006229-7yoilsho	4826	9	adhesion	adhesion	NN
cord-006229-7yoilsho	4826	10	assay	assay	NN
cord-006229-7yoilsho	4826	11	using	use	VBG
cord-006229-7yoilsho	4826	12	collagen	collagen	NN
cord-006229-7yoilsho	4826	13	I	I	NNP
cord-006229-7yoilsho	4826	14	(	(	-LRB-
cord-006229-7yoilsho	4826	15	c	c	NN
cord-006229-7yoilsho	4826	16	-	-	:
cord-006229-7yoilsho	4826	17	I	I	NNP
cord-006229-7yoilsho	4826	18	)	)	-RRB-
cord-006229-7yoilsho	4826	19	,	,	,
cord-006229-7yoilsho	4826	20	collagen	collagen	NNP
cord-006229-7yoilsho	4826	21	IV	IV	NNP
cord-006229-7yoilsho	4826	22	(	(	-LRB-
cord-006229-7yoilsho	4826	23	c	c	NNP
cord-006229-7yoilsho	4826	24	-	-	HYPH
cord-006229-7yoilsho	4826	25	IV	IV	NNP
cord-006229-7yoilsho	4826	26	)	)	-RRB-
cord-006229-7yoilsho	4826	27	,	,	,
cord-006229-7yoilsho	4826	28	fibronectin	fibronectin	NN
cord-006229-7yoilsho	4826	29	(	(	-LRB-
cord-006229-7yoilsho	4826	30	Fn	Fn	NNP
cord-006229-7yoilsho	4826	31	)	)	-RRB-
cord-006229-7yoilsho	4826	32	and	and	CC
cord-006229-7yoilsho	4826	33	laminin	laminin	NNP
cord-006229-7yoilsho	4826	34	(	(	-LRB-
cord-006229-7yoilsho	4826	35	Lm	Lm	NNP
cord-006229-7yoilsho	4826	36	)	)	-RRB-
cord-006229-7yoilsho	4826	37	as	as	IN
cord-006229-7yoilsho	4826	38	ECM	ECM	NNP
cord-006229-7yoilsho	4826	39	compounds	compound	NNS
cord-006229-7yoilsho	4826	40	.	.	.
cord-006229-7yoilsho	4827	1	In	in	IN
cord-006229-7yoilsho	4827	2	our	-PRON-	PRP$
cord-006229-7yoilsho	4827	3	in	in	FW
cord-006229-7yoilsho	4827	4	vitro	vitro	FW
cord-006229-7yoilsho	4827	5	models	model	NNS
cord-006229-7yoilsho	4827	6	we	-PRON-	PRP
cord-006229-7yoilsho	4827	7	used	use	VBD
cord-006229-7yoilsho	4827	8	HepG2	HepG2	NNP
cord-006229-7yoilsho	4827	9	as	as	IN
cord-006229-7yoilsho	4827	10	a	a	DT
cord-006229-7yoilsho	4827	11	HCC	HCC	NNP
cord-006229-7yoilsho	4827	12	tumor	tumor	NN
cord-006229-7yoilsho	4827	13	cell	cell	NN
cord-006229-7yoilsho	4827	14	line	line	NN
cord-006229-7yoilsho	4827	15	and	and	CC
cord-006229-7yoilsho	4827	16	the	the	DT
cord-006229-7yoilsho	4827	17	fibroblast	fibroblast	NN
cord-006229-7yoilsho	4827	18	cell	cell	NN
cord-006229-7yoilsho	4827	19	line	line	NN
cord-006229-7yoilsho	4827	20	Fi301	fi301	NN
cord-006229-7yoilsho	4827	21	as	as	IN
cord-006229-7yoilsho	4827	22	stroma	stroma	NN
cord-006229-7yoilsho	4827	23	simulation	simulation	NN
cord-006229-7yoilsho	4827	24	.	.	.
cord-006229-7yoilsho	4828	1	Additionally	additionally	RB
cord-006229-7yoilsho	4828	2	Caco2	Caco2	VBN
cord-006229-7yoilsho	4828	3	cells	cell	NNS
cord-006229-7yoilsho	4828	4	were	be	VBD
cord-006229-7yoilsho	4828	5	used	use	VBN
cord-006229-7yoilsho	4828	6	,	,	,
cord-006229-7yoilsho	4828	7	a	a	DT
cord-006229-7yoilsho	4828	8	colon	colon	NN
cord-006229-7yoilsho	4828	9	carcinoma	carcinoma	NN
cord-006229-7yoilsho	4828	10	cell	cell	NN
cord-006229-7yoilsho	4828	11	line	line	NN
cord-006229-7yoilsho	4828	12	representing	represent	VBG
cord-006229-7yoilsho	4828	13	colorectal	colorectal	JJ
cord-006229-7yoilsho	4828	14	liver	liver	NN
cord-006229-7yoilsho	4828	15	metastasis	metastasis	NN
cord-006229-7yoilsho	4828	16	.	.	.
cord-006229-7yoilsho	4829	1	The	the	DT
cord-006229-7yoilsho	4829	2	toxicity	toxicity	NN
cord-006229-7yoilsho	4829	3	of	of	IN
cord-006229-7yoilsho	4829	4	snake	snake	NN
cord-006229-7yoilsho	4829	5	venom	venom	NN
cord-006229-7yoilsho	4829	6	on	on	IN
cord-006229-7yoilsho	4829	7	liver	liver	NN
cord-006229-7yoilsho	4829	8	cancer	cancer	NN
cord-006229-7yoilsho	4829	9	related	relate	VBN
cord-006229-7yoilsho	4829	10	cell	cell	NN
cord-006229-7yoilsho	4829	11	lines	line	NNS
cord-006229-7yoilsho	4829	12	was	be	VBD
cord-006229-7yoilsho	4829	13	determined	determine	VBN
cord-006229-7yoilsho	4829	14	in	in	IN
cord-006229-7yoilsho	4829	15	the	the	DT
cord-006229-7yoilsho	4829	16	range	range	NN
cord-006229-7yoilsho	4829	17	of	of	IN
cord-006229-7yoilsho	4829	18	0.01	0.01	CD
cord-006229-7yoilsho	4829	19	-100	-100	NN
cord-006229-7yoilsho	4830	1	µg	µg	NNP
cord-006229-7yoilsho	4830	2	/	/	SYM
cord-006229-7yoilsho	4830	3	ml	ml	NNS
cord-006229-7yoilsho	4830	4	and	and	CC
cord-006229-7yoilsho	4830	5	plotted	plot	VBD
cord-006229-7yoilsho	4830	6	into	into	IN
cord-006229-7yoilsho	4830	7	dose	dose	JJ
cord-006229-7yoilsho	4830	8	response	response	NN
cord-006229-7yoilsho	4830	9	curves	curve	NNS
cord-006229-7yoilsho	4830	10	.	.	.
cord-006229-7yoilsho	4831	1	The	the	DT
cord-006229-7yoilsho	4831	2	NOAELs	noael	NNS
cord-006229-7yoilsho	4831	3	were	be	VBD
cord-006229-7yoilsho	4831	4	calculated	calculate	VBN
cord-006229-7yoilsho	4831	5	from	from	IN
cord-006229-7yoilsho	4831	6	these	these	DT
cord-006229-7yoilsho	4831	7	dose	dose	JJ
cord-006229-7yoilsho	4831	8	response	response	NN
cord-006229-7yoilsho	4831	9	curves	curve	NNS
cord-006229-7yoilsho	4831	10	:	:	:
cord-006229-7yoilsho	4832	1	VP	VP	NNP
cord-006229-7yoilsho	4832	2	:	:	:
cord-006229-7yoilsho	4832	3	0.5	0.5	CD
cord-006229-7yoilsho	4832	4	µg	µg	NN
cord-006229-7yoilsho	4832	5	/	/	SYM
cord-006229-7yoilsho	4832	6	ml	ml	NN
cord-006229-7yoilsho	4833	1	-CR	-CR	NNS
cord-006229-7yoilsho	4833	2	:	:	:
cord-006229-7yoilsho	4834	1	1	1	CD
cord-006229-7yoilsho	4834	2	µg	µg	NN
cord-006229-7yoilsho	4834	3	/	/	SYM
cord-006229-7yoilsho	4834	4	ml	ml	NN
cord-006229-7yoilsho	4835	1	-ES	-es	LS
cord-006229-7yoilsho	4835	2	:	:	:
cord-006229-7yoilsho	4836	1	5	5	CD
cord-006229-7yoilsho	4836	2	µg	µg	NN
cord-006229-7yoilsho	4836	3	/	/	SYM
cord-006229-7yoilsho	4836	4	ml	ml	NN
cord-006229-7yoilsho	4836	5	.	.	.
cord-006229-7yoilsho	4837	1	Performance	performance	NN
cord-006229-7yoilsho	4837	2	of	of	IN
cord-006229-7yoilsho	4837	3	the	the	DT
cord-006229-7yoilsho	4837	4	Caco2-Transwell	Caco2-Transwell	NNP
cord-006229-7yoilsho	4837	5	permeability	permeability	NN
cord-006229-7yoilsho	4837	6	assay	assay	NN
cord-006229-7yoilsho	4837	7	revealed	reveal	VBD
cord-006229-7yoilsho	4837	8	no	no	DT
cord-006229-7yoilsho	4837	9	influence	influence	NN
cord-006229-7yoilsho	4837	10	of	of	IN
cord-006229-7yoilsho	4837	11	the	the	DT
cord-006229-7yoilsho	4837	12	tested	test	VBN
cord-006229-7yoilsho	4837	13	venom	venom	NN
cord-006229-7yoilsho	4837	14	concentrations	concentration	NNS
cord-006229-7yoilsho	4837	15	on	on	IN
cord-006229-7yoilsho	4837	16	the	the	DT
cord-006229-7yoilsho	4837	17	integrity	integrity	NN
cord-006229-7yoilsho	4837	18	of	of	IN
cord-006229-7yoilsho	4837	19	the	the	DT
cord-006229-7yoilsho	4837	20	cellular	cellular	JJ
cord-006229-7yoilsho	4837	21	arrangement	arrangement	NN
cord-006229-7yoilsho	4837	22	.	.	.
cord-006229-7yoilsho	4838	1	Investigations	investigation	NNS
cord-006229-7yoilsho	4838	2	for	for	IN
cord-006229-7yoilsho	4838	3	integrin	integrin	JJ
cord-006229-7yoilsho	4838	4	inhibition	inhibition	NN
cord-006229-7yoilsho	4838	5	revealed	reveal	VBD
cord-006229-7yoilsho	4838	6	that	that	IN
cord-006229-7yoilsho	4838	7	the	the	DT
cord-006229-7yoilsho	4838	8	venom	venom	NN
cord-006229-7yoilsho	4838	9	from	from	IN
cord-006229-7yoilsho	4838	10	VP	VP	NNP
cord-006229-7yoilsho	4838	11	reduced	reduce	VBN
cord-006229-7yoilsho	4838	12	adherence	adherence	NN
cord-006229-7yoilsho	4838	13	on	on	IN
cord-006229-7yoilsho	4838	14	Lm	Lm	NNP
cord-006229-7yoilsho	4838	15	coated	coat	VBN
cord-006229-7yoilsho	4838	16	plates	plate	NNS
cord-006229-7yoilsho	4838	17	and	and	CC
cord-006229-7yoilsho	4838	18	the	the	DT
cord-006229-7yoilsho	4838	19	venom	venom	NN
cord-006229-7yoilsho	4838	20	of	of	IN
cord-006229-7yoilsho	4838	21	EC	EC	NNP
cord-006229-7yoilsho	4838	22	reduced	reduce	VBN
cord-006229-7yoilsho	4838	23	adherence	adherence	NN
cord-006229-7yoilsho	4838	24	on	on	IN
cord-006229-7yoilsho	4838	25	Lm	Lm	NNP
cord-006229-7yoilsho	4838	26	and	and	CC
cord-006229-7yoilsho	4838	27	Fn	Fn	NNP
cord-006229-7yoilsho	4838	28	coated	coated	JJ
cord-006229-7yoilsho	4838	29	plates	plate	NNS
cord-006229-7yoilsho	4838	30	compared	compare	VBN
cord-006229-7yoilsho	4838	31	to	to	IN
cord-006229-7yoilsho	4838	32	untreated	untreated	JJ
cord-006229-7yoilsho	4838	33	cells	cell	NNS
cord-006229-7yoilsho	4838	34	.	.	.
cord-006229-7yoilsho	4839	1	There	there	EX
cord-006229-7yoilsho	4839	2	was	be	VBD
cord-006229-7yoilsho	4839	3	no	no	DT
cord-006229-7yoilsho	4839	4	effect	effect	NN
cord-006229-7yoilsho	4839	5	on	on	IN
cord-006229-7yoilsho	4839	6	the	the	DT
cord-006229-7yoilsho	4839	7	adherence	adherence	NN
cord-006229-7yoilsho	4839	8	on	on	IN
cord-006229-7yoilsho	4839	9	any	any	DT
cord-006229-7yoilsho	4839	10	matrix	matrix	NN
cord-006229-7yoilsho	4839	11	from	from	IN
cord-006229-7yoilsho	4839	12	the	the	DT
cord-006229-7yoilsho	4839	13	venom	venom	NN
cord-006229-7yoilsho	4839	14	of	of	IN
cord-006229-7yoilsho	4839	15	CR	cr	NN
cord-006229-7yoilsho	4839	16	observable	observable	JJ
cord-006229-7yoilsho	4839	17	.	.	.
cord-006229-7yoilsho	4840	1	Co	co	NN
cord-006229-7yoilsho	4840	2	-	-	NN
cord-006229-7yoilsho	4840	3	incubation	incubation	NN
cord-006229-7yoilsho	4840	4	of	of	IN
cord-006229-7yoilsho	4840	5	the	the	DT
cord-006229-7yoilsho	4840	6	snake	snake	NN
cord-006229-7yoilsho	4840	7	venoms	venom	NNS
cord-006229-7yoilsho	4840	8	of	of	IN
cord-006229-7yoilsho	4840	9	VP	VP	NNP
cord-006229-7yoilsho	4840	10	and	and	CC
cord-006229-7yoilsho	4840	11	ES	ES	NNP
cord-006229-7yoilsho	4840	12	(	(	-LRB-
cord-006229-7yoilsho	4840	13	below	below	IN
cord-006229-7yoilsho	4840	14	or	or	CC
cord-006229-7yoilsho	4840	15	near	near	IN
cord-006229-7yoilsho	4840	16	NOAEL	NOAEL	NNP
cord-006229-7yoilsho	4840	17	concentrations	concentration	NNS
cord-006229-7yoilsho	4840	18	)	)	-RRB-
cord-006229-7yoilsho	4840	19	with	with	IN
cord-006229-7yoilsho	4840	20	5-Fluorouracil	5-fluorouracil	CD
cord-006229-7yoilsho	4840	21	(	(	-LRB-
cord-006229-7yoilsho	4840	22	5FU	5fu	CD
cord-006229-7yoilsho	4840	23	)	)	-RRB-
cord-006229-7yoilsho	4840	24	,	,	,
cord-006229-7yoilsho	4840	25	which	which	WDT
cord-006229-7yoilsho	4840	26	is	be	VBZ
cord-006229-7yoilsho	4840	27	used	use	VBN
cord-006229-7yoilsho	4840	28	as	as	IN
cord-006229-7yoilsho	4840	29	a	a	DT
cord-006229-7yoilsho	4840	30	chemotherapeutic	chemotherapeutic	JJ
cord-006229-7yoilsho	4840	31	agent	agent	NN
cord-006229-7yoilsho	4840	32	,	,	,
cord-006229-7yoilsho	4840	33	caused	cause	VBD
cord-006229-7yoilsho	4840	34	a	a	DT
cord-006229-7yoilsho	4840	35	reduction	reduction	NN
cord-006229-7yoilsho	4840	36	of	of	IN
cord-006229-7yoilsho	4840	37	its	-PRON-	PRP$
cord-006229-7yoilsho	4840	38	IC50	ic50	JJ
cord-006229-7yoilsho	4840	39	values	value	NNS
cord-006229-7yoilsho	4840	40	.	.	.
cord-006229-7yoilsho	4841	1	The	the	DT
cord-006229-7yoilsho	4841	2	results	result	NNS
cord-006229-7yoilsho	4841	3	indicate	indicate	VBP
cord-006229-7yoilsho	4841	4	that	that	IN
cord-006229-7yoilsho	4841	5	components	component	NNS
cord-006229-7yoilsho	4841	6	of	of	IN
cord-006229-7yoilsho	4841	7	VP	VP	NNP
cord-006229-7yoilsho	4841	8	and	and	CC
cord-006229-7yoilsho	4841	9	EC	EC	NNP
cord-006229-7yoilsho	4841	10	inhibit	inhibit	VBP
cord-006229-7yoilsho	4841	11	the	the	DT
cord-006229-7yoilsho	4841	12	formation	formation	NN
cord-006229-7yoilsho	4841	13	of	of	IN
cord-006229-7yoilsho	4841	14	cell	cell	NN
cord-006229-7yoilsho	4841	15	-	-	HYPH
cord-006229-7yoilsho	4841	16	matrixinteractions	matrixinteraction	NNS
cord-006229-7yoilsho	4841	17	possibly	possibly	RB
cord-006229-7yoilsho	4841	18	acting	act	VBG
cord-006229-7yoilsho	4841	19	as	as	IN
cord-006229-7yoilsho	4841	20	disintegrins	disintegrin	NNS
cord-006229-7yoilsho	4841	21	.	.	.
cord-006229-7yoilsho	4842	1	The	the	DT
cord-006229-7yoilsho	4842	2	co	co	NN
cord-006229-7yoilsho	4842	3	-	-	NN
cord-006229-7yoilsho	4842	4	incubation	incubation	JJ
cord-006229-7yoilsho	4842	5	experiments	experiment	NNS
cord-006229-7yoilsho	4842	6	demonstrated	demonstrate	VBD
cord-006229-7yoilsho	4842	7	a	a	DT
cord-006229-7yoilsho	4842	8	synergistic	synergistic	JJ
cord-006229-7yoilsho	4842	9	effect	effect	NN
cord-006229-7yoilsho	4842	10	of	of	IN
cord-006229-7yoilsho	4842	11	5FU	5fu	CD
cord-006229-7yoilsho	4842	12	and	and	CC
cord-006229-7yoilsho	4842	13	snake	snake	NN
cord-006229-7yoilsho	4842	14	venoms	venom	NNS
cord-006229-7yoilsho	4842	15	.	.	.
cord-006229-7yoilsho	4843	1	Further	further	JJ
cord-006229-7yoilsho	4843	2	experiments	experiment	NNS
cord-006229-7yoilsho	4843	3	should	should	MD
cord-006229-7yoilsho	4843	4	enable	enable	VB
cord-006229-7yoilsho	4843	5	the	the	DT
cord-006229-7yoilsho	4843	6	isolation	isolation	NN
cord-006229-7yoilsho	4843	7	of	of	IN
cord-006229-7yoilsho	4843	8	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	4843	9	active	active	JJ
cord-006229-7yoilsho	4843	10	venom	venom	NN
cord-006229-7yoilsho	4843	11	compounds	compound	NNS
cord-006229-7yoilsho	4843	12	,	,	,
cord-006229-7yoilsho	4843	13	identification	identification	NN
cord-006229-7yoilsho	4843	14	of	of	IN
cord-006229-7yoilsho	4843	15	disintegrins	disintegrin	NNS
cord-006229-7yoilsho	4843	16	and	and	CC
cord-006229-7yoilsho	4843	17	their	-PRON-	PRP$
cord-006229-7yoilsho	4843	18	role	role	NN
cord-006229-7yoilsho	4843	19	in	in	IN
cord-006229-7yoilsho	4843	20	synergistic	synergistic	JJ
cord-006229-7yoilsho	4843	21	mechanisms	mechanism	NNS
cord-006229-7yoilsho	4843	22	in	in	IN
cord-006229-7yoilsho	4843	23	liver	liver	NN
cord-006229-7yoilsho	4843	24	cancer	cancer	NN
cord-006229-7yoilsho	4843	25	therapy	therapy	NN
cord-006229-7yoilsho	4843	26	.	.	.
cord-006229-7yoilsho	4844	1	Modulation	modulation	NN
cord-006229-7yoilsho	4844	2	of	of	IN
cord-006229-7yoilsho	4844	3	the	the	DT
cord-006229-7yoilsho	4844	4	blood	blood	NN
cord-006229-7yoilsho	4844	5	-	-	HYPH
cord-006229-7yoilsho	4844	6	brain	brain	NN
cord-006229-7yoilsho	4844	7	barrier	barrier	NN
cord-006229-7yoilsho	4844	8	with	with	IN
cord-006229-7yoilsho	4844	9	peptidomimetics	peptidomimetic	NNS
cord-006229-7yoilsho	4844	10	to	to	TO
cord-006229-7yoilsho	4844	11	improve	improve	VB
cord-006229-7yoilsho	4844	12	drug	drug	NN
cord-006229-7yoilsho	4844	13	delivery	delivery	NN
cord-006229-7yoilsho	4844	14	S.	S.	NNP
cord-006229-7yoilsho	4844	15	Dithmer	Dithmer	NNP
cord-006229-7yoilsho	4844	16	After	after	IN
cord-006229-7yoilsho	4844	17	decades	decade	NNS
cord-006229-7yoilsho	4844	18	of	of	IN
cord-006229-7yoilsho	4844	19	research	research	NN
cord-006229-7yoilsho	4844	20	,	,	,
cord-006229-7yoilsho	4844	21	the	the	DT
cord-006229-7yoilsho	4844	22	blood	blood	NN
cord-006229-7yoilsho	4844	23	-	-	HYPH
cord-006229-7yoilsho	4844	24	brain	brain	NN
cord-006229-7yoilsho	4844	25	barrier	barrier	NN
cord-006229-7yoilsho	4844	26	(	(	-LRB-
cord-006229-7yoilsho	4844	27	BBB	BBB	NNP
cord-006229-7yoilsho	4844	28	)	)	-RRB-
cord-006229-7yoilsho	4844	29	still	still	RB
cord-006229-7yoilsho	4844	30	remains	remain	VBZ
cord-006229-7yoilsho	4844	31	a	a	DT
cord-006229-7yoilsho	4844	32	major	major	JJ
cord-006229-7yoilsho	4844	33	problem	problem	NN
cord-006229-7yoilsho	4844	34	for	for	IN
cord-006229-7yoilsho	4844	35	successful	successful	JJ
cord-006229-7yoilsho	4844	36	delivery	delivery	NN
cord-006229-7yoilsho	4844	37	to	to	IN
cord-006229-7yoilsho	4844	38	the	the	DT
cord-006229-7yoilsho	4844	39	brain	brain	NN
cord-006229-7yoilsho	4844	40	for	for	IN
cord-006229-7yoilsho	4844	41	the	the	DT
cord-006229-7yoilsho	4844	42	vast	vast	JJ
cord-006229-7yoilsho	4844	43	majority	majority	NN
cord-006229-7yoilsho	4844	44	of	of	IN
cord-006229-7yoilsho	4844	45	drugs	drug	NNS
cord-006229-7yoilsho	4844	46	.	.	.
cord-006229-7yoilsho	4845	1	The	the	DT
cord-006229-7yoilsho	4845	2	main	main	JJ
cord-006229-7yoilsho	4845	3	component	component	NN
cord-006229-7yoilsho	4845	4	forming	form	VBG
cord-006229-7yoilsho	4845	5	the	the	DT
cord-006229-7yoilsho	4845	6	BBB	BBB	NNP
cord-006229-7yoilsho	4845	7	is	be	VBZ
cord-006229-7yoilsho	4845	8	the	the	DT
cord-006229-7yoilsho	4845	9	brain	brain	NN
cord-006229-7yoilsho	4845	10	microvascular	microvascular	JJ
cord-006229-7yoilsho	4845	11	endothelium	endothelium	NN
cord-006229-7yoilsho	4845	12	.	.	.
cord-006229-7yoilsho	4846	1	The	the	DT
cord-006229-7yoilsho	4846	2	paracellular	paracellular	JJ
cord-006229-7yoilsho	4846	3	permeation	permeation	NN
cord-006229-7yoilsho	4846	4	is	be	VBZ
cord-006229-7yoilsho	4846	5	limited	limit	VBN
cord-006229-7yoilsho	4846	6	by	by	IN
cord-006229-7yoilsho	4846	7	tight	tight	JJ
cord-006229-7yoilsho	4846	8	junctions	junction	NNS
cord-006229-7yoilsho	4846	9	(	(	-LRB-
cord-006229-7yoilsho	4846	10	TJs	TJs	NNP
cord-006229-7yoilsho	4846	11	)	)	-RRB-
cord-006229-7yoilsho	4846	12	,	,	,
cord-006229-7yoilsho	4846	13	a	a	DT
cord-006229-7yoilsho	4846	14	multiprotein	multiprotein	NNP
cord-006229-7yoilsho	4846	15	complex	complex	NN
cord-006229-7yoilsho	4846	16	composed	compose	VBN
cord-006229-7yoilsho	4846	17	of	of	IN
cord-006229-7yoilsho	4846	18	the	the	DT
cord-006229-7yoilsho	4846	19	members	member	NNS
cord-006229-7yoilsho	4846	20	of	of	IN
cord-006229-7yoilsho	4846	21	the	the	DT
cord-006229-7yoilsho	4846	22	claudin	claudin	NNP
cord-006229-7yoilsho	4846	23	family	family	NN
cord-006229-7yoilsho	4846	24	claudin-1	claudin-1	NNP
cord-006229-7yoilsho	4846	25	,	,	,
cord-006229-7yoilsho	4847	1	-3	-3	NNP
cord-006229-7yoilsho	4847	2	,	,	,
cord-006229-7yoilsho	4848	1	-5	-5	NNP
cord-006229-7yoilsho	4848	2	,	,	,
cord-006229-7yoilsho	4849	1	-12	-12	FW
cord-006229-7yoilsho	4849	2	.	.	.
cord-006229-7yoilsho	4850	1	Claudin-5	Claudin-5	NNP
cord-006229-7yoilsho	4850	2	is	be	VBZ
cord-006229-7yoilsho	4850	3	known	know	VBN
cord-006229-7yoilsho	4850	4	to	to	TO
cord-006229-7yoilsho	4850	5	be	be	VB
cord-006229-7yoilsho	4850	6	the	the	DT
cord-006229-7yoilsho	4850	7	key	key	JJ
cord-006229-7yoilsho	4850	8	TJ	TJ	NNP
cord-006229-7yoilsho	4850	9	protein	protein	NN
cord-006229-7yoilsho	4850	10	tightening	tighten	VBG
cord-006229-7yoilsho	4850	11	the	the	DT
cord-006229-7yoilsho	4850	12	BBB	BBB	NNP
cord-006229-7yoilsho	4850	13	.	.	.
cord-006229-7yoilsho	4851	1	Therefore	therefore	RB
cord-006229-7yoilsho	4851	2	,	,	,
cord-006229-7yoilsho	4851	3	claudin-5	claudin-5	NNP
cord-006229-7yoilsho	4851	4	has	have	VBZ
cord-006229-7yoilsho	4851	5	been	be	VBN
cord-006229-7yoilsho	4851	6	selected	select	VBN
cord-006229-7yoilsho	4851	7	as	as	IN
cord-006229-7yoilsho	4851	8	target	target	NN
cord-006229-7yoilsho	4851	9	to	to	TO
cord-006229-7yoilsho	4851	10	modulate	modulate	VB
cord-006229-7yoilsho	4851	11	the	the	DT
cord-006229-7yoilsho	4851	12	BBB	BBB	NNP
cord-006229-7yoilsho	4851	13	.	.	.
cord-006229-7yoilsho	4852	1	For	for	IN
cord-006229-7yoilsho	4852	2	this	this	DT
cord-006229-7yoilsho	4852	3	reason	reason	NN
cord-006229-7yoilsho	4852	4	,	,	,
cord-006229-7yoilsho	4852	5	drug	drug	NN
cord-006229-7yoilsho	4852	6	enhancer	enhancer	NN
cord-006229-7yoilsho	4852	7	peptides	peptide	NNS
cord-006229-7yoilsho	4852	8	(	(	-LRB-
cord-006229-7yoilsho	4852	9	peptidomimetics	peptidomimetic	NNS
cord-006229-7yoilsho	4852	10	)	)	-RRB-
cord-006229-7yoilsho	4852	11	were	be	VBD
cord-006229-7yoilsho	4852	12	designed	design	VBN
cord-006229-7yoilsho	4852	13	to	to	TO
cord-006229-7yoilsho	4852	14	modulate	modulate	VB
cord-006229-7yoilsho	4852	15	transiently	transiently	RB
cord-006229-7yoilsho	4852	16	claudin-5	claudin-5	NNP
cord-006229-7yoilsho	4852	17	and	and	CC
cord-006229-7yoilsho	4852	18	,	,	,
cord-006229-7yoilsho	4852	19	thereby	thereby	RB
cord-006229-7yoilsho	4852	20	,	,	,
cord-006229-7yoilsho	4852	21	permeabilize	permeabilize	NNP
cord-006229-7yoilsho	4852	22	the	the	DT
cord-006229-7yoilsho	4852	23	BBB	BBB	NNP
cord-006229-7yoilsho	4852	24	.	.	.
cord-006229-7yoilsho	4853	1	By	by	IN
cord-006229-7yoilsho	4853	2	combining	combine	VBG
cord-006229-7yoilsho	4853	3	biochemical	biochemical	JJ
cord-006229-7yoilsho	4853	4	protein	protein	NN
cord-006229-7yoilsho	4853	5	/	/	SYM
cord-006229-7yoilsho	4853	6	peptide	peptide	NN
cord-006229-7yoilsho	4853	7	interaction	interaction	NN
cord-006229-7yoilsho	4853	8	and	and	CC
cord-006229-7yoilsho	4853	9	tissue	tissue	NN
cord-006229-7yoilsho	4853	10	culture	culture	NN
cord-006229-7yoilsho	4853	11	methods	method	NNS
cord-006229-7yoilsho	4853	12	,	,	,
cord-006229-7yoilsho	4853	13	we	-PRON-	PRP
cord-006229-7yoilsho	4853	14	identified	identify	VBD
cord-006229-7yoilsho	4853	15	,	,	,
cord-006229-7yoilsho	4853	16	validated	validate	VBD
cord-006229-7yoilsho	4853	17	and	and	CC
cord-006229-7yoilsho	4853	18	optimized	optimize	VBN
cord-006229-7yoilsho	4853	19	peptide	peptide	NN
cord-006229-7yoilsho	4853	20	sequences	sequence	NNS
cord-006229-7yoilsho	4853	21	modulating	modulate	VBG
cord-006229-7yoilsho	4853	22	claudin-5	claudin-5	NNP
cord-006229-7yoilsho	4853	23	containing	contain	VBG
cord-006229-7yoilsho	4853	24	barriers	barrier	NNS
cord-006229-7yoilsho	4853	25	.	.	.
cord-006229-7yoilsho	4854	1	The	the	DT
cord-006229-7yoilsho	4854	2	claudin-5	claudin-5	NNP
cord-006229-7yoilsho	4854	3	targeting	target	VBG
cord-006229-7yoilsho	4854	4	peptides	peptide	NNS
cord-006229-7yoilsho	4854	5	decreased	decrease	VBD
cord-006229-7yoilsho	4854	6	the	the	DT
cord-006229-7yoilsho	4854	7	transcellular	transcellular	JJ
cord-006229-7yoilsho	4854	8	electrical	electrical	JJ
cord-006229-7yoilsho	4854	9	resistance	resistance	NN
cord-006229-7yoilsho	4854	10	and	and	CC
cord-006229-7yoilsho	4854	11	increased	increase	VBD
cord-006229-7yoilsho	4854	12	the	the	DT
cord-006229-7yoilsho	4854	13	permeability	permeability	NN
cord-006229-7yoilsho	4854	14	through	through	IN
cord-006229-7yoilsho	4854	15	MDCK	MDCK	NNP
cord-006229-7yoilsho	4854	16	-	-	HYPH
cord-006229-7yoilsho	4854	17	II	II	NNP
cord-006229-7yoilsho	4854	18	cell	cell	NN
cord-006229-7yoilsho	4854	19	monolayers	monolayer	NNS
cord-006229-7yoilsho	4854	20	stably	stably	RB
cord-006229-7yoilsho	4854	21	expressing	express	VBG
cord-006229-7yoilsho	4854	22	YFPclaudin-5	YFPclaudin-5	NNS
cord-006229-7yoilsho	4854	23	and	and	CC
cord-006229-7yoilsho	4854	24	immortalized	immortalize	VBN
cord-006229-7yoilsho	4854	25	brain	brain	NN
cord-006229-7yoilsho	4854	26	endothelial	endothelial	NN
cord-006229-7yoilsho	4854	27	cells	cell	NNS
cord-006229-7yoilsho	4854	28	(	(	-LRB-
cord-006229-7yoilsho	4854	29	bEND.3	bend.3	CD
cord-006229-7yoilsho	4854	30	)	)	-RRB-
cord-006229-7yoilsho	4854	31	.	.	.
cord-006229-7yoilsho	4855	1	The	the	DT
cord-006229-7yoilsho	4855	2	peptides	peptide	NNS
cord-006229-7yoilsho	4855	3	decreased	decrease	VBD
cord-006229-7yoilsho	4855	4	the	the	DT
cord-006229-7yoilsho	4855	5	amount	amount	NN
cord-006229-7yoilsho	4855	6	of	of	IN
cord-006229-7yoilsho	4855	7	claudin-5	claudin-5	NNP
cord-006229-7yoilsho	4855	8	and	and	CC
cord-006229-7yoilsho	4855	9	ZO-1	ZO-1	NNP
cord-006229-7yoilsho	4855	10	at	at	IN
cord-006229-7yoilsho	4855	11	cell	cell	NN
cord-006229-7yoilsho	4855	12	-	-	HYPH
cord-006229-7yoilsho	4855	13	cell	cell	NN
cord-006229-7yoilsho	4855	14	contacts	contact	NNS
cord-006229-7yoilsho	4855	15	and	and	CC
cord-006229-7yoilsho	4855	16	changed	change	VBD
cord-006229-7yoilsho	4855	17	the	the	DT
cord-006229-7yoilsho	4855	18	cell	cell	NN
cord-006229-7yoilsho	4855	19	morphology	morphology	NN
cord-006229-7yoilsho	4855	20	from	from	IN
cord-006229-7yoilsho	4855	21	spindle	spindle	NN
cord-006229-7yoilsho	4855	22	-	-	HYPH
cord-006229-7yoilsho	4855	23	shaped	shape	VBN
cord-006229-7yoilsho	4855	24	to	to	IN
cord-006229-7yoilsho	4855	25	more	more	JJR
cord-006229-7yoilsho	4855	26	round	round	NN
cord-006229-7yoilsho	4855	27	-	-	HYPH
cord-006229-7yoilsho	4855	28	shaped	shaped	JJ
cord-006229-7yoilsho	4855	29	.	.	.
cord-006229-7yoilsho	4856	1	All	all	DT
cord-006229-7yoilsho	4856	2	tested	test	VBN
cord-006229-7yoilsho	4856	3	peptides	peptide	NNS
cord-006229-7yoilsho	4856	4	showed	show	VBD
cord-006229-7yoilsho	4856	5	no	no	DT
cord-006229-7yoilsho	4856	6	signs	sign	NNS
cord-006229-7yoilsho	4856	7	of	of	IN
cord-006229-7yoilsho	4856	8	toxicity	toxicity	NN
cord-006229-7yoilsho	4856	9	on	on	IN
cord-006229-7yoilsho	4856	10	cell	cell	NN
cord-006229-7yoilsho	4856	11	cultures	culture	NNS
cord-006229-7yoilsho	4856	12	and	and	CC
cord-006229-7yoilsho	4856	13	in	in	IN
cord-006229-7yoilsho	4856	14	vivo	vivo	FW
cord-006229-7yoilsho	4856	15	(	(	-LRB-
cord-006229-7yoilsho	4856	16	intravenous	intravenous	JJ
cord-006229-7yoilsho	4856	17	injection	injection	NN
cord-006229-7yoilsho	4856	18	)	)	-RRB-
cord-006229-7yoilsho	4856	19	.	.	.
cord-006229-7yoilsho	4857	1	Permeability	permeability	NN
cord-006229-7yoilsho	4857	2	measurements	measurement	NNS
cord-006229-7yoilsho	4857	3	in	in	IN
cord-006229-7yoilsho	4857	4	mice	mouse	NNS
cord-006229-7yoilsho	4857	5	proved	prove	VBD
cord-006229-7yoilsho	4857	6	enhanced	enhanced	JJ
cord-006229-7yoilsho	4857	7	permeation	permeation	NN
cord-006229-7yoilsho	4857	8	of	of	IN
cord-006229-7yoilsho	4857	9	Na	Na	NNP
cord-006229-7yoilsho	4857	10	-	-	HYPH
cord-006229-7yoilsho	4857	11	fluorescein	fluorescein	NNP
cord-006229-7yoilsho	4857	12	(	(	-LRB-
cord-006229-7yoilsho	4857	13	376	376	CD
cord-006229-7yoilsho	4857	14	Da	Da	NNP
cord-006229-7yoilsho	4857	15	)	)	-RRB-
cord-006229-7yoilsho	4857	16	through	through	IN
cord-006229-7yoilsho	4857	17	the	the	DT
cord-006229-7yoilsho	4857	18	BBB	BBB	NNP
cord-006229-7yoilsho	4857	19	,	,	,
cord-006229-7yoilsho	4857	20	which	which	WDT
cord-006229-7yoilsho	4857	21	was	be	VBD
cord-006229-7yoilsho	4857	22	confirmed	confirm	VBN
cord-006229-7yoilsho	4857	23	by	by	IN
cord-006229-7yoilsho	4857	24	magnet	magnet	NN
cord-006229-7yoilsho	4857	25	resonance	resonance	NN
cord-006229-7yoilsho	4857	26	imaging	imaging	NN
cord-006229-7yoilsho	4857	27	of	of	IN
cord-006229-7yoilsho	4857	28	contrast	contrast	NN
cord-006229-7yoilsho	4857	29	agents	agent	NNS
cord-006229-7yoilsho	4858	1	(	(	-LRB-
cord-006229-7yoilsho	4858	2	Gd	Gd	NNP
cord-006229-7yoilsho	4858	3	-	-	HYPH
cord-006229-7yoilsho	4858	4	DTPA	DTPA	NNP
cord-006229-7yoilsho	4858	5	,	,	,
cord-006229-7yoilsho	4858	6	547	547	CD
cord-006229-7yoilsho	4858	7	Da	Da	NNS
cord-006229-7yoilsho	4858	8	)	)	-RRB-
cord-006229-7yoilsho	4858	9	.	.	.
cord-006229-7yoilsho	4859	1	In	in	IN
cord-006229-7yoilsho	4859	2	summary	summary	NN
cord-006229-7yoilsho	4859	3	,	,	,
cord-006229-7yoilsho	4859	4	we	-PRON-	PRP
cord-006229-7yoilsho	4859	5	identified	identify	VBD
cord-006229-7yoilsho	4859	6	new	new	JJ
cord-006229-7yoilsho	4859	7	peptides	peptide	NNS
cord-006229-7yoilsho	4859	8	with	with	IN
cord-006229-7yoilsho	4859	9	the	the	DT
cord-006229-7yoilsho	4859	10	potential	potential	NN
cord-006229-7yoilsho	4859	11	to	to	TO
cord-006229-7yoilsho	4859	12	enhance	enhance	VB
cord-006229-7yoilsho	4859	13	cerebral	cerebral	JJ
cord-006229-7yoilsho	4859	14	delivery	delivery	NN
cord-006229-7yoilsho	4859	15	of	of	IN
cord-006229-7yoilsho	4859	16	small	small	JJ
cord-006229-7yoilsho	4859	17	molecules	molecule	NNS
cord-006229-7yoilsho	4859	18	through	through	IN
cord-006229-7yoilsho	4859	19	the	the	DT
cord-006229-7yoilsho	4859	20	BBB	BBB	NNP
cord-006229-7yoilsho	4859	21	.	.	.
cord-006229-7yoilsho	4860	1	Treatment	treatment	NN
cord-006229-7yoilsho	4860	2	of	of	IN
cord-006229-7yoilsho	4860	3	cerebral	cerebral	JJ
cord-006229-7yoilsho	4860	4	diseases	disease	NNS
cord-006229-7yoilsho	4860	5	is	be	VBZ
cord-006229-7yoilsho	4860	6	limited	limit	VBN
cord-006229-7yoilsho	4860	7	by	by	IN
cord-006229-7yoilsho	4860	8	the	the	DT
cord-006229-7yoilsho	4860	9	capability	capability	NN
cord-006229-7yoilsho	4860	10	of	of	IN
cord-006229-7yoilsho	4860	11	pharmacologically	pharmacologically	RB
cord-006229-7yoilsho	4860	12	active	active	JJ
cord-006229-7yoilsho	4860	13	agents	agent	NNS
cord-006229-7yoilsho	4860	14	to	to	TO
cord-006229-7yoilsho	4860	15	penetrate	penetrate	VB
cord-006229-7yoilsho	4860	16	the	the	DT
cord-006229-7yoilsho	4860	17	blood	blood	NN
cord-006229-7yoilsho	4860	18	-	-	HYPH
cord-006229-7yoilsho	4860	19	brain	brain	NN
cord-006229-7yoilsho	4860	20	barrier	barrier	NN
cord-006229-7yoilsho	4860	21	(	(	-LRB-
cord-006229-7yoilsho	4860	22	BBB	BBB	NNP
cord-006229-7yoilsho	4860	23	)	)	-RRB-
cord-006229-7yoilsho	4860	24	.	.	.
cord-006229-7yoilsho	4861	1	This	this	DT
cord-006229-7yoilsho	4861	2	paracellularly	paracellularly	RB
cord-006229-7yoilsho	4861	3	tight	tight	JJ
cord-006229-7yoilsho	4861	4	diffusion	diffusion	NN
cord-006229-7yoilsho	4861	5	barrier	barrier	NN
cord-006229-7yoilsho	4861	6	is	be	VBZ
cord-006229-7yoilsho	4861	7	formed	form	VBN
cord-006229-7yoilsho	4861	8	by	by	IN
cord-006229-7yoilsho	4861	9	brain	brain	NN
cord-006229-7yoilsho	4861	10	capillary	capillary	JJ
cord-006229-7yoilsho	4861	11	endothelial	endothelial	JJ
cord-006229-7yoilsho	4861	12	cells	cell	NNS
cord-006229-7yoilsho	4861	13	.	.	.
cord-006229-7yoilsho	4862	1	The	the	DT
cord-006229-7yoilsho	4862	2	paraendothelial	paraendothelial	JJ
cord-006229-7yoilsho	4862	3	cleft	cleft	NN
cord-006229-7yoilsho	4862	4	is	be	VBZ
cord-006229-7yoilsho	4862	5	sealed	seal	VBN
cord-006229-7yoilsho	4862	6	by	by	IN
cord-006229-7yoilsho	4862	7	tight	tight	JJ
cord-006229-7yoilsho	4862	8	junctions	junction	NNS
cord-006229-7yoilsho	4862	9	(	(	-LRB-
cord-006229-7yoilsho	4862	10	TJs	TJs	NNP
cord-006229-7yoilsho	4862	11	)	)	-RRB-
cord-006229-7yoilsho	4862	12	,	,	,
cord-006229-7yoilsho	4862	13	a	a	DT
cord-006229-7yoilsho	4862	14	multiprotein	multiprotein	NNP
cord-006229-7yoilsho	4862	15	complex	complex	NN
cord-006229-7yoilsho	4862	16	.	.	.
cord-006229-7yoilsho	4863	1	Cerebral	Cerebral	NNP
cord-006229-7yoilsho	4863	2	TJs	TJs	NNP
cord-006229-7yoilsho	4863	3	predominantly	predominantly	RB
cord-006229-7yoilsho	4863	4	consist	consist	VBP
cord-006229-7yoilsho	4863	5	of	of	IN
cord-006229-7yoilsho	4863	6	claudin-5	claudin-5	NNP
cord-006229-7yoilsho	4863	7	(	(	-LRB-
cord-006229-7yoilsho	4863	8	Cldn5	Cldn5	NNP
cord-006229-7yoilsho	4863	9	)	)	-RRB-
cord-006229-7yoilsho	4863	10	which	which	WDT
cord-006229-7yoilsho	4863	11	tightens	tighten	VBZ
cord-006229-7yoilsho	4863	12	the	the	DT
cord-006229-7yoilsho	4863	13	BBB	BBB	NNP
cord-006229-7yoilsho	4863	14	for	for	IN
cord-006229-7yoilsho	4863	15	molecules	molecule	NNS
cord-006229-7yoilsho	4863	16	<	<	XX
cord-006229-7yoilsho	4863	17	800	800	CD
cord-006229-7yoilsho	4863	18	Da	Da	NNP
cord-006229-7yoilsho	4863	19	.	.	.
cord-006229-7yoilsho	4864	1	Consequently	consequently	RB
cord-006229-7yoilsho	4864	2	,	,	,
cord-006229-7yoilsho	4864	3	Cldn5	Cldn5	NNP
cord-006229-7yoilsho	4864	4	is	be	VBZ
cord-006229-7yoilsho	4864	5	a	a	DT
cord-006229-7yoilsho	4864	6	potential	potential	JJ
cord-006229-7yoilsho	4864	7	target	target	NN
cord-006229-7yoilsho	4864	8	for	for	IN
cord-006229-7yoilsho	4864	9	transient	transient	JJ
cord-006229-7yoilsho	4864	10	and	and	CC
cord-006229-7yoilsho	4864	11	size	size	NN
cord-006229-7yoilsho	4864	12	-	-	HYPH
cord-006229-7yoilsho	4864	13	specific	specific	JJ
cord-006229-7yoilsho	4864	14	modulation	modulation	NN
cord-006229-7yoilsho	4864	15	of	of	IN
cord-006229-7yoilsho	4864	16	the	the	DT
cord-006229-7yoilsho	4864	17	BBB	BBB	NNP
cord-006229-7yoilsho	4864	18	to	to	TO
cord-006229-7yoilsho	4864	19	improve	improve	VB
cord-006229-7yoilsho	4864	20	CNS	CNS	NNP
cord-006229-7yoilsho	4864	21	penetration	penetration	NN
cord-006229-7yoilsho	4864	22	for	for	IN
cord-006229-7yoilsho	4864	23	pharmaceutically	pharmaceutically	RB
cord-006229-7yoilsho	4864	24	active	active	JJ
cord-006229-7yoilsho	4864	25	agents	agent	NNS
cord-006229-7yoilsho	4864	26	.	.	.
cord-006229-7yoilsho	4865	1	In	in	IN
cord-006229-7yoilsho	4865	2	high	high	JJ
cord-006229-7yoilsho	4865	3	throughput	throughput	NN
cord-006229-7yoilsho	4865	4	screening	screening	NN
cord-006229-7yoilsho	4865	5	using	use	VBG
cord-006229-7yoilsho	4865	6	a	a	DT
cord-006229-7yoilsho	4865	7	Cldn5	cldn5	JJ
cord-006229-7yoilsho	4865	8	assay	assay	NN
cord-006229-7yoilsho	4865	9	,	,	,
cord-006229-7yoilsho	4865	10	the	the	DT
cord-006229-7yoilsho	4865	11	barrier	barrier	NN
cord-006229-7yoilsho	4865	12	opener	opener	NN
cord-006229-7yoilsho	4865	13	1	1	CD
cord-006229-7yoilsho	4865	14	(	(	-LRB-
cord-006229-7yoilsho	4865	15	BO1	BO1	NNP
cord-006229-7yoilsho	4865	16	)	)	-RRB-
cord-006229-7yoilsho	4865	17	was	be	VBD
cord-006229-7yoilsho	4865	18	identified	identify	VBN
cord-006229-7yoilsho	4865	19	as	as	IN
cord-006229-7yoilsho	4865	20	a	a	DT
cord-006229-7yoilsho	4865	21	Cldn5	cldn5	JJ
cord-006229-7yoilsho	4865	22	modulator	modulator	NN
cord-006229-7yoilsho	4865	23	.	.	.
cord-006229-7yoilsho	4866	1	Initially	initially	RB
cord-006229-7yoilsho	4866	2	,	,	,
cord-006229-7yoilsho	4866	3	a	a	DT
cord-006229-7yoilsho	4866	4	significant	significant	JJ
cord-006229-7yoilsho	4866	5	removal	removal	NN
cord-006229-7yoilsho	4866	6	of	of	IN
cord-006229-7yoilsho	4866	7	Cldn5	Cldn5	NNP
cord-006229-7yoilsho	4866	8	from	from	IN
cord-006229-7yoilsho	4866	9	the	the	DT
cord-006229-7yoilsho	4866	10	plasma	plasma	NN
cord-006229-7yoilsho	4866	11	membrane	membrane	NN
cord-006229-7yoilsho	4866	12	was	be	VBD
cord-006229-7yoilsho	4866	13	shown	show	VBN
cord-006229-7yoilsho	4866	14	by	by	IN
cord-006229-7yoilsho	4866	15	confocal	confocal	JJ
cord-006229-7yoilsho	4866	16	microscopy	microscopy	NNS
cord-006229-7yoilsho	4866	17	using	use	VBG
cord-006229-7yoilsho	4866	18	epithelial	epithelial	JJ
cord-006229-7yoilsho	4866	19	and	and	CC
cord-006229-7yoilsho	4866	20	endothelial	endothelial	JJ
cord-006229-7yoilsho	4866	21	cell	cell	NN
cord-006229-7yoilsho	4866	22	lines	line	NNS
cord-006229-7yoilsho	4866	23	.	.	.
cord-006229-7yoilsho	4867	1	Measurement	Measurement	NNP
cord-006229-7yoilsho	4867	2	of	of	IN
cord-006229-7yoilsho	4867	3	transcellular	transcellular	JJ
cord-006229-7yoilsho	4867	4	electrical	electrical	JJ
cord-006229-7yoilsho	4867	5	resistance	resistance	NN
cord-006229-7yoilsho	4867	6	and	and	CC
cord-006229-7yoilsho	4867	7	of	of	IN
cord-006229-7yoilsho	4867	8	paracellular	paracellular	JJ
cord-006229-7yoilsho	4867	9	permeability	permeability	NN
cord-006229-7yoilsho	4867	10	using	use	VBG
cord-006229-7yoilsho	4867	11	lucifer	lucifer	NNP
cord-006229-7yoilsho	4867	12	yellow	yellow	NNP
cord-006229-7yoilsho	4867	13	(	(	-LRB-
cord-006229-7yoilsho	4867	14	mw	mw	NNP
cord-006229-7yoilsho	4867	15	521	521	CD
cord-006229-7yoilsho	4867	16	Da	Da	NNS
cord-006229-7yoilsho	4867	17	)	)	-RRB-
cord-006229-7yoilsho	4867	18	demonstrated	demonstrate	VBD
cord-006229-7yoilsho	4867	19	the	the	DT
cord-006229-7yoilsho	4867	20	effect	effect	NN
cord-006229-7yoilsho	4867	21	of	of	IN
cord-006229-7yoilsho	4867	22	BO1	BO1	NNP
cord-006229-7yoilsho	4867	23	.	.	.
cord-006229-7yoilsho	4868	1	Concentration	concentration	NN
cord-006229-7yoilsho	4868	2	dependent	dependent	JJ
cord-006229-7yoilsho	4868	3	treatment	treatment	NN
cord-006229-7yoilsho	4868	4	(	(	-LRB-
cord-006229-7yoilsho	4868	5	50	50	CD
cord-006229-7yoilsho	4868	6	-	-	SYM
cord-006229-7yoilsho	4868	7	150	150	CD
cord-006229-7yoilsho	4868	8	µM	µm	NN
cord-006229-7yoilsho	4868	9	)	)	-RRB-
cord-006229-7yoilsho	4868	10	of	of	IN
cord-006229-7yoilsho	4868	11	cell	cell	NN
cord-006229-7yoilsho	4868	12	monolayers	monolayer	NNS
cord-006229-7yoilsho	4868	13	with	with	IN
cord-006229-7yoilsho	4868	14	BO1	BO1	NNP
cord-006229-7yoilsho	4868	15	reduced	reduce	VBD
cord-006229-7yoilsho	4868	16	tightness	tightness	NN
cord-006229-7yoilsho	4868	17	of	of	IN
cord-006229-7yoilsho	4868	18	the	the	DT
cord-006229-7yoilsho	4868	19	TJs	tj	NNS
cord-006229-7yoilsho	4868	20	between	between	IN
cord-006229-7yoilsho	4868	21	some	some	DT
cord-006229-7yoilsho	4868	22	hours	hour	NNS
cord-006229-7yoilsho	4868	23	and	and	CC
cord-006229-7yoilsho	4868	24	24	24	CD
cord-006229-7yoilsho	4868	25	h.	h.	NN
cord-006229-7yoilsho	4869	1	Applying	apply	VBG
cord-006229-7yoilsho	4869	2	2-hydroxypropyl	2-hydroxypropyl	CD
cord-006229-7yoilsho	4869	3	-	-	HYPH
cord-006229-7yoilsho	4869	4	ß	ß	NN
cord-006229-7yoilsho	4869	5	-	-	HYPH
cord-006229-7yoilsho	4869	6	cyclodextrin	cyclodextrin	NN
cord-006229-7yoilsho	4869	7	as	as	IN
cord-006229-7yoilsho	4869	8	a	a	DT
cord-006229-7yoilsho	4869	9	solubilizer	solubilizer	NN
cord-006229-7yoilsho	4869	10	,	,	,
cord-006229-7yoilsho	4869	11	opening	open	VBG
cord-006229-7yoilsho	4869	12	activityof	activityof	NNP
cord-006229-7yoilsho	4869	13	BO1	BO1	NNP
cord-006229-7yoilsho	4869	14	became	become	VBD
cord-006229-7yoilsho	4869	15	detectable	detectable	JJ
cord-006229-7yoilsho	4869	16	in	in	IN
cord-006229-7yoilsho	4869	17	mice	mouse	NNS
cord-006229-7yoilsho	4869	18	.	.	.
cord-006229-7yoilsho	4870	1	Due	due	IN
cord-006229-7yoilsho	4870	2	to	to	IN
cord-006229-7yoilsho	4870	3	short	short	JJ
cord-006229-7yoilsho	4870	4	stability	stability	NN
cord-006229-7yoilsho	4870	5	(	(	-LRB-
cord-006229-7yoilsho	4870	6	<	<	NNP
cord-006229-7yoilsho	4870	7	2	2	CD
cord-006229-7yoilsho	4870	8	h	h	NNP
cord-006229-7yoilsho	4870	9	)	)	-RRB-
cord-006229-7yoilsho	4870	10	of	of	IN
cord-006229-7yoilsho	4870	11	BO1	BO1	NNP
cord-006229-7yoilsho	4870	12	in	in	IN
cord-006229-7yoilsho	4870	13	the	the	DT
cord-006229-7yoilsho	4870	14	bloodplasma	bloodplasma	NNP
cord-006229-7yoilsho	4870	15	repeated	repeat	VBD
cord-006229-7yoilsho	4870	16	administration	administration	NN
cord-006229-7yoilsho	4870	17	(	(	-LRB-
cord-006229-7yoilsho	4870	18	1.5	1.5	CD
cord-006229-7yoilsho	4870	19	mg	mg	NNP
cord-006229-7yoilsho	4870	20	/	/	SYM
cord-006229-7yoilsho	4870	21	kg	kg	NNP
cord-006229-7yoilsho	4870	22	i.v	i.v	NNP
cord-006229-7yoilsho	4870	23	.	.	NNP
cord-006229-7yoilsho	4870	24	)	)	-RRB-
cord-006229-7yoilsho	4870	25	was	be	VBD
cord-006229-7yoilsho	4870	26	required	require	VBN
cord-006229-7yoilsho	4870	27	to	to	TO
cord-006229-7yoilsho	4870	28	induce	induce	VB
cord-006229-7yoilsho	4870	29	significantly	significantly	RB
cord-006229-7yoilsho	4870	30	increased	increase	VBN
cord-006229-7yoilsho	4870	31	permeability	permeability	NN
cord-006229-7yoilsho	4870	32	of	of	IN
cord-006229-7yoilsho	4870	33	the	the	DT
cord-006229-7yoilsho	4870	34	BBB	BBB	NNP
cord-006229-7yoilsho	4870	35	for	for	IN
cord-006229-7yoilsho	4870	36	Na	Na	NNP
cord-006229-7yoilsho	4870	37	-	-	HYPH
cord-006229-7yoilsho	4870	38	fluorescein(mw	fluorescein(mw	NNS
cord-006229-7yoilsho	4870	39	376	376	CD
cord-006229-7yoilsho	4870	40	Da	Da	NNS
cord-006229-7yoilsho	4870	41	)	)	-RRB-
cord-006229-7yoilsho	4870	42	.	.	.
cord-006229-7yoilsho	4871	1	The	the	DT
cord-006229-7yoilsho	4871	2	small	small	JJ
cord-006229-7yoilsho	4871	3	molecule	molecule	NN
cord-006229-7yoilsho	4871	4	BO1	BO1	NNP
cord-006229-7yoilsho	4871	5	is	be	VBZ
cord-006229-7yoilsho	4871	6	a	a	DT
cord-006229-7yoilsho	4871	7	promising	promising	JJ
cord-006229-7yoilsho	4871	8	new	new	JJ
cord-006229-7yoilsho	4871	9	approach	approach	NN
cord-006229-7yoilsho	4871	10	for	for	IN
cord-006229-7yoilsho	4871	11	transient	transient	JJ
cord-006229-7yoilsho	4871	12	opening	opening	NN
cord-006229-7yoilsho	4871	13	of	of	IN
cord-006229-7yoilsho	4871	14	the	the	DT
cord-006229-7yoilsho	4871	15	BBB	BBB	NNP
cord-006229-7yoilsho	4871	16	in	in	IN
cord-006229-7yoilsho	4871	17	vivo	vivo	NN
cord-006229-7yoilsho	4871	18	.	.	.
cord-006229-7yoilsho	4872	1	Further	further	JJ
cord-006229-7yoilsho	4872	2	modification	modification	NN
cord-006229-7yoilsho	4872	3	of	of	IN
cord-006229-7yoilsho	4872	4	the	the	DT
cord-006229-7yoilsho	4872	5	stability	stability	NN
cord-006229-7yoilsho	4872	6	and	and	CC
cord-006229-7yoilsho	4872	7	solubility	solubility	NN
cord-006229-7yoilsho	4872	8	of	of	IN
cord-006229-7yoilsho	4872	9	BO1	BO1	NNP
cord-006229-7yoilsho	4872	10	is	be	VBZ
cord-006229-7yoilsho	4872	11	necessary	necessary	JJ
cord-006229-7yoilsho	4872	12	to	to	TO
cord-006229-7yoilsho	4872	13	optimize	optimize	VB
cord-006229-7yoilsho	4872	14	its	-PRON-	PRP$
cord-006229-7yoilsho	4872	15	applicability	applicability	NN
cord-006229-7yoilsho	4872	16	.	.	.
cord-006229-7yoilsho	4873	1	The	the	DT
cord-006229-7yoilsho	4873	2	complex	complex	NN
cord-006229-7yoilsho	4873	3	of	of	IN
cord-006229-7yoilsho	4873	4	tight	tight	JJ
cord-006229-7yoilsho	4873	5	junction	junction	NN
cord-006229-7yoilsho	4873	6	(	(	-LRB-
cord-006229-7yoilsho	4873	7	TJ	TJ	NNP
cord-006229-7yoilsho	4873	8	)	)	-RRB-
cord-006229-7yoilsho	4873	9	proteins	protein	NNS
cord-006229-7yoilsho	4873	10	is	be	VBZ
cord-006229-7yoilsho	4873	11	located	locate	VBN
cord-006229-7yoilsho	4873	12	between	between	IN
cord-006229-7yoilsho	4873	13	opposing	oppose	VBG
cord-006229-7yoilsho	4873	14	epithelial	epithelial	JJ
cord-006229-7yoilsho	4873	15	or	or	CC
cord-006229-7yoilsho	4873	16	endothelial	endothelial	JJ
cord-006229-7yoilsho	4873	17	cells	cell	NNS
cord-006229-7yoilsho	4873	18	.	.	.
cord-006229-7yoilsho	4874	1	TJs	tj	NNS
cord-006229-7yoilsho	4874	2	restrict	restrict	VBP
cord-006229-7yoilsho	4874	3	the	the	DT
cord-006229-7yoilsho	4874	4	paracellular	paracellular	JJ
cord-006229-7yoilsho	4874	5	permeation	permeation	NN
cord-006229-7yoilsho	4874	6	of	of	IN
cord-006229-7yoilsho	4874	7	ions	ion	NNS
cord-006229-7yoilsho	4874	8	and	and	CC
cord-006229-7yoilsho	4874	9	other	other	JJ
cord-006229-7yoilsho	4874	10	solutes	solute	NNS
cord-006229-7yoilsho	4874	11	.	.	.
cord-006229-7yoilsho	4875	1	Tricellulin	Tricellulin	NNP
cord-006229-7yoilsho	4875	2	(	(	-LRB-
cord-006229-7yoilsho	4875	3	Tric	Tric	NNP
cord-006229-7yoilsho	4875	4	)	)	-RRB-
cord-006229-7yoilsho	4875	5	tightens	tighten	VBZ
cord-006229-7yoilsho	4875	6	tricellular	tricellular	NNP
cord-006229-7yoilsho	4875	7	TJs	TJs	NNP
cord-006229-7yoilsho	4875	8	(	(	-LRB-
cord-006229-7yoilsho	4875	9	tTJs	ttjs	NN
cord-006229-7yoilsho	4875	10	)	)	-RRB-
cord-006229-7yoilsho	4875	11	and	and	CC
cord-006229-7yoilsho	4875	12	regulates	regulate	VBZ
cord-006229-7yoilsho	4875	13	bicellular	bicellular	JJ
cord-006229-7yoilsho	4875	14	TJ	TJ	NNP
cord-006229-7yoilsho	4875	15	(	(	-LRB-
cord-006229-7yoilsho	4875	16	bTJ	bTJ	NNP
cord-006229-7yoilsho	4875	17	)	)	-RRB-
cord-006229-7yoilsho	4875	18	proteins	protein	NNS
cord-006229-7yoilsho	4875	19	like	like	IN
cord-006229-7yoilsho	4875	20	claudins	claudin	NNS
cord-006229-7yoilsho	4875	21	and	and	CC
cord-006229-7yoilsho	4875	22	occludin	occludin	NNP
cord-006229-7yoilsho	4875	23	(	(	-LRB-
cord-006229-7yoilsho	4875	24	Occl	Occl	NNP
cord-006229-7yoilsho	4875	25	)	)	-RRB-
cord-006229-7yoilsho	4875	26	.	.	.
cord-006229-7yoilsho	4876	1	Current	current	JJ
cord-006229-7yoilsho	4876	2	data	datum	NNS
cord-006229-7yoilsho	4876	3	suggest	suggest	VBP
cord-006229-7yoilsho	4876	4	an	an	DT
cord-006229-7yoilsho	4876	5	important	important	JJ
cord-006229-7yoilsho	4876	6	role	role	NN
cord-006229-7yoilsho	4876	7	of	of	IN
cord-006229-7yoilsho	4876	8	tTJs	ttjs	CD
cord-006229-7yoilsho	4877	1	at	at	IN
cord-006229-7yoilsho	4877	2	the	the	DT
cord-006229-7yoilsho	4877	3	blood	blood	NN
cord-006229-7yoilsho	4877	4	-	-	HYPH
cord-006229-7yoilsho	4877	5	brain	brain	NN
cord-006229-7yoilsho	4877	6	barrier	barrier	NN
cord-006229-7yoilsho	4877	7	(	(	-LRB-
cord-006229-7yoilsho	4877	8	BBB	BBB	NNP
cord-006229-7yoilsho	4877	9	)	)	-RRB-
cord-006229-7yoilsho	4877	10	.	.	.
cord-006229-7yoilsho	4878	1	A	a	DT
cord-006229-7yoilsho	4878	2	main	main	JJ
cord-006229-7yoilsho	4878	3	pharmacological	pharmacological	JJ
cord-006229-7yoilsho	4878	4	problem	problem	NN
cord-006229-7yoilsho	4878	5	is	be	VBZ
cord-006229-7yoilsho	4878	6	modulation	modulation	NN
cord-006229-7yoilsho	4878	7	of	of	IN
cord-006229-7yoilsho	4878	8	the	the	DT
cord-006229-7yoilsho	4878	9	BBB	BBB	NNP
cord-006229-7yoilsho	4878	10	to	to	TO
cord-006229-7yoilsho	4878	11	improve	improve	VB
cord-006229-7yoilsho	4878	12	drug	drug	NN
cord-006229-7yoilsho	4878	13	delivery	delivery	NN
cord-006229-7yoilsho	4878	14	to	to	IN
cord-006229-7yoilsho	4878	15	the	the	DT
cord-006229-7yoilsho	4878	16	CNS	CNS	NNP
cord-006229-7yoilsho	4878	17	.	.	.
cord-006229-7yoilsho	4879	1	Therefore	therefore	RB
cord-006229-7yoilsho	4879	2	,	,	,
cord-006229-7yoilsho	4879	3	TricSI	TricSI	NNP
cord-006229-7yoilsho	4879	4	has	have	VBZ
cord-006229-7yoilsho	4879	5	been	be	VBN
cord-006229-7yoilsho	4879	6	developed	develop	VBN
cord-006229-7yoilsho	4879	7	as	as	IN
cord-006229-7yoilsho	4879	8	a	a	DT
cord-006229-7yoilsho	4879	9	peptide	peptide	NN
cord-006229-7yoilsho	4879	10	taken	take	VBN
cord-006229-7yoilsho	4879	11	from	from	IN
cord-006229-7yoilsho	4879	12	Tric	Tric	NNP
cord-006229-7yoilsho	4879	13	to	to	TO
cord-006229-7yoilsho	4879	14	open	open	VB
cord-006229-7yoilsho	4879	15	tissue	tissue	NN
cord-006229-7yoilsho	4879	16	barriers	barrier	NNS
cord-006229-7yoilsho	4879	17	specifically	specifically	RB
cord-006229-7yoilsho	4879	18	and	and	CC
cord-006229-7yoilsho	4879	19	transiently	transiently	RB
cord-006229-7yoilsho	4879	20	.	.	.
cord-006229-7yoilsho	4880	1	Initially	initially	RB
cord-006229-7yoilsho	4880	2	,	,	,
cord-006229-7yoilsho	4880	3	a	a	DT
cord-006229-7yoilsho	4880	4	recombinant	recombinant	JJ
cord-006229-7yoilsho	4880	5	protein	protein	NN
cord-006229-7yoilsho	4880	6	was	be	VBD
cord-006229-7yoilsho	4880	7	generated	generate	VBN
cord-006229-7yoilsho	4880	8	based	base	VBN
cord-006229-7yoilsho	4880	9	on	on	IN
cord-006229-7yoilsho	4880	10	a	a	DT
cord-006229-7yoilsho	4880	11	sequence	sequence	NN
cord-006229-7yoilsho	4880	12	of	of	IN
cord-006229-7yoilsho	4880	13	an	an	DT
cord-006229-7yoilsho	4880	14	extracellular	extracellular	JJ
cord-006229-7yoilsho	4880	15	loop	loop	NN
cord-006229-7yoilsho	4880	16	of	of	IN
cord-006229-7yoilsho	4880	17	Tric	Tric	NNP
cord-006229-7yoilsho	4880	18	,	,	,
cord-006229-7yoilsho	4880	19	tagged	tag	VBN
cord-006229-7yoilsho	4880	20	with	with	IN
cord-006229-7yoilsho	4880	21	maltose	maltose	NN
cord-006229-7yoilsho	4880	22	binding	bind	VBG
cord-006229-7yoilsho	4880	23	protein	protein	NN
cord-006229-7yoilsho	4880	24	.	.	.
cord-006229-7yoilsho	4881	1	The	the	DT
cord-006229-7yoilsho	4881	2	fusion	fusion	NN
cord-006229-7yoilsho	4881	3	protein	protein	NN
cord-006229-7yoilsho	4881	4	caused	cause	VBD
cord-006229-7yoilsho	4881	5	down	down	NN
cord-006229-7yoilsho	4881	6	-	-	HYPH
cord-006229-7yoilsho	4881	7	regulation	regulation	NN
cord-006229-7yoilsho	4881	8	of	of	IN
cord-006229-7yoilsho	4881	9	Tric	Tric	NNP
cord-006229-7yoilsho	4881	10	,	,	,
cord-006229-7yoilsho	4881	11	internalization	internalization	NN
cord-006229-7yoilsho	4881	12	of	of	IN
cord-006229-7yoilsho	4881	13	both	both	CC
cord-006229-7yoilsho	4881	14	Tric	Tric	NNP
cord-006229-7yoilsho	4881	15	and	and	CC
cord-006229-7yoilsho	4881	16	Occl	Occl	NNP
cord-006229-7yoilsho	4881	17	(	(	-LRB-
cord-006229-7yoilsho	4881	18	confocal	confocal	JJ
cord-006229-7yoilsho	4881	19	laser	laser	NN
cord-006229-7yoilsho	4881	20	scanning	scanning	NN
cord-006229-7yoilsho	4881	21	microscopy	microscopy	NNS
cord-006229-7yoilsho	4881	22	)	)	-RRB-
cord-006229-7yoilsho	4881	23	,	,	,
cord-006229-7yoilsho	4881	24	and	and	CC
cord-006229-7yoilsho	4881	25	a	a	DT
cord-006229-7yoilsho	4881	26	significant	significant	JJ
cord-006229-7yoilsho	4881	27	decrease	decrease	NN
cord-006229-7yoilsho	4881	28	in	in	IN
cord-006229-7yoilsho	4881	29	transcellular	transcellular	JJ
cord-006229-7yoilsho	4881	30	electrical	electrical	JJ
cord-006229-7yoilsho	4881	31	resistance	resistance	NN
cord-006229-7yoilsho	4881	32	(	(	-LRB-
cord-006229-7yoilsho	4881	33	TER	TER	NNP
cord-006229-7yoilsho	4881	34	)	)	-RRB-
cord-006229-7yoilsho	4881	35	of	of	IN
cord-006229-7yoilsho	4881	36	a	a	DT
cord-006229-7yoilsho	4881	37	human	human	JJ
cord-006229-7yoilsho	4881	38	epithelial	epithelial	JJ
cord-006229-7yoilsho	4881	39	colorectal	colorectal	JJ
cord-006229-7yoilsho	4881	40	adenocarcinoma	adenocarcinoma	NN
cord-006229-7yoilsho	4881	41	cell	cell	NN
cord-006229-7yoilsho	4881	42	line	line	NN
cord-006229-7yoilsho	4881	43	.	.	.
cord-006229-7yoilsho	4882	1	Then	then	RB
cord-006229-7yoilsho	4882	2	,	,	,
cord-006229-7yoilsho	4882	3	studies	study	NNS
cord-006229-7yoilsho	4882	4	with	with	IN
cord-006229-7yoilsho	4882	5	the	the	DT
cord-006229-7yoilsho	4882	6	synthetic	synthetic	JJ
cord-006229-7yoilsho	4882	7	peptide	peptide	NN
cord-006229-7yoilsho	4882	8	TricSI	TricSI	NNP
cord-006229-7yoilsho	4882	9	indicated	indicate	VBD
cord-006229-7yoilsho	4882	10	its	-PRON-	PRP$
cord-006229-7yoilsho	4882	11	capacity	capacity	NN
cord-006229-7yoilsho	4882	12	of	of	IN
cord-006229-7yoilsho	4882	13	cell	cell	NN
cord-006229-7yoilsho	4882	14	barrier	barrier	NN
cord-006229-7yoilsho	4882	15	openingafter	openingafter	NNP
cord-006229-7yoilsho	4882	16	about	about	RB
cord-006229-7yoilsho	4882	17	16	16	CD
cord-006229-7yoilsho	4882	18	h	h	NN
cord-006229-7yoilsho	4882	19	of	of	IN
cord-006229-7yoilsho	4882	20	incubation	incubation	NN
cord-006229-7yoilsho	4882	21	with	with	IN
cord-006229-7yoilsho	4882	22	concentrations	concentration	NNS
cord-006229-7yoilsho	4882	23	varying	vary	VBG
cord-006229-7yoilsho	4882	24	from	from	IN
cord-006229-7yoilsho	4882	25	100	100	CD
cord-006229-7yoilsho	4882	26	to	to	TO
cord-006229-7yoilsho	4882	27	150	150	CD
cord-006229-7yoilsho	4882	28	µMaffecting	µmaffecte	VBG
cord-006229-7yoilsho	4882	29	the	the	DT
cord-006229-7yoilsho	4882	30	membrane	membrane	NN
cord-006229-7yoilsho	4882	31	localization	localization	NN
cord-006229-7yoilsho	4882	32	of	of	IN
cord-006229-7yoilsho	4882	33	Tricand	Tricand	NNP
cord-006229-7yoilsho	4882	34	Occl	Occl	NNP
cord-006229-7yoilsho	4882	35	.	.	.
cord-006229-7yoilsho	4883	1	Barrier	barrier	NN
cord-006229-7yoilsho	4883	2	opening	opening	NN
cord-006229-7yoilsho	4883	3	was	be	VBD
cord-006229-7yoilsho	4883	4	proven	prove	VBN
cord-006229-7yoilsho	4883	5	by	by	IN
cord-006229-7yoilsho	4883	6	decreasing	decrease	VBG
cord-006229-7yoilsho	4883	7	TER	TER	NNP
cord-006229-7yoilsho	4883	8	,	,	,
cord-006229-7yoilsho	4883	9	increasing	increase	VBG
cord-006229-7yoilsho	4883	10	permeability	permeability	NN
cord-006229-7yoilsho	4883	11	coefficient	coefficient	NN
cord-006229-7yoilsho	4883	12	of	of	IN
cord-006229-7yoilsho	4883	13	lucifer	lucifer	NNP
cord-006229-7yoilsho	4883	14	yellow	yellow	NNP
cord-006229-7yoilsho	4883	15	(	(	-LRB-
cord-006229-7yoilsho	4883	16	457	457	CD
cord-006229-7yoilsho	4883	17	Da	Da	NNP
cord-006229-7yoilsho	4883	18	)	)	-RRB-
cord-006229-7yoilsho	4883	19	and	and	CC
cord-006229-7yoilsho	4883	20	FITC	FITC	NNP
cord-006229-7yoilsho	4883	21	-	-	HYPH
cord-006229-7yoilsho	4883	22	dextran	dextran	NN
cord-006229-7yoilsho	4883	23	(	(	-LRB-
cord-006229-7yoilsho	4883	24	10	10	CD
cord-006229-7yoilsho	4883	25	kDa	kDa	NNS
cord-006229-7yoilsho	4883	26	)	)	-RRB-
cord-006229-7yoilsho	4883	27	;	;	:
cord-006229-7yoilsho	4883	28	the	the	DT
cord-006229-7yoilsho	4883	29	localization	localization	NN
cord-006229-7yoilsho	4883	30	of	of	IN
cord-006229-7yoilsho	4883	31	Tric	Tric	NNP
cord-006229-7yoilsho	4883	32	elongated	elongated	JJ
cord-006229-7yoilsho	4883	33	from	from	IN
cord-006229-7yoilsho	4883	34	tTJs	ttjs	XX
cord-006229-7yoilsho	4884	1	towards	towards	IN
cord-006229-7yoilsho	4884	2	bTJs	bTJs	NNP
cord-006229-7yoilsho	4885	1	and	and	CC
cord-006229-7yoilsho	4885	2	Cldn1	Cldn1	NNP
cord-006229-7yoilsho	4885	3	was	be	VBD
cord-006229-7yoilsho	4885	4	weakened	weaken	VBN
cord-006229-7yoilsho	4885	5	at	at	IN
cord-006229-7yoilsho	4885	6	bTJs	bTJs	NNP
cord-006229-7yoilsho	4885	7	.	.	.
cord-006229-7yoilsho	4886	1	Physiochemical	physiochemical	JJ
cord-006229-7yoilsho	4886	2	properties	property	NNS
cord-006229-7yoilsho	4886	3	of	of	IN
cord-006229-7yoilsho	4886	4	TricSIexamined	TricSIexamined	NNP
cord-006229-7yoilsho	4886	5	by	by	IN
cord-006229-7yoilsho	4886	6	circular	circular	JJ
cord-006229-7yoilsho	4886	7	dichroism	dichroism	NN
cord-006229-7yoilsho	4886	8	spectroscopy	spectroscopy	NN
cord-006229-7yoilsho	4886	9	suggested	suggest	VBD
cord-006229-7yoilsho	4886	10	ß	ß	NN
cord-006229-7yoilsho	4886	11	-	-	HYPH
cord-006229-7yoilsho	4886	12	strand	strand	NN
cord-006229-7yoilsho	4886	13	structure	structure	NN
cord-006229-7yoilsho	4886	14	and	and	CC
cord-006229-7yoilsho	4886	15	no	no	DT
cord-006229-7yoilsho	4886	16	helical	helical	JJ
cord-006229-7yoilsho	4886	17	propensity	propensity	NN
cord-006229-7yoilsho	4886	18	.	.	.
cord-006229-7yoilsho	4887	1	Taken	take	VBN
cord-006229-7yoilsho	4887	2	together	together	RB
cord-006229-7yoilsho	4887	3	,	,	,
cord-006229-7yoilsho	4887	4	a	a	DT
cord-006229-7yoilsho	4887	5	Tric	Tric	NNP
cord-006229-7yoilsho	4887	6	-	-	HYPH
cord-006229-7yoilsho	4887	7	derived	derive	VBN
cord-006229-7yoilsho	4887	8	peptide	peptide	NN
cord-006229-7yoilsho	4887	9	has	have	VBZ
cord-006229-7yoilsho	4887	10	been	be	VBN
cord-006229-7yoilsho	4887	11	identified	identify	VBN
cord-006229-7yoilsho	4887	12	increasing	increase	VBG
cord-006229-7yoilsho	4887	13	the	the	DT
cord-006229-7yoilsho	4887	14	paracellular	paracellular	JJ
cord-006229-7yoilsho	4887	15	permeability	permeability	NN
cord-006229-7yoilsho	4887	16	of	of	IN
cord-006229-7yoilsho	4887	17	tissue	tissue	NN
cord-006229-7yoilsho	4887	18	barriers	barrier	NNS
cord-006229-7yoilsho	4887	19	and	and	CC
cord-006229-7yoilsho	4887	20	redistributing	redistribute	VBG
cord-006229-7yoilsho	4887	21	the	the	DT
cord-006229-7yoilsho	4887	22	cellular	cellular	JJ
cord-006229-7yoilsho	4887	23	localization	localization	NN
cord-006229-7yoilsho	4887	24	of	of	IN
cord-006229-7yoilsho	4887	25	TJ	TJ	NNP
cord-006229-7yoilsho	4887	26	proteins	protein	NNS
cord-006229-7yoilsho	4887	27	.	.	.
cord-006229-7yoilsho	4888	1	TricSI	TricSI	NNP
cord-006229-7yoilsho	4888	2	is	be	VBZ
cord-006229-7yoilsho	4888	3	a	a	DT
cord-006229-7yoilsho	4888	4	novel	novel	NN
cord-006229-7yoilsho	4888	5	,	,	,
cord-006229-7yoilsho	4888	6	promising	promising	JJ
cord-006229-7yoilsho	4888	7	tool	tool	NN
cord-006229-7yoilsho	4888	8	to	to	TO
cord-006229-7yoilsho	4888	9	overcome	overcome	VB
cord-006229-7yoilsho	4888	10	cerebral	cerebral	JJ
cord-006229-7yoilsho	4888	11	barriers	barrier	NNS
cord-006229-7yoilsho	4888	12	with	with	IN
cord-006229-7yoilsho	4888	13	the	the	DT
cord-006229-7yoilsho	4888	14	potential	potential	NN
cord-006229-7yoilsho	4888	15	to	to	TO
cord-006229-7yoilsho	4888	16	improve	improve	VB
cord-006229-7yoilsho	4888	17	drug	drug	NN
cord-006229-7yoilsho	4888	18	delivery	delivery	NN
cord-006229-7yoilsho	4888	19	to	to	IN
cord-006229-7yoilsho	4888	20	the	the	DT
cord-006229-7yoilsho	4888	21	CNS	CNS	NNP
cord-006229-7yoilsho	4888	22	.	.	.
cord-006229-7yoilsho	4889	1	Further	further	JJ
cord-006229-7yoilsho	4889	2	experiments	experiment	NNS
cord-006229-7yoilsho	4889	3	are	be	VBP
cord-006229-7yoilsho	4889	4	needed	need	VBN
cord-006229-7yoilsho	4889	5	to	to	TO
cord-006229-7yoilsho	4889	6	better	better	RB
cord-006229-7yoilsho	4889	7	understand	understand	VB
cord-006229-7yoilsho	4889	8	the	the	DT
cord-006229-7yoilsho	4889	9	role	role	NN
cord-006229-7yoilsho	4889	10	of	of	IN
cord-006229-7yoilsho	4889	11	Tric	Tric	NNP
cord-006229-7yoilsho	4889	12	in	in	IN
cord-006229-7yoilsho	4889	13	tissue	tissue	NN
cord-006229-7yoilsho	4889	14	barriers	barrier	NNS
cord-006229-7yoilsho	4889	15	as	as	RB
cord-006229-7yoilsho	4889	16	well	well	RB
cord-006229-7yoilsho	4889	17	as	as	IN
cord-006229-7yoilsho	4889	18	to	to	TO
cord-006229-7yoilsho	4889	19	clarify	clarify	VB
cord-006229-7yoilsho	4889	20	the	the	DT
cord-006229-7yoilsho	4889	21	mode	mode	NN
cord-006229-7yoilsho	4889	22	of	of	IN
cord-006229-7yoilsho	4889	23	action	action	NN
cord-006229-7yoilsho	4889	24	of	of	IN
cord-006229-7yoilsho	4889	25	TricSI	TricSI	NNP
cord-006229-7yoilsho	4889	26	.	.	.
cord-006229-7yoilsho	4890	1	Introduction	introduction	NN
cord-006229-7yoilsho	4890	2	:	:	:
cord-006229-7yoilsho	4891	1	Lung	lung	NN
cord-006229-7yoilsho	4891	2	transplantation	transplantation	NN
cord-006229-7yoilsho	4891	3	has	have	VBZ
cord-006229-7yoilsho	4891	4	become	become	VBN
cord-006229-7yoilsho	4891	5	an	an	DT
cord-006229-7yoilsho	4891	6	established	establish	VBN
cord-006229-7yoilsho	4891	7	treatment	treatment	NN
cord-006229-7yoilsho	4891	8	option	option	NN
cord-006229-7yoilsho	4891	9	for	for	IN
cord-006229-7yoilsho	4891	10	a	a	DT
cord-006229-7yoilsho	4891	11	variety	variety	NN
cord-006229-7yoilsho	4891	12	of	of	IN
cord-006229-7yoilsho	4891	13	end	end	NN
cord-006229-7yoilsho	4891	14	-	-	HYPH
cord-006229-7yoilsho	4891	15	stage	stage	NN
cord-006229-7yoilsho	4891	16	lung	lung	NN
cord-006229-7yoilsho	4891	17	diseases	disease	NNS
cord-006229-7yoilsho	4891	18	,	,	,
cord-006229-7yoilsho	4891	19	but	but	CC
cord-006229-7yoilsho	4891	20	the	the	DT
cord-006229-7yoilsho	4891	21	long	long	JJ
cord-006229-7yoilsho	4891	22	-	-	HYPH
cord-006229-7yoilsho	4891	23	term	term	NN
cord-006229-7yoilsho	4891	24	survival	survival	NN
cord-006229-7yoilsho	4891	25	is	be	VBZ
cord-006229-7yoilsho	4891	26	often	often	RB
cord-006229-7yoilsho	4891	27	disappointing	disappointing	JJ
cord-006229-7yoilsho	4891	28	.	.	.
cord-006229-7yoilsho	4892	1	The	the	DT
cord-006229-7yoilsho	4892	2	leading	leading	JJ
cord-006229-7yoilsho	4892	3	cause	cause	NN
cord-006229-7yoilsho	4892	4	of	of	IN
cord-006229-7yoilsho	4892	5	death	death	NN
cord-006229-7yoilsho	4892	6	is	be	VBZ
cord-006229-7yoilsho	4892	7	generally	generally	RB
cord-006229-7yoilsho	4892	8	chronic	chronic	JJ
cord-006229-7yoilsho	4892	9	rejection	rejection	NN
cord-006229-7yoilsho	4892	10	which	which	WDT
cord-006229-7yoilsho	4892	11	is	be	VBZ
cord-006229-7yoilsho	4892	12	characterized	characterize	VBN
cord-006229-7yoilsho	4892	13	by	by	IN
cord-006229-7yoilsho	4892	14	inflammation	inflammation	NN
cord-006229-7yoilsho	4892	15	and	and	CC
cord-006229-7yoilsho	4892	16	fibrous	fibrous	JJ
cord-006229-7yoilsho	4892	17	obliteration	obliteration	NN
cord-006229-7yoilsho	4892	18	of	of	IN
cord-006229-7yoilsho	4892	19	the	the	DT
cord-006229-7yoilsho	4892	20	small	small	JJ
cord-006229-7yoilsho	4892	21	airways	airway	NNS
cord-006229-7yoilsho	4892	22	,	,	,
cord-006229-7yoilsho	4892	23	progressively	progressively	RB
cord-006229-7yoilsho	4892	24	leading	lead	VBG
cord-006229-7yoilsho	4892	25	to	to	IN
cord-006229-7yoilsho	4892	26	a	a	DT
cord-006229-7yoilsho	4892	27	reduction	reduction	NN
cord-006229-7yoilsho	4892	28	of	of	IN
cord-006229-7yoilsho	4892	29	the	the	DT
cord-006229-7yoilsho	4892	30	airflow	airflow	NN
cord-006229-7yoilsho	4892	31	.	.	.
cord-006229-7yoilsho	4893	1	The	the	DT
cord-006229-7yoilsho	4893	2	mouse	mouse	NN
cord-006229-7yoilsho	4893	3	heterotopic	heterotopic	NNP
cord-006229-7yoilsho	4893	4	tracheal	tracheal	NN
cord-006229-7yoilsho	4893	5	transplantation	transplantation	NN
cord-006229-7yoilsho	4893	6	model	model	NN
cord-006229-7yoilsho	4893	7	is	be	VBZ
cord-006229-7yoilsho	4893	8	widely	widely	RB
cord-006229-7yoilsho	4893	9	used	use	VBN
cord-006229-7yoilsho	4893	10	as	as	IN
cord-006229-7yoilsho	4893	11	an	an	DT
cord-006229-7yoilsho	4893	12	experimental	experimental	JJ
cord-006229-7yoilsho	4893	13	model	model	NN
cord-006229-7yoilsho	4893	14	to	to	TO
cord-006229-7yoilsho	4893	15	study	study	VB
cord-006229-7yoilsho	4893	16	the	the	DT
cord-006229-7yoilsho	4893	17	development	development	NN
cord-006229-7yoilsho	4893	18	of	of	IN
cord-006229-7yoilsho	4893	19	obliterative	obliterative	JJ
cord-006229-7yoilsho	4893	20	airway	airway	NN
cord-006229-7yoilsho	4893	21	disease	disease	NN
cord-006229-7yoilsho	4893	22	.	.	.
cord-006229-7yoilsho	4894	1	Despite	despite	IN
cord-006229-7yoilsho	4894	2	its	-PRON-	PRP$
cord-006229-7yoilsho	4894	3	widespread	widespread	JJ
cord-006229-7yoilsho	4894	4	application	application	NN
cord-006229-7yoilsho	4894	5	,	,	,
cord-006229-7yoilsho	4894	6	the	the	DT
cord-006229-7yoilsho	4894	7	heterotopic	heterotopic	NNP
cord-006229-7yoilsho	4894	8	transplantation	transplantation	NN
cord-006229-7yoilsho	4894	9	model	model	NN
cord-006229-7yoilsho	4894	10	does	do	VBZ
cord-006229-7yoilsho	4894	11	have	have	VB
cord-006229-7yoilsho	4894	12	a	a	DT
cord-006229-7yoilsho	4894	13	number	number	NN
cord-006229-7yoilsho	4894	14	of	of	IN
cord-006229-7yoilsho	4894	15	limitations	limitation	NNS
cord-006229-7yoilsho	4894	16	,	,	,
cord-006229-7yoilsho	4894	17	as	as	IN
cord-006229-7yoilsho	4894	18	for	for	IN
cord-006229-7yoilsho	4894	19	example	example	NN
cord-006229-7yoilsho	4894	20	the	the	DT
cord-006229-7yoilsho	4894	21	lack	lack	NN
cord-006229-7yoilsho	4894	22	of	of	IN
cord-006229-7yoilsho	4894	23	airflow	airflow	NN
cord-006229-7yoilsho	4894	24	.	.	.
cord-006229-7yoilsho	4895	1	The	the	DT
cord-006229-7yoilsho	4895	2	present	present	JJ
cord-006229-7yoilsho	4895	3	study	study	NN
cord-006229-7yoilsho	4895	4	provides	provide	VBZ
cord-006229-7yoilsho	4895	5	a	a	DT
cord-006229-7yoilsho	4895	6	description	description	NN
cord-006229-7yoilsho	4895	7	of	of	IN
cord-006229-7yoilsho	4895	8	the	the	DT
cord-006229-7yoilsho	4895	9	orthotopic	orthotopic	JJ
cord-006229-7yoilsho	4895	10	tracheal	tracheal	NNP
cord-006229-7yoilsho	4895	11	transplantation	transplantation	NN
cord-006229-7yoilsho	4895	12	mouse	mouse	NN
cord-006229-7yoilsho	4895	13	model	model	NN
cord-006229-7yoilsho	4895	14	,	,	,
cord-006229-7yoilsho	4895	15	which	which	WDT
cord-006229-7yoilsho	4895	16	shares	share	VBZ
cord-006229-7yoilsho	4895	17	more	more	JJR
cord-006229-7yoilsho	4895	18	similarities	similarity	NNS
cord-006229-7yoilsho	4895	19	with	with	IN
cord-006229-7yoilsho	4895	20	transplant	transplant	NN
cord-006229-7yoilsho	4895	21	situation	situation	NN
cord-006229-7yoilsho	4895	22	in	in	IN
cord-006229-7yoilsho	4895	23	humans	human	NNS
cord-006229-7yoilsho	4895	24	,	,	,
cord-006229-7yoilsho	4895	25	and	and	CC
cord-006229-7yoilsho	4895	26	provides	provide	VBZ
cord-006229-7yoilsho	4895	27	the	the	DT
cord-006229-7yoilsho	4895	28	analysis	analysis	NN
cord-006229-7yoilsho	4895	29	of	of	IN
cord-006229-7yoilsho	4895	30	airway	airway	NN
cord-006229-7yoilsho	4895	31	obliteration	obliteration	NN
cord-006229-7yoilsho	4895	32	via	via	IN
cord-006229-7yoilsho	4895	33	micro	micro	NNP
cord-006229-7yoilsho	4895	34	CT	CT	NNP
cord-006229-7yoilsho	4895	35	and	and	CC
cord-006229-7yoilsho	4895	36	histological	histological	JJ
cord-006229-7yoilsho	4895	37	evaluation	evaluation	NN
cord-006229-7yoilsho	4895	38	.	.	.
cord-006229-7yoilsho	4896	1	Methods	method	NNS
cord-006229-7yoilsho	4896	2	:	:	:
cord-006229-7yoilsho	4896	3	A	a	DT
cord-006229-7yoilsho	4896	4	seven	seven	CD
cord-006229-7yoilsho	4896	5	-	-	HYPH
cord-006229-7yoilsho	4896	6	ring	ring	NN
cord-006229-7yoilsho	4896	7	donor	donor	NN
cord-006229-7yoilsho	4896	8	trachea	trachea	NN
cord-006229-7yoilsho	4896	9	from	from	IN
cord-006229-7yoilsho	4896	10	BALB	BALB	NNP
cord-006229-7yoilsho	4896	11	/	/	SYM
cord-006229-7yoilsho	4896	12	c	c	NN
cord-006229-7yoilsho	4896	13	mice	mouse	NNS
cord-006229-7yoilsho	4896	14	was	be	VBD
cord-006229-7yoilsho	4896	15	implanted	implant	VBN
cord-006229-7yoilsho	4896	16	into	into	IN
cord-006229-7yoilsho	4896	17	the	the	DT
cord-006229-7yoilsho	4896	18	recipient	recipient	NN
cord-006229-7yoilsho	4896	19	C57BL/6	C57BL/6	NNP
cord-006229-7yoilsho	4896	20	mice	mouse	NNS
cord-006229-7yoilsho	4896	21	.	.	.
cord-006229-7yoilsho	4897	1	C57BL/6	C57BL/6	NNP
cord-006229-7yoilsho	4898	1	mice	mouse	NNS
cord-006229-7yoilsho	4898	2	without	without	IN
cord-006229-7yoilsho	4898	3	transplantation	transplantation	NN
cord-006229-7yoilsho	4898	4	were	be	VBD
cord-006229-7yoilsho	4898	5	used	use	VBN
cord-006229-7yoilsho	4898	6	as	as	IN
cord-006229-7yoilsho	4898	7	normal	normal	JJ
cord-006229-7yoilsho	4898	8	controls	control	NNS
cord-006229-7yoilsho	4898	9	.	.	.
cord-006229-7yoilsho	4899	1	Donor	Donor	NNP
cord-006229-7yoilsho	4899	2	C57BL/6	C57BL/6	NNP
cord-006229-7yoilsho	4899	3	mice	mouse	NNS
cord-006229-7yoilsho	4899	4	to	to	TO
cord-006229-7yoilsho	4899	5	recipient	recipient	VB
cord-006229-7yoilsho	4899	6	C57BL/6	C57BL/6	NNP
cord-006229-7yoilsho	4899	7	mice	mouse	NNS
cord-006229-7yoilsho	4899	8	were	be	VBD
cord-006229-7yoilsho	4899	9	served	serve	VBN
cord-006229-7yoilsho	4899	10	as	as	IN
cord-006229-7yoilsho	4899	11	the	the	DT
cord-006229-7yoilsho	4899	12	isograft	isograft	NNP
cord-006229-7yoilsho	4899	13	group	group	NNP
cord-006229-7yoilsho	4899	14	.	.	.
cord-006229-7yoilsho	4900	1	42	42	CD
cord-006229-7yoilsho	4900	2	days	day	NNS
cord-006229-7yoilsho	4900	3	after	after	IN
cord-006229-7yoilsho	4900	4	transplantation	transplantation	NN
cord-006229-7yoilsho	4900	5	,	,	,
cord-006229-7yoilsho	4900	6	mice	mouse	NNS
cord-006229-7yoilsho	4900	7	were	be	VBD
cord-006229-7yoilsho	4900	8	scanned	scan	VBN
cord-006229-7yoilsho	4900	9	using	use	VBG
cord-006229-7yoilsho	4900	10	an	an	DT
cord-006229-7yoilsho	4900	11	in	in	IN
cord-006229-7yoilsho	4900	12	vivo	vivo	NN
cord-006229-7yoilsho	4900	13	small	small	JJ
cord-006229-7yoilsho	4900	14	animal	animal	NN
cord-006229-7yoilsho	4900	15	µCT	µct	NN
cord-006229-7yoilsho	4900	16	(	(	-LRB-
cord-006229-7yoilsho	4900	17	SkyScan	SkyScan	NNP
cord-006229-7yoilsho	4900	18	1176	1176	CD
cord-006229-7yoilsho	4900	19	)	)	-RRB-
cord-006229-7yoilsho	4900	20	.	.	.
cord-006229-7yoilsho	4901	1	Tracheal	tracheal	JJ
cord-006229-7yoilsho	4901	2	tissue	tissue	NN
cord-006229-7yoilsho	4901	3	was	be	VBD
cord-006229-7yoilsho	4901	4	harvested	harvest	VBN
cord-006229-7yoilsho	4901	5	and	and	CC
cord-006229-7yoilsho	4901	6	fixed	fix	VBN
cord-006229-7yoilsho	4901	7	in	in	IN
cord-006229-7yoilsho	4901	8	formalin	formalin	NN
cord-006229-7yoilsho	4901	9	,	,	,
cord-006229-7yoilsho	4901	10	embedded	embed	VBN
cord-006229-7yoilsho	4901	11	in	in	IN
cord-006229-7yoilsho	4901	12	paraffin	paraffin	NN
cord-006229-7yoilsho	4901	13	,	,	,
cord-006229-7yoilsho	4901	14	cut	cut	VB
cord-006229-7yoilsho	4901	15	and	and	CC
cord-006229-7yoilsho	4901	16	stained	stain	VBN
cord-006229-7yoilsho	4901	17	with	with	IN
cord-006229-7yoilsho	4901	18	hematoxylin	hematoxylin	NNP
cord-006229-7yoilsho	4901	19	and	and	CC
cord-006229-7yoilsho	4901	20	eosin	eosin	NNP
cord-006229-7yoilsho	4901	21	(	(	-LRB-
cord-006229-7yoilsho	4901	22	H&E	H&E	NNP
cord-006229-7yoilsho	4901	23	)	)	-RRB-
cord-006229-7yoilsho	4901	24	as	as	RB
cord-006229-7yoilsho	4901	25	well	well	RB
cord-006229-7yoilsho	4901	26	as	as	IN
cord-006229-7yoilsho	4901	27	Sirius	Sirius	NNP
cord-006229-7yoilsho	4901	28	-	-	HYPH
cord-006229-7yoilsho	4901	29	red	red	JJ
cord-006229-7yoilsho	4901	30	/	/	SYM
cord-006229-7yoilsho	4901	31	Fast	Fast	NNP
cord-006229-7yoilsho	4901	32	-	-	HYPH
cord-006229-7yoilsho	4901	33	Green	Green	NNP
cord-006229-7yoilsho	4901	34	.	.	.
cord-006229-7yoilsho	4902	1	Results	result	NNS
cord-006229-7yoilsho	4902	2	and	and	CC
cord-006229-7yoilsho	4902	3	conclusions	conclusion	NNS
cord-006229-7yoilsho	4902	4	:	:	:
cord-006229-7yoilsho	4903	1	Histologic	Histologic	NNP
cord-006229-7yoilsho	4903	2	evaluation	evaluation	NN
cord-006229-7yoilsho	4903	3	showed	show	VBD
cord-006229-7yoilsho	4903	4	luminal	luminal	JJ
cord-006229-7yoilsho	4903	5	narrowing	narrowing	NN
cord-006229-7yoilsho	4903	6	with	with	IN
cord-006229-7yoilsho	4903	7	subepithelial	subepithelial	JJ
cord-006229-7yoilsho	4903	8	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	4903	9	cell	cell	NN
cord-006229-7yoilsho	4903	10	infiltrates	infiltrate	VBZ
cord-006229-7yoilsho	4903	11	and	and	CC
cord-006229-7yoilsho	4903	12	fibrosis	fibrosis	NN
cord-006229-7yoilsho	4903	13	,	,	,
cord-006229-7yoilsho	4903	14	as	as	RB
cord-006229-7yoilsho	4903	15	well	well	RB
cord-006229-7yoilsho	4903	16	as	as	IN
cord-006229-7yoilsho	4903	17	partially	partially	RB
cord-006229-7yoilsho	4903	18	damaged	damage	VBN
cord-006229-7yoilsho	4903	19	and	and	CC
cord-006229-7yoilsho	4903	20	flattened	flattened	JJ
cord-006229-7yoilsho	4903	21	epithelium	epithelium	NN
cord-006229-7yoilsho	4903	22	.	.	.
cord-006229-7yoilsho	4904	1	The	the	DT
cord-006229-7yoilsho	4904	2	aerated	aerated	JJ
cord-006229-7yoilsho	4904	3	volume	volume	NN
cord-006229-7yoilsho	4904	4	of	of	IN
cord-006229-7yoilsho	4904	5	the	the	DT
cord-006229-7yoilsho	4904	6	allogeneic	allogeneic	NN
cord-006229-7yoilsho	4904	7	grafts	graft	NNS
cord-006229-7yoilsho	4904	8	,	,	,
cord-006229-7yoilsho	4904	9	analyzed	analyze	VBN
cord-006229-7yoilsho	4904	10	by	by	IN
cord-006229-7yoilsho	4904	11	micro	micro	NNP
cord-006229-7yoilsho	4904	12	CT	CT	NNP
cord-006229-7yoilsho	4904	13	was	be	VBD
cord-006229-7yoilsho	4904	14	significantly	significantly	RB
cord-006229-7yoilsho	4904	15	reduced	reduce	VBN
cord-006229-7yoilsho	4904	16	compared	compare	VBN
cord-006229-7yoilsho	4904	17	to	to	IN
cord-006229-7yoilsho	4904	18	the	the	DT
cord-006229-7yoilsho	4904	19	isogenic	isogenic	JJ
cord-006229-7yoilsho	4904	20	control	control	NN
cord-006229-7yoilsho	4904	21	grafts	graft	NNS
cord-006229-7yoilsho	4904	22	and	and	CC
cord-006229-7yoilsho	4904	23	normal	normal	JJ
cord-006229-7yoilsho	4904	24	controls	control	NNS
cord-006229-7yoilsho	4904	25	.	.	.
cord-006229-7yoilsho	4905	1	Non	non	JJ
cord-006229-7yoilsho	4905	2	-	-	JJ
cord-006229-7yoilsho	4905	3	invasive	invasive	JJ
cord-006229-7yoilsho	4905	4	imaging	imaging	NN
cord-006229-7yoilsho	4905	5	via	via	IN
cord-006229-7yoilsho	4905	6	micro	micro	NNP
cord-006229-7yoilsho	4905	7	CT	CT	NNP
cord-006229-7yoilsho	4905	8	may	may	MD
cord-006229-7yoilsho	4905	9	offer	offer	VB
cord-006229-7yoilsho	4905	10	an	an	DT
cord-006229-7yoilsho	4905	11	option	option	NN
cord-006229-7yoilsho	4905	12	for	for	IN
cord-006229-7yoilsho	4905	13	longitudinal	longitudinal	JJ
cord-006229-7yoilsho	4905	14	monitoring	monitoring	NN
cord-006229-7yoilsho	4905	15	of	of	IN
cord-006229-7yoilsho	4905	16	the	the	DT
cord-006229-7yoilsho	4905	17	progression	progression	NN
cord-006229-7yoilsho	4905	18	of	of	IN
cord-006229-7yoilsho	4905	19	obliterative	obliterative	JJ
cord-006229-7yoilsho	4905	20	airway	airway	NN
cord-006229-7yoilsho	4905	21	disease	disease	NN
cord-006229-7yoilsho	4905	22	as	as	RB
cord-006229-7yoilsho	4905	23	well	well	RB
cord-006229-7yoilsho	4905	24	as	as	IN
cord-006229-7yoilsho	4905	25	response	response	NN
cord-006229-7yoilsho	4905	26	to	to	IN
cord-006229-7yoilsho	4905	27	treatment	treatment	NN
cord-006229-7yoilsho	4905	28	.	.	.
cord-006229-7yoilsho	4906	1	C.	C.	NNP
cord-006229-7yoilsho	4906	2	elegans	elegan	NNS
cord-006229-7yoilsho	4906	3	is	be	VBZ
cord-006229-7yoilsho	4906	4	a	a	DT
cord-006229-7yoilsho	4906	5	well	well	RB
cord-006229-7yoilsho	4906	6	-	-	HYPH
cord-006229-7yoilsho	4906	7	established	establish	VBN
cord-006229-7yoilsho	4906	8	model	model	NN
cord-006229-7yoilsho	4906	9	organism	organism	NN
cord-006229-7yoilsho	4906	10	to	to	TO
cord-006229-7yoilsho	4906	11	study	study	VB
cord-006229-7yoilsho	4906	12	the	the	DT
cord-006229-7yoilsho	4906	13	aging	aging	NN
cord-006229-7yoilsho	4906	14	process	process	NN
cord-006229-7yoilsho	4906	15	as	as	RB
cord-006229-7yoilsho	4906	16	well	well	RB
cord-006229-7yoilsho	4906	17	as	as	IN
cord-006229-7yoilsho	4906	18	effects	effect	NNS
cord-006229-7yoilsho	4906	19	of	of	IN
cord-006229-7yoilsho	4906	20	various	various	JJ
cord-006229-7yoilsho	4906	21	substances	substance	NNS
cord-006229-7yoilsho	4906	22	in	in	IN
cord-006229-7yoilsho	4906	23	vivo	vivo	NN
cord-006229-7yoilsho	4906	24	.	.	.
cord-006229-7yoilsho	4907	1	Its	-PRON-	PRP$
cord-006229-7yoilsho	4907	2	lifespan	lifespan	NN
cord-006229-7yoilsho	4907	3	is	be	VBZ
cord-006229-7yoilsho	4907	4	regulated	regulate	VBN
cord-006229-7yoilsho	4907	5	by	by	IN
cord-006229-7yoilsho	4907	6	multiple	multiple	JJ
cord-006229-7yoilsho	4907	7	signaling	signal	VBG
cord-006229-7yoilsho	4907	8	pathways	pathway	NNS
cord-006229-7yoilsho	4907	9	(	(	-LRB-
cord-006229-7yoilsho	4907	10	e.g.	e.g.	RB
cord-006229-7yoilsho	4907	11	Insulin	Insulin	NNP
cord-006229-7yoilsho	4907	12	or	or	CC
cord-006229-7yoilsho	4907	13	mTOR	mTOR	NNP
cord-006229-7yoilsho	4907	14	signaling	signal	VBG
cord-006229-7yoilsho	4907	15	)	)	-RRB-
cord-006229-7yoilsho	4907	16	,	,	,
cord-006229-7yoilsho	4907	17	which	which	WDT
cord-006229-7yoilsho	4907	18	are	be	VBP
cord-006229-7yoilsho	4907	19	well	well	RB
cord-006229-7yoilsho	4907	20	conserved	conserve	VBN
cord-006229-7yoilsho	4907	21	up	up	RP
cord-006229-7yoilsho	4907	22	to	to	IN
cord-006229-7yoilsho	4907	23	humans	human	NNS
cord-006229-7yoilsho	4907	24	.	.	.
cord-006229-7yoilsho	4908	1	The	the	DT
cord-006229-7yoilsho	4908	2	insulin	insulin	NN
cord-006229-7yoilsho	4908	3	/	/	SYM
cord-006229-7yoilsho	4908	4	IGF-1	IGF-1	NNP
cord-006229-7yoilsho	4908	5	pathway	pathway	NN
cord-006229-7yoilsho	4908	6	was	be	VBD
cord-006229-7yoilsho	4908	7	the	the	DT
cord-006229-7yoilsho	4908	8	first	first	JJ
cord-006229-7yoilsho	4908	9	pathway	pathway	NN
cord-006229-7yoilsho	4908	10	shown	show	VBN
cord-006229-7yoilsho	4908	11	to	to	TO
cord-006229-7yoilsho	4908	12	effect	effect	VB
cord-006229-7yoilsho	4908	13	ageing	age	VBG
cord-006229-7yoilsho	4908	14	in	in	IN
cord-006229-7yoilsho	4908	15	animals	animal	NNS
cord-006229-7yoilsho	4908	16	.	.	.
cord-006229-7yoilsho	4909	1	Mutations	mutation	NNS
cord-006229-7yoilsho	4909	2	that	that	WDT
cord-006229-7yoilsho	4909	3	decrease	decrease	VBP
cord-006229-7yoilsho	4909	4	the	the	DT
cord-006229-7yoilsho	4909	5	activity	activity	NN
cord-006229-7yoilsho	4909	6	of	of	IN
cord-006229-7yoilsho	4910	1	DAF-2	DAF-2	NNP
cord-006229-7yoilsho	4910	2	(	(	-LRB-
cord-006229-7yoilsho	4910	3	IGF1R	IGF1R	NNS
cord-006229-7yoilsho	4910	4	)	)	-RRB-
cord-006229-7yoilsho	4910	5	lead	lead	VBP
cord-006229-7yoilsho	4910	6	to	to	IN
cord-006229-7yoilsho	4910	7	a	a	DT
cord-006229-7yoilsho	4910	8	significant	significant	JJ
cord-006229-7yoilsho	4910	9	increase	increase	NN
cord-006229-7yoilsho	4910	10	of	of	IN
cord-006229-7yoilsho	4910	11	lifespan	lifespan	NN
cord-006229-7yoilsho	4910	12	accompanied	accompany	VBN
cord-006229-7yoilsho	4910	13	by	by	IN
cord-006229-7yoilsho	4910	14	a	a	DT
cord-006229-7yoilsho	4910	15	decrease	decrease	NN
cord-006229-7yoilsho	4910	16	of	of	IN
cord-006229-7yoilsho	4910	17	age	age	NN
cord-006229-7yoilsho	4910	18	pigment	pigment	NN
cord-006229-7yoilsho	4910	19	accumulation	accumulation	NN
cord-006229-7yoilsho	4910	20	in	in	IN
cord-006229-7yoilsho	4910	21	C.	C.	NNP
cord-006229-7yoilsho	4910	22	elegans	elegan	NNS
cord-006229-7yoilsho	4910	23	.	.	.
cord-006229-7yoilsho	4911	1	The	the	DT
cord-006229-7yoilsho	4911	2	relevant	relevant	JJ
cord-006229-7yoilsho	4911	3	effector	effector	NN
cord-006229-7yoilsho	4911	4	of	of	IN
cord-006229-7yoilsho	4911	5	the	the	DT
cord-006229-7yoilsho	4911	6	insulin	insulin	NN
cord-006229-7yoilsho	4911	7	/	/	SYM
cord-006229-7yoilsho	4911	8	IGF-1	IGF-1	NNP
cord-006229-7yoilsho	4911	9	pathway	pathway	NN
cord-006229-7yoilsho	4911	10	is	be	VBZ
cord-006229-7yoilsho	4911	11	the	the	DT
cord-006229-7yoilsho	4911	12	transcription	transcription	NN
cord-006229-7yoilsho	4911	13	factor	factor	NN
cord-006229-7yoilsho	4911	14	DAF-16	DAF-16	NNP
cord-006229-7yoilsho	4911	15	(	(	-LRB-
cord-006229-7yoilsho	4911	16	hFOXO3a	hFOXO3a	NNP
cord-006229-7yoilsho	4911	17	)	)	-RRB-
cord-006229-7yoilsho	4911	18	.	.	.
cord-006229-7yoilsho	4912	1	Inhibition	inhibition	NN
cord-006229-7yoilsho	4912	2	of	of	IN
cord-006229-7yoilsho	4912	3	HMG	HMG	NNP
cord-006229-7yoilsho	4912	4	-	-	HYPH
cord-006229-7yoilsho	4912	5	CoA	coa	NN
cord-006229-7yoilsho	4912	6	reductase	reductase	NN
cord-006229-7yoilsho	4912	7	(	(	-LRB-
cord-006229-7yoilsho	4912	8	enzyme	enzyme	NN
cord-006229-7yoilsho	4912	9	of	of	IN
cord-006229-7yoilsho	4912	10	mevalonate	mevalonate	NNP
cord-006229-7yoilsho	4912	11	pathway	pathway	NNP
cord-006229-7yoilsho	4912	12	)	)	-RRB-
cord-006229-7yoilsho	4912	13	by	by	IN
cord-006229-7yoilsho	4912	14	statins	statin	NNS
cord-006229-7yoilsho	4912	15	,	,	,
cord-006229-7yoilsho	4912	16	which	which	WDT
cord-006229-7yoilsho	4912	17	are	be	VBP
cord-006229-7yoilsho	4912	18	frequently	frequently	RB
cord-006229-7yoilsho	4912	19	used	use	VBN
cord-006229-7yoilsho	4912	20	as	as	IN
cord-006229-7yoilsho	4912	21	cholesterol	cholesterol	NN
cord-006229-7yoilsho	4912	22	-	-	HYPH
cord-006229-7yoilsho	4912	23	lowering	lower	VBG
cord-006229-7yoilsho	4912	24	agents	agent	NNS
cord-006229-7yoilsho	4912	25	in	in	IN
cord-006229-7yoilsho	4912	26	the	the	DT
cord-006229-7yoilsho	4912	27	clinic	clinic	NN
cord-006229-7yoilsho	4912	28	,	,	,
cord-006229-7yoilsho	4912	29	has	have	VBZ
cord-006229-7yoilsho	4912	30	been	be	VBN
cord-006229-7yoilsho	4912	31	shown	show	VBN
cord-006229-7yoilsho	4912	32	to	to	TO
cord-006229-7yoilsho	4912	33	attenuate	attenuate	VB
cord-006229-7yoilsho	4912	34	protein	protein	NN
cord-006229-7yoilsho	4912	35	prenylation	prenylation	NN
cord-006229-7yoilsho	4912	36	and	and	CC
cord-006229-7yoilsho	4912	37	glycosylation	glycosylation	NN
cord-006229-7yoilsho	4912	38	.	.	.
cord-006229-7yoilsho	4913	1	Notably	notably	RB
cord-006229-7yoilsho	4913	2	,	,	,
cord-006229-7yoilsho	4913	3	prenylated-	prenylated-	NN
cord-006229-7yoilsho	4913	4	,	,	,
cord-006229-7yoilsho	4913	5	membrane	membrane	NN
cord-006229-7yoilsho	4913	6	-	-	HYPH
cord-006229-7yoilsho	4913	7	bound	bind	VBN
cord-006229-7yoilsho	4913	8	small	small	JJ
cord-006229-7yoilsho	4913	9	GTP	gtp	NN
cord-006229-7yoilsho	4913	10	-	-	HYPH
cord-006229-7yoilsho	4913	11	binding	bind	VBG
cord-006229-7yoilsho	4913	12	proteins	protein	NNS
cord-006229-7yoilsho	4913	13	are	be	VBP
cord-006229-7yoilsho	4913	14	important	important	JJ
cord-006229-7yoilsho	4913	15	for	for	IN
cord-006229-7yoilsho	4913	16	the	the	DT
cord-006229-7yoilsho	4913	17	regulation	regulation	NN
cord-006229-7yoilsho	4913	18	of	of	IN
cord-006229-7yoilsho	4913	19	the	the	DT
cord-006229-7yoilsho	4913	20	afore	afore	NN
cord-006229-7yoilsho	4913	21	mentioned	mention	VBN
cord-006229-7yoilsho	4913	22	age	age	NN
cord-006229-7yoilsho	4913	23	-	-	HYPH
cord-006229-7yoilsho	4913	24	related	relate	VBN
cord-006229-7yoilsho	4913	25	signaling	signal	VBG
cord-006229-7yoilsho	4913	26	pathways	pathway	NNS
cord-006229-7yoilsho	4913	27	like	like	IN
cord-006229-7yoilsho	4913	28	the	the	DT
cord-006229-7yoilsho	4913	29	insulin	insulin	NN
cord-006229-7yoilsho	4913	30	/	/	SYM
cord-006229-7yoilsho	4913	31	IGF-1	IGF-1	NNP
cord-006229-7yoilsho	4913	32	pathway	pathway	NN
cord-006229-7yoilsho	4913	33	.	.	.
cord-006229-7yoilsho	4914	1	Recently	recently	RB
cord-006229-7yoilsho	4914	2	,	,	,
cord-006229-7yoilsho	4914	3	a	a	DT
cord-006229-7yoilsho	4914	4	cohort	cohort	NN
cord-006229-7yoilsho	4914	5	study	study	NN
cord-006229-7yoilsho	4914	6	showed	show	VBD
cord-006229-7yoilsho	4914	7	that	that	IN
cord-006229-7yoilsho	4914	8	a	a	DT
cord-006229-7yoilsho	4914	9	decreased	decrease	VBN
cord-006229-7yoilsho	4914	10	mortality	mortality	NN
cord-006229-7yoilsho	4914	11	rate	rate	NN
cord-006229-7yoilsho	4914	12	in	in	IN
cord-006229-7yoilsho	4914	13	humans	human	NNS
cord-006229-7yoilsho	4914	14	between	between	IN
cord-006229-7yoilsho	4914	15	age	age	NN
cord-006229-7yoilsho	4914	16	78	78	CD
cord-006229-7yoilsho	4914	17	-90	-90	NN
cord-006229-7yoilsho	4914	18	correlates	correlate	VBZ
cord-006229-7yoilsho	4914	19	with	with	IN
cord-006229-7yoilsho	4914	20	statin	statin	NN
cord-006229-7yoilsho	4914	21	treatment	treatment	NN
cord-006229-7yoilsho	4914	22	,	,	,
cord-006229-7yoilsho	4914	23	but	but	CC
cord-006229-7yoilsho	4914	24	is	be	VBZ
cord-006229-7yoilsho	4914	25	independent	independent	JJ
cord-006229-7yoilsho	4914	26	of	of	IN
cord-006229-7yoilsho	4914	27	total	total	JJ
cord-006229-7yoilsho	4914	28	cholesterol	cholesterol	NN
cord-006229-7yoilsho	4914	29	levels	level	NNS
cord-006229-7yoilsho	4914	30	.	.	.
cord-006229-7yoilsho	4915	1	As	as	IN
cord-006229-7yoilsho	4915	2	C.	C.	NNP
cord-006229-7yoilsho	4915	3	elegans	elegan	NNS
cord-006229-7yoilsho	4915	4	harbors	harbor	VBZ
cord-006229-7yoilsho	4915	5	the	the	DT
cord-006229-7yoilsho	4915	6	mevalonate	mevalonate	NNP
cord-006229-7yoilsho	4915	7	pathway	pathway	NN
cord-006229-7yoilsho	4915	8	,	,	,
cord-006229-7yoilsho	4915	9	but	but	CC
cord-006229-7yoilsho	4915	10	the	the	DT
cord-006229-7yoilsho	4915	11	branch	branch	NN
cord-006229-7yoilsho	4915	12	leading	lead	VBG
cord-006229-7yoilsho	4915	13	to	to	IN
cord-006229-7yoilsho	4915	14	cholesterol	cholesterol	NN
cord-006229-7yoilsho	4915	15	synthesis	synthesis	NN
cord-006229-7yoilsho	4915	16	is	be	VBZ
cord-006229-7yoilsho	4915	17	missing	miss	VBG
cord-006229-7yoilsho	4915	18	,	,	,
cord-006229-7yoilsho	4915	19	it	-PRON-	PRP
cord-006229-7yoilsho	4915	20	is	be	VBZ
cord-006229-7yoilsho	4915	21	a	a	DT
cord-006229-7yoilsho	4915	22	well	well	RB
cord-006229-7yoilsho	4915	23	-	-	HYPH
cord-006229-7yoilsho	4915	24	suited	suit	VBN
cord-006229-7yoilsho	4915	25	model	model	NN
cord-006229-7yoilsho	4915	26	to	to	TO
cord-006229-7yoilsho	4915	27	study	study	VB
cord-006229-7yoilsho	4915	28	cholesterol	cholesterol	NN
cord-006229-7yoilsho	4915	29	-independent	-independent	JJ
cord-006229-7yoilsho	4915	30	effects	effect	NNS
cord-006229-7yoilsho	4915	31	of	of	IN
cord-006229-7yoilsho	4915	32	statins	statin	NNS
cord-006229-7yoilsho	4915	33	on	on	IN
cord-006229-7yoilsho	4915	34	aging	age	VBG
cord-006229-7yoilsho	4915	35	-	-	HYPH
cord-006229-7yoilsho	4915	36	associated	associate	VBN
cord-006229-7yoilsho	4915	37	phenotypes	phenotype	NNS
cord-006229-7yoilsho	4915	38	and	and	CC
cord-006229-7yoilsho	4915	39	the	the	DT
cord-006229-7yoilsho	4915	40	underlying	underlying	JJ
cord-006229-7yoilsho	4915	41	molecular	molecular	JJ
cord-006229-7yoilsho	4915	42	mechanisms	mechanism	NNS
cord-006229-7yoilsho	4915	43	.	.	.
cord-006229-7yoilsho	4916	1	Here	here	RB
cord-006229-7yoilsho	4916	2	,	,	,
cord-006229-7yoilsho	4916	3	we	-PRON-	PRP
cord-006229-7yoilsho	4916	4	show	show	VBP
cord-006229-7yoilsho	4916	5	that	that	IN
cord-006229-7yoilsho	4916	6	exposure	exposure	NN
cord-006229-7yoilsho	4916	7	of	of	IN
cord-006229-7yoilsho	4916	8	C.	C.	NNP
cord-006229-7yoilsho	4916	9	elegans	elegan	NNS
cord-006229-7yoilsho	4916	10	to	to	IN
cord-006229-7yoilsho	4916	11	statins	statin	NNS
cord-006229-7yoilsho	4916	12	substantially	substantially	RB
cord-006229-7yoilsho	4916	13	decelerated	decelerate	VBD
cord-006229-7yoilsho	4916	14	the	the	DT
cord-006229-7yoilsho	4916	15	accumulation	accumulation	NN
cord-006229-7yoilsho	4916	16	of	of	IN
cord-006229-7yoilsho	4916	17	age	age	NN
cord-006229-7yoilsho	4916	18	pigments	pigment	NNS
cord-006229-7yoilsho	4916	19	.	.	.
cord-006229-7yoilsho	4917	1	While	while	IN
cord-006229-7yoilsho	4917	2	the	the	DT
cord-006229-7yoilsho	4917	3	level	level	NN
cord-006229-7yoilsho	4917	4	of	of	IN
cord-006229-7yoilsho	4917	5	age	age	NN
cord-006229-7yoilsho	4917	6	pigments	pigment	NNS
cord-006229-7yoilsho	4917	7	roughly	roughly	RB
cord-006229-7yoilsho	4917	8	doubled	double	VBD
cord-006229-7yoilsho	4917	9	in	in	IN
cord-006229-7yoilsho	4917	10	control	control	NN
cord-006229-7yoilsho	4917	11	animals	animal	NNS
cord-006229-7yoilsho	4917	12	,	,	,
cord-006229-7yoilsho	4917	13	there	there	EX
cord-006229-7yoilsho	4917	14	was	be	VBD
cord-006229-7yoilsho	4917	15	only	only	RB
cord-006229-7yoilsho	4917	16	a	a	DT
cord-006229-7yoilsho	4917	17	slight	slight	JJ
cord-006229-7yoilsho	4917	18	increase	increase	NN
cord-006229-7yoilsho	4917	19	in	in	IN
cord-006229-7yoilsho	4917	20	the	the	DT
cord-006229-7yoilsho	4917	21	lovastatin	lovastatin	NNP
cord-006229-7yoilsho	4917	22	group	group	NN
cord-006229-7yoilsho	4917	23	.	.	.
cord-006229-7yoilsho	4918	1	The	the	DT
cord-006229-7yoilsho	4918	2	use	use	NN
cord-006229-7yoilsho	4918	3	of	of	IN
cord-006229-7yoilsho	4918	4	atorvastatin	atorvastatin	NNP
cord-006229-7yoilsho	4918	5	gave	give	VBD
cord-006229-7yoilsho	4918	6	comparable	comparable	JJ
cord-006229-7yoilsho	4918	7	results	result	NNS
cord-006229-7yoilsho	4918	8	indicating	indicate	VBG
cord-006229-7yoilsho	4918	9	a	a	DT
cord-006229-7yoilsho	4918	10	more	more	RBR
cord-006229-7yoilsho	4918	11	general	general	JJ
cord-006229-7yoilsho	4918	12	effect	effect	NN
cord-006229-7yoilsho	4918	13	of	of	IN
cord-006229-7yoilsho	4918	14	the	the	DT
cord-006229-7yoilsho	4918	15	inhibition	inhibition	NN
cord-006229-7yoilsho	4918	16	of	of	IN
cord-006229-7yoilsho	4918	17	the	the	DT
cord-006229-7yoilsho	4918	18	HMG	HMG	NNP
cord-006229-7yoilsho	4918	19	-	-	HYPH
cord-006229-7yoilsho	4918	20	CoA	coa	NN
cord-006229-7yoilsho	4918	21	reductase	reductase	NN
cord-006229-7yoilsho	4918	22	.	.	.
cord-006229-7yoilsho	4919	1	The	the	DT
cord-006229-7yoilsho	4919	2	retarded	retarded	JJ
cord-006229-7yoilsho	4919	3	accumulation	accumulation	NN
cord-006229-7yoilsho	4919	4	of	of	IN
cord-006229-7yoilsho	4919	5	age	age	NN
cord-006229-7yoilsho	4919	6	pigments	pigment	NNS
cord-006229-7yoilsho	4919	7	could	could	MD
cord-006229-7yoilsho	4919	8	be	be	VB
cord-006229-7yoilsho	4919	9	partly	partly	RB
cord-006229-7yoilsho	4919	10	phenocopied	phenocopie	VBN
cord-006229-7yoilsho	4919	11	using	use	VBG
cord-006229-7yoilsho	4919	12	an	an	DT
cord-006229-7yoilsho	4919	13	inhibitor	inhibitor	NN
cord-006229-7yoilsho	4919	14	of	of	IN
cord-006229-7yoilsho	4919	15	the	the	DT
cord-006229-7yoilsho	4919	16	small	small	JJ
cord-006229-7yoilsho	4919	17	GTPase	GTPase	NNP
cord-006229-7yoilsho	4919	18	Rac1	Rac1	NNP
cord-006229-7yoilsho	4919	19	or	or	CC
cord-006229-7yoilsho	4919	20	using	use	VBG
cord-006229-7yoilsho	4919	21	RNAi	RNAi	NNS
cord-006229-7yoilsho	4919	22	against	against	IN
cord-006229-7yoilsho	4919	23	the	the	DT
cord-006229-7yoilsho	4919	24	HMG	HMG	NNP
cord-006229-7yoilsho	4919	25	-	-	HYPH
cord-006229-7yoilsho	4919	26	CoA	coa	NN
cord-006229-7yoilsho	4919	27	reductase	reductase	NN
cord-006229-7yoilsho	4919	28	.	.	.
cord-006229-7yoilsho	4920	1	A	a	DT
cord-006229-7yoilsho	4920	2	reduced	reduced	JJ
cord-006229-7yoilsho	4920	3	level	level	NN
cord-006229-7yoilsho	4920	4	of	of	IN
cord-006229-7yoilsho	4920	5	age	age	NN
cord-006229-7yoilsho	4920	6	pigments	pigment	NNS
cord-006229-7yoilsho	4920	7	is	be	VBZ
cord-006229-7yoilsho	4920	8	prognostic	prognostic	JJ
cord-006229-7yoilsho	4920	9	for	for	IN
cord-006229-7yoilsho	4920	10	an	an	DT
cord-006229-7yoilsho	4920	11	elevated	elevated	JJ
cord-006229-7yoilsho	4920	12	mean	mean	JJ
cord-006229-7yoilsho	4920	13	lifespan	lifespan	NN
cord-006229-7yoilsho	4920	14	(	(	-LRB-
cord-006229-7yoilsho	4920	15	about	about	RB
cord-006229-7yoilsho	4920	16	20	20	CD
cord-006229-7yoilsho	4920	17	%	%	NN
cord-006229-7yoilsho	4920	18	)	)	-RRB-
cord-006229-7yoilsho	4920	19	in	in	IN
cord-006229-7yoilsho	4920	20	C.	C.	NNP
cord-006229-7yoilsho	4920	21	elegans	elegan	NNS
cord-006229-7yoilsho	4920	22	.	.	.
cord-006229-7yoilsho	4921	1	A	a	DT
cord-006229-7yoilsho	4921	2	post	post	JJ
cord-006229-7yoilsho	4921	3	reproductive	reproductive	JJ
cord-006229-7yoilsho	4921	4	treatment	treatment	NN
cord-006229-7yoilsho	4921	5	with	with	IN
cord-006229-7yoilsho	4921	6	lovastatin	lovastatin	NN
cord-006229-7yoilsho	4921	7	,	,	,
cord-006229-7yoilsho	4921	8	mimicking	mimic	VBG
cord-006229-7yoilsho	4921	9	the	the	DT
cord-006229-7yoilsho	4921	10	use	use	NN
cord-006229-7yoilsho	4921	11	of	of	IN
cord-006229-7yoilsho	4921	12	statins	statin	NNS
cord-006229-7yoilsho	4921	13	in	in	IN
cord-006229-7yoilsho	4921	14	patients	patient	NNS
cord-006229-7yoilsho	4921	15	of	of	IN
cord-006229-7yoilsho	4921	16	advanced	advanced	JJ
cord-006229-7yoilsho	4921	17	age	age	NN
cord-006229-7yoilsho	4921	18	increased	increase	VBD
cord-006229-7yoilsho	4921	19	the	the	DT
cord-006229-7yoilsho	4921	20	mean	mean	JJ
cord-006229-7yoilsho	4921	21	lifespan	lifespan	NN
cord-006229-7yoilsho	4921	22	in	in	IN
cord-006229-7yoilsho	4921	23	C.	C.	NNP
cord-006229-7yoilsho	4921	24	elegans	elegan	NNS
cord-006229-7yoilsho	4921	25	even	even	RB
cord-006229-7yoilsho	4921	26	further	further	RB
cord-006229-7yoilsho	4921	27	.	.	.
cord-006229-7yoilsho	4922	1	In	in	IN
cord-006229-7yoilsho	4922	2	addition	addition	NN
cord-006229-7yoilsho	4922	3	,	,	,
cord-006229-7yoilsho	4922	4	we	-PRON-	PRP
cord-006229-7yoilsho	4922	5	could	could	MD
cord-006229-7yoilsho	4922	6	show	show	VB
cord-006229-7yoilsho	4922	7	a	a	DT
cord-006229-7yoilsho	4922	8	mild	mild	JJ
cord-006229-7yoilsho	4922	9	reduction	reduction	NN
cord-006229-7yoilsho	4922	10	of	of	IN
cord-006229-7yoilsho	4922	11	fertility	fertility	NN
cord-006229-7yoilsho	4922	12	and	and	CC
cord-006229-7yoilsho	4922	13	a	a	DT
cord-006229-7yoilsho	4922	14	developmental	developmental	JJ
cord-006229-7yoilsho	4922	15	delay	delay	NN
cord-006229-7yoilsho	4922	16	as	as	RB
cord-006229-7yoilsho	4922	17	well	well	RB
cord-006229-7yoilsho	4922	18	as	as	IN
cord-006229-7yoilsho	4922	19	a	a	DT
cord-006229-7yoilsho	4922	20	marked	marked	JJ
cord-006229-7yoilsho	4922	21	increase	increase	NN
cord-006229-7yoilsho	4922	22	in	in	IN
cord-006229-7yoilsho	4922	23	acute	acute	JJ
cord-006229-7yoilsho	4922	24	thermal	thermal	JJ
cord-006229-7yoilsho	4922	25	stress	stress	NN
cord-006229-7yoilsho	4922	26	resistance	resistance	NN
cord-006229-7yoilsho	4922	27	mediated	mediate	VBN
cord-006229-7yoilsho	4922	28	by	by	IN
cord-006229-7yoilsho	4922	29	lovastatin	lovastatin	NN
cord-006229-7yoilsho	4922	30	.	.	.
cord-006229-7yoilsho	4923	1	Besides	besides	IN
cord-006229-7yoilsho	4923	2	the	the	DT
cord-006229-7yoilsho	4923	3	reduced	reduce	VBN
cord-006229-7yoilsho	4923	4	accumulation	accumulation	NN
cord-006229-7yoilsho	4923	5	of	of	IN
cord-006229-7yoilsho	4923	6	age	age	NN
cord-006229-7yoilsho	4923	7	pigments	pigment	NNS
cord-006229-7yoilsho	4923	8	and	and	CC
cord-006229-7yoilsho	4923	9	the	the	DT
cord-006229-7yoilsho	4923	10	increased	increase	VBN
cord-006229-7yoilsho	4923	11	lifespan	lifespan	NN
cord-006229-7yoilsho	4923	12	these	these	DT
cord-006229-7yoilsho	4923	13	are	be	VBP
cord-006229-7yoilsho	4923	14	phenotypes	phenotype	NNS
cord-006229-7yoilsho	4923	15	which	which	WDT
cord-006229-7yoilsho	4923	16	are	be	VBP
cord-006229-7yoilsho	4923	17	usually	usually	RB
cord-006229-7yoilsho	4923	18	observed	observe	VBN
cord-006229-7yoilsho	4923	19	under	under	IN
cord-006229-7yoilsho	4923	20	accumulation	accumulation	NN
cord-006229-7yoilsho	4923	21	of	of	IN
cord-006229-7yoilsho	4923	22	DAF-16	DAF-16	NNP
cord-006229-7yoilsho	4923	23	overactivity	overactivity	NN
cord-006229-7yoilsho	4923	24	.	.	.
cord-006229-7yoilsho	4924	1	Consequently	consequently	RB
cord-006229-7yoilsho	4924	2	we	-PRON-	PRP
cord-006229-7yoilsho	4924	3	found	find	VBD
cord-006229-7yoilsho	4924	4	an	an	DT
cord-006229-7yoilsho	4924	5	increased	increase	VBN
cord-006229-7yoilsho	4924	6	nuclear	nuclear	JJ
cord-006229-7yoilsho	4924	7	localization	localization	NN
cord-006229-7yoilsho	4924	8	of	of	IN
cord-006229-7yoilsho	4924	9	DAF-16	DAF-16	NNP
cord-006229-7yoilsho	4924	10	in	in	IN
cord-006229-7yoilsho	4924	11	the	the	DT
cord-006229-7yoilsho	4924	12	presence	presence	NN
cord-006229-7yoilsho	4924	13	of	of	IN
cord-006229-7yoilsho	4924	14	lovastatin	lovastatin	NN
cord-006229-7yoilsho	4924	15	and	and	CC
cord-006229-7yoilsho	4924	16	lovastatin	lovastatin	NN
cord-006229-7yoilsho	4924	17	completely	completely	RB
cord-006229-7yoilsho	4924	18	failed	fail	VBD
cord-006229-7yoilsho	4924	19	to	to	TO
cord-006229-7yoilsho	4924	20	reduce	reduce	VB
cord-006229-7yoilsho	4924	21	age	age	NN
cord-006229-7yoilsho	4924	22	pigments	pigment	NNS
cord-006229-7yoilsho	4924	23	in	in	IN
cord-006229-7yoilsho	4924	24	a	a	DT
cord-006229-7yoilsho	4924	25	daf-16-KO	daf-16-ko	NN
cord-006229-7yoilsho	4924	26	mutant	mutant	JJ
cord-006229-7yoilsho	4924	27	background	background	NN
cord-006229-7yoilsho	4924	28	.	.	.
cord-006229-7yoilsho	4925	1	RT	RT	NNP
cord-006229-7yoilsho	4925	2	-	-	HYPH
cord-006229-7yoilsho	4925	3	qPCR	qPCR	NNP
cord-006229-7yoilsho	4925	4	brought	bring	VBD
cord-006229-7yoilsho	4925	5	JNK-1	JNK-1	NNP
cord-006229-7yoilsho	4925	6	,	,	,
cord-006229-7yoilsho	4925	7	a	a	DT
cord-006229-7yoilsho	4925	8	known	know	VBN
cord-006229-7yoilsho	4925	9	activator	activator	NN
cord-006229-7yoilsho	4925	10	of	of	IN
cord-006229-7yoilsho	4925	11	DAF-16	DAF-16	NNP
cord-006229-7yoilsho	4925	12	,	,	,
cord-006229-7yoilsho	4925	13	into	into	IN
cord-006229-7yoilsho	4925	14	play	play	NN
cord-006229-7yoilsho	4925	15	as	as	IN
cord-006229-7yoilsho	4925	16	a	a	DT
cord-006229-7yoilsho	4925	17	possible	possible	JJ
cord-006229-7yoilsho	4925	18	effector	effector	NN
cord-006229-7yoilsho	4925	19	induced	induce	VBN
cord-006229-7yoilsho	4925	20	by	by	IN
cord-006229-7yoilsho	4925	21	statins	statin	NNS
cord-006229-7yoilsho	4925	22	.	.	.
cord-006229-7yoilsho	4926	1	This	this	DT
cord-006229-7yoilsho	4926	2	is	be	VBZ
cord-006229-7yoilsho	4926	3	currently	currently	RB
cord-006229-7yoilsho	4926	4	under	under	IN
cord-006229-7yoilsho	4926	5	investigation	investigation	NN
cord-006229-7yoilsho	4926	6	.	.	.
cord-006229-7yoilsho	4927	1	In	in	IN
cord-006229-7yoilsho	4927	2	summary	summary	NN
cord-006229-7yoilsho	4927	3	,	,	,
cord-006229-7yoilsho	4927	4	statin	statin	NN
cord-006229-7yoilsho	4927	5	exposure	exposure	NN
cord-006229-7yoilsho	4927	6	induces	induce	VBZ
cord-006229-7yoilsho	4927	7	a	a	DT
cord-006229-7yoilsho	4927	8	longevity	longevity	NN
cord-006229-7yoilsho	4927	9	phenotype	phenotype	NN
cord-006229-7yoilsho	4927	10	in	in	IN
cord-006229-7yoilsho	4927	11	C.	C.	NNP
cord-006229-7yoilsho	4927	12	elegans	elegan	NNS
cord-006229-7yoilsho	4927	13	,	,	,
cord-006229-7yoilsho	4927	14	which	which	WDT
cord-006229-7yoilsho	4927	15	might	may	MD
cord-006229-7yoilsho	4927	16	be	be	VB
cord-006229-7yoilsho	4927	17	DAF-16	DAF-16	NNP
cord-006229-7yoilsho	4927	18	dependent	dependent	JJ
cord-006229-7yoilsho	4927	19	.	.	.
cord-006229-7yoilsho	4928	1	This	this	DT
cord-006229-7yoilsho	4928	2	findings	finding	NNS
cord-006229-7yoilsho	4928	3	indicates	indicate	VBZ
cord-006229-7yoilsho	4928	4	that	that	IN
cord-006229-7yoilsho	4928	5	a	a	DT
cord-006229-7yoilsho	4928	6	product	product	NN
cord-006229-7yoilsho	4928	7	of	of	IN
cord-006229-7yoilsho	4928	8	the	the	DT
cord-006229-7yoilsho	4928	9	mevalonate	mevalonate	NNP
cord-006229-7yoilsho	4928	10	pathway	pathway	NN
cord-006229-7yoilsho	4928	11	might	may	MD
cord-006229-7yoilsho	4928	12	influence	influence	VB
cord-006229-7yoilsho	4928	13	the	the	DT
cord-006229-7yoilsho	4928	14	insulin	insulin	NN
cord-006229-7yoilsho	4928	15	/	/	SYM
cord-006229-7yoilsho	4928	16	IGF-1	IGF-1	NNP
cord-006229-7yoilsho	4928	17	pathway	pathway	NN
cord-006229-7yoilsho	4928	18	and	and	CC
cord-006229-7yoilsho	4928	19	particularly	particularly	RB
cord-006229-7yoilsho	4928	20	the	the	DT
cord-006229-7yoilsho	4928	21	transcription	transcription	NN
cord-006229-7yoilsho	4928	22	factor	factor	NN
cord-006229-7yoilsho	4928	23	DAF-16	DAF-16	NNP
cord-006229-7yoilsho	4928	24	.	.	.
cord-006229-7yoilsho	4929	1	The	the	DT
cord-006229-7yoilsho	4929	2	high	high	JJ
cord-006229-7yoilsho	4929	3	-	-	HYPH
cord-006229-7yoilsho	4929	4	fat	fat	NN
cord-006229-7yoilsho	4929	5	diet	diet	NN
cord-006229-7yoilsho	4929	6	(	(	-LRB-
cord-006229-7yoilsho	4929	7	HFD)-fed	HFD)-fed	NNP
cord-006229-7yoilsho	4929	8	,	,	,
cord-006229-7yoilsho	4929	9	streptozotocin	streptozotocin	NNS
cord-006229-7yoilsho	4929	10	(	(	-LRB-
cord-006229-7yoilsho	4929	11	STZ)-treated	stz)-treate	VBN
cord-006229-7yoilsho	4929	12	rat	rat	NN
cord-006229-7yoilsho	4929	13	model	model	NN
cord-006229-7yoilsho	4929	14	is	be	VBZ
cord-006229-7yoilsho	4929	15	one	one	CD
cord-006229-7yoilsho	4929	16	of	of	IN
cord-006229-7yoilsho	4929	17	the	the	DT
cord-006229-7yoilsho	4929	18	experimentally	experimentally	RB
cord-006229-7yoilsho	4929	19	-	-	HYPH
cord-006229-7yoilsho	4929	20	induced	induce	VBN
cord-006229-7yoilsho	4929	21	animal	animal	NN
cord-006229-7yoilsho	4929	22	models	model	NNS
cord-006229-7yoilsho	4929	23	of	of	IN
cord-006229-7yoilsho	4929	24	diabetes	diabete	NNS
cord-006229-7yoilsho	4929	25	.	.	.
cord-006229-7yoilsho	4930	1	This	this	DT
cord-006229-7yoilsho	4930	2	model	model	NN
cord-006229-7yoilsho	4930	3	is	be	VBZ
cord-006229-7yoilsho	4930	4	often	often	RB
cord-006229-7yoilsho	4930	5	used	use	VBN
cord-006229-7yoilsho	4930	6	to	to	TO
cord-006229-7yoilsho	4930	7	evaluate	evaluate	VB
cord-006229-7yoilsho	4930	8	the	the	DT
cord-006229-7yoilsho	4930	9	antidiabetic	antidiabetic	JJ
cord-006229-7yoilsho	4930	10	activity	activity	NN
cord-006229-7yoilsho	4930	11	of	of	IN
cord-006229-7yoilsho	4930	12	several	several	JJ
cord-006229-7yoilsho	4930	13	agents	agent	NNS
cord-006229-7yoilsho	4930	14	.	.	.
cord-006229-7yoilsho	4931	1	According	accord	VBG
cord-006229-7yoilsho	4931	2	to	to	IN
cord-006229-7yoilsho	4931	3	Srinivasan	Srinivasan	NNP
cord-006229-7yoilsho	4931	4	et	et	NNP
cord-006229-7yoilsho	4931	5	al	al	NNP
cord-006229-7yoilsho	4931	6	.	.	.
cord-006229-7yoilsho	4932	1	(	(	-LRB-
cord-006229-7yoilsho	4932	2	2005	2005	CD
cord-006229-7yoilsho	4932	3	)	)	-RRB-
cord-006229-7yoilsho	4932	4	,	,	,
cord-006229-7yoilsho	4932	5	prolonged	prolong	VBN
cord-006229-7yoilsho	4932	6	exposure	exposure	NN
cord-006229-7yoilsho	4932	7	of	of	IN
cord-006229-7yoilsho	4932	8	high	high	JJ
cord-006229-7yoilsho	4932	9	-	-	HYPH
cord-006229-7yoilsho	4932	10	fat	fat	NN
cord-006229-7yoilsho	4932	11	diet	diet	NN
cord-006229-7yoilsho	4932	12	leads	lead	VBZ
cord-006229-7yoilsho	4932	13	to	to	IN
cord-006229-7yoilsho	4932	14	insulin	insulin	NN
cord-006229-7yoilsho	4932	15	resistance	resistance	NN
cord-006229-7yoilsho	4932	16	,	,	,
cord-006229-7yoilsho	4932	17	and	and	CC
cord-006229-7yoilsho	4932	18	the	the	DT
cord-006229-7yoilsho	4932	19	development	development	NN
cord-006229-7yoilsho	4932	20	of	of	IN
cord-006229-7yoilsho	4932	21	diabetes	diabetes	NN
cord-006229-7yoilsho	4932	22	occurs	occur	VBZ
cord-006229-7yoilsho	4932	23	only	only	RB
cord-006229-7yoilsho	4932	24	in	in	IN
cord-006229-7yoilsho	4932	25	insulin	insulin	NN
cord-006229-7yoilsho	4932	26	-	-	HYPH
cord-006229-7yoilsho	4932	27	resistant	resistant	JJ
cord-006229-7yoilsho	4932	28	HFD	HFD	NNP
cord-006229-7yoilsho	4932	29	-	-	HYPH
cord-006229-7yoilsho	4932	30	fed	feed	VBN
cord-006229-7yoilsho	4932	31	rats	rat	NNS
cord-006229-7yoilsho	4932	32	following	follow	VBG
cord-006229-7yoilsho	4932	33	low	low	JJ
cord-006229-7yoilsho	4932	34	dose	dose	NN
cord-006229-7yoilsho	4932	35	STZ	STZ	NNP
cord-006229-7yoilsho	4932	36	,	,	,
cord-006229-7yoilsho	4932	37	because	because	IN
cord-006229-7yoilsho	4932	38	the	the	DT
cord-006229-7yoilsho	4932	39	HFD	HFD	NNP
cord-006229-7yoilsho	4932	40	-	-	HYPH
cord-006229-7yoilsho	4932	41	fed	feed	VBN
cord-006229-7yoilsho	4932	42	rats	rat	NNS
cord-006229-7yoilsho	4932	43	are	be	VBP
cord-006229-7yoilsho	4932	44	already	already	RB
cord-006229-7yoilsho	4932	45	mildly	mildly	RB
cord-006229-7yoilsho	4932	46	hyperglycemic	hyperglycemic	JJ
cord-006229-7yoilsho	4932	47	due	due	IN
cord-006229-7yoilsho	4932	48	to	to	IN
cord-006229-7yoilsho	4932	49	insulin	insulin	NN
cord-006229-7yoilsho	4932	50	resistance	resistance	NN
cord-006229-7yoilsho	4932	51	(	(	-LRB-
cord-006229-7yoilsho	4932	52	1	1	CD
cord-006229-7yoilsho	4932	53	)	)	-RRB-
cord-006229-7yoilsho	4932	54	.	.	.
cord-006229-7yoilsho	4933	1	In	in	IN
cord-006229-7yoilsho	4933	2	HFD	HFD	NNP
cord-006229-7yoilsho	4933	3	/	/	SYM
cord-006229-7yoilsho	4933	4	STZ	STZ	NNP
cord-006229-7yoilsho	4933	5	model	model	NN
cord-006229-7yoilsho	4933	6	,	,	,
cord-006229-7yoilsho	4933	7	the	the	DT
cord-006229-7yoilsho	4933	8	rats	rat	NNS
cord-006229-7yoilsho	4933	9	are	be	VBP
cord-006229-7yoilsho	4933	10	fed	feed	VBN
cord-006229-7yoilsho	4933	11	with	with	IN
cord-006229-7yoilsho	4933	12	high	high	JJ
cord-006229-7yoilsho	4933	13	-	-	HYPH
cord-006229-7yoilsho	4933	14	fat	fat	NN
cord-006229-7yoilsho	4933	15	diet	diet	NN
cord-006229-7yoilsho	4933	16	for	for	IN
cord-006229-7yoilsho	4933	17	2	2	CD
cord-006229-7yoilsho	4933	18	-	-	SYM
cord-006229-7yoilsho	4933	19	4	4	CD
cord-006229-7yoilsho	4933	20	weeks	week	NNS
cord-006229-7yoilsho	4933	21	or	or	CC
cord-006229-7yoilsho	4933	22	for	for	IN
cord-006229-7yoilsho	4933	23	a	a	DT
cord-006229-7yoilsho	4933	24	relatively	relatively	RB
cord-006229-7yoilsho	4933	25	long	long	JJ
cord-006229-7yoilsho	4933	26	time	time	NN
cord-006229-7yoilsho	4933	27	(	(	-LRB-
cord-006229-7yoilsho	4933	28	≥	≥	CD
cord-006229-7yoilsho	4933	29	3	3	CD
cord-006229-7yoilsho	4933	30	months	month	NNS
cord-006229-7yoilsho	4933	31	)	)	-RRB-
cord-006229-7yoilsho	4933	32	in	in	IN
cord-006229-7yoilsho	4933	33	order	order	NN
cord-006229-7yoilsho	4933	34	to	to	TO
cord-006229-7yoilsho	4933	35	simulate	simulate	VB
cord-006229-7yoilsho	4933	36	the	the	DT
cord-006229-7yoilsho	4933	37	insulin	insulin	NN
cord-006229-7yoilsho	4933	38	resistance	resistance	NN
cord-006229-7yoilsho	4933	39	and/or	and/or	CC
cord-006229-7yoilsho	4933	40	glucose	glucose	NN
cord-006229-7yoilsho	4933	41	intolerance	intolerance	NN
cord-006229-7yoilsho	4933	42	.	.	.
cord-006229-7yoilsho	4934	1	After	after	IN
cord-006229-7yoilsho	4934	2	induction	induction	NN
cord-006229-7yoilsho	4934	3	of	of	IN
cord-006229-7yoilsho	4934	4	diabetes	diabetes	NN
cord-006229-7yoilsho	4934	5	with	with	IN
cord-006229-7yoilsho	4934	6	multiple	multiple	JJ
cord-006229-7yoilsho	4934	7	or	or	CC
cord-006229-7yoilsho	4934	8	single	single	JJ
cord-006229-7yoilsho	4934	9	low	low	JJ
cord-006229-7yoilsho	4934	10	-	-	HYPH
cord-006229-7yoilsho	4934	11	dose	dose	NN
cord-006229-7yoilsho	4934	12	of	of	IN
cord-006229-7yoilsho	4934	13	STZ	STZ	NNP
cord-006229-7yoilsho	4934	14	(	(	-LRB-
cord-006229-7yoilsho	4934	15	30	30	CD
cord-006229-7yoilsho	4934	16	-	-	SYM
cord-006229-7yoilsho	4934	17	35	35	CD
cord-006229-7yoilsho	4934	18	mg	mg	NNP
cord-006229-7yoilsho	4934	19	/	/	SYM
cord-006229-7yoilsho	4934	20	kg	kg	NNP
cord-006229-7yoilsho	4934	21	)	)	-RRB-
cord-006229-7yoilsho	4934	22	,	,	,
cord-006229-7yoilsho	4934	23	some	some	DT
cord-006229-7yoilsho	4934	24	of	of	IN
cord-006229-7yoilsho	4934	25	the	the	DT
cord-006229-7yoilsho	4934	26	diabetic	diabetic	JJ
cord-006229-7yoilsho	4934	27	rats	rat	NNS
cord-006229-7yoilsho	4934	28	receive	receive	VBP
cord-006229-7yoilsho	4934	29	treatment	treatment	NN
cord-006229-7yoilsho	4934	30	(	(	-LRB-
cord-006229-7yoilsho	4934	31	2	2	CD
cord-006229-7yoilsho	4934	32	)	)	-RRB-
cord-006229-7yoilsho	4934	33	.	.	.
cord-006229-7yoilsho	4935	1	In	in	IN
cord-006229-7yoilsho	4935	2	this	this	DT
cord-006229-7yoilsho	4935	3	way	way	NN
cord-006229-7yoilsho	4935	4	,	,	,
cord-006229-7yoilsho	4935	5	the	the	DT
cord-006229-7yoilsho	4935	6	impact	impact	NN
cord-006229-7yoilsho	4935	7	of	of	IN
cord-006229-7yoilsho	4935	8	treatment	treatment	NN
cord-006229-7yoilsho	4935	9	can	can	MD
cord-006229-7yoilsho	4935	10	be	be	VB
cord-006229-7yoilsho	4935	11	determined	determine	VBN
cord-006229-7yoilsho	4935	12	by	by	IN
cord-006229-7yoilsho	4935	13	comparing	compare	VBG
cord-006229-7yoilsho	4935	14	the	the	DT
cord-006229-7yoilsho	4935	15	differences	difference	NNS
cord-006229-7yoilsho	4935	16	between	between	IN
cord-006229-7yoilsho	4935	17	groups	group	NNS
cord-006229-7yoilsho	4935	18	.	.	.
cord-006229-7yoilsho	4936	1	Despite	despite	IN
cord-006229-7yoilsho	4936	2	the	the	DT
cord-006229-7yoilsho	4936	3	lack	lack	NN
cord-006229-7yoilsho	4936	4	of	of	IN
cord-006229-7yoilsho	4936	5	methodological	methodological	JJ
cord-006229-7yoilsho	4936	6	information	information	NN
cord-006229-7yoilsho	4936	7	concerning	concern	VBG
cord-006229-7yoilsho	4936	8	the	the	DT
cord-006229-7yoilsho	4936	9	feeding	feeding	NN
cord-006229-7yoilsho	4936	10	time	time	NN
cord-006229-7yoilsho	4936	11	in	in	IN
cord-006229-7yoilsho	4936	12	some	some	DT
cord-006229-7yoilsho	4936	13	studies	study	NNS
cord-006229-7yoilsho	4936	14	,	,	,
cord-006229-7yoilsho	4936	15	all	all	DT
cord-006229-7yoilsho	4936	16	rats	rat	NNS
cord-006229-7yoilsho	4936	17	should	should	MD
cord-006229-7yoilsho	4936	18	be	be	VB
cord-006229-7yoilsho	4936	19	allowed	allow	VBN
cord-006229-7yoilsho	4936	20	to	to	TO
cord-006229-7yoilsho	4936	21	continue	continue	VB
cord-006229-7yoilsho	4936	22	to	to	TO
cord-006229-7yoilsho	4936	23	feed	feed	VB
cord-006229-7yoilsho	4936	24	on	on	IN
cord-006229-7yoilsho	4936	25	their	-PRON-	PRP$
cord-006229-7yoilsho	4936	26	respective	respective	JJ
cord-006229-7yoilsho	4936	27	diets	diet	NNS
cord-006229-7yoilsho	4936	28	until	until	IN
cord-006229-7yoilsho	4936	29	the	the	DT
cord-006229-7yoilsho	4936	30	end	end	NN
cord-006229-7yoilsho	4936	31	of	of	IN
cord-006229-7yoilsho	4936	32	the	the	DT
cord-006229-7yoilsho	4936	33	study	study	NN
cord-006229-7yoilsho	4936	34	.	.	.
cord-006229-7yoilsho	4937	1	But	but	CC
cord-006229-7yoilsho	4937	2	what	what	WP
cord-006229-7yoilsho	4937	3	would	would	MD
cord-006229-7yoilsho	4937	4	happen	happen	VB
cord-006229-7yoilsho	4937	5	if	if	IN
cord-006229-7yoilsho	4937	6	the	the	DT
cord-006229-7yoilsho	4937	7	HFD	HFD	NNP
cord-006229-7yoilsho	4937	8	was	be	VBD
cord-006229-7yoilsho	4937	9	switched	switch	VBN
cord-006229-7yoilsho	4937	10	to	to	IN
cord-006229-7yoilsho	4937	11	normal	normal	JJ
cord-006229-7yoilsho	4937	12	pellet	pellet	NN
cord-006229-7yoilsho	4937	13	diet	diet	NN
cord-006229-7yoilsho	4937	14	in	in	IN
cord-006229-7yoilsho	4937	15	these	these	DT
cord-006229-7yoilsho	4937	16	diabetic	diabetic	JJ
cord-006229-7yoilsho	4937	17	rats	rat	NNS
cord-006229-7yoilsho	4937	18	?	?	.
cord-006229-7yoilsho	4938	1	In	in	IN
cord-006229-7yoilsho	4938	2	our	-PRON-	PRP$
cord-006229-7yoilsho	4938	3	experience	experience	NN
cord-006229-7yoilsho	4938	4	,	,	,
cord-006229-7yoilsho	4938	5	the	the	DT
cord-006229-7yoilsho	4938	6	feeding	feeding	NN
cord-006229-7yoilsho	4938	7	of	of	IN
cord-006229-7yoilsho	4938	8	NPD	NPD	NNP
cord-006229-7yoilsho	4938	9	for	for	IN
cord-006229-7yoilsho	4938	10	4	4	CD
cord-006229-7yoilsho	4938	11	weeks	week	NNS
cord-006229-7yoilsho	4938	12	significantly	significantly	RB
cord-006229-7yoilsho	4938	13	decreased	decrease	VBD
cord-006229-7yoilsho	4938	14	FBG	FBG	NNP
cord-006229-7yoilsho	4938	15	in	in	IN
cord-006229-7yoilsho	4938	16	diabetic	diabetic	JJ
cord-006229-7yoilsho	4938	17	rats	rat	NNS
cord-006229-7yoilsho	4938	18	compared	compare	VBN
cord-006229-7yoilsho	4938	19	to	to	IN
cord-006229-7yoilsho	4938	20	HFD	HFD	NNP
cord-006229-7yoilsho	4938	21	-	-	HYPH
cord-006229-7yoilsho	4938	22	fed	feed	VBN
cord-006229-7yoilsho	4938	23	diabetic	diabetic	JJ
cord-006229-7yoilsho	4938	24	rats	rat	NNS
cord-006229-7yoilsho	4938	25	(	(	-LRB-
cord-006229-7yoilsho	4938	26	234.40	234.40	CD
cord-006229-7yoilsho	4938	27	±	±	CD
cord-006229-7yoilsho	4938	28	42.71	42.71	CD
cord-006229-7yoilsho	4938	29	mg	mg	NNP
cord-006229-7yoilsho	4938	30	/	/	SYM
cord-006229-7yoilsho	4938	31	dl	dl	NN
cord-006229-7yoilsho	4938	32	vs.	vs.	NN
cord-006229-7yoilsho	4938	33	464.00	464.00	CD
cord-006229-7yoilsho	4938	34	±	±	CD
cord-006229-7yoilsho	4938	35	23.88	23.88	CD
cord-006229-7yoilsho	4939	1	mg	mg	NNP
cord-006229-7yoilsho	4939	2	/	/	SYM
cord-006229-7yoilsho	4939	3	dl	dl	NNP
cord-006229-7yoilsho	4939	4	,	,	,
cord-006229-7yoilsho	4939	5	p	p	NN
cord-006229-7yoilsho	4939	6	<	<	XX
cord-006229-7yoilsho	4939	7	0.05	0.05	CD
cord-006229-7yoilsho	4939	8	)	)	-RRB-
cord-006229-7yoilsho	4939	9	.	.	.
cord-006229-7yoilsho	4940	1	Although	although	IN
cord-006229-7yoilsho	4940	2	diet	diet	NN
cord-006229-7yoilsho	4940	3	regulation	regulation	NN
cord-006229-7yoilsho	4940	4	could	could	MD
cord-006229-7yoilsho	4940	5	not	not	RB
cord-006229-7yoilsho	4940	6	restore	restore	VB
cord-006229-7yoilsho	4940	7	normal	normal	JJ
cord-006229-7yoilsho	4940	8	blood	blood	NN
cord-006229-7yoilsho	4940	9	glucose	glucose	NN
cord-006229-7yoilsho	4940	10	,	,	,
cord-006229-7yoilsho	4940	11	such	such	PDT
cord-006229-7yoilsho	4940	12	a	a	DT
cord-006229-7yoilsho	4940	13	decrease	decrease	NN
cord-006229-7yoilsho	4940	14	was	be	VBD
cord-006229-7yoilsho	4940	15	unexpected	unexpected	JJ
cord-006229-7yoilsho	4940	16	.	.	.
cord-006229-7yoilsho	4941	1	In	in	IN
cord-006229-7yoilsho	4941	2	addition	addition	NN
cord-006229-7yoilsho	4941	3	,	,	,
cord-006229-7yoilsho	4941	4	the	the	DT
cord-006229-7yoilsho	4941	5	body	body	NN
cord-006229-7yoilsho	4941	6	weights	weight	NNS
cord-006229-7yoilsho	4941	7	of	of	IN
cord-006229-7yoilsho	4941	8	the	the	DT
cord-006229-7yoilsho	4941	9	NPD	NPD	NNP
cord-006229-7yoilsho	4941	10	-	-	HYPH
cord-006229-7yoilsho	4941	11	fed	feed	VBN
cord-006229-7yoilsho	4941	12	diabetic	diabetic	JJ
cord-006229-7yoilsho	4941	13	rats	rat	NNS
cord-006229-7yoilsho	4941	14	were	be	VBD
cord-006229-7yoilsho	4941	15	significantly	significantly	RB
cord-006229-7yoilsho	4941	16	lower	low	JJR
cord-006229-7yoilsho	4941	17	than	than	IN
cord-006229-7yoilsho	4941	18	the	the	DT
cord-006229-7yoilsho	4941	19	body	body	NN
cord-006229-7yoilsho	4941	20	weights	weight	NNS
cord-006229-7yoilsho	4941	21	of	of	IN
cord-006229-7yoilsho	4941	22	the	the	DT
cord-006229-7yoilsho	4941	23	HFD	HFD	NNP
cord-006229-7yoilsho	4941	24	-	-	HYPH
cord-006229-7yoilsho	4941	25	fed	feed	VBN
cord-006229-7yoilsho	4941	26	diabetic	diabetic	JJ
cord-006229-7yoilsho	4941	27	rats	rat	NNS
cord-006229-7yoilsho	4941	28	(	(	-LRB-
cord-006229-7yoilsho	4941	29	249	249	CD
cord-006229-7yoilsho	4941	30	±6.00	±6.00	JJ
cord-006229-7yoilsho	4941	31	gvs	gvs	NNP
cord-006229-7yoilsho	4941	32	.	.	.
cord-006229-7yoilsho	4942	1	288.00	288.00	CD
cord-006229-7yoilsho	4942	2	±4.41	±4.41	NNP
cord-006229-7yoilsho	4942	3	g	g	NN
cord-006229-7yoilsho	4942	4	,	,	,
cord-006229-7yoilsho	4942	5	p	p	NN
cord-006229-7yoilsho	4942	6	<	<	XX
cord-006229-7yoilsho	4942	7	0.05	0.05	CD
cord-006229-7yoilsho	4942	8	)	)	-RRB-
cord-006229-7yoilsho	4942	9	.	.	.
cord-006229-7yoilsho	4943	1	There	there	EX
cord-006229-7yoilsho	4943	2	was	be	VBD
cord-006229-7yoilsho	4943	3	no	no	DT
cord-006229-7yoilsho	4943	4	significant	significant	JJ
cord-006229-7yoilsho	4943	5	difference	difference	NN
cord-006229-7yoilsho	4943	6	in	in	IN
cord-006229-7yoilsho	4943	7	body	body	NN
cord-006229-7yoilsho	4943	8	weight	weight	NN
cord-006229-7yoilsho	4943	9	between	between	IN
cord-006229-7yoilsho	4943	10	nondiabetic	nondiabetic	JJ
cord-006229-7yoilsho	4943	11	control	control	NN
cord-006229-7yoilsho	4943	12	rats	rat	NNS
cord-006229-7yoilsho	4943	13	and	and	CC
cord-006229-7yoilsho	4943	14	diabetic	diabetic	JJ
cord-006229-7yoilsho	4943	15	rats	rat	NNS
cord-006229-7yoilsho	4943	16	fed	feed	VBD
cord-006229-7yoilsho	4943	17	NPD	NPD	NNP
cord-006229-7yoilsho	4943	18	for	for	IN
cord-006229-7yoilsho	4943	19	4	4	CD
cord-006229-7yoilsho	4943	20	weeks	week	NNS
cord-006229-7yoilsho	4943	21	.	.	.
cord-006229-7yoilsho	4944	1	Further	further	JJ
cord-006229-7yoilsho	4944	2	details	detail	NNS
cord-006229-7yoilsho	4944	3	can	can	MD
cord-006229-7yoilsho	4944	4	be	be	VB
cord-006229-7yoilsho	4944	5	found	find	VBN
cord-006229-7yoilsho	4944	6	in	in	IN
cord-006229-7yoilsho	4944	7	Table	Table	NNP
cord-006229-7yoilsho	4944	8	1	1	CD
cord-006229-7yoilsho	4944	9	.	.	.
cord-006229-7yoilsho	4945	1	Diet	diet	NN
cord-006229-7yoilsho	4945	2	regulation	regulation	NN
cord-006229-7yoilsho	4945	3	and	and	CC
cord-006229-7yoilsho	4945	4	weight	weight	NN
cord-006229-7yoilsho	4945	5	loss	loss	NN
cord-006229-7yoilsho	4945	6	may	may	MD
cord-006229-7yoilsho	4945	7	prevent	prevent	VB
cord-006229-7yoilsho	4945	8	,	,	,
cord-006229-7yoilsho	4945	9	control	control	VB
cord-006229-7yoilsho	4945	10	and	and	CC
cord-006229-7yoilsho	4945	11	reverse	reverse	VB
cord-006229-7yoilsho	4945	12	diabetes	diabetes	NN
cord-006229-7yoilsho	4945	13	.	.	.
cord-006229-7yoilsho	4946	1	However	however	RB
cord-006229-7yoilsho	4946	2	,	,	,
cord-006229-7yoilsho	4946	3	at	at	IN
cord-006229-7yoilsho	4946	4	later	later	JJ
cord-006229-7yoilsho	4946	5	stages	stage	NNS
cord-006229-7yoilsho	4946	6	of	of	IN
cord-006229-7yoilsho	4946	7	the	the	DT
cord-006229-7yoilsho	4946	8	disease	disease	NN
cord-006229-7yoilsho	4946	9	,	,	,
cord-006229-7yoilsho	4946	10	it	-PRON-	PRP
cord-006229-7yoilsho	4946	11	is	be	VBZ
cord-006229-7yoilsho	4946	12	difficult	difficult	JJ
cord-006229-7yoilsho	4946	13	to	to	TO
cord-006229-7yoilsho	4946	14	improve	improve	VB
cord-006229-7yoilsho	4946	15	blood	blood	NN
cord-006229-7yoilsho	4946	16	glucose	glucose	NN
cord-006229-7yoilsho	4946	17	control	control	NN
cord-006229-7yoilsho	4946	18	without	without	IN
cord-006229-7yoilsho	4946	19	medication	medication	NN
cord-006229-7yoilsho	4946	20	,	,	,
cord-006229-7yoilsho	4946	21	because	because	IN
cord-006229-7yoilsho	4946	22	the	the	DT
cord-006229-7yoilsho	4946	23	disease	disease	NN
cord-006229-7yoilsho	4946	24	progresses	progress	VBZ
cord-006229-7yoilsho	4946	25	from	from	IN
cord-006229-7yoilsho	4946	26	insulin	insulin	NN
cord-006229-7yoilsho	4946	27	resistance	resistance	NN
cord-006229-7yoilsho	4946	28	to	to	IN
cord-006229-7yoilsho	4946	29	insulin	insulin	NN
cord-006229-7yoilsho	4946	30	deficiency	deficiency	NN
cord-006229-7yoilsho	4946	31	(	(	-LRB-
cord-006229-7yoilsho	4946	32	3	3	CD
cord-006229-7yoilsho	4946	33	)	)	-RRB-
cord-006229-7yoilsho	4946	34	.	.	.
cord-006229-7yoilsho	4947	1	According	accord	VBG
cord-006229-7yoilsho	4947	2	to	to	IN
cord-006229-7yoilsho	4947	3	some	some	DT
cord-006229-7yoilsho	4947	4	diabetes	diabetes	NN
cord-006229-7yoilsho	4947	5	researchers	researcher	NNS
cord-006229-7yoilsho	4947	6	,	,	,
cord-006229-7yoilsho	4947	7	the	the	DT
cord-006229-7yoilsho	4947	8	amount	amount	NN
cord-006229-7yoilsho	4947	9	of	of	IN
cord-006229-7yoilsho	4947	10	residual	residual	JJ
cord-006229-7yoilsho	4947	11	functional	functional	JJ
cord-006229-7yoilsho	4947	12	betacells	betacell	NNS
cord-006229-7yoilsho	4947	13	mass	mass	NN
cord-006229-7yoilsho	4947	14	is	be	VBZ
cord-006229-7yoilsho	4947	15	an	an	DT
cord-006229-7yoilsho	4947	16	important	important	JJ
cord-006229-7yoilsho	4947	17	issue	issue	NN
cord-006229-7yoilsho	4947	18	,	,	,
cord-006229-7yoilsho	4947	19	and	and	CC
cord-006229-7yoilsho	4947	20	another	another	DT
cord-006229-7yoilsho	4947	21	important	important	JJ
cord-006229-7yoilsho	4947	22	question	question	NN
cord-006229-7yoilsho	4947	23	is	be	VBZ
cord-006229-7yoilsho	4947	24	whether	whether	IN
cord-006229-7yoilsho	4947	25	HFD	HFD	NNP
cord-006229-7yoilsho	4947	26	/	/	SYM
cord-006229-7yoilsho	4947	27	STZ	STZ	NNP
cord-006229-7yoilsho	4947	28	rat	rat	NN
cord-006229-7yoilsho	4947	29	mimics	mimic	VBZ
cord-006229-7yoilsho	4947	30	an	an	DT
cord-006229-7yoilsho	4947	31	early	early	JJ
cord-006229-7yoilsho	4947	32	or	or	CC
cord-006229-7yoilsho	4947	33	late	late	JJ
cord-006229-7yoilsho	4947	34	stage	stage	NN
cord-006229-7yoilsho	4947	35	of	of	IN
cord-006229-7yoilsho	4947	36	type	type	NN
cord-006229-7yoilsho	4947	37	2	2	CD
cord-006229-7yoilsho	4947	38	diabetes	diabetes	NN
cord-006229-7yoilsho	4947	39	(	(	-LRB-
cord-006229-7yoilsho	4947	40	4	4	CD
cord-006229-7yoilsho	4947	41	)	)	-RRB-
cord-006229-7yoilsho	4947	42	.	.	.
cord-006229-7yoilsho	4948	1	These	these	DT
cord-006229-7yoilsho	4948	2	preliminary	preliminary	JJ
cord-006229-7yoilsho	4948	3	findings	finding	NNS
cord-006229-7yoilsho	4948	4	suggest	suggest	VBP
cord-006229-7yoilsho	4948	5	the	the	DT
cord-006229-7yoilsho	4948	6	possibility	possibility	NN
cord-006229-7yoilsho	4948	7	that	that	IN
cord-006229-7yoilsho	4948	8	HFD	HFD	NNP
cord-006229-7yoilsho	4948	9	/	/	SYM
cord-006229-7yoilsho	4948	10	STZ	STZ	NNP
cord-006229-7yoilsho	4948	11	rat	rat	NN
cord-006229-7yoilsho	4948	12	model	model	NN
cord-006229-7yoilsho	4948	13	may	may	MD
cord-006229-7yoilsho	4948	14	simulate	simulate	VB
cord-006229-7yoilsho	4948	15	the	the	DT
cord-006229-7yoilsho	4948	16	characteristics	characteristic	NNS
cord-006229-7yoilsho	4948	17	of	of	IN
cord-006229-7yoilsho	4948	18	early	early	JJ
cord-006229-7yoilsho	4948	19	stage	stage	NN
cord-006229-7yoilsho	4948	20	more	more	JJR
cord-006229-7yoilsho	4948	21	than	than	IN
cord-006229-7yoilsho	4948	22	the	the	DT
cord-006229-7yoilsho	4948	23	final	final	JJ
cord-006229-7yoilsho	4948	24	stage	stage	NN
cord-006229-7yoilsho	4948	25	of	of	IN
cord-006229-7yoilsho	4948	26	type	type	NN
cord-006229-7yoilsho	4948	27	2	2	CD
cord-006229-7yoilsho	4948	28	diabetes	diabete	NNS
cord-006229-7yoilsho	4948	29	,	,	,
cord-006229-7yoilsho	4948	30	and	and	CC
cord-006229-7yoilsho	4948	31	hyperglicemia	hyperglicemia	NN
cord-006229-7yoilsho	4948	32	in	in	IN
cord-006229-7yoilsho	4948	33	the	the	DT
cord-006229-7yoilsho	4948	34	experimental	experimental	JJ
cord-006229-7yoilsho	4948	35	model	model	NN
cord-006229-7yoilsho	4948	36	can	can	MD
cord-006229-7yoilsho	4948	37	partially	partially	RB
cord-006229-7yoilsho	4948	38	reverse	reverse	VB
cord-006229-7yoilsho	4948	39	with	with	IN
cord-006229-7yoilsho	4948	40	diet	diet	NN
cord-006229-7yoilsho	4948	41	regulation	regulation	NN
cord-006229-7yoilsho	4948	42	.	.	.
cord-006229-7yoilsho	4949	1	References	reference	NNS
cord-006229-7yoilsho	4949	2	:	:	:
cord-006229-7yoilsho	4949	3	1	1	CD
cord-006229-7yoilsho	4949	4	.	.	.
cord-006229-7yoilsho	4950	1	Srinivasan	Srinivasan	NNP
cord-006229-7yoilsho	4950	2	,	,	,
cord-006229-7yoilsho	4950	3	K.	K.	NNP
cord-006229-7yoilsho	4950	4	,	,	,
cord-006229-7yoilsho	4950	5	Viswanad	Viswanad	NNP
cord-006229-7yoilsho	4950	6	,	,	,
cord-006229-7yoilsho	4950	7	B.	B.	NNP
cord-006229-7yoilsho	4950	8	,	,	,
cord-006229-7yoilsho	4950	9	Asrat	Asrat	NNP
cord-006229-7yoilsho	4950	10	,	,	,
cord-006229-7yoilsho	4950	11	L.	L.	NNP
cord-006229-7yoilsho	4950	12	,	,	,
cord-006229-7yoilsho	4950	13	Kaul	Kaul	NNP
cord-006229-7yoilsho	4950	14	,	,	,
cord-006229-7yoilsho	4950	15	C.	C.	NNP
cord-006229-7yoilsho	4950	16	L.	L.	NNP
cord-006229-7yoilsho	4950	17	,	,	,
cord-006229-7yoilsho	4950	18	Ramarao	Ramarao	NNP
cord-006229-7yoilsho	4950	19	,	,	,
cord-006229-7yoilsho	4950	20	P.	P.	NNP
cord-006229-7yoilsho	4950	21	(	(	-LRB-
cord-006229-7yoilsho	4950	22	2005	2005	CD
cord-006229-7yoilsho	4950	23	)	)	-RRB-
cord-006229-7yoilsho	4950	24	.	.	.
cord-006229-7yoilsho	4951	1	Combination	combination	NN
cord-006229-7yoilsho	4951	2	of	of	IN
cord-006229-7yoilsho	4951	3	high	high	JJ
cord-006229-7yoilsho	4951	4	-	-	HYPH
cord-006229-7yoilsho	4951	5	fat	fat	NN
cord-006229-7yoilsho	4951	6	diet	diet	NN
cord-006229-7yoilsho	4951	7	-	-	HYPH
cord-006229-7yoilsho	4951	8	fed	feed	VBN
cord-006229-7yoilsho	4951	9	and	and	CC
cord-006229-7yoilsho	4951	10	low	low	JJ
cord-006229-7yoilsho	4951	11	-	-	HYPH
cord-006229-7yoilsho	4951	12	dose	dose	NN
cord-006229-7yoilsho	4951	13	streptozotocin	streptozotocin	NNS
cord-006229-7yoilsho	4951	14	-	-	HYPH
cord-006229-7yoilsho	4951	15	treated	treat	VBN
cord-006229-7yoilsho	4951	16	rat	rat	NN
cord-006229-7yoilsho	4951	17	:	:	:
cord-006229-7yoilsho	4951	18	a	a	DT
cord-006229-7yoilsho	4951	19	model	model	NN
cord-006229-7yoilsho	4951	20	for	for	IN
cord-006229-7yoilsho	4951	21	type	type	NN
cord-006229-7yoilsho	4951	22	2	2	CD
cord-006229-7yoilsho	4951	23	diabetes	diabete	NNS
cord-006229-7yoilsho	4951	24	and	and	CC
cord-006229-7yoilsho	4951	25	pharmacological	pharmacological	JJ
cord-006229-7yoilsho	4951	26	screening	screening	NN
cord-006229-7yoilsho	4951	27	.	.	.
cord-006229-7yoilsho	4952	1	Pharmacol	Pharmacol	NNP
cord-006229-7yoilsho	4952	2	Res	Res	NNP
cord-006229-7yoilsho	4952	3	52	52	CD
cord-006229-7yoilsho	4952	4	(	(	-LRB-
cord-006229-7yoilsho	4952	5	4	4	CD
cord-006229-7yoilsho	4952	6	)	)	-RRB-
cord-006229-7yoilsho	4952	7	:	:	:
cord-006229-7yoilsho	4952	8	313	313	CD
cord-006229-7yoilsho	4952	9	-	-	SYM
cord-006229-7yoilsho	4952	10	320	320	CD
cord-006229-7yoilsho	4952	11	.	.	.
cord-006229-7yoilsho	4952	12	2	2	CD
cord-006229-7yoilsho	4952	13	.	.	.
cord-006229-7yoilsho	4953	1	Oztürk	Oztürk	NNP
cord-006229-7yoilsho	4953	2	Z	Z	NNP
cord-006229-7yoilsho	4953	3	,	,	,
cord-006229-7yoilsho	4953	4	Gurpinar	Gurpinar	NNP
cord-006229-7yoilsho	4953	5	T	T	NNP
cord-006229-7yoilsho	4953	6	,	,	,
cord-006229-7yoilsho	4953	7	Vural	Vural	NNP
cord-006229-7yoilsho	4953	8	K	K	NNP
cord-006229-7yoilsho	4953	9	,	,	,
cord-006229-7yoilsho	4953	10	Boyacıoglu	Boyacıoglu	NNP
cord-006229-7yoilsho	4953	11	S	S	NNP
cord-006229-7yoilsho	4953	12	,	,	,
cord-006229-7yoilsho	4953	13	Korkmaz	Korkmaz	NNP
cord-006229-7yoilsho	4953	14	M	M	NNP
cord-006229-7yoilsho	4953	15	,	,	,
cord-006229-7yoilsho	4953	16	Var	Var	NNP
cord-006229-7yoilsho	4953	17	A.	a.	NN
cord-006229-7yoilsho	4953	18	(	(	-LRB-
cord-006229-7yoilsho	4953	19	2015	2015	CD
cord-006229-7yoilsho	4953	20	)	)	-RRB-
cord-006229-7yoilsho	4953	21	.	.	.
cord-006229-7yoilsho	4954	1	Effects	effect	NNS
cord-006229-7yoilsho	4954	2	of	of	IN
cord-006229-7yoilsho	4954	3	selenium	selenium	NN
cord-006229-7yoilsho	4954	4	on	on	IN
cord-006229-7yoilsho	4954	5	endothelial	endothelial	JJ
cord-006229-7yoilsho	4954	6	dysfunction	dysfunction	NN
cord-006229-7yoilsho	4954	7	and	and	CC
cord-006229-7yoilsho	4954	8	metabolic	metabolic	JJ
cord-006229-7yoilsho	4954	9	profile	profile	NN
cord-006229-7yoilsho	4954	10	in	in	IN
cord-006229-7yoilsho	4954	11	low	low	JJ
cord-006229-7yoilsho	4954	12	dose	dose	NN
cord-006229-7yoilsho	4954	13	streptozotocin	streptozotocin	NNS
cord-006229-7yoilsho	4954	14	induced	induce	VBN
cord-006229-7yoilsho	4954	15	diabetic	diabetic	JJ
cord-006229-7yoilsho	4954	16	rats	rat	NNS
cord-006229-7yoilsho	4954	17	fed	feed	VBD
cord-006229-7yoilsho	4954	18	a	a	DT
cord-006229-7yoilsho	4954	19	high	high	JJ
cord-006229-7yoilsho	4954	20	fat	fat	NN
cord-006229-7yoilsho	4954	21	diet	diet	NN
cord-006229-7yoilsho	4954	22	.	.	.
cord-006229-7yoilsho	4955	1	Biotech	Biotech	NNP
cord-006229-7yoilsho	4955	2	Histochem	Histochem	NNP
cord-006229-7yoilsho	4955	3	90	90	CD
cord-006229-7yoilsho	4955	4	(	(	-LRB-
cord-006229-7yoilsho	4955	5	7	7	CD
cord-006229-7yoilsho	4955	6	)	)	-RRB-
cord-006229-7yoilsho	4955	7	:	:	:
cord-006229-7yoilsho	4955	8	506	506	CD
cord-006229-7yoilsho	4955	9	-	-	SYM
cord-006229-7yoilsho	4955	10	515	515	CD
cord-006229-7yoilsho	4955	11	.	.	.
cord-006229-7yoilsho	4956	1	3	3	LS
cord-006229-7yoilsho	4956	2	.	.	.
cord-006229-7yoilsho	4957	1	Franz	Franz	NNP
cord-006229-7yoilsho	4957	2	,	,	,
cord-006229-7yoilsho	4957	3	M.	M.	NNP
cord-006229-7yoilsho	4957	4	J.	J.	NNP
cord-006229-7yoilsho	4957	5	(	(	-LRB-
cord-006229-7yoilsho	4957	6	2007	2007	CD
cord-006229-7yoilsho	4957	7	)	)	-RRB-
cord-006229-7yoilsho	4957	8	.	.	.
cord-006229-7yoilsho	4958	1	The	the	DT
cord-006229-7yoilsho	4958	2	dilemma	dilemma	NN
cord-006229-7yoilsho	4958	3	of	of	IN
cord-006229-7yoilsho	4958	4	weight	weight	NN
cord-006229-7yoilsho	4958	5	loss	loss	NN
cord-006229-7yoilsho	4958	6	in	in	IN
cord-006229-7yoilsho	4958	7	diabetes	diabetes	NN
cord-006229-7yoilsho	4958	8	.	.	.
cord-006229-7yoilsho	4959	1	Diabetes	diabetes	NN
cord-006229-7yoilsho	4959	2	spectr	spectr	NN
cord-006229-7yoilsho	4959	3	20	20	CD
cord-006229-7yoilsho	4959	4	(	(	-LRB-
cord-006229-7yoilsho	4959	5	3	3	CD
cord-006229-7yoilsho	4959	6	)	)	-RRB-
cord-006229-7yoilsho	4960	1	Animal	animal	NN
cord-006229-7yoilsho	4960	2	models	model	NNS
cord-006229-7yoilsho	4960	3	are	be	VBP
cord-006229-7yoilsho	4960	4	pivotal	pivotal	JJ
cord-006229-7yoilsho	4960	5	for	for	IN
cord-006229-7yoilsho	4960	6	studies	study	NNS
cord-006229-7yoilsho	4960	7	of	of	IN
cord-006229-7yoilsho	4960	8	pathogenesis	pathogenesis	NN
cord-006229-7yoilsho	4960	9	and	and	CC
cord-006229-7yoilsho	4960	10	treatment	treatment	NN
cord-006229-7yoilsho	4960	11	of	of	IN
cord-006229-7yoilsho	4960	12	movement	movement	NN
cord-006229-7yoilsho	4960	13	disorders	disorder	NNS
cord-006229-7yoilsho	4960	14	.	.	.
cord-006229-7yoilsho	4961	1	Dystonia	Dystonia	NNP
cord-006229-7yoilsho	4961	2	,	,	,
cord-006229-7yoilsho	4961	3	characterized	characterize	VBN
cord-006229-7yoilsho	4961	4	by	by	IN
cord-006229-7yoilsho	4961	5	sustained	sustained	JJ
cord-006229-7yoilsho	4961	6	or	or	CC
cord-006229-7yoilsho	4961	7	intermittent	intermittent	JJ
cord-006229-7yoilsho	4961	8	muscle	muscle	NN
cord-006229-7yoilsho	4961	9	contractions	contraction	NNS
cord-006229-7yoilsho	4961	10	causing	cause	VBG
cord-006229-7yoilsho	4961	11	twisting	twist	VBG
cord-006229-7yoilsho	4961	12	movements	movement	NNS
cord-006229-7yoilsho	4961	13	/	/	SYM
cord-006229-7yoilsho	4961	14	postures	posture	NNS
cord-006229-7yoilsho	4961	15	,	,	,
cord-006229-7yoilsho	4961	16	is	be	VBZ
cord-006229-7yoilsho	4961	17	regarded	regard	VBN
cord-006229-7yoilsho	4961	18	as	as	IN
cord-006229-7yoilsho	4961	19	a	a	DT
cord-006229-7yoilsho	4961	20	basal	basal	NN
cord-006229-7yoilsho	4961	21	ganglia	ganglion	NNS
cord-006229-7yoilsho	4961	22	disorder	disorder	NN
cord-006229-7yoilsho	4961	23	.	.	.
cord-006229-7yoilsho	4962	1	The	the	DT
cord-006229-7yoilsho	4962	2	pathophysiology	pathophysiology	NN
cord-006229-7yoilsho	4962	3	is	be	VBZ
cord-006229-7yoilsho	4962	4	however	however	RB
cord-006229-7yoilsho	4962	5	poorly	poorly	RB
cord-006229-7yoilsho	4962	6	understood	understand	VBN
cord-006229-7yoilsho	4962	7	.	.	.
cord-006229-7yoilsho	4963	1	In	in	IN
cord-006229-7yoilsho	4963	2	mouse	mouse	NN
cord-006229-7yoilsho	4963	3	models	model	NNS
cord-006229-7yoilsho	4963	4	of	of	IN
cord-006229-7yoilsho	4963	5	DYT1	DYT1	NNP
cord-006229-7yoilsho	4963	6	dystonia	dystonia	NN
cord-006229-7yoilsho	4963	7	,	,	,
cord-006229-7yoilsho	4963	8	which	which	WDT
cord-006229-7yoilsho	4963	9	is	be	VBZ
cord-006229-7yoilsho	4963	10	caused	cause	VBN
cord-006229-7yoilsho	4963	11	by	by	IN
cord-006229-7yoilsho	4963	12	a	a	DT
cord-006229-7yoilsho	4963	13	GAG	gag	NN
cord-006229-7yoilsho	4963	14	deletion	deletion	NN
cord-006229-7yoilsho	4963	15	in	in	IN
cord-006229-7yoilsho	4963	16	TOR1A	tor1a	CD
cord-006229-7yoilsho	4963	17	that	that	WDT
cord-006229-7yoilsho	4963	18	encodes	encode	VBZ
cord-006229-7yoilsho	4963	19	for	for	IN
cord-006229-7yoilsho	4963	20	the	the	DT
cord-006229-7yoilsho	4963	21	protein	protein	NN
cord-006229-7yoilsho	4963	22	torsin	torsin	NNP
cord-006229-7yoilsho	4963	23	A	A	NNP
cord-006229-7yoilsho	4963	24	,	,	,
cord-006229-7yoilsho	4963	25	ex	ex	NN
cord-006229-7yoilsho	4963	26	vivo	vivo	FW
cord-006229-7yoilsho	4963	27	electrophysiological	electrophysiological	JJ
cord-006229-7yoilsho	4963	28	studies	study	NNS
cord-006229-7yoilsho	4963	29	have	have	VBP
cord-006229-7yoilsho	4963	30	shown	show	VBN
cord-006229-7yoilsho	4963	31	an	an	DT
cord-006229-7yoilsho	4963	32	abnormal	abnormal	JJ
cord-006229-7yoilsho	4963	33	D2	d2	NN
cord-006229-7yoilsho	4963	34	receptor	receptor	NN
cord-006229-7yoilsho	4963	35	mediated	mediate	VBN
cord-006229-7yoilsho	4963	36	release	release	NN
cord-006229-7yoilsho	4963	37	of	of	IN
cord-006229-7yoilsho	4963	38	acetylcholine	acetylcholine	NN
cord-006229-7yoilsho	4963	39	from	from	IN
cord-006229-7yoilsho	4963	40	striatal	striatal	JJ
cord-006229-7yoilsho	4963	41	interneurons	interneuron	NNS
cord-006229-7yoilsho	4963	42	.	.	.
cord-006229-7yoilsho	4964	1	In	in	IN
cord-006229-7yoilsho	4964	2	these	these	DT
cord-006229-7yoilsho	4964	3	models	model	NNS
cord-006229-7yoilsho	4964	4	,	,	,
cord-006229-7yoilsho	4964	5	which	which	WDT
cord-006229-7yoilsho	4964	6	do	do	VBP
cord-006229-7yoilsho	4964	7	not	not	RB
cord-006229-7yoilsho	4964	8	exhibit	exhibit	VB
cord-006229-7yoilsho	4964	9	a	a	DT
cord-006229-7yoilsho	4964	10	dystonic	dystonic	JJ
cord-006229-7yoilsho	4964	11	phenotype	phenotype	NN
cord-006229-7yoilsho	4964	12	,	,	,
cord-006229-7yoilsho	4964	13	the	the	DT
cord-006229-7yoilsho	4964	14	functional	functional	JJ
cord-006229-7yoilsho	4964	15	relevance	relevance	NN
cord-006229-7yoilsho	4964	16	of	of	IN
cord-006229-7yoilsho	4964	17	the	the	DT
cord-006229-7yoilsho	4964	18	increased	increase	VBN
cord-006229-7yoilsho	4964	19	D2	d2	NN
cord-006229-7yoilsho	4964	20	receptor	receptor	NN
cord-006229-7yoilsho	4964	21	mediated	mediate	VBD
cord-006229-7yoilsho	4964	22	acetylcholine	acetylcholine	NN
cord-006229-7yoilsho	4964	23	release	release	NN
cord-006229-7yoilsho	4964	24	has	have	VBZ
cord-006229-7yoilsho	4964	25	not	not	RB
cord-006229-7yoilsho	4964	26	been	be	VBN
cord-006229-7yoilsho	4964	27	examined	examine	VBN
cord-006229-7yoilsho	4964	28	yet	yet	RB
cord-006229-7yoilsho	4964	29	.	.	.
cord-006229-7yoilsho	4965	1	The	the	DT
cord-006229-7yoilsho	4965	2	aim	aim	NN
cord-006229-7yoilsho	4965	3	of	of	IN
cord-006229-7yoilsho	4965	4	present	present	JJ
cord-006229-7yoilsho	4965	5	study	study	NN
cord-006229-7yoilsho	4965	6	was	be	VBD
cord-006229-7yoilsho	4965	7	to	to	IN
cord-006229-7yoilsho	4965	8	(	(	-LRB-
cord-006229-7yoilsho	4965	9	1	1	LS
cord-006229-7yoilsho	4965	10	)	)	-RRB-
cord-006229-7yoilsho	4965	11	generate	generate	VB
cord-006229-7yoilsho	4965	12	more	more	RBR
cord-006229-7yoilsho	4965	13	powerful	powerful	JJ
cord-006229-7yoilsho	4965	14	tests	test	NNS
cord-006229-7yoilsho	4965	15	to	to	TO
cord-006229-7yoilsho	4965	16	detect	detect	VB
cord-006229-7yoilsho	4965	17	behavioural	behavioural	JJ
cord-006229-7yoilsho	4965	18	alterations	alteration	NNS
cord-006229-7yoilsho	4965	19	in	in	IN
cord-006229-7yoilsho	4965	20	the	the	DT
cord-006229-7yoilsho	4965	21	DYT1	DYT1	NNP
cord-006229-7yoilsho	4965	22	knock	knock	VB
cord-006229-7yoilsho	4965	23	-	-	HYPH
cord-006229-7yoilsho	4965	24	in	in	RP
cord-006229-7yoilsho	4965	25	mouse	mouse	NN
cord-006229-7yoilsho	4965	26	and	and	CC
cord-006229-7yoilsho	4965	27	to	to	IN
cord-006229-7yoilsho	4965	28	(	(	-LRB-
cord-006229-7yoilsho	4965	29	2	2	LS
cord-006229-7yoilsho	4965	30	)	)	-RRB-
cord-006229-7yoilsho	4965	31	examine	examine	VB
cord-006229-7yoilsho	4965	32	the	the	DT
cord-006229-7yoilsho	4965	33	behavioral	behavioral	JJ
cord-006229-7yoilsho	4965	34	effects	effect	NNS
cord-006229-7yoilsho	4965	35	of	of	IN
cord-006229-7yoilsho	4965	36	the	the	DT
cord-006229-7yoilsho	4965	37	D2	D2	NNP
cord-006229-7yoilsho	4965	38	receptor	receptor	NN
cord-006229-7yoilsho	4965	39	agonist	agonist	NN
cord-006229-7yoilsho	4965	40	quinpirole	quinpirole	NN
cord-006229-7yoilsho	4965	41	.	.	.
cord-006229-7yoilsho	4966	1	For	for	IN
cord-006229-7yoilsho	4966	2	this	this	DT
cord-006229-7yoilsho	4966	3	purpose	purpose	NN
cord-006229-7yoilsho	4966	4	,	,	,
cord-006229-7yoilsho	4966	5	a	a	DT
cord-006229-7yoilsho	4966	6	sequence	sequence	NN
cord-006229-7yoilsho	4966	7	of	of	IN
cord-006229-7yoilsho	4966	8	cognitive	cognitive	JJ
cord-006229-7yoilsho	4966	9	,	,	,
cord-006229-7yoilsho	4966	10	motoric	motoric	JJ
cord-006229-7yoilsho	4966	11	and	and	CC
cord-006229-7yoilsho	4966	12	sensorimotor	sensorimotor	JJ
cord-006229-7yoilsho	4966	13	tests	test	NNS
cord-006229-7yoilsho	4966	14	were	be	VBD
cord-006229-7yoilsho	4966	15	performed	perform	VBN
cord-006229-7yoilsho	4966	16	in	in	IN
cord-006229-7yoilsho	4966	17	this	this	DT
cord-006229-7yoilsho	4966	18	mouse	mouse	NN
cord-006229-7yoilsho	4966	19	model	model	NN
cord-006229-7yoilsho	4966	20	.	.	.
cord-006229-7yoilsho	4967	1	Only	only	RB
cord-006229-7yoilsho	4967	2	the	the	DT
cord-006229-7yoilsho	4967	3	adhesive	adhesive	JJ
cord-006229-7yoilsho	4967	4	removal	removal	NN
cord-006229-7yoilsho	4967	5	test	test	NN
cord-006229-7yoilsho	4967	6	that	that	WDT
cord-006229-7yoilsho	4967	7	explores	explore	VBZ
cord-006229-7yoilsho	4967	8	sensorimotor	sensorimotor	JJ
cord-006229-7yoilsho	4967	9	connectivity	connectivity	NN
cord-006229-7yoilsho	4967	10	revealed	reveal	VBD
cord-006229-7yoilsho	4967	11	significant	significant	JJ
cord-006229-7yoilsho	4967	12	impairments	impairment	NNS
cord-006229-7yoilsho	4967	13	in	in	IN
cord-006229-7yoilsho	4967	14	the	the	DT
cord-006229-7yoilsho	4967	15	DYT1	DYT1	NNP
cord-006229-7yoilsho	4967	16	knock	knock	VB
cord-006229-7yoilsho	4967	17	-	-	HYPH
cord-006229-7yoilsho	4967	18	in	in	RP
cord-006229-7yoilsho	4967	19	mice	mouse	NNS
cord-006229-7yoilsho	4967	20	compared	compare	VBN
cord-006229-7yoilsho	4967	21	to	to	IN
cord-006229-7yoilsho	4967	22	controls	control	NNS
cord-006229-7yoilsho	4967	23	.	.	.
cord-006229-7yoilsho	4968	1	To	to	TO
cord-006229-7yoilsho	4968	2	induce	induce	VB
cord-006229-7yoilsho	4968	3	a	a	DT
cord-006229-7yoilsho	4968	4	more	more	RBR
cord-006229-7yoilsho	4968	5	characteristic	characteristic	JJ
cord-006229-7yoilsho	4968	6	and	and	CC
cord-006229-7yoilsho	4968	7	stronger	strong	JJR
cord-006229-7yoilsho	4968	8	phenotype	phenotype	NN
cord-006229-7yoilsho	4968	9	,	,	,
cord-006229-7yoilsho	4968	10	the	the	DT
cord-006229-7yoilsho	4968	11	"	"	``
cord-006229-7yoilsho	4968	12	rotating	rotate	VBG
cord-006229-7yoilsho	4968	13	beam	beam	NN
cord-006229-7yoilsho	4968	14	test	test	NN
cord-006229-7yoilsho	4968	15	"	"	''
cord-006229-7yoilsho	4968	16	was	be	VBD
cord-006229-7yoilsho	4968	17	developed	develop	VBN
cord-006229-7yoilsho	4968	18	.	.	.
cord-006229-7yoilsho	4969	1	This	this	DT
cord-006229-7yoilsho	4969	2	motoric	motoric	JJ
cord-006229-7yoilsho	4969	3	test	test	NN
cord-006229-7yoilsho	4969	4	measures	measure	NNS
cord-006229-7yoilsho	4969	5	motor	motor	NN
cord-006229-7yoilsho	4969	6	coordination	coordination	NN
cord-006229-7yoilsho	4969	7	and	and	CC
cord-006229-7yoilsho	4969	8	balance	balance	NN
cord-006229-7yoilsho	4969	9	.	.	.
cord-006229-7yoilsho	4970	1	Interestingly	interestingly	RB
cord-006229-7yoilsho	4970	2	,	,	,
cord-006229-7yoilsho	4970	3	DYT1	DYT1	NNP
cord-006229-7yoilsho	4970	4	knock	knock	VB
cord-006229-7yoilsho	4970	5	-	-	HYPH
cord-006229-7yoilsho	4970	6	in	in	RP
cord-006229-7yoilsho	4970	7	mice	mouse	NNS
cord-006229-7yoilsho	4970	8	showed	show	VBD
cord-006229-7yoilsho	4970	9	significant	significant	JJ
cord-006229-7yoilsho	4970	10	motor	motor	NN
cord-006229-7yoilsho	4970	11	deficits	deficit	NNS
cord-006229-7yoilsho	4970	12	in	in	IN
cord-006229-7yoilsho	4970	13	the	the	DT
cord-006229-7yoilsho	4970	14	rotating	rotate	VBG
cord-006229-7yoilsho	4970	15	beam	beam	NN
cord-006229-7yoilsho	4970	16	test	test	NN
cord-006229-7yoilsho	4970	17	.	.	.
cord-006229-7yoilsho	4971	1	Based	base	VBN
cord-006229-7yoilsho	4971	2	on	on	IN
cord-006229-7yoilsho	4971	3	these	these	DT
cord-006229-7yoilsho	4971	4	results	result	NNS
cord-006229-7yoilsho	4971	5	,	,	,
cord-006229-7yoilsho	4971	6	the	the	DT
cord-006229-7yoilsho	4971	7	acute	acute	JJ
cord-006229-7yoilsho	4971	8	effects	effect	NNS
cord-006229-7yoilsho	4971	9	of	of	IN
cord-006229-7yoilsho	4971	10	quinpirole	quinpirole	NN
cord-006229-7yoilsho	4971	11	(	(	-LRB-
cord-006229-7yoilsho	4971	12	0.25	0.25	CD
cord-006229-7yoilsho	4971	13	-1	-1	NNP
cord-006229-7yoilsho	4971	14	mg	mg	NNP
cord-006229-7yoilsho	4971	15	/	/	SYM
cord-006229-7yoilsho	4971	16	kg	kg	NNP
cord-006229-7yoilsho	4971	17	i.p	i.p	NNP
cord-006229-7yoilsho	4971	18	.	.	NNP
cord-006229-7yoilsho	4971	19	)	)	-RRB-
cord-006229-7yoilsho	4971	20	were	be	VBD
cord-006229-7yoilsho	4971	21	tested	test	VBN
cord-006229-7yoilsho	4971	22	in	in	IN
cord-006229-7yoilsho	4971	23	DYT1	DYT1	NNP
cord-006229-7yoilsho	4971	24	knock	knock	VB
cord-006229-7yoilsho	4971	25	-	-	HYPH
cord-006229-7yoilsho	4971	26	in	in	NN
cord-006229-7yoilsho	4971	27	and	and	CC
cord-006229-7yoilsho	4971	28	wildtype	wildtype	NN
cord-006229-7yoilsho	4971	29	mice	mouse	NNS
cord-006229-7yoilsho	4971	30	.	.	.
cord-006229-7yoilsho	4972	1	Subsequent	subsequent	JJ
cord-006229-7yoilsho	4972	2	to	to	IN
cord-006229-7yoilsho	4972	3	the	the	DT
cord-006229-7yoilsho	4972	4	injections	injection	NNS
cord-006229-7yoilsho	4972	5	,	,	,
cord-006229-7yoilsho	4972	6	mice	mouse	NNS
cord-006229-7yoilsho	4972	7	were	be	VBD
cord-006229-7yoilsho	4972	8	tested	test	VBN
cord-006229-7yoilsho	4972	9	in	in	IN
cord-006229-7yoilsho	4972	10	the	the	DT
cord-006229-7yoilsho	4972	11	open	open	JJ
cord-006229-7yoilsho	4972	12	field	field	NN
cord-006229-7yoilsho	4972	13	,	,	,
cord-006229-7yoilsho	4972	14	the	the	DT
cord-006229-7yoilsho	4972	15	rotating	rotate	VBG
cord-006229-7yoilsho	4972	16	beam	beam	NN
cord-006229-7yoilsho	4972	17	test	test	NN
cord-006229-7yoilsho	4972	18	and	and	CC
cord-006229-7yoilsho	4972	19	the	the	DT
cord-006229-7yoilsho	4972	20	adhesive	adhesive	JJ
cord-006229-7yoilsho	4972	21	removal	removal	NN
cord-006229-7yoilsho	4972	22	test	test	NN
cord-006229-7yoilsho	4972	23	,	,	,
cord-006229-7yoilsho	4972	24	respectively	respectively	RB
cord-006229-7yoilsho	4972	25	.	.	.
cord-006229-7yoilsho	4973	1	In	in	IN
cord-006229-7yoilsho	4973	2	the	the	DT
cord-006229-7yoilsho	4973	3	open	open	JJ
cord-006229-7yoilsho	4973	4	field	field	NN
cord-006229-7yoilsho	4973	5	test	test	NN
cord-006229-7yoilsho	4973	6	,	,	,
cord-006229-7yoilsho	4973	7	DYT1	DYT1	NNP
cord-006229-7yoilsho	4973	8	knock	knock	VB
cord-006229-7yoilsho	4973	9	-	-	HYPH
cord-006229-7yoilsho	4973	10	in	in	RP
cord-006229-7yoilsho	4973	11	mice	mouse	NNS
cord-006229-7yoilsho	4973	12	showed	show	VBD
cord-006229-7yoilsho	4973	13	increased	increase	VBN
cord-006229-7yoilsho	4973	14	thigmotaxis	thigmotaxis	NNP
cord-006229-7yoilsho	4973	15	at	at	IN
cord-006229-7yoilsho	4973	16	a	a	DT
cord-006229-7yoilsho	4973	17	dose	dose	NN
cord-006229-7yoilsho	4973	18	of	of	IN
cord-006229-7yoilsho	4973	19	0.5	0.5	CD
cord-006229-7yoilsho	4973	20	mg	mg	NNP
cord-006229-7yoilsho	4973	21	/	/	SYM
cord-006229-7yoilsho	4973	22	kg	kg	NNP
cord-006229-7yoilsho	4973	23	quinpirole	quinpirole	NNP
cord-006229-7yoilsho	4973	24	.	.	.
cord-006229-7yoilsho	4974	1	In	in	IN
cord-006229-7yoilsho	4974	2	the	the	DT
cord-006229-7yoilsho	4974	3	rotating	rotate	VBG
cord-006229-7yoilsho	4974	4	beam	beam	NN
cord-006229-7yoilsho	4974	5	test	test	NN
cord-006229-7yoilsho	4974	6	,	,	,
cord-006229-7yoilsho	4974	7	both	both	DT
cord-006229-7yoilsho	4974	8	groups	group	NNS
cord-006229-7yoilsho	4974	9	showed	show	VBD
cord-006229-7yoilsho	4974	10	a	a	DT
cord-006229-7yoilsho	4974	11	dose	dose	NN
cord-006229-7yoilsho	4974	12	-	-	HYPH
cord-006229-7yoilsho	4974	13	dependently	dependently	RB
cord-006229-7yoilsho	4974	14	reduced	reduce	VBN
cord-006229-7yoilsho	4974	15	performance	performance	NN
cord-006229-7yoilsho	4974	16	.	.	.
cord-006229-7yoilsho	4975	1	In	in	IN
cord-006229-7yoilsho	4975	2	the	the	DT
cord-006229-7yoilsho	4975	3	adhesive	adhesive	JJ
cord-006229-7yoilsho	4975	4	removal	removal	NN
cord-006229-7yoilsho	4975	5	test	test	NN
cord-006229-7yoilsho	4975	6	,	,	,
cord-006229-7yoilsho	4975	7	quinpirole	quinpirole	NNP
cord-006229-7yoilsho	4975	8	improved	improve	VBD
cord-006229-7yoilsho	4975	9	the	the	DT
cord-006229-7yoilsho	4975	10	reaction	reaction	NN
cord-006229-7yoilsho	4975	11	time	time	NN
cord-006229-7yoilsho	4975	12	in	in	IN
cord-006229-7yoilsho	4975	13	DYT1	DYT1	NNP
cord-006229-7yoilsho	4975	14	mice	mouse	NNS
cord-006229-7yoilsho	4975	15	independently	independently	RB
cord-006229-7yoilsho	4975	16	of	of	IN
cord-006229-7yoilsho	4975	17	dosage	dosage	NN
cord-006229-7yoilsho	4975	18	,	,	,
cord-006229-7yoilsho	4975	19	while	while	IN
cord-006229-7yoilsho	4975	20	no	no	DT
cord-006229-7yoilsho	4975	21	effects	effect	NNS
cord-006229-7yoilsho	4975	22	were	be	VBD
cord-006229-7yoilsho	4975	23	observed	observe	VBN
cord-006229-7yoilsho	4975	24	in	in	IN
cord-006229-7yoilsho	4975	25	the	the	DT
cord-006229-7yoilsho	4975	26	wildtype	wildtype	NN
cord-006229-7yoilsho	4975	27	littermates	littermate	NNS
cord-006229-7yoilsho	4975	28	.	.	.
cord-006229-7yoilsho	4976	1	However	however	RB
cord-006229-7yoilsho	4976	2	,	,	,
cord-006229-7yoilsho	4976	3	in	in	IN
cord-006229-7yoilsho	4976	4	vehicle	vehicle	NN
cord-006229-7yoilsho	4976	5	follow	follow	NN
cord-006229-7yoilsho	4976	6	-	-	HYPH
cord-006229-7yoilsho	4976	7	up	up	NN
cord-006229-7yoilsho	4976	8	(	(	-LRB-
cord-006229-7yoilsho	4976	9	post	post	JJ
cord-006229-7yoilsho	4976	10	-	-	JJ
cord-006229-7yoilsho	4976	11	drug	drug	JJ
cord-006229-7yoilsho	4976	12	control	control	NN
cord-006229-7yoilsho	4976	13	)	)	-RRB-
cord-006229-7yoilsho	4976	14	,	,	,
cord-006229-7yoilsho	4976	15	this	this	DT
cord-006229-7yoilsho	4976	16	effect	effect	NN
cord-006229-7yoilsho	4976	17	remained	remain	VBD
cord-006229-7yoilsho	4976	18	consistent	consistent	JJ
cord-006229-7yoilsho	4976	19	in	in	IN
cord-006229-7yoilsho	4976	20	the	the	DT
cord-006229-7yoilsho	4976	21	DYT1	DYT1	NNP
cord-006229-7yoilsho	4976	22	model	model	NN
cord-006229-7yoilsho	4976	23	,	,	,
cord-006229-7yoilsho	4976	24	suggesting	suggest	VBG
cord-006229-7yoilsho	4976	25	a	a	DT
cord-006229-7yoilsho	4976	26	habituation	habituation	NN
cord-006229-7yoilsho	4976	27	effect	effect	NN
cord-006229-7yoilsho	4976	28	.	.	.
cord-006229-7yoilsho	4977	1	In	in	IN
cord-006229-7yoilsho	4977	2	conclusion	conclusion	NN
cord-006229-7yoilsho	4977	3	,	,	,
cord-006229-7yoilsho	4977	4	we	-PRON-	PRP
cord-006229-7yoilsho	4977	5	generated	generate	VBD
cord-006229-7yoilsho	4977	6	a	a	DT
cord-006229-7yoilsho	4977	7	new	new	JJ
cord-006229-7yoilsho	4977	8	test	test	NN
cord-006229-7yoilsho	4977	9	,	,	,
cord-006229-7yoilsho	4977	10	i.e.	i.e.	FW
cord-006229-7yoilsho	4977	11	,	,	,
cord-006229-7yoilsho	4977	12	the	the	DT
cord-006229-7yoilsho	4977	13	rotating	rotate	VBG
cord-006229-7yoilsho	4977	14	beam	beam	NN
cord-006229-7yoilsho	4977	15	test	test	NN
cord-006229-7yoilsho	4977	16	which	which	WDT
cord-006229-7yoilsho	4977	17	improves	improve	VBZ
cord-006229-7yoilsho	4977	18	the	the	DT
cord-006229-7yoilsho	4977	19	detection	detection	NN
cord-006229-7yoilsho	4977	20	of	of	IN
cord-006229-7yoilsho	4977	21	mild	mild	JJ
cord-006229-7yoilsho	4977	22	motor	motor	NN
cord-006229-7yoilsho	4977	23	impairments	impairment	NNS
cord-006229-7yoilsho	4977	24	in	in	IN
cord-006229-7yoilsho	4977	25	DYT1	DYT1	NNP
cord-006229-7yoilsho	4977	26	knock	knock	VB
cord-006229-7yoilsho	4977	27	-	-	HYPH
cord-006229-7yoilsho	4977	28	in	in	RP
cord-006229-7yoilsho	4977	29	mice	mouse	NNS
cord-006229-7yoilsho	4977	30	.	.	.
cord-006229-7yoilsho	4978	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	4978	2	,	,	,
cord-006229-7yoilsho	4978	3	the	the	DT
cord-006229-7yoilsho	4978	4	adhesive	adhesive	JJ
cord-006229-7yoilsho	4978	5	removal	removal	NN
cord-006229-7yoilsho	4978	6	test	test	NN
cord-006229-7yoilsho	4978	7	revealed	reveal	VBD
cord-006229-7yoilsho	4978	8	sensorimotor	sensorimotor	JJ
cord-006229-7yoilsho	4978	9	dysfunctions	dysfunction	NNS
cord-006229-7yoilsho	4978	10	in	in	IN
cord-006229-7yoilsho	4978	11	this	this	DT
cord-006229-7yoilsho	4978	12	animal	animal	NN
cord-006229-7yoilsho	4978	13	model	model	NN
cord-006229-7yoilsho	4978	14	.	.	.
cord-006229-7yoilsho	4979	1	These	these	DT
cord-006229-7yoilsho	4979	2	results	result	NNS
cord-006229-7yoilsho	4979	3	represent	represent	VBP
cord-006229-7yoilsho	4979	4	an	an	DT
cord-006229-7yoilsho	4979	5	important	important	JJ
cord-006229-7yoilsho	4979	6	step	step	NN
cord-006229-7yoilsho	4979	7	for	for	IN
cord-006229-7yoilsho	4979	8	our	-PRON-	PRP$
cord-006229-7yoilsho	4979	9	ongoing	ongoing	JJ
cord-006229-7yoilsho	4979	10	optogenetic	optogenetic	JJ
cord-006229-7yoilsho	4979	11	examinations	examination	NNS
cord-006229-7yoilsho	4979	12	on	on	IN
cord-006229-7yoilsho	4979	13	the	the	DT
cord-006229-7yoilsho	4979	14	role	role	NN
cord-006229-7yoilsho	4979	15	of	of	IN
cord-006229-7yoilsho	4979	16	abnormal	abnormal	JJ
cord-006229-7yoilsho	4979	17	neuronal	neuronal	JJ
cord-006229-7yoilsho	4979	18	plasticity	plasticity	NN
cord-006229-7yoilsho	4979	19	in	in	IN
cord-006229-7yoilsho	4979	20	DYT1	DYT1	NNP
cord-006229-7yoilsho	4979	21	dystonia	dystonia	NN
cord-006229-7yoilsho	4979	22	and	and	CC
cord-006229-7yoilsho	4979	23	for	for	IN
cord-006229-7yoilsho	4979	24	pharmacological	pharmacological	JJ
cord-006229-7yoilsho	4979	25	studies	study	NNS
cord-006229-7yoilsho	4979	26	.	.	.
cord-006229-7yoilsho	4980	1	The	the	DT
cord-006229-7yoilsho	4980	2	first	first	JJ
cord-006229-7yoilsho	4980	3	data	datum	NNS
cord-006229-7yoilsho	4980	4	on	on	IN
cord-006229-7yoilsho	4980	5	the	the	DT
cord-006229-7yoilsho	4980	6	effects	effect	NNS
cord-006229-7yoilsho	4980	7	of	of	IN
cord-006229-7yoilsho	4980	8	quinpirole	quinpirole	NN
cord-006229-7yoilsho	4980	9	do	do	VBP
cord-006229-7yoilsho	4980	10	not	not	RB
cord-006229-7yoilsho	4980	11	indicate	indicate	VB
cord-006229-7yoilsho	4980	12	a	a	DT
cord-006229-7yoilsho	4980	13	critical	critical	JJ
cord-006229-7yoilsho	4980	14	role	role	NN
cord-006229-7yoilsho	4980	15	of	of	IN
cord-006229-7yoilsho	4980	16	D2	d2	NN
cord-006229-7yoilsho	4980	17	dysregulated	dysregulate	VBN
cord-006229-7yoilsho	4980	18	acetylcholine	acetylcholine	NN
cord-006229-7yoilsho	4980	19	release	release	NN
cord-006229-7yoilsho	4980	20	,	,	,
cord-006229-7yoilsho	4980	21	but	but	CC
cord-006229-7yoilsho	4980	22	this	this	DT
cord-006229-7yoilsho	4980	23	has	have	VBZ
cord-006229-7yoilsho	4980	24	to	to	TO
cord-006229-7yoilsho	4980	25	be	be	VB
cord-006229-7yoilsho	4980	26	clarified	clarify	VBN
cord-006229-7yoilsho	4980	27	by	by	IN
cord-006229-7yoilsho	4980	28	ongoing	ongoing	JJ
cord-006229-7yoilsho	4980	29	local	local	JJ
cord-006229-7yoilsho	4980	30	striatal	striatal	JJ
cord-006229-7yoilsho	4980	31	injections	injection	NNS
cord-006229-7yoilsho	4980	32	of	of	IN
cord-006229-7yoilsho	4980	33	quinpirole	quinpirole	NN
cord-006229-7yoilsho	4980	34	and	and	CC
cord-006229-7yoilsho	4980	35	by	by	IN
cord-006229-7yoilsho	4980	36	pharmacological	pharmacological	JJ
cord-006229-7yoilsho	4980	37	manipulations	manipulation	NNS
cord-006229-7yoilsho	4980	38	of	of	IN
cord-006229-7yoilsho	4980	39	the	the	DT
cord-006229-7yoilsho	4980	40	cholinergic	cholinergic	JJ
cord-006229-7yoilsho	4980	41	system	system	NN
cord-006229-7yoilsho	4980	42	.	.	.
cord-006229-7yoilsho	4981	1	Renal	renal	JJ
cord-006229-7yoilsho	4981	2	fibrosis	fibrosis	NN
cord-006229-7yoilsho	4981	3	is	be	VBZ
cord-006229-7yoilsho	4981	4	characterized	characterize	VBN
cord-006229-7yoilsho	4981	5	by	by	IN
cord-006229-7yoilsho	4981	6	decreased	decrease	VBN
cord-006229-7yoilsho	4981	7	nitric	nitric	NN
cord-006229-7yoilsho	4981	8	oxide	oxide	NN
cord-006229-7yoilsho	4981	9	(	(	-LRB-
cord-006229-7yoilsho	4981	10	NO	no	DT
cord-006229-7yoilsho	4981	11	)	)	-RRB-
cord-006229-7yoilsho	4981	12	bioavailability	bioavailability	NN
cord-006229-7yoilsho	4981	13	and	and	CC
cord-006229-7yoilsho	4981	14	pronounced	pronounce	VBD
cord-006229-7yoilsho	4981	15	transforming	transform	VBG
cord-006229-7yoilsho	4981	16	growth	growth	NN
cord-006229-7yoilsho	4981	17	factor	factor	NN
cord-006229-7yoilsho	4981	18	β	β	NNP
cord-006229-7yoilsho	4981	19	(	(	-LRB-
cord-006229-7yoilsho	4981	20	TGFβ	TGFβ	NNP
cord-006229-7yoilsho	4981	21	)	)	-RRB-
cord-006229-7yoilsho	4981	22	signalling	signal	VBG
cord-006229-7yoilsho	4981	23	subsequently	subsequently	RB
cord-006229-7yoilsho	4981	24	excessive	excessive	JJ
cord-006229-7yoilsho	4981	25	extracellular	extracellular	JJ
cord-006229-7yoilsho	4981	26	matrix	matrix	NN
cord-006229-7yoilsho	4981	27	(	(	-LRB-
cord-006229-7yoilsho	4981	28	ECM	ECM	NNP
cord-006229-7yoilsho	4981	29	)	)	-RRB-
cord-006229-7yoilsho	4981	30	deposition	deposition	NN
cord-006229-7yoilsho	4981	31	.	.	.
cord-006229-7yoilsho	4982	1	Here	here	RB
cord-006229-7yoilsho	4982	2	,	,	,
cord-006229-7yoilsho	4982	3	the	the	DT
cord-006229-7yoilsho	4982	4	effects	effect	NNS
cord-006229-7yoilsho	4982	5	of	of	IN
cord-006229-7yoilsho	4982	6	the	the	DT
cord-006229-7yoilsho	4982	7	soluble	soluble	JJ
cord-006229-7yoilsho	4982	8	guanylate	guanylate	NN
cord-006229-7yoilsho	4982	9	cyclase	cyclase	NN
cord-006229-7yoilsho	4982	10	(	(	-LRB-
cord-006229-7yoilsho	4982	11	sGC	sGC	NNP
cord-006229-7yoilsho	4982	12	)	)	-RRB-
cord-006229-7yoilsho	4982	13	stimulator	stimulator	NN
cord-006229-7yoilsho	4982	14	BAY	BAY	NNP
cord-006229-7yoilsho	4982	15	41	41	CD
cord-006229-7yoilsho	4982	16	-	-	SYM
cord-006229-7yoilsho	4982	17	8543	8543	CD
cord-006229-7yoilsho	4982	18	after	after	IN
cord-006229-7yoilsho	4982	19	unilateral	unilateral	JJ
cord-006229-7yoilsho	4982	20	ureter	ureter	JJ
cord-006229-7yoilsho	4982	21	obstruction	obstruction	NN
cord-006229-7yoilsho	4982	22	(	(	-LRB-
cord-006229-7yoilsho	4982	23	UUO	UUO	NNP
cord-006229-7yoilsho	4982	24	)	)	-RRB-
cord-006229-7yoilsho	4982	25	have	have	VBP
cord-006229-7yoilsho	4982	26	been	be	VBN
cord-006229-7yoilsho	4982	27	studied	study	VBN
cord-006229-7yoilsho	4982	28	.	.	.
cord-006229-7yoilsho	4983	1	Kidney	kidney	NN
cord-006229-7yoilsho	4983	2	fibrosis	fibrosis	NN
cord-006229-7yoilsho	4983	3	was	be	VBD
cord-006229-7yoilsho	4983	4	induced	induce	VBN
cord-006229-7yoilsho	4983	5	by	by	IN
cord-006229-7yoilsho	4983	6	unilateral	unilateral	JJ
cord-006229-7yoilsho	4983	7	ureter	ureter	JJ
cord-006229-7yoilsho	4983	8	obstruction	obstruction	NN
cord-006229-7yoilsho	4983	9	(	(	-LRB-
cord-006229-7yoilsho	4983	10	UUO	UUO	NNP
cord-006229-7yoilsho	4983	11	)	)	-RRB-
cord-006229-7yoilsho	4983	12	in	in	IN
cord-006229-7yoilsho	4983	13	wild	wild	JJ
cord-006229-7yoilsho	4983	14	type	type	NN
cord-006229-7yoilsho	4983	15	(	(	-LRB-
cord-006229-7yoilsho	4983	16	WT	WT	NNP
cord-006229-7yoilsho	4983	17	)	)	-RRB-
cord-006229-7yoilsho	4983	18	and	and	CC
cord-006229-7yoilsho	4983	19	cGKI	cGKI	NNP
cord-006229-7yoilsho	4983	20	knock	knock	VB
cord-006229-7yoilsho	4983	21	-	-	HYPH
cord-006229-7yoilsho	4983	22	out	out	NN
cord-006229-7yoilsho	4983	23	(	(	-LRB-
cord-006229-7yoilsho	4983	24	cGKI	cgki	FW
cord-006229-7yoilsho	4983	25	KO	KO	NNP
cord-006229-7yoilsho	4983	26	)	)	-RRB-
cord-006229-7yoilsho	4983	27	mice	mouse	NNS
cord-006229-7yoilsho	4983	28	.	.	.
cord-006229-7yoilsho	4984	1	Starting	start	VBG
cord-006229-7yoilsho	4984	2	one	one	CD
cord-006229-7yoilsho	4984	3	day	day	NN
cord-006229-7yoilsho	4984	4	after	after	IN
cord-006229-7yoilsho	4984	5	UUO	UUO	NNP
cord-006229-7yoilsho	4984	6	,	,	,
cord-006229-7yoilsho	4984	7	the	the	DT
cord-006229-7yoilsho	4984	8	sGC	sGC	NNP
cord-006229-7yoilsho	4984	9	stimulator	stimulator	NNP
cord-006229-7yoilsho	4984	10	BAY	BAY	NNP
cord-006229-7yoilsho	4984	11	41	41	CD
cord-006229-7yoilsho	4984	12	-	-	SYM
cord-006229-7yoilsho	4984	13	8543	8543	CD
cord-006229-7yoilsho	4984	14	was	be	VBD
cord-006229-7yoilsho	4984	15	(	(	-LRB-
cord-006229-7yoilsho	4984	16	4mg	4mg	NNP
cord-006229-7yoilsho	4984	17	/	/	SYM
cord-006229-7yoilsho	4984	18	kg	kg	NN
cord-006229-7yoilsho	4984	19	/	/	SYM
cord-006229-7yoilsho	4984	20	daily	daily	RB
cord-006229-7yoilsho	4985	1	)	)	-RRB-
cord-006229-7yoilsho	4985	2	i.	i.	NN
cord-006229-7yoilsho	4985	3	p.	p.	NN
cord-006229-7yoilsho	4985	4	injected	inject	VBD
cord-006229-7yoilsho	4985	5	for	for	IN
cord-006229-7yoilsho	4985	6	seven	seven	CD
cord-006229-7yoilsho	4985	7	days	day	NNS
cord-006229-7yoilsho	4985	8	.	.	.
cord-006229-7yoilsho	4986	1	Biomarkers	biomarker	NNS
cord-006229-7yoilsho	4986	2	indicating	indicate	VBG
cord-006229-7yoilsho	4986	3	remodelling	remodelle	VBG
cord-006229-7yoilsho	4986	4	processes	process	NNS
cord-006229-7yoilsho	4986	5	in	in	IN
cord-006229-7yoilsho	4986	6	the	the	DT
cord-006229-7yoilsho	4986	7	kidney	kidney	NN
cord-006229-7yoilsho	4986	8	were	be	VBD
cord-006229-7yoilsho	4986	9	analysed	analyse	VBN
cord-006229-7yoilsho	4986	10	via	via	IN
cord-006229-7yoilsho	4986	11	mRNA	mrna	NN
cord-006229-7yoilsho	4986	12	expression	expression	NN
cord-006229-7yoilsho	4986	13	and	and	CC
cord-006229-7yoilsho	4986	14	protein	protein	NN
cord-006229-7yoilsho	4986	15	expression	expression	NN
cord-006229-7yoilsho	4986	16	.	.	.
cord-006229-7yoilsho	4987	1	BAY	BAY	NNP
cord-006229-7yoilsho	4987	2	41	41	CD
cord-006229-7yoilsho	4987	3	-	-	SYM
cord-006229-7yoilsho	4987	4	8543	8543	CD
cord-006229-7yoilsho	4987	5	administration	administration	NN
cord-006229-7yoilsho	4987	6	influenced	influence	VBD
cord-006229-7yoilsho	4987	7	the	the	DT
cord-006229-7yoilsho	4987	8	activity	activity	NN
cord-006229-7yoilsho	4987	9	of	of	IN
cord-006229-7yoilsho	4987	10	the	the	DT
cord-006229-7yoilsho	4987	11	ECM	ECM	NNP
cord-006229-7yoilsho	4987	12	degrading	degrade	VBG
cord-006229-7yoilsho	4987	13	matrix	matrix	NN
cord-006229-7yoilsho	4987	14	metalloproteases	metalloprotease	NNS
cord-006229-7yoilsho	4987	15	(	(	-LRB-
cord-006229-7yoilsho	4987	16	MMP2	MMP2	NNP
cord-006229-7yoilsho	4987	17	and	and	CC
cord-006229-7yoilsho	4987	18	MMP9	MMP9	NNP
cord-006229-7yoilsho	4987	19	)	)	-RRB-
cord-006229-7yoilsho	4987	20	and	and	CC
cord-006229-7yoilsho	4987	21	their	-PRON-	PRP$
cord-006229-7yoilsho	4987	22	inhibitor	inhibitor	NN
cord-006229-7yoilsho	4987	23	TIMP-1	TIMP-1	NNP
cord-006229-7yoilsho	4987	24	,	,	,
cord-006229-7yoilsho	4987	25	the	the	DT
cord-006229-7yoilsho	4987	26	expression	expression	NN
cord-006229-7yoilsho	4987	27	pattern	pattern	NN
cord-006229-7yoilsho	4987	28	of	of	IN
cord-006229-7yoilsho	4987	29	extracellular	extracellular	JJ
cord-006229-7yoilsho	4987	30	matrix	matrix	NN
cord-006229-7yoilsho	4987	31	proteins	protein	NNS
cord-006229-7yoilsho	4987	32	(	(	-LRB-
cord-006229-7yoilsho	4987	33	e.g.	e.g.	RB
cord-006229-7yoilsho	4987	34	Collagen	collagen	NN
cord-006229-7yoilsho	4987	35	and	and	CC
cord-006229-7yoilsho	4987	36	fibronectin	fibronectin	NN
cord-006229-7yoilsho	4987	37	)	)	-RRB-
cord-006229-7yoilsho	4987	38	of	of	IN
cord-006229-7yoilsho	4987	39	profibrotic	profibrotic	JJ
cord-006229-7yoilsho	4987	40	mediators	mediator	NNS
cord-006229-7yoilsho	4987	41	(	(	-LRB-
cord-006229-7yoilsho	4987	42	e.g.	e.g.	IN
cord-006229-7yoilsho	4987	43	connective	connective	JJ
cord-006229-7yoilsho	4987	44	tissue	tissue	NN
cord-006229-7yoilsho	4987	45	growth	growth	NN
cord-006229-7yoilsho	4987	46	factors	factor	NNS
cord-006229-7yoilsho	4987	47	(	(	-LRB-
cord-006229-7yoilsho	4987	48	CTGF	CTGF	NNP
cord-006229-7yoilsho	4987	49	)	)	-RRB-
cord-006229-7yoilsho	4987	50	and	and	CC
cord-006229-7yoilsho	4987	51	plasminogen	plasminogen	NN
cord-006229-7yoilsho	4987	52	-	-	HYPH
cord-006229-7yoilsho	4987	53	activator	activator	NN
cord-006229-7yoilsho	4987	54	inhibitor-1	inhibitor-1	NNP
cord-006229-7yoilsho	4987	55	(	(	-LRB-
cord-006229-7yoilsho	4987	56	PAI-1	PAI-1	NNP
cord-006229-7yoilsho	4987	57	)	)	-RRB-
cord-006229-7yoilsho	4987	58	)	)	-RRB-
cord-006229-7yoilsho	4987	59	and	and	CC
cord-006229-7yoilsho	4987	60	the	the	DT
cord-006229-7yoilsho	4987	61	secretion	secretion	NN
cord-006229-7yoilsho	4987	62	of	of	IN
cord-006229-7yoilsho	4987	63	cytokines	cytokine	NNS
cord-006229-7yoilsho	4987	64	,	,	,
cord-006229-7yoilsho	4987	65	e.g.	e.g.	RB
cord-006229-7yoilsho	4987	66	IL-6	IL-6	NNP
cord-006229-7yoilsho	4987	67	.	.	.
cord-006229-7yoilsho	4988	1	Thereby	thereby	RB
cord-006229-7yoilsho	4988	2	,	,	,
cord-006229-7yoilsho	4988	3	BAY	BAY	NNP
cord-006229-7yoilsho	4988	4	41	41	CD
cord-006229-7yoilsho	4988	5	-	-	SYM
cord-006229-7yoilsho	4988	6	8543	8543	CD
cord-006229-7yoilsho	4988	7	increments	increment	NNS
cord-006229-7yoilsho	4989	1	the	the	DT
cord-006229-7yoilsho	4989	2	cGMP	cGMP	NNP
cord-006229-7yoilsho	4989	3	pool	pool	NN
cord-006229-7yoilsho	4989	4	among	among	IN
cord-006229-7yoilsho	4989	5	others	other	NNS
cord-006229-7yoilsho	4989	6	via	via	IN
cord-006229-7yoilsho	4989	7	modulation	modulation	NN
cord-006229-7yoilsho	4989	8	of	of	IN
cord-006229-7yoilsho	4989	9	endothelial	endothelial	JJ
cord-006229-7yoilsho	4989	10	NO	no	DT
cord-006229-7yoilsho	4989	11	synthase	synthase	NN
cord-006229-7yoilsho	4989	12	(	(	-LRB-
cord-006229-7yoilsho	4989	13	eNOS	enos	JJ
cord-006229-7yoilsho	4989	14	)	)	-RRB-
cord-006229-7yoilsho	4989	15	expression	expression	NN
cord-006229-7yoilsho	4989	16	.	.	.
cord-006229-7yoilsho	4990	1	Agents	agent	NNS
cord-006229-7yoilsho	4990	2	,	,	,
cord-006229-7yoilsho	4990	3	which	which	WDT
cord-006229-7yoilsho	4990	4	enhance	enhance	VBP
cord-006229-7yoilsho	4990	5	NO	no	NN
cord-006229-7yoilsho	4990	6	and	and	CC
cord-006229-7yoilsho	4990	7	cyclic	cyclic	JJ
cord-006229-7yoilsho	4990	8	guanosine	guanosine	NN
cord-006229-7yoilsho	4990	9	monophosphate	monophosphate	NN
cord-006229-7yoilsho	4990	10	(	(	-LRB-
cord-006229-7yoilsho	4990	11	cGMP	cGMP	NNP
cord-006229-7yoilsho	4990	12	)	)	-RRB-
cord-006229-7yoilsho	4990	13	ameliorate	ameliorate	VB
cord-006229-7yoilsho	4990	14	the	the	DT
cord-006229-7yoilsho	4990	15	progression	progression	NN
cord-006229-7yoilsho	4990	16	of	of	IN
cord-006229-7yoilsho	4990	17	fibrotic	fibrotic	JJ
cord-006229-7yoilsho	4990	18	tissue	tissue	NN
cord-006229-7yoilsho	4990	19	.	.	.
cord-006229-7yoilsho	4991	1	However	however	RB
cord-006229-7yoilsho	4991	2	,	,	,
cord-006229-7yoilsho	4991	3	the	the	DT
cord-006229-7yoilsho	4991	4	molecular	molecular	JJ
cord-006229-7yoilsho	4991	5	mechanism	mechanism	NN
cord-006229-7yoilsho	4991	6	by	by	IN
cord-006229-7yoilsho	4991	7	which	which	WDT
cord-006229-7yoilsho	4991	8	cGMP	cGMP	NNP
cord-006229-7yoilsho	4991	9	via	via	IN
cord-006229-7yoilsho	4991	10	cGKI	cGKI	NNP
cord-006229-7yoilsho	4991	11	affects	affect	VBZ
cord-006229-7yoilsho	4991	12	the	the	DT
cord-006229-7yoilsho	4991	13	development	development	NN
cord-006229-7yoilsho	4991	14	of	of	IN
cord-006229-7yoilsho	4991	15	kidney	kidney	NN
cord-006229-7yoilsho	4991	16	fibrosis	fibrosis	NN
cord-006229-7yoilsho	4991	17	has	have	VBZ
cord-006229-7yoilsho	4991	18	not	not	RB
cord-006229-7yoilsho	4991	19	fully	fully	RB
cord-006229-7yoilsho	4991	20	been	be	VBN
cord-006229-7yoilsho	4991	21	elucidated	elucidate	VBN
cord-006229-7yoilsho	4991	22	.	.	.
cord-006229-7yoilsho	4992	1	Accordingly	accordingly	RB
cord-006229-7yoilsho	4992	2	,	,	,
cord-006229-7yoilsho	4992	3	the	the	DT
cord-006229-7yoilsho	4992	4	present	present	JJ
cord-006229-7yoilsho	4992	5	study	study	NN
cord-006229-7yoilsho	4992	6	investigates	investigate	VBZ
cord-006229-7yoilsho	4992	7	the	the	DT
cord-006229-7yoilsho	4992	8	functional	functional	JJ
cord-006229-7yoilsho	4992	9	role	role	NN
cord-006229-7yoilsho	4992	10	of	of	IN
cord-006229-7yoilsho	4992	11	sGC	sGC	NNS
cord-006229-7yoilsho	4992	12	stimulation	stimulation	NN
cord-006229-7yoilsho	4992	13	in	in	IN
cord-006229-7yoilsho	4992	14	regulating	regulate	VBG
cord-006229-7yoilsho	4992	15	the	the	DT
cord-006229-7yoilsho	4992	16	fibrotic	fibrotic	JJ
cord-006229-7yoilsho	4992	17	process	process	NN
cord-006229-7yoilsho	4992	18	,	,	,
cord-006229-7yoilsho	4992	19	the	the	DT
cord-006229-7yoilsho	4992	20	signalling	signal	VBG
cord-006229-7yoilsho	4992	21	pathway	pathway	NN
cord-006229-7yoilsho	4992	22	and	and	CC
cord-006229-7yoilsho	4992	23	the	the	DT
cord-006229-7yoilsho	4992	24	underlying	underlie	VBG
cord-006229-7yoilsho	4992	25	mechanisms	mechanism	NNS
cord-006229-7yoilsho	4992	26	involved	involve	VBN
cord-006229-7yoilsho	4992	27	.	.	.
cord-006229-7yoilsho	4993	1	We	-PRON-	PRP
cord-006229-7yoilsho	4993	2	hypothesize	hypothesize	VBP
cord-006229-7yoilsho	4993	3	that	that	IN
cord-006229-7yoilsho	4993	4	the	the	DT
cord-006229-7yoilsho	4993	5	antifibrotic	antifibrotic	JJ
cord-006229-7yoilsho	4993	6	potential	potential	NN
cord-006229-7yoilsho	4993	7	of	of	IN
cord-006229-7yoilsho	4993	8	BAY	BAY	NNP
cord-006229-7yoilsho	4993	9	41	41	CD
cord-006229-7yoilsho	4993	10	-	-	SYM
cord-006229-7yoilsho	4993	11	8543	8543	CD
cord-006229-7yoilsho	4993	12	might	may	MD
cord-006229-7yoilsho	4993	13	be	be	VB
cord-006229-7yoilsho	4993	14	related	relate	VBN
cord-006229-7yoilsho	4993	15	to	to	IN
cord-006229-7yoilsho	4993	16	the	the	DT
cord-006229-7yoilsho	4993	17	increased	increase	VBN
cord-006229-7yoilsho	4993	18	cGMP	cGMP	NNP
cord-006229-7yoilsho	4993	19	pool	pool	NN
cord-006229-7yoilsho	4993	20	and	and	CC
cord-006229-7yoilsho	4993	21	the	the	DT
cord-006229-7yoilsho	4993	22	inhibition	inhibition	NN
cord-006229-7yoilsho	4993	23	of	of	IN
cord-006229-7yoilsho	4993	24	the	the	DT
cord-006229-7yoilsho	4993	25	MAPK	MAPK	NNP
cord-006229-7yoilsho	4993	26	and	and	CC
cord-006229-7yoilsho	4993	27	smad	smad	NNP
cord-006229-7yoilsho	4993	28	signalling	signal	VBG
cord-006229-7yoilsho	4993	29	pathway	pathway	NN
cord-006229-7yoilsho	4993	30	.	.	.
cord-006229-7yoilsho	4994	1	The	the	DT
cord-006229-7yoilsho	4994	2	elucidation	elucidation	NN
cord-006229-7yoilsho	4994	3	of	of	IN
cord-006229-7yoilsho	4994	4	the	the	DT
cord-006229-7yoilsho	4994	5	signalling	signalling	NN
cord-006229-7yoilsho	4994	6	allows	allow	VBZ
cord-006229-7yoilsho	4994	7	the	the	DT
cord-006229-7yoilsho	4994	8	development	development	NN
cord-006229-7yoilsho	4994	9	of	of	IN
cord-006229-7yoilsho	4994	10	new	new	JJ
cord-006229-7yoilsho	4994	11	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	4994	12	options	option	NNS
cord-006229-7yoilsho	4994	13	.	.	.
cord-006229-7yoilsho	4995	1	Infection	infection	NN
cord-006229-7yoilsho	4995	2	of	of	IN
cord-006229-7yoilsho	4995	3	mice	mouse	NNS
cord-006229-7yoilsho	4995	4	with	with	IN
cord-006229-7yoilsho	4995	5	Listeria	Listeria	NNP
cord-006229-7yoilsho	4995	6	monocytogenes	monocytogenes	NNP
cord-006229-7yoilsho	4995	7	(	(	-LRB-
cord-006229-7yoilsho	4995	8	LM	LM	NNP
cord-006229-7yoilsho	4995	9	)	)	-RRB-
cord-006229-7yoilsho	4995	10	results	result	VBZ
cord-006229-7yoilsho	4995	11	in	in	IN
cord-006229-7yoilsho	4995	12	a	a	DT
cord-006229-7yoilsho	4995	13	strong	strong	JJ
cord-006229-7yoilsho	4995	14	T	t	NN
cord-006229-7yoilsho	4995	15	-	-	HYPH
cord-006229-7yoilsho	4995	16	cell	cell	NN
cord-006229-7yoilsho	4995	17	response	response	NN
cord-006229-7yoilsho	4995	18	that	that	WDT
cord-006229-7yoilsho	4995	19	is	be	VBZ
cord-006229-7yoilsho	4995	20	critical	critical	JJ
cord-006229-7yoilsho	4995	21	for	for	IN
cord-006229-7yoilsho	4995	22	an	an	DT
cord-006229-7yoilsho	4995	23	efficient	efficient	JJ
cord-006229-7yoilsho	4995	24	defense	defense	NN
cord-006229-7yoilsho	4995	25	.	.	.
cord-006229-7yoilsho	4996	1	Here	here	RB
cord-006229-7yoilsho	4996	2	,	,	,
cord-006229-7yoilsho	4996	3	we	-PRON-	PRP
cord-006229-7yoilsho	4996	4	demonstrate	demonstrate	VBP
cord-006229-7yoilsho	4996	5	that	that	IN
cord-006229-7yoilsho	4996	6	the	the	DT
cord-006229-7yoilsho	4996	7	adapter	adapter	NN
cord-006229-7yoilsho	4996	8	protein	protein	NN
cord-006229-7yoilsho	4996	9	SLy1	SLy1	VBN
cord-006229-7yoilsho	4996	10	(	(	-LRB-
cord-006229-7yoilsho	4996	11	SH3-domain	SH3-domain	NNP
cord-006229-7yoilsho	4996	12	protein	protein	NN
cord-006229-7yoilsho	4996	13	expressed	express	VBD
cord-006229-7yoilsho	4996	14	inLymphocytes	inLymphocytes	NNP
cord-006229-7yoilsho	4996	15	1	1	CD
cord-006229-7yoilsho	4996	16	)	)	-RRB-
cord-006229-7yoilsho	4996	17	is	be	VBZ
cord-006229-7yoilsho	4996	18	essential	essential	JJ
cord-006229-7yoilsho	4996	19	for	for	IN
cord-006229-7yoilsho	4996	20	the	the	DT
cord-006229-7yoilsho	4996	21	generation	generation	NN
cord-006229-7yoilsho	4996	22	of	of	IN
cord-006229-7yoilsho	4996	23	a	a	DT
cord-006229-7yoilsho	4996	24	fully	fully	RB
cord-006229-7yoilsho	4996	25	functional	functional	JJ
cord-006229-7yoilsho	4996	26	T	t	NN
cord-006229-7yoilsho	4996	27	-	-	HYPH
cord-006229-7yoilsho	4996	28	cell	cell	NN
cord-006229-7yoilsho	4996	29	response	response	NN
cord-006229-7yoilsho	4996	30	.	.	.
cord-006229-7yoilsho	4997	1	The	the	DT
cord-006229-7yoilsho	4997	2	lack	lack	NN
cord-006229-7yoilsho	4997	3	of	of	IN
cord-006229-7yoilsho	4997	4	SLy1	SLy1	NNS
cord-006229-7yoilsho	4997	5	leads	lead	VBZ
cord-006229-7yoilsho	4997	6	to	to	IN
cord-006229-7yoilsho	4997	7	reduced	reduce	VBN
cord-006229-7yoilsho	4997	8	survival	survival	NN
cord-006229-7yoilsho	4997	9	rates	rate	NNS
cord-006229-7yoilsho	4997	10	of	of	IN
cord-006229-7yoilsho	4997	11	infected	infected	JJ
cord-006229-7yoilsho	4997	12	mice	mouse	NNS
cord-006229-7yoilsho	4997	13	.	.	.
cord-006229-7yoilsho	4998	1	The	the	DT
cord-006229-7yoilsho	4998	2	increased	increase	VBN
cord-006229-7yoilsho	4998	3	susceptibility	susceptibility	NN
cord-006229-7yoilsho	4998	4	of	of	IN
cord-006229-7yoilsho	4998	5	SLy1	SLy1	NNP
cord-006229-7yoilsho	4998	6	KO	KO	NNP
cord-006229-7yoilsho	4998	7	mice	mouse	NNS
cord-006229-7yoilsho	4998	8	was	be	VBD
cord-006229-7yoilsho	4998	9	caused	cause	VBN
cord-006229-7yoilsho	4998	10	by	by	IN
cord-006229-7yoilsho	4998	11	reduced	reduce	VBN
cord-006229-7yoilsho	4998	12	proliferation	proliferation	NN
cord-006229-7yoilsho	4998	13	of	of	IN
cord-006229-7yoilsho	4998	14	differentiated	differentiate	VBN
cord-006229-7yoilsho	4998	15	T	t	NN
cord-006229-7yoilsho	4998	16	cells	cell	NNS
cord-006229-7yoilsho	4998	17	.	.	.
cord-006229-7yoilsho	4999	1	Ex	Ex	NNP
cord-006229-7yoilsho	4999	2	vivo	vivo	NN
cord-006229-7yoilsho	4999	3	analyses	analysis	NNS
cord-006229-7yoilsho	4999	4	of	of	IN
cord-006229-7yoilsho	4999	5	isolated	isolated	JJ
cord-006229-7yoilsho	4999	6	SLy1	SLy1	NNP
cord-006229-7yoilsho	4999	7	KO	KO	NNP
cord-006229-7yoilsho	4999	8	T	T	NNP
cord-006229-7yoilsho	4999	9	cells	cell	NNS
cord-006229-7yoilsho	4999	10	displayed	display	VBD
cord-006229-7yoilsho	4999	11	a	a	DT
cord-006229-7yoilsho	4999	12	dysregulation	dysregulation	NN
cord-006229-7yoilsho	4999	13	of	of	IN
cord-006229-7yoilsho	4999	14	Forkhead	Forkhead	NNP
cord-006229-7yoilsho	4999	15	box	box	NN
cord-006229-7yoilsho	4999	16	protein	protein	NN
cord-006229-7yoilsho	4999	17	O1	o1	NN
cord-006229-7yoilsho	4999	18	(	(	-LRB-
cord-006229-7yoilsho	4999	19	Foxo1	Foxo1	NNP
cord-006229-7yoilsho	4999	20	)	)	-RRB-
cord-006229-7yoilsho	4999	21	shuttling	shuttle	VBG
cord-006229-7yoilsho	4999	22	after	after	IN
cord-006229-7yoilsho	4999	23	TCR	TCR	NNP
cord-006229-7yoilsho	4999	24	signaling	signaling	NN
cord-006229-7yoilsho	4999	25	,	,	,
cord-006229-7yoilsho	4999	26	which	which	WDT
cord-006229-7yoilsho	4999	27	resulted	result	VBD
cord-006229-7yoilsho	4999	28	in	in	IN
cord-006229-7yoilsho	4999	29	an	an	DT
cord-006229-7yoilsho	4999	30	increased	increase	VBN
cord-006229-7yoilsho	4999	31	expression	expression	NN
cord-006229-7yoilsho	4999	32	of	of	IN
cord-006229-7yoilsho	4999	33	cell	cell	NN
cord-006229-7yoilsho	4999	34	cycle	cycle	NN
cord-006229-7yoilsho	4999	35	inhibiting	inhibit	VBG
cord-006229-7yoilsho	4999	36	genes	gene	NNS
cord-006229-7yoilsho	4999	37	,	,	,
cord-006229-7yoilsho	4999	38	and	and	CC
cord-006229-7yoilsho	4999	39	therefore	therefore	RB
cord-006229-7yoilsho	4999	40	,	,	,
cord-006229-7yoilsho	4999	41	reduced	reduce	VBN
cord-006229-7yoilsho	4999	42	expansion	expansion	NN
cord-006229-7yoilsho	4999	43	of	of	IN
cord-006229-7yoilsho	4999	44	the	the	DT
cord-006229-7yoilsho	4999	45	T	t	NN
cord-006229-7yoilsho	4999	46	-	-	HYPH
cord-006229-7yoilsho	4999	47	cell	cell	NN
cord-006229-7yoilsho	4999	48	population	population	NN
cord-006229-7yoilsho	4999	49	.	.	.
cord-006229-7yoilsho	5000	1	Foxo1	Foxo1	NNP
cord-006229-7yoilsho	5000	2	shuttles	shuttle	NNS
cord-006229-7yoilsho	5000	3	to	to	IN
cord-006229-7yoilsho	5000	4	the	the	DT
cord-006229-7yoilsho	5000	5	cytoplasm	cytoplasm	NN
cord-006229-7yoilsho	5000	6	after	after	IN
cord-006229-7yoilsho	5000	7	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	5000	8	in	in	IN
cord-006229-7yoilsho	5000	9	a	a	DT
cord-006229-7yoilsho	5000	10	protein	protein	NN
cord-006229-7yoilsho	5000	11	complex	complex	NN
cord-006229-7yoilsho	5000	12	including	include	VBG
cord-006229-7yoilsho	5000	13	14	14	CD
cord-006229-7yoilsho	5000	14	-	-	SYM
cord-006229-7yoilsho	5000	15	3	3	CD
cord-006229-7yoilsho	5000	16	-	-	SYM
cord-006229-7yoilsho	5000	17	3	3	CD
cord-006229-7yoilsho	5000	18	proteins	protein	NNS
cord-006229-7yoilsho	5000	19	.	.	.
cord-006229-7yoilsho	5001	1	Interestingly	interestingly	RB
cord-006229-7yoilsho	5001	2	,	,	,
cord-006229-7yoilsho	5001	3	we	-PRON-	PRP
cord-006229-7yoilsho	5001	4	observed	observe	VBD
cord-006229-7yoilsho	5001	5	a	a	DT
cord-006229-7yoilsho	5001	6	similar	similar	JJ
cord-006229-7yoilsho	5001	7	regulation	regulation	NN
cord-006229-7yoilsho	5001	8	for	for	IN
cord-006229-7yoilsho	5001	9	the	the	DT
cord-006229-7yoilsho	5001	10	adapter	adapter	NN
cord-006229-7yoilsho	5001	11	protein	protein	NN
cord-006229-7yoilsho	5001	12	SLy1	SLy1	NNP
cord-006229-7yoilsho	5001	13	,	,	,
cord-006229-7yoilsho	5001	14	where	where	WRB
cord-006229-7yoilsho	5001	15	TCR	TCR	NNP
cord-006229-7yoilsho	5001	16	stimulation	stimulation	NN
cord-006229-7yoilsho	5001	17	results	result	NNS
cord-006229-7yoilsho	5001	18	in	in	IN
cord-006229-7yoilsho	5001	19	SLy1	sly1	JJ
cord-006229-7yoilsho	5001	20	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	5001	21	and	and	CC
cord-006229-7yoilsho	5001	22	SLy1	sly1	JJ
cord-006229-7yoilsho	5001	23	export	export	NN
cord-006229-7yoilsho	5001	24	to	to	IN
cord-006229-7yoilsho	5001	25	the	the	DT
cord-006229-7yoilsho	5001	26	cytoplasm	cytoplasm	NN
cord-006229-7yoilsho	5001	27	.	.	.
cord-006229-7yoilsho	5002	1	Moreover	moreover	RB
cord-006229-7yoilsho	5002	2	,	,	,
cord-006229-7yoilsho	5002	3	immunoprecipitation	immunoprecipitation	NN
cord-006229-7yoilsho	5002	4	analyses	analysis	NNS
cord-006229-7yoilsho	5002	5	revealed	reveal	VBD
cord-006229-7yoilsho	5002	6	a	a	DT
cord-006229-7yoilsho	5002	7	binding	binding	NN
cord-006229-7yoilsho	5002	8	of	of	IN
cord-006229-7yoilsho	5002	9	SLy1	SLy1	NNS
cord-006229-7yoilsho	5002	10	to	to	IN
cord-006229-7yoilsho	5002	11	14	14	CD
cord-006229-7yoilsho	5002	12	-	-	SYM
cord-006229-7yoilsho	5002	13	3	3	CD
cord-006229-7yoilsho	5002	14	-	-	SYM
cord-006229-7yoilsho	5002	15	3	3	CD
cord-006229-7yoilsho	5002	16	proteins	protein	NNS
cord-006229-7yoilsho	5002	17	.	.	.
cord-006229-7yoilsho	5003	1	Altogether	altogether	RB
cord-006229-7yoilsho	5003	2	,	,	,
cord-006229-7yoilsho	5003	3	this	this	DT
cord-006229-7yoilsho	5003	4	study	study	NN
cord-006229-7yoilsho	5003	5	describes	describe	VBZ
cord-006229-7yoilsho	5003	6	SLy1	SLy1	VBN
cord-006229-7yoilsho	5003	7	as	as	IN
cord-006229-7yoilsho	5003	8	an	an	DT
cord-006229-7yoilsho	5003	9	immunoregulatory	immunoregulatory	JJ
cord-006229-7yoilsho	5003	10	protein	protein	NN
cord-006229-7yoilsho	5003	11	,	,	,
cord-006229-7yoilsho	5003	12	which	which	WDT
cord-006229-7yoilsho	5003	13	is	be	VBZ
cord-006229-7yoilsho	5003	14	involved	involve	VBN
cord-006229-7yoilsho	5003	15	in	in	IN
cord-006229-7yoilsho	5003	16	the	the	DT
cord-006229-7yoilsho	5003	17	generation	generation	NN
cord-006229-7yoilsho	5003	18	of	of	IN
cord-006229-7yoilsho	5003	19	adaptive	adaptive	JJ
cord-006229-7yoilsho	5003	20	immune	immune	JJ
cord-006229-7yoilsho	5003	21	responses	response	NNS
cord-006229-7yoilsho	5003	22	during	during	IN
cord-006229-7yoilsho	5003	23	LM	LM	NNP
cord-006229-7yoilsho	5003	24	infection	infection	NN
cord-006229-7yoilsho	5003	25	,	,	,
cord-006229-7yoilsho	5003	26	and	and	CC
cord-006229-7yoilsho	5003	27	provides	provide	VBZ
cord-006229-7yoilsho	5003	28	a	a	DT
cord-006229-7yoilsho	5003	29	model	model	NN
cord-006229-7yoilsho	5003	30	of	of	IN
cord-006229-7yoilsho	5003	31	how	how	WRB
cord-006229-7yoilsho	5003	32	SLy1	SLy1	NNP
cord-006229-7yoilsho	5003	33	regulates	regulate	VBZ
cord-006229-7yoilsho	5003	34	T	t	NN
cord-006229-7yoilsho	5003	35	-	-	HYPH
cord-006229-7yoilsho	5003	36	cell	cell	NN
cord-006229-7yoilsho	5003	37	proliferation	proliferation	NN
cord-006229-7yoilsho	5004	1	(	(	-LRB-
cord-006229-7yoilsho	5004	2	Schäll	Schäll	NNP
cord-006229-7yoilsho	5004	3	et	et	FW
cord-006229-7yoilsho	5004	4	al	al	NNP
cord-006229-7yoilsho	5004	5	.	.	.
cord-006229-7yoilsho	5005	1	,	,	,
cord-006229-7yoilsho	5005	2	Eur	Eur	NNP
cord-006229-7yoilsho	5005	3	J	J	NNP
cord-006229-7yoilsho	5005	4	Immunol	Immunol	NNP
cord-006229-7yoilsho	5005	5	.	.	.
cord-006229-7yoilsho	5005	6	2015	2015	CD
cord-006229-7yoilsho	5005	7	)	)	-RRB-
cord-006229-7yoilsho	5005	8	.	.	.
cord-006229-7yoilsho	5006	1	The	the	DT
cord-006229-7yoilsho	5006	2	catalytical	catalytical	JJ
cord-006229-7yoilsho	5006	3	isoforms	isoform	NNS
cord-006229-7yoilsho	5006	4	p110γ	p110γ	ADD
cord-006229-7yoilsho	5006	5	and	and	CC
cord-006229-7yoilsho	5006	6	p110δ	p110δ	NNPS
cord-006229-7yoilsho	5006	7	of	of	IN
cord-006229-7yoilsho	5006	8	phosphatidylinositol-4,5-bisphosphate	phosphatidylinositol-4,5-bisphosphate	NN
cord-006229-7yoilsho	5007	1	3kinase	3kinase	LS
cord-006229-7yoilsho	5007	2	γ	γ	NNP
cord-006229-7yoilsho	5007	3	(	(	-LRB-
cord-006229-7yoilsho	5007	4	PI3Kγ	PI3Kγ	NNP
cord-006229-7yoilsho	5007	5	)	)	-RRB-
cord-006229-7yoilsho	5007	6	and	and	CC
cord-006229-7yoilsho	5007	7	PI3Kδ	PI3Kδ	NNP
cord-006229-7yoilsho	5007	8	play	play	VBP
cord-006229-7yoilsho	5007	9	an	an	DT
cord-006229-7yoilsho	5007	10	important	important	JJ
cord-006229-7yoilsho	5007	11	role	role	NN
cord-006229-7yoilsho	5007	12	in	in	IN
cord-006229-7yoilsho	5007	13	the	the	DT
cord-006229-7yoilsho	5007	14	pathogenesis	pathogenesis	NN
cord-006229-7yoilsho	5007	15	of	of	IN
cord-006229-7yoilsho	5007	16	asthma	asthma	NN
cord-006229-7yoilsho	5007	17	.	.	.
cord-006229-7yoilsho	5008	1	Two	two	CD
cord-006229-7yoilsho	5008	2	key	key	JJ
cord-006229-7yoilsho	5008	3	elements	element	NNS
cord-006229-7yoilsho	5008	4	in	in	IN
cord-006229-7yoilsho	5008	5	allergic	allergic	JJ
cord-006229-7yoilsho	5008	6	asthma	asthma	NN
cord-006229-7yoilsho	5008	7	are	be	VBP
cord-006229-7yoilsho	5008	8	increased	increase	VBN
cord-006229-7yoilsho	5008	9	eosinophil	eosinophil	NN
cord-006229-7yoilsho	5008	10	and	and	CC
cord-006229-7yoilsho	5008	11	IgE	IgE	NNP
cord-006229-7yoilsho	5008	12	levels	level	NNS
cord-006229-7yoilsho	5008	13	.	.	.
cord-006229-7yoilsho	5009	1	Whereas	whereas	IN
cord-006229-7yoilsho	5009	2	dual	dual	JJ
cord-006229-7yoilsho	5009	3	pharmacological	pharmacological	JJ
cord-006229-7yoilsho	5009	4	inhibition	inhibition	NN
cord-006229-7yoilsho	5009	5	of	of	IN
cord-006229-7yoilsho	5009	6	the	the	DT
cord-006229-7yoilsho	5009	7	catalytical	catalytical	JJ
cord-006229-7yoilsho	5009	8	subunits	subunit	NNS
cord-006229-7yoilsho	5009	9	p110γ	p110γ	CD
cord-006229-7yoilsho	5009	10	and	and	CC
cord-006229-7yoilsho	5009	11	p110δ	p110δ	NNPS
cord-006229-7yoilsho	5009	12	reduces	reduce	VBZ
cord-006229-7yoilsho	5009	13	asthmaassociated	asthmaassociated	NNP
cord-006229-7yoilsho	5009	14	eosinophilic	eosinophilic	JJ
cord-006229-7yoilsho	5009	15	lung	lung	NN
cord-006229-7yoilsho	5009	16	infiltration	infiltration	NN
cord-006229-7yoilsho	5009	17	and	and	CC
cord-006229-7yoilsho	5009	18	ameliorates	ameliorate	VBZ
cord-006229-7yoilsho	5009	19	disease	disease	NN
cord-006229-7yoilsho	5009	20	symptoms	symptom	NNS
cord-006229-7yoilsho	5009	21	,	,	,
cord-006229-7yoilsho	5009	22	it	-PRON-	PRP
cord-006229-7yoilsho	5009	23	has	have	VBZ
cord-006229-7yoilsho	5009	24	been	be	VBN
cord-006229-7yoilsho	5009	25	shown	show	VBN
cord-006229-7yoilsho	5009	26	that	that	IN
cord-006229-7yoilsho	5009	27	dual	dual	JJ
cord-006229-7yoilsho	5009	28	genetic	genetic	JJ
cord-006229-7yoilsho	5009	29	deficiency	deficiency	NN
cord-006229-7yoilsho	5009	30	in	in	IN
cord-006229-7yoilsho	5009	31	PI3Kγ	PI3Kγ	NNP
cord-006229-7yoilsho	5009	32	and	and	CC
cord-006229-7yoilsho	5009	33	PI3Kδ	PI3Kδ	NNP
cord-006229-7yoilsho	5009	34	in	in	IN
cord-006229-7yoilsho	5009	35	p110γ	p110γ	CD
cord-006229-7yoilsho	5009	36	KO	KO	NNP
cord-006229-7yoilsho	5009	37	δ	δ	NN
cord-006229-7yoilsho	5009	38	D910A	d910a	JJ
cord-006229-7yoilsho	5009	39	mice	mouse	NNS
cord-006229-7yoilsho	5009	40	increases	increase	VBZ
cord-006229-7yoilsho	5009	41	serum	serum	NNP
cord-006229-7yoilsho	5009	42	IgE	IgE	NNP
cord-006229-7yoilsho	5009	43	and	and	CC
cord-006229-7yoilsho	5009	44	basal	basal	JJ
cord-006229-7yoilsho	5009	45	eosinophil	eosinophil	JJ
cord-006229-7yoilsho	5009	46	counts	count	VBZ
cord-006229-7yoilsho	5009	47	in	in	IN
cord-006229-7yoilsho	5009	48	mucosal	mucosal	JJ
cord-006229-7yoilsho	5009	49	tissues	tissue	NNS
cord-006229-7yoilsho	5009	50	and	and	CC
cord-006229-7yoilsho	5009	51	blood	blood	NN
cord-006229-7yoilsho	5009	52	.	.	.
cord-006229-7yoilsho	5010	1	This	this	DT
cord-006229-7yoilsho	5010	2	suggests	suggest	VBZ
cord-006229-7yoilsho	5010	3	that	that	IN
cord-006229-7yoilsho	5010	4	long	long	JJ
cord-006229-7yoilsho	5010	5	-	-	HYPH
cord-006229-7yoilsho	5010	6	term	term	NN
cord-006229-7yoilsho	5010	7	inhibition	inhibition	NN
cord-006229-7yoilsho	5010	8	of	of	IN
cord-006229-7yoilsho	5010	9	p110γ	p110γ	CD
cord-006229-7yoilsho	5010	10	and	and	CC
cord-006229-7yoilsho	5010	11	p110δ	p110δ	NNPS
cord-006229-7yoilsho	5010	12	might	may	MD
cord-006229-7yoilsho	5010	13	exacerbate	exacerbate	VB
cord-006229-7yoilsho	5010	14	asthma	asthma	NN
cord-006229-7yoilsho	5010	15	.	.	.
cord-006229-7yoilsho	5011	1	Here	here	RB
cord-006229-7yoilsho	5011	2	we	-PRON-	PRP
cord-006229-7yoilsho	5011	3	analysed	analyse	VBD
cord-006229-7yoilsho	5011	4	p110γ/	p110γ/	NN
cord-006229-7yoilsho	5012	1	δ	δ	NNP
cord-006229-7yoilsho	5012	2	-/mice	-/mice	NNP
cord-006229-7yoilsho	5012	3	and	and	CC
cord-006229-7yoilsho	5012	4	determined	determine	VBD
cord-006229-7yoilsho	5012	5	IgE	IgE	NNP
cord-006229-7yoilsho	5012	6	and	and	CC
cord-006229-7yoilsho	5012	7	eosinophil	eosinophil	NN
cord-006229-7yoilsho	5012	8	counts	count	VBZ
cord-006229-7yoilsho	5012	9	in	in	IN
cord-006229-7yoilsho	5012	10	a	a	DT
cord-006229-7yoilsho	5012	11	basal	basal	NN
cord-006229-7yoilsho	5012	12	state	state	NN
cord-006229-7yoilsho	5012	13	and	and	CC
cord-006229-7yoilsho	5012	14	the	the	DT
cord-006229-7yoilsho	5012	15	immune	immune	JJ
cord-006229-7yoilsho	5012	16	response	response	NN
cord-006229-7yoilsho	5012	17	to	to	IN
cord-006229-7yoilsho	5012	18	ovalbumin	ovalbumin	FW
cord-006229-7yoilsho	5012	19	(	(	-LRB-
cord-006229-7yoilsho	5012	20	OVA)-induced	ova)-induce	VBN
cord-006229-7yoilsho	5012	21	allergic	allergic	JJ
cord-006229-7yoilsho	5012	22	asthma	asthma	NN
cord-006229-7yoilsho	5012	23	.	.	.
cord-006229-7yoilsho	5013	1	We	-PRON-	PRP
cord-006229-7yoilsho	5013	2	found	find	VBD
cord-006229-7yoilsho	5013	3	that	that	IN
cord-006229-7yoilsho	5013	4	serum	serum	NN
cord-006229-7yoilsho	5013	5	concentrations	concentration	NNS
cord-006229-7yoilsho	5013	6	of	of	IN
cord-006229-7yoilsho	5013	7	IgE	IgE	NNP
cord-006229-7yoilsho	5013	8	,	,	,
cord-006229-7yoilsho	5013	9	IL-5	IL-5	NNP
cord-006229-7yoilsho	5013	10	and	and	CC
cord-006229-7yoilsho	5013	11	eosinophil	eosinophil	JJ
cord-006229-7yoilsho	5013	12	numbers	number	NNS
cord-006229-7yoilsho	5013	13	in	in	IN
cord-006229-7yoilsho	5013	14	blood	blood	NN
cord-006229-7yoilsho	5013	15	,	,	,
cord-006229-7yoilsho	5013	16	spleen	spleen	NN
cord-006229-7yoilsho	5013	17	and	and	CC
cord-006229-7yoilsho	5013	18	bone	bone	NN
cord-006229-7yoilsho	5013	19	marrow	marrow	NN
cord-006229-7yoilsho	5013	20	were	be	VBD
cord-006229-7yoilsho	5013	21	significantly	significantly	RB
cord-006229-7yoilsho	5013	22	increased	increase	VBN
cord-006229-7yoilsho	5013	23	in	in	IN
cord-006229-7yoilsho	5013	24	p110γ	p110γ	ADD
cord-006229-7yoilsho	5014	1	/δ	/δ	JJ
cord-006229-7yoilsho	5014	2	-/mice	-/mice	NNP
cord-006229-7yoilsho	5015	1	in	in	IN
cord-006229-7yoilsho	5015	2	comparison	comparison	NN
cord-006229-7yoilsho	5015	3	to	to	IN
cord-006229-7yoilsho	5015	4	single	single	JJ
cord-006229-7yoilsho	5015	5	knock	knock	NN
cord-006229-7yoilsho	5015	6	-	-	HYPH
cord-006229-7yoilsho	5015	7	out	out	NN
cord-006229-7yoilsho	5015	8	(	(	-LRB-
cord-006229-7yoilsho	5015	9	KO	KO	NNP
cord-006229-7yoilsho	5015	10	)	)	-RRB-
cord-006229-7yoilsho	5015	11	and	and	CC
cord-006229-7yoilsho	5015	12	wildtype	wildtype	NN
cord-006229-7yoilsho	5015	13	(	(	-LRB-
cord-006229-7yoilsho	5015	14	WT	WT	NNP
cord-006229-7yoilsho	5015	15	)	)	-RRB-
cord-006229-7yoilsho	5015	16	mice	mouse	NNS
cord-006229-7yoilsho	5015	17	.	.	.
cord-006229-7yoilsho	5016	1	Nevertheless	nevertheless	RB
cord-006229-7yoilsho	5016	2	,	,	,
cord-006229-7yoilsho	5016	3	p110γ	p110γ	ADD
cord-006229-7yoilsho	5016	4	/	/	SYM
cord-006229-7yoilsho	5016	5	δ	δ	NN
cord-006229-7yoilsho	5016	6	-/mice	-/mice	NNP
cord-006229-7yoilsho	5016	7	were	be	VBD
cord-006229-7yoilsho	5016	8	protected	protect	VBN
cord-006229-7yoilsho	5016	9	against	against	IN
cord-006229-7yoilsho	5016	10	OVAinduced	ovainduced	JJ
cord-006229-7yoilsho	5016	11	infiltration	infiltration	NN
cord-006229-7yoilsho	5016	12	of	of	IN
cord-006229-7yoilsho	5016	13	eosinophils	eosinophil	NNS
cord-006229-7yoilsho	5016	14	,	,	,
cord-006229-7yoilsho	5016	15	neutrophils	neutrophil	NNS
cord-006229-7yoilsho	5016	16	,	,	,
cord-006229-7yoilsho	5016	17	B	b	NN
cord-006229-7yoilsho	5016	18	cells	cell	NNS
cord-006229-7yoilsho	5016	19	and	and	CC
cord-006229-7yoilsho	5016	20	T	t	NN
cord-006229-7yoilsho	5016	21	cells	cell	NNS
cord-006229-7yoilsho	5016	22	into	into	IN
cord-006229-7yoilsho	5016	23	the	the	DT
cord-006229-7yoilsho	5016	24	lung	lung	NN
cord-006229-7yoilsho	5016	25	tissue	tissue	NN
cord-006229-7yoilsho	5016	26	and	and	CC
cord-006229-7yoilsho	5016	27	the	the	DT
cord-006229-7yoilsho	5016	28	bronchoalveolar	bronchoalveolar	JJ
cord-006229-7yoilsho	5016	29	space	space	NN
cord-006229-7yoilsho	5016	30	.	.	.
cord-006229-7yoilsho	5017	1	Moreover	moreover	RB
cord-006229-7yoilsho	5017	2	,	,	,
cord-006229-7yoilsho	5017	3	p110γ	p110γ	ADD
cord-006229-7yoilsho	5017	4	/	/	SYM
cord-006229-7yoilsho	5017	5	δ	δ	NNP
cord-006229-7yoilsho	5017	6	-/mice	-/mice	NNP
cord-006229-7yoilsho	5017	7	,	,	,
cord-006229-7yoilsho	5017	8	but	but	CC
cord-006229-7yoilsho	5017	9	not	not	RB
cord-006229-7yoilsho	5017	10	single	single	JJ
cord-006229-7yoilsho	5017	11	KO	KO	NNP
cord-006229-7yoilsho	5017	12	mice	mouse	NNS
cord-006229-7yoilsho	5017	13	,	,	,
cord-006229-7yoilsho	5017	14	showed	show	VBD
cord-006229-7yoilsho	5017	15	a	a	DT
cord-006229-7yoilsho	5017	16	reduced	reduce	VBN
cord-006229-7yoilsho	5017	17	bronchial	bronchial	JJ
cord-006229-7yoilsho	5017	18	hyperresponsiveness	hyperresponsiveness	NN
cord-006229-7yoilsho	5017	19	as	as	IN
cord-006229-7yoilsho	5017	20	measured	measure	VBN
cord-006229-7yoilsho	5017	21	with	with	IN
cord-006229-7yoilsho	5017	22	the	the	DT
cord-006229-7yoilsho	5017	23	isolated	isolated	JJ
cord-006229-7yoilsho	5017	24	and	and	CC
cord-006229-7yoilsho	5017	25	perfused	perfuse	VBN
cord-006229-7yoilsho	5017	26	lung	lung	NN
cord-006229-7yoilsho	5017	27	.	.	.
cord-006229-7yoilsho	5018	1	We	-PRON-	PRP
cord-006229-7yoilsho	5018	2	conclude	conclude	VBP
cord-006229-7yoilsho	5018	3	that	that	IN
cord-006229-7yoilsho	5018	4	although	although	IN
cord-006229-7yoilsho	5018	5	the	the	DT
cord-006229-7yoilsho	5018	6	dual	dual	JJ
cord-006229-7yoilsho	5018	7	deficiency	deficiency	NN
cord-006229-7yoilsho	5018	8	of	of	IN
cord-006229-7yoilsho	5018	9	p110γ	p110γ	CD
cord-006229-7yoilsho	5018	10	and	and	CC
cord-006229-7yoilsho	5018	11	p110δ	p110δ	NNPS
cord-006229-7yoilsho	5018	12	causes	cause	VBZ
cord-006229-7yoilsho	5018	13	eosinophilia	eosinophilia	NNP
cord-006229-7yoilsho	5018	14	and	and	CC
cord-006229-7yoilsho	5018	15	IgE	IgE	NNP
cord-006229-7yoilsho	5018	16	hyperproduction	hyperproduction	NNP
cord-006229-7yoilsho	5018	17	,	,	,
cord-006229-7yoilsho	5018	18	p110γ	p110γ	ADD
cord-006229-7yoilsho	5019	1	/δ	/δ	JJ
cord-006229-7yoilsho	5019	2	-/mice	-/mice	NNP
cord-006229-7yoilsho	5019	3	are	be	VBP
cord-006229-7yoilsho	5019	4	not	not	RB
cord-006229-7yoilsho	5019	5	prone	prone	JJ
cord-006229-7yoilsho	5019	6	to	to	TO
cord-006229-7yoilsho	5019	7	develop	develop	VB
cord-006229-7yoilsho	5019	8	OVAinduced	ovainduced	JJ
cord-006229-7yoilsho	5019	9	allergic	allergic	JJ
cord-006229-7yoilsho	5019	10	asthma	asthma	NN
cord-006229-7yoilsho	5019	11	.	.	.
cord-006229-7yoilsho	5020	1	An	an	DT
cord-006229-7yoilsho	5020	2	increase	increase	NN
cord-006229-7yoilsho	5020	3	of	of	IN
cord-006229-7yoilsho	5020	4	plasma	plasma	NN
cord-006229-7yoilsho	5020	5	extravasation	extravasation	NN
cord-006229-7yoilsho	5020	6	induced	induce	VBN
cord-006229-7yoilsho	5020	7	by	by	IN
cord-006229-7yoilsho	5020	8	activation	activation	NN
cord-006229-7yoilsho	5020	9	of	of	IN
cord-006229-7yoilsho	5020	10	constitutively	constitutively	RB
cord-006229-7yoilsho	5020	11	expressed	express	VBN
cord-006229-7yoilsho	5020	12	endothelial	endothelial	JJ
cord-006229-7yoilsho	5020	13	bradykinin	bradykinin	NN
cord-006229-7yoilsho	5020	14	type	type	NN
cord-006229-7yoilsho	5020	15	2	2	CD
cord-006229-7yoilsho	5020	16	receptors	receptor	NNS
cord-006229-7yoilsho	5020	17	(	(	-LRB-
cord-006229-7yoilsho	5020	18	B2	b2	NN
cord-006229-7yoilsho	5020	19	)	)	-RRB-
cord-006229-7yoilsho	5020	20	has	have	VBZ
cord-006229-7yoilsho	5020	21	been	be	VBN
cord-006229-7yoilsho	5020	22	shown	show	VBN
cord-006229-7yoilsho	5020	23	to	to	TO
cord-006229-7yoilsho	5020	24	contribute	contribute	VB
cord-006229-7yoilsho	5020	25	to	to	IN
cord-006229-7yoilsho	5020	26	the	the	DT
cord-006229-7yoilsho	5020	27	development	development	NN
cord-006229-7yoilsho	5020	28	of	of	IN
cord-006229-7yoilsho	5020	29	angioedema	angioedema	NN
cord-006229-7yoilsho	5020	30	occurring	occur	VBG
cord-006229-7yoilsho	5020	31	as	as	IN
cord-006229-7yoilsho	5020	32	a	a	DT
cord-006229-7yoilsho	5020	33	sometimes	sometimes	RB
cord-006229-7yoilsho	5020	34	life	life	NN
cord-006229-7yoilsho	5020	35	-	-	HYPH
cord-006229-7yoilsho	5020	36	threatening	threaten	VBG
cord-006229-7yoilsho	5020	37	side	side	NN
cord-006229-7yoilsho	5020	38	effect	effect	NN
cord-006229-7yoilsho	5020	39	of	of	IN
cord-006229-7yoilsho	5020	40	angiotensin	angiotensin	NN
cord-006229-7yoilsho	5020	41	-	-	HYPH
cord-006229-7yoilsho	5020	42	converting	convert	VBG
cord-006229-7yoilsho	5020	43	enzyme	enzyme	NN
cord-006229-7yoilsho	5020	44	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	5020	45	such	such	JJ
cord-006229-7yoilsho	5020	46	as	as	IN
cord-006229-7yoilsho	5020	47	enalapril	enalapril	NNP
cord-006229-7yoilsho	5020	48	(	(	-LRB-
cord-006229-7yoilsho	5020	49	New	new	JJ
cord-006229-7yoilsho	5020	50	Engl	Engl	NNP
cord-006229-7yoilsho	5020	51	J	J	NNP
cord-006229-7yoilsho	5020	52	Med	Med	NNP
cord-006229-7yoilsho	5020	53	2015:372	2015:372	CD
cord-006229-7yoilsho	5020	54	;	;	:
cord-006229-7yoilsho	5020	55	418	418	CD
cord-006229-7yoilsho	5020	56	-	-	SYM
cord-006229-7yoilsho	5020	57	425	425	CD
cord-006229-7yoilsho	5020	58	)	)	-RRB-
cord-006229-7yoilsho	5020	59	.	.	.
cord-006229-7yoilsho	5021	1	These	these	DT
cord-006229-7yoilsho	5021	2	drugs	drug	NNS
cord-006229-7yoilsho	5021	3	inhibit	inhibit	VBP
cord-006229-7yoilsho	5021	4	the	the	DT
cord-006229-7yoilsho	5021	5	degradation	degradation	NN
cord-006229-7yoilsho	5021	6	of	of	IN
cord-006229-7yoilsho	5021	7	bradykinin	bradykinin	NN
cord-006229-7yoilsho	5021	8	and	and	CC
cord-006229-7yoilsho	5021	9	increase	increase	VB
cord-006229-7yoilsho	5021	10	its	-PRON-	PRP$
cord-006229-7yoilsho	5021	11	vascular	vascular	JJ
cord-006229-7yoilsho	5021	12	steady	steady	JJ
cord-006229-7yoilsho	5021	13	-	-	HYPH
cord-006229-7yoilsho	5021	14	state	state	NN
cord-006229-7yoilsho	5021	15	concentration	concentration	NN
cord-006229-7yoilsho	5021	16	.	.	.
cord-006229-7yoilsho	5022	1	Hence	hence	RB
cord-006229-7yoilsho	5022	2	,	,	,
cord-006229-7yoilsho	5022	3	it	-PRON-	PRP
cord-006229-7yoilsho	5022	4	is	be	VBZ
cord-006229-7yoilsho	5022	5	reasonable	reasonable	JJ
cord-006229-7yoilsho	5022	6	to	to	TO
cord-006229-7yoilsho	5022	7	assume	assume	VB
cord-006229-7yoilsho	5022	8	that	that	IN
cord-006229-7yoilsho	5022	9	bradykinin	bradykinin	NN
cord-006229-7yoilsho	5022	10	may	may	MD
cord-006229-7yoilsho	5022	11	destabilise	destabilise	VB
cord-006229-7yoilsho	5022	12	the	the	DT
cord-006229-7yoilsho	5022	13	endothelial	endothelial	JJ
cord-006229-7yoilsho	5022	14	barrier	barrier	NN
cord-006229-7yoilsho	5022	15	,	,	,
cord-006229-7yoilsho	5022	16	i.e.	i.e.	FW
cord-006229-7yoilsho	5022	17	may	may	MD
cord-006229-7yoilsho	5022	18	increase	increase	VB
cord-006229-7yoilsho	5022	19	physiologic	physiologic	JJ
cord-006229-7yoilsho	5022	20	extravasation	extravasation	NN
cord-006229-7yoilsho	5022	21	.	.	.
cord-006229-7yoilsho	5023	1	While	while	IN
cord-006229-7yoilsho	5023	2	the	the	DT
cord-006229-7yoilsho	5023	3	commonly	commonly	RB
cord-006229-7yoilsho	5023	4	used	use	VBN
cord-006229-7yoilsho	5023	5	Miles	Miles	NNP
cord-006229-7yoilsho	5023	6	assay	assay	NN
cord-006229-7yoilsho	5023	7	provides	provide	VBZ
cord-006229-7yoilsho	5023	8	a	a	DT
cord-006229-7yoilsho	5023	9	useful	useful	JJ
cord-006229-7yoilsho	5023	10	and	and	CC
cord-006229-7yoilsho	5023	11	relatively	relatively	RB
cord-006229-7yoilsho	5023	12	easy	easy	JJ
cord-006229-7yoilsho	5023	13	tool	tool	NN
cord-006229-7yoilsho	5023	14	to	to	TO
cord-006229-7yoilsho	5023	15	study	study	VB
cord-006229-7yoilsho	5023	16	the	the	DT
cord-006229-7yoilsho	5023	17	effect	effect	NN
cord-006229-7yoilsho	5023	18	of	of	IN
cord-006229-7yoilsho	5023	19	permeabilizing	permeabilize	VBG
cord-006229-7yoilsho	5023	20	mediators	mediator	NNS
cord-006229-7yoilsho	5023	21	in	in	IN
cord-006229-7yoilsho	5023	22	-	-	HYPH
cord-006229-7yoilsho	5023	23	vivo	vivo	NN
cord-006229-7yoilsho	5023	24	,	,	,
cord-006229-7yoilsho	5023	25	it	-PRON-	PRP
cord-006229-7yoilsho	5023	26	does	do	VBZ
cord-006229-7yoilsho	5023	27	not	not	RB
cord-006229-7yoilsho	5023	28	distinguish	distinguish	VB
cord-006229-7yoilsho	5023	29	between	between	IN
cord-006229-7yoilsho	5023	30	intravascular	intravascular	JJ
cord-006229-7yoilsho	5023	31	and	and	CC
cord-006229-7yoilsho	5023	32	interstitial	interstitial	JJ
cord-006229-7yoilsho	5023	33	Evan	Evan	NNP
cord-006229-7yoilsho	5023	34	's	's	POS
cord-006229-7yoilsho	5023	35	blue	blue	JJ
cord-006229-7yoilsho	5023	36	dye	dye	NN
cord-006229-7yoilsho	5023	37	.	.	.
cord-006229-7yoilsho	5024	1	Likewise	likewise	RB
cord-006229-7yoilsho	5024	2	,	,	,
cord-006229-7yoilsho	5024	3	extravasation	extravasation	NN
cord-006229-7yoilsho	5024	4	can	can	MD
cord-006229-7yoilsho	5024	5	only	only	RB
cord-006229-7yoilsho	5024	6	be	be	VB
cord-006229-7yoilsho	5024	7	quantified	quantify	VBN
cord-006229-7yoilsho	5024	8	at	at	IN
cord-006229-7yoilsho	5024	9	one	one	CD
cord-006229-7yoilsho	5024	10	particular	particular	JJ
cord-006229-7yoilsho	5024	11	time	time	NN
cord-006229-7yoilsho	5024	12	point	point	NN
cord-006229-7yoilsho	5024	13	per	per	IN
cord-006229-7yoilsho	5024	14	animal	animal	NN
cord-006229-7yoilsho	5024	15	,	,	,
cord-006229-7yoilsho	5024	16	usually	usually	RB
cord-006229-7yoilsho	5024	17	20	20	CD
cord-006229-7yoilsho	5024	18	-	-	SYM
cord-006229-7yoilsho	5024	19	30	30	CD
cord-006229-7yoilsho	5024	20	min	min	NN
cord-006229-7yoilsho	5024	21	.	.	.
cord-006229-7yoilsho	5025	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	5025	2	,	,	,
cord-006229-7yoilsho	5025	3	evaluation	evaluation	NN
cord-006229-7yoilsho	5025	4	of	of	IN
cord-006229-7yoilsho	5025	5	physiologic	physiologic	JJ
cord-006229-7yoilsho	5025	6	extravasation	extravasation	NN
cord-006229-7yoilsho	5025	7	is	be	VBZ
cord-006229-7yoilsho	5025	8	not	not	RB
cord-006229-7yoilsho	5025	9	possible	possible	JJ
cord-006229-7yoilsho	5025	10	.	.	.
cord-006229-7yoilsho	5026	1	In	in	IN
cord-006229-7yoilsho	5026	2	contrast	contrast	NN
cord-006229-7yoilsho	5026	3	,	,	,
cord-006229-7yoilsho	5026	4	non	non	JJ
cord-006229-7yoilsho	5026	5	-	-	JJ
cord-006229-7yoilsho	5026	6	invasive	invasive	JJ
cord-006229-7yoilsho	5026	7	twophoton	twophoton	NN
cord-006229-7yoilsho	5026	8	laser	laser	NN
cord-006229-7yoilsho	5026	9	microscopy	microscopy	NNS
cord-006229-7yoilsho	5026	10	may	may	MD
cord-006229-7yoilsho	5026	11	allow	allow	VB
cord-006229-7yoilsho	5026	12	separating	separate	VBG
cord-006229-7yoilsho	5026	13	the	the	DT
cord-006229-7yoilsho	5026	14	intravascular	intravascular	NN
cord-006229-7yoilsho	5026	15	from	from	IN
cord-006229-7yoilsho	5026	16	the	the	DT
cord-006229-7yoilsho	5026	17	interstitial	interstitial	JJ
cord-006229-7yoilsho	5026	18	compartment	compartment	NN
cord-006229-7yoilsho	5026	19	and	and	CC
cord-006229-7yoilsho	5026	20	thereby	thereby	RB
cord-006229-7yoilsho	5026	21	investigations	investigation	NNS
cord-006229-7yoilsho	5026	22	of	of	IN
cord-006229-7yoilsho	5026	23	changes	change	NNS
cord-006229-7yoilsho	5026	24	of	of	IN
cord-006229-7yoilsho	5026	25	the	the	DT
cord-006229-7yoilsho	5026	26	physiologic	physiologic	JJ
cord-006229-7yoilsho	5026	27	endothelial	endothelial	JJ
cord-006229-7yoilsho	5026	28	barrier	barrier	NN
cord-006229-7yoilsho	5026	29	induced	induce	VBN
cord-006229-7yoilsho	5026	30	by	by	IN
cord-006229-7yoilsho	5026	31	drugs	drug	NNS
cord-006229-7yoilsho	5026	32	or	or	CC
cord-006229-7yoilsho	5026	33	transgenes	transgene	NNS
cord-006229-7yoilsho	5026	34	.	.	.
cord-006229-7yoilsho	5027	1	Therefore	therefore	RB
cord-006229-7yoilsho	5027	2	,	,	,
cord-006229-7yoilsho	5027	3	we	-PRON-	PRP
cord-006229-7yoilsho	5027	4	have	have	VBP
cord-006229-7yoilsho	5027	5	evaluated	evaluate	VBN
cord-006229-7yoilsho	5027	6	this	this	DT
cord-006229-7yoilsho	5027	7	methodology	methodology	NN
cord-006229-7yoilsho	5027	8	for	for	IN
cord-006229-7yoilsho	5027	9	its	-PRON-	PRP$
cord-006229-7yoilsho	5027	10	suitability	suitability	NN
cord-006229-7yoilsho	5027	11	to	to	TO
cord-006229-7yoilsho	5027	12	study	study	VB
cord-006229-7yoilsho	5027	13	endothelial	endothelial	JJ
cord-006229-7yoilsho	5027	14	permeability	permeability	NN
cord-006229-7yoilsho	5027	15	in	in	IN
cord-006229-7yoilsho	5027	16	mice	mouse	NNS
cord-006229-7yoilsho	5027	17	in	in	IN
cord-006229-7yoilsho	5027	18	vivo	vivo	NNP
cord-006229-7yoilsho	5027	19	.	.	.
cord-006229-7yoilsho	5028	1	To	to	TO
cord-006229-7yoilsho	5028	2	establish	establish	VB
cord-006229-7yoilsho	5028	3	this	this	DT
cord-006229-7yoilsho	5028	4	,	,	,
cord-006229-7yoilsho	5028	5	we	-PRON-	PRP
cord-006229-7yoilsho	5028	6	used	use	VBD
cord-006229-7yoilsho	5028	7	two	two	CD
cord-006229-7yoilsho	5028	8	different	different	JJ
cord-006229-7yoilsho	5028	9	fluorescent	fluorescent	NN
cord-006229-7yoilsho	5028	10	dyes	dye	NNS
cord-006229-7yoilsho	5028	11	of	of	IN
cord-006229-7yoilsho	5028	12	different	different	JJ
cord-006229-7yoilsho	5028	13	molecular	molecular	JJ
cord-006229-7yoilsho	5028	14	weight	weight	NN
cord-006229-7yoilsho	5028	15	.	.	.
cord-006229-7yoilsho	5029	1	A	a	DT
cord-006229-7yoilsho	5029	2	200,000	200,000	CD
cord-006229-7yoilsho	5029	3	kDa	kDa	NNS
cord-006229-7yoilsho	5029	4	dextran	dextran	NN
cord-006229-7yoilsho	5029	5	equipped	equip	VBN
cord-006229-7yoilsho	5029	6	with	with	IN
cord-006229-7yoilsho	5029	7	a	a	DT
cord-006229-7yoilsho	5029	8	green	green	JJ
cord-006229-7yoilsho	5029	9	fluorescent	fluorescent	NN
cord-006229-7yoilsho	5029	10	chromophore	chromophore	NN
cord-006229-7yoilsho	5029	11	which	which	WDT
cord-006229-7yoilsho	5029	12	can	can	MD
cord-006229-7yoilsho	5029	13	not	not	RB
cord-006229-7yoilsho	5029	14	leave	leave	VB
cord-006229-7yoilsho	5029	15	vascular	vascular	JJ
cord-006229-7yoilsho	5029	16	lumen	lumen	NN
cord-006229-7yoilsho	5029	17	was	be	VBD
cord-006229-7yoilsho	5029	18	injected	inject	VBN
cord-006229-7yoilsho	5029	19	intravenously	intravenously	RB
cord-006229-7yoilsho	5029	20	to	to	TO
cord-006229-7yoilsho	5029	21	visualize	visualize	VB
cord-006229-7yoilsho	5029	22	small	small	JJ
cord-006229-7yoilsho	5029	23	dermal	dermal	JJ
cord-006229-7yoilsho	5029	24	blood	blood	NN
cord-006229-7yoilsho	5029	25	vessels	vessel	NNS
cord-006229-7yoilsho	5029	26	of	of	IN
cord-006229-7yoilsho	5029	27	the	the	DT
cord-006229-7yoilsho	5029	28	mouse	mouse	NN
cord-006229-7yoilsho	5029	29	ear	ear	NN
cord-006229-7yoilsho	5029	30	located	locate	VBN
cord-006229-7yoilsho	5029	31	approximately	approximately	RB
cord-006229-7yoilsho	5029	32	200	200	CD
cord-006229-7yoilsho	5029	33	µm	µm	NN
cord-006229-7yoilsho	5029	34	below	below	IN
cord-006229-7yoilsho	5029	35	the	the	DT
cord-006229-7yoilsho	5029	36	surface	surface	NN
cord-006229-7yoilsho	5029	37	.	.	.
cord-006229-7yoilsho	5030	1	After	after	IN
cord-006229-7yoilsho	5030	2	stabilization	stabilization	NN
cord-006229-7yoilsho	5030	3	of	of	IN
cord-006229-7yoilsho	5030	4	the	the	DT
cord-006229-7yoilsho	5030	5	green	green	JJ
cord-006229-7yoilsho	5030	6	fluorescent	fluorescent	NN
cord-006229-7yoilsho	5030	7	signal	signal	NN
cord-006229-7yoilsho	5030	8	,	,	,
cord-006229-7yoilsho	5030	9	a	a	DT
cord-006229-7yoilsho	5030	10	10,000	10,000	CD
cord-006229-7yoilsho	5030	11	kDa	kDa	NNS
cord-006229-7yoilsho	5030	12	dextran	dextran	NN
cord-006229-7yoilsho	5030	13	equipped	equip	VBN
cord-006229-7yoilsho	5030	14	with	with	IN
cord-006229-7yoilsho	5030	15	a	a	DT
cord-006229-7yoilsho	5030	16	red	red	JJ
cord-006229-7yoilsho	5030	17	fluorescent	fluorescent	NN
cord-006229-7yoilsho	5030	18	chromophore	chromophore	NN
cord-006229-7yoilsho	5030	19	which	which	WDT
cord-006229-7yoilsho	5030	20	easily	easily	RB
cord-006229-7yoilsho	5030	21	traverses	traverse	VBZ
cord-006229-7yoilsho	5030	22	the	the	DT
cord-006229-7yoilsho	5030	23	endothelial	endothelial	JJ
cord-006229-7yoilsho	5030	24	barrier	barrier	NN
cord-006229-7yoilsho	5030	25	was	be	VBD
cord-006229-7yoilsho	5030	26	applied	apply	VBN
cord-006229-7yoilsho	5030	27	by	by	IN
cord-006229-7yoilsho	5030	28	intravenous	intravenous	JJ
cord-006229-7yoilsho	5030	29	injection	injection	NN
cord-006229-7yoilsho	5030	30	.	.	.
cord-006229-7yoilsho	5031	1	The	the	DT
cord-006229-7yoilsho	5031	2	red	red	JJ
cord-006229-7yoilsho	5031	3	fluorescence	fluorescence	NN
cord-006229-7yoilsho	5031	4	permeates	permeate	VBZ
cord-006229-7yoilsho	5031	5	into	into	IN
cord-006229-7yoilsho	5031	6	the	the	DT
cord-006229-7yoilsho	5031	7	interstitium	interstitium	NN
cord-006229-7yoilsho	5031	8	during	during	IN
cord-006229-7yoilsho	5031	9	physiologic	physiologic	JJ
cord-006229-7yoilsho	5031	10	extravasation	extravasation	NN
cord-006229-7yoilsho	5031	11	and	and	CC
cord-006229-7yoilsho	5031	12	accumulates	accumulate	VBZ
cord-006229-7yoilsho	5031	13	in	in	IN
cord-006229-7yoilsho	5031	14	the	the	DT
cord-006229-7yoilsho	5031	15	interstitial	interstitial	JJ
cord-006229-7yoilsho	5031	16	space	space	NN
cord-006229-7yoilsho	5031	17	.	.	.
cord-006229-7yoilsho	5032	1	This	this	DT
cord-006229-7yoilsho	5032	2	process	process	NN
cord-006229-7yoilsho	5032	3	can	can	MD
cord-006229-7yoilsho	5032	4	be	be	VB
cord-006229-7yoilsho	5032	5	followed	follow	VBN
cord-006229-7yoilsho	5032	6	by	by	IN
cord-006229-7yoilsho	5032	7	measuring	measure	VBG
cord-006229-7yoilsho	5032	8	the	the	DT
cord-006229-7yoilsho	5032	9	decrease	decrease	NN
cord-006229-7yoilsho	5032	10	of	of	IN
cord-006229-7yoilsho	5032	11	intravascular	intravascular	JJ
cord-006229-7yoilsho	5032	12	red	red	JJ
cord-006229-7yoilsho	5032	13	fluorescence	fluorescence	NN
cord-006229-7yoilsho	5032	14	over	over	IN
cord-006229-7yoilsho	5032	15	various	various	JJ
cord-006229-7yoilsho	5032	16	time	time	NN
cord-006229-7yoilsho	5032	17	periods	period	NNS
cord-006229-7yoilsho	5032	18	.	.	.
cord-006229-7yoilsho	5033	1	Using	use	VBG
cord-006229-7yoilsho	5033	2	this	this	DT
cord-006229-7yoilsho	5033	3	methodology	methodology	NN
cord-006229-7yoilsho	5033	4	we	-PRON-	PRP
cord-006229-7yoilsho	5033	5	have	have	VBP
cord-006229-7yoilsho	5033	6	studied	study	VBN
cord-006229-7yoilsho	5033	7	whether	whether	IN
cord-006229-7yoilsho	5033	8	endothelial	endothelial	RB
cord-006229-7yoilsho	5033	9	-	-	HYPH
cord-006229-7yoilsho	5033	10	specific	specific	JJ
cord-006229-7yoilsho	5033	11	overexpression	overexpression	NN
cord-006229-7yoilsho	5033	12	of	of	IN
cord-006229-7yoilsho	5033	13	B2	b2	NN
cord-006229-7yoilsho	5033	14	changes	change	VBZ
cord-006229-7yoilsho	5033	15	physiologic	physiologic	JJ
cord-006229-7yoilsho	5033	16	endothelial	endothelial	JJ
cord-006229-7yoilsho	5033	17	permeability	permeability	NN
cord-006229-7yoilsho	5033	18	.	.	.
cord-006229-7yoilsho	5034	1	This	this	DT
cord-006229-7yoilsho	5034	2	newly	newly	RB
cord-006229-7yoilsho	5034	3	developed	develop	VBN
cord-006229-7yoilsho	5034	4	transgenic	transgenic	JJ
cord-006229-7yoilsho	5034	5	mouse	mouse	NN
cord-006229-7yoilsho	5034	6	line	line	NN
cord-006229-7yoilsho	5034	7	(	(	-LRB-
cord-006229-7yoilsho	5034	8	B2	B2	NNP
cord-006229-7yoilsho	5034	9	tg	tg	NNP
cord-006229-7yoilsho	5034	10	)	)	-RRB-
cord-006229-7yoilsho	5034	11	was	be	VBD
cord-006229-7yoilsho	5034	12	established	establish	VBN
cord-006229-7yoilsho	5034	13	using	use	VBG
cord-006229-7yoilsho	5034	14	a	a	DT
cord-006229-7yoilsho	5034	15	plasmid	plasmid	NN
cord-006229-7yoilsho	5034	16	consisting	consist	VBG
cord-006229-7yoilsho	5034	17	of	of	IN
cord-006229-7yoilsho	5034	18	pBluescript	pBluescript	NNP
cord-006229-7yoilsho	5034	19	II	II	NNP
cord-006229-7yoilsho	5034	20	SK+	SK+	NNP
cord-006229-7yoilsho	5034	21	-Vector	-Vector	NNP
cord-006229-7yoilsho	5034	22	,	,	,
cord-006229-7yoilsho	5034	23	the	the	DT
cord-006229-7yoilsho	5034	24	Tie-2-promotor	Tie-2-promotor	NNP
cord-006229-7yoilsho	5034	25	,	,	,
cord-006229-7yoilsho	5034	26	the	the	DT
cord-006229-7yoilsho	5034	27	human	human	JJ
cord-006229-7yoilsho	5034	28	B2	B2	NNP
cord-006229-7yoilsho	5034	29	cDNA	cdna	NN
cord-006229-7yoilsho	5034	30	,	,	,
cord-006229-7yoilsho	5034	31	the	the	DT
cord-006229-7yoilsho	5034	32	SV40	SV40	NNP
cord-006229-7yoilsho	5034	33	poly	poly	NN
cord-006229-7yoilsho	5034	34	-	-	HYPH
cord-006229-7yoilsho	5034	35	A	a	NN
cord-006229-7yoilsho	5034	36	-	-	HYPH
cord-006229-7yoilsho	5034	37	signal	signal	NN
cord-006229-7yoilsho	5034	38	and	and	CC
cord-006229-7yoilsho	5034	39	a	a	DT
cord-006229-7yoilsho	5034	40	Tie-2	Tie-2	NNP
cord-006229-7yoilsho	5034	41	intron	intron	NN
cord-006229-7yoilsho	5034	42	fragment	fragment	NN
cord-006229-7yoilsho	5034	43	.	.	.
cord-006229-7yoilsho	5035	1	We	-PRON-	PRP
cord-006229-7yoilsho	5035	2	observed	observe	VBD
cord-006229-7yoilsho	5035	3	that	that	IN
cord-006229-7yoilsho	5035	4	B2tg	B2tg	NNP
cord-006229-7yoilsho	5035	5	showed	show	VBD
cord-006229-7yoilsho	5035	6	a	a	DT
cord-006229-7yoilsho	5035	7	significantly	significantly	RB
cord-006229-7yoilsho	5035	8	stronger	strong	JJR
cord-006229-7yoilsho	5035	9	extravasation	extravasation	NN
cord-006229-7yoilsho	5035	10	than	than	IN
cord-006229-7yoilsho	5035	11	their	-PRON-	PRP$
cord-006229-7yoilsho	5035	12	transgene	transgene	NN
cord-006229-7yoilsho	5035	13	negative	negative	JJ
cord-006229-7yoilsho	5035	14	littermates	littermate	NNS
cord-006229-7yoilsho	5035	15	as	as	IN
cord-006229-7yoilsho	5035	16	evidenced	evidence	VBN
cord-006229-7yoilsho	5035	17	by	by	IN
cord-006229-7yoilsho	5035	18	the	the	DT
cord-006229-7yoilsho	5035	19	more	more	RBR
cord-006229-7yoilsho	5035	20	rapid	rapid	JJ
cord-006229-7yoilsho	5035	21	extravasation	extravasation	NN
cord-006229-7yoilsho	5035	22	of	of	IN
cord-006229-7yoilsho	5035	23	the	the	DT
cord-006229-7yoilsho	5035	24	10,000	10,000	CD
cord-006229-7yoilsho	5035	25	kDa	kDa	NNS
cord-006229-7yoilsho	5035	26	dextran	dextran	NN
cord-006229-7yoilsho	5035	27	at	at	IN
cord-006229-7yoilsho	5035	28	each	each	DT
cord-006229-7yoilsho	5035	29	time	time	NN
cord-006229-7yoilsho	5035	30	point	point	NN
cord-006229-7yoilsho	5035	31	(	(	-LRB-
cord-006229-7yoilsho	5035	32	Fig	Fig	NNP
cord-006229-7yoilsho	5035	33	.	.	.
cord-006229-7yoilsho	5035	34	1	1	CD
cord-006229-7yoilsho	5035	35	)	)	-RRB-
cord-006229-7yoilsho	5035	36	.We	.We	.
cord-006229-7yoilsho	5036	1	conclude	conclude	VB
cord-006229-7yoilsho	5036	2	that	that	IN
cord-006229-7yoilsho	5036	3	two	two	CD
cord-006229-7yoilsho	5036	4	-	-	HYPH
cord-006229-7yoilsho	5036	5	photon	photon	NN
cord-006229-7yoilsho	5036	6	laser	laser	NN
cord-006229-7yoilsho	5036	7	microscopy	microscopy	NN
cord-006229-7yoilsho	5036	8	is	be	VBZ
cord-006229-7yoilsho	5036	9	suitable	suitable	JJ
cord-006229-7yoilsho	5036	10	to	to	TO
cord-006229-7yoilsho	5036	11	study	study	VB
cord-006229-7yoilsho	5036	12	endothelial	endothelial	JJ
cord-006229-7yoilsho	5036	13	permeability	permeability	NN
cord-006229-7yoilsho	5036	14	non	non	JJ
cord-006229-7yoilsho	5036	15	-	-	VBZ
cord-006229-7yoilsho	5036	16	invasively	invasively	RB
cord-006229-7yoilsho	5036	17	in	in	IN
cord-006229-7yoilsho	5036	18	-	-	HYPH
cord-006229-7yoilsho	5036	19	vivo	vivo	NN
cord-006229-7yoilsho	5036	20	and	and	CC
cord-006229-7yoilsho	5036	21	that	that	IN
cord-006229-7yoilsho	5036	22	this	this	DT
cord-006229-7yoilsho	5036	23	methodology	methodology	NN
cord-006229-7yoilsho	5036	24	allows	allow	VBZ
cord-006229-7yoilsho	5036	25	to	to	TO
cord-006229-7yoilsho	5036	26	study	study	VB
cord-006229-7yoilsho	5036	27	the	the	DT
cord-006229-7yoilsho	5036	28	effects	effect	NNS
cord-006229-7yoilsho	5036	29	of	of	IN
cord-006229-7yoilsho	5036	30	drugs	drug	NNS
cord-006229-7yoilsho	5036	31	and	and	CC
cord-006229-7yoilsho	5036	32	transgenes	transgene	NNS
cord-006229-7yoilsho	5036	33	on	on	IN
cord-006229-7yoilsho	5036	34	the	the	DT
cord-006229-7yoilsho	5036	35	endothelial	endothelial	JJ
cord-006229-7yoilsho	5036	36	barrier	barrier	NN
cord-006229-7yoilsho	5036	37	under	under	IN
cord-006229-7yoilsho	5036	38	non	non	JJ
cord-006229-7yoilsho	5036	39	-	-	JJ
cord-006229-7yoilsho	5036	40	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	5036	41	conditions	condition	NNS
cord-006229-7yoilsho	5036	42	.	.	.
cord-006229-7yoilsho	5037	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	5037	2	,	,	,
cord-006229-7yoilsho	5037	3	our	-PRON-	PRP$
cord-006229-7yoilsho	5037	4	results	result	NNS
cord-006229-7yoilsho	5037	5	suggest	suggest	VBP
cord-006229-7yoilsho	5037	6	that	that	IN
cord-006229-7yoilsho	5037	7	endothelial	endothelial	RB
cord-006229-7yoilsho	5037	8	-	-	HYPH
cord-006229-7yoilsho	5037	9	specific	specific	JJ
cord-006229-7yoilsho	5037	10	overexpression	overexpression	NN
cord-006229-7yoilsho	5037	11	of	of	IN
cord-006229-7yoilsho	5037	12	B2	b2	NN
cord-006229-7yoilsho	5037	13	increases	increase	VBZ
cord-006229-7yoilsho	5037	14	physiologic	physiologic	JJ
cord-006229-7yoilsho	5037	15	extravasation	extravasation	NN
cord-006229-7yoilsho	5037	16	.	.	.
cord-006229-7yoilsho	5038	1	Non	non	JJ
cord-006229-7yoilsho	5038	2	-	-	JJ
cord-006229-7yoilsho	5038	3	allergic	allergic	JJ
cord-006229-7yoilsho	5038	4	angioedema	angioedema	NN
cord-006229-7yoilsho	5038	5	such	such	JJ
cord-006229-7yoilsho	5038	6	as	as	IN
cord-006229-7yoilsho	5038	7	angioedema	angioedema	NN
cord-006229-7yoilsho	5038	8	induced	induce	VBN
cord-006229-7yoilsho	5038	9	by	by	IN
cord-006229-7yoilsho	5038	10	angiotensin	angiotensin	NN
cord-006229-7yoilsho	5038	11	converting	convert	VBG
cord-006229-7yoilsho	5038	12	enzyme	enzyme	NN
cord-006229-7yoilsho	5038	13	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	5038	14	(	(	-LRB-
cord-006229-7yoilsho	5038	15	ACEi	ACEi	NNP
cord-006229-7yoilsho	5038	16	)	)	-RRB-
cord-006229-7yoilsho	5038	17	develops	develop	VBZ
cord-006229-7yoilsho	5038	18	as	as	IN
cord-006229-7yoilsho	5038	19	a	a	DT
cord-006229-7yoilsho	5038	20	consequence	consequence	NN
cord-006229-7yoilsho	5038	21	of	of	IN
cord-006229-7yoilsho	5038	22	increased	increase	VBN
cord-006229-7yoilsho	5038	23	activation	activation	NN
cord-006229-7yoilsho	5038	24	of	of	IN
cord-006229-7yoilsho	5038	25	bradykinin	bradykinin	NN
cord-006229-7yoilsho	5038	26	receptor	receptor	NN
cord-006229-7yoilsho	5038	27	type	type	NN
cord-006229-7yoilsho	5038	28	2	2	CD
cord-006229-7yoilsho	5038	29	(	(	-LRB-
cord-006229-7yoilsho	5038	30	B2	b2	NN
cord-006229-7yoilsho	5038	31	)	)	-RRB-
cord-006229-7yoilsho	5038	32	.	.	.
cord-006229-7yoilsho	5039	1	Using	use	VBG
cord-006229-7yoilsho	5039	2	a	a	DT
cord-006229-7yoilsho	5039	3	plasmid	plasmid	NN
cord-006229-7yoilsho	5039	4	consisting	consist	VBG
cord-006229-7yoilsho	5039	5	of	of	IN
cord-006229-7yoilsho	5039	6	pBluescript	pBluescript	NNP
cord-006229-7yoilsho	5039	7	II	II	NNP
cord-006229-7yoilsho	5039	8	SK+	SK+	NNP
cord-006229-7yoilsho	5039	9	-Vector	-Vector	NNP
cord-006229-7yoilsho	5039	10	,	,	,
cord-006229-7yoilsho	5039	11	the	the	DT
cord-006229-7yoilsho	5039	12	Tie-2-promotor	Tie-2-promotor	NNP
cord-006229-7yoilsho	5039	13	,	,	,
cord-006229-7yoilsho	5039	14	the	the	DT
cord-006229-7yoilsho	5039	15	human	human	JJ
cord-006229-7yoilsho	5039	16	B2	B2	NNP
cord-006229-7yoilsho	5039	17	cDNA	cdna	NN
cord-006229-7yoilsho	5039	18	,	,	,
cord-006229-7yoilsho	5039	19	the	the	DT
cord-006229-7yoilsho	5039	20	SV40	SV40	NNP
cord-006229-7yoilsho	5039	21	poly	poly	NN
cord-006229-7yoilsho	5039	22	-	-	HYPH
cord-006229-7yoilsho	5039	23	A	a	NN
cord-006229-7yoilsho	5039	24	-	-	HYPH
cord-006229-7yoilsho	5039	25	signal	signal	NN
cord-006229-7yoilsho	5039	26	and	and	CC
cord-006229-7yoilsho	5039	27	a	a	DT
cord-006229-7yoilsho	5039	28	Tie-2	Tie-2	NNP
cord-006229-7yoilsho	5039	29	intron	intron	NN
cord-006229-7yoilsho	5039	30	fragment	fragment	NN
cord-006229-7yoilsho	5039	31	a	a	DT
cord-006229-7yoilsho	5039	32	transgenic	transgenic	JJ
cord-006229-7yoilsho	5039	33	mouse	mouse	NN
cord-006229-7yoilsho	5039	34	line	line	NN
cord-006229-7yoilsho	5039	35	harbouring	harbour	VBG
cord-006229-7yoilsho	5039	36	an	an	DT
cord-006229-7yoilsho	5039	37	endothelial	endothelial	RB
cord-006229-7yoilsho	5039	38	-	-	HYPH
cord-006229-7yoilsho	5039	39	specific	specific	JJ
cord-006229-7yoilsho	5039	40	overexpression	overexpression	NN
cord-006229-7yoilsho	5039	41	of	of	IN
cord-006229-7yoilsho	5039	42	B2	b2	NN
cord-006229-7yoilsho	5039	43	was	be	VBD
cord-006229-7yoilsho	5039	44	generated	generate	VBN
cord-006229-7yoilsho	5039	45	and	and	CC
cord-006229-7yoilsho	5039	46	backcrossed	backcross	VBN
cord-006229-7yoilsho	5039	47	to	to	IN
cord-006229-7yoilsho	5039	48	C57BL/6	C57BL/6	NNP
cord-006229-7yoilsho	5039	49	for	for	IN
cord-006229-7yoilsho	5039	50	more	more	JJR
cord-006229-7yoilsho	5039	51	than	than	IN
cord-006229-7yoilsho	5039	52	10	10	CD
cord-006229-7yoilsho	5039	53	times	time	NNS
cord-006229-7yoilsho	5039	54	(	(	-LRB-
cord-006229-7yoilsho	5039	55	B2	B2	NNP
cord-006229-7yoilsho	5039	56	tg	tg	NNP
cord-006229-7yoilsho	5039	57	)	)	-RRB-
cord-006229-7yoilsho	5039	58	.	.	.
cord-006229-7yoilsho	5040	1	Lung	Lung	NNP
cord-006229-7yoilsho	5040	2	mRNA	mrna	NN
cord-006229-7yoilsho	5040	3	using	use	VBG
cord-006229-7yoilsho	5040	4	primers	primer	NNS
cord-006229-7yoilsho	5040	5	specific	specific	JJ
cord-006229-7yoilsho	5040	6	for	for	IN
cord-006229-7yoilsho	5040	7	the	the	DT
cord-006229-7yoilsho	5040	8	human	human	NN
cord-006229-7yoilsho	5040	9	or	or	CC
cord-006229-7yoilsho	5040	10	the	the	DT
cord-006229-7yoilsho	5040	11	mouse	mouse	NN
cord-006229-7yoilsho	5040	12	B2	B2	NNP
cord-006229-7yoilsho	5040	13	cDNA	cDNA	NNP
cord-006229-7yoilsho	5040	14	revealed	reveal	VBD
cord-006229-7yoilsho	5040	15	a	a	DT
cord-006229-7yoilsho	5040	16	12.5-fold	12.5-fold	CD
cord-006229-7yoilsho	5040	17	stronger	strong	JJR
cord-006229-7yoilsho	5040	18	expression	expression	NN
cord-006229-7yoilsho	5040	19	of	of	IN
cord-006229-7yoilsho	5040	20	human	human	JJ
cord-006229-7yoilsho	5040	21	B2	b2	NN
cord-006229-7yoilsho	5040	22	in	in	IN
cord-006229-7yoilsho	5040	23	B2	B2	NNP
cord-006229-7yoilsho	5040	24	tg	tg	NNP
cord-006229-7yoilsho	5040	25	(	(	-LRB-
cord-006229-7yoilsho	5040	26	n=6	n=6	NNP
cord-006229-7yoilsho	5040	27	)	)	-RRB-
cord-006229-7yoilsho	5040	28	,	,	,
cord-006229-7yoilsho	5040	29	while	while	IN
cord-006229-7yoilsho	5040	30	the	the	DT
cord-006229-7yoilsho	5040	31	expression	expression	NN
cord-006229-7yoilsho	5040	32	of	of	IN
cord-006229-7yoilsho	5040	33	murine	murine	JJ
cord-006229-7yoilsho	5040	34	B2	B2	NNP
cord-006229-7yoilsho	5040	35	mRNA	mRNA	NNP
cord-006229-7yoilsho	5040	36	was	be	VBD
cord-006229-7yoilsho	5040	37	unchanged	unchanged	JJ
cord-006229-7yoilsho	5040	38	and	and	CC
cord-006229-7yoilsho	5040	39	similar	similar	JJ
cord-006229-7yoilsho	5040	40	to	to	TO
cord-006229-7yoilsho	5040	41	transgene	transgene	JJ
cord-006229-7yoilsho	5040	42	negative	negative	JJ
cord-006229-7yoilsho	5040	43	littermates	littermate	NNS
cord-006229-7yoilsho	5040	44	(	(	-LRB-
cord-006229-7yoilsho	5040	45	B2	b2	NN
cord-006229-7yoilsho	5040	46	n	n	NNP
cord-006229-7yoilsho	5040	47	)	)	-RRB-
cord-006229-7yoilsho	5040	48	.	.	.
cord-006229-7yoilsho	5041	1	We	-PRON-	PRP
cord-006229-7yoilsho	5041	2	have	have	VBP
cord-006229-7yoilsho	5041	3	evaluated	evaluate	VBN
cord-006229-7yoilsho	5041	4	the	the	DT
cord-006229-7yoilsho	5041	5	specificity	specificity	NN
cord-006229-7yoilsho	5041	6	of	of	IN
cord-006229-7yoilsho	5041	7	several	several	JJ
cord-006229-7yoilsho	5041	8	antibodies	antibody	NNS
cord-006229-7yoilsho	5041	9	directed	direct	VBN
cord-006229-7yoilsho	5041	10	against	against	IN
cord-006229-7yoilsho	5041	11	B2	b2	NN
cord-006229-7yoilsho	5041	12	and	and	CC
cord-006229-7yoilsho	5041	13	found	find	VBD
cord-006229-7yoilsho	5041	14	that	that	IN
cord-006229-7yoilsho	5041	15	a	a	DT
cord-006229-7yoilsho	5041	16	rabbit	rabbit	NN
cord-006229-7yoilsho	5041	17	monoclonal	monoclonal	JJ
cord-006229-7yoilsho	5041	18	anti	anti	NNP
cord-006229-7yoilsho	5041	19	B2	B2	NNP
cord-006229-7yoilsho	5041	20	antibody	antibody	NN
cord-006229-7yoilsho	5041	21	appears	appear	VBZ
cord-006229-7yoilsho	5041	22	to	to	TO
cord-006229-7yoilsho	5041	23	be	be	VB
cord-006229-7yoilsho	5041	24	reliable	reliable	JJ
cord-006229-7yoilsho	5041	25	,	,	,
cord-006229-7yoilsho	5041	26	i.e.	i.e.	FW
cord-006229-7yoilsho	5041	27	there	there	EX
cord-006229-7yoilsho	5041	28	was	be	VBD
cord-006229-7yoilsho	5041	29	just	just	RB
cord-006229-7yoilsho	5041	30	a	a	DT
cord-006229-7yoilsho	5041	31	faint	faint	JJ
cord-006229-7yoilsho	5041	32	staining	staining	NN
cord-006229-7yoilsho	5041	33	in	in	IN
cord-006229-7yoilsho	5041	34	lung	lung	NN
cord-006229-7yoilsho	5041	35	tissue	tissue	NN
cord-006229-7yoilsho	5041	36	of	of	IN
cord-006229-7yoilsho	5041	37	B2	b2	NN
cord-006229-7yoilsho	5041	38	-/mice	-/mice	NNP
cord-006229-7yoilsho	5041	39	.	.	.
cord-006229-7yoilsho	5042	1	However	however	RB
cord-006229-7yoilsho	5042	2	,	,	,
cord-006229-7yoilsho	5042	3	this	this	DT
cord-006229-7yoilsho	5042	4	antibody	antibody	NN
cord-006229-7yoilsho	5042	5	primarily	primarily	RB
cord-006229-7yoilsho	5042	6	stains	stain	VBZ
cord-006229-7yoilsho	5042	7	rodent	rodent	NN
cord-006229-7yoilsho	5042	8	B2	b2	NN
cord-006229-7yoilsho	5042	9	and	and	CC
cord-006229-7yoilsho	5042	10	has	have	VBZ
cord-006229-7yoilsho	5042	11	only	only	RB
cord-006229-7yoilsho	5042	12	little	little	JJ
cord-006229-7yoilsho	5042	13	cross	cross	NN
cord-006229-7yoilsho	5042	14	-	-	NN
cord-006229-7yoilsho	5042	15	reactivity	reactivity	NN
cord-006229-7yoilsho	5042	16	to	to	IN
cord-006229-7yoilsho	5042	17	human	human	JJ
cord-006229-7yoilsho	5042	18	B2	b2	NN
cord-006229-7yoilsho	5042	19	.	.	.
cord-006229-7yoilsho	5043	1	Hence	hence	RB
cord-006229-7yoilsho	5043	2	,	,	,
cord-006229-7yoilsho	5043	3	we	-PRON-	PRP
cord-006229-7yoilsho	5043	4	were	be	VBD
cord-006229-7yoilsho	5043	5	not	not	RB
cord-006229-7yoilsho	5043	6	able	able	JJ
cord-006229-7yoilsho	5043	7	to	to	TO
cord-006229-7yoilsho	5043	8	detect	detect	VB
cord-006229-7yoilsho	5043	9	a	a	DT
cord-006229-7yoilsho	5043	10	significant	significant	JJ
cord-006229-7yoilsho	5043	11	increase	increase	NN
cord-006229-7yoilsho	5043	12	of	of	IN
cord-006229-7yoilsho	5043	13	B2	b2	NN
cord-006229-7yoilsho	5043	14	protein	protein	NN
cord-006229-7yoilsho	5043	15	in	in	IN
cord-006229-7yoilsho	5043	16	tissues	tissue	NNS
cord-006229-7yoilsho	5043	17	of	of	IN
cord-006229-7yoilsho	5043	18	B2	B2	NNP
cord-006229-7yoilsho	5043	19	tg	tg	NNP
cord-006229-7yoilsho	5043	20	.	.	.
cord-006229-7yoilsho	5044	1	Previous	previous	JJ
cord-006229-7yoilsho	5044	2	experiments	experiment	NNS
cord-006229-7yoilsho	5044	3	have	have	VBP
cord-006229-7yoilsho	5044	4	shown	show	VBN
cord-006229-7yoilsho	5044	5	that	that	IN
cord-006229-7yoilsho	5044	6	bradykinin	bradykinin	NN
cord-006229-7yoilsho	5044	7	induced	induce	VBN
cord-006229-7yoilsho	5044	8	concentration	concentration	NN
cord-006229-7yoilsho	5044	9	-	-	HYPH
cord-006229-7yoilsho	5044	10	dependent	dependent	JJ
cord-006229-7yoilsho	5044	11	constrictions	constriction	NNS
cord-006229-7yoilsho	5044	12	of	of	IN
cord-006229-7yoilsho	5044	13	aortic	aortic	JJ
cord-006229-7yoilsho	5044	14	rings	ring	NNS
cord-006229-7yoilsho	5044	15	with	with	IN
cord-006229-7yoilsho	5044	16	a	a	DT
cord-006229-7yoilsho	5044	17	maximal	maximal	JJ
cord-006229-7yoilsho	5044	18	effect	effect	NN
cord-006229-7yoilsho	5044	19	at	at	IN
cord-006229-7yoilsho	5044	20	1	1	CD
cord-006229-7yoilsho	5044	21	µM	µm	CD
cord-006229-7yoilsho	5044	22	of	of	IN
cord-006229-7yoilsho	5044	23	bradykinin	bradykinin	NN
cord-006229-7yoilsho	5044	24	.	.	.
cord-006229-7yoilsho	5045	1	The	the	DT
cord-006229-7yoilsho	5045	2	contraction	contraction	NN
cord-006229-7yoilsho	5045	3	due	due	IN
cord-006229-7yoilsho	5045	4	to	to	IN
cord-006229-7yoilsho	5045	5	bradykinin	bradykinin	NN
cord-006229-7yoilsho	5045	6	was	be	VBD
cord-006229-7yoilsho	5045	7	completely	completely	RB
cord-006229-7yoilsho	5045	8	inhibited	inhibit	VBN
cord-006229-7yoilsho	5045	9	by	by	IN
cord-006229-7yoilsho	5045	10	icatibant	icatibant	JJ
cord-006229-7yoilsho	5045	11	or	or	CC
cord-006229-7yoilsho	5045	12	diclofenac	diclofenac	JJ
cord-006229-7yoilsho	5045	13	indicating	indicate	VBG
cord-006229-7yoilsho	5045	14	that	that	IN
cord-006229-7yoilsho	5045	15	it	-PRON-	PRP
cord-006229-7yoilsho	5045	16	is	be	VBZ
cord-006229-7yoilsho	5045	17	mediated	mediate	VBN
cord-006229-7yoilsho	5045	18	by	by	IN
cord-006229-7yoilsho	5045	19	endothelial	endothelial	JJ
cord-006229-7yoilsho	5045	20	B2	b2	NN
cord-006229-7yoilsho	5045	21	activation	activation	NN
cord-006229-7yoilsho	5045	22	and	and	CC
cord-006229-7yoilsho	5045	23	dependent	dependent	JJ
cord-006229-7yoilsho	5045	24	on	on	IN
cord-006229-7yoilsho	5045	25	cyclooxygenase	cyclooxygenase	JJ
cord-006229-7yoilsho	5045	26	activity	activity	NN
cord-006229-7yoilsho	5045	27	.	.	.
cord-006229-7yoilsho	5046	1	In	in	IN
cord-006229-7yoilsho	5046	2	striking	striking	JJ
cord-006229-7yoilsho	5046	3	contrast	contrast	NN
cord-006229-7yoilsho	5046	4	to	to	IN
cord-006229-7yoilsho	5046	5	their	-PRON-	PRP$
cord-006229-7yoilsho	5046	6	transgene	transgene	NN
cord-006229-7yoilsho	5046	7	negative	negative	JJ
cord-006229-7yoilsho	5046	8	littermates	littermate	NNS
cord-006229-7yoilsho	5047	1	B2	B2	NNP
cord-006229-7yoilsho	5047	2	n	n	NNP
cord-006229-7yoilsho	5048	1	,	,	,
cord-006229-7yoilsho	5048	2	we	-PRON-	PRP
cord-006229-7yoilsho	5048	3	found	find	VBD
cord-006229-7yoilsho	5048	4	a	a	DT
cord-006229-7yoilsho	5048	5	significant	significant	JJ
cord-006229-7yoilsho	5048	6	icatibant	icatibant	JJ
cord-006229-7yoilsho	5048	7	sensitive	sensitive	JJ
cord-006229-7yoilsho	5048	8	aortic	aortic	JJ
cord-006229-7yoilsho	5048	9	dilation	dilation	NN
cord-006229-7yoilsho	5048	10	in	in	IN
cord-006229-7yoilsho	5048	11	B2	B2	NNP
cord-006229-7yoilsho	5048	12	tg	tg	NNP
cord-006229-7yoilsho	5048	13	following	follow	VBG
cord-006229-7yoilsho	5048	14	preincubation	preincubation	NN
cord-006229-7yoilsho	5048	15	with	with	IN
cord-006229-7yoilsho	5048	16	diclofenac	diclofenac	NNP
cord-006229-7yoilsho	5048	17	which	which	WDT
cord-006229-7yoilsho	5048	18	indicates	indicate	VBZ
cord-006229-7yoilsho	5048	19	functional	functional	JJ
cord-006229-7yoilsho	5048	20	overexpression	overexpression	NN
cord-006229-7yoilsho	5048	21	of	of	IN
cord-006229-7yoilsho	5048	22	B2	b2	NN
cord-006229-7yoilsho	5048	23	in	in	IN
cord-006229-7yoilsho	5048	24	conductance	conductance	NN
cord-006229-7yoilsho	5048	25	vessels	vessel	NNS
cord-006229-7yoilsho	5048	26	of	of	IN
cord-006229-7yoilsho	5048	27	B2	B2	NNP
cord-006229-7yoilsho	5048	28	tg	tg	NNP
cord-006229-7yoilsho	5048	29	.	.	.
cord-006229-7yoilsho	5049	1	To	to	TO
cord-006229-7yoilsho	5049	2	evaluate	evaluate	VB
cord-006229-7yoilsho	5049	3	whether	whether	IN
cord-006229-7yoilsho	5049	4	this	this	DT
cord-006229-7yoilsho	5049	5	applies	apply	VBZ
cord-006229-7yoilsho	5049	6	to	to	IN
cord-006229-7yoilsho	5049	7	dermal	dermal	JJ
cord-006229-7yoilsho	5049	8	micro	micro	JJ
cord-006229-7yoilsho	5049	9	vessels	vessel	NNS
cord-006229-7yoilsho	5049	10	we	-PRON-	PRP
cord-006229-7yoilsho	5049	11	used	use	VBD
cord-006229-7yoilsho	5049	12	the	the	DT
cord-006229-7yoilsho	5049	13	Miles	Miles	NNP
cord-006229-7yoilsho	5049	14	assay	assay	NN
cord-006229-7yoilsho	5049	15	to	to	TO
cord-006229-7yoilsho	5049	16	quantify	quantify	VB
cord-006229-7yoilsho	5049	17	dermal	dermal	JJ
cord-006229-7yoilsho	5049	18	extravasation	extravasation	NN
cord-006229-7yoilsho	5049	19	of	of	IN
cord-006229-7yoilsho	5049	20	the	the	DT
cord-006229-7yoilsho	5049	21	albumin	albumin	NN
cord-006229-7yoilsho	5049	22	-	-	HYPH
cord-006229-7yoilsho	5049	23	bound	bind	VBN
cord-006229-7yoilsho	5049	24	dye	dye	NN
cord-006229-7yoilsho	5049	25	evans	evans	NNP
cord-006229-7yoilsho	5049	26	blue	blue	NNP
cord-006229-7yoilsho	5049	27	following	follow	VBG
cord-006229-7yoilsho	5049	28	intradermal	intradermal	JJ
cord-006229-7yoilsho	5049	29	injection	injection	NN
cord-006229-7yoilsho	5049	30	of	of	IN
cord-006229-7yoilsho	5049	31	30	30	CD
cord-006229-7yoilsho	5049	32	µl	µl	IN
cord-006229-7yoilsho	5049	33	of	of	IN
cord-006229-7yoilsho	5049	34	either	either	DT
cord-006229-7yoilsho	5049	35	vehicle	vehicle	NN
cord-006229-7yoilsho	5049	36	,	,	,
cord-006229-7yoilsho	5049	37	bradykinin	bradykinin	NN
cord-006229-7yoilsho	5049	38	,	,	,
cord-006229-7yoilsho	5049	39	labradimil	labradimil	NN
cord-006229-7yoilsho	5049	40	and	and	CC
cord-006229-7yoilsho	5049	41	histamine	histamine	NN
cord-006229-7yoilsho	5049	42	(	(	-LRB-
cord-006229-7yoilsho	5049	43	control	control	NN
cord-006229-7yoilsho	5049	44	)	)	-RRB-
cord-006229-7yoilsho	5049	45	.	.	.
cord-006229-7yoilsho	5050	1	Increasing	increase	VBG
cord-006229-7yoilsho	5050	2	concentrations	concentration	NNS
cord-006229-7yoilsho	5050	3	of	of	IN
cord-006229-7yoilsho	5050	4	bradykinin	bradykinin	NN
cord-006229-7yoilsho	5050	5	caused	cause	VBD
cord-006229-7yoilsho	5050	6	a	a	DT
cord-006229-7yoilsho	5050	7	significant	significant	JJ
cord-006229-7yoilsho	5050	8	increase	increase	NN
cord-006229-7yoilsho	5050	9	of	of	IN
cord-006229-7yoilsho	5050	10	extravasation	extravasation	NN
cord-006229-7yoilsho	5050	11	reaching	reach	VBG
cord-006229-7yoilsho	5050	12	4.41±0.11	4.41±0.11	CD
cord-006229-7yoilsho	5050	13	fold	fold	RB
cord-006229-7yoilsho	5050	14	at	at	IN
cord-006229-7yoilsho	5050	15	18.9	18.9	CD
cord-006229-7yoilsho	5050	16	nmol	nmol	JJ
cord-006229-7yoilsho	5050	17	bradykinin	bradykinin	NN
cord-006229-7yoilsho	5050	18	in	in	IN
cord-006229-7yoilsho	5050	19	C57BL/6	C57BL/6	NNP
cord-006229-7yoilsho	5051	1	(	(	-LRB-
cord-006229-7yoilsho	5051	2	n=6	n=6	UH
cord-006229-7yoilsho	5051	3	each	each	DT
cord-006229-7yoilsho	5051	4	,	,	,
cord-006229-7yoilsho	5051	5	P<0.0001	p<0.0001	JJ
cord-006229-7yoilsho	5051	6	vs.	vs.	IN
cord-006229-7yoilsho	5051	7	vehicle	vehicle	NN
cord-006229-7yoilsho	5051	8	)	)	-RRB-
cord-006229-7yoilsho	5051	9	.	.	.
cord-006229-7yoilsho	5052	1	A	a	DT
cord-006229-7yoilsho	5052	2	similar	similar	JJ
cord-006229-7yoilsho	5052	3	increase	increase	NN
cord-006229-7yoilsho	5052	4	was	be	VBD
cord-006229-7yoilsho	5052	5	found	find	VBN
cord-006229-7yoilsho	5052	6	in	in	IN
cord-006229-7yoilsho	5052	7	B2	b2	NN
cord-006229-7yoilsho	5052	8	n	n	NN
cord-006229-7yoilsho	5052	9	(	(	-LRB-
cord-006229-7yoilsho	5052	10	4.45±0.25	4.45±0.25	CD
cord-006229-7yoilsho	5052	11	fold	fold	VB
cord-006229-7yoilsho	5052	12	,	,	,
cord-006229-7yoilsho	5052	13	n=7	n=7	JJ
cord-006229-7yoilsho	5052	14	,	,	,
cord-006229-7yoilsho	5052	15	P<0.0001	p<0.0001	JJ
cord-006229-7yoilsho	5052	16	vs.	vs.	IN
cord-006229-7yoilsho	5052	17	vehicle	vehicle	NN
cord-006229-7yoilsho	5052	18	)	)	-RRB-
cord-006229-7yoilsho	5052	19	,	,	,
cord-006229-7yoilsho	5052	20	while	while	IN
cord-006229-7yoilsho	5052	21	there	there	EX
cord-006229-7yoilsho	5052	22	was	be	VBD
cord-006229-7yoilsho	5052	23	a	a	DT
cord-006229-7yoilsho	5052	24	stronger	strong	JJR
cord-006229-7yoilsho	5052	25	response	response	NN
cord-006229-7yoilsho	5052	26	in	in	IN
cord-006229-7yoilsho	5052	27	B2	B2	NNP
cord-006229-7yoilsho	5052	28	tg	tg	NNP
cord-006229-7yoilsho	5052	29	(	(	-LRB-
cord-006229-7yoilsho	5052	30	5.50±0.16	5.50±0.16	RB
cord-006229-7yoilsho	5052	31	fold	fold	JJ
cord-006229-7yoilsho	5052	32	,	,	,
cord-006229-7yoilsho	5052	33	n=7	n=7	JJ
cord-006229-7yoilsho	5052	34	,	,	,
cord-006229-7yoilsho	5052	35	P<0.0001	p<0.0001	JJ
cord-006229-7yoilsho	5052	36	vs.	vs.	IN
cord-006229-7yoilsho	5052	37	vehicle	vehicle	NN
cord-006229-7yoilsho	5052	38	)	)	-RRB-
cord-006229-7yoilsho	5052	39	which	which	WDT
cord-006229-7yoilsho	5052	40	was	be	VBD
cord-006229-7yoilsho	5052	41	significantly	significantly	RB
cord-006229-7yoilsho	5052	42	different	different	JJ
cord-006229-7yoilsho	5052	43	to	to	IN
cord-006229-7yoilsho	5052	44	B2	b2	NN
cord-006229-7yoilsho	5052	45	n	n	NNP
cord-006229-7yoilsho	5052	46	(	(	-LRB-
cord-006229-7yoilsho	5052	47	P<0.01	P<0.01	NNP
cord-006229-7yoilsho	5052	48	)	)	-RRB-
cord-006229-7yoilsho	5052	49	and	and	CC
cord-006229-7yoilsho	5053	1	C57BL/6	C57BL/6	NNP
cord-006229-7yoilsho	5053	2	(	(	-LRB-
cord-006229-7yoilsho	5053	3	P<0.01	P<0.01	NNP
cord-006229-7yoilsho	5053	4	)	)	-RRB-
cord-006229-7yoilsho	5053	5	.	.	.
cord-006229-7yoilsho	5054	1	In	in	IN
cord-006229-7yoilsho	5054	2	another	another	DT
cord-006229-7yoilsho	5054	3	set	set	NN
cord-006229-7yoilsho	5054	4	of	of	IN
cord-006229-7yoilsho	5054	5	experiments	experiment	NNS
cord-006229-7yoilsho	5054	6	the	the	DT
cord-006229-7yoilsho	5054	7	specific	specific	JJ
cord-006229-7yoilsho	5054	8	and	and	CC
cord-006229-7yoilsho	5054	9	ACE	ace	NN
cord-006229-7yoilsho	5054	10	-	-	HYPH
cord-006229-7yoilsho	5054	11	resistant	resistant	JJ
cord-006229-7yoilsho	5054	12	B2	b2	NN
cord-006229-7yoilsho	5054	13	agonist	agonist	NN
cord-006229-7yoilsho	5054	14	labradimil	labradimil	NNP
cord-006229-7yoilsho	5054	15	(	(	-LRB-
cord-006229-7yoilsho	5054	16	1.89	1.89	CD
cord-006229-7yoilsho	5054	17	nmol	nmol	NN
cord-006229-7yoilsho	5054	18	)	)	-RRB-
cord-006229-7yoilsho	5054	19	was	be	VBD
cord-006229-7yoilsho	5054	20	used	use	VBN
cord-006229-7yoilsho	5054	21	instead	instead	RB
cord-006229-7yoilsho	5054	22	of	of	IN
cord-006229-7yoilsho	5054	23	bradykinin	bradykinin	NN
cord-006229-7yoilsho	5054	24	.	.	.
cord-006229-7yoilsho	5055	1	Labradimil	Labradimil	NNP
cord-006229-7yoilsho	5055	2	increased	increase	VBD
cord-006229-7yoilsho	5055	3	extravasation	extravasation	NN
cord-006229-7yoilsho	5055	4	by	by	IN
cord-006229-7yoilsho	5055	5	3.736±0.121	3.736±0.121	CD
cord-006229-7yoilsho	5055	6	fold	fold	VB
cord-006229-7yoilsho	5055	7	in	in	IN
cord-006229-7yoilsho	5055	8	C57BL/6	C57BL/6	NNP
cord-006229-7yoilsho	5056	1	(	(	-LRB-
cord-006229-7yoilsho	5056	2	n=6	n=6	UH
cord-006229-7yoilsho	5056	3	each	each	DT
cord-006229-7yoilsho	5056	4	,	,	,
cord-006229-7yoilsho	5056	5	P<0.0001	p<0.0001	JJ
cord-006229-7yoilsho	5056	6	vs.	vs.	IN
cord-006229-7yoilsho	5056	7	vehicle	vehicle	NN
cord-006229-7yoilsho	5056	8	)	)	-RRB-
cord-006229-7yoilsho	5056	9	,	,	,
cord-006229-7yoilsho	5056	10	by	by	IN
cord-006229-7yoilsho	5056	11	4.51±0.11	4.51±0.11	CD
cord-006229-7yoilsho	5056	12	fold	fold	NN
cord-006229-7yoilsho	5056	13	in	in	RB
cord-006229-7yoilsho	5057	1	BR2	BR2	NNP
cord-006229-7yoilsho	5057	2	n	n	NNP
cord-006229-7yoilsho	5057	3	(	(	-LRB-
cord-006229-7yoilsho	5057	4	n=7	n=7	PDT
cord-006229-7yoilsho	5057	5	each	each	DT
cord-006229-7yoilsho	5057	6	,	,	,
cord-006229-7yoilsho	5057	7	P<0.0001	p<0.0001	JJ
cord-006229-7yoilsho	5057	8	vs.	vs.	IN
cord-006229-7yoilsho	5057	9	vehicle	vehicle	NN
cord-006229-7yoilsho	5057	10	)	)	-RRB-
cord-006229-7yoilsho	5057	11	and	and	CC
cord-006229-7yoilsho	5057	12	4.88±0,21	4.88±0,21	LS
cord-006229-7yoilsho	5057	13	fold	fold	VB
cord-006229-7yoilsho	5057	14	in	in	RP
cord-006229-7yoilsho	5057	15	B2	B2	NNP
cord-006229-7yoilsho	5057	16	tg	tg	NNP
cord-006229-7yoilsho	5057	17	(	(	-LRB-
cord-006229-7yoilsho	5057	18	n=6	n=6	NNP
cord-006229-7yoilsho	5057	19	,	,	,
cord-006229-7yoilsho	5057	20	P<0.0001	p<0.0001	JJ
cord-006229-7yoilsho	5057	21	vs.	vs.	IN
cord-006229-7yoilsho	5057	22	vehicle	vehicle	NN
cord-006229-7yoilsho	5057	23	)	)	-RRB-
cord-006229-7yoilsho	5057	24	which	which	WDT
cord-006229-7yoilsho	5057	25	was	be	VBD
cord-006229-7yoilsho	5057	26	significantly	significantly	RB
cord-006229-7yoilsho	5057	27	different	different	JJ
cord-006229-7yoilsho	5057	28	to	to	IN
cord-006229-7yoilsho	5057	29	C57BL/6	c57bl/6	ADD
cord-006229-7yoilsho	5058	1	(	(	-LRB-
cord-006229-7yoilsho	5058	2	P<0.01	P<0.01	NNP
cord-006229-7yoilsho	5058	3	)	)	-RRB-
cord-006229-7yoilsho	5059	1	but	but	CC
cord-006229-7yoilsho	5059	2	not	not	RB
cord-006229-7yoilsho	5059	3	to	to	IN
cord-006229-7yoilsho	5059	4	B2	b2	NN
cord-006229-7yoilsho	5059	5	n	n	NNP
cord-006229-7yoilsho	5059	6	(	(	-LRB-
cord-006229-7yoilsho	5059	7	P>0.05	P>0.05	NNP
cord-006229-7yoilsho	5059	8	)	)	-RRB-
cord-006229-7yoilsho	5059	9	.	.	.
cord-006229-7yoilsho	5060	1	The	the	DT
cord-006229-7yoilsho	5060	2	effects	effect	NNS
cord-006229-7yoilsho	5060	3	of	of	IN
cord-006229-7yoilsho	5060	4	bradykinin	bradykinin	NN
cord-006229-7yoilsho	5060	5	and	and	CC
cord-006229-7yoilsho	5060	6	labradimil	labradimil	NNP
cord-006229-7yoilsho	5060	7	were	be	VBD
cord-006229-7yoilsho	5060	8	largely	largely	RB
cord-006229-7yoilsho	5060	9	blocked	block	VBN
cord-006229-7yoilsho	5060	10	by	by	IN
cord-006229-7yoilsho	5060	11	10	10	CD
cord-006229-7yoilsho	5060	12	nmol	nmol	JJ
cord-006229-7yoilsho	5060	13	icatibant	icatibant	NN
cord-006229-7yoilsho	5060	14	(	(	-LRB-
cord-006229-7yoilsho	5060	15	i.v	i.v	NNP
cord-006229-7yoilsho	5060	16	.	.	NNP
cord-006229-7yoilsho	5060	17	)	)	-RRB-
cord-006229-7yoilsho	5060	18	in	in	IN
cord-006229-7yoilsho	5060	19	C57Bl/6	C57Bl/6	NNP
cord-006229-7yoilsho	5060	20	,	,	,
cord-006229-7yoilsho	5060	21	B2	b2	NN
cord-006229-7yoilsho	5060	22	n	n	NNP
cord-006229-7yoilsho	5060	23	and	and	CC
cord-006229-7yoilsho	5060	24	B2	B2	NNP
cord-006229-7yoilsho	5060	25	tg	tg	NNP
cord-006229-7yoilsho	5060	26	mice	mice	NNP
cord-006229-7yoilsho	5060	27	(	(	-LRB-
cord-006229-7yoilsho	5060	28	P<0.0001	p<0.0001	JJ
cord-006229-7yoilsho	5060	29	)	)	-RRB-
cord-006229-7yoilsho	5060	30	and	and	CC
cord-006229-7yoilsho	5060	31	hence	hence	RB
cord-006229-7yoilsho	5060	32	mediated	mediate	VBN
cord-006229-7yoilsho	5060	33	by	by	IN
cord-006229-7yoilsho	5060	34	activation	activation	NN
cord-006229-7yoilsho	5060	35	of	of	IN
cord-006229-7yoilsho	5060	36	B2	b2	NN
cord-006229-7yoilsho	5060	37	.	.	.
cord-006229-7yoilsho	5061	1	These	these	DT
cord-006229-7yoilsho	5061	2	data	datum	NNS
cord-006229-7yoilsho	5061	3	suggest	suggest	VBP
cord-006229-7yoilsho	5061	4	that	that	IN
cord-006229-7yoilsho	5061	5	overexpression	overexpression	NN
cord-006229-7yoilsho	5061	6	of	of	IN
cord-006229-7yoilsho	5061	7	B2	b2	NN
cord-006229-7yoilsho	5061	8	in	in	IN
cord-006229-7yoilsho	5061	9	B2	B2	NNP
cord-006229-7yoilsho	5061	10	tg	tg	NNP
cord-006229-7yoilsho	5061	11	is	be	VBZ
cord-006229-7yoilsho	5061	12	functionally	functionally	RB
cord-006229-7yoilsho	5061	13	active	active	JJ
cord-006229-7yoilsho	5061	14	in	in	IN
cord-006229-7yoilsho	5061	15	endothelial	endothelial	JJ
cord-006229-7yoilsho	5061	16	cells	cell	NNS
cord-006229-7yoilsho	5061	17	of	of	IN
cord-006229-7yoilsho	5061	18	large	large	JJ
cord-006229-7yoilsho	5061	19	conductance	conductance	NN
cord-006229-7yoilsho	5061	20	and	and	CC
cord-006229-7yoilsho	5061	21	small	small	JJ
cord-006229-7yoilsho	5061	22	dermal	dermal	JJ
cord-006229-7yoilsho	5061	23	vessels	vessel	NNS
cord-006229-7yoilsho	5061	24	.	.	.
cord-006229-7yoilsho	5062	1	Therefore	therefore	RB
cord-006229-7yoilsho	5062	2	,	,	,
cord-006229-7yoilsho	5062	3	B2	B2	NNP
cord-006229-7yoilsho	5062	4	tg	tg	NNP
cord-006229-7yoilsho	5062	5	represents	represent	VBZ
cord-006229-7yoilsho	5062	6	a	a	DT
cord-006229-7yoilsho	5062	7	new	new	JJ
cord-006229-7yoilsho	5062	8	animal	animal	NN
cord-006229-7yoilsho	5062	9	model	model	NN
cord-006229-7yoilsho	5062	10	suitable	suitable	JJ
cord-006229-7yoilsho	5062	11	for	for	IN
cord-006229-7yoilsho	5062	12	cardiovascular	cardiovascular	JJ
cord-006229-7yoilsho	5062	13	and	and	CC
cord-006229-7yoilsho	5062	14	non	non	JJ
cord-006229-7yoilsho	5062	15	-	-	JJ
cord-006229-7yoilsho	5062	16	allergic	allergic	JJ
cord-006229-7yoilsho	5062	17	angioedema	angioedema	NN
cord-006229-7yoilsho	5062	18	research	research	NN
cord-006229-7yoilsho	5062	19	.	.	.
cord-006229-7yoilsho	5063	1	Pharmacokinetic	Pharmacokinetic	NNP
cord-006229-7yoilsho	5063	2	Pharmacodynamic	Pharmacodynamic	NNP
cord-006229-7yoilsho	5063	3	modeling	modeling	NN
cord-006229-7yoilsho	5063	4	of	of	IN
cord-006229-7yoilsho	5063	5	irreversible	irreversible	JJ
cord-006229-7yoilsho	5063	6	effects	effect	NNS
cord-006229-7yoilsho	5063	7	:	:	:
cord-006229-7yoilsho	5063	8	the	the	DT
cord-006229-7yoilsho	5063	9	Rituximab	Rituximab	NNP
cord-006229-7yoilsho	5063	10	example	example	NN
cord-006229-7yoilsho	5063	11	F.	F.	NNP
cord-006229-7yoilsho	5063	12	Keller	Keller	NNP
cord-006229-7yoilsho	5063	13	1	1	CD
cord-006229-7yoilsho	5063	14	1	1	CD
cord-006229-7yoilsho	5063	15	Universitätsklinikum	Universitätsklinikum	NNP
cord-006229-7yoilsho	5063	16	,	,	,
cord-006229-7yoilsho	5063	17	Innere	Innere	NNP
cord-006229-7yoilsho	5063	18	1	1	CD
cord-006229-7yoilsho	5063	19	,	,	,
cord-006229-7yoilsho	5063	20	Nephrologie	Nephrologie	NNP
cord-006229-7yoilsho	5063	21	,	,	,
cord-006229-7yoilsho	5063	22	Ulm	Ulm	NNP
cord-006229-7yoilsho	5063	23	,	,	,
cord-006229-7yoilsho	5064	1	Germany	Germany	NNP
cord-006229-7yoilsho	5064	2	Background	Background	NNP
cord-006229-7yoilsho	5064	3	:	:	:
cord-006229-7yoilsho	5065	1	For	for	IN
cord-006229-7yoilsho	5065	2	pharmacokinetic	pharmacokinetic	JJ
cord-006229-7yoilsho	5065	3	-	-	HYPH
cord-006229-7yoilsho	5065	4	pharmacodynamic	pharmacodynamic	JJ
cord-006229-7yoilsho	5065	5	modeling	modeling	NN
cord-006229-7yoilsho	5065	6	usually	usually	RB
cord-006229-7yoilsho	5065	7	the	the	DT
cord-006229-7yoilsho	5065	8	sigmoid	sigmoid	JJ
cord-006229-7yoilsho	5065	9	Emax	Emax	NNP
cord-006229-7yoilsho	5065	10	model	model	NN
cord-006229-7yoilsho	5065	11	is	be	VBZ
cord-006229-7yoilsho	5065	12	used	use	VBN
cord-006229-7yoilsho	5065	13	as	as	IN
cord-006229-7yoilsho	5065	14	described	describe	VBN
cord-006229-7yoilsho	5065	15	by	by	IN
cord-006229-7yoilsho	5065	16	the	the	DT
cord-006229-7yoilsho	5065	17	Hill	Hill	NNP
cord-006229-7yoilsho	5065	18	equation	equation	NN
cord-006229-7yoilsho	5065	19	.	.	.
cord-006229-7yoilsho	5066	1	However	however	RB
cord-006229-7yoilsho	5066	2	,	,	,
cord-006229-7yoilsho	5066	3	treatment	treatment	NN
cord-006229-7yoilsho	5066	4	regimens	regimen	NNS
cord-006229-7yoilsho	5066	5	exist	exist	VBP
cord-006229-7yoilsho	5066	6	where	where	WRB
cord-006229-7yoilsho	5066	7	the	the	DT
cord-006229-7yoilsho	5066	8	effect	effect	NN
cord-006229-7yoilsho	5066	9	is	be	VBZ
cord-006229-7yoilsho	5066	10	only	only	RB
cord-006229-7yoilsho	5066	11	exerted	exert	VBN
cord-006229-7yoilsho	5066	12	as	as	RB
cord-006229-7yoilsho	5066	13	long	long	RB
cord-006229-7yoilsho	5066	14	as	as	IN
cord-006229-7yoilsho	5066	15	the	the	DT
cord-006229-7yoilsho	5066	16	drug	drug	NN
cord-006229-7yoilsho	5066	17	concentration	concentration	NN
cord-006229-7yoilsho	5066	18	increases	increase	NNS
cord-006229-7yoilsho	5066	19	whereas	whereas	IN
cord-006229-7yoilsho	5066	20	decreasing	decrease	VBG
cord-006229-7yoilsho	5066	21	concentrations	concentration	NNS
cord-006229-7yoilsho	5066	22	produce	produce	VBP
cord-006229-7yoilsho	5066	23	no	no	RB
cord-006229-7yoilsho	5066	24	longer	long	RBR
cord-006229-7yoilsho	5066	25	an	an	DT
cord-006229-7yoilsho	5066	26	effect	effect	NN
cord-006229-7yoilsho	5066	27	.	.	.
cord-006229-7yoilsho	5067	1	Examples	example	NNS
cord-006229-7yoilsho	5067	2	are	be	VBP
cord-006229-7yoilsho	5067	3	the	the	DT
cord-006229-7yoilsho	5067	4	pulse	pulse	NN
cord-006229-7yoilsho	5067	5	anti	anti	JJ
cord-006229-7yoilsho	5067	6	-	-	JJ
cord-006229-7yoilsho	5067	7	cancer	cancer	JJ
cord-006229-7yoilsho	5067	8	therapy	therapy	NN
cord-006229-7yoilsho	5067	9	such	such	JJ
cord-006229-7yoilsho	5067	10	as	as	IN
cord-006229-7yoilsho	5067	11	originally	originally	RB
cord-006229-7yoilsho	5067	12	proposed	propose	VBN
cord-006229-7yoilsho	5067	13	by	by	IN
cord-006229-7yoilsho	5067	14	the	the	DT
cord-006229-7yoilsho	5067	15	DeVita	DeVita	NNP
cord-006229-7yoilsho	5067	16	protocols	protocol	NNS
cord-006229-7yoilsho	5067	17	.	.	.
cord-006229-7yoilsho	5068	1	Methods	method	NNS
cord-006229-7yoilsho	5068	2	:	:	:
cord-006229-7yoilsho	5068	3	Here	here	RB
cord-006229-7yoilsho	5068	4	,	,	,
cord-006229-7yoilsho	5068	5	the	the	DT
cord-006229-7yoilsho	5068	6	new	new	JJ
cord-006229-7yoilsho	5068	7	model	model	NN
cord-006229-7yoilsho	5068	8	for	for	IN
cord-006229-7yoilsho	5068	9	irreversible	irreversible	JJ
cord-006229-7yoilsho	5068	10	drug	drug	NN
cord-006229-7yoilsho	5068	11	action	action	NN
cord-006229-7yoilsho	5068	12	is	be	VBZ
cord-006229-7yoilsho	5068	13	derived	derive	VBN
cord-006229-7yoilsho	5068	14	from	from	IN
cord-006229-7yoilsho	5068	15	the	the	DT
cord-006229-7yoilsho	5068	16	time	time	NN
cord-006229-7yoilsho	5068	17	dependent	dependent	JJ
cord-006229-7yoilsho	5068	18	change	change	NN
cord-006229-7yoilsho	5068	19	of	of	IN
cord-006229-7yoilsho	5068	20	the	the	DT
cord-006229-7yoilsho	5068	21	concentration	concentration	NN
cord-006229-7yoilsho	5068	22	that	that	WDT
cord-006229-7yoilsho	5068	23	must	must	MD
cord-006229-7yoilsho	5068	24	be	be	VB
cord-006229-7yoilsho	5068	25	larger	large	JJR
cord-006229-7yoilsho	5068	26	than	than	IN
cord-006229-7yoilsho	5068	27	the	the	DT
cord-006229-7yoilsho	5068	28	time	time	NN
cord-006229-7yoilsho	5068	29	-	-	HYPH
cord-006229-7yoilsho	5068	30	dependent	dependent	JJ
cord-006229-7yoilsho	5068	31	growth	growth	NN
cord-006229-7yoilsho	5068	32	of	of	IN
cord-006229-7yoilsho	5068	33	the	the	DT
cord-006229-7yoilsho	5068	34	number	number	NN
cord-006229-7yoilsho	5068	35	of	of	IN
cord-006229-7yoilsho	5068	36	target	target	NN
cord-006229-7yoilsho	5068	37	cells	cell	NNS
cord-006229-7yoilsho	5068	38	(	(	-LRB-
cord-006229-7yoilsho	5068	39	tumor	tumor	NN
cord-006229-7yoilsho	5068	40	or	or	CC
cord-006229-7yoilsho	5068	41	bacteria	bacteria	NNS
cord-006229-7yoilsho	5068	42	)	)	-RRB-
cord-006229-7yoilsho	5068	43	.	.	.
cord-006229-7yoilsho	5069	1	The	the	DT
cord-006229-7yoilsho	5069	2	irreversible	irreversible	JJ
cord-006229-7yoilsho	5069	3	effect	effect	NN
cord-006229-7yoilsho	5069	4	can	can	MD
cord-006229-7yoilsho	5069	5	be	be	VB
cord-006229-7yoilsho	5069	6	assumed	assume	VBN
cord-006229-7yoilsho	5069	7	if	if	IN
cord-006229-7yoilsho	5069	8	the	the	DT
cord-006229-7yoilsho	5069	9	is	be	VBZ
cord-006229-7yoilsho	5069	10	no	no	DT
cord-006229-7yoilsho	5069	11	further	further	JJ
cord-006229-7yoilsho	5069	12	growth	growth	NN
cord-006229-7yoilsho	5069	13	of	of	IN
cord-006229-7yoilsho	5069	14	the	the	DT
cord-006229-7yoilsho	5069	15	target	target	NN
cord-006229-7yoilsho	5069	16	cells	cell	NNS
cord-006229-7yoilsho	5069	17	occurs	occur	VBZ
cord-006229-7yoilsho	5069	18	.	.	.
cord-006229-7yoilsho	5070	1	dE	dE	NNP
cord-006229-7yoilsho	5070	2	/	/	SYM
cord-006229-7yoilsho	5070	3	dt	dt	NN
cord-006229-7yoilsho	5071	1	=	=	NFP
cord-006229-7yoilsho	5071	2	+	+	CC
cord-006229-7yoilsho	5071	3	dC	dC	NNP
cord-006229-7yoilsho	5071	4	/	/	SYM
cord-006229-7yoilsho	5071	5	dt	dt	NN
cord-006229-7yoilsho	5071	6	-dN	-dN	NNP
cord-006229-7yoilsho	5072	1	/dt	/dt	.
cord-006229-7yoilsho	5072	2	dN	dN	NNP
cord-006229-7yoilsho	5072	3	/	/	SYM
cord-006229-7yoilsho	5072	4	dt	dt	NN
cord-006229-7yoilsho	5072	5	=	=	NN
cord-006229-7yoilsho	5072	6	0	0	NFP
cord-006229-7yoilsho	5073	1	A	a	DT
cord-006229-7yoilsho	5073	2	solution	solution	NN
cord-006229-7yoilsho	5073	3	for	for	IN
cord-006229-7yoilsho	5073	4	the	the	DT
cord-006229-7yoilsho	5073	5	above	above	JJ
cord-006229-7yoilsho	5073	6	differential	differential	JJ
cord-006229-7yoilsho	5073	7	equation	equation	NN
cord-006229-7yoilsho	5073	8	can	can	MD
cord-006229-7yoilsho	5073	9	be	be	VB
cord-006229-7yoilsho	5073	10	obtained	obtain	VBN
cord-006229-7yoilsho	5073	11	by	by	IN
cord-006229-7yoilsho	5073	12	use	use	NN
cord-006229-7yoilsho	5073	13	of	of	IN
cord-006229-7yoilsho	5073	14	the	the	DT
cord-006229-7yoilsho	5073	15	integral	integral	JJ
cord-006229-7yoilsho	5073	16	exponential	exponential	JJ
cord-006229-7yoilsho	5073	17	function	function	NN
cord-006229-7yoilsho	5073	18	IEC	IEC	NNP
cord-006229-7yoilsho	5073	19	based	base	VBN
cord-006229-7yoilsho	5073	20	on	on	IN
cord-006229-7yoilsho	5073	21	the	the	DT
cord-006229-7yoilsho	5073	22	Euler	Euler	NNP
cord-006229-7yoilsho	5073	23	-	-	HYPH
cord-006229-7yoilsho	5073	24	Mascheroni	Mascheroni	NNP
cord-006229-7yoilsho	5073	25	constant	constant	NN
cord-006229-7yoilsho	5073	26	(	(	-LRB-
cord-006229-7yoilsho	5073	27	gamma	gamma	NN
cord-006229-7yoilsho	5073	28	=	=	SYM
cord-006229-7yoilsho	5073	29	0.5772	0.5772	CD
cord-006229-7yoilsho	5073	30	…	…	NFP
cord-006229-7yoilsho	5073	31	)	)	-RRB-
cord-006229-7yoilsho	5073	32	.	.	.
cord-006229-7yoilsho	5074	1	This	this	DT
cord-006229-7yoilsho	5074	2	model	model	NN
cord-006229-7yoilsho	5074	3	of	of	IN
cord-006229-7yoilsho	5074	4	an	an	DT
cord-006229-7yoilsho	5074	5	irreversible	irreversible	JJ
cord-006229-7yoilsho	5074	6	effect	effect	NN
cord-006229-7yoilsho	5074	7	was	be	VBD
cord-006229-7yoilsho	5074	8	applied.to	applied.to	,
cord-006229-7yoilsho	5074	9	the	the	DT
cord-006229-7yoilsho	5074	10	example	example	NN
cord-006229-7yoilsho	5074	11	of	of	IN
cord-006229-7yoilsho	5074	12	rituximab	rituximab	NN
cord-006229-7yoilsho	5074	13	where	where	WRB
cord-006229-7yoilsho	5074	14	the	the	DT
cord-006229-7yoilsho	5074	15	initial	initial	JJ
cord-006229-7yoilsho	5074	16	effect	effect	NN
cord-006229-7yoilsho	5074	17	on	on	IN
cord-006229-7yoilsho	5074	18	CD19	CD19	NNP
cord-006229-7yoilsho	5074	19	+	+	CC
cord-006229-7yoilsho	5074	20	and	and	CC
cord-006229-7yoilsho	5074	21	CD20	cd20	NN
cord-006229-7yoilsho	5074	22	+	+	CC
cord-006229-7yoilsho	5074	23	B	b	NN
cord-006229-7yoilsho	5074	24	-	-	HYPH
cord-006229-7yoilsho	5074	25	cells	cell	NNS
cord-006229-7yoilsho	5074	26	completely	completely	RB
cord-006229-7yoilsho	5074	27	persists	persist	VBZ
cord-006229-7yoilsho	5074	28	for	for	IN
cord-006229-7yoilsho	5074	29	6	6	CD
cord-006229-7yoilsho	5074	30	month	month	NN
cord-006229-7yoilsho	5074	31	.	.	.
cord-006229-7yoilsho	5075	1	To	to	TO
cord-006229-7yoilsho	5075	2	obtain	obtain	VB
cord-006229-7yoilsho	5075	3	a	a	DT
cord-006229-7yoilsho	5075	4	numerical	numerical	JJ
cord-006229-7yoilsho	5075	5	solution	solution	NN
cord-006229-7yoilsho	5075	6	,	,	,
cord-006229-7yoilsho	5075	7	the	the	DT
cord-006229-7yoilsho	5075	8	following	follow	VBG
cord-006229-7yoilsho	5075	9	parameters	parameter	NNS
cord-006229-7yoilsho	5075	10	are	be	VBP
cord-006229-7yoilsho	5075	11	needed	need	VBN
cord-006229-7yoilsho	5075	12	to	to	TO
cord-006229-7yoilsho	5075	13	be	be	VB
cord-006229-7yoilsho	5075	14	determined	determine	VBN
cord-006229-7yoilsho	5075	15	:	:	:
cord-006229-7yoilsho	5075	16	the	the	DT
cord-006229-7yoilsho	5075	17	target	target	NN
cord-006229-7yoilsho	5075	18	concentration	concentration	NN
cord-006229-7yoilsho	5075	19	Ctarget	Ctarget	NNP
cord-006229-7yoilsho	5075	20	=	=	SYM
cord-006229-7yoilsho	5075	21	100	100	CD
cord-006229-7yoilsho	5075	22	mcg	mcg	NN
cord-006229-7yoilsho	5075	23	/	/	SYM
cord-006229-7yoilsho	5075	24	ml	ml	NN
cord-006229-7yoilsho	5075	25	and	and	CC
cord-006229-7yoilsho	5075	26	the	the	DT
cord-006229-7yoilsho	5075	27	infusion	infusion	NN
cord-006229-7yoilsho	5075	28	time	time	NN
cord-006229-7yoilsho	5075	29	T	t	NN
cord-006229-7yoilsho	5075	30	=	=	SYM
cord-006229-7yoilsho	5075	31	2	2	CD
cord-006229-7yoilsho	5075	32	hours	hour	NNS
cord-006229-7yoilsho	5075	33	.	.	.
cord-006229-7yoilsho	5076	1	Results	result	NNS
cord-006229-7yoilsho	5076	2	:	:	:
cord-006229-7yoilsho	5076	3	It	-PRON-	PRP
cord-006229-7yoilsho	5076	4	can	can	MD
cord-006229-7yoilsho	5076	5	be	be	VB
cord-006229-7yoilsho	5076	6	shown	show	VBN
cord-006229-7yoilsho	5076	7	that	that	IN
cord-006229-7yoilsho	5076	8	a	a	DT
cord-006229-7yoilsho	5076	9	plausible	plausible	JJ
cord-006229-7yoilsho	5076	10	result	result	NN
cord-006229-7yoilsho	5076	11	for	for	IN
cord-006229-7yoilsho	5076	12	rituximab	rituximab	NN
cord-006229-7yoilsho	5076	13	can	can	MD
cord-006229-7yoilsho	5076	14	be	be	VB
cord-006229-7yoilsho	5076	15	estimated	estimate	VBN
cord-006229-7yoilsho	5076	16	only	only	RB
cord-006229-7yoilsho	5076	17	under	under	IN
cord-006229-7yoilsho	5076	18	the	the	DT
cord-006229-7yoilsho	5076	19	condition	condition	NN
cord-006229-7yoilsho	5076	20	that	that	IN
cord-006229-7yoilsho	5076	21	a	a	DT
cord-006229-7yoilsho	5076	22	short	short	JJ
cord-006229-7yoilsho	5076	23	distribution	distribution	NN
cord-006229-7yoilsho	5076	24	half	half	JJ
cord-006229-7yoilsho	5076	25	-	-	HYPH
cord-006229-7yoilsho	5076	26	life	life	NN
cord-006229-7yoilsho	5076	27	is	be	VBZ
cord-006229-7yoilsho	5076	28	assumed	assume	VBN
cord-006229-7yoilsho	5076	29	of	of	IN
cord-006229-7yoilsho	5076	30	T1/2	T1/2	NNP
cord-006229-7yoilsho	5076	31	=	=	SYM
cord-006229-7yoilsho	5076	32	2	2	CD
cord-006229-7yoilsho	5076	33	hours	hour	NNS
cord-006229-7yoilsho	5076	34	(	(	-LRB-
cord-006229-7yoilsho	5076	35	not	not	RB
cord-006229-7yoilsho	5076	36	shorter	short	JJR
cord-006229-7yoilsho	5076	37	than	than	IN
cord-006229-7yoilsho	5076	38	the	the	DT
cord-006229-7yoilsho	5076	39	time	time	NN
cord-006229-7yoilsho	5076	40	T	t	NN
cord-006229-7yoilsho	5076	41	of	of	IN
cord-006229-7yoilsho	5076	42	infusion	infusion	NN
cord-006229-7yoilsho	5076	43	)	)	-RRB-
cord-006229-7yoilsho	5076	44	.	.	.
cord-006229-7yoilsho	5077	1	With	with	IN
cord-006229-7yoilsho	5077	2	the	the	DT
cord-006229-7yoilsho	5077	3	terminal	terminal	JJ
cord-006229-7yoilsho	5077	4	half	half	JJ
cord-006229-7yoilsho	5077	5	-	-	HYPH
cord-006229-7yoilsho	5077	6	life	life	NN
cord-006229-7yoilsho	5077	7	of	of	IN
cord-006229-7yoilsho	5077	8	460	460	CD
cord-006229-7yoilsho	5077	9	hours	hour	NNS
cord-006229-7yoilsho	5077	10	no	no	DT
cord-006229-7yoilsho	5077	11	plausible	plausible	JJ
cord-006229-7yoilsho	5077	12	solution	solution	NN
cord-006229-7yoilsho	5077	13	is	be	VBZ
cord-006229-7yoilsho	5077	14	obtained	obtain	VBN
cord-006229-7yoilsho	5077	15	.	.	.
cord-006229-7yoilsho	5078	1	Under	under	IN
cord-006229-7yoilsho	5078	2	these	these	DT
cord-006229-7yoilsho	5078	3	conditions	condition	NNS
cord-006229-7yoilsho	5078	4	two	two	CD
cord-006229-7yoilsho	5078	5	observations	observation	NNS
cord-006229-7yoilsho	5078	6	are	be	VBP
cord-006229-7yoilsho	5078	7	made	make	VBN
cord-006229-7yoilsho	5079	1	:	:	:
cord-006229-7yoilsho	5079	2	There	there	EX
cord-006229-7yoilsho	5079	3	is	be	VBZ
cord-006229-7yoilsho	5079	4	a	a	DT
cord-006229-7yoilsho	5079	5	negative	negative	JJ
cord-006229-7yoilsho	5079	6	effect	effect	NN
cord-006229-7yoilsho	5079	7	both	both	DT
cord-006229-7yoilsho	5079	8	,	,	,
cord-006229-7yoilsho	5079	9	initially	initially	RB
cord-006229-7yoilsho	5079	10	for	for	IN
cord-006229-7yoilsho	5079	11	low	low	JJ
cord-006229-7yoilsho	5079	12	concentrations	concentration	NNS
cord-006229-7yoilsho	5079	13	and	and	CC
cord-006229-7yoilsho	5079	14	after	after	IN
cord-006229-7yoilsho	5079	15	cessation	cessation	NN
cord-006229-7yoilsho	5079	16	of	of	IN
cord-006229-7yoilsho	5079	17	the	the	DT
cord-006229-7yoilsho	5079	18	infusion	infusion	NN
cord-006229-7yoilsho	5079	19	when	when	WRB
cord-006229-7yoilsho	5079	20	concentrations	concentration	NNS
cord-006229-7yoilsho	5079	21	decrease	decrease	VBP
cord-006229-7yoilsho	5079	22	(	(	-LRB-
cord-006229-7yoilsho	5079	23	in	in	IN
cord-006229-7yoilsho	5079	24	reality	reality	NN
cord-006229-7yoilsho	5079	25	this	this	DT
cord-006229-7yoilsho	5079	26	means	mean	VBZ
cord-006229-7yoilsho	5079	27	no	no	DT
cord-006229-7yoilsho	5079	28	effect	effect	NN
cord-006229-7yoilsho	5079	29	in	in	IN
cord-006229-7yoilsho	5079	30	both	both	DT
cord-006229-7yoilsho	5079	31	cases	case	NNS
cord-006229-7yoilsho	5079	32	)	)	-RRB-
cord-006229-7yoilsho	5079	33	.	.	.
cord-006229-7yoilsho	5080	1	The	the	DT
cord-006229-7yoilsho	5080	2	irreversible	irreversible	JJ
cord-006229-7yoilsho	5080	3	effect	effect	NN
cord-006229-7yoilsho	5080	4	is	be	VBZ
cord-006229-7yoilsho	5080	5	proportional	proportional	JJ
cord-006229-7yoilsho	5080	6	to	to	IN
cord-006229-7yoilsho	5080	7	the	the	DT
cord-006229-7yoilsho	5080	8	target	target	NN
cord-006229-7yoilsho	5080	9	concentration	concentration	NN
cord-006229-7yoilsho	5080	10	.	.	.
cord-006229-7yoilsho	5081	1	The	the	DT
cord-006229-7yoilsho	5081	2	shorter	short	JJR
cord-006229-7yoilsho	5081	3	the	the	DT
cord-006229-7yoilsho	5081	4	half	half	JJ
cord-006229-7yoilsho	5081	5	-	-	HYPH
cord-006229-7yoilsho	5081	6	life	life	NN
cord-006229-7yoilsho	5081	7	comes	come	VBZ
cord-006229-7yoilsho	5081	8	out	out	RP
cord-006229-7yoilsho	5081	9	relative	relative	JJ
cord-006229-7yoilsho	5081	10	to	to	IN
cord-006229-7yoilsho	5081	11	the	the	DT
cord-006229-7yoilsho	5081	12	infusion	infusion	NN
cord-006229-7yoilsho	5081	13	time	time	NN
cord-006229-7yoilsho	5082	1	(	(	-LRB-
cord-006229-7yoilsho	5082	2	T1/2	T1/2	NNP
cord-006229-7yoilsho	5082	3	<	<	XX
cord-006229-7yoilsho	5082	4	T	T	NNP
cord-006229-7yoilsho	5082	5	)	)	-RRB-
cord-006229-7yoilsho	5082	6	the	the	DT
cord-006229-7yoilsho	5082	7	stronger	strong	JJR
cord-006229-7yoilsho	5082	8	is	be	VBZ
cord-006229-7yoilsho	5082	9	the	the	DT
cord-006229-7yoilsho	5082	10	effect	effect	NN
cord-006229-7yoilsho	5082	11	(	(	-LRB-
cord-006229-7yoilsho	5082	12	Figure	figure	NN
cord-006229-7yoilsho	5082	13	)	)	-RRB-
cord-006229-7yoilsho	5082	14	.	.	.
cord-006229-7yoilsho	5083	1	Occasionally	occasionally	RB
cord-006229-7yoilsho	5083	2	there	there	EX
cord-006229-7yoilsho	5083	3	are	be	VBP
cord-006229-7yoilsho	5083	4	specific	specific	JJ
cord-006229-7yoilsho	5083	5	questions	question	NNS
cord-006229-7yoilsho	5083	6	occurring	occur	VBG
cord-006229-7yoilsho	5083	7	on	on	IN
cord-006229-7yoilsho	5083	8	the	the	DT
cord-006229-7yoilsho	5083	9	ruminant	ruminant	NN
cord-006229-7yoilsho	5083	10	xenobiotic	xenobiotic	JJ
cord-006229-7yoilsho	5083	11	metabolism	metabolism	NN
cord-006229-7yoilsho	5083	12	:	:	:
cord-006229-7yoilsho	5083	13	1	1	LS
cord-006229-7yoilsho	5083	14	)	)	-RRB-
cord-006229-7yoilsho	5083	15	are	be	VBP
cord-006229-7yoilsho	5083	16	the	the	DT
cord-006229-7yoilsho	5083	17	observed	observed	JJ
cord-006229-7yoilsho	5083	18	metabolites	metabolite	NNS
cord-006229-7yoilsho	5083	19	ruminant	ruminant	NN
cord-006229-7yoilsho	5083	20	specific	specific	JJ
cord-006229-7yoilsho	5083	21	and	and	CC
cord-006229-7yoilsho	5083	22	formed	form	VBN
cord-006229-7yoilsho	5083	23	directly	directly	RB
cord-006229-7yoilsho	5083	24	in	in	IN
cord-006229-7yoilsho	5083	25	the	the	DT
cord-006229-7yoilsho	5083	26	rumen	rumen	NN
cord-006229-7yoilsho	5083	27	?	?	.
cord-006229-7yoilsho	5083	28	2	2	LS
cord-006229-7yoilsho	5083	29	)	)	-RRB-
cord-006229-7yoilsho	5083	30	are	be	VBP
cord-006229-7yoilsho	5083	31	ruminants	ruminant	NNS
cord-006229-7yoilsho	5083	32	able	able	JJ
cord-006229-7yoilsho	5083	33	to	to	TO
cord-006229-7yoilsho	5083	34	cleave	cleave	VB
cord-006229-7yoilsho	5083	35	plant	plant	NN
cord-006229-7yoilsho	5083	36	specific	specific	JJ
cord-006229-7yoilsho	5083	37	metabolites	metabolite	NNS
cord-006229-7yoilsho	5083	38	like	like	IN
cord-006229-7yoilsho	5083	39	glycosides	glycoside	NNS
cord-006229-7yoilsho	5083	40	to	to	IN
cord-006229-7yoilsho	5083	41	the	the	DT
cord-006229-7yoilsho	5083	42	respective	respective	JJ
cord-006229-7yoilsho	5083	43	aglycon	aglycon	NN
cord-006229-7yoilsho	5083	44	?	?	.
cord-006229-7yoilsho	5084	1	In	in	IN
cord-006229-7yoilsho	5084	2	the	the	DT
cord-006229-7yoilsho	5084	3	past	past	JJ
cord-006229-7yoilsho	5084	4	new	new	JJ
cord-006229-7yoilsho	5084	5	additional	additional	JJ
cord-006229-7yoilsho	5084	6	in	in	IN
cord-006229-7yoilsho	5084	7	vivo	vivo	NNP
cord-006229-7yoilsho	5084	8	goat	goat	NN
cord-006229-7yoilsho	5084	9	metabolism	metabolism	NN
cord-006229-7yoilsho	5084	10	studies	study	NNS
cord-006229-7yoilsho	5084	11	with	with	IN
cord-006229-7yoilsho	5084	12	at	at	RB
cord-006229-7yoilsho	5084	13	least	least	RBS
cord-006229-7yoilsho	5084	14	one	one	CD
cord-006229-7yoilsho	5084	15	animal	animal	NN
cord-006229-7yoilsho	5084	16	were	be	VBD
cord-006229-7yoilsho	5084	17	performed	perform	VBN
cord-006229-7yoilsho	5084	18	.	.	.
cord-006229-7yoilsho	5085	1	The	the	DT
cord-006229-7yoilsho	5085	2	aim	aim	NN
cord-006229-7yoilsho	5085	3	of	of	IN
cord-006229-7yoilsho	5085	4	the	the	DT
cord-006229-7yoilsho	5085	5	project	project	NN
cord-006229-7yoilsho	5085	6	was	be	VBD
cord-006229-7yoilsho	5085	7	to	to	TO
cord-006229-7yoilsho	5085	8	elucidate	elucidate	VB
cord-006229-7yoilsho	5085	9	an	an	DT
cord-006229-7yoilsho	5085	10	alternative	alternative	NN
cord-006229-7yoilsho	5085	11	in	in	IN
cord-006229-7yoilsho	5085	12	-	-	HYPH
cord-006229-7yoilsho	5085	13	vitro	vitro	FW
cord-006229-7yoilsho	5085	14	method	method	NN
cord-006229-7yoilsho	5085	15	to	to	TO
cord-006229-7yoilsho	5085	16	replace	replace	VB
cord-006229-7yoilsho	5085	17	the	the	DT
cord-006229-7yoilsho	5085	18	existing	exist	VBG
cord-006229-7yoilsho	5085	19	in	in	IN
cord-006229-7yoilsho	5085	20	vivo	vivo	NN
cord-006229-7yoilsho	5085	21	method	method	NN
cord-006229-7yoilsho	5085	22	in	in	IN
cord-006229-7yoilsho	5085	23	order	order	NN
cord-006229-7yoilsho	5085	24	to	to	TO
cord-006229-7yoilsho	5085	25	address	address	VB
cord-006229-7yoilsho	5085	26	robustly	robustly	RB
cord-006229-7yoilsho	5085	27	specific	specific	JJ
cord-006229-7yoilsho	5085	28	questions	question	NNS
cord-006229-7yoilsho	5085	29	on	on	IN
cord-006229-7yoilsho	5085	30	xenobiotic	xenobiotic	JJ
cord-006229-7yoilsho	5085	31	metabolism	metabolism	NN
cord-006229-7yoilsho	5085	32	in	in	IN
cord-006229-7yoilsho	5085	33	ruminants	ruminant	NNS
cord-006229-7yoilsho	5085	34	for	for	IN
cord-006229-7yoilsho	5085	35	registration	registration	NN
cord-006229-7yoilsho	5085	36	of	of	IN
cord-006229-7yoilsho	5085	37	PPP	PPP	NNP
cord-006229-7yoilsho	5085	38	.	.	.
cord-006229-7yoilsho	5086	1	Fresh	fresh	JJ
cord-006229-7yoilsho	5086	2	sheep	sheep	NN
cord-006229-7yoilsho	5086	3	rumen	rumen	NN
cord-006229-7yoilsho	5086	4	fluid	fluid	NN
cord-006229-7yoilsho	5086	5	was	be	VBD
cord-006229-7yoilsho	5086	6	incubated	incubate	VBN
cord-006229-7yoilsho	5086	7	in	in	IN
cord-006229-7yoilsho	5086	8	-	-	HYPH
cord-006229-7yoilsho	5086	9	vitro	vitro	FW
cord-006229-7yoilsho	5086	10	>	>	XX
cord-006229-7yoilsho	5086	11	7	7	CD
cord-006229-7yoilsho	5086	12	days	day	NNS
cord-006229-7yoilsho	5086	13	by	by	IN
cord-006229-7yoilsho	5086	14	using	use	VBG
cord-006229-7yoilsho	5086	15	rumen	rumen	NN
cord-006229-7yoilsho	5086	16	simulation	simulation	NN
cord-006229-7yoilsho	5086	17	technology	technology	NN
cord-006229-7yoilsho	5086	18	(	(	-LRB-
cord-006229-7yoilsho	5086	19	RUSITEC	RUSITEC	NNP
cord-006229-7yoilsho	5086	20	)	)	-RRB-
cord-006229-7yoilsho	5086	21	.	.	.
cord-006229-7yoilsho	5087	1	The	the	DT
cord-006229-7yoilsho	5087	2	conservation	conservation	NN
cord-006229-7yoilsho	5087	3	of	of	IN
cord-006229-7yoilsho	5087	4	the	the	DT
cord-006229-7yoilsho	5087	5	physiological	physiological	JJ
cord-006229-7yoilsho	5087	6	conditions	condition	NNS
cord-006229-7yoilsho	5087	7	were	be	VBD
cord-006229-7yoilsho	5087	8	proven	prove	VBN
cord-006229-7yoilsho	5087	9	by	by	IN
cord-006229-7yoilsho	5087	10	measurement	measurement	NN
cord-006229-7yoilsho	5087	11	of	of	IN
cord-006229-7yoilsho	5087	12	pH	pH	NNP
cord-006229-7yoilsho	5088	1	(	(	-LRB-
cord-006229-7yoilsho	5088	2	~pH	~pH	VBZ
cord-006229-7yoilsho	5088	3	6.6	6.6	CD
cord-006229-7yoilsho	5088	4	)	)	-RRB-
cord-006229-7yoilsho	5088	5	and	and	CC
cord-006229-7yoilsho	5088	6	Redox	Redox	NNP
cord-006229-7yoilsho	5088	7	potential	potential	NN
cord-006229-7yoilsho	5088	8	(	(	-LRB-
cord-006229-7yoilsho	5088	9	~-300	~-300	NNP
cord-006229-7yoilsho	5088	10	mV	mV	NNP
cord-006229-7yoilsho	5088	11	)	)	-RRB-
cord-006229-7yoilsho	5088	12	.	.	.
cord-006229-7yoilsho	5089	1	The	the	DT
cord-006229-7yoilsho	5089	2	microflora	microflora	NN
cord-006229-7yoilsho	5089	3	composition	composition	NN
cord-006229-7yoilsho	5089	4	and	and	CC
cord-006229-7yoilsho	5089	5	their	-PRON-	PRP$
cord-006229-7yoilsho	5089	6	viability	viability	NN
cord-006229-7yoilsho	5089	7	(	(	-LRB-
cord-006229-7yoilsho	5089	8	bacteria	bacteria	NNS
cord-006229-7yoilsho	5089	9	,	,	,
cord-006229-7yoilsho	5089	10	protozoa	protozoan	NNS
cord-006229-7yoilsho	5089	11	and	and	CC
cord-006229-7yoilsho	5089	12	fungi	fungus	NNS
cord-006229-7yoilsho	5089	13	)	)	-RRB-
cord-006229-7yoilsho	5089	14	of	of	IN
cord-006229-7yoilsho	5089	15	the	the	DT
cord-006229-7yoilsho	5089	16	rumen	rumen	NN
cord-006229-7yoilsho	5089	17	were	be	VBD
cord-006229-7yoilsho	5089	18	monitored	monitor	VBN
cord-006229-7yoilsho	5089	19	by	by	IN
cord-006229-7yoilsho	5089	20	microscopy	microscopy	NNS
cord-006229-7yoilsho	5089	21	,	,	,
cord-006229-7yoilsho	5089	22	incubation	incubation	NN
cord-006229-7yoilsho	5089	23	on	on	IN
cord-006229-7yoilsho	5089	24	agar	agar	NN
cord-006229-7yoilsho	5089	25	plates	plate	NNS
cord-006229-7yoilsho	5089	26	and	and	CC
cord-006229-7yoilsho	5089	27	performing	perform	VBG
cord-006229-7yoilsho	5089	28	several	several	JJ
cord-006229-7yoilsho	5089	29	viability	viability	NN
cord-006229-7yoilsho	5089	30	tests	test	NNS
cord-006229-7yoilsho	5089	31	(	(	-LRB-
cord-006229-7yoilsho	5089	32	e.g.	e.g.	IN
cord-006229-7yoilsho	5089	33	Glycosidase	Glycosidase	NNP
cord-006229-7yoilsho	5089	34	-	-	HYPH
cord-006229-7yoilsho	5089	35	Test	Test	NNP
cord-006229-7yoilsho	5089	36	,	,	,
cord-006229-7yoilsho	5089	37	NH3	NH3	NNP
cord-006229-7yoilsho	5089	38	and	and	CC
cord-006229-7yoilsho	5089	39	Short	short	JJ
cord-006229-7yoilsho	5089	40	fatty	fatty	JJ
cord-006229-7yoilsho	5089	41	acids	acid	NNS
cord-006229-7yoilsho	5089	42	)	)	-RRB-
cord-006229-7yoilsho	5089	43	.	.	.
cord-006229-7yoilsho	5090	1	All	all	PDT
cord-006229-7yoilsho	5090	2	the	the	DT
cord-006229-7yoilsho	5090	3	tests	test	NNS
cord-006229-7yoilsho	5090	4	showed	show	VBD
cord-006229-7yoilsho	5090	5	that	that	IN
cord-006229-7yoilsho	5090	6	the	the	DT
cord-006229-7yoilsho	5090	7	RUSITEC	RUSITEC	NNP
cord-006229-7yoilsho	5090	8	is	be	VBZ
cord-006229-7yoilsho	5090	9	a	a	DT
cord-006229-7yoilsho	5090	10	successful	successful	JJ
cord-006229-7yoilsho	5090	11	tool	tool	NN
cord-006229-7yoilsho	5090	12	to	to	TO
cord-006229-7yoilsho	5090	13	maintain	maintain	VB
cord-006229-7yoilsho	5090	14	sheep	sheep	NN
cord-006229-7yoilsho	5090	15	rumen	rumen	NN
cord-006229-7yoilsho	5090	16	fluid	fluid	NN
cord-006229-7yoilsho	5090	17	for	for	IN
cord-006229-7yoilsho	5090	18	at	at	RB
cord-006229-7yoilsho	5090	19	least	least	JJS
cord-006229-7yoilsho	5090	20	7	7	CD
cord-006229-7yoilsho	5090	21	days	day	NNS
cord-006229-7yoilsho	5090	22	in	in	IN
cord-006229-7yoilsho	5090	23	-vitro	-vitro	NN
cord-006229-7yoilsho	5090	24	.	.	.
cord-006229-7yoilsho	5091	1	The	the	DT
cord-006229-7yoilsho	5091	2	metabolic	metabolic	JJ
cord-006229-7yoilsho	5091	3	behavior	behavior	NN
cord-006229-7yoilsho	5091	4	and	and	CC
cord-006229-7yoilsho	5091	5	performance	performance	NN
cord-006229-7yoilsho	5091	6	of	of	IN
cord-006229-7yoilsho	5091	7	the	the	DT
cord-006229-7yoilsho	5091	8	rumen	rumen	NN
cord-006229-7yoilsho	5091	9	fluid	fluid	NN
cord-006229-7yoilsho	5091	10	was	be	VBD
cord-006229-7yoilsho	5091	11	tested	test	VBN
cord-006229-7yoilsho	5091	12	by	by	IN
cord-006229-7yoilsho	5091	13	e.g.	e.g.	RB
cord-006229-7yoilsho	5091	14	incubating	incubate	VBG
cord-006229-7yoilsho	5091	15	14C	14c	JJ
cord-006229-7yoilsho	5091	16	-	-	HYPH
cord-006229-7yoilsho	5091	17	triazol	triazol	JJ
cord-006229-7yoilsho	5091	18	derivative	derivative	JJ
cord-006229-7yoilsho	5091	19	metabolites	metabolite	NNS
cord-006229-7yoilsho	5091	20	(	(	-LRB-
cord-006229-7yoilsho	5091	21	TDM	TDM	NNP
cord-006229-7yoilsho	5091	22	)	)	-RRB-
cord-006229-7yoilsho	5091	23	like	like	IN
cord-006229-7yoilsho	5091	24	Triazol	Triazol	NNP
cord-006229-7yoilsho	5091	25	-	-	HYPH
cord-006229-7yoilsho	5091	26	Alanin	Alanin	NNP
cord-006229-7yoilsho	5091	27	(	(	-LRB-
cord-006229-7yoilsho	5091	28	TA	TA	NNP
cord-006229-7yoilsho	5091	29	)	)	-RRB-
cord-006229-7yoilsho	5091	30	;	;	:
cord-006229-7yoilsho	5091	31	Triazol	Triazol	NNP
cord-006229-7yoilsho	5091	32	-	-	HYPH
cord-006229-7yoilsho	5091	33	Acetic	acetic	NN
cord-006229-7yoilsho	5091	34	-	-	HYPH
cord-006229-7yoilsho	5091	35	acid	acid	NN
cord-006229-7yoilsho	5091	36	(	(	-LRB-
cord-006229-7yoilsho	5091	37	TAA	TAA	NNP
cord-006229-7yoilsho	5091	38	)	)	-RRB-
cord-006229-7yoilsho	5091	39	and	and	CC
cord-006229-7yoilsho	5091	40	Triazol	Triazol	NNP
cord-006229-7yoilsho	5091	41	-	-	HYPH
cord-006229-7yoilsho	5091	42	Lactic	lactic	NN
cord-006229-7yoilsho	5091	43	-	-	HYPH
cord-006229-7yoilsho	5091	44	acid	acid	NN
cord-006229-7yoilsho	5091	45	(	(	-LRB-
cord-006229-7yoilsho	5091	46	TLA	TLA	NNP
cord-006229-7yoilsho	5091	47	)	)	-RRB-
cord-006229-7yoilsho	5091	48	,	,	,
cord-006229-7yoilsho	5091	49	which	which	WDT
cord-006229-7yoilsho	5091	50	are	be	VBP
cord-006229-7yoilsho	5091	51	usually	usually	RB
cord-006229-7yoilsho	5091	52	formed	form	VBN
cord-006229-7yoilsho	5091	53	in	in	IN
cord-006229-7yoilsho	5091	54	plants	plant	NNS
cord-006229-7yoilsho	5091	55	after	after	IN
cord-006229-7yoilsho	5091	56	application	application	NN
cord-006229-7yoilsho	5091	57	of	of	IN
cord-006229-7yoilsho	5091	58	triazol	triazol	NNP
cord-006229-7yoilsho	5091	59	-	-	HYPH
cord-006229-7yoilsho	5091	60	containing	contain	VBG
cord-006229-7yoilsho	5091	61	fungicides	fungicide	NNS
cord-006229-7yoilsho	5091	62	.	.	.
cord-006229-7yoilsho	5092	1	It	-PRON-	PRP
cord-006229-7yoilsho	5092	2	was	be	VBD
cord-006229-7yoilsho	5092	3	shown	show	VBN
cord-006229-7yoilsho	5092	4	that	that	IN
cord-006229-7yoilsho	5092	5	TA	TA	NNP
cord-006229-7yoilsho	5092	6	was	be	VBD
cord-006229-7yoilsho	5092	7	cleaved	cleave	VBN
cord-006229-7yoilsho	5092	8	within	within	IN
cord-006229-7yoilsho	5092	9	72	72	CD
cord-006229-7yoilsho	5092	10	h	h	NN
cord-006229-7yoilsho	5092	11	to	to	IN
cord-006229-7yoilsho	5092	12	1.2.4.-Triazol	1.2.4.-triazol	CD
cord-006229-7yoilsho	5092	13	,	,	,
cord-006229-7yoilsho	5092	14	while	while	IN
cord-006229-7yoilsho	5092	15	TAA	TAA	NNP
cord-006229-7yoilsho	5092	16	and	and	CC
cord-006229-7yoilsho	5092	17	TLA	TLA	NNP
cord-006229-7yoilsho	5092	18	were	be	VBD
cord-006229-7yoilsho	5092	19	stable	stable	JJ
cord-006229-7yoilsho	5092	20	under	under	IN
cord-006229-7yoilsho	5092	21	these	these	DT
cord-006229-7yoilsho	5092	22	conditions	condition	NNS
cord-006229-7yoilsho	5092	23	.	.	.
cord-006229-7yoilsho	5093	1	These	these	DT
cord-006229-7yoilsho	5093	2	data	datum	NNS
cord-006229-7yoilsho	5093	3	are	be	VBP
cord-006229-7yoilsho	5093	4	in	in	IN
cord-006229-7yoilsho	5093	5	a	a	DT
cord-006229-7yoilsho	5093	6	good	good	JJ
cord-006229-7yoilsho	5093	7	accordance	accordance	NN
cord-006229-7yoilsho	5093	8	with	with	IN
cord-006229-7yoilsho	5093	9	available	available	JJ
cord-006229-7yoilsho	5093	10	in	in	IN
cord-006229-7yoilsho	5093	11	vivo	vivo	NN
cord-006229-7yoilsho	5093	12	data	datum	NNS
cord-006229-7yoilsho	5093	13	in	in	IN
cord-006229-7yoilsho	5093	14	cows	cow	NNS
cord-006229-7yoilsho	5093	15	.	.	.
cord-006229-7yoilsho	5094	1	Moreover	moreover	RB
cord-006229-7yoilsho	5094	2	glycosides	glycoside	NNS
cord-006229-7yoilsho	5094	3	(	(	-LRB-
cord-006229-7yoilsho	5094	4	12C	12C	NNP
cord-006229-7yoilsho	5094	5	-	-	HYPH
cord-006229-7yoilsho	5094	6	Polydatin	Polydatin	NNP
cord-006229-7yoilsho	5094	7	,	,	,
cord-006229-7yoilsho	5094	8	Octyl-14C	octyl-14c	NN
cord-006229-7yoilsho	5094	9	-	-	HYPH
cord-006229-7yoilsho	5094	10	β	β	NN
cord-006229-7yoilsho	5094	11	-	-	HYPH
cord-006229-7yoilsho	5094	12	D	D	NNP
cord-006229-7yoilsho	5094	13	-	-	HYPH
cord-006229-7yoilsho	5094	14	glucopyranosid	glucopyranosid	NNP
cord-006229-7yoilsho	5094	15	)	)	-RRB-
cord-006229-7yoilsho	5094	16	were	be	VBD
cord-006229-7yoilsho	5094	17	cleaved	cleave	VBN
cord-006229-7yoilsho	5094	18	within	within	IN
cord-006229-7yoilsho	5094	19	1	1	CD
cord-006229-7yoilsho	5094	20	hour	hour	NN
cord-006229-7yoilsho	5094	21	completely	completely	RB
cord-006229-7yoilsho	5094	22	.	.	.
cord-006229-7yoilsho	5095	1	All	all	PDT
cord-006229-7yoilsho	5095	2	these	these	DT
cord-006229-7yoilsho	5095	3	data	datum	NNS
cord-006229-7yoilsho	5095	4	show	show	VBP
cord-006229-7yoilsho	5095	5	,	,	,
cord-006229-7yoilsho	5095	6	that	that	IN
cord-006229-7yoilsho	5095	7	the	the	DT
cord-006229-7yoilsho	5095	8	rumen	rumen	NN
cord-006229-7yoilsho	5095	9	fluid	fluid	NN
cord-006229-7yoilsho	5095	10	maintained	maintain	VBD
cord-006229-7yoilsho	5095	11	its	-PRON-	PRP$
cord-006229-7yoilsho	5095	12	metabolic	metabolic	JJ
cord-006229-7yoilsho	5095	13	performance	performance	NN
cord-006229-7yoilsho	5095	14	by	by	IN
cord-006229-7yoilsho	5095	15	using	use	VBG
cord-006229-7yoilsho	5095	16	RUSITEC	RUSITEC	NNP
cord-006229-7yoilsho	5095	17	.	.	.
cord-006229-7yoilsho	5096	1	BASF	BASF	NNP
cord-006229-7yoilsho	5096	2	identified	identify	VBD
cord-006229-7yoilsho	5096	3	the	the	DT
cord-006229-7yoilsho	5096	4	RUSITEC	rusitec	JJ
cord-006229-7yoilsho	5096	5	method	method	NN
cord-006229-7yoilsho	5096	6	,	,	,
cord-006229-7yoilsho	5096	7	which	which	WDT
cord-006229-7yoilsho	5096	8	is	be	VBZ
cord-006229-7yoilsho	5096	9	usually	usually	RB
cord-006229-7yoilsho	5096	10	used	use	VBN
cord-006229-7yoilsho	5096	11	in	in	IN
cord-006229-7yoilsho	5096	12	different	different	JJ
cord-006229-7yoilsho	5096	13	areas	area	NNS
cord-006229-7yoilsho	5096	14	(	(	-LRB-
cord-006229-7yoilsho	5097	1	e.g.	e.g.	IN
cord-006229-7yoilsho	5097	2	investigation	investigation	NN
cord-006229-7yoilsho	5097	3	of	of	IN
cord-006229-7yoilsho	5097	4	methane	methane	NN
cord-006229-7yoilsho	5097	5	production	production	NN
cord-006229-7yoilsho	5097	6	in	in	IN
cord-006229-7yoilsho	5097	7	-	-	HYPH
cord-006229-7yoilsho	5097	8	vitro	vitro	FW
cord-006229-7yoilsho	5097	9	)	)	-RRB-
cord-006229-7yoilsho	5097	10	as	as	IN
cord-006229-7yoilsho	5097	11	suitable	suitable	JJ
cord-006229-7yoilsho	5097	12	and	and	CC
cord-006229-7yoilsho	5097	13	adapted	adapt	VBD
cord-006229-7yoilsho	5097	14	this	this	DT
cord-006229-7yoilsho	5097	15	method	method	NN
cord-006229-7yoilsho	5097	16	for	for	IN
cord-006229-7yoilsho	5097	17	the	the	DT
cord-006229-7yoilsho	5097	18	purpose	purpose	NN
cord-006229-7yoilsho	5097	19	of	of	IN
cord-006229-7yoilsho	5097	20	investigation	investigation	NN
cord-006229-7yoilsho	5097	21	of	of	IN
cord-006229-7yoilsho	5097	22	ruminant	ruminant	NN
cord-006229-7yoilsho	5097	23	xenobiotic	xenobiotic	JJ
cord-006229-7yoilsho	5097	24	metabolism	metabolism	NN
cord-006229-7yoilsho	5097	25	.	.	.
cord-006229-7yoilsho	5098	1	It	-PRON-	PRP
cord-006229-7yoilsho	5098	2	was	be	VBD
cord-006229-7yoilsho	5098	3	shown	show	VBN
cord-006229-7yoilsho	5098	4	that	that	IN
cord-006229-7yoilsho	5098	5	RUSITEC	RUSITEC	NNP
cord-006229-7yoilsho	5098	6	is	be	VBZ
cord-006229-7yoilsho	5098	7	a	a	DT
cord-006229-7yoilsho	5098	8	robust	robust	JJ
cord-006229-7yoilsho	5098	9	method	method	NN
cord-006229-7yoilsho	5098	10	to	to	TO
cord-006229-7yoilsho	5098	11	analyze	analyze	VB
cord-006229-7yoilsho	5098	12	rumen	rumen	NN
cord-006229-7yoilsho	5098	13	xenobiotic	xenobiotic	JJ
cord-006229-7yoilsho	5098	14	metabolism	metabolism	NN
cord-006229-7yoilsho	5098	15	and	and	CC
cord-006229-7yoilsho	5098	16	therefore	therefore	RB
cord-006229-7yoilsho	5098	17	can	can	MD
cord-006229-7yoilsho	5098	18	clearly	clearly	RB
cord-006229-7yoilsho	5098	19	substitute	substitute	VB
cord-006229-7yoilsho	5098	20	in	in	IN
cord-006229-7yoilsho	5098	21	vivo	vivo	NNP
cord-006229-7yoilsho	5098	22	animal	animal	NN
cord-006229-7yoilsho	5098	23	studies	study	NNS
cord-006229-7yoilsho	5098	24	on	on	IN
cord-006229-7yoilsho	5098	25	ruminant	ruminant	NN
cord-006229-7yoilsho	5098	26	metabolism	metabolism	NN
cord-006229-7yoilsho	5098	27	studies	study	NNS
cord-006229-7yoilsho	5098	28	beyond	beyond	IN
cord-006229-7yoilsho	5098	29	OECD503	OECD503	NNP
cord-006229-7yoilsho	5098	30	and	and	CC
cord-006229-7yoilsho	5098	31	contribute	contribute	VB
cord-006229-7yoilsho	5098	32	significantly	significantly	RB
cord-006229-7yoilsho	5098	33	to	to	IN
cord-006229-7yoilsho	5098	34	animal	animal	NN
cord-006229-7yoilsho	5098	35	welfare	welfare	NN
cord-006229-7yoilsho	5098	36	(	(	-LRB-
cord-006229-7yoilsho	5098	37	3R	3R	NNP
cord-006229-7yoilsho	5098	38	:	:	:
cord-006229-7yoilsho	5098	39	replacement	replacement	NN
cord-006229-7yoilsho	5098	40	)	)	-RRB-
cord-006229-7yoilsho	5098	41	.	.	.
cord-006229-7yoilsho	5099	1	Results	result	NNS
cord-006229-7yoilsho	5099	2	:	:	:
cord-006229-7yoilsho	5100	1	By	by	IN
cord-006229-7yoilsho	5100	2	using	use	VBG
cord-006229-7yoilsho	5100	3	the	the	DT
cord-006229-7yoilsho	5100	4	training	training	NN
cord-006229-7yoilsho	5100	5	set	set	NN
cord-006229-7yoilsho	5100	6	,	,	,
cord-006229-7yoilsho	5100	7	physicochemical	physicochemical	JJ
cord-006229-7yoilsho	5100	8	(	(	-LRB-
cord-006229-7yoilsho	5100	9	e.g.	e.g.	IN
cord-006229-7yoilsho	5100	10	lipophilicity	lipophilicity	NN
cord-006229-7yoilsho	5100	11	)	)	-RRB-
cord-006229-7yoilsho	5100	12	and	and	CC
cord-006229-7yoilsho	5100	13	pharmacokinetic	pharmacokinetic	JJ
cord-006229-7yoilsho	5100	14	characteristics	characteristic	NNS
cord-006229-7yoilsho	5100	15	of	of	IN
cord-006229-7yoilsho	5100	16	MTX	MTX	NNP
cord-006229-7yoilsho	5100	17	(	(	-LRB-
cord-006229-7yoilsho	5100	18	e.g.	e.g.	RB
cord-006229-7yoilsho	5100	19	V	v	NN
cord-006229-7yoilsho	5100	20	max	max	NN
cord-006229-7yoilsho	5100	21	for	for	IN
cord-006229-7yoilsho	5100	22	active	active	JJ
cord-006229-7yoilsho	5100	23	tubular	tubular	JJ
cord-006229-7yoilsho	5100	24	secretion	secretion	NN
cord-006229-7yoilsho	5100	25	)	)	-RRB-
cord-006229-7yoilsho	5100	26	were	be	VBD
cord-006229-7yoilsho	5100	27	slightly	slightly	RB
cord-006229-7yoilsho	5100	28	adjusted	adjust	VBN
cord-006229-7yoilsho	5100	29	.	.	.
cord-006229-7yoilsho	5101	1	Using	use	VBG
cord-006229-7yoilsho	5101	2	the	the	DT
cord-006229-7yoilsho	5101	3	GFR	GFR	NNP
cord-006229-7yoilsho	5101	4	formula	formula	NN
cord-006229-7yoilsho	5101	5	of	of	IN
cord-006229-7yoilsho	5101	6	Morris	Morris	NNP
cord-006229-7yoilsho	5101	7	et	et	NNP
cord-006229-7yoilsho	5101	8	al	al	NNP
cord-006229-7yoilsho	5101	9	.	.	.
cord-006229-7yoilsho	5102	1	(	(	-LRB-
cord-006229-7yoilsho	5102	2	1982	1982	CD
cord-006229-7yoilsho	5102	3	)	)	-RRB-
cord-006229-7yoilsho	5103	1	and	and	CC
cord-006229-7yoilsho	5103	2	including	include	VBG
cord-006229-7yoilsho	5103	3	an	an	DT
cord-006229-7yoilsho	5103	4	empiric	empiric	JJ
cord-006229-7yoilsho	5103	5	correction	correction	NN
cord-006229-7yoilsho	5103	6	factor	factor	NN
cord-006229-7yoilsho	5103	7	,	,	,
cord-006229-7yoilsho	5103	8	MRD	MRD	NNP
cord-006229-7yoilsho	5103	9	for	for	IN
cord-006229-7yoilsho	5103	10	the	the	DT
cord-006229-7yoilsho	5103	11	training	training	NN
cord-006229-7yoilsho	5103	12	set	set	NN
cord-006229-7yoilsho	5103	13	was	be	VBD
cord-006229-7yoilsho	5103	14	2.49	2.49	CD
cord-006229-7yoilsho	5103	15	whereas	whereas	IN
cord-006229-7yoilsho	5103	16	bias	bias	NN
cord-006229-7yoilsho	5103	17	was	be	VBD
cord-006229-7yoilsho	5103	18	2.80	2.80	CD
cord-006229-7yoilsho	5103	19	µmol	µmol	NNP
cord-006229-7yoilsho	5103	20	/	/	SYM
cord-006229-7yoilsho	5103	21	l	l	NN
cord-006229-7yoilsho	5103	22	.	.	.
cord-006229-7yoilsho	5104	1	By	by	IN
cord-006229-7yoilsho	5104	2	applying	apply	VBG
cord-006229-7yoilsho	5104	3	the	the	DT
cord-006229-7yoilsho	5104	4	developed	develop	VBN
cord-006229-7yoilsho	5104	5	PBPK	PBPK	NNP
cord-006229-7yoilsho	5104	6	model	model	NN
cord-006229-7yoilsho	5104	7	to	to	IN
cord-006229-7yoilsho	5104	8	the	the	DT
cord-006229-7yoilsho	5104	9	test	test	NN
cord-006229-7yoilsho	5104	10	set	set	VBD
cord-006229-7yoilsho	5104	11	the	the	DT
cord-006229-7yoilsho	5104	12	respective	respective	JJ
cord-006229-7yoilsho	5104	13	values	value	NNS
cord-006229-7yoilsho	5104	14	were	be	VBD
cord-006229-7yoilsho	5105	1	MRD=3.92	MRD=3.92	NNP
cord-006229-7yoilsho	5105	2	and	and	CC
cord-006229-7yoilsho	5105	3	Bias=1.43	Bias=1.43	NNP
cord-006229-7yoilsho	5105	4	µmol	µmol	NNP
cord-006229-7yoilsho	5105	5	/	/	SYM
cord-006229-7yoilsho	5105	6	l	l	NN
cord-006229-7yoilsho	5105	7	.	.	.
cord-006229-7yoilsho	5106	1	For	for	IN
cord-006229-7yoilsho	5106	2	the	the	DT
cord-006229-7yoilsho	5106	3	covariates	covariate	NNS
cord-006229-7yoilsho	5106	4	"	"	``
cord-006229-7yoilsho	5106	5	at	at	IN
cord-006229-7yoilsho	5106	6	least	least	JJS
cord-006229-7yoilsho	5106	7	one	one	CD
cord-006229-7yoilsho	5106	8	potentially	potentially	RB
cord-006229-7yoilsho	5106	9	interacting	interact	VBG
cord-006229-7yoilsho	5106	10	co	co	JJ
cord-006229-7yoilsho	5106	11	-	-	JJ
cord-006229-7yoilsho	5106	12	medication	medication	NN
cord-006229-7yoilsho	5106	13	"	"	''
cord-006229-7yoilsho	5106	14	and	and	CC
cord-006229-7yoilsho	5106	15	"	"	``
cord-006229-7yoilsho	5106	16	trimethoprime	trimethoprime	NNP
cord-006229-7yoilsho	5106	17	/	/	SYM
cord-006229-7yoilsho	5106	18	sulfamethoxazole	sulfamethoxazole	NN
cord-006229-7yoilsho	5106	19	"	"	``
cord-006229-7yoilsho	5106	20	a	a	DT
cord-006229-7yoilsho	5106	21	significant	significant	JJ
cord-006229-7yoilsho	5106	22	impact	impact	NN
cord-006229-7yoilsho	5106	23	on	on	IN
cord-006229-7yoilsho	5106	24	the	the	DT
cord-006229-7yoilsho	5106	25	prediction	prediction	NN
cord-006229-7yoilsho	5106	26	quality	quality	NN
cord-006229-7yoilsho	5106	27	was	be	VBD
cord-006229-7yoilsho	5106	28	found	find	VBN
cord-006229-7yoilsho	5106	29	.	.	.
cord-006229-7yoilsho	5107	1	Conclusions	conclusion	NNS
cord-006229-7yoilsho	5107	2	:	:	:
cord-006229-7yoilsho	5108	1	Using	use	VBG
cord-006229-7yoilsho	5108	2	the	the	DT
cord-006229-7yoilsho	5108	3	developed	develop	VBN
cord-006229-7yoilsho	5108	4	PBPK	PBPK	NNP
cord-006229-7yoilsho	5108	5	-	-	HYPH
cord-006229-7yoilsho	5108	6	Model	Model	NNP
cord-006229-7yoilsho	5108	7	,	,	,
cord-006229-7yoilsho	5108	8	a	a	DT
cord-006229-7yoilsho	5108	9	good	good	JJ
cord-006229-7yoilsho	5108	10	prediction	prediction	NN
cord-006229-7yoilsho	5108	11	of	of	IN
cord-006229-7yoilsho	5108	12	the	the	DT
cord-006229-7yoilsho	5108	13	pharmacokinetics	pharmacokinetic	NNS
cord-006229-7yoilsho	5108	14	of	of	IN
cord-006229-7yoilsho	5108	15	HD	HD	NNP
cord-006229-7yoilsho	5108	16	MTX	MTX	NNP
cord-006229-7yoilsho	5108	17	in	in	IN
cord-006229-7yoilsho	5108	18	severely	severely	RB
cord-006229-7yoilsho	5108	19	ill	ill	JJ
cord-006229-7yoilsho	5108	20	children	child	NNS
cord-006229-7yoilsho	5108	21	was	be	VBD
cord-006229-7yoilsho	5108	22	found	find	VBN
cord-006229-7yoilsho	5108	23	.	.	.
cord-006229-7yoilsho	5109	1	By	by	IN
cord-006229-7yoilsho	5109	2	including	include	VBG
cord-006229-7yoilsho	5109	3	additional	additional	JJ
cord-006229-7yoilsho	5109	4	factors	factor	NNS
cord-006229-7yoilsho	5109	5	influencing	influence	VBG
cord-006229-7yoilsho	5109	6	the	the	DT
cord-006229-7yoilsho	5109	7	prediction	prediction	NN
cord-006229-7yoilsho	5109	8	of	of	IN
cord-006229-7yoilsho	5109	9	MTX	MTX	NNP
cord-006229-7yoilsho	5109	10	characteristics	characteristic	NNS
cord-006229-7yoilsho	5109	11	(	(	-LRB-
cord-006229-7yoilsho	5109	12	e.g.	e.g.	IN
cord-006229-7yoilsho	5109	13	co	co	NN
cord-006229-7yoilsho	5109	14	-	-	NNS
cord-006229-7yoilsho	5109	15	medications	medication	NNS
cord-006229-7yoilsho	5109	16	)	)	-RRB-
cord-006229-7yoilsho	5109	17	an	an	DT
cord-006229-7yoilsho	5109	18	improved	improved	JJ
cord-006229-7yoilsho	5109	19	prediction	prediction	NN
cord-006229-7yoilsho	5109	20	of	of	IN
cord-006229-7yoilsho	5109	21	MTX	MTX	NNP
cord-006229-7yoilsho	5109	22	-	-	HYPH
cord-006229-7yoilsho	5109	23	SL	SL	NNP
cord-006229-7yoilsho	5109	24	might	may	MD
cord-006229-7yoilsho	5109	25	be	be	VB
cord-006229-7yoilsho	5109	26	reached	reach	VBN
cord-006229-7yoilsho	5109	27	.	.	.
cord-006229-7yoilsho	5110	1	In	in	IN
cord-006229-7yoilsho	5110	2	prospective	prospective	JJ
cord-006229-7yoilsho	5110	3	clinical	clinical	JJ
cord-006229-7yoilsho	5110	4	trials	trial	NNS
cord-006229-7yoilsho	5110	5	,	,	,
cord-006229-7yoilsho	5110	6	those	those	DT
cord-006229-7yoilsho	5110	7	more	more	RBR
cord-006229-7yoilsho	5110	8	complex	complex	JJ
cord-006229-7yoilsho	5110	9	models	model	NNS
cord-006229-7yoilsho	5110	10	should	should	MD
cord-006229-7yoilsho	5110	11	be	be	VB
cord-006229-7yoilsho	5110	12	evaluated	evaluate	VBN
cord-006229-7yoilsho	5110	13	and	and	CC
cord-006229-7yoilsho	5110	14	might	may	MD
cord-006229-7yoilsho	5110	15	be	be	VB
cord-006229-7yoilsho	5110	16	helpful	helpful	JJ
cord-006229-7yoilsho	5110	17	to	to	TO
cord-006229-7yoilsho	5110	18	predict	predict	VB
cord-006229-7yoilsho	5110	19	HD	HD	NNP
cord-006229-7yoilsho	5110	20	MTX	MTX	NNP
cord-006229-7yoilsho	5110	21	pharmacokinetics	pharmacokinetic	NNS
cord-006229-7yoilsho	5110	22	and	and	CC
cord-006229-7yoilsho	5110	23	reduce	reduce	VB
cord-006229-7yoilsho	5110	24	unwanted	unwanted	JJ
cord-006229-7yoilsho	5110	25	side	side	NN
cord-006229-7yoilsho	5110	26	effects	effect	NNS
cord-006229-7yoilsho	5110	27	.	.	.
cord-006229-7yoilsho	5111	1	Hypericin	Hypericin	NNP
cord-006229-7yoilsho	5111	2	is	be	VBZ
cord-006229-7yoilsho	5111	3	a	a	DT
cord-006229-7yoilsho	5111	4	natural	natural	JJ
cord-006229-7yoilsho	5111	5	polycyclic	polycyclic	NN
cord-006229-7yoilsho	5111	6	quinone	quinone	NN
cord-006229-7yoilsho	5111	7	found	find	VBN
cord-006229-7yoilsho	5111	8	in	in	IN
cord-006229-7yoilsho	5111	9	Hypericum	Hypericum	NNP
cord-006229-7yoilsho	5111	10	perforatum	perforatum	NN
cord-006229-7yoilsho	5111	11	.	.	.
cord-006229-7yoilsho	5112	1	Although	although	IN
cord-006229-7yoilsho	5112	2	hypericin	hypericin	NNS
cord-006229-7yoilsho	5112	3	reportedly	reportedly	RB
cord-006229-7yoilsho	5112	4	has	have	VBZ
cord-006229-7yoilsho	5112	5	numerous	numerous	JJ
cord-006229-7yoilsho	5112	6	pharmacological	pharmacological	JJ
cord-006229-7yoilsho	5112	7	activities	activity	NNS
cord-006229-7yoilsho	5112	8	,	,	,
cord-006229-7yoilsho	5112	9	only	only	RB
cord-006229-7yoilsho	5112	10	a	a	DT
cord-006229-7yoilsho	5112	11	limited	limited	JJ
cord-006229-7yoilsho	5112	12	number	number	NN
cord-006229-7yoilsho	5112	13	of	of	IN
cord-006229-7yoilsho	5112	14	studies	study	NNS
cord-006229-7yoilsho	5112	15	have	have	VBP
cord-006229-7yoilsho	5112	16	been	be	VBN
cord-006229-7yoilsho	5112	17	performed	perform	VBN
cord-006229-7yoilsho	5112	18	on	on	IN
cord-006229-7yoilsho	5112	19	the	the	DT
cord-006229-7yoilsho	5112	20	absorption	absorption	NN
cord-006229-7yoilsho	5112	21	and	and	CC
cord-006229-7yoilsho	5112	22	transport	transport	NN
cord-006229-7yoilsho	5112	23	characteristics	characteristic	NNS
cord-006229-7yoilsho	5112	24	of	of	IN
cord-006229-7yoilsho	5112	25	this	this	DT
cord-006229-7yoilsho	5112	26	compound	compound	NN
cord-006229-7yoilsho	5112	27	,	,	,
cord-006229-7yoilsho	5112	28	presumably	presumably	RB
cord-006229-7yoilsho	5112	29	,	,	,
cord-006229-7yoilsho	5112	30	because	because	IN
cord-006229-7yoilsho	5112	31	hypericin	hypericin	NN
cord-006229-7yoilsho	5112	32	is	be	VBZ
cord-006229-7yoilsho	5112	33	a	a	DT
cord-006229-7yoilsho	5112	34	highly	highly	RB
cord-006229-7yoilsho	5112	35	lipophilic	lipophilic	JJ
cord-006229-7yoilsho	5112	36	compound	compound	NN
cord-006229-7yoilsho	5112	37	which	which	WDT
cord-006229-7yoilsho	5112	38	is	be	VBZ
cord-006229-7yoilsho	5112	39	poorly	poorly	RB
cord-006229-7yoilsho	5112	40	soluble	soluble	JJ
cord-006229-7yoilsho	5112	41	in	in	IN
cord-006229-7yoilsho	5112	42	physiological	physiological	JJ
cord-006229-7yoilsho	5112	43	medium	medium	NN
cord-006229-7yoilsho	5112	44	.	.	.
cord-006229-7yoilsho	5113	1	Recently	recently	RB
cord-006229-7yoilsho	5113	2	we	-PRON-	PRP
cord-006229-7yoilsho	5113	3	have	have	VBP
cord-006229-7yoilsho	5113	4	shown	show	VBN
cord-006229-7yoilsho	5113	5	that	that	IN
cord-006229-7yoilsho	5113	6	quercitrin	quercitrin	NNP
cord-006229-7yoilsho	5113	7	and	and	CC
cord-006229-7yoilsho	5113	8	isoquercitrin	isoquercitrin	NNP
cord-006229-7yoilsho	5113	9	,	,	,
cord-006229-7yoilsho	5113	10	but	but	CC
cord-006229-7yoilsho	5113	11	not	not	RB
cord-006229-7yoilsho	5113	12	hyerosid	hyerosid	NN
cord-006229-7yoilsho	5113	13	,	,	,
cord-006229-7yoilsho	5113	14	quercetin	quercetin	NN
cord-006229-7yoilsho	5113	15	or	or	CC
cord-006229-7yoilsho	5113	16	rutin	rutin	NN
cord-006229-7yoilsho	5113	17	increased	increase	VBD
cord-006229-7yoilsho	5113	18	the	the	DT
cord-006229-7yoilsho	5113	19	uptake	uptake	NN
cord-006229-7yoilsho	5113	20	of	of	IN
cord-006229-7yoilsho	5113	21	hypericin	hypericin	NNS
cord-006229-7yoilsho	5113	22	in	in	IN
cord-006229-7yoilsho	5113	23	Caco-2	Caco-2	NNP
cord-006229-7yoilsho	5113	24	cells	cell	NNS
cord-006229-7yoilsho	5113	25	.	.	.
cord-006229-7yoilsho	5114	1	The	the	DT
cord-006229-7yoilsho	5114	2	major	major	JJ
cord-006229-7yoilsho	5114	3	aim	aim	NN
cord-006229-7yoilsho	5114	4	of	of	IN
cord-006229-7yoilsho	5114	5	this	this	DT
cord-006229-7yoilsho	5114	6	study	study	NN
cord-006229-7yoilsho	5114	7	was	be	VBD
cord-006229-7yoilsho	5114	8	to	to	TO
cord-006229-7yoilsho	5114	9	get	get	VB
cord-006229-7yoilsho	5114	10	a	a	DT
cord-006229-7yoilsho	5114	11	detailed	detailed	JJ
cord-006229-7yoilsho	5114	12	understanding	understanding	NN
cord-006229-7yoilsho	5114	13	of	of	IN
cord-006229-7yoilsho	5114	14	the	the	DT
cord-006229-7yoilsho	5114	15	exposure	exposure	NN
cord-006229-7yoilsho	5114	16	and	and	CC
cord-006229-7yoilsho	5114	17	fate	fate	NN
cord-006229-7yoilsho	5114	18	of	of	IN
cord-006229-7yoilsho	5114	19	hypericin	hypericin	NNS
cord-006229-7yoilsho	5114	20	in	in	IN
cord-006229-7yoilsho	5114	21	the	the	DT
cord-006229-7yoilsho	5114	22	Caco-2	Caco-2	NNP
cord-006229-7yoilsho	5114	23	cell	cell	NN
cord-006229-7yoilsho	5114	24	system	system	NN
cord-006229-7yoilsho	5114	25	under	under	IN
cord-006229-7yoilsho	5114	26	different	different	JJ
cord-006229-7yoilsho	5114	27	experimental	experimental	JJ
cord-006229-7yoilsho	5114	28	conditions	condition	NNS
cord-006229-7yoilsho	5114	29	.	.	.
cord-006229-7yoilsho	5115	1	The	the	DT
cord-006229-7yoilsho	5115	2	permeation	permeation	NN
cord-006229-7yoilsho	5115	3	characteristics	characteristic	NNS
cord-006229-7yoilsho	5115	4	of	of	IN
cord-006229-7yoilsho	5115	5	hypericin	hypericin	NNS
cord-006229-7yoilsho	5115	6	(	(	-LRB-
cord-006229-7yoilsho	5115	7	5	5	CD
cord-006229-7yoilsho	5115	8	µM	µm	CD
cord-006229-7yoilsho	5115	9	)	)	-RRB-
cord-006229-7yoilsho	5115	10	in	in	IN
cord-006229-7yoilsho	5115	11	absence	absence	NN
cord-006229-7yoilsho	5115	12	or	or	CC
cord-006229-7yoilsho	5115	13	presence	presence	NN
cord-006229-7yoilsho	5115	14	of	of	IN
cord-006229-7yoilsho	5115	15	hypericum	hypericum	NNP
cord-006229-7yoilsho	5115	16	extract	extract	NNP
cord-006229-7yoilsho	5115	17	145	145	CD
cord-006229-7yoilsho	5115	18	,	,	,
cord-006229-7yoilsho	5115	19	62.5	62.5	CD
cord-006229-7yoilsho	5115	20	µg	µg	NN
cord-006229-7yoilsho	5115	21	/	/	SYM
cord-006229-7yoilsho	5115	22	ml	ml	NN
cord-006229-7yoilsho	5115	23	)	)	-RRB-
cord-006229-7yoilsho	5115	24	were	be	VBD
cord-006229-7yoilsho	5115	25	studied	study	VBN
cord-006229-7yoilsho	5115	26	in	in	IN
cord-006229-7yoilsho	5115	27	the	the	DT
cord-006229-7yoilsho	5115	28	absorptive	absorptive	JJ
cord-006229-7yoilsho	5115	29	direction	direction	NN
cord-006229-7yoilsho	5115	30	.	.	.
cord-006229-7yoilsho	5116	1	Following	follow	VBG
cord-006229-7yoilsho	5116	2	application	application	NN
cord-006229-7yoilsho	5116	3	of	of	IN
cord-006229-7yoilsho	5116	4	hypericin	hypericin	NNS
cord-006229-7yoilsho	5116	5	to	to	IN
cord-006229-7yoilsho	5116	6	the	the	DT
cord-006229-7yoilsho	5116	7	apical	apical	JJ
cord-006229-7yoilsho	5116	8	side	side	NN
cord-006229-7yoilsho	5116	9	of	of	IN
cord-006229-7yoilsho	5116	10	the	the	DT
cord-006229-7yoilsho	5116	11	monolayer	monolayer	NN
cord-006229-7yoilsho	5116	12	only	only	RB
cord-006229-7yoilsho	5116	13	negligible	negligible	JJ
cord-006229-7yoilsho	5116	14	amounts	amount	NNS
cord-006229-7yoilsho	5116	15	of	of	IN
cord-006229-7yoilsho	5116	16	the	the	DT
cord-006229-7yoilsho	5116	17	compound	compound	NN
cord-006229-7yoilsho	5116	18	were	be	VBD
cord-006229-7yoilsho	5116	19	found	find	VBN
cord-006229-7yoilsho	5116	20	in	in	IN
cord-006229-7yoilsho	5116	21	the	the	DT
cord-006229-7yoilsho	5116	22	basolateral	basolateral	JJ
cord-006229-7yoilsho	5116	23	compartment	compartment	NN
cord-006229-7yoilsho	5116	24	.	.	.
cord-006229-7yoilsho	5117	1	The	the	DT
cord-006229-7yoilsho	5117	2	amount	amount	NN
cord-006229-7yoilsho	5117	3	of	of	IN
cord-006229-7yoilsho	5117	4	hypericin	hypericin	NNS
cord-006229-7yoilsho	5117	5	in	in	IN
cord-006229-7yoilsho	5117	6	the	the	DT
cord-006229-7yoilsho	5117	7	basolateral	basolateral	JJ
cord-006229-7yoilsho	5117	8	compartment	compartment	NN
cord-006229-7yoilsho	5117	9	increased	increase	VBD
cord-006229-7yoilsho	5117	10	concentration	concentration	NN
cord-006229-7yoilsho	5117	11	-	-	:
cord-006229-7yoilsho	5117	12	dependently	dependently	RB
cord-006229-7yoilsho	5117	13	in	in	IN
cord-006229-7yoilsho	5117	14	the	the	DT
cord-006229-7yoilsho	5117	15	presence	presence	NN
cord-006229-7yoilsho	5117	16	of	of	IN
cord-006229-7yoilsho	5117	17	the	the	DT
cord-006229-7yoilsho	5117	18	extract	extract	NN
cord-006229-7yoilsho	5117	19	(	(	-LRB-
cord-006229-7yoilsho	5117	20	from	from	IN
cord-006229-7yoilsho	5117	21	0	0	CD
cord-006229-7yoilsho	5117	22	to	to	IN
cord-006229-7yoilsho	5117	23	7.5	7.5	CD
cord-006229-7yoilsho	5117	24	%	%	NN
cord-006229-7yoilsho	5117	25	)	)	-RRB-
cord-006229-7yoilsho	5117	26	.	.	.
cord-006229-7yoilsho	5118	1	The	the	DT
cord-006229-7yoilsho	5118	2	majority	majority	NN
cord-006229-7yoilsho	5118	3	of	of	IN
cord-006229-7yoilsho	5118	4	hypericin	hypericin	NNS
cord-006229-7yoilsho	5118	5	was	be	VBD
cord-006229-7yoilsho	5118	6	found	find	VBN
cord-006229-7yoilsho	5118	7	after	after	IN
cord-006229-7yoilsho	5118	8	cell	cell	NN
cord-006229-7yoilsho	5118	9	extraction	extraction	NN
cord-006229-7yoilsho	5118	10	(	(	-LRB-
cord-006229-7yoilsho	5118	11	44	44	CD
cord-006229-7yoilsho	5118	12	%	%	NN
cord-006229-7yoilsho	5118	13	in	in	IN
cord-006229-7yoilsho	5118	14	absence	absence	NN
cord-006229-7yoilsho	5118	15	and	and	CC
cord-006229-7yoilsho	5118	16	76	76	CD
cord-006229-7yoilsho	5118	17	%	%	NN
cord-006229-7yoilsho	5118	18	in	in	IN
cord-006229-7yoilsho	5118	19	presence	presence	NN
cord-006229-7yoilsho	5118	20	of	of	IN
cord-006229-7yoilsho	5118	21	the	the	DT
cord-006229-7yoilsho	5118	22	extract	extract	NN
cord-006229-7yoilsho	5118	23	)	)	-RRB-
cord-006229-7yoilsho	5118	24	.	.	.
cord-006229-7yoilsho	5119	1	The	the	DT
cord-006229-7yoilsho	5119	2	recovery	recovery	NN
cord-006229-7yoilsho	5119	3	was	be	VBD
cord-006229-7yoilsho	5119	4	in	in	IN
cord-006229-7yoilsho	5119	5	the	the	DT
cord-006229-7yoilsho	5119	6	range	range	NN
cord-006229-7yoilsho	5119	7	of	of	IN
cord-006229-7yoilsho	5119	8	90	90	CD
cord-006229-7yoilsho	5119	9	%	%	NN
cord-006229-7yoilsho	5119	10	,	,	,
cord-006229-7yoilsho	5119	11	and	and	CC
cord-006229-7yoilsho	5119	12	significant	significant	JJ
cord-006229-7yoilsho	5119	13	amounts	amount	NNS
cord-006229-7yoilsho	5119	14	of	of	IN
cord-006229-7yoilsho	5119	15	hypericin	hypericin	NNS
cord-006229-7yoilsho	5119	16	found	find	VBN
cord-006229-7yoilsho	5119	17	after	after	IN
cord-006229-7yoilsho	5119	18	cell	cell	NN
cord-006229-7yoilsho	5119	19	extraction	extraction	NN
cord-006229-7yoilsho	5119	20	.	.	.
cord-006229-7yoilsho	5120	1	Fluorescence	fluorescence	NN
cord-006229-7yoilsho	5120	2	microscopy	microscopy	NNS
cord-006229-7yoilsho	5120	3	and	and	CC
cord-006229-7yoilsho	5120	4	imaging	imaging	NN
cord-006229-7yoilsho	5120	5	analysis	analysis	NN
cord-006229-7yoilsho	5120	6	revealed	reveal	VBD
cord-006229-7yoilsho	5120	7	that	that	IN
cord-006229-7yoilsho	5120	8	hypericin	hypericin	NN
cord-006229-7yoilsho	5120	9	is	be	VBZ
cord-006229-7yoilsho	5120	10	mainly	mainly	RB
cord-006229-7yoilsho	5120	11	accumulated	accumulate	VBN
cord-006229-7yoilsho	5120	12	in	in	IN
cord-006229-7yoilsho	5120	13	the	the	DT
cord-006229-7yoilsho	5120	14	cell	cell	NN
cord-006229-7yoilsho	5120	15	membrane	membrane	NN
cord-006229-7yoilsho	5120	16	.	.	.
cord-006229-7yoilsho	5121	1	The	the	DT
cord-006229-7yoilsho	5121	2	precise	precise	JJ
cord-006229-7yoilsho	5121	3	mechanism	mechanism	NN
cord-006229-7yoilsho	5121	4	through	through	IN
cord-006229-7yoilsho	5121	5	which	which	WDT
cord-006229-7yoilsho	5121	6	hypericin	hypericin	NNS
cord-006229-7yoilsho	5121	7	might	may	MD
cord-006229-7yoilsho	5121	8	overcome	overcome	VB
cord-006229-7yoilsho	5121	9	the	the	DT
cord-006229-7yoilsho	5121	10	hydrophobic	hydrophobic	JJ
cord-006229-7yoilsho	5121	11	barrier	barrier	NN
cord-006229-7yoilsho	5121	12	of	of	IN
cord-006229-7yoilsho	5121	13	cell	cell	NN
cord-006229-7yoilsho	5121	14	membranes	membrane	NNS
cord-006229-7yoilsho	5121	15	remains	remain	VBZ
cord-006229-7yoilsho	5121	16	to	to	TO
cord-006229-7yoilsho	5121	17	be	be	VB
cord-006229-7yoilsho	5121	18	elucidated	elucidate	VBN
cord-006229-7yoilsho	5121	19	.	.	.
cord-006229-7yoilsho	5122	1	However	however	RB
cord-006229-7yoilsho	5122	2	,	,	,
cord-006229-7yoilsho	5122	3	our	-PRON-	PRP$
cord-006229-7yoilsho	5122	4	experiments	experiment	NNS
cord-006229-7yoilsho	5122	5	demonstrated	demonstrate	VBD
cord-006229-7yoilsho	5122	6	that	that	IN
cord-006229-7yoilsho	5122	7	the	the	DT
cord-006229-7yoilsho	5122	8	permeation	permeation	NN
cord-006229-7yoilsho	5122	9	characteristics	characteristic	NNS
cord-006229-7yoilsho	5122	10	of	of	IN
cord-006229-7yoilsho	5122	11	hypericin	hypericin	NNS
cord-006229-7yoilsho	5122	12	significantly	significantly	RB
cord-006229-7yoilsho	5122	13	improved	improve	VBN
cord-006229-7yoilsho	5122	14	in	in	IN
cord-006229-7yoilsho	5122	15	presence	presence	NN
cord-006229-7yoilsho	5122	16	of	of	IN
cord-006229-7yoilsho	5122	17	the	the	DT
cord-006229-7yoilsho	5122	18	extract	extract	NN
cord-006229-7yoilsho	5122	19	.	.	.
cord-006229-7yoilsho	5123	1	Background	background	NN
cord-006229-7yoilsho	5123	2	:	:	:
cord-006229-7yoilsho	5124	1	The	the	DT
cord-006229-7yoilsho	5124	2	combination	combination	NN
cord-006229-7yoilsho	5124	3	of	of	IN
cord-006229-7yoilsho	5124	4	gamithromycin	gamithromycin	NNS
cord-006229-7yoilsho	5124	5	(	(	-LRB-
cord-006229-7yoilsho	5124	6	GAM	GAM	NNP
cord-006229-7yoilsho	5124	7	)	)	-RRB-
cord-006229-7yoilsho	5124	8	,	,	,
cord-006229-7yoilsho	5124	9	a	a	DT
cord-006229-7yoilsho	5124	10	novel	novel	JJ
cord-006229-7yoilsho	5124	11	drug	drug	NN
cord-006229-7yoilsho	5124	12	with	with	IN
cord-006229-7yoilsho	5124	13	the	the	DT
cord-006229-7yoilsho	5124	14	big	big	JJ
cord-006229-7yoilsho	5124	15	advantage	advantage	NN
cord-006229-7yoilsho	5124	16	of	of	IN
cord-006229-7yoilsho	5124	17	a	a	DT
cord-006229-7yoilsho	5124	18	once	once	RB
cord-006229-7yoilsho	5124	19	weekly	weekly	JJ
cord-006229-7yoilsho	5124	20	administration	administration	NN
cord-006229-7yoilsho	5124	21	,	,	,
cord-006229-7yoilsho	5124	22	and	and	CC
cord-006229-7yoilsho	5124	23	rifampicin	rifampicin	NNP
cord-006229-7yoilsho	5124	24	(	(	-LRB-
cord-006229-7yoilsho	5124	25	RIF	RIF	NNP
cord-006229-7yoilsho	5124	26	)	)	-RRB-
cord-006229-7yoilsho	5124	27	is	be	VBZ
cord-006229-7yoilsho	5124	28	used	use	VBN
cord-006229-7yoilsho	5124	29	in	in	IN
cord-006229-7yoilsho	5124	30	the	the	DT
cord-006229-7yoilsho	5124	31	treatment	treatment	NN
cord-006229-7yoilsho	5124	32	of	of	IN
cord-006229-7yoilsho	5124	33	lower	low	JJR
cord-006229-7yoilsho	5124	34	airway	airway	NN
cord-006229-7yoilsho	5124	35	disease	disease	NN
cord-006229-7yoilsho	5124	36	in	in	IN
cord-006229-7yoilsho	5124	37	foals	foal	NNS
cord-006229-7yoilsho	5124	38	.	.	.
cord-006229-7yoilsho	5125	1	Both	both	DT
cord-006229-7yoilsho	5125	2	are	be	VBP
cord-006229-7yoilsho	5125	3	effective	effective	JJ
cord-006229-7yoilsho	5125	4	in	in	IN
cord-006229-7yoilsho	5125	5	the	the	DT
cord-006229-7yoilsho	5125	6	therapy	therapy	NN
cord-006229-7yoilsho	5125	7	of	of	IN
cord-006229-7yoilsho	5125	8	infections	infection	NNS
cord-006229-7yoilsho	5125	9	with	with	IN
cord-006229-7yoilsho	5125	10	Rhodococcus	Rhodococcus	NNP
cord-006229-7yoilsho	5125	11	equi	equi	NN
cord-006229-7yoilsho	5125	12	,	,	,
cord-006229-7yoilsho	5125	13	a	a	DT
cord-006229-7yoilsho	5125	14	gram	gram	NN
cord-006229-7yoilsho	5125	15	-	-	HYPH
cord-006229-7yoilsho	5125	16	positive	positive	JJ
cord-006229-7yoilsho	5125	17	coccobacillus	coccobacillus	NN
cord-006229-7yoilsho	5125	18	bacterium	bacterium	NN
cord-006229-7yoilsho	5125	19	,	,	,
cord-006229-7yoilsho	5125	20	which	which	WDT
cord-006229-7yoilsho	5125	21	is	be	VBZ
cord-006229-7yoilsho	5125	22	known	know	VBN
cord-006229-7yoilsho	5125	23	to	to	TO
cord-006229-7yoilsho	5125	24	survive	survive	VB
cord-006229-7yoilsho	5125	25	and	and	CC
cord-006229-7yoilsho	5125	26	reproduce	reproduce	VB
cord-006229-7yoilsho	5125	27	within	within	IN
cord-006229-7yoilsho	5125	28	alveolar	alveolar	JJ
cord-006229-7yoilsho	5125	29	macrophages	macrophage	NNS
cord-006229-7yoilsho	5125	30	.	.	.
cord-006229-7yoilsho	5126	1	Macrolides	macrolide	NNS
cord-006229-7yoilsho	5126	2	are	be	VBP
cord-006229-7yoilsho	5126	3	combined	combine	VBN
cord-006229-7yoilsho	5126	4	with	with	IN
cord-006229-7yoilsho	5126	5	RIF	RIF	NNP
cord-006229-7yoilsho	5126	6	to	to	TO
cord-006229-7yoilsho	5126	7	prevent	prevent	VB
cord-006229-7yoilsho	5126	8	resistance	resistance	NN
cord-006229-7yoilsho	5126	9	developing	develop	VBG
cord-006229-7yoilsho	5126	10	with	with	IN
cord-006229-7yoilsho	5126	11	single	single	JJ
cord-006229-7yoilsho	5126	12	agent	agent	NN
cord-006229-7yoilsho	5126	13	therapy	therapy	NN
cord-006229-7yoilsho	5126	14	.	.	.
cord-006229-7yoilsho	5127	1	Both	both	DT
cord-006229-7yoilsho	5127	2	drug	drug	NN
cord-006229-7yoilsho	5127	3	classes	class	NNS
cord-006229-7yoilsho	5127	4	reach	reach	VBP
cord-006229-7yoilsho	5127	5	high	high	JJ
cord-006229-7yoilsho	5127	6	concentrations	concentration	NNS
cord-006229-7yoilsho	5127	7	in	in	IN
cord-006229-7yoilsho	5127	8	the	the	DT
cord-006229-7yoilsho	5127	9	lung	lung	NN
cord-006229-7yoilsho	5127	10	,	,	,
cord-006229-7yoilsho	5127	11	penetrate	penetrate	VB
cord-006229-7yoilsho	5127	12	into	into	IN
cord-006229-7yoilsho	5127	13	phagocytes	phagocyte	NNS
cord-006229-7yoilsho	5127	14	and	and	CC
cord-006229-7yoilsho	5127	15	kill	kill	VB
cord-006229-7yoilsho	5127	16	intracellular	intracellular	JJ
cord-006229-7yoilsho	5127	17	pathogens	pathogen	NNS
cord-006229-7yoilsho	5127	18	.	.	.
cord-006229-7yoilsho	5128	1	Methods	method	NNS
cord-006229-7yoilsho	5128	2	:	:	:
cord-006229-7yoilsho	5129	1	A	a	DT
cord-006229-7yoilsho	5129	2	controlled	control	VBN
cord-006229-7yoilsho	5129	3	,	,	,
cord-006229-7yoilsho	5129	4	single	single	JJ
cord-006229-7yoilsho	5129	5	-	-	HYPH
cord-006229-7yoilsho	5129	6	and	and	CC
cord-006229-7yoilsho	5129	7	multiple	multiple	JJ
cord-006229-7yoilsho	5129	8	dose	dose	NN
cord-006229-7yoilsho	5129	9	study	study	NN
cord-006229-7yoilsho	5129	10	with	with	IN
cord-006229-7yoilsho	5129	11	four	four	CD
cord-006229-7yoilsho	5129	12	-	-	HYPH
cord-006229-7yoilsho	5129	13	periods	period	NNS
cord-006229-7yoilsho	5129	14	was	be	VBD
cord-006229-7yoilsho	5129	15	conducted	conduct	VBN
cord-006229-7yoilsho	5129	16	in	in	IN
cord-006229-7yoilsho	5129	17	10	10	CD
cord-006229-7yoilsho	5129	18	healthy	healthy	JJ
cord-006229-7yoilsho	5129	19	foals	foal	NNS
cord-006229-7yoilsho	5129	20	(	(	-LRB-
cord-006229-7yoilsho	5129	21	5	5	CD
cord-006229-7yoilsho	5129	22	♂	♂	NNP
cord-006229-7yoilsho	5129	23	and	and	CC
cord-006229-7yoilsho	5129	24	5	5	CD
cord-006229-7yoilsho	5129	25	♀	♀	NN
cord-006229-7yoilsho	5129	26	,	,	,
cord-006229-7yoilsho	5129	27	age	age	NN
cord-006229-7yoilsho	5129	28	:	:	:
cord-006229-7yoilsho	5129	29	42	42	CD
cord-006229-7yoilsho	5129	30	-	-	SYM
cord-006229-7yoilsho	5129	31	63	63	CD
cord-006229-7yoilsho	5129	32	days	day	NNS
cord-006229-7yoilsho	5129	33	,	,	,
cord-006229-7yoilsho	5129	34	body	body	NN
cord-006229-7yoilsho	5129	35	weight	weight	NN
cord-006229-7yoilsho	5129	36	:	:	:
cord-006229-7yoilsho	5129	37	100	100	CD
cord-006229-7yoilsho	5129	38	-	-	SYM
cord-006229-7yoilsho	5129	39	177	177	CD
cord-006229-7yoilsho	5129	40	kg	kg	NNS
cord-006229-7yoilsho	5129	41	)	)	-RRB-
cord-006229-7yoilsho	5129	42	which	which	WDT
cord-006229-7yoilsho	5129	43	were	be	VBD
cord-006229-7yoilsho	5129	44	treated	treat	VBN
cord-006229-7yoilsho	5129	45	once	once	RB
cord-006229-7yoilsho	5129	46	with	with	IN
cord-006229-7yoilsho	5129	47	RIF	RIF	NNP
cord-006229-7yoilsho	5129	48	alone	alone	JJ
cord-006229-7yoilsho	5130	1	(	(	-LRB-
cord-006229-7yoilsho	5130	2	10	10	CD
cord-006229-7yoilsho	5130	3	mg	mg	NNP
cord-006229-7yoilsho	5130	4	/	/	SYM
cord-006229-7yoilsho	5130	5	kg	kg	NNP
cord-006229-7yoilsho	5130	6	s.i.d	s.i.d	NNP
cord-006229-7yoilsho	5130	7	.	.	NNP
cord-006229-7yoilsho	5130	8	,	,	,
cord-006229-7yoilsho	5130	9	p.o	p.o	NNP
cord-006229-7yoilsho	5130	10	.	.	NNP
cord-006229-7yoilsho	5130	11	,	,	,
cord-006229-7yoilsho	5130	12	A	a	LS
cord-006229-7yoilsho	5130	13	)	)	-RRB-
cord-006229-7yoilsho	5130	14	followed	follow	VBN
cord-006229-7yoilsho	5130	15	by	by	IN
cord-006229-7yoilsho	5130	16	the	the	DT
cord-006229-7yoilsho	5130	17	administration	administration	NN
cord-006229-7yoilsho	5130	18	of	of	IN
cord-006229-7yoilsho	5130	19	GAM	GAM	NNP
cord-006229-7yoilsho	5131	1	(	(	-LRB-
cord-006229-7yoilsho	5131	2	6	6	CD
cord-006229-7yoilsho	5131	3	mg	mg	NNP
cord-006229-7yoilsho	5131	4	/	/	SYM
cord-006229-7yoilsho	5131	5	kg	kg	NNP
cord-006229-7yoilsho	5131	6	once	once	RB
cord-006229-7yoilsho	5131	7	weekly	weekly	RB
cord-006229-7yoilsho	5131	8	,	,	,
cord-006229-7yoilsho	5131	9	i.v	i.v	NNP
cord-006229-7yoilsho	5131	10	.	.	NNP
cord-006229-7yoilsho	5131	11	,	,	,
cord-006229-7yoilsho	5131	12	B	B	NNP
cord-006229-7yoilsho	5131	13	)	)	-RRB-
cord-006229-7yoilsho	5131	14	for	for	IN
cord-006229-7yoilsho	5131	15	3	3	CD
cord-006229-7yoilsho	5131	16	weeks	week	NNS
cord-006229-7yoilsho	5131	17	.	.	.
cord-006229-7yoilsho	5132	1	Study	study	NN
cord-006229-7yoilsho	5132	2	period	period	NN
cord-006229-7yoilsho	5132	3	3	3	CD
cord-006229-7yoilsho	5132	4	(	(	-LRB-
cord-006229-7yoilsho	5132	5	"	"	``
cord-006229-7yoilsho	5132	6	RIF	RIF	NNP
cord-006229-7yoilsho	5132	7	-	-	HYPH
cord-006229-7yoilsho	5132	8	GAM	GAM	NNP
cord-006229-7yoilsho	5132	9	acute	acute	NN
cord-006229-7yoilsho	5132	10	"	"	''
cord-006229-7yoilsho	5132	11	,	,	,
cord-006229-7yoilsho	5132	12	C	C	NNP
cord-006229-7yoilsho	5132	13	)	)	-RRB-
cord-006229-7yoilsho	5132	14	includes	include	VBZ
cord-006229-7yoilsho	5132	15	the	the	DT
cord-006229-7yoilsho	5132	16	administration	administration	NN
cord-006229-7yoilsho	5132	17	of	of	IN
cord-006229-7yoilsho	5132	18	GAM	GAM	NNP
cord-006229-7yoilsho	5132	19	and	and	CC
cord-006229-7yoilsho	5132	20	RIF	RIF	NNP
cord-006229-7yoilsho	5132	21	for	for	IN
cord-006229-7yoilsho	5132	22	7	7	CD
cord-006229-7yoilsho	5132	23	days	day	NNS
cord-006229-7yoilsho	5132	24	with	with	IN
cord-006229-7yoilsho	5132	25	an	an	DT
cord-006229-7yoilsho	5132	26	administration	administration	NN
cord-006229-7yoilsho	5132	27	interruption	interruption	NN
cord-006229-7yoilsho	5132	28	after	after	IN
cord-006229-7yoilsho	5132	29	the	the	DT
cord-006229-7yoilsho	5132	30	first	first	JJ
cord-006229-7yoilsho	5132	31	RIF	RIF	NNP
cord-006229-7yoilsho	5132	32	dose	dose	NN
cord-006229-7yoilsho	5132	33	for	for	IN
cord-006229-7yoilsho	5132	34	blood	blood	NN
cord-006229-7yoilsho	5132	35	sampling	sampling	NN
cord-006229-7yoilsho	5132	36	.	.	.
cord-006229-7yoilsho	5133	1	For	for	IN
cord-006229-7yoilsho	5133	2	the	the	DT
cord-006229-7yoilsho	5133	3	last	last	JJ
cord-006229-7yoilsho	5133	4	study	study	NN
cord-006229-7yoilsho	5133	5	period	period	NN
cord-006229-7yoilsho	5133	6	(	(	-LRB-
cord-006229-7yoilsho	5133	7	"	"	``
cord-006229-7yoilsho	5133	8	RIF	RIF	NNP
cord-006229-7yoilsho	5133	9	-	-	HYPH
cord-006229-7yoilsho	5133	10	GAM	GAM	NNP
cord-006229-7yoilsho	5133	11	chronic	chronic	NN
cord-006229-7yoilsho	5133	12	"	"	''
cord-006229-7yoilsho	5133	13	,	,	,
cord-006229-7yoilsho	5133	14	D	D	NNP
cord-006229-7yoilsho	5133	15	)	)	-RRB-
cord-006229-7yoilsho	5133	16	both	both	CC
cord-006229-7yoilsho	5133	17	GAM	GAM	NNP
cord-006229-7yoilsho	5133	18	and	and	CC
cord-006229-7yoilsho	5133	19	RIF	RIF	NNP
cord-006229-7yoilsho	5133	20	were	be	VBD
cord-006229-7yoilsho	5133	21	coadministered	coadministere	VBN
cord-006229-7yoilsho	5133	22	for	for	IN
cord-006229-7yoilsho	5133	23	2	2	CD
cord-006229-7yoilsho	5133	24	weeks	week	NNS
cord-006229-7yoilsho	5133	25	.	.	.
cord-006229-7yoilsho	5134	1	All	all	DT
cord-006229-7yoilsho	5134	2	periods	period	NNS
cord-006229-7yoilsho	5134	3	were	be	VBD
cord-006229-7yoilsho	5134	4	completed	complete	VBN
cord-006229-7yoilsho	5134	5	with	with	IN
cord-006229-7yoilsho	5134	6	blood	blood	NN
cord-006229-7yoilsho	5134	7	sampling	sampling	NN
cord-006229-7yoilsho	5134	8	for	for	IN
cord-006229-7yoilsho	5134	9	pharmacokinetic	pharmacokinetic	JJ
cord-006229-7yoilsho	5134	10	analysis	analysis	NN
cord-006229-7yoilsho	5134	11	for	for	IN
cord-006229-7yoilsho	5134	12	48	48	CD
cord-006229-7yoilsho	5135	1	(	(	-LRB-
cord-006229-7yoilsho	5135	2	.	.	.
cord-006229-7yoilsho	5136	1	RIF	RIF	NNP
cord-006229-7yoilsho	5136	2	is	be	VBZ
cord-006229-7yoilsho	5136	3	also	also	RB
cord-006229-7yoilsho	5136	4	accumulated	accumulate	VBN
cord-006229-7yoilsho	5136	5	in	in	IN
cord-006229-7yoilsho	5136	6	the	the	DT
cord-006229-7yoilsho	5136	7	lung	lung	NN
cord-006229-7yoilsho	5136	8	,	,	,
cord-006229-7yoilsho	5136	9	but	but	CC
cord-006229-7yoilsho	5136	10	to	to	IN
cord-006229-7yoilsho	5136	11	a	a	DT
cord-006229-7yoilsho	5136	12	much	much	RB
cord-006229-7yoilsho	5136	13	lower	low	JJR
cord-006229-7yoilsho	5136	14	degree	degree	NN
cord-006229-7yoilsho	5136	15	than	than	IN
cord-006229-7yoilsho	5136	16	GAM	GAM	NNP
cord-006229-7yoilsho	5136	17	(	(	-LRB-
cord-006229-7yoilsho	5136	18	ELF	ELF	NNP
cord-006229-7yoilsho	5136	19	/	/	SYM
cord-006229-7yoilsho	5136	20	C	C	NNP
cord-006229-7yoilsho	5136	21	24	24	CD
cord-006229-7yoilsho	5136	22	h	h	NN
cord-006229-7yoilsho	5136	23	:	:	:
cord-006229-7yoilsho	5136	24	1.2	1.2	CD
cord-006229-7yoilsho	5136	25	±	±	CD
cord-006229-7yoilsho	5136	26	0.5	0.5	CD
cord-006229-7yoilsho	5136	27	;	;	.
cord-006229-7yoilsho	5137	1	BALC	BALC	NNP
cord-006229-7yoilsho	5137	2	/	/	SYM
cord-006229-7yoilsho	5137	3	C	C	NNP
cord-006229-7yoilsho	5137	4	24	24	CD
cord-006229-7yoilsho	5137	5	h	h	NN
cord-006229-7yoilsho	5137	6	:	:	:
cord-006229-7yoilsho	5137	7	2.01	2.01	CD
cord-006229-7yoilsho	5137	8	±	±	CD
cord-006229-7yoilsho	5137	9	1.24	1.24	CD
cord-006229-7yoilsho	5137	10	)	)	-RRB-
cord-006229-7yoilsho	5137	11	.	.	.
cord-006229-7yoilsho	5138	1	Conclusion	conclusion	NN
cord-006229-7yoilsho	5138	2	:	:	:
cord-006229-7yoilsho	5138	3	Pharmacokinetic	pharmacokinetic	JJ
cord-006229-7yoilsho	5138	4	data	datum	NNS
cord-006229-7yoilsho	5138	5	of	of	IN
cord-006229-7yoilsho	5138	6	the	the	DT
cord-006229-7yoilsho	5138	7	present	present	JJ
cord-006229-7yoilsho	5138	8	study	study	NN
cord-006229-7yoilsho	5138	9	provides	provide	VBZ
cord-006229-7yoilsho	5138	10	surprising	surprising	JJ
cord-006229-7yoilsho	5138	11	results	result	NNS
cord-006229-7yoilsho	5138	12	.	.	.
cord-006229-7yoilsho	5139	1	In	in	IN
cord-006229-7yoilsho	5139	2	previous	previous	JJ
cord-006229-7yoilsho	5139	3	studies	study	NNS
cord-006229-7yoilsho	5139	4	coadministration	coadministration	NNP
cord-006229-7yoilsho	5139	5	of	of	IN
cord-006229-7yoilsho	5139	6	clarithromycin	clarithromycin	NNP
cord-006229-7yoilsho	5139	7	and	and	CC
cord-006229-7yoilsho	5139	8	RIF	RIF	NNP
cord-006229-7yoilsho	5139	9	show	show	VBP
cord-006229-7yoilsho	5139	10	a	a	DT
cord-006229-7yoilsho	5139	11	dramatic	dramatic	JJ
cord-006229-7yoilsho	5139	12	decreased	decrease	VBN
cord-006229-7yoilsho	5139	13	plasma	plasma	NN
cord-006229-7yoilsho	5139	14	exposure	exposure	NN
cord-006229-7yoilsho	5139	15	of	of	IN
cord-006229-7yoilsho	5139	16	the	the	DT
cord-006229-7yoilsho	5139	17	macrolide	macrolide	NN
cord-006229-7yoilsho	5139	18	,	,	,
cord-006229-7yoilsho	5139	19	whereas	whereas	IN
cord-006229-7yoilsho	5139	20	the	the	DT
cord-006229-7yoilsho	5139	21	BALC	BALC	NNP
cord-006229-7yoilsho	5139	22	/	/	SYM
cord-006229-7yoilsho	5139	23	C	C	NNP
cord-006229-7yoilsho	5139	24	24	24	CD
cord-006229-7yoilsho	5139	25	h	h	NN
cord-006229-7yoilsho	5139	26	-ratio	-ratio	NN
cord-006229-7yoilsho	5139	27	was	be	VBD
cord-006229-7yoilsho	5139	28	unaffected	unaffected	JJ
cord-006229-7yoilsho	5140	1	(	(	-LRB-
cord-006229-7yoilsho	5140	2	Peters	Peters	NNP
cord-006229-7yoilsho	5140	3	et	et	NNP
cord-006229-7yoilsho	5140	4	al	al	NNP
cord-006229-7yoilsho	5140	5	.	.	NNP
cord-006229-7yoilsho	5140	6	2011	2011	CD
cord-006229-7yoilsho	5140	7	)	)	-RRB-
cord-006229-7yoilsho	5140	8	.	.	.
cord-006229-7yoilsho	5141	1	In	in	IN
cord-006229-7yoilsho	5141	2	contrast	contrast	NN
cord-006229-7yoilsho	5141	3	,	,	,
cord-006229-7yoilsho	5141	4	systemic	systemic	JJ
cord-006229-7yoilsho	5141	5	exposure	exposure	NN
cord-006229-7yoilsho	5141	6	of	of	IN
cord-006229-7yoilsho	5141	7	GAM	GAM	NNP
cord-006229-7yoilsho	5141	8	increase	increase	VB
cord-006229-7yoilsho	5141	9	significantly	significantly	RB
cord-006229-7yoilsho	5141	10	in	in	IN
cord-006229-7yoilsho	5141	11	case	case	NN
cord-006229-7yoilsho	5141	12	of	of	IN
cord-006229-7yoilsho	5141	13	the	the	DT
cord-006229-7yoilsho	5141	14	combined	combine	VBN
cord-006229-7yoilsho	5141	15	therapy	therapy	NN
cord-006229-7yoilsho	5141	16	and	and	CC
cord-006229-7yoilsho	5141	17	the	the	DT
cord-006229-7yoilsho	5141	18	BALC	BALC	NNP
cord-006229-7yoilsho	5141	19	/	/	SYM
cord-006229-7yoilsho	5141	20	C	C	NNP
cord-006229-7yoilsho	5141	21	24	24	CD
cord-006229-7yoilsho	5141	22	h	h	NN
cord-006229-7yoilsho	5142	1	-ratio	-ratio	NNP
cord-006229-7yoilsho	5142	2	was	be	VBD
cord-006229-7yoilsho	5142	3	nearly	nearly	RB
cord-006229-7yoilsho	5142	4	halved	halve	VBN
cord-006229-7yoilsho	5142	5	.	.	.
cord-006229-7yoilsho	5143	1	Both	both	DT
cord-006229-7yoilsho	5143	2	macrolides	macrolide	NNS
cord-006229-7yoilsho	5143	3	have	have	VBP
cord-006229-7yoilsho	5143	4	in	in	IN
cord-006229-7yoilsho	5143	5	common	common	JJ
cord-006229-7yoilsho	5143	6	,	,	,
cord-006229-7yoilsho	5143	7	that	that	IN
cord-006229-7yoilsho	5143	8	they	-PRON-	PRP
cord-006229-7yoilsho	5143	9	are	be	VBP
cord-006229-7yoilsho	5143	10	intensively	intensively	RB
cord-006229-7yoilsho	5143	11	accumulated	accumulate	VBN
cord-006229-7yoilsho	5143	12	in	in	IN
cord-006229-7yoilsho	5143	13	the	the	DT
cord-006229-7yoilsho	5143	14	lung	lung	NN
cord-006229-7yoilsho	5143	15	(	(	-LRB-
cord-006229-7yoilsho	5143	16	ELF	ELF	NNP
cord-006229-7yoilsho	5143	17	<	<	XX
cord-006229-7yoilsho	5143	18	<	<	XX
cord-006229-7yoilsho	5143	19	BALC	BALC	NNP
cord-006229-7yoilsho	5143	20	)	)	-RRB-
cord-006229-7yoilsho	5143	21	.	.	.
cord-006229-7yoilsho	5144	1	At	at	IN
cord-006229-7yoilsho	5144	2	the	the	DT
cord-006229-7yoilsho	5144	3	moment	moment	NN
cord-006229-7yoilsho	5144	4	there	there	EX
cord-006229-7yoilsho	5144	5	is	be	VBZ
cord-006229-7yoilsho	5144	6	further	further	JJ
cord-006229-7yoilsho	5144	7	research	research	NN
cord-006229-7yoilsho	5144	8	required	require	VBN
cord-006229-7yoilsho	5144	9	(	(	-LRB-
cord-006229-7yoilsho	5144	10	e.g.	e.g.	RB
cord-006229-7yoilsho	5144	11	in	in	IN
cord-006229-7yoilsho	5144	12	vitro	vitro	FW
cord-006229-7yoilsho	5144	13	studies	study	NNS
cord-006229-7yoilsho	5144	14	)	)	-RRB-
cord-006229-7yoilsho	5144	15	for	for	IN
cord-006229-7yoilsho	5144	16	a	a	DT
cord-006229-7yoilsho	5144	17	better	well	JJR
cord-006229-7yoilsho	5144	18	understanding	understanding	NN
cord-006229-7yoilsho	5144	19	of	of	IN
cord-006229-7yoilsho	5144	20	the	the	DT
cord-006229-7yoilsho	5144	21	very	very	RB
cord-006229-7yoilsho	5144	22	interesting	interesting	JJ
cord-006229-7yoilsho	5144	23	in	in	IN
cord-006229-7yoilsho	5144	24	vivo	vivo	NNP
cord-006229-7yoilsho	5144	25	data	datum	NNS
cord-006229-7yoilsho	5144	26	.	.	.
cord-006229-7yoilsho	5145	1	1	1	CD
cord-006229-7yoilsho	5145	2	1	1	CD
cord-006229-7yoilsho	5145	3	Institut	Institut	NNP
cord-006229-7yoilsho	5145	4	für	für	IN
cord-006229-7yoilsho	5145	5	Klinische	Klinische	NNP
cord-006229-7yoilsho	5145	6	Pharmakologie	Pharmakologie	NNP
cord-006229-7yoilsho	5145	7	,	,	,
cord-006229-7yoilsho	5145	8	Göttingen	Göttingen	NNP
cord-006229-7yoilsho	5145	9	,	,	,
cord-006229-7yoilsho	5145	10	Germany	Germany	NNP
cord-006229-7yoilsho	5145	11	Background	Background	NNP
cord-006229-7yoilsho	5145	12	and	and	CC
cord-006229-7yoilsho	5145	13	aim	aim	VB
cord-006229-7yoilsho	5145	14	:	:	:
cord-006229-7yoilsho	5145	15	Desvenlafaxine	Desvenlafaxine	NNP
cord-006229-7yoilsho	5145	16	is	be	VBZ
cord-006229-7yoilsho	5145	17	a	a	DT
cord-006229-7yoilsho	5145	18	selective	selective	JJ
cord-006229-7yoilsho	5145	19	serotonin	serotonin	NN
cord-006229-7yoilsho	5145	20	and	and	CC
cord-006229-7yoilsho	5145	21	norepinephrin	norepinephrin	JJ
cord-006229-7yoilsho	5145	22	reuptake	reuptake	JJ
cord-006229-7yoilsho	5145	23	inhibitor	inhibitor	NN
cord-006229-7yoilsho	5145	24	,	,	,
cord-006229-7yoilsho	5145	25	which	which	WDT
cord-006229-7yoilsho	5145	26	is	be	VBZ
cord-006229-7yoilsho	5145	27	approved	approve	VBN
cord-006229-7yoilsho	5145	28	in	in	IN
cord-006229-7yoilsho	5145	29	the	the	DT
cord-006229-7yoilsho	5145	30	USA	USA	NNP
cord-006229-7yoilsho	5145	31	(	(	-LRB-
cord-006229-7yoilsho	5145	32	but	but	CC
cord-006229-7yoilsho	5145	33	not	not	RB
cord-006229-7yoilsho	5145	34	in	in	IN
cord-006229-7yoilsho	5145	35	Europe	Europe	NNP
cord-006229-7yoilsho	5145	36	)	)	-RRB-
cord-006229-7yoilsho	5145	37	for	for	IN
cord-006229-7yoilsho	5145	38	treatment	treatment	NN
cord-006229-7yoilsho	5145	39	of	of	IN
cord-006229-7yoilsho	5145	40	major	major	JJ
cord-006229-7yoilsho	5145	41	depressive	depressive	JJ
cord-006229-7yoilsho	5145	42	disorder	disorder	NN
cord-006229-7yoilsho	5145	43	.	.	.
cord-006229-7yoilsho	5146	1	Desvenlafaxine	Desvenlafaxine	NNP
cord-006229-7yoilsho	5146	2	is	be	VBZ
cord-006229-7yoilsho	5146	3	the	the	DT
cord-006229-7yoilsho	5146	4	major	major	JJ
cord-006229-7yoilsho	5146	5	active	active	JJ
cord-006229-7yoilsho	5146	6	metabolite	metabolite	NN
cord-006229-7yoilsho	5146	7	of	of	IN
cord-006229-7yoilsho	5146	8	the	the	DT
cord-006229-7yoilsho	5146	9	antidepressant	antidepressant	JJ
cord-006229-7yoilsho	5146	10	venlafaxine	venlafaxine	NN
cord-006229-7yoilsho	5146	11	.	.	.
cord-006229-7yoilsho	5147	1	Desvenlafaxin	Desvenlafaxin	NNP
cord-006229-7yoilsho	5147	2	is	be	VBZ
cord-006229-7yoilsho	5147	3	produced	produce	VBN
cord-006229-7yoilsho	5147	4	by	by	IN
cord-006229-7yoilsho	5147	5	O	o	NN
cord-006229-7yoilsho	5147	6	-	-	HYPH
cord-006229-7yoilsho	5147	7	desmethylation	desmethylation	NN
cord-006229-7yoilsho	5147	8	via	via	IN
cord-006229-7yoilsho	5147	9	CYP2D6	CYP2D6	NNP
cord-006229-7yoilsho	5147	10	.	.	.
cord-006229-7yoilsho	5148	1	Direct	direct	JJ
cord-006229-7yoilsho	5148	2	administration	administration	NN
cord-006229-7yoilsho	5148	3	of	of	IN
cord-006229-7yoilsho	5148	4	desvenlafaxine	desvenlafaxine	NNP
cord-006229-7yoilsho	5148	5	should	should	MD
cord-006229-7yoilsho	5148	6	bypass	bypass	VB
cord-006229-7yoilsho	5148	7	the	the	DT
cord-006229-7yoilsho	5148	8	variability	variability	NN
cord-006229-7yoilsho	5148	9	in	in	IN
cord-006229-7yoilsho	5148	10	venlafaxine	venlafaxine	NNP
cord-006229-7yoilsho	5148	11	pharmacokinetics	pharmacokinetic	NNS
cord-006229-7yoilsho	5148	12	caused	cause	VBN
cord-006229-7yoilsho	5148	13	by	by	IN
cord-006229-7yoilsho	5148	14	the	the	DT
cord-006229-7yoilsho	5148	15	highly	highly	RB
cord-006229-7yoilsho	5148	16	polymorphic	polymorphic	JJ
cord-006229-7yoilsho	5148	17	CYP2D6	CYP2D6	NNP
cord-006229-7yoilsho	5148	18	.	.	.
cord-006229-7yoilsho	5149	1	However	however	RB
cord-006229-7yoilsho	5149	2	,	,	,
cord-006229-7yoilsho	5149	3	desvenlafaxine	desvenlafaxine	NNP
cord-006229-7yoilsho	5149	4	is	be	VBZ
cord-006229-7yoilsho	5149	5	less	less	RBR
cord-006229-7yoilsho	5149	6	lipophilic	lipophilic	JJ
cord-006229-7yoilsho	5149	7	than	than	IN
cord-006229-7yoilsho	5149	8	venlafaxine	venlafaxine	NN
cord-006229-7yoilsho	5149	9	and	and	CC
cord-006229-7yoilsho	5149	10	may	may	MD
cord-006229-7yoilsho	5149	11	require	require	VB
cord-006229-7yoilsho	5149	12	carrier	carrier	NN
cord-006229-7yoilsho	5149	13	-	-	HYPH
cord-006229-7yoilsho	5149	14	mediated	mediate	VBN
cord-006229-7yoilsho	5149	15	transport	transport	NN
cord-006229-7yoilsho	5149	16	to	to	TO
cord-006229-7yoilsho	5149	17	penetrate	penetrate	VB
cord-006229-7yoilsho	5149	18	cell	cell	NN
cord-006229-7yoilsho	5149	19	membranes	membrane	NNS
cord-006229-7yoilsho	5149	20	.	.	.
cord-006229-7yoilsho	5150	1	Based	base	VBN
cord-006229-7yoilsho	5150	2	on	on	IN
cord-006229-7yoilsho	5150	3	our	-PRON-	PRP$
cord-006229-7yoilsho	5150	4	in	in	FW
cord-006229-7yoilsho	5150	5	vitro	vitro	FW
cord-006229-7yoilsho	5150	6	data	datum	NNS
cord-006229-7yoilsho	5150	7	,	,	,
cord-006229-7yoilsho	5150	8	desvenlafaxine	desvenlafaxine	NNP
cord-006229-7yoilsho	5150	9	is	be	VBZ
cord-006229-7yoilsho	5150	10	a	a	DT
cord-006229-7yoilsho	5150	11	substrate	substrate	NN
cord-006229-7yoilsho	5150	12	of	of	IN
cord-006229-7yoilsho	5150	13	the	the	DT
cord-006229-7yoilsho	5150	14	hepatic	hepatic	JJ
cord-006229-7yoilsho	5150	15	organic	organic	JJ
cord-006229-7yoilsho	5150	16	cation	cation	NN
cord-006229-7yoilsho	5150	17	transporter	transporter	NN
cord-006229-7yoilsho	5150	18	OCT1	OCT1	NNP
cord-006229-7yoilsho	5150	19	and	and	CC
cord-006229-7yoilsho	5150	20	common	common	JJ
cord-006229-7yoilsho	5150	21	genetic	genetic	JJ
cord-006229-7yoilsho	5150	22	polymorphisms	polymorphism	NNS
cord-006229-7yoilsho	5150	23	abolished	abolish	VBD
cord-006229-7yoilsho	5150	24	desvenlafaxine	desvenlafaxine	JJ
cord-006229-7yoilsho	5150	25	cellular	cellular	JJ
cord-006229-7yoilsho	5150	26	uptake	uptake	NN
cord-006229-7yoilsho	5150	27	.	.	.
cord-006229-7yoilsho	5151	1	About	about	IN
cord-006229-7yoilsho	5151	2	9	9	CD
cord-006229-7yoilsho	5151	3	%	%	NN
cord-006229-7yoilsho	5151	4	of	of	IN
cord-006229-7yoilsho	5151	5	Caucasians	Caucasians	NNPS
cord-006229-7yoilsho	5151	6	are	be	VBP
cord-006229-7yoilsho	5151	7	compound	compound	JJ
cord-006229-7yoilsho	5151	8	heterozygous	heterozygous	JJ
cord-006229-7yoilsho	5151	9	carriers	carrier	NNS
cord-006229-7yoilsho	5151	10	of	of	IN
cord-006229-7yoilsho	5151	11	loss	loss	NN
cord-006229-7yoilsho	5151	12	-	-	HYPH
cord-006229-7yoilsho	5151	13	of	of	IN
cord-006229-7yoilsho	5151	14	-	-	HYPH
cord-006229-7yoilsho	5151	15	function	function	NN
cord-006229-7yoilsho	5151	16	OCT1	OCT1	NNP
cord-006229-7yoilsho	5151	17	polymorphisms	polymorphism	NNS
cord-006229-7yoilsho	5151	18	.	.	.
cord-006229-7yoilsho	5152	1	Therefore	therefore	RB
cord-006229-7yoilsho	5152	2	,	,	,
cord-006229-7yoilsho	5152	3	OCT1	OCT1	NNP
cord-006229-7yoilsho	5152	4	polymorphisms	polymorphism	NNS
cord-006229-7yoilsho	5152	5	may	may	MD
cord-006229-7yoilsho	5152	6	cause	cause	VB
cord-006229-7yoilsho	5152	7	substantial	substantial	JJ
cord-006229-7yoilsho	5152	8	inter	inter	JJ
cord-006229-7yoilsho	5152	9	-	-	JJ
cord-006229-7yoilsho	5152	10	individual	individual	JJ
cord-006229-7yoilsho	5152	11	variability	variability	NN
cord-006229-7yoilsho	5152	12	in	in	IN
cord-006229-7yoilsho	5152	13	the	the	DT
cord-006229-7yoilsho	5152	14	hepatic	hepatic	JJ
cord-006229-7yoilsho	5152	15	uptake	uptake	NN
cord-006229-7yoilsho	5152	16	and	and	CC
cord-006229-7yoilsho	5152	17	plasma	plasma	NN
cord-006229-7yoilsho	5152	18	concentrations	concentration	NNS
cord-006229-7yoilsho	5152	19	of	of	IN
cord-006229-7yoilsho	5152	20	desvenlafaxine	desvenlafaxine	NN
cord-006229-7yoilsho	5152	21	.	.	.
cord-006229-7yoilsho	5153	1	In	in	IN
cord-006229-7yoilsho	5153	2	this	this	DT
cord-006229-7yoilsho	5153	3	study	study	NN
cord-006229-7yoilsho	5153	4	we	-PRON-	PRP
cord-006229-7yoilsho	5153	5	evaluated	evaluate	VBD
cord-006229-7yoilsho	5153	6	the	the	DT
cord-006229-7yoilsho	5153	7	influence	influence	NN
cord-006229-7yoilsho	5153	8	of	of	IN
cord-006229-7yoilsho	5153	9	genetically	genetically	RB
cord-006229-7yoilsho	5153	10	-	-	HYPH
cord-006229-7yoilsho	5153	11	determined	determine	VBN
cord-006229-7yoilsho	5153	12	loss	loss	NN
cord-006229-7yoilsho	5153	13	of	of	IN
cord-006229-7yoilsho	5153	14	OCT1	OCT1	NNP
cord-006229-7yoilsho	5153	15	function	function	NN
cord-006229-7yoilsho	5153	16	on	on	IN
cord-006229-7yoilsho	5153	17	the	the	DT
cord-006229-7yoilsho	5153	18	pharmacokinetics	pharmacokinetic	NNS
cord-006229-7yoilsho	5153	19	and	and	CC
cord-006229-7yoilsho	5153	20	pharmacodynamics	pharmacodynamic	NNS
cord-006229-7yoilsho	5153	21	of	of	IN
cord-006229-7yoilsho	5153	22	desvenlafaxine	desvenlafaxine	NNP
cord-006229-7yoilsho	5153	23	.	.	.
cord-006229-7yoilsho	5154	1	Primary	primary	JJ
cord-006229-7yoilsho	5154	2	aim	aim	NN
cord-006229-7yoilsho	5154	3	was	be	VBD
cord-006229-7yoilsho	5154	4	dependence	dependence	NN
cord-006229-7yoilsho	5154	5	of	of	IN
cord-006229-7yoilsho	5154	6	desvenlafaxine	desvenlafaxine	JJ
cord-006229-7yoilsho	5154	7	plasma	plasma	NN
cord-006229-7yoilsho	5154	8	concentrations	concentration	NNS
cord-006229-7yoilsho	5154	9	(	(	-LRB-
cord-006229-7yoilsho	5154	10	represented	represent	VBN
cord-006229-7yoilsho	5154	11	by	by	IN
cord-006229-7yoilsho	5154	12	AUC	AUC	NNP
cord-006229-7yoilsho	5154	13	as	as	IN
cord-006229-7yoilsho	5154	14	primary	primary	JJ
cord-006229-7yoilsho	5154	15	endpoint	endpoint	NN
cord-006229-7yoilsho	5154	16	)	)	-RRB-
cord-006229-7yoilsho	5154	17	on	on	IN
cord-006229-7yoilsho	5154	18	the	the	DT
cord-006229-7yoilsho	5154	19	number	number	NN
cord-006229-7yoilsho	5154	20	of	of	IN
cord-006229-7yoilsho	5154	21	active	active	JJ
cord-006229-7yoilsho	5154	22	OCT1	OCT1	NNP
cord-006229-7yoilsho	5154	23	alleles	allele	NNS
cord-006229-7yoilsho	5154	24	.	.	.
cord-006229-7yoilsho	5155	1	Methods	method	NNS
cord-006229-7yoilsho	5155	2	:	:	:
cord-006229-7yoilsho	5155	3	50	50	CD
cord-006229-7yoilsho	5155	4	mg	mg	NN
cord-006229-7yoilsho	5155	5	desvenlafaxine	desvenlafaxine	NNP
cord-006229-7yoilsho	5155	6	(	(	-LRB-
cord-006229-7yoilsho	5155	7	Pristiq	Pristiq	NNP
cord-006229-7yoilsho	5155	8	®	®	POS
cord-006229-7yoilsho	5155	9	)	)	-RRB-
cord-006229-7yoilsho	5155	10	was	be	VBD
cord-006229-7yoilsho	5155	11	orally	orally	RB
cord-006229-7yoilsho	5155	12	administered	administer	VBN
cord-006229-7yoilsho	5155	13	to	to	IN
cord-006229-7yoilsho	5155	14	41	41	CD
cord-006229-7yoilsho	5155	15	healthy	healthy	JJ
cord-006229-7yoilsho	5155	16	subjects	subject	NNS
cord-006229-7yoilsho	5155	17	preselected	preselecte	VBN
cord-006229-7yoilsho	5155	18	according	accord	VBG
cord-006229-7yoilsho	5155	19	to	to	IN
cord-006229-7yoilsho	5155	20	their	-PRON-	PRP$
cord-006229-7yoilsho	5155	21	OCT1	OCT1	NNP
cord-006229-7yoilsho	5155	22	genotypes	genotype	NNS
cord-006229-7yoilsho	5155	23	.	.	.
cord-006229-7yoilsho	5156	1	OCT1	OCT1	NNP
cord-006229-7yoilsho	5156	2	*	*	NFP
cord-006229-7yoilsho	5156	3	1	1	CD
cord-006229-7yoilsho	5156	4	allele	allele	NN
cord-006229-7yoilsho	5156	5	was	be	VBD
cord-006229-7yoilsho	5156	6	regarded	regard	VBN
cord-006229-7yoilsho	5156	7	full	full	JJ
cord-006229-7yoilsho	5156	8	active	active	JJ
cord-006229-7yoilsho	5156	9	,	,	,
cord-006229-7yoilsho	5156	10	OCT1	OCT1	NNP
cord-006229-7yoilsho	5156	11	*	*	NFP
cord-006229-7yoilsho	5156	12	2	2	CD
cord-006229-7yoilsho	5156	13	to	to	IN
cord-006229-7yoilsho	5156	14	*	*	CD
cord-006229-7yoilsho	5156	15	6	6	CD
cord-006229-7yoilsho	5156	16	alleles	allele	NNS
cord-006229-7yoilsho	5156	17	were	be	VBD
cord-006229-7yoilsho	5156	18	regarded	regard	VBN
cord-006229-7yoilsho	5156	19	loss	loss	NN
cord-006229-7yoilsho	5156	20	of	of	IN
cord-006229-7yoilsho	5156	21	function	function	NN
cord-006229-7yoilsho	5156	22	.	.	.
cord-006229-7yoilsho	5157	1	Plasma	plasma	NN
cord-006229-7yoilsho	5157	2	concentrations	concentration	NNS
cord-006229-7yoilsho	5157	3	of	of	IN
cord-006229-7yoilsho	5157	4	desvenlafaxine	desvenlafaxine	NN
cord-006229-7yoilsho	5157	5	and	and	CC
cord-006229-7yoilsho	5157	6	its	-PRON-	PRP$
cord-006229-7yoilsho	5157	7	main	main	JJ
cord-006229-7yoilsho	5157	8	metabolite	metabolite	NN
cord-006229-7yoilsho	5157	9	didesmethylvenlafaxine	didesmethylvenlafaxine	NN
cord-006229-7yoilsho	5157	10	were	be	VBD
cord-006229-7yoilsho	5157	11	quantified	quantify	VBN
cord-006229-7yoilsho	5157	12	in	in	IN
cord-006229-7yoilsho	5157	13	plasma	plasma	NN
cord-006229-7yoilsho	5157	14	sampled	sample	VBN
cord-006229-7yoilsho	5157	15	up	up	RP
cord-006229-7yoilsho	5157	16	to	to	TO
cord-006229-7yoilsho	5157	17	60	60	CD
cord-006229-7yoilsho	5157	18	hours	hour	NNS
cord-006229-7yoilsho	5157	19	after	after	IN
cord-006229-7yoilsho	5157	20	administration	administration	NN
cord-006229-7yoilsho	5157	21	using	use	VBG
cord-006229-7yoilsho	5157	22	LC	LC	NNP
cord-006229-7yoilsho	5157	23	-	-	HYPH
cord-006229-7yoilsho	5157	24	MS	MS	NNP
cord-006229-7yoilsho	5157	25	/	/	SYM
cord-006229-7yoilsho	5157	26	MS	MS	NNP
cord-006229-7yoilsho	5157	27	.	.	.
cord-006229-7yoilsho	5158	1	Pupillographic	pupillographic	JJ
cord-006229-7yoilsho	5158	2	measurements	measurement	NNS
cord-006229-7yoilsho	5158	3	were	be	VBD
cord-006229-7yoilsho	5158	4	performed	perform	VBN
cord-006229-7yoilsho	5158	5	as	as	IN
cord-006229-7yoilsho	5158	6	possible	possible	JJ
cord-006229-7yoilsho	5158	7	surrogate	surrogate	JJ
cord-006229-7yoilsho	5158	8	markers	marker	NNS
cord-006229-7yoilsho	5158	9	for	for	IN
cord-006229-7yoilsho	5158	10	desvenlafaxine	desvenlafaxine	JJ
cord-006229-7yoilsho	5158	11	pharmacodynamics	pharmacodynamic	NNS
cord-006229-7yoilsho	5158	12	.	.	.
cord-006229-7yoilsho	5159	1	Results	result	NNS
cord-006229-7yoilsho	5159	2	Out	out	IN
cord-006229-7yoilsho	5159	3	of	of	IN
cord-006229-7yoilsho	5159	4	the	the	DT
cord-006229-7yoilsho	5159	5	41	41	CD
cord-006229-7yoilsho	5159	6	subjects	subject	NNS
cord-006229-7yoilsho	5159	7	14	14	CD
cord-006229-7yoilsho	5159	8	carried	carry	VBD
cord-006229-7yoilsho	5159	9	two	two	CD
cord-006229-7yoilsho	5159	10	active	active	JJ
cord-006229-7yoilsho	5159	11	,	,	,
cord-006229-7yoilsho	5159	12	13	13	CD
cord-006229-7yoilsho	5159	13	one	one	CD
cord-006229-7yoilsho	5159	14	active	active	JJ
cord-006229-7yoilsho	5159	15	,	,	,
cord-006229-7yoilsho	5159	16	and	and	CC
cord-006229-7yoilsho	5159	17	14	14	CD
cord-006229-7yoilsho	5159	18	zero	zero	CD
cord-006229-7yoilsho	5159	19	active	active	JJ
cord-006229-7yoilsho	5159	20	OCT1	OCT1	NNP
cord-006229-7yoilsho	5159	21	alleles	allele	NNS
cord-006229-7yoilsho	5159	22	.	.	.
cord-006229-7yoilsho	5160	1	Age	age	NN
cord-006229-7yoilsho	5160	2	,	,	,
cord-006229-7yoilsho	5160	3	height	height	NN
cord-006229-7yoilsho	5160	4	and	and	CC
cord-006229-7yoilsho	5160	5	weight	weight	NN
cord-006229-7yoilsho	5160	6	were	be	VBD
cord-006229-7yoilsho	5160	7	26.9	26.9	CD
cord-006229-7yoilsho	5160	8	±	±	CD
cord-006229-7yoilsho	5160	9	6.4	6.4	CD
cord-006229-7yoilsho	5160	10	years	year	NNS
cord-006229-7yoilsho	5161	1	(	(	-LRB-
cord-006229-7yoilsho	5161	2	mean	mean	VB
cord-006229-7yoilsho	5161	3	±	±	NNP
cord-006229-7yoilsho	5161	4	standard	standard	JJ
cord-006229-7yoilsho	5161	5	deviation	deviation	NN
cord-006229-7yoilsho	5161	6	)	)	-RRB-
cord-006229-7yoilsho	5161	7	,	,	,
cord-006229-7yoilsho	5161	8	1.75	1.75	CD
cord-006229-7yoilsho	5161	9	±	±	CD
cord-006229-7yoilsho	5161	10	0.11	0.11	CD
cord-006229-7yoilsho	5161	11	m	m	NN
cord-006229-7yoilsho	5161	12	and	and	CC
cord-006229-7yoilsho	5161	13	70.9	70.9	CD
cord-006229-7yoilsho	5161	14	±	±	NNP
cord-006229-7yoilsho	5161	15	12.1	12.1	CD
cord-006229-7yoilsho	5161	16	kg	kg	NNS
cord-006229-7yoilsho	5161	17	with	with	IN
cord-006229-7yoilsho	5161	18	no	no	DT
cord-006229-7yoilsho	5161	19	significant	significant	JJ
cord-006229-7yoilsho	5161	20	differences	difference	NNS
cord-006229-7yoilsho	5161	21	among	among	IN
cord-006229-7yoilsho	5161	22	the	the	DT
cord-006229-7yoilsho	5161	23	OCT1	OCT1	NNP
cord-006229-7yoilsho	5161	24	genotypes	genotype	NNS
cord-006229-7yoilsho	5161	25	.	.	.
cord-006229-7yoilsho	5162	1	There	there	EX
cord-006229-7yoilsho	5162	2	were	be	VBD
cord-006229-7yoilsho	5162	3	strong	strong	JJ
cord-006229-7yoilsho	5162	4	variations	variation	NNS
cord-006229-7yoilsho	5162	5	in	in	IN
cord-006229-7yoilsho	5162	6	the	the	DT
cord-006229-7yoilsho	5162	7	pharmacokinetics	pharmacokinetic	NNS
cord-006229-7yoilsho	5162	8	of	of	IN
cord-006229-7yoilsho	5162	9	desvenlafaxine	desvenlafaxine	NNP
cord-006229-7yoilsho	5162	10	and	and	CC
cord-006229-7yoilsho	5162	11	its	-PRON-	PRP$
cord-006229-7yoilsho	5162	12	metabolite	metabolite	JJ
cord-006229-7yoilsho	5162	13	didesmethylvenlafaxine	didesmethylvenlafaxine	NN
cord-006229-7yoilsho	5162	14	.	.	.
cord-006229-7yoilsho	5163	1	The	the	DT
cord-006229-7yoilsho	5163	2	AUC	AUC	NNP
cord-006229-7yoilsho	5163	3	0-infinity	0-infinity	CD
cord-006229-7yoilsho	5163	4	of	of	IN
cord-006229-7yoilsho	5163	5	desvenlafaxine	desvenlafaxine	NNP
cord-006229-7yoilsho	5163	6	varied	varied	JJ
cord-006229-7yoilsho	5163	7	between	between	IN
cord-006229-7yoilsho	5163	8	52.8	52.8	CD
cord-006229-7yoilsho	5163	9	and	and	CC
cord-006229-7yoilsho	5163	10	282.2	282.2	CD
cord-006229-7yoilsho	5163	11	min*mg	min*mg	NNP
cord-006229-7yoilsho	5163	12	/	/	SYM
cord-006229-7yoilsho	5163	13	L	L	NNP
cord-006229-7yoilsho	5163	14	and	and	CC
cord-006229-7yoilsho	5163	15	AUC	AUC	NNP
cord-006229-7yoilsho	5163	16	0-infinity	0-infinity	NNP
cord-006229-7yoilsho	5163	17	of	of	IN
cord-006229-7yoilsho	5163	18	didesmethylvenlafaxine	didesmethylvenlafaxine	NN
cord-006229-7yoilsho	5163	19	between	between	IN
cord-006229-7yoilsho	5163	20	3.5	3.5	CD
cord-006229-7yoilsho	5163	21	and	and	CC
cord-006229-7yoilsho	5163	22	30.7	30.7	CD
cord-006229-7yoilsho	5163	23	mg*min	mg*min	NNP
cord-006229-7yoilsho	5163	24	/	/	SYM
cord-006229-7yoilsho	5163	25	L.	L.	NNP
cord-006229-7yoilsho	5164	1	However	however	RB
cord-006229-7yoilsho	5164	2	,	,	,
cord-006229-7yoilsho	5164	3	neither	neither	CC
cord-006229-7yoilsho	5164	4	desvenlafaxine	desvenlafaxine	JJ
cord-006229-7yoilsho	5164	5	nor	nor	CC
cord-006229-7yoilsho	5164	6	didesmethylvenlafaxine	didesmethylvenlafaxine	JJ
cord-006229-7yoilsho	5164	7	pharmacokinetics	pharmacokinetics	NNP
cord-006229-7yoilsho	5164	8	significantly	significantly	RB
cord-006229-7yoilsho	5164	9	differed	differ	VBD
cord-006229-7yoilsho	5164	10	among	among	IN
cord-006229-7yoilsho	5164	11	the	the	DT
cord-006229-7yoilsho	5164	12	three	three	CD
cord-006229-7yoilsho	5164	13	OCT1	OCT1	NNP
cord-006229-7yoilsho	5164	14	genotypes	genotype	NNS
cord-006229-7yoilsho	5164	15	.	.	.
cord-006229-7yoilsho	5165	1	Concerning	concern	VBG
cord-006229-7yoilsho	5165	2	pharmacodynamics	pharmacodynamic	NNS
cord-006229-7yoilsho	5165	3	of	of	IN
cord-006229-7yoilsho	5165	4	desvenlafaxine	desvenlafaxine	NN
cord-006229-7yoilsho	5165	5	,	,	,
cord-006229-7yoilsho	5165	6	pupil	pupil	NN
cord-006229-7yoilsho	5165	7	diameters	diameter	NNS
cord-006229-7yoilsho	5165	8	at	at	IN
cord-006229-7yoilsho	5165	9	maximal	maximal	JJ
cord-006229-7yoilsho	5165	10	constriction	constriction	NN
cord-006229-7yoilsho	5165	11	after	after	IN
cord-006229-7yoilsho	5165	12	a	a	DT
cord-006229-7yoilsho	5165	13	standardized	standardized	JJ
cord-006229-7yoilsho	5165	14	light	light	JJ
cord-006229-7yoilsho	5165	15	exposure	exposure	NN
cord-006229-7yoilsho	5165	16	were	be	VBD
cord-006229-7yoilsho	5165	17	on	on	IN
cord-006229-7yoilsho	5165	18	average	average	JJ
cord-006229-7yoilsho	5165	19	14	14	CD
cord-006229-7yoilsho	5165	20	%	%	NN
cord-006229-7yoilsho	5165	21	greater	great	JJR
cord-006229-7yoilsho	5165	22	around	around	IN
cord-006229-7yoilsho	5165	23	the	the	DT
cord-006229-7yoilsho	5165	24	time	time	NN
cord-006229-7yoilsho	5165	25	of	of	IN
cord-006229-7yoilsho	5165	26	t	t	NNP
cord-006229-7yoilsho	5165	27	max	max	NNP
cord-006229-7yoilsho	5165	28	than	than	IN
cord-006229-7yoilsho	5165	29	before	before	IN
cord-006229-7yoilsho	5165	30	administration	administration	NN
cord-006229-7yoilsho	5165	31	.	.	.
cord-006229-7yoilsho	5166	1	In	in	IN
cord-006229-7yoilsho	5166	2	line	line	NN
cord-006229-7yoilsho	5166	3	with	with	IN
cord-006229-7yoilsho	5166	4	the	the	DT
cord-006229-7yoilsho	5166	5	pharmacokinetic	pharmacokinetic	JJ
cord-006229-7yoilsho	5166	6	results	result	NNS
cord-006229-7yoilsho	5166	7	there	there	EX
cord-006229-7yoilsho	5166	8	were	be	VBD
cord-006229-7yoilsho	5166	9	no	no	DT
cord-006229-7yoilsho	5166	10	significant	significant	JJ
cord-006229-7yoilsho	5166	11	differences	difference	NNS
cord-006229-7yoilsho	5166	12	in	in	IN
cord-006229-7yoilsho	5166	13	maximal	maximal	JJ
cord-006229-7yoilsho	5166	14	constriction	constriction	NN
cord-006229-7yoilsho	5166	15	or	or	CC
cord-006229-7yoilsho	5166	16	other	other	JJ
cord-006229-7yoilsho	5166	17	pupillographic	pupillographic	JJ
cord-006229-7yoilsho	5166	18	parameters	parameter	NNS
cord-006229-7yoilsho	5166	19	among	among	IN
cord-006229-7yoilsho	5166	20	the	the	DT
cord-006229-7yoilsho	5166	21	OCT1	OCT1	NNP
cord-006229-7yoilsho	5166	22	genotype	genotype	NN
cord-006229-7yoilsho	5166	23	groups	group	NNS
cord-006229-7yoilsho	5166	24	.	.	.
cord-006229-7yoilsho	5167	1	Conclusions	conclusion	NNS
cord-006229-7yoilsho	5167	2	:	:	:
cord-006229-7yoilsho	5168	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	5168	2	results	result	NNS
cord-006229-7yoilsho	5168	3	suggest	suggest	VBP
cord-006229-7yoilsho	5168	4	that	that	IN
cord-006229-7yoilsho	5168	5	OCT1	OCT1	NNP
cord-006229-7yoilsho	5168	6	genotype	genotype	NN
cord-006229-7yoilsho	5168	7	does	do	VBZ
cord-006229-7yoilsho	5168	8	not	not	RB
cord-006229-7yoilsho	5168	9	affect	affect	VB
cord-006229-7yoilsho	5168	10	the	the	DT
cord-006229-7yoilsho	5168	11	pharmacokinetics	pharmacokinetic	NNS
cord-006229-7yoilsho	5168	12	of	of	IN
cord-006229-7yoilsho	5168	13	desvenlafaxine	desvenlafaxine	NNP
cord-006229-7yoilsho	5168	14	and	and	CC
cord-006229-7yoilsho	5168	15	therefore	therefore	RB
cord-006229-7yoilsho	5168	16	no	no	DT
cord-006229-7yoilsho	5168	17	dose	dose	JJ
cord-006229-7yoilsho	5168	18	adjustment	adjustment	NN
cord-006229-7yoilsho	5168	19	in	in	IN
cord-006229-7yoilsho	5168	20	respect	respect	NN
cord-006229-7yoilsho	5168	21	to	to	IN
cord-006229-7yoilsho	5168	22	OCT1	OCT1	NNP
cord-006229-7yoilsho	5168	23	genotype	genotype	NN
cord-006229-7yoilsho	5168	24	should	should	MD
cord-006229-7yoilsho	5168	25	be	be	VB
cord-006229-7yoilsho	5168	26	considered	consider	VBN
cord-006229-7yoilsho	5168	27	.	.	.
cord-006229-7yoilsho	5169	1	Other	other	JJ
cord-006229-7yoilsho	5169	2	factors	factor	NNS
cord-006229-7yoilsho	5169	3	like	like	IN
cord-006229-7yoilsho	5169	4	renal	renal	JJ
cord-006229-7yoilsho	5169	5	transporters	transporter	NNS
cord-006229-7yoilsho	5169	6	or	or	CC
cord-006229-7yoilsho	5169	7	polymorphic	polymorphic	JJ
cord-006229-7yoilsho	5169	8	glucuronidation	glucuronidation	NN
cord-006229-7yoilsho	5169	9	may	may	MD
cord-006229-7yoilsho	5169	10	explain	explain	VB
cord-006229-7yoilsho	5169	11	the	the	DT
cord-006229-7yoilsho	5169	12	great	great	JJ
cord-006229-7yoilsho	5169	13	variability	variability	NN
cord-006229-7yoilsho	5169	14	in	in	IN
cord-006229-7yoilsho	5169	15	desvenlafaxine	desvenlafaxine	JJ
cord-006229-7yoilsho	5169	16	pharmacokinetics	pharmacokinetic	NNS
cord-006229-7yoilsho	5169	17	.	.	.
cord-006229-7yoilsho	5170	1	Background	background	NN
cord-006229-7yoilsho	5170	2	:	:	:
cord-006229-7yoilsho	5171	1	Cardiovascular	cardiovascular	JJ
cord-006229-7yoilsho	5171	2	disorders	disorder	NNS
cord-006229-7yoilsho	5171	3	and	and	CC
cord-006229-7yoilsho	5171	4	medication	medication	NN
cord-006229-7yoilsho	5171	5	are	be	VBP
cord-006229-7yoilsho	5171	6	highly	highly	RB
cord-006229-7yoilsho	5171	7	prevalent	prevalent	JJ
cord-006229-7yoilsho	5171	8	in	in	IN
cord-006229-7yoilsho	5171	9	elderly	elderly	JJ
cord-006229-7yoilsho	5171	10	(	(	-LRB-
cord-006229-7yoilsho	5171	11	1	1	CD
cord-006229-7yoilsho	5171	12	)	)	-RRB-
cord-006229-7yoilsho	5171	13	.	.	.
cord-006229-7yoilsho	5172	1	Due	due	IN
cord-006229-7yoilsho	5172	2	to	to	IN
cord-006229-7yoilsho	5172	3	age	age	NN
cord-006229-7yoilsho	5172	4	related	related	JJ
cord-006229-7yoilsho	5172	5	changes	change	NNS
cord-006229-7yoilsho	5172	6	in	in	IN
cord-006229-7yoilsho	5172	7	the	the	DT
cord-006229-7yoilsho	5172	8	body	body	NN
cord-006229-7yoilsho	5172	9	,	,	,
cord-006229-7yoilsho	5172	10	the	the	DT
cord-006229-7yoilsho	5172	11	elderly	elderly	JJ
cord-006229-7yoilsho	5172	12	are	be	VBP
cord-006229-7yoilsho	5172	13	particularly	particularly	RB
cord-006229-7yoilsho	5172	14	vulnerable	vulnerable	JJ
cord-006229-7yoilsho	5172	15	to	to	IN
cord-006229-7yoilsho	5172	16	side	side	JJ
cord-006229-7yoilsho	5172	17	effects	effect	NNS
cord-006229-7yoilsho	5172	18	and	and	CC
cord-006229-7yoilsho	5172	19	adverse	adverse	JJ
cord-006229-7yoilsho	5172	20	drug	drug	NN
cord-006229-7yoilsho	5172	21	reactions	reaction	NNS
cord-006229-7yoilsho	5172	22	.	.	.
cord-006229-7yoilsho	5173	1	Some	some	DT
cord-006229-7yoilsho	5173	2	psychotropic	psychotropic	JJ
cord-006229-7yoilsho	5173	3	drugs	drug	NNS
cord-006229-7yoilsho	5173	4	are	be	VBP
cord-006229-7yoilsho	5173	5	linked	link	VBN
cord-006229-7yoilsho	5173	6	with	with	IN
cord-006229-7yoilsho	5173	7	reports	report	NNS
cord-006229-7yoilsho	5173	8	of	of	IN
cord-006229-7yoilsho	5173	9	cardiac	cardiac	JJ
cord-006229-7yoilsho	5173	10	side	side	NN
cord-006229-7yoilsho	5173	11	effects	effect	NNS
cord-006229-7yoilsho	5173	12	.	.	.
cord-006229-7yoilsho	5174	1	Additionally	additionally	RB
cord-006229-7yoilsho	5174	2	,	,	,
cord-006229-7yoilsho	5174	3	some	some	DT
cord-006229-7yoilsho	5174	4	cardiac	cardiac	JJ
cord-006229-7yoilsho	5174	5	drugs	drug	NNS
cord-006229-7yoilsho	5174	6	may	may	MD
cord-006229-7yoilsho	5174	7	also	also	RB
cord-006229-7yoilsho	5174	8	cause	cause	VB
cord-006229-7yoilsho	5174	9	psychiatric	psychiatric	JJ
cord-006229-7yoilsho	5174	10	symptoms	symptom	NNS
cord-006229-7yoilsho	5174	11	.	.	.
cord-006229-7yoilsho	5175	1	Of	of	IN
cord-006229-7yoilsho	5175	2	these	these	DT
cord-006229-7yoilsho	5175	3	,	,	,
cord-006229-7yoilsho	5175	4	angiotensin	angiotensin	NN
cord-006229-7yoilsho	5175	5	converting	convert	VBG
cord-006229-7yoilsho	5175	6	enzyme	enzyme	NN
cord-006229-7yoilsho	5175	7	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	5175	8	,	,	,
cord-006229-7yoilsho	5175	9	beta	beta	NN
cord-006229-7yoilsho	5175	10	blockers	blocker	NNS
cord-006229-7yoilsho	5175	11	,	,	,
cord-006229-7yoilsho	5175	12	methyldopa	methyldopa	NNP
cord-006229-7yoilsho	5175	13	and	and	CC
cord-006229-7yoilsho	5175	14	calcium	calcium	NN
cord-006229-7yoilsho	5175	15	channel	channel	NN
cord-006229-7yoilsho	5175	16	antagonists	antagonist	NNS
cord-006229-7yoilsho	5175	17	can	can	MD
cord-006229-7yoilsho	5175	18	induce	induce	VB
cord-006229-7yoilsho	5175	19	or	or	CC
cord-006229-7yoilsho	5175	20	exacerbate	exacerbate	VB
cord-006229-7yoilsho	5175	21	symptoms	symptom	NNS
cord-006229-7yoilsho	5175	22	of	of	IN
cord-006229-7yoilsho	5175	23	depression	depression	NN
cord-006229-7yoilsho	5175	24	(	(	-LRB-
cord-006229-7yoilsho	5175	25	2	2	CD
cord-006229-7yoilsho	5175	26	)	)	-RRB-
cord-006229-7yoilsho	5175	27	.	.	.
cord-006229-7yoilsho	5176	1	The	the	DT
cord-006229-7yoilsho	5176	2	aim	aim	NN
cord-006229-7yoilsho	5176	3	of	of	IN
cord-006229-7yoilsho	5176	4	this	this	DT
cord-006229-7yoilsho	5176	5	study	study	NN
cord-006229-7yoilsho	5176	6	was	be	VBD
cord-006229-7yoilsho	5176	7	to	to	TO
cord-006229-7yoilsho	5176	8	provide	provide	VB
cord-006229-7yoilsho	5176	9	information	information	NN
cord-006229-7yoilsho	5176	10	on	on	IN
cord-006229-7yoilsho	5176	11	the	the	DT
cord-006229-7yoilsho	5176	12	concomitant	concomitant	JJ
cord-006229-7yoilsho	5176	13	use	use	NN
cord-006229-7yoilsho	5176	14	of	of	IN
cord-006229-7yoilsho	5176	15	cardiovascular	cardiovascular	JJ
cord-006229-7yoilsho	5176	16	drugs	drug	NNS
cord-006229-7yoilsho	5176	17	among	among	IN
cord-006229-7yoilsho	5176	18	elderly	elderly	JJ
cord-006229-7yoilsho	5176	19	patients	patient	NNS
cord-006229-7yoilsho	5176	20	who	who	WP
cord-006229-7yoilsho	5176	21	took	take	VBD
cord-006229-7yoilsho	5176	22	psychotropic	psychotropic	JJ
cord-006229-7yoilsho	5176	23	medication	medication	NN
cord-006229-7yoilsho	5176	24	.	.	.
cord-006229-7yoilsho	5177	1	Methods	method	NNS
cord-006229-7yoilsho	5177	2	:	:	:
cord-006229-7yoilsho	5177	3	We	-PRON-	PRP
cord-006229-7yoilsho	5177	4	conducted	conduct	VBD
cord-006229-7yoilsho	5177	5	a	a	DT
cord-006229-7yoilsho	5177	6	single	single	JJ
cord-006229-7yoilsho	5177	7	-	-	HYPH
cord-006229-7yoilsho	5177	8	center	center	NN
cord-006229-7yoilsho	5177	9	,	,	,
cord-006229-7yoilsho	5177	10	retrospective	retrospective	JJ
cord-006229-7yoilsho	5177	11	study	study	NN
cord-006229-7yoilsho	5177	12	between	between	IN
cord-006229-7yoilsho	5177	13	September	September	NNP
cord-006229-7yoilsho	5177	14	2013	2013	CD
cord-006229-7yoilsho	5177	15	and	and	CC
cord-006229-7yoilsho	5177	16	December	December	NNP
cord-006229-7yoilsho	5177	17	2013	2013	CD
cord-006229-7yoilsho	5177	18	using	use	VBG
cord-006229-7yoilsho	5177	19	the	the	DT
cord-006229-7yoilsho	5177	20	medical	medical	JJ
cord-006229-7yoilsho	5177	21	records	record	NNS
cord-006229-7yoilsho	5177	22	of	of	IN
cord-006229-7yoilsho	5177	23	elderly	elderly	JJ
cord-006229-7yoilsho	5177	24	patients	patient	NNS
cord-006229-7yoilsho	5177	25	(	(	-LRB-
cord-006229-7yoilsho	5177	26	≥65	≥65	IN
cord-006229-7yoilsho	5177	27	years	year	NNS
cord-006229-7yoilsho	5177	28	of	of	IN
cord-006229-7yoilsho	5177	29	age	age	NN
cord-006229-7yoilsho	5177	30	)	)	-RRB-
cord-006229-7yoilsho	5177	31	admitted	admit	VBD
cord-006229-7yoilsho	5177	32	to	to	IN
cord-006229-7yoilsho	5177	33	Basin	Basin	NNP
cord-006229-7yoilsho	5177	34	Sitesi	Sitesi	NNP
cord-006229-7yoilsho	5177	35	Polyclinic	Polyclinic	NNP
cord-006229-7yoilsho	5177	36	,	,	,
cord-006229-7yoilsho	5177	37	Izmir	Izmir	NNP
cord-006229-7yoilsho	5177	38	Ataturk	Ataturk	NNP
cord-006229-7yoilsho	5177	39	Research	Research	NNP
cord-006229-7yoilsho	5177	40	Hospital	Hospital	NNP
cord-006229-7yoilsho	5177	41	,	,	,
cord-006229-7yoilsho	5177	42	Turkey	Turkey	NNP
cord-006229-7yoilsho	5177	43	.	.	.
cord-006229-7yoilsho	5178	1	Demographic	demographic	JJ
cord-006229-7yoilsho	5178	2	characteristics	characteristic	NNS
cord-006229-7yoilsho	5178	3	of	of	IN
cord-006229-7yoilsho	5178	4	patients	patient	NNS
cord-006229-7yoilsho	5178	5	,	,	,
cord-006229-7yoilsho	5178	6	diagnoses	diagnosis	NNS
cord-006229-7yoilsho	5178	7	,	,	,
cord-006229-7yoilsho	5178	8	prescription	prescription	NN
cord-006229-7yoilsho	5178	9	drugs	drug	NNS
cord-006229-7yoilsho	5178	10	were	be	VBD
cord-006229-7yoilsho	5178	11	evaluated	evaluate	VBN
cord-006229-7yoilsho	5178	12	,	,	,
cord-006229-7yoilsho	5178	13	and	and	CC
cord-006229-7yoilsho	5178	14	SPSS	SPSS	NNP
cord-006229-7yoilsho	5178	15	16.0	16.0	CD
cord-006229-7yoilsho	5178	16	statistical	statistical	JJ
cord-006229-7yoilsho	5178	17	software	software	NN
cord-006229-7yoilsho	5178	18	was	be	VBD
cord-006229-7yoilsho	5178	19	used	use	VBN
cord-006229-7yoilsho	5178	20	for	for	IN
cord-006229-7yoilsho	5178	21	data	datum	NNS
cord-006229-7yoilsho	5178	22	analysis	analysis	NN
cord-006229-7yoilsho	5178	23	.	.	.
cord-006229-7yoilsho	5179	1	Number	number	NN
cord-006229-7yoilsho	5179	2	,	,	,
cord-006229-7yoilsho	5179	3	percent	percent	NN
cord-006229-7yoilsho	5179	4	,	,	,
cord-006229-7yoilsho	5179	5	mean	mean	JJ
cord-006229-7yoilsho	5179	6	and	and	CC
cord-006229-7yoilsho	5179	7	standard	standard	JJ
cord-006229-7yoilsho	5179	8	deviation	deviation	NN
cord-006229-7yoilsho	5179	9	were	be	VBD
cord-006229-7yoilsho	5179	10	used	use	VBN
cord-006229-7yoilsho	5179	11	as	as	IN
cord-006229-7yoilsho	5179	12	descriptive	descriptive	JJ
cord-006229-7yoilsho	5179	13	statistics	statistic	NNS
cord-006229-7yoilsho	5179	14	.	.	.
cord-006229-7yoilsho	5180	1	Results	result	NNS
cord-006229-7yoilsho	5180	2	:	:	:
cord-006229-7yoilsho	5181	1	A	a	DT
cord-006229-7yoilsho	5181	2	total	total	NN
cord-006229-7yoilsho	5181	3	of	of	IN
cord-006229-7yoilsho	5181	4	541	541	CD
cord-006229-7yoilsho	5181	5	elderly	elderly	JJ
cord-006229-7yoilsho	5181	6	patients	patient	NNS
cord-006229-7yoilsho	5181	7	with	with	IN
cord-006229-7yoilsho	5181	8	psychiatric	psychiatric	JJ
cord-006229-7yoilsho	5181	9	disorders	disorder	NNS
cord-006229-7yoilsho	5181	10	were	be	VBD
cord-006229-7yoilsho	5181	11	identified	identify	VBN
cord-006229-7yoilsho	5181	12	.	.	.
cord-006229-7yoilsho	5182	1	One	one	CD
cord-006229-7yoilsho	5182	2	in	in	IN
cord-006229-7yoilsho	5182	3	four	four	CD
cord-006229-7yoilsho	5182	4	patients	patient	NNS
cord-006229-7yoilsho	5182	5	receiving	receive	VBG
cord-006229-7yoilsho	5182	6	psychotropic	psychotropic	JJ
cord-006229-7yoilsho	5182	7	medication	medication	NN
cord-006229-7yoilsho	5182	8	took	take	VBD
cord-006229-7yoilsho	5182	9	at	at	RB
cord-006229-7yoilsho	5182	10	least	least	RBS
cord-006229-7yoilsho	5182	11	one	one	CD
cord-006229-7yoilsho	5182	12	cardiovascular	cardiovascular	JJ
cord-006229-7yoilsho	5182	13	agent	agent	NN
cord-006229-7yoilsho	5182	14	concomitantly	concomitantly	RB
cord-006229-7yoilsho	5182	15	(	(	-LRB-
cord-006229-7yoilsho	5182	16	n=135	n=135	NNP
cord-006229-7yoilsho	5182	17	)	)	-RRB-
cord-006229-7yoilsho	5182	18	.	.	.
cord-006229-7yoilsho	5183	1	Median	median	JJ
cord-006229-7yoilsho	5183	2	age	age	NN
cord-006229-7yoilsho	5183	3	was	be	VBD
cord-006229-7yoilsho	5183	4	72	72	CD
cord-006229-7yoilsho	5183	5	(	(	-LRB-
cord-006229-7yoilsho	5183	6	min:65	min:65	NNP
cord-006229-7yoilsho	5183	7	,	,	,
cord-006229-7yoilsho	5183	8	max:98	max:98	NNP
cord-006229-7yoilsho	5183	9	)	)	-RRB-
cord-006229-7yoilsho	5183	10	,	,	,
cord-006229-7yoilsho	5183	11	84	84	CD
cord-006229-7yoilsho	5183	12	patients	patient	NNS
cord-006229-7yoilsho	5183	13	were	be	VBD
cord-006229-7yoilsho	5183	14	female	female	JJ
cord-006229-7yoilsho	5183	15	(	(	-LRB-
cord-006229-7yoilsho	5183	16	62.2	62.2	CD
cord-006229-7yoilsho	5183	17	%	%	NN
cord-006229-7yoilsho	5183	18	)	)	-RRB-
cord-006229-7yoilsho	5183	19	.	.	.
cord-006229-7yoilsho	5184	1	According	accord	VBG
cord-006229-7yoilsho	5184	2	to	to	IN
cord-006229-7yoilsho	5184	3	medical	medical	JJ
cord-006229-7yoilsho	5184	4	records	record	NNS
cord-006229-7yoilsho	5184	5	of	of	IN
cord-006229-7yoilsho	5184	6	135	135	CD
cord-006229-7yoilsho	5184	7	patients	patient	NNS
cord-006229-7yoilsho	5184	8	,	,	,
cord-006229-7yoilsho	5184	9	the	the	DT
cord-006229-7yoilsho	5184	10	most	most	RBS
cord-006229-7yoilsho	5184	11	commonly	commonly	RB
cord-006229-7yoilsho	5184	12	used	use	VBN
cord-006229-7yoilsho	5184	13	drugs	drug	NNS
cord-006229-7yoilsho	5184	14	were	be	VBD
cord-006229-7yoilsho	5184	15	escitalopram	escitalopram	NN
cord-006229-7yoilsho	5184	16	,	,	,
cord-006229-7yoilsho	5184	17	sertraline	sertraline	NN
cord-006229-7yoilsho	5184	18	,	,	,
cord-006229-7yoilsho	5184	19	mirtazapine	mirtazapine	NN
cord-006229-7yoilsho	5184	20	,	,	,
cord-006229-7yoilsho	5184	21	quetiapine	quetiapine	NNP
cord-006229-7yoilsho	5184	22	,	,	,
cord-006229-7yoilsho	5184	23	mianserin	mianserin	NNP
cord-006229-7yoilsho	5184	24	and	and	CC
cord-006229-7yoilsho	5184	25	risperidone	risperidone	NN
cord-006229-7yoilsho	5184	26	.	.	.
cord-006229-7yoilsho	5185	1	The	the	DT
cord-006229-7yoilsho	5185	2	proportion	proportion	NN
cord-006229-7yoilsho	5185	3	of	of	IN
cord-006229-7yoilsho	5185	4	the	the	DT
cord-006229-7yoilsho	5185	5	concomitantly	concomitantly	RB
cord-006229-7yoilsho	5185	6	use	use	NN
cord-006229-7yoilsho	5185	7	of	of	IN
cord-006229-7yoilsho	5185	8	cardiovascular	cardiovascular	JJ
cord-006229-7yoilsho	5185	9	drugs	drug	NNS
cord-006229-7yoilsho	5185	10	was	be	VBD
cord-006229-7yoilsho	5185	11	higher	high	JJR
cord-006229-7yoilsho	5185	12	among	among	IN
cord-006229-7yoilsho	5185	13	the	the	DT
cord-006229-7yoilsho	5185	14	patients	patient	NNS
cord-006229-7yoilsho	5185	15	who	who	WP
cord-006229-7yoilsho	5185	16	took	take	VBD
cord-006229-7yoilsho	5185	17	more	more	JJR
cord-006229-7yoilsho	5185	18	than	than	IN
cord-006229-7yoilsho	5185	19	one	one	CD
cord-006229-7yoilsho	5185	20	psychotropic	psychotropic	JJ
cord-006229-7yoilsho	5185	21	drug	drug	NN
cord-006229-7yoilsho	5185	22	(	(	-LRB-
cord-006229-7yoilsho	5185	23	69.6	69.6	CD
cord-006229-7yoilsho	5185	24	%	%	NN
cord-006229-7yoilsho	5185	25	vs.	vs.	CC
cord-006229-7yoilsho	5185	26	%	%	NN
cord-006229-7yoilsho	5185	27	30.4	30.4	CD
cord-006229-7yoilsho	5185	28	)	)	-RRB-
cord-006229-7yoilsho	5185	29	compared	compare	VBN
cord-006229-7yoilsho	5185	30	to	to	IN
cord-006229-7yoilsho	5185	31	patients	patient	NNS
cord-006229-7yoilsho	5185	32	taking	take	VBG
cord-006229-7yoilsho	5185	33	psychotropic	psychotropic	JJ
cord-006229-7yoilsho	5185	34	monotherapy	monotherapy	NN
cord-006229-7yoilsho	5185	35	.	.	.
cord-006229-7yoilsho	5186	1	A	a	DT
cord-006229-7yoilsho	5186	2	higher	high	JJR
cord-006229-7yoilsho	5186	3	percentage	percentage	NN
cord-006229-7yoilsho	5186	4	of	of	IN
cord-006229-7yoilsho	5186	5	women	woman	NNS
cord-006229-7yoilsho	5186	6	used	use	VBN
cord-006229-7yoilsho	5186	7	diuretics	diuretic	NNS
cord-006229-7yoilsho	5186	8	(	(	-LRB-
cord-006229-7yoilsho	5186	9	65.4	65.4	CD
cord-006229-7yoilsho	5186	10	%	%	NN
cord-006229-7yoilsho	5186	11	vs.	vs.	CC
cord-006229-7yoilsho	5186	12	33.3	33.3	CD
cord-006229-7yoilsho	5186	13	%	%	NN
cord-006229-7yoilsho	5186	14	)	)	-RRB-
cord-006229-7yoilsho	5186	15	and	and	CC
cord-006229-7yoilsho	5186	16	angiotensin	angiotensin	NN
cord-006229-7yoilsho	5186	17	receptor	receptor	NN
cord-006229-7yoilsho	5186	18	blockers	blocker	NNS
cord-006229-7yoilsho	5186	19	(	(	-LRB-
cord-006229-7yoilsho	5186	20	36.9	36.9	CD
cord-006229-7yoilsho	5186	21	%	%	NN
cord-006229-7yoilsho	5186	22	vs.	vs.	CC
cord-006229-7yoilsho	5186	23	23.5	23.5	CD
cord-006229-7yoilsho	5186	24	%	%	NN
cord-006229-7yoilsho	5186	25	)	)	-RRB-
cord-006229-7yoilsho	5186	26	concomitantly	concomitantly	RB
cord-006229-7yoilsho	5186	27	with	with	IN
cord-006229-7yoilsho	5186	28	psychotropic	psychotropic	JJ
cord-006229-7yoilsho	5186	29	drugs	drug	NNS
cord-006229-7yoilsho	5186	30	when	when	WRB
cord-006229-7yoilsho	5186	31	compared	compare	VBN
cord-006229-7yoilsho	5186	32	to	to	IN
cord-006229-7yoilsho	5186	33	men	man	NNS
cord-006229-7yoilsho	5186	34	.	.	.
cord-006229-7yoilsho	5187	1	The	the	DT
cord-006229-7yoilsho	5187	2	proportion	proportion	NN
cord-006229-7yoilsho	5187	3	of	of	IN
cord-006229-7yoilsho	5187	4	men	man	NNS
cord-006229-7yoilsho	5187	5	using	use	VBG
cord-006229-7yoilsho	5187	6	angiotensin	angiotensin	NN
cord-006229-7yoilsho	5187	7	-	-	HYPH
cord-006229-7yoilsho	5187	8	converting	convert	VBG
cord-006229-7yoilsho	5187	9	enzyme	enzyme	NN
cord-006229-7yoilsho	5187	10	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	5187	11	and	and	CC
cord-006229-7yoilsho	5187	12	lipid	lipid	NN
cord-006229-7yoilsho	5187	13	-	-	HYPH
cord-006229-7yoilsho	5187	14	modifying	modify	VBG
cord-006229-7yoilsho	5187	15	agents	agent	NNS
cord-006229-7yoilsho	5187	16	was	be	VBD
cord-006229-7yoilsho	5187	17	higher	high	JJR
cord-006229-7yoilsho	5187	18	than	than	IN
cord-006229-7yoilsho	5187	19	women	woman	NNS
cord-006229-7yoilsho	5187	20	(	(	-LRB-
cord-006229-7yoilsho	5187	21	58.8	58.8	CD
cord-006229-7yoilsho	5187	22	%	%	NN
cord-006229-7yoilsho	5187	23	vs.	vs.	NN
cord-006229-7yoilsho	5187	24	38	38	CD
cord-006229-7yoilsho	5187	25	%	%	NN
cord-006229-7yoilsho	5187	26	,	,	,
cord-006229-7yoilsho	5187	27	68.6	68.6	CD
cord-006229-7yoilsho	5187	28	%	%	NN
cord-006229-7yoilsho	5187	29	vs.	vs.	IN
cord-006229-7yoilsho	5187	30	20.2	20.2	CD
cord-006229-7yoilsho	5187	31	%	%	NN
cord-006229-7yoilsho	5187	32	,	,	,
cord-006229-7yoilsho	5187	33	respectively	respectively	RB
cord-006229-7yoilsho	5187	34	)	)	-RRB-
cord-006229-7yoilsho	5187	35	.	.	.
cord-006229-7yoilsho	5188	1	Conclusions	conclusion	NNS
cord-006229-7yoilsho	5188	2	:	:	:
cord-006229-7yoilsho	5189	1	The	the	DT
cord-006229-7yoilsho	5189	2	world	world	NN
cord-006229-7yoilsho	5189	3	's	's	POS
cord-006229-7yoilsho	5189	4	population	population	NN
cord-006229-7yoilsho	5189	5	is	be	VBZ
cord-006229-7yoilsho	5189	6	ageing	age	VBG
cord-006229-7yoilsho	5189	7	rapidly	rapidly	RB
cord-006229-7yoilsho	5189	8	.	.	.
cord-006229-7yoilsho	5190	1	According	accord	VBG
cord-006229-7yoilsho	5190	2	to	to	IN
cord-006229-7yoilsho	5190	3	World	World	NNP
cord-006229-7yoilsho	5190	4	Health	Health	NNP
cord-006229-7yoilsho	5190	5	Organization	Organization	NNP
cord-006229-7yoilsho	5190	6	,	,	,
cord-006229-7yoilsho	5190	7	over	over	IN
cord-006229-7yoilsho	5190	8	20	20	CD
cord-006229-7yoilsho	5190	9	%	%	NN
cord-006229-7yoilsho	5190	10	of	of	IN
cord-006229-7yoilsho	5190	11	elderly	elderly	JJ
cord-006229-7yoilsho	5190	12	suffer	suffer	VBP
cord-006229-7yoilsho	5190	13	from	from	IN
cord-006229-7yoilsho	5190	14	a	a	DT
cord-006229-7yoilsho	5190	15	psychiatric	psychiatric	JJ
cord-006229-7yoilsho	5190	16	or	or	CC
cord-006229-7yoilsho	5190	17	neurological	neurological	JJ
cord-006229-7yoilsho	5190	18	disorder	disorder	NN
cord-006229-7yoilsho	5190	19	.	.	.
cord-006229-7yoilsho	5191	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	5191	2	data	datum	NNS
cord-006229-7yoilsho	5191	3	showed	show	VBD
cord-006229-7yoilsho	5191	4	that	that	IN
cord-006229-7yoilsho	5191	5	use	use	NN
cord-006229-7yoilsho	5191	6	of	of	IN
cord-006229-7yoilsho	5191	7	cardiovascular	cardiovascular	JJ
cord-006229-7yoilsho	5191	8	drugs	drug	NNS
cord-006229-7yoilsho	5191	9	among	among	IN
cord-006229-7yoilsho	5191	10	elderly	elderly	JJ
cord-006229-7yoilsho	5191	11	patients	patient	NNS
cord-006229-7yoilsho	5191	12	with	with	IN
cord-006229-7yoilsho	5191	13	psychiatric	psychiatric	JJ
cord-006229-7yoilsho	5191	14	disorders	disorder	NNS
cord-006229-7yoilsho	5191	15	was	be	VBD
cord-006229-7yoilsho	5191	16	extensive	extensive	JJ
cord-006229-7yoilsho	5191	17	.	.	.
cord-006229-7yoilsho	5192	1	The	the	DT
cord-006229-7yoilsho	5192	2	effects	effect	NNS
cord-006229-7yoilsho	5192	3	and	and	CC
cord-006229-7yoilsho	5192	4	interactions	interaction	NNS
cord-006229-7yoilsho	5192	5	of	of	IN
cord-006229-7yoilsho	5192	6	these	these	DT
cord-006229-7yoilsho	5192	7	drugs	drug	NNS
cord-006229-7yoilsho	5192	8	should	should	MD
cord-006229-7yoilsho	5192	9	be	be	VB
cord-006229-7yoilsho	5192	10	discussed	discuss	VBN
cord-006229-7yoilsho	5192	11	and	and	CC
cord-006229-7yoilsho	5192	12	carefully	carefully	RB
cord-006229-7yoilsho	5192	13	evaluated	evaluate	VBN
cord-006229-7yoilsho	5192	14	before	before	IN
cord-006229-7yoilsho	5192	15	starting	start	VBG
cord-006229-7yoilsho	5192	16	treatment	treatment	NN
cord-006229-7yoilsho	5192	17	in	in	IN
cord-006229-7yoilsho	5192	18	the	the	DT
cord-006229-7yoilsho	5192	19	elderly	elderly	JJ
cord-006229-7yoilsho	5192	20	.	.	.
cord-006229-7yoilsho	5193	1	Further	further	JJ
cord-006229-7yoilsho	5193	2	studies	study	NNS
cord-006229-7yoilsho	5193	3	focusing	focus	VBG
cord-006229-7yoilsho	5193	4	on	on	IN
cord-006229-7yoilsho	5193	5	drug	drug	NN
cord-006229-7yoilsho	5193	6	use	use	NN
cord-006229-7yoilsho	5193	7	in	in	IN
cord-006229-7yoilsho	5193	8	elderly	elderly	JJ
cord-006229-7yoilsho	5193	9	will	will	MD
cord-006229-7yoilsho	5193	10	increase	increase	VB
cord-006229-7yoilsho	5193	11	the	the	DT
cord-006229-7yoilsho	5193	12	success	success	NN
cord-006229-7yoilsho	5193	13	in	in	IN
cord-006229-7yoilsho	5193	14	geriatric	geriatric	JJ
cord-006229-7yoilsho	5193	15	pharmacotherapy	pharmacotherapy	NN
cord-006229-7yoilsho	5193	16	.	.	.
cord-006229-7yoilsho	5194	1	Since	since	IN
cord-006229-7yoilsho	5194	2	the	the	DT
cord-006229-7yoilsho	5194	3	adoption	adoption	NN
cord-006229-7yoilsho	5194	4	of	of	IN
cord-006229-7yoilsho	5194	5	the	the	DT
cord-006229-7yoilsho	5194	6	ICH	ICH	NNP
cord-006229-7yoilsho	5194	7	E14	E14	NNP
cord-006229-7yoilsho	5194	8	guideline	guideline	NN
cord-006229-7yoilsho	5194	9	[	[	-LRB-
cord-006229-7yoilsho	5194	10	1	1	CD
cord-006229-7yoilsho	5194	11	]	]	-RRB-
cord-006229-7yoilsho	5194	12	,	,	,
cord-006229-7yoilsho	5194	13	the	the	DT
cord-006229-7yoilsho	5194	14	Thorough	Thorough	NNP
cord-006229-7yoilsho	5194	15	QT	qt	NN
cord-006229-7yoilsho	5194	16	(	(	-LRB-
cord-006229-7yoilsho	5194	17	TQT	TQT	NNP
cord-006229-7yoilsho	5194	18	)	)	-RRB-
cord-006229-7yoilsho	5194	19	study	study	NN
cord-006229-7yoilsho	5194	20	has	have	VBZ
cord-006229-7yoilsho	5194	21	become	become	VBN
cord-006229-7yoilsho	5194	22	a	a	DT
cord-006229-7yoilsho	5194	23	standard	standard	JJ
cord-006229-7yoilsho	5194	24	element	element	NN
cord-006229-7yoilsho	5194	25	of	of	IN
cord-006229-7yoilsho	5194	26	clinical	clinical	JJ
cord-006229-7yoilsho	5194	27	drug	drug	NN
cord-006229-7yoilsho	5194	28	development	development	NN
cord-006229-7yoilsho	5194	29	.	.	.
cord-006229-7yoilsho	5195	1	However	however	RB
cord-006229-7yoilsho	5195	2	,	,	,
cord-006229-7yoilsho	5195	3	with	with	IN
cord-006229-7yoilsho	5195	4	the	the	DT
cord-006229-7yoilsho	5195	5	IQ	IQ	NNP
cord-006229-7yoilsho	5195	6	/	/	SYM
cord-006229-7yoilsho	5195	7	CSRC	CSRC	NNP
cord-006229-7yoilsho	5195	8	study	study	NN
cord-006229-7yoilsho	5195	9	[	[	-LRB-
cord-006229-7yoilsho	5195	10	2	2	LS
cord-006229-7yoilsho	5195	11	]	]	-RRB-
cord-006229-7yoilsho	5195	12	the	the	DT
cord-006229-7yoilsho	5195	13	ability	ability	NN
cord-006229-7yoilsho	5195	14	to	to	TO
cord-006229-7yoilsho	5195	15	detect	detect	VB
cord-006229-7yoilsho	5195	16	QTc	QTc	NNS
cord-006229-7yoilsho	5195	17	-	-	HYPH
cord-006229-7yoilsho	5195	18	prolongations	prolongation	NNS
cord-006229-7yoilsho	5195	19	of	of	IN
cord-006229-7yoilsho	5195	20	about	about	RB
cord-006229-7yoilsho	5195	21	10	10	CD
cord-006229-7yoilsho	5195	22	ms	m	NNS
cord-006229-7yoilsho	5195	23	in	in	IN
cord-006229-7yoilsho	5195	24	a	a	DT
cord-006229-7yoilsho	5195	25	Phase	phase	NN
cord-006229-7yoilsho	5195	26	I	-PRON-	PRP
cord-006229-7yoilsho	5195	27	setting	setting	NN
cord-006229-7yoilsho	5195	28	has	have	VBZ
cord-006229-7yoilsho	5195	29	been	be	VBN
cord-006229-7yoilsho	5195	30	demonstrated	demonstrate	VBN
cord-006229-7yoilsho	5195	31	.	.	.
cord-006229-7yoilsho	5196	1	As	as	IN
cord-006229-7yoilsho	5196	2	a	a	DT
cord-006229-7yoilsho	5196	3	consequence	consequence	NN
cord-006229-7yoilsho	5196	4	,	,	,
cord-006229-7yoilsho	5196	5	regulatory	regulatory	JJ
cord-006229-7yoilsho	5196	6	agencies	agency	NNS
cord-006229-7yoilsho	5196	7	have	have	VBP
cord-006229-7yoilsho	5196	8	begun	begin	VBN
cord-006229-7yoilsho	5196	9	to	to	TO
cord-006229-7yoilsho	5196	10	grant	grant	VB
cord-006229-7yoilsho	5196	11	waivers	waiver	NNS
cord-006229-7yoilsho	5196	12	for	for	IN
cord-006229-7yoilsho	5196	13	a	a	DT
cord-006229-7yoilsho	5196	14	TQT	TQT	NNP
cord-006229-7yoilsho	5196	15	study	study	NN
cord-006229-7yoilsho	5196	16	based	base	VBN
cord-006229-7yoilsho	5196	17	on	on	IN
cord-006229-7yoilsho	5196	18	negative	negative	JJ
cord-006229-7yoilsho	5196	19	QT	QT	NNP
cord-006229-7yoilsho	5196	20	findings	finding	NNS
cord-006229-7yoilsho	5196	21	obtained	obtain	VBN
cord-006229-7yoilsho	5196	22	from	from	IN
cord-006229-7yoilsho	5196	23	first	first	JJ
cord-006229-7yoilsho	5196	24	-	-	HYPH
cord-006229-7yoilsho	5196	25	in	in	IN
cord-006229-7yoilsho	5196	26	-	-	HYPH
cord-006229-7yoilsho	5196	27	man	man	NN
cord-006229-7yoilsho	5196	28	studies	study	NNS
cord-006229-7yoilsho	5196	29	.	.	.
cord-006229-7yoilsho	5197	1	A	a	DT
cord-006229-7yoilsho	5197	2	concentration	concentration	NN
cord-006229-7yoilsho	5197	3	-	-	HYPH
cord-006229-7yoilsho	5197	4	response	response	NN
cord-006229-7yoilsho	5197	5	model	model	NN
cord-006229-7yoilsho	5197	6	is	be	VBZ
cord-006229-7yoilsho	5197	7	the	the	DT
cord-006229-7yoilsho	5197	8	key	key	JJ
cord-006229-7yoilsho	5197	9	tool	tool	NN
cord-006229-7yoilsho	5197	10	that	that	WDT
cord-006229-7yoilsho	5197	11	gives	give	VBZ
cord-006229-7yoilsho	5197	12	sufficient	sufficient	JJ
cord-006229-7yoilsho	5197	13	power	power	NN
cord-006229-7yoilsho	5197	14	to	to	IN
cord-006229-7yoilsho	5197	15	an	an	DT
cord-006229-7yoilsho	5197	16	analysis	analysis	NN
cord-006229-7yoilsho	5197	17	based	base	VBN
cord-006229-7yoilsho	5197	18	on	on	IN
cord-006229-7yoilsho	5197	19	data	datum	NNS
cord-006229-7yoilsho	5197	20	from	from	IN
cord-006229-7yoilsho	5197	21	single	single	JJ
cord-006229-7yoilsho	5197	22	or	or	CC
cord-006229-7yoilsho	5197	23	multiple	multiple	JJ
cord-006229-7yoilsho	5197	24	ascending	ascend	VBG
cord-006229-7yoilsho	5197	25	dose	dose	NN
cord-006229-7yoilsho	5197	26	studies	study	NNS
cord-006229-7yoilsho	5197	27	.	.	.
cord-006229-7yoilsho	5198	1	This	this	DT
cord-006229-7yoilsho	5198	2	power	power	NN
cord-006229-7yoilsho	5198	3	has	have	VBZ
cord-006229-7yoilsho	5198	4	been	be	VBN
cord-006229-7yoilsho	5198	5	investigated	investigate	VBN
cord-006229-7yoilsho	5198	6	in	in	IN
cord-006229-7yoilsho	5198	7	subsampling	subsampling	NN
cord-006229-7yoilsho	5198	8	studies	study	NNS
cord-006229-7yoilsho	5198	9	that	that	WDT
cord-006229-7yoilsho	5198	10	simulate	simulate	VBP
cord-006229-7yoilsho	5198	11	situations	situation	NNS
cord-006229-7yoilsho	5198	12	comparable	comparable	JJ
cord-006229-7yoilsho	5198	13	to	to	IN
cord-006229-7yoilsho	5198	14	those	those	DT
cord-006229-7yoilsho	5198	15	encountered	encounter	VBN
cord-006229-7yoilsho	5198	16	in	in	IN
cord-006229-7yoilsho	5198	17	first	first	JJ
cord-006229-7yoilsho	5198	18	-	-	HYPH
cord-006229-7yoilsho	5198	19	in	in	IN
cord-006229-7yoilsho	5198	20	-	-	HYPH
cord-006229-7yoilsho	5198	21	man	man	NN
cord-006229-7yoilsho	5198	22	studies	study	NNS
cord-006229-7yoilsho	5198	23	[	[	-LRB-
cord-006229-7yoilsho	5198	24	3	3	CD
cord-006229-7yoilsho	5198	25	,	,	,
cord-006229-7yoilsho	5198	26	4	4	CD
cord-006229-7yoilsho	5198	27	]	]	-RRB-
cord-006229-7yoilsho	5198	28	.	.	.
cord-006229-7yoilsho	5199	1	Other	other	JJ
cord-006229-7yoilsho	5199	2	topics	topic	NNS
cord-006229-7yoilsho	5199	3	to	to	TO
cord-006229-7yoilsho	5199	4	be	be	VB
cord-006229-7yoilsho	5199	5	addressed	address	VBN
cord-006229-7yoilsho	5199	6	are	be	VBP
cord-006229-7yoilsho	5199	7	the	the	DT
cord-006229-7yoilsho	5199	8	assurance	assurance	NN
cord-006229-7yoilsho	5199	9	of	of	IN
cord-006229-7yoilsho	5199	10	sufficient	sufficient	JJ
cord-006229-7yoilsho	5199	11	quality	quality	NN
cord-006229-7yoilsho	5199	12	of	of	IN
cord-006229-7yoilsho	5199	13	the	the	DT
cord-006229-7yoilsho	5199	14	ECGs	ecg	NNS
cord-006229-7yoilsho	5199	15	obtained	obtain	VBN
cord-006229-7yoilsho	5199	16	,	,	,
cord-006229-7yoilsho	5199	17	in	in	IN
cord-006229-7yoilsho	5199	18	particular	particular	JJ
cord-006229-7yoilsho	5199	19	in	in	IN
cord-006229-7yoilsho	5199	20	doses	dose	NNS
cord-006229-7yoilsho	5199	21	that	that	WDT
cord-006229-7yoilsho	5199	22	cause	cause	VBP
cord-006229-7yoilsho	5199	23	adverse	adverse	JJ
cord-006229-7yoilsho	5199	24	reactions	reaction	NNS
cord-006229-7yoilsho	5199	25	,	,	,
cord-006229-7yoilsho	5199	26	and	and	CC
cord-006229-7yoilsho	5199	27	a	a	DT
cord-006229-7yoilsho	5199	28	replacement	replacement	NN
cord-006229-7yoilsho	5199	29	for	for	IN
cord-006229-7yoilsho	5199	30	the	the	DT
cord-006229-7yoilsho	5199	31	active	active	JJ
cord-006229-7yoilsho	5199	32	control	control	NN
cord-006229-7yoilsho	5199	33	that	that	WDT
cord-006229-7yoilsho	5199	34	is	be	VBZ
cord-006229-7yoilsho	5199	35	part	part	NN
cord-006229-7yoilsho	5199	36	of	of	IN
cord-006229-7yoilsho	5199	37	a	a	DT
cord-006229-7yoilsho	5199	38	TQT	TQT	NNP
cord-006229-7yoilsho	5199	39	study	study	NN
cord-006229-7yoilsho	5199	40	.	.	.
cord-006229-7yoilsho	5200	1	If	if	IN
cord-006229-7yoilsho	5200	2	a	a	DT
cord-006229-7yoilsho	5200	3	model	model	NN
cord-006229-7yoilsho	5200	4	based	base	VBN
cord-006229-7yoilsho	5200	5	statistical	statistical	JJ
cord-006229-7yoilsho	5200	6	analysis	analysis	NN
cord-006229-7yoilsho	5200	7	is	be	VBZ
cord-006229-7yoilsho	5200	8	used	use	VBN
cord-006229-7yoilsho	5200	9	for	for	IN
cord-006229-7yoilsho	5200	10	confirmatory	confirmatory	JJ
cord-006229-7yoilsho	5200	11	inference	inference	NN
cord-006229-7yoilsho	5200	12	,	,	,
cord-006229-7yoilsho	5200	13	it	-PRON-	PRP
cord-006229-7yoilsho	5200	14	must	must	MD
cord-006229-7yoilsho	5200	15	be	be	VB
cord-006229-7yoilsho	5200	16	specified	specify	VBN
cord-006229-7yoilsho	5200	17	in	in	IN
cord-006229-7yoilsho	5200	18	advance	advance	NN
cord-006229-7yoilsho	5200	19	.	.	.
cord-006229-7yoilsho	5201	1	This	this	DT
cord-006229-7yoilsho	5201	2	pre	pre	JJ
cord-006229-7yoilsho	5201	3	-	-	JJ
cord-006229-7yoilsho	5201	4	specification	specification	NN
cord-006229-7yoilsho	5201	5	includes	include	VBZ
cord-006229-7yoilsho	5201	6	tests	test	NNS
cord-006229-7yoilsho	5201	7	to	to	TO
cord-006229-7yoilsho	5201	8	ascertain	ascertain	VB
cord-006229-7yoilsho	5201	9	that	that	IN
cord-006229-7yoilsho	5201	10	the	the	DT
cord-006229-7yoilsho	5201	11	model	model	NN
cord-006229-7yoilsho	5201	12	assumptions	assumption	NNS
cord-006229-7yoilsho	5201	13	are	be	VBP
cord-006229-7yoilsho	5201	14	met	meet	VBN
cord-006229-7yoilsho	5201	15	and	and	CC
cord-006229-7yoilsho	5201	16	alternative	alternative	JJ
cord-006229-7yoilsho	5201	17	methods	method	NNS
cord-006229-7yoilsho	5201	18	to	to	TO
cord-006229-7yoilsho	5201	19	be	be	VB
cord-006229-7yoilsho	5201	20	used	use	VBN
cord-006229-7yoilsho	5201	21	in	in	IN
cord-006229-7yoilsho	5201	22	case	case	NN
cord-006229-7yoilsho	5201	23	they	-PRON-	PRP
cord-006229-7yoilsho	5201	24	are	be	VBP
cord-006229-7yoilsho	5201	25	violated	violate	VBN
cord-006229-7yoilsho	5201	26	.	.	.
cord-006229-7yoilsho	5202	1	In	in	IN
cord-006229-7yoilsho	5202	2	particular	particular	JJ
cord-006229-7yoilsho	5202	3	linearity	linearity	NN
cord-006229-7yoilsho	5202	4	and	and	CC
cord-006229-7yoilsho	5202	5	the	the	DT
cord-006229-7yoilsho	5202	6	absence	absence	NN
cord-006229-7yoilsho	5202	7	of	of	IN
cord-006229-7yoilsho	5202	8	a	a	DT
cord-006229-7yoilsho	5202	9	hysteresis	hysteresis	NN
cord-006229-7yoilsho	5202	10	,	,	,
cord-006229-7yoilsho	5202	11	i.e.	i.e.	FW
cord-006229-7yoilsho	5202	12	a	a	DT
cord-006229-7yoilsho	5202	13	delay	delay	NN
cord-006229-7yoilsho	5202	14	between	between	IN
cord-006229-7yoilsho	5202	15	the	the	DT
cord-006229-7yoilsho	5202	16	drug	drug	NN
cord-006229-7yoilsho	5202	17	concentration	concentration	NN
cord-006229-7yoilsho	5202	18	and	and	CC
cord-006229-7yoilsho	5202	19	the	the	DT
cord-006229-7yoilsho	5202	20	observed	observed	JJ
cord-006229-7yoilsho	5202	21	QT	qt	NN
cord-006229-7yoilsho	5202	22	effect	effect	NN
cord-006229-7yoilsho	5202	23	need	need	NN
cord-006229-7yoilsho	5202	24	to	to	TO
cord-006229-7yoilsho	5202	25	be	be	VB
cord-006229-7yoilsho	5202	26	tested	test	VBN
cord-006229-7yoilsho	5202	27	.	.	.
cord-006229-7yoilsho	5203	1	This	this	DT
cord-006229-7yoilsho	5203	2	is	be	VBZ
cord-006229-7yoilsho	5203	3	an	an	DT
cord-006229-7yoilsho	5203	4	area	area	NN
cord-006229-7yoilsho	5203	5	of	of	IN
cord-006229-7yoilsho	5203	6	active	active	JJ
cord-006229-7yoilsho	5203	7	research	research	NN
cord-006229-7yoilsho	5203	8	.	.	.
cord-006229-7yoilsho	5204	1	In	in	IN
cord-006229-7yoilsho	5204	2	this	this	DT
cord-006229-7yoilsho	5204	3	contribution	contribution	NN
cord-006229-7yoilsho	5204	4	,	,	,
cord-006229-7yoilsho	5204	5	I	-PRON-	PRP
cord-006229-7yoilsho	5204	6	will	will	MD
cord-006229-7yoilsho	5204	7	share	share	VB
cord-006229-7yoilsho	5204	8	current	current	JJ
cord-006229-7yoilsho	5204	9	experience	experience	NN
cord-006229-7yoilsho	5204	10	from	from	IN
cord-006229-7yoilsho	5204	11	a	a	DT
cord-006229-7yoilsho	5204	12	statistical	statistical	JJ
cord-006229-7yoilsho	5204	13	perspective	perspective	NN
cord-006229-7yoilsho	5204	14	,	,	,
cord-006229-7yoilsho	5204	15	both	both	DT
cord-006229-7yoilsho	5204	16	based	base	VBN
cord-006229-7yoilsho	5204	17	on	on	IN
cord-006229-7yoilsho	5204	18	real	real	JJ
cord-006229-7yoilsho	5204	19	data	datum	NNS
cord-006229-7yoilsho	5204	20	and	and	CC
cord-006229-7yoilsho	5204	21	on	on	IN
cord-006229-7yoilsho	5204	22	simulated	simulated	JJ
cord-006229-7yoilsho	5204	23	studies	study	NNS
cord-006229-7yoilsho	5204	24	.	.	.
cord-006229-7yoilsho	5205	1	I	-PRON-	PRP
cord-006229-7yoilsho	5205	2	will	will	MD
cord-006229-7yoilsho	5205	3	also	also	RB
cord-006229-7yoilsho	5205	4	discuss	discuss	VB
cord-006229-7yoilsho	5205	5	critical	critical	JJ
cord-006229-7yoilsho	5205	6	points	point	NNS
cord-006229-7yoilsho	5205	7	in	in	IN
cord-006229-7yoilsho	5205	8	the	the	DT
cord-006229-7yoilsho	5205	9	design	design	NN
cord-006229-7yoilsho	5205	10	of	of	IN
cord-006229-7yoilsho	5205	11	first	first	JJ
cord-006229-7yoilsho	5205	12	-	-	HYPH
cord-006229-7yoilsho	5205	13	in	in	IN
cord-006229-7yoilsho	5205	14	-	-	HYPH
cord-006229-7yoilsho	5205	15	man	man	NN
cord-006229-7yoilsho	5205	16	studies	study	NNS
cord-006229-7yoilsho	5205	17	that	that	WDT
cord-006229-7yoilsho	5205	18	are	be	VBP
cord-006229-7yoilsho	5205	19	intended	intend	VBN
cord-006229-7yoilsho	5205	20	to	to	TO
cord-006229-7yoilsho	5205	21	be	be	VB
cord-006229-7yoilsho	5205	22	used	use	VBN
cord-006229-7yoilsho	5205	23	to	to	TO
cord-006229-7yoilsho	5205	24	obtain	obtain	VB
cord-006229-7yoilsho	5205	25	a	a	DT
cord-006229-7yoilsho	5205	26	waiver	waiver	NN
cord-006229-7yoilsho	5205	27	for	for	IN
cord-006229-7yoilsho	5205	28	a	a	DT
cord-006229-7yoilsho	5205	29	TQT	TQT	NNP
cord-006229-7yoilsho	5205	30	study	study	NN
cord-006229-7yoilsho	5205	31	.	.	.
cord-006229-7yoilsho	5206	1	Human	human	JJ
cord-006229-7yoilsho	5206	2	platelets	platelet	NNS
cord-006229-7yoilsho	5206	3	express	express	VBP
cord-006229-7yoilsho	5206	4	the	the	DT
cord-006229-7yoilsho	5206	5	G	g	NN
cord-006229-7yoilsho	5206	6	-	-	HYPH
cord-006229-7yoilsho	5206	7	protein	protein	NN
cord-006229-7yoilsho	5206	8	-	-	HYPH
cord-006229-7yoilsho	5206	9	coupled	couple	VBN
cord-006229-7yoilsho	5206	10	angiotensin	angiotensin	NN
cord-006229-7yoilsho	5206	11	receptor	receptor	NN
cord-006229-7yoilsho	5206	12	-	-	:
cord-006229-7yoilsho	5206	13	like-1	like-1	NN
cord-006229-7yoilsho	5206	14	(	(	-LRB-
cord-006229-7yoilsho	5206	15	APJ	APJ	NNP
cord-006229-7yoilsho	5206	16	)	)	-RRB-
cord-006229-7yoilsho	5206	17	receptor	receptor	NN
cord-006229-7yoilsho	5206	18	.	.	.
cord-006229-7yoilsho	5207	1	APJ	APJ	NNP
cord-006229-7yoilsho	5207	2	is	be	VBZ
cord-006229-7yoilsho	5207	3	activated	activate	VBN
cord-006229-7yoilsho	5207	4	by	by	IN
cord-006229-7yoilsho	5207	5	apelin	apelin	NNP
cord-006229-7yoilsho	5207	6	,	,	,
cord-006229-7yoilsho	5207	7	which	which	WDT
cord-006229-7yoilsho	5207	8	is	be	VBZ
cord-006229-7yoilsho	5207	9	produced	produce	VBN
cord-006229-7yoilsho	5207	10	as	as	IN
cord-006229-7yoilsho	5207	11	pre	pre	JJ
cord-006229-7yoilsho	5207	12	-	-	JJ
cord-006229-7yoilsho	5207	13	apelin	apelin	JJ
cord-006229-7yoilsho	5207	14	and	and	CC
cord-006229-7yoilsho	5207	15	cleaved	cleave	VBN
cord-006229-7yoilsho	5207	16	into	into	IN
cord-006229-7yoilsho	5207	17	several	several	JJ
cord-006229-7yoilsho	5207	18	bioactive	bioactive	JJ
cord-006229-7yoilsho	5207	19	peptides	peptide	NNS
cord-006229-7yoilsho	5207	20	such	such	JJ
cord-006229-7yoilsho	5207	21	as	as	IN
cord-006229-7yoilsho	5207	22	apelin-12	apelin-12	CD
cord-006229-7yoilsho	5207	23	,	,	,
cord-006229-7yoilsho	5207	24	-13	-13	NNS
cord-006229-7yoilsho	5207	25	and	and	CC
cord-006229-7yoilsho	5207	26	-17	-17	NN
cord-006229-7yoilsho	5207	27	.	.	.
cord-006229-7yoilsho	5208	1	Apelin	Apelin	NNP
cord-006229-7yoilsho	5208	2	and	and	CC
cord-006229-7yoilsho	5208	3	APJ	APJ	NNP
cord-006229-7yoilsho	5208	4	are	be	VBP
cord-006229-7yoilsho	5208	5	expressed	express	VBN
cord-006229-7yoilsho	5208	6	in	in	IN
cord-006229-7yoilsho	5208	7	a	a	DT
cord-006229-7yoilsho	5208	8	variety	variety	NN
cord-006229-7yoilsho	5208	9	of	of	IN
cord-006229-7yoilsho	5208	10	tissues	tissue	NNS
cord-006229-7yoilsho	5208	11	such	such	JJ
cord-006229-7yoilsho	5208	12	as	as	IN
cord-006229-7yoilsho	5208	13	the	the	DT
cord-006229-7yoilsho	5208	14	heart	heart	NN
cord-006229-7yoilsho	5208	15	,	,	,
cord-006229-7yoilsho	5208	16	the	the	DT
cord-006229-7yoilsho	5208	17	vessel	vessel	NN
cord-006229-7yoilsho	5208	18	wall	wall	NN
cord-006229-7yoilsho	5208	19	,	,	,
cord-006229-7yoilsho	5208	20	several	several	JJ
cord-006229-7yoilsho	5208	21	tumor	tumor	NN
cord-006229-7yoilsho	5208	22	types	type	NNS
cord-006229-7yoilsho	5208	23	,	,	,
cord-006229-7yoilsho	5208	24	and	and	CC
cord-006229-7yoilsho	5208	25	in	in	IN
cord-006229-7yoilsho	5208	26	platelets	platelet	NNS
cord-006229-7yoilsho	5208	27	.	.	.
cord-006229-7yoilsho	5209	1	To	to	IN
cord-006229-7yoilsho	5209	2	date	date	NN
cord-006229-7yoilsho	5209	3	,	,	,
cord-006229-7yoilsho	5209	4	there	there	EX
cord-006229-7yoilsho	5209	5	is	be	VBZ
cord-006229-7yoilsho	5209	6	no	no	DT
cord-006229-7yoilsho	5209	7	description	description	NN
cord-006229-7yoilsho	5209	8	or	or	CC
cord-006229-7yoilsho	5209	9	a	a	DT
cord-006229-7yoilsho	5209	10	suggested	suggest	VBN
cord-006229-7yoilsho	5209	11	function	function	NN
cord-006229-7yoilsho	5209	12	of	of	IN
cord-006229-7yoilsho	5209	13	the	the	DT
cord-006229-7yoilsho	5209	14	apelin	apelin	NNP
cord-006229-7yoilsho	5209	15	/	/	SYM
cord-006229-7yoilsho	5209	16	APJ	APJ	NNP
cord-006229-7yoilsho	5209	17	system	system	NN
cord-006229-7yoilsho	5209	18	in	in	IN
cord-006229-7yoilsho	5209	19	platelets	platelet	NNS
cord-006229-7yoilsho	5209	20	to	to	IN
cord-006229-7yoilsho	5209	21	date	date	NN
cord-006229-7yoilsho	5209	22	.	.	.
cord-006229-7yoilsho	5210	1	Here	here	RB
cord-006229-7yoilsho	5210	2	,	,	,
cord-006229-7yoilsho	5210	3	we	-PRON-	PRP
cord-006229-7yoilsho	5210	4	investigate	investigate	VBP
cord-006229-7yoilsho	5210	5	APJ	APJ	NNP
cord-006229-7yoilsho	5210	6	expression	expression	NN
cord-006229-7yoilsho	5210	7	and	and	CC
cord-006229-7yoilsho	5210	8	function	function	NN
cord-006229-7yoilsho	5210	9	in	in	IN
cord-006229-7yoilsho	5210	10	human	human	JJ
cord-006229-7yoilsho	5210	11	platelets	platelet	NNS
cord-006229-7yoilsho	5210	12	.	.	.
cord-006229-7yoilsho	5211	1	Apelin	Apelin	NNP
cord-006229-7yoilsho	5211	2	and	and	CC
cord-006229-7yoilsho	5211	3	APJ	APJ	NNP
cord-006229-7yoilsho	5211	4	expression	expression	NN
cord-006229-7yoilsho	5211	5	were	be	VBD
cord-006229-7yoilsho	5211	6	determined	determine	VBN
cord-006229-7yoilsho	5211	7	in	in	IN
cord-006229-7yoilsho	5211	8	platelet	platelet	NN
cord-006229-7yoilsho	5211	9	-	-	HYPH
cord-006229-7yoilsho	5211	10	rich	rich	JJ
cord-006229-7yoilsho	5211	11	plasma	plasma	NN
cord-006229-7yoilsho	5211	12	from	from	IN
cord-006229-7yoilsho	5211	13	healthy	healthy	JJ
cord-006229-7yoilsho	5211	14	donors	donor	NNS
cord-006229-7yoilsho	5211	15	by	by	IN
cord-006229-7yoilsho	5211	16	immunofluorescence	immunofluorescence	NN
cord-006229-7yoilsho	5211	17	,	,	,
cord-006229-7yoilsho	5211	18	Western	western	JJ
cord-006229-7yoilsho	5211	19	blotting	blotting	NN
cord-006229-7yoilsho	5211	20	and	and	CC
cord-006229-7yoilsho	5211	21	flow	flow	NN
cord-006229-7yoilsho	5211	22	cytometry	cytometry	NN
cord-006229-7yoilsho	5211	23	.	.	.
cord-006229-7yoilsho	5212	1	In	in	IN
cord-006229-7yoilsho	5212	2	a	a	DT
cord-006229-7yoilsho	5212	3	pilot	pilot	NN
cord-006229-7yoilsho	5212	4	study	study	NN
cord-006229-7yoilsho	5212	5	apelin	apelin	NN
cord-006229-7yoilsho	5212	6	and	and	CC
cord-006229-7yoilsho	5212	7	platelet	platelet	NN
cord-006229-7yoilsho	5212	8	APJ	APJ	NNP
cord-006229-7yoilsho	5212	9	expression	expression	NN
cord-006229-7yoilsho	5212	10	were	be	VBD
cord-006229-7yoilsho	5212	11	analyzed	analyze	VBN
cord-006229-7yoilsho	5212	12	in	in	IN
cord-006229-7yoilsho	5212	13	23	23	CD
cord-006229-7yoilsho	5212	14	patients	patient	NNS
cord-006229-7yoilsho	5212	15	with	with	IN
cord-006229-7yoilsho	5212	16	NSTEMI	NSTEMI	NNP
cord-006229-7yoilsho	5212	17	,	,	,
cord-006229-7yoilsho	5212	18	4	4	CD
cord-006229-7yoilsho	5212	19	STEMI	STEMI	NNP
cord-006229-7yoilsho	5212	20	patients	patient	NNS
cord-006229-7yoilsho	5212	21	and	and	CC
cord-006229-7yoilsho	5212	22	14	14	CD
cord-006229-7yoilsho	5212	23	controls	control	NNS
cord-006229-7yoilsho	5212	24	.	.	.
cord-006229-7yoilsho	5213	1	Here	here	RB
cord-006229-7yoilsho	5213	2	,	,	,
cord-006229-7yoilsho	5213	3	platelet	platelet	NN
cord-006229-7yoilsho	5213	4	aggregation	aggregation	NN
cord-006229-7yoilsho	5213	5	was	be	VBD
cord-006229-7yoilsho	5213	6	analyzed	analyze	VBN
cord-006229-7yoilsho	5213	7	by	by	IN
cord-006229-7yoilsho	5213	8	light	light	JJ
cord-006229-7yoilsho	5213	9	transmission	transmission	NN
cord-006229-7yoilsho	5213	10	aggregometry	aggregometry	NN
cord-006229-7yoilsho	5213	11	(	(	-LRB-
cord-006229-7yoilsho	5213	12	LTA	LTA	NNP
cord-006229-7yoilsho	5213	13	)	)	-RRB-
cord-006229-7yoilsho	5213	14	;	;	:
cord-006229-7yoilsho	5213	15	platelet	platelet	NN
cord-006229-7yoilsho	5213	16	CD62	CD62	NNP
cord-006229-7yoilsho	5213	17	and	and	CC
cord-006229-7yoilsho	5213	18	APJ	APJ	NNP
cord-006229-7yoilsho	5213	19	expression	expression	NN
cord-006229-7yoilsho	5213	20	by	by	IN
cord-006229-7yoilsho	5213	21	flow	flow	NN
cord-006229-7yoilsho	5213	22	cytometry	cytometry	NN
cord-006229-7yoilsho	5213	23	and	and	CC
cord-006229-7yoilsho	5213	24	circulating	circulate	VBG
cord-006229-7yoilsho	5213	25	plasma	plasma	NN
cord-006229-7yoilsho	5213	26	apelin	apelin	NN
cord-006229-7yoilsho	5213	27	by	by	IN
cord-006229-7yoilsho	5213	28	ELISA	ELISA	NNP
cord-006229-7yoilsho	5213	29	.	.	.
cord-006229-7yoilsho	5214	1	In	in	IN
cord-006229-7yoilsho	5214	2	resting	rest	VBG
cord-006229-7yoilsho	5214	3	human	human	JJ
cord-006229-7yoilsho	5214	4	platelets	platelet	NNS
cord-006229-7yoilsho	5214	5	,	,	,
cord-006229-7yoilsho	5214	6	APJ	APJ	NNP
cord-006229-7yoilsho	5214	7	receptor	receptor	NN
cord-006229-7yoilsho	5214	8	expression	expression	NN
cord-006229-7yoilsho	5214	9	was	be	VBD
cord-006229-7yoilsho	5214	10	observed	observe	VBN
cord-006229-7yoilsho	5214	11	predominantly	predominantly	RB
cord-006229-7yoilsho	5214	12	in	in	IN
cord-006229-7yoilsho	5214	13	the	the	DT
cord-006229-7yoilsho	5214	14	outer	outer	JJ
cord-006229-7yoilsho	5214	15	cell	cell	NN
cord-006229-7yoilsho	5214	16	membrane	membrane	NN
cord-006229-7yoilsho	5214	17	,	,	,
cord-006229-7yoilsho	5214	18	as	as	IN
cord-006229-7yoilsho	5214	19	determined	determine	VBN
cord-006229-7yoilsho	5214	20	by	by	IN
cord-006229-7yoilsho	5214	21	immunofluorescence	immunofluorescence	NN
cord-006229-7yoilsho	5214	22	staining	staining	NN
cord-006229-7yoilsho	5214	23	and	and	CC
cord-006229-7yoilsho	5214	24	flow	flow	NN
cord-006229-7yoilsho	5214	25	cytometry	cytometry	NN
cord-006229-7yoilsho	5214	26	.	.	.
cord-006229-7yoilsho	5215	1	Activation	activation	NN
cord-006229-7yoilsho	5215	2	with	with	IN
cord-006229-7yoilsho	5215	3	a	a	DT
cord-006229-7yoilsho	5215	4	selective	selective	JJ
cord-006229-7yoilsho	5215	5	thrombin	thrombin	NN
cord-006229-7yoilsho	5215	6	receptor	receptor	NN
cord-006229-7yoilsho	5215	7	-	-	HYPH
cord-006229-7yoilsho	5215	8	activating	activate	VBG
cord-006229-7yoilsho	5215	9	peptide	peptide	NN
cord-006229-7yoilsho	5215	10	(	(	-LRB-
cord-006229-7yoilsho	5215	11	AP1	AP1	NNP
cord-006229-7yoilsho	5215	12	)	)	-RRB-
cord-006229-7yoilsho	5215	13	resulted	result	VBD
cord-006229-7yoilsho	5215	14	in	in	IN
cord-006229-7yoilsho	5215	15	decreased	decrease	VBD
cord-006229-7yoilsho	5215	16	APJ	APJ	NNP
cord-006229-7yoilsho	5215	17	protein	protein	NN
cord-006229-7yoilsho	5215	18	levels	level	NNS
cord-006229-7yoilsho	5215	19	determined	determine	VBN
cord-006229-7yoilsho	5215	20	by	by	IN
cord-006229-7yoilsho	5215	21	Western	western	JJ
cord-006229-7yoilsho	5215	22	blotting	blotting	NN
cord-006229-7yoilsho	5215	23	in	in	IN
cord-006229-7yoilsho	5215	24	platelet	platelet	NN
cord-006229-7yoilsho	5215	25	lysates	lysate	NNS
cord-006229-7yoilsho	5215	26	compared	compare	VBN
cord-006229-7yoilsho	5215	27	to	to	IN
cord-006229-7yoilsho	5215	28	untreated	untreated	JJ
cord-006229-7yoilsho	5215	29	controls	control	NNS
cord-006229-7yoilsho	5215	30	.	.	.
cord-006229-7yoilsho	5216	1	Preincubation	preincubation	NN
cord-006229-7yoilsho	5216	2	of	of	IN
cord-006229-7yoilsho	5216	3	platelets	platelet	NNS
cord-006229-7yoilsho	5216	4	with	with	IN
cord-006229-7yoilsho	5216	5	different	different	JJ
cord-006229-7yoilsho	5216	6	apelin	apelin	NN
cord-006229-7yoilsho	5216	7	isoforms	isoform	NNS
cord-006229-7yoilsho	5216	8	for	for	IN
cord-006229-7yoilsho	5216	9	30	30	CD
cord-006229-7yoilsho	5216	10	sec	sec	NNP
cord-006229-7yoilsho	5216	11	to	to	IN
cord-006229-7yoilsho	5216	12	5	5	CD
cord-006229-7yoilsho	5216	13	min	min	NN
cord-006229-7yoilsho	5216	14	reduced	reduced	JJ
cord-006229-7yoilsho	5216	15	platelet	platelet	NN
cord-006229-7yoilsho	5216	16	aggregation	aggregation	NN
cord-006229-7yoilsho	5216	17	in	in	IN
cord-006229-7yoilsho	5216	18	LTA	LTA	NNP
cord-006229-7yoilsho	5216	19	studies	study	NNS
cord-006229-7yoilsho	5216	20	by	by	IN
cord-006229-7yoilsho	5216	21	up	up	IN
cord-006229-7yoilsho	5216	22	to	to	TO
cord-006229-7yoilsho	5216	23	20	20	CD
cord-006229-7yoilsho	5216	24	%	%	NN
cord-006229-7yoilsho	5216	25	for	for	IN
cord-006229-7yoilsho	5216	26	apelin-17	apelin-17	NN
cord-006229-7yoilsho	5216	27	.	.	.
cord-006229-7yoilsho	5217	1	This	this	DT
cord-006229-7yoilsho	5217	2	effect	effect	NN
cord-006229-7yoilsho	5217	3	was	be	VBD
cord-006229-7yoilsho	5217	4	inhibited	inhibit	VBN
cord-006229-7yoilsho	5217	5	by	by	IN
cord-006229-7yoilsho	5217	6	preincubation	preincubation	NN
cord-006229-7yoilsho	5217	7	of	of	IN
cord-006229-7yoilsho	5217	8	the	the	DT
cord-006229-7yoilsho	5217	9	platelets	platelet	NNS
cord-006229-7yoilsho	5217	10	with	with	IN
cord-006229-7yoilsho	5217	11	the	the	DT
cord-006229-7yoilsho	5217	12	eNOS	enos	JJ
cord-006229-7yoilsho	5217	13	inhibitor	inhibitor	NN
cord-006229-7yoilsho	5217	14	L	L	NNP
cord-006229-7yoilsho	5217	15	-	-	HYPH
cord-006229-7yoilsho	5217	16	NAME	NAME	NNP
cord-006229-7yoilsho	5217	17	(	(	-LRB-
cord-006229-7yoilsho	5217	18	300	300	CD
cord-006229-7yoilsho	5217	19	µM	µM	NNP
cord-006229-7yoilsho	5217	20	)	)	-RRB-
cord-006229-7yoilsho	5217	21	,	,	,
cord-006229-7yoilsho	5217	22	suggesting	suggest	VBG
cord-006229-7yoilsho	5217	23	the	the	DT
cord-006229-7yoilsho	5217	24	involvement	involvement	NN
cord-006229-7yoilsho	5217	25	of	of	IN
cord-006229-7yoilsho	5217	26	a	a	DT
cord-006229-7yoilsho	5217	27	NO	no	JJ
cord-006229-7yoilsho	5217	28	-	-	HYPH
cord-006229-7yoilsho	5217	29	dependent	dependent	JJ
cord-006229-7yoilsho	5217	30	mechanism	mechanism	NN
cord-006229-7yoilsho	5217	31	.	.	.
cord-006229-7yoilsho	5218	1	In	in	IN
cord-006229-7yoilsho	5218	2	patients	patient	NNS
cord-006229-7yoilsho	5218	3	with	with	IN
cord-006229-7yoilsho	5218	4	myocardial	myocardial	JJ
cord-006229-7yoilsho	5218	5	infarction	infarction	NN
cord-006229-7yoilsho	5218	6	the	the	DT
cord-006229-7yoilsho	5218	7	expression	expression	NN
cord-006229-7yoilsho	5218	8	of	of	IN
cord-006229-7yoilsho	5218	9	platelet	platelet	NN
cord-006229-7yoilsho	5218	10	APJ	APJ	NNP
cord-006229-7yoilsho	5218	11	was	be	VBD
cord-006229-7yoilsho	5218	12	significantly	significantly	RB
cord-006229-7yoilsho	5218	13	reduced	reduce	VBN
cord-006229-7yoilsho	5218	14	compared	compare	VBN
cord-006229-7yoilsho	5218	15	to	to	IN
cord-006229-7yoilsho	5218	16	the	the	DT
cord-006229-7yoilsho	5218	17	control	control	NN
cord-006229-7yoilsho	5218	18	group	group	NN
cord-006229-7yoilsho	5218	19	(	(	-LRB-
cord-006229-7yoilsho	5218	20	56,84	56,84	CD
cord-006229-7yoilsho	5218	21	%	%	NN
cord-006229-7yoilsho	5218	22	±	±	NNP
cord-006229-7yoilsho	5218	23	9,28	9,28	CD
cord-006229-7yoilsho	5218	24	%	%	NN
cord-006229-7yoilsho	5218	25	in	in	IN
cord-006229-7yoilsho	5218	26	MI	MI	NNP
cord-006229-7yoilsho	5218	27	versus	versus	IN
cord-006229-7yoilsho	5218	28	100	100	CD
cord-006229-7yoilsho	5218	29	%	%	NN
cord-006229-7yoilsho	5218	30	±	±	NNP
cord-006229-7yoilsho	5218	31	19,35	19,35	CD
cord-006229-7yoilsho	5218	32	%	%	NN
cord-006229-7yoilsho	5218	33	in	in	IN
cord-006229-7yoilsho	5218	34	controls	control	NNS
cord-006229-7yoilsho	5218	35	;	;	:
cord-006229-7yoilsho	5218	36	p	p	NN
cord-006229-7yoilsho	5218	37	=	=	SYM
cord-006229-7yoilsho	5218	38	0.029	0.029	CD
cord-006229-7yoilsho	5218	39	)	)	-RRB-
cord-006229-7yoilsho	5218	40	.	.	.
cord-006229-7yoilsho	5219	1	This	this	DT
cord-006229-7yoilsho	5219	2	reduction	reduction	NN
cord-006229-7yoilsho	5219	3	in	in	IN
cord-006229-7yoilsho	5219	4	APJ	APJ	NNP
cord-006229-7yoilsho	5219	5	expression	expression	NN
cord-006229-7yoilsho	5219	6	on	on	IN
cord-006229-7yoilsho	5219	7	platelets	platelet	NNS
cord-006229-7yoilsho	5219	8	was	be	VBD
cord-006229-7yoilsho	5219	9	accompanied	accompany	VBN
cord-006229-7yoilsho	5219	10	by	by	IN
cord-006229-7yoilsho	5219	11	decreased	decreased	JJ
cord-006229-7yoilsho	5219	12	plasma	plasma	NN
cord-006229-7yoilsho	5219	13	levels	level	NNS
cord-006229-7yoilsho	5219	14	of	of	IN
cord-006229-7yoilsho	5219	15	apelin-17	apelin-17	NN
cord-006229-7yoilsho	5219	16	in	in	IN
cord-006229-7yoilsho	5219	17	patients	patient	NNS
cord-006229-7yoilsho	5219	18	with	with	IN
cord-006229-7yoilsho	5219	19	MI	MI	NNP
cord-006229-7yoilsho	5219	20	(	(	-LRB-
cord-006229-7yoilsho	5219	21	14.95	14.95	CD
cord-006229-7yoilsho	5219	22	±	±	NNP
cord-006229-7yoilsho	5219	23	0.6	0.6	CD
cord-006229-7yoilsho	5219	24	pg	pg	NN
cord-006229-7yoilsho	5219	25	/	/	SYM
cord-006229-7yoilsho	5219	26	mL	ml	NN
cord-006229-7yoilsho	5219	27	versus	versus	IN
cord-006229-7yoilsho	5219	28	16.98	16.98	CD
cord-006229-7yoilsho	5219	29	±	±	NNP
cord-006229-7yoilsho	5219	30	0.6	0.6	CD
cord-006229-7yoilsho	5219	31	pg	pg	NN
cord-006229-7yoilsho	5219	32	/	/	SYM
cord-006229-7yoilsho	5219	33	mL	ml	NN
cord-006229-7yoilsho	5219	34	;	;	:
cord-006229-7yoilsho	5219	35	p	p	NN
cord-006229-7yoilsho	5219	36	=	=	SYM
cord-006229-7yoilsho	5219	37	0.035	0.035	CD
cord-006229-7yoilsho	5219	38	)	)	-RRB-
cord-006229-7yoilsho	5219	39	.	.	.
cord-006229-7yoilsho	5220	1	Interestingly	interestingly	RB
cord-006229-7yoilsho	5220	2	,	,	,
cord-006229-7yoilsho	5220	3	the	the	DT
cord-006229-7yoilsho	5220	4	decreased	decrease	VBD
cord-006229-7yoilsho	5220	5	APJ	APJ	NNP
cord-006229-7yoilsho	5220	6	expression	expression	NN
cord-006229-7yoilsho	5220	7	on	on	IN
cord-006229-7yoilsho	5220	8	platelets	platelet	NNS
cord-006229-7yoilsho	5220	9	in	in	IN
cord-006229-7yoilsho	5220	10	MI	MI	NNP
cord-006229-7yoilsho	5220	11	patients	patient	NNS
cord-006229-7yoilsho	5220	12	significantly	significantly	RB
cord-006229-7yoilsho	5220	13	correlated	correlate	VBD
cord-006229-7yoilsho	5220	14	inversely	inversely	RB
cord-006229-7yoilsho	5220	15	with	with	IN
cord-006229-7yoilsho	5220	16	the	the	DT
cord-006229-7yoilsho	5220	17	troponin	troponin	JJ
cord-006229-7yoilsho	5220	18	T	t	NN
cord-006229-7yoilsho	5220	19	plasma	plasma	NN
cord-006229-7yoilsho	5220	20	levels	level	NNS
cord-006229-7yoilsho	5220	21	(	(	-LRB-
cord-006229-7yoilsho	5220	22	r	r	NN
cord-006229-7yoilsho	5220	23	=	=	NN
cord-006229-7yoilsho	5220	24	-0.46	-0.46	VBN
cord-006229-7yoilsho	5220	25	;	;	:
cord-006229-7yoilsho	5220	26	p	p	NN
cord-006229-7yoilsho	5220	27	=	=	SYM
cord-006229-7yoilsho	5220	28	0.03	0.03	CD
cord-006229-7yoilsho	5220	29	)	)	-RRB-
cord-006229-7yoilsho	5220	30	.	.	.
cord-006229-7yoilsho	5221	1	This	this	DT
cord-006229-7yoilsho	5221	2	may	may	MD
cord-006229-7yoilsho	5221	3	suggest	suggest	VB
cord-006229-7yoilsho	5221	4	an	an	DT
cord-006229-7yoilsho	5221	5	association	association	NN
cord-006229-7yoilsho	5221	6	of	of	IN
cord-006229-7yoilsho	5221	7	APJ	APJ	NNP
cord-006229-7yoilsho	5221	8	expression	expression	NN
cord-006229-7yoilsho	5221	9	with	with	IN
cord-006229-7yoilsho	5221	10	lower	low	JJR
cord-006229-7yoilsho	5221	11	plasma	plasma	NN
cord-006229-7yoilsho	5221	12	levels	level	NNS
cord-006229-7yoilsho	5221	13	of	of	IN
cord-006229-7yoilsho	5221	14	troponin	troponin	JJ
cord-006229-7yoilsho	5221	15	T	t	NN
cord-006229-7yoilsho	5221	16	and	and	CC
cord-006229-7yoilsho	5221	17	possibly	possibly	RB
cord-006229-7yoilsho	5221	18	tissue	tissue	VB
cord-006229-7yoilsho	5221	19	damage	damage	NN
cord-006229-7yoilsho	5221	20	.	.	.
cord-006229-7yoilsho	5222	1	In	in	IN
cord-006229-7yoilsho	5222	2	conclusion	conclusion	NN
cord-006229-7yoilsho	5222	3	,	,	,
cord-006229-7yoilsho	5222	4	our	-PRON-	PRP$
cord-006229-7yoilsho	5222	5	study	study	NN
cord-006229-7yoilsho	5222	6	shows	show	VBZ
cord-006229-7yoilsho	5222	7	for	for	IN
cord-006229-7yoilsho	5222	8	the	the	DT
cord-006229-7yoilsho	5222	9	first	first	JJ
cord-006229-7yoilsho	5222	10	time	time	NN
cord-006229-7yoilsho	5222	11	the	the	DT
cord-006229-7yoilsho	5222	12	expression	expression	NN
cord-006229-7yoilsho	5222	13	of	of	IN
cord-006229-7yoilsho	5222	14	APJ	APJ	NNP
cord-006229-7yoilsho	5222	15	and	and	CC
cord-006229-7yoilsho	5222	16	a	a	DT
cord-006229-7yoilsho	5222	17	possible	possible	JJ
cord-006229-7yoilsho	5222	18	function	function	NN
cord-006229-7yoilsho	5222	19	in	in	IN
cord-006229-7yoilsho	5222	20	human	human	JJ
cord-006229-7yoilsho	5222	21	platelets	platelet	NNS
cord-006229-7yoilsho	5222	22	.	.	.
cord-006229-7yoilsho	5223	1	APJ	APJ	NNP
cord-006229-7yoilsho	5223	2	may	may	MD
cord-006229-7yoilsho	5223	3	act	act	VB
cord-006229-7yoilsho	5223	4	as	as	IN
cord-006229-7yoilsho	5223	5	an	an	DT
cord-006229-7yoilsho	5223	6	endogenous	endogenous	JJ
cord-006229-7yoilsho	5223	7	inhibitor	inhibitor	NN
cord-006229-7yoilsho	5223	8	of	of	IN
cord-006229-7yoilsho	5223	9	platelet	platelet	NN
cord-006229-7yoilsho	5223	10	aggregation	aggregation	NN
cord-006229-7yoilsho	5223	11	in	in	IN
cord-006229-7yoilsho	5223	12	response	response	NN
cord-006229-7yoilsho	5223	13	to	to	IN
cord-006229-7yoilsho	5223	14	certain	certain	JJ
cord-006229-7yoilsho	5223	15	apelin	apelin	NN
cord-006229-7yoilsho	5223	16	isoforms	isoform	NNS
cord-006229-7yoilsho	5223	17	,	,	,
cord-006229-7yoilsho	5223	18	predominantly	predominantly	RB
cord-006229-7yoilsho	5223	19	apelin-17	apelin-17	NN
cord-006229-7yoilsho	5223	20	.	.	.
cord-006229-7yoilsho	5224	1	Upon	upon	IN
cord-006229-7yoilsho	5224	2	platelet	platelet	NN
cord-006229-7yoilsho	5224	3	activation	activation	NN
cord-006229-7yoilsho	5224	4	,	,	,
cord-006229-7yoilsho	5224	5	APJ	APJ	NNP
cord-006229-7yoilsho	5224	6	is	be	VBZ
cord-006229-7yoilsho	5224	7	internalized	internalize	VBN
cord-006229-7yoilsho	5224	8	and	and	CC
cord-006229-7yoilsho	5224	9	surface	surface	NN
cord-006229-7yoilsho	5224	10	expression	expression	NN
cord-006229-7yoilsho	5224	11	is	be	VBZ
cord-006229-7yoilsho	5224	12	reduced	reduce	VBN
cord-006229-7yoilsho	5224	13	by	by	IN
cord-006229-7yoilsho	5224	14	about	about	RB
cord-006229-7yoilsho	5224	15	50	50	CD
cord-006229-7yoilsho	5224	16	%	%	NN
cord-006229-7yoilsho	5224	17	.	.	.
cord-006229-7yoilsho	5225	1	In	in	IN
cord-006229-7yoilsho	5225	2	MI	MI	NNP
cord-006229-7yoilsho	5225	3	patients	patient	NNS
cord-006229-7yoilsho	5225	4	,	,	,
cord-006229-7yoilsho	5225	5	plasma	plasma	NN
cord-006229-7yoilsho	5225	6	levels	level	NNS
cord-006229-7yoilsho	5225	7	of	of	IN
cord-006229-7yoilsho	5225	8	apelin-17	apelin-17	NN
cord-006229-7yoilsho	5225	9	and	and	CC
cord-006229-7yoilsho	5225	10	platelet	platelet	NN
cord-006229-7yoilsho	5225	11	APJ	APJ	NNP
cord-006229-7yoilsho	5225	12	expression	expression	NN
cord-006229-7yoilsho	5225	13	were	be	VBD
cord-006229-7yoilsho	5225	14	reduced	reduce	VBN
cord-006229-7yoilsho	5225	15	.	.	.
cord-006229-7yoilsho	5226	1	This	this	DT
cord-006229-7yoilsho	5226	2	correlated	correlate	VBD
cord-006229-7yoilsho	5226	3	inversely	inversely	RB
cord-006229-7yoilsho	5226	4	with	with	IN
cord-006229-7yoilsho	5226	5	troponin	troponin	JJ
cord-006229-7yoilsho	5226	6	T	t	NN
cord-006229-7yoilsho	5226	7	levels	level	NNS
cord-006229-7yoilsho	5226	8	.	.	.
cord-006229-7yoilsho	5227	1	Reduced	reduce	VBN
cord-006229-7yoilsho	5227	2	circulating	circulate	VBG
cord-006229-7yoilsho	5227	3	apelin-17	apelin-17	NN
cord-006229-7yoilsho	5227	4	levels	level	NNS
cord-006229-7yoilsho	5227	5	and	and	CC
cord-006229-7yoilsho	5227	6	platelet	platelet	NN
cord-006229-7yoilsho	5227	7	APJ	APJ	NNP
cord-006229-7yoilsho	5227	8	expression	expression	NN
cord-006229-7yoilsho	5227	9	may	may	MD
cord-006229-7yoilsho	5227	10	be	be	VB
cord-006229-7yoilsho	5227	11	associated	associate	VBN
cord-006229-7yoilsho	5227	12	or	or	CC
cord-006229-7yoilsho	5227	13	partly	partly	RB
cord-006229-7yoilsho	5227	14	account	account	VBP
cord-006229-7yoilsho	5227	15	for	for	IN
cord-006229-7yoilsho	5227	16	platelet	platelet	NN
cord-006229-7yoilsho	5227	17	hyperactivity	hyperactivity	NN
cord-006229-7yoilsho	5227	18	in	in	IN
cord-006229-7yoilsho	5227	19	MI	MI	NNP
cord-006229-7yoilsho	5227	20	patients	patient	NNS
cord-006229-7yoilsho	5227	21	.	.	.
cord-006229-7yoilsho	5228	1	Anticholinergic	Anticholinergic	NNP
cord-006229-7yoilsho	5228	2	drug	drug	NN
cord-006229-7yoilsho	5228	3	use	use	NN
cord-006229-7yoilsho	5228	4	,	,	,
cord-006229-7yoilsho	5228	5	M	M	NNP
cord-006229-7yoilsho	5228	6	1	1	CD
cord-006229-7yoilsho	5228	7	receptor	receptor	NN
cord-006229-7yoilsho	5228	8	affinity	affinity	NN
cord-006229-7yoilsho	5228	9	and	and	CC
cord-006229-7yoilsho	5228	10	dementia	dementia	NN
cord-006229-7yoilsho	5228	11	risk	risk	NN
cord-006229-7yoilsho	5228	12	-	-	:
cord-006229-7yoilsho	5228	13	a	a	DT
cord-006229-7yoilsho	5228	14	pharmacoepidemiological	pharmacoepidemiological	JJ
cord-006229-7yoilsho	5228	15	analysis	analysis	NN
cord-006229-7yoilsho	5228	16	using	use	VBG
cord-006229-7yoilsho	5228	17	claims	claim	NNS
cord-006229-7yoilsho	5228	18	data	datum	NNS
cord-006229-7yoilsho	5228	19	F.	F.	NNP
cord-006229-7yoilsho	5228	20	Thome	Thome	NNP
cord-006229-7yoilsho	5228	21	Background	Background	NNP
cord-006229-7yoilsho	5228	22	:	:	:
cord-006229-7yoilsho	5228	23	Dementia	Dementia	NNP
cord-006229-7yoilsho	5228	24	is	be	VBZ
cord-006229-7yoilsho	5228	25	characterized	characterize	VBN
cord-006229-7yoilsho	5228	26	by	by	IN
cord-006229-7yoilsho	5228	27	cumulative	cumulative	JJ
cord-006229-7yoilsho	5228	28	cognitive	cognitive	JJ
cord-006229-7yoilsho	5228	29	decline	decline	NN
cord-006229-7yoilsho	5228	30	and	and	CC
cord-006229-7yoilsho	5228	31	progressive	progressive	JJ
cord-006229-7yoilsho	5228	32	inability	inability	NN
cord-006229-7yoilsho	5228	33	for	for	IN
cord-006229-7yoilsho	5228	34	independent	independent	JJ
cord-006229-7yoilsho	5228	35	living	living	NN
cord-006229-7yoilsho	5228	36	.	.	.
cord-006229-7yoilsho	5229	1	The	the	DT
cord-006229-7yoilsho	5229	2	lack	lack	NN
cord-006229-7yoilsho	5229	3	of	of	IN
cord-006229-7yoilsho	5229	4	suitable	suitable	JJ
cord-006229-7yoilsho	5229	5	therapies	therapy	NNS
cord-006229-7yoilsho	5229	6	for	for	IN
cord-006229-7yoilsho	5229	7	terminating	terminate	VBG
cord-006229-7yoilsho	5229	8	the	the	DT
cord-006229-7yoilsho	5229	9	progression	progression	NN
cord-006229-7yoilsho	5229	10	of	of	IN
cord-006229-7yoilsho	5229	11	this	this	DT
cord-006229-7yoilsho	5229	12	disease	disease	NN
cord-006229-7yoilsho	5229	13	underlines	underline	VBZ
cord-006229-7yoilsho	5229	14	the	the	DT
cord-006229-7yoilsho	5229	15	importance	importance	NN
cord-006229-7yoilsho	5229	16	of	of	IN
cord-006229-7yoilsho	5229	17	the	the	DT
cord-006229-7yoilsho	5229	18	detection	detection	NN
cord-006229-7yoilsho	5229	19	of	of	IN
cord-006229-7yoilsho	5229	20	risk	risk	NN
cord-006229-7yoilsho	5229	21	factors	factor	NNS
cord-006229-7yoilsho	5229	22	.	.	.
cord-006229-7yoilsho	5230	1	Anticholinergic	anticholinergic	NN
cord-006229-7yoilsho	5230	2	drugs	drug	NNS
cord-006229-7yoilsho	5230	3	have	have	VBP
cord-006229-7yoilsho	5230	4	been	be	VBN
cord-006229-7yoilsho	5230	5	shown	show	VBN
cord-006229-7yoilsho	5230	6	to	to	TO
cord-006229-7yoilsho	5230	7	enhance	enhance	VB
cord-006229-7yoilsho	5230	8	cognitive	cognitive	JJ
cord-006229-7yoilsho	5230	9	decline	decline	NN
cord-006229-7yoilsho	5230	10	in	in	IN
cord-006229-7yoilsho	5230	11	the	the	DT
cord-006229-7yoilsho	5230	12	elderly	elderly	JJ
cord-006229-7yoilsho	5230	13	.	.	.
cord-006229-7yoilsho	5231	1	The	the	DT
cord-006229-7yoilsho	5231	2	classification	classification	NN
cord-006229-7yoilsho	5231	3	of	of	IN
cord-006229-7yoilsho	5231	4	anticholinergic	anticholinergic	JJ
cord-006229-7yoilsho	5231	5	drugs	drug	NNS
cord-006229-7yoilsho	5231	6	according	accord	VBG
cord-006229-7yoilsho	5231	7	to	to	IN
cord-006229-7yoilsho	5231	8	their	-PRON-	PRP$
cord-006229-7yoilsho	5231	9	anticholinergic	anticholinergic	JJ
cord-006229-7yoilsho	5231	10	burden	burden	NN
cord-006229-7yoilsho	5231	11	,	,	,
cord-006229-7yoilsho	5231	12	however	however	RB
cord-006229-7yoilsho	5231	13	,	,	,
cord-006229-7yoilsho	5231	14	is	be	VBZ
cord-006229-7yoilsho	5231	15	inconsistent	inconsistent	JJ
cord-006229-7yoilsho	5231	16	.	.	.
cord-006229-7yoilsho	5232	1	Since	since	IN
cord-006229-7yoilsho	5232	2	cholinergic	cholinergic	JJ
cord-006229-7yoilsho	5232	3	transmission	transmission	NN
cord-006229-7yoilsho	5232	4	is	be	VBZ
cord-006229-7yoilsho	5232	5	mainly	mainly	RB
cord-006229-7yoilsho	5232	6	mediated	mediate	VBN
cord-006229-7yoilsho	5232	7	by	by	IN
cord-006229-7yoilsho	5232	8	the	the	DT
cord-006229-7yoilsho	5232	9	M	M	NNP
cord-006229-7yoilsho	5232	10	1	1	CD
cord-006229-7yoilsho	5232	11	muscarinic	muscarinic	JJ
cord-006229-7yoilsho	5232	12	acetylcholine	acetylcholine	NN
cord-006229-7yoilsho	5232	13	receptor	receptor	NN
cord-006229-7yoilsho	5232	14	in	in	IN
cord-006229-7yoilsho	5232	15	the	the	DT
cord-006229-7yoilsho	5232	16	brain	brain	NN
cord-006229-7yoilsho	5232	17	,	,	,
cord-006229-7yoilsho	5232	18	we	-PRON-	PRP
cord-006229-7yoilsho	5232	19	classified	classify	VBD
cord-006229-7yoilsho	5232	20	anticholinergic	anticholinergic	JJ
cord-006229-7yoilsho	5232	21	drugs	drug	NNS
cord-006229-7yoilsho	5232	22	from	from	IN
cord-006229-7yoilsho	5232	23	anticholinergic	anticholinergic	JJ
cord-006229-7yoilsho	5232	24	risk	risk	NN
cord-006229-7yoilsho	5232	25	lists	list	NNS
cord-006229-7yoilsho	5232	26	according	accord	VBG
cord-006229-7yoilsho	5232	27	to	to	IN
cord-006229-7yoilsho	5232	28	their	-PRON-	PRP$
cord-006229-7yoilsho	5232	29	affinity	affinity	NN
cord-006229-7yoilsho	5232	30	for	for	IN
cord-006229-7yoilsho	5232	31	the	the	DT
cord-006229-7yoilsho	5232	32	M	M	NNP
cord-006229-7yoilsho	5232	33	1	1	CD
cord-006229-7yoilsho	5232	34	receptor	receptor	NN
cord-006229-7yoilsho	5232	35	subtype	subtype	NN
cord-006229-7yoilsho	5232	36	and	and	CC
cord-006229-7yoilsho	5232	37	calculated	calculate	VBD
cord-006229-7yoilsho	5232	38	the	the	DT
cord-006229-7yoilsho	5232	39	risk	risk	NN
cord-006229-7yoilsho	5232	40	for	for	IN
cord-006229-7yoilsho	5232	41	the	the	DT
cord-006229-7yoilsho	5232	42	onset	onset	NN
cord-006229-7yoilsho	5232	43	of	of	IN
cord-006229-7yoilsho	5232	44	incident	incident	NN
cord-006229-7yoilsho	5232	45	dementia	dementia	NN
cord-006229-7yoilsho	5232	46	.	.	.
cord-006229-7yoilsho	5233	1	Methods	method	NNS
cord-006229-7yoilsho	5233	2	:	:	:
cord-006229-7yoilsho	5233	3	Our	-PRON-	PRP$
cord-006229-7yoilsho	5233	4	analyses	analysis	NNS
cord-006229-7yoilsho	5233	5	are	be	VBP
cord-006229-7yoilsho	5233	6	based	base	VBN
cord-006229-7yoilsho	5233	7	on	on	IN
cord-006229-7yoilsho	5233	8	claims	claim	NNS
cord-006229-7yoilsho	5233	9	data	datum	NNS
cord-006229-7yoilsho	5233	10	of	of	IN
cord-006229-7yoilsho	5233	11	the	the	DT
cord-006229-7yoilsho	5233	12	public	public	JJ
cord-006229-7yoilsho	5233	13	health	health	NN
cord-006229-7yoilsho	5233	14	insurance	insurance	NN
cord-006229-7yoilsho	5233	15	fund	fund	NN
cord-006229-7yoilsho	5233	16	AOK	AOK	NNP
cord-006229-7yoilsho	5233	17	.	.	.
cord-006229-7yoilsho	5234	1	Data	datum	NNS
cord-006229-7yoilsho	5234	2	include	include	VBP
cord-006229-7yoilsho	5234	3	information	information	NN
cord-006229-7yoilsho	5234	4	of	of	IN
cord-006229-7yoilsho	5234	5	inpatient	inpatient	JJ
cord-006229-7yoilsho	5234	6	and	and	CC
cord-006229-7yoilsho	5234	7	outpatient	outpatient	NN
cord-006229-7yoilsho	5234	8	diagnoses	diagnosis	NNS
cord-006229-7yoilsho	5234	9	and	and	CC
cord-006229-7yoilsho	5234	10	treatment	treatment	NN
cord-006229-7yoilsho	5234	11	from	from	IN
cord-006229-7yoilsho	5234	12	2004	2004	CD
cord-006229-7yoilsho	5234	13	to	to	IN
cord-006229-7yoilsho	5234	14	2011	2011	CD
cord-006229-7yoilsho	5234	15	.	.	.
cord-006229-7yoilsho	5235	1	Inclusion	inclusion	NN
cord-006229-7yoilsho	5235	2	criteria	criterion	NNS
cord-006229-7yoilsho	5235	3	comprised	comprise	VBD
cord-006229-7yoilsho	5235	4	the	the	DT
cord-006229-7yoilsho	5235	5	initial	initial	JJ
cord-006229-7yoilsho	5235	6	absence	absence	NN
cord-006229-7yoilsho	5235	7	of	of	IN
cord-006229-7yoilsho	5235	8	dementia	dementia	NN
cord-006229-7yoilsho	5235	9	and	and	CC
cord-006229-7yoilsho	5235	10	age	age	NN
cord-006229-7yoilsho	5235	11	of	of	IN
cord-006229-7yoilsho	5235	12	75	75	CD
cord-006229-7yoilsho	5235	13	years	year	NNS
cord-006229-7yoilsho	5235	14	or	or	CC
cord-006229-7yoilsho	5235	15	older	old	JJR
cord-006229-7yoilsho	5235	16	in	in	IN
cord-006229-7yoilsho	5235	17	2004	2004	CD
cord-006229-7yoilsho	5235	18	.	.	.
cord-006229-7yoilsho	5236	1	Anticholinergic	Anticholinergic	NNP
cord-006229-7yoilsho	5236	2	drugs	drug	NNS
cord-006229-7yoilsho	5236	3	were	be	VBD
cord-006229-7yoilsho	5236	4	taken	take	VBN
cord-006229-7yoilsho	5236	5	from	from	IN
cord-006229-7yoilsho	5236	6	three	three	CD
cord-006229-7yoilsho	5236	7	anticholinergic	anticholinergic	JJ
cord-006229-7yoilsho	5236	8	risk	risk	NN
cord-006229-7yoilsho	5236	9	lists	list	NNS
cord-006229-7yoilsho	5236	10	.	.	.
cord-006229-7yoilsho	5237	1	The	the	DT
cord-006229-7yoilsho	5237	2	PDSP	PDSP	NNP
cord-006229-7yoilsho	5237	3	-	-	HYPH
cord-006229-7yoilsho	5237	4	database	database	NN
cord-006229-7yoilsho	5237	5	and	and	CC
cord-006229-7yoilsho	5237	6	literature	literature	NN
cord-006229-7yoilsho	5237	7	search	search	NN
cord-006229-7yoilsho	5237	8	were	be	VBD
cord-006229-7yoilsho	5237	9	used	use	VBN
cord-006229-7yoilsho	5237	10	to	to	TO
cord-006229-7yoilsho	5237	11	define	define	VB
cord-006229-7yoilsho	5237	12	K	K	NNP
cord-006229-7yoilsho	5238	1	i	i	PRP
cord-006229-7yoilsho	5238	2	-values	-value	VBZ
cord-006229-7yoilsho	5238	3	for	for	IN
cord-006229-7yoilsho	5238	4	the	the	DT
cord-006229-7yoilsho	5238	5	substances	substance	NNS
cord-006229-7yoilsho	5238	6	.	.	.
cord-006229-7yoilsho	5239	1	Hazard	hazard	NN
cord-006229-7yoilsho	5239	2	ratios	ratio	NNS
cord-006229-7yoilsho	5239	3	were	be	VBD
cord-006229-7yoilsho	5239	4	calculated	calculate	VBN
cord-006229-7yoilsho	5239	5	using	use	VBG
cord-006229-7yoilsho	5239	6	time	time	NN
cord-006229-7yoilsho	5239	7	-	-	HYPH
cord-006229-7yoilsho	5239	8	dependent	dependent	JJ
cord-006229-7yoilsho	5239	9	Cox	Cox	NNP
cord-006229-7yoilsho	5239	10	regression	regression	NN
cord-006229-7yoilsho	5239	11	including	include	VBG
cord-006229-7yoilsho	5239	12	covariates	covariate	NNS
cord-006229-7yoilsho	5239	13	like	like	IN
cord-006229-7yoilsho	5239	14	age	age	NN
cord-006229-7yoilsho	5239	15	,	,	,
cord-006229-7yoilsho	5239	16	gender	gender	NN
cord-006229-7yoilsho	5239	17	,	,	,
cord-006229-7yoilsho	5239	18	and	and	CC
cord-006229-7yoilsho	5239	19	several	several	JJ
cord-006229-7yoilsho	5239	20	comorbidities	comorbiditie	NNS
cord-006229-7yoilsho	5239	21	.	.	.
cord-006229-7yoilsho	5240	1	Results	result	NNS
cord-006229-7yoilsho	5240	2	and	and	CC
cord-006229-7yoilsho	5240	3	Conclusion	conclusion	NN
cord-006229-7yoilsho	5240	4	:	:	:
cord-006229-7yoilsho	5240	5	Anticholinergic	Anticholinergic	NNP
cord-006229-7yoilsho	5240	6	drug	drug	NN
cord-006229-7yoilsho	5240	7	exposure	exposure	NN
cord-006229-7yoilsho	5240	8	increases	increase	VBZ
cord-006229-7yoilsho	5240	9	the	the	DT
cord-006229-7yoilsho	5240	10	risk	risk	NN
cord-006229-7yoilsho	5240	11	for	for	IN
cord-006229-7yoilsho	5240	12	dementia	dementia	NN
cord-006229-7yoilsho	5240	13	.	.	.
cord-006229-7yoilsho	5241	1	We	-PRON-	PRP
cord-006229-7yoilsho	5241	2	found	find	VBD
cord-006229-7yoilsho	5241	3	that	that	IN
cord-006229-7yoilsho	5241	4	anticholinergics	anticholinergic	NNS
cord-006229-7yoilsho	5241	5	with	with	IN
cord-006229-7yoilsho	5241	6	small	small	JJ
cord-006229-7yoilsho	5241	7	K	k	NN
cord-006229-7yoilsho	5242	1	i	i	PRP
cord-006229-7yoilsho	5242	2	-values	-value	VBZ
cord-006229-7yoilsho	5242	3	are	be	VBP
cord-006229-7yoilsho	5242	4	at	at	IN
cord-006229-7yoilsho	5242	5	a	a	DT
cord-006229-7yoilsho	5242	6	higher	high	JJR
cord-006229-7yoilsho	5242	7	risk	risk	NN
cord-006229-7yoilsho	5242	8	than	than	IN
cord-006229-7yoilsho	5242	9	those	those	DT
cord-006229-7yoilsho	5242	10	with	with	IN
cord-006229-7yoilsho	5242	11	greater	great	JJR
cord-006229-7yoilsho	5242	12	K	k	XX
cord-006229-7yoilsho	5243	1	i	i	PRP
cord-006229-7yoilsho	5243	2	-values	-value	VBZ
cord-006229-7yoilsho	5243	3	.	.	.
cord-006229-7yoilsho	5244	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	5244	2	,	,	,
cord-006229-7yoilsho	5244	3	conventional	conventional	JJ
cord-006229-7yoilsho	5244	4	risk	risk	NN
cord-006229-7yoilsho	5244	5	factors	factor	NNS
cord-006229-7yoilsho	5244	6	for	for	IN
cord-006229-7yoilsho	5244	7	dementia	dementia	NN
cord-006229-7yoilsho	5244	8	(	(	-LRB-
cord-006229-7yoilsho	5244	9	e.g.	e.g.	RB
cord-006229-7yoilsho	5244	10	age	age	NN
cord-006229-7yoilsho	5244	11	,	,	,
cord-006229-7yoilsho	5244	12	depression	depression	NN
cord-006229-7yoilsho	5244	13	,	,	,
cord-006229-7yoilsho	5244	14	stroke	stroke	NN
cord-006229-7yoilsho	5244	15	)	)	-RRB-
cord-006229-7yoilsho	5244	16	could	could	MD
cord-006229-7yoilsho	5244	17	be	be	VB
cord-006229-7yoilsho	5244	18	confirmed	confirm	VBN
cord-006229-7yoilsho	5244	19	.	.	.
cord-006229-7yoilsho	5245	1	In	in	IN
cord-006229-7yoilsho	5245	2	conclusion	conclusion	NN
cord-006229-7yoilsho	5245	3	,	,	,
cord-006229-7yoilsho	5245	4	the	the	DT
cord-006229-7yoilsho	5245	5	intake	intake	NN
cord-006229-7yoilsho	5245	6	of	of	IN
cord-006229-7yoilsho	5245	7	anticholinergic	anticholinergic	JJ
cord-006229-7yoilsho	5245	8	drugs	drug	NNS
cord-006229-7yoilsho	5245	9	increases	increase	VBZ
cord-006229-7yoilsho	5245	10	the	the	DT
cord-006229-7yoilsho	5245	11	risk	risk	NN
cord-006229-7yoilsho	5245	12	for	for	IN
cord-006229-7yoilsho	5245	13	incident	incident	NN
cord-006229-7yoilsho	5245	14	dementia	dementia	NN
cord-006229-7yoilsho	5245	15	in	in	IN
cord-006229-7yoilsho	5245	16	the	the	DT
cord-006229-7yoilsho	5245	17	elderly	elderly	JJ
cord-006229-7yoilsho	5245	18	.	.	.
cord-006229-7yoilsho	5246	1	Taking	take	VBG
cord-006229-7yoilsho	5246	2	into	into	IN
cord-006229-7yoilsho	5246	3	account	account	NN
cord-006229-7yoilsho	5246	4	the	the	DT
cord-006229-7yoilsho	5246	5	M	M	NNP
cord-006229-7yoilsho	5246	6	1	1	CD
cord-006229-7yoilsho	5246	7	receptor	receptor	NN
cord-006229-7yoilsho	5246	8	affinity	affinity	NN
cord-006229-7yoilsho	5246	9	may	may	MD
cord-006229-7yoilsho	5246	10	be	be	VB
cord-006229-7yoilsho	5246	11	a	a	DT
cord-006229-7yoilsho	5246	12	contribution	contribution	NN
cord-006229-7yoilsho	5246	13	in	in	IN
cord-006229-7yoilsho	5246	14	determining	determine	VBG
cord-006229-7yoilsho	5246	15	the	the	DT
cord-006229-7yoilsho	5246	16	anticholinergic	anticholinergic	JJ
cord-006229-7yoilsho	5246	17	load	load	NN
cord-006229-7yoilsho	5246	18	in	in	IN
cord-006229-7yoilsho	5246	19	view	view	NN
cord-006229-7yoilsho	5246	20	of	of	IN
cord-006229-7yoilsho	5246	21	the	the	DT
cord-006229-7yoilsho	5246	22	risk	risk	NN
cord-006229-7yoilsho	5246	23	for	for	IN
cord-006229-7yoilsho	5246	24	incident	incident	NN
cord-006229-7yoilsho	5246	25	dementia	dementia	NN
cord-006229-7yoilsho	5246	26	.	.	.
cord-006229-7yoilsho	5247	1	Safety	safety	NN
cord-006229-7yoilsho	5247	2	signal	signal	NN
cord-006229-7yoilsho	5247	3	detection	detection	NN
cord-006229-7yoilsho	5247	4	in	in	IN
cord-006229-7yoilsho	5247	5	a	a	DT
cord-006229-7yoilsho	5247	6	large	large	JJ
cord-006229-7yoilsho	5247	7	german	german	JJ
cord-006229-7yoilsho	5247	8	statutory	statutory	JJ
cord-006229-7yoilsho	5247	9	health	health	NN
cord-006229-7yoilsho	5247	10	insurance	insurance	NN
cord-006229-7yoilsho	5247	11	databasefirst	databasefirst	NN
cord-006229-7yoilsho	5247	12	results	result	NNS
cord-006229-7yoilsho	5247	13	of	of	IN
cord-006229-7yoilsho	5247	14	a	a	DT
cord-006229-7yoilsho	5247	15	feasibility	feasibility	NN
cord-006229-7yoilsho	5247	16	assessment	assessment	NN
cord-006229-7yoilsho	5247	17	F.	F.	NNP
cord-006229-7yoilsho	5247	18	Andersohn	Andersohn	NNP
cord-006229-7yoilsho	5247	19	1,2	1,2	CD
cord-006229-7yoilsho	5247	20	,	,	,
cord-006229-7yoilsho	5247	21	S.	S.	NNP
cord-006229-7yoilsho	5247	22	Schmiedl	Schmiedl	NNP
cord-006229-7yoilsho	5247	23	3	3	CD
cord-006229-7yoilsho	5247	24	,	,	,
cord-006229-7yoilsho	5247	25	4	4	CD
cord-006229-7yoilsho	5247	26	,	,	,
cord-006229-7yoilsho	5247	27	K.	K.	NNP
cord-006229-7yoilsho	5247	28	Janhsen	Janhsen	NNP
cord-006229-7yoilsho	5247	29	3	3	CD
cord-006229-7yoilsho	5247	30	,	,	,
cord-006229-7yoilsho	5247	31	5	5	CD
cord-006229-7yoilsho	5247	32	,	,	,
cord-006229-7yoilsho	5247	33	P.	P.	NNP
cord-006229-7yoilsho	5247	34	Thuermann	Thuermann	NNP
cord-006229-7yoilsho	5247	35	3	3	CD
cord-006229-7yoilsho	5247	36	,	,	,
cord-006229-7yoilsho	5247	37	4	4	CD
cord-006229-7yoilsho	5247	38	,	,	,
cord-006229-7yoilsho	5247	39	J.	J.	NNP
cord-006229-7yoilsho	5247	40	Walker	Walker	NNP
cord-006229-7yoilsho	5247	41	Background	Background	NNP
cord-006229-7yoilsho	5248	1	:	:	:
cord-006229-7yoilsho	5248	2	During	during	IN
cord-006229-7yoilsho	5248	3	the	the	DT
cord-006229-7yoilsho	5248	4	last	last	JJ
cord-006229-7yoilsho	5248	5	years	year	NNS
cord-006229-7yoilsho	5248	6	,	,	,
cord-006229-7yoilsho	5248	7	approaches	approach	VBZ
cord-006229-7yoilsho	5248	8	to	to	TO
cord-006229-7yoilsho	5248	9	routinely	routinely	RB
cord-006229-7yoilsho	5248	10	screen	screen	VB
cord-006229-7yoilsho	5248	11	health	health	NN
cord-006229-7yoilsho	5248	12	care	care	NN
cord-006229-7yoilsho	5248	13	databases	database	NNS
cord-006229-7yoilsho	5248	14	based	base	VBN
cord-006229-7yoilsho	5248	15	on	on	IN
cord-006229-7yoilsho	5248	16	electronic	electronic	JJ
cord-006229-7yoilsho	5248	17	medical	medical	JJ
cord-006229-7yoilsho	5248	18	records	record	NNS
cord-006229-7yoilsho	5248	19	or	or	CC
cord-006229-7yoilsho	5248	20	claims	claim	VBZ
cord-006229-7yoilsho	5248	21	to	to	TO
cord-006229-7yoilsho	5248	22	identify	identify	VB
cord-006229-7yoilsho	5248	23	drug	drug	NN
cord-006229-7yoilsho	5248	24	safety	safety	NN
cord-006229-7yoilsho	5248	25	signals	signal	NNS
cord-006229-7yoilsho	5248	26	were	be	VBD
cord-006229-7yoilsho	5248	27	proposed	propose	VBN
cord-006229-7yoilsho	5248	28	.	.	.
cord-006229-7yoilsho	5249	1	To	to	TO
cord-006229-7yoilsho	5249	2	evaluate	evaluate	VB
cord-006229-7yoilsho	5249	3	the	the	DT
cord-006229-7yoilsho	5249	4	performance	performance	NN
cord-006229-7yoilsho	5249	5	of	of	IN
cord-006229-7yoilsho	5249	6	such	such	JJ
cord-006229-7yoilsho	5249	7	methods	method	NNS
cord-006229-7yoilsho	5249	8	,	,	,
cord-006229-7yoilsho	5249	9	reference	reference	NN
cord-006229-7yoilsho	5249	10	sets	set	NNS
cord-006229-7yoilsho	5249	11	of	of	IN
cord-006229-7yoilsho	5249	12	index	index	NN
cord-006229-7yoilsho	5249	13	drugs	drug	NNS
cord-006229-7yoilsho	5249	14	have	have	VBP
cord-006229-7yoilsho	5249	15	been	be	VBN
cord-006229-7yoilsho	5249	16	compiled	compile	VBN
cord-006229-7yoilsho	5249	17	consisting	consist	VBG
cord-006229-7yoilsho	5249	18	of	of	IN
cord-006229-7yoilsho	5249	19	(	(	-LRB-
cord-006229-7yoilsho	5249	20	1	1	CD
cord-006229-7yoilsho	5249	21	)	)	-RRB-
cord-006229-7yoilsho	5249	22	drugs	drug	NNS
cord-006229-7yoilsho	5249	23	with	with	IN
cord-006229-7yoilsho	5249	24	a	a	DT
cord-006229-7yoilsho	5249	25	known	know	VBN
cord-006229-7yoilsho	5249	26	association	association	NN
cord-006229-7yoilsho	5249	27	to	to	IN
cord-006229-7yoilsho	5249	28	a	a	DT
cord-006229-7yoilsho	5249	29	certain	certain	JJ
cord-006229-7yoilsho	5249	30	adverse	adverse	JJ
cord-006229-7yoilsho	5249	31	event	event	NN
cord-006229-7yoilsho	5249	32	(	(	-LRB-
cord-006229-7yoilsho	5249	33	=	=	NFP
cord-006229-7yoilsho	5249	34	positive	positive	JJ
cord-006229-7yoilsho	5249	35	controls	control	NNS
cord-006229-7yoilsho	5249	36	)	)	-RRB-
cord-006229-7yoilsho	5249	37	and	and	CC
cord-006229-7yoilsho	5249	38	(	(	-LRB-
cord-006229-7yoilsho	5249	39	2	2	LS
cord-006229-7yoilsho	5249	40	)	)	-RRB-
cord-006229-7yoilsho	5249	41	drugs	drug	NNS
cord-006229-7yoilsho	5249	42	without	without	IN
cord-006229-7yoilsho	5249	43	any	any	DT
cord-006229-7yoilsho	5249	44	evidence	evidence	NN
cord-006229-7yoilsho	5249	45	to	to	TO
cord-006229-7yoilsho	5249	46	cause	cause	VB
cord-006229-7yoilsho	5249	47	this	this	DT
cord-006229-7yoilsho	5249	48	adverse	adverse	JJ
cord-006229-7yoilsho	5249	49	event	event	NN
cord-006229-7yoilsho	5249	50	(	(	-LRB-
cord-006229-7yoilsho	5249	51	=	=	SYM
cord-006229-7yoilsho	5249	52	negative	negative	JJ
cord-006229-7yoilsho	5249	53	controls	control	NNS
cord-006229-7yoilsho	5249	54	)	)	-RRB-
cord-006229-7yoilsho	5249	55	.	.	.
cord-006229-7yoilsho	5250	1	The	the	DT
cord-006229-7yoilsho	5250	2	best	well	RBS
cord-006229-7yoilsho	5250	3	possible	possible	JJ
cord-006229-7yoilsho	5250	4	signal	signal	NN
cord-006229-7yoilsho	5250	5	detection	detection	NN
cord-006229-7yoilsho	5250	6	method	method	NN
cord-006229-7yoilsho	5250	7	would	would	MD
cord-006229-7yoilsho	5250	8	identify	identify	VB
cord-006229-7yoilsho	5250	9	a	a	DT
cord-006229-7yoilsho	5250	10	safety	safety	NN
cord-006229-7yoilsho	5250	11	signal	signal	NN
cord-006229-7yoilsho	5250	12	for	for	IN
cord-006229-7yoilsho	5250	13	100	100	CD
cord-006229-7yoilsho	5250	14	%	%	NN
cord-006229-7yoilsho	5250	15	of	of	IN
cord-006229-7yoilsho	5250	16	the	the	DT
cord-006229-7yoilsho	5250	17	positive	positive	JJ
cord-006229-7yoilsho	5250	18	control	control	NN
cord-006229-7yoilsho	5250	19	drugs	drug	NNS
cord-006229-7yoilsho	5250	20	,	,	,
cord-006229-7yoilsho	5250	21	and	and	CC
cord-006229-7yoilsho	5250	22	for	for	IN
cord-006229-7yoilsho	5250	23	none	none	NN
cord-006229-7yoilsho	5250	24	of	of	IN
cord-006229-7yoilsho	5250	25	the	the	DT
cord-006229-7yoilsho	5250	26	negative	negative	JJ
cord-006229-7yoilsho	5250	27	controls	control	NNS
cord-006229-7yoilsho	5250	28	.	.	.
cord-006229-7yoilsho	5251	1	Ryan	Ryan	NNP
cord-006229-7yoilsho	5251	2	et	et	NNP
cord-006229-7yoilsho	5251	3	al	al	NNP
cord-006229-7yoilsho	5251	4	.	.	.
cord-006229-7yoilsho	5252	1	2013	2013	CD
cord-006229-7yoilsho	5252	2	developed	develop	VBN
cord-006229-7yoilsho	5252	3	drug	drug	NN
cord-006229-7yoilsho	5252	4	reference	reference	NN
cord-006229-7yoilsho	5252	5	sets	set	NNS
cord-006229-7yoilsho	5252	6	for	for	IN
cord-006229-7yoilsho	5252	7	four	four	CD
cord-006229-7yoilsho	5252	8	adverse	adverse	JJ
cord-006229-7yoilsho	5252	9	events	event	NNS
cord-006229-7yoilsho	5252	10	of	of	IN
cord-006229-7yoilsho	5252	11	interest	interest	NN
cord-006229-7yoilsho	5252	12	(	(	-LRB-
cord-006229-7yoilsho	5252	13	acute	acute	JJ
cord-006229-7yoilsho	5252	14	myocardial	myocardial	JJ
cord-006229-7yoilsho	5252	15	infarction	infarction	NN
cord-006229-7yoilsho	5252	16	=	=	NFP
cord-006229-7yoilsho	5252	17	AMI	AMI	NNP
cord-006229-7yoilsho	5252	18	,	,	,
cord-006229-7yoilsho	5252	19	acute	acute	JJ
cord-006229-7yoilsho	5252	20	kidney	kidney	NN
cord-006229-7yoilsho	5252	21	injury	injury	NN
cord-006229-7yoilsho	5252	22	=	=	SYM
cord-006229-7yoilsho	5252	23	AKI	AKI	NNP
cord-006229-7yoilsho	5252	24	,	,	,
cord-006229-7yoilsho	5252	25	acute	acute	JJ
cord-006229-7yoilsho	5252	26	liver	liver	NN
cord-006229-7yoilsho	5252	27	injury	injury	NN
cord-006229-7yoilsho	5252	28	=	=	NFP
cord-006229-7yoilsho	5252	29	ALI	ALI	NNP
cord-006229-7yoilsho	5252	30	,	,	,
cord-006229-7yoilsho	5252	31	and	and	CC
cord-006229-7yoilsho	5252	32	upper	upper	JJ
cord-006229-7yoilsho	5252	33	gastrointestinal	gastrointestinal	JJ
cord-006229-7yoilsho	5252	34	bleeding	bleeding	NN
cord-006229-7yoilsho	5252	35	=	=	:
cord-006229-7yoilsho	5252	36	UGIB	UGIB	NNS
cord-006229-7yoilsho	5252	37	)	)	-RRB-
cord-006229-7yoilsho	5252	38	and	and	CC
cord-006229-7yoilsho	5252	39	have	have	VBP
cord-006229-7yoilsho	5252	40	shown	show	VBN
cord-006229-7yoilsho	5252	41	feasibility	feasibility	NN
cord-006229-7yoilsho	5252	42	of	of	IN
cord-006229-7yoilsho	5252	43	using	use	VBG
cord-006229-7yoilsho	5252	44	these	these	DT
cord-006229-7yoilsho	5252	45	reference	reference	NN
cord-006229-7yoilsho	5252	46	sets	set	NNS
cord-006229-7yoilsho	5252	47	in	in	IN
cord-006229-7yoilsho	5252	48	US	US	NNP
cord-006229-7yoilsho	5252	49	health	health	NN
cord-006229-7yoilsho	5252	50	care	care	NN
cord-006229-7yoilsho	5252	51	databases	database	NNS
cord-006229-7yoilsho	5252	52	.	.	.
cord-006229-7yoilsho	5253	1	If	if	IN
cord-006229-7yoilsho	5253	2	the	the	DT
cord-006229-7yoilsho	5253	3	use	use	NN
cord-006229-7yoilsho	5253	4	of	of	IN
cord-006229-7yoilsho	5253	5	these	these	DT
cord-006229-7yoilsho	5253	6	US	US	NNP
cord-006229-7yoilsho	5253	7	specific	specific	JJ
cord-006229-7yoilsho	5253	8	drug	drug	NN
cord-006229-7yoilsho	5253	9	lists	list	NNS
cord-006229-7yoilsho	5253	10	for	for	IN
cord-006229-7yoilsho	5253	11	evaluation	evaluation	NN
cord-006229-7yoilsho	5253	12	of	of	IN
cord-006229-7yoilsho	5253	13	signal	signal	NN
cord-006229-7yoilsho	5253	14	detection	detection	NN
cord-006229-7yoilsho	5253	15	methods	method	NNS
cord-006229-7yoilsho	5253	16	is	be	VBZ
cord-006229-7yoilsho	5253	17	also	also	RB
cord-006229-7yoilsho	5253	18	feasible	feasible	JJ
cord-006229-7yoilsho	5253	19	within	within	IN
cord-006229-7yoilsho	5253	20	German	german	JJ
cord-006229-7yoilsho	5253	21	health	health	NN
cord-006229-7yoilsho	5253	22	care	care	NN
cord-006229-7yoilsho	5253	23	databases	database	NNS
cord-006229-7yoilsho	5253	24	,	,	,
cord-006229-7yoilsho	5253	25	is	be	VBZ
cord-006229-7yoilsho	5253	26	unknown	unknown	JJ
cord-006229-7yoilsho	5253	27	.	.	.
cord-006229-7yoilsho	5254	1	Aims	aim	VBZ
cord-006229-7yoilsho	5254	2	:	:	:
cord-006229-7yoilsho	5254	3	To	to	TO
cord-006229-7yoilsho	5254	4	evaluate	evaluate	VB
cord-006229-7yoilsho	5254	5	if	if	IN
cord-006229-7yoilsho	5254	6	the	the	DT
cord-006229-7yoilsho	5254	7	drug	drug	NN
cord-006229-7yoilsho	5254	8	reference	reference	NN
cord-006229-7yoilsho	5254	9	sets	set	NNS
cord-006229-7yoilsho	5254	10	developed	develop	VBN
cord-006229-7yoilsho	5254	11	by	by	IN
cord-006229-7yoilsho	5254	12	Ryan	Ryan	NNP
cord-006229-7yoilsho	5254	13	et	et	NNP
cord-006229-7yoilsho	5254	14	al	al	NNP
cord-006229-7yoilsho	5254	15	.	.	.
cord-006229-7yoilsho	5255	1	(	(	-LRB-
cord-006229-7yoilsho	5255	2	Drug	Drug	NNP
cord-006229-7yoilsho	5255	3	Saf	Saf	NNP
cord-006229-7yoilsho	5255	4	.	.	NNP
cord-006229-7yoilsho	5255	5	2013	2013	CD
cord-006229-7yoilsho	5255	6	;	;	:
cord-006229-7yoilsho	5255	7	36	36	CD
cord-006229-7yoilsho	5255	8	Suppl	Suppl	NNP
cord-006229-7yoilsho	5255	9	1	1	CD
cord-006229-7yoilsho	5255	10	:	:	:
cord-006229-7yoilsho	5255	11	S33	S33	NNP
cord-006229-7yoilsho	5255	12	-	-	HYPH
cord-006229-7yoilsho	5255	13	47	47	CD
cord-006229-7yoilsho	5255	14	)	)	-RRB-
cord-006229-7yoilsho	5255	15	could	could	MD
cord-006229-7yoilsho	5255	16	be	be	VB
cord-006229-7yoilsho	5255	17	used	use	VBN
cord-006229-7yoilsho	5255	18	for	for	IN
cord-006229-7yoilsho	5255	19	testing	test	VBG
cord-006229-7yoilsho	5255	20	signal	signal	NN
cord-006229-7yoilsho	5255	21	detection	detection	NN
cord-006229-7yoilsho	5255	22	methods	method	NNS
cord-006229-7yoilsho	5255	23	in	in	IN
cord-006229-7yoilsho	5255	24	a	a	DT
cord-006229-7yoilsho	5255	25	large	large	JJ
cord-006229-7yoilsho	5255	26	German	german	JJ
cord-006229-7yoilsho	5255	27	statutory	statutory	JJ
cord-006229-7yoilsho	5255	28	health	health	NN
cord-006229-7yoilsho	5255	29	insurance	insurance	NN
cord-006229-7yoilsho	5255	30	database	database	NN
cord-006229-7yoilsho	5255	31	.	.	.
cord-006229-7yoilsho	5256	1	Methods	method	NNS
cord-006229-7yoilsho	5256	2	:	:	:
cord-006229-7yoilsho	5257	1	Data	datum	NNS
cord-006229-7yoilsho	5257	2	source	source	NN
cord-006229-7yoilsho	5257	3	was	be	VBD
cord-006229-7yoilsho	5257	4	the	the	DT
cord-006229-7yoilsho	5257	5	Health	Health	NNP
cord-006229-7yoilsho	5257	6	Risk	Risk	NNP
cord-006229-7yoilsho	5257	7	Institute	Institute	NNP
cord-006229-7yoilsho	5257	8	(	(	-LRB-
cord-006229-7yoilsho	5257	9	HRI	HRI	NNP
cord-006229-7yoilsho	5257	10	)	)	-RRB-
cord-006229-7yoilsho	5257	11	database	database	NN
cord-006229-7yoilsho	5257	12	,	,	,
cord-006229-7yoilsho	5257	13	an	an	DT
cord-006229-7yoilsho	5257	14	anonymized	anonymized	JJ
cord-006229-7yoilsho	5257	15	healthcare	healthcare	NN
cord-006229-7yoilsho	5257	16	database	database	NN
cord-006229-7yoilsho	5257	17	with	with	IN
cord-006229-7yoilsho	5257	18	longitudinal	longitudinal	JJ
cord-006229-7yoilsho	5257	19	health	health	NN
cord-006229-7yoilsho	5257	20	insurance	insurance	NN
cord-006229-7yoilsho	5257	21	data	datum	NNS
cord-006229-7yoilsho	5257	22	from	from	IN
cord-006229-7yoilsho	5257	23	approximately	approximately	RB
cord-006229-7yoilsho	5257	24	six	six	CD
cord-006229-7yoilsho	5257	25	million	million	CD
cord-006229-7yoilsho	5257	26	Germans	Germans	NNPS
cord-006229-7yoilsho	5257	27	.	.	.
cord-006229-7yoilsho	5258	1	New	new	JJ
cord-006229-7yoilsho	5258	2	users	user	NNS
cord-006229-7yoilsho	5258	3	(	(	-LRB-
cord-006229-7yoilsho	5258	4	initiators	initiator	NNS
cord-006229-7yoilsho	5258	5	)	)	-RRB-
cord-006229-7yoilsho	5258	6	of	of	IN
cord-006229-7yoilsho	5258	7	index	index	NN
cord-006229-7yoilsho	5258	8	drugs	drug	NNS
cord-006229-7yoilsho	5258	9	in	in	IN
cord-006229-7yoilsho	5258	10	2010	2010	CD
cord-006229-7yoilsho	5258	11	to	to	IN
cord-006229-7yoilsho	5258	12	2013	2013	CD
cord-006229-7yoilsho	5258	13	were	be	VBD
cord-006229-7yoilsho	5258	14	identified	identify	VBN
cord-006229-7yoilsho	5258	15	and	and	CC
cord-006229-7yoilsho	5258	16	followed	follow	VBN
cord-006229-7yoilsho	5258	17	-	-	HYPH
cord-006229-7yoilsho	5258	18	up	up	NN
cord-006229-7yoilsho	5258	19	for	for	IN
cord-006229-7yoilsho	5258	20	one	one	CD
cord-006229-7yoilsho	5258	21	year	year	NN
cord-006229-7yoilsho	5258	22	from	from	IN
cord-006229-7yoilsho	5258	23	their	-PRON-	PRP$
cord-006229-7yoilsho	5258	24	first	first	JJ
cord-006229-7yoilsho	5258	25	prescription	prescription	NN
cord-006229-7yoilsho	5258	26	.	.	.
cord-006229-7yoilsho	5259	1	Exposed	expose	VBN
cord-006229-7yoilsho	5259	2	person	person	NN
cord-006229-7yoilsho	5259	3	-	-	HYPH
cord-006229-7yoilsho	5259	4	time	time	NN
cord-006229-7yoilsho	5259	5	to	to	IN
cord-006229-7yoilsho	5259	6	the	the	DT
cord-006229-7yoilsho	5259	7	respective	respective	JJ
cord-006229-7yoilsho	5259	8	index	index	NN
cord-006229-7yoilsho	5259	9	drug	drug	NN
cord-006229-7yoilsho	5259	10	was	be	VBD
cord-006229-7yoilsho	5259	11	assessed	assess	VBN
cord-006229-7yoilsho	5259	12	to	to	TO
cord-006229-7yoilsho	5259	13	estimate	estimate	VB
cord-006229-7yoilsho	5259	14	for	for	IN
cord-006229-7yoilsho	5259	15	which	which	WDT
cord-006229-7yoilsho	5259	16	of	of	IN
cord-006229-7yoilsho	5259	17	these	these	DT
cord-006229-7yoilsho	5259	18	drugs	drug	NNS
cord-006229-7yoilsho	5259	19	an	an	DT
cord-006229-7yoilsho	5259	20	increase	increase	NN
cord-006229-7yoilsho	5259	21	in	in	IN
cord-006229-7yoilsho	5259	22	risk	risk	NN
cord-006229-7yoilsho	5259	23	of	of	IN
cord-006229-7yoilsho	5259	24	50	50	CD
cord-006229-7yoilsho	5259	25	%	%	NN
cord-006229-7yoilsho	5259	26	(	(	-LRB-
cord-006229-7yoilsho	5259	27	relative	relative	JJ
cord-006229-7yoilsho	5259	28	risk	risk	NN
cord-006229-7yoilsho	5259	29	1.5	1.5	CD
cord-006229-7yoilsho	5259	30	)	)	-RRB-
cord-006229-7yoilsho	5259	31	compared	compare	VBN
cord-006229-7yoilsho	5259	32	to	to	IN
cord-006229-7yoilsho	5259	33	the	the	DT
cord-006229-7yoilsho	5259	34	background	background	NN
cord-006229-7yoilsho	5259	35	incidence	incidence	NN
cord-006229-7yoilsho	5259	36	of	of	IN
cord-006229-7yoilsho	5259	37	the	the	DT
cord-006229-7yoilsho	5259	38	respective	respective	JJ
cord-006229-7yoilsho	5259	39	adverse	adverse	JJ
cord-006229-7yoilsho	5259	40	event	event	NN
cord-006229-7yoilsho	5259	41	(	(	-LRB-
cord-006229-7yoilsho	5259	42	AMI	AMI	NNP
cord-006229-7yoilsho	5259	43	,	,	,
cord-006229-7yoilsho	5259	44	AKI	AKI	NNP
cord-006229-7yoilsho	5259	45	,	,	,
cord-006229-7yoilsho	5259	46	ALI	ALI	NNP
cord-006229-7yoilsho	5259	47	or	or	CC
cord-006229-7yoilsho	5259	48	UGIB	UGIB	NNP
cord-006229-7yoilsho	5259	49	)	)	-RRB-
cord-006229-7yoilsho	5259	50	could	could	MD
cord-006229-7yoilsho	5259	51	be	be	VB
cord-006229-7yoilsho	5259	52	identified	identify	VBN
cord-006229-7yoilsho	5259	53	with	with	IN
cord-006229-7yoilsho	5259	54	80	80	CD
cord-006229-7yoilsho	5259	55	%	%	NN
cord-006229-7yoilsho	5259	56	statistical	statistical	JJ
cord-006229-7yoilsho	5259	57	power	power	NN
cord-006229-7yoilsho	5259	58	.	.	.
cord-006229-7yoilsho	5260	1	Results	result	NNS
cord-006229-7yoilsho	5260	2	:	:	:
cord-006229-7yoilsho	5261	1	From	from	IN
cord-006229-7yoilsho	5261	2	a	a	DT
cord-006229-7yoilsho	5261	3	total	total	NN
cord-006229-7yoilsho	5261	4	of	of	IN
cord-006229-7yoilsho	5261	5	182	182	CD
cord-006229-7yoilsho	5261	6	index	index	NN
cord-006229-7yoilsho	5261	7	drugs	drug	NNS
cord-006229-7yoilsho	5261	8	in	in	IN
cord-006229-7yoilsho	5261	9	the	the	DT
cord-006229-7yoilsho	5261	10	reference	reference	NN
cord-006229-7yoilsho	5261	11	sets	set	NNS
cord-006229-7yoilsho	5261	12	of	of	IN
cord-006229-7yoilsho	5261	13	Ryan	Ryan	NNP
cord-006229-7yoilsho	5261	14	et	et	NNP
cord-006229-7yoilsho	5261	15	al	al	NNP
cord-006229-7yoilsho	5261	16	.	.	NNP
cord-006229-7yoilsho	5261	17	,	,	,
cord-006229-7yoilsho	5261	18	142	142	CD
cord-006229-7yoilsho	5261	19	(	(	-LRB-
cord-006229-7yoilsho	5261	20	78.0	78.0	CD
cord-006229-7yoilsho	5261	21	%	%	NN
cord-006229-7yoilsho	5261	22	)	)	-RRB-
cord-006229-7yoilsho	5261	23	were	be	VBD
cord-006229-7yoilsho	5261	24	also	also	RB
cord-006229-7yoilsho	5261	25	available	available	JJ
cord-006229-7yoilsho	5261	26	on	on	IN
cord-006229-7yoilsho	5261	27	the	the	DT
cord-006229-7yoilsho	5261	28	German	german	JJ
cord-006229-7yoilsho	5261	29	drug	drug	NN
cord-006229-7yoilsho	5261	30	market	market	NN
cord-006229-7yoilsho	5261	31	and	and	CC
cord-006229-7yoilsho	5261	32	were	be	VBD
cord-006229-7yoilsho	5261	33	used	use	VBN
cord-006229-7yoilsho	5261	34	by	by	IN
cord-006229-7yoilsho	5261	35	at	at	RB
cord-006229-7yoilsho	5261	36	least	least	RBS
cord-006229-7yoilsho	5261	37	one	one	CD
cord-006229-7yoilsho	5261	38	insurant	insurant	NN
cord-006229-7yoilsho	5261	39	in	in	IN
cord-006229-7yoilsho	5261	40	the	the	DT
cord-006229-7yoilsho	5261	41	HRI	HRI	NNP
cord-006229-7yoilsho	5261	42	database	database	NN
cord-006229-7yoilsho	5261	43	during	during	IN
cord-006229-7yoilsho	5261	44	the	the	DT
cord-006229-7yoilsho	5261	45	study	study	NN
cord-006229-7yoilsho	5261	46	period	period	NN
cord-006229-7yoilsho	5261	47	.	.	.
cord-006229-7yoilsho	5262	1	A	a	DT
cord-006229-7yoilsho	5262	2	total	total	NN
cord-006229-7yoilsho	5262	3	of	of	IN
cord-006229-7yoilsho	5262	4	5,485,722	5,485,722	CD
cord-006229-7yoilsho	5262	5	index	index	NN
cord-006229-7yoilsho	5262	6	drug	drug	NN
cord-006229-7yoilsho	5262	7	initiators	initiator	NNS
cord-006229-7yoilsho	5262	8	were	be	VBD
cord-006229-7yoilsho	5262	9	included	include	VBN
cord-006229-7yoilsho	5262	10	in	in	IN
cord-006229-7yoilsho	5262	11	the	the	DT
cord-006229-7yoilsho	5262	12	analysis	analysis	NN
cord-006229-7yoilsho	5262	13	.	.	.
cord-006229-7yoilsho	5263	1	For	for	IN
cord-006229-7yoilsho	5263	2	a	a	DT
cord-006229-7yoilsho	5263	3	total	total	NN
cord-006229-7yoilsho	5263	4	of	of	IN
cord-006229-7yoilsho	5263	5	16	16	CD
cord-006229-7yoilsho	5263	6	index	index	NN
cord-006229-7yoilsho	5263	7	drugs	drug	NNS
cord-006229-7yoilsho	5263	8	,	,	,
cord-006229-7yoilsho	5263	9	a	a	DT
cord-006229-7yoilsho	5263	10	relative	relative	JJ
cord-006229-7yoilsho	5263	11	risk	risk	NN
cord-006229-7yoilsho	5263	12	of	of	IN
cord-006229-7yoilsho	5263	13	1.5	1.5	CD
cord-006229-7yoilsho	5263	14	could	could	MD
cord-006229-7yoilsho	5263	15	be	be	VB
cord-006229-7yoilsho	5263	16	detected	detect	VBN
cord-006229-7yoilsho	5263	17	with	with	IN
cord-006229-7yoilsho	5263	18	80	80	CD
cord-006229-7yoilsho	5263	19	%	%	NN
cord-006229-7yoilsho	5263	20	power	power	NN
cord-006229-7yoilsho	5263	21	.	.	.
cord-006229-7yoilsho	5264	1	The	the	DT
cord-006229-7yoilsho	5264	2	numbers	number	NNS
cord-006229-7yoilsho	5264	3	of	of	IN
cord-006229-7yoilsho	5264	4	index	index	NN
cord-006229-7yoilsho	5264	5	drugs	drug	NNS
cord-006229-7yoilsho	5264	6	for	for	IN
cord-006229-7yoilsho	5264	7	each	each	DT
cord-006229-7yoilsho	5264	8	of	of	IN
cord-006229-7yoilsho	5264	9	the	the	DT
cord-006229-7yoilsho	5264	10	outcomes	outcome	NNS
cord-006229-7yoilsho	5264	11	of	of	IN
cord-006229-7yoilsho	5264	12	interest	interest	NN
cord-006229-7yoilsho	5264	13	were	be	VBD
cord-006229-7yoilsho	5264	14	:	:	:
cord-006229-7yoilsho	5264	15	AMI	AMI	NNP
cord-006229-7yoilsho	5264	16	(	(	-LRB-
cord-006229-7yoilsho	5264	17	3	3	CD
cord-006229-7yoilsho	5264	18	positive	positive	JJ
cord-006229-7yoilsho	5264	19	controls	control	NNS
cord-006229-7yoilsho	5264	20	;	;	:
cord-006229-7yoilsho	5264	21	6	6	CD
cord-006229-7yoilsho	5264	22	negative	negative	JJ
cord-006229-7yoilsho	5264	23	controls	control	NNS
cord-006229-7yoilsho	5264	24	)	)	-RRB-
cord-006229-7yoilsho	5264	25	;	;	:
cord-006229-7yoilsho	5264	26	AKI	AKI	NNP
cord-006229-7yoilsho	5264	27	(	(	-LRB-
cord-006229-7yoilsho	5264	28	3	3	CD
cord-006229-7yoilsho	5264	29	positive	positive	JJ
cord-006229-7yoilsho	5264	30	controls	control	NNS
cord-006229-7yoilsho	5264	31	;	;	:
cord-006229-7yoilsho	5264	32	1	1	CD
cord-006229-7yoilsho	5264	33	negative	negative	JJ
cord-006229-7yoilsho	5264	34	control	control	NN
cord-006229-7yoilsho	5264	35	)	)	-RRB-
cord-006229-7yoilsho	5264	36	;	;	:
cord-006229-7yoilsho	5264	37	UGIB	UGIB	NNP
cord-006229-7yoilsho	5264	38	(	(	-LRB-
cord-006229-7yoilsho	5264	39	2	2	CD
cord-006229-7yoilsho	5264	40	positive	positive	JJ
cord-006229-7yoilsho	5264	41	controls	control	NNS
cord-006229-7yoilsho	5264	42	;	;	:
cord-006229-7yoilsho	5264	43	1	1	CD
cord-006229-7yoilsho	5264	44	negative	negative	JJ
cord-006229-7yoilsho	5264	45	control	control	NN
cord-006229-7yoilsho	5264	46	)	)	-RRB-
cord-006229-7yoilsho	5264	47	.	.	.
cord-006229-7yoilsho	5265	1	As	as	IN
cord-006229-7yoilsho	5265	2	the	the	DT
cord-006229-7yoilsho	5265	3	background	background	NN
cord-006229-7yoilsho	5265	4	incidence	incidence	NN
cord-006229-7yoilsho	5265	5	of	of	IN
cord-006229-7yoilsho	5265	6	ALI	ALI	NNP
cord-006229-7yoilsho	5265	7	was	be	VBD
cord-006229-7yoilsho	5265	8	low	low	JJ
cord-006229-7yoilsho	5265	9	,	,	,
cord-006229-7yoilsho	5265	10	no	no	DT
cord-006229-7yoilsho	5265	11	positive	positive	JJ
cord-006229-7yoilsho	5265	12	or	or	CC
cord-006229-7yoilsho	5265	13	negative	negative	JJ
cord-006229-7yoilsho	5265	14	control	control	NN
cord-006229-7yoilsho	5265	15	with	with	IN
cord-006229-7yoilsho	5265	16	sufficient	sufficient	JJ
cord-006229-7yoilsho	5265	17	power	power	NN
cord-006229-7yoilsho	5265	18	was	be	VBD
cord-006229-7yoilsho	5265	19	identified	identify	VBN
cord-006229-7yoilsho	5265	20	for	for	IN
cord-006229-7yoilsho	5265	21	this	this	DT
cord-006229-7yoilsho	5265	22	outcome	outcome	NN
cord-006229-7yoilsho	5265	23	.	.	.
cord-006229-7yoilsho	5266	1	Conclusions	conclusion	NNS
cord-006229-7yoilsho	5266	2	:	:	:
cord-006229-7yoilsho	5267	1	Using	use	VBG
cord-006229-7yoilsho	5267	2	the	the	DT
cord-006229-7yoilsho	5267	3	set	set	NN
cord-006229-7yoilsho	5267	4	of	of	IN
cord-006229-7yoilsho	5267	5	reference	reference	NN
cord-006229-7yoilsho	5267	6	drugs	drug	NNS
cord-006229-7yoilsho	5267	7	proposed	propose	VBN
cord-006229-7yoilsho	5267	8	by	by	IN
cord-006229-7yoilsho	5267	9	Ryan	Ryan	NNP
cord-006229-7yoilsho	5267	10	et	et	NNP
cord-006229-7yoilsho	5267	11	al	al	NNP
cord-006229-7yoilsho	5267	12	.	.	.
cord-006229-7yoilsho	5268	1	,	,	,
cord-006229-7yoilsho	5268	2	the	the	DT
cord-006229-7yoilsho	5268	3	number	number	NN
cord-006229-7yoilsho	5268	4	of	of	IN
cord-006229-7yoilsho	5268	5	drug	drug	NN
cord-006229-7yoilsho	5268	6	-	-	HYPH
cord-006229-7yoilsho	5268	7	event	event	NN
cord-006229-7yoilsho	5268	8	pairs	pair	NNS
cord-006229-7yoilsho	5268	9	with	with	IN
cord-006229-7yoilsho	5268	10	80	80	CD
cord-006229-7yoilsho	5268	11	%	%	NN
cord-006229-7yoilsho	5268	12	power	power	NN
cord-006229-7yoilsho	5268	13	to	to	TO
cord-006229-7yoilsho	5268	14	detect	detect	VB
cord-006229-7yoilsho	5268	15	a	a	DT
cord-006229-7yoilsho	5268	16	relative	relative	JJ
cord-006229-7yoilsho	5268	17	risk	risk	NN
cord-006229-7yoilsho	5268	18	of	of	IN
cord-006229-7yoilsho	5268	19	1.5	1.5	CD
cord-006229-7yoilsho	5268	20	was	be	VBD
cord-006229-7yoilsho	5268	21	low	low	JJ
cord-006229-7yoilsho	5268	22	,	,	,
cord-006229-7yoilsho	5268	23	despite	despite	IN
cord-006229-7yoilsho	5268	24	the	the	DT
cord-006229-7yoilsho	5268	25	magnitude	magnitude	NN
cord-006229-7yoilsho	5268	26	of	of	IN
cord-006229-7yoilsho	5268	27	the	the	DT
cord-006229-7yoilsho	5268	28	database	database	NN
cord-006229-7yoilsho	5268	29	used	use	VBN
cord-006229-7yoilsho	5268	30	.	.	.
cord-006229-7yoilsho	5269	1	This	this	DT
cord-006229-7yoilsho	5269	2	may	may	MD
cord-006229-7yoilsho	5269	3	be	be	VB
cord-006229-7yoilsho	5269	4	attributable	attributable	JJ
cord-006229-7yoilsho	5269	5	to	to	IN
cord-006229-7yoilsho	5269	6	differences	difference	NNS
cord-006229-7yoilsho	5269	7	of	of	IN
cord-006229-7yoilsho	5269	8	drug	drug	NN
cord-006229-7yoilsho	5269	9	exposure	exposure	NN
cord-006229-7yoilsho	5269	10	in	in	IN
cord-006229-7yoilsho	5269	11	Germany	Germany	NNP
cord-006229-7yoilsho	5269	12	and	and	CC
cord-006229-7yoilsho	5269	13	the	the	DT
cord-006229-7yoilsho	5269	14	US	US	NNP
cord-006229-7yoilsho	5269	15	.	.	.
cord-006229-7yoilsho	5270	1	Hence	hence	RB
cord-006229-7yoilsho	5270	2	,	,	,
cord-006229-7yoilsho	5270	3	an	an	DT
cord-006229-7yoilsho	5270	4	adaptation	adaptation	NN
cord-006229-7yoilsho	5270	5	of	of	IN
cord-006229-7yoilsho	5270	6	the	the	DT
cord-006229-7yoilsho	5270	7	drug	drug	NN
cord-006229-7yoilsho	5270	8	list	list	NN
cord-006229-7yoilsho	5270	9	to	to	IN
cord-006229-7yoilsho	5270	10	the	the	DT
cord-006229-7yoilsho	5270	11	German	german	JJ
cord-006229-7yoilsho	5270	12	drug	drug	NN
cord-006229-7yoilsho	5270	13	market	market	NN
cord-006229-7yoilsho	5270	14	and	and	CC
cord-006229-7yoilsho	5270	15	consumption	consumption	NN
cord-006229-7yoilsho	5270	16	data	datum	NNS
cord-006229-7yoilsho	5270	17	might	may	MD
cord-006229-7yoilsho	5270	18	be	be	VB
cord-006229-7yoilsho	5270	19	relevant	relevant	JJ
cord-006229-7yoilsho	5270	20	for	for	IN
cord-006229-7yoilsho	5270	21	future	future	JJ
cord-006229-7yoilsho	5270	22	evaluations	evaluation	NNS
cord-006229-7yoilsho	5270	23	of	of	IN
cord-006229-7yoilsho	5270	24	signal	signal	NN
cord-006229-7yoilsho	5270	25	detection	detection	NN
cord-006229-7yoilsho	5270	26	methods	method	NNS
cord-006229-7yoilsho	5270	27	using	use	VBG
cord-006229-7yoilsho	5270	28	German	german	JJ
cord-006229-7yoilsho	5270	29	databases	database	NNS
cord-006229-7yoilsho	5270	30	.	.	.
cord-006229-7yoilsho	5271	1	Correlation	correlation	NN
cord-006229-7yoilsho	5271	2	of	of	IN
cord-006229-7yoilsho	5271	3	Sativex	Sativex	NNP
cord-006229-7yoilsho	5271	4	™	™	IN
cord-006229-7yoilsho	5271	5	doses	dose	NNS
cord-006229-7yoilsho	5271	6	to	to	IN
cord-006229-7yoilsho	5271	7	steady	steady	JJ
cord-006229-7yoilsho	5271	8	state	state	NN
cord-006229-7yoilsho	5271	9	concentrations	concentration	NNS
cord-006229-7yoilsho	5271	10	of	of	IN
cord-006229-7yoilsho	5271	11	11-nor-9-carboxy-	11-nor-9-carboxy-	CD
cord-006229-7yoilsho	5271	12	Administration	Administration	NNP
cord-006229-7yoilsho	5271	13	of	of	IN
cord-006229-7yoilsho	5271	14	the	the	DT
cord-006229-7yoilsho	5271	15	oromucosal	oromucosal	NNP
cord-006229-7yoilsho	5271	16	spray	spray	NN
cord-006229-7yoilsho	5271	17	Sativex	Sativex	NNP
cord-006229-7yoilsho	5271	18	™	™	NN
cord-006229-7yoilsho	5271	19	represents	represent	VBZ
cord-006229-7yoilsho	5271	20	a	a	DT
cord-006229-7yoilsho	5271	21	therapy	therapy	NN
cord-006229-7yoilsho	5271	22	option	option	NN
cord-006229-7yoilsho	5271	23	for	for	IN
cord-006229-7yoilsho	5271	24	treatment	treatment	NN
cord-006229-7yoilsho	5271	25	of	of	IN
cord-006229-7yoilsho	5271	26	spasticity	spasticity	NN
cord-006229-7yoilsho	5271	27	in	in	IN
cord-006229-7yoilsho	5271	28	patients	patient	NNS
cord-006229-7yoilsho	5271	29	with	with	IN
cord-006229-7yoilsho	5271	30	multiple	multiple	JJ
cord-006229-7yoilsho	5271	31	sclerosis	sclerosis	NN
cord-006229-7yoilsho	5271	32	.	.	.
cord-006229-7yoilsho	5272	1	Sativex	Sativex	NNP
cord-006229-7yoilsho	5272	2	™	™	NN
cord-006229-7yoilsho	5272	3	is	be	VBZ
cord-006229-7yoilsho	5272	4	an	an	DT
cord-006229-7yoilsho	5272	5	extract	extract	NN
cord-006229-7yoilsho	5272	6	containing	contain	VBG
cord-006229-7yoilsho	5272	7	equal	equal	JJ
cord-006229-7yoilsho	5272	8	amounts	amount	NNS
cord-006229-7yoilsho	5272	9	of	of	IN
cord-006229-7yoilsho	5272	10	the	the	DT
cord-006229-7yoilsho	5272	11	Cannabis	Cannabis	NNP
cord-006229-7yoilsho	5272	12	-	-	HYPH
cord-006229-7yoilsho	5272	13	derived	derive	VBN
cord-006229-7yoilsho	5272	14	cannabinoids	cannabinoid	NNS
cord-006229-7yoilsho	5272	15	∆	∆	NN
cord-006229-7yoilsho	5272	16	9tetrahydrocannabinol	9tetrahydrocannabinol	CD
cord-006229-7yoilsho	5272	17	(	(	-LRB-
cord-006229-7yoilsho	5272	18	THC	THC	NNP
cord-006229-7yoilsho	5272	19	)	)	-RRB-
cord-006229-7yoilsho	5272	20	and	and	CC
cord-006229-7yoilsho	5272	21	cannabidiol	cannabidiol	FW
cord-006229-7yoilsho	5272	22	(	(	-LRB-
cord-006229-7yoilsho	5272	23	CBD	CBD	NNP
cord-006229-7yoilsho	5272	24	)	)	-RRB-
cord-006229-7yoilsho	5272	25	.	.	.
cord-006229-7yoilsho	5273	1	In	in	IN
cord-006229-7yoilsho	5273	2	cases	case	NNS
cord-006229-7yoilsho	5273	3	of	of	IN
cord-006229-7yoilsho	5273	4	Cannabis	Cannabis	NNP
cord-006229-7yoilsho	5273	5	abuse	abuse	NN
cord-006229-7yoilsho	5273	6	a	a	DT
cord-006229-7yoilsho	5273	7	long	long	JJ
cord-006229-7yoilsho	5273	8	elimination	elimination	NN
cord-006229-7yoilsho	5273	9	half	half	NN
cord-006229-7yoilsho	5273	10	life	life	NN
cord-006229-7yoilsho	5273	11	of	of	IN
cord-006229-7yoilsho	5273	12	some	some	DT
cord-006229-7yoilsho	5273	13	THC	thc	NN
cord-006229-7yoilsho	5273	14	metabolites	metabolite	NNS
cord-006229-7yoilsho	5273	15	is	be	VBZ
cord-006229-7yoilsho	5273	16	known	know	VBN
cord-006229-7yoilsho	5273	17	.	.	.
cord-006229-7yoilsho	5274	1	Therefore	therefore	RB
cord-006229-7yoilsho	5274	2	,	,	,
cord-006229-7yoilsho	5274	3	in	in	IN
cord-006229-7yoilsho	5274	4	patients	patient	NNS
cord-006229-7yoilsho	5274	5	receiving	receive	VBG
cord-006229-7yoilsho	5274	6	Sativex	Sativex	NNP
cord-006229-7yoilsho	5274	7	™	™	NN
cord-006229-7yoilsho	5274	8	,	,	,
cord-006229-7yoilsho	5274	9	the	the	DT
cord-006229-7yoilsho	5274	10	long	long	JJ
cord-006229-7yoilsho	5274	11	elimination	elimination	NN
cord-006229-7yoilsho	5274	12	half	half	NN
cord-006229-7yoilsho	5274	13	life	life	NN
cord-006229-7yoilsho	5274	14	of	of	IN
cord-006229-7yoilsho	5274	15	these	these	DT
cord-006229-7yoilsho	5274	16	metabolites	metabolite	NNS
cord-006229-7yoilsho	5274	17	should	should	MD
cord-006229-7yoilsho	5274	18	allow	allow	VB
cord-006229-7yoilsho	5274	19	a	a	DT
cord-006229-7yoilsho	5274	20	drug	drug	NN
cord-006229-7yoilsho	5274	21	monitoring	monitoring	NN
cord-006229-7yoilsho	5274	22	under	under	IN
cord-006229-7yoilsho	5274	23	conditions	condition	NNS
cord-006229-7yoilsho	5274	24	of	of	IN
cord-006229-7yoilsho	5274	25	steady	steady	JJ
cord-006229-7yoilsho	5274	26	state	state	NN
cord-006229-7yoilsho	5274	27	.	.	.
cord-006229-7yoilsho	5275	1	Due	due	IN
cord-006229-7yoilsho	5275	2	to	to	IN
cord-006229-7yoilsho	5275	3	the	the	DT
cord-006229-7yoilsho	5275	4	fact	fact	NN
cord-006229-7yoilsho	5275	5	that	that	IN
cord-006229-7yoilsho	5275	6	immunologically	immunologically	RB
cord-006229-7yoilsho	5275	7	based	base	VBN
cord-006229-7yoilsho	5275	8	methods	method	NNS
cord-006229-7yoilsho	5275	9	for	for	IN
cord-006229-7yoilsho	5275	10	THC	thc	NN
cord-006229-7yoilsho	5275	11	determination	determination	NN
cord-006229-7yoilsho	5275	12	are	be	VBP
cord-006229-7yoilsho	5275	13	very	very	RB
cord-006229-7yoilsho	5275	14	common	common	JJ
cord-006229-7yoilsho	5275	15	in	in	IN
cord-006229-7yoilsho	5275	16	medical	medical	JJ
cord-006229-7yoilsho	5275	17	chemistry	chemistry	NN
cord-006229-7yoilsho	5275	18	,	,	,
cord-006229-7yoilsho	5275	19	a	a	DT
cord-006229-7yoilsho	5275	20	monitoring	monitoring	NN
cord-006229-7yoilsho	5275	21	might	may	MD
cord-006229-7yoilsho	5275	22	be	be	VB
cord-006229-7yoilsho	5275	23	simply	simply	RB
cord-006229-7yoilsho	5275	24	performed	perform	VBN
cord-006229-7yoilsho	5275	25	even	even	RB
cord-006229-7yoilsho	5275	26	in	in	IN
cord-006229-7yoilsho	5275	27	patients	patient	NNS
cord-006229-7yoilsho	5275	28	under	under	IN
cord-006229-7yoilsho	5275	29	Sativex	Sativex	NNP
cord-006229-7yoilsho	5275	30	™	™	NN
cord-006229-7yoilsho	5275	31	therapy	therapy	NN
cord-006229-7yoilsho	5275	32	.	.	.
cord-006229-7yoilsho	5276	1	In	in	IN
cord-006229-7yoilsho	5276	2	a	a	DT
cord-006229-7yoilsho	5276	3	preliminary	preliminary	JJ
cord-006229-7yoilsho	5276	4	observational	observational	JJ
cord-006229-7yoilsho	5276	5	study	study	NN
cord-006229-7yoilsho	5276	6	11-nor-9-carboxy-∆	11-nor-9-carboxy-∆	CD
cord-006229-7yoilsho	5276	7	9	9	CD
cord-006229-7yoilsho	5276	8	-THC	-THC	-LRB-
cord-006229-7yoilsho	5276	9	(	(	-LRB-
cord-006229-7yoilsho	5276	10	THC	thc	NN
cord-006229-7yoilsho	5276	11	-	-	HYPH
cord-006229-7yoilsho	5276	12	COOH	COOH	NNP
cord-006229-7yoilsho	5276	13	)	)	-RRB-
cord-006229-7yoilsho	5276	14	concentrations	concentration	NNS
cord-006229-7yoilsho	5276	15	were	be	VBD
cord-006229-7yoilsho	5276	16	measured	measure	VBN
cord-006229-7yoilsho	5276	17	with	with	IN
cord-006229-7yoilsho	5276	18	a	a	DT
cord-006229-7yoilsho	5276	19	commercial	commercial	JJ
cord-006229-7yoilsho	5276	20	immunoassay	immunoassay	NN
cord-006229-7yoilsho	5276	21	in	in	IN
cord-006229-7yoilsho	5276	22	urine	urine	NN
cord-006229-7yoilsho	5276	23	samples	sample	NNS
cord-006229-7yoilsho	5276	24	of	of	IN
cord-006229-7yoilsho	5276	25	16	16	CD
cord-006229-7yoilsho	5276	26	patients	patient	NNS
cord-006229-7yoilsho	5276	27	with	with	IN
cord-006229-7yoilsho	5276	28	multiple	multiple	JJ
cord-006229-7yoilsho	5276	29	sclerosis	sclerosis	NN
cord-006229-7yoilsho	5276	30	obtaining	obtain	VBG
cord-006229-7yoilsho	5276	31	Sativex	Sativex	NNP
cord-006229-7yoilsho	5276	32	™	™	NN
cord-006229-7yoilsho	5276	33	.	.	.
cord-006229-7yoilsho	5277	1	In	in	IN
cord-006229-7yoilsho	5277	2	addition	addition	NN
cord-006229-7yoilsho	5277	3	,	,	,
cord-006229-7yoilsho	5277	4	THC	thc	NN
cord-006229-7yoilsho	5277	5	-	-	HYPH
cord-006229-7yoilsho	5277	6	COOH	COOH	NNP
cord-006229-7yoilsho	5277	7	,	,	,
cord-006229-7yoilsho	5277	8	THC	THC	NNP
cord-006229-7yoilsho	5277	9	,	,	,
cord-006229-7yoilsho	5277	10	CBD	CBD	NNP
cord-006229-7yoilsho	5277	11	as	as	RB
cord-006229-7yoilsho	5277	12	well	well	RB
cord-006229-7yoilsho	5277	13	as	as	IN
cord-006229-7yoilsho	5277	14	the	the	DT
cord-006229-7yoilsho	5277	15	hydroxy	hydroxy	JJ
cord-006229-7yoilsho	5277	16	metabolites	metabolite	NNS
cord-006229-7yoilsho	5277	17	of	of	IN
cord-006229-7yoilsho	5277	18	THC	THC	NNP
cord-006229-7yoilsho	5277	19	and	and	CC
cord-006229-7yoilsho	5277	20	CBD	CBD	NNP
cord-006229-7yoilsho	5277	21	were	be	VBD
cord-006229-7yoilsho	5277	22	measured	measure	VBN
cord-006229-7yoilsho	5277	23	by	by	IN
cord-006229-7yoilsho	5277	24	GC	GC	NNP
cord-006229-7yoilsho	5277	25	/	/	SYM
cord-006229-7yoilsho	5277	26	MS	MS	NNP
cord-006229-7yoilsho	5277	27	in	in	IN
cord-006229-7yoilsho	5277	28	urine	urine	NN
cord-006229-7yoilsho	5277	29	and	and	CC
cord-006229-7yoilsho	5277	30	blood	blood	NN
cord-006229-7yoilsho	5277	31	samples	sample	NNS
cord-006229-7yoilsho	5277	32	.	.	.
cord-006229-7yoilsho	5278	1	Using	use	VBG
cord-006229-7yoilsho	5278	2	this	this	DT
cord-006229-7yoilsho	5278	3	analytical	analytical	JJ
cord-006229-7yoilsho	5278	4	technique	technique	NN
cord-006229-7yoilsho	5278	5	,	,	,
cord-006229-7yoilsho	5278	6	only	only	RB
cord-006229-7yoilsho	5278	7	an	an	DT
cord-006229-7yoilsho	5278	8	excessive	excessive	JJ
cord-006229-7yoilsho	5278	9	dosing	dosing	NN
cord-006229-7yoilsho	5278	10	(	(	-LRB-
cord-006229-7yoilsho	5278	11	as	as	IN
cord-006229-7yoilsho	5278	12	compared	compare	VBN
cord-006229-7yoilsho	5278	13	to	to	IN
cord-006229-7yoilsho	5278	14	the	the	DT
cord-006229-7yoilsho	5278	15	declaration	declaration	NN
cord-006229-7yoilsho	5278	16	by	by	IN
cord-006229-7yoilsho	5278	17	the	the	DT
cord-006229-7yoilsho	5278	18	patient	patient	NN
cord-006229-7yoilsho	5278	19	)	)	-RRB-
cord-006229-7yoilsho	5278	20	can	can	MD
cord-006229-7yoilsho	5278	21	be	be	VB
cord-006229-7yoilsho	5278	22	detected	detect	VBN
cord-006229-7yoilsho	5278	23	.	.	.
cord-006229-7yoilsho	5279	1	As	as	IN
cord-006229-7yoilsho	5279	2	a	a	DT
cord-006229-7yoilsho	5279	3	result	result	NN
cord-006229-7yoilsho	5279	4	of	of	IN
cord-006229-7yoilsho	5279	5	this	this	DT
cord-006229-7yoilsho	5279	6	approach	approach	NN
cord-006229-7yoilsho	5279	7	,	,	,
cord-006229-7yoilsho	5279	8	THC	THC	NNP
cord-006229-7yoilsho	5279	9	-	-	HYPH
cord-006229-7yoilsho	5279	10	COOH	COOH	NNP
cord-006229-7yoilsho	5279	11	concentrations	concentration	NNS
cord-006229-7yoilsho	5279	12	determined	determine	VBN
cord-006229-7yoilsho	5279	13	by	by	IN
cord-006229-7yoilsho	5279	14	the	the	DT
cord-006229-7yoilsho	5279	15	immunoassay	immunoassay	NN
cord-006229-7yoilsho	5279	16	were	be	VBD
cord-006229-7yoilsho	5279	17	found	find	VBN
cord-006229-7yoilsho	5279	18	not	not	RB
cord-006229-7yoilsho	5279	19	to	to	TO
cord-006229-7yoilsho	5279	20	correlate	correlate	VB
cord-006229-7yoilsho	5279	21	to	to	IN
cord-006229-7yoilsho	5279	22	the	the	DT
cord-006229-7yoilsho	5279	23	daily	daily	JJ
cord-006229-7yoilsho	5279	24	applicated	applicated	JJ
cord-006229-7yoilsho	5279	25	amount	amount	NN
cord-006229-7yoilsho	5279	26	of	of	IN
cord-006229-7yoilsho	5279	27	Sativex	Sativex	NNP
cord-006229-7yoilsho	5279	28	™	™	NN
cord-006229-7yoilsho	5279	29	as	as	IN
cord-006229-7yoilsho	5279	30	indicated	indicate	VBN
cord-006229-7yoilsho	5279	31	by	by	IN
cord-006229-7yoilsho	5279	32	the	the	DT
cord-006229-7yoilsho	5279	33	patients	patient	NNS
cord-006229-7yoilsho	5279	34	(	(	-LRB-
cord-006229-7yoilsho	5279	35	Spearman	Spearman	NNP
cord-006229-7yoilsho	5279	36	rang	ring	VBD
cord-006229-7yoilsho	5279	37	order	order	NN
cord-006229-7yoilsho	5279	38	test	test	NN
cord-006229-7yoilsho	5279	39	:	:	:
cord-006229-7yoilsho	5280	1	p	p	NN
cord-006229-7yoilsho	5280	2	>	>	XX
cord-006229-7yoilsho	5280	3	0.05	0.05	CD
cord-006229-7yoilsho	5280	4	)	)	-RRB-
cord-006229-7yoilsho	5280	5	.	.	.
cord-006229-7yoilsho	5281	1	Two	two	CD
cord-006229-7yoilsho	5281	2	patients	patient	NNS
cord-006229-7yoilsho	5281	3	mentioned	mention	VBD
cord-006229-7yoilsho	5281	4	not	not	RB
cord-006229-7yoilsho	5281	5	to	to	TO
cord-006229-7yoilsho	5281	6	have	have	VB
cord-006229-7yoilsho	5281	7	taken	take	VBN
cord-006229-7yoilsho	5281	8	Sativex	Sativex	NNP
cord-006229-7yoilsho	5281	9	™	™	NN
cord-006229-7yoilsho	5281	10	on	on	IN
cord-006229-7yoilsho	5281	11	the	the	DT
cord-006229-7yoilsho	5281	12	day	day	NN
cord-006229-7yoilsho	5281	13	the	the	DT
cord-006229-7yoilsho	5281	14	samples	sample	NNS
cord-006229-7yoilsho	5281	15	had	have	VBD
cord-006229-7yoilsho	5281	16	been	be	VBN
cord-006229-7yoilsho	5281	17	taken	take	VBN
cord-006229-7yoilsho	5281	18	,	,	,
cord-006229-7yoilsho	5281	19	and	and	CC
cord-006229-7yoilsho	5281	20	one	one	CD
cord-006229-7yoilsho	5281	21	patient	patient	NN
cord-006229-7yoilsho	5281	22	predicated	predicate	VBD
cord-006229-7yoilsho	5281	23	an	an	DT
cord-006229-7yoilsho	5281	24	additional	additional	JJ
cord-006229-7yoilsho	5281	25	Cannabis	Cannabis	NNP
cord-006229-7yoilsho	5281	26	abuse	abuse	NN
cord-006229-7yoilsho	5281	27	.	.	.
cord-006229-7yoilsho	5282	1	In	in	IN
cord-006229-7yoilsho	5282	2	three	three	CD
cord-006229-7yoilsho	5282	3	patients	patient	NNS
cord-006229-7yoilsho	5282	4	the	the	DT
cord-006229-7yoilsho	5282	5	immunological	immunological	JJ
cord-006229-7yoilsho	5282	6	THC	thc	NN
cord-006229-7yoilsho	5282	7	-	-	HYPH
cord-006229-7yoilsho	5282	8	COOH	COOH	NNP
cord-006229-7yoilsho	5282	9	determination	determination	NN
cord-006229-7yoilsho	5282	10	was	be	VBD
cord-006229-7yoilsho	5282	11	negative	negative	JJ
cord-006229-7yoilsho	5282	12	or	or	CC
cord-006229-7yoilsho	5282	13	nearly	nearly	RB
cord-006229-7yoilsho	5282	14	negative	negative	JJ
cord-006229-7yoilsho	5282	15	.	.	.
cord-006229-7yoilsho	5283	1	Interpretation	interpretation	NN
cord-006229-7yoilsho	5283	2	of	of	IN
cord-006229-7yoilsho	5283	3	the	the	DT
cord-006229-7yoilsho	5283	4	data	data	NN
cord-006229-7yoilsho	5283	5	is	be	VBZ
cord-006229-7yoilsho	5283	6	hampered	hamper	VBN
cord-006229-7yoilsho	5283	7	by	by	IN
cord-006229-7yoilsho	5283	8	the	the	DT
cord-006229-7yoilsho	5283	9	fact	fact	NN
cord-006229-7yoilsho	5283	10	that	that	IN
cord-006229-7yoilsho	5283	11	an	an	DT
cord-006229-7yoilsho	5283	12	incorrect	incorrect	JJ
cord-006229-7yoilsho	5283	13	declaration	declaration	NN
cord-006229-7yoilsho	5283	14	of	of	IN
cord-006229-7yoilsho	5283	15	Sativex	Sativex	NNP
cord-006229-7yoilsho	5283	16	™	™	NN
cord-006229-7yoilsho	5283	17	applications	application	NNS
cord-006229-7yoilsho	5283	18	by	by	IN
cord-006229-7yoilsho	5283	19	the	the	DT
cord-006229-7yoilsho	5283	20	patients	patient	NNS
cord-006229-7yoilsho	5283	21	can	can	MD
cord-006229-7yoilsho	5283	22	not	not	RB
cord-006229-7yoilsho	5283	23	be	be	VB
cord-006229-7yoilsho	5283	24	excluded	exclude	VBN
cord-006229-7yoilsho	5283	25	.	.	.
cord-006229-7yoilsho	5284	1	Introduction	introduction	NN
cord-006229-7yoilsho	5284	2	:	:	:
cord-006229-7yoilsho	5285	1	Learning	learn	VBG
cord-006229-7yoilsho	5285	2	analytics	analytic	NNS
cord-006229-7yoilsho	5285	3	seeks	seek	VBZ
cord-006229-7yoilsho	5285	4	to	to	TO
cord-006229-7yoilsho	5285	5	enhance	enhance	VB
cord-006229-7yoilsho	5285	6	the	the	DT
cord-006229-7yoilsho	5285	7	learning	learning	NN
cord-006229-7yoilsho	5285	8	process	process	NN
cord-006229-7yoilsho	5285	9	through	through	IN
cord-006229-7yoilsho	5285	10	systematic	systematic	JJ
cord-006229-7yoilsho	5285	11	measurement	measurement	NN
cord-006229-7yoilsho	5285	12	and	and	CC
cord-006229-7yoilsho	5285	13	analysis	analysis	NN
cord-006229-7yoilsho	5285	14	of	of	IN
cord-006229-7yoilsho	5285	15	learning	learn	VBG
cord-006229-7yoilsho	5285	16	related	related	JJ
cord-006229-7yoilsho	5285	17	data	datum	NNS
cord-006229-7yoilsho	5285	18	to	to	TO
cord-006229-7yoilsho	5285	19	provide	provide	VB
cord-006229-7yoilsho	5285	20	informative	informative	JJ
cord-006229-7yoilsho	5285	21	feedback	feedback	NN
cord-006229-7yoilsho	5285	22	for	for	IN
cord-006229-7yoilsho	5285	23	students	student	NNS
cord-006229-7yoilsho	5285	24	and	and	CC
cord-006229-7yoilsho	5285	25	lecturers	lecturer	NNS
cord-006229-7yoilsho	5285	26	.	.	.
cord-006229-7yoilsho	5286	1	However	however	RB
cord-006229-7yoilsho	5286	2	,	,	,
cord-006229-7yoilsho	5286	3	which	which	WDT
cord-006229-7yoilsho	5286	4	parameters	parameter	NNS
cord-006229-7yoilsho	5286	5	have	have	VBP
cord-006229-7yoilsho	5286	6	the	the	DT
cord-006229-7yoilsho	5286	7	best	good	JJS
cord-006229-7yoilsho	5286	8	predictive	predictive	JJ
cord-006229-7yoilsho	5286	9	power	power	NN
cord-006229-7yoilsho	5286	10	for	for	IN
cord-006229-7yoilsho	5286	11	academic	academic	JJ
cord-006229-7yoilsho	5286	12	performance	performance	NN
cord-006229-7yoilsho	5286	13	remains	remain	VBZ
cord-006229-7yoilsho	5286	14	to	to	TO
cord-006229-7yoilsho	5286	15	be	be	VB
cord-006229-7yoilsho	5286	16	elucidated	elucidate	VBN
cord-006229-7yoilsho	5286	17	.	.	.
cord-006229-7yoilsho	5287	1	Objective	objective	NN
cord-006229-7yoilsho	5287	2	:	:	:
cord-006229-7yoilsho	5288	1	To	to	TO
cord-006229-7yoilsho	5288	2	analyze	analyze	VB
cord-006229-7yoilsho	5288	3	the	the	DT
cord-006229-7yoilsho	5288	4	potential	potential	NN
cord-006229-7yoilsho	5288	5	of	of	IN
cord-006229-7yoilsho	5288	6	different	different	JJ
cord-006229-7yoilsho	5288	7	learning	learning	NN
cord-006229-7yoilsho	5288	8	analytics	analytic	NNS
cord-006229-7yoilsho	5288	9	parameters	parameter	NNS
cord-006229-7yoilsho	5288	10	to	to	TO
cord-006229-7yoilsho	5288	11	predict	predict	VB
cord-006229-7yoilsho	5288	12	exam	exam	NN
cord-006229-7yoilsho	5288	13	performance	performance	NN
cord-006229-7yoilsho	5288	14	in	in	IN
cord-006229-7yoilsho	5288	15	undergraduate	undergraduate	JJ
cord-006229-7yoilsho	5288	16	medical	medical	JJ
cord-006229-7yoilsho	5288	17	education	education	NN
cord-006229-7yoilsho	5288	18	of	of	IN
cord-006229-7yoilsho	5288	19	pharmacology	pharmacology	NN
cord-006229-7yoilsho	5288	20	.	.	.
cord-006229-7yoilsho	5289	1	Methods	method	NNS
cord-006229-7yoilsho	5289	2	and	and	CC
cord-006229-7yoilsho	5289	3	results	result	NNS
cord-006229-7yoilsho	5289	4	:	:	:
cord-006229-7yoilsho	5289	5	Hypertext	Hypertext	NNP
cord-006229-7yoilsho	5289	6	Preprocessor	preprocessor	NN
cord-006229-7yoilsho	5289	7	(	(	-LRB-
cord-006229-7yoilsho	5289	8	PHP	PHP	NNP
cord-006229-7yoilsho	5289	9	)	)	-RRB-
cord-006229-7yoilsho	5289	10	as	as	IN
cord-006229-7yoilsho	5289	11	server	server	NN
cord-006229-7yoilsho	5289	12	-	-	HYPH
cord-006229-7yoilsho	5289	13	side	side	NN
cord-006229-7yoilsho	5289	14	scripting	scripting	NN
cord-006229-7yoilsho	5289	15	language	language	NN
cord-006229-7yoilsho	5289	16	was	be	VBD
cord-006229-7yoilsho	5289	17	used	use	VBN
cord-006229-7yoilsho	5289	18	to	to	TO
cord-006229-7yoilsho	5289	19	develop	develop	VB
cord-006229-7yoilsho	5289	20	a	a	DT
cord-006229-7yoilsho	5289	21	learning	learn	VBG
cord-006229-7yoilsho	5289	22	analytics	analytic	NNS
cord-006229-7yoilsho	5289	23	platform	platform	NN
cord-006229-7yoilsho	5289	24	linked	link	VBN
cord-006229-7yoilsho	5289	25	to	to	IN
cord-006229-7yoilsho	5289	26	a	a	DT
cord-006229-7yoilsho	5289	27	My	-PRON-	PRP$
cord-006229-7yoilsho	5289	28	Structured	Structured	NNP
cord-006229-7yoilsho	5289	29	Query	query	NN
cord-006229-7yoilsho	5289	30	Language	language	NN
cord-006229-7yoilsho	5289	31	(	(	-LRB-
cord-006229-7yoilsho	5289	32	MySQL	MySQL	NNP
cord-006229-7yoilsho	5289	33	)	)	-RRB-
cord-006229-7yoilsho	5289	34	database	database	NN
cord-006229-7yoilsho	5289	35	for	for	IN
cord-006229-7yoilsho	5289	36	storage	storage	NN
cord-006229-7yoilsho	5289	37	and	and	CC
cord-006229-7yoilsho	5289	38	analysis	analysis	NN
cord-006229-7yoilsho	5289	39	of	of	IN
cord-006229-7yoilsho	5289	40	data	datum	NNS
cord-006229-7yoilsho	5289	41	(	(	-LRB-
cord-006229-7yoilsho	5289	42	www.tumanalytics.de	www.tumanalytics.de	NNP
cord-006229-7yoilsho	5289	43	)	)	-RRB-
cord-006229-7yoilsho	5289	44	.	.	.
cord-006229-7yoilsho	5290	1	The	the	DT
cord-006229-7yoilsho	5290	2	database	database	NN
cord-006229-7yoilsho	5290	3	consisted	consist	VBD
cord-006229-7yoilsho	5290	4	of	of	IN
cord-006229-7yoilsho	5290	5	440	440	CD
cord-006229-7yoilsho	5290	6	lecturer	lecturer	NN
cord-006229-7yoilsho	5290	7	-	-	HYPH
cord-006229-7yoilsho	5290	8	authored	author	VBN
cord-006229-7yoilsho	5290	9	multiple	multiple	JJ
cord-006229-7yoilsho	5290	10	choice	choice	NN
cord-006229-7yoilsho	5290	11	questions	question	NNS
cord-006229-7yoilsho	5290	12	that	that	WDT
cord-006229-7yoilsho	5290	13	were	be	VBD
cord-006229-7yoilsho	5290	14	made	make	VBN
cord-006229-7yoilsho	5290	15	available	available	JJ
cord-006229-7yoilsho	5290	16	to	to	IN
cord-006229-7yoilsho	5290	17	a	a	DT
cord-006229-7yoilsho	5290	18	cohort	cohort	NN
cord-006229-7yoilsho	5290	19	of	of	IN
cord-006229-7yoilsho	5290	20	undergraduate	undergraduate	JJ
cord-006229-7yoilsho	5290	21	medical	medical	JJ
cord-006229-7yoilsho	5290	22	students	student	NNS
cord-006229-7yoilsho	5290	23	enrolled	enrol	VBN
cord-006229-7yoilsho	5290	24	in	in	IN
cord-006229-7yoilsho	5290	25	a	a	DT
cord-006229-7yoilsho	5290	26	pharmacology	pharmacology	NN
cord-006229-7yoilsho	5290	27	course	course	NN
cord-006229-7yoilsho	5290	28	(	(	-LRB-
cord-006229-7yoilsho	5290	29	winter	winter	NN
cord-006229-7yoilsho	5290	30	term	term	NN
cord-006229-7yoilsho	5290	31	2014/15	2014/15	CD
cord-006229-7yoilsho	5290	32	)	)	-RRB-
cord-006229-7yoilsho	5290	33	at	at	IN
cord-006229-7yoilsho	5290	34	Technische	Technische	NNP
cord-006229-7yoilsho	5290	35	Universität	Universität	NNP
cord-006229-7yoilsho	5290	36	München	München	NNP
cord-006229-7yoilsho	5290	37	(	(	-LRB-
cord-006229-7yoilsho	5290	38	TUM	TUM	NNP
cord-006229-7yoilsho	5290	39	)	)	-RRB-
cord-006229-7yoilsho	5290	40	.	.	.
cord-006229-7yoilsho	5291	1	The	the	DT
cord-006229-7yoilsho	5291	2	course	course	NN
cord-006229-7yoilsho	5291	3	consisted	consist	VBD
cord-006229-7yoilsho	5291	4	of	of	IN
cord-006229-7yoilsho	5291	5	a	a	DT
cord-006229-7yoilsho	5291	6	28-day	28-day	CD
cord-006229-7yoilsho	5291	7	teaching	teaching	NN
cord-006229-7yoilsho	5291	8	period	period	NN
cord-006229-7yoilsho	5291	9	,	,	,
cord-006229-7yoilsho	5291	10	followed	follow	VBN
cord-006229-7yoilsho	5291	11	by	by	IN
cord-006229-7yoilsho	5291	12	a	a	DT
cord-006229-7yoilsho	5291	13	12-day	12-day	CD
cord-006229-7yoilsho	5291	14	self	self	NN
cord-006229-7yoilsho	5291	15	-	-	HYPH
cord-006229-7yoilsho	5291	16	study	study	NN
cord-006229-7yoilsho	5291	17	period	period	NN
cord-006229-7yoilsho	5291	18	and	and	CC
cord-006229-7yoilsho	5291	19	a	a	DT
cord-006229-7yoilsho	5291	20	final	final	JJ
cord-006229-7yoilsho	5291	21	written	write	VBN
cord-006229-7yoilsho	5291	22	exam	exam	NN
cord-006229-7yoilsho	5291	23	.	.	.
cord-006229-7yoilsho	5292	1	Students	student	NNS
cord-006229-7yoilsho	5292	2	'	'	POS
cord-006229-7yoilsho	5292	3	assessment	assessment	NN
cord-006229-7yoilsho	5292	4	data	datum	NNS
cord-006229-7yoilsho	5292	5	of	of	IN
cord-006229-7yoilsho	5292	6	TUManalytics	tumanalytic	NNS
cord-006229-7yoilsho	5292	7	was	be	VBD
cord-006229-7yoilsho	5292	8	collected	collect	VBN
cord-006229-7yoilsho	5292	9	during	during	IN
cord-006229-7yoilsho	5292	10	the	the	DT
cord-006229-7yoilsho	5292	11	self	self	NN
cord-006229-7yoilsho	5292	12	-	-	HYPH
cord-006229-7yoilsho	5292	13	study	study	NN
cord-006229-7yoilsho	5292	14	period	period	NN
cord-006229-7yoilsho	5292	15	and	and	CC
cord-006229-7yoilsho	5292	16	correlated	correlate	VBD
cord-006229-7yoilsho	5292	17	to	to	IN
cord-006229-7yoilsho	5292	18	the	the	DT
cord-006229-7yoilsho	5292	19	individual	individual	JJ
cord-006229-7yoilsho	5292	20	exam	exam	NN
cord-006229-7yoilsho	5292	21	results	result	NNS
cord-006229-7yoilsho	5292	22	in	in	IN
cord-006229-7yoilsho	5292	23	a	a	DT
cord-006229-7yoilsho	5292	24	pseudonymized	pseudonymized	JJ
cord-006229-7yoilsho	5292	25	manner	manner	NN
cord-006229-7yoilsho	5292	26	.	.	.
cord-006229-7yoilsho	5293	1	A	a	DT
cord-006229-7yoilsho	5293	2	total	total	NN
cord-006229-7yoilsho	5293	3	of	of	IN
cord-006229-7yoilsho	5293	4	224	224	CD
cord-006229-7yoilsho	5293	5	out	out	IN
cord-006229-7yoilsho	5293	6	of	of	IN
cord-006229-7yoilsho	5293	7	393	393	CD
cord-006229-7yoilsho	5293	8	(	(	-LRB-
cord-006229-7yoilsho	5293	9	57	57	CD
cord-006229-7yoilsho	5293	10	%	%	NN
cord-006229-7yoilsho	5293	11	)	)	-RRB-
cord-006229-7yoilsho	5293	12	students	student	NNS
cord-006229-7yoilsho	5293	13	participated	participate	VBD
cord-006229-7yoilsho	5293	14	in	in	IN
cord-006229-7yoilsho	5293	15	the	the	DT
cord-006229-7yoilsho	5293	16	study	study	NN
cord-006229-7yoilsho	5293	17	.	.	.
cord-006229-7yoilsho	5294	1	The	the	DT
cord-006229-7yoilsho	5294	2	coefficient	coefficient	NN
cord-006229-7yoilsho	5294	3	of	of	IN
cord-006229-7yoilsho	5294	4	multiple	multiple	JJ
cord-006229-7yoilsho	5294	5	correlation	correlation	NN
cord-006229-7yoilsho	5294	6	(	(	-LRB-
cord-006229-7yoilsho	5294	7	R	r	NN
cord-006229-7yoilsho	5294	8	)	)	-RRB-
cord-006229-7yoilsho	5294	9	was	be	VBD
cord-006229-7yoilsho	5294	10	calculated	calculate	VBN
cord-006229-7yoilsho	5294	11	for	for	IN
cord-006229-7yoilsho	5294	12	different	different	JJ
cord-006229-7yoilsho	5294	13	parameters	parameter	NNS
cord-006229-7yoilsho	5294	14	in	in	IN
cord-006229-7yoilsho	5294	15	relation	relation	NN
cord-006229-7yoilsho	5294	16	to	to	IN
cord-006229-7yoilsho	5294	17	exam	exam	NN
cord-006229-7yoilsho	5294	18	results	result	NNS
cord-006229-7yoilsho	5294	19	as	as	IN
cord-006229-7yoilsho	5294	20	a	a	DT
cord-006229-7yoilsho	5294	21	measure	measure	NN
cord-006229-7yoilsho	5294	22	of	of	IN
cord-006229-7yoilsho	5294	23	predictive	predictive	JJ
cord-006229-7yoilsho	5294	24	power	power	NN
cord-006229-7yoilsho	5294	25	.	.	.
cord-006229-7yoilsho	5295	1	Of	of	IN
cord-006229-7yoilsho	5295	2	different	different	JJ
cord-006229-7yoilsho	5295	3	parameters	parameter	NNS
cord-006229-7yoilsho	5295	4	investigated	investigate	VBN
cord-006229-7yoilsho	5295	5	,	,	,
cord-006229-7yoilsho	5295	6	the	the	DT
cord-006229-7yoilsho	5295	7	total	total	JJ
cord-006229-7yoilsho	5295	8	score	score	NN
cord-006229-7yoilsho	5295	9	and	and	CC
cord-006229-7yoilsho	5295	10	the	the	DT
cord-006229-7yoilsho	5295	11	score	score	NN
cord-006229-7yoilsho	5295	12	of	of	IN
cord-006229-7yoilsho	5295	13	the	the	DT
cord-006229-7yoilsho	5295	14	first	first	JJ
cord-006229-7yoilsho	5295	15	attempt	attempt	NN
cord-006229-7yoilsho	5295	16	in	in	IN
cord-006229-7yoilsho	5295	17	TUManalytics	tumanalytic	NNS
cord-006229-7yoilsho	5295	18	had	have	VBD
cord-006229-7yoilsho	5295	19	the	the	DT
cord-006229-7yoilsho	5295	20	highest	high	JJS
cord-006229-7yoilsho	5295	21	positive	positive	JJ
cord-006229-7yoilsho	5295	22	correlation	correlation	NN
cord-006229-7yoilsho	5295	23	with	with	IN
cord-006229-7yoilsho	5295	24	exam	exam	NN
cord-006229-7yoilsho	5295	25	performance	performance	NN
cord-006229-7yoilsho	5295	26	(	(	-LRB-
cord-006229-7yoilsho	5295	27	Abb	Abb	NNP
cord-006229-7yoilsho	5295	28	.	.	.
cord-006229-7yoilsho	5295	29	1	1	CD
cord-006229-7yoilsho	5295	30	)	)	-RRB-
cord-006229-7yoilsho	5295	31	.	.	.
cord-006229-7yoilsho	5296	1	No	no	DT
cord-006229-7yoilsho	5296	2	sex	sex	NN
cord-006229-7yoilsho	5296	3	-	-	HYPH
cord-006229-7yoilsho	5296	4	specific	specific	JJ
cord-006229-7yoilsho	5296	5	differences	difference	NNS
cord-006229-7yoilsho	5296	6	were	be	VBD
cord-006229-7yoilsho	5296	7	observed	observe	VBN
cord-006229-7yoilsho	5296	8	.	.	.
cord-006229-7yoilsho	5297	1	Summary	Summary	NNP
cord-006229-7yoilsho	5297	2	and	and	CC
cord-006229-7yoilsho	5297	3	Conclusion	conclusion	NN
cord-006229-7yoilsho	5297	4	:	:	:
cord-006229-7yoilsho	5297	5	In	in	IN
cord-006229-7yoilsho	5297	6	this	this	DT
cord-006229-7yoilsho	5297	7	study	study	NN
cord-006229-7yoilsho	5297	8	we	-PRON-	PRP
cord-006229-7yoilsho	5297	9	systematically	systematically	RB
cord-006229-7yoilsho	5297	10	investigated	investigate	VBD
cord-006229-7yoilsho	5297	11	the	the	DT
cord-006229-7yoilsho	5297	12	potential	potential	NN
cord-006229-7yoilsho	5297	13	of	of	IN
cord-006229-7yoilsho	5297	14	different	different	JJ
cord-006229-7yoilsho	5297	15	learning	learning	NN
cord-006229-7yoilsho	5297	16	analytics	analytic	NNS
cord-006229-7yoilsho	5297	17	parameters	parameter	NNS
cord-006229-7yoilsho	5297	18	to	to	TO
cord-006229-7yoilsho	5297	19	predict	predict	VB
cord-006229-7yoilsho	5297	20	learning	learn	VBG
cord-006229-7yoilsho	5297	21	outcome	outcome	NN
cord-006229-7yoilsho	5297	22	and	and	CC
cord-006229-7yoilsho	5297	23	exam	exam	NN
cord-006229-7yoilsho	5297	24	performance	performance	NN
cord-006229-7yoilsho	5297	25	.	.	.
cord-006229-7yoilsho	5298	1	Total	total	JJ
cord-006229-7yoilsho	5298	2	score	score	NN
cord-006229-7yoilsho	5298	3	and	and	CC
cord-006229-7yoilsho	5298	4	score	score	NN
cord-006229-7yoilsho	5298	5	of	of	IN
cord-006229-7yoilsho	5298	6	the	the	DT
cord-006229-7yoilsho	5298	7	first	first	JJ
cord-006229-7yoilsho	5298	8	attempt	attempt	NN
cord-006229-7yoilsho	5298	9	were	be	VBD
cord-006229-7yoilsho	5298	10	identified	identify	VBN
cord-006229-7yoilsho	5298	11	as	as	IN
cord-006229-7yoilsho	5298	12	parameters	parameter	NNS
cord-006229-7yoilsho	5298	13	with	with	IN
cord-006229-7yoilsho	5298	14	the	the	DT
cord-006229-7yoilsho	5298	15	highest	high	JJS
cord-006229-7yoilsho	5298	16	predictive	predictive	JJ
cord-006229-7yoilsho	5298	17	power	power	NN
cord-006229-7yoilsho	5298	18	.	.	.
cord-006229-7yoilsho	5299	1	In	in	IN
cord-006229-7yoilsho	5299	2	conclusion	conclusion	NN
cord-006229-7yoilsho	5299	3	,	,	,
cord-006229-7yoilsho	5299	4	our	-PRON-	PRP$
cord-006229-7yoilsho	5299	5	study	study	NN
cord-006229-7yoilsho	5299	6	underscores	underscore	VBZ
cord-006229-7yoilsho	5299	7	the	the	DT
cord-006229-7yoilsho	5299	8	potential	potential	NN
cord-006229-7yoilsho	5299	9	of	of	IN
cord-006229-7yoilsho	5299	10	learning	learn	VBG
cord-006229-7yoilsho	5299	11	analytics	analytic	NNS
cord-006229-7yoilsho	5299	12	as	as	IN
cord-006229-7yoilsho	5299	13	valuable	valuable	JJ
cord-006229-7yoilsho	5299	14	feedback	feedback	NN
cord-006229-7yoilsho	5299	15	source	source	NN
cord-006229-7yoilsho	5299	16	in	in	IN
cord-006229-7yoilsho	5299	17	undergraduate	undergraduate	JJ
cord-006229-7yoilsho	5299	18	medical	medical	JJ
cord-006229-7yoilsho	5299	19	education	education	NN
cord-006229-7yoilsho	5299	20	of	of	IN
cord-006229-7yoilsho	5299	21	pharmacology	pharmacology	NN
cord-006229-7yoilsho	5299	22	.	.	.
cord-006229-7yoilsho	5300	1	In	in	IN
cord-006229-7yoilsho	5300	2	educational	educational	JJ
cord-006229-7yoilsho	5300	3	settings	setting	NNS
cord-006229-7yoilsho	5300	4	,	,	,
cord-006229-7yoilsho	5300	5	tests	test	NNS
cord-006229-7yoilsho	5300	6	(	(	-LRB-
cord-006229-7yoilsho	5300	7	e.g.	e.g.	RB
cord-006229-7yoilsho	5300	8	,	,	,
cord-006229-7yoilsho	5300	9	written	write	VBN
cord-006229-7yoilsho	5300	10	or	or	CC
cord-006229-7yoilsho	5300	11	oral	oral	JJ
cord-006229-7yoilsho	5300	12	exams	exam	NNS
cord-006229-7yoilsho	5300	13	)	)	-RRB-
cord-006229-7yoilsho	5300	14	are	be	VBP
cord-006229-7yoilsho	5300	15	usually	usually	RB
cord-006229-7yoilsho	5300	16	considered	consider	VBN
cord-006229-7yoilsho	5300	17	devices	device	NNS
cord-006229-7yoilsho	5300	18	of	of	IN
cord-006229-7yoilsho	5300	19	assessment	assessment	NN
cord-006229-7yoilsho	5300	20	.	.	.
cord-006229-7yoilsho	5301	1	However	however	RB
cord-006229-7yoilsho	5301	2	,	,	,
cord-006229-7yoilsho	5301	3	a	a	DT
cord-006229-7yoilsho	5301	4	recent	recent	JJ
cord-006229-7yoilsho	5301	5	and	and	CC
cord-006229-7yoilsho	5301	6	intriguing	intriguing	JJ
cord-006229-7yoilsho	5301	7	line	line	NN
cord-006229-7yoilsho	5301	8	of	of	IN
cord-006229-7yoilsho	5301	9	evidence	evidence	NN
cord-006229-7yoilsho	5301	10	from	from	IN
cord-006229-7yoilsho	5301	11	basic	basic	JJ
cord-006229-7yoilsho	5301	12	cognitive	cognitive	JJ
cord-006229-7yoilsho	5301	13	psychological	psychological	JJ
cord-006229-7yoilsho	5301	14	research	research	NN
cord-006229-7yoilsho	5301	15	suggests	suggest	VBZ
cord-006229-7yoilsho	5301	16	that	that	IN
cord-006229-7yoilsho	5301	17	tests	test	NNS
cord-006229-7yoilsho	5301	18	may	may	MD
cord-006229-7yoilsho	5301	19	not	not	RB
cord-006229-7yoilsho	5301	20	only	only	RB
cord-006229-7yoilsho	5301	21	help	help	VB
cord-006229-7yoilsho	5301	22	to	to	TO
cord-006229-7yoilsho	5301	23	assess	assess	VB
cord-006229-7yoilsho	5301	24	what	what	WP
cord-006229-7yoilsho	5301	25	students	student	NNS
cord-006229-7yoilsho	5301	26	know	know	VBP
cord-006229-7yoilsho	5301	27	,	,	,
cord-006229-7yoilsho	5301	28	but	but	CC
cord-006229-7yoilsho	5301	29	may	may	MD
cord-006229-7yoilsho	5301	30	also	also	RB
cord-006229-7yoilsho	5301	31	help	help	VB
cord-006229-7yoilsho	5301	32	to	to	TO
cord-006229-7yoilsho	5301	33	improve	improve	VB
cord-006229-7yoilsho	5301	34	the	the	DT
cord-006229-7yoilsho	5301	35	learning	learning	NN
cord-006229-7yoilsho	5301	36	and	and	CC
cord-006229-7yoilsho	5301	37	long	long	JJ
cord-006229-7yoilsho	5301	38	-	-	HYPH
cord-006229-7yoilsho	5301	39	term	term	NN
cord-006229-7yoilsho	5301	40	retention	retention	NN
cord-006229-7yoilsho	5301	41	of	of	IN
cord-006229-7yoilsho	5301	42	information	information	NN
cord-006229-7yoilsho	5301	43	.	.	.
cord-006229-7yoilsho	5302	1	The	the	DT
cord-006229-7yoilsho	5302	2	goal	goal	NN
cord-006229-7yoilsho	5302	3	of	of	IN
cord-006229-7yoilsho	5302	4	the	the	DT
cord-006229-7yoilsho	5302	5	present	present	JJ
cord-006229-7yoilsho	5302	6	study	study	NN
cord-006229-7yoilsho	5302	7	was	be	VBD
cord-006229-7yoilsho	5302	8	to	to	TO
cord-006229-7yoilsho	5302	9	apply	apply	VB
cord-006229-7yoilsho	5302	10	such	such	JJ
cord-006229-7yoilsho	5302	11	test	test	NN
cord-006229-7yoilsho	5302	12	-	-	HYPH
cord-006229-7yoilsho	5302	13	enhanced	enhance	VBN
cord-006229-7yoilsho	5302	14	learning	learning	NN
cord-006229-7yoilsho	5302	15	to	to	IN
cord-006229-7yoilsho	5302	16	pharmacological	pharmacological	JJ
cord-006229-7yoilsho	5302	17	teaching	teaching	NN
cord-006229-7yoilsho	5302	18	.	.	.
cord-006229-7yoilsho	5303	1	After	after	IN
cord-006229-7yoilsho	5303	2	the	the	DT
cord-006229-7yoilsho	5303	3	last	last	JJ
cord-006229-7yoilsho	5303	4	lecture	lecture	NN
cord-006229-7yoilsho	5303	5	of	of	IN
cord-006229-7yoilsho	5303	6	a	a	DT
cord-006229-7yoilsho	5303	7	pharmacology	pharmacology	NN
cord-006229-7yoilsho	5303	8	class	class	NN
cord-006229-7yoilsho	5303	9	(	(	-LRB-
cord-006229-7yoilsho	5303	10	n=194	n=194	NNP
cord-006229-7yoilsho	5303	11	3	3	CD
cord-006229-7yoilsho	5303	12	rd	rd	NNP
cord-006229-7yoilsho	5303	13	-year	-year	JJ
cord-006229-7yoilsho	5303	14	medical	medical	JJ
cord-006229-7yoilsho	5303	15	students	student	NNS
cord-006229-7yoilsho	5303	16	,	,	,
cord-006229-7yoilsho	5303	17	n=213	n=213	NNP
cord-006229-7yoilsho	5303	18	4	4	CD
cord-006229-7yoilsho	5303	19	th	th	CD
cord-006229-7yoilsho	5303	20	-year	-year	JJ
cord-006229-7yoilsho	5303	21	medical	medical	JJ
cord-006229-7yoilsho	5303	22	students	student	NNS
cord-006229-7yoilsho	5303	23	:	:	:
cord-006229-7yoilsho	5303	24	basic	basic	JJ
cord-006229-7yoilsho	5303	25	or	or	CC
cord-006229-7yoilsho	5303	26	clinical	clinical	JJ
cord-006229-7yoilsho	5303	27	pharmacology	pharmacology	NN
cord-006229-7yoilsho	5303	28	,	,	,
cord-006229-7yoilsho	5303	29	respectively	respectively	RB
cord-006229-7yoilsho	5303	30	)	)	-RRB-
cord-006229-7yoilsho	5303	31	,	,	,
cord-006229-7yoilsho	5303	32	one	one	CD
cord-006229-7yoilsho	5303	33	week	week	NN
cord-006229-7yoilsho	5303	34	prior	prior	RB
cord-006229-7yoilsho	5303	35	to	to	IN
cord-006229-7yoilsho	5303	36	the	the	DT
cord-006229-7yoilsho	5303	37	final	final	JJ
cord-006229-7yoilsho	5303	38	exam	exam	NN
cord-006229-7yoilsho	5303	39	,	,	,
cord-006229-7yoilsho	5303	40	students	student	NNS
cord-006229-7yoilsho	5303	41	were	be	VBD
cord-006229-7yoilsho	5303	42	given	give	VBN
cord-006229-7yoilsho	5303	43	the	the	DT
cord-006229-7yoilsho	5303	44	opportunity	opportunity	NN
cord-006229-7yoilsho	5303	45	to	to	TO
cord-006229-7yoilsho	5303	46	voluntarily	voluntarily	RB
cord-006229-7yoilsho	5303	47	participate	participate	VB
cord-006229-7yoilsho	5303	48	in	in	IN
cord-006229-7yoilsho	5303	49	online	online	JJ
cord-006229-7yoilsho	5303	50	exam	exam	NN
cord-006229-7yoilsho	5303	51	.	.	.
cord-006229-7yoilsho	5304	1	Because	because	IN
cord-006229-7yoilsho	5304	2	pilot	pilot	NN
cord-006229-7yoilsho	5304	3	work	work	NN
cord-006229-7yoilsho	5304	4	from	from	IN
cord-006229-7yoilsho	5304	5	previous	previous	JJ
cord-006229-7yoilsho	5304	6	semesters	semester	NNS
cord-006229-7yoilsho	5304	7	had	have	VBD
cord-006229-7yoilsho	5304	8	revealed	reveal	VBN
cord-006229-7yoilsho	5304	9	relatively	relatively	RB
cord-006229-7yoilsho	5304	10	low	low	JJ
cord-006229-7yoilsho	5304	11	levels	level	NNS
cord-006229-7yoilsho	5304	12	of	of	IN
cord-006229-7yoilsho	5304	13	participation	participation	NN
cord-006229-7yoilsho	5304	14	in	in	IN
cord-006229-7yoilsho	5304	15	such	such	JJ
cord-006229-7yoilsho	5304	16	formative	formative	JJ
cord-006229-7yoilsho	5304	17	exams	exam	NNS
cord-006229-7yoilsho	5304	18	,	,	,
cord-006229-7yoilsho	5304	19	students	student	NNS
cord-006229-7yoilsho	5304	20	were	be	VBD
cord-006229-7yoilsho	5304	21	offered	offer	VBN
cord-006229-7yoilsho	5304	22	bonus	bonus	NN
cord-006229-7yoilsho	5304	23	points	point	NNS
cord-006229-7yoilsho	5304	24	for	for	IN
cord-006229-7yoilsho	5304	25	(	(	-LRB-
cord-006229-7yoilsho	5304	26	successful	successful	JJ
cord-006229-7yoilsho	5304	27	)	)	-RRB-
cord-006229-7yoilsho	5304	28	participation	participation	NN
cord-006229-7yoilsho	5304	29	as	as	IN
cord-006229-7yoilsho	5304	30	an	an	DT
cord-006229-7yoilsho	5304	31	incentive	incentive	NN
cord-006229-7yoilsho	5304	32	.	.	.
cord-006229-7yoilsho	5305	1	The	the	DT
cord-006229-7yoilsho	5305	2	online	online	JJ
cord-006229-7yoilsho	5305	3	exam	exam	NN
cord-006229-7yoilsho	5305	4	consisted	consist	VBD
cord-006229-7yoilsho	5305	5	of	of	IN
cord-006229-7yoilsho	5305	6	60	60	CD
cord-006229-7yoilsho	5305	7	items	item	NNS
cord-006229-7yoilsho	5305	8	(	(	-LRB-
cord-006229-7yoilsho	5305	9	i.e.	i.e.	FW
cord-006229-7yoilsho	5305	10	,	,	,
cord-006229-7yoilsho	5305	11	selected	select	VBN
cord-006229-7yoilsho	5305	12	pieces	piece	NNS
cord-006229-7yoilsho	5305	13	of	of	IN
cord-006229-7yoilsho	5305	14	information	information	NN
cord-006229-7yoilsho	5305	15	from	from	IN
cord-006229-7yoilsho	5305	16	the	the	DT
cord-006229-7yoilsho	5305	17	lectures	lecture	NNS
cord-006229-7yoilsho	5305	18	and	and	CC
cord-006229-7yoilsho	5305	19	seminars	seminar	NNS
cord-006229-7yoilsho	5305	20	)	)	-RRB-
cord-006229-7yoilsho	5305	21	and	and	CC
cord-006229-7yoilsho	5305	22	was	be	VBD
cord-006229-7yoilsho	5305	23	provided	provide	VBN
cord-006229-7yoilsho	5305	24	on	on	IN
cord-006229-7yoilsho	5305	25	the	the	DT
cord-006229-7yoilsho	5305	26	E	e	NN
cord-006229-7yoilsho	5305	27	-	-	HYPH
cord-006229-7yoilsho	5305	28	Learning	learning	JJ
cord-006229-7yoilsho	5305	29	platform	platform	NN
cord-006229-7yoilsho	5305	30	ILIAS	ILIAS	NNP
cord-006229-7yoilsho	5305	31	.	.	.
cord-006229-7yoilsho	5306	1	Twenty	twenty	CD
cord-006229-7yoilsho	5306	2	of	of	IN
cord-006229-7yoilsho	5306	3	the	the	DT
cord-006229-7yoilsho	5306	4	60	60	CD
cord-006229-7yoilsho	5306	5	items	item	NNS
cord-006229-7yoilsho	5306	6	were	be	VBD
cord-006229-7yoilsho	5306	7	presented	present	VBN
cord-006229-7yoilsho	5306	8	as	as	IN
cord-006229-7yoilsho	5306	9	statements	statement	NNS
cord-006229-7yoilsho	5306	10	for	for	IN
cord-006229-7yoilsho	5306	11	restudy	restudy	NN
cord-006229-7yoilsho	5306	12	,	,	,
cord-006229-7yoilsho	5306	13	20	20	CD
cord-006229-7yoilsho	5306	14	items	item	NNS
cord-006229-7yoilsho	5306	15	were	be	VBD
cord-006229-7yoilsho	5306	16	tested	test	VBN
cord-006229-7yoilsho	5306	17	using	use	VBG
cord-006229-7yoilsho	5306	18	single	single	JJ
cord-006229-7yoilsho	5306	19	-	-	HYPH
cord-006229-7yoilsho	5306	20	choice	choice	NN
cord-006229-7yoilsho	5306	21	questions	question	NNS
cord-006229-7yoilsho	5306	22	,	,	,
cord-006229-7yoilsho	5306	23	and	and	CC
cord-006229-7yoilsho	5306	24	20	20	CD
cord-006229-7yoilsho	5306	25	items	item	NNS
cord-006229-7yoilsho	5306	26	were	be	VBD
cord-006229-7yoilsho	5306	27	tested	test	VBN
cord-006229-7yoilsho	5306	28	using	use	VBG
cord-006229-7yoilsho	5306	29	short	short	JJ
cord-006229-7yoilsho	5306	30	-	-	HYPH
cord-006229-7yoilsho	5306	31	answer	answer	NN
cord-006229-7yoilsho	5306	32	questions	question	NNS
cord-006229-7yoilsho	5306	33	.	.	.
cord-006229-7yoilsho	5307	1	Randomly	randomly	RB
cord-006229-7yoilsho	5307	2	a	a	DT
cord-006229-7yoilsho	5307	3	third	third	NN
cord-006229-7yoilsho	5307	4	of	of	IN
cord-006229-7yoilsho	5307	5	the	the	DT
cord-006229-7yoilsho	5307	6	students	student	NNS
cord-006229-7yoilsho	5307	7	were	be	VBD
cord-006229-7yoilsho	5307	8	assigned	assign	VBN
cord-006229-7yoilsho	5307	9	to	to	IN
cord-006229-7yoilsho	5307	10	different	different	JJ
cord-006229-7yoilsho	5307	11	sets	set	NNS
cord-006229-7yoilsho	5307	12	of	of	IN
cord-006229-7yoilsho	5307	13	questions	question	NNS
cord-006229-7yoilsho	5307	14	.	.	.
cord-006229-7yoilsho	5308	1	The	the	DT
cord-006229-7yoilsho	5308	2	summative	summative	JJ
cord-006229-7yoilsho	5308	3	final	final	JJ
cord-006229-7yoilsho	5308	4	written	write	VBN
cord-006229-7yoilsho	5308	5	exam	exam	NN
cord-006229-7yoilsho	5308	6	for	for	IN
cord-006229-7yoilsho	5308	7	each	each	DT
cord-006229-7yoilsho	5308	8	group	group	NN
cord-006229-7yoilsho	5308	9	consisted	consist	VBD
cord-006229-7yoilsho	5308	10	of	of	IN
cord-006229-7yoilsho	5308	11	30	30	CD
cord-006229-7yoilsho	5308	12	single	single	JJ
cord-006229-7yoilsho	5308	13	-	-	HYPH
cord-006229-7yoilsho	5308	14	choice	choice	NN
cord-006229-7yoilsho	5308	15	questions	question	NNS
cord-006229-7yoilsho	5308	16	,	,	,
cord-006229-7yoilsho	5308	17	15	15	CD
cord-006229-7yoilsho	5308	18	questions	question	NNS
cord-006229-7yoilsho	5308	19	of	of	IN
cord-006229-7yoilsho	5308	20	which	which	WDT
cord-006229-7yoilsho	5308	21	had	have	VBD
cord-006229-7yoilsho	5308	22	not	not	RB
cord-006229-7yoilsho	5308	23	been	be	VBN
cord-006229-7yoilsho	5308	24	used	use	VBN
cord-006229-7yoilsho	5308	25	before	before	RB
cord-006229-7yoilsho	5308	26	(	(	-LRB-
cord-006229-7yoilsho	5308	27	as	as	IN
cord-006229-7yoilsho	5308	28	a	a	DT
cord-006229-7yoilsho	5308	29	standard	standard	NN
cord-006229-7yoilsho	5308	30	of	of	IN
cord-006229-7yoilsho	5308	31	comparison	comparison	NN
cord-006229-7yoilsho	5308	32	)	)	-RRB-
cord-006229-7yoilsho	5308	33	.	.	.
cord-006229-7yoilsho	5309	1	The	the	DT
cord-006229-7yoilsho	5309	2	remaining	remain	VBG
cord-006229-7yoilsho	5309	3	15	15	CD
cord-006229-7yoilsho	5309	4	questions	question	NNS
cord-006229-7yoilsho	5309	5	of	of	IN
cord-006229-7yoilsho	5309	6	the	the	DT
cord-006229-7yoilsho	5309	7	final	final	JJ
cord-006229-7yoilsho	5309	8	exam	exam	NN
cord-006229-7yoilsho	5309	9	were	be	VBD
cord-006229-7yoilsho	5309	10	taken	take	VBN
cord-006229-7yoilsho	5309	11	from	from	IN
cord-006229-7yoilsho	5309	12	the	the	DT
cord-006229-7yoilsho	5309	13	previous	previous	JJ
cord-006229-7yoilsho	5309	14	online	online	JJ
cord-006229-7yoilsho	5309	15	exam	exam	NN
cord-006229-7yoilsho	5309	16	,	,	,
cord-006229-7yoilsho	5309	17	but	but	CC
cord-006229-7yoilsho	5309	18	were	be	VBD
cord-006229-7yoilsho	5309	19	slightly	slightly	RB
cord-006229-7yoilsho	5309	20	reworded	reword	VBN
cord-006229-7yoilsho	5309	21	to	to	TO
cord-006229-7yoilsho	5309	22	avoid	avoid	VB
cord-006229-7yoilsho	5309	23	ceiling	ceiling	NN
cord-006229-7yoilsho	5309	24	effects	effect	NNS
cord-006229-7yoilsho	5309	25	.	.	.
cord-006229-7yoilsho	5310	1	Each	each	DT
cord-006229-7yoilsho	5310	2	of	of	IN
cord-006229-7yoilsho	5310	3	5	5	CD
cord-006229-7yoilsho	5310	4	of	of	IN
cord-006229-7yoilsho	5310	5	these	these	DT
cord-006229-7yoilsho	5310	6	reworded	reword	VBN
cord-006229-7yoilsho	5310	7	15	15	CD
cord-006229-7yoilsho	5310	8	questions	question	NNS
cord-006229-7yoilsho	5310	9	from	from	IN
cord-006229-7yoilsho	5310	10	the	the	DT
cord-006229-7yoilsho	5310	11	final	final	JJ
cord-006229-7yoilsho	5310	12	exam	exam	NN
cord-006229-7yoilsho	5310	13	corresponded	correspond	VBD
cord-006229-7yoilsho	5310	14	to	to	TO
cord-006229-7yoilsho	5310	15	restudy	restudy	VB
cord-006229-7yoilsho	5310	16	items	item	NNS
cord-006229-7yoilsho	5310	17	,	,	,
cord-006229-7yoilsho	5310	18	single	single	JJ
cord-006229-7yoilsho	5310	19	-	-	HYPH
cord-006229-7yoilsho	5310	20	choice	choice	NN
cord-006229-7yoilsho	5310	21	items	item	NNS
cord-006229-7yoilsho	5310	22	,	,	,
cord-006229-7yoilsho	5310	23	and	and	CC
cord-006229-7yoilsho	5310	24	short	short	JJ
cord-006229-7yoilsho	5310	25	-	-	HYPH
cord-006229-7yoilsho	5310	26	answer	answer	NN
cord-006229-7yoilsho	5310	27	items	item	NNS
cord-006229-7yoilsho	5310	28	from	from	IN
cord-006229-7yoilsho	5310	29	the	the	DT
cord-006229-7yoilsho	5310	30	online	online	JJ
cord-006229-7yoilsho	5310	31	exam	exam	NN
cord-006229-7yoilsho	5310	32	,	,	,
cord-006229-7yoilsho	5310	33	respectively	respectively	RB
cord-006229-7yoilsho	5310	34	.	.	.
cord-006229-7yoilsho	5311	1	The	the	DT
cord-006229-7yoilsho	5311	2	main	main	JJ
cord-006229-7yoilsho	5311	3	points	point	NNS
cord-006229-7yoilsho	5311	4	of	of	IN
cord-006229-7yoilsho	5311	5	interest	interest	NN
cord-006229-7yoilsho	5311	6	were	be	VBD
cord-006229-7yoilsho	5311	7	(	(	-LRB-
cord-006229-7yoilsho	5311	8	i	i	NN
cord-006229-7yoilsho	5311	9	)	)	-RRB-
cord-006229-7yoilsho	5311	10	whether	whether	IN
cord-006229-7yoilsho	5311	11	the	the	DT
cord-006229-7yoilsho	5311	12	re	re	NN
cord-006229-7yoilsho	5311	13	-	-	NN
cord-006229-7yoilsho	5311	14	processing	processing	NN
cord-006229-7yoilsho	5311	15	(	(	-LRB-
cord-006229-7yoilsho	5311	16	rewording	reword	VBG
cord-006229-7yoilsho	5311	17	and	and	CC
cord-006229-7yoilsho	5311	18	asking	ask	VBG
cord-006229-7yoilsho	5311	19	for	for	IN
cord-006229-7yoilsho	5311	20	transfer	transfer	NN
cord-006229-7yoilsho	5311	21	of	of	IN
cord-006229-7yoilsho	5311	22	knowledge	knowledge	NN
cord-006229-7yoilsho	5311	23	)	)	-RRB-
cord-006229-7yoilsho	5311	24	of	of	IN
cord-006229-7yoilsho	5311	25	information	information	NN
cord-006229-7yoilsho	5311	26	in	in	IN
cord-006229-7yoilsho	5311	27	the	the	DT
cord-006229-7yoilsho	5311	28	online	online	JJ
cord-006229-7yoilsho	5311	29	exam	exam	NN
cord-006229-7yoilsho	5311	30	affected	affect	VBN
cord-006229-7yoilsho	5311	31	participants	participant	NNS
cord-006229-7yoilsho	5311	32	'	'	POS
cord-006229-7yoilsho	5311	33	performance	performance	NN
cord-006229-7yoilsho	5311	34	on	on	IN
cord-006229-7yoilsho	5311	35	the	the	DT
cord-006229-7yoilsho	5311	36	final	final	JJ
cord-006229-7yoilsho	5311	37	exam	exam	NN
cord-006229-7yoilsho	5311	38	,	,	,
cord-006229-7yoilsho	5311	39	and	and	CC
cord-006229-7yoilsho	5311	40	(	(	-LRB-
cord-006229-7yoilsho	5311	41	ii	ii	NN
cord-006229-7yoilsho	5311	42	)	)	-RRB-
cord-006229-7yoilsho	5311	43	whether	whether	IN
cord-006229-7yoilsho	5311	44	any	any	DT
cord-006229-7yoilsho	5311	45	effect	effect	NN
cord-006229-7yoilsho	5311	46	depended	depend	VBD
cord-006229-7yoilsho	5311	47	on	on	IN
cord-006229-7yoilsho	5311	48	the	the	DT
cord-006229-7yoilsho	5311	49	specific	specific	JJ
cord-006229-7yoilsho	5311	50	type	type	NN
cord-006229-7yoilsho	5311	51	of	of	IN
cord-006229-7yoilsho	5311	52	re	re	NN
cord-006229-7yoilsho	5311	53	-	-	NN
cord-006229-7yoilsho	5311	54	processing	processing	JJ
cord-006229-7yoilsho	5311	55	(	(	-LRB-
cord-006229-7yoilsho	5311	56	restudy	restudy	VB
cord-006229-7yoilsho	5311	57	vs.	vs.	FW
cord-006229-7yoilsho	5311	58	single	single	JJ
cord-006229-7yoilsho	5311	59	-	-	HYPH
cord-006229-7yoilsho	5311	60	choice	choice	NN
cord-006229-7yoilsho	5311	61	test	test	NN
cord-006229-7yoilsho	5311	62	vs.	vs.	IN
cord-006229-7yoilsho	5311	63	shortanswer	shortanswer	NN
cord-006229-7yoilsho	5311	64	test	test	NN
cord-006229-7yoilsho	5311	65	)	)	-RRB-
cord-006229-7yoilsho	5311	66	.	.	.
cord-006229-7yoilsho	5312	1	If	if	IN
cord-006229-7yoilsho	5312	2	previous	previous	JJ
cord-006229-7yoilsho	5312	3	findings	finding	NNS
cord-006229-7yoilsho	5312	4	from	from	IN
cord-006229-7yoilsho	5312	5	basic	basic	JJ
cord-006229-7yoilsho	5312	6	cognitive	cognitive	JJ
cord-006229-7yoilsho	5312	7	psychological	psychological	JJ
cord-006229-7yoilsho	5312	8	research	research	NN
cord-006229-7yoilsho	5312	9	on	on	IN
cord-006229-7yoilsho	5312	10	testenhanced	testenhanced	JJ
cord-006229-7yoilsho	5312	11	learning	learning	NN
cord-006229-7yoilsho	5312	12	can	can	MD
cord-006229-7yoilsho	5312	13	be	be	VB
cord-006229-7yoilsho	5312	14	generalized	generalize	VBN
cord-006229-7yoilsho	5312	15	to	to	IN
cord-006229-7yoilsho	5312	16	more	more	RBR
cord-006229-7yoilsho	5312	17	applied	applied	JJ
cord-006229-7yoilsho	5312	18	settings	setting	NNS
cord-006229-7yoilsho	5312	19	and	and	CC
cord-006229-7yoilsho	5312	20	educationally	educationally	RB
cord-006229-7yoilsho	5312	21	more	more	RBR
cord-006229-7yoilsho	5312	22	relevant	relevant	JJ
cord-006229-7yoilsho	5312	23	materials	material	NNS
cord-006229-7yoilsho	5312	24	such	such	JJ
cord-006229-7yoilsho	5312	25	as	as	IN
cord-006229-7yoilsho	5312	26	pharmacological	pharmacological	JJ
cord-006229-7yoilsho	5312	27	information	information	NN
cord-006229-7yoilsho	5312	28	,	,	,
cord-006229-7yoilsho	5312	29	students	student	NNS
cord-006229-7yoilsho	5312	30	'	'	POS
cord-006229-7yoilsho	5312	31	performance	performance	NN
cord-006229-7yoilsho	5312	32	in	in	IN
cord-006229-7yoilsho	5312	33	the	the	DT
cord-006229-7yoilsho	5312	34	final	final	JJ
cord-006229-7yoilsho	5312	35	exam	exam	NN
cord-006229-7yoilsho	5312	36	should	should	MD
cord-006229-7yoilsho	5312	37	be	be	VB
cord-006229-7yoilsho	5312	38	better	well	JJR
cord-006229-7yoilsho	5312	39	for	for	IN
cord-006229-7yoilsho	5312	40	questions	question	NNS
cord-006229-7yoilsho	5312	41	corresponding	correspond	VBG
cord-006229-7yoilsho	5312	42	to	to	IN
cord-006229-7yoilsho	5312	43	previously	previously	RB
cord-006229-7yoilsho	5312	44	tested	test	VBN
cord-006229-7yoilsho	5312	45	items	item	NNS
cord-006229-7yoilsho	5312	46	than	than	IN
cord-006229-7yoilsho	5312	47	for	for	IN
cord-006229-7yoilsho	5312	48	questions	question	NNS
cord-006229-7yoilsho	5312	49	corresponding	correspond	VBG
cord-006229-7yoilsho	5312	50	to	to	IN
cord-006229-7yoilsho	5312	51	previously	previously	RB
cord-006229-7yoilsho	5312	52	restudied	restudie	VBN
cord-006229-7yoilsho	5312	53	items	item	NNS
cord-006229-7yoilsho	5312	54	.	.	.
cord-006229-7yoilsho	5313	1	Moreover	moreover	RB
cord-006229-7yoilsho	5313	2	,	,	,
cord-006229-7yoilsho	5313	3	if	if	IN
cord-006229-7yoilsho	5313	4	more	more	RBR
cord-006229-7yoilsho	5313	5	difficult	difficult	JJ
cord-006229-7yoilsho	5313	6	tests	test	NNS
cord-006229-7yoilsho	5313	7	lead	lead	VBP
cord-006229-7yoilsho	5313	8	to	to	IN
cord-006229-7yoilsho	5313	9	more	more	JJR
cord-006229-7yoilsho	5313	10	test	test	NN
cord-006229-7yoilsho	5313	11	-	-	HYPH
cord-006229-7yoilsho	5313	12	enhanced	enhance	VBN
cord-006229-7yoilsho	5313	13	learning	learning	NN
cord-006229-7yoilsho	5313	14	than	than	IN
cord-006229-7yoilsho	5313	15	less	less	RBR
cord-006229-7yoilsho	5313	16	difficult	difficult	JJ
cord-006229-7yoilsho	5313	17	tests	test	NNS
cord-006229-7yoilsho	5313	18	,	,	,
cord-006229-7yoilsho	5313	19	as	as	IN
cord-006229-7yoilsho	5313	20	is	be	VBZ
cord-006229-7yoilsho	5313	21	suggested	suggest	VBN
cord-006229-7yoilsho	5313	22	by	by	IN
cord-006229-7yoilsho	5313	23	recent	recent	JJ
cord-006229-7yoilsho	5313	24	findings	finding	NNS
cord-006229-7yoilsho	5313	25	from	from	IN
cord-006229-7yoilsho	5313	26	cognitive	cognitive	JJ
cord-006229-7yoilsho	5313	27	psychological	psychological	JJ
cord-006229-7yoilsho	5313	28	research	research	NN
cord-006229-7yoilsho	5313	29	,	,	,
cord-006229-7yoilsho	5313	30	performance	performance	NN
cord-006229-7yoilsho	5313	31	for	for	IN
cord-006229-7yoilsho	5313	32	questions	question	NNS
cord-006229-7yoilsho	5313	33	corresponding	correspond	VBG
cord-006229-7yoilsho	5313	34	to	to	IN
cord-006229-7yoilsho	5313	35	(	(	-LRB-
cord-006229-7yoilsho	5313	36	supposedly	supposedly	RB
cord-006229-7yoilsho	5313	37	more	more	RBR
cord-006229-7yoilsho	5313	38	difficult	difficult	JJ
cord-006229-7yoilsho	5313	39	)	)	-RRB-
cord-006229-7yoilsho	5313	40	short	short	JJ
cord-006229-7yoilsho	5313	41	-	-	HYPH
cord-006229-7yoilsho	5313	42	answer	answer	NN
cord-006229-7yoilsho	5313	43	items	item	NNS
cord-006229-7yoilsho	5313	44	should	should	MD
cord-006229-7yoilsho	5313	45	even	even	RB
cord-006229-7yoilsho	5313	46	exceed	exceed	VB
cord-006229-7yoilsho	5313	47	that	that	DT
cord-006229-7yoilsho	5313	48	for	for	IN
cord-006229-7yoilsho	5313	49	questions	question	NNS
cord-006229-7yoilsho	5313	50	corresponding	correspond	VBG
cord-006229-7yoilsho	5313	51	to	to	IN
cord-006229-7yoilsho	5313	52	(	(	-LRB-
cord-006229-7yoilsho	5313	53	supposedly	supposedly	RB
cord-006229-7yoilsho	5313	54	less	less	RBR
cord-006229-7yoilsho	5313	55	difficult	difficult	JJ
cord-006229-7yoilsho	5313	56	)	)	-RRB-
cord-006229-7yoilsho	5313	57	single	single	JJ
cord-006229-7yoilsho	5313	58	-	-	HYPH
cord-006229-7yoilsho	5313	59	choice	choice	NN
cord-006229-7yoilsho	5313	60	items	item	NNS
cord-006229-7yoilsho	5313	61	.	.	.
cord-006229-7yoilsho	5314	1	The	the	DT
cord-006229-7yoilsho	5314	2	present	present	JJ
cord-006229-7yoilsho	5314	3	findings	finding	NNS
cord-006229-7yoilsho	5314	4	bear	bear	VBP
cord-006229-7yoilsho	5314	5	direct	direct	JJ
cord-006229-7yoilsho	5314	6	implications	implication	NNS
cord-006229-7yoilsho	5314	7	for	for	IN
cord-006229-7yoilsho	5314	8	educational	educational	JJ
cord-006229-7yoilsho	5314	9	practice	practice	NN
cord-006229-7yoilsho	5314	10	.	.	.
cord-006229-7yoilsho	5315	1	Safe	safe	JJ
cord-006229-7yoilsho	5315	2	and	and	CC
cord-006229-7yoilsho	5315	3	rational	rational	JJ
cord-006229-7yoilsho	5315	4	prescribing	prescribing	NN
cord-006229-7yoilsho	5315	5	is	be	VBZ
cord-006229-7yoilsho	5315	6	one	one	CD
cord-006229-7yoilsho	5315	7	of	of	IN
cord-006229-7yoilsho	5315	8	future	future	JJ
cord-006229-7yoilsho	5315	9	physicians	physician	NNS
cord-006229-7yoilsho	5315	10	'	'	POS
cord-006229-7yoilsho	5315	11	key	key	JJ
cord-006229-7yoilsho	5315	12	skills	skill	NNS
cord-006229-7yoilsho	5315	13	[	[	-LRB-
cord-006229-7yoilsho	5315	14	1	1	CD
cord-006229-7yoilsho	5315	15	]	]	-RRB-
cord-006229-7yoilsho	5315	16	.	.	.
cord-006229-7yoilsho	5316	1	In	in	IN
cord-006229-7yoilsho	5316	2	order	order	NN
cord-006229-7yoilsho	5316	3	to	to	TO
cord-006229-7yoilsho	5316	4	address	address	VB
cord-006229-7yoilsho	5316	5	the	the	DT
cord-006229-7yoilsho	5316	6	persisting	persist	VBG
cord-006229-7yoilsho	5316	7	prescribing	prescribe	VBG
cord-006229-7yoilsho	5316	8	deficiencies	deficiency	NNS
cord-006229-7yoilsho	5316	9	[	[	-LRB-
cord-006229-7yoilsho	5316	10	2	2	CD
cord-006229-7yoilsho	5316	11	]	]	-RRB-
cord-006229-7yoilsho	5316	12	,	,	,
cord-006229-7yoilsho	5316	13	we	-PRON-	PRP
cord-006229-7yoilsho	5316	14	set	set	VBD
cord-006229-7yoilsho	5316	15	out	out	RP
cord-006229-7yoilsho	5316	16	to	to	TO
cord-006229-7yoilsho	5316	17	develop	develop	VB
cord-006229-7yoilsho	5316	18	a	a	DT
cord-006229-7yoilsho	5316	19	learning	learning	NN
cord-006229-7yoilsho	5316	20	tool	tool	NN
cord-006229-7yoilsho	5316	21	for	for	IN
cord-006229-7yoilsho	5316	22	pharmacotherapies	pharmacotherapie	NNS
cord-006229-7yoilsho	5316	23	of	of	IN
cord-006229-7yoilsho	5316	24	the	the	DT
cord-006229-7yoilsho	5316	25	most	most	RBS
cord-006229-7yoilsho	5316	26	important	important	JJ
cord-006229-7yoilsho	5316	27	diseases	disease	NNS
cord-006229-7yoilsho	5316	28	worldwide	worldwide	RB
cord-006229-7yoilsho	5316	29	.	.	.
cord-006229-7yoilsho	5317	1	The	the	DT
cord-006229-7yoilsho	5317	2	format	format	NN
cord-006229-7yoilsho	5317	3	,	,	,
cord-006229-7yoilsho	5317	4	scope	scope	NN
cord-006229-7yoilsho	5317	5	,	,	,
cord-006229-7yoilsho	5317	6	information	information	NN
cord-006229-7yoilsho	5317	7	architecture	architecture	NN
cord-006229-7yoilsho	5317	8	,	,	,
cord-006229-7yoilsho	5317	9	and	and	CC
cord-006229-7yoilsho	5317	10	functionalities	functionality	NNS
cord-006229-7yoilsho	5317	11	of	of	IN
cord-006229-7yoilsho	5317	12	the	the	DT
cord-006229-7yoilsho	5317	13	app	app	NN
cord-006229-7yoilsho	5317	14	were	be	VBD
cord-006229-7yoilsho	5317	15	identified	identify	VBN
cord-006229-7yoilsho	5317	16	through	through	IN
cord-006229-7yoilsho	5317	17	assessment	assessment	NN
cord-006229-7yoilsho	5317	18	of	of	IN
cord-006229-7yoilsho	5317	19	existing	exist	VBG
cord-006229-7yoilsho	5317	20	apps	app	NNS
cord-006229-7yoilsho	5317	21	,	,	,
cord-006229-7yoilsho	5317	22	literature	literature	NN
cord-006229-7yoilsho	5317	23	analysis	analysis	NN
cord-006229-7yoilsho	5317	24	,	,	,
cord-006229-7yoilsho	5317	25	app	app	VBZ
cord-006229-7yoilsho	5317	26	simulation	simulation	NN
cord-006229-7yoilsho	5317	27	-	-	HYPH
cord-006229-7yoilsho	5317	28	based	base	VBN
cord-006229-7yoilsho	5317	29	student	student	NN
cord-006229-7yoilsho	5317	30	surveys	survey	NNS
cord-006229-7yoilsho	5317	31	,	,	,
cord-006229-7yoilsho	5317	32	and	and	CC
cord-006229-7yoilsho	5317	33	expert	expert	JJ
cord-006229-7yoilsho	5317	34	advice	advice	NN
cord-006229-7yoilsho	5317	35	.	.	.
cord-006229-7yoilsho	5318	1	A	a	DT
cord-006229-7yoilsho	5318	2	fully	fully	RB
cord-006229-7yoilsho	5318	3	functional	functional	JJ
cord-006229-7yoilsho	5318	4	offline	offline	JJ
cord-006229-7yoilsho	5318	5	app	app	NN
cord-006229-7yoilsho	5318	6	format	format	NN
cord-006229-7yoilsho	5318	7	for	for	IN
cord-006229-7yoilsho	5318	8	smartphones	smartphone	NNS
cord-006229-7yoilsho	5318	9	was	be	VBD
cord-006229-7yoilsho	5318	10	selected	select	VBN
cord-006229-7yoilsho	5318	11	based	base	VBN
cord-006229-7yoilsho	5318	12	on	on	IN
cord-006229-7yoilsho	5318	13	the	the	DT
cord-006229-7yoilsho	5318	14	trends	trend	NNS
cord-006229-7yoilsho	5318	15	in	in	IN
cord-006229-7yoilsho	5318	16	using	use	VBG
cord-006229-7yoilsho	5318	17	digital	digital	JJ
cord-006229-7yoilsho	5318	18	technologies	technology	NNS
cord-006229-7yoilsho	5318	19	for	for	IN
cord-006229-7yoilsho	5318	20	educational	educational	JJ
cord-006229-7yoilsho	5318	21	purposes	purpose	NNS
cord-006229-7yoilsho	5318	22	[	[	-LRB-
cord-006229-7yoilsho	5318	23	3	3	CD
cord-006229-7yoilsho	5318	24	]	]	-RRB-
cord-006229-7yoilsho	5318	25	and	and	CC
cord-006229-7yoilsho	5318	26	on	on	IN
cord-006229-7yoilsho	5318	27	the	the	DT
cord-006229-7yoilsho	5318	28	unreliable	unreliable	JJ
cord-006229-7yoilsho	5318	29	internet	internet	NN
cord-006229-7yoilsho	5318	30	and	and	CC
cord-006229-7yoilsho	5318	31	power	power	NN
cord-006229-7yoilsho	5318	32	availability	availability	NN
cord-006229-7yoilsho	5318	33	in	in	IN
cord-006229-7yoilsho	5318	34	many	many	JJ
cord-006229-7yoilsho	5318	35	learning	learning	NN
cord-006229-7yoilsho	5318	36	settings	setting	NNS
cord-006229-7yoilsho	5318	37	.	.	.
cord-006229-7yoilsho	5319	1	A	a	DT
cord-006229-7yoilsho	5319	2	relational	relational	JJ
cord-006229-7yoilsho	5319	3	database	database	NN
cord-006229-7yoilsho	5319	4	based	base	VBN
cord-006229-7yoilsho	5319	5	on	on	IN
cord-006229-7yoilsho	5319	6	semantic	semantic	JJ
cord-006229-7yoilsho	5319	7	relationships	relationship	NNS
cord-006229-7yoilsho	5319	8	was	be	VBD
cord-006229-7yoilsho	5319	9	chosen	choose	VBN
cord-006229-7yoilsho	5319	10	to	to	TO
cord-006229-7yoilsho	5319	11	minimize	minimize	VB
cord-006229-7yoilsho	5319	12	information	information	NN
cord-006229-7yoilsho	5319	13	redundancy	redundancy	NN
cord-006229-7yoilsho	5319	14	and	and	CC
cord-006229-7yoilsho	5319	15	to	to	TO
cord-006229-7yoilsho	5319	16	enable	enable	VB
cord-006229-7yoilsho	5319	17	the	the	DT
cord-006229-7yoilsho	5319	18	retrieval	retrieval	NN
cord-006229-7yoilsho	5319	19	of	of	IN
cord-006229-7yoilsho	5319	20	drug	drug	NN
cord-006229-7yoilsho	5319	21	-	-	HYPH
cord-006229-7yoilsho	5319	22	related	relate	VBN
cord-006229-7yoilsho	5319	23	information	information	NN
cord-006229-7yoilsho	5319	24	in	in	IN
cord-006229-7yoilsho	5319	25	the	the	DT
cord-006229-7yoilsho	5319	26	context	context	NN
cord-006229-7yoilsho	5319	27	of	of	IN
cord-006229-7yoilsho	5319	28	mechanisms	mechanism	NNS
cord-006229-7yoilsho	5319	29	,	,	,
cord-006229-7yoilsho	5319	30	contra	contra	NNP
cord-006229-7yoilsho	5319	31	-	-	HYPH
cord-006229-7yoilsho	5319	32	and	and	CC
cord-006229-7yoilsho	5319	33	indications	indication	NNS
cord-006229-7yoilsho	5319	34	,	,	,
cord-006229-7yoilsho	5319	35	adverse	adverse	JJ
cord-006229-7yoilsho	5319	36	drug	drug	NN
cord-006229-7yoilsho	5319	37	reactions	reaction	NNS
cord-006229-7yoilsho	5319	38	,	,	,
cord-006229-7yoilsho	5319	39	interactions	interaction	NNS
cord-006229-7yoilsho	5319	40	,	,	,
cord-006229-7yoilsho	5319	41	and	and	CC
cord-006229-7yoilsho	5319	42	common	common	JJ
cord-006229-7yoilsho	5319	43	prescribing	prescribing	NN
cord-006229-7yoilsho	5319	44	situations	situation	NNS
cord-006229-7yoilsho	5319	45	.	.	.
cord-006229-7yoilsho	5320	1	The	the	DT
cord-006229-7yoilsho	5320	2	usability	usability	NN
cord-006229-7yoilsho	5320	3	was	be	VBD
cord-006229-7yoilsho	5320	4	optimized	optimize	VBN
cord-006229-7yoilsho	5320	5	using	use	VBG
cord-006229-7yoilsho	5320	6	a	a	DT
cord-006229-7yoilsho	5320	7	simulation	simulation	NN
cord-006229-7yoilsho	5320	8	of	of	IN
cord-006229-7yoilsho	5320	9	the	the	DT
cord-006229-7yoilsho	5320	10	app	app	NN
cord-006229-7yoilsho	5320	11	evaluated	evaluate	VBN
cord-006229-7yoilsho	5320	12	by	by	IN
cord-006229-7yoilsho	5320	13	medical	medical	JJ
cord-006229-7yoilsho	5320	14	students	student	NNS
cord-006229-7yoilsho	5320	15	from	from	IN
cord-006229-7yoilsho	5320	16	Germany	Germany	NNP
cord-006229-7yoilsho	5320	17	and	and	CC
cord-006229-7yoilsho	5320	18	Tanzania	Tanzania	NNP
cord-006229-7yoilsho	5320	19	,	,	,
cord-006229-7yoilsho	5320	20	and	and	CC
cord-006229-7yoilsho	5320	21	by	by	IN
cord-006229-7yoilsho	5320	22	experts	expert	NNS
cord-006229-7yoilsho	5320	23	.	.	.
cord-006229-7yoilsho	5321	1	A	a	DT
cord-006229-7yoilsho	5321	2	list	list	NN
cord-006229-7yoilsho	5321	3	of	of	IN
cord-006229-7yoilsho	5321	4	67	67	CD
cord-006229-7yoilsho	5321	5	indications	indication	NNS
cord-006229-7yoilsho	5321	6	was	be	VBD
cord-006229-7yoilsho	5321	7	assembled	assemble	VBN
cord-006229-7yoilsho	5321	8	beginning	begin	VBG
cord-006229-7yoilsho	5321	9	with	with	IN
cord-006229-7yoilsho	5321	10	disease	disease	NN
cord-006229-7yoilsho	5321	11	burden	burden	NNP
cord-006229-7yoilsho	5321	12	data	datum	NNS
cord-006229-7yoilsho	5321	13	for	for	IN
cord-006229-7yoilsho	5321	14	the	the	DT
cord-006229-7yoilsho	5321	15	seven	seven	CD
cord-006229-7yoilsho	5321	16	WHO	who	WP
cord-006229-7yoilsho	5321	17	World	World	NNP
cord-006229-7yoilsho	5321	18	Bank	Bank	NNP
cord-006229-7yoilsho	5321	19	regions	region	NNS
cord-006229-7yoilsho	5321	20	.	.	.
cord-006229-7yoilsho	5322	1	Each	each	DT
cord-006229-7yoilsho	5322	2	disease	disease	NN
cord-006229-7yoilsho	5322	3	accounts	account	VBZ
cord-006229-7yoilsho	5322	4	for	for	IN
cord-006229-7yoilsho	5322	5	at	at	RB
cord-006229-7yoilsho	5322	6	least	least	RBS
cord-006229-7yoilsho	5322	7	0.3	0.3	CD
cord-006229-7yoilsho	5322	8	%	%	NN
cord-006229-7yoilsho	5322	9	of	of	IN
cord-006229-7yoilsho	5322	10	life	life	NN
cord-006229-7yoilsho	5322	11	years	year	NNS
cord-006229-7yoilsho	5322	12	lost	lose	VBN
cord-006229-7yoilsho	5322	13	due	due	IN
cord-006229-7yoilsho	5322	14	to	to	IN
cord-006229-7yoilsho	5322	15	premature	premature	JJ
cord-006229-7yoilsho	5322	16	death	death	NN
cord-006229-7yoilsho	5322	17	or	or	CC
cord-006229-7yoilsho	5322	18	lived	live	VBD
cord-006229-7yoilsho	5322	19	with	with	IN
cord-006229-7yoilsho	5322	20	ill	ill	JJ
cord-006229-7yoilsho	5322	21	-	-	HYPH
cord-006229-7yoilsho	5322	22	health	health	NN
cord-006229-7yoilsho	5322	23	or	or	CC
cord-006229-7yoilsho	5322	24	disability	disability	NN
cord-006229-7yoilsho	5322	25	(	(	-LRB-
cord-006229-7yoilsho	5322	26	DALY	DALY	NNP
cord-006229-7yoilsho	5322	27	)	)	-RRB-
cord-006229-7yoilsho	5322	28	in	in	IN
cord-006229-7yoilsho	5322	29	at	at	RB
cord-006229-7yoilsho	5322	30	least	least	RBS
cord-006229-7yoilsho	5322	31	one	one	CD
cord-006229-7yoilsho	5322	32	region	region	NN
cord-006229-7yoilsho	5322	33	.	.	.
cord-006229-7yoilsho	5323	1	The	the	DT
cord-006229-7yoilsho	5323	2	list	list	NN
cord-006229-7yoilsho	5323	3	was	be	VBD
cord-006229-7yoilsho	5323	4	further	further	RB
cord-006229-7yoilsho	5323	5	complemented	complement	VBN
cord-006229-7yoilsho	5323	6	according	accord	VBG
cord-006229-7yoilsho	5323	7	to	to	IN
cord-006229-7yoilsho	5323	8	expert	expert	NN
cord-006229-7yoilsho	5323	9	recommendations	recommendation	NNS
cord-006229-7yoilsho	5323	10	.	.	.
cord-006229-7yoilsho	5324	1	Therapeutic	therapeutic	JJ
cord-006229-7yoilsho	5324	2	recommendations	recommendation	NNS
cord-006229-7yoilsho	5324	3	are	be	VBP
cord-006229-7yoilsho	5324	4	based	base	VBN
cord-006229-7yoilsho	5324	5	on	on	IN
cord-006229-7yoilsho	5324	6	current	current	JJ
cord-006229-7yoilsho	5324	7	guidelines	guideline	NNS
cord-006229-7yoilsho	5324	8	,	,	,
cord-006229-7yoilsho	5324	9	considering	consider	VBG
cord-006229-7yoilsho	5324	10	cheaper	cheap	JJR
cord-006229-7yoilsho	5324	11	treatment	treatment	NN
cord-006229-7yoilsho	5324	12	alternatives	alternative	NNS
cord-006229-7yoilsho	5324	13	provided	provide	VBN
cord-006229-7yoilsho	5324	14	in	in	IN
cord-006229-7yoilsho	5324	15	the	the	DT
cord-006229-7yoilsho	5324	16	WHO	WHO	NNP
cord-006229-7yoilsho	5324	17	List	List	NNP
cord-006229-7yoilsho	5324	18	of	of	IN
cord-006229-7yoilsho	5324	19	Essential	Essential	NNP
cord-006229-7yoilsho	5324	20	Medicines	Medicines	NNPS
cord-006229-7yoilsho	5324	21	.	.	.
cord-006229-7yoilsho	5325	1	A	a	DT
cord-006229-7yoilsho	5325	2	novel	novel	JJ
cord-006229-7yoilsho	5325	3	dual	dual	JJ
cord-006229-7yoilsho	5325	4	-	-	HYPH
cord-006229-7yoilsho	5325	5	scale	scale	NN
cord-006229-7yoilsho	5325	6	classification	classification	NN
cord-006229-7yoilsho	5325	7	system	system	NN
cord-006229-7yoilsho	5325	8	lists	list	VBZ
cord-006229-7yoilsho	5325	9	drug	drug	NN
cord-006229-7yoilsho	5325	10	mechanisms	mechanism	NNS
cord-006229-7yoilsho	5325	11	according	accord	VBG
cord-006229-7yoilsho	5325	12	to	to	IN
cord-006229-7yoilsho	5325	13	the	the	DT
cord-006229-7yoilsho	5325	14	affected	affected	JJ
cord-006229-7yoilsho	5325	15	physiological	physiological	JJ
cord-006229-7yoilsho	5325	16	process	process	NN
cord-006229-7yoilsho	5325	17	and	and	CC
cord-006229-7yoilsho	5325	18	to	to	IN
cord-006229-7yoilsho	5325	19	the	the	DT
cord-006229-7yoilsho	5325	20	resulting	result	VBG
cord-006229-7yoilsho	5325	21	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	5325	22	effect	effect	NN
cord-006229-7yoilsho	5325	23	[	[	-LRB-
cord-006229-7yoilsho	5325	24	4	4	CD
cord-006229-7yoilsho	5325	25	]	]	-RRB-
cord-006229-7yoilsho	5325	26	.	.	.
cord-006229-7yoilsho	5326	1	Contraindications	contraindication	NNS
cord-006229-7yoilsho	5326	2	,	,	,
cord-006229-7yoilsho	5326	3	adverse	adverse	JJ
cord-006229-7yoilsho	5326	4	drug	drug	NN
cord-006229-7yoilsho	5326	5	reactions	reaction	NNS
cord-006229-7yoilsho	5326	6	,	,	,
cord-006229-7yoilsho	5326	7	and	and	CC
cord-006229-7yoilsho	5326	8	interactions	interaction	NNS
cord-006229-7yoilsho	5326	9	were	be	VBD
cord-006229-7yoilsho	5326	10	compiled	compile	VBN
cord-006229-7yoilsho	5326	11	using	use	VBG
cord-006229-7yoilsho	5326	12	drug	drug	NN
cord-006229-7yoilsho	5326	13	monographs	monograph	NNS
cord-006229-7yoilsho	5326	14	of	of	IN
cord-006229-7yoilsho	5326	15	the	the	DT
cord-006229-7yoilsho	5326	16	European	European	NNP
cord-006229-7yoilsho	5326	17	Medical	Medical	NNP
cord-006229-7yoilsho	5326	18	Agency	Agency	NNP
cord-006229-7yoilsho	5326	19	,	,	,
cord-006229-7yoilsho	5326	20	the	the	DT
cord-006229-7yoilsho	5326	21	US	US	NNP
cord-006229-7yoilsho	5326	22	Food	Food	NNP
cord-006229-7yoilsho	5326	23	and	and	CC
cord-006229-7yoilsho	5326	24	Drug	Drug	NNP
cord-006229-7yoilsho	5326	25	Administration	Administration	NNP
cord-006229-7yoilsho	5326	26	,	,	,
cord-006229-7yoilsho	5326	27	and	and	CC
cord-006229-7yoilsho	5326	28	Health	Health	NNP
cord-006229-7yoilsho	5326	29	Canada	Canada	NNP
cord-006229-7yoilsho	5326	30	.	.	.
cord-006229-7yoilsho	5327	1	Unexpectedly	unexpectedly	RB
cord-006229-7yoilsho	5327	2	,	,	,
cord-006229-7yoilsho	5327	3	we	-PRON-	PRP
cord-006229-7yoilsho	5327	4	found	find	VBD
cord-006229-7yoilsho	5327	5	significant	significant	JJ
cord-006229-7yoilsho	5327	6	differences	difference	NNS
cord-006229-7yoilsho	5327	7	among	among	IN
cord-006229-7yoilsho	5327	8	these	these	DT
cord-006229-7yoilsho	5327	9	sources	source	NNS
cord-006229-7yoilsho	5327	10	in	in	IN
cord-006229-7yoilsho	5327	11	respect	respect	NN
cord-006229-7yoilsho	5327	12	of	of	IN
cord-006229-7yoilsho	5327	13	adverse	adverse	JJ
cord-006229-7yoilsho	5327	14	drug	drug	NN
cord-006229-7yoilsho	5327	15	reactions	reaction	NNS
cord-006229-7yoilsho	5327	16	.	.	.
cord-006229-7yoilsho	5328	1	This	this	DT
cord-006229-7yoilsho	5328	2	necessitated	necessitate	VBD
cord-006229-7yoilsho	5328	3	the	the	DT
cord-006229-7yoilsho	5328	4	ongoing	ongoing	JJ
cord-006229-7yoilsho	5328	5	verification	verification	NN
cord-006229-7yoilsho	5328	6	through	through	IN
cord-006229-7yoilsho	5328	7	surveying	survey	VBG
cord-006229-7yoilsho	5328	8	general	general	JJ
cord-006229-7yoilsho	5328	9	practitioners	practitioner	NNS
cord-006229-7yoilsho	5328	10	and	and	CC
cord-006229-7yoilsho	5328	11	specialists	specialist	NNS
cord-006229-7yoilsho	5328	12	in	in	IN
cord-006229-7yoilsho	5328	13	internal	internal	JJ
cord-006229-7yoilsho	5328	14	medicine	medicine	NN
cord-006229-7yoilsho	5328	15	.	.	.
cord-006229-7yoilsho	5329	1	During	during	IN
cord-006229-7yoilsho	5329	2	the	the	DT
cord-006229-7yoilsho	5329	3	DGPT	dgpt	NN
cord-006229-7yoilsho	5329	4	meeting	meeting	NN
cord-006229-7yoilsho	5329	5	we	-PRON-	PRP
cord-006229-7yoilsho	5329	6	will	will	MD
cord-006229-7yoilsho	5329	7	present	present	VB
cord-006229-7yoilsho	5329	8	the	the	DT
cord-006229-7yoilsho	5329	9	results	result	NNS
cord-006229-7yoilsho	5329	10	of	of	IN
cord-006229-7yoilsho	5329	11	testing	testing	NN
cord-006229-7yoilsho	5329	12	of	of	IN
cord-006229-7yoilsho	5329	13	the	the	DT
cord-006229-7yoilsho	5329	14	cardiovascular	cardiovascular	JJ
cord-006229-7yoilsho	5329	15	section	section	NN
cord-006229-7yoilsho	5329	16	comprising	comprise	VBG
cord-006229-7yoilsho	5329	17	8	8	CD
cord-006229-7yoilsho	5329	18	indications	indication	NNS
cord-006229-7yoilsho	5329	19	,	,	,
cord-006229-7yoilsho	5329	20	28	28	CD
cord-006229-7yoilsho	5329	21	drugs	drug	NNS
cord-006229-7yoilsho	5329	22	representing	represent	VBG
cord-006229-7yoilsho	5329	23	25	25	CD
cord-006229-7yoilsho	5329	24	mechanisms	mechanism	NNS
cord-006229-7yoilsho	5329	25	,	,	,
cord-006229-7yoilsho	5329	26	and	and	CC
cord-006229-7yoilsho	5329	27	up	up	IN
cord-006229-7yoilsho	5329	28	to	to	TO
cord-006229-7yoilsho	5329	29	120	120	CD
cord-006229-7yoilsho	5329	30	adverse	adverse	JJ
cord-006229-7yoilsho	5329	31	drug	drug	NN
cord-006229-7yoilsho	5329	32	reactions	reaction	NNS
cord-006229-7yoilsho	5329	33	.	.	.
cord-006229-7yoilsho	5330	1	The	the	DT
cord-006229-7yoilsho	5330	2	European	European	NNP
cord-006229-7yoilsho	5330	3	Certified	Certified	NNP
cord-006229-7yoilsho	5330	4	Pharmacologists	Pharmacologists	NNPS
cord-006229-7yoilsho	5330	5	(	(	-LRB-
cord-006229-7yoilsho	5330	6	EuCP	EuCP	NNP
cord-006229-7yoilsho	5330	7	)	)	-RRB-
cord-006229-7yoilsho	5330	8	Programme	Programme	NNP
cord-006229-7yoilsho	5330	9	was	be	VBD
cord-006229-7yoilsho	5330	10	lauched	lauche	VBN
cord-006229-7yoilsho	5330	11	in	in	IN
cord-006229-7yoilsho	5330	12	July	July	NNP
cord-006229-7yoilsho	5330	13	2014	2014	CD
cord-006229-7yoilsho	5330	14	by	by	IN
cord-006229-7yoilsho	5330	15	the	the	DT
cord-006229-7yoilsho	5330	16	Federation	Federation	NNP
cord-006229-7yoilsho	5330	17	of	of	IN
cord-006229-7yoilsho	5330	18	European	European	NNP
cord-006229-7yoilsho	5330	19	Pharmacological	Pharmacological	NNP
cord-006229-7yoilsho	5330	20	Societies	Societies	NNPS
cord-006229-7yoilsho	5330	21	with	with	IN
cord-006229-7yoilsho	5330	22	the	the	DT
cord-006229-7yoilsho	5330	23	intention	intention	NN
cord-006229-7yoilsho	5330	24	to	to	TO
cord-006229-7yoilsho	5330	25	identify	identify	VB
cord-006229-7yoilsho	5330	26	experts	expert	NNS
cord-006229-7yoilsho	5330	27	in	in	IN
cord-006229-7yoilsho	5330	28	the	the	DT
cord-006229-7yoilsho	5330	29	field	field	NN
cord-006229-7yoilsho	5330	30	of	of	IN
cord-006229-7yoilsho	5330	31	pharmacology	pharmacology	NN
cord-006229-7yoilsho	5330	32	whose	whose	WP$
cord-006229-7yoilsho	5330	33	competency	competency	NN
cord-006229-7yoilsho	5330	34	profile	profile	NN
cord-006229-7yoilsho	5330	35	,	,	,
cord-006229-7yoilsho	5330	36	in	in	IN
cord-006229-7yoilsho	5330	37	addition	addition	NN
cord-006229-7yoilsho	5330	38	to	to	IN
cord-006229-7yoilsho	5330	39	their	-PRON-	PRP$
cord-006229-7yoilsho	5330	40	personal	personal	JJ
cord-006229-7yoilsho	5330	41	specialised	specialised	JJ
cord-006229-7yoilsho	5330	42	scientific	scientific	JJ
cord-006229-7yoilsho	5330	43	expertise	expertise	NN
cord-006229-7yoilsho	5330	44	,	,	,
cord-006229-7yoilsho	5330	45	covers	cover	VBZ
cord-006229-7yoilsho	5330	46	expert	expert	JJ
cord-006229-7yoilsho	5330	47	knowledge	knowledge	NN
cord-006229-7yoilsho	5330	48	in	in	IN
cord-006229-7yoilsho	5330	49	all	all	DT
cord-006229-7yoilsho	5330	50	major	major	JJ
cord-006229-7yoilsho	5330	51	fields	field	NNS
cord-006229-7yoilsho	5330	52	of	of	IN
cord-006229-7yoilsho	5330	53	the	the	DT
cord-006229-7yoilsho	5330	54	discipline	discipline	NN
cord-006229-7yoilsho	5330	55	.	.	.
cord-006229-7yoilsho	5331	1	Seventeen	seventeen	CD
cord-006229-7yoilsho	5331	2	EPHAR	EPHAR	NNP
cord-006229-7yoilsho	5331	3	member	member	NN
cord-006229-7yoilsho	5331	4	societies	society	NNS
cord-006229-7yoilsho	5331	5	have	have	VBP
cord-006229-7yoilsho	5331	6	declared	declare	VBN
cord-006229-7yoilsho	5331	7	their	-PRON-	PRP$
cord-006229-7yoilsho	5331	8	active	active	JJ
cord-006229-7yoilsho	5331	9	participation	participation	NN
cord-006229-7yoilsho	5331	10	in	in	IN
cord-006229-7yoilsho	5331	11	the	the	DT
cord-006229-7yoilsho	5331	12	EuCP	EuCP	NNP
cord-006229-7yoilsho	5331	13	programme	programme	NN
cord-006229-7yoilsho	5331	14	so	so	RB
cord-006229-7yoilsho	5331	15	far	far	RB
cord-006229-7yoilsho	5331	16	(	(	-LRB-
cord-006229-7yoilsho	5331	17	Austria	Austria	NNP
cord-006229-7yoilsho	5331	18	,	,	,
cord-006229-7yoilsho	5331	19	Croatia	Croatia	NNP
cord-006229-7yoilsho	5331	20	,	,	,
cord-006229-7yoilsho	5331	21	Czech	Czech	NNP
cord-006229-7yoilsho	5331	22	Republic	Republic	NNP
cord-006229-7yoilsho	5331	23	,	,	,
cord-006229-7yoilsho	5331	24	Finland	Finland	NNP
cord-006229-7yoilsho	5331	25	,	,	,
cord-006229-7yoilsho	5331	26	France	France	NNP
cord-006229-7yoilsho	5331	27	,	,	,
cord-006229-7yoilsho	5331	28	Germany	Germany	NNP
cord-006229-7yoilsho	5331	29	,	,	,
cord-006229-7yoilsho	5331	30	Greece	Greece	NNP
cord-006229-7yoilsho	5331	31	,	,	,
cord-006229-7yoilsho	5331	32	Hungary	Hungary	NNP
cord-006229-7yoilsho	5331	33	,	,	,
cord-006229-7yoilsho	5331	34	Italy	Italy	NNP
cord-006229-7yoilsho	5331	35	,	,	,
cord-006229-7yoilsho	5331	36	the	the	DT
cord-006229-7yoilsho	5331	37	Netherlands	Netherlands	NNP
cord-006229-7yoilsho	5331	38	,	,	,
cord-006229-7yoilsho	5331	39	Norway	Norway	NNP
cord-006229-7yoilsho	5331	40	,	,	,
cord-006229-7yoilsho	5331	41	Poland	Poland	NNP
cord-006229-7yoilsho	5331	42	,	,	,
cord-006229-7yoilsho	5331	43	Portugal	Portugal	NNP
cord-006229-7yoilsho	5331	44	,	,	,
cord-006229-7yoilsho	5331	45	Serbia	Serbia	NNP
cord-006229-7yoilsho	5331	46	,	,	,
cord-006229-7yoilsho	5331	47	Slovenia	Slovenia	NNP
cord-006229-7yoilsho	5331	48	,	,	,
cord-006229-7yoilsho	5331	49	Spain	Spain	NNP
cord-006229-7yoilsho	5331	50	,	,	,
cord-006229-7yoilsho	5331	51	Turkey	Turkey	NNP
cord-006229-7yoilsho	5331	52	)	)	-RRB-
cord-006229-7yoilsho	5331	53	.	.	.
cord-006229-7yoilsho	5332	1	EACPT	EACPT	NNP
cord-006229-7yoilsho	5332	2	,	,	,
cord-006229-7yoilsho	5332	3	the	the	DT
cord-006229-7yoilsho	5332	4	European	European	NNP
cord-006229-7yoilsho	5332	5	Association	Association	NNP
cord-006229-7yoilsho	5332	6	of	of	IN
cord-006229-7yoilsho	5332	7	Clinical	Clinical	NNP
cord-006229-7yoilsho	5332	8	Pharmacology	Pharmacology	NNP
cord-006229-7yoilsho	5332	9	and	and	CC
cord-006229-7yoilsho	5332	10	Therapeutics	Therapeutics	NNP
cord-006229-7yoilsho	5332	11	,	,	,
cord-006229-7yoilsho	5332	12	has	have	VBZ
cord-006229-7yoilsho	5332	13	also	also	RB
cord-006229-7yoilsho	5332	14	recently	recently	RB
cord-006229-7yoilsho	5332	15	decided	decide	VBN
cord-006229-7yoilsho	5332	16	to	to	TO
cord-006229-7yoilsho	5332	17	participate	participate	VB
cord-006229-7yoilsho	5332	18	in	in	IN
cord-006229-7yoilsho	5332	19	the	the	DT
cord-006229-7yoilsho	5332	20	EuCP	EuCP	NNP
cord-006229-7yoilsho	5332	21	Programme	Programme	NNP
cord-006229-7yoilsho	5332	22	.	.	.
cord-006229-7yoilsho	5333	1	National	national	JJ
cord-006229-7yoilsho	5333	2	programmes	programme	NNS
cord-006229-7yoilsho	5333	3	must	must	MD
cord-006229-7yoilsho	5333	4	meet	meet	VB
cord-006229-7yoilsho	5333	5	all	all	DT
cord-006229-7yoilsho	5333	6	requirements	requirement	NNS
cord-006229-7yoilsho	5333	7	of	of	IN
cord-006229-7yoilsho	5333	8	the	the	DT
cord-006229-7yoilsho	5333	9	EuCP	EuCP	NNP
cord-006229-7yoilsho	5333	10	Guidelines	guideline	NNS
cord-006229-7yoilsho	5333	11	including	include	VBG
cord-006229-7yoilsho	5333	12	a	a	DT
cord-006229-7yoilsho	5333	13	clear	clear	JJ
cord-006229-7yoilsho	5333	14	catalogue	catalogue	NN
cord-006229-7yoilsho	5333	15	of	of	IN
cord-006229-7yoilsho	5333	16	criteria	criterion	NNS
cord-006229-7yoilsho	5333	17	with	with	IN
cord-006229-7yoilsho	5333	18	respect	respect	NN
cord-006229-7yoilsho	5333	19	to	to	IN
cord-006229-7yoilsho	5333	20	knowledge	knowledge	NN
cord-006229-7yoilsho	5333	21	,	,	,
cord-006229-7yoilsho	5333	22	practical	practical	JJ
cord-006229-7yoilsho	5333	23	awareness	awareness	NN
cord-006229-7yoilsho	5333	24	and	and	CC
cord-006229-7yoilsho	5333	25	skills	skill	NNS
cord-006229-7yoilsho	5333	26	,	,	,
cord-006229-7yoilsho	5333	27	as	as	RB
cord-006229-7yoilsho	5333	28	well	well	RB
cord-006229-7yoilsho	5333	29	as	as	IN
cord-006229-7yoilsho	5333	30	general	general	JJ
cord-006229-7yoilsho	5333	31	rules	rule	NNS
cord-006229-7yoilsho	5333	32	including	include	VBG
cord-006229-7yoilsho	5333	33	rules	rule	NNS
cord-006229-7yoilsho	5333	34	for	for	IN
cord-006229-7yoilsho	5333	35	final	final	JJ
cord-006229-7yoilsho	5333	36	assessment	assessment	NN
cord-006229-7yoilsho	5333	37	of	of	IN
cord-006229-7yoilsho	5333	38	candidates	candidate	NNS
cord-006229-7yoilsho	5333	39	.	.	.
cord-006229-7yoilsho	5334	1	Such	such	JJ
cord-006229-7yoilsho	5334	2	programmes	programme	NNS
cord-006229-7yoilsho	5334	3	may	may	MD
cord-006229-7yoilsho	5334	4	be	be	VB
cord-006229-7yoilsho	5334	5	based	base	VBN
cord-006229-7yoilsho	5334	6	on	on	IN
cord-006229-7yoilsho	5334	7	existing	exist	VBG
cord-006229-7yoilsho	5334	8	diplomas	diploma	NNS
cord-006229-7yoilsho	5334	9	or	or	CC
cord-006229-7yoilsho	5334	10	training	training	NN
cord-006229-7yoilsho	5334	11	schemes	scheme	NNS
cord-006229-7yoilsho	5334	12	or	or	CC
cord-006229-7yoilsho	5334	13	may	may	MD
cord-006229-7yoilsho	5334	14	consist	consist	VB
cord-006229-7yoilsho	5334	15	of	of	IN
cord-006229-7yoilsho	5334	16	a	a	DT
cord-006229-7yoilsho	5334	17	set	set	NN
cord-006229-7yoilsho	5334	18	of	of	IN
cord-006229-7yoilsho	5334	19	rules	rule	NNS
cord-006229-7yoilsho	5334	20	how	how	WRB
cord-006229-7yoilsho	5334	21	applicants	applicant	NNS
cord-006229-7yoilsho	5334	22	may	may	MD
cord-006229-7yoilsho	5334	23	submit	submit	VB
cord-006229-7yoilsho	5334	24	credentials	credential	NNS
cord-006229-7yoilsho	5334	25	for	for	IN
cord-006229-7yoilsho	5334	26	their	-PRON-	PRP$
cord-006229-7yoilsho	5334	27	expertise	expertise	NN
cord-006229-7yoilsho	5334	28	with	with	IN
cord-006229-7yoilsho	5334	29	respect	respect	NN
cord-006229-7yoilsho	5334	30	to	to	IN
cord-006229-7yoilsho	5334	31	the	the	DT
cord-006229-7yoilsho	5334	32	EuCP	EuCP	NNP
cord-006229-7yoilsho	5334	33	criteria	criterion	NNS
cord-006229-7yoilsho	5334	34	.	.	.
cord-006229-7yoilsho	5335	1	So	so	RB
cord-006229-7yoilsho	5335	2	far	far	RB
cord-006229-7yoilsho	5335	3	,	,	,
cord-006229-7yoilsho	5335	4	three	three	CD
cord-006229-7yoilsho	5335	5	EPHAR	EPHAR	NNP
cord-006229-7yoilsho	5335	6	member	member	NN
cord-006229-7yoilsho	5335	7	societies	society	NNS
cord-006229-7yoilsho	5335	8	have	have	VBP
cord-006229-7yoilsho	5335	9	submitted	submit	VBN
cord-006229-7yoilsho	5335	10	a	a	DT
cord-006229-7yoilsho	5335	11	national	national	JJ
cord-006229-7yoilsho	5335	12	EuCP	EuCP	NNP
cord-006229-7yoilsho	5335	13	program	program	NN
cord-006229-7yoilsho	5335	14	:	:	:
cord-006229-7yoilsho	5335	15	Austria	Austria	NNP
cord-006229-7yoilsho	5335	16	,	,	,
cord-006229-7yoilsho	5335	17	Italy	Italy	NNP
cord-006229-7yoilsho	5335	18	and	and	CC
cord-006229-7yoilsho	5335	19	the	the	DT
cord-006229-7yoilsho	5335	20	Netherlands	Netherlands	NNP
cord-006229-7yoilsho	5335	21	.	.	.
cord-006229-7yoilsho	5336	1	The	the	DT
cord-006229-7yoilsho	5336	2	programmes	programme	NNS
cord-006229-7yoilsho	5336	3	differ	differ	VBP
cord-006229-7yoilsho	5336	4	in	in	IN
cord-006229-7yoilsho	5336	5	structure	structure	NN
cord-006229-7yoilsho	5336	6	and	and	CC
cord-006229-7yoilsho	5336	7	reflect	reflect	VB
cord-006229-7yoilsho	5336	8	the	the	DT
cord-006229-7yoilsho	5336	9	flexibility	flexibility	NN
cord-006229-7yoilsho	5336	10	of	of	IN
cord-006229-7yoilsho	5336	11	the	the	DT
cord-006229-7yoilsho	5336	12	EuCP	EuCP	NNP
cord-006229-7yoilsho	5336	13	Programme	Programme	NNP
cord-006229-7yoilsho	5336	14	with	with	IN
cord-006229-7yoilsho	5336	15	respect	respect	NN
cord-006229-7yoilsho	5336	16	to	to	IN
cord-006229-7yoilsho	5336	17	the	the	DT
cord-006229-7yoilsho	5336	18	respective	respective	JJ
cord-006229-7yoilsho	5336	19	national	national	JJ
cord-006229-7yoilsho	5336	20	conditions	condition	NNS
cord-006229-7yoilsho	5336	21	.	.	.
cord-006229-7yoilsho	5337	1	While	while	IN
cord-006229-7yoilsho	5337	2	the	the	DT
cord-006229-7yoilsho	5337	3	Italian	italian	JJ
cord-006229-7yoilsho	5337	4	programme	programme	NN
cord-006229-7yoilsho	5337	5	is	be	VBZ
cord-006229-7yoilsho	5337	6	based	base	VBN
cord-006229-7yoilsho	5337	7	on	on	IN
cord-006229-7yoilsho	5337	8	a	a	DT
cord-006229-7yoilsho	5337	9	catalogue	catalogue	NN
cord-006229-7yoilsho	5337	10	of	of	IN
cord-006229-7yoilsho	5337	11	criteria	criterion	NNS
cord-006229-7yoilsho	5337	12	where	where	WRB
cord-006229-7yoilsho	5337	13	applicants	applicant	NNS
cord-006229-7yoilsho	5337	14	have	have	VBP
cord-006229-7yoilsho	5337	15	to	to	TO
cord-006229-7yoilsho	5337	16	certify	certify	VB
cord-006229-7yoilsho	5337	17	and	and	CC
cord-006229-7yoilsho	5337	18	document	document	VB
cord-006229-7yoilsho	5337	19	their	-PRON-	PRP$
cord-006229-7yoilsho	5337	20	expertise	expertise	NN
cord-006229-7yoilsho	5337	21	on	on	IN
cord-006229-7yoilsho	5337	22	the	the	DT
cord-006229-7yoilsho	5337	23	basis	basis	NN
cord-006229-7yoilsho	5337	24	of	of	IN
cord-006229-7yoilsho	5337	25	this	this	DT
cord-006229-7yoilsho	5337	26	catalogue	catalogue	NN
cord-006229-7yoilsho	5337	27	and	and	CC
cord-006229-7yoilsho	5337	28	the	the	DT
cord-006229-7yoilsho	5337	29	Dutch	dutch	JJ
cord-006229-7yoilsho	5337	30	program	program	NN
cord-006229-7yoilsho	5337	31	is	be	VBZ
cord-006229-7yoilsho	5337	32	based	base	VBN
cord-006229-7yoilsho	5337	33	on	on	IN
cord-006229-7yoilsho	5337	34	a	a	DT
cord-006229-7yoilsho	5337	35	structured	structured	JJ
cord-006229-7yoilsho	5337	36	PhD	phd	NN
cord-006229-7yoilsho	5337	37	training	training	NN
cord-006229-7yoilsho	5337	38	course	course	NN
cord-006229-7yoilsho	5337	39	,	,	,
cord-006229-7yoilsho	5337	40	the	the	DT
cord-006229-7yoilsho	5337	41	EuCP	EuCP	NNP
cord-006229-7yoilsho	5337	42	scheme	scheme	NN
cord-006229-7yoilsho	5337	43	submitted	submit	VBN
cord-006229-7yoilsho	5337	44	by	by	IN
cord-006229-7yoilsho	5337	45	the	the	DT
cord-006229-7yoilsho	5337	46	Austrian	Austrian	NNP
cord-006229-7yoilsho	5337	47	Pharmacological	Pharmacological	NNP
cord-006229-7yoilsho	5337	48	Society	Society	NNP
cord-006229-7yoilsho	5337	49	APHAR	APHAR	NNP
cord-006229-7yoilsho	5337	50	is	be	VBZ
cord-006229-7yoilsho	5337	51	based	base	VBN
cord-006229-7yoilsho	5337	52	on	on	IN
cord-006229-7yoilsho	5337	53	the	the	DT
cord-006229-7yoilsho	5337	54	legally	legally	RB
cord-006229-7yoilsho	5337	55	regulated	regulate	VBN
cord-006229-7yoilsho	5337	56	diploma	diploma	NN
cord-006229-7yoilsho	5337	57	Medical	Medical	NNP
cord-006229-7yoilsho	5337	58	Specialist	Specialist	NNP
cord-006229-7yoilsho	5337	59	(	(	-LRB-
cord-006229-7yoilsho	5337	60	Facharzt	Facharzt	NNP
cord-006229-7yoilsho	5337	61	)	)	-RRB-
cord-006229-7yoilsho	5337	62	in	in	IN
cord-006229-7yoilsho	5337	63	Pharmacology	Pharmacology	NNP
cord-006229-7yoilsho	5337	64	and	and	CC
cord-006229-7yoilsho	5337	65	Toxicology	Toxicology	NNP
cord-006229-7yoilsho	5337	66	(	(	-LRB-
cord-006229-7yoilsho	5337	67	APHAR	APHAR	NNP
cord-006229-7yoilsho	5337	68	also	also	RB
cord-006229-7yoilsho	5337	69	plans	plan	VBZ
cord-006229-7yoilsho	5337	70	to	to	TO
cord-006229-7yoilsho	5337	71	submit	submit	VB
cord-006229-7yoilsho	5337	72	separate	separate	JJ
cord-006229-7yoilsho	5337	73	regulations	regulation	NNS
cord-006229-7yoilsho	5337	74	for	for	IN
cord-006229-7yoilsho	5337	75	specialists	specialist	NNS
cord-006229-7yoilsho	5337	76	in	in	IN
cord-006229-7yoilsho	5337	77	clinical	clinical	JJ
cord-006229-7yoilsho	5337	78	pharmacology	pharmacology	NN
cord-006229-7yoilsho	5337	79	and	and	CC
cord-006229-7yoilsho	5337	80	for	for	IN
cord-006229-7yoilsho	5337	81	nonmedically	nonmedically	RB
cord-006229-7yoilsho	5337	82	qualified	qualified	JJ
cord-006229-7yoilsho	5337	83	pharmacologists	pharmacologist	NNS
cord-006229-7yoilsho	5337	84	)	)	-RRB-
cord-006229-7yoilsho	5337	85	.	.	.
cord-006229-7yoilsho	5338	1	The	the	DT
cord-006229-7yoilsho	5338	2	APHAR	APHAR	NNP
cord-006229-7yoilsho	5338	3	EuCP	eucp	NN
cord-006229-7yoilsho	5338	4	scheme	scheme	NN
cord-006229-7yoilsho	5338	5	has	have	VBZ
cord-006229-7yoilsho	5338	6	been	be	VBN
cord-006229-7yoilsho	5338	7	approved	approve	VBN
cord-006229-7yoilsho	5338	8	by	by	IN
cord-006229-7yoilsho	5338	9	the	the	DT
cord-006229-7yoilsho	5338	10	EuCP	EuCP	NNP
cord-006229-7yoilsho	5338	11	Committee	Committee	NNP
cord-006229-7yoilsho	5338	12	in	in	IN
cord-006229-7yoilsho	5338	13	November	November	NNP
cord-006229-7yoilsho	5338	14	2015	2015	CD
cord-006229-7yoilsho	5338	15	and	and	CC
cord-006229-7yoilsho	5338	16	its	-PRON-	PRP$
cord-006229-7yoilsho	5338	17	regulations	regulation	NNS
cord-006229-7yoilsho	5338	18	are	be	VBP
cord-006229-7yoilsho	5338	19	available	available	JJ
cord-006229-7yoilsho	5338	20	on	on	IN
cord-006229-7yoilsho	5338	21	the	the	DT
cord-006229-7yoilsho	5338	22	EuCP	EuCP	NNP
cord-006229-7yoilsho	5338	23	website	website	NN
cord-006229-7yoilsho	5338	24	(	(	-LRB-
cord-006229-7yoilsho	5338	25	www.eucp-certification.org	www.eucp-certification.org	NFP
cord-006229-7yoilsho	5338	26	)	)	-RRB-
cord-006229-7yoilsho	5338	27	.	.	.
cord-006229-7yoilsho	5339	1	The	the	DT
cord-006229-7yoilsho	5339	2	differently	differently	RB
cord-006229-7yoilsho	5339	3	structured	structured	JJ
cord-006229-7yoilsho	5339	4	programs	program	NNS
cord-006229-7yoilsho	5339	5	of	of	IN
cord-006229-7yoilsho	5339	6	the	the	DT
cord-006229-7yoilsho	5339	7	Italian	italian	JJ
cord-006229-7yoilsho	5339	8	and	and	CC
cord-006229-7yoilsho	5339	9	Dutch	Dutch	NNP
cord-006229-7yoilsho	5339	10	Pharmacological	Pharmacological	NNP
cord-006229-7yoilsho	5339	11	Societies	Societies	NNPS
cord-006229-7yoilsho	5339	12	will	will	MD
cord-006229-7yoilsho	5339	13	also	also	RB
cord-006229-7yoilsho	5339	14	be	be	VB
cord-006229-7yoilsho	5339	15	available	available	JJ
cord-006229-7yoilsho	5339	16	at	at	IN
cord-006229-7yoilsho	5339	17	this	this	DT
cord-006229-7yoilsho	5339	18	website	website	NN
cord-006229-7yoilsho	5339	19	,	,	,
cord-006229-7yoilsho	5339	20	once	once	RB
cord-006229-7yoilsho	5339	21	approved	approve	VBN
cord-006229-7yoilsho	5339	22	by	by	IN
cord-006229-7yoilsho	5339	23	the	the	DT
cord-006229-7yoilsho	5339	24	EuCP	EuCP	NNP
cord-006229-7yoilsho	5339	25	Committee	Committee	NNP
cord-006229-7yoilsho	5339	26	and	and	CC
cord-006229-7yoilsho	5339	27	may	may	MD
cord-006229-7yoilsho	5339	28	thus	thus	RB
cord-006229-7yoilsho	5339	29	serve	serve	VB
cord-006229-7yoilsho	5339	30	as	as	IN
cord-006229-7yoilsho	5339	31	'	'	``
cord-006229-7yoilsho	5339	32	case	case	NN
cord-006229-7yoilsho	5339	33	studies	study	NNS
cord-006229-7yoilsho	5339	34	'	'	''
cord-006229-7yoilsho	5339	35	for	for	IN
cord-006229-7yoilsho	5339	36	other	other	JJ
cord-006229-7yoilsho	5339	37	EPHAR	EPHAR	NNP
cord-006229-7yoilsho	5339	38	and	and	CC
cord-006229-7yoilsho	5339	39	EACPT	EACPT	NNP
cord-006229-7yoilsho	5339	40	member	member	NN
cord-006229-7yoilsho	5339	41	societies	society	NNS
cord-006229-7yoilsho	5339	42	wishing	wish	VBG
cord-006229-7yoilsho	5339	43	to	to	TO
cord-006229-7yoilsho	5339	44	take	take	VB
cord-006229-7yoilsho	5339	45	part	part	NN
cord-006229-7yoilsho	5339	46	in	in	IN
cord-006229-7yoilsho	5339	47	the	the	DT
cord-006229-7yoilsho	5339	48	EuCP	EuCP	NNP
cord-006229-7yoilsho	5339	49	Programme	Programme	NNP
cord-006229-7yoilsho	5339	50	.	.	.
cord-006229-7yoilsho	5340	1	Introduction	introduction	NN
cord-006229-7yoilsho	5340	2	:	:	:
cord-006229-7yoilsho	5341	1	The	the	DT
cord-006229-7yoilsho	5341	2	outstanding	outstanding	JJ
cord-006229-7yoilsho	5341	3	importance	importance	NN
cord-006229-7yoilsho	5341	4	of	of	IN
cord-006229-7yoilsho	5341	5	pharmacovigilance	pharmacovigilance	NN
cord-006229-7yoilsho	5341	6	(	(	-LRB-
cord-006229-7yoilsho	5341	7	PV	PV	NNP
cord-006229-7yoilsho	5341	8	)	)	-RRB-
cord-006229-7yoilsho	5341	9	for	for	IN
cord-006229-7yoilsho	5341	10	the	the	DT
cord-006229-7yoilsho	5341	11	safe	safe	JJ
cord-006229-7yoilsho	5341	12	use	use	NN
cord-006229-7yoilsho	5341	13	of	of	IN
cord-006229-7yoilsho	5341	14	medicines	medicine	NNS
cord-006229-7yoilsho	5341	15	has	have	VBZ
cord-006229-7yoilsho	5341	16	increasingly	increasingly	RB
cord-006229-7yoilsho	5341	17	been	be	VBN
cord-006229-7yoilsho	5341	18	recognised	recognise	VBN
cord-006229-7yoilsho	5341	19	during	during	IN
cord-006229-7yoilsho	5341	20	recent	recent	JJ
cord-006229-7yoilsho	5341	21	years	year	NNS
cord-006229-7yoilsho	5341	22	.	.	.
cord-006229-7yoilsho	5342	1	The	the	DT
cord-006229-7yoilsho	5342	2	multidisciplinary	multidisciplinary	JJ
cord-006229-7yoilsho	5342	3	character	character	NN
cord-006229-7yoilsho	5342	4	of	of	IN
cord-006229-7yoilsho	5342	5	PV	PV	NNP
cord-006229-7yoilsho	5342	6	requires	require	VBZ
cord-006229-7yoilsho	5342	7	know	know	NN
cord-006229-7yoilsho	5342	8	-	-	HYPH
cord-006229-7yoilsho	5342	9	how	how	NN
cord-006229-7yoilsho	5342	10	in	in	IN
cord-006229-7yoilsho	5342	11	topics	topic	NNS
cord-006229-7yoilsho	5342	12	as	as	RB
cord-006229-7yoilsho	5342	13	different	different	JJ
cord-006229-7yoilsho	5342	14	as	as	IN
cord-006229-7yoilsho	5342	15	pharmacology	pharmacology	NN
cord-006229-7yoilsho	5342	16	,	,	,
cord-006229-7yoilsho	5342	17	clinical	clinical	JJ
cord-006229-7yoilsho	5342	18	medicine	medicine	NN
cord-006229-7yoilsho	5342	19	,	,	,
cord-006229-7yoilsho	5342	20	pharmacoepidemiology	pharmacoepidemiology	NN
cord-006229-7yoilsho	5342	21	,	,	,
cord-006229-7yoilsho	5342	22	information	information	NN
cord-006229-7yoilsho	5342	23	technology	technology	NN
cord-006229-7yoilsho	5342	24	,	,	,
cord-006229-7yoilsho	5342	25	pharmaceutical	pharmaceutical	NN
cord-006229-7yoilsho	5342	26	manufacturing	manufacturing	NN
cord-006229-7yoilsho	5342	27	,	,	,
cord-006229-7yoilsho	5342	28	legal	legal	JJ
cord-006229-7yoilsho	5342	29	aspects	aspect	NNS
cord-006229-7yoilsho	5342	30	,	,	,
cord-006229-7yoilsho	5342	31	public	public	JJ
cord-006229-7yoilsho	5342	32	health	health	NN
cord-006229-7yoilsho	5342	33	policies	policy	NNS
cord-006229-7yoilsho	5342	34	,	,	,
cord-006229-7yoilsho	5342	35	and	and	CC
cord-006229-7yoilsho	5342	36	medical	medical	JJ
cord-006229-7yoilsho	5342	37	traditions	tradition	NNS
cord-006229-7yoilsho	5342	38	in	in	IN
cord-006229-7yoilsho	5342	39	different	different	JJ
cord-006229-7yoilsho	5342	40	regions	region	NNS
cord-006229-7yoilsho	5342	41	of	of	IN
cord-006229-7yoilsho	5342	42	the	the	DT
cord-006229-7yoilsho	5342	43	world	world	NN
cord-006229-7yoilsho	5342	44	.	.	.
cord-006229-7yoilsho	5343	1	In	in	IN
cord-006229-7yoilsho	5343	2	this	this	DT
cord-006229-7yoilsho	5343	3	complex	complex	JJ
cord-006229-7yoilsho	5343	4	situation	situation	NN
cord-006229-7yoilsho	5343	5	There	there	EX
cord-006229-7yoilsho	5343	6	is	be	VBZ
cord-006229-7yoilsho	5343	7	a	a	DT
cord-006229-7yoilsho	5343	8	growing	grow	VBG
cord-006229-7yoilsho	5343	9	need	need	NN
cord-006229-7yoilsho	5343	10	for	for	IN
cord-006229-7yoilsho	5343	11	PV	pv	NN
cord-006229-7yoilsho	5343	12	capacity	capacity	NN
cord-006229-7yoilsho	5343	13	building	building	NN
cord-006229-7yoilsho	5343	14	,	,	,
cord-006229-7yoilsho	5343	15	in	in	IN
cord-006229-7yoilsho	5343	16	particular	particular	JJ
cord-006229-7yoilsho	5343	17	by	by	IN
cord-006229-7yoilsho	5343	18	professional	professional	JJ
cord-006229-7yoilsho	5343	19	training	training	NN
cord-006229-7yoilsho	5343	20	through	through	IN
cord-006229-7yoilsho	5343	21	high	high	JJ
cord-006229-7yoilsho	5343	22	quality	quality	NN
cord-006229-7yoilsho	5343	23	PV	pv	NN
cord-006229-7yoilsho	5343	24	courses	course	NNS
cord-006229-7yoilsho	5343	25	with	with	IN
cord-006229-7yoilsho	5343	26	different	different	JJ
cord-006229-7yoilsho	5343	27	focuses	focus	NNS
cord-006229-7yoilsho	5343	28	and	and	CC
cord-006229-7yoilsho	5343	29	different	different	JJ
cord-006229-7yoilsho	5343	30	levels	level	NNS
cord-006229-7yoilsho	5343	31	of	of	IN
cord-006229-7yoilsho	5343	32	detailing	detailing	NN
cord-006229-7yoilsho	5343	33	.	.	.
cord-006229-7yoilsho	5344	1	Against	against	IN
cord-006229-7yoilsho	5344	2	this	this	DT
cord-006229-7yoilsho	5344	3	background	background	NN
cord-006229-7yoilsho	5344	4	,	,	,
cord-006229-7yoilsho	5344	5	the	the	DT
cord-006229-7yoilsho	5344	6	World	World	NNP
cord-006229-7yoilsho	5344	7	Health	Health	NNP
cord-006229-7yoilsho	5344	8	Organization	Organization	NNP
cord-006229-7yoilsho	5344	9	(	(	-LRB-
cord-006229-7yoilsho	5344	10	WHO	who	WP
cord-006229-7yoilsho	5344	11	)	)	-RRB-
cord-006229-7yoilsho	5344	12	and	and	CC
cord-006229-7yoilsho	5344	13	the	the	DT
cord-006229-7yoilsho	5344	14	International	International	NNP
cord-006229-7yoilsho	5344	15	Society	Society	NNP
cord-006229-7yoilsho	5344	16	of	of	IN
cord-006229-7yoilsho	5344	17	Pharmacovigilance	Pharmacovigilance	NNP
cord-006229-7yoilsho	5344	18	(	(	-LRB-
cord-006229-7yoilsho	5344	19	ISoP	isop	NN
cord-006229-7yoilsho	5344	20	)	)	-RRB-
cord-006229-7yoilsho	5344	21	have	have	VBP
cord-006229-7yoilsho	5344	22	co	co	VBN
cord-006229-7yoilsho	5344	23	-	-	VBN
cord-006229-7yoilsho	5344	24	operated	operate	VBN
cord-006229-7yoilsho	5344	25	to	to	TO
cord-006229-7yoilsho	5344	26	create	create	VB
cord-006229-7yoilsho	5344	27	a	a	DT
cord-006229-7yoilsho	5344	28	curriculum	curriculum	NN
cord-006229-7yoilsho	5344	29	for	for	IN
cord-006229-7yoilsho	5344	30	teaching	teach	VBG
cord-006229-7yoilsho	5344	31	PV	pv	NN
cord-006229-7yoilsho	5344	32	which	which	WDT
cord-006229-7yoilsho	5344	33	can	can	MD
cord-006229-7yoilsho	5344	34	be	be	VB
cord-006229-7yoilsho	5344	35	used	use	VBN
cord-006229-7yoilsho	5344	36	for	for	IN
cord-006229-7yoilsho	5344	37	a	a	DT
cord-006229-7yoilsho	5344	38	wide	wide	JJ
cord-006229-7yoilsho	5344	39	range	range	NN
cord-006229-7yoilsho	5344	40	of	of	IN
cord-006229-7yoilsho	5344	41	audiences	audience	NNS
cord-006229-7yoilsho	5344	42	and	and	CC
cord-006229-7yoilsho	5344	43	in	in	IN
cord-006229-7yoilsho	5344	44	very	very	RB
cord-006229-7yoilsho	5344	45	different	different	JJ
cord-006229-7yoilsho	5344	46	settings	setting	NNS
cord-006229-7yoilsho	5344	47	and	and	CC
cord-006229-7yoilsho	5344	48	situations	situation	NNS
cord-006229-7yoilsho	5344	49	.	.	.
cord-006229-7yoilsho	5345	1	The	the	DT
cord-006229-7yoilsho	5345	2	purpose	purpose	NN
cord-006229-7yoilsho	5345	3	was	be	VBD
cord-006229-7yoilsho	5345	4	to	to	TO
cord-006229-7yoilsho	5345	5	provide	provide	VB
cord-006229-7yoilsho	5345	6	an	an	DT
cord-006229-7yoilsho	5345	7	inventory	inventory	NN
cord-006229-7yoilsho	5345	8	and	and	CC
cord-006229-7yoilsho	5345	9	systematically	systematically	RB
cord-006229-7yoilsho	5345	10	structured	structured	JJ
cord-006229-7yoilsho	5345	11	overview	overview	NN
cord-006229-7yoilsho	5345	12	of	of	IN
cord-006229-7yoilsho	5345	13	PV	PV	NNP
cord-006229-7yoilsho	5345	14	including	include	VBG
cord-006229-7yoilsho	5345	15	recent	recent	JJ
cord-006229-7yoilsho	5345	16	developments	development	NNS
cord-006229-7yoilsho	5345	17	of	of	IN
cord-006229-7yoilsho	5345	18	topics	topic	NNS
cord-006229-7yoilsho	5345	19	like	like	IN
cord-006229-7yoilsho	5345	20	pharmacogenomics	pharmacogenomic	NNS
cord-006229-7yoilsho	5345	21	,	,	,
cord-006229-7yoilsho	5345	22	consumer	consumer	NN
cord-006229-7yoilsho	5345	23	reporting	reporting	NN
cord-006229-7yoilsho	5345	24	of	of	IN
cord-006229-7yoilsho	5345	25	ADRs	adr	NNS
cord-006229-7yoilsho	5345	26	,	,	,
cord-006229-7yoilsho	5345	27	risk	risk	NN
cord-006229-7yoilsho	5345	28	management	management	NN
cord-006229-7yoilsho	5345	29	and	and	CC
cord-006229-7yoilsho	5345	30	WHO	who	WP
cord-006229-7yoilsho	5345	31	-	-	HYPH
cord-006229-7yoilsho	5345	32	led	lead	VBN
cord-006229-7yoilsho	5345	33	international	international	JJ
cord-006229-7yoilsho	5345	34	projects	project	NNS
cord-006229-7yoilsho	5345	35	,	,	,
cord-006229-7yoilsho	5345	36	and	and	CC
cord-006229-7yoilsho	5345	37	to	to	TO
cord-006229-7yoilsho	5345	38	propose	propose	VB
cord-006229-7yoilsho	5345	39	a	a	DT
cord-006229-7yoilsho	5345	40	range	range	NN
cord-006229-7yoilsho	5345	41	of	of	IN
cord-006229-7yoilsho	5345	42	tasks	task	NNS
cord-006229-7yoilsho	5345	43	for	for	IN
cord-006229-7yoilsho	5345	44	practical	practical	JJ
cord-006229-7yoilsho	5345	45	training	training	NN
cord-006229-7yoilsho	5345	46	.	.	.
cord-006229-7yoilsho	5346	1	We	-PRON-	PRP
cord-006229-7yoilsho	5346	2	made	make	VBD
cord-006229-7yoilsho	5346	3	use	use	NN
cord-006229-7yoilsho	5346	4	of	of	IN
cord-006229-7yoilsho	5346	5	several	several	JJ
cord-006229-7yoilsho	5346	6	relevant	relevant	JJ
cord-006229-7yoilsho	5346	7	already	already	RB
cord-006229-7yoilsho	5346	8	existing	exist	VBG
cord-006229-7yoilsho	5346	9	packages	package	NNS
cord-006229-7yoilsho	5346	10	of	of	IN
cord-006229-7yoilsho	5346	11	PV	pv	NN
cord-006229-7yoilsho	5346	12	topics	topic	NNS
cord-006229-7yoilsho	5346	13	and	and	CC
cord-006229-7yoilsho	5346	14	concepts	concept	NNS
cord-006229-7yoilsho	5346	15	of	of	IN
cord-006229-7yoilsho	5346	16	PV	pv	NN
cord-006229-7yoilsho	5346	17	teaching	teach	VBG
cord-006229-7yoilsho	5346	18	from	from	IN
cord-006229-7yoilsho	5346	19	national	national	JJ
cord-006229-7yoilsho	5346	20	and	and	CC
cord-006229-7yoilsho	5346	21	international	international	JJ
cord-006229-7yoilsho	5346	22	institutions	institution	NNS
cord-006229-7yoilsho	5346	23	.	.	.
cord-006229-7yoilsho	5347	1	We	-PRON-	PRP
cord-006229-7yoilsho	5347	2	also	also	RB
cord-006229-7yoilsho	5347	3	drew	draw	VBD
cord-006229-7yoilsho	5347	4	from	from	IN
cord-006229-7yoilsho	5347	5	extensive	extensive	JJ
cord-006229-7yoilsho	5347	6	printed	print	VBN
cord-006229-7yoilsho	5347	7	material	material	NN
cord-006229-7yoilsho	5347	8	as	as	RB
cord-006229-7yoilsho	5347	9	well	well	RB
cord-006229-7yoilsho	5347	10	as	as	IN
cord-006229-7yoilsho	5347	11	comprehensive	comprehensive	JJ
cord-006229-7yoilsho	5347	12	reviews	review	NNS
cord-006229-7yoilsho	5347	13	,	,	,
cord-006229-7yoilsho	5347	14	textbooks	textbook	NNS
cord-006229-7yoilsho	5347	15	and	and	CC
cord-006229-7yoilsho	5347	16	guidelines	guideline	NNS
cord-006229-7yoilsho	5347	17	developed	develop	VBN
cord-006229-7yoilsho	5347	18	by	by	IN
cord-006229-7yoilsho	5347	19	international	international	JJ
cord-006229-7yoilsho	5347	20	organisations	organisation	NNS
cord-006229-7yoilsho	5347	21	which	which	WDT
cord-006229-7yoilsho	5347	22	are	be	VBP
cord-006229-7yoilsho	5347	23	often	often	RB
cord-006229-7yoilsho	5347	24	available	available	JJ
cord-006229-7yoilsho	5347	25	online	online	RB
cord-006229-7yoilsho	5347	26	.	.	.
cord-006229-7yoilsho	5348	1	Results	result	NNS
cord-006229-7yoilsho	5348	2	:	:	:
cord-006229-7yoilsho	5349	1	The	the	DT
cord-006229-7yoilsho	5349	2	curriculum	curriculum	NN
cord-006229-7yoilsho	5349	3	includes	include	VBZ
cord-006229-7yoilsho	5349	4	a	a	DT
cord-006229-7yoilsho	5349	5	main	main	JJ
cord-006229-7yoilsho	5349	6	component	component	NN
cord-006229-7yoilsho	5349	7	consisting	consist	VBG
cord-006229-7yoilsho	5349	8	of	of	IN
cord-006229-7yoilsho	5349	9	a	a	DT
cord-006229-7yoilsho	5349	10	major	major	JJ
cord-006229-7yoilsho	5349	11	part	part	NN
cord-006229-7yoilsho	5349	12	for	for	IN
cord-006229-7yoilsho	5349	13	theoretical	theoretical	JJ
cord-006229-7yoilsho	5349	14	lecture	lecture	NN
cord-006229-7yoilsho	5349	15	-	-	HYPH
cord-006229-7yoilsho	5349	16	based	base	VBN
cord-006229-7yoilsho	5349	17	training	training	NN
cord-006229-7yoilsho	5349	18	and	and	CC
cord-006229-7yoilsho	5349	19	a	a	DT
cord-006229-7yoilsho	5349	20	minor	minor	JJ
cord-006229-7yoilsho	5349	21	component	component	NN
cord-006229-7yoilsho	5349	22	with	with	IN
cord-006229-7yoilsho	5349	23	suggestions	suggestion	NNS
cord-006229-7yoilsho	5349	24	for	for	IN
cord-006229-7yoilsho	5349	25	hands	hand	NNS
cord-006229-7yoilsho	5349	26	-	-	HYPH
cord-006229-7yoilsho	5349	27	on	on	RP
cord-006229-7yoilsho	5349	28	exercises	exercise	NNS
cord-006229-7yoilsho	5349	29	.	.	.
cord-006229-7yoilsho	5350	1	The	the	DT
cord-006229-7yoilsho	5350	2	theoretical	theoretical	JJ
cord-006229-7yoilsho	5350	3	part	part	NN
cord-006229-7yoilsho	5350	4	has	have	VBZ
cord-006229-7yoilsho	5350	5	a	a	DT
cord-006229-7yoilsho	5350	6	three	three	CD
cord-006229-7yoilsho	5350	7	-	-	HYPH
cord-006229-7yoilsho	5350	8	level	level	NN
cord-006229-7yoilsho	5350	9	hierarchical	hierarchical	JJ
cord-006229-7yoilsho	5350	10	and	and	CC
cord-006229-7yoilsho	5350	11	modular	modular	JJ
cord-006229-7yoilsho	5350	12	structure	structure	NN
cord-006229-7yoilsho	5350	13	with	with	IN
cord-006229-7yoilsho	5350	14	evenly	evenly	RB
cord-006229-7yoilsho	5350	15	divided	divide	VBN
cord-006229-7yoilsho	5350	16	tiers	tier	NNS
cord-006229-7yoilsho	5350	17	.	.	.
cord-006229-7yoilsho	5351	1	There	there	EX
cord-006229-7yoilsho	5351	2	are	be	VBP
cord-006229-7yoilsho	5351	3	15	15	CD
cord-006229-7yoilsho	5351	4	chapters	chapter	NNS
cord-006229-7yoilsho	5351	5	.	.	.
cord-006229-7yoilsho	5352	1	Each	each	DT
cord-006229-7yoilsho	5352	2	of	of	IN
cord-006229-7yoilsho	5352	3	them	-PRON-	PRP
cord-006229-7yoilsho	5352	4	is	be	VBZ
cord-006229-7yoilsho	5352	5	divided	divide	VBN
cord-006229-7yoilsho	5352	6	into	into	IN
cord-006229-7yoilsho	5352	7	four	four	CD
cord-006229-7yoilsho	5352	8	sections	section	NNS
cord-006229-7yoilsho	5352	9	and	and	CC
cord-006229-7yoilsho	5352	10	each	each	DT
cord-006229-7yoilsho	5352	11	section	section	NN
cord-006229-7yoilsho	5352	12	into	into	IN
cord-006229-7yoilsho	5352	13	four	four	CD
cord-006229-7yoilsho	5352	14	to	to	TO
cord-006229-7yoilsho	5352	15	six	six	CD
cord-006229-7yoilsho	5352	16	sub	sub	NN
cord-006229-7yoilsho	5352	17	-	-	NNS
cord-006229-7yoilsho	5352	18	sections	section	NNS
cord-006229-7yoilsho	5352	19	.	.	.
cord-006229-7yoilsho	5353	1	The	the	DT
cord-006229-7yoilsho	5353	2	practical	practical	JJ
cord-006229-7yoilsho	5353	3	part	part	NN
cord-006229-7yoilsho	5353	4	consists	consist	VBZ
cord-006229-7yoilsho	5353	5	of	of	IN
cord-006229-7yoilsho	5353	6	twelve	twelve	CD
cord-006229-7yoilsho	5353	7	times	time	NNS
cord-006229-7yoilsho	5353	8	three	three	CD
cord-006229-7yoilsho	5353	9	or	or	CC
cord-006229-7yoilsho	5353	10	four	four	CD
cord-006229-7yoilsho	5353	11	proposals	proposal	NNS
cord-006229-7yoilsho	5353	12	for	for	IN
cord-006229-7yoilsho	5353	13	practical	practical	JJ
cord-006229-7yoilsho	5353	14	tasks	task	NNS
cord-006229-7yoilsho	5353	15	which	which	WDT
cord-006229-7yoilsho	5353	16	are	be	VBP
cord-006229-7yoilsho	5353	17	related	relate	VBN
cord-006229-7yoilsho	5353	18	to	to	IN
cord-006229-7yoilsho	5353	19	the	the	DT
cord-006229-7yoilsho	5353	20	theoretical	theoretical	JJ
cord-006229-7yoilsho	5353	21	lectures	lecture	NNS
cord-006229-7yoilsho	5353	22	.	.	.
cord-006229-7yoilsho	5354	1	Since	since	IN
cord-006229-7yoilsho	5354	2	its	-PRON-	PRP$
cord-006229-7yoilsho	5354	3	launch	launch	NN
cord-006229-7yoilsho	5354	4	in	in	IN
cord-006229-7yoilsho	5354	5	2014	2014	CD
cord-006229-7yoilsho	5354	6	1	1	CD
cord-006229-7yoilsho	5354	7	it	-PRON-	PRP
cord-006229-7yoilsho	5354	8	has	have	VBZ
cord-006229-7yoilsho	5354	9	successfully	successfully	RB
cord-006229-7yoilsho	5354	10	been	be	VBN
cord-006229-7yoilsho	5354	11	used	use	VBN
cord-006229-7yoilsho	5354	12	in	in	IN
cord-006229-7yoilsho	5354	13	several	several	JJ
cord-006229-7yoilsho	5354	14	international	international	JJ
cord-006229-7yoilsho	5354	15	courses	course	NNS
cord-006229-7yoilsho	5354	16	.	.	.
cord-006229-7yoilsho	5355	1	Currently	currently	RB
cord-006229-7yoilsho	5355	2	a	a	DT
cord-006229-7yoilsho	5355	3	pilot	pilot	NN
cord-006229-7yoilsho	5355	4	project	project	NN
cord-006229-7yoilsho	5355	5	is	be	VBZ
cord-006229-7yoilsho	5355	6	under	under	IN
cord-006229-7yoilsho	5355	7	way	way	NN
cord-006229-7yoilsho	5355	8	to	to	TO
cord-006229-7yoilsho	5355	9	explore	explore	VB
cord-006229-7yoilsho	5355	10	its	-PRON-	PRP$
cord-006229-7yoilsho	5355	11	use	use	NN
cord-006229-7yoilsho	5355	12	for	for	IN
cord-006229-7yoilsho	5355	13	'	'	``
cord-006229-7yoilsho	5355	14	crowd	crowd	NN
cord-006229-7yoilsho	5355	15	sourcing	sourcing	NN
cord-006229-7yoilsho	5355	16	'	'	''
cord-006229-7yoilsho	5355	17	:	:	:
cord-006229-7yoilsho	5355	18	it	-PRON-	PRP
cord-006229-7yoilsho	5355	19	is	be	VBZ
cord-006229-7yoilsho	5355	20	placed	place	VBN
cord-006229-7yoilsho	5355	21	on	on	IN
cord-006229-7yoilsho	5355	22	the	the	DT
cord-006229-7yoilsho	5355	23	ISoP	isop	JJ
cord-006229-7yoilsho	5355	24	homepage	homepage	NN
cord-006229-7yoilsho	5355	25	with	with	IN
cord-006229-7yoilsho	5355	26	a	a	DT
cord-006229-7yoilsho	5355	27	programme	programme	NN
cord-006229-7yoilsho	5355	28	allowing	allow	VBG
cord-006229-7yoilsho	5355	29	for	for	IN
cord-006229-7yoilsho	5355	30	institutions	institution	NNS
cord-006229-7yoilsho	5355	31	or	or	CC
cord-006229-7yoilsho	5355	32	persons	person	NNS
cord-006229-7yoilsho	5355	33	experienced	experience	VBN
cord-006229-7yoilsho	5355	34	in	in	IN
cord-006229-7yoilsho	5355	35	PV	pv	NN
cord-006229-7yoilsho	5355	36	teaching	teaching	NN
cord-006229-7yoilsho	5355	37	to	to	TO
cord-006229-7yoilsho	5355	38	upload	upload	VB
cord-006229-7yoilsho	5355	39	any	any	DT
cord-006229-7yoilsho	5355	40	relevant	relevant	JJ
cord-006229-7yoilsho	5355	41	presentations	presentation	NNS
cord-006229-7yoilsho	5355	42	they	-PRON-	PRP
cord-006229-7yoilsho	5355	43	may	may	MD
cord-006229-7yoilsho	5355	44	have	have	VB
cord-006229-7yoilsho	5355	45	with	with	IN
cord-006229-7yoilsho	5355	46	a	a	DT
cord-006229-7yoilsho	5355	47	link	link	NN
cord-006229-7yoilsho	5355	48	to	to	IN
cord-006229-7yoilsho	5355	49	related	related	JJ
cord-006229-7yoilsho	5355	50	chapters	chapter	NNS
cord-006229-7yoilsho	5355	51	,	,	,
cord-006229-7yoilsho	5355	52	sections	section	NNS
cord-006229-7yoilsho	5355	53	or	or	CC
cord-006229-7yoilsho	5355	54	subsections	subsection	NNS
cord-006229-7yoilsho	5355	55	.	.	.
cord-006229-7yoilsho	5356	1	These	these	DT
cord-006229-7yoilsho	5356	2	presentations	presentation	NNS
cord-006229-7yoilsho	5356	3	will	will	MD
cord-006229-7yoilsho	5356	4	be	be	VB
cord-006229-7yoilsho	5356	5	offered	offer	VBN
cord-006229-7yoilsho	5356	6	for	for	IN
cord-006229-7yoilsho	5356	7	downloading	download	VBG
cord-006229-7yoilsho	5356	8	by	by	IN
cord-006229-7yoilsho	5356	9	interested	interested	JJ
cord-006229-7yoilsho	5356	10	users	user	NNS
cord-006229-7yoilsho	5356	11	.	.	.
cord-006229-7yoilsho	5357	1	The	the	DT
cord-006229-7yoilsho	5357	2	curriculum	curriculum	NN
cord-006229-7yoilsho	5357	3	provides	provide	VBZ
cord-006229-7yoilsho	5357	4	a	a	DT
cord-006229-7yoilsho	5357	5	comprehensive	comprehensive	JJ
cord-006229-7yoilsho	5357	6	coverage	coverage	NN
cord-006229-7yoilsho	5357	7	of	of	IN
cord-006229-7yoilsho	5357	8	almost	almost	RB
cord-006229-7yoilsho	5357	9	all	all	DT
cord-006229-7yoilsho	5357	10	areas	area	NNS
cord-006229-7yoilsho	5357	11	of	of	IN
cord-006229-7yoilsho	5357	12	PV	pv	NN
cord-006229-7yoilsho	5357	13	.	.	.
cord-006229-7yoilsho	5358	1	The	the	DT
cord-006229-7yoilsho	5358	2	structure	structure	NN
cord-006229-7yoilsho	5358	3	and	and	CC
cord-006229-7yoilsho	5358	4	content	content	NN
cord-006229-7yoilsho	5358	5	allows	allow	VBZ
cord-006229-7yoilsho	5358	6	almost	almost	RB
cord-006229-7yoilsho	5358	7	every	every	DT
cord-006229-7yoilsho	5358	8	kind	kind	NN
cord-006229-7yoilsho	5358	9	of	of	IN
cord-006229-7yoilsho	5358	10	focusing	focus	VBG
cord-006229-7yoilsho	5358	11	on	on	IN
cord-006229-7yoilsho	5358	12	specific	specific	JJ
cord-006229-7yoilsho	5358	13	issues	issue	NNS
cord-006229-7yoilsho	5358	14	and	and	CC
cord-006229-7yoilsho	5358	15	going	go	VBG
cord-006229-7yoilsho	5358	16	into	into	IN
cord-006229-7yoilsho	5358	17	depth	depth	NN
cord-006229-7yoilsho	5358	18	,	,	,
cord-006229-7yoilsho	5358	19	while	while	IN
cord-006229-7yoilsho	5358	20	maintaining	maintain	VBG
cord-006229-7yoilsho	5358	21	the	the	DT
cord-006229-7yoilsho	5358	22	overall	overall	JJ
cord-006229-7yoilsho	5358	23	context	context	NN
cord-006229-7yoilsho	5358	24	.	.	.
cord-006229-7yoilsho	5359	1	It	-PRON-	PRP
cord-006229-7yoilsho	5359	2	offers	offer	VBZ
cord-006229-7yoilsho	5359	3	opportunities	opportunity	NNS
cord-006229-7yoilsho	5359	4	of	of	IN
cord-006229-7yoilsho	5359	5	tailoring	tailor	VBG
cord-006229-7yoilsho	5359	6	courses	course	NNS
cord-006229-7yoilsho	5359	7	specifically	specifically	RB
cord-006229-7yoilsho	5359	8	to	to	IN
cord-006229-7yoilsho	5359	9	the	the	DT
cord-006229-7yoilsho	5359	10	needs	need	NNS
cord-006229-7yoilsho	5359	11	of	of	IN
cord-006229-7yoilsho	5359	12	different	different	JJ
cord-006229-7yoilsho	5359	13	audiences	audience	NNS
cord-006229-7yoilsho	5359	14	and	and	CC
cord-006229-7yoilsho	5359	15	can	can	MD
cord-006229-7yoilsho	5359	16	be	be	VB
cord-006229-7yoilsho	5359	17	applied	apply	VBN
cord-006229-7yoilsho	5359	18	to	to	IN
cord-006229-7yoilsho	5359	19	various	various	JJ
cord-006229-7yoilsho	5359	20	forms	form	NNS
cord-006229-7yoilsho	5359	21	of	of	IN
cord-006229-7yoilsho	5359	22	training	training	NN
cord-006229-7yoilsho	5359	23	,	,	,
cord-006229-7yoilsho	5359	24	such	such	JJ
cord-006229-7yoilsho	5359	25	as	as	IN
cord-006229-7yoilsho	5359	26	broad	broad	JJ
cord-006229-7yoilsho	5359	27	,	,	,
cord-006229-7yoilsho	5359	28	comprehensive	comprehensive	JJ
cord-006229-7yoilsho	5359	29	and	and	CC
cord-006229-7yoilsho	5359	30	intensive	intensive	JJ
cord-006229-7yoilsho	5359	31	courses	course	NNS
cord-006229-7yoilsho	5359	32	,	,	,
cord-006229-7yoilsho	5359	33	short	short	JJ
cord-006229-7yoilsho	5359	34	overviews	overview	NNS
cord-006229-7yoilsho	5359	35	or	or	CC
cord-006229-7yoilsho	5359	36	focuses	focus	VBZ
cord-006229-7yoilsho	5359	37	on	on	IN
cord-006229-7yoilsho	5359	38	specific	specific	JJ
cord-006229-7yoilsho	5359	39	narrow	narrow	JJ
cord-006229-7yoilsho	5359	40	topics	topic	NNS
cord-006229-7yoilsho	5359	41	in	in	IN
cord-006229-7yoilsho	5359	42	perspective	perspective	NN
cord-006229-7yoilsho	5359	43	.	.	.
cord-006229-7yoilsho	5360	1	According	accord	VBG
cord-006229-7yoilsho	5360	2	to	to	IN
cord-006229-7yoilsho	5360	3	the	the	DT
cord-006229-7yoilsho	5360	4	REACH	reach	NN
cord-006229-7yoilsho	5360	5	Regulation	Regulation	NNP
cord-006229-7yoilsho	5360	6	(	(	-LRB-
cord-006229-7yoilsho	5360	7	EC	EC	NNP
cord-006229-7yoilsho	5360	8	)	)	-RRB-
cord-006229-7yoilsho	5361	1	No	no	UH
cord-006229-7yoilsho	5361	2	.	.	.
cord-006229-7yoilsho	5362	1	1907/2006	1907/2006	CD
cord-006229-7yoilsho	5362	2	chemicals	chemical	NNS
cord-006229-7yoilsho	5362	3	produced	produce	VBN
cord-006229-7yoilsho	5362	4	,	,	,
cord-006229-7yoilsho	5362	5	marketed	market	VBN
cord-006229-7yoilsho	5362	6	or	or	CC
cord-006229-7yoilsho	5362	7	used	use	VBN
cord-006229-7yoilsho	5362	8	within	within	IN
cord-006229-7yoilsho	5362	9	the	the	DT
cord-006229-7yoilsho	5362	10	European	European	NNP
cord-006229-7yoilsho	5362	11	Union	Union	NNP
cord-006229-7yoilsho	5362	12	have	have	VBP
cord-006229-7yoilsho	5362	13	to	to	TO
cord-006229-7yoilsho	5362	14	undergo	undergo	VB
cord-006229-7yoilsho	5362	15	a	a	DT
cord-006229-7yoilsho	5362	16	registration	registration	NN
cord-006229-7yoilsho	5362	17	process	process	NN
cord-006229-7yoilsho	5362	18	,	,	,
cord-006229-7yoilsho	5362	19	wherein	wherein	WRB
cord-006229-7yoilsho	5362	20	the	the	DT
cord-006229-7yoilsho	5362	21	registrants	registrant	NNS
cord-006229-7yoilsho	5362	22	have	have	VBP
cord-006229-7yoilsho	5362	23	to	to	TO
cord-006229-7yoilsho	5362	24	provide	provide	VB
cord-006229-7yoilsho	5362	25	information	information	NN
cord-006229-7yoilsho	5362	26	on	on	IN
cord-006229-7yoilsho	5362	27	hazard	hazard	NN
cord-006229-7yoilsho	5362	28	and	and	CC
cord-006229-7yoilsho	5362	29	potential	potential	JJ
cord-006229-7yoilsho	5362	30	risks	risk	NNS
cord-006229-7yoilsho	5362	31	presented	present	VBN
cord-006229-7yoilsho	5362	32	by	by	IN
cord-006229-7yoilsho	5362	33	the	the	DT
cord-006229-7yoilsho	5362	34	substances	substance	NNS
cord-006229-7yoilsho	5362	35	.	.	.
cord-006229-7yoilsho	5363	1	However	however	RB
cord-006229-7yoilsho	5363	2	,	,	,
cord-006229-7yoilsho	5363	3	the	the	DT
cord-006229-7yoilsho	5363	4	standard	standard	JJ
cord-006229-7yoilsho	5363	5	information	information	NN
cord-006229-7yoilsho	5363	6	requirements	requirement	NNS
cord-006229-7yoilsho	5363	7	defined	define	VBN
cord-006229-7yoilsho	5363	8	in	in	IN
cord-006229-7yoilsho	5363	9	Annexes	Annexes	NNP
cord-006229-7yoilsho	5363	10	VII	VII	NNP
cord-006229-7yoilsho	5363	11	to	to	IN
cord-006229-7yoilsho	5363	12	X	x	NN
cord-006229-7yoilsho	5363	13	of	of	IN
cord-006229-7yoilsho	5363	14	the	the	DT
cord-006229-7yoilsho	5363	15	regulation	regulation	NN
cord-006229-7yoilsho	5363	16	might	may	MD
cord-006229-7yoilsho	5363	17	be	be	VB
cord-006229-7yoilsho	5363	18	waived	waive	VBN
cord-006229-7yoilsho	5363	19	or	or	CC
cord-006229-7yoilsho	5363	20	adapted	adapt	VBN
cord-006229-7yoilsho	5363	21	by	by	IN
cord-006229-7yoilsho	5363	22	the	the	DT
cord-006229-7yoilsho	5363	23	registrants	registrant	NNS
cord-006229-7yoilsho	5363	24	if	if	IN
cord-006229-7yoilsho	5363	25	adequate	adequate	JJ
cord-006229-7yoilsho	5363	26	documentation	documentation	NN
cord-006229-7yoilsho	5363	27	and	and	CC
cord-006229-7yoilsho	5363	28	justification	justification	NN
cord-006229-7yoilsho	5363	29	according	accord	VBG
cord-006229-7yoilsho	5363	30	to	to	IN
cord-006229-7yoilsho	5363	31	criteria	criterion	NNS
cord-006229-7yoilsho	5363	32	specified	specify	VBN
cord-006229-7yoilsho	5363	33	in	in	IN
cord-006229-7yoilsho	5363	34	Annexes	Annexes	NNP
cord-006229-7yoilsho	5363	35	VII	VII	NNP
cord-006229-7yoilsho	5363	36	to	to	IN
cord-006229-7yoilsho	5363	37	XI	XI	NNP
cord-006229-7yoilsho	5363	38	are	be	VBP
cord-006229-7yoilsho	5363	39	provided	provide	VBN
cord-006229-7yoilsho	5363	40	.	.	.
cord-006229-7yoilsho	5364	1	To	to	TO
cord-006229-7yoilsho	5364	2	evaluate	evaluate	VB
cord-006229-7yoilsho	5364	3	the	the	DT
cord-006229-7yoilsho	5364	4	data	datum	NNS
cord-006229-7yoilsho	5364	5	availability	availability	NN
cord-006229-7yoilsho	5364	6	in	in	IN
cord-006229-7yoilsho	5364	7	registration	registration	NN
cord-006229-7yoilsho	5364	8	dossiers	dossier	NNS
cord-006229-7yoilsho	5364	9	of	of	IN
cord-006229-7yoilsho	5364	10	high	high	JJ
cord-006229-7yoilsho	5364	11	tonnage	tonnage	NN
cord-006229-7yoilsho	5364	12	substances	substance	NNS
cord-006229-7yoilsho	5364	13	(	(	-LRB-
cord-006229-7yoilsho	5364	14	above	above	IN
cord-006229-7yoilsho	5364	15	1000	1000	CD
cord-006229-7yoilsho	5364	16	tpa	tpa	NNP
cord-006229-7yoilsho	5364	17	)	)	-RRB-
cord-006229-7yoilsho	5364	18	and	and	CC
cord-006229-7yoilsho	5364	19	their	-PRON-	PRP$
cord-006229-7yoilsho	5364	20	compliance	compliance	NN
cord-006229-7yoilsho	5364	21	with	with	IN
cord-006229-7yoilsho	5364	22	the	the	DT
cord-006229-7yoilsho	5364	23	REACH	REACH	NNP
cord-006229-7yoilsho	5364	24	Regulation	Regulation	NNP
cord-006229-7yoilsho	5364	25	,	,	,
cord-006229-7yoilsho	5364	26	the	the	DT
cord-006229-7yoilsho	5364	27	Federal	Federal	NNP
cord-006229-7yoilsho	5364	28	Institute	Institute	NNP
cord-006229-7yoilsho	5364	29	for	for	IN
cord-006229-7yoilsho	5364	30	Risk	Risk	NNP
cord-006229-7yoilsho	5364	31	Assessment	Assessment	NNP
cord-006229-7yoilsho	5364	32	(	(	-LRB-
cord-006229-7yoilsho	5364	33	BfR	BfR	NNP
cord-006229-7yoilsho	5364	34	)	)	-RRB-
cord-006229-7yoilsho	5364	35	in	in	IN
cord-006229-7yoilsho	5364	36	cooperation	cooperation	NN
cord-006229-7yoilsho	5364	37	with	with	IN
cord-006229-7yoilsho	5364	38	the	the	DT
cord-006229-7yoilsho	5364	39	Federal	Federal	NNP
cord-006229-7yoilsho	5364	40	Environment	Environment	NNP
cord-006229-7yoilsho	5364	41	Agency	Agency	NNP
cord-006229-7yoilsho	5364	42	(	(	-LRB-
cord-006229-7yoilsho	5364	43	UBA	UBA	NNP
cord-006229-7yoilsho	5364	44	)	)	-RRB-
cord-006229-7yoilsho	5364	45	developed	develop	VBD
cord-006229-7yoilsho	5364	46	a	a	DT
cord-006229-7yoilsho	5364	47	systematic	systematic	JJ
cord-006229-7yoilsho	5364	48	web	web	NN
cord-006229-7yoilsho	5364	49	-	-	HYPH
cord-006229-7yoilsho	5364	50	based	base	VBN
cord-006229-7yoilsho	5364	51	scheme	scheme	NN
cord-006229-7yoilsho	5364	52	.	.	.
cord-006229-7yoilsho	5365	1	In	in	IN
cord-006229-7yoilsho	5365	2	total	total	JJ
cord-006229-7yoilsho	5365	3	,	,	,
cord-006229-7yoilsho	5365	4	1932	1932	CD
cord-006229-7yoilsho	5365	5	dossiers	dossier	NNS
cord-006229-7yoilsho	5365	6	were	be	VBD
cord-006229-7yoilsho	5365	7	checked	check	VBN
cord-006229-7yoilsho	5365	8	for	for	IN
cord-006229-7yoilsho	5365	9	selected	select	VBN
cord-006229-7yoilsho	5365	10	human	human	JJ
cord-006229-7yoilsho	5365	11	health	health	NN
cord-006229-7yoilsho	5365	12	and	and	CC
cord-006229-7yoilsho	5365	13	environmental	environmental	JJ
cord-006229-7yoilsho	5365	14	endpoints	endpoint	NNS
cord-006229-7yoilsho	5365	15	such	such	JJ
cord-006229-7yoilsho	5365	16	as	as	IN
cord-006229-7yoilsho	5365	17	repeated	repeat	VBN
cord-006229-7yoilsho	5365	18	dose	dose	JJ
cord-006229-7yoilsho	5365	19	toxicity	toxicity	NN
cord-006229-7yoilsho	5365	20	,	,	,
cord-006229-7yoilsho	5365	21	genetic	genetic	JJ
cord-006229-7yoilsho	5365	22	toxicity	toxicity	NN
cord-006229-7yoilsho	5365	23	and	and	CC
cord-006229-7yoilsho	5365	24	ecotoxicity	ecotoxicity	NN
cord-006229-7yoilsho	5365	25	.	.	.
cord-006229-7yoilsho	5366	1	A	a	DT
cord-006229-7yoilsho	5366	2	remarkable	remarkable	JJ
cord-006229-7yoilsho	5366	3	high	high	JJ
cord-006229-7yoilsho	5366	4	rate	rate	NN
cord-006229-7yoilsho	5366	5	,	,	,
cord-006229-7yoilsho	5366	6	43	43	CD
cord-006229-7yoilsho	5366	7	%	%	NN
cord-006229-7yoilsho	5366	8	to	to	IN
cord-006229-7yoilsho	5366	9	82	82	CD
cord-006229-7yoilsho	5366	10	%	%	NN
cord-006229-7yoilsho	5366	11	depending	depend	VBG
cord-006229-7yoilsho	5366	12	on	on	IN
cord-006229-7yoilsho	5366	13	the	the	DT
cord-006229-7yoilsho	5366	14	endpoint	endpoint	NN
cord-006229-7yoilsho	5366	15	,	,	,
cord-006229-7yoilsho	5366	16	of	of	IN
cord-006229-7yoilsho	5366	17	the	the	DT
cord-006229-7yoilsho	5366	18	evaluated	evaluate	VBN
cord-006229-7yoilsho	5366	19	dossiers	dossier	NNS
cord-006229-7yoilsho	5366	20	included	include	VBD
cord-006229-7yoilsho	5366	21	waiving	waive	VBG
cord-006229-7yoilsho	5366	22	or	or	CC
cord-006229-7yoilsho	5366	23	adaptations	adaptation	NNS
cord-006229-7yoilsho	5366	24	from	from	IN
cord-006229-7yoilsho	5366	25	the	the	DT
cord-006229-7yoilsho	5366	26	standard	standard	JJ
cord-006229-7yoilsho	5366	27	information	information	NN
cord-006229-7yoilsho	5366	28	requirements	requirement	NNS
cord-006229-7yoilsho	5366	29	.	.	.
cord-006229-7yoilsho	5367	1	Therefore	therefore	RB
cord-006229-7yoilsho	5367	2	,	,	,
cord-006229-7yoilsho	5367	3	those	those	DT
cord-006229-7yoilsho	5367	4	dossiers	dossier	NNS
cord-006229-7yoilsho	5367	5	were	be	VBD
cord-006229-7yoilsho	5367	6	not	not	RB
cord-006229-7yoilsho	5367	7	concluded	conclude	VBN
cord-006229-7yoilsho	5367	8	,	,	,
cord-006229-7yoilsho	5367	9	but	but	CC
cord-006229-7yoilsho	5367	10	categorised	categorise	VBN
cord-006229-7yoilsho	5367	11	as	as	IN
cord-006229-7yoilsho	5367	12	'	'	``
cord-006229-7yoilsho	5367	13	complex	complex	JJ
cord-006229-7yoilsho	5367	14	'	'	''
cord-006229-7yoilsho	5367	15	(	(	-LRB-
cord-006229-7yoilsho	5367	16	Springer	Springer	NNP
cord-006229-7yoilsho	5367	17	et	et	FW
cord-006229-7yoilsho	5367	18	al	al	NNP
cord-006229-7yoilsho	5367	19	.	.	NNP
cord-006229-7yoilsho	5367	20	,	,	,
cord-006229-7yoilsho	5367	21	2015	2015	CD
cord-006229-7yoilsho	5367	22	)	)	-RRB-
cord-006229-7yoilsho	5367	23	.	.	.
cord-006229-7yoilsho	5368	1	The	the	DT
cord-006229-7yoilsho	5368	2	use	use	NN
cord-006229-7yoilsho	5368	3	of	of	IN
cord-006229-7yoilsho	5368	4	waiving	waiving	NN
cord-006229-7yoilsho	5368	5	and	and	CC
cord-006229-7yoilsho	5368	6	adaptations	adaptation	NNS
cord-006229-7yoilsho	5368	7	in	in	IN
cord-006229-7yoilsho	5368	8	'	'	``
cord-006229-7yoilsho	5368	9	complex	complex	JJ
cord-006229-7yoilsho	5368	10	'	'	''
cord-006229-7yoilsho	5368	11	endpoints	endpoint	NNS
cord-006229-7yoilsho	5368	12	were	be	VBD
cord-006229-7yoilsho	5368	13	part	part	NN
cord-006229-7yoilsho	5368	14	of	of	IN
cord-006229-7yoilsho	5368	15	a	a	DT
cord-006229-7yoilsho	5368	16	follow	follow	VB
cord-006229-7yoilsho	5368	17	-	-	HYPH
cord-006229-7yoilsho	5368	18	up	up	NN
cord-006229-7yoilsho	5368	19	project	project	NN
cord-006229-7yoilsho	5368	20	.	.	.
cord-006229-7yoilsho	5369	1	Herein	herein	RB
cord-006229-7yoilsho	5369	2	,	,	,
cord-006229-7yoilsho	5369	3	it	-PRON-	PRP
cord-006229-7yoilsho	5369	4	was	be	VBD
cord-006229-7yoilsho	5369	5	evaluated	evaluate	VBN
cord-006229-7yoilsho	5369	6	whether	whether	IN
cord-006229-7yoilsho	5369	7	the	the	DT
cord-006229-7yoilsho	5369	8	given	give	VBN
cord-006229-7yoilsho	5369	9	justifications	justification	NNS
cord-006229-7yoilsho	5369	10	were	be	VBD
cord-006229-7yoilsho	5369	11	in	in	IN
cord-006229-7yoilsho	5369	12	accordance	accordance	NN
cord-006229-7yoilsho	5369	13	with	with	IN
cord-006229-7yoilsho	5369	14	the	the	DT
cord-006229-7yoilsho	5369	15	criteria	criterion	NNS
cord-006229-7yoilsho	5369	16	set	set	VBN
cord-006229-7yoilsho	5369	17	out	out	RP
cord-006229-7yoilsho	5369	18	in	in	IN
cord-006229-7yoilsho	5369	19	the	the	DT
cord-006229-7yoilsho	5369	20	respective	respective	JJ
cord-006229-7yoilsho	5369	21	REACH	reach	NN
cord-006229-7yoilsho	5369	22	Annexes	Annexes	NNP
cord-006229-7yoilsho	5369	23	.	.	.
cord-006229-7yoilsho	5370	1	The	the	DT
cord-006229-7yoilsho	5370	2	results	result	NNS
cord-006229-7yoilsho	5370	3	will	will	MD
cord-006229-7yoilsho	5370	4	show	show	VB
cord-006229-7yoilsho	5370	5	the	the	DT
cord-006229-7yoilsho	5370	6	frequency	frequency	NN
cord-006229-7yoilsho	5370	7	and	and	CC
cord-006229-7yoilsho	5370	8	pattern	pattern	NN
cord-006229-7yoilsho	5370	9	of	of	IN
cord-006229-7yoilsho	5370	10	waiving	waive	VBG
cord-006229-7yoilsho	5370	11	/	/	SYM
cord-006229-7yoilsho	5370	12	adaptation	adaptation	NN
cord-006229-7yoilsho	5370	13	approaches	approach	NNS
cord-006229-7yoilsho	5370	14	for	for	IN
cord-006229-7yoilsho	5370	15	the	the	DT
cord-006229-7yoilsho	5370	16	human	human	JJ
cord-006229-7yoilsho	5370	17	health	health	NN
cord-006229-7yoilsho	5370	18	as	as	RB
cord-006229-7yoilsho	5370	19	well	well	RB
cord-006229-7yoilsho	5370	20	as	as	IN
cord-006229-7yoilsho	5370	21	the	the	DT
cord-006229-7yoilsho	5370	22	environmental	environmental	JJ
cord-006229-7yoilsho	5370	23	endpoints	endpoint	NNS
cord-006229-7yoilsho	5370	24	.	.	.
cord-006229-7yoilsho	5371	1	Besides	besides	IN
cord-006229-7yoilsho	5371	2	this	this	DT
cord-006229-7yoilsho	5371	3	general	general	JJ
cord-006229-7yoilsho	5371	4	overview	overview	NN
cord-006229-7yoilsho	5371	5	,	,	,
cord-006229-7yoilsho	5371	6	specific	specific	JJ
cord-006229-7yoilsho	5371	7	problems	problem	NNS
cord-006229-7yoilsho	5371	8	regarding	regard	VBG
cord-006229-7yoilsho	5371	9	the	the	DT
cord-006229-7yoilsho	5371	10	application	application	NN
cord-006229-7yoilsho	5371	11	of	of	IN
cord-006229-7yoilsho	5371	12	the	the	DT
cord-006229-7yoilsho	5371	13	REACH	REACH	NNP
cord-006229-7yoilsho	5371	14	Regulation	Regulation	NNP
cord-006229-7yoilsho	5371	15	were	be	VBD
cord-006229-7yoilsho	5371	16	identified	identify	VBN
cord-006229-7yoilsho	5371	17	and	and	CC
cord-006229-7yoilsho	5371	18	their	-PRON-	PRP$
cord-006229-7yoilsho	5371	19	significance	significance	NN
cord-006229-7yoilsho	5371	20	with	with	IN
cord-006229-7yoilsho	5371	21	regard	regard	NN
cord-006229-7yoilsho	5371	22	to	to	IN
cord-006229-7yoilsho	5371	23	remaining	remain	VBG
cord-006229-7yoilsho	5371	24	data	datum	NNS
cord-006229-7yoilsho	5371	25	gaps	gap	NNS
cord-006229-7yoilsho	5371	26	will	will	MD
cord-006229-7yoilsho	5371	27	be	be	VB
cord-006229-7yoilsho	5371	28	discussed	discuss	VBN
cord-006229-7yoilsho	5371	29	.	.	.
cord-006229-7yoilsho	5372	1	The	the	DT
cord-006229-7yoilsho	5372	2	German	German	NNP
cord-006229-7yoilsho	5372	3	Commission	Commission	NNP
cord-006229-7yoilsho	5372	4	for	for	IN
cord-006229-7yoilsho	5372	5	the	the	DT
cord-006229-7yoilsho	5372	6	Investigation	Investigation	NNP
cord-006229-7yoilsho	5372	7	of	of	IN
cord-006229-7yoilsho	5372	8	Health	Health	NNP
cord-006229-7yoilsho	5372	9	Hazards	Hazards	NNPS
cord-006229-7yoilsho	5372	10	of	of	IN
cord-006229-7yoilsho	5372	11	Chemical	Chemical	NNP
cord-006229-7yoilsho	5372	12	Compounds	Compounds	NNPS
cord-006229-7yoilsho	5372	13	in	in	IN
cord-006229-7yoilsho	5372	14	the	the	DT
cord-006229-7yoilsho	5372	15	Work	Work	NNP
cord-006229-7yoilsho	5372	16	Area	Area	NNP
cord-006229-7yoilsho	5372	17	has	have	VBZ
cord-006229-7yoilsho	5372	18	re	re	VBN
cord-006229-7yoilsho	5372	19	-	-	VBN
cord-006229-7yoilsho	5372	20	evaluated	evaluate	VBN
cord-006229-7yoilsho	5372	21	dimethylformamide	dimethylformamide	NN
cord-006229-7yoilsho	5372	22	,	,	,
cord-006229-7yoilsho	5372	23	and	and	CC
cord-006229-7yoilsho	5372	24	classified	classify	VBD
cord-006229-7yoilsho	5372	25	it	-PRON-	PRP
cord-006229-7yoilsho	5372	26	in	in	IN
cord-006229-7yoilsho	5372	27	the	the	DT
cord-006229-7yoilsho	5372	28	Carcinogen	Carcinogen	NNP
cord-006229-7yoilsho	5372	29	Category	Category	NNP
cord-006229-7yoilsho	5372	30	4	4	CD
cord-006229-7yoilsho	5372	31	.	.	.
cord-006229-7yoilsho	5373	1	This	this	DT
cord-006229-7yoilsho	5373	2	category	category	NN
cord-006229-7yoilsho	5373	3	is	be	VBZ
cord-006229-7yoilsho	5373	4	for	for	IN
cord-006229-7yoilsho	5373	5	chemicals	chemical	NNS
cord-006229-7yoilsho	5373	6	with	with	IN
cord-006229-7yoilsho	5373	7	carcinogenic	carcinogenic	JJ
cord-006229-7yoilsho	5373	8	potential	potential	NN
cord-006229-7yoilsho	5373	9	for	for	IN
cord-006229-7yoilsho	5373	10	which	which	WDT
cord-006229-7yoilsho	5373	11	a	a	DT
cord-006229-7yoilsho	5373	12	non	non	JJ
cord-006229-7yoilsho	5373	13	-	-	JJ
cord-006229-7yoilsho	5373	14	genotoxic	genotoxic	JJ
cord-006229-7yoilsho	5373	15	mode	mode	NN
cord-006229-7yoilsho	5373	16	of	of	IN
cord-006229-7yoilsho	5373	17	action	action	NN
cord-006229-7yoilsho	5373	18	is	be	VBZ
cord-006229-7yoilsho	5373	19	of	of	IN
cord-006229-7yoilsho	5373	20	prime	prime	JJ
cord-006229-7yoilsho	5373	21	importance	importance	NN
cord-006229-7yoilsho	5373	22	and	and	CC
cord-006229-7yoilsho	5373	23	genotoxic	genotoxic	JJ
cord-006229-7yoilsho	5373	24	effects	effect	NNS
cord-006229-7yoilsho	5373	25	play	play	VBP
cord-006229-7yoilsho	5373	26	no	no	NN
cord-006229-7yoilsho	5373	27	or	or	CC
cord-006229-7yoilsho	5373	28	at	at	IN
cord-006229-7yoilsho	5373	29	most	most	JJS
cord-006229-7yoilsho	5373	30	a	a	DT
cord-006229-7yoilsho	5373	31	minor	minor	JJ
cord-006229-7yoilsho	5373	32	part	part	NN
cord-006229-7yoilsho	5373	33	provided	provide	VBD
cord-006229-7yoilsho	5373	34	the	the	DT
cord-006229-7yoilsho	5373	35	MAK	MAK	NNP
cord-006229-7yoilsho	5373	36	and	and	CC
cord-006229-7yoilsho	5373	37	BAT	bat	NN
cord-006229-7yoilsho	5373	38	values	value	NNS
cord-006229-7yoilsho	5373	39	are	be	VBP
cord-006229-7yoilsho	5373	40	observed	observe	VBN
cord-006229-7yoilsho	5373	41	.	.	.
cord-006229-7yoilsho	5374	1	Under	under	IN
cord-006229-7yoilsho	5374	2	these	these	DT
cord-006229-7yoilsho	5374	3	conditions	condition	NNS
cord-006229-7yoilsho	5374	4	no	no	DT
cord-006229-7yoilsho	5374	5	contribution	contribution	NN
cord-006229-7yoilsho	5374	6	to	to	IN
cord-006229-7yoilsho	5374	7	human	human	JJ
cord-006229-7yoilsho	5374	8	cancer	cancer	NN
cord-006229-7yoilsho	5374	9	risk	risk	NN
cord-006229-7yoilsho	5374	10	is	be	VBZ
cord-006229-7yoilsho	5374	11	expected	expect	VBN
cord-006229-7yoilsho	5374	12	.	.	.
cord-006229-7yoilsho	5375	1	DMF	DMF	NNP
cord-006229-7yoilsho	5375	2	was	be	VBD
cord-006229-7yoilsho	5375	3	identified	identify	VBN
cord-006229-7yoilsho	5375	4	as	as	IN
cord-006229-7yoilsho	5375	5	a	a	DT
cord-006229-7yoilsho	5375	6	Substance	substance	NN
cord-006229-7yoilsho	5375	7	of	of	IN
cord-006229-7yoilsho	5375	8	Very	very	RB
cord-006229-7yoilsho	5375	9	High	high	JJ
cord-006229-7yoilsho	5375	10	Concern	concern	NN
cord-006229-7yoilsho	5375	11	by	by	IN
cord-006229-7yoilsho	5375	12	European	European	NNP
cord-006229-7yoilsho	5375	13	Commission	Commission	NNP
cord-006229-7yoilsho	5375	14	.	.	.
cord-006229-7yoilsho	5376	1	The	the	DT
cord-006229-7yoilsho	5376	2	amount	amount	NN
cord-006229-7yoilsho	5376	3	of	of	IN
cord-006229-7yoilsho	5376	4	DMF	DMF	NNP
cord-006229-7yoilsho	5376	5	manufactured	manufacture	VBN
cord-006229-7yoilsho	5376	6	and/or	and/or	CC
cord-006229-7yoilsho	5376	7	imported	import	VBN
cord-006229-7yoilsho	5376	8	into	into	IN
cord-006229-7yoilsho	5376	9	the	the	DT
cord-006229-7yoilsho	5376	10	EU	EU	NNP
cord-006229-7yoilsho	5376	11	is	be	VBZ
cord-006229-7yoilsho	5376	12	,	,	,
cord-006229-7yoilsho	5376	13	in	in	IN
cord-006229-7yoilsho	5376	14	the	the	DT
cord-006229-7yoilsho	5376	15	range	range	NN
cord-006229-7yoilsho	5376	16	of	of	IN
cord-006229-7yoilsho	5376	17	10000	10000	CD
cord-006229-7yoilsho	5376	18	-	-	SYM
cord-006229-7yoilsho	5376	19	100	100	CD
cord-006229-7yoilsho	5376	20	000	000	CD
cord-006229-7yoilsho	5376	21	t	t	NN
cord-006229-7yoilsho	5376	22	/	/	SYM
cord-006229-7yoilsho	5376	23	y	y	NNP
cord-006229-7yoilsho	5376	24	.	.	.
cord-006229-7yoilsho	5377	1	N	N	NNP
cord-006229-7yoilsho	5377	2	,	,	,
cord-006229-7yoilsho	5377	3	N	N	NNP
cord-006229-7yoilsho	5377	4	-	-	HYPH
cord-006229-7yoilsho	5377	5	Dimethylformamide	Dimethylformamide	NNP
cord-006229-7yoilsho	5377	6	is	be	VBZ
cord-006229-7yoilsho	5377	7	a	a	DT
cord-006229-7yoilsho	5377	8	hepatotoxin	hepatotoxin	NN
cord-006229-7yoilsho	5377	9	in	in	IN
cord-006229-7yoilsho	5377	10	humans	human	NNS
cord-006229-7yoilsho	5377	11	and	and	CC
cord-006229-7yoilsho	5377	12	rats	rat	NNS
cord-006229-7yoilsho	5377	13	.	.	.
cord-006229-7yoilsho	5378	1	The	the	DT
cord-006229-7yoilsho	5378	2	carcinogenicity	carcinogenicity	NN
cord-006229-7yoilsho	5378	3	studies	study	NNS
cord-006229-7yoilsho	5378	4	in	in	IN
cord-006229-7yoilsho	5378	5	both	both	DT
cord-006229-7yoilsho	5378	6	mouse	mouse	NN
cord-006229-7yoilsho	5378	7	and	and	CC
cord-006229-7yoilsho	5378	8	rat	rat	NN
cord-006229-7yoilsho	5378	9	were	be	VBD
cord-006229-7yoilsho	5378	10	conducted	conduct	VBN
cord-006229-7yoilsho	5378	11	with	with	IN
cord-006229-7yoilsho	5378	12	test	test	NN
cord-006229-7yoilsho	5378	13	material	material	NN
cord-006229-7yoilsho	5378	14	of	of	IN
cord-006229-7yoilsho	5378	15	an	an	DT
cord-006229-7yoilsho	5378	16	acceptable	acceptable	JJ
cord-006229-7yoilsho	5378	17	purity	purity	NN
cord-006229-7yoilsho	5378	18	and	and	CC
cord-006229-7yoilsho	5378	19	physical	physical	JJ
cord-006229-7yoilsho	5378	20	form	form	NN
cord-006229-7yoilsho	5378	21	.	.	.
cord-006229-7yoilsho	5379	1	The	the	DT
cord-006229-7yoilsho	5379	2	critical	critical	JJ
cord-006229-7yoilsho	5379	3	study	study	NN
cord-006229-7yoilsho	5379	4	involved	involve	VBD
cord-006229-7yoilsho	5379	5	administration	administration	NN
cord-006229-7yoilsho	5379	6	of	of	IN
cord-006229-7yoilsho	5379	7	DMF	DMF	NNP
cord-006229-7yoilsho	5379	8	via	via	IN
cord-006229-7yoilsho	5379	9	inhalation	inhalation	NN
cord-006229-7yoilsho	5379	10	,	,	,
cord-006229-7yoilsho	5379	11	which	which	WDT
cord-006229-7yoilsho	5379	12	is	be	VBZ
cord-006229-7yoilsho	5379	13	relevant	relevant	JJ
cord-006229-7yoilsho	5379	14	to	to	IN
cord-006229-7yoilsho	5379	15	human	human	JJ
cord-006229-7yoilsho	5379	16	exposure	exposure	NN
cord-006229-7yoilsho	5379	17	.	.	.
cord-006229-7yoilsho	5380	1	There	there	EX
cord-006229-7yoilsho	5380	2	is	be	VBZ
cord-006229-7yoilsho	5380	3	conclusive	conclusive	JJ
cord-006229-7yoilsho	5380	4	evidence	evidence	NN
cord-006229-7yoilsho	5380	5	that	that	IN
cord-006229-7yoilsho	5380	6	DMF	DMF	NNP
cord-006229-7yoilsho	5380	7	induces	induce	VBZ
cord-006229-7yoilsho	5380	8	significant	significant	JJ
cord-006229-7yoilsho	5380	9	increases	increase	NNS
cord-006229-7yoilsho	5380	10	of	of	IN
cord-006229-7yoilsho	5380	11	hepatocellular	hepatocellular	JJ
cord-006229-7yoilsho	5380	12	carcinomas	carcinoma	NNS
cord-006229-7yoilsho	5380	13	in	in	IN
cord-006229-7yoilsho	5380	14	rats	rat	NNS
cord-006229-7yoilsho	5380	15	after	after	IN
cord-006229-7yoilsho	5380	16	exposure	exposure	NN
cord-006229-7yoilsho	5380	17	to	to	IN
cord-006229-7yoilsho	5380	18	800	800	CD
cord-006229-7yoilsho	5380	19	ml	ml	NN
cord-006229-7yoilsho	5380	20	/	/	SYM
cord-006229-7yoilsho	5380	21	m³	m³	NN
cord-006229-7yoilsho	5380	22	and	and	CC
cord-006229-7yoilsho	5380	23	in	in	IN
cord-006229-7yoilsho	5380	24	mice	mouse	NNS
cord-006229-7yoilsho	5380	25	in	in	IN
cord-006229-7yoilsho	5380	26	response	response	NN
cord-006229-7yoilsho	5380	27	to	to	IN
cord-006229-7yoilsho	5380	28	200	200	CD
cord-006229-7yoilsho	5380	29	ml	ml	NN
cord-006229-7yoilsho	5380	30	/	/	SYM
cord-006229-7yoilsho	5380	31	m³	m³	NN
cord-006229-7yoilsho	5380	32	and	and	CC
cord-006229-7yoilsho	5380	33	higher	high	JJR
cord-006229-7yoilsho	5380	34	.	.	.
cord-006229-7yoilsho	5381	1	Several	several	JJ
cord-006229-7yoilsho	5381	2	in	in	IN
cord-006229-7yoilsho	5381	3	vitro	vitro	FW
cord-006229-7yoilsho	5381	4	and	and	CC
cord-006229-7yoilsho	5381	5	in	in	IN
cord-006229-7yoilsho	5381	6	vivo	vivo	NNP
cord-006229-7yoilsho	5381	7	studies	study	NNS
cord-006229-7yoilsho	5381	8	have	have	VBP
cord-006229-7yoilsho	5381	9	indicated	indicate	VBN
cord-006229-7yoilsho	5381	10	that	that	IN
cord-006229-7yoilsho	5381	11	DMF	DMF	NNP
cord-006229-7yoilsho	5381	12	is	be	VBZ
cord-006229-7yoilsho	5381	13	not	not	RB
cord-006229-7yoilsho	5381	14	genotoxic	genotoxic	JJ
cord-006229-7yoilsho	5381	15	.	.	.
cord-006229-7yoilsho	5382	1	The	the	DT
cord-006229-7yoilsho	5382	2	results	result	NNS
cord-006229-7yoilsho	5382	3	of	of	IN
cord-006229-7yoilsho	5382	4	the	the	DT
cord-006229-7yoilsho	5382	5	long	long	JJ
cord-006229-7yoilsho	5382	6	-	-	HYPH
cord-006229-7yoilsho	5382	7	term	term	NN
cord-006229-7yoilsho	5382	8	studies	study	NNS
cord-006229-7yoilsho	5382	9	reveal	reveal	VBP
cord-006229-7yoilsho	5382	10	that	that	IN
cord-006229-7yoilsho	5382	11	the	the	DT
cord-006229-7yoilsho	5382	12	tumors	tumor	NNS
cord-006229-7yoilsho	5382	13	develop	develop	VBP
cord-006229-7yoilsho	5382	14	in	in	IN
cord-006229-7yoilsho	5382	15	the	the	DT
cord-006229-7yoilsho	5382	16	liver	liver	NN
cord-006229-7yoilsho	5382	17	only	only	RB
cord-006229-7yoilsho	5382	18	after	after	IN
cord-006229-7yoilsho	5382	19	chronic	chronic	JJ
cord-006229-7yoilsho	5382	20	toxic	toxic	JJ
cord-006229-7yoilsho	5382	21	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	5382	22	and	and	CC
cord-006229-7yoilsho	5382	23	degenerative	degenerative	JJ
cord-006229-7yoilsho	5382	24	changes	change	NNS
cord-006229-7yoilsho	5382	25	have	have	VBP
cord-006229-7yoilsho	5382	26	developed	develop	VBN
cord-006229-7yoilsho	5382	27	in	in	IN
cord-006229-7yoilsho	5382	28	this	this	DT
cord-006229-7yoilsho	5382	29	organ	organ	NN
cord-006229-7yoilsho	5382	30	.	.	.
cord-006229-7yoilsho	5383	1	The	the	DT
cord-006229-7yoilsho	5383	2	Commission	Commission	NNP
cord-006229-7yoilsho	5383	3	concluded	conclude	VBD
cord-006229-7yoilsho	5383	4	that	that	IN
cord-006229-7yoilsho	5383	5	the	the	DT
cord-006229-7yoilsho	5383	6	tumors	tumor	NNS
cord-006229-7yoilsho	5383	7	are	be	VBP
cord-006229-7yoilsho	5383	8	a	a	DT
cord-006229-7yoilsho	5383	9	result	result	NN
cord-006229-7yoilsho	5383	10	of	of	IN
cord-006229-7yoilsho	5383	11	chronic	chronic	JJ
cord-006229-7yoilsho	5383	12	liver	liver	NN
cord-006229-7yoilsho	5383	13	damage	damage	NN
cord-006229-7yoilsho	5383	14	,	,	,
cord-006229-7yoilsho	5383	15	occurring	occur	VBG
cord-006229-7yoilsho	5383	16	at	at	IN
cord-006229-7yoilsho	5383	17	high	high	JJ
cord-006229-7yoilsho	5383	18	exposure	exposure	NN
cord-006229-7yoilsho	5383	19	concentrations	concentration	NNS
cord-006229-7yoilsho	5383	20	.	.	.
cord-006229-7yoilsho	5384	1	The	the	DT
cord-006229-7yoilsho	5384	2	available	available	JJ
cord-006229-7yoilsho	5384	3	evidence	evidence	NN
cord-006229-7yoilsho	5384	4	therefore	therefore	RB
cord-006229-7yoilsho	5384	5	suggests	suggest	VBZ
cord-006229-7yoilsho	5384	6	that	that	IN
cord-006229-7yoilsho	5384	7	there	there	EX
cord-006229-7yoilsho	5384	8	is	be	VBZ
cord-006229-7yoilsho	5384	9	a	a	DT
cord-006229-7yoilsho	5384	10	threshold	threshold	NN
cord-006229-7yoilsho	5384	11	dose	dose	NN
cord-006229-7yoilsho	5384	12	for	for	IN
cord-006229-7yoilsho	5384	13	the	the	DT
cord-006229-7yoilsho	5384	14	carcinogenic	carcinogenic	JJ
cord-006229-7yoilsho	5384	15	effects	effect	NNS
cord-006229-7yoilsho	5384	16	of	of	IN
cord-006229-7yoilsho	5384	17	DMF	DMF	NNP
cord-006229-7yoilsho	5384	18	.	.	.
cord-006229-7yoilsho	5385	1	Accordingly	accordingly	RB
cord-006229-7yoilsho	5385	2	,	,	,
cord-006229-7yoilsho	5385	3	DMF	DMF	NNP
cord-006229-7yoilsho	5385	4	was	be	VBD
cord-006229-7yoilsho	5385	5	classified	classify	VBN
cord-006229-7yoilsho	5385	6	in	in	IN
cord-006229-7yoilsho	5385	7	Carcinogen	Carcinogen	NNP
cord-006229-7yoilsho	5385	8	Category	Category	NNP
cord-006229-7yoilsho	5385	9	4	4	CD
cord-006229-7yoilsho	5385	10	with	with	IN
cord-006229-7yoilsho	5385	11	a	a	DT
cord-006229-7yoilsho	5385	12	MAK	MAK	NNP
cord-006229-7yoilsho	5385	13	-	-	HYPH
cord-006229-7yoilsho	5385	14	value	value	NN
cord-006229-7yoilsho	5385	15	of	of	IN
cord-006229-7yoilsho	5385	16	5	5	CD
cord-006229-7yoilsho	5385	17	ml	ml	NN
cord-006229-7yoilsho	5385	18	/	/	SYM
cord-006229-7yoilsho	5385	19	m³	m³	NN
cord-006229-7yoilsho	5385	20	,	,	,
cord-006229-7yoilsho	5385	21	an	an	DT
cord-006229-7yoilsho	5385	22	exposure	exposure	NN
cord-006229-7yoilsho	5385	23	concentration	concentration	NN
cord-006229-7yoilsho	5385	24	which	which	WDT
cord-006229-7yoilsho	5385	25	does	do	VBZ
cord-006229-7yoilsho	5385	26	not	not	RB
cord-006229-7yoilsho	5385	27	induces	induce	VBZ
cord-006229-7yoilsho	5385	28	liver	liver	NN
cord-006229-7yoilsho	5385	29	toxicity	toxicity	NN
cord-006229-7yoilsho	5385	30	and	and	CC
cord-006229-7yoilsho	5385	31	as	as	IN
cord-006229-7yoilsho	5385	32	a	a	DT
cord-006229-7yoilsho	5385	33	consequence	consequence	NN
cord-006229-7yoilsho	5385	34	is	be	VBZ
cord-006229-7yoilsho	5385	35	not	not	RB
cord-006229-7yoilsho	5385	36	associated	associate	VBN
cord-006229-7yoilsho	5385	37	with	with	IN
cord-006229-7yoilsho	5385	38	an	an	DT
cord-006229-7yoilsho	5385	39	increased	increase	VBN
cord-006229-7yoilsho	5385	40	cancer	cancer	NN
cord-006229-7yoilsho	5385	41	risk	risk	NN
cord-006229-7yoilsho	5385	42	.	.	.
cord-006229-7yoilsho	5386	1	Today	today	NN
cord-006229-7yoilsho	5386	2	,	,	,
cord-006229-7yoilsho	5386	3	a	a	DT
cord-006229-7yoilsho	5386	4	large	large	JJ
cord-006229-7yoilsho	5386	5	majority	majority	NN
cord-006229-7yoilsho	5386	6	of	of	IN
cord-006229-7yoilsho	5386	7	people	people	NNS
cord-006229-7yoilsho	5386	8	is	be	VBZ
cord-006229-7yoilsho	5386	9	constantly	constantly	RB
cord-006229-7yoilsho	5386	10	exposed	expose	VBN
cord-006229-7yoilsho	5386	11	to	to	IN
cord-006229-7yoilsho	5386	12	electromagnetic	electromagnetic	JJ
cord-006229-7yoilsho	5386	13	radiation	radiation	NN
cord-006229-7yoilsho	5386	14	.	.	.
cord-006229-7yoilsho	5387	1	Many	many	JJ
cord-006229-7yoilsho	5387	2	studies	study	NNS
cord-006229-7yoilsho	5387	3	have	have	VBP
cord-006229-7yoilsho	5387	4	been	be	VBN
cord-006229-7yoilsho	5387	5	performed	perform	VBN
cord-006229-7yoilsho	5387	6	to	to	TO
cord-006229-7yoilsho	5387	7	investigate	investigate	VB
cord-006229-7yoilsho	5387	8	whether	whether	IN
cord-006229-7yoilsho	5387	9	this	this	DT
cord-006229-7yoilsho	5387	10	type	type	NN
cord-006229-7yoilsho	5387	11	of	of	IN
cord-006229-7yoilsho	5387	12	radiation	radiation	NN
cord-006229-7yoilsho	5387	13	has	have	VBZ
cord-006229-7yoilsho	5387	14	a	a	DT
cord-006229-7yoilsho	5387	15	potential	potential	NN
cord-006229-7yoilsho	5387	16	to	to	TO
cord-006229-7yoilsho	5387	17	affect	affect	VB
cord-006229-7yoilsho	5387	18	biological	biological	JJ
cord-006229-7yoilsho	5387	19	systems	system	NNS
cord-006229-7yoilsho	5387	20	at	at	IN
cord-006229-7yoilsho	5387	21	low	low	JJ
cord-006229-7yoilsho	5387	22	intensity	intensity	NN
cord-006229-7yoilsho	5387	23	levels	level	NNS
cord-006229-7yoilsho	5387	24	.	.	.
cord-006229-7yoilsho	5388	1	Even	even	RB
cord-006229-7yoilsho	5388	2	though	though	IN
cord-006229-7yoilsho	5388	3	no	no	DT
cord-006229-7yoilsho	5388	4	complete	complete	JJ
cord-006229-7yoilsho	5388	5	consensus	consensus	NN
cord-006229-7yoilsho	5388	6	has	have	VBZ
cord-006229-7yoilsho	5388	7	been	be	VBN
cord-006229-7yoilsho	5388	8	reached	reach	VBN
cord-006229-7yoilsho	5388	9	so	so	RB
cord-006229-7yoilsho	5388	10	far	far	RB
cord-006229-7yoilsho	5388	11	in	in	IN
cord-006229-7yoilsho	5388	12	this	this	DT
cord-006229-7yoilsho	5388	13	issue	issue	NN
cord-006229-7yoilsho	5388	14	,	,	,
cord-006229-7yoilsho	5388	15	most	most	JJS
cord-006229-7yoilsho	5388	16	of	of	IN
cord-006229-7yoilsho	5388	17	the	the	DT
cord-006229-7yoilsho	5388	18	investigations	investigation	NNS
cord-006229-7yoilsho	5388	19	do	do	VBP
cord-006229-7yoilsho	5388	20	not	not	RB
cord-006229-7yoilsho	5388	21	indicate	indicate	VB
cord-006229-7yoilsho	5388	22	a	a	DT
cord-006229-7yoilsho	5388	23	harmful	harmful	JJ
cord-006229-7yoilsho	5388	24	potential	potential	NN
cord-006229-7yoilsho	5388	25	of	of	IN
cord-006229-7yoilsho	5388	26	this	this	DT
cord-006229-7yoilsho	5388	27	radiation	radiation	NN
cord-006229-7yoilsho	5388	28	.	.	.
cord-006229-7yoilsho	5389	1	Two	two	CD
cord-006229-7yoilsho	5389	2	questions	question	NNS
cord-006229-7yoilsho	5389	3	remain	remain	VBP
cord-006229-7yoilsho	5389	4	open	open	JJ
cord-006229-7yoilsho	5389	5	until	until	IN
cord-006229-7yoilsho	5389	6	today	today	NN
cord-006229-7yoilsho	5389	7	,	,	,
cord-006229-7yoilsho	5389	8	i.	i.	NNP
cord-006229-7yoilsho	5389	9	e.	e.	NNP
cord-006229-7yoilsho	5389	10	long	long	JJ
cord-006229-7yoilsho	5389	11	-	-	HYPH
cord-006229-7yoilsho	5389	12	term	term	NN
cord-006229-7yoilsho	5389	13	effects	effect	NNS
cord-006229-7yoilsho	5389	14	and	and	CC
cord-006229-7yoilsho	5389	15	specific	specific	JJ
cord-006229-7yoilsho	5389	16	effects	effect	NNS
cord-006229-7yoilsho	5389	17	on	on	IN
cord-006229-7yoilsho	5389	18	children	child	NNS
cord-006229-7yoilsho	5389	19	.	.	.
cord-006229-7yoilsho	5390	1	It	-PRON-	PRP
cord-006229-7yoilsho	5390	2	has	have	VBZ
cord-006229-7yoilsho	5390	3	been	be	VBN
cord-006229-7yoilsho	5390	4	demonstrated	demonstrate	VBN
cord-006229-7yoilsho	5390	5	that	that	IN
cord-006229-7yoilsho	5390	6	in	in	IN
cord-006229-7yoilsho	5390	7	comparison	comparison	NN
cord-006229-7yoilsho	5390	8	to	to	IN
cord-006229-7yoilsho	5390	9	adults	adult	NNS
cord-006229-7yoilsho	5390	10	,	,	,
cord-006229-7yoilsho	5390	11	children	child	NNS
cord-006229-7yoilsho	5390	12	absorb	absorb	VBP
cord-006229-7yoilsho	5390	13	far	far	RB
cord-006229-7yoilsho	5390	14	higher	high	JJR
cord-006229-7yoilsho	5390	15	doses	dose	NNS
cord-006229-7yoilsho	5390	16	of	of	IN
cord-006229-7yoilsho	5390	17	mobile	mobile	JJ
cord-006229-7yoilsho	5390	18	phone	phone	NN
cord-006229-7yoilsho	5390	19	radiation	radiation	NN
cord-006229-7yoilsho	5390	20	in	in	IN
cord-006229-7yoilsho	5390	21	the	the	DT
cord-006229-7yoilsho	5390	22	skull	skull	NN
cord-006229-7yoilsho	5390	23	,	,	,
cord-006229-7yoilsho	5390	24	particularly	particularly	RB
cord-006229-7yoilsho	5390	25	in	in	IN
cord-006229-7yoilsho	5390	26	the	the	DT
cord-006229-7yoilsho	5390	27	bone	bone	NN
cord-006229-7yoilsho	5390	28	marrow	marrow	NN
cord-006229-7yoilsho	5390	29	,	,	,
cord-006229-7yoilsho	5390	30	where	where	WRB
cord-006229-7yoilsho	5390	31	hematopoiesis	hematopoiesis	NN
cord-006229-7yoilsho	5390	32	takes	take	VBZ
cord-006229-7yoilsho	5390	33	place	place	NN
cord-006229-7yoilsho	5390	34	.	.	.
cord-006229-7yoilsho	5391	1	These	these	DT
cord-006229-7yoilsho	5391	2	absorptions	absorption	NNS
cord-006229-7yoilsho	5391	3	occasionally	occasionally	RB
cord-006229-7yoilsho	5391	4	exceed	exceed	VBP
cord-006229-7yoilsho	5391	5	the	the	DT
cord-006229-7yoilsho	5391	6	recommended	recommend	VBN
cord-006229-7yoilsho	5391	7	safety	safety	NN
cord-006229-7yoilsho	5391	8	limits	limit	NNS
cord-006229-7yoilsho	5391	9	.	.	.
cord-006229-7yoilsho	5392	1	The	the	DT
cord-006229-7yoilsho	5392	2	aim	aim	NN
cord-006229-7yoilsho	5392	3	of	of	IN
cord-006229-7yoilsho	5392	4	this	this	DT
cord-006229-7yoilsho	5392	5	study	study	NN
cord-006229-7yoilsho	5392	6	was	be	VBD
cord-006229-7yoilsho	5392	7	to	to	TO
cord-006229-7yoilsho	5392	8	elucidate	elucidate	VB
cord-006229-7yoilsho	5392	9	,	,	,
cord-006229-7yoilsho	5392	10	whether	whether	IN
cord-006229-7yoilsho	5392	11	cells	cell	NNS
cord-006229-7yoilsho	5392	12	of	of	IN
cord-006229-7yoilsho	5392	13	the	the	DT
cord-006229-7yoilsho	5392	14	hematopoietic	hematopoietic	JJ
cord-006229-7yoilsho	5392	15	system	system	NN
cord-006229-7yoilsho	5392	16	can	can	MD
cord-006229-7yoilsho	5392	17	be	be	VB
cord-006229-7yoilsho	5392	18	affected	affect	VBN
cord-006229-7yoilsho	5392	19	by	by	IN
cord-006229-7yoilsho	5392	20	different	different	JJ
cord-006229-7yoilsho	5392	21	forms	form	NNS
cord-006229-7yoilsho	5392	22	of	of	IN
cord-006229-7yoilsho	5392	23	mobile	mobile	JJ
cord-006229-7yoilsho	5392	24	phone	phone	NN
cord-006229-7yoilsho	5392	25	radiation	radiation	NN
cord-006229-7yoilsho	5392	26	.	.	.
cord-006229-7yoilsho	5393	1	As	as	IN
cord-006229-7yoilsho	5393	2	biological	biological	JJ
cord-006229-7yoilsho	5393	3	systems	system	NNS
cord-006229-7yoilsho	5393	4	,	,	,
cord-006229-7yoilsho	5393	5	two	two	CD
cord-006229-7yoilsho	5393	6	cell	cell	NN
cord-006229-7yoilsho	5393	7	types	type	NNS
cord-006229-7yoilsho	5393	8	were	be	VBD
cord-006229-7yoilsho	5393	9	investigated	investigate	VBN
cord-006229-7yoilsho	5393	10	,	,	,
cord-006229-7yoilsho	5393	11	HL-60	HL-60	NNP
cord-006229-7yoilsho	5393	12	cells	cell	NNS
cord-006229-7yoilsho	5393	13	as	as	IN
cord-006229-7yoilsho	5393	14	an	an	DT
cord-006229-7yoilsho	5393	15	established	establish	VBN
cord-006229-7yoilsho	5393	16	cell	cell	NN
cord-006229-7yoilsho	5393	17	line	line	NN
cord-006229-7yoilsho	5393	18	,	,	,
cord-006229-7yoilsho	5393	19	and	and	CC
cord-006229-7yoilsho	5393	20	human	human	JJ
cord-006229-7yoilsho	5393	21	hematopoietic	hematopoietic	JJ
cord-006229-7yoilsho	5393	22	stem	stem	NN
cord-006229-7yoilsho	5393	23	cells	cell	NNS
cord-006229-7yoilsho	5393	24	.	.	.
cord-006229-7yoilsho	5394	1	The	the	DT
cord-006229-7yoilsho	5394	2	radiation	radiation	NN
cord-006229-7yoilsho	5394	3	was	be	VBD
cord-006229-7yoilsho	5394	4	modulated	modulate	VBN
cord-006229-7yoilsho	5394	5	according	accord	VBG
cord-006229-7yoilsho	5394	6	to	to	IN
cord-006229-7yoilsho	5394	7	the	the	DT
cord-006229-7yoilsho	5394	8	two	two	CD
cord-006229-7yoilsho	5394	9	major	major	JJ
cord-006229-7yoilsho	5394	10	technologies	technology	NNS
cord-006229-7yoilsho	5394	11	,	,	,
cord-006229-7yoilsho	5394	12	GSM	GSM	NNP
cord-006229-7yoilsho	5394	13	(	(	-LRB-
cord-006229-7yoilsho	5394	14	900	900	CD
cord-006229-7yoilsho	5394	15	MHz	MHz	NNPS
cord-006229-7yoilsho	5394	16	)	)	-RRB-
cord-006229-7yoilsho	5394	17	and	and	CC
cord-006229-7yoilsho	5394	18	UMTS	UMTS	NNP
cord-006229-7yoilsho	5394	19	(	(	-LRB-
cord-006229-7yoilsho	5394	20	1950	1950	CD
cord-006229-7yoilsho	5394	21	MHz	MHz	NNPS
cord-006229-7yoilsho	5394	22	)	)	-RRB-
cord-006229-7yoilsho	5394	23	.	.	.
cord-006229-7yoilsho	5395	1	Additionally	additionally	RB
cord-006229-7yoilsho	5395	2	,	,	,
cord-006229-7yoilsho	5395	3	LTE	LTE	NNP
cord-006229-7yoilsho	5395	4	(	(	-LRB-
cord-006229-7yoilsho	5395	5	2.535	2.535	CD
cord-006229-7yoilsho	5395	6	MHz	MHz	NNPS
cord-006229-7yoilsho	5395	7	)	)	-RRB-
cord-006229-7yoilsho	5395	8	modulation	modulation	NN
cord-006229-7yoilsho	5395	9	was	be	VBD
cord-006229-7yoilsho	5395	10	applied	apply	VBN
cord-006229-7yoilsho	5395	11	because	because	IN
cord-006229-7yoilsho	5395	12	this	this	DT
cord-006229-7yoilsho	5395	13	technology	technology	NN
cord-006229-7yoilsho	5395	14	is	be	VBZ
cord-006229-7yoilsho	5395	15	used	use	VBN
cord-006229-7yoilsho	5395	16	worldwide	worldwide	RB
cord-006229-7yoilsho	5395	17	already	already	RB
cord-006229-7yoilsho	5395	18	but	but	CC
cord-006229-7yoilsho	5395	19	has	have	VBZ
cord-006229-7yoilsho	5395	20	not	not	RB
cord-006229-7yoilsho	5395	21	been	be	VBN
cord-006229-7yoilsho	5395	22	studied	study	VBN
cord-006229-7yoilsho	5395	23	sufficiently	sufficiently	RB
cord-006229-7yoilsho	5395	24	.	.	.
cord-006229-7yoilsho	5396	1	Cells	cell	NNS
cord-006229-7yoilsho	5396	2	were	be	VBD
cord-006229-7yoilsho	5396	3	exposed	expose	VBN
cord-006229-7yoilsho	5396	4	for	for	IN
cord-006229-7yoilsho	5396	5	a	a	DT
cord-006229-7yoilsho	5396	6	short	short	JJ
cord-006229-7yoilsho	5396	7	and	and	CC
cord-006229-7yoilsho	5396	8	a	a	DT
cord-006229-7yoilsho	5396	9	long	long	JJ
cord-006229-7yoilsho	5396	10	period	period	NN
cord-006229-7yoilsho	5396	11	and	and	CC
cord-006229-7yoilsho	5396	12	with	with	IN
cord-006229-7yoilsho	5396	13	different	different	JJ
cord-006229-7yoilsho	5396	14	intensities	intensity	NNS
cord-006229-7yoilsho	5396	15	ranging	range	VBG
cord-006229-7yoilsho	5396	16	from	from	IN
cord-006229-7yoilsho	5396	17	0	0	CD
cord-006229-7yoilsho	5396	18	to	to	IN
cord-006229-7yoilsho	5396	19	4	4	CD
cord-006229-7yoilsho	5396	20	W	w	NN
cord-006229-7yoilsho	5396	21	/	/	SYM
cord-006229-7yoilsho	5396	22	kg	kg	NNS
cord-006229-7yoilsho	5396	23	.	.	.
cord-006229-7yoilsho	5397	1	Studied	study	VBN
cord-006229-7yoilsho	5397	2	endpoints	endpoint	NNS
cord-006229-7yoilsho	5397	3	included	include	VBD
cord-006229-7yoilsho	5397	4	oxidative	oxidative	JJ
cord-006229-7yoilsho	5397	5	stress	stress	NN
cord-006229-7yoilsho	5397	6	,	,	,
cord-006229-7yoilsho	5397	7	differentiation	differentiation	NN
cord-006229-7yoilsho	5397	8	,	,	,
cord-006229-7yoilsho	5397	9	DNA	dna	NN
cord-006229-7yoilsho	5397	10	repair	repair	NN
cord-006229-7yoilsho	5397	11	,	,	,
cord-006229-7yoilsho	5397	12	cell	cell	NN
cord-006229-7yoilsho	5397	13	cycle	cycle	NN
cord-006229-7yoilsho	5397	14	,	,	,
cord-006229-7yoilsho	5397	15	DNA	dna	NN
cord-006229-7yoilsho	5397	16	damage	damage	NN
cord-006229-7yoilsho	5397	17	,	,	,
cord-006229-7yoilsho	5397	18	histone	histone	NN
cord-006229-7yoilsho	5397	19	acetylation	acetylation	NN
cord-006229-7yoilsho	5397	20	,	,	,
cord-006229-7yoilsho	5397	21	and	and	CC
cord-006229-7yoilsho	5397	22	apoptosis	apoptosis	NN
cord-006229-7yoilsho	5397	23	.	.	.
cord-006229-7yoilsho	5398	1	Appropriate	appropriate	JJ
cord-006229-7yoilsho	5399	1	negative	negative	JJ
cord-006229-7yoilsho	5399	2	and	and	CC
cord-006229-7yoilsho	5399	3	positive	positive	JJ
cord-006229-7yoilsho	5399	4	controls	control	NNS
cord-006229-7yoilsho	5399	5	were	be	VBD
cord-006229-7yoilsho	5399	6	included	include	VBN
cord-006229-7yoilsho	5399	7	and	and	CC
cord-006229-7yoilsho	5399	8	three	three	CD
cord-006229-7yoilsho	5399	9	independent	independent	JJ
cord-006229-7yoilsho	5399	10	replicate	replicate	VBP
cord-006229-7yoilsho	5399	11	experiments	experiment	NNS
cord-006229-7yoilsho	5399	12	were	be	VBD
cord-006229-7yoilsho	5399	13	performed	perform	VBN
cord-006229-7yoilsho	5399	14	.	.	.
cord-006229-7yoilsho	5400	1	Exposure	exposure	NN
cord-006229-7yoilsho	5400	2	to	to	IN
cord-006229-7yoilsho	5400	3	radiofrequency	radiofrequency	NN
cord-006229-7yoilsho	5400	4	radiation	radiation	NN
cord-006229-7yoilsho	5400	5	did	do	VBD
cord-006229-7yoilsho	5400	6	not	not	RB
cord-006229-7yoilsho	5400	7	induce	induce	VB
cord-006229-7yoilsho	5400	8	any	any	DT
cord-006229-7yoilsho	5400	9	alterations	alteration	NNS
cord-006229-7yoilsho	5400	10	of	of	IN
cord-006229-7yoilsho	5400	11	cell	cell	NN
cord-006229-7yoilsho	5400	12	functions	function	NNS
cord-006229-7yoilsho	5400	13	,	,	,
cord-006229-7yoilsho	5400	14	measured	measure	VBN
cord-006229-7yoilsho	5400	15	as	as	IN
cord-006229-7yoilsho	5400	16	oxidative	oxidative	JJ
cord-006229-7yoilsho	5400	17	stress	stress	NN
cord-006229-7yoilsho	5400	18	and	and	CC
cord-006229-7yoilsho	5400	19	cell	cell	NN
cord-006229-7yoilsho	5400	20	cycle	cycle	NN
cord-006229-7yoilsho	5400	21	.	.	.
cord-006229-7yoilsho	5401	1	Cell	cell	NN
cord-006229-7yoilsho	5401	2	death	death	NN
cord-006229-7yoilsho	5401	3	in	in	IN
cord-006229-7yoilsho	5401	4	the	the	DT
cord-006229-7yoilsho	5401	5	form	form	NN
cord-006229-7yoilsho	5401	6	of	of	IN
cord-006229-7yoilsho	5401	7	apoptosis	apoptosis	NN
cord-006229-7yoilsho	5401	8	was	be	VBD
cord-006229-7yoilsho	5401	9	not	not	RB
cord-006229-7yoilsho	5401	10	observed	observe	VBN
cord-006229-7yoilsho	5401	11	.	.	.
cord-006229-7yoilsho	5402	1	Primary	primary	JJ
cord-006229-7yoilsho	5402	2	DNA	dna	NN
cord-006229-7yoilsho	5402	3	damage	damage	NN
cord-006229-7yoilsho	5402	4	was	be	VBD
cord-006229-7yoilsho	5402	5	not	not	RB
cord-006229-7yoilsho	5402	6	induced	induce	VBN
cord-006229-7yoilsho	5402	7	and	and	CC
cord-006229-7yoilsho	5402	8	DNA	dna	NN
cord-006229-7yoilsho	5402	9	repair	repair	NN
cord-006229-7yoilsho	5402	10	capacity	capacity	NN
cord-006229-7yoilsho	5402	11	for	for	IN
cord-006229-7yoilsho	5402	12	nucleotide	nucleotide	JJ
cord-006229-7yoilsho	5402	13	excision	excision	NN
cord-006229-7yoilsho	5402	14	repair	repair	NN
cord-006229-7yoilsho	5402	15	was	be	VBD
cord-006229-7yoilsho	5402	16	not	not	RB
cord-006229-7yoilsho	5402	17	changed	change	VBN
cord-006229-7yoilsho	5402	18	.	.	.
cord-006229-7yoilsho	5403	1	Epigenetic	epigenetic	JJ
cord-006229-7yoilsho	5403	2	effects	effect	NNS
cord-006229-7yoilsho	5403	3	(	(	-LRB-
cord-006229-7yoilsho	5403	4	measured	measure	VBN
cord-006229-7yoilsho	5403	5	as	as	IN
cord-006229-7yoilsho	5403	6	histone	histone	NN
cord-006229-7yoilsho	5403	7	acetylation	acetylation	NN
cord-006229-7yoilsho	5403	8	)	)	-RRB-
cord-006229-7yoilsho	5403	9	were	be	VBD
cord-006229-7yoilsho	5403	10	not	not	RB
cord-006229-7yoilsho	5403	11	observed	observe	VBN
cord-006229-7yoilsho	5403	12	.	.	.
cord-006229-7yoilsho	5404	1	Finally	finally	RB
cord-006229-7yoilsho	5404	2	,	,	,
cord-006229-7yoilsho	5404	3	differentiation	differentiation	NN
cord-006229-7yoilsho	5404	4	was	be	VBD
cord-006229-7yoilsho	5404	5	not	not	RB
cord-006229-7yoilsho	5404	6	affected	affect	VBN
cord-006229-7yoilsho	5404	7	.	.	.
cord-006229-7yoilsho	5405	1	The	the	DT
cord-006229-7yoilsho	5405	2	effect	effect	NN
cord-006229-7yoilsho	5405	3	of	of	IN
cord-006229-7yoilsho	5405	4	treatment	treatment	NN
cord-006229-7yoilsho	5405	5	with	with	IN
cord-006229-7yoilsho	5405	6	various	various	JJ
cord-006229-7yoilsho	5405	7	chemicals	chemical	NNS
cord-006229-7yoilsho	5405	8	as	as	IN
cord-006229-7yoilsho	5405	9	positive	positive	JJ
cord-006229-7yoilsho	5405	10	controls	control	NNS
cord-006229-7yoilsho	5405	11	was	be	VBD
cord-006229-7yoilsho	5405	12	different	different	JJ
cord-006229-7yoilsho	5405	13	in	in	IN
cord-006229-7yoilsho	5405	14	the	the	DT
cord-006229-7yoilsho	5405	15	two	two	CD
cord-006229-7yoilsho	5405	16	cell	cell	NN
cord-006229-7yoilsho	5405	17	types	type	NNS
cord-006229-7yoilsho	5405	18	.	.	.
cord-006229-7yoilsho	5406	1	All	all	DT
cord-006229-7yoilsho	5406	2	in	in	IN
cord-006229-7yoilsho	5406	3	all	all	DT
cord-006229-7yoilsho	5406	4	,	,	,
cord-006229-7yoilsho	5406	5	mobile	mobile	JJ
cord-006229-7yoilsho	5406	6	phone	phone	NN
cord-006229-7yoilsho	5406	7	radiation	radiation	NN
cord-006229-7yoilsho	5406	8	did	do	VBD
cord-006229-7yoilsho	5406	9	not	not	RB
cord-006229-7yoilsho	5406	10	induce	induce	VB
cord-006229-7yoilsho	5406	11	effects	effect	NNS
cord-006229-7yoilsho	5406	12	on	on	IN
cord-006229-7yoilsho	5406	13	human	human	JJ
cord-006229-7yoilsho	5406	14	hematopoietic	hematopoietic	JJ
cord-006229-7yoilsho	5406	15	cells	cell	NNS
cord-006229-7yoilsho	5406	16	.	.	.
cord-006229-7yoilsho	5407	1	In	in	IN
cord-006229-7yoilsho	5407	2	2014	2014	CD
cord-006229-7yoilsho	5407	3	WHO	who	WP
cord-006229-7yoilsho	5407	4	published	publish	VBD
cord-006229-7yoilsho	5407	5	guidance	guidance	NN
cord-006229-7yoilsho	5407	6	on	on	IN
cord-006229-7yoilsho	5407	7	evaluating	evaluate	VBG
cord-006229-7yoilsho	5407	8	and	and	CC
cord-006229-7yoilsho	5407	9	expressing	express	VBG
cord-006229-7yoilsho	5407	10	uncertainties	uncertainty	NNS
cord-006229-7yoilsho	5407	11	in	in	IN
cord-006229-7yoilsho	5407	12	human	human	JJ
cord-006229-7yoilsho	5407	13	health	health	NN
cord-006229-7yoilsho	5407	14	hazard	hazard	NN
cord-006229-7yoilsho	5407	15	characterisation	characterisation	NN
cord-006229-7yoilsho	5407	16	(	(	-LRB-
cord-006229-7yoilsho	5407	17	HC	HC	NNP
cord-006229-7yoilsho	5407	18	)	)	-RRB-
cord-006229-7yoilsho	5407	19	.	.	.
cord-006229-7yoilsho	5408	1	In	in	IN
cord-006229-7yoilsho	5408	2	this	this	DT
cord-006229-7yoilsho	5408	3	approach	approach	NN
cord-006229-7yoilsho	5408	4	,	,	,
cord-006229-7yoilsho	5408	5	the	the	DT
cord-006229-7yoilsho	5408	6	outcome	outcome	NN
cord-006229-7yoilsho	5408	7	of	of	IN
cord-006229-7yoilsho	5408	8	HC	HC	NNP
cord-006229-7yoilsho	5408	9	is	be	VBZ
cord-006229-7yoilsho	5408	10	expressed	express	VBN
cord-006229-7yoilsho	5408	11	as	as	IN
cord-006229-7yoilsho	5408	12	an	an	DT
cord-006229-7yoilsho	5408	13	interval	interval	NN
cord-006229-7yoilsho	5408	14	or	or	CC
cord-006229-7yoilsho	5408	15	distribution	distribution	NN
cord-006229-7yoilsho	5408	16	rather	rather	RB
cord-006229-7yoilsho	5408	17	than	than	IN
cord-006229-7yoilsho	5408	18	a	a	DT
cord-006229-7yoilsho	5408	19	"	"	``
cord-006229-7yoilsho	5408	20	traditional	traditional	JJ
cord-006229-7yoilsho	5408	21	"	"	''
cord-006229-7yoilsho	5408	22	deterministic	deterministic	JJ
cord-006229-7yoilsho	5408	23	point	point	NN
cord-006229-7yoilsho	5408	24	estimate	estimate	NN
cord-006229-7yoilsho	5408	25	,	,	,
cord-006229-7yoilsho	5408	26	such	such	JJ
cord-006229-7yoilsho	5408	27	as	as	IN
cord-006229-7yoilsho	5408	28	a	a	DT
cord-006229-7yoilsho	5408	29	Reference	reference	NN
cord-006229-7yoilsho	5408	30	Dose	dose	NN
cord-006229-7yoilsho	5408	31	(	(	-LRB-
cord-006229-7yoilsho	5408	32	RfD	rfd	NN
cord-006229-7yoilsho	5408	33	)	)	-RRB-
cord-006229-7yoilsho	5408	34	,	,	,
cord-006229-7yoilsho	5408	35	thereby	thereby	RB
cord-006229-7yoilsho	5408	36	communicating	communicate	VBG
cord-006229-7yoilsho	5408	37	potential	potential	JJ
cord-006229-7yoilsho	5408	38	uncertainties	uncertainty	NNS
cord-006229-7yoilsho	5408	39	more	more	RBR
cord-006229-7yoilsho	5408	40	clearly	clearly	RB
cord-006229-7yoilsho	5408	41	.	.	.
cord-006229-7yoilsho	5409	1	Risk	risk	NN
cord-006229-7yoilsho	5409	2	management	management	NN
cord-006229-7yoilsho	5409	3	protection	protection	NN
cord-006229-7yoilsho	5409	4	goals	goal	NNS
cord-006229-7yoilsho	5409	5	,	,	,
cord-006229-7yoilsho	5409	6	such	such	JJ
cord-006229-7yoilsho	5409	7	as	as	IN
cord-006229-7yoilsho	5409	8	the	the	DT
cord-006229-7yoilsho	5409	9	acceptable	acceptable	JJ
cord-006229-7yoilsho	5409	10	magnitude	magnitude	NN
cord-006229-7yoilsho	5409	11	of	of	IN
cord-006229-7yoilsho	5409	12	effect	effect	NN
cord-006229-7yoilsho	5409	13	(	(	-LRB-
cord-006229-7yoilsho	5409	14	M	M	NNP
cord-006229-7yoilsho	5409	15	)	)	-RRB-
cord-006229-7yoilsho	5409	16	and	and	CC
cord-006229-7yoilsho	5409	17	incidence	incidence	NN
cord-006229-7yoilsho	5409	18	(	(	-LRB-
cord-006229-7yoilsho	5409	19	I	i	NN
cord-006229-7yoilsho	5409	20	)	)	-RRB-
cord-006229-7yoilsho	5409	21	in	in	IN
cord-006229-7yoilsho	5409	22	the	the	DT
cord-006229-7yoilsho	5409	23	population	population	NN
cord-006229-7yoilsho	5409	24	,	,	,
cord-006229-7yoilsho	5409	25	are	be	VBP
cord-006229-7yoilsho	5409	26	made	make	VBN
cord-006229-7yoilsho	5409	27	explicit	explicit	JJ
cord-006229-7yoilsho	5409	28	quantitatively	quantitatively	RB
cord-006229-7yoilsho	5409	29	along	along	IN
cord-006229-7yoilsho	5409	30	with	with	IN
cord-006229-7yoilsho	5409	31	the	the	DT
cord-006229-7yoilsho	5409	32	confidence	confidence	NN
cord-006229-7yoilsho	5409	33	with	with	IN
cord-006229-7yoilsho	5409	34	which	which	WDT
cord-006229-7yoilsho	5409	35	they	-PRON-	PRP
cord-006229-7yoilsho	5409	36	are	be	VBP
cord-006229-7yoilsho	5409	37	achieved	achieve	VBN
cord-006229-7yoilsho	5409	38	,	,	,
cord-006229-7yoilsho	5409	39	e.g.	e.g.	RB
cord-006229-7yoilsho	5409	40	by	by	IN
cord-006229-7yoilsho	5409	41	an	an	DT
cord-006229-7yoilsho	5409	42	RfD.	RfD.	NNP
cord-006229-7yoilsho	5409	43	Specifically	specifically	RB
cord-006229-7yoilsho	5409	44	,	,	,
cord-006229-7yoilsho	5409	45	the	the	DT
cord-006229-7yoilsho	5409	46	goal	goal	NN
cord-006229-7yoilsho	5409	47	of	of	IN
cord-006229-7yoilsho	5409	48	this	this	DT
cord-006229-7yoilsho	5409	49	approach	approach	NN
cord-006229-7yoilsho	5409	50	to	to	IN
cord-006229-7yoilsho	5409	51	HC	HC	NNP
cord-006229-7yoilsho	5409	52	is	be	VBZ
cord-006229-7yoilsho	5409	53	to	to	TO
cord-006229-7yoilsho	5409	54	estimate	estimate	VB
cord-006229-7yoilsho	5409	55	the	the	DT
cord-006229-7yoilsho	5409	56	"	"	``
cord-006229-7yoilsho	5409	57	HD	HD	NNP
cord-006229-7yoilsho	5409	58	M	M	NNP
cord-006229-7yoilsho	5409	59	I	i	NN
cord-006229-7yoilsho	5409	60	"	"	''
cord-006229-7yoilsho	5409	61	,	,	,
cord-006229-7yoilsho	5409	62	i.e.	i.e.	FW
cord-006229-7yoilsho	5409	63	the	the	DT
cord-006229-7yoilsho	5409	64	"	"	``
cord-006229-7yoilsho	5409	65	true	true	JJ
cord-006229-7yoilsho	5409	66	"	"	''
cord-006229-7yoilsho	5409	67	human	human	JJ
cord-006229-7yoilsho	5409	68	dose	dose	NN
cord-006229-7yoilsho	5409	69	associated	associate	VBN
cord-006229-7yoilsho	5409	70	with	with	IN
cord-006229-7yoilsho	5409	71	M	M	NNP
cord-006229-7yoilsho	5409	72	and	and	CC
cord-006229-7yoilsho	5409	73	I	-PRON-	PRP
cord-006229-7yoilsho	5409	74	(	(	-LRB-
cord-006229-7yoilsho	5409	75	e.g.	e.g.	RB
cord-006229-7yoilsho	5409	76	body	body	NN
cord-006229-7yoilsho	5409	77	weight	weight	NN
cord-006229-7yoilsho	5409	78	decreased	decrease	VBD
cord-006229-7yoilsho	5409	79	by	by	IN
cord-006229-7yoilsho	5409	80	≥	≥	CD
cord-006229-7yoilsho	5409	81	10	10	CD
cord-006229-7yoilsho	5409	82	%	%	NN
cord-006229-7yoilsho	5409	83	(	(	-LRB-
cord-006229-7yoilsho	5409	84	M	M	NNP
cord-006229-7yoilsho	5409	85	)	)	-RRB-
cord-006229-7yoilsho	5409	86	in	in	IN
cord-006229-7yoilsho	5409	87	5	5	CD
cord-006229-7yoilsho	5409	88	%	%	NN
cord-006229-7yoilsho	5409	89	(	(	-LRB-
cord-006229-7yoilsho	5409	90	I	i	NN
cord-006229-7yoilsho	5409	91	)	)	-RRB-
cord-006229-7yoilsho	5409	92	of	of	IN
cord-006229-7yoilsho	5409	93	the	the	DT
cord-006229-7yoilsho	5409	94	population	population	NN
cord-006229-7yoilsho	5409	95	)	)	-RRB-
cord-006229-7yoilsho	5409	96	.	.	.
cord-006229-7yoilsho	5410	1	If	if	IN
cord-006229-7yoilsho	5410	2	uncertainties	uncertainty	NNS
cord-006229-7yoilsho	5410	3	are	be	VBP
cord-006229-7yoilsho	5410	4	expressed	express	VBN
cord-006229-7yoilsho	5410	5	by	by	IN
cord-006229-7yoilsho	5410	6	providing	provide	VBG
cord-006229-7yoilsho	5410	7	estimates	estimate	NNS
cord-006229-7yoilsho	5410	8	of	of	IN
cord-006229-7yoilsho	5410	9	the	the	DT
cord-006229-7yoilsho	5410	10	HD	HD	NNP
cord-006229-7yoilsho	5410	11	M	M	NNP
cord-006229-7yoilsho	5410	12	I	I	NNP
cord-006229-7yoilsho	5410	13	as	as	IN
cord-006229-7yoilsho	5410	14	confidence	confidence	NN
cord-006229-7yoilsho	5410	15	intervals	interval	NNS
cord-006229-7yoilsho	5410	16	or	or	CC
cord-006229-7yoilsho	5410	17	uncertainty	uncertainty	NN
cord-006229-7yoilsho	5410	18	distributions	distribution	NNS
cord-006229-7yoilsho	5410	19	,	,	,
cord-006229-7yoilsho	5410	20	both	both	CC
cord-006229-7yoilsho	5410	21	the	the	DT
cord-006229-7yoilsho	5410	22	"	"	``
cord-006229-7yoilsho	5410	23	degree	degree	NN
cord-006229-7yoilsho	5410	24	of	of	IN
cord-006229-7yoilsho	5410	25	uncertainty	uncertainty	NN
cord-006229-7yoilsho	5410	26	"	"	''
cord-006229-7yoilsho	5410	27	(	(	-LRB-
cord-006229-7yoilsho	5410	28	ratio	ratio	NN
cord-006229-7yoilsho	5410	29	of	of	IN
cord-006229-7yoilsho	5410	30	upper	upper	JJ
cord-006229-7yoilsho	5410	31	and	and	CC
cord-006229-7yoilsho	5410	32	lower	low	JJR
cord-006229-7yoilsho	5410	33	limit	limit	NN
cord-006229-7yoilsho	5410	34	of	of	IN
cord-006229-7yoilsho	5410	35	the	the	DT
cord-006229-7yoilsho	5410	36	interval	interval	NN
cord-006229-7yoilsho	5410	37	/	/	SYM
cord-006229-7yoilsho	5410	38	relevant	relevant	JJ
cord-006229-7yoilsho	5410	39	distribution	distribution	NN
cord-006229-7yoilsho	5410	40	segment	segment	NN
cord-006229-7yoilsho	5410	41	)	)	-RRB-
cord-006229-7yoilsho	5410	42	and	and	CC
cord-006229-7yoilsho	5410	43	the	the	DT
cord-006229-7yoilsho	5410	44	"	"	``
cord-006229-7yoilsho	5410	45	coverage	coverage	NN
cord-006229-7yoilsho	5410	46	"	"	''
cord-006229-7yoilsho	5410	47	(	(	-LRB-
cord-006229-7yoilsho	5410	48	statistical	statistical	JJ
cord-006229-7yoilsho	5410	49	confidence	confidence	NN
cord-006229-7yoilsho	5410	50	)	)	-RRB-
cord-006229-7yoilsho	5410	51	associated	associate	VBN
cord-006229-7yoilsho	5410	52	with	with	IN
cord-006229-7yoilsho	5410	53	a	a	DT
cord-006229-7yoilsho	5410	54	given	give	VBN
cord-006229-7yoilsho	5410	55	RfD	rfd	NN
cord-006229-7yoilsho	5410	56	value	value	NN
cord-006229-7yoilsho	5410	57	can	can	MD
cord-006229-7yoilsho	5410	58	be	be	VB
cord-006229-7yoilsho	5410	59	characterised	characterise	VBN
cord-006229-7yoilsho	5410	60	.	.	.
cord-006229-7yoilsho	5411	1	Alternatively	alternatively	RB
cord-006229-7yoilsho	5411	2	,	,	,
cord-006229-7yoilsho	5411	3	one	one	PRP
cord-006229-7yoilsho	5411	4	may	may	MD
cord-006229-7yoilsho	5411	5	start	start	VB
cord-006229-7yoilsho	5411	6	from	from	IN
cord-006229-7yoilsho	5411	7	a	a	DT
cord-006229-7yoilsho	5411	8	chosen	choose	VBN
cord-006229-7yoilsho	5411	9	coverage	coverage	NN
cord-006229-7yoilsho	5411	10	and	and	CC
cord-006229-7yoilsho	5411	11	calculate	calculate	VB
cord-006229-7yoilsho	5411	12	the	the	DT
cord-006229-7yoilsho	5411	13	associated	associated	JJ
cord-006229-7yoilsho	5411	14	"	"	``
cord-006229-7yoilsho	5411	15	probabilistic	probabilistic	JJ
cord-006229-7yoilsho	5411	16	RfD	rfd	NN
cord-006229-7yoilsho	5411	17	"	"	''
cord-006229-7yoilsho	5411	18	.	.	.
cord-006229-7yoilsho	5412	1	Uncertainty	uncertainty	NN
cord-006229-7yoilsho	5412	2	in	in	IN
cord-006229-7yoilsho	5412	3	each	each	DT
cord-006229-7yoilsho	5412	4	HC	HC	NNP
cord-006229-7yoilsho	5412	5	aspect	aspect	NN
cord-006229-7yoilsho	5412	6	,	,	,
cord-006229-7yoilsho	5412	7	e.g.	e.g.	RB
cord-006229-7yoilsho	5412	8	inter-/intraspecies	inter-/intraspecies	CD
cord-006229-7yoilsho	5412	9	or	or	CC
cord-006229-7yoilsho	5412	10	time	time	NN
cord-006229-7yoilsho	5412	11	extrapolation	extrapolation	NN
cord-006229-7yoilsho	5412	12	,	,	,
cord-006229-7yoilsho	5412	13	can	can	MD
cord-006229-7yoilsho	5412	14	be	be	VB
cord-006229-7yoilsho	5412	15	characterised	characterise	VBN
cord-006229-7yoilsho	5412	16	by	by	IN
cord-006229-7yoilsho	5412	17	a	a	DT
cord-006229-7yoilsho	5412	18	"	"	``
cord-006229-7yoilsho	5412	19	Generic	generic	JJ
cord-006229-7yoilsho	5412	20	Default	default	NN
cord-006229-7yoilsho	5412	21	Uncertainty	uncertainty	NN
cord-006229-7yoilsho	5412	22	Distribution	distribution	NN
cord-006229-7yoilsho	5412	23	"	"	''
cord-006229-7yoilsho	5412	24	which	which	WDT
cord-006229-7yoilsho	5412	25	has	have	VBZ
cord-006229-7yoilsho	5412	26	been	be	VBN
cord-006229-7yoilsho	5412	27	derived	derive	VBN
cord-006229-7yoilsho	5412	28	from	from	IN
cord-006229-7yoilsho	5412	29	historical	historical	JJ
cord-006229-7yoilsho	5412	30	data	datum	NNS
cord-006229-7yoilsho	5412	31	,	,	,
cord-006229-7yoilsho	5412	32	but	but	CC
cord-006229-7yoilsho	5412	33	may	may	MD
cord-006229-7yoilsho	5412	34	be	be	VB
cord-006229-7yoilsho	5412	35	replaced	replace	VBN
cord-006229-7yoilsho	5412	36	by	by	IN
cord-006229-7yoilsho	5412	37	a	a	DT
cord-006229-7yoilsho	5412	38	substance	substance	NN
cord-006229-7yoilsho	5412	39	-	-	HYPH
cord-006229-7yoilsho	5412	40	or	or	CC
cord-006229-7yoilsho	5412	41	effect	effect	NN
cord-006229-7yoilsho	5412	42	-	-	HYPH
cord-006229-7yoilsho	5412	43	specific	specific	JJ
cord-006229-7yoilsho	5412	44	distribution	distribution	NN
cord-006229-7yoilsho	5412	45	(	(	-LRB-
cord-006229-7yoilsho	5412	46	analogous	analogous	JJ
cord-006229-7yoilsho	5412	47	to	to	IN
cord-006229-7yoilsho	5412	48	a	a	DT
cord-006229-7yoilsho	5412	49	chemical	chemical	NN
cord-006229-7yoilsho	5412	50	-	-	HYPH
cord-006229-7yoilsho	5412	51	specific	specific	JJ
cord-006229-7yoilsho	5412	52	adjustment	adjustment	NN
cord-006229-7yoilsho	5412	53	factor	factor	NN
cord-006229-7yoilsho	5412	54	in	in	IN
cord-006229-7yoilsho	5412	55	the	the	DT
cord-006229-7yoilsho	5412	56	"	"	``
cord-006229-7yoilsho	5412	57	traditional	traditional	JJ
cord-006229-7yoilsho	5412	58	"	"	''
cord-006229-7yoilsho	5412	59	deterministic	deterministic	JJ
cord-006229-7yoilsho	5412	60	approach	approach	NN
cord-006229-7yoilsho	5412	61	)	)	-RRB-
cord-006229-7yoilsho	5412	62	,	,	,
cord-006229-7yoilsho	5412	63	where	where	WRB
cord-006229-7yoilsho	5412	64	available	available	JJ
cord-006229-7yoilsho	5412	65	.	.	.
cord-006229-7yoilsho	5413	1	The	the	DT
cord-006229-7yoilsho	5413	2	uncertainty	uncertainty	NN
cord-006229-7yoilsho	5413	3	distributions	distribution	NNS
cord-006229-7yoilsho	5413	4	for	for	IN
cord-006229-7yoilsho	5413	5	the	the	DT
cord-006229-7yoilsho	5413	6	individual	individual	JJ
cord-006229-7yoilsho	5413	7	HC	HC	NNP
cord-006229-7yoilsho	5413	8	aspects	aspect	NNS
cord-006229-7yoilsho	5413	9	can	can	MD
cord-006229-7yoilsho	5413	10	then	then	RB
cord-006229-7yoilsho	5413	11	be	be	VB
cord-006229-7yoilsho	5413	12	combined	combine	VBN
cord-006229-7yoilsho	5413	13	into	into	IN
cord-006229-7yoilsho	5413	14	an	an	DT
cord-006229-7yoilsho	5413	15	overall	overall	JJ
cord-006229-7yoilsho	5413	16	uncertainty	uncertainty	NN
cord-006229-7yoilsho	5413	17	interval	interval	NN
cord-006229-7yoilsho	5413	18	/	/	SYM
cord-006229-7yoilsho	5413	19	distribution	distribution	NN
cord-006229-7yoilsho	5413	20	in	in	IN
cord-006229-7yoilsho	5413	21	(	(	-LRB-
cord-006229-7yoilsho	5413	22	1	1	CD
cord-006229-7yoilsho	5413	23	)	)	-RRB-
cord-006229-7yoilsho	5413	24	a	a	DT
cord-006229-7yoilsho	5413	25	simple	simple	JJ
cord-006229-7yoilsho	5413	26	non	non	JJ
cord-006229-7yoilsho	5413	27	-	-	JJ
cord-006229-7yoilsho	5413	28	probabilistic	probabilistic	JJ
cord-006229-7yoilsho	5413	29	way	way	NN
cord-006229-7yoilsho	5413	30	,	,	,
cord-006229-7yoilsho	5413	31	(	(	-LRB-
cord-006229-7yoilsho	5413	32	2	2	LS
cord-006229-7yoilsho	5413	33	)	)	-RRB-
cord-006229-7yoilsho	5413	34	a	a	DT
cord-006229-7yoilsho	5413	35	more	more	RBR
cord-006229-7yoilsho	5413	36	refined	refined	JJ
cord-006229-7yoilsho	5413	37	"	"	''
cord-006229-7yoilsho	5413	38	Approximate	Approximate	NNP
cord-006229-7yoilsho	5413	39	Probabilistic	Probabilistic	NNP
cord-006229-7yoilsho	5413	40	Analysis	Analysis	NNP
cord-006229-7yoilsho	5413	41	"	"	''
cord-006229-7yoilsho	5413	42	(	(	-LRB-
cord-006229-7yoilsho	5413	43	APROBA	APROBA	NNP
cord-006229-7yoilsho	5413	44	,	,	,
cord-006229-7yoilsho	5413	45	a	a	DT
cord-006229-7yoilsho	5413	46	free	free	JJ
cord-006229-7yoilsho	5413	47	spreadsheet	spreadsheet	NN
cord-006229-7yoilsho	5413	48	tool	tool	NN
cord-006229-7yoilsho	5413	49	for	for	IN
cord-006229-7yoilsho	5413	50	easy	easy	JJ
cord-006229-7yoilsho	5413	51	implementation	implementation	NN
cord-006229-7yoilsho	5413	52	also	also	RB
cord-006229-7yoilsho	5413	53	by	by	IN
cord-006229-7yoilsho	5413	54	non	non	NNS
cord-006229-7yoilsho	5413	55	-	-	NNS
cord-006229-7yoilsho	5413	56	statisticians	statistician	NNS
cord-006229-7yoilsho	5413	57	is	be	VBZ
cord-006229-7yoilsho	5413	58	available	available	JJ
cord-006229-7yoilsho	5413	59	from	from	IN
cord-006229-7yoilsho	5413	60	the	the	DT
cord-006229-7yoilsho	5413	61	WHO	WHO	NNP
cord-006229-7yoilsho	5413	62	website	website	NN
cord-006229-7yoilsho	5413	63	)	)	-RRB-
cord-006229-7yoilsho	5413	64	,	,	,
cord-006229-7yoilsho	5413	65	or	or	CC
cord-006229-7yoilsho	5413	66	(	(	-LRB-
cord-006229-7yoilsho	5413	67	3	3	LS
cord-006229-7yoilsho	5413	68	)	)	-RRB-
cord-006229-7yoilsho	5413	69	a	a	DT
cord-006229-7yoilsho	5413	70	fully	fully	RB
cord-006229-7yoilsho	5413	71	probabilistic	probabilistic	JJ
cord-006229-7yoilsho	5413	72	Monte	Monte	NNP
cord-006229-7yoilsho	5413	73	Carlo	Carlo	NNP
cord-006229-7yoilsho	5413	74	analysis	analysis	NN
cord-006229-7yoilsho	5413	75	.	.	.
cord-006229-7yoilsho	5414	1	The	the	DT
cord-006229-7yoilsho	5414	2	HC	HC	NNP
cord-006229-7yoilsho	5414	3	aspects	aspect	NNS
cord-006229-7yoilsho	5414	4	contributing	contribute	VBG
cord-006229-7yoilsho	5414	5	most	most	RBS
cord-006229-7yoilsho	5414	6	to	to	IN
cord-006229-7yoilsho	5414	7	overall	overall	JJ
cord-006229-7yoilsho	5414	8	uncertainty	uncertainty	NN
cord-006229-7yoilsho	5414	9	are	be	VBP
cord-006229-7yoilsho	5414	10	also	also	RB
cord-006229-7yoilsho	5414	11	identified	identify	VBN
cord-006229-7yoilsho	5414	12	and	and	CC
cord-006229-7yoilsho	5414	13	may	may	MD
cord-006229-7yoilsho	5414	14	be	be	VB
cord-006229-7yoilsho	5414	15	prioritised	prioritise	VBN
cord-006229-7yoilsho	5414	16	for	for	IN
cord-006229-7yoilsho	5414	17	refinement	refinement	NN
cord-006229-7yoilsho	5414	18	in	in	IN
cord-006229-7yoilsho	5414	19	a	a	DT
cord-006229-7yoilsho	5414	20	next	next	JJ
cord-006229-7yoilsho	5414	21	assessment	assessment	NN
cord-006229-7yoilsho	5414	22	tier	tier	NN
cord-006229-7yoilsho	5414	23	.	.	.
cord-006229-7yoilsho	5415	1	The	the	DT
cord-006229-7yoilsho	5415	2	WHO	who	WP
cord-006229-7yoilsho	5415	3	approach	approach	NN
cord-006229-7yoilsho	5415	4	uses	use	VBZ
cord-006229-7yoilsho	5415	5	a	a	DT
cord-006229-7yoilsho	5415	6	tiered	tiered	JJ
cord-006229-7yoilsho	5415	7	strategy	strategy	NN
cord-006229-7yoilsho	5415	8	which	which	WDT
cord-006229-7yoilsho	5415	9	may	may	MD
cord-006229-7yoilsho	5415	10	start	start	VB
cord-006229-7yoilsho	5415	11	with	with	IN
cord-006229-7yoilsho	5415	12	evaluating	evaluate	VBG
cord-006229-7yoilsho	5415	13	the	the	DT
cord-006229-7yoilsho	5415	14	uncertainties	uncertainty	NNS
cord-006229-7yoilsho	5415	15	in	in	IN
cord-006229-7yoilsho	5415	16	the	the	DT
cord-006229-7yoilsho	5415	17	outcome	outcome	NN
cord-006229-7yoilsho	5415	18	of	of	IN
cord-006229-7yoilsho	5415	19	a	a	DT
cord-006229-7yoilsho	5415	20	"	"	``
cord-006229-7yoilsho	5415	21	traditional	traditional	JJ
cord-006229-7yoilsho	5415	22	"	"	''
cord-006229-7yoilsho	5415	23	deterministic	deterministic	JJ
cord-006229-7yoilsho	5415	24	HC	hc	NN
cord-006229-7yoilsho	5415	25	.	.	.
cord-006229-7yoilsho	5416	1	In	in	IN
cord-006229-7yoilsho	5416	2	this	this	DT
cord-006229-7yoilsho	5416	3	way	way	NN
cord-006229-7yoilsho	5416	4	it	-PRON-	PRP
cord-006229-7yoilsho	5416	5	represents	represent	VBZ
cord-006229-7yoilsho	5416	6	a	a	DT
cord-006229-7yoilsho	5416	7	unified	unified	JJ
cord-006229-7yoilsho	5416	8	framework	framework	NN
cord-006229-7yoilsho	5416	9	integrating	integrate	VBG
cord-006229-7yoilsho	5416	10	deterministic	deterministic	JJ
cord-006229-7yoilsho	5416	11	and	and	CC
cord-006229-7yoilsho	5416	12	probabilistic	probabilistic	JJ
cord-006229-7yoilsho	5416	13	HC	HC	NNP
cord-006229-7yoilsho	5416	14	methodologies	methodology	NNS
cord-006229-7yoilsho	5416	15	.	.	.
cord-006229-7yoilsho	5417	1	Moreover	moreover	RB
cord-006229-7yoilsho	5417	2	,	,	,
cord-006229-7yoilsho	5417	3	the	the	DT
cord-006229-7yoilsho	5417	4	concept	concept	NN
cord-006229-7yoilsho	5417	5	can	can	MD
cord-006229-7yoilsho	5417	6	be	be	VB
cord-006229-7yoilsho	5417	7	easily	easily	RB
cord-006229-7yoilsho	5417	8	combined	combine	VBN
cord-006229-7yoilsho	5417	9	with	with	IN
cord-006229-7yoilsho	5417	10	exposure	exposure	NN
cord-006229-7yoilsho	5417	11	uncertainty	uncertainty	NN
cord-006229-7yoilsho	5417	12	assessment	assessment	NN
cord-006229-7yoilsho	5417	13	.	.	.
cord-006229-7yoilsho	5418	1	Risk	risk	NN
cord-006229-7yoilsho	5418	2	managers	manager	NNS
cord-006229-7yoilsho	5418	3	may	may	MD
cord-006229-7yoilsho	5418	4	use	use	VB
cord-006229-7yoilsho	5418	5	the	the	DT
cord-006229-7yoilsho	5418	6	additional	additional	JJ
cord-006229-7yoilsho	5418	7	information	information	NN
cord-006229-7yoilsho	5418	8	in	in	IN
cord-006229-7yoilsho	5418	9	better	well	JJR
cord-006229-7yoilsho	5418	10	weighing	weigh	VBG
cord-006229-7yoilsho	5418	11	potential	potential	JJ
cord-006229-7yoilsho	5418	12	health	health	NN
cord-006229-7yoilsho	5418	13	effects	effect	NNS
cord-006229-7yoilsho	5418	14	against	against	IN
cord-006229-7yoilsho	5418	15	other	other	JJ
cord-006229-7yoilsho	5418	16	interests	interest	NNS
cord-006229-7yoilsho	5418	17	.	.	.
cord-006229-7yoilsho	5419	1	When	when	WRB
cord-006229-7yoilsho	5419	2	they	-PRON-	PRP
cord-006229-7yoilsho	5419	3	consider	consider	VBP
cord-006229-7yoilsho	5419	4	the	the	DT
cord-006229-7yoilsho	5419	5	overall	overall	JJ
cord-006229-7yoilsho	5419	6	uncertainty	uncertainty	NN
cord-006229-7yoilsho	5419	7	larger	large	JJR
cord-006229-7yoilsho	5419	8	than	than	IN
cord-006229-7yoilsho	5419	9	desirable	desirable	JJ
cord-006229-7yoilsho	5419	10	in	in	IN
cord-006229-7yoilsho	5419	11	view	view	NN
cord-006229-7yoilsho	5419	12	of	of	IN
cord-006229-7yoilsho	5419	13	the	the	DT
cord-006229-7yoilsho	5419	14	problem	problem	NN
cord-006229-7yoilsho	5419	15	formulation	formulation	NN
cord-006229-7yoilsho	5419	16	,	,	,
cord-006229-7yoilsho	5419	17	they	-PRON-	PRP
cord-006229-7yoilsho	5419	18	may	may	MD
cord-006229-7yoilsho	5419	19	decide	decide	VB
cord-006229-7yoilsho	5419	20	to	to	TO
cord-006229-7yoilsho	5419	21	ask	ask	VB
cord-006229-7yoilsho	5419	22	for	for	IN
cord-006229-7yoilsho	5419	23	a	a	DT
cord-006229-7yoilsho	5419	24	more	more	RBR
cord-006229-7yoilsho	5419	25	refined	refined	JJ
cord-006229-7yoilsho	5419	26	(	(	-LRB-
cord-006229-7yoilsho	5419	27	higher	high	JJR
cord-006229-7yoilsho	5419	28	tier	tier	NN
cord-006229-7yoilsho	5419	29	)	)	-RRB-
cord-006229-7yoilsho	5419	30	assessment	assessment	NN
cord-006229-7yoilsho	5419	31	.	.	.
cord-006229-7yoilsho	5420	1	If	if	IN
cord-006229-7yoilsho	5420	2	all	all	DT
cord-006229-7yoilsho	5420	3	possibilities	possibility	NNS
cord-006229-7yoilsho	5420	4	for	for	IN
cord-006229-7yoilsho	5420	5	refinement	refinement	NN
cord-006229-7yoilsho	5420	6	are	be	VBP
cord-006229-7yoilsho	5420	7	exhausted	exhaust	VBN
cord-006229-7yoilsho	5420	8	,	,	,
cord-006229-7yoilsho	5420	9	the	the	DT
cord-006229-7yoilsho	5420	10	new	new	JJ
cord-006229-7yoilsho	5420	11	approach	approach	NN
cord-006229-7yoilsho	5420	12	can	can	MD
cord-006229-7yoilsho	5420	13	also	also	RB
cord-006229-7yoilsho	5420	14	aid	aid	VB
cord-006229-7yoilsho	5420	15	in	in	IN
cord-006229-7yoilsho	5420	16	the	the	DT
cord-006229-7yoilsho	5420	17	selection	selection	NN
cord-006229-7yoilsho	5420	18	of	of	IN
cord-006229-7yoilsho	5420	19	new	new	JJ
cord-006229-7yoilsho	5420	20	data	datum	NNS
cord-006229-7yoilsho	5420	21	which	which	WDT
cord-006229-7yoilsho	5420	22	might	may	MD
cord-006229-7yoilsho	5420	23	need	need	VB
cord-006229-7yoilsho	5420	24	to	to	TO
cord-006229-7yoilsho	5420	25	be	be	VB
cord-006229-7yoilsho	5420	26	generated	generate	VBN
cord-006229-7yoilsho	5420	27	.	.	.
cord-006229-7yoilsho	5421	1	Due	due	IN
cord-006229-7yoilsho	5421	2	to	to	IN
cord-006229-7yoilsho	5421	3	a	a	DT
cord-006229-7yoilsho	5421	4	constant	constant	JJ
cord-006229-7yoilsho	5421	5	improvement	improvement	NN
cord-006229-7yoilsho	5421	6	in	in	IN
cord-006229-7yoilsho	5421	7	analytical	analytical	JJ
cord-006229-7yoilsho	5421	8	methods	method	NNS
cord-006229-7yoilsho	5421	9	an	an	DT
cord-006229-7yoilsho	5421	10	increasing	increase	VBG
cord-006229-7yoilsho	5421	11	number	number	NN
cord-006229-7yoilsho	5421	12	of	of	IN
cord-006229-7yoilsho	5421	13	substances	substance	NNS
cord-006229-7yoilsho	5421	14	are	be	VBP
cord-006229-7yoilsho	5421	15	found	find	VBN
cord-006229-7yoilsho	5421	16	in	in	IN
cord-006229-7yoilsho	5421	17	drinking	drinking	NN
cord-006229-7yoilsho	5421	18	water	water	NN
cord-006229-7yoilsho	5421	19	.	.	.
cord-006229-7yoilsho	5422	1	The	the	DT
cord-006229-7yoilsho	5422	2	joint	joint	JJ
cord-006229-7yoilsho	5422	3	project	project	NN
cord-006229-7yoilsho	5422	4	ToxBox	ToxBox	NNP
cord-006229-7yoilsho	5422	5	aimed	aim	VBD
cord-006229-7yoilsho	5422	6	for	for	IN
cord-006229-7yoilsho	5422	7	the	the	DT
cord-006229-7yoilsho	5422	8	development	development	NN
cord-006229-7yoilsho	5422	9	of	of	IN
cord-006229-7yoilsho	5422	10	a	a	DT
cord-006229-7yoilsho	5422	11	reliable	reliable	JJ
cord-006229-7yoilsho	5422	12	test	test	NN
cord-006229-7yoilsho	5422	13	battery	battery	NN
cord-006229-7yoilsho	5422	14	,	,	,
cord-006229-7yoilsho	5422	15	allowing	allow	VBG
cord-006229-7yoilsho	5422	16	for	for	IN
cord-006229-7yoilsho	5422	17	a	a	DT
cord-006229-7yoilsho	5422	18	rapid	rapid	JJ
cord-006229-7yoilsho	5422	19	evaluation	evaluation	NN
cord-006229-7yoilsho	5422	20	of	of	IN
cord-006229-7yoilsho	5422	21	single	single	JJ
cord-006229-7yoilsho	5422	22	substances	substance	NNS
cord-006229-7yoilsho	5422	23	in	in	IN
cord-006229-7yoilsho	5422	24	water	water	NN
cord-006229-7yoilsho	5422	25	.	.	.
cord-006229-7yoilsho	5423	1	Eleven	eleven	CD
cord-006229-7yoilsho	5423	2	partners	partner	NNS
cord-006229-7yoilsho	5423	3	either	either	CC
cord-006229-7yoilsho	5423	4	from	from	IN
cord-006229-7yoilsho	5423	5	the	the	DT
cord-006229-7yoilsho	5423	6	research	research	NN
cord-006229-7yoilsho	5423	7	(	(	-LRB-
cord-006229-7yoilsho	5423	8	nine	nine	CD
cord-006229-7yoilsho	5423	9	)	)	-RRB-
cord-006229-7yoilsho	5423	10	or	or	CC
cord-006229-7yoilsho	5423	11	the	the	DT
cord-006229-7yoilsho	5423	12	business	business	NN
cord-006229-7yoilsho	5423	13	sector	sector	NN
cord-006229-7yoilsho	5423	14	(	(	-LRB-
cord-006229-7yoilsho	5423	15	2	2	CD
cord-006229-7yoilsho	5423	16	)	)	-RRB-
cord-006229-7yoilsho	5423	17	formed	form	VBD
cord-006229-7yoilsho	5423	18	the	the	DT
cord-006229-7yoilsho	5423	19	project	project	NN
cord-006229-7yoilsho	5423	20	.	.	.
cord-006229-7yoilsho	5424	1	The	the	DT
cord-006229-7yoilsho	5424	2	attention	attention	NN
cord-006229-7yoilsho	5424	3	was	be	VBD
cord-006229-7yoilsho	5424	4	focused	focus	VBN
cord-006229-7yoilsho	5424	5	on	on	IN
cord-006229-7yoilsho	5424	6	genotoxic	genotoxic	JJ
cord-006229-7yoilsho	5424	7	,	,	,
cord-006229-7yoilsho	5424	8	neurotoxic	neurotoxic	JJ
cord-006229-7yoilsho	5424	9	and	and	CC
cord-006229-7yoilsho	5424	10	endocrine	endocrine	JJ
cord-006229-7yoilsho	5424	11	effects	effect	NNS
cord-006229-7yoilsho	5424	12	,	,	,
cord-006229-7yoilsho	5424	13	which	which	WDT
cord-006229-7yoilsho	5424	14	are	be	VBP
cord-006229-7yoilsho	5424	15	considered	consider	VBN
cord-006229-7yoilsho	5424	16	to	to	TO
cord-006229-7yoilsho	5424	17	be	be	VB
cord-006229-7yoilsho	5424	18	of	of	IN
cord-006229-7yoilsho	5424	19	most	most	JJS
cord-006229-7yoilsho	5424	20	concern	concern	NN
cord-006229-7yoilsho	5424	21	to	to	IN
cord-006229-7yoilsho	5424	22	the	the	DT
cord-006229-7yoilsho	5424	23	consumer	consumer	NN
cord-006229-7yoilsho	5424	24	.	.	.
cord-006229-7yoilsho	5425	1	By	by	IN
cord-006229-7yoilsho	5425	2	the	the	DT
cord-006229-7yoilsho	5425	3	end	end	NN
cord-006229-7yoilsho	5425	4	of	of	IN
cord-006229-7yoilsho	5425	5	the	the	DT
cord-006229-7yoilsho	5425	6	project	project	NN
cord-006229-7yoilsho	5425	7	a	a	DT
cord-006229-7yoilsho	5425	8	set	set	NN
cord-006229-7yoilsho	5425	9	of	of	IN
cord-006229-7yoilsho	5425	10	guidelines	guideline	NNS
cord-006229-7yoilsho	5425	11	is	be	VBZ
cord-006229-7yoilsho	5425	12	published	publish	VBN
cord-006229-7yoilsho	5425	13	that	that	WDT
cord-006229-7yoilsho	5425	14	describes	describe	VBZ
cord-006229-7yoilsho	5425	15	the	the	DT
cord-006229-7yoilsho	5425	16	analytical	analytical	JJ
cord-006229-7yoilsho	5425	17	methods	method	NNS
cord-006229-7yoilsho	5425	18	in	in	IN
cord-006229-7yoilsho	5425	19	detail	detail	NN
cord-006229-7yoilsho	5425	20	.	.	.
cord-006229-7yoilsho	5426	1	The	the	DT
cord-006229-7yoilsho	5426	2	project	project	NN
cord-006229-7yoilsho	5426	3	was	be	VBD
cord-006229-7yoilsho	5426	4	based	base	VBN
cord-006229-7yoilsho	5426	5	on	on	IN
cord-006229-7yoilsho	5426	6	a	a	DT
cord-006229-7yoilsho	5426	7	theoretical	theoretical	JJ
cord-006229-7yoilsho	5426	8	concept	concept	NN
cord-006229-7yoilsho	5426	9	,	,	,
cord-006229-7yoilsho	5426	10	called	call	VBN
cord-006229-7yoilsho	5426	11	"	"	``
cord-006229-7yoilsho	5426	12	Health	Health	NNP
cord-006229-7yoilsho	5426	13	-	-	HYPH
cord-006229-7yoilsho	5426	14	related	relate	VBN
cord-006229-7yoilsho	5426	15	indicator	indicator	NN
cord-006229-7yoilsho	5426	16	value	value	NN
cord-006229-7yoilsho	5426	17	"	"	''
cord-006229-7yoilsho	5426	18	(	(	-LRB-
cord-006229-7yoilsho	5426	19	HRIV	HRIV	NNP
cord-006229-7yoilsho	5426	20	)	)	-RRB-
cord-006229-7yoilsho	5426	21	,	,	,
cord-006229-7yoilsho	5426	22	which	which	WDT
cord-006229-7yoilsho	5426	23	was	be	VBD
cord-006229-7yoilsho	5426	24	developed	develop	VBN
cord-006229-7yoilsho	5426	25	by	by	IN
cord-006229-7yoilsho	5426	26	the	the	DT
cord-006229-7yoilsho	5426	27	German	German	NNP
cord-006229-7yoilsho	5426	28	Federal	Federal	NNP
cord-006229-7yoilsho	5426	29	Environment	Environment	NNP
cord-006229-7yoilsho	5426	30	Agency	Agency	NNP
cord-006229-7yoilsho	5426	31	(	(	-LRB-
cord-006229-7yoilsho	5426	32	UBA	UBA	NNP
cord-006229-7yoilsho	5426	33	)	)	-RRB-
cord-006229-7yoilsho	5426	34	for	for	IN
cord-006229-7yoilsho	5426	35	the	the	DT
cord-006229-7yoilsho	5426	36	assessment	assessment	NN
cord-006229-7yoilsho	5426	37	of	of	IN
cord-006229-7yoilsho	5426	38	substances	substance	NNS
cord-006229-7yoilsho	5426	39	with	with	IN
cord-006229-7yoilsho	5426	40	incomplete	incomplete	JJ
cord-006229-7yoilsho	5426	41	toxicological	toxicological	JJ
cord-006229-7yoilsho	5426	42	data	datum	NNS
cord-006229-7yoilsho	5426	43	.	.	.
cord-006229-7yoilsho	5427	1	Depending	depend	VBG
cord-006229-7yoilsho	5427	2	on	on	IN
cord-006229-7yoilsho	5427	3	the	the	DT
cord-006229-7yoilsho	5427	4	type	type	NN
cord-006229-7yoilsho	5427	5	of	of	IN
cord-006229-7yoilsho	5427	6	effect	effect	NN
cord-006229-7yoilsho	5427	7	a	a	DT
cord-006229-7yoilsho	5427	8	HRIV	HRIV	NNP
cord-006229-7yoilsho	5427	9	between	between	IN
cord-006229-7yoilsho	5427	10	0.1	0.1	CD
cord-006229-7yoilsho	5427	11	and	and	CC
cord-006229-7yoilsho	5427	12	3.0	3.0	CD
cord-006229-7yoilsho	5427	13	µg	µg	NN
cord-006229-7yoilsho	5427	14	/	/	SYM
cord-006229-7yoilsho	5427	15	laws	law	NNS
cord-006229-7yoilsho	5427	16	derived	derive	VBN
cord-006229-7yoilsho	5427	17	for	for	IN
cord-006229-7yoilsho	5427	18	the	the	DT
cord-006229-7yoilsho	5427	19	substance	substance	NN
cord-006229-7yoilsho	5427	20	which	which	WDT
cord-006229-7yoilsho	5427	21	had	have	VBD
cord-006229-7yoilsho	5427	22	to	to	TO
cord-006229-7yoilsho	5427	23	be	be	VB
cord-006229-7yoilsho	5427	24	evaluated	evaluate	VBN
cord-006229-7yoilsho	5427	25	.	.	.
cord-006229-7yoilsho	5428	1	During	during	IN
cord-006229-7yoilsho	5428	2	the	the	DT
cord-006229-7yoilsho	5428	3	years	year	NNS
cord-006229-7yoilsho	5428	4	an	an	DT
cord-006229-7yoilsho	5428	5	increasing	increase	VBG
cord-006229-7yoilsho	5428	6	amount	amount	NN
cord-006229-7yoilsho	5428	7	of	of	IN
cord-006229-7yoilsho	5428	8	substances	substance	NNS
cord-006229-7yoilsho	5428	9	as	as	RB
cord-006229-7yoilsho	5428	10	well	well	RB
cord-006229-7yoilsho	5428	11	as	as	IN
cord-006229-7yoilsho	5428	12	an	an	DT
cord-006229-7yoilsho	5428	13	increase	increase	NN
cord-006229-7yoilsho	5428	14	in	in	IN
cord-006229-7yoilsho	5428	15	finds	find	NNS
cord-006229-7yoilsho	5428	16	was	be	VBD
cord-006229-7yoilsho	5428	17	observed	observe	VBN
cord-006229-7yoilsho	5428	18	in	in	IN
cord-006229-7yoilsho	5428	19	drinking	drinking	NN
cord-006229-7yoilsho	5428	20	water	water	NN
cord-006229-7yoilsho	5428	21	.	.	.
cord-006229-7yoilsho	5429	1	This	this	DT
cord-006229-7yoilsho	5429	2	called	call	VBD
cord-006229-7yoilsho	5429	3	for	for	IN
cord-006229-7yoilsho	5429	4	the	the	DT
cord-006229-7yoilsho	5429	5	creation	creation	NN
cord-006229-7yoilsho	5429	6	of	of	IN
cord-006229-7yoilsho	5429	7	an	an	DT
cord-006229-7yoilsho	5429	8	evaluation	evaluation	NN
cord-006229-7yoilsho	5429	9	scheme	scheme	NN
cord-006229-7yoilsho	5429	10	that	that	WDT
cord-006229-7yoilsho	5429	11	offers	offer	VBZ
cord-006229-7yoilsho	5429	12	rapid	rapid	JJ
cord-006229-7yoilsho	5429	13	and	and	CC
cord-006229-7yoilsho	5429	14	at	at	IN
cord-006229-7yoilsho	5429	15	the	the	DT
cord-006229-7yoilsho	5429	16	same	same	JJ
cord-006229-7yoilsho	5429	17	time	time	NN
cord-006229-7yoilsho	5429	18	reliable	reliable	JJ
cord-006229-7yoilsho	5429	19	evaluations	evaluation	NNS
cord-006229-7yoilsho	5429	20	of	of	IN
cord-006229-7yoilsho	5429	21	chemicals	chemical	NNS
cord-006229-7yoilsho	5429	22	for	for	IN
cord-006229-7yoilsho	5429	23	which	which	WDT
cord-006229-7yoilsho	5429	24	there	there	EX
cord-006229-7yoilsho	5429	25	are	be	VBP
cord-006229-7yoilsho	5429	26	no	no	DT
cord-006229-7yoilsho	5429	27	data	data	NN
cord-006229-7yoilsho	5429	28	available	available	JJ
cord-006229-7yoilsho	5429	29	.	.	.
cord-006229-7yoilsho	5430	1	The	the	DT
cord-006229-7yoilsho	5430	2	concept	concept	NN
cord-006229-7yoilsho	5430	3	is	be	VBZ
cord-006229-7yoilsho	5430	4	in	in	IN
cord-006229-7yoilsho	5430	5	accordance	accordance	NN
cord-006229-7yoilsho	5430	6	with	with	IN
cord-006229-7yoilsho	5430	7	Tox21	Tox21	NNP
cord-006229-7yoilsho	5430	8	,	,	,
cord-006229-7yoilsho	5430	9	which	which	WDT
cord-006229-7yoilsho	5430	10	envisages	envisage	VBZ
cord-006229-7yoilsho	5430	11	the	the	DT
cord-006229-7yoilsho	5430	12	trustworthy	trustworthy	JJ
cord-006229-7yoilsho	5430	13	evaluation	evaluation	NN
cord-006229-7yoilsho	5430	14	of	of	IN
cord-006229-7yoilsho	5430	15	relevant	relevant	JJ
cord-006229-7yoilsho	5430	16	endpoints	endpoint	NNS
cord-006229-7yoilsho	5430	17	by	by	IN
cord-006229-7yoilsho	5430	18	two	two	CD
cord-006229-7yoilsho	5430	19	or	or	CC
cord-006229-7yoilsho	5430	20	three	three	CD
cord-006229-7yoilsho	5430	21	in	in	IN
cord-006229-7yoilsho	5430	22	vitro	vitro	FW
cord-006229-7yoilsho	5430	23	assays	assay	NNS
cord-006229-7yoilsho	5430	24	.	.	.
cord-006229-7yoilsho	5431	1	In	in	IN
cord-006229-7yoilsho	5431	2	the	the	DT
cord-006229-7yoilsho	5431	3	context	context	NN
cord-006229-7yoilsho	5431	4	of	of	IN
cord-006229-7yoilsho	5431	5	ToxBox	ToxBox	NNP
cord-006229-7yoilsho	5431	6	this	this	DT
cord-006229-7yoilsho	5431	7	was	be	VBD
cord-006229-7yoilsho	5431	8	provided	provide	VBN
cord-006229-7yoilsho	5431	9	for	for	IN
cord-006229-7yoilsho	5431	10	the	the	DT
cord-006229-7yoilsho	5431	11	endpoints	endpoint	NNS
cord-006229-7yoilsho	5431	12	genotoxicity	genotoxicity	NN
cord-006229-7yoilsho	5431	13	,	,	,
cord-006229-7yoilsho	5431	14	neurotoxicity	neurotoxicity	NN
cord-006229-7yoilsho	5431	15	and	and	CC
cord-006229-7yoilsho	5431	16	endocrine	endocrine	JJ
cord-006229-7yoilsho	5431	17	effects	effect	NNS
cord-006229-7yoilsho	5431	18	.	.	.
cord-006229-7yoilsho	5432	1	In	in	IN
cord-006229-7yoilsho	5432	2	all	all	DT
cord-006229-7yoilsho	5432	3	cases	case	NNS
cord-006229-7yoilsho	5432	4	a	a	DT
cord-006229-7yoilsho	5432	5	hierarchic	hierarchic	JJ
cord-006229-7yoilsho	5432	6	strategy	strategy	NN
cord-006229-7yoilsho	5432	7	is	be	VBZ
cord-006229-7yoilsho	5432	8	applied	apply	VBN
cord-006229-7yoilsho	5432	9	that	that	WDT
cord-006229-7yoilsho	5432	10	enables	enable	VBZ
cord-006229-7yoilsho	5432	11	a	a	DT
cord-006229-7yoilsho	5432	12	first	first	JJ
cord-006229-7yoilsho	5432	13	assessment	assessment	NN
cord-006229-7yoilsho	5432	14	via	via	IN
cord-006229-7yoilsho	5432	15	relatively	relatively	RB
cord-006229-7yoilsho	5432	16	simple	simple	JJ
cord-006229-7yoilsho	5432	17	test	test	NN
cord-006229-7yoilsho	5432	18	assays	assay	NNS
cord-006229-7yoilsho	5432	19	and	and	CC
cord-006229-7yoilsho	5432	20	only	only	RB
cord-006229-7yoilsho	5432	21	when	when	WRB
cord-006229-7yoilsho	5432	22	these	these	DT
cord-006229-7yoilsho	5432	23	test	test	NN
cord-006229-7yoilsho	5432	24	give	give	VBP
cord-006229-7yoilsho	5432	25	a	a	DT
cord-006229-7yoilsho	5432	26	hint	hint	NN
cord-006229-7yoilsho	5432	27	towards	towards	IN
cord-006229-7yoilsho	5432	28	an	an	DT
cord-006229-7yoilsho	5432	29	effective	effective	JJ
cord-006229-7yoilsho	5432	30	more	more	RBR
cord-006229-7yoilsho	5432	31	elaborate	elaborate	JJ
cord-006229-7yoilsho	5432	32	techniques	technique	NNS
cord-006229-7yoilsho	5432	33	are	be	VBP
cord-006229-7yoilsho	5432	34	applied	apply	VBN
cord-006229-7yoilsho	5432	35	for	for	IN
cord-006229-7yoilsho	5432	36	a	a	DT
cord-006229-7yoilsho	5432	37	final	final	JJ
cord-006229-7yoilsho	5432	38	assessment	assessment	NN
cord-006229-7yoilsho	5432	39	.	.	.
cord-006229-7yoilsho	5433	1	The	the	DT
cord-006229-7yoilsho	5433	2	Ames	Ames	NNP
cord-006229-7yoilsho	5433	3	test	test	NN
cord-006229-7yoilsho	5433	4	and	and	CC
cord-006229-7yoilsho	5433	5	micronucleus	micronucleus	NN
cord-006229-7yoilsho	5433	6	assay	assay	NN
cord-006229-7yoilsho	5433	7	in	in	IN
cord-006229-7yoilsho	5433	8	combination	combination	NN
cord-006229-7yoilsho	5433	9	with	with	IN
cord-006229-7yoilsho	5433	10	the	the	DT
cord-006229-7yoilsho	5433	11	Umu	Umu	NNP
cord-006229-7yoilsho	5433	12	test	test	NN
cord-006229-7yoilsho	5433	13	will	will	MD
cord-006229-7yoilsho	5433	14	form	form	VB
cord-006229-7yoilsho	5433	15	the	the	DT
cord-006229-7yoilsho	5433	16	panel	panel	NN
cord-006229-7yoilsho	5433	17	for	for	IN
cord-006229-7yoilsho	5433	18	genotoxicity	genotoxicity	NN
cord-006229-7yoilsho	5433	19	testing	testing	NN
cord-006229-7yoilsho	5433	20	.	.	.
cord-006229-7yoilsho	5434	1	Neurotoxicity	neurotoxicity	NN
cord-006229-7yoilsho	5434	2	will	will	MD
cord-006229-7yoilsho	5434	3	be	be	VB
cord-006229-7yoilsho	5434	4	assessed	assess	VBN
cord-006229-7yoilsho	5434	5	by	by	IN
cord-006229-7yoilsho	5434	6	comparing	compare	VBG
cord-006229-7yoilsho	5434	7	necrotic	necrotic	JJ
cord-006229-7yoilsho	5434	8	and	and	CC
cord-006229-7yoilsho	5434	9	apoptotic	apoptotic	JJ
cord-006229-7yoilsho	5434	10	effects	effect	NNS
cord-006229-7yoilsho	5434	11	as	as	RB
cord-006229-7yoilsho	5434	12	well	well	RB
cord-006229-7yoilsho	5434	13	as	as	IN
cord-006229-7yoilsho	5434	14	the	the	DT
cord-006229-7yoilsho	5434	15	development	development	NN
cord-006229-7yoilsho	5434	16	of	of	IN
cord-006229-7yoilsho	5434	17	reactive	reactive	JJ
cord-006229-7yoilsho	5434	18	oxygen	oxygen	NN
cord-006229-7yoilsho	5434	19	species	specie	NNS
cord-006229-7yoilsho	5434	20	in	in	IN
cord-006229-7yoilsho	5434	21	human	human	JJ
cord-006229-7yoilsho	5434	22	nervous	nervous	JJ
cord-006229-7yoilsho	5434	23	cell	cell	NN
cord-006229-7yoilsho	5434	24	with	with	IN
cord-006229-7yoilsho	5434	25	human	human	JJ
cord-006229-7yoilsho	5434	26	liver	liver	NN
cord-006229-7yoilsho	5434	27	cells	cell	NNS
cord-006229-7yoilsho	5434	28	.	.	.
cord-006229-7yoilsho	5435	1	Additionally	additionally	RB
cord-006229-7yoilsho	5435	2	neuron	neuron	NN
cord-006229-7yoilsho	5435	3	specific	specific	JJ
cord-006229-7yoilsho	5435	4	assay	assay	NN
cord-006229-7yoilsho	5435	5	like	like	IN
cord-006229-7yoilsho	5435	6	the	the	DT
cord-006229-7yoilsho	5435	7	Neurite	Neurite	NNP
cord-006229-7yoilsho	5435	8	Outgrowth	Outgrowth	NNP
cord-006229-7yoilsho	5435	9	Test	Test	NNP
cord-006229-7yoilsho	5435	10	are	be	VBP
cord-006229-7yoilsho	5435	11	performed	perform	VBN
cord-006229-7yoilsho	5435	12	.	.	.
cord-006229-7yoilsho	5436	1	This	this	DT
cord-006229-7yoilsho	5436	2	is	be	VBZ
cord-006229-7yoilsho	5436	3	complemented	complement	VBN
cord-006229-7yoilsho	5436	4	by	by	IN
cord-006229-7yoilsho	5436	5	measuring	measure	VBG
cord-006229-7yoilsho	5436	6	the	the	DT
cord-006229-7yoilsho	5436	7	activity	activity	NN
cord-006229-7yoilsho	5436	8	of	of	IN
cord-006229-7yoilsho	5436	9	acetyl	acetyl	NN
cord-006229-7yoilsho	5436	10	choline	choline	NN
cord-006229-7yoilsho	5436	11	esterase	esterase	NN
cord-006229-7yoilsho	5436	12	activity	activity	NN
cord-006229-7yoilsho	5436	13	and	and	CC
cord-006229-7yoilsho	5436	14	the	the	DT
cord-006229-7yoilsho	5436	15	development	development	NN
cord-006229-7yoilsho	5436	16	of	of	IN
cord-006229-7yoilsho	5436	17	the	the	DT
cord-006229-7yoilsho	5436	18	side	side	NN
cord-006229-7yoilsho	5436	19	line	line	NN
cord-006229-7yoilsho	5436	20	organ	organ	NN
cord-006229-7yoilsho	5436	21	in	in	IN
cord-006229-7yoilsho	5436	22	zebra	zebra	NN
cord-006229-7yoilsho	5436	23	fish	fish	NN
cord-006229-7yoilsho	5436	24	(	(	-LRB-
cord-006229-7yoilsho	5436	25	Danio	Danio	NNP
cord-006229-7yoilsho	5436	26	rerio	rerio	NNP
cord-006229-7yoilsho	5436	27	)	)	-RRB-
cord-006229-7yoilsho	5436	28	.	.	.
cord-006229-7yoilsho	5437	1	The	the	DT
cord-006229-7yoilsho	5437	2	test	test	NN
cord-006229-7yoilsho	5437	3	battery	battery	NN
cord-006229-7yoilsho	5437	4	for	for	IN
cord-006229-7yoilsho	5437	5	endocrine	endocrine	JJ
cord-006229-7yoilsho	5437	6	effects	effect	NNS
cord-006229-7yoilsho	5437	7	consists	consist	VBZ
cord-006229-7yoilsho	5437	8	of	of	IN
cord-006229-7yoilsho	5437	9	hormone	hormone	NN
cord-006229-7yoilsho	5437	10	specific	specific	JJ
cord-006229-7yoilsho	5437	11	reporter	reporter	NN
cord-006229-7yoilsho	5437	12	gene	gene	NN
cord-006229-7yoilsho	5437	13	S81	s81	JJ
cord-006229-7yoilsho	5437	14	assays	assay	NNS
cord-006229-7yoilsho	5437	15	in	in	IN
cord-006229-7yoilsho	5437	16	addition	addition	NN
cord-006229-7yoilsho	5437	17	to	to	IN
cord-006229-7yoilsho	5437	18	the	the	DT
cord-006229-7yoilsho	5437	19	H295R	H295R	NNP
cord-006229-7yoilsho	5437	20	assay	assay	NN
cord-006229-7yoilsho	5437	21	.	.	.
cord-006229-7yoilsho	5438	1	When	when	WRB
cord-006229-7yoilsho	5438	2	necessary	necessary	JJ
cord-006229-7yoilsho	5438	3	a	a	DT
cord-006229-7yoilsho	5438	4	reproduction	reproduction	NN
cord-006229-7yoilsho	5438	5	assay	assay	NN
cord-006229-7yoilsho	5438	6	in	in	IN
cord-006229-7yoilsho	5438	7	the	the	DT
cord-006229-7yoilsho	5438	8	mud	mud	NN
cord-006229-7yoilsho	5438	9	snail	snail	NN
cord-006229-7yoilsho	5439	1	Potamopyrgus	Potamopyrgus	NNP
cord-006229-7yoilsho	5439	2	antipodarum	antipodarum	NNP
cord-006229-7yoilsho	5439	3	is	be	VBZ
cord-006229-7yoilsho	5439	4	carried	carry	VBN
cord-006229-7yoilsho	5439	5	out	out	RP
cord-006229-7yoilsho	5439	6	.	.	.
cord-006229-7yoilsho	5440	1	During	during	IN
cord-006229-7yoilsho	5440	2	the	the	DT
cord-006229-7yoilsho	5440	3	project	project	NN
cord-006229-7yoilsho	5440	4	some	some	DT
cord-006229-7yoilsho	5440	5	60	60	CD
cord-006229-7yoilsho	5440	6	substances	substance	NNS
cord-006229-7yoilsho	5440	7	were	be	VBD
cord-006229-7yoilsho	5440	8	evaluated	evaluate	VBN
cord-006229-7yoilsho	5440	9	.	.	.
cord-006229-7yoilsho	5441	1	This	this	DT
cord-006229-7yoilsho	5441	2	allowed	allow	VBD
cord-006229-7yoilsho	5441	3	for	for	IN
cord-006229-7yoilsho	5441	4	the	the	DT
cord-006229-7yoilsho	5441	5	development	development	NN
cord-006229-7yoilsho	5441	6	of	of	IN
cord-006229-7yoilsho	5441	7	a	a	DT
cord-006229-7yoilsho	5441	8	reliable	reliable	JJ
cord-006229-7yoilsho	5441	9	test	test	NN
cord-006229-7yoilsho	5441	10	strategy	strategy	NN
cord-006229-7yoilsho	5441	11	.	.	.
cord-006229-7yoilsho	5442	1	Currently	currently	RB
cord-006229-7yoilsho	5442	2	the	the	DT
cord-006229-7yoilsho	5442	3	guidelines	guideline	NNS
cord-006229-7yoilsho	5442	4	for	for	IN
cord-006229-7yoilsho	5442	5	performing	perform	VBG
cord-006229-7yoilsho	5442	6	the	the	DT
cord-006229-7yoilsho	5442	7	required	require	VBN
cord-006229-7yoilsho	5442	8	tests	test	NNS
cord-006229-7yoilsho	5442	9	are	be	VBP
cord-006229-7yoilsho	5442	10	in	in	IN
cord-006229-7yoilsho	5442	11	the	the	DT
cord-006229-7yoilsho	5442	12	making	making	NN
cord-006229-7yoilsho	5442	13	.	.	.
cord-006229-7yoilsho	5443	1	Metabolomics	Metabolomics	NNP
cord-006229-7yoilsho	5443	2	has	have	VBZ
cord-006229-7yoilsho	5443	3	gained	gain	VBN
cord-006229-7yoilsho	5443	4	increasing	increase	VBG
cord-006229-7yoilsho	5443	5	interest	interest	NN
cord-006229-7yoilsho	5443	6	over	over	IN
cord-006229-7yoilsho	5443	7	the	the	DT
cord-006229-7yoilsho	5443	8	last	last	JJ
cord-006229-7yoilsho	5443	9	years	year	NNS
cord-006229-7yoilsho	5443	10	with	with	IN
cord-006229-7yoilsho	5443	11	numerous	numerous	JJ
cord-006229-7yoilsho	5443	12	possible	possible	JJ
cord-006229-7yoilsho	5443	13	applications	application	NNS
cord-006229-7yoilsho	5443	14	ranging	range	VBG
cord-006229-7yoilsho	5443	15	from	from	IN
cord-006229-7yoilsho	5443	16	strain	strain	NN
cord-006229-7yoilsho	5443	17	optimization	optimization	NN
cord-006229-7yoilsho	5443	18	for	for	IN
cord-006229-7yoilsho	5443	19	industrial	industrial	JJ
cord-006229-7yoilsho	5443	20	production	production	NN
cord-006229-7yoilsho	5443	21	over	over	IN
cord-006229-7yoilsho	5443	22	drug	drug	NN
cord-006229-7yoilsho	5443	23	discovery	discovery	NN
cord-006229-7yoilsho	5443	24	to	to	IN
cord-006229-7yoilsho	5443	25	improved	improve	VBN
cord-006229-7yoilsho	5443	26	toxicity	toxicity	NN
cord-006229-7yoilsho	5443	27	testing	testing	NN
cord-006229-7yoilsho	5443	28	.	.	.
cord-006229-7yoilsho	5444	1	However	however	RB
cord-006229-7yoilsho	5444	2	,	,	,
cord-006229-7yoilsho	5444	3	regulatory	regulatory	JJ
cord-006229-7yoilsho	5444	4	acceptance	acceptance	NN
cord-006229-7yoilsho	5444	5	of	of	IN
cord-006229-7yoilsho	5444	6	this	this	DT
cord-006229-7yoilsho	5444	7	promising	promising	JJ
cord-006229-7yoilsho	5444	8	approach	approach	NN
cord-006229-7yoilsho	5444	9	is	be	VBZ
cord-006229-7yoilsho	5444	10	still	still	RB
cord-006229-7yoilsho	5444	11	not	not	RB
cord-006229-7yoilsho	5444	12	reached	reach	VBN
cord-006229-7yoilsho	5444	13	,	,	,
cord-006229-7yoilsho	5444	14	mostly	mostly	RB
cord-006229-7yoilsho	5444	15	because	because	IN
cord-006229-7yoilsho	5444	16	standardization	standardization	NN
cord-006229-7yoilsho	5444	17	and	and	CC
cord-006229-7yoilsho	5444	18	evaluation	evaluation	NN
cord-006229-7yoilsho	5444	19	of	of	IN
cord-006229-7yoilsho	5444	20	reproducibility	reproducibility	NN
cord-006229-7yoilsho	5444	21	are	be	VBP
cord-006229-7yoilsho	5444	22	still	still	RB
cord-006229-7yoilsho	5444	23	mostly	mostly	RB
cord-006229-7yoilsho	5444	24	lacking	lacking	JJ
cord-006229-7yoilsho	5444	25	.	.	.
cord-006229-7yoilsho	5445	1	The	the	DT
cord-006229-7yoilsho	5445	2	MetaMap	MetaMap	NNP
cord-006229-7yoilsho	5445	3	®	®	NN
cord-006229-7yoilsho	5445	4	Tox	Tox	NNP
cord-006229-7yoilsho	5445	5	database	database	NN
cord-006229-7yoilsho	5445	6	has	have	VBZ
cord-006229-7yoilsho	5445	7	been	be	VBN
cord-006229-7yoilsho	5445	8	developed	develop	VBN
cord-006229-7yoilsho	5445	9	by	by	IN
cord-006229-7yoilsho	5445	10	BASF	BASF	NNP
cord-006229-7yoilsho	5445	11	over	over	IN
cord-006229-7yoilsho	5445	12	the	the	DT
cord-006229-7yoilsho	5445	13	last	last	JJ
cord-006229-7yoilsho	5445	14	ten	ten	CD
cord-006229-7yoilsho	5445	15	years	year	NNS
cord-006229-7yoilsho	5445	16	containing	contain	VBG
cord-006229-7yoilsho	5445	17	toxicity	toxicity	NN
cord-006229-7yoilsho	5445	18	and	and	CC
cord-006229-7yoilsho	5445	19	metabolome	metabolome	NN
cord-006229-7yoilsho	5445	20	profiles	profile	NNS
cord-006229-7yoilsho	5445	21	of	of	IN
cord-006229-7yoilsho	5445	22	more	more	JJR
cord-006229-7yoilsho	5445	23	than	than	IN
cord-006229-7yoilsho	5445	24	750	750	CD
cord-006229-7yoilsho	5445	25	different	different	JJ
cord-006229-7yoilsho	5445	26	compounds	compound	NNS
cord-006229-7yoilsho	5445	27	.	.	.
cord-006229-7yoilsho	5446	1	To	to	TO
cord-006229-7yoilsho	5446	2	ensure	ensure	VB
cord-006229-7yoilsho	5446	3	maximum	maximum	JJ
cord-006229-7yoilsho	5446	4	reliability	reliability	NN
cord-006229-7yoilsho	5446	5	,	,	,
cord-006229-7yoilsho	5446	6	data	datum	NNS
cord-006229-7yoilsho	5446	7	was	be	VBD
cord-006229-7yoilsho	5446	8	gained	gain	VBN
cord-006229-7yoilsho	5446	9	from	from	IN
cord-006229-7yoilsho	5446	10	plasma	plasma	NN
cord-006229-7yoilsho	5446	11	samples	sample	NNS
cord-006229-7yoilsho	5446	12	of	of	IN
cord-006229-7yoilsho	5446	13	highly	highly	RB
cord-006229-7yoilsho	5446	14	standardized	standardized	JJ
cord-006229-7yoilsho	5446	15	4	4	CD
cord-006229-7yoilsho	5446	16	week	week	NN
cord-006229-7yoilsho	5446	17	rat	rat	NN
cord-006229-7yoilsho	5446	18	studies	study	NNS
cord-006229-7yoilsho	5446	19	.	.	.
cord-006229-7yoilsho	5447	1	Animal	animal	NN
cord-006229-7yoilsho	5447	2	maintenance	maintenance	NN
cord-006229-7yoilsho	5447	3	and	and	CC
cord-006229-7yoilsho	5447	4	treatment	treatment	NN
cord-006229-7yoilsho	5447	5	,	,	,
cord-006229-7yoilsho	5447	6	sampling	sampling	NN
cord-006229-7yoilsho	5447	7	and	and	CC
cord-006229-7yoilsho	5447	8	work	work	NN
cord-006229-7yoilsho	5447	9	-	-	HYPH
cord-006229-7yoilsho	5447	10	up	up	NN
cord-006229-7yoilsho	5447	11	of	of	IN
cord-006229-7yoilsho	5447	12	plasma	plasma	NN
cord-006229-7yoilsho	5447	13	,	,	,
cord-006229-7yoilsho	5447	14	measurement	measurement	NN
cord-006229-7yoilsho	5447	15	of	of	IN
cord-006229-7yoilsho	5447	16	the	the	DT
cord-006229-7yoilsho	5447	17	metabolome	metabolome	NN
cord-006229-7yoilsho	5447	18	as	as	RB
cord-006229-7yoilsho	5447	19	well	well	RB
cord-006229-7yoilsho	5447	20	as	as	IN
cord-006229-7yoilsho	5447	21	data	datum	NNS
cord-006229-7yoilsho	5447	22	interpretation	interpretation	NN
cord-006229-7yoilsho	5447	23	and	and	CC
cord-006229-7yoilsho	5447	24	storage	storage	NN
cord-006229-7yoilsho	5447	25	were	be	VBD
cord-006229-7yoilsho	5447	26	standardized	standardize	VBN
cord-006229-7yoilsho	5447	27	including	include	VBG
cord-006229-7yoilsho	5447	28	thorough	thorough	JJ
cord-006229-7yoilsho	5447	29	documentation	documentation	NN
cord-006229-7yoilsho	5447	30	,	,	,
cord-006229-7yoilsho	5447	31	the	the	DT
cord-006229-7yoilsho	5447	32	compliance	compliance	NN
cord-006229-7yoilsho	5447	33	with	with	IN
cord-006229-7yoilsho	5447	34	SOPs	sop	NNS
cord-006229-7yoilsho	5447	35	and	and	CC
cord-006229-7yoilsho	5447	36	safe	safe	JJ
cord-006229-7yoilsho	5447	37	data	datum	NNS
cord-006229-7yoilsho	5447	38	storage	storage	NN
cord-006229-7yoilsho	5447	39	.	.	.
cord-006229-7yoilsho	5448	1	Data	datum	NNS
cord-006229-7yoilsho	5448	2	from	from	IN
cord-006229-7yoilsho	5448	3	more	more	JJR
cord-006229-7yoilsho	5448	4	than	than	IN
cord-006229-7yoilsho	5448	5	80	80	CD
cord-006229-7yoilsho	5448	6	control	control	NN
cord-006229-7yoilsho	5448	7	groups	group	NNS
cord-006229-7yoilsho	5448	8	with	with	IN
cord-006229-7yoilsho	5448	9	each	each	DT
cord-006229-7yoilsho	5448	10	10	10	CD
cord-006229-7yoilsho	5448	11	males	male	NNS
cord-006229-7yoilsho	5448	12	and	and	CC
cord-006229-7yoilsho	5448	13	females	female	NNS
cord-006229-7yoilsho	5448	14	were	be	VBD
cord-006229-7yoilsho	5448	15	analyzed	analyze	VBN
cord-006229-7yoilsho	5448	16	to	to	TO
cord-006229-7yoilsho	5448	17	assess	assess	VB
cord-006229-7yoilsho	5448	18	variability	variability	NN
cord-006229-7yoilsho	5448	19	.	.	.
cord-006229-7yoilsho	5449	1	An	an	DT
cord-006229-7yoilsho	5449	2	in	in	IN
cord-006229-7yoilsho	5449	3	depth	depth	NN
cord-006229-7yoilsho	5449	4	analysis	analysis	NN
cord-006229-7yoilsho	5449	5	of	of	IN
cord-006229-7yoilsho	5449	6	this	this	DT
cord-006229-7yoilsho	5449	7	showed	show	VBD
cord-006229-7yoilsho	5449	8	a	a	DT
cord-006229-7yoilsho	5449	9	high	high	JJ
cord-006229-7yoilsho	5449	10	stability	stability	NN
cord-006229-7yoilsho	5449	11	and	and	CC
cord-006229-7yoilsho	5449	12	robustness	robustness	NN
cord-006229-7yoilsho	5449	13	of	of	IN
cord-006229-7yoilsho	5449	14	the	the	DT
cord-006229-7yoilsho	5449	15	metabolome	metabolome	NN
cord-006229-7yoilsho	5449	16	over	over	IN
cord-006229-7yoilsho	5449	17	a	a	DT
cord-006229-7yoilsho	5449	18	period	period	NN
cord-006229-7yoilsho	5449	19	of	of	IN
cord-006229-7yoilsho	5449	20	ten	ten	CD
cord-006229-7yoilsho	5449	21	years	year	NNS
cord-006229-7yoilsho	5449	22	.	.	.
cord-006229-7yoilsho	5450	1	After	after	IN
cord-006229-7yoilsho	5450	2	artificially	artificially	RB
cord-006229-7yoilsho	5450	3	splitting	split	VBG
cord-006229-7yoilsho	5450	4	the	the	DT
cord-006229-7yoilsho	5450	5	groups	group	NNS
cord-006229-7yoilsho	5450	6	of	of	IN
cord-006229-7yoilsho	5450	7	10	10	CD
cord-006229-7yoilsho	5450	8	control	control	NN
cord-006229-7yoilsho	5450	9	groups	group	NNS
cord-006229-7yoilsho	5450	10	into	into	IN
cord-006229-7yoilsho	5450	11	groups	group	NNS
cord-006229-7yoilsho	5450	12	of	of	IN
cord-006229-7yoilsho	5450	13	five	five	CD
cord-006229-7yoilsho	5450	14	animals	animal	NNS
cord-006229-7yoilsho	5450	15	and	and	CC
cord-006229-7yoilsho	5450	16	comparing	compare	VBG
cord-006229-7yoilsho	5450	17	the	the	DT
cord-006229-7yoilsho	5450	18	number	number	NN
cord-006229-7yoilsho	5450	19	of	of	IN
cord-006229-7yoilsho	5450	20	statistically	statistically	RB
cord-006229-7yoilsho	5450	21	significantly	significantly	RB
cord-006229-7yoilsho	5450	22	regulated	regulate	VBN
cord-006229-7yoilsho	5450	23	(	(	-LRB-
cord-006229-7yoilsho	5450	24	false	false	JJ
cord-006229-7yoilsho	5450	25	positive	positive	JJ
cord-006229-7yoilsho	5450	26	)	)	-RRB-
cord-006229-7yoilsho	5450	27	metabolites	metabolite	NNS
cord-006229-7yoilsho	5450	28	,	,	,
cord-006229-7yoilsho	5450	29	the	the	DT
cord-006229-7yoilsho	5450	30	peak	peak	NN
cord-006229-7yoilsho	5450	31	of	of	IN
cord-006229-7yoilsho	5450	32	the	the	DT
cord-006229-7yoilsho	5450	33	distribution	distribution	NN
cord-006229-7yoilsho	5450	34	curve	curve	NN
cord-006229-7yoilsho	5450	35	was	be	VBD
cord-006229-7yoilsho	5450	36	located	locate	VBN
cord-006229-7yoilsho	5450	37	to	to	IN
cord-006229-7yoilsho	5450	38	the	the	DT
cord-006229-7yoilsho	5450	39	left	left	NN
cord-006229-7yoilsho	5450	40	of	of	IN
cord-006229-7yoilsho	5450	41	the	the	DT
cord-006229-7yoilsho	5450	42	exact	exact	JJ
cord-006229-7yoilsho	5450	43	(	(	-LRB-
cord-006229-7yoilsho	5450	44	gaussian	gaussian	NNP
cord-006229-7yoilsho	5450	45	)	)	-RRB-
cord-006229-7yoilsho	5450	46	center	center	NN
cord-006229-7yoilsho	5450	47	,	,	,
cord-006229-7yoilsho	5450	48	but	but	CC
cord-006229-7yoilsho	5450	49	tailed	tail	VBN
cord-006229-7yoilsho	5450	50	off	off	RP
cord-006229-7yoilsho	5450	51	to	to	IN
cord-006229-7yoilsho	5450	52	the	the	DT
cord-006229-7yoilsho	5450	53	right	right	NN
cord-006229-7yoilsho	5450	54	more	more	JJR
cord-006229-7yoilsho	5450	55	than	than	IN
cord-006229-7yoilsho	5450	56	expected	expect	VBN
cord-006229-7yoilsho	5450	57	under	under	IN
cord-006229-7yoilsho	5450	58	the	the	DT
cord-006229-7yoilsho	5450	59	normal	normal	JJ
cord-006229-7yoilsho	5450	60	distribution	distribution	NN
cord-006229-7yoilsho	5450	61	.	.	.
cord-006229-7yoilsho	5451	1	From	from	IN
cord-006229-7yoilsho	5451	2	this	this	DT
cord-006229-7yoilsho	5451	3	analysis	analysis	NN
cord-006229-7yoilsho	5451	4	we	-PRON-	PRP
cord-006229-7yoilsho	5451	5	were	be	VBD
cord-006229-7yoilsho	5451	6	able	able	JJ
cord-006229-7yoilsho	5451	7	to	to	TO
cord-006229-7yoilsho	5451	8	calculate	calculate	VB
cord-006229-7yoilsho	5451	9	density	density	NN
cord-006229-7yoilsho	5451	10	distributions	distribution	NNS
cord-006229-7yoilsho	5451	11	(	(	-LRB-
cord-006229-7yoilsho	5451	12	relative	relative	JJ
cord-006229-7yoilsho	5451	13	ratio	ratio	NN
cord-006229-7yoilsho	5451	14	and	and	CC
cord-006229-7yoilsho	5451	15	standard	standard	JJ
cord-006229-7yoilsho	5451	16	deviation	deviation	NN
cord-006229-7yoilsho	5451	17	)	)	-RRB-
cord-006229-7yoilsho	5451	18	for	for	IN
cord-006229-7yoilsho	5451	19	the	the	DT
cord-006229-7yoilsho	5451	20	control	control	NN
cord-006229-7yoilsho	5451	21	values	value	NNS
cord-006229-7yoilsho	5451	22	of	of	IN
cord-006229-7yoilsho	5451	23	each	each	DT
cord-006229-7yoilsho	5451	24	metabolite	metabolite	NN
cord-006229-7yoilsho	5451	25	,	,	,
cord-006229-7yoilsho	5451	26	which	which	WDT
cord-006229-7yoilsho	5451	27	can	can	MD
cord-006229-7yoilsho	5451	28	serve	serve	VB
cord-006229-7yoilsho	5451	29	as	as	IN
cord-006229-7yoilsho	5451	30	a	a	DT
cord-006229-7yoilsho	5451	31	historical	historical	JJ
cord-006229-7yoilsho	5451	32	control	control	NN
cord-006229-7yoilsho	5451	33	displaying	display	VBG
cord-006229-7yoilsho	5451	34	the	the	DT
cord-006229-7yoilsho	5451	35	range	range	NN
cord-006229-7yoilsho	5451	36	of	of	IN
cord-006229-7yoilsho	5451	37	changes	change	NNS
cord-006229-7yoilsho	5451	38	which	which	WDT
cord-006229-7yoilsho	5451	39	can	can	MD
cord-006229-7yoilsho	5451	40	be	be	VB
cord-006229-7yoilsho	5451	41	expected	expect	VBN
cord-006229-7yoilsho	5451	42	as	as	IN
cord-006229-7yoilsho	5451	43	normal	normal	JJ
cord-006229-7yoilsho	5451	44	.	.	.
cord-006229-7yoilsho	5452	1	During	during	IN
cord-006229-7yoilsho	5452	2	the	the	DT
cord-006229-7yoilsho	5452	3	course	course	NN
cord-006229-7yoilsho	5452	4	of	of	IN
cord-006229-7yoilsho	5452	5	our	-PRON-	PRP$
cord-006229-7yoilsho	5452	6	project	project	NN
cord-006229-7yoilsho	5452	7	we	-PRON-	PRP
cord-006229-7yoilsho	5452	8	have	have	VBP
cord-006229-7yoilsho	5452	9	used	use	VBN
cord-006229-7yoilsho	5452	10	more	more	JJR
cord-006229-7yoilsho	5452	11	than	than	IN
cord-006229-7yoilsho	5452	12	ten	ten	CD
cord-006229-7yoilsho	5452	13	exact	exact	NN
cord-006229-7yoilsho	5452	14	repeats	repeat	NNS
cord-006229-7yoilsho	5452	15	to	to	TO
cord-006229-7yoilsho	5452	16	show	show	VB
cord-006229-7yoilsho	5452	17	reproducibility	reproducibility	NN
cord-006229-7yoilsho	5452	18	and	and	CC
cord-006229-7yoilsho	5452	19	reliability	reliability	NN
cord-006229-7yoilsho	5452	20	of	of	IN
cord-006229-7yoilsho	5452	21	the	the	DT
cord-006229-7yoilsho	5452	22	metabolome	metabolome	NNP
cord-006229-7yoilsho	5452	23	analysis	analysis	NNP
cord-006229-7yoilsho	5453	1	(	(	-LRB-
cord-006229-7yoilsho	5453	2	Kamp	Kamp	NNP
cord-006229-7yoilsho	5453	3	et	et	NNP
cord-006229-7yoilsho	5453	4	al	al	NNP
cord-006229-7yoilsho	5453	5	.	.	NNP
cord-006229-7yoilsho	5453	6	,	,	,
cord-006229-7yoilsho	5453	7	2012	2012	CD
cord-006229-7yoilsho	5453	8	)	)	-RRB-
cord-006229-7yoilsho	5453	9	.	.	.
cord-006229-7yoilsho	5454	1	Comparing	compare	VBG
cord-006229-7yoilsho	5454	2	these	these	DT
cord-006229-7yoilsho	5454	3	exact	exact	JJ
cord-006229-7yoilsho	5454	4	repeats	repeat	NNS
cord-006229-7yoilsho	5454	5	at	at	IN
cord-006229-7yoilsho	5454	6	different	different	JJ
cord-006229-7yoilsho	5454	7	levels	level	NNS
cord-006229-7yoilsho	5454	8	of	of	IN
cord-006229-7yoilsho	5454	9	statistical	statistical	JJ
cord-006229-7yoilsho	5454	10	significance	significance	NN
cord-006229-7yoilsho	5454	11	,	,	,
cord-006229-7yoilsho	5454	12	we	-PRON-	PRP
cord-006229-7yoilsho	5454	13	noted	note	VBD
cord-006229-7yoilsho	5454	14	that	that	IN
cord-006229-7yoilsho	5454	15	at	at	IN
cord-006229-7yoilsho	5454	16	a	a	DT
cord-006229-7yoilsho	5454	17	level	level	NN
cord-006229-7yoilsho	5454	18	of	of	IN
cord-006229-7yoilsho	5454	19	statistical	statistical	JJ
cord-006229-7yoilsho	5454	20	significance	significance	NN
cord-006229-7yoilsho	5454	21	of	of	IN
cord-006229-7yoilsho	5454	22	approximately	approximately	RB
cord-006229-7yoilsho	5454	23	p	p	NN
cord-006229-7yoilsho	5454	24	=	=	SYM
cord-006229-7yoilsho	5454	25	0.1	0.1	CD
cord-006229-7yoilsho	5454	26	,	,	,
cord-006229-7yoilsho	5454	27	the	the	DT
cord-006229-7yoilsho	5454	28	best	good	JJS
cord-006229-7yoilsho	5454	29	balance	balance	NN
cord-006229-7yoilsho	5454	30	between	between	IN
cord-006229-7yoilsho	5454	31	matches	match	NNS
cord-006229-7yoilsho	5454	32	(	(	-LRB-
cord-006229-7yoilsho	5454	33	metabolites	metabolite	NNS
cord-006229-7yoilsho	5454	34	regulated	regulate	VBN
cord-006229-7yoilsho	5454	35	in	in	IN
cord-006229-7yoilsho	5454	36	the	the	DT
cord-006229-7yoilsho	5454	37	same	same	JJ
cord-006229-7yoilsho	5454	38	direction	direction	NN
cord-006229-7yoilsho	5454	39	)	)	-RRB-
cord-006229-7yoilsho	5454	40	and	and	CC
cord-006229-7yoilsho	5454	41	mismatches	mismatch	NNS
cord-006229-7yoilsho	5454	42	(	(	-LRB-
cord-006229-7yoilsho	5454	43	metabolites	metabolite	NNS
cord-006229-7yoilsho	5454	44	regulated	regulate	VBN
cord-006229-7yoilsho	5454	45	in	in	IN
cord-006229-7yoilsho	5454	46	opposite	opposite	JJ
cord-006229-7yoilsho	5454	47	directions	direction	NNS
cord-006229-7yoilsho	5454	48	)	)	-RRB-
cord-006229-7yoilsho	5454	49	was	be	VBD
cord-006229-7yoilsho	5454	50	obtained	obtain	VBN
cord-006229-7yoilsho	5454	51	.	.	.
cord-006229-7yoilsho	5455	1	The	the	DT
cord-006229-7yoilsho	5455	2	high	high	JJ
cord-006229-7yoilsho	5455	3	quality	quality	NN
cord-006229-7yoilsho	5455	4	standards	standard	NNS
cord-006229-7yoilsho	5455	5	applied	apply	VBN
cord-006229-7yoilsho	5455	6	as	as	RB
cord-006229-7yoilsho	5455	7	well	well	RB
cord-006229-7yoilsho	5455	8	as	as	IN
cord-006229-7yoilsho	5455	9	the	the	DT
cord-006229-7yoilsho	5455	10	examination	examination	NN
cord-006229-7yoilsho	5455	11	of	of	IN
cord-006229-7yoilsho	5455	12	control	control	NN
cord-006229-7yoilsho	5455	13	data	datum	NNS
cord-006229-7yoilsho	5455	14	increase	increase	VBP
cord-006229-7yoilsho	5455	15	the	the	DT
cord-006229-7yoilsho	5455	16	robustness	robustness	NN
cord-006229-7yoilsho	5455	17	of	of	IN
cord-006229-7yoilsho	5455	18	this	this	DT
cord-006229-7yoilsho	5455	19	approach	approach	NN
cord-006229-7yoilsho	5455	20	,	,	,
cord-006229-7yoilsho	5455	21	going	go	VBG
cord-006229-7yoilsho	5455	22	also	also	RB
cord-006229-7yoilsho	5455	23	hand	hand	VBP
cord-006229-7yoilsho	5455	24	in	in	IN
cord-006229-7yoilsho	5455	25	hand	hand	NN
cord-006229-7yoilsho	5455	26	with	with	IN
cord-006229-7yoilsho	5455	27	improved	improved	JJ
cord-006229-7yoilsho	5455	28	data	data	NN
cord-006229-7yoilsho	5455	29	quality	quality	NN
cord-006229-7yoilsho	5455	30	.	.	.
cord-006229-7yoilsho	5456	1	This	this	DT
cord-006229-7yoilsho	5456	2	significantly	significantly	RB
cord-006229-7yoilsho	5456	3	facilitates	facilitate	VBZ
cord-006229-7yoilsho	5456	4	decision	decision	NN
cord-006229-7yoilsho	5456	5	making	make	VBG
cord-006229-7yoilsho	5456	6	based	base	VBN
cord-006229-7yoilsho	5456	7	on	on	IN
cord-006229-7yoilsho	5456	8	the	the	DT
cord-006229-7yoilsho	5456	9	gained	gain	VBN
cord-006229-7yoilsho	5456	10	data	datum	NNS
cord-006229-7yoilsho	5456	11	.	.	.
cord-006229-7yoilsho	5457	1	Due	due	IN
cord-006229-7yoilsho	5457	2	to	to	IN
cord-006229-7yoilsho	5457	3	these	these	DT
cord-006229-7yoilsho	5457	4	improvements	improvement	NNS
cord-006229-7yoilsho	5457	5	a	a	DT
cord-006229-7yoilsho	5457	6	new	new	JJ
cord-006229-7yoilsho	5457	7	level	level	NN
cord-006229-7yoilsho	5457	8	of	of	IN
cord-006229-7yoilsho	5457	9	transparency	transparency	NN
cord-006229-7yoilsho	5457	10	is	be	VBZ
cord-006229-7yoilsho	5457	11	reached	reach	VBN
cord-006229-7yoilsho	5457	12	,	,	,
cord-006229-7yoilsho	5457	13	which	which	WDT
cord-006229-7yoilsho	5457	14	might	may	MD
cord-006229-7yoilsho	5457	15	allow	allow	VB
cord-006229-7yoilsho	5457	16	inclusion	inclusion	NN
cord-006229-7yoilsho	5457	17	of	of	IN
cord-006229-7yoilsho	5457	18	metabolome	metabolome	NNP
cord-006229-7yoilsho	5457	19	data	datum	NNS
cord-006229-7yoilsho	5457	20	in	in	IN
cord-006229-7yoilsho	5457	21	a	a	DT
cord-006229-7yoilsho	5457	22	regulatory	regulatory	JJ
cord-006229-7yoilsho	5457	23	environment	environment	NN
cord-006229-7yoilsho	5457	24	.	.	.
cord-006229-7yoilsho	5458	1	Hydroxycitric	Hydroxycitric	NNP
cord-006229-7yoilsho	5458	2	acid	acid	NN
cord-006229-7yoilsho	5458	3	(	(	-LRB-
cord-006229-7yoilsho	5458	4	HCA	HCA	NNP
cord-006229-7yoilsho	5458	5	)	)	-RRB-
cord-006229-7yoilsho	5458	6	is	be	VBZ
cord-006229-7yoilsho	5458	7	a	a	DT
cord-006229-7yoilsho	5458	8	fruit	fruit	NN
cord-006229-7yoilsho	5458	9	acid	acid	NN
cord-006229-7yoilsho	5458	10	naturally	naturally	RB
cord-006229-7yoilsho	5458	11	occurring	occur	VBG
cord-006229-7yoilsho	5458	12	in	in	IN
cord-006229-7yoilsho	5458	13	fruits	fruit	NNS
cord-006229-7yoilsho	5458	14	of	of	IN
cord-006229-7yoilsho	5458	15	the	the	DT
cord-006229-7yoilsho	5458	16	tropical	tropical	JJ
cord-006229-7yoilsho	5458	17	plant	plant	NN
cord-006229-7yoilsho	5458	18	Garcinia	Garcinia	NNP
cord-006229-7yoilsho	5458	19	cambogia	cambogia	NN
cord-006229-7yoilsho	5458	20	.	.	.
cord-006229-7yoilsho	5459	1	A	a	DT
cord-006229-7yoilsho	5459	2	number	number	NN
cord-006229-7yoilsho	5459	3	of	of	IN
cord-006229-7yoilsho	5459	4	dietary	dietary	JJ
cord-006229-7yoilsho	5459	5	supplements	supplement	NNS
cord-006229-7yoilsho	5459	6	intended	intend	VBN
cord-006229-7yoilsho	5459	7	for	for	IN
cord-006229-7yoilsho	5459	8	weight	weight	NN
cord-006229-7yoilsho	5459	9	loss	loss	NN
cord-006229-7yoilsho	5459	10	contain	contain	VBP
cord-006229-7yoilsho	5459	11	HCA	HCA	NNP
cord-006229-7yoilsho	5459	12	,	,	,
cord-006229-7yoilsho	5459	13	which	which	WDT
cord-006229-7yoilsho	5459	14	is	be	VBZ
cord-006229-7yoilsho	5459	15	added	add	VBN
cord-006229-7yoilsho	5459	16	in	in	IN
cord-006229-7yoilsho	5459	17	form	form	NN
cord-006229-7yoilsho	5459	18	of	of	IN
cord-006229-7yoilsho	5459	19	G.	G.	NNP
cord-006229-7yoilsho	5459	20	cambogia	cambogia	NN
cord-006229-7yoilsho	5459	21	extracts	extract	NNS
cord-006229-7yoilsho	5459	22	.	.	.
cord-006229-7yoilsho	5460	1	The	the	DT
cord-006229-7yoilsho	5460	2	composition	composition	NN
cord-006229-7yoilsho	5460	3	of	of	IN
cord-006229-7yoilsho	5460	4	these	these	DT
cord-006229-7yoilsho	5460	5	extracts	extract	NNS
cord-006229-7yoilsho	5460	6	is	be	VBZ
cord-006229-7yoilsho	5460	7	often	often	RB
cord-006229-7yoilsho	5460	8	not	not	RB
cord-006229-7yoilsho	5460	9	clearly	clearly	RB
cord-006229-7yoilsho	5460	10	specified	specify	VBN
cord-006229-7yoilsho	5460	11	.	.	.
cord-006229-7yoilsho	5461	1	Health	health	NN
cord-006229-7yoilsho	5461	2	concerns	concern	NNS
cord-006229-7yoilsho	5461	3	about	about	IN
cord-006229-7yoilsho	5461	4	safety	safety	NN
cord-006229-7yoilsho	5461	5	of	of	IN
cord-006229-7yoilsho	5461	6	the	the	DT
cord-006229-7yoilsho	5461	7	HCA	HCA	NNP
cord-006229-7yoilsho	5461	8	-	-	HYPH
cord-006229-7yoilsho	5461	9	containing	contain	VBG
cord-006229-7yoilsho	5461	10	supplements	supplement	NNS
cord-006229-7yoilsho	5461	11	have	have	VBP
cord-006229-7yoilsho	5461	12	been	be	VBN
cord-006229-7yoilsho	5461	13	raised	raise	VBN
cord-006229-7yoilsho	5461	14	,	,	,
cord-006229-7yoilsho	5461	15	based	base	VBN
cord-006229-7yoilsho	5461	16	on	on	IN
cord-006229-7yoilsho	5461	17	results	result	NNS
cord-006229-7yoilsho	5461	18	from	from	IN
cord-006229-7yoilsho	5461	19	animal	animal	NN
cord-006229-7yoilsho	5461	20	studies	study	NNS
cord-006229-7yoilsho	5461	21	,	,	,
cord-006229-7yoilsho	5461	22	which	which	WDT
cord-006229-7yoilsho	5461	23	observed	observe	VBD
cord-006229-7yoilsho	5461	24	toxic	toxic	JJ
cord-006229-7yoilsho	5461	25	effects	effect	NNS
cord-006229-7yoilsho	5461	26	on	on	IN
cord-006229-7yoilsho	5461	27	the	the	DT
cord-006229-7yoilsho	5461	28	testis	testis	NN
cord-006229-7yoilsho	5461	29	and	and	CC
cord-006229-7yoilsho	5461	30	on	on	IN
cord-006229-7yoilsho	5461	31	spermatogenesis	spermatogenesis	NN
cord-006229-7yoilsho	5461	32	after	after	IN
cord-006229-7yoilsho	5461	33	administration	administration	NN
cord-006229-7yoilsho	5461	34	of	of	IN
cord-006229-7yoilsho	5461	35	preparations	preparation	NNS
cord-006229-7yoilsho	5461	36	containing	contain	VBG
cord-006229-7yoilsho	5461	37	high	high	JJ
cord-006229-7yoilsho	5461	38	HCA	HCA	NNP
cord-006229-7yoilsho	5461	39	doses	dose	NNS
cord-006229-7yoilsho	5461	40	.	.	.
cord-006229-7yoilsho	5462	1	In	in	IN
cord-006229-7yoilsho	5462	2	the	the	DT
cord-006229-7yoilsho	5462	3	current	current	JJ
cord-006229-7yoilsho	5462	4	risk	risk	NN
cord-006229-7yoilsho	5462	5	assessment	assessment	NN
cord-006229-7yoilsho	5462	6	,	,	,
cord-006229-7yoilsho	5462	7	the	the	DT
cord-006229-7yoilsho	5462	8	possible	possible	JJ
cord-006229-7yoilsho	5462	9	health	health	NN
cord-006229-7yoilsho	5462	10	risks	risk	NNS
cord-006229-7yoilsho	5462	11	associated	associate	VBN
cord-006229-7yoilsho	5462	12	with	with	IN
cord-006229-7yoilsho	5462	13	consumption	consumption	NN
cord-006229-7yoilsho	5462	14	of	of	IN
cord-006229-7yoilsho	5462	15	HCA	HCA	NNP
cord-006229-7yoilsho	5462	16	-	-	HYPH
cord-006229-7yoilsho	5462	17	containing	contain	VBG
cord-006229-7yoilsho	5462	18	dietary	dietary	JJ
cord-006229-7yoilsho	5462	19	supplements	supplement	NNS
cord-006229-7yoilsho	5462	20	(	(	-LRB-
cord-006229-7yoilsho	5462	21	HCA	HCA	NNP
cord-006229-7yoilsho	5462	22	doses	dose	NNS
cord-006229-7yoilsho	5462	23	of	of	IN
cord-006229-7yoilsho	5462	24	approximately	approximately	RB
cord-006229-7yoilsho	5462	25	1000	1000	CD
cord-006229-7yoilsho	5462	26	to	to	IN
cord-006229-7yoilsho	5462	27	3000	3000	CD
cord-006229-7yoilsho	5462	28	mg	mg	NN
cord-006229-7yoilsho	5462	29	per	per	IN
cord-006229-7yoilsho	5462	30	day	day	NN
cord-006229-7yoilsho	5462	31	)	)	-RRB-
cord-006229-7yoilsho	5462	32	were	be	VBD
cord-006229-7yoilsho	5462	33	evaluated	evaluate	VBN
cord-006229-7yoilsho	5462	34	based	base	VBN
cord-006229-7yoilsho	5462	35	on	on	IN
cord-006229-7yoilsho	5462	36	relevant	relevant	JJ
cord-006229-7yoilsho	5462	37	animal	animal	NN
cord-006229-7yoilsho	5462	38	and	and	CC
cord-006229-7yoilsho	5462	39	human	human	JJ
cord-006229-7yoilsho	5462	40	studies	study	NNS
cord-006229-7yoilsho	5462	41	with	with	IN
cord-006229-7yoilsho	5462	42	the	the	DT
cord-006229-7yoilsho	5462	43	focus	focus	NN
cord-006229-7yoilsho	5462	44	on	on	IN
cord-006229-7yoilsho	5462	45	testicular	testicular	JJ
cord-006229-7yoilsho	5462	46	toxicity	toxicity	NN
cord-006229-7yoilsho	5462	47	as	as	IN
cord-006229-7yoilsho	5462	48	a	a	DT
cord-006229-7yoilsho	5462	49	critical	critical	JJ
cord-006229-7yoilsho	5462	50	endpoint	endpoint	NN
cord-006229-7yoilsho	5462	51	.	.	.
cord-006229-7yoilsho	5463	1	In	in	IN
cord-006229-7yoilsho	5463	2	several	several	JJ
cord-006229-7yoilsho	5463	3	published	publish	VBN
cord-006229-7yoilsho	5463	4	animal	animal	NN
cord-006229-7yoilsho	5463	5	studies	study	NNS
cord-006229-7yoilsho	5463	6	,	,	,
cord-006229-7yoilsho	5463	7	repeated	repeat	VBN
cord-006229-7yoilsho	5463	8	(	(	-LRB-
cord-006229-7yoilsho	5463	9	short	short	JJ
cord-006229-7yoilsho	5463	10	-	-	HYPH
cord-006229-7yoilsho	5463	11	term	term	NN
cord-006229-7yoilsho	5463	12	or	or	CC
cord-006229-7yoilsho	5463	13	subchronic	subchronic	JJ
cord-006229-7yoilsho	5463	14	)	)	-RRB-
cord-006229-7yoilsho	5463	15	ingestion	ingestion	NN
cord-006229-7yoilsho	5463	16	of	of	IN
cord-006229-7yoilsho	5463	17	certain	certain	JJ
cord-006229-7yoilsho	5463	18	HCA	hca	NN
cord-006229-7yoilsho	5463	19	-	-	HYPH
cord-006229-7yoilsho	5463	20	preparations	preparation	NNS
cord-006229-7yoilsho	5463	21	(	(	-LRB-
cord-006229-7yoilsho	5463	22	G.	G.	NNP
cord-006229-7yoilsho	5463	23	cambogia	cambogia	NN
cord-006229-7yoilsho	5463	24	-	-	HYPH
cord-006229-7yoilsho	5463	25	extract	extract	NN
cord-006229-7yoilsho	5463	26	or	or	CC
cord-006229-7yoilsho	5464	1	Ca	ca	NN
cord-006229-7yoilsho	5464	2	2	2	CD
cord-006229-7yoilsho	5464	3	+	+	CD
cord-006229-7yoilsho	5464	4	-HCA	-HCA	HYPH
cord-006229-7yoilsho	5464	5	salt	salt	NN
cord-006229-7yoilsho	5464	6	)	)	-RRB-
cord-006229-7yoilsho	5464	7	induced	induce	VBN
cord-006229-7yoilsho	5464	8	testicular	testicular	JJ
cord-006229-7yoilsho	5464	9	atrophy	atrophy	NN
cord-006229-7yoilsho	5465	1	(	(	-LRB-
cord-006229-7yoilsho	5465	2	i.	i.	NNP
cord-006229-7yoilsho	5465	3	e.	e.	NNP
cord-006229-7yoilsho	5465	4	atrophy	atrophy	NNP
cord-006229-7yoilsho	5465	5	of	of	IN
cord-006229-7yoilsho	5465	6	seminiferous	seminiferous	JJ
cord-006229-7yoilsho	5465	7	tubules	tubule	NNS
cord-006229-7yoilsho	5465	8	,	,	,
cord-006229-7yoilsho	5465	9	degenerative	degenerative	JJ
cord-006229-7yoilsho	5465	10	changes	change	NNS
cord-006229-7yoilsho	5465	11	of	of	IN
cord-006229-7yoilsho	5465	12	Sertoli	sertoli	JJ
cord-006229-7yoilsho	5465	13	cells	cell	NNS
cord-006229-7yoilsho	5465	14	at	at	IN
cord-006229-7yoilsho	5465	15	histological	histological	JJ
cord-006229-7yoilsho	5465	16	examination	examination	NN
cord-006229-7yoilsho	5465	17	)	)	-RRB-
cord-006229-7yoilsho	5465	18	and	and	CC
cord-006229-7yoilsho	5465	19	impaired	impair	VBN
cord-006229-7yoilsho	5465	20	spermatogenesis	spermatogenesis	NN
cord-006229-7yoilsho	5466	1	(	(	-LRB-
cord-006229-7yoilsho	5466	2	i.	i.	NNP
cord-006229-7yoilsho	5466	3	e.	e.	NNP
cord-006229-7yoilsho	5466	4	decreased	decrease	VBD
cord-006229-7yoilsho	5466	5	sperm	sperm	NN
cord-006229-7yoilsho	5466	6	counts	count	NNS
cord-006229-7yoilsho	5466	7	)	)	-RRB-
cord-006229-7yoilsho	5466	8	in	in	IN
cord-006229-7yoilsho	5466	9	male	male	JJ
cord-006229-7yoilsho	5466	10	rats	rat	NNS
cord-006229-7yoilsho	5466	11	at	at	IN
cord-006229-7yoilsho	5466	12	high	high	JJ
cord-006229-7yoilsho	5466	13	doses	dose	NNS
cord-006229-7yoilsho	5466	14	(	(	-LRB-
cord-006229-7yoilsho	5466	15	NOAEL	NOAEL	NNS
cord-006229-7yoilsho	5466	16	and	and	CC
cord-006229-7yoilsho	5466	17	LOAEL	LOAEL	NNS
cord-006229-7yoilsho	5466	18	of	of	IN
cord-006229-7yoilsho	5466	19	389	389	CD
cord-006229-7yoilsho	5466	20	and	and	CC
cord-006229-7yoilsho	5466	21	778	778	CD
cord-006229-7yoilsho	5466	22	mg	mg	NNP
cord-006229-7yoilsho	5466	23	HCA	HCA	NNP
cord-006229-7yoilsho	5466	24	/	/	SYM
cord-006229-7yoilsho	5466	25	kg	kg	NNP
cord-006229-7yoilsho	5466	26	body	body	NN
cord-006229-7yoilsho	5466	27	weight	weight	NN
cord-006229-7yoilsho	5466	28	&	&	CC
cord-006229-7yoilsho	5466	29	day	day	NNP
cord-006229-7yoilsho	5466	30	,	,	,
cord-006229-7yoilsho	5466	31	respectively	respectively	RB
cord-006229-7yoilsho	5466	32	)	)	-RRB-
cord-006229-7yoilsho	5466	33	.	.	.
cord-006229-7yoilsho	5467	1	Animal	animal	NN
cord-006229-7yoilsho	5467	2	studies	study	NNS
cord-006229-7yoilsho	5467	3	with	with	IN
cord-006229-7yoilsho	5467	4	other	other	JJ
cord-006229-7yoilsho	5467	5	HCA	HCA	NNP
cord-006229-7yoilsho	5467	6	-	-	HYPH
cord-006229-7yoilsho	5467	7	preparations	preparation	NNS
cord-006229-7yoilsho	5468	1	(	(	-LRB-
cord-006229-7yoilsho	5468	2	Ca	ca	NN
cord-006229-7yoilsho	5468	3	2+/	2+/	CD
cord-006229-7yoilsho	5468	4	K	k	NN
cord-006229-7yoilsho	5468	5	+	+	CC
cord-006229-7yoilsho	5468	6	-HCA	-HCA	HYPH
cord-006229-7yoilsho	5468	7	salt	salt	NN
cord-006229-7yoilsho	5468	8	)	)	-RRB-
cord-006229-7yoilsho	5468	9	found	find	VBD
cord-006229-7yoilsho	5468	10	no	no	DT
cord-006229-7yoilsho	5468	11	such	such	JJ
cord-006229-7yoilsho	5468	12	effects	effect	NNS
cord-006229-7yoilsho	5468	13	at	at	IN
cord-006229-7yoilsho	5468	14	the	the	DT
cord-006229-7yoilsho	5468	15	highest	high	JJS
cord-006229-7yoilsho	5468	16	HCA	HCA	NNP
cord-006229-7yoilsho	5468	17	-	-	HYPH
cord-006229-7yoilsho	5468	18	doses	dose	NNS
cord-006229-7yoilsho	5468	19	tested	test	VBD
cord-006229-7yoilsho	5468	20	(	(	-LRB-
cord-006229-7yoilsho	5468	21	NOAEL	NOAEL	NNS
cord-006229-7yoilsho	5468	22	:	:	:
cord-006229-7yoilsho	5469	1	610,8	610,8	CD
cord-006229-7yoilsho	5469	2	mg	mg	NNP
cord-006229-7yoilsho	5469	3	HCA	HCA	NNP
cord-006229-7yoilsho	5469	4	/	/	SYM
cord-006229-7yoilsho	5469	5	kg	kg	NNP
cord-006229-7yoilsho	5469	6	bwt	bwt	NNP
cord-006229-7yoilsho	5469	7	&	&	CC
cord-006229-7yoilsho	5469	8	day	day	NNP
cord-006229-7yoilsho	5469	9	)	)	-RRB-
cord-006229-7yoilsho	5469	10	.	.	.
cord-006229-7yoilsho	5470	1	Human	human	JJ
cord-006229-7yoilsho	5470	2	intervention	intervention	NN
cord-006229-7yoilsho	5470	3	studies	study	NNS
cord-006229-7yoilsho	5470	4	which	which	WDT
cord-006229-7yoilsho	5470	5	addressed	address	VBD
cord-006229-7yoilsho	5470	6	the	the	DT
cord-006229-7yoilsho	5470	7	safety	safety	NN
cord-006229-7yoilsho	5470	8	of	of	IN
cord-006229-7yoilsho	5470	9	HCA	HCA	NNP
cord-006229-7yoilsho	5470	10	in	in	IN
cord-006229-7yoilsho	5470	11	healthy	healthy	JJ
cord-006229-7yoilsho	5470	12	test	test	NN
cord-006229-7yoilsho	5470	13	persons	person	NNS
cord-006229-7yoilsho	5470	14	reported	report	VBD
cord-006229-7yoilsho	5470	15	no	no	DT
cord-006229-7yoilsho	5470	16	substancespecific	substancespecific	JJ
cord-006229-7yoilsho	5470	17	adverse	adverse	JJ
cord-006229-7yoilsho	5470	18	effects	effect	NNS
cord-006229-7yoilsho	5470	19	after	after	IN
cord-006229-7yoilsho	5470	20	ingestion	ingestion	NN
cord-006229-7yoilsho	5470	21	of	of	IN
cord-006229-7yoilsho	5470	22	HCA	HCA	NNP
cord-006229-7yoilsho	5470	23	doses	dose	NNS
cord-006229-7yoilsho	5470	24	up	up	IN
cord-006229-7yoilsho	5470	25	to	to	TO
cord-006229-7yoilsho	5470	26	3000	3000	CD
cord-006229-7yoilsho	5470	27	mg	mg	NN
cord-006229-7yoilsho	5470	28	per	per	IN
cord-006229-7yoilsho	5470	29	day	day	NN
cord-006229-7yoilsho	5470	30	over	over	IN
cord-006229-7yoilsho	5470	31	the	the	DT
cord-006229-7yoilsho	5470	32	period	period	NN
cord-006229-7yoilsho	5470	33	of	of	IN
cord-006229-7yoilsho	5470	34	up	up	IN
cord-006229-7yoilsho	5470	35	to	to	TO
cord-006229-7yoilsho	5470	36	12	12	CD
cord-006229-7yoilsho	5470	37	weeks	week	NNS
cord-006229-7yoilsho	5470	38	.	.	.
cord-006229-7yoilsho	5471	1	However	however	RB
cord-006229-7yoilsho	5471	2	,	,	,
cord-006229-7yoilsho	5471	3	the	the	DT
cord-006229-7yoilsho	5471	4	question	question	NN
cord-006229-7yoilsho	5471	5	of	of	IN
cord-006229-7yoilsho	5471	6	possible	possible	JJ
cord-006229-7yoilsho	5471	7	adverse	adverse	JJ
cord-006229-7yoilsho	5471	8	effects	effect	NNS
cord-006229-7yoilsho	5471	9	of	of	IN
cord-006229-7yoilsho	5471	10	HCA	HCA	NNP
cord-006229-7yoilsho	5471	11	on	on	IN
cord-006229-7yoilsho	5471	12	the	the	DT
cord-006229-7yoilsho	5471	13	human	human	JJ
cord-006229-7yoilsho	5471	14	testes	testis	NNS
cord-006229-7yoilsho	5471	15	was	be	VBD
cord-006229-7yoilsho	5471	16	not	not	RB
cord-006229-7yoilsho	5471	17	adequately	adequately	RB
cord-006229-7yoilsho	5471	18	addressed	address	VBN
cord-006229-7yoilsho	5471	19	in	in	IN
cord-006229-7yoilsho	5471	20	studies	study	NNS
cord-006229-7yoilsho	5471	21	with	with	IN
cord-006229-7yoilsho	5471	22	human	human	JJ
cord-006229-7yoilsho	5471	23	volunteers	volunteer	NNS
cord-006229-7yoilsho	5471	24	.	.	.
cord-006229-7yoilsho	5472	1	In	in	IN
cord-006229-7yoilsho	5472	2	a	a	DT
cord-006229-7yoilsho	5472	3	single	single	JJ
cord-006229-7yoilsho	5472	4	clinical	clinical	JJ
cord-006229-7yoilsho	5472	5	study	study	NN
cord-006229-7yoilsho	5472	6	with	with	IN
cord-006229-7yoilsho	5472	7	24	24	CD
cord-006229-7yoilsho	5472	8	male	male	JJ
cord-006229-7yoilsho	5472	9	test	test	NN
cord-006229-7yoilsho	5472	10	subjects	subject	NNS
cord-006229-7yoilsho	5472	11	,	,	,
cord-006229-7yoilsho	5472	12	no	no	DT
cord-006229-7yoilsho	5472	13	significant	significant	JJ
cord-006229-7yoilsho	5472	14	changes	change	NNS
cord-006229-7yoilsho	5472	15	in	in	IN
cord-006229-7yoilsho	5472	16	endocrinologically	endocrinologically	RB
cord-006229-7yoilsho	5472	17	relevant	relevant	JJ
cord-006229-7yoilsho	5472	18	parameters	parameter	NNS
cord-006229-7yoilsho	5472	19	such	such	JJ
cord-006229-7yoilsho	5472	20	as	as	IN
cord-006229-7yoilsho	5472	21	serum	serum	NN
cord-006229-7yoilsho	5472	22	inhibin	inhibin	NNP
cord-006229-7yoilsho	5472	23	B	B	NNP
cord-006229-7yoilsho	5472	24	or	or	CC
cord-006229-7yoilsho	5472	25	FSH	FSH	NNP
cord-006229-7yoilsho	5472	26	were	be	VBD
cord-006229-7yoilsho	5472	27	observed	observe	VBN
cord-006229-7yoilsho	5472	28	after	after	IN
cord-006229-7yoilsho	5472	29	consumption	consumption	NN
cord-006229-7yoilsho	5472	30	of	of	IN
cord-006229-7yoilsho	5472	31	3000	3000	CD
cord-006229-7yoilsho	5472	32	mg	mg	NN
cord-006229-7yoilsho	5472	33	of	of	IN
cord-006229-7yoilsho	5472	34	HCA	HCA	NNP
cord-006229-7yoilsho	5472	35	for	for	IN
cord-006229-7yoilsho	5472	36	12	12	CD
cord-006229-7yoilsho	5472	37	weeks	week	NNS
cord-006229-7yoilsho	5472	38	.	.	.
cord-006229-7yoilsho	5473	1	However	however	RB
cord-006229-7yoilsho	5473	2	,	,	,
cord-006229-7yoilsho	5473	3	no	no	DT
cord-006229-7yoilsho	5473	4	investigations	investigation	NNS
cord-006229-7yoilsho	5473	5	of	of	IN
cord-006229-7yoilsho	5473	6	direct	direct	JJ
cord-006229-7yoilsho	5473	7	parameters	parameter	NNS
cord-006229-7yoilsho	5473	8	that	that	WDT
cord-006229-7yoilsho	5473	9	might	may	MD
cord-006229-7yoilsho	5473	10	inform	inform	VB
cord-006229-7yoilsho	5473	11	on	on	IN
cord-006229-7yoilsho	5473	12	potential	potential	JJ
cord-006229-7yoilsho	5473	13	effects	effect	NNS
cord-006229-7yoilsho	5473	14	on	on	IN
cord-006229-7yoilsho	5473	15	spermatogenesis	spermatogenesis	NN
cord-006229-7yoilsho	5473	16	,	,	,
cord-006229-7yoilsho	5473	17	such	such	JJ
cord-006229-7yoilsho	5473	18	as	as	IN
cord-006229-7yoilsho	5473	19	sperm	sperm	NN
cord-006229-7yoilsho	5473	20	quality	quality	NN
cord-006229-7yoilsho	5473	21	and	and	CC
cord-006229-7yoilsho	5473	22	sperm	sperm	NN
cord-006229-7yoilsho	5473	23	count	count	NN
cord-006229-7yoilsho	5473	24	,	,	,
cord-006229-7yoilsho	5473	25	were	be	VBD
cord-006229-7yoilsho	5473	26	conducted	conduct	VBN
cord-006229-7yoilsho	5473	27	in	in	IN
cord-006229-7yoilsho	5473	28	this	this	DT
cord-006229-7yoilsho	5473	29	study	study	NN
cord-006229-7yoilsho	5473	30	.	.	.
cord-006229-7yoilsho	5474	1	Considering	consider	VBG
cord-006229-7yoilsho	5474	2	the	the	DT
cord-006229-7yoilsho	5474	3	serious	serious	JJ
cord-006229-7yoilsho	5474	4	adverse	adverse	JJ
cord-006229-7yoilsho	5474	5	effects	effect	NNS
cord-006229-7yoilsho	5474	6	on	on	IN
cord-006229-7yoilsho	5474	7	the	the	DT
cord-006229-7yoilsho	5474	8	testes	testis	NNS
cord-006229-7yoilsho	5474	9	observed	observe	VBN
cord-006229-7yoilsho	5474	10	in	in	IN
cord-006229-7yoilsho	5474	11	several	several	JJ
cord-006229-7yoilsho	5474	12	animal	animal	NN
cord-006229-7yoilsho	5474	13	studies	study	NNS
cord-006229-7yoilsho	5474	14	as	as	RB
cord-006229-7yoilsho	5474	15	well	well	RB
cord-006229-7yoilsho	5474	16	as	as	IN
cord-006229-7yoilsho	5474	17	in	in	IN
cord-006229-7yoilsho	5474	18	view	view	NN
cord-006229-7yoilsho	5474	19	of	of	IN
cord-006229-7yoilsho	5474	20	lack	lack	NN
cord-006229-7yoilsho	5474	21	of	of	IN
cord-006229-7yoilsho	5474	22	the	the	DT
cord-006229-7yoilsho	5474	23	adequate	adequate	JJ
cord-006229-7yoilsho	5474	24	human	human	JJ
cord-006229-7yoilsho	5474	25	data	datum	NNS
cord-006229-7yoilsho	5474	26	on	on	IN
cord-006229-7yoilsho	5474	27	the	the	DT
cord-006229-7yoilsho	5474	28	safety	safety	NN
cord-006229-7yoilsho	5474	29	of	of	IN
cord-006229-7yoilsho	5474	30	the	the	DT
cord-006229-7yoilsho	5474	31	long	long	JJ
cord-006229-7yoilsho	5474	32	-	-	HYPH
cord-006229-7yoilsho	5474	33	term	term	NN
cord-006229-7yoilsho	5474	34	use	use	NN
cord-006229-7yoilsho	5474	35	of	of	IN
cord-006229-7yoilsho	5474	36	HCA	hca	NN
cord-006229-7yoilsho	5474	37	-	-	HYPH
cord-006229-7yoilsho	5474	38	preparations	preparation	NNS
cord-006229-7yoilsho	5474	39	,	,	,
cord-006229-7yoilsho	5474	40	it	-PRON-	PRP
cord-006229-7yoilsho	5474	41	is	be	VBZ
cord-006229-7yoilsho	5474	42	concluded	conclude	VBN
cord-006229-7yoilsho	5474	43	that	that	IN
cord-006229-7yoilsho	5474	44	knowledge	knowledge	NN
cord-006229-7yoilsho	5474	45	gaps	gap	NNS
cord-006229-7yoilsho	5474	46	and	and	CC
cord-006229-7yoilsho	5474	47	substantial	substantial	JJ
cord-006229-7yoilsho	5474	48	uncertainties	uncertainty	NNS
cord-006229-7yoilsho	5474	49	exist	exist	VBP
cord-006229-7yoilsho	5474	50	regarding	regard	VBG
cord-006229-7yoilsho	5474	51	the	the	DT
cord-006229-7yoilsho	5474	52	safety	safety	NN
cord-006229-7yoilsho	5474	53	with	with	IN
cord-006229-7yoilsho	5474	54	respect	respect	NN
cord-006229-7yoilsho	5474	55	to	to	IN
cord-006229-7yoilsho	5474	56	human	human	JJ
cord-006229-7yoilsho	5474	57	health	health	NN
cord-006229-7yoilsho	5474	58	of	of	IN
cord-006229-7yoilsho	5474	59	high	high	JJ
cord-006229-7yoilsho	5474	60	amounts	amount	NNS
cord-006229-7yoilsho	5474	61	of	of	IN
cord-006229-7yoilsho	5474	62	HCA	HCA	NNP
cord-006229-7yoilsho	5474	63	found	find	VBN
cord-006229-7yoilsho	5474	64	in	in	IN
cord-006229-7yoilsho	5474	65	commercially	commercially	RB
cord-006229-7yoilsho	5474	66	available	available	JJ
cord-006229-7yoilsho	5474	67	food	food	NN
cord-006229-7yoilsho	5474	68	supplements	supplement	NNS
cord-006229-7yoilsho	5474	69	,	,	,
cord-006229-7yoilsho	5474	70	particularly	particularly	RB
cord-006229-7yoilsho	5474	71	with	with	IN
cord-006229-7yoilsho	5474	72	regard	regard	NN
cord-006229-7yoilsho	5474	73	to	to	IN
cord-006229-7yoilsho	5474	74	the	the	DT
cord-006229-7yoilsho	5474	75	human	human	JJ
cord-006229-7yoilsho	5474	76	male	male	JJ
cord-006229-7yoilsho	5474	77	reproductive	reproductive	JJ
cord-006229-7yoilsho	5474	78	system	system	NN
cord-006229-7yoilsho	5474	79	.	.	.
cord-006229-7yoilsho	5475	1	A	a	DT
cord-006229-7yoilsho	5475	2	critical	critical	JJ
cord-006229-7yoilsho	5475	3	look	look	NN
cord-006229-7yoilsho	5475	4	on	on	IN
cord-006229-7yoilsho	5475	5	the	the	DT
cord-006229-7yoilsho	5475	6	Passing	passing	JJ
cord-006229-7yoilsho	5475	7	-	-	HYPH
cord-006229-7yoilsho	5475	8	Bablok	bablok	NN
cord-006229-7yoilsho	5475	9	-	-	HYPH
cord-006229-7yoilsho	5475	10	regression	regression	NN
cord-006229-7yoilsho	5475	11	B.	B.	NNP
cord-006229-7yoilsho	5475	12	Mayer	Mayer	NNP
cord-006229-7yoilsho	5475	13	1	1	CD
cord-006229-7yoilsho	5475	14	1	1	CD
cord-006229-7yoilsho	5475	15	Universität	Universität	NNP
cord-006229-7yoilsho	5475	16	Ulm	Ulm	NNP
cord-006229-7yoilsho	5475	17	,	,	,
cord-006229-7yoilsho	5475	18	Institut	Institut	NNP
cord-006229-7yoilsho	5475	19	für	für	IN
cord-006229-7yoilsho	5475	20	Epidemiologie	Epidemiologie	NNP
cord-006229-7yoilsho	5476	1	und	und	IN
cord-006229-7yoilsho	5476	2	Medizinische	Medizinische	NNP
cord-006229-7yoilsho	5476	3	Biometrie	Biometrie	NNP
cord-006229-7yoilsho	5476	4	,	,	,
cord-006229-7yoilsho	5476	5	Ulm	Ulm	NNP
cord-006229-7yoilsho	5476	6	,	,	,
cord-006229-7yoilsho	5477	1	Germany	Germany	NNP
cord-006229-7yoilsho	5477	2	Background	Background	NNP
cord-006229-7yoilsho	5477	3	:	:	:
cord-006229-7yoilsho	5478	1	The	the	DT
cord-006229-7yoilsho	5478	2	Passing	passing	JJ
cord-006229-7yoilsho	5478	3	-	-	HYPH
cord-006229-7yoilsho	5478	4	Bablok	bablok	NN
cord-006229-7yoilsho	5478	5	(	(	-LRB-
cord-006229-7yoilsho	5478	6	PB)-regression	pb)-regression	CD
cord-006229-7yoilsho	5478	7	is	be	VBZ
cord-006229-7yoilsho	5478	8	a	a	DT
cord-006229-7yoilsho	5478	9	commonly	commonly	RB
cord-006229-7yoilsho	5478	10	used	use	VBN
cord-006229-7yoilsho	5478	11	approach	approach	NN
cord-006229-7yoilsho	5478	12	to	to	TO
cord-006229-7yoilsho	5478	13	prove	prove	VB
cord-006229-7yoilsho	5478	14	the	the	DT
cord-006229-7yoilsho	5478	15	equality	equality	NN
cord-006229-7yoilsho	5478	16	of	of	IN
cord-006229-7yoilsho	5478	17	different	different	JJ
cord-006229-7yoilsho	5478	18	analytical	analytical	JJ
cord-006229-7yoilsho	5478	19	methods	method	NNS
cord-006229-7yoilsho	5478	20	when	when	WRB
cord-006229-7yoilsho	5478	21	studying	study	VBG
cord-006229-7yoilsho	5478	22	quantitative	quantitative	JJ
cord-006229-7yoilsho	5478	23	laboratory	laboratory	NN
cord-006229-7yoilsho	5478	24	data	datum	NNS
cord-006229-7yoilsho	5478	25	.	.	.
cord-006229-7yoilsho	5479	1	It	-PRON-	PRP
cord-006229-7yoilsho	5479	2	is	be	VBZ
cord-006229-7yoilsho	5479	3	based	base	VBN
cord-006229-7yoilsho	5479	4	on	on	IN
cord-006229-7yoilsho	5479	5	the	the	DT
cord-006229-7yoilsho	5479	6	assumption	assumption	NN
cord-006229-7yoilsho	5479	7	that	that	IN
cord-006229-7yoilsho	5479	8	the	the	DT
cord-006229-7yoilsho	5479	9	measurements	measurement	NNS
cord-006229-7yoilsho	5479	10	of	of	IN
cord-006229-7yoilsho	5479	11	two	two	CD
cord-006229-7yoilsho	5479	12	methods	method	NNS
cord-006229-7yoilsho	5479	13	are	be	VBP
cord-006229-7yoilsho	5479	14	linearly	linearly	RB
cord-006229-7yoilsho	5479	15	related	relate	VBN
cord-006229-7yoilsho	5479	16	.	.	.
cord-006229-7yoilsho	5480	1	If	if	IN
cord-006229-7yoilsho	5480	2	then	then	RB
cord-006229-7yoilsho	5480	3	one	one	CD
cord-006229-7yoilsho	5480	4	method	method	NN
cord-006229-7yoilsho	5480	5	is	be	VBZ
cord-006229-7yoilsho	5480	6	regressed	regress	VBN
cord-006229-7yoilsho	5480	7	onto	onto	IN
cord-006229-7yoilsho	5480	8	the	the	DT
cord-006229-7yoilsho	5480	9	other	other	JJ
cord-006229-7yoilsho	5480	10	and	and	CC
cord-006229-7yoilsho	5480	11	the	the	DT
cord-006229-7yoilsho	5480	12	respective	respective	JJ
cord-006229-7yoilsho	5480	13	confidence	confidence	NN
cord-006229-7yoilsho	5480	14	intervals	interval	NNS
cord-006229-7yoilsho	5480	15	of	of	IN
cord-006229-7yoilsho	5480	16	the	the	DT
cord-006229-7yoilsho	5480	17	intercept	intercept	NN
cord-006229-7yoilsho	5480	18	and	and	CC
cord-006229-7yoilsho	5480	19	the	the	DT
cord-006229-7yoilsho	5480	20	slope	slope	NN
cord-006229-7yoilsho	5480	21	include	include	VBP
cord-006229-7yoilsho	5480	22	0	0	CD
cord-006229-7yoilsho	5480	23	and	and	CC
cord-006229-7yoilsho	5480	24	1	1	CD
cord-006229-7yoilsho	5480	25	,	,	,
cord-006229-7yoilsho	5480	26	respectively	respectively	RB
cord-006229-7yoilsho	5480	27	,	,	,
cord-006229-7yoilsho	5480	28	it	-PRON-	PRP
cord-006229-7yoilsho	5480	29	is	be	VBZ
cord-006229-7yoilsho	5480	30	assumed	assume	VBN
cord-006229-7yoilsho	5480	31	to	to	TO
cord-006229-7yoilsho	5480	32	have	have	VB
cord-006229-7yoilsho	5480	33	a	a	DT
cord-006229-7yoilsho	5480	34	proof	proof	NN
cord-006229-7yoilsho	5480	35	of	of	IN
cord-006229-7yoilsho	5480	36	methods	method	NNS
cord-006229-7yoilsho	5480	37	equality	equality	NN
cord-006229-7yoilsho	5480	38	.	.	.
cord-006229-7yoilsho	5481	1	However	however	RB
cord-006229-7yoilsho	5481	2	,	,	,
cord-006229-7yoilsho	5481	3	this	this	DT
cord-006229-7yoilsho	5481	4	conclusion	conclusion	NN
cord-006229-7yoilsho	5481	5	is	be	VBZ
cord-006229-7yoilsho	5481	6	problematic	problematic	JJ
cord-006229-7yoilsho	5481	7	in	in	IN
cord-006229-7yoilsho	5481	8	respect	respect	NN
cord-006229-7yoilsho	5481	9	of	of	IN
cord-006229-7yoilsho	5481	10	an	an	DT
cord-006229-7yoilsho	5481	11	essential	essential	JJ
cord-006229-7yoilsho	5481	12	principle	principle	NN
cord-006229-7yoilsho	5481	13	of	of	IN
cord-006229-7yoilsho	5481	14	statistical	statistical	JJ
cord-006229-7yoilsho	5481	15	hypothesis	hypothesis	NN
cord-006229-7yoilsho	5481	16	testing	testing	NN
cord-006229-7yoilsho	5481	17	.	.	.
cord-006229-7yoilsho	5482	1	Methods	method	NNS
cord-006229-7yoilsho	5482	2	:	:	:
cord-006229-7yoilsho	5482	3	In	in	IN
cord-006229-7yoilsho	5482	4	this	this	DT
cord-006229-7yoilsho	5482	5	talk	talk	NN
cord-006229-7yoilsho	5482	6	the	the	DT
cord-006229-7yoilsho	5482	7	general	general	JJ
cord-006229-7yoilsho	5482	8	idea	idea	NN
cord-006229-7yoilsho	5482	9	behind	behind	IN
cord-006229-7yoilsho	5482	10	the	the	DT
cord-006229-7yoilsho	5482	11	PB	pb	NN
cord-006229-7yoilsho	5482	12	-	-	HYPH
cord-006229-7yoilsho	5482	13	regression	regression	NN
cord-006229-7yoilsho	5482	14	is	be	VBZ
cord-006229-7yoilsho	5482	15	discussed	discuss	VBN
cord-006229-7yoilsho	5482	16	critically	critically	RB
cord-006229-7yoilsho	5482	17	.	.	.
cord-006229-7yoilsho	5483	1	Although	although	IN
cord-006229-7yoilsho	5483	2	the	the	DT
cord-006229-7yoilsho	5483	3	method	method	NN
cord-006229-7yoilsho	5483	4	makes	make	VBZ
cord-006229-7yoilsho	5483	5	use	use	NN
cord-006229-7yoilsho	5483	6	of	of	IN
cord-006229-7yoilsho	5483	7	confidence	confidence	NN
cord-006229-7yoilsho	5483	8	intervals	interval	NNS
cord-006229-7yoilsho	5483	9	a	a	DT
cord-006229-7yoilsho	5483	10	decision	decision	NN
cord-006229-7yoilsho	5483	11	is	be	VBZ
cord-006229-7yoilsho	5483	12	made	make	VBN
cord-006229-7yoilsho	5483	13	,	,	,
cord-006229-7yoilsho	5483	14	which	which	WDT
cord-006229-7yoilsho	5483	15	is	be	VBZ
cord-006229-7yoilsho	5483	16	why	why	WRB
cord-006229-7yoilsho	5483	17	it	-PRON-	PRP
cord-006229-7yoilsho	5483	18	is	be	VBZ
cord-006229-7yoilsho	5483	19	important	important	JJ
cord-006229-7yoilsho	5483	20	to	to	TO
cord-006229-7yoilsho	5483	21	discuss	discuss	VB
cord-006229-7yoilsho	5483	22	how	how	WRB
cord-006229-7yoilsho	5483	23	the	the	DT
cord-006229-7yoilsho	5483	24	results	result	NNS
cord-006229-7yoilsho	5483	25	of	of	IN
cord-006229-7yoilsho	5483	26	a	a	DT
cord-006229-7yoilsho	5483	27	statistical	statistical	JJ
cord-006229-7yoilsho	5483	28	hypothesis	hypothesis	NN
cord-006229-7yoilsho	5483	29	test	test	NN
cord-006229-7yoilsho	5483	30	have	have	VBP
cord-006229-7yoilsho	5483	31	to	to	TO
cord-006229-7yoilsho	5483	32	be	be	VB
cord-006229-7yoilsho	5483	33	interpreted	interpret	VBN
cord-006229-7yoilsho	5483	34	.	.	.
cord-006229-7yoilsho	5484	1	Moreover	moreover	RB
cord-006229-7yoilsho	5484	2	,	,	,
cord-006229-7yoilsho	5484	3	alternative	alternative	JJ
cord-006229-7yoilsho	5484	4	statistical	statistical	JJ
cord-006229-7yoilsho	5484	5	approaches	approach	NNS
cord-006229-7yoilsho	5484	6	to	to	TO
cord-006229-7yoilsho	5484	7	investigate	investigate	VB
cord-006229-7yoilsho	5484	8	agreement	agreement	NN
cord-006229-7yoilsho	5484	9	in	in	IN
cord-006229-7yoilsho	5484	10	biometrical	biometrical	JJ
cord-006229-7yoilsho	5484	11	practice	practice	NN
cord-006229-7yoilsho	5484	12	are	be	VBP
cord-006229-7yoilsho	5484	13	pointed	point	VBN
cord-006229-7yoilsho	5484	14	out	out	RP
cord-006229-7yoilsho	5484	15	by	by	IN
cord-006229-7yoilsho	5484	16	means	mean	NNS
cord-006229-7yoilsho	5484	17	of	of	IN
cord-006229-7yoilsho	5484	18	a	a	DT
cord-006229-7yoilsho	5484	19	practical	practical	JJ
cord-006229-7yoilsho	5484	20	example	example	NN
cord-006229-7yoilsho	5484	21	and	and	CC
cord-006229-7yoilsho	5484	22	their	-PRON-	PRP$
cord-006229-7yoilsho	5484	23	advantages	advantage	NNS
cord-006229-7yoilsho	5484	24	and	and	CC
cord-006229-7yoilsho	5484	25	limitations	limitation	NNS
cord-006229-7yoilsho	5484	26	are	be	VBP
cord-006229-7yoilsho	5484	27	addressed	address	VBN
cord-006229-7yoilsho	5484	28	.	.	.
cord-006229-7yoilsho	5485	1	Results	result	NNS
cord-006229-7yoilsho	5485	2	:	:	:
cord-006229-7yoilsho	5486	1	All	all	DT
cord-006229-7yoilsho	5486	2	approaches	approach	NNS
cord-006229-7yoilsho	5486	3	applied	apply	VBD
cord-006229-7yoilsho	5486	4	to	to	IN
cord-006229-7yoilsho	5486	5	a	a	DT
cord-006229-7yoilsho	5486	6	sample	sample	NN
cord-006229-7yoilsho	5486	7	data	datum	NNS
cord-006229-7yoilsho	5486	8	set	set	VBN
cord-006229-7yoilsho	5486	9	led	lead	VBD
cord-006229-7yoilsho	5486	10	to	to	IN
cord-006229-7yoilsho	5486	11	the	the	DT
cord-006229-7yoilsho	5486	12	same	same	JJ
cord-006229-7yoilsho	5486	13	conclusions	conclusion	NNS
cord-006229-7yoilsho	5486	14	.	.	.
cord-006229-7yoilsho	5487	1	Demonstrating	demonstrate	VBG
cord-006229-7yoilsho	5487	2	methods	method	NNS
cord-006229-7yoilsho	5487	3	equality	equality	NN
cord-006229-7yoilsho	5487	4	though	though	RB
cord-006229-7yoilsho	5487	5	necessitates	necessitate	VBZ
cord-006229-7yoilsho	5487	6	an	an	DT
cord-006229-7yoilsho	5487	7	a	a	DT
cord-006229-7yoilsho	5487	8	-	-	HYPH
cord-006229-7yoilsho	5487	9	priori	priori	FW
cord-006229-7yoilsho	5487	10	definition	definition	NN
cord-006229-7yoilsho	5487	11	of	of	IN
cord-006229-7yoilsho	5487	12	an	an	DT
cord-006229-7yoilsho	5487	13	appropriate	appropriate	JJ
cord-006229-7yoilsho	5487	14	equivalence	equivalence	NN
cord-006229-7yoilsho	5487	15	margin	margin	NN
cord-006229-7yoilsho	5487	16	.	.	.
cord-006229-7yoilsho	5488	1	Conclusion	conclusion	NN
cord-006229-7yoilsho	5488	2	:	:	:
cord-006229-7yoilsho	5489	1	The	the	DT
cord-006229-7yoilsho	5489	2	PB	pb	NN
cord-006229-7yoilsho	5489	3	-	-	HYPH
cord-006229-7yoilsho	5489	4	regression	regression	NN
cord-006229-7yoilsho	5489	5	may	may	MD
cord-006229-7yoilsho	5489	6	give	give	VB
cord-006229-7yoilsho	5489	7	useful	useful	JJ
cord-006229-7yoilsho	5489	8	advice	advice	NN
cord-006229-7yoilsho	5489	9	when	when	WRB
cord-006229-7yoilsho	5489	10	comparing	compare	VBG
cord-006229-7yoilsho	5489	11	two	two	CD
cord-006229-7yoilsho	5489	12	measurement	measurement	NN
cord-006229-7yoilsho	5489	13	methods	method	NNS
cord-006229-7yoilsho	5489	14	towards	towards	IN
cord-006229-7yoilsho	5489	15	equality	equality	NN
cord-006229-7yoilsho	5489	16	.	.	.
cord-006229-7yoilsho	5490	1	However	however	RB
cord-006229-7yoilsho	5490	2	,	,	,
cord-006229-7yoilsho	5490	3	its	-PRON-	PRP$
cord-006229-7yoilsho	5490	4	results	result	NNS
cord-006229-7yoilsho	5490	5	are	be	VBP
cord-006229-7yoilsho	5490	6	statistically	statistically	RB
cord-006229-7yoilsho	5490	7	inconclusive	inconclusive	JJ
cord-006229-7yoilsho	5490	8	,	,	,
cord-006229-7yoilsho	5490	9	since	since	IN
cord-006229-7yoilsho	5490	10	the	the	DT
cord-006229-7yoilsho	5490	11	PB	pb	NN
cord-006229-7yoilsho	5490	12	-	-	HYPH
cord-006229-7yoilsho	5490	13	method	method	NN
cord-006229-7yoilsho	5490	14	does	do	VBZ
cord-006229-7yoilsho	5490	15	not	not	RB
cord-006229-7yoilsho	5490	16	follow	follow	VB
cord-006229-7yoilsho	5490	17	the	the	DT
cord-006229-7yoilsho	5490	18	principle	principle	NN
cord-006229-7yoilsho	5490	19	of	of	IN
cord-006229-7yoilsho	5490	20	equivalence	equivalence	NN
cord-006229-7yoilsho	5490	21	testing	testing	NN
cord-006229-7yoilsho	5490	22	.	.	.
cord-006229-7yoilsho	5491	1	Alternative	alternative	JJ
cord-006229-7yoilsho	5491	2	measures	measure	NNS
cord-006229-7yoilsho	5491	3	of	of	IN
cord-006229-7yoilsho	5491	4	agreement	agreement	NN
cord-006229-7yoilsho	5491	5	should	should	MD
cord-006229-7yoilsho	5491	6	be	be	VB
cord-006229-7yoilsho	5491	7	applied	apply	VBN
cord-006229-7yoilsho	5491	8	instead	instead	RB
cord-006229-7yoilsho	5491	9	to	to	TO
cord-006229-7yoilsho	5491	10	ensure	ensure	VB
cord-006229-7yoilsho	5491	11	results	result	NNS
cord-006229-7yoilsho	5491	12	which	which	WDT
cord-006229-7yoilsho	5491	13	are	be	VBP
cord-006229-7yoilsho	5491	14	not	not	RB
cord-006229-7yoilsho	5491	15	attackable	attackable	JJ
cord-006229-7yoilsho	5491	16	and	and	CC
cord-006229-7yoilsho	5491	17	serve	serve	VBP
cord-006229-7yoilsho	5491	18	as	as	IN
cord-006229-7yoilsho	5491	19	a	a	DT
cord-006229-7yoilsho	5491	20	statistical	statistical	JJ
cord-006229-7yoilsho	5491	21	proof	proof	NN
cord-006229-7yoilsho	5491	22	.	.	.
cord-006229-7yoilsho	5492	1	Insulin	insulin	NN
cord-006229-7yoilsho	5492	2	is	be	VBZ
cord-006229-7yoilsho	5492	3	an	an	DT
cord-006229-7yoilsho	5492	4	important	important	JJ
cord-006229-7yoilsho	5492	5	parameter	parameter	NN
cord-006229-7yoilsho	5492	6	both	both	CC
cord-006229-7yoilsho	5492	7	in	in	IN
cord-006229-7yoilsho	5492	8	toxicology	toxicology	NN
cord-006229-7yoilsho	5492	9	(	(	-LRB-
cord-006229-7yoilsho	5492	10	toxicity	toxicity	NN
cord-006229-7yoilsho	5492	11	to	to	IN
cord-006229-7yoilsho	5492	12	the	the	DT
cord-006229-7yoilsho	5492	13	endocrine	endocrine	JJ
cord-006229-7yoilsho	5492	14	pancreas	pancrea	NNS
cord-006229-7yoilsho	5492	15	)	)	-RRB-
cord-006229-7yoilsho	5492	16	and	and	CC
cord-006229-7yoilsho	5492	17	pharmacology	pharmacology	NN
cord-006229-7yoilsho	5492	18	(	(	-LRB-
cord-006229-7yoilsho	5492	19	models	model	NNS
cord-006229-7yoilsho	5492	20	of	of	IN
cord-006229-7yoilsho	5492	21	diabetes	diabetes	NN
cord-006229-7yoilsho	5492	22	and	and	CC
cord-006229-7yoilsho	5492	23	metabolic	metabolic	JJ
cord-006229-7yoilsho	5492	24	syndrome	syndrome	NN
cord-006229-7yoilsho	5492	25	)	)	-RRB-
cord-006229-7yoilsho	5492	26	.	.	.
cord-006229-7yoilsho	5493	1	Currently	currently	RB
cord-006229-7yoilsho	5493	2	available	available	JJ
cord-006229-7yoilsho	5493	3	ELISA	ELISA	NNP
cord-006229-7yoilsho	5493	4	and	and	CC
cord-006229-7yoilsho	5493	5	RIA	RIA	NNP
cord-006229-7yoilsho	5493	6	methodologies	methodology	NNS
cord-006229-7yoilsho	5493	7	for	for	IN
cord-006229-7yoilsho	5493	8	insulin	insulin	NN
cord-006229-7yoilsho	5493	9	often	often	RB
cord-006229-7yoilsho	5493	10	require	require	VBP
cord-006229-7yoilsho	5493	11	up	up	IN
cord-006229-7yoilsho	5493	12	to	to	TO
cord-006229-7yoilsho	5493	13	100	100	CD
cord-006229-7yoilsho	5493	14	µl	µl	IN
cord-006229-7yoilsho	5493	15	plasma	plasma	NN
cord-006229-7yoilsho	5493	16	or	or	CC
cord-006229-7yoilsho	5493	17	serum	serum	NN
cord-006229-7yoilsho	5493	18	for	for	IN
cord-006229-7yoilsho	5493	19	a	a	DT
cord-006229-7yoilsho	5493	20	single	single	JJ
cord-006229-7yoilsho	5493	21	measurement	measurement	NN
cord-006229-7yoilsho	5493	22	.	.	.
cord-006229-7yoilsho	5494	1	In	in	IN
cord-006229-7yoilsho	5494	2	order	order	NN
cord-006229-7yoilsho	5494	3	to	to	TO
cord-006229-7yoilsho	5494	4	meet	meet	VB
cord-006229-7yoilsho	5494	5	the	the	DT
cord-006229-7yoilsho	5494	6	general	general	JJ
cord-006229-7yoilsho	5494	7	trend	trend	NN
cord-006229-7yoilsho	5494	8	to	to	TO
cord-006229-7yoilsho	5494	9	include	include	VB
cord-006229-7yoilsho	5494	10	more	more	RBR
cord-006229-7yoilsho	5494	11	relevant	relevant	JJ
cord-006229-7yoilsho	5494	12	parameters	parameter	NNS
cord-006229-7yoilsho	5494	13	in	in	IN
cord-006229-7yoilsho	5494	14	animal	animal	NN
cord-006229-7yoilsho	5494	15	studies	study	NNS
cord-006229-7yoilsho	5494	16	and	and	CC
cord-006229-7yoilsho	5494	17	restrictions	restriction	NNS
cord-006229-7yoilsho	5494	18	through	through	IN
cord-006229-7yoilsho	5494	19	animal	animal	NN
cord-006229-7yoilsho	5494	20	welfare	welfare	NN
cord-006229-7yoilsho	5494	21	requirements	requirement	NNS
cord-006229-7yoilsho	5494	22	to	to	TO
cord-006229-7yoilsho	5494	23	limit	limit	VB
cord-006229-7yoilsho	5494	24	the	the	DT
cord-006229-7yoilsho	5494	25	volume	volume	NN
cord-006229-7yoilsho	5494	26	of	of	IN
cord-006229-7yoilsho	5494	27	interim	interim	JJ
cord-006229-7yoilsho	5494	28	blood	blood	NN
cord-006229-7yoilsho	5494	29	draws	draw	VBZ
cord-006229-7yoilsho	5494	30	we	-PRON-	PRP
cord-006229-7yoilsho	5494	31	explored	explore	VBD
cord-006229-7yoilsho	5494	32	the	the	DT
cord-006229-7yoilsho	5494	33	rat	rat	NN
cord-006229-7yoilsho	5494	34	/	/	SYM
cord-006229-7yoilsho	5494	35	mouse	mouse	NN
cord-006229-7yoilsho	5494	36	insulin	insulin	NNP
cord-006229-7yoilsho	5494	37	singleplex	singleplex	NN
cord-006229-7yoilsho	5494	38	assay	assay	NN
cord-006229-7yoilsho	5494	39	of	of	IN
cord-006229-7yoilsho	5494	40	Meso	Meso	NNP
cord-006229-7yoilsho	5494	41	Scale	Scale	NNP
cord-006229-7yoilsho	5494	42	Discovery	Discovery	NNP
cord-006229-7yoilsho	5494	43	(	(	-LRB-
cord-006229-7yoilsho	5494	44	MSD	MSD	NNP
cord-006229-7yoilsho	5494	45	)	)	-RRB-
cord-006229-7yoilsho	5494	46	as	as	IN
cord-006229-7yoilsho	5494	47	an	an	DT
cord-006229-7yoilsho	5494	48	alternate	alternate	JJ
cord-006229-7yoilsho	5494	49	assay	assay	NN
cord-006229-7yoilsho	5494	50	consuming	consume	VBG
cord-006229-7yoilsho	5494	51	only	only	RB
cord-006229-7yoilsho	5494	52	10	10	CD
cord-006229-7yoilsho	5494	53	µl	µl	IN
cord-006229-7yoilsho	5494	54	serum	serum	NN
cord-006229-7yoilsho	5494	55	or	or	CC
cord-006229-7yoilsho	5494	56	plasma	plasma	NN
cord-006229-7yoilsho	5494	57	or	or	CC
cord-006229-7yoilsho	5494	58	less	less	JJR
cord-006229-7yoilsho	5494	59	for	for	IN
cord-006229-7yoilsho	5494	60	a	a	DT
cord-006229-7yoilsho	5494	61	single	single	JJ
cord-006229-7yoilsho	5494	62	measurement	measurement	NN
cord-006229-7yoilsho	5494	63	.	.	.
cord-006229-7yoilsho	5495	1	The	the	DT
cord-006229-7yoilsho	5495	2	assay	assay	NN
cord-006229-7yoilsho	5495	3	is	be	VBZ
cord-006229-7yoilsho	5495	4	a	a	DT
cord-006229-7yoilsho	5495	5	sandwich	sandwich	NN
cord-006229-7yoilsho	5495	6	immunoassay	immunoassay	NN
cord-006229-7yoilsho	5495	7	,	,	,
cord-006229-7yoilsho	5495	8	whereby	whereby	WRB
cord-006229-7yoilsho	5495	9	insulin	insulin	NN
cord-006229-7yoilsho	5495	10	in	in	IN
cord-006229-7yoilsho	5495	11	the	the	DT
cord-006229-7yoilsho	5495	12	sample	sample	NN
cord-006229-7yoilsho	5495	13	binds	bind	VBZ
cord-006229-7yoilsho	5495	14	to	to	IN
cord-006229-7yoilsho	5495	15	the	the	DT
cord-006229-7yoilsho	5495	16	capture	capture	NN
cord-006229-7yoilsho	5495	17	antibody	antibody	NN
cord-006229-7yoilsho	5495	18	immobilized	immobilize	VBN
cord-006229-7yoilsho	5495	19	on	on	IN
cord-006229-7yoilsho	5495	20	the	the	DT
cord-006229-7yoilsho	5495	21	working	work	VBG
cord-006229-7yoilsho	5495	22	electrode	electrode	NN
cord-006229-7yoilsho	5495	23	surface	surface	NN
cord-006229-7yoilsho	5495	24	at	at	IN
cord-006229-7yoilsho	5495	25	the	the	DT
cord-006229-7yoilsho	5495	26	bottom	bottom	NN
cord-006229-7yoilsho	5495	27	of	of	IN
cord-006229-7yoilsho	5495	28	each	each	DT
cord-006229-7yoilsho	5495	29	well	well	NN
cord-006229-7yoilsho	5495	30	and	and	CC
cord-006229-7yoilsho	5495	31	recruitment	recruitment	NN
cord-006229-7yoilsho	5495	32	of	of	IN
cord-006229-7yoilsho	5495	33	the	the	DT
cord-006229-7yoilsho	5495	34	labeled	label	VBN
cord-006229-7yoilsho	5495	35	detection	detection	NN
cord-006229-7yoilsho	5495	36	antibody	antibody	NN
cord-006229-7yoilsho	5495	37	(	(	-LRB-
cord-006229-7yoilsho	5495	38	anti	anti	JJ
cord-006229-7yoilsho	5495	39	-	-	JJ
cord-006229-7yoilsho	5495	40	insulin	insulin	JJ
cord-006229-7yoilsho	5495	41	labeled	label	VBN
cord-006229-7yoilsho	5495	42	with	with	IN
cord-006229-7yoilsho	5495	43	electrochemiluminescent	electrochemiluminescent	JJ
cord-006229-7yoilsho	5495	44	compound	compound	NN
cord-006229-7yoilsho	5495	45	,	,	,
cord-006229-7yoilsho	5495	46	MSD	MSD	NNP
cord-006229-7yoilsho	5495	47	SULFO	SULFO	NNP
cord-006229-7yoilsho	5495	48	-	-	HYPH
cord-006229-7yoilsho	5495	49	TAG	TAG	NNP
cord-006229-7yoilsho	5495	50	™	™	CD
cord-006229-7yoilsho	5495	51	label	label	NN
cord-006229-7yoilsho	5495	52	)	)	-RRB-
cord-006229-7yoilsho	5495	53	by	by	IN
cord-006229-7yoilsho	5495	54	bound	bind	VBN
cord-006229-7yoilsho	5495	55	analyte	analyte	NN
cord-006229-7yoilsho	5495	56	completes	complete	VBZ
cord-006229-7yoilsho	5495	57	the	the	DT
cord-006229-7yoilsho	5495	58	sandwich	sandwich	NN
cord-006229-7yoilsho	5495	59	.	.	.
cord-006229-7yoilsho	5496	1	Voltage	voltage	NN
cord-006229-7yoilsho	5496	2	applied	apply	VBN
cord-006229-7yoilsho	5496	3	to	to	IN
cord-006229-7yoilsho	5496	4	the	the	DT
cord-006229-7yoilsho	5496	5	plate	plate	NN
cord-006229-7yoilsho	5496	6	electrodes	electrode	NNS
cord-006229-7yoilsho	5496	7	then	then	RB
cord-006229-7yoilsho	5496	8	causes	cause	VBZ
cord-006229-7yoilsho	5496	9	the	the	DT
cord-006229-7yoilsho	5496	10	label	label	NN
cord-006229-7yoilsho	5496	11	bound	bind	VBN
cord-006229-7yoilsho	5496	12	to	to	IN
cord-006229-7yoilsho	5496	13	the	the	DT
cord-006229-7yoilsho	5496	14	electrode	electrode	NN
cord-006229-7yoilsho	5496	15	surface	surface	NN
cord-006229-7yoilsho	5496	16	to	to	TO
cord-006229-7yoilsho	5496	17	emit	emit	VB
cord-006229-7yoilsho	5496	18	light	light	VB
cord-006229-7yoilsho	5496	19	the	the	DT
cord-006229-7yoilsho	5496	20	intensity	intensity	NN
cord-006229-7yoilsho	5496	21	of	of	IN
cord-006229-7yoilsho	5496	22	which	which	WDT
cord-006229-7yoilsho	5496	23	is	be	VBZ
cord-006229-7yoilsho	5496	24	a	a	DT
cord-006229-7yoilsho	5496	25	quantitative	quantitative	JJ
cord-006229-7yoilsho	5496	26	measure	measure	NN
cord-006229-7yoilsho	5496	27	of	of	IN
cord-006229-7yoilsho	5496	28	insulin	insulin	NN
cord-006229-7yoilsho	5496	29	.	.	.
cord-006229-7yoilsho	5497	1	The	the	DT
cord-006229-7yoilsho	5497	2	MSD	MSD	NNP
cord-006229-7yoilsho	5497	3	insulin	insulin	NN
cord-006229-7yoilsho	5497	4	assay	assay	NN
cord-006229-7yoilsho	5497	5	was	be	VBD
cord-006229-7yoilsho	5497	6	characterized	characterize	VBN
cord-006229-7yoilsho	5497	7	by	by	IN
cord-006229-7yoilsho	5497	8	a	a	DT
cord-006229-7yoilsho	5497	9	robust	robust	JJ
cord-006229-7yoilsho	5497	10	calibration	calibration	NN
cord-006229-7yoilsho	5497	11	and	and	CC
cord-006229-7yoilsho	5497	12	only	only	JJ
cord-006229-7yoilsho	5497	13	small	small	JJ
cord-006229-7yoilsho	5497	14	variations	variation	NNS
cord-006229-7yoilsho	5497	15	within	within	IN
cord-006229-7yoilsho	5497	16	repeated	repeat	VBN
cord-006229-7yoilsho	5497	17	measurements	measurement	NNS
cord-006229-7yoilsho	5497	18	.	.	.
cord-006229-7yoilsho	5498	1	The	the	DT
cord-006229-7yoilsho	5498	2	assay	assay	NN
cord-006229-7yoilsho	5498	3	presented	present	VBD
cord-006229-7yoilsho	5498	4	a	a	DT
cord-006229-7yoilsho	5498	5	broad	broad	JJ
cord-006229-7yoilsho	5498	6	dynamic	dynamic	JJ
cord-006229-7yoilsho	5498	7	range	range	NN
cord-006229-7yoilsho	5498	8	and	and	CC
cord-006229-7yoilsho	5498	9	differences	difference	NNS
cord-006229-7yoilsho	5498	10	in	in	IN
cord-006229-7yoilsho	5498	11	insulin	insulin	NN
cord-006229-7yoilsho	5498	12	levels	level	NNS
cord-006229-7yoilsho	5498	13	of	of	IN
cord-006229-7yoilsho	5498	14	normal	normal	JJ
cord-006229-7yoilsho	5498	15	and	and	CC
cord-006229-7yoilsho	5498	16	rats	rat	NNS
cord-006229-7yoilsho	5498	17	suffering	suffer	VBG
cord-006229-7yoilsho	5498	18	from	from	IN
cord-006229-7yoilsho	5498	19	metabolic	metabolic	JJ
cord-006229-7yoilsho	5498	20	syndrome	syndrome	NN
cord-006229-7yoilsho	5498	21	could	could	MD
cord-006229-7yoilsho	5498	22	readily	readily	RB
cord-006229-7yoilsho	5498	23	be	be	VB
cord-006229-7yoilsho	5498	24	demonstrated	demonstrate	VBN
cord-006229-7yoilsho	5498	25	.	.	.
cord-006229-7yoilsho	5499	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	5499	2	,	,	,
cord-006229-7yoilsho	5499	3	the	the	DT
cord-006229-7yoilsho	5499	4	high	high	JJ
cord-006229-7yoilsho	5499	5	sensitivity	sensitivity	NN
cord-006229-7yoilsho	5499	6	may	may	MD
cord-006229-7yoilsho	5499	7	even	even	RB
cord-006229-7yoilsho	5499	8	allow	allow	VB
cord-006229-7yoilsho	5499	9	the	the	DT
cord-006229-7yoilsho	5499	10	use	use	NN
cord-006229-7yoilsho	5499	11	of	of	IN
cord-006229-7yoilsho	5499	12	smaller	small	JJR
cord-006229-7yoilsho	5499	13	sample	sample	NN
cord-006229-7yoilsho	5499	14	volumes	volume	NNS
cord-006229-7yoilsho	5499	15	.	.	.
cord-006229-7yoilsho	5500	1	These	these	DT
cord-006229-7yoilsho	5500	2	features	feature	NNS
cord-006229-7yoilsho	5500	3	render	render	VBP
cord-006229-7yoilsho	5500	4	this	this	DT
cord-006229-7yoilsho	5500	5	assay	assay	NN
cord-006229-7yoilsho	5500	6	an	an	DT
cord-006229-7yoilsho	5500	7	attractive	attractive	JJ
cord-006229-7yoilsho	5500	8	alternative	alternative	NN
cord-006229-7yoilsho	5500	9	for	for	IN
cord-006229-7yoilsho	5500	10	the	the	DT
cord-006229-7yoilsho	5500	11	measurement	measurement	NN
cord-006229-7yoilsho	5500	12	of	of	IN
cord-006229-7yoilsho	5500	13	insulin	insulin	NN
cord-006229-7yoilsho	5500	14	.	.	.
cord-006229-7yoilsho	5501	1	The	the	DT
cord-006229-7yoilsho	5501	2	lack	lack	NN
cord-006229-7yoilsho	5501	3	of	of	IN
cord-006229-7yoilsho	5501	4	corresponding	correspond	VBG
cord-006229-7yoilsho	5501	5	quality	quality	NN
cord-006229-7yoilsho	5501	6	control	control	NN
cord-006229-7yoilsho	5501	7	samples	sample	NNS
cord-006229-7yoilsho	5501	8	for	for	IN
cord-006229-7yoilsho	5501	9	internal	internal	JJ
cord-006229-7yoilsho	5501	10	quality	quality	NN
cord-006229-7yoilsho	5501	11	control	control	NN
cord-006229-7yoilsho	5501	12	may	may	MD
cord-006229-7yoilsho	5501	13	be	be	VB
cord-006229-7yoilsho	5501	14	considered	consider	VBN
cord-006229-7yoilsho	5501	15	as	as	IN
cord-006229-7yoilsho	5501	16	a	a	DT
cord-006229-7yoilsho	5501	17	relative	relative	JJ
cord-006229-7yoilsho	5501	18	drawback	drawback	NN
cord-006229-7yoilsho	5501	19	.	.	.
cord-006229-7yoilsho	5502	1	However	however	RB
cord-006229-7yoilsho	5502	2	,	,	,
cord-006229-7yoilsho	5502	3	the	the	DT
cord-006229-7yoilsho	5502	4	cross	cross	NN
cord-006229-7yoilsho	5502	5	reactivity	reactivity	NN
cord-006229-7yoilsho	5502	6	of	of	IN
cord-006229-7yoilsho	5502	7	the	the	DT
cord-006229-7yoilsho	5502	8	assay	assay	NN
cord-006229-7yoilsho	5502	9	with	with	IN
cord-006229-7yoilsho	5502	10	human	human	JJ
cord-006229-7yoilsho	5502	11	insulin	insulin	NN
cord-006229-7yoilsho	5502	12	provides	provide	VBZ
cord-006229-7yoilsho	5502	13	the	the	DT
cord-006229-7yoilsho	5502	14	opportunity	opportunity	NN
cord-006229-7yoilsho	5502	15	to	to	TO
cord-006229-7yoilsho	5502	16	use	use	VB
cord-006229-7yoilsho	5502	17	QCs	QCs	NNP
cord-006229-7yoilsho	5502	18	designed	design	VBN
cord-006229-7yoilsho	5502	19	for	for	IN
cord-006229-7yoilsho	5502	20	human	human	JJ
cord-006229-7yoilsho	5502	21	assays	assay	NNS
cord-006229-7yoilsho	5502	22	and	and	CC
cord-006229-7yoilsho	5502	23	to	to	TO
cord-006229-7yoilsho	5502	24	possibly	possibly	RB
cord-006229-7yoilsho	5502	25	participate	participate	VB
cord-006229-7yoilsho	5502	26	in	in	IN
cord-006229-7yoilsho	5502	27	ring	ring	NN
cord-006229-7yoilsho	5502	28	trials	trial	NNS
cord-006229-7yoilsho	5502	29	for	for	IN
cord-006229-7yoilsho	5502	30	human	human	JJ
cord-006229-7yoilsho	5502	31	insulin	insulin	NN
cord-006229-7yoilsho	5502	32	for	for	IN
cord-006229-7yoilsho	5502	33	external	external	JJ
cord-006229-7yoilsho	5502	34	quality	quality	NN
cord-006229-7yoilsho	5502	35	control	control	NN
cord-006229-7yoilsho	5502	36	if	if	IN
cord-006229-7yoilsho	5502	37	needed	need	VBN
cord-006229-7yoilsho	5502	38	.	.	.
cord-006229-7yoilsho	5503	1	Surfactants	surfactant	NNS
cord-006229-7yoilsho	5503	2	are	be	VBP
cord-006229-7yoilsho	5503	3	main	main	JJ
cord-006229-7yoilsho	5503	4	constituents	constituent	NNS
cord-006229-7yoilsho	5503	5	of	of	IN
cord-006229-7yoilsho	5503	6	different	different	JJ
cord-006229-7yoilsho	5503	7	consumer	consumer	NN
cord-006229-7yoilsho	5503	8	products	product	NNS
cord-006229-7yoilsho	5503	9	,	,	,
cord-006229-7yoilsho	5503	10	e.g.	e.g.	IN
cord-006229-7yoilsho	5503	11	detergents	detergent	NNS
cord-006229-7yoilsho	5503	12	or	or	CC
cord-006229-7yoilsho	5503	13	cosmetic	cosmetic	JJ
cord-006229-7yoilsho	5503	14	cleansing	cleansing	NN
cord-006229-7yoilsho	5503	15	products	product	NNS
cord-006229-7yoilsho	5503	16	.	.	.
cord-006229-7yoilsho	5504	1	Since	since	IN
cord-006229-7yoilsho	5504	2	surfactants	surfactant	NNS
cord-006229-7yoilsho	5504	3	show	show	VBP
cord-006229-7yoilsho	5504	4	an	an	DT
cord-006229-7yoilsho	5504	5	intrinsic	intrinsic	JJ
cord-006229-7yoilsho	5504	6	skin	skin	NN
cord-006229-7yoilsho	5504	7	irritation	irritation	NN
cord-006229-7yoilsho	5504	8	potential	potential	NN
cord-006229-7yoilsho	5504	9	,	,	,
cord-006229-7yoilsho	5504	10	dilutions	dilution	NNS
cord-006229-7yoilsho	5504	11	are	be	VBP
cord-006229-7yoilsho	5504	12	used	use	VBN
cord-006229-7yoilsho	5504	13	in	in	IN
cord-006229-7yoilsho	5504	14	the	the	DT
cord-006229-7yoilsho	5504	15	final	final	JJ
cord-006229-7yoilsho	5504	16	products	product	NNS
cord-006229-7yoilsho	5504	17	to	to	TO
cord-006229-7yoilsho	5504	18	avoid	avoid	VB
cord-006229-7yoilsho	5504	19	adverse	adverse	JJ
cord-006229-7yoilsho	5504	20	effects	effect	NNS
cord-006229-7yoilsho	5504	21	like	like	IN
cord-006229-7yoilsho	5504	22	irritant	irritant	JJ
cord-006229-7yoilsho	5504	23	contact	contact	NN
cord-006229-7yoilsho	5504	24	dermatitis	dermatitis	NN
cord-006229-7yoilsho	5504	25	from	from	IN
cord-006229-7yoilsho	5504	26	product	product	NN
cord-006229-7yoilsho	5504	27	use	use	NN
cord-006229-7yoilsho	5504	28	.	.	.
cord-006229-7yoilsho	5505	1	In	in	IN
cord-006229-7yoilsho	5505	2	addition	addition	NN
cord-006229-7yoilsho	5505	3	,	,	,
cord-006229-7yoilsho	5505	4	mixtures	mixture	NNS
cord-006229-7yoilsho	5505	5	of	of	IN
cord-006229-7yoilsho	5505	6	different	different	JJ
cord-006229-7yoilsho	5505	7	surfactants	surfactant	NNS
cord-006229-7yoilsho	5505	8	are	be	VBP
cord-006229-7yoilsho	5505	9	typically	typically	RB
cord-006229-7yoilsho	5505	10	formulated	formulate	VBN
cord-006229-7yoilsho	5505	11	,	,	,
cord-006229-7yoilsho	5505	12	as	as	IN
cord-006229-7yoilsho	5505	13	it	-PRON-	PRP
cord-006229-7yoilsho	5505	14	is	be	VBZ
cord-006229-7yoilsho	5505	15	a	a	DT
cord-006229-7yoilsho	5505	16	long	long	RB
cord-006229-7yoilsho	5505	17	-	-	HYPH
cord-006229-7yoilsho	5505	18	standing	stand	VBG
cord-006229-7yoilsho	5505	19	experience	experience	NN
cord-006229-7yoilsho	5505	20	that	that	IN
cord-006229-7yoilsho	5505	21	those	those	DT
cord-006229-7yoilsho	5505	22	mixtures	mixture	NNS
cord-006229-7yoilsho	5505	23	exhibit	exhibit	VBP
cord-006229-7yoilsho	5505	24	much	much	RB
cord-006229-7yoilsho	5505	25	lower	low	JJR
cord-006229-7yoilsho	5505	26	acute	acute	JJ
cord-006229-7yoilsho	5505	27	irritation	irritation	NN
cord-006229-7yoilsho	5505	28	potential	potential	NN
cord-006229-7yoilsho	5505	29	than	than	IN
cord-006229-7yoilsho	5505	30	expected	expect	VBN
cord-006229-7yoilsho	5505	31	from	from	IN
cord-006229-7yoilsho	5505	32	the	the	DT
cord-006229-7yoilsho	5505	33	mere	mere	JJ
cord-006229-7yoilsho	5505	34	summation	summation	NN
cord-006229-7yoilsho	5505	35	of	of	IN
cord-006229-7yoilsho	5505	36	their	-PRON-	PRP$
cord-006229-7yoilsho	5505	37	individual	individual	JJ
cord-006229-7yoilsho	5505	38	irritation	irritation	NN
cord-006229-7yoilsho	5505	39	potential	potential	NN
cord-006229-7yoilsho	5505	40	,	,	,
cord-006229-7yoilsho	5505	41	an	an	DT
cord-006229-7yoilsho	5505	42	effect	effect	NN
cord-006229-7yoilsho	5505	43	coined	coin	VBN
cord-006229-7yoilsho	5505	44	surfactant	surfactant	NN
cord-006229-7yoilsho	5505	45	antagonism	antagonism	NN
cord-006229-7yoilsho	5505	46	.	.	.
cord-006229-7yoilsho	5506	1	Only	only	RB
cord-006229-7yoilsho	5506	2	few	few	JJ
cord-006229-7yoilsho	5506	3	studies	study	NNS
cord-006229-7yoilsho	5506	4	were	be	VBD
cord-006229-7yoilsho	5506	5	performed	perform	VBN
cord-006229-7yoilsho	5506	6	to	to	TO
cord-006229-7yoilsho	5506	7	gain	gain	VB
cord-006229-7yoilsho	5506	8	a	a	DT
cord-006229-7yoilsho	5506	9	more	more	RBR
cord-006229-7yoilsho	5506	10	fundamental	fundamental	JJ
cord-006229-7yoilsho	5506	11	understanding	understanding	NN
cord-006229-7yoilsho	5506	12	of	of	IN
cord-006229-7yoilsho	5506	13	the	the	DT
cord-006229-7yoilsho	5506	14	effect	effect	NN
cord-006229-7yoilsho	5506	15	,	,	,
cord-006229-7yoilsho	5506	16	and	and	CC
cord-006229-7yoilsho	5506	17	it	-PRON-	PRP
cord-006229-7yoilsho	5506	18	's	be	VBZ
cord-006229-7yoilsho	5506	19	mechanistic	mechanistic	JJ
cord-006229-7yoilsho	5506	20	basis	basis	NN
cord-006229-7yoilsho	5506	21	remains	remain	VBZ
cord-006229-7yoilsho	5506	22	unclear	unclear	JJ
cord-006229-7yoilsho	5506	23	.	.	.
cord-006229-7yoilsho	5507	1	However	however	RB
cord-006229-7yoilsho	5507	2	,	,	,
cord-006229-7yoilsho	5507	3	a	a	DT
cord-006229-7yoilsho	5507	4	thorough	thorough	JJ
cord-006229-7yoilsho	5507	5	understanding	understanding	NN
cord-006229-7yoilsho	5507	6	of	of	IN
cord-006229-7yoilsho	5507	7	the	the	DT
cord-006229-7yoilsho	5507	8	surfactant	surfactant	NN
cord-006229-7yoilsho	5507	9	antagonism	antagonism	NN
cord-006229-7yoilsho	5507	10	is	be	VBZ
cord-006229-7yoilsho	5507	11	not	not	RB
cord-006229-7yoilsho	5507	12	only	only	RB
cord-006229-7yoilsho	5507	13	of	of	IN
cord-006229-7yoilsho	5507	14	value	value	NN
cord-006229-7yoilsho	5507	15	for	for	IN
cord-006229-7yoilsho	5507	16	the	the	DT
cord-006229-7yoilsho	5507	17	formulation	formulation	NN
cord-006229-7yoilsho	5507	18	of	of	IN
cord-006229-7yoilsho	5507	19	products	product	NNS
cord-006229-7yoilsho	5507	20	that	that	WDT
cord-006229-7yoilsho	5507	21	are	be	VBP
cord-006229-7yoilsho	5507	22	considered	consider	VBN
cord-006229-7yoilsho	5507	23	'	'	``
cord-006229-7yoilsho	5507	24	mild	mild	JJ
cord-006229-7yoilsho	5507	25	to	to	IN
cord-006229-7yoilsho	5507	26	the	the	DT
cord-006229-7yoilsho	5507	27	skin	skin	NN
cord-006229-7yoilsho	5507	28	'	'	''
cord-006229-7yoilsho	5507	29	.	.	.
cord-006229-7yoilsho	5508	1	It	-PRON-	PRP
cord-006229-7yoilsho	5508	2	is	be	VBZ
cord-006229-7yoilsho	5508	3	also	also	RB
cord-006229-7yoilsho	5508	4	important	important	JJ
cord-006229-7yoilsho	5508	5	for	for	IN
cord-006229-7yoilsho	5508	6	the	the	DT
cord-006229-7yoilsho	5508	7	classification	classification	NN
cord-006229-7yoilsho	5508	8	of	of	IN
cord-006229-7yoilsho	5508	9	products	product	NNS
cord-006229-7yoilsho	5508	10	according	accord	VBG
cord-006229-7yoilsho	5508	11	to	to	IN
cord-006229-7yoilsho	5508	12	the	the	DT
cord-006229-7yoilsho	5508	13	CLP	CLP	NNP
cord-006229-7yoilsho	5508	14	Regulation	Regulation	NNP
cord-006229-7yoilsho	5508	15	in	in	IN
cord-006229-7yoilsho	5508	16	cases	case	NNS
cord-006229-7yoilsho	5508	17	when	when	WRB
cord-006229-7yoilsho	5508	18	data	datum	NNS
cord-006229-7yoilsho	5508	19	of	of	IN
cord-006229-7yoilsho	5508	20	the	the	DT
cord-006229-7yoilsho	5508	21	mixtures	mixture	NNS
cord-006229-7yoilsho	5508	22	is	be	VBZ
cord-006229-7yoilsho	5508	23	missing	miss	VBG
cord-006229-7yoilsho	5508	24	,	,	,
cord-006229-7yoilsho	5508	25	because	because	IN
cord-006229-7yoilsho	5508	26	summation	summation	NN
cord-006229-7yoilsho	5508	27	of	of	IN
cord-006229-7yoilsho	5508	28	the	the	DT
cord-006229-7yoilsho	5508	29	ingredients	ingredient	NNS
cord-006229-7yoilsho	5508	30	'	'	POS
cord-006229-7yoilsho	5508	31	irritating	irritating	JJ
cord-006229-7yoilsho	5508	32	effects	effect	NNS
cord-006229-7yoilsho	5508	33	usually	usually	RB
cord-006229-7yoilsho	5508	34	results	result	VBZ
cord-006229-7yoilsho	5508	35	in	in	IN
cord-006229-7yoilsho	5508	36	over	over	IN
cord-006229-7yoilsho	5508	37	-	-	HYPH
cord-006229-7yoilsho	5508	38	classification	classification	NN
cord-006229-7yoilsho	5508	39	as	as	IN
cord-006229-7yoilsho	5508	40	skin	skin	NN
cord-006229-7yoilsho	5508	41	irritant	irritant	NN
cord-006229-7yoilsho	5508	42	.	.	.
cord-006229-7yoilsho	5509	1	Due	due	IN
cord-006229-7yoilsho	5509	2	to	to	IN
cord-006229-7yoilsho	5509	3	the	the	DT
cord-006229-7yoilsho	5509	4	progress	progress	NN
cord-006229-7yoilsho	5509	5	in	in	IN
cord-006229-7yoilsho	5509	6	the	the	DT
cord-006229-7yoilsho	5509	7	development	development	NN
cord-006229-7yoilsho	5509	8	of	of	IN
cord-006229-7yoilsho	5509	9	alternatives	alternative	NNS
cord-006229-7yoilsho	5509	10	to	to	IN
cord-006229-7yoilsho	5509	11	animal	animal	NN
cord-006229-7yoilsho	5509	12	testing	testing	NN
cord-006229-7yoilsho	5509	13	,	,	,
cord-006229-7yoilsho	5509	14	different	different	JJ
cord-006229-7yoilsho	5509	15	in	in	IN
cord-006229-7yoilsho	5509	16	vitro	vitro	FW
cord-006229-7yoilsho	5509	17	methods	method	NNS
cord-006229-7yoilsho	5509	18	have	have	VBP
cord-006229-7yoilsho	5509	19	become	become	VBN
cord-006229-7yoilsho	5509	20	available	available	JJ
cord-006229-7yoilsho	5509	21	to	to	TO
cord-006229-7yoilsho	5509	22	determine	determine	VB
cord-006229-7yoilsho	5509	23	skin	skin	NN
cord-006229-7yoilsho	5509	24	irritating	irritating	JJ
cord-006229-7yoilsho	5509	25	properties	property	NNS
cord-006229-7yoilsho	5509	26	of	of	IN
cord-006229-7yoilsho	5509	27	substances	substance	NNS
cord-006229-7yoilsho	5509	28	.	.	.
cord-006229-7yoilsho	5510	1	Methods	method	NNS
cord-006229-7yoilsho	5510	2	like	like	IN
cord-006229-7yoilsho	5510	3	the	the	DT
cord-006229-7yoilsho	5510	4	OECD	OECD	NNP
cord-006229-7yoilsho	5510	5	TG	TG	NNP
cord-006229-7yoilsho	5510	6	431	431	CD
cord-006229-7yoilsho	5510	7	and	and	CC
cord-006229-7yoilsho	5510	8	439	439	CD
cord-006229-7yoilsho	5510	9	especially	especially	RB
cord-006229-7yoilsho	5510	10	aim	aim	VBP
cord-006229-7yoilsho	5510	11	at	at	IN
cord-006229-7yoilsho	5510	12	deriving	derive	VBG
cord-006229-7yoilsho	5510	13	a	a	DT
cord-006229-7yoilsho	5510	14	classification	classification	NN
cord-006229-7yoilsho	5510	15	for	for	IN
cord-006229-7yoilsho	5510	16	skin	skin	NN
cord-006229-7yoilsho	5510	17	irritation	irritation	NN
cord-006229-7yoilsho	5510	18	/	/	SYM
cord-006229-7yoilsho	5510	19	corrosion	corrosion	NN
cord-006229-7yoilsho	5510	20	effects	effect	NNS
cord-006229-7yoilsho	5510	21	according	accord	VBG
cord-006229-7yoilsho	5510	22	to	to	IN
cord-006229-7yoilsho	5510	23	the	the	DT
cord-006229-7yoilsho	5510	24	CLP	CLP	NNP
cord-006229-7yoilsho	5510	25	Regulation	Regulation	NNP
cord-006229-7yoilsho	5510	26	.	.	.
cord-006229-7yoilsho	5511	1	However	however	RB
cord-006229-7yoilsho	5511	2	,	,	,
cord-006229-7yoilsho	5511	3	even	even	RB
cord-006229-7yoilsho	5511	4	though	though	IN
cord-006229-7yoilsho	5511	5	these	these	DT
cord-006229-7yoilsho	5511	6	methods	method	NNS
cord-006229-7yoilsho	5511	7	became	become	VBD
cord-006229-7yoilsho	5511	8	the	the	DT
cord-006229-7yoilsho	5511	9	preferred	preferred	JJ
cord-006229-7yoilsho	5511	10	test	test	NN
cord-006229-7yoilsho	5511	11	methods	method	NNS
cord-006229-7yoilsho	5511	12	for	for	IN
cord-006229-7yoilsho	5511	13	skin	skin	NN
cord-006229-7yoilsho	5511	14	irritation	irritation	NN
cord-006229-7yoilsho	5511	15	testing	testing	NN
cord-006229-7yoilsho	5511	16	,	,	,
cord-006229-7yoilsho	5511	17	to	to	IN
cord-006229-7yoilsho	5511	18	our	-PRON-	PRP$
cord-006229-7yoilsho	5511	19	knowledge	knowledge	NN
cord-006229-7yoilsho	5511	20	hitherto	hitherto	VBN
cord-006229-7yoilsho	5511	21	isolated	isolate	VBN
cord-006229-7yoilsho	5511	22	investigations	investigation	NNS
cord-006229-7yoilsho	5511	23	on	on	IN
cord-006229-7yoilsho	5511	24	the	the	DT
cord-006229-7yoilsho	5511	25	surfactant	surfactant	NN
cord-006229-7yoilsho	5511	26	antagonism	antagonism	NN
cord-006229-7yoilsho	5511	27	were	be	VBD
cord-006229-7yoilsho	5511	28	only	only	RB
cord-006229-7yoilsho	5511	29	performed	perform	VBN
cord-006229-7yoilsho	5511	30	either	either	CC
cord-006229-7yoilsho	5511	31	by	by	IN
cord-006229-7yoilsho	5511	32	human	human	JJ
cord-006229-7yoilsho	5511	33	patch	patch	NN
cord-006229-7yoilsho	5511	34	test	test	NN
cord-006229-7yoilsho	5511	35	studies	study	NNS
cord-006229-7yoilsho	5511	36	or	or	CC
cord-006229-7yoilsho	5511	37	by	by	IN
cord-006229-7yoilsho	5511	38	non	non	JJ
cord-006229-7yoilsho	5511	39	-	-	JJ
cord-006229-7yoilsho	5511	40	standard	standard	JJ
cord-006229-7yoilsho	5511	41	in	in	IN
cord-006229-7yoilsho	5511	42	vitro	vitro	FW
cord-006229-7yoilsho	5511	43	assays	assay	NNS
cord-006229-7yoilsho	5511	44	.	.	.
cord-006229-7yoilsho	5512	1	In	in	IN
cord-006229-7yoilsho	5512	2	this	this	DT
cord-006229-7yoilsho	5512	3	study	study	NN
cord-006229-7yoilsho	5512	4	,	,	,
cord-006229-7yoilsho	5512	5	the	the	DT
cord-006229-7yoilsho	5512	6	irritation	irritation	NN
cord-006229-7yoilsho	5512	7	potential	potential	NN
cord-006229-7yoilsho	5512	8	of	of	IN
cord-006229-7yoilsho	5512	9	binary	binary	JJ
cord-006229-7yoilsho	5512	10	mixtures	mixture	NNS
cord-006229-7yoilsho	5512	11	of	of	IN
cord-006229-7yoilsho	5512	12	sodium	sodium	NN
cord-006229-7yoilsho	5512	13	dodecylsulfate	dodecylsulfate	NNP
cord-006229-7yoilsho	5512	14	(	(	-LRB-
cord-006229-7yoilsho	5512	15	SDS	SDS	NNP
cord-006229-7yoilsho	5512	16	)	)	-RRB-
cord-006229-7yoilsho	5512	17	,	,	,
cord-006229-7yoilsho	5512	18	linear	linear	NNP
cord-006229-7yoilsho	5512	19	alkylbezene	alkylbezene	NNP
cord-006229-7yoilsho	5512	20	sulfate	sulfate	NN
cord-006229-7yoilsho	5512	21	(	(	-LRB-
cord-006229-7yoilsho	5512	22	LAS	LAS	NNP
cord-006229-7yoilsho	5512	23	)	)	-RRB-
cord-006229-7yoilsho	5512	24	,	,	,
cord-006229-7yoilsho	5512	25	cocamidopropyl	cocamidopropyl	NN
cord-006229-7yoilsho	5512	26	betaine	betaine	NN
cord-006229-7yoilsho	5512	27	(	(	-LRB-
cord-006229-7yoilsho	5512	28	CABP	CABP	NNP
cord-006229-7yoilsho	5512	29	)	)	-RRB-
cord-006229-7yoilsho	5512	30	and	and	CC
cord-006229-7yoilsho	5512	31	alkylpolyglucosid	alkylpolyglucosid	NN
cord-006229-7yoilsho	5512	32	(	(	-LRB-
cord-006229-7yoilsho	5512	33	APG	APG	NNP
cord-006229-7yoilsho	5512	34	)	)	-RRB-
cord-006229-7yoilsho	5512	35	compared	compare	VBN
cord-006229-7yoilsho	5512	36	to	to	IN
cord-006229-7yoilsho	5512	37	the	the	DT
cord-006229-7yoilsho	5512	38	single	single	JJ
cord-006229-7yoilsho	5512	39	compounds	compound	NNS
cord-006229-7yoilsho	5512	40	was	be	VBD
cord-006229-7yoilsho	5512	41	investigated	investigate	VBN
cord-006229-7yoilsho	5512	42	using	use	VBG
cord-006229-7yoilsho	5512	43	Open	Open	NNP
cord-006229-7yoilsho	5512	44	Source	source	NN
cord-006229-7yoilsho	5512	45	Reconstructed	reconstruct	VBN
cord-006229-7yoilsho	5512	46	Epidermis	Epidermis	NNP
cord-006229-7yoilsho	5512	47	(	(	-LRB-
cord-006229-7yoilsho	5512	48	OS	OS	NNP
cord-006229-7yoilsho	5512	49	-	-	HYPH
cord-006229-7yoilsho	5512	50	REp	REp	NNS
cord-006229-7yoilsho	5512	51	)	)	-RRB-
cord-006229-7yoilsho	5512	52	models	model	NNS
cord-006229-7yoilsho	5512	53	.	.	.
cord-006229-7yoilsho	5513	1	Combinations	combination	NNS
cord-006229-7yoilsho	5513	2	of	of	IN
cord-006229-7yoilsho	5513	3	SDS	SDS	NNP
cord-006229-7yoilsho	5513	4	or	or	CC
cord-006229-7yoilsho	5513	5	LAS	LAS	NNP
cord-006229-7yoilsho	5513	6	with	with	IN
cord-006229-7yoilsho	5513	7	CABP	CABP	NNP
cord-006229-7yoilsho	5513	8	and	and	CC
cord-006229-7yoilsho	5513	9	APG	APG	NNP
cord-006229-7yoilsho	5513	10	,	,	,
cord-006229-7yoilsho	5513	11	respectively	respectively	RB
cord-006229-7yoilsho	5513	12	,	,	,
cord-006229-7yoilsho	5513	13	resulted	result	VBD
cord-006229-7yoilsho	5513	14	in	in	IN
cord-006229-7yoilsho	5513	15	a	a	DT
cord-006229-7yoilsho	5513	16	clear	clear	JJ
cord-006229-7yoilsho	5513	17	decrease	decrease	NN
cord-006229-7yoilsho	5513	18	of	of	IN
cord-006229-7yoilsho	5513	19	the	the	DT
cord-006229-7yoilsho	5513	20	irritation	irritation	NN
cord-006229-7yoilsho	5513	21	potential	potential	NN
cord-006229-7yoilsho	5513	22	compared	compare	VBN
cord-006229-7yoilsho	5513	23	to	to	IN
cord-006229-7yoilsho	5513	24	the	the	DT
cord-006229-7yoilsho	5513	25	irritation	irritation	NN
cord-006229-7yoilsho	5513	26	exerted	exert	VBN
cord-006229-7yoilsho	5513	27	by	by	IN
cord-006229-7yoilsho	5513	28	the	the	DT
cord-006229-7yoilsho	5513	29	single	single	JJ
cord-006229-7yoilsho	5513	30	surfactants	surfactant	NNS
cord-006229-7yoilsho	5513	31	,	,	,
cord-006229-7yoilsho	5513	32	even	even	RB
cord-006229-7yoilsho	5513	33	though	though	IN
cord-006229-7yoilsho	5513	34	the	the	DT
cord-006229-7yoilsho	5513	35	total	total	JJ
cord-006229-7yoilsho	5513	36	surfactant	surfactant	NN
cord-006229-7yoilsho	5513	37	concentration	concentration	NN
cord-006229-7yoilsho	5513	38	was	be	VBD
cord-006229-7yoilsho	5513	39	higher	high	JJR
cord-006229-7yoilsho	5513	40	in	in	IN
cord-006229-7yoilsho	5513	41	the	the	DT
cord-006229-7yoilsho	5513	42	mixtures	mixture	NNS
cord-006229-7yoilsho	5513	43	.	.	.
cord-006229-7yoilsho	5514	1	In	in	IN
cord-006229-7yoilsho	5514	2	addition	addition	NN
cord-006229-7yoilsho	5514	3	,	,	,
cord-006229-7yoilsho	5514	4	the	the	DT
cord-006229-7yoilsho	5514	5	effect	effect	NN
cord-006229-7yoilsho	5514	6	of	of	IN
cord-006229-7yoilsho	5514	7	surfactant	surfactant	NN
cord-006229-7yoilsho	5514	8	antagonism	antagonism	NN
cord-006229-7yoilsho	5514	9	was	be	VBD
cord-006229-7yoilsho	5514	10	also	also	RB
cord-006229-7yoilsho	5514	11	observed	observe	VBN
cord-006229-7yoilsho	5514	12	in	in	IN
cord-006229-7yoilsho	5514	13	a	a	DT
cord-006229-7yoilsho	5514	14	mixture	mixture	NN
cord-006229-7yoilsho	5514	15	of	of	IN
cord-006229-7yoilsho	5514	16	CABP	CABP	NNP
cord-006229-7yoilsho	5514	17	and	and	CC
cord-006229-7yoilsho	5514	18	APG	APG	NNP
cord-006229-7yoilsho	5514	19	.	.	.
cord-006229-7yoilsho	5515	1	The	the	DT
cord-006229-7yoilsho	5515	2	reduced	reduce	VBN
cord-006229-7yoilsho	5515	3	irritation	irritation	NN
cord-006229-7yoilsho	5515	4	potential	potential	NN
cord-006229-7yoilsho	5515	5	of	of	IN
cord-006229-7yoilsho	5515	6	mixed	mixed	JJ
cord-006229-7yoilsho	5515	7	surfactants	surfactant	NNS
cord-006229-7yoilsho	5515	8	came	come	VBD
cord-006229-7yoilsho	5515	9	along	along	RB
cord-006229-7yoilsho	5515	10	with	with	IN
cord-006229-7yoilsho	5515	11	both	both	CC
cord-006229-7yoilsho	5515	12	reduced	reduce	VBN
cord-006229-7yoilsho	5515	13	skin	skin	NN
cord-006229-7yoilsho	5515	14	penetration	penetration	NN
cord-006229-7yoilsho	5515	15	of	of	IN
cord-006229-7yoilsho	5515	16	fluorescein	fluorescein	NN
cord-006229-7yoilsho	5515	17	and	and	CC
cord-006229-7yoilsho	5515	18	reduced	reduce	VBN
cord-006229-7yoilsho	5515	19	release	release	NN
cord-006229-7yoilsho	5515	20	of	of	IN
cord-006229-7yoilsho	5515	21	LDH	LDH	NNP
cord-006229-7yoilsho	5515	22	.	.	.
cord-006229-7yoilsho	5516	1	Since	since	IN
cord-006229-7yoilsho	5516	2	no	no	DT
cord-006229-7yoilsho	5516	3	surfactant	surfactant	NN
cord-006229-7yoilsho	5516	4	antagonism	antagonism	NN
cord-006229-7yoilsho	5516	5	is	be	VBZ
cord-006229-7yoilsho	5516	6	observed	observe	VBN
cord-006229-7yoilsho	5516	7	in	in	IN
cord-006229-7yoilsho	5516	8	monolayer	monolayer	NN
cord-006229-7yoilsho	5516	9	cultures	culture	NNS
cord-006229-7yoilsho	5516	10	of	of	IN
cord-006229-7yoilsho	5516	11	keratinocytes	keratinocyte	NNS
cord-006229-7yoilsho	5516	12	that	that	WDT
cord-006229-7yoilsho	5516	13	were	be	VBD
cord-006229-7yoilsho	5516	14	exposed	expose	VBN
cord-006229-7yoilsho	5516	15	to	to	IN
cord-006229-7yoilsho	5516	16	mixtures	mixture	NNS
cord-006229-7yoilsho	5516	17	of	of	IN
cord-006229-7yoilsho	5516	18	surfactants	surfactant	NNS
cord-006229-7yoilsho	5516	19	,	,	,
cord-006229-7yoilsho	5516	20	it	-PRON-	PRP
cord-006229-7yoilsho	5516	21	is	be	VBZ
cord-006229-7yoilsho	5516	22	assumed	assume	VBN
cord-006229-7yoilsho	5516	23	that	that	IN
cord-006229-7yoilsho	5516	24	keratinocytes	keratinocyte	NNS
cord-006229-7yoilsho	5516	25	in	in	IN
cord-006229-7yoilsho	5516	26	the	the	DT
cord-006229-7yoilsho	5516	27	viable	viable	JJ
cord-006229-7yoilsho	5516	28	parts	part	NNS
cord-006229-7yoilsho	5516	29	of	of	IN
cord-006229-7yoilsho	5516	30	the	the	DT
cord-006229-7yoilsho	5516	31	reconstructed	reconstruct	VBN
cord-006229-7yoilsho	5516	32	epidermis	epidermis	NN
cord-006229-7yoilsho	5516	33	are	be	VBP
cord-006229-7yoilsho	5516	34	promptly	promptly	RB
cord-006229-7yoilsho	5516	35	damaged	damage	VBN
cord-006229-7yoilsho	5516	36	by	by	IN
cord-006229-7yoilsho	5516	37	the	the	DT
cord-006229-7yoilsho	5516	38	surfactants	surfactant	NNS
cord-006229-7yoilsho	5516	39	once	once	IN
cord-006229-7yoilsho	5516	40	the	the	DT
cord-006229-7yoilsho	5516	41	model	model	NN
cord-006229-7yoilsho	5516	42	's	's	POS
cord-006229-7yoilsho	5516	43	barrier	barrier	NN
cord-006229-7yoilsho	5516	44	is	be	VBZ
cord-006229-7yoilsho	5516	45	destroyed	destroy	VBN
cord-006229-7yoilsho	5516	46	.	.	.
cord-006229-7yoilsho	5517	1	Hence	hence	RB
cord-006229-7yoilsho	5517	2	,	,	,
cord-006229-7yoilsho	5517	3	surfactant	surfactant	NN
cord-006229-7yoilsho	5517	4	antagonism	antagonism	NN
cord-006229-7yoilsho	5517	5	appears	appear	VBZ
cord-006229-7yoilsho	5517	6	to	to	TO
cord-006229-7yoilsho	5517	7	be	be	VB
cord-006229-7yoilsho	5517	8	primarily	primarily	RB
cord-006229-7yoilsho	5517	9	driven	drive	VBN
cord-006229-7yoilsho	5517	10	by	by	IN
cord-006229-7yoilsho	5517	11	the	the	DT
cord-006229-7yoilsho	5517	12	mixture	mixture	NN
cord-006229-7yoilsho	5517	13	's	's	POS
cord-006229-7yoilsho	5517	14	lower	low	JJR
cord-006229-7yoilsho	5517	15	ability	ability	NN
cord-006229-7yoilsho	5517	16	to	to	TO
cord-006229-7yoilsho	5517	17	damage	damage	VB
cord-006229-7yoilsho	5517	18	the	the	DT
cord-006229-7yoilsho	5517	19	skin	skin	NN
cord-006229-7yoilsho	5517	20	model	model	NN
cord-006229-7yoilsho	5517	21	's	's	POS
cord-006229-7yoilsho	5517	22	barrier	barrier	NN
cord-006229-7yoilsho	5517	23	.	.	.
cord-006229-7yoilsho	5518	1	The	the	DT
cord-006229-7yoilsho	5518	2	micronucleus	micronucleu	NNS
cord-006229-7yoilsho	5518	3	(	(	-LRB-
cord-006229-7yoilsho	5518	4	MN	MN	NNP
cord-006229-7yoilsho	5518	5	)	)	-RRB-
cord-006229-7yoilsho	5518	6	test	test	NN
cord-006229-7yoilsho	5518	7	is	be	VBZ
cord-006229-7yoilsho	5518	8	a	a	DT
cord-006229-7yoilsho	5518	9	reliable	reliable	JJ
cord-006229-7yoilsho	5518	10	method	method	NN
cord-006229-7yoilsho	5518	11	for	for	IN
cord-006229-7yoilsho	5518	12	the	the	DT
cord-006229-7yoilsho	5518	13	detection	detection	NN
cord-006229-7yoilsho	5518	14	of	of	IN
cord-006229-7yoilsho	5518	15	cytogenetic	cytogenetic	JJ
cord-006229-7yoilsho	5518	16	damage	damage	NN
cord-006229-7yoilsho	5518	17	in	in	IN
cord-006229-7yoilsho	5518	18	proliferating	proliferate	VBG
cord-006229-7yoilsho	5518	19	cells	cell	NNS
cord-006229-7yoilsho	5518	20	.	.	.
cord-006229-7yoilsho	5519	1	In	in	IN
cord-006229-7yoilsho	5519	2	recent	recent	JJ
cord-006229-7yoilsho	5519	3	years	year	NNS
cord-006229-7yoilsho	5519	4	,	,	,
cord-006229-7yoilsho	5519	5	substantial	substantial	JJ
cord-006229-7yoilsho	5519	6	progress	progress	NN
cord-006229-7yoilsho	5519	7	has	have	VBZ
cord-006229-7yoilsho	5519	8	been	be	VBN
cord-006229-7yoilsho	5519	9	made	make	VBN
cord-006229-7yoilsho	5519	10	on	on	IN
cord-006229-7yoilsho	5519	11	automated	automate	VBN
cord-006229-7yoilsho	5519	12	,	,	,
cord-006229-7yoilsho	5519	13	thus	thus	RB
cord-006229-7yoilsho	5519	14	faster	fast	RBR
cord-006229-7yoilsho	5519	15	and	and	CC
cord-006229-7yoilsho	5519	16	more	more	RBR
cord-006229-7yoilsho	5519	17	objective	objective	JJ
cord-006229-7yoilsho	5519	18	scoring	scoring	NN
cord-006229-7yoilsho	5519	19	of	of	IN
cord-006229-7yoilsho	5519	20	MN	MN	NNP
cord-006229-7yoilsho	5519	21	test	test	NN
cord-006229-7yoilsho	5519	22	samples	sample	NNS
cord-006229-7yoilsho	5519	23	,	,	,
cord-006229-7yoilsho	5519	24	i.e.	i.e.	FW
cord-006229-7yoilsho	5519	25	,	,	,
cord-006229-7yoilsho	5519	26	methods	method	NNS
cord-006229-7yoilsho	5519	27	based	base	VBN
cord-006229-7yoilsho	5519	28	on	on	IN
cord-006229-7yoilsho	5519	29	flow	flow	NN
cord-006229-7yoilsho	5519	30	cytometry	cytometry	NN
cord-006229-7yoilsho	5519	31	.	.	.
cord-006229-7yoilsho	5520	1	The	the	DT
cord-006229-7yoilsho	5520	2	aim	aim	NN
cord-006229-7yoilsho	5520	3	of	of	IN
cord-006229-7yoilsho	5520	4	the	the	DT
cord-006229-7yoilsho	5520	5	present	present	JJ
cord-006229-7yoilsho	5520	6	study	study	NN
cord-006229-7yoilsho	5520	7	was	be	VBD
cord-006229-7yoilsho	5520	8	to	to	TO
cord-006229-7yoilsho	5520	9	use	use	VB
cord-006229-7yoilsho	5520	10	the	the	DT
cord-006229-7yoilsho	5520	11	adherently	adherently	RB
cord-006229-7yoilsho	5520	12	growing	grow	VBG
cord-006229-7yoilsho	5520	13	human	human	JJ
cord-006229-7yoilsho	5520	14	bladder	bladder	NN
cord-006229-7yoilsho	5520	15	cancer	cancer	NN
cord-006229-7yoilsho	5520	16	cell	cell	NN
cord-006229-7yoilsho	5520	17	line	line	NN
cord-006229-7yoilsho	5520	18	RT4	rt4	NN
cord-006229-7yoilsho	5520	19	to	to	TO
cord-006229-7yoilsho	5520	20	carry	carry	VB
cord-006229-7yoilsho	5520	21	out	out	RP
cord-006229-7yoilsho	5520	22	a	a	DT
cord-006229-7yoilsho	5520	23	comparison	comparison	NN
cord-006229-7yoilsho	5520	24	between	between	IN
cord-006229-7yoilsho	5520	25	traditional	traditional	JJ
cord-006229-7yoilsho	5520	26	(	(	-LRB-
cord-006229-7yoilsho	5520	27	fluorescence	fluorescence	NN
cord-006229-7yoilsho	5520	28	microscopy	microscopy	NNS
cord-006229-7yoilsho	5520	29	)	)	-RRB-
cord-006229-7yoilsho	5520	30	and	and	CC
cord-006229-7yoilsho	5520	31	automated	automate	VBN
cord-006229-7yoilsho	5520	32	(	(	-LRB-
cord-006229-7yoilsho	5520	33	flow	flow	NN
cord-006229-7yoilsho	5520	34	cytometry	cytometry	NN
cord-006229-7yoilsho	5520	35	)	)	-RRB-
cord-006229-7yoilsho	5520	36	MN	MN	NNP
cord-006229-7yoilsho	5520	37	scoring	scoring	NN
cord-006229-7yoilsho	5520	38	.	.	.
cord-006229-7yoilsho	5521	1	For	for	IN
cord-006229-7yoilsho	5521	2	this	this	DT
cord-006229-7yoilsho	5521	3	purpose	purpose	NN
cord-006229-7yoilsho	5521	4	,	,	,
cord-006229-7yoilsho	5521	5	different	different	JJ
cord-006229-7yoilsho	5521	6	substances	substance	NNS
cord-006229-7yoilsho	5521	7	which	which	WDT
cord-006229-7yoilsho	5521	8	are	be	VBP
cord-006229-7yoilsho	5521	9	known	know	VBN
cord-006229-7yoilsho	5521	10	to	to	TO
cord-006229-7yoilsho	5521	11	be	be	VB
cord-006229-7yoilsho	5521	12	positive	positive	JJ
cord-006229-7yoilsho	5521	13	controls	control	NNS
cord-006229-7yoilsho	5521	14	were	be	VBD
cord-006229-7yoilsho	5521	15	used	use	VBN
cord-006229-7yoilsho	5521	16	.	.	.
cord-006229-7yoilsho	5522	1	RT4	rt4	NN
cord-006229-7yoilsho	5522	2	cells	cell	NNS
cord-006229-7yoilsho	5522	3	were	be	VBD
cord-006229-7yoilsho	5522	4	either	either	CC
cord-006229-7yoilsho	5522	5	continuously	continuously	RB
cord-006229-7yoilsho	5522	6	incubated	incubate	VBN
cord-006229-7yoilsho	5522	7	for	for	IN
cord-006229-7yoilsho	5522	8	72	72	CD
cord-006229-7yoilsho	5522	9	h	h	NN
cord-006229-7yoilsho	5522	10	(	(	-LRB-
cord-006229-7yoilsho	5522	11	approximately	approximately	RB
cord-006229-7yoilsho	5522	12	1.5	1.5	CD
cord-006229-7yoilsho	5522	13	cell	cell	NN
cord-006229-7yoilsho	5522	14	cycles	cycle	NNS
cord-006229-7yoilsho	5522	15	duration	duration	NN
cord-006229-7yoilsho	5522	16	)	)	-RRB-
cord-006229-7yoilsho	5522	17	with	with	IN
cord-006229-7yoilsho	5522	18	methyl	methyl	NN
cord-006229-7yoilsho	5522	19	methanesulfonate	methanesulfonate	NN
cord-006229-7yoilsho	5522	20	(	(	-LRB-
cord-006229-7yoilsho	5522	21	MMS	MMS	NNP
cord-006229-7yoilsho	5522	22	;	;	:
cord-006229-7yoilsho	5522	23	50	50	CD
cord-006229-7yoilsho	5522	24	-	-	HYPH
cord-006229-7yoilsho	5522	25	200	200	CD
cord-006229-7yoilsho	5522	26	µM	µm	NN
cord-006229-7yoilsho	5522	27	)	)	-RRB-
cord-006229-7yoilsho	5522	28	,	,	.
cord-006229-7yoilsho	5523	1	benzo[a]pyrene	benzo[a]pyrene	NN
cord-006229-7yoilsho	5523	2	(	(	-LRB-
cord-006229-7yoilsho	5523	3	B[a]P	B[a]P	NNP
cord-006229-7yoilsho	5523	4	;	;	:
cord-006229-7yoilsho	5523	5	0.1	0.1	CD
cord-006229-7yoilsho	5523	6	-	-	SYM
cord-006229-7yoilsho	5523	7	1	1	CD
cord-006229-7yoilsho	5523	8	µM	µm	CD
cord-006229-7yoilsho	5523	9	)	)	-RRB-
cord-006229-7yoilsho	5523	10	,	,	,
cord-006229-7yoilsho	5523	11	vincristine	vincristine	FW
cord-006229-7yoilsho	5523	12	(	(	-LRB-
cord-006229-7yoilsho	5523	13	3	3	CD
cord-006229-7yoilsho	5523	14	-	-	SYM
cord-006229-7yoilsho	5523	15	20	20	CD
cord-006229-7yoilsho	5523	16	nM	nM	NNP
cord-006229-7yoilsho	5523	17	)	)	-RRB-
cord-006229-7yoilsho	5523	18	,	,	,
cord-006229-7yoilsho	5523	19	and	and	CC
cord-006229-7yoilsho	5523	20	colcemid	colcemid	NNP
cord-006229-7yoilsho	5523	21	(	(	-LRB-
cord-006229-7yoilsho	5523	22	10	10	CD
cord-006229-7yoilsho	5523	23	-	-	SYM
cord-006229-7yoilsho	5523	24	20	20	CD
cord-006229-7yoilsho	5523	25	nM	nm	NN
cord-006229-7yoilsho	5523	26	)	)	-RRB-
cord-006229-7yoilsho	5523	27	or	or	CC
cord-006229-7yoilsho	5524	1	cells	cell	NNS
cord-006229-7yoilsho	5524	2	were	be	VBD
cord-006229-7yoilsho	5524	3	irradiated	irradiate	VBN
cord-006229-7yoilsho	5524	4	with	with	IN
cord-006229-7yoilsho	5524	5	Xrays	xray	NNS
cord-006229-7yoilsho	5524	6	(	(	-LRB-
cord-006229-7yoilsho	5524	7	0.5	0.5	CD
cord-006229-7yoilsho	5524	8	-	-	SYM
cord-006229-7yoilsho	5524	9	2	2	CD
cord-006229-7yoilsho	5524	10	Sv	Sv	NNP
cord-006229-7yoilsho	5524	11	)	)	-RRB-
cord-006229-7yoilsho	5524	12	and	and	CC
cord-006229-7yoilsho	5524	13	then	then	RB
cord-006229-7yoilsho	5524	14	cultured	cultured	JJ
cord-006229-7yoilsho	5524	15	for	for	IN
cord-006229-7yoilsho	5524	16	72	72	CD
cord-006229-7yoilsho	5524	17	h.	h.	NN
cord-006229-7yoilsho	5525	1	For	for	IN
cord-006229-7yoilsho	5525	2	standard	standard	JJ
cord-006229-7yoilsho	5525	3	MN	MN	NNP
cord-006229-7yoilsho	5525	4	scoring	scoring	NN
cord-006229-7yoilsho	5525	5	,	,	,
cord-006229-7yoilsho	5525	6	cells	cell	NNS
cord-006229-7yoilsho	5525	7	were	be	VBD
cord-006229-7yoilsho	5525	8	harvested	harvest	VBN
cord-006229-7yoilsho	5525	9	,	,	,
cord-006229-7yoilsho	5525	10	subjected	subject	VBN
cord-006229-7yoilsho	5525	11	to	to	IN
cord-006229-7yoilsho	5525	12	hypotonic	hypotonic	JJ
cord-006229-7yoilsho	5525	13	treatment	treatment	NN
cord-006229-7yoilsho	5525	14	,	,	,
cord-006229-7yoilsho	5525	15	fixed	fix	VBN
cord-006229-7yoilsho	5525	16	with	with	IN
cord-006229-7yoilsho	5525	17	methanol	methanol	NN
cord-006229-7yoilsho	5525	18	/	/	SYM
cord-006229-7yoilsho	5525	19	acetic	acetic	NN
cord-006229-7yoilsho	5525	20	acid	acid	NN
cord-006229-7yoilsho	5525	21	,	,	,
cord-006229-7yoilsho	5525	22	placed	place	VBN
cord-006229-7yoilsho	5525	23	on	on	IN
cord-006229-7yoilsho	5525	24	glass	glass	NN
cord-006229-7yoilsho	5525	25	slides	slide	NNS
cord-006229-7yoilsho	5525	26	,	,	,
cord-006229-7yoilsho	5525	27	stained	stain	VBN
cord-006229-7yoilsho	5525	28	with	with	IN
cord-006229-7yoilsho	5525	29	acridine	acridine	JJ
cord-006229-7yoilsho	5525	30	orange	orange	NN
cord-006229-7yoilsho	5525	31	and	and	CC
cord-006229-7yoilsho	5525	32	observed	observe	VBN
cord-006229-7yoilsho	5525	33	by	by	IN
cord-006229-7yoilsho	5525	34	fluorescence	fluorescence	NN
cord-006229-7yoilsho	5525	35	microscopy	microscopy	NNS
cord-006229-7yoilsho	5525	36	.	.	.
cord-006229-7yoilsho	5526	1	For	for	IN
cord-006229-7yoilsho	5526	2	the	the	DT
cord-006229-7yoilsho	5526	3	flow	flow	NN
cord-006229-7yoilsho	5526	4	cytometric	cytometric	NN
cord-006229-7yoilsho	5526	5	method	method	NN
cord-006229-7yoilsho	5526	6	,	,	,
cord-006229-7yoilsho	5526	7	harvested	harvest	VBN
cord-006229-7yoilsho	5526	8	cells	cell	NNS
cord-006229-7yoilsho	5526	9	were	be	VBD
cord-006229-7yoilsho	5526	10	stained	stain	VBN
cord-006229-7yoilsho	5526	11	in	in	IN
cord-006229-7yoilsho	5526	12	two	two	CD
cord-006229-7yoilsho	5526	13	sequential	sequential	JJ
cord-006229-7yoilsho	5526	14	steps	step	NNS
cord-006229-7yoilsho	5526	15	.	.	.
cord-006229-7yoilsho	5527	1	Intact	intact	JJ
cord-006229-7yoilsho	5527	2	cells	cell	NNS
cord-006229-7yoilsho	5527	3	were	be	VBD
cord-006229-7yoilsho	5527	4	subjected	subject	VBN
cord-006229-7yoilsho	5527	5	to	to	IN
cord-006229-7yoilsho	5527	6	ethidium	ethidium	NN
cord-006229-7yoilsho	5527	7	monazide	monazide	NN
cord-006229-7yoilsho	5527	8	bromide	bromide	NN
cord-006229-7yoilsho	5527	9	followed	follow	VBN
cord-006229-7yoilsho	5527	10	by	by	IN
cord-006229-7yoilsho	5527	11	photoactivation	photoactivation	NN
cord-006229-7yoilsho	5527	12	(	(	-LRB-
cord-006229-7yoilsho	5527	13	75	75	CD
cord-006229-7yoilsho	5527	14	W	W	NNP
cord-006229-7yoilsho	5527	15	,	,	,
cord-006229-7yoilsho	5527	16	20	20	CD
cord-006229-7yoilsho	5527	17	min	min	NN
cord-006229-7yoilsho	5527	18	)	)	-RRB-
cord-006229-7yoilsho	5527	19	to	to	TO
cord-006229-7yoilsho	5527	20	label	label	VB
cord-006229-7yoilsho	5527	21	dead	dead	JJ
cord-006229-7yoilsho	5527	22	or	or	CC
cord-006229-7yoilsho	5527	23	dying	die	VBG
cord-006229-7yoilsho	5527	24	cells	cell	NNS
cord-006229-7yoilsho	5527	25	.	.	.
cord-006229-7yoilsho	5528	1	Then	then	RB
cord-006229-7yoilsho	5528	2	,	,	,
cord-006229-7yoilsho	5528	3	cells	cell	NNS
cord-006229-7yoilsho	5528	4	were	be	VBD
cord-006229-7yoilsho	5528	5	lysed	lyse	VBN
cord-006229-7yoilsho	5528	6	and	and	CC
cord-006229-7yoilsho	5528	7	stained	stain	VBN
cord-006229-7yoilsho	5528	8	with	with	IN
cord-006229-7yoilsho	5528	9	SYTOX	SYTOX	NNP
cord-006229-7yoilsho	5528	10	green	green	NNP
cord-006229-7yoilsho	5528	11	for	for	IN
cord-006229-7yoilsho	5528	12	a	a	DT
cord-006229-7yoilsho	5528	13	pan	pan	JJ
cord-006229-7yoilsho	5528	14	-	-	JJ
cord-006229-7yoilsho	5528	15	DNA	dna	NN
cord-006229-7yoilsho	5528	16	labelling	labelling	NN
cord-006229-7yoilsho	5528	17	and	and	CC
cord-006229-7yoilsho	5528	18	analyzed	analyze	VBD
cord-006229-7yoilsho	5528	19	on	on	IN
cord-006229-7yoilsho	5528	20	a	a	DT
cord-006229-7yoilsho	5528	21	flow	flow	NN
cord-006229-7yoilsho	5528	22	cytometer	cytometer	NN
cord-006229-7yoilsho	5528	23	.	.	.
cord-006229-7yoilsho	5529	1	Both	both	DT
cord-006229-7yoilsho	5529	2	,	,	,
cord-006229-7yoilsho	5529	3	chemically	chemically	RB
cord-006229-7yoilsho	5529	4	-	-	:
cord-006229-7yoilsho	5529	5	and	and	CC
cord-006229-7yoilsho	5529	6	radiation	radiation	NN
cord-006229-7yoilsho	5529	7	-	-	HYPH
cord-006229-7yoilsho	5529	8	induced	induce	VBN
cord-006229-7yoilsho	5529	9	treatment	treatment	NN
cord-006229-7yoilsho	5529	10	led	lead	VBD
cord-006229-7yoilsho	5529	11	to	to	IN
cord-006229-7yoilsho	5529	12	a	a	DT
cord-006229-7yoilsho	5529	13	dose	dose	NN
cord-006229-7yoilsho	5529	14	-	-	HYPH
cord-006229-7yoilsho	5529	15	dependent	dependent	JJ
cord-006229-7yoilsho	5529	16	induction	induction	NN
cord-006229-7yoilsho	5529	17	of	of	IN
cord-006229-7yoilsho	5529	18	MN	MN	NNP
cord-006229-7yoilsho	5529	19	when	when	WRB
cord-006229-7yoilsho	5529	20	evaluated	evaluate	VBN
cord-006229-7yoilsho	5529	21	by	by	IN
cord-006229-7yoilsho	5529	22	fluorescence	fluorescence	NN
cord-006229-7yoilsho	5529	23	microscopy	microscopy	NN
cord-006229-7yoilsho	5529	24	.	.	.
cord-006229-7yoilsho	5530	1	When	when	WRB
cord-006229-7yoilsho	5530	2	the	the	DT
cord-006229-7yoilsho	5530	3	flow	flow	NN
cord-006229-7yoilsho	5530	4	cytometry	cytometry	NN
cord-006229-7yoilsho	5530	5	-	-	HYPH
cord-006229-7yoilsho	5530	6	based	base	VBN
cord-006229-7yoilsho	5530	7	method	method	NN
cord-006229-7yoilsho	5530	8	was	be	VBD
cord-006229-7yoilsho	5530	9	applied	apply	VBN
cord-006229-7yoilsho	5530	10	,	,	,
cord-006229-7yoilsho	5530	11	clearly	clearly	RB
cord-006229-7yoilsho	5530	12	positive	positive	JJ
cord-006229-7yoilsho	5530	13	results	result	NNS
cord-006229-7yoilsho	5530	14	including	include	VBG
cord-006229-7yoilsho	5530	15	a	a	DT
cord-006229-7yoilsho	5530	16	dose	dose	NN
cord-006229-7yoilsho	5530	17	-	-	HYPH
cord-006229-7yoilsho	5530	18	dependent	dependent	JJ
cord-006229-7yoilsho	5530	19	induction	induction	NN
cord-006229-7yoilsho	5530	20	of	of	IN
cord-006229-7yoilsho	5530	21	MN	MN	NNP
cord-006229-7yoilsho	5530	22	,	,	,
cord-006229-7yoilsho	5530	23	however	however	RB
cord-006229-7yoilsho	5530	24	,	,	,
cord-006229-7yoilsho	5530	25	were	be	VBD
cord-006229-7yoilsho	5530	26	obtained	obtain	VBN
cord-006229-7yoilsho	5530	27	only	only	RB
cord-006229-7yoilsho	5530	28	for	for	IN
cord-006229-7yoilsho	5530	29	3	3	CD
cord-006229-7yoilsho	5530	30	out	out	IN
cord-006229-7yoilsho	5530	31	of	of	IN
cord-006229-7yoilsho	5530	32	the	the	DT
cord-006229-7yoilsho	5530	33	5	5	CD
cord-006229-7yoilsho	5530	34	treatments	treatment	NNS
cord-006229-7yoilsho	5530	35	(	(	-LRB-
cord-006229-7yoilsho	5530	36	vincristine	vincristine	NN
cord-006229-7yoilsho	5530	37	,	,	,
cord-006229-7yoilsho	5530	38	colcemid	colcemid	NNP
cord-006229-7yoilsho	5530	39	and	and	CC
cord-006229-7yoilsho	5530	40	X	X	NNS
cord-006229-7yoilsho	5530	41	-	-	NNS
cord-006229-7yoilsho	5530	42	rays	ray	NNS
cord-006229-7yoilsho	5530	43	)	)	-RRB-
cord-006229-7yoilsho	5530	44	;	;	:
cord-006229-7yoilsho	5530	45	whereas	whereas	RB
cord-006229-7yoilsho	5530	46	,	,	,
cord-006229-7yoilsho	5530	47	treatment	treatment	NN
cord-006229-7yoilsho	5530	48	with	with	IN
cord-006229-7yoilsho	5530	49	MMS	MMS	NNP
cord-006229-7yoilsho	5530	50	and	and	CC
cord-006229-7yoilsho	5530	51	B[a]P	B[a]P	NNP
cord-006229-7yoilsho	5530	52	led	lead	VBD
cord-006229-7yoilsho	5530	53	to	to	IN
cord-006229-7yoilsho	5530	54	only	only	JJ
cord-006229-7yoilsho	5530	55	minor	minor	JJ
cord-006229-7yoilsho	5530	56	increases	increase	NNS
cord-006229-7yoilsho	5530	57	in	in	IN
cord-006229-7yoilsho	5530	58	relative	relative	JJ
cord-006229-7yoilsho	5530	59	MN	MN	NNP
cord-006229-7yoilsho	5530	60	frequencies	frequency	NNS
cord-006229-7yoilsho	5530	61	(	(	-LRB-
cord-006229-7yoilsho	5530	62	≤2-fold	≤2-fold	CD
cord-006229-7yoilsho	5530	63	)	)	-RRB-
cord-006229-7yoilsho	5530	64	,	,	,
cord-006229-7yoilsho	5530	65	even	even	RB
cord-006229-7yoilsho	5530	66	at	at	IN
cord-006229-7yoilsho	5530	67	the	the	DT
cord-006229-7yoilsho	5530	68	maximum	maximum	JJ
cord-006229-7yoilsho	5530	69	concentrations	concentration	NNS
cord-006229-7yoilsho	5530	70	.	.	.
cord-006229-7yoilsho	5531	1	In	in	IN
cord-006229-7yoilsho	5531	2	summary	summary	NN
cord-006229-7yoilsho	5531	3	,	,	,
cord-006229-7yoilsho	5531	4	flow	flow	NN
cord-006229-7yoilsho	5531	5	cytometry	cytometry	NN
cord-006229-7yoilsho	5531	6	-	-	HYPH
cord-006229-7yoilsho	5531	7	based	base	VBN
cord-006229-7yoilsho	5531	8	MN	MN	NNP
cord-006229-7yoilsho	5531	9	scoring	scoring	NN
cord-006229-7yoilsho	5531	10	has	have	VBZ
cord-006229-7yoilsho	5531	11	been	be	VBN
cord-006229-7yoilsho	5531	12	successfully	successfully	RB
cord-006229-7yoilsho	5531	13	applied	apply	VBN
cord-006229-7yoilsho	5531	14	in	in	IN
cord-006229-7yoilsho	5531	15	RT4	rt4	NN
cord-006229-7yoilsho	5531	16	cells	cell	NNS
cord-006229-7yoilsho	5531	17	.	.	.
cord-006229-7yoilsho	5532	1	However	however	RB
cord-006229-7yoilsho	5532	2	,	,	,
cord-006229-7yoilsho	5532	3	our	-PRON-	PRP$
cord-006229-7yoilsho	5532	4	initial	initial	JJ
cord-006229-7yoilsho	5532	5	results	result	NNS
cord-006229-7yoilsho	5532	6	suggest	suggest	VBP
cord-006229-7yoilsho	5532	7	that	that	DT
cord-006229-7yoilsho	5532	8	flow	flow	NN
cord-006229-7yoilsho	5532	9	cytometry	cytometry	NN
cord-006229-7yoilsho	5532	10	-	-	HYPH
cord-006229-7yoilsho	5532	11	based	base	VBN
cord-006229-7yoilsho	5532	12	MN	MN	NNP
cord-006229-7yoilsho	5532	13	scoring	scoring	NN
cord-006229-7yoilsho	5532	14	is	be	VBZ
cord-006229-7yoilsho	5532	15	less	less	RBR
cord-006229-7yoilsho	5532	16	sensitive	sensitive	JJ
cord-006229-7yoilsho	5532	17	than	than	IN
cord-006229-7yoilsho	5532	18	microscopic	microscopic	JJ
cord-006229-7yoilsho	5532	19	scoring	scoring	NN
cord-006229-7yoilsho	5532	20	when	when	WRB
cord-006229-7yoilsho	5532	21	RT4	rt4	NN
cord-006229-7yoilsho	5532	22	cells	cell	NNS
cord-006229-7yoilsho	5532	23	are	be	VBP
cord-006229-7yoilsho	5532	24	used	use	VBN
cord-006229-7yoilsho	5532	25	.	.	.
cord-006229-7yoilsho	5533	1	So	so	RB
cord-006229-7yoilsho	5533	2	far	far	RB
cord-006229-7yoilsho	5533	3	,	,	,
cord-006229-7yoilsho	5533	4	only	only	RB
cord-006229-7yoilsho	5533	5	few	few	JJ
cord-006229-7yoilsho	5533	6	adherently	adherently	RB
cord-006229-7yoilsho	5533	7	growing	grow	VBG
cord-006229-7yoilsho	5533	8	cell	cell	NN
cord-006229-7yoilsho	5533	9	lines	line	NNS
cord-006229-7yoilsho	5533	10	have	have	VBP
cord-006229-7yoilsho	5533	11	been	be	VBN
cord-006229-7yoilsho	5533	12	applied	apply	VBN
cord-006229-7yoilsho	5533	13	to	to	TO
cord-006229-7yoilsho	5533	14	flow	flow	VB
cord-006229-7yoilsho	5533	15	cytometry	cytometry	NN
cord-006229-7yoilsho	5533	16	-	-	HYPH
cord-006229-7yoilsho	5533	17	based	base	VBN
cord-006229-7yoilsho	5533	18	MN	MN	NNP
cord-006229-7yoilsho	5533	19	scoring	scoring	NN
cord-006229-7yoilsho	5533	20	.	.	.
cord-006229-7yoilsho	5534	1	Further	further	JJ
cord-006229-7yoilsho	5534	2	substances	substance	NNS
cord-006229-7yoilsho	5534	3	(	(	-LRB-
cord-006229-7yoilsho	5534	4	positive	positive	JJ
cord-006229-7yoilsho	5534	5	and	and	CC
cord-006229-7yoilsho	5534	6	negative	negative	JJ
cord-006229-7yoilsho	5534	7	controls	control	NNS
cord-006229-7yoilsho	5534	8	)	)	-RRB-
cord-006229-7yoilsho	5534	9	and	and	CC
cord-006229-7yoilsho	5534	10	possibly	possibly	RB
cord-006229-7yoilsho	5534	11	other	other	JJ
cord-006229-7yoilsho	5534	12	adherent	adherent	JJ
cord-006229-7yoilsho	5534	13	cell	cell	NN
cord-006229-7yoilsho	5534	14	lines	line	NNS
cord-006229-7yoilsho	5534	15	need	need	VBP
cord-006229-7yoilsho	5534	16	to	to	TO
cord-006229-7yoilsho	5534	17	be	be	VB
cord-006229-7yoilsho	5534	18	tested	test	VBN
cord-006229-7yoilsho	5534	19	to	to	TO
cord-006229-7yoilsho	5534	20	expand	expand	VB
cord-006229-7yoilsho	5534	21	our	-PRON-	PRP$
cord-006229-7yoilsho	5534	22	knowledge	knowledge	NN
cord-006229-7yoilsho	5534	23	on	on	IN
cord-006229-7yoilsho	5534	24	the	the	DT
cord-006229-7yoilsho	5534	25	effectiveness	effectiveness	NN
cord-006229-7yoilsho	5534	26	of	of	IN
cord-006229-7yoilsho	5534	27	automated	automate	VBN
cord-006229-7yoilsho	5534	28	MN	MN	NNP
cord-006229-7yoilsho	5534	29	scoring	scoring	NN
cord-006229-7yoilsho	5534	30	in	in	IN
cord-006229-7yoilsho	5534	31	vitro	vitro	FW
cord-006229-7yoilsho	5534	32	and	and	CC
cord-006229-7yoilsho	5534	33	compared	compare	VBN
cord-006229-7yoilsho	5534	34	to	to	IN
cord-006229-7yoilsho	5534	35	traditional	traditional	JJ
cord-006229-7yoilsho	5534	36	approaches	approach	NNS
cord-006229-7yoilsho	5534	37	.	.	.
cord-006229-7yoilsho	5535	1	Background	background	NN
cord-006229-7yoilsho	5535	2	:	:	:
cord-006229-7yoilsho	5536	1	The	the	DT
cord-006229-7yoilsho	5536	2	platinating	platinating	NN
cord-006229-7yoilsho	5536	3	agent	agent	NN
cord-006229-7yoilsho	5536	4	cisplatin	cisplatin	NN
cord-006229-7yoilsho	5536	5	is	be	VBZ
cord-006229-7yoilsho	5536	6	commonly	commonly	RB
cord-006229-7yoilsho	5536	7	used	use	VBN
cord-006229-7yoilsho	5536	8	in	in	IN
cord-006229-7yoilsho	5536	9	the	the	DT
cord-006229-7yoilsho	5536	10	therapy	therapy	NN
cord-006229-7yoilsho	5536	11	of	of	IN
cord-006229-7yoilsho	5536	12	various	various	JJ
cord-006229-7yoilsho	5536	13	types	type	NNS
cord-006229-7yoilsho	5536	14	of	of	IN
cord-006229-7yoilsho	5536	15	solid	solid	JJ
cord-006229-7yoilsho	5536	16	tumors	tumor	NNS
cord-006229-7yoilsho	5536	17	,	,	,
cord-006229-7yoilsho	5536	18	especially	especially	RB
cord-006229-7yoilsho	5536	19	urogenital	urogenital	JJ
cord-006229-7yoilsho	5536	20	cancers	cancer	NNS
cord-006229-7yoilsho	5536	21	.	.	.
cord-006229-7yoilsho	5537	1	Its	-PRON-	PRP$
cord-006229-7yoilsho	5537	2	anticancer	anticancer	JJ
cord-006229-7yoilsho	5537	3	efficacy	efficacy	NN
cord-006229-7yoilsho	5537	4	largely	largely	RB
cord-006229-7yoilsho	5537	5	depends	depend	VBZ
cord-006229-7yoilsho	5537	6	on	on	IN
cord-006229-7yoilsho	5537	7	the	the	DT
cord-006229-7yoilsho	5537	8	formation	formation	NN
cord-006229-7yoilsho	5537	9	of	of	IN
cord-006229-7yoilsho	5537	10	bivalent	bivalent	JJ
cord-006229-7yoilsho	5537	11	DNA	dna	NN
cord-006229-7yoilsho	5537	12	intrastrand	intrastrand	NN
cord-006229-7yoilsho	5537	13	crosslinks	crosslink	NNS
cord-006229-7yoilsho	5537	14	,	,	,
cord-006229-7yoilsho	5537	15	which	which	WDT
cord-006229-7yoilsho	5537	16	impair	impair	VBP
cord-006229-7yoilsho	5537	17	DNA	dna	NN
cord-006229-7yoilsho	5537	18	replication	replication	NN
cord-006229-7yoilsho	5537	19	and	and	CC
cord-006229-7yoilsho	5537	20	transcription	transcription	NN
cord-006229-7yoilsho	5537	21	.	.	.
cord-006229-7yoilsho	5538	1	These	these	DT
cord-006229-7yoilsho	5538	2	crosslinks	crosslink	NNS
cord-006229-7yoilsho	5538	3	stimulate	stimulate	VBP
cord-006229-7yoilsho	5538	4	mechanisms	mechanism	NNS
cord-006229-7yoilsho	5538	5	of	of	IN
cord-006229-7yoilsho	5538	6	the	the	DT
cord-006229-7yoilsho	5538	7	DNA	dna	NN
cord-006229-7yoilsho	5538	8	damage	damage	NN
cord-006229-7yoilsho	5538	9	response	response	NN
cord-006229-7yoilsho	5538	10	(	(	-LRB-
cord-006229-7yoilsho	5538	11	DDR	DDR	NNP
cord-006229-7yoilsho	5538	12	)	)	-RRB-
cord-006229-7yoilsho	5538	13	,	,	,
cord-006229-7yoilsho	5538	14	thereby	thereby	RB
cord-006229-7yoilsho	5538	15	triggering	trigger	VBG
cord-006229-7yoilsho	5538	16	checkpoint	checkpoint	NN
cord-006229-7yoilsho	5538	17	activation	activation	NN
cord-006229-7yoilsho	5538	18	,	,	,
cord-006229-7yoilsho	5538	19	gene	gene	NN
cord-006229-7yoilsho	5538	20	expression	expression	NN
cord-006229-7yoilsho	5538	21	and	and	CC
cord-006229-7yoilsho	5538	22	cell	cell	NN
cord-006229-7yoilsho	5538	23	death	death	NN
cord-006229-7yoilsho	5538	24	.	.	.
cord-006229-7yoilsho	5539	1	The	the	DT
cord-006229-7yoilsho	5539	2	clinically	clinically	RB
cord-006229-7yoilsho	5539	3	most	most	RBS
cord-006229-7yoilsho	5539	4	relevant	relevant	JJ
cord-006229-7yoilsho	5539	5	adverse	adverse	JJ
cord-006229-7yoilsho	5539	6	effect	effect	NN
cord-006229-7yoilsho	5539	7	associated	associate	VBN
cord-006229-7yoilsho	5539	8	with	with	IN
cord-006229-7yoilsho	5539	9	cisplatin	cisplatin	NN
cord-006229-7yoilsho	5539	10	treatment	treatment	NN
cord-006229-7yoilsho	5539	11	is	be	VBZ
cord-006229-7yoilsho	5539	12	nephrotoxicity	nephrotoxicity	NN
cord-006229-7yoilsho	5539	13	,	,	,
cord-006229-7yoilsho	5539	14	which	which	WDT
cord-006229-7yoilsho	5539	15	mainly	mainly	RB
cord-006229-7yoilsho	5539	16	results	result	VBZ
cord-006229-7yoilsho	5539	17	from	from	IN
cord-006229-7yoilsho	5539	18	damaged	damage	VBN
cord-006229-7yoilsho	5539	19	tubular	tubular	JJ
cord-006229-7yoilsho	5539	20	cells	cell	NNS
cord-006229-7yoilsho	5539	21	.	.	.
cord-006229-7yoilsho	5540	1	Here	here	RB
cord-006229-7yoilsho	5540	2	,	,	,
cord-006229-7yoilsho	5540	3	we	-PRON-	PRP
cord-006229-7yoilsho	5540	4	analyzed	analyze	VBD
cord-006229-7yoilsho	5540	5	the	the	DT
cord-006229-7yoilsho	5540	6	influence	influence	NN
cord-006229-7yoilsho	5540	7	of	of	IN
cord-006229-7yoilsho	5540	8	the	the	DT
cord-006229-7yoilsho	5540	9	HMG	HMG	NNP
cord-006229-7yoilsho	5540	10	-	-	HYPH
cord-006229-7yoilsho	5540	11	CoA	coa	NN
cord-006229-7yoilsho	5540	12	-	-	HYPH
cord-006229-7yoilsho	5540	13	reductase	reductase	NN
cord-006229-7yoilsho	5540	14	inhibitor	inhibitor	NN
cord-006229-7yoilsho	5540	15	lovastatin	lovastatin	NN
cord-006229-7yoilsho	5540	16	on	on	IN
cord-006229-7yoilsho	5540	17	the	the	DT
cord-006229-7yoilsho	5540	18	cisplatin	cisplatin	NN
cord-006229-7yoilsho	5540	19	-	-	HYPH
cord-006229-7yoilsho	5540	20	induced	induce	VBN
cord-006229-7yoilsho	5540	21	geno	geno	NNP
cord-006229-7yoilsho	5540	22	-	-	:
cord-006229-7yoilsho	5540	23	and	and	CC
cord-006229-7yoilsho	5540	24	cytotoxicity	cytotoxicity	NN
cord-006229-7yoilsho	5540	25	in	in	IN
cord-006229-7yoilsho	5540	26	the	the	DT
cord-006229-7yoilsho	5540	27	rat	rat	NN
cord-006229-7yoilsho	5540	28	renal	renal	JJ
cord-006229-7yoilsho	5540	29	proximal	proximal	VBD
cord-006229-7yoilsho	5540	30	tubular	tubular	JJ
cord-006229-7yoilsho	5540	31	epithelial	epithelial	JJ
cord-006229-7yoilsho	5540	32	cell	cell	NN
cord-006229-7yoilsho	5540	33	line	line	NN
cord-006229-7yoilsho	5540	34	NRK-52E.	NRK-52E.	NNP
cord-006229-7yoilsho	5540	35	Methods	method	NNS
cord-006229-7yoilsho	5540	36	:	:	:
cord-006229-7yoilsho	5540	37	Cell	cell	NN
cord-006229-7yoilsho	5540	38	viability	viability	NN
cord-006229-7yoilsho	5540	39	was	be	VBD
cord-006229-7yoilsho	5540	40	determined	determine	VBN
cord-006229-7yoilsho	5540	41	by	by	IN
cord-006229-7yoilsho	5540	42	using	use	VBG
cord-006229-7yoilsho	5540	43	the	the	DT
cord-006229-7yoilsho	5540	44	Alamar	Alamar	NNP
cord-006229-7yoilsho	5540	45	Blue	Blue	NNP
cord-006229-7yoilsho	5540	46	assay	assay	NN
cord-006229-7yoilsho	5540	47	,	,	,
cord-006229-7yoilsho	5540	48	as	as	RB
cord-006229-7yoilsho	5540	49	well	well	RB
cord-006229-7yoilsho	5540	50	as	as	IN
cord-006229-7yoilsho	5540	51	by	by	IN
cord-006229-7yoilsho	5540	52	electrical	electrical	JJ
cord-006229-7yoilsho	5540	53	impedance	impedance	NN
cord-006229-7yoilsho	5540	54	measurements	measurement	NNS
cord-006229-7yoilsho	5540	55	via	via	IN
cord-006229-7yoilsho	5540	56	the	the	DT
cord-006229-7yoilsho	5540	57	iCELLigence	icelligence	NN
cord-006229-7yoilsho	5540	58	system	system	NN
cord-006229-7yoilsho	5540	59	.	.	.
cord-006229-7yoilsho	5541	1	Alterations	alteration	NNS
cord-006229-7yoilsho	5541	2	in	in	IN
cord-006229-7yoilsho	5541	3	cell	cell	NN
cord-006229-7yoilsho	5541	4	cycle	cycle	NN
cord-006229-7yoilsho	5541	5	progression	progression	NN
cord-006229-7yoilsho	5541	6	were	be	VBD
cord-006229-7yoilsho	5541	7	assayed	assay	VBN
cord-006229-7yoilsho	5541	8	by	by	IN
cord-006229-7yoilsho	5541	9	flow	flow	NN
cord-006229-7yoilsho	5541	10	cytometric	cytometric	NNP
cord-006229-7yoilsho	5541	11	analysis	analysis	NN
cord-006229-7yoilsho	5541	12	.	.	.
cord-006229-7yoilsho	5542	1	The	the	DT
cord-006229-7yoilsho	5542	2	formation	formation	NN
cord-006229-7yoilsho	5542	3	of	of	IN
cord-006229-7yoilsho	5542	4	Pt-(GpG	Pt-(GpG	NNP
cord-006229-7yoilsho	5542	5	)	)	-RRB-
cord-006229-7yoilsho	5543	1	intrastrand	intrastrand	NNP
cord-006229-7yoilsho	5543	2	crosslinks	crosslink	NNS
cord-006229-7yoilsho	5543	3	was	be	VBD
cord-006229-7yoilsho	5543	4	determined	determine	VBN
cord-006229-7yoilsho	5543	5	via	via	IN
cord-006229-7yoilsho	5543	6	Southwestern	Southwestern	NNP
cord-006229-7yoilsho	5543	7	blot	blot	NN
cord-006229-7yoilsho	5543	8	.	.	.
cord-006229-7yoilsho	5544	1	The	the	DT
cord-006229-7yoilsho	5544	2	amount	amount	NN
cord-006229-7yoilsho	5544	3	of	of	IN
cord-006229-7yoilsho	5544	4	DNA	dna	NN
cord-006229-7yoilsho	5544	5	double	double	JJ
cord-006229-7yoilsho	5544	6	-	-	HYPH
cord-006229-7yoilsho	5544	7	strand	strand	NN
cord-006229-7yoilsho	5544	8	breaks	break	NNS
cord-006229-7yoilsho	5544	9	(	(	-LRB-
cord-006229-7yoilsho	5544	10	DSBs	dsb	NNS
cord-006229-7yoilsho	5544	11	)	)	-RRB-
cord-006229-7yoilsho	5544	12	was	be	VBD
cord-006229-7yoilsho	5544	13	quantified	quantify	VBN
cord-006229-7yoilsho	5544	14	by	by	IN
cord-006229-7yoilsho	5544	15	measuring	measure	VBG
cord-006229-7yoilsho	5544	16	the	the	DT
cord-006229-7yoilsho	5544	17	level	level	NN
cord-006229-7yoilsho	5544	18	of	of	IN
cord-006229-7yoilsho	5544	19	S139	S139	NNP
cord-006229-7yoilsho	5544	20	phosphorylated	phosphorylate	VBN
cord-006229-7yoilsho	5544	21	H2AX	H2AX	NNP
cord-006229-7yoilsho	5544	22	(	(	-LRB-
cord-006229-7yoilsho	5544	23	γH2AX	γH2AX	NNP
cord-006229-7yoilsho	5544	24	)	)	-RRB-
cord-006229-7yoilsho	5544	25	via	via	IN
cord-006229-7yoilsho	5544	26	immunocytochemistry	immunocytochemistry	NNP
cord-006229-7yoilsho	5544	27	as	as	RB
cord-006229-7yoilsho	5544	28	well	well	RB
cord-006229-7yoilsho	5544	29	as	as	IN
cord-006229-7yoilsho	5544	30	by	by	IN
cord-006229-7yoilsho	5544	31	Western	western	JJ
cord-006229-7yoilsho	5544	32	blot	blot	NN
cord-006229-7yoilsho	5544	33	.	.	.
cord-006229-7yoilsho	5545	1	Additionally	additionally	RB
cord-006229-7yoilsho	5545	2	,	,	,
cord-006229-7yoilsho	5545	3	neutral	neutral	JJ
cord-006229-7yoilsho	5545	4	and	and	CC
cord-006229-7yoilsho	5545	5	alkaline	alkaline	JJ
cord-006229-7yoilsho	5545	6	Comet	Comet	NNP
cord-006229-7yoilsho	5545	7	assays	assay	NNS
cord-006229-7yoilsho	5545	8	were	be	VBD
cord-006229-7yoilsho	5545	9	performed	perform	VBN
cord-006229-7yoilsho	5545	10	to	to	TO
cord-006229-7yoilsho	5545	11	determine	determine	VB
cord-006229-7yoilsho	5545	12	the	the	DT
cord-006229-7yoilsho	5545	13	amount	amount	NN
cord-006229-7yoilsho	5545	14	of	of	IN
cord-006229-7yoilsho	5545	15	DNA	dna	NN
cord-006229-7yoilsho	5545	16	single	single	JJ
cord-006229-7yoilsho	5545	17	-	-	HYPH
cord-006229-7yoilsho	5545	18	and	and	CC
cord-006229-7yoilsho	5545	19	DNA	dna	NN
cord-006229-7yoilsho	5545	20	double	double	JJ
cord-006229-7yoilsho	5545	21	-	-	HYPH
cord-006229-7yoilsho	5545	22	strand	strand	NN
cord-006229-7yoilsho	5545	23	breaks	break	NNS
cord-006229-7yoilsho	5545	24	.	.	.
cord-006229-7yoilsho	5546	1	Mechanisms	mechanism	NNS
cord-006229-7yoilsho	5546	2	of	of	IN
cord-006229-7yoilsho	5546	3	the	the	DT
cord-006229-7yoilsho	5546	4	DDR	DDR	NNP
cord-006229-7yoilsho	5546	5	were	be	VBD
cord-006229-7yoilsho	5546	6	analyzed	analyze	VBN
cord-006229-7yoilsho	5546	7	by	by	IN
cord-006229-7yoilsho	5546	8	Western	western	JJ
cord-006229-7yoilsho	5546	9	blot	blot	NN
cord-006229-7yoilsho	5546	10	as	as	RB
cord-006229-7yoilsho	5546	11	well	well	RB
cord-006229-7yoilsho	5546	12	as	as	IN
cord-006229-7yoilsho	5546	13	by	by	IN
cord-006229-7yoilsho	5546	14	quantitative	quantitative	JJ
cord-006229-7yoilsho	5546	15	real	real	JJ
cord-006229-7yoilsho	5546	16	-	-	HYPH
cord-006229-7yoilsho	5546	17	time	time	NN
cord-006229-7yoilsho	5546	18	PCR	PCR	NNP
cord-006229-7yoilsho	5546	19	.	.	.
cord-006229-7yoilsho	5547	1	Results	result	NNS
cord-006229-7yoilsho	5547	2	:	:	:
cord-006229-7yoilsho	5548	1	The	the	DT
cord-006229-7yoilsho	5548	2	data	datum	NNS
cord-006229-7yoilsho	5548	3	show	show	VBP
cord-006229-7yoilsho	5548	4	that	that	IN
cord-006229-7yoilsho	5548	5	pretreatment	pretreatment	NN
cord-006229-7yoilsho	5548	6	of	of	IN
cord-006229-7yoilsho	5548	7	NRK-52E	NRK-52E	NNP
cord-006229-7yoilsho	5548	8	cells	cell	NNS
cord-006229-7yoilsho	5548	9	with	with	IN
cord-006229-7yoilsho	5548	10	a	a	DT
cord-006229-7yoilsho	5548	11	subtoxic	subtoxic	JJ
cord-006229-7yoilsho	5548	12	dose	dose	NN
cord-006229-7yoilsho	5548	13	of	of	IN
cord-006229-7yoilsho	5548	14	lovastatin	lovastatin	NN
cord-006229-7yoilsho	5548	15	reduced	reduce	VBD
cord-006229-7yoilsho	5548	16	the	the	DT
cord-006229-7yoilsho	5548	17	cytotoxicity	cytotoxicity	NN
cord-006229-7yoilsho	5548	18	evoked	evoke	VBN
cord-006229-7yoilsho	5548	19	by	by	IN
cord-006229-7yoilsho	5548	20	high	high	JJ
cord-006229-7yoilsho	5548	21	doses	dose	NNS
cord-006229-7yoilsho	5548	22	of	of	IN
cord-006229-7yoilsho	5548	23	cisplatin	cisplatin	NN
cord-006229-7yoilsho	5548	24	by	by	IN
cord-006229-7yoilsho	5548	25	protection	protection	NN
cord-006229-7yoilsho	5548	26	from	from	IN
cord-006229-7yoilsho	5548	27	cisplatin	cisplatin	NN
cord-006229-7yoilsho	5548	28	-	-	HYPH
cord-006229-7yoilsho	5548	29	stimulated	stimulate	VBN
cord-006229-7yoilsho	5548	30	apoptotic	apoptotic	JJ
cord-006229-7yoilsho	5548	31	cell	cell	NN
cord-006229-7yoilsho	5548	32	death	death	NN
cord-006229-7yoilsho	5548	33	.	.	.
cord-006229-7yoilsho	5549	1	Moreover	moreover	RB
cord-006229-7yoilsho	5549	2	,	,	,
cord-006229-7yoilsho	5549	3	Lovastatin	Lovastatin	NNP
cord-006229-7yoilsho	5549	4	had	have	VBD
cord-006229-7yoilsho	5549	5	extensive	extensive	JJ
cord-006229-7yoilsho	5549	6	inhibitory	inhibitory	JJ
cord-006229-7yoilsho	5549	7	effects	effect	NNS
cord-006229-7yoilsho	5549	8	on	on	IN
cord-006229-7yoilsho	5549	9	cisplatin	cisplatin	NN
cord-006229-7yoilsho	5549	10	-	-	HYPH
cord-006229-7yoilsho	5549	11	induced	induce	VBN
cord-006229-7yoilsho	5549	12	DDR	ddr	NN
cord-006229-7yoilsho	5549	13	,	,	,
cord-006229-7yoilsho	5549	14	as	as	IN
cord-006229-7yoilsho	5549	15	reflected	reflect	VBN
cord-006229-7yoilsho	5549	16	on	on	IN
cord-006229-7yoilsho	5549	17	the	the	DT
cord-006229-7yoilsho	5549	18	level	level	NN
cord-006229-7yoilsho	5549	19	of	of	IN
cord-006229-7yoilsho	5549	20	p	p	NN
cord-006229-7yoilsho	5549	21	-	-	HYPH
cord-006229-7yoilsho	5549	22	ATM	atm	NN
cord-006229-7yoilsho	5549	23	,	,	,
cord-006229-7yoilsho	5549	24	p	p	NN
cord-006229-7yoilsho	5549	25	-	-	HYPH
cord-006229-7yoilsho	5549	26	P53	P53	NNP
cord-006229-7yoilsho	5549	27	,	,	,
cord-006229-7yoilsho	5549	28	p	p	NN
cord-006229-7yoilsho	5549	29	-	-	:
cord-006229-7yoilsho	5549	30	CHK1	CHK1	NNP
cord-006229-7yoilsho	5549	31	,	,	,
cord-006229-7yoilsho	5549	32	p	p	NN
cord-006229-7yoilsho	5549	33	-	-	:
cord-006229-7yoilsho	5549	34	CHK2	CHK2	NNP
cord-006229-7yoilsho	5549	35	and	and	CC
cord-006229-7yoilsho	5549	36	p	p	NN
cord-006229-7yoilsho	5549	37	-	-	HYPH
cord-006229-7yoilsho	5549	38	KAP1	KAP1	NNP
cord-006229-7yoilsho	5549	39	.	.	.
cord-006229-7yoilsho	5550	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	5550	2	,	,	,
cord-006229-7yoilsho	5550	3	activation	activation	NN
cord-006229-7yoilsho	5550	4	of	of	IN
cord-006229-7yoilsho	5550	5	mitogen	mitogen	NN
cord-006229-7yoilsho	5550	6	-	-	HYPH
cord-006229-7yoilsho	5550	7	activated	activate	VBN
cord-006229-7yoilsho	5550	8	kinases	kinase	NNS
cord-006229-7yoilsho	5550	9	(	(	-LRB-
cord-006229-7yoilsho	5550	10	MAPKs	MAPKs	NNP
cord-006229-7yoilsho	5550	11	)	)	-RRB-
cord-006229-7yoilsho	5550	12	was	be	VBD
cord-006229-7yoilsho	5550	13	also	also	RB
cord-006229-7yoilsho	5550	14	reduced	reduce	VBN
cord-006229-7yoilsho	5550	15	.	.	.
cord-006229-7yoilsho	5551	1	The	the	DT
cord-006229-7yoilsho	5551	2	lovastatin	lovastatin	NN
cord-006229-7yoilsho	5551	3	-	-	HYPH
cord-006229-7yoilsho	5551	4	mediated	mediate	VBN
cord-006229-7yoilsho	5551	5	mitigation	mitigation	NN
cord-006229-7yoilsho	5551	6	of	of	IN
cord-006229-7yoilsho	5551	7	cisplatin	cisplatin	NN
cord-006229-7yoilsho	5551	8	-	-	HYPH
cord-006229-7yoilsho	5551	9	induced	induce	VBN
cord-006229-7yoilsho	5551	10	DDR	DDR	NNP
cord-006229-7yoilsho	5551	11	was	be	VBD
cord-006229-7yoilsho	5551	12	independent	independent	JJ
cord-006229-7yoilsho	5551	13	of	of	IN
cord-006229-7yoilsho	5551	14	the	the	DT
cord-006229-7yoilsho	5551	15	initial	initial	JJ
cord-006229-7yoilsho	5551	16	formation	formation	NN
cord-006229-7yoilsho	5551	17	of	of	IN
cord-006229-7yoilsho	5551	18	DSBs	dsb	NNS
cord-006229-7yoilsho	5551	19	as	as	RB
cord-006229-7yoilsho	5551	20	well	well	RB
cord-006229-7yoilsho	5551	21	as	as	IN
cord-006229-7yoilsho	5551	22	of	of	IN
cord-006229-7yoilsho	5551	23	Pt-(GpG	Pt-(GpG	NNP
cord-006229-7yoilsho	5551	24	)	)	-RRB-
cord-006229-7yoilsho	5552	1	intrastrand	intrastrand	NNP
cord-006229-7yoilsho	5552	2	crosslinks	crosslink	NNS
cord-006229-7yoilsho	5552	3	.	.	.
cord-006229-7yoilsho	5553	1	Lovastatin	lovastatin	NN
cord-006229-7yoilsho	5553	2	protects	protect	VBZ
cord-006229-7yoilsho	5553	3	NRK-52E	nrk-52e	NN
cord-006229-7yoilsho	5553	4	cells	cell	NNS
cord-006229-7yoilsho	5553	5	from	from	IN
cord-006229-7yoilsho	5553	6	cisplatin	cisplatin	NN
cord-006229-7yoilsho	5553	7	-	-	HYPH
cord-006229-7yoilsho	5553	8	induced	induce	VBN
cord-006229-7yoilsho	5553	9	cytotoxicity	cytotoxicity	NN
cord-006229-7yoilsho	5553	10	by	by	IN
cord-006229-7yoilsho	5553	11	interfering	interfere	VBG
cord-006229-7yoilsho	5553	12	with	with	IN
cord-006229-7yoilsho	5553	13	proapoptotic	proapoptotic	JJ
cord-006229-7yoilsho	5553	14	mechanisms	mechanism	NNS
cord-006229-7yoilsho	5553	15	of	of	IN
cord-006229-7yoilsho	5553	16	the	the	DT
cord-006229-7yoilsho	5553	17	DDR	DDR	NNP
cord-006229-7yoilsho	5553	18	independently	independently	RB
cord-006229-7yoilsho	5553	19	from	from	IN
cord-006229-7yoilsho	5553	20	initial	initial	JJ
cord-006229-7yoilsho	5553	21	DNA	dna	NN
cord-006229-7yoilsho	5553	22	damage	damage	NN
cord-006229-7yoilsho	5553	23	formation	formation	NN
cord-006229-7yoilsho	5553	24	.	.	.
cord-006229-7yoilsho	5554	1	With	with	IN
cord-006229-7yoilsho	5554	2	respect	respect	NN
cord-006229-7yoilsho	5554	3	to	to	IN
cord-006229-7yoilsho	5554	4	the	the	DT
cord-006229-7yoilsho	5554	5	clinic	clinic	NN
cord-006229-7yoilsho	5554	6	,	,	,
cord-006229-7yoilsho	5554	7	the	the	DT
cord-006229-7yoilsho	5554	8	data	datum	NNS
cord-006229-7yoilsho	5554	9	indicate	indicate	VBP
cord-006229-7yoilsho	5554	10	that	that	IN
cord-006229-7yoilsho	5554	11	lovastatin	lovastatin	NN
cord-006229-7yoilsho	5554	12	might	may	MD
cord-006229-7yoilsho	5554	13	be	be	VB
cord-006229-7yoilsho	5554	14	useful	useful	JJ
cord-006229-7yoilsho	5554	15	to	to	TO
cord-006229-7yoilsho	5554	16	mitigate	mitigate	VB
cord-006229-7yoilsho	5554	17	cisplatin	cisplatin	NN
cord-006229-7yoilsho	5554	18	-	-	HYPH
cord-006229-7yoilsho	5554	19	induced	induce	VBN
cord-006229-7yoilsho	5554	20	nephrotoxicity	nephrotoxicity	NN
cord-006229-7yoilsho	5554	21	.	.	.
cord-006229-7yoilsho	5555	1	The	the	DT
cord-006229-7yoilsho	5555	2	influence	influence	NN
cord-006229-7yoilsho	5555	3	of	of	IN
cord-006229-7yoilsho	5555	4	oxidant	oxidant	JJ
cord-006229-7yoilsho	5555	5	tert	tert	NNP
cord-006229-7yoilsho	5555	6	-	-	HYPH
cord-006229-7yoilsho	5555	7	butylhydrochinone	butylhydrochinone	NNP
cord-006229-7yoilsho	5555	8	(	(	-LRB-
cord-006229-7yoilsho	5555	9	tBHQ	tBHQ	NNP
cord-006229-7yoilsho	5555	10	)	)	-RRB-
cord-006229-7yoilsho	5555	11	on	on	IN
cord-006229-7yoilsho	5555	12	endothelial	endothelial	JJ
cord-006229-7yoilsho	5555	13	cell	cell	NN
cord-006229-7yoilsho	5555	14	migration	migration	NN
cord-006229-7yoilsho	5555	15	in	in	IN
cord-006229-7yoilsho	5555	16	WRN	wrn	NN
cord-006229-7yoilsho	5555	17	-	-	HYPH
cord-006229-7yoilsho	5555	18	deficient	deficient	JJ
cord-006229-7yoilsho	5555	19	cells	cell	NNS
cord-006229-7yoilsho	5555	20	K.	K.	NNP
cord-006229-7yoilsho	5555	21	Laarmann	Laarmann	NNP
cord-006229-7yoilsho	5555	22	1	1	CD
cord-006229-7yoilsho	5555	23	,	,	,
cord-006229-7yoilsho	5555	24	G.	G.	NNP
cord-006229-7yoilsho	5555	25	Fritz	Fritz	NNP
cord-006229-7yoilsho	5555	26	1	1	CD
cord-006229-7yoilsho	5555	27	1	1	CD
cord-006229-7yoilsho	5555	28	Institut	Institut	NNP
cord-006229-7yoilsho	5555	29	für	für	IN
cord-006229-7yoilsho	5555	30	Toxikologie	Toxikologie	NNP
cord-006229-7yoilsho	5555	31	,	,	,
cord-006229-7yoilsho	5555	32	Düsseldorf	Düsseldorf	NNP
cord-006229-7yoilsho	5555	33	,	,	,
cord-006229-7yoilsho	5555	34	Germany	Germany	NNP
cord-006229-7yoilsho	5555	35	Introduction	introduction	NN
cord-006229-7yoilsho	5555	36	:	:	:
cord-006229-7yoilsho	5555	37	WRN	WRN	NNP
cord-006229-7yoilsho	5555	38	is	be	VBZ
cord-006229-7yoilsho	5555	39	a	a	DT
cord-006229-7yoilsho	5555	40	DNA	dna	NN
cord-006229-7yoilsho	5555	41	helicase	helicase	NN
cord-006229-7yoilsho	5555	42	and	and	CC
cord-006229-7yoilsho	5555	43	possesses	possess	VBZ
cord-006229-7yoilsho	5555	44	a	a	DT
cord-006229-7yoilsho	5555	45	3´-5´exonuclease	3´-5´exonuclease	CD
cord-006229-7yoilsho	5555	46	and	and	CC
cord-006229-7yoilsho	5555	47	ATPase	atpase	NN
cord-006229-7yoilsho	5555	48	activity	activity	NN
cord-006229-7yoilsho	5555	49	as	as	RB
cord-006229-7yoilsho	5555	50	well	well	RB
cord-006229-7yoilsho	5555	51	as	as	IN
cord-006229-7yoilsho	5555	52	a	a	DT
cord-006229-7yoilsho	5555	53	single	single	JJ
cord-006229-7yoilsho	5555	54	strand	strand	NN
cord-006229-7yoilsho	5555	55	annealing	anneal	VBG
cord-006229-7yoilsho	5555	56	activity	activity	NN
cord-006229-7yoilsho	5555	57	.	.	.
cord-006229-7yoilsho	5556	1	It	-PRON-	PRP
cord-006229-7yoilsho	5556	2	is	be	VBZ
cord-006229-7yoilsho	5556	3	involved	involve	VBN
cord-006229-7yoilsho	5556	4	in	in	IN
cord-006229-7yoilsho	5556	5	DNA	dna	NN
cord-006229-7yoilsho	5556	6	repair	repair	NN
cord-006229-7yoilsho	5556	7	,	,	,
cord-006229-7yoilsho	5556	8	by	by	IN
cord-006229-7yoilsho	5556	9	interacting	interact	VBG
cord-006229-7yoilsho	5556	10	with	with	IN
cord-006229-7yoilsho	5556	11	proteins	protein	NNS
cord-006229-7yoilsho	5556	12	of	of	IN
cord-006229-7yoilsho	5556	13	base	base	NN
cord-006229-7yoilsho	5556	14	excision	excision	NN
cord-006229-7yoilsho	5556	15	repair	repair	NN
cord-006229-7yoilsho	5556	16	(	(	-LRB-
cord-006229-7yoilsho	5556	17	BER	BER	NNP
cord-006229-7yoilsho	5556	18	)	)	-RRB-
cord-006229-7yoilsho	5556	19	and	and	CC
cord-006229-7yoilsho	5556	20	nucleotide	nucleotide	JJ
cord-006229-7yoilsho	5556	21	excision	excision	NN
cord-006229-7yoilsho	5556	22	repair	repair	NN
cord-006229-7yoilsho	5556	23	(	(	-LRB-
cord-006229-7yoilsho	5556	24	NER	NER	NNP
cord-006229-7yoilsho	5556	25	)	)	-RRB-
cord-006229-7yoilsho	5556	26	.	.	.
cord-006229-7yoilsho	5557	1	Defects	defect	NNS
cord-006229-7yoilsho	5557	2	of	of	IN
cord-006229-7yoilsho	5557	3	WRN	WRN	NNP
cord-006229-7yoilsho	5557	4	are	be	VBP
cord-006229-7yoilsho	5557	5	marked	mark	VBN
cord-006229-7yoilsho	5557	6	by	by	IN
cord-006229-7yoilsho	5557	7	genome	genome	NN
cord-006229-7yoilsho	5557	8	instability	instability	NN
cord-006229-7yoilsho	5557	9	which	which	WDT
cord-006229-7yoilsho	5557	10	,	,	,
cord-006229-7yoilsho	5557	11	in	in	IN
cord-006229-7yoilsho	5557	12	turn	turn	NN
cord-006229-7yoilsho	5557	13	,	,	,
cord-006229-7yoilsho	5557	14	is	be	VBZ
cord-006229-7yoilsho	5557	15	caused	cause	VBN
cord-006229-7yoilsho	5557	16	by	by	IN
cord-006229-7yoilsho	5557	17	defects	defect	NNS
cord-006229-7yoilsho	5557	18	in	in	IN
cord-006229-7yoilsho	5557	19	DNA	dna	NN
cord-006229-7yoilsho	5557	20	damage	damage	NN
cord-006229-7yoilsho	5557	21	repair	repair	NN
cord-006229-7yoilsho	5557	22	.	.	.
cord-006229-7yoilsho	5558	1	Patients	patient	NNS
cord-006229-7yoilsho	5558	2	with	with	IN
cord-006229-7yoilsho	5558	3	a	a	DT
cord-006229-7yoilsho	5558	4	mutation	mutation	NN
cord-006229-7yoilsho	5558	5	in	in	IN
cord-006229-7yoilsho	5558	6	the	the	DT
cord-006229-7yoilsho	5558	7	WRN	WRN	NNP
cord-006229-7yoilsho	5558	8	gene	gene	NN
cord-006229-7yoilsho	5558	9	show	show	VBP
cord-006229-7yoilsho	5558	10	premature	premature	JJ
cord-006229-7yoilsho	5558	11	aging	aging	NN
cord-006229-7yoilsho	5558	12	and	and	CC
cord-006229-7yoilsho	5558	13	early	early	JJ
cord-006229-7yoilsho	5558	14	mortality	mortality	NN
cord-006229-7yoilsho	5558	15	.	.	.
cord-006229-7yoilsho	5559	1	The	the	DT
cord-006229-7yoilsho	5559	2	latter	latter	JJ
cord-006229-7yoilsho	5559	3	is	be	VBZ
cord-006229-7yoilsho	5559	4	mainly	mainly	RB
cord-006229-7yoilsho	5559	5	caused	cause	VBN
cord-006229-7yoilsho	5559	6	by	by	IN
cord-006229-7yoilsho	5559	7	arteriosclerosis	arteriosclerosis	NN
cord-006229-7yoilsho	5559	8	.	.	.
cord-006229-7yoilsho	5560	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	5560	2	,	,	,
cord-006229-7yoilsho	5560	3	WRN	WRN	NNP
cord-006229-7yoilsho	5560	4	participates	participate	VBZ
cord-006229-7yoilsho	5560	5	in	in	IN
cord-006229-7yoilsho	5560	6	the	the	DT
cord-006229-7yoilsho	5560	7	regulation	regulation	NN
cord-006229-7yoilsho	5560	8	of	of	IN
cord-006229-7yoilsho	5560	9	genotoxic	genotoxic	JJ
cord-006229-7yoilsho	5560	10	stress	stress	NN
cord-006229-7yoilsho	5560	11	responses	response	NNS
cord-006229-7yoilsho	5560	12	stimulated	stimulate	VBN
cord-006229-7yoilsho	5560	13	by	by	IN
cord-006229-7yoilsho	5560	14	reactive	reactive	JJ
cord-006229-7yoilsho	5560	15	oxygen	oxygen	NN
cord-006229-7yoilsho	5560	16	species	specie	NNS
cord-006229-7yoilsho	5560	17	(	(	-LRB-
cord-006229-7yoilsho	5560	18	ROS	ROS	NNP
cord-006229-7yoilsho	5560	19	)	)	-RRB-
cord-006229-7yoilsho	5560	20	and	and	CC
cord-006229-7yoilsho	5560	21	alkylating	alkylating	JJ
cord-006229-7yoilsho	5560	22	agents	agent	NNS
cord-006229-7yoilsho	5560	23	.	.	.
cord-006229-7yoilsho	5561	1	The	the	DT
cord-006229-7yoilsho	5561	2	aim	aim	NN
cord-006229-7yoilsho	5561	3	of	of	IN
cord-006229-7yoilsho	5561	4	this	this	DT
cord-006229-7yoilsho	5561	5	study	study	NN
cord-006229-7yoilsho	5561	6	was	be	VBD
cord-006229-7yoilsho	5561	7	(	(	-LRB-
cord-006229-7yoilsho	5561	8	i	i	NN
cord-006229-7yoilsho	5561	9	)	)	-RRB-
cord-006229-7yoilsho	5561	10	to	to	TO
cord-006229-7yoilsho	5561	11	investigate	investigate	VB
cord-006229-7yoilsho	5561	12	whether	whether	IN
cord-006229-7yoilsho	5561	13	endothelial	endothelial	JJ
cord-006229-7yoilsho	5561	14	cell	cell	NN
cord-006229-7yoilsho	5561	15	migration	migration	NN
cord-006229-7yoilsho	5561	16	and	and	CC
cord-006229-7yoilsho	5561	17	adhesion	adhesion	NN
cord-006229-7yoilsho	5561	18	were	be	VBD
cord-006229-7yoilsho	5561	19	effected	effect	VBN
cord-006229-7yoilsho	5561	20	by	by	IN
cord-006229-7yoilsho	5561	21	sub	sub	JJ
cord-006229-7yoilsho	5561	22	-	-	JJ
cord-006229-7yoilsho	5561	23	toxic	toxic	JJ
cord-006229-7yoilsho	5561	24	(	(	-LRB-
cord-006229-7yoilsho	5561	25	IC	IC	NNP
cord-006229-7yoilsho	5561	26	10	10	CD
cord-006229-7yoilsho	5561	27	)	)	-RRB-
cord-006229-7yoilsho	5561	28	and	and	CC
cord-006229-7yoilsho	5561	29	moderate	moderate	JJ
cord-006229-7yoilsho	5561	30	toxic	toxic	JJ
cord-006229-7yoilsho	5561	31	(	(	-LRB-
cord-006229-7yoilsho	5561	32	IC	IC	NNP
cord-006229-7yoilsho	5561	33	40	40	CD
cord-006229-7yoilsho	5561	34	)	)	-RRB-
cord-006229-7yoilsho	5561	35	concentrations	concentration	NNS
cord-006229-7yoilsho	5561	36	of	of	IN
cord-006229-7yoilsho	5561	37	the	the	DT
cord-006229-7yoilsho	5561	38	oxidant	oxidant	JJ
cord-006229-7yoilsho	5561	39	tertbutylhydrochinone	tertbutylhydrochinone	NN
cord-006229-7yoilsho	5561	40	(	(	-LRB-
cord-006229-7yoilsho	5561	41	tBHQ	tBHQ	NNP
cord-006229-7yoilsho	5561	42	)	)	-RRB-
cord-006229-7yoilsho	5561	43	and	and	CC
cord-006229-7yoilsho	5561	44	(	(	-LRB-
cord-006229-7yoilsho	5561	45	ii	ii	NN
cord-006229-7yoilsho	5561	46	)	)	-RRB-
cord-006229-7yoilsho	5561	47	whether	whether	IN
cord-006229-7yoilsho	5561	48	WRN	WRN	NNP
cord-006229-7yoilsho	5561	49	influences	influence	VBZ
cord-006229-7yoilsho	5561	50	migration	migration	NN
cord-006229-7yoilsho	5561	51	and	and	CC
cord-006229-7yoilsho	5561	52	adhesion	adhesion	NN
cord-006229-7yoilsho	5561	53	in	in	IN
cord-006229-7yoilsho	5561	54	the	the	DT
cord-006229-7yoilsho	5561	55	presence	presence	NN
cord-006229-7yoilsho	5561	56	or	or	CC
cord-006229-7yoilsho	5561	57	absence	absence	NN
cord-006229-7yoilsho	5561	58	of	of	IN
cord-006229-7yoilsho	5561	59	tBHQ	tbhq	CD
cord-006229-7yoilsho	5561	60	.	.	.
cord-006229-7yoilsho	5562	1	Methods	method	NNS
cord-006229-7yoilsho	5562	2	:	:	:
cord-006229-7yoilsho	5563	1	Endothelial	endothelial	NN
cord-006229-7yoilsho	5563	2	-	-	HYPH
cord-006229-7yoilsho	5563	3	like	like	JJ
cord-006229-7yoilsho	5563	4	EA.hy926	EA.hy926	NNP
cord-006229-7yoilsho	5563	5	cells	cell	NNS
cord-006229-7yoilsho	5563	6	were	be	VBD
cord-006229-7yoilsho	5563	7	treated	treat	VBN
cord-006229-7yoilsho	5563	8	with	with	IN
cord-006229-7yoilsho	5563	9	different	different	JJ
cord-006229-7yoilsho	5563	10	concentrations	concentration	NNS
cord-006229-7yoilsho	5563	11	of	of	IN
cord-006229-7yoilsho	5563	12	the	the	DT
cord-006229-7yoilsho	5563	13	redox	redox	NN
cord-006229-7yoilsho	5563	14	cycling	cycling	NN
cord-006229-7yoilsho	5563	15	and	and	CC
cord-006229-7yoilsho	5563	16	thus	thus	RB
cord-006229-7yoilsho	5563	17	ROS	ROS	NNP
cord-006229-7yoilsho	5563	18	producing	produce	VBG
cord-006229-7yoilsho	5563	19	oxidant	oxidant	JJ
cord-006229-7yoilsho	5563	20	tBHQ	tbhq	NN
cord-006229-7yoilsho	5563	21	.	.	.
cord-006229-7yoilsho	5564	1	Viability	viability	NN
cord-006229-7yoilsho	5564	2	was	be	VBD
cord-006229-7yoilsho	5564	3	measured	measure	VBN
cord-006229-7yoilsho	5564	4	by	by	IN
cord-006229-7yoilsho	5564	5	the	the	DT
cord-006229-7yoilsho	5564	6	Alamar	Alamar	NNP
cord-006229-7yoilsho	5564	7	Blue	Blue	NNP
cord-006229-7yoilsho	5564	8	assay	assay	NN
cord-006229-7yoilsho	5564	9	.	.	.
cord-006229-7yoilsho	5565	1	IC	IC	NNP
cord-006229-7yoilsho	5565	2	10	10	CD
cord-006229-7yoilsho	5565	3	and	and	CC
cord-006229-7yoilsho	5565	4	IC	IC	NNP
cord-006229-7yoilsho	5565	5	40	40	CD
cord-006229-7yoilsho	5565	6	were	be	VBD
cord-006229-7yoilsho	5565	7	determined	determine	VBN
cord-006229-7yoilsho	5565	8	after	after	IN
cord-006229-7yoilsho	5565	9	24h	24h	NNS
cord-006229-7yoilsho	5565	10	permanent	permanent	JJ
cord-006229-7yoilsho	5565	11	treatment	treatment	NN
cord-006229-7yoilsho	5565	12	.	.	.
cord-006229-7yoilsho	5566	1	To	to	TO
cord-006229-7yoilsho	5566	2	investigate	investigate	VB
cord-006229-7yoilsho	5566	3	the	the	DT
cord-006229-7yoilsho	5566	4	influence	influence	NN
cord-006229-7yoilsho	5566	5	of	of	IN
cord-006229-7yoilsho	5566	6	WRN	WRN	NNP
cord-006229-7yoilsho	5566	7	on	on	IN
cord-006229-7yoilsho	5566	8	endothelial	endothelial	JJ
cord-006229-7yoilsho	5566	9	cell	cell	NN
cord-006229-7yoilsho	5566	10	migration	migration	NN
cord-006229-7yoilsho	5566	11	and	and	CC
cord-006229-7yoilsho	5566	12	adhesion	adhesion	NN
cord-006229-7yoilsho	5566	13	,	,	,
cord-006229-7yoilsho	5566	14	a	a	DT
cord-006229-7yoilsho	5566	15	WRN	WRN	NNP
cord-006229-7yoilsho	5566	16	knock	knock	NN
cord-006229-7yoilsho	5566	17	-	-	HYPH
cord-006229-7yoilsho	5566	18	down	down	NN
cord-006229-7yoilsho	5566	19	was	be	VBD
cord-006229-7yoilsho	5566	20	performed	perform	VBN
cord-006229-7yoilsho	5566	21	in	in	IN
cord-006229-7yoilsho	5566	22	EA.hy926	EA.hy926	NNP
cord-006229-7yoilsho	5566	23	cells	cell	NNS
cord-006229-7yoilsho	5566	24	using	use	VBG
cord-006229-7yoilsho	5566	25	RNA	RNA	NNP
cord-006229-7yoilsho	5566	26	interference	interference	NN
cord-006229-7yoilsho	5566	27	.	.	.
cord-006229-7yoilsho	5567	1	To	to	TO
cord-006229-7yoilsho	5567	2	measure	measure	VB
cord-006229-7yoilsho	5567	3	migration	migration	NN
cord-006229-7yoilsho	5567	4	,	,	,
cord-006229-7yoilsho	5567	5	a	a	DT
cord-006229-7yoilsho	5567	6	confluent	confluent	JJ
cord-006229-7yoilsho	5567	7	cell	cell	NN
cord-006229-7yoilsho	5567	8	monolayer	monolayer	NN
cord-006229-7yoilsho	5567	9	was	be	VBD
cord-006229-7yoilsho	5567	10	scratched	scratch	VBN
cord-006229-7yoilsho	5567	11	using	use	VBG
cord-006229-7yoilsho	5567	12	a	a	DT
cord-006229-7yoilsho	5567	13	pipet	pipet	JJ
cord-006229-7yoilsho	5567	14	tip	tip	NN
cord-006229-7yoilsho	5567	15	,	,	,
cord-006229-7yoilsho	5567	16	24h	24h	NNS
cord-006229-7yoilsho	5567	17	after	after	IN
cord-006229-7yoilsho	5567	18	permanent	permanent	JJ
cord-006229-7yoilsho	5567	19	tBHQ	tbhq	CD
cord-006229-7yoilsho	5567	20	treatment	treatment	NN
cord-006229-7yoilsho	5567	21	.	.	.
cord-006229-7yoilsho	5568	1	Pictures	picture	NNS
cord-006229-7yoilsho	5568	2	were	be	VBD
cord-006229-7yoilsho	5568	3	taken	take	VBN
cord-006229-7yoilsho	5568	4	at	at	IN
cord-006229-7yoilsho	5568	5	the	the	DT
cord-006229-7yoilsho	5568	6	time	time	NN
cord-006229-7yoilsho	5568	7	points	point	NNS
cord-006229-7yoilsho	5568	8	0h	0h	NNP
cord-006229-7yoilsho	5568	9	,	,	,
cord-006229-7yoilsho	5568	10	4h	4h	NNP
cord-006229-7yoilsho	5568	11	and	and	CC
cord-006229-7yoilsho	5568	12	8h	8h	NNP
cord-006229-7yoilsho	5568	13	after	after	IN
cord-006229-7yoilsho	5568	14	performing	perform	VBG
cord-006229-7yoilsho	5568	15	the	the	DT
cord-006229-7yoilsho	5568	16	scratch	scratch	NN
cord-006229-7yoilsho	5568	17	.	.	.
cord-006229-7yoilsho	5569	1	The	the	DT
cord-006229-7yoilsho	5569	2	non	non	JJ
cord-006229-7yoilsho	5569	3	-	-	JJ
cord-006229-7yoilsho	5569	4	closed	closed	JJ
cord-006229-7yoilsho	5569	5	area	area	NN
cord-006229-7yoilsho	5569	6	was	be	VBD
cord-006229-7yoilsho	5569	7	measured	measure	VBN
cord-006229-7yoilsho	5569	8	.	.	.
cord-006229-7yoilsho	5570	1	In	in	IN
cord-006229-7yoilsho	5570	2	a	a	DT
cord-006229-7yoilsho	5570	3	second	second	JJ
cord-006229-7yoilsho	5570	4	part	part	NN
cord-006229-7yoilsho	5570	5	,	,	,
cord-006229-7yoilsho	5570	6	adhesion	adhesion	NN
cord-006229-7yoilsho	5570	7	of	of	IN
cord-006229-7yoilsho	5570	8	the	the	DT
cord-006229-7yoilsho	5570	9	calcein	calcein	NNP
cord-006229-7yoilsho	5570	10	-	-	HYPH
cord-006229-7yoilsho	5570	11	labeled	label	VBN
cord-006229-7yoilsho	5570	12	colon	colon	NN
cord-006229-7yoilsho	5570	13	adenocarcinoma	adenocarcinoma	NN
cord-006229-7yoilsho	5570	14	HT-29	HT-29	NNP
cord-006229-7yoilsho	5570	15	cell	cell	NN
cord-006229-7yoilsho	5570	16	line	line	NN
cord-006229-7yoilsho	5570	17	on	on	IN
cord-006229-7yoilsho	5570	18	the	the	DT
cord-006229-7yoilsho	5570	19	EA.hy926	EA.hy926	NNP
cord-006229-7yoilsho	5570	20	monolayer	monolayer	NN
cord-006229-7yoilsho	5570	21	was	be	VBD
cord-006229-7yoilsho	5570	22	investigated	investigate	VBN
cord-006229-7yoilsho	5570	23	.	.	.
cord-006229-7yoilsho	5571	1	WRN	wrn	NN
cord-006229-7yoilsho	5571	2	-	-	HYPH
cord-006229-7yoilsho	5571	3	deficient	deficient	JJ
cord-006229-7yoilsho	5571	4	or	or	CC
cord-006229-7yoilsho	5571	5	non	non	JJ
cord-006229-7yoilsho	5571	6	-	-	JJ
cord-006229-7yoilsho	5571	7	deficient	deficient	JJ
cord-006229-7yoilsho	5571	8	cells	cell	NNS
cord-006229-7yoilsho	5571	9	were	be	VBD
cord-006229-7yoilsho	5571	10	treated	treat	VBN
cord-006229-7yoilsho	5571	11	with	with	IN
cord-006229-7yoilsho	5571	12	100	100	CD
cord-006229-7yoilsho	5571	13	µM	µM	NNS
cord-006229-7yoilsho	5571	14	and	and	CC
cord-006229-7yoilsho	5571	15	160	160	CD
cord-006229-7yoilsho	5571	16	µM	µm	CD
cord-006229-7yoilsho	5571	17	tBHQ	tBHQ	NNS
cord-006229-7yoilsho	5571	18	or	or	CC
cord-006229-7yoilsho	5571	19	with	with	IN
cord-006229-7yoilsho	5571	20	TNFα	TNFα	NNS
cord-006229-7yoilsho	5571	21	.	.	.
cord-006229-7yoilsho	5572	1	Results	result	NNS
cord-006229-7yoilsho	5572	2	:	:	:
cord-006229-7yoilsho	5573	1	For	for	IN
cord-006229-7yoilsho	5573	2	EA.hy926	EA.hy926	NNP
cord-006229-7yoilsho	5573	3	cells	cell	NNS
cord-006229-7yoilsho	5573	4	,	,	,
cord-006229-7yoilsho	5573	5	100	100	CD
cord-006229-7yoilsho	5573	6	µM	µm	NN
cord-006229-7yoilsho	5573	7	and	and	CC
cord-006229-7yoilsho	5573	8	160	160	CD
cord-006229-7yoilsho	5573	9	µM	µm	CD
cord-006229-7yoilsho	5573	10	tBHQ	tbhq	CD
cord-006229-7yoilsho	5573	11	were	be	VBD
cord-006229-7yoilsho	5573	12	determined	determine	VBN
cord-006229-7yoilsho	5573	13	as	as	IN
cord-006229-7yoilsho	5573	14	IC	IC	NNP
cord-006229-7yoilsho	5573	15	10	10	CD
cord-006229-7yoilsho	5573	16	and	and	CC
cord-006229-7yoilsho	5573	17	IC	IC	NNP
cord-006229-7yoilsho	5573	18	40	40	CD
cord-006229-7yoilsho	5573	19	,	,	,
cord-006229-7yoilsho	5573	20	respectively	respectively	RB
cord-006229-7yoilsho	5573	21	.	.	.
cord-006229-7yoilsho	5574	1	Performing	perform	VBG
cord-006229-7yoilsho	5574	2	the	the	DT
cord-006229-7yoilsho	5574	3	migration	migration	NN
cord-006229-7yoilsho	5574	4	assay	assay	NN
cord-006229-7yoilsho	5574	5	,	,	,
cord-006229-7yoilsho	5574	6	EA.hy926	EA.hy926	NNP
cord-006229-7yoilsho	5574	7	cells	cell	NNS
cord-006229-7yoilsho	5574	8	showed	show	VBD
cord-006229-7yoilsho	5574	9	75	75	CD
cord-006229-7yoilsho	5574	10	%	%	NN
cord-006229-7yoilsho	5574	11	gap	gap	NN
cord-006229-7yoilsho	5574	12	closure	closure	NN
cord-006229-7yoilsho	5574	13	,	,	,
cord-006229-7yoilsho	5574	14	whereas	whereas	IN
cord-006229-7yoilsho	5574	15	WRN	wrn	NN
cord-006229-7yoilsho	5574	16	-	-	HYPH
cord-006229-7yoilsho	5574	17	deficient	deficient	JJ
cord-006229-7yoilsho	5574	18	cells	cell	NNS
cord-006229-7yoilsho	5574	19	showed	show	VBD
cord-006229-7yoilsho	5574	20	a	a	DT
cord-006229-7yoilsho	5574	21	closure	closure	NN
cord-006229-7yoilsho	5574	22	of	of	IN
cord-006229-7yoilsho	5574	23	only	only	RB
cord-006229-7yoilsho	5574	24	35	35	CD
cord-006229-7yoilsho	5574	25	%	%	NN
cord-006229-7yoilsho	5574	26	after	after	IN
cord-006229-7yoilsho	5574	27	8h	8h	NNP
cord-006229-7yoilsho	5574	28	.	.	.
cord-006229-7yoilsho	5575	1	The	the	DT
cord-006229-7yoilsho	5575	2	gap	gap	NN
cord-006229-7yoilsho	5575	3	was	be	VBD
cord-006229-7yoilsho	5575	4	closed	close	VBN
cord-006229-7yoilsho	5575	5	of	of	IN
cord-006229-7yoilsho	5575	6	65	65	CD
cord-006229-7yoilsho	5575	7	%	%	NN
cord-006229-7yoilsho	5575	8	and	and	CC
cord-006229-7yoilsho	5575	9	55	55	CD
cord-006229-7yoilsho	5575	10	%	%	NN
cord-006229-7yoilsho	5575	11	after	after	IN
cord-006229-7yoilsho	5575	12	100	100	CD
cord-006229-7yoilsho	5575	13	µM	µm	NN
cord-006229-7yoilsho	5575	14	and	and	CC
cord-006229-7yoilsho	5575	15	160	160	CD
cord-006229-7yoilsho	5575	16	µM	µm	CD
cord-006229-7yoilsho	5575	17	tBHQ	tbhq	CD
cord-006229-7yoilsho	5575	18	treatment	treatment	NN
cord-006229-7yoilsho	5575	19	.	.	.
cord-006229-7yoilsho	5576	1	In	in	IN
cord-006229-7yoilsho	5576	2	WRNdeficient	wrndeficient	NN
cord-006229-7yoilsho	5576	3	cells	cell	NNS
cord-006229-7yoilsho	5576	4	no	no	DT
cord-006229-7yoilsho	5576	5	remarkable	remarkable	JJ
cord-006229-7yoilsho	5576	6	effect	effect	NN
cord-006229-7yoilsho	5576	7	on	on	IN
cord-006229-7yoilsho	5576	8	migration	migration	NN
cord-006229-7yoilsho	5576	9	was	be	VBD
cord-006229-7yoilsho	5576	10	observed	observe	VBN
cord-006229-7yoilsho	5576	11	after	after	IN
cord-006229-7yoilsho	5576	12	100	100	CD
cord-006229-7yoilsho	5576	13	µM	µm	CD
cord-006229-7yoilsho	5576	14	tBHQ	tbhq	CD
cord-006229-7yoilsho	5576	15	treatment	treatment	NN
cord-006229-7yoilsho	5576	16	,	,	,
cord-006229-7yoilsho	5576	17	whereas	whereas	IN
cord-006229-7yoilsho	5576	18	the	the	DT
cord-006229-7yoilsho	5576	19	treatment	treatment	NN
cord-006229-7yoilsho	5576	20	with	with	IN
cord-006229-7yoilsho	5576	21	160	160	CD
cord-006229-7yoilsho	5576	22	µM	µm	CD
cord-006229-7yoilsho	5576	23	tBHQ	tbhq	NN
cord-006229-7yoilsho	5576	24	showed	show	VBD
cord-006229-7yoilsho	5576	25	a	a	DT
cord-006229-7yoilsho	5576	26	slight	slight	JJ
cord-006229-7yoilsho	5576	27	decrease	decrease	NN
cord-006229-7yoilsho	5576	28	in	in	IN
cord-006229-7yoilsho	5576	29	migration	migration	NN
cord-006229-7yoilsho	5576	30	of	of	IN
cord-006229-7yoilsho	5576	31	about	about	IN
cord-006229-7yoilsho	5576	32	10	10	CD
cord-006229-7yoilsho	5576	33	%	%	NN
cord-006229-7yoilsho	5576	34	compared	compare	VBN
cord-006229-7yoilsho	5576	35	to	to	IN
cord-006229-7yoilsho	5576	36	WRN	wrn	NN
cord-006229-7yoilsho	5576	37	-	-	HYPH
cord-006229-7yoilsho	5576	38	deficient	deficient	JJ
cord-006229-7yoilsho	5576	39	cells	cell	NNS
cord-006229-7yoilsho	5576	40	.	.	.
cord-006229-7yoilsho	5577	1	No	no	DT
cord-006229-7yoilsho	5577	2	effect	effect	NN
cord-006229-7yoilsho	5577	3	on	on	IN
cord-006229-7yoilsho	5577	4	adhesion	adhesion	NN
cord-006229-7yoilsho	5577	5	was	be	VBD
cord-006229-7yoilsho	5577	6	observed	observe	VBN
cord-006229-7yoilsho	5577	7	after	after	IN
cord-006229-7yoilsho	5577	8	TNFα	TNFα	NNP
cord-006229-7yoilsho	5577	9	treatment	treatment	NN
cord-006229-7yoilsho	5577	10	.	.	.
cord-006229-7yoilsho	5578	1	After	after	IN
cord-006229-7yoilsho	5578	2	160	160	CD
cord-006229-7yoilsho	5578	3	µM	µm	CD
cord-006229-7yoilsho	5578	4	tBHQ	tbhq	CD
cord-006229-7yoilsho	5578	5	treatment	treatment	NN
cord-006229-7yoilsho	5578	6	a	a	DT
cord-006229-7yoilsho	5578	7	slight	slight	JJ
cord-006229-7yoilsho	5578	8	increase	increase	NN
cord-006229-7yoilsho	5578	9	of	of	IN
cord-006229-7yoilsho	5578	10	adhesion	adhesion	NN
cord-006229-7yoilsho	5578	11	was	be	VBD
cord-006229-7yoilsho	5578	12	detected	detect	VBN
cord-006229-7yoilsho	5578	13	in	in	IN
cord-006229-7yoilsho	5578	14	EA.hy926	EA.hy926	NNP
cord-006229-7yoilsho	5578	15	cells	cell	NNS
cord-006229-7yoilsho	5578	16	.	.	.
cord-006229-7yoilsho	5579	1	The	the	DT
cord-006229-7yoilsho	5579	2	influence	influence	NN
cord-006229-7yoilsho	5579	3	of	of	IN
cord-006229-7yoilsho	5579	4	moderate	moderate	JJ
cord-006229-7yoilsho	5579	5	tBHQ	tbhq	JJ
cord-006229-7yoilsho	5579	6	concentration	concentration	NN
cord-006229-7yoilsho	5579	7	on	on	IN
cord-006229-7yoilsho	5579	8	adhesion	adhesion	NN
cord-006229-7yoilsho	5579	9	was	be	VBD
cord-006229-7yoilsho	5579	10	reduced	reduce	VBN
cord-006229-7yoilsho	5579	11	in	in	IN
cord-006229-7yoilsho	5579	12	the	the	DT
cord-006229-7yoilsho	5579	13	absence	absence	NN
cord-006229-7yoilsho	5579	14	of	of	IN
cord-006229-7yoilsho	5579	15	WRN	WRN	NNP
cord-006229-7yoilsho	5579	16	.	.	.
cord-006229-7yoilsho	5580	1	Conclusion	conclusion	NN
cord-006229-7yoilsho	5580	2	:	:	:
cord-006229-7yoilsho	5581	1	WRN	WRN	NNP
cord-006229-7yoilsho	5581	2	influences	influence	VBZ
cord-006229-7yoilsho	5581	3	endothelial	endothelial	JJ
cord-006229-7yoilsho	5581	4	cell	cell	NN
cord-006229-7yoilsho	5581	5	migration	migration	NN
cord-006229-7yoilsho	5581	6	.	.	.
cord-006229-7yoilsho	5582	1	In	in	IN
cord-006229-7yoilsho	5582	2	contrast	contrast	NN
cord-006229-7yoilsho	5582	3	to	to	IN
cord-006229-7yoilsho	5582	4	wild	wild	JJ
cord-006229-7yoilsho	5582	5	-	-	HYPH
cord-006229-7yoilsho	5582	6	type	type	NN
cord-006229-7yoilsho	5582	7	EA.hy926	EA.hy926	NNP
cord-006229-7yoilsho	5582	8	cells	cell	NNS
cord-006229-7yoilsho	5582	9	,	,	,
cord-006229-7yoilsho	5582	10	no	no	DT
cord-006229-7yoilsho	5582	11	significant	significant	JJ
cord-006229-7yoilsho	5582	12	effect	effect	NN
cord-006229-7yoilsho	5582	13	of	of	IN
cord-006229-7yoilsho	5582	14	tBHQ	tbhq	NN
cord-006229-7yoilsho	5582	15	was	be	VBD
cord-006229-7yoilsho	5582	16	observed	observe	VBN
cord-006229-7yoilsho	5582	17	on	on	IN
cord-006229-7yoilsho	5582	18	migration	migration	NN
cord-006229-7yoilsho	5582	19	of	of	IN
cord-006229-7yoilsho	5582	20	WRNdeficient	wrndeficient	NN
cord-006229-7yoilsho	5582	21	cells	cell	NNS
cord-006229-7yoilsho	5582	22	.	.	.
cord-006229-7yoilsho	5583	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	5583	2	,	,	,
cord-006229-7yoilsho	5583	3	the	the	DT
cord-006229-7yoilsho	5583	4	moderate	moderate	JJ
cord-006229-7yoilsho	5583	5	toxic	toxic	JJ
cord-006229-7yoilsho	5583	6	concentration	concentration	NN
cord-006229-7yoilsho	5583	7	of	of	IN
cord-006229-7yoilsho	5583	8	tBHQ	tbhq	NN
cord-006229-7yoilsho	5583	9	showed	show	VBD
cord-006229-7yoilsho	5583	10	slightly	slightly	RB
cord-006229-7yoilsho	5583	11	increased	increase	VBN
cord-006229-7yoilsho	5583	12	HT-29	HT-29	NNP
cord-006229-7yoilsho	5583	13	adhesion	adhesion	NN
cord-006229-7yoilsho	5583	14	to	to	IN
cord-006229-7yoilsho	5583	15	EA.hy926	EA.hy926	NNP
cord-006229-7yoilsho	5583	16	,	,	,
cord-006229-7yoilsho	5583	17	which	which	WDT
cord-006229-7yoilsho	5583	18	was	be	VBD
cord-006229-7yoilsho	5583	19	not	not	RB
cord-006229-7yoilsho	5583	20	found	find	VBN
cord-006229-7yoilsho	5583	21	in	in	IN
cord-006229-7yoilsho	5583	22	WRN	wrn	NN
cord-006229-7yoilsho	5583	23	-	-	HYPH
cord-006229-7yoilsho	5583	24	deficient	deficient	JJ
cord-006229-7yoilsho	5583	25	cells	cell	NNS
cord-006229-7yoilsho	5583	26	.	.	.
cord-006229-7yoilsho	5584	1	Outlook	outlook	NN
cord-006229-7yoilsho	5584	2	:	:	:
cord-006229-7yoilsho	5585	1	In	in	IN
cord-006229-7yoilsho	5585	2	forthcoming	forthcoming	JJ
cord-006229-7yoilsho	5585	3	studies	study	NNS
cord-006229-7yoilsho	5585	4	we	-PRON-	PRP
cord-006229-7yoilsho	5585	5	analyse	analyse	VBP
cord-006229-7yoilsho	5585	6	the	the	DT
cord-006229-7yoilsho	5585	7	effect	effect	NN
cord-006229-7yoilsho	5585	8	of	of	IN
cord-006229-7yoilsho	5585	9	alkylating	alkylate	VBG
cord-006229-7yoilsho	5585	10	agents	agent	NNS
cord-006229-7yoilsho	5585	11	on	on	IN
cord-006229-7yoilsho	5585	12	migration	migration	NN
cord-006229-7yoilsho	5585	13	and	and	CC
cord-006229-7yoilsho	5585	14	adhesion	adhesion	NN
cord-006229-7yoilsho	5585	15	.	.	.
cord-006229-7yoilsho	5586	1	Data	datum	NNS
cord-006229-7yoilsho	5586	2	will	will	MD
cord-006229-7yoilsho	5586	3	be	be	VB
cord-006229-7yoilsho	5586	4	presented	present	VBN
cord-006229-7yoilsho	5586	5	and	and	CC
cord-006229-7yoilsho	5586	6	discussed	discuss	VBN
cord-006229-7yoilsho	5586	7	.	.	.
cord-006229-7yoilsho	5587	1	The	the	DT
cord-006229-7yoilsho	5587	2	aim	aim	NN
cord-006229-7yoilsho	5587	3	of	of	IN
cord-006229-7yoilsho	5587	4	the	the	DT
cord-006229-7yoilsho	5587	5	present	present	JJ
cord-006229-7yoilsho	5587	6	work	work	NN
cord-006229-7yoilsho	5587	7	was	be	VBD
cord-006229-7yoilsho	5587	8	to	to	TO
cord-006229-7yoilsho	5587	9	compare	compare	VB
cord-006229-7yoilsho	5587	10	the	the	DT
cord-006229-7yoilsho	5587	11	sensitivity	sensitivity	NN
cord-006229-7yoilsho	5587	12	of	of	IN
cord-006229-7yoilsho	5587	13	leukemia	leukemia	NN
cord-006229-7yoilsho	5587	14	cell	cell	NN
cord-006229-7yoilsho	5587	15	lines	line	NNS
cord-006229-7yoilsho	5587	16	(	(	-LRB-
cord-006229-7yoilsho	5587	17	HL60	HL60	NNP
cord-006229-7yoilsho	5587	18	,	,	,
cord-006229-7yoilsho	5587	19	Jurkat	Jurkat	NNP
cord-006229-7yoilsho	5587	20	and	and	CC
cord-006229-7yoilsho	5587	21	TK6	TK6	NNP
cord-006229-7yoilsho	5587	22	)	)	-RRB-
cord-006229-7yoilsho	5587	23	and	and	CC
cord-006229-7yoilsho	5587	24	hematopoietic	hematopoietic	JJ
cord-006229-7yoilsho	5587	25	stem	stem	NN
cord-006229-7yoilsho	5587	26	cells	cell	NNS
cord-006229-7yoilsho	5587	27	with	with	IN
cord-006229-7yoilsho	5587	28	regard	regard	NN
cord-006229-7yoilsho	5587	29	to	to	IN
cord-006229-7yoilsho	5587	30	the	the	DT
cord-006229-7yoilsho	5587	31	response	response	NN
cord-006229-7yoilsho	5587	32	to	to	IN
cord-006229-7yoilsho	5587	33	genotoxic	genotoxic	JJ
cord-006229-7yoilsho	5587	34	agents	agent	NNS
cord-006229-7yoilsho	5587	35	.	.	.
cord-006229-7yoilsho	5588	1	Chromosomal	chromosomal	JJ
cord-006229-7yoilsho	5588	2	damage	damage	NN
cord-006229-7yoilsho	5588	3	was	be	VBD
cord-006229-7yoilsho	5588	4	analyzed	analyze	VBN
cord-006229-7yoilsho	5588	5	by	by	IN
cord-006229-7yoilsho	5588	6	evaluation	evaluation	NN
cord-006229-7yoilsho	5588	7	of	of	IN
cord-006229-7yoilsho	5588	8	the	the	DT
cord-006229-7yoilsho	5588	9	micronucleus	micronucleus	NNP
cord-006229-7yoilsho	5588	10	frequency	frequency	NN
cord-006229-7yoilsho	5588	11	.	.	.
cord-006229-7yoilsho	5589	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	5589	2	,	,	,
cord-006229-7yoilsho	5589	3	changes	change	NNS
cord-006229-7yoilsho	5589	4	in	in	IN
cord-006229-7yoilsho	5589	5	the	the	DT
cord-006229-7yoilsho	5589	6	proliferation	proliferation	NN
cord-006229-7yoilsho	5589	7	index	index	NN
cord-006229-7yoilsho	5589	8	and	and	CC
cord-006229-7yoilsho	5589	9	the	the	DT
cord-006229-7yoilsho	5589	10	frequencies	frequency	NNS
cord-006229-7yoilsho	5589	11	of	of	IN
cord-006229-7yoilsho	5589	12	apoptotic	apoptotic	JJ
cord-006229-7yoilsho	5589	13	and	and	CC
cord-006229-7yoilsho	5589	14	mitotic	mitotic	JJ
cord-006229-7yoilsho	5589	15	cells	cell	NNS
cord-006229-7yoilsho	5589	16	were	be	VBD
cord-006229-7yoilsho	5589	17	assessed	assess	VBN
cord-006229-7yoilsho	5589	18	.	.	.
cord-006229-7yoilsho	5590	1	Several	several	JJ
cord-006229-7yoilsho	5590	2	cytostatic	cytostatic	JJ
cord-006229-7yoilsho	5590	3	drugs	drug	NNS
cord-006229-7yoilsho	5590	4	with	with	IN
cord-006229-7yoilsho	5590	5	different	different	JJ
cord-006229-7yoilsho	5590	6	mechanisms	mechanism	NNS
cord-006229-7yoilsho	5590	7	of	of	IN
cord-006229-7yoilsho	5590	8	action	action	NN
cord-006229-7yoilsho	5590	9	were	be	VBD
cord-006229-7yoilsho	5590	10	used	use	VBN
cord-006229-7yoilsho	5590	11	as	as	IN
cord-006229-7yoilsho	5590	12	genotoxic	genotoxic	JJ
cord-006229-7yoilsho	5590	13	agents	agent	NNS
cord-006229-7yoilsho	5590	14	.	.	.
cord-006229-7yoilsho	5591	1	Doxorubicin	Doxorubicin	NNP
cord-006229-7yoilsho	5591	2	was	be	VBD
cord-006229-7yoilsho	5591	3	used	use	VBN
cord-006229-7yoilsho	5591	4	as	as	IN
cord-006229-7yoilsho	5591	5	an	an	DT
cord-006229-7yoilsho	5591	6	intercalator	intercalator	NN
cord-006229-7yoilsho	5591	7	,	,	,
cord-006229-7yoilsho	5591	8	radical	radical	JJ
cord-006229-7yoilsho	5591	9	producer	producer	NN
cord-006229-7yoilsho	5591	10	and	and	CC
cord-006229-7yoilsho	5591	11	topoisomerase	topoisomerase	NN
cord-006229-7yoilsho	5591	12	II	ii	CD
cord-006229-7yoilsho	5591	13	inhibitor	inhibitor	NN
cord-006229-7yoilsho	5591	14	.	.	.
cord-006229-7yoilsho	5592	1	Also	also	RB
cord-006229-7yoilsho	5592	2	,	,	,
cord-006229-7yoilsho	5592	3	the	the	DT
cord-006229-7yoilsho	5592	4	effects	effect	NNS
cord-006229-7yoilsho	5592	5	of	of	IN
cord-006229-7yoilsho	5592	6	vinblastine	vinblastine	NN
cord-006229-7yoilsho	5592	7	,	,	,
cord-006229-7yoilsho	5592	8	a	a	DT
cord-006229-7yoilsho	5592	9	mitosis	mitosis	NN
cord-006229-7yoilsho	5592	10	-	-	HYPH
cord-006229-7yoilsho	5592	11	inhibiting	inhibit	VBG
cord-006229-7yoilsho	5592	12	drug	drug	NN
cord-006229-7yoilsho	5592	13	and	and	CC
cord-006229-7yoilsho	5592	14	of	of	IN
cord-006229-7yoilsho	5592	15	methyl	methyl	NN
cord-006229-7yoilsho	5592	16	methanesulfonate	methanesulfonate	NN
cord-006229-7yoilsho	5592	17	,	,	,
cord-006229-7yoilsho	5592	18	which	which	WDT
cord-006229-7yoilsho	5592	19	forms	form	VBZ
cord-006229-7yoilsho	5592	20	DNA	dna	NN
cord-006229-7yoilsho	5592	21	-	-	HYPH
cord-006229-7yoilsho	5592	22	adducts	adduct	NNS
cord-006229-7yoilsho	5592	23	and	and	CC
cord-006229-7yoilsho	5592	24	stalls	stall	NNS
cord-006229-7yoilsho	5592	25	replication	replication	NN
cord-006229-7yoilsho	5592	26	forks	fork	NNS
cord-006229-7yoilsho	5592	27	,	,	,
cord-006229-7yoilsho	5592	28	were	be	VBD
cord-006229-7yoilsho	5592	29	analyzed	analyze	VBN
cord-006229-7yoilsho	5592	30	.	.	.
cord-006229-7yoilsho	5593	1	In	in	IN
cord-006229-7yoilsho	5593	2	general	general	JJ
cord-006229-7yoilsho	5593	3	,	,	,
cord-006229-7yoilsho	5593	4	a	a	DT
cord-006229-7yoilsho	5593	5	difference	difference	NN
cord-006229-7yoilsho	5593	6	in	in	IN
cord-006229-7yoilsho	5593	7	sensitivity	sensitivity	NN
cord-006229-7yoilsho	5593	8	between	between	IN
cord-006229-7yoilsho	5593	9	the	the	DT
cord-006229-7yoilsho	5593	10	different	different	JJ
cord-006229-7yoilsho	5593	11	substances	substance	NNS
cord-006229-7yoilsho	5593	12	was	be	VBD
cord-006229-7yoilsho	5593	13	observed	observe	VBN
cord-006229-7yoilsho	5593	14	.	.	.
cord-006229-7yoilsho	5594	1	With	with	IN
cord-006229-7yoilsho	5594	2	regard	regard	NN
cord-006229-7yoilsho	5594	3	to	to	IN
cord-006229-7yoilsho	5594	4	the	the	DT
cord-006229-7yoilsho	5594	5	formation	formation	NN
cord-006229-7yoilsho	5594	6	of	of	IN
cord-006229-7yoilsho	5594	7	micronuclei	micronuclei	NNP
cord-006229-7yoilsho	5594	8	after	after	IN
cord-006229-7yoilsho	5594	9	treatment	treatment	NN
cord-006229-7yoilsho	5594	10	with	with	IN
cord-006229-7yoilsho	5594	11	doxorubicin	doxorubicin	NN
cord-006229-7yoilsho	5594	12	,	,	,
cord-006229-7yoilsho	5594	13	Jurkat	Jurkat	NNP
cord-006229-7yoilsho	5594	14	and	and	CC
cord-006229-7yoilsho	5594	15	TK6	TK6	NNP
cord-006229-7yoilsho	5594	16	cells	cell	NNS
cord-006229-7yoilsho	5594	17	showed	show	VBD
cord-006229-7yoilsho	5594	18	similar	similar	JJ
cord-006229-7yoilsho	5594	19	increasing	increasing	JJ
cord-006229-7yoilsho	5594	20	trends	trend	NNS
cord-006229-7yoilsho	5594	21	,	,	,
cord-006229-7yoilsho	5594	22	whereas	whereas	IN
cord-006229-7yoilsho	5594	23	HL60	HL60	NNP
cord-006229-7yoilsho	5594	24	cells	cell	NNS
cord-006229-7yoilsho	5594	25	showed	show	VBD
cord-006229-7yoilsho	5594	26	a	a	DT
cord-006229-7yoilsho	5594	27	much	much	RB
cord-006229-7yoilsho	5594	28	higher	high	JJR
cord-006229-7yoilsho	5594	29	increase	increase	NN
cord-006229-7yoilsho	5594	30	in	in	IN
cord-006229-7yoilsho	5594	31	micronucleus	micronucleus	JJ
cord-006229-7yoilsho	5594	32	frequency	frequency	NN
cord-006229-7yoilsho	5594	33	.	.	.
cord-006229-7yoilsho	5595	1	A	a	DT
cord-006229-7yoilsho	5595	2	clear	clear	JJ
cord-006229-7yoilsho	5595	3	decrease	decrease	NN
cord-006229-7yoilsho	5595	4	in	in	IN
cord-006229-7yoilsho	5595	5	proliferation	proliferation	NN
cord-006229-7yoilsho	5595	6	and	and	CC
cord-006229-7yoilsho	5595	7	the	the	DT
cord-006229-7yoilsho	5595	8	frequency	frequency	NN
cord-006229-7yoilsho	5595	9	of	of	IN
cord-006229-7yoilsho	5595	10	mitotic	mitotic	JJ
cord-006229-7yoilsho	5595	11	cells	cell	NNS
cord-006229-7yoilsho	5595	12	was	be	VBD
cord-006229-7yoilsho	5595	13	observed	observe	VBN
cord-006229-7yoilsho	5595	14	at	at	IN
cord-006229-7yoilsho	5595	15	the	the	DT
cord-006229-7yoilsho	5595	16	highest	high	JJS
cord-006229-7yoilsho	5595	17	concentration	concentration	NN
cord-006229-7yoilsho	5595	18	(	(	-LRB-
cord-006229-7yoilsho	5595	19	100	100	CD
cord-006229-7yoilsho	5595	20	nM	nm	CD
cord-006229-7yoilsho	5595	21	doxorubicin	doxorubicin	NN
cord-006229-7yoilsho	5595	22	)	)	-RRB-
cord-006229-7yoilsho	5595	23	investigated	investigate	VBD
cord-006229-7yoilsho	5595	24	,	,	,
cord-006229-7yoilsho	5595	25	and	and	CC
cord-006229-7yoilsho	5595	26	only	only	RB
cord-006229-7yoilsho	5595	27	a	a	DT
cord-006229-7yoilsho	5595	28	slight	slight	JJ
cord-006229-7yoilsho	5595	29	increase	increase	NN
cord-006229-7yoilsho	5595	30	in	in	IN
cord-006229-7yoilsho	5595	31	the	the	DT
cord-006229-7yoilsho	5595	32	number	number	NN
cord-006229-7yoilsho	5595	33	of	of	IN
cord-006229-7yoilsho	5595	34	apoptotic	apoptotic	JJ
cord-006229-7yoilsho	5595	35	cells	cell	NNS
cord-006229-7yoilsho	5595	36	could	could	MD
cord-006229-7yoilsho	5595	37	be	be	VB
cord-006229-7yoilsho	5595	38	shown	show	VBN
cord-006229-7yoilsho	5595	39	.	.	.
cord-006229-7yoilsho	5596	1	The	the	DT
cord-006229-7yoilsho	5596	2	biggest	big	JJS
cord-006229-7yoilsho	5596	3	differences	difference	NNS
cord-006229-7yoilsho	5596	4	in	in	IN
cord-006229-7yoilsho	5596	5	formation	formation	NN
cord-006229-7yoilsho	5596	6	of	of	IN
cord-006229-7yoilsho	5596	7	micronuclei	micronuclei	NNP
cord-006229-7yoilsho	5596	8	could	could	MD
cord-006229-7yoilsho	5596	9	be	be	VB
cord-006229-7yoilsho	5596	10	detected	detect	VBN
cord-006229-7yoilsho	5596	11	after	after	IN
cord-006229-7yoilsho	5596	12	treatment	treatment	NN
cord-006229-7yoilsho	5596	13	with	with	IN
cord-006229-7yoilsho	5596	14	vinblastine	vinblastine	NN
cord-006229-7yoilsho	5596	15	.	.	.
cord-006229-7yoilsho	5597	1	HL60	HL60	NNP
cord-006229-7yoilsho	5597	2	cells	cell	NNS
cord-006229-7yoilsho	5597	3	showed	show	VBD
cord-006229-7yoilsho	5597	4	only	only	RB
cord-006229-7yoilsho	5597	5	a	a	DT
cord-006229-7yoilsho	5597	6	slight	slight	JJ
cord-006229-7yoilsho	5597	7	increase	increase	NN
cord-006229-7yoilsho	5597	8	of	of	IN
cord-006229-7yoilsho	5597	9	micronuclei	micronuclei	NN
cord-006229-7yoilsho	5597	10	,	,	,
cord-006229-7yoilsho	5597	11	but	but	CC
cord-006229-7yoilsho	5597	12	the	the	DT
cord-006229-7yoilsho	5597	13	effect	effect	NN
cord-006229-7yoilsho	5597	14	on	on	IN
cord-006229-7yoilsho	5597	15	Jurkat	Jurkat	NNP
cord-006229-7yoilsho	5597	16	cells	cell	NNS
cord-006229-7yoilsho	5597	17	was	be	VBD
cord-006229-7yoilsho	5597	18	stronger	strong	JJR
cord-006229-7yoilsho	5597	19	.	.	.
cord-006229-7yoilsho	5598	1	The	the	DT
cord-006229-7yoilsho	5598	2	highest	high	JJS
cord-006229-7yoilsho	5598	3	micronucleus	micronucleus	NN
cord-006229-7yoilsho	5598	4	frequency	frequency	NN
cord-006229-7yoilsho	5598	5	after	after	IN
cord-006229-7yoilsho	5598	6	vinblastine	vinblastine	NN
cord-006229-7yoilsho	5598	7	treatment	treatment	NN
cord-006229-7yoilsho	5598	8	was	be	VBD
cord-006229-7yoilsho	5598	9	detectable	detectable	JJ
cord-006229-7yoilsho	5598	10	for	for	IN
cord-006229-7yoilsho	5598	11	the	the	DT
cord-006229-7yoilsho	5598	12	TK6	TK6	NNP
cord-006229-7yoilsho	5598	13	cells	cell	NNS
cord-006229-7yoilsho	5598	14	.	.	.
cord-006229-7yoilsho	5599	1	The	the	DT
cord-006229-7yoilsho	5599	2	results	result	NNS
cord-006229-7yoilsho	5599	3	for	for	IN
cord-006229-7yoilsho	5599	4	the	the	DT
cord-006229-7yoilsho	5599	5	highest	high	JJS
cord-006229-7yoilsho	5599	6	investigated	investigate	VBN
cord-006229-7yoilsho	5599	7	concentrations	concentration	NNS
cord-006229-7yoilsho	5599	8	(	(	-LRB-
cord-006229-7yoilsho	5599	9	31.6	31.6	CD
cord-006229-7yoilsho	5599	10	nM	nM	NNP
cord-006229-7yoilsho	5599	11	and	and	CC
cord-006229-7yoilsho	5599	12	100	100	CD
cord-006229-7yoilsho	5599	13	nM	nm	CD
cord-006229-7yoilsho	5599	14	vinblastine	vinblastine	NN
cord-006229-7yoilsho	5599	15	)	)	-RRB-
cord-006229-7yoilsho	5599	16	showed	show	VBD
cord-006229-7yoilsho	5599	17	a	a	DT
cord-006229-7yoilsho	5599	18	significant	significant	JJ
cord-006229-7yoilsho	5599	19	reduction	reduction	NN
cord-006229-7yoilsho	5599	20	of	of	IN
cord-006229-7yoilsho	5599	21	the	the	DT
cord-006229-7yoilsho	5599	22	proliferation	proliferation	NN
cord-006229-7yoilsho	5599	23	index	index	NN
cord-006229-7yoilsho	5599	24	.	.	.
cord-006229-7yoilsho	5600	1	This	this	DT
cord-006229-7yoilsho	5600	2	effect	effect	NN
cord-006229-7yoilsho	5600	3	is	be	VBZ
cord-006229-7yoilsho	5600	4	reflected	reflect	VBN
cord-006229-7yoilsho	5600	5	by	by	IN
cord-006229-7yoilsho	5600	6	the	the	DT
cord-006229-7yoilsho	5600	7	increasing	increase	VBG
cord-006229-7yoilsho	5600	8	numbers	number	NNS
cord-006229-7yoilsho	5600	9	of	of	IN
cord-006229-7yoilsho	5600	10	apoptotic	apoptotic	JJ
cord-006229-7yoilsho	5600	11	cells	cell	NNS
cord-006229-7yoilsho	5600	12	in	in	IN
cord-006229-7yoilsho	5600	13	all	all	DT
cord-006229-7yoilsho	5600	14	cell	cell	NN
cord-006229-7yoilsho	5600	15	lines	line	NNS
cord-006229-7yoilsho	5600	16	.	.	.
cord-006229-7yoilsho	5601	1	The	the	DT
cord-006229-7yoilsho	5601	2	results	result	NNS
cord-006229-7yoilsho	5601	3	for	for	IN
cord-006229-7yoilsho	5601	4	methyl	methyl	NN
cord-006229-7yoilsho	5601	5	methanesulfonate	methanesulfonate	NN
cord-006229-7yoilsho	5601	6	demonstrated	demonstrate	VBD
cord-006229-7yoilsho	5601	7	only	only	RB
cord-006229-7yoilsho	5601	8	a	a	DT
cord-006229-7yoilsho	5601	9	small	small	JJ
cord-006229-7yoilsho	5601	10	increase	increase	NN
cord-006229-7yoilsho	5601	11	in	in	IN
cord-006229-7yoilsho	5601	12	micronucleus	micronucleus	NN
cord-006229-7yoilsho	5601	13	formation	formation	NN
cord-006229-7yoilsho	5601	14	for	for	IN
cord-006229-7yoilsho	5601	15	the	the	DT
cord-006229-7yoilsho	5601	16	Jurkat	Jurkat	NNP
cord-006229-7yoilsho	5601	17	cells	cell	NNS
cord-006229-7yoilsho	5601	18	,	,	,
cord-006229-7yoilsho	5601	19	but	but	CC
cord-006229-7yoilsho	5601	20	higher	high	JJR
cord-006229-7yoilsho	5601	21	values	value	NNS
cord-006229-7yoilsho	5601	22	for	for	IN
cord-006229-7yoilsho	5601	23	the	the	DT
cord-006229-7yoilsho	5601	24	TK6	TK6	NNP
cord-006229-7yoilsho	5601	25	cells	cell	NNS
cord-006229-7yoilsho	5601	26	.	.	.
cord-006229-7yoilsho	5602	1	In	in	IN
cord-006229-7yoilsho	5602	2	contrast	contrast	NN
cord-006229-7yoilsho	5602	3	the	the	DT
cord-006229-7yoilsho	5602	4	HL60	HL60	NNP
cord-006229-7yoilsho	5602	5	cells	cell	NNS
cord-006229-7yoilsho	5602	6	did	do	VBD
cord-006229-7yoilsho	5602	7	not	not	RB
cord-006229-7yoilsho	5602	8	lead	lead	VB
cord-006229-7yoilsho	5602	9	to	to	IN
cord-006229-7yoilsho	5602	10	a	a	DT
cord-006229-7yoilsho	5602	11	concentration	concentration	NN
cord-006229-7yoilsho	5602	12	-	-	HYPH
cord-006229-7yoilsho	5602	13	dependent	dependent	JJ
cord-006229-7yoilsho	5602	14	effect	effect	NN
cord-006229-7yoilsho	5602	15	with	with	IN
cord-006229-7yoilsho	5602	16	methyl	methyl	NN
cord-006229-7yoilsho	5602	17	methanesulfonate	methanesulfonate	NN
cord-006229-7yoilsho	5602	18	.	.	.
cord-006229-7yoilsho	5603	1	These	these	DT
cord-006229-7yoilsho	5603	2	results	result	NNS
cord-006229-7yoilsho	5603	3	are	be	VBP
cord-006229-7yoilsho	5603	4	complemented	complement	VBN
cord-006229-7yoilsho	5603	5	by	by	IN
cord-006229-7yoilsho	5603	6	preliminary	preliminary	JJ
cord-006229-7yoilsho	5603	7	findings	finding	NNS
cord-006229-7yoilsho	5603	8	in	in	IN
cord-006229-7yoilsho	5603	9	hematopoietic	hematopoietic	JJ
cord-006229-7yoilsho	5603	10	stem	stem	NN
cord-006229-7yoilsho	5603	11	cells	cell	NNS
cord-006229-7yoilsho	5603	12	at	at	IN
cord-006229-7yoilsho	5603	13	selected	select	VBN
cord-006229-7yoilsho	5603	14	compound	compound	NN
cord-006229-7yoilsho	5603	15	concentrations	concentration	NNS
cord-006229-7yoilsho	5603	16	.	.	.
cord-006229-7yoilsho	5604	1	The	the	DT
cord-006229-7yoilsho	5604	2	different	different	JJ
cord-006229-7yoilsho	5604	3	results	result	NNS
cord-006229-7yoilsho	5604	4	between	between	IN
cord-006229-7yoilsho	5604	5	the	the	DT
cord-006229-7yoilsho	5604	6	leukemia	leukemia	NN
cord-006229-7yoilsho	5604	7	cell	cell	NN
cord-006229-7yoilsho	5604	8	lines	line	NNS
cord-006229-7yoilsho	5604	9	and	and	CC
cord-006229-7yoilsho	5604	10	the	the	DT
cord-006229-7yoilsho	5604	11	stem	stem	NN
cord-006229-7yoilsho	5604	12	cells	cell	NNS
cord-006229-7yoilsho	5604	13	might	may	MD
cord-006229-7yoilsho	5604	14	possibly	possibly	RB
cord-006229-7yoilsho	5604	15	originate	originate	VB
cord-006229-7yoilsho	5604	16	from	from	IN
cord-006229-7yoilsho	5604	17	the	the	DT
cord-006229-7yoilsho	5604	18	different	different	JJ
cord-006229-7yoilsho	5604	19	p53	p53	NN
cord-006229-7yoilsho	5604	20	status	status	NN
cord-006229-7yoilsho	5604	21	of	of	IN
cord-006229-7yoilsho	5604	22	HL60	HL60	NNP
cord-006229-7yoilsho	5604	23	(	(	-LRB-
cord-006229-7yoilsho	5604	24	null	null	JJ
cord-006229-7yoilsho	5604	25	)	)	-RRB-
cord-006229-7yoilsho	5604	26	,	,	,
cord-006229-7yoilsho	5604	27	Jurkat	Jurkat	NNP
cord-006229-7yoilsho	5604	28	(	(	-LRB-
cord-006229-7yoilsho	5604	29	multiple	multiple	JJ
cord-006229-7yoilsho	5604	30	mutations	mutation	NNS
cord-006229-7yoilsho	5604	31	)	)	-RRB-
cord-006229-7yoilsho	5604	32	,	,	,
cord-006229-7yoilsho	5604	33	TK6	TK6	NNP
cord-006229-7yoilsho	5604	34	(	(	-LRB-
cord-006229-7yoilsho	5604	35	wild	wild	JJ
cord-006229-7yoilsho	5604	36	type	type	NN
cord-006229-7yoilsho	5604	37	)	)	-RRB-
cord-006229-7yoilsho	5604	38	and	and	CC
cord-006229-7yoilsho	5604	39	hematopoietic	hematopoietic	JJ
cord-006229-7yoilsho	5604	40	stem	stem	NN
cord-006229-7yoilsho	5604	41	cells	cell	NNS
cord-006229-7yoilsho	5604	42	(	(	-LRB-
cord-006229-7yoilsho	5604	43	wild	wild	JJ
cord-006229-7yoilsho	5604	44	type	type	NN
cord-006229-7yoilsho	5604	45	)	)	-RRB-
cord-006229-7yoilsho	5604	46	.	.	.
cord-006229-7yoilsho	5605	1	This	this	DT
cord-006229-7yoilsho	5605	2	difference	difference	NN
cord-006229-7yoilsho	5605	3	might	may	MD
cord-006229-7yoilsho	5605	4	also	also	RB
cord-006229-7yoilsho	5605	5	cause	cause	VB
cord-006229-7yoilsho	5605	6	differences	difference	NNS
cord-006229-7yoilsho	5605	7	in	in	IN
cord-006229-7yoilsho	5605	8	cell	cell	NN
cord-006229-7yoilsho	5605	9	cycle	cycle	NN
cord-006229-7yoilsho	5605	10	control	control	NN
cord-006229-7yoilsho	5605	11	or	or	CC
cord-006229-7yoilsho	5605	12	repair	repair	NN
cord-006229-7yoilsho	5605	13	mechanisms	mechanism	NNS
cord-006229-7yoilsho	5605	14	,	,	,
cord-006229-7yoilsho	5605	15	and	and	CC
cord-006229-7yoilsho	5605	16	needs	need	VBZ
cord-006229-7yoilsho	5605	17	further	further	JJ
cord-006229-7yoilsho	5605	18	investigations	investigation	NNS
cord-006229-7yoilsho	5605	19	.	.	.
cord-006229-7yoilsho	5606	1	Hyperinsulinemia	Hyperinsulinemia	NNP
cord-006229-7yoilsho	5606	2	is	be	VBZ
cord-006229-7yoilsho	5606	3	thought	think	VBN
cord-006229-7yoilsho	5606	4	to	to	TO
cord-006229-7yoilsho	5606	5	enhance	enhance	VB
cord-006229-7yoilsho	5606	6	cancer	cancer	NN
cord-006229-7yoilsho	5606	7	risk	risk	NN
cord-006229-7yoilsho	5606	8	.	.	.
cord-006229-7yoilsho	5607	1	A	a	DT
cord-006229-7yoilsho	5607	2	possible	possible	JJ
cord-006229-7yoilsho	5607	3	mechanism	mechanism	NN
cord-006229-7yoilsho	5607	4	is	be	VBZ
cord-006229-7yoilsho	5607	5	induction	induction	NN
cord-006229-7yoilsho	5607	6	of	of	IN
cord-006229-7yoilsho	5607	7	oxidative	oxidative	JJ
cord-006229-7yoilsho	5607	8	stress	stress	NN
cord-006229-7yoilsho	5607	9	and	and	CC
cord-006229-7yoilsho	5607	10	DNA	dna	NN
cord-006229-7yoilsho	5607	11	damage	damage	NN
cord-006229-7yoilsho	5607	12	by	by	IN
cord-006229-7yoilsho	5607	13	insulin	insulin	NN
cord-006229-7yoilsho	5607	14	,	,	,
cord-006229-7yoilsho	5607	15	Here	here	RB
cord-006229-7yoilsho	5607	16	,	,	,
cord-006229-7yoilsho	5607	17	the	the	DT
cord-006229-7yoilsho	5607	18	effect	effect	NN
cord-006229-7yoilsho	5607	19	of	of	IN
cord-006229-7yoilsho	5607	20	a	a	DT
cord-006229-7yoilsho	5607	21	combination	combination	NN
cord-006229-7yoilsho	5607	22	of	of	IN
cord-006229-7yoilsho	5607	23	metformin	metformin	NN
cord-006229-7yoilsho	5607	24	with	with	IN
cord-006229-7yoilsho	5607	25	insulin	insulin	NN
cord-006229-7yoilsho	5607	26	was	be	VBD
cord-006229-7yoilsho	5607	27	investigated	investigate	VBN
cord-006229-7yoilsho	5607	28	in	in	IN
cord-006229-7yoilsho	5607	29	vitro	vitro	FW
cord-006229-7yoilsho	5607	30	and	and	CC
cord-006229-7yoilsho	5607	31	in	in	IN
cord-006229-7yoilsho	5607	32	vivo	vivo	NNP
cord-006229-7yoilsho	5607	33	.	.	.
cord-006229-7yoilsho	5608	1	The	the	DT
cord-006229-7yoilsho	5608	2	rational	rational	JJ
cord-006229-7yoilsho	5608	3	for	for	IN
cord-006229-7yoilsho	5608	4	this	this	DT
cord-006229-7yoilsho	5608	5	were	be	VBD
cord-006229-7yoilsho	5608	6	reported	report	VBN
cord-006229-7yoilsho	5608	7	antioxidative	antioxidative	JJ
cord-006229-7yoilsho	5608	8	properties	property	NNS
cord-006229-7yoilsho	5608	9	of	of	IN
cord-006229-7yoilsho	5608	10	metformin	metformin	NNP
cord-006229-7yoilsho	5608	11	and	and	CC
cord-006229-7yoilsho	5608	12	the	the	DT
cord-006229-7yoilsho	5608	13	aim	aim	NN
cord-006229-7yoilsho	5608	14	to	to	TO
cord-006229-7yoilsho	5608	15	gain	gain	VB
cord-006229-7yoilsho	5608	16	further	further	JJ
cord-006229-7yoilsho	5608	17	insights	insight	NNS
cord-006229-7yoilsho	5608	18	into	into	IN
cord-006229-7yoilsho	5608	19	mechanisms	mechanism	NNS
cord-006229-7yoilsho	5608	20	responsible	responsible	JJ
cord-006229-7yoilsho	5608	21	for	for	IN
cord-006229-7yoilsho	5608	22	protecting	protect	VBG
cord-006229-7yoilsho	5608	23	the	the	DT
cord-006229-7yoilsho	5608	24	genome	genome	NN
cord-006229-7yoilsho	5608	25	from	from	IN
cord-006229-7yoilsho	5608	26	insulin	insulin	NN
cord-006229-7yoilsho	5608	27	mediated	mediate	VBN
cord-006229-7yoilsho	5608	28	oxidative	oxidative	JJ
cord-006229-7yoilsho	5608	29	stress	stress	NN
cord-006229-7yoilsho	5608	30	and	and	CC
cord-006229-7yoilsho	5608	31	damage	damage	NN
cord-006229-7yoilsho	5608	32	.	.	.
cord-006229-7yoilsho	5609	1	Comet	comet	NN
cord-006229-7yoilsho	5609	2	assay	assay	NN
cord-006229-7yoilsho	5609	3	,	,	,
cord-006229-7yoilsho	5609	4	micronucleus	micronucleus	NNP
cord-006229-7yoilsho	5609	5	frequency	frequency	NN
cord-006229-7yoilsho	5609	6	test	test	NN
cord-006229-7yoilsho	5609	7	and	and	CC
cord-006229-7yoilsho	5609	8	a	a	DT
cord-006229-7yoilsho	5609	9	mammalian	mammalian	JJ
cord-006229-7yoilsho	5609	10	gene	gene	NN
cord-006229-7yoilsho	5609	11	mutation	mutation	NN
cord-006229-7yoilsho	5609	12	assay	assay	NN
cord-006229-7yoilsho	5609	13	were	be	VBD
cord-006229-7yoilsho	5609	14	used	use	VBN
cord-006229-7yoilsho	5609	15	to	to	TO
cord-006229-7yoilsho	5609	16	evaluate	evaluate	VB
cord-006229-7yoilsho	5609	17	the	the	DT
cord-006229-7yoilsho	5609	18	DNA	dna	NN
cord-006229-7yoilsho	5609	19	damage	damage	NN
cord-006229-7yoilsho	5609	20	produced	produce	VBN
cord-006229-7yoilsho	5609	21	by	by	IN
cord-006229-7yoilsho	5609	22	insulin	insulin	NN
cord-006229-7yoilsho	5609	23	alone	alone	RB
cord-006229-7yoilsho	5609	24	or	or	CC
cord-006229-7yoilsho	5609	25	in	in	IN
cord-006229-7yoilsho	5609	26	combination	combination	NN
cord-006229-7yoilsho	5609	27	with	with	IN
cord-006229-7yoilsho	5609	28	metformin	metformin	NNP
cord-006229-7yoilsho	5609	29	.	.	.
cord-006229-7yoilsho	5610	1	For	for	IN
cord-006229-7yoilsho	5610	2	analysis	analysis	NN
cord-006229-7yoilsho	5610	3	of	of	IN
cord-006229-7yoilsho	5610	4	antioxidant	antioxidant	JJ
cord-006229-7yoilsho	5610	5	activity	activity	NN
cord-006229-7yoilsho	5610	6	,	,	,
cord-006229-7yoilsho	5610	7	oxidative	oxidative	JJ
cord-006229-7yoilsho	5610	8	stress	stress	NN
cord-006229-7yoilsho	5610	9	and	and	CC
cord-006229-7yoilsho	5610	10	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	5610	11	disturbances	disturbance	NNS
cord-006229-7yoilsho	5610	12	,	,	,
cord-006229-7yoilsho	5610	13	the	the	DT
cord-006229-7yoilsho	5610	14	cell	cell	NN
cord-006229-7yoilsho	5610	15	-	-	HYPH
cord-006229-7yoilsho	5610	16	free	free	JJ
cord-006229-7yoilsho	5610	17	FRAP	frap	NN
cord-006229-7yoilsho	5610	18	assay	assay	NN
cord-006229-7yoilsho	5610	19	,	,	,
cord-006229-7yoilsho	5610	20	the	the	DT
cord-006229-7yoilsho	5610	21	superoxide	superoxide	NN
cord-006229-7yoilsho	5610	22	-	-	HYPH
cord-006229-7yoilsho	5610	23	sensitive	sensitive	JJ
cord-006229-7yoilsho	5610	24	dye	dye	NN
cord-006229-7yoilsho	5610	25	dihydroethidium	dihydroethidium	NN
cord-006229-7yoilsho	5610	26	and	and	CC
cord-006229-7yoilsho	5610	27	the	the	DT
cord-006229-7yoilsho	5610	28	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	5610	29	membrane	membrane	NN
cord-006229-7yoilsho	5610	30	potential	potential	JJ
cord-006229-7yoilsho	5610	31	-	-	HYPH
cord-006229-7yoilsho	5610	32	sensitive	sensitive	JJ
cord-006229-7yoilsho	5610	33	dye	dye	NN
cord-006229-7yoilsho	5610	34	JC-1	jc-1	NN
cord-006229-7yoilsho	5610	35	were	be	VBD
cord-006229-7yoilsho	5610	36	applied	apply	VBN
cord-006229-7yoilsho	5610	37	.	.	.
cord-006229-7yoilsho	5611	1	Accumulation	accumulation	NN
cord-006229-7yoilsho	5611	2	of	of	IN
cord-006229-7yoilsho	5611	3	p53	p53	NN
cord-006229-7yoilsho	5611	4	and	and	CC
cord-006229-7yoilsho	5611	5	pAKT	pakt	NN
cord-006229-7yoilsho	5611	6	were	be	VBD
cord-006229-7yoilsho	5611	7	analysed	analyse	VBN
cord-006229-7yoilsho	5611	8	.	.	.
cord-006229-7yoilsho	5612	1	As	as	IN
cord-006229-7yoilsho	5612	2	an	an	DT
cord-006229-7yoilsho	5612	3	in	in	IN
cord-006229-7yoilsho	5612	4	vivo	vivo	NN
cord-006229-7yoilsho	5612	5	model	model	NN
cord-006229-7yoilsho	5612	6	,	,	,
cord-006229-7yoilsho	5612	7	hyperinsulinemic	hyperinsulinemic	JJ
cord-006229-7yoilsho	5612	8	Zucker	Zucker	NNP
cord-006229-7yoilsho	5612	9	Diabetic	diabetic	JJ
cord-006229-7yoilsho	5612	10	Fatty	fatty	JJ
cord-006229-7yoilsho	5612	11	rats	rat	NNS
cord-006229-7yoilsho	5612	12	,	,	,
cord-006229-7yoilsho	5612	13	additionally	additionally	RB
cord-006229-7yoilsho	5612	14	exposed	expose	VBN
cord-006229-7yoilsho	5612	15	to	to	IN
cord-006229-7yoilsho	5612	16	insulin	insulin	NN
cord-006229-7yoilsho	5612	17	during	during	IN
cord-006229-7yoilsho	5612	18	a	a	DT
cord-006229-7yoilsho	5612	19	hyperinsulinemic	hyperinsulinemic	NNP
cord-006229-7yoilsho	5612	20	euglycemic	euglycemic	JJ
cord-006229-7yoilsho	5612	21	clamp	clamp	NN
cord-006229-7yoilsho	5612	22	,	,	,
cord-006229-7yoilsho	5612	23	were	be	VBD
cord-006229-7yoilsho	5612	24	treated	treat	VBN
cord-006229-7yoilsho	5612	25	with	with	IN
cord-006229-7yoilsho	5612	26	metformin	metformin	NNP
cord-006229-7yoilsho	5612	27	.	.	.
cord-006229-7yoilsho	5613	1	In	in	IN
cord-006229-7yoilsho	5613	2	the	the	DT
cord-006229-7yoilsho	5613	3	rat	rat	NN
cord-006229-7yoilsho	5613	4	kidney	kidney	NN
cord-006229-7yoilsho	5613	5	samples	sample	NNS
cord-006229-7yoilsho	5613	6	,	,	,
cord-006229-7yoilsho	5613	7	DHE	DHE	NNP
cord-006229-7yoilsho	5613	8	staining	staining	NN
cord-006229-7yoilsho	5613	9	,	,	,
cord-006229-7yoilsho	5613	10	p53	p53	NN
cord-006229-7yoilsho	5613	11	and	and	CC
cord-006229-7yoilsho	5613	12	pAKT	pakt	NN
cord-006229-7yoilsho	5613	13	analysis	analysis	NN
cord-006229-7yoilsho	5613	14	,	,	,
cord-006229-7yoilsho	5613	15	and	and	CC
cord-006229-7yoilsho	5613	16	quantification	quantification	NN
cord-006229-7yoilsho	5613	17	of	of	IN
cord-006229-7yoilsho	5613	18	the	the	DT
cord-006229-7yoilsho	5613	19	oxidized	oxidize	VBN
cord-006229-7yoilsho	5613	20	DNA	dna	NN
cord-006229-7yoilsho	5613	21	base	base	NN
cord-006229-7yoilsho	5613	22	8-oxodG	8-oxodG	NNP
cord-006229-7yoilsho	5613	23	was	be	VBD
cord-006229-7yoilsho	5613	24	performed	perform	VBN
cord-006229-7yoilsho	5613	25	.	.	.
cord-006229-7yoilsho	5614	1	Metformin	Metformin	NNP
cord-006229-7yoilsho	5614	2	did	do	VBD
cord-006229-7yoilsho	5614	3	not	not	RB
cord-006229-7yoilsho	5614	4	show	show	VB
cord-006229-7yoilsho	5614	5	intrinsic	intrinsic	JJ
cord-006229-7yoilsho	5614	6	antioxidant	antioxidant	JJ
cord-006229-7yoilsho	5614	7	activity	activity	NN
cord-006229-7yoilsho	5614	8	in	in	IN
cord-006229-7yoilsho	5614	9	the	the	DT
cord-006229-7yoilsho	5614	10	cell	cell	NN
cord-006229-7yoilsho	5614	11	free	free	JJ
cord-006229-7yoilsho	5614	12	assay	assay	NN
cord-006229-7yoilsho	5614	13	,	,	,
cord-006229-7yoilsho	5614	14	but	but	CC
cord-006229-7yoilsho	5614	15	protected	protect	VBN
cord-006229-7yoilsho	5614	16	cultured	cultured	JJ
cord-006229-7yoilsho	5614	17	cells	cell	NNS
cord-006229-7yoilsho	5614	18	from	from	IN
cord-006229-7yoilsho	5614	19	insulin	insulin	NN
cord-006229-7yoilsho	5614	20	mediated	mediate	VBN
cord-006229-7yoilsho	5614	21	oxidative	oxidative	JJ
cord-006229-7yoilsho	5614	22	stress	stress	NN
cord-006229-7yoilsho	5614	23	,	,	,
cord-006229-7yoilsho	5614	24	DNA	dna	NN
cord-006229-7yoilsho	5614	25	damage	damage	NN
cord-006229-7yoilsho	5614	26	and	and	CC
cord-006229-7yoilsho	5614	27	mutation	mutation	NN
cord-006229-7yoilsho	5614	28	.	.	.
cord-006229-7yoilsho	5615	1	Treatment	treatment	NN
cord-006229-7yoilsho	5615	2	of	of	IN
cord-006229-7yoilsho	5615	3	the	the	DT
cord-006229-7yoilsho	5615	4	rats	rat	NNS
cord-006229-7yoilsho	5615	5	with	with	IN
cord-006229-7yoilsho	5615	6	metformin	metformin	NNP
cord-006229-7yoilsho	5615	7	protected	protect	VBD
cord-006229-7yoilsho	5615	8	their	-PRON-	PRP$
cord-006229-7yoilsho	5615	9	kidneys	kidney	NNS
cord-006229-7yoilsho	5615	10	from	from	IN
cord-006229-7yoilsho	5615	11	oxidative	oxidative	JJ
cord-006229-7yoilsho	5615	12	stress	stress	NN
cord-006229-7yoilsho	5615	13	and	and	CC
cord-006229-7yoilsho	5615	14	genomic	genomic	JJ
cord-006229-7yoilsho	5615	15	damage	damage	NN
cord-006229-7yoilsho	5615	16	induced	induce	VBN
cord-006229-7yoilsho	5615	17	by	by	IN
cord-006229-7yoilsho	5615	18	hyperinsulinemia	hyperinsulinemia	NN
cord-006229-7yoilsho	5615	19	.	.	.
cord-006229-7yoilsho	5616	1	Metformin	Metformin	NNP
cord-006229-7yoilsho	5616	2	may	may	MD
cord-006229-7yoilsho	5616	3	protect	protect	VB
cord-006229-7yoilsho	5616	4	patients	patient	NNS
cord-006229-7yoilsho	5616	5	from	from	IN
cord-006229-7yoilsho	5616	6	genomic	genomic	JJ
cord-006229-7yoilsho	5616	7	damage	damage	NN
cord-006229-7yoilsho	5616	8	induced	induce	VBN
cord-006229-7yoilsho	5616	9	by	by	IN
cord-006229-7yoilsho	5616	10	elevated	elevated	JJ
cord-006229-7yoilsho	5616	11	insulin	insulin	NN
cord-006229-7yoilsho	5616	12	levels	level	NNS
cord-006229-7yoilsho	5616	13	.	.	.
cord-006229-7yoilsho	5617	1	This	this	DT
cord-006229-7yoilsho	5617	2	may	may	MD
cord-006229-7yoilsho	5617	3	support	support	VB
cord-006229-7yoilsho	5617	4	efforts	effort	NNS
cord-006229-7yoilsho	5617	5	to	to	TO
cord-006229-7yoilsho	5617	6	reduce	reduce	VB
cord-006229-7yoilsho	5617	7	the	the	DT
cord-006229-7yoilsho	5617	8	elevated	elevated	JJ
cord-006229-7yoilsho	5617	9	cancer	cancer	NN
cord-006229-7yoilsho	5617	10	risk	risk	NN
cord-006229-7yoilsho	5617	11	that	that	WDT
cord-006229-7yoilsho	5617	12	is	be	VBZ
cord-006229-7yoilsho	5617	13	associated	associate	VBN
cord-006229-7yoilsho	5617	14	with	with	IN
cord-006229-7yoilsho	5617	15	hyperinsulinemia	hyperinsulinemia	NN
cord-006229-7yoilsho	5617	16	.	.	.
cord-006229-7yoilsho	5618	1	The	the	DT
cord-006229-7yoilsho	5618	2	human	human	JJ
cord-006229-7yoilsho	5618	3	skin	skin	NN
cord-006229-7yoilsho	5618	4	is	be	VBZ
cord-006229-7yoilsho	5618	5	the	the	DT
cord-006229-7yoilsho	5618	6	primary	primary	JJ
cord-006229-7yoilsho	5618	7	barrier	barrier	NN
cord-006229-7yoilsho	5618	8	against	against	IN
cord-006229-7yoilsho	5618	9	environmental	environmental	JJ
cord-006229-7yoilsho	5618	10	and	and	CC
cord-006229-7yoilsho	5618	11	chemical	chemical	JJ
cord-006229-7yoilsho	5618	12	impacts	impact	NNS
cord-006229-7yoilsho	5618	13	.	.	.
cord-006229-7yoilsho	5619	1	As	as	IN
cord-006229-7yoilsho	5619	2	such	such	JJ
cord-006229-7yoilsho	5619	3	it	-PRON-	PRP
cord-006229-7yoilsho	5619	4	shields	shield	VBZ
cord-006229-7yoilsho	5619	5	us	-PRON-	PRP
cord-006229-7yoilsho	5619	6	against	against	IN
cord-006229-7yoilsho	5619	7	a	a	DT
cord-006229-7yoilsho	5619	8	plethora	plethora	NN
cord-006229-7yoilsho	5619	9	of	of	IN
cord-006229-7yoilsho	5619	10	xenobiotics	xenobiotic	NNS
cord-006229-7yoilsho	5619	11	such	such	JJ
cord-006229-7yoilsho	5619	12	as	as	IN
cord-006229-7yoilsho	5619	13	potentially	potentially	RB
cord-006229-7yoilsho	5619	14	carcinogenic	carcinogenic	JJ
cord-006229-7yoilsho	5619	15	polycyclic	polycyclic	JJ
cord-006229-7yoilsho	5619	16	aromatic	aromatic	JJ
cord-006229-7yoilsho	5619	17	hydrocarbons	hydrocarbon	NNS
cord-006229-7yoilsho	5619	18	(	(	-LRB-
cord-006229-7yoilsho	5619	19	PAHs	pah	NNS
cord-006229-7yoilsho	5619	20	)	)	-RRB-
cord-006229-7yoilsho	5619	21	.	.	.
cord-006229-7yoilsho	5620	1	At	at	IN
cord-006229-7yoilsho	5620	2	the	the	DT
cord-006229-7yoilsho	5620	3	same	same	JJ
cord-006229-7yoilsho	5620	4	time	time	NN
cord-006229-7yoilsho	5620	5	it	-PRON-	PRP
cord-006229-7yoilsho	5620	6	is	be	VBZ
cord-006229-7yoilsho	5620	7	the	the	DT
cord-006229-7yoilsho	5620	8	second	second	JJ
cord-006229-7yoilsho	5620	9	most	most	RBS
cord-006229-7yoilsho	5620	10	densely	densely	RB
cord-006229-7yoilsho	5620	11	populated	populate	VBN
cord-006229-7yoilsho	5620	12	organ	organ	NN
cord-006229-7yoilsho	5620	13	,	,	,
cord-006229-7yoilsho	5620	14	harbouring	harbour	VBG
cord-006229-7yoilsho	5620	15	more	more	JJR
cord-006229-7yoilsho	5620	16	than	than	IN
cord-006229-7yoilsho	5620	17	1000	1000	CD
cord-006229-7yoilsho	5620	18	bacterial	bacterial	JJ
cord-006229-7yoilsho	5620	19	species	specie	NNS
cord-006229-7yoilsho	5620	20	and	and	CC
cord-006229-7yoilsho	5620	21	population	population	NN
cord-006229-7yoilsho	5620	22	densities	density	NNS
cord-006229-7yoilsho	5620	23	of	of	IN
cord-006229-7yoilsho	5620	24	up	up	IN
cord-006229-7yoilsho	5620	25	to	to	TO
cord-006229-7yoilsho	5620	26	10	10	CD
cord-006229-7yoilsho	5620	27	7	7	CD
cord-006229-7yoilsho	5620	28	cfu	cfu	NN
cord-006229-7yoilsho	5620	29	per	per	IN
cord-006229-7yoilsho	5620	30	cm	cm	NN
cord-006229-7yoilsho	5620	31	2	2	CD
cord-006229-7yoilsho	5620	32	.	.	.
cord-006229-7yoilsho	5621	1	Yet	yet	CC
cord-006229-7yoilsho	5621	2	little	little	JJ
cord-006229-7yoilsho	5621	3	is	be	VBZ
cord-006229-7yoilsho	5621	4	known	know	VBN
cord-006229-7yoilsho	5621	5	about	about	IN
cord-006229-7yoilsho	5621	6	this	this	DT
cord-006229-7yoilsho	5621	7	microbiome	microbiome	NN
cord-006229-7yoilsho	5621	8	's	's	POS
cord-006229-7yoilsho	5621	9	potential	potential	NN
cord-006229-7yoilsho	5621	10	to	to	TO
cord-006229-7yoilsho	5621	11	metabolise	metabolise	VB
cord-006229-7yoilsho	5621	12	and	and	CC
cord-006229-7yoilsho	5621	13	toxify	toxify	VB
cord-006229-7yoilsho	5621	14	PAHs	pah	NNS
cord-006229-7yoilsho	5621	15	such	such	JJ
cord-006229-7yoilsho	5621	16	as	as	IN
cord-006229-7yoilsho	5621	17	benzo[a]pyrene	benzo[a]pyrene	NN
cord-006229-7yoilsho	5621	18	(	(	-LRB-
cord-006229-7yoilsho	5621	19	B[a]P	B[a]P	NNP
cord-006229-7yoilsho	5621	20	)	)	-RRB-
cord-006229-7yoilsho	5621	21	.	.	.
cord-006229-7yoilsho	5622	1	Previous	previous	JJ
cord-006229-7yoilsho	5622	2	work	work	NN
cord-006229-7yoilsho	5622	3	at	at	IN
cord-006229-7yoilsho	5622	4	the	the	DT
cord-006229-7yoilsho	5622	5	BfR	bfr	NN
cord-006229-7yoilsho	5622	6	showed	show	VBD
cord-006229-7yoilsho	5622	7	that	that	IN
cord-006229-7yoilsho	5622	8	degradation	degradation	NN
cord-006229-7yoilsho	5622	9	of	of	IN
cord-006229-7yoilsho	5622	10	B[a]P	B[a]P	NNS
cord-006229-7yoilsho	5622	11	and	and	CC
cord-006229-7yoilsho	5622	12	other	other	JJ
cord-006229-7yoilsho	5622	13	PAHs	pah	NNS
cord-006229-7yoilsho	5622	14	is	be	VBZ
cord-006229-7yoilsho	5622	15	a	a	DT
cord-006229-7yoilsho	5622	16	universal	universal	JJ
cord-006229-7yoilsho	5622	17	feature	feature	NN
cord-006229-7yoilsho	5622	18	of	of	IN
cord-006229-7yoilsho	5622	19	the	the	DT
cord-006229-7yoilsho	5622	20	skin	skin	NN
cord-006229-7yoilsho	5622	21	's	's	POS
cord-006229-7yoilsho	5622	22	microbiome	microbiome	NN
cord-006229-7yoilsho	5622	23	(	(	-LRB-
cord-006229-7yoilsho	5622	24	Sowada	Sowada	NNP
cord-006229-7yoilsho	5622	25	et	et	NNP
cord-006229-7yoilsho	5622	26	al	al	NNP
cord-006229-7yoilsho	5622	27	.	.	.
cord-006229-7yoilsho	5623	1	,	,	,
cord-006229-7yoilsho	5623	2	2014	2014	CD
cord-006229-7yoilsho	5623	3	)	)	-RRB-
cord-006229-7yoilsho	5623	4	.	.	.
cord-006229-7yoilsho	5624	1	The	the	DT
cord-006229-7yoilsho	5624	2	corresponding	correspond	VBG
cord-006229-7yoilsho	5624	3	metabolites	metabolite	NNS
cord-006229-7yoilsho	5624	4	only	only	RB
cord-006229-7yoilsho	5624	5	partly	partly	RB
cord-006229-7yoilsho	5624	6	overlap	overlap	VBP
cord-006229-7yoilsho	5624	7	with	with	IN
cord-006229-7yoilsho	5624	8	those	those	DT
cord-006229-7yoilsho	5624	9	known	know	VBN
cord-006229-7yoilsho	5624	10	from	from	IN
cord-006229-7yoilsho	5624	11	eukaryotic	eukaryotic	JJ
cord-006229-7yoilsho	5624	12	metabolism	metabolism	NN
cord-006229-7yoilsho	5624	13	and	and	CC
cord-006229-7yoilsho	5624	14	possess	possess	VBP
cord-006229-7yoilsho	5624	15	cytotoxic	cytotoxic	JJ
cord-006229-7yoilsho	5624	16	as	as	RB
cord-006229-7yoilsho	5624	17	well	well	RB
cord-006229-7yoilsho	5624	18	as	as	IN
cord-006229-7yoilsho	5624	19	genotoxic	genotoxic	JJ
cord-006229-7yoilsho	5624	20	properties	property	NNS
cord-006229-7yoilsho	5624	21	.	.	.
cord-006229-7yoilsho	5625	1	Excretion	excretion	NN
cord-006229-7yoilsho	5625	2	of	of	IN
cord-006229-7yoilsho	5625	3	these	these	DT
cord-006229-7yoilsho	5625	4	metabolites	metabolite	NNS
cord-006229-7yoilsho	5625	5	will	will	MD
cord-006229-7yoilsho	5625	6	lead	lead	VB
cord-006229-7yoilsho	5625	7	to	to	IN
cord-006229-7yoilsho	5625	8	exposure	exposure	NN
cord-006229-7yoilsho	5625	9	times	time	NNS
cord-006229-7yoilsho	5625	10	of	of	IN
cord-006229-7yoilsho	5625	11	20	20	CD
cord-006229-7yoilsho	5625	12	-	-	SYM
cord-006229-7yoilsho	5625	13	30	30	CD
cord-006229-7yoilsho	5625	14	hours	hour	NNS
cord-006229-7yoilsho	5625	15	or	or	CC
cord-006229-7yoilsho	5625	16	longer	long	JJR
cord-006229-7yoilsho	5625	17	for	for	IN
cord-006229-7yoilsho	5625	18	full	full	JJ
cord-006229-7yoilsho	5625	19	and	and	CC
cord-006229-7yoilsho	5625	20	partial	partial	JJ
cord-006229-7yoilsho	5625	21	metabolisers	metaboliser	NNS
cord-006229-7yoilsho	5625	22	,	,	,
cord-006229-7yoilsho	5625	23	respectively	respectively	RB
cord-006229-7yoilsho	5625	24	.	.	.
cord-006229-7yoilsho	5626	1	While	while	IN
cord-006229-7yoilsho	5626	2	in	in	FW
cord-006229-7yoilsho	5626	3	vitro	vitro	FW
cord-006229-7yoilsho	5626	4	studies	study	NNS
cord-006229-7yoilsho	5626	5	show	show	VBP
cord-006229-7yoilsho	5626	6	the	the	DT
cord-006229-7yoilsho	5626	7	corresponding	correspond	VBG
cord-006229-7yoilsho	5626	8	substances	substance	NNS
cord-006229-7yoilsho	5626	9	to	to	TO
cord-006229-7yoilsho	5626	10	exert	exert	VB
cord-006229-7yoilsho	5626	11	their	-PRON-	PRP$
cord-006229-7yoilsho	5626	12	effects	effect	NNS
cord-006229-7yoilsho	5626	13	synergistically	synergistically	RB
cord-006229-7yoilsho	5626	14	,	,	,
cord-006229-7yoilsho	5626	15	an	an	DT
cord-006229-7yoilsho	5626	16	assessment	assessment	NN
cord-006229-7yoilsho	5626	17	of	of	IN
cord-006229-7yoilsho	5626	18	their	-PRON-	PRP$
cord-006229-7yoilsho	5626	19	potential	potential	JJ
cord-006229-7yoilsho	5626	20	impact	impact	NN
cord-006229-7yoilsho	5626	21	on	on	IN
cord-006229-7yoilsho	5626	22	human	human	JJ
cord-006229-7yoilsho	5626	23	carcinogenesis	carcinogenesis	NN
cord-006229-7yoilsho	5626	24	is	be	VBZ
cord-006229-7yoilsho	5626	25	pending	pende	VBG
cord-006229-7yoilsho	5626	26	.	.	.
cord-006229-7yoilsho	5627	1	One	one	CD
cord-006229-7yoilsho	5627	2	obvious	obvious	JJ
cord-006229-7yoilsho	5627	3	mode	mode	NN
cord-006229-7yoilsho	5627	4	of	of	IN
cord-006229-7yoilsho	5627	5	action	action	NN
cord-006229-7yoilsho	5627	6	would	would	MD
cord-006229-7yoilsho	5627	7	be	be	VB
cord-006229-7yoilsho	5627	8	direct	direct	JJ
cord-006229-7yoilsho	5627	9	genotoxicity	genotoxicity	NN
cord-006229-7yoilsho	5627	10	.	.	.
cord-006229-7yoilsho	5628	1	However	however	RB
cord-006229-7yoilsho	5628	2	,	,	,
cord-006229-7yoilsho	5628	3	another	another	DT
cord-006229-7yoilsho	5628	4	option	option	NN
cord-006229-7yoilsho	5628	5	is	be	VBZ
cord-006229-7yoilsho	5628	6	interference	interference	NN
cord-006229-7yoilsho	5628	7	with	with	IN
cord-006229-7yoilsho	5628	8	UV	uv	NN
cord-006229-7yoilsho	5628	9	-	-	HYPH
cord-006229-7yoilsho	5628	10	damage	damage	NN
cord-006229-7yoilsho	5628	11	repair	repair	NN
cord-006229-7yoilsho	5628	12	.	.	.
cord-006229-7yoilsho	5629	1	Ultraviolet	ultraviolet	NN
cord-006229-7yoilsho	5629	2	radiation	radiation	NN
cord-006229-7yoilsho	5629	3	(	(	-LRB-
cord-006229-7yoilsho	5629	4	UVR	UVR	NNP
cord-006229-7yoilsho	5629	5	)	)	-RRB-
cord-006229-7yoilsho	5629	6	from	from	IN
cord-006229-7yoilsho	5629	7	sunlight	sunlight	NN
cord-006229-7yoilsho	5629	8	is	be	VBZ
cord-006229-7yoilsho	5629	9	regarded	regard	VBN
cord-006229-7yoilsho	5629	10	the	the	DT
cord-006229-7yoilsho	5629	11	main	main	JJ
cord-006229-7yoilsho	5629	12	causative	causative	JJ
cord-006229-7yoilsho	5629	13	factor	factor	NN
cord-006229-7yoilsho	5629	14	for	for	IN
cord-006229-7yoilsho	5629	15	the	the	DT
cord-006229-7yoilsho	5629	16	induction	induction	NN
cord-006229-7yoilsho	5629	17	of	of	IN
cord-006229-7yoilsho	5629	18	skin	skin	NN
cord-006229-7yoilsho	5629	19	cancer	cancer	NN
cord-006229-7yoilsho	5629	20	.	.	.
cord-006229-7yoilsho	5630	1	It	-PRON-	PRP
cord-006229-7yoilsho	5630	2	induces	induce	VBZ
cord-006229-7yoilsho	5630	3	two	two	CD
cord-006229-7yoilsho	5630	4	of	of	IN
cord-006229-7yoilsho	5630	5	the	the	DT
cord-006229-7yoilsho	5630	6	most	most	RBS
cord-006229-7yoilsho	5630	7	abundant	abundant	JJ
cord-006229-7yoilsho	5630	8	mutagenic	mutagenic	JJ
cord-006229-7yoilsho	5630	9	and	and	CC
cord-006229-7yoilsho	5630	10	cytotoxic	cytotoxic	JJ
cord-006229-7yoilsho	5630	11	DNA	dna	NN
cord-006229-7yoilsho	5630	12	lesions	lesion	NNS
cord-006229-7yoilsho	5630	13	,	,	,
cord-006229-7yoilsho	5630	14	that	that	RB
cord-006229-7yoilsho	5630	15	is	is	RB
cord-006229-7yoilsho	5630	16	cyclobutane	cyclobutane	NN
cord-006229-7yoilsho	5630	17	-	-	HYPH
cord-006229-7yoilsho	5630	18	pyrimidine	pyrimidine	NN
cord-006229-7yoilsho	5630	19	dimers	dimer	NNS
cord-006229-7yoilsho	5630	20	(	(	-LRB-
cord-006229-7yoilsho	5630	21	CPDs	cpd	NNS
cord-006229-7yoilsho	5630	22	)	)	-RRB-
cord-006229-7yoilsho	5630	23	and	and	CC
cord-006229-7yoilsho	5630	24	6	6	CD
cord-006229-7yoilsho	5630	25	-	-	SYM
cord-006229-7yoilsho	5630	26	4	4	CD
cord-006229-7yoilsho	5630	27	photoproducts	photoproduct	NNS
cord-006229-7yoilsho	5630	28	(	(	-LRB-
cord-006229-7yoilsho	5630	29	6	6	CD
cord-006229-7yoilsho	5630	30	-	-	SYM
cord-006229-7yoilsho	5630	31	4PPs	4pps	CD
cord-006229-7yoilsho	5630	32	)	)	-RRB-
cord-006229-7yoilsho	5630	33	.	.	.
cord-006229-7yoilsho	5631	1	These	these	DT
cord-006229-7yoilsho	5631	2	lesions	lesion	NNS
cord-006229-7yoilsho	5631	3	are	be	VBP
cord-006229-7yoilsho	5631	4	repaired	repair	VBN
cord-006229-7yoilsho	5631	5	primarily	primarily	RB
cord-006229-7yoilsho	5631	6	by	by	IN
cord-006229-7yoilsho	5631	7	nucleotide	nucleotide	JJ
cord-006229-7yoilsho	5631	8	excision	excision	NN
cord-006229-7yoilsho	5631	9	repair	repair	NN
cord-006229-7yoilsho	5631	10	(	(	-LRB-
cord-006229-7yoilsho	5631	11	NER	NER	NNP
cord-006229-7yoilsho	5631	12	)	)	-RRB-
cord-006229-7yoilsho	5631	13	,	,	,
cord-006229-7yoilsho	5631	14	a	a	DT
cord-006229-7yoilsho	5631	15	system	system	NN
cord-006229-7yoilsho	5631	16	that	that	WDT
cord-006229-7yoilsho	5631	17	is	be	VBZ
cord-006229-7yoilsho	5631	18	also	also	RB
cord-006229-7yoilsho	5631	19	responsible	responsible	JJ
cord-006229-7yoilsho	5631	20	for	for	IN
cord-006229-7yoilsho	5631	21	the	the	DT
cord-006229-7yoilsho	5631	22	removal	removal	NN
cord-006229-7yoilsho	5631	23	of	of	IN
cord-006229-7yoilsho	5631	24	PAH	PAH	NNP
cord-006229-7yoilsho	5631	25	-	-	HYPH
cord-006229-7yoilsho	5631	26	derived	derive	VBN
cord-006229-7yoilsho	5631	27	DNA	dna	NN
cord-006229-7yoilsho	5631	28	adducts	adduct	NNS
cord-006229-7yoilsho	5631	29	.	.	.
cord-006229-7yoilsho	5632	1	We	-PRON-	PRP
cord-006229-7yoilsho	5632	2	therefore	therefore	RB
cord-006229-7yoilsho	5632	3	wanted	want	VBD
cord-006229-7yoilsho	5632	4	to	to	TO
cord-006229-7yoilsho	5632	5	know	know	VB
cord-006229-7yoilsho	5632	6	whether	whether	IN
cord-006229-7yoilsho	5632	7	and	and	CC
cord-006229-7yoilsho	5632	8	to	to	TO
cord-006229-7yoilsho	5632	9	what	what	WDT
cord-006229-7yoilsho	5632	10	extent	extent	NN
cord-006229-7yoilsho	5632	11	bacterial	bacterial	JJ
cord-006229-7yoilsho	5632	12	B[a]P	B[a]P	.
cord-006229-7yoilsho	5632	13	metabolites	metabolite	NNS
cord-006229-7yoilsho	5632	14	have	have	VBP
cord-006229-7yoilsho	5632	15	the	the	DT
cord-006229-7yoilsho	5632	16	capacity	capacity	NN
cord-006229-7yoilsho	5632	17	to	to	TO
cord-006229-7yoilsho	5632	18	interfere	interfere	VB
cord-006229-7yoilsho	5632	19	with	with	IN
cord-006229-7yoilsho	5632	20	NER	NER	NNP
cord-006229-7yoilsho	5632	21	,	,	,
cord-006229-7yoilsho	5632	22	potentially	potentially	RB
cord-006229-7yoilsho	5632	23	contributing	contribute	VBG
cord-006229-7yoilsho	5632	24	to	to	IN
cord-006229-7yoilsho	5632	25	UV	uv	NN
cord-006229-7yoilsho	5632	26	-	-	HYPH
cord-006229-7yoilsho	5632	27	induced	induce	VBN
cord-006229-7yoilsho	5632	28	DNA	dna	NN
cord-006229-7yoilsho	5632	29	-	-	HYPH
cord-006229-7yoilsho	5632	30	damage	damage	NN
cord-006229-7yoilsho	5632	31	.	.	.
cord-006229-7yoilsho	5633	1	To	to	TO
cord-006229-7yoilsho	5633	2	investigate	investigate	VB
cord-006229-7yoilsho	5633	3	this	this	DT
cord-006229-7yoilsho	5633	4	selected	select	VBN
cord-006229-7yoilsho	5633	5	genotoxic	genotoxic	JJ
cord-006229-7yoilsho	5633	6	metabolites	metabolite	NNS
cord-006229-7yoilsho	5633	7	were	be	VBD
cord-006229-7yoilsho	5633	8	examined	examine	VBN
cord-006229-7yoilsho	5633	9	for	for	IN
cord-006229-7yoilsho	5633	10	their	-PRON-	PRP$
cord-006229-7yoilsho	5633	11	potential	potential	NN
cord-006229-7yoilsho	5633	12	to	to	TO
cord-006229-7yoilsho	5633	13	affect	affect	VB
cord-006229-7yoilsho	5633	14	the	the	DT
cord-006229-7yoilsho	5633	15	DNA	dna	NN
cord-006229-7yoilsho	5633	16	repair	repair	NN
cord-006229-7yoilsho	5633	17	capacity	capacity	NN
cord-006229-7yoilsho	5633	18	of	of	IN
cord-006229-7yoilsho	5633	19	skin	skin	NN
cord-006229-7yoilsho	5633	20	cells	cell	NNS
cord-006229-7yoilsho	5633	21	(	(	-LRB-
cord-006229-7yoilsho	5633	22	HaCaT	HaCaT	NNP
cord-006229-7yoilsho	5633	23	)	)	-RRB-
cord-006229-7yoilsho	5633	24	.	.	.
cord-006229-7yoilsho	5634	1	Following	follow	VBG
cord-006229-7yoilsho	5634	2	treatment	treatment	NN
cord-006229-7yoilsho	5634	3	with	with	IN
cord-006229-7yoilsho	5634	4	UVA	UVA	NNP
cord-006229-7yoilsho	5634	5	/	/	SYM
cord-006229-7yoilsho	5634	6	B	b	NN
cord-006229-7yoilsho	5634	7	and	and	CC
cord-006229-7yoilsho	5634	8	bacterial	bacterial	JJ
cord-006229-7yoilsho	5634	9	B[a]P	B[a]P	NNS
cord-006229-7yoilsho	5634	10	-	-	HYPH
cord-006229-7yoilsho	5634	11	metabolites	metabolite	NNS
cord-006229-7yoilsho	5634	12	the	the	DT
cord-006229-7yoilsho	5634	13	skin	skin	NN
cord-006229-7yoilsho	5634	14	's	's	POS
cord-006229-7yoilsho	5634	15	repair	repair	NN
cord-006229-7yoilsho	5634	16	capacity	capacity	NN
cord-006229-7yoilsho	5634	17	was	be	VBD
cord-006229-7yoilsho	5634	18	assessed	assess	VBN
cord-006229-7yoilsho	5634	19	using	use	VBG
cord-006229-7yoilsho	5634	20	a	a	DT
cord-006229-7yoilsho	5634	21	modified	modify	VBN
cord-006229-7yoilsho	5634	22	COMET	comet	NN
cord-006229-7yoilsho	5634	23	-	-	HYPH
cord-006229-7yoilsho	5634	24	Assay	Assay	NNP
cord-006229-7yoilsho	5634	25	.	.	.
cord-006229-7yoilsho	5635	1	Ionizing	Ionizing	NNP
cord-006229-7yoilsho	5635	2	Radiation	Radiation	NNP
cord-006229-7yoilsho	5635	3	(	(	-LRB-
cord-006229-7yoilsho	5635	4	IR	IR	NNP
cord-006229-7yoilsho	5635	5	)	)	-RRB-
cord-006229-7yoilsho	5635	6	is	be	VBZ
cord-006229-7yoilsho	5635	7	a	a	DT
cord-006229-7yoilsho	5635	8	well	well	RB
cord-006229-7yoilsho	5635	9	-	-	HYPH
cord-006229-7yoilsho	5635	10	established	establish	VBN
cord-006229-7yoilsho	5635	11	model	model	NN
cord-006229-7yoilsho	5635	12	to	to	TO
cord-006229-7yoilsho	5635	13	induce	induce	VB
cord-006229-7yoilsho	5635	14	DNA	DNA	NNP
cord-006229-7yoilsho	5635	15	double	double	JJ
cord-006229-7yoilsho	5635	16	-	-	HYPH
cord-006229-7yoilsho	5635	17	strand	strand	NN
cord-006229-7yoilsho	5635	18	breaks	break	NNS
cord-006229-7yoilsho	5635	19	(	(	-LRB-
cord-006229-7yoilsho	5635	20	DNA	dna	NN
cord-006229-7yoilsho	5635	21	-	-	HYPH
cord-006229-7yoilsho	5635	22	DSBs	dsb	NNS
cord-006229-7yoilsho	5635	23	)	)	-RRB-
cord-006229-7yoilsho	5635	24	,	,	,
cord-006229-7yoilsho	5635	25	but	but	CC
cord-006229-7yoilsho	5635	26	it	-PRON-	PRP
cord-006229-7yoilsho	5635	27	also	also	RB
cord-006229-7yoilsho	5635	28	generates	generate	VBZ
cord-006229-7yoilsho	5635	29	a	a	DT
cord-006229-7yoilsho	5635	30	broad	broad	JJ
cord-006229-7yoilsho	5635	31	range	range	NN
cord-006229-7yoilsho	5635	32	of	of	IN
cord-006229-7yoilsho	5635	33	other	other	JJ
cord-006229-7yoilsho	5635	34	DNA	dna	NN
cord-006229-7yoilsho	5635	35	lesions	lesion	NNS
cord-006229-7yoilsho	5635	36	including	include	VBG
cord-006229-7yoilsho	5635	37	DNA	DNA	NNP
cord-006229-7yoilsho	5635	38	single	single	JJ
cord-006229-7yoilsho	5635	39	-	-	HYPH
cord-006229-7yoilsho	5635	40	strand	strand	NN
cord-006229-7yoilsho	5635	41	breaks	break	NNS
cord-006229-7yoilsho	5635	42	as	as	RB
cord-006229-7yoilsho	5635	43	well	well	RB
cord-006229-7yoilsho	5635	44	as	as	IN
cord-006229-7yoilsho	5635	45	oxidative	oxidative	JJ
cord-006229-7yoilsho	5635	46	DNA	dna	NN
cord-006229-7yoilsho	5635	47	base	base	NN
cord-006229-7yoilsho	5635	48	modifications	modification	NNS
cord-006229-7yoilsho	5635	49	.	.	.
cord-006229-7yoilsho	5636	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	5636	2	,	,	,
cord-006229-7yoilsho	5636	3	IR	IR	NNP
cord-006229-7yoilsho	5636	4	is	be	VBZ
cord-006229-7yoilsho	5636	5	able	able	JJ
cord-006229-7yoilsho	5636	6	to	to	TO
cord-006229-7yoilsho	5636	7	modify	modify	VB
cord-006229-7yoilsho	5636	8	membrane	membrane	NN
cord-006229-7yoilsho	5636	9	components	component	NNS
cord-006229-7yoilsho	5636	10	and	and	CC
cord-006229-7yoilsho	5636	11	triggers	trigger	VBZ
cord-006229-7yoilsho	5636	12	the	the	DT
cord-006229-7yoilsho	5636	13	activation	activation	NN
cord-006229-7yoilsho	5636	14	of	of	IN
cord-006229-7yoilsho	5636	15	epidermal	epidermal	JJ
cord-006229-7yoilsho	5636	16	growth	growth	NN
cord-006229-7yoilsho	5636	17	factor	factor	NN
cord-006229-7yoilsho	5636	18	receptor	receptor	NN
cord-006229-7yoilsho	5636	19	.	.	.
cord-006229-7yoilsho	5637	1	A	a	DT
cord-006229-7yoilsho	5637	2	more	more	RBR
cord-006229-7yoilsho	5637	3	specific	specific	JJ
cord-006229-7yoilsho	5637	4	DSB	DSB	NNP
cord-006229-7yoilsho	5637	5	-	-	HYPH
cord-006229-7yoilsho	5637	6	inducer	inducer	NN
cord-006229-7yoilsho	5637	7	is	be	VBZ
cord-006229-7yoilsho	5637	8	cytolethal	cytolethal	NN
cord-006229-7yoilsho	5637	9	distending	distend	VBG
cord-006229-7yoilsho	5637	10	toxin	toxin	NN
cord-006229-7yoilsho	5637	11	(	(	-LRB-
cord-006229-7yoilsho	5637	12	CDT	CDT	NNP
cord-006229-7yoilsho	5637	13	)	)	-RRB-
cord-006229-7yoilsho	5637	14	,	,	,
cord-006229-7yoilsho	5637	15	which	which	WDT
cord-006229-7yoilsho	5637	16	is	be	VBZ
cord-006229-7yoilsho	5637	17	produced	produce	VBN
cord-006229-7yoilsho	5637	18	by	by	IN
cord-006229-7yoilsho	5637	19	a	a	DT
cord-006229-7yoilsho	5637	20	variety	variety	NN
cord-006229-7yoilsho	5637	21	of	of	IN
cord-006229-7yoilsho	5637	22	gram	gram	NN
cord-006229-7yoilsho	5637	23	-	-	HYPH
cord-006229-7yoilsho	5637	24	negative	negative	JJ
cord-006229-7yoilsho	5637	25	bacteria	bacteria	NNS
cord-006229-7yoilsho	5637	26	and	and	CC
cord-006229-7yoilsho	5637	27	harbours	harbour	VBZ
cord-006229-7yoilsho	5637	28	an	an	DT
cord-006229-7yoilsho	5637	29	intrinsic	intrinsic	JJ
cord-006229-7yoilsho	5637	30	DNase	DNase	NNP
cord-006229-7yoilsho	5637	31	-	-	HYPH
cord-006229-7yoilsho	5637	32	like	like	JJ
cord-006229-7yoilsho	5637	33	endonuclease	endonuclease	NN
cord-006229-7yoilsho	5637	34	activity	activity	NN
cord-006229-7yoilsho	5637	35	[	[	-LRB-
cord-006229-7yoilsho	5637	36	1	1	CD
cord-006229-7yoilsho	5637	37	]	]	-RRB-
cord-006229-7yoilsho	5637	38	.	.	.
cord-006229-7yoilsho	5638	1	DSBs	dsb	NNS
cord-006229-7yoilsho	5638	2	are	be	VBP
cord-006229-7yoilsho	5638	3	potent	potent	JJ
cord-006229-7yoilsho	5638	4	cytotoxic	cytotoxic	JJ
cord-006229-7yoilsho	5638	5	lesions	lesion	NNS
cord-006229-7yoilsho	5638	6	and	and	CC
cord-006229-7yoilsho	5638	7	promote	promote	VB
cord-006229-7yoilsho	5638	8	genomic	genomic	JJ
cord-006229-7yoilsho	5638	9	instability	instability	NN
cord-006229-7yoilsho	5638	10	,	,	,
cord-006229-7yoilsho	5638	11	e.g.	e.g.	RB
cord-006229-7yoilsho	5638	12	by	by	IN
cord-006229-7yoilsho	5638	13	formation	formation	NN
cord-006229-7yoilsho	5638	14	of	of	IN
cord-006229-7yoilsho	5638	15	chromosomal	chromosomal	JJ
cord-006229-7yoilsho	5638	16	aberrations	aberration	NNS
cord-006229-7yoilsho	5638	17	.	.	.
cord-006229-7yoilsho	5639	1	A	a	DT
cord-006229-7yoilsho	5639	2	cellular	cellular	JJ
cord-006229-7yoilsho	5639	3	mechanism	mechanism	NN
cord-006229-7yoilsho	5639	4	to	to	TO
cord-006229-7yoilsho	5639	5	prevent	prevent	VB
cord-006229-7yoilsho	5639	6	genomic	genomic	JJ
cord-006229-7yoilsho	5639	7	instability	instability	NN
cord-006229-7yoilsho	5639	8	and	and	CC
cord-006229-7yoilsho	5639	9	maintain	maintain	VB
cord-006229-7yoilsho	5639	10	cell	cell	NN
cord-006229-7yoilsho	5639	11	homeostasis	homeostasis	NN
cord-006229-7yoilsho	5639	12	could	could	MD
cord-006229-7yoilsho	5639	13	be	be	VB
cord-006229-7yoilsho	5639	14	autophagy	autophagy	NN
cord-006229-7yoilsho	5639	15	.	.	.
cord-006229-7yoilsho	5640	1	This	this	DT
cord-006229-7yoilsho	5640	2	process	process	NN
cord-006229-7yoilsho	5640	3	is	be	VBZ
cord-006229-7yoilsho	5640	4	highly	highly	RB
cord-006229-7yoilsho	5640	5	regulated	regulated	JJ
cord-006229-7yoilsho	5640	6	involving	involve	VBG
cord-006229-7yoilsho	5640	7	the	the	DT
cord-006229-7yoilsho	5640	8	lysosomal	lysosomal	JJ
cord-006229-7yoilsho	5640	9	degradation	degradation	NN
cord-006229-7yoilsho	5640	10	of	of	IN
cord-006229-7yoilsho	5640	11	damaged	damaged	JJ
cord-006229-7yoilsho	5640	12	organelles	organelle	NNS
cord-006229-7yoilsho	5640	13	and	and	CC
cord-006229-7yoilsho	5640	14	proteins	protein	NNS
cord-006229-7yoilsho	5640	15	.	.	.
cord-006229-7yoilsho	5641	1	Here	here	RB
cord-006229-7yoilsho	5641	2	,	,	,
cord-006229-7yoilsho	5641	3	we	-PRON-	PRP
cord-006229-7yoilsho	5641	4	study	study	VBP
cord-006229-7yoilsho	5641	5	autophagy	autophagy	NN
cord-006229-7yoilsho	5641	6	induction	induction	NN
cord-006229-7yoilsho	5641	7	following	follow	VBG
cord-006229-7yoilsho	5641	8	DSB	DSB	NNP
cord-006229-7yoilsho	5641	9	generation	generation	NN
cord-006229-7yoilsho	5641	10	in	in	IN
cord-006229-7yoilsho	5641	11	human	human	JJ
cord-006229-7yoilsho	5641	12	colorectal	colorectal	JJ
cord-006229-7yoilsho	5641	13	cancer	cancer	NN
cord-006229-7yoilsho	5641	14	cells	cell	NNS
cord-006229-7yoilsho	5641	15	as	as	RB
cord-006229-7yoilsho	5641	16	well	well	RB
cord-006229-7yoilsho	5641	17	as	as	IN
cord-006229-7yoilsho	5641	18	in	in	IN
cord-006229-7yoilsho	5641	19	primary	primary	JJ
cord-006229-7yoilsho	5641	20	human	human	JJ
cord-006229-7yoilsho	5641	21	colonic	colonic	JJ
cord-006229-7yoilsho	5641	22	epithelial	epithelial	JJ
cord-006229-7yoilsho	5641	23	cells	cell	NNS
cord-006229-7yoilsho	5641	24	(	(	-LRB-
cord-006229-7yoilsho	5641	25	HCEC	HCEC	NNP
cord-006229-7yoilsho	5641	26	)	)	-RRB-
cord-006229-7yoilsho	5641	27	and	and	CC
cord-006229-7yoilsho	5641	28	analyzed	analyze	VBD
cord-006229-7yoilsho	5641	29	regulatory	regulatory	JJ
cord-006229-7yoilsho	5641	30	mechanisms	mechanism	NNS
cord-006229-7yoilsho	5641	31	.	.	.
cord-006229-7yoilsho	5642	1	First	first	RB
cord-006229-7yoilsho	5642	2	,	,	,
cord-006229-7yoilsho	5642	3	the	the	DT
cord-006229-7yoilsho	5642	4	autophagy	autophagy	NN
cord-006229-7yoilsho	5642	5	-	-	HYPH
cord-006229-7yoilsho	5642	6	specific	specific	JJ
cord-006229-7yoilsho	5642	7	marker	marker	NN
cord-006229-7yoilsho	5642	8	LC3B	LC3B	''
cord-006229-7yoilsho	5642	9	was	be	VBD
cord-006229-7yoilsho	5642	10	shown	show	VBN
cord-006229-7yoilsho	5642	11	to	to	TO
cord-006229-7yoilsho	5642	12	increase	increase	VB
cord-006229-7yoilsho	5642	13	in	in	IN
cord-006229-7yoilsho	5642	14	a	a	DT
cord-006229-7yoilsho	5642	15	dose	dose	NN
cord-006229-7yoilsho	5642	16	-	-	HYPH
cord-006229-7yoilsho	5642	17	and	and	CC
cord-006229-7yoilsho	5642	18	time	time	NN
cord-006229-7yoilsho	5642	19	-	-	HYPH
cord-006229-7yoilsho	5642	20	dependent	dependent	JJ
cord-006229-7yoilsho	5642	21	manner	manner	NN
cord-006229-7yoilsho	5642	22	after	after	IN
cord-006229-7yoilsho	5642	23	treatment	treatment	NN
cord-006229-7yoilsho	5642	24	with	with	IN
cord-006229-7yoilsho	5642	25	both	both	CC
cord-006229-7yoilsho	5642	26	CDT	CDT	NNP
cord-006229-7yoilsho	5642	27	and	and	CC
cord-006229-7yoilsho	5642	28	IR	IR	NNP
cord-006229-7yoilsho	5642	29	as	as	IN
cord-006229-7yoilsho	5642	30	assessed	assess	VBN
cord-006229-7yoilsho	5642	31	by	by	IN
cord-006229-7yoilsho	5642	32	confocal	confocal	JJ
cord-006229-7yoilsho	5642	33	immunofluorescence	immunofluorescence	NN
cord-006229-7yoilsho	5642	34	microscopy	microscopy	NN
cord-006229-7yoilsho	5642	35	and	and	CC
cord-006229-7yoilsho	5642	36	Western	western	JJ
cord-006229-7yoilsho	5642	37	blot	blot	NN
cord-006229-7yoilsho	5642	38	analysis	analysis	NN
cord-006229-7yoilsho	5642	39	in	in	IN
cord-006229-7yoilsho	5642	40	HCT116	HCT116	NNP
cord-006229-7yoilsho	5642	41	.	.	.
cord-006229-7yoilsho	5643	1	Similar	similar	JJ
cord-006229-7yoilsho	5643	2	results	result	NNS
cord-006229-7yoilsho	5643	3	were	be	VBD
cord-006229-7yoilsho	5643	4	obtained	obtain	VBN
cord-006229-7yoilsho	5643	5	in	in	IN
cord-006229-7yoilsho	5643	6	SW48	SW48	NNP
cord-006229-7yoilsho	5643	7	and	and	CC
cord-006229-7yoilsho	5643	8	HCEC	HCEC	NNP
cord-006229-7yoilsho	5643	9	cells	cell	NNS
cord-006229-7yoilsho	5643	10	via	via	IN
cord-006229-7yoilsho	5643	11	Western	western	JJ
cord-006229-7yoilsho	5643	12	blot	blot	NN
cord-006229-7yoilsho	5643	13	.	.	.
cord-006229-7yoilsho	5644	1	These	these	DT
cord-006229-7yoilsho	5644	2	findings	finding	NNS
cord-006229-7yoilsho	5644	3	are	be	VBP
cord-006229-7yoilsho	5644	4	in	in	IN
cord-006229-7yoilsho	5644	5	agreement	agreement	NN
cord-006229-7yoilsho	5644	6	with	with	IN
cord-006229-7yoilsho	5644	7	the	the	DT
cord-006229-7yoilsho	5644	8	enhanced	enhanced	JJ
cord-006229-7yoilsho	5644	9	formation	formation	NN
cord-006229-7yoilsho	5644	10	of	of	IN
cord-006229-7yoilsho	5644	11	autophagosomes	autophagosomes	NNP
cord-006229-7yoilsho	5644	12	and	and	CC
cord-006229-7yoilsho	5644	13	the	the	DT
cord-006229-7yoilsho	5644	14	dose	dose	NN
cord-006229-7yoilsho	5644	15	-	-	HYPH
cord-006229-7yoilsho	5644	16	dependent	dependent	JJ
cord-006229-7yoilsho	5644	17	decrease	decrease	NN
cord-006229-7yoilsho	5644	18	of	of	IN
cord-006229-7yoilsho	5644	19	the	the	DT
cord-006229-7yoilsho	5644	20	autophagy	autophagy	NN
cord-006229-7yoilsho	5644	21	substrate	substrate	NN
cord-006229-7yoilsho	5644	22	p62	p62	NN
cord-006229-7yoilsho	5644	23	as	as	RB
cord-006229-7yoilsho	5644	24	observed	observe	VBN
cord-006229-7yoilsho	5644	25	by	by	IN
cord-006229-7yoilsho	5644	26	flow	flow	NN
cord-006229-7yoilsho	5644	27	cytometry	cytometry	NN
cord-006229-7yoilsho	5644	28	and	and	CC
cord-006229-7yoilsho	5644	29	Western	western	JJ
cord-006229-7yoilsho	5644	30	blot	blot	NN
cord-006229-7yoilsho	5644	31	analysis	analysis	NN
cord-006229-7yoilsho	5644	32	in	in	IN
cord-006229-7yoilsho	5644	33	HCT116	HCT116	NNP
cord-006229-7yoilsho	5644	34	,	,	,
cord-006229-7yoilsho	5644	35	SW48	SW48	NNP
cord-006229-7yoilsho	5644	36	and	and	CC
cord-006229-7yoilsho	5644	37	HCEC	HCEC	NNP
cord-006229-7yoilsho	5644	38	.	.	.
cord-006229-7yoilsho	5645	1	CDT	CDT	NNP
cord-006229-7yoilsho	5645	2	-	-	HYPH
cord-006229-7yoilsho	5645	3	and	and	CC
cord-006229-7yoilsho	5645	4	IRinduced	irinduced	JJ
cord-006229-7yoilsho	5645	5	autophagy	autophagy	NN
cord-006229-7yoilsho	5645	6	rates	rate	NNS
cord-006229-7yoilsho	5645	7	in	in	IN
cord-006229-7yoilsho	5645	8	HCT116	HCT116	NNP
cord-006229-7yoilsho	5645	9	increased	increase	VBD
cord-006229-7yoilsho	5645	10	over	over	IN
cord-006229-7yoilsho	5645	11	time	time	NN
cord-006229-7yoilsho	5645	12	correlating	correlate	VBG
cord-006229-7yoilsho	5645	13	well	well	RB
cord-006229-7yoilsho	5645	14	with	with	IN
cord-006229-7yoilsho	5645	15	the	the	DT
cord-006229-7yoilsho	5645	16	DSB	DSB	NNP
cord-006229-7yoilsho	5645	17	induction	induction	NN
cord-006229-7yoilsho	5645	18	.	.	.
cord-006229-7yoilsho	5646	1	Importantly	importantly	RB
cord-006229-7yoilsho	5646	2	,	,	,
cord-006229-7yoilsho	5646	3	a	a	DT
cord-006229-7yoilsho	5646	4	DNaseI	dnasei	JJ
cord-006229-7yoilsho	5646	5	-	-	HYPH
cord-006229-7yoilsho	5646	6	defective	defective	JJ
cord-006229-7yoilsho	5646	7	mutant	mutant	NN
cord-006229-7yoilsho	5646	8	of	of	IN
cord-006229-7yoilsho	5646	9	CDT	CDT	NNP
cord-006229-7yoilsho	5646	10	did	do	VBD
cord-006229-7yoilsho	5646	11	neither	neither	CC
cord-006229-7yoilsho	5646	12	cause	cause	VB
cord-006229-7yoilsho	5646	13	DSBs	dsb	NNS
cord-006229-7yoilsho	5646	14	nor	nor	CC
cord-006229-7yoilsho	5646	15	induce	induce	VB
cord-006229-7yoilsho	5646	16	autophagy	autophagy	NN
cord-006229-7yoilsho	5646	17	.	.	.
cord-006229-7yoilsho	5647	1	Additionally	additionally	RB
cord-006229-7yoilsho	5647	2	,	,	,
cord-006229-7yoilsho	5647	3	the	the	DT
cord-006229-7yoilsho	5647	4	time	time	NN
cord-006229-7yoilsho	5647	5	-	-	HYPH
cord-006229-7yoilsho	5647	6	dependent	dependent	JJ
cord-006229-7yoilsho	5647	7	accumulation	accumulation	NN
cord-006229-7yoilsho	5647	8	of	of	IN
cord-006229-7yoilsho	5647	9	the	the	DT
cord-006229-7yoilsho	5647	10	lysosomal	lysosomal	NN
cord-006229-7yoilsho	5647	11	associated	associate	VBD
cord-006229-7yoilsho	5647	12	membrane	membrane	NN
cord-006229-7yoilsho	5647	13	protein	protein	NN
cord-006229-7yoilsho	5647	14	1	1	CD
cord-006229-7yoilsho	5647	15	(	(	-LRB-
cord-006229-7yoilsho	5647	16	LAMP-1	LAMP-1	NNP
cord-006229-7yoilsho	5647	17	)	)	-RRB-
cord-006229-7yoilsho	5647	18	was	be	VBD
cord-006229-7yoilsho	5647	19	observed	observe	VBN
cord-006229-7yoilsho	5647	20	by	by	IN
cord-006229-7yoilsho	5647	21	confocal	confocal	JJ
cord-006229-7yoilsho	5647	22	immunofluorescence	immunofluorescence	NN
cord-006229-7yoilsho	5647	23	microscopy	microscopy	NN
cord-006229-7yoilsho	5647	24	.	.	.
cord-006229-7yoilsho	5648	1	DSB	DSB	NNP
cord-006229-7yoilsho	5648	2	-	-	HYPH
cord-006229-7yoilsho	5648	3	induced	induce	VBN
cord-006229-7yoilsho	5648	4	autophagy	autophagy	NN
cord-006229-7yoilsho	5648	5	was	be	VBD
cord-006229-7yoilsho	5648	6	blocked	block	VBN
cord-006229-7yoilsho	5648	7	by	by	IN
cord-006229-7yoilsho	5648	8	chemical	chemical	NN
cord-006229-7yoilsho	5648	9	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	5648	10	.	.	.
cord-006229-7yoilsho	5649	1	Next	next	RB
cord-006229-7yoilsho	5649	2	,	,	,
cord-006229-7yoilsho	5649	3	we	-PRON-	PRP
cord-006229-7yoilsho	5649	4	showed	show	VBD
cord-006229-7yoilsho	5649	5	that	that	IN
cord-006229-7yoilsho	5649	6	both	both	DT
cord-006229-7yoilsho	5649	7	IR	IR	NNP
cord-006229-7yoilsho	5649	8	and	and	CC
cord-006229-7yoilsho	5649	9	,	,	,
cord-006229-7yoilsho	5649	10	to	to	IN
cord-006229-7yoilsho	5649	11	a	a	DT
cord-006229-7yoilsho	5649	12	lesser	less	JJR
cord-006229-7yoilsho	5649	13	degree	degree	NN
cord-006229-7yoilsho	5649	14	,	,	,
cord-006229-7yoilsho	5649	15	CDT	CDT	NNP
cord-006229-7yoilsho	5649	16	induce	induce	VBP
cord-006229-7yoilsho	5649	17	the	the	DT
cord-006229-7yoilsho	5649	18	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	5649	19	of	of	IN
cord-006229-7yoilsho	5649	20	Akt	Akt	NNP
cord-006229-7yoilsho	5649	21	at	at	IN
cord-006229-7yoilsho	5649	22	Ser473	ser473	CD
cord-006229-7yoilsho	5649	23	.	.	.
cord-006229-7yoilsho	5650	1	Pharmacological	pharmacological	JJ
cord-006229-7yoilsho	5650	2	inhibition	inhibition	NN
cord-006229-7yoilsho	5650	3	of	of	IN
cord-006229-7yoilsho	5650	4	Akt	Akt	NNP
cord-006229-7yoilsho	5650	5	in	in	IN
cord-006229-7yoilsho	5650	6	HCT116	hct116	JJ
cord-006229-7yoilsho	5650	7	cells	cell	NNS
cord-006229-7yoilsho	5650	8	enhanced	enhance	VBD
cord-006229-7yoilsho	5650	9	the	the	DT
cord-006229-7yoilsho	5650	10	CDT	CDT	NNP
cord-006229-7yoilsho	5650	11	-	-	HYPH
cord-006229-7yoilsho	5650	12	and	and	CC
cord-006229-7yoilsho	5650	13	IR	IR	NNP
cord-006229-7yoilsho	5650	14	-	-	HYPH
cord-006229-7yoilsho	5650	15	induced	induce	VBN
cord-006229-7yoilsho	5650	16	autophagy	autophagy	NN
cord-006229-7yoilsho	5650	17	shown	show	VBN
cord-006229-7yoilsho	5650	18	by	by	IN
cord-006229-7yoilsho	5650	19	accumulation	accumulation	NN
cord-006229-7yoilsho	5650	20	of	of	IN
cord-006229-7yoilsho	5650	21	LC3B	lc3b	NN
cord-006229-7yoilsho	5650	22	and	and	CC
cord-006229-7yoilsho	5650	23	LAMP1	LAMP1	NNP
cord-006229-7yoilsho	5650	24	after	after	IN
cord-006229-7yoilsho	5650	25	48	48	CD
cord-006229-7yoilsho	5650	26	h	h	NN
cord-006229-7yoilsho	5650	27	and	and	CC
cord-006229-7yoilsho	5650	28	increased	increase	VBN
cord-006229-7yoilsho	5650	29	autophagosome	autophagosome	JJ
cord-006229-7yoilsho	5650	30	formation	formation	NN
cord-006229-7yoilsho	5650	31	.	.	.
cord-006229-7yoilsho	5651	1	Upregulation	upregulation	NN
cord-006229-7yoilsho	5651	2	of	of	IN
cord-006229-7yoilsho	5651	3	DSBinduced	dsbinduced	JJ
cord-006229-7yoilsho	5651	4	autophagy	autophagy	NN
cord-006229-7yoilsho	5651	5	by	by	IN
cord-006229-7yoilsho	5651	6	Akt	Akt	NNP
cord-006229-7yoilsho	5651	7	inhibition	inhibition	NN
cord-006229-7yoilsho	5651	8	resulted	result	VBD
cord-006229-7yoilsho	5651	9	in	in	IN
cord-006229-7yoilsho	5651	10	a	a	DT
cord-006229-7yoilsho	5651	11	decreased	decrease	VBN
cord-006229-7yoilsho	5651	12	cytotoxicity	cytotoxicity	NN
cord-006229-7yoilsho	5651	13	after	after	IN
cord-006229-7yoilsho	5651	14	72	72	CD
cord-006229-7yoilsho	5651	15	h	h	NN
cord-006229-7yoilsho	5651	16	and	and	CC
cord-006229-7yoilsho	5651	17	significantly	significantly	RB
cord-006229-7yoilsho	5651	18	lower	low	JJR
cord-006229-7yoilsho	5651	19	apoptosis	apoptosis	NN
cord-006229-7yoilsho	5651	20	/	/	SYM
cord-006229-7yoilsho	5651	21	necrosis	necrosis	NN
cord-006229-7yoilsho	5651	22	rates	rate	NNS
cord-006229-7yoilsho	5651	23	after	after	IN
cord-006229-7yoilsho	5651	24	48	48	CD
cord-006229-7yoilsho	5651	25	h	h	NN
cord-006229-7yoilsho	5651	26	,	,	,
cord-006229-7yoilsho	5651	27	which	which	WDT
cord-006229-7yoilsho	5651	28	were	be	VBD
cord-006229-7yoilsho	5651	29	determined	determine	VBN
cord-006229-7yoilsho	5651	30	by	by	IN
cord-006229-7yoilsho	5651	31	MTS	MTS	NNP
cord-006229-7yoilsho	5651	32	cell	cell	NN
cord-006229-7yoilsho	5651	33	viability	viability	NN
cord-006229-7yoilsho	5651	34	assay	assay	NN
cord-006229-7yoilsho	5651	35	and	and	CC
cord-006229-7yoilsho	5651	36	Annexin	Annexin	NNP
cord-006229-7yoilsho	5651	37	-	-	HYPH
cord-006229-7yoilsho	5651	38	V	V	NNP
cord-006229-7yoilsho	5651	39	/	/	SYM
cord-006229-7yoilsho	5651	40	PI	pi	NN
cord-006229-7yoilsho	5651	41	staining	staining	NN
cord-006229-7yoilsho	5651	42	.	.	.
cord-006229-7yoilsho	5652	1	Ongoing	ongoing	JJ
cord-006229-7yoilsho	5652	2	studies	study	NNS
cord-006229-7yoilsho	5652	3	will	will	MD
cord-006229-7yoilsho	5652	4	evaluate	evaluate	VB
cord-006229-7yoilsho	5652	5	the	the	DT
cord-006229-7yoilsho	5652	6	impact	impact	NN
cord-006229-7yoilsho	5652	7	of	of	IN
cord-006229-7yoilsho	5652	8	other	other	JJ
cord-006229-7yoilsho	5652	9	DNA	dna	NN
cord-006229-7yoilsho	5652	10	damage	damage	NN
cord-006229-7yoilsho	5652	11	response	response	NN
cord-006229-7yoilsho	5652	12	pathways	pathway	NNS
cord-006229-7yoilsho	5652	13	and	and	CC
cord-006229-7yoilsho	5652	14	the	the	DT
cord-006229-7yoilsho	5652	15	potential	potential	JJ
cord-006229-7yoilsho	5652	16	protective	protective	JJ
cord-006229-7yoilsho	5652	17	role	role	NN
cord-006229-7yoilsho	5652	18	of	of	IN
cord-006229-7yoilsho	5652	19	autophagy	autophagy	NN
cord-006229-7yoilsho	5652	20	against	against	IN
cord-006229-7yoilsho	5652	21	genomic	genomic	JJ
cord-006229-7yoilsho	5652	22	instability	instability	NN
cord-006229-7yoilsho	5652	23	.	.	.
cord-006229-7yoilsho	5653	1	Mustard	mustard	NN
cord-006229-7yoilsho	5653	2	agents	agent	NNS
cord-006229-7yoilsho	5653	3	are	be	VBP
cord-006229-7yoilsho	5653	4	potent	potent	JJ
cord-006229-7yoilsho	5653	5	DNA	dna	NN
cord-006229-7yoilsho	5653	6	alkylating	alkylate	VBG
cord-006229-7yoilsho	5653	7	agents	agent	NNS
cord-006229-7yoilsho	5653	8	.	.	.
cord-006229-7yoilsho	5654	1	Among	among	IN
cord-006229-7yoilsho	5654	2	them	-PRON-	PRP
cord-006229-7yoilsho	5654	3	,	,	,
cord-006229-7yoilsho	5654	4	the	the	DT
cord-006229-7yoilsho	5654	5	bi	bi	JJ
cord-006229-7yoilsho	5654	6	-	-	JJ
cord-006229-7yoilsho	5654	7	functional	functional	JJ
cord-006229-7yoilsho	5654	8	agent	agent	NN
cord-006229-7yoilsho	5654	9	sulfur	sulfur	NN
cord-006229-7yoilsho	5654	10	mustard	mustard	NN
cord-006229-7yoilsho	5654	11	(	(	-LRB-
cord-006229-7yoilsho	5654	12	SM	SM	NNP
cord-006229-7yoilsho	5654	13	)	)	-RRB-
cord-006229-7yoilsho	5654	14	was	be	VBD
cord-006229-7yoilsho	5654	15	used	use	VBN
cord-006229-7yoilsho	5654	16	as	as	IN
cord-006229-7yoilsho	5654	17	a	a	DT
cord-006229-7yoilsho	5654	18	chemical	chemical	JJ
cord-006229-7yoilsho	5654	19	warfare	warfare	NN
cord-006229-7yoilsho	5654	20	agent	agent	NN
cord-006229-7yoilsho	5654	21	due	due	IN
cord-006229-7yoilsho	5654	22	to	to	IN
cord-006229-7yoilsho	5654	23	its	-PRON-	PRP$
cord-006229-7yoilsho	5654	24	vesicant	vesicant	NN
cord-006229-7yoilsho	5654	25	properties	property	NNS
cord-006229-7yoilsho	5654	26	.	.	.
cord-006229-7yoilsho	5655	1	Although	although	IN
cord-006229-7yoilsho	5655	2	the	the	DT
cord-006229-7yoilsho	5655	3	use	use	NN
cord-006229-7yoilsho	5655	4	of	of	IN
cord-006229-7yoilsho	5655	5	SM	SM	NNP
cord-006229-7yoilsho	5655	6	in	in	IN
cord-006229-7yoilsho	5655	7	warfare	warfare	NN
cord-006229-7yoilsho	5655	8	has	have	VBZ
cord-006229-7yoilsho	5655	9	been	be	VBN
cord-006229-7yoilsho	5655	10	banned	ban	VBN
cord-006229-7yoilsho	5655	11	in	in	IN
cord-006229-7yoilsho	5655	12	most	most	JJS
cord-006229-7yoilsho	5655	13	countries	country	NNS
cord-006229-7yoilsho	5655	14	of	of	IN
cord-006229-7yoilsho	5655	15	the	the	DT
cord-006229-7yoilsho	5655	16	world	world	NN
cord-006229-7yoilsho	5655	17	,	,	,
cord-006229-7yoilsho	5655	18	its	-PRON-	PRP$
cord-006229-7yoilsho	5655	19	use	use	NN
cord-006229-7yoilsho	5655	20	in	in	IN
cord-006229-7yoilsho	5655	21	terroristic	terroristic	JJ
cord-006229-7yoilsho	5655	22	attacks	attack	NNS
cord-006229-7yoilsho	5655	23	or	or	CC
cord-006229-7yoilsho	5655	24	asymmetrical	asymmetrical	JJ
cord-006229-7yoilsho	5655	25	conflicts	conflict	NNS
cord-006229-7yoilsho	5655	26	,	,	,
cord-006229-7yoilsho	5655	27	such	such	JJ
cord-006229-7yoilsho	5655	28	as	as	IN
cord-006229-7yoilsho	5655	29	the	the	DT
cord-006229-7yoilsho	5655	30	Syrian	syrian	JJ
cord-006229-7yoilsho	5655	31	civil	civil	JJ
cord-006229-7yoilsho	5655	32	war	war	NN
cord-006229-7yoilsho	5655	33	,	,	,
cord-006229-7yoilsho	5655	34	still	still	RB
cord-006229-7yoilsho	5655	35	represents	represent	VBZ
cord-006229-7yoilsho	5655	36	a	a	DT
cord-006229-7yoilsho	5655	37	realistic	realistic	JJ
cord-006229-7yoilsho	5655	38	and	and	CC
cord-006229-7yoilsho	5655	39	significant	significant	JJ
cord-006229-7yoilsho	5655	40	threat	threat	NN
cord-006229-7yoilsho	5655	41	.	.	.
cord-006229-7yoilsho	5656	1	On	on	IN
cord-006229-7yoilsho	5656	2	the	the	DT
cord-006229-7yoilsho	5656	3	other	other	JJ
cord-006229-7yoilsho	5656	4	hand	hand	NN
cord-006229-7yoilsho	5656	5	,	,	,
cord-006229-7yoilsho	5656	6	especially	especially	RB
cord-006229-7yoilsho	5656	7	nitrogen	nitrogen	NN
cord-006229-7yoilsho	5656	8	mustards	mustard	NNS
cord-006229-7yoilsho	5656	9	,	,	,
cord-006229-7yoilsho	5656	10	such	such	JJ
cord-006229-7yoilsho	5656	11	as	as	IN
cord-006229-7yoilsho	5656	12	cyclophosphamide	cyclophosphamide	NN
cord-006229-7yoilsho	5656	13	or	or	CC
cord-006229-7yoilsho	5656	14	melphalan	melphalan	NNP
cord-006229-7yoilsho	5656	15	,	,	,
cord-006229-7yoilsho	5656	16	have	have	VBP
cord-006229-7yoilsho	5656	17	been	be	VBN
cord-006229-7yoilsho	5656	18	used	use	VBN
cord-006229-7yoilsho	5656	19	as	as	IN
cord-006229-7yoilsho	5656	20	chemotherapeutic	chemotherapeutic	JJ
cord-006229-7yoilsho	5656	21	agents	agent	NNS
cord-006229-7yoilsho	5656	22	due	due	JJ
cord-006229-7yoilsho	5656	23	to	to	IN
cord-006229-7yoilsho	5656	24	their	-PRON-	PRP$
cord-006229-7yoilsho	5656	25	cytostatic	cytostatic	JJ
cord-006229-7yoilsho	5656	26	properties	property	NNS
cord-006229-7yoilsho	5656	27	.	.	.
cord-006229-7yoilsho	5657	1	Thus	thus	RB
cord-006229-7yoilsho	5657	2	,	,	,
cord-006229-7yoilsho	5657	3	mustard	mustard	NN
cord-006229-7yoilsho	5657	4	-	-	HYPH
cord-006229-7yoilsho	5657	5	induced	induce	VBN
cord-006229-7yoilsho	5657	6	DNA	dna	NN
cord-006229-7yoilsho	5657	7	damage	damage	NN
cord-006229-7yoilsho	5657	8	,	,	,
cord-006229-7yoilsho	5657	9	in	in	IN
cord-006229-7yoilsho	5657	10	particular	particular	JJ
cord-006229-7yoilsho	5657	11	DNA	dna	NN
cord-006229-7yoilsho	5657	12	crosslinks	crosslink	NNS
cord-006229-7yoilsho	5657	13	,	,	,
cord-006229-7yoilsho	5657	14	can	can	MD
cord-006229-7yoilsho	5657	15	trigger	trigger	VB
cord-006229-7yoilsho	5657	16	complex	complex	JJ
cord-006229-7yoilsho	5657	17	pathological	pathological	JJ
cord-006229-7yoilsho	5657	18	states	state	NNS
cord-006229-7yoilsho	5657	19	,	,	,
cord-006229-7yoilsho	5657	20	as	as	IN
cord-006229-7yoilsho	5657	21	it	-PRON-	PRP
cord-006229-7yoilsho	5657	22	is	be	VBZ
cord-006229-7yoilsho	5657	23	observed	observe	VBN
cord-006229-7yoilsho	5657	24	in	in	IN
cord-006229-7yoilsho	5657	25	sulfur	sulfur	NN
cord-006229-7yoilsho	5657	26	mustard	mustard	NN
cord-006229-7yoilsho	5657	27	exposed	expose	VBN
cord-006229-7yoilsho	5657	28	victims	victim	NNS
cord-006229-7yoilsho	5657	29	,	,	,
cord-006229-7yoilsho	5657	30	but	but	CC
cord-006229-7yoilsho	5657	31	on	on	IN
cord-006229-7yoilsho	5657	32	the	the	DT
cord-006229-7yoilsho	5657	33	other	other	JJ
cord-006229-7yoilsho	5657	34	hand	hand	NN
cord-006229-7yoilsho	5657	35	also	also	RB
cord-006229-7yoilsho	5657	36	lead	lead	VBP
cord-006229-7yoilsho	5657	37	to	to	IN
cord-006229-7yoilsho	5657	38	the	the	DT
cord-006229-7yoilsho	5657	39	chemotherapeutic	chemotherapeutic	JJ
cord-006229-7yoilsho	5657	40	effects	effect	NNS
cord-006229-7yoilsho	5657	41	of	of	IN
cord-006229-7yoilsho	5657	42	clinically	clinically	RB
cord-006229-7yoilsho	5657	43	-	-	HYPH
cord-006229-7yoilsho	5657	44	used	use	VBN
cord-006229-7yoilsho	5657	45	nitrogen	nitrogen	NN
cord-006229-7yoilsho	5657	46	mustards	mustard	NNS
cord-006229-7yoilsho	5657	47	.	.	.
cord-006229-7yoilsho	5658	1	Mass	mass	JJ
cord-006229-7yoilsho	5658	2	spectrometric	spectrometric	JJ
cord-006229-7yoilsho	5658	3	monitoring	monitoring	NN
cord-006229-7yoilsho	5658	4	and	and	CC
cord-006229-7yoilsho	5658	5	quantitation	quantitation	NN
cord-006229-7yoilsho	5658	6	of	of	IN
cord-006229-7yoilsho	5658	7	mustard	mustard	NN
cord-006229-7yoilsho	5658	8	-	-	HYPH
cord-006229-7yoilsho	5658	9	induced	induce	VBN
cord-006229-7yoilsho	5658	10	DNA	dna	NN
cord-006229-7yoilsho	5658	11	adducts	adduct	NNS
cord-006229-7yoilsho	5658	12	can	can	MD
cord-006229-7yoilsho	5658	13	help	help	VB
cord-006229-7yoilsho	5658	14	to	to	TO
cord-006229-7yoilsho	5658	15	unambiguously	unambiguously	RB
cord-006229-7yoilsho	5658	16	identify	identify	VB
cord-006229-7yoilsho	5658	17	and	and	CC
cord-006229-7yoilsho	5658	18	verify	verify	VB
cord-006229-7yoilsho	5658	19	SM	sm	NN
cord-006229-7yoilsho	5658	20	-	-	HYPH
cord-006229-7yoilsho	5658	21	exposed	expose	VBN
cord-006229-7yoilsho	5658	22	victims	victim	NNS
cord-006229-7yoilsho	5658	23	and	and	CC
cord-006229-7yoilsho	5658	24	to	to	TO
cord-006229-7yoilsho	5658	25	monitor	monitor	VB
cord-006229-7yoilsho	5658	26	the	the	DT
cord-006229-7yoilsho	5658	27	efficiency	efficiency	NN
cord-006229-7yoilsho	5658	28	,	,	,
cord-006229-7yoilsho	5658	29	as	as	RB
cord-006229-7yoilsho	5658	30	well	well	RB
cord-006229-7yoilsho	5658	31	as	as	IN
cord-006229-7yoilsho	5658	32	potential	potential	JJ
cord-006229-7yoilsho	5658	33	side	side	NN
cord-006229-7yoilsho	5658	34	-	-	HYPH
cord-006229-7yoilsho	5658	35	effects	effect	NNS
cord-006229-7yoilsho	5658	36	of	of	IN
cord-006229-7yoilsho	5658	37	mustard	mustard	NN
cord-006229-7yoilsho	5658	38	-	-	HYPH
cord-006229-7yoilsho	5658	39	based	base	VBN
cord-006229-7yoilsho	5658	40	chemotherapy	chemotherapy	NN
cord-006229-7yoilsho	5658	41	.	.	.
cord-006229-7yoilsho	5659	1	Up	up	IN
cord-006229-7yoilsho	5659	2	to	to	IN
cord-006229-7yoilsho	5659	3	now	now	RB
cord-006229-7yoilsho	5659	4	,	,	,
cord-006229-7yoilsho	5659	5	the	the	DT
cord-006229-7yoilsho	5659	6	verification	verification	NN
cord-006229-7yoilsho	5659	7	of	of	IN
cord-006229-7yoilsho	5659	8	mustard	mustard	NN
cord-006229-7yoilsho	5659	9	-	-	HYPH
cord-006229-7yoilsho	5659	10	induced	induce	VBN
cord-006229-7yoilsho	5659	11	nucleic	nucleic	JJ
cord-006229-7yoilsho	5659	12	acid	acid	NN
cord-006229-7yoilsho	5659	13	damage	damage	NN
cord-006229-7yoilsho	5659	14	is	be	VBZ
cord-006229-7yoilsho	5659	15	mainly	mainly	RB
cord-006229-7yoilsho	5659	16	based	base	VBN
cord-006229-7yoilsho	5659	17	on	on	IN
cord-006229-7yoilsho	5659	18	immunohistochemical	immunohistochemical	JJ
cord-006229-7yoilsho	5659	19	methods	method	NNS
cord-006229-7yoilsho	5659	20	,	,	,
cord-006229-7yoilsho	5659	21	which	which	WDT
cord-006229-7yoilsho	5659	22	have	have	VBP
cord-006229-7yoilsho	5659	23	several	several	JJ
cord-006229-7yoilsho	5659	24	drawbacks	drawback	NNS
cord-006229-7yoilsho	5659	25	such	such	JJ
cord-006229-7yoilsho	5659	26	as	as	IN
cord-006229-7yoilsho	5659	27	limited	limited	JJ
cord-006229-7yoilsho	5659	28	specificity	specificity	NN
cord-006229-7yoilsho	5659	29	,	,	,
cord-006229-7yoilsho	5659	30	sensitivity	sensitivity	NN
cord-006229-7yoilsho	5659	31	,	,	,
cord-006229-7yoilsho	5659	32	and	and	CC
cord-006229-7yoilsho	5659	33	low	low	JJ
cord-006229-7yoilsho	5659	34	dynamic	dynamic	JJ
cord-006229-7yoilsho	5659	35	range	range	NN
cord-006229-7yoilsho	5659	36	of	of	IN
cord-006229-7yoilsho	5659	37	quantitation	quantitation	NN
cord-006229-7yoilsho	5659	38	.	.	.
cord-006229-7yoilsho	5660	1	With	with	IN
cord-006229-7yoilsho	5660	2	this	this	DT
cord-006229-7yoilsho	5660	3	project	project	NN
cord-006229-7yoilsho	5660	4	,	,	,
cord-006229-7yoilsho	5660	5	we	-PRON-	PRP
cord-006229-7yoilsho	5660	6	aim	aim	VBP
cord-006229-7yoilsho	5660	7	to	to	TO
cord-006229-7yoilsho	5660	8	develop	develop	VB
cord-006229-7yoilsho	5660	9	a	a	DT
cord-006229-7yoilsho	5660	10	(	(	-LRB-
cord-006229-7yoilsho	5660	11	HPLC	HPLC	NNP
cord-006229-7yoilsho	5660	12	/	/	SYM
cord-006229-7yoilsho	5660	13	UPLC)-MS	UPLC)-MS	NNP
cord-006229-7yoilsho	5660	14	/	/	SYM
cord-006229-7yoilsho	5660	15	MS	MS	NNP
cord-006229-7yoilsho	5660	16	-	-	HYPH
cord-006229-7yoilsho	5660	17	based	base	VBN
cord-006229-7yoilsho	5660	18	platform	platform	NN
cord-006229-7yoilsho	5660	19	for	for	IN
cord-006229-7yoilsho	5660	20	the	the	DT
cord-006229-7yoilsho	5660	21	quantitation	quantitation	NN
cord-006229-7yoilsho	5660	22	of	of	IN
cord-006229-7yoilsho	5660	23	the	the	DT
cord-006229-7yoilsho	5660	24	most	most	RBS
cord-006229-7yoilsho	5660	25	common	common	JJ
cord-006229-7yoilsho	5660	26	mustard	mustard	NN
cord-006229-7yoilsho	5660	27	-	-	HYPH
cord-006229-7yoilsho	5660	28	induced	induce	VBN
cord-006229-7yoilsho	5660	29	DNA	dna	NN
cord-006229-7yoilsho	5660	30	adducts	adduct	NNS
cord-006229-7yoilsho	5660	31	including	include	VBG
cord-006229-7yoilsho	5660	32	bis(N7-guanine	bis(n7-guanine	JJ
cord-006229-7yoilsho	5660	33	-	-	HYPH
cord-006229-7yoilsho	5660	34	ethyl	ethyl	NN
cord-006229-7yoilsho	5660	35	)	)	-RRB-
cord-006229-7yoilsho	5660	36	sulfide	sulfide	NN
cord-006229-7yoilsho	5660	37	DNA	dna	NN
cord-006229-7yoilsho	5660	38	crosslinks	crosslink	NNS
cord-006229-7yoilsho	5660	39	.	.	.
cord-006229-7yoilsho	5661	1	Up	up	IN
cord-006229-7yoilsho	5661	2	to	to	IN
cord-006229-7yoilsho	5661	3	date	date	NN
cord-006229-7yoilsho	5661	4	,	,	,
cord-006229-7yoilsho	5661	5	we	-PRON-	PRP
cord-006229-7yoilsho	5661	6	established	establish	VBD
cord-006229-7yoilsho	5661	7	methods	method	NNS
cord-006229-7yoilsho	5661	8	for	for	IN
cord-006229-7yoilsho	5661	9	the	the	DT
cord-006229-7yoilsho	5661	10	quantitation	quantitation	NN
cord-006229-7yoilsho	5661	11	of	of	IN
cord-006229-7yoilsho	5661	12	the	the	DT
cord-006229-7yoilsho	5661	13	several	several	JJ
cord-006229-7yoilsho	5661	14	common	common	JJ
cord-006229-7yoilsho	5661	15	DNA	dna	NN
cord-006229-7yoilsho	5661	16	adducts	adduct	NNS
cord-006229-7yoilsho	5661	17	induced	induce	VBN
cord-006229-7yoilsho	5661	18	by	by	IN
cord-006229-7yoilsho	5661	19	the	the	DT
cord-006229-7yoilsho	5661	20	mono	mono	JJ
cord-006229-7yoilsho	5661	21	-	-	JJ
cord-006229-7yoilsho	5661	22	functional	functional	JJ
cord-006229-7yoilsho	5661	23	sulfur	sulfur	NN
cord-006229-7yoilsho	5661	24	-	-	HYPH
cord-006229-7yoilsho	5661	25	mustard	mustard	NN
cord-006229-7yoilsho	5661	26	derivative	derivative	JJ
cord-006229-7yoilsho	5661	27	2chloroethyl	2chloroethyl	CD
cord-006229-7yoilsho	5661	28	ethyl	ethyl	NN
cord-006229-7yoilsho	5661	29	sulfide	sulfide	NN
cord-006229-7yoilsho	5661	30	(	(	-LRB-
cord-006229-7yoilsho	5661	31	"	"	``
cord-006229-7yoilsho	5661	32	half	half	JJ
cord-006229-7yoilsho	5661	33	mustard	mustard	NN
cord-006229-7yoilsho	5661	34	"	"	''
cord-006229-7yoilsho	5661	35	,	,	,
cord-006229-7yoilsho	5661	36	CEES	CEES	NNP
cord-006229-7yoilsho	5661	37	)	)	-RRB-
cord-006229-7yoilsho	5661	38	.	.	.
cord-006229-7yoilsho	5662	1	For	for	IN
cord-006229-7yoilsho	5662	2	that	that	DT
cord-006229-7yoilsho	5662	3	reason	reason	NN
cord-006229-7yoilsho	5662	4	purification	purification	NN
cord-006229-7yoilsho	5662	5	protocols	protocol	NNS
cord-006229-7yoilsho	5662	6	,	,	,
cord-006229-7yoilsho	5662	7	chromatographic	chromatographic	JJ
cord-006229-7yoilsho	5662	8	conditions	condition	NNS
cord-006229-7yoilsho	5662	9	and	and	CC
cord-006229-7yoilsho	5662	10	mass	mass	JJ
cord-006229-7yoilsho	5662	11	spectrometric	spectrometric	NN
cord-006229-7yoilsho	5662	12	settings	setting	NNS
cord-006229-7yoilsho	5662	13	were	be	VBD
cord-006229-7yoilsho	5662	14	developed	develop	VBN
cord-006229-7yoilsho	5662	15	to	to	TO
cord-006229-7yoilsho	5662	16	detect	detect	VB
cord-006229-7yoilsho	5662	17	N7-ethylthioethyl-2´desoxyguanosine	N7-ethylthioethyl-2´desoxyguanosine	NNP
cord-006229-7yoilsho	5662	18	(	(	-LRB-
cord-006229-7yoilsho	5662	19	N7-ETE	N7-ETE	NNP
cord-006229-7yoilsho	5662	20	-	-	HYPH
cord-006229-7yoilsho	5662	21	dG	dG	NNP
cord-006229-7yoilsho	5662	22	)	)	-RRB-
cord-006229-7yoilsho	5662	23	and	and	CC
cord-006229-7yoilsho	5662	24	N3-ethylthioethyl-2´desoxyadenosine	N3-ethylthioethyl-2´desoxyadenosine	NNP
cord-006229-7yoilsho	5662	25	(	(	-LRB-
cord-006229-7yoilsho	5662	26	N3-ETE	N3-ETE	NNP
cord-006229-7yoilsho	5662	27	-	-	HYPH
cord-006229-7yoilsho	5662	28	dA	dA	NNP
cord-006229-7yoilsho	5662	29	)	)	-RRB-
cord-006229-7yoilsho	5662	30	and	and	CC
cord-006229-7yoilsho	5662	31	their	-PRON-	PRP$
cord-006229-7yoilsho	5662	32	thermal	thermal	JJ
cord-006229-7yoilsho	5662	33	hydrolysis	hydrolysis	NN
cord-006229-7yoilsho	5662	34	products	product	NNS
cord-006229-7yoilsho	5662	35	N7ethylthioethyl	n7ethylthioethyl	NN
cord-006229-7yoilsho	5662	36	-	-	HYPH
cord-006229-7yoilsho	5662	37	guanine	guanine	NN
cord-006229-7yoilsho	5662	38	(	(	-LRB-
cord-006229-7yoilsho	5662	39	N7-ETE	N7-ETE	NNP
cord-006229-7yoilsho	5662	40	-	-	HYPH
cord-006229-7yoilsho	5662	41	Gua	Gua	NNP
cord-006229-7yoilsho	5662	42	)	)	-RRB-
cord-006229-7yoilsho	5662	43	and	and	CC
cord-006229-7yoilsho	5662	44	N3-ethylthioethyl	n3-ethylthioethyl	NN
cord-006229-7yoilsho	5662	45	-	-	HYPH
cord-006229-7yoilsho	5662	46	adenine	adenine	NN
cord-006229-7yoilsho	5662	47	(	(	-LRB-
cord-006229-7yoilsho	5662	48	N3-ETE	N3-ETE	NNP
cord-006229-7yoilsho	5662	49	-	-	HYPH
cord-006229-7yoilsho	5662	50	Ade	Ade	NNP
cord-006229-7yoilsho	5662	51	)	)	-RRB-
cord-006229-7yoilsho	5662	52	,	,	,
cord-006229-7yoilsho	5662	53	respectively	respectively	RB
cord-006229-7yoilsho	5662	54	,	,	,
cord-006229-7yoilsho	5662	55	and	and	CC
cord-006229-7yoilsho	5662	56	the	the	DT
cord-006229-7yoilsho	5662	57	sensitivity	sensitivity	NN
cord-006229-7yoilsho	5662	58	was	be	VBD
cord-006229-7yoilsho	5662	59	compared	compare	VBN
cord-006229-7yoilsho	5662	60	to	to	IN
cord-006229-7yoilsho	5662	61	immunohistochemical	immunohistochemical	JJ
cord-006229-7yoilsho	5662	62	methods	method	NNS
cord-006229-7yoilsho	5662	63	.	.	.
cord-006229-7yoilsho	5663	1	Additional	additional	JJ
cord-006229-7yoilsho	5663	2	non	non	JJ
cord-006229-7yoilsho	5663	3	-	-	JJ
cord-006229-7yoilsho	5663	4	radioactive	radioactive	JJ
cord-006229-7yoilsho	5663	5	isotope	isotope	NN
cord-006229-7yoilsho	5663	6	-	-	HYPH
cord-006229-7yoilsho	5663	7	labelled	label	VBN
cord-006229-7yoilsho	5663	8	standards	standard	NNS
cord-006229-7yoilsho	5663	9	are	be	VBP
cord-006229-7yoilsho	5663	10	being	be	VBG
cord-006229-7yoilsho	5663	11	synthesized	synthesize	VBN
cord-006229-7yoilsho	5663	12	,	,	,
cord-006229-7yoilsho	5663	13	which	which	WDT
cord-006229-7yoilsho	5663	14	will	will	MD
cord-006229-7yoilsho	5663	15	be	be	VB
cord-006229-7yoilsho	5663	16	spiked	spike	VBN
cord-006229-7yoilsho	5663	17	into	into	IN
cord-006229-7yoilsho	5663	18	samples	sample	NNS
cord-006229-7yoilsho	5663	19	to	to	TO
cord-006229-7yoilsho	5663	20	account	account	VB
cord-006229-7yoilsho	5663	21	for	for	IN
cord-006229-7yoilsho	5663	22	technical	technical	JJ
cord-006229-7yoilsho	5663	23	variability	variability	NN
cord-006229-7yoilsho	5663	24	during	during	IN
cord-006229-7yoilsho	5663	25	sample	sample	NN
cord-006229-7yoilsho	5663	26	work	work	NN
cord-006229-7yoilsho	5663	27	-	-	HYPH
cord-006229-7yoilsho	5663	28	up	up	NN
cord-006229-7yoilsho	5663	29	and	and	CC
cord-006229-7yoilsho	5663	30	to	to	TO
cord-006229-7yoilsho	5663	31	improve	improve	VB
cord-006229-7yoilsho	5663	32	MS	MS	NNP
cord-006229-7yoilsho	5663	33	-	-	HYPH
cord-006229-7yoilsho	5663	34	based	base	VBN
cord-006229-7yoilsho	5663	35	quantitation	quantitation	NN
cord-006229-7yoilsho	5663	36	.	.	.
cord-006229-7yoilsho	5664	1	This	this	DT
cord-006229-7yoilsho	5664	2	procedure	procedure	NN
cord-006229-7yoilsho	5664	3	requires	require	VBZ
cord-006229-7yoilsho	5664	4	minimal	minimal	JJ
cord-006229-7yoilsho	5664	5	cellular	cellular	JJ
cord-006229-7yoilsho	5664	6	material	material	NN
cord-006229-7yoilsho	5664	7	and	and	CC
cord-006229-7yoilsho	5664	8	therefore	therefore	RB
cord-006229-7yoilsho	5664	9	should	should	MD
cord-006229-7yoilsho	5664	10	be	be	VB
cord-006229-7yoilsho	5664	11	transferred	transfer	VBN
cord-006229-7yoilsho	5664	12	to	to	IN
cord-006229-7yoilsho	5664	13	quantitation	quantitation	NN
cord-006229-7yoilsho	5664	14	of	of	IN
cord-006229-7yoilsho	5664	15	DNA	dna	NN
cord-006229-7yoilsho	5664	16	adducts	adduct	NNS
cord-006229-7yoilsho	5664	17	in	in	IN
cord-006229-7yoilsho	5664	18	human	human	JJ
cord-006229-7yoilsho	5664	19	blood	blood	NN
cord-006229-7yoilsho	5664	20	samples	sample	NNS
cord-006229-7yoilsho	5664	21	.	.	.
cord-006229-7yoilsho	5665	1	This	this	DT
cord-006229-7yoilsho	5665	2	will	will	MD
cord-006229-7yoilsho	5665	3	allow	allow	VB
cord-006229-7yoilsho	5665	4	to	to	TO
cord-006229-7yoilsho	5665	5	monitor	monitor	VB
cord-006229-7yoilsho	5665	6	DNA	dna	NN
cord-006229-7yoilsho	5665	7	adducts	adduct	NNS
cord-006229-7yoilsho	5665	8	as	as	IN
cord-006229-7yoilsho	5665	9	biomarkers	biomarker	NNS
cord-006229-7yoilsho	5665	10	of	of	IN
cord-006229-7yoilsho	5665	11	exposure	exposure	NN
cord-006229-7yoilsho	5665	12	in	in	IN
cord-006229-7yoilsho	5665	13	potential	potential	JJ
cord-006229-7yoilsho	5665	14	SMexposed	smexposed	JJ
cord-006229-7yoilsho	5665	15	victims	victim	NNS
cord-006229-7yoilsho	5665	16	as	as	RB
cord-006229-7yoilsho	5665	17	well	well	RB
cord-006229-7yoilsho	5665	18	as	as	IN
cord-006229-7yoilsho	5665	19	in	in	IN
cord-006229-7yoilsho	5665	20	mustard	mustard	NN
cord-006229-7yoilsho	5665	21	-	-	HYPH
cord-006229-7yoilsho	5665	22	based	base	VBN
cord-006229-7yoilsho	5665	23	chemotherapy	chemotherapy	NN
cord-006229-7yoilsho	5665	24	.	.	.
cord-006229-7yoilsho	5666	1	This	this	DT
cord-006229-7yoilsho	5666	2	method	method	NN
cord-006229-7yoilsho	5666	3	also	also	RB
cord-006229-7yoilsho	5666	4	sets	set	VBZ
cord-006229-7yoilsho	5666	5	a	a	DT
cord-006229-7yoilsho	5666	6	basis	basis	NN
cord-006229-7yoilsho	5666	7	to	to	TO
cord-006229-7yoilsho	5666	8	investigate	investigate	VB
cord-006229-7yoilsho	5666	9	specific	specific	JJ
cord-006229-7yoilsho	5666	10	mustard	mustard	NN
cord-006229-7yoilsho	5666	11	-	-	HYPH
cord-006229-7yoilsho	5666	12	induced	induce	VBN
cord-006229-7yoilsho	5666	13	DNA	dna	NN
cord-006229-7yoilsho	5666	14	repair	repair	NN
cord-006229-7yoilsho	5666	15	mechanisms	mechanism	NNS
cord-006229-7yoilsho	5666	16	and	and	CC
cord-006229-7yoilsho	5666	17	their	-PRON-	PRP$
cord-006229-7yoilsho	5666	18	cellular	cellular	JJ
cord-006229-7yoilsho	5666	19	consequences	consequence	NNS
cord-006229-7yoilsho	5666	20	.	.	.
cord-006229-7yoilsho	5667	1	The	the	DT
cord-006229-7yoilsho	5667	2	γH2AX	γH2AX	NNP
cord-006229-7yoilsho	5667	3	assay	assay	NN
cord-006229-7yoilsho	5667	4	vs.	vs.	IN
cord-006229-7yoilsho	5667	5	comet	comet	JJ
cord-006229-7yoilsho	5667	6	assay	assay	NN
cord-006229-7yoilsho	5667	7	for	for	IN
cord-006229-7yoilsho	5667	8	genotoxicity	genotoxicity	NN
cord-006229-7yoilsho	5667	9	testing	test	VBG
cord-006229-7yoilsho	5667	10	Universitätsmedizin	Universitätsmedizin	NNP
cord-006229-7yoilsho	5667	11	Mainz	Mainz	NNP
cord-006229-7yoilsho	5667	12	,	,	,
cord-006229-7yoilsho	5667	13	Institut	Institut	NNP
cord-006229-7yoilsho	5667	14	für	für	IN
cord-006229-7yoilsho	5667	15	Toxikologie	Toxikologie	NNP
cord-006229-7yoilsho	5667	16	,	,	,
cord-006229-7yoilsho	5667	17	Mainz	Mainz	NNP
cord-006229-7yoilsho	5667	18	,	,	,
cord-006229-7yoilsho	5668	1	Germany	Germany	NNP
cord-006229-7yoilsho	5668	2	DNA	DNA	NNP
cord-006229-7yoilsho	5668	3	damage	damage	NN
cord-006229-7yoilsho	5668	4	leads	lead	VBZ
cord-006229-7yoilsho	5668	5	to	to	IN
cord-006229-7yoilsho	5668	6	activation	activation	NN
cord-006229-7yoilsho	5668	7	of	of	IN
cord-006229-7yoilsho	5668	8	the	the	DT
cord-006229-7yoilsho	5668	9	cellular	cellular	JJ
cord-006229-7yoilsho	5668	10	DNA	dna	NN
cord-006229-7yoilsho	5668	11	damage	damage	NN
cord-006229-7yoilsho	5668	12	response	response	NN
cord-006229-7yoilsho	5668	13	(	(	-LRB-
cord-006229-7yoilsho	5668	14	DDR	DDR	NNP
cord-006229-7yoilsho	5668	15	)	)	-RRB-
cord-006229-7yoilsho	5668	16	.	.	.
cord-006229-7yoilsho	5669	1	This	this	DT
cord-006229-7yoilsho	5669	2	signalling	signal	VBG
cord-006229-7yoilsho	5669	3	network	network	NN
cord-006229-7yoilsho	5669	4	results	result	NNS
cord-006229-7yoilsho	5669	5	in	in	IN
cord-006229-7yoilsho	5669	6	activation	activation	NN
cord-006229-7yoilsho	5669	7	of	of	IN
cord-006229-7yoilsho	5669	8	various	various	JJ
cord-006229-7yoilsho	5669	9	DNA	dna	NN
cord-006229-7yoilsho	5669	10	repair	repair	NN
cord-006229-7yoilsho	5669	11	proteins	protein	NNS
cord-006229-7yoilsho	5669	12	and	and	CC
cord-006229-7yoilsho	5669	13	chromatin	chromatin	NN
cord-006229-7yoilsho	5669	14	structure	structure	NN
cord-006229-7yoilsho	5669	15	modulators	modulator	NNS
cord-006229-7yoilsho	5669	16	.	.	.
cord-006229-7yoilsho	5670	1	A	a	DT
cord-006229-7yoilsho	5670	2	frequent	frequent	JJ
cord-006229-7yoilsho	5670	3	manifestation	manifestation	NN
cord-006229-7yoilsho	5670	4	of	of	IN
cord-006229-7yoilsho	5670	5	DDR	DDR	NNP
cord-006229-7yoilsho	5670	6	is	be	VBZ
cord-006229-7yoilsho	5670	7	the	the	DT
cord-006229-7yoilsho	5670	8	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	5670	9	of	of	IN
cord-006229-7yoilsho	5670	10	histone	histone	NNP
cord-006229-7yoilsho	5670	11	2AX	2ax	CD
cord-006229-7yoilsho	5670	12	(	(	-LRB-
cord-006229-7yoilsho	5670	13	gH2AX	gH2AX	NNP
cord-006229-7yoilsho	5670	14	)	)	-RRB-
cord-006229-7yoilsho	5670	15	,	,	,
cord-006229-7yoilsho	5670	16	which	which	WDT
cord-006229-7yoilsho	5670	17	can	can	MD
cord-006229-7yoilsho	5670	18	be	be	VB
cord-006229-7yoilsho	5670	19	visualised	visualise	VBN
cord-006229-7yoilsho	5670	20	as	as	IN
cord-006229-7yoilsho	5670	21	gH2AX	gH2AX	NNP
cord-006229-7yoilsho	5670	22	foci	focus	NNS
cord-006229-7yoilsho	5670	23	by	by	IN
cord-006229-7yoilsho	5670	24	immunocytochemistry	immunocytochemistry	NNP
cord-006229-7yoilsho	5670	25	.	.	.
cord-006229-7yoilsho	5671	1	In	in	IN
cord-006229-7yoilsho	5671	2	the	the	DT
cord-006229-7yoilsho	5671	3	present	present	JJ
cord-006229-7yoilsho	5671	4	study	study	NN
cord-006229-7yoilsho	5671	5	,	,	,
cord-006229-7yoilsho	5671	6	we	-PRON-	PRP
cord-006229-7yoilsho	5671	7	tried	try	VBD
cord-006229-7yoilsho	5671	8	to	to	TO
cord-006229-7yoilsho	5671	9	assess	assess	VB
cord-006229-7yoilsho	5671	10	if	if	IN
cord-006229-7yoilsho	5671	11	gH2AX	gH2AX	NNP
cord-006229-7yoilsho	5671	12	is	be	VBZ
cord-006229-7yoilsho	5671	13	a	a	DT
cord-006229-7yoilsho	5671	14	reliable	reliable	JJ
cord-006229-7yoilsho	5671	15	biomarker	biomarker	NN
cord-006229-7yoilsho	5671	16	for	for	IN
cord-006229-7yoilsho	5671	17	detecting	detect	VBG
cord-006229-7yoilsho	5671	18	the	the	DT
cord-006229-7yoilsho	5671	19	cellular	cellular	JJ
cord-006229-7yoilsho	5671	20	response	response	NN
cord-006229-7yoilsho	5671	21	to	to	IN
cord-006229-7yoilsho	5671	22	DNA	dna	NN
cord-006229-7yoilsho	5671	23	damage	damage	NN
cord-006229-7yoilsho	5671	24	.	.	.
cord-006229-7yoilsho	5672	1	We	-PRON-	PRP
cord-006229-7yoilsho	5672	2	selected	select	VBD
cord-006229-7yoilsho	5672	3	14	14	CD
cord-006229-7yoilsho	5672	4	well	well	RB
cord-006229-7yoilsho	5672	5	-	-	HYPH
cord-006229-7yoilsho	5672	6	characterised	characterise	VBN
cord-006229-7yoilsho	5672	7	genotoxic	genotoxic	JJ
cord-006229-7yoilsho	5672	8	compounds	compound	NNS
cord-006229-7yoilsho	5672	9	and	and	CC
cord-006229-7yoilsho	5672	10	compared	compare	VBD
cord-006229-7yoilsho	5672	11	them	-PRON-	PRP
cord-006229-7yoilsho	5672	12	with	with	IN
cord-006229-7yoilsho	5672	13	10	10	CD
cord-006229-7yoilsho	5672	14	non	non	JJ
cord-006229-7yoilsho	5672	15	-	-	JJ
cord-006229-7yoilsho	5672	16	genotoxic	genotoxic	JJ
cord-006229-7yoilsho	5672	17	chemicals	chemical	NNS
cord-006229-7yoilsho	5672	18	in	in	IN
cord-006229-7yoilsho	5672	19	the	the	DT
cord-006229-7yoilsho	5672	20	wellcharacterised	wellcharacterise	VBN
cord-006229-7yoilsho	5672	21	CHO	CHO	NNP
cord-006229-7yoilsho	5672	22	cell	cell	NN
cord-006229-7yoilsho	5672	23	system	system	NN
cord-006229-7yoilsho	5672	24	.	.	.
cord-006229-7yoilsho	5673	1	We	-PRON-	PRP
cord-006229-7yoilsho	5673	2	measured	measure	VBD
cord-006229-7yoilsho	5673	3	quantitatively	quantitatively	RB
cord-006229-7yoilsho	5673	4	γH2AX	γH2AX	NNP
cord-006229-7yoilsho	5673	5	by	by	IN
cord-006229-7yoilsho	5673	6	manual	manual	JJ
cord-006229-7yoilsho	5673	7	and	and	CC
cord-006229-7yoilsho	5673	8	automatic	automatic	JJ
cord-006229-7yoilsho	5673	9	scoring	scoring	NN
cord-006229-7yoilsho	5673	10	of	of	IN
cord-006229-7yoilsho	5673	11	γH2AX	γH2AX	NNP
cord-006229-7yoilsho	5673	12	foci	foci	NN
cord-006229-7yoilsho	5673	13	,	,	,
cord-006229-7yoilsho	5673	14	and	and	CC
cord-006229-7yoilsho	5673	15	by	by	IN
cord-006229-7yoilsho	5673	16	flow	flow	NN
cord-006229-7yoilsho	5673	17	cytometry	cytometry	NN
cord-006229-7yoilsho	5673	18	counting	counting	NN
cord-006229-7yoilsho	5673	19	of	of	IN
cord-006229-7yoilsho	5673	20	γH2AX	γH2AX	NNP
cord-006229-7yoilsho	5673	21	positive	positive	JJ
cord-006229-7yoilsho	5673	22	cells	cell	NNS
cord-006229-7yoilsho	5673	23	.	.	.
cord-006229-7yoilsho	5674	1	The	the	DT
cord-006229-7yoilsho	5674	2	cytotoxicity	cytotoxicity	NN
cord-006229-7yoilsho	5674	3	dose	dose	NN
cord-006229-7yoilsho	5674	4	-	-	HYPH
cord-006229-7yoilsho	5674	5	response	response	NN
cord-006229-7yoilsho	5674	6	was	be	VBD
cord-006229-7yoilsho	5674	7	determined	determine	VBN
cord-006229-7yoilsho	5674	8	by	by	IN
cord-006229-7yoilsho	5674	9	the	the	DT
cord-006229-7yoilsho	5674	10	MTT	MTT	NNP
cord-006229-7yoilsho	5674	11	cell	cell	NN
cord-006229-7yoilsho	5674	12	proliferation	proliferation	NN
cord-006229-7yoilsho	5674	13	/	/	SYM
cord-006229-7yoilsho	5674	14	viability	viability	NN
cord-006229-7yoilsho	5674	15	assay	assay	NN
cord-006229-7yoilsho	5674	16	.	.	.
cord-006229-7yoilsho	5675	1	We	-PRON-	PRP
cord-006229-7yoilsho	5675	2	show	show	VBP
cord-006229-7yoilsho	5675	3	that	that	IN
cord-006229-7yoilsho	5675	4	a	a	LS
cord-006229-7yoilsho	5675	5	)	)	-RRB-
cord-006229-7yoilsho	5675	6	all	all	DT
cord-006229-7yoilsho	5675	7	genotoxic	genotoxic	JJ
cord-006229-7yoilsho	5675	8	agents	agent	NNS
cord-006229-7yoilsho	5675	9	were	be	VBD
cord-006229-7yoilsho	5675	10	able	able	JJ
cord-006229-7yoilsho	5675	11	to	to	TO
cord-006229-7yoilsho	5675	12	induce	induce	VB
cord-006229-7yoilsho	5675	13	dose	dose	NN
cord-006229-7yoilsho	5675	14	-	-	HYPH
cord-006229-7yoilsho	5675	15	dependently	dependently	RB
cord-006229-7yoilsho	5675	16	γH2AX	γH2AX	NNP
cord-006229-7yoilsho	5675	17	in	in	IN
cord-006229-7yoilsho	5675	18	the	the	DT
cord-006229-7yoilsho	5675	19	cytotoxic	cytotoxic	JJ
cord-006229-7yoilsho	5675	20	range	range	NN
cord-006229-7yoilsho	5675	21	whereas	whereas	IN
cord-006229-7yoilsho	5675	22	no	no	DT
cord-006229-7yoilsho	5675	23	induction	induction	NN
cord-006229-7yoilsho	5675	24	was	be	VBD
cord-006229-7yoilsho	5675	25	observed	observe	VBN
cord-006229-7yoilsho	5675	26	after	after	IN
cord-006229-7yoilsho	5675	27	treatment	treatment	NN
cord-006229-7yoilsho	5675	28	with	with	IN
cord-006229-7yoilsho	5675	29	non	non	JJ
cord-006229-7yoilsho	5675	30	-	-	JJ
cord-006229-7yoilsho	5675	31	genotoxicants	genotoxicant	NNS
cord-006229-7yoilsho	5675	32	;	;	:
cord-006229-7yoilsho	5675	33	b	b	LS
cord-006229-7yoilsho	5675	34	)	)	-RRB-
cord-006229-7yoilsho	5675	35	manual	manual	JJ
cord-006229-7yoilsho	5675	36	scoring	scoring	NN
cord-006229-7yoilsho	5675	37	of	of	IN
cord-006229-7yoilsho	5675	38	γH2AX	γH2AX	NNP
cord-006229-7yoilsho	5675	39	foci	foci	NN
cord-006229-7yoilsho	5675	40	and	and	CC
cord-006229-7yoilsho	5675	41	automated	automated	JJ
cord-006229-7yoilsho	5675	42	scoring	scoring	NN
cord-006229-7yoilsho	5675	43	gave	give	VBD
cord-006229-7yoilsho	5675	44	similar	similar	JJ
cord-006229-7yoilsho	5675	45	results	result	NNS
cord-006229-7yoilsho	5675	46	,	,	,
cord-006229-7yoilsho	5675	47	with	with	IN
cord-006229-7yoilsho	5675	48	the	the	DT
cord-006229-7yoilsho	5675	49	automated	automate	VBN
cord-006229-7yoilsho	5675	50	scoring	scoring	NN
cord-006229-7yoilsho	5675	51	being	be	VBG
cord-006229-7yoilsho	5675	52	faster	fast	JJR
cord-006229-7yoilsho	5675	53	and	and	CC
cord-006229-7yoilsho	5675	54	more	more	RBR
cord-006229-7yoilsho	5675	55	reproducible	reproducible	JJ
cord-006229-7yoilsho	5675	56	;	;	:
cord-006229-7yoilsho	5675	57	c	c	NN
cord-006229-7yoilsho	5675	58	)	)	-RRB-
cord-006229-7yoilsho	5675	59	data	datum	NNS
cord-006229-7yoilsho	5675	60	obtained	obtain	VBN
cord-006229-7yoilsho	5675	61	by	by	IN
cord-006229-7yoilsho	5675	62	foci	foci	NN
cord-006229-7yoilsho	5675	63	counting	counting	NN
cord-006229-7yoilsho	5675	64	and	and	CC
cord-006229-7yoilsho	5675	65	FACS	FACS	NNP
cord-006229-7yoilsho	5675	66	analysis	analysis	NN
cord-006229-7yoilsho	5675	67	of	of	IN
cord-006229-7yoilsho	5675	68	γH2AX	γH2AX	NNP
cord-006229-7yoilsho	5675	69	positive	positive	JJ
cord-006229-7yoilsho	5675	70	cells	cell	NNS
cord-006229-7yoilsho	5675	71	showed	show	VBD
cord-006229-7yoilsho	5675	72	a	a	DT
cord-006229-7yoilsho	5675	73	significant	significant	JJ
cord-006229-7yoilsho	5675	74	correlation	correlation	NN
cord-006229-7yoilsho	5675	75	.	.	.
cord-006229-7yoilsho	5676	1	Further	further	RB
cord-006229-7yoilsho	5676	2	we	-PRON-	PRP
cord-006229-7yoilsho	5676	3	compared	compare	VBD
cord-006229-7yoilsho	5676	4	DNA	dna	NN
cord-006229-7yoilsho	5676	5	damage	damage	NN
cord-006229-7yoilsho	5676	6	induced	induce	VBN
cord-006229-7yoilsho	5676	7	by	by	IN
cord-006229-7yoilsho	5676	8	4	4	CD
cord-006229-7yoilsho	5676	9	selected	select	VBN
cord-006229-7yoilsho	5676	10	genotoxins	genotoxin	NNS
cord-006229-7yoilsho	5676	11	at	at	IN
cord-006229-7yoilsho	5676	12	the	the	DT
cord-006229-7yoilsho	5676	13	time	time	NN
cord-006229-7yoilsho	5676	14	-	-	HYPH
cord-006229-7yoilsho	5676	15	points	point	NNS
cord-006229-7yoilsho	5676	16	using	use	VBG
cord-006229-7yoilsho	5676	17	the	the	DT
cord-006229-7yoilsho	5676	18	alkaline	alkaline	JJ
cord-006229-7yoilsho	5676	19	and	and	CC
cord-006229-7yoilsho	5676	20	neutral	neutral	JJ
cord-006229-7yoilsho	5676	21	comet	comet	JJ
cord-006229-7yoilsho	5676	22	assay	assay	NN
cord-006229-7yoilsho	5676	23	.	.	.
cord-006229-7yoilsho	5677	1	Significant	significant	JJ
cord-006229-7yoilsho	5677	2	correlation	correlation	NN
cord-006229-7yoilsho	5677	3	with	with	IN
cord-006229-7yoilsho	5677	4	the	the	DT
cord-006229-7yoilsho	5677	5	alkaline	alkaline	JJ
cord-006229-7yoilsho	5677	6	and	and	CC
cord-006229-7yoilsho	5677	7	neutral	neutral	JJ
cord-006229-7yoilsho	5677	8	comet	comet	JJ
cord-006229-7yoilsho	5677	9	assay	assay	NN
cord-006229-7yoilsho	5677	10	was	be	VBD
cord-006229-7yoilsho	5677	11	observed	observe	VBN
cord-006229-7yoilsho	5677	12	for	for	IN
cord-006229-7yoilsho	5677	13	some	some	DT
cord-006229-7yoilsho	5677	14	but	but	CC
cord-006229-7yoilsho	5677	15	not	not	RB
cord-006229-7yoilsho	5677	16	all	all	DT
cord-006229-7yoilsho	5677	17	genotoxins	genotoxin	NNS
cord-006229-7yoilsho	5677	18	and	and	CC
cord-006229-7yoilsho	5677	19	,	,	,
cord-006229-7yoilsho	5677	20	predominantly	predominantly	RB
cord-006229-7yoilsho	5677	21	,	,	,
cord-006229-7yoilsho	5677	22	at	at	IN
cord-006229-7yoilsho	5677	23	earlier	early	JJR
cord-006229-7yoilsho	5677	24	time	time	NN
cord-006229-7yoilsho	5677	25	points	point	NNS
cord-006229-7yoilsho	5677	26	.	.	.
cord-006229-7yoilsho	5678	1	We	-PRON-	PRP
cord-006229-7yoilsho	5678	2	suggest	suggest	VBP
cord-006229-7yoilsho	5678	3	that	that	IN
cord-006229-7yoilsho	5678	4	comet	comet	NN
cord-006229-7yoilsho	5678	5	assays	assay	NNS
cord-006229-7yoilsho	5678	6	detect	detect	VBP
cord-006229-7yoilsho	5678	7	mainly	mainly	RB
cord-006229-7yoilsho	5678	8	primary	primary	JJ
cord-006229-7yoilsho	5678	9	DNA	dna	NN
cord-006229-7yoilsho	5678	10	damage	damage	NN
cord-006229-7yoilsho	5678	11	,	,	,
cord-006229-7yoilsho	5678	12	whereas	whereas	IN
cord-006229-7yoilsho	5678	13	γH2AX	γH2AX	NNP
cord-006229-7yoilsho	5678	14	assay	assay	NN
cord-006229-7yoilsho	5678	15	detects	detect	VBZ
cord-006229-7yoilsho	5678	16	a	a	DT
cord-006229-7yoilsho	5678	17	specific	specific	JJ
cord-006229-7yoilsho	5678	18	response	response	NN
cord-006229-7yoilsho	5678	19	to	to	IN
cord-006229-7yoilsho	5678	20	DNA	dna	NN
cord-006229-7yoilsho	5678	21	damage	damage	NN
cord-006229-7yoilsho	5678	22	which	which	WDT
cord-006229-7yoilsho	5678	23	can	can	MD
cord-006229-7yoilsho	5678	24	persist	persist	VB
cord-006229-7yoilsho	5678	25	longer	long	RBR
cord-006229-7yoilsho	5678	26	.	.	.
cord-006229-7yoilsho	5679	1	The	the	DT
cord-006229-7yoilsho	5679	2	γH2AX	γH2AX	NNP
cord-006229-7yoilsho	5679	3	foci	foci	NN
cord-006229-7yoilsho	5679	4	and	and	CC
cord-006229-7yoilsho	5679	5	flow	flow	NN
cord-006229-7yoilsho	5679	6	-	-	HYPH
cord-006229-7yoilsho	5679	7	cytometry	cytometry	NN
cord-006229-7yoilsho	5679	8	assays	assay	NNS
cord-006229-7yoilsho	5679	9	allow	allow	VBP
cord-006229-7yoilsho	5679	10	for	for	IN
cord-006229-7yoilsho	5679	11	a	a	DT
cord-006229-7yoilsho	5679	12	rapid	rapid	JJ
cord-006229-7yoilsho	5679	13	and	and	CC
cord-006229-7yoilsho	5679	14	reliable	reliable	JJ
cord-006229-7yoilsho	5679	15	determination	determination	NN
cord-006229-7yoilsho	5679	16	of	of	IN
cord-006229-7yoilsho	5679	17	genetic	genetic	JJ
cord-006229-7yoilsho	5679	18	damage	damage	NN
cord-006229-7yoilsho	5679	19	in	in	IN
cord-006229-7yoilsho	5679	20	mammalian	mammalian	JJ
cord-006229-7yoilsho	5679	21	cells	cell	NNS
cord-006229-7yoilsho	5679	22	and	and	CC
cord-006229-7yoilsho	5679	23	can	can	MD
cord-006229-7yoilsho	5679	24	be	be	VB
cord-006229-7yoilsho	5679	25	used	use	VBN
cord-006229-7yoilsho	5679	26	as	as	IN
cord-006229-7yoilsho	5679	27	additional	additional	JJ
cord-006229-7yoilsho	5679	28	genotoxicity	genotoxicity	NN
cord-006229-7yoilsho	5679	29	assays	assay	NNS
cord-006229-7yoilsho	5679	30	.	.	.
cord-006229-7yoilsho	5680	1	Available	available	JJ
cord-006229-7yoilsho	5680	2	in	in	IN
cord-006229-7yoilsho	5680	3	vitro	vitro	FW
cord-006229-7yoilsho	5680	4	methods	method	NNS
cord-006229-7yoilsho	5680	5	to	to	TO
cord-006229-7yoilsho	5680	6	investigate	investigate	VB
cord-006229-7yoilsho	5680	7	the	the	DT
cord-006229-7yoilsho	5680	8	genotoxic	genotoxic	JJ
cord-006229-7yoilsho	5680	9	potential	potential	NN
cord-006229-7yoilsho	5680	10	of	of	IN
cord-006229-7yoilsho	5680	11	drugs	drug	NNS
cord-006229-7yoilsho	5680	12	fall	fall	VBP
cord-006229-7yoilsho	5680	13	short	short	RB
cord-006229-7yoilsho	5680	14	of	of	IN
cord-006229-7yoilsho	5680	15	throughput	throughput	NN
cord-006229-7yoilsho	5680	16	,	,	,
cord-006229-7yoilsho	5680	17	specificity	specificity	NN
cord-006229-7yoilsho	5680	18	and	and	CC
cord-006229-7yoilsho	5680	19	mode	mode	NN
cord-006229-7yoilsho	5680	20	of	of	IN
cord-006229-7yoilsho	5680	21	action	action	NN
cord-006229-7yoilsho	5680	22	information	information	NN
cord-006229-7yoilsho	5680	23	.	.	.
cord-006229-7yoilsho	5681	1	A	a	DT
cord-006229-7yoilsho	5681	2	set	set	NN
cord-006229-7yoilsho	5681	3	of	of	IN
cord-006229-7yoilsho	5681	4	mechanistic	mechanistic	JJ
cord-006229-7yoilsho	5681	5	biomarkers	biomarker	NNS
cord-006229-7yoilsho	5681	6	for	for	IN
cord-006229-7yoilsho	5681	7	clastogenic	clastogenic	NNP
cord-006229-7yoilsho	5681	8	,	,	,
cord-006229-7yoilsho	5681	9	aneugenic	aneugenic	JJ
cord-006229-7yoilsho	5681	10	or	or	CC
cord-006229-7yoilsho	5681	11	apoptotic	apoptotic	JJ
cord-006229-7yoilsho	5681	12	effects	effect	NNS
cord-006229-7yoilsho	5681	13	may	may	MD
cord-006229-7yoilsho	5681	14	help	help	VB
cord-006229-7yoilsho	5681	15	to	to	TO
cord-006229-7yoilsho	5681	16	overcome	overcome	VB
cord-006229-7yoilsho	5681	17	these	these	DT
cord-006229-7yoilsho	5681	18	limitations	limitation	NNS
cord-006229-7yoilsho	5681	19	.	.	.
cord-006229-7yoilsho	5682	1	Thus	thus	RB
cord-006229-7yoilsho	5682	2	,	,	,
cord-006229-7yoilsho	5682	3	a	a	DT
cord-006229-7yoilsho	5682	4	staining	stain	VBG
cord-006229-7yoilsho	5682	5	assay	assay	NN
cord-006229-7yoilsho	5682	6	amenable	amenable	JJ
cord-006229-7yoilsho	5682	7	to	to	TO
cord-006229-7yoilsho	5682	8	flow	flow	VB
cord-006229-7yoilsho	5682	9	cytometric	cytometric	NNP
cord-006229-7yoilsho	5682	10	analysis	analysis	NN
cord-006229-7yoilsho	5682	11	is	be	VBZ
cord-006229-7yoilsho	5682	12	being	be	VBG
cord-006229-7yoilsho	5682	13	developed	develop	VBN
cord-006229-7yoilsho	5682	14	by	by	IN
cord-006229-7yoilsho	5682	15	Litron	Litron	NNP
cord-006229-7yoilsho	5682	16	Laboratories	Laboratories	NNP
cord-006229-7yoilsho	5682	17	,	,	,
cord-006229-7yoilsho	5682	18	Rochester	Rochester	NNP
cord-006229-7yoilsho	5682	19	,	,	,
cord-006229-7yoilsho	5682	20	NY	NY	NNP
cord-006229-7yoilsho	5682	21	,	,	,
cord-006229-7yoilsho	5682	22	supported	support	VBN
cord-006229-7yoilsho	5682	23	by	by	IN
cord-006229-7yoilsho	5682	24	international	international	JJ
cord-006229-7yoilsho	5682	25	collaborators	collaborator	NNS
cord-006229-7yoilsho	5682	26	.	.	.
cord-006229-7yoilsho	5683	1	The	the	DT
cord-006229-7yoilsho	5683	2	experimental	experimental	JJ
cord-006229-7yoilsho	5683	3	design	design	NN
cord-006229-7yoilsho	5683	4	of	of	IN
cord-006229-7yoilsho	5683	5	this	this	DT
cord-006229-7yoilsho	5683	6	assay	assay	NN
cord-006229-7yoilsho	5683	7	consists	consist	VBZ
cord-006229-7yoilsho	5683	8	of	of	IN
cord-006229-7yoilsho	5683	9	3	3	CD
cord-006229-7yoilsho	5683	10	stages	stage	NNS
cord-006229-7yoilsho	5683	11	.	.	.
cord-006229-7yoilsho	5684	1	The	the	DT
cord-006229-7yoilsho	5684	2	objective	objective	NN
cord-006229-7yoilsho	5684	3	of	of	IN
cord-006229-7yoilsho	5684	4	this	this	DT
cord-006229-7yoilsho	5684	5	work	work	NN
cord-006229-7yoilsho	5684	6	is	be	VBZ
cord-006229-7yoilsho	5684	7	the	the	DT
cord-006229-7yoilsho	5684	8	evaluation	evaluation	NN
cord-006229-7yoilsho	5684	9	of	of	IN
cord-006229-7yoilsho	5684	10	this	this	DT
cord-006229-7yoilsho	5684	11	assay	assay	NN
cord-006229-7yoilsho	5684	12	in	in	IN
cord-006229-7yoilsho	5684	13	the	the	DT
cord-006229-7yoilsho	5684	14	laboratories	laboratory	NNS
cord-006229-7yoilsho	5684	15	of	of	IN
cord-006229-7yoilsho	5684	16	Bayer	Bayer	NNP
cord-006229-7yoilsho	5684	17	Pharma	Pharma	NNP
cord-006229-7yoilsho	5684	18	AG	AG	NNP
cord-006229-7yoilsho	5684	19	.	.	.
cord-006229-7yoilsho	5685	1	The	the	DT
cord-006229-7yoilsho	5685	2	biomarkers	biomarker	NNS
cord-006229-7yoilsho	5685	3	covered	cover	VBN
cord-006229-7yoilsho	5685	4	by	by	IN
cord-006229-7yoilsho	5685	5	the	the	DT
cord-006229-7yoilsho	5685	6	assay	assay	NN
cord-006229-7yoilsho	5685	7	are	be	VBP
cord-006229-7yoilsho	5685	8	associated	associate	VBN
cord-006229-7yoilsho	5685	9	with	with	IN
cord-006229-7yoilsho	5685	10	DNA	dna	NN
cord-006229-7yoilsho	5685	11	damage	damage	NN
cord-006229-7yoilsho	5685	12	response	response	NN
cord-006229-7yoilsho	5685	13	pathways	pathway	NNS
cord-006229-7yoilsho	5685	14	that	that	WDT
cord-006229-7yoilsho	5685	15	have	have	VBP
cord-006229-7yoilsho	5685	16	potential	potential	NN
cord-006229-7yoilsho	5685	17	for	for	IN
cord-006229-7yoilsho	5685	18	class	class	NN
cord-006229-7yoilsho	5685	19	discrimination	discrimination	NN
cord-006229-7yoilsho	5685	20	(	(	-LRB-
cord-006229-7yoilsho	5685	21	clastogen	clastogen	NNP
cord-006229-7yoilsho	5685	22	/	/	SYM
cord-006229-7yoilsho	5685	23	aneugen	aneugen	NNP
cord-006229-7yoilsho	5685	24	/	/	SYM
cord-006229-7yoilsho	5685	25	cytotoxicant	cytotoxicant	NNP
cord-006229-7yoilsho	5685	26	)	)	-RRB-
cord-006229-7yoilsho	5685	27	of	of	IN
cord-006229-7yoilsho	5685	28	in	in	FW
cord-006229-7yoilsho	5685	29	vitro	vitro	FW
cord-006229-7yoilsho	5685	30	genotoxicants	genotoxicant	NNS
cord-006229-7yoilsho	5685	31	:	:	:
cord-006229-7yoilsho	5686	1	DNA	DNA	NNP
cord-006229-7yoilsho	5686	2	double	double	JJ
cord-006229-7yoilsho	5686	3	strand	strand	NN
cord-006229-7yoilsho	5686	4	breaks	break	NNS
cord-006229-7yoilsho	5686	5	(	(	-LRB-
cord-006229-7yoilsho	5686	6	γH2AX	γH2AX	NNP
cord-006229-7yoilsho	5686	7	)	)	-RRB-
cord-006229-7yoilsho	5686	8	,	,	,
cord-006229-7yoilsho	5686	9	nuclear	nuclear	JJ
cord-006229-7yoilsho	5686	10	division	division	NN
cord-006229-7yoilsho	5686	11	(	(	-LRB-
cord-006229-7yoilsho	5686	12	phospho	phospho	NNP
cord-006229-7yoilsho	5686	13	-	-	HYPH
cord-006229-7yoilsho	5686	14	H3	H3	NNP
cord-006229-7yoilsho	5686	15	,	,	,
cord-006229-7yoilsho	5686	16	DNA	dna	NN
cord-006229-7yoilsho	5686	17	content	content	NN
cord-006229-7yoilsho	5686	18	)	)	-RRB-
cord-006229-7yoilsho	5686	19	,	,	,
cord-006229-7yoilsho	5686	20	apoptosis	apoptosis	NN
cord-006229-7yoilsho	5686	21	(	(	-LRB-
cord-006229-7yoilsho	5686	22	cleaved	cleave	VBN
cord-006229-7yoilsho	5686	23	PARP	PARP	NNP
cord-006229-7yoilsho	5686	24	)	)	-RRB-
cord-006229-7yoilsho	5686	25	.	.	.
cord-006229-7yoilsho	5687	1	Based	base	VBN
cord-006229-7yoilsho	5687	2	on	on	IN
cord-006229-7yoilsho	5687	3	the	the	DT
cord-006229-7yoilsho	5687	4	pilot	pilot	NN
cord-006229-7yoilsho	5687	5	work	work	NN
cord-006229-7yoilsho	5687	6	at	at	IN
cord-006229-7yoilsho	5687	7	Litron	Litron	NNP
cord-006229-7yoilsho	5687	8	Laboratories	Laboratories	NNP
cord-006229-7yoilsho	5687	9	,	,	,
cord-006229-7yoilsho	5687	10	TK6	tk6	NN
cord-006229-7yoilsho	5687	11	cells	cell	NNS
cord-006229-7yoilsho	5687	12	were	be	VBD
cord-006229-7yoilsho	5687	13	introduced	introduce	VBN
cord-006229-7yoilsho	5687	14	to	to	IN
cord-006229-7yoilsho	5687	15	the	the	DT
cord-006229-7yoilsho	5687	16	Genetic	Genetic	NNP
cord-006229-7yoilsho	5687	17	Toxicology	Toxicology	NNP
cord-006229-7yoilsho	5687	18	of	of	IN
cord-006229-7yoilsho	5687	19	Bayer	Bayer	NNP
cord-006229-7yoilsho	5687	20	Pharma	Pharma	NNP
cord-006229-7yoilsho	5687	21	AG	AG	NNP
cord-006229-7yoilsho	5687	22	.	.	.
cord-006229-7yoilsho	5688	1	Cells	cell	NNS
cord-006229-7yoilsho	5688	2	were	be	VBD
cord-006229-7yoilsho	5688	3	exposed	expose	VBN
cord-006229-7yoilsho	5688	4	for	for	IN
cord-006229-7yoilsho	5688	5	4	4	CD
cord-006229-7yoilsho	5688	6	and	and	CC
cord-006229-7yoilsho	5688	7	24	24	CD
cord-006229-7yoilsho	5688	8	hrs	hrs	NN
cord-006229-7yoilsho	5688	9	in	in	IN
cord-006229-7yoilsho	5688	10	triplicates	triplicate	NNS
cord-006229-7yoilsho	5688	11	on	on	IN
cord-006229-7yoilsho	5688	12	a	a	DT
cord-006229-7yoilsho	5688	13	96	96	CD
cord-006229-7yoilsho	5688	14	microwell	microwell	JJ
cord-006229-7yoilsho	5688	15	plate	plate	NN
cord-006229-7yoilsho	5688	16	to	to	IN
cord-006229-7yoilsho	5688	17	one	one	CD
cord-006229-7yoilsho	5688	18	reference	reference	NN
cord-006229-7yoilsho	5688	19	clastogen	clastogen	NNP
cord-006229-7yoilsho	5688	20	(	(	-LRB-
cord-006229-7yoilsho	5688	21	etoposide	etoposide	RB
cord-006229-7yoilsho	5688	22	,	,	,
cord-006229-7yoilsho	5688	23	ETO	ETO	NNP
cord-006229-7yoilsho	5688	24	)	)	-RRB-
cord-006229-7yoilsho	5688	25	,	,	,
cord-006229-7yoilsho	5688	26	aneugen	aneugen	NNP
cord-006229-7yoilsho	5688	27	(	(	-LRB-
cord-006229-7yoilsho	5688	28	vinblastine	vinblastine	NN
cord-006229-7yoilsho	5688	29	,	,	,
cord-006229-7yoilsho	5688	30	VB	VB	NNP
cord-006229-7yoilsho	5688	31	)	)	-RRB-
cord-006229-7yoilsho	5688	32	and	and	CC
cord-006229-7yoilsho	5688	33	cytotoxicant	cytotoxicant	JJ
cord-006229-7yoilsho	5688	34	(	(	-LRB-
cord-006229-7yoilsho	5688	35	carbonyl	carbonyl	NNP
cord-006229-7yoilsho	5688	36	cyanide	cyanide	NN
cord-006229-7yoilsho	5688	37	3-chlorophenylhydrazone	3-chlorophenylhydrazone	CD
cord-006229-7yoilsho	5688	38	,	,	,
cord-006229-7yoilsho	5688	39	CCCP	CCCP	NNP
cord-006229-7yoilsho	5688	40	)	)	-RRB-
cord-006229-7yoilsho	5688	41	.	.	.
cord-006229-7yoilsho	5689	1	After	after	IN
cord-006229-7yoilsho	5689	2	staining	stain	VBG
cord-006229-7yoilsho	5689	3	,	,	,
cord-006229-7yoilsho	5689	4	the	the	DT
cord-006229-7yoilsho	5689	5	samples	sample	NNS
cord-006229-7yoilsho	5689	6	were	be	VBD
cord-006229-7yoilsho	5689	7	analyzed	analyze	VBN
cord-006229-7yoilsho	5689	8	with	with	IN
cord-006229-7yoilsho	5689	9	the	the	DT
cord-006229-7yoilsho	5689	10	flow	flow	NN
cord-006229-7yoilsho	5689	11	cytometer	cytometer	NN
cord-006229-7yoilsho	5689	12	BD	BD	NNP
cord-006229-7yoilsho	5689	13	Accuri	Accuri	NNP
cord-006229-7yoilsho	5689	14	C6	C6	NNP
cord-006229-7yoilsho	5689	15	(	(	-LRB-
cord-006229-7yoilsho	5689	16	BD	BD	NNP
cord-006229-7yoilsho	5689	17	Biosciences	Biosciences	NNP
cord-006229-7yoilsho	5689	18	,	,	,
cord-006229-7yoilsho	5689	19	Heidelberg	Heidelberg	NNP
cord-006229-7yoilsho	5689	20	,	,	,
cord-006229-7yoilsho	5689	21	Germany	Germany	NNP
cord-006229-7yoilsho	5689	22	)	)	-RRB-
cord-006229-7yoilsho	5689	23	.	.	.
cord-006229-7yoilsho	5690	1	The	the	DT
cord-006229-7yoilsho	5690	2	reference	reference	NN
cord-006229-7yoilsho	5690	3	substances	substance	NNS
cord-006229-7yoilsho	5690	4	yielded	yield	VBD
cord-006229-7yoilsho	5690	5	the	the	DT
cord-006229-7yoilsho	5690	6	responses	response	NNS
cord-006229-7yoilsho	5690	7	expected	expect	VBN
cord-006229-7yoilsho	5690	8	from	from	IN
cord-006229-7yoilsho	5690	9	the	the	DT
cord-006229-7yoilsho	5690	10	pilot	pilot	NN
cord-006229-7yoilsho	5690	11	study	study	NN
cord-006229-7yoilsho	5690	12	at	at	IN
cord-006229-7yoilsho	5690	13	Litron	Litron	NNP
cord-006229-7yoilsho	5690	14	Laboratories	Laboratories	NNP
cord-006229-7yoilsho	5690	15	:	:	:
cord-006229-7yoilsho	5690	16	VB	VB	NNP
cord-006229-7yoilsho	5690	17	showed	show	VBD
cord-006229-7yoilsho	5690	18	distinct	distinct	JJ
cord-006229-7yoilsho	5690	19	increases	increase	NNS
cord-006229-7yoilsho	5690	20	of	of	IN
cord-006229-7yoilsho	5690	21	phospho	phospho	NN
cord-006229-7yoilsho	5690	22	-	-	HYPH
cord-006229-7yoilsho	5690	23	H3	H3	NNP
cord-006229-7yoilsho	5690	24	events	event	NNS
cord-006229-7yoilsho	5690	25	at	at	IN
cord-006229-7yoilsho	5690	26	4	4	CD
cord-006229-7yoilsho	5690	27	and	and	CC
cord-006229-7yoilsho	5690	28	24	24	CD
cord-006229-7yoilsho	5690	29	hrs	hrs	NN
cord-006229-7yoilsho	5690	30	and	and	CC
cord-006229-7yoilsho	5690	31	polyploidy	polyploidy	NN
cord-006229-7yoilsho	5690	32	at	at	IN
cord-006229-7yoilsho	5690	33	24	24	CD
cord-006229-7yoilsho	5690	34	hrs	hrs	NN
cord-006229-7yoilsho	5690	35	time	time	NN
cord-006229-7yoilsho	5690	36	point	point	NN
cord-006229-7yoilsho	5690	37	.	.	.
cord-006229-7yoilsho	5691	1	ETO	ETO	NNP
cord-006229-7yoilsho	5691	2	induced	induce	VBD
cord-006229-7yoilsho	5691	3	a	a	DT
cord-006229-7yoilsho	5691	4	clear	clear	JJ
cord-006229-7yoilsho	5691	5	increase	increase	NN
cord-006229-7yoilsho	5691	6	of	of	IN
cord-006229-7yoilsho	5691	7	yH2AX	yH2AX	NNP
cord-006229-7yoilsho	5691	8	with	with	IN
cord-006229-7yoilsho	5691	9	a	a	DT
cord-006229-7yoilsho	5691	10	simultaneous	simultaneous	JJ
cord-006229-7yoilsho	5691	11	reduction	reduction	NN
cord-006229-7yoilsho	5691	12	of	of	IN
cord-006229-7yoilsho	5691	13	phospho	phospho	NNP
cord-006229-7yoilsho	5691	14	-	-	HYPH
cord-006229-7yoilsho	5691	15	H3	H3	NNP
cord-006229-7yoilsho	5691	16	at	at	IN
cord-006229-7yoilsho	5691	17	4	4	CD
cord-006229-7yoilsho	5691	18	and	and	CC
cord-006229-7yoilsho	5691	19	24	24	CD
cord-006229-7yoilsho	5691	20	hrs	hrs	NN
cord-006229-7yoilsho	5691	21	.	.	.
cord-006229-7yoilsho	5692	1	Finally	finally	RB
cord-006229-7yoilsho	5692	2	,	,	,
cord-006229-7yoilsho	5692	3	CCCP	CCCP	NNP
cord-006229-7yoilsho	5692	4	caused	cause	VBD
cord-006229-7yoilsho	5692	5	a	a	DT
cord-006229-7yoilsho	5692	6	reduction	reduction	NN
cord-006229-7yoilsho	5692	7	of	of	IN
cord-006229-7yoilsho	5692	8	phospho	phospho	NNP
cord-006229-7yoilsho	5692	9	-	-	HYPH
cord-006229-7yoilsho	5692	10	H3	H3	NNP
cord-006229-7yoilsho	5692	11	events	event	NNS
cord-006229-7yoilsho	5692	12	,	,	,
cord-006229-7yoilsho	5692	13	increased	increase	VBD
cord-006229-7yoilsho	5692	14	cleaved	cleave	VBN
cord-006229-7yoilsho	5692	15	PARP	PARP	NNP
cord-006229-7yoilsho	5692	16	events	event	NNS
cord-006229-7yoilsho	5692	17	and	and	CC
cord-006229-7yoilsho	5692	18	did	do	VBD
cord-006229-7yoilsho	5692	19	not	not	RB
cord-006229-7yoilsho	5692	20	influence	influence	VB
cord-006229-7yoilsho	5692	21	γH2AX	γH2AX	NNP
cord-006229-7yoilsho	5692	22	.	.	.
cord-006229-7yoilsho	5693	1	Moreover	moreover	RB
cord-006229-7yoilsho	5693	2	,	,	,
cord-006229-7yoilsho	5693	3	benchmarking	benchmarke	VBG
cord-006229-7yoilsho	5693	4	experiments	experiment	NNS
cord-006229-7yoilsho	5693	5	under	under	IN
cord-006229-7yoilsho	5693	6	pilot	pilot	NN
cord-006229-7yoilsho	5693	7	work	work	NN
cord-006229-7yoilsho	5693	8	conditions	condition	NNS
cord-006229-7yoilsho	5693	9	were	be	VBD
cord-006229-7yoilsho	5693	10	performed	perform	VBN
cord-006229-7yoilsho	5693	11	with	with	IN
cord-006229-7yoilsho	5693	12	high	high	JJ
cord-006229-7yoilsho	5693	13	content	content	NN
cord-006229-7yoilsho	5693	14	imaging	imaging	NN
cord-006229-7yoilsho	5693	15	analysis	analysis	NN
cord-006229-7yoilsho	5693	16	.	.	.
cord-006229-7yoilsho	5694	1	We	-PRON-	PRP
cord-006229-7yoilsho	5694	2	compared	compare	VBD
cord-006229-7yoilsho	5694	3	yH2AX	yH2AX	NNP
cord-006229-7yoilsho	5694	4	and	and	CC
cord-006229-7yoilsho	5694	5	phsopho	phsopho	NN
cord-006229-7yoilsho	5694	6	-	-	HYPH
cord-006229-7yoilsho	5694	7	H3	H3	NNP
cord-006229-7yoilsho	5694	8	pilot	pilot	NN
cord-006229-7yoilsho	5694	9	study	study	NN
cord-006229-7yoilsho	5694	10	results	result	NNS
cord-006229-7yoilsho	5694	11	as	as	RB
cord-006229-7yoilsho	5694	12	well	well	RB
cord-006229-7yoilsho	5694	13	as	as	IN
cord-006229-7yoilsho	5694	14	cleaved	cleave	VBN
cord-006229-7yoilsho	5694	15	PARP	PARP	NNP
cord-006229-7yoilsho	5694	16	with	with	IN
cord-006229-7yoilsho	5694	17	Caspase	Caspase	NNP
cord-006229-7yoilsho	5694	18	3/7	3/7	CD
cord-006229-7yoilsho	5694	19	.	.	.
cord-006229-7yoilsho	5695	1	In	in	IN
cord-006229-7yoilsho	5695	2	addition	addition	NN
cord-006229-7yoilsho	5695	3	,	,	,
cord-006229-7yoilsho	5695	4	the	the	DT
cord-006229-7yoilsho	5695	5	TUNEL	TUNEL	NNP
cord-006229-7yoilsho	5695	6	assay	assay	NN
cord-006229-7yoilsho	5695	7	(	(	-LRB-
cord-006229-7yoilsho	5695	8	Click	click	VB
cord-006229-7yoilsho	5695	9	-	-	:
cord-006229-7yoilsho	5695	10	iT	it	PRP
cord-006229-7yoilsho	5696	1	®	®	.
cord-006229-7yoilsho	5697	1	TUNEL	TUNEL	NNP
cord-006229-7yoilsho	5697	2	Alexa	Alexa	NNP
cord-006229-7yoilsho	5697	3	Fluor	Fluor	NNP
cord-006229-7yoilsho	5697	4	,	,	,
cord-006229-7yoilsho	5697	5	Thermofisher	Thermofisher	NNP
cord-006229-7yoilsho	5697	6	)	)	-RRB-
cord-006229-7yoilsho	5697	7	was	be	VBD
cord-006229-7yoilsho	5697	8	executed	execute	VBN
cord-006229-7yoilsho	5697	9	to	to	IN
cord-006229-7yoilsho	5697	10	benchmark	benchmark	NN
cord-006229-7yoilsho	5697	11	cleaved	cleave	VBN
cord-006229-7yoilsho	5697	12	PARP	PARP	NNP
cord-006229-7yoilsho	5697	13	.	.	.
cord-006229-7yoilsho	5698	1	The	the	DT
cord-006229-7yoilsho	5698	2	benchmarking	benchmarking	NN
cord-006229-7yoilsho	5698	3	results	result	NNS
cord-006229-7yoilsho	5698	4	support	support	VBP
cord-006229-7yoilsho	5698	5	the	the	DT
cord-006229-7yoilsho	5698	6	selected	select	VBN
cord-006229-7yoilsho	5698	7	biomarkers	biomarker	NNS
cord-006229-7yoilsho	5698	8	of	of	IN
cord-006229-7yoilsho	5698	9	the	the	DT
cord-006229-7yoilsho	5698	10	multiplexed	multiplexed	JJ
cord-006229-7yoilsho	5698	11	assay	assay	NN
cord-006229-7yoilsho	5698	12	.	.	.
cord-006229-7yoilsho	5699	1	In	in	IN
cord-006229-7yoilsho	5699	2	stage	stage	NN
cord-006229-7yoilsho	5699	3	2	2	CD
cord-006229-7yoilsho	5699	4	,	,	,
cord-006229-7yoilsho	5699	5	additional	additional	JJ
cord-006229-7yoilsho	5699	6	reference	reference	NN
cord-006229-7yoilsho	5699	7	compounds	compound	NNS
cord-006229-7yoilsho	5699	8	(	(	-LRB-
cord-006229-7yoilsho	5699	9	three	three	CD
cord-006229-7yoilsho	5699	10	aneugens	aneugens	NNP
cord-006229-7yoilsho	5699	11	/	/	SYM
cord-006229-7yoilsho	5699	12	clastogens	clastogens	NNP
cord-006229-7yoilsho	5699	13	/	/	SYM
cord-006229-7yoilsho	5699	14	cytotoxicants	cytotoxicant	NNS
cord-006229-7yoilsho	5699	15	)	)	-RRB-
cord-006229-7yoilsho	5699	16	were	be	VBD
cord-006229-7yoilsho	5699	17	investigated	investigate	VBN
cord-006229-7yoilsho	5699	18	.	.	.
cord-006229-7yoilsho	5700	1	So	so	RB
cord-006229-7yoilsho	5700	2	far	far	RB
cord-006229-7yoilsho	5700	3	,	,	,
cord-006229-7yoilsho	5700	4	the	the	DT
cord-006229-7yoilsho	5700	5	chosen	choose	VBN
cord-006229-7yoilsho	5700	6	biomarkers	biomarker	NNS
cord-006229-7yoilsho	5700	7	of	of	IN
cord-006229-7yoilsho	5700	8	DNA	dna	NN
cord-006229-7yoilsho	5700	9	damage	damage	NN
cord-006229-7yoilsho	5700	10	response	response	NN
cord-006229-7yoilsho	5700	11	appear	appear	VBP
cord-006229-7yoilsho	5700	12	useful	useful	JJ
cord-006229-7yoilsho	5700	13	for	for	IN
cord-006229-7yoilsho	5700	14	class	class	NN
cord-006229-7yoilsho	5700	15	discrimination	discrimination	NN
cord-006229-7yoilsho	5700	16	and	and	CC
cord-006229-7yoilsho	5700	17	provide	provide	VB
cord-006229-7yoilsho	5700	18	additional	additional	JJ
cord-006229-7yoilsho	5700	19	information	information	NN
cord-006229-7yoilsho	5700	20	to	to	IN
cord-006229-7yoilsho	5700	21	existing	exist	VBG
cord-006229-7yoilsho	5700	22	genotoxicity	genotoxicity	NN
cord-006229-7yoilsho	5700	23	tests	test	NNS
cord-006229-7yoilsho	5700	24	.	.	.
cord-006229-7yoilsho	5701	1	Cell	cell	NN
cord-006229-7yoilsho	5701	2	-	-	HYPH
cord-006229-7yoilsho	5701	3	cell	cell	NN
cord-006229-7yoilsho	5701	4	contacts	contact	NNS
cord-006229-7yoilsho	5701	5	are	be	VBP
cord-006229-7yoilsho	5701	6	involved	involve	VBN
cord-006229-7yoilsho	5701	7	in	in	IN
cord-006229-7yoilsho	5701	8	keeping	keep	VBG
cord-006229-7yoilsho	5701	9	a	a	DT
cord-006229-7yoilsho	5701	10	physiological	physiological	JJ
cord-006229-7yoilsho	5701	11	balance	balance	NN
cord-006229-7yoilsho	5701	12	between	between	IN
cord-006229-7yoilsho	5701	13	proliferation	proliferation	NN
cord-006229-7yoilsho	5701	14	,	,	,
cord-006229-7yoilsho	5701	15	differentiation	differentiation	NN
cord-006229-7yoilsho	5701	16	and	and	CC
cord-006229-7yoilsho	5701	17	apoptosis	apoptosis	NN
cord-006229-7yoilsho	5701	18	.	.	.
cord-006229-7yoilsho	5702	1	Far	far	RB
cord-006229-7yoilsho	5702	2	less	less	JJR
cord-006229-7yoilsho	5702	3	is	be	VBZ
cord-006229-7yoilsho	5702	4	known	know	VBN
cord-006229-7yoilsho	5702	5	about	about	IN
cord-006229-7yoilsho	5702	6	the	the	DT
cord-006229-7yoilsho	5702	7	role	role	NN
cord-006229-7yoilsho	5702	8	of	of	IN
cord-006229-7yoilsho	5702	9	cell	cell	NN
cord-006229-7yoilsho	5702	10	-	-	HYPH
cord-006229-7yoilsho	5702	11	cell	cell	NN
cord-006229-7yoilsho	5702	12	-	-	HYPH
cord-006229-7yoilsho	5702	13	contacts	contact	NNS
cord-006229-7yoilsho	5702	14	in	in	IN
cord-006229-7yoilsho	5702	15	regulating	regulate	VBG
cord-006229-7yoilsho	5702	16	necrosis	necrosis	NN
cord-006229-7yoilsho	5702	17	,	,	,
cord-006229-7yoilsho	5702	18	for	for	IN
cord-006229-7yoilsho	5702	19	instance	instance	NN
cord-006229-7yoilsho	5702	20	in	in	IN
cord-006229-7yoilsho	5702	21	response	response	NN
cord-006229-7yoilsho	5702	22	to	to	IN
cord-006229-7yoilsho	5702	23	oxidative	oxidative	JJ
cord-006229-7yoilsho	5702	24	stress	stress	NN
cord-006229-7yoilsho	5702	25	.	.	.
cord-006229-7yoilsho	5703	1	Previous	previous	JJ
cord-006229-7yoilsho	5703	2	findings	finding	NNS
cord-006229-7yoilsho	5703	3	of	of	IN
cord-006229-7yoilsho	5703	4	our	-PRON-	PRP$
cord-006229-7yoilsho	5703	5	group	group	NN
cord-006229-7yoilsho	5703	6	demonstrated	demonstrate	VBD
cord-006229-7yoilsho	5703	7	that	that	IN
cord-006229-7yoilsho	5703	8	,	,	,
cord-006229-7yoilsho	5703	9	in	in	IN
cord-006229-7yoilsho	5703	10	contrast	contrast	NN
cord-006229-7yoilsho	5703	11	to	to	IN
cord-006229-7yoilsho	5703	12	semi	semi	JJ
cord-006229-7yoilsho	5703	13	-	-	JJ
cord-006229-7yoilsho	5703	14	confluent	confluent	JJ
cord-006229-7yoilsho	5703	15	proliferating	proliferate	VBG
cord-006229-7yoilsho	5703	16	cultures	culture	NNS
cord-006229-7yoilsho	5703	17	,	,	,
cord-006229-7yoilsho	5703	18	confluent	confluent	JJ
cord-006229-7yoilsho	5703	19	murine	murine	JJ
cord-006229-7yoilsho	5703	20	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	5703	21	(	(	-LRB-
cord-006229-7yoilsho	5703	22	NIH3T3	NIH3T3	NNP
cord-006229-7yoilsho	5703	23	,	,	,
cord-006229-7yoilsho	5703	24	MEF	MEF	NNP
cord-006229-7yoilsho	5703	25	)	)	-RRB-
cord-006229-7yoilsho	5703	26	and	and	CC
cord-006229-7yoilsho	5703	27	human	human	JJ
cord-006229-7yoilsho	5703	28	keratinocytes	keratinocyte	NNS
cord-006229-7yoilsho	5703	29	(	(	-LRB-
cord-006229-7yoilsho	5703	30	HaCaT	HaCaT	NNP
cord-006229-7yoilsho	5703	31	)	)	-RRB-
cord-006229-7yoilsho	5703	32	are	be	VBP
cord-006229-7yoilsho	5703	33	protected	protect	VBN
cord-006229-7yoilsho	5703	34	against	against	IN
cord-006229-7yoilsho	5703	35	necrosis	necrosis	NN
cord-006229-7yoilsho	5703	36	induced	induce	VBN
cord-006229-7yoilsho	5703	37	by	by	IN
cord-006229-7yoilsho	5703	38	tert	tert	NN
cord-006229-7yoilsho	5703	39	-	-	HYPH
cord-006229-7yoilsho	5703	40	butyl	butyl	NN
cord-006229-7yoilsho	5703	41	hydroperoxide	hydroperoxide	NN
cord-006229-7yoilsho	5703	42	(	(	-LRB-
cord-006229-7yoilsho	5703	43	t	t	NN
cord-006229-7yoilsho	5703	44	-	-	HYPH
cord-006229-7yoilsho	5703	45	BOOH	BOOH	NNP
cord-006229-7yoilsho	5703	46	)	)	-RRB-
cord-006229-7yoilsho	5703	47	.	.	.
cord-006229-7yoilsho	5704	1	Comparison	comparison	NN
cord-006229-7yoilsho	5704	2	of	of	IN
cord-006229-7yoilsho	5704	3	confluent	confluent	JJ
cord-006229-7yoilsho	5704	4	cells	cell	NNS
cord-006229-7yoilsho	5704	5	(	(	-LRB-
cord-006229-7yoilsho	5704	6	G0	g0	NN
cord-006229-7yoilsho	5704	7	/	/	SYM
cord-006229-7yoilsho	5704	8	G1	g1	NN
cord-006229-7yoilsho	5704	9	=	=	SYM
cord-006229-7yoilsho	5704	10	~70	~70	NFP
cord-006229-7yoilsho	5704	11	%	%	NN
cord-006229-7yoilsho	5704	12	)	)	-RRB-
cord-006229-7yoilsho	5704	13	and	and	CC
cord-006229-7yoilsho	5704	14	semi	semi	JJ
cord-006229-7yoilsho	5704	15	-	-	JJ
cord-006229-7yoilsho	5704	16	confluent	confluent	JJ
cord-006229-7yoilsho	5704	17	cultures	culture	NNS
cord-006229-7yoilsho	5704	18	,	,	,
cord-006229-7yoilsho	5704	19	similarly	similarly	RB
cord-006229-7yoilsho	5704	20	arrested	arrest	VBN
cord-006229-7yoilsho	5704	21	in	in	IN
cord-006229-7yoilsho	5704	22	the	the	DT
cord-006229-7yoilsho	5704	23	G0	G0	NNP
cord-006229-7yoilsho	5704	24	/	/	SYM
cord-006229-7yoilsho	5704	25	G1	G1	NNP
cord-006229-7yoilsho	5704	26	phase	phase	NN
cord-006229-7yoilsho	5704	27	by	by	IN
cord-006229-7yoilsho	5704	28	serum	serum	NN
cord-006229-7yoilsho	5704	29	-	-	HYPH
cord-006229-7yoilsho	5704	30	starvation	starvation	NN
cord-006229-7yoilsho	5704	31	or	or	CC
cord-006229-7yoilsho	5704	32	the	the	DT
cord-006229-7yoilsho	5704	33	MEK	MEK	NNP
cord-006229-7yoilsho	5704	34	inhibitor	inhibitor	NN
cord-006229-7yoilsho	5704	35	U0126	U0126	NNP
cord-006229-7yoilsho	5704	36	,	,	,
cord-006229-7yoilsho	5704	37	ascertained	ascertain	VBD
cord-006229-7yoilsho	5704	38	that	that	IN
cord-006229-7yoilsho	5704	39	the	the	DT
cord-006229-7yoilsho	5704	40	resistance	resistance	NN
cord-006229-7yoilsho	5704	41	against	against	IN
cord-006229-7yoilsho	5704	42	t	t	NN
cord-006229-7yoilsho	5704	43	-	-	HYPH
cord-006229-7yoilsho	5704	44	BOOH	BOOH	NNP
cord-006229-7yoilsho	5704	45	is	be	VBZ
cord-006229-7yoilsho	5704	46	mediated	mediate	VBN
cord-006229-7yoilsho	5704	47	by	by	IN
cord-006229-7yoilsho	5704	48	cell	cell	NN
cord-006229-7yoilsho	5704	49	-	-	HYPH
cord-006229-7yoilsho	5704	50	cell	cell	NN
cord-006229-7yoilsho	5704	51	contacts	contact	NNS
cord-006229-7yoilsho	5704	52	and	and	CC
cord-006229-7yoilsho	5704	53	not	not	RB
cord-006229-7yoilsho	5704	54	by	by	IN
cord-006229-7yoilsho	5704	55	cell	cell	NN
cord-006229-7yoilsho	5704	56	cycle	cycle	NN
cord-006229-7yoilsho	5704	57	arrest	arrest	NN
cord-006229-7yoilsho	5704	58	.	.	.
cord-006229-7yoilsho	5705	1	We	-PRON-	PRP
cord-006229-7yoilsho	5705	2	further	further	RB
cord-006229-7yoilsho	5705	3	revealed	reveal	VBD
cord-006229-7yoilsho	5705	4	that	that	IN
cord-006229-7yoilsho	5705	5	confluent	confluent	JJ
cord-006229-7yoilsho	5705	6	cultures	culture	NNS
cord-006229-7yoilsho	5705	7	are	be	VBP
cord-006229-7yoilsho	5705	8	protected	protect	VBN
cord-006229-7yoilsho	5705	9	against	against	IN
cord-006229-7yoilsho	5705	10	t	t	NN
cord-006229-7yoilsho	5705	11	-	-	HYPH
cord-006229-7yoilsho	5705	12	BOOH	BOOH	NNP
cord-006229-7yoilsho	5705	13	-	-	HYPH
cord-006229-7yoilsho	5705	14	induced	induce	VBN
cord-006229-7yoilsho	5705	15	DNA	dna	NN
cord-006229-7yoilsho	5705	16	double	double	JJ
cord-006229-7yoilsho	5705	17	strand	strand	NN
cord-006229-7yoilsho	5705	18	breaks	break	NNS
cord-006229-7yoilsho	5705	19	as	as	IN
cord-006229-7yoilsho	5705	20	assessed	assess	VBN
cord-006229-7yoilsho	5705	21	by	by	IN
cord-006229-7yoilsho	5705	22	the	the	DT
cord-006229-7yoilsho	5705	23	neutral	neutral	JJ
cord-006229-7yoilsho	5705	24	comet	comet	JJ
cord-006229-7yoilsho	5705	25	assay	assay	NN
cord-006229-7yoilsho	5705	26	and	and	CC
cord-006229-7yoilsho	5705	27	against	against	IN
cord-006229-7yoilsho	5705	28	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	5705	29	damage	damage	NN
cord-006229-7yoilsho	5705	30	detected	detect	VBN
cord-006229-7yoilsho	5705	31	by	by	IN
cord-006229-7yoilsho	5705	32	flow	flow	NN
cord-006229-7yoilsho	5705	33	cytometric	cytometric	NN
cord-006229-7yoilsho	5705	34	analysis	analysis	NN
cord-006229-7yoilsho	5705	35	of	of	IN
cord-006229-7yoilsho	5705	36	DiOC6	DiOC6	NNP
cord-006229-7yoilsho	5705	37	staining	stain	VBG
cord-006229-7yoilsho	5705	38	.	.	.
cord-006229-7yoilsho	5706	1	To	to	TO
cord-006229-7yoilsho	5706	2	better	well	RBR
cord-006229-7yoilsho	5706	3	understand	understand	VB
cord-006229-7yoilsho	5706	4	the	the	DT
cord-006229-7yoilsho	5706	5	protective	protective	JJ
cord-006229-7yoilsho	5706	6	role	role	NN
cord-006229-7yoilsho	5706	7	of	of	IN
cord-006229-7yoilsho	5706	8	cell	cell	NN
cord-006229-7yoilsho	5706	9	-	-	HYPH
cord-006229-7yoilsho	5706	10	cell	cell	NN
cord-006229-7yoilsho	5706	11	-	-	HYPH
cord-006229-7yoilsho	5706	12	contacts	contact	NNS
cord-006229-7yoilsho	5706	13	in	in	IN
cord-006229-7yoilsho	5706	14	ROS	ROS	NNP
cord-006229-7yoilsho	5706	15	-	-	HYPH
cord-006229-7yoilsho	5706	16	mediated	mediate	VBN
cord-006229-7yoilsho	5706	17	necrosis	necrosis	NN
cord-006229-7yoilsho	5706	18	,	,	,
cord-006229-7yoilsho	5706	19	we	-PRON-	PRP
cord-006229-7yoilsho	5706	20	started	start	VBD
cord-006229-7yoilsho	5706	21	characterizing	characterize	VBG
cord-006229-7yoilsho	5706	22	the	the	DT
cord-006229-7yoilsho	5706	23	signaling	signal	VBG
cord-006229-7yoilsho	5706	24	cascade	cascade	NN
cord-006229-7yoilsho	5706	25	induced	induce	VBN
cord-006229-7yoilsho	5706	26	by	by	IN
cord-006229-7yoilsho	5706	27	t	t	NN
cord-006229-7yoilsho	5706	28	-	-	HYPH
cord-006229-7yoilsho	5706	29	BOOH	BOOH	NNP
cord-006229-7yoilsho	5706	30	in	in	IN
cord-006229-7yoilsho	5706	31	semi	semi	JJ
cord-006229-7yoilsho	5706	32	-	-	JJ
cord-006229-7yoilsho	5706	33	confluent	confluent	JJ
cord-006229-7yoilsho	5706	34	proliferating	proliferate	VBG
cord-006229-7yoilsho	5706	35	cultures	culture	NNS
cord-006229-7yoilsho	5706	36	.	.	.
cord-006229-7yoilsho	5707	1	In	in	IN
cord-006229-7yoilsho	5707	2	accordance	accordance	NN
cord-006229-7yoilsho	5707	3	with	with	IN
cord-006229-7yoilsho	5707	4	the	the	DT
cord-006229-7yoilsho	5707	5	observed	observed	JJ
cord-006229-7yoilsho	5707	6	formation	formation	NN
cord-006229-7yoilsho	5707	7	of	of	IN
cord-006229-7yoilsho	5707	8	DNA	dna	NN
cord-006229-7yoilsho	5707	9	double	double	JJ
cord-006229-7yoilsho	5707	10	strand	strand	NN
cord-006229-7yoilsho	5707	11	breaks	break	NNS
cord-006229-7yoilsho	5707	12	in	in	IN
cord-006229-7yoilsho	5707	13	response	response	NN
cord-006229-7yoilsho	5707	14	to	to	IN
cord-006229-7yoilsho	5707	15	t	t	NN
cord-006229-7yoilsho	5707	16	-	-	HYPH
cord-006229-7yoilsho	5707	17	BOOH	BOOH	NNP
cord-006229-7yoilsho	5707	18	,	,	,
cord-006229-7yoilsho	5707	19	we	-PRON-	PRP
cord-006229-7yoilsho	5707	20	detected	detect	VBD
cord-006229-7yoilsho	5707	21	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	5707	22	of	of	IN
cord-006229-7yoilsho	5707	23	the	the	DT
cord-006229-7yoilsho	5707	24	checkpoint	checkpoint	NN
cord-006229-7yoilsho	5707	25	kinase	kinase	NN
cord-006229-7yoilsho	5707	26	Chk2	Chk2	NNP
cord-006229-7yoilsho	5707	27	.	.	.
cord-006229-7yoilsho	5708	1	However	however	RB
cord-006229-7yoilsho	5708	2	,	,	,
cord-006229-7yoilsho	5708	3	inhibition	inhibition	NN
cord-006229-7yoilsho	5708	4	of	of	IN
cord-006229-7yoilsho	5708	5	ATM	atm	NN
cord-006229-7yoilsho	5708	6	,	,	,
cord-006229-7yoilsho	5708	7	the	the	DT
cord-006229-7yoilsho	5708	8	kinase	kinase	NN
cord-006229-7yoilsho	5708	9	responsible	responsible	JJ
cord-006229-7yoilsho	5708	10	for	for	IN
cord-006229-7yoilsho	5708	11	Chk2	Chk2	NNP
cord-006229-7yoilsho	5708	12	activation	activation	NN
cord-006229-7yoilsho	5708	13	,	,	,
cord-006229-7yoilsho	5708	14	did	do	VBD
cord-006229-7yoilsho	5708	15	not	not	RB
cord-006229-7yoilsho	5708	16	influence	influence	VB
cord-006229-7yoilsho	5708	17	t	t	NN
cord-006229-7yoilsho	5708	18	-	-	HYPH
cord-006229-7yoilsho	5708	19	BOOH	BOOH	NNP
cord-006229-7yoilsho	5708	20	-	-	HYPH
cord-006229-7yoilsho	5708	21	induced	induce	VBN
cord-006229-7yoilsho	5708	22	cell	cell	NN
cord-006229-7yoilsho	5708	23	death	death	NN
cord-006229-7yoilsho	5708	24	.	.	.
cord-006229-7yoilsho	5709	1	Interestingly	interestingly	RB
cord-006229-7yoilsho	5709	2	,	,	,
cord-006229-7yoilsho	5709	3	first	first	JJ
cord-006229-7yoilsho	5709	4	experiments	experiment	NNS
cord-006229-7yoilsho	5709	5	gave	give	VBD
cord-006229-7yoilsho	5709	6	a	a	DT
cord-006229-7yoilsho	5709	7	hint	hint	NN
cord-006229-7yoilsho	5709	8	for	for	IN
cord-006229-7yoilsho	5709	9	the	the	DT
cord-006229-7yoilsho	5709	10	participation	participation	NN
cord-006229-7yoilsho	5709	11	of	of	IN
cord-006229-7yoilsho	5709	12	RIP1	RIP1	NNP
cord-006229-7yoilsho	5709	13	,	,	,
cord-006229-7yoilsho	5709	14	since	since	IN
cord-006229-7yoilsho	5709	15	the	the	DT
cord-006229-7yoilsho	5709	16	chemical	chemical	JJ
cord-006229-7yoilsho	5709	17	RIP1	RIP1	NNP
cord-006229-7yoilsho	5709	18	kinase	kinase	NN
cord-006229-7yoilsho	5709	19	inhibitor	inhibitor	NN
cord-006229-7yoilsho	5709	20	Necrostatin-1	Necrostatin-1	NNP
cord-006229-7yoilsho	5709	21	(	(	-LRB-
cord-006229-7yoilsho	5709	22	Nec-1	Nec-1	NNP
cord-006229-7yoilsho	5709	23	)	)	-RRB-
cord-006229-7yoilsho	5709	24	blocked	block	VBD
cord-006229-7yoilsho	5709	25	cell	cell	NN
cord-006229-7yoilsho	5709	26	death	death	NN
cord-006229-7yoilsho	5709	27	up	up	IN
cord-006229-7yoilsho	5709	28	to	to	IN
cord-006229-7yoilsho	5709	29	averagely	averagely	RB
cord-006229-7yoilsho	5709	30	50	50	CD
cord-006229-7yoilsho	5709	31	%	%	NN
cord-006229-7yoilsho	5709	32	,	,	,
cord-006229-7yoilsho	5709	33	what	what	WP
cord-006229-7yoilsho	5709	34	is	be	VBZ
cord-006229-7yoilsho	5709	35	described	describe	VBN
cord-006229-7yoilsho	5709	36	as	as	IN
cord-006229-7yoilsho	5709	37	a	a	DT
cord-006229-7yoilsho	5709	38	specific	specific	JJ
cord-006229-7yoilsho	5709	39	marker	marker	NN
cord-006229-7yoilsho	5709	40	for	for	IN
cord-006229-7yoilsho	5709	41	regulated	regulated	JJ
cord-006229-7yoilsho	5709	42	necrosis	necrosis	NN
cord-006229-7yoilsho	5709	43	.	.	.
cord-006229-7yoilsho	5710	1	In	in	IN
cord-006229-7yoilsho	5710	2	line	line	NN
cord-006229-7yoilsho	5710	3	with	with	IN
cord-006229-7yoilsho	5710	4	this	this	DT
cord-006229-7yoilsho	5710	5	observation	observation	NN
cord-006229-7yoilsho	5710	6	,	,	,
cord-006229-7yoilsho	5710	7	t	t	NN
cord-006229-7yoilsho	5710	8	-	-	HYPH
cord-006229-7yoilsho	5710	9	BOOH	BOOH	NNP
cord-006229-7yoilsho	5710	10	-	-	HYPH
cord-006229-7yoilsho	5710	11	induced	induce	VBN
cord-006229-7yoilsho	5710	12	cell	cell	NN
cord-006229-7yoilsho	5710	13	death	death	NN
cord-006229-7yoilsho	5710	14	could	could	MD
cord-006229-7yoilsho	5710	15	not	not	RB
cord-006229-7yoilsho	5710	16	be	be	VB
cord-006229-7yoilsho	5710	17	blocked	block	VBN
cord-006229-7yoilsho	5710	18	by	by	IN
cord-006229-7yoilsho	5711	1	the	the	DT
cord-006229-7yoilsho	5711	2	pan	pan	JJ
cord-006229-7yoilsho	5711	3	-	-	JJ
cord-006229-7yoilsho	5711	4	caspase	caspase	JJ
cord-006229-7yoilsho	5711	5	inhibitor	inhibitor	NN
cord-006229-7yoilsho	5711	6	z	z	NNP
cord-006229-7yoilsho	5711	7	-	-	HYPH
cord-006229-7yoilsho	5711	8	VAD	VAD	NNP
cord-006229-7yoilsho	5711	9	-	-	HYPH
cord-006229-7yoilsho	5711	10	FMK	FMK	NNP
cord-006229-7yoilsho	5711	11	strongly	strongly	RB
cord-006229-7yoilsho	5711	12	indicating	indicate	VBG
cord-006229-7yoilsho	5711	13	that	that	IN
cord-006229-7yoilsho	5711	14	caspase	caspase	NN
cord-006229-7yoilsho	5711	15	activity	activity	NN
cord-006229-7yoilsho	5711	16	is	be	VBZ
cord-006229-7yoilsho	5711	17	not	not	RB
cord-006229-7yoilsho	5711	18	required	require	VBN
cord-006229-7yoilsho	5711	19	.	.	.
cord-006229-7yoilsho	5712	1	Moreover	moreover	RB
cord-006229-7yoilsho	5712	2	,	,	,
cord-006229-7yoilsho	5712	3	PARP-1	PARP-1	NNS
cord-006229-7yoilsho	5712	4	and	and	CC
cord-006229-7yoilsho	5712	5	p53	p53	NN
cord-006229-7yoilsho	5712	6	are	be	VBP
cord-006229-7yoilsho	5712	7	probably	probably	RB
cord-006229-7yoilsho	5712	8	not	not	RB
cord-006229-7yoilsho	5712	9	involved	involve	VBN
cord-006229-7yoilsho	5712	10	.	.	.
cord-006229-7yoilsho	5713	1	Deeper	deep	JJR
cord-006229-7yoilsho	5713	2	analyses	analysis	NNS
cord-006229-7yoilsho	5713	3	could	could	MD
cord-006229-7yoilsho	5713	4	give	give	VB
cord-006229-7yoilsho	5713	5	evidence	evidence	NN
cord-006229-7yoilsho	5713	6	that	that	IN
cord-006229-7yoilsho	5713	7	Nec-1	Nec-1	NNP
cord-006229-7yoilsho	5713	8	did	do	VBD
cord-006229-7yoilsho	5713	9	not	not	RB
cord-006229-7yoilsho	5713	10	block	block	VB
cord-006229-7yoilsho	5713	11	formation	formation	NN
cord-006229-7yoilsho	5713	12	of	of	IN
cord-006229-7yoilsho	5713	13	DNA	dna	NN
cord-006229-7yoilsho	5713	14	double	double	JJ
cord-006229-7yoilsho	5713	15	strand	strand	NN
cord-006229-7yoilsho	5713	16	breaks	break	NNS
cord-006229-7yoilsho	5713	17	nor	nor	CC
cord-006229-7yoilsho	5713	18	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	5713	19	damage	damage	NN
cord-006229-7yoilsho	5713	20	indicating	indicate	VBG
cord-006229-7yoilsho	5713	21	that	that	IN
cord-006229-7yoilsho	5713	22	the	the	DT
cord-006229-7yoilsho	5713	23	kinase	kinase	NN
cord-006229-7yoilsho	5713	24	blocked	block	VBN
cord-006229-7yoilsho	5713	25	by	by	IN
cord-006229-7yoilsho	5713	26	Nec-1	Nec-1	NNP
cord-006229-7yoilsho	5713	27	,	,	,
cord-006229-7yoilsho	5713	28	possibly	possibly	RB
cord-006229-7yoilsho	5713	29	RIP1	RIP1	NNP
cord-006229-7yoilsho	5713	30	,	,	,
cord-006229-7yoilsho	5713	31	acts	act	VBZ
cord-006229-7yoilsho	5713	32	downstream	downstream	RB
cord-006229-7yoilsho	5713	33	of	of	IN
cord-006229-7yoilsho	5713	34	DNA	dna	NN
cord-006229-7yoilsho	5713	35	double	double	JJ
cord-006229-7yoilsho	5713	36	strand	strand	NN
cord-006229-7yoilsho	5713	37	breaks	break	NNS
cord-006229-7yoilsho	5713	38	and	and	CC
cord-006229-7yoilsho	5713	39	/	/	SYM
cord-006229-7yoilsho	5713	40	or	or	CC
cord-006229-7yoilsho	5713	41	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	5713	42	damage	damage	NN
cord-006229-7yoilsho	5713	43	.	.	.
cord-006229-7yoilsho	5714	1	In	in	IN
cord-006229-7yoilsho	5714	2	the	the	DT
cord-006229-7yoilsho	5714	3	end	end	NN
cord-006229-7yoilsho	5714	4	,	,	,
cord-006229-7yoilsho	5714	5	we	-PRON-	PRP
cord-006229-7yoilsho	5714	6	could	could	MD
cord-006229-7yoilsho	5714	7	identify	identify	VB
cord-006229-7yoilsho	5714	8	a	a	DT
cord-006229-7yoilsho	5714	9	crucial	crucial	JJ
cord-006229-7yoilsho	5714	10	role	role	NN
cord-006229-7yoilsho	5714	11	of	of	IN
cord-006229-7yoilsho	5714	12	Ca	Ca	NNP
cord-006229-7yoilsho	5714	13	2	2	CD
cord-006229-7yoilsho	5714	14	+	+	CC
cord-006229-7yoilsho	5714	15	signaling	signal	VBG
cord-006229-7yoilsho	5714	16	for	for	IN
cord-006229-7yoilsho	5714	17	t	t	NN
cord-006229-7yoilsho	5714	18	-	-	HYPH
cord-006229-7yoilsho	5714	19	BOOH	BOOH	NNP
cord-006229-7yoilsho	5714	20	-	-	HYPH
cord-006229-7yoilsho	5714	21	mediated	mediate	VBN
cord-006229-7yoilsho	5714	22	toxicity	toxicity	NN
cord-006229-7yoilsho	5714	23	.	.	.
cord-006229-7yoilsho	5715	1	As	as	IN
cord-006229-7yoilsho	5715	2	the	the	DT
cord-006229-7yoilsho	5715	3	calcium	calcium	NN
cord-006229-7yoilsho	5715	4	chelator	chelator	NN
cord-006229-7yoilsho	5715	5	BAPTA	BAPTA	NNP
cord-006229-7yoilsho	5715	6	-	-	HYPH
cord-006229-7yoilsho	5715	7	AM	AM	NNP
cord-006229-7yoilsho	5715	8	was	be	VBD
cord-006229-7yoilsho	5715	9	able	able	JJ
cord-006229-7yoilsho	5715	10	to	to	TO
cord-006229-7yoilsho	5715	11	completely	completely	RB
cord-006229-7yoilsho	5715	12	block	block	VB
cord-006229-7yoilsho	5715	13	not	not	RB
cord-006229-7yoilsho	5715	14	only	only	JJ
cord-006229-7yoilsho	5715	15	cell	cell	NN
cord-006229-7yoilsho	5715	16	death	death	NN
cord-006229-7yoilsho	5715	17	,	,	,
cord-006229-7yoilsho	5715	18	but	but	CC
cord-006229-7yoilsho	5715	19	also	also	RB
cord-006229-7yoilsho	5715	20	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	5715	21	damage	damage	NN
cord-006229-7yoilsho	5715	22	and	and	CC
cord-006229-7yoilsho	5715	23	DNA	dna	NN
cord-006229-7yoilsho	5715	24	double	double	JJ
cord-006229-7yoilsho	5715	25	-	-	HYPH
cord-006229-7yoilsho	5715	26	strand	strand	NN
cord-006229-7yoilsho	5715	27	break	break	NN
cord-006229-7yoilsho	5715	28	formation	formation	NN
cord-006229-7yoilsho	5715	29	,	,	,
cord-006229-7yoilsho	5715	30	there	there	EX
cord-006229-7yoilsho	5715	31	is	be	VBZ
cord-006229-7yoilsho	5715	32	a	a	DT
cord-006229-7yoilsho	5715	33	strong	strong	JJ
cord-006229-7yoilsho	5715	34	need	need	NN
cord-006229-7yoilsho	5715	35	for	for	IN
cord-006229-7yoilsho	5715	36	further	further	JJ
cord-006229-7yoilsho	5715	37	investigations	investigation	NNS
cord-006229-7yoilsho	5715	38	of	of	IN
cord-006229-7yoilsho	5715	39	the	the	DT
cord-006229-7yoilsho	5715	40	possible	possible	JJ
cord-006229-7yoilsho	5715	41	interplay	interplay	NN
cord-006229-7yoilsho	5715	42	between	between	IN
cord-006229-7yoilsho	5715	43	regulated	regulated	JJ
cord-006229-7yoilsho	5715	44	necrosis	necrosis	NN
cord-006229-7yoilsho	5715	45	and	and	CC
cord-006229-7yoilsho	5715	46	calcium	calcium	NN
cord-006229-7yoilsho	5715	47	,	,	,
cord-006229-7yoilsho	5715	48	regulated	regulate	VBN
cord-006229-7yoilsho	5715	49	by	by	IN
cord-006229-7yoilsho	5715	50	cell	cell	NN
cord-006229-7yoilsho	5715	51	-	-	HYPH
cord-006229-7yoilsho	5715	52	cell	cell	NN
cord-006229-7yoilsho	5715	53	contacts	contact	NNS
cord-006229-7yoilsho	5715	54	among	among	IN
cord-006229-7yoilsho	5715	55	oxidative	oxidative	JJ
cord-006229-7yoilsho	5715	56	stress	stress	NN
cord-006229-7yoilsho	5715	57	.	.	.
cord-006229-7yoilsho	5716	1	The	the	DT
cord-006229-7yoilsho	5716	2	work	work	NN
cord-006229-7yoilsho	5716	3	was	be	VBD
cord-006229-7yoilsho	5716	4	supported	support	VBN
cord-006229-7yoilsho	5716	5	by	by	IN
cord-006229-7yoilsho	5716	6	the	the	DT
cord-006229-7yoilsho	5716	7	Hoffmann	Hoffmann	NNP
cord-006229-7yoilsho	5716	8	-	-	HYPH
cord-006229-7yoilsho	5716	9	Klose	Klose	NNP
cord-006229-7yoilsho	5716	10	-	-	HYPH
cord-006229-7yoilsho	5716	11	Stiftung	Stiftung	NNP
cord-006229-7yoilsho	5716	12	,	,	,
cord-006229-7yoilsho	5716	13	the	the	DT
cord-006229-7yoilsho	5716	14	Promotionsförderung	Promotionsförderung	NNP
cord-006229-7yoilsho	5716	15	Rheinland	Rheinland	NNP
cord-006229-7yoilsho	5716	16	-	-	HYPH
cord-006229-7yoilsho	5716	17	Pfalz	Pfalz	NNP
cord-006229-7yoilsho	5716	18	,	,	,
cord-006229-7yoilsho	5716	19	the	the	DT
cord-006229-7yoilsho	5716	20	Johannes	Johannes	NNP
cord-006229-7yoilsho	5716	21	Gutenberg	Gutenberg	NNP
cord-006229-7yoilsho	5716	22	-	-	HYPH
cord-006229-7yoilsho	5716	23	University	University	NNP
cord-006229-7yoilsho	5716	24	and	and	CC
cord-006229-7yoilsho	5716	25	the	the	DT
cord-006229-7yoilsho	5716	26	University	University	NNP
cord-006229-7yoilsho	5716	27	Medical	Medical	NNP
cord-006229-7yoilsho	5716	28	Center	Center	NNP
cord-006229-7yoilsho	5716	29	of	of	IN
cord-006229-7yoilsho	5716	30	the	the	DT
cord-006229-7yoilsho	5716	31	Johannes	Johannes	NNP
cord-006229-7yoilsho	5716	32	Gutenberg	Gutenberg	NNP
cord-006229-7yoilsho	5716	33	-	-	HYPH
cord-006229-7yoilsho	5716	34	University	University	NNP
cord-006229-7yoilsho	5716	35	.	.	.
cord-006229-7yoilsho	5717	1	The	the	DT
cord-006229-7yoilsho	5717	2	mammalian	mammalian	JJ
cord-006229-7yoilsho	5717	3	target	target	NN
cord-006229-7yoilsho	5717	4	of	of	IN
cord-006229-7yoilsho	5717	5	rapamycin	rapamycin	NNP
cord-006229-7yoilsho	5717	6	(	(	-LRB-
cord-006229-7yoilsho	5717	7	mTOR	mTOR	NNP
cord-006229-7yoilsho	5717	8	)	)	-RRB-
cord-006229-7yoilsho	5717	9	forms	form	VBZ
cord-006229-7yoilsho	5717	10	two	two	CD
cord-006229-7yoilsho	5717	11	multiprotein	multiprotein	NNP
cord-006229-7yoilsho	5717	12	complexes	complex	NNS
cord-006229-7yoilsho	5717	13	(	(	-LRB-
cord-006229-7yoilsho	5717	14	mTORC1	mTORC1	NNP
cord-006229-7yoilsho	5717	15	and	and	CC
cord-006229-7yoilsho	5717	16	mTORC2	mTORC2	NNPS
cord-006229-7yoilsho	5717	17	)	)	-RRB-
cord-006229-7yoilsho	5717	18	and	and	CC
cord-006229-7yoilsho	5717	19	influences	influence	VBZ
cord-006229-7yoilsho	5717	20	cell	cell	NN
cord-006229-7yoilsho	5717	21	growth	growth	NN
cord-006229-7yoilsho	5717	22	,	,	,
cord-006229-7yoilsho	5717	23	proliferation	proliferation	NN
cord-006229-7yoilsho	5717	24	,	,	,
cord-006229-7yoilsho	5717	25	survival	survival	NN
cord-006229-7yoilsho	5717	26	and	and	CC
cord-006229-7yoilsho	5717	27	metabolism	metabolism	NN
cord-006229-7yoilsho	5717	28	.	.	.
cord-006229-7yoilsho	5718	1	Constitutively	Constitutively	NNP
cord-006229-7yoilsho	5718	2	activated	activate	VBD
cord-006229-7yoilsho	5718	3	mTOR	mTOR	NNP
cord-006229-7yoilsho	5718	4	was	be	VBD
cord-006229-7yoilsho	5718	5	found	find	VBN
cord-006229-7yoilsho	5718	6	to	to	TO
cord-006229-7yoilsho	5718	7	be	be	VB
cord-006229-7yoilsho	5718	8	deregulated	deregulate	VBN
cord-006229-7yoilsho	5718	9	in	in	IN
cord-006229-7yoilsho	5718	10	several	several	JJ
cord-006229-7yoilsho	5718	11	cancer	cancer	NN
cord-006229-7yoilsho	5718	12	types	type	NNS
cord-006229-7yoilsho	5718	13	,	,	,
cord-006229-7yoilsho	5718	14	which	which	WDT
cord-006229-7yoilsho	5718	15	makes	make	VBZ
cord-006229-7yoilsho	5718	16	it	-PRON-	PRP
cord-006229-7yoilsho	5718	17	an	an	DT
cord-006229-7yoilsho	5718	18	interesting	interesting	JJ
cord-006229-7yoilsho	5718	19	target	target	NN
cord-006229-7yoilsho	5718	20	for	for	IN
cord-006229-7yoilsho	5718	21	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	5718	22	cancer	cancer	NN
cord-006229-7yoilsho	5718	23	strategies	strategy	NNS
cord-006229-7yoilsho	5718	24	.	.	.
cord-006229-7yoilsho	5719	1	Rapamycin	Rapamycin	NNP
cord-006229-7yoilsho	5719	2	is	be	VBZ
cord-006229-7yoilsho	5719	3	able	able	JJ
cord-006229-7yoilsho	5719	4	to	to	TO
cord-006229-7yoilsho	5719	5	inhibit	inhibit	VB
cord-006229-7yoilsho	5719	6	mTOR	mTOR	NNP
cord-006229-7yoilsho	5719	7	and	and	CC
cord-006229-7yoilsho	5719	8	its	-PRON-	PRP$
cord-006229-7yoilsho	5719	9	downstream	downstream	JJ
cord-006229-7yoilsho	5719	10	targets	target	NNS
cord-006229-7yoilsho	5719	11	and	and	CC
cord-006229-7yoilsho	5719	12	is	be	VBZ
cord-006229-7yoilsho	5719	13	currently	currently	RB
cord-006229-7yoilsho	5719	14	studied	study	VBN
cord-006229-7yoilsho	5719	15	for	for	IN
cord-006229-7yoilsho	5719	16	its	-PRON-	PRP$
cord-006229-7yoilsho	5719	17	anticancer	anticancer	JJ
cord-006229-7yoilsho	5719	18	properties	property	NNS
cord-006229-7yoilsho	5719	19	in	in	IN
cord-006229-7yoilsho	5719	20	clinical	clinical	JJ
cord-006229-7yoilsho	5719	21	trials	trial	NNS
cord-006229-7yoilsho	5719	22	.	.	.
cord-006229-7yoilsho	5720	1	Despite	despite	IN
cord-006229-7yoilsho	5720	2	previous	previous	JJ
cord-006229-7yoilsho	5720	3	evidence	evidence	NN
cord-006229-7yoilsho	5720	4	,	,	,
cord-006229-7yoilsho	5720	5	there	there	EX
cord-006229-7yoilsho	5720	6	are	be	VBP
cord-006229-7yoilsho	5720	7	studies	study	NNS
cord-006229-7yoilsho	5720	8	that	that	WDT
cord-006229-7yoilsho	5720	9	show	show	VBP
cord-006229-7yoilsho	5720	10	an	an	DT
cord-006229-7yoilsho	5720	11	adverse	adverse	JJ
cord-006229-7yoilsho	5720	12	effect	effect	NN
cord-006229-7yoilsho	5720	13	in	in	IN
cord-006229-7yoilsho	5720	14	cancer	cancer	NN
cord-006229-7yoilsho	5720	15	treatment	treatment	NN
cord-006229-7yoilsho	5720	16	causing	cause	VBG
cord-006229-7yoilsho	5720	17	tumour	tumour	NN
cord-006229-7yoilsho	5720	18	growth	growth	NN
cord-006229-7yoilsho	5720	19	,	,	,
cord-006229-7yoilsho	5720	20	evolving	evolve	VBG
cord-006229-7yoilsho	5720	21	the	the	DT
cord-006229-7yoilsho	5720	22	question	question	NN
cord-006229-7yoilsho	5720	23	of	of	IN
cord-006229-7yoilsho	5720	24	the	the	DT
cord-006229-7yoilsho	5720	25	effectiveness	effectiveness	NN
cord-006229-7yoilsho	5720	26	of	of	IN
cord-006229-7yoilsho	5720	27	the	the	DT
cord-006229-7yoilsho	5720	28	drug	drug	NN
cord-006229-7yoilsho	5720	29	in	in	IN
cord-006229-7yoilsho	5720	30	cancer	cancer	NN
cord-006229-7yoilsho	5720	31	treatment	treatment	NN
cord-006229-7yoilsho	5720	32	.	.	.
cord-006229-7yoilsho	5721	1	Therefore	therefore	RB
cord-006229-7yoilsho	5721	2	,	,	,
cord-006229-7yoilsho	5721	3	we	-PRON-	PRP
cord-006229-7yoilsho	5721	4	examined	examine	VBD
cord-006229-7yoilsho	5721	5	the	the	DT
cord-006229-7yoilsho	5721	6	transformational	transformational	JJ
cord-006229-7yoilsho	5721	7	potential	potential	NN
cord-006229-7yoilsho	5721	8	of	of	IN
cord-006229-7yoilsho	5721	9	rapamycin	rapamycin	NNS
cord-006229-7yoilsho	5721	10	in	in	IN
cord-006229-7yoilsho	5721	11	a	a	DT
cord-006229-7yoilsho	5721	12	BALB	BALB	NNP
cord-006229-7yoilsho	5721	13	/	/	SYM
cord-006229-7yoilsho	5721	14	c	c	NN
cord-006229-7yoilsho	5721	15	cell	cell	NN
cord-006229-7yoilsho	5721	16	transformation	transformation	NN
cord-006229-7yoilsho	5721	17	assay	assay	NN
cord-006229-7yoilsho	5721	18	(	(	-LRB-
cord-006229-7yoilsho	5721	19	CTA	CTA	NNP
cord-006229-7yoilsho	5721	20	)	)	-RRB-
cord-006229-7yoilsho	5721	21	as	as	RB
cord-006229-7yoilsho	5721	22	well	well	RB
cord-006229-7yoilsho	5721	23	as	as	IN
cord-006229-7yoilsho	5721	24	markers	marker	NNS
cord-006229-7yoilsho	5721	25	of	of	IN
cord-006229-7yoilsho	5721	26	proliferation	proliferation	NN
cord-006229-7yoilsho	5721	27	and	and	CC
cord-006229-7yoilsho	5721	28	protein	protein	NN
cord-006229-7yoilsho	5721	29	synthesis	synthesis	NN
cord-006229-7yoilsho	5721	30	.	.	.
cord-006229-7yoilsho	5722	1	The	the	DT
cord-006229-7yoilsho	5722	2	BALB	BALB	NNP
cord-006229-7yoilsho	5722	3	/	/	SYM
cord-006229-7yoilsho	5722	4	c	c	NN
cord-006229-7yoilsho	5722	5	3T3	3t3	CD
cord-006229-7yoilsho	5722	6	cell	cell	NN
cord-006229-7yoilsho	5722	7	transformation	transformation	NN
cord-006229-7yoilsho	5722	8	assay	assay	NN
cord-006229-7yoilsho	5722	9	mimics	mimic	VBZ
cord-006229-7yoilsho	5722	10	different	different	JJ
cord-006229-7yoilsho	5722	11	stages	stage	NNS
cord-006229-7yoilsho	5722	12	of	of	IN
cord-006229-7yoilsho	5722	13	in	in	IN
cord-006229-7yoilsho	5722	14	vivo	vivo	NN
cord-006229-7yoilsho	5722	15	carcinogenicity	carcinogenicity	NN
cord-006229-7yoilsho	5722	16	(	(	-LRB-
cord-006229-7yoilsho	5722	17	initiation	initiation	NN
cord-006229-7yoilsho	5722	18	,	,	,
cord-006229-7yoilsho	5722	19	promotion	promotion	NN
cord-006229-7yoilsho	5722	20	,	,	,
cord-006229-7yoilsho	5722	21	post	post	NN
cord-006229-7yoilsho	5722	22	-	-	JJ
cord-006229-7yoilsho	5722	23	promotion	promotion	JJ
cord-006229-7yoilsho	5722	24	phase	phase	NN
cord-006229-7yoilsho	5722	25	)	)	-RRB-
cord-006229-7yoilsho	5722	26	and	and	CC
cord-006229-7yoilsho	5722	27	is	be	VBZ
cord-006229-7yoilsho	5722	28	a	a	DT
cord-006229-7yoilsho	5722	29	promising	promising	JJ
cord-006229-7yoilsho	5722	30	alternative	alternative	NN
cord-006229-7yoilsho	5722	31	to	to	IN
cord-006229-7yoilsho	5722	32	rodent	rodent	NN
cord-006229-7yoilsho	5722	33	bioassays	bioassay	NNS
cord-006229-7yoilsho	5722	34	.	.	.
cord-006229-7yoilsho	5723	1	BALB	BALB	NNP
cord-006229-7yoilsho	5723	2	/	/	SYM
cord-006229-7yoilsho	5723	3	c	c	NN
cord-006229-7yoilsho	5723	4	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	5723	5	are	be	VBP
cord-006229-7yoilsho	5723	6	treated	treat	VBN
cord-006229-7yoilsho	5723	7	for	for	IN
cord-006229-7yoilsho	5723	8	3	3	CD
cord-006229-7yoilsho	5723	9	days	day	NNS
cord-006229-7yoilsho	5723	10	with	with	IN
cord-006229-7yoilsho	5723	11	the	the	DT
cord-006229-7yoilsho	5723	12	tumour	tumour	NN
cord-006229-7yoilsho	5723	13	initiator	initiator	NN
cord-006229-7yoilsho	5723	14	MCA	MCA	NNP
cord-006229-7yoilsho	5723	15	(	(	-LRB-
cord-006229-7yoilsho	5723	16	3-Methylcholanthrene	3-Methylcholanthrene	NNP
cord-006229-7yoilsho	5723	17	)	)	-RRB-
cord-006229-7yoilsho	5723	18	followed	follow	VBN
cord-006229-7yoilsho	5723	19	by	by	IN
cord-006229-7yoilsho	5723	20	13	13	CD
cord-006229-7yoilsho	5723	21	days	day	NNS
cord-006229-7yoilsho	5723	22	with	with	IN
cord-006229-7yoilsho	5723	23	the	the	DT
cord-006229-7yoilsho	5723	24	promotor	promotor	NN
cord-006229-7yoilsho	5723	25	TPA	TPA	NNP
cord-006229-7yoilsho	5723	26	(	(	-LRB-
cord-006229-7yoilsho	5723	27	12-O	12-O	NNP
cord-006229-7yoilsho	5723	28	-	-	HYPH
cord-006229-7yoilsho	5723	29	Tetradecanoylphorbol-13-acetate	tetradecanoylphorbol-13-acetate	NN
cord-006229-7yoilsho	5723	30	)	)	-RRB-
cord-006229-7yoilsho	5723	31	.	.	.
cord-006229-7yoilsho	5724	1	Upon	upon	IN
cord-006229-7yoilsho	5724	2	treatment	treatment	NN
cord-006229-7yoilsho	5724	3	with	with	IN
cord-006229-7yoilsho	5724	4	these	these	DT
cord-006229-7yoilsho	5724	5	chemicals	chemical	NNS
cord-006229-7yoilsho	5724	6	cells	cell	NNS
cord-006229-7yoilsho	5724	7	are	be	VBP
cord-006229-7yoilsho	5724	8	transformed	transform	VBN
cord-006229-7yoilsho	5724	9	into	into	IN
cord-006229-7yoilsho	5724	10	morphologically	morphologically	RB
cord-006229-7yoilsho	5724	11	aberrant	aberrant	JJ
cord-006229-7yoilsho	5724	12	foci	foci	NN
cord-006229-7yoilsho	5724	13	and	and	CC
cord-006229-7yoilsho	5724	14	can	can	MD
cord-006229-7yoilsho	5724	15	be	be	VB
cord-006229-7yoilsho	5724	16	visualized	visualize	VBN
cord-006229-7yoilsho	5724	17	after	after	IN
cord-006229-7yoilsho	5724	18	six	six	CD
cord-006229-7yoilsho	5724	19	weeks	week	NNS
cord-006229-7yoilsho	5724	20	by	by	IN
cord-006229-7yoilsho	5724	21	giemsa	giemsa	NNP
cord-006229-7yoilsho	5724	22	staining	stain	VBG
cord-006229-7yoilsho	5724	23	.	.	.
cord-006229-7yoilsho	5725	1	It	-PRON-	PRP
cord-006229-7yoilsho	5725	2	is	be	VBZ
cord-006229-7yoilsho	5725	3	possible	possible	JJ
cord-006229-7yoilsho	5725	4	to	to	TO
cord-006229-7yoilsho	5725	5	apply	apply	VB
cord-006229-7yoilsho	5725	6	additional	additional	JJ
cord-006229-7yoilsho	5725	7	substances	substance	NNS
cord-006229-7yoilsho	5725	8	during	during	IN
cord-006229-7yoilsho	5725	9	the	the	DT
cord-006229-7yoilsho	5725	10	whole	whole	JJ
cord-006229-7yoilsho	5725	11	assay	assay	NN
cord-006229-7yoilsho	5725	12	or	or	CC
cord-006229-7yoilsho	5725	13	in	in	IN
cord-006229-7yoilsho	5725	14	several	several	JJ
cord-006229-7yoilsho	5725	15	phases	phase	NNS
cord-006229-7yoilsho	5725	16	of	of	IN
cord-006229-7yoilsho	5725	17	transformation	transformation	NN
cord-006229-7yoilsho	5725	18	and	and	CC
cord-006229-7yoilsho	5725	19	evaluate	evaluate	VB
cord-006229-7yoilsho	5725	20	the	the	DT
cord-006229-7yoilsho	5725	21	colony	colony	NN
cord-006229-7yoilsho	5725	22	formation	formation	NN
cord-006229-7yoilsho	5725	23	.	.	.
cord-006229-7yoilsho	5726	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	5726	2	,	,	,
cord-006229-7yoilsho	5726	3	our	-PRON-	PRP$
cord-006229-7yoilsho	5726	4	improved	improved	JJ
cord-006229-7yoilsho	5726	5	protocol	protocol	NN
cord-006229-7yoilsho	5726	6	allows	allow	VBZ
cord-006229-7yoilsho	5726	7	additional	additional	JJ
cord-006229-7yoilsho	5726	8	westernblot	westernblot	NNS
cord-006229-7yoilsho	5726	9	or	or	CC
cord-006229-7yoilsho	5726	10	immunofluorescence	immunofluorescence	NN
cord-006229-7yoilsho	5726	11	analysis	analysis	NN
cord-006229-7yoilsho	5726	12	.	.	.
cord-006229-7yoilsho	5727	1	The	the	DT
cord-006229-7yoilsho	5727	2	influence	influence	NN
cord-006229-7yoilsho	5727	3	on	on	IN
cord-006229-7yoilsho	5727	4	cell	cell	NN
cord-006229-7yoilsho	5727	5	proliferation	proliferation	NN
cord-006229-7yoilsho	5727	6	of	of	IN
cord-006229-7yoilsho	5727	7	different	different	JJ
cord-006229-7yoilsho	5727	8	concentrations	concentration	NNS
cord-006229-7yoilsho	5727	9	of	of	IN
cord-006229-7yoilsho	5727	10	rapamycin	rapamycin	NNS
cord-006229-7yoilsho	5727	11	was	be	VBD
cord-006229-7yoilsho	5727	12	investigated	investigate	VBN
cord-006229-7yoilsho	5727	13	by	by	IN
cord-006229-7yoilsho	5727	14	cell	cell	NN
cord-006229-7yoilsho	5727	15	counting	counting	NN
cord-006229-7yoilsho	5727	16	(	(	-LRB-
cord-006229-7yoilsho	5727	17	living	live	VBG
cord-006229-7yoilsho	5727	18	and	and	CC
cord-006229-7yoilsho	5727	19	dead	dead	JJ
cord-006229-7yoilsho	5727	20	)	)	-RRB-
cord-006229-7yoilsho	5727	21	to	to	TO
cord-006229-7yoilsho	5727	22	choose	choose	VB
cord-006229-7yoilsho	5727	23	a	a	DT
cord-006229-7yoilsho	5727	24	suitable	suitable	JJ
cord-006229-7yoilsho	5727	25	concentration	concentration	NN
cord-006229-7yoilsho	5727	26	for	for	IN
cord-006229-7yoilsho	5727	27	the	the	DT
cord-006229-7yoilsho	5727	28	CTA	CTA	NNP
cord-006229-7yoilsho	5727	29	.	.	.
cord-006229-7yoilsho	5728	1	Performances	performance	NNS
cord-006229-7yoilsho	5728	2	of	of	IN
cord-006229-7yoilsho	5728	3	BALB	BALB	NNP
cord-006229-7yoilsho	5728	4	/	/	SYM
cord-006229-7yoilsho	5728	5	c	c	NNP
cord-006229-7yoilsho	5728	6	CTAs	cta	NNS
cord-006229-7yoilsho	5728	7	with	with	IN
cord-006229-7yoilsho	5728	8	10	10	CD
cord-006229-7yoilsho	5728	9	nM	nm	CD
cord-006229-7yoilsho	5728	10	rapamycin	rapamycin	NNS
cord-006229-7yoilsho	5728	11	showed	show	VBD
cord-006229-7yoilsho	5728	12	,	,	,
cord-006229-7yoilsho	5728	13	contrary	contrary	JJ
cord-006229-7yoilsho	5728	14	to	to	IN
cord-006229-7yoilsho	5728	15	expectations	expectation	NNS
cord-006229-7yoilsho	5728	16	,	,	,
cord-006229-7yoilsho	5728	17	an	an	DT
cord-006229-7yoilsho	5728	18	increase	increase	NN
cord-006229-7yoilsho	5728	19	in	in	IN
cord-006229-7yoilsho	5728	20	cell	cell	NN
cord-006229-7yoilsho	5728	21	transformation	transformation	NN
cord-006229-7yoilsho	5728	22	.	.	.
cord-006229-7yoilsho	5729	1	By	by	IN
cord-006229-7yoilsho	5729	2	administration	administration	NN
cord-006229-7yoilsho	5729	3	of	of	IN
cord-006229-7yoilsho	5729	4	rapamycin	rapamycin	NNP
cord-006229-7yoilsho	5729	5	only	only	RB
cord-006229-7yoilsho	5729	6	in	in	IN
cord-006229-7yoilsho	5729	7	the	the	DT
cord-006229-7yoilsho	5729	8	promotion	promotion	NN
cord-006229-7yoilsho	5729	9	phase	phase	NN
cord-006229-7yoilsho	5729	10	we	-PRON-	PRP
cord-006229-7yoilsho	5729	11	could	could	MD
cord-006229-7yoilsho	5729	12	detect	detect	VB
cord-006229-7yoilsho	5729	13	an	an	DT
cord-006229-7yoilsho	5729	14	increase	increase	NN
cord-006229-7yoilsho	5729	15	in	in	IN
cord-006229-7yoilsho	5729	16	colony	colony	NN
cord-006229-7yoilsho	5729	17	formation	formation	NN
cord-006229-7yoilsho	5729	18	,	,	,
cord-006229-7yoilsho	5729	19	whereas	whereas	IN
cord-006229-7yoilsho	5729	20	a	a	DT
cord-006229-7yoilsho	5729	21	treatment	treatment	NN
cord-006229-7yoilsho	5729	22	with	with	IN
cord-006229-7yoilsho	5729	23	rapamycin	rapamycin	NNS
cord-006229-7yoilsho	5729	24	in	in	IN
cord-006229-7yoilsho	5729	25	the	the	DT
cord-006229-7yoilsho	5729	26	post	post	JJ
cord-006229-7yoilsho	5729	27	-	-	JJ
cord-006229-7yoilsho	5729	28	promotion	promotion	JJ
cord-006229-7yoilsho	5729	29	phase	phase	NN
cord-006229-7yoilsho	5729	30	with	with	IN
cord-006229-7yoilsho	5729	31	already	already	RB
cord-006229-7yoilsho	5729	32	established	establish	VBN
cord-006229-7yoilsho	5729	33	foci	foci	NN
cord-006229-7yoilsho	5729	34	,	,	,
cord-006229-7yoilsho	5729	35	seemed	seem	VBD
cord-006229-7yoilsho	5729	36	to	to	TO
cord-006229-7yoilsho	5729	37	reveal	reveal	VB
cord-006229-7yoilsho	5729	38	its	-PRON-	PRP$
cord-006229-7yoilsho	5729	39	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	5729	40	properties	property	NNS
cord-006229-7yoilsho	5729	41	.	.	.
cord-006229-7yoilsho	5730	1	To	to	TO
cord-006229-7yoilsho	5730	2	better	well	RBR
cord-006229-7yoilsho	5730	3	understand	understand	VB
cord-006229-7yoilsho	5730	4	the	the	DT
cord-006229-7yoilsho	5730	5	role	role	NN
cord-006229-7yoilsho	5730	6	of	of	IN
cord-006229-7yoilsho	5730	7	mTOR	mTOR	NNP
cord-006229-7yoilsho	5730	8	in	in	IN
cord-006229-7yoilsho	5730	9	our	-PRON-	PRP$
cord-006229-7yoilsho	5730	10	cell	cell	NN
cord-006229-7yoilsho	5730	11	transformation	transformation	NN
cord-006229-7yoilsho	5730	12	system	system	NN
cord-006229-7yoilsho	5730	13	we	-PRON-	PRP
cord-006229-7yoilsho	5730	14	used	use	VBD
cord-006229-7yoilsho	5730	15	another	another	DT
cord-006229-7yoilsho	5730	16	mTOR	mTOR	NNP
cord-006229-7yoilsho	5730	17	inhibitor	inhibitor	NN
cord-006229-7yoilsho	5730	18	called	call	VBN
cord-006229-7yoilsho	5730	19	OSI-027	osi-027	RB
cord-006229-7yoilsho	5730	20	.	.	.
cord-006229-7yoilsho	5731	1	Surprisingly	surprisingly	RB
cord-006229-7yoilsho	5731	2	,	,	,
cord-006229-7yoilsho	5731	3	an	an	DT
cord-006229-7yoilsho	5731	4	incubation	incubation	NN
cord-006229-7yoilsho	5731	5	with	with	IN
cord-006229-7yoilsho	5731	6	3	3	CD
cord-006229-7yoilsho	5731	7	µM	µm	NN
cord-006229-7yoilsho	5732	1	OSI-027	osi-027	PRP
cord-006229-7yoilsho	5732	2	led	lead	VBD
cord-006229-7yoilsho	5732	3	to	to	IN
cord-006229-7yoilsho	5732	4	a	a	DT
cord-006229-7yoilsho	5732	5	decrease	decrease	NN
cord-006229-7yoilsho	5732	6	in	in	IN
cord-006229-7yoilsho	5732	7	colony	colony	NN
cord-006229-7yoilsho	5732	8	formation	formation	NN
cord-006229-7yoilsho	5732	9	.	.	.
cord-006229-7yoilsho	5733	1	We	-PRON-	PRP
cord-006229-7yoilsho	5733	2	are	be	VBP
cord-006229-7yoilsho	5733	3	now	now	RB
cord-006229-7yoilsho	5733	4	able	able	JJ
cord-006229-7yoilsho	5733	5	to	to	TO
cord-006229-7yoilsho	5733	6	investigate	investigate	VB
cord-006229-7yoilsho	5733	7	the	the	DT
cord-006229-7yoilsho	5733	8	underlying	underlying	JJ
cord-006229-7yoilsho	5733	9	mechanism	mechanism	NN
cord-006229-7yoilsho	5733	10	with	with	IN
cord-006229-7yoilsho	5733	11	westernblot	westernblot	NNP
cord-006229-7yoilsho	5733	12	and	and	CC
cord-006229-7yoilsho	5733	13	immunofluorescence	immunofluorescence	NN
cord-006229-7yoilsho	5733	14	analysis	analysis	NN
cord-006229-7yoilsho	5733	15	and	and	CC
cord-006229-7yoilsho	5733	16	can	can	MD
cord-006229-7yoilsho	5733	17	compare	compare	VB
cord-006229-7yoilsho	5733	18	regulations	regulation	NNS
cord-006229-7yoilsho	5733	19	of	of	IN
cord-006229-7yoilsho	5733	20	downstream	downstream	JJ
cord-006229-7yoilsho	5733	21	targets	target	NNS
cord-006229-7yoilsho	5733	22	like	like	IN
cord-006229-7yoilsho	5733	23	the	the	DT
cord-006229-7yoilsho	5733	24	marker	marker	NN
cord-006229-7yoilsho	5733	25	of	of	IN
cord-006229-7yoilsho	5733	26	protein	protein	NN
cord-006229-7yoilsho	5733	27	synthesis	synthesis	NN
cord-006229-7yoilsho	5733	28	p	p	NN
cord-006229-7yoilsho	5733	29	-	-	:
cord-006229-7yoilsho	5733	30	S6	S6	NNP
cord-006229-7yoilsho	5733	31	.	.	.
cord-006229-7yoilsho	5734	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	5734	2	investigations	investigation	NNS
cord-006229-7yoilsho	5734	3	revealed	reveal	VBD
cord-006229-7yoilsho	5734	4	different	different	JJ
cord-006229-7yoilsho	5734	5	cell	cell	NN
cord-006229-7yoilsho	5734	6	transformation	transformation	NN
cord-006229-7yoilsho	5734	7	outcomes	outcome	NNS
cord-006229-7yoilsho	5734	8	by	by	IN
cord-006229-7yoilsho	5734	9	comparing	compare	VBG
cord-006229-7yoilsho	5734	10	the	the	DT
cord-006229-7yoilsho	5734	11	two	two	CD
cord-006229-7yoilsho	5734	12	known	know	VBN
cord-006229-7yoilsho	5734	13	mTOR	mTOR	NNP
cord-006229-7yoilsho	5734	14	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	5734	15	rapamycin	rapamycin	VBD
cord-006229-7yoilsho	5734	16	and	and	CC
cord-006229-7yoilsho	5734	17	OSI-027	osi-027	RB
cord-006229-7yoilsho	5734	18	,	,	,
cord-006229-7yoilsho	5734	19	which	which	WDT
cord-006229-7yoilsho	5734	20	need	need	VBP
cord-006229-7yoilsho	5734	21	to	to	TO
cord-006229-7yoilsho	5734	22	be	be	VB
cord-006229-7yoilsho	5734	23	further	further	RB
cord-006229-7yoilsho	5734	24	evaluated	evaluate	VBN
cord-006229-7yoilsho	5734	25	.	.	.
cord-006229-7yoilsho	5735	1	In	in	IN
cord-006229-7yoilsho	5735	2	the	the	DT
cord-006229-7yoilsho	5735	3	ongoing	ongoing	JJ
cord-006229-7yoilsho	5735	4	project	project	NN
cord-006229-7yoilsho	5735	5	we	-PRON-	PRP
cord-006229-7yoilsho	5735	6	want	want	VBP
cord-006229-7yoilsho	5735	7	to	to	TO
cord-006229-7yoilsho	5735	8	detect	detect	VB
cord-006229-7yoilsho	5735	9	differences	difference	NNS
cord-006229-7yoilsho	5735	10	between	between	IN
cord-006229-7yoilsho	5735	11	rapamycin	rapamycin	NN
cord-006229-7yoilsho	5735	12	and	and	CC
cord-006229-7yoilsho	5735	13	OSI-027	OSI-027	VBN
cord-006229-7yoilsho	5735	14	by	by	IN
cord-006229-7yoilsho	5735	15	protein	protein	NN
cord-006229-7yoilsho	5735	16	analysis	analysis	NN
cord-006229-7yoilsho	5735	17	and	and	CC
cord-006229-7yoilsho	5735	18	identify	identify	VB
cord-006229-7yoilsho	5735	19	key	key	JJ
cord-006229-7yoilsho	5735	20	proteins	protein	NNS
cord-006229-7yoilsho	5735	21	,	,	,
cord-006229-7yoilsho	5735	22	which	which	WDT
cord-006229-7yoilsho	5735	23	are	be	VBP
cord-006229-7yoilsho	5735	24	involved	involve	VBN
cord-006229-7yoilsho	5735	25	in	in	IN
cord-006229-7yoilsho	5735	26	this	this	DT
cord-006229-7yoilsho	5735	27	opposed	oppose	VBN
cord-006229-7yoilsho	5735	28	colony	colony	NN
cord-006229-7yoilsho	5735	29	formation	formation	NN
cord-006229-7yoilsho	5735	30	of	of	IN
cord-006229-7yoilsho	5735	31	the	the	DT
cord-006229-7yoilsho	5735	32	BALB	BALB	NNP
cord-006229-7yoilsho	5735	33	/	/	SYM
cord-006229-7yoilsho	5735	34	c	c	NN
cord-006229-7yoilsho	5735	35	cells	cell	NNS
cord-006229-7yoilsho	5735	36	.	.	.
cord-006229-7yoilsho	5736	1	These	these	DT
cord-006229-7yoilsho	5736	2	results	result	NNS
cord-006229-7yoilsho	5736	3	can	can	MD
cord-006229-7yoilsho	5736	4	be	be	VB
cord-006229-7yoilsho	5736	5	helpful	helpful	JJ
cord-006229-7yoilsho	5736	6	to	to	TO
cord-006229-7yoilsho	5736	7	better	well	RBR
cord-006229-7yoilsho	5736	8	understand	understand	VB
cord-006229-7yoilsho	5736	9	mTOR	mTOR	NNP
cord-006229-7yoilsho	5736	10	inhibition	inhibition	NN
cord-006229-7yoilsho	5736	11	in	in	IN
cord-006229-7yoilsho	5736	12	matters	matter	NNS
cord-006229-7yoilsho	5736	13	of	of	IN
cord-006229-7yoilsho	5736	14	tumour	tumour	NN
cord-006229-7yoilsho	5736	15	therapy	therapy	NN
cord-006229-7yoilsho	5736	16	.	.	.
cord-006229-7yoilsho	5737	1	Introduction	introduction	NN
cord-006229-7yoilsho	5737	2	:	:	:
cord-006229-7yoilsho	5738	1	Over	over	IN
cord-006229-7yoilsho	5738	2	the	the	DT
cord-006229-7yoilsho	5738	3	past	past	JJ
cord-006229-7yoilsho	5738	4	50	50	CD
cord-006229-7yoilsho	5738	5	years	year	NNS
cord-006229-7yoilsho	5738	6	,	,	,
cord-006229-7yoilsho	5738	7	the	the	DT
cord-006229-7yoilsho	5738	8	biguanide	biguanide	NNP
cord-006229-7yoilsho	5738	9	compound	compound	NNP
cord-006229-7yoilsho	5738	10	metformin	metformin	NNP
cord-006229-7yoilsho	5738	11	has	have	VBZ
cord-006229-7yoilsho	5738	12	been	be	VBN
cord-006229-7yoilsho	5738	13	widely	widely	RB
cord-006229-7yoilsho	5738	14	prescribed	prescribe	VBN
cord-006229-7yoilsho	5738	15	as	as	IN
cord-006229-7yoilsho	5738	16	an	an	DT
cord-006229-7yoilsho	5738	17	insulin	insulin	NN
cord-006229-7yoilsho	5738	18	sensitizer	sensitizer	NN
cord-006229-7yoilsho	5738	19	in	in	IN
cord-006229-7yoilsho	5738	20	type	type	NN
cord-006229-7yoilsho	5738	21	2	2	CD
cord-006229-7yoilsho	5738	22	diabetes	diabetes	NN
cord-006229-7yoilsho	5738	23	mellitus	mellitus	NN
cord-006229-7yoilsho	5738	24	.	.	.
cord-006229-7yoilsho	5739	1	Interestingly	interestingly	RB
cord-006229-7yoilsho	5739	2	,	,	,
cord-006229-7yoilsho	5739	3	recent	recent	JJ
cord-006229-7yoilsho	5739	4	meta	meta	NNP
cord-006229-7yoilsho	5739	5	-	-	HYPH
cord-006229-7yoilsho	5739	6	analyses	analysis	NNS
cord-006229-7yoilsho	5739	7	of	of	IN
cord-006229-7yoilsho	5739	8	epidemiological	epidemiological	JJ
cord-006229-7yoilsho	5739	9	studies	study	NNS
cord-006229-7yoilsho	5739	10	have	have	VBP
cord-006229-7yoilsho	5739	11	shown	show	VBN
cord-006229-7yoilsho	5739	12	that	that	IN
cord-006229-7yoilsho	5739	13	metformin	metformin	NNP
cord-006229-7yoilsho	5739	14	might	may	MD
cord-006229-7yoilsho	5739	15	be	be	VB
cord-006229-7yoilsho	5739	16	involved	involve	VBN
cord-006229-7yoilsho	5739	17	in	in	IN
cord-006229-7yoilsho	5739	18	risk	risk	NN
cord-006229-7yoilsho	5739	19	reduction	reduction	NN
cord-006229-7yoilsho	5739	20	of	of	IN
cord-006229-7yoilsho	5739	21	carcinogenesis	carcinogenesis	NN
cord-006229-7yoilsho	5739	22	.	.	.
cord-006229-7yoilsho	5740	1	In	in	IN
cord-006229-7yoilsho	5740	2	vitro	vitro	FW
cord-006229-7yoilsho	5740	3	studies	study	NNS
cord-006229-7yoilsho	5740	4	have	have	VBP
cord-006229-7yoilsho	5740	5	described	describe	VBN
cord-006229-7yoilsho	5740	6	AMP	AMP	NNP
cord-006229-7yoilsho	5740	7	-	-	HYPH
cord-006229-7yoilsho	5740	8	activated	activate	VBN
cord-006229-7yoilsho	5740	9	protein	protein	NN
cord-006229-7yoilsho	5740	10	kinase	kinase	NN
cord-006229-7yoilsho	5740	11	(	(	-LRB-
cord-006229-7yoilsho	5740	12	AMPK)-dependent	AMPK)-dependent	NNP
cord-006229-7yoilsho	5740	13	,	,	,
cord-006229-7yoilsho	5740	14	by	by	IN
cord-006229-7yoilsho	5740	15	inhibition	inhibition	NN
cord-006229-7yoilsho	5740	16	of	of	IN
cord-006229-7yoilsho	5740	17	the	the	DT
cord-006229-7yoilsho	5740	18	respiratory	respiratory	JJ
cord-006229-7yoilsho	5740	19	chain	chain	NN
cord-006229-7yoilsho	5740	20	complex	complex	NN
cord-006229-7yoilsho	5741	1	I	-PRON-	PRP
cord-006229-7yoilsho	5741	2	,	,	,
cord-006229-7yoilsho	5741	3	as	as	RB
cord-006229-7yoilsho	5741	4	well	well	RB
cord-006229-7yoilsho	5741	5	as	as	IN
cord-006229-7yoilsho	5741	6	AMPK	AMPK	NNP
cord-006229-7yoilsho	5741	7	-	-	HYPH
cord-006229-7yoilsho	5741	8	independent	independent	JJ
cord-006229-7yoilsho	5741	9	actions	action	NNS
cord-006229-7yoilsho	5741	10	of	of	IN
cord-006229-7yoilsho	5741	11	metformin	metformin	NNP
cord-006229-7yoilsho	5741	12	.	.	.
cord-006229-7yoilsho	5742	1	However	however	RB
cord-006229-7yoilsho	5742	2	,	,	,
cord-006229-7yoilsho	5742	3	the	the	DT
cord-006229-7yoilsho	5742	4	detailed	detailed	JJ
cord-006229-7yoilsho	5742	5	molecular	molecular	JJ
cord-006229-7yoilsho	5742	6	mechanisms	mechanism	NNS
cord-006229-7yoilsho	5742	7	by	by	IN
cord-006229-7yoilsho	5742	8	which	which	WDT
cord-006229-7yoilsho	5742	9	metformin	metformin	NNP
cord-006229-7yoilsho	5742	10	affects	affect	VBZ
cord-006229-7yoilsho	5742	11	cell	cell	NN
cord-006229-7yoilsho	5742	12	proliferation	proliferation	NN
cord-006229-7yoilsho	5742	13	and	and	CC
cord-006229-7yoilsho	5742	14	carcinogenesis	carcinogenesis	NN
cord-006229-7yoilsho	5742	15	have	have	VBP
cord-006229-7yoilsho	5742	16	not	not	RB
cord-006229-7yoilsho	5742	17	been	be	VBN
cord-006229-7yoilsho	5742	18	well	well	RB
cord-006229-7yoilsho	5742	19	identified	identify	VBN
cord-006229-7yoilsho	5742	20	up	up	RP
cord-006229-7yoilsho	5742	21	until	until	IN
cord-006229-7yoilsho	5742	22	now	now	RB
cord-006229-7yoilsho	5742	23	.	.	.
cord-006229-7yoilsho	5743	1	Method	method	NN
cord-006229-7yoilsho	5743	2	:	:	:
cord-006229-7yoilsho	5743	3	To	to	TO
cord-006229-7yoilsho	5743	4	evaluate	evaluate	VB
cord-006229-7yoilsho	5743	5	the	the	DT
cord-006229-7yoilsho	5743	6	protective	protective	JJ
cord-006229-7yoilsho	5743	7	potential	potential	NN
cord-006229-7yoilsho	5743	8	of	of	IN
cord-006229-7yoilsho	5743	9	metformin	metformin	NN
cord-006229-7yoilsho	5743	10	,	,	,
cord-006229-7yoilsho	5743	11	BALB	BALB	NNP
cord-006229-7yoilsho	5743	12	/	/	SYM
cord-006229-7yoilsho	5743	13	c	c	NN
cord-006229-7yoilsho	5743	14	3T3	3t3	CD
cord-006229-7yoilsho	5743	15	cell	cell	NN
cord-006229-7yoilsho	5743	16	transformation	transformation	NN
cord-006229-7yoilsho	5743	17	assays	assay	NNS
cord-006229-7yoilsho	5743	18	were	be	VBD
cord-006229-7yoilsho	5743	19	performed	perform	VBN
cord-006229-7yoilsho	5743	20	.	.	.
cord-006229-7yoilsho	5744	1	This	this	DT
cord-006229-7yoilsho	5744	2	valid	valid	JJ
cord-006229-7yoilsho	5744	3	toxicological	toxicological	JJ
cord-006229-7yoilsho	5744	4	method	method	NN
cord-006229-7yoilsho	5744	5	is	be	VBZ
cord-006229-7yoilsho	5744	6	an	an	DT
cord-006229-7yoilsho	5744	7	alternative	alternative	NN
cord-006229-7yoilsho	5744	8	to	to	IN
cord-006229-7yoilsho	5744	9	in	in	IN
cord-006229-7yoilsho	5744	10	vivo	vivo	FW
cord-006229-7yoilsho	5744	11	carcinogenic	carcinogenic	JJ
cord-006229-7yoilsho	5744	12	testing	testing	NN
cord-006229-7yoilsho	5744	13	and	and	CC
cord-006229-7yoilsho	5744	14	mimics	mimic	VBZ
cord-006229-7yoilsho	5744	15	the	the	DT
cord-006229-7yoilsho	5744	16	different	different	JJ
cord-006229-7yoilsho	5744	17	stages	stage	NNS
cord-006229-7yoilsho	5744	18	of	of	IN
cord-006229-7yoilsho	5744	19	cell	cell	NN
cord-006229-7yoilsho	5744	20	transformation	transformation	NN
cord-006229-7yoilsho	5744	21	during	during	IN
cord-006229-7yoilsho	5744	22	carcinogenesis	carcinogenesis	NN
cord-006229-7yoilsho	5744	23	.	.	.
cord-006229-7yoilsho	5745	1	In	in	IN
cord-006229-7yoilsho	5745	2	detail	detail	NN
cord-006229-7yoilsho	5745	3	,	,	,
cord-006229-7yoilsho	5745	4	mouse	mouse	NN
cord-006229-7yoilsho	5745	5	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	5745	6	are	be	VBP
cord-006229-7yoilsho	5745	7	treated	treat	VBN
cord-006229-7yoilsho	5745	8	with	with	IN
cord-006229-7yoilsho	5745	9	metformin	metformin	NNP
cord-006229-7yoilsho	5745	10	and/or	and/or	CC
cord-006229-7yoilsho	5745	11	the	the	DT
cord-006229-7yoilsho	5745	12	tumour	tumour	NN
cord-006229-7yoilsho	5745	13	initiator	initiator	NN
cord-006229-7yoilsho	5745	14	3-methylcholanthrene	3-methylcholanthrene	CD
cord-006229-7yoilsho	5745	15	(	(	-LRB-
cord-006229-7yoilsho	5745	16	MCA	MCA	NNP
cord-006229-7yoilsho	5745	17	)	)	-RRB-
cord-006229-7yoilsho	5745	18	and	and	CC
cord-006229-7yoilsho	5745	19	the	the	DT
cord-006229-7yoilsho	5745	20	tumour	tumour	NN
cord-006229-7yoilsho	5745	21	promotor	promotor	NN
cord-006229-7yoilsho	5745	22	12-Otetradecanoylphorbol-13-acetate	12-otetradecanoylphorbol-13-acetate	CD
cord-006229-7yoilsho	5745	23	(	(	-LRB-
cord-006229-7yoilsho	5745	24	TPA	TPA	NNP
cord-006229-7yoilsho	5745	25	)	)	-RRB-
cord-006229-7yoilsho	5745	26	.	.	.
cord-006229-7yoilsho	5746	1	In	in	IN
cord-006229-7yoilsho	5746	2	the	the	DT
cord-006229-7yoilsho	5746	3	first	first	JJ
cord-006229-7yoilsho	5746	4	experiment	experiment	NN
cord-006229-7yoilsho	5746	5	several	several	JJ
cord-006229-7yoilsho	5746	6	metformin	metformin	NNP
cord-006229-7yoilsho	5746	7	concentrations	concentration	NNS
cord-006229-7yoilsho	5746	8	(	(	-LRB-
cord-006229-7yoilsho	5746	9	0.1	0.1	CD
cord-006229-7yoilsho	5746	10	-	-	SYM
cord-006229-7yoilsho	5746	11	1	1	CD
cord-006229-7yoilsho	5746	12	mM	mm	CD
cord-006229-7yoilsho	5746	13	metformin	metformin	NNP
cord-006229-7yoilsho	5746	14	)	)	-RRB-
cord-006229-7yoilsho	5746	15	were	be	VBD
cord-006229-7yoilsho	5746	16	applied	apply	VBN
cord-006229-7yoilsho	5746	17	answering	answer	VBG
cord-006229-7yoilsho	5746	18	the	the	DT
cord-006229-7yoilsho	5746	19	question	question	NN
cord-006229-7yoilsho	5746	20	of	of	IN
cord-006229-7yoilsho	5746	21	an	an	DT
cord-006229-7yoilsho	5746	22	effective	effective	JJ
cord-006229-7yoilsho	5746	23	metformin	metformin	NNP
cord-006229-7yoilsho	5746	24	concentration	concentration	NN
cord-006229-7yoilsho	5746	25	.	.	.
cord-006229-7yoilsho	5747	1	Next	next	RB
cord-006229-7yoilsho	5747	2	,	,	,
cord-006229-7yoilsho	5747	3	metformin	metformin	NNP
cord-006229-7yoilsho	5747	4	treatment	treatment	NN
cord-006229-7yoilsho	5747	5	during	during	IN
cord-006229-7yoilsho	5747	6	the	the	DT
cord-006229-7yoilsho	5747	7	different	different	JJ
cord-006229-7yoilsho	5747	8	phases	phase	NNS
cord-006229-7yoilsho	5747	9	of	of	IN
cord-006229-7yoilsho	5747	10	carcinogenesis	carcinogenesis	NN
cord-006229-7yoilsho	5747	11	(	(	-LRB-
cord-006229-7yoilsho	5747	12	initiation	initiation	NN
cord-006229-7yoilsho	5747	13	,	,	,
cord-006229-7yoilsho	5747	14	promotion	promotion	NN
cord-006229-7yoilsho	5747	15	,	,	,
cord-006229-7yoilsho	5747	16	post	post	NN
cord-006229-7yoilsho	5747	17	-	-	JJ
cord-006229-7yoilsho	5747	18	promotion	promotion	JJ
cord-006229-7yoilsho	5747	19	phase	phase	NN
cord-006229-7yoilsho	5747	20	)	)	-RRB-
cord-006229-7yoilsho	5747	21	was	be	VBD
cord-006229-7yoilsho	5747	22	done	do	VBN
cord-006229-7yoilsho	5747	23	determining	determine	VBG
cord-006229-7yoilsho	5747	24	the	the	DT
cord-006229-7yoilsho	5747	25	most	most	RBS
cord-006229-7yoilsho	5747	26	effective	effective	JJ
cord-006229-7yoilsho	5747	27	phase	phase	NN
cord-006229-7yoilsho	5747	28	for	for	IN
cord-006229-7yoilsho	5747	29	an	an	DT
cord-006229-7yoilsho	5747	30	intervention	intervention	NN
cord-006229-7yoilsho	5747	31	,	,	,
cord-006229-7yoilsho	5747	32	i.e.	i.e.	FW
cord-006229-7yoilsho	5747	33	chemopreventive	chemopreventive	NN
cord-006229-7yoilsho	5747	34	or	or	CC
cord-006229-7yoilsho	5747	35	chemotherapeutical	chemotherapeutical	JJ
cord-006229-7yoilsho	5747	36	properties	property	NNS
cord-006229-7yoilsho	5747	37	of	of	IN
cord-006229-7yoilsho	5747	38	metformin	metformin	NNP
cord-006229-7yoilsho	5747	39	.	.	.
cord-006229-7yoilsho	5748	1	Additionally	additionally	RB
cord-006229-7yoilsho	5748	2	,	,	,
cord-006229-7yoilsho	5748	3	the	the	DT
cord-006229-7yoilsho	5748	4	effect	effect	NN
cord-006229-7yoilsho	5748	5	of	of	IN
cord-006229-7yoilsho	5748	6	metformin	metformin	NNP
cord-006229-7yoilsho	5748	7	on	on	IN
cord-006229-7yoilsho	5748	8	the	the	DT
cord-006229-7yoilsho	5748	9	energy	energy	NN
cord-006229-7yoilsho	5748	10	metabolism	metabolism	NN
cord-006229-7yoilsho	5748	11	of	of	IN
cord-006229-7yoilsho	5748	12	the	the	DT
cord-006229-7yoilsho	5748	13	cells	cell	NNS
cord-006229-7yoilsho	5748	14	was	be	VBD
cord-006229-7yoilsho	5748	15	analysed	analyse	VBN
cord-006229-7yoilsho	5748	16	using	use	VBG
cord-006229-7yoilsho	5748	17	various	various	JJ
cord-006229-7yoilsho	5748	18	methods	method	NNS
cord-006229-7yoilsho	5748	19	like	like	IN
cord-006229-7yoilsho	5748	20	immunoblot	immunoblot	NNP
cord-006229-7yoilsho	5748	21	and	and	CC
cord-006229-7yoilsho	5748	22	oxygen	oxygen	NN
cord-006229-7yoilsho	5748	23	measurement	measurement	NN
cord-006229-7yoilsho	5748	24	by	by	IN
cord-006229-7yoilsho	5748	25	Clark	Clark	NNP
cord-006229-7yoilsho	5748	26	electrode	electrode	NN
cord-006229-7yoilsho	5748	27	.	.	.
cord-006229-7yoilsho	5749	1	Results	result	NNS
cord-006229-7yoilsho	5749	2	/	/	SYM
cord-006229-7yoilsho	5749	3	Discussion	discussion	NN
cord-006229-7yoilsho	5749	4	:	:	:
cord-006229-7yoilsho	5750	1	Analysis	analysis	NN
cord-006229-7yoilsho	5750	2	of	of	IN
cord-006229-7yoilsho	5750	3	different	different	JJ
cord-006229-7yoilsho	5750	4	metformin	metformin	NNP
cord-006229-7yoilsho	5750	5	concentrations	concentration	NNS
cord-006229-7yoilsho	5750	6	revealed	reveal	VBD
cord-006229-7yoilsho	5750	7	a	a	DT
cord-006229-7yoilsho	5750	8	concentration	concentration	NN
cord-006229-7yoilsho	5750	9	-	-	HYPH
cord-006229-7yoilsho	5750	10	dependent	dependent	JJ
cord-006229-7yoilsho	5750	11	effect	effect	NN
cord-006229-7yoilsho	5750	12	of	of	IN
cord-006229-7yoilsho	5750	13	metformin	metformin	NNP
cord-006229-7yoilsho	5750	14	.	.	.
cord-006229-7yoilsho	5751	1	In	in	IN
cord-006229-7yoilsho	5751	2	detail	detail	NN
cord-006229-7yoilsho	5751	3	,	,	,
cord-006229-7yoilsho	5751	4	decreased	decrease	VBD
cord-006229-7yoilsho	5751	5	colony	colony	NN
cord-006229-7yoilsho	5751	6	forming	form	VBG
cord-006229-7yoilsho	5751	7	potential	potential	NN
cord-006229-7yoilsho	5751	8	of	of	IN
cord-006229-7yoilsho	5751	9	BALB	BALB	NNP
cord-006229-7yoilsho	5751	10	/	/	SYM
cord-006229-7yoilsho	5751	11	c	c	NN
cord-006229-7yoilsho	5751	12	cells	cell	NNS
cord-006229-7yoilsho	5751	13	was	be	VBD
cord-006229-7yoilsho	5751	14	most	most	RBS
cord-006229-7yoilsho	5751	15	prominent	prominent	JJ
cord-006229-7yoilsho	5751	16	using	use	VBG
cord-006229-7yoilsho	5751	17	1	1	CD
cord-006229-7yoilsho	5751	18	mM	mm	CD
cord-006229-7yoilsho	5751	19	metformin	metformin	NN
cord-006229-7yoilsho	5751	20	.	.	.
cord-006229-7yoilsho	5752	1	This	this	DT
cord-006229-7yoilsho	5752	2	effect	effect	NN
cord-006229-7yoilsho	5752	3	was	be	VBD
cord-006229-7yoilsho	5752	4	not	not	RB
cord-006229-7yoilsho	5752	5	caused	cause	VBN
cord-006229-7yoilsho	5752	6	by	by	IN
cord-006229-7yoilsho	5752	7	growth	growth	NN
cord-006229-7yoilsho	5752	8	inhibition	inhibition	NN
cord-006229-7yoilsho	5752	9	of	of	IN
cord-006229-7yoilsho	5752	10	metformin	metformin	NNP
cord-006229-7yoilsho	5752	11	itself	-PRON-	PRP
cord-006229-7yoilsho	5752	12	since	since	IN
cord-006229-7yoilsho	5752	13	1	1	CD
cord-006229-7yoilsho	5752	14	mM	mm	CD
cord-006229-7yoilsho	5752	15	metformin	metformin	NNP
cord-006229-7yoilsho	5752	16	showed	show	VBD
cord-006229-7yoilsho	5752	17	no	no	DT
cord-006229-7yoilsho	5752	18	growth	growth	NN
cord-006229-7yoilsho	5752	19	inhibitory	inhibitory	JJ
cord-006229-7yoilsho	5752	20	properties	property	NNS
cord-006229-7yoilsho	5752	21	in	in	IN
cord-006229-7yoilsho	5752	22	a	a	DT
cord-006229-7yoilsho	5752	23	cellular	cellular	JJ
cord-006229-7yoilsho	5752	24	growth	growth	NN
cord-006229-7yoilsho	5752	25	pretrial	pretrial	NN
cord-006229-7yoilsho	5752	26	.	.	.
cord-006229-7yoilsho	5753	1	Interestingly	interestingly	RB
cord-006229-7yoilsho	5753	2	,	,	,
cord-006229-7yoilsho	5753	3	the	the	DT
cord-006229-7yoilsho	5753	4	2	2	CD
cord-006229-7yoilsho	5753	5	phase	phase	NN
cord-006229-7yoilsho	5753	6	cell	cell	NN
cord-006229-7yoilsho	5753	7	transformation	transformation	NN
cord-006229-7yoilsho	5753	8	assay	assay	NN
cord-006229-7yoilsho	5753	9	showed	show	VBD
cord-006229-7yoilsho	5753	10	that	that	IN
cord-006229-7yoilsho	5753	11	the	the	DT
cord-006229-7yoilsho	5753	12	metformin	metformin	NNP
cord-006229-7yoilsho	5753	13	effect	effect	NN
cord-006229-7yoilsho	5753	14	is	be	VBZ
cord-006229-7yoilsho	5753	15	more	more	JJR
cord-006229-7yoilsho	5753	16	pronounce	pronounce	NN
cord-006229-7yoilsho	5753	17	in	in	IN
cord-006229-7yoilsho	5753	18	the	the	DT
cord-006229-7yoilsho	5753	19	postpromotion	postpromotion	NN
cord-006229-7yoilsho	5753	20	phase	phase	NN
cord-006229-7yoilsho	5753	21	than	than	IN
cord-006229-7yoilsho	5753	22	in	in	IN
cord-006229-7yoilsho	5753	23	the	the	DT
cord-006229-7yoilsho	5753	24	initiation	initiation	NN
cord-006229-7yoilsho	5753	25	and	and	CC
cord-006229-7yoilsho	5753	26	promotion	promotion	NN
cord-006229-7yoilsho	5753	27	phase	phase	NN
cord-006229-7yoilsho	5753	28	pointing	point	VBG
cord-006229-7yoilsho	5753	29	to	to	IN
cord-006229-7yoilsho	5753	30	a	a	DT
cord-006229-7yoilsho	5753	31	chemotherapeutical	chemotherapeutical	JJ
cord-006229-7yoilsho	5753	32	potential	potential	NN
cord-006229-7yoilsho	5753	33	.	.	.
cord-006229-7yoilsho	5754	1	Investigating	investigate	VBG
cord-006229-7yoilsho	5754	2	several	several	JJ
cord-006229-7yoilsho	5754	3	energy	energy	NN
cord-006229-7yoilsho	5754	4	metabolism	metabolism	NN
cord-006229-7yoilsho	5754	5	parameters	parameter	NNS
cord-006229-7yoilsho	5754	6	,	,	,
cord-006229-7yoilsho	5754	7	the	the	DT
cord-006229-7yoilsho	5754	8	results	result	NNS
cord-006229-7yoilsho	5754	9	indicate	indicate	VBP
cord-006229-7yoilsho	5754	10	that	that	IN
cord-006229-7yoilsho	5754	11	metformin	metformin	NNP
cord-006229-7yoilsho	5754	12	may	may	MD
cord-006229-7yoilsho	5754	13	affect	affect	VB
cord-006229-7yoilsho	5754	14	cell	cell	NN
cord-006229-7yoilsho	5754	15	respiration	respiration	NN
cord-006229-7yoilsho	5754	16	as	as	RB
cord-006229-7yoilsho	5754	17	well	well	RB
cord-006229-7yoilsho	5754	18	as	as	IN
cord-006229-7yoilsho	5754	19	energy	energy	NN
cord-006229-7yoilsho	5754	20	-	-	HYPH
cord-006229-7yoilsho	5754	21	dependent	dependent	JJ
cord-006229-7yoilsho	5754	22	mechanistic	mechanistic	JJ
cord-006229-7yoilsho	5754	23	markers	marker	NNS
cord-006229-7yoilsho	5754	24	like	like	IN
cord-006229-7yoilsho	5754	25	AMPK	AMPK	NNP
cord-006229-7yoilsho	5754	26	.	.	.
cord-006229-7yoilsho	5755	1	The	the	DT
cord-006229-7yoilsho	5755	2	presented	present	VBN
cord-006229-7yoilsho	5755	3	results	result	NNS
cord-006229-7yoilsho	5755	4	support	support	NN
cord-006229-7yoilsho	5755	5	rather	rather	RB
cord-006229-7yoilsho	5755	6	the	the	DT
cord-006229-7yoilsho	5755	7	idea	idea	NN
cord-006229-7yoilsho	5755	8	of	of	IN
cord-006229-7yoilsho	5755	9	the	the	DT
cord-006229-7yoilsho	5755	10	chemotherapeutic	chemotherapeutic	JJ
cord-006229-7yoilsho	5755	11	potential	potential	NN
cord-006229-7yoilsho	5755	12	of	of	IN
cord-006229-7yoilsho	5755	13	metformin	metformin	NNP
cord-006229-7yoilsho	5755	14	than	than	IN
cord-006229-7yoilsho	5755	15	a	a	DT
cord-006229-7yoilsho	5755	16	chemopreventive	chemopreventive	NN
cord-006229-7yoilsho	5755	17	,	,	,
cord-006229-7yoilsho	5755	18	using	use	VBG
cord-006229-7yoilsho	5755	19	1	1	CD
cord-006229-7yoilsho	5755	20	mM	mm	CD
cord-006229-7yoilsho	5755	21	metformin	metformin	NN
cord-006229-7yoilsho	5755	22	.	.	.
cord-006229-7yoilsho	5756	1	The	the	DT
cord-006229-7yoilsho	5756	2	initial	initial	JJ
cord-006229-7yoilsho	5756	3	analysis	analysis	NN
cord-006229-7yoilsho	5756	4	of	of	IN
cord-006229-7yoilsho	5756	5	energy	energy	NN
cord-006229-7yoilsho	5756	6	metabolism	metabolism	NN
cord-006229-7yoilsho	5756	7	markers	marker	NNS
cord-006229-7yoilsho	5756	8	discovered	discover	VBD
cord-006229-7yoilsho	5756	9	interesting	interesting	JJ
cord-006229-7yoilsho	5756	10	starting	starting	NN
cord-006229-7yoilsho	5756	11	points	point	NNS
cord-006229-7yoilsho	5756	12	for	for	IN
cord-006229-7yoilsho	5756	13	further	further	JJ
cord-006229-7yoilsho	5756	14	investigations	investigation	NNS
cord-006229-7yoilsho	5756	15	.	.	.
cord-006229-7yoilsho	5757	1	Johannes	Johannes	NNP
cord-006229-7yoilsho	5757	2	Gutenberg	Gutenberg	NNP
cord-006229-7yoilsho	5757	3	University	University	NNP
cord-006229-7yoilsho	5757	4	,	,	,
cord-006229-7yoilsho	5757	5	Institute	Institute	NNP
cord-006229-7yoilsho	5757	6	of	of	IN
cord-006229-7yoilsho	5757	7	Toxicology	Toxicology	NNP
cord-006229-7yoilsho	5757	8	,	,	,
cord-006229-7yoilsho	5757	9	55131	55131	CD
cord-006229-7yoilsho	5757	10	Mainz	Mainz	NNP
cord-006229-7yoilsho	5757	11	,	,	,
cord-006229-7yoilsho	5757	12	Germany	Germany	NNP
cord-006229-7yoilsho	5757	13	NVP	NVP	NNP
cord-006229-7yoilsho	5757	14	,	,	,
cord-006229-7yoilsho	5757	15	widely	widely	RB
cord-006229-7yoilsho	5757	16	used	use	VBN
cord-006229-7yoilsho	5757	17	e.	e.	NNP
cord-006229-7yoilsho	5757	18	g.	g.	NNP
cord-006229-7yoilsho	5757	19	as	as	IN
cord-006229-7yoilsho	5757	20	a	a	DT
cord-006229-7yoilsho	5757	21	monomer	monomer	NN
cord-006229-7yoilsho	5757	22	for	for	IN
cord-006229-7yoilsho	5757	23	polyvinylpyrrolidones	polyvinylpyrrolidone	NNS
cord-006229-7yoilsho	5757	24	(	(	-LRB-
cord-006229-7yoilsho	5757	25	PVP	PVP	NNP
cord-006229-7yoilsho	5757	26	)	)	-RRB-
cord-006229-7yoilsho	5757	27	with	with	IN
cord-006229-7yoilsho	5757	28	applications	application	NNS
cord-006229-7yoilsho	5757	29	in	in	IN
cord-006229-7yoilsho	5757	30	food	food	NN
cord-006229-7yoilsho	5757	31	technology	technology	NN
cord-006229-7yoilsho	5757	32	or	or	CC
cord-006229-7yoilsho	5757	33	cosmetics	cosmetic	NNS
cord-006229-7yoilsho	5757	34	is	be	VBZ
cord-006229-7yoilsho	5757	35	a	a	DT
cord-006229-7yoilsho	5757	36	known	know	VBN
cord-006229-7yoilsho	5757	37	hepatocarcinogen	hepatocarcinogen	NN
cord-006229-7yoilsho	5757	38	in	in	IN
cord-006229-7yoilsho	5757	39	rats	rat	NNS
cord-006229-7yoilsho	5757	40	after	after	IN
cord-006229-7yoilsho	5757	41	inhalative	inhalative	JJ
cord-006229-7yoilsho	5757	42	exposure	exposure	NN
cord-006229-7yoilsho	5757	43	to	to	IN
cord-006229-7yoilsho	5757	44	5	5	CD
cord-006229-7yoilsho	5757	45	,	,	,
cord-006229-7yoilsho	5757	46	10	10	CD
cord-006229-7yoilsho	5757	47	,	,	,
cord-006229-7yoilsho	5757	48	and	and	CC
cord-006229-7yoilsho	5757	49	20	20	CD
cord-006229-7yoilsho	5757	50	ppm	ppm	NN
cord-006229-7yoilsho	5757	51	for	for	IN
cord-006229-7yoilsho	5757	52	2	2	CD
cord-006229-7yoilsho	5757	53	years	year	NNS
cord-006229-7yoilsho	5757	54	.	.	.
cord-006229-7yoilsho	5758	1	NVP	NVP	NNP
cord-006229-7yoilsho	5758	2	is	be	VBZ
cord-006229-7yoilsho	5758	3	tested	test	VBN
cord-006229-7yoilsho	5758	4	in	in	IN
cord-006229-7yoilsho	5758	5	a	a	DT
cord-006229-7yoilsho	5758	6	battery	battery	NN
cord-006229-7yoilsho	5758	7	of	of	IN
cord-006229-7yoilsho	5758	8	genotoxicity	genotoxicity	NN
cord-006229-7yoilsho	5758	9	assays	assay	NNS
cord-006229-7yoilsho	5758	10	(	(	-LRB-
cord-006229-7yoilsho	5758	11	e.g.	e.g.	IN
cord-006229-7yoilsho	5758	12	Ames	Ames	NNP
cord-006229-7yoilsho	5758	13	,	,	,
cord-006229-7yoilsho	5758	14	HPRT	HPRT	NNP
cord-006229-7yoilsho	5758	15	,	,	,
cord-006229-7yoilsho	5758	16	mouse	mouse	NN
cord-006229-7yoilsho	5758	17	lymphoma	lymphoma	NN
cord-006229-7yoilsho	5758	18	,	,	,
cord-006229-7yoilsho	5758	19	UDS	UDS	NNP
cord-006229-7yoilsho	5758	20	,	,	,
cord-006229-7yoilsho	5758	21	chromosome	chromosome	NN
cord-006229-7yoilsho	5758	22	aberration	aberration	NN
cord-006229-7yoilsho	5758	23	,	,	,
cord-006229-7yoilsho	5758	24	cell	cell	NN
cord-006229-7yoilsho	5758	25	transformation	transformation	NN
cord-006229-7yoilsho	5758	26	,	,	,
cord-006229-7yoilsho	5758	27	micronucleus	micronucleus	NNP
cord-006229-7yoilsho	5758	28	test	test	NN
cord-006229-7yoilsho	5758	29	(	(	-LRB-
cord-006229-7yoilsho	5758	30	MNT	MNT	NNP
cord-006229-7yoilsho	5758	31	)	)	-RRB-
cord-006229-7yoilsho	5758	32	in	in	IN
cord-006229-7yoilsho	5758	33	mice	mice	NN
cord-006229-7yoilsho	5758	34	bone	bone	NN
cord-006229-7yoilsho	5758	35	marrow	marrow	NN
cord-006229-7yoilsho	5758	36	)	)	-RRB-
cord-006229-7yoilsho	5758	37	[	[	-LRB-
cord-006229-7yoilsho	5758	38	1	1	CD
cord-006229-7yoilsho	5758	39	]	]	-RRB-
cord-006229-7yoilsho	5758	40	)	)	-RRB-
cord-006229-7yoilsho	5758	41	that	that	IN
cord-006229-7yoilsho	5758	42	all	all	DT
cord-006229-7yoilsho	5758	43	yielded	yield	VBD
cord-006229-7yoilsho	5758	44	negative	negative	JJ
cord-006229-7yoilsho	5758	45	results	result	NNS
cord-006229-7yoilsho	5758	46	.	.	.
cord-006229-7yoilsho	5759	1	However	however	RB
cord-006229-7yoilsho	5759	2	,	,	,
cord-006229-7yoilsho	5759	3	NVP	NVP	NNP
cord-006229-7yoilsho	5759	4	induces	induce	VBZ
cord-006229-7yoilsho	5759	5	cell	cell	NN
cord-006229-7yoilsho	5759	6	proliferation	proliferation	NN
cord-006229-7yoilsho	5759	7	in	in	IN
cord-006229-7yoilsho	5759	8	liver	liver	NN
cord-006229-7yoilsho	5759	9	(	(	-LRB-
cord-006229-7yoilsho	5759	10	LOAEC	LOAEC	NNP
cord-006229-7yoilsho	5759	11	:	:	:
cord-006229-7yoilsho	5760	1	0.5	0.5	CD
cord-006229-7yoilsho	5760	2	ppm	ppm	NN
cord-006229-7yoilsho	5760	3	)	)	-RRB-
cord-006229-7yoilsho	5760	4	after	after	IN
cord-006229-7yoilsho	5760	5	whole	whole	JJ
cord-006229-7yoilsho	5760	6	body	body	NN
cord-006229-7yoilsho	5760	7	exposure	exposure	NN
cord-006229-7yoilsho	5760	8	to	to	IN
cord-006229-7yoilsho	5760	9	vapor	vapor	NN
cord-006229-7yoilsho	5760	10	[	[	-LRB-
cord-006229-7yoilsho	5760	11	2	2	CD
cord-006229-7yoilsho	5760	12	]	]	-RRB-
cord-006229-7yoilsho	5760	13	.	.	.
cord-006229-7yoilsho	5761	1	To	to	TO
cord-006229-7yoilsho	5761	2	confirm	confirm	VB
cord-006229-7yoilsho	5761	3	the	the	DT
cord-006229-7yoilsho	5761	4	absence	absence	NN
cord-006229-7yoilsho	5761	5	of	of	IN
cord-006229-7yoilsho	5761	6	genotoxicity	genotoxicity	NN
cord-006229-7yoilsho	5761	7	in	in	IN
cord-006229-7yoilsho	5761	8	the	the	DT
cord-006229-7yoilsho	5761	9	context	context	NN
cord-006229-7yoilsho	5761	10	of	of	IN
cord-006229-7yoilsho	5761	11	a	a	DT
cord-006229-7yoilsho	5761	12	potentially	potentially	RB
cord-006229-7yoilsho	5761	13	non	non	JJ
cord-006229-7yoilsho	5761	14	-	-	JJ
cord-006229-7yoilsho	5761	15	genotoxic	genotoxic	JJ
cord-006229-7yoilsho	5761	16	mode	mode	NN
cord-006229-7yoilsho	5761	17	of	of	IN
cord-006229-7yoilsho	5761	18	action	action	NN
cord-006229-7yoilsho	5761	19	,	,	,
cord-006229-7yoilsho	5761	20	a	a	DT
cord-006229-7yoilsho	5761	21	five	five	CD
cord-006229-7yoilsho	5761	22	day	day	NN
cord-006229-7yoilsho	5761	23	whole	whole	JJ
cord-006229-7yoilsho	5761	24	body	body	NN
cord-006229-7yoilsho	5761	25	inhalation	inhalation	NN
cord-006229-7yoilsho	5761	26	study	study	NN
cord-006229-7yoilsho	5761	27	to	to	IN
cord-006229-7yoilsho	5761	28	NVP	NVP	NNP
cord-006229-7yoilsho	5761	29	vapor	vapor	NN
cord-006229-7yoilsho	5761	30	with	with	IN
cord-006229-7yoilsho	5761	31	concentrations	concentration	NNS
cord-006229-7yoilsho	5761	32	of	of	IN
cord-006229-7yoilsho	5761	33	0	0	CD
cord-006229-7yoilsho	5761	34	,	,	,
cord-006229-7yoilsho	5761	35	5	5	CD
cord-006229-7yoilsho	5761	36	,	,	,
cord-006229-7yoilsho	5761	37	10	10	CD
cord-006229-7yoilsho	5761	38	,	,	,
cord-006229-7yoilsho	5761	39	20	20	CD
cord-006229-7yoilsho	5761	40	ppm	ppm	NN
cord-006229-7yoilsho	5761	41	was	be	VBD
cord-006229-7yoilsho	5761	42	conducted	conduct	VBN
cord-006229-7yoilsho	5761	43	in	in	IN
cord-006229-7yoilsho	5761	44	Wistar	Wistar	NNP
cord-006229-7yoilsho	5761	45	rats	rat	NNS
cord-006229-7yoilsho	5761	46	(	(	-LRB-
cord-006229-7yoilsho	5761	47	six	six	CD
cord-006229-7yoilsho	5761	48	animals	animal	NNS
cord-006229-7yoilsho	5761	49	per	per	IN
cord-006229-7yoilsho	5761	50	gender	gender	NN
cord-006229-7yoilsho	5761	51	and	and	CC
cord-006229-7yoilsho	5761	52	group	group	NN
cord-006229-7yoilsho	5761	53	,	,	,
cord-006229-7yoilsho	5761	54	ethyl	ethyl	NN
cord-006229-7yoilsho	5761	55	methanesulfonate	methanesulfonate	NN
cord-006229-7yoilsho	5762	1	200	200	CD
cord-006229-7yoilsho	5762	2	mg	mg	NNP
cord-006229-7yoilsho	5762	3	/	/	SYM
cord-006229-7yoilsho	5762	4	kg	kg	NNP
cord-006229-7yoilsho	5762	5	bw	bw	NNP
cord-006229-7yoilsho	5762	6	p.o	p.o	NNP
cord-006229-7yoilsho	5762	7	.	.	.
cord-006229-7yoilsho	5763	1	as	as	IN
cord-006229-7yoilsho	5763	2	positive	positive	JJ
cord-006229-7yoilsho	5763	3	control	control	NN
cord-006229-7yoilsho	5763	4	)	)	-RRB-
cord-006229-7yoilsho	5763	5	.	.	.
cord-006229-7yoilsho	5764	1	Genotoxicity	Genotoxicity	NNP
cord-006229-7yoilsho	5764	2	was	be	VBD
cord-006229-7yoilsho	5764	3	investigated	investigate	VBN
cord-006229-7yoilsho	5764	4	by	by	IN
cord-006229-7yoilsho	5764	5	the	the	DT
cord-006229-7yoilsho	5764	6	MNT	MNT	NNP
cord-006229-7yoilsho	5764	7	in	in	IN
cord-006229-7yoilsho	5764	8	bone	bone	NN
cord-006229-7yoilsho	5764	9	marrow	marrow	NN
cord-006229-7yoilsho	5764	10	and	and	CC
cord-006229-7yoilsho	5764	11	the	the	DT
cord-006229-7yoilsho	5764	12	Comet	Comet	NNP
cord-006229-7yoilsho	5764	13	Assay	Assay	NNP
cord-006229-7yoilsho	5764	14	(	(	-LRB-
cord-006229-7yoilsho	5764	15	±	±	NNP
cord-006229-7yoilsho	5764	16	FPG	FPG	NNP
cord-006229-7yoilsho	5764	17	)	)	-RRB-
cord-006229-7yoilsho	5764	18	in	in	IN
cord-006229-7yoilsho	5764	19	liver	liver	NN
cord-006229-7yoilsho	5764	20	and	and	CC
cord-006229-7yoilsho	5764	21	lung	lung	NN
cord-006229-7yoilsho	5764	22	.	.	.
cord-006229-7yoilsho	5765	1	Further	further	RB
cord-006229-7yoilsho	5765	2	investigated	investigate	VBN
cord-006229-7yoilsho	5765	3	endpoints	endpoint	NNS
cord-006229-7yoilsho	5765	4	related	relate	VBN
cord-006229-7yoilsho	5765	5	to	to	IN
cord-006229-7yoilsho	5765	6	possible	possible	JJ
cord-006229-7yoilsho	5765	7	non	non	JJ
cord-006229-7yoilsho	5765	8	-	-	JJ
cord-006229-7yoilsho	5765	9	hepatogenotoxic	hepatogenotoxic	JJ
cord-006229-7yoilsho	5765	10	MOA	MOA	NNP
cord-006229-7yoilsho	5765	11	were	be	VBD
cord-006229-7yoilsho	5765	12	:	:	:
cord-006229-7yoilsho	5765	13	enzyme	enzyme	NN
cord-006229-7yoilsho	5765	14	induction	induction	NN
cord-006229-7yoilsho	5765	15	(	(	-LRB-
cord-006229-7yoilsho	5765	16	EROD	EROD	NNP
cord-006229-7yoilsho	5765	17	,	,	,
cord-006229-7yoilsho	5765	18	PROD	PROD	NNP
cord-006229-7yoilsho	5765	19	,	,	,
cord-006229-7yoilsho	5765	20	BROD	BROD	NNP
cord-006229-7yoilsho	5765	21	)	)	-RRB-
cord-006229-7yoilsho	5765	22	,	,	,
cord-006229-7yoilsho	5765	23	oxidative	oxidative	JJ
cord-006229-7yoilsho	5765	24	stress	stress	NN
cord-006229-7yoilsho	5765	25	(	(	-LRB-
cord-006229-7yoilsho	5765	26	GSH-	GSH-	NNP
cord-006229-7yoilsho	5765	27	,	,	,
cord-006229-7yoilsho	5765	28	GSSG-	gssg-	NN
cord-006229-7yoilsho	5765	29	,	,	,
cord-006229-7yoilsho	5765	30	non	non	JJ
cord-006229-7yoilsho	5765	31	-	-	JJ
cord-006229-7yoilsho	5765	32	protein	protein	JJ
cord-006229-7yoilsho	5765	33	sulfhydryl	sulfhydryl	NN
cord-006229-7yoilsho	5765	34	group	group	NN
cord-006229-7yoilsho	5765	35	level	level	NN
cord-006229-7yoilsho	5765	36	)	)	-RRB-
cord-006229-7yoilsho	5765	37	,	,	,
cord-006229-7yoilsho	5765	38	and	and	CC
cord-006229-7yoilsho	5765	39	peroxisome	peroxisome	NN
cord-006229-7yoilsho	5765	40	proliferation	proliferation	NN
cord-006229-7yoilsho	5765	41	(	(	-LRB-
cord-006229-7yoilsho	5765	42	CYP4A	CYP4A	NNP
cord-006229-7yoilsho	5765	43	,	,	,
cord-006229-7yoilsho	5765	44	cyanide	cyanide	NN
cord-006229-7yoilsho	5765	45	-	-	HYPH
cord-006229-7yoilsho	5765	46	insensitive	insensitive	JJ
cord-006229-7yoilsho	5765	47	palmitoyl	palmitoyl	JJ
cord-006229-7yoilsho	5765	48	-	-	HYPH
cord-006229-7yoilsho	5765	49	CoA	coa	NN
cord-006229-7yoilsho	5765	50	-	-	HYPH
cord-006229-7yoilsho	5765	51	oxidase	oxidase	NN
cord-006229-7yoilsho	5765	52	)	)	-RRB-
cord-006229-7yoilsho	5765	53	.	.	.
cord-006229-7yoilsho	5766	1	At	at	IN
cord-006229-7yoilsho	5766	2	carcinogenic	carcinogenic	JJ
cord-006229-7yoilsho	5766	3	inhalative	inhalative	JJ
cord-006229-7yoilsho	5766	4	doses	dose	NNS
cord-006229-7yoilsho	5766	5	,	,	,
cord-006229-7yoilsho	5766	6	the	the	DT
cord-006229-7yoilsho	5766	7	results	result	NNS
cord-006229-7yoilsho	5766	8	of	of	IN
cord-006229-7yoilsho	5766	9	this	this	DT
cord-006229-7yoilsho	5766	10	study	study	NN
cord-006229-7yoilsho	5766	11	proved	prove	VBD
cord-006229-7yoilsho	5766	12	the	the	DT
cord-006229-7yoilsho	5766	13	absence	absence	NN
cord-006229-7yoilsho	5766	14	of	of	IN
cord-006229-7yoilsho	5766	15	genotoxicity	genotoxicity	NN
cord-006229-7yoilsho	5766	16	in	in	IN
cord-006229-7yoilsho	5766	17	lung	lung	NN
cord-006229-7yoilsho	5766	18	,	,	,
cord-006229-7yoilsho	5766	19	liver	liver	NN
cord-006229-7yoilsho	5766	20	and	and	CC
cord-006229-7yoilsho	5766	21	bone	bone	NN
cord-006229-7yoilsho	5766	22	marrow	marrow	NN
cord-006229-7yoilsho	5766	23	as	as	IN
cord-006229-7yoilsho	5766	24	neither	neither	CC
cord-006229-7yoilsho	5766	25	the	the	DT
cord-006229-7yoilsho	5766	26	tail	tail	NN
cord-006229-7yoilsho	5766	27	intensity	intensity	NN
cord-006229-7yoilsho	5766	28	in	in	IN
cord-006229-7yoilsho	5766	29	the	the	DT
cord-006229-7yoilsho	5766	30	Comet	Comet	NNP
cord-006229-7yoilsho	5766	31	Assay	Assay	NNP
cord-006229-7yoilsho	5766	32	nor	nor	CC
cord-006229-7yoilsho	5766	33	the	the	DT
cord-006229-7yoilsho	5766	34	number	number	NN
cord-006229-7yoilsho	5766	35	of	of	IN
cord-006229-7yoilsho	5766	36	micronuclei	micronuclei	NNP
cord-006229-7yoilsho	5766	37	in	in	IN
cord-006229-7yoilsho	5766	38	the	the	DT
cord-006229-7yoilsho	5766	39	MNT	MNT	NNP
cord-006229-7yoilsho	5766	40	was	be	VBD
cord-006229-7yoilsho	5766	41	increased	increase	VBN
cord-006229-7yoilsho	5766	42	compared	compare	VBN
cord-006229-7yoilsho	5766	43	to	to	IN
cord-006229-7yoilsho	5766	44	the	the	DT
cord-006229-7yoilsho	5766	45	controls	control	NNS
cord-006229-7yoilsho	5766	46	.	.	.
cord-006229-7yoilsho	5767	1	However	however	RB
cord-006229-7yoilsho	5767	2	,	,	,
cord-006229-7yoilsho	5767	3	also	also	RB
cord-006229-7yoilsho	5767	4	the	the	DT
cord-006229-7yoilsho	5767	5	non	non	JJ
cord-006229-7yoilsho	5767	6	-	-	JJ
cord-006229-7yoilsho	5767	7	genotoxic	genotoxic	JJ
cord-006229-7yoilsho	5767	8	parameters	parameter	NNS
cord-006229-7yoilsho	5767	9	(	(	-LRB-
cord-006229-7yoilsho	5767	10	CYP	CYP	NNP
cord-006229-7yoilsho	5767	11	-	-	HYPH
cord-006229-7yoilsho	5767	12	enzyme	enzyme	NN
cord-006229-7yoilsho	5767	13	activity	activity	NN
cord-006229-7yoilsho	5767	14	,	,	,
cord-006229-7yoilsho	5767	15	glutathione	glutathione	NN
cord-006229-7yoilsho	5767	16	levels	level	NNS
cord-006229-7yoilsho	5767	17	,	,	,
cord-006229-7yoilsho	5767	18	cyanide	cyanide	NN
cord-006229-7yoilsho	5767	19	-	-	HYPH
cord-006229-7yoilsho	5767	20	insensitive	insensitive	JJ
cord-006229-7yoilsho	5767	21	-	-	HYPH
cord-006229-7yoilsho	5767	22	palmitoyl	palmitoyl	JJ
cord-006229-7yoilsho	5767	23	-	-	HYPH
cord-006229-7yoilsho	5767	24	CoA	coa	NN
cord-006229-7yoilsho	5767	25	-	-	HYPH
cord-006229-7yoilsho	5767	26	oxidase	oxidase	NN
cord-006229-7yoilsho	5767	27	)	)	-RRB-
cord-006229-7yoilsho	5767	28	were	be	VBD
cord-006229-7yoilsho	5767	29	not	not	RB
cord-006229-7yoilsho	5767	30	affected	affect	VBN
cord-006229-7yoilsho	5767	31	by	by	IN
cord-006229-7yoilsho	5767	32	NVP	NVP	NNP
cord-006229-7yoilsho	5767	33	-	-	HYPH
cord-006229-7yoilsho	5767	34	treatment	treatment	NN
cord-006229-7yoilsho	5767	35	.	.	.
cord-006229-7yoilsho	5768	1	As	as	IN
cord-006229-7yoilsho	5768	2	potential	potential	JJ
cord-006229-7yoilsho	5768	3	metabolic	metabolic	JJ
cord-006229-7yoilsho	5768	4	activation	activation	NN
cord-006229-7yoilsho	5768	5	can	can	MD
cord-006229-7yoilsho	5768	6	not	not	RB
cord-006229-7yoilsho	5768	7	be	be	VB
cord-006229-7yoilsho	5768	8	excluded	exclude	VBN
cord-006229-7yoilsho	5768	9	and	and	CC
cord-006229-7yoilsho	5768	10	may	may	MD
cord-006229-7yoilsho	5768	11	essentially	essentially	RB
cord-006229-7yoilsho	5768	12	contribute	contribute	VB
cord-006229-7yoilsho	5768	13	to	to	IN
cord-006229-7yoilsho	5768	14	the	the	DT
cord-006229-7yoilsho	5768	15	understanding	understanding	NN
cord-006229-7yoilsho	5768	16	of	of	IN
cord-006229-7yoilsho	5768	17	the	the	DT
cord-006229-7yoilsho	5768	18	carcinogenic	carcinogenic	JJ
cord-006229-7yoilsho	5768	19	mechanism	mechanism	NN
cord-006229-7yoilsho	5768	20	,	,	,
cord-006229-7yoilsho	5768	21	in	in	IN
cord-006229-7yoilsho	5768	22	vitro	vitro	FW
cord-006229-7yoilsho	5768	23	investigations	investigation	NNS
cord-006229-7yoilsho	5768	24	in	in	IN
cord-006229-7yoilsho	5768	25	rat	rat	NN
cord-006229-7yoilsho	5768	26	liver	liver	NN
cord-006229-7yoilsho	5768	27	systems	system	NNS
cord-006229-7yoilsho	5768	28	(	(	-LRB-
cord-006229-7yoilsho	5768	29	subcellular	subcellular	JJ
cord-006229-7yoilsho	5768	30	fractions	fraction	NNS
cord-006229-7yoilsho	5768	31	,	,	,
cord-006229-7yoilsho	5768	32	hepatocytes	hepatocyte	NNS
cord-006229-7yoilsho	5768	33	,	,	,
cord-006229-7yoilsho	5768	34	precision	precision	NN
cord-006229-7yoilsho	5768	35	cut	cut	VBD
cord-006229-7yoilsho	5768	36	liver	liver	NN
cord-006229-7yoilsho	5768	37	slices	slice	NNS
cord-006229-7yoilsho	5768	38	(	(	-LRB-
cord-006229-7yoilsho	5768	39	PCLS	PCLS	NNP
cord-006229-7yoilsho	5768	40	)	)	-RRB-
cord-006229-7yoilsho	5768	41	)	)	-RRB-
cord-006229-7yoilsho	5768	42	were	be	VBD
cord-006229-7yoilsho	5768	43	performed	perform	VBN
cord-006229-7yoilsho	5768	44	additionally	additionally	RB
cord-006229-7yoilsho	5768	45	.	.	.
cord-006229-7yoilsho	5769	1	Up	up	IN
cord-006229-7yoilsho	5769	2	to	to	IN
cord-006229-7yoilsho	5769	3	now	now	RB
cord-006229-7yoilsho	5769	4	,	,	,
cord-006229-7yoilsho	5769	5	2-pyrrolidone	2-pyrrolidone	CD
cord-006229-7yoilsho	5769	6	is	be	VBZ
cord-006229-7yoilsho	5769	7	the	the	DT
cord-006229-7yoilsho	5769	8	only	only	RB
cord-006229-7yoilsho	5769	9	identified	identify	VBN
cord-006229-7yoilsho	5769	10	in	in	IN
cord-006229-7yoilsho	5769	11	vitro	vitro	FW
cord-006229-7yoilsho	5769	12	metabolite	metabolite	NN
cord-006229-7yoilsho	5769	13	.	.	.
cord-006229-7yoilsho	5770	1	As	as	IN
cord-006229-7yoilsho	5770	2	these	these	DT
cord-006229-7yoilsho	5770	3	results	result	NNS
cord-006229-7yoilsho	5770	4	can	can	MD
cord-006229-7yoilsho	5770	5	not	not	RB
cord-006229-7yoilsho	5770	6	mimic	mimic	VB
cord-006229-7yoilsho	5770	7	the	the	DT
cord-006229-7yoilsho	5770	8	in	in	IN
cord-006229-7yoilsho	5770	9	vivo	vivo	NN
cord-006229-7yoilsho	5770	10	situation	situation	NN
cord-006229-7yoilsho	5770	11	of	of	IN
cord-006229-7yoilsho	5770	12	two	two	CD
cord-006229-7yoilsho	5770	13	described	describe	VBN
cord-006229-7yoilsho	5770	14	,	,	,
cord-006229-7yoilsho	5770	15	ring	ring	NN
cord-006229-7yoilsho	5770	16	-	-	HYPH
cord-006229-7yoilsho	5770	17	and	and	CC
cord-006229-7yoilsho	5770	18	vinylmajority	vinylmajority	NN
cord-006229-7yoilsho	5770	19	containing	contain	VBG
cord-006229-7yoilsho	5770	20	unidentified	unidentified	JJ
cord-006229-7yoilsho	5770	21	metabolites	metabolite	NNS
cord-006229-7yoilsho	5770	22	[	[	-LRB-
cord-006229-7yoilsho	5770	23	3	3	CD
cord-006229-7yoilsho	5770	24	]	]	-RRB-
cord-006229-7yoilsho	5771	1	detailed	detailed	JJ
cord-006229-7yoilsho	5771	2	investigations	investigation	NNS
cord-006229-7yoilsho	5771	3	on	on	IN
cord-006229-7yoilsho	5771	4	metabolism	metabolism	NN
cord-006229-7yoilsho	5771	5	may	may	MD
cord-006229-7yoilsho	5771	6	be	be	VB
cord-006229-7yoilsho	5771	7	a	a	DT
cord-006229-7yoilsho	5771	8	future	future	JJ
cord-006229-7yoilsho	5771	9	perspective	perspective	NN
cord-006229-7yoilsho	5771	10	to	to	TO
cord-006229-7yoilsho	5771	11	approach	approach	VB
cord-006229-7yoilsho	5771	12	the	the	DT
cord-006229-7yoilsho	5771	13	overall	overall	JJ
cord-006229-7yoilsho	5771	14	understanding	understanding	NN
cord-006229-7yoilsho	5771	15	of	of	IN
cord-006229-7yoilsho	5771	16	the	the	DT
cord-006229-7yoilsho	5771	17	carcinogenic	carcinogenic	JJ
cord-006229-7yoilsho	5771	18	mechanism	mechanism	NN
cord-006229-7yoilsho	5771	19	of	of	IN
cord-006229-7yoilsho	5771	20	NVP	NVP	NNP
cord-006229-7yoilsho	5771	21	.	.	.
cord-006229-7yoilsho	5772	1	Introduction	introduction	NN
cord-006229-7yoilsho	5772	2	:	:	:
cord-006229-7yoilsho	5773	1	In	in	IN
cord-006229-7yoilsho	5773	2	ischemic	ischemic	JJ
cord-006229-7yoilsho	5773	3	conditions	condition	NNS
cord-006229-7yoilsho	5773	4	such	such	JJ
cord-006229-7yoilsho	5773	5	as	as	IN
cord-006229-7yoilsho	5773	6	wound	wind	VBN
cord-006229-7yoilsho	5773	7	healing	healing	NN
cord-006229-7yoilsho	5773	8	and	and	CC
cord-006229-7yoilsho	5773	9	myocardial	myocardial	JJ
cord-006229-7yoilsho	5773	10	infarction	infarction	NN
cord-006229-7yoilsho	5773	11	,	,	,
cord-006229-7yoilsho	5773	12	new	new	JJ
cord-006229-7yoilsho	5773	13	vessels	vessel	NNS
cord-006229-7yoilsho	5773	14	are	be	VBP
cord-006229-7yoilsho	5773	15	generated	generate	VBN
cord-006229-7yoilsho	5773	16	by	by	IN
cord-006229-7yoilsho	5773	17	vasculogenesis	vasculogenesis	NN
cord-006229-7yoilsho	5773	18	and	and	CC
cord-006229-7yoilsho	5773	19	angiogenesis	angiogenesis	NN
cord-006229-7yoilsho	5773	20	.	.	.
cord-006229-7yoilsho	5774	1	These	these	DT
cord-006229-7yoilsho	5774	2	processes	process	NNS
cord-006229-7yoilsho	5774	3	are	be	VBP
cord-006229-7yoilsho	5774	4	stimulated	stimulate	VBN
cord-006229-7yoilsho	5774	5	by	by	IN
cord-006229-7yoilsho	5774	6	the	the	DT
cord-006229-7yoilsho	5774	7	signalling	signal	VBG
cord-006229-7yoilsho	5774	8	peptide	peptide	NN
cord-006229-7yoilsho	5774	9	vascular	vascular	JJ
cord-006229-7yoilsho	5774	10	endothelial	endothelial	JJ
cord-006229-7yoilsho	5774	11	growth	growth	NN
cord-006229-7yoilsho	5774	12	factor	factor	NN
cord-006229-7yoilsho	5774	13	which	which	WDT
cord-006229-7yoilsho	5774	14	therefore	therefore	RB
cord-006229-7yoilsho	5774	15	has	have	VBZ
cord-006229-7yoilsho	5774	16	been	be	VBN
cord-006229-7yoilsho	5774	17	proposed	propose	VBN
cord-006229-7yoilsho	5774	18	as	as	IN
cord-006229-7yoilsho	5774	19	a	a	DT
cord-006229-7yoilsho	5774	20	promising	promising	JJ
cord-006229-7yoilsho	5774	21	compound	compound	NN
cord-006229-7yoilsho	5774	22	for	for	IN
cord-006229-7yoilsho	5774	23	the	the	DT
cord-006229-7yoilsho	5774	24	treatment	treatment	NN
cord-006229-7yoilsho	5774	25	of	of	IN
cord-006229-7yoilsho	5774	26	ischemic	ischemic	JJ
cord-006229-7yoilsho	5774	27	conditions	condition	NNS
cord-006229-7yoilsho	5774	28	.	.	.
cord-006229-7yoilsho	5775	1	However	however	RB
cord-006229-7yoilsho	5775	2	,	,	,
cord-006229-7yoilsho	5775	3	results	result	NNS
cord-006229-7yoilsho	5775	4	of	of	IN
cord-006229-7yoilsho	5775	5	respective	respective	JJ
cord-006229-7yoilsho	5775	6	clinical	clinical	JJ
cord-006229-7yoilsho	5775	7	studies	study	NNS
cord-006229-7yoilsho	5775	8	have	have	VBP
cord-006229-7yoilsho	5775	9	not	not	RB
cord-006229-7yoilsho	5775	10	been	be	VBN
cord-006229-7yoilsho	5775	11	fully	fully	RB
cord-006229-7yoilsho	5775	12	convincing	convincing	JJ
cord-006229-7yoilsho	5775	13	yet	yet	RB
cord-006229-7yoilsho	5775	14	.	.	.
cord-006229-7yoilsho	5776	1	Here	here	RB
cord-006229-7yoilsho	5776	2	,	,	,
cord-006229-7yoilsho	5776	3	we	-PRON-	PRP
cord-006229-7yoilsho	5776	4	investigated	investigate	VBD
cord-006229-7yoilsho	5776	5	principles	principle	NNS
cord-006229-7yoilsho	5776	6	underlying	underlie	VBG
cord-006229-7yoilsho	5776	7	the	the	DT
cord-006229-7yoilsho	5776	8	selforganization	selforganization	NN
cord-006229-7yoilsho	5776	9	of	of	IN
cord-006229-7yoilsho	5776	10	newly	newly	RB
cord-006229-7yoilsho	5776	11	formed	form	VBN
cord-006229-7yoilsho	5776	12	vessels	vessel	NNS
cord-006229-7yoilsho	5776	13	to	to	IN
cord-006229-7yoilsho	5776	14	functionally	functionally	RB
cord-006229-7yoilsho	5776	15	adequate	adequate	JJ
cord-006229-7yoilsho	5776	16	microvascular	microvascular	JJ
cord-006229-7yoilsho	5776	17	networks	network	NNS
cord-006229-7yoilsho	5776	18	indispensable	indispensable	JJ
cord-006229-7yoilsho	5776	19	for	for	IN
cord-006229-7yoilsho	5776	20	proper	proper	JJ
cord-006229-7yoilsho	5776	21	tissue	tissue	NN
cord-006229-7yoilsho	5776	22	substrate	substrate	NN
cord-006229-7yoilsho	5776	23	supply	supply	NN
cord-006229-7yoilsho	5776	24	.	.	.
cord-006229-7yoilsho	5777	1	Intravital	Intravital	NNP
cord-006229-7yoilsho	5777	2	microscopy	microscopy	NNS
cord-006229-7yoilsho	5777	3	of	of	IN
cord-006229-7yoilsho	5777	4	the	the	DT
cord-006229-7yoilsho	5777	5	chick	chick	NN
cord-006229-7yoilsho	5777	6	chorioallantoic	chorioallantoic	NNP
cord-006229-7yoilsho	5777	7	membrane	membrane	NNP
cord-006229-7yoilsho	5777	8	(	(	-LRB-
cord-006229-7yoilsho	5777	9	CAM	CAM	NNP
cord-006229-7yoilsho	5777	10	)	)	-RRB-
cord-006229-7yoilsho	5777	11	,	,	,
cord-006229-7yoilsho	5777	12	a	a	DT
cord-006229-7yoilsho	5777	13	non	non	JJ
cord-006229-7yoilsho	5777	14	animal	animal	NN
cord-006229-7yoilsho	5777	15	model	model	NN
cord-006229-7yoilsho	5777	16	as	as	IN
cord-006229-7yoilsho	5777	17	defined	define	VBN
cord-006229-7yoilsho	5777	18	by	by	IN
cord-006229-7yoilsho	5777	19	the	the	DT
cord-006229-7yoilsho	5777	20	American	American	NNP
cord-006229-7yoilsho	5777	21	National	National	NNP
cord-006229-7yoilsho	5777	22	Institutes	Institutes	NNPS
cord-006229-7yoilsho	5777	23	of	of	IN
cord-006229-7yoilsho	5777	24	Health	Health	NNP
cord-006229-7yoilsho	5777	25	's	's	POS
cord-006229-7yoilsho	5777	26	Office	Office	NNP
cord-006229-7yoilsho	5777	27	for	for	IN
cord-006229-7yoilsho	5777	28	Protection	Protection	NNP
cord-006229-7yoilsho	5777	29	from	from	IN
cord-006229-7yoilsho	5777	30	Research	Research	NNP
cord-006229-7yoilsho	5777	31	Risks	Risks	NNPS
cord-006229-7yoilsho	5777	32	,	,	,
cord-006229-7yoilsho	5777	33	was	be	VBD
cord-006229-7yoilsho	5777	34	used	use	VBN
cord-006229-7yoilsho	5777	35	to	to	TO
cord-006229-7yoilsho	5777	36	study	study	VB
cord-006229-7yoilsho	5777	37	peripheral	peripheral	JJ
cord-006229-7yoilsho	5777	38	expansion	expansion	NN
cord-006229-7yoilsho	5777	39	of	of	IN
cord-006229-7yoilsho	5777	40	existing	exist	VBG
cord-006229-7yoilsho	5777	41	arteriolar	arteriolar	JJ
cord-006229-7yoilsho	5777	42	and	and	CC
cord-006229-7yoilsho	5777	43	venular	venular	JJ
cord-006229-7yoilsho	5777	44	trees	tree	NNS
cord-006229-7yoilsho	5777	45	by	by	IN
cord-006229-7yoilsho	5777	46	recruiting	recruit	VBG
cord-006229-7yoilsho	5777	47	segments	segment	NNS
cord-006229-7yoilsho	5777	48	of	of	IN
cord-006229-7yoilsho	5777	49	the	the	DT
cord-006229-7yoilsho	5777	50	dense	dense	JJ
cord-006229-7yoilsho	5777	51	polygonal	polygonal	JJ
cord-006229-7yoilsho	5777	52	capillary	capillary	NN
cord-006229-7yoilsho	5777	53	mesh	mesh	NN
cord-006229-7yoilsho	5777	54	.	.	.
cord-006229-7yoilsho	5778	1	This	this	DT
cord-006229-7yoilsho	5778	2	process	process	NN
cord-006229-7yoilsho	5778	3	we	-PRON-	PRP
cord-006229-7yoilsho	5778	4	call	call	VBP
cord-006229-7yoilsho	5778	5	"	"	``
cord-006229-7yoilsho	5778	6	Emerging	emerge	VBG
cord-006229-7yoilsho	5778	7	angiogenesis	angiogenesis	NN
cord-006229-7yoilsho	5778	8	"	"	''
cord-006229-7yoilsho	5778	9	.	.	.
cord-006229-7yoilsho	5779	1	Methods	method	NNS
cord-006229-7yoilsho	5779	2	:	:	:
cord-006229-7yoilsho	5780	1	White	white	JJ
cord-006229-7yoilsho	5780	2	leghorn	leghorn	NNP
cord-006229-7yoilsho	5780	3	chicken	chicken	NN
cord-006229-7yoilsho	5780	4	eggs	egg	NNS
cord-006229-7yoilsho	5780	5	were	be	VBD
cord-006229-7yoilsho	5780	6	put	put	VBN
cord-006229-7yoilsho	5780	7	into	into	IN
cord-006229-7yoilsho	5780	8	incubators	incubator	NNS
cord-006229-7yoilsho	5780	9	on	on	IN
cord-006229-7yoilsho	5780	10	embryonic	embryonic	JJ
cord-006229-7yoilsho	5780	11	day	day	NN
cord-006229-7yoilsho	5780	12	0	0	CD
cord-006229-7yoilsho	5780	13	(	(	-LRB-
cord-006229-7yoilsho	5780	14	E0	E0	NNP
cord-006229-7yoilsho	5780	15	)	)	-RRB-
cord-006229-7yoilsho	5780	16	at	at	IN
cord-006229-7yoilsho	5780	17	37.5	37.5	CD
cord-006229-7yoilsho	5780	18	°	°	NN
cord-006229-7yoilsho	5780	19	C	c	NN
cord-006229-7yoilsho	5780	20	and	and	CC
cord-006229-7yoilsho	5780	21	82	82	CD
cord-006229-7yoilsho	5780	22	%	%	NN
cord-006229-7yoilsho	5780	23	humidity	humidity	NN
cord-006229-7yoilsho	5780	24	.	.	.
cord-006229-7yoilsho	5781	1	On	on	IN
cord-006229-7yoilsho	5781	2	E3	E3	NNP
cord-006229-7yoilsho	5781	3	,	,	,
cord-006229-7yoilsho	5781	4	the	the	DT
cord-006229-7yoilsho	5781	5	eggs	egg	NNS
cord-006229-7yoilsho	5781	6	were	be	VBD
cord-006229-7yoilsho	5781	7	cracked	crack	VBN
cord-006229-7yoilsho	5781	8	open	open	JJ
cord-006229-7yoilsho	5781	9	and	and	CC
cord-006229-7yoilsho	5781	10	transferred	transfer	VBN
cord-006229-7yoilsho	5781	11	into	into	IN
cord-006229-7yoilsho	5781	12	petri	petri	JJ
cord-006229-7yoilsho	5781	13	dishes	dish	NNS
cord-006229-7yoilsho	5781	14	.	.	.
cord-006229-7yoilsho	5782	1	On	on	IN
cord-006229-7yoilsho	5782	2	E10	E10	NNP
cord-006229-7yoilsho	5782	3	,	,	,
cord-006229-7yoilsho	5782	4	CAM	CAM	NNP
cord-006229-7yoilsho	5782	5	microcirculation	microcirculation	NN
cord-006229-7yoilsho	5782	6	was	be	VBD
cord-006229-7yoilsho	5782	7	recorded	record	VBN
cord-006229-7yoilsho	5782	8	using	use	VBG
cord-006229-7yoilsho	5782	9	time	time	NN
cord-006229-7yoilsho	5782	10	-	-	HYPH
cord-006229-7yoilsho	5782	11	lapse	lapse	NN
cord-006229-7yoilsho	5782	12	intravital	intravital	NNP
cord-006229-7yoilsho	5782	13	videomicroscopy	videomicroscopy	NNP
cord-006229-7yoilsho	5782	14	at	at	IN
cord-006229-7yoilsho	5782	15	discrete	discrete	JJ
cord-006229-7yoilsho	5782	16	time	time	NN
cord-006229-7yoilsho	5782	17	points	point	NNS
cord-006229-7yoilsho	5782	18	for	for	IN
cord-006229-7yoilsho	5782	19	up	up	IN
cord-006229-7yoilsho	5782	20	to	to	TO
cord-006229-7yoilsho	5782	21	48	48	CD
cord-006229-7yoilsho	5782	22	hours	hour	NNS
cord-006229-7yoilsho	5782	23	.	.	.
cord-006229-7yoilsho	5783	1	To	to	TO
cord-006229-7yoilsho	5783	2	improve	improve	VB
cord-006229-7yoilsho	5783	3	the	the	DT
cord-006229-7yoilsho	5783	4	visibility	visibility	NN
cord-006229-7yoilsho	5783	5	of	of	IN
cord-006229-7yoilsho	5783	6	the	the	DT
cord-006229-7yoilsho	5783	7	capillary	capillary	JJ
cord-006229-7yoilsho	5783	8	mesh	mesh	NN
cord-006229-7yoilsho	5783	9	,	,	,
cord-006229-7yoilsho	5783	10	videorecordings	videorecording	NNS
cord-006229-7yoilsho	5783	11	were	be	VBD
cord-006229-7yoilsho	5783	12	processed	process	VBN
cord-006229-7yoilsho	5783	13	offline	offline	RB
cord-006229-7yoilsho	5783	14	by	by	IN
cord-006229-7yoilsho	5783	15	generating	generate	VBG
cord-006229-7yoilsho	5783	16	coefficient	coefficient	NN
cord-006229-7yoilsho	5783	17	of	of	IN
cord-006229-7yoilsho	5783	18	variation	variation	NN
cord-006229-7yoilsho	5783	19	images	image	NNS
cord-006229-7yoilsho	5783	20	of	of	IN
cord-006229-7yoilsho	5783	21	pixel	pixel	JJ
cord-006229-7yoilsho	5783	22	grey	grey	JJ
cord-006229-7yoilsho	5783	23	values	value	NNS
cord-006229-7yoilsho	5783	24	over	over	IN
cord-006229-7yoilsho	5783	25	time	time	NN
cord-006229-7yoilsho	5783	26	.	.	.
cord-006229-7yoilsho	5784	1	Changes	change	NNS
cord-006229-7yoilsho	5784	2	of	of	IN
cord-006229-7yoilsho	5784	3	network	network	NN
cord-006229-7yoilsho	5784	4	topology	topology	NN
cord-006229-7yoilsho	5784	5	during	during	IN
cord-006229-7yoilsho	5784	6	the	the	DT
cord-006229-7yoilsho	5784	7	observation	observation	NN
cord-006229-7yoilsho	5784	8	time	time	NN
cord-006229-7yoilsho	5784	9	were	be	VBD
cord-006229-7yoilsho	5784	10	investigated	investigate	VBN
cord-006229-7yoilsho	5784	11	.	.	.
cord-006229-7yoilsho	5785	1	Results	result	NNS
cord-006229-7yoilsho	5785	2	:	:	:
cord-006229-7yoilsho	5786	1	In	in	IN
cord-006229-7yoilsho	5786	2	the	the	DT
cord-006229-7yoilsho	5786	3	CAM	cam	NN
cord-006229-7yoilsho	5786	4	,	,	,
cord-006229-7yoilsho	5786	5	a	a	DT
cord-006229-7yoilsho	5786	6	sequence	sequence	NN
cord-006229-7yoilsho	5786	7	of	of	IN
cord-006229-7yoilsho	5786	8	specific	specific	JJ
cord-006229-7yoilsho	5786	9	events	event	NNS
cord-006229-7yoilsho	5786	10	leading	lead	VBG
cord-006229-7yoilsho	5786	11	to	to	IN
cord-006229-7yoilsho	5786	12	extension	extension	NN
cord-006229-7yoilsho	5786	13	of	of	IN
cord-006229-7yoilsho	5786	14	existing	exist	VBG
cord-006229-7yoilsho	5786	15	vessel	vessel	NN
cord-006229-7yoilsho	5786	16	trees	tree	NNS
cord-006229-7yoilsho	5786	17	was	be	VBD
cord-006229-7yoilsho	5786	18	observed	observe	VBN
cord-006229-7yoilsho	5787	1	:	:	:
cord-006229-7yoilsho	5787	2	In	in	IN
cord-006229-7yoilsho	5787	3	a	a	DT
cord-006229-7yoilsho	5787	4	capillary	capillary	JJ
cord-006229-7yoilsho	5787	5	mesh	mesh	NN
cord-006229-7yoilsho	5787	6	region	region	NN
cord-006229-7yoilsho	5787	7	near	near	IN
cord-006229-7yoilsho	5787	8	terminal	terminal	JJ
cord-006229-7yoilsho	5787	9	branches	branch	NNS
cord-006229-7yoilsho	5787	10	of	of	IN
cord-006229-7yoilsho	5787	11	existing	exist	VBG
cord-006229-7yoilsho	5787	12	vessel	vessel	NN
cord-006229-7yoilsho	5787	13	trees	tree	NNS
cord-006229-7yoilsho	5787	14	,	,	,
cord-006229-7yoilsho	5787	15	homogeneous	homogeneous	JJ
cord-006229-7yoilsho	5787	16	flow	flow	NN
cord-006229-7yoilsho	5787	17	distribution	distribution	NN
cord-006229-7yoilsho	5787	18	is	be	VBZ
cord-006229-7yoilsho	5787	19	transferred	transfer	VBN
cord-006229-7yoilsho	5787	20	to	to	IN
cord-006229-7yoilsho	5787	21	inhomogeneous	inhomogeneous	JJ
cord-006229-7yoilsho	5787	22	flow	flow	NN
cord-006229-7yoilsho	5787	23	distribution	distribution	NN
cord-006229-7yoilsho	5787	24	:	:	:
cord-006229-7yoilsho	5787	25	Preferred	preferred	JJ
cord-006229-7yoilsho	5787	26	flow	flow	NN
cord-006229-7yoilsho	5787	27	pathways	pathway	NNS
cord-006229-7yoilsho	5787	28	through	through	IN
cord-006229-7yoilsho	5787	29	the	the	DT
cord-006229-7yoilsho	5787	30	mesh	mesh	NN
cord-006229-7yoilsho	5787	31	evolve	evolve	VBP
cord-006229-7yoilsho	5787	32	carrying	carry	VBG
cord-006229-7yoilsho	5787	33	most	most	JJS
cord-006229-7yoilsho	5787	34	of	of	IN
cord-006229-7yoilsho	5787	35	the	the	DT
cord-006229-7yoilsho	5787	36	blood	blood	NN
cord-006229-7yoilsho	5787	37	.	.	.
cord-006229-7yoilsho	5788	1	Over	over	IN
cord-006229-7yoilsho	5788	2	time	time	NN
cord-006229-7yoilsho	5788	3	,	,	,
cord-006229-7yoilsho	5788	4	these	these	DT
cord-006229-7yoilsho	5788	5	flow	flow	NN
cord-006229-7yoilsho	5788	6	pathways	pathway	NNS
cord-006229-7yoilsho	5788	7	exhibit	exhibit	VBP
cord-006229-7yoilsho	5788	8	diameter	diameter	NN
cord-006229-7yoilsho	5788	9	increase	increase	NN
cord-006229-7yoilsho	5788	10	,	,	,
cord-006229-7yoilsho	5788	11	straighten	straighten	VB
cord-006229-7yoilsho	5788	12	and	and	CC
cord-006229-7yoilsho	5788	13	connect	connect	VB
cord-006229-7yoilsho	5788	14	the	the	DT
cord-006229-7yoilsho	5788	15	mesh	mesh	NN
cord-006229-7yoilsho	5788	16	to	to	IN
cord-006229-7yoilsho	5788	17	arteriolar	arteriolar	JJ
cord-006229-7yoilsho	5788	18	and	and	CC
cord-006229-7yoilsho	5788	19	venular	venular	JJ
cord-006229-7yoilsho	5788	20	trees	tree	NNS
cord-006229-7yoilsho	5788	21	.	.	.
cord-006229-7yoilsho	5789	1	In	in	IN
cord-006229-7yoilsho	5789	2	contrast	contrast	NN
cord-006229-7yoilsho	5789	3	,	,	,
cord-006229-7yoilsho	5789	4	less	less	RBR
cord-006229-7yoilsho	5789	5	perfused	perfuse	VBN
cord-006229-7yoilsho	5789	6	parallel	parallel	NN
cord-006229-7yoilsho	5789	7	mesh	mesh	NN
cord-006229-7yoilsho	5789	8	flow	flow	NN
cord-006229-7yoilsho	5789	9	pathways	pathway	NNS
cord-006229-7yoilsho	5789	10	and	and	CC
cord-006229-7yoilsho	5789	11	transversal	transversal	JJ
cord-006229-7yoilsho	5789	12	mesh	mesh	NN
cord-006229-7yoilsho	5789	13	segments	segment	NNS
cord-006229-7yoilsho	5789	14	exhibit	exhibit	VBP
cord-006229-7yoilsho	5789	15	progressive	progressive	JJ
cord-006229-7yoilsho	5789	16	decrease	decrease	NN
cord-006229-7yoilsho	5789	17	of	of	IN
cord-006229-7yoilsho	5789	18	flow	flow	NN
cord-006229-7yoilsho	5789	19	and	and	CC
cord-006229-7yoilsho	5789	20	diameter	diameter	NN
cord-006229-7yoilsho	5789	21	resulting	result	VBG
cord-006229-7yoilsho	5789	22	in	in	IN
cord-006229-7yoilsho	5789	23	vessel	vessel	NN
cord-006229-7yoilsho	5789	24	regression	regression	NN
cord-006229-7yoilsho	5789	25	.	.	.
cord-006229-7yoilsho	5790	1	As	as	IN
cord-006229-7yoilsho	5790	2	a	a	DT
cord-006229-7yoilsho	5790	3	result	result	NN
cord-006229-7yoilsho	5790	4	,	,	,
cord-006229-7yoilsho	5790	5	hierarchical	hierarchical	JJ
cord-006229-7yoilsho	5790	6	vessel	vessel	NN
cord-006229-7yoilsho	5790	7	tree	tree	NN
cord-006229-7yoilsho	5790	8	structures	structure	NNS
cord-006229-7yoilsho	5790	9	are	be	VBP
cord-006229-7yoilsho	5790	10	extended	extend	VBN
cord-006229-7yoilsho	5790	11	into	into	IN
cord-006229-7yoilsho	5790	12	the	the	DT
cord-006229-7yoilsho	5790	13	mesh	mesh	NN
cord-006229-7yoilsho	5790	14	region	region	NN
cord-006229-7yoilsho	5790	15	.	.	.
cord-006229-7yoilsho	5791	1	While	while	IN
cord-006229-7yoilsho	5791	2	newly	newly	RB
cord-006229-7yoilsho	5791	3	generated	generate	VBN
cord-006229-7yoilsho	5791	4	tree	tree	NN
cord-006229-7yoilsho	5791	5	extensions	extension	NNS
cord-006229-7yoilsho	5791	6	are	be	VBP
cord-006229-7yoilsho	5791	7	located	locate	VBN
cord-006229-7yoilsho	5791	8	above	above	IN
cord-006229-7yoilsho	5791	9	the	the	DT
cord-006229-7yoilsho	5791	10	mesh	mesh	NN
cord-006229-7yoilsho	5791	11	at	at	IN
cord-006229-7yoilsho	5791	12	the	the	DT
cord-006229-7yoilsho	5791	13	beginning	beginning	NN
cord-006229-7yoilsho	5791	14	,	,	,
cord-006229-7yoilsho	5791	15	they	-PRON-	PRP
cord-006229-7yoilsho	5791	16	sink	sink	VBP
cord-006229-7yoilsho	5791	17	to	to	IN
cord-006229-7yoilsho	5791	18	a	a	DT
cord-006229-7yoilsho	5791	19	lower	low	JJR
cord-006229-7yoilsho	5791	20	level	level	NN
cord-006229-7yoilsho	5791	21	at	at	IN
cord-006229-7yoilsho	5791	22	later	later	JJ
cord-006229-7yoilsho	5791	23	stages	stage	NNS
cord-006229-7yoilsho	5791	24	until	until	IN
cord-006229-7yoilsho	5791	25	they	-PRON-	PRP
cord-006229-7yoilsho	5791	26	are	be	VBP
cord-006229-7yoilsho	5791	27	finally	finally	RB
cord-006229-7yoilsho	5791	28	covered	cover	VBN
cord-006229-7yoilsho	5791	29	by	by	IN
cord-006229-7yoilsho	5791	30	a	a	DT
cord-006229-7yoilsho	5791	31	reconstituted	reconstitute	VBN
cord-006229-7yoilsho	5791	32	mesh	mesh	NN
cord-006229-7yoilsho	5791	33	network	network	NN
cord-006229-7yoilsho	5791	34	.	.	.
cord-006229-7yoilsho	5792	1	The	the	DT
cord-006229-7yoilsho	5792	2	CAM	CAM	NNP
cord-006229-7yoilsho	5792	3	ex	ex	FW
cord-006229-7yoilsho	5792	4	ovo	ovo	NN
cord-006229-7yoilsho	5792	5	model	model	NN
cord-006229-7yoilsho	5792	6	is	be	VBZ
cord-006229-7yoilsho	5792	7	well	well	RB
cord-006229-7yoilsho	5792	8	suited	suited	JJ
cord-006229-7yoilsho	5792	9	for	for	IN
cord-006229-7yoilsho	5792	10	studying	study	VBG
cord-006229-7yoilsho	5792	11	emerging	emerge	VBG
cord-006229-7yoilsho	5792	12	angiogenesis	angiogenesis	NN
cord-006229-7yoilsho	5792	13	.	.	.
cord-006229-7yoilsho	5793	1	Vessel	vessel	NN
cord-006229-7yoilsho	5793	2	tree	tree	NN
cord-006229-7yoilsho	5793	3	extension	extension	NN
cord-006229-7yoilsho	5793	4	occurs	occur	VBZ
cord-006229-7yoilsho	5793	5	via	via	IN
cord-006229-7yoilsho	5793	6	parallel	parallel	JJ
cord-006229-7yoilsho	5793	7	processes	process	NNS
cord-006229-7yoilsho	5793	8	of	of	IN
cord-006229-7yoilsho	5793	9	vessel	vessel	NN
cord-006229-7yoilsho	5793	10	maturation	maturation	NN
cord-006229-7yoilsho	5793	11	and	and	CC
cord-006229-7yoilsho	5793	12	capillary	capillary	JJ
cord-006229-7yoilsho	5793	13	mesh	mesh	NN
cord-006229-7yoilsho	5793	14	segment	segment	NN
cord-006229-7yoilsho	5793	15	regression	regression	NN
cord-006229-7yoilsho	5793	16	.	.	.
cord-006229-7yoilsho	5794	1	At	at	IN
cord-006229-7yoilsho	5794	2	later	later	JJ
cord-006229-7yoilsho	5794	3	stages	stage	NNS
cord-006229-7yoilsho	5794	4	,	,	,
cord-006229-7yoilsho	5794	5	newly	newly	RB
cord-006229-7yoilsho	5794	6	formed	form	VBN
cord-006229-7yoilsho	5794	7	vessel	vessel	NN
cord-006229-7yoilsho	5794	8	tree	tree	NN
cord-006229-7yoilsho	5794	9	branches	branch	NNS
cord-006229-7yoilsho	5794	10	sink	sink	VBP
cord-006229-7yoilsho	5794	11	and	and	CC
cord-006229-7yoilsho	5794	12	the	the	DT
cord-006229-7yoilsho	5794	13	capillary	capillary	JJ
cord-006229-7yoilsho	5794	14	mesh	mesh	NN
cord-006229-7yoilsho	5794	15	is	be	VBZ
cord-006229-7yoilsho	5794	16	reconstituted	reconstitute	VBN
cord-006229-7yoilsho	5794	17	above	above	RB
cord-006229-7yoilsho	5794	18	.	.	.
cord-006229-7yoilsho	5795	1	In	in	IN
cord-006229-7yoilsho	5795	2	the	the	DT
cord-006229-7yoilsho	5795	3	next	next	JJ
cord-006229-7yoilsho	5795	4	step	step	NN
cord-006229-7yoilsho	5795	5	of	of	IN
cord-006229-7yoilsho	5795	6	our	-PRON-	PRP$
cord-006229-7yoilsho	5795	7	project	project	NN
cord-006229-7yoilsho	5795	8	,	,	,
cord-006229-7yoilsho	5795	9	we	-PRON-	PRP
cord-006229-7yoilsho	5795	10	will	will	MD
cord-006229-7yoilsho	5795	11	implement	implement	VB
cord-006229-7yoilsho	5795	12	these	these	DT
cord-006229-7yoilsho	5795	13	phenomena	phenomenon	NNS
cord-006229-7yoilsho	5795	14	in	in	IN
cord-006229-7yoilsho	5795	15	a	a	DT
cord-006229-7yoilsho	5795	16	computer	computer	NN
cord-006229-7yoilsho	5795	17	simulation	simulation	NN
cord-006229-7yoilsho	5795	18	and	and	CC
cord-006229-7yoilsho	5795	19	use	use	VB
cord-006229-7yoilsho	5795	20	theoretical	theoretical	JJ
cord-006229-7yoilsho	5795	21	modeling	modeling	NN
cord-006229-7yoilsho	5795	22	to	to	TO
cord-006229-7yoilsho	5795	23	further	further	RB
cord-006229-7yoilsho	5795	24	investigate	investigate	VB
cord-006229-7yoilsho	5795	25	and	and	CC
cord-006229-7yoilsho	5795	26	better	well	RBR
cord-006229-7yoilsho	5795	27	understand	understand	VB
cord-006229-7yoilsho	5795	28	principles	principle	NNS
cord-006229-7yoilsho	5795	29	underlying	underlie	VBG
cord-006229-7yoilsho	5795	30	microvascular	microvascular	JJ
cord-006229-7yoilsho	5795	31	network	network	NN
cord-006229-7yoilsho	5795	32	maturation	maturation	NN
cord-006229-7yoilsho	5795	33	.	.	.
cord-006229-7yoilsho	5796	1	This	this	DT
cord-006229-7yoilsho	5796	2	will	will	MD
cord-006229-7yoilsho	5796	3	allow	allow	VB
cord-006229-7yoilsho	5796	4	us	-PRON-	PRP
cord-006229-7yoilsho	5796	5	to	to	TO
cord-006229-7yoilsho	5796	6	derive	derive	VB
cord-006229-7yoilsho	5796	7	effective	effective	JJ
cord-006229-7yoilsho	5796	8	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	5796	9	strategies	strategy	NNS
cord-006229-7yoilsho	5796	10	which	which	WDT
cord-006229-7yoilsho	5796	11	could	could	MD
cord-006229-7yoilsho	5796	12	be	be	VB
cord-006229-7yoilsho	5796	13	tested	test	VBN
cord-006229-7yoilsho	5796	14	in	in	IN
cord-006229-7yoilsho	5796	15	the	the	DT
cord-006229-7yoilsho	5796	16	CAM	CAM	NNP
cord-006229-7yoilsho	5796	17	model	model	NN
cord-006229-7yoilsho	5796	18	.	.	.
cord-006229-7yoilsho	5797	1	Chemicals	chemical	NNS
cord-006229-7yoilsho	5797	2	are	be	VBP
cord-006229-7yoilsho	5797	3	able	able	JJ
cord-006229-7yoilsho	5797	4	to	to	TO
cord-006229-7yoilsho	5797	5	induce	induce	VB
cord-006229-7yoilsho	5797	6	cancer	cancer	NN
cord-006229-7yoilsho	5797	7	in	in	IN
cord-006229-7yoilsho	5797	8	a	a	DT
cord-006229-7yoilsho	5797	9	wide	wide	JJ
cord-006229-7yoilsho	5797	10	range	range	NN
cord-006229-7yoilsho	5797	11	of	of	IN
cord-006229-7yoilsho	5797	12	organs	organ	NNS
cord-006229-7yoilsho	5797	13	.	.	.
cord-006229-7yoilsho	5798	1	Therefore	therefore	RB
cord-006229-7yoilsho	5798	2	,	,	,
cord-006229-7yoilsho	5798	3	it	-PRON-	PRP
cord-006229-7yoilsho	5798	4	is	be	VBZ
cord-006229-7yoilsho	5798	5	very	very	RB
cord-006229-7yoilsho	5798	6	important	important	JJ
cord-006229-7yoilsho	5798	7	to	to	TO
cord-006229-7yoilsho	5798	8	investigate	investigate	VB
cord-006229-7yoilsho	5798	9	the	the	DT
cord-006229-7yoilsho	5798	10	toxic	toxic	JJ
cord-006229-7yoilsho	5798	11	properties	property	NNS
cord-006229-7yoilsho	5798	12	of	of	IN
cord-006229-7yoilsho	5798	13	chemical	chemical	JJ
cord-006229-7yoilsho	5798	14	substances	substance	NNS
cord-006229-7yoilsho	5798	15	,	,	,
cord-006229-7yoilsho	5798	16	especially	especially	RB
cord-006229-7yoilsho	5798	17	their	-PRON-	PRP$
cord-006229-7yoilsho	5798	18	carcinogenic	carcinogenic	JJ
cord-006229-7yoilsho	5798	19	potential	potential	NN
cord-006229-7yoilsho	5798	20	.	.	.
cord-006229-7yoilsho	5799	1	In	in	IN
cord-006229-7yoilsho	5799	2	this	this	DT
cord-006229-7yoilsho	5799	3	context	context	NN
cord-006229-7yoilsho	5799	4	the	the	DT
cord-006229-7yoilsho	5799	5	number	number	NN
cord-006229-7yoilsho	5799	6	of	of	IN
cord-006229-7yoilsho	5799	7	animal	animal	NN
cord-006229-7yoilsho	5799	8	experiments	experiment	NNS
cord-006229-7yoilsho	5799	9	will	will	MD
cord-006229-7yoilsho	5799	10	drastically	drastically	RB
cord-006229-7yoilsho	5799	11	increase	increase	VB
cord-006229-7yoilsho	5799	12	in	in	IN
cord-006229-7yoilsho	5799	13	the	the	DT
cord-006229-7yoilsho	5799	14	future	future	NN
cord-006229-7yoilsho	5799	15	.	.	.
cord-006229-7yoilsho	5800	1	In	in	IN
cord-006229-7yoilsho	5800	2	order	order	NN
cord-006229-7yoilsho	5800	3	to	to	TO
cord-006229-7yoilsho	5800	4	avoid	avoid	VB
cord-006229-7yoilsho	5800	5	the	the	DT
cord-006229-7yoilsho	5800	6	use	use	NN
cord-006229-7yoilsho	5800	7	of	of	IN
cord-006229-7yoilsho	5800	8	expensive	expensive	JJ
cord-006229-7yoilsho	5800	9	and	and	CC
cord-006229-7yoilsho	5800	10	time	time	NN
cord-006229-7yoilsho	5800	11	consuming	consume	VBG
cord-006229-7yoilsho	5800	12	animal	animal	NN
cord-006229-7yoilsho	5800	13	experiments	experiment	NNS
cord-006229-7yoilsho	5800	14	for	for	IN
cord-006229-7yoilsho	5800	15	long	long	JJ
cord-006229-7yoilsho	5800	16	-	-	HYPH
cord-006229-7yoilsho	5800	17	term	term	NN
cord-006229-7yoilsho	5800	18	carcinogenic	carcinogenic	JJ
cord-006229-7yoilsho	5800	19	studies	study	NNS
cord-006229-7yoilsho	5800	20	,	,	,
cord-006229-7yoilsho	5800	21	the	the	DT
cord-006229-7yoilsho	5800	22	development	development	NN
cord-006229-7yoilsho	5800	23	of	of	IN
cord-006229-7yoilsho	5800	24	an	an	DT
cord-006229-7yoilsho	5800	25	in	in	FW
cord-006229-7yoilsho	5800	26	vitro	vitro	FW
cord-006229-7yoilsho	5800	27	system	system	NN
cord-006229-7yoilsho	5800	28	to	to	TO
cord-006229-7yoilsho	5800	29	test	test	VB
cord-006229-7yoilsho	5800	30	the	the	DT
cord-006229-7yoilsho	5800	31	carcinogenic	carcinogenic	JJ
cord-006229-7yoilsho	5800	32	potential	potential	NN
cord-006229-7yoilsho	5800	33	of	of	IN
cord-006229-7yoilsho	5800	34	a	a	DT
cord-006229-7yoilsho	5800	35	high	high	JJ
cord-006229-7yoilsho	5800	36	number	number	NN
cord-006229-7yoilsho	5800	37	of	of	IN
cord-006229-7yoilsho	5800	38	chemicals	chemical	NNS
cord-006229-7yoilsho	5800	39	in	in	IN
cord-006229-7yoilsho	5800	40	a	a	DT
cord-006229-7yoilsho	5800	41	highly	highly	RB
cord-006229-7yoilsho	5800	42	reproducible	reproducible	JJ
cord-006229-7yoilsho	5800	43	manner	manner	NN
cord-006229-7yoilsho	5800	44	within	within	IN
cord-006229-7yoilsho	5800	45	a	a	DT
cord-006229-7yoilsho	5800	46	short	short	JJ
cord-006229-7yoilsho	5800	47	period	period	NN
cord-006229-7yoilsho	5800	48	of	of	IN
cord-006229-7yoilsho	5800	49	time	time	NN
cord-006229-7yoilsho	5800	50	is	be	VBZ
cord-006229-7yoilsho	5800	51	imperative	imperative	JJ
cord-006229-7yoilsho	5800	52	.	.	.
cord-006229-7yoilsho	5801	1	By	by	IN
cord-006229-7yoilsho	5801	2	combination	combination	NN
cord-006229-7yoilsho	5801	3	of	of	IN
cord-006229-7yoilsho	5801	4	the	the	DT
cord-006229-7yoilsho	5801	5	well	well	RB
cord-006229-7yoilsho	5801	6	-	-	HYPH
cord-006229-7yoilsho	5801	7	established	establish	VBN
cord-006229-7yoilsho	5801	8	BALB	BALB	NNP
cord-006229-7yoilsho	5801	9	/	/	SYM
cord-006229-7yoilsho	5801	10	c	c	NN
cord-006229-7yoilsho	5801	11	cell	cell	NN
cord-006229-7yoilsho	5801	12	transformation	transformation	NN
cord-006229-7yoilsho	5801	13	method	method	NN
cord-006229-7yoilsho	5801	14	with	with	IN
cord-006229-7yoilsho	5801	15	the	the	DT
cord-006229-7yoilsho	5801	16	soft	soft	JJ
cord-006229-7yoilsho	5801	17	agar	agar	NNP
cord-006229-7yoilsho	5801	18	colony	colony	NN
cord-006229-7yoilsho	5801	19	formation	formation	NN
cord-006229-7yoilsho	5801	20	assay	assay	NN
cord-006229-7yoilsho	5801	21	,	,	,
cord-006229-7yoilsho	5801	22	we	-PRON-	PRP
cord-006229-7yoilsho	5801	23	developed	develop	VBD
cord-006229-7yoilsho	5801	24	a	a	DT
cord-006229-7yoilsho	5801	25	high	high	JJ
cord-006229-7yoilsho	5801	26	-	-	HYPH
cord-006229-7yoilsho	5801	27	throughput	throughput	NN
cord-006229-7yoilsho	5801	28	in	in	IN
cord-006229-7yoilsho	5801	29	vitro	vitro	FW
cord-006229-7yoilsho	5801	30	system	system	NN
cord-006229-7yoilsho	5801	31	to	to	TO
cord-006229-7yoilsho	5801	32	identify	identify	VB
cord-006229-7yoilsho	5801	33	effects	effect	NNS
cord-006229-7yoilsho	5801	34	of	of	IN
cord-006229-7yoilsho	5801	35	chemicals	chemical	NNS
cord-006229-7yoilsho	5801	36	on	on	IN
cord-006229-7yoilsho	5801	37	cell	cell	NN
cord-006229-7yoilsho	5801	38	transformation	transformation	NN
cord-006229-7yoilsho	5801	39	for	for	IN
cord-006229-7yoilsho	5801	40	the	the	DT
cord-006229-7yoilsho	5801	41	first	first	JJ
cord-006229-7yoilsho	5801	42	time	time	NN
cord-006229-7yoilsho	5801	43	.	.	.
cord-006229-7yoilsho	5802	1	BALB	BALB	NNP
cord-006229-7yoilsho	5802	2	/	/	SYM
cord-006229-7yoilsho	5802	3	c	c	NN
cord-006229-7yoilsho	5802	4	mouse	mouse	NN
cord-006229-7yoilsho	5802	5	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	5802	6	are	be	VBP
cord-006229-7yoilsho	5802	7	treated	treat	VBN
cord-006229-7yoilsho	5802	8	with	with	IN
cord-006229-7yoilsho	5802	9	3-Methylcholanthrene	3-methylcholanthrene	CD
cord-006229-7yoilsho	5802	10	as	as	IN
cord-006229-7yoilsho	5802	11	a	a	DT
cord-006229-7yoilsho	5802	12	tumour	tumour	NN
cord-006229-7yoilsho	5802	13	initiator	initiator	NN
cord-006229-7yoilsho	5802	14	and	and	CC
cord-006229-7yoilsho	5802	15	12-O	12-o	CD
cord-006229-7yoilsho	5802	16	-	-	HYPH
cord-006229-7yoilsho	5802	17	Tetradecanoylphorbol-13-acetate	tetradecanoylphorbol-13-acetate	NN
cord-006229-7yoilsho	5802	18	as	as	IN
cord-006229-7yoilsho	5802	19	promotor	promotor	NN
cord-006229-7yoilsho	5802	20	for	for	IN
cord-006229-7yoilsho	5802	21	several	several	JJ
cord-006229-7yoilsho	5802	22	days	day	NNS
cord-006229-7yoilsho	5802	23	,	,	,
cord-006229-7yoilsho	5802	24	whereby	whereby	WRB
cord-006229-7yoilsho	5802	25	foci	foci	NN
cord-006229-7yoilsho	5802	26	of	of	IN
cord-006229-7yoilsho	5802	27	transformed	transform	VBN
cord-006229-7yoilsho	5802	28	cells	cell	NNS
cord-006229-7yoilsho	5802	29	are	be	VBP
cord-006229-7yoilsho	5802	30	developed	develop	VBN
cord-006229-7yoilsho	5802	31	.	.	.
cord-006229-7yoilsho	5803	1	After	after	IN
cord-006229-7yoilsho	5803	2	the	the	DT
cord-006229-7yoilsho	5803	3	promotion	promotion	NN
cord-006229-7yoilsho	5803	4	phase	phase	NN
cord-006229-7yoilsho	5803	5	of	of	IN
cord-006229-7yoilsho	5803	6	the	the	DT
cord-006229-7yoilsho	5803	7	common	common	JJ
cord-006229-7yoilsho	5803	8	BALB	BALB	NNP
cord-006229-7yoilsho	5803	9	/	/	SYM
cord-006229-7yoilsho	5803	10	c	c	NN
cord-006229-7yoilsho	5803	11	cell	cell	NN
cord-006229-7yoilsho	5803	12	transformation	transformation	NN
cord-006229-7yoilsho	5803	13	assay	assay	NN
cord-006229-7yoilsho	5803	14	,	,	,
cord-006229-7yoilsho	5803	15	cells	cell	NNS
cord-006229-7yoilsho	5803	16	are	be	VBP
cord-006229-7yoilsho	5803	17	transferred	transfer	VBN
cord-006229-7yoilsho	5803	18	into	into	IN
cord-006229-7yoilsho	5803	19	soft	soft	JJ
cord-006229-7yoilsho	5803	20	agar	agar	NN
cord-006229-7yoilsho	5803	21	to	to	TO
cord-006229-7yoilsho	5803	22	further	further	RB
cord-006229-7yoilsho	5803	23	monitor	monitor	VB
cord-006229-7yoilsho	5803	24	the	the	DT
cord-006229-7yoilsho	5803	25	anchorage	anchorage	NNP
cord-006229-7yoilsho	5803	26	independent	independent	JJ
cord-006229-7yoilsho	5803	27	growth	growth	NN
cord-006229-7yoilsho	5803	28	of	of	IN
cord-006229-7yoilsho	5803	29	transformed	transform	VBN
cord-006229-7yoilsho	5803	30	cells	cell	NNS
cord-006229-7yoilsho	5803	31	only	only	RB
cord-006229-7yoilsho	5803	32	.	.	.
cord-006229-7yoilsho	5804	1	The	the	DT
cord-006229-7yoilsho	5804	2	established	establish	VBN
cord-006229-7yoilsho	5804	3	soft	soft	JJ
cord-006229-7yoilsho	5804	4	agar	agar	NN
cord-006229-7yoilsho	5804	5	transformation	transformation	NN
cord-006229-7yoilsho	5804	6	assay	assay	NN
cord-006229-7yoilsho	5804	7	reproduces	reproduce	VBZ
cord-006229-7yoilsho	5804	8	the	the	DT
cord-006229-7yoilsho	5804	9	foci	foci	JJ
cord-006229-7yoilsho	5804	10	growth	growth	NN
cord-006229-7yoilsho	5804	11	of	of	IN
cord-006229-7yoilsho	5804	12	previous	previous	JJ
cord-006229-7yoilsho	5804	13	experiments	experiment	NNS
cord-006229-7yoilsho	5804	14	and	and	CC
cord-006229-7yoilsho	5804	15	is	be	VBZ
cord-006229-7yoilsho	5804	16	performed	perform	VBN
cord-006229-7yoilsho	5804	17	in	in	IN
cord-006229-7yoilsho	5804	18	96-well	96-well	CD
cord-006229-7yoilsho	5804	19	plate	plate	NN
cord-006229-7yoilsho	5804	20	format	format	NN
cord-006229-7yoilsho	5804	21	.	.	.
cord-006229-7yoilsho	5805	1	Hence	hence	RB
cord-006229-7yoilsho	5805	2	,	,	,
cord-006229-7yoilsho	5805	3	we	-PRON-	PRP
cord-006229-7yoilsho	5805	4	can	can	MD
cord-006229-7yoilsho	5805	5	analyse	analyse	VB
cord-006229-7yoilsho	5805	6	the	the	DT
cord-006229-7yoilsho	5805	7	carcinogenic	carcinogenic	JJ
cord-006229-7yoilsho	5805	8	potential	potential	NN
cord-006229-7yoilsho	5805	9	of	of	IN
cord-006229-7yoilsho	5805	10	several	several	JJ
cord-006229-7yoilsho	5805	11	chemical	chemical	JJ
cord-006229-7yoilsho	5805	12	substances	substance	NNS
cord-006229-7yoilsho	5805	13	in	in	IN
cord-006229-7yoilsho	5805	14	parallel	parallel	NN
cord-006229-7yoilsho	5805	15	and	and	CC
cord-006229-7yoilsho	5805	16	are	be	VBP
cord-006229-7yoilsho	5805	17	also	also	RB
cord-006229-7yoilsho	5805	18	searching	search	VBG
cord-006229-7yoilsho	5805	19	for	for	IN
cord-006229-7yoilsho	5805	20	alternative	alternative	JJ
cord-006229-7yoilsho	5805	21	endpoint	endpoint	NN
cord-006229-7yoilsho	5805	22	analysis	analysis	NN
cord-006229-7yoilsho	5805	23	,	,	,
cord-006229-7yoilsho	5805	24	e.g.	e.g.	IN
cord-006229-7yoilsho	5805	25	the	the	DT
cord-006229-7yoilsho	5805	26	usage	usage	NN
cord-006229-7yoilsho	5805	27	of	of	IN
cord-006229-7yoilsho	5805	28	fluorescing	fluoresce	VBG
cord-006229-7yoilsho	5805	29	cells	cell	NNS
cord-006229-7yoilsho	5805	30	stably	stably	RB
cord-006229-7yoilsho	5805	31	expressing	express	VBG
cord-006229-7yoilsho	5805	32	iRFP	irfp	CD
cord-006229-7yoilsho	5805	33	,	,	,
cord-006229-7yoilsho	5805	34	instead	instead	RB
cord-006229-7yoilsho	5805	35	of	of	IN
cord-006229-7yoilsho	5805	36	the	the	DT
cord-006229-7yoilsho	5805	37	former	former	JJ
cord-006229-7yoilsho	5805	38	time	time	NN
cord-006229-7yoilsho	5805	39	-	-	HYPH
cord-006229-7yoilsho	5805	40	consuming	consume	VBG
cord-006229-7yoilsho	5805	41	microscopic	microscopic	JJ
cord-006229-7yoilsho	5805	42	assessment	assessment	NN
cord-006229-7yoilsho	5805	43	.	.	.
cord-006229-7yoilsho	5806	1	The	the	DT
cord-006229-7yoilsho	5806	2	here	here	RB
cord-006229-7yoilsho	5806	3	presented	present	VBN
cord-006229-7yoilsho	5806	4	new	new	JJ
cord-006229-7yoilsho	5806	5	technique	technique	NN
cord-006229-7yoilsho	5806	6	is	be	VBZ
cord-006229-7yoilsho	5806	7	a	a	DT
cord-006229-7yoilsho	5806	8	high	high	JJ
cord-006229-7yoilsho	5806	9	-	-	HYPH
cord-006229-7yoilsho	5806	10	throughput	throughput	NN
cord-006229-7yoilsho	5806	11	and	and	CC
cord-006229-7yoilsho	5806	12	low	low	RB
cord-006229-7yoilsho	5806	13	priced	price	VBN
cord-006229-7yoilsho	5806	14	alternative	alternative	NN
cord-006229-7yoilsho	5806	15	for	for	IN
cord-006229-7yoilsho	5806	16	the	the	DT
cord-006229-7yoilsho	5806	17	evaluation	evaluation	NN
cord-006229-7yoilsho	5806	18	of	of	IN
cord-006229-7yoilsho	5806	19	the	the	DT
cord-006229-7yoilsho	5806	20	carcinogenic	carcinogenic	JJ
cord-006229-7yoilsho	5806	21	potential	potential	NN
cord-006229-7yoilsho	5806	22	of	of	IN
cord-006229-7yoilsho	5806	23	chemical	chemical	JJ
cord-006229-7yoilsho	5806	24	substances	substance	NNS
cord-006229-7yoilsho	5806	25	in	in	IN
cord-006229-7yoilsho	5806	26	a	a	DT
cord-006229-7yoilsho	5806	27	short	short	JJ
cord-006229-7yoilsho	5806	28	period	period	NN
cord-006229-7yoilsho	5806	29	of	of	IN
cord-006229-7yoilsho	5806	30	time	time	NN
cord-006229-7yoilsho	5806	31	without	without	IN
cord-006229-7yoilsho	5806	32	animal	animal	NN
cord-006229-7yoilsho	5806	33	testing	testing	NN
cord-006229-7yoilsho	5806	34	.	.	.
cord-006229-7yoilsho	5807	1	The	the	DT
cord-006229-7yoilsho	5807	2	effort	effort	NN
cord-006229-7yoilsho	5807	3	to	to	TO
cord-006229-7yoilsho	5807	4	develop	develop	VB
cord-006229-7yoilsho	5807	5	new	new	JJ
cord-006229-7yoilsho	5807	6	or	or	CC
cord-006229-7yoilsho	5807	7	refine	refine	VB
cord-006229-7yoilsho	5807	8	established	establish	VBN
cord-006229-7yoilsho	5807	9	in	in	IN
cord-006229-7yoilsho	5807	10	vitro	vitro	FW
cord-006229-7yoilsho	5807	11	test	test	NN
cord-006229-7yoilsho	5807	12	systems	system	NNS
cord-006229-7yoilsho	5807	13	rises	rise	VBZ
cord-006229-7yoilsho	5807	14	due	due	IN
cord-006229-7yoilsho	5807	15	to	to	IN
cord-006229-7yoilsho	5807	16	animal	animal	NN
cord-006229-7yoilsho	5807	17	welfare	welfare	NN
cord-006229-7yoilsho	5807	18	,	,	,
cord-006229-7yoilsho	5807	19	scientific	scientific	JJ
cord-006229-7yoilsho	5807	20	and/or	and/or	CC
cord-006229-7yoilsho	5807	21	regulatory	regulatory	JJ
cord-006229-7yoilsho	5807	22	reasons	reason	NNS
cord-006229-7yoilsho	5807	23	(	(	-LRB-
cord-006229-7yoilsho	5807	24	e.g.	e.g.	RB
cord-006229-7yoilsho	5807	25	the	the	DT
cord-006229-7yoilsho	5807	26	animal	animal	NN
cord-006229-7yoilsho	5807	27	testing	testing	NN
cord-006229-7yoilsho	5807	28	ban	ban	NN
cord-006229-7yoilsho	5807	29	concerning	concern	VBG
cord-006229-7yoilsho	5807	30	the	the	DT
cord-006229-7yoilsho	5807	31	risk	risk	NN
cord-006229-7yoilsho	5807	32	assessment	assessment	NN
cord-006229-7yoilsho	5807	33	of	of	IN
cord-006229-7yoilsho	5807	34	cosmetic	cosmetic	JJ
cord-006229-7yoilsho	5807	35	product	product	NN
cord-006229-7yoilsho	5807	36	ingredients	ingredient	NNS
cord-006229-7yoilsho	5807	37	in	in	IN
cord-006229-7yoilsho	5807	38	March	March	NNP
cord-006229-7yoilsho	5807	39	2013	2013	CD
cord-006229-7yoilsho	5807	40	)	)	-RRB-
cord-006229-7yoilsho	5807	41	.	.	.
cord-006229-7yoilsho	5808	1	This	this	DT
cord-006229-7yoilsho	5808	2	progress	progress	NN
cord-006229-7yoilsho	5808	3	,	,	,
cord-006229-7yoilsho	5808	4	among	among	IN
cord-006229-7yoilsho	5808	5	others	other	NNS
cord-006229-7yoilsho	5808	6	,	,	,
cord-006229-7yoilsho	5808	7	leads	lead	VBZ
cord-006229-7yoilsho	5808	8	to	to	IN
cord-006229-7yoilsho	5808	9	an	an	DT
cord-006229-7yoilsho	5808	10	increased	increase	VBN
cord-006229-7yoilsho	5808	11	performance	performance	NN
cord-006229-7yoilsho	5808	12	of	of	IN
cord-006229-7yoilsho	5808	13	cell	cell	NN
cord-006229-7yoilsho	5808	14	-	-	HYPH
cord-006229-7yoilsho	5808	15	based	base	VBN
cord-006229-7yoilsho	5808	16	assays	assay	NNS
cord-006229-7yoilsho	5808	17	.	.	.
cord-006229-7yoilsho	5809	1	The	the	DT
cord-006229-7yoilsho	5809	2	majority	majority	NN
cord-006229-7yoilsho	5809	3	of	of	IN
cord-006229-7yoilsho	5809	4	model	model	NN
cord-006229-7yoilsho	5809	5	cell	cell	NN
cord-006229-7yoilsho	5809	6	lines	line	NNS
cord-006229-7yoilsho	5809	7	are	be	VBP
cord-006229-7yoilsho	5809	8	routinely	routinely	RB
cord-006229-7yoilsho	5809	9	cultured	culture	VBN
cord-006229-7yoilsho	5809	10	using	use	VBG
cord-006229-7yoilsho	5809	11	medium	medium	NN
cord-006229-7yoilsho	5809	12	supplemented	supplement	VBN
cord-006229-7yoilsho	5809	13	with	with	IN
cord-006229-7yoilsho	5809	14	fetal	fetal	JJ
cord-006229-7yoilsho	5809	15	bovine	bovine	JJ
cord-006229-7yoilsho	5809	16	serum	serum	NN
cord-006229-7yoilsho	5809	17	(	(	-LRB-
cord-006229-7yoilsho	5809	18	FBS	FBS	NNP
cord-006229-7yoilsho	5809	19	)	)	-RRB-
cord-006229-7yoilsho	5809	20	in	in	IN
cord-006229-7yoilsho	5809	21	amounts	amount	NNS
cord-006229-7yoilsho	5809	22	between	between	IN
cord-006229-7yoilsho	5809	23	5	5	CD
cord-006229-7yoilsho	5809	24	-	-	SYM
cord-006229-7yoilsho	5809	25	10	10	CD
cord-006229-7yoilsho	5809	26	%	%	NN
cord-006229-7yoilsho	5809	27	.	.	.
cord-006229-7yoilsho	5810	1	The	the	DT
cord-006229-7yoilsho	5810	2	application	application	NN
cord-006229-7yoilsho	5810	3	of	of	IN
cord-006229-7yoilsho	5810	4	serum	serum	NN
cord-006229-7yoilsho	5810	5	-	-	HYPH
cord-006229-7yoilsho	5810	6	substitutes	substitute	NNS
cord-006229-7yoilsho	5810	7	will	will	MD
cord-006229-7yoilsho	5810	8	provide	provide	VB
cord-006229-7yoilsho	5810	9	a	a	DT
cord-006229-7yoilsho	5810	10	reduction	reduction	NN
cord-006229-7yoilsho	5810	11	of	of	IN
cord-006229-7yoilsho	5810	12	the	the	DT
cord-006229-7yoilsho	5810	13	animal	animal	NN
cord-006229-7yoilsho	5810	14	number	number	NN
cord-006229-7yoilsho	5810	15	needed	need	VBN
cord-006229-7yoilsho	5810	16	,	,	,
cord-006229-7yoilsho	5810	17	which	which	WDT
cord-006229-7yoilsho	5810	18	corresponds	correspond	VBZ
cord-006229-7yoilsho	5810	19	to	to	IN
cord-006229-7yoilsho	5810	20	the	the	DT
cord-006229-7yoilsho	5810	21	guiding	guide	VBG
cord-006229-7yoilsho	5810	22	principles	principle	NNS
cord-006229-7yoilsho	5810	23	of	of	IN
cord-006229-7yoilsho	5810	24	the	the	DT
cord-006229-7yoilsho	5810	25	three	three	CD
cord-006229-7yoilsho	5810	26	R	r	NN
cord-006229-7yoilsho	5810	27	's	's	POS
cord-006229-7yoilsho	5810	28	(	(	-LRB-
cord-006229-7yoilsho	5810	29	3R	3R	NNP
cord-006229-7yoilsho	5810	30	)	)	-RRB-
cord-006229-7yoilsho	5810	31	,	,	,
cord-006229-7yoilsho	5810	32	described	describe	VBN
cord-006229-7yoilsho	5810	33	by	by	IN
cord-006229-7yoilsho	5810	34	Russel	Russel	NNP
cord-006229-7yoilsho	5810	35	and	and	CC
cord-006229-7yoilsho	5810	36	Burch	Burch	NNP
cord-006229-7yoilsho	5810	37	in	in	IN
cord-006229-7yoilsho	5810	38	1959	1959	CD
cord-006229-7yoilsho	5810	39	.	.	.
cord-006229-7yoilsho	5811	1	In	in	IN
cord-006229-7yoilsho	5811	2	addition	addition	NN
cord-006229-7yoilsho	5811	3	,	,	,
cord-006229-7yoilsho	5811	4	chemically	chemically	RB
cord-006229-7yoilsho	5811	5	defined	define	VBN
cord-006229-7yoilsho	5811	6	serum	serum	NN
cord-006229-7yoilsho	5811	7	-	-	HYPH
cord-006229-7yoilsho	5811	8	substitutes	substitute	NNS
cord-006229-7yoilsho	5811	9	have	have	VBP
cord-006229-7yoilsho	5811	10	the	the	DT
cord-006229-7yoilsho	5811	11	potential	potential	NN
cord-006229-7yoilsho	5811	12	to	to	TO
cord-006229-7yoilsho	5811	13	reduce	reduce	VB
cord-006229-7yoilsho	5811	14	the	the	DT
cord-006229-7yoilsho	5811	15	inter	inter	JJ
cord-006229-7yoilsho	5811	16	-	-	JJ
cord-006229-7yoilsho	5811	17	experimental	experimental	JJ
cord-006229-7yoilsho	5811	18	variability	variability	NN
cord-006229-7yoilsho	5811	19	of	of	IN
cord-006229-7yoilsho	5811	20	test	test	NN
cord-006229-7yoilsho	5811	21	conditions	condition	NNS
cord-006229-7yoilsho	5811	22	caused	cause	VBN
cord-006229-7yoilsho	5811	23	by	by	IN
cord-006229-7yoilsho	5811	24	the	the	DT
cord-006229-7yoilsho	5811	25	inherent	inherent	JJ
cord-006229-7yoilsho	5811	26	differences	difference	NNS
cord-006229-7yoilsho	5811	27	in	in	IN
cord-006229-7yoilsho	5811	28	chemical	chemical	JJ
cord-006229-7yoilsho	5811	29	composition	composition	NN
cord-006229-7yoilsho	5811	30	across	across	IN
cord-006229-7yoilsho	5811	31	FBS	FBS	NNP
cord-006229-7yoilsho	5811	32	batches	batch	NNS
cord-006229-7yoilsho	5811	33	1	1	CD
cord-006229-7yoilsho	5811	34	,	,	,
cord-006229-7yoilsho	5811	35	resulting	result	VBG
cord-006229-7yoilsho	5811	36	in	in	IN
cord-006229-7yoilsho	5811	37	a	a	DT
cord-006229-7yoilsho	5811	38	refinement	refinement	NN
cord-006229-7yoilsho	5811	39	of	of	IN
cord-006229-7yoilsho	5811	40	in	in	FW
cord-006229-7yoilsho	5811	41	vitro	vitro	FW
cord-006229-7yoilsho	5811	42	testing	testing	NN
cord-006229-7yoilsho	5811	43	.	.	.
cord-006229-7yoilsho	5812	1	In	in	IN
cord-006229-7yoilsho	5812	2	this	this	DT
cord-006229-7yoilsho	5812	3	study	study	NN
cord-006229-7yoilsho	5812	4	,	,	,
cord-006229-7yoilsho	5812	5	human	human	JJ
cord-006229-7yoilsho	5812	6	TK6	TK6	NNP
cord-006229-7yoilsho	5812	7	cells	cell	NNS
cord-006229-7yoilsho	5812	8	were	be	VBD
cord-006229-7yoilsho	5812	9	gradually	gradually	RB
cord-006229-7yoilsho	5812	10	adapted	adapt	VBN
cord-006229-7yoilsho	5812	11	to	to	IN
cord-006229-7yoilsho	5812	12	serum	serum	NN
cord-006229-7yoilsho	5812	13	-	-	HYPH
cord-006229-7yoilsho	5812	14	free	free	JJ
cord-006229-7yoilsho	5812	15	conditions	condition	NNS
cord-006229-7yoilsho	5812	16	,	,	,
cord-006229-7yoilsho	5812	17	where	where	WRB
cord-006229-7yoilsho	5812	18	they	-PRON-	PRP
cord-006229-7yoilsho	5812	19	show	show	VBP
cord-006229-7yoilsho	5812	20	comparable	comparable	JJ
cord-006229-7yoilsho	5812	21	growth	growth	NN
cord-006229-7yoilsho	5812	22	gradients	gradient	NNS
cord-006229-7yoilsho	5812	23	at	at	IN
cord-006229-7yoilsho	5812	24	the	the	DT
cord-006229-7yoilsho	5812	25	exponential	exponential	JJ
cord-006229-7yoilsho	5812	26	phase	phase	NN
cord-006229-7yoilsho	5812	27	.	.	.
cord-006229-7yoilsho	5813	1	For	for	IN
cord-006229-7yoilsho	5813	2	cells	cell	NNS
cord-006229-7yoilsho	5813	3	under	under	IN
cord-006229-7yoilsho	5813	4	serum	serum	NN
cord-006229-7yoilsho	5813	5	-	-	HYPH
cord-006229-7yoilsho	5813	6	free	free	JJ
cord-006229-7yoilsho	5813	7	conditions	condition	NNS
cord-006229-7yoilsho	5813	8	a	a	DT
cord-006229-7yoilsho	5813	9	mean	mean	NN
cord-006229-7yoilsho	5813	10	doubling	double	VBG
cord-006229-7yoilsho	5813	11	time	time	NN
cord-006229-7yoilsho	5813	12	of	of	IN
cord-006229-7yoilsho	5813	13	19.3	19.3	CD
cord-006229-7yoilsho	5814	1	(	(	-LRB-
cord-006229-7yoilsho	5814	2	±	±	NNP
cord-006229-7yoilsho	5814	3	1.7	1.7	CD
cord-006229-7yoilsho	5814	4	)	)	-RRB-
cord-006229-7yoilsho	5814	5	h	h	NNP
cord-006229-7yoilsho	5814	6	was	be	VBD
cord-006229-7yoilsho	5814	7	observed	observe	VBN
cord-006229-7yoilsho	5814	8	while	while	IN
cord-006229-7yoilsho	5814	9	FBS	FBS	NNP
cord-006229-7yoilsho	5814	10	supplemented	supplement	VBD
cord-006229-7yoilsho	5814	11	cells	cell	NNS
cord-006229-7yoilsho	5814	12	showed	show	VBD
cord-006229-7yoilsho	5814	13	a	a	DT
cord-006229-7yoilsho	5814	14	doubling	double	VBG
cord-006229-7yoilsho	5814	15	time	time	NN
cord-006229-7yoilsho	5814	16	of	of	IN
cord-006229-7yoilsho	5814	17	13.5	13.5	CD
cord-006229-7yoilsho	5814	18	(	(	-LRB-
cord-006229-7yoilsho	5814	19	±	±	NNP
cord-006229-7yoilsho	5814	20	0.8	0.8	CD
cord-006229-7yoilsho	5814	21	)	)	-RRB-
cord-006229-7yoilsho	5815	1	Several	several	JJ
cord-006229-7yoilsho	5815	2	non	non	JJ
cord-006229-7yoilsho	5815	3	-	-	JJ
cord-006229-7yoilsho	5815	4	animal	animal	JJ
cord-006229-7yoilsho	5815	5	test	test	NN
cord-006229-7yoilsho	5815	6	methods	method	NNS
cord-006229-7yoilsho	5815	7	addressing	address	VBG
cord-006229-7yoilsho	5815	8	key	key	JJ
cord-006229-7yoilsho	5815	9	events	event	NNS
cord-006229-7yoilsho	5815	10	in	in	IN
cord-006229-7yoilsho	5815	11	the	the	DT
cord-006229-7yoilsho	5815	12	sensitization	sensitization	NN
cord-006229-7yoilsho	5815	13	process	process	NN
cord-006229-7yoilsho	5815	14	have	have	VBP
cord-006229-7yoilsho	5815	15	passed	pass	VBN
cord-006229-7yoilsho	5815	16	formal	formal	JJ
cord-006229-7yoilsho	5815	17	validation	validation	NN
cord-006229-7yoilsho	5815	18	and	and	CC
cord-006229-7yoilsho	5815	19	OECD	OECD	NNP
cord-006229-7yoilsho	5815	20	(	(	-LRB-
cord-006229-7yoilsho	5815	21	draft	draft	NN
cord-006229-7yoilsho	5815	22	)	)	-RRB-
cord-006229-7yoilsho	5815	23	test	test	NN
cord-006229-7yoilsho	5815	24	guidelines	guideline	NNS
cord-006229-7yoilsho	5815	25	are	be	VBP
cord-006229-7yoilsho	5815	26	available	available	JJ
cord-006229-7yoilsho	5815	27	.	.	.
cord-006229-7yoilsho	5816	1	One	one	CD
cord-006229-7yoilsho	5816	2	of	of	IN
cord-006229-7yoilsho	5816	3	these	these	DT
cord-006229-7yoilsho	5816	4	methods	method	NNS
cord-006229-7yoilsho	5816	5	is	be	VBZ
cord-006229-7yoilsho	5816	6	the	the	DT
cord-006229-7yoilsho	5816	7	direct	direct	JJ
cord-006229-7yoilsho	5816	8	peptide	peptide	NN
cord-006229-7yoilsho	5816	9	reactivity	reactivity	NN
cord-006229-7yoilsho	5816	10	assay	assay	NN
cord-006229-7yoilsho	5816	11	(	(	-LRB-
cord-006229-7yoilsho	5816	12	DPRA	DPRA	NNP
cord-006229-7yoilsho	5816	13	)	)	-RRB-
cord-006229-7yoilsho	5816	14	assessing	assess	VBG
cord-006229-7yoilsho	5816	15	the	the	DT
cord-006229-7yoilsho	5816	16	ability	ability	NN
cord-006229-7yoilsho	5816	17	of	of	IN
cord-006229-7yoilsho	5816	18	a	a	DT
cord-006229-7yoilsho	5816	19	chemical	chemical	NN
cord-006229-7yoilsho	5816	20	to	to	TO
cord-006229-7yoilsho	5816	21	bind	bind	VB
cord-006229-7yoilsho	5816	22	to	to	IN
cord-006229-7yoilsho	5816	23	proteins	protein	NNS
cord-006229-7yoilsho	5816	24	to	to	TO
cord-006229-7yoilsho	5816	25	form	form	VB
cord-006229-7yoilsho	5816	26	a	a	DT
cord-006229-7yoilsho	5816	27	complete	complete	JJ
cord-006229-7yoilsho	5816	28	antigen	antigen	NN
cord-006229-7yoilsho	5816	29	(	(	-LRB-
cord-006229-7yoilsho	5816	30	OECD	OECD	NNP
cord-006229-7yoilsho	5816	31	TG	TG	NNP
cord-006229-7yoilsho	5816	32	442C	442C	NNP
cord-006229-7yoilsho	5816	33	)	)	-RRB-
cord-006229-7yoilsho	5816	34	.	.	.
cord-006229-7yoilsho	5817	1	The	the	DT
cord-006229-7yoilsho	5817	2	test	test	NN
cord-006229-7yoilsho	5817	3	is	be	VBZ
cord-006229-7yoilsho	5817	4	used	use	VBN
cord-006229-7yoilsho	5817	5	to	to	TO
cord-006229-7yoilsho	5817	6	obtain	obtain	VB
cord-006229-7yoilsho	5817	7	a	a	DT
cord-006229-7yoilsho	5817	8	yes	yes	UH
cord-006229-7yoilsho	5817	9	/	/	,
cord-006229-7yoilsho	5817	10	no	no	DT
cord-006229-7yoilsho	5817	11	answer	answer	NN
cord-006229-7yoilsho	5817	12	on	on	IN
cord-006229-7yoilsho	5817	13	whether	whether	IN
cord-006229-7yoilsho	5817	14	the	the	DT
cord-006229-7yoilsho	5817	15	substance	substance	NN
cord-006229-7yoilsho	5817	16	has	have	VBZ
cord-006229-7yoilsho	5817	17	a	a	DT
cord-006229-7yoilsho	5817	18	protein	protein	NN
cord-006229-7yoilsho	5817	19	-	-	HYPH
cord-006229-7yoilsho	5817	20	binding	bind	VBG
cord-006229-7yoilsho	5817	21	potential	potential	NN
cord-006229-7yoilsho	5817	22	.	.	.
cord-006229-7yoilsho	5818	1	For	for	IN
cord-006229-7yoilsho	5818	2	a	a	DT
cord-006229-7yoilsho	5818	3	complete	complete	JJ
cord-006229-7yoilsho	5818	4	risk	risk	NN
cord-006229-7yoilsho	5818	5	assessment	assessment	NN
cord-006229-7yoilsho	5818	6	,	,	,
cord-006229-7yoilsho	5818	7	however	however	RB
cord-006229-7yoilsho	5818	8	,	,	,
cord-006229-7yoilsho	5818	9	an	an	DT
cord-006229-7yoilsho	5818	10	estimation	estimation	NN
cord-006229-7yoilsho	5818	11	of	of	IN
cord-006229-7yoilsho	5818	12	a	a	DT
cord-006229-7yoilsho	5818	13	chemical	chemical	NN
cord-006229-7yoilsho	5818	14	's	's	POS
cord-006229-7yoilsho	5818	15	potency	potency	NN
cord-006229-7yoilsho	5818	16	is	be	VBZ
cord-006229-7yoilsho	5818	17	also	also	RB
cord-006229-7yoilsho	5818	18	needed	need	VBN
cord-006229-7yoilsho	5818	19	.	.	.
cord-006229-7yoilsho	5819	1	In	in	IN
cord-006229-7yoilsho	5819	2	this	this	DT
cord-006229-7yoilsho	5819	3	study	study	NN
cord-006229-7yoilsho	5819	4	we	-PRON-	PRP
cord-006229-7yoilsho	5819	5	examined	examine	VBD
cord-006229-7yoilsho	5819	6	if	if	IN
cord-006229-7yoilsho	5819	7	an	an	DT
cord-006229-7yoilsho	5819	8	assessment	assessment	NN
cord-006229-7yoilsho	5819	9	of	of	IN
cord-006229-7yoilsho	5819	10	potency	potency	NN
cord-006229-7yoilsho	5819	11	could	could	MD
cord-006229-7yoilsho	5819	12	be	be	VB
cord-006229-7yoilsho	5819	13	achieved	achieve	VBN
cord-006229-7yoilsho	5819	14	by	by	IN
cord-006229-7yoilsho	5819	15	1	1	CD
cord-006229-7yoilsho	5819	16	)	)	-RRB-
cord-006229-7yoilsho	5819	17	determining	determine	VBG
cord-006229-7yoilsho	5819	18	reactivity	reactivity	NN
cord-006229-7yoilsho	5819	19	class	class	NN
cord-006229-7yoilsho	5819	20	cut	cut	NN
cord-006229-7yoilsho	5819	21	offs	off	NNS
cord-006229-7yoilsho	5819	22	based	base	VBN
cord-006229-7yoilsho	5819	23	on	on	IN
cord-006229-7yoilsho	5819	24	published	publish	VBN
cord-006229-7yoilsho	5819	25	data	datum	NNS
cord-006229-7yoilsho	5819	26	on	on	IN
cord-006229-7yoilsho	5819	27	199	199	CD
cord-006229-7yoilsho	5819	28	substances	substance	NNS
cord-006229-7yoilsho	5819	29	for	for	IN
cord-006229-7yoilsho	5819	30	the	the	DT
cord-006229-7yoilsho	5819	31	DPRA	DPRA	NNP
cord-006229-7yoilsho	5819	32	performed	perform	VBN
cord-006229-7yoilsho	5819	33	according	accord	VBG
cord-006229-7yoilsho	5819	34	to	to	IN
cord-006229-7yoilsho	5819	35	OECD	OECD	NNP
cord-006229-7yoilsho	5819	36	442C	442c	CD
cord-006229-7yoilsho	5819	37	to	to	TO
cord-006229-7yoilsho	5819	38	predict	predict	VB
cord-006229-7yoilsho	5819	39	UN	UN	NNP
cord-006229-7yoilsho	5819	40	GHS	GHS	NNP
cord-006229-7yoilsho	5819	41	sensitizer	sensitizer	NN
cord-006229-7yoilsho	5819	42	classes	class	NNS
cord-006229-7yoilsho	5819	43	,	,	,
cord-006229-7yoilsho	5819	44	2	2	CD
cord-006229-7yoilsho	5819	45	)	)	-RRB-
cord-006229-7yoilsho	5819	46	a	a	DT
cord-006229-7yoilsho	5819	47	variant	variant	NN
cord-006229-7yoilsho	5819	48	of	of	IN
cord-006229-7yoilsho	5819	49	the	the	DT
cord-006229-7yoilsho	5819	50	DPRA	DPRA	NNP
cord-006229-7yoilsho	5819	51	assessing	assess	VBG
cord-006229-7yoilsho	5819	52	reaction	reaction	NN
cord-006229-7yoilsho	5819	53	kinetics	kinetics	NN
cord-006229-7yoilsho	5819	54	(	(	-LRB-
cord-006229-7yoilsho	5819	55	time	time	NN
cord-006229-7yoilsho	5819	56	and	and	CC
cord-006229-7yoilsho	5819	57	concentration	concentration	NN
cord-006229-7yoilsho	5819	58	)	)	-RRB-
cord-006229-7yoilsho	5819	59	for	for	IN
cord-006229-7yoilsho	5819	60	12	12	CD
cord-006229-7yoilsho	5819	61	substances	substance	NNS
cord-006229-7yoilsho	5819	62	or	or	CC
cord-006229-7yoilsho	5819	63	3	3	CD
cord-006229-7yoilsho	5819	64	)	)	-RRB-
cord-006229-7yoilsho	5820	1	an	an	DT
cord-006229-7yoilsho	5820	2	extended	extended	JJ
cord-006229-7yoilsho	5820	3	protocol	protocol	NN
cord-006229-7yoilsho	5820	4	testing	test	VBG
cord-006229-7yoilsho	5820	5	several	several	JJ
cord-006229-7yoilsho	5820	6	test	test	NN
cord-006229-7yoilsho	5820	7	substance	substance	NN
cord-006229-7yoilsho	5820	8	concentrations	concentration	NNS
cord-006229-7yoilsho	5820	9	for	for	IN
cord-006229-7yoilsho	5820	10	50	50	CD
cord-006229-7yoilsho	5820	11	reference	reference	NN
cord-006229-7yoilsho	5820	12	substances	substance	NNS
cord-006229-7yoilsho	5820	13	and	and	CC
cord-006229-7yoilsho	5820	14	estimating	estimate	VBG
cord-006229-7yoilsho	5820	15	the	the	DT
cord-006229-7yoilsho	5820	16	concentration	concentration	NN
cord-006229-7yoilsho	5820	17	of	of	IN
cord-006229-7yoilsho	5820	18	a	a	DT
cord-006229-7yoilsho	5820	19	test	test	NN
cord-006229-7yoilsho	5820	20	substance	substance	NN
cord-006229-7yoilsho	5820	21	that	that	WDT
cord-006229-7yoilsho	5820	22	is	be	VBZ
cord-006229-7yoilsho	5820	23	needed	need	VBN
cord-006229-7yoilsho	5820	24	to	to	TO
cord-006229-7yoilsho	5820	25	cause	cause	VB
cord-006229-7yoilsho	5820	26	a	a	DT
cord-006229-7yoilsho	5820	27	peptide	peptide	JJ
cord-006229-7yoilsho	5820	28	depletion	depletion	NN
cord-006229-7yoilsho	5820	29	of	of	IN
cord-006229-7yoilsho	5820	30	6.38	6.38	CD
cord-006229-7yoilsho	5820	31	%	%	NN
cord-006229-7yoilsho	5820	32	(	(	-LRB-
cord-006229-7yoilsho	5820	33	EC6.38	EC6.38	NNP
cord-006229-7yoilsho	5820	34	%	%	NN
cord-006229-7yoilsho	5820	35	)	)	-RRB-
cord-006229-7yoilsho	5820	36	.	.	.
cord-006229-7yoilsho	5821	1	Results	result	NNS
cord-006229-7yoilsho	5821	2	of	of	IN
cord-006229-7yoilsho	5821	3	the	the	DT
cord-006229-7yoilsho	5821	4	first	first	JJ
cord-006229-7yoilsho	5821	5	approach	approach	NN
cord-006229-7yoilsho	5821	6	indicated	indicate	VBD
cord-006229-7yoilsho	5821	7	that	that	IN
cord-006229-7yoilsho	5821	8	cut	cut	VBN
cord-006229-7yoilsho	5821	9	offs	off	NNS
cord-006229-7yoilsho	5821	10	to	to	TO
cord-006229-7yoilsho	5821	11	differentiate	differentiate	VB
cord-006229-7yoilsho	5821	12	the	the	DT
cord-006229-7yoilsho	5821	13	UN	UN	NNP
cord-006229-7yoilsho	5821	14	GHS	GHS	NNP
cord-006229-7yoilsho	5821	15	sensitizer	sensitizer	NN
cord-006229-7yoilsho	5821	16	classes	class	NNS
cord-006229-7yoilsho	5821	17	1A	1a	NN
cord-006229-7yoilsho	5821	18	and	and	CC
cord-006229-7yoilsho	5821	19	1B	1b	NN
cord-006229-7yoilsho	5821	20	could	could	MD
cord-006229-7yoilsho	5821	21	indeed	indeed	RB
cord-006229-7yoilsho	5821	22	be	be	VB
cord-006229-7yoilsho	5821	23	defined	define	VBN
cord-006229-7yoilsho	5821	24	.	.	.
cord-006229-7yoilsho	5822	1	Secondly	secondly	RB
cord-006229-7yoilsho	5822	2	,	,	,
cord-006229-7yoilsho	5822	3	evaluating	evaluate	VBG
cord-006229-7yoilsho	5822	4	the	the	DT
cord-006229-7yoilsho	5822	5	reaction	reaction	NN
cord-006229-7yoilsho	5822	6	time	time	NN
cord-006229-7yoilsho	5822	7	based	base	VBN
cord-006229-7yoilsho	5822	8	assay	assay	NN
cord-006229-7yoilsho	5822	9	in	in	IN
cord-006229-7yoilsho	5822	10	which	which	WDT
cord-006229-7yoilsho	5822	11	several	several	JJ
cord-006229-7yoilsho	5822	12	time	time	NN
cord-006229-7yoilsho	5822	13	points	point	NNS
cord-006229-7yoilsho	5822	14	between	between	IN
cord-006229-7yoilsho	5822	15	5	5	CD
cord-006229-7yoilsho	5822	16	min	min	NN
cord-006229-7yoilsho	5822	17	and	and	CC
cord-006229-7yoilsho	5822	18	24	24	CD
cord-006229-7yoilsho	5822	19	hours	hour	NNS
cord-006229-7yoilsho	5822	20	were	be	VBD
cord-006229-7yoilsho	5822	21	assessed	assess	VBN
cord-006229-7yoilsho	5822	22	,	,	,
cord-006229-7yoilsho	5822	23	it	-PRON-	PRP
cord-006229-7yoilsho	5822	24	was	be	VBD
cord-006229-7yoilsho	5822	25	found	find	VBN
cord-006229-7yoilsho	5822	26	that	that	IN
cord-006229-7yoilsho	5822	27	not	not	RB
cord-006229-7yoilsho	5822	28	all	all	DT
cord-006229-7yoilsho	5822	29	reactions	reaction	NNS
cord-006229-7yoilsho	5822	30	followed	follow	VBD
cord-006229-7yoilsho	5822	31	ideal	ideal	JJ
cord-006229-7yoilsho	5822	32	kinetics	kinetic	NNS
cord-006229-7yoilsho	5822	33	.	.	.
cord-006229-7yoilsho	5823	1	Hence	hence	RB
cord-006229-7yoilsho	5823	2	further	further	JJ
cord-006229-7yoilsho	5823	3	investigations	investigation	NNS
cord-006229-7yoilsho	5823	4	are	be	VBP
cord-006229-7yoilsho	5823	5	needed	need	VBN
cord-006229-7yoilsho	5823	6	to	to	TO
cord-006229-7yoilsho	5823	7	eventually	eventually	RB
cord-006229-7yoilsho	5823	8	derive	derive	VB
cord-006229-7yoilsho	5823	9	a	a	DT
cord-006229-7yoilsho	5823	10	reaction	reaction	NN
cord-006229-7yoilsho	5823	11	time	time	NN
cord-006229-7yoilsho	5823	12	based	base	VBN
cord-006229-7yoilsho	5823	13	prediction	prediction	NN
cord-006229-7yoilsho	5823	14	model	model	NN
cord-006229-7yoilsho	5823	15	.	.	.
cord-006229-7yoilsho	5824	1	The	the	DT
cord-006229-7yoilsho	5824	2	results	result	NNS
cord-006229-7yoilsho	5824	3	of	of	IN
cord-006229-7yoilsho	5824	4	the	the	DT
cord-006229-7yoilsho	5824	5	3	3	CD
cord-006229-7yoilsho	5824	6	rd	rd	NNP
cord-006229-7yoilsho	5824	7	approach	approach	NN
cord-006229-7yoilsho	5824	8	(	(	-LRB-
cord-006229-7yoilsho	5824	9	the	the	DT
cord-006229-7yoilsho	5824	10	standard	standard	JJ
cord-006229-7yoilsho	5824	11	protocol	protocol	NN
cord-006229-7yoilsho	5824	12	of	of	IN
cord-006229-7yoilsho	5824	13	the	the	DT
cord-006229-7yoilsho	5824	14	DPRA	DPRA	NNP
cord-006229-7yoilsho	5824	15	was	be	VBD
cord-006229-7yoilsho	5824	16	amended	amend	VBN
cord-006229-7yoilsho	5824	17	by	by	IN
cord-006229-7yoilsho	5824	18	testing	test	VBG
cord-006229-7yoilsho	5824	19	three	three	CD
cord-006229-7yoilsho	5824	20	concentrations	concentration	NNS
cord-006229-7yoilsho	5824	21	i.e.	i.e.	FW
cord-006229-7yoilsho	5824	22	1	1	CD
cord-006229-7yoilsho	5824	23	,	,	,
cord-006229-7yoilsho	5824	24	10	10	CD
cord-006229-7yoilsho	5824	25	,	,	,
cord-006229-7yoilsho	5824	26	and	and	CC
cord-006229-7yoilsho	5824	27	100	100	CD
cord-006229-7yoilsho	5824	28	mM	mm	CD
cord-006229-7yoilsho	5824	29	)	)	-RRB-
cord-006229-7yoilsho	5824	30	indicated	indicate	VBD
cord-006229-7yoilsho	5824	31	that	that	IN
cord-006229-7yoilsho	5824	32	potency	potency	NN
cord-006229-7yoilsho	5824	33	classes	class	NNS
cord-006229-7yoilsho	5824	34	could	could	MD
cord-006229-7yoilsho	5824	35	be	be	VB
cord-006229-7yoilsho	5824	36	assigned	assign	VBN
cord-006229-7yoilsho	5824	37	using	use	VBG
cord-006229-7yoilsho	5824	38	the	the	DT
cord-006229-7yoilsho	5824	39	EC6.38	EC6.38	NNP
cord-006229-7yoilsho	5824	40	%	%	NN
cord-006229-7yoilsho	5824	41	value	value	NN
cord-006229-7yoilsho	5824	42	to	to	TO
cord-006229-7yoilsho	5824	43	assess	assess	VB
cord-006229-7yoilsho	5824	44	potency	potency	NN
cord-006229-7yoilsho	5824	45	.	.	.
cord-006229-7yoilsho	5825	1	In	in	IN
cord-006229-7yoilsho	5825	2	summary	summary	NN
cord-006229-7yoilsho	5825	3	,	,	,
cord-006229-7yoilsho	5825	4	using	use	VBG
cord-006229-7yoilsho	5825	5	quantitative	quantitative	JJ
cord-006229-7yoilsho	5825	6	information	information	NN
cord-006229-7yoilsho	5825	7	derived	derive	VBN
cord-006229-7yoilsho	5825	8	from	from	IN
cord-006229-7yoilsho	5825	9	the	the	DT
cord-006229-7yoilsho	5825	10	DPRA	DPRA	NNP
cord-006229-7yoilsho	5825	11	in	in	IN
cord-006229-7yoilsho	5825	12	particular	particular	JJ
cord-006229-7yoilsho	5825	13	using	use	VBG
cord-006229-7yoilsho	5825	14	EC6.38	EC6.38	NNP
cord-006229-7yoilsho	5825	15	%	%	NN
cord-006229-7yoilsho	5825	16	value	value	NN
cord-006229-7yoilsho	5825	17	may	may	MD
cord-006229-7yoilsho	5825	18	support	support	VB
cord-006229-7yoilsho	5825	19	the	the	DT
cord-006229-7yoilsho	5825	20	assessment	assessment	NN
cord-006229-7yoilsho	5825	21	of	of	IN
cord-006229-7yoilsho	5825	22	the	the	DT
cord-006229-7yoilsho	5825	23	skin	skin	NN
cord-006229-7yoilsho	5825	24	sensitizing	sensitize	VBG
cord-006229-7yoilsho	5825	25	potency	potency	NN
cord-006229-7yoilsho	5825	26	.	.	.
cord-006229-7yoilsho	5826	1	Identification	identification	NN
cord-006229-7yoilsho	5826	2	of	of	IN
cord-006229-7yoilsho	5826	3	pre	pre	JJ
cord-006229-7yoilsho	5826	4	-	-	JJ
cord-006229-7yoilsho	5826	5	and	and	CC
cord-006229-7yoilsho	5826	6	pro	pro	NNS
cord-006229-7yoilsho	5826	7	-	-	NNS
cord-006229-7yoilsho	5826	8	haptens	hapten	NNS
cord-006229-7yoilsho	5826	9	with	with	IN
cord-006229-7yoilsho	5826	10	non	non	JJ
cord-006229-7yoilsho	5826	11	-	-	JJ
cord-006229-7yoilsho	5826	12	animal	animal	JJ
cord-006229-7yoilsho	5826	13	test	test	NN
cord-006229-7yoilsho	5826	14	methods	method	NNS
cord-006229-7yoilsho	5826	15	for	for	IN
cord-006229-7yoilsho	5826	16	skin	skin	NN
cord-006229-7yoilsho	5826	17	sensitization	sensitization	NN
cord-006229-7yoilsho	5826	18	Since	since	IN
cord-006229-7yoilsho	5826	19	pro	pro	JJ
cord-006229-7yoilsho	5826	20	-	-	NNS
cord-006229-7yoilsho	5826	21	haptens	hapten	NNS
cord-006229-7yoilsho	5826	22	may	may	MD
cord-006229-7yoilsho	5826	23	be	be	VB
cord-006229-7yoilsho	5826	24	metabolically	metabolically	RB
cord-006229-7yoilsho	5826	25	activated	activate	VBN
cord-006229-7yoilsho	5826	26	in	in	IN
cord-006229-7yoilsho	5826	27	the	the	DT
cord-006229-7yoilsho	5826	28	skin	skin	NN
cord-006229-7yoilsho	5826	29	,	,	,
cord-006229-7yoilsho	5826	30	information	information	NN
cord-006229-7yoilsho	5826	31	on	on	IN
cord-006229-7yoilsho	5826	32	xenobiotic	xenobiotic	JJ
cord-006229-7yoilsho	5826	33	metabolizing	metabolizing	NN
cord-006229-7yoilsho	5826	34	enzyme	enzyme	NN
cord-006229-7yoilsho	5826	35	(	(	-LRB-
cord-006229-7yoilsho	5826	36	XME	xme	NN
cord-006229-7yoilsho	5826	37	)	)	-RRB-
cord-006229-7yoilsho	5826	38	activities	activity	NNS
cord-006229-7yoilsho	5826	39	in	in	IN
cord-006229-7yoilsho	5826	40	cell	cell	NN
cord-006229-7yoilsho	5826	41	lines	line	NNS
cord-006229-7yoilsho	5826	42	used	use	VBN
cord-006229-7yoilsho	5826	43	for	for	IN
cord-006229-7yoilsho	5826	44	testing	testing	NN
cord-006229-7yoilsho	5826	45	of	of	IN
cord-006229-7yoilsho	5826	46	sensitization	sensitization	NN
cord-006229-7yoilsho	5826	47	in	in	IN
cord-006229-7yoilsho	5826	48	vitro	vitro	FW
cord-006229-7yoilsho	5826	49	is	be	VBZ
cord-006229-7yoilsho	5826	50	of	of	IN
cord-006229-7yoilsho	5826	51	special	special	JJ
cord-006229-7yoilsho	5826	52	interest	interest	NN
cord-006229-7yoilsho	5826	53	.	.	.
cord-006229-7yoilsho	5827	1	Metabolic	metabolic	JJ
cord-006229-7yoilsho	5827	2	activity	activity	NN
cord-006229-7yoilsho	5827	3	of	of	IN
cord-006229-7yoilsho	5827	4	e.g.	e.g.	RB
cord-006229-7yoilsho	5827	5	N	N	NNP
cord-006229-7yoilsho	5827	6	-	-	HYPH
cord-006229-7yoilsho	5827	7	acetyltransferase	acetyltransferase	NNP
cord-006229-7yoilsho	5827	8	1	1	CD
cord-006229-7yoilsho	5827	9	(	(	-LRB-
cord-006229-7yoilsho	5827	10	NAT1	NAT1	NNP
cord-006229-7yoilsho	5827	11	)	)	-RRB-
cord-006229-7yoilsho	5827	12	and	and	CC
cord-006229-7yoilsho	5827	13	esterase	esterase	NN
cord-006229-7yoilsho	5827	14	in	in	IN
cord-006229-7yoilsho	5827	15	the	the	DT
cord-006229-7yoilsho	5827	16	keratinocyte	keratinocyte	NN
cord-006229-7yoilsho	5827	17	(	(	-LRB-
cord-006229-7yoilsho	5827	18	KeratinoSens	KeratinoSens	NNP
cord-006229-7yoilsho	5827	19	TM	TM	NNP
cord-006229-7yoilsho	5827	20	and	and	CC
cord-006229-7yoilsho	5827	21	LuSens	LuSens	NNP
cord-006229-7yoilsho	5827	22	)	)	-RRB-
cord-006229-7yoilsho	5827	23	and	and	CC
cord-006229-7yoilsho	5827	24	dendritic	dendritic	JJ
cord-006229-7yoilsho	5827	25	cell	cell	NN
cord-006229-7yoilsho	5827	26	-	-	HYPH
cord-006229-7yoilsho	5827	27	like	like	JJ
cord-006229-7yoilsho	5827	28	cells	cell	NNS
cord-006229-7yoilsho	5827	29	(	(	-LRB-
cord-006229-7yoilsho	5827	30	U937	U937	NNP
cord-006229-7yoilsho	5827	31	and	and	CC
cord-006229-7yoilsho	5827	32	THP-1	THP-1	NNP
cord-006229-7yoilsho	5827	33	)	)	-RRB-
cord-006229-7yoilsho	5827	34	was	be	VBD
cord-006229-7yoilsho	5827	35	previously	previously	RB
cord-006229-7yoilsho	5827	36	demonstrated	demonstrate	VBN
cord-006229-7yoilsho	5827	37	.	.	.
cord-006229-7yoilsho	5828	1	Aldehyde	Aldehyde	NNP
cord-006229-7yoilsho	5828	2	dehydrogenase	dehydrogenase	NN
cord-006229-7yoilsho	5828	3	(	(	-LRB-
cord-006229-7yoilsho	5828	4	ALDH	ALDH	NNP
cord-006229-7yoilsho	5828	5	)	)	-RRB-
cord-006229-7yoilsho	5828	6	activities	activity	NNS
cord-006229-7yoilsho	5828	7	were	be	VBD
cord-006229-7yoilsho	5828	8	found	find	VBN
cord-006229-7yoilsho	5828	9	in	in	IN
cord-006229-7yoilsho	5828	10	KeratinoSens	KeratinoSens	NNP
cord-006229-7yoilsho	5828	11	TM	TM	NNP
cord-006229-7yoilsho	5828	12	and	and	CC
cord-006229-7yoilsho	5828	13	LuSens	LuSens	NNP
cord-006229-7yoilsho	5828	14	cells	cell	NNS
cord-006229-7yoilsho	5828	15	.	.	.
cord-006229-7yoilsho	5829	1	Activities	activity	NNS
cord-006229-7yoilsho	5829	2	of	of	IN
cord-006229-7yoilsho	5829	3	the	the	DT
cord-006229-7yoilsho	5829	4	investigated	investigate	VBN
cord-006229-7yoilsho	5829	5	cytochrome	cytochrome	NN
cord-006229-7yoilsho	5829	6	P450-dependent	p450-dependent	NN
cord-006229-7yoilsho	5829	7	alkylresorufin	alkylresorufin	NNP
cord-006229-7yoilsho	5829	8	O	o	NN
cord-006229-7yoilsho	5829	9	-	-	HYPH
cord-006229-7yoilsho	5829	10	dealkylases	dealkylase	NNS
cord-006229-7yoilsho	5829	11	,	,	,
cord-006229-7yoilsho	5829	12	flavin	flavin	NN
cord-006229-7yoilsho	5829	13	-	-	HYPH
cord-006229-7yoilsho	5829	14	containing	contain	VBG
cord-006229-7yoilsho	5829	15	monooxygenase	monooxygenase	NN
cord-006229-7yoilsho	5829	16	,	,	,
cord-006229-7yoilsho	5829	17	alcohol	alcohol	NN
cord-006229-7yoilsho	5829	18	dehydrogenase	dehydrogenase	NN
cord-006229-7yoilsho	5829	19	as	as	RB
cord-006229-7yoilsho	5829	20	well	well	RB
cord-006229-7yoilsho	5829	21	as	as	IN
cord-006229-7yoilsho	5829	22	UDP	UDP	NNP
cord-006229-7yoilsho	5829	23	glucuronosyl	glucuronosyl	NN
cord-006229-7yoilsho	5829	24	transferase	transferase	NN
cord-006229-7yoilsho	5829	25	activities	activity	NNS
cord-006229-7yoilsho	5829	26	were	be	VBD
cord-006229-7yoilsho	5829	27	below	below	IN
cord-006229-7yoilsho	5829	28	detection	detection	NN
cord-006229-7yoilsho	5829	29	in	in	IN
cord-006229-7yoilsho	5829	30	all	all	DT
cord-006229-7yoilsho	5829	31	investigated	investigate	VBN
cord-006229-7yoilsho	5829	32	cell	cell	NN
cord-006229-7yoilsho	5829	33	lines	line	NNS
cord-006229-7yoilsho	5829	34	.	.	.
cord-006229-7yoilsho	5830	1	A	a	DT
cord-006229-7yoilsho	5830	2	set	set	NN
cord-006229-7yoilsho	5830	3	of	of	IN
cord-006229-7yoilsho	5830	4	27	27	CD
cord-006229-7yoilsho	5830	5	putative	putative	JJ
cord-006229-7yoilsho	5830	6	pre	pre	JJ
cord-006229-7yoilsho	5830	7	-	-	JJ
cord-006229-7yoilsho	5830	8	and	and	CC
cord-006229-7yoilsho	5830	9	pro	pro	NNS
cord-006229-7yoilsho	5830	10	-	-	NNS
cord-006229-7yoilsho	5830	11	haptens	haptens	JJ
cord-006229-7yoilsho	5830	12	(	(	-LRB-
cord-006229-7yoilsho	5830	13	no	no	DT
cord-006229-7yoilsho	5830	14	obvious	obvious	JJ
cord-006229-7yoilsho	5830	15	structural	structural	JJ
cord-006229-7yoilsho	5830	16	alert	alert	NN
cord-006229-7yoilsho	5830	17	for	for	IN
cord-006229-7yoilsho	5830	18	peptide	peptide	JJ
cord-006229-7yoilsho	5830	19	reactivity	reactivity	NN
cord-006229-7yoilsho	5830	20	but	but	CC
cord-006229-7yoilsho	5830	21	positive	positive	JJ
cord-006229-7yoilsho	5830	22	in	in	IN
cord-006229-7yoilsho	5830	23	vivo	vivo	NN
cord-006229-7yoilsho	5830	24	)	)	-RRB-
cord-006229-7yoilsho	5830	25	was	be	VBD
cord-006229-7yoilsho	5830	26	routinely	routinely	RB
cord-006229-7yoilsho	5830	27	tested	test	VBN
cord-006229-7yoilsho	5830	28	using	use	VBG
cord-006229-7yoilsho	5830	29	the	the	DT
cord-006229-7yoilsho	5830	30	above	above	RB
cord-006229-7yoilsho	5830	31	mentioned	mention	VBN
cord-006229-7yoilsho	5830	32	cell	cell	NN
cord-006229-7yoilsho	5830	33	lines	line	NNS
cord-006229-7yoilsho	5830	34	as	as	RB
cord-006229-7yoilsho	5830	35	well	well	RB
cord-006229-7yoilsho	5830	36	as	as	IN
cord-006229-7yoilsho	5830	37	in	in	IN
cord-006229-7yoilsho	5830	38	the	the	DT
cord-006229-7yoilsho	5830	39	direct	direct	JJ
cord-006229-7yoilsho	5830	40	peptide	peptide	NN
cord-006229-7yoilsho	5830	41	reactivity	reactivity	NN
cord-006229-7yoilsho	5830	42	assay	assay	NN
cord-006229-7yoilsho	5830	43	(	(	-LRB-
cord-006229-7yoilsho	5830	44	DPRA	DPRA	NNP
cord-006229-7yoilsho	5830	45	)	)	-RRB-
cord-006229-7yoilsho	5830	46	.	.	.
cord-006229-7yoilsho	5831	1	18	18	CD
cord-006229-7yoilsho	5831	2	of	of	IN
cord-006229-7yoilsho	5831	3	the	the	DT
cord-006229-7yoilsho	5831	4	compounds	compound	NNS
cord-006229-7yoilsho	5831	5	were	be	VBD
cord-006229-7yoilsho	5831	6	unexpectedly	unexpectedly	RB
cord-006229-7yoilsho	5831	7	positive	positive	JJ
cord-006229-7yoilsho	5831	8	in	in	IN
cord-006229-7yoilsho	5831	9	the	the	DT
cord-006229-7yoilsho	5831	10	DPRA	DPRA	NNS
cord-006229-7yoilsho	5831	11	und	und	IN
cord-006229-7yoilsho	5831	12	further	further	RB
cord-006229-7yoilsho	5831	13	analyzed	analyze	VBN
cord-006229-7yoilsho	5831	14	by	by	IN
cord-006229-7yoilsho	5831	15	LC	LC	NNP
cord-006229-7yoilsho	5831	16	/	/	SYM
cord-006229-7yoilsho	5831	17	MS	MS	NNP
cord-006229-7yoilsho	5831	18	techniques	technique	NNS
cord-006229-7yoilsho	5831	19	to	to	TO
cord-006229-7yoilsho	5831	20	clarify	clarify	VB
cord-006229-7yoilsho	5831	21	the	the	DT
cord-006229-7yoilsho	5831	22	reaction	reaction	NN
cord-006229-7yoilsho	5831	23	mechanism	mechanism	NN
cord-006229-7yoilsho	5831	24	leading	lead	VBG
cord-006229-7yoilsho	5831	25	to	to	IN
cord-006229-7yoilsho	5831	26	true	true	JJ
cord-006229-7yoilsho	5831	27	positive	positive	JJ
cord-006229-7yoilsho	5831	28	results	result	NNS
cord-006229-7yoilsho	5831	29	in	in	IN
cord-006229-7yoilsho	5831	30	this	this	DT
cord-006229-7yoilsho	5831	31	assay	assay	NN
cord-006229-7yoilsho	5831	32	.	.	.
cord-006229-7yoilsho	5832	1	Oxidation	oxidation	NN
cord-006229-7yoilsho	5832	2	products	product	NNS
cord-006229-7yoilsho	5832	3	like	like	IN
cord-006229-7yoilsho	5832	4	dipeptide	dipeptide	NN
cord-006229-7yoilsho	5832	5	formations	formation	NNS
cord-006229-7yoilsho	5832	6	or	or	CC
cord-006229-7yoilsho	5832	7	the	the	DT
cord-006229-7yoilsho	5832	8	oxidation	oxidation	NN
cord-006229-7yoilsho	5832	9	of	of	IN
cord-006229-7yoilsho	5832	10	the	the	DT
cord-006229-7yoilsho	5832	11	peptide	peptide	NN
cord-006229-7yoilsho	5832	12	-	-	HYPH
cord-006229-7yoilsho	5832	13	based	base	VBN
cord-006229-7yoilsho	5832	14	sulfhydryl	sulfhydryl	NN
cord-006229-7yoilsho	5832	15	group	group	NN
cord-006229-7yoilsho	5832	16	led	lead	VBD
cord-006229-7yoilsho	5832	17	to	to	IN
cord-006229-7yoilsho	5832	18	positive	positive	JJ
cord-006229-7yoilsho	5832	19	results	result	NNS
cord-006229-7yoilsho	5832	20	for	for	IN
cord-006229-7yoilsho	5832	21	benzo[a]pyren	benzo[a]pyren	NNS
cord-006229-7yoilsho	5832	22	or	or	CC
cord-006229-7yoilsho	5832	23	5-amino-2-methylphenol	5-amino-2-methylphenol	CD
cord-006229-7yoilsho	5832	24	,	,	,
cord-006229-7yoilsho	5832	25	respectively	respectively	RB
cord-006229-7yoilsho	5832	26	.	.	.
cord-006229-7yoilsho	5833	1	In	in	IN
cord-006229-7yoilsho	5833	2	contrast	contrast	NN
cord-006229-7yoilsho	5833	3	,	,	,
cord-006229-7yoilsho	5833	4	covalent	covalent	JJ
cord-006229-7yoilsho	5833	5	peptide	peptide	NN
cord-006229-7yoilsho	5833	6	adducts	adduct	NNS
cord-006229-7yoilsho	5833	7	were	be	VBD
cord-006229-7yoilsho	5833	8	identified	identify	VBN
cord-006229-7yoilsho	5833	9	for	for	IN
cord-006229-7yoilsho	5833	10	12	12	CD
cord-006229-7yoilsho	5833	11	putative	putative	JJ
cord-006229-7yoilsho	5833	12	pre	pre	NNS
cord-006229-7yoilsho	5833	13	-	-	NNS
cord-006229-7yoilsho	5833	14	haptens	hapten	NNS
cord-006229-7yoilsho	5833	15	,	,	,
cord-006229-7yoilsho	5833	16	indicating	indicate	VBG
cord-006229-7yoilsho	5833	17	the	the	DT
cord-006229-7yoilsho	5833	18	DPRA	DPRA	NNP
cord-006229-7yoilsho	5833	19	to	to	TO
cord-006229-7yoilsho	5833	20	be	be	VB
cord-006229-7yoilsho	5833	21	suitable	suitable	JJ
cord-006229-7yoilsho	5833	22	for	for	IN
cord-006229-7yoilsho	5833	23	compounds	compound	NNS
cord-006229-7yoilsho	5833	24	requiring	require	VBG
cord-006229-7yoilsho	5833	25	abiotic	abiotic	JJ
cord-006229-7yoilsho	5833	26	oxidation	oxidation	NN
cord-006229-7yoilsho	5833	27	to	to	TO
cord-006229-7yoilsho	5833	28	get	get	VB
cord-006229-7yoilsho	5833	29	activated	activate	VBN
cord-006229-7yoilsho	5833	30	.	.	.
cord-006229-7yoilsho	5834	1	For	for	IN
cord-006229-7yoilsho	5834	2	some	some	DT
cord-006229-7yoilsho	5834	3	DPRA	DPRA	NNP
cord-006229-7yoilsho	5834	4	negatives	negative	NNS
cord-006229-7yoilsho	5834	5	,	,	,
cord-006229-7yoilsho	5834	6	the	the	DT
cord-006229-7yoilsho	5834	7	keratinocyte	keratinocyte	NNP
cord-006229-7yoilsho	5834	8	and	and	CC
cord-006229-7yoilsho	5834	9	dendritic	dendritic	JJ
cord-006229-7yoilsho	5834	10	cell	cell	NN
cord-006229-7yoilsho	5834	11	based	base	VBN
cord-006229-7yoilsho	5834	12	assays	assay	NNS
cord-006229-7yoilsho	5834	13	provided	provide	VBD
cord-006229-7yoilsho	5834	14	true	true	JJ
cord-006229-7yoilsho	5834	15	positive	positive	JJ
cord-006229-7yoilsho	5834	16	results	result	NNS
cord-006229-7yoilsho	5834	17	.	.	.
cord-006229-7yoilsho	5835	1	A	a	DT
cord-006229-7yoilsho	5835	2	combination	combination	NN
cord-006229-7yoilsho	5835	3	of	of	IN
cord-006229-7yoilsho	5835	4	DPRA	DPRA	NNP
cord-006229-7yoilsho	5835	5	,	,	,
cord-006229-7yoilsho	5835	6	KeratinoSens	KeratinoSens	NNP
cord-006229-7yoilsho	5835	7	TM	TM	NNP
cord-006229-7yoilsho	5835	8	and	and	CC
cord-006229-7yoilsho	5835	9	h	h	NN
cord-006229-7yoilsho	5835	10	-	-	HYPH
cord-006229-7yoilsho	5835	11	CLAT	CLAT	NNP
cord-006229-7yoilsho	5835	12	within	within	IN
cord-006229-7yoilsho	5835	13	a	a	DT
cord-006229-7yoilsho	5835	14	'	'	``
cord-006229-7yoilsho	5835	15	2	2	CD
cord-006229-7yoilsho	5835	16	out	out	IN
cord-006229-7yoilsho	5835	17	of	of	IN
cord-006229-7yoilsho	5835	18	3	3	CD
cord-006229-7yoilsho	5835	19	'	'	POS
cord-006229-7yoilsho	5835	20	prediction	prediction	NN
cord-006229-7yoilsho	5835	21	model	model	NN
cord-006229-7yoilsho	5835	22	provided	provide	VBD
cord-006229-7yoilsho	5835	23	a	a	DT
cord-006229-7yoilsho	5835	24	high	high	JJ
cord-006229-7yoilsho	5835	25	sensitivity	sensitivity	NN
cord-006229-7yoilsho	5835	26	of	of	IN
cord-006229-7yoilsho	5835	27	81	81	CD
cord-006229-7yoilsho	5835	28	%	%	NN
cord-006229-7yoilsho	5835	29	for	for	IN
cord-006229-7yoilsho	5835	30	the	the	DT
cord-006229-7yoilsho	5835	31	set	set	NN
cord-006229-7yoilsho	5835	32	of	of	IN
cord-006229-7yoilsho	5835	33	the	the	DT
cord-006229-7yoilsho	5835	34	pre-/pro	pre-/pro	NNP
cord-006229-7yoilsho	5835	35	-	-	HYPH
cord-006229-7yoilsho	5835	36	haptens	hapten	NNS
cord-006229-7yoilsho	5835	37	.	.	.
cord-006229-7yoilsho	5836	1	The	the	DT
cord-006229-7yoilsho	5836	2	sensitivity	sensitivity	NN
cord-006229-7yoilsho	5836	3	of	of	IN
cord-006229-7yoilsho	5836	4	this	this	DT
cord-006229-7yoilsho	5836	5	combination	combination	NN
cord-006229-7yoilsho	5836	6	of	of	IN
cord-006229-7yoilsho	5836	7	non	non	JJ
cord-006229-7yoilsho	5836	8	-	-	JJ
cord-006229-7yoilsho	5836	9	animal	animal	JJ
cord-006229-7yoilsho	5836	10	test	test	NN
cord-006229-7yoilsho	5836	11	methods	method	NNS
cord-006229-7yoilsho	5836	12	in	in	IN
cord-006229-7yoilsho	5836	13	the	the	DT
cord-006229-7yoilsho	5836	14	'	'	``
cord-006229-7yoilsho	5836	15	2	2	CD
cord-006229-7yoilsho	5836	16	out	out	IN
cord-006229-7yoilsho	5836	17	of	of	IN
cord-006229-7yoilsho	5836	18	3	3	CD
cord-006229-7yoilsho	5836	19	'	'	POS
cord-006229-7yoilsho	5836	20	prediction	prediction	NN
cord-006229-7yoilsho	5836	21	model	model	NN
cord-006229-7yoilsho	5836	22	in	in	IN
cord-006229-7yoilsho	5836	23	a	a	DT
cord-006229-7yoilsho	5836	24	set	set	NN
cord-006229-7yoilsho	5836	25	of	of	IN
cord-006229-7yoilsho	5836	26	95	95	CD
cord-006229-7yoilsho	5836	27	direct	direct	JJ
cord-006229-7yoilsho	5836	28	haptens	hapten	NNS
cord-006229-7yoilsho	5836	29	was	be	VBD
cord-006229-7yoilsho	5836	30	comparable	comparable	JJ
cord-006229-7yoilsho	5836	31	(	(	-LRB-
cord-006229-7yoilsho	5836	32	sensitivity	sensitivity	NN
cord-006229-7yoilsho	5836	33	=	=	SYM
cord-006229-7yoilsho	5836	34	87	87	CD
cord-006229-7yoilsho	5836	35	%	%	NN
cord-006229-7yoilsho	5836	36	when	when	WRB
cord-006229-7yoilsho	5836	37	compared	compare	VBN
cord-006229-7yoilsho	5836	38	to	to	IN
cord-006229-7yoilsho	5836	39	LLNA	LLNA	NNP
cord-006229-7yoilsho	5836	40	Skin	Skin	NNP
cord-006229-7yoilsho	5836	41	sensitization	sensitization	NN
cord-006229-7yoilsho	5836	42	testing	testing	NN
cord-006229-7yoilsho	5836	43	is	be	VBZ
cord-006229-7yoilsho	5836	44	mandatory	mandatory	JJ
cord-006229-7yoilsho	5836	45	for	for	IN
cord-006229-7yoilsho	5836	46	all	all	DT
cord-006229-7yoilsho	5836	47	substances	substance	NNS
cord-006229-7yoilsho	5836	48	produced	produce	VBN
cord-006229-7yoilsho	5836	49	or	or	CC
cord-006229-7yoilsho	5836	50	marketed	market	VBN
cord-006229-7yoilsho	5836	51	in	in	IN
cord-006229-7yoilsho	5836	52	volumes	volume	NNS
cord-006229-7yoilsho	5836	53	larger	large	JJR
cord-006229-7yoilsho	5836	54	than	than	IN
cord-006229-7yoilsho	5836	55	1	1	CD
cord-006229-7yoilsho	5836	56	tonne	tonne	NN
cord-006229-7yoilsho	5836	57	per	per	IN
cord-006229-7yoilsho	5836	58	year	year	NN
cord-006229-7yoilsho	5836	59	under	under	IN
cord-006229-7yoilsho	5836	60	the	the	DT
cord-006229-7yoilsho	5836	61	European	european	JJ
cord-006229-7yoilsho	5836	62	REACH	REACH	NNP
cord-006229-7yoilsho	5836	63	legislation	legislation	NN
cord-006229-7yoilsho	5836	64	.	.	.
cord-006229-7yoilsho	5837	1	With	with	IN
cord-006229-7yoilsho	5837	2	REACH	reach	NN
cord-006229-7yoilsho	5837	3	supporting	support	VBG
cord-006229-7yoilsho	5837	4	in	in	IN
cord-006229-7yoilsho	5837	5	vivo	vivo	NN
cord-006229-7yoilsho	5837	6	testing	testing	NN
cord-006229-7yoilsho	5837	7	only	only	RB
cord-006229-7yoilsho	5837	8	"	"	''
cord-006229-7yoilsho	5837	9	as	as	IN
cord-006229-7yoilsho	5837	10	a	a	DT
cord-006229-7yoilsho	5837	11	last	last	JJ
cord-006229-7yoilsho	5837	12	resort	resort	NN
cord-006229-7yoilsho	5837	13	"	"	''
cord-006229-7yoilsho	5837	14	and	and	CC
cord-006229-7yoilsho	5837	15	the	the	DT
cord-006229-7yoilsho	5837	16	marketing	marketing	NN
cord-006229-7yoilsho	5837	17	ban	ban	NN
cord-006229-7yoilsho	5837	18	for	for	IN
cord-006229-7yoilsho	5837	19	finished	finished	JJ
cord-006229-7yoilsho	5837	20	cosmetic	cosmetic	JJ
cord-006229-7yoilsho	5837	21	products	product	NNS
cord-006229-7yoilsho	5837	22	with	with	IN
cord-006229-7yoilsho	5837	23	ingredients	ingredient	NNS
cord-006229-7yoilsho	5837	24	tested	test	VBN
cord-006229-7yoilsho	5837	25	in	in	IN
cord-006229-7yoilsho	5837	26	animals	animal	NNS
cord-006229-7yoilsho	5837	27	,	,	,
cord-006229-7yoilsho	5837	28	attention	attention	NN
cord-006229-7yoilsho	5837	29	has	have	VBZ
cord-006229-7yoilsho	5837	30	been	be	VBN
cord-006229-7yoilsho	5837	31	given	give	VBN
cord-006229-7yoilsho	5837	32	to	to	IN
cord-006229-7yoilsho	5837	33	developing	develop	VBG
cord-006229-7yoilsho	5837	34	integrated	integrate	VBN
cord-006229-7yoilsho	5837	35	testing	testing	NN
cord-006229-7yoilsho	5837	36	strategies	strategy	NNS
cord-006229-7yoilsho	5837	37	combining	combine	VBG
cord-006229-7yoilsho	5837	38	in	in	IN
cord-006229-7yoilsho	5837	39	vitro	vitro	FW
cord-006229-7yoilsho	5837	40	,	,	,
cord-006229-7yoilsho	5837	41	in	in	IN
cord-006229-7yoilsho	5837	42	silico	silico	NNS
cord-006229-7yoilsho	5837	43	and	and	CC
cord-006229-7yoilsho	5837	44	in	in	IN
cord-006229-7yoilsho	5837	45	chemico	chemico	NN
cord-006229-7yoilsho	5837	46	methods	method	NNS
cord-006229-7yoilsho	5837	47	.	.	.
cord-006229-7yoilsho	5838	1	Key	key	JJ
cord-006229-7yoilsho	5838	2	challenges	challenge	NNS
cord-006229-7yoilsho	5838	3	are	be	VBP
cord-006229-7yoilsho	5838	4	which	which	WDT
cord-006229-7yoilsho	5838	5	tests	test	NNS
cord-006229-7yoilsho	5838	6	to	to	TO
cord-006229-7yoilsho	5838	7	select	select	VB
cord-006229-7yoilsho	5838	8	and	and	CC
cord-006229-7yoilsho	5838	9	how	how	WRB
cord-006229-7yoilsho	5838	10	to	to	TO
cord-006229-7yoilsho	5838	11	combine	combine	VB
cord-006229-7yoilsho	5838	12	non	non	JJ
cord-006229-7yoilsho	5838	13	-	-	JJ
cord-006229-7yoilsho	5838	14	animal	animal	JJ
cord-006229-7yoilsho	5838	15	methods	method	NNS
cord-006229-7yoilsho	5838	16	into	into	IN
cord-006229-7yoilsho	5838	17	testing	testing	NN
cord-006229-7yoilsho	5838	18	strategies	strategy	NNS
cord-006229-7yoilsho	5838	19	.	.	.
cord-006229-7yoilsho	5839	1	This	this	DT
cord-006229-7yoilsho	5839	2	study	study	NN
cord-006229-7yoilsho	5839	3	suggests	suggest	VBZ
cord-006229-7yoilsho	5839	4	a	a	DT
cord-006229-7yoilsho	5839	5	Bayesian	bayesian	JJ
cord-006229-7yoilsho	5839	6	value	value	NN
cord-006229-7yoilsho	5839	7	of	of	IN
cord-006229-7yoilsho	5839	8	information	information	NN
cord-006229-7yoilsho	5839	9	(	(	-LRB-
cord-006229-7yoilsho	5839	10	VOI	VOI	NNP
cord-006229-7yoilsho	5839	11	)	)	-RRB-
cord-006229-7yoilsho	5839	12	approach	approach	NN
cord-006229-7yoilsho	5839	13	for	for	IN
cord-006229-7yoilsho	5839	14	developing	develop	VBG
cord-006229-7yoilsho	5839	15	non	non	JJ
cord-006229-7yoilsho	5839	16	-	-	JJ
cord-006229-7yoilsho	5839	17	animal	animal	JJ
cord-006229-7yoilsho	5839	18	testing	testing	NN
cord-006229-7yoilsho	5839	19	strategies	strategy	NNS
cord-006229-7yoilsho	5839	20	,	,	,
cord-006229-7yoilsho	5839	21	which	which	WDT
cord-006229-7yoilsho	5839	22	consider	consider	VBP
cord-006229-7yoilsho	5839	23	information	information	NN
cord-006229-7yoilsho	5839	24	gains	gain	NNS
cord-006229-7yoilsho	5839	25	from	from	IN
cord-006229-7yoilsho	5839	26	testing	testing	NN
cord-006229-7yoilsho	5839	27	,	,	,
cord-006229-7yoilsho	5839	28	but	but	CC
cord-006229-7yoilsho	5839	29	also	also	RB
cord-006229-7yoilsho	5839	30	expected	expect	VBD
cord-006229-7yoilsho	5839	31	payoffs	payoff	NNS
cord-006229-7yoilsho	5839	32	from	from	IN
cord-006229-7yoilsho	5839	33	adopting	adopt	VBG
cord-006229-7yoilsho	5839	34	regulatory	regulatory	JJ
cord-006229-7yoilsho	5839	35	decisions	decision	NNS
cord-006229-7yoilsho	5839	36	on	on	IN
cord-006229-7yoilsho	5839	37	the	the	DT
cord-006229-7yoilsho	5839	38	use	use	NN
cord-006229-7yoilsho	5839	39	of	of	IN
cord-006229-7yoilsho	5839	40	a	a	DT
cord-006229-7yoilsho	5839	41	substance	substance	NN
cord-006229-7yoilsho	5839	42	,	,	,
cord-006229-7yoilsho	5839	43	and	and	CC
cord-006229-7yoilsho	5839	44	testing	testing	NN
cord-006229-7yoilsho	5839	45	costs	cost	NNS
cord-006229-7yoilsho	5839	46	.	.	.
cord-006229-7yoilsho	5840	1	The	the	DT
cord-006229-7yoilsho	5840	2	'	'	``
cord-006229-7yoilsho	5840	3	value	value	NN
cord-006229-7yoilsho	5840	4	'	'	''
cord-006229-7yoilsho	5840	5	of	of	IN
cord-006229-7yoilsho	5840	6	testing	testing	NN
cord-006229-7yoilsho	5840	7	is	be	VBZ
cord-006229-7yoilsho	5840	8	defined	define	VBN
cord-006229-7yoilsho	5840	9	as	as	IN
cord-006229-7yoilsho	5840	10	the	the	DT
cord-006229-7yoilsho	5840	11	expected	expect	VBN
cord-006229-7yoilsho	5840	12	social	social	JJ
cord-006229-7yoilsho	5840	13	net	net	JJ
cord-006229-7yoilsho	5840	14	benefit	benefit	NN
cord-006229-7yoilsho	5840	15	from	from	IN
cord-006229-7yoilsho	5840	16	decision	decision	NN
cord-006229-7yoilsho	5840	17	-	-	HYPH
cord-006229-7yoilsho	5840	18	making	making	NN
cord-006229-7yoilsho	5840	19	on	on	IN
cord-006229-7yoilsho	5840	20	the	the	DT
cord-006229-7yoilsho	5840	21	use	use	NN
cord-006229-7yoilsho	5840	22	of	of	IN
cord-006229-7yoilsho	5840	23	chemicals	chemical	NNS
cord-006229-7yoilsho	5840	24	with	with	IN
cord-006229-7yoilsho	5840	25	additional	additional	JJ
cord-006229-7yoilsho	5840	26	,	,	,
cord-006229-7yoilsho	5840	27	but	but	CC
cord-006229-7yoilsho	5840	28	uncertain	uncertain	JJ
cord-006229-7yoilsho	5840	29	information	information	NN
cord-006229-7yoilsho	5840	30	from	from	IN
cord-006229-7yoilsho	5840	31	testing	testing	NN
cord-006229-7yoilsho	5840	32	.	.	.
cord-006229-7yoilsho	5841	1	The	the	DT
cord-006229-7yoilsho	5841	2	VOI	VOI	NNP
cord-006229-7yoilsho	5841	3	is	be	VBZ
cord-006229-7yoilsho	5841	4	calculated	calculate	VBN
cord-006229-7yoilsho	5841	5	for	for	IN
cord-006229-7yoilsho	5841	6	a	a	DT
cord-006229-7yoilsho	5841	7	set	set	NN
cord-006229-7yoilsho	5841	8	of	of	IN
cord-006229-7yoilsho	5841	9	individual	individual	JJ
cord-006229-7yoilsho	5841	10	nonanimal	nonanimal	JJ
cord-006229-7yoilsho	5841	11	methods	method	NNS
cord-006229-7yoilsho	5841	12	including	include	VBG
cord-006229-7yoilsho	5841	13	DPRA	DPRA	NNP
cord-006229-7yoilsho	5841	14	,	,	,
cord-006229-7yoilsho	5841	15	OECD	OECD	NNP
cord-006229-7yoilsho	5841	16	QSAR	QSAR	NNP
cord-006229-7yoilsho	5841	17	Toolbox	Toolbox	NNP
cord-006229-7yoilsho	5841	18	,	,	,
cord-006229-7yoilsho	5841	19	ARE	are	VBP
cord-006229-7yoilsho	5841	20	-	-	:
cord-006229-7yoilsho	5841	21	Nrf2	nrf2	JJ
cord-006229-7yoilsho	5841	22	luciferase	luciferase	NN
cord-006229-7yoilsho	5841	23	method	method	NN
cord-006229-7yoilsho	5841	24	covered	cover	VBN
cord-006229-7yoilsho	5841	25	by	by	IN
cord-006229-7yoilsho	5841	26	KeratinoSens	KeratinoSens	NNP
cord-006229-7yoilsho	5841	27	and	and	CC
cord-006229-7yoilsho	5841	28	LuSens	LuSens	NNP
cord-006229-7yoilsho	5841	29	,	,	,
cord-006229-7yoilsho	5841	30	and	and	CC
cord-006229-7yoilsho	5841	31	hCLAT	hclat	RB
cord-006229-7yoilsho	5841	32	,	,	,
cord-006229-7yoilsho	5841	33	seven	seven	CD
cord-006229-7yoilsho	5841	34	battery	battery	NN
cord-006229-7yoilsho	5841	35	combinations	combination	NNS
cord-006229-7yoilsho	5841	36	of	of	IN
cord-006229-7yoilsho	5841	37	these	these	DT
cord-006229-7yoilsho	5841	38	methods	method	NNS
cord-006229-7yoilsho	5841	39	,	,	,
cord-006229-7yoilsho	5841	40	and	and	CC
cord-006229-7yoilsho	5841	41	86	86	CD
cord-006229-7yoilsho	5841	42	two	two	CD
cord-006229-7yoilsho	5841	43	-	-	HYPH
cord-006229-7yoilsho	5841	44	test	test	NN
cord-006229-7yoilsho	5841	45	and	and	CC
cord-006229-7yoilsho	5841	46	360	360	CD
cord-006229-7yoilsho	5841	47	three	three	CD
cord-006229-7yoilsho	5841	48	-	-	HYPH
cord-006229-7yoilsho	5841	49	tests	test	NNS
cord-006229-7yoilsho	5841	50	sequential	sequential	JJ
cord-006229-7yoilsho	5841	51	strategies	strategy	NNS
cord-006229-7yoilsho	5841	52	consisting	consist	VBG
cord-006229-7yoilsho	5841	53	of	of	IN
cord-006229-7yoilsho	5841	54	nonanimal	nonanimal	JJ
cord-006229-7yoilsho	5841	55	methods	method	NNS
cord-006229-7yoilsho	5841	56	.	.	.
cord-006229-7yoilsho	5842	1	Their	-PRON-	PRP$
cord-006229-7yoilsho	5842	2	VOI	VOI	NNP
cord-006229-7yoilsho	5842	3	is	be	VBZ
cord-006229-7yoilsho	5842	4	compared	compare	VBN
cord-006229-7yoilsho	5842	5	to	to	IN
cord-006229-7yoilsho	5842	6	the	the	DT
cord-006229-7yoilsho	5842	7	VOI	VOI	NNP
cord-006229-7yoilsho	5842	8	of	of	IN
cord-006229-7yoilsho	5842	9	the	the	DT
cord-006229-7yoilsho	5842	10	local	local	JJ
cord-006229-7yoilsho	5842	11	lymph	lymph	NN
cord-006229-7yoilsho	5842	12	node	node	NN
cord-006229-7yoilsho	5842	13	assay	assay	NN
cord-006229-7yoilsho	5842	14	(	(	-LRB-
cord-006229-7yoilsho	5842	15	LLNA	LLNA	NNP
cord-006229-7yoilsho	5842	16	)	)	-RRB-
cord-006229-7yoilsho	5842	17	as	as	IN
cord-006229-7yoilsho	5842	18	the	the	DT
cord-006229-7yoilsho	5842	19	animal	animal	NN
cord-006229-7yoilsho	5842	20	test	test	NN
cord-006229-7yoilsho	5842	21	.	.	.
cord-006229-7yoilsho	5843	1	We	-PRON-	PRP
cord-006229-7yoilsho	5843	2	find	find	VBP
cord-006229-7yoilsho	5843	3	that	that	IN
cord-006229-7yoilsho	5843	4	battery	battery	NN
cord-006229-7yoilsho	5843	5	and	and	CC
cord-006229-7yoilsho	5843	6	sequential	sequential	JJ
cord-006229-7yoilsho	5843	7	combinations	combination	NNS
cord-006229-7yoilsho	5843	8	of	of	IN
cord-006229-7yoilsho	5843	9	nonanimal	nonanimal	JJ
cord-006229-7yoilsho	5843	10	methods	method	NNS
cord-006229-7yoilsho	5843	11	reveal	reveal	VBP
cord-006229-7yoilsho	5843	12	a	a	DT
cord-006229-7yoilsho	5843	13	higher	high	JJR
cord-006229-7yoilsho	5843	14	VOI	VOI	NNP
cord-006229-7yoilsho	5843	15	than	than	IN
cord-006229-7yoilsho	5843	16	the	the	DT
cord-006229-7yoilsho	5843	17	LLNA	LLNA	NNP
cord-006229-7yoilsho	5843	18	.	.	.
cord-006229-7yoilsho	5844	1	In	in	IN
cord-006229-7yoilsho	5844	2	particular	particular	JJ
cord-006229-7yoilsho	5844	3	,	,	,
cord-006229-7yoilsho	5844	4	for	for	IN
cord-006229-7yoilsho	5844	5	small	small	JJ
cord-006229-7yoilsho	5844	6	prior	prior	JJ
cord-006229-7yoilsho	5844	7	beliefs	belief	NNS
cord-006229-7yoilsho	5844	8	(	(	-LRB-
cord-006229-7yoilsho	5844	9	i.e.	i.e.	FW
cord-006229-7yoilsho	5844	10	a	a	DT
cord-006229-7yoilsho	5844	11	chemicals	chemical	NNS
cord-006229-7yoilsho	5844	12	is	be	VBZ
cord-006229-7yoilsho	5844	13	,	,	,
cord-006229-7yoilsho	5844	14	prior	prior	RB
cord-006229-7yoilsho	5844	15	to	to	IN
cord-006229-7yoilsho	5844	16	testing	testing	NN
cord-006229-7yoilsho	5844	17	,	,	,
cord-006229-7yoilsho	5844	18	assumed	assume	VBD
cord-006229-7yoilsho	5844	19	to	to	TO
cord-006229-7yoilsho	5844	20	be	be	VB
cord-006229-7yoilsho	5844	21	a	a	DT
cord-006229-7yoilsho	5844	22	non	non	JJ
cord-006229-7yoilsho	5844	23	-	-	JJ
cord-006229-7yoilsho	5844	24	sensitiser	sensitiser	JJ
cord-006229-7yoilsho	5844	25	)	)	-RRB-
cord-006229-7yoilsho	5844	26	,	,	,
cord-006229-7yoilsho	5844	27	a	a	DT
cord-006229-7yoilsho	5844	28	battery	battery	NN
cord-006229-7yoilsho	5844	29	of	of	IN
cord-006229-7yoilsho	5844	30	DPRA	DPRA	NNP
cord-006229-7yoilsho	5844	31	+	+	CC
cord-006229-7yoilsho	5844	32	LuSens	LuSens	NNP
cord-006229-7yoilsho	5844	33	reveals	reveal	VBZ
cord-006229-7yoilsho	5844	34	the	the	DT
cord-006229-7yoilsho	5844	35	highest	high	JJS
cord-006229-7yoilsho	5844	36	VOI	VOI	NNP
cord-006229-7yoilsho	5844	37	.	.	.
cord-006229-7yoilsho	5845	1	If	if	IN
cord-006229-7yoilsho	5845	2	there	there	EX
cord-006229-7yoilsho	5845	3	are	be	VBP
cord-006229-7yoilsho	5845	4	strong	strong	JJ
cord-006229-7yoilsho	5845	5	beliefs	belief	NNS
cord-006229-7yoilsho	5845	6	that	that	WDT
cord-006229-7yoilsho	5845	7	a	a	DT
cord-006229-7yoilsho	5845	8	chemical	chemical	NN
cord-006229-7yoilsho	5845	9	is	be	VBZ
cord-006229-7yoilsho	5845	10	a	a	DT
cord-006229-7yoilsho	5845	11	sensitizer	sensitizer	NN
cord-006229-7yoilsho	5845	12	,	,	,
cord-006229-7yoilsho	5845	13	a	a	DT
cord-006229-7yoilsho	5845	14	sequential	sequential	JJ
cord-006229-7yoilsho	5845	15	combination	combination	NN
cord-006229-7yoilsho	5845	16	of	of	IN
cord-006229-7yoilsho	5845	17	the	the	DT
cord-006229-7yoilsho	5845	18	battery	battery	NN
cord-006229-7yoilsho	5845	19	DPRA	DPRA	NNP
cord-006229-7yoilsho	5845	20	+	+	CC
cord-006229-7yoilsho	5845	21	LuSens	LuSens	NNP
cord-006229-7yoilsho	5845	22	,	,	,
cord-006229-7yoilsho	5845	23	followed	follow	VBN
cord-006229-7yoilsho	5845	24	by	by	IN
cord-006229-7yoilsho	5845	25	KeratinoSens	KeratinoSens	NNP
cord-006229-7yoilsho	5845	26	+	+	CC
cord-006229-7yoilsho	5845	27	hCLAT	hclat	RB
cord-006229-7yoilsho	5845	28	at	at	IN
cord-006229-7yoilsho	5845	29	the	the	DT
cord-006229-7yoilsho	5845	30	second	second	JJ
cord-006229-7yoilsho	5845	31	stage	stage	NN
cord-006229-7yoilsho	5845	32	and	and	CC
cord-006229-7yoilsho	5845	33	by	by	IN
cord-006229-7yoilsho	5845	34	the	the	DT
cord-006229-7yoilsho	5845	35	OECD	OECD	NNP
cord-006229-7yoilsho	5845	36	QSAR	QSAR	NNP
cord-006229-7yoilsho	5845	37	toolbox	toolbox	NN
cord-006229-7yoilsho	5845	38	at	at	IN
cord-006229-7yoilsho	5845	39	the	the	DT
cord-006229-7yoilsho	5845	40	third	third	JJ
cord-006229-7yoilsho	5845	41	stage	stage	NN
cord-006229-7yoilsho	5845	42	performs	perform	VBZ
cord-006229-7yoilsho	5845	43	best	best	RB
cord-006229-7yoilsho	5845	44	.	.	.
cord-006229-7yoilsho	5846	1	For	for	IN
cord-006229-7yoilsho	5846	2	given	give	VBN
cord-006229-7yoilsho	5846	3	specifications	specification	NNS
cord-006229-7yoilsho	5846	4	of	of	IN
cord-006229-7yoilsho	5846	5	expected	expect	VBN
cord-006229-7yoilsho	5846	6	payoffs	payoff	NNS
cord-006229-7yoilsho	5846	7	the	the	DT
cord-006229-7yoilsho	5846	8	VOI	VOI	NNP
cord-006229-7yoilsho	5846	9	of	of	IN
cord-006229-7yoilsho	5846	10	the	the	DT
cord-006229-7yoilsho	5846	11	nonanimal	nonanimal	NNP
cord-006229-7yoilsho	5846	12	strategy	strategy	NN
cord-006229-7yoilsho	5846	13	significantly	significantly	RB
cord-006229-7yoilsho	5846	14	outperformed	outperform	VBD
cord-006229-7yoilsho	5846	15	the	the	DT
cord-006229-7yoilsho	5846	16	VOI	VOI	NNP
cord-006229-7yoilsho	5846	17	of	of	IN
cord-006229-7yoilsho	5846	18	the	the	DT
cord-006229-7yoilsho	5846	19	LLNA	LLNA	NNP
cord-006229-7yoilsho	5846	20	,	,	,
cord-006229-7yoilsho	5846	21	for	for	IN
cord-006229-7yoilsho	5846	22	the	the	DT
cord-006229-7yoilsho	5846	23	entire	entire	JJ
cord-006229-7yoilsho	5846	24	range	range	NN
cord-006229-7yoilsho	5846	25	of	of	IN
cord-006229-7yoilsho	5846	26	prior	prior	JJ
cord-006229-7yoilsho	5846	27	beliefs	belief	NNS
cord-006229-7yoilsho	5846	28	.	.	.
cord-006229-7yoilsho	5847	1	This	this	DT
cord-006229-7yoilsho	5847	2	underlines	underline	VBZ
cord-006229-7yoilsho	5847	3	strong	strong	JJ
cord-006229-7yoilsho	5847	4	economic	economic	JJ
cord-006229-7yoilsho	5847	5	potential	potential	NN
cord-006229-7yoilsho	5847	6	of	of	IN
cord-006229-7yoilsho	5847	7	non	non	JJ
cord-006229-7yoilsho	5847	8	-	-	JJ
cord-006229-7yoilsho	5847	9	animal	animal	JJ
cord-006229-7yoilsho	5847	10	methods	method	NNS
cord-006229-7yoilsho	5847	11	for	for	IN
cord-006229-7yoilsho	5847	12	skin	skin	NN
cord-006229-7yoilsho	5847	13	sensitization	sensitization	NN
cord-006229-7yoilsho	5847	14	assessment	assessment	NN
cord-006229-7yoilsho	5847	15	.	.	.
cord-006229-7yoilsho	5848	1	a	a	DT
cord-006229-7yoilsho	5848	2	chemical	chemical	JJ
cord-006229-7yoilsho	5848	3	series	series	NN
cord-006229-7yoilsho	5848	4	to	to	TO
cord-006229-7yoilsho	5848	5	predict	predict	VB
cord-006229-7yoilsho	5848	6	the	the	DT
cord-006229-7yoilsho	5848	7	proarrhythmic	proarrhythmic	JJ
cord-006229-7yoilsho	5848	8	potential	potential	NN
cord-006229-7yoilsho	5848	9	of	of	IN
cord-006229-7yoilsho	5848	10	drugs	drug	NNS
cord-006229-7yoilsho	5848	11	with	with	IN
cord-006229-7yoilsho	5848	12	low	low	JJ
cord-006229-7yoilsho	5848	13	solubility	solubility	NN
cord-006229-7yoilsho	5848	14	for	for	IN
cord-006229-7yoilsho	5848	15	which	which	WDT
cord-006229-7yoilsho	5848	16	no	no	DT
cord-006229-7yoilsho	5848	17	reliable	reliable	JJ
cord-006229-7yoilsho	5848	18	Purkinje	Purkinje	NNP
cord-006229-7yoilsho	5848	19	fiber	fiber	NN
cord-006229-7yoilsho	5848	20	results	result	NNS
cord-006229-7yoilsho	5848	21	could	could	MD
cord-006229-7yoilsho	5848	22	be	be	VB
cord-006229-7yoilsho	5848	23	obtained	obtain	VBN
cord-006229-7yoilsho	5848	24	.	.	.
cord-006229-7yoilsho	5849	1	These	these	DT
cord-006229-7yoilsho	5849	2	validation	validation	NN
cord-006229-7yoilsho	5849	3	results	result	NNS
cord-006229-7yoilsho	5849	4	showed	show	VBD
cord-006229-7yoilsho	5849	5	that	that	IN
cord-006229-7yoilsho	5849	6	this	this	DT
cord-006229-7yoilsho	5849	7	cardiosafety	cardiosafety	NN
cord-006229-7yoilsho	5849	8	in	in	IN
cord-006229-7yoilsho	5849	9	silico	silico	NN
cord-006229-7yoilsho	5849	10	model	model	NN
cord-006229-7yoilsho	5849	11	can	can	MD
cord-006229-7yoilsho	5849	12	successfully	successfully	RB
cord-006229-7yoilsho	5849	13	be	be	VB
cord-006229-7yoilsho	5849	14	applied	apply	VBN
cord-006229-7yoilsho	5849	15	in	in	IN
cord-006229-7yoilsho	5849	16	R&D	r&d	NN
cord-006229-7yoilsho	5849	17	to	to	TO
cord-006229-7yoilsho	5849	18	predict	predict	VB
cord-006229-7yoilsho	5849	19	the	the	DT
cord-006229-7yoilsho	5849	20	proarrhythmic	proarrhythmic	JJ
cord-006229-7yoilsho	5849	21	potential	potential	NN
cord-006229-7yoilsho	5849	22	of	of	IN
cord-006229-7yoilsho	5849	23	drug	drug	NN
cord-006229-7yoilsho	5849	24	candidates	candidate	NNS
cord-006229-7yoilsho	5849	25	within	within	IN
cord-006229-7yoilsho	5849	26	the	the	DT
cord-006229-7yoilsho	5849	27	model	model	NN
cord-006229-7yoilsho	5849	28	AD	ad	NN
cord-006229-7yoilsho	5849	29	.	.	.
cord-006229-7yoilsho	5850	1	Introduction	introduction	NN
cord-006229-7yoilsho	5850	2	:	:	:
cord-006229-7yoilsho	5851	1	The	the	DT
cord-006229-7yoilsho	5851	2	use	use	NN
cord-006229-7yoilsho	5851	3	of	of	IN
cord-006229-7yoilsho	5851	4	p	p	NN
cord-006229-7yoilsho	5851	5	-	-	HYPH
cord-006229-7yoilsho	5851	6	phenylenediamine	phenylenediamine	NN
cord-006229-7yoilsho	5851	7	(	(	-LRB-
cord-006229-7yoilsho	5851	8	PPD	PPD	NNP
cord-006229-7yoilsho	5851	9	)	)	-RRB-
cord-006229-7yoilsho	5851	10	and	and	CC
cord-006229-7yoilsho	5851	11	derivatives	derivative	NNS
cord-006229-7yoilsho	5851	12	(	(	-LRB-
cord-006229-7yoilsho	5851	13	Tab	Tab	NNP
cord-006229-7yoilsho	5851	14	.	.	.
cord-006229-7yoilsho	5851	15	1	1	LS
cord-006229-7yoilsho	5851	16	)	)	-RRB-
cord-006229-7yoilsho	5851	17	in	in	IN
cord-006229-7yoilsho	5851	18	oxidative	oxidative	JJ
cord-006229-7yoilsho	5851	19	consumer	consumer	NN
cord-006229-7yoilsho	5851	20	hair	hair	NN
cord-006229-7yoilsho	5851	21	dye	dye	NN
cord-006229-7yoilsho	5851	22	products	product	NNS
cord-006229-7yoilsho	5851	23	is	be	VBZ
cord-006229-7yoilsho	5851	24	considered	consider	VBN
cord-006229-7yoilsho	5851	25	as	as	IN
cord-006229-7yoilsho	5851	26	key	key	JJ
cord-006229-7yoilsho	5851	27	in	in	IN
cord-006229-7yoilsho	5851	28	hair	hair	NN
cord-006229-7yoilsho	5851	29	dye	dye	NN
cord-006229-7yoilsho	5851	30	allergic	allergic	JJ
cord-006229-7yoilsho	5851	31	contact	contact	NN
cord-006229-7yoilsho	5851	32	dermatitis	dermatitis	NN
cord-006229-7yoilsho	5851	33	[	[	-LRB-
cord-006229-7yoilsho	5851	34	1	1	CD
cord-006229-7yoilsho	5851	35	]	]	-RRB-
cord-006229-7yoilsho	5851	36	[	[	-LRB-
cord-006229-7yoilsho	5851	37	2	2	CD
cord-006229-7yoilsho	5851	38	]	]	-RRB-
cord-006229-7yoilsho	5851	39	[	[	-LRB-
cord-006229-7yoilsho	5851	40	3	3	CD
cord-006229-7yoilsho	5851	41	]	]	-RRB-
cord-006229-7yoilsho	5851	42	[	[	-LRB-
cord-006229-7yoilsho	5851	43	4	4	CD
cord-006229-7yoilsho	5851	44	]	]	-RRB-
cord-006229-7yoilsho	5851	45	.	.	.
cord-006229-7yoilsho	5852	1	In	in	IN
cord-006229-7yoilsho	5852	2	recent	recent	JJ
cord-006229-7yoilsho	5852	3	supplement	supplement	NN
cord-006229-7yoilsho	5852	4	,	,	,
cord-006229-7yoilsho	5852	5	2-methoxymethyl	2-methoxymethyl	CD
cord-006229-7yoilsho	5852	6	-	-	HYPH
cord-006229-7yoilsho	5852	7	PPD	PPD	NNP
cord-006229-7yoilsho	5852	8	(	(	-LRB-
cord-006229-7yoilsho	5852	9	ME+	ME+	NNP
cord-006229-7yoilsho	5852	10	)	)	-RRB-
cord-006229-7yoilsho	5852	11	shows	show	VBZ
cord-006229-7yoilsho	5852	12	significantly	significantly	RB
cord-006229-7yoilsho	5852	13	reduced	reduce	VBN
cord-006229-7yoilsho	5852	14	sensitizing	sensitizing	NN
cord-006229-7yoilsho	5852	15	properties	property	NNS
cord-006229-7yoilsho	5852	16	[	[	-LRB-
cord-006229-7yoilsho	5852	17	5	5	CD
cord-006229-7yoilsho	5852	18	,	,	,
cord-006229-7yoilsho	5852	19	6	6	CD
cord-006229-7yoilsho	5852	20	]	]	-RRB-
cord-006229-7yoilsho	5852	21	.	.	.
cord-006229-7yoilsho	5853	1	Since	since	IN
cord-006229-7yoilsho	5853	2	overcoming	overcome	VBG
cord-006229-7yoilsho	5853	3	the	the	DT
cord-006229-7yoilsho	5853	4	skin	skin	NN
cord-006229-7yoilsho	5853	5	barrier	barrier	NN
cord-006229-7yoilsho	5853	6	is	be	VBZ
cord-006229-7yoilsho	5853	7	a	a	DT
cord-006229-7yoilsho	5853	8	prerequisite	prerequisite	NN
cord-006229-7yoilsho	5853	9	for	for	IN
cord-006229-7yoilsho	5853	10	sensitization	sensitization	NN
cord-006229-7yoilsho	5853	11	,	,	,
cord-006229-7yoilsho	5853	12	numerous	numerous	JJ
cord-006229-7yoilsho	5853	13	in	in	IN
cord-006229-7yoilsho	5853	14	vitro	vitro	FW
cord-006229-7yoilsho	5853	15	an	an	DT
cord-006229-7yoilsho	5853	16	in	in	IN
cord-006229-7yoilsho	5853	17	vivo	vivo	NN
cord-006229-7yoilsho	5853	18	studies	study	NNS
cord-006229-7yoilsho	5853	19	on	on	IN
cord-006229-7yoilsho	5853	20	skin	skin	NN
cord-006229-7yoilsho	5853	21	penetration	penetration	NN
cord-006229-7yoilsho	5853	22	of	of	IN
cord-006229-7yoilsho	5853	23	PPD	PPD	NNP
cord-006229-7yoilsho	5853	24	and	and	CC
cord-006229-7yoilsho	5853	25	derivatives	derivative	NNS
cord-006229-7yoilsho	5853	26	have	have	VBP
cord-006229-7yoilsho	5853	27	been	be	VBN
cord-006229-7yoilsho	5853	28	performed	perform	VBN
cord-006229-7yoilsho	5853	29	.	.	.
cord-006229-7yoilsho	5854	1	The	the	DT
cord-006229-7yoilsho	5854	2	aim	aim	NN
cord-006229-7yoilsho	5854	3	of	of	IN
cord-006229-7yoilsho	5854	4	the	the	DT
cord-006229-7yoilsho	5854	5	present	present	JJ
cord-006229-7yoilsho	5854	6	study	study	NN
cord-006229-7yoilsho	5854	7	is	be	VBZ
cord-006229-7yoilsho	5854	8	the	the	DT
cord-006229-7yoilsho	5854	9	in	in	IN
cord-006229-7yoilsho	5854	10	silico	silico	NN
cord-006229-7yoilsho	5854	11	prediction	prediction	NN
cord-006229-7yoilsho	5854	12	of	of	IN
cord-006229-7yoilsho	5854	13	the	the	DT
cord-006229-7yoilsho	5854	14	penetration	penetration	NN
cord-006229-7yoilsho	5854	15	of	of	IN
cord-006229-7yoilsho	5854	16	PPDs	ppd	NNS
cord-006229-7yoilsho	5854	17	,	,	,
cord-006229-7yoilsho	5854	18	because	because	IN
cord-006229-7yoilsho	5854	19	such	such	JJ
cord-006229-7yoilsho	5854	20	computations	computation	NNS
cord-006229-7yoilsho	5854	21	may	may	MD
cord-006229-7yoilsho	5854	22	help	help	VB
cord-006229-7yoilsho	5854	23	in	in	IN
cord-006229-7yoilsho	5854	24	understanding	understand	VBG
cord-006229-7yoilsho	5854	25	the	the	DT
cord-006229-7yoilsho	5854	26	processes	process	NNS
cord-006229-7yoilsho	5854	27	involved	involve	VBN
cord-006229-7yoilsho	5854	28	in	in	IN
cord-006229-7yoilsho	5854	29	sensitization	sensitization	NN
cord-006229-7yoilsho	5854	30	.	.	.
cord-006229-7yoilsho	5855	1	For	for	IN
cord-006229-7yoilsho	5855	2	the	the	DT
cord-006229-7yoilsho	5855	3	first	first	JJ
cord-006229-7yoilsho	5855	4	time	time	NN
cord-006229-7yoilsho	5855	5	,	,	,
cord-006229-7yoilsho	5855	6	software	software	NN
cord-006229-7yoilsho	5855	7	DSkin	dskin	XX
cord-006229-7yoilsho	5855	8	[	[	-LRB-
cord-006229-7yoilsho	5855	9	7	7	CD
cord-006229-7yoilsho	5855	10	]	]	-RRB-
cord-006229-7yoilsho	5855	11	is	be	VBZ
cord-006229-7yoilsho	5855	12	challenged	challenge	VBN
cord-006229-7yoilsho	5855	13	to	to	TO
cord-006229-7yoilsho	5855	14	simulate	simulate	VB
cord-006229-7yoilsho	5855	15	this	this	DT
cord-006229-7yoilsho	5855	16	class	class	NN
cord-006229-7yoilsho	5855	17	of	of	IN
cord-006229-7yoilsho	5855	18	compounds	compound	NNS
cord-006229-7yoilsho	5855	19	.	.	.
cord-006229-7yoilsho	5856	1	In	in	IN
cord-006229-7yoilsho	5856	2	silico	silico	NN
cord-006229-7yoilsho	5856	3	results	result	NNS
cord-006229-7yoilsho	5856	4	are	be	VBP
cord-006229-7yoilsho	5856	5	retrospectively	retrospectively	RB
cord-006229-7yoilsho	5856	6	compared	compare	VBN
cord-006229-7yoilsho	5856	7	to	to	IN
cord-006229-7yoilsho	5856	8	previously	previously	RB
cord-006229-7yoilsho	5856	9	published	publish	VBN
cord-006229-7yoilsho	5856	10	experimental	experimental	JJ
cord-006229-7yoilsho	5856	11	data	datum	NNS
cord-006229-7yoilsho	5856	12	and	and	CC
cord-006229-7yoilsho	5856	13	may	may	MD
cord-006229-7yoilsho	5856	14	assist	assist	VB
cord-006229-7yoilsho	5856	15	in	in	IN
cord-006229-7yoilsho	5856	16	future	future	JJ
cord-006229-7yoilsho	5856	17	tailoring	tailoring	NN
cord-006229-7yoilsho	5856	18	of	of	IN
cord-006229-7yoilsho	5856	19	in	in	FW
cord-006229-7yoilsho	5856	20	vitro	vitro	FW
cord-006229-7yoilsho	5856	21	experiments	experiment	NNS
cord-006229-7yoilsho	5856	22	.	.	.
cord-006229-7yoilsho	5857	1	Material	material	NN
cord-006229-7yoilsho	5857	2	and	and	CC
cord-006229-7yoilsho	5857	3	Methods	Methods	NNPS
cord-006229-7yoilsho	5857	4	:	:	:
cord-006229-7yoilsho	5857	5	The	the	DT
cord-006229-7yoilsho	5857	6	permeabilities	permeability	NNS
cord-006229-7yoilsho	5857	7	,	,	,
cord-006229-7yoilsho	5857	8	lag	lag	NN
cord-006229-7yoilsho	5857	9	-	-	HYPH
cord-006229-7yoilsho	5857	10	times	time	NNS
cord-006229-7yoilsho	5857	11	and	and	CC
cord-006229-7yoilsho	5857	12	the	the	DT
cord-006229-7yoilsho	5857	13	time	time	NN
cord-006229-7yoilsho	5857	14	-	-	HYPH
cord-006229-7yoilsho	5857	15	dependent	dependent	JJ
cord-006229-7yoilsho	5857	16	accumulated	accumulate	VBN
cord-006229-7yoilsho	5857	17	amounts	amount	NNS
cord-006229-7yoilsho	5857	18	of	of	IN
cord-006229-7yoilsho	5857	19	PPDs	ppd	NNS
cord-006229-7yoilsho	5857	20	were	be	VBD
cord-006229-7yoilsho	5857	21	computed	compute	VBN
cord-006229-7yoilsho	5857	22	using	use	VBG
cord-006229-7yoilsho	5857	23	DSkin	dskin	PRP
cord-006229-7yoilsho	5857	24	.	.	.
cord-006229-7yoilsho	5858	1	Input	input	NN
cord-006229-7yoilsho	5858	2	parameters	parameter	NNS
cord-006229-7yoilsho	5858	3	for	for	IN
cord-006229-7yoilsho	5858	4	the	the	DT
cord-006229-7yoilsho	5858	5	latter	latter	JJ
cord-006229-7yoilsho	5858	6	were	be	VBD
cord-006229-7yoilsho	5858	7	a	a	DT
cord-006229-7yoilsho	5858	8	concentration	concentration	NN
cord-006229-7yoilsho	5858	9	of	of	IN
cord-006229-7yoilsho	5858	10	1	1	CD
cord-006229-7yoilsho	5858	11	mg	mg	NNP
cord-006229-7yoilsho	5858	12	/	/	SYM
cord-006229-7yoilsho	5858	13	mL	ml	NN
cord-006229-7yoilsho	5858	14	(	(	-LRB-
cord-006229-7yoilsho	5858	15	1	1	CD
cord-006229-7yoilsho	5858	16	%	%	NN
cord-006229-7yoilsho	5858	17	)	)	-RRB-
cord-006229-7yoilsho	5858	18	,	,	,
cord-006229-7yoilsho	5858	19	finite	finite	JJ
cord-006229-7yoilsho	5858	20	dosing	dosing	NN
cord-006229-7yoilsho	5858	21	and	and	CC
cord-006229-7yoilsho	5858	22	30	30	CD
cord-006229-7yoilsho	5858	23	min	min	NN
cord-006229-7yoilsho	5858	24	in	in	IN
cord-006229-7yoilsho	5858	25	use	use	NN
cord-006229-7yoilsho	5858	26	incubation	incubation	NN
cord-006229-7yoilsho	5858	27	periods	period	NNS
cord-006229-7yoilsho	5858	28	.	.	.
cord-006229-7yoilsho	5859	1	Molecular	molecular	JJ
cord-006229-7yoilsho	5859	2	structures	structure	NNS
cord-006229-7yoilsho	5859	3	were	be	VBD
cord-006229-7yoilsho	5859	4	optimized	optimize	VBN
cord-006229-7yoilsho	5859	5	ab	ab	FW
cord-006229-7yoilsho	5859	6	initio	initio	NNP
cord-006229-7yoilsho	5859	7	and	and	CC
cord-006229-7yoilsho	5859	8	the	the	DT
cord-006229-7yoilsho	5859	9	condensed	condense	VBN
cord-006229-7yoilsho	5859	10	Fukui	Fukui	NNP
cord-006229-7yoilsho	5859	11	functions	function	NNS
cord-006229-7yoilsho	5859	12	(	(	-LRB-
cord-006229-7yoilsho	5859	13	FF	FF	NNP
cord-006229-7yoilsho	5859	14	)	)	-RRB-
cord-006229-7yoilsho	5859	15	were	be	VBD
cord-006229-7yoilsho	5859	16	estimated	estimate	VBN
cord-006229-7yoilsho	5859	17	from	from	IN
cord-006229-7yoilsho	5859	18	Mulliken	Mulliken	NNP
cord-006229-7yoilsho	5859	19	population	population	NN
cord-006229-7yoilsho	5859	20	analyses	analysis	NNS
cord-006229-7yoilsho	5859	21	[	[	-LRB-
cord-006229-7yoilsho	5859	22	8	8	CD
cord-006229-7yoilsho	5859	23	]	]	-RRB-
cord-006229-7yoilsho	5859	24	and	and	CC
cord-006229-7yoilsho	5859	25	electrostatic	electrostatic	JJ
cord-006229-7yoilsho	5859	26	potentials	potential	NNS
cord-006229-7yoilsho	5859	27	using	use	VBG
cord-006229-7yoilsho	5859	28	GAMESS	GAMESS	NNP
cord-006229-7yoilsho	5859	29	[	[	-LRB-
cord-006229-7yoilsho	5859	30	9	9	CD
cord-006229-7yoilsho	5859	31	]	]	-RRB-
cord-006229-7yoilsho	5859	32	.	.	.
cord-006229-7yoilsho	5860	1	Results	result	NNS
cord-006229-7yoilsho	5860	2	:	:	:
cord-006229-7yoilsho	5861	1	Initial	initial	JJ
cord-006229-7yoilsho	5861	2	results	result	NNS
cord-006229-7yoilsho	5861	3	agree	agree	VBP
cord-006229-7yoilsho	5861	4	with	with	IN
cord-006229-7yoilsho	5861	5	experimental	experimental	JJ
cord-006229-7yoilsho	5861	6	results	result	NNS
cord-006229-7yoilsho	5861	7	using	use	VBG
cord-006229-7yoilsho	5861	8	PPD	PPD	NNP
cord-006229-7yoilsho	5861	9	in	in	IN
cord-006229-7yoilsho	5861	10	white	white	JJ
cord-006229-7yoilsho	5861	11	petrolatum	petrolatum	NN
cord-006229-7yoilsho	5861	12	,	,	,
cord-006229-7yoilsho	5861	13	demonstrating	demonstrate	VBG
cord-006229-7yoilsho	5861	14	the	the	DT
cord-006229-7yoilsho	5861	15	applicability	applicability	NN
cord-006229-7yoilsho	5861	16	of	of	IN
cord-006229-7yoilsho	5861	17	DSkin	DSkin	NNP
cord-006229-7yoilsho	5861	18	to	to	IN
cord-006229-7yoilsho	5861	19	PPDs	ppd	NNS
cord-006229-7yoilsho	5861	20	.	.	.
cord-006229-7yoilsho	5862	1	The	the	DT
cord-006229-7yoilsho	5862	2	four	four	CD
cord-006229-7yoilsho	5862	3	PPDs	ppd	NNS
cord-006229-7yoilsho	5862	4	exhibit	exhibit	VBP
cord-006229-7yoilsho	5862	5	only	only	RB
cord-006229-7yoilsho	5862	6	small	small	JJ
cord-006229-7yoilsho	5862	7	differences	difference	NNS
cord-006229-7yoilsho	5862	8	in	in	IN
cord-006229-7yoilsho	5862	9	permeabilities	permeability	NNS
cord-006229-7yoilsho	5862	10	in	in	IN
cord-006229-7yoilsho	5862	11	silico	silico	NNS
cord-006229-7yoilsho	5862	12	(	(	-LRB-
cord-006229-7yoilsho	5862	13	Tab	Tab	NNP
cord-006229-7yoilsho	5862	14	.	.	.
cord-006229-7yoilsho	5862	15	1	1	CD
cord-006229-7yoilsho	5862	16	)	)	-RRB-
cord-006229-7yoilsho	5862	17	.	.	.
cord-006229-7yoilsho	5863	1	Toluene-2,5-diamine	toluene-2,5-diamine	NN
cord-006229-7yoilsho	5863	2	shows	show	VBZ
cord-006229-7yoilsho	5863	3	a	a	DT
cord-006229-7yoilsho	5863	4	higher	high	JJR
cord-006229-7yoilsho	5863	5	accumulated	accumulate	VBN
cord-006229-7yoilsho	5863	6	mass	mass	NN
cord-006229-7yoilsho	5863	7	due	due	JJ
cord-006229-7yoilsho	5863	8	to	to	IN
cord-006229-7yoilsho	5863	9	increased	increase	VBN
cord-006229-7yoilsho	5863	10	lipophilicity	lipophilicity	NN
cord-006229-7yoilsho	5863	11	(	(	-LRB-
cord-006229-7yoilsho	5863	12	Fig	Fig	NNP
cord-006229-7yoilsho	5863	13	.	.	.
cord-006229-7yoilsho	5863	14	1	1	CD
cord-006229-7yoilsho	5863	15	)	)	-RRB-
cord-006229-7yoilsho	5863	16	.	.	.
cord-006229-7yoilsho	5864	1	In	in	IN
cord-006229-7yoilsho	5864	2	general	general	JJ
cord-006229-7yoilsho	5864	3	,	,	,
cord-006229-7yoilsho	5864	4	the	the	DT
cord-006229-7yoilsho	5864	5	FF	FF	NNP
cord-006229-7yoilsho	5864	6	were	be	VBD
cord-006229-7yoilsho	5864	7	very	very	RB
cord-006229-7yoilsho	5864	8	similar	similar	JJ
cord-006229-7yoilsho	5864	9	for	for	IN
cord-006229-7yoilsho	5864	10	all	all	DT
cord-006229-7yoilsho	5864	11	PPDs	ppd	NNS
cord-006229-7yoilsho	5864	12	and	and	CC
cord-006229-7yoilsho	5864	13	indicated	indicate	VBD
cord-006229-7yoilsho	5864	14	that	that	IN
cord-006229-7yoilsho	5864	15	the	the	DT
cord-006229-7yoilsho	5864	16	N	n	CD
cord-006229-7yoilsho	5864	17	atoms	atom	NNS
cord-006229-7yoilsho	5864	18	would	would	MD
cord-006229-7yoilsho	5864	19	be	be	VB
cord-006229-7yoilsho	5864	20	the	the	DT
cord-006229-7yoilsho	5864	21	preferred	preferred	JJ
cord-006229-7yoilsho	5864	22	targets	target	NNS
cord-006229-7yoilsho	5864	23	for	for	IN
cord-006229-7yoilsho	5864	24	radical	radical	JJ
cord-006229-7yoilsho	5864	25	and	and	CC
cord-006229-7yoilsho	5864	26	electrophilic	electrophilic	JJ
cord-006229-7yoilsho	5864	27	attack	attack	NN
cord-006229-7yoilsho	5864	28	.	.	.
cord-006229-7yoilsho	5865	1	Discussion	Discussion	NNP
cord-006229-7yoilsho	5865	2	and	and	CC
cord-006229-7yoilsho	5865	3	Outlook	Outlook	NNP
cord-006229-7yoilsho	5865	4	:	:	:
cord-006229-7yoilsho	5865	5	In	in	IN
cord-006229-7yoilsho	5865	6	silico	silico	NN
cord-006229-7yoilsho	5865	7	methods	method	NNS
cord-006229-7yoilsho	5865	8	may	may	MD
cord-006229-7yoilsho	5865	9	be	be	VB
cord-006229-7yoilsho	5865	10	used	use	VBN
cord-006229-7yoilsho	5865	11	to	to	TO
cord-006229-7yoilsho	5865	12	model	model	VB
cord-006229-7yoilsho	5865	13	the	the	DT
cord-006229-7yoilsho	5865	14	permeation	permeation	NN
cord-006229-7yoilsho	5865	15	of	of	IN
cord-006229-7yoilsho	5865	16	PPDs	ppd	NNS
cord-006229-7yoilsho	5865	17	despite	despite	IN
cord-006229-7yoilsho	5865	18	their	-PRON-	PRP$
cord-006229-7yoilsho	5865	19	low	low	JJ
cord-006229-7yoilsho	5865	20	molecular	molecular	JJ
cord-006229-7yoilsho	5865	21	weight	weight	NN
cord-006229-7yoilsho	5865	22	and	and	CC
cord-006229-7yoilsho	5865	23	low	low	JJ
cord-006229-7yoilsho	5865	24	lipophilicity	lipophilicity	NN
cord-006229-7yoilsho	5865	25	.	.	.
cord-006229-7yoilsho	5866	1	The	the	DT
cord-006229-7yoilsho	5866	2	low	low	JJ
cord-006229-7yoilsho	5866	3	amounts	amount	NNS
cord-006229-7yoilsho	5866	4	of	of	IN
cord-006229-7yoilsho	5866	5	PPDs	ppd	NNS
cord-006229-7yoilsho	5866	6	under	under	IN
cord-006229-7yoilsho	5866	7	in	in	IN
cord-006229-7yoilsho	5866	8	use	use	NN
cord-006229-7yoilsho	5866	9	conditions	condition	NNS
cord-006229-7yoilsho	5866	10	result	result	VBP
cord-006229-7yoilsho	5866	11	from	from	IN
cord-006229-7yoilsho	5866	12	oxidative	oxidative	JJ
cord-006229-7yoilsho	5866	13	conditions	condition	NNS
cord-006229-7yoilsho	5866	14	.	.	.
cord-006229-7yoilsho	5867	1	Computed	compute	VBN
cord-006229-7yoilsho	5867	2	ME+	ME+	NNP
cord-006229-7yoilsho	5867	3	permeation	permeation	NN
cord-006229-7yoilsho	5867	4	was	be	VBD
cord-006229-7yoilsho	5867	5	not	not	RB
cord-006229-7yoilsho	5867	6	different	different	JJ
cord-006229-7yoilsho	5867	7	to	to	IN
cord-006229-7yoilsho	5867	8	other	other	JJ
cord-006229-7yoilsho	5867	9	PPDs	ppd	NNS
cord-006229-7yoilsho	5867	10	,	,	,
cord-006229-7yoilsho	5867	11	therefore	therefore	RB
cord-006229-7yoilsho	5867	12	other	other	JJ
cord-006229-7yoilsho	5867	13	properties	property	NNS
cord-006229-7yoilsho	5867	14	account	account	VBP
cord-006229-7yoilsho	5867	15	for	for	IN
cord-006229-7yoilsho	5867	16	the	the	DT
cord-006229-7yoilsho	5867	17	reduced	reduce	VBN
cord-006229-7yoilsho	5867	18	sensitization	sensitization	NN
cord-006229-7yoilsho	5867	19	potential	potential	NN
cord-006229-7yoilsho	5867	20	.	.	.
cord-006229-7yoilsho	5868	1	The	the	DT
cord-006229-7yoilsho	5868	2	very	very	RB
cord-006229-7yoilsho	5868	3	similar	similar	JJ
cord-006229-7yoilsho	5868	4	FF	ff	NN
cord-006229-7yoilsho	5868	5	values	value	NNS
cord-006229-7yoilsho	5868	6	hint	hint	VBP
cord-006229-7yoilsho	5868	7	at	at	IN
cord-006229-7yoilsho	5868	8	similar	similar	JJ
cord-006229-7yoilsho	5868	9	reaction	reaction	NN
cord-006229-7yoilsho	5868	10	pathways	pathway	NNS
cord-006229-7yoilsho	5868	11	.	.	.
cord-006229-7yoilsho	5869	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	5869	2	,	,	,
cord-006229-7yoilsho	5869	3	PPD	PPD	NNP
cord-006229-7yoilsho	5869	4	and	and	CC
cord-006229-7yoilsho	5869	5	its	-PRON-	PRP$
cord-006229-7yoilsho	5869	6	derivatives	derivative	NNS
cord-006229-7yoilsho	5869	7	are	be	VBP
cord-006229-7yoilsho	5869	8	prone	prone	JJ
cord-006229-7yoilsho	5869	9	to	to	IN
cord-006229-7yoilsho	5869	10	N	n	CD
cord-006229-7yoilsho	5869	11	-	-	HYPH
cord-006229-7yoilsho	5869	12	acetylation	acetylation	NN
cord-006229-7yoilsho	5869	13	in	in	IN
cord-006229-7yoilsho	5869	14	living	live	VBG
cord-006229-7yoilsho	5869	15	skin	skin	NN
cord-006229-7yoilsho	5869	16	resulting	result	VBG
cord-006229-7yoilsho	5869	17	in	in	IN
cord-006229-7yoilsho	5869	18	metabolites	metabolite	NNS
cord-006229-7yoilsho	5869	19	exhibiting	exhibit	VBG
cord-006229-7yoilsho	5869	20	higher	high	JJR
cord-006229-7yoilsho	5869	21	molecular	molecular	JJ
cord-006229-7yoilsho	5869	22	weight	weight	NN
cord-006229-7yoilsho	5869	23	and	and	CC
cord-006229-7yoilsho	5869	24	greater	great	JJR
cord-006229-7yoilsho	5869	25	lipophilicity	lipophilicity	NN
cord-006229-7yoilsho	5869	26	than	than	IN
cord-006229-7yoilsho	5869	27	the	the	DT
cord-006229-7yoilsho	5869	28	parent	parent	NN
cord-006229-7yoilsho	5869	29	compounds	compound	NNS
cord-006229-7yoilsho	5869	30	.	.	.
cord-006229-7yoilsho	5870	1	The	the	DT
cord-006229-7yoilsho	5870	2	effects	effect	NNS
cord-006229-7yoilsho	5870	3	of	of	IN
cord-006229-7yoilsho	5870	4	N	n	CD
cord-006229-7yoilsho	5870	5	-	-	HYPH
cord-006229-7yoilsho	5870	6	acetylation	acetylation	NN
cord-006229-7yoilsho	5870	7	and	and	CC
cord-006229-7yoilsho	5870	8	reactions	reaction	NNS
cord-006229-7yoilsho	5870	9	of	of	IN
cord-006229-7yoilsho	5870	10	PPD	PPD	NNP
cord-006229-7yoilsho	5870	11	and	and	CC
cord-006229-7yoilsho	5870	12	its	-PRON-	PRP$
cord-006229-7yoilsho	5870	13	derivatives	derivative	NNS
cord-006229-7yoilsho	5870	14	with	with	IN
cord-006229-7yoilsho	5870	15	histidine	histidine	NN
cord-006229-7yoilsho	5870	16	and	and	CC
cord-006229-7yoilsho	5870	17	cysteine	cysteine	NN
cord-006229-7yoilsho	5870	18	residues	residue	NNS
cord-006229-7yoilsho	5870	19	are	be	VBP
cord-006229-7yoilsho	5870	20	subject	subject	JJ
cord-006229-7yoilsho	5870	21	of	of	IN
cord-006229-7yoilsho	5870	22	upcoming	upcoming	JJ
cord-006229-7yoilsho	5870	23	computations	computation	NNS
cord-006229-7yoilsho	5870	24	.	.	.
cord-006229-7yoilsho	5871	1	Dermal	dermal	JJ
cord-006229-7yoilsho	5871	2	absorption	absorption	NN
cord-006229-7yoilsho	5871	3	is	be	VBZ
cord-006229-7yoilsho	5871	4	an	an	DT
cord-006229-7yoilsho	5871	5	important	important	JJ
cord-006229-7yoilsho	5871	6	factor	factor	NN
cord-006229-7yoilsho	5871	7	in	in	IN
cord-006229-7yoilsho	5871	8	regulatory	regulatory	JJ
cord-006229-7yoilsho	5871	9	science	science	NN
cord-006229-7yoilsho	5871	10	regarding	regard	VBG
cord-006229-7yoilsho	5871	11	the	the	DT
cord-006229-7yoilsho	5871	12	registration	registration	NN
cord-006229-7yoilsho	5871	13	of	of	IN
cord-006229-7yoilsho	5871	14	chemicals	chemical	NNS
cord-006229-7yoilsho	5871	15	,	,	,
cord-006229-7yoilsho	5871	16	agrochemicals	agrochemical	NNS
cord-006229-7yoilsho	5871	17	and	and	CC
cord-006229-7yoilsho	5871	18	cosmetics	cosmetic	NNS
cord-006229-7yoilsho	5871	19	.	.	.
cord-006229-7yoilsho	5872	1	The	the	DT
cord-006229-7yoilsho	5872	2	issue	issue	NN
cord-006229-7yoilsho	5872	3	has	have	VBZ
cord-006229-7yoilsho	5872	4	gained	gain	VBN
cord-006229-7yoilsho	5872	5	importance	importance	NN
cord-006229-7yoilsho	5872	6	since	since	IN
cord-006229-7yoilsho	5872	7	it	-PRON-	PRP
cord-006229-7yoilsho	5872	8	has	have	VBZ
cord-006229-7yoilsho	5872	9	been	be	VBN
cord-006229-7yoilsho	5872	10	realized	realize	VBN
cord-006229-7yoilsho	5872	11	that	that	IN
cord-006229-7yoilsho	5872	12	the	the	DT
cord-006229-7yoilsho	5872	13	skin	skin	NN
cord-006229-7yoilsho	5872	14	is	be	VBZ
cord-006229-7yoilsho	5872	15	not	not	RB
cord-006229-7yoilsho	5872	16	completely	completely	RB
cord-006229-7yoilsho	5872	17	impenetrable	impenetrable	JJ
cord-006229-7yoilsho	5872	18	for	for	IN
cord-006229-7yoilsho	5872	19	chemical	chemical	JJ
cord-006229-7yoilsho	5872	20	substances	substance	NNS
cord-006229-7yoilsho	5872	21	.	.	.
cord-006229-7yoilsho	5873	1	[	[	-LRB-
cord-006229-7yoilsho	5873	2	1	1	CD
cord-006229-7yoilsho	5873	3	]	]	-RRB-
cord-006229-7yoilsho	5874	1	The	the	DT
cord-006229-7yoilsho	5874	2	different	different	JJ
cord-006229-7yoilsho	5874	3	ways	way	NNS
cord-006229-7yoilsho	5874	4	to	to	TO
cord-006229-7yoilsho	5874	5	assess	assess	VB
cord-006229-7yoilsho	5874	6	dermal	dermal	JJ
cord-006229-7yoilsho	5874	7	absorption	absorption	NN
cord-006229-7yoilsho	5874	8	range	range	NN
cord-006229-7yoilsho	5874	9	from	from	IN
cord-006229-7yoilsho	5874	10	QSAR	QSAR	NNP
cord-006229-7yoilsho	5874	11	models	model	NNS
cord-006229-7yoilsho	5874	12	to	to	TO
cord-006229-7yoilsho	5874	13	complex	complex	VB
cord-006229-7yoilsho	5874	14	in	in	IN
cord-006229-7yoilsho	5874	15	vivo	vivo	NN
cord-006229-7yoilsho	5874	16	studies	study	NNS
cord-006229-7yoilsho	5874	17	including	include	VBG
cord-006229-7yoilsho	5874	18	a	a	DT
cord-006229-7yoilsho	5874	19	complete	complete	JJ
cord-006229-7yoilsho	5874	20	toxicokinetic	toxicokinetic	JJ
cord-006229-7yoilsho	5874	21	examination	examination	NN
cord-006229-7yoilsho	5874	22	.	.	.
cord-006229-7yoilsho	5875	1	The	the	DT
cord-006229-7yoilsho	5875	2	choice	choice	NN
cord-006229-7yoilsho	5875	3	of	of	IN
cord-006229-7yoilsho	5875	4	method	method	NN
cord-006229-7yoilsho	5875	5	depends	depend	VBZ
cord-006229-7yoilsho	5875	6	on	on	IN
cord-006229-7yoilsho	5875	7	the	the	DT
cord-006229-7yoilsho	5875	8	question	question	NN
cord-006229-7yoilsho	5875	9	that	that	WDT
cord-006229-7yoilsho	5875	10	has	have	VBZ
cord-006229-7yoilsho	5875	11	to	to	TO
cord-006229-7yoilsho	5875	12	be	be	VB
cord-006229-7yoilsho	5875	13	answered	answer	VBN
cord-006229-7yoilsho	5875	14	as	as	IN
cord-006229-7yoilsho	5875	15	different	different	JJ
cord-006229-7yoilsho	5875	16	systems	system	NNS
cord-006229-7yoilsho	5875	17	give	give	VBP
cord-006229-7yoilsho	5875	18	different	different	JJ
cord-006229-7yoilsho	5875	19	results	result	NNS
cord-006229-7yoilsho	5875	20	:	:	:
cord-006229-7yoilsho	5875	21	absorption	absorption	NN
cord-006229-7yoilsho	5875	22	as	as	IN
cord-006229-7yoilsho	5875	23	%	%	NN
cord-006229-7yoilsho	5875	24	of	of	IN
cord-006229-7yoilsho	5875	25	applied	applied	JJ
cord-006229-7yoilsho	5875	26	dose	dose	NN
cord-006229-7yoilsho	5875	27	in	in	RB
cord-006229-7yoilsho	5875	28	in	in	IN
cord-006229-7yoilsho	5875	29	vivo	vivo	NN
cord-006229-7yoilsho	5875	30	studies	study	NNS
cord-006229-7yoilsho	5875	31	or	or	CC
cord-006229-7yoilsho	5875	32	permeability	permeability	NN
cord-006229-7yoilsho	5875	33	coefficient	coefficient	NN
cord-006229-7yoilsho	5875	34	and	and	CC
cord-006229-7yoilsho	5875	35	lag	lag	VB
cord-006229-7yoilsho	5875	36	time	time	NN
cord-006229-7yoilsho	5875	37	in	in	IN
cord-006229-7yoilsho	5875	38	infinite	infinite	JJ
cord-006229-7yoilsho	5875	39	dose	dose	NN
cord-006229-7yoilsho	5875	40	in	in	IN
cord-006229-7yoilsho	5875	41	vitro	vitro	FW
cord-006229-7yoilsho	5875	42	studies	study	NNS
cord-006229-7yoilsho	5875	43	[	[	-LRB-
cord-006229-7yoilsho	5875	44	1	1	CD
cord-006229-7yoilsho	5875	45	]	]	-RRB-
cord-006229-7yoilsho	5875	46	.	.	.
cord-006229-7yoilsho	5876	1	Ideally	ideally	RB
cord-006229-7yoilsho	5876	2	both	both	DT
cord-006229-7yoilsho	5876	3	data	datum	NNS
cord-006229-7yoilsho	5876	4	would	would	MD
cord-006229-7yoilsho	5876	5	be	be	VB
cord-006229-7yoilsho	5876	6	available	available	JJ
cord-006229-7yoilsho	5876	7	.	.	.
cord-006229-7yoilsho	5877	1	Since	since	IN
cord-006229-7yoilsho	5877	2	the	the	DT
cord-006229-7yoilsho	5877	3	OECD	OECD	NNP
cord-006229-7yoilsho	5877	4	has	have	VBZ
cord-006229-7yoilsho	5877	5	adopted	adopt	VBN
cord-006229-7yoilsho	5877	6	a	a	DT
cord-006229-7yoilsho	5877	7	guideline	guideline	NN
cord-006229-7yoilsho	5877	8	for	for	IN
cord-006229-7yoilsho	5877	9	assessing	assess	VBG
cord-006229-7yoilsho	5877	10	dermal	dermal	JJ
cord-006229-7yoilsho	5877	11	penetration	penetration	NN
cord-006229-7yoilsho	5877	12	in	in	IN
cord-006229-7yoilsho	5877	13	vitro	vitro	FW
cord-006229-7yoilsho	5877	14	in	in	IN
cord-006229-7yoilsho	5877	15	2004	2004	CD
cord-006229-7yoilsho	5877	16	the	the	DT
cord-006229-7yoilsho	5877	17	number	number	NN
cord-006229-7yoilsho	5877	18	of	of	IN
cord-006229-7yoilsho	5877	19	in	in	FW
cord-006229-7yoilsho	5877	20	vitro	vitro	FW
cord-006229-7yoilsho	5877	21	studies	study	NNS
cord-006229-7yoilsho	5877	22	is	be	VBZ
cord-006229-7yoilsho	5877	23	rising	rise	VBG
cord-006229-7yoilsho	5877	24	continuously	continuously	RB
cord-006229-7yoilsho	5877	25	.	.	.
cord-006229-7yoilsho	5878	1	Depending	depend	VBG
cord-006229-7yoilsho	5878	2	on	on	IN
cord-006229-7yoilsho	5878	3	the	the	DT
cord-006229-7yoilsho	5878	4	chosen	choose	VBN
cord-006229-7yoilsho	5878	5	method	method	NN
cord-006229-7yoilsho	5878	6	results	result	NNS
cord-006229-7yoilsho	5878	7	may	may	MD
cord-006229-7yoilsho	5878	8	vary	vary	VB
cord-006229-7yoilsho	5878	9	in	in	IN
cord-006229-7yoilsho	5878	10	reliability	reliability	NN
cord-006229-7yoilsho	5878	11	and	and	CC
cord-006229-7yoilsho	5878	12	in	in	IN
cord-006229-7yoilsho	5878	13	acceptance	acceptance	NN
cord-006229-7yoilsho	5878	14	by	by	IN
cord-006229-7yoilsho	5878	15	regulatory	regulatory	JJ
cord-006229-7yoilsho	5878	16	authorities	authority	NNS
cord-006229-7yoilsho	5878	17	.	.	.
cord-006229-7yoilsho	5879	1	The	the	DT
cord-006229-7yoilsho	5879	2	SkinAB	SkinAB	NNP
cord-006229-7yoilsho	5879	3	database	database	NN
cord-006229-7yoilsho	5879	4	[	[	-LRB-
cord-006229-7yoilsho	5879	5	BA1	BA1	NNP
cord-006229-7yoilsho	5879	6	]	]	-RRB-
cord-006229-7yoilsho	5879	7	contains	contain	VBZ
cord-006229-7yoilsho	5879	8	data	datum	NNS
cord-006229-7yoilsho	5879	9	for	for	IN
cord-006229-7yoilsho	5879	10	about	about	RB
cord-006229-7yoilsho	5879	11	600	600	CD
cord-006229-7yoilsho	5879	12	substances	substance	NNS
cord-006229-7yoilsho	5879	13	on	on	IN
cord-006229-7yoilsho	5879	14	dermal	dermal	JJ
cord-006229-7yoilsho	5879	15	absorption	absorption	NN
cord-006229-7yoilsho	5879	16	which	which	WDT
cord-006229-7yoilsho	5879	17	has	have	VBZ
cord-006229-7yoilsho	5879	18	been	be	VBN
cord-006229-7yoilsho	5879	19	found	find	VBN
cord-006229-7yoilsho	5879	20	through	through	IN
cord-006229-7yoilsho	5879	21	the	the	DT
cord-006229-7yoilsho	5879	22	eChemPortal	echemportal	JJ
cord-006229-7yoilsho	5879	23	[	[	-LRB-
cord-006229-7yoilsho	5879	24	3	3	CD
cord-006229-7yoilsho	5879	25	]	]	-RRB-
cord-006229-7yoilsho	5879	26	and	and	CC
cord-006229-7yoilsho	5879	27	extended	extend	VBN
cord-006229-7yoilsho	5879	28	with	with	IN
cord-006229-7yoilsho	5879	29	data	datum	NNS
cord-006229-7yoilsho	5879	30	from	from	IN
cord-006229-7yoilsho	5879	31	the	the	DT
cord-006229-7yoilsho	5879	32	EDETOX	EDETOX	NNP
cord-006229-7yoilsho	5879	33	database	database	NN
cord-006229-7yoilsho	5879	34	.	.	.
cord-006229-7yoilsho	5880	1	For	for	IN
cord-006229-7yoilsho	5880	2	selected	select	VBN
cord-006229-7yoilsho	5880	3	substances	substance	NNS
cord-006229-7yoilsho	5880	4	with	with	IN
cord-006229-7yoilsho	5880	5	a	a	DT
cord-006229-7yoilsho	5880	6	broad	broad	JJ
cord-006229-7yoilsho	5880	7	spectrum	spectrum	NN
cord-006229-7yoilsho	5880	8	of	of	IN
cord-006229-7yoilsho	5880	9	data	datum	NNS
cord-006229-7yoilsho	5880	10	available	available	JJ
cord-006229-7yoilsho	5880	11	further	further	JJ
cord-006229-7yoilsho	5880	12	analysis	analysis	NN
cord-006229-7yoilsho	5880	13	has	have	VBZ
cord-006229-7yoilsho	5880	14	now	now	RB
cord-006229-7yoilsho	5880	15	been	be	VBN
cord-006229-7yoilsho	5880	16	started	start	VBN
cord-006229-7yoilsho	5880	17	.	.	.
cord-006229-7yoilsho	5881	1	165	165	CD
cord-006229-7yoilsho	5881	2	chemicals	chemical	NNS
cord-006229-7yoilsho	5881	3	have	have	VBP
cord-006229-7yoilsho	5881	4	been	be	VBN
cord-006229-7yoilsho	5881	5	investigated	investigate	VBN
cord-006229-7yoilsho	5881	6	in	in	IN
cord-006229-7yoilsho	5881	7	a	a	DT
cord-006229-7yoilsho	5881	8	comparable	comparable	JJ
cord-006229-7yoilsho	5881	9	test	test	NN
cord-006229-7yoilsho	5881	10	system	system	NN
cord-006229-7yoilsho	5881	11	;	;	:
cord-006229-7yoilsho	5881	12	from	from	IN
cord-006229-7yoilsho	5881	13	these	these	DT
cord-006229-7yoilsho	5881	14	79	79	CD
cord-006229-7yoilsho	5881	15	were	be	VBD
cord-006229-7yoilsho	5881	16	shown	show	VBN
cord-006229-7yoilsho	5881	17	to	to	TO
cord-006229-7yoilsho	5881	18	have	have	VB
cord-006229-7yoilsho	5881	19	a	a	DT
cord-006229-7yoilsho	5881	20	low	low	JJ
cord-006229-7yoilsho	5881	21	dermal	dermal	JJ
cord-006229-7yoilsho	5881	22	absorption	absorption	NN
cord-006229-7yoilsho	5881	23	of	of	IN
cord-006229-7yoilsho	5881	24	less	less	JJR
cord-006229-7yoilsho	5881	25	than	than	IN
cord-006229-7yoilsho	5881	26	1	1	CD
cord-006229-7yoilsho	5881	27	%	%	NN
cord-006229-7yoilsho	5881	28	and	and	CC
cord-006229-7yoilsho	5881	29	51	51	CD
cord-006229-7yoilsho	5881	30	compounds	compound	NNS
cord-006229-7yoilsho	5881	31	showed	show	VBD
cord-006229-7yoilsho	5881	32	a	a	DT
cord-006229-7yoilsho	5881	33	high	high	JJ
cord-006229-7yoilsho	5881	34	absorption	absorption	NN
cord-006229-7yoilsho	5881	35	rate	rate	NN
cord-006229-7yoilsho	5881	36	of	of	IN
cord-006229-7yoilsho	5881	37	more	more	JJR
cord-006229-7yoilsho	5881	38	than	than	IN
cord-006229-7yoilsho	5881	39	50	50	CD
cord-006229-7yoilsho	5881	40	%	%	NN
cord-006229-7yoilsho	5881	41	.	.	.
cord-006229-7yoilsho	5882	1	For	for	IN
cord-006229-7yoilsho	5882	2	the	the	DT
cord-006229-7yoilsho	5882	3	assessment	assessment	NN
cord-006229-7yoilsho	5882	4	of	of	IN
cord-006229-7yoilsho	5882	5	dermal	dermal	JJ
cord-006229-7yoilsho	5882	6	exposure	exposure	NN
cord-006229-7yoilsho	5882	7	either	either	CC
cord-006229-7yoilsho	5882	8	the	the	DT
cord-006229-7yoilsho	5882	9	absorbed	absorbed	JJ
cord-006229-7yoilsho	5882	10	dose	dose	NN
cord-006229-7yoilsho	5882	11	in	in	IN
cord-006229-7yoilsho	5882	12	percent	percent	NN
cord-006229-7yoilsho	5882	13	or	or	CC
cord-006229-7yoilsho	5882	14	the	the	DT
cord-006229-7yoilsho	5882	15	flux	flux	NN
cord-006229-7yoilsho	5882	16	can	can	MD
cord-006229-7yoilsho	5882	17	be	be	VB
cord-006229-7yoilsho	5882	18	measured	measure	VBN
cord-006229-7yoilsho	5882	19	.	.	.
cord-006229-7yoilsho	5883	1	Data	data	NN
cord-006229-7yoilsho	5883	2	analysis	analysis	NN
cord-006229-7yoilsho	5883	3	showed	show	VBD
cord-006229-7yoilsho	5883	4	that	that	IN
cord-006229-7yoilsho	5883	5	only	only	RB
cord-006229-7yoilsho	5883	6	for	for	IN
cord-006229-7yoilsho	5883	7	15	15	CD
cord-006229-7yoilsho	5883	8	substances	substance	NNS
cord-006229-7yoilsho	5883	9	both	both	DT
cord-006229-7yoilsho	5883	10	is	be	VBZ
cord-006229-7yoilsho	5883	11	available	available	JJ
cord-006229-7yoilsho	5883	12	:	:	:
cord-006229-7yoilsho	5883	13	flux	flux	NN
cord-006229-7yoilsho	5883	14	data	datum	NNS
cord-006229-7yoilsho	5883	15	from	from	IN
cord-006229-7yoilsho	5883	16	in	in	IN
cord-006229-7yoilsho	5883	17	vitro	vitro	FW
cord-006229-7yoilsho	5883	18	studies	study	NNS
cord-006229-7yoilsho	5883	19	and	and	CC
cord-006229-7yoilsho	5883	20	absorption	absorption	NN
cord-006229-7yoilsho	5883	21	data	datum	NNS
cord-006229-7yoilsho	5883	22	from	from	IN
cord-006229-7yoilsho	5883	23	in	in	IN
cord-006229-7yoilsho	5883	24	vivo	vivo	NNP
cord-006229-7yoilsho	5883	25	studies	study	NNS
cord-006229-7yoilsho	5883	26	.	.	.
cord-006229-7yoilsho	5884	1	This	this	DT
cord-006229-7yoilsho	5884	2	data	data	NN
cord-006229-7yoilsho	5884	3	could	could	MD
cord-006229-7yoilsho	5884	4	be	be	VB
cord-006229-7yoilsho	5884	5	used	use	VBN
cord-006229-7yoilsho	5884	6	to	to	TO
cord-006229-7yoilsho	5884	7	clarify	clarify	VB
cord-006229-7yoilsho	5884	8	which	which	WDT
cord-006229-7yoilsho	5884	9	parameter	parameter	NN
cord-006229-7yoilsho	5884	10	would	would	MD
cord-006229-7yoilsho	5884	11	be	be	VB
cord-006229-7yoilsho	5884	12	most	most	RBS
cord-006229-7yoilsho	5884	13	useful	useful	JJ
cord-006229-7yoilsho	5884	14	for	for	IN
cord-006229-7yoilsho	5884	15	exposure	exposure	NN
cord-006229-7yoilsho	5884	16	assessment	assessment	NN
cord-006229-7yoilsho	5884	17	regarding	regard	VBG
cord-006229-7yoilsho	5884	18	dermal	dermal	JJ
cord-006229-7yoilsho	5884	19	exposure	exposure	NN
cord-006229-7yoilsho	5884	20	.	.	.
cord-006229-7yoilsho	5885	1	Seven	seven	CD
cord-006229-7yoilsho	5885	2	substances	substance	NNS
cord-006229-7yoilsho	5885	3	in	in	IN
cord-006229-7yoilsho	5885	4	the	the	DT
cord-006229-7yoilsho	5885	5	dataset	dataset	NN
cord-006229-7yoilsho	5885	6	were	be	VBD
cord-006229-7yoilsho	5885	7	conspicuous	conspicuous	JJ
cord-006229-7yoilsho	5885	8	for	for	IN
cord-006229-7yoilsho	5885	9	their	-PRON-	PRP$
cord-006229-7yoilsho	5885	10	range	range	NN
cord-006229-7yoilsho	5885	11	of	of	IN
cord-006229-7yoilsho	5885	12	absorption	absorption	NN
cord-006229-7yoilsho	5885	13	rates	rate	NNS
cord-006229-7yoilsho	5885	14	in	in	IN
cord-006229-7yoilsho	5885	15	different	different	JJ
cord-006229-7yoilsho	5885	16	studies	study	NNS
cord-006229-7yoilsho	5885	17	:	:	:
cord-006229-7yoilsho	5885	18	less	less	JJR
cord-006229-7yoilsho	5885	19	than	than	IN
cord-006229-7yoilsho	5885	20	1	1	CD
cord-006229-7yoilsho	5885	21	%	%	NN
cord-006229-7yoilsho	5885	22	to	to	IN
cord-006229-7yoilsho	5885	23	more	more	JJR
cord-006229-7yoilsho	5885	24	than	than	IN
cord-006229-7yoilsho	5885	25	50	50	CD
cord-006229-7yoilsho	5885	26	%	%	NN
cord-006229-7yoilsho	5885	27	.	.	.
cord-006229-7yoilsho	5886	1	An	an	DT
cord-006229-7yoilsho	5886	2	in	in	IN
cord-006229-7yoilsho	5886	3	depth	depth	NN
cord-006229-7yoilsho	5886	4	analysis	analysis	NN
cord-006229-7yoilsho	5886	5	revealed	reveal	VBD
cord-006229-7yoilsho	5886	6	the	the	DT
cord-006229-7yoilsho	5886	7	complex	complex	JJ
cord-006229-7yoilsho	5886	8	influence	influence	NN
cord-006229-7yoilsho	5886	9	that	that	WDT
cord-006229-7yoilsho	5886	10	different	different	JJ
cord-006229-7yoilsho	5886	11	exposure	exposure	NN
cord-006229-7yoilsho	5886	12	parameters	parameter	NNS
cord-006229-7yoilsho	5886	13	have	have	VBP
cord-006229-7yoilsho	5886	14	on	on	IN
cord-006229-7yoilsho	5886	15	the	the	DT
cord-006229-7yoilsho	5886	16	results	result	NNS
cord-006229-7yoilsho	5886	17	of	of	IN
cord-006229-7yoilsho	5886	18	dermal	dermal	JJ
cord-006229-7yoilsho	5886	19	absorption	absorption	NN
cord-006229-7yoilsho	5886	20	studies	study	NNS
cord-006229-7yoilsho	5886	21	.	.	.
cord-006229-7yoilsho	5887	1	For	for	IN
cord-006229-7yoilsho	5887	2	some	some	DT
cord-006229-7yoilsho	5887	3	chemicals	chemical	NNS
cord-006229-7yoilsho	5887	4	the	the	DT
cord-006229-7yoilsho	5887	5	influence	influence	NN
cord-006229-7yoilsho	5887	6	of	of	IN
cord-006229-7yoilsho	5887	7	exposure	exposure	NN
cord-006229-7yoilsho	5887	8	time	time	NN
cord-006229-7yoilsho	5887	9	on	on	IN
cord-006229-7yoilsho	5887	10	increasing	increase	VBG
cord-006229-7yoilsho	5887	11	absorption	absorption	NN
cord-006229-7yoilsho	5887	12	values	value	NNS
cord-006229-7yoilsho	5887	13	could	could	MD
cord-006229-7yoilsho	5887	14	be	be	VB
cord-006229-7yoilsho	5887	15	clearly	clearly	RB
cord-006229-7yoilsho	5887	16	demonstrated	demonstrate	VBN
cord-006229-7yoilsho	5887	17	.	.	.
cord-006229-7yoilsho	5888	1	Beside	beside	IN
cord-006229-7yoilsho	5888	2	other	other	JJ
cord-006229-7yoilsho	5888	3	factors	factor	NNS
cord-006229-7yoilsho	5888	4	such	such	JJ
cord-006229-7yoilsho	5888	5	as	as	IN
cord-006229-7yoilsho	5888	6	the	the	DT
cord-006229-7yoilsho	5888	7	chosen	choose	VBN
cord-006229-7yoilsho	5888	8	vehicle	vehicle	NN
cord-006229-7yoilsho	5888	9	,	,	,
cord-006229-7yoilsho	5888	10	and	and	CC
cord-006229-7yoilsho	5888	11	the	the	DT
cord-006229-7yoilsho	5888	12	(	(	-LRB-
cord-006229-7yoilsho	5888	13	non-)occlusion	non-)occlusion	NN
cord-006229-7yoilsho	5888	14	of	of	IN
cord-006229-7yoilsho	5888	15	the	the	DT
cord-006229-7yoilsho	5888	16	site	site	NN
cord-006229-7yoilsho	5888	17	of	of	IN
cord-006229-7yoilsho	5888	18	exposure	exposure	NN
cord-006229-7yoilsho	5888	19	especially	especially	RB
cord-006229-7yoilsho	5888	20	the	the	DT
cord-006229-7yoilsho	5888	21	choice	choice	NN
cord-006229-7yoilsho	5888	22	species	specie	NNS
cord-006229-7yoilsho	5888	23	introduced	introduce	VBD
cord-006229-7yoilsho	5888	24	a	a	DT
cord-006229-7yoilsho	5888	25	high	high	JJ
cord-006229-7yoilsho	5888	26	variability	variability	NN
cord-006229-7yoilsho	5888	27	;	;	:
cord-006229-7yoilsho	5888	28	this	this	DT
cord-006229-7yoilsho	5888	29	holds	hold	VBZ
cord-006229-7yoilsho	5888	30	even	even	RB
cord-006229-7yoilsho	5888	31	for	for	IN
cord-006229-7yoilsho	5888	32	the	the	DT
cord-006229-7yoilsho	5888	33	most	most	RBS
cord-006229-7yoilsho	5888	34	common	common	JJ
cord-006229-7yoilsho	5888	35	laboratory	laboratory	NN
cord-006229-7yoilsho	5888	36	animals	animal	NNS
cord-006229-7yoilsho	5888	37	t.	t.	NNP
cord-006229-7yoilsho	5889	1	A	a	DT
cord-006229-7yoilsho	5889	2	review	review	NN
cord-006229-7yoilsho	5889	3	published	publish	VBN
cord-006229-7yoilsho	5889	4	by	by	IN
cord-006229-7yoilsho	5889	5	Jung	Jung	NNP
cord-006229-7yoilsho	5889	6	in	in	IN
cord-006229-7yoilsho	5889	7	2015	2015	CD
cord-006229-7yoilsho	5889	8	[	[	-LRB-
cord-006229-7yoilsho	5889	9	5	5	CD
cord-006229-7yoilsho	5889	10	]	]	-RRB-
cord-006229-7yoilsho	5889	11	which	which	WDT
cord-006229-7yoilsho	5889	12	comes	come	VBZ
cord-006229-7yoilsho	5889	13	to	to	IN
cord-006229-7yoilsho	5889	14	the	the	DT
cord-006229-7yoilsho	5889	15	conclusion	conclusion	NN
cord-006229-7yoilsho	5889	16	that	that	IN
cord-006229-7yoilsho	5889	17	i.e.	i.e.	FW
cord-006229-7yoilsho	5889	18	hairless	hairless	JJ
cord-006229-7yoilsho	5889	19	species	specie	NNS
cord-006229-7yoilsho	5889	20	are	be	VBP
cord-006229-7yoilsho	5889	21	usually	usually	RB
cord-006229-7yoilsho	5889	22	not	not	RB
cord-006229-7yoilsho	5889	23	a	a	DT
cord-006229-7yoilsho	5889	24	good	good	JJ
cord-006229-7yoilsho	5889	25	model	model	NN
cord-006229-7yoilsho	5889	26	to	to	TO
cord-006229-7yoilsho	5889	27	predict	predict	VB
cord-006229-7yoilsho	5889	28	dermal	dermal	JJ
cord-006229-7yoilsho	5889	29	absorption	absorption	NN
cord-006229-7yoilsho	5889	30	in	in	IN
cord-006229-7yoilsho	5889	31	humans	human	NNS
cord-006229-7yoilsho	5889	32	.	.	.
cord-006229-7yoilsho	5890	1	[	[	-LRB-
cord-006229-7yoilsho	5890	2	1]WHO	1]who	CD
cord-006229-7yoilsho	5890	3	(	(	-LRB-
cord-006229-7yoilsho	5890	4	2006	2006	CD
cord-006229-7yoilsho	5890	5	)	)	-RRB-
cord-006229-7yoilsho	5891	1	EHC	EHC	NNP
cord-006229-7yoilsho	5891	2	235	235	CD
cord-006229-7yoilsho	5891	3	Dermal	dermal	JJ
cord-006229-7yoilsho	5891	4	absorption	absorption	NN
cord-006229-7yoilsho	5892	1	[	[	-LRB-
cord-006229-7yoilsho	5892	2	2	2	LS
cord-006229-7yoilsho	5892	3	]	]	-RRB-
cord-006229-7yoilsho	5892	4	Scholz	Scholz	NNP
cord-006229-7yoilsho	5892	5	et	et	FW
cord-006229-7yoilsho	5892	6	al	al	NNP
cord-006229-7yoilsho	5892	7	(	(	-LRB-
cord-006229-7yoilsho	5892	8	2014	2014	CD
cord-006229-7yoilsho	5892	9	)	)	-RRB-
cord-006229-7yoilsho	5893	1	Naunyn	Naunyn	NNP
cord-006229-7yoilsho	5893	2	-	-	HYPH
cord-006229-7yoilsho	5893	3	Schmiedeberg´s	Schmiedeberg´s	NNP
cord-006229-7yoilsho	5893	4	Arch	Arch	NNP
cord-006229-7yoilsho	5893	5	Pharmacol	Pharmacol	NNP
cord-006229-7yoilsho	5893	6	3	3	CD
cord-006229-7yoilsho	5894	1	(	(	-LRB-
cord-006229-7yoilsho	5894	2	Suppl	Suppl	NNP
cord-006229-7yoilsho	5894	3	1):S86	1):S86	NNP
cord-006229-7yoilsho	5894	4	[	[	-LRB-
cord-006229-7yoilsho	5894	5	3	3	CD
cord-006229-7yoilsho	5894	6	]	]	-RRB-
cord-006229-7yoilsho	5894	7	www.echemportal.org	www.echemportal.org	.
cord-006229-7yoilsho	5895	1	[	[	-LRB-
cord-006229-7yoilsho	5895	2	4	4	LS
cord-006229-7yoilsho	5895	3	]	]	-RRB-
cord-006229-7yoilsho	5895	4	http://edetox.ncl.ac.uk	http://edetox.ncl.ac.uk	NNP
cord-006229-7yoilsho	5895	5	[	[	-LRB-
cord-006229-7yoilsho	5895	6	5	5	CD
cord-006229-7yoilsho	5895	7	]	]	-RRB-
cord-006229-7yoilsho	5896	1	Jung	Jung	NNP
cord-006229-7yoilsho	5896	2	et	et	NNP
cord-006229-7yoilsho	5896	3	al	al	NNP
cord-006229-7yoilsho	5896	4	(	(	-LRB-
cord-006229-7yoilsho	5896	5	2015	2015	CD
cord-006229-7yoilsho	5896	6	)	)	-RRB-
cord-006229-7yoilsho	5897	1	In	in	IN
cord-006229-7yoilsho	5897	2	-	-	HYPH
cord-006229-7yoilsho	5897	3	silico	silico	NN
cord-006229-7yoilsho	5897	4	methods	method	NNS
cord-006229-7yoilsho	5897	5	have	have	VBP
cord-006229-7yoilsho	5897	6	evolved	evolve	VBN
cord-006229-7yoilsho	5897	7	to	to	IN
cord-006229-7yoilsho	5897	8	indispensable	indispensable	JJ
cord-006229-7yoilsho	5897	9	tools	tool	NNS
cord-006229-7yoilsho	5897	10	in	in	IN
cord-006229-7yoilsho	5897	11	various	various	JJ
cord-006229-7yoilsho	5897	12	areas	area	NNS
cord-006229-7yoilsho	5897	13	of	of	IN
cord-006229-7yoilsho	5897	14	life	life	NN
cord-006229-7yoilsho	5897	15	sciences	science	NNS
cord-006229-7yoilsho	5897	16	.	.	.
cord-006229-7yoilsho	5898	1	Several	several	JJ
cord-006229-7yoilsho	5898	2	stages	stage	NNS
cord-006229-7yoilsho	5898	3	in	in	IN
cord-006229-7yoilsho	5898	4	drug	drug	NN
cord-006229-7yoilsho	5898	5	development	development	NN
cord-006229-7yoilsho	5898	6	including	include	VBG
cord-006229-7yoilsho	5898	7	hit	hit	VBN
cord-006229-7yoilsho	5898	8	identification	identification	NN
cord-006229-7yoilsho	5898	9	and	and	CC
cord-006229-7yoilsho	5898	10	lead	lead	NN
cord-006229-7yoilsho	5898	11	optimization	optimization	NN
cord-006229-7yoilsho	5898	12	,	,	,
cord-006229-7yoilsho	5898	13	for	for	IN
cord-006229-7yoilsho	5898	14	instance	instance	NN
cord-006229-7yoilsho	5898	15	,	,	,
cord-006229-7yoilsho	5898	16	highly	highly	RB
cord-006229-7yoilsho	5898	17	benefit	benefit	VBP
cord-006229-7yoilsho	5898	18	from	from	IN
cord-006229-7yoilsho	5898	19	an	an	DT
cord-006229-7yoilsho	5898	20	accurate	accurate	JJ
cord-006229-7yoilsho	5898	21	estimation	estimation	NN
cord-006229-7yoilsho	5898	22	of	of	IN
cord-006229-7yoilsho	5898	23	binding	bind	VBG
cord-006229-7yoilsho	5898	24	free	free	JJ
cord-006229-7yoilsho	5898	25	energies	energy	NNS
cord-006229-7yoilsho	5898	26	associated	associate	VBN
cord-006229-7yoilsho	5898	27	with	with	IN
cord-006229-7yoilsho	5898	28	biological	biological	JJ
cord-006229-7yoilsho	5898	29	host	host	NN
cord-006229-7yoilsho	5898	30	-	-	HYPH
cord-006229-7yoilsho	5898	31	guest	guest	NN
cord-006229-7yoilsho	5898	32	systems	system	NNS
cord-006229-7yoilsho	5898	33	.	.	.
cord-006229-7yoilsho	5899	1	As	as	IN
cord-006229-7yoilsho	5899	2	a	a	DT
cord-006229-7yoilsho	5899	3	consequence	consequence	NN
cord-006229-7yoilsho	5899	4	,	,	,
cord-006229-7yoilsho	5899	5	the	the	DT
cord-006229-7yoilsho	5899	6	need	need	NN
cord-006229-7yoilsho	5899	7	for	for	IN
cord-006229-7yoilsho	5899	8	laboratory	laboratory	NN
cord-006229-7yoilsho	5899	9	experiments	experiment	NNS
cord-006229-7yoilsho	5899	10	including	include	VBG
cord-006229-7yoilsho	5899	11	in	in	IN
cord-006229-7yoilsho	5899	12	-	-	HYPH
cord-006229-7yoilsho	5899	13	vivo	vivo	NN
cord-006229-7yoilsho	5899	14	experiments	experiment	NNS
cord-006229-7yoilsho	5899	15	and	and	CC
cord-006229-7yoilsho	5899	16	animal	animal	NN
cord-006229-7yoilsho	5899	17	testing	testing	NN
cord-006229-7yoilsho	5899	18	is	be	VBZ
cord-006229-7yoilsho	5899	19	considerably	considerably	RB
cord-006229-7yoilsho	5899	20	reduced	reduce	VBN
cord-006229-7yoilsho	5899	21	.	.	.
cord-006229-7yoilsho	5900	1	Another	another	DT
cord-006229-7yoilsho	5900	2	field	field	NN
cord-006229-7yoilsho	5900	3	profiting	profit	VBG
cord-006229-7yoilsho	5900	4	from	from	IN
cord-006229-7yoilsho	5900	5	free	free	JJ
cord-006229-7yoilsho	5900	6	energy	energy	NN
cord-006229-7yoilsho	5900	7	calculations	calculation	NNS
cord-006229-7yoilsho	5900	8	is	be	VBZ
cord-006229-7yoilsho	5900	9	human	human	JJ
cord-006229-7yoilsho	5900	10	as	as	RB
cord-006229-7yoilsho	5900	11	well	well	RB
cord-006229-7yoilsho	5900	12	as	as	IN
cord-006229-7yoilsho	5900	13	ecotoxicology	ecotoxicology	NN
cord-006229-7yoilsho	5900	14	.	.	.
cord-006229-7yoilsho	5901	1	Upon	upon	IN
cord-006229-7yoilsho	5901	2	the	the	DT
cord-006229-7yoilsho	5901	3	development	development	NN
cord-006229-7yoilsho	5901	4	and	and	CC
cord-006229-7yoilsho	5901	5	risk	risk	NN
cord-006229-7yoilsho	5901	6	assessment	assessment	NN
cord-006229-7yoilsho	5901	7	of	of	IN
cord-006229-7yoilsho	5901	8	new	new	JJ
cord-006229-7yoilsho	5901	9	chemicals	chemical	NNS
cord-006229-7yoilsho	5901	10	,	,	,
cord-006229-7yoilsho	5901	11	transformation	transformation	NN
cord-006229-7yoilsho	5901	12	products	product	NNS
cord-006229-7yoilsho	5901	13	arising	arise	VBG
cord-006229-7yoilsho	5901	14	from	from	IN
cord-006229-7yoilsho	5901	15	biotic	biotic	JJ
cord-006229-7yoilsho	5901	16	or	or	CC
cord-006229-7yoilsho	5901	17	abiotic	abiotic	JJ
cord-006229-7yoilsho	5901	18	degradation	degradation	NN
cord-006229-7yoilsho	5901	19	of	of	IN
cord-006229-7yoilsho	5901	20	the	the	DT
cord-006229-7yoilsho	5901	21	parent	parent	NN
cord-006229-7yoilsho	5901	22	substance	substance	NN
cord-006229-7yoilsho	5901	23	have	have	VBP
cord-006229-7yoilsho	5901	24	usually	usually	RB
cord-006229-7yoilsho	5901	25	been	be	VBN
cord-006229-7yoilsho	5901	26	neglected	neglect	VBN
cord-006229-7yoilsho	5901	27	.	.	.
cord-006229-7yoilsho	5902	1	However	however	RB
cord-006229-7yoilsho	5902	2	,	,	,
cord-006229-7yoilsho	5902	3	since	since	IN
cord-006229-7yoilsho	5902	4	few	few	JJ
cord-006229-7yoilsho	5902	5	years	year	NNS
cord-006229-7yoilsho	5902	6	,	,	,
cord-006229-7yoilsho	5902	7	the	the	DT
cord-006229-7yoilsho	5902	8	risk	risk	NN
cord-006229-7yoilsho	5902	9	assessment	assessment	NN
cord-006229-7yoilsho	5902	10	of	of	IN
cord-006229-7yoilsho	5902	11	new	new	JJ
cord-006229-7yoilsho	5902	12	chemicals	chemical	NNS
cord-006229-7yoilsho	5902	13	often	often	RB
cord-006229-7yoilsho	5902	14	includes	include	VBZ
cord-006229-7yoilsho	5902	15	transformation	transformation	NN
cord-006229-7yoilsho	5902	16	products	product	NNS
cord-006229-7yoilsho	5902	17	probably	probably	RB
cord-006229-7yoilsho	5902	18	causing	cause	VBG
cord-006229-7yoilsho	5902	19	more	more	JJR
cord-006229-7yoilsho	5902	20	harm	harm	NN
cord-006229-7yoilsho	5902	21	than	than	IN
cord-006229-7yoilsho	5902	22	the	the	DT
cord-006229-7yoilsho	5902	23	parent	parent	NN
cord-006229-7yoilsho	5902	24	substance	substance	NN
cord-006229-7yoilsho	5902	25	itself	-PRON-	PRP
cord-006229-7yoilsho	5902	26	.	.	.
cord-006229-7yoilsho	5903	1	Such	such	JJ
cord-006229-7yoilsho	5903	2	studies	study	NNS
cord-006229-7yoilsho	5903	3	as	as	RB
cord-006229-7yoilsho	5903	4	well	well	RB
cord-006229-7yoilsho	5903	5	are	be	VBP
cord-006229-7yoilsho	5903	6	mostly	mostly	RB
cord-006229-7yoilsho	5903	7	carried	carry	VBN
cord-006229-7yoilsho	5903	8	out	out	RP
cord-006229-7yoilsho	5903	9	on	on	IN
cord-006229-7yoilsho	5903	10	the	the	DT
cord-006229-7yoilsho	5903	11	basis	basis	NN
cord-006229-7yoilsho	5903	12	of	of	IN
cord-006229-7yoilsho	5903	13	in	in	IN
cord-006229-7yoilsho	5903	14	-	-	HYPH
cord-006229-7yoilsho	5903	15	vitro	vitro	FW
cord-006229-7yoilsho	5903	16	and	and	CC
cord-006229-7yoilsho	5903	17	in	in	IN
cord-006229-7yoilsho	5903	18	-	-	HYPH
cord-006229-7yoilsho	5903	19	vivo	vivo	NN
cord-006229-7yoilsho	5903	20	tests	test	NNS
cord-006229-7yoilsho	5903	21	.	.	.
cord-006229-7yoilsho	5904	1	Moreover	moreover	RB
cord-006229-7yoilsho	5904	2	,	,	,
cord-006229-7yoilsho	5904	3	many	many	JJ
cord-006229-7yoilsho	5904	4	metabolites	metabolite	NNS
cord-006229-7yoilsho	5904	5	can	can	MD
cord-006229-7yoilsho	5904	6	be	be	VB
cord-006229-7yoilsho	5904	7	detected	detect	VBN
cord-006229-7yoilsho	5904	8	but	but	CC
cord-006229-7yoilsho	5904	9	neither	neither	CC
cord-006229-7yoilsho	5904	10	enriched	enrich	VBN
cord-006229-7yoilsho	5904	11	nor	nor	CC
cord-006229-7yoilsho	5904	12	synthesized	synthesize	VBN
cord-006229-7yoilsho	5904	13	in	in	IN
cord-006229-7yoilsho	5904	14	amount	amount	NN
cord-006229-7yoilsho	5904	15	sufficient	sufficient	JJ
cord-006229-7yoilsho	5904	16	for	for	IN
cord-006229-7yoilsho	5904	17	toxicological	toxicological	JJ
cord-006229-7yoilsho	5904	18	evaluations	evaluation	NNS
cord-006229-7yoilsho	5904	19	.	.	.
cord-006229-7yoilsho	5905	1	At	at	IN
cord-006229-7yoilsho	5905	2	this	this	DT
cord-006229-7yoilsho	5905	3	stage	stage	NN
cord-006229-7yoilsho	5905	4	,	,	,
cord-006229-7yoilsho	5905	5	computational	computational	JJ
cord-006229-7yoilsho	5905	6	methods	method	NNS
cord-006229-7yoilsho	5905	7	come	come	VBP
cord-006229-7yoilsho	5905	8	into	into	IN
cord-006229-7yoilsho	5905	9	play	play	NN
cord-006229-7yoilsho	5905	10	.	.	.
cord-006229-7yoilsho	5906	1	Using	use	VBG
cord-006229-7yoilsho	5906	2	classical	classical	JJ
cord-006229-7yoilsho	5906	3	molecular	molecular	JJ
cord-006229-7yoilsho	5906	4	dynamics	dynamic	NNS
cord-006229-7yoilsho	5906	5	simulations	simulation	NNS
cord-006229-7yoilsho	5906	6	in	in	IN
cord-006229-7yoilsho	5906	7	combination	combination	NN
cord-006229-7yoilsho	5906	8	with	with	IN
cord-006229-7yoilsho	5906	9	an	an	DT
cord-006229-7yoilsho	5906	10	empirical	empirical	JJ
cord-006229-7yoilsho	5906	11	linear	linear	JJ
cord-006229-7yoilsho	5906	12	prediction	prediction	NN
cord-006229-7yoilsho	5906	13	model	model	NN
cord-006229-7yoilsho	5906	14	,	,	,
cord-006229-7yoilsho	5906	15	we	-PRON-	PRP
cord-006229-7yoilsho	5906	16	have	have	VBP
cord-006229-7yoilsho	5906	17	investigated	investigate	VBN
cord-006229-7yoilsho	5906	18	several	several	JJ
cord-006229-7yoilsho	5906	19	metabolites	metabolite	NNS
cord-006229-7yoilsho	5906	20	of	of	IN
cord-006229-7yoilsho	5906	21	the	the	DT
cord-006229-7yoilsho	5906	22	drugs	drug	NNS
cord-006229-7yoilsho	5906	23	sulfamethoxazole	sulfamethoxazole	NNP
cord-006229-7yoilsho	5906	24	and	and	CC
cord-006229-7yoilsho	5906	25	carbamazepine	carbamazepine	NN
cord-006229-7yoilsho	5906	26	and	and	CC
cord-006229-7yoilsho	5906	27	prioritized	prioritize	VBD
cord-006229-7yoilsho	5906	28	them	-PRON-	PRP
cord-006229-7yoilsho	5906	29	according	accord	VBG
cord-006229-7yoilsho	5906	30	to	to	IN
cord-006229-7yoilsho	5906	31	their	-PRON-	PRP$
cord-006229-7yoilsho	5906	32	estimated	estimate	VBN
cord-006229-7yoilsho	5906	33	binding	bind	VBG
cord-006229-7yoilsho	5906	34	affinities	affinity	NNS
cord-006229-7yoilsho	5906	35	to	to	IN
cord-006229-7yoilsho	5906	36	potential	potential	JJ
cord-006229-7yoilsho	5906	37	biological	biological	JJ
cord-006229-7yoilsho	5906	38	target	target	NN
cord-006229-7yoilsho	5906	39	proteins	protein	NNS
cord-006229-7yoilsho	5906	40	.	.	.
cord-006229-7yoilsho	5907	1	Consequently	consequently	RB
cord-006229-7yoilsho	5907	2	,	,	,
cord-006229-7yoilsho	5907	3	a	a	DT
cord-006229-7yoilsho	5907	4	couple	couple	NN
cord-006229-7yoilsho	5907	5	of	of	IN
cord-006229-7yoilsho	5907	6	metabolites	metabolite	NNS
cord-006229-7yoilsho	5907	7	were	be	VBD
cord-006229-7yoilsho	5907	8	identified	identify	VBN
cord-006229-7yoilsho	5907	9	that	that	IN
cord-006229-7yoilsho	5907	10	bind	bind	VBP
cord-006229-7yoilsho	5907	11	to	to	IN
cord-006229-7yoilsho	5907	12	one	one	CD
cord-006229-7yoilsho	5907	13	or	or	CC
cord-006229-7yoilsho	5907	14	more	more	JJR
cord-006229-7yoilsho	5907	15	human	human	JJ
cord-006229-7yoilsho	5907	16	cytochrome	cytochrome	NN
cord-006229-7yoilsho	5907	17	P450	p450	JJ
cord-006229-7yoilsho	5907	18	variants	variant	NNS
cord-006229-7yoilsho	5907	19	and	and	CC
cord-006229-7yoilsho	5907	20	the	the	DT
cord-006229-7yoilsho	5907	21	bacterial	bacterial	JJ
cord-006229-7yoilsho	5907	22	enzyme	enzyme	NN
cord-006229-7yoilsho	5907	23	dihydropteroate	dihydropteroate	NN
cord-006229-7yoilsho	5907	24	synthase	synthase	NN
cord-006229-7yoilsho	5907	25	,	,	,
cord-006229-7yoilsho	5907	26	respectively	respectively	RB
cord-006229-7yoilsho	5907	27	,	,	,
cord-006229-7yoilsho	5907	28	which	which	WDT
cord-006229-7yoilsho	5907	29	are	be	VBP
cord-006229-7yoilsho	5907	30	known	know	VBN
cord-006229-7yoilsho	5907	31	to	to	TO
cord-006229-7yoilsho	5907	32	be	be	VB
cord-006229-7yoilsho	5907	33	sensitive	sensitive	JJ
cord-006229-7yoilsho	5907	34	to	to	IN
cord-006229-7yoilsho	5907	35	the	the	DT
cord-006229-7yoilsho	5907	36	two	two	CD
cord-006229-7yoilsho	5907	37	drugs	drug	NNS
cord-006229-7yoilsho	5907	38	.	.	.
cord-006229-7yoilsho	5908	1	The	the	DT
cord-006229-7yoilsho	5908	2	investigations	investigation	NNS
cord-006229-7yoilsho	5908	3	were	be	VBD
cord-006229-7yoilsho	5908	4	carried	carry	VBN
cord-006229-7yoilsho	5908	5	out	out	RP
cord-006229-7yoilsho	5908	6	in	in	IN
cord-006229-7yoilsho	5908	7	the	the	DT
cord-006229-7yoilsho	5908	8	framework	framework	NN
cord-006229-7yoilsho	5908	9	of	of	IN
cord-006229-7yoilsho	5908	10	the	the	DT
cord-006229-7yoilsho	5908	11	BB3R	BB3R	NNS
cord-006229-7yoilsho	5908	12	poject	poject	VB
cord-006229-7yoilsho	5908	13	funded	fund	VBN
cord-006229-7yoilsho	5908	14	by	by	IN
cord-006229-7yoilsho	5908	15	the	the	DT
cord-006229-7yoilsho	5908	16	German	german	JJ
cord-006229-7yoilsho	5908	17	government	government	NN
cord-006229-7yoilsho	5908	18	through	through	IN
cord-006229-7yoilsho	5908	19	BMBF	BMBF	NNP
cord-006229-7yoilsho	5908	20	.	.	.
cord-006229-7yoilsho	5909	1	Instituto	Instituto	NNP
cord-006229-7yoilsho	5909	2	Superiore	Superiore	NNP
cord-006229-7yoilsho	5910	1	di	di	NNP
cord-006229-7yoilsho	5910	2	Sanità	Sanità	NNP
cord-006229-7yoilsho	5910	3	,	,	,
cord-006229-7yoilsho	5910	4	Environment	Environment	NNP
cord-006229-7yoilsho	5910	5	and	and	CC
cord-006229-7yoilsho	5910	6	Primary	Primary	NNP
cord-006229-7yoilsho	5910	7	Prevention	Prevention	NNP
cord-006229-7yoilsho	5910	8	Dept	Dept	NNP
cord-006229-7yoilsho	5910	9	.	.	NNP
cord-006229-7yoilsho	5910	10	,	,	,
cord-006229-7yoilsho	5910	11	Rome	Rome	NNP
cord-006229-7yoilsho	5910	12	,	,	,
cord-006229-7yoilsho	5911	1	Italien	Italien	NNP
cord-006229-7yoilsho	5911	2	Introduction	introduction	NN
cord-006229-7yoilsho	5911	3	:	:	:
cord-006229-7yoilsho	5912	1	In	in	IN
cord-006229-7yoilsho	5912	2	vitro	vitro	FW
cord-006229-7yoilsho	5912	3	methods	method	NNS
cord-006229-7yoilsho	5912	4	have	have	VBP
cord-006229-7yoilsho	5912	5	been	be	VBN
cord-006229-7yoilsho	5912	6	increasingly	increasingly	RB
cord-006229-7yoilsho	5912	7	used	use	VBN
cord-006229-7yoilsho	5912	8	to	to	TO
cord-006229-7yoilsho	5912	9	characterize	characterize	VB
cord-006229-7yoilsho	5912	10	pharmacological	pharmacological	JJ
cord-006229-7yoilsho	5912	11	and	and	CC
cord-006229-7yoilsho	5912	12	toxicological	toxicological	JJ
cord-006229-7yoilsho	5912	13	properties	property	NNS
cord-006229-7yoilsho	5912	14	of	of	IN
cord-006229-7yoilsho	5912	15	substances	substance	NNS
cord-006229-7yoilsho	5912	16	.	.	.
cord-006229-7yoilsho	5913	1	To	to	TO
cord-006229-7yoilsho	5913	2	address	address	VB
cord-006229-7yoilsho	5913	3	the	the	DT
cord-006229-7yoilsho	5913	4	problem	problem	NN
cord-006229-7yoilsho	5913	5	of	of	IN
cord-006229-7yoilsho	5913	6	nominal	nominal	JJ
cord-006229-7yoilsho	5913	7	versus	versus	IN
cord-006229-7yoilsho	5913	8	actual	actual	JJ
cord-006229-7yoilsho	5913	9	concentrations	concentration	NNS
cord-006229-7yoilsho	5913	10	,	,	,
cord-006229-7yoilsho	5913	11	in	in	IN
cord-006229-7yoilsho	5913	12	vitro	vitro	FW
cord-006229-7yoilsho	5913	13	biokinetic	biokinetic	JJ
cord-006229-7yoilsho	5913	14	studies	study	NNS
cord-006229-7yoilsho	5913	15	were	be	VBD
cord-006229-7yoilsho	5913	16	recently	recently	RB
cord-006229-7yoilsho	5913	17	undertaken	undertake	VBN
cord-006229-7yoilsho	5914	1	(	(	-LRB-
cord-006229-7yoilsho	5914	2	Truisi	Truisi	NNP
cord-006229-7yoilsho	5914	3	et	et	NNP
cord-006229-7yoilsho	5914	4	al	al	NNP
cord-006229-7yoilsho	5914	5	.	.	.
cord-006229-7yoilsho	5915	1	,	,	,
cord-006229-7yoilsho	5915	2	Toxicol	Toxicol	NNP
cord-006229-7yoilsho	5915	3	Lett	Lett	NNP
cord-006229-7yoilsho	5915	4	233:172	233:172	CD
cord-006229-7yoilsho	5915	5	-	-	HYPH
cord-006229-7yoilsho	5915	6	86	86	CD
cord-006229-7yoilsho	5915	7	,	,	,
cord-006229-7yoilsho	5915	8	2015	2015	CD
cord-006229-7yoilsho	5915	9	)	)	-RRB-
cord-006229-7yoilsho	5915	10	.	.	.
cord-006229-7yoilsho	5916	1	We	-PRON-	PRP
cord-006229-7yoilsho	5916	2	use	use	VBP
cord-006229-7yoilsho	5916	3	those	those	DT
cord-006229-7yoilsho	5916	4	data	datum	NNS
cord-006229-7yoilsho	5916	5	as	as	IN
cord-006229-7yoilsho	5916	6	input	input	NN
cord-006229-7yoilsho	5916	7	into	into	IN
cord-006229-7yoilsho	5916	8	a	a	DT
cord-006229-7yoilsho	5916	9	physiologically	physiologically	RB
cord-006229-7yoilsho	5916	10	based	base	VBN
cord-006229-7yoilsho	5916	11	human	human	JJ
cord-006229-7yoilsho	5916	12	kinetic	kinetic	JJ
cord-006229-7yoilsho	5916	13	model	model	NN
cord-006229-7yoilsho	5916	14	(	(	-LRB-
cord-006229-7yoilsho	5916	15	PBHKM	PBHKM	NNP
cord-006229-7yoilsho	5916	16	)	)	-RRB-
cord-006229-7yoilsho	5916	17	to	to	TO
cord-006229-7yoilsho	5916	18	model	model	VB
cord-006229-7yoilsho	5916	19	the	the	DT
cord-006229-7yoilsho	5916	20	in	in	IN
cord-006229-7yoilsho	5916	21	vivo	vivo	NNP
cord-006229-7yoilsho	5916	22	doses	dose	NNS
cord-006229-7yoilsho	5916	23	leading	lead	VBG
cord-006229-7yoilsho	5916	24	to	to	IN
cord-006229-7yoilsho	5916	25	the	the	DT
cord-006229-7yoilsho	5916	26	in	in	FW
cord-006229-7yoilsho	5916	27	vitro	vitro	FW
cord-006229-7yoilsho	5916	28	measured	measure	VBN
cord-006229-7yoilsho	5916	29	concentrations	concentration	NNS
cord-006229-7yoilsho	5916	30	.	.	.
cord-006229-7yoilsho	5917	1	Methods	method	NNS
cord-006229-7yoilsho	5917	2	:	:	:
cord-006229-7yoilsho	5917	3	A	a	DT
cord-006229-7yoilsho	5917	4	PBHKM	PBHKM	NNP
cord-006229-7yoilsho	5917	5	was	be	VBD
cord-006229-7yoilsho	5917	6	used	use	VBN
cord-006229-7yoilsho	5917	7	to	to	TO
cord-006229-7yoilsho	5917	8	simulate	simulate	VB
cord-006229-7yoilsho	5917	9	the	the	DT
cord-006229-7yoilsho	5917	10	concentration	concentration	NN
cord-006229-7yoilsho	5917	11	time	time	NN
cord-006229-7yoilsho	5917	12	profile	profile	NN
cord-006229-7yoilsho	5917	13	of	of	IN
cord-006229-7yoilsho	5917	14	ibuprofen	ibuprofen	NN
cord-006229-7yoilsho	5917	15	in	in	IN
cord-006229-7yoilsho	5917	16	the	the	DT
cord-006229-7yoilsho	5917	17	hepatic	hepatic	JJ
cord-006229-7yoilsho	5917	18	vein	vein	NN
cord-006229-7yoilsho	5917	19	after	after	IN
cord-006229-7yoilsho	5917	20	oral	oral	JJ
cord-006229-7yoilsho	5917	21	administration	administration	NN
cord-006229-7yoilsho	5917	22	.	.	.
cord-006229-7yoilsho	5918	1	The	the	DT
cord-006229-7yoilsho	5918	2	details	detail	NNS
cord-006229-7yoilsho	5918	3	of	of	IN
cord-006229-7yoilsho	5918	4	the	the	DT
cord-006229-7yoilsho	5918	5	model	model	NN
cord-006229-7yoilsho	5918	6	and	and	CC
cord-006229-7yoilsho	5918	7	the	the	DT
cord-006229-7yoilsho	5918	8	physiological	physiological	JJ
cord-006229-7yoilsho	5918	9	parameters	parameter	NNS
cord-006229-7yoilsho	5918	10	used	use	VBN
cord-006229-7yoilsho	5918	11	have	have	VBP
cord-006229-7yoilsho	5918	12	been	be	VBN
cord-006229-7yoilsho	5918	13	described	describe	VBN
cord-006229-7yoilsho	5918	14	elsewhere	elsewhere	RB
cord-006229-7yoilsho	5919	1	(	(	-LRB-
cord-006229-7yoilsho	5919	2	Abraham	Abraham	NNP
cord-006229-7yoilsho	5919	3	et	et	NNP
cord-006229-7yoilsho	5919	4	al	al	NNP
cord-006229-7yoilsho	5919	5	.	.	.
cord-006229-7yoilsho	5920	1	,	,	,
cord-006229-7yoilsho	5920	2	Arch	Arch	NNP
cord-006229-7yoilsho	5920	3	.	.	.
cord-006229-7yoilsho	5921	1	Toxicology	Toxicology	NNP
cord-006229-7yoilsho	5921	2	79	79	CD
cord-006229-7yoilsho	5921	3	:	:	SYM
cord-006229-7yoilsho	5921	4	63	63	CD
cord-006229-7yoilsho	5921	5	-	-	SYM
cord-006229-7yoilsho	5921	6	73	73	CD
cord-006229-7yoilsho	5921	7	,	,	,
cord-006229-7yoilsho	5921	8	2004	2004	CD
cord-006229-7yoilsho	5921	9	)	)	-RRB-
cord-006229-7yoilsho	5921	10	.	.	.
cord-006229-7yoilsho	5922	1	We	-PRON-	PRP
cord-006229-7yoilsho	5922	2	modelled	model	VBD
cord-006229-7yoilsho	5922	3	the	the	DT
cord-006229-7yoilsho	5922	4	concentration	concentration	NN
cord-006229-7yoilsho	5922	5	time	time	NN
cord-006229-7yoilsho	5922	6	profile	profile	NN
cord-006229-7yoilsho	5922	7	exploring	explore	VBG
cord-006229-7yoilsho	5922	8	the	the	DT
cord-006229-7yoilsho	5922	9	dose	dose	NN
cord-006229-7yoilsho	5922	10	which	which	WDT
cord-006229-7yoilsho	5922	11	would	would	MD
cord-006229-7yoilsho	5922	12	lead	lead	VB
cord-006229-7yoilsho	5922	13	to	to	IN
cord-006229-7yoilsho	5922	14	a	a	DT
cord-006229-7yoilsho	5922	15	concentration	concentration	NN
cord-006229-7yoilsho	5922	16	at	at	IN
cord-006229-7yoilsho	5922	17	1	1	CD
cord-006229-7yoilsho	5922	18	hour	hour	NN
cord-006229-7yoilsho	5922	19	and	and	CC
cord-006229-7yoilsho	5922	20	at	at	IN
cord-006229-7yoilsho	5922	21	24	24	CD
cord-006229-7yoilsho	5922	22	hour	hour	NN
cord-006229-7yoilsho	5922	23	as	as	RB
cord-006229-7yoilsho	5922	24	similar	similar	JJ
cord-006229-7yoilsho	5922	25	as	as	IN
cord-006229-7yoilsho	5922	26	possible	possible	JJ
cord-006229-7yoilsho	5922	27	to	to	IN
cord-006229-7yoilsho	5922	28	the	the	DT
cord-006229-7yoilsho	5922	29	concentration	concentration	NN
cord-006229-7yoilsho	5922	30	measured	measure	VBN
cord-006229-7yoilsho	5922	31	in	in	IN
cord-006229-7yoilsho	5922	32	the	the	DT
cord-006229-7yoilsho	5922	33	supernatant	supernatant	NN
cord-006229-7yoilsho	5922	34	of	of	IN
cord-006229-7yoilsho	5922	35	human	human	JJ
cord-006229-7yoilsho	5922	36	freshly	freshly	RB
cord-006229-7yoilsho	5922	37	prepared	prepared	JJ
cord-006229-7yoilsho	5922	38	cell	cell	NN
cord-006229-7yoilsho	5922	39	cultures	culture	NNS
cord-006229-7yoilsho	5922	40	after	after	IN
cord-006229-7yoilsho	5922	41	dosing	dose	VBG
cord-006229-7yoilsho	5922	42	the	the	DT
cord-006229-7yoilsho	5922	43	culture	culture	NN
cord-006229-7yoilsho	5922	44	with	with	IN
cord-006229-7yoilsho	5922	45	ibuprofen	ibuprofen	NN
cord-006229-7yoilsho	5922	46	.	.	.
cord-006229-7yoilsho	5923	1	We	-PRON-	PRP
cord-006229-7yoilsho	5923	2	parametrized	parametrize	VBD
cord-006229-7yoilsho	5923	3	the	the	DT
cord-006229-7yoilsho	5923	4	PBHKM	PBHKM	NNP
cord-006229-7yoilsho	5923	5	with	with	IN
cord-006229-7yoilsho	5923	6	the	the	DT
cord-006229-7yoilsho	5923	7	parameters	parameter	NNS
cord-006229-7yoilsho	5923	8	which	which	WDT
cord-006229-7yoilsho	5923	9	have	have	VBP
cord-006229-7yoilsho	5923	10	been	be	VBN
cord-006229-7yoilsho	5923	11	estimated	estimate	VBN
cord-006229-7yoilsho	5923	12	from	from	IN
cord-006229-7yoilsho	5923	13	the	the	DT
cord-006229-7yoilsho	5923	14	in	in	FW
cord-006229-7yoilsho	5923	15	vitro	vitro	FW
cord-006229-7yoilsho	5923	16	kinetic	kinetic	JJ
cord-006229-7yoilsho	5923	17	studies	study	NNS
cord-006229-7yoilsho	5923	18	(	(	-LRB-
cord-006229-7yoilsho	5923	19	clearance	clearance	NN
cord-006229-7yoilsho	5923	20	between	between	IN
cord-006229-7yoilsho	5923	21	3	3	CD
cord-006229-7yoilsho	5923	22	and	and	CC
cord-006229-7yoilsho	5923	23	15	15	CD
cord-006229-7yoilsho	5923	24	µm	µm	CD
cord-006229-7yoilsho	5923	25	3	3	CD
cord-006229-7yoilsho	5923	26	/sec	/sec	.
cord-006229-7yoilsho	5924	1	(	(	-LRB-
cord-006229-7yoilsho	5924	2	Truisi	Truisi	NNP
cord-006229-7yoilsho	5924	3	et	et	NNP
cord-006229-7yoilsho	5924	4	al	al	NNP
cord-006229-7yoilsho	5924	5	.	.	NNP
cord-006229-7yoilsho	5924	6	,	,	,
cord-006229-7yoilsho	5924	7	2015	2015	CD
cord-006229-7yoilsho	5924	8	)	)	-RRB-
cord-006229-7yoilsho	5924	9	and	and	CC
cord-006229-7yoilsho	5924	10	an	an	DT
cord-006229-7yoilsho	5924	11	absorption	absorption	NN
cord-006229-7yoilsho	5924	12	of	of	IN
cord-006229-7yoilsho	5924	13	100	100	CD
cord-006229-7yoilsho	5924	14	%	%	NN
cord-006229-7yoilsho	5924	15	and	and	CC
cord-006229-7yoilsho	5924	16	an	an	DT
cord-006229-7yoilsho	5924	17	absorption	absorption	NN
cord-006229-7yoilsho	5924	18	rate	rate	NN
cord-006229-7yoilsho	5924	19	of	of	IN
cord-006229-7yoilsho	5924	20	1	1	CD
cord-006229-7yoilsho	5924	21	/	/	SYM
cord-006229-7yoilsho	5924	22	h	h	NN
cord-006229-7yoilsho	5924	23	(	(	-LRB-
cord-006229-7yoilsho	5924	24	Cristofoletti	Cristofoletti	NNP
cord-006229-7yoilsho	5924	25	and	and	CC
cord-006229-7yoilsho	5924	26	Dressman	Dressman	NNP
cord-006229-7yoilsho	5924	27	,	,	,
cord-006229-7yoilsho	5924	28	J	J	NNP
cord-006229-7yoilsho	5924	29	Pharm	Pharm	NNP
cord-006229-7yoilsho	5924	30	Sci	Sci	NNP
cord-006229-7yoilsho	5924	31	103	103	CD
cord-006229-7yoilsho	5924	32	:	:	:
cord-006229-7yoilsho	5924	33	3263	3263	CD
cord-006229-7yoilsho	5924	34	-	-	HYPH
cord-006229-7yoilsho	5924	35	75	75	CD
cord-006229-7yoilsho	5924	36	,	,	,
cord-006229-7yoilsho	5924	37	2014	2014	CD
cord-006229-7yoilsho	5924	38	)	)	-RRB-
cord-006229-7yoilsho	5924	39	.	.	.
cord-006229-7yoilsho	5925	1	Results	result	NNS
cord-006229-7yoilsho	5925	2	:	:	:
cord-006229-7yoilsho	5926	1	The	the	DT
cord-006229-7yoilsho	5926	2	data	datum	NNS
cord-006229-7yoilsho	5926	3	of	of	IN
cord-006229-7yoilsho	5926	4	the	the	DT
cord-006229-7yoilsho	5926	5	in	in	FW
cord-006229-7yoilsho	5926	6	vitro	vitro	FW
cord-006229-7yoilsho	5926	7	study	study	NN
cord-006229-7yoilsho	5926	8	with	with	IN
cord-006229-7yoilsho	5926	9	100	100	CD
cord-006229-7yoilsho	5926	10	µM	µm	CD
cord-006229-7yoilsho	5926	11	ibuprofen	ibuprofen	NN
cord-006229-7yoilsho	5926	12	could	could	MD
cord-006229-7yoilsho	5926	13	well	well	RB
cord-006229-7yoilsho	5926	14	be	be	VB
cord-006229-7yoilsho	5926	15	modelled	model	VBN
cord-006229-7yoilsho	5926	16	.	.	.
cord-006229-7yoilsho	5927	1	When	when	WRB
cord-006229-7yoilsho	5927	2	assuming	assume	VBG
cord-006229-7yoilsho	5927	3	a	a	DT
cord-006229-7yoilsho	5927	4	clearance	clearance	NN
cord-006229-7yoilsho	5927	5	of	of	IN
cord-006229-7yoilsho	5927	6	15	15	CD
cord-006229-7yoilsho	5927	7	µm	µm	CD
cord-006229-7yoilsho	5927	8	3	3	CD
cord-006229-7yoilsho	5927	9	/sec	/sec	.
cord-006229-7yoilsho	5928	1	the	the	DT
cord-006229-7yoilsho	5928	2	dose	dose	NN
cord-006229-7yoilsho	5928	3	of	of	IN
cord-006229-7yoilsho	5928	4	1480	1480	CD
cord-006229-7yoilsho	5928	5	mg	mg	NNS
cord-006229-7yoilsho	5928	6	resulted	result	VBD
cord-006229-7yoilsho	5928	7	in	in	IN
cord-006229-7yoilsho	5928	8	an	an	DT
cord-006229-7yoilsho	5928	9	1	1	CD
cord-006229-7yoilsho	5928	10	hour	hour	NN
cord-006229-7yoilsho	5928	11	concentration	concentration	NN
cord-006229-7yoilsho	5928	12	of	of	IN
cord-006229-7yoilsho	5928	13	66.5	66.5	CD
cord-006229-7yoilsho	5928	14	µM	µM	NFP
cord-006229-7yoilsho	5928	15	in	in	IN
cord-006229-7yoilsho	5928	16	the	the	DT
cord-006229-7yoilsho	5928	17	hepatic	hepatic	JJ
cord-006229-7yoilsho	5928	18	vein	vein	NN
cord-006229-7yoilsho	5928	19	of	of	IN
cord-006229-7yoilsho	5928	20	PBHKM	PBHKM	NNP
cord-006229-7yoilsho	5928	21	equal	equal	JJ
cord-006229-7yoilsho	5928	22	to	to	IN
cord-006229-7yoilsho	5928	23	133.0	133.0	CD
cord-006229-7yoilsho	5928	24	nmol/	nmol/	CD
cord-006229-7yoilsho	5929	1	well	well	UH
cord-006229-7yoilsho	5929	2	(	(	-LRB-
cord-006229-7yoilsho	5929	3	volume	volume	NN
cord-006229-7yoilsho	5929	4	of	of	IN
cord-006229-7yoilsho	5929	5	the	the	DT
cord-006229-7yoilsho	5929	6	well	well	NN
cord-006229-7yoilsho	5929	7	=	=	SYM
cord-006229-7yoilsho	5929	8	2	2	CD
cord-006229-7yoilsho	5929	9	ml	ml	NN
cord-006229-7yoilsho	5929	10	)	)	-RRB-
cord-006229-7yoilsho	5929	11	in	in	IN
cord-006229-7yoilsho	5929	12	the	the	DT
cord-006229-7yoilsho	5929	13	in	in	FW
cord-006229-7yoilsho	5929	14	vitro	vitro	FW
cord-006229-7yoilsho	5929	15	study	study	NN
cord-006229-7yoilsho	5929	16	in	in	IN
cord-006229-7yoilsho	5929	17	which	which	WDT
cord-006229-7yoilsho	5929	18	the	the	DT
cord-006229-7yoilsho	5929	19	measured	measure	VBN
cord-006229-7yoilsho	5929	20	concentration	concentration	NN
cord-006229-7yoilsho	5929	21	was	be	VBD
cord-006229-7yoilsho	5929	22	138.75	138.75	CD
cord-006229-7yoilsho	5929	23	nmol	nmol	JJ
cord-006229-7yoilsho	5929	24	/	/	SYM
cord-006229-7yoilsho	5929	25	well	well	UH
cord-006229-7yoilsho	5929	26	.	.	.
cord-006229-7yoilsho	5930	1	The	the	DT
cord-006229-7yoilsho	5930	2	concentration	concentration	NN
cord-006229-7yoilsho	5930	3	at	at	IN
cord-006229-7yoilsho	5930	4	24	24	CD
cord-006229-7yoilsho	5930	5	hours	hour	NNS
cord-006229-7yoilsho	5930	6	of	of	IN
cord-006229-7yoilsho	5930	7	8.7	8.7	CD
cord-006229-7yoilsho	5930	8	µM	µM	NFP
cord-006229-7yoilsho	5930	9	(	(	-LRB-
cord-006229-7yoilsho	5930	10	equal	equal	JJ
cord-006229-7yoilsho	5930	11	to	to	IN
cord-006229-7yoilsho	5930	12	17.4	17.4	CD
cord-006229-7yoilsho	5930	13	nmol	nmol	NN
cord-006229-7yoilsho	5930	14	/	/	SYM
cord-006229-7yoilsho	5930	15	well	well	RB
cord-006229-7yoilsho	5930	16	)	)	-RRB-
cord-006229-7yoilsho	5930	17	corresponded	correspond	VBD
cord-006229-7yoilsho	5930	18	with	with	IN
cord-006229-7yoilsho	5930	19	the	the	DT
cord-006229-7yoilsho	5930	20	in	in	FW
cord-006229-7yoilsho	5930	21	vitro	vitro	FW
cord-006229-7yoilsho	5930	22	concentration	concentration	NN
cord-006229-7yoilsho	5930	23	(	(	-LRB-
cord-006229-7yoilsho	5930	24	16.5	16.5	CD
cord-006229-7yoilsho	5930	25	nmol	nmol	JJ
cord-006229-7yoilsho	5930	26	/	/	SYM
cord-006229-7yoilsho	5930	27	well	well	RB
cord-006229-7yoilsho	5930	28	)	)	-RRB-
cord-006229-7yoilsho	5930	29	.	.	.
cord-006229-7yoilsho	5931	1	The	the	DT
cord-006229-7yoilsho	5931	2	modelling	modelling	NN
cord-006229-7yoilsho	5931	3	approach	approach	NN
cord-006229-7yoilsho	5931	4	was	be	VBD
cord-006229-7yoilsho	5931	5	less	less	RBR
cord-006229-7yoilsho	5931	6	successful	successful	JJ
cord-006229-7yoilsho	5931	7	with	with	IN
cord-006229-7yoilsho	5931	8	in	in	FW
cord-006229-7yoilsho	5931	9	vitro	vitro	FW
cord-006229-7yoilsho	5931	10	dosing	dosing	NN
cord-006229-7yoilsho	5931	11	of	of	IN
cord-006229-7yoilsho	5931	12	1000	1000	CD
cord-006229-7yoilsho	5932	1	µM.	µM.	NNP
cord-006229-7yoilsho	5933	1	The	the	DT
cord-006229-7yoilsho	5933	2	10	10	CD
cord-006229-7yoilsho	5933	3	fold	fold	VBP
cord-006229-7yoilsho	5933	4	higher	high	JJR
cord-006229-7yoilsho	5933	5	dose	dose	NN
cord-006229-7yoilsho	5933	6	of	of	IN
cord-006229-7yoilsho	5933	7	14800	14800	CD
cord-006229-7yoilsho	5933	8	mg	mg	CD
cord-006229-7yoilsho	5933	9	lead	lead	NN
cord-006229-7yoilsho	5933	10	to	to	IN
cord-006229-7yoilsho	5933	11	nearly	nearly	RB
cord-006229-7yoilsho	5933	12	double	double	PDT
cord-006229-7yoilsho	5933	13	the	the	DT
cord-006229-7yoilsho	5933	14	concentration	concentration	NN
cord-006229-7yoilsho	5933	15	at	at	IN
cord-006229-7yoilsho	5933	16	1	1	CD
cord-006229-7yoilsho	5933	17	hour	hour	NN
cord-006229-7yoilsho	5933	18	than	than	IN
cord-006229-7yoilsho	5933	19	measured	measure	VBN
cord-006229-7yoilsho	5933	20	in	in	IN
cord-006229-7yoilsho	5933	21	vitro	vitro	FW
cord-006229-7yoilsho	5933	22	.	.	.
cord-006229-7yoilsho	5934	1	With	with	IN
cord-006229-7yoilsho	5934	2	a	a	DT
cord-006229-7yoilsho	5934	3	dose	dose	NN
cord-006229-7yoilsho	5934	4	of	of	IN
cord-006229-7yoilsho	5934	5	8500	8500	CD
cord-006229-7yoilsho	5934	6	mg	mg	NNP
cord-006229-7yoilsho	5934	7	/	/	SYM
cord-006229-7yoilsho	5934	8	kg	kg	VBZ
cord-006229-7yoilsho	5934	9	an	an	DT
cord-006229-7yoilsho	5934	10	approximation	approximation	NN
cord-006229-7yoilsho	5934	11	was	be	VBD
cord-006229-7yoilsho	5934	12	feasible	feasible	JJ
cord-006229-7yoilsho	5934	13	resulting	result	VBG
cord-006229-7yoilsho	5934	14	in	in	IN
cord-006229-7yoilsho	5934	15	396.7	396.7	CD
cord-006229-7yoilsho	5934	16	µM	µM	NFP
cord-006229-7yoilsho	5934	17	in	in	IN
cord-006229-7yoilsho	5934	18	the	the	DT
cord-006229-7yoilsho	5934	19	hepatic	hepatic	JJ
cord-006229-7yoilsho	5934	20	vein	vein	NN
cord-006229-7yoilsho	5934	21	at	at	IN
cord-006229-7yoilsho	5934	22	1	1	CD
cord-006229-7yoilsho	5934	23	hour	hour	NN
cord-006229-7yoilsho	5934	24	which	which	WDT
cord-006229-7yoilsho	5934	25	is	be	VBZ
cord-006229-7yoilsho	5934	26	equal	equal	JJ
cord-006229-7yoilsho	5934	27	to	to	IN
cord-006229-7yoilsho	5934	28	793.4	793.4	CD
cord-006229-7yoilsho	5934	29	nmol	nmol	NN
cord-006229-7yoilsho	5934	30	/	/	,
cord-006229-7yoilsho	5934	31	well	well	RB
cord-006229-7yoilsho	5934	32	whereas	whereas	IN
cord-006229-7yoilsho	5934	33	the	the	DT
cord-006229-7yoilsho	5934	34	measured	measure	VBN
cord-006229-7yoilsho	5934	35	concentration	concentration	NN
cord-006229-7yoilsho	5934	36	in	in	IN
cord-006229-7yoilsho	5934	37	vitro	vitro	FW
cord-006229-7yoilsho	5934	38	was	be	VBD
cord-006229-7yoilsho	5934	39	782.85	782.85	CD
cord-006229-7yoilsho	5934	40	nmol	nmol	JJ
cord-006229-7yoilsho	5934	41	/	/	SYM
cord-006229-7yoilsho	5934	42	well	well	UH
cord-006229-7yoilsho	5934	43	.	.	.
cord-006229-7yoilsho	5935	1	Even	even	RB
cord-006229-7yoilsho	5935	2	with	with	IN
cord-006229-7yoilsho	5935	3	a	a	DT
cord-006229-7yoilsho	5935	4	clearance	clearance	NN
cord-006229-7yoilsho	5935	5	value	value	NN
cord-006229-7yoilsho	5935	6	as	as	RB
cord-006229-7yoilsho	5935	7	low	low	JJ
cord-006229-7yoilsho	5935	8	as	as	IN
cord-006229-7yoilsho	5935	9	the	the	DT
cord-006229-7yoilsho	5935	10	2.5	2.5	CD
cord-006229-7yoilsho	5935	11	percentile	percentile	NN
cord-006229-7yoilsho	5935	12	(	(	-LRB-
cord-006229-7yoilsho	5935	13	3	3	CD
cord-006229-7yoilsho	5935	14	µm	µm	CD
cord-006229-7yoilsho	5935	15	3	3	CD
cord-006229-7yoilsho	5935	16	/sec	/sec	NFP
cord-006229-7yoilsho	5935	17	)	)	-RRB-
cord-006229-7yoilsho	5935	18	,	,	,
cord-006229-7yoilsho	5935	19	the	the	DT
cord-006229-7yoilsho	5935	20	concentration	concentration	NN
cord-006229-7yoilsho	5935	21	at	at	IN
cord-006229-7yoilsho	5935	22	24	24	CD
cord-006229-7yoilsho	5935	23	hours	hour	NNS
cord-006229-7yoilsho	5935	24	was	be	VBD
cord-006229-7yoilsho	5935	25	modelled	model	VBN
cord-006229-7yoilsho	5935	26	to	to	TO
cord-006229-7yoilsho	5935	27	be	be	VB
cord-006229-7yoilsho	5935	28	lower	low	JJR
cord-006229-7yoilsho	5935	29	than	than	IN
cord-006229-7yoilsho	5935	30	the	the	DT
cord-006229-7yoilsho	5935	31	in	in	FW
cord-006229-7yoilsho	5935	32	vitro	vitro	FW
cord-006229-7yoilsho	5935	33	measured	measure	VBN
cord-006229-7yoilsho	5935	34	value	value	NN
cord-006229-7yoilsho	5935	35	(	(	-LRB-
cord-006229-7yoilsho	5935	36	in	in	IN
cord-006229-7yoilsho	5935	37	vivo	vivo	NN
cord-006229-7yoilsho	5935	38	model	model	NN
cord-006229-7yoilsho	5935	39	:	:	:
cord-006229-7yoilsho	5936	1	98.7	98.7	NNP
cord-006229-7yoilsho	5936	2	µM	µM	NNP
cord-006229-7yoilsho	5936	3	which	which	WDT
cord-006229-7yoilsho	5936	4	corresponds	correspond	VBZ
cord-006229-7yoilsho	5936	5	to	to	IN
cord-006229-7yoilsho	5936	6	197.4	197.4	CD
cord-006229-7yoilsho	5936	7	nmol	nmol	NN
cord-006229-7yoilsho	5936	8	/	/	SYM
cord-006229-7yoilsho	5936	9	well	well	UH
cord-006229-7yoilsho	5937	1	;	;	:
cord-006229-7yoilsho	5937	2	measured	measure	VBN
cord-006229-7yoilsho	5937	3	in	in	IN
cord-006229-7yoilsho	5937	4	vitro	vitro	FW
cord-006229-7yoilsho	5937	5	concentration	concentration	NN
cord-006229-7yoilsho	5937	6	:	:	:
cord-006229-7yoilsho	5938	1	979.2	979.2	CD
cord-006229-7yoilsho	5938	2	nmol	nmol	JJ
cord-006229-7yoilsho	5938	3	/	/	SYM
cord-006229-7yoilsho	5938	4	well	well	RB
cord-006229-7yoilsho	5938	5	)	)	-RRB-
cord-006229-7yoilsho	5938	6	.	.	.
cord-006229-7yoilsho	5939	1	Discussion	discussion	NN
cord-006229-7yoilsho	5939	2	:	:	:
cord-006229-7yoilsho	5940	1	This	this	DT
cord-006229-7yoilsho	5940	2	is	be	VBZ
cord-006229-7yoilsho	5940	3	the	the	DT
cord-006229-7yoilsho	5940	4	first	first	JJ
cord-006229-7yoilsho	5940	5	attempt	attempt	NN
cord-006229-7yoilsho	5940	6	to	to	TO
cord-006229-7yoilsho	5940	7	use	use	VB
cord-006229-7yoilsho	5940	8	kinetic	kinetic	JJ
cord-006229-7yoilsho	5940	9	data	datum	NNS
cord-006229-7yoilsho	5940	10	obtained	obtain	VBN
cord-006229-7yoilsho	5940	11	in	in	IN
cord-006229-7yoilsho	5940	12	vitro	vitro	FW
cord-006229-7yoilsho	5940	13	to	to	TO
cord-006229-7yoilsho	5940	14	feed	feed	VB
cord-006229-7yoilsho	5940	15	in	in	RP
cord-006229-7yoilsho	5940	16	in	in	IN
cord-006229-7yoilsho	5940	17	a	a	DT
cord-006229-7yoilsho	5940	18	PBHKM	PBHKM	NNP
cord-006229-7yoilsho	5940	19	for	for	IN
cord-006229-7yoilsho	5940	20	reverse	reverse	JJ
cord-006229-7yoilsho	5940	21	dosimetry	dosimetry	NN
cord-006229-7yoilsho	5940	22	finding	find	VBG
cord-006229-7yoilsho	5940	23	the	the	DT
cord-006229-7yoilsho	5940	24	dose	dose	NN
cord-006229-7yoilsho	5940	25	which	which	WDT
cord-006229-7yoilsho	5940	26	corresponds	correspond	VBZ
cord-006229-7yoilsho	5940	27	in	in	IN
cord-006229-7yoilsho	5940	28	vivo	vivo	NN
cord-006229-7yoilsho	5940	29	to	to	IN
cord-006229-7yoilsho	5940	30	the	the	DT
cord-006229-7yoilsho	5940	31	in	in	FW
cord-006229-7yoilsho	5940	32	vitro	vitro	FW
cord-006229-7yoilsho	5940	33	situation	situation	NN
cord-006229-7yoilsho	5940	34	.	.	.
cord-006229-7yoilsho	5941	1	In	in	IN
cord-006229-7yoilsho	5941	2	the	the	DT
cord-006229-7yoilsho	5941	3	case	case	NN
cord-006229-7yoilsho	5941	4	presented	present	VBN
cord-006229-7yoilsho	5941	5	here	here	RB
cord-006229-7yoilsho	5941	6	,	,	,
cord-006229-7yoilsho	5941	7	the	the	DT
cord-006229-7yoilsho	5941	8	in	in	FW
cord-006229-7yoilsho	5941	9	vitro	vitro	FW
cord-006229-7yoilsho	5941	10	dose	dose	NN
cord-006229-7yoilsho	5941	11	assumed	assume	VBN
cord-006229-7yoilsho	5941	12	to	to	TO
cord-006229-7yoilsho	5941	13	be	be	VB
cord-006229-7yoilsho	5941	14	low	low	JJ
cord-006229-7yoilsho	5941	15	in	in	IN
cord-006229-7yoilsho	5941	16	vitro	vitro	FW
cord-006229-7yoilsho	5941	17	(	(	-LRB-
cord-006229-7yoilsho	5941	18	100	100	CD
cord-006229-7yoilsho	5941	19	µM	µm	NN
cord-006229-7yoilsho	5941	20	)	)	-RRB-
cord-006229-7yoilsho	5941	21	corresponds	correspond	VBZ
cord-006229-7yoilsho	5941	22	to	to	IN
cord-006229-7yoilsho	5941	23	a	a	DT
cord-006229-7yoilsho	5941	24	dose	dose	NN
cord-006229-7yoilsho	5941	25	of	of	IN
cord-006229-7yoilsho	5941	26	1480	1480	CD
cord-006229-7yoilsho	5941	27	mg	mg	NN
cord-006229-7yoilsho	5941	28	(	(	-LRB-
cord-006229-7yoilsho	5941	29	note	note	NN
cord-006229-7yoilsho	5941	30	:	:	:
cord-006229-7yoilsho	5941	31	the	the	DT
cord-006229-7yoilsho	5941	32	highest	high	JJS
cord-006229-7yoilsho	5941	33	approved	approve	VBN
cord-006229-7yoilsho	5941	34	daily	daily	JJ
cord-006229-7yoilsho	5941	35	dose	dose	NN
cord-006229-7yoilsho	5941	36	is	be	VBZ
cord-006229-7yoilsho	5941	37	2,400	2,400	CD
cord-006229-7yoilsho	5941	38	mg	mg	NNP
cord-006229-7yoilsho	5941	39	)	)	-RRB-
cord-006229-7yoilsho	5941	40	.	.	.
cord-006229-7yoilsho	5942	1	For	for	IN
cord-006229-7yoilsho	5942	2	the	the	DT
cord-006229-7yoilsho	5942	3	high	high	JJ
cord-006229-7yoilsho	5942	4	in	in	IN
cord-006229-7yoilsho	5942	5	vitro	vitro	FW
cord-006229-7yoilsho	5942	6	dose	dose	NN
cord-006229-7yoilsho	5942	7	modelling	modelling	NN
cord-006229-7yoilsho	5942	8	was	be	VBD
cord-006229-7yoilsho	5942	9	successful	successful	JJ
cord-006229-7yoilsho	5942	10	only	only	RB
cord-006229-7yoilsho	5942	11	for	for	IN
cord-006229-7yoilsho	5942	12	the	the	DT
cord-006229-7yoilsho	5942	13	concentration	concentration	NN
cord-006229-7yoilsho	5942	14	1	1	CD
cord-006229-7yoilsho	5942	15	hour	hour	NN
cord-006229-7yoilsho	5942	16	after	after	IN
cord-006229-7yoilsho	5942	17	dosing	dosing	NN
cord-006229-7yoilsho	5942	18	and	and	CC
cord-006229-7yoilsho	5942	19	a	a	DT
cord-006229-7yoilsho	5942	20	dose	dose	NN
cord-006229-7yoilsho	5942	21	of	of	IN
cord-006229-7yoilsho	5942	22	8,500	8,500	CD
cord-006229-7yoilsho	5942	23	mg	mg	NN
cord-006229-7yoilsho	5942	24	.	.	.
cord-006229-7yoilsho	5943	1	Conclusions	conclusion	NNS
cord-006229-7yoilsho	5943	2	:	:	:
cord-006229-7yoilsho	5944	1	In	in	IN
cord-006229-7yoilsho	5944	2	vitro	vitro	FW
cord-006229-7yoilsho	5944	3	kinetic	kinetic	JJ
cord-006229-7yoilsho	5944	4	parameters	parameter	NNS
cord-006229-7yoilsho	5944	5	,	,	,
cord-006229-7yoilsho	5944	6	such	such	JJ
cord-006229-7yoilsho	5944	7	as	as	IN
cord-006229-7yoilsho	5944	8	clearance	clearance	NN
cord-006229-7yoilsho	5944	9	,	,	,
cord-006229-7yoilsho	5944	10	can	can	MD
cord-006229-7yoilsho	5944	11	successfully	successfully	RB
cord-006229-7yoilsho	5944	12	be	be	VB
cord-006229-7yoilsho	5944	13	used	use	VBN
cord-006229-7yoilsho	5944	14	for	for	IN
cord-006229-7yoilsho	5944	15	parametrizing	parametrize	VBG
cord-006229-7yoilsho	5944	16	a	a	DT
cord-006229-7yoilsho	5944	17	PBHKM	PBHKM	NNP
cord-006229-7yoilsho	5944	18	.	.	.
cord-006229-7yoilsho	5945	1	It	-PRON-	PRP
cord-006229-7yoilsho	5945	2	is	be	VBZ
cord-006229-7yoilsho	5945	3	of	of	IN
cord-006229-7yoilsho	5945	4	utmost	utmost	JJ
cord-006229-7yoilsho	5945	5	importance	importance	NN
cord-006229-7yoilsho	5945	6	for	for	IN
cord-006229-7yoilsho	5945	7	the	the	DT
cord-006229-7yoilsho	5945	8	relevance	relevance	NN
cord-006229-7yoilsho	5945	9	of	of	IN
cord-006229-7yoilsho	5945	10	in	in	FW
cord-006229-7yoilsho	5945	11	vitro	vitro	FW
cord-006229-7yoilsho	5945	12	finding	find	VBG
cord-006229-7yoilsho	5945	13	to	to	TO
cord-006229-7yoilsho	5945	14	assure	assure	VB
cord-006229-7yoilsho	5945	15	that	that	IN
cord-006229-7yoilsho	5945	16	the	the	DT
cord-006229-7yoilsho	5945	17	concentrations	concentration	NNS
cord-006229-7yoilsho	5945	18	used	use	VBN
cord-006229-7yoilsho	5945	19	in	in	IN
cord-006229-7yoilsho	5945	20	vitro	vitro	FW
cord-006229-7yoilsho	5945	21	can	can	MD
cord-006229-7yoilsho	5945	22	be	be	VB
cord-006229-7yoilsho	5945	23	obtained	obtain	VBN
cord-006229-7yoilsho	5945	24	with	with	IN
cord-006229-7yoilsho	5945	25	relevant	relevant	JJ
cord-006229-7yoilsho	5945	26	in	in	IN
cord-006229-7yoilsho	5945	27	vivo	vivo	NNP
cord-006229-7yoilsho	5945	28	doses	dose	NNS
cord-006229-7yoilsho	5945	29	.	.	.
cord-006229-7yoilsho	5946	1	In	in	IN
cord-006229-7yoilsho	5946	2	this	this	DT
cord-006229-7yoilsho	5946	3	case	case	NN
cord-006229-7yoilsho	5946	4	,	,	,
cord-006229-7yoilsho	5946	5	the	the	DT
cord-006229-7yoilsho	5946	6	in	in	FW
cord-006229-7yoilsho	5946	7	vitro	vitro	FW
cord-006229-7yoilsho	5946	8	concentrations	concentration	NNS
cord-006229-7yoilsho	5946	9	were	be	VBD
cord-006229-7yoilsho	5946	10	within	within	IN
cord-006229-7yoilsho	5946	11	(	(	-LRB-
cord-006229-7yoilsho	5946	12	low	low	JJ
cord-006229-7yoilsho	5946	13	dose	dose	NN
cord-006229-7yoilsho	5946	14	)	)	-RRB-
cord-006229-7yoilsho	5946	15	and	and	CC
cord-006229-7yoilsho	5946	16	3.5	3.5	CD
cord-006229-7yoilsho	5946	17	fold	fold	VB
cord-006229-7yoilsho	5946	18	above	above	RB
cord-006229-7yoilsho	5946	19	(	(	-LRB-
cord-006229-7yoilsho	5946	20	high	high	JJ
cord-006229-7yoilsho	5946	21	dose	dose	NN
cord-006229-7yoilsho	5946	22	)	)	-RRB-
cord-006229-7yoilsho	5946	23	the	the	DT
cord-006229-7yoilsho	5946	24	in	in	IN
cord-006229-7yoilsho	5946	25	vivo	vivo	FW
cord-006229-7yoilsho	5946	26	relevant	relevant	JJ
cord-006229-7yoilsho	5946	27	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	5946	28	concentration	concentration	NN
cord-006229-7yoilsho	5946	29	range	range	NN
cord-006229-7yoilsho	5946	30	.	.	.
cord-006229-7yoilsho	5947	1	Introduction	introduction	NN
cord-006229-7yoilsho	5947	2	:	:	:
cord-006229-7yoilsho	5948	1	A	a	DT
cord-006229-7yoilsho	5948	2	variety	variety	NN
cord-006229-7yoilsho	5948	3	of	of	IN
cord-006229-7yoilsho	5948	4	drug	drug	NN
cord-006229-7yoilsho	5948	5	residues	residue	NNS
cord-006229-7yoilsho	5948	6	have	have	VBP
cord-006229-7yoilsho	5948	7	been	be	VBN
cord-006229-7yoilsho	5948	8	detected	detect	VBN
cord-006229-7yoilsho	5948	9	in	in	IN
cord-006229-7yoilsho	5948	10	sewage	sewage	NN
cord-006229-7yoilsho	5948	11	plant	plant	NN
cord-006229-7yoilsho	5948	12	run	run	NN
cord-006229-7yoilsho	5948	13	-	-	HYPH
cord-006229-7yoilsho	5948	14	offs	off	NNS
cord-006229-7yoilsho	5948	15	,	,	,
cord-006229-7yoilsho	5948	16	rivers	river	NNS
cord-006229-7yoilsho	5948	17	and	and	CC
cord-006229-7yoilsho	5948	18	lakes	lake	NNS
cord-006229-7yoilsho	5948	19	,	,	,
cord-006229-7yoilsho	5948	20	but	but	CC
cord-006229-7yoilsho	5948	21	also	also	RB
cord-006229-7yoilsho	5948	22	in	in	IN
cord-006229-7yoilsho	5948	23	groundwater	groundwater	NN
cord-006229-7yoilsho	5948	24	and	and	CC
cord-006229-7yoilsho	5948	25	tap	tap	NN
cord-006229-7yoilsho	5948	26	water	water	NN
cord-006229-7yoilsho	5948	27	samples	sample	NNS
cord-006229-7yoilsho	5948	28	.	.	.
cord-006229-7yoilsho	5949	1	Studies	study	NNS
cord-006229-7yoilsho	5949	2	have	have	VBP
cord-006229-7yoilsho	5949	3	yet	yet	RB
cord-006229-7yoilsho	5949	4	to	to	TO
cord-006229-7yoilsho	5949	5	identify	identify	VB
cord-006229-7yoilsho	5949	6	a	a	DT
cord-006229-7yoilsho	5949	7	risk	risk	NN
cord-006229-7yoilsho	5949	8	for	for	IN
cord-006229-7yoilsho	5949	9	human	human	JJ
cord-006229-7yoilsho	5949	10	health	health	NN
cord-006229-7yoilsho	5949	11	from	from	IN
cord-006229-7yoilsho	5949	12	these	these	DT
cord-006229-7yoilsho	5949	13	contaminants	contaminant	NNS
cord-006229-7yoilsho	5949	14	,	,	,
cord-006229-7yoilsho	5949	15	but	but	CC
cord-006229-7yoilsho	5949	16	adverse	adverse	JJ
cord-006229-7yoilsho	5949	17	health	health	NN
cord-006229-7yoilsho	5949	18	effects	effect	NNS
cord-006229-7yoilsho	5949	19	have	have	VBP
cord-006229-7yoilsho	5949	20	been	be	VBN
cord-006229-7yoilsho	5949	21	reported	report	VBN
cord-006229-7yoilsho	5949	22	for	for	IN
cord-006229-7yoilsho	5949	23	various	various	JJ
cord-006229-7yoilsho	5949	24	species	specie	NNS
cord-006229-7yoilsho	5949	25	,	,	,
cord-006229-7yoilsho	5949	26	including	include	VBG
cord-006229-7yoilsho	5949	27	fish	fish	NN
cord-006229-7yoilsho	5949	28	and	and	CC
cord-006229-7yoilsho	5949	29	birds	bird	NNS
cord-006229-7yoilsho	5949	30	.	.	.
cord-006229-7yoilsho	5950	1	It	-PRON-	PRP
cord-006229-7yoilsho	5950	2	has	have	VBZ
cord-006229-7yoilsho	5950	3	recently	recently	RB
cord-006229-7yoilsho	5950	4	been	be	VBN
cord-006229-7yoilsho	5950	5	suggested	suggest	VBN
cord-006229-7yoilsho	5950	6	that	that	IN
cord-006229-7yoilsho	5950	7	for	for	IN
cord-006229-7yoilsho	5950	8	a	a	DT
cord-006229-7yoilsho	5950	9	comprehensive	comprehensive	JJ
cord-006229-7yoilsho	5950	10	risk	risk	NN
cord-006229-7yoilsho	5950	11	assessment	assessment	NN
cord-006229-7yoilsho	5950	12	toxicologists	toxicologist	NNS
cord-006229-7yoilsho	5950	13	should	should	MD
cord-006229-7yoilsho	5950	14	also	also	RB
cord-006229-7yoilsho	5950	15	consider	consider	VB
cord-006229-7yoilsho	5950	16	transformation	transformation	NN
cord-006229-7yoilsho	5950	17	products	product	NNS
cord-006229-7yoilsho	5950	18	(	(	-LRB-
cord-006229-7yoilsho	5950	19	TPs	TPs	NNP
cord-006229-7yoilsho	5950	20	)	)	-RRB-
cord-006229-7yoilsho	5950	21	of	of	IN
cord-006229-7yoilsho	5950	22	such	such	JJ
cord-006229-7yoilsho	5950	23	water	water	NN
cord-006229-7yoilsho	5950	24	contaminants	contaminant	NNS
cord-006229-7yoilsho	5950	25	that	that	WDT
cord-006229-7yoilsho	5950	26	may	may	MD
cord-006229-7yoilsho	5950	27	arise	arise	VB
cord-006229-7yoilsho	5950	28	from	from	IN
cord-006229-7yoilsho	5950	29	abiotic	abiotic	JJ
cord-006229-7yoilsho	5950	30	and	and	CC
cord-006229-7yoilsho	5950	31	biotic	biotic	JJ
cord-006229-7yoilsho	5950	32	(	(	-LRB-
cord-006229-7yoilsho	5950	33	metabolic	metabolic	JJ
cord-006229-7yoilsho	5950	34	)	)	-RRB-
cord-006229-7yoilsho	5950	35	reactions	reaction	NNS
cord-006229-7yoilsho	5950	36	.	.	.
cord-006229-7yoilsho	5951	1	With	with	IN
cord-006229-7yoilsho	5951	2	aciclovir	aciclovir	NNP
cord-006229-7yoilsho	5951	3	(	(	-LRB-
cord-006229-7yoilsho	5951	4	ACV	ACV	NNP
cord-006229-7yoilsho	5951	5	)	)	-RRB-
cord-006229-7yoilsho	5951	6	,	,	,
cord-006229-7yoilsho	5951	7	a	a	DT
cord-006229-7yoilsho	5951	8	well	well	RB
cord-006229-7yoilsho	5951	9	-	-	HYPH
cord-006229-7yoilsho	5951	10	known	know	VBN
cord-006229-7yoilsho	5951	11	antiviral	antiviral	JJ
cord-006229-7yoilsho	5951	12	drug	drug	NN
cord-006229-7yoilsho	5951	13	,	,	,
cord-006229-7yoilsho	5951	14	as	as	IN
cord-006229-7yoilsho	5951	15	the	the	DT
cord-006229-7yoilsho	5951	16	parent	parent	NN
cord-006229-7yoilsho	5951	17	drug	drug	NN
cord-006229-7yoilsho	5951	18	we	-PRON-	PRP
cord-006229-7yoilsho	5951	19	tried	try	VBD
cord-006229-7yoilsho	5951	20	an	an	DT
cord-006229-7yoilsho	5951	21	in	in	IN
cord-006229-7yoilsho	5951	22	-	-	HYPH
cord-006229-7yoilsho	5951	23	silico	silico	NN
cord-006229-7yoilsho	5951	24	approach	approach	NN
cord-006229-7yoilsho	5951	25	to	to	TO
cord-006229-7yoilsho	5951	26	identify	identify	VB
cord-006229-7yoilsho	5951	27	TPs	tp	NNS
cord-006229-7yoilsho	5951	28	that	that	WDT
cord-006229-7yoilsho	5951	29	might	may	MD
cord-006229-7yoilsho	5951	30	be	be	VB
cord-006229-7yoilsho	5951	31	of	of	IN
cord-006229-7yoilsho	5951	32	interest	interest	NN
cord-006229-7yoilsho	5951	33	due	due	JJ
cord-006229-7yoilsho	5951	34	to	to	IN
cord-006229-7yoilsho	5951	35	some	some	DT
cord-006229-7yoilsho	5951	36	mutagenic	mutagenic	JJ
cord-006229-7yoilsho	5951	37	or	or	CC
cord-006229-7yoilsho	5951	38	carcinogenic	carcinogenic	JJ
cord-006229-7yoilsho	5951	39	toxicophores	toxicophore	NNS
cord-006229-7yoilsho	5951	40	.	.	.
cord-006229-7yoilsho	5952	1	Methods	method	NNS
cord-006229-7yoilsho	5952	2	:	:	:
cord-006229-7yoilsho	5952	3	From	from	IN
cord-006229-7yoilsho	5952	4	a	a	DT
cord-006229-7yoilsho	5952	5	literature	literature	NN
cord-006229-7yoilsho	5952	6	and	and	CC
cord-006229-7yoilsho	5952	7	database	database	NN
cord-006229-7yoilsho	5952	8	search	search	NN
cord-006229-7yoilsho	5952	9	we	-PRON-	PRP
cord-006229-7yoilsho	5952	10	picked	pick	VBD
cord-006229-7yoilsho	5952	11	up	up	RP
cord-006229-7yoilsho	5952	12	12	12	CD
cord-006229-7yoilsho	5952	13	ACV	ACV	NNP
cord-006229-7yoilsho	5952	14	-	-	HYPH
cord-006229-7yoilsho	5952	15	TPs	tp	NNS
cord-006229-7yoilsho	5952	16	.	.	.
cord-006229-7yoilsho	5953	1	Predicted	predict	VBN
cord-006229-7yoilsho	5953	2	acute	acute	JJ
cord-006229-7yoilsho	5953	3	toxicities	toxicity	NNS
cord-006229-7yoilsho	5953	4	and	and	CC
cord-006229-7yoilsho	5953	5	mutagenic	mutagenic	JJ
cord-006229-7yoilsho	5953	6	/	/	SYM
cord-006229-7yoilsho	5953	7	carcinogenic	carcinogenic	JJ
cord-006229-7yoilsho	5953	8	properties	property	NNS
cord-006229-7yoilsho	5953	9	for	for	IN
cord-006229-7yoilsho	5953	10	these	these	DT
cord-006229-7yoilsho	5953	11	TPs	tp	NNS
cord-006229-7yoilsho	5953	12	were	be	VBD
cord-006229-7yoilsho	5953	13	derived	derive	VBN
cord-006229-7yoilsho	5953	14	from	from	IN
cord-006229-7yoilsho	5953	15	an	an	DT
cord-006229-7yoilsho	5953	16	expert	expert	NN
cord-006229-7yoilsho	5953	17	system	system	NN
cord-006229-7yoilsho	5953	18	analysis	analysis	NN
cord-006229-7yoilsho	5953	19	using	use	VBG
cord-006229-7yoilsho	5953	20	the	the	DT
cord-006229-7yoilsho	5953	21	LAZAR	LAZAR	NNP
cord-006229-7yoilsho	5953	22	portal	portal	NN
cord-006229-7yoilsho	5953	23	(	(	-LRB-
cord-006229-7yoilsho	5953	24	http://lazar.in-silico.ch/	http://lazar.in-silico.ch/	NNP
cord-006229-7yoilsho	5953	25	)	)	-RRB-
cord-006229-7yoilsho	5953	26	as	as	IN
cord-006229-7yoilsho	5953	27	front	front	JJ
cord-006229-7yoilsho	5953	28	end	end	NN
cord-006229-7yoilsho	5953	29	.	.	.
cord-006229-7yoilsho	5954	1	Results	result	NNS
cord-006229-7yoilsho	5954	2	:	:	:
cord-006229-7yoilsho	5955	1	Two	two	CD
cord-006229-7yoilsho	5955	2	of	of	IN
cord-006229-7yoilsho	5955	3	the	the	DT
cord-006229-7yoilsho	5955	4	identified	identify	VBN
cord-006229-7yoilsho	5955	5	ACV	ACV	NNP
cord-006229-7yoilsho	5955	6	-	-	HYPH
cord-006229-7yoilsho	5955	7	TPs	TPs	NNP
cord-006229-7yoilsho	5955	8	could	could	MD
cord-006229-7yoilsho	5955	9	not	not	RB
cord-006229-7yoilsho	5955	10	be	be	VB
cord-006229-7yoilsho	5955	11	handled	handle	VBN
cord-006229-7yoilsho	5955	12	by	by	IN
cord-006229-7yoilsho	5955	13	LAZAR	LAZAR	NNP
cord-006229-7yoilsho	5955	14	because	because	IN
cord-006229-7yoilsho	5955	15	of	of	IN
cord-006229-7yoilsho	5955	16	insufficient	insufficient	JJ
cord-006229-7yoilsho	5955	17	training	training	NN
cord-006229-7yoilsho	5955	18	data	datum	NNS
cord-006229-7yoilsho	5955	19	in	in	IN
cord-006229-7yoilsho	5955	20	one	one	CD
cord-006229-7yoilsho	5955	21	out	out	IN
cord-006229-7yoilsho	5955	22	of	of	IN
cord-006229-7yoilsho	5955	23	eight	eight	CD
cord-006229-7yoilsho	5955	24	queried	query	VBN
cord-006229-7yoilsho	5955	25	categories	category	NNS
cord-006229-7yoilsho	5955	26	.	.	.
cord-006229-7yoilsho	5956	1	The	the	DT
cord-006229-7yoilsho	5956	2	highest	high	JJS
cord-006229-7yoilsho	5956	3	score	score	NN
cord-006229-7yoilsho	5956	4	(	(	-LRB-
cord-006229-7yoilsho	5956	5	4	4	CD
cord-006229-7yoilsho	5956	6	positive	positive	JJ
cord-006229-7yoilsho	5956	7	out	out	IN
cord-006229-7yoilsho	5956	8	of	of	IN
cord-006229-7yoilsho	5956	9	8	8	CD
cord-006229-7yoilsho	5956	10	possible	possible	JJ
cord-006229-7yoilsho	5956	11	genotoxicity	genotoxicity	NN
cord-006229-7yoilsho	5956	12	categories	category	NNS
cord-006229-7yoilsho	5956	13	)	)	-RRB-
cord-006229-7yoilsho	5956	14	was	be	VBD
cord-006229-7yoilsho	5956	15	assigned	assign	VBN
cord-006229-7yoilsho	5956	16	to	to	IN
cord-006229-7yoilsho	5956	17	9	9	CD
cord-006229-7yoilsho	5956	18	of	of	IN
cord-006229-7yoilsho	5956	19	the	the	DT
cord-006229-7yoilsho	5956	20	12	12	CD
cord-006229-7yoilsho	5956	21	TPs	tp	NNS
cord-006229-7yoilsho	5956	22	,	,	,
cord-006229-7yoilsho	5956	23	including	include	VBG
cord-006229-7yoilsho	5956	24	ACV	ACV	NNP
cord-006229-7yoilsho	5956	25	itself	-PRON-	PRP
cord-006229-7yoilsho	5956	26	.	.	.
cord-006229-7yoilsho	5957	1	This	this	DT
cord-006229-7yoilsho	5957	2	is	be	VBZ
cord-006229-7yoilsho	5957	3	a	a	DT
cord-006229-7yoilsho	5957	4	rather	rather	RB
cord-006229-7yoilsho	5957	5	low	low	JJ
cord-006229-7yoilsho	5957	6	score	score	NN
cord-006229-7yoilsho	5957	7	when	when	WRB
cord-006229-7yoilsho	5957	8	compared	compare	VBN
cord-006229-7yoilsho	5957	9	to	to	IN
cord-006229-7yoilsho	5957	10	other	other	JJ
cord-006229-7yoilsho	5957	11	water	water	NN
cord-006229-7yoilsho	5957	12	-	-	HYPH
cord-006229-7yoilsho	5957	13	borne	bear	VBN
cord-006229-7yoilsho	5957	14	drug	drug	NN
cord-006229-7yoilsho	5957	15	residues	residue	NNS
cord-006229-7yoilsho	5957	16	,	,	,
cord-006229-7yoilsho	5957	17	e.g.	e.g.	RB
cord-006229-7yoilsho	5957	18	carbamazepine	carbamazepine	NN
cord-006229-7yoilsho	5957	19	.	.	.
cord-006229-7yoilsho	5958	1	COFA	COFA	NNP
cord-006229-7yoilsho	5958	2	,	,	,
cord-006229-7yoilsho	5958	3	an	an	DT
cord-006229-7yoilsho	5958	4	imidazole	imidazole	JJ
cord-006229-7yoilsho	5958	5	derivative	derivative	NN
cord-006229-7yoilsho	5958	6	of	of	IN
cord-006229-7yoilsho	5958	7	ACV	ACV	NNP
cord-006229-7yoilsho	5958	8	seen	see	VBN
cord-006229-7yoilsho	5958	9	in	in	IN
cord-006229-7yoilsho	5958	10	advanced	advanced	JJ
cord-006229-7yoilsho	5958	11	oxidation	oxidation	NN
cord-006229-7yoilsho	5958	12	processes	process	NNS
cord-006229-7yoilsho	5958	13	,	,	,
cord-006229-7yoilsho	5958	14	had	have	VBD
cord-006229-7yoilsho	5958	15	shown	show	VBN
cord-006229-7yoilsho	5958	16	antiproliferative	antiproliferative	JJ
cord-006229-7yoilsho	5958	17	effects	effect	NNS
cord-006229-7yoilsho	5958	18	in	in	IN
cord-006229-7yoilsho	5958	19	several	several	JJ
cord-006229-7yoilsho	5958	20	ecotoxicologic	ecotoxicologic	NN
cord-006229-7yoilsho	5958	21	screening	screening	NN
cord-006229-7yoilsho	5958	22	assays	assay	NNS
cord-006229-7yoilsho	5958	23	,	,	,
cord-006229-7yoilsho	5958	24	e.g.	e.g.	RB
cord-006229-7yoilsho	5958	25	[	[	-LRB-
cord-006229-7yoilsho	5958	26	1	1	CD
cord-006229-7yoilsho	5958	27	]	]	-RRB-
cord-006229-7yoilsho	5958	28	,	,	,
cord-006229-7yoilsho	5958	29	but	but	CC
cord-006229-7yoilsho	5958	30	was	be	VBD
cord-006229-7yoilsho	5958	31	unremarkable	unremarkable	JJ
cord-006229-7yoilsho	5958	32	in	in	IN
cord-006229-7yoilsho	5958	33	our	-PRON-	PRP$
cord-006229-7yoilsho	5958	34	tests	test	NNS
cord-006229-7yoilsho	5958	35	.	.	.
cord-006229-7yoilsho	5959	1	Additionally	additionally	RB
cord-006229-7yoilsho	5959	2	,	,	,
cord-006229-7yoilsho	5959	3	a	a	DT
cord-006229-7yoilsho	5959	4	computer	computer	NN
cord-006229-7yoilsho	5959	5	-	-	HYPH
cord-006229-7yoilsho	5959	6	based	base	VBN
cord-006229-7yoilsho	5959	7	simulation	simulation	NN
cord-006229-7yoilsho	5959	8	of	of	IN
cord-006229-7yoilsho	5959	9	the	the	DT
cord-006229-7yoilsho	5959	10	respective	respective	JJ
cord-006229-7yoilsho	5959	11	TPs	tp	NNS
cord-006229-7yoilsho	5959	12	interacting	interact	VBG
cord-006229-7yoilsho	5959	13	with	with	IN
cord-006229-7yoilsho	5959	14	human	human	JJ
cord-006229-7yoilsho	5959	15	CYP	CYP	NNP
cord-006229-7yoilsho	5959	16	isozymes	isozyme	NNS
cord-006229-7yoilsho	5959	17	did	do	VBD
cord-006229-7yoilsho	5959	18	not	not	RB
cord-006229-7yoilsho	5959	19	support	support	VB
cord-006229-7yoilsho	5959	20	concerns	concern	NNS
cord-006229-7yoilsho	5959	21	that	that	IN
cord-006229-7yoilsho	5959	22	these	these	DT
cord-006229-7yoilsho	5959	23	TPs	tp	NNS
cord-006229-7yoilsho	5959	24	may	may	MD
cord-006229-7yoilsho	5959	25	pose	pose	VB
cord-006229-7yoilsho	5959	26	a	a	DT
cord-006229-7yoilsho	5959	27	risk	risk	NN
cord-006229-7yoilsho	5959	28	for	for	IN
cord-006229-7yoilsho	5959	29	human	human	JJ
cord-006229-7yoilsho	5959	30	health	health	NN
cord-006229-7yoilsho	5959	31	.	.	.
cord-006229-7yoilsho	5960	1	Conclusions	conclusion	NNS
cord-006229-7yoilsho	5960	2	:	:	:
cord-006229-7yoilsho	5961	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	5961	2	in	in	IN
cord-006229-7yoilsho	5961	3	-	-	HYPH
cord-006229-7yoilsho	5961	4	silico	silico	NN
cord-006229-7yoilsho	5961	5	analyses	analysis	NNS
cord-006229-7yoilsho	5961	6	of	of	IN
cord-006229-7yoilsho	5961	7	12	12	CD
cord-006229-7yoilsho	5961	8	ACV	ACV	NNP
cord-006229-7yoilsho	5961	9	-	-	HYPH
cord-006229-7yoilsho	5961	10	TPs	TPs	NNP
cord-006229-7yoilsho	5961	11	did	do	VBD
cord-006229-7yoilsho	5961	12	not	not	RB
cord-006229-7yoilsho	5961	13	provide	provide	VB
cord-006229-7yoilsho	5961	14	evidence	evidence	NN
cord-006229-7yoilsho	5961	15	for	for	IN
cord-006229-7yoilsho	5961	16	any	any	DT
cord-006229-7yoilsho	5961	17	adverse	adverse	JJ
cord-006229-7yoilsho	5961	18	health	health	NN
cord-006229-7yoilsho	5961	19	effects	effect	NNS
cord-006229-7yoilsho	5961	20	in	in	IN
cord-006229-7yoilsho	5961	21	the	the	DT
cord-006229-7yoilsho	5961	22	micromolar	micromolar	JJ
cord-006229-7yoilsho	5961	23	concentration	concentration	NN
cord-006229-7yoilsho	5961	24	range	range	NN
cord-006229-7yoilsho	5961	25	.	.	.
cord-006229-7yoilsho	5962	1	Further	further	JJ
cord-006229-7yoilsho	5962	2	studies	study	NNS
cord-006229-7yoilsho	5962	3	are	be	VBP
cord-006229-7yoilsho	5962	4	needed	need	VBN
cord-006229-7yoilsho	5962	5	to	to	TO
cord-006229-7yoilsho	5962	6	clarify	clarify	VB
cord-006229-7yoilsho	5962	7	if	if	IN
cord-006229-7yoilsho	5962	8	the	the	DT
cord-006229-7yoilsho	5962	9	biological	biological	JJ
cord-006229-7yoilsho	5962	10	activity	activity	NN
cord-006229-7yoilsho	5962	11	of	of	IN
cord-006229-7yoilsho	5962	12	some	some	DT
cord-006229-7yoilsho	5962	13	ACV	ACV	NNP
cord-006229-7yoilsho	5962	14	-	-	HYPH
cord-006229-7yoilsho	5962	15	TPs	TPs	NNP
cord-006229-7yoilsho	5962	16	in	in	IN
cord-006229-7yoilsho	5962	17	ecotoxicological	ecotoxicological	JJ
cord-006229-7yoilsho	5962	18	assays	assay	NNS
cord-006229-7yoilsho	5962	19	may	may	MD
cord-006229-7yoilsho	5962	20	eventually	eventually	RB
cord-006229-7yoilsho	5962	21	affect	affect	VB
cord-006229-7yoilsho	5962	22	yet	yet	RB
cord-006229-7yoilsho	5962	23	unidentified	unidentified	JJ
cord-006229-7yoilsho	5962	24	biological	biological	JJ
cord-006229-7yoilsho	5962	25	targets	target	NNS
cord-006229-7yoilsho	5962	26	in	in	IN
cord-006229-7yoilsho	5962	27	the	the	DT
cord-006229-7yoilsho	5962	28	human	human	JJ
cord-006229-7yoilsho	5962	29	body	body	NN
cord-006229-7yoilsho	5962	30	.	.	.
cord-006229-7yoilsho	5963	1	Sulfur	sulfur	NN
cord-006229-7yoilsho	5963	2	mustard	mustard	NN
cord-006229-7yoilsho	5963	3	(	(	-LRB-
cord-006229-7yoilsho	5963	4	SM	SM	NNP
cord-006229-7yoilsho	5963	5	)	)	-RRB-
cord-006229-7yoilsho	5963	6	is	be	VBZ
cord-006229-7yoilsho	5963	7	a	a	DT
cord-006229-7yoilsho	5963	8	chemical	chemical	JJ
cord-006229-7yoilsho	5963	9	warfare	warfare	NN
cord-006229-7yoilsho	5963	10	agent	agent	NN
cord-006229-7yoilsho	5963	11	which	which	WDT
cord-006229-7yoilsho	5963	12	was	be	VBD
cord-006229-7yoilsho	5963	13	first	first	RB
cord-006229-7yoilsho	5963	14	used	use	VBN
cord-006229-7yoilsho	5963	15	in	in	IN
cord-006229-7yoilsho	5963	16	World	World	NNP
cord-006229-7yoilsho	5963	17	War	War	NNP
cord-006229-7yoilsho	5963	18	I	I	NNP
cord-006229-7yoilsho	5963	19	,	,	,
cord-006229-7yoilsho	5963	20	but	but	CC
cord-006229-7yoilsho	5963	21	has	have	VBZ
cord-006229-7yoilsho	5963	22	found	find	VBN
cord-006229-7yoilsho	5963	23	use	use	NN
cord-006229-7yoilsho	5963	24	in	in	IN
cord-006229-7yoilsho	5963	25	several	several	JJ
cord-006229-7yoilsho	5963	26	conflicts	conflict	NNS
cord-006229-7yoilsho	5963	27	afterwards	afterwards	RB
cord-006229-7yoilsho	5963	28	.	.	.
cord-006229-7yoilsho	5964	1	Although	although	IN
cord-006229-7yoilsho	5964	2	SM	SM	NNP
cord-006229-7yoilsho	5964	3	is	be	VBZ
cord-006229-7yoilsho	5964	4	prohibited	prohibit	VBN
cord-006229-7yoilsho	5964	5	by	by	IN
cord-006229-7yoilsho	5964	6	Geneva	Geneva	NNP
cord-006229-7yoilsho	5964	7	Protocol	Protocol	NNP
cord-006229-7yoilsho	5964	8	,	,	,
cord-006229-7yoilsho	5964	9	terroristic	terroristic	JJ
cord-006229-7yoilsho	5964	10	attacks	attack	NNS
cord-006229-7yoilsho	5964	11	can	can	MD
cord-006229-7yoilsho	5964	12	not	not	RB
cord-006229-7yoilsho	5964	13	be	be	VB
cord-006229-7yoilsho	5964	14	ruled	rule	VBN
cord-006229-7yoilsho	5964	15	out	out	RP
cord-006229-7yoilsho	5964	16	.	.	.
cord-006229-7yoilsho	5965	1	Latest	late	JJS
cord-006229-7yoilsho	5965	2	news	news	NN
cord-006229-7yoilsho	5965	3	give	give	VBP
cord-006229-7yoilsho	5965	4	rise	rise	NN
cord-006229-7yoilsho	5965	5	to	to	IN
cord-006229-7yoilsho	5965	6	concern	concern	NN
cord-006229-7yoilsho	5965	7	that	that	WDT
cord-006229-7yoilsho	5965	8	IS	be	VBZ
cord-006229-7yoilsho	5965	9	may	may	MD
cord-006229-7yoilsho	5965	10	be	be	VB
cord-006229-7yoilsho	5965	11	in	in	IN
cord-006229-7yoilsho	5965	12	the	the	DT
cord-006229-7yoilsho	5965	13	possession	possession	NN
cord-006229-7yoilsho	5965	14	of	of	IN
cord-006229-7yoilsho	5965	15	SM	sm	NN
cord-006229-7yoilsho	5965	16	and	and	CC
cord-006229-7yoilsho	5965	17	is	be	VBZ
cord-006229-7yoilsho	5965	18	willing	willing	JJ
cord-006229-7yoilsho	5965	19	to	to	TO
cord-006229-7yoilsho	5965	20	deploy	deploy	VB
cord-006229-7yoilsho	5965	21	it	-PRON-	PRP
cord-006229-7yoilsho	5965	22	.	.	.
cord-006229-7yoilsho	5966	1	Even	even	RB
cord-006229-7yoilsho	5966	2	200	200	CD
cord-006229-7yoilsho	5966	3	years	year	NNS
cord-006229-7yoilsho	5966	4	after	after	IN
cord-006229-7yoilsho	5966	5	the	the	DT
cord-006229-7yoilsho	5966	6	initial	initial	JJ
cord-006229-7yoilsho	5966	7	synthesis	synthesis	NN
cord-006229-7yoilsho	5966	8	of	of	IN
cord-006229-7yoilsho	5966	9	SM	sm	NN
cord-006229-7yoilsho	5966	10	its	-PRON-	PRP$
cord-006229-7yoilsho	5966	11	mode	mode	NN
cord-006229-7yoilsho	5966	12	of	of	IN
cord-006229-7yoilsho	5966	13	action	action	NN
cord-006229-7yoilsho	5966	14	is	be	VBZ
cord-006229-7yoilsho	5966	15	not	not	RB
cord-006229-7yoilsho	5966	16	fully	fully	RB
cord-006229-7yoilsho	5966	17	unraveled	unravel	VBN
cord-006229-7yoilsho	5966	18	.	.	.
cord-006229-7yoilsho	5967	1	Thus	thus	RB
cord-006229-7yoilsho	5967	2	,	,	,
cord-006229-7yoilsho	5967	3	no	no	DT
cord-006229-7yoilsho	5967	4	antidote	antidote	NN
cord-006229-7yoilsho	5967	5	does	do	VBZ
cord-006229-7yoilsho	5967	6	exist	exist	VB
cord-006229-7yoilsho	5967	7	.	.	.
cord-006229-7yoilsho	5968	1	However	however	RB
cord-006229-7yoilsho	5968	2	,	,	,
cord-006229-7yoilsho	5968	3	chemosensing	chemosense	VBG
cord-006229-7yoilsho	5968	4	ion	ion	NN
cord-006229-7yoilsho	5968	5	channels	channel	NNS
cord-006229-7yoilsho	5968	6	have	have	VBP
cord-006229-7yoilsho	5968	7	been	be	VBN
cord-006229-7yoilsho	5968	8	shown	show	VBN
cord-006229-7yoilsho	5968	9	to	to	TO
cord-006229-7yoilsho	5968	10	be	be	VB
cord-006229-7yoilsho	5968	11	activated	activate	VBN
cord-006229-7yoilsho	5968	12	by	by	IN
cord-006229-7yoilsho	5968	13	highly	highly	RB
cord-006229-7yoilsho	5968	14	toxic	toxic	JJ
cord-006229-7yoilsho	5968	15	chemicals	chemical	NNS
cord-006229-7yoilsho	5968	16	and	and	CC
cord-006229-7yoilsho	5968	17	might	may	MD
cord-006229-7yoilsho	5968	18	represent	represent	VB
cord-006229-7yoilsho	5968	19	a	a	DT
cord-006229-7yoilsho	5968	20	specific	specific	JJ
cord-006229-7yoilsho	5968	21	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	5968	22	target	target	NN
cord-006229-7yoilsho	5968	23	.	.	.
cord-006229-7yoilsho	5969	1	Previous	previous	JJ
cord-006229-7yoilsho	5969	2	studies	study	NNS
cord-006229-7yoilsho	5969	3	have	have	VBP
cord-006229-7yoilsho	5969	4	shown	show	VBN
cord-006229-7yoilsho	5969	5	that	that	IN
cord-006229-7yoilsho	5969	6	the	the	DT
cord-006229-7yoilsho	5969	7	SM	sm	NN
cord-006229-7yoilsho	5969	8	-	-	HYPH
cord-006229-7yoilsho	5969	9	surrogate	surrogate	JJ
cord-006229-7yoilsho	5969	10	CEES	CEES	NNP
cord-006229-7yoilsho	5969	11	(	(	-LRB-
cord-006229-7yoilsho	5969	12	mono	mono	JJ
cord-006229-7yoilsho	5969	13	-	-	JJ
cord-006229-7yoilsho	5969	14	functional	functional	JJ
cord-006229-7yoilsho	5969	15	alkylating	alkylating	JJ
cord-006229-7yoilsho	5969	16	agent	agent	NN
cord-006229-7yoilsho	5969	17	)	)	-RRB-
cord-006229-7yoilsho	5969	18	is	be	VBZ
cord-006229-7yoilsho	5969	19	able	able	JJ
cord-006229-7yoilsho	5969	20	to	to	TO
cord-006229-7yoilsho	5969	21	activate	activate	VB
cord-006229-7yoilsho	5969	22	Transient	transient	JJ
cord-006229-7yoilsho	5969	23	Receptor	Receptor	NNP
cord-006229-7yoilsho	5969	24	Potential	Potential	NNP
cord-006229-7yoilsho	5969	25	Ankyrin	Ankyrin	NNP
cord-006229-7yoilsho	5969	26	1	1	CD
cord-006229-7yoilsho	5970	1	(	(	-LRB-
cord-006229-7yoilsho	5970	2	TRPA1	trpa1	NN
cord-006229-7yoilsho	5970	3	)	)	-RRB-
cord-006229-7yoilsho	5970	4	channels	channel	NNS
cord-006229-7yoilsho	5970	5	that	that	WDT
cord-006229-7yoilsho	5970	6	are	be	VBP
cord-006229-7yoilsho	5970	7	known	know	VBN
cord-006229-7yoilsho	5970	8	to	to	TO
cord-006229-7yoilsho	5970	9	affect	affect	VB
cord-006229-7yoilsho	5970	10	MAPK	MAPK	NNP
cord-006229-7yoilsho	5970	11	cell	cell	NN
cord-006229-7yoilsho	5970	12	signaling	signaling	NN
cord-006229-7yoilsho	5970	13	.	.	.
cord-006229-7yoilsho	5971	1	MAPK	MAPK	NNP
cord-006229-7yoilsho	5971	2	-	-	HYPH
cord-006229-7yoilsho	5971	3	pathways	pathway	NNS
cord-006229-7yoilsho	5971	4	,	,	,
cord-006229-7yoilsho	5971	5	especially	especially	RB
cord-006229-7yoilsho	5971	6	pERK1/2	pERK1/2	NNP
cord-006229-7yoilsho	5971	7	,	,	,
cord-006229-7yoilsho	5971	8	are	be	VBP
cord-006229-7yoilsho	5971	9	known	know	VBN
cord-006229-7yoilsho	5971	10	to	to	TO
cord-006229-7yoilsho	5971	11	increase	increase	VB
cord-006229-7yoilsho	5971	12	protein	protein	NN
cord-006229-7yoilsho	5971	13	biosynthesis	biosynthesis	NN
cord-006229-7yoilsho	5971	14	through	through	IN
cord-006229-7yoilsho	5971	15	activation	activation	NN
cord-006229-7yoilsho	5971	16	of	of	IN
cord-006229-7yoilsho	5971	17	transcription	transcription	NN
cord-006229-7yoilsho	5971	18	factors	factor	NNS
cord-006229-7yoilsho	5971	19	binding	bind	VBG
cord-006229-7yoilsho	5971	20	to	to	IN
cord-006229-7yoilsho	5971	21	the	the	DT
cord-006229-7yoilsho	5971	22	serum	serum	NN
cord-006229-7yoilsho	5971	23	response	response	NN
cord-006229-7yoilsho	5971	24	element	element	NN
cord-006229-7yoilsho	5971	25	(	(	-LRB-
cord-006229-7yoilsho	5971	26	SRE	SRE	NNP
cord-006229-7yoilsho	5971	27	)	)	-RRB-
cord-006229-7yoilsho	5971	28	.	.	.
cord-006229-7yoilsho	5972	1	It	-PRON-	PRP
cord-006229-7yoilsho	5972	2	is	be	VBZ
cord-006229-7yoilsho	5972	3	unknown	unknown	JJ
cord-006229-7yoilsho	5972	4	whether	whether	IN
cord-006229-7yoilsho	5972	5	alkylating	alkylating	JJ
cord-006229-7yoilsho	5972	6	agents	agent	NNS
cord-006229-7yoilsho	5972	7	have	have	VBP
cord-006229-7yoilsho	5972	8	also	also	RB
cord-006229-7yoilsho	5972	9	impact	impact	NN
cord-006229-7yoilsho	5972	10	on	on	IN
cord-006229-7yoilsho	5972	11	MAPK	MAPK	NNP
cord-006229-7yoilsho	5972	12	signaling	signal	VBG
cord-006229-7yoilsho	5972	13	mediated	mediate	VBN
cord-006229-7yoilsho	5972	14	through	through	IN
cord-006229-7yoilsho	5972	15	TRPA1	trpa1	DT
cord-006229-7yoilsho	5972	16	activation	activation	NN
cord-006229-7yoilsho	5972	17	.	.	.
cord-006229-7yoilsho	5973	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	5973	2	results	result	NNS
cord-006229-7yoilsho	5973	3	demonstrate	demonstrate	VBP
cord-006229-7yoilsho	5973	4	that	that	IN
cord-006229-7yoilsho	5973	5	AITC	AITC	NNP
cord-006229-7yoilsho	5973	6	resulted	result	VBD
cord-006229-7yoilsho	5973	7	in	in	IN
cord-006229-7yoilsho	5973	8	phosphorylation	phosphorylation	NN
cord-006229-7yoilsho	5973	9	of	of	IN
cord-006229-7yoilsho	5973	10	the	the	DT
cord-006229-7yoilsho	5973	11	MAPK	MAPK	NNP
cord-006229-7yoilsho	5973	12	pERK1/2	perk1/2	NN
cord-006229-7yoilsho	5973	13	and	and	CC
cord-006229-7yoilsho	5973	14	increased	increase	VBN
cord-006229-7yoilsho	5973	15	protein	protein	NN
cord-006229-7yoilsho	5973	16	biosynthesis	biosynthesis	NN
cord-006229-7yoilsho	5973	17	of	of	IN
cord-006229-7yoilsho	5973	18	SRE	SRE	NNP
cord-006229-7yoilsho	5973	19	-	-	HYPH
cord-006229-7yoilsho	5973	20	regulated	regulate	VBN
cord-006229-7yoilsho	5973	21	genes	gene	NNS
cord-006229-7yoilsho	5973	22	in	in	IN
cord-006229-7yoilsho	5973	23	HEK293	HEK293	NNP
cord-006229-7yoilsho	5973	24	cells	cell	NNS
cord-006229-7yoilsho	5973	25	overexpressing	overexpresse	VBG
cord-006229-7yoilsho	5973	26	hTRPA1	htrpa1	NN
cord-006229-7yoilsho	5973	27	.	.	.
cord-006229-7yoilsho	5974	1	CEES	CEES	NNP
cord-006229-7yoilsho	5974	2	increased	increase	VBD
cord-006229-7yoilsho	5974	3	pERK1/2	perk1/2	NN
cord-006229-7yoilsho	5974	4	levels	level	NNS
cord-006229-7yoilsho	5974	5	already	already	RB
cord-006229-7yoilsho	5974	6	after	after	IN
cord-006229-7yoilsho	5974	7	2.5	2.5	CD
cord-006229-7yoilsho	5974	8	min	min	NN
cord-006229-7yoilsho	5974	9	which	which	WDT
cord-006229-7yoilsho	5974	10	could	could	MD
cord-006229-7yoilsho	5974	11	be	be	VB
cord-006229-7yoilsho	5974	12	prevented	prevent	VBN
cord-006229-7yoilsho	5974	13	by	by	IN
cord-006229-7yoilsho	5974	14	the	the	DT
cord-006229-7yoilsho	5974	15	TRPA1	trpa1	NN
cord-006229-7yoilsho	5974	16	blocker	blocker	NN
cord-006229-7yoilsho	5974	17	AP18	AP18	NNP
cord-006229-7yoilsho	5974	18	.	.	.
cord-006229-7yoilsho	5975	1	Activation	activation	NN
cord-006229-7yoilsho	5975	2	of	of	IN
cord-006229-7yoilsho	5975	3	target	target	NN
cord-006229-7yoilsho	5975	4	genes	gene	NNS
cord-006229-7yoilsho	5975	5	through	through	IN
cord-006229-7yoilsho	5975	6	pERK1/2	perk1/2	NN
cord-006229-7yoilsho	5975	7	signaling	signaling	NN
cord-006229-7yoilsho	5975	8	was	be	VBD
cord-006229-7yoilsho	5975	9	also	also	RB
cord-006229-7yoilsho	5975	10	evident	evident	JJ
cord-006229-7yoilsho	5975	11	,	,	,
cord-006229-7yoilsho	5975	12	but	but	CC
cord-006229-7yoilsho	5975	13	less	less	RBR
cord-006229-7yoilsho	5975	14	pronounced	pronounced	JJ
cord-006229-7yoilsho	5975	15	compared	compare	VBN
cord-006229-7yoilsho	5975	16	to	to	IN
cord-006229-7yoilsho	5975	17	AITC	AITC	NNP
cord-006229-7yoilsho	5975	18	.	.	.
cord-006229-7yoilsho	5976	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	5976	2	results	result	NNS
cord-006229-7yoilsho	5976	3	demonstrate	demonstrate	VBP
cord-006229-7yoilsho	5976	4	that	that	IN
cord-006229-7yoilsho	5976	5	alkylating	alkylating	JJ
cord-006229-7yoilsho	5976	6	agents	agent	NNS
cord-006229-7yoilsho	5976	7	have	have	VBP
cord-006229-7yoilsho	5976	8	impact	impact	NN
cord-006229-7yoilsho	5976	9	on	on	IN
cord-006229-7yoilsho	5976	10	cell	cell	NN
cord-006229-7yoilsho	5976	11	signaling	signal	VBG
cord-006229-7yoilsho	5976	12	through	through	IN
cord-006229-7yoilsho	5976	13	TRPA1	trpa1	DT
cord-006229-7yoilsho	5976	14	channel	channel	NN
cord-006229-7yoilsho	5976	15	activation	activation	NN
cord-006229-7yoilsho	5976	16	.	.	.
cord-006229-7yoilsho	5977	1	Thus	thus	RB
cord-006229-7yoilsho	5977	2	,	,	,
cord-006229-7yoilsho	5977	3	TRPA1	trpa1	XX
cord-006229-7yoilsho	5977	4	might	may	MD
cord-006229-7yoilsho	5977	5	represent	represent	VB
cord-006229-7yoilsho	5977	6	a	a	DT
cord-006229-7yoilsho	5977	7	promising	promising	JJ
cord-006229-7yoilsho	5977	8	target	target	NN
cord-006229-7yoilsho	5977	9	for	for	IN
cord-006229-7yoilsho	5977	10	counteracting	counteract	VBG
cord-006229-7yoilsho	5977	11	SM	sm	NN
cord-006229-7yoilsho	5977	12	toxicity	toxicity	NN
cord-006229-7yoilsho	5977	13	.	.	.
cord-006229-7yoilsho	5978	1	Sulfur	sulfur	NN
cord-006229-7yoilsho	5978	2	mustard	mustard	NN
cord-006229-7yoilsho	5978	3	(	(	-LRB-
cord-006229-7yoilsho	5978	4	SM	SM	NNP
cord-006229-7yoilsho	5978	5	)	)	-RRB-
cord-006229-7yoilsho	5978	6	is	be	VBZ
cord-006229-7yoilsho	5978	7	a	a	DT
cord-006229-7yoilsho	5978	8	chemical	chemical	JJ
cord-006229-7yoilsho	5978	9	warfare	warfare	NN
cord-006229-7yoilsho	5978	10	agent	agent	NN
cord-006229-7yoilsho	5978	11	that	that	WDT
cord-006229-7yoilsho	5978	12	provokes	provoke	VBZ
cord-006229-7yoilsho	5978	13	severe	severe	JJ
cord-006229-7yoilsho	5978	14	inflammation	inflammation	NN
cord-006229-7yoilsho	5978	15	and	and	CC
cord-006229-7yoilsho	5978	16	blistering	blistering	NN
cord-006229-7yoilsho	5978	17	upon	upon	IN
cord-006229-7yoilsho	5978	18	exposure	exposure	NN
cord-006229-7yoilsho	5978	19	to	to	IN
cord-006229-7yoilsho	5978	20	the	the	DT
cord-006229-7yoilsho	5978	21	skin	skin	NN
cord-006229-7yoilsho	5978	22	accompanied	accompany	VBN
cord-006229-7yoilsho	5978	23	by	by	IN
cord-006229-7yoilsho	5978	24	disturbed	disturbed	JJ
cord-006229-7yoilsho	5978	25	wound	wound	NN
cord-006229-7yoilsho	5978	26	healing	healing	NN
cord-006229-7yoilsho	5978	27	.	.	.
cord-006229-7yoilsho	5979	1	The	the	DT
cord-006229-7yoilsho	5979	2	potential	potential	JJ
cord-006229-7yoilsho	5979	3	use	use	NN
cord-006229-7yoilsho	5979	4	of	of	IN
cord-006229-7yoilsho	5979	5	SM	sm	NN
cord-006229-7yoilsho	5979	6	in	in	IN
cord-006229-7yoilsho	5979	7	terroristic	terroristic	JJ
cord-006229-7yoilsho	5979	8	assaults	assault	NNS
cord-006229-7yoilsho	5979	9	amplified	amplify	VBD
cord-006229-7yoilsho	5979	10	the	the	DT
cord-006229-7yoilsho	5979	11	interest	interest	NN
cord-006229-7yoilsho	5979	12	in	in	IN
cord-006229-7yoilsho	5979	13	understanding	understand	VBG
cord-006229-7yoilsho	5979	14	the	the	DT
cord-006229-7yoilsho	5979	15	underlying	underlie	VBG
cord-006229-7yoilsho	5979	16	cellular	cellular	JJ
cord-006229-7yoilsho	5979	17	and	and	CC
cord-006229-7yoilsho	5979	18	molecular	molecular	JJ
cord-006229-7yoilsho	5979	19	pathomechanisms	pathomechanism	NNS
cord-006229-7yoilsho	5979	20	in	in	IN
cord-006229-7yoilsho	5979	21	order	order	NN
cord-006229-7yoilsho	5979	22	to	to	TO
cord-006229-7yoilsho	5979	23	improve	improve	VB
cord-006229-7yoilsho	5979	24	therapeutical	therapeutical	JJ
cord-006229-7yoilsho	5979	25	intervention	intervention	NN
cord-006229-7yoilsho	5979	26	.	.	.
cord-006229-7yoilsho	5980	1	Autophagy	Autophagy	NNP
cord-006229-7yoilsho	5980	2	is	be	VBZ
cord-006229-7yoilsho	5980	3	a	a	DT
cord-006229-7yoilsho	5980	4	highly	highly	RB
cord-006229-7yoilsho	5980	5	conserved	conserved	JJ
cord-006229-7yoilsho	5980	6	catabolic	catabolic	JJ
cord-006229-7yoilsho	5980	7	pathway	pathway	NN
cord-006229-7yoilsho	5980	8	in	in	IN
cord-006229-7yoilsho	5980	9	eukaryotes	eukaryote	NNS
cord-006229-7yoilsho	5980	10	that	that	WDT
cord-006229-7yoilsho	5980	11	ensures	ensure	VBZ
cord-006229-7yoilsho	5980	12	the	the	DT
cord-006229-7yoilsho	5980	13	degradation	degradation	NN
cord-006229-7yoilsho	5980	14	and	and	CC
cord-006229-7yoilsho	5980	15	recycling	recycling	NN
cord-006229-7yoilsho	5980	16	of	of	IN
cord-006229-7yoilsho	5980	17	cellular	cellular	JJ
cord-006229-7yoilsho	5980	18	components	component	NNS
cord-006229-7yoilsho	5980	19	through	through	IN
cord-006229-7yoilsho	5980	20	the	the	DT
cord-006229-7yoilsho	5980	21	lysosomal	lysosomal	JJ
cord-006229-7yoilsho	5980	22	machinery	machinery	NN
cord-006229-7yoilsho	5980	23	.	.	.
cord-006229-7yoilsho	5981	1	Autophagy	Autophagy	NNP
cord-006229-7yoilsho	5981	2	is	be	VBZ
cord-006229-7yoilsho	5981	3	important	important	JJ
cord-006229-7yoilsho	5981	4	for	for	IN
cord-006229-7yoilsho	5981	5	cell	cell	NN
cord-006229-7yoilsho	5981	6	survival	survival	NN
cord-006229-7yoilsho	5981	7	in	in	IN
cord-006229-7yoilsho	5981	8	physiological	physiological	JJ
cord-006229-7yoilsho	5981	9	and	and	CC
cord-006229-7yoilsho	5981	10	pathological	pathological	JJ
cord-006229-7yoilsho	5981	11	stress	stress	NN
cord-006229-7yoilsho	5981	12	situations	situation	NNS
cord-006229-7yoilsho	5981	13	.	.	.
cord-006229-7yoilsho	5982	1	Emerging	emerge	VBG
cord-006229-7yoilsho	5982	2	knowledge	knowledge	NN
cord-006229-7yoilsho	5982	3	indicates	indicate	VBZ
cord-006229-7yoilsho	5982	4	that	that	IN
cord-006229-7yoilsho	5982	5	imbalanced	imbalanced	JJ
cord-006229-7yoilsho	5982	6	regulation	regulation	NN
cord-006229-7yoilsho	5982	7	of	of	IN
cord-006229-7yoilsho	5982	8	autophagy	autophagy	NN
cord-006229-7yoilsho	5982	9	disturbs	disturb	VBZ
cord-006229-7yoilsho	5982	10	basal	basal	JJ
cord-006229-7yoilsho	5982	11	cell	cell	NN
cord-006229-7yoilsho	5982	12	functions	function	NNS
cord-006229-7yoilsho	5982	13	including	include	VBG
cord-006229-7yoilsho	5982	14	proliferation	proliferation	NN
cord-006229-7yoilsho	5982	15	,	,	,
cord-006229-7yoilsho	5982	16	differentiation	differentiation	NN
cord-006229-7yoilsho	5982	17	and	and	CC
cord-006229-7yoilsho	5982	18	migration	migration	NN
cord-006229-7yoilsho	5982	19	,	,	,
cord-006229-7yoilsho	5982	20	thus	thus	RB
cord-006229-7yoilsho	5982	21	contributing	contribute	VBG
cord-006229-7yoilsho	5982	22	to	to	IN
cord-006229-7yoilsho	5982	23	the	the	DT
cord-006229-7yoilsho	5982	24	pathophysiology	pathophysiology	NN
cord-006229-7yoilsho	5982	25	of	of	IN
cord-006229-7yoilsho	5982	26	various	various	JJ
cord-006229-7yoilsho	5982	27	diseases	disease	NNS
cord-006229-7yoilsho	5982	28	.	.	.
cord-006229-7yoilsho	5983	1	After	after	IN
cord-006229-7yoilsho	5983	2	penetration	penetration	NN
cord-006229-7yoilsho	5983	3	into	into	IN
cord-006229-7yoilsho	5983	4	skin	skin	NN
cord-006229-7yoilsho	5983	5	cells	cell	NNS
cord-006229-7yoilsho	5983	6	,	,	,
cord-006229-7yoilsho	5983	7	SM	sm	NN
cord-006229-7yoilsho	5983	8	alkylates	alkylate	NNS
cord-006229-7yoilsho	5983	9	and	and	CC
cord-006229-7yoilsho	5983	10	thereby	thereby	RB
cord-006229-7yoilsho	5983	11	modifies	modify	VBZ
cord-006229-7yoilsho	5983	12	nucleic	nucleic	JJ
cord-006229-7yoilsho	5983	13	acids	acid	NNS
cord-006229-7yoilsho	5983	14	and	and	CC
cord-006229-7yoilsho	5983	15	proteins	protein	NNS
cord-006229-7yoilsho	5983	16	thus	thus	RB
cord-006229-7yoilsho	5983	17	forming	form	VBG
cord-006229-7yoilsho	5983	18	aggregates	aggregate	NNS
cord-006229-7yoilsho	5983	19	of	of	IN
cord-006229-7yoilsho	5983	20	dysfunctional	dysfunctional	JJ
cord-006229-7yoilsho	5983	21	proteins	protein	NNS
cord-006229-7yoilsho	5983	22	destined	destine	VBN
cord-006229-7yoilsho	5983	23	for	for	IN
cord-006229-7yoilsho	5983	24	autophagic	autophagic	NN
cord-006229-7yoilsho	5983	25	disposal	disposal	NN
cord-006229-7yoilsho	5983	26	.	.	.
cord-006229-7yoilsho	5984	1	In	in	IN
cord-006229-7yoilsho	5984	2	our	-PRON-	PRP$
cord-006229-7yoilsho	5984	3	studies	study	NNS
cord-006229-7yoilsho	5984	4	,	,	,
cord-006229-7yoilsho	5984	5	we	-PRON-	PRP
cord-006229-7yoilsho	5984	6	analyzed	analyze	VBD
cord-006229-7yoilsho	5984	7	the	the	DT
cord-006229-7yoilsho	5984	8	influence	influence	NN
cord-006229-7yoilsho	5984	9	of	of	IN
cord-006229-7yoilsho	5984	10	SM	SM	NNP
cord-006229-7yoilsho	5984	11	on	on	IN
cord-006229-7yoilsho	5984	12	protein	protein	NN
cord-006229-7yoilsho	5984	13	expression	expression	NN
cord-006229-7yoilsho	5984	14	(	(	-LRB-
cord-006229-7yoilsho	5984	15	Western	western	JJ
cord-006229-7yoilsho	5984	16	blotting	blotting	NN
cord-006229-7yoilsho	5984	17	)	)	-RRB-
cord-006229-7yoilsho	5984	18	of	of	IN
cord-006229-7yoilsho	5984	19	autophagy	autophagy	NN
cord-006229-7yoilsho	5984	20	-	-	HYPH
cord-006229-7yoilsho	5984	21	related	relate	VBN
cord-006229-7yoilsho	5984	22	(	(	-LRB-
cord-006229-7yoilsho	5984	23	ATG	ATG	NNP
cord-006229-7yoilsho	5984	24	)	)	-RRB-
cord-006229-7yoilsho	5984	25	genes	gene	NNS
cord-006229-7yoilsho	5984	26	as	as	RB
cord-006229-7yoilsho	5984	27	well	well	RB
cord-006229-7yoilsho	5984	28	as	as	IN
cord-006229-7yoilsho	5984	29	proliferation	proliferation	NN
cord-006229-7yoilsho	5984	30	(	(	-LRB-
cord-006229-7yoilsho	5984	31	WST-1	WST-1	NNP
cord-006229-7yoilsho	5984	32	)	)	-RRB-
cord-006229-7yoilsho	5984	33	of	of	IN
cord-006229-7yoilsho	5984	34	primary	primary	JJ
cord-006229-7yoilsho	5984	35	normal	normal	JJ
cord-006229-7yoilsho	5984	36	human	human	JJ
cord-006229-7yoilsho	5984	37	keratinocytes	keratinocyte	NNS
cord-006229-7yoilsho	5984	38	(	(	-LRB-
cord-006229-7yoilsho	5984	39	NHEK	NHEK	NNP
cord-006229-7yoilsho	5984	40	)	)	-RRB-
cord-006229-7yoilsho	5984	41	and	and	CC
cord-006229-7yoilsho	5984	42	primary	primary	JJ
cord-006229-7yoilsho	5984	43	normal	normal	JJ
cord-006229-7yoilsho	5984	44	human	human	JJ
cord-006229-7yoilsho	5984	45	dermal	dermal	JJ
cord-006229-7yoilsho	5984	46	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	5984	47	(	(	-LRB-
cord-006229-7yoilsho	5984	48	NHDF	NHDF	NNP
cord-006229-7yoilsho	5984	49	)	)	-RRB-
cord-006229-7yoilsho	5984	50	.	.	.
cord-006229-7yoilsho	5985	1	Preliminary	preliminary	JJ
cord-006229-7yoilsho	5985	2	results	result	NNS
cord-006229-7yoilsho	5985	3	demonstrate	demonstrate	VBP
cord-006229-7yoilsho	5985	4	that	that	IN
cord-006229-7yoilsho	5985	5	SM	SM	NNP
cord-006229-7yoilsho	5985	6	strongly	strongly	RB
cord-006229-7yoilsho	5985	7	dysregulates	dysregulate	VBZ
cord-006229-7yoilsho	5985	8	the	the	DT
cord-006229-7yoilsho	5985	9	biosynthesis	biosynthesis	NN
cord-006229-7yoilsho	5985	10	of	of	IN
cord-006229-7yoilsho	5985	11	ATG	ATG	NNP
cord-006229-7yoilsho	5985	12	proteins	protein	NNS
cord-006229-7yoilsho	5985	13	that	that	WDT
cord-006229-7yoilsho	5985	14	may	may	MD
cord-006229-7yoilsho	5985	15	contribute	contribute	VB
cord-006229-7yoilsho	5985	16	to	to	IN
cord-006229-7yoilsho	5985	17	the	the	DT
cord-006229-7yoilsho	5985	18	diminished	diminished	JJ
cord-006229-7yoilsho	5985	19	cell	cell	NN
cord-006229-7yoilsho	5985	20	migration	migration	NN
cord-006229-7yoilsho	5985	21	and	and	CC
cord-006229-7yoilsho	5985	22	proliferation	proliferation	NN
cord-006229-7yoilsho	5985	23	under	under	IN
cord-006229-7yoilsho	5985	24	these	these	DT
cord-006229-7yoilsho	5985	25	conditions	condition	NNS
cord-006229-7yoilsho	5985	26	.	.	.
cord-006229-7yoilsho	5986	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	5986	2	findings	finding	NNS
cord-006229-7yoilsho	5986	3	suggest	suggest	VBP
cord-006229-7yoilsho	5986	4	that	that	IN
cord-006229-7yoilsho	5986	5	SM	sm	NN
cord-006229-7yoilsho	5986	6	affects	affect	VBZ
cord-006229-7yoilsho	5986	7	autophagy	autophagy	NN
cord-006229-7yoilsho	5986	8	in	in	IN
cord-006229-7yoilsho	5986	9	correlation	correlation	NN
cord-006229-7yoilsho	5986	10	with	with	IN
cord-006229-7yoilsho	5986	11	an	an	DT
cord-006229-7yoilsho	5986	12	impairment	impairment	NN
cord-006229-7yoilsho	5986	13	of	of	IN
cord-006229-7yoilsho	5986	14	physiological	physiological	JJ
cord-006229-7yoilsho	5986	15	functions	function	NNS
cord-006229-7yoilsho	5986	16	in	in	IN
cord-006229-7yoilsho	5986	17	keratinocytes	keratinocyte	NNS
cord-006229-7yoilsho	5986	18	and	and	CC
cord-006229-7yoilsho	5986	19	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	5986	20	that	that	WDT
cord-006229-7yoilsho	5986	21	are	be	VBP
cord-006229-7yoilsho	5986	22	essentially	essentially	RB
cord-006229-7yoilsho	5986	23	required	require	VBN
cord-006229-7yoilsho	5986	24	for	for	IN
cord-006229-7yoilsho	5986	25	normal	normal	JJ
cord-006229-7yoilsho	5986	26	tissue	tissue	NN
cord-006229-7yoilsho	5986	27	regeneration	regeneration	NN
cord-006229-7yoilsho	5986	28	.	.	.
cord-006229-7yoilsho	5987	1	Thus	thus	RB
cord-006229-7yoilsho	5987	2	,	,	,
cord-006229-7yoilsho	5987	3	application	application	NN
cord-006229-7yoilsho	5987	4	of	of	IN
cord-006229-7yoilsho	5987	5	pharmacological	pharmacological	JJ
cord-006229-7yoilsho	5987	6	modulators	modulator	NNS
cord-006229-7yoilsho	5987	7	of	of	IN
cord-006229-7yoilsho	5987	8	autophagy	autophagy	NN
cord-006229-7yoilsho	5987	9	might	may	MD
cord-006229-7yoilsho	5987	10	be	be	VB
cord-006229-7yoilsho	5987	11	useful	useful	JJ
cord-006229-7yoilsho	5987	12	in	in	IN
cord-006229-7yoilsho	5987	13	the	the	DT
cord-006229-7yoilsho	5987	14	treatment	treatment	NN
cord-006229-7yoilsho	5987	15	of	of	IN
cord-006229-7yoilsho	5987	16	the	the	DT
cord-006229-7yoilsho	5987	17	delayed	delay	VBN
cord-006229-7yoilsho	5987	18	wound	wound	NN
cord-006229-7yoilsho	5987	19	healing	healing	NN
cord-006229-7yoilsho	5987	20	in	in	IN
cord-006229-7yoilsho	5987	21	skin	skin	NN
cord-006229-7yoilsho	5987	22	upon	upon	IN
cord-006229-7yoilsho	5987	23	exposure	exposure	NN
cord-006229-7yoilsho	5987	24	to	to	IN
cord-006229-7yoilsho	5987	25	SM	sm	NN
cord-006229-7yoilsho	5987	26	.	.	.
cord-006229-7yoilsho	5988	1	Exposure	exposure	NN
cord-006229-7yoilsho	5988	2	of	of	IN
cord-006229-7yoilsho	5988	3	the	the	DT
cord-006229-7yoilsho	5988	4	respiratory	respiratory	JJ
cord-006229-7yoilsho	5988	5	tract	tract	NN
cord-006229-7yoilsho	5988	6	to	to	IN
cord-006229-7yoilsho	5988	7	airborne	airborne	JJ
cord-006229-7yoilsho	5988	8	particles	particle	NNS
cord-006229-7yoilsho	5988	9	is	be	VBZ
cord-006229-7yoilsho	5988	10	a	a	DT
cord-006229-7yoilsho	5988	11	major	major	JJ
cord-006229-7yoilsho	5988	12	risk	risk	NN
cord-006229-7yoilsho	5988	13	to	to	IN
cord-006229-7yoilsho	5988	14	human	human	JJ
cord-006229-7yoilsho	5988	15	health	health	NN
cord-006229-7yoilsho	5988	16	.	.	.
cord-006229-7yoilsho	5989	1	Due	due	IN
cord-006229-7yoilsho	5989	2	to	to	IN
cord-006229-7yoilsho	5989	3	the	the	DT
cord-006229-7yoilsho	5989	4	ubiquitous	ubiquitous	JJ
cord-006229-7yoilsho	5989	5	application	application	NN
cord-006229-7yoilsho	5989	6	of	of	IN
cord-006229-7yoilsho	5989	7	these	these	DT
cord-006229-7yoilsho	5989	8	particles	particle	NNS
cord-006229-7yoilsho	5989	9	in	in	IN
cord-006229-7yoilsho	5989	10	the	the	DT
cord-006229-7yoilsho	5989	11	field	field	NN
cord-006229-7yoilsho	5989	12	of	of	IN
cord-006229-7yoilsho	5989	13	pharmacy	pharmacy	NN
cord-006229-7yoilsho	5989	14	,	,	,
cord-006229-7yoilsho	5989	15	industry	industry	NN
cord-006229-7yoilsho	5989	16	and	and	CC
cord-006229-7yoilsho	5989	17	in	in	IN
cord-006229-7yoilsho	5989	18	daily	daily	JJ
cord-006229-7yoilsho	5989	19	life	life	NN
cord-006229-7yoilsho	5989	20	,	,	,
cord-006229-7yoilsho	5989	21	there	there	EX
cord-006229-7yoilsho	5989	22	is	be	VBZ
cord-006229-7yoilsho	5989	23	a	a	DT
cord-006229-7yoilsho	5989	24	strong	strong	JJ
cord-006229-7yoilsho	5989	25	necessity	necessity	NN
cord-006229-7yoilsho	5989	26	to	to	TO
cord-006229-7yoilsho	5989	27	investigate	investigate	VB
cord-006229-7yoilsho	5989	28	the	the	DT
cord-006229-7yoilsho	5989	29	toxic	toxic	JJ
cord-006229-7yoilsho	5989	30	properties	property	NNS
cord-006229-7yoilsho	5989	31	and	and	CC
cord-006229-7yoilsho	5989	32	the	the	DT
cord-006229-7yoilsho	5989	33	underlying	underlie	VBG
cord-006229-7yoilsho	5989	34	pathomechanisms	pathomechanism	NNS
cord-006229-7yoilsho	5989	35	of	of	IN
cord-006229-7yoilsho	5989	36	these	these	DT
cord-006229-7yoilsho	5989	37	inhalable	inhalable	JJ
cord-006229-7yoilsho	5989	38	substances	substance	NNS
cord-006229-7yoilsho	5989	39	.	.	.
cord-006229-7yoilsho	5990	1	In	in	IN
cord-006229-7yoilsho	5990	2	addition	addition	NN
cord-006229-7yoilsho	5990	3	,	,	,
cord-006229-7yoilsho	5990	4	the	the	DT
cord-006229-7yoilsho	5990	5	EU	EU	NNP
cord-006229-7yoilsho	5990	6	Chemicals	Chemicals	NNPS
cord-006229-7yoilsho	5990	7	Regulation	regulation	NN
cord-006229-7yoilsho	5990	8	requires	require	VBZ
cord-006229-7yoilsho	5990	9	not	not	RB
cord-006229-7yoilsho	5990	10	only	only	RB
cord-006229-7yoilsho	5990	11	that	that	IN
cord-006229-7yoilsho	5990	12	all	all	DT
cord-006229-7yoilsho	5990	13	substances	substance	NNS
cord-006229-7yoilsho	5990	14	placed	place	VBN
cord-006229-7yoilsho	5990	15	on	on	IN
cord-006229-7yoilsho	5990	16	the	the	DT
cord-006229-7yoilsho	5990	17	market	market	NN
cord-006229-7yoilsho	5990	18	have	have	VBP
cord-006229-7yoilsho	5990	19	to	to	TO
cord-006229-7yoilsho	5990	20	undergo	undergo	VB
cord-006229-7yoilsho	5990	21	a	a	DT
cord-006229-7yoilsho	5990	22	toxicological	toxicological	JJ
cord-006229-7yoilsho	5990	23	characterization	characterization	NN
cord-006229-7yoilsho	5990	24	,	,	,
cord-006229-7yoilsho	5990	25	including	include	VBG
cord-006229-7yoilsho	5990	26	the	the	DT
cord-006229-7yoilsho	5990	27	identification	identification	NN
cord-006229-7yoilsho	5990	28	of	of	IN
cord-006229-7yoilsho	5990	29	potential	potential	JJ
cord-006229-7yoilsho	5990	30	toxic	toxic	JJ
cord-006229-7yoilsho	5990	31	inhalation	inhalation	NN
cord-006229-7yoilsho	5990	32	hazards	hazard	NNS
cord-006229-7yoilsho	5990	33	(	(	-LRB-
cord-006229-7yoilsho	5990	34	REACH	reach	VB
cord-006229-7yoilsho	5990	35	)	)	-RRB-
cord-006229-7yoilsho	5990	36	,	,	,
cord-006229-7yoilsho	5990	37	but	but	CC
cord-006229-7yoilsho	5990	38	also	also	RB
cord-006229-7yoilsho	5990	39	that	that	IN
cord-006229-7yoilsho	5990	40	animal	animal	NN
cord-006229-7yoilsho	5990	41	testing	testing	NN
cord-006229-7yoilsho	5990	42	shall	shall	MD
cord-006229-7yoilsho	5990	43	be	be	VB
cord-006229-7yoilsho	5990	44	undertaken	undertake	VBN
cord-006229-7yoilsho	5990	45	only	only	RB
cord-006229-7yoilsho	5990	46	as	as	IN
cord-006229-7yoilsho	5990	47	a	a	DT
cord-006229-7yoilsho	5990	48	last	last	JJ
cord-006229-7yoilsho	5990	49	resort	resort	NN
cord-006229-7yoilsho	5990	50	(	(	-LRB-
cord-006229-7yoilsho	5990	51	"	"	``
cord-006229-7yoilsho	5990	52	3Rs	3rs	JJ
cord-006229-7yoilsho	5990	53	"	"	''
cord-006229-7yoilsho	5990	54	principle	principle	NN
cord-006229-7yoilsho	5990	55	)	)	-RRB-
cord-006229-7yoilsho	5990	56	and	and	CC
cord-006229-7yoilsho	5990	57	the	the	DT
cord-006229-7yoilsho	5990	58	promotion	promotion	NN
cord-006229-7yoilsho	5990	59	of	of	IN
cord-006229-7yoilsho	5990	60	the	the	DT
cord-006229-7yoilsho	5990	61	development	development	NN
cord-006229-7yoilsho	5990	62	of	of	IN
cord-006229-7yoilsho	5990	63	alternative	alternative	JJ
cord-006229-7yoilsho	5990	64	methods	method	NNS
cord-006229-7yoilsho	5990	65	.	.	.
cord-006229-7yoilsho	5991	1	Thus	thus	RB
cord-006229-7yoilsho	5991	2	,	,	,
cord-006229-7yoilsho	5991	3	the	the	DT
cord-006229-7yoilsho	5991	4	development	development	NN
cord-006229-7yoilsho	5991	5	,	,	,
cord-006229-7yoilsho	5991	6	establishment	establishment	NN
cord-006229-7yoilsho	5991	7	and	and	CC
cord-006229-7yoilsho	5991	8	validation	validation	NN
cord-006229-7yoilsho	5991	9	of	of	IN
cord-006229-7yoilsho	5991	10	alternative	alternative	NN
cord-006229-7yoilsho	5991	11	in	in	IN
cord-006229-7yoilsho	5991	12	vitrobased	vitrobased	JJ
cord-006229-7yoilsho	5991	13	test	test	NN
cord-006229-7yoilsho	5991	14	systems	system	NNS
cord-006229-7yoilsho	5991	15	for	for	IN
cord-006229-7yoilsho	5991	16	the	the	DT
cord-006229-7yoilsho	5991	17	assessment	assessment	NN
cord-006229-7yoilsho	5991	18	of	of	IN
cord-006229-7yoilsho	5991	19	pulmonary	pulmonary	JJ
cord-006229-7yoilsho	5991	20	toxicity	toxicity	NN
cord-006229-7yoilsho	5991	21	are	be	VBP
cord-006229-7yoilsho	5991	22	in	in	IN
cord-006229-7yoilsho	5991	23	the	the	DT
cord-006229-7yoilsho	5991	24	focus	focus	NN
cord-006229-7yoilsho	5991	25	of	of	IN
cord-006229-7yoilsho	5991	26	current	current	JJ
cord-006229-7yoilsho	5991	27	research	research	NN
cord-006229-7yoilsho	5991	28	.	.	.
cord-006229-7yoilsho	5992	1	Until	until	IN
cord-006229-7yoilsho	5992	2	now	now	RB
cord-006229-7yoilsho	5992	3	,	,	,
cord-006229-7yoilsho	5992	4	most	most	JJS
cord-006229-7yoilsho	5992	5	of	of	IN
cord-006229-7yoilsho	5992	6	the	the	DT
cord-006229-7yoilsho	5992	7	available	available	JJ
cord-006229-7yoilsho	5992	8	in	in	IN
cord-006229-7yoilsho	5992	9	vitro	vitro	FW
cord-006229-7yoilsho	5992	10	cell	cell	NN
cord-006229-7yoilsho	5992	11	culture	culture	NN
cord-006229-7yoilsho	5992	12	models	model	NNS
cord-006229-7yoilsho	5992	13	are	be	VBP
cord-006229-7yoilsho	5992	14	limited	limit	VBN
cord-006229-7yoilsho	5992	15	to	to	IN
cord-006229-7yoilsho	5992	16	some	some	DT
cord-006229-7yoilsho	5992	17	extent	extent	NN
cord-006229-7yoilsho	5992	18	as	as	IN
cord-006229-7yoilsho	5992	19	in	in	IN
cord-006229-7yoilsho	5992	20	those	those	DT
cord-006229-7yoilsho	5992	21	studies	study	NNS
cord-006229-7yoilsho	5992	22	the	the	DT
cord-006229-7yoilsho	5992	23	exposure	exposure	NN
cord-006229-7yoilsho	5992	24	is	be	VBZ
cord-006229-7yoilsho	5992	25	either	either	CC
cord-006229-7yoilsho	5992	26	done	do	VBN
cord-006229-7yoilsho	5992	27	under	under	IN
cord-006229-7yoilsho	5992	28	submerged	submerged	JJ
cord-006229-7yoilsho	5992	29	conditions	condition	NNS
cord-006229-7yoilsho	5992	30	,	,	,
cord-006229-7yoilsho	5992	31	not	not	RB
cord-006229-7yoilsho	5992	32	resembling	resemble	VBG
cord-006229-7yoilsho	5992	33	the	the	DT
cord-006229-7yoilsho	5992	34	exposure	exposure	NN
cord-006229-7yoilsho	5992	35	conditions	condition	NNS
cord-006229-7yoilsho	5992	36	in	in	IN
cord-006229-7yoilsho	5992	37	vivo	vivo	NN
cord-006229-7yoilsho	5992	38	,	,	,
cord-006229-7yoilsho	5992	39	or	or	CC
cord-006229-7yoilsho	5992	40	a	a	DT
cord-006229-7yoilsho	5992	41	homogeneous	homogeneous	JJ
cord-006229-7yoilsho	5992	42	particle	particle	NN
cord-006229-7yoilsho	5992	43	distribution	distribution	NN
cord-006229-7yoilsho	5992	44	is	be	VBZ
cord-006229-7yoilsho	5992	45	not	not	RB
cord-006229-7yoilsho	5992	46	guaranteed	guarantee	VBN
cord-006229-7yoilsho	5992	47	.	.	.
cord-006229-7yoilsho	5993	1	The	the	DT
cord-006229-7yoilsho	5993	2	CULTEX	CULTEX	NNP
cord-006229-7yoilsho	5993	3	®	®	VBZ
cord-006229-7yoilsho	5993	4	Radial	Radial	NNP
cord-006229-7yoilsho	5993	5	Flow	Flow	NNP
cord-006229-7yoilsho	5993	6	System	System	NNP
cord-006229-7yoilsho	5993	7	(	(	-LRB-
cord-006229-7yoilsho	5993	8	RFS	RFS	NNP
cord-006229-7yoilsho	5993	9	)	)	-RRB-
cord-006229-7yoilsho	5993	10	is	be	VBZ
cord-006229-7yoilsho	5993	11	a	a	DT
cord-006229-7yoilsho	5993	12	specially	specially	RB
cord-006229-7yoilsho	5993	13	designed	design	VBN
cord-006229-7yoilsho	5993	14	in	in	IN
cord-006229-7yoilsho	5993	15	vitro	vitro	FW
cord-006229-7yoilsho	5993	16	modular	modular	JJ
cord-006229-7yoilsho	5993	17	exposure	exposure	NN
cord-006229-7yoilsho	5993	18	system	system	NN
cord-006229-7yoilsho	5993	19	that	that	WDT
cord-006229-7yoilsho	5993	20	overcomes	overcome	VBZ
cord-006229-7yoilsho	5993	21	these	these	DT
cord-006229-7yoilsho	5993	22	limitations	limitation	NNS
cord-006229-7yoilsho	5993	23	.	.	.
cord-006229-7yoilsho	5994	1	It	-PRON-	PRP
cord-006229-7yoilsho	5994	2	enables	enable	VBZ
cord-006229-7yoilsho	5994	3	the	the	DT
cord-006229-7yoilsho	5994	4	homogenous	homogenous	JJ
cord-006229-7yoilsho	5994	5	exposure	exposure	NN
cord-006229-7yoilsho	5994	6	of	of	IN
cord-006229-7yoilsho	5994	7	human	human	JJ
cord-006229-7yoilsho	5994	8	lung	lung	NN
cord-006229-7yoilsho	5994	9	epithelial	epithelial	NN
cord-006229-7yoilsho	5994	10	cells	cell	NNS
cord-006229-7yoilsho	5994	11	at	at	IN
cord-006229-7yoilsho	5994	12	the	the	DT
cord-006229-7yoilsho	5994	13	air	air	NN
cord-006229-7yoilsho	5994	14	-	-	HYPH
cord-006229-7yoilsho	5994	15	liquid	liquid	NN
cord-006229-7yoilsho	5994	16	interface	interface	NN
cord-006229-7yoilsho	5994	17	(	(	-LRB-
cord-006229-7yoilsho	5994	18	ALI	ALI	NNP
cord-006229-7yoilsho	5994	19	)	)	-RRB-
cord-006229-7yoilsho	5994	20	,	,	,
cord-006229-7yoilsho	5994	21	thereby	thereby	RB
cord-006229-7yoilsho	5994	22	mimicking	mimic	VBG
cord-006229-7yoilsho	5994	23	the	the	DT
cord-006229-7yoilsho	5994	24	physiological	physiological	JJ
cord-006229-7yoilsho	5994	25	conditions	condition	NNS
cord-006229-7yoilsho	5994	26	of	of	IN
cord-006229-7yoilsho	5994	27	the	the	DT
cord-006229-7yoilsho	5994	28	alveolae	alveolae	NNS
cord-006229-7yoilsho	5994	29	.	.	.
cord-006229-7yoilsho	5995	1	However	however	RB
cord-006229-7yoilsho	5995	2	,	,	,
cord-006229-7yoilsho	5995	3	further	further	JJ
cord-006229-7yoilsho	5995	4	optimizations	optimization	NNS
cord-006229-7yoilsho	5995	5	are	be	VBP
cord-006229-7yoilsho	5995	6	needed	need	VBN
cord-006229-7yoilsho	5995	7	for	for	IN
cord-006229-7yoilsho	5995	8	the	the	DT
cord-006229-7yoilsho	5995	9	enhancement	enhancement	NN
cord-006229-7yoilsho	5995	10	of	of	IN
cord-006229-7yoilsho	5995	11	the	the	DT
cord-006229-7yoilsho	5995	12	CULTEX	CULTEX	NNP
cord-006229-7yoilsho	5995	13	®	®	NN
cord-006229-7yoilsho	5995	14	methodology	methodology	NN
cord-006229-7yoilsho	5995	15	.	.	.
cord-006229-7yoilsho	5996	1	Aim	aim	VB
cord-006229-7yoilsho	5996	2	of	of	IN
cord-006229-7yoilsho	5996	3	this	this	DT
cord-006229-7yoilsho	5996	4	study	study	NN
cord-006229-7yoilsho	5996	5	was	be	VBD
cord-006229-7yoilsho	5996	6	first	first	RB
cord-006229-7yoilsho	5996	7	the	the	DT
cord-006229-7yoilsho	5996	8	optimization	optimization	NN
cord-006229-7yoilsho	5996	9	of	of	IN
cord-006229-7yoilsho	5996	10	the	the	DT
cord-006229-7yoilsho	5996	11	test	test	NN
cord-006229-7yoilsho	5996	12	methodology	methodology	NN
cord-006229-7yoilsho	5996	13	in	in	IN
cord-006229-7yoilsho	5996	14	general	general	JJ
cord-006229-7yoilsho	5996	15	(	(	-LRB-
cord-006229-7yoilsho	5996	16	i.e.	i.e.	FW
cord-006229-7yoilsho	5996	17	focus	focus	NN
cord-006229-7yoilsho	5996	18	on	on	IN
cord-006229-7yoilsho	5996	19	clean	clean	JJ
cord-006229-7yoilsho	5996	20	air	air	NN
cord-006229-7yoilsho	5996	21	controls	control	NNS
cord-006229-7yoilsho	5996	22	of	of	IN
cord-006229-7yoilsho	5996	23	the	the	DT
cord-006229-7yoilsho	5996	24	human	human	JJ
cord-006229-7yoilsho	5996	25	lung	lung	NN
cord-006229-7yoilsho	5996	26	epithelial	epithelial	JJ
cord-006229-7yoilsho	5996	27	cell	cell	NN
cord-006229-7yoilsho	5996	28	line	line	NN
cord-006229-7yoilsho	5996	29	A549	A549	''
cord-006229-7yoilsho	5996	30	)	)	-RRB-
cord-006229-7yoilsho	5996	31	,	,	,
cord-006229-7yoilsho	5996	32	and	and	CC
cord-006229-7yoilsho	5996	33	second	second	JJ
cord-006229-7yoilsho	5996	34	the	the	DT
cord-006229-7yoilsho	5996	35	improvement	improvement	NN
cord-006229-7yoilsho	5996	36	of	of	IN
cord-006229-7yoilsho	5996	37	cultivation	cultivation	NN
cord-006229-7yoilsho	5996	38	conditions	condition	NNS
cord-006229-7yoilsho	5996	39	.	.	.
cord-006229-7yoilsho	5997	1	Parameters	parameter	NNS
cord-006229-7yoilsho	5997	2	such	such	JJ
cord-006229-7yoilsho	5997	3	as	as	IN
cord-006229-7yoilsho	5997	4	handling	handling	NN
cord-006229-7yoilsho	5997	5	of	of	IN
cord-006229-7yoilsho	5997	6	the	the	DT
cord-006229-7yoilsho	5997	7	CULTEX	CULTEX	NNP
cord-006229-7yoilsho	5997	8	®	®	POS
cord-006229-7yoilsho	5997	9	device	device	NN
cord-006229-7yoilsho	5997	10	(	(	-LRB-
cord-006229-7yoilsho	5997	11	proper	proper	JJ
cord-006229-7yoilsho	5997	12	closing	closing	NN
cord-006229-7yoilsho	5997	13	and	and	CC
cord-006229-7yoilsho	5997	14	opening	opening	NN
cord-006229-7yoilsho	5997	15	operation	operation	NN
cord-006229-7yoilsho	5997	16	of	of	IN
cord-006229-7yoilsho	5997	17	the	the	DT
cord-006229-7yoilsho	5997	18	CULTEX	CULTEX	NNP
cord-006229-7yoilsho	5998	1	®	®	,
cord-006229-7yoilsho	5998	2	RFS	RFS	NNP
cord-006229-7yoilsho	5998	3	module	module	NN
cord-006229-7yoilsho	5998	4	;	;	:
cord-006229-7yoilsho	5998	5	improved	improve	VBN
cord-006229-7yoilsho	5998	6	washing	washing	NN
cord-006229-7yoilsho	5998	7	conditions	condition	NNS
cord-006229-7yoilsho	5998	8	and	and	CC
cord-006229-7yoilsho	5998	9	media	medium	NNS
cord-006229-7yoilsho	5998	10	supply	supply	NN
cord-006229-7yoilsho	5998	11	)	)	-RRB-
cord-006229-7yoilsho	5998	12	,	,	,
cord-006229-7yoilsho	5998	13	treatment	treatment	NN
cord-006229-7yoilsho	5998	14	of	of	IN
cord-006229-7yoilsho	5998	15	the	the	DT
cord-006229-7yoilsho	5998	16	incubator	incubator	NN
cord-006229-7yoilsho	5998	17	controls	control	NNS
cord-006229-7yoilsho	5998	18	,	,	,
cord-006229-7yoilsho	5998	19	adjustment	adjustment	NN
cord-006229-7yoilsho	5998	20	of	of	IN
cord-006229-7yoilsho	5998	21	clean	clean	JJ
cord-006229-7yoilsho	5998	22	air	air	NN
cord-006229-7yoilsho	5998	23	pressure	pressure	NN
cord-006229-7yoilsho	5998	24	and	and	CC
cord-006229-7yoilsho	5998	25	flow	flow	NN
cord-006229-7yoilsho	5998	26	rates	rate	NNS
cord-006229-7yoilsho	5998	27	,	,	,
cord-006229-7yoilsho	5998	28	and	and	CC
cord-006229-7yoilsho	5998	29	integration	integration	NN
cord-006229-7yoilsho	5998	30	of	of	IN
cord-006229-7yoilsho	5998	31	two	two	CD
cord-006229-7yoilsho	5998	32	additional	additional	JJ
cord-006229-7yoilsho	5998	33	filters	filter	NNS
cord-006229-7yoilsho	5998	34	were	be	VBD
cord-006229-7yoilsho	5998	35	sequentially	sequentially	RB
cord-006229-7yoilsho	5998	36	adjusted	adjust	VBN
cord-006229-7yoilsho	5998	37	in	in	IN
cord-006229-7yoilsho	5998	38	order	order	NN
cord-006229-7yoilsho	5998	39	to	to	TO
cord-006229-7yoilsho	5998	40	enhance	enhance	VB
cord-006229-7yoilsho	5998	41	the	the	DT
cord-006229-7yoilsho	5998	42	methodical	methodical	JJ
cord-006229-7yoilsho	5998	43	setup	setup	NN
cord-006229-7yoilsho	5998	44	.	.	.
cord-006229-7yoilsho	5999	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	5999	2	results	result	NNS
cord-006229-7yoilsho	5999	3	show	show	VBP
cord-006229-7yoilsho	5999	4	that	that	IN
cord-006229-7yoilsho	5999	5	the	the	DT
cord-006229-7yoilsho	5999	6	test	test	NN
cord-006229-7yoilsho	5999	7	parameters	parameter	NNS
cord-006229-7yoilsho	5999	8	for	for	IN
cord-006229-7yoilsho	5999	9	clean	clean	JJ
cord-006229-7yoilsho	5999	10	air	air	NN
cord-006229-7yoilsho	5999	11	exposure	exposure	NN
cord-006229-7yoilsho	5999	12	of	of	IN
cord-006229-7yoilsho	5999	13	the	the	DT
cord-006229-7yoilsho	5999	14	A549	A549	NNP
cord-006229-7yoilsho	5999	15	cells	cell	NNS
cord-006229-7yoilsho	5999	16	were	be	VBD
cord-006229-7yoilsho	5999	17	successfully	successfully	RB
cord-006229-7yoilsho	5999	18	optimized	optimize	VBN
cord-006229-7yoilsho	5999	19	resulting	result	VBG
cord-006229-7yoilsho	5999	20	in	in	IN
cord-006229-7yoilsho	5999	21	more	more	RBR
cord-006229-7yoilsho	5999	22	accurate	accurate	JJ
cord-006229-7yoilsho	5999	23	and	and	CC
cord-006229-7yoilsho	5999	24	robust	robust	JJ
cord-006229-7yoilsho	5999	25	data	datum	NNS
cord-006229-7yoilsho	5999	26	.	.	.
cord-006229-7yoilsho	6000	1	Cultivation	cultivation	NN
cord-006229-7yoilsho	6000	2	conditions	condition	NNS
cord-006229-7yoilsho	6000	3	were	be	VBD
cord-006229-7yoilsho	6000	4	improved	improve	VBN
cord-006229-7yoilsho	6000	5	by	by	IN
cord-006229-7yoilsho	6000	6	changing	change	VBG
cord-006229-7yoilsho	6000	7	from	from	IN
cord-006229-7yoilsho	6000	8	closed	closed	JJ
cord-006229-7yoilsho	6000	9	-	-	HYPH
cord-006229-7yoilsho	6000	10	wall	wall	NN
cord-006229-7yoilsho	6000	11	cell	cell	NN
cord-006229-7yoilsho	6000	12	culture	culture	NN
cord-006229-7yoilsho	6000	13	inserts	insert	NNS
cord-006229-7yoilsho	6000	14	to	to	TO
cord-006229-7yoilsho	6000	15	open	open	VB
cord-006229-7yoilsho	6000	16	-	-	HYPH
cord-006229-7yoilsho	6000	17	wall	wall	NN
cord-006229-7yoilsho	6000	18	cell	cell	NN
cord-006229-7yoilsho	6000	19	culture	culture	NN
cord-006229-7yoilsho	6000	20	inserts	insert	NNS
cord-006229-7yoilsho	6000	21	.	.	.
cord-006229-7yoilsho	6001	1	The	the	DT
cord-006229-7yoilsho	6001	2	openwall	openwall	NN
cord-006229-7yoilsho	6001	3	inserts	insert	NNS
cord-006229-7yoilsho	6001	4	turned	turn	VBD
cord-006229-7yoilsho	6001	5	out	out	RP
cord-006229-7yoilsho	6001	6	to	to	TO
cord-006229-7yoilsho	6001	7	be	be	VB
cord-006229-7yoilsho	6001	8	more	more	RBR
cord-006229-7yoilsho	6001	9	suitable	suitable	JJ
cord-006229-7yoilsho	6001	10	for	for	IN
cord-006229-7yoilsho	6001	11	exposure	exposure	NN
cord-006229-7yoilsho	6001	12	experiments	experiment	NNS
cord-006229-7yoilsho	6001	13	as	as	IN
cord-006229-7yoilsho	6001	14	they	-PRON-	PRP
cord-006229-7yoilsho	6001	15	provided	provide	VBD
cord-006229-7yoilsho	6001	16	a	a	DT
cord-006229-7yoilsho	6001	17	better	well	JJR
cord-006229-7yoilsho	6001	18	medium	medium	JJ
cord-006229-7yoilsho	6001	19	supply	supply	NN
cord-006229-7yoilsho	6001	20	and	and	CC
cord-006229-7yoilsho	6001	21	preserved	preserve	VBN
cord-006229-7yoilsho	6001	22	humidity	humidity	NN
cord-006229-7yoilsho	6001	23	.	.	.
cord-006229-7yoilsho	6002	1	Deductive	deductive	JJ
cord-006229-7yoilsho	6002	2	,	,	,
cord-006229-7yoilsho	6002	3	the	the	DT
cord-006229-7yoilsho	6002	4	change	change	NN
cord-006229-7yoilsho	6002	5	of	of	IN
cord-006229-7yoilsho	6002	6	the	the	DT
cord-006229-7yoilsho	6002	7	cell	cell	NN
cord-006229-7yoilsho	6002	8	culture	culture	NN
cord-006229-7yoilsho	6002	9	inserts	insert	NNS
cord-006229-7yoilsho	6002	10	was	be	VBD
cord-006229-7yoilsho	6002	11	identified	identify	VBN
cord-006229-7yoilsho	6002	12	as	as	IN
cord-006229-7yoilsho	6002	13	the	the	DT
cord-006229-7yoilsho	6002	14	deciding	decide	VBG
cord-006229-7yoilsho	6002	15	factor	factor	NN
cord-006229-7yoilsho	6002	16	for	for	IN
cord-006229-7yoilsho	6002	17	the	the	DT
cord-006229-7yoilsho	6002	18	improvement	improvement	NN
cord-006229-7yoilsho	6002	19	of	of	IN
cord-006229-7yoilsho	6002	20	cell	cell	NN
cord-006229-7yoilsho	6002	21	morphology	morphology	NN
cord-006229-7yoilsho	6002	22	.	.	.
cord-006229-7yoilsho	6003	1	Hence	hence	RB
cord-006229-7yoilsho	6003	2	,	,	,
cord-006229-7yoilsho	6003	3	we	-PRON-	PRP
cord-006229-7yoilsho	6003	4	have	have	VBP
cord-006229-7yoilsho	6003	5	successfully	successfully	RB
cord-006229-7yoilsho	6003	6	optimized	optimize	VBN
cord-006229-7yoilsho	6003	7	the	the	DT
cord-006229-7yoilsho	6003	8	CULTEX	CULTEX	NNP
cord-006229-7yoilsho	6003	9	®	®	POS
cord-006229-7yoilsho	6003	10	RFS	RFS	NNP
cord-006229-7yoilsho	6003	11	methodology	methodology	NN
cord-006229-7yoilsho	6003	12	for	for	IN
cord-006229-7yoilsho	6003	13	clean	clean	JJ
cord-006229-7yoilsho	6003	14	air	air	NN
cord-006229-7yoilsho	6003	15	exposure	exposure	NN
cord-006229-7yoilsho	6003	16	of	of	IN
cord-006229-7yoilsho	6003	17	A549	a549	JJ
cord-006229-7yoilsho	6003	18	cells	cell	NNS
cord-006229-7yoilsho	6003	19	.	.	.
cord-006229-7yoilsho	6004	1	Human	human	JJ
cord-006229-7yoilsho	6004	2	primary	primary	JJ
cord-006229-7yoilsho	6004	3	hepatocytes	hepatocyte	NNS
cord-006229-7yoilsho	6004	4	represent	represent	VBP
cord-006229-7yoilsho	6004	5	the	the	DT
cord-006229-7yoilsho	6004	6	gold	gold	NN
cord-006229-7yoilsho	6004	7	standard	standard	NN
cord-006229-7yoilsho	6004	8	in	in	IN
cord-006229-7yoilsho	6004	9	in	in	FW
cord-006229-7yoilsho	6004	10	vitro	vitro	FW
cord-006229-7yoilsho	6004	11	liver	liver	NN
cord-006229-7yoilsho	6004	12	research	research	NN
cord-006229-7yoilsho	6004	13	.	.	.
cord-006229-7yoilsho	6005	1	Due	due	IN
cord-006229-7yoilsho	6005	2	to	to	IN
cord-006229-7yoilsho	6005	3	their	-PRON-	PRP$
cord-006229-7yoilsho	6005	4	low	low	JJ
cord-006229-7yoilsho	6005	5	availability	availability	NN
cord-006229-7yoilsho	6005	6	and	and	CC
cord-006229-7yoilsho	6005	7	high	high	JJ
cord-006229-7yoilsho	6005	8	costs	cost	NNS
cord-006229-7yoilsho	6005	9	,	,	,
cord-006229-7yoilsho	6005	10	alternative	alternative	JJ
cord-006229-7yoilsho	6005	11	liver	liver	NN
cord-006229-7yoilsho	6005	12	cell	cell	NN
cord-006229-7yoilsho	6005	13	models	model	NNS
cord-006229-7yoilsho	6005	14	with	with	IN
cord-006229-7yoilsho	6005	15	comparable	comparable	JJ
cord-006229-7yoilsho	6005	16	morphological	morphological	JJ
cord-006229-7yoilsho	6005	17	and	and	CC
cord-006229-7yoilsho	6005	18	biochemical	biochemical	JJ
cord-006229-7yoilsho	6005	19	characteristics	characteristic	NNS
cord-006229-7yoilsho	6005	20	have	have	VBP
cord-006229-7yoilsho	6005	21	come	come	VBN
cord-006229-7yoilsho	6005	22	into	into	IN
cord-006229-7yoilsho	6005	23	focus	focus	NN
cord-006229-7yoilsho	6005	24	.	.	.
cord-006229-7yoilsho	6006	1	The	the	DT
cord-006229-7yoilsho	6006	2	human	human	JJ
cord-006229-7yoilsho	6006	3	hepatocarcinoma	hepatocarcinoma	NNP
cord-006229-7yoilsho	6006	4	cell	cell	NN
cord-006229-7yoilsho	6006	5	line	line	NN
cord-006229-7yoilsho	6006	6	HepG2	HepG2	NNP
cord-006229-7yoilsho	6006	7	is	be	VBZ
cord-006229-7yoilsho	6006	8	often	often	RB
cord-006229-7yoilsho	6006	9	used	use	VBN
cord-006229-7yoilsho	6006	10	as	as	IN
cord-006229-7yoilsho	6006	11	a	a	DT
cord-006229-7yoilsho	6006	12	model	model	NN
cord-006229-7yoilsho	6006	13	for	for	IN
cord-006229-7yoilsho	6006	14	liver	liver	NN
cord-006229-7yoilsho	6006	15	toxicity	toxicity	NN
cord-006229-7yoilsho	6006	16	studies	study	NNS
cord-006229-7yoilsho	6006	17	.	.	.
cord-006229-7yoilsho	6007	1	However	however	RB
cord-006229-7yoilsho	6007	2	,	,	,
cord-006229-7yoilsho	6007	3	under	under	IN
cord-006229-7yoilsho	6007	4	two	two	CD
cord-006229-7yoilsho	6007	5	-	-	HYPH
cord-006229-7yoilsho	6007	6	dimensional	dimensional	JJ
cord-006229-7yoilsho	6007	7	(	(	-LRB-
cord-006229-7yoilsho	6007	8	2D	2D	NNP
cord-006229-7yoilsho	6007	9	)	)	-RRB-
cord-006229-7yoilsho	6007	10	cultivation	cultivation	NN
cord-006229-7yoilsho	6007	11	conditions	condition	NNS
cord-006229-7yoilsho	6007	12	the	the	DT
cord-006229-7yoilsho	6007	13	expression	expression	NN
cord-006229-7yoilsho	6007	14	of	of	IN
cord-006229-7yoilsho	6007	15	xenobiotic	xenobiotic	NN
cord-006229-7yoilsho	6007	16	-	-	HYPH
cord-006229-7yoilsho	6007	17	metabolizing	metabolize	VBG
cord-006229-7yoilsho	6007	18	enzymes	enzyme	NNS
cord-006229-7yoilsho	6007	19	and	and	CC
cord-006229-7yoilsho	6007	20	typical	typical	JJ
cord-006229-7yoilsho	6007	21	liver	liver	NN
cord-006229-7yoilsho	6007	22	markers	marker	NNS
cord-006229-7yoilsho	6007	23	is	be	VBZ
cord-006229-7yoilsho	6007	24	very	very	RB
cord-006229-7yoilsho	6007	25	low	low	JJ
cord-006229-7yoilsho	6007	26	.	.	.
cord-006229-7yoilsho	6008	1	Cultivation	cultivation	NN
cord-006229-7yoilsho	6008	2	for	for	IN
cord-006229-7yoilsho	6008	3	21	21	CD
cord-006229-7yoilsho	6008	4	days	day	NNS
cord-006229-7yoilsho	6008	5	in	in	IN
cord-006229-7yoilsho	6008	6	a	a	DT
cord-006229-7yoilsho	6008	7	three	three	CD
cord-006229-7yoilsho	6008	8	-	-	HYPH
cord-006229-7yoilsho	6008	9	dimensional	dimensional	JJ
cord-006229-7yoilsho	6008	10	(	(	-LRB-
cord-006229-7yoilsho	6008	11	3D	3D	NNP
cord-006229-7yoilsho	6008	12	)	)	-RRB-
cord-006229-7yoilsho	6008	13	matrigel	matrigel	NNP
cord-006229-7yoilsho	6008	14	culture	culture	NN
cord-006229-7yoilsho	6008	15	system	system	NN
cord-006229-7yoilsho	6008	16	has	have	VBZ
cord-006229-7yoilsho	6008	17	been	be	VBN
cord-006229-7yoilsho	6008	18	reported	report	VBN
cord-006229-7yoilsho	6008	19	to	to	TO
cord-006229-7yoilsho	6008	20	strongly	strongly	RB
cord-006229-7yoilsho	6008	21	increase	increase	VB
cord-006229-7yoilsho	6008	22	the	the	DT
cord-006229-7yoilsho	6008	23	metabolic	metabolic	JJ
cord-006229-7yoilsho	6008	24	competency	competency	NN
cord-006229-7yoilsho	6008	25	of	of	IN
cord-006229-7yoilsho	6008	26	HepG2	HepG2	NNP
cord-006229-7yoilsho	6008	27	cells	cell	NNS
cord-006229-7yoilsho	6008	28	.	.	.
cord-006229-7yoilsho	6009	1	In	in	IN
cord-006229-7yoilsho	6009	2	our	-PRON-	PRP$
cord-006229-7yoilsho	6009	3	present	present	JJ
cord-006229-7yoilsho	6009	4	study	study	NN
cord-006229-7yoilsho	6009	5	we	-PRON-	PRP
cord-006229-7yoilsho	6009	6	extended	extend	VBD
cord-006229-7yoilsho	6009	7	previous	previous	JJ
cord-006229-7yoilsho	6009	8	studies	study	NNS
cord-006229-7yoilsho	6009	9	and	and	CC
cord-006229-7yoilsho	6009	10	compared	compare	VBD
cord-006229-7yoilsho	6009	11	HepG2	HepG2	NNP
cord-006229-7yoilsho	6009	12	cell	cell	NN
cord-006229-7yoilsho	6009	13	cultivation	cultivation	NN
cord-006229-7yoilsho	6009	14	in	in	IN
cord-006229-7yoilsho	6009	15	three	three	CD
cord-006229-7yoilsho	6009	16	different	different	JJ
cord-006229-7yoilsho	6009	17	3D	3d	JJ
cord-006229-7yoilsho	6009	18	culture	culture	NN
cord-006229-7yoilsho	6009	19	systems	system	NNS
cord-006229-7yoilsho	6009	20	:	:	:
cord-006229-7yoilsho	6009	21	collagen	collagen	NN
cord-006229-7yoilsho	6009	22	,	,	,
cord-006229-7yoilsho	6009	23	matrigel	matrigel	NN
cord-006229-7yoilsho	6009	24	and	and	CC
cord-006229-7yoilsho	6009	25	Alvetex	Alvetex	NNP
cord-006229-7yoilsho	6009	26	culture	culture	NN
cord-006229-7yoilsho	6009	27	system	system	NN
cord-006229-7yoilsho	6009	28	.	.	.
cord-006229-7yoilsho	6010	1	Cell	cell	NN
cord-006229-7yoilsho	6010	2	morphology	morphology	NN
cord-006229-7yoilsho	6010	3	,	,	,
cord-006229-7yoilsho	6010	4	albumin	albumin	NN
cord-006229-7yoilsho	6010	5	secretion	secretion	NN
cord-006229-7yoilsho	6010	6	,	,	,
cord-006229-7yoilsho	6010	7	cytochrome	cytochrome	NN
cord-006229-7yoilsho	6010	8	P450	p450	JJ
cord-006229-7yoilsho	6010	9	monooxygenase	monooxygenase	NN
cord-006229-7yoilsho	6010	10	(	(	-LRB-
cord-006229-7yoilsho	6010	11	CYP	CYP	NNP
cord-006229-7yoilsho	6010	12	)	)	-RRB-
cord-006229-7yoilsho	6010	13	enzyme	enzyme	NN
cord-006229-7yoilsho	6010	14	activities	activity	NNS
cord-006229-7yoilsho	6010	15	,	,	,
cord-006229-7yoilsho	6010	16	as	as	RB
cord-006229-7yoilsho	6010	17	well	well	RB
cord-006229-7yoilsho	6010	18	as	as	IN
cord-006229-7yoilsho	6010	19	expression	expression	NN
cord-006229-7yoilsho	6010	20	of	of	IN
cord-006229-7yoilsho	6010	21	xenobiotic	xenobiotic	NN
cord-006229-7yoilsho	6010	22	-	-	HYPH
cord-006229-7yoilsho	6010	23	metabolizing	metabolize	VBG
cord-006229-7yoilsho	6010	24	and	and	CC
cord-006229-7yoilsho	6010	25	liver	liver	NN
cord-006229-7yoilsho	6010	26	-	-	HYPH
cord-006229-7yoilsho	6010	27	specific	specific	JJ
cord-006229-7yoilsho	6010	28	enzymes	enzyme	NNS
cord-006229-7yoilsho	6010	29	were	be	VBD
cord-006229-7yoilsho	6010	30	analyzed	analyze	VBN
cord-006229-7yoilsho	6010	31	after	after	IN
cord-006229-7yoilsho	6010	32	3	3	CD
cord-006229-7yoilsho	6010	33	,	,	,
cord-006229-7yoilsho	6010	34	7	7	CD
cord-006229-7yoilsho	6010	35	,	,	,
cord-006229-7yoilsho	6010	36	14	14	CD
cord-006229-7yoilsho	6010	37	,	,	,
cord-006229-7yoilsho	6010	38	and	and	CC
cord-006229-7yoilsho	6010	39	21	21	CD
cord-006229-7yoilsho	6010	40	days	day	NNS
cord-006229-7yoilsho	6010	41	of	of	IN
cord-006229-7yoilsho	6010	42	cultivation	cultivation	NN
cord-006229-7yoilsho	6010	43	.	.	.
cord-006229-7yoilsho	6011	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	6011	2	results	result	NNS
cord-006229-7yoilsho	6011	3	show	show	VBP
cord-006229-7yoilsho	6011	4	that	that	IN
cord-006229-7yoilsho	6011	5	the	the	DT
cord-006229-7yoilsho	6011	6	previously	previously	RB
cord-006229-7yoilsho	6011	7	reported	report	VBN
cord-006229-7yoilsho	6011	8	increase	increase	NN
cord-006229-7yoilsho	6011	9	of	of	IN
cord-006229-7yoilsho	6011	10	metabolic	metabolic	JJ
cord-006229-7yoilsho	6011	11	competency	competency	NN
cord-006229-7yoilsho	6011	12	of	of	IN
cord-006229-7yoilsho	6011	13	HepG2	HepG2	NNP
cord-006229-7yoilsho	6011	14	cells	cell	NNS
cord-006229-7yoilsho	6011	15	is	be	VBZ
cord-006229-7yoilsho	6011	16	not	not	RB
cord-006229-7yoilsho	6011	17	primarily	primarily	RB
cord-006229-7yoilsho	6011	18	the	the	DT
cord-006229-7yoilsho	6011	19	result	result	NN
cord-006229-7yoilsho	6011	20	of	of	IN
cord-006229-7yoilsho	6011	21	3D	3d	JJ
cord-006229-7yoilsho	6011	22	culture	culture	NN
cord-006229-7yoilsho	6011	23	but	but	CC
cord-006229-7yoilsho	6011	24	a	a	DT
cord-006229-7yoilsho	6011	25	consequence	consequence	NN
cord-006229-7yoilsho	6011	26	of	of	IN
cord-006229-7yoilsho	6011	27	the	the	DT
cord-006229-7yoilsho	6011	28	duration	duration	NN
cord-006229-7yoilsho	6011	29	of	of	IN
cord-006229-7yoilsho	6011	30	cultivation	cultivation	NN
cord-006229-7yoilsho	6011	31	.	.	.
cord-006229-7yoilsho	6012	1	HepG2	HepG2	NNP
cord-006229-7yoilsho	6012	2	cells	cell	NNS
cord-006229-7yoilsho	6012	3	grown	grow	VBN
cord-006229-7yoilsho	6012	4	for	for	IN
cord-006229-7yoilsho	6012	5	21	21	CD
cord-006229-7yoilsho	6012	6	days	day	NNS
cord-006229-7yoilsho	6012	7	in	in	IN
cord-006229-7yoilsho	6012	8	2D	2d	NN
cord-006229-7yoilsho	6012	9	monolayer	monolayer	NN
cord-006229-7yoilsho	6013	1	exhibit	exhibit	VB
cord-006229-7yoilsho	6013	2	comparable	comparable	JJ
cord-006229-7yoilsho	6013	3	biochemical	biochemical	JJ
cord-006229-7yoilsho	6013	4	characteristics	characteristic	NNS
cord-006229-7yoilsho	6013	5	,	,	,
cord-006229-7yoilsho	6013	6	CYP	CYP	NNP
cord-006229-7yoilsho	6013	7	activities	activity	NNS
cord-006229-7yoilsho	6013	8	and	and	CC
cord-006229-7yoilsho	6013	9	gene	gene	NN
cord-006229-7yoilsho	6013	10	expression	expression	NN
cord-006229-7yoilsho	6013	11	patterns	pattern	NNS
cord-006229-7yoilsho	6013	12	as	as	IN
cord-006229-7yoilsho	6013	13	all	all	DT
cord-006229-7yoilsho	6013	14	3D	3d	JJ
cord-006229-7yoilsho	6013	15	culture	culture	NN
cord-006229-7yoilsho	6013	16	systems	system	NNS
cord-006229-7yoilsho	6013	17	used	use	VBN
cord-006229-7yoilsho	6013	18	in	in	IN
cord-006229-7yoilsho	6013	19	our	-PRON-	PRP$
cord-006229-7yoilsho	6013	20	study	study	NN
cord-006229-7yoilsho	6013	21	.	.	.
cord-006229-7yoilsho	6014	1	However	however	RB
cord-006229-7yoilsho	6014	2	,	,	,
cord-006229-7yoilsho	6014	3	CYP	CYP	NNP
cord-006229-7yoilsho	6014	4	activities	activity	NNS
cord-006229-7yoilsho	6014	5	did	do	VBD
cord-006229-7yoilsho	6014	6	not	not	RB
cord-006229-7yoilsho	6014	7	reach	reach	VB
cord-006229-7yoilsho	6014	8	the	the	DT
cord-006229-7yoilsho	6014	9	level	level	NN
cord-006229-7yoilsho	6014	10	of	of	IN
cord-006229-7yoilsho	6014	11	HepaRG	HepaRG	NNP
cord-006229-7yoilsho	6014	12	cells	cell	NNS
cord-006229-7yoilsho	6014	13	.	.	.
cord-006229-7yoilsho	6015	1	In	in	IN
cord-006229-7yoilsho	6015	2	conclusion	conclusion	NN
cord-006229-7yoilsho	6015	3	,	,	,
cord-006229-7yoilsho	6015	4	the	the	DT
cord-006229-7yoilsho	6015	5	increase	increase	NN
cord-006229-7yoilsho	6015	6	of	of	IN
cord-006229-7yoilsho	6015	7	metabolic	metabolic	JJ
cord-006229-7yoilsho	6015	8	competence	competence	NN
cord-006229-7yoilsho	6015	9	of	of	IN
cord-006229-7yoilsho	6015	10	the	the	DT
cord-006229-7yoilsho	6015	11	hepatocarcinoma	hepatocarcinoma	NNP
cord-006229-7yoilsho	6015	12	cell	cell	NN
cord-006229-7yoilsho	6015	13	line	line	NN
cord-006229-7yoilsho	6015	14	HepG2	HepG2	NNP
cord-006229-7yoilsho	6015	15	is	be	VBZ
cord-006229-7yoilsho	6015	16	not	not	RB
cord-006229-7yoilsho	6015	17	due	due	JJ
cord-006229-7yoilsho	6015	18	to	to	IN
cord-006229-7yoilsho	6015	19	3D	3d	JJ
cord-006229-7yoilsho	6015	20	cultivation	cultivation	NN
cord-006229-7yoilsho	6015	21	but	but	CC
cord-006229-7yoilsho	6015	22	rather	rather	RB
cord-006229-7yoilsho	6015	23	a	a	DT
cord-006229-7yoilsho	6015	24	result	result	NN
cord-006229-7yoilsho	6015	25	of	of	IN
cord-006229-7yoilsho	6015	26	prolonged	prolonged	JJ
cord-006229-7yoilsho	6015	27	cultivation	cultivation	NN
cord-006229-7yoilsho	6015	28	time	time	NN
cord-006229-7yoilsho	6015	29	.	.	.
cord-006229-7yoilsho	6016	1	In	in	IN
cord-006229-7yoilsho	6016	2	vitro	vitro	FW
cord-006229-7yoilsho	6016	3	assessment	assessment	NN
cord-006229-7yoilsho	6016	4	of	of	IN
cord-006229-7yoilsho	6016	5	the	the	DT
cord-006229-7yoilsho	6016	6	neurotoxic	neurotoxic	JJ
cord-006229-7yoilsho	6016	7	potential	potential	NN
cord-006229-7yoilsho	6016	8	of	of	IN
cord-006229-7yoilsho	6016	9	arsenolipids	arsenolipid	NNS
cord-006229-7yoilsho	6016	10	Arsenolipids	Arsenolipids	NNP
cord-006229-7yoilsho	6016	11	are	be	VBP
cord-006229-7yoilsho	6016	12	organic	organic	JJ
cord-006229-7yoilsho	6016	13	,	,	,
cord-006229-7yoilsho	6016	14	lipid	lipid	NN
cord-006229-7yoilsho	6016	15	-	-	HYPH
cord-006229-7yoilsho	6016	16	soluble	soluble	JJ
cord-006229-7yoilsho	6016	17	arsenic	arsenic	NN
cord-006229-7yoilsho	6016	18	compounds	compound	NNS
cord-006229-7yoilsho	6016	19	,	,	,
cord-006229-7yoilsho	6016	20	which	which	WDT
cord-006229-7yoilsho	6016	21	occur	occur	VBP
cord-006229-7yoilsho	6016	22	mainly	mainly	RB
cord-006229-7yoilsho	6016	23	in	in	IN
cord-006229-7yoilsho	6016	24	marine	marine	JJ
cord-006229-7yoilsho	6016	25	organisms	organism	NNS
cord-006229-7yoilsho	6016	26	.	.	.
cord-006229-7yoilsho	6017	1	Major	major	JJ
cord-006229-7yoilsho	6017	2	human	human	JJ
cord-006229-7yoilsho	6017	3	exposure	exposure	NN
cord-006229-7yoilsho	6017	4	routes	route	NNS
cord-006229-7yoilsho	6017	5	are	be	VBP
cord-006229-7yoilsho	6017	6	fatty	fatty	JJ
cord-006229-7yoilsho	6017	7	fish	fish	NN
cord-006229-7yoilsho	6017	8	including	include	VBG
cord-006229-7yoilsho	6017	9	herring	herring	NN
cord-006229-7yoilsho	6017	10	or	or	CC
cord-006229-7yoilsho	6017	11	fish	fish	NN
cord-006229-7yoilsho	6017	12	oil	oil	NN
cord-006229-7yoilsho	6017	13	-	-	HYPH
cord-006229-7yoilsho	6017	14	based	base	VBN
cord-006229-7yoilsho	6017	15	food	food	NN
cord-006229-7yoilsho	6017	16	supplements	supplement	NNS
cord-006229-7yoilsho	6017	17	.	.	.
cord-006229-7yoilsho	6018	1	About	about	RB
cord-006229-7yoilsho	6018	2	55	55	CD
cord-006229-7yoilsho	6018	3	different	different	JJ
cord-006229-7yoilsho	6018	4	arsenolipids	arsenolipid	NNS
cord-006229-7yoilsho	6018	5	have	have	VBP
cord-006229-7yoilsho	6018	6	been	be	VBN
cord-006229-7yoilsho	6018	7	identified	identify	VBN
cord-006229-7yoilsho	6018	8	so	so	RB
cord-006229-7yoilsho	6018	9	far	far	RB
cord-006229-7yoilsho	6018	10	.	.	.
cord-006229-7yoilsho	6019	1	Thereby	thereby	RB
cord-006229-7yoilsho	6019	2	,	,	,
cord-006229-7yoilsho	6019	3	arsenic	arsenic	NN
cord-006229-7yoilsho	6019	4	-	-	HYPH
cord-006229-7yoilsho	6019	5	containing	contain	VBG
cord-006229-7yoilsho	6019	6	hydrocarbons	hydrocarbon	NNS
cord-006229-7yoilsho	6019	7	(	(	-LRB-
cord-006229-7yoilsho	6019	8	AsHC	AsHC	NNP
cord-006229-7yoilsho	6019	9	)	)	-RRB-
cord-006229-7yoilsho	6019	10	and	and	CC
cord-006229-7yoilsho	6019	11	arsenic	arsenic	NN
cord-006229-7yoilsho	6019	12	-	-	HYPH
cord-006229-7yoilsho	6019	13	containing	contain	VBG
cord-006229-7yoilsho	6019	14	fatty	fatty	JJ
cord-006229-7yoilsho	6019	15	acids	acid	NNS
cord-006229-7yoilsho	6019	16	(	(	-LRB-
cord-006229-7yoilsho	6019	17	AsFA	AsFA	NNP
cord-006229-7yoilsho	6019	18	)	)	-RRB-
cord-006229-7yoilsho	6019	19	represent	represent	VBP
cord-006229-7yoilsho	6019	20	two	two	CD
cord-006229-7yoilsho	6019	21	subgroups	subgroup	NNS
cord-006229-7yoilsho	6019	22	of	of	IN
cord-006229-7yoilsho	6019	23	the	the	DT
cord-006229-7yoilsho	6019	24	arsenolipids	arsenolipid	NNS
cord-006229-7yoilsho	6019	25	[	[	-LRB-
cord-006229-7yoilsho	6019	26	1	1	CD
cord-006229-7yoilsho	6019	27	]	]	-RRB-
cord-006229-7yoilsho	6019	28	.	.	.
cord-006229-7yoilsho	6020	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	6020	2	in	in	FW
cord-006229-7yoilsho	6020	3	vitro	vitro	FW
cord-006229-7yoilsho	6020	4	studies	study	NNS
cord-006229-7yoilsho	6020	5	have	have	VBP
cord-006229-7yoilsho	6020	6	demonstrated	demonstrate	VBN
cord-006229-7yoilsho	6020	7	high	high	JJ
cord-006229-7yoilsho	6020	8	cellular	cellular	JJ
cord-006229-7yoilsho	6020	9	bioavailability	bioavailability	NN
cord-006229-7yoilsho	6020	10	and	and	CC
cord-006229-7yoilsho	6020	11	a	a	DT
cord-006229-7yoilsho	6020	12	high	high	JJ
cord-006229-7yoilsho	6020	13	cytotoxic	cytotoxic	JJ
cord-006229-7yoilsho	6020	14	potential	potential	NN
cord-006229-7yoilsho	6020	15	of	of	IN
cord-006229-7yoilsho	6020	16	AsHCs	ashcs	PRP
cord-006229-7yoilsho	6020	17	in	in	IN
cord-006229-7yoilsho	6020	18	human	human	JJ
cord-006229-7yoilsho	6020	19	liver	liver	NN
cord-006229-7yoilsho	6020	20	and	and	CC
cord-006229-7yoilsho	6020	21	bladder	bladder	NN
cord-006229-7yoilsho	6020	22	cells	cell	NNS
cord-006229-7yoilsho	6020	23	[	[	-LRB-
cord-006229-7yoilsho	6020	24	2	2	CD
cord-006229-7yoilsho	6020	25	]	]	-RRB-
cord-006229-7yoilsho	6020	26	,	,	,
cord-006229-7yoilsho	6020	27	whereas	whereas	IN
cord-006229-7yoilsho	6020	28	AsFAs	AsFAs	NNP
cord-006229-7yoilsho	6020	29	were	be	VBD
cord-006229-7yoilsho	6020	30	less	less	RBR
cord-006229-7yoilsho	6020	31	toxic	toxic	JJ
cord-006229-7yoilsho	6020	32	[	[	-LRB-
cord-006229-7yoilsho	6020	33	3	3	CD
cord-006229-7yoilsho	6020	34	]	]	-RRB-
cord-006229-7yoilsho	6020	35	.	.	.
cord-006229-7yoilsho	6021	1	A	a	DT
cord-006229-7yoilsho	6021	2	substantial	substantial	JJ
cord-006229-7yoilsho	6021	3	transfer	transfer	NN
cord-006229-7yoilsho	6021	4	across	across	IN
cord-006229-7yoilsho	6021	5	an	an	DT
cord-006229-7yoilsho	6021	6	intestinal	intestinal	JJ
cord-006229-7yoilsho	6021	7	barrier	barrier	NN
cord-006229-7yoilsho	6021	8	model	model	NN
cord-006229-7yoilsho	6021	9	(	(	-LRB-
cord-006229-7yoilsho	6021	10	Caco-2	Caco-2	NNP
cord-006229-7yoilsho	6021	11	)	)	-RRB-
cord-006229-7yoilsho	6021	12	indicated	indicate	VBD
cord-006229-7yoilsho	6021	13	that	that	IN
cord-006229-7yoilsho	6021	14	AsHCs	ashcs	PRP
cord-006229-7yoilsho	6021	15	are	be	VBP
cord-006229-7yoilsho	6021	16	highly	highly	RB
cord-006229-7yoilsho	6021	17	intestinal	intestinal	JJ
cord-006229-7yoilsho	6021	18	available	available	JJ
cord-006229-7yoilsho	6021	19	.	.	.
cord-006229-7yoilsho	6022	1	In	in	IN
cord-006229-7yoilsho	6022	2	comparison	comparison	NN
cord-006229-7yoilsho	6022	3	,	,	,
cord-006229-7yoilsho	6022	4	AsFAs	AsFAs	NNP
cord-006229-7yoilsho	6022	5	showed	show	VBD
cord-006229-7yoilsho	6022	6	lower	low	JJR
cord-006229-7yoilsho	6022	7	intestinal	intestinal	JJ
cord-006229-7yoilsho	6022	8	bioavailability	bioavailability	NN
cord-006229-7yoilsho	6022	9	and	and	CC
cord-006229-7yoilsho	6022	10	underwent	undergo	VBD
cord-006229-7yoilsho	6022	11	a	a	DT
cord-006229-7yoilsho	6022	12	presystemic	presystemic	JJ
cord-006229-7yoilsho	6022	13	metabolism	metabolism	NN
cord-006229-7yoilsho	6022	14	[	[	-LRB-
cord-006229-7yoilsho	6022	15	4	4	CD
cord-006229-7yoilsho	6022	16	]	]	-RRB-
cord-006229-7yoilsho	6022	17	.	.	.
cord-006229-7yoilsho	6023	1	Moreover	moreover	RB
cord-006229-7yoilsho	6023	2	,	,	,
cord-006229-7yoilsho	6023	3	in	in	IN
cord-006229-7yoilsho	6023	4	Drosophila	Drosophila	NNP
cord-006229-7yoilsho	6023	5	melanogaster	melanogaster	NN
cord-006229-7yoilsho	6023	6	AsHCs	ashcs	PRP
cord-006229-7yoilsho	6023	7	exerted	exert	VBD
cord-006229-7yoilsho	6023	8	late	late	JJ
cord-006229-7yoilsho	6023	9	developmental	developmental	JJ
cord-006229-7yoilsho	6023	10	toxicity	toxicity	NN
cord-006229-7yoilsho	6023	11	and	and	CC
cord-006229-7yoilsho	6023	12	accumulated	accumulate	VBN
cord-006229-7yoilsho	6023	13	in	in	IN
cord-006229-7yoilsho	6023	14	the	the	DT
cord-006229-7yoilsho	6023	15	fruit	fruit	NN
cord-006229-7yoilsho	6023	16	fly	fly	NN
cord-006229-7yoilsho	6023	17	's	's	POS
cord-006229-7yoilsho	6023	18	brain	brain	NN
cord-006229-7yoilsho	6023	19	.	.	.
cord-006229-7yoilsho	6024	1	These	these	DT
cord-006229-7yoilsho	6024	2	results	result	NNS
cord-006229-7yoilsho	6024	3	suggest	suggest	VBP
cord-006229-7yoilsho	6024	4	that	that	IN
cord-006229-7yoilsho	6024	5	AsHCs	ashcs	PRP
cord-006229-7yoilsho	6024	6	might	may	MD
cord-006229-7yoilsho	6024	7	pass	pass	VB
cord-006229-7yoilsho	6024	8	the	the	DT
cord-006229-7yoilsho	6024	9	blood	blood	NN
cord-006229-7yoilsho	6024	10	-	-	HYPH
cord-006229-7yoilsho	6024	11	brain	brain	NN
cord-006229-7yoilsho	6024	12	-	-	HYPH
cord-006229-7yoilsho	6024	13	barrier	barrier	NN
cord-006229-7yoilsho	6024	14	due	due	IN
cord-006229-7yoilsho	6024	15	to	to	IN
cord-006229-7yoilsho	6024	16	their	-PRON-	PRP$
cord-006229-7yoilsho	6024	17	amphiphilic	amphiphilic	JJ
cord-006229-7yoilsho	6024	18	structure	structure	NN
cord-006229-7yoilsho	6024	19	[	[	-LRB-
cord-006229-7yoilsho	6024	20	5	5	CD
cord-006229-7yoilsho	6024	21	]	]	-RRB-
cord-006229-7yoilsho	6024	22	.	.	.
cord-006229-7yoilsho	6025	1	In	in	IN
cord-006229-7yoilsho	6025	2	order	order	NN
cord-006229-7yoilsho	6025	3	to	to	TO
cord-006229-7yoilsho	6025	4	assess	assess	VB
cord-006229-7yoilsho	6025	5	the	the	DT
cord-006229-7yoilsho	6025	6	neurotoxic	neurotoxic	JJ
cord-006229-7yoilsho	6025	7	potential	potential	NN
cord-006229-7yoilsho	6025	8	we	-PRON-	PRP
cord-006229-7yoilsho	6025	9	currently	currently	RB
cord-006229-7yoilsho	6025	10	investigate	investigate	VBP
cord-006229-7yoilsho	6025	11	the	the	DT
cord-006229-7yoilsho	6025	12	toxicity	toxicity	NN
cord-006229-7yoilsho	6025	13	of	of	IN
cord-006229-7yoilsho	6025	14	several	several	JJ
cord-006229-7yoilsho	6025	15	arsenolipids	arsenolipid	NNS
cord-006229-7yoilsho	6025	16	in	in	IN
cord-006229-7yoilsho	6025	17	differentiated	differentiated	JJ
cord-006229-7yoilsho	6025	18	,	,	,
cord-006229-7yoilsho	6025	19	human	human	JJ
cord-006229-7yoilsho	6025	20	neurons	neuron	NNS
cord-006229-7yoilsho	6025	21	(	(	-LRB-
cord-006229-7yoilsho	6025	22	LUHMES	LUHMES	NNP
cord-006229-7yoilsho	6025	23	)	)	-RRB-
cord-006229-7yoilsho	6025	24	.	.	.
cord-006229-7yoilsho	6026	1	After	after	IN
cord-006229-7yoilsho	6026	2	48	48	CD
cord-006229-7yoilsho	6026	3	h	h	NN
cord-006229-7yoilsho	6026	4	incubation	incubation	NN
cord-006229-7yoilsho	6026	5	with	with	IN
cord-006229-7yoilsho	6026	6	AsHCs	ashcs	PRP
cord-006229-7yoilsho	6026	7	or	or	CC
cord-006229-7yoilsho	6026	8	AsFAs	AsFAs	NNP
cord-006229-7yoilsho	6026	9	,	,	,
cord-006229-7yoilsho	6026	10	cell	cell	NN
cord-006229-7yoilsho	6026	11	number	number	NN
cord-006229-7yoilsho	6026	12	(	(	-LRB-
cord-006229-7yoilsho	6026	13	Hoechst	Hoechst	NNP
cord-006229-7yoilsho	6026	14	)	)	-RRB-
cord-006229-7yoilsho	6026	15	as	as	RB
cord-006229-7yoilsho	6026	16	well	well	RB
cord-006229-7yoilsho	6026	17	as	as	IN
cord-006229-7yoilsho	6026	18	cellular	cellular	JJ
cord-006229-7yoilsho	6026	19	dehydrogenase	dehydrogenase	NN
cord-006229-7yoilsho	6026	20	activity	activity	NN
cord-006229-7yoilsho	6026	21	(	(	-LRB-
cord-006229-7yoilsho	6026	22	Resazurin	Resazurin	NNP
cord-006229-7yoilsho	6026	23	)	)	-RRB-
cord-006229-7yoilsho	6026	24	were	be	VBD
cord-006229-7yoilsho	6026	25	measured	measure	VBN
cord-006229-7yoilsho	6026	26	,	,	,
cord-006229-7yoilsho	6026	27	with	with	IN
cord-006229-7yoilsho	6026	28	the	the	DT
cord-006229-7yoilsho	6026	29	latter	latter	JJ
cord-006229-7yoilsho	6026	30	endpoint	endpoint	NN
cord-006229-7yoilsho	6026	31	turning	turn	VBG
cord-006229-7yoilsho	6026	32	out	out	RP
cord-006229-7yoilsho	6026	33	to	to	TO
cord-006229-7yoilsho	6026	34	be	be	VB
cord-006229-7yoilsho	6026	35	more	more	RBR
cord-006229-7yoilsho	6026	36	sensitive	sensitive	JJ
cord-006229-7yoilsho	6026	37	.	.	.
cord-006229-7yoilsho	6027	1	AsHCs	ashcs	PRP
cord-006229-7yoilsho	6027	2	showed	show	VBD
cord-006229-7yoilsho	6027	3	substantial	substantial	JJ
cord-006229-7yoilsho	6027	4	cytotoxic	cytotoxic	JJ
cord-006229-7yoilsho	6027	5	effects	effect	NNS
cord-006229-7yoilsho	6027	6	(	(	-LRB-
cord-006229-7yoilsho	6027	7	IC	IC	NNP
cord-006229-7yoilsho	6027	8	50	50	CD
cord-006229-7yoilsho	6027	9	~	~	CD
cord-006229-7yoilsho	6027	10	7	7	CD
cord-006229-7yoilsho	6027	11	-	-	SYM
cord-006229-7yoilsho	6027	12	12.5	12.5	CD
cord-006229-7yoilsho	6027	13	µM	µM	NNS
cord-006229-7yoilsho	6027	14	)	)	-RRB-
cord-006229-7yoilsho	6027	15	in	in	IN
cord-006229-7yoilsho	6027	16	a	a	DT
cord-006229-7yoilsho	6027	17	concentration	concentration	NN
cord-006229-7yoilsho	6027	18	range	range	NN
cord-006229-7yoilsho	6027	19	comparable	comparable	JJ
cord-006229-7yoilsho	6027	20	to	to	IN
cord-006229-7yoilsho	6027	21	that	that	DT
cord-006229-7yoilsho	6027	22	of	of	IN
cord-006229-7yoilsho	6027	23	arsenite	arsenite	JJ
cord-006229-7yoilsho	6027	24	(	(	-LRB-
cord-006229-7yoilsho	6027	25	IC	IC	NNP
cord-006229-7yoilsho	6027	26	50	50	CD
cord-006229-7yoilsho	6027	27	~	~	NFP
cord-006229-7yoilsho	6027	28	7.5	7.5	CD
cord-006229-7yoilsho	6027	29	µM	µM	NNPS
cord-006229-7yoilsho	6027	30	)	)	-RRB-
cord-006229-7yoilsho	6027	31	,	,	,
cord-006229-7yoilsho	6027	32	whereas	whereas	IN
cord-006229-7yoilsho	6027	33	AsFAs	AsFAs	NNP
cord-006229-7yoilsho	6027	34	were	be	VBD
cord-006229-7yoilsho	6027	35	less	less	RBR
cord-006229-7yoilsho	6027	36	cytotoxic	cytotoxic	JJ
cord-006229-7yoilsho	6028	1	(	(	-LRB-
cord-006229-7yoilsho	6028	2	IC	IC	NNP
cord-006229-7yoilsho	6028	3	50	50	CD
cord-006229-7yoilsho	6028	4	>	>	SYM
cord-006229-7yoilsho	6028	5	100	100	CD
cord-006229-7yoilsho	6028	6	µM	µm	NN
cord-006229-7yoilsho	6028	7	)	)	-RRB-
cord-006229-7yoilsho	6028	8	.	.	.
cord-006229-7yoilsho	6029	1	After	after	IN
cord-006229-7yoilsho	6029	2	incubation	incubation	NN
cord-006229-7yoilsho	6029	3	with	with	IN
cord-006229-7yoilsho	6029	4	AsHCs	ashcs	PRP
cord-006229-7yoilsho	6029	5	the	the	DT
cord-006229-7yoilsho	6029	6	cellular	cellular	JJ
cord-006229-7yoilsho	6029	7	arsenic	arsenic	NN
cord-006229-7yoilsho	6029	8	concentrations	concentration	NNS
cord-006229-7yoilsho	6029	9	increased	increase	VBD
cord-006229-7yoilsho	6029	10	10	10	CD
cord-006229-7yoilsho	6029	11	-	-	HYPH
cord-006229-7yoilsho	6029	12	20fold	20fold	CD
cord-006229-7yoilsho	6029	13	as	as	IN
cord-006229-7yoilsho	6029	14	compared	compare	VBN
cord-006229-7yoilsho	6029	15	to	to	IN
cord-006229-7yoilsho	6029	16	incubation	incubation	NN
cord-006229-7yoilsho	6029	17	with	with	IN
cord-006229-7yoilsho	6029	18	arsenite	arsenite	NNP
cord-006229-7yoilsho	6029	19	.	.	.
cord-006229-7yoilsho	6030	1	Further	further	JJ
cord-006229-7yoilsho	6030	2	studies	study	NNS
cord-006229-7yoilsho	6030	3	indicated	indicate	VBD
cord-006229-7yoilsho	6030	4	that	that	IN
cord-006229-7yoilsho	6030	5	one	one	CD
cord-006229-7yoilsho	6030	6	possible	possible	JJ
cord-006229-7yoilsho	6030	7	toxic	toxic	JJ
cord-006229-7yoilsho	6030	8	mode	mode	NN
cord-006229-7yoilsho	6030	9	of	of	IN
cord-006229-7yoilsho	6030	10	action	action	NN
cord-006229-7yoilsho	6030	11	of	of	IN
cord-006229-7yoilsho	6030	12	arsenolipids	arsenolipid	NNS
cord-006229-7yoilsho	6030	13	could	could	MD
cord-006229-7yoilsho	6030	14	be	be	VB
cord-006229-7yoilsho	6030	15	a	a	DT
cord-006229-7yoilsho	6030	16	disruption	disruption	NN
cord-006229-7yoilsho	6030	17	of	of	IN
cord-006229-7yoilsho	6030	18	the	the	DT
cord-006229-7yoilsho	6030	19	cellular	cellular	JJ
cord-006229-7yoilsho	6030	20	energy	energy	NN
cord-006229-7yoilsho	6030	21	level	level	NN
cord-006229-7yoilsho	6030	22	.	.	.
cord-006229-7yoilsho	6031	1	Therefore	therefore	RB
cord-006229-7yoilsho	6031	2	,	,	,
cord-006229-7yoilsho	6031	3	the	the	DT
cord-006229-7yoilsho	6031	4	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	6031	5	membrane	membrane	NN
cord-006229-7yoilsho	6031	6	potential	potential	NN
cord-006229-7yoilsho	6031	7	was	be	VBD
cord-006229-7yoilsho	6031	8	investigated	investigate	VBN
cord-006229-7yoilsho	6031	9	after	after	IN
cord-006229-7yoilsho	6031	10	incubation	incubation	NN
cord-006229-7yoilsho	6031	11	with	with	IN
cord-006229-7yoilsho	6031	12	the	the	DT
cord-006229-7yoilsho	6031	13	arsenic	arsenic	NN
cord-006229-7yoilsho	6031	14	compounds	compound	NNS
cord-006229-7yoilsho	6031	15	in	in	IN
cord-006229-7yoilsho	6031	16	differentiated	differentiated	JJ
cord-006229-7yoilsho	6031	17	neurons	neuron	NNS
cord-006229-7yoilsho	6031	18	.	.	.
cord-006229-7yoilsho	6032	1	Whereas	whereas	IN
cord-006229-7yoilsho	6032	2	arsenite	arsenite	NNP
cord-006229-7yoilsho	6032	3	did	do	VBD
cord-006229-7yoilsho	6032	4	not	not	RB
cord-006229-7yoilsho	6032	5	exert	exert	VB
cord-006229-7yoilsho	6032	6	an	an	DT
cord-006229-7yoilsho	6032	7	impact	impact	NN
cord-006229-7yoilsho	6032	8	,	,	,
cord-006229-7yoilsho	6032	9	AsHCs	ashcs	PRP
cord-006229-7yoilsho	6032	10	reduced	reduce	VBD
cord-006229-7yoilsho	6032	11	the	the	DT
cord-006229-7yoilsho	6032	12	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	6032	13	membrane	membrane	NN
cord-006229-7yoilsho	6032	14	potential	potential	NN
cord-006229-7yoilsho	6032	15	significantly	significantly	RB
cord-006229-7yoilsho	6032	16	.	.	.
cord-006229-7yoilsho	6033	1	This	this	DT
cord-006229-7yoilsho	6033	2	might	may	MD
cord-006229-7yoilsho	6033	3	be	be	VB
cord-006229-7yoilsho	6033	4	due	due	JJ
cord-006229-7yoilsho	6033	5	to	to	IN
cord-006229-7yoilsho	6033	6	interactions	interaction	NNS
cord-006229-7yoilsho	6033	7	of	of	IN
cord-006229-7yoilsho	6033	8	the	the	DT
cord-006229-7yoilsho	6033	9	amphiphilic	amphiphilic	JJ
cord-006229-7yoilsho	6033	10	AsHCs	AsHCs	NNP
cord-006229-7yoilsho	6033	11	with	with	IN
cord-006229-7yoilsho	6033	12	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	6033	13	membranes	membrane	NNS
cord-006229-7yoilsho	6033	14	.	.	.
cord-006229-7yoilsho	6034	1	Currently	currently	RB
cord-006229-7yoilsho	6034	2	we	-PRON-	PRP
cord-006229-7yoilsho	6034	3	investigate	investigate	VBP
cord-006229-7yoilsho	6034	4	the	the	DT
cord-006229-7yoilsho	6034	5	impact	impact	NN
cord-006229-7yoilsho	6034	6	of	of	IN
cord-006229-7yoilsho	6034	7	the	the	DT
cord-006229-7yoilsho	6034	8	arsenolipids	arsenolipid	NNS
cord-006229-7yoilsho	6034	9	on	on	IN
cord-006229-7yoilsho	6034	10	neurite	neurite	NN
cord-006229-7yoilsho	6034	11	outgrowth	outgrowth	NN
cord-006229-7yoilsho	6034	12	as	as	IN
cord-006229-7yoilsho	6034	13	a	a	DT
cord-006229-7yoilsho	6034	14	developmental	developmental	JJ
cord-006229-7yoilsho	6034	15	toxicity	toxicity	NN
cord-006229-7yoilsho	6034	16	endpoint	endpoint	NN
cord-006229-7yoilsho	6034	17	.	.	.
cord-006229-7yoilsho	6035	1	Standard	standard	JJ
cord-006229-7yoilsho	6035	2	treatment	treatment	NN
cord-006229-7yoilsho	6035	3	of	of	IN
cord-006229-7yoilsho	6035	4	poisoning	poisoning	NN
cord-006229-7yoilsho	6035	5	by	by	IN
cord-006229-7yoilsho	6035	6	organophosphorus	organophosphorus	JJ
cord-006229-7yoilsho	6035	7	compounds	compound	NNS
cord-006229-7yoilsho	6035	8	(	(	-LRB-
cord-006229-7yoilsho	6035	9	OP	op	NN
cord-006229-7yoilsho	6035	10	;	;	:
cord-006229-7yoilsho	6035	11	e.g.	e.g.	IN
cord-006229-7yoilsho	6035	12	nerve	nerve	NN
cord-006229-7yoilsho	6035	13	agents	agent	NNS
cord-006229-7yoilsho	6035	14	and	and	CC
cord-006229-7yoilsho	6035	15	pesticides	pesticide	NNS
cord-006229-7yoilsho	6035	16	)	)	-RRB-
cord-006229-7yoilsho	6035	17	consists	consist	VBZ
cord-006229-7yoilsho	6035	18	of	of	IN
cord-006229-7yoilsho	6035	19	co	co	NN
cord-006229-7yoilsho	6035	20	-	-	NN
cord-006229-7yoilsho	6035	21	administration	administration	NN
cord-006229-7yoilsho	6035	22	of	of	IN
cord-006229-7yoilsho	6035	23	atropine	atropine	NN
cord-006229-7yoilsho	6035	24	and	and	CC
cord-006229-7yoilsho	6035	25	an	an	DT
cord-006229-7yoilsho	6035	26	oxime	oxime	NN
cord-006229-7yoilsho	6035	27	-	-	HYPH
cord-006229-7yoilsho	6035	28	based	base	VBN
cord-006229-7yoilsho	6035	29	reactivator	reactivator	NN
cord-006229-7yoilsho	6035	30	of	of	IN
cord-006229-7yoilsho	6035	31	inhibited	inhibited	JJ
cord-006229-7yoilsho	6035	32	cholinesterases	cholinesterase	NNS
cord-006229-7yoilsho	6035	33	.	.	.
cord-006229-7yoilsho	6036	1	Due	due	IN
cord-006229-7yoilsho	6036	2	to	to	IN
cord-006229-7yoilsho	6036	3	lack	lack	NN
cord-006229-7yoilsho	6036	4	of	of	IN
cord-006229-7yoilsho	6036	5	efficacy	efficacy	NN
cord-006229-7yoilsho	6036	6	of	of	IN
cord-006229-7yoilsho	6036	7	clinically	clinically	RB
cord-006229-7yoilsho	6036	8	used	use	VBN
cord-006229-7yoilsho	6036	9	oximes	oxime	NNS
cord-006229-7yoilsho	6036	10	against	against	IN
cord-006229-7yoilsho	6036	11	various	various	JJ
cord-006229-7yoilsho	6036	12	OP	op	NN
cord-006229-7yoilsho	6036	13	-	-	HYPH
cord-006229-7yoilsho	6036	14	inhibited	inhibit	VBN
cord-006229-7yoilsho	6036	15	human	human	JJ
cord-006229-7yoilsho	6036	16	acetylcholinesterase	acetylcholinesterase	NN
cord-006229-7yoilsho	6036	17	(	(	-LRB-
cord-006229-7yoilsho	6036	18	AChE	ache	NN
cord-006229-7yoilsho	6036	19	)	)	-RRB-
cord-006229-7yoilsho	6037	1	(	(	-LRB-
cord-006229-7yoilsho	6037	2	e.g.	e.g.	IN
cord-006229-7yoilsho	6037	3	soman	soman	NNP
cord-006229-7yoilsho	6037	4	)	)	-RRB-
cord-006229-7yoilsho	6037	5	research	research	NN
cord-006229-7yoilsho	6037	6	started	start	VBD
cord-006229-7yoilsho	6037	7	focusing	focus	VBG
cord-006229-7yoilsho	6037	8	on	on	IN
cord-006229-7yoilsho	6037	9	new	new	JJ
cord-006229-7yoilsho	6037	10	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	6037	11	approaches	approach	NNS
cord-006229-7yoilsho	6037	12	.	.	.
cord-006229-7yoilsho	6038	1	Several	several	JJ
cord-006229-7yoilsho	6038	2	research	research	NN
cord-006229-7yoilsho	6038	3	groups	group	NNS
cord-006229-7yoilsho	6038	4	conducted	conduct	VBN
cord-006229-7yoilsho	6038	5	in	in	IN
cord-006229-7yoilsho	6038	6	silico	silico	NN
cord-006229-7yoilsho	6038	7	screenings	screening	NNS
cord-006229-7yoilsho	6038	8	[	[	-LRB-
cord-006229-7yoilsho	6038	9	1	1	CD
cord-006229-7yoilsho	6038	10	,	,	,
cord-006229-7yoilsho	6038	11	2	2	CD
cord-006229-7yoilsho	6038	12	]	]	-RRB-
cord-006229-7yoilsho	6038	13	in	in	IN
cord-006229-7yoilsho	6038	14	order	order	NN
cord-006229-7yoilsho	6038	15	to	to	TO
cord-006229-7yoilsho	6038	16	identify	identify	VB
cord-006229-7yoilsho	6038	17	new	new	JJ
cord-006229-7yoilsho	6038	18	non	non	JJ
cord-006229-7yoilsho	6038	19	-	-	JJ
cord-006229-7yoilsho	6038	20	oxime	oxime	JJ
cord-006229-7yoilsho	6038	21	reactivators	reactivator	NNS
cord-006229-7yoilsho	6038	22	,	,	,
cord-006229-7yoilsho	6038	23	presenting	present	VBG
cord-006229-7yoilsho	6038	24	amodiaquine	amodiaquine	NNP
cord-006229-7yoilsho	6038	25	as	as	IN
cord-006229-7yoilsho	6038	26	a	a	DT
cord-006229-7yoilsho	6038	27	promising	promising	JJ
cord-006229-7yoilsho	6038	28	candidate	candidate	NN
cord-006229-7yoilsho	6038	29	for	for	IN
cord-006229-7yoilsho	6038	30	paraoxon	paraoxon	JJ
cord-006229-7yoilsho	6038	31	-	-	HYPH
cord-006229-7yoilsho	6038	32	inhibited	inhibit	VBN
cord-006229-7yoilsho	6038	33	hAChE.	hAChE.	NNP
cord-006229-7yoilsho	6039	1	For	for	IN
cord-006229-7yoilsho	6039	2	decades	decade	NNS
cord-006229-7yoilsho	6039	3	,	,	,
cord-006229-7yoilsho	6039	4	antimalarial	antimalarial	JJ
cord-006229-7yoilsho	6039	5	drugs	drug	NNS
cord-006229-7yoilsho	6039	6	like	like	IN
cord-006229-7yoilsho	6039	7	amodiaquine	amodiaquine	NNP
cord-006229-7yoilsho	6039	8	and	and	CC
cord-006229-7yoilsho	6039	9	chloroquine	chloroquine	NN
cord-006229-7yoilsho	6039	10	have	have	VBP
cord-006229-7yoilsho	6039	11	been	be	VBN
cord-006229-7yoilsho	6039	12	closely	closely	RB
cord-006229-7yoilsho	6039	13	investigated	investigate	VBN
cord-006229-7yoilsho	6039	14	regarding	regard	VBG
cord-006229-7yoilsho	6039	15	their	-PRON-	PRP$
cord-006229-7yoilsho	6039	16	side	side	NN
cord-006229-7yoilsho	6039	17	effects	effect	NNS
cord-006229-7yoilsho	6039	18	,	,	,
cord-006229-7yoilsho	6039	19	thereby	thereby	RB
cord-006229-7yoilsho	6039	20	discovering	discover	VBG
cord-006229-7yoilsho	6039	21	interaction	interaction	NN
cord-006229-7yoilsho	6039	22	with	with	IN
cord-006229-7yoilsho	6039	23	cholinesterases	cholinesterase	NNS
cord-006229-7yoilsho	6039	24	,	,	,
cord-006229-7yoilsho	6039	25	which	which	WDT
cord-006229-7yoilsho	6039	26	could	could	MD
cord-006229-7yoilsho	6039	27	pose	pose	VB
cord-006229-7yoilsho	6039	28	a	a	DT
cord-006229-7yoilsho	6039	29	new	new	JJ
cord-006229-7yoilsho	6039	30	potential	potential	JJ
cord-006229-7yoilsho	6039	31	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	6039	32	benefit	benefit	NN
cord-006229-7yoilsho	6039	33	for	for	IN
cord-006229-7yoilsho	6039	34	inhibited	inhibited	JJ
cord-006229-7yoilsho	6039	35	cholinesterases	cholinesterase	NNS
cord-006229-7yoilsho	6039	36	.	.	.
cord-006229-7yoilsho	6040	1	Therefore	therefore	RB
cord-006229-7yoilsho	6040	2	,	,	,
cord-006229-7yoilsho	6040	3	in	in	IN
cord-006229-7yoilsho	6040	4	this	this	DT
cord-006229-7yoilsho	6040	5	study	study	NN
cord-006229-7yoilsho	6040	6	interactions	interaction	NNS
cord-006229-7yoilsho	6040	7	between	between	IN
cord-006229-7yoilsho	6040	8	antimalarial	antimalarial	JJ
cord-006229-7yoilsho	6040	9	agents	agent	NNS
cord-006229-7yoilsho	6040	10	in	in	IN
cord-006229-7yoilsho	6040	11	presence	presence	NN
cord-006229-7yoilsho	6040	12	or	or	CC
cord-006229-7yoilsho	6040	13	absence	absence	NN
cord-006229-7yoilsho	6040	14	of	of	IN
cord-006229-7yoilsho	6040	15	OPs	op	NNS
cord-006229-7yoilsho	6040	16	were	be	VBD
cord-006229-7yoilsho	6040	17	examined	examine	VBN
cord-006229-7yoilsho	6040	18	spectrophotometrically	spectrophotometrically	RB
cord-006229-7yoilsho	6040	19	by	by	IN
cord-006229-7yoilsho	6040	20	a	a	DT
cord-006229-7yoilsho	6040	21	modified	modify	VBN
cord-006229-7yoilsho	6040	22	Ellman	Ellman	NNP
cord-006229-7yoilsho	6040	23	assay	assay	NN
cord-006229-7yoilsho	6040	24	.	.	.
cord-006229-7yoilsho	6041	1	Reversible	reversible	JJ
cord-006229-7yoilsho	6041	2	inhibition	inhibition	NN
cord-006229-7yoilsho	6041	3	of	of	IN
cord-006229-7yoilsho	6041	4	cholinesterases	cholinesterase	NNS
cord-006229-7yoilsho	6041	5	was	be	VBD
cord-006229-7yoilsho	6041	6	observed	observe	VBN
cord-006229-7yoilsho	6041	7	with	with	IN
cord-006229-7yoilsho	6041	8	both	both	DT
cord-006229-7yoilsho	6041	9	antimalarial	antimalarial	JJ
cord-006229-7yoilsho	6041	10	agents	agent	NNS
cord-006229-7yoilsho	6041	11	.	.	.
cord-006229-7yoilsho	6042	1	Amodiaquine	Amodiaquine	NNP
cord-006229-7yoilsho	6042	2	had	have	VBD
cord-006229-7yoilsho	6042	3	higher	high	JJR
cord-006229-7yoilsho	6042	4	inhibitory	inhibitory	JJ
cord-006229-7yoilsho	6042	5	potency	potency	NN
cord-006229-7yoilsho	6042	6	for	for	IN
cord-006229-7yoilsho	6042	7	hAChE	hache	CD
cord-006229-7yoilsho	6042	8	than	than	IN
cord-006229-7yoilsho	6042	9	human	human	JJ
cord-006229-7yoilsho	6042	10	butyrylcholinesterase	butyrylcholinesterase	NN
cord-006229-7yoilsho	6042	11	(	(	-LRB-
cord-006229-7yoilsho	6042	12	BChE	BChE	NNP
cord-006229-7yoilsho	6042	13	)	)	-RRB-
cord-006229-7yoilsho	6042	14	,	,	,
cord-006229-7yoilsho	6042	15	being	be	VBG
cord-006229-7yoilsho	6042	16	confirmed	confirm	VBN
cord-006229-7yoilsho	6042	17	by	by	IN
cord-006229-7yoilsho	6042	18	IC	IC	NNP
cord-006229-7yoilsho	6042	19	50	50	CD
cord-006229-7yoilsho	6042	20	values	value	NNS
cord-006229-7yoilsho	6042	21	of	of	IN
cord-006229-7yoilsho	6042	22	0.67	0.67	CD
cord-006229-7yoilsho	6042	23	±	±	XX
cord-006229-7yoilsho	6043	1	0.02	0.02	CD
cord-006229-7yoilsho	6043	2	µM	µm	NN
cord-006229-7yoilsho	6043	3	for	for	IN
cord-006229-7yoilsho	6043	4	hAChE	hAChE	NNP
cord-006229-7yoilsho	6043	5	and	and	CC
cord-006229-7yoilsho	6043	6	81.28	81.28	CD
cord-006229-7yoilsho	6043	7	±	±	XX
cord-006229-7yoilsho	6044	1	0.04	0.04	CD
cord-006229-7yoilsho	6044	2	µM	µm	NN
cord-006229-7yoilsho	6044	3	for	for	IN
cord-006229-7yoilsho	6044	4	hBChE.	hbche.	XX
cord-006229-7yoilsho	6044	5	IC	IC	NNP
cord-006229-7yoilsho	6044	6	50	50	CD
cord-006229-7yoilsho	6044	7	values	value	NNS
cord-006229-7yoilsho	6044	8	with	with	IN
cord-006229-7yoilsho	6044	9	chloroquine	chloroquine	NN
cord-006229-7yoilsho	6044	10	were	be	VBD
cord-006229-7yoilsho	6044	11	28.37	28.37	CD
cord-006229-7yoilsho	6044	12	±	±	CD
cord-006229-7yoilsho	6044	13	0.02	0.02	CD
cord-006229-7yoilsho	6044	14	µM	µm	NN
cord-006229-7yoilsho	6044	15	for	for	IN
cord-006229-7yoilsho	6044	16	hAChE	hAChE	NNP
cord-006229-7yoilsho	6044	17	and	and	CC
cord-006229-7yoilsho	6044	18	55.62	55.62	CD
cord-006229-7yoilsho	6044	19	±	±	CD
cord-006229-7yoilsho	6044	20	0.02	0.02	CD
cord-006229-7yoilsho	6044	21	µM	µm	NN
cord-006229-7yoilsho	6044	22	for	for	IN
cord-006229-7yoilsho	6044	23	hBChE	hbche	NN
cord-006229-7yoilsho	6044	24	,	,	,
cord-006229-7yoilsho	6044	25	thus	thus	RB
cord-006229-7yoilsho	6044	26	representing	represent	VBG
cord-006229-7yoilsho	6044	27	a	a	DT
cord-006229-7yoilsho	6044	28	weaker	weak	JJR
cord-006229-7yoilsho	6044	29	inhibition	inhibition	NN
cord-006229-7yoilsho	6044	30	of	of	IN
cord-006229-7yoilsho	6044	31	hAChE	hache	CD
cord-006229-7yoilsho	6044	32	than	than	IN
cord-006229-7yoilsho	6044	33	amodiaquine	amodiaquine	NNP
cord-006229-7yoilsho	6044	34	.	.	.
cord-006229-7yoilsho	6045	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	6045	2	,	,	,
cord-006229-7yoilsho	6045	3	reactivation	reactivation	NN
cord-006229-7yoilsho	6045	4	of	of	IN
cord-006229-7yoilsho	6045	5	paraoxon-(PXE	paraoxon-(PXE	NNP
cord-006229-7yoilsho	6045	6	)	)	-RRB-
cord-006229-7yoilsho	6045	7	,	,	,
cord-006229-7yoilsho	6045	8	sarin-(GB	sarin-(GB	NNP
cord-006229-7yoilsho	6045	9	)	)	-RRB-
cord-006229-7yoilsho	6045	10	,	,	,
cord-006229-7yoilsho	6045	11	cyclosarin-(GF	cyclosarin-(GF	NNP
cord-006229-7yoilsho	6045	12	)	)	-RRB-
cord-006229-7yoilsho	6045	13	,	,	,
cord-006229-7yoilsho	6045	14	and	and	CC
cord-006229-7yoilsho	6045	15	VXinhibited	VXinhibited	NNP
cord-006229-7yoilsho	6045	16	hAChE	hAChE	NNP
cord-006229-7yoilsho	6045	17	and	and	CC
cord-006229-7yoilsho	6045	18	hBChE	hBChE	NNP
cord-006229-7yoilsho	6045	19	by	by	IN
cord-006229-7yoilsho	6045	20	amodiaquine	amodiaquine	NNP
cord-006229-7yoilsho	6045	21	and	and	CC
cord-006229-7yoilsho	6045	22	chloroquine	chloroquine	NN
cord-006229-7yoilsho	6045	23	was	be	VBD
cord-006229-7yoilsho	6045	24	determined	determine	VBN
cord-006229-7yoilsho	6045	25	.	.	.
cord-006229-7yoilsho	6046	1	After	after	IN
cord-006229-7yoilsho	6046	2	60	60	CD
cord-006229-7yoilsho	6046	3	minutes	minute	NNS
cord-006229-7yoilsho	6046	4	,	,	,
cord-006229-7yoilsho	6046	5	only	only	RB
cord-006229-7yoilsho	6046	6	paraoxon	paraoxon	NN
cord-006229-7yoilsho	6046	7	-	-	JJ
cord-006229-7yoilsho	6046	8	inhibited	inhibited	JJ
cord-006229-7yoilsho	6046	9	hAChE	hAChE	NNP
cord-006229-7yoilsho	6046	10	(	(	-LRB-
cord-006229-7yoilsho	6046	11	50	50	CD
cord-006229-7yoilsho	6046	12	%	%	NN
cord-006229-7yoilsho	6046	13	)	)	-RRB-
cord-006229-7yoilsho	6046	14	and	and	CC
cord-006229-7yoilsho	6046	15	cyclosarin	cyclosarin	NN
cord-006229-7yoilsho	6046	16	-	-	HYPH
cord-006229-7yoilsho	6046	17	inhibited	inhibited	JJ
cord-006229-7yoilsho	6046	18	hBChE	hbche	NN
cord-006229-7yoilsho	6046	19	(	(	-LRB-
cord-006229-7yoilsho	6046	20	10	10	CD
cord-006229-7yoilsho	6046	21	%	%	NN
cord-006229-7yoilsho	6046	22	)	)	-RRB-
cord-006229-7yoilsho	6046	23	were	be	VBD
cord-006229-7yoilsho	6046	24	reactivated	reactivate	VBN
cord-006229-7yoilsho	6046	25	by	by	IN
cord-006229-7yoilsho	6046	26	500	500	CD
cord-006229-7yoilsho	6046	27	µM	µm	NN
cord-006229-7yoilsho	6046	28	chloroquine	chloroquine	NN
cord-006229-7yoilsho	6046	29	.	.	.
cord-006229-7yoilsho	6047	1	On	on	IN
cord-006229-7yoilsho	6047	2	the	the	DT
cord-006229-7yoilsho	6047	3	contrary	contrary	NN
cord-006229-7yoilsho	6047	4	,	,	,
cord-006229-7yoilsho	6047	5	10	10	CD
cord-006229-7yoilsho	6047	6	µM	µm	NN
cord-006229-7yoilsho	6047	7	amodiaquine	amodiaquine	NNP
cord-006229-7yoilsho	6047	8	reactivated	reactivate	VBD
cord-006229-7yoilsho	6047	9	all	all	DT
cord-006229-7yoilsho	6047	10	tested	test	VBN
cord-006229-7yoilsho	6047	11	OPs	op	NNS
cord-006229-7yoilsho	6047	12	after	after	IN
cord-006229-7yoilsho	6047	13	60	60	CD
cord-006229-7yoilsho	6047	14	minutes	minute	NNS
cord-006229-7yoilsho	6047	15	in	in	IN
cord-006229-7yoilsho	6047	16	the	the	DT
cord-006229-7yoilsho	6047	17	following	following	JJ
cord-006229-7yoilsho	6047	18	order	order	NN
cord-006229-7yoilsho	6047	19	:	:	:
cord-006229-7yoilsho	6047	20	PXE	PXE	NNP
cord-006229-7yoilsho	6047	21	>	>	XX
cord-006229-7yoilsho	6048	1	VX	VX	NNP
cord-006229-7yoilsho	6048	2	>	>	XX
cord-006229-7yoilsho	6049	1	GF	GF	NNP
cord-006229-7yoilsho	6049	2	>	>	XX
cord-006229-7yoilsho	6050	1	GB	GB	NNP
cord-006229-7yoilsho	6050	2	.	.	.
cord-006229-7yoilsho	6051	1	In	in	IN
cord-006229-7yoilsho	6051	2	contrast	contrast	NN
cord-006229-7yoilsho	6051	3	,	,	,
cord-006229-7yoilsho	6051	4	with	with	IN
cord-006229-7yoilsho	6051	5	hBChE	hbche	ADD
cord-006229-7yoilsho	6051	6	the	the	DT
cord-006229-7yoilsho	6051	7	highest	high	JJS
cord-006229-7yoilsho	6051	8	reactivation	reactivation	NN
cord-006229-7yoilsho	6051	9	was	be	VBD
cord-006229-7yoilsho	6051	10	generated	generate	VBN
cord-006229-7yoilsho	6051	11	with	with	IN
cord-006229-7yoilsho	6051	12	100	100	CD
cord-006229-7yoilsho	6051	13	µM	µm	CD
cord-006229-7yoilsho	6051	14	amodiaquine	amodiaquine	NN
cord-006229-7yoilsho	6051	15	in	in	IN
cord-006229-7yoilsho	6051	16	the	the	DT
cord-006229-7yoilsho	6051	17	following	following	JJ
cord-006229-7yoilsho	6051	18	order	order	NN
cord-006229-7yoilsho	6051	19	:	:	:
cord-006229-7yoilsho	6052	1	VX	VX	NNP
cord-006229-7yoilsho	6052	2	>	>	XX
cord-006229-7yoilsho	6052	3	GB	gb	NN
cord-006229-7yoilsho	6052	4	>	>	XX
cord-006229-7yoilsho	6053	1	GF	GF	NNP
cord-006229-7yoilsho	6053	2	>	>	XX
cord-006229-7yoilsho	6053	3	PXE	PXE	NNP
cord-006229-7yoilsho	6053	4	.	.	.
cord-006229-7yoilsho	6054	1	Due	due	IN
cord-006229-7yoilsho	6054	2	to	to	IN
cord-006229-7yoilsho	6054	3	the	the	DT
cord-006229-7yoilsho	6054	4	high	high	JJ
cord-006229-7yoilsho	6054	5	reversible	reversible	JJ
cord-006229-7yoilsho	6054	6	inhibitory	inhibitory	JJ
cord-006229-7yoilsho	6054	7	potency	potency	NN
cord-006229-7yoilsho	6054	8	of	of	IN
cord-006229-7yoilsho	6054	9	amodiaquine	amodiaquine	NNP
cord-006229-7yoilsho	6054	10	,	,	,
cord-006229-7yoilsho	6054	11	an	an	DT
cord-006229-7yoilsho	6054	12	increased	increase	VBN
cord-006229-7yoilsho	6054	13	concentration	concentration	NN
cord-006229-7yoilsho	6054	14	does	do	VBZ
cord-006229-7yoilsho	6054	15	not	not	RB
cord-006229-7yoilsho	6054	16	result	result	VB
cord-006229-7yoilsho	6054	17	in	in	IN
cord-006229-7yoilsho	6054	18	a	a	DT
cord-006229-7yoilsho	6054	19	higher	high	JJR
cord-006229-7yoilsho	6054	20	reactivation	reactivation	NN
cord-006229-7yoilsho	6054	21	of	of	IN
cord-006229-7yoilsho	6054	22	OP	op	NN
cord-006229-7yoilsho	6054	23	-	-	HYPH
cord-006229-7yoilsho	6054	24	inhibited	inhibit	VBN
cord-006229-7yoilsho	6054	25	hAChE.	hAChE.	NNP
cord-006229-7yoilsho	6055	1	In	in	IN
cord-006229-7yoilsho	6055	2	summary	summary	NN
cord-006229-7yoilsho	6055	3	,	,	,
cord-006229-7yoilsho	6055	4	our	-PRON-	PRP$
cord-006229-7yoilsho	6055	5	results	result	NNS
cord-006229-7yoilsho	6055	6	show	show	VBP
cord-006229-7yoilsho	6055	7	that	that	IN
cord-006229-7yoilsho	6055	8	amodiaquine	amodiaquine	NNP
cord-006229-7yoilsho	6055	9	is	be	VBZ
cord-006229-7yoilsho	6055	10	a	a	DT
cord-006229-7yoilsho	6055	11	reactivator	reactivator	NN
cord-006229-7yoilsho	6055	12	of	of	IN
cord-006229-7yoilsho	6055	13	OP	OP	NNP
cord-006229-7yoilsho	6055	14	-	-	HYPH
cord-006229-7yoilsho	6055	15	inhibited	inhibit	VBN
cord-006229-7yoilsho	6055	16	cholinesterases	cholinesterase	NNS
cord-006229-7yoilsho	6055	17	.	.	.
cord-006229-7yoilsho	6056	1	In	in	IN
cord-006229-7yoilsho	6056	2	the	the	DT
cord-006229-7yoilsho	6056	3	future	future	NN
cord-006229-7yoilsho	6056	4	,	,	,
cord-006229-7yoilsho	6056	5	non	non	JJ
cord-006229-7yoilsho	6056	6	-	-	JJ
cord-006229-7yoilsho	6056	7	oxime	oxime	JJ
cord-006229-7yoilsho	6056	8	reactivators	reactivator	NNS
cord-006229-7yoilsho	6056	9	that	that	WDT
cord-006229-7yoilsho	6056	10	are	be	VBP
cord-006229-7yoilsho	6056	11	structurally	structurally	RB
cord-006229-7yoilsho	6056	12	-	-	HYPH
cord-006229-7yoilsho	6056	13	related	relate	VBN
cord-006229-7yoilsho	6056	14	to	to	IN
cord-006229-7yoilsho	6056	15	amodiaquine	amodiaquine	NNP
cord-006229-7yoilsho	6056	16	should	should	MD
cord-006229-7yoilsho	6056	17	be	be	VB
cord-006229-7yoilsho	6056	18	further	further	RB
cord-006229-7yoilsho	6056	19	investigated	investigate	VBN
cord-006229-7yoilsho	6056	20	.	.	.
cord-006229-7yoilsho	6057	1	[	[	-LRB-
cord-006229-7yoilsho	6057	2	1	1	LS
cord-006229-7yoilsho	6057	3	]	]	-RRB-
cord-006229-7yoilsho	6057	4	Bhattacharjee	Bhattacharjee	NNP
cord-006229-7yoilsho	6057	5	,	,	,
cord-006229-7yoilsho	6057	6	A.K.	A.K.	NNP
cord-006229-7yoilsho	6057	7	,	,	,
cord-006229-7yoilsho	6057	8	Marek	Marek	NNP
cord-006229-7yoilsho	6057	9	,	,	,
cord-006229-7yoilsho	6057	10	E.	E.	NNP
cord-006229-7yoilsho	6057	11	,	,	,
cord-006229-7yoilsho	6057	12	Le	Le	NNP
cord-006229-7yoilsho	6057	13	,	,	,
cord-006229-7yoilsho	6057	14	H.T.	H.T.	NNP
cord-006229-7yoilsho	6057	15	,	,	,
cord-006229-7yoilsho	6057	16	Gordon	Gordon	NNP
cord-006229-7yoilsho	6057	17	,	,	,
cord-006229-7yoilsho	6057	18	R.K.	R.K.	NNP
cord-006229-7yoilsho	6057	19	,	,	,
cord-006229-7yoilsho	6057	20	Eur	Eur	NNP
cord-006229-7yoilsho	6057	21	.	.	.
cord-006229-7yoilsho	6058	1	J.	J.	NNP
cord-006229-7yoilsho	6058	2	Med	Med	NNP
cord-006229-7yoilsho	6058	3	.	.	.
cord-006229-7yoilsho	6058	4	Chem	Chem	NNP
cord-006229-7yoilsho	6058	5	.	.	.
cord-006229-7yoilsho	6059	1	,	,	,
cord-006229-7yoilsho	6059	2	2012	2012	CD
cord-006229-7yoilsho	6059	3	,	,	,
cord-006229-7yoilsho	6059	4	49	49	CD
cord-006229-7yoilsho	6059	5	,	,	,
cord-006229-7yoilsho	6059	6	229	229	CD
cord-006229-7yoilsho	6059	7	-	-	SYM
cord-006229-7yoilsho	6059	8	238	238	CD
cord-006229-7yoilsho	6059	9	.	.	.
cord-006229-7yoilsho	6060	1	[	[	-LRB-
cord-006229-7yoilsho	6060	2	2	2	CD
cord-006229-7yoilsho	6060	3	]	]	-RRB-
cord-006229-7yoilsho	6060	4	Katz	Katz	NNP
cord-006229-7yoilsho	6060	5	,	,	,
cord-006229-7yoilsho	6060	6	F.S.	F.S.	NNP
cord-006229-7yoilsho	6060	7	,	,	,
cord-006229-7yoilsho	6060	8	Pecic	Pecic	NNP
cord-006229-7yoilsho	6060	9	,	,	,
cord-006229-7yoilsho	6060	10	S.	S.	NNP
cord-006229-7yoilsho	6060	11	,	,	,
cord-006229-7yoilsho	6060	12	Tran	Tran	NNP
cord-006229-7yoilsho	6060	13	,	,	,
cord-006229-7yoilsho	6060	14	T.H.	T.H.	NNP
cord-006229-7yoilsho	6060	15	,	,	,
cord-006229-7yoilsho	6060	16	Trakht	Trakht	NNP
cord-006229-7yoilsho	6060	17	,	,	,
cord-006229-7yoilsho	6060	18	I.	I.	NNP
cord-006229-7yoilsho	6060	19	,	,	,
cord-006229-7yoilsho	6060	20	Schneider	Schneider	NNP
cord-006229-7yoilsho	6060	21	,	,	,
cord-006229-7yoilsho	6060	22	L.	L.	NNP
cord-006229-7yoilsho	6060	23	,	,	,
cord-006229-7yoilsho	6060	24	Zhu	Zhu	NNP
cord-006229-7yoilsho	6060	25	,	,	,
cord-006229-7yoilsho	6060	26	Z.	Z.	NNP
cord-006229-7yoilsho	6060	27	,	,	,
cord-006229-7yoilsho	6060	28	Ton	Ton	NNP
cord-006229-7yoilsho	6060	29	-	-	:
cord-006229-7yoilsho	6060	30	That	that	IN
cord-006229-7yoilsho	6060	31	,	,	,
cord-006229-7yoilsho	6060	32	L.	L.	NNP
cord-006229-7yoilsho	6060	33	,	,	,
cord-006229-7yoilsho	6060	34	Luzac	Luzac	NNP
cord-006229-7yoilsho	6060	35	,	,	,
cord-006229-7yoilsho	6060	36	M.	M.	NNP
cord-006229-7yoilsho	6060	37	,	,	,
cord-006229-7yoilsho	6060	38	Zlatanic	Zlatanic	NNP
cord-006229-7yoilsho	6060	39	,	,	,
cord-006229-7yoilsho	6060	40	V.	V.	NNP
cord-006229-7yoilsho	6060	41	,	,	,
cord-006229-7yoilsho	6060	42	Damera	Damera	NNP
cord-006229-7yoilsho	6060	43	,	,	,
cord-006229-7yoilsho	6060	44	S.	S.	NNP
cord-006229-7yoilsho	6060	45	,	,	,
cord-006229-7yoilsho	6060	46	Macdonald	Macdonald	NNP
cord-006229-7yoilsho	6060	47	,	,	,
cord-006229-7yoilsho	6060	48	J.	J.	NNP
cord-006229-7yoilsho	6060	49	,	,	,
cord-006229-7yoilsho	6060	50	Landry	Landry	NNP
cord-006229-7yoilsho	6060	51	,	,	,
cord-006229-7yoilsho	6060	52	D.W.	D.W.	NNP
cord-006229-7yoilsho	6060	53	,	,	,
cord-006229-7yoilsho	6060	54	Tong	Tong	NNP
cord-006229-7yoilsho	6060	55	,	,	,
cord-006229-7yoilsho	6060	56	L.	L.	NNP
cord-006229-7yoilsho	6060	57	,	,	,
cord-006229-7yoilsho	6060	58	Stojanovic	Stojanovic	NNP
cord-006229-7yoilsho	6060	59	,	,	,
cord-006229-7yoilsho	6060	60	M.N.	M.N.	NNP
cord-006229-7yoilsho	6060	61	,	,	,
cord-006229-7yoilsho	6060	62	Chembiochem	Chembiochem	NNP
cord-006229-7yoilsho	6060	63	.	.	.
cord-006229-7yoilsho	6060	64	,	,	,
cord-006229-7yoilsho	6060	65	2015	2015	CD
cord-006229-7yoilsho	6060	66	,	,	,
cord-006229-7yoilsho	6060	67	16	16	CD
cord-006229-7yoilsho	6060	68	,	,	,
cord-006229-7yoilsho	6060	69	2205	2205	CD
cord-006229-7yoilsho	6061	1	-2215	-2215	:
cord-006229-7yoilsho	6061	2	Bundesinstitut	Bundesinstitut	NNP
cord-006229-7yoilsho	6061	3	für	für	NNP
cord-006229-7yoilsho	6061	4	Risikobewertung	Risikobewertung	NNP
cord-006229-7yoilsho	6061	5	,	,	,
cord-006229-7yoilsho	6061	6	Lebensmittelsicherheit	Lebensmittelsicherheit	NNP
cord-006229-7yoilsho	6061	7	,	,	,
cord-006229-7yoilsho	6061	8	Berlin	Berlin	NNP
cord-006229-7yoilsho	6061	9	,	,	,
cord-006229-7yoilsho	6061	10	Germany	Germany	NNP
cord-006229-7yoilsho	6061	11	Development	Development	NNP
cord-006229-7yoilsho	6061	12	of	of	IN
cord-006229-7yoilsho	6061	13	mammary	mammary	JJ
cord-006229-7yoilsho	6061	14	gland	gland	NN
cord-006229-7yoilsho	6061	15	tumors	tumor	NNS
cord-006229-7yoilsho	6061	16	is	be	VBZ
cord-006229-7yoilsho	6061	17	connected	connect	VBN
cord-006229-7yoilsho	6061	18	to	to	IN
cord-006229-7yoilsho	6061	19	a	a	DT
cord-006229-7yoilsho	6061	20	deregulation	deregulation	NN
cord-006229-7yoilsho	6061	21	of	of	IN
cord-006229-7yoilsho	6061	22	breast	breast	NN
cord-006229-7yoilsho	6061	23	epithelial	epithelial	JJ
cord-006229-7yoilsho	6061	24	cell	cell	NN
cord-006229-7yoilsho	6061	25	differentiation	differentiation	NN
cord-006229-7yoilsho	6061	26	,	,	,
cord-006229-7yoilsho	6061	27	a	a	DT
cord-006229-7yoilsho	6061	28	complex	complex	JJ
cord-006229-7yoilsho	6061	29	process	process	NN
cord-006229-7yoilsho	6061	30	which	which	WDT
cord-006229-7yoilsho	6061	31	can	can	MD
cord-006229-7yoilsho	6061	32	not	not	RB
cord-006229-7yoilsho	6061	33	be	be	VB
cord-006229-7yoilsho	6061	34	reproduced	reproduce	VBN
cord-006229-7yoilsho	6061	35	in	in	IN
cord-006229-7yoilsho	6061	36	vitro	vitro	FW
cord-006229-7yoilsho	6061	37	under	under	IN
cord-006229-7yoilsho	6061	38	standard	standard	JJ
cord-006229-7yoilsho	6061	39	cell	cell	NN
cord-006229-7yoilsho	6061	40	culture	culture	NN
cord-006229-7yoilsho	6061	41	conditions	condition	NNS
cord-006229-7yoilsho	6061	42	.	.	.
cord-006229-7yoilsho	6062	1	However	however	RB
cord-006229-7yoilsho	6062	2	,	,	,
cord-006229-7yoilsho	6062	3	cultivation	cultivation	NN
cord-006229-7yoilsho	6062	4	of	of	IN
cord-006229-7yoilsho	6062	5	cells	cell	NNS
cord-006229-7yoilsho	6062	6	in	in	IN
cord-006229-7yoilsho	6062	7	a	a	DT
cord-006229-7yoilsho	6062	8	tissue	tissue	NN
cord-006229-7yoilsho	6062	9	-	-	HYPH
cord-006229-7yoilsho	6062	10	like	like	JJ
cord-006229-7yoilsho	6062	11	environment	environment	NN
cord-006229-7yoilsho	6062	12	in	in	IN
cord-006229-7yoilsho	6062	13	an	an	DT
cord-006229-7yoilsho	6062	14	in	in	FW
cord-006229-7yoilsho	6062	15	vitro	vitro	FW
cord-006229-7yoilsho	6062	16	three	three	CD
cord-006229-7yoilsho	6062	17	dimensional	dimensional	JJ
cord-006229-7yoilsho	6062	18	(	(	-LRB-
cord-006229-7yoilsho	6062	19	3D	3D	NNP
cord-006229-7yoilsho	6062	20	)	)	-RRB-
cord-006229-7yoilsho	6062	21	model	model	NN
cord-006229-7yoilsho	6062	22	can	can	MD
cord-006229-7yoilsho	6062	23	mimic	mimic	VB
cord-006229-7yoilsho	6062	24	general	general	JJ
cord-006229-7yoilsho	6062	25	architecture	architecture	NN
cord-006229-7yoilsho	6062	26	,	,	,
cord-006229-7yoilsho	6062	27	function	function	NN
cord-006229-7yoilsho	6062	28	and	and	CC
cord-006229-7yoilsho	6062	29	differentiation	differentiation	NN
cord-006229-7yoilsho	6062	30	of	of	IN
cord-006229-7yoilsho	6062	31	mammary	mammary	JJ
cord-006229-7yoilsho	6062	32	bulks	bulk	NNS
cord-006229-7yoilsho	6062	33	.	.	.
cord-006229-7yoilsho	6063	1	In	in	IN
cord-006229-7yoilsho	6063	2	this	this	DT
cord-006229-7yoilsho	6063	3	project	project	NN
cord-006229-7yoilsho	6063	4	,	,	,
cord-006229-7yoilsho	6063	5	a	a	DT
cord-006229-7yoilsho	6063	6	3D	3d	JJ
cord-006229-7yoilsho	6063	7	model	model	NN
cord-006229-7yoilsho	6063	8	was	be	VBD
cord-006229-7yoilsho	6063	9	used	use	VBN
cord-006229-7yoilsho	6063	10	consisting	consist	VBG
cord-006229-7yoilsho	6063	11	of	of	IN
cord-006229-7yoilsho	6063	12	the	the	DT
cord-006229-7yoilsho	6063	13	permanent	permanent	JJ
cord-006229-7yoilsho	6063	14	breast	breast	NN
cord-006229-7yoilsho	6063	15	epithelial	epithelial	JJ
cord-006229-7yoilsho	6063	16	cell	cell	NN
cord-006229-7yoilsho	6063	17	lines	line	NNS
cord-006229-7yoilsho	6063	18	MCF10A	mcf10a	JJ
cord-006229-7yoilsho	6064	1	(	(	-LRB-
cord-006229-7yoilsho	6064	2	ER	ER	NNP
cord-006229-7yoilsho	6064	3	-	-	HYPH
cord-006229-7yoilsho	6064	4	,	,	,
cord-006229-7yoilsho	6064	5	estrogen	estrogen	NN
cord-006229-7yoilsho	6064	6	receptor	receptor	NN
cord-006229-7yoilsho	6064	7	negative	negative	NN
cord-006229-7yoilsho	6064	8	)	)	-RRB-
cord-006229-7yoilsho	6064	9	and	and	CC
cord-006229-7yoilsho	6064	10	MCF12A	mcf12a	NN
cord-006229-7yoilsho	6065	1	(	(	-LRB-
cord-006229-7yoilsho	6065	2	ER	ER	NNP
cord-006229-7yoilsho	6065	3	+	+	CC
cord-006229-7yoilsho	6065	4	,	,	,
cord-006229-7yoilsho	6065	5	estrogen	estrogen	NN
cord-006229-7yoilsho	6065	6	receptor	receptor	NN
cord-006229-7yoilsho	6065	7	negative	negative	NN
cord-006229-7yoilsho	6065	8	)	)	-RRB-
cord-006229-7yoilsho	6065	9	grown	grow	VBN
cord-006229-7yoilsho	6065	10	in	in	IN
cord-006229-7yoilsho	6065	11	Matrigel	Matrigel	NNP
cord-006229-7yoilsho	6065	12	TM	TM	NNP
cord-006229-7yoilsho	6065	13	,	,	,
cord-006229-7yoilsho	6065	14	which	which	WDT
cord-006229-7yoilsho	6065	15	mimics	mimic	VBZ
cord-006229-7yoilsho	6065	16	the	the	DT
cord-006229-7yoilsho	6065	17	complex	complex	JJ
cord-006229-7yoilsho	6065	18	extracellular	extracellular	JJ
cord-006229-7yoilsho	6065	19	matrix	matrix	NN
cord-006229-7yoilsho	6065	20	in	in	IN
cord-006229-7yoilsho	6065	21	vivo	vivo	NNP
cord-006229-7yoilsho	6065	22	.	.	.
cord-006229-7yoilsho	6066	1	The	the	DT
cord-006229-7yoilsho	6066	2	3D	3d	JJ
cord-006229-7yoilsho	6066	3	culture	culture	NN
cord-006229-7yoilsho	6066	4	of	of	IN
cord-006229-7yoilsho	6066	5	MCF10A	MCF10A	NNP
cord-006229-7yoilsho	6066	6	and	and	CC
cord-006229-7yoilsho	6066	7	MCF12A	mcf12a	NN
cord-006229-7yoilsho	6066	8	cells	cell	NNS
cord-006229-7yoilsho	6066	9	in	in	IN
cord-006229-7yoilsho	6066	10	Matrigel	Matrigel	NNP
cord-006229-7yoilsho	6066	11	TM	TM	NNP
cord-006229-7yoilsho	6066	12	results	result	NNS
cord-006229-7yoilsho	6066	13	in	in	IN
cord-006229-7yoilsho	6066	14	the	the	DT
cord-006229-7yoilsho	6066	15	formation	formation	NN
cord-006229-7yoilsho	6066	16	of	of	IN
cord-006229-7yoilsho	6066	17	growth	growth	NN
cord-006229-7yoilsho	6066	18	-	-	HYPH
cord-006229-7yoilsho	6066	19	arrested	arrest	VBN
cord-006229-7yoilsho	6066	20	,	,	,
cord-006229-7yoilsho	6066	21	polarized	polarized	JJ
cord-006229-7yoilsho	6066	22	spheroids	spheroid	NNS
cord-006229-7yoilsho	6066	23	with	with	IN
cord-006229-7yoilsho	6066	24	a	a	DT
cord-006229-7yoilsho	6066	25	lumen	lumen	NN
cord-006229-7yoilsho	6066	26	(	(	-LRB-
cord-006229-7yoilsho	6066	27	acini	acini	NNP
cord-006229-7yoilsho	6066	28	-	-	HYPH
cord-006229-7yoilsho	6066	29	like	like	JJ
cord-006229-7yoilsho	6066	30	organoids	organoids	NNP
cord-006229-7yoilsho	6066	31	)	)	-RRB-
cord-006229-7yoilsho	6066	32	.	.	.
cord-006229-7yoilsho	6067	1	In	in	IN
cord-006229-7yoilsho	6067	2	order	order	NN
cord-006229-7yoilsho	6067	3	to	to	TO
cord-006229-7yoilsho	6067	4	perform	perform	VB
cord-006229-7yoilsho	6067	5	a	a	DT
cord-006229-7yoilsho	6067	6	semi	semi	JJ
cord-006229-7yoilsho	6067	7	-	-	JJ
cord-006229-7yoilsho	6067	8	quantitative	quantitative	JJ
cord-006229-7yoilsho	6067	9	estimation	estimation	NN
cord-006229-7yoilsho	6067	10	on	on	IN
cord-006229-7yoilsho	6067	11	the	the	DT
cord-006229-7yoilsho	6067	12	influence	influence	NN
cord-006229-7yoilsho	6067	13	of	of	IN
cord-006229-7yoilsho	6067	14	substances	substance	NNS
cord-006229-7yoilsho	6067	15	on	on	IN
cord-006229-7yoilsho	6067	16	the	the	DT
cord-006229-7yoilsho	6067	17	differentiation	differentiation	NN
cord-006229-7yoilsho	6067	18	of	of	IN
cord-006229-7yoilsho	6067	19	the	the	DT
cord-006229-7yoilsho	6067	20	breast	breast	NN
cord-006229-7yoilsho	6067	21	cells	cell	NNS
cord-006229-7yoilsho	6067	22	for	for	IN
cord-006229-7yoilsho	6067	23	the	the	DT
cord-006229-7yoilsho	6067	24	identification	identification	NN
cord-006229-7yoilsho	6067	25	of	of	IN
cord-006229-7yoilsho	6067	26	non	non	JJ
cord-006229-7yoilsho	6067	27	-	-	JJ
cord-006229-7yoilsho	6067	28	genotoxic	genotoxic	JJ
cord-006229-7yoilsho	6067	29	carcinogens	carcinogen	NNS
cord-006229-7yoilsho	6067	30	a	a	DT
cord-006229-7yoilsho	6067	31	scoring	scoring	NN
cord-006229-7yoilsho	6067	32	method	method	NN
cord-006229-7yoilsho	6067	33	was	be	VBD
cord-006229-7yoilsho	6067	34	developed	develop	VBN
cord-006229-7yoilsho	6067	35	.	.	.
cord-006229-7yoilsho	6068	1	This	this	DT
cord-006229-7yoilsho	6068	2	scoring	scoring	NN
cord-006229-7yoilsho	6068	3	method	method	NN
cord-006229-7yoilsho	6068	4	provides	provide	VBZ
cord-006229-7yoilsho	6068	5	information	information	NN
cord-006229-7yoilsho	6068	6	about	about	IN
cord-006229-7yoilsho	6068	7	substance	substance	NN
cord-006229-7yoilsho	6068	8	-	-	HYPH
cord-006229-7yoilsho	6068	9	induced	induce	VBN
cord-006229-7yoilsho	6068	10	morphological	morphological	JJ
cord-006229-7yoilsho	6068	11	changes	change	NNS
cord-006229-7yoilsho	6068	12	of	of	IN
cord-006229-7yoilsho	6068	13	the	the	DT
cord-006229-7yoilsho	6068	14	spheroids	spheroid	NNS
cord-006229-7yoilsho	6068	15	during	during	IN
cord-006229-7yoilsho	6068	16	differentiation	differentiation	NN
cord-006229-7yoilsho	6068	17	based	base	VBN
cord-006229-7yoilsho	6068	18	on	on	IN
cord-006229-7yoilsho	6068	19	the	the	DT
cord-006229-7yoilsho	6068	20	following	follow	VBG
cord-006229-7yoilsho	6068	21	parameters	parameter	NNS
cord-006229-7yoilsho	6068	22	:	:	:
cord-006229-7yoilsho	6068	23	size	size	NN
cord-006229-7yoilsho	6068	24	of	of	IN
cord-006229-7yoilsho	6068	25	the	the	DT
cord-006229-7yoilsho	6068	26	spheroids	spheroid	NNS
cord-006229-7yoilsho	6068	27	,	,	,
cord-006229-7yoilsho	6068	28	the	the	DT
cord-006229-7yoilsho	6068	29	formation	formation	NN
cord-006229-7yoilsho	6068	30	of	of	IN
cord-006229-7yoilsho	6068	31	the	the	DT
cord-006229-7yoilsho	6068	32	lumen	lumen	NN
cord-006229-7yoilsho	6068	33	,	,	,
cord-006229-7yoilsho	6068	34	and	and	CC
cord-006229-7yoilsho	6068	35	the	the	DT
cord-006229-7yoilsho	6068	36	degree	degree	NN
cord-006229-7yoilsho	6068	37	of	of	IN
cord-006229-7yoilsho	6068	38	polarization	polarization	NN
cord-006229-7yoilsho	6068	39	.	.	.
cord-006229-7yoilsho	6069	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	6069	2	,	,	,
cord-006229-7yoilsho	6069	3	the	the	DT
cord-006229-7yoilsho	6069	4	model	model	NN
cord-006229-7yoilsho	6069	5	allows	allow	VBZ
cord-006229-7yoilsho	6069	6	distinguishing	distinguish	VBG
cord-006229-7yoilsho	6069	7	between	between	IN
cord-006229-7yoilsho	6069	8	ERdependent	ERdependent	NNP
cord-006229-7yoilsho	6069	9	(	(	-LRB-
cord-006229-7yoilsho	6069	10	MCF12A	mcf12a	NN
cord-006229-7yoilsho	6069	11	)	)	-RRB-
cord-006229-7yoilsho	6069	12	and	and	CC
cord-006229-7yoilsho	6069	13	ER	ER	NNP
cord-006229-7yoilsho	6069	14	-	-	HYPH
cord-006229-7yoilsho	6069	15	independent	independent	JJ
cord-006229-7yoilsho	6069	16	(	(	-LRB-
cord-006229-7yoilsho	6069	17	MCF10A	MCF10A	NNP
cord-006229-7yoilsho	6069	18	and	and	CC
cord-006229-7yoilsho	6069	19	MCF12A	mcf12a	NN
cord-006229-7yoilsho	6069	20	)	)	-RRB-
cord-006229-7yoilsho	6069	21	effects	effect	NNS
cord-006229-7yoilsho	6069	22	.	.	.
cord-006229-7yoilsho	6070	1	The	the	DT
cord-006229-7yoilsho	6070	2	3D	3d	NN
cord-006229-7yoilsho	6070	3	in	in	IN
cord-006229-7yoilsho	6070	4	vitro	vitro	FW
cord-006229-7yoilsho	6070	5	model	model	NN
cord-006229-7yoilsho	6070	6	is	be	VBZ
cord-006229-7yoilsho	6070	7	a	a	DT
cord-006229-7yoilsho	6070	8	useful	useful	JJ
cord-006229-7yoilsho	6070	9	tool	tool	NN
cord-006229-7yoilsho	6070	10	for	for	IN
cord-006229-7yoilsho	6070	11	toxicologists	toxicologist	NNS
cord-006229-7yoilsho	6070	12	to	to	TO
cord-006229-7yoilsho	6070	13	study	study	VB
cord-006229-7yoilsho	6070	14	substance	substance	NN
cord-006229-7yoilsho	6070	15	effects	effect	NNS
cord-006229-7yoilsho	6070	16	on	on	IN
cord-006229-7yoilsho	6070	17	differentiation	differentiation	NN
cord-006229-7yoilsho	6070	18	processes	process	NNS
cord-006229-7yoilsho	6070	19	.	.	.
cord-006229-7yoilsho	6071	1	The	the	DT
cord-006229-7yoilsho	6071	2	system	system	NN
cord-006229-7yoilsho	6071	3	will	will	MD
cord-006229-7yoilsho	6071	4	be	be	VB
cord-006229-7yoilsho	6071	5	used	use	VBN
cord-006229-7yoilsho	6071	6	to	to	TO
cord-006229-7yoilsho	6071	7	examine	examine	VB
cord-006229-7yoilsho	6071	8	the	the	DT
cord-006229-7yoilsho	6071	9	potential	potential	NN
cord-006229-7yoilsho	6071	10	of	of	IN
cord-006229-7yoilsho	6071	11	e.g.	e.g.	JJ
cord-006229-7yoilsho	6071	12	food	food	NN
cord-006229-7yoilsho	6071	13	contaminants	contaminant	NNS
cord-006229-7yoilsho	6071	14	such	such	JJ
cord-006229-7yoilsho	6071	15	as	as	IN
cord-006229-7yoilsho	6071	16	phthalates	phthalate	NNS
cord-006229-7yoilsho	6071	17	or	or	CC
cord-006229-7yoilsho	6071	18	perfluorinated	perfluorinate	VBN
cord-006229-7yoilsho	6071	19	substances	substance	NNS
cord-006229-7yoilsho	6071	20	(	(	-LRB-
cord-006229-7yoilsho	6071	21	PFAS	PFAS	NNP
cord-006229-7yoilsho	6071	22	)	)	-RRB-
cord-006229-7yoilsho	6071	23	to	to	TO
cord-006229-7yoilsho	6071	24	disrupt	disrupt	VB
cord-006229-7yoilsho	6071	25	the	the	DT
cord-006229-7yoilsho	6071	26	differentiation	differentiation	NN
cord-006229-7yoilsho	6071	27	process	process	NN
cord-006229-7yoilsho	6071	28	of	of	IN
cord-006229-7yoilsho	6071	29	breast	breast	NN
cord-006229-7yoilsho	6071	30	epithelial	epithelial	JJ
cord-006229-7yoilsho	6071	31	cells	cell	NNS
cord-006229-7yoilsho	6071	32	and	and	CC
cord-006229-7yoilsho	6071	33	will	will	MD
cord-006229-7yoilsho	6071	34	therefore	therefore	RB
cord-006229-7yoilsho	6071	35	serve	serve	VB
cord-006229-7yoilsho	6071	36	as	as	IN
cord-006229-7yoilsho	6071	37	a	a	DT
cord-006229-7yoilsho	6071	38	valuable	valuable	JJ
cord-006229-7yoilsho	6071	39	in	in	FW
cord-006229-7yoilsho	6071	40	vitro	vitro	FW
cord-006229-7yoilsho	6071	41	tool	tool	NN
cord-006229-7yoilsho	6071	42	to	to	TO
cord-006229-7yoilsho	6071	43	assess	assess	VB
cord-006229-7yoilsho	6071	44	their	-PRON-	PRP$
cord-006229-7yoilsho	6071	45	carcinogenic	carcinogenic	JJ
cord-006229-7yoilsho	6071	46	potential	potential	NN
cord-006229-7yoilsho	6071	47	.	.	.
cord-006229-7yoilsho	6072	1	Inflammatory	inflammatory	JJ
cord-006229-7yoilsho	6072	2	episodes	episode	NNS
cord-006229-7yoilsho	6072	3	occur	occur	VBP
cord-006229-7yoilsho	6072	4	erratically	erratically	RB
cord-006229-7yoilsho	6072	5	throughout	throughout	IN
cord-006229-7yoilsho	6072	6	life	life	NN
cord-006229-7yoilsho	6072	7	and	and	CC
cord-006229-7yoilsho	6072	8	are	be	VBP
cord-006229-7yoilsho	6072	9	likely	likely	JJ
cord-006229-7yoilsho	6072	10	to	to	TO
cord-006229-7yoilsho	6072	11	play	play	VB
cord-006229-7yoilsho	6072	12	a	a	DT
cord-006229-7yoilsho	6072	13	critical	critical	JJ
cord-006229-7yoilsho	6072	14	role	role	NN
cord-006229-7yoilsho	6072	15	in	in	IN
cord-006229-7yoilsho	6072	16	the	the	DT
cord-006229-7yoilsho	6072	17	alteration	alteration	NN
cord-006229-7yoilsho	6072	18	of	of	IN
cord-006229-7yoilsho	6072	19	the	the	DT
cord-006229-7yoilsho	6072	20	individual	individual	JJ
cord-006229-7yoilsho	6072	21	susceptibility	susceptibility	NN
cord-006229-7yoilsho	6072	22	of	of	IN
cord-006229-7yoilsho	6072	23	a	a	DT
cord-006229-7yoilsho	6072	24	person	person	NN
cord-006229-7yoilsho	6072	25	to	to	IN
cord-006229-7yoilsho	6072	26	idiosyncratic	idiosyncratic	JJ
cord-006229-7yoilsho	6072	27	druginduced	druginduced	JJ
cord-006229-7yoilsho	6072	28	liver	liver	NN
cord-006229-7yoilsho	6072	29	injury	injury	NN
cord-006229-7yoilsho	6072	30	(	(	-LRB-
cord-006229-7yoilsho	6072	31	iDILI	iDILI	NNP
cord-006229-7yoilsho	6072	32	)	)	-RRB-
cord-006229-7yoilsho	6072	33	,	,	,
cord-006229-7yoilsho	6072	34	a	a	DT
cord-006229-7yoilsho	6072	35	particular	particular	JJ
cord-006229-7yoilsho	6072	36	severe	severe	JJ
cord-006229-7yoilsho	6072	37	form	form	NN
cord-006229-7yoilsho	6072	38	of	of	IN
cord-006229-7yoilsho	6072	39	drug	drug	NN
cord-006229-7yoilsho	6072	40	-	-	HYPH
cord-006229-7yoilsho	6072	41	induced	induce	VBN
cord-006229-7yoilsho	6072	42	liver	liver	NN
cord-006229-7yoilsho	6072	43	injury	injury	NN
cord-006229-7yoilsho	6072	44	(	(	-LRB-
cord-006229-7yoilsho	6072	45	DILI	DILI	NNP
cord-006229-7yoilsho	6072	46	)	)	-RRB-
cord-006229-7yoilsho	6072	47	.	.	.
cord-006229-7yoilsho	6073	1	In	in	IN
cord-006229-7yoilsho	6073	2	concordance	concordance	NN
cord-006229-7yoilsho	6073	3	with	with	IN
cord-006229-7yoilsho	6073	4	the	the	DT
cord-006229-7yoilsho	6073	5	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	6073	6	stress	stress	NN
cord-006229-7yoilsho	6073	7	hypothesis	hypothesis	NN
cord-006229-7yoilsho	6073	8	,	,	,
cord-006229-7yoilsho	6073	9	modest	modest	JJ
cord-006229-7yoilsho	6073	10	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	6073	11	stress	stress	NN
cord-006229-7yoilsho	6073	12	can	can	MD
cord-006229-7yoilsho	6073	13	lower	lower	VB
cord-006229-7yoilsho	6073	14	the	the	DT
cord-006229-7yoilsho	6073	15	threshold	threshold	NN
cord-006229-7yoilsho	6073	16	for	for	IN
cord-006229-7yoilsho	6073	17	hepatotoxicity	hepatotoxicity	NN
cord-006229-7yoilsho	6073	18	and	and	CC
cord-006229-7yoilsho	6073	19	make	make	VB
cord-006229-7yoilsho	6073	20	an	an	DT
cord-006229-7yoilsho	6073	21	individual	individual	NN
cord-006229-7yoilsho	6073	22	susceptible	susceptible	JJ
cord-006229-7yoilsho	6073	23	to	to	TO
cord-006229-7yoilsho	6073	24	develop	develop	VB
cord-006229-7yoilsho	6073	25	liver	liver	NN
cord-006229-7yoilsho	6073	26	injury	injury	NN
cord-006229-7yoilsho	6073	27	during	during	IN
cord-006229-7yoilsho	6073	28	exposure	exposure	NN
cord-006229-7yoilsho	6073	29	to	to	IN
cord-006229-7yoilsho	6073	30	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	6073	31	doses	dose	NNS
cord-006229-7yoilsho	6073	32	of	of	IN
cord-006229-7yoilsho	6073	33	a	a	DT
cord-006229-7yoilsho	6073	34	drug	drug	NN
cord-006229-7yoilsho	6073	35	.	.	.
cord-006229-7yoilsho	6074	1	In	in	IN
cord-006229-7yoilsho	6074	2	order	order	NN
cord-006229-7yoilsho	6074	3	to	to	TO
cord-006229-7yoilsho	6074	4	evaluate	evaluate	VB
cord-006229-7yoilsho	6074	5	the	the	DT
cord-006229-7yoilsho	6074	6	role	role	NN
cord-006229-7yoilsho	6074	7	of	of	IN
cord-006229-7yoilsho	6074	8	immune	immune	JJ
cord-006229-7yoilsho	6074	9	cells	cell	NNS
cord-006229-7yoilsho	6074	10	and	and	CC
cord-006229-7yoilsho	6074	11	its	-PRON-	PRP$
cord-006229-7yoilsho	6074	12	secreted	secrete	VBN
cord-006229-7yoilsho	6074	13	factors	factor	NNS
cord-006229-7yoilsho	6074	14	during	during	IN
cord-006229-7yoilsho	6074	15	drug	drug	NN
cord-006229-7yoilsho	6074	16	therapy	therapy	NN
cord-006229-7yoilsho	6074	17	,	,	,
cord-006229-7yoilsho	6074	18	we	-PRON-	PRP
cord-006229-7yoilsho	6074	19	established	establish	VBD
cord-006229-7yoilsho	6074	20	an	an	DT
cord-006229-7yoilsho	6074	21	in	in	FW
cord-006229-7yoilsho	6074	22	vitro	vitro	FW
cord-006229-7yoilsho	6074	23	test	test	NN
cord-006229-7yoilsho	6074	24	battery	battery	NN
cord-006229-7yoilsho	6074	25	consisting	consist	VBG
cord-006229-7yoilsho	6074	26	of	of	IN
cord-006229-7yoilsho	6074	27	two	two	CD
cord-006229-7yoilsho	6074	28	cell	cell	NN
cord-006229-7yoilsho	6074	29	culture	culture	NN
cord-006229-7yoilsho	6074	30	systems	system	NNS
cord-006229-7yoilsho	6074	31	in	in	IN
cord-006229-7yoilsho	6074	32	presence	presence	NN
cord-006229-7yoilsho	6074	33	or	or	CC
cord-006229-7yoilsho	6074	34	absence	absence	NN
cord-006229-7yoilsho	6074	35	of	of	IN
cord-006229-7yoilsho	6074	36	proinflammatory	proinflammatory	JJ
cord-006229-7yoilsho	6074	37	factors	factor	NNS
cord-006229-7yoilsho	6074	38	(	(	-LRB-
cord-006229-7yoilsho	6074	39	LPS	LPS	NNP
cord-006229-7yoilsho	6074	40	,	,	,
cord-006229-7yoilsho	6074	41	TNFα	TNFα	NNP
cord-006229-7yoilsho	6074	42	)	)	-RRB-
cord-006229-7yoilsho	6074	43	:	:	:
cord-006229-7yoilsho	6075	1	(	(	-LRB-
cord-006229-7yoilsho	6075	2	A	a	NN
cord-006229-7yoilsho	6075	3	)	)	-RRB-
cord-006229-7yoilsho	6075	4	the	the	DT
cord-006229-7yoilsho	6075	5	monoculture	monoculture	NN
cord-006229-7yoilsho	6075	6	of	of	IN
cord-006229-7yoilsho	6075	7	human	human	JJ
cord-006229-7yoilsho	6075	8	hepatoma	hepatoma	NN
cord-006229-7yoilsho	6075	9	(	(	-LRB-
cord-006229-7yoilsho	6075	10	HepG2	HepG2	NNP
cord-006229-7yoilsho	6075	11	)	)	-RRB-
cord-006229-7yoilsho	6075	12	cells	cell	NNS
cord-006229-7yoilsho	6075	13	and	and	CC
cord-006229-7yoilsho	6075	14	(	(	-LRB-
cord-006229-7yoilsho	6075	15	B	b	NN
cord-006229-7yoilsho	6075	16	)	)	-RRB-
cord-006229-7yoilsho	6075	17	co	co	JJ
cord-006229-7yoilsho	6075	18	-	-	JJ
cord-006229-7yoilsho	6075	19	culture	culture	JJ
cord-006229-7yoilsho	6075	20	systems	system	NNS
cord-006229-7yoilsho	6075	21	of	of	IN
cord-006229-7yoilsho	6075	22	human	human	JJ
cord-006229-7yoilsho	6075	23	monocytic	monocytic	JJ
cord-006229-7yoilsho	6075	24	or	or	CC
cord-006229-7yoilsho	6075	25	macrophage	macrophage	NN
cord-006229-7yoilsho	6075	26	-	-	HYPH
cord-006229-7yoilsho	6075	27	like	like	JJ
cord-006229-7yoilsho	6075	28	(	(	-LRB-
cord-006229-7yoilsho	6075	29	THP-1	THP-1	NNP
cord-006229-7yoilsho	6075	30	)	)	-RRB-
cord-006229-7yoilsho	6075	31	and	and	CC
cord-006229-7yoilsho	6075	32	HepG2	HepG2	NNP
cord-006229-7yoilsho	6075	33	cells	cell	NNS
cord-006229-7yoilsho	6075	34	.	.	.
cord-006229-7yoilsho	6076	1	With	with	IN
cord-006229-7yoilsho	6076	2	these	these	DT
cord-006229-7yoilsho	6076	3	different	different	JJ
cord-006229-7yoilsho	6076	4	test	test	NN
cord-006229-7yoilsho	6076	5	settings	setting	NNS
cord-006229-7yoilsho	6076	6	we	-PRON-	PRP
cord-006229-7yoilsho	6076	7	aimed	aim	VBD
cord-006229-7yoilsho	6076	8	to	to	TO
cord-006229-7yoilsho	6076	9	identify	identify	VB
cord-006229-7yoilsho	6076	10	whether	whether	IN
cord-006229-7yoilsho	6076	11	the	the	DT
cord-006229-7yoilsho	6076	12	introduction	introduction	NN
cord-006229-7yoilsho	6076	13	of	of	IN
cord-006229-7yoilsho	6076	14	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	6076	15	immune	immune	JJ
cord-006229-7yoilsho	6076	16	cells	cell	NNS
cord-006229-7yoilsho	6076	17	and/or	and/or	CC
cord-006229-7yoilsho	6076	18	pro	pro	JJ
cord-006229-7yoilsho	6076	19	-	-	JJ
cord-006229-7yoilsho	6076	20	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	6076	21	factors	factor	NNS
cord-006229-7yoilsho	6076	22	could	could	MD
cord-006229-7yoilsho	6076	23	increase	increase	VB
cord-006229-7yoilsho	6076	24	the	the	DT
cord-006229-7yoilsho	6076	25	sensitivity	sensitivity	NN
cord-006229-7yoilsho	6076	26	of	of	IN
cord-006229-7yoilsho	6076	27	liver	liver	NN
cord-006229-7yoilsho	6076	28	cells	cell	NNS
cord-006229-7yoilsho	6076	29	towards	towards	IN
cord-006229-7yoilsho	6076	30	iDILI	iDILI	NNP
cord-006229-7yoilsho	6076	31	compounds	compound	NNS
cord-006229-7yoilsho	6076	32	.	.	.
cord-006229-7yoilsho	6077	1	Three	three	CD
cord-006229-7yoilsho	6077	2	reference	reference	NN
cord-006229-7yoilsho	6077	3	substance	substance	NN
cord-006229-7yoilsho	6077	4	pairs	pair	NNS
cord-006229-7yoilsho	6077	5	were	be	VBD
cord-006229-7yoilsho	6077	6	tested	test	VBN
cord-006229-7yoilsho	6077	7	,	,	,
cord-006229-7yoilsho	6077	8	namely	namely	RB
cord-006229-7yoilsho	6077	9	Troglitazone	Troglitazone	NNP
cord-006229-7yoilsho	6077	10	-Rosiglitazone	-Rosiglitazone	NNP
cord-006229-7yoilsho	6077	11	,	,	,
cord-006229-7yoilsho	6077	12	Trovafloxacin	Trovafloxacin	NNP
cord-006229-7yoilsho	6077	13	-Levofloxacin	-Levofloxacin	NNP
cord-006229-7yoilsho	6077	14	,	,	,
cord-006229-7yoilsho	6077	15	and	and	CC
cord-006229-7yoilsho	6077	16	Diclofenac	Diclofenac	NNP
cord-006229-7yoilsho	6077	17	-Acetylsalicylic	-acetylsalicylic	NN
cord-006229-7yoilsho	6077	18	Acid	acid	NN
cord-006229-7yoilsho	6077	19	,	,	,
cord-006229-7yoilsho	6077	20	each	each	DT
cord-006229-7yoilsho	6077	21	of	of	IN
cord-006229-7yoilsho	6077	22	them	-PRON-	PRP
cord-006229-7yoilsho	6077	23	being	be	VBG
cord-006229-7yoilsho	6077	24	composed	compose	VBN
cord-006229-7yoilsho	6077	25	of	of	IN
cord-006229-7yoilsho	6077	26	a	a	DT
cord-006229-7yoilsho	6077	27	compound	compound	NN
cord-006229-7yoilsho	6077	28	that	that	WDT
cord-006229-7yoilsho	6077	29	is	be	VBZ
cord-006229-7yoilsho	6077	30	known	know	VBN
cord-006229-7yoilsho	6077	31	to	to	TO
cord-006229-7yoilsho	6077	32	induce	induce	VB
cord-006229-7yoilsho	6077	33	iDILI	iDILI	NNP
cord-006229-7yoilsho	6077	34	and	and	CC
cord-006229-7yoilsho	6077	35	a	a	DT
cord-006229-7yoilsho	6077	36	partner	partner	NN
cord-006229-7yoilsho	6077	37	compound	compound	NN
cord-006229-7yoilsho	6077	38	of	of	IN
cord-006229-7yoilsho	6077	39	the	the	DT
cord-006229-7yoilsho	6077	40	same	same	JJ
cord-006229-7yoilsho	6077	41	substance	substance	NN
cord-006229-7yoilsho	6077	42	class	class	NN
cord-006229-7yoilsho	6077	43	that	that	WDT
cord-006229-7yoilsho	6077	44	does	do	VBZ
cord-006229-7yoilsho	6077	45	not	not	RB
cord-006229-7yoilsho	6077	46	induce	induce	VB
cord-006229-7yoilsho	6077	47	iDILI	iDILI	NNP
cord-006229-7yoilsho	6077	48	.	.	.
cord-006229-7yoilsho	6078	1	First	first	RB
cord-006229-7yoilsho	6078	2	,	,	,
cord-006229-7yoilsho	6078	3	all	all	DT
cord-006229-7yoilsho	6078	4	compounds	compound	NNS
cord-006229-7yoilsho	6078	5	were	be	VBD
cord-006229-7yoilsho	6078	6	tested	test	VBN
cord-006229-7yoilsho	6078	7	for	for	IN
cord-006229-7yoilsho	6078	8	cytotoxicity	cytotoxicity	NN
cord-006229-7yoilsho	6078	9	towards	towards	IN
cord-006229-7yoilsho	6078	10	the	the	DT
cord-006229-7yoilsho	6078	11	single	single	JJ
cord-006229-7yoilsho	6078	12	cell	cell	NN
cord-006229-7yoilsho	6078	13	systems	system	NNS
cord-006229-7yoilsho	6078	14	using	use	VBG
cord-006229-7yoilsho	6078	15	the	the	DT
cord-006229-7yoilsho	6078	16	WST	WST	NNP
cord-006229-7yoilsho	6078	17	-	-	HYPH
cord-006229-7yoilsho	6078	18	assay	assay	NN
cord-006229-7yoilsho	6078	19	.	.	.
cord-006229-7yoilsho	6079	1	Co	co	NN
cord-006229-7yoilsho	6079	2	-	-	NN
cord-006229-7yoilsho	6079	3	culture	culture	NN
cord-006229-7yoilsho	6079	4	experiments	experiment	NNS
cord-006229-7yoilsho	6079	5	with	with	IN
cord-006229-7yoilsho	6079	6	HepG2	HepG2	NNP
cord-006229-7yoilsho	6079	7	and	and	CC
cord-006229-7yoilsho	6079	8	THP-1	THP-1	NNP
cord-006229-7yoilsho	6079	9	monocytes	monocyte	NNS
cord-006229-7yoilsho	6079	10	or	or	CC
cord-006229-7yoilsho	6079	11	macrophages	macrophage	NNS
cord-006229-7yoilsho	6079	12	as	as	RB
cord-006229-7yoilsho	6079	13	well	well	RB
cord-006229-7yoilsho	6079	14	as	as	IN
cord-006229-7yoilsho	6079	15	co	co	NN
cord-006229-7yoilsho	6079	16	-	-	NN
cord-006229-7yoilsho	6079	17	exposure	exposure	JJ
cord-006229-7yoilsho	6079	18	experiments	experiment	NNS
cord-006229-7yoilsho	6079	19	with	with	IN
cord-006229-7yoilsho	6079	20	LPS	LPS	NNP
cord-006229-7yoilsho	6079	21	or	or	CC
cord-006229-7yoilsho	6079	22	TNFα	TNFα	NNS
cord-006229-7yoilsho	6079	23	were	be	VBD
cord-006229-7yoilsho	6079	24	then	then	RB
cord-006229-7yoilsho	6079	25	done	do	VBN
cord-006229-7yoilsho	6079	26	at	at	IN
cord-006229-7yoilsho	6079	27	about	about	RB
cord-006229-7yoilsho	6079	28	20	20	CD
cord-006229-7yoilsho	6079	29	%	%	NN
cord-006229-7yoilsho	6079	30	cytotoxicity	cytotoxicity	NN
cord-006229-7yoilsho	6079	31	of	of	IN
cord-006229-7yoilsho	6079	32	the	the	DT
cord-006229-7yoilsho	6079	33	respective	respective	JJ
cord-006229-7yoilsho	6079	34	substance	substance	NN
cord-006229-7yoilsho	6079	35	in	in	IN
cord-006229-7yoilsho	6079	36	the	the	DT
cord-006229-7yoilsho	6079	37	most	most	RBS
cord-006229-7yoilsho	6079	38	sensitive	sensitive	JJ
cord-006229-7yoilsho	6079	39	cell	cell	NN
cord-006229-7yoilsho	6079	40	type	type	NN
cord-006229-7yoilsho	6079	41	.	.	.
cord-006229-7yoilsho	6080	1	Subsequently	subsequently	RB
cord-006229-7yoilsho	6080	2	the	the	DT
cord-006229-7yoilsho	6080	3	results	result	NNS
cord-006229-7yoilsho	6080	4	were	be	VBD
cord-006229-7yoilsho	6080	5	compared	compare	VBN
cord-006229-7yoilsho	6080	6	to	to	IN
cord-006229-7yoilsho	6080	7	the	the	DT
cord-006229-7yoilsho	6080	8	experiments	experiment	NNS
cord-006229-7yoilsho	6080	9	in	in	IN
cord-006229-7yoilsho	6080	10	the	the	DT
cord-006229-7yoilsho	6080	11	monoculture	monoculture	NN
cord-006229-7yoilsho	6080	12	of	of	IN
cord-006229-7yoilsho	6080	13	HepG2	HepG2	NNP
cord-006229-7yoilsho	6080	14	.	.	.
cord-006229-7yoilsho	6081	1	We	-PRON-	PRP
cord-006229-7yoilsho	6081	2	observed	observe	VBD
cord-006229-7yoilsho	6081	3	that	that	IN
cord-006229-7yoilsho	6081	4	every	every	DT
cord-006229-7yoilsho	6081	5	iDILI	iDILI	NNP
cord-006229-7yoilsho	6081	6	compound	compound	NN
cord-006229-7yoilsho	6081	7	showed	show	VBD
cord-006229-7yoilsho	6081	8	a	a	DT
cord-006229-7yoilsho	6081	9	significant	significant	JJ
cord-006229-7yoilsho	6081	10	increase	increase	NN
cord-006229-7yoilsho	6081	11	in	in	IN
cord-006229-7yoilsho	6081	12	cytotoxicity	cytotoxicity	NN
cord-006229-7yoilsho	6081	13	in	in	IN
cord-006229-7yoilsho	6081	14	a	a	DT
cord-006229-7yoilsho	6081	15	minimum	minimum	NN
cord-006229-7yoilsho	6081	16	of	of	IN
cord-006229-7yoilsho	6081	17	one	one	CD
cord-006229-7yoilsho	6081	18	exposure	exposure	NN
cord-006229-7yoilsho	6081	19	combination	combination	NN
cord-006229-7yoilsho	6081	20	while	while	IN
cord-006229-7yoilsho	6081	21	this	this	DT
cord-006229-7yoilsho	6081	22	effect	effect	NN
cord-006229-7yoilsho	6081	23	was	be	VBD
cord-006229-7yoilsho	6081	24	not	not	RB
cord-006229-7yoilsho	6081	25	observed	observe	VBN
cord-006229-7yoilsho	6081	26	with	with	IN
cord-006229-7yoilsho	6081	27	the	the	DT
cord-006229-7yoilsho	6081	28	corresponding	corresponding	JJ
cord-006229-7yoilsho	6081	29	non	non	JJ
cord-006229-7yoilsho	6081	30	-	-	JJ
cord-006229-7yoilsho	6081	31	DILI	dili	JJ
cord-006229-7yoilsho	6081	32	partner	partner	NN
cord-006229-7yoilsho	6081	33	compound	compound	NN
cord-006229-7yoilsho	6081	34	.	.	.
cord-006229-7yoilsho	6082	1	In	in	IN
cord-006229-7yoilsho	6082	2	conclusion	conclusion	NN
cord-006229-7yoilsho	6082	3	,	,	,
cord-006229-7yoilsho	6082	4	a	a	DT
cord-006229-7yoilsho	6082	5	combination	combination	NN
cord-006229-7yoilsho	6082	6	of	of	IN
cord-006229-7yoilsho	6082	7	different	different	JJ
cord-006229-7yoilsho	6082	8	culture	culture	NN
cord-006229-7yoilsho	6082	9	systems	system	NNS
cord-006229-7yoilsho	6082	10	and	and	CC
cord-006229-7yoilsho	6082	11	co	co	NNS
cord-006229-7yoilsho	6082	12	-	-	NNS
cord-006229-7yoilsho	6082	13	exposures	exposure	NNS
cord-006229-7yoilsho	6082	14	with	with	IN
cord-006229-7yoilsho	6082	15	proinflammatory	proinflammatory	JJ
cord-006229-7yoilsho	6082	16	factors	factor	NNS
cord-006229-7yoilsho	6082	17	is	be	VBZ
cord-006229-7yoilsho	6082	18	needed	need	VBN
cord-006229-7yoilsho	6082	19	for	for	IN
cord-006229-7yoilsho	6082	20	a	a	DT
cord-006229-7yoilsho	6082	21	valid	valid	JJ
cord-006229-7yoilsho	6082	22	differentiation	differentiation	NN
cord-006229-7yoilsho	6082	23	between	between	IN
cord-006229-7yoilsho	6082	24	non	non	JJ
cord-006229-7yoilsho	6082	25	-	-	JJ
cord-006229-7yoilsho	6082	26	DILI	dili	JJ
cord-006229-7yoilsho	6082	27	and	and	CC
cord-006229-7yoilsho	6082	28	iDILI	iDILI	NNP
cord-006229-7yoilsho	6082	29	compounds	compound	NNS
cord-006229-7yoilsho	6082	30	.	.	.
cord-006229-7yoilsho	6083	1	This	this	DT
cord-006229-7yoilsho	6083	2	test	test	NN
cord-006229-7yoilsho	6083	3	battery	battery	NN
cord-006229-7yoilsho	6083	4	could	could	MD
cord-006229-7yoilsho	6083	5	provide	provide	VB
cord-006229-7yoilsho	6083	6	a	a	DT
cord-006229-7yoilsho	6083	7	useful	useful	JJ
cord-006229-7yoilsho	6083	8	tool	tool	NN
cord-006229-7yoilsho	6083	9	for	for	IN
cord-006229-7yoilsho	6083	10	the	the	DT
cord-006229-7yoilsho	6083	11	prediction	prediction	NN
cord-006229-7yoilsho	6083	12	of	of	IN
cord-006229-7yoilsho	6083	13	inflammation	inflammation	NN
cord-006229-7yoilsho	6083	14	-	-	HYPH
cord-006229-7yoilsho	6083	15	associated	associate	VBN
cord-006229-7yoilsho	6083	16	idiosyncratic	idiosyncratic	JJ
cord-006229-7yoilsho	6083	17	drug	drug	NN
cord-006229-7yoilsho	6083	18	-	-	HYPH
cord-006229-7yoilsho	6083	19	induced	induce	VBN
cord-006229-7yoilsho	6083	20	hepatotoxicity	hepatotoxicity	NN
cord-006229-7yoilsho	6083	21	.	.	.
cord-006229-7yoilsho	6084	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	6084	2	,	,	,
cord-006229-7yoilsho	6084	3	our	-PRON-	PRP$
cord-006229-7yoilsho	6084	4	results	result	NNS
cord-006229-7yoilsho	6084	5	support	support	VBP
cord-006229-7yoilsho	6084	6	the	the	DT
cord-006229-7yoilsho	6084	7	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	6084	8	stress	stress	NN
cord-006229-7yoilsho	6084	9	hypothesis	hypothesis	NN
cord-006229-7yoilsho	6084	10	and	and	CC
cord-006229-7yoilsho	6084	11	points	point	VBZ
cord-006229-7yoilsho	6084	12	to	to	IN
cord-006229-7yoilsho	6084	13	an	an	DT
cord-006229-7yoilsho	6084	14	involvement	involvement	NN
cord-006229-7yoilsho	6084	15	of	of	IN
cord-006229-7yoilsho	6084	16	proinflammatory	proinflammatory	JJ
cord-006229-7yoilsho	6084	17	factors	factor	NNS
cord-006229-7yoilsho	6084	18	in	in	IN
cord-006229-7yoilsho	6084	19	the	the	DT
cord-006229-7yoilsho	6084	20	development	development	NN
cord-006229-7yoilsho	6084	21	of	of	IN
cord-006229-7yoilsho	6084	22	iDILI	iDILI	NNP
cord-006229-7yoilsho	6084	23	.	.	.
cord-006229-7yoilsho	6085	1	Extensive	extensive	JJ
cord-006229-7yoilsho	6085	2	animal	animal	NN
cord-006229-7yoilsho	6085	3	models	model	NNS
cord-006229-7yoilsho	6085	4	of	of	IN
cord-006229-7yoilsho	6085	5	carcinogenicity	carcinogenicity	NN
cord-006229-7yoilsho	6085	6	ensure	ensure	VB
cord-006229-7yoilsho	6085	7	a	a	DT
cord-006229-7yoilsho	6085	8	safe	safe	JJ
cord-006229-7yoilsho	6085	9	usage	usage	NN
cord-006229-7yoilsho	6085	10	of	of	IN
cord-006229-7yoilsho	6085	11	chemicals	chemical	NNS
cord-006229-7yoilsho	6085	12	.	.	.
cord-006229-7yoilsho	6086	1	To	to	TO
cord-006229-7yoilsho	6086	2	elucidate	elucidate	VB
cord-006229-7yoilsho	6086	3	fundamental	fundamental	JJ
cord-006229-7yoilsho	6086	4	molecular	molecular	JJ
cord-006229-7yoilsho	6086	5	mechanisms	mechanism	NNS
cord-006229-7yoilsho	6086	6	of	of	IN
cord-006229-7yoilsho	6086	7	carcinogenicity	carcinogenicity	NN
cord-006229-7yoilsho	6086	8	these	these	DT
cord-006229-7yoilsho	6086	9	methods	method	NNS
cord-006229-7yoilsho	6086	10	are	be	VBP
cord-006229-7yoilsho	6086	11	expensive	expensive	JJ
cord-006229-7yoilsho	6086	12	,	,	,
cord-006229-7yoilsho	6086	13	time	time	NN
cord-006229-7yoilsho	6086	14	consuming	consume	VBG
cord-006229-7yoilsho	6086	15	and	and	CC
cord-006229-7yoilsho	6086	16	above	above	IN
cord-006229-7yoilsho	6086	17	all	all	RB
cord-006229-7yoilsho	6086	18	too	too	RB
cord-006229-7yoilsho	6086	19	complex	complex	JJ
cord-006229-7yoilsho	6086	20	.	.	.
cord-006229-7yoilsho	6087	1	In	in	IN
cord-006229-7yoilsho	6087	2	contrast	contrast	NN
cord-006229-7yoilsho	6087	3	,	,	,
cord-006229-7yoilsho	6087	4	most	most	JJS
cord-006229-7yoilsho	6087	5	in	in	IN
cord-006229-7yoilsho	6087	6	vitro	vitro	FW
cord-006229-7yoilsho	6087	7	methods	method	NNS
cord-006229-7yoilsho	6087	8	are	be	VBP
cord-006229-7yoilsho	6087	9	rather	rather	RB
cord-006229-7yoilsho	6087	10	simple	simple	JJ
cord-006229-7yoilsho	6087	11	and	and	CC
cord-006229-7yoilsho	6087	12	detect	detect	VBP
cord-006229-7yoilsho	6087	13	only	only	RB
cord-006229-7yoilsho	6087	14	selected	select	VBN
cord-006229-7yoilsho	6087	15	endpoints	endpoint	NNS
cord-006229-7yoilsho	6087	16	,	,	,
cord-006229-7yoilsho	6087	17	like	like	IN
cord-006229-7yoilsho	6087	18	DNA	dna	NN
cord-006229-7yoilsho	6087	19	damage	damage	NN
cord-006229-7yoilsho	6087	20	,	,	,
cord-006229-7yoilsho	6087	21	mutations	mutation	NNS
cord-006229-7yoilsho	6087	22	or	or	CC
cord-006229-7yoilsho	6087	23	changes	change	NNS
cord-006229-7yoilsho	6087	24	in	in	IN
cord-006229-7yoilsho	6087	25	proliferation	proliferation	NN
cord-006229-7yoilsho	6087	26	.	.	.
cord-006229-7yoilsho	6088	1	The	the	DT
cord-006229-7yoilsho	6088	2	BALB	BALB	NNP
cord-006229-7yoilsho	6088	3	/	/	SYM
cord-006229-7yoilsho	6088	4	c	c	NN
cord-006229-7yoilsho	6088	5	cell	cell	NN
cord-006229-7yoilsho	6088	6	transformation	transformation	NN
cord-006229-7yoilsho	6088	7	assay	assay	NN
cord-006229-7yoilsho	6088	8	is	be	VBZ
cord-006229-7yoilsho	6088	9	a	a	DT
cord-006229-7yoilsho	6088	10	validated	validate	VBN
cord-006229-7yoilsho	6088	11	toxicological	toxicological	JJ
cord-006229-7yoilsho	6088	12	method	method	NN
cord-006229-7yoilsho	6088	13	to	to	TO
cord-006229-7yoilsho	6088	14	identify	identify	VB
cord-006229-7yoilsho	6088	15	potential	potential	JJ
cord-006229-7yoilsho	6088	16	tumour	tumour	NN
cord-006229-7yoilsho	6088	17	initiators	initiator	NNS
cord-006229-7yoilsho	6088	18	and	and	CC
cord-006229-7yoilsho	6088	19	promotors	promotor	NNS
cord-006229-7yoilsho	6088	20	.	.	.
cord-006229-7yoilsho	6089	1	First	first	RB
cord-006229-7yoilsho	6089	2	,	,	,
cord-006229-7yoilsho	6089	3	BALB	BALB	NNP
cord-006229-7yoilsho	6089	4	/	/	SYM
cord-006229-7yoilsho	6089	5	c	c	NN
cord-006229-7yoilsho	6089	6	mouse	mouse	NN
cord-006229-7yoilsho	6089	7	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	6089	8	form	form	VBP
cord-006229-7yoilsho	6089	9	a	a	DT
cord-006229-7yoilsho	6089	10	monolayer	monolayer	NN
cord-006229-7yoilsho	6089	11	culture	culture	NN
cord-006229-7yoilsho	6089	12	and	and	CC
cord-006229-7yoilsho	6089	13	get	get	VB
cord-006229-7yoilsho	6089	14	contact	contact	NN
cord-006229-7yoilsho	6089	15	-	-	HYPH
cord-006229-7yoilsho	6089	16	inhibited	inhibit	VBN
cord-006229-7yoilsho	6089	17	after	after	IN
cord-006229-7yoilsho	6089	18	reaching	reach	VBG
cord-006229-7yoilsho	6089	19	confluence	confluence	NN
cord-006229-7yoilsho	6089	20	.	.	.
cord-006229-7yoilsho	6090	1	Upon	upon	IN
cord-006229-7yoilsho	6090	2	treatment	treatment	NN
cord-006229-7yoilsho	6090	3	with	with	IN
cord-006229-7yoilsho	6090	4	a	a	DT
cord-006229-7yoilsho	6090	5	tumour	tumour	NN
cord-006229-7yoilsho	6090	6	initiator	initiator	NN
cord-006229-7yoilsho	6090	7	(	(	-LRB-
cord-006229-7yoilsho	6090	8	3-Methylcholanthrene	3-Methylcholanthrene	NNP
cord-006229-7yoilsho	6090	9	)	)	-RRB-
cord-006229-7yoilsho	6090	10	and	and	CC
cord-006229-7yoilsho	6090	11	promotor	promotor	NN
cord-006229-7yoilsho	6090	12	(	(	-LRB-
cord-006229-7yoilsho	6090	13	12-O	12-O	NNP
cord-006229-7yoilsho	6090	14	-	-	HYPH
cord-006229-7yoilsho	6090	15	Tetradecanoylphorbol-13-acetate	tetradecanoylphorbol-13-acetate	NN
cord-006229-7yoilsho	6090	16	)	)	-RRB-
cord-006229-7yoilsho	6090	17	transformed	transform	VBN
cord-006229-7yoilsho	6090	18	cells	cell	NNS
cord-006229-7yoilsho	6090	19	do	do	VBP
cord-006229-7yoilsho	6090	20	not	not	RB
cord-006229-7yoilsho	6090	21	stop	stop	VB
cord-006229-7yoilsho	6090	22	proliferation	proliferation	NN
cord-006229-7yoilsho	6090	23	and	and	CC
cord-006229-7yoilsho	6090	24	grow	grow	VB
cord-006229-7yoilsho	6090	25	as	as	IN
cord-006229-7yoilsho	6090	26	morphologically	morphologically	RB
cord-006229-7yoilsho	6090	27	aberrant	aberrant	JJ
cord-006229-7yoilsho	6090	28	foci	foci	NN
cord-006229-7yoilsho	6090	29	over	over	IN
cord-006229-7yoilsho	6090	30	the	the	DT
cord-006229-7yoilsho	6090	31	monolayer	monolayer	NN
cord-006229-7yoilsho	6090	32	of	of	IN
cord-006229-7yoilsho	6090	33	normal	normal	JJ
cord-006229-7yoilsho	6090	34	cells	cell	NNS
cord-006229-7yoilsho	6090	35	.	.	.
cord-006229-7yoilsho	6091	1	After	after	IN
cord-006229-7yoilsho	6091	2	fixation	fixation	NN
cord-006229-7yoilsho	6091	3	with	with	IN
cord-006229-7yoilsho	6091	4	methanol	methanol	NN
cord-006229-7yoilsho	6091	5	at	at	IN
cord-006229-7yoilsho	6091	6	day	day	NN
cord-006229-7yoilsho	6091	7	42	42	CD
cord-006229-7yoilsho	6091	8	,	,	,
cord-006229-7yoilsho	6091	9	morphological	morphological	JJ
cord-006229-7yoilsho	6091	10	aberrant	aberrant	JJ
cord-006229-7yoilsho	6091	11	foci	foci	NN
cord-006229-7yoilsho	6091	12	can	can	MD
cord-006229-7yoilsho	6091	13	be	be	VB
cord-006229-7yoilsho	6091	14	visualized	visualize	VBN
cord-006229-7yoilsho	6091	15	with	with	IN
cord-006229-7yoilsho	6091	16	giemsa	giemsa	JJ
cord-006229-7yoilsho	6091	17	staining	stain	VBG
cord-006229-7yoilsho	6091	18	.	.	.
cord-006229-7yoilsho	6092	1	Because	because	IN
cord-006229-7yoilsho	6092	2	the	the	DT
cord-006229-7yoilsho	6092	3	BALB	BALB	NNP
cord-006229-7yoilsho	6092	4	/	/	SYM
cord-006229-7yoilsho	6092	5	c	c	NN
cord-006229-7yoilsho	6092	6	assay	assay	NN
cord-006229-7yoilsho	6092	7	mimics	mimic	VBZ
cord-006229-7yoilsho	6092	8	different	different	JJ
cord-006229-7yoilsho	6092	9	stages	stage	NNS
cord-006229-7yoilsho	6092	10	of	of	IN
cord-006229-7yoilsho	6092	11	the	the	DT
cord-006229-7yoilsho	6092	12	malignant	malignant	JJ
cord-006229-7yoilsho	6092	13	cell	cell	NN
cord-006229-7yoilsho	6092	14	transformation	transformation	NN
cord-006229-7yoilsho	6092	15	process	process	NN
cord-006229-7yoilsho	6092	16	(	(	-LRB-
cord-006229-7yoilsho	6092	17	initiation	initiation	NN
cord-006229-7yoilsho	6092	18	,	,	,
cord-006229-7yoilsho	6092	19	promotion	promotion	NN
cord-006229-7yoilsho	6092	20	and	and	CC
cord-006229-7yoilsho	6092	21	post	post	JJ
cord-006229-7yoilsho	6092	22	-	-	JJ
cord-006229-7yoilsho	6092	23	promotion	promotion	JJ
cord-006229-7yoilsho	6092	24	phase	phase	NN
cord-006229-7yoilsho	6092	25	)	)	-RRB-
cord-006229-7yoilsho	6092	26	and	and	CC
cord-006229-7yoilsho	6092	27	detects	detect	VBZ
cord-006229-7yoilsho	6092	28	with	with	IN
cord-006229-7yoilsho	6092	29	the	the	DT
cord-006229-7yoilsho	6092	30	colony	colony	NN
cord-006229-7yoilsho	6092	31	formation	formation	NN
cord-006229-7yoilsho	6092	32	a	a	DT
cord-006229-7yoilsho	6092	33	late	late	JJ
cord-006229-7yoilsho	6092	34	endpoint	endpoint	NN
cord-006229-7yoilsho	6092	35	of	of	IN
cord-006229-7yoilsho	6092	36	carcinogenicity	carcinogenicity	NN
cord-006229-7yoilsho	6092	37	we	-PRON-	PRP
cord-006229-7yoilsho	6092	38	improved	improve	VBD
cord-006229-7yoilsho	6092	39	this	this	DT
cord-006229-7yoilsho	6092	40	method	method	NN
cord-006229-7yoilsho	6092	41	for	for	IN
cord-006229-7yoilsho	6092	42	mechanistic	mechanistic	JJ
cord-006229-7yoilsho	6092	43	cancer	cancer	NN
cord-006229-7yoilsho	6092	44	research	research	NN
cord-006229-7yoilsho	6092	45	.	.	.
cord-006229-7yoilsho	6093	1	Using	use	VBG
cord-006229-7yoilsho	6093	2	the	the	DT
cord-006229-7yoilsho	6093	3	example	example	NN
cord-006229-7yoilsho	6093	4	of	of	IN
cord-006229-7yoilsho	6093	5	insulin	insulin	NN
cord-006229-7yoilsho	6093	6	-	-	HYPH
cord-006229-7yoilsho	6093	7	signalling	signal	VBG
cord-006229-7yoilsho	6093	8	pathway	pathway	NN
cord-006229-7yoilsho	6093	9	we	-PRON-	PRP
cord-006229-7yoilsho	6093	10	can	can	MD
cord-006229-7yoilsho	6093	11	show	show	VB
cord-006229-7yoilsho	6093	12	that	that	IN
cord-006229-7yoilsho	6093	13	(	(	-LRB-
cord-006229-7yoilsho	6093	14	1	1	CD
cord-006229-7yoilsho	6093	15	)	)	-RRB-
cord-006229-7yoilsho	6093	16	several	several	JJ
cord-006229-7yoilsho	6093	17	substances	substance	NNS
cord-006229-7yoilsho	6093	18	have	have	VBP
cord-006229-7yoilsho	6093	19	a	a	DT
cord-006229-7yoilsho	6093	20	different	different	JJ
cord-006229-7yoilsho	6093	21	impact	impact	NN
cord-006229-7yoilsho	6093	22	on	on	IN
cord-006229-7yoilsho	6093	23	the	the	DT
cord-006229-7yoilsho	6093	24	transformation	transformation	NN
cord-006229-7yoilsho	6093	25	process	process	NN
cord-006229-7yoilsho	6093	26	,	,	,
cord-006229-7yoilsho	6093	27	(	(	-LRB-
cord-006229-7yoilsho	6093	28	2	2	LS
cord-006229-7yoilsho	6093	29	)	)	-RRB-
cord-006229-7yoilsho	6093	30	it	-PRON-	PRP
cord-006229-7yoilsho	6093	31	is	be	VBZ
cord-006229-7yoilsho	6093	32	possible	possible	JJ
cord-006229-7yoilsho	6093	33	to	to	TO
cord-006229-7yoilsho	6093	34	identify	identify	VB
cord-006229-7yoilsho	6093	35	for	for	IN
cord-006229-7yoilsho	6093	36	each	each	DT
cord-006229-7yoilsho	6093	37	substance	substance	NN
cord-006229-7yoilsho	6093	38	the	the	DT
cord-006229-7yoilsho	6093	39	phase	phase	NN
cord-006229-7yoilsho	6093	40	with	with	IN
cord-006229-7yoilsho	6093	41	the	the	DT
cord-006229-7yoilsho	6093	42	greatest	great	JJS
cord-006229-7yoilsho	6093	43	effectiveness	effectiveness	NN
cord-006229-7yoilsho	6093	44	and	and	CC
cord-006229-7yoilsho	6093	45	(	(	-LRB-
cord-006229-7yoilsho	6093	46	3	3	LS
cord-006229-7yoilsho	6093	47	)	)	-RRB-
cord-006229-7yoilsho	6093	48	we	-PRON-	PRP
cord-006229-7yoilsho	6093	49	can	can	MD
cord-006229-7yoilsho	6093	50	detect	detect	VB
cord-006229-7yoilsho	6093	51	additional	additional	JJ
cord-006229-7yoilsho	6093	52	endpoints	endpoint	NNS
cord-006229-7yoilsho	6093	53	to	to	TO
cord-006229-7yoilsho	6093	54	elucidate	elucidate	VB
cord-006229-7yoilsho	6093	55	the	the	DT
cord-006229-7yoilsho	6093	56	mechanistic	mechanistic	JJ
cord-006229-7yoilsho	6093	57	mode	mode	NN
cord-006229-7yoilsho	6093	58	of	of	IN
cord-006229-7yoilsho	6093	59	action	action	NN
cord-006229-7yoilsho	6093	60	.	.	.
cord-006229-7yoilsho	6094	1	Therefore	therefore	RB
cord-006229-7yoilsho	6094	2	we	-PRON-	PRP
cord-006229-7yoilsho	6094	3	used	use	VBD
cord-006229-7yoilsho	6094	4	several	several	JJ
cord-006229-7yoilsho	6094	5	compounds	compound	NNS
cord-006229-7yoilsho	6094	6	(	(	-LRB-
cord-006229-7yoilsho	6094	7	Linsitinib	Linsitinib	NNP
cord-006229-7yoilsho	6094	8	,	,	,
cord-006229-7yoilsho	6094	9	Metformin	Metformin	NNP
cord-006229-7yoilsho	6094	10	,	,	,
cord-006229-7yoilsho	6094	11	Rapamycin	Rapamycin	NNP
cord-006229-7yoilsho	6094	12	,	,	,
cord-006229-7yoilsho	6094	13	…	…	NFP
cord-006229-7yoilsho	6094	14	)	)	-RRB-
cord-006229-7yoilsho	6094	15	to	to	TO
cord-006229-7yoilsho	6094	16	manipulate	manipulate	VB
cord-006229-7yoilsho	6094	17	the	the	DT
cord-006229-7yoilsho	6094	18	insulin	insulin	NN
cord-006229-7yoilsho	6094	19	-	-	HYPH
cord-006229-7yoilsho	6094	20	signalling	signal	VBG
cord-006229-7yoilsho	6094	21	pathway	pathway	NN
cord-006229-7yoilsho	6094	22	on	on	IN
cord-006229-7yoilsho	6094	23	different	different	JJ
cord-006229-7yoilsho	6094	24	levels	level	NNS
cord-006229-7yoilsho	6094	25	(	(	-LRB-
cord-006229-7yoilsho	6094	26	InsR	InsR	NNP
cord-006229-7yoilsho	6094	27	,	,	,
cord-006229-7yoilsho	6094	28	AMPK	AMPK	NNP
cord-006229-7yoilsho	6094	29	,	,	,
cord-006229-7yoilsho	6094	30	mTOR	mTOR	NNP
cord-006229-7yoilsho	6094	31	,	,	,
cord-006229-7yoilsho	6094	32	…	…	NFP
cord-006229-7yoilsho	6094	33	)	)	-RRB-
cord-006229-7yoilsho	6094	34	and	and	CC
cord-006229-7yoilsho	6094	35	analysed	analyse	VBD
cord-006229-7yoilsho	6094	36	a	a	DT
cord-006229-7yoilsho	6094	37	number	number	NN
cord-006229-7yoilsho	6094	38	of	of	IN
cord-006229-7yoilsho	6094	39	characteristic	characteristic	JJ
cord-006229-7yoilsho	6094	40	endpoints	endpoint	NNS
cord-006229-7yoilsho	6094	41	of	of	IN
cord-006229-7yoilsho	6094	42	carcinogenesis	carcinogenesis	NN
cord-006229-7yoilsho	6094	43	.	.	.
cord-006229-7yoilsho	6095	1	Changes	change	NNS
cord-006229-7yoilsho	6095	2	on	on	IN
cord-006229-7yoilsho	6095	3	protein	protein	NN
cord-006229-7yoilsho	6095	4	level	level	NN
cord-006229-7yoilsho	6095	5	and	and	CC
cord-006229-7yoilsho	6095	6	signalling	signalling	NN
cord-006229-7yoilsho	6095	7	(	(	-LRB-
cord-006229-7yoilsho	6095	8	westernblot	westernblot	NNP
cord-006229-7yoilsho	6095	9	,	,	,
cord-006229-7yoilsho	6095	10	immunofluorescence	immunofluorescence	NN
cord-006229-7yoilsho	6095	11	,	,	,
cord-006229-7yoilsho	6095	12	flow	flow	NN
cord-006229-7yoilsho	6095	13	cytometry	cytometry	NN
cord-006229-7yoilsho	6095	14	)	)	-RRB-
cord-006229-7yoilsho	6095	15	or	or	CC
cord-006229-7yoilsho	6095	16	parameters	parameter	NNS
cord-006229-7yoilsho	6095	17	of	of	IN
cord-006229-7yoilsho	6095	18	energy	energy	NN
cord-006229-7yoilsho	6095	19	metabolism	metabolism	NN
cord-006229-7yoilsho	6095	20	(	(	-LRB-
cord-006229-7yoilsho	6095	21	oxygen	oxygen	NN
cord-006229-7yoilsho	6095	22	consumption	consumption	NN
cord-006229-7yoilsho	6095	23	,	,	,
cord-006229-7yoilsho	6095	24	glucose	glucose	NN
cord-006229-7yoilsho	6095	25	or	or	CC
cord-006229-7yoilsho	6095	26	ATP	ATP	NNP
cord-006229-7yoilsho	6095	27	measurement	measurement	NN
cord-006229-7yoilsho	6095	28	)	)	-RRB-
cord-006229-7yoilsho	6095	29	are	be	VBP
cord-006229-7yoilsho	6095	30	measurable	measurable	JJ
cord-006229-7yoilsho	6095	31	and	and	CC
cord-006229-7yoilsho	6095	32	enable	enable	VB
cord-006229-7yoilsho	6095	33	new	new	JJ
cord-006229-7yoilsho	6095	34	insights	insight	NNS
cord-006229-7yoilsho	6095	35	into	into	IN
cord-006229-7yoilsho	6095	36	the	the	DT
cord-006229-7yoilsho	6095	37	process	process	NN
cord-006229-7yoilsho	6095	38	of	of	IN
cord-006229-7yoilsho	6095	39	cancer	cancer	NN
cord-006229-7yoilsho	6095	40	origin	origin	NN
cord-006229-7yoilsho	6095	41	.	.	.
cord-006229-7yoilsho	6096	1	Summing	sum	VBG
cord-006229-7yoilsho	6096	2	up	up	RP
cord-006229-7yoilsho	6096	3	,	,	,
cord-006229-7yoilsho	6096	4	the	the	DT
cord-006229-7yoilsho	6096	5	BALB	BALB	NNP
cord-006229-7yoilsho	6096	6	/	/	SYM
cord-006229-7yoilsho	6096	7	c	c	NN
cord-006229-7yoilsho	6096	8	3T3	3t3	CD
cord-006229-7yoilsho	6096	9	assay	assay	NN
cord-006229-7yoilsho	6096	10	proves	prove	VBZ
cord-006229-7yoilsho	6096	11	to	to	TO
cord-006229-7yoilsho	6096	12	be	be	VB
cord-006229-7yoilsho	6096	13	a	a	DT
cord-006229-7yoilsho	6096	14	cheap	cheap	JJ
cord-006229-7yoilsho	6096	15	and	and	CC
cord-006229-7yoilsho	6096	16	short	short	JJ
cord-006229-7yoilsho	6096	17	-	-	HYPH
cord-006229-7yoilsho	6096	18	time	time	NN
cord-006229-7yoilsho	6096	19	alternative	alternative	NN
cord-006229-7yoilsho	6096	20	to	to	IN
cord-006229-7yoilsho	6096	21	rodent	rodent	NN
cord-006229-7yoilsho	6096	22	bioassays	bioassay	NNS
cord-006229-7yoilsho	6096	23	.	.	.
cord-006229-7yoilsho	6097	1	Although	although	IN
cord-006229-7yoilsho	6097	2	this	this	DT
cord-006229-7yoilsho	6097	3	method	method	NN
cord-006229-7yoilsho	6097	4	does	do	VBZ
cord-006229-7yoilsho	6097	5	not	not	RB
cord-006229-7yoilsho	6097	6	mimic	mimic	VB
cord-006229-7yoilsho	6097	7	the	the	DT
cord-006229-7yoilsho	6097	8	whole	whole	NN
cord-006229-7yoilsho	6097	9	in	in	IN
cord-006229-7yoilsho	6097	10	vivo	vivo	JJ
cord-006229-7yoilsho	6097	11	neoplastic	neoplastic	JJ
cord-006229-7yoilsho	6097	12	process	process	NN
cord-006229-7yoilsho	6097	13	,	,	,
cord-006229-7yoilsho	6097	14	it	-PRON-	PRP
cord-006229-7yoilsho	6097	15	can	can	MD
cord-006229-7yoilsho	6097	16	be	be	VB
cord-006229-7yoilsho	6097	17	used	use	VBN
cord-006229-7yoilsho	6097	18	to	to	TO
cord-006229-7yoilsho	6097	19	provide	provide	VB
cord-006229-7yoilsho	6097	20	essential	essential	JJ
cord-006229-7yoilsho	6097	21	information	information	NN
cord-006229-7yoilsho	6097	22	regarding	regard	VBG
cord-006229-7yoilsho	6097	23	key	key	JJ
cord-006229-7yoilsho	6097	24	proteins	protein	NNS
cord-006229-7yoilsho	6097	25	and	and	CC
cord-006229-7yoilsho	6097	26	their	-PRON-	PRP$
cord-006229-7yoilsho	6097	27	signalling	signalling	NN
cord-006229-7yoilsho	6097	28	,	,	,
cord-006229-7yoilsho	6097	29	during	during	IN
cord-006229-7yoilsho	6097	30	the	the	DT
cord-006229-7yoilsho	6097	31	different	different	JJ
cord-006229-7yoilsho	6097	32	stages	stage	NNS
cord-006229-7yoilsho	6097	33	of	of	IN
cord-006229-7yoilsho	6097	34	transformation	transformation	NN
cord-006229-7yoilsho	6097	35	.	.	.
cord-006229-7yoilsho	6098	1	Is	be	VBZ
cord-006229-7yoilsho	6098	2	there	there	EX
cord-006229-7yoilsho	6098	3	hope	hope	NN
cord-006229-7yoilsho	6098	4	to	to	TO
cord-006229-7yoilsho	6098	5	correctly	correctly	RB
cord-006229-7yoilsho	6098	6	classify	classify	VB
cord-006229-7yoilsho	6098	7	severe	severe	JJ
cord-006229-7yoilsho	6098	8	ocular	ocular	JJ
cord-006229-7yoilsho	6098	9	irritant	irritant	JJ
cord-006229-7yoilsho	6098	10	agrochemical	agrochemical	JJ
cord-006229-7yoilsho	6098	11	formulations	formulation	NNS
cord-006229-7yoilsho	6098	12	using	use	VBG
cord-006229-7yoilsho	6098	13	in	in	IN
cord-006229-7yoilsho	6098	14	vitro	vitro	FW
cord-006229-7yoilsho	6098	15	methods	method	NNS
cord-006229-7yoilsho	6098	16	:	:	:
cord-006229-7yoilsho	6098	17	A	a	DT
cord-006229-7yoilsho	6098	18	proof	proof	NN
cord-006229-7yoilsho	6098	19	of	of	IN
cord-006229-7yoilsho	6098	20	concept	concept	NN
cord-006229-7yoilsho	6098	21	using	use	VBG
cord-006229-7yoilsho	6098	22	the	the	DT
cord-006229-7yoilsho	6098	23	Isolated	Isolated	NNP
cord-006229-7yoilsho	6098	24	Chicken	Chicken	NNP
cord-006229-7yoilsho	6098	25	Eye	Eye	NNP
cord-006229-7yoilsho	6098	26	Test	Test	NNP
cord-006229-7yoilsho	6098	27	,	,	,
cord-006229-7yoilsho	6098	28	two	two	CD
cord-006229-7yoilsho	6098	29	modified	modify	VBN
cord-006229-7yoilsho	6098	30	BCOP	BCOP	NNP
cord-006229-7yoilsho	6098	31	protocols	protocol	NNS
cord-006229-7yoilsho	6098	32	and	and	CC
cord-006229-7yoilsho	6098	33	an	an	DT
cord-006229-7yoilsho	6098	34	EpiOcular	EpiOcular	NNP
cord-006229-7yoilsho	6098	35	™	™	NN
cord-006229-7yoilsho	6098	36	ET50	ET50	NNP
cord-006229-7yoilsho	6098	37	protocol	protocol	NN
cord-006229-7yoilsho	6099	1	While	while	IN
cord-006229-7yoilsho	6099	2	some	some	DT
cord-006229-7yoilsho	6099	3	in	in	IN
cord-006229-7yoilsho	6099	4	vitro	vitro	FW
cord-006229-7yoilsho	6099	5	methods	method	NNS
cord-006229-7yoilsho	6099	6	addressing	address	VBG
cord-006229-7yoilsho	6099	7	ocular	ocular	JJ
cord-006229-7yoilsho	6099	8	irritancy	irritancy	NN
cord-006229-7yoilsho	6099	9	have	have	VBP
cord-006229-7yoilsho	6099	10	gained	gain	VBN
cord-006229-7yoilsho	6099	11	regulatory	regulatory	JJ
cord-006229-7yoilsho	6099	12	acceptance	acceptance	NN
cord-006229-7yoilsho	6099	13	,	,	,
cord-006229-7yoilsho	6099	14	to	to	IN
cord-006229-7yoilsho	6099	15	date	date	NN
cord-006229-7yoilsho	6099	16	the	the	DT
cord-006229-7yoilsho	6099	17	Draize	Draize	NNP
cord-006229-7yoilsho	6099	18	rabbit	rabbit	NN
cord-006229-7yoilsho	6099	19	eye	eye	NN
cord-006229-7yoilsho	6099	20	test	test	NN
cord-006229-7yoilsho	6099	21	(	(	-LRB-
cord-006229-7yoilsho	6099	22	OECD	OECD	NNP
cord-006229-7yoilsho	6099	23	TG	TG	NNP
cord-006229-7yoilsho	6099	24	405	405	CD
cord-006229-7yoilsho	6099	25	)	)	-RRB-
cord-006229-7yoilsho	6099	26	is	be	VBZ
cord-006229-7yoilsho	6099	27	the	the	DT
cord-006229-7yoilsho	6099	28	only	only	JJ
cord-006229-7yoilsho	6099	29	world	world	NN
cord-006229-7yoilsho	6099	30	-	-	HYPH
cord-006229-7yoilsho	6099	31	wide	wide	JJ
cord-006229-7yoilsho	6099	32	regulatory	regulatory	JJ
cord-006229-7yoilsho	6099	33	accepted	accept	VBN
cord-006229-7yoilsho	6099	34	test	test	NN
cord-006229-7yoilsho	6099	35	for	for	IN
cord-006229-7yoilsho	6099	36	the	the	DT
cord-006229-7yoilsho	6099	37	determination	determination	NN
cord-006229-7yoilsho	6099	38	of	of	IN
cord-006229-7yoilsho	6099	39	the	the	DT
cord-006229-7yoilsho	6099	40	full	full	JJ
cord-006229-7yoilsho	6099	41	range	range	NN
cord-006229-7yoilsho	6099	42	of	of	IN
cord-006229-7yoilsho	6099	43	eye	eye	NN
cord-006229-7yoilsho	6099	44	irritation	irritation	NN
cord-006229-7yoilsho	6099	45	potential	potential	NN
cord-006229-7yoilsho	6099	46	.	.	.
cord-006229-7yoilsho	6100	1	Further	further	RB
cord-006229-7yoilsho	6100	2	although	although	IN
cord-006229-7yoilsho	6100	3	several	several	JJ
cord-006229-7yoilsho	6100	4	in	in	IN
cord-006229-7yoilsho	6100	5	vitro	vitro	FW
cord-006229-7yoilsho	6100	6	methods	method	NNS
cord-006229-7yoilsho	6100	7	for	for	IN
cord-006229-7yoilsho	6100	8	the	the	DT
cord-006229-7yoilsho	6100	9	severe	severe	JJ
cord-006229-7yoilsho	6100	10	eye	eye	NN
cord-006229-7yoilsho	6100	11	irritation	irritation	NN
cord-006229-7yoilsho	6100	12	have	have	VBP
cord-006229-7yoilsho	6100	13	gained	gain	VBN
cord-006229-7yoilsho	6100	14	regulatory	regulatory	JJ
cord-006229-7yoilsho	6100	15	acceptance	acceptance	NN
cord-006229-7yoilsho	6100	16	,	,	,
cord-006229-7yoilsho	6100	17	agrochemical	agrochemical	JJ
cord-006229-7yoilsho	6100	18	formulations	formulation	NNS
cord-006229-7yoilsho	6100	19	are	be	VBP
cord-006229-7yoilsho	6100	20	nor	nor	CC
cord-006229-7yoilsho	6100	21	explicitly	explicitly	RB
cord-006229-7yoilsho	6100	22	included	include	VBN
cord-006229-7yoilsho	6100	23	nor	nor	CC
cord-006229-7yoilsho	6100	24	excluded	exclude	VBN
cord-006229-7yoilsho	6100	25	from	from	IN
cord-006229-7yoilsho	6100	26	the	the	DT
cord-006229-7yoilsho	6100	27	applicability	applicability	NN
cord-006229-7yoilsho	6100	28	domain	domain	NN
cord-006229-7yoilsho	6100	29	to	to	TO
cord-006229-7yoilsho	6100	30	predict	predict	VB
cord-006229-7yoilsho	6100	31	severe	severe	JJ
cord-006229-7yoilsho	6100	32	ocular	ocular	JJ
cord-006229-7yoilsho	6100	33	irritant	irritant	JJ
cord-006229-7yoilsho	6100	34	formulations	formulation	NNS
cord-006229-7yoilsho	6100	35	.	.	.
cord-006229-7yoilsho	6101	1	Systematic	systematic	JJ
cord-006229-7yoilsho	6101	2	analyses	analysis	NNS
cord-006229-7yoilsho	6101	3	are	be	VBP
cord-006229-7yoilsho	6101	4	only	only	RB
cord-006229-7yoilsho	6101	5	available	available	JJ
cord-006229-7yoilsho	6101	6	for	for	IN
cord-006229-7yoilsho	6101	7	e.g.	e.g.	RB
cord-006229-7yoilsho	6101	8	the	the	DT
cord-006229-7yoilsho	6101	9	hen	hen	NN
cord-006229-7yoilsho	6101	10	's	's	POS
cord-006229-7yoilsho	6101	11	egg	egg	NN
cord-006229-7yoilsho	6101	12	test	test	NN
cord-006229-7yoilsho	6101	13	-	-	HYPH
cord-006229-7yoilsho	6101	14	chorioallantoic	chorioallantoic	VBN
cord-006229-7yoilsho	6101	15	membrane	membrane	NN
cord-006229-7yoilsho	6101	16	(	(	-LRB-
cord-006229-7yoilsho	6101	17	HET	HET	NNP
cord-006229-7yoilsho	6101	18	-	-	HYPH
cord-006229-7yoilsho	6101	19	CAM	CAM	NNP
cord-006229-7yoilsho	6101	20	)	)	-RRB-
cord-006229-7yoilsho	6101	21	,	,	,
cord-006229-7yoilsho	6101	22	and	and	CC
cord-006229-7yoilsho	6101	23	bovine	bovine	JJ
cord-006229-7yoilsho	6101	24	corneal	corneal	JJ
cord-006229-7yoilsho	6101	25	opacity	opacity	NN
cord-006229-7yoilsho	6101	26	and	and	CC
cord-006229-7yoilsho	6101	27	permeability	permeability	NN
cord-006229-7yoilsho	6101	28	(	(	-LRB-
cord-006229-7yoilsho	6101	29	BCOP	BCOP	NNP
cord-006229-7yoilsho	6101	30	,	,	,
cord-006229-7yoilsho	6101	31	OECD	OECD	NNP
cord-006229-7yoilsho	6101	32	TG	TG	NNP
cord-006229-7yoilsho	6101	33	437	437	CD
cord-006229-7yoilsho	6101	34	)	)	-RRB-
cord-006229-7yoilsho	6101	35	assays	assay	NNS
cord-006229-7yoilsho	6101	36	both	both	DT
cord-006229-7yoilsho	6101	37	showing	show	VBG
cord-006229-7yoilsho	6101	38	that	that	IN
cord-006229-7yoilsho	6101	39	the	the	DT
cord-006229-7yoilsho	6101	40	used	use	VBN
cord-006229-7yoilsho	6101	41	protocols	protocol	NNS
cord-006229-7yoilsho	6101	42	do	do	VBP
cord-006229-7yoilsho	6101	43	not	not	RB
cord-006229-7yoilsho	6101	44	provide	provide	VB
cord-006229-7yoilsho	6101	45	sufficient	sufficient	JJ
cord-006229-7yoilsho	6101	46	sensitivity	sensitivity	NN
cord-006229-7yoilsho	6101	47	to	to	TO
cord-006229-7yoilsho	6101	48	reliably	reliably	RB
cord-006229-7yoilsho	6101	49	predict	predict	VB
cord-006229-7yoilsho	6101	50	severe	severe	JJ
cord-006229-7yoilsho	6101	51	ocular	ocular	JJ
cord-006229-7yoilsho	6101	52	irritating	irritating	JJ
cord-006229-7yoilsho	6101	53	formulations	formulation	NNS
cord-006229-7yoilsho	6101	54	.	.	.
cord-006229-7yoilsho	6102	1	The	the	DT
cord-006229-7yoilsho	6102	2	purpose	purpose	NN
cord-006229-7yoilsho	6102	3	of	of	IN
cord-006229-7yoilsho	6102	4	this	this	DT
cord-006229-7yoilsho	6102	5	study	study	NN
cord-006229-7yoilsho	6102	6	was	be	VBD
cord-006229-7yoilsho	6102	7	to	to	TO
cord-006229-7yoilsho	6102	8	evaluate	evaluate	VB
cord-006229-7yoilsho	6102	9	whether	whether	IN
cord-006229-7yoilsho	6102	10	the	the	DT
cord-006229-7yoilsho	6102	11	regulatory	regulatory	JJ
cord-006229-7yoilsho	6102	12	accepted	accept	VBN
cord-006229-7yoilsho	6102	13	isolated	isolated	JJ
cord-006229-7yoilsho	6102	14	chicken	chicken	NN
cord-006229-7yoilsho	6102	15	eye	eye	NN
cord-006229-7yoilsho	6102	16	(	(	-LRB-
cord-006229-7yoilsho	6102	17	ICE	ICE	NNP
cord-006229-7yoilsho	6102	18	,	,	,
cord-006229-7yoilsho	6102	19	OECD	OECD	NNP
cord-006229-7yoilsho	6102	20	TG	TG	NNP
cord-006229-7yoilsho	6102	21	438	438	CD
cord-006229-7yoilsho	6102	22	)	)	-RRB-
cord-006229-7yoilsho	6102	23	test	test	VBP
cord-006229-7yoilsho	6102	24	including	include	VBG
cord-006229-7yoilsho	6102	25	corneal	corneal	JJ
cord-006229-7yoilsho	6102	26	histopathology	histopathology	NN
cord-006229-7yoilsho	6102	27	(	(	-LRB-
cord-006229-7yoilsho	6102	28	as	as	IN
cord-006229-7yoilsho	6102	29	suggested	suggest	VBN
cord-006229-7yoilsho	6102	30	for	for	IN
cord-006229-7yoilsho	6102	31	evaluation	evaluation	NN
cord-006229-7yoilsho	6102	32	of	of	IN
cord-006229-7yoilsho	6102	33	the	the	DT
cord-006229-7yoilsho	6102	34	depth	depth	NN
cord-006229-7yoilsho	6102	35	of	of	IN
cord-006229-7yoilsho	6102	36	injury	injury	NN
cord-006229-7yoilsho	6102	37	)	)	-RRB-
cord-006229-7yoilsho	6102	38	,	,	,
cord-006229-7yoilsho	6102	39	as	as	RB
cord-006229-7yoilsho	6102	40	well	well	RB
cord-006229-7yoilsho	6102	41	two	two	CD
cord-006229-7yoilsho	6102	42	modified	modify	VBN
cord-006229-7yoilsho	6102	43	protocols	protocol	NNS
cord-006229-7yoilsho	6102	44	of	of	IN
cord-006229-7yoilsho	6102	45	the	the	DT
cord-006229-7yoilsho	6102	46	BCOP	BCOP	NNP
cord-006229-7yoilsho	6102	47	and/or	and/or	CC
cord-006229-7yoilsho	6102	48	an	an	DT
cord-006229-7yoilsho	6102	49	ET50	ET50	NNP
cord-006229-7yoilsho	6102	50	(	(	-LRB-
cord-006229-7yoilsho	6102	51	exposure	exposure	NN
cord-006229-7yoilsho	6102	52	time	time	NN
cord-006229-7yoilsho	6102	53	reducing	reduce	VBG
cord-006229-7yoilsho	6102	54	viability	viability	NN
cord-006229-7yoilsho	6102	55	of	of	IN
cord-006229-7yoilsho	6102	56	treated	treat	VBN
cord-006229-7yoilsho	6102	57	tissue	tissue	NN
cord-006229-7yoilsho	6102	58	to	to	IN
cord-006229-7yoilsho	6102	59	50	50	CD
cord-006229-7yoilsho	6102	60	%	%	NN
cord-006229-7yoilsho	6102	61	)	)	-RRB-
cord-006229-7yoilsho	6102	62	protocol	protocol	NN
cord-006229-7yoilsho	6102	63	using	use	VBG
cord-006229-7yoilsho	6102	64	the	the	DT
cord-006229-7yoilsho	6102	65	reconstructed	reconstruct	VBN
cord-006229-7yoilsho	6102	66	cornea	cornea	NN
cord-006229-7yoilsho	6102	67	model	model	NN
cord-006229-7yoilsho	6102	68	EpiOcular	EpiOcular	NNP
cord-006229-7yoilsho	6102	69	™	™	NN
cord-006229-7yoilsho	6102	70	are	be	VBP
cord-006229-7yoilsho	6102	71	useful	useful	JJ
cord-006229-7yoilsho	6102	72	to	to	TO
cord-006229-7yoilsho	6102	73	predict	predict	VB
cord-006229-7yoilsho	6102	74	severe	severe	JJ
cord-006229-7yoilsho	6102	75	ocular	ocular	JJ
cord-006229-7yoilsho	6102	76	irritant	irritant	JJ
cord-006229-7yoilsho	6102	77	agrochemical	agrochemical	NN
cord-006229-7yoilsho	6102	78	formulations	formulation	NNS
cord-006229-7yoilsho	6102	79	.	.	.
cord-006229-7yoilsho	6103	1	A	a	DT
cord-006229-7yoilsho	6103	2	proof	proof	NN
cord-006229-7yoilsho	6103	3	of	of	IN
cord-006229-7yoilsho	6103	4	concept	concept	NN
cord-006229-7yoilsho	6103	5	comprising	comprise	VBG
cord-006229-7yoilsho	6103	6	the	the	DT
cord-006229-7yoilsho	6103	7	testing	testing	NN
cord-006229-7yoilsho	6103	8	of	of	IN
cord-006229-7yoilsho	6103	9	ten	ten	CD
cord-006229-7yoilsho	6103	10	to	to	TO
cord-006229-7yoilsho	6103	11	twelve	twelve	CD
cord-006229-7yoilsho	6103	12	agrochemical	agrochemical	JJ
cord-006229-7yoilsho	6103	13	formulations	formulation	NNS
cord-006229-7yoilsho	6103	14	with	with	IN
cord-006229-7yoilsho	6103	15	available	available	JJ
cord-006229-7yoilsho	6103	16	in	in	IN
cord-006229-7yoilsho	6103	17	vivo	vivo	NN
cord-006229-7yoilsho	6103	18	data	datum	NNS
cord-006229-7yoilsho	6103	19	in	in	IN
cord-006229-7yoilsho	6103	20	each	each	DT
cord-006229-7yoilsho	6103	21	assay	assay	NN
cord-006229-7yoilsho	6103	22	was	be	VBD
cord-006229-7yoilsho	6103	23	conducted	conduct	VBN
cord-006229-7yoilsho	6103	24	.	.	.
cord-006229-7yoilsho	6104	1	In	in	IN
cord-006229-7yoilsho	6104	2	summary	summary	NN
cord-006229-7yoilsho	6104	3	,	,	,
cord-006229-7yoilsho	6104	4	based	base	VBN
cord-006229-7yoilsho	6104	5	on	on	IN
cord-006229-7yoilsho	6104	6	the	the	DT
cord-006229-7yoilsho	6104	7	ICE	ice	NN
cord-006229-7yoilsho	6104	8	evaluation	evaluation	NN
cord-006229-7yoilsho	6104	9	described	describe	VBN
cord-006229-7yoilsho	6104	10	in	in	IN
cord-006229-7yoilsho	6104	11	OECD	OECD	NNP
cord-006229-7yoilsho	6104	12	TG	TG	NNP
cord-006229-7yoilsho	6104	13	438	438	CD
cord-006229-7yoilsho	6104	14	,	,	,
cord-006229-7yoilsho	6104	15	one	one	CD
cord-006229-7yoilsho	6104	16	of	of	IN
cord-006229-7yoilsho	6104	17	the	the	DT
cord-006229-7yoilsho	6104	18	five	five	CD
cord-006229-7yoilsho	6104	19	severe	severe	JJ
cord-006229-7yoilsho	6104	20	ocular	ocular	JJ
cord-006229-7yoilsho	6104	21	irritant	irritant	JJ
cord-006229-7yoilsho	6104	22	formulations	formulation	NNS
cord-006229-7yoilsho	6104	23	(	(	-LRB-
cord-006229-7yoilsho	6104	24	UN	UN	NNP
cord-006229-7yoilsho	6104	25	GHS	GHS	NNP
cord-006229-7yoilsho	6104	26	Cat	Cat	NNP
cord-006229-7yoilsho	6104	27	1	1	CD
cord-006229-7yoilsho	6104	28	)	)	-RRB-
cord-006229-7yoilsho	6104	29	was	be	VBD
cord-006229-7yoilsho	6104	30	predicted	predict	VBN
cord-006229-7yoilsho	6104	31	correctly	correctly	RB
cord-006229-7yoilsho	6104	32	.	.	.
cord-006229-7yoilsho	6105	1	Using	use	VBG
cord-006229-7yoilsho	6105	2	both	both	DT
cord-006229-7yoilsho	6105	3	modified	modify	VBN
cord-006229-7yoilsho	6105	4	protocol	protocol	NN
cord-006229-7yoilsho	6105	5	versions	version	NNS
cord-006229-7yoilsho	6105	6	of	of	IN
cord-006229-7yoilsho	6105	7	the	the	DT
cord-006229-7yoilsho	6105	8	BCOP	BCOP	NNP
cord-006229-7yoilsho	6105	9	the	the	DT
cord-006229-7yoilsho	6105	10	result	result	NN
cord-006229-7yoilsho	6105	11	for	for	IN
cord-006229-7yoilsho	6105	12	one	one	CD
cord-006229-7yoilsho	6105	13	of	of	IN
cord-006229-7yoilsho	6105	14	the	the	DT
cord-006229-7yoilsho	6105	15	four	four	CD
cord-006229-7yoilsho	6105	16	tested	test	VBN
cord-006229-7yoilsho	6105	17	UN	UN	NNP
cord-006229-7yoilsho	6105	18	GHS	GHS	NNP
cord-006229-7yoilsho	6105	19	Cat	Cat	NNP
cord-006229-7yoilsho	6105	20	1	1	CD
cord-006229-7yoilsho	6105	21	formulations	formulation	NNS
cord-006229-7yoilsho	6105	22	was	be	VBD
cord-006229-7yoilsho	6105	23	just	just	RB
cord-006229-7yoilsho	6105	24	above	above	IN
cord-006229-7yoilsho	6105	25	the	the	DT
cord-006229-7yoilsho	6105	26	UN	UN	NNP
cord-006229-7yoilsho	6105	27	GHS	GHS	NNP
cord-006229-7yoilsho	6105	28	Cat	Cat	NNP
cord-006229-7yoilsho	6105	29	1	1	CD
cord-006229-7yoilsho	6105	30	classification	classification	NN
cord-006229-7yoilsho	6105	31	border	border	NN
cord-006229-7yoilsho	6105	32	for	for	IN
cord-006229-7yoilsho	6105	33	using	use	VBG
cord-006229-7yoilsho	6105	34	one	one	CD
cord-006229-7yoilsho	6105	35	of	of	IN
cord-006229-7yoilsho	6105	36	the	the	DT
cord-006229-7yoilsho	6105	37	modified	modify	VBN
cord-006229-7yoilsho	6105	38	protocols	protocol	NNS
cord-006229-7yoilsho	6105	39	.	.	.
cord-006229-7yoilsho	6106	1	Lastly	lastly	RB
cord-006229-7yoilsho	6106	2	and	and	CC
cord-006229-7yoilsho	6106	3	most	most	RBS
cord-006229-7yoilsho	6106	4	promising	promising	JJ
cord-006229-7yoilsho	6106	5	,	,	,
cord-006229-7yoilsho	6106	6	the	the	DT
cord-006229-7yoilsho	6106	7	EpiOcular	EpiOcular	NNP
cord-006229-7yoilsho	6106	8	™	™	NN
cord-006229-7yoilsho	6106	9	ET50	ET50	NNP
cord-006229-7yoilsho	6106	10	predicted	predict	VBD
cord-006229-7yoilsho	6106	11	four	four	CD
cord-006229-7yoilsho	6106	12	of	of	IN
cord-006229-7yoilsho	6106	13	five	five	CD
cord-006229-7yoilsho	6106	14	tested	test	VBN
cord-006229-7yoilsho	6106	15	UN	UN	NNP
cord-006229-7yoilsho	6106	16	GHS	GHS	NNP
cord-006229-7yoilsho	6106	17	formulations	formulation	NNS
cord-006229-7yoilsho	6106	18	correctly	correctly	RB
cord-006229-7yoilsho	6106	19	with	with	IN
cord-006229-7yoilsho	6106	20	the	the	DT
cord-006229-7yoilsho	6106	21	fifths	fifth	NNS
cord-006229-7yoilsho	6106	22	being	be	VBG
cord-006229-7yoilsho	6106	23	close	close	JJ
cord-006229-7yoilsho	6106	24	to	to	IN
cord-006229-7yoilsho	6106	25	the	the	DT
cord-006229-7yoilsho	6106	26	classification	classification	NN
cord-006229-7yoilsho	6106	27	border	border	NN
cord-006229-7yoilsho	6106	28	.	.	.
cord-006229-7yoilsho	6107	1	Additional	additional	JJ
cord-006229-7yoilsho	6107	2	agrochemical	agrochemical	JJ
cord-006229-7yoilsho	6107	3	formulations	formulation	NNS
cord-006229-7yoilsho	6107	4	will	will	MD
cord-006229-7yoilsho	6107	5	be	be	VB
cord-006229-7yoilsho	6107	6	tested	test	VBN
cord-006229-7yoilsho	6107	7	to	to	IN
cord-006229-7yoilsho	6107	8	further	further	RB
cord-006229-7yoilsho	6107	9	evaluated	evaluate	VBN
cord-006229-7yoilsho	6107	10	the	the	DT
cord-006229-7yoilsho	6107	11	EpiOcular	EpiOcular	NNP
cord-006229-7yoilsho	6107	12	™	™	NN
cord-006229-7yoilsho	6107	13	ET50	ET50	NNP
cord-006229-7yoilsho	6107	14	protocol	protocol	NN
cord-006229-7yoilsho	6107	15	to	to	TO
cord-006229-7yoilsho	6107	16	identify	identify	VB
cord-006229-7yoilsho	6107	17	severe	severe	JJ
cord-006229-7yoilsho	6107	18	ocular	ocular	JJ
cord-006229-7yoilsho	6107	19	irritant	irritant	JJ
cord-006229-7yoilsho	6107	20	agrochemical	agrochemical	NN
cord-006229-7yoilsho	6107	21	formulations	formulation	NNS
cord-006229-7yoilsho	6107	22	.	.	.
cord-006229-7yoilsho	6108	1	Drug	drug	NN
cord-006229-7yoilsho	6108	2	-	-	HYPH
cord-006229-7yoilsho	6108	3	induced	induce	VBN
cord-006229-7yoilsho	6108	4	pancreatic	pancreatic	JJ
cord-006229-7yoilsho	6108	5	toxicity	toxicity	NN
cord-006229-7yoilsho	6108	6	comprises	comprise	VBZ
cord-006229-7yoilsho	6108	7	effects	effect	NNS
cord-006229-7yoilsho	6108	8	on	on	IN
cord-006229-7yoilsho	6108	9	the	the	DT
cord-006229-7yoilsho	6108	10	exocrine	exocrine	NN
cord-006229-7yoilsho	6108	11	and/or	and/or	CC
cord-006229-7yoilsho	6108	12	the	the	DT
cord-006229-7yoilsho	6108	13	endocrine	endocrine	JJ
cord-006229-7yoilsho	6108	14	pancreas	pancrea	NNS
cord-006229-7yoilsho	6108	15	,	,	,
cord-006229-7yoilsho	6108	16	which	which	WDT
cord-006229-7yoilsho	6108	17	both	both	DT
cord-006229-7yoilsho	6108	18	can	can	MD
cord-006229-7yoilsho	6108	19	have	have	VB
cord-006229-7yoilsho	6108	20	serious	serious	JJ
cord-006229-7yoilsho	6108	21	clinical	clinical	JJ
cord-006229-7yoilsho	6108	22	implications	implication	NNS
cord-006229-7yoilsho	6108	23	,	,	,
cord-006229-7yoilsho	6108	24	e.g.	e.g.	IN
cord-006229-7yoilsho	6108	25	acute	acute	JJ
cord-006229-7yoilsho	6108	26	pancreatitis	pancreatitis	NN
cord-006229-7yoilsho	6108	27	or	or	CC
cord-006229-7yoilsho	6108	28	diabetes	diabetes	NN
cord-006229-7yoilsho	6108	29	mellitus	mellitus	NN
cord-006229-7yoilsho	6108	30	.	.	.
cord-006229-7yoilsho	6109	1	Adverse	adverse	JJ
cord-006229-7yoilsho	6109	2	effects	effect	NNS
cord-006229-7yoilsho	6109	3	on	on	IN
cord-006229-7yoilsho	6109	4	the	the	DT
cord-006229-7yoilsho	6109	5	pancreas	pancrea	NNS
cord-006229-7yoilsho	6109	6	are	be	VBP
cord-006229-7yoilsho	6109	7	occasionally	occasionally	RB
cord-006229-7yoilsho	6109	8	observed	observe	VBN
cord-006229-7yoilsho	6109	9	during	during	IN
cord-006229-7yoilsho	6109	10	drug	drug	NN
cord-006229-7yoilsho	6109	11	discovery	discovery	NN
cord-006229-7yoilsho	6109	12	and	and	CC
cord-006229-7yoilsho	6109	13	development	development	NN
cord-006229-7yoilsho	6109	14	and	and	CC
cord-006229-7yoilsho	6109	15	often	often	RB
cord-006229-7yoilsho	6109	16	prohibit	prohibit	VBP
cord-006229-7yoilsho	6109	17	further	further	JJ
cord-006229-7yoilsho	6109	18	development	development	NN
cord-006229-7yoilsho	6109	19	.	.	.
cord-006229-7yoilsho	6110	1	Hence	hence	RB
cord-006229-7yoilsho	6110	2	,	,	,
cord-006229-7yoilsho	6110	3	there	there	EX
cord-006229-7yoilsho	6110	4	is	be	VBZ
cord-006229-7yoilsho	6110	5	a	a	DT
cord-006229-7yoilsho	6110	6	need	need	NN
cord-006229-7yoilsho	6110	7	for	for	IN
cord-006229-7yoilsho	6110	8	reliable	reliable	JJ
cord-006229-7yoilsho	6110	9	in	in	IN
cord-006229-7yoilsho	6110	10	vitro	vitro	FW
cord-006229-7yoilsho	6110	11	models	model	NNS
cord-006229-7yoilsho	6110	12	to	to	TO
cord-006229-7yoilsho	6110	13	early	early	RB
cord-006229-7yoilsho	6110	14	on	on	RB
cord-006229-7yoilsho	6110	15	identify	identify	VB
cord-006229-7yoilsho	6110	16	the	the	DT
cord-006229-7yoilsho	6110	17	pancreas	pancreas	NN
cord-006229-7yoilsho	6110	18	-	-	HYPH
cord-006229-7yoilsho	6110	19	toxic	toxic	JJ
cord-006229-7yoilsho	6110	20	potential	potential	NN
cord-006229-7yoilsho	6110	21	of	of	IN
cord-006229-7yoilsho	6110	22	drug	drug	NN
cord-006229-7yoilsho	6110	23	candidates	candidate	NNS
cord-006229-7yoilsho	6110	24	.	.	.
cord-006229-7yoilsho	6111	1	Permanent	permanent	JJ
cord-006229-7yoilsho	6111	2	cell	cell	NN
cord-006229-7yoilsho	6111	3	lines	line	NNS
cord-006229-7yoilsho	6111	4	and	and	CC
cord-006229-7yoilsho	6111	5	primary	primary	JJ
cord-006229-7yoilsho	6111	6	cells	cell	NNS
cord-006229-7yoilsho	6111	7	have	have	VBP
cord-006229-7yoilsho	6111	8	many	many	JJ
cord-006229-7yoilsho	6111	9	shortcomings	shortcoming	NNS
cord-006229-7yoilsho	6111	10	,	,	,
cord-006229-7yoilsho	6111	11	e.g.	e.g.	RB
cord-006229-7yoilsho	6111	12	loss	loss	NN
cord-006229-7yoilsho	6111	13	of	of	IN
cord-006229-7yoilsho	6111	14	cell	cell	NN
cord-006229-7yoilsho	6111	15	-	-	HYPH
cord-006229-7yoilsho	6111	16	to	to	IN
cord-006229-7yoilsho	6111	17	-	-	HYPH
cord-006229-7yoilsho	6111	18	cell	cell	NN
cord-006229-7yoilsho	6111	19	and	and	CC
cord-006229-7yoilsho	6111	20	cell	cell	NN
cord-006229-7yoilsho	6111	21	-	-	HYPH
cord-006229-7yoilsho	6111	22	to	to	IN
cord-006229-7yoilsho	6111	23	-	-	HYPH
cord-006229-7yoilsho	6111	24	matrix	matrix	NN
cord-006229-7yoilsho	6111	25	relationships	relationship	NNS
cord-006229-7yoilsho	6111	26	or	or	CC
cord-006229-7yoilsho	6111	27	changes	change	NNS
cord-006229-7yoilsho	6111	28	in	in	IN
cord-006229-7yoilsho	6111	29	cell	cell	NN
cord-006229-7yoilsho	6111	30	physiology	physiology	NN
cord-006229-7yoilsho	6111	31	due	due	IN
cord-006229-7yoilsho	6111	32	to	to	IN
cord-006229-7yoilsho	6111	33	the	the	DT
cord-006229-7yoilsho	6111	34	isolation	isolation	NN
cord-006229-7yoilsho	6111	35	procedure	procedure	NN
cord-006229-7yoilsho	6111	36	.	.	.
cord-006229-7yoilsho	6112	1	Pancreas	pancreas	NN
cord-006229-7yoilsho	6112	2	tissue	tissue	NN
cord-006229-7yoilsho	6112	3	slices	slice	NNS
cord-006229-7yoilsho	6112	4	are	be	VBP
cord-006229-7yoilsho	6112	5	a	a	DT
cord-006229-7yoilsho	6112	6	potential	potential	JJ
cord-006229-7yoilsho	6112	7	alternative	alternative	NN
cord-006229-7yoilsho	6112	8	,	,	,
cord-006229-7yoilsho	6112	9	circumventing	circumvent	VBG
cord-006229-7yoilsho	6112	10	most	most	JJS
cord-006229-7yoilsho	6112	11	of	of	IN
cord-006229-7yoilsho	6112	12	these	these	DT
cord-006229-7yoilsho	6112	13	limitations	limitation	NNS
cord-006229-7yoilsho	6112	14	.	.	.
cord-006229-7yoilsho	6113	1	Their	-PRON-	PRP$
cord-006229-7yoilsho	6113	2	preparation	preparation	NN
cord-006229-7yoilsho	6113	3	is	be	VBZ
cord-006229-7yoilsho	6113	4	rather	rather	RB
cord-006229-7yoilsho	6113	5	elaborate	elaborate	JJ
cord-006229-7yoilsho	6113	6	which	which	WDT
cord-006229-7yoilsho	6113	7	may	may	MD
cord-006229-7yoilsho	6113	8	explain	explain	VB
cord-006229-7yoilsho	6113	9	its	-PRON-	PRP$
cord-006229-7yoilsho	6113	10	rare	rare	JJ
cord-006229-7yoilsho	6113	11	use	use	NN
cord-006229-7yoilsho	6113	12	.	.	.
cord-006229-7yoilsho	6114	1	So	so	RB
cord-006229-7yoilsho	6114	2	far	far	RB
cord-006229-7yoilsho	6114	3	,	,	,
cord-006229-7yoilsho	6114	4	pancreas	pancreas	NN
cord-006229-7yoilsho	6114	5	tissue	tissue	NN
cord-006229-7yoilsho	6114	6	slices	slice	NNS
cord-006229-7yoilsho	6114	7	have	have	VBP
cord-006229-7yoilsho	6114	8	predominantly	predominantly	RB
cord-006229-7yoilsho	6114	9	been	be	VBN
cord-006229-7yoilsho	6114	10	used	use	VBN
cord-006229-7yoilsho	6114	11	to	to	TO
cord-006229-7yoilsho	6114	12	address	address	VB
cord-006229-7yoilsho	6114	13	physiological	physiological	JJ
cord-006229-7yoilsho	6114	14	or	or	CC
cord-006229-7yoilsho	6114	15	pharmacological	pharmacological	JJ
cord-006229-7yoilsho	6114	16	questions	question	NNS
cord-006229-7yoilsho	6114	17	,	,	,
cord-006229-7yoilsho	6114	18	although	although	IN
cord-006229-7yoilsho	6114	19	they	-PRON-	PRP
cord-006229-7yoilsho	6114	20	might	may	MD
cord-006229-7yoilsho	6114	21	also	also	RB
cord-006229-7yoilsho	6114	22	serve	serve	VB
cord-006229-7yoilsho	6114	23	as	as	RB
cord-006229-7yoilsho	6114	24	valuable	valuable	JJ
cord-006229-7yoilsho	6114	25	in	in	FW
cord-006229-7yoilsho	6114	26	vitro	vitro	FW
cord-006229-7yoilsho	6114	27	model	model	NN
cord-006229-7yoilsho	6114	28	for	for	IN
cord-006229-7yoilsho	6114	29	toxicological	toxicological	JJ
cord-006229-7yoilsho	6114	30	applications	application	NNS
cord-006229-7yoilsho	6114	31	.	.	.
cord-006229-7yoilsho	6115	1	Therefore	therefore	RB
cord-006229-7yoilsho	6115	2	,	,	,
cord-006229-7yoilsho	6115	3	this	this	DT
cord-006229-7yoilsho	6115	4	work	work	NN
cord-006229-7yoilsho	6115	5	aimed	aim	VBN
cord-006229-7yoilsho	6115	6	to	to	TO
cord-006229-7yoilsho	6115	7	establish	establish	VB
cord-006229-7yoilsho	6115	8	and	and	CC
cord-006229-7yoilsho	6115	9	characterize	characterize	VB
cord-006229-7yoilsho	6115	10	rat	rat	NN
cord-006229-7yoilsho	6115	11	pancreas	pancreas	NN
cord-006229-7yoilsho	6115	12	tissue	tissue	NN
cord-006229-7yoilsho	6115	13	slices	slice	NNS
cord-006229-7yoilsho	6115	14	as	as	IN
cord-006229-7yoilsho	6115	15	in	in	IN
cord-006229-7yoilsho	6115	16	vitro	vitro	FW
cord-006229-7yoilsho	6115	17	model	model	NN
cord-006229-7yoilsho	6115	18	for	for	IN
cord-006229-7yoilsho	6115	19	studying	study	VBG
cord-006229-7yoilsho	6115	20	drug	drug	NN
cord-006229-7yoilsho	6115	21	-	-	HYPH
cord-006229-7yoilsho	6115	22	induced	induce	VBN
cord-006229-7yoilsho	6115	23	pancreatic	pancreatic	JJ
cord-006229-7yoilsho	6115	24	toxicity	toxicity	NN
cord-006229-7yoilsho	6115	25	.	.	.
cord-006229-7yoilsho	6116	1	Results	result	NNS
cord-006229-7yoilsho	6116	2	will	will	MD
cord-006229-7yoilsho	6116	3	be	be	VB
cord-006229-7yoilsho	6116	4	compared	compare	VBN
cord-006229-7yoilsho	6116	5	to	to	IN
cord-006229-7yoilsho	6116	6	the	the	DT
cord-006229-7yoilsho	6116	7	responses	response	NNS
cord-006229-7yoilsho	6116	8	of	of	IN
cord-006229-7yoilsho	6116	9	the	the	DT
cord-006229-7yoilsho	6116	10	permanent	permanent	JJ
cord-006229-7yoilsho	6116	11	endocrine	endocrine	NN
cord-006229-7yoilsho	6116	12	(	(	-LRB-
cord-006229-7yoilsho	6116	13	INS-1E	INS-1E	NNP
cord-006229-7yoilsho	6116	14	)	)	-RRB-
cord-006229-7yoilsho	6116	15	and	and	CC
cord-006229-7yoilsho	6116	16	exocrine	exocrine	JJ
cord-006229-7yoilsho	6116	17	(	(	-LRB-
cord-006229-7yoilsho	6116	18	AR42J	ar42j	NN
cord-006229-7yoilsho	6116	19	)	)	-RRB-
cord-006229-7yoilsho	6116	20	pancreatic	pancreatic	JJ
cord-006229-7yoilsho	6116	21	cell	cell	NN
cord-006229-7yoilsho	6116	22	lines	line	NNS
cord-006229-7yoilsho	6116	23	to	to	TO
cord-006229-7yoilsho	6116	24	evaluate	evaluate	VB
cord-006229-7yoilsho	6116	25	a	a	DT
cord-006229-7yoilsho	6116	26	potential	potential	JJ
cord-006229-7yoilsho	6116	27	added	add	VBN
cord-006229-7yoilsho	6116	28	value	value	NN
cord-006229-7yoilsho	6116	29	.	.	.
cord-006229-7yoilsho	6117	1	Rat	rat	NN
cord-006229-7yoilsho	6117	2	pancreas	pancrea	VBZ
cord-006229-7yoilsho	6117	3	tissue	tissue	NN
cord-006229-7yoilsho	6117	4	slices	slice	NNS
cord-006229-7yoilsho	6117	5	were	be	VBD
cord-006229-7yoilsho	6117	6	prepared	prepare	VBN
cord-006229-7yoilsho	6117	7	by	by	IN
cord-006229-7yoilsho	6117	8	a	a	DT
cord-006229-7yoilsho	6117	9	protocol	protocol	NN
cord-006229-7yoilsho	6117	10	adapted	adapt	VBN
cord-006229-7yoilsho	6117	11	from	from	IN
cord-006229-7yoilsho	6117	12	Marciniak	Marciniak	NNP
cord-006229-7yoilsho	6117	13	et	et	NNP
cord-006229-7yoilsho	6117	14	al	al	NNP
cord-006229-7yoilsho	6117	15	.	.	.
cord-006229-7yoilsho	6118	1	(	(	-LRB-
cord-006229-7yoilsho	6118	2	Nat	Nat	NNP
cord-006229-7yoilsho	6118	3	Protoc	Protoc	NNP
cord-006229-7yoilsho	6118	4	,	,	,
cord-006229-7yoilsho	6118	5	2014	2014	CD
cord-006229-7yoilsho	6118	6	.	.	.
cord-006229-7yoilsho	6119	1	9(12	9(12	CD
cord-006229-7yoilsho	6119	2	)	)	-RRB-
cord-006229-7yoilsho	6119	3	:	:	:
cord-006229-7yoilsho	6120	1	p.	p.	NN
cord-006229-7yoilsho	6120	2	2809	2809	CD
cord-006229-7yoilsho	6120	3	.	.	.
cord-006229-7yoilsho	6121	1	Briefly	briefly	RB
cord-006229-7yoilsho	6121	2	,	,	,
cord-006229-7yoilsho	6121	3	pancreas	pancreas	NN
cord-006229-7yoilsho	6121	4	was	be	VBD
cord-006229-7yoilsho	6121	5	infused	infuse	VBN
cord-006229-7yoilsho	6121	6	and	and	CC
cord-006229-7yoilsho	6121	7	embedded	embed	VBN
cord-006229-7yoilsho	6121	8	with	with	IN
cord-006229-7yoilsho	6121	9	agarose	agarose	NN
cord-006229-7yoilsho	6121	10	.	.	.
cord-006229-7yoilsho	6122	1	Tissue	tissue	NN
cord-006229-7yoilsho	6122	2	sections	section	NNS
cord-006229-7yoilsho	6122	3	of	of	IN
cord-006229-7yoilsho	6122	4	app	app	NN
cord-006229-7yoilsho	6122	5	.	.	.
cord-006229-7yoilsho	6123	1	200	200	CD
cord-006229-7yoilsho	6123	2	µm	µm	CD
cord-006229-7yoilsho	6123	3	were	be	VBD
cord-006229-7yoilsho	6123	4	prepared	prepare	VBN
cord-006229-7yoilsho	6123	5	using	use	VBG
cord-006229-7yoilsho	6123	6	a	a	DT
cord-006229-7yoilsho	6123	7	vibratome	vibratome	NN
cord-006229-7yoilsho	6123	8	and	and	CC
cord-006229-7yoilsho	6123	9	maintained	maintain	VBN
cord-006229-7yoilsho	6123	10	in	in	IN
cord-006229-7yoilsho	6123	11	cell	cell	NN
cord-006229-7yoilsho	6123	12	culture	culture	NN
cord-006229-7yoilsho	6123	13	medium	medium	NN
cord-006229-7yoilsho	6123	14	for	for	IN
cord-006229-7yoilsho	6123	15	up	up	IN
cord-006229-7yoilsho	6123	16	to	to	TO
cord-006229-7yoilsho	6123	17	6	6	CD
cord-006229-7yoilsho	6123	18	days	day	NNS
cord-006229-7yoilsho	6123	19	.	.	.
cord-006229-7yoilsho	6124	1	Cell	cell	NN
cord-006229-7yoilsho	6124	2	viability	viability	NN
cord-006229-7yoilsho	6124	3	was	be	VBD
cord-006229-7yoilsho	6124	4	determined	determine	VBN
cord-006229-7yoilsho	6124	5	by	by	IN
cord-006229-7yoilsho	6124	6	daily	daily	JJ
cord-006229-7yoilsho	6124	7	measurement	measurement	NN
cord-006229-7yoilsho	6124	8	of	of	IN
cord-006229-7yoilsho	6124	9	lactate	lactate	NN
cord-006229-7yoilsho	6124	10	dehydrogenase	dehydrogenase	NN
cord-006229-7yoilsho	6124	11	(	(	-LRB-
cord-006229-7yoilsho	6124	12	LDH	LDH	NNP
cord-006229-7yoilsho	6124	13	)	)	-RRB-
cord-006229-7yoilsho	6124	14	in	in	IN
cord-006229-7yoilsho	6124	15	medium	medium	JJ
cord-006229-7yoilsho	6124	16	supernatants	supernatant	NNS
cord-006229-7yoilsho	6124	17	and	and	CC
cord-006229-7yoilsho	6124	18	by	by	IN
cord-006229-7yoilsho	6124	19	microscopic	microscopic	JJ
cord-006229-7yoilsho	6124	20	evaluation	evaluation	NN
cord-006229-7yoilsho	6124	21	following	follow	VBG
cord-006229-7yoilsho	6124	22	fixation	fixation	NN
cord-006229-7yoilsho	6124	23	in	in	IN
cord-006229-7yoilsho	6124	24	10	10	CD
cord-006229-7yoilsho	6124	25	%	%	NN
cord-006229-7yoilsho	6124	26	formalin	formalin	NN
cord-006229-7yoilsho	6124	27	and	and	CC
cord-006229-7yoilsho	6124	28	H&E	H&E	NNP
cord-006229-7yoilsho	6124	29	staining	stain	VBG
cord-006229-7yoilsho	6124	30	.	.	.
cord-006229-7yoilsho	6125	1	Functional	functional	JJ
cord-006229-7yoilsho	6125	2	integrity	integrity	NN
cord-006229-7yoilsho	6125	3	of	of	IN
cord-006229-7yoilsho	6125	4	acinar	acinar	NNP
cord-006229-7yoilsho	6125	5	and	and	CC
cord-006229-7yoilsho	6126	1	beta	beta	NN
cord-006229-7yoilsho	6126	2	cells	cell	NNS
cord-006229-7yoilsho	6126	3	were	be	VBD
cord-006229-7yoilsho	6126	4	assessed	assess	VBN
cord-006229-7yoilsho	6126	5	by	by	IN
cord-006229-7yoilsho	6126	6	cell	cell	NN
cord-006229-7yoilsho	6126	7	-	-	HYPH
cord-006229-7yoilsho	6126	8	type	type	NN
cord-006229-7yoilsho	6126	9	specific	specific	JJ
cord-006229-7yoilsho	6126	10	secretory	secretory	JJ
cord-006229-7yoilsho	6126	11	responses	response	NNS
cord-006229-7yoilsho	6126	12	(	(	-LRB-
cord-006229-7yoilsho	6126	13	i.e.	i.e.	FW
cord-006229-7yoilsho	6126	14	insulin	insulin	NN
cord-006229-7yoilsho	6126	15	,	,	,
cord-006229-7yoilsho	6126	16	amylase	amylase	NN
cord-006229-7yoilsho	6126	17	,	,	,
cord-006229-7yoilsho	6126	18	lipase	lipase	NN
cord-006229-7yoilsho	6126	19	)	)	-RRB-
cord-006229-7yoilsho	6126	20	to	to	IN
cord-006229-7yoilsho	6126	21	physiological	physiological	JJ
cord-006229-7yoilsho	6126	22	stimuli	stimulus	NNS
cord-006229-7yoilsho	6126	23	.	.	.
cord-006229-7yoilsho	6127	1	Moreover	moreover	RB
cord-006229-7yoilsho	6127	2	,	,	,
cord-006229-7yoilsho	6127	3	the	the	DT
cord-006229-7yoilsho	6127	4	effects	effect	NNS
cord-006229-7yoilsho	6127	5	of	of	IN
cord-006229-7yoilsho	6127	6	the	the	DT
cord-006229-7yoilsho	6127	7	pancreas	pancreas	NN
cord-006229-7yoilsho	6127	8	toxins	toxin	NNS
cord-006229-7yoilsho	6127	9	streptozotocin	streptozotocin	NNP
cord-006229-7yoilsho	6127	10	(	(	-LRB-
cord-006229-7yoilsho	6127	11	STZ	STZ	NNP
cord-006229-7yoilsho	6127	12	)	)	-RRB-
cord-006229-7yoilsho	6127	13	,	,	,
cord-006229-7yoilsho	6127	14	alloxan	alloxan	NNP
cord-006229-7yoilsho	6127	15	(	(	-LRB-
cord-006229-7yoilsho	6127	16	ALL	all	DT
cord-006229-7yoilsho	6127	17	)	)	-RRB-
cord-006229-7yoilsho	6127	18	,	,	,
cord-006229-7yoilsho	6127	19	and	and	CC
cord-006229-7yoilsho	6127	20	the	the	DT
cord-006229-7yoilsho	6127	21	cholecystokinin	cholecystokinin	NN
cord-006229-7yoilsho	6127	22	(	(	-LRB-
cord-006229-7yoilsho	6127	23	CCK	CCK	NNP
cord-006229-7yoilsho	6127	24	)	)	-RRB-
cord-006229-7yoilsho	6127	25	analogue	analogue	JJ
cord-006229-7yoilsho	6127	26	cerulein	cerulein	NN
cord-006229-7yoilsho	6127	27	on	on	IN
cord-006229-7yoilsho	6127	28	the	the	DT
cord-006229-7yoilsho	6127	29	viability	viability	NN
cord-006229-7yoilsho	6127	30	and	and	CC
cord-006229-7yoilsho	6127	31	functional	functional	JJ
cord-006229-7yoilsho	6127	32	integrity	integrity	NN
cord-006229-7yoilsho	6127	33	of	of	IN
cord-006229-7yoilsho	6127	34	tissue	tissue	NN
cord-006229-7yoilsho	6127	35	slices	slice	NNS
cord-006229-7yoilsho	6127	36	were	be	VBD
cord-006229-7yoilsho	6127	37	compared	compare	VBN
cord-006229-7yoilsho	6127	38	to	to	IN
cord-006229-7yoilsho	6127	39	the	the	DT
cord-006229-7yoilsho	6127	40	respective	respective	JJ
cord-006229-7yoilsho	6127	41	responses	response	NNS
cord-006229-7yoilsho	6127	42	of	of	IN
cord-006229-7yoilsho	6127	43	the	the	DT
cord-006229-7yoilsho	6127	44	cell	cell	NN
cord-006229-7yoilsho	6127	45	lines	line	NNS
cord-006229-7yoilsho	6127	46	.	.	.
cord-006229-7yoilsho	6128	1	We	-PRON-	PRP
cord-006229-7yoilsho	6128	2	were	be	VBD
cord-006229-7yoilsho	6128	3	able	able	JJ
cord-006229-7yoilsho	6128	4	to	to	TO
cord-006229-7yoilsho	6128	5	establish	establish	VB
cord-006229-7yoilsho	6128	6	an	an	DT
cord-006229-7yoilsho	6128	7	optimized	optimize	VBN
cord-006229-7yoilsho	6128	8	isolation	isolation	NN
cord-006229-7yoilsho	6128	9	and	and	CC
cord-006229-7yoilsho	6128	10	cultivation	cultivation	NN
cord-006229-7yoilsho	6128	11	procedure	procedure	NN
cord-006229-7yoilsho	6128	12	for	for	IN
cord-006229-7yoilsho	6128	13	rat	rat	NN
cord-006229-7yoilsho	6128	14	pancreas	pancreas	NN
cord-006229-7yoilsho	6128	15	tissue	tissue	NN
cord-006229-7yoilsho	6128	16	slices	slice	NNS
cord-006229-7yoilsho	6128	17	applying	apply	VBG
cord-006229-7yoilsho	6128	18	minor	minor	JJ
cord-006229-7yoilsho	6128	19	modifications	modification	NNS
cord-006229-7yoilsho	6128	20	to	to	IN
cord-006229-7yoilsho	6128	21	the	the	DT
cord-006229-7yoilsho	6128	22	original	original	JJ
cord-006229-7yoilsho	6128	23	protocol	protocol	NN
cord-006229-7yoilsho	6128	24	.	.	.
cord-006229-7yoilsho	6129	1	Cell	cell	NN
cord-006229-7yoilsho	6129	2	viability	viability	NN
cord-006229-7yoilsho	6129	3	declined	decline	VBD
cord-006229-7yoilsho	6129	4	over	over	IN
cord-006229-7yoilsho	6129	5	the	the	DT
cord-006229-7yoilsho	6129	6	cultivation	cultivation	NN
cord-006229-7yoilsho	6129	7	period	period	NN
cord-006229-7yoilsho	6129	8	.	.	.
cord-006229-7yoilsho	6130	1	Stimulation	stimulation	NN
cord-006229-7yoilsho	6130	2	of	of	IN
cord-006229-7yoilsho	6130	3	the	the	DT
cord-006229-7yoilsho	6130	4	cell	cell	NN
cord-006229-7yoilsho	6130	5	lines	line	NNS
cord-006229-7yoilsho	6130	6	with	with	IN
cord-006229-7yoilsho	6130	7	glucose	glucose	NN
cord-006229-7yoilsho	6130	8	or	or	CC
cord-006229-7yoilsho	6130	9	cerulein	cerulein	NN
cord-006229-7yoilsho	6130	10	increased	increase	VBD
cord-006229-7yoilsho	6130	11	secretion	secretion	NN
cord-006229-7yoilsho	6130	12	of	of	IN
cord-006229-7yoilsho	6130	13	insulin	insulin	NN
cord-006229-7yoilsho	6130	14	(	(	-LRB-
cord-006229-7yoilsho	6130	15	INS-1E	INS-1E	NNP
cord-006229-7yoilsho	6130	16	cells	cell	NNS
cord-006229-7yoilsho	6130	17	)	)	-RRB-
cord-006229-7yoilsho	6130	18	or	or	CC
cord-006229-7yoilsho	6130	19	amylase	amylase	NN
cord-006229-7yoilsho	6130	20	/	/	SYM
cord-006229-7yoilsho	6130	21	lipase	lipase	NN
cord-006229-7yoilsho	6130	22	(	(	-LRB-
cord-006229-7yoilsho	6130	23	AR42J	AR42J	NNP
cord-006229-7yoilsho	6130	24	cells	cell	NNS
cord-006229-7yoilsho	6130	25	)	)	-RRB-
cord-006229-7yoilsho	6130	26	,	,	,
cord-006229-7yoilsho	6130	27	respectively	respectively	RB
cord-006229-7yoilsho	6130	28	.	.	.
cord-006229-7yoilsho	6131	1	The	the	DT
cord-006229-7yoilsho	6131	2	pancreas	pancreas	NN
cord-006229-7yoilsho	6131	3	slices	slice	NNS
cord-006229-7yoilsho	6131	4	responded	respond	VBD
cord-006229-7yoilsho	6131	5	to	to	IN
cord-006229-7yoilsho	6131	6	both	both	DT
cord-006229-7yoilsho	6131	7	stimuli	stimulus	NNS
cord-006229-7yoilsho	6131	8	,	,	,
cord-006229-7yoilsho	6131	9	demonstrating	demonstrate	VBG
cord-006229-7yoilsho	6131	10	functional	functional	JJ
cord-006229-7yoilsho	6131	11	integrity	integrity	NN
cord-006229-7yoilsho	6131	12	of	of	IN
cord-006229-7yoilsho	6131	13	endocrine	endocrine	JJ
cord-006229-7yoilsho	6131	14	and	and	CC
cord-006229-7yoilsho	6131	15	exocrine	exocrine	JJ
cord-006229-7yoilsho	6131	16	cells	cell	NNS
cord-006229-7yoilsho	6131	17	.	.	.
cord-006229-7yoilsho	6132	1	Treatment	treatment	NN
cord-006229-7yoilsho	6132	2	of	of	IN
cord-006229-7yoilsho	6132	3	INS-1E	INS-1E	NNP
cord-006229-7yoilsho	6132	4	islet	islet	NN
cord-006229-7yoilsho	6132	5	cells	cell	NNS
cord-006229-7yoilsho	6132	6	with	with	IN
cord-006229-7yoilsho	6132	7	the	the	DT
cord-006229-7yoilsho	6132	8	betacell	betacell	NN
cord-006229-7yoilsho	6132	9	toxicants	toxicant	NNS
cord-006229-7yoilsho	6132	10	ALL	all	DT
cord-006229-7yoilsho	6132	11	or	or	CC
cord-006229-7yoilsho	6132	12	STZ	STZ	NNP
cord-006229-7yoilsho	6133	1	only	only	RB
cord-006229-7yoilsho	6133	2	slightly	slightly	RB
cord-006229-7yoilsho	6133	3	affected	affect	VBN
cord-006229-7yoilsho	6133	4	islet	islet	NN
cord-006229-7yoilsho	6133	5	cell	cell	NN
cord-006229-7yoilsho	6133	6	viability	viability	NN
cord-006229-7yoilsho	6133	7	,	,	,
cord-006229-7yoilsho	6133	8	whereas	whereas	IN
cord-006229-7yoilsho	6133	9	treatment	treatment	NN
cord-006229-7yoilsho	6133	10	of	of	IN
cord-006229-7yoilsho	6133	11	AR42J	AR42J	NNP
cord-006229-7yoilsho	6133	12	acinar	acinar	NNP
cord-006229-7yoilsho	6133	13	cells	cell	NNS
cord-006229-7yoilsho	6133	14	with	with	IN
cord-006229-7yoilsho	6133	15	cerulein	cerulein	NNP
cord-006229-7yoilsho	6133	16	at	at	IN
cord-006229-7yoilsho	6133	17	supraphysiological	supraphysiological	JJ
cord-006229-7yoilsho	6133	18	concentrations	concentration	NNS
cord-006229-7yoilsho	6133	19	had	have	VBD
cord-006229-7yoilsho	6133	20	no	no	DT
cord-006229-7yoilsho	6133	21	effect	effect	NN
cord-006229-7yoilsho	6133	22	.	.	.
cord-006229-7yoilsho	6134	1	This	this	DT
cord-006229-7yoilsho	6134	2	set	set	NN
cord-006229-7yoilsho	6134	3	of	of	IN
cord-006229-7yoilsho	6134	4	experiments	experiment	NNS
cord-006229-7yoilsho	6134	5	is	be	VBZ
cord-006229-7yoilsho	6134	6	currently	currently	RB
cord-006229-7yoilsho	6134	7	completed	complete	VBN
cord-006229-7yoilsho	6134	8	by	by	IN
cord-006229-7yoilsho	6134	9	investigating	investigate	VBG
cord-006229-7yoilsho	6134	10	the	the	DT
cord-006229-7yoilsho	6134	11	effects	effect	NNS
cord-006229-7yoilsho	6134	12	of	of	IN
cord-006229-7yoilsho	6134	13	ALL	all	DT
cord-006229-7yoilsho	6134	14	,	,	,
cord-006229-7yoilsho	6134	15	STZ	STZ	NNP
cord-006229-7yoilsho	6134	16	and	and	CC
cord-006229-7yoilsho	6134	17	cerulein	cerulein	NN
cord-006229-7yoilsho	6134	18	on	on	IN
cord-006229-7yoilsho	6134	19	the	the	DT
cord-006229-7yoilsho	6134	20	viability	viability	NN
cord-006229-7yoilsho	6134	21	of	of	IN
cord-006229-7yoilsho	6134	22	acinar	acinar	JJ
cord-006229-7yoilsho	6134	23	and	and	CC
cord-006229-7yoilsho	6134	24	islet	islet	NN
cord-006229-7yoilsho	6134	25	cells	cell	NNS
cord-006229-7yoilsho	6134	26	in	in	IN
cord-006229-7yoilsho	6134	27	pancreas	pancreas	NN
cord-006229-7yoilsho	6134	28	slices	slice	NNS
cord-006229-7yoilsho	6134	29	.	.	.
cord-006229-7yoilsho	6135	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	6135	2	preliminary	preliminary	JJ
cord-006229-7yoilsho	6135	3	data	datum	NNS
cord-006229-7yoilsho	6135	4	demonstrate	demonstrate	VBP
cord-006229-7yoilsho	6135	5	feasibility	feasibility	NN
cord-006229-7yoilsho	6135	6	to	to	TO
cord-006229-7yoilsho	6135	7	prepare	prepare	VB
cord-006229-7yoilsho	6135	8	and	and	CC
cord-006229-7yoilsho	6135	9	cultivate	cultivate	VB
cord-006229-7yoilsho	6135	10	rat	rat	NN
cord-006229-7yoilsho	6135	11	pancreas	pancreas	NN
cord-006229-7yoilsho	6135	12	tissue	tissue	NN
cord-006229-7yoilsho	6135	13	slices	slice	NNS
cord-006229-7yoilsho	6135	14	over	over	IN
cord-006229-7yoilsho	6135	15	a	a	DT
cord-006229-7yoilsho	6135	16	period	period	NN
cord-006229-7yoilsho	6135	17	of	of	IN
cord-006229-7yoilsho	6135	18	6	6	CD
cord-006229-7yoilsho	6135	19	days	day	NNS
cord-006229-7yoilsho	6135	20	thereby	thereby	RB
cord-006229-7yoilsho	6135	21	maintaining	maintain	VBG
cord-006229-7yoilsho	6135	22	functional	functional	JJ
cord-006229-7yoilsho	6135	23	integrity	integrity	NN
cord-006229-7yoilsho	6135	24	to	to	IN
cord-006229-7yoilsho	6135	25	some	some	DT
cord-006229-7yoilsho	6135	26	extent	extent	NN
cord-006229-7yoilsho	6135	27	.	.	.
cord-006229-7yoilsho	6136	1	Coculture	Coculture	NNP
cord-006229-7yoilsho	6136	2	of	of	IN
cord-006229-7yoilsho	6136	3	human	human	JJ
cord-006229-7yoilsho	6136	4	monocytes	monocyte	NNS
cord-006229-7yoilsho	6136	5	with	with	IN
cord-006229-7yoilsho	6136	6	the	the	DT
cord-006229-7yoilsho	6136	7	keratinocyte	keratinocyte	NNP
cord-006229-7yoilsho	6136	8	cell	cell	NN
cord-006229-7yoilsho	6136	9	line	line	NN
cord-006229-7yoilsho	6136	10	HaCaT	HaCaT	NNP
cord-006229-7yoilsho	6137	1	in	in	IN
cord-006229-7yoilsho	6137	2	serumcontaining	serumcontaine	VBG
cord-006229-7yoilsho	6137	3	medium	medium	NN
cord-006229-7yoilsho	6137	4	leads	lead	VBZ
cord-006229-7yoilsho	6137	5	to	to	IN
cord-006229-7yoilsho	6137	6	higher	high	JJR
cord-006229-7yoilsho	6137	7	sensitivity	sensitivity	NN
cord-006229-7yoilsho	6137	8	to	to	IN
cord-006229-7yoilsho	6137	9	weak	weak	JJ
cord-006229-7yoilsho	6137	10	contact	contact	NN
cord-006229-7yoilsho	6137	11	allergens	allergen	NNS
cord-006229-7yoilsho	6137	12	:	:	:
cord-006229-7yoilsho	6138	1	an	an	DT
cord-006229-7yoilsho	6138	2	improvement	improvement	NN
cord-006229-7yoilsho	6138	3	for	for	IN
cord-006229-7yoilsho	6138	4	the	the	DT
cord-006229-7yoilsho	6138	5	Loose	Loose	NNP
cord-006229-7yoilsho	6138	6	-	-	HYPH
cord-006229-7yoilsho	6138	7	fit	fit	JJ
cord-006229-7yoilsho	6138	8	Coculture	coculture	NN
cord-006229-7yoilsho	6138	9	-	-	HYPH
cord-006229-7yoilsho	6138	10	based	base	VBN
cord-006229-7yoilsho	6138	11	Sensitization	Sensitization	NNP
cord-006229-7yoilsho	6138	12	Assay	Assay	NNP
cord-006229-7yoilsho	6138	13	(	(	-LRB-
cord-006229-7yoilsho	6138	14	LCSA	LCSA	NNP
cord-006229-7yoilsho	6138	15	)	)	-RRB-
cord-006229-7yoilsho	6138	16	A.	a.	NN
cord-006229-7yoilsho	6138	17	Sonnenburg	Sonnenburg	NNP
cord-006229-7yoilsho	6138	18	1	1	CD
cord-006229-7yoilsho	6138	19	,	,	,
cord-006229-7yoilsho	6138	20	J.	J.	NNP
cord-006229-7yoilsho	6138	21	The	the	DT
cord-006229-7yoilsho	6138	22	Loose	Loose	NNP
cord-006229-7yoilsho	6138	23	-	-	HYPH
cord-006229-7yoilsho	6138	24	fit	fit	JJ
cord-006229-7yoilsho	6138	25	Coculture	coculture	NN
cord-006229-7yoilsho	6138	26	-	-	HYPH
cord-006229-7yoilsho	6138	27	based	base	VBN
cord-006229-7yoilsho	6138	28	Sensitization	Sensitization	NNP
cord-006229-7yoilsho	6138	29	Assay	Assay	NNP
cord-006229-7yoilsho	6138	30	(	(	-LRB-
cord-006229-7yoilsho	6138	31	LCSA	LCSA	NNP
cord-006229-7yoilsho	6138	32	)	)	-RRB-
cord-006229-7yoilsho	6138	33	has	have	VBZ
cord-006229-7yoilsho	6138	34	proved	prove	VBN
cord-006229-7yoilsho	6138	35	reliable	reliable	JJ
cord-006229-7yoilsho	6138	36	for	for	IN
cord-006229-7yoilsho	6138	37	the	the	DT
cord-006229-7yoilsho	6138	38	in	in	FW
cord-006229-7yoilsho	6138	39	vitro	vitro	FW
cord-006229-7yoilsho	6138	40	detection	detection	NN
cord-006229-7yoilsho	6138	41	of	of	IN
cord-006229-7yoilsho	6138	42	contact	contact	NN
cord-006229-7yoilsho	6138	43	sensitizers	sensitizer	NNS
cord-006229-7yoilsho	6138	44	in	in	IN
cord-006229-7yoilsho	6138	45	the	the	DT
cord-006229-7yoilsho	6138	46	past	past	NN
cord-006229-7yoilsho	6138	47	.	.	.
cord-006229-7yoilsho	6139	1	However	however	RB
cord-006229-7yoilsho	6139	2	,	,	,
cord-006229-7yoilsho	6139	3	the	the	DT
cord-006229-7yoilsho	6139	4	use	use	NN
cord-006229-7yoilsho	6139	5	of	of	IN
cord-006229-7yoilsho	6139	6	primary	primary	JJ
cord-006229-7yoilsho	6139	7	human	human	JJ
cord-006229-7yoilsho	6139	8	keratinocytes	keratinocyte	NNS
cord-006229-7yoilsho	6139	9	has	have	VBZ
cord-006229-7yoilsho	6139	10	some	some	DT
cord-006229-7yoilsho	6139	11	disadvantages	disadvantage	NNS
cord-006229-7yoilsho	6139	12	.	.	.
cord-006229-7yoilsho	6140	1	To	to	TO
cord-006229-7yoilsho	6140	2	facilitate	facilitate	VB
cord-006229-7yoilsho	6140	3	high	high	JJ
cord-006229-7yoilsho	6140	4	throughput	throughput	NN
cord-006229-7yoilsho	6140	5	screening	screening	NN
cord-006229-7yoilsho	6140	6	of	of	IN
cord-006229-7yoilsho	6140	7	chemicals	chemical	NNS
cord-006229-7yoilsho	6140	8	,	,	,
cord-006229-7yoilsho	6140	9	we	-PRON-	PRP
cord-006229-7yoilsho	6140	10	replaced	replace	VBD
cord-006229-7yoilsho	6140	11	primary	primary	JJ
cord-006229-7yoilsho	6140	12	keratinocytes	keratinocyte	NNS
cord-006229-7yoilsho	6140	13	from	from	IN
cord-006229-7yoilsho	6140	14	the	the	DT
cord-006229-7yoilsho	6140	15	original	original	JJ
cord-006229-7yoilsho	6140	16	assay	assay	NN
cord-006229-7yoilsho	6140	17	setup	setup	NN
cord-006229-7yoilsho	6140	18	(	(	-LRB-
cord-006229-7yoilsho	6140	19	setup	setup	VB
cord-006229-7yoilsho	6140	20	A	a	NN
cord-006229-7yoilsho	6140	21	)	)	-RRB-
cord-006229-7yoilsho	6140	22	by	by	IN
cord-006229-7yoilsho	6140	23	the	the	DT
cord-006229-7yoilsho	6140	24	human	human	JJ
cord-006229-7yoilsho	6140	25	keratinocyte	keratinocyte	NNP
cord-006229-7yoilsho	6140	26	cell	cell	NN
cord-006229-7yoilsho	6140	27	line	line	NN
cord-006229-7yoilsho	6140	28	HaCaT.	hacat.	JJ
cord-006229-7yoilsho	6141	1	These	these	DT
cord-006229-7yoilsho	6141	2	cells	cell	NNS
cord-006229-7yoilsho	6141	3	were	be	VBD
cord-006229-7yoilsho	6141	4	cocultured	coculture	VBN
cord-006229-7yoilsho	6141	5	with	with	IN
cord-006229-7yoilsho	6141	6	monocytederived	monocytederived	JJ
cord-006229-7yoilsho	6141	7	dendritic	dendritic	JJ
cord-006229-7yoilsho	6141	8	cells	cell	NNS
cord-006229-7yoilsho	6141	9	in	in	IN
cord-006229-7yoilsho	6141	10	serum	serum	NN
cord-006229-7yoilsho	6141	11	-	-	HYPH
cord-006229-7yoilsho	6141	12	free	free	JJ
cord-006229-7yoilsho	6141	13	medium	medium	NN
cord-006229-7yoilsho	6141	14	(	(	-LRB-
cord-006229-7yoilsho	6141	15	setup	setup	NN
cord-006229-7yoilsho	6141	16	B	b	NN
cord-006229-7yoilsho	6141	17	)	)	-RRB-
cord-006229-7yoilsho	6141	18	or	or	CC
cord-006229-7yoilsho	6141	19	fetal	fetal	JJ
cord-006229-7yoilsho	6141	20	calf	calf	NN
cord-006229-7yoilsho	6141	21	serum	serum	NN
cord-006229-7yoilsho	6141	22	(	(	-LRB-
cord-006229-7yoilsho	6141	23	FCS)containing	fcs)containe	VBG
cord-006229-7yoilsho	6141	24	medium	medium	NN
cord-006229-7yoilsho	6141	25	(	(	-LRB-
cord-006229-7yoilsho	6141	26	setup	setup	NN
cord-006229-7yoilsho	6141	27	C	C	NNP
cord-006229-7yoilsho	6141	28	)	)	-RRB-
cord-006229-7yoilsho	6141	29	.	.	.
cord-006229-7yoilsho	6142	1	Upregulation	Upregulation	NNP
cord-006229-7yoilsho	6142	2	of	of	IN
cord-006229-7yoilsho	6142	3	the	the	DT
cord-006229-7yoilsho	6142	4	dendritic	dendritic	JJ
cord-006229-7yoilsho	6142	5	cell	cell	NN
cord-006229-7yoilsho	6142	6	maturation	maturation	NN
cord-006229-7yoilsho	6142	7	marker	marker	NN
cord-006229-7yoilsho	6142	8	CD86	CD86	NNP
cord-006229-7yoilsho	6142	9	assessed	assess	VBN
cord-006229-7yoilsho	6142	10	by	by	IN
cord-006229-7yoilsho	6142	11	flow	flow	NN
cord-006229-7yoilsho	6142	12	cytometry	cytometry	NN
cord-006229-7yoilsho	6142	13	served	serve	VBD
cord-006229-7yoilsho	6142	14	as	as	IN
cord-006229-7yoilsho	6142	15	endpoint	endpoint	NN
cord-006229-7yoilsho	6142	16	.	.	.
cord-006229-7yoilsho	6143	1	We	-PRON-	PRP
cord-006229-7yoilsho	6143	2	have	have	VBP
cord-006229-7yoilsho	6143	3	tested	test	VBN
cord-006229-7yoilsho	6143	4	four	four	CD
cord-006229-7yoilsho	6143	5	substances	substance	NNS
cord-006229-7yoilsho	6143	6	known	know	VBN
cord-006229-7yoilsho	6143	7	as	as	IN
cord-006229-7yoilsho	6143	8	sensitizers	sensitizer	NNS
cord-006229-7yoilsho	6143	9	and	and	CC
cord-006229-7yoilsho	6143	10	four	four	CD
cord-006229-7yoilsho	6143	11	non	non	JJ
cord-006229-7yoilsho	6143	12	-	-	NNS
cord-006229-7yoilsho	6143	13	sensitizers	sensitizer	NNS
cord-006229-7yoilsho	6143	14	in	in	IN
cord-006229-7yoilsho	6143	15	both	both	DT
cord-006229-7yoilsho	6143	16	new	new	JJ
cord-006229-7yoilsho	6143	17	setups	setup	NNS
cord-006229-7yoilsho	6143	18	as	as	RB
cord-006229-7yoilsho	6143	19	well	well	RB
cord-006229-7yoilsho	6143	20	as	as	IN
cord-006229-7yoilsho	6143	21	in	in	IN
cord-006229-7yoilsho	6143	22	the	the	DT
cord-006229-7yoilsho	6143	23	original	original	JJ
cord-006229-7yoilsho	6143	24	setup	setup	NN
cord-006229-7yoilsho	6143	25	with	with	IN
cord-006229-7yoilsho	6143	26	primary	primary	JJ
cord-006229-7yoilsho	6143	27	cells	cell	NNS
cord-006229-7yoilsho	6143	28	.	.	.
cord-006229-7yoilsho	6144	1	Three	three	CD
cord-006229-7yoilsho	6144	2	out	out	IN
cord-006229-7yoilsho	6144	3	of	of	IN
cord-006229-7yoilsho	6144	4	four	four	CD
cord-006229-7yoilsho	6144	5	sensitizers	sensitizer	NNS
cord-006229-7yoilsho	6144	6	(	(	-LRB-
cord-006229-7yoilsho	6144	7	2,4-dinitrochlorobenzene	2,4-dinitrochlorobenzene	CD
cord-006229-7yoilsho	6144	8	,	,	,
cord-006229-7yoilsho	6144	9	2-mercaptobenzothiazole	2-mercaptobenzothiazole	CD
cord-006229-7yoilsho	6144	10	,	,	,
cord-006229-7yoilsho	6144	11	and	and	CC
cord-006229-7yoilsho	6144	12	coumarin	coumarin	NN
cord-006229-7yoilsho	6144	13	)	)	-RRB-
cord-006229-7yoilsho	6144	14	,	,	,
cord-006229-7yoilsho	6144	15	and	and	CC
cord-006229-7yoilsho	6144	16	three	three	CD
cord-006229-7yoilsho	6144	17	out	out	IN
cord-006229-7yoilsho	6144	18	of	of	IN
cord-006229-7yoilsho	6144	19	four	four	CD
cord-006229-7yoilsho	6144	20	non	non	JJ
cord-006229-7yoilsho	6144	21	-	-	NNS
cord-006229-7yoilsho	6144	22	sensitizers	sensitizer	NNS
cord-006229-7yoilsho	6144	23	(	(	-LRB-
cord-006229-7yoilsho	6144	24	glycerol	glycerol	NN
cord-006229-7yoilsho	6144	25	,	,	,
cord-006229-7yoilsho	6144	26	monochlorobenzene	monochlorobenzene	NN
cord-006229-7yoilsho	6144	27	,	,	,
cord-006229-7yoilsho	6144	28	and	and	CC
cord-006229-7yoilsho	6144	29	salicylic	salicylic	JJ
cord-006229-7yoilsho	6144	30	acid	acid	NN
cord-006229-7yoilsho	6144	31	)	)	-RRB-
cord-006229-7yoilsho	6144	32	were	be	VBD
cord-006229-7yoilsho	6144	33	correctly	correctly	RB
cord-006229-7yoilsho	6144	34	assessed	assess	VBN
cord-006229-7yoilsho	6144	35	under	under	IN
cord-006229-7yoilsho	6144	36	all	all	DT
cord-006229-7yoilsho	6144	37	culture	culture	NN
cord-006229-7yoilsho	6144	38	conditions	condition	NNS
cord-006229-7yoilsho	6144	39	.	.	.
cord-006229-7yoilsho	6145	1	The	the	DT
cord-006229-7yoilsho	6145	2	weak	weak	JJ
cord-006229-7yoilsho	6145	3	sensitizing	sensitize	VBG
cord-006229-7yoilsho	6145	4	potency	potency	NN
cord-006229-7yoilsho	6145	5	of	of	IN
cord-006229-7yoilsho	6145	6	resorcinol	resorcinol	NNP
cord-006229-7yoilsho	6145	7	was	be	VBD
cord-006229-7yoilsho	6145	8	only	only	RB
cord-006229-7yoilsho	6145	9	detected	detect	VBN
cord-006229-7yoilsho	6145	10	by	by	IN
cord-006229-7yoilsho	6145	11	setup	setup	NN
cord-006229-7yoilsho	6145	12	B	b	NN
cord-006229-7yoilsho	6145	13	with	with	IN
cord-006229-7yoilsho	6145	14	FCS	FCS	NNP
cord-006229-7yoilsho	6145	15	supplemented	supplement	VBD
cord-006229-7yoilsho	6145	16	medium	medium	NN
cord-006229-7yoilsho	6145	17	.	.	.
cord-006229-7yoilsho	6146	1	A	a	DT
cord-006229-7yoilsho	6146	2	false	false	JJ
cord-006229-7yoilsho	6146	3	positive	positive	JJ
cord-006229-7yoilsho	6146	4	reaction	reaction	NN
cord-006229-7yoilsho	6146	5	to	to	IN
cord-006229-7yoilsho	6146	6	caprylic	caprylic	NNP
cord-006229-7yoilsho	6146	7	(	(	-LRB-
cord-006229-7yoilsho	6146	8	octanoic	octanoic	NNP
cord-006229-7yoilsho	6146	9	)	)	-RRB-
cord-006229-7yoilsho	6146	10	acid	acid	NN
cord-006229-7yoilsho	6146	11	in	in	IN
cord-006229-7yoilsho	6146	12	all	all	DT
cord-006229-7yoilsho	6146	13	three	three	CD
cord-006229-7yoilsho	6146	14	setups	setup	NNS
cord-006229-7yoilsho	6146	15	confirms	confirm	VBZ
cord-006229-7yoilsho	6146	16	earlier	early	JJR
cord-006229-7yoilsho	6146	17	results	result	NNS
cord-006229-7yoilsho	6146	18	from	from	IN
cord-006229-7yoilsho	6146	19	our	-PRON-	PRP$
cord-006229-7yoilsho	6146	20	laboratory	laboratory	NN
cord-006229-7yoilsho	6146	21	that	that	IN
cord-006229-7yoilsho	6146	22	some	some	DT
cord-006229-7yoilsho	6146	23	fatty	fatty	JJ
cord-006229-7yoilsho	6146	24	acids	acid	NNS
cord-006229-7yoilsho	6146	25	are	be	VBP
cord-006229-7yoilsho	6146	26	able	able	JJ
cord-006229-7yoilsho	6146	27	to	to	TO
cord-006229-7yoilsho	6146	28	induce	induce	VB
cord-006229-7yoilsho	6146	29	CD86	CD86	NNP
cord-006229-7yoilsho	6146	30	on	on	IN
cord-006229-7yoilsho	6146	31	dendritic	dendritic	JJ
cord-006229-7yoilsho	6146	32	cells	cell	NNS
cord-006229-7yoilsho	6146	33	in	in	IN
cord-006229-7yoilsho	6146	34	vitro	vitro	FW
cord-006229-7yoilsho	6146	35	.	.	.
cord-006229-7yoilsho	6147	1	Culture	culture	NN
cord-006229-7yoilsho	6147	2	in	in	IN
cord-006229-7yoilsho	6147	3	FCS	FCS	NNP
cord-006229-7yoilsho	6147	4	supplemented	supplement	VBD
cord-006229-7yoilsho	6147	5	medium	medium	NN
cord-006229-7yoilsho	6147	6	led	lead	VBD
cord-006229-7yoilsho	6147	7	to	to	IN
cord-006229-7yoilsho	6147	8	generation	generation	NN
cord-006229-7yoilsho	6147	9	of	of	IN
cord-006229-7yoilsho	6147	10	dendritic	dendritic	JJ
cord-006229-7yoilsho	6147	11	cells	cell	NNS
cord-006229-7yoilsho	6147	12	showing	show	VBG
cord-006229-7yoilsho	6147	13	a	a	DT
cord-006229-7yoilsho	6147	14	more	more	RBR
cord-006229-7yoilsho	6147	15	pronounced	pronounce	VBN
cord-006229-7yoilsho	6147	16	upregulation	upregulation	NN
cord-006229-7yoilsho	6147	17	of	of	IN
cord-006229-7yoilsho	6147	18	CD86	CD86	NNP
cord-006229-7yoilsho	6147	19	after	after	IN
cord-006229-7yoilsho	6147	20	application	application	NN
cord-006229-7yoilsho	6147	21	of	of	IN
cord-006229-7yoilsho	6147	22	substances	substance	NNS
cord-006229-7yoilsho	6147	23	with	with	IN
cord-006229-7yoilsho	6147	24	rather	rather	RB
cord-006229-7yoilsho	6147	25	high	high	JJ
cord-006229-7yoilsho	6147	26	sensitization	sensitization	NN
cord-006229-7yoilsho	6147	27	potency	potency	NN
cord-006229-7yoilsho	6147	28	compared	compare	VBN
cord-006229-7yoilsho	6147	29	to	to	IN
cord-006229-7yoilsho	6147	30	dendritic	dendritic	JJ
cord-006229-7yoilsho	6147	31	cells	cell	NNS
cord-006229-7yoilsho	6147	32	which	which	WDT
cord-006229-7yoilsho	6147	33	are	be	VBP
cord-006229-7yoilsho	6147	34	formed	form	VBN
cord-006229-7yoilsho	6147	35	under	under	IN
cord-006229-7yoilsho	6147	36	serum	serum	NN
cord-006229-7yoilsho	6147	37	-	-	HYPH
cord-006229-7yoilsho	6147	38	free	free	JJ
cord-006229-7yoilsho	6147	39	conditions	condition	NNS
cord-006229-7yoilsho	6147	40	.	.	.
cord-006229-7yoilsho	6148	1	Therefore	therefore	RB
cord-006229-7yoilsho	6148	2	,	,	,
cord-006229-7yoilsho	6148	3	we	-PRON-	PRP
cord-006229-7yoilsho	6148	4	characterized	characterize	VBD
cord-006229-7yoilsho	6148	5	dendritic	dendritic	JJ
cord-006229-7yoilsho	6148	6	cells	cell	NNS
cord-006229-7yoilsho	6148	7	from	from	IN
cord-006229-7yoilsho	6148	8	setups	setup	NNS
cord-006229-7yoilsho	6148	9	B	b	NN
cord-006229-7yoilsho	6148	10	and	and	CC
cord-006229-7yoilsho	6148	11	C	c	NN
cord-006229-7yoilsho	6148	12	by	by	IN
cord-006229-7yoilsho	6148	13	flow	flow	NN
cord-006229-7yoilsho	6148	14	cytometric	cytometric	NN
cord-006229-7yoilsho	6148	15	measurement	measurement	NN
cord-006229-7yoilsho	6148	16	of	of	IN
cord-006229-7yoilsho	6148	17	additional	additional	JJ
cord-006229-7yoilsho	6148	18	dendritic	dendritic	JJ
cord-006229-7yoilsho	6148	19	cell	cell	NN
cord-006229-7yoilsho	6148	20	surface	surface	NN
cord-006229-7yoilsho	6148	21	markers	marker	NNS
cord-006229-7yoilsho	6148	22	.	.	.
cord-006229-7yoilsho	6149	1	Dendritic	dendritic	JJ
cord-006229-7yoilsho	6149	2	cells	cell	NNS
cord-006229-7yoilsho	6149	3	from	from	IN
cord-006229-7yoilsho	6149	4	the	the	DT
cord-006229-7yoilsho	6149	5	original	original	JJ
cord-006229-7yoilsho	6149	6	setup	setup	NN
cord-006229-7yoilsho	6150	1	A	a	DT
cord-006229-7yoilsho	6150	2	had	have	VBD
cord-006229-7yoilsho	6150	3	been	be	VBN
cord-006229-7yoilsho	6150	4	characterized	characterize	VBN
cord-006229-7yoilsho	6150	5	extensively	extensively	RB
cord-006229-7yoilsho	6150	6	before	before	RB
cord-006229-7yoilsho	6150	7	(	(	-LRB-
cord-006229-7yoilsho	6150	8	Schreiner	Schreiner	NNP
cord-006229-7yoilsho	6150	9	et	et	NNP
cord-006229-7yoilsho	6150	10	al	al	NNP
cord-006229-7yoilsho	6150	11	.	.	NNP
cord-006229-7yoilsho	6150	12	,	,	,
cord-006229-7yoilsho	6150	13	Toxicology	Toxicology	NNP
cord-006229-7yoilsho	6150	14	2008	2008	CD
cord-006229-7yoilsho	6150	15	;	;	:
cord-006229-7yoilsho	6150	16	249:146	249:146	CD
cord-006229-7yoilsho	6150	17	-	-	HYPH
cord-006229-7yoilsho	6150	18	1529	1529	CD
cord-006229-7yoilsho	6150	19	)	)	-RRB-
cord-006229-7yoilsho	6150	20	.	.	.
cord-006229-7yoilsho	6151	1	Dendritic	dendritic	JJ
cord-006229-7yoilsho	6151	2	cells	cell	NNS
cord-006229-7yoilsho	6151	3	generated	generate	VBN
cord-006229-7yoilsho	6151	4	in	in	IN
cord-006229-7yoilsho	6151	5	FCS	FCS	NNP
cord-006229-7yoilsho	6151	6	supplemented	supplement	VBN
cord-006229-7yoilsho	6151	7	medium	medium	NN
cord-006229-7yoilsho	6151	8	were	be	VBD
cord-006229-7yoilsho	6151	9	CD1a+/CD1c+	CD1a+/CD1c+	NNS
cord-006229-7yoilsho	6151	10	,	,	,
cord-006229-7yoilsho	6151	11	whereas	whereas	IN
cord-006229-7yoilsho	6151	12	dendritic	dendritic	JJ
cord-006229-7yoilsho	6151	13	cells	cell	NNS
cord-006229-7yoilsho	6151	14	from	from	IN
cord-006229-7yoilsho	6151	15	serum	serum	NN
cord-006229-7yoilsho	6151	16	free	free	JJ
cord-006229-7yoilsho	6151	17	culture	culture	NN
cord-006229-7yoilsho	6151	18	conditions	condition	NNS
cord-006229-7yoilsho	6151	19	were	be	VBD
cord-006229-7yoilsho	6151	20	CD1a−/CD1c−	CD1a−/CD1c−	VBG
cord-006229-7yoilsho	6151	21	regardless	regardless	RB
cord-006229-7yoilsho	6151	22	whether	whether	IN
cord-006229-7yoilsho	6151	23	cocultured	coculture	VBN
cord-006229-7yoilsho	6151	24	with	with	IN
cord-006229-7yoilsho	6151	25	primary	primary	JJ
cord-006229-7yoilsho	6151	26	human	human	JJ
cord-006229-7yoilsho	6151	27	keratinocytes	keratinocyte	NNS
cord-006229-7yoilsho	6151	28	or	or	CC
cord-006229-7yoilsho	6151	29	HaCaT.	HaCaT.	NNP
cord-006229-7yoilsho	6151	30	Populations	Populations	NNPS
cord-006229-7yoilsho	6151	31	with	with	IN
cord-006229-7yoilsho	6151	32	CD1a+/CD1c+	CD1a+/CD1c+	HYPH
cord-006229-7yoilsho	6151	33	dendritic	dendritic	JJ
cord-006229-7yoilsho	6151	34	cells	cell	NNS
cord-006229-7yoilsho	6151	35	in	in	IN
cord-006229-7yoilsho	6151	36	coculture	coculture	NN
cord-006229-7yoilsho	6151	37	seem	seem	VBP
cord-006229-7yoilsho	6151	38	to	to	TO
cord-006229-7yoilsho	6151	39	show	show	VB
cord-006229-7yoilsho	6151	40	a	a	DT
cord-006229-7yoilsho	6151	41	higher	high	JJR
cord-006229-7yoilsho	6151	42	sensitivity	sensitivity	NN
cord-006229-7yoilsho	6151	43	to	to	IN
cord-006229-7yoilsho	6151	44	weak	weak	JJ
cord-006229-7yoilsho	6151	45	sensitizers	sensitizer	NNS
cord-006229-7yoilsho	6151	46	,	,	,
cord-006229-7yoilsho	6151	47	which	which	WDT
cord-006229-7yoilsho	6151	48	proved	prove	VBD
cord-006229-7yoilsho	6151	49	beneficial	beneficial	JJ
cord-006229-7yoilsho	6151	50	for	for	IN
cord-006229-7yoilsho	6151	51	the	the	DT
cord-006229-7yoilsho	6151	52	identification	identification	NN
cord-006229-7yoilsho	6151	53	of	of	IN
cord-006229-7yoilsho	6151	54	resorcinol	resorcinol	NNP
cord-006229-7yoilsho	6151	55	.	.	.
cord-006229-7yoilsho	6152	1	In	in	IN
cord-006229-7yoilsho	6152	2	conclusion	conclusion	NN
cord-006229-7yoilsho	6152	3	,	,	,
cord-006229-7yoilsho	6152	4	modification	modification	NN
cord-006229-7yoilsho	6152	5	of	of	IN
cord-006229-7yoilsho	6152	6	the	the	DT
cord-006229-7yoilsho	6152	7	LCSA	LCSA	NNP
cord-006229-7yoilsho	6152	8	protocol	protocol	NN
cord-006229-7yoilsho	6152	9	led	lead	VBD
cord-006229-7yoilsho	6152	10	to	to	IN
cord-006229-7yoilsho	6152	11	an	an	DT
cord-006229-7yoilsho	6152	12	increased	increase	VBN
cord-006229-7yoilsho	6152	13	sensitivity	sensitivity	NN
cord-006229-7yoilsho	6152	14	of	of	IN
cord-006229-7yoilsho	6152	15	the	the	DT
cord-006229-7yoilsho	6152	16	assay	assay	NN
cord-006229-7yoilsho	6152	17	.	.	.
cord-006229-7yoilsho	6153	1	Due	due	IN
cord-006229-7yoilsho	6153	2	to	to	IN
cord-006229-7yoilsho	6153	3	ethical	ethical	JJ
cord-006229-7yoilsho	6153	4	and	and	CC
cord-006229-7yoilsho	6153	5	social	social	JJ
cord-006229-7yoilsho	6153	6	reasons	reason	NNS
cord-006229-7yoilsho	6153	7	,	,	,
cord-006229-7yoilsho	6153	8	in	in	IN
cord-006229-7yoilsho	6153	9	vitro	vitro	FW
cord-006229-7yoilsho	6153	10	assays	assay	NNS
cord-006229-7yoilsho	6153	11	are	be	VBP
cord-006229-7yoilsho	6153	12	being	be	VBG
cord-006229-7yoilsho	6153	13	developed	develop	VBN
cord-006229-7yoilsho	6153	14	to	to	TO
cord-006229-7yoilsho	6153	15	replace	replace	VB
cord-006229-7yoilsho	6153	16	animal	animal	NN
cord-006229-7yoilsho	6153	17	tests	test	NNS
cord-006229-7yoilsho	6153	18	for	for	IN
cord-006229-7yoilsho	6153	19	addressing	address	VBG
cord-006229-7yoilsho	6153	20	e.g.	e.g.	RB
cord-006229-7yoilsho	6153	21	toxicological	toxicological	JJ
cord-006229-7yoilsho	6153	22	questions	question	NNS
cord-006229-7yoilsho	6153	23	.	.	.
cord-006229-7yoilsho	6154	1	For	for	IN
cord-006229-7yoilsho	6154	2	the	the	DT
cord-006229-7yoilsho	6154	3	induction	induction	NN
cord-006229-7yoilsho	6154	4	of	of	IN
cord-006229-7yoilsho	6154	5	skin	skin	NN
cord-006229-7yoilsho	6154	6	sensitization	sensitization	NN
cord-006229-7yoilsho	6154	7	by	by	IN
cord-006229-7yoilsho	6154	8	chemicals	chemical	NNS
cord-006229-7yoilsho	6154	9	,	,	,
cord-006229-7yoilsho	6154	10	resulting	result	VBG
cord-006229-7yoilsho	6154	11	in	in	IN
cord-006229-7yoilsho	6154	12	tolerance	tolerance	NN
cord-006229-7yoilsho	6154	13	or	or	CC
cord-006229-7yoilsho	6154	14	allergic	allergic	JJ
cord-006229-7yoilsho	6154	15	contact	contact	NN
cord-006229-7yoilsho	6154	16	dermatitis	dermatitis	NN
cord-006229-7yoilsho	6154	17	after	after	IN
cord-006229-7yoilsho	6154	18	repeated	repeat	VBN
cord-006229-7yoilsho	6154	19	exposure	exposure	NN
cord-006229-7yoilsho	6154	20	,	,	,
cord-006229-7yoilsho	6154	21	prerequisites	prerequisite	NNS
cord-006229-7yoilsho	6154	22	are	be	VBP
cord-006229-7yoilsho	6154	23	the	the	DT
cord-006229-7yoilsho	6154	24	induction	induction	NN
cord-006229-7yoilsho	6154	25	of	of	IN
cord-006229-7yoilsho	6154	26	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	6154	27	responses	response	NNS
cord-006229-7yoilsho	6154	28	in	in	IN
cord-006229-7yoilsho	6154	29	keratinocytes	keratinocyte	NNS
cord-006229-7yoilsho	6154	30	supporting	support	VBG
cord-006229-7yoilsho	6154	31	maturation	maturation	NN
cord-006229-7yoilsho	6154	32	of	of	IN
cord-006229-7yoilsho	6154	33	dendritic	dendritic	JJ
cord-006229-7yoilsho	6154	34	cells	cell	NNS
cord-006229-7yoilsho	6154	35	(	(	-LRB-
cord-006229-7yoilsho	6154	36	DC	DC	NNP
cord-006229-7yoilsho	6154	37	)	)	-RRB-
cord-006229-7yoilsho	6154	38	,	,	,
cord-006229-7yoilsho	6154	39	which	which	WDT
cord-006229-7yoilsho	6154	40	is	be	VBZ
cord-006229-7yoilsho	6154	41	needed	need	VBN
cord-006229-7yoilsho	6154	42	for	for	IN
cord-006229-7yoilsho	6154	43	the	the	DT
cord-006229-7yoilsho	6154	44	T	T	NNP
cord-006229-7yoilsho	6154	45	cell	cell	NN
cord-006229-7yoilsho	6154	46	response	response	NN
cord-006229-7yoilsho	6154	47	.	.	.
cord-006229-7yoilsho	6155	1	Although	although	IN
cord-006229-7yoilsho	6155	2	related	relate	VBN
cord-006229-7yoilsho	6155	3	in	in	IN
cord-006229-7yoilsho	6155	4	vitro	vitro	FW
cord-006229-7yoilsho	6155	5	assays	assay	NNS
cord-006229-7yoilsho	6155	6	consisting	consist	VBG
cord-006229-7yoilsho	6155	7	of	of	IN
cord-006229-7yoilsho	6155	8	one	one	CD
cord-006229-7yoilsho	6155	9	single	single	JJ
cord-006229-7yoilsho	6155	10	cell	cell	NN
cord-006229-7yoilsho	6155	11	type	type	NN
cord-006229-7yoilsho	6155	12	have	have	VBP
cord-006229-7yoilsho	6155	13	good	good	JJ
cord-006229-7yoilsho	6155	14	hazard	hazard	NN
cord-006229-7yoilsho	6155	15	prediction	prediction	NN
cord-006229-7yoilsho	6155	16	capacities	capacity	NNS
cord-006229-7yoilsho	6155	17	,	,	,
cord-006229-7yoilsho	6155	18	they	-PRON-	PRP
cord-006229-7yoilsho	6155	19	have	have	VBP
cord-006229-7yoilsho	6155	20	limitations	limitation	NNS
cord-006229-7yoilsho	6155	21	in	in	IN
cord-006229-7yoilsho	6155	22	predicting	predict	VBG
cord-006229-7yoilsho	6155	23	sensitization	sensitization	NN
cord-006229-7yoilsho	6155	24	potency	potency	NN
cord-006229-7yoilsho	6155	25	.	.	.
cord-006229-7yoilsho	6156	1	One	one	CD
cord-006229-7yoilsho	6156	2	drawback	drawback	NN
cord-006229-7yoilsho	6156	3	could	could	MD
cord-006229-7yoilsho	6156	4	be	be	VB
cord-006229-7yoilsho	6156	5	the	the	DT
cord-006229-7yoilsho	6156	6	lack	lack	NN
cord-006229-7yoilsho	6156	7	of	of	IN
cord-006229-7yoilsho	6156	8	communication	communication	NN
cord-006229-7yoilsho	6156	9	between	between	IN
cord-006229-7yoilsho	6156	10	keratinocytes	keratinocyte	NNS
cord-006229-7yoilsho	6156	11	and	and	CC
cord-006229-7yoilsho	6156	12	DC	DC	NNP
cord-006229-7yoilsho	6156	13	.	.	.
cord-006229-7yoilsho	6157	1	With	with	IN
cord-006229-7yoilsho	6157	2	respect	respect	NN
cord-006229-7yoilsho	6157	3	to	to	IN
cord-006229-7yoilsho	6157	4	the	the	DT
cord-006229-7yoilsho	6157	5	activation	activation	NN
cord-006229-7yoilsho	6157	6	of	of	IN
cord-006229-7yoilsho	6157	7	keratinocytes	keratinocyte	NNS
cord-006229-7yoilsho	6157	8	and	and	CC
cord-006229-7yoilsho	6157	9	maturation	maturation	NN
cord-006229-7yoilsho	6157	10	of	of	IN
cord-006229-7yoilsho	6157	11	DC	DC	NNP
cord-006229-7yoilsho	6157	12	,	,	,
cord-006229-7yoilsho	6157	13	intercellular	intercellular	JJ
cord-006229-7yoilsho	6157	14	communication	communication	NN
cord-006229-7yoilsho	6157	15	between	between	IN
cord-006229-7yoilsho	6157	16	these	these	DT
cord-006229-7yoilsho	6157	17	two	two	CD
cord-006229-7yoilsho	6157	18	cells	cell	NNS
cord-006229-7yoilsho	6157	19	may	may	MD
cord-006229-7yoilsho	6157	20	include	include	VB
cord-006229-7yoilsho	6157	21	the	the	DT
cord-006229-7yoilsho	6157	22	release	release	NN
cord-006229-7yoilsho	6157	23	of	of	IN
cord-006229-7yoilsho	6157	24	danger	danger	NN
cord-006229-7yoilsho	6157	25	molecules	molecule	NNS
cord-006229-7yoilsho	6157	26	such	such	JJ
cord-006229-7yoilsho	6157	27	as	as	IN
cord-006229-7yoilsho	6157	28	cytokines	cytokine	NNS
cord-006229-7yoilsho	6157	29	,	,	,
cord-006229-7yoilsho	6157	30	damage	damage	NN
cord-006229-7yoilsho	6157	31	-	-	HYPH
cord-006229-7yoilsho	6157	32	associated	associate	VBN
cord-006229-7yoilsho	6157	33	molecules	molecule	NNS
cord-006229-7yoilsho	6157	34	such	such	JJ
cord-006229-7yoilsho	6157	35	as	as	IN
cord-006229-7yoilsho	6157	36	ATP	ATP	NNP
cord-006229-7yoilsho	6157	37	,	,	,
cord-006229-7yoilsho	6157	38	and	and	CC
cord-006229-7yoilsho	6157	39	metabolized	metabolized	JJ
cord-006229-7yoilsho	6157	40	chemicals	chemical	NNS
cord-006229-7yoilsho	6157	41	.	.	.
cord-006229-7yoilsho	6158	1	Beside	beside	IN
cord-006229-7yoilsho	6158	2	this	this	DT
cord-006229-7yoilsho	6158	3	,	,	,
cord-006229-7yoilsho	6158	4	microRNA	microRNA	NNP
cord-006229-7yoilsho	6158	5	(	(	-LRB-
cord-006229-7yoilsho	6158	6	miRNA	miRNA	NNP
cord-006229-7yoilsho	6158	7	)	)	-RRB-
cord-006229-7yoilsho	6158	8	,	,	,
cord-006229-7yoilsho	6158	9	among	among	IN
cord-006229-7yoilsho	6158	10	them	-PRON-	PRP
cord-006229-7yoilsho	6158	11	those	those	DT
cord-006229-7yoilsho	6158	12	that	that	WDT
cord-006229-7yoilsho	6158	13	can	can	MD
cord-006229-7yoilsho	6158	14	regulate	regulate	VB
cord-006229-7yoilsho	6158	15	DC	DC	NNP
cord-006229-7yoilsho	6158	16	activation	activation	NN
cord-006229-7yoilsho	6158	17	or	or	CC
cord-006229-7yoilsho	6158	18	maturation	maturation	NN
cord-006229-7yoilsho	6158	19	,	,	,
cord-006229-7yoilsho	6158	20	can	can	MD
cord-006229-7yoilsho	6158	21	be	be	VB
cord-006229-7yoilsho	6158	22	differentially	differentially	RB
cord-006229-7yoilsho	6158	23	expressed	express	VBN
cord-006229-7yoilsho	6158	24	upon	upon	IN
cord-006229-7yoilsho	6158	25	stimulation	stimulation	NN
cord-006229-7yoilsho	6158	26	but	but	CC
cord-006229-7yoilsho	6158	27	can	can	MD
cord-006229-7yoilsho	6158	28	also	also	RB
cord-006229-7yoilsho	6158	29	be	be	VB
cord-006229-7yoilsho	6158	30	transferred	transfer	VBN
cord-006229-7yoilsho	6158	31	between	between	IN
cord-006229-7yoilsho	6158	32	cells	cell	NNS
cord-006229-7yoilsho	6158	33	.	.	.
cord-006229-7yoilsho	6159	1	For	for	IN
cord-006229-7yoilsho	6159	2	skin	skin	NN
cord-006229-7yoilsho	6159	3	sensitizers	sensitizer	NNS
cord-006229-7yoilsho	6159	4	,	,	,
cord-006229-7yoilsho	6159	5	we	-PRON-	PRP
cord-006229-7yoilsho	6159	6	reported	report	VBD
cord-006229-7yoilsho	6159	7	already	already	RB
cord-006229-7yoilsho	6159	8	that	that	DT
cord-006229-7yoilsho	6159	9	cross	cross	NN
cord-006229-7yoilsho	6159	10	talk	talk	NN
cord-006229-7yoilsho	6159	11	between	between	IN
cord-006229-7yoilsho	6159	12	HaCaT	HaCaT	NNP
cord-006229-7yoilsho	6159	13	keratinocytes	keratinocyte	NNS
cord-006229-7yoilsho	6159	14	and	and	CC
cord-006229-7yoilsho	6159	15	THP-1	THP-1	NNP
cord-006229-7yoilsho	6159	16	cells	cell	NNS
cord-006229-7yoilsho	6159	17	,	,	,
cord-006229-7yoilsho	6159	18	as	as	IN
cord-006229-7yoilsho	6159	19	model	model	NN
cord-006229-7yoilsho	6159	20	for	for	IN
cord-006229-7yoilsho	6159	21	DC	DC	NNP
cord-006229-7yoilsho	6159	22	,	,	,
cord-006229-7yoilsho	6159	23	enhanced	enhance	VBN
cord-006229-7yoilsho	6159	24	CYP1	CYP1	NNP
cord-006229-7yoilsho	6159	25	enzyme	enzyme	NN
cord-006229-7yoilsho	6159	26	activity	activity	NN
cord-006229-7yoilsho	6159	27	in	in	IN
cord-006229-7yoilsho	6159	28	HaCaT	HaCaT	NNP
cord-006229-7yoilsho	6159	29	cells	cell	NNS
cord-006229-7yoilsho	6159	30	exposed	expose	VBN
cord-006229-7yoilsho	6159	31	to	to	IN
cord-006229-7yoilsho	6159	32	benzo[a]pyrene	benzo[a]pyrene	NN
cord-006229-7yoilsho	6159	33	(	(	-LRB-
cord-006229-7yoilsho	6159	34	B[a]P	B[a]P	NNP
cord-006229-7yoilsho	6159	35	)	)	-RRB-
cord-006229-7yoilsho	6159	36	and	and	CC
cord-006229-7yoilsho	6159	37	eugenol	eugenol	NN
cord-006229-7yoilsho	6159	38	,	,	,
cord-006229-7yoilsho	6159	39	belonging	belong	VBG
cord-006229-7yoilsho	6159	40	to	to	IN
cord-006229-7yoilsho	6159	41	a	a	DT
cord-006229-7yoilsho	6159	42	subgroup	subgroup	NN
cord-006229-7yoilsho	6159	43	of	of	IN
cord-006229-7yoilsho	6159	44	chemicals	chemical	NNS
cord-006229-7yoilsho	6159	45	(	(	-LRB-
cord-006229-7yoilsho	6159	46	prohaptens	prohaptens	NNP
cord-006229-7yoilsho	6159	47	)	)	-RRB-
cord-006229-7yoilsho	6159	48	whose	whose	WP$
cord-006229-7yoilsho	6159	49	sensitizing	sensitize	VBG
cord-006229-7yoilsho	6159	50	potential	potential	JJ
cord-006229-7yoilsho	6159	51	depend	depend	VB
cord-006229-7yoilsho	6159	52	on	on	IN
cord-006229-7yoilsho	6159	53	prior	prior	JJ
cord-006229-7yoilsho	6159	54	metabolic	metabolic	JJ
cord-006229-7yoilsho	6159	55	activation	activation	NN
cord-006229-7yoilsho	6159	56	e.g.	e.g.	RB
cord-006229-7yoilsho	6159	57	via	via	IN
cord-006229-7yoilsho	6159	58	cytochrome	cytochrome	NN
cord-006229-7yoilsho	6159	59	P450	p450	NN
cord-006229-7yoilsho	6159	60	(	(	-LRB-
cord-006229-7yoilsho	6159	61	CYP	CYP	NNP
cord-006229-7yoilsho	6159	62	)	)	-RRB-
cord-006229-7yoilsho	6159	63	enzymes	enzyme	NNS
cord-006229-7yoilsho	6159	64	.	.	.
cord-006229-7yoilsho	6160	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	6160	2	,	,	,
cord-006229-7yoilsho	6160	3	coculture	coculture	NN
cord-006229-7yoilsho	6160	4	clearly	clearly	RB
cord-006229-7yoilsho	6160	5	increased	increase	VBD
cord-006229-7yoilsho	6160	6	the	the	DT
cord-006229-7yoilsho	6160	7	upregulation	upregulation	NN
cord-006229-7yoilsho	6160	8	of	of	IN
cord-006229-7yoilsho	6160	9	the	the	DT
cord-006229-7yoilsho	6160	10	cell	cell	NN
cord-006229-7yoilsho	6160	11	surface	surface	NN
cord-006229-7yoilsho	6160	12	molecule	molecule	NN
cord-006229-7yoilsho	6160	13	CD86	CD86	NNP
cord-006229-7yoilsho	6160	14	on	on	IN
cord-006229-7yoilsho	6160	15	THP-1	THP-1	NNP
cord-006229-7yoilsho	6160	16	cells	cell	NNS
cord-006229-7yoilsho	6160	17	after	after	IN
cord-006229-7yoilsho	6160	18	incubation	incubation	NN
cord-006229-7yoilsho	6160	19	with	with	IN
cord-006229-7yoilsho	6160	20	these	these	DT
cord-006229-7yoilsho	6160	21	prohaptens	prohapten	NNS
cord-006229-7yoilsho	6160	22	and	and	CC
cord-006229-7yoilsho	6160	23	also	also	RB
cord-006229-7yoilsho	6160	24	several	several	JJ
cord-006229-7yoilsho	6160	25	other	other	JJ
cord-006229-7yoilsho	6160	26	skin	skin	NN
cord-006229-7yoilsho	6160	27	sensitizers	sensitizer	NNS
cord-006229-7yoilsho	6160	28	.	.	.
cord-006229-7yoilsho	6161	1	In	in	IN
cord-006229-7yoilsho	6161	2	this	this	DT
cord-006229-7yoilsho	6161	3	study	study	NN
cord-006229-7yoilsho	6161	4	we	-PRON-	PRP
cord-006229-7yoilsho	6161	5	further	further	RB
cord-006229-7yoilsho	6161	6	elucidate	elucidate	VBP
cord-006229-7yoilsho	6161	7	the	the	DT
cord-006229-7yoilsho	6161	8	cross	cross	NN
cord-006229-7yoilsho	6161	9	talk	talk	NN
cord-006229-7yoilsho	6161	10	between	between	IN
cord-006229-7yoilsho	6161	11	THP-1	THP-1	NNP
cord-006229-7yoilsho	6161	12	cells	cell	NNS
cord-006229-7yoilsho	6161	13	and	and	CC
cord-006229-7yoilsho	6161	14	HaCaT	HaCaT	NNP
cord-006229-7yoilsho	6161	15	cells	cell	NNS
cord-006229-7yoilsho	6161	16	by	by	IN
cord-006229-7yoilsho	6161	17	analyzing	analyze	VBG
cord-006229-7yoilsho	6161	18	the	the	DT
cord-006229-7yoilsho	6161	19	impact	impact	NN
cord-006229-7yoilsho	6161	20	of	of	IN
cord-006229-7yoilsho	6161	21	HaCaT	HaCaT	NNP
cord-006229-7yoilsho	6161	22	cells	cell	NNS
cord-006229-7yoilsho	6161	23	on	on	IN
cord-006229-7yoilsho	6161	24	the	the	DT
cord-006229-7yoilsho	6161	25	expression	expression	NN
cord-006229-7yoilsho	6161	26	of	of	IN
cord-006229-7yoilsho	6161	27	miRNAs	miRNAs	NNP
cord-006229-7yoilsho	6161	28	in	in	IN
cord-006229-7yoilsho	6161	29	THP-1	THP-1	NNP
cord-006229-7yoilsho	6161	30	cells	cell	NNS
cord-006229-7yoilsho	6161	31	by	by	IN
cord-006229-7yoilsho	6161	32	Microarray	Microarray	NNP
cord-006229-7yoilsho	6161	33	technology	technology	NN
cord-006229-7yoilsho	6161	34	.	.	.
cord-006229-7yoilsho	6162	1	We	-PRON-	PRP
cord-006229-7yoilsho	6162	2	identified	identify	VBD
cord-006229-7yoilsho	6162	3	6	6	CD
cord-006229-7yoilsho	6162	4	differentially	differentially	RB
cord-006229-7yoilsho	6162	5	expressed	express	VBN
cord-006229-7yoilsho	6162	6	miRNAs	miRNAs	NNP
cord-006229-7yoilsho	6162	7	in	in	IN
cord-006229-7yoilsho	6162	8	cocultured	coculture	VBN
cord-006229-7yoilsho	6162	9	THP-1	THP-1	NNP
cord-006229-7yoilsho	6162	10	cells	cell	NNS
cord-006229-7yoilsho	6162	11	compared	compare	VBN
cord-006229-7yoilsho	6162	12	to	to	IN
cord-006229-7yoilsho	6162	13	monocultured	monocultured	NNP
cord-006229-7yoilsho	6162	14	THP-1	THP-1	NNP
cord-006229-7yoilsho	6162	15	cells	cell	NNS
cord-006229-7yoilsho	6162	16	irrespective	irrespective	RB
cord-006229-7yoilsho	6162	17	of	of	IN
cord-006229-7yoilsho	6162	18	the	the	DT
cord-006229-7yoilsho	6162	19	treatment	treatment	NN
cord-006229-7yoilsho	6162	20	(	(	-LRB-
cord-006229-7yoilsho	6162	21	medium	medium	NN
cord-006229-7yoilsho	6162	22	,	,	,
cord-006229-7yoilsho	6162	23	0.2	0.2	CD
cord-006229-7yoilsho	6162	24	%	%	NN
cord-006229-7yoilsho	6162	25	DMSO	DMSO	NNP
cord-006229-7yoilsho	6162	26	as	as	IN
cord-006229-7yoilsho	6162	27	solvent	solvent	NN
cord-006229-7yoilsho	6162	28	control	control	NN
cord-006229-7yoilsho	6162	29	,	,	,
cord-006229-7yoilsho	6162	30	B[a]P	B[a]P	NNP
cord-006229-7yoilsho	6162	31	)	)	-RRB-
cord-006229-7yoilsho	6162	32	.	.	.
cord-006229-7yoilsho	6163	1	In	in	IN
cord-006229-7yoilsho	6163	2	the	the	DT
cord-006229-7yoilsho	6163	3	presence	presence	NN
cord-006229-7yoilsho	6163	4	of	of	IN
cord-006229-7yoilsho	6163	5	DMSO	DMSO	NNP
cord-006229-7yoilsho	6163	6	and	and	CC
cord-006229-7yoilsho	6163	7	B[a]P	B[a]P	NNP
cord-006229-7yoilsho	6163	8	(	(	-LRB-
cord-006229-7yoilsho	6163	9	after	after	IN
cord-006229-7yoilsho	6163	10	48h	48h	NNS
cord-006229-7yoilsho	6163	11	)	)	-RRB-
cord-006229-7yoilsho	6163	12	8	8	CD
cord-006229-7yoilsho	6163	13	additional	additional	JJ
cord-006229-7yoilsho	6163	14	miRNAs	mirna	NNS
cord-006229-7yoilsho	6163	15	are	be	VBP
cord-006229-7yoilsho	6163	16	differentially	differentially	RB
cord-006229-7yoilsho	6163	17	expressed	express	VBN
cord-006229-7yoilsho	6163	18	.	.	.
cord-006229-7yoilsho	6164	1	Up	up	IN
cord-006229-7yoilsho	6164	2	to	to	IN
cord-006229-7yoilsho	6164	3	now	now	RB
cord-006229-7yoilsho	6164	4	it	-PRON-	PRP
cord-006229-7yoilsho	6164	5	is	be	VBZ
cord-006229-7yoilsho	6164	6	not	not	RB
cord-006229-7yoilsho	6164	7	clear	clear	JJ
cord-006229-7yoilsho	6164	8	whether	whether	IN
cord-006229-7yoilsho	6164	9	the	the	DT
cord-006229-7yoilsho	6164	10	cross	cross	NN
cord-006229-7yoilsho	6164	11	talk	talk	NN
cord-006229-7yoilsho	6164	12	between	between	IN
cord-006229-7yoilsho	6164	13	HaCaT	HaCaT	NNP
cord-006229-7yoilsho	6164	14	and	and	CC
cord-006229-7yoilsho	6164	15	THP-1	THP-1	NNP
cord-006229-7yoilsho	6164	16	cells	cell	NNS
cord-006229-7yoilsho	6164	17	comprises	comprise	VBZ
cord-006229-7yoilsho	6164	18	the	the	DT
cord-006229-7yoilsho	6164	19	exchange	exchange	NN
cord-006229-7yoilsho	6164	20	of	of	IN
cord-006229-7yoilsho	6164	21	miRNA	miRNA	NNP
cord-006229-7yoilsho	6164	22	between	between	IN
cord-006229-7yoilsho	6164	23	the	the	DT
cord-006229-7yoilsho	6164	24	cocultured	cocultured	JJ
cord-006229-7yoilsho	6164	25	cells	cell	NNS
cord-006229-7yoilsho	6164	26	or	or	CC
cord-006229-7yoilsho	6164	27	whether	whether	IN
cord-006229-7yoilsho	6164	28	it	-PRON-	PRP
cord-006229-7yoilsho	6164	29	influences	influence	VBZ
cord-006229-7yoilsho	6164	30	the	the	DT
cord-006229-7yoilsho	6164	31	expression	expression	NN
cord-006229-7yoilsho	6164	32	of	of	IN
cord-006229-7yoilsho	6164	33	these	these	DT
cord-006229-7yoilsho	6164	34	miRNA	miRNA	NNP
cord-006229-7yoilsho	6164	35	in	in	IN
cord-006229-7yoilsho	6164	36	THP-1	THP-1	NNP
cord-006229-7yoilsho	6164	37	cells	cell	NNS
cord-006229-7yoilsho	6164	38	,	,	,
cord-006229-7yoilsho	6164	39	or	or	CC
cord-006229-7yoilsho	6164	40	both	both	DT
cord-006229-7yoilsho	6164	41	.	.	.
cord-006229-7yoilsho	6165	1	Given	give	VBN
cord-006229-7yoilsho	6165	2	that	that	DT
cord-006229-7yoilsho	6165	3	one	one	CD
cord-006229-7yoilsho	6165	4	miRNA	miRNA	NNP
cord-006229-7yoilsho	6165	5	has	have	VBZ
cord-006229-7yoilsho	6165	6	several	several	JJ
cord-006229-7yoilsho	6165	7	gene	gene	NN
cord-006229-7yoilsho	6165	8	targets	target	NNS
cord-006229-7yoilsho	6165	9	these	these	DT
cord-006229-7yoilsho	6165	10	results	result	NNS
cord-006229-7yoilsho	6165	11	illustrate	illustrate	VBP
cord-006229-7yoilsho	6165	12	that	that	IN
cord-006229-7yoilsho	6165	13	the	the	DT
cord-006229-7yoilsho	6165	14	cross	cross	NN
cord-006229-7yoilsho	6165	15	talk	talk	NN
cord-006229-7yoilsho	6165	16	between	between	IN
cord-006229-7yoilsho	6165	17	THP-1	THP-1	NNP
cord-006229-7yoilsho	6165	18	and	and	CC
cord-006229-7yoilsho	6165	19	HaCaT	HaCaT	NNP
cord-006229-7yoilsho	6165	20	cells	cell	NNS
cord-006229-7yoilsho	6165	21	also	also	RB
cord-006229-7yoilsho	6165	22	impacts	impact	VBZ
cord-006229-7yoilsho	6165	23	on	on	IN
cord-006229-7yoilsho	6165	24	the	the	DT
cord-006229-7yoilsho	6165	25	miRNome	miRNome	NNP
cord-006229-7yoilsho	6165	26	.	.	.
cord-006229-7yoilsho	6166	1	Walther	Walther	NNP
cord-006229-7yoilsho	6166	2	-	-	HYPH
cord-006229-7yoilsho	6166	3	Straub	Straub	NNP
cord-006229-7yoilsho	6166	4	-	-	HYPH
cord-006229-7yoilsho	6166	5	Institut	Institut	NNP
cord-006229-7yoilsho	6166	6	der	der	NNP
cord-006229-7yoilsho	6166	7	LMU	LMU	NNP
cord-006229-7yoilsho	6166	8	-	-	HYPH
cord-006229-7yoilsho	6166	9	München	München	NNP
cord-006229-7yoilsho	6166	10	,	,	,
cord-006229-7yoilsho	6166	11	München	München	NNP
cord-006229-7yoilsho	6166	12	,	,	,
cord-006229-7yoilsho	6166	13	Germany	Germany	NNP
cord-006229-7yoilsho	6166	14	Transient	Transient	NNP
cord-006229-7yoilsho	6166	15	Receptor	Receptor	NNP
cord-006229-7yoilsho	6166	16	Potential	Potential	NNP
cord-006229-7yoilsho	6166	17	(	(	-LRB-
cord-006229-7yoilsho	6166	18	TRP	TRP	NNP
cord-006229-7yoilsho	6166	19	)	)	-RRB-
cord-006229-7yoilsho	6166	20	proteins	protein	NNS
cord-006229-7yoilsho	6166	21	represent	represent	VBP
cord-006229-7yoilsho	6166	22	a	a	DT
cord-006229-7yoilsho	6166	23	large	large	JJ
cord-006229-7yoilsho	6166	24	superfamily	superfamily	NN
cord-006229-7yoilsho	6166	25	of	of	IN
cord-006229-7yoilsho	6166	26	nonselective	nonselective	JJ
cord-006229-7yoilsho	6166	27	cation	cation	NN
cord-006229-7yoilsho	6166	28	channels	channel	NNS
cord-006229-7yoilsho	6166	29	sensing	sense	VBG
cord-006229-7yoilsho	6166	30	toxic	toxic	JJ
cord-006229-7yoilsho	6166	31	stimuli	stimulus	NNS
cord-006229-7yoilsho	6166	32	in	in	IN
cord-006229-7yoilsho	6166	33	the	the	DT
cord-006229-7yoilsho	6166	34	human	human	JJ
cord-006229-7yoilsho	6166	35	body	body	NN
cord-006229-7yoilsho	6166	36	.	.	.
cord-006229-7yoilsho	6167	1	TRPA1	trpa1	NN
cord-006229-7yoilsho	6167	2	expresses	express	VBZ
cord-006229-7yoilsho	6167	3	a	a	DT
cord-006229-7yoilsho	6167	4	high	high	JJ
cord-006229-7yoilsho	6167	5	number	number	NN
cord-006229-7yoilsho	6167	6	of	of	IN
cord-006229-7yoilsho	6167	7	aminoterminal	aminoterminal	JJ
cord-006229-7yoilsho	6167	8	ankyrin	ankyrin	NNP
cord-006229-7yoilsho	6167	9	repeats	repeat	VBZ
cord-006229-7yoilsho	6167	10	and	and	CC
cord-006229-7yoilsho	6167	11	is	be	VBZ
cord-006229-7yoilsho	6167	12	the	the	DT
cord-006229-7yoilsho	6167	13	only	only	JJ
cord-006229-7yoilsho	6167	14	member	member	NN
cord-006229-7yoilsho	6167	15	of	of	IN
cord-006229-7yoilsho	6167	16	the	the	DT
cord-006229-7yoilsho	6167	17	TRPA	TRPA	NNP
cord-006229-7yoilsho	6167	18	family	family	NN
cord-006229-7yoilsho	6167	19	.	.	.
cord-006229-7yoilsho	6168	1	Channel	Channel	NNP
cord-006229-7yoilsho	6168	2	monomers	monomer	NNS
cord-006229-7yoilsho	6168	3	form	form	VBP
cord-006229-7yoilsho	6168	4	homotetramers	homotetramer	NNS
cord-006229-7yoilsho	6168	5	in	in	IN
cord-006229-7yoilsho	6168	6	the	the	DT
cord-006229-7yoilsho	6168	7	plasma	plasma	NN
cord-006229-7yoilsho	6168	8	membrane	membrane	NN
cord-006229-7yoilsho	6168	9	with	with	IN
cord-006229-7yoilsho	6168	10	six	six	CD
cord-006229-7yoilsho	6168	11	transmembrane	transmembrane	NN
cord-006229-7yoilsho	6168	12	segments	segment	NNS
cord-006229-7yoilsho	6168	13	(	(	-LRB-
cord-006229-7yoilsho	6168	14	TM	TM	NNP
cord-006229-7yoilsho	6168	15	)	)	-RRB-
cord-006229-7yoilsho	6168	16	and	and	CC
cord-006229-7yoilsho	6168	17	a	a	DT
cord-006229-7yoilsho	6168	18	pore	pore	NN
cord-006229-7yoilsho	6168	19	forming	form	VBG
cord-006229-7yoilsho	6168	20	loop	loop	NN
cord-006229-7yoilsho	6168	21	between	between	IN
cord-006229-7yoilsho	6168	22	TM5	TM5	NNP
cord-006229-7yoilsho	6168	23	and	and	CC
cord-006229-7yoilsho	6168	24	6	6	CD
cord-006229-7yoilsho	6168	25	.	.	.
cord-006229-7yoilsho	6169	1	TRPA1	trpa1	NN
cord-006229-7yoilsho	6169	2	has	have	VBZ
cord-006229-7yoilsho	6169	3	been	be	VBN
cord-006229-7yoilsho	6169	4	extensively	extensively	RB
cord-006229-7yoilsho	6169	5	described	describe	VBN
cord-006229-7yoilsho	6169	6	in	in	IN
cord-006229-7yoilsho	6169	7	sensory	sensory	JJ
cord-006229-7yoilsho	6169	8	nerve	nerve	NN
cord-006229-7yoilsho	6169	9	endings	ending	NNS
cord-006229-7yoilsho	6169	10	as	as	IN
cord-006229-7yoilsho	6169	11	an	an	DT
cord-006229-7yoilsho	6169	12	important	important	JJ
cord-006229-7yoilsho	6169	13	cellular	cellular	JJ
cord-006229-7yoilsho	6169	14	detector	detector	NN
cord-006229-7yoilsho	6169	15	for	for	IN
cord-006229-7yoilsho	6169	16	toxic	toxic	JJ
cord-006229-7yoilsho	6169	17	stimuli	stimulus	NNS
cord-006229-7yoilsho	6169	18	and	and	CC
cord-006229-7yoilsho	6169	19	as	as	IN
cord-006229-7yoilsho	6169	20	an	an	DT
cord-006229-7yoilsho	6169	21	oxygen	oxygen	NN
cord-006229-7yoilsho	6169	22	sensor	sensor	NN
cord-006229-7yoilsho	6169	23	(	(	-LRB-
cord-006229-7yoilsho	6169	24	reviewed	review	VBN
cord-006229-7yoilsho	6169	25	in	in	IN
cord-006229-7yoilsho	6169	26	1	1	CD
cord-006229-7yoilsho	6169	27	)	)	-RRB-
cord-006229-7yoilsho	6169	28	.	.	.
cord-006229-7yoilsho	6170	1	Although	although	IN
cord-006229-7yoilsho	6170	2	recently	recently	RB
cord-006229-7yoilsho	6170	3	two	two	CD
cord-006229-7yoilsho	6170	4	reports	report	NNS
cord-006229-7yoilsho	6170	5	identified	identify	VBD
cord-006229-7yoilsho	6170	6	TRPA1	trpa1	NN
cord-006229-7yoilsho	6170	7	in	in	IN
cord-006229-7yoilsho	6170	8	pulmonary	pulmonary	JJ
cord-006229-7yoilsho	6170	9	epithelial	epithelial	NN
cord-006229-7yoilsho	6170	10	and	and	CC
cord-006229-7yoilsho	6170	11	endothelial	endothelial	JJ
cord-006229-7yoilsho	6170	12	cells	cell	NNS
cord-006229-7yoilsho	6170	13	(	(	-LRB-
cord-006229-7yoilsho	6170	14	2	2	CD
cord-006229-7yoilsho	6170	15	,	,	,
cord-006229-7yoilsho	6170	16	3	3	CD
cord-006229-7yoilsho	6170	17	)	)	-RRB-
cord-006229-7yoilsho	6170	18	,	,	,
cord-006229-7yoilsho	6170	19	its	-PRON-	PRP$
cord-006229-7yoilsho	6170	20	expression	expression	NN
cord-006229-7yoilsho	6170	21	in	in	IN
cord-006229-7yoilsho	6170	22	non	non	JJ
cord-006229-7yoilsho	6170	23	-	-	JJ
cord-006229-7yoilsho	6170	24	neuronal	neuronal	JJ
cord-006229-7yoilsho	6170	25	tissues	tissue	NNS
cord-006229-7yoilsho	6170	26	is	be	VBZ
cord-006229-7yoilsho	6170	27	still	still	RB
cord-006229-7yoilsho	6170	28	a	a	DT
cord-006229-7yoilsho	6170	29	matter	matter	NN
cord-006229-7yoilsho	6170	30	of	of	IN
cord-006229-7yoilsho	6170	31	debate	debate	NN
cord-006229-7yoilsho	6170	32	.	.	.
cord-006229-7yoilsho	6171	1	After	after	IN
cord-006229-7yoilsho	6171	2	isolation	isolation	NN
cord-006229-7yoilsho	6171	3	and	and	CC
cord-006229-7yoilsho	6171	4	identification	identification	NN
cord-006229-7yoilsho	6171	5	of	of	IN
cord-006229-7yoilsho	6171	6	different	different	JJ
cord-006229-7yoilsho	6171	7	murine	murine	JJ
cord-006229-7yoilsho	6171	8	lung	lung	NN
cord-006229-7yoilsho	6171	9	cells	cell	NNS
cord-006229-7yoilsho	6171	10	we	-PRON-	PRP
cord-006229-7yoilsho	6171	11	were	be	VBD
cord-006229-7yoilsho	6171	12	able	able	JJ
cord-006229-7yoilsho	6171	13	to	to	TO
cord-006229-7yoilsho	6171	14	identify	identify	VB
cord-006229-7yoilsho	6171	15	murine	murine	JJ
cord-006229-7yoilsho	6171	16	TRPA1	trpa1	DT
cord-006229-7yoilsho	6171	17	protein	protein	NN
cord-006229-7yoilsho	6171	18	in	in	IN
cord-006229-7yoilsho	6171	19	primary	primary	JJ
cord-006229-7yoilsho	6171	20	endothelial	endothelial	JJ
cord-006229-7yoilsho	6171	21	cells	cell	NNS
cord-006229-7yoilsho	6171	22	,	,	,
cord-006229-7yoilsho	6171	23	pneumocytes	pneumocyte	NNS
cord-006229-7yoilsho	6171	24	type	type	NN
cord-006229-7yoilsho	6171	25	II	II	NNP
cord-006229-7yoilsho	6171	26	(	(	-LRB-
cord-006229-7yoilsho	6171	27	ATII	ATII	NNP
cord-006229-7yoilsho	6171	28	)	)	-RRB-
cord-006229-7yoilsho	6171	29	and	and	CC
cord-006229-7yoilsho	6171	30	fibroblasts	fibroblast	NNS
cord-006229-7yoilsho	6171	31	by	by	IN
cord-006229-7yoilsho	6171	32	using	use	VBG
cord-006229-7yoilsho	6171	33	specific	specific	JJ
cord-006229-7yoilsho	6171	34	antibodies	antibody	NNS
cord-006229-7yoilsho	6171	35	in	in	IN
cord-006229-7yoilsho	6171	36	a	a	DT
cord-006229-7yoilsho	6171	37	western	western	JJ
cord-006229-7yoilsho	6171	38	blot	blot	NN
cord-006229-7yoilsho	6171	39	analysis	analysis	NN
cord-006229-7yoilsho	6171	40	,	,	,
cord-006229-7yoilsho	6171	41	but	but	CC
cord-006229-7yoilsho	6171	42	not	not	RB
cord-006229-7yoilsho	6171	43	in	in	IN
cord-006229-7yoilsho	6171	44	cells	cell	NNS
cord-006229-7yoilsho	6171	45	from	from	IN
cord-006229-7yoilsho	6171	46	TRPA1-deficient	trpa1-deficient	CD
cord-006229-7yoilsho	6171	47	mice	mouse	NNS
cord-006229-7yoilsho	6171	48	.	.	.
cord-006229-7yoilsho	6172	1	ATII	ATII	NNP
cord-006229-7yoilsho	6172	2	cells	cell	NNS
cord-006229-7yoilsho	6172	3	were	be	VBD
cord-006229-7yoilsho	6172	4	identified	identify	VBN
cord-006229-7yoilsho	6172	5	by	by	IN
cord-006229-7yoilsho	6172	6	specific	specific	JJ
cord-006229-7yoilsho	6172	7	cell	cell	NN
cord-006229-7yoilsho	6172	8	markers	marker	NNS
cord-006229-7yoilsho	6172	9	such	such	JJ
cord-006229-7yoilsho	6172	10	as	as	IN
cord-006229-7yoilsho	6172	11	surfactant	surfactant	NN
cord-006229-7yoilsho	6172	12	protein	protein	NN
cord-006229-7yoilsho	6172	13	C	c	NN
cord-006229-7yoilsho	6172	14	and	and	CC
cord-006229-7yoilsho	6172	15	were	be	VBD
cord-006229-7yoilsho	6172	16	further	further	RB
cord-006229-7yoilsho	6172	17	differentiated	differentiate	VBN
cord-006229-7yoilsho	6172	18	to	to	IN
cord-006229-7yoilsho	6172	19	ATI	ATI	NNP
cord-006229-7yoilsho	6172	20	cells	cell	NNS
cord-006229-7yoilsho	6172	21	characterized	characterize	VBN
cord-006229-7yoilsho	6172	22	by	by	IN
cord-006229-7yoilsho	6172	23	their	-PRON-	PRP$
cord-006229-7yoilsho	6172	24	specific	specific	JJ
cord-006229-7yoilsho	6172	25	expression	expression	NN
cord-006229-7yoilsho	6172	26	of	of	IN
cord-006229-7yoilsho	6172	27	podoplanin	podoplanin	NNS
cord-006229-7yoilsho	6172	28	.	.	.
cord-006229-7yoilsho	6173	1	Quantitative	quantitative	JJ
cord-006229-7yoilsho	6173	2	TRP	TRP	NNP
cord-006229-7yoilsho	6173	3	expression	expression	NN
cord-006229-7yoilsho	6173	4	patterns	pattern	NNS
cord-006229-7yoilsho	6173	5	will	will	MD
cord-006229-7yoilsho	6173	6	now	now	RB
cord-006229-7yoilsho	6173	7	be	be	VB
cord-006229-7yoilsho	6173	8	evaluated	evaluate	VBN
cord-006229-7yoilsho	6173	9	by	by	IN
cord-006229-7yoilsho	6173	10	quantitative	quantitative	JJ
cord-006229-7yoilsho	6173	11	reverse	reverse	NN
cord-006229-7yoilsho	6173	12	transcription	transcription	NN
cord-006229-7yoilsho	6173	13	(	(	-LRB-
cord-006229-7yoilsho	6173	14	RT)-PCR	rt)-pcr	XX
cord-006229-7yoilsho	6173	15	as	as	RB
cord-006229-7yoilsho	6173	16	well	well	RB
cord-006229-7yoilsho	6173	17	as	as	IN
cord-006229-7yoilsho	6173	18	utilizing	utilize	VBG
cord-006229-7yoilsho	6173	19	NanoString	NanoString	NNP
cord-006229-7yoilsho	6173	20	®	®	POS
cord-006229-7yoilsho	6173	21	technology	technology	NN
cord-006229-7yoilsho	6173	22	in	in	IN
cord-006229-7yoilsho	6173	23	different	different	JJ
cord-006229-7yoilsho	6173	24	lung	lung	NN
cord-006229-7yoilsho	6173	25	cells	cell	NNS
cord-006229-7yoilsho	6173	26	.	.	.
cord-006229-7yoilsho	6174	1	To	to	TO
cord-006229-7yoilsho	6174	2	characterize	characterize	VB
cord-006229-7yoilsho	6174	3	TRPA1	trpa1	NN
cord-006229-7yoilsho	6174	4	on	on	IN
cord-006229-7yoilsho	6174	5	a	a	DT
cord-006229-7yoilsho	6174	6	cellular	cellular	JJ
cord-006229-7yoilsho	6174	7	level	level	NN
cord-006229-7yoilsho	6174	8	we	-PRON-	PRP
cord-006229-7yoilsho	6174	9	cultured	culture	VBD
cord-006229-7yoilsho	6174	10	a	a	DT
cord-006229-7yoilsho	6174	11	HEK293	HEK293	NNP
cord-006229-7yoilsho	6174	12	cell	cell	NN
cord-006229-7yoilsho	6174	13	line	line	NN
cord-006229-7yoilsho	6174	14	stably	stably	RB
cord-006229-7yoilsho	6174	15	expressing	express	VBG
cord-006229-7yoilsho	6174	16	TRPA1	trpa1	NN
cord-006229-7yoilsho	6174	17	(	(	-LRB-
cord-006229-7yoilsho	6174	18	4	4	CD
cord-006229-7yoilsho	6174	19	)	)	-RRB-
cord-006229-7yoilsho	6174	20	.	.	.
cord-006229-7yoilsho	6175	1	Allylisothiocyanate	Allylisothiocyanate	NNP
cord-006229-7yoilsho	6175	2	(	(	-LRB-
cord-006229-7yoilsho	6175	3	AITC	AITC	NNP
cord-006229-7yoilsho	6175	4	)	)	-RRB-
cord-006229-7yoilsho	6175	5	a	a	DT
cord-006229-7yoilsho	6175	6	specific	specific	JJ
cord-006229-7yoilsho	6175	7	activator	activator	NN
cord-006229-7yoilsho	6175	8	as	as	RB
cord-006229-7yoilsho	6175	9	well	well	RB
cord-006229-7yoilsho	6175	10	as	as	IN
cord-006229-7yoilsho	6175	11	hypoxia	hypoxia	NN
cord-006229-7yoilsho	6175	12	and	and	CC
cord-006229-7yoilsho	6175	13	hyperoxia	hyperoxia	NN
cord-006229-7yoilsho	6175	14	was	be	VBD
cord-006229-7yoilsho	6175	15	able	able	JJ
cord-006229-7yoilsho	6175	16	to	to	TO
cord-006229-7yoilsho	6175	17	induce	induce	VB
cord-006229-7yoilsho	6175	18	Ca	Ca	NNP
cord-006229-7yoilsho	6175	19	2	2	CD
cord-006229-7yoilsho	6175	20	+	+	CD
cord-006229-7yoilsho	6176	1	-influx	-influx	.
cord-006229-7yoilsho	6177	1	in	in	IN
cord-006229-7yoilsho	6177	2	this	this	DT
cord-006229-7yoilsho	6177	3	cell	cell	NN
cord-006229-7yoilsho	6177	4	line	line	NN
cord-006229-7yoilsho	6177	5	,	,	,
cord-006229-7yoilsho	6177	6	which	which	WDT
cord-006229-7yoilsho	6177	7	was	be	VBD
cord-006229-7yoilsho	6177	8	blocked	block	VBN
cord-006229-7yoilsho	6177	9	by	by	IN
cord-006229-7yoilsho	6177	10	the	the	DT
cord-006229-7yoilsho	6177	11	specific	specific	JJ
cord-006229-7yoilsho	6177	12	inhibitor	inhibitor	NN
cord-006229-7yoilsho	6177	13	A96079	a96079	NN
cord-006229-7yoilsho	6177	14	.	.	.
cord-006229-7yoilsho	6178	1	In	in	IN
cord-006229-7yoilsho	6178	2	the	the	DT
cord-006229-7yoilsho	6178	3	future	future	NN
cord-006229-7yoilsho	6178	4	,	,	,
cord-006229-7yoilsho	6178	5	we	-PRON-	PRP
cord-006229-7yoilsho	6178	6	will	will	MD
cord-006229-7yoilsho	6178	7	utilize	utilize	VB
cord-006229-7yoilsho	6178	8	the	the	DT
cord-006229-7yoilsho	6178	9	isolated	isolate	VBN
cord-006229-7yoilsho	6178	10	perfused	perfuse	VBN
cord-006229-7yoilsho	6178	11	lung	lung	NN
cord-006229-7yoilsho	6178	12	model	model	NN
cord-006229-7yoilsho	6178	13	(	(	-LRB-
cord-006229-7yoilsho	6178	14	5	5	CD
cord-006229-7yoilsho	6178	15	)	)	-RRB-
cord-006229-7yoilsho	6178	16	to	to	TO
cord-006229-7yoilsho	6178	17	quantify	quantify	VB
cord-006229-7yoilsho	6178	18	toxin	toxin	NN
cord-006229-7yoilsho	6178	19	-	-	HYPH
cord-006229-7yoilsho	6178	20	induced	induce	VBN
cord-006229-7yoilsho	6178	21	edema	edema	NN
cord-006229-7yoilsho	6178	22	formation	formation	NN
cord-006229-7yoilsho	6178	23	in	in	IN
cord-006229-7yoilsho	6178	24	ex	ex	FW
cord-006229-7yoilsho	6178	25	vivo	vivo	NN
cord-006229-7yoilsho	6178	26	lungs	lung	NNS
cord-006229-7yoilsho	6178	27	from	from	IN
cord-006229-7yoilsho	6178	28	WT	WT	NNP
cord-006229-7yoilsho	6178	29	and	and	CC
cord-006229-7yoilsho	6178	30	TRPA1-deficient	TRPA1-deficient	NNP
cord-006229-7yoilsho	6178	31	mice	mouse	NNS
cord-006229-7yoilsho	6178	32	after	after	IN
cord-006229-7yoilsho	6178	33	exposure	exposure	NN
cord-006229-7yoilsho	6178	34	to	to	IN
cord-006229-7yoilsho	6178	35	potential	potential	JJ
cord-006229-7yoilsho	6178	36	toxic	toxic	JJ
cord-006229-7yoilsho	6178	37	inhalation	inhalation	NN
cord-006229-7yoilsho	6178	38	hazards	hazard	NNS
cord-006229-7yoilsho	6178	39	(	(	-LRB-
cord-006229-7yoilsho	6178	40	TIH	TIH	NNP
cord-006229-7yoilsho	6178	41	see	see	VBP
cord-006229-7yoilsho	6178	42	6	6	CD
cord-006229-7yoilsho	6178	43	)	)	-RRB-
cord-006229-7yoilsho	6178	44	to	to	TO
cord-006229-7yoilsho	6178	45	challenge	challenge	VB
cord-006229-7yoilsho	6178	46	the	the	DT
cord-006229-7yoilsho	6178	47	hypothesis	hypothesis	NN
cord-006229-7yoilsho	6178	48	of	of	IN
cord-006229-7yoilsho	6178	49	TRPA1	trpa1	NN
cord-006229-7yoilsho	6178	50	as	as	IN
cord-006229-7yoilsho	6178	51	an	an	DT
cord-006229-7yoilsho	6178	52	important	important	JJ
cord-006229-7yoilsho	6178	53	toxin	toxin	NN
cord-006229-7yoilsho	6178	54	sensor	sensor	NN
cord-006229-7yoilsho	6178	55	in	in	IN
cord-006229-7yoilsho	6178	56	the	the	DT
cord-006229-7yoilsho	6178	57	lung	lung	NN
cord-006229-7yoilsho	6178	58	.	.	.
cord-006229-7yoilsho	6179	1	By	by	IN
cord-006229-7yoilsho	6179	2	this	this	DT
cord-006229-7yoilsho	6179	3	strategy	strategy	NN
cord-006229-7yoilsho	6179	4	we	-PRON-	PRP
cord-006229-7yoilsho	6179	5	hope	hope	VBP
cord-006229-7yoilsho	6179	6	to	to	TO
cord-006229-7yoilsho	6179	7	understand	understand	VB
cord-006229-7yoilsho	6179	8	TRPA1	trpa1	DT
cord-006229-7yoilsho	6179	9	function	function	NN
cord-006229-7yoilsho	6179	10	in	in	IN
cord-006229-7yoilsho	6179	11	lung	lung	NN
cord-006229-7yoilsho	6179	12	cells	cell	NNS
cord-006229-7yoilsho	6179	13	and	and	CC
cord-006229-7yoilsho	6179	14	to	to	TO
cord-006229-7yoilsho	6179	15	evaluate	evaluate	VB
cord-006229-7yoilsho	6179	16	TRPA1	trpa1	NN
cord-006229-7yoilsho	6179	17	proteins	protein	NNS
cord-006229-7yoilsho	6179	18	as	as	IN
cord-006229-7yoilsho	6179	19	potential	potential	JJ
cord-006229-7yoilsho	6179	20	pharmacological	pharmacological	JJ
cord-006229-7yoilsho	6179	21	targets	target	NNS
cord-006229-7yoilsho	6179	22	for	for	IN
cord-006229-7yoilsho	6179	23	a	a	DT
cord-006229-7yoilsho	6179	24	specific	specific	JJ
cord-006229-7yoilsho	6179	25	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	6179	26	intervention	intervention	NN
cord-006229-7yoilsho	6179	27	during	during	IN
cord-006229-7yoilsho	6179	28	toxin	toxin	NN
cord-006229-7yoilsho	6179	29	-	-	HYPH
cord-006229-7yoilsho	6179	30	induced	induce	VBN
cord-006229-7yoilsho	6179	31	edema	edema	NN
cord-006229-7yoilsho	6179	32	formation	formation	NN
cord-006229-7yoilsho	6179	33	.	.	.
cord-006229-7yoilsho	6180	1	Metabolism	metabolism	NN
cord-006229-7yoilsho	6180	2	by	by	IN
cord-006229-7yoilsho	6180	3	the	the	DT
cord-006229-7yoilsho	6180	4	intestinal	intestinal	JJ
cord-006229-7yoilsho	6180	5	microbiota	microbiota	NN
cord-006229-7yoilsho	6180	6	is	be	VBZ
cord-006229-7yoilsho	6180	7	likely	likely	JJ
cord-006229-7yoilsho	6180	8	to	to	TO
cord-006229-7yoilsho	6180	9	contribute	contribute	VB
cord-006229-7yoilsho	6180	10	essentially	essentially	RB
cord-006229-7yoilsho	6180	11	to	to	IN
cord-006229-7yoilsho	6180	12	the	the	DT
cord-006229-7yoilsho	6180	13	plasma	plasma	NN
cord-006229-7yoilsho	6180	14	metabolite	metabolite	NN
cord-006229-7yoilsho	6180	15	profile	profile	NN
cord-006229-7yoilsho	6180	16	of	of	IN
cord-006229-7yoilsho	6180	17	the	the	DT
cord-006229-7yoilsho	6180	18	mammalian	mammalian	JJ
cord-006229-7yoilsho	6180	19	host	host	NN
cord-006229-7yoilsho	6180	20	organism	organism	NN
cord-006229-7yoilsho	6180	21	and	and	CC
cord-006229-7yoilsho	6180	22	it	-PRON-	PRP
cord-006229-7yoilsho	6180	23	requires	require	VBZ
cord-006229-7yoilsho	6180	24	adequate	adequate	JJ
cord-006229-7yoilsho	6180	25	identification	identification	NN
cord-006229-7yoilsho	6180	26	of	of	IN
cord-006229-7yoilsho	6180	27	effects	effect	NNS
cord-006229-7yoilsho	6180	28	of	of	IN
cord-006229-7yoilsho	6180	29	the	the	DT
cord-006229-7yoilsho	6180	30	microbiome	microbiome	NN
cord-006229-7yoilsho	6180	31	on	on	IN
cord-006229-7yoilsho	6180	32	the	the	DT
cord-006229-7yoilsho	6180	33	endogenous	endogenous	JJ
cord-006229-7yoilsho	6180	34	plasma	plasma	NN
cord-006229-7yoilsho	6180	35	metabolite	metabolite	NN
cord-006229-7yoilsho	6180	36	patterns	pattern	NNS
cord-006229-7yoilsho	6180	37	.	.	.
cord-006229-7yoilsho	6181	1	The	the	DT
cord-006229-7yoilsho	6181	2	current	current	JJ
cord-006229-7yoilsho	6181	3	investigations	investigation	NNS
cord-006229-7yoilsho	6181	4	present	present	VBP
cord-006229-7yoilsho	6181	5	insights	insight	NNS
cord-006229-7yoilsho	6181	6	in	in	IN
cord-006229-7yoilsho	6181	7	the	the	DT
cord-006229-7yoilsho	6181	8	mammalian	mammalian	JJ
cord-006229-7yoilsho	6181	9	-	-	HYPH
cord-006229-7yoilsho	6181	10	microbiome	microbiome	NN
cord-006229-7yoilsho	6181	11	cometabolism	cometabolism	NN
cord-006229-7yoilsho	6181	12	of	of	IN
cord-006229-7yoilsho	6181	13	endogenous	endogenous	JJ
cord-006229-7yoilsho	6181	14	metabolites	metabolite	NNS
cord-006229-7yoilsho	6181	15	.	.	.
cord-006229-7yoilsho	6182	1	Antibiotics	antibiotic	NNS
cord-006229-7yoilsho	6182	2	have	have	VBP
cord-006229-7yoilsho	6182	3	a	a	DT
cord-006229-7yoilsho	6182	4	profound	profound	JJ
cord-006229-7yoilsho	6182	5	effect	effect	NN
cord-006229-7yoilsho	6182	6	on	on	IN
cord-006229-7yoilsho	6182	7	the	the	DT
cord-006229-7yoilsho	6182	8	micro	micro	JJ
cord-006229-7yoilsho	6182	9	-	-	JJ
cord-006229-7yoilsho	6182	10	organism	organism	JJ
cord-006229-7yoilsho	6182	11	composition	composition	NN
cord-006229-7yoilsho	6182	12	of	of	IN
cord-006229-7yoilsho	6182	13	the	the	DT
cord-006229-7yoilsho	6182	14	microbiome	microbiome	NN
cord-006229-7yoilsho	6182	15	and	and	CC
cord-006229-7yoilsho	6182	16	hence	hence	RB
cord-006229-7yoilsho	6182	17	on	on	IN
cord-006229-7yoilsho	6182	18	the	the	DT
cord-006229-7yoilsho	6182	19	mammalian	mammalian	JJ
cord-006229-7yoilsho	6182	20	-	-	HYPH
cord-006229-7yoilsho	6182	21	microbiome	microbiome	NN
cord-006229-7yoilsho	6182	22	co	co	NN
cord-006229-7yoilsho	6182	23	-	-	NN
cord-006229-7yoilsho	6182	24	metabolism	metabolism	NN
cord-006229-7yoilsho	6182	25	.	.	.
cord-006229-7yoilsho	6183	1	The	the	DT
cord-006229-7yoilsho	6183	2	consequences	consequence	NNS
cord-006229-7yoilsho	6183	3	,	,	,
cord-006229-7yoilsho	6183	4	however	however	RB
cord-006229-7yoilsho	6183	5	,	,	,
cord-006229-7yoilsho	6183	6	on	on	IN
cord-006229-7yoilsho	6183	7	the	the	DT
cord-006229-7yoilsho	6183	8	functionality	functionality	NN
cord-006229-7yoilsho	6183	9	of	of	IN
cord-006229-7yoilsho	6183	10	the	the	DT
cord-006229-7yoilsho	6183	11	microbiome	microbiome	NN
cord-006229-7yoilsho	6183	12	(	(	-LRB-
cord-006229-7yoilsho	6183	13	defined	define	VBN
cord-006229-7yoilsho	6183	14	as	as	IN
cord-006229-7yoilsho	6183	15	the	the	DT
cord-006229-7yoilsho	6183	16	production	production	NN
cord-006229-7yoilsho	6183	17	of	of	IN
cord-006229-7yoilsho	6183	18	metabolites	metabolite	NNS
cord-006229-7yoilsho	6183	19	absorbed	absorb	VBN
cord-006229-7yoilsho	6183	20	by	by	IN
cord-006229-7yoilsho	6183	21	the	the	DT
cord-006229-7yoilsho	6183	22	host	host	NN
cord-006229-7yoilsho	6183	23	)	)	-RRB-
cord-006229-7yoilsho	6183	24	and	and	CC
cord-006229-7yoilsho	6183	25	which	which	WDT
cord-006229-7yoilsho	6183	26	of	of	IN
cord-006229-7yoilsho	6183	27	these	these	DT
cord-006229-7yoilsho	6183	28	changes	change	NNS
cord-006229-7yoilsho	6183	29	are	be	VBP
cord-006229-7yoilsho	6183	30	related	relate	VBN
cord-006229-7yoilsho	6183	31	to	to	IN
cord-006229-7yoilsho	6183	32	the	the	DT
cord-006229-7yoilsho	6183	33	microbiome	microbiome	NN
cord-006229-7yoilsho	6183	34	are	be	VBP
cord-006229-7yoilsho	6183	35	not	not	RB
cord-006229-7yoilsho	6183	36	well	well	RB
cord-006229-7yoilsho	6183	37	understood	understand	VBN
cord-006229-7yoilsho	6183	38	.	.	.
cord-006229-7yoilsho	6184	1	To	to	TO
cord-006229-7yoilsho	6184	2	identify	identify	VB
cord-006229-7yoilsho	6184	3	plasma	plasma	NN
cord-006229-7yoilsho	6184	4	metabolites	metabolite	NNS
cord-006229-7yoilsho	6184	5	related	relate	VBN
cord-006229-7yoilsho	6184	6	to	to	IN
cord-006229-7yoilsho	6184	7	microbiome	microbiome	NN
cord-006229-7yoilsho	6184	8	changes	change	NNS
cord-006229-7yoilsho	6184	9	due	due	JJ
cord-006229-7yoilsho	6184	10	to	to	IN
cord-006229-7yoilsho	6184	11	antibiotic	antibiotic	JJ
cord-006229-7yoilsho	6184	12	treatment	treatment	NN
cord-006229-7yoilsho	6184	13	,	,	,
cord-006229-7yoilsho	6184	14	we	-PRON-	PRP
cord-006229-7yoilsho	6184	15	have	have	VBP
cord-006229-7yoilsho	6184	16	employed	employ	VBN
cord-006229-7yoilsho	6184	17	a	a	DT
cord-006229-7yoilsho	6184	18	metabolomics	metabolomics	NN
cord-006229-7yoilsho	6184	19	approach	approach	NN
cord-006229-7yoilsho	6184	20	.	.	.
cord-006229-7yoilsho	6185	1	To	to	IN
cord-006229-7yoilsho	6185	2	this	this	DT
cord-006229-7yoilsho	6185	3	purpose	purpose	NN
cord-006229-7yoilsho	6185	4	broadspectrum	broadspectrum	NNP
cord-006229-7yoilsho	6185	5	antibiotics	antibiotic	NNS
cord-006229-7yoilsho	6185	6	belonging	belong	VBG
cord-006229-7yoilsho	6185	7	to	to	IN
cord-006229-7yoilsho	6185	8	the	the	DT
cord-006229-7yoilsho	6185	9	class	class	NN
cord-006229-7yoilsho	6185	10	of	of	IN
cord-006229-7yoilsho	6185	11	aminoglycosides	aminoglycoside	NNS
cord-006229-7yoilsho	6185	12	(	(	-LRB-
cord-006229-7yoilsho	6185	13	streptomycin	streptomycin	NNS
cord-006229-7yoilsho	6185	14	,	,	,
cord-006229-7yoilsho	6185	15	neomycin	neomycin	NN
cord-006229-7yoilsho	6185	16	,	,	,
cord-006229-7yoilsho	6185	17	gentamicin	gentamicin	NNP
cord-006229-7yoilsho	6185	18	)	)	-RRB-
cord-006229-7yoilsho	6185	19	,	,	,
cord-006229-7yoilsho	6185	20	fluoroquinolones	fluoroquinolone	NNS
cord-006229-7yoilsho	6185	21	(	(	-LRB-
cord-006229-7yoilsho	6185	22	moxifloxacin	moxifloxacin	NNS
cord-006229-7yoilsho	6185	23	,	,	,
cord-006229-7yoilsho	6185	24	levofloxacin	levofloxacin	NNP
cord-006229-7yoilsho	6185	25	)	)	-RRB-
cord-006229-7yoilsho	6185	26	and	and	CC
cord-006229-7yoilsho	6185	27	tetracyclines	tetracycline	NNS
cord-006229-7yoilsho	6185	28	(	(	-LRB-
cord-006229-7yoilsho	6185	29	doxycycline	doxycycline	NNP
cord-006229-7yoilsho	6185	30	,	,	,
cord-006229-7yoilsho	6185	31	tetracycline	tetracycline	NNP
cord-006229-7yoilsho	6185	32	)	)	-RRB-
cord-006229-7yoilsho	6185	33	were	be	VBD
cord-006229-7yoilsho	6185	34	administered	administer	VBN
cord-006229-7yoilsho	6185	35	orally	orally	RB
cord-006229-7yoilsho	6185	36	for	for	IN
cord-006229-7yoilsho	6185	37	28	28	CD
cord-006229-7yoilsho	6185	38	days	day	NNS
cord-006229-7yoilsho	6185	39	to	to	IN
cord-006229-7yoilsho	6185	40	male	male	JJ
cord-006229-7yoilsho	6185	41	rats	rat	NNS
cord-006229-7yoilsho	6185	42	including	include	VBG
cord-006229-7yoilsho	6185	43	blood	blood	NN
cord-006229-7yoilsho	6185	44	sampling	sampling	NN
cord-006229-7yoilsho	6185	45	for	for	IN
cord-006229-7yoilsho	6185	46	metabolic	metabolic	JJ
cord-006229-7yoilsho	6185	47	profiling	profiling	NN
cord-006229-7yoilsho	6185	48	after	after	IN
cord-006229-7yoilsho	6185	49	7	7	CD
cord-006229-7yoilsho	6185	50	,	,	,
cord-006229-7yoilsho	6185	51	14	14	CD
cord-006229-7yoilsho	6185	52	and	and	CC
cord-006229-7yoilsho	6185	53	28	28	CD
cord-006229-7yoilsho	6185	54	days	day	NNS
cord-006229-7yoilsho	6185	55	.	.	.
cord-006229-7yoilsho	6186	1	Fluoroquinolones	fluoroquinolone	NNS
cord-006229-7yoilsho	6186	2	and	and	CC
cord-006229-7yoilsho	6186	3	tetracyclines	tetracycline	NNS
cord-006229-7yoilsho	6186	4	can	can	MD
cord-006229-7yoilsho	6186	5	be	be	VB
cord-006229-7yoilsho	6186	6	absorbed	absorb	VBN
cord-006229-7yoilsho	6186	7	from	from	IN
cord-006229-7yoilsho	6186	8	the	the	DT
cord-006229-7yoilsho	6186	9	gut	gut	NN
cord-006229-7yoilsho	6186	10	whereas	whereas	IN
cord-006229-7yoilsho	6186	11	aminoglycosides	aminoglycoside	NNS
cord-006229-7yoilsho	6186	12	can	can	MD
cord-006229-7yoilsho	6186	13	not	not	RB
cord-006229-7yoilsho	6186	14	.	.	.
cord-006229-7yoilsho	6187	1	To	to	TO
cord-006229-7yoilsho	6187	2	distinguish	distinguish	VB
cord-006229-7yoilsho	6187	3	between	between	IN
cord-006229-7yoilsho	6187	4	metabolite	metabolite	JJ
cord-006229-7yoilsho	6187	5	changes	change	NNS
cord-006229-7yoilsho	6187	6	caused	cause	VBN
cord-006229-7yoilsho	6187	7	by	by	IN
cord-006229-7yoilsho	6187	8	systemic	systemic	JJ
cord-006229-7yoilsho	6187	9	toxicity	toxicity	NN
cord-006229-7yoilsho	6187	10	of	of	IN
cord-006229-7yoilsho	6187	11	the	the	DT
cord-006229-7yoilsho	6187	12	antibiotics	antibiotic	NNS
cord-006229-7yoilsho	6187	13	and	and	CC
cord-006229-7yoilsho	6187	14	microbiome	microbiome	NN
cord-006229-7yoilsho	6187	15	related	relate	VBN
cord-006229-7yoilsho	6187	16	changes	change	NNS
cord-006229-7yoilsho	6187	17	,	,	,
cord-006229-7yoilsho	6187	18	the	the	DT
cord-006229-7yoilsho	6187	19	metabolites	metabolite	NNS
cord-006229-7yoilsho	6187	20	identified	identify	VBN
cord-006229-7yoilsho	6187	21	in	in	IN
cord-006229-7yoilsho	6187	22	the	the	DT
cord-006229-7yoilsho	6187	23	metabolome	metabolome	NN
cord-006229-7yoilsho	6187	24	pattern	pattern	NN
cord-006229-7yoilsho	6187	25	were	be	VBD
cord-006229-7yoilsho	6187	26	compared	compare	VBN
cord-006229-7yoilsho	6187	27	to	to	IN
cord-006229-7yoilsho	6187	28	a	a	DT
cord-006229-7yoilsho	6187	29	list	list	NN
cord-006229-7yoilsho	6187	30	of	of	IN
cord-006229-7yoilsho	6187	31	metabolites	metabolite	NNS
cord-006229-7yoilsho	6187	32	known	know	VBN
cord-006229-7yoilsho	6187	33	to	to	TO
cord-006229-7yoilsho	6187	34	be	be	VB
cord-006229-7yoilsho	6187	35	produced	produce	VBN
cord-006229-7yoilsho	6187	36	by	by	IN
cord-006229-7yoilsho	6187	37	the	the	DT
cord-006229-7yoilsho	6187	38	gastro	gastro	JJ
cord-006229-7yoilsho	6187	39	-	-	JJ
cord-006229-7yoilsho	6187	40	intestinal	intestinal	JJ
cord-006229-7yoilsho	6187	41	micro	micro	NNS
cord-006229-7yoilsho	6187	42	-	-	HYPH
cord-006229-7yoilsho	6187	43	organisms	organism	NNS
cord-006229-7yoilsho	6187	44	.	.	.
cord-006229-7yoilsho	6188	1	Beside	beside	IN
cord-006229-7yoilsho	6188	2	changes	change	NNS
cord-006229-7yoilsho	6188	3	mainly	mainly	RB
cord-006229-7yoilsho	6188	4	concerning	concern	VBG
cord-006229-7yoilsho	6188	5	amino	amino	JJ
cord-006229-7yoilsho	6188	6	acids	acid	NNS
cord-006229-7yoilsho	6188	7	and	and	CC
cord-006229-7yoilsho	6188	8	carbohydrates	carbohydrate	NNS
cord-006229-7yoilsho	6188	9	,	,	,
cord-006229-7yoilsho	6188	10	hippuric	hippuric	NN
cord-006229-7yoilsho	6188	11	acid	acid	NN
cord-006229-7yoilsho	6188	12	and	and	CC
cord-006229-7yoilsho	6188	13	indole-3-acetic	indole-3-acetic	JJ
cord-006229-7yoilsho	6188	14	acid	acid	NN
cord-006229-7yoilsho	6188	15	were	be	VBD
cord-006229-7yoilsho	6188	16	identified	identify	VBN
cord-006229-7yoilsho	6188	17	as	as	IN
cord-006229-7yoilsho	6188	18	key	key	JJ
cord-006229-7yoilsho	6188	19	metabolites	metabolite	NNS
cord-006229-7yoilsho	6188	20	being	be	VBG
cord-006229-7yoilsho	6188	21	affected	affect	VBN
cord-006229-7yoilsho	6188	22	by	by	IN
cord-006229-7yoilsho	6188	23	antibiotic	antibiotic	JJ
cord-006229-7yoilsho	6188	24	treatment	treatment	NN
cord-006229-7yoilsho	6188	25	.	.	.
cord-006229-7yoilsho	6189	1	For	for	IN
cord-006229-7yoilsho	6189	2	each	each	DT
cord-006229-7yoilsho	6189	3	class	class	NN
cord-006229-7yoilsho	6189	4	the	the	DT
cord-006229-7yoilsho	6189	5	following	follow	VBG
cord-006229-7yoilsho	6189	6	gut	gut	NN
cord-006229-7yoilsho	6189	7	metabolites	metabolite	NNS
cord-006229-7yoilsho	6189	8	were	be	VBD
cord-006229-7yoilsho	6189	9	found	find	VBN
cord-006229-7yoilsho	6189	10	to	to	TO
cord-006229-7yoilsho	6189	11	be	be	VB
cord-006229-7yoilsho	6189	12	unique	unique	JJ
cord-006229-7yoilsho	6189	13	:	:	:
cord-006229-7yoilsho	6189	14	indole-3-propionic	indole-3-propionic	JJ
cord-006229-7yoilsho	6189	15	acid	acid	NN
cord-006229-7yoilsho	6189	16	for	for	IN
cord-006229-7yoilsho	6189	17	aminoglycosides	aminoglycoside	NNS
cord-006229-7yoilsho	6189	18	,	,	,
cord-006229-7yoilsho	6189	19	taurine	taurine	NN
cord-006229-7yoilsho	6189	20	for	for	IN
cord-006229-7yoilsho	6189	21	fluoroquinolones	fluoroquinolone	NNS
cord-006229-7yoilsho	6189	22	,	,	,
cord-006229-7yoilsho	6190	1	3indoxylsulfate	3indoxylsulfate	LS
cord-006229-7yoilsho	6190	2	,	,	,
cord-006229-7yoilsho	6190	3	uracil	uracil	NN
cord-006229-7yoilsho	6190	4	and	and	CC
cord-006229-7yoilsho	6190	5	allantoin	allantoin	NN
cord-006229-7yoilsho	6190	6	for	for	IN
cord-006229-7yoilsho	6190	7	tetracyclines	tetracycline	NNS
cord-006229-7yoilsho	6190	8	.	.	.
cord-006229-7yoilsho	6191	1	For	for	IN
cord-006229-7yoilsho	6191	2	each	each	DT
cord-006229-7yoilsho	6191	3	class	class	NN
cord-006229-7yoilsho	6191	4	of	of	IN
cord-006229-7yoilsho	6191	5	antibiotics	antibiotic	NNS
cord-006229-7yoilsho	6192	1	specific	specific	JJ
cord-006229-7yoilsho	6192	2	and	and	CC
cord-006229-7yoilsho	6192	3	selective	selective	JJ
cord-006229-7yoilsho	6192	4	metabolome	metabolome	NN
cord-006229-7yoilsho	6192	5	patterns	pattern	NNS
cord-006229-7yoilsho	6192	6	could	could	MD
cord-006229-7yoilsho	6192	7	be	be	VB
cord-006229-7yoilsho	6192	8	established	establish	VBN
cord-006229-7yoilsho	6192	9	.	.	.
cord-006229-7yoilsho	6193	1	The	the	DT
cord-006229-7yoilsho	6193	2	results	result	NNS
cord-006229-7yoilsho	6193	3	suggest	suggest	VBP
cord-006229-7yoilsho	6193	4	that	that	IN
cord-006229-7yoilsho	6193	5	plasma	plasma	NN
cord-006229-7yoilsho	6193	6	based	base	VBN
cord-006229-7yoilsho	6193	7	metabolic	metabolic	JJ
cord-006229-7yoilsho	6193	8	profiling	profiling	NN
cord-006229-7yoilsho	6193	9	(	(	-LRB-
cord-006229-7yoilsho	6193	10	metabolomics	metabolomic	NNS
cord-006229-7yoilsho	6193	11	)	)	-RRB-
cord-006229-7yoilsho	6193	12	could	could	MD
cord-006229-7yoilsho	6193	13	be	be	VB
cord-006229-7yoilsho	6193	14	a	a	DT
cord-006229-7yoilsho	6193	15	suitable	suitable	JJ
cord-006229-7yoilsho	6193	16	tool	tool	NN
cord-006229-7yoilsho	6193	17	to	to	TO
cord-006229-7yoilsho	6193	18	investigate	investigate	VB
cord-006229-7yoilsho	6193	19	the	the	DT
cord-006229-7yoilsho	6193	20	effect	effect	NN
cord-006229-7yoilsho	6193	21	of	of	IN
cord-006229-7yoilsho	6193	22	antibiotics	antibiotic	NNS
cord-006229-7yoilsho	6193	23	on	on	IN
cord-006229-7yoilsho	6193	24	the	the	DT
cord-006229-7yoilsho	6193	25	functionality	functionality	NN
cord-006229-7yoilsho	6193	26	of	of	IN
cord-006229-7yoilsho	6193	27	the	the	DT
cord-006229-7yoilsho	6193	28	microbiome	microbiome	NN
cord-006229-7yoilsho	6193	29	and	and	CC
cord-006229-7yoilsho	6193	30	to	to	TO
cord-006229-7yoilsho	6193	31	obtain	obtain	VB
cord-006229-7yoilsho	6193	32	insight	insight	NN
cord-006229-7yoilsho	6193	33	in	in	IN
cord-006229-7yoilsho	6193	34	the	the	DT
cord-006229-7yoilsho	6193	35	mammalian	mammalian	JJ
cord-006229-7yoilsho	6193	36	-	-	HYPH
cord-006229-7yoilsho	6193	37	microbiome	microbiome	NN
cord-006229-7yoilsho	6193	38	co	co	NN
cord-006229-7yoilsho	6193	39	-	-	NN
cord-006229-7yoilsho	6193	40	metabolism	metabolism	NN
cord-006229-7yoilsho	6193	41	of	of	IN
cord-006229-7yoilsho	6193	42	endogenous	endogenous	JJ
cord-006229-7yoilsho	6193	43	metabolites	metabolite	NNS
cord-006229-7yoilsho	6193	44	.	.	.
cord-006229-7yoilsho	6194	1	Drug	drug	NN
cord-006229-7yoilsho	6194	2	-	-	HYPH
cord-006229-7yoilsho	6194	3	induced	induce	VBN
cord-006229-7yoilsho	6194	4	liver	liver	NN
cord-006229-7yoilsho	6194	5	injury	injury	NN
cord-006229-7yoilsho	6194	6	(	(	-LRB-
cord-006229-7yoilsho	6194	7	DILI	DILI	NNP
cord-006229-7yoilsho	6194	8	)	)	-RRB-
cord-006229-7yoilsho	6194	9	is	be	VBZ
cord-006229-7yoilsho	6194	10	still	still	RB
cord-006229-7yoilsho	6194	11	a	a	DT
cord-006229-7yoilsho	6194	12	major	major	JJ
cord-006229-7yoilsho	6194	13	reason	reason	NN
cord-006229-7yoilsho	6194	14	for	for	IN
cord-006229-7yoilsho	6194	15	termination	termination	NN
cord-006229-7yoilsho	6194	16	of	of	IN
cord-006229-7yoilsho	6194	17	clinical	clinical	JJ
cord-006229-7yoilsho	6194	18	trials	trial	NNS
cord-006229-7yoilsho	6194	19	and	and	CC
cord-006229-7yoilsho	6194	20	thus	thus	RB
cord-006229-7yoilsho	6194	21	is	be	VBZ
cord-006229-7yoilsho	6194	22	an	an	DT
cord-006229-7yoilsho	6194	23	important	important	JJ
cord-006229-7yoilsho	6194	24	concern	concern	NN
cord-006229-7yoilsho	6194	25	in	in	IN
cord-006229-7yoilsho	6194	26	drug	drug	NN
cord-006229-7yoilsho	6194	27	development	development	NN
cord-006229-7yoilsho	6194	28	.	.	.
cord-006229-7yoilsho	6195	1	Identification	identification	NN
cord-006229-7yoilsho	6195	2	and	and	CC
cord-006229-7yoilsho	6195	3	prediction	prediction	NN
cord-006229-7yoilsho	6195	4	of	of	IN
cord-006229-7yoilsho	6195	5	DILI	DILI	NNP
cord-006229-7yoilsho	6195	6	in	in	IN
cord-006229-7yoilsho	6195	7	the	the	DT
cord-006229-7yoilsho	6195	8	clinic	clinic	NN
cord-006229-7yoilsho	6195	9	and	and	CC
cord-006229-7yoilsho	6195	10	in	in	IN
cord-006229-7yoilsho	6195	11	preclinical	preclinical	JJ
cord-006229-7yoilsho	6195	12	safety	safety	NN
cord-006229-7yoilsho	6195	13	testing	testing	NN
cord-006229-7yoilsho	6195	14	still	still	RB
cord-006229-7yoilsho	6195	15	relies	rely	VBZ
cord-006229-7yoilsho	6195	16	on	on	IN
cord-006229-7yoilsho	6195	17	the	the	DT
cord-006229-7yoilsho	6195	18	classical	classical	JJ
cord-006229-7yoilsho	6195	19	clinical	clinical	JJ
cord-006229-7yoilsho	6195	20	chemistry	chemistry	NN
cord-006229-7yoilsho	6195	21	panel	panel	NN
cord-006229-7yoilsho	6195	22	and	and	CC
cord-006229-7yoilsho	6195	23	histopathology	histopathology	NN
cord-006229-7yoilsho	6195	24	with	with	IN
cord-006229-7yoilsho	6195	25	known	know	VBN
cord-006229-7yoilsho	6195	26	limitations	limitation	NNS
cord-006229-7yoilsho	6195	27	in	in	IN
cord-006229-7yoilsho	6195	28	sensitivity	sensitivity	NN
cord-006229-7yoilsho	6195	29	and	and	CC
cord-006229-7yoilsho	6195	30	specificity	specificity	NN
cord-006229-7yoilsho	6195	31	.	.	.
cord-006229-7yoilsho	6196	1	In	in	IN
cord-006229-7yoilsho	6196	2	the	the	DT
cord-006229-7yoilsho	6196	3	last	last	JJ
cord-006229-7yoilsho	6196	4	years	year	NNS
cord-006229-7yoilsho	6196	5	bile	bile	NN
cord-006229-7yoilsho	6196	6	acids	acid	NNS
cord-006229-7yoilsho	6196	7	(	(	-LRB-
cord-006229-7yoilsho	6196	8	BAs	BAs	NNP
cord-006229-7yoilsho	6196	9	)	)	-RRB-
cord-006229-7yoilsho	6196	10	have	have	VBP
cord-006229-7yoilsho	6196	11	been	be	VBN
cord-006229-7yoilsho	6196	12	studied	study	VBN
cord-006229-7yoilsho	6196	13	as	as	IN
cord-006229-7yoilsho	6196	14	potential	potential	JJ
cord-006229-7yoilsho	6196	15	biomarkers	biomarker	NNS
cord-006229-7yoilsho	6196	16	to	to	TO
cord-006229-7yoilsho	6196	17	better	better	RB
cord-006229-7yoilsho	6196	18	characterize	characterize	VB
cord-006229-7yoilsho	6196	19	drug	drug	NN
cord-006229-7yoilsho	6196	20	-	-	HYPH
cord-006229-7yoilsho	6196	21	induced	induce	VBN
cord-006229-7yoilsho	6196	22	liver	liver	NN
cord-006229-7yoilsho	6196	23	injury	injury	NN
cord-006229-7yoilsho	6196	24	with	with	IN
cord-006229-7yoilsho	6196	25	promising	promising	JJ
cord-006229-7yoilsho	6196	26	results	result	NNS
cord-006229-7yoilsho	6197	1	(	(	-LRB-
cord-006229-7yoilsho	6197	2	Ellinger	Ellinger	NNP
cord-006229-7yoilsho	6197	3	-	-	HYPH
cord-006229-7yoilsho	6197	4	Ziegelbauer	Ziegelbauer	NNP
cord-006229-7yoilsho	6197	5	et	et	FW
cord-006229-7yoilsho	6197	6	al	al	NNP
cord-006229-7yoilsho	6197	7	.	.	NNP
cord-006229-7yoilsho	6197	8	,	,	,
cord-006229-7yoilsho	6197	9	2011	2011	CD
cord-006229-7yoilsho	6197	10	;	;	:
cord-006229-7yoilsho	6197	11	Luo	Luo	NNP
cord-006229-7yoilsho	6197	12	,	,	,
cord-006229-7yoilsho	6197	13	Schomaker	Schomaker	NNP
cord-006229-7yoilsho	6197	14	,	,	,
cord-006229-7yoilsho	6197	15	Houle	Houle	NNP
cord-006229-7yoilsho	6197	16	,	,	,
cord-006229-7yoilsho	6197	17	Aubrecht	Aubrecht	NNP
cord-006229-7yoilsho	6197	18	,	,	,
cord-006229-7yoilsho	6197	19	&	&	CC
cord-006229-7yoilsho	6197	20	Colangelo	Colangelo	NNP
cord-006229-7yoilsho	6197	21	,	,	,
cord-006229-7yoilsho	6197	22	2014	2014	CD
cord-006229-7yoilsho	6197	23	;	;	:
cord-006229-7yoilsho	6197	24	Yamazaki	Yamazaki	NNP
cord-006229-7yoilsho	6197	25	et	et	NNP
cord-006229-7yoilsho	6197	26	al	al	NNP
cord-006229-7yoilsho	6197	27	.	.	NNP
cord-006229-7yoilsho	6197	28	,	,	,
cord-006229-7yoilsho	6197	29	2013	2013	CD
cord-006229-7yoilsho	6197	30	)	)	-RRB-
cord-006229-7yoilsho	6197	31	.	.	.
cord-006229-7yoilsho	6198	1	To	to	TO
cord-006229-7yoilsho	6198	2	evaluate	evaluate	VB
cord-006229-7yoilsho	6198	3	whether	whether	IN
cord-006229-7yoilsho	6198	4	a	a	DT
cord-006229-7yoilsho	6198	5	targeted	target	VBN
cord-006229-7yoilsho	6198	6	bile	bile	NN
cord-006229-7yoilsho	6198	7	acid	acid	NN
cord-006229-7yoilsho	6198	8	profiling	profiling	NN
cord-006229-7yoilsho	6198	9	via	via	IN
cord-006229-7yoilsho	6198	10	LC	LC	NNP
cord-006229-7yoilsho	6198	11	-	-	HYPH
cord-006229-7yoilsho	6198	12	MS	MS	NNP
cord-006229-7yoilsho	6198	13	/	/	SYM
cord-006229-7yoilsho	6198	14	MS	MS	NNP
cord-006229-7yoilsho	6198	15	in	in	IN
cord-006229-7yoilsho	6198	16	plasma	plasma	NN
cord-006229-7yoilsho	6198	17	and	and	CC
cord-006229-7yoilsho	6198	18	liver	liver	NN
cord-006229-7yoilsho	6198	19	tissue	tissue	NN
cord-006229-7yoilsho	6198	20	can	can	MD
cord-006229-7yoilsho	6198	21	improve	improve	VB
cord-006229-7yoilsho	6198	22	assessment	assessment	NN
cord-006229-7yoilsho	6198	23	of	of	IN
cord-006229-7yoilsho	6198	24	liver	liver	NN
cord-006229-7yoilsho	6198	25	injury	injury	NN
cord-006229-7yoilsho	6198	26	,	,	,
cord-006229-7yoilsho	6198	27	methapyrilene	methapyrilene	NNP
cord-006229-7yoilsho	6198	28	(	(	-LRB-
cord-006229-7yoilsho	6198	29	MPy	MPy	NNP
cord-006229-7yoilsho	6198	30	)	)	-RRB-
cord-006229-7yoilsho	6198	31	a	a	DT
cord-006229-7yoilsho	6198	32	known	know	VBN
cord-006229-7yoilsho	6198	33	hepatotoxin	hepatotoxin	NN
cord-006229-7yoilsho	6198	34	,	,	,
cord-006229-7yoilsho	6198	35	or	or	CC
cord-006229-7yoilsho	6198	36	corresponding	corresponding	JJ
cord-006229-7yoilsho	6198	37	vehicle	vehicle	NN
cord-006229-7yoilsho	6198	38	,	,	,
cord-006229-7yoilsho	6198	39	was	be	VBD
cord-006229-7yoilsho	6198	40	administered	administer	VBN
cord-006229-7yoilsho	6198	41	daily	daily	RB
cord-006229-7yoilsho	6198	42	to	to	IN
cord-006229-7yoilsho	6198	43	male	male	JJ
cord-006229-7yoilsho	6198	44	Wistar	Wistar	NNP
cord-006229-7yoilsho	6198	45	rats	rat	NNS
cord-006229-7yoilsho	6198	46	at	at	IN
cord-006229-7yoilsho	6198	47	a	a	DT
cord-006229-7yoilsho	6198	48	low	low	JJ
cord-006229-7yoilsho	6198	49	(	(	-LRB-
cord-006229-7yoilsho	6198	50	30	30	CD
cord-006229-7yoilsho	6198	51	mg	mg	NN
cord-006229-7yoilsho	6198	52	/	/	SYM
cord-006229-7yoilsho	6198	53	kg	kg	NNP
cord-006229-7yoilsho	6198	54	)	)	-RRB-
cord-006229-7yoilsho	6198	55	and	and	CC
cord-006229-7yoilsho	6198	56	a	a	DT
cord-006229-7yoilsho	6198	57	high	high	JJ
cord-006229-7yoilsho	6198	58	(	(	-LRB-
cord-006229-7yoilsho	6198	59	80	80	CD
cord-006229-7yoilsho	6198	60	mg	mg	NNP
cord-006229-7yoilsho	6198	61	/	/	SYM
cord-006229-7yoilsho	6198	62	kg	kg	NNP
cord-006229-7yoilsho	6198	63	)	)	-RRB-
cord-006229-7yoilsho	6198	64	dose	dose	NN
cord-006229-7yoilsho	6198	65	.	.	.
cord-006229-7yoilsho	6199	1	Rats	rat	NNS
cord-006229-7yoilsho	6199	2	were	be	VBD
cord-006229-7yoilsho	6199	3	sacrificed	sacrifice	VBN
cord-006229-7yoilsho	6199	4	following	follow	VBG
cord-006229-7yoilsho	6199	5	3	3	CD
cord-006229-7yoilsho	6199	6	,	,	,
cord-006229-7yoilsho	6199	7	7	7	CD
cord-006229-7yoilsho	6199	8	,	,	,
cord-006229-7yoilsho	6199	9	or	or	CC
cord-006229-7yoilsho	6199	10	14	14	CD
cord-006229-7yoilsho	6199	11	consecutive	consecutive	JJ
cord-006229-7yoilsho	6199	12	daily	daily	JJ
cord-006229-7yoilsho	6199	13	doses	dose	NNS
cord-006229-7yoilsho	6199	14	,	,	,
cord-006229-7yoilsho	6199	15	or	or	CC
cord-006229-7yoilsho	6199	16	after	after	IN
cord-006229-7yoilsho	6199	17	recovery	recovery	NN
cord-006229-7yoilsho	6199	18	10	10	CD
cord-006229-7yoilsho	6199	19	days	day	NNS
cord-006229-7yoilsho	6199	20	following	follow	VBG
cord-006229-7yoilsho	6199	21	14	14	CD
cord-006229-7yoilsho	6199	22	consecutive	consecutive	JJ
cord-006229-7yoilsho	6199	23	administrations	administration	NNS
cord-006229-7yoilsho	6199	24	of	of	IN
cord-006229-7yoilsho	6199	25	MPy	MPy	NNS
cord-006229-7yoilsho	6199	26	or	or	CC
cord-006229-7yoilsho	6199	27	vehicle	vehicle	NN
cord-006229-7yoilsho	6199	28	.	.	.
cord-006229-7yoilsho	6200	1	In	in	IN
cord-006229-7yoilsho	6200	2	addition	addition	NN
cord-006229-7yoilsho	6200	3	to	to	IN
cord-006229-7yoilsho	6200	4	bile	bile	NN
cord-006229-7yoilsho	6200	5	acids	acid	NNS
cord-006229-7yoilsho	6200	6	which	which	WDT
cord-006229-7yoilsho	6200	7	were	be	VBD
cord-006229-7yoilsho	6200	8	determined	determine	VBN
cord-006229-7yoilsho	6200	9	both	both	CC
cord-006229-7yoilsho	6200	10	in	in	IN
cord-006229-7yoilsho	6200	11	plasma	plasma	NN
cord-006229-7yoilsho	6200	12	and	and	CC
cord-006229-7yoilsho	6200	13	tissue	tissue	NN
cord-006229-7yoilsho	6200	14	,	,	,
cord-006229-7yoilsho	6200	15	conventional	conventional	JJ
cord-006229-7yoilsho	6200	16	preclinical	preclinical	JJ
cord-006229-7yoilsho	6200	17	safety	safety	NN
cord-006229-7yoilsho	6200	18	endpoints	endpoint	NNS
cord-006229-7yoilsho	6200	19	(	(	-LRB-
cord-006229-7yoilsho	6201	1	Histopathology	Histopathology	NNP
cord-006229-7yoilsho	6201	2	and	and	CC
cord-006229-7yoilsho	6201	3	Clinical	Clinical	NNP
cord-006229-7yoilsho	6201	4	Chemistry	Chemistry	NNP
cord-006229-7yoilsho	6201	5	)	)	-RRB-
cord-006229-7yoilsho	6201	6	assessment	assessment	NN
cord-006229-7yoilsho	6201	7	and	and	CC
cord-006229-7yoilsho	6201	8	gene	gene	NN
cord-006229-7yoilsho	6201	9	expression	expression	NN
cord-006229-7yoilsho	6201	10	profiling	profiling	NN
cord-006229-7yoilsho	6201	11	was	be	VBD
cord-006229-7yoilsho	6201	12	performed	perform	VBN
cord-006229-7yoilsho	6201	13	in	in	IN
cord-006229-7yoilsho	6201	14	liver	liver	NN
cord-006229-7yoilsho	6201	15	to	to	TO
cord-006229-7yoilsho	6201	16	obtain	obtain	VB
cord-006229-7yoilsho	6201	17	mechanistic	mechanistic	JJ
cord-006229-7yoilsho	6201	18	information	information	NN
cord-006229-7yoilsho	6201	19	about	about	IN
cord-006229-7yoilsho	6201	20	potential	potential	JJ
cord-006229-7yoilsho	6201	21	changes	change	NNS
cord-006229-7yoilsho	6201	22	in	in	IN
cord-006229-7yoilsho	6201	23	regulation	regulation	NN
cord-006229-7yoilsho	6201	24	of	of	IN
cord-006229-7yoilsho	6201	25	bile	bile	NN
cord-006229-7yoilsho	6201	26	acid	acid	NN
cord-006229-7yoilsho	6201	27	levels	level	NNS
cord-006229-7yoilsho	6201	28	.	.	.
cord-006229-7yoilsho	6202	1	Conventional	conventional	JJ
cord-006229-7yoilsho	6202	2	findings	finding	NNS
cord-006229-7yoilsho	6202	3	included	include	VBD
cord-006229-7yoilsho	6202	4	periportal	periportal	JJ
cord-006229-7yoilsho	6202	5	necrosis	necrosis	NN
cord-006229-7yoilsho	6202	6	,	,	,
cord-006229-7yoilsho	6202	7	inflammation	inflammation	NN
cord-006229-7yoilsho	6202	8	and	and	CC
cord-006229-7yoilsho	6202	9	biliary	biliary	JJ
cord-006229-7yoilsho	6202	10	hyperplasia	hyperplasia	NN
cord-006229-7yoilsho	6202	11	,	,	,
cord-006229-7yoilsho	6202	12	and	and	CC
cord-006229-7yoilsho	6202	13	increased	increase	VBN
cord-006229-7yoilsho	6202	14	liver	liver	NN
cord-006229-7yoilsho	6202	15	enzyme	enzyme	NN
cord-006229-7yoilsho	6202	16	activity	activity	NN
cord-006229-7yoilsho	6202	17	and	and	CC
cord-006229-7yoilsho	6202	18	bilirubin	bilirubin	NN
cord-006229-7yoilsho	6202	19	levels	level	NNS
cord-006229-7yoilsho	6202	20	during	during	IN
cord-006229-7yoilsho	6202	21	the	the	DT
cord-006229-7yoilsho	6202	22	treatment	treatment	NN
cord-006229-7yoilsho	6202	23	phase	phase	NN
cord-006229-7yoilsho	6202	24	.	.	.
cord-006229-7yoilsho	6203	1	The	the	DT
cord-006229-7yoilsho	6203	2	bile	bile	NN
cord-006229-7yoilsho	6203	3	acid	acid	NN
cord-006229-7yoilsho	6203	4	pattern	pattern	NN
cord-006229-7yoilsho	6203	5	showed	show	VBD
cord-006229-7yoilsho	6203	6	increased	increase	VBN
cord-006229-7yoilsho	6203	7	levels	level	NNS
cord-006229-7yoilsho	6203	8	of	of	IN
cord-006229-7yoilsho	6203	9	conjugated	conjugated	JJ
cord-006229-7yoilsho	6203	10	and	and	CC
cord-006229-7yoilsho	6203	11	unconjugated	unconjugated	JJ
cord-006229-7yoilsho	6203	12	bile	bile	NN
cord-006229-7yoilsho	6203	13	acids	acid	NNS
cord-006229-7yoilsho	6203	14	in	in	IN
cord-006229-7yoilsho	6203	15	low	low	JJ
cord-006229-7yoilsho	6203	16	dose	dose	NN
cord-006229-7yoilsho	6203	17	and	and	CC
cord-006229-7yoilsho	6203	18	high	high	JJ
cord-006229-7yoilsho	6203	19	dose	dose	NN
cord-006229-7yoilsho	6203	20	groups	group	NNS
cord-006229-7yoilsho	6203	21	compared	compare	VBN
cord-006229-7yoilsho	6203	22	to	to	IN
cord-006229-7yoilsho	6203	23	the	the	DT
cord-006229-7yoilsho	6203	24	controls	control	NNS
cord-006229-7yoilsho	6203	25	after	after	IN
cord-006229-7yoilsho	6203	26	administration	administration	NN
cord-006229-7yoilsho	6203	27	of	of	IN
cord-006229-7yoilsho	6203	28	methapyrilene	methapyrilene	NNP
cord-006229-7yoilsho	6203	29	.	.	.
cord-006229-7yoilsho	6204	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	6204	2	,	,	,
cord-006229-7yoilsho	6204	3	although	although	IN
cord-006229-7yoilsho	6204	4	liver	liver	NN
cord-006229-7yoilsho	6204	5	enzyme	enzyme	NN
cord-006229-7yoilsho	6204	6	activity	activity	NN
cord-006229-7yoilsho	6204	7	and	and	CC
cord-006229-7yoilsho	6204	8	bilirubin	bilirubin	NN
cord-006229-7yoilsho	6204	9	levels	level	NNS
cord-006229-7yoilsho	6204	10	in	in	IN
cord-006229-7yoilsho	6204	11	serum	serum	NN
cord-006229-7yoilsho	6204	12	were	be	VBD
cord-006229-7yoilsho	6204	13	decreased	decrease	VBN
cord-006229-7yoilsho	6204	14	again	again	RB
cord-006229-7yoilsho	6204	15	in	in	IN
cord-006229-7yoilsho	6204	16	the	the	DT
cord-006229-7yoilsho	6204	17	recovery	recovery	NN
cord-006229-7yoilsho	6204	18	groups	group	NNS
cord-006229-7yoilsho	6204	19	,	,	,
cord-006229-7yoilsho	6204	20	suggesting	suggest	VBG
cord-006229-7yoilsho	6204	21	recovering	recover	VBG
cord-006229-7yoilsho	6204	22	liver	liver	NN
cord-006229-7yoilsho	6204	23	injury	injury	NN
cord-006229-7yoilsho	6204	24	,	,	,
cord-006229-7yoilsho	6204	25	bile	bile	NN
cord-006229-7yoilsho	6204	26	acid	acid	NN
cord-006229-7yoilsho	6204	27	concentrations	concentration	NNS
cord-006229-7yoilsho	6204	28	remained	remain	VBD
cord-006229-7yoilsho	6204	29	elevated	elevated	JJ
cord-006229-7yoilsho	6204	30	with	with	IN
cord-006229-7yoilsho	6204	31	no	no	DT
cord-006229-7yoilsho	6204	32	signs	sign	NNS
cord-006229-7yoilsho	6204	33	of	of	IN
cord-006229-7yoilsho	6204	34	recovery	recovery	NN
cord-006229-7yoilsho	6204	35	.	.	.
cord-006229-7yoilsho	6205	1	Analysis	Analysis	NNP
cord-006229-7yoilsho	6205	2	of	of	IN
cord-006229-7yoilsho	6205	3	transcriptomics	transcriptomics	NNP
cord-006229-7yoilsho	6205	4	data	datum	NNS
cord-006229-7yoilsho	6205	5	revealed	reveal	VBD
cord-006229-7yoilsho	6205	6	decreased	decrease	VBN
cord-006229-7yoilsho	6205	7	levels	level	NNS
cord-006229-7yoilsho	6205	8	of	of	IN
cord-006229-7yoilsho	6205	9	mRNA	mrna	NN
cord-006229-7yoilsho	6205	10	encoding	encoding	NN
cord-006229-7yoilsho	6205	11	α	α	NNP
cord-006229-7yoilsho	6205	12	-	-	HYPH
cord-006229-7yoilsho	6205	13	Methylacyl	Methylacyl	NNP
cord-006229-7yoilsho	6205	14	-	-	HYPH
cord-006229-7yoilsho	6205	15	CoA	CoA	NNP
cord-006229-7yoilsho	6205	16	racemase	racemase	NN
cord-006229-7yoilsho	6205	17	(	(	-LRB-
cord-006229-7yoilsho	6205	18	AMACR	AMACR	NNP
cord-006229-7yoilsho	6205	19	)	)	-RRB-
cord-006229-7yoilsho	6205	20	4	4	CD
cord-006229-7yoilsho	6205	21	and	and	CC
cord-006229-7yoilsho	6205	22	15	15	CD
cord-006229-7yoilsho	6205	23	days	day	NNS
cord-006229-7yoilsho	6205	24	after	after	IN
cord-006229-7yoilsho	6205	25	dosing	dosing	NN
cord-006229-7yoilsho	6205	26	,	,	,
cord-006229-7yoilsho	6205	27	a	a	DT
cord-006229-7yoilsho	6205	28	gene	gene	NN
cord-006229-7yoilsho	6205	29	responsible	responsible	JJ
cord-006229-7yoilsho	6205	30	for	for	IN
cord-006229-7yoilsho	6205	31	bile	bile	NN
cord-006229-7yoilsho	6205	32	acid	acid	NN
cord-006229-7yoilsho	6205	33	synthesis	synthesis	NN
cord-006229-7yoilsho	6205	34	.	.	.
cord-006229-7yoilsho	6206	1	Membrane	membrane	NN
cord-006229-7yoilsho	6206	2	transport	transport	NN
cord-006229-7yoilsho	6206	3	systems	system	NNS
cord-006229-7yoilsho	6206	4	for	for	IN
cord-006229-7yoilsho	6206	5	bile	bile	NN
cord-006229-7yoilsho	6206	6	acids	acid	NNS
cord-006229-7yoilsho	6206	7	like	like	IN
cord-006229-7yoilsho	6206	8	sodium	sodium	NN
cord-006229-7yoilsho	6207	1	/taurocholate	/taurocholate	.
cord-006229-7yoilsho	6208	1	co	co	VB
cord-006229-7yoilsho	6208	2	-	-	JJ
cord-006229-7yoilsho	6208	3	transporting	transporting	JJ
cord-006229-7yoilsho	6208	4	polypeptide	polypeptide	NN
cord-006229-7yoilsho	6208	5	(	(	-LRB-
cord-006229-7yoilsho	6208	6	NTCP	NTCP	NNP
cord-006229-7yoilsho	6208	7	)	)	-RRB-
cord-006229-7yoilsho	6208	8	and	and	CC
cord-006229-7yoilsho	6208	9	Organic	organic	JJ
cord-006229-7yoilsho	6208	10	anion	anion	NN
cord-006229-7yoilsho	6208	11	transporting	transport	VBG
cord-006229-7yoilsho	6208	12	polypeptide	polypeptide	NN
cord-006229-7yoilsho	6208	13	1	1	CD
cord-006229-7yoilsho	6209	1	(	(	-LRB-
cord-006229-7yoilsho	6209	2	OATP1	OATP1	NNP
cord-006229-7yoilsho	6209	3	)	)	-RRB-
cord-006229-7yoilsho	6209	4	expression	expression	NN
cord-006229-7yoilsho	6209	5	were	be	VBD
cord-006229-7yoilsho	6209	6	down	down	RB
cord-006229-7yoilsho	6209	7	regulated	regulate	VBN
cord-006229-7yoilsho	6209	8	as	as	RB
cord-006229-7yoilsho	6209	9	well	well	RB
cord-006229-7yoilsho	6209	10	,	,	,
cord-006229-7yoilsho	6209	11	indicating	indicate	VBG
cord-006229-7yoilsho	6209	12	that	that	IN
cord-006229-7yoilsho	6209	13	the	the	DT
cord-006229-7yoilsho	6209	14	increased	increase	VBN
cord-006229-7yoilsho	6209	15	bile	bile	NN
cord-006229-7yoilsho	6209	16	acid	acid	NN
cord-006229-7yoilsho	6209	17	concentrations	concentration	NNS
cord-006229-7yoilsho	6209	18	in	in	IN
cord-006229-7yoilsho	6209	19	plasma	plasma	NN
cord-006229-7yoilsho	6209	20	and	and	CC
cord-006229-7yoilsho	6209	21	tissue	tissue	NN
cord-006229-7yoilsho	6209	22	could	could	MD
cord-006229-7yoilsho	6209	23	be	be	VB
cord-006229-7yoilsho	6209	24	attributable	attributable	JJ
cord-006229-7yoilsho	6209	25	to	to	IN
cord-006229-7yoilsho	6209	26	reduced	reduce	VBN
cord-006229-7yoilsho	6209	27	uptake	uptake	NN
cord-006229-7yoilsho	6209	28	by	by	IN
cord-006229-7yoilsho	6209	29	the	the	DT
cord-006229-7yoilsho	6209	30	hepatocyte	hepatocyte	NN
cord-006229-7yoilsho	6209	31	.	.	.
cord-006229-7yoilsho	6210	1	In	in	IN
cord-006229-7yoilsho	6210	2	summary	summary	NN
cord-006229-7yoilsho	6210	3	the	the	DT
cord-006229-7yoilsho	6210	4	data	datum	NNS
cord-006229-7yoilsho	6210	5	suggest	suggest	VBP
cord-006229-7yoilsho	6210	6	that	that	IN
cord-006229-7yoilsho	6210	7	targeted	target	VBN
cord-006229-7yoilsho	6210	8	bile	bile	NN
cord-006229-7yoilsho	6210	9	acid	acid	NN
cord-006229-7yoilsho	6210	10	profiling	profiling	NN
cord-006229-7yoilsho	6210	11	could	could	MD
cord-006229-7yoilsho	6210	12	be	be	VB
cord-006229-7yoilsho	6210	13	used	use	VBN
cord-006229-7yoilsho	6210	14	as	as	IN
cord-006229-7yoilsho	6210	15	potential	potential	JJ
cord-006229-7yoilsho	6210	16	biomarkers	biomarker	NNS
cord-006229-7yoilsho	6210	17	to	to	TO
cord-006229-7yoilsho	6210	18	enhance	enhance	VB
cord-006229-7yoilsho	6210	19	assessment	assessment	NN
cord-006229-7yoilsho	6210	20	of	of	IN
cord-006229-7yoilsho	6210	21	drug	drug	NN
cord-006229-7yoilsho	6210	22	-	-	HYPH
cord-006229-7yoilsho	6210	23	induced	induce	VBN
cord-006229-7yoilsho	6210	24	liver	liver	NN
cord-006229-7yoilsho	6210	25	injury	injury	NN
cord-006229-7yoilsho	6210	26	.	.	.
cord-006229-7yoilsho	6211	1	Photorhabdus	Photorhabdus	NNP
cord-006229-7yoilsho	6211	2	asymbiotica	asymbiotica	NNP
cord-006229-7yoilsho	6211	3	is	be	VBZ
cord-006229-7yoilsho	6211	4	an	an	DT
cord-006229-7yoilsho	6211	5	entomopathogen	entomopathogen	NN
cord-006229-7yoilsho	6211	6	and	and	CC
cord-006229-7yoilsho	6211	7	emerging	emerge	VBG
cord-006229-7yoilsho	6211	8	human	human	JJ
cord-006229-7yoilsho	6211	9	pathogen	pathogen	NN
cord-006229-7yoilsho	6211	10	causing	cause	VBG
cord-006229-7yoilsho	6211	11	soft	soft	JJ
cord-006229-7yoilsho	6211	12	tissue	tissue	NN
cord-006229-7yoilsho	6211	13	infections	infection	NNS
cord-006229-7yoilsho	6211	14	in	in	IN
cord-006229-7yoilsho	6211	15	humans	human	NNS
cord-006229-7yoilsho	6211	16	.	.	.
cord-006229-7yoilsho	6212	1	Photorhabdus	Photorhabdus	NNP
cord-006229-7yoilsho	6212	2	asymbiotica	asymbiotica	NNP
cord-006229-7yoilsho	6212	3	produces	produce	VBZ
cord-006229-7yoilsho	6212	4	the	the	DT
cord-006229-7yoilsho	6212	5	bacterial	bacterial	JJ
cord-006229-7yoilsho	6212	6	protein	protein	NN
cord-006229-7yoilsho	6212	7	toxin	toxin	NN
cord-006229-7yoilsho	6212	8	PaTox	PaTox	NNP
cord-006229-7yoilsho	6212	9	,	,	,
cord-006229-7yoilsho	6212	10	which	which	WDT
cord-006229-7yoilsho	6212	11	is	be	VBZ
cord-006229-7yoilsho	6212	12	cytotoxic	cytotoxic	JJ
cord-006229-7yoilsho	6212	13	for	for	IN
cord-006229-7yoilsho	6212	14	various	various	JJ
cord-006229-7yoilsho	6212	15	cell	cell	NN
cord-006229-7yoilsho	6212	16	lines	line	NNS
cord-006229-7yoilsho	6212	17	and	and	CC
cord-006229-7yoilsho	6212	18	kills	kill	VBZ
cord-006229-7yoilsho	6212	19	insect	insect	NN
cord-006229-7yoilsho	6212	20	larvae	larva	NNS
cord-006229-7yoilsho	6212	21	.	.	.
cord-006229-7yoilsho	6213	1	Previous	previous	JJ
cord-006229-7yoilsho	6213	2	studies	study	NNS
cord-006229-7yoilsho	6213	3	have	have	VBP
cord-006229-7yoilsho	6213	4	established	establish	VBN
cord-006229-7yoilsho	6213	5	that	that	IN
cord-006229-7yoilsho	6213	6	PaTox	PaTox	NNP
cord-006229-7yoilsho	6213	7	harbors	harbor	VBZ
cord-006229-7yoilsho	6213	8	two	two	CD
cord-006229-7yoilsho	6213	9	enzymatic	enzymatic	JJ
cord-006229-7yoilsho	6213	10	active	active	JJ
cord-006229-7yoilsho	6213	11	domains	domain	NNS
cord-006229-7yoilsho	6213	12	,	,	,
cord-006229-7yoilsho	6213	13	a	a	DT
cord-006229-7yoilsho	6213	14	glycosyltransferase	glycosyltransferase	NN
cord-006229-7yoilsho	6213	15	and	and	CC
cord-006229-7yoilsho	6213	16	a	a	DT
cord-006229-7yoilsho	6213	17	deamidase	deamidase	NN
cord-006229-7yoilsho	6213	18	domain	domain	NN
cord-006229-7yoilsho	6213	19	.	.	.
cord-006229-7yoilsho	6214	1	The	the	DT
cord-006229-7yoilsho	6214	2	glycosyltransferase	glycosyltransferase	NN
cord-006229-7yoilsho	6214	3	domain	domain	NN
cord-006229-7yoilsho	6214	4	inactivates	inactivate	VBZ
cord-006229-7yoilsho	6214	5	host	host	NN
cord-006229-7yoilsho	6214	6	GTPases	gtpase	NNS
cord-006229-7yoilsho	6214	7	of	of	IN
cord-006229-7yoilsho	6214	8	the	the	DT
cord-006229-7yoilsho	6214	9	Rho	Rho	NNP
cord-006229-7yoilsho	6214	10	family	family	NN
cord-006229-7yoilsho	6214	11	by	by	IN
cord-006229-7yoilsho	6214	12	GlcNAcylation	glcnacylation	NN
cord-006229-7yoilsho	6214	13	of	of	IN
cord-006229-7yoilsho	6214	14	a	a	DT
cord-006229-7yoilsho	6214	15	tyrosine	tyrosine	NN
cord-006229-7yoilsho	6214	16	residue	residue	NN
cord-006229-7yoilsho	6214	17	in	in	IN
cord-006229-7yoilsho	6214	18	the	the	DT
cord-006229-7yoilsho	6214	19	effector	effector	NN
cord-006229-7yoilsho	6214	20	binding	bind	VBG
cord-006229-7yoilsho	6214	21	loop	loop	NN
cord-006229-7yoilsho	6214	22	,	,	,
cord-006229-7yoilsho	6214	23	which	which	WDT
cord-006229-7yoilsho	6214	24	results	result	VBZ
cord-006229-7yoilsho	6214	25	in	in	IN
cord-006229-7yoilsho	6214	26	the	the	DT
cord-006229-7yoilsho	6214	27	disassembly	disassembly	NN
cord-006229-7yoilsho	6214	28	of	of	IN
cord-006229-7yoilsho	6214	29	the	the	DT
cord-006229-7yoilsho	6214	30	actin	actin	NN
cord-006229-7yoilsho	6214	31	cytoskeleton	cytoskeleton	NN
cord-006229-7yoilsho	6214	32	.	.	.
cord-006229-7yoilsho	6215	1	The	the	DT
cord-006229-7yoilsho	6215	2	deamidase	deamidase	NN
cord-006229-7yoilsho	6215	3	domain	domain	NN
cord-006229-7yoilsho	6215	4	deamidates	deamidate	VBZ
cord-006229-7yoilsho	6215	5	a	a	DT
cord-006229-7yoilsho	6215	6	crucial	crucial	JJ
cord-006229-7yoilsho	6215	7	glutamine	glutamine	NN
cord-006229-7yoilsho	6215	8	residue	residue	NN
cord-006229-7yoilsho	6215	9	in	in	IN
cord-006229-7yoilsho	6215	10	heterotrimeric	heterotrimeric	NN
cord-006229-7yoilsho	6215	11	Gα	Gα	NNP
cord-006229-7yoilsho	6215	12	i	i	PRP
cord-006229-7yoilsho	6215	13	and	and	CC
cord-006229-7yoilsho	6215	14	Gα	Gα	NNP
cord-006229-7yoilsho	6215	15	q/11	q/11	NNS
cord-006229-7yoilsho	6215	16	proteins	protein	NNS
cord-006229-7yoilsho	6215	17	,	,	,
cord-006229-7yoilsho	6215	18	which	which	WDT
cord-006229-7yoilsho	6215	19	renders	render	VBZ
cord-006229-7yoilsho	6215	20	the	the	DT
cord-006229-7yoilsho	6215	21	G	g	NN
cord-006229-7yoilsho	6215	22	proteins	protein	NNS
cord-006229-7yoilsho	6215	23	constitutive	constitutive	JJ
cord-006229-7yoilsho	6215	24	active	active	JJ
cord-006229-7yoilsho	6215	25	.	.	.
cord-006229-7yoilsho	6216	1	Sequence	sequence	NN
cord-006229-7yoilsho	6216	2	and	and	CC
cord-006229-7yoilsho	6216	3	structural	structural	JJ
cord-006229-7yoilsho	6216	4	homology	homology	NN
cord-006229-7yoilsho	6216	5	analyses	analysis	NNS
cord-006229-7yoilsho	6216	6	of	of	IN
cord-006229-7yoilsho	6216	7	PaTox	PaTox	NNP
cord-006229-7yoilsho	6216	8	revealed	reveal	VBD
cord-006229-7yoilsho	6216	9	a	a	DT
cord-006229-7yoilsho	6216	10	third	third	JJ
cord-006229-7yoilsho	6216	11	domain	domain	NN
cord-006229-7yoilsho	6216	12	(	(	-LRB-
cord-006229-7yoilsho	6216	13	PaTox	PaTox	NNP
cord-006229-7yoilsho	6216	14	P	P	NNP
cord-006229-7yoilsho	6216	15	)	)	-RRB-
cord-006229-7yoilsho	6216	16	resembling	resemble	VBG
cord-006229-7yoilsho	6216	17	peptidases	peptidase	NNS
cord-006229-7yoilsho	6216	18	of	of	IN
cord-006229-7yoilsho	6216	19	the	the	DT
cord-006229-7yoilsho	6216	20	C58	C58	NNP
cord-006229-7yoilsho	6216	21	protease	protease	NN
cord-006229-7yoilsho	6216	22	family	family	NN
cord-006229-7yoilsho	6216	23	.	.	.
cord-006229-7yoilsho	6217	1	PaTox	PaTox	NNP
cord-006229-7yoilsho	6217	2	P	P	NNP
cord-006229-7yoilsho	6217	3	contains	contain	VBZ
cord-006229-7yoilsho	6217	4	the	the	DT
cord-006229-7yoilsho	6217	5	conserved	conserved	JJ
cord-006229-7yoilsho	6217	6	catalytic	catalytic	JJ
cord-006229-7yoilsho	6217	7	triade	triade	NN
cord-006229-7yoilsho	6217	8	(	(	-LRB-
cord-006229-7yoilsho	6217	9	C	C	NNP
cord-006229-7yoilsho	6217	10	/	/	SYM
cord-006229-7yoilsho	6217	11	H	H	NNP
cord-006229-7yoilsho	6217	12	/	/	SYM
cord-006229-7yoilsho	6217	13	D	D	NNP
cord-006229-7yoilsho	6217	14	)	)	-RRB-
cord-006229-7yoilsho	6217	15	of	of	IN
cord-006229-7yoilsho	6217	16	papain	papain	NN
cord-006229-7yoilsho	6217	17	-	-	HYPH
cord-006229-7yoilsho	6217	18	like	like	JJ
cord-006229-7yoilsho	6217	19	cysteine	cysteine	NN
cord-006229-7yoilsho	6217	20	proteases	protease	NNS
cord-006229-7yoilsho	6217	21	and	and	CC
cord-006229-7yoilsho	6217	22	shares	share	NNS
cord-006229-7yoilsho	6217	23	sequence	sequence	NN
cord-006229-7yoilsho	6217	24	similarity	similarity	NN
cord-006229-7yoilsho	6217	25	with	with	IN
cord-006229-7yoilsho	6217	26	effectors	effector	NNS
cord-006229-7yoilsho	6217	27	from	from	IN
cord-006229-7yoilsho	6217	28	Yersinia	Yersinia	NNP
cord-006229-7yoilsho	6217	29	pestis	pestis	NN
cord-006229-7yoilsho	6217	30	(	(	-LRB-
cord-006229-7yoilsho	6217	31	Yersinia	Yersinia	NNP
cord-006229-7yoilsho	6217	32	outer	outer	JJ
cord-006229-7yoilsho	6217	33	protein	protein	NN
cord-006229-7yoilsho	6217	34	YopT	YopT	NNP
cord-006229-7yoilsho	6217	35	)	)	-RRB-
cord-006229-7yoilsho	6217	36	and	and	CC
cord-006229-7yoilsho	6217	37	Pseudomonas	Pseudomonas	NNP
cord-006229-7yoilsho	6217	38	syringae	syringae	NN
cord-006229-7yoilsho	6217	39	(	(	-LRB-
cord-006229-7yoilsho	6217	40	avirulence	avirulence	NNP
cord-006229-7yoilsho	6217	41	protein	protein	NN
cord-006229-7yoilsho	6217	42	AvrPphB	AvrPphB	NNP
cord-006229-7yoilsho	6217	43	)	)	-RRB-
cord-006229-7yoilsho	6217	44	.	.	.
cord-006229-7yoilsho	6218	1	Transient	transient	JJ
cord-006229-7yoilsho	6218	2	expression	expression	NN
cord-006229-7yoilsho	6218	3	of	of	IN
cord-006229-7yoilsho	6218	4	PaTox	PaTox	NNP
cord-006229-7yoilsho	6218	5	P	P	NNP
cord-006229-7yoilsho	6218	6	in	in	IN
cord-006229-7yoilsho	6218	7	HeLa	HeLa	NNP
cord-006229-7yoilsho	6218	8	cells	cell	NNS
cord-006229-7yoilsho	6218	9	induces	induce	VBZ
cord-006229-7yoilsho	6218	10	cell	cell	NN
cord-006229-7yoilsho	6218	11	rounding	rounding	NN
cord-006229-7yoilsho	6218	12	and	and	CC
cord-006229-7yoilsho	6218	13	indicates	indicate	VBZ
cord-006229-7yoilsho	6218	14	a	a	DT
cord-006229-7yoilsho	6218	15	cytotoxic	cytotoxic	JJ
cord-006229-7yoilsho	6218	16	potential	potential	NN
cord-006229-7yoilsho	6218	17	of	of	IN
cord-006229-7yoilsho	6218	18	PaTox	PaTox	NNP
cord-006229-7yoilsho	6218	19	P	P	NNP
cord-006229-7yoilsho	6218	20	.	.	.
cord-006229-7yoilsho	6219	1	Incubation	incubation	NN
cord-006229-7yoilsho	6219	2	of	of	IN
cord-006229-7yoilsho	6219	3	PaTox	PaTox	NNP
cord-006229-7yoilsho	6219	4	P	P	NNP
cord-006229-7yoilsho	6219	5	with	with	IN
cord-006229-7yoilsho	6219	6	linearized	linearize	VBN
cord-006229-7yoilsho	6219	7	bovine	bovine	JJ
cord-006229-7yoilsho	6219	8	serum	serum	NN
cord-006229-7yoilsho	6219	9	albumin	albumin	NN
cord-006229-7yoilsho	6219	10	(	(	-LRB-
cord-006229-7yoilsho	6219	11	BSA	BSA	NNP
cord-006229-7yoilsho	6219	12	)	)	-RRB-
cord-006229-7yoilsho	6219	13	results	result	VBZ
cord-006229-7yoilsho	6219	14	in	in	IN
cord-006229-7yoilsho	6219	15	cleavage	cleavage	NN
cord-006229-7yoilsho	6219	16	products	product	NNS
cord-006229-7yoilsho	6219	17	of	of	IN
cord-006229-7yoilsho	6219	18	BSA	BSA	NNP
cord-006229-7yoilsho	6219	19	assuming	assume	VBG
cord-006229-7yoilsho	6219	20	proteolytic	proteolytic	JJ
cord-006229-7yoilsho	6219	21	activity	activity	NN
cord-006229-7yoilsho	6219	22	of	of	IN
cord-006229-7yoilsho	6219	23	PaTox	PaTox	NNP
cord-006229-7yoilsho	6219	24	P	P	NNP
cord-006229-7yoilsho	6219	25	.	.	.
cord-006229-7yoilsho	6220	1	Mutation	mutation	NN
cord-006229-7yoilsho	6220	2	of	of	IN
cord-006229-7yoilsho	6220	3	the	the	DT
cord-006229-7yoilsho	6220	4	catalytic	catalytic	JJ
cord-006229-7yoilsho	6220	5	cysteine	cysteine	NN
cord-006229-7yoilsho	6220	6	in	in	IN
cord-006229-7yoilsho	6220	7	PaTox	PaTox	NNP
cord-006229-7yoilsho	6220	8	P	P	NNP
cord-006229-7yoilsho	6220	9	prevents	prevent	VBZ
cord-006229-7yoilsho	6220	10	cleavage	cleavage	NN
cord-006229-7yoilsho	6220	11	of	of	IN
cord-006229-7yoilsho	6220	12	BSA	BSA	NNP
cord-006229-7yoilsho	6220	13	and	and	CC
cord-006229-7yoilsho	6220	14	blocks	block	VBZ
cord-006229-7yoilsho	6220	15	cytotoxicity	cytotoxicity	NN
cord-006229-7yoilsho	6220	16	.	.	.
cord-006229-7yoilsho	6221	1	We	-PRON-	PRP
cord-006229-7yoilsho	6221	2	were	be	VBD
cord-006229-7yoilsho	6221	3	not	not	RB
cord-006229-7yoilsho	6221	4	able	able	JJ
cord-006229-7yoilsho	6221	5	to	to	TO
cord-006229-7yoilsho	6221	6	observe	observe	VB
cord-006229-7yoilsho	6221	7	autocatalytic	autocatalytic	JJ
cord-006229-7yoilsho	6221	8	cleavage	cleavage	NN
cord-006229-7yoilsho	6221	9	of	of	IN
cord-006229-7yoilsho	6221	10	PaTox	PaTox	NNP
cord-006229-7yoilsho	6221	11	constructs	construct	NNS
cord-006229-7yoilsho	6221	12	under	under	IN
cord-006229-7yoilsho	6221	13	various	various	JJ
cord-006229-7yoilsho	6221	14	conditions	condition	NNS
cord-006229-7yoilsho	6221	15	.	.	.
cord-006229-7yoilsho	6222	1	The	the	DT
cord-006229-7yoilsho	6222	2	intracellular	intracellular	JJ
cord-006229-7yoilsho	6222	3	activity	activity	NN
cord-006229-7yoilsho	6222	4	of	of	IN
cord-006229-7yoilsho	6222	5	the	the	DT
cord-006229-7yoilsho	6222	6	protease	protease	NN
cord-006229-7yoilsho	6222	7	domain	domain	NN
cord-006229-7yoilsho	6222	8	is	be	VBZ
cord-006229-7yoilsho	6222	9	most	most	RBS
cord-006229-7yoilsho	6222	10	likely	likely	RB
cord-006229-7yoilsho	6222	11	involved	involve	VBN
cord-006229-7yoilsho	6222	12	in	in	IN
cord-006229-7yoilsho	6222	13	the	the	DT
cord-006229-7yoilsho	6222	14	pathogenicity	pathogenicity	NN
cord-006229-7yoilsho	6222	15	of	of	IN
cord-006229-7yoilsho	6222	16	PaTox	PaTox	NNP
cord-006229-7yoilsho	6222	17	.	.	.
cord-006229-7yoilsho	6223	1	Vitamin	vitamin	NN
cord-006229-7yoilsho	6223	2	D	d	NN
cord-006229-7yoilsho	6223	3	metabolism	metabolism	NN
cord-006229-7yoilsho	6223	4	-Involved	-involve	VBD
cord-006229-7yoilsho	6223	5	in	in	IN
cord-006229-7yoilsho	6223	6	triazole	triazole	NN
cord-006229-7yoilsho	6223	7	fungicide	fungicide	NN
cord-006229-7yoilsho	6223	8	toxicity	toxicity	NN
cord-006229-7yoilsho	6223	9	?	?	.
cord-006229-7yoilsho	6224	1	A.	A.	NNP
cord-006229-7yoilsho	6224	2	Lehmann	Lehmann	NNP
cord-006229-7yoilsho	6224	3	1	1	CD
cord-006229-7yoilsho	6224	4	1	1	CD
cord-006229-7yoilsho	6224	5	Background	Background	NNP
cord-006229-7yoilsho	6224	6	:	:	:
cord-006229-7yoilsho	6225	1	In	in	IN
cord-006229-7yoilsho	6225	2	a	a	DT
cord-006229-7yoilsho	6225	3	28-day	28-day	CD
cord-006229-7yoilsho	6225	4	rat	rat	NN
cord-006229-7yoilsho	6225	5	feeding	feeding	NN
cord-006229-7yoilsho	6225	6	study	study	NN
cord-006229-7yoilsho	6225	7	with	with	IN
cord-006229-7yoilsho	6225	8	the	the	DT
cord-006229-7yoilsho	6225	9	azole	azole	NNP
cord-006229-7yoilsho	6225	10	fungicides	fungicide	NNS
cord-006229-7yoilsho	6225	11	cyproconazole	cyproconazole	NNP
cord-006229-7yoilsho	6225	12	(	(	-LRB-
cord-006229-7yoilsho	6225	13	C	C	NNP
cord-006229-7yoilsho	6225	14	)	)	-RRB-
cord-006229-7yoilsho	6225	15	,	,	,
cord-006229-7yoilsho	6225	16	epoxiconazole	epoxiconazole	NNP
cord-006229-7yoilsho	6225	17	(	(	-LRB-
cord-006229-7yoilsho	6225	18	E	E	NNP
cord-006229-7yoilsho	6225	19	)	)	-RRB-
cord-006229-7yoilsho	6225	20	,	,	,
cord-006229-7yoilsho	6225	21	propiconazole	propiconazole	NNP
cord-006229-7yoilsho	6225	22	(	(	-LRB-
cord-006229-7yoilsho	6225	23	P	p	NN
cord-006229-7yoilsho	6225	24	)	)	-RRB-
cord-006229-7yoilsho	6225	25	,	,	,
cord-006229-7yoilsho	6225	26	tebuconazole	tebuconazole	NNP
cord-006229-7yoilsho	6225	27	(	(	-LRB-
cord-006229-7yoilsho	6225	28	T	T	NNP
cord-006229-7yoilsho	6225	29	)	)	-RRB-
cord-006229-7yoilsho	6225	30	,	,	,
cord-006229-7yoilsho	6225	31	prochloraz	prochloraz	FW
cord-006229-7yoilsho	6225	32	(	(	-LRB-
cord-006229-7yoilsho	6225	33	Pz	Pz	NNP
cord-006229-7yoilsho	6225	34	)	)	-RRB-
cord-006229-7yoilsho	6225	35	as	as	RB
cord-006229-7yoilsho	6225	36	well	well	RB
cord-006229-7yoilsho	6225	37	as	as	IN
cord-006229-7yoilsho	6225	38	combinations	combination	NNS
cord-006229-7yoilsho	6225	39	C+E	C+E	NNP
cord-006229-7yoilsho	6225	40	and	and	CC
cord-006229-7yoilsho	6225	41	C+E+Pz	C+E+Pz	NNP
cord-006229-7yoilsho	6225	42	,	,	,
cord-006229-7yoilsho	6225	43	a	a	DT
cord-006229-7yoilsho	6225	44	reduction	reduction	NN
cord-006229-7yoilsho	6225	45	of	of	IN
cord-006229-7yoilsho	6225	46	vitamin	vitamin	NN
cord-006229-7yoilsho	6225	47	D	d	NN
cord-006229-7yoilsho	6225	48	(	(	-LRB-
cord-006229-7yoilsho	6225	49	VitD	VitD	NNP
cord-006229-7yoilsho	6225	50	)	)	-RRB-
cord-006229-7yoilsho	6225	51	receptor	receptor	NN
cord-006229-7yoilsho	6225	52	mRNA	mRNA	NNP
cord-006229-7yoilsho	6225	53	levels	level	NNS
cord-006229-7yoilsho	6225	54	was	be	VBD
cord-006229-7yoilsho	6225	55	reproducibly	reproducibly	RB
cord-006229-7yoilsho	6225	56	observed	observe	VBN
cord-006229-7yoilsho	6225	57	in	in	IN
cord-006229-7yoilsho	6225	58	adrenals	adrenal	NNS
cord-006229-7yoilsho	6225	59	for	for	IN
cord-006229-7yoilsho	6225	60	C	C	NNP
cord-006229-7yoilsho	6225	61	,	,	,
cord-006229-7yoilsho	6225	62	E	E	NNP
cord-006229-7yoilsho	6225	63	and	and	CC
cord-006229-7yoilsho	6225	64	P.	P.	NNP
cord-006229-7yoilsho	6225	65	Transcription	Transcription	NNP
cord-006229-7yoilsho	6225	66	of	of	IN
cord-006229-7yoilsho	6225	67	various	various	JJ
cord-006229-7yoilsho	6225	68	enzymes	enzyme	NNS
cord-006229-7yoilsho	6225	69	related	relate	VBN
cord-006229-7yoilsho	6225	70	to	to	IN
cord-006229-7yoilsho	6225	71	VitD	VitD	NNP
cord-006229-7yoilsho	6225	72	homeostasis	homeostasis	NN
cord-006229-7yoilsho	6225	73	(	(	-LRB-
cord-006229-7yoilsho	6225	74	including	include	VBG
cord-006229-7yoilsho	6225	75	Cyp2r1	cyp2r1	ADD
cord-006229-7yoilsho	6225	76	,	,	,
cord-006229-7yoilsho	6225	77	Gc	Gc	NNP
cord-006229-7yoilsho	6225	78	,	,	,
cord-006229-7yoilsho	6225	79	Cyp3a	Cyp3a	NNP
cord-006229-7yoilsho	6225	80	,	,	,
cord-006229-7yoilsho	6225	81	Ugt1a	Ugt1a	NNP
cord-006229-7yoilsho	6225	82	)	)	-RRB-
cord-006229-7yoilsho	6225	83	in	in	IN
cord-006229-7yoilsho	6225	84	liver	liver	NN
cord-006229-7yoilsho	6225	85	was	be	VBD
cord-006229-7yoilsho	6225	86	also	also	RB
cord-006229-7yoilsho	6225	87	affected	affect	VBN
cord-006229-7yoilsho	6225	88	,	,	,
cord-006229-7yoilsho	6225	89	while	while	IN
cord-006229-7yoilsho	6225	90	initial	initial	JJ
cord-006229-7yoilsho	6225	91	indications	indication	NNS
cord-006229-7yoilsho	6225	92	for	for	IN
cord-006229-7yoilsho	6225	93	modulation	modulation	NN
cord-006229-7yoilsho	6225	94	of	of	IN
cord-006229-7yoilsho	6225	95	renal	renal	JJ
cord-006229-7yoilsho	6225	96	Cyp24a1	Cyp24a1	NNP
cord-006229-7yoilsho	6225	97	and	and	CC
cord-006229-7yoilsho	6225	98	renal	renal	JJ
cord-006229-7yoilsho	6225	99	and	and	CC
cord-006229-7yoilsho	6225	100	hepatic	hepatic	JJ
cord-006229-7yoilsho	6225	101	Cyp27b1	cyp27b1	NN
cord-006229-7yoilsho	6225	102	could	could	MD
cord-006229-7yoilsho	6225	103	not	not	RB
cord-006229-7yoilsho	6225	104	be	be	VB
cord-006229-7yoilsho	6225	105	confirmed	confirm	VBN
cord-006229-7yoilsho	6225	106	.	.	.
cord-006229-7yoilsho	6226	1	A	a	DT
cord-006229-7yoilsho	6226	2	possible	possible	JJ
cord-006229-7yoilsho	6226	3	induction	induction	NN
cord-006229-7yoilsho	6226	4	of	of	IN
cord-006229-7yoilsho	6226	5	parathormone	parathormone	NN
cord-006229-7yoilsho	6226	6	(	(	-LRB-
cord-006229-7yoilsho	6226	7	PTH	PTH	NNP
cord-006229-7yoilsho	6226	8	)	)	-RRB-
cord-006229-7yoilsho	6226	9	was	be	VBD
cord-006229-7yoilsho	6226	10	noted	note	VBN
cord-006229-7yoilsho	6226	11	for	for	IN
cord-006229-7yoilsho	6226	12	the	the	DT
cord-006229-7yoilsho	6226	13	high	high	JJ
cord-006229-7yoilsho	6226	14	dose	dose	NN
cord-006229-7yoilsho	6226	15	of	of	IN
cord-006229-7yoilsho	6226	16	C	c	NN
cord-006229-7yoilsho	6226	17	,	,	,
cord-006229-7yoilsho	6226	18	but	but	CC
cord-006229-7yoilsho	6226	19	statistical	statistical	JJ
cord-006229-7yoilsho	6226	20	significance	significance	NN
cord-006229-7yoilsho	6226	21	could	could	MD
cord-006229-7yoilsho	6226	22	not	not	RB
cord-006229-7yoilsho	6226	23	be	be	VB
cord-006229-7yoilsho	6226	24	shown	show	VBN
cord-006229-7yoilsho	6226	25	.	.	.
cord-006229-7yoilsho	6227	1	We	-PRON-	PRP
cord-006229-7yoilsho	6227	2	have	have	VBP
cord-006229-7yoilsho	6227	3	now	now	RB
cord-006229-7yoilsho	6227	4	performed	perform	VBN
cord-006229-7yoilsho	6227	5	supporting	support	VBG
cord-006229-7yoilsho	6227	6	analyses	analysis	NNS
cord-006229-7yoilsho	6227	7	for	for	IN
cord-006229-7yoilsho	6227	8	serum	serum	NN
cord-006229-7yoilsho	6227	9	VitD	VitD	NNP
cord-006229-7yoilsho	6227	10	levels	level	NNS
cord-006229-7yoilsho	6227	11	,	,	,
cord-006229-7yoilsho	6227	12	measured	measure	VBD
cord-006229-7yoilsho	6227	13	additional	additional	JJ
cord-006229-7yoilsho	6227	14	transcript	transcript	NN
cord-006229-7yoilsho	6227	15	levels	level	NNS
cord-006229-7yoilsho	6227	16	and	and	CC
cord-006229-7yoilsho	6227	17	will	will	MD
cord-006229-7yoilsho	6227	18	provide	provide	VB
cord-006229-7yoilsho	6227	19	a	a	DT
cord-006229-7yoilsho	6227	20	framework	framework	NN
cord-006229-7yoilsho	6227	21	for	for	IN
cord-006229-7yoilsho	6227	22	the	the	DT
cord-006229-7yoilsho	6227	23	interpretation	interpretation	NN
cord-006229-7yoilsho	6227	24	of	of	IN
cord-006229-7yoilsho	6227	25	the	the	DT
cord-006229-7yoilsho	6227	26	findings	finding	NNS
cord-006229-7yoilsho	6227	27	.	.	.
cord-006229-7yoilsho	6228	1	Methods	method	NNS
cord-006229-7yoilsho	6228	2	:	:	:
cord-006229-7yoilsho	6228	3	Male	male	JJ
cord-006229-7yoilsho	6228	4	Wistar	Wistar	NNP
cord-006229-7yoilsho	6228	5	rats	rat	NNS
cord-006229-7yoilsho	6228	6	(	(	-LRB-
cord-006229-7yoilsho	6228	7	n=5	n=5	RB
cord-006229-7yoilsho	6228	8	for	for	IN
cord-006229-7yoilsho	6228	9	single	single	JJ
cord-006229-7yoilsho	6228	10	substances	substance	NNS
cord-006229-7yoilsho	6228	11	,	,	,
cord-006229-7yoilsho	6228	12	n=10	n=10	NNP
cord-006229-7yoilsho	6228	13	for	for	IN
cord-006229-7yoilsho	6228	14	combinations	combination	NNS
cord-006229-7yoilsho	6228	15	)	)	-RRB-
cord-006229-7yoilsho	6228	16	were	be	VBD
cord-006229-7yoilsho	6228	17	treated	treat	VBN
cord-006229-7yoilsho	6228	18	for	for	IN
cord-006229-7yoilsho	6228	19	28	28	CD
cord-006229-7yoilsho	6228	20	days	day	NNS
cord-006229-7yoilsho	6228	21	at	at	IN
cord-006229-7yoilsho	6228	22	dose	dose	NN
cord-006229-7yoilsho	6228	23	levels	level	NNS
cord-006229-7yoilsho	6228	24	tested	test	VBN
cord-006229-7yoilsho	6228	25	based	base	VBN
cord-006229-7yoilsho	6228	26	on	on	IN
cord-006229-7yoilsho	6228	27	NOAELs	noael	NNS
cord-006229-7yoilsho	6228	28	from	from	IN
cord-006229-7yoilsho	6228	29	90-day	90-day	CD
cord-006229-7yoilsho	6228	30	subchronic	subchronic	JJ
cord-006229-7yoilsho	6228	31	feeding	feeding	NN
cord-006229-7yoilsho	6228	32	studies	study	NNS
cord-006229-7yoilsho	6228	33	and	and	CC
cord-006229-7yoilsho	6228	34	ranged	range	VBD
cord-006229-7yoilsho	6228	35	from	from	IN
cord-006229-7yoilsho	6228	36	NOAEL/100	NOAEL/100	NNP
cord-006229-7yoilsho	6228	37	to	to	IN
cord-006229-7yoilsho	6228	38	NOAELx10	NOAELx10	NNP
cord-006229-7yoilsho	6228	39	.	.	.
cord-006229-7yoilsho	6229	1	Quantitative	quantitative	JJ
cord-006229-7yoilsho	6229	2	RT	RT	NNP
cord-006229-7yoilsho	6229	3	-	-	HYPH
cord-006229-7yoilsho	6229	4	PCR	PCR	NNP
cord-006229-7yoilsho	6229	5	analyses	analysis	NNS
cord-006229-7yoilsho	6229	6	were	be	VBD
cord-006229-7yoilsho	6229	7	performed	perform	VBN
cord-006229-7yoilsho	6229	8	on	on	IN
cord-006229-7yoilsho	6229	9	organ	organ	NN
cord-006229-7yoilsho	6229	10	samples	sample	NNS
cord-006229-7yoilsho	6229	11	obtained	obtain	VBN
cord-006229-7yoilsho	6229	12	at	at	IN
cord-006229-7yoilsho	6229	13	sacrifice	sacrifice	NN
cord-006229-7yoilsho	6229	14	.	.	.
cord-006229-7yoilsho	6230	1	Serum	serum	NN
cord-006229-7yoilsho	6230	2	VitD	VitD	NNP
cord-006229-7yoilsho	6230	3	levels	level	NNS
cord-006229-7yoilsho	6230	4	were	be	VBD
cord-006229-7yoilsho	6230	5	determined	determine	VBN
cord-006229-7yoilsho	6230	6	using	use	VBG
cord-006229-7yoilsho	6230	7	the	the	DT
cord-006229-7yoilsho	6230	8	total	total	NN
cord-006229-7yoilsho	6230	9	(	(	-LRB-
cord-006229-7yoilsho	6230	10	25-OH	25-oh	CD
cord-006229-7yoilsho	6230	11	)	)	-RRB-
cord-006229-7yoilsho	6231	1	Vitamin	vitamin	NN
cord-006229-7yoilsho	6231	2	D	d	NN
cord-006229-7yoilsho	6231	3	ELISA	ELISA	NNP
cord-006229-7yoilsho	6231	4	(	(	-LRB-
cord-006229-7yoilsho	6231	5	DRG	DRG	NNP
cord-006229-7yoilsho	6231	6	Instruments	Instruments	NNPS
cord-006229-7yoilsho	6231	7	GmbH	GmbH	NNP
cord-006229-7yoilsho	6231	8	,	,	,
cord-006229-7yoilsho	6231	9	Marburg	Marburg	NNP
cord-006229-7yoilsho	6231	10	,	,	,
cord-006229-7yoilsho	6231	11	Germany	Germany	NNP
cord-006229-7yoilsho	6231	12	)	)	-RRB-
cord-006229-7yoilsho	6231	13	.	.	.
cord-006229-7yoilsho	6232	1	Results	result	NNS
cord-006229-7yoilsho	6232	2	:	:	:
cord-006229-7yoilsho	6233	1	The	the	DT
cord-006229-7yoilsho	6233	2	ELISA	ELISA	NNP
cord-006229-7yoilsho	6233	3	established	establish	VBD
cord-006229-7yoilsho	6233	4	for	for	IN
cord-006229-7yoilsho	6233	5	diagnostic	diagnostic	JJ
cord-006229-7yoilsho	6233	6	analysis	analysis	NN
cord-006229-7yoilsho	6233	7	of	of	IN
cord-006229-7yoilsho	6233	8	human	human	JJ
cord-006229-7yoilsho	6233	9	serum	serum	NN
cord-006229-7yoilsho	6233	10	and	and	CC
cord-006229-7yoilsho	6233	11	plasma	plasma	NN
cord-006229-7yoilsho	6233	12	samples	sample	NNS
cord-006229-7yoilsho	6233	13	could	could	MD
cord-006229-7yoilsho	6233	14	be	be	VB
cord-006229-7yoilsho	6233	15	applied	apply	VBN
cord-006229-7yoilsho	6233	16	to	to	IN
cord-006229-7yoilsho	6233	17	rat	rat	NN
cord-006229-7yoilsho	6233	18	serum	serum	NN
cord-006229-7yoilsho	6233	19	.	.	.
cord-006229-7yoilsho	6234	1	VitD	VitD	NNP
cord-006229-7yoilsho	6234	2	levels	level	NNS
cord-006229-7yoilsho	6234	3	in	in	IN
cord-006229-7yoilsho	6234	4	control	control	NN
cord-006229-7yoilsho	6234	5	animals	animal	NNS
cord-006229-7yoilsho	6234	6	(	(	-LRB-
cord-006229-7yoilsho	6235	1	n=30	n=30	NNP
cord-006229-7yoilsho	6235	2	)	)	-RRB-
cord-006229-7yoilsho	6235	3	were	be	VBD
cord-006229-7yoilsho	6235	4	64.7±8.3	64.7±8.3	CD
cord-006229-7yoilsho	6235	5	ng	ng	NNP
cord-006229-7yoilsho	6235	6	/	/	SYM
cord-006229-7yoilsho	6235	7	mL	ml	NN
cord-006229-7yoilsho	6236	1	(	(	-LRB-
cord-006229-7yoilsho	6236	2	min	min	NNP
cord-006229-7yoilsho	6236	3	/	/	SYM
cord-006229-7yoilsho	6236	4	max	max	NNP
cord-006229-7yoilsho	6236	5	:	:	:
cord-006229-7yoilsho	6236	6	48/78	48/78	CD
cord-006229-7yoilsho	6236	7	ng	ng	NNP
cord-006229-7yoilsho	6236	8	/	/	SYM
cord-006229-7yoilsho	6236	9	mL	mL	NNP
cord-006229-7yoilsho	6236	10	)	)	-RRB-
cord-006229-7yoilsho	6236	11	,	,	.
cord-006229-7yoilsho	6237	1	i.e.	i.e.	FW
cord-006229-7yoilsho	6237	2	in	in	IN
cord-006229-7yoilsho	6237	3	the	the	DT
cord-006229-7yoilsho	6237	4	range	range	NN
cord-006229-7yoilsho	6237	5	of	of	IN
cord-006229-7yoilsho	6237	6	values	value	NNS
cord-006229-7yoilsho	6237	7	reported	report	VBN
cord-006229-7yoilsho	6237	8	previously	previously	RB
cord-006229-7yoilsho	6237	9	for	for	IN
cord-006229-7yoilsho	6237	10	rats	rat	NNS
cord-006229-7yoilsho	6237	11	.	.	.
cord-006229-7yoilsho	6238	1	For	for	IN
cord-006229-7yoilsho	6238	2	the	the	DT
cord-006229-7yoilsho	6238	3	high	high	JJ
cord-006229-7yoilsho	6238	4	dose	dose	NN
cord-006229-7yoilsho	6238	5	of	of	IN
cord-006229-7yoilsho	6238	6	C	c	NN
cord-006229-7yoilsho	6238	7	(	(	-LRB-
cord-006229-7yoilsho	6238	8	1000	1000	CD
cord-006229-7yoilsho	6238	9	ppm	ppm	NN
cord-006229-7yoilsho	6238	10	in	in	IN
cord-006229-7yoilsho	6238	11	food	food	NN
cord-006229-7yoilsho	6238	12	,	,	,
cord-006229-7yoilsho	6238	13	n=5	n=5	NNP
cord-006229-7yoilsho	6238	14	)	)	-RRB-
cord-006229-7yoilsho	6238	15	,	,	,
cord-006229-7yoilsho	6238	16	there	there	EX
cord-006229-7yoilsho	6238	17	was	be	VBD
cord-006229-7yoilsho	6238	18	a	a	DT
cord-006229-7yoilsho	6238	19	statistically	statistically	RB
cord-006229-7yoilsho	6238	20	nonsignificant	nonsignificant	JJ
cord-006229-7yoilsho	6238	21	reduction	reduction	NN
cord-006229-7yoilsho	6238	22	of	of	IN
cord-006229-7yoilsho	6238	23	VitD	VitD	NNP
cord-006229-7yoilsho	6238	24	levels	level	NNS
cord-006229-7yoilsho	6238	25	to	to	IN
cord-006229-7yoilsho	6238	26	71.3±17.6	71.3±17.6	CD
cord-006229-7yoilsho	6238	27	%	%	NN
cord-006229-7yoilsho	6238	28	of	of	IN
cord-006229-7yoilsho	6238	29	the	the	DT
cord-006229-7yoilsho	6238	30	concurrent	concurrent	JJ
cord-006229-7yoilsho	6238	31	control	control	NN
cord-006229-7yoilsho	6238	32	(	(	-LRB-
cord-006229-7yoilsho	6238	33	n=5	n=5	NNP
cord-006229-7yoilsho	6238	34	)	)	-RRB-
cord-006229-7yoilsho	6238	35	.	.	.
cord-006229-7yoilsho	6239	1	However	however	RB
cord-006229-7yoilsho	6239	2	,	,	,
cord-006229-7yoilsho	6239	3	for	for	IN
cord-006229-7yoilsho	6239	4	4	4	CD
cord-006229-7yoilsho	6239	5	of	of	IN
cord-006229-7yoilsho	6239	6	5	5	CD
cord-006229-7yoilsho	6239	7	animals	animal	NNS
cord-006229-7yoilsho	6239	8	of	of	IN
cord-006229-7yoilsho	6239	9	this	this	DT
cord-006229-7yoilsho	6239	10	group	group	NN
cord-006229-7yoilsho	6239	11	,	,	,
cord-006229-7yoilsho	6239	12	measured	measure	VBN
cord-006229-7yoilsho	6239	13	VitD	VitD	NNP
cord-006229-7yoilsho	6239	14	level	level	NN
cord-006229-7yoilsho	6239	15	were	be	VBD
cord-006229-7yoilsho	6239	16	below	below	IN
cord-006229-7yoilsho	6239	17	the	the	DT
cord-006229-7yoilsho	6239	18	range	range	NN
cord-006229-7yoilsho	6239	19	observed	observe	VBN
cord-006229-7yoilsho	6239	20	in	in	IN
cord-006229-7yoilsho	6239	21	pooled	pool	VBN
cord-006229-7yoilsho	6239	22	controls	control	NNS
cord-006229-7yoilsho	6239	23	(	(	-LRB-
cord-006229-7yoilsho	6239	24	n=30	n=30	NNP
cord-006229-7yoilsho	6239	25	)	)	-RRB-
cord-006229-7yoilsho	6239	26	.	.	.
cord-006229-7yoilsho	6240	1	An	an	DT
cord-006229-7yoilsho	6240	2	according	accord	VBG
cord-006229-7yoilsho	6240	3	follow	follow	NN
cord-006229-7yoilsho	6240	4	-	-	HYPH
cord-006229-7yoilsho	6240	5	up	up	NN
cord-006229-7yoilsho	6240	6	is	be	VBZ
cord-006229-7yoilsho	6240	7	ongoing	ongoing	JJ
cord-006229-7yoilsho	6240	8	.	.	.
cord-006229-7yoilsho	6241	1	qRT	qRT	NNP
cord-006229-7yoilsho	6241	2	-	-	HYPH
cord-006229-7yoilsho	6241	3	PCR	PCR	NNP
cord-006229-7yoilsho	6241	4	analysis	analysis	NN
cord-006229-7yoilsho	6241	5	of	of	IN
cord-006229-7yoilsho	6241	6	adrenal	adrenal	JJ
cord-006229-7yoilsho	6241	7	tissue	tissue	NN
cord-006229-7yoilsho	6241	8	showed	show	VBD
cord-006229-7yoilsho	6241	9	deregulation	deregulation	NN
cord-006229-7yoilsho	6241	10	of	of	IN
cord-006229-7yoilsho	6241	11	apoptosis	apoptosis	NN
cord-006229-7yoilsho	6241	12	related	relate	VBN
cord-006229-7yoilsho	6241	13	genes	gene	NNS
cord-006229-7yoilsho	6241	14	(	(	-LRB-
cord-006229-7yoilsho	6241	15	p21	p21	NN
cord-006229-7yoilsho	6241	16	for	for	IN
cord-006229-7yoilsho	6241	17	C	C	NNP
cord-006229-7yoilsho	6241	18	,	,	,
cord-006229-7yoilsho	6241	19	E	E	NNP
cord-006229-7yoilsho	6241	20	and	and	CC
cord-006229-7yoilsho	6241	21	Pz	Pz	NNP
cord-006229-7yoilsho	6241	22	;	;	:
cord-006229-7yoilsho	6241	23	Cdk1	Cdk1	NNP
cord-006229-7yoilsho	6241	24	and	and	CC
cord-006229-7yoilsho	6241	25	Gadd45a	Gadd45a	NNP
cord-006229-7yoilsho	6241	26	for	for	IN
cord-006229-7yoilsho	6241	27	E	E	NNP
cord-006229-7yoilsho	6241	28	;	;	:
cord-006229-7yoilsho	6241	29	Cdkn1c	cdkn1c	VB
cord-006229-7yoilsho	6241	30	for	for	IN
cord-006229-7yoilsho	6241	31	C	C	NNP
cord-006229-7yoilsho	6241	32	)	)	-RRB-
cord-006229-7yoilsho	6241	33	,	,	,
cord-006229-7yoilsho	6241	34	which	which	WDT
cord-006229-7yoilsho	6241	35	is	be	VBZ
cord-006229-7yoilsho	6241	36	in	in	IN
cord-006229-7yoilsho	6241	37	agreement	agreement	NN
cord-006229-7yoilsho	6241	38	with	with	IN
cord-006229-7yoilsho	6241	39	an	an	DT
cord-006229-7yoilsho	6241	40	involvement	involvement	NN
cord-006229-7yoilsho	6241	41	of	of	IN
cord-006229-7yoilsho	6241	42	VitD	VitD	NNP
cord-006229-7yoilsho	6241	43	in	in	IN
cord-006229-7yoilsho	6241	44	the	the	DT
cord-006229-7yoilsho	6241	45	autocrine	autocrine	NN
cord-006229-7yoilsho	6241	46	/	/	SYM
cord-006229-7yoilsho	6241	47	paracrine	paracrine	NN
cord-006229-7yoilsho	6241	48	regulation	regulation	NN
cord-006229-7yoilsho	6241	49	of	of	IN
cord-006229-7yoilsho	6241	50	cell	cell	NN
cord-006229-7yoilsho	6241	51	proliferation	proliferation	NN
cord-006229-7yoilsho	6241	52	.	.	.
cord-006229-7yoilsho	6242	1	Conclusion	conclusion	NN
cord-006229-7yoilsho	6242	2	:	:	:
cord-006229-7yoilsho	6242	3	Reduction	reduction	NN
cord-006229-7yoilsho	6242	4	of	of	IN
cord-006229-7yoilsho	6242	5	circulating	circulate	VBG
cord-006229-7yoilsho	6242	6	VitD	VitD	NNP
cord-006229-7yoilsho	6242	7	levels	level	NNS
cord-006229-7yoilsho	6242	8	would	would	MD
cord-006229-7yoilsho	6242	9	be	be	VB
cord-006229-7yoilsho	6242	10	plausible	plausible	JJ
cord-006229-7yoilsho	6242	11	as	as	IN
cord-006229-7yoilsho	6242	12	a	a	DT
cord-006229-7yoilsho	6242	13	result	result	NN
cord-006229-7yoilsho	6242	14	of	of	IN
cord-006229-7yoilsho	6242	15	induction	induction	NN
cord-006229-7yoilsho	6242	16	of	of	IN
cord-006229-7yoilsho	6242	17	hepatic	hepatic	NNP
cord-006229-7yoilsho	6242	18	Cyp3a1/2	Cyp3a1/2	NNPS
cord-006229-7yoilsho	6242	19	and	and	CC
cord-006229-7yoilsho	6242	20	Ugt1a	Ugt1a	NNP
cord-006229-7yoilsho	6242	21	.	.	.
cord-006229-7yoilsho	6243	1	However	however	RB
cord-006229-7yoilsho	6243	2	,	,	,
cord-006229-7yoilsho	6243	3	this	this	DT
cord-006229-7yoilsho	6243	4	could	could	MD
cord-006229-7yoilsho	6243	5	not	not	RB
cord-006229-7yoilsho	6243	6	be	be	VB
cord-006229-7yoilsho	6243	7	confirmed	confirm	VBN
cord-006229-7yoilsho	6243	8	by	by	IN
cord-006229-7yoilsho	6243	9	ELISA	ELISA	NNP
cord-006229-7yoilsho	6243	10	as	as	IN
cord-006229-7yoilsho	6243	11	a	a	DT
cord-006229-7yoilsho	6243	12	general	general	JJ
cord-006229-7yoilsho	6243	13	mechanism	mechanism	NN
cord-006229-7yoilsho	6243	14	for	for	IN
cord-006229-7yoilsho	6243	15	all	all	DT
cord-006229-7yoilsho	6243	16	azole	azole	NNP
cord-006229-7yoilsho	6243	17	fungicides	fungicide	NNS
cord-006229-7yoilsho	6243	18	under	under	IN
cord-006229-7yoilsho	6243	19	investigation	investigation	NN
cord-006229-7yoilsho	6243	20	.	.	.
cord-006229-7yoilsho	6244	1	Only	only	RB
cord-006229-7yoilsho	6244	2	for	for	IN
cord-006229-7yoilsho	6244	3	rats	rat	NNS
cord-006229-7yoilsho	6244	4	fed	feed	VBN
cord-006229-7yoilsho	6244	5	with	with	IN
cord-006229-7yoilsho	6244	6	1000ppm	1000ppm	CD
cord-006229-7yoilsho	6244	7	cyproconazole	cyproconazole	NNP
cord-006229-7yoilsho	6244	8	,	,	,
cord-006229-7yoilsho	6244	9	there	there	EX
cord-006229-7yoilsho	6244	10	were	be	VBD
cord-006229-7yoilsho	6244	11	indications	indication	NNS
cord-006229-7yoilsho	6244	12	for	for	IN
cord-006229-7yoilsho	6244	13	a	a	DT
cord-006229-7yoilsho	6244	14	moderate	moderate	JJ
cord-006229-7yoilsho	6244	15	reduction	reduction	NN
cord-006229-7yoilsho	6244	16	of	of	IN
cord-006229-7yoilsho	6244	17	25-OH	25-oh	CD
cord-006229-7yoilsho	6244	18	Vitamin	vitamin	NN
cord-006229-7yoilsho	6244	19	D	d	NN
cord-006229-7yoilsho	6244	20	,	,	,
cord-006229-7yoilsho	6244	21	which	which	WDT
cord-006229-7yoilsho	6244	22	would	would	MD
cord-006229-7yoilsho	6244	23	correlate	correlate	VB
cord-006229-7yoilsho	6244	24	with	with	IN
cord-006229-7yoilsho	6244	25	the	the	DT
cord-006229-7yoilsho	6244	26	previously	previously	RB
cord-006229-7yoilsho	6244	27	reported	report	VBN
cord-006229-7yoilsho	6244	28	moderate	moderate	JJ
cord-006229-7yoilsho	6244	29	increase	increase	NN
cord-006229-7yoilsho	6244	30	in	in	IN
cord-006229-7yoilsho	6244	31	serum	serum	NN
cord-006229-7yoilsho	6244	32	PTH	PTH	NNP
cord-006229-7yoilsho	6244	33	for	for	IN
cord-006229-7yoilsho	6244	34	this	this	DT
cord-006229-7yoilsho	6244	35	group	group	NN
cord-006229-7yoilsho	6244	36	.	.	.
cord-006229-7yoilsho	6245	1	Hansen	Hansen	NNP
cord-006229-7yoilsho	6245	2	's	's	POS
cord-006229-7yoilsho	6245	3	disease	disease	NN
cord-006229-7yoilsho	6245	4	during	during	IN
cord-006229-7yoilsho	6245	5	pregnancy	pregnancy	NN
cord-006229-7yoilsho	6245	6	and	and	CC
cord-006229-7yoilsho	6245	7	lactation	lactation	NN
cord-006229-7yoilsho	6245	8	:	:	:
cord-006229-7yoilsho	6245	9	two	two	CD
cord-006229-7yoilsho	6245	10	babies	baby	NNS
cord-006229-7yoilsho	6245	11	born	bear	VBN
cord-006229-7yoilsho	6245	12	to	to	IN
cord-006229-7yoilsho	6245	13	a	a	DT
cord-006229-7yoilsho	6245	14	mother	mother	NN
cord-006229-7yoilsho	6245	15	using	use	VBG
cord-006229-7yoilsho	6245	16	antileprosy	antileprosy	NN
cord-006229-7yoilsho	6245	17	drugs	drug	NNS
cord-006229-7yoilsho	6245	18	Z.	Z.	NNP
cord-006229-7yoilsho	6245	19	Ozturk	Ozturk	NNP
cord-006229-7yoilsho	6245	20	Hansen	Hansen	NNP
cord-006229-7yoilsho	6245	21	's	's	POS
cord-006229-7yoilsho	6245	22	disease	disease	NN
cord-006229-7yoilsho	6245	23	,	,	,
cord-006229-7yoilsho	6245	24	also	also	RB
cord-006229-7yoilsho	6245	25	known	know	VBN
cord-006229-7yoilsho	6245	26	as	as	IN
cord-006229-7yoilsho	6245	27	leprosy	leprosy	NN
cord-006229-7yoilsho	6245	28	,	,	,
cord-006229-7yoilsho	6245	29	during	during	IN
cord-006229-7yoilsho	6245	30	pregnancy	pregnancy	NN
cord-006229-7yoilsho	6245	31	has	have	VBZ
cord-006229-7yoilsho	6245	32	been	be	VBN
cord-006229-7yoilsho	6245	33	rarely	rarely	RB
cord-006229-7yoilsho	6245	34	reported	report	VBN
cord-006229-7yoilsho	6245	35	in	in	IN
cord-006229-7yoilsho	6245	36	Europe	Europe	NNP
cord-006229-7yoilsho	6245	37	and	and	CC
cord-006229-7yoilsho	6245	38	United	United	NNP
cord-006229-7yoilsho	6245	39	States	States	NNP
cord-006229-7yoilsho	6245	40	.	.	.
cord-006229-7yoilsho	6246	1	Early	early	JJ
cord-006229-7yoilsho	6246	2	diagnosis	diagnosis	NN
cord-006229-7yoilsho	6246	3	is	be	VBZ
cord-006229-7yoilsho	6246	4	important	important	JJ
cord-006229-7yoilsho	6246	5	,	,	,
cord-006229-7yoilsho	6246	6	and	and	CC
cord-006229-7yoilsho	6246	7	medication	medication	NN
cord-006229-7yoilsho	6246	8	can	can	MD
cord-006229-7yoilsho	6246	9	decrease	decrease	VB
cord-006229-7yoilsho	6246	10	the	the	DT
cord-006229-7yoilsho	6246	11	risk	risk	NN
cord-006229-7yoilsho	6246	12	of	of	IN
cord-006229-7yoilsho	6246	13	those	those	DT
cord-006229-7yoilsho	6246	14	living	live	VBG
cord-006229-7yoilsho	6246	15	with	with	IN
cord-006229-7yoilsho	6246	16	leprosy	leprosy	NN
cord-006229-7yoilsho	6246	17	patients	patient	NNS
cord-006229-7yoilsho	6246	18	from	from	IN
cord-006229-7yoilsho	6246	19	acquiring	acquire	VBG
cord-006229-7yoilsho	6246	20	the	the	DT
cord-006229-7yoilsho	6246	21	disease	disease	NN
cord-006229-7yoilsho	6246	22	.	.	.
cord-006229-7yoilsho	6247	1	This	this	DT
cord-006229-7yoilsho	6247	2	report	report	NN
cord-006229-7yoilsho	6247	3	presents	present	VBZ
cord-006229-7yoilsho	6247	4	a	a	DT
cord-006229-7yoilsho	6247	5	case	case	NN
cord-006229-7yoilsho	6247	6	of	of	IN
cord-006229-7yoilsho	6247	7	multidrug	multidrug	NN
cord-006229-7yoilsho	6247	8	antileprosy	antileprosy	NN
cord-006229-7yoilsho	6247	9	therapy	therapy	NN
cord-006229-7yoilsho	6247	10	during	during	IN
cord-006229-7yoilsho	6247	11	pregnancy	pregnancy	NN
cord-006229-7yoilsho	6247	12	and	and	CC
cord-006229-7yoilsho	6247	13	lactation	lactation	NN
cord-006229-7yoilsho	6247	14	.	.	.
cord-006229-7yoilsho	6248	1	A	a	DT
cord-006229-7yoilsho	6248	2	26-year	26-year	JJ
cord-006229-7yoilsho	6248	3	-	-	HYPH
cord-006229-7yoilsho	6248	4	old	old	JJ
cord-006229-7yoilsho	6248	5	multiparous	multiparous	JJ
cord-006229-7yoilsho	6248	6	woman	woman	NN
cord-006229-7yoilsho	6248	7	with	with	IN
cord-006229-7yoilsho	6248	8	a	a	DT
cord-006229-7yoilsho	6248	9	known	know	VBN
cord-006229-7yoilsho	6248	10	case	case	NN
cord-006229-7yoilsho	6248	11	of	of	IN
cord-006229-7yoilsho	6248	12	multibacillary	multibacillary	JJ
cord-006229-7yoilsho	6248	13	leprosy	leprosy	NN
cord-006229-7yoilsho	6248	14	presented	present	VBN
cord-006229-7yoilsho	6248	15	with	with	IN
cord-006229-7yoilsho	6248	16	unplanned	unplanned	JJ
cord-006229-7yoilsho	6248	17	pregnancy	pregnancy	NN
cord-006229-7yoilsho	6248	18	.	.	.
cord-006229-7yoilsho	6249	1	Her	-PRON-	PRP$
cord-006229-7yoilsho	6249	2	pregnancy	pregnancy	NN
cord-006229-7yoilsho	6249	3	was	be	VBD
cord-006229-7yoilsho	6249	4	discovered	discover	VBN
cord-006229-7yoilsho	6249	5	in	in	IN
cord-006229-7yoilsho	6249	6	the	the	DT
cord-006229-7yoilsho	6249	7	9th	9th	JJ
cord-006229-7yoilsho	6249	8	week	week	NN
cord-006229-7yoilsho	6249	9	,	,	,
cord-006229-7yoilsho	6249	10	and	and	CC
cord-006229-7yoilsho	6249	11	she	-PRON-	PRP
cord-006229-7yoilsho	6249	12	has	have	VBZ
cord-006229-7yoilsho	6249	13	been	be	VBN
cord-006229-7yoilsho	6249	14	taking	take	VBG
cord-006229-7yoilsho	6249	15	a	a	DT
cord-006229-7yoilsho	6249	16	multidrug	multidrug	NN
cord-006229-7yoilsho	6249	17	therapy	therapy	NN
cord-006229-7yoilsho	6249	18	(	(	-LRB-
cord-006229-7yoilsho	6249	19	dapsone	dapsone	NNP
cord-006229-7yoilsho	6249	20	100	100	CD
cord-006229-7yoilsho	6249	21	mg	mg	NNP
cord-006229-7yoilsho	6249	22	/	/	SYM
cord-006229-7yoilsho	6249	23	day	day	NN
cord-006229-7yoilsho	6249	24	,	,	,
cord-006229-7yoilsho	6249	25	rifampicin	rifampicin	VBZ
cord-006229-7yoilsho	6249	26	600	600	CD
cord-006229-7yoilsho	6249	27	mg	mg	NNP
cord-006229-7yoilsho	6249	28	/	/	SYM
cord-006229-7yoilsho	6249	29	month	month	NN
cord-006229-7yoilsho	6249	30	,	,	,
cord-006229-7yoilsho	6249	31	clofazimine	clofazimine	NNP
cord-006229-7yoilsho	6249	32	50	50	CD
cord-006229-7yoilsho	6249	33	mg	mg	NNP
cord-006229-7yoilsho	6249	34	/day	/day	:
cord-006229-7yoilsho	6249	35	and	and	CC
cord-006229-7yoilsho	6249	36	clofazimine	clofazimine	NNP
cord-006229-7yoilsho	6249	37	300	300	CD
cord-006229-7yoilsho	6249	38	mg	mg	NNP
cord-006229-7yoilsho	6249	39	/	/	SYM
cord-006229-7yoilsho	6249	40	month	month	NN
cord-006229-7yoilsho	6249	41	)	)	-RRB-
cord-006229-7yoilsho	6249	42	for	for	IN
cord-006229-7yoilsho	6249	43	the	the	DT
cord-006229-7yoilsho	6249	44	past	past	JJ
cord-006229-7yoilsho	6249	45	8	8	CD
cord-006229-7yoilsho	6249	46	months	month	NNS
cord-006229-7yoilsho	6249	47	.	.	.
cord-006229-7yoilsho	6250	1	Diagnosis	diagnosis	NN
cord-006229-7yoilsho	6250	2	of	of	IN
cord-006229-7yoilsho	6250	3	leprosy	leprosy	NN
cord-006229-7yoilsho	6250	4	was	be	VBD
cord-006229-7yoilsho	6250	5	established	establish	VBN
cord-006229-7yoilsho	6250	6	in	in	IN
cord-006229-7yoilsho	6250	7	her	-PRON-	PRP$
cord-006229-7yoilsho	6250	8	previous	previous	JJ
cord-006229-7yoilsho	6250	9	pregnancy	pregnancy	NN
cord-006229-7yoilsho	6250	10	.	.	.
cord-006229-7yoilsho	6251	1	The	the	DT
cord-006229-7yoilsho	6251	2	patient	patient	NN
cord-006229-7yoilsho	6251	3	was	be	VBD
cord-006229-7yoilsho	6251	4	informed	inform	VBN
cord-006229-7yoilsho	6251	5	about	about	IN
cord-006229-7yoilsho	6251	6	the	the	DT
cord-006229-7yoilsho	6251	7	risks	risk	NNS
cord-006229-7yoilsho	6251	8	of	of	IN
cord-006229-7yoilsho	6251	9	drugs	drug	NNS
cord-006229-7yoilsho	6251	10	used	use	VBN
cord-006229-7yoilsho	6251	11	in	in	IN
cord-006229-7yoilsho	6251	12	pregnancy	pregnancy	NN
cord-006229-7yoilsho	6251	13	.	.	.
cord-006229-7yoilsho	6252	1	The	the	DT
cord-006229-7yoilsho	6252	2	treatment	treatment	NN
cord-006229-7yoilsho	6252	3	was	be	VBD
cord-006229-7yoilsho	6252	4	continued	continue	VBN
cord-006229-7yoilsho	6252	5	unchanged	unchanged	JJ
cord-006229-7yoilsho	6252	6	during	during	IN
cord-006229-7yoilsho	6252	7	pregnancy	pregnancy	NN
cord-006229-7yoilsho	6252	8	.	.	.
cord-006229-7yoilsho	6253	1	A	a	DT
cord-006229-7yoilsho	6253	2	detailed	detailed	JJ
cord-006229-7yoilsho	6253	3	fetal	fetal	JJ
cord-006229-7yoilsho	6253	4	ultrasonography	ultrasonography	NN
cord-006229-7yoilsho	6253	5	was	be	VBD
cord-006229-7yoilsho	6253	6	offered	offer	VBN
cord-006229-7yoilsho	6253	7	to	to	TO
cord-006229-7yoilsho	6253	8	scan	scan	VB
cord-006229-7yoilsho	6253	9	the	the	DT
cord-006229-7yoilsho	6253	10	development	development	NN
cord-006229-7yoilsho	6253	11	of	of	IN
cord-006229-7yoilsho	6253	12	the	the	DT
cord-006229-7yoilsho	6253	13	fetus	fetus	NN
cord-006229-7yoilsho	6253	14	at	at	IN
cord-006229-7yoilsho	6253	15	about	about	RB
cord-006229-7yoilsho	6253	16	20	20	CD
cord-006229-7yoilsho	6253	17	weeks	week	NNS
cord-006229-7yoilsho	6253	18	.	.	.
cord-006229-7yoilsho	6254	1	In	in	IN
cord-006229-7yoilsho	6254	2	the	the	DT
cord-006229-7yoilsho	6254	3	8th	8th	NN
cord-006229-7yoilsho	6254	4	,	,	,
cord-006229-7yoilsho	6254	5	22nd	22nd	NN
cord-006229-7yoilsho	6254	6	,	,	,
cord-006229-7yoilsho	6254	7	28th	28th	JJ
cord-006229-7yoilsho	6254	8	weeks	week	NNS
cord-006229-7yoilsho	6254	9	of	of	IN
cord-006229-7yoilsho	6254	10	pregnancy	pregnancy	NN
cord-006229-7yoilsho	6254	11	,	,	,
cord-006229-7yoilsho	6254	12	prenatal	prenatal	JJ
cord-006229-7yoilsho	6254	13	sonographic	sonographic	JJ
cord-006229-7yoilsho	6254	14	examinations	examination	NNS
cord-006229-7yoilsho	6254	15	revealed	reveal	VBD
cord-006229-7yoilsho	6254	16	normal	normal	JJ
cord-006229-7yoilsho	6254	17	fetal	fetal	JJ
cord-006229-7yoilsho	6254	18	growth	growth	NN
cord-006229-7yoilsho	6254	19	and	and	CC
cord-006229-7yoilsho	6254	20	amniotic	amniotic	NN
cord-006229-7yoilsho	6254	21	fluid	fluid	NN
cord-006229-7yoilsho	6254	22	volume	volume	NN
cord-006229-7yoilsho	6254	23	.	.	.
cord-006229-7yoilsho	6255	1	At	at	IN
cord-006229-7yoilsho	6255	2	28	28	CD
cord-006229-7yoilsho	6255	3	weeks	week	NNS
cord-006229-7yoilsho	6255	4	pregnant	pregnant	JJ
cord-006229-7yoilsho	6255	5	,	,	,
cord-006229-7yoilsho	6255	6	she	-PRON-	PRP
cord-006229-7yoilsho	6255	7	was	be	VBD
cord-006229-7yoilsho	6255	8	diagnosed	diagnose	VBN
cord-006229-7yoilsho	6255	9	with	with	IN
cord-006229-7yoilsho	6255	10	gestational	gestational	JJ
cord-006229-7yoilsho	6255	11	diabetes	diabete	NNS
cord-006229-7yoilsho	6255	12	.	.	.
cord-006229-7yoilsho	6256	1	Diabetes	diabetes	NN
cord-006229-7yoilsho	6256	2	did	do	VBD
cord-006229-7yoilsho	6256	3	not	not	RB
cord-006229-7yoilsho	6256	4	cause	cause	VB
cord-006229-7yoilsho	6256	5	any	any	DT
cord-006229-7yoilsho	6256	6	symptoms	symptom	NNS
cord-006229-7yoilsho	6256	7	during	during	IN
cord-006229-7yoilsho	6256	8	pregnancy	pregnancy	NN
cord-006229-7yoilsho	6256	9	,	,	,
cord-006229-7yoilsho	6256	10	and	and	CC
cord-006229-7yoilsho	6256	11	it	-PRON-	PRP
cord-006229-7yoilsho	6256	12	was	be	VBD
cord-006229-7yoilsho	6256	13	controlled	control	VBN
cord-006229-7yoilsho	6256	14	with	with	IN
cord-006229-7yoilsho	6256	15	a	a	DT
cord-006229-7yoilsho	6256	16	reduced	reduce	VBN
cord-006229-7yoilsho	6256	17	-	-	HYPH
cord-006229-7yoilsho	6256	18	calorie	calorie	NN
cord-006229-7yoilsho	6256	19	diet	diet	NN
cord-006229-7yoilsho	6256	20	in	in	IN
cord-006229-7yoilsho	6256	21	a	a	DT
cord-006229-7yoilsho	6256	22	week	week	NN
cord-006229-7yoilsho	6256	23	.	.	.
cord-006229-7yoilsho	6257	1	The	the	DT
cord-006229-7yoilsho	6257	2	patient	patient	NN
cord-006229-7yoilsho	6257	3	delivered	deliver	VBD
cord-006229-7yoilsho	6257	4	a	a	DT
cord-006229-7yoilsho	6257	5	healthy	healthy	JJ
cord-006229-7yoilsho	6257	6	baby	baby	NN
cord-006229-7yoilsho	6257	7	girl	girl	NN
cord-006229-7yoilsho	6257	8	by	by	IN
cord-006229-7yoilsho	6257	9	vaginal	vaginal	JJ
cord-006229-7yoilsho	6257	10	birth	birth	NN
cord-006229-7yoilsho	6257	11	in	in	IN
cord-006229-7yoilsho	6257	12	the	the	DT
cord-006229-7yoilsho	6257	13	39th	39th	JJ
cord-006229-7yoilsho	6257	14	week	week	NN
cord-006229-7yoilsho	6257	15	of	of	IN
cord-006229-7yoilsho	6257	16	gestation	gestation	NN
cord-006229-7yoilsho	6257	17	without	without	IN
cord-006229-7yoilsho	6257	18	perinatal	perinatal	JJ
cord-006229-7yoilsho	6257	19	complications	complication	NNS
cord-006229-7yoilsho	6257	20	.	.	.
cord-006229-7yoilsho	6258	1	The	the	DT
cord-006229-7yoilsho	6258	2	baby	baby	NN
cord-006229-7yoilsho	6258	3	was	be	VBD
cord-006229-7yoilsho	6258	4	also	also	RB
cord-006229-7yoilsho	6258	5	healthy	healthy	JJ
cord-006229-7yoilsho	6259	1	(	(	-LRB-
cord-006229-7yoilsho	6259	2	APGAR	APGAR	NNP
cord-006229-7yoilsho	6259	3	8	8	CD
cord-006229-7yoilsho	6259	4	-	-	HYPH
cord-006229-7yoilsho	6259	5	9,3300	9,3300	NNP
cord-006229-7yoilsho	6259	6	g,51	g,51	NNP
cord-006229-7yoilsho	6259	7	cm	cm	NNP
cord-006229-7yoilsho	6259	8	)	)	-RRB-
cord-006229-7yoilsho	6259	9	,	,	,
cord-006229-7yoilsho	6259	10	and	and	CC
cord-006229-7yoilsho	6259	11	its	-PRON-	PRP$
cord-006229-7yoilsho	6259	12	growth	growth	NN
cord-006229-7yoilsho	6259	13	and	and	CC
cord-006229-7yoilsho	6259	14	development	development	NN
cord-006229-7yoilsho	6259	15	were	be	VBD
cord-006229-7yoilsho	6259	16	normal	normal	JJ
cord-006229-7yoilsho	6259	17	during	during	IN
cord-006229-7yoilsho	6259	18	a	a	DT
cord-006229-7yoilsho	6259	19	6-month	6-month	CD
cord-006229-7yoilsho	6259	20	follow	follow	NN
cord-006229-7yoilsho	6259	21	-	-	HYPH
cord-006229-7yoilsho	6259	22	up	up	NN
cord-006229-7yoilsho	6259	23	period	period	NN
cord-006229-7yoilsho	6259	24	.	.	.
cord-006229-7yoilsho	6260	1	The	the	DT
cord-006229-7yoilsho	6260	2	patient	patient	NN
cord-006229-7yoilsho	6260	3	decided	decide	VBD
cord-006229-7yoilsho	6260	4	to	to	TO
cord-006229-7yoilsho	6260	5	breastfeed	breastfeed	VB
cord-006229-7yoilsho	6260	6	while	while	IN
cord-006229-7yoilsho	6260	7	taking	take	VBG
cord-006229-7yoilsho	6260	8	medication	medication	NN
cord-006229-7yoilsho	6260	9	.	.	.
cord-006229-7yoilsho	6261	1	She	-PRON-	PRP
cord-006229-7yoilsho	6261	2	had	have	VBD
cord-006229-7yoilsho	6261	3	a	a	DT
cord-006229-7yoilsho	6261	4	previous	previous	JJ
cord-006229-7yoilsho	6261	5	experience	experience	NN
cord-006229-7yoilsho	6261	6	with	with	IN
cord-006229-7yoilsho	6261	7	use	use	NN
cord-006229-7yoilsho	6261	8	of	of	IN
cord-006229-7yoilsho	6261	9	anti	anti	JJ
cord-006229-7yoilsho	6261	10	-	-	JJ
cord-006229-7yoilsho	6261	11	leprosy	leprosy	JJ
cord-006229-7yoilsho	6261	12	drugs	drug	NNS
cord-006229-7yoilsho	6261	13	while	while	IN
cord-006229-7yoilsho	6261	14	breastfeeding	breastfeed	VBG
cord-006229-7yoilsho	6261	15	,	,	,
cord-006229-7yoilsho	6261	16	her	-PRON-	PRP$
cord-006229-7yoilsho	6261	17	other	other	JJ
cord-006229-7yoilsho	6261	18	child	child	NN
cord-006229-7yoilsho	6261	19	was	be	VBD
cord-006229-7yoilsho	6261	20	15	15	CD
cord-006229-7yoilsho	6261	21	months	month	NNS
cord-006229-7yoilsho	6261	22	old	old	JJ
cord-006229-7yoilsho	6261	23	and	and	CC
cord-006229-7yoilsho	6261	24	healthy	healthy	JJ
cord-006229-7yoilsho	6261	25	.	.	.
cord-006229-7yoilsho	6262	1	As	as	RB
cord-006229-7yoilsho	6262	2	well	well	RB
cord-006229-7yoilsho	6262	3	as	as	IN
cord-006229-7yoilsho	6262	4	in	in	IN
cord-006229-7yoilsho	6262	5	the	the	DT
cord-006229-7yoilsho	6262	6	first	first	JJ
cord-006229-7yoilsho	6262	7	child	child	NN
cord-006229-7yoilsho	6262	8	,	,	,
cord-006229-7yoilsho	6262	9	skin	skin	NN
cord-006229-7yoilsho	6262	10	discoloration	discoloration	NN
cord-006229-7yoilsho	6262	11	was	be	VBD
cord-006229-7yoilsho	6262	12	observed	observe	VBN
cord-006229-7yoilsho	6262	13	in	in	IN
cord-006229-7yoilsho	6262	14	newborn	newborn	JJ
cord-006229-7yoilsho	6262	15	due	due	IN
cord-006229-7yoilsho	6262	16	to	to	IN
cord-006229-7yoilsho	6262	17	clofazimine	clofazimine	NN
cord-006229-7yoilsho	6262	18	during	during	IN
cord-006229-7yoilsho	6262	19	lactation	lactation	NN
cord-006229-7yoilsho	6262	20	.	.	.
cord-006229-7yoilsho	6263	1	After	after	IN
cord-006229-7yoilsho	6263	2	3	3	CD
cord-006229-7yoilsho	6263	3	months	month	NNS
cord-006229-7yoilsho	6263	4	,	,	,
cord-006229-7yoilsho	6263	5	she	-PRON-	PRP
cord-006229-7yoilsho	6263	6	stopped	stop	VBD
cord-006229-7yoilsho	6263	7	breastfeeding	breastfeed	VBG
cord-006229-7yoilsho	6263	8	,	,	,
cord-006229-7yoilsho	6263	9	and	and	CC
cord-006229-7yoilsho	6263	10	the	the	DT
cord-006229-7yoilsho	6263	11	infant	infant	NN
cord-006229-7yoilsho	6263	12	's	's	POS
cord-006229-7yoilsho	6263	13	skin	skin	NN
cord-006229-7yoilsho	6263	14	changes	change	NNS
cord-006229-7yoilsho	6263	15	were	be	VBD
cord-006229-7yoilsho	6263	16	reversed	reverse	VBN
cord-006229-7yoilsho	6263	17	.	.	.
cord-006229-7yoilsho	6264	1	For	for	IN
cord-006229-7yoilsho	6264	2	pregnant	pregnant	JJ
cord-006229-7yoilsho	6264	3	women	woman	NNS
cord-006229-7yoilsho	6264	4	and	and	CC
cord-006229-7yoilsho	6264	5	practitioners	practitioner	NNS
cord-006229-7yoilsho	6264	6	,	,	,
cord-006229-7yoilsho	6264	7	treatment	treatment	NN
cord-006229-7yoilsho	6264	8	of	of	IN
cord-006229-7yoilsho	6264	9	leprosy	leprosy	NN
cord-006229-7yoilsho	6264	10	in	in	IN
cord-006229-7yoilsho	6264	11	pregnancy	pregnancy	NN
cord-006229-7yoilsho	6264	12	can	can	MD
cord-006229-7yoilsho	6264	13	be	be	VB
cord-006229-7yoilsho	6264	14	complicated	complicated	JJ
cord-006229-7yoilsho	6264	15	.	.	.
cord-006229-7yoilsho	6265	1	Physical	physical	JJ
cord-006229-7yoilsho	6265	2	and	and	CC
cord-006229-7yoilsho	6265	3	neurological	neurological	JJ
cord-006229-7yoilsho	6265	4	damage	damage	NN
cord-006229-7yoilsho	6265	5	may	may	MD
cord-006229-7yoilsho	6265	6	be	be	VB
cord-006229-7yoilsho	6265	7	irreversible	irreversible	JJ
cord-006229-7yoilsho	6265	8	even	even	RB
cord-006229-7yoilsho	6265	9	if	if	IN
cord-006229-7yoilsho	6265	10	cured	cure	VBN
cord-006229-7yoilsho	6265	11	.	.	.
cord-006229-7yoilsho	6266	1	Multidrug	multidrug	JJ
cord-006229-7yoilsho	6266	2	therapy	therapy	NN
cord-006229-7yoilsho	6266	3	consisting	consist	VBG
cord-006229-7yoilsho	6266	4	dapsone	dapsone	NN
cord-006229-7yoilsho	6266	5	,	,	,
cord-006229-7yoilsho	6266	6	rifampicin	rifampicin	NN
cord-006229-7yoilsho	6266	7	and	and	CC
cord-006229-7yoilsho	6266	8	clofazimine	clofazimine	NN
cord-006229-7yoilsho	6266	9	is	be	VBZ
cord-006229-7yoilsho	6266	10	highly	highly	RB
cord-006229-7yoilsho	6266	11	effective	effective	JJ
cord-006229-7yoilsho	6266	12	for	for	IN
cord-006229-7yoilsho	6266	13	people	people	NNS
cord-006229-7yoilsho	6266	14	with	with	IN
cord-006229-7yoilsho	6266	15	leprosy	leprosy	NN
cord-006229-7yoilsho	6266	16	and	and	CC
cord-006229-7yoilsho	6266	17	considered	consider	VBN
cord-006229-7yoilsho	6266	18	safe	safe	JJ
cord-006229-7yoilsho	6266	19	,	,	,
cord-006229-7yoilsho	6266	20	both	both	DT
cord-006229-7yoilsho	6266	21	for	for	IN
cord-006229-7yoilsho	6266	22	the	the	DT
cord-006229-7yoilsho	6266	23	mother	mother	NN
cord-006229-7yoilsho	6266	24	and	and	CC
cord-006229-7yoilsho	6266	25	the	the	DT
cord-006229-7yoilsho	6266	26	child	child	NN
cord-006229-7yoilsho	6266	27	.	.	.
cord-006229-7yoilsho	6267	1	Antileprosy	Antileprosy	NNP
cord-006229-7yoilsho	6267	2	drugs	drug	NNS
cord-006229-7yoilsho	6267	3	are	be	VBP
cord-006229-7yoilsho	6267	4	excreted	excrete	VBN
cord-006229-7yoilsho	6267	5	into	into	IN
cord-006229-7yoilsho	6267	6	human	human	JJ
cord-006229-7yoilsho	6267	7	milk	milk	NN
cord-006229-7yoilsho	6267	8	but	but	CC
cord-006229-7yoilsho	6267	9	there	there	EX
cord-006229-7yoilsho	6267	10	is	be	VBZ
cord-006229-7yoilsho	6267	11	no	no	DT
cord-006229-7yoilsho	6267	12	report	report	NN
cord-006229-7yoilsho	6267	13	of	of	IN
cord-006229-7yoilsho	6267	14	adverse	adverse	JJ
cord-006229-7yoilsho	6267	15	effects	effect	NNS
cord-006229-7yoilsho	6267	16	except	except	IN
cord-006229-7yoilsho	6267	17	for	for	IN
cord-006229-7yoilsho	6267	18	skin	skin	NN
cord-006229-7yoilsho	6267	19	discolouration	discolouration	NN
cord-006229-7yoilsho	6267	20	of	of	IN
cord-006229-7yoilsho	6267	21	the	the	DT
cord-006229-7yoilsho	6267	22	infant	infant	NN
cord-006229-7yoilsho	6267	23	due	due	IN
cord-006229-7yoilsho	6267	24	to	to	IN
cord-006229-7yoilsho	6267	25	clofazimine	clofazimine	NNP
cord-006229-7yoilsho	6267	26	.	.	.
cord-006229-7yoilsho	6268	1	Therefore	therefore	RB
cord-006229-7yoilsho	6268	2	,	,	,
cord-006229-7yoilsho	6268	3	multidrug	multidrug	NN
cord-006229-7yoilsho	6268	4	therapy	therapy	NN
cord-006229-7yoilsho	6268	5	for	for	IN
cord-006229-7yoilsho	6268	6	leprosy	leprosy	NN
cord-006229-7yoilsho	6268	7	patients	patient	NNS
cord-006229-7yoilsho	6268	8	should	should	MD
cord-006229-7yoilsho	6268	9	be	be	VB
cord-006229-7yoilsho	6268	10	continued	continue	VBN
cord-006229-7yoilsho	6268	11	unchanged	unchanged	JJ
cord-006229-7yoilsho	6268	12	during	during	IN
cord-006229-7yoilsho	6268	13	pregnancy	pregnancy	NN
cord-006229-7yoilsho	6268	14	and	and	CC
cord-006229-7yoilsho	6268	15	lactation	lactation	NN
cord-006229-7yoilsho	6268	16	.	.	.
cord-006229-7yoilsho	6269	1	Methods	method	NNS
cord-006229-7yoilsho	6269	2	:	:	:
cord-006229-7yoilsho	6270	1	Individuals	individual	NNS
cord-006229-7yoilsho	6270	2	included	include	VBN
cord-006229-7yoilsho	6270	3	in	in	IN
cord-006229-7yoilsho	6270	4	the	the	DT
cord-006229-7yoilsho	6270	5	analysis	analysis	NN
cord-006229-7yoilsho	6270	6	were	be	VBD
cord-006229-7yoilsho	6270	7	participants	participant	NNS
cord-006229-7yoilsho	6270	8	of	of	IN
cord-006229-7yoilsho	6270	9	the	the	DT
cord-006229-7yoilsho	6270	10	Berlin	Berlin	NNP
cord-006229-7yoilsho	6270	11	Initiative	Initiative	NNP
cord-006229-7yoilsho	6270	12	Study	Study	NNP
cord-006229-7yoilsho	6270	13	(	(	-LRB-
cord-006229-7yoilsho	6270	14	BIS	BIS	NNP
cord-006229-7yoilsho	6270	15	)	)	-RRB-
cord-006229-7yoilsho	6270	16	.	.	.
cord-006229-7yoilsho	6271	1	BIS	BIS	NNP
cord-006229-7yoilsho	6271	2	is	be	VBZ
cord-006229-7yoilsho	6271	3	a	a	DT
cord-006229-7yoilsho	6271	4	population	population	NN
cord-006229-7yoilsho	6271	5	-	-	HYPH
cord-006229-7yoilsho	6271	6	based	base	VBN
cord-006229-7yoilsho	6271	7	prospective	prospective	JJ
cord-006229-7yoilsho	6271	8	cohort	cohort	NN
cord-006229-7yoilsho	6271	9	study	study	NN
cord-006229-7yoilsho	6271	10	initiated	initiate	VBD
cord-006229-7yoilsho	6271	11	in	in	IN
cord-006229-7yoilsho	6271	12	2009	2009	CD
cord-006229-7yoilsho	6271	13	in	in	IN
cord-006229-7yoilsho	6271	14	Berlin	Berlin	NNP
cord-006229-7yoilsho	6271	15	,	,	,
cord-006229-7yoilsho	6271	16	Germany	Germany	NNP
cord-006229-7yoilsho	6271	17	,	,	,
cord-006229-7yoilsho	6271	18	to	to	TO
cord-006229-7yoilsho	6271	19	evaluate	evaluate	VB
cord-006229-7yoilsho	6271	20	kidney	kidney	NN
cord-006229-7yoilsho	6271	21	function	function	NN
cord-006229-7yoilsho	6271	22	in	in	IN
cord-006229-7yoilsho	6271	23	people	people	NNS
cord-006229-7yoilsho	6271	24	≥	≥	CD
cord-006229-7yoilsho	6271	25	70	70	CD
cord-006229-7yoilsho	6271	26	years	year	NNS
cord-006229-7yoilsho	6271	27	.	.	.
cord-006229-7yoilsho	6272	1	Medication	medication	NN
cord-006229-7yoilsho	6272	2	was	be	VBD
cord-006229-7yoilsho	6272	3	assessed	assess	VBN
cord-006229-7yoilsho	6272	4	through	through	IN
cord-006229-7yoilsho	6272	5	personal	personal	JJ
cord-006229-7yoilsho	6272	6	interviews	interview	NNS
cord-006229-7yoilsho	6272	7	and	and	CC
cord-006229-7yoilsho	6272	8	coded	code	VBN
cord-006229-7yoilsho	6272	9	using	use	VBG
cord-006229-7yoilsho	6272	10	the	the	DT
cord-006229-7yoilsho	6272	11	Anatomical	Anatomical	NNP
cord-006229-7yoilsho	6272	12	Therapeutic	Therapeutic	NNP
cord-006229-7yoilsho	6272	13	Chemical	Chemical	NNP
cord-006229-7yoilsho	6272	14	Classification	Classification	NNP
cord-006229-7yoilsho	6272	15	System	System	NNP
cord-006229-7yoilsho	6272	16	.	.	.
cord-006229-7yoilsho	6273	1	For	for	IN
cord-006229-7yoilsho	6273	2	estimation	estimation	NN
cord-006229-7yoilsho	6273	3	of	of	IN
cord-006229-7yoilsho	6273	4	glomerular	glomerular	JJ
cord-006229-7yoilsho	6273	5	filtration	filtration	NN
cord-006229-7yoilsho	6273	6	rate	rate	NN
cord-006229-7yoilsho	6273	7	(	(	-LRB-
cord-006229-7yoilsho	6273	8	eGFR	egfr	NN
cord-006229-7yoilsho	6273	9	)	)	-RRB-
cord-006229-7yoilsho	6273	10	we	-PRON-	PRP
cord-006229-7yoilsho	6273	11	used	use	VBD
cord-006229-7yoilsho	6273	12	the	the	DT
cord-006229-7yoilsho	6273	13	CKD	CKD	NNP
cord-006229-7yoilsho	6273	14	-	-	HYPH
cord-006229-7yoilsho	6273	15	EPIcr	EPIcr	NNP
cord-006229-7yoilsho	6273	16	equation	equation	NN
cord-006229-7yoilsho	6273	17	.	.	.
cord-006229-7yoilsho	6274	1	Predictor	predictor	NN
cord-006229-7yoilsho	6274	2	analysis	analysis	NN
cord-006229-7yoilsho	6274	3	was	be	VBD
cord-006229-7yoilsho	6274	4	conducted	conduct	VBN
cord-006229-7yoilsho	6274	5	via	via	IN
cord-006229-7yoilsho	6274	6	logistic	logistic	JJ
cord-006229-7yoilsho	6274	7	regression	regression	NN
cord-006229-7yoilsho	6274	8	.	.	.
cord-006229-7yoilsho	6275	1	Results	result	NNS
cord-006229-7yoilsho	6275	2	:	:	:
cord-006229-7yoilsho	6276	1	Figure	figure	NN
cord-006229-7yoilsho	6276	2	1	1	CD
cord-006229-7yoilsho	6276	3	illustrates	illustrate	VBZ
cord-006229-7yoilsho	6276	4	the	the	DT
cord-006229-7yoilsho	6276	5	percentage	percentage	NN
cord-006229-7yoilsho	6276	6	of	of	IN
cord-006229-7yoilsho	6276	7	drug	drug	NN
cord-006229-7yoilsho	6276	8	use	use	NN
cord-006229-7yoilsho	6276	9	for	for	IN
cord-006229-7yoilsho	6276	10	the	the	DT
cord-006229-7yoilsho	6276	11	three	three	CD
cord-006229-7yoilsho	6276	12	NOACs	noac	NNS
cord-006229-7yoilsho	6276	13	and	and	CC
cord-006229-7yoilsho	6276	14	phenprocoumon	phenprocoumon	NNP
cord-006229-7yoilsho	6276	15	,	,	,
cord-006229-7yoilsho	6276	16	the	the	DT
cord-006229-7yoilsho	6276	17	most	most	RBS
cord-006229-7yoilsho	6276	18	common	common	JJ
cord-006229-7yoilsho	6276	19	vitamin	vitamin	NN
cord-006229-7yoilsho	6276	20	K	K	NNP
cord-006229-7yoilsho	6276	21	antagonist	antagonist	NN
cord-006229-7yoilsho	6276	22	in	in	IN
cord-006229-7yoilsho	6276	23	Germany	Germany	NNP
cord-006229-7yoilsho	6276	24	,	,	,
cord-006229-7yoilsho	6276	25	over	over	IN
cord-006229-7yoilsho	6276	26	the	the	DT
cord-006229-7yoilsho	6276	27	course	course	NN
cord-006229-7yoilsho	6276	28	of	of	IN
cord-006229-7yoilsho	6276	29	four	four	CD
cord-006229-7yoilsho	6276	30	years	year	NNS
cord-006229-7yoilsho	6276	31	.	.	.
cord-006229-7yoilsho	6277	1	Table	table	NN
cord-006229-7yoilsho	6277	2	1	1	CD
cord-006229-7yoilsho	6277	3	shows	show	VBZ
cord-006229-7yoilsho	6277	4	the	the	DT
cord-006229-7yoilsho	6277	5	characteristics	characteristic	NNS
cord-006229-7yoilsho	6277	6	of	of	IN
cord-006229-7yoilsho	6277	7	patients	patient	NNS
cord-006229-7yoilsho	6277	8	for	for	IN
cord-006229-7yoilsho	6277	9	each	each	DT
cord-006229-7yoilsho	6277	10	oral	oral	JJ
cord-006229-7yoilsho	6277	11	anticoagulant	anticoagulant	JJ
cord-006229-7yoilsho	6277	12	group	group	NN
cord-006229-7yoilsho	6277	13	during	during	IN
cord-006229-7yoilsho	6277	14	the	the	DT
cord-006229-7yoilsho	6277	15	four	four	CD
cord-006229-7yoilsho	6277	16	-	-	HYPH
cord-006229-7yoilsho	6277	17	year	year	NN
cord-006229-7yoilsho	6277	18	follow	follow	NN
cord-006229-7yoilsho	6277	19	-	-	HYPH
cord-006229-7yoilsho	6277	20	up	up	NN
cord-006229-7yoilsho	6277	21	visit	visit	NN
cord-006229-7yoilsho	6277	22	(	(	-LRB-
cord-006229-7yoilsho	6277	23	from	from	IN
cord-006229-7yoilsho	6277	24	January	January	NNP
cord-006229-7yoilsho	6277	25	2014	2014	CD
cord-006229-7yoilsho	6277	26	until	until	IN
cord-006229-7yoilsho	6277	27	April	April	NNP
cord-006229-7yoilsho	6277	28	2015	2015	CD
cord-006229-7yoilsho	6277	29	)	)	-RRB-
cord-006229-7yoilsho	6277	30	.	.	.
cord-006229-7yoilsho	6278	1	The	the	DT
cord-006229-7yoilsho	6278	2	probability	probability	NN
cord-006229-7yoilsho	6278	3	of	of	IN
cord-006229-7yoilsho	6278	4	dabigatran	dabigatran	JJ
cord-006229-7yoilsho	6278	5	use	use	NN
cord-006229-7yoilsho	6278	6	rose	rise	VBD
cord-006229-7yoilsho	6278	7	with	with	IN
cord-006229-7yoilsho	6278	8	increasing	increase	VBG
cord-006229-7yoilsho	6278	9	age	age	NN
cord-006229-7yoilsho	6278	10	(	(	-LRB-
cord-006229-7yoilsho	6278	11	+12	+12	CD
cord-006229-7yoilsho	6278	12	%	%	NN
cord-006229-7yoilsho	6278	13	)	)	-RRB-
cord-006229-7yoilsho	6278	14	,	,	,
cord-006229-7yoilsho	6278	15	and	and	CC
cord-006229-7yoilsho	6278	16	the	the	DT
cord-006229-7yoilsho	6278	17	probability	probability	NN
cord-006229-7yoilsho	6278	18	of	of	IN
cord-006229-7yoilsho	6278	19	phenprocoumon	phenprocoumon	NN
cord-006229-7yoilsho	6278	20	use	use	NN
cord-006229-7yoilsho	6278	21	rose	rise	VBD
cord-006229-7yoilsho	6278	22	in	in	IN
cord-006229-7yoilsho	6278	23	case	case	NN
cord-006229-7yoilsho	6278	24	of	of	IN
cord-006229-7yoilsho	6278	25	eGFR	egfr	NN
cord-006229-7yoilsho	6278	26	<	<	XX
cord-006229-7yoilsho	6278	27	60	60	CD
cord-006229-7yoilsho	6278	28	ml	ml	NN
cord-006229-7yoilsho	6278	29	/	/	SYM
cord-006229-7yoilsho	6278	30	min/1.73	min/1.73	JJ
cord-006229-7yoilsho	6278	31	m	m	CD
cord-006229-7yoilsho	6278	32	2	2	CD
cord-006229-7yoilsho	6278	33	(	(	-LRB-
cord-006229-7yoilsho	6278	34	+54	+54	CD
cord-006229-7yoilsho	6278	35	%	%	NN
cord-006229-7yoilsho	6278	36	)	)	-RRB-
cord-006229-7yoilsho	6278	37	or	or	CC
cord-006229-7yoilsho	6278	38	male	male	JJ
cord-006229-7yoilsho	6278	39	sex	sex	NN
cord-006229-7yoilsho	6278	40	(	(	-LRB-
cord-006229-7yoilsho	6278	41	+82	+82	CD
cord-006229-7yoilsho	6278	42	%	%	NN
cord-006229-7yoilsho	6278	43	)	)	-RRB-
cord-006229-7yoilsho	6278	44	.	.	.
cord-006229-7yoilsho	6279	1	Discussion	discussion	NN
cord-006229-7yoilsho	6279	2	:	:	:
cord-006229-7yoilsho	6280	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	6280	2	data	datum	NNS
cord-006229-7yoilsho	6280	3	show	show	VBP
cord-006229-7yoilsho	6280	4	that	that	IN
cord-006229-7yoilsho	6280	5	also	also	RB
cord-006229-7yoilsho	6280	6	in	in	IN
cord-006229-7yoilsho	6280	7	the	the	DT
cord-006229-7yoilsho	6280	8	elderly	elderly	JJ
cord-006229-7yoilsho	6280	9	NOAC	NOAC	NNP
cord-006229-7yoilsho	6280	10	use	use	NN
cord-006229-7yoilsho	6280	11	increased	increase	VBD
cord-006229-7yoilsho	6280	12	over	over	IN
cord-006229-7yoilsho	6280	13	the	the	DT
cord-006229-7yoilsho	6280	14	past	past	JJ
cord-006229-7yoilsho	6280	15	years	year	NNS
cord-006229-7yoilsho	6280	16	.	.	.
cord-006229-7yoilsho	6281	1	Characteristics	characteristic	NNS
cord-006229-7yoilsho	6281	2	such	such	JJ
cord-006229-7yoilsho	6281	3	as	as	IN
cord-006229-7yoilsho	6281	4	age	age	NN
cord-006229-7yoilsho	6281	5	,	,	,
cord-006229-7yoilsho	6281	6	sex	sex	NN
cord-006229-7yoilsho	6281	7	or	or	CC
cord-006229-7yoilsho	6281	8	kidney	kidney	NN
cord-006229-7yoilsho	6281	9	function	function	NN
cord-006229-7yoilsho	6281	10	had	have	VBD
cord-006229-7yoilsho	6281	11	an	an	DT
cord-006229-7yoilsho	6281	12	impact	impact	NN
cord-006229-7yoilsho	6281	13	on	on	IN
cord-006229-7yoilsho	6281	14	the	the	DT
cord-006229-7yoilsho	6281	15	choice	choice	NN
cord-006229-7yoilsho	6281	16	of	of	IN
cord-006229-7yoilsho	6281	17	oral	oral	JJ
cord-006229-7yoilsho	6281	18	anticoagulation	anticoagulation	NN
cord-006229-7yoilsho	6281	19	.	.	.
cord-006229-7yoilsho	6282	1	Objective	objective	NN
cord-006229-7yoilsho	6282	2	:	:	:
cord-006229-7yoilsho	6283	1	Orthostatic	orthostatic	JJ
cord-006229-7yoilsho	6283	2	hypotension	hypotension	NN
cord-006229-7yoilsho	6283	3	(	(	-LRB-
cord-006229-7yoilsho	6283	4	OH	oh	UH
cord-006229-7yoilsho	6283	5	)	)	-RRB-
cord-006229-7yoilsho	6283	6	is	be	VBZ
cord-006229-7yoilsho	6283	7	an	an	DT
cord-006229-7yoilsho	6283	8	important	important	JJ
cord-006229-7yoilsho	6283	9	factor	factor	NN
cord-006229-7yoilsho	6283	10	in	in	IN
cord-006229-7yoilsho	6283	11	determining	determine	VBG
cord-006229-7yoilsho	6283	12	cardiovascular	cardiovascular	JJ
cord-006229-7yoilsho	6283	13	mortality	mortality	NN
cord-006229-7yoilsho	6283	14	especially	especially	RB
cord-006229-7yoilsho	6283	15	in	in	IN
cord-006229-7yoilsho	6283	16	older	old	JJR
cord-006229-7yoilsho	6283	17	age	age	NN
cord-006229-7yoilsho	6283	18	.	.	.
cord-006229-7yoilsho	6284	1	Different	different	JJ
cord-006229-7yoilsho	6284	2	factors	factor	NNS
cord-006229-7yoilsho	6284	3	were	be	VBD
cord-006229-7yoilsho	6284	4	discussed	discuss	VBN
cord-006229-7yoilsho	6284	5	to	to	TO
cord-006229-7yoilsho	6284	6	influence	influence	VB
cord-006229-7yoilsho	6284	7	OH	OH	NNP
cord-006229-7yoilsho	6284	8	.	.	.
cord-006229-7yoilsho	6285	1	Arterial	arterial	JJ
cord-006229-7yoilsho	6285	2	stiffness	stiffness	NN
cord-006229-7yoilsho	6285	3	,	,	,
cord-006229-7yoilsho	6285	4	medication	medication	NN
cord-006229-7yoilsho	6285	5	and	and	CC
cord-006229-7yoilsho	6285	6	frailty	frailty	NN
cord-006229-7yoilsho	6285	7	were	be	VBD
cord-006229-7yoilsho	6285	8	demonstrated	demonstrate	VBN
cord-006229-7yoilsho	6285	9	as	as	IN
cord-006229-7yoilsho	6285	10	modifying	modify	VBG
cord-006229-7yoilsho	6285	11	factors	factor	NNS
cord-006229-7yoilsho	6285	12	of	of	IN
cord-006229-7yoilsho	6285	13	OH	OH	NNP
cord-006229-7yoilsho	6285	14	.	.	.
cord-006229-7yoilsho	6286	1	The	the	DT
cord-006229-7yoilsho	6286	2	aim	aim	NN
cord-006229-7yoilsho	6286	3	of	of	IN
cord-006229-7yoilsho	6286	4	this	this	DT
cord-006229-7yoilsho	6286	5	study	study	NN
cord-006229-7yoilsho	6286	6	was	be	VBD
cord-006229-7yoilsho	6286	7	to	to	TO
cord-006229-7yoilsho	6286	8	assess	assess	VB
cord-006229-7yoilsho	6286	9	prevalence	prevalence	NN
cord-006229-7yoilsho	6286	10	of	of	IN
cord-006229-7yoilsho	6286	11	and	and	CC
cord-006229-7yoilsho	6286	12	influencing	influence	VBG
cord-006229-7yoilsho	6286	13	factors	factor	NNS
cord-006229-7yoilsho	6286	14	on	on	IN
cord-006229-7yoilsho	6286	15	OH	OH	NNP
cord-006229-7yoilsho	6286	16	in	in	IN
cord-006229-7yoilsho	6286	17	nursing	nursing	NN
cord-006229-7yoilsho	6286	18	home	home	NN
cord-006229-7yoilsho	6286	19	residents	resident	NNS
cord-006229-7yoilsho	6286	20	(	(	-LRB-
cord-006229-7yoilsho	6286	21	NHR	NHR	NNP
cord-006229-7yoilsho	6286	22	)	)	-RRB-
cord-006229-7yoilsho	6286	23	in	in	IN
cord-006229-7yoilsho	6286	24	Germany	Germany	NNP
cord-006229-7yoilsho	6286	25	.	.	.
cord-006229-7yoilsho	6287	1	Methods	method	NNS
cord-006229-7yoilsho	6287	2	:	:	:
cord-006229-7yoilsho	6287	3	Systolic	systolic	JJ
cord-006229-7yoilsho	6287	4	(	(	-LRB-
cord-006229-7yoilsho	6287	5	SBP	SBP	NNP
cord-006229-7yoilsho	6287	6	)	)	-RRB-
cord-006229-7yoilsho	6287	7	and	and	CC
cord-006229-7yoilsho	6287	8	diastolic	diastolic	JJ
cord-006229-7yoilsho	6287	9	(	(	-LRB-
cord-006229-7yoilsho	6287	10	DBP	dbp	NN
cord-006229-7yoilsho	6287	11	)	)	-RRB-
cord-006229-7yoilsho	6287	12	blood	blood	NN
cord-006229-7yoilsho	6287	13	pressure	pressure	NN
cord-006229-7yoilsho	6287	14	as	as	RB
cord-006229-7yoilsho	6287	15	well	well	RB
cord-006229-7yoilsho	6287	16	as	as	IN
cord-006229-7yoilsho	6287	17	pulse	pulse	NN
cord-006229-7yoilsho	6287	18	pressure	pressure	NN
cord-006229-7yoilsho	6287	19	(	(	-LRB-
cord-006229-7yoilsho	6287	20	PP	PP	NNP
cord-006229-7yoilsho	6287	21	)	)	-RRB-
cord-006229-7yoilsho	6287	22	and	and	CC
cord-006229-7yoilsho	6287	23	pulse	pulse	NN
cord-006229-7yoilsho	6287	24	wave	wave	NN
cord-006229-7yoilsho	6287	25	velocity	velocity	NN
cord-006229-7yoilsho	6287	26	(	(	-LRB-
cord-006229-7yoilsho	6287	27	PWV	PWV	NNP
cord-006229-7yoilsho	6287	28	)	)	-RRB-
cord-006229-7yoilsho	6288	1	as	as	IN
cord-006229-7yoilsho	6288	2	markers	marker	NNS
cord-006229-7yoilsho	6288	3	of	of	IN
cord-006229-7yoilsho	6288	4	arterial	arterial	JJ
cord-006229-7yoilsho	6288	5	stiffness	stiffness	NN
cord-006229-7yoilsho	6288	6	were	be	VBD
cord-006229-7yoilsho	6288	7	measured	measure	VBN
cord-006229-7yoilsho	6288	8	in	in	IN
cord-006229-7yoilsho	6288	9	NHR	NHR	NNP
cord-006229-7yoilsho	6288	10	aged	aged	JJ
cord-006229-7yoilsho	6288	11	≥	≥	CD
cord-006229-7yoilsho	6288	12	65	65	CD
cord-006229-7yoilsho	6288	13	years	year	NNS
cord-006229-7yoilsho	6288	14	in	in	IN
cord-006229-7yoilsho	6288	15	12	12	CD
cord-006229-7yoilsho	6288	16	nursing	nursing	NN
cord-006229-7yoilsho	6288	17	homes	home	NNS
cord-006229-7yoilsho	6288	18	in	in	IN
cord-006229-7yoilsho	6288	19	Berlin	Berlin	NNP
cord-006229-7yoilsho	6288	20	,	,	,
cord-006229-7yoilsho	6288	21	Germany	Germany	NNP
cord-006229-7yoilsho	6288	22	.	.	.
cord-006229-7yoilsho	6289	1	Measurements	measurement	NNS
cord-006229-7yoilsho	6289	2	were	be	VBD
cord-006229-7yoilsho	6289	3	first	first	RB
cord-006229-7yoilsho	6289	4	performed	perform	VBN
cord-006229-7yoilsho	6289	5	in	in	IN
cord-006229-7yoilsho	6289	6	the	the	DT
cord-006229-7yoilsho	6289	7	sitting	sit	VBG
cord-006229-7yoilsho	6289	8	position	position	NN
cord-006229-7yoilsho	6289	9	and	and	CC
cord-006229-7yoilsho	6289	10	then	then	RB
cord-006229-7yoilsho	6289	11	repeated	repeat	VBN
cord-006229-7yoilsho	6289	12	after	after	IN
cord-006229-7yoilsho	6289	13	standing	stand	VBG
cord-006229-7yoilsho	6289	14	up	up	RP
cord-006229-7yoilsho	6289	15	.	.	.
cord-006229-7yoilsho	6290	1	OH	OH	NNP
cord-006229-7yoilsho	6290	2	was	be	VBD
cord-006229-7yoilsho	6290	3	defined	define	VBN
cord-006229-7yoilsho	6290	4	as	as	IN
cord-006229-7yoilsho	6290	5	a	a	DT
cord-006229-7yoilsho	6290	6	SBP	SBP	NNP
cord-006229-7yoilsho	6290	7	decrease	decrease	NN
cord-006229-7yoilsho	6290	8	of	of	IN
cord-006229-7yoilsho	6290	9	>	>	$
cord-006229-7yoilsho	6290	10	20	20	CD
cord-006229-7yoilsho	6290	11	mmHg	mmHg	NNS
cord-006229-7yoilsho	6290	12	and/or	and/or	CC
cord-006229-7yoilsho	6291	1	DBP	DBP	NNP
cord-006229-7yoilsho	6291	2	decrease	decrease	NN
cord-006229-7yoilsho	6291	3	of	of	IN
cord-006229-7yoilsho	6291	4	>	>	SYM
cord-006229-7yoilsho	6291	5	10	10	CD
cord-006229-7yoilsho	6291	6	mmHg	mmHg	NNS
cord-006229-7yoilsho	6291	7	within	within	IN
cord-006229-7yoilsho	6291	8	3	3	CD
cord-006229-7yoilsho	6291	9	min	min	NN
cord-006229-7yoilsho	6291	10	after	after	IN
cord-006229-7yoilsho	6291	11	standing	stand	VBG
cord-006229-7yoilsho	6291	12	up	up	RP
cord-006229-7yoilsho	6291	13	.	.	.
cord-006229-7yoilsho	6292	1	Hypertension	hypertension	NN
cord-006229-7yoilsho	6292	2	was	be	VBD
cord-006229-7yoilsho	6292	3	defined	define	VBN
cord-006229-7yoilsho	6292	4	as	as	IN
cord-006229-7yoilsho	6292	5	the	the	DT
cord-006229-7yoilsho	6292	6	presence	presence	NN
cord-006229-7yoilsho	6292	7	of	of	IN
cord-006229-7yoilsho	6292	8	diagnosis	diagnosis	NN
cord-006229-7yoilsho	6292	9	arterial	arterial	JJ
cord-006229-7yoilsho	6292	10	hypertension	hypertension	NN
cord-006229-7yoilsho	6292	11	,	,	,
cord-006229-7yoilsho	6292	12	the	the	DT
cord-006229-7yoilsho	6292	13	prescription	prescription	NN
cord-006229-7yoilsho	6292	14	of	of	IN
cord-006229-7yoilsho	6292	15	at	at	RB
cord-006229-7yoilsho	6292	16	least	least	RBS
cord-006229-7yoilsho	6292	17	one	one	CD
cord-006229-7yoilsho	6292	18	antihypertensive	antihypertensive	JJ
cord-006229-7yoilsho	6292	19	drug	drug	NN
cord-006229-7yoilsho	6292	20	,	,	,
cord-006229-7yoilsho	6292	21	or	or	CC
cord-006229-7yoilsho	6292	22	mean	mean	VB
cord-006229-7yoilsho	6292	23	SBP	SBP	NNP
cord-006229-7yoilsho	6292	24	values	value	NNS
cord-006229-7yoilsho	6293	1	>	>	XX
cord-006229-7yoilsho	6294	1	139	139	CD
cord-006229-7yoilsho	6294	2	mmHg	mmhg	NN
cord-006229-7yoilsho	6295	1	and/or	and/or	CC
cord-006229-7yoilsho	6295	2	mean	mean	VB
cord-006229-7yoilsho	6295	3	DBP	DBP	NNP
cord-006229-7yoilsho	6295	4	>	>	XX
cord-006229-7yoilsho	6296	1	89	89	CD
cord-006229-7yoilsho	6296	2	mmHg	mmHg	NNS
cord-006229-7yoilsho	6296	3	.	.	.
cord-006229-7yoilsho	6297	1	Information	information	NN
cord-006229-7yoilsho	6297	2	about	about	IN
cord-006229-7yoilsho	6297	3	antihypertensive	antihypertensive	JJ
cord-006229-7yoilsho	6297	4	medication	medication	NN
cord-006229-7yoilsho	6297	5	was	be	VBD
cord-006229-7yoilsho	6297	6	received	receive	VBN
cord-006229-7yoilsho	6297	7	from	from	IN
cord-006229-7yoilsho	6297	8	interviews	interview	NNS
cord-006229-7yoilsho	6297	9	and	and	CC
cord-006229-7yoilsho	6297	10	medical	medical	JJ
cord-006229-7yoilsho	6297	11	records	record	NNS
cord-006229-7yoilsho	6297	12	.	.	.
cord-006229-7yoilsho	6298	1	Frailty	frailty	NN
cord-006229-7yoilsho	6298	2	was	be	VBD
cord-006229-7yoilsho	6298	3	determined	determine	VBN
cord-006229-7yoilsho	6298	4	by	by	IN
cord-006229-7yoilsho	6298	5	geriatric	geriatric	JJ
cord-006229-7yoilsho	6298	6	assessments	assessment	NNS
cord-006229-7yoilsho	6298	7	,	,	,
cord-006229-7yoilsho	6298	8	e.g.	e.g.	RB
cord-006229-7yoilsho	6298	9	"	"	``
cord-006229-7yoilsho	6298	10	Timed	time	VBN
cord-006229-7yoilsho	6298	11	Up	up	RP
cord-006229-7yoilsho	6298	12	and	and	CC
cord-006229-7yoilsho	6298	13	Go	go	VB
cord-006229-7yoilsho	6298	14	Test	test	NN
cord-006229-7yoilsho	6298	15	"	"	''
cord-006229-7yoilsho	6298	16	(	(	-LRB-
cord-006229-7yoilsho	6298	17	TUG	tug	NN
cord-006229-7yoilsho	6298	18	)	)	-RRB-
cord-006229-7yoilsho	6298	19	or	or	CC
cord-006229-7yoilsho	6298	20	Barthel	Barthel	NNP
cord-006229-7yoilsho	6298	21	Scale	Scale	NNP
cord-006229-7yoilsho	6298	22	.	.	.
cord-006229-7yoilsho	6299	1	Results	result	NNS
cord-006229-7yoilsho	6299	2	:	:	:
cord-006229-7yoilsho	6300	1	OH	oh	UH
cord-006229-7yoilsho	6300	2	testing	testing	NN
cord-006229-7yoilsho	6300	3	could	could	MD
cord-006229-7yoilsho	6300	4	be	be	VB
cord-006229-7yoilsho	6300	5	performed	perform	VBN
cord-006229-7yoilsho	6300	6	with	with	IN
cord-006229-7yoilsho	6300	7	96	96	CD
cord-006229-7yoilsho	6300	8	NHR	NHR	NNP
cord-006229-7yoilsho	6300	9	(	(	-LRB-
cord-006229-7yoilsho	6300	10	mean	mean	JJ
cord-006229-7yoilsho	6300	11	age	age	NN
cord-006229-7yoilsho	6300	12	=	=	SYM
cord-006229-7yoilsho	6300	13	84.5	84.5	CD
cord-006229-7yoilsho	6300	14	±	±	NNP
cord-006229-7yoilsho	6300	15	7.3	7.3	CD
cord-006229-7yoilsho	6300	16	years	year	NNS
cord-006229-7yoilsho	6300	17	)	)	-RRB-
cord-006229-7yoilsho	6300	18	.	.	.
cord-006229-7yoilsho	6301	1	In	in	IN
cord-006229-7yoilsho	6301	2	total	total	JJ
cord-006229-7yoilsho	6301	3	,	,	,
cord-006229-7yoilsho	6301	4	15	15	CD
cord-006229-7yoilsho	6301	5	subjects	subject	NNS
cord-006229-7yoilsho	6301	6	(	(	-LRB-
cord-006229-7yoilsho	6301	7	15.6	15.6	CD
cord-006229-7yoilsho	6301	8	%	%	NN
cord-006229-7yoilsho	6301	9	)	)	-RRB-
cord-006229-7yoilsho	6301	10	had	have	VBD
cord-006229-7yoilsho	6301	11	OH	oh	UH
cord-006229-7yoilsho	6301	12	.	.	.
cord-006229-7yoilsho	6302	1	The	the	DT
cord-006229-7yoilsho	6302	2	mean	mean	JJ
cord-006229-7yoilsho	6302	3	change	change	NN
cord-006229-7yoilsho	6302	4	in	in	IN
cord-006229-7yoilsho	6302	5	SBP	SBP	NNP
cord-006229-7yoilsho	6302	6	from	from	IN
cord-006229-7yoilsho	6302	7	sitting	sit	VBG
cord-006229-7yoilsho	6302	8	to	to	IN
cord-006229-7yoilsho	6302	9	standing	standing	NN
cord-006229-7yoilsho	6302	10	was	be	VBD
cord-006229-7yoilsho	6302	11	19.2	19.2	CD
cord-006229-7yoilsho	6302	12	±	±	NNP
cord-006229-7yoilsho	6302	13	15	15	CD
cord-006229-7yoilsho	6302	14	mmHg	mmHg	NNS
cord-006229-7yoilsho	6302	15	(	(	-LRB-
cord-006229-7yoilsho	6302	16	range	range	VB
cord-006229-7yoilsho	6302	17	+8.5	+8.5	ADD
cord-006229-7yoilsho	6302	18	to	to	IN
cord-006229-7yoilsho	6302	19	-52.5	-52.5	NNP
cord-006229-7yoilsho	6302	20	mmHg	mmHg	NNP
cord-006229-7yoilsho	6302	21	)	)	-RRB-
cord-006229-7yoilsho	6302	22	in	in	IN
cord-006229-7yoilsho	6302	23	patients	patient	NNS
cord-006229-7yoilsho	6302	24	with	with	IN
cord-006229-7yoilsho	6302	25	OH	OH	NNP
cord-006229-7yoilsho	6302	26	and	and	CC
cord-006229-7yoilsho	6302	27	1.5	1.5	CD
cord-006229-7yoilsho	6302	28	±10.9	±10.9	CD
cord-006229-7yoilsho	6302	29	mmHg	mmHg	NNS
cord-006229-7yoilsho	6302	30	(	(	-LRB-
cord-006229-7yoilsho	6302	31	range	range	VBP
cord-006229-7yoilsho	6302	32	+44.5	+44.5	XX
cord-006229-7yoilsho	6302	33	to	to	IN
cord-006229-7yoilsho	6302	34	-17	-17	CD
cord-006229-7yoilsho	6302	35	mmHg	mmHg	NNS
cord-006229-7yoilsho	6302	36	)	)	-RRB-
cord-006229-7yoilsho	6302	37	in	in	IN
cord-006229-7yoilsho	6302	38	patients	patient	NNS
cord-006229-7yoilsho	6302	39	without	without	IN
cord-006229-7yoilsho	6302	40	OH	oh	UH
cord-006229-7yoilsho	6302	41	.	.	.
cord-006229-7yoilsho	6303	1	Mean	mean	JJ
cord-006229-7yoilsho	6303	2	SBP	SBP	NNP
cord-006229-7yoilsho	6303	3	was	be	VBD
cord-006229-7yoilsho	6303	4	significantly	significantly	RB
cord-006229-7yoilsho	6303	5	higher	high	JJR
cord-006229-7yoilsho	6303	6	(	(	-LRB-
cord-006229-7yoilsho	6303	7	143.6	143.6	CD
cord-006229-7yoilsho	6303	8	±	±	CD
cord-006229-7yoilsho	6303	9	17.1	17.1	CD
cord-006229-7yoilsho	6303	10	mmHg	mmHg	NNPS
cord-006229-7yoilsho	6303	11	)	)	-RRB-
cord-006229-7yoilsho	6303	12	in	in	IN
cord-006229-7yoilsho	6303	13	people	people	NNS
cord-006229-7yoilsho	6303	14	with	with	IN
cord-006229-7yoilsho	6303	15	OH	oh	UH
cord-006229-7yoilsho	6303	16	than	than	IN
cord-006229-7yoilsho	6303	17	in	in	IN
cord-006229-7yoilsho	6303	18	those	those	DT
cord-006229-7yoilsho	6303	19	without	without	IN
cord-006229-7yoilsho	6303	20	(	(	-LRB-
cord-006229-7yoilsho	6303	21	131.5	131.5	CD
cord-006229-7yoilsho	6303	22	±	±	CD
cord-006229-7yoilsho	6303	23	20.1mmHg	20.1mmhg	CD
cord-006229-7yoilsho	6303	24	)	)	-RRB-
cord-006229-7yoilsho	6303	25	.	.	.
cord-006229-7yoilsho	6304	1	All	all	DT
cord-006229-7yoilsho	6304	2	of	of	IN
cord-006229-7yoilsho	6304	3	the	the	DT
cord-006229-7yoilsho	6304	4	NHR	NHR	NNP
cord-006229-7yoilsho	6304	5	with	with	IN
cord-006229-7yoilsho	6304	6	OH	OH	NNP
cord-006229-7yoilsho	6304	7	were	be	VBD
cord-006229-7yoilsho	6304	8	hypertensive	hypertensive	JJ
cord-006229-7yoilsho	6304	9	compared	compare	VBN
cord-006229-7yoilsho	6304	10	to	to	IN
cord-006229-7yoilsho	6304	11	89	89	CD
cord-006229-7yoilsho	6304	12	%	%	NN
cord-006229-7yoilsho	6304	13	of	of	IN
cord-006229-7yoilsho	6304	14	the	the	DT
cord-006229-7yoilsho	6304	15	NHR	NHR	NNP
cord-006229-7yoilsho	6304	16	without	without	IN
cord-006229-7yoilsho	6304	17	OH	OH	NNP
cord-006229-7yoilsho	6304	18	.	.	.
cord-006229-7yoilsho	6305	1	Sex	sex	NN
cord-006229-7yoilsho	6305	2	,	,	,
cord-006229-7yoilsho	6305	3	mean	mean	VB
cord-006229-7yoilsho	6305	4	age	age	NN
cord-006229-7yoilsho	6305	5	,	,	,
cord-006229-7yoilsho	6305	6	PWV	PWV	NNP
cord-006229-7yoilsho	6305	7	and	and	CC
cord-006229-7yoilsho	6305	8	PP	PP	NNP
cord-006229-7yoilsho	6305	9	was	be	VBD
cord-006229-7yoilsho	6305	10	not	not	RB
cord-006229-7yoilsho	6305	11	significantly	significantly	RB
cord-006229-7yoilsho	6305	12	different	different	JJ
cord-006229-7yoilsho	6305	13	between	between	IN
cord-006229-7yoilsho	6305	14	individuals	individual	NNS
cord-006229-7yoilsho	6305	15	with	with	IN
cord-006229-7yoilsho	6305	16	or	or	CC
cord-006229-7yoilsho	6305	17	without	without	IN
cord-006229-7yoilsho	6305	18	OH	oh	UH
cord-006229-7yoilsho	6305	19	(	(	-LRB-
cord-006229-7yoilsho	6305	20	p>0.05	p>0.05	NNP
cord-006229-7yoilsho	6305	21	)	)	-RRB-
cord-006229-7yoilsho	6305	22	.	.	.
cord-006229-7yoilsho	6306	1	Medication	medication	NN
cord-006229-7yoilsho	6306	2	data	datum	NNS
cord-006229-7yoilsho	6306	3	was	be	VBD
cord-006229-7yoilsho	6306	4	available	available	JJ
cord-006229-7yoilsho	6306	5	for	for	IN
cord-006229-7yoilsho	6306	6	89	89	CD
cord-006229-7yoilsho	6306	7	patients	patient	NNS
cord-006229-7yoilsho	6306	8	.	.	.
cord-006229-7yoilsho	6307	1	All	all	DT
cord-006229-7yoilsho	6307	2	individuals	individual	NNS
cord-006229-7yoilsho	6307	3	with	with	IN
cord-006229-7yoilsho	6307	4	OH	OH	NNP
cord-006229-7yoilsho	6307	5	and	and	CC
cord-006229-7yoilsho	6307	6	60	60	CD
cord-006229-7yoilsho	6307	7	NHR	NHR	NNP
cord-006229-7yoilsho	6307	8	without	without	IN
cord-006229-7yoilsho	6307	9	OH	OH	NNP
cord-006229-7yoilsho	6307	10	(	(	-LRB-
cord-006229-7yoilsho	6307	11	80	80	CD
cord-006229-7yoilsho	6307	12	%	%	NN
cord-006229-7yoilsho	6307	13	)	)	-RRB-
cord-006229-7yoilsho	6307	14	had	have	VBD
cord-006229-7yoilsho	6307	15	antihypertensive	antihypertensive	JJ
cord-006229-7yoilsho	6307	16	medication	medication	NN
cord-006229-7yoilsho	6307	17	.	.	.
cord-006229-7yoilsho	6308	1	More	More	JJR
cord-006229-7yoilsho	6308	2	than	than	IN
cord-006229-7yoilsho	6308	3	2	2	CD
cord-006229-7yoilsho	6308	4	different	different	JJ
cord-006229-7yoilsho	6308	5	antihypertensive	antihypertensive	JJ
cord-006229-7yoilsho	6308	6	drugs	drug	NNS
cord-006229-7yoilsho	6308	7	were	be	VBD
cord-006229-7yoilsho	6308	8	present	present	JJ
cord-006229-7yoilsho	6308	9	in	in	IN
cord-006229-7yoilsho	6308	10	11	11	CD
cord-006229-7yoilsho	6308	11	patients	patient	NNS
cord-006229-7yoilsho	6308	12	with	with	IN
cord-006229-7yoilsho	6308	13	OH	OH	NNP
cord-006229-7yoilsho	6308	14	(	(	-LRB-
cord-006229-7yoilsho	6308	15	78.5	78.5	CD
cord-006229-7yoilsho	6308	16	%	%	NN
cord-006229-7yoilsho	6308	17	)	)	-RRB-
cord-006229-7yoilsho	6308	18	and	and	CC
cord-006229-7yoilsho	6308	19	in	in	IN
cord-006229-7yoilsho	6308	20	43	43	CD
cord-006229-7yoilsho	6308	21	patients	patient	NNS
cord-006229-7yoilsho	6308	22	without	without	IN
cord-006229-7yoilsho	6308	23	OH	OH	NNP
cord-006229-7yoilsho	6308	24	(	(	-LRB-
cord-006229-7yoilsho	6308	25	57.3	57.3	CD
cord-006229-7yoilsho	6308	26	%	%	NN
cord-006229-7yoilsho	6308	27	)	)	-RRB-
cord-006229-7yoilsho	6308	28	.	.	.
cord-006229-7yoilsho	6309	1	The	the	DT
cord-006229-7yoilsho	6309	2	intake	intake	NN
cord-006229-7yoilsho	6309	3	of	of	IN
cord-006229-7yoilsho	6309	4	beta	beta	NN
cord-006229-7yoilsho	6309	5	-	-	HYPH
cord-006229-7yoilsho	6309	6	blockers	blocker	NNS
cord-006229-7yoilsho	6309	7	had	have	VBD
cord-006229-7yoilsho	6309	8	no	no	DT
cord-006229-7yoilsho	6309	9	impact	impact	NN
cord-006229-7yoilsho	6309	10	on	on	IN
cord-006229-7yoilsho	6309	11	OH	OH	NNP
cord-006229-7yoilsho	6309	12	development	development	NN
cord-006229-7yoilsho	6309	13	.	.	.
cord-006229-7yoilsho	6310	1	Geriatric	geriatric	JJ
cord-006229-7yoilsho	6310	2	assessments	assessment	NNS
cord-006229-7yoilsho	6310	3	did	do	VBD
cord-006229-7yoilsho	6310	4	not	not	RB
cord-006229-7yoilsho	6310	5	differ	differ	VB
cord-006229-7yoilsho	6310	6	significantly	significantly	RB
cord-006229-7yoilsho	6310	7	between	between	IN
cord-006229-7yoilsho	6310	8	the	the	DT
cord-006229-7yoilsho	6310	9	OH	OH	NNP
cord-006229-7yoilsho	6310	10	group	group	NN
cord-006229-7yoilsho	6310	11	and	and	CC
cord-006229-7yoilsho	6310	12	the	the	DT
cord-006229-7yoilsho	6310	13	non	non	JJ
cord-006229-7yoilsho	6310	14	-	-	JJ
cord-006229-7yoilsho	6310	15	OH	oh	JJ
cord-006229-7yoilsho	6310	16	group	group	NN
cord-006229-7yoilsho	6310	17	.	.	.
cord-006229-7yoilsho	6311	1	More	More	JJR
cord-006229-7yoilsho	6311	2	than	than	IN
cord-006229-7yoilsho	6311	3	75	75	CD
cord-006229-7yoilsho	6311	4	%	%	NN
cord-006229-7yoilsho	6311	5	of	of	IN
cord-006229-7yoilsho	6311	6	patients	patient	NNS
cord-006229-7yoilsho	6311	7	in	in	IN
cord-006229-7yoilsho	6311	8	both	both	DT
cord-006229-7yoilsho	6311	9	groups	group	NNS
cord-006229-7yoilsho	6311	10	reached	reach	VBD
cord-006229-7yoilsho	6311	11	80	80	CD
cord-006229-7yoilsho	6311	12	points	point	NNS
cord-006229-7yoilsho	6311	13	as	as	IN
cord-006229-7yoilsho	6311	14	maximum	maximum	NN
cord-006229-7yoilsho	6311	15	in	in	IN
cord-006229-7yoilsho	6311	16	Barthel	Barthel	NNP
cord-006229-7yoilsho	6311	17	Scale	Scale	NNP
cord-006229-7yoilsho	6311	18	defining	define	VBG
cord-006229-7yoilsho	6311	19	a	a	DT
cord-006229-7yoilsho	6311	20	need	need	NN
cord-006229-7yoilsho	6311	21	for	for	IN
cord-006229-7yoilsho	6311	22	assistance	assistance	NN
cord-006229-7yoilsho	6311	23	and	and	CC
cord-006229-7yoilsho	6311	24	TUG	tug	NN
cord-006229-7yoilsho	6311	25	analyses	analysis	NNS
cord-006229-7yoilsho	6311	26	demonstrated	demonstrate	VBD
cord-006229-7yoilsho	6311	27	that	that	IN
cord-006229-7yoilsho	6311	28	around	around	IN
cord-006229-7yoilsho	6311	29	50	50	CD
cord-006229-7yoilsho	6311	30	%	%	NN
cord-006229-7yoilsho	6311	31	of	of	IN
cord-006229-7yoilsho	6311	32	patients	patient	NNS
cord-006229-7yoilsho	6311	33	with	with	IN
cord-006229-7yoilsho	6311	34	OH	oh	UH
cord-006229-7yoilsho	6311	35	as	as	RB
cord-006229-7yoilsho	6311	36	well	well	RB
cord-006229-7yoilsho	6311	37	as	as	IN
cord-006229-7yoilsho	6311	38	patients	patient	NNS
cord-006229-7yoilsho	6311	39	without	without	IN
cord-006229-7yoilsho	6311	40	OH	OH	NNP
cord-006229-7yoilsho	6311	41	needed	need	VBD
cord-006229-7yoilsho	6311	42	more	more	JJR
cord-006229-7yoilsho	6311	43	than	than	IN
cord-006229-7yoilsho	6311	44	19	19	CD
cord-006229-7yoilsho	6311	45	sec	sec	NNS
cord-006229-7yoilsho	6311	46	showing	show	VBG
cord-006229-7yoilsho	6311	47	a	a	DT
cord-006229-7yoilsho	6311	48	motor	motor	NN
cord-006229-7yoilsho	6311	49	slowing	slow	VBG
cord-006229-7yoilsho	6311	50	.	.	.
cord-006229-7yoilsho	6312	1	Conclusion	conclusion	NN
cord-006229-7yoilsho	6312	2	:	:	:
cord-006229-7yoilsho	6313	1	We	-PRON-	PRP
cord-006229-7yoilsho	6313	2	found	find	VBD
cord-006229-7yoilsho	6313	3	a	a	DT
cord-006229-7yoilsho	6313	4	relatively	relatively	RB
cord-006229-7yoilsho	6313	5	low	low	JJ
cord-006229-7yoilsho	6313	6	prevalence	prevalence	NN
cord-006229-7yoilsho	6313	7	of	of	IN
cord-006229-7yoilsho	6313	8	OH	OH	NNP
cord-006229-7yoilsho	6313	9	in	in	IN
cord-006229-7yoilsho	6313	10	our	-PRON-	PRP$
cord-006229-7yoilsho	6313	11	very	very	RB
cord-006229-7yoilsho	6313	12	old	old	JJ
cord-006229-7yoilsho	6313	13	patient	patient	JJ
cord-006229-7yoilsho	6313	14	cohort	cohort	NN
cord-006229-7yoilsho	6313	15	and	and	CC
cord-006229-7yoilsho	6313	16	the	the	DT
cord-006229-7yoilsho	6313	17	overall	overall	JJ
cord-006229-7yoilsho	6313	18	BP	BP	NNP
cord-006229-7yoilsho	6313	19	control	control	NN
cord-006229-7yoilsho	6313	20	was	be	VBD
cord-006229-7yoilsho	6313	21	good	good	JJ
cord-006229-7yoilsho	6313	22	.	.	.
cord-006229-7yoilsho	6314	1	Similar	similar	JJ
cord-006229-7yoilsho	6314	2	to	to	IN
cord-006229-7yoilsho	6314	3	earlier	early	JJR
cord-006229-7yoilsho	6314	4	publications	publication	NNS
cord-006229-7yoilsho	6314	5	mean	mean	VBP
cord-006229-7yoilsho	6314	6	SBP	SBP	NNP
cord-006229-7yoilsho	6314	7	was	be	VBD
cord-006229-7yoilsho	6314	8	significantly	significantly	RB
cord-006229-7yoilsho	6314	9	higher	high	JJR
cord-006229-7yoilsho	6314	10	in	in	IN
cord-006229-7yoilsho	6314	11	NHR	NHR	NNP
cord-006229-7yoilsho	6314	12	with	with	IN
cord-006229-7yoilsho	6314	13	OH	OH	NNP
cord-006229-7yoilsho	6314	14	.	.	.
cord-006229-7yoilsho	6315	1	All	all	DT
cord-006229-7yoilsho	6315	2	of	of	IN
cord-006229-7yoilsho	6315	3	the	the	DT
cord-006229-7yoilsho	6315	4	other	other	JJ
cord-006229-7yoilsho	6315	5	investigated	investigate	VBN
cord-006229-7yoilsho	6315	6	factors	factor	NNS
cord-006229-7yoilsho	6315	7	were	be	VBD
cord-006229-7yoilsho	6315	8	not	not	RB
cord-006229-7yoilsho	6315	9	associated	associate	VBN
cord-006229-7yoilsho	6315	10	with	with	IN
cord-006229-7yoilsho	6315	11	the	the	DT
cord-006229-7yoilsho	6315	12	occurrence	occurrence	NN
cord-006229-7yoilsho	6315	13	of	of	IN
cord-006229-7yoilsho	6315	14	OH	OH	NNP
cord-006229-7yoilsho	6315	15	.	.	.
cord-006229-7yoilsho	6316	1	The	the	DT
cord-006229-7yoilsho	6316	2	small	small	JJ
cord-006229-7yoilsho	6316	3	cohort	cohort	NN
cord-006229-7yoilsho	6316	4	size	size	NN
cord-006229-7yoilsho	6316	5	might	may	MD
cord-006229-7yoilsho	6316	6	have	have	VB
cord-006229-7yoilsho	6316	7	limited	limit	VBN
cord-006229-7yoilsho	6316	8	the	the	DT
cord-006229-7yoilsho	6316	9	detection	detection	NN
cord-006229-7yoilsho	6316	10	of	of	IN
cord-006229-7yoilsho	6316	11	cardiovascular	cardiovascular	JJ
cord-006229-7yoilsho	6316	12	,	,	,
cord-006229-7yoilsho	6316	13	epidemiological	epidemiological	JJ
cord-006229-7yoilsho	6316	14	or	or	CC
cord-006229-7yoilsho	6316	15	geriatric	geriatric	JJ
cord-006229-7yoilsho	6316	16	associations	association	NNS
cord-006229-7yoilsho	6316	17	.	.	.
cord-006229-7yoilsho	6317	1	In	in	IN
cord-006229-7yoilsho	6317	2	addition	addition	NN
cord-006229-7yoilsho	6317	3	,	,	,
cord-006229-7yoilsho	6317	4	important	important	JJ
cord-006229-7yoilsho	6317	5	confounding	confounding	JJ
cord-006229-7yoilsho	6317	6	factors	factor	NNS
cord-006229-7yoilsho	6317	7	such	such	JJ
cord-006229-7yoilsho	6317	8	as	as	IN
cord-006229-7yoilsho	6317	9	the	the	DT
cord-006229-7yoilsho	6317	10	inability	inability	NN
cord-006229-7yoilsho	6317	11	to	to	TO
cord-006229-7yoilsho	6317	12	stand	stand	VB
cord-006229-7yoilsho	6317	13	of	of	IN
cord-006229-7yoilsho	6317	14	some	some	DT
cord-006229-7yoilsho	6317	15	NHR	NHR	NNP
cord-006229-7yoilsho	6317	16	and	and	CC
cord-006229-7yoilsho	6317	17	the	the	DT
cord-006229-7yoilsho	6317	18	lack	lack	NN
cord-006229-7yoilsho	6317	19	of	of	IN
cord-006229-7yoilsho	6317	20	standardized	standardized	JJ
cord-006229-7yoilsho	6317	21	fraility	fraility	NN
cord-006229-7yoilsho	6317	22	assessments	assessment	NNS
cord-006229-7yoilsho	6317	23	must	must	MD
cord-006229-7yoilsho	6317	24	be	be	VB
cord-006229-7yoilsho	6317	25	addressed	address	VBN
cord-006229-7yoilsho	6317	26	.	.	.
cord-006229-7yoilsho	6318	1	Impact	impact	NN
cord-006229-7yoilsho	6318	2	of	of	IN
cord-006229-7yoilsho	6318	3	reticulated	reticulated	JJ
cord-006229-7yoilsho	6318	4	platelets	platelet	NNS
cord-006229-7yoilsho	6318	5	on	on	IN
cord-006229-7yoilsho	6318	6	the	the	DT
cord-006229-7yoilsho	6318	7	initial	initial	JJ
cord-006229-7yoilsho	6318	8	antiplatelet	antiplatelet	NN
cord-006229-7yoilsho	6318	9	response	response	NN
cord-006229-7yoilsho	6318	10	to	to	IN
cord-006229-7yoilsho	6318	11	thienopyridine	thienopyridine	NNP
cord-006229-7yoilsho	6318	12	loading	load	VBG
cord-006229-7yoilsho	6318	13	in	in	IN
cord-006229-7yoilsho	6318	14	patients	patient	NNS
cord-006229-7yoilsho	6318	15	undergoing	undergo	VBG
cord-006229-7yoilsho	6318	16	elective	elective	JJ
cord-006229-7yoilsho	6318	17	coronary	coronary	JJ
cord-006229-7yoilsho	6318	18	intervention	intervention	NN
cord-006229-7yoilsho	6318	19	C.	C.	NNP
cord-006229-7yoilsho	6318	20	Stratz	Stratz	NNP
cord-006229-7yoilsho	6318	21	1	1	CD
cord-006229-7yoilsho	6318	22	,	,	,
cord-006229-7yoilsho	6318	23	T.	T.	NNP
cord-006229-7yoilsho	6318	24	Nuehrenberg	Nuehrenberg	NNP
cord-006229-7yoilsho	6318	25	are	be	VBP
cord-006229-7yoilsho	6318	26	known	know	VBN
cord-006229-7yoilsho	6318	27	to	to	TO
cord-006229-7yoilsho	6318	28	be	be	VB
cord-006229-7yoilsho	6318	29	involved	involve	VBN
cord-006229-7yoilsho	6318	30	in	in	IN
cord-006229-7yoilsho	6318	31	cell	cell	NN
cord-006229-7yoilsho	6318	32	metabolism	metabolism	NN
cord-006229-7yoilsho	6318	33	pathways	pathway	NNS
cord-006229-7yoilsho	6318	34	and	and	CC
cord-006229-7yoilsho	6318	35	therefore	therefore	RB
cord-006229-7yoilsho	6318	36	ccRCC	ccrcc	PRP
cord-006229-7yoilsho	6318	37	is	be	VBZ
cord-006229-7yoilsho	6318	38	supposed	suppose	VBN
cord-006229-7yoilsho	6318	39	to	to	TO
cord-006229-7yoilsho	6318	40	be	be	VB
cord-006229-7yoilsho	6318	41	a	a	DT
cord-006229-7yoilsho	6318	42	metabolic	metabolic	JJ
cord-006229-7yoilsho	6318	43	disease	disease	NN
cord-006229-7yoilsho	6318	44	.	.	.
cord-006229-7yoilsho	6319	1	In	in	IN
cord-006229-7yoilsho	6319	2	order	order	NN
cord-006229-7yoilsho	6319	3	to	to	TO
cord-006229-7yoilsho	6319	4	facilitate	facilitate	VB
cord-006229-7yoilsho	6319	5	a	a	DT
cord-006229-7yoilsho	6319	6	better	well	JJR
cord-006229-7yoilsho	6319	7	understanding	understanding	NN
cord-006229-7yoilsho	6319	8	of	of	IN
cord-006229-7yoilsho	6319	9	cancer	cancer	NN
cord-006229-7yoilsho	6319	10	metabolism	metabolism	NN
cord-006229-7yoilsho	6319	11	and	and	CC
cord-006229-7yoilsho	6319	12	to	to	TO
cord-006229-7yoilsho	6319	13	support	support	VB
cord-006229-7yoilsho	6319	14	tumor	tumor	NN
cord-006229-7yoilsho	6319	15	classification	classification	NN
cord-006229-7yoilsho	6319	16	on	on	IN
cord-006229-7yoilsho	6319	17	the	the	DT
cord-006229-7yoilsho	6319	18	metabolite	metabolite	JJ
cord-006229-7yoilsho	6319	19	level	level	NN
cord-006229-7yoilsho	6319	20	we	-PRON-	PRP
cord-006229-7yoilsho	6319	21	have	have	VBP
cord-006229-7yoilsho	6319	22	developed	develop	VBN
cord-006229-7yoilsho	6319	23	a	a	DT
cord-006229-7yoilsho	6319	24	novel	novel	JJ
cord-006229-7yoilsho	6319	25	analytical	analytical	JJ
cord-006229-7yoilsho	6319	26	approach	approach	NN
cord-006229-7yoilsho	6319	27	for	for	IN
cord-006229-7yoilsho	6319	28	comprehensive	comprehensive	JJ
cord-006229-7yoilsho	6319	29	metabolomic	metabolomic	JJ
cord-006229-7yoilsho	6319	30	profiling	profiling	NN
cord-006229-7yoilsho	6319	31	of	of	IN
cord-006229-7yoilsho	6319	32	small	small	JJ
cord-006229-7yoilsho	6319	33	molecules	molecule	NNS
cord-006229-7yoilsho	6319	34	and	and	CC
cord-006229-7yoilsho	6319	35	lipids	lipid	NNS
cord-006229-7yoilsho	6319	36	in	in	IN
cord-006229-7yoilsho	6319	37	kidney	kidney	NN
cord-006229-7yoilsho	6319	38	tissue	tissue	NN
cord-006229-7yoilsho	6319	39	.	.	.
cord-006229-7yoilsho	6320	1	The	the	DT
cord-006229-7yoilsho	6320	2	method	method	NN
cord-006229-7yoilsho	6320	3	was	be	VBD
cord-006229-7yoilsho	6320	4	established	establish	VBN
cord-006229-7yoilsho	6320	5	and	and	CC
cord-006229-7yoilsho	6320	6	validated	validate	VBN
cord-006229-7yoilsho	6320	7	based	base	VBN
cord-006229-7yoilsho	6320	8	on	on	IN
cord-006229-7yoilsho	6320	9	porcine	porcine	JJ
cord-006229-7yoilsho	6320	10	tissue	tissue	NN
cord-006229-7yoilsho	6320	11	and	and	CC
cord-006229-7yoilsho	6320	12	,	,	,
cord-006229-7yoilsho	6320	13	as	as	IN
cord-006229-7yoilsho	6320	14	proof	proof	NN
cord-006229-7yoilsho	6320	15	of	of	IN
cord-006229-7yoilsho	6320	16	concept	concept	NN
cord-006229-7yoilsho	6320	17	,	,	,
cord-006229-7yoilsho	6320	18	applied	apply	VBD
cord-006229-7yoilsho	6320	19	to	to	IN
cord-006229-7yoilsho	6320	20	a	a	DT
cord-006229-7yoilsho	6320	21	small	small	JJ
cord-006229-7yoilsho	6320	22	cohort	cohort	NN
cord-006229-7yoilsho	6320	23	of	of	IN
cord-006229-7yoilsho	6320	24	human	human	JJ
cord-006229-7yoilsho	6320	25	normal	normal	JJ
cord-006229-7yoilsho	6320	26	and	and	CC
cord-006229-7yoilsho	6320	27	ccRCC	ccrcc	JJ
cord-006229-7yoilsho	6320	28	tissue	tissue	NN
cord-006229-7yoilsho	6320	29	samples	sample	NNS
cord-006229-7yoilsho	6320	30	for	for	IN
cord-006229-7yoilsho	6320	31	molecular	molecular	JJ
cord-006229-7yoilsho	6320	32	tissue	tissue	NN
cord-006229-7yoilsho	6320	33	differentiation	differentiation	NN
cord-006229-7yoilsho	6320	34	.	.	.
cord-006229-7yoilsho	6321	1	Methods	method	NNS
cord-006229-7yoilsho	6321	2	:	:	:
cord-006229-7yoilsho	6321	3	Five	five	CD
cord-006229-7yoilsho	6321	4	fresh	fresh	JJ
cord-006229-7yoilsho	6321	5	frozen	frozen	JJ
cord-006229-7yoilsho	6321	6	ccRCC	ccrcc	NN
cord-006229-7yoilsho	6322	1	samples	sample	NNS
cord-006229-7yoilsho	6322	2	and	and	CC
cord-006229-7yoilsho	6322	3	corresponding	correspond	VBG
cord-006229-7yoilsho	6322	4	normal	normal	JJ
cord-006229-7yoilsho	6322	5	tissue	tissue	NN
cord-006229-7yoilsho	6322	6	were	be	VBD
cord-006229-7yoilsho	6322	7	used	use	VBN
cord-006229-7yoilsho	6322	8	for	for	IN
cord-006229-7yoilsho	6322	9	cancer	cancer	NN
cord-006229-7yoilsho	6322	10	-	-	HYPH
cord-006229-7yoilsho	6322	11	specific	specific	JJ
cord-006229-7yoilsho	6322	12	metabolomic	metabolomic	JJ
cord-006229-7yoilsho	6322	13	profiling	profiling	NN
cord-006229-7yoilsho	6322	14	and	and	CC
cord-006229-7yoilsho	6322	15	were	be	VBD
cord-006229-7yoilsho	6322	16	derived	derive	VBN
cord-006229-7yoilsho	6322	17	from	from	IN
cord-006229-7yoilsho	6322	18	patients	patient	NNS
cord-006229-7yoilsho	6322	19	who	who	WP
cord-006229-7yoilsho	6322	20	underwent	undergo	VBD
cord-006229-7yoilsho	6322	21	partial	partial	JJ
cord-006229-7yoilsho	6322	22	or	or	CC
cord-006229-7yoilsho	6322	23	radical	radical	JJ
cord-006229-7yoilsho	6322	24	nephrectomy	nephrectomy	NN
cord-006229-7yoilsho	6322	25	.	.	.
cord-006229-7yoilsho	6323	1	Metabolites	metabolite	NNS
cord-006229-7yoilsho	6323	2	and	and	CC
cord-006229-7yoilsho	6323	3	lipids	lipid	NNS
cord-006229-7yoilsho	6323	4	were	be	VBD
cord-006229-7yoilsho	6323	5	recovered	recover	VBN
cord-006229-7yoilsho	6323	6	from	from	IN
cord-006229-7yoilsho	6323	7	tissue	tissue	NN
cord-006229-7yoilsho	6323	8	samples	sample	NNS
cord-006229-7yoilsho	6323	9	by	by	IN
cord-006229-7yoilsho	6323	10	a	a	DT
cord-006229-7yoilsho	6323	11	two	two	CD
cord-006229-7yoilsho	6323	12	-	-	HYPH
cord-006229-7yoilsho	6323	13	step	step	NN
cord-006229-7yoilsho	6323	14	extraction	extraction	NN
cord-006229-7yoilsho	6323	15	protocol	protocol	NN
cord-006229-7yoilsho	6323	16	.	.	.
cord-006229-7yoilsho	6324	1	Tissue	tissue	NN
cord-006229-7yoilsho	6324	2	homogenization	homogenization	NN
cord-006229-7yoilsho	6324	3	and	and	CC
cord-006229-7yoilsho	6324	4	extraction	extraction	NN
cord-006229-7yoilsho	6324	5	of	of	IN
cord-006229-7yoilsho	6324	6	polar	polar	JJ
cord-006229-7yoilsho	6324	7	metabolites	metabolite	NNS
cord-006229-7yoilsho	6324	8	was	be	VBD
cord-006229-7yoilsho	6324	9	performed	perform	VBN
cord-006229-7yoilsho	6324	10	in	in	IN
cord-006229-7yoilsho	6324	11	methanol	methanol	NN
cord-006229-7yoilsho	6324	12	/	/	SYM
cord-006229-7yoilsho	6324	13	water	water	NN
cord-006229-7yoilsho	6324	14	(	(	-LRB-
cord-006229-7yoilsho	6324	15	aqueous	aqueous	JJ
cord-006229-7yoilsho	6324	16	extract	extract	NN
cord-006229-7yoilsho	6324	17	)	)	-RRB-
cord-006229-7yoilsho	6324	18	by	by	IN
cord-006229-7yoilsho	6324	19	a	a	DT
cord-006229-7yoilsho	6324	20	beadbeating	beadbeating	JJ
cord-006229-7yoilsho	6324	21	approach	approach	NN
cord-006229-7yoilsho	6324	22	.	.	.
cord-006229-7yoilsho	6325	1	Lipids	lipid	NNS
cord-006229-7yoilsho	6325	2	were	be	VBD
cord-006229-7yoilsho	6325	3	recovered	recover	VBN
cord-006229-7yoilsho	6325	4	by	by	IN
cord-006229-7yoilsho	6325	5	consecutive	consecutive	JJ
cord-006229-7yoilsho	6325	6	extraction	extraction	NN
cord-006229-7yoilsho	6325	7	of	of	IN
cord-006229-7yoilsho	6325	8	the	the	DT
cord-006229-7yoilsho	6325	9	pellet	pellet	NN
cord-006229-7yoilsho	6325	10	with	with	IN
cord-006229-7yoilsho	6325	11	methanol	methanol	NN
cord-006229-7yoilsho	6325	12	/	/	SYM
cord-006229-7yoilsho	6325	13	methyl	methyl	NN
cord-006229-7yoilsho	6325	14	tert	tert	NN
cord-006229-7yoilsho	6325	15	-	-	HYPH
cord-006229-7yoilsho	6325	16	butyl	butyl	NN
cord-006229-7yoilsho	6325	17	ether	ether	NN
cord-006229-7yoilsho	6325	18	(	(	-LRB-
cord-006229-7yoilsho	6325	19	organic	organic	JJ
cord-006229-7yoilsho	6325	20	extract	extract	NN
cord-006229-7yoilsho	6325	21	)	)	-RRB-
cord-006229-7yoilsho	6325	22	.	.	.
cord-006229-7yoilsho	6326	1	Metabolites	metabolite	NNS
cord-006229-7yoilsho	6326	2	in	in	IN
cord-006229-7yoilsho	6326	3	aqueous	aqueous	JJ
cord-006229-7yoilsho	6326	4	extracts	extract	NNS
cord-006229-7yoilsho	6326	5	were	be	VBD
cord-006229-7yoilsho	6326	6	separated	separate	VBN
cord-006229-7yoilsho	6326	7	by	by	IN
cord-006229-7yoilsho	6326	8	hydrophilic	hydrophilic	JJ
cord-006229-7yoilsho	6326	9	liquid	liquid	JJ
cord-006229-7yoilsho	6326	10	interaction	interaction	NN
cord-006229-7yoilsho	6326	11	chromatography	chromatography	NN
cord-006229-7yoilsho	6326	12	whereas	whereas	IN
cord-006229-7yoilsho	6326	13	compounds	compound	NNS
cord-006229-7yoilsho	6326	14	in	in	IN
cord-006229-7yoilsho	6326	15	organic	organic	JJ
cord-006229-7yoilsho	6326	16	extracts	extract	NNS
cord-006229-7yoilsho	6326	17	were	be	VBD
cord-006229-7yoilsho	6326	18	separated	separate	VBN
cord-006229-7yoilsho	6326	19	by	by	IN
cord-006229-7yoilsho	6326	20	reversed	reversed	JJ
cord-006229-7yoilsho	6326	21	phase	phase	NN
cord-006229-7yoilsho	6326	22	chromatography	chromatography	NN
cord-006229-7yoilsho	6326	23	prior	prior	IN
cord-006229-7yoilsho	6326	24	high	high	JJ
cord-006229-7yoilsho	6326	25	resolution	resolution	NN
cord-006229-7yoilsho	6326	26	mass	mass	NN
cord-006229-7yoilsho	6326	27	spectrometry	spectrometry	NN
cord-006229-7yoilsho	6326	28	.	.	.
cord-006229-7yoilsho	6327	1	Results	result	NNS
cord-006229-7yoilsho	6327	2	:	:	:
cord-006229-7yoilsho	6328	1	Reproducibility	reproducibility	NN
cord-006229-7yoilsho	6328	2	of	of	IN
cord-006229-7yoilsho	6328	3	tissue	tissue	NN
cord-006229-7yoilsho	6328	4	extraction	extraction	NN
cord-006229-7yoilsho	6328	5	and	and	CC
cord-006229-7yoilsho	6328	6	metabolite	metabolite	NN
cord-006229-7yoilsho	6328	7	analysis	analysis	NN
cord-006229-7yoilsho	6328	8	was	be	VBD
cord-006229-7yoilsho	6328	9	assessed	assess	VBN
cord-006229-7yoilsho	6328	10	by	by	IN
cord-006229-7yoilsho	6328	11	the	the	DT
cord-006229-7yoilsho	6328	12	analysis	analysis	NN
cord-006229-7yoilsho	6328	13	of	of	IN
cord-006229-7yoilsho	6328	14	multiple	multiple	NN
cord-006229-7yoilsho	6328	15	individually	individually	RB
cord-006229-7yoilsho	6328	16	prepared	prepare	VBN
cord-006229-7yoilsho	6328	17	porcine	porcine	JJ
cord-006229-7yoilsho	6328	18	kidney	kidney	NN
cord-006229-7yoilsho	6328	19	samples	sample	NNS
cord-006229-7yoilsho	6328	20	.	.	.
cord-006229-7yoilsho	6329	1	More	More	JJR
cord-006229-7yoilsho	6329	2	than	than	IN
cord-006229-7yoilsho	6329	3	1000	1000	CD
cord-006229-7yoilsho	6329	4	metabolic	metabolic	JJ
cord-006229-7yoilsho	6329	5	features	feature	NNS
cord-006229-7yoilsho	6329	6	including	include	VBG
cord-006229-7yoilsho	6329	7	amino	amino	NN
cord-006229-7yoilsho	6329	8	acids	acid	NNS
cord-006229-7yoilsho	6329	9	,	,	,
cord-006229-7yoilsho	6329	10	nucleotides	nucleotide	NNS
cord-006229-7yoilsho	6329	11	,	,	,
cord-006229-7yoilsho	6329	12	small	small	JJ
cord-006229-7yoilsho	6329	13	organic	organic	JJ
cord-006229-7yoilsho	6329	14	acids	acid	NNS
cord-006229-7yoilsho	6329	15	,	,	,
cord-006229-7yoilsho	6329	16	phospholipids	phospholipid	NNS
cord-006229-7yoilsho	6329	17	,	,	,
cord-006229-7yoilsho	6329	18	sphingolipids	sphingolipid	NNS
cord-006229-7yoilsho	6329	19	,	,	,
cord-006229-7yoilsho	6329	20	glycerolipids	glycerolipid	NNS
cord-006229-7yoilsho	6329	21	and	and	CC
cord-006229-7yoilsho	6329	22	fatty	fatty	JJ
cord-006229-7yoilsho	6329	23	acids	acid	NNS
cord-006229-7yoilsho	6329	24	could	could	MD
cord-006229-7yoilsho	6329	25	be	be	VB
cord-006229-7yoilsho	6329	26	reproducible	reproducible	JJ
cord-006229-7yoilsho	6329	27	(	(	-LRB-
cord-006229-7yoilsho	6329	28	CV	cv	NN
cord-006229-7yoilsho	6329	29	≤	≤	NNP
cord-006229-7yoilsho	6329	30	30	30	CD
cord-006229-7yoilsho	6329	31	%	%	NN
cord-006229-7yoilsho	6329	32	)	)	-RRB-
cord-006229-7yoilsho	6329	33	analyzed	analyze	VBN
cord-006229-7yoilsho	6329	34	with	with	IN
cord-006229-7yoilsho	6329	35	the	the	DT
cord-006229-7yoilsho	6329	36	novel	novel	JJ
cord-006229-7yoilsho	6329	37	non	non	JJ
cord-006229-7yoilsho	6329	38	-	-	JJ
cord-006229-7yoilsho	6329	39	targeted	targeted	JJ
cord-006229-7yoilsho	6329	40	metabolomics	metabolomic	NNS
cord-006229-7yoilsho	6329	41	approach	approach	NN
cord-006229-7yoilsho	6329	42	.	.	.
cord-006229-7yoilsho	6330	1	The	the	DT
cord-006229-7yoilsho	6330	2	validated	validate	VBN
cord-006229-7yoilsho	6330	3	protocol	protocol	NN
cord-006229-7yoilsho	6330	4	was	be	VBD
cord-006229-7yoilsho	6330	5	applied	apply	VBN
cord-006229-7yoilsho	6330	6	for	for	IN
cord-006229-7yoilsho	6330	7	metabolomic	metabolomic	JJ
cord-006229-7yoilsho	6330	8	profiling	profiling	NN
cord-006229-7yoilsho	6330	9	of	of	IN
cord-006229-7yoilsho	6330	10	kidney	kidney	NN
cord-006229-7yoilsho	6330	11	tissue	tissue	NN
cord-006229-7yoilsho	6330	12	derived	derive	VBN
cord-006229-7yoilsho	6330	13	from	from	IN
cord-006229-7yoilsho	6330	14	ccRCC	ccrcc	NN
cord-006229-7yoilsho	6330	15	patients	patient	NNS
cord-006229-7yoilsho	6330	16	.	.	.
cord-006229-7yoilsho	6331	1	Based	base	VBN
cord-006229-7yoilsho	6331	2	on	on	IN
cord-006229-7yoilsho	6331	3	unsupervised	unsupervised	JJ
cord-006229-7yoilsho	6331	4	multivariate	multivariate	JJ
cord-006229-7yoilsho	6331	5	statistics	statistic	NNS
cord-006229-7yoilsho	6331	6	,	,	,
cord-006229-7yoilsho	6331	7	a	a	DT
cord-006229-7yoilsho	6331	8	clear	clear	JJ
cord-006229-7yoilsho	6331	9	differentiation	differentiation	NN
cord-006229-7yoilsho	6331	10	between	between	IN
cord-006229-7yoilsho	6331	11	cancerous	cancerous	JJ
cord-006229-7yoilsho	6331	12	and	and	CC
cord-006229-7yoilsho	6331	13	normal	normal	JJ
cord-006229-7yoilsho	6331	14	tissue	tissue	NN
cord-006229-7yoilsho	6331	15	for	for	IN
cord-006229-7yoilsho	6331	16	the	the	DT
cord-006229-7yoilsho	6331	17	small	small	JJ
cord-006229-7yoilsho	6331	18	metabolites	metabolite	NNS
cord-006229-7yoilsho	6331	19	profile	profile	VBP
cord-006229-7yoilsho	6331	20	as	as	RB
cord-006229-7yoilsho	6331	21	well	well	RB
cord-006229-7yoilsho	6331	22	as	as	IN
cord-006229-7yoilsho	6331	23	for	for	IN
cord-006229-7yoilsho	6331	24	the	the	DT
cord-006229-7yoilsho	6331	25	lipid	lipid	NN
cord-006229-7yoilsho	6331	26	profile	profile	NN
cord-006229-7yoilsho	6331	27	could	could	MD
cord-006229-7yoilsho	6331	28	be	be	VB
cord-006229-7yoilsho	6331	29	observed	observe	VBN
cord-006229-7yoilsho	6331	30	.	.	.
cord-006229-7yoilsho	6332	1	A	a	DT
cord-006229-7yoilsho	6332	2	first	first	JJ
cord-006229-7yoilsho	6332	3	subset	subset	NN
cord-006229-7yoilsho	6332	4	of	of	IN
cord-006229-7yoilsho	6332	5	differentially	differentially	RB
cord-006229-7yoilsho	6332	6	regulated	regulate	VBN
cord-006229-7yoilsho	6332	7	metabolites	metabolite	NNS
cord-006229-7yoilsho	6332	8	responsible	responsible	JJ
cord-006229-7yoilsho	6332	9	for	for	IN
cord-006229-7yoilsho	6332	10	tissue	tissue	NN
cord-006229-7yoilsho	6332	11	differentiation	differentiation	NN
cord-006229-7yoilsho	6332	12	could	could	MD
cord-006229-7yoilsho	6332	13	be	be	VB
cord-006229-7yoilsho	6332	14	tentatively	tentatively	RB
cord-006229-7yoilsho	6332	15	identified	identify	VBN
cord-006229-7yoilsho	6332	16	.	.	.
cord-006229-7yoilsho	6333	1	Conclusion	conclusion	NN
cord-006229-7yoilsho	6333	2	:	:	:
cord-006229-7yoilsho	6333	3	Metabolomic	Metabolomic	NNP
cord-006229-7yoilsho	6333	4	profiling	profiling	NN
cord-006229-7yoilsho	6333	5	of	of	IN
cord-006229-7yoilsho	6333	6	kidney	kidney	NN
cord-006229-7yoilsho	6333	7	tissue	tissue	NN
cord-006229-7yoilsho	6333	8	extracts	extract	NNS
cord-006229-7yoilsho	6333	9	enables	enable	VBZ
cord-006229-7yoilsho	6333	10	differentiation	differentiation	NN
cord-006229-7yoilsho	6333	11	between	between	IN
cord-006229-7yoilsho	6333	12	ccRCC	ccrcc	NN
cord-006229-7yoilsho	6333	13	and	and	CC
cord-006229-7yoilsho	6333	14	normal	normal	JJ
cord-006229-7yoilsho	6333	15	kidney	kidney	NN
cord-006229-7yoilsho	6333	16	tissue	tissue	NN
cord-006229-7yoilsho	6333	17	samples	sample	NNS
cord-006229-7yoilsho	6333	18	based	base	VBN
cord-006229-7yoilsho	6333	19	on	on	IN
cord-006229-7yoilsho	6333	20	the	the	DT
cord-006229-7yoilsho	6333	21	lipid	lipid	NN
cord-006229-7yoilsho	6333	22	and	and	CC
cord-006229-7yoilsho	6333	23	small	small	JJ
cord-006229-7yoilsho	6333	24	molecule	molecule	NN
cord-006229-7yoilsho	6333	25	metabolomic	metabolomic	NN
cord-006229-7yoilsho	6333	26	profiles	profile	NNS
cord-006229-7yoilsho	6333	27	.	.	.
cord-006229-7yoilsho	6334	1	Further	further	JJ
cord-006229-7yoilsho	6334	2	studies	study	NNS
cord-006229-7yoilsho	6334	3	on	on	IN
cord-006229-7yoilsho	6334	4	larger	large	JJR
cord-006229-7yoilsho	6334	5	and	and	CC
cord-006229-7yoilsho	6334	6	independent	independent	JJ
cord-006229-7yoilsho	6334	7	sample	sample	NN
cord-006229-7yoilsho	6334	8	groups	group	NNS
cord-006229-7yoilsho	6334	9	are	be	VBP
cord-006229-7yoilsho	6334	10	necessary	necessary	JJ
cord-006229-7yoilsho	6334	11	to	to	TO
cord-006229-7yoilsho	6334	12	confirm	confirm	VB
cord-006229-7yoilsho	6334	13	and	and	CC
cord-006229-7yoilsho	6334	14	validate	validate	VB
cord-006229-7yoilsho	6334	15	our	-PRON-	PRP$
cord-006229-7yoilsho	6334	16	preliminary	preliminary	JJ
cord-006229-7yoilsho	6334	17	findings	finding	NNS
cord-006229-7yoilsho	6334	18	.	.	.
cord-006229-7yoilsho	6335	1	In	in	IN
cord-006229-7yoilsho	6335	2	summary	summary	NN
cord-006229-7yoilsho	6335	3	,	,	,
cord-006229-7yoilsho	6335	4	the	the	DT
cord-006229-7yoilsho	6335	5	presented	present	VBN
cord-006229-7yoilsho	6335	6	approach	approach	NN
cord-006229-7yoilsho	6335	7	provides	provide	VBZ
cord-006229-7yoilsho	6335	8	a	a	DT
cord-006229-7yoilsho	6335	9	first	first	JJ
cord-006229-7yoilsho	6335	10	basis	basis	NN
cord-006229-7yoilsho	6335	11	for	for	IN
cord-006229-7yoilsho	6335	12	comprehensive	comprehensive	JJ
cord-006229-7yoilsho	6335	13	metabolomics	metabolomic	NNS
cord-006229-7yoilsho	6335	14	studies	study	NNS
cord-006229-7yoilsho	6335	15	in	in	IN
cord-006229-7yoilsho	6335	16	human	human	JJ
cord-006229-7yoilsho	6335	17	kidney	kidney	NN
cord-006229-7yoilsho	6335	18	tissue	tissue	NN
cord-006229-7yoilsho	6335	19	and	and	CC
cord-006229-7yoilsho	6335	20	thus	thus	RB
cord-006229-7yoilsho	6335	21	offers	offer	VBZ
cord-006229-7yoilsho	6335	22	great	great	JJ
cord-006229-7yoilsho	6335	23	potential	potential	NN
cord-006229-7yoilsho	6335	24	for	for	IN
cord-006229-7yoilsho	6335	25	the	the	DT
cord-006229-7yoilsho	6335	26	metabolic	metabolic	JJ
cord-006229-7yoilsho	6335	27	characterization	characterization	NN
cord-006229-7yoilsho	6335	28	of	of	IN
cord-006229-7yoilsho	6335	29	ccRCC	ccrcc	NN
cord-006229-7yoilsho	6335	30	with	with	IN
cord-006229-7yoilsho	6335	31	important	important	JJ
cord-006229-7yoilsho	6335	32	prognostic	prognostic	JJ
cord-006229-7yoilsho	6335	33	and	and	CC
cord-006229-7yoilsho	6335	34	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	6335	35	implications	implication	NNS
cord-006229-7yoilsho	6335	36	in	in	IN
cord-006229-7yoilsho	6335	37	the	the	DT
cord-006229-7yoilsho	6335	38	future	future	NN
cord-006229-7yoilsho	6335	39	.	.	.
cord-006229-7yoilsho	6336	1	Introduction	introduction	NN
cord-006229-7yoilsho	6336	2	:	:	:
cord-006229-7yoilsho	6336	3	Clomiphene	Clomiphene	NNP
cord-006229-7yoilsho	6336	4	(	(	-LRB-
cord-006229-7yoilsho	6336	5	CLOM	CLOM	NNP
cord-006229-7yoilsho	6336	6	)	)	-RRB-
cord-006229-7yoilsho	6336	7	citrate	citrate	NN
cord-006229-7yoilsho	6336	8	as	as	IN
cord-006229-7yoilsho	6336	9	mixture	mixture	NN
cord-006229-7yoilsho	6336	10	of	of	IN
cord-006229-7yoilsho	6336	11	trans	trans	NNP
cord-006229-7yoilsho	6336	12	-	-	HYPH
cord-006229-7yoilsho	6336	13	and	and	CC
cord-006229-7yoilsho	6336	14	cis	cis	NNP
cord-006229-7yoilsho	6336	15	-	-	HYPH
cord-006229-7yoilsho	6336	16	isomer	isomer	NNP
cord-006229-7yoilsho	6336	17	(	(	-LRB-
cord-006229-7yoilsho	6336	18	60:40	60:40	NNP
cord-006229-7yoilsho	6336	19	)	)	-RRB-
cord-006229-7yoilsho	6336	20	is	be	VBZ
cord-006229-7yoilsho	6336	21	the	the	DT
cord-006229-7yoilsho	6336	22	first	first	JJ
cord-006229-7yoilsho	6336	23	line	line	NN
cord-006229-7yoilsho	6336	24	therapy	therapy	NN
cord-006229-7yoilsho	6336	25	for	for	IN
cord-006229-7yoilsho	6336	26	the	the	DT
cord-006229-7yoilsho	6336	27	treatment	treatment	NN
cord-006229-7yoilsho	6336	28	of	of	IN
cord-006229-7yoilsho	6336	29	infertility	infertility	NN
cord-006229-7yoilsho	6336	30	caused	cause	VBN
cord-006229-7yoilsho	6336	31	by	by	IN
cord-006229-7yoilsho	6336	32	the	the	DT
cord-006229-7yoilsho	6336	33	polycystic	polycystic	JJ
cord-006229-7yoilsho	6336	34	ovary	ovary	JJ
cord-006229-7yoilsho	6336	35	syndrome	syndrome	NN
cord-006229-7yoilsho	6336	36	.	.	.
cord-006229-7yoilsho	6337	1	Treatment	treatment	NN
cord-006229-7yoilsho	6337	2	schedule	schedule	NN
cord-006229-7yoilsho	6337	3	includes	include	VBZ
cord-006229-7yoilsho	6337	4	dose	dose	JJ
cord-006229-7yoilsho	6337	5	escalation	escalation	NN
cord-006229-7yoilsho	6337	6	from	from	IN
cord-006229-7yoilsho	6337	7	50	50	CD
cord-006229-7yoilsho	6338	1	mg	mg	NNP
cord-006229-7yoilsho	6338	2	/	/	SYM
cord-006229-7yoilsho	6338	3	d	d	NN
cord-006229-7yoilsho	6338	4	CLOM	CLOM	NNP
cord-006229-7yoilsho	6338	5	citrate	citrate	NN
cord-006229-7yoilsho	6338	6	to	to	IN
cord-006229-7yoilsho	6338	7	up	up	IN
cord-006229-7yoilsho	6338	8	to	to	TO
cord-006229-7yoilsho	6338	9	150	150	CD
cord-006229-7yoilsho	6338	10	mg	mg	NN
cord-006229-7yoilsho	6338	11	/	/	SYM
cord-006229-7yoilsho	6338	12	d	d	NN
cord-006229-7yoilsho	6339	1	in	in	IN
cord-006229-7yoilsho	6339	2	case	case	NN
cord-006229-7yoilsho	6339	3	of	of	IN
cord-006229-7yoilsho	6339	4	non	non	JJ
cord-006229-7yoilsho	6339	5	-	-	JJ
cord-006229-7yoilsho	6339	6	ovulation	ovulation	JJ
cord-006229-7yoilsho	6339	7	.	.	.
cord-006229-7yoilsho	6340	1	However	however	RB
cord-006229-7yoilsho	6340	2	,	,	,
cord-006229-7yoilsho	6340	3	therapy	therapy	NN
cord-006229-7yoilsho	6340	4	outcome	outcome	NN
cord-006229-7yoilsho	6340	5	is	be	VBZ
cord-006229-7yoilsho	6340	6	variable	variable	JJ
cord-006229-7yoilsho	6340	7	and	and	CC
cord-006229-7yoilsho	6340	8	approximately	approximately	RB
cord-006229-7yoilsho	6340	9	10	10	CD
cord-006229-7yoilsho	6340	10	-30	-30	CD
cord-006229-7yoilsho	6340	11	%	%	NN
cord-006229-7yoilsho	6340	12	of	of	IN
cord-006229-7yoilsho	6340	13	patients	patient	NNS
cord-006229-7yoilsho	6340	14	do	do	VBP
cord-006229-7yoilsho	6340	15	not	not	RB
cord-006229-7yoilsho	6340	16	benefit	benefit	VB
cord-006229-7yoilsho	6340	17	from	from	IN
cord-006229-7yoilsho	6340	18	CLOM	CLOM	NNP
cord-006229-7yoilsho	6340	19	treatment	treatment	NN
cord-006229-7yoilsho	6340	20	.	.	.
cord-006229-7yoilsho	6341	1	The	the	DT
cord-006229-7yoilsho	6341	2	pro	pro	JJ
cord-006229-7yoilsho	6341	3	-	-	JJ
cord-006229-7yoilsho	6341	4	drug	drug	JJ
cord-006229-7yoilsho	6341	5	CLOM	CLOM	NNP
cord-006229-7yoilsho	6341	6	is	be	VBZ
cord-006229-7yoilsho	6341	7	bioactivated	bioactivate	VBN
cord-006229-7yoilsho	6341	8	via	via	IN
cord-006229-7yoilsho	6341	9	4-hydroxylation	4-hydroxylation	CD
cord-006229-7yoilsho	6341	10	of	of	IN
cord-006229-7yoilsho	6341	11	trans	trans	NNP
cord-006229-7yoilsho	6341	12	-	-	NN
cord-006229-7yoilsho	6341	13	CLOM	CLOM	NNP
cord-006229-7yoilsho	6341	14	by	by	IN
cord-006229-7yoilsho	6341	15	the	the	DT
cord-006229-7yoilsho	6341	16	highly	highly	RB
cord-006229-7yoilsho	6341	17	polymorphic	polymorphic	JJ
cord-006229-7yoilsho	6341	18	cytochrome	cytochrome	NN
cord-006229-7yoilsho	6341	19	P450	p450	NN
cord-006229-7yoilsho	6341	20	(	(	-LRB-
cord-006229-7yoilsho	6341	21	CYP	CYP	NNP
cord-006229-7yoilsho	6341	22	)	)	-RRB-
cord-006229-7yoilsho	6341	23	2D6	2d6	CD
cord-006229-7yoilsho	6341	24	leading	lead	VBG
cord-006229-7yoilsho	6341	25	to	to	IN
cord-006229-7yoilsho	6341	26	the	the	DT
cord-006229-7yoilsho	6341	27	major	major	JJ
cord-006229-7yoilsho	6341	28	active	active	JJ
cord-006229-7yoilsho	6341	29	metabolite	metabolite	NN
cord-006229-7yoilsho	6341	30	trans-4hydroxyclomiphene	trans-4hydroxyclomiphene	NN
cord-006229-7yoilsho	6341	31	(	(	-LRB-
cord-006229-7yoilsho	6341	32	trans-4-OH	trans-4-OH	NNP
cord-006229-7yoilsho	6341	33	-	-	HYPH
cord-006229-7yoilsho	6341	34	CLOM	CLOM	NNP
cord-006229-7yoilsho	6341	35	)	)	-RRB-
cord-006229-7yoilsho	6342	1	[	[	-LRB-
cord-006229-7yoilsho	6342	2	1	1	CD
cord-006229-7yoilsho	6342	3	]	]	-RRB-
cord-006229-7yoilsho	6342	4	.	.	.
cord-006229-7yoilsho	6343	1	Recently	recently	RB
cord-006229-7yoilsho	6343	2	,	,	,
cord-006229-7yoilsho	6343	3	we	-PRON-	PRP
cord-006229-7yoilsho	6343	4	identified	identify	VBD
cord-006229-7yoilsho	6343	5	a	a	DT
cord-006229-7yoilsho	6343	6	less	less	RBR
cord-006229-7yoilsho	6343	7	active	active	JJ
cord-006229-7yoilsho	6343	8	trans-3-OH	trans-3-OH	NNP
cord-006229-7yoilsho	6343	9	-	-	HYPH
cord-006229-7yoilsho	6343	10	CLOM	CLOM	NNP
cord-006229-7yoilsho	6343	11	which	which	WDT
cord-006229-7yoilsho	6343	12	is	be	VBZ
cord-006229-7yoilsho	6343	13	also	also	RB
cord-006229-7yoilsho	6343	14	formed	form	VBN
cord-006229-7yoilsho	6343	15	by	by	IN
cord-006229-7yoilsho	6343	16	CYP2D6	CYP2D6	NNP
cord-006229-7yoilsho	6343	17	.	.	.
cord-006229-7yoilsho	6344	1	Besides	besides	IN
cord-006229-7yoilsho	6344	2	the	the	DT
cord-006229-7yoilsho	6344	3	formation	formation	NN
cord-006229-7yoilsho	6344	4	of	of	IN
cord-006229-7yoilsho	6344	5	the	the	DT
cord-006229-7yoilsho	6344	6	active	active	JJ
cord-006229-7yoilsho	6344	7	metabolites	metabolite	NNS
cord-006229-7yoilsho	6344	8	,	,	,
cord-006229-7yoilsho	6344	9	their	-PRON-	PRP$
cord-006229-7yoilsho	6344	10	plasma	plasma	NN
cord-006229-7yoilsho	6344	11	concentrations	concentration	NNS
cord-006229-7yoilsho	6344	12	are	be	VBP
cord-006229-7yoilsho	6344	13	influenced	influence	VBN
cord-006229-7yoilsho	6344	14	by	by	IN
cord-006229-7yoilsho	6344	15	their	-PRON-	PRP$
cord-006229-7yoilsho	6344	16	clearance	clearance	NN
cord-006229-7yoilsho	6344	17	e.g.	e.g.	RB
cord-006229-7yoilsho	6344	18	via	via	IN
cord-006229-7yoilsho	6344	19	glucuronidation	glucuronidation	NN
cord-006229-7yoilsho	6344	20	and	and	CC
cord-006229-7yoilsho	6344	21	sulfation	sulfation	NN
cord-006229-7yoilsho	6344	22	.	.	.
cord-006229-7yoilsho	6345	1	Here	here	RB
cord-006229-7yoilsho	6345	2	we	-PRON-	PRP
cord-006229-7yoilsho	6345	3	investigated	investigate	VBD
cord-006229-7yoilsho	6345	4	the	the	DT
cord-006229-7yoilsho	6345	5	glucuronidation	glucuronidation	NN
cord-006229-7yoilsho	6345	6	and	and	CC
cord-006229-7yoilsho	6345	7	sulfation	sulfation	NN
cord-006229-7yoilsho	6345	8	of	of	IN
cord-006229-7yoilsho	6345	9	both	both	DT
cord-006229-7yoilsho	6345	10	hydroxyl	hydroxyl	NN
cord-006229-7yoilsho	6345	11	-	-	HYPH
cord-006229-7yoilsho	6345	12	metabolites	metabolite	NNS
cord-006229-7yoilsho	6345	13	.	.	.
cord-006229-7yoilsho	6346	1	Methods	method	NNS
cord-006229-7yoilsho	6346	2	:	:	:
cord-006229-7yoilsho	6346	3	Isoforms	isoform	NNS
cord-006229-7yoilsho	6346	4	of	of	IN
cord-006229-7yoilsho	6346	5	UDP	udp	NN
cord-006229-7yoilsho	6346	6	-	-	HYPH
cord-006229-7yoilsho	6346	7	glucuronosyl	glucuronosyl	NN
cord-006229-7yoilsho	6346	8	-	-	HYPH
cord-006229-7yoilsho	6346	9	transferase	transferase	NN
cord-006229-7yoilsho	6346	10	(	(	-LRB-
cord-006229-7yoilsho	6346	11	UGT	UGT	NNP
cord-006229-7yoilsho	6346	12	)	)	-RRB-
cord-006229-7yoilsho	6346	13	and	and	CC
cord-006229-7yoilsho	6346	14	sulfotransferase	sulfotransferase	NNP
cord-006229-7yoilsho	6346	15	(	(	-LRB-
cord-006229-7yoilsho	6346	16	SULT	SULT	NNP
cord-006229-7yoilsho	6346	17	)	)	-RRB-
cord-006229-7yoilsho	6346	18	responsible	responsible	JJ
cord-006229-7yoilsho	6346	19	for	for	IN
cord-006229-7yoilsho	6346	20	conjugation	conjugation	NN
cord-006229-7yoilsho	6346	21	of	of	IN
cord-006229-7yoilsho	6346	22	OH	OH	NNP
cord-006229-7yoilsho	6346	23	-	-	HYPH
cord-006229-7yoilsho	6346	24	CLOM	CLOM	NNP
cord-006229-7yoilsho	6346	25	were	be	VBD
cord-006229-7yoilsho	6346	26	identified	identify	VBN
cord-006229-7yoilsho	6346	27	using	use	VBG
cord-006229-7yoilsho	6346	28	commercially	commercially	RB
cord-006229-7yoilsho	6346	29	available	available	JJ
cord-006229-7yoilsho	6346	30	supersomes	supersome	NNS
cord-006229-7yoilsho	6346	31	.	.	.
cord-006229-7yoilsho	6347	1	Glucuronidation	glucuronidation	NN
cord-006229-7yoilsho	6347	2	and	and	CC
cord-006229-7yoilsho	6347	3	sulfation	sulfation	NN
cord-006229-7yoilsho	6347	4	kinetics	kinetic	NNS
cord-006229-7yoilsho	6347	5	were	be	VBD
cord-006229-7yoilsho	6347	6	determined	determine	VBN
cord-006229-7yoilsho	6347	7	in	in	IN
cord-006229-7yoilsho	6347	8	pooled	pool	VBN
cord-006229-7yoilsho	6347	9	human	human	JJ
cord-006229-7yoilsho	6347	10	liver	liver	NN
cord-006229-7yoilsho	6347	11	microsomes	microsome	NNS
cord-006229-7yoilsho	6347	12	.	.	.
cord-006229-7yoilsho	6348	1	Conjugated	conjugate	VBN
cord-006229-7yoilsho	6348	2	CLOM	CLOM	NNP
cord-006229-7yoilsho	6348	3	metabolites	metabolite	NNS
cord-006229-7yoilsho	6348	4	were	be	VBD
cord-006229-7yoilsho	6348	5	quantified	quantify	VBN
cord-006229-7yoilsho	6348	6	in	in	IN
cord-006229-7yoilsho	6348	7	plasma	plasma	NN
cord-006229-7yoilsho	6348	8	and	and	CC
cord-006229-7yoilsho	6348	9	urine	urine	NN
cord-006229-7yoilsho	6348	10	samples	sample	NNS
cord-006229-7yoilsho	6348	11	obtained	obtain	VBN
cord-006229-7yoilsho	6348	12	from	from	IN
cord-006229-7yoilsho	6348	13	healthy	healthy	JJ
cord-006229-7yoilsho	6348	14	female	female	JJ
cord-006229-7yoilsho	6348	15	volunteers	volunteer	NNS
cord-006229-7yoilsho	6348	16	who	who	WP
cord-006229-7yoilsho	6348	17	received	receive	VBD
cord-006229-7yoilsho	6348	18	a	a	DT
cord-006229-7yoilsho	6348	19	single	single	JJ
cord-006229-7yoilsho	6348	20	dose	dose	NN
cord-006229-7yoilsho	6348	21	of	of	IN
cord-006229-7yoilsho	6348	22	100	100	CD
cord-006229-7yoilsho	6348	23	mg	mg	NN
cord-006229-7yoilsho	6348	24	CLOM	CLOM	NNP
cord-006229-7yoilsho	6348	25	citrate	citrate	NN
cord-006229-7yoilsho	6348	26	.	.	.
cord-006229-7yoilsho	6349	1	Results	result	NNS
cord-006229-7yoilsho	6349	2	:	:	:
cord-006229-7yoilsho	6350	1	Incubations	incubation	NNS
cord-006229-7yoilsho	6350	2	with	with	IN
cord-006229-7yoilsho	6350	3	human	human	JJ
cord-006229-7yoilsho	6350	4	liver	liver	NN
cord-006229-7yoilsho	6350	5	microsomes	microsome	NNS
cord-006229-7yoilsho	6350	6	revealed	reveal	VBD
cord-006229-7yoilsho	6350	7	an	an	DT
cord-006229-7yoilsho	6350	8	almost	almost	RB
cord-006229-7yoilsho	6350	9	60-fold	60-fold	CD
cord-006229-7yoilsho	6350	10	higher	high	JJR
cord-006229-7yoilsho	6350	11	glucuronidation	glucuronidation	NN
cord-006229-7yoilsho	6350	12	rate	rate	NN
cord-006229-7yoilsho	6350	13	for	for	IN
cord-006229-7yoilsho	6350	14	trans-3-OH	trans-3-OH	NNP
cord-006229-7yoilsho	6350	15	-	-	HYPH
cord-006229-7yoilsho	6350	16	CLOM	CLOM	NNP
cord-006229-7yoilsho	6350	17	,	,	,
cord-006229-7yoilsho	6350	18	which	which	WDT
cord-006229-7yoilsho	6350	19	is	be	VBZ
cord-006229-7yoilsho	6350	20	exclusively	exclusively	RB
cord-006229-7yoilsho	6350	21	catalyzed	catalyze	VBN
cord-006229-7yoilsho	6350	22	by	by	IN
cord-006229-7yoilsho	6350	23	UGT2B7	UGT2B7	NNP
cord-006229-7yoilsho	6350	24	,	,	,
cord-006229-7yoilsho	6350	25	compared	compare	VBN
cord-006229-7yoilsho	6350	26	to	to	IN
cord-006229-7yoilsho	6350	27	the	the	DT
cord-006229-7yoilsho	6350	28	more	more	RBR
cord-006229-7yoilsho	6350	29	potent	potent	JJ
cord-006229-7yoilsho	6350	30	trans-4-OH	trans-4-oh	NN
cord-006229-7yoilsho	6350	31	-	-	HYPH
cord-006229-7yoilsho	6350	32	CLOM	CLOM	NNP
cord-006229-7yoilsho	6350	33	.	.	.
cord-006229-7yoilsho	6351	1	For	for	IN
cord-006229-7yoilsho	6351	2	the	the	DT
cord-006229-7yoilsho	6351	3	latter	latter	JJ
cord-006229-7yoilsho	6351	4	a	a	DT
cord-006229-7yoilsho	6351	5	pattern	pattern	NN
cord-006229-7yoilsho	6351	6	of	of	IN
cord-006229-7yoilsho	6351	7	multiple	multiple	JJ
cord-006229-7yoilsho	6351	8	UGTs	ugt	NNS
cord-006229-7yoilsho	6351	9	was	be	VBD
cord-006229-7yoilsho	6351	10	identified	identify	VBN
cord-006229-7yoilsho	6351	11	.	.	.
cord-006229-7yoilsho	6352	1	In	in	IN
cord-006229-7yoilsho	6352	2	contrast	contrast	NN
cord-006229-7yoilsho	6352	3	,	,	,
cord-006229-7yoilsho	6352	4	the	the	DT
cord-006229-7yoilsho	6352	5	intrinsic	intrinsic	JJ
cord-006229-7yoilsho	6352	6	clearance	clearance	NN
cord-006229-7yoilsho	6352	7	of	of	IN
cord-006229-7yoilsho	6352	8	trans-4-OH	trans-4-OH	NNP
cord-006229-7yoilsho	6352	9	-	-	HYPH
cord-006229-7yoilsho	6352	10	CLOM	CLOM	NNP
cord-006229-7yoilsho	6352	11	to	to	IN
cord-006229-7yoilsho	6352	12	its	-PRON-	PRP$
cord-006229-7yoilsho	6352	13	sulfate	sulfate	NN
cord-006229-7yoilsho	6352	14	is	be	VBZ
cord-006229-7yoilsho	6352	15	16-fold	16-fold	JJ
cord-006229-7yoilsho	6352	16	higher	high	JJR
cord-006229-7yoilsho	6352	17	compared	compare	VBN
cord-006229-7yoilsho	6352	18	to	to	IN
cord-006229-7yoilsho	6352	19	3-OH	3-oh	CD
cord-006229-7yoilsho	6352	20	-	-	:
cord-006229-7yoilsho	6352	21	CLOM	CLOM	NNP
cord-006229-7yoilsho	6352	22	.	.	.
cord-006229-7yoilsho	6353	1	For	for	IN
cord-006229-7yoilsho	6353	2	both	both	DT
cord-006229-7yoilsho	6353	3	metabolites	metabolite	NNS
cord-006229-7yoilsho	6353	4	a	a	DT
cord-006229-7yoilsho	6353	5	participation	participation	NN
cord-006229-7yoilsho	6353	6	of	of	IN
cord-006229-7yoilsho	6353	7	SULT1A1	sult1a1	NN
cord-006229-7yoilsho	6353	8	and	and	CC
cord-006229-7yoilsho	6353	9	SULT1E1	SULT1E1	NNP
cord-006229-7yoilsho	6353	10	was	be	VBD
cord-006229-7yoilsho	6353	11	identified	identify	VBN
cord-006229-7yoilsho	6353	12	.	.	.
cord-006229-7yoilsho	6354	1	These	these	DT
cord-006229-7yoilsho	6354	2	results	result	NNS
cord-006229-7yoilsho	6354	3	were	be	VBD
cord-006229-7yoilsho	6354	4	in	in	IN
cord-006229-7yoilsho	6354	5	line	line	NN
cord-006229-7yoilsho	6354	6	with	with	IN
cord-006229-7yoilsho	6354	7	previous	previous	JJ
cord-006229-7yoilsho	6354	8	studies	study	NNS
cord-006229-7yoilsho	6354	9	,	,	,
cord-006229-7yoilsho	6354	10	which	which	WDT
cord-006229-7yoilsho	6354	11	identified	identify	VBD
cord-006229-7yoilsho	6354	12	the	the	DT
cord-006229-7yoilsho	6354	13	same	same	JJ
cord-006229-7yoilsho	6354	14	SULTs	sult	NNS
cord-006229-7yoilsho	6354	15	[	[	-LRB-
cord-006229-7yoilsho	6354	16	2	2	CD
cord-006229-7yoilsho	6354	17	]	]	-RRB-
cord-006229-7yoilsho	6354	18	and	and	CC
cord-006229-7yoilsho	6354	19	UGTs	ugt	NNS
cord-006229-7yoilsho	6354	20	[	[	-LRB-
cord-006229-7yoilsho	6354	21	3	3	CD
cord-006229-7yoilsho	6354	22	]	]	-RRB-
cord-006229-7yoilsho	6354	23	responsible	responsible	JJ
cord-006229-7yoilsho	6354	24	for	for	IN
cord-006229-7yoilsho	6354	25	the	the	DT
cord-006229-7yoilsho	6354	26	conjugation	conjugation	NN
cord-006229-7yoilsho	6354	27	of	of	IN
cord-006229-7yoilsho	6354	28	the	the	DT
cord-006229-7yoilsho	6354	29	structurally	structurally	RB
cord-006229-7yoilsho	6354	30	related	relate	VBN
cord-006229-7yoilsho	6354	31	trans-4-hydroxytamoxifen	trans-4-hydroxytamoxifen	NNP
cord-006229-7yoilsho	6354	32	.	.	.
cord-006229-7yoilsho	6355	1	In	in	IN
cord-006229-7yoilsho	6355	2	addition	addition	NN
cord-006229-7yoilsho	6355	3	,	,	,
cord-006229-7yoilsho	6355	4	in	in	IN
cord-006229-7yoilsho	6355	5	vivo	vivo	NN
cord-006229-7yoilsho	6355	6	data	datum	NNS
cord-006229-7yoilsho	6355	7	from	from	IN
cord-006229-7yoilsho	6355	8	plasma	plasma	NN
cord-006229-7yoilsho	6355	9	and	and	CC
cord-006229-7yoilsho	6355	10	urine	urine	NN
cord-006229-7yoilsho	6355	11	samples	sample	NNS
cord-006229-7yoilsho	6355	12	confirmed	confirm	VBD
cord-006229-7yoilsho	6355	13	the	the	DT
cord-006229-7yoilsho	6355	14	reverse	reverse	JJ
cord-006229-7yoilsho	6355	15	regioselective	regioselective	JJ
cord-006229-7yoilsho	6355	16	glucuronidation	glucuronidation	NN
cord-006229-7yoilsho	6355	17	and	and	CC
cord-006229-7yoilsho	6355	18	sulfation	sulfation	NN
cord-006229-7yoilsho	6355	19	of	of	IN
cord-006229-7yoilsho	6355	20	trans-3-OH	trans-3-OH	NNP
cord-006229-7yoilsho	6355	21	-	-	HYPH
cord-006229-7yoilsho	6355	22	CLOM	CLOM	NNP
cord-006229-7yoilsho	6355	23	and	and	CC
cord-006229-7yoilsho	6355	24	trans-4-OH	trans-4-OH	NNP
cord-006229-7yoilsho	6355	25	-	-	HYPH
cord-006229-7yoilsho	6355	26	CLOM	CLOM	NNP
cord-006229-7yoilsho	6355	27	.	.	.
cord-006229-7yoilsho	6356	1	Overall	overall	RB
cord-006229-7yoilsho	6356	2	,	,	,
cord-006229-7yoilsho	6356	3	concentrations	concentration	NNS
cord-006229-7yoilsho	6356	4	of	of	IN
cord-006229-7yoilsho	6356	5	CLOMglucuronides	clomglucuronide	NNS
cord-006229-7yoilsho	6356	6	were	be	VBD
cord-006229-7yoilsho	6356	7	significantly	significantly	RB
cord-006229-7yoilsho	6356	8	higher	high	JJR
cord-006229-7yoilsho	6356	9	than	than	IN
cord-006229-7yoilsho	6356	10	those	those	DT
cord-006229-7yoilsho	6356	11	of	of	IN
cord-006229-7yoilsho	6356	12	sulfates	sulfate	NNS
cord-006229-7yoilsho	6356	13	.	.	.
cord-006229-7yoilsho	6357	1	Highest	high	JJS
cord-006229-7yoilsho	6357	2	concentrations	concentration	NNS
cord-006229-7yoilsho	6357	3	in	in	IN
cord-006229-7yoilsho	6357	4	plasma	plasma	NN
cord-006229-7yoilsho	6357	5	and	and	CC
cord-006229-7yoilsho	6357	6	urine	urine	NN
cord-006229-7yoilsho	6357	7	samples	sample	NNS
cord-006229-7yoilsho	6357	8	were	be	VBD
cord-006229-7yoilsho	6357	9	measured	measure	VBN
cord-006229-7yoilsho	6357	10	for	for	IN
cord-006229-7yoilsho	6357	11	trans	trans	JJ
cord-006229-7yoilsho	6357	12	-	-	JJ
cord-006229-7yoilsho	6357	13	CLOM-3-O	CLOM-3-O	NNP
cord-006229-7yoilsho	6357	14	-	-	HYPH
cord-006229-7yoilsho	6357	15	glucuronide	glucuronide	NN
cord-006229-7yoilsho	6357	16	.	.	.
cord-006229-7yoilsho	6358	1	Conclusion	conclusion	NN
cord-006229-7yoilsho	6358	2	:	:	:
cord-006229-7yoilsho	6359	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	6359	2	results	result	NNS
cord-006229-7yoilsho	6359	3	suggest	suggest	VBP
cord-006229-7yoilsho	6359	4	a	a	DT
cord-006229-7yoilsho	6359	5	new	new	JJ
cord-006229-7yoilsho	6359	6	metabolic	metabolic	JJ
cord-006229-7yoilsho	6359	7	route	route	NN
cord-006229-7yoilsho	6359	8	via	via	IN
cord-006229-7yoilsho	6359	9	trans-3-OH	trans-3-OH	NNP
cord-006229-7yoilsho	6359	10	-	-	HYPH
cord-006229-7yoilsho	6359	11	CLOM	CLOM	NNP
cord-006229-7yoilsho	6359	12	which	which	WDT
cord-006229-7yoilsho	6359	13	appears	appear	VBZ
cord-006229-7yoilsho	6359	14	to	to	TO
cord-006229-7yoilsho	6359	15	be	be	VB
cord-006229-7yoilsho	6359	16	a	a	DT
cord-006229-7yoilsho	6359	17	potential	potential	JJ
cord-006229-7yoilsho	6359	18	inactivation	inactivation	NN
cord-006229-7yoilsho	6359	19	pathway	pathway	NN
cord-006229-7yoilsho	6359	20	of	of	IN
cord-006229-7yoilsho	6359	21	CLOM	CLOM	NNP
cord-006229-7yoilsho	6359	22	.	.	.
cord-006229-7yoilsho	6360	1	1	1	CD
cord-006229-7yoilsho	6360	2	1	1	CD
cord-006229-7yoilsho	6360	3	Institut	Institut	NNP
cord-006229-7yoilsho	6360	4	für	für	NNP
cord-006229-7yoilsho	6360	5	Pharmakologie	Pharmakologie	NNP
cord-006229-7yoilsho	6360	6	und	und	XX
cord-006229-7yoilsho	6361	1	Toxikologie	Toxikologie	NNP
cord-006229-7yoilsho	6361	2	der	der	NNP
cord-006229-7yoilsho	6361	3	Bundeswehr	Bundeswehr	NNP
cord-006229-7yoilsho	6361	4	,	,	,
cord-006229-7yoilsho	6361	5	München	München	NNP
cord-006229-7yoilsho	6361	6	,	,	,
cord-006229-7yoilsho	6361	7	Germany	Germany	NNP
cord-006229-7yoilsho	6362	1	For	for	IN
cord-006229-7yoilsho	6362	2	decades	decade	NNS
cord-006229-7yoilsho	6362	3	the	the	DT
cord-006229-7yoilsho	6362	4	biological	biological	JJ
cord-006229-7yoilsho	6362	5	effect	effect	NN
cord-006229-7yoilsho	6362	6	of	of	IN
cord-006229-7yoilsho	6362	7	SM	SM	NNP
cord-006229-7yoilsho	6362	8	has	have	VBZ
cord-006229-7yoilsho	6362	9	been	be	VBN
cord-006229-7yoilsho	6362	10	investigated	investigate	VBN
cord-006229-7yoilsho	6362	11	.	.	.
cord-006229-7yoilsho	6363	1	It	-PRON-	PRP
cord-006229-7yoilsho	6363	2	is	be	VBZ
cord-006229-7yoilsho	6363	3	well	well	RB
cord-006229-7yoilsho	6363	4	known	know	VBN
cord-006229-7yoilsho	6363	5	how	how	WRB
cord-006229-7yoilsho	6363	6	SM	SM	NNP
cord-006229-7yoilsho	6363	7	interacts	interact	VBZ
cord-006229-7yoilsho	6363	8	and	and	CC
cord-006229-7yoilsho	6363	9	destroys	destroy	VBZ
cord-006229-7yoilsho	6363	10	cells	cell	NNS
cord-006229-7yoilsho	6363	11	.	.	.
cord-006229-7yoilsho	6364	1	Unfortunately	unfortunately	RB
cord-006229-7yoilsho	6364	2	,	,	,
cord-006229-7yoilsho	6364	3	it	-PRON-	PRP
cord-006229-7yoilsho	6364	4	is	be	VBZ
cord-006229-7yoilsho	6364	5	still	still	RB
cord-006229-7yoilsho	6364	6	unknown	unknown	JJ
cord-006229-7yoilsho	6364	7	if	if	IN
cord-006229-7yoilsho	6364	8	and	and	CC
cord-006229-7yoilsho	6364	9	how	how	WRB
cord-006229-7yoilsho	6364	10	a	a	DT
cord-006229-7yoilsho	6364	11	cell	cell	NN
cord-006229-7yoilsho	6364	12	can	can	MD
cord-006229-7yoilsho	6364	13	become	become	VB
cord-006229-7yoilsho	6364	14	resistant	resistant	JJ
cord-006229-7yoilsho	6364	15	against	against	IN
cord-006229-7yoilsho	6364	16	SM	SM	NNP
cord-006229-7yoilsho	6364	17	.	.	.
cord-006229-7yoilsho	6365	1	Within	within	IN
cord-006229-7yoilsho	6365	2	the	the	DT
cord-006229-7yoilsho	6365	3	here	here	RB
cord-006229-7yoilsho	6365	4	described	describe	VBN
cord-006229-7yoilsho	6365	5	experiments	experiment	NNS
cord-006229-7yoilsho	6365	6	we	-PRON-	PRP
cord-006229-7yoilsho	6365	7	investigated	investigate	VBD
cord-006229-7yoilsho	6365	8	a	a	DT
cord-006229-7yoilsho	6365	9	new	new	JJ
cord-006229-7yoilsho	6365	10	approach	approach	NN
cord-006229-7yoilsho	6365	11	adapting	adapt	VBG
cord-006229-7yoilsho	6365	12	cells	cell	NNS
cord-006229-7yoilsho	6365	13	to	to	IN
cord-006229-7yoilsho	6365	14	the	the	DT
cord-006229-7yoilsho	6365	15	presence	presence	NN
cord-006229-7yoilsho	6365	16	of	of	IN
cord-006229-7yoilsho	6365	17	SM	SM	NNP
cord-006229-7yoilsho	6365	18	.	.	.
cord-006229-7yoilsho	6366	1	Over	over	IN
cord-006229-7yoilsho	6366	2	a	a	DT
cord-006229-7yoilsho	6366	3	time	time	NN
cord-006229-7yoilsho	6366	4	period	period	NN
cord-006229-7yoilsho	6366	5	of	of	IN
cord-006229-7yoilsho	6366	6	nearly	nearly	RB
cord-006229-7yoilsho	6366	7	three	three	CD
cord-006229-7yoilsho	6366	8	years	year	NNS
cord-006229-7yoilsho	6366	9	the	the	DT
cord-006229-7yoilsho	6366	10	cells	cell	NNS
cord-006229-7yoilsho	6366	11	were	be	VBD
cord-006229-7yoilsho	6366	12	cultivated	cultivate	VBN
cord-006229-7yoilsho	6366	13	in	in	IN
cord-006229-7yoilsho	6366	14	presence	presence	NN
cord-006229-7yoilsho	6366	15	of	of	IN
cord-006229-7yoilsho	6366	16	SM	SM	NNP
cord-006229-7yoilsho	6366	17	with	with	IN
cord-006229-7yoilsho	6366	18	increasing	increase	VBG
cord-006229-7yoilsho	6366	19	concentrations	concentration	NNS
cord-006229-7yoilsho	6366	20	.	.	.
cord-006229-7yoilsho	6367	1	Before	before	IN
cord-006229-7yoilsho	6367	2	starting	start	VBG
cord-006229-7yoilsho	6367	3	the	the	DT
cord-006229-7yoilsho	6367	4	initial	initial	JJ
cord-006229-7yoilsho	6367	5	SM	sm	NN
cord-006229-7yoilsho	6367	6	sensitivity	sensitivity	NN
cord-006229-7yoilsho	6367	7	was	be	VBD
cord-006229-7yoilsho	6367	8	investigated	investigate	VBN
cord-006229-7yoilsho	6367	9	.	.	.
cord-006229-7yoilsho	6368	1	At	at	IN
cord-006229-7yoilsho	6368	2	the	the	DT
cord-006229-7yoilsho	6368	3	beginning	beginning	NN
cord-006229-7yoilsho	6368	4	cells	cell	NNS
cord-006229-7yoilsho	6368	5	were	be	VBD
cord-006229-7yoilsho	6368	6	cultivated	cultivate	VBN
cord-006229-7yoilsho	6368	7	with	with	IN
cord-006229-7yoilsho	6368	8	a	a	DT
cord-006229-7yoilsho	6368	9	concentration	concentration	NN
cord-006229-7yoilsho	6368	10	of	of	IN
cord-006229-7yoilsho	6368	11	0.07	0.07	CD
cord-006229-7yoilsho	6368	12	µM	µm	NN
cord-006229-7yoilsho	6368	13	SM	SM	NNP
cord-006229-7yoilsho	6368	14	(	(	-LRB-
cord-006229-7yoilsho	6368	15	IC	IC	NNP
cord-006229-7yoilsho	6368	16	10	10	CD
cord-006229-7yoilsho	6368	17	)	)	-RRB-
cord-006229-7yoilsho	6368	18	.	.	.
cord-006229-7yoilsho	6369	1	Today	today	NN
cord-006229-7yoilsho	6369	2	the	the	DT
cord-006229-7yoilsho	6369	3	cells	cell	NNS
cord-006229-7yoilsho	6369	4	are	be	VBP
cord-006229-7yoilsho	6369	5	able	able	JJ
cord-006229-7yoilsho	6369	6	to	to	TO
cord-006229-7yoilsho	6369	7	tolerate	tolerate	VB
cord-006229-7yoilsho	6369	8	a	a	DT
cord-006229-7yoilsho	6369	9	concentration	concentration	NN
cord-006229-7yoilsho	6369	10	of	of	IN
cord-006229-7yoilsho	6369	11	7.2	7.2	CD
cord-006229-7yoilsho	6369	12	µM	µm	CD
cord-006229-7yoilsho	6369	13	SM	sm	NN
cord-006229-7yoilsho	6369	14	(	(	-LRB-
cord-006229-7yoilsho	6369	15	IC	IC	NNP
cord-006229-7yoilsho	6369	16	90	90	CD
cord-006229-7yoilsho	6369	17	)	)	-RRB-
cord-006229-7yoilsho	6369	18	,	,	,
cord-006229-7yoilsho	6369	19	which	which	WDT
cord-006229-7yoilsho	6369	20	reflects	reflect	VBZ
cord-006229-7yoilsho	6369	21	to	to	IN
cord-006229-7yoilsho	6369	22	a	a	DT
cord-006229-7yoilsho	6369	23	concentration	concentration	NN
cord-006229-7yoilsho	6369	24	of	of	IN
cord-006229-7yoilsho	6369	25	which	which	WDT
cord-006229-7yoilsho	6369	26	90	90	CD
cord-006229-7yoilsho	6369	27	%	%	NN
cord-006229-7yoilsho	6369	28	of	of	IN
cord-006229-7yoilsho	6369	29	the	the	DT
cord-006229-7yoilsho	6369	30	original	original	JJ
cord-006229-7yoilsho	6369	31	cells	cell	NNS
cord-006229-7yoilsho	6369	32	would	would	MD
cord-006229-7yoilsho	6369	33	have	have	VB
cord-006229-7yoilsho	6369	34	died	die	VBN
cord-006229-7yoilsho	6369	35	.	.	.
cord-006229-7yoilsho	6370	1	To	to	TO
cord-006229-7yoilsho	6370	2	determine	determine	VB
cord-006229-7yoilsho	6370	3	cellular	cellular	JJ
cord-006229-7yoilsho	6370	4	characteristics	characteristic	NNS
cord-006229-7yoilsho	6370	5	,	,	,
cord-006229-7yoilsho	6370	6	the	the	DT
cord-006229-7yoilsho	6370	7	resistant	resistant	JJ
cord-006229-7yoilsho	6370	8	cells	cell	NNS
cord-006229-7yoilsho	6370	9	were	be	VBD
cord-006229-7yoilsho	6370	10	compared	compare	VBN
cord-006229-7yoilsho	6370	11	with	with	IN
cord-006229-7yoilsho	6370	12	wildtype	wildtype	JJ
cord-006229-7yoilsho	6370	13	cells	cell	NNS
cord-006229-7yoilsho	6370	14	.	.	.
cord-006229-7yoilsho	6371	1	The	the	DT
cord-006229-7yoilsho	6371	2	following	follow	VBG
cord-006229-7yoilsho	6371	3	cell	cell	NN
cord-006229-7yoilsho	6371	4	characteristics	characteristic	NNS
cord-006229-7yoilsho	6371	5	were	be	VBD
cord-006229-7yoilsho	6371	6	investigated	investigate	VBN
cord-006229-7yoilsho	6371	7	:	:	:
cord-006229-7yoilsho	6371	8	proliferation	proliferation	NN
cord-006229-7yoilsho	6371	9	,	,	,
cord-006229-7yoilsho	6371	10	apoptosis	apoptosis	NN
cord-006229-7yoilsho	6371	11	,	,	,
cord-006229-7yoilsho	6371	12	clonogenicity	clonogenicity	NN
cord-006229-7yoilsho	6371	13	,	,	,
cord-006229-7yoilsho	6371	14	size	size	NN
cord-006229-7yoilsho	6371	15	of	of	IN
cord-006229-7yoilsho	6371	16	nuclei	nucleus	NNS
cord-006229-7yoilsho	6371	17	and	and	CC
cord-006229-7yoilsho	6371	18	cytoplasm	cytoplasm	NN
cord-006229-7yoilsho	6371	19	,	,	,
cord-006229-7yoilsho	6371	20	cell	cell	NN
cord-006229-7yoilsho	6371	21	-	-	HYPH
cord-006229-7yoilsho	6371	22	cell	cell	NN
cord-006229-7yoilsho	6371	23	contacts	contact	NNS
cord-006229-7yoilsho	6371	24	,	,	,
cord-006229-7yoilsho	6371	25	DNA	dna	NN
cord-006229-7yoilsho	6371	26	adducts	adduct	NNS
cord-006229-7yoilsho	6371	27	formation	formation	NN
cord-006229-7yoilsho	6371	28	,	,	,
cord-006229-7yoilsho	6371	29	secretome	secretome	NNP
cord-006229-7yoilsho	6371	30	,	,	,
cord-006229-7yoilsho	6371	31	screening	screening	NN
cord-006229-7yoilsho	6371	32	of	of	IN
cord-006229-7yoilsho	6371	33	miRNA	miRNA	NNP
cord-006229-7yoilsho	6371	34	expression	expression	NN
cord-006229-7yoilsho	6371	35	,	,	,
cord-006229-7yoilsho	6371	36	next	next	JJ
cord-006229-7yoilsho	6371	37	generation	generation	NN
cord-006229-7yoilsho	6371	38	sequencing	sequencing	NN
cord-006229-7yoilsho	6371	39	,	,	,
cord-006229-7yoilsho	6371	40	vital	vital	JJ
cord-006229-7yoilsho	6371	41	observation	observation	NN
cord-006229-7yoilsho	6371	42	and	and	CC
cord-006229-7yoilsho	6371	43	scratch	scratch	NN
cord-006229-7yoilsho	6371	44	assay	assay	NN
cord-006229-7yoilsho	6371	45	,	,	,
cord-006229-7yoilsho	6371	46	NAD(P	NAD(P	NNP
cord-006229-7yoilsho	6371	47	)	)	-RRB-
cord-006229-7yoilsho	6372	1	+	+	CC
cord-006229-7yoilsho	6372	2	/NAD(P)H	/nad(p)h	NN
cord-006229-7yoilsho	6372	3	,	,	,
cord-006229-7yoilsho	6372	4	H	h	NN
cord-006229-7yoilsho	6372	5	2	2	CD
cord-006229-7yoilsho	6372	6	O	o	NN
cord-006229-7yoilsho	6372	7	2	2	CD
cord-006229-7yoilsho	6372	8	,	,	,
cord-006229-7yoilsho	6372	9	glutathione	glutathione	NN
cord-006229-7yoilsho	6372	10	,	,	,
cord-006229-7yoilsho	6373	1	Ca	ca	RB
cord-006229-7yoilsho	6373	2	2	2	CD
cord-006229-7yoilsho	6374	1	+	+	CC
cord-006229-7yoilsho	6374	2	-influx	-influx	HYPH
cord-006229-7yoilsho	6374	3	,	,	,
cord-006229-7yoilsho	6374	4	MDRchannels	mdrchannel	NNS
cord-006229-7yoilsho	6374	5	,	,	,
cord-006229-7yoilsho	6374	6	resistance	resistance	NN
cord-006229-7yoilsho	6374	7	to	to	IN
cord-006229-7yoilsho	6374	8	other	other	JJ
cord-006229-7yoilsho	6374	9	alkylating	alkylating	JJ
cord-006229-7yoilsho	6374	10	agents	agent	NNS
cord-006229-7yoilsho	6374	11	and	and	CC
cord-006229-7yoilsho	6374	12	the	the	DT
cord-006229-7yoilsho	6374	13	reversibility	reversibility	NN
cord-006229-7yoilsho	6374	14	of	of	IN
cord-006229-7yoilsho	6374	15	the	the	DT
cord-006229-7yoilsho	6374	16	resistance	resistance	NN
cord-006229-7yoilsho	6374	17	.	.	.
cord-006229-7yoilsho	6375	1	The	the	DT
cord-006229-7yoilsho	6375	2	resistant	resistant	JJ
cord-006229-7yoilsho	6375	3	cells	cell	NNS
cord-006229-7yoilsho	6375	4	demonstrate	demonstrate	VBP
cord-006229-7yoilsho	6375	5	smaller	small	JJR
cord-006229-7yoilsho	6375	6	nuclei	nucleus	NNS
cord-006229-7yoilsho	6375	7	and	and	CC
cord-006229-7yoilsho	6375	8	cytoplasm	cytoplasm	NN
cord-006229-7yoilsho	6375	9	,	,	,
cord-006229-7yoilsho	6375	10	less	less	JJR
cord-006229-7yoilsho	6375	11	DNA	dna	NN
cord-006229-7yoilsho	6375	12	adducts	adduct	NNS
cord-006229-7yoilsho	6375	13	,	,	,
cord-006229-7yoilsho	6375	14	a	a	DT
cord-006229-7yoilsho	6375	15	higher	high	JJR
cord-006229-7yoilsho	6375	16	clonogenicity	clonogenicity	NN
cord-006229-7yoilsho	6375	17	as	as	RB
cord-006229-7yoilsho	6375	18	well	well	RB
cord-006229-7yoilsho	6375	19	as	as	IN
cord-006229-7yoilsho	6375	20	proliferation	proliferation	NN
cord-006229-7yoilsho	6375	21	and	and	CC
cord-006229-7yoilsho	6375	22	less	less	JJR
cord-006229-7yoilsho	6375	23	apoptosis	apoptosis	NN
cord-006229-7yoilsho	6375	24	.	.	.
cord-006229-7yoilsho	6376	1	The	the	DT
cord-006229-7yoilsho	6376	2	secretome	secretome	NN
cord-006229-7yoilsho	6376	3	analysis	analysis	NN
cord-006229-7yoilsho	6376	4	showed	show	VBD
cord-006229-7yoilsho	6376	5	an	an	DT
cord-006229-7yoilsho	6376	6	up	up	JJ
cord-006229-7yoilsho	6376	7	-	-	HYPH
cord-006229-7yoilsho	6376	8	regulation	regulation	NN
cord-006229-7yoilsho	6376	9	of	of	IN
cord-006229-7yoilsho	6376	10	anti	anti	JJ
cord-006229-7yoilsho	6376	11	-	-	JJ
cord-006229-7yoilsho	6376	12	apoptotic	apoptotic	JJ
cord-006229-7yoilsho	6376	13	acting	acting	NN
cord-006229-7yoilsho	6376	14	cytokines	cytokine	NNS
cord-006229-7yoilsho	6376	15	Timp	Timp	NNP
cord-006229-7yoilsho	6376	16	and	and	CC
cord-006229-7yoilsho	6376	17	Ang	Ang	NNP
cord-006229-7yoilsho	6376	18	and	and	CC
cord-006229-7yoilsho	6376	19	the	the	DT
cord-006229-7yoilsho	6376	20	proproliferative	proproliferative	JJ
cord-006229-7yoilsho	6376	21	acting	act	VBG
cord-006229-7yoilsho	6376	22	cytokines	cytokine	NNS
cord-006229-7yoilsho	6376	23	Timp	Timp	NNP
cord-006229-7yoilsho	6376	24	and	and	CC
cord-006229-7yoilsho	6376	25	PDGF	PDGF	NNP
cord-006229-7yoilsho	6376	26	-	-	HYPH
cord-006229-7yoilsho	6376	27	AA	AA	NNP
cord-006229-7yoilsho	6376	28	.	.	.
cord-006229-7yoilsho	6377	1	In	in	IN
cord-006229-7yoilsho	6377	2	contrast	contrast	NN
cord-006229-7yoilsho	6377	3	,	,	,
cord-006229-7yoilsho	6377	4	immunologically	immunologically	RB
cord-006229-7yoilsho	6377	5	active	active	JJ
cord-006229-7yoilsho	6377	6	cytokines	cytokine	NNS
cord-006229-7yoilsho	6377	7	were	be	VBD
cord-006229-7yoilsho	6377	8	down	down	RB
cord-006229-7yoilsho	6377	9	-	-	HYPH
cord-006229-7yoilsho	6377	10	regulated	regulate	VBN
cord-006229-7yoilsho	6377	11	.	.	.
cord-006229-7yoilsho	6378	1	Concerning	concern	VBG
cord-006229-7yoilsho	6378	2	cell	cell	NN
cord-006229-7yoilsho	6378	3	-	-	HYPH
cord-006229-7yoilsho	6378	4	cell	cell	NN
cord-006229-7yoilsho	6378	5	contacts	contact	NNS
cord-006229-7yoilsho	6378	6	no	no	DT
cord-006229-7yoilsho	6378	7	differences	difference	NNS
cord-006229-7yoilsho	6378	8	were	be	VBD
cord-006229-7yoilsho	6378	9	seen	see	VBN
cord-006229-7yoilsho	6378	10	.	.	.
cord-006229-7yoilsho	6379	1	In	in	IN
cord-006229-7yoilsho	6379	2	the	the	DT
cord-006229-7yoilsho	6379	3	miRNA	miRNA	NNP
cord-006229-7yoilsho	6379	4	screening	screen	VBG
cord-006229-7yoilsho	6379	5	49	49	CD
cord-006229-7yoilsho	6379	6	significant	significant	JJ
cord-006229-7yoilsho	6379	7	up	up	RB
cord-006229-7yoilsho	6379	8	-	-	HYPH
cord-006229-7yoilsho	6379	9	regulated	regulate	VBN
cord-006229-7yoilsho	6379	10	and	and	CC
cord-006229-7yoilsho	6379	11	20	20	CD
cord-006229-7yoilsho	6379	12	significant	significant	JJ
cord-006229-7yoilsho	6379	13	down	down	RB
cord-006229-7yoilsho	6379	14	-	-	HYPH
cord-006229-7yoilsho	6379	15	regulated	regulate	VBN
cord-006229-7yoilsho	6379	16	miRNAs	miRNAs	NNP
cord-006229-7yoilsho	6379	17	have	have	VBP
cord-006229-7yoilsho	6379	18	been	be	VBN
cord-006229-7yoilsho	6379	19	observed	observe	VBN
cord-006229-7yoilsho	6379	20	.	.	.
cord-006229-7yoilsho	6380	1	Noteworthy	Noteworthy	NNP
cord-006229-7yoilsho	6380	2	was	be	VBD
cord-006229-7yoilsho	6380	3	the	the	DT
cord-006229-7yoilsho	6380	4	regulation	regulation	NN
cord-006229-7yoilsho	6380	5	of	of	IN
cord-006229-7yoilsho	6380	6	various	various	JJ
cord-006229-7yoilsho	6380	7	members	member	NNS
cord-006229-7yoilsho	6380	8	of	of	IN
cord-006229-7yoilsho	6380	9	11	11	CD
cord-006229-7yoilsho	6380	10	different	different	JJ
cord-006229-7yoilsho	6380	11	families	family	NNS
cord-006229-7yoilsho	6380	12	.	.	.
cord-006229-7yoilsho	6381	1	During	during	IN
cord-006229-7yoilsho	6381	2	vital	vital	JJ
cord-006229-7yoilsho	6381	3	observation	observation	NN
cord-006229-7yoilsho	6381	4	and	and	CC
cord-006229-7yoilsho	6381	5	in	in	IN
cord-006229-7yoilsho	6381	6	a	a	DT
cord-006229-7yoilsho	6381	7	scratch	scratch	NN
cord-006229-7yoilsho	6381	8	-	-	HYPH
cord-006229-7yoilsho	6381	9	assay	assay	NN
cord-006229-7yoilsho	6381	10	the	the	DT
cord-006229-7yoilsho	6381	11	resistant	resistant	JJ
cord-006229-7yoilsho	6381	12	cells	cell	NNS
cord-006229-7yoilsho	6381	13	were	be	VBD
cord-006229-7yoilsho	6381	14	show	show	VBP
cord-006229-7yoilsho	6381	15	to	to	TO
cord-006229-7yoilsho	6381	16	have	have	VB
cord-006229-7yoilsho	6381	17	disadvantages	disadvantage	NNS
cord-006229-7yoilsho	6381	18	.	.	.
cord-006229-7yoilsho	6382	1	The	the	DT
cord-006229-7yoilsho	6382	2	observed	observed	JJ
cord-006229-7yoilsho	6382	3	resistance	resistance	NN
cord-006229-7yoilsho	6382	4	was	be	VBD
cord-006229-7yoilsho	6382	5	not	not	RB
cord-006229-7yoilsho	6382	6	unique	unique	JJ
cord-006229-7yoilsho	6382	7	for	for	IN
cord-006229-7yoilsho	6382	8	SM	sm	NN
cord-006229-7yoilsho	6382	9	but	but	CC
cord-006229-7yoilsho	6382	10	also	also	RB
cord-006229-7yoilsho	6382	11	towards	towards	IN
cord-006229-7yoilsho	6382	12	other	other	JJ
cord-006229-7yoilsho	6382	13	alkylating	alkylating	JJ
cord-006229-7yoilsho	6382	14	agents	agent	NNS
cord-006229-7yoilsho	6382	15	and	and	CC
cord-006229-7yoilsho	6382	16	cytostatic	cytostatic	JJ
cord-006229-7yoilsho	6382	17	drugs	drug	NNS
cord-006229-7yoilsho	6382	18	.	.	.
cord-006229-7yoilsho	6383	1	By	by	IN
cord-006229-7yoilsho	6383	2	analyzing	analyze	VBG
cord-006229-7yoilsho	6383	3	the	the	DT
cord-006229-7yoilsho	6383	4	reversibility	reversibility	NN
cord-006229-7yoilsho	6383	5	cells	cell	NNS
cord-006229-7yoilsho	6383	6	stayed	stay	VBD
cord-006229-7yoilsho	6383	7	resistant	resistant	JJ
cord-006229-7yoilsho	6383	8	over	over	IN
cord-006229-7yoilsho	6383	9	more	more	JJR
cord-006229-7yoilsho	6383	10	than	than	IN
cord-006229-7yoilsho	6383	11	35	35	CD
cord-006229-7yoilsho	6383	12	weeks	week	NNS
cord-006229-7yoilsho	6383	13	.	.	.
cord-006229-7yoilsho	6384	1	In	in	IN
cord-006229-7yoilsho	6384	2	conclusion	conclusion	NN
cord-006229-7yoilsho	6384	3	,	,	,
cord-006229-7yoilsho	6384	4	many	many	JJ
cord-006229-7yoilsho	6384	5	aspects	aspect	NNS
cord-006229-7yoilsho	6384	6	investigated	investigate	VBN
cord-006229-7yoilsho	6384	7	in	in	IN
cord-006229-7yoilsho	6384	8	this	this	DT
cord-006229-7yoilsho	6384	9	study	study	NN
cord-006229-7yoilsho	6384	10	have	have	VBP
cord-006229-7yoilsho	6384	11	an	an	DT
cord-006229-7yoilsho	6384	12	influence	influence	NN
cord-006229-7yoilsho	6384	13	on	on	IN
cord-006229-7yoilsho	6384	14	the	the	DT
cord-006229-7yoilsho	6384	15	SM	sm	NN
cord-006229-7yoilsho	6384	16	resistance	resistance	NN
cord-006229-7yoilsho	6384	17	,	,	,
cord-006229-7yoilsho	6384	18	pointing	point	VBG
cord-006229-7yoilsho	6384	19	out	out	RP
cord-006229-7yoilsho	6384	20	that	that	IN
cord-006229-7yoilsho	6384	21	it	-PRON-	PRP
cord-006229-7yoilsho	6384	22	is	be	VBZ
cord-006229-7yoilsho	6384	23	a	a	DT
cord-006229-7yoilsho	6384	24	combination	combination	NN
cord-006229-7yoilsho	6384	25	of	of	IN
cord-006229-7yoilsho	6384	26	various	various	JJ
cord-006229-7yoilsho	6384	27	effects	effect	NNS
cord-006229-7yoilsho	6384	28	that	that	WDT
cord-006229-7yoilsho	6384	29	are	be	VBP
cord-006229-7yoilsho	6384	30	involved	involve	VBN
cord-006229-7yoilsho	6384	31	to	to	TO
cord-006229-7yoilsho	6384	32	switch	switch	VB
cord-006229-7yoilsho	6384	33	on	on	IN
cord-006229-7yoilsho	6384	34	resistance	resistance	NN
cord-006229-7yoilsho	6384	35	.	.	.
cord-006229-7yoilsho	6385	1	More	more	RBR
cord-006229-7yoilsho	6385	2	likely	likely	JJ
cord-006229-7yoilsho	6385	3	,	,	,
cord-006229-7yoilsho	6385	4	there	there	EX
cord-006229-7yoilsho	6385	5	are	be	VBP
cord-006229-7yoilsho	6385	6	many	many	JJ
cord-006229-7yoilsho	6385	7	aspects	aspect	NNS
cord-006229-7yoilsho	6385	8	working	work	VBG
cord-006229-7yoilsho	6385	9	together	together	RB
cord-006229-7yoilsho	6385	10	.	.	.
cord-006229-7yoilsho	6386	1	The	the	DT
cord-006229-7yoilsho	6386	2	present	present	JJ
cord-006229-7yoilsho	6386	3	results	result	NNS
cord-006229-7yoilsho	6386	4	are	be	VBP
cord-006229-7yoilsho	6386	5	an	an	DT
cord-006229-7yoilsho	6386	6	important	important	JJ
cord-006229-7yoilsho	6386	7	step	step	NN
cord-006229-7yoilsho	6386	8	in	in	IN
cord-006229-7yoilsho	6386	9	the	the	DT
cord-006229-7yoilsho	6386	10	characterization	characterization	NN
cord-006229-7yoilsho	6386	11	of	of	IN
cord-006229-7yoilsho	6386	12	the	the	DT
cord-006229-7yoilsho	6386	13	SM	sm	NN
cord-006229-7yoilsho	6386	14	-	-	HYPH
cord-006229-7yoilsho	6386	15	resistant	resistant	JJ
cord-006229-7yoilsho	6386	16	cell	cell	NN
cord-006229-7yoilsho	6386	17	line	line	NN
cord-006229-7yoilsho	6386	18	and	and	CC
cord-006229-7yoilsho	6386	19	further	further	JJ
cord-006229-7yoilsho	6386	20	studies	study	NNS
cord-006229-7yoilsho	6386	21	may	may	MD
cord-006229-7yoilsho	6386	22	be	be	VB
cord-006229-7yoilsho	6386	23	able	able	JJ
cord-006229-7yoilsho	6386	24	to	to	TO
cord-006229-7yoilsho	6386	25	directly	directly	RB
cord-006229-7yoilsho	6386	26	use	use	VB
cord-006229-7yoilsho	6386	27	these	these	DT
cord-006229-7yoilsho	6386	28	as	as	IN
cord-006229-7yoilsho	6386	29	a	a	DT
cord-006229-7yoilsho	6386	30	start	start	NN
cord-006229-7yoilsho	6386	31	for	for	IN
cord-006229-7yoilsho	6386	32	target	target	NN
cord-006229-7yoilsho	6386	33	identification	identification	NN
cord-006229-7yoilsho	6386	34	in	in	IN
cord-006229-7yoilsho	6386	35	antidote	antidote	NN
cord-006229-7yoilsho	6386	36	or	or	CC
cord-006229-7yoilsho	6386	37	prophylactic	prophylactic	JJ
cord-006229-7yoilsho	6386	38	agent	agent	NN
cord-006229-7yoilsho	6386	39	discovery	discovery	NN
cord-006229-7yoilsho	6386	40	.	.	.
cord-006229-7yoilsho	6387	1	The	the	DT
cord-006229-7yoilsho	6387	2	arylhydrocarbon	arylhydrocarbon	NN
cord-006229-7yoilsho	6387	3	receptor	receptor	NN
cord-006229-7yoilsho	6387	4	(	(	-LRB-
cord-006229-7yoilsho	6387	5	AhR	AhR	NNP
cord-006229-7yoilsho	6387	6	)	)	-RRB-
cord-006229-7yoilsho	6387	7	is	be	VBZ
cord-006229-7yoilsho	6387	8	localized	localize	VBN
cord-006229-7yoilsho	6387	9	in	in	IN
cord-006229-7yoilsho	6387	10	a	a	DT
cord-006229-7yoilsho	6387	11	cytosolic	cytosolic	JJ
cord-006229-7yoilsho	6387	12	complex	complex	NN
cord-006229-7yoilsho	6387	13	that	that	WDT
cord-006229-7yoilsho	6387	14	contains	contain	VBZ
cord-006229-7yoilsho	6387	15	several	several	JJ
cord-006229-7yoilsho	6387	16	co	co	NNS
cord-006229-7yoilsho	6387	17	-	-	NNS
cord-006229-7yoilsho	6387	18	chaperones	chaperone	NNS
cord-006229-7yoilsho	6387	19	and	and	CC
cord-006229-7yoilsho	6387	20	associated	associated	JJ
cord-006229-7yoilsho	6387	21	factors	factor	NNS
cord-006229-7yoilsho	6387	22	.	.	.
cord-006229-7yoilsho	6388	1	The	the	DT
cord-006229-7yoilsho	6388	2	protein	protein	NN
cord-006229-7yoilsho	6388	3	is	be	VBZ
cord-006229-7yoilsho	6388	4	shifted	shift	VBN
cord-006229-7yoilsho	6388	5	into	into	IN
cord-006229-7yoilsho	6388	6	the	the	DT
cord-006229-7yoilsho	6388	7	nucleus	nucleus	NN
cord-006229-7yoilsho	6388	8	in	in	IN
cord-006229-7yoilsho	6388	9	response	response	NN
cord-006229-7yoilsho	6388	10	to	to	IN
cord-006229-7yoilsho	6388	11	endogenous	endogenous	JJ
cord-006229-7yoilsho	6388	12	and	and	CC
cord-006229-7yoilsho	6388	13	xenobiotic	xenobiotic	JJ
cord-006229-7yoilsho	6388	14	ligands	ligand	NNS
cord-006229-7yoilsho	6388	15	.	.	.
cord-006229-7yoilsho	6389	1	However	however	RB
cord-006229-7yoilsho	6389	2	,	,	,
cord-006229-7yoilsho	6389	3	a	a	DT
cord-006229-7yoilsho	6389	4	transient	transient	JJ
cord-006229-7yoilsho	6389	5	nuclear	nuclear	JJ
cord-006229-7yoilsho	6389	6	transport	transport	NN
cord-006229-7yoilsho	6389	7	does	do	VBZ
cord-006229-7yoilsho	6389	8	also	also	RB
cord-006229-7yoilsho	6389	9	occur	occur	VB
cord-006229-7yoilsho	6389	10	in	in	IN
cord-006229-7yoilsho	6389	11	the	the	DT
cord-006229-7yoilsho	6389	12	absence	absence	NN
cord-006229-7yoilsho	6389	13	of	of	IN
cord-006229-7yoilsho	6389	14	any	any	DT
cord-006229-7yoilsho	6389	15	ligands	ligand	NNS
cord-006229-7yoilsho	6389	16	,	,	,
cord-006229-7yoilsho	6389	17	while	while	IN
cord-006229-7yoilsho	6389	18	the	the	DT
cord-006229-7yoilsho	6389	19	predominant	predominant	JJ
cord-006229-7yoilsho	6389	20	cytoplasmic	cytoplasmic	JJ
cord-006229-7yoilsho	6389	21	compartmentalization	compartmentalization	NN
cord-006229-7yoilsho	6389	22	is	be	VBZ
cord-006229-7yoilsho	6389	23	maintained	maintain	VBN
cord-006229-7yoilsho	6389	24	by	by	IN
cord-006229-7yoilsho	6389	25	parallel	parallel	JJ
cord-006229-7yoilsho	6389	26	export	export	NN
cord-006229-7yoilsho	6389	27	.	.	.
cord-006229-7yoilsho	6390	1	We	-PRON-	PRP
cord-006229-7yoilsho	6390	2	have	have	VBP
cord-006229-7yoilsho	6390	3	analyzed	analyze	VBN
cord-006229-7yoilsho	6390	4	the	the	DT
cord-006229-7yoilsho	6390	5	interplay	interplay	NN
cord-006229-7yoilsho	6390	6	between	between	IN
cord-006229-7yoilsho	6390	7	this	this	DT
cord-006229-7yoilsho	6390	8	basal	basal	JJ
cord-006229-7yoilsho	6390	9	nucleo	nucleo	JJ
cord-006229-7yoilsho	6390	10	-	-	JJ
cord-006229-7yoilsho	6390	11	cytoplasmic	cytoplasmic	JJ
cord-006229-7yoilsho	6390	12	shuttling	shuttling	NN
cord-006229-7yoilsho	6390	13	and	and	CC
cord-006229-7yoilsho	6390	14	ligand	ligand	NN
cord-006229-7yoilsho	6390	15	induced	induce	VBN
cord-006229-7yoilsho	6390	16	transport	transport	NN
cord-006229-7yoilsho	6390	17	in	in	IN
cord-006229-7yoilsho	6390	18	HepG2	HepG2	NNP
cord-006229-7yoilsho	6390	19	cells	cell	NNS
cord-006229-7yoilsho	6390	20	,	,	,
cord-006229-7yoilsho	6390	21	using	use	VBG
cord-006229-7yoilsho	6390	22	a	a	DT
cord-006229-7yoilsho	6390	23	YFP	YFP	NNP
cord-006229-7yoilsho	6390	24	-	-	HYPH
cord-006229-7yoilsho	6390	25	tagged	tag	VBN
cord-006229-7yoilsho	6390	26	fusion	fusion	NN
cord-006229-7yoilsho	6390	27	protein	protein	NN
cord-006229-7yoilsho	6390	28	that	that	WDT
cord-006229-7yoilsho	6390	29	is	be	VBZ
cord-006229-7yoilsho	6390	30	capable	capable	JJ
cord-006229-7yoilsho	6390	31	to	to	TO
cord-006229-7yoilsho	6390	32	respond	respond	VB
cord-006229-7yoilsho	6390	33	to	to	IN
cord-006229-7yoilsho	6390	34	ligands	ligand	NNS
cord-006229-7yoilsho	6390	35	and	and	CC
cord-006229-7yoilsho	6390	36	to	to	TO
cord-006229-7yoilsho	6390	37	trigger	trigger	VB
cord-006229-7yoilsho	6390	38	the	the	DT
cord-006229-7yoilsho	6390	39	induction	induction	NN
cord-006229-7yoilsho	6390	40	of	of	IN
cord-006229-7yoilsho	6390	41	CYP1A1	cyp1a1	DT
cord-006229-7yoilsho	6390	42	expression	expression	NN
cord-006229-7yoilsho	6390	43	.	.	.
cord-006229-7yoilsho	6391	1	Basal	basal	NN
cord-006229-7yoilsho	6391	2	import	import	NN
cord-006229-7yoilsho	6391	3	was	be	VBD
cord-006229-7yoilsho	6391	4	assessed	assess	VBN
cord-006229-7yoilsho	6391	5	in	in	IN
cord-006229-7yoilsho	6391	6	cells	cell	NNS
cord-006229-7yoilsho	6391	7	that	that	WDT
cord-006229-7yoilsho	6391	8	had	have	VBD
cord-006229-7yoilsho	6391	9	been	be	VBN
cord-006229-7yoilsho	6391	10	treated	treat	VBN
cord-006229-7yoilsho	6391	11	with	with	IN
cord-006229-7yoilsho	6391	12	leptomycin	leptomycin	NNS
cord-006229-7yoilsho	6391	13	B	B	NNP
cord-006229-7yoilsho	6391	14	(	(	-LRB-
cord-006229-7yoilsho	6391	15	LMB	LMB	NNP
cord-006229-7yoilsho	6391	16	)	)	-RRB-
cord-006229-7yoilsho	6391	17	,	,	,
cord-006229-7yoilsho	6391	18	an	an	DT
cord-006229-7yoilsho	6391	19	inhibitor	inhibitor	NN
cord-006229-7yoilsho	6391	20	of	of	IN
cord-006229-7yoilsho	6391	21	crm1-mediated	crm1-mediated	NNP
cord-006229-7yoilsho	6391	22	nuclear	nuclear	JJ
cord-006229-7yoilsho	6391	23	export	export	NN
cord-006229-7yoilsho	6391	24	.	.	.
cord-006229-7yoilsho	6392	1	Interestingly	interestingly	RB
cord-006229-7yoilsho	6392	2	,	,	,
cord-006229-7yoilsho	6392	3	the	the	DT
cord-006229-7yoilsho	6392	4	apparent	apparent	JJ
cord-006229-7yoilsho	6392	5	AhR	ahr	JJ
cord-006229-7yoilsho	6392	6	import	import	NN
cord-006229-7yoilsho	6392	7	rate	rate	NN
cord-006229-7yoilsho	6392	8	in	in	IN
cord-006229-7yoilsho	6392	9	LMB	LMB	NNP
cord-006229-7yoilsho	6392	10	-	-	HYPH
cord-006229-7yoilsho	6392	11	treated	treat	VBN
cord-006229-7yoilsho	6392	12	cells	cell	NNS
cord-006229-7yoilsho	6392	13	was	be	VBD
cord-006229-7yoilsho	6392	14	comparable	comparable	JJ
cord-006229-7yoilsho	6392	15	with	with	IN
cord-006229-7yoilsho	6392	16	nuclear	nuclear	JJ
cord-006229-7yoilsho	6392	17	import	import	NN
cord-006229-7yoilsho	6392	18	as	as	IN
cord-006229-7yoilsho	6392	19	trigged	trig	VBN
cord-006229-7yoilsho	6392	20	by	by	IN
cord-006229-7yoilsho	6392	21	xenobiotic	xenobiotic	NNP
cord-006229-7yoilsho	6392	22	(	(	-LRB-
cord-006229-7yoilsho	6392	23	b	b	NN
cord-006229-7yoilsho	6392	24	-	-	HYPH
cord-006229-7yoilsho	6392	25	naphthoflavone	naphthoflavone	NN
cord-006229-7yoilsho	6392	26	)	)	-RRB-
cord-006229-7yoilsho	6392	27	or	or	CC
cord-006229-7yoilsho	6392	28	endogenous	endogenous	JJ
cord-006229-7yoilsho	6392	29	(	(	-LRB-
cord-006229-7yoilsho	6392	30	kynurenine	kynurenine	NN
cord-006229-7yoilsho	6392	31	)	)	-RRB-
cord-006229-7yoilsho	6392	32	ligands	ligand	NNS
cord-006229-7yoilsho	6392	33	.	.	.
cord-006229-7yoilsho	6393	1	This	this	DT
cord-006229-7yoilsho	6393	2	observation	observation	NN
cord-006229-7yoilsho	6393	3	was	be	VBD
cord-006229-7yoilsho	6393	4	confirmed	confirm	VBN
cord-006229-7yoilsho	6393	5	for	for	IN
cord-006229-7yoilsho	6393	6	endogenous	endogenous	JJ
cord-006229-7yoilsho	6393	7	AhR	ahr	NN
cord-006229-7yoilsho	6393	8	in	in	IN
cord-006229-7yoilsho	6393	9	HepG2	HepG2	NNP
cord-006229-7yoilsho	6393	10	cells	cell	NNS
cord-006229-7yoilsho	6393	11	,	,	,
cord-006229-7yoilsho	6393	12	since	since	IN
cord-006229-7yoilsho	6393	13	both	both	DT
cord-006229-7yoilsho	6393	14	ligands	ligand	NNS
cord-006229-7yoilsho	6393	15	and	and	CC
cord-006229-7yoilsho	6393	16	LMB	LMB	NNP
cord-006229-7yoilsho	6393	17	showed	show	VBD
cord-006229-7yoilsho	6393	18	comparable	comparable	JJ
cord-006229-7yoilsho	6393	19	effects	effect	NNS
cord-006229-7yoilsho	6393	20	on	on	IN
cord-006229-7yoilsho	6393	21	nuclear	nuclear	JJ
cord-006229-7yoilsho	6393	22	compartmentalization	compartmentalization	NN
cord-006229-7yoilsho	6393	23	.	.	.
cord-006229-7yoilsho	6394	1	However	however	RB
cord-006229-7yoilsho	6394	2	,	,	,
cord-006229-7yoilsho	6394	3	the	the	DT
cord-006229-7yoilsho	6394	4	basal	basal	NN
cord-006229-7yoilsho	6394	5	nuclear	nuclear	JJ
cord-006229-7yoilsho	6394	6	import	import	NN
cord-006229-7yoilsho	6394	7	rate	rate	NN
cord-006229-7yoilsho	6394	8	in	in	IN
cord-006229-7yoilsho	6394	9	LMB	LMB	NNP
cord-006229-7yoilsho	6394	10	-	-	HYPH
cord-006229-7yoilsho	6394	11	treated	treat	VBN
cord-006229-7yoilsho	6394	12	cells	cell	NNS
cord-006229-7yoilsho	6394	13	was	be	VBD
cord-006229-7yoilsho	6394	14	strongly	strongly	RB
cord-006229-7yoilsho	6394	15	increased	increase	VBN
cord-006229-7yoilsho	6394	16	by	by	IN
cord-006229-7yoilsho	6394	17	AhR	ahr	JJ
cord-006229-7yoilsho	6394	18	ligands	ligand	NNS
cord-006229-7yoilsho	6394	19	.	.	.
cord-006229-7yoilsho	6395	1	Ligand	ligand	NN
cord-006229-7yoilsho	6395	2	-	-	HYPH
cord-006229-7yoilsho	6395	3	induced	induce	VBN
cord-006229-7yoilsho	6395	4	nuclear	nuclear	JJ
cord-006229-7yoilsho	6395	5	transport	transport	NN
cord-006229-7yoilsho	6395	6	was	be	VBD
cord-006229-7yoilsho	6395	7	therefore	therefore	RB
cord-006229-7yoilsho	6395	8	confirmed	confirm	VBN
cord-006229-7yoilsho	6395	9	as	as	IN
cord-006229-7yoilsho	6395	10	an	an	DT
cord-006229-7yoilsho	6395	11	import	import	NN
cord-006229-7yoilsho	6395	12	step	step	NN
cord-006229-7yoilsho	6395	13	in	in	IN
cord-006229-7yoilsho	6395	14	receptor	receptor	NN
cord-006229-7yoilsho	6395	15	activation	activation	NN
cord-006229-7yoilsho	6395	16	.	.	.
cord-006229-7yoilsho	6396	1	Interestingly	interestingly	RB
cord-006229-7yoilsho	6396	2	,	,	,
cord-006229-7yoilsho	6396	3	LMB	LMB	NNP
cord-006229-7yoilsho	6396	4	did	do	VBD
cord-006229-7yoilsho	6396	5	also	also	RB
cord-006229-7yoilsho	6396	6	accelerate	accelerate	VB
cord-006229-7yoilsho	6396	7	nuclear	nuclear	JJ
cord-006229-7yoilsho	6396	8	import	import	NN
cord-006229-7yoilsho	6396	9	of	of	IN
cord-006229-7yoilsho	6396	10	AhR	ahr	NN
cord-006229-7yoilsho	6396	11	after	after	IN
cord-006229-7yoilsho	6396	12	pretreatment	pretreatment	NN
cord-006229-7yoilsho	6396	13	of	of	IN
cord-006229-7yoilsho	6396	14	cells	cell	NNS
cord-006229-7yoilsho	6396	15	with	with	IN
cord-006229-7yoilsho	6396	16	AhR	ahr	JJ
cord-006229-7yoilsho	6396	17	ligands	ligand	NNS
cord-006229-7yoilsho	6396	18	.	.	.
cord-006229-7yoilsho	6397	1	These	these	DT
cord-006229-7yoilsho	6397	2	data	datum	NNS
cord-006229-7yoilsho	6397	3	suggest	suggest	VBP
cord-006229-7yoilsho	6397	4	that	that	IN
cord-006229-7yoilsho	6397	5	nuclear	nuclear	JJ
cord-006229-7yoilsho	6397	6	export	export	NN
cord-006229-7yoilsho	6397	7	of	of	IN
cord-006229-7yoilsho	6397	8	the	the	DT
cord-006229-7yoilsho	6397	9	AhR	ahr	NN
cord-006229-7yoilsho	6397	10	is	be	VBZ
cord-006229-7yoilsho	6397	11	maintained	maintain	VBN
cord-006229-7yoilsho	6397	12	in	in	IN
cord-006229-7yoilsho	6397	13	the	the	DT
cord-006229-7yoilsho	6397	14	presence	presence	NN
cord-006229-7yoilsho	6397	15	of	of	IN
cord-006229-7yoilsho	6397	16	ligands	ligand	NNS
cord-006229-7yoilsho	6397	17	.	.	.
cord-006229-7yoilsho	6398	1	Receptor	receptor	NN
cord-006229-7yoilsho	6398	2	activation	activation	NN
cord-006229-7yoilsho	6398	3	might	may	MD
cord-006229-7yoilsho	6398	4	therefore	therefore	RB
cord-006229-7yoilsho	6398	5	comprise	comprise	VB
cord-006229-7yoilsho	6398	6	several	several	JJ
cord-006229-7yoilsho	6398	7	rounds	round	NNS
cord-006229-7yoilsho	6398	8	of	of	IN
cord-006229-7yoilsho	6398	9	shuttling	shuttling	NN
cord-006229-7yoilsho	6398	10	,	,	,
cord-006229-7yoilsho	6398	11	thereby	thereby	RB
cord-006229-7yoilsho	6398	12	involving	involve	VBG
cord-006229-7yoilsho	6398	13	both	both	CC
cord-006229-7yoilsho	6398	14	accelerated	accelerate	VBN
cord-006229-7yoilsho	6398	15	import	import	NN
cord-006229-7yoilsho	6398	16	and	and	CC
cord-006229-7yoilsho	6398	17	continued	continued	JJ
cord-006229-7yoilsho	6398	18	export	export	NN
cord-006229-7yoilsho	6398	19	of	of	IN
cord-006229-7yoilsho	6398	20	the	the	DT
cord-006229-7yoilsho	6398	21	AhR	AhR	NNP
cord-006229-7yoilsho	6398	22	protein	protein	NNP
cord-006229-7yoilsho	6398	23	fraction	fraction	NN
cord-006229-7yoilsho	6398	24	that	that	WDT
cord-006229-7yoilsho	6398	25	has	have	VBZ
cord-006229-7yoilsho	6398	26	not	not	RB
cord-006229-7yoilsho	6398	27	already	already	RB
cord-006229-7yoilsho	6398	28	undergone	undergo	VBN
cord-006229-7yoilsho	6398	29	interactions	interaction	NNS
cord-006229-7yoilsho	6398	30	with	with	IN
cord-006229-7yoilsho	6398	31	ARNT	ARNT	NNPS
cord-006229-7yoilsho	6398	32	or	or	CC
cord-006229-7yoilsho	6398	33	DNA	dna	NN
cord-006229-7yoilsho	6398	34	.	.	.
cord-006229-7yoilsho	6399	1	We	-PRON-	PRP
cord-006229-7yoilsho	6399	2	suggest	suggest	VBP
cord-006229-7yoilsho	6399	3	that	that	IN
cord-006229-7yoilsho	6399	4	nuclear	nuclear	JJ
cord-006229-7yoilsho	6399	5	export	export	NN
cord-006229-7yoilsho	6399	6	provides	provide	VBZ
cord-006229-7yoilsho	6399	7	an	an	DT
cord-006229-7yoilsho	6399	8	additional	additional	JJ
cord-006229-7yoilsho	6399	9	kinetic	kinetic	JJ
cord-006229-7yoilsho	6399	10	control	control	NN
cord-006229-7yoilsho	6399	11	of	of	IN
cord-006229-7yoilsho	6399	12	AhR	AhR	NNP
cord-006229-7yoilsho	6399	13	activation	activation	NN
cord-006229-7yoilsho	6399	14	and	and	CC
cord-006229-7yoilsho	6399	15	function	function	NN
cord-006229-7yoilsho	6399	16	.	.	.
cord-006229-7yoilsho	6400	1	Mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	6400	2	Toxicology	Toxicology	NNP
cord-006229-7yoilsho	6400	3	:	:	:
cord-006229-7yoilsho	6400	4	Rescuing	rescue	VBG
cord-006229-7yoilsho	6400	5	mitochondria	mitochondrion	NNS
cord-006229-7yoilsho	6400	6	in	in	IN
cord-006229-7yoilsho	6400	7	Wilson	Wilson	NNP
cord-006229-7yoilsho	6400	8	disease	disease	NN
cord-006229-7yoilsho	6400	9	avoids	avoid	VBZ
cord-006229-7yoilsho	6400	10	acute	acute	JJ
cord-006229-7yoilsho	6400	11	liver	liver	NN
cord-006229-7yoilsho	6400	12	failure	failure	NN
cord-006229-7yoilsho	6400	13	H.	H.	NNP
cord-006229-7yoilsho	6400	14	Zischka	Zischka	NNP
cord-006229-7yoilsho	6400	15	1	1	CD
cord-006229-7yoilsho	6400	16	1	1	CD
cord-006229-7yoilsho	6400	17	Institut	Institut	NNP
cord-006229-7yoilsho	6400	18	für	für	IN
cord-006229-7yoilsho	6400	19	molekulare	molekulare	NN
cord-006229-7yoilsho	6400	20	Toxikologie	Toxikologie	NNP
cord-006229-7yoilsho	6400	21	und	und	IN
cord-006229-7yoilsho	6400	22	Pharmakologie	Pharmakologie	NNP
cord-006229-7yoilsho	6400	23	,	,	,
cord-006229-7yoilsho	6400	24	AG	AG	NNP
cord-006229-7yoilsho	6400	25	Zischka	Zischka	NNP
cord-006229-7yoilsho	6400	26	,	,	,
cord-006229-7yoilsho	6400	27	Neuherberg	Neuherberg	NNP
cord-006229-7yoilsho	6400	28	,	,	,
cord-006229-7yoilsho	6400	29	Germany	Germany	NNP
cord-006229-7yoilsho	6401	1	In	in	IN
cord-006229-7yoilsho	6401	2	Wilson	Wilson	NNP
cord-006229-7yoilsho	6401	3	disease	disease	NN
cord-006229-7yoilsho	6401	4	(	(	-LRB-
cord-006229-7yoilsho	6401	5	WD	WD	NNP
cord-006229-7yoilsho	6401	6	)	)	-RRB-
cord-006229-7yoilsho	6401	7	functional	functional	JJ
cord-006229-7yoilsho	6401	8	loss	loss	NN
cord-006229-7yoilsho	6401	9	mutations	mutation	NNS
cord-006229-7yoilsho	6401	10	in	in	IN
cord-006229-7yoilsho	6401	11	the	the	DT
cord-006229-7yoilsho	6401	12	hepatocyte	hepatocyte	NN
cord-006229-7yoilsho	6401	13	ATP7B	atp7b	NN
cord-006229-7yoilsho	6401	14	gene	gene	NN
cord-006229-7yoilsho	6401	15	cause	cause	VBP
cord-006229-7yoilsho	6401	16	dramatic	dramatic	JJ
cord-006229-7yoilsho	6401	17	copper	copper	NN
cord-006229-7yoilsho	6401	18	overload	overload	NN
cord-006229-7yoilsho	6401	19	leading	lead	VBG
cord-006229-7yoilsho	6401	20	to	to	IN
cord-006229-7yoilsho	6401	21	acute	acute	JJ
cord-006229-7yoilsho	6401	22	liver	liver	NN
cord-006229-7yoilsho	6401	23	failure	failure	NN
cord-006229-7yoilsho	6401	24	,	,	,
cord-006229-7yoilsho	6401	25	posing	pose	VBG
cord-006229-7yoilsho	6401	26	an	an	DT
cord-006229-7yoilsho	6401	27	unmet	unmet	JJ
cord-006229-7yoilsho	6401	28	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	6401	29	issue	issue	NN
cord-006229-7yoilsho	6401	30	.	.	.
cord-006229-7yoilsho	6402	1	We	-PRON-	PRP
cord-006229-7yoilsho	6402	2	find	find	VBP
cord-006229-7yoilsho	6402	3	that	that	IN
cord-006229-7yoilsho	6402	4	the	the	DT
cord-006229-7yoilsho	6402	5	pathology	pathology	NN
cord-006229-7yoilsho	6402	6	of	of	IN
cord-006229-7yoilsho	6402	7	severe	severe	JJ
cord-006229-7yoilsho	6402	8	WD	WD	NNP
cord-006229-7yoilsho	6402	9	cases	case	NNS
cord-006229-7yoilsho	6402	10	is	be	VBZ
cord-006229-7yoilsho	6402	11	mirrored	mirror	VBN
cord-006229-7yoilsho	6402	12	in	in	IN
cord-006229-7yoilsho	6402	13	LPP	LPP	NNP
cord-006229-7yoilsho	6402	14	(	(	-LRB-
cord-006229-7yoilsho	6402	15	-/-	-/-	NNP
cord-006229-7yoilsho	6402	16	)	)	-RRB-
cord-006229-7yoilsho	6402	17	rats	rat	NNS
cord-006229-7yoilsho	6402	18	carrying	carry	VBG
cord-006229-7yoilsho	6402	19	a	a	DT
cord-006229-7yoilsho	6402	20	functional	functional	JJ
cord-006229-7yoilsho	6402	21	loss	loss	NN
cord-006229-7yoilsho	6402	22	Atp7b	Atp7b	NNP
cord-006229-7yoilsho	6402	23	mutation	mutation	NN
cord-006229-7yoilsho	6402	24	.	.	.
cord-006229-7yoilsho	6403	1	This	this	DT
cord-006229-7yoilsho	6403	2	is	be	VBZ
cord-006229-7yoilsho	6403	3	especially	especially	RB
cord-006229-7yoilsho	6403	4	apparent	apparent	JJ
cord-006229-7yoilsho	6403	5	in	in	IN
cord-006229-7yoilsho	6403	6	the	the	DT
cord-006229-7yoilsho	6403	7	hepatocyte	hepatocyte	NN
cord-006229-7yoilsho	6403	8	mitochondrial	mitochondrial	NN
cord-006229-7yoilsho	6403	9	compartment	compartment	NN
cord-006229-7yoilsho	6403	10	.	.	.
cord-006229-7yoilsho	6404	1	A	a	DT
cord-006229-7yoilsho	6404	2	progressive	progressive	JJ
cord-006229-7yoilsho	6404	3	copper	copper	NN
cord-006229-7yoilsho	6404	4	deposition	deposition	NN
cord-006229-7yoilsho	6404	5	increasingly	increasingly	RB
cord-006229-7yoilsho	6404	6	harms	harm	VBZ
cord-006229-7yoilsho	6404	7	the	the	DT
cord-006229-7yoilsho	6404	8	lifesustaining	lifesustaine	VBG
cord-006229-7yoilsho	6404	9	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	6404	10	membrane	membrane	NN
cord-006229-7yoilsho	6404	11	integrity	integrity	NN
cord-006229-7yoilsho	6404	12	.	.	.
cord-006229-7yoilsho	6405	1	Thus	thus	RB
cord-006229-7yoilsho	6405	2	,	,	,
cord-006229-7yoilsho	6405	3	depleting	deplete	VBG
cord-006229-7yoilsho	6405	4	this	this	DT
cord-006229-7yoilsho	6405	5	devastating	devastating	JJ
cord-006229-7yoilsho	6405	6	mitochondrial	mitochondrial	JJ
cord-006229-7yoilsho	6405	7	copper	copper	NN
cord-006229-7yoilsho	6405	8	burden	burden	NN
cord-006229-7yoilsho	6405	9	is	be	VBZ
cord-006229-7yoilsho	6405	10	a	a	DT
cord-006229-7yoilsho	6405	11	core	core	NN
cord-006229-7yoilsho	6405	12	requirement	requirement	NN
cord-006229-7yoilsho	6405	13	for	for	IN
cord-006229-7yoilsho	6405	14	a	a	DT
cord-006229-7yoilsho	6405	15	treatment	treatment	NN
cord-006229-7yoilsho	6405	16	strategy	strategy	NN
cord-006229-7yoilsho	6405	17	against	against	IN
cord-006229-7yoilsho	6405	18	acute	acute	JJ
cord-006229-7yoilsho	6405	19	liver	liver	NN
cord-006229-7yoilsho	6405	20	failure	failure	NN
cord-006229-7yoilsho	6405	21	in	in	IN
cord-006229-7yoilsho	6405	22	this	this	DT
cord-006229-7yoilsho	6405	23	WD	WD	NNP
cord-006229-7yoilsho	6405	24	animal	animal	NN
cord-006229-7yoilsho	6405	25	model	model	NN
cord-006229-7yoilsho	6405	26	.	.	.
cord-006229-7yoilsho	6406	1	Preparation	preparation	NN
cord-006229-7yoilsho	6406	2	for	for	IN
cord-006229-7yoilsho	6406	3	the	the	DT
cord-006229-7yoilsho	6406	4	master	master	NN
cord-006229-7yoilsho	6406	5	degree	degree	NN
cord-006229-7yoilsho	6406	6	program	program	NN
cord-006229-7yoilsho	6406	7	in	in	IN
cord-006229-7yoilsho	6406	8	toxicology	toxicology	NN
cord-006229-7yoilsho	6406	9	started	start	VBD
cord-006229-7yoilsho	6406	10	in	in	IN
cord-006229-7yoilsho	6406	11	2006	2006	CD
cord-006229-7yoilsho	6406	12	as	as	IN
cord-006229-7yoilsho	6406	13	a	a	DT
cord-006229-7yoilsho	6406	14	cooperation	cooperation	NN
cord-006229-7yoilsho	6406	15	of	of	IN
cord-006229-7yoilsho	6406	16	Charité	Charité	NNP
cord-006229-7yoilsho	6406	17	Universitätsmedizin	Universitätsmedizin	NNP
cord-006229-7yoilsho	6406	18	Berlin	Berlin	NNP
cord-006229-7yoilsho	6406	19	with	with	IN
cord-006229-7yoilsho	6406	20	the	the	DT
cord-006229-7yoilsho	6406	21	University	University	NNP
cord-006229-7yoilsho	6406	22	of	of	IN
cord-006229-7yoilsho	6406	23	Potsdam	Potsdam	NNP
cord-006229-7yoilsho	6406	24	and	and	CC
cord-006229-7yoilsho	6406	25	other	other	JJ
cord-006229-7yoilsho	6406	26	institutions	institution	NNS
cord-006229-7yoilsho	6406	27	of	of	IN
cord-006229-7yoilsho	6406	28	the	the	DT
cord-006229-7yoilsho	6406	29	region	region	NN
cord-006229-7yoilsho	6406	30	.	.	.
cord-006229-7yoilsho	6407	1	First	first	JJ
cord-006229-7yoilsho	6407	2	enrollment	enrollment	NN
cord-006229-7yoilsho	6407	3	of	of	IN
cord-006229-7yoilsho	6407	4	students	student	NNS
cord-006229-7yoilsho	6407	5	was	be	VBD
cord-006229-7yoilsho	6407	6	done	do	VBN
cord-006229-7yoilsho	6407	7	in	in	IN
cord-006229-7yoilsho	6407	8	2008	2008	CD
cord-006229-7yoilsho	6407	9	.	.	.
cord-006229-7yoilsho	6408	1	The	the	DT
cord-006229-7yoilsho	6408	2	program	program	NN
cord-006229-7yoilsho	6408	3	was	be	VBD
cord-006229-7yoilsho	6408	4	accredited	accredit	VBN
cord-006229-7yoilsho	6408	5	in	in	IN
cord-006229-7yoilsho	6408	6	2011	2011	CD
cord-006229-7yoilsho	6408	7	by	by	IN
cord-006229-7yoilsho	6408	8	the	the	DT
cord-006229-7yoilsho	6408	9	Central	Central	NNP
cord-006229-7yoilsho	6408	10	Evaluation	Evaluation	NNP
cord-006229-7yoilsho	6408	11	and	and	CC
cord-006229-7yoilsho	6408	12	Accreditation	Accreditation	NNP
cord-006229-7yoilsho	6408	13	Agency	Agency	NNP
cord-006229-7yoilsho	6408	14	.	.	.
cord-006229-7yoilsho	6409	1	It	-PRON-	PRP
cord-006229-7yoilsho	6409	2	offers	offer	VBZ
cord-006229-7yoilsho	6409	3	a	a	DT
cord-006229-7yoilsho	6409	4	modern	modern	JJ
cord-006229-7yoilsho	6409	5	curriculum	curriculum	NN
cord-006229-7yoilsho	6409	6	encompassing	encompass	VBG
cord-006229-7yoilsho	6409	7	a	a	DT
cord-006229-7yoilsho	6409	8	wide	wide	JJ
cord-006229-7yoilsho	6409	9	variety	variety	NN
cord-006229-7yoilsho	6409	10	of	of	IN
cord-006229-7yoilsho	6409	11	scientific	scientific	JJ
cord-006229-7yoilsho	6409	12	aspects	aspect	NNS
cord-006229-7yoilsho	6409	13	with	with	IN
cord-006229-7yoilsho	6409	14	an	an	DT
cord-006229-7yoilsho	6409	15	interdisciplinary	interdisciplinary	JJ
cord-006229-7yoilsho	6409	16	character	character	NN
cord-006229-7yoilsho	6409	17	.	.	.
cord-006229-7yoilsho	6410	1	This	this	DT
cord-006229-7yoilsho	6410	2	training	training	NN
cord-006229-7yoilsho	6410	3	program	program	NN
cord-006229-7yoilsho	6410	4	in	in	IN
cord-006229-7yoilsho	6410	5	toxicology	toxicology	NN
cord-006229-7yoilsho	6410	6	is	be	VBZ
cord-006229-7yoilsho	6410	7	organized	organize	VBN
cord-006229-7yoilsho	6410	8	in	in	IN
cord-006229-7yoilsho	6410	9	modules	module	NNS
cord-006229-7yoilsho	6410	10	and	and	CC
cord-006229-7yoilsho	6410	11	ends	end	VBZ
cord-006229-7yoilsho	6410	12	with	with	IN
cord-006229-7yoilsho	6410	13	the	the	DT
cord-006229-7yoilsho	6410	14	degree	degree	NN
cord-006229-7yoilsho	6410	15	"	"	``
cord-006229-7yoilsho	6410	16	Master	Master	NNP
cord-006229-7yoilsho	6410	17	of	of	IN
cord-006229-7yoilsho	6410	18	Science	Science	NNP
cord-006229-7yoilsho	6410	19	"	"	''
cord-006229-7yoilsho	6410	20	(	(	-LRB-
cord-006229-7yoilsho	6410	21	M.Sc	M.Sc	NNP
cord-006229-7yoilsho	6410	22	.	.	.
cord-006229-7yoilsho	6410	23	)	)	-RRB-
cord-006229-7yoilsho	6410	24	.	.	.
cord-006229-7yoilsho	6411	1	The	the	DT
cord-006229-7yoilsho	6411	2	goal	goal	NN
cord-006229-7yoilsho	6411	3	of	of	IN
cord-006229-7yoilsho	6411	4	this	this	DT
cord-006229-7yoilsho	6411	5	program	program	NN
cord-006229-7yoilsho	6411	6	in	in	IN
cord-006229-7yoilsho	6411	7	toxicology	toxicology	NN
cord-006229-7yoilsho	6411	8	is	be	VBZ
cord-006229-7yoilsho	6411	9	to	to	TO
cord-006229-7yoilsho	6411	10	teach	teach	VB
cord-006229-7yoilsho	6411	11	the	the	DT
cord-006229-7yoilsho	6411	12	basis	basis	NN
cord-006229-7yoilsho	6411	13	of	of	IN
cord-006229-7yoilsho	6411	14	the	the	DT
cord-006229-7yoilsho	6411	15	interactions	interaction	NNS
cord-006229-7yoilsho	6411	16	between	between	IN
cord-006229-7yoilsho	6411	17	substances	substance	NNS
cord-006229-7yoilsho	6411	18	at	at	IN
cord-006229-7yoilsho	6411	19	toxic	toxic	JJ
cord-006229-7yoilsho	6411	20	concentrations	concentration	NNS
cord-006229-7yoilsho	6411	21	and	and	CC
cord-006229-7yoilsho	6411	22	living	live	VBG
cord-006229-7yoilsho	6411	23	organisms	organism	NNS
cord-006229-7yoilsho	6411	24	,	,	,
cord-006229-7yoilsho	6411	25	as	as	RB
cord-006229-7yoilsho	6411	26	well	well	RB
cord-006229-7yoilsho	6411	27	as	as	IN
cord-006229-7yoilsho	6411	28	the	the	DT
cord-006229-7yoilsho	6411	29	molecular	molecular	JJ
cord-006229-7yoilsho	6411	30	mechanism	mechanism	NN
cord-006229-7yoilsho	6411	31	of	of	IN
cord-006229-7yoilsho	6411	32	the	the	DT
cord-006229-7yoilsho	6411	33	adverse	adverse	JJ
cord-006229-7yoilsho	6411	34	effects	effect	NNS
cord-006229-7yoilsho	6411	35	of	of	IN
cord-006229-7yoilsho	6411	36	chemicals	chemical	NNS
cord-006229-7yoilsho	6411	37	.	.	.
cord-006229-7yoilsho	6412	1	The	the	DT
cord-006229-7yoilsho	6412	2	understanding	understanding	NN
cord-006229-7yoilsho	6412	3	of	of	IN
cord-006229-7yoilsho	6412	4	the	the	DT
cord-006229-7yoilsho	6412	5	mechanism	mechanism	NN
cord-006229-7yoilsho	6412	6	of	of	IN
cord-006229-7yoilsho	6412	7	a	a	DT
cord-006229-7yoilsho	6412	8	toxic	toxic	JJ
cord-006229-7yoilsho	6412	9	action	action	NN
cord-006229-7yoilsho	6412	10	is	be	VBZ
cord-006229-7yoilsho	6412	11	an	an	DT
cord-006229-7yoilsho	6412	12	important	important	JJ
cord-006229-7yoilsho	6412	13	prerequisite	prerequisite	NN
cord-006229-7yoilsho	6412	14	for	for	IN
cord-006229-7yoilsho	6412	15	the	the	DT
cord-006229-7yoilsho	6412	16	scientifically	scientifically	RB
cord-006229-7yoilsho	6412	17	based	base	VBN
cord-006229-7yoilsho	6412	18	evaluation	evaluation	NN
cord-006229-7yoilsho	6412	19	of	of	IN
cord-006229-7yoilsho	6412	20	a	a	DT
cord-006229-7yoilsho	6412	21	hazard	hazard	NN
cord-006229-7yoilsho	6412	22	associated	associate	VBN
cord-006229-7yoilsho	6412	23	with	with	IN
cord-006229-7yoilsho	6412	24	a	a	DT
cord-006229-7yoilsho	6412	25	substance	substance	NN
cord-006229-7yoilsho	6412	26	.	.	.
cord-006229-7yoilsho	6413	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	6413	2	,	,	,
cord-006229-7yoilsho	6413	3	only	only	RB
cord-006229-7yoilsho	6413	4	with	with	IN
cord-006229-7yoilsho	6413	5	the	the	DT
cord-006229-7yoilsho	6413	6	knowledge	knowledge	NN
cord-006229-7yoilsho	6413	7	of	of	IN
cord-006229-7yoilsho	6413	8	the	the	DT
cord-006229-7yoilsho	6413	9	mechanism	mechanism	NN
cord-006229-7yoilsho	6413	10	of	of	IN
cord-006229-7yoilsho	6413	11	action	action	NN
cord-006229-7yoilsho	6413	12	and	and	CC
cord-006229-7yoilsho	6413	13	a	a	DT
cord-006229-7yoilsho	6413	14	deduction	deduction	NN
cord-006229-7yoilsho	6413	15	of	of	IN
cord-006229-7yoilsho	6413	16	structure	structure	NN
cord-006229-7yoilsho	6413	17	activity	activity	NN
cord-006229-7yoilsho	6413	18	relationships	relationship	NNS
cord-006229-7yoilsho	6413	19	it	-PRON-	PRP
cord-006229-7yoilsho	6413	20	is	be	VBZ
cord-006229-7yoilsho	6413	21	possible	possible	JJ
cord-006229-7yoilsho	6413	22	to	to	TO
cord-006229-7yoilsho	6413	23	predict	predict	VB
cord-006229-7yoilsho	6413	24	toxic	toxic	JJ
cord-006229-7yoilsho	6413	25	effects	effect	NNS
cord-006229-7yoilsho	6413	26	of	of	IN
cord-006229-7yoilsho	6413	27	new	new	JJ
cord-006229-7yoilsho	6413	28	substances	substance	NNS
cord-006229-7yoilsho	6413	29	.	.	.
cord-006229-7yoilsho	6414	1	This	this	DT
cord-006229-7yoilsho	6414	2	knowledge	knowledge	NN
cord-006229-7yoilsho	6414	3	should	should	MD
cord-006229-7yoilsho	6414	4	enable	enable	VB
cord-006229-7yoilsho	6414	5	students	student	NNS
cord-006229-7yoilsho	6414	6	to	to	TO
cord-006229-7yoilsho	6414	7	perform	perform	VB
cord-006229-7yoilsho	6414	8	a	a	DT
cord-006229-7yoilsho	6414	9	risk	risk	NN
cord-006229-7yoilsho	6414	10	evaluation	evaluation	NN
cord-006229-7yoilsho	6414	11	of	of	IN
cord-006229-7yoilsho	6414	12	chemicals	chemical	NNS
cord-006229-7yoilsho	6414	13	or	or	CC
cord-006229-7yoilsho	6414	14	to	to	TO
cord-006229-7yoilsho	6414	15	predict	predict	VB
cord-006229-7yoilsho	6414	16	the	the	DT
cord-006229-7yoilsho	6414	17	adverse	adverse	JJ
cord-006229-7yoilsho	6414	18	effects	effect	NNS
cord-006229-7yoilsho	6414	19	of	of	IN
cord-006229-7yoilsho	6414	20	chemicals	chemical	NNS
cord-006229-7yoilsho	6414	21	with	with	IN
cord-006229-7yoilsho	6414	22	the	the	DT
cord-006229-7yoilsho	6414	23	aim	aim	NN
cord-006229-7yoilsho	6414	24	that	that	IN
cord-006229-7yoilsho	6414	25	human	human	JJ
cord-006229-7yoilsho	6414	26	beings	being	NNS
cord-006229-7yoilsho	6414	27	and	and	CC
cord-006229-7yoilsho	6414	28	the	the	DT
cord-006229-7yoilsho	6414	29	environment	environment	NN
cord-006229-7yoilsho	6414	30	can	can	MD
cord-006229-7yoilsho	6414	31	be	be	VB
cord-006229-7yoilsho	6414	32	protected	protect	VBN
cord-006229-7yoilsho	6414	33	from	from	IN
cord-006229-7yoilsho	6414	34	harmful	harmful	JJ
cord-006229-7yoilsho	6414	35	consequences	consequence	NNS
cord-006229-7yoilsho	6414	36	of	of	IN
cord-006229-7yoilsho	6414	37	chemical	chemical	JJ
cord-006229-7yoilsho	6414	38	exposure	exposure	NN
cord-006229-7yoilsho	6414	39	.	.	.
cord-006229-7yoilsho	6415	1	The	the	DT
cord-006229-7yoilsho	6415	2	program	program	NN
cord-006229-7yoilsho	6415	3	allocates	allocate	VBZ
cord-006229-7yoilsho	6415	4	30	30	CD
cord-006229-7yoilsho	6415	5	places	place	NNS
cord-006229-7yoilsho	6415	6	per	per	IN
cord-006229-7yoilsho	6415	7	year	year	NN
cord-006229-7yoilsho	6415	8	to	to	IN
cord-006229-7yoilsho	6415	9	an	an	DT
cord-006229-7yoilsho	6415	10	average	average	NN
cord-006229-7yoilsho	6415	11	of	of	IN
cord-006229-7yoilsho	6415	12	60	60	CD
cord-006229-7yoilsho	6415	13	applicants	applicant	NNS
cord-006229-7yoilsho	6415	14	.	.	.
cord-006229-7yoilsho	6416	1	Most	Most	JJS
cord-006229-7yoilsho	6416	2	applicants	applicant	NNS
cord-006229-7yoilsho	6416	3	have	have	VBP
cord-006229-7yoilsho	6416	4	a	a	DT
cord-006229-7yoilsho	6416	5	basic	basic	JJ
cord-006229-7yoilsho	6416	6	training	training	NN
cord-006229-7yoilsho	6416	7	in	in	IN
cord-006229-7yoilsho	6416	8	the	the	DT
cord-006229-7yoilsho	6416	9	fields	field	NNS
cord-006229-7yoilsho	6416	10	biology	biology	NN
cord-006229-7yoilsho	6416	11	,	,	,
cord-006229-7yoilsho	6416	12	chemistry	chemistry	NN
cord-006229-7yoilsho	6416	13	,	,	,
cord-006229-7yoilsho	6416	14	pharmacy	pharmacy	NN
cord-006229-7yoilsho	6416	15	,	,	,
cord-006229-7yoilsho	6416	16	veterinary	veterinary	JJ
cord-006229-7yoilsho	6416	17	medicine	medicine	NN
cord-006229-7yoilsho	6416	18	and	and	CC
cord-006229-7yoilsho	6416	19	nutritional	nutritional	JJ
cord-006229-7yoilsho	6416	20	sciences	science	NNS
cord-006229-7yoilsho	6416	21	.	.	.
cord-006229-7yoilsho	6417	1	About	about	RB
cord-006229-7yoilsho	6417	2	75	75	CD
cord-006229-7yoilsho	6417	3	%	%	NN
cord-006229-7yoilsho	6417	4	of	of	IN
cord-006229-7yoilsho	6417	5	the	the	DT
cord-006229-7yoilsho	6417	6	students	student	NNS
cord-006229-7yoilsho	6417	7	are	be	VBP
cord-006229-7yoilsho	6417	8	female	female	JJ
cord-006229-7yoilsho	6417	9	.	.	.
cord-006229-7yoilsho	6418	1	The	the	DT
cord-006229-7yoilsho	6418	2	majority	majority	NN
cord-006229-7yoilsho	6418	3	of	of	IN
cord-006229-7yoilsho	6418	4	them	-PRON-	PRP
cord-006229-7yoilsho	6418	5	have	have	VBP
cord-006229-7yoilsho	6418	6	a	a	DT
cord-006229-7yoilsho	6418	7	bachelor	bachelor	NN
cord-006229-7yoilsho	6418	8	's	's	POS
cord-006229-7yoilsho	6418	9	degree	degree	NN
cord-006229-7yoilsho	6418	10	before	before	IN
cord-006229-7yoilsho	6418	11	starting	start	VBG
cord-006229-7yoilsho	6418	12	the	the	DT
cord-006229-7yoilsho	6418	13	master	master	NN
cord-006229-7yoilsho	6418	14	program	program	NN
cord-006229-7yoilsho	6418	15	,	,	,
cord-006229-7yoilsho	6418	16	other	other	JJ
cord-006229-7yoilsho	6418	17	degrees	degree	NNS
cord-006229-7yoilsho	6418	18	are	be	VBP
cord-006229-7yoilsho	6418	19	diploma	diploma	NN
cord-006229-7yoilsho	6418	20	and	and	CC
cord-006229-7yoilsho	6418	21	state	state	NN
cord-006229-7yoilsho	6418	22	examination	examination	NN
cord-006229-7yoilsho	6418	23	as	as	IN
cord-006229-7yoilsho	6418	24	pharmacists	pharmacist	NNS
cord-006229-7yoilsho	6418	25	or	or	CC
cord-006229-7yoilsho	6418	26	physicians	physician	NNS
cord-006229-7yoilsho	6418	27	.	.	.
cord-006229-7yoilsho	6419	1	Ninety	ninety	CD
cord-006229-7yoilsho	6419	2	percent	percent	NN
cord-006229-7yoilsho	6419	3	of	of	IN
cord-006229-7yoilsho	6419	4	the	the	DT
cord-006229-7yoilsho	6419	5	students	student	NNS
cord-006229-7yoilsho	6419	6	pass	pass	VBP
cord-006229-7yoilsho	6419	7	the	the	DT
cord-006229-7yoilsho	6419	8	final	final	JJ
cord-006229-7yoilsho	6419	9	examination	examination	NN
cord-006229-7yoilsho	6419	10	consisting	consist	VBG
cord-006229-7yoilsho	6419	11	of	of	IN
cord-006229-7yoilsho	6419	12	the	the	DT
cord-006229-7yoilsho	6419	13	master	master	NN
cord-006229-7yoilsho	6419	14	's	's	POS
cord-006229-7yoilsho	6419	15	thesis	thesis	NN
cord-006229-7yoilsho	6419	16	and	and	CC
cord-006229-7yoilsho	6419	17	disputation	disputation	NN
cord-006229-7yoilsho	6419	18	at	at	IN
cord-006229-7yoilsho	6419	19	the	the	DT
cord-006229-7yoilsho	6419	20	end	end	NN
cord-006229-7yoilsho	6419	21	of	of	IN
cord-006229-7yoilsho	6419	22	the	the	DT
cord-006229-7yoilsho	6419	23	four	four	CD
cord-006229-7yoilsho	6419	24	semesters	semester	NNS
cord-006229-7yoilsho	6419	25	.	.	.
cord-006229-7yoilsho	6420	1	Afterwards	afterwards	RB
cord-006229-7yoilsho	6420	2	,	,	,
cord-006229-7yoilsho	6420	3	most	most	JJS
cord-006229-7yoilsho	6420	4	of	of	IN
cord-006229-7yoilsho	6420	5	the	the	DT
cord-006229-7yoilsho	6420	6	graduates	graduate	NNS
cord-006229-7yoilsho	6420	7	aim	aim	VBP
cord-006229-7yoilsho	6420	8	to	to	TO
cord-006229-7yoilsho	6420	9	obtain	obtain	VB
cord-006229-7yoilsho	6420	10	a	a	DT
cord-006229-7yoilsho	6420	11	PhD	phd	NN
cord-006229-7yoilsho	6420	12	degree	degree	NN
cord-006229-7yoilsho	6420	13	.	.	.
cord-006229-7yoilsho	6421	1	The	the	DT
cord-006229-7yoilsho	6421	2	program	program	NN
cord-006229-7yoilsho	6421	3	is	be	VBZ
cord-006229-7yoilsho	6421	4	well	well	RB
cord-006229-7yoilsho	6421	5	established	establish	VBN
cord-006229-7yoilsho	6421	6	in	in	IN
cord-006229-7yoilsho	6421	7	the	the	DT
cord-006229-7yoilsho	6421	8	education	education	NN
cord-006229-7yoilsho	6421	9	of	of	IN
cord-006229-7yoilsho	6421	10	toxicologists	toxicologist	NNS
cord-006229-7yoilsho	6421	11	in	in	IN
cord-006229-7yoilsho	6421	12	Germany	Germany	NNP
cord-006229-7yoilsho	6421	13	.	.	.
cord-006229-7yoilsho	6422	1	Respiratory	respiratory	JJ
cord-006229-7yoilsho	6422	2	injury	injury	NN
cord-006229-7yoilsho	6422	3	due	due	IN
cord-006229-7yoilsho	6422	4	to	to	IN
cord-006229-7yoilsho	6422	5	chlorine	chlorine	NN
cord-006229-7yoilsho	6422	6	developed	develop	VBN
cord-006229-7yoilsho	6422	7	from	from	IN
cord-006229-7yoilsho	6422	8	consumer	consumer	NN
cord-006229-7yoilsho	6422	9	products	product	NNS
cord-006229-7yoilsho	6422	10	.	.	.
cord-006229-7yoilsho	6423	1	still	still	RB
cord-006229-7yoilsho	6423	2	an	an	DT
cord-006229-7yoilsho	6423	3	issue	issue	NN
cord-006229-7yoilsho	6423	4	in	in	IN
cord-006229-7yoilsho	6423	5	germany	germany	NNP
cord-006229-7yoilsho	6423	6	U.	U.	NNP
cord-006229-7yoilsho	6423	7	Stedtler	Stedtler	NNP
cord-006229-7yoilsho	6423	8	1	1	CD
cord-006229-7yoilsho	6423	9	,	,	,
cord-006229-7yoilsho	6423	10	M.	M.	NNP
cord-006229-7yoilsho	6423	11	Hermanns	Hermanns	NNP
cord-006229-7yoilsho	6423	12	-	-	HYPH
cord-006229-7yoilsho	6423	13	Clausen	Clausen	NNP
cord-006229-7yoilsho	6423	14	1	1	CD
cord-006229-7yoilsho	6423	15	1	1	CD
cord-006229-7yoilsho	6423	16	Uniklinikum	Uniklinikum	NNP
cord-006229-7yoilsho	6423	17	Freiburg	Freiburg	NNP
cord-006229-7yoilsho	6423	18	,	,	,
cord-006229-7yoilsho	6423	19	Vergiftungs	Vergiftungs	NNP
cord-006229-7yoilsho	6423	20	-	-	HYPH
cord-006229-7yoilsho	6423	21	Informations	Informations	NNP
cord-006229-7yoilsho	6423	22	-	-	HYPH
cord-006229-7yoilsho	6423	23	Zentrale	Zentrale	NNP
cord-006229-7yoilsho	6423	24	,	,	,
cord-006229-7yoilsho	6423	25	Freiburg	Freiburg	NNP
cord-006229-7yoilsho	6423	26	,	,	,
cord-006229-7yoilsho	6424	1	Germany	Germany	NNP
cord-006229-7yoilsho	6424	2	Objective	Objective	NNP
cord-006229-7yoilsho	6424	3	:	:	:
cord-006229-7yoilsho	6424	4	In	in	IN
cord-006229-7yoilsho	6424	5	the	the	DT
cord-006229-7yoilsho	6424	6	last	last	JJ
cord-006229-7yoilsho	6424	7	decades	decade	NNS
cord-006229-7yoilsho	6424	8	strong	strong	JJ
cord-006229-7yoilsho	6424	9	effords	efford	NNS
cord-006229-7yoilsho	6424	10	have	have	VBP
cord-006229-7yoilsho	6424	11	been	be	VBN
cord-006229-7yoilsho	6424	12	took	take	VBN
cord-006229-7yoilsho	6424	13	to	to	TO
cord-006229-7yoilsho	6424	14	improve	improve	VB
cord-006229-7yoilsho	6424	15	product	product	NN
cord-006229-7yoilsho	6424	16	safety	safety	NN
cord-006229-7yoilsho	6424	17	,	,	,
cord-006229-7yoilsho	6424	18	especially	especially	RB
cord-006229-7yoilsho	6424	19	in	in	IN
cord-006229-7yoilsho	6424	20	products	product	NNS
cord-006229-7yoilsho	6424	21	intended	intend	VBN
cord-006229-7yoilsho	6424	22	for	for	IN
cord-006229-7yoilsho	6424	23	domestic	domestic	JJ
cord-006229-7yoilsho	6424	24	use	use	NN
cord-006229-7yoilsho	6424	25	.	.	.
cord-006229-7yoilsho	6425	1	Hypochlorite	hypochlorite	NN
cord-006229-7yoilsho	6425	2	-	-	HYPH
cord-006229-7yoilsho	6425	3	containing	contain	VBG
cord-006229-7yoilsho	6425	4	cleaners	cleaner	NNS
cord-006229-7yoilsho	6425	5	may	may	MD
cord-006229-7yoilsho	6425	6	develop	develop	VB
cord-006229-7yoilsho	6425	7	chlorine	chlorine	NN
cord-006229-7yoilsho	6425	8	gas	gas	NN
cord-006229-7yoilsho	6425	9	when	when	WRB
cord-006229-7yoilsho	6425	10	acidified	acidify	VBN
cord-006229-7yoilsho	6425	11	e.g.	e.g.	RB
cord-006229-7yoilsho	6425	12	by	by	IN
cord-006229-7yoilsho	6425	13	adding	add	VBG
cord-006229-7yoilsho	6425	14	an	an	DT
cord-006229-7yoilsho	6425	15	acid	acid	NN
cord-006229-7yoilsho	6425	16	sanitary	sanitary	JJ
cord-006229-7yoilsho	6425	17	cleaner	cleaner	NN
cord-006229-7yoilsho	6425	18	.	.	.
cord-006229-7yoilsho	6426	1	Usually	usually	RB
cord-006229-7yoilsho	6426	2	these	these	DT
cord-006229-7yoilsho	6426	3	cleaners	cleaner	NNS
cord-006229-7yoilsho	6426	4	contain	contain	VBP
cord-006229-7yoilsho	6426	5	sodium	sodium	NN
cord-006229-7yoilsho	6426	6	hydroxide	hydroxide	NN
cord-006229-7yoilsho	6426	7	or	or	CC
cord-006229-7yoilsho	6426	8	other	other	JJ
cord-006229-7yoilsho	6426	9	strong	strong	JJ
cord-006229-7yoilsho	6426	10	alkalines	alkaline	NNS
cord-006229-7yoilsho	6426	11	to	to	TO
cord-006229-7yoilsho	6426	12	avoid	avoid	VB
cord-006229-7yoilsho	6426	13	this	this	DT
cord-006229-7yoilsho	6426	14	reaction	reaction	NN
cord-006229-7yoilsho	6426	15	.	.	.
cord-006229-7yoilsho	6427	1	We	-PRON-	PRP
cord-006229-7yoilsho	6427	2	analysed	analyse	VBD
cord-006229-7yoilsho	6427	3	reports	report	NNS
cord-006229-7yoilsho	6427	4	to	to	IN
cord-006229-7yoilsho	6427	5	our	-PRON-	PRP$
cord-006229-7yoilsho	6427	6	poisons	poison	NNS
cord-006229-7yoilsho	6427	7	center	center	VBP
cord-006229-7yoilsho	6427	8	concerning	concern	VBG
cord-006229-7yoilsho	6427	9	inhalation	inhalation	NN
cord-006229-7yoilsho	6427	10	exposure	exposure	NN
cord-006229-7yoilsho	6427	11	to	to	IN
cord-006229-7yoilsho	6427	12	chlorine	chlorine	NN
cord-006229-7yoilsho	6427	13	developed	develop	VBN
cord-006229-7yoilsho	6427	14	from	from	IN
cord-006229-7yoilsho	6427	15	hypochlorite	hypochlorite	NN
cord-006229-7yoilsho	6427	16	-	-	HYPH
cord-006229-7yoilsho	6427	17	containing	contain	VBG
cord-006229-7yoilsho	6427	18	mixtures	mixture	NNS
cord-006229-7yoilsho	6427	19	.	.	.
cord-006229-7yoilsho	6428	1	Method	method	NN
cord-006229-7yoilsho	6428	2	:	:	:
cord-006229-7yoilsho	6428	3	Retrospective	retrospective	JJ
cord-006229-7yoilsho	6428	4	search	search	NN
cord-006229-7yoilsho	6428	5	in	in	IN
cord-006229-7yoilsho	6428	6	the	the	DT
cord-006229-7yoilsho	6428	7	case	case	NN
cord-006229-7yoilsho	6428	8	database	database	NN
cord-006229-7yoilsho	6428	9	of	of	IN
cord-006229-7yoilsho	6428	10	the	the	DT
cord-006229-7yoilsho	6428	11	poisons	poison	NNS
cord-006229-7yoilsho	6428	12	center	center	NN
cord-006229-7yoilsho	6428	13	.	.	.
cord-006229-7yoilsho	6429	1	Human	human	JJ
cord-006229-7yoilsho	6429	2	inhalative	inhalative	JJ
cord-006229-7yoilsho	6429	3	exposures	exposure	NNS
cord-006229-7yoilsho	6429	4	to	to	TO
cord-006229-7yoilsho	6429	5	chlorine	chlorine	VB
cord-006229-7yoilsho	6429	6	released	release	VBN
cord-006229-7yoilsho	6429	7	from	from	IN
cord-006229-7yoilsho	6429	8	mixing	mix	VBG
cord-006229-7yoilsho	6429	9	hypochlorite	hypochlorite	NN
cord-006229-7yoilsho	6429	10	as	as	RB
cord-006229-7yoilsho	6429	11	well	well	RB
cord-006229-7yoilsho	6429	12	as	as	IN
cord-006229-7yoilsho	6430	1	human	human	JJ
cord-006229-7yoilsho	6430	2	inhalative	inhalative	NNP
cord-006229-7yoilsho	6430	3	hypochlorite	hypochlorite	NNP
cord-006229-7yoilsho	6430	4	exposure	exposure	NN
cord-006229-7yoilsho	6430	5	alone	alone	RB
cord-006229-7yoilsho	6430	6	were	be	VBD
cord-006229-7yoilsho	6430	7	analysed	analyse	VBN
cord-006229-7yoilsho	6430	8	.	.	.
cord-006229-7yoilsho	6431	1	Frequency	frequency	NN
cord-006229-7yoilsho	6431	2	and	and	CC
cord-006229-7yoilsho	6431	3	symptoms	symptom	NNS
cord-006229-7yoilsho	6431	4	were	be	VBD
cord-006229-7yoilsho	6431	5	compared	compare	VBN
cord-006229-7yoilsho	6431	6	.	.	.
cord-006229-7yoilsho	6432	1	Results	result	NNS
cord-006229-7yoilsho	6432	2	:	:	:
cord-006229-7yoilsho	6433	1	From	from	IN
cord-006229-7yoilsho	6433	2	2010	2010	CD
cord-006229-7yoilsho	6433	3	to	to	IN
cord-006229-7yoilsho	6433	4	2015	2015	CD
cord-006229-7yoilsho	6433	5	in	in	IN
cord-006229-7yoilsho	6433	6	total	total	JJ
cord-006229-7yoilsho	6433	7	85	85	CD
cord-006229-7yoilsho	6433	8	cases	case	NNS
cord-006229-7yoilsho	6433	9	of	of	IN
cord-006229-7yoilsho	6433	10	human	human	JJ
cord-006229-7yoilsho	6433	11	exposures	exposure	NNS
cord-006229-7yoilsho	6433	12	to	to	TO
cord-006229-7yoilsho	6433	13	chlorine	chlorine	VB
cord-006229-7yoilsho	6433	14	developed	develop	VBN
cord-006229-7yoilsho	6433	15	from	from	IN
cord-006229-7yoilsho	6433	16	mixtures	mixture	NNS
cord-006229-7yoilsho	6433	17	of	of	IN
cord-006229-7yoilsho	6433	18	hypochlorite	hypochlorite	NN
cord-006229-7yoilsho	6433	19	and	and	CC
cord-006229-7yoilsho	6433	20	acids	acid	NNS
cord-006229-7yoilsho	6433	21	(	(	-LRB-
cord-006229-7yoilsho	6433	22	0.8	0.8	CD
cord-006229-7yoilsho	6433	23	of	of	IN
cord-006229-7yoilsho	6433	24	1000	1000	CD
cord-006229-7yoilsho	6433	25	cases	case	NNS
cord-006229-7yoilsho	6433	26	)	)	-RRB-
cord-006229-7yoilsho	6433	27	were	be	VBD
cord-006229-7yoilsho	6433	28	registered	register	VBN
cord-006229-7yoilsho	6433	29	.	.	.
cord-006229-7yoilsho	6434	1	In	in	IN
cord-006229-7yoilsho	6434	2	55	55	CD
cord-006229-7yoilsho	6434	3	Cases	case	NNS
cord-006229-7yoilsho	6434	4	the	the	DT
cord-006229-7yoilsho	6434	5	exposure	exposure	NN
cord-006229-7yoilsho	6434	6	was	be	VBD
cord-006229-7yoilsho	6434	7	due	due	JJ
cord-006229-7yoilsho	6434	8	to	to	IN
cord-006229-7yoilsho	6434	9	mixtures	mixture	NNS
cord-006229-7yoilsho	6434	10	of	of	IN
cord-006229-7yoilsho	6434	11	products	product	NNS
cord-006229-7yoilsho	6434	12	intended	intend	VBN
cord-006229-7yoilsho	6434	13	for	for	IN
cord-006229-7yoilsho	6434	14	domestic	domestic	JJ
cord-006229-7yoilsho	6434	15	use	use	NN
cord-006229-7yoilsho	6434	16	.	.	.
cord-006229-7yoilsho	6435	1	94	94	CD
cord-006229-7yoilsho	6435	2	%	%	NN
cord-006229-7yoilsho	6435	3	of	of	IN
cord-006229-7yoilsho	6435	4	the	the	DT
cord-006229-7yoilsho	6435	5	exposed	expose	VBN
cord-006229-7yoilsho	6435	6	patients	patient	NNS
cord-006229-7yoilsho	6435	7	reported	report	VBD
cord-006229-7yoilsho	6435	8	symptoms	symptom	NNS
cord-006229-7yoilsho	6435	9	.	.	.
cord-006229-7yoilsho	6436	1	Only	only	RB
cord-006229-7yoilsho	6436	2	in	in	IN
cord-006229-7yoilsho	6436	3	two	two	CD
cord-006229-7yoilsho	6436	4	cases	case	NNS
cord-006229-7yoilsho	6436	5	the	the	DT
cord-006229-7yoilsho	6436	6	symptoms	symptom	NNS
cord-006229-7yoilsho	6436	7	were	be	VBD
cord-006229-7yoilsho	6436	8	not	not	RB
cord-006229-7yoilsho	6436	9	considered	consider	VBN
cord-006229-7yoilsho	6436	10	to	to	TO
cord-006229-7yoilsho	6436	11	be	be	VB
cord-006229-7yoilsho	6436	12	caused	cause	VBN
cord-006229-7yoilsho	6436	13	by	by	IN
cord-006229-7yoilsho	6436	14	the	the	DT
cord-006229-7yoilsho	6436	15	inhalation	inhalation	NN
cord-006229-7yoilsho	6436	16	accident	accident	NN
cord-006229-7yoilsho	6436	17	.	.	.
cord-006229-7yoilsho	6437	1	Most	Most	JJS
cord-006229-7yoilsho	6437	2	frequent	frequent	JJ
cord-006229-7yoilsho	6437	3	symptoms	symptom	NNS
cord-006229-7yoilsho	6437	4	reported	report	VBN
cord-006229-7yoilsho	6437	5	were	be	VBD
cord-006229-7yoilsho	6437	6	(	(	-LRB-
cord-006229-7yoilsho	6437	7	percent	percent	NN
cord-006229-7yoilsho	6437	8	of	of	IN
cord-006229-7yoilsho	6437	9	symptomatic	symptomatic	JJ
cord-006229-7yoilsho	6437	10	patients	patient	NNS
cord-006229-7yoilsho	6437	11	)	)	-RRB-
cord-006229-7yoilsho	6437	12	:	:	:
cord-006229-7yoilsho	6438	1	Cough	cough	NN
cord-006229-7yoilsho	6438	2	(	(	-LRB-
cord-006229-7yoilsho	6438	3	45	45	CD
cord-006229-7yoilsho	6438	4	%	%	NN
cord-006229-7yoilsho	6438	5	)	)	-RRB-
cord-006229-7yoilsho	6438	6	,	,	,
cord-006229-7yoilsho	6438	7	dyspnea	dyspnea	NN
cord-006229-7yoilsho	6438	8	(	(	-LRB-
cord-006229-7yoilsho	6438	9	33	33	CD
cord-006229-7yoilsho	6438	10	%	%	NN
cord-006229-7yoilsho	6438	11	)	)	-RRB-
cord-006229-7yoilsho	6438	12	,	,	,
cord-006229-7yoilsho	6438	13	irritated	irritated	JJ
cord-006229-7yoilsho	6438	14	upper	upper	JJ
cord-006229-7yoilsho	6438	15	airway	airway	NN
cord-006229-7yoilsho	6438	16	(	(	-LRB-
cord-006229-7yoilsho	6438	17	26	26	CD
cord-006229-7yoilsho	6438	18	%	%	NN
cord-006229-7yoilsho	6438	19	)	)	-RRB-
cord-006229-7yoilsho	6438	20	,	,	,
cord-006229-7yoilsho	6438	21	abdominal	abdominal	JJ
cord-006229-7yoilsho	6438	22	discomfort	discomfort	NN
cord-006229-7yoilsho	6438	23	(	(	-LRB-
cord-006229-7yoilsho	6438	24	pain	pain	NN
cord-006229-7yoilsho	6438	25	,	,	,
cord-006229-7yoilsho	6438	26	nausea	nausea	NN
cord-006229-7yoilsho	6438	27	,	,	,
cord-006229-7yoilsho	6438	28	vomiting	vomit	VBG
cord-006229-7yoilsho	6438	29	)	)	-RRB-
cord-006229-7yoilsho	6438	30	(	(	-LRB-
cord-006229-7yoilsho	6438	31	21	21	CD
cord-006229-7yoilsho	6438	32	%	%	NN
cord-006229-7yoilsho	6438	33	)	)	-RRB-
cord-006229-7yoilsho	6438	34	,	,	,
cord-006229-7yoilsho	6438	35	thoracic	thoracic	JJ
cord-006229-7yoilsho	6438	36	pain	pain	NN
cord-006229-7yoilsho	6438	37	(	(	-LRB-
cord-006229-7yoilsho	6438	38	20	20	CD
cord-006229-7yoilsho	6438	39	%	%	NN
cord-006229-7yoilsho	6438	40	)	)	-RRB-
cord-006229-7yoilsho	6438	41	,	,	,
cord-006229-7yoilsho	6438	42	irritated	irritated	JJ
cord-006229-7yoilsho	6438	43	eyes	eye	NNS
cord-006229-7yoilsho	6438	44	(	(	-LRB-
cord-006229-7yoilsho	6438	45	11	11	CD
cord-006229-7yoilsho	6438	46	%	%	NN
cord-006229-7yoilsho	6438	47	)	)	-RRB-
cord-006229-7yoilsho	6438	48	,	,	,
cord-006229-7yoilsho	6438	49	dizziness	dizziness	NN
cord-006229-7yoilsho	6438	50	(	(	-LRB-
cord-006229-7yoilsho	6438	51	8	8	CD
cord-006229-7yoilsho	6438	52	%	%	NN
cord-006229-7yoilsho	6438	53	)	)	-RRB-
cord-006229-7yoilsho	6438	54	,	,	,
cord-006229-7yoilsho	6438	55	and	and	CC
cord-006229-7yoilsho	6438	56	bronchospasm	bronchospasm	JJ
cord-006229-7yoilsho	6438	57	(	(	-LRB-
cord-006229-7yoilsho	6438	58	6	6	CD
cord-006229-7yoilsho	6438	59	%	%	NN
cord-006229-7yoilsho	6438	60	)	)	-RRB-
cord-006229-7yoilsho	6438	61	.	.	.
cord-006229-7yoilsho	6439	1	Further	further	JJ
cord-006229-7yoilsho	6439	2	symptoms	symptom	NNS
cord-006229-7yoilsho	6439	3	were	be	VBD
cord-006229-7yoilsho	6439	4	malaise	malaise	NN
cord-006229-7yoilsho	6439	5	,	,	,
cord-006229-7yoilsho	6439	6	headache	headache	NN
cord-006229-7yoilsho	6439	7	,	,	,
cord-006229-7yoilsho	6439	8	irritated	irritated	JJ
cord-006229-7yoilsho	6439	9	nose	nose	NN
cord-006229-7yoilsho	6439	10	,	,	,
cord-006229-7yoilsho	6439	11	sweating	sweating	NN
cord-006229-7yoilsho	6439	12	,	,	,
cord-006229-7yoilsho	6439	13	muscle	muscle	NN
cord-006229-7yoilsho	6439	14	pain	pain	NN
cord-006229-7yoilsho	6439	15	,	,	,
cord-006229-7yoilsho	6439	16	and	and	CC
cord-006229-7yoilsho	6439	17	others	other	NNS
cord-006229-7yoilsho	6439	18	.	.	.
cord-006229-7yoilsho	6440	1	In	in	IN
cord-006229-7yoilsho	6440	2	12	12	CD
cord-006229-7yoilsho	6440	3	patients	patient	NNS
cord-006229-7yoilsho	6440	4	(	(	-LRB-
cord-006229-7yoilsho	6440	5	14	14	CD
cord-006229-7yoilsho	6440	6	%	%	NN
cord-006229-7yoilsho	6440	7	)	)	-RRB-
cord-006229-7yoilsho	6440	8	the	the	DT
cord-006229-7yoilsho	6440	9	symptoms	symptom	NNS
cord-006229-7yoilsho	6440	10	were	be	VBD
cord-006229-7yoilsho	6440	11	graded	grade	VBN
cord-006229-7yoilsho	6440	12	as	as	IN
cord-006229-7yoilsho	6440	13	moderate	moderate	JJ
cord-006229-7yoilsho	6440	14	severe	severe	NN
cord-006229-7yoilsho	6440	15	.	.	.
cord-006229-7yoilsho	6441	1	Main	main	JJ
cord-006229-7yoilsho	6441	2	symptoms	symptom	NNS
cord-006229-7yoilsho	6441	3	in	in	IN
cord-006229-7yoilsho	6441	4	this	this	DT
cord-006229-7yoilsho	6441	5	group	group	NN
cord-006229-7yoilsho	6441	6	were	be	VBD
cord-006229-7yoilsho	6441	7	dyspnoea	dyspnoea	NNS
cord-006229-7yoilsho	6441	8	(	(	-LRB-
cord-006229-7yoilsho	6441	9	83	83	CD
cord-006229-7yoilsho	6441	10	%	%	NN
cord-006229-7yoilsho	6441	11	)	)	-RRB-
cord-006229-7yoilsho	6441	12	,	,	,
cord-006229-7yoilsho	6441	13	cough	cough	NN
cord-006229-7yoilsho	6441	14	,	,	,
cord-006229-7yoilsho	6441	15	and	and	CC
cord-006229-7yoilsho	6441	16	irritated	irritated	JJ
cord-006229-7yoilsho	6441	17	airway	airway	NN
cord-006229-7yoilsho	6441	18	.	.	.
cord-006229-7yoilsho	6442	1	One	one	CD
cord-006229-7yoilsho	6442	2	third	third	NN
cord-006229-7yoilsho	6442	3	of	of	IN
cord-006229-7yoilsho	6442	4	the	the	DT
cord-006229-7yoilsho	6442	5	patients	patient	NNS
cord-006229-7yoilsho	6442	6	experienced	experience	VBD
cord-006229-7yoilsho	6442	7	bronchial	bronchial	JJ
cord-006229-7yoilsho	6442	8	obstruction	obstruction	NN
cord-006229-7yoilsho	6442	9	.	.	.
cord-006229-7yoilsho	6443	1	All	all	DT
cord-006229-7yoilsho	6443	2	symptomatic	symptomatic	JJ
cord-006229-7yoilsho	6443	3	patients	patient	NNS
cord-006229-7yoilsho	6443	4	developed	develop	VBD
cord-006229-7yoilsho	6443	5	symptoms	symptom	NNS
cord-006229-7yoilsho	6443	6	while	while	IN
cord-006229-7yoilsho	6443	7	exposed	expose	VBN
cord-006229-7yoilsho	6443	8	or	or	CC
cord-006229-7yoilsho	6443	9	shortly	shortly	RB
cord-006229-7yoilsho	6443	10	after	after	IN
cord-006229-7yoilsho	6443	11	exposure	exposure	NN
cord-006229-7yoilsho	6443	12	.	.	.
cord-006229-7yoilsho	6444	1	There	there	EX
cord-006229-7yoilsho	6444	2	were	be	VBD
cord-006229-7yoilsho	6444	3	no	no	DT
cord-006229-7yoilsho	6444	4	severe	severe	JJ
cord-006229-7yoilsho	6444	5	or	or	CC
cord-006229-7yoilsho	6444	6	fatal	fatal	JJ
cord-006229-7yoilsho	6444	7	cases	case	NNS
cord-006229-7yoilsho	6444	8	(	(	-LRB-
cord-006229-7yoilsho	6444	9	especially	especially	RB
cord-006229-7yoilsho	6444	10	no	no	DT
cord-006229-7yoilsho	6444	11	lung	lung	NN
cord-006229-7yoilsho	6444	12	edema	edema	NN
cord-006229-7yoilsho	6444	13	)	)	-RRB-
cord-006229-7yoilsho	6444	14	and	and	CC
cord-006229-7yoilsho	6444	15	all	all	DT
cord-006229-7yoilsho	6444	16	symptoms	symptom	NNS
cord-006229-7yoilsho	6444	17	were	be	VBD
cord-006229-7yoilsho	6444	18	expected	expect	VBN
cord-006229-7yoilsho	6444	19	to	to	TO
cord-006229-7yoilsho	6444	20	resolve	resolve	VB
cord-006229-7yoilsho	6444	21	completely	completely	RB
cord-006229-7yoilsho	6444	22	.	.	.
cord-006229-7yoilsho	6445	1	Because	because	IN
cord-006229-7yoilsho	6445	2	hypochlorite	hypochlorite	NN
cord-006229-7yoilsho	6445	3	containing	contain	VBG
cord-006229-7yoilsho	6445	4	procucts	procucts	NNP
cord-006229-7yoilsho	6445	5	sontanously	sontanously	NNP
cord-006229-7yoilsho	6445	6	release	release	NNP
cord-006229-7yoilsho	6445	7	"	"	``
cord-006229-7yoilsho	6445	8	chlorine	chlorine	NN
cord-006229-7yoilsho	6445	9	-	-	HYPH
cord-006229-7yoilsho	6445	10	like	like	JJ
cord-006229-7yoilsho	6445	11	"	"	``
cord-006229-7yoilsho	6445	12	smelling	smell	VBG
cord-006229-7yoilsho	6445	13	gases	gas	NNS
cord-006229-7yoilsho	6445	14	,	,	,
cord-006229-7yoilsho	6445	15	we	-PRON-	PRP
cord-006229-7yoilsho	6445	16	additionally	additionally	RB
cord-006229-7yoilsho	6445	17	analysed	analyse	VBD
cord-006229-7yoilsho	6445	18	inhalation	inhalation	NN
cord-006229-7yoilsho	6445	19	exposures	exposure	NNS
cord-006229-7yoilsho	6445	20	to	to	IN
cord-006229-7yoilsho	6445	21	hypochlorite	hypochlorite	NN
cord-006229-7yoilsho	6445	22	solutions	solution	NNS
cord-006229-7yoilsho	6445	23	alone	alone	JJ
cord-006229-7yoilsho	6445	24	in	in	IN
cord-006229-7yoilsho	6445	25	the	the	DT
cord-006229-7yoilsho	6445	26	same	same	JJ
cord-006229-7yoilsho	6445	27	period	period	NN
cord-006229-7yoilsho	6445	28	.	.	.
cord-006229-7yoilsho	6446	1	There	there	EX
cord-006229-7yoilsho	6446	2	were	be	VBD
cord-006229-7yoilsho	6446	3	42	42	CD
cord-006229-7yoilsho	6446	4	patients	patient	NNS
cord-006229-7yoilsho	6446	5	in	in	IN
cord-006229-7yoilsho	6446	6	the	the	DT
cord-006229-7yoilsho	6446	7	same	same	JJ
cord-006229-7yoilsho	6446	8	period	period	NN
cord-006229-7yoilsho	6446	9	exposed	expose	VBN
cord-006229-7yoilsho	6446	10	to	to	IN
cord-006229-7yoilsho	6446	11	hypochlorite	hypochlorite	NN
cord-006229-7yoilsho	6446	12	evaporation	evaporation	NN
cord-006229-7yoilsho	6446	13	alone	alone	RB
cord-006229-7yoilsho	6446	14	.	.	.
cord-006229-7yoilsho	6447	1	36	36	CD
cord-006229-7yoilsho	6447	2	of	of	IN
cord-006229-7yoilsho	6447	3	them	-PRON-	PRP
cord-006229-7yoilsho	6447	4	(	(	-LRB-
cord-006229-7yoilsho	6447	5	86	86	CD
cord-006229-7yoilsho	6447	6	%	%	NN
cord-006229-7yoilsho	6447	7	)	)	-RRB-
cord-006229-7yoilsho	6447	8	had	have	VBD
cord-006229-7yoilsho	6447	9	symptoms	symptom	NNS
cord-006229-7yoilsho	6447	10	of	of	IN
cord-006229-7yoilsho	6447	11	which	which	WDT
cord-006229-7yoilsho	6447	12	in	in	IN
cord-006229-7yoilsho	6447	13	30	30	CD
cord-006229-7yoilsho	6447	14	cases	case	NNS
cord-006229-7yoilsho	6447	15	these	these	DT
cord-006229-7yoilsho	6447	16	were	be	VBD
cord-006229-7yoilsho	6447	17	considered	consider	VBN
cord-006229-7yoilsho	6447	18	to	to	TO
cord-006229-7yoilsho	6447	19	be	be	VB
cord-006229-7yoilsho	6447	20	caused	cause	VBN
cord-006229-7yoilsho	6447	21	or	or	CC
cord-006229-7yoilsho	6447	22	possibly	possibly	RB
cord-006229-7yoilsho	6447	23	be	be	VB
cord-006229-7yoilsho	6447	24	caused	cause	VBN
cord-006229-7yoilsho	6447	25	by	by	IN
cord-006229-7yoilsho	6447	26	the	the	DT
cord-006229-7yoilsho	6447	27	hypochlorite	hypochlorite	NN
cord-006229-7yoilsho	6447	28	.	.	.
cord-006229-7yoilsho	6448	1	Most	Most	JJS
cord-006229-7yoilsho	6448	2	frequent	frequent	JJ
cord-006229-7yoilsho	6448	3	symptoms	symptom	NNS
cord-006229-7yoilsho	6448	4	were	be	VBD
cord-006229-7yoilsho	6448	5	irritated	irritated	JJ
cord-006229-7yoilsho	6448	6	upper	upper	JJ
cord-006229-7yoilsho	6448	7	airway	airway	NN
cord-006229-7yoilsho	6448	8	(	(	-LRB-
cord-006229-7yoilsho	6448	9	33	33	CD
cord-006229-7yoilsho	6448	10	%	%	NN
cord-006229-7yoilsho	6448	11	)	)	-RRB-
cord-006229-7yoilsho	6448	12	,	,	,
cord-006229-7yoilsho	6448	13	nausea	nausea	NN
cord-006229-7yoilsho	6448	14	or	or	CC
cord-006229-7yoilsho	6448	15	vomiting	vomiting	NN
cord-006229-7yoilsho	6448	16	(	(	-LRB-
cord-006229-7yoilsho	6448	17	30	30	CD
cord-006229-7yoilsho	6448	18	%	%	NN
cord-006229-7yoilsho	6448	19	)	)	-RRB-
cord-006229-7yoilsho	6448	20	,	,	,
cord-006229-7yoilsho	6448	21	cough	cough	NN
cord-006229-7yoilsho	6448	22	(	(	-LRB-
cord-006229-7yoilsho	6448	23	23	23	CD
cord-006229-7yoilsho	6448	24	%	%	NN
cord-006229-7yoilsho	6448	25	)	)	-RRB-
cord-006229-7yoilsho	6448	26	,	,	,
cord-006229-7yoilsho	6448	27	irritated	irritated	JJ
cord-006229-7yoilsho	6448	28	eyes	eye	NNS
cord-006229-7yoilsho	6448	29	(	(	-LRB-
cord-006229-7yoilsho	6448	30	20	20	CD
cord-006229-7yoilsho	6448	31	%	%	NN
cord-006229-7yoilsho	6448	32	)	)	-RRB-
cord-006229-7yoilsho	6448	33	.	.	.
cord-006229-7yoilsho	6449	1	Dyspneoa	Dyspneoa	NNP
cord-006229-7yoilsho	6449	2	was	be	VBD
cord-006229-7yoilsho	6449	3	less	less	RBR
cord-006229-7yoilsho	6449	4	fequent	fequent	JJ
cord-006229-7yoilsho	6449	5	than	than	IN
cord-006229-7yoilsho	6449	6	in	in	IN
cord-006229-7yoilsho	6449	7	the	the	DT
cord-006229-7yoilsho	6449	8	mixture	mixture	NN
cord-006229-7yoilsho	6449	9	group	group	NN
cord-006229-7yoilsho	6449	10	(	(	-LRB-
cord-006229-7yoilsho	6449	11	10	10	CD
cord-006229-7yoilsho	6449	12	%	%	NN
cord-006229-7yoilsho	6449	13	)	)	-RRB-
cord-006229-7yoilsho	6449	14	.	.	.
cord-006229-7yoilsho	6450	1	All	all	DT
cord-006229-7yoilsho	6450	2	symptoms	symptom	NNS
cord-006229-7yoilsho	6450	3	were	be	VBD
cord-006229-7yoilsho	6450	4	considered	consider	VBN
cord-006229-7yoilsho	6450	5	mild	mild	JJ
cord-006229-7yoilsho	6450	6	.	.	.
cord-006229-7yoilsho	6451	1	There	there	EX
cord-006229-7yoilsho	6451	2	was	be	VBD
cord-006229-7yoilsho	6451	3	no	no	DT
cord-006229-7yoilsho	6451	4	bronchospasm	bronchospasm	JJ
cord-006229-7yoilsho	6451	5	or	or	CC
cord-006229-7yoilsho	6451	6	thoracic	thoracic	JJ
cord-006229-7yoilsho	6451	7	discomfort	discomfort	NN
cord-006229-7yoilsho	6451	8	.	.	.
cord-006229-7yoilsho	6452	1	Conclusion	conclusion	NN
cord-006229-7yoilsho	6452	2	:	:	:
cord-006229-7yoilsho	6452	3	Respiratory	respiratory	JJ
cord-006229-7yoilsho	6452	4	injuries	injury	NNS
cord-006229-7yoilsho	6452	5	by	by	IN
cord-006229-7yoilsho	6452	6	chlorine	chlorine	NN
cord-006229-7yoilsho	6452	7	from	from	IN
cord-006229-7yoilsho	6452	8	hypochlorite	hypochlorite	NN
cord-006229-7yoilsho	6452	9	-	-	HYPH
cord-006229-7yoilsho	6452	10	containing	contain	VBG
cord-006229-7yoilsho	6452	11	solutions	solution	NNS
cord-006229-7yoilsho	6452	12	still	still	RB
cord-006229-7yoilsho	6452	13	occur	occur	VBP
cord-006229-7yoilsho	6452	14	despite	despite	IN
cord-006229-7yoilsho	6452	15	clear	clear	JJ
cord-006229-7yoilsho	6452	16	warning	warning	NN
cord-006229-7yoilsho	6452	17	on	on	IN
cord-006229-7yoilsho	6452	18	the	the	DT
cord-006229-7yoilsho	6452	19	label	label	NN
cord-006229-7yoilsho	6452	20	.	.	.
cord-006229-7yoilsho	6453	1	The	the	DT
cord-006229-7yoilsho	6453	2	majority	majority	NN
cord-006229-7yoilsho	6453	3	of	of	IN
cord-006229-7yoilsho	6453	4	cases	case	NNS
cord-006229-7yoilsho	6453	5	was	be	VBD
cord-006229-7yoilsho	6453	6	due	due	JJ
cord-006229-7yoilsho	6453	7	to	to	IN
cord-006229-7yoilsho	6453	8	products	product	NNS
cord-006229-7yoilsho	6453	9	for	for	IN
cord-006229-7yoilsho	6453	10	domestic	domestic	JJ
cord-006229-7yoilsho	6453	11	use	use	NN
cord-006229-7yoilsho	6453	12	.	.	.
cord-006229-7yoilsho	6454	1	Symptoms	symptom	NNS
cord-006229-7yoilsho	6454	2	develop	develop	VBP
cord-006229-7yoilsho	6454	3	shortly	shortly	RB
cord-006229-7yoilsho	6454	4	after	after	IN
cord-006229-7yoilsho	6454	5	exposure	exposure	NN
cord-006229-7yoilsho	6454	6	.	.	.
cord-006229-7yoilsho	6455	1	The	the	DT
cord-006229-7yoilsho	6455	2	γH2AX	γH2AX	NNP
cord-006229-7yoilsho	6455	3	Assay	Assay	NNP
cord-006229-7yoilsho	6455	4	for	for	IN
cord-006229-7yoilsho	6455	5	Genotoxic	Genotoxic	NNP
cord-006229-7yoilsho	6455	6	and	and	CC
cord-006229-7yoilsho	6455	7	Nongenotoxic	Nongenotoxic	NNP
cord-006229-7yoilsho	6455	8	Agents	agent	NNS
cord-006229-7yoilsho	6455	9	:	:	:
cord-006229-7yoilsho	6455	10	Comparison	comparison	NN
cord-006229-7yoilsho	6455	11	of	of	IN
cord-006229-7yoilsho	6455	12	H2AX	H2AX	NNP
cord-006229-7yoilsho	6455	13	Phosphorylation	Phosphorylation	NNP
cord-006229-7yoilsho	6455	14	with	with	IN
cord-006229-7yoilsho	6455	15	Cell	Cell	NNP
cord-006229-7yoilsho	6455	16	Death	Death	NNP
cord-006229-7yoilsho	6455	17	Response	Response	NNP
cord-006229-7yoilsho	6455	18	Perturbation	perturbation	NN
cord-006229-7yoilsho	6455	19	of	of	IN
cord-006229-7yoilsho	6455	20	mitosis	mitosis	NN
cord-006229-7yoilsho	6455	21	through	through	IN
cord-006229-7yoilsho	6455	22	inhibition	inhibition	NN
cord-006229-7yoilsho	6455	23	of	of	IN
cord-006229-7yoilsho	6455	24	histone	histone	NN
cord-006229-7yoilsho	6455	25	acetyltransferases	acetyltransferase	NNS
cord-006229-7yoilsho	6455	26	:	:	:
cord-006229-7yoilsho	6455	27	the	the	DT
cord-006229-7yoilsho	6455	28	key	key	NN
cord-006229-7yoilsho	6455	29	to	to	TO
cord-006229-7yoilsho	6455	30	ochratoxin	ochratoxin	VB
cord-006229-7yoilsho	6455	31	a	a	DT
cord-006229-7yoilsho	6455	32	toxicity	toxicity	NN
cord-006229-7yoilsho	6455	33	and	and	CC
cord-006229-7yoilsho	6455	34	carcinogenicity	carcinogenicity	NN
cord-006229-7yoilsho	6455	35	?	?	.
cord-006229-7yoilsho	6456	1	Regulation	regulation	NN
cord-006229-7yoilsho	6456	2	of	of	IN
cord-006229-7yoilsho	6456	3	chromatin	chromatin	NN
cord-006229-7yoilsho	6456	4	by	by	IN
cord-006229-7yoilsho	6456	5	histone	histone	NN
cord-006229-7yoilsho	6456	6	modifications	modification	NNS
cord-006229-7yoilsho	6457	1	Transcriptomic	Transcriptomic	NNP
cord-006229-7yoilsho	6457	2	alterations	alteration	NNS
cord-006229-7yoilsho	6457	3	induced	induce	VBN
cord-006229-7yoilsho	6457	4	by	by	IN
cord-006229-7yoilsho	6457	5	Ochratoxin	Ochratoxin	NNP
cord-006229-7yoilsho	6457	6	A	A	NNP
cord-006229-7yoilsho	6457	7	in	in	IN
cord-006229-7yoilsho	6457	8	rat	rat	NN
cord-006229-7yoilsho	6457	9	and	and	CC
cord-006229-7yoilsho	6457	10	human	human	JJ
cord-006229-7yoilsho	6457	11	renal	renal	NN
cord-006229-7yoilsho	6457	12	proximal	proximal	JJ
cord-006229-7yoilsho	6457	13	tubular	tubular	RB
cord-006229-7yoilsho	6457	14	in	in	IN
cord-006229-7yoilsho	6457	15	vitro	vitro	FW
cord-006229-7yoilsho	6457	16	models	model	NNS
cord-006229-7yoilsho	6457	17	and	and	CC
cord-006229-7yoilsho	6457	18	comparison	comparison	NN
cord-006229-7yoilsho	6457	19	to	to	IN
cord-006229-7yoilsho	6457	20	a	a	DT
cord-006229-7yoilsho	6457	21	rat	rat	NN
cord-006229-7yoilsho	6457	22	in	in	IN
cord-006229-7yoilsho	6457	23	vivo	vivo	NN
cord-006229-7yoilsho	6457	24	model	model	NN
cord-006229-7yoilsho	6458	1	In	in	IN
cord-006229-7yoilsho	6458	2	vitro	vitro	FW
cord-006229-7yoilsho	6458	3	gene	gene	NN
cord-006229-7yoilsho	6458	4	expression	expression	NN
cord-006229-7yoilsho	6458	5	data	datum	NNS
cord-006229-7yoilsho	6458	6	supporting	support	VBG
cord-006229-7yoilsho	6458	7	a	a	DT
cord-006229-7yoilsho	6458	8	DNA	dna	NN
cord-006229-7yoilsho	6458	9	non	non	JJ
cord-006229-7yoilsho	6458	10	-	-	JJ
cord-006229-7yoilsho	6458	11	reactive	reactive	JJ
cord-006229-7yoilsho	6458	12	genotoxic	genotoxic	JJ
cord-006229-7yoilsho	6458	13	mechanism	mechanism	NN
cord-006229-7yoilsho	6458	14	for	for	IN
cord-006229-7yoilsho	6458	15	ochratoxin	ochratoxin	NN
cord-006229-7yoilsho	6459	1	A	a	DT
cord-006229-7yoilsho	6459	2	Fragment	fragment	NN
cord-006229-7yoilsho	6459	3	Ion	ion	NN
cord-006229-7yoilsho	6459	4	Patchwork	Patchwork	NNP
cord-006229-7yoilsho	6459	5	Quantification	quantification	NN
cord-006229-7yoilsho	6459	6	for	for	IN
cord-006229-7yoilsho	6459	7	Measuring	measure	VBG
cord-006229-7yoilsho	6459	8	Site	site	NN
cord-006229-7yoilsho	6459	9	-	-	HYPH
cord-006229-7yoilsho	6459	10	Specific	specific	JJ
cord-006229-7yoilsho	6459	11	Acetylation	Acetylation	NNP
cord-006229-7yoilsho	6459	12	Degrees	Degrees	NNPS
cord-006229-7yoilsho	6459	13	Combinatorial	combinatorial	JJ
cord-006229-7yoilsho	6459	14	patterns	pattern	NNS
cord-006229-7yoilsho	6459	15	of	of	IN
cord-006229-7yoilsho	6459	16	histone	histone	NN
cord-006229-7yoilsho	6459	17	acetylations	acetylation	NNS
cord-006229-7yoilsho	6459	18	and	and	CC
cord-006229-7yoilsho	6459	19	methylations	methylation	NNS
cord-006229-7yoilsho	6459	20	in	in	IN
cord-006229-7yoilsho	6459	21	the	the	DT
cord-006229-7yoilsho	6459	22	human	human	JJ
cord-006229-7yoilsho	6459	23	genome	genome	NN
cord-006229-7yoilsho	6459	24	Inroads	inroad	NNS
cord-006229-7yoilsho	6460	1	to	to	TO
cord-006229-7yoilsho	6460	2	Predict	predict	VB
cord-006229-7yoilsho	6460	3	in	in	IN
cord-006229-7yoilsho	6460	4	Vivo	Vivo	NNP
cord-006229-7yoilsho	6460	5	Toxicology	Toxicology	NNP
cord-006229-7yoilsho	6461	1	-An	-An	NNP
cord-006229-7yoilsho	6462	1	Introduction	introduction	NN
cord-006229-7yoilsho	6462	2	to	to	IN
cord-006229-7yoilsho	6462	3	the	the	DT
cord-006229-7yoilsho	6462	4	eTOX	etox	CD
cord-006229-7yoilsho	6462	5	Project	Project	NNP
cord-006229-7yoilsho	6462	6	Value	Value	NNP
cord-006229-7yoilsho	6462	7	of	of	IN
cord-006229-7yoilsho	6462	8	shared	share	VBN
cord-006229-7yoilsho	6462	9	preclinical	preclinical	JJ
cord-006229-7yoilsho	6462	10	safety	safety	NN
cord-006229-7yoilsho	6462	11	studies	study	NNS
cord-006229-7yoilsho	6463	1	-The	-The	:
cord-006229-7yoilsho	6463	2	eTOX	etox	CD
cord-006229-7yoilsho	6463	3	database	database	NN
cord-006229-7yoilsho	6463	4	Acknowledgements	acknowledgement	NNS
cord-006229-7yoilsho	6463	5	:	:	:
cord-006229-7yoilsho	6464	1	Support	support	NN
cord-006229-7yoilsho	6464	2	of	of	IN
cord-006229-7yoilsho	6464	3	the	the	DT
cord-006229-7yoilsho	6464	4	BfR	bfr	NN
cord-006229-7yoilsho	6464	5	through	through	IN
cord-006229-7yoilsho	6464	6	grant	grant	NN
cord-006229-7yoilsho	6464	7	1322	1322	CD
cord-006229-7yoilsho	6464	8	-	-	SYM
cord-006229-7yoilsho	6464	9	530	530	CD
cord-006229-7yoilsho	6464	10	is	be	VBZ
cord-006229-7yoilsho	6464	11	gratefully	gratefully	RB
cord-006229-7yoilsho	6464	12	acknowledged	acknowledge	VBN
cord-006229-7yoilsho	6464	13	.	.	.
cord-006229-7yoilsho	6465	1	Acknowledgement	acknowledgement	NN
cord-006229-7yoilsho	6465	2	:	:	:
cord-006229-7yoilsho	6465	3	Supported	support	VBN
cord-006229-7yoilsho	6465	4	by	by	IN
cord-006229-7yoilsho	6465	5	the	the	DT
cord-006229-7yoilsho	6465	6	Robert	Robert	NNP
cord-006229-7yoilsho	6465	7	Bosch	Bosch	NNP
cord-006229-7yoilsho	6465	8	Foundation	Foundation	NNP
cord-006229-7yoilsho	6465	9	,	,	,
cord-006229-7yoilsho	6465	10	Stuttgart	Stuttgart	NNP
cord-006229-7yoilsho	6465	11	,	,	,
cord-006229-7yoilsho	6465	12	Germany	Germany	NNP
cord-006229-7yoilsho	6465	13	.	.	.
cord-006229-7yoilsho	6466	1	[	[	-LRB-
cord-006229-7yoilsho	6466	2	1	1	CD
cord-006229-7yoilsho	6466	3	]	]	-RRB-
cord-006229-7yoilsho	6466	4	Mürdter	Mürdter	NNP
cord-006229-7yoilsho	6466	5	T	T	NNP
cord-006229-7yoilsho	6466	6	,	,	,
cord-006229-7yoilsho	6466	7	et	et	NNP
cord-006229-7yoilsho	6466	8	al	al	NNP
cord-006229-7yoilsho	6466	9	.	.	.
cord-006229-7yoilsho	6467	1	Hum	Hum	NNP
cord-006229-7yoilsho	6467	2	Mol	Mol	NNP
cord-006229-7yoilsho	6467	3	Genet	Genet	NNP
cord-006229-7yoilsho	6467	4	,	,	,
cord-006229-7yoilsho	6467	5	2011	2011	CD
cord-006229-7yoilsho	6467	6	,	,	,
cord-006229-7yoilsho	6467	7	21:1145	21:1145	CD
cord-006229-7yoilsho	6467	8	-	-	SYM
cord-006229-7yoilsho	6467	9	54	54	CD
cord-006229-7yoilsho	6468	1	[	[	-LRB-
cord-006229-7yoilsho	6468	2	2	2	CD
cord-006229-7yoilsho	6468	3	]	]	-RRB-
cord-006229-7yoilsho	6469	1	Nishiyama	Nishiyama	NNP
cord-006229-7yoilsho	6469	2	T.	T.	NNP
cord-006229-7yoilsho	6469	3	et	et	FW
cord-006229-7yoilsho	6469	4	al	al	NNP
cord-006229-7yoilsho	6469	5	.	.	.
cord-006229-7yoilsho	6470	1	,	,	,
cord-006229-7yoilsho	6470	2	Biochemical	Biochemical	NNP
cord-006229-7yoilsho	6470	3	Pharmacology	Pharmacology	NNP
cord-006229-7yoilsho	6470	4	,	,	,
cord-006229-7yoilsho	6470	5	2002	2002	CD
cord-006229-7yoilsho	6470	6	,	,	,
cord-006229-7yoilsho	6470	7	63:1817	63:1817	CD
cord-006229-7yoilsho	6470	8	-1830	-1830	.
cord-006229-7yoilsho	6471	1	[	[	-LRB-
cord-006229-7yoilsho	6471	2	3	3	CD
cord-006229-7yoilsho	6471	3	]	]	-RRB-
cord-006229-7yoilsho	6472	1	Sun	Sun	NNP
cord-006229-7yoilsho	6472	2	D.	D.	NNP
cord-006229-7yoilsho	6472	3	et	et	NNP
cord-006229-7yoilsho	6472	4	al	al	NNP
cord-006229-7yoilsho	6472	5	.	.	NNP
cord-006229-7yoilsho	6472	6	,	,	,
cord-006229-7yoilsho	6472	7	Drug	Drug	NNP
cord-006229-7yoilsho	6472	8	Metabolism	Metabolism	NNP
cord-006229-7yoilsho	6472	9	and	and	CC
cord-006229-7yoilsho	6472	10	Disposition	Disposition	NNP
cord-006229-7yoilsho	6472	11	,	,	,
cord-006229-7yoilsho	6472	12	2007	2007	CD
cord-006229-7yoilsho	6472	13	,	,	,
cord-006229-7yoilsho	6473	1	35:2006	35:2006	CD
cord-006229-7yoilsho	6473	2	 	 	_SP
cord-006229-7yoilsho	6473	3	Background	Background	NNP
cord-006229-7yoilsho	6473	4	:	:	:
cord-006229-7yoilsho	6473	5	Infections	infection	NNS
cord-006229-7yoilsho	6473	6	are	be	VBP
cord-006229-7yoilsho	6473	7	a	a	DT
cord-006229-7yoilsho	6473	8	major	major	JJ
cord-006229-7yoilsho	6473	9	problem	problem	NN
cord-006229-7yoilsho	6473	10	in	in	IN
cord-006229-7yoilsho	6473	11	patients	patient	NNS
cord-006229-7yoilsho	6473	12	with	with	IN
cord-006229-7yoilsho	6473	13	burn	burn	NN
cord-006229-7yoilsho	6473	14	diseases	disease	NNS
cord-006229-7yoilsho	6473	15	(	(	-LRB-
cord-006229-7yoilsho	6473	16	BD	BD	NNP
cord-006229-7yoilsho	6473	17	)	)	-RRB-
cord-006229-7yoilsho	6473	18	.	.	.
cord-006229-7yoilsho	6474	1	Due	due	IN
cord-006229-7yoilsho	6474	2	to	to	IN
cord-006229-7yoilsho	6474	3	severe	severe	JJ
cord-006229-7yoilsho	6474	4	injuries	injury	NNS
cord-006229-7yoilsho	6474	5	of	of	IN
cord-006229-7yoilsho	6474	6	their	-PRON-	PRP$
cord-006229-7yoilsho	6474	7	total	total	JJ
cord-006229-7yoilsho	6474	8	body	body	NN
cord-006229-7yoilsho	6474	9	surface	surface	NN
cord-006229-7yoilsho	6474	10	area	area	NN
cord-006229-7yoilsho	6474	11	(	(	-LRB-
cord-006229-7yoilsho	6474	12	TBSA	TBSA	NNP
cord-006229-7yoilsho	6474	13	)	)	-RRB-
cord-006229-7yoilsho	6474	14	,	,	,
cord-006229-7yoilsho	6474	15	burn	burn	VBP
cord-006229-7yoilsho	6474	16	patients	patient	NNS
cord-006229-7yoilsho	6474	17	have	have	VBP
cord-006229-7yoilsho	6474	18	altered	alter	VBN
cord-006229-7yoilsho	6474	19	pharmacokinetic	pharmacokinetic	JJ
cord-006229-7yoilsho	6474	20	characteristics	characteristic	NNS
cord-006229-7yoilsho	6474	21	.	.	.
cord-006229-7yoilsho	6475	1	Therefore	therefore	RB
cord-006229-7yoilsho	6475	2	,	,	,
cord-006229-7yoilsho	6475	3	insufficient	insufficient	JJ
cord-006229-7yoilsho	6475	4	plasma	plasma	NN
cord-006229-7yoilsho	6475	5	concentrations	concentration	NNS
cord-006229-7yoilsho	6475	6	may	may	MD
cord-006229-7yoilsho	6475	7	be	be	VB
cord-006229-7yoilsho	6475	8	achieved	achieve	VBN
cord-006229-7yoilsho	6475	9	,	,	,
cord-006229-7yoilsho	6475	10	when	when	WRB
cord-006229-7yoilsho	6475	11	standard	standard	JJ
cord-006229-7yoilsho	6475	12	dosing	dosing	NN
cord-006229-7yoilsho	6475	13	schedules	schedule	NNS
cord-006229-7yoilsho	6475	14	are	be	VBP
cord-006229-7yoilsho	6475	15	applied	apply	VBN
cord-006229-7yoilsho	6475	16	for	for	IN
cord-006229-7yoilsho	6475	17	antibiotics	antibiotic	NNS
cord-006229-7yoilsho	6475	18	such	such	JJ
cord-006229-7yoilsho	6475	19	as	as	IN
cord-006229-7yoilsho	6475	20	piperacillin	piperacillin	NNP
cord-006229-7yoilsho	6475	21	.	.	.
cord-006229-7yoilsho	6476	1	For	for	IN
cord-006229-7yoilsho	6476	2	time	time	NN
cord-006229-7yoilsho	6476	3	-	-	HYPH
cord-006229-7yoilsho	6476	4	dependent	dependent	JJ
cord-006229-7yoilsho	6476	5	antibiotics	antibiotic	NNS
cord-006229-7yoilsho	6476	6	,	,	,
cord-006229-7yoilsho	6476	7	the	the	DT
cord-006229-7yoilsho	6476	8	duration	duration	NN
cord-006229-7yoilsho	6476	9	how	how	WRB
cord-006229-7yoilsho	6476	10	long	long	JJ
cord-006229-7yoilsho	6476	11	drug	drug	NN
cord-006229-7yoilsho	6476	12	concentration	concentration	NN
cord-006229-7yoilsho	6476	13	exceeds	exceed	VBZ
cord-006229-7yoilsho	6476	14	the	the	DT
cord-006229-7yoilsho	6476	15	minimal	minimal	JJ
cord-006229-7yoilsho	6476	16	inhibition	inhibition	NN
cord-006229-7yoilsho	6476	17	concentration	concentration	NN
cord-006229-7yoilsho	6476	18	(	(	-LRB-
cord-006229-7yoilsho	6476	19	MIC	MIC	NNP
cord-006229-7yoilsho	6476	20	)	)	-RRB-
cord-006229-7yoilsho	6476	21	is	be	VBZ
cord-006229-7yoilsho	6476	22	crucial	crucial	JJ
cord-006229-7yoilsho	6476	23	for	for	IN
cord-006229-7yoilsho	6476	24	their	-PRON-	PRP$
cord-006229-7yoilsho	6476	25	antibacterial	antibacterial	JJ
cord-006229-7yoilsho	6476	26	effects	effect	NNS
cord-006229-7yoilsho	6476	27	.	.	.
cord-006229-7yoilsho	6477	1	Since	since	IN
cord-006229-7yoilsho	6477	2	Pseudomonas	Pseudomonas	NNP
cord-006229-7yoilsho	6477	3	spp	spp	NNS
cord-006229-7yoilsho	6477	4	.	.	.
cord-006229-7yoilsho	6478	1	is	be	VBZ
cord-006229-7yoilsho	6478	2	the	the	DT
cord-006229-7yoilsho	6478	3	main	main	JJ
cord-006229-7yoilsho	6478	4	problematic	problematic	JJ
cord-006229-7yoilsho	6478	5	pathophysiological	pathophysiological	JJ
cord-006229-7yoilsho	6478	6	bacterium	bacterium	NN
cord-006229-7yoilsho	6478	7	for	for	IN
cord-006229-7yoilsho	6478	8	BD	BD	NNP
cord-006229-7yoilsho	6478	9	patients	patient	NNS
cord-006229-7yoilsho	6478	10	.	.	.
cord-006229-7yoilsho	6479	1	The	the	DT
cord-006229-7yoilsho	6479	2	aim	aim	NN
cord-006229-7yoilsho	6479	3	of	of	IN
cord-006229-7yoilsho	6479	4	the	the	DT
cord-006229-7yoilsho	6479	5	present	present	JJ
cord-006229-7yoilsho	6479	6	study	study	NN
cord-006229-7yoilsho	6479	7	was	be	VBD
cord-006229-7yoilsho	6479	8	to	to	TO
cord-006229-7yoilsho	6479	9	monitor	monitor	VB
cord-006229-7yoilsho	6479	10	the	the	DT
cord-006229-7yoilsho	6479	11	plasma	plasma	NN
cord-006229-7yoilsho	6479	12	concentrations	concentration	NNS
cord-006229-7yoilsho	6479	13	of	of	IN
cord-006229-7yoilsho	6479	14	piperacillin	piperacillin	NN
cord-006229-7yoilsho	6479	15	during	during	IN
cord-006229-7yoilsho	6479	16	piperacillin	piperacillin	NNP
cord-006229-7yoilsho	6479	17	/	/	SYM
cord-006229-7yoilsho	6479	18	tazobactam	tazobactam	NNS
cord-006229-7yoilsho	6479	19	treatment	treatment	NN
cord-006229-7yoilsho	6479	20	in	in	IN
cord-006229-7yoilsho	6479	21	BD	BD	NNP
cord-006229-7yoilsho	6479	22	patients	patient	NNS
cord-006229-7yoilsho	6479	23	.	.	.
cord-006229-7yoilsho	6480	1	Patients	patient	NNS
cord-006229-7yoilsho	6480	2	from	from	IN
cord-006229-7yoilsho	6480	3	Intensive	Intensive	NNP
cord-006229-7yoilsho	6480	4	Care	Care	NNP
cord-006229-7yoilsho	6480	5	Units	Units	NNPS
cord-006229-7yoilsho	6480	6	(	(	-LRB-
cord-006229-7yoilsho	6480	7	ICU	ICU	NNP
cord-006229-7yoilsho	6480	8	)	)	-RRB-
cord-006229-7yoilsho	6480	9	served	serve	VBD
cord-006229-7yoilsho	6480	10	as	as	IN
cord-006229-7yoilsho	6480	11	controls	control	NNS
cord-006229-7yoilsho	6480	12	.	.	.
cord-006229-7yoilsho	6481	1	Methods	method	NNS
cord-006229-7yoilsho	6481	2	:	:	:
cord-006229-7yoilsho	6481	3	10	10	CD
cord-006229-7yoilsho	6481	4	BD	BD	NNP
cord-006229-7yoilsho	6481	5	patients	patient	NNS
cord-006229-7yoilsho	6481	6	(	(	-LRB-
cord-006229-7yoilsho	6481	7	5/5	5/5	CD
cord-006229-7yoilsho	6481	8	m	m	NNP
cord-006229-7yoilsho	6481	9	/	/	SYM
cord-006229-7yoilsho	6481	10	f	f	NNP
cord-006229-7yoilsho	6481	11	,	,	,
cord-006229-7yoilsho	6481	12	43.4±5.3y	43.4±5.3y	CD
cord-006229-7yoilsho	6481	13	,	,	,
cord-006229-7yoilsho	6481	14	TBSA	TBSA	NNP
cord-006229-7yoilsho	6481	15	40	40	CD
cord-006229-7yoilsho	6481	16	.9±5.9	.9±5.9	CD
cord-006229-7yoilsho	6481	17	%	%	NN
cord-006229-7yoilsho	6481	18	)	)	-RRB-
cord-006229-7yoilsho	6481	19	and	and	CC
cord-006229-7yoilsho	6481	20	5	5	CD
cord-006229-7yoilsho	6481	21	patients	patient	NNS
cord-006229-7yoilsho	6481	22	(	(	-LRB-
cord-006229-7yoilsho	6481	23	74.4±3.9y	74.4±3.9y	CD
cord-006229-7yoilsho	6481	24	)	)	-RRB-
cord-006229-7yoilsho	6481	25	from	from	IN
cord-006229-7yoilsho	6481	26	the	the	DT
cord-006229-7yoilsho	6481	27	ICU	ICU	NNP
cord-006229-7yoilsho	6481	28	were	be	VBD
cord-006229-7yoilsho	6481	29	included	include	VBN
cord-006229-7yoilsho	6481	30	in	in	IN
cord-006229-7yoilsho	6481	31	this	this	DT
cord-006229-7yoilsho	6481	32	observational	observational	JJ
cord-006229-7yoilsho	6481	33	study	study	NN
cord-006229-7yoilsho	6481	34	.	.	.
cord-006229-7yoilsho	6482	1	Blood	blood	NN
cord-006229-7yoilsho	6482	2	samples	sample	NNS
cord-006229-7yoilsho	6482	3	were	be	VBD
cord-006229-7yoilsho	6482	4	taken	take	VBN
cord-006229-7yoilsho	6482	5	within	within	IN
cord-006229-7yoilsho	6482	6	the	the	DT
cord-006229-7yoilsho	6482	7	3	3	CD
cord-006229-7yoilsho	6482	8	rd	rd	NN
cord-006229-7yoilsho	6482	9	interval	interval	NN
cord-006229-7yoilsho	6482	10	of	of	IN
cord-006229-7yoilsho	6482	11	the	the	DT
cord-006229-7yoilsho	6482	12	8h	8h	CD
cord-006229-7yoilsho	6482	13	-	-	HYPH
cord-006229-7yoilsho	6482	14	lasting	last	VBG
cord-006229-7yoilsho	6482	15	dosing	dosing	NN
cord-006229-7yoilsho	6482	16	period	period	NN
cord-006229-7yoilsho	6482	17	of	of	IN
cord-006229-7yoilsho	6482	18	piperacillin	piperacillin	NNP
cord-006229-7yoilsho	6482	19	/	/	SYM
cord-006229-7yoilsho	6482	20	tazobactam	tazobactam	NNP
cord-006229-7yoilsho	6482	21	(	(	-LRB-
cord-006229-7yoilsho	6482	22	4/0.5	4/0.5	CD
cord-006229-7yoilsho	6482	23	g	g	NN
cord-006229-7yoilsho	6482	24	within	within	IN
cord-006229-7yoilsho	6482	25	0.5h	0.5h	CD
cord-006229-7yoilsho	6482	26	)	)	-RRB-
cord-006229-7yoilsho	6482	27	at	at	IN
cord-006229-7yoilsho	6482	28	1	1	CD
cord-006229-7yoilsho	6482	29	,	,	,
cord-006229-7yoilsho	6482	30	4	4	CD
cord-006229-7yoilsho	6482	31	and	and	CC
cord-006229-7yoilsho	6482	32	7.5h	7.5h	NN
cord-006229-7yoilsho	6482	33	after	after	IN
cord-006229-7yoilsho	6482	34	the	the	DT
cord-006229-7yoilsho	6482	35	end	end	NN
cord-006229-7yoilsho	6482	36	of	of	IN
cord-006229-7yoilsho	6482	37	infusion	infusion	NN
cord-006229-7yoilsho	6482	38	.	.	.
cord-006229-7yoilsho	6483	1	Total	total	JJ
cord-006229-7yoilsho	6483	2	and	and	CC
cord-006229-7yoilsho	6483	3	free	free	JJ
cord-006229-7yoilsho	6483	4	piperacillin	piperacillin	NN
cord-006229-7yoilsho	6483	5	concentrations	concentration	NNS
cord-006229-7yoilsho	6483	6	were	be	VBD
cord-006229-7yoilsho	6483	7	determined	determine	VBN
cord-006229-7yoilsho	6483	8	in	in	IN
cord-006229-7yoilsho	6483	9	plasma	plasma	NN
cord-006229-7yoilsho	6483	10	using	use	VBG
cord-006229-7yoilsho	6483	11	HPLC	HPLC	NNP
cord-006229-7yoilsho	6483	12	-	-	HYPH
cord-006229-7yoilsho	6483	13	UV	UV	NNP
cord-006229-7yoilsho	6483	14	after	after	IN
cord-006229-7yoilsho	6483	15	deproteinisation	deproteinisation	NN
cord-006229-7yoilsho	6483	16	with	with	IN
cord-006229-7yoilsho	6483	17	acetonitrile	acetonitrile	NN
cord-006229-7yoilsho	6483	18	and	and	CC
cord-006229-7yoilsho	6483	19	by	by	IN
cord-006229-7yoilsho	6483	20	ultrafiltration	ultrafiltration	NN
cord-006229-7yoilsho	6483	21	,	,	,
cord-006229-7yoilsho	6483	22	respectively	respectively	RB
cord-006229-7yoilsho	6483	23	.	.	.
cord-006229-7yoilsho	6484	1	Pharmacokinetic	pharmacokinetic	JJ
cord-006229-7yoilsho	6484	2	parameters	parameter	NNS
cord-006229-7yoilsho	6484	3	and	and	CC
cord-006229-7yoilsho	6484	4	dosing	dosing	NN
cord-006229-7yoilsho	6484	5	simulations	simulation	NNS
cord-006229-7yoilsho	6484	6	were	be	VBD
cord-006229-7yoilsho	6484	7	calculated	calculate	VBN
cord-006229-7yoilsho	6484	8	by	by	IN
cord-006229-7yoilsho	6484	9	TDMx	TDMx	NNS
cord-006229-7yoilsho	6484	10	(	(	-LRB-
cord-006229-7yoilsho	6484	11	www.tdmx.eu	www.tdmx.eu	NNP
cord-006229-7yoilsho	6484	12	)	)	-RRB-
cord-006229-7yoilsho	6484	13	.	.	.
cord-006229-7yoilsho	6485	1	Free	free	JJ
cord-006229-7yoilsho	6485	2	plasma	plasma	NN
cord-006229-7yoilsho	6485	3	concentrations	concentration	NNS
cord-006229-7yoilsho	6485	4	of	of	IN
cord-006229-7yoilsho	6485	5	piperacillin	piperacillin	NN
cord-006229-7yoilsho	6485	6	exceeding	exceed	VBG
cord-006229-7yoilsho	6485	7	at	at	RB
cord-006229-7yoilsho	6485	8	least	least	JJS
cord-006229-7yoilsho	6485	9	1xMIC	1xmic	CD
cord-006229-7yoilsho	6485	10	but	but	CC
cord-006229-7yoilsho	6485	11	preferably	preferably	RB
cord-006229-7yoilsho	6485	12	4xMIC	4xmic	CD
cord-006229-7yoilsho	6485	13	over	over	IN
cord-006229-7yoilsho	6485	14	the	the	DT
cord-006229-7yoilsho	6485	15	whole	whole	JJ
cord-006229-7yoilsho	6485	16	dosing	dosing	NN
cord-006229-7yoilsho	6485	17	interval	interval	NN
cord-006229-7yoilsho	6485	18	were	be	VBD
cord-006229-7yoilsho	6485	19	considered	consider	VBN
cord-006229-7yoilsho	6485	20	to	to	TO
cord-006229-7yoilsho	6485	21	be	be	VB
cord-006229-7yoilsho	6485	22	sufficient	sufficient	JJ
cord-006229-7yoilsho	6485	23	for	for	IN
cord-006229-7yoilsho	6485	24	antibiotic	antibiotic	JJ
cord-006229-7yoilsho	6485	25	efficacy	efficacy	NN
cord-006229-7yoilsho	6485	26	(	(	-LRB-
cord-006229-7yoilsho	6485	27	MIC	MIC	NNP
cord-006229-7yoilsho	6485	28	16	16	CD
cord-006229-7yoilsho	6485	29	mg	mg	NNP
cord-006229-7yoilsho	6485	30	/	/	SYM
cord-006229-7yoilsho	6485	31	L	l	NN
cord-006229-7yoilsho	6485	32	for	for	IN
cord-006229-7yoilsho	6485	33	Pseudomonas	Pseudomonas	NNP
cord-006229-7yoilsho	6485	34	spp	spp	NNS
cord-006229-7yoilsho	6485	35	.	.	.
cord-006229-7yoilsho	6486	1	,	,	,
cord-006229-7yoilsho	6486	2	www.eucast.org	www.eucast.org	NN
cord-006229-7yoilsho	6486	3	)	)	-RRB-
cord-006229-7yoilsho	6486	4	.	.	.
cord-006229-7yoilsho	6487	1	Results	result	NNS
cord-006229-7yoilsho	6487	2	:	:	:
cord-006229-7yoilsho	6488	1	The	the	DT
cord-006229-7yoilsho	6488	2	pharmacokinetic	pharmacokinetic	JJ
cord-006229-7yoilsho	6488	3	parameters	parameter	NNS
cord-006229-7yoilsho	6488	4	of	of	IN
cord-006229-7yoilsho	6488	5	total	total	JJ
cord-006229-7yoilsho	6488	6	piperacillin	piperacillin	NN
cord-006229-7yoilsho	6488	7	,	,	,
cord-006229-7yoilsho	6488	8	calculated	calculate	VBN
cord-006229-7yoilsho	6488	9	for	for	IN
cord-006229-7yoilsho	6488	10	each	each	DT
cord-006229-7yoilsho	6488	11	BD	BD	NNP
cord-006229-7yoilsho	6488	12	or	or	CC
cord-006229-7yoilsho	6488	13	ICU	ICU	NNP
cord-006229-7yoilsho	6488	14	patient	patient	NN
cord-006229-7yoilsho	6488	15	using	use	VBG
cord-006229-7yoilsho	6488	16	the	the	DT
cord-006229-7yoilsho	6488	17	concentrations	concentration	NNS
cord-006229-7yoilsho	6488	18	at	at	IN
cord-006229-7yoilsho	6488	19	1	1	CD
cord-006229-7yoilsho	6488	20	,	,	,
cord-006229-7yoilsho	6488	21	4	4	CD
cord-006229-7yoilsho	6488	22	,	,	,
cord-006229-7yoilsho	6488	23	and	and	CC
cord-006229-7yoilsho	6488	24	7.5h	7.5h	LS
cord-006229-7yoilsho	6488	25	,	,	,
cord-006229-7yoilsho	6488	26	were	be	VBD
cord-006229-7yoilsho	6488	27	as	as	IN
cord-006229-7yoilsho	6488	28	follows	follow	VBZ
cord-006229-7yoilsho	6488	29	:	:	:
cord-006229-7yoilsho	6489	1	C	C	NNP
cord-006229-7yoilsho	6489	2	max	max	NNP
cord-006229-7yoilsho	6490	1	69.6±7.9	69.6±7.9	CD
cord-006229-7yoilsho	6491	1	vs.116.3±10.4	vs.116.3±10.4	NNP
cord-006229-7yoilsho	6491	2	mg	mg	NNP
cord-006229-7yoilsho	6491	3	/	/	SYM
cord-006229-7yoilsho	6491	4	L	L	NNP
cord-006229-7yoilsho	6491	5	,	,	,
cord-006229-7yoilsho	6491	6	p<0.05	p<0.05	CD
cord-006229-7yoilsho	6491	7	,	,	,
cord-006229-7yoilsho	6491	8	half	half	JJ
cord-006229-7yoilsho	6491	9	-	-	HYPH
cord-006229-7yoilsho	6491	10	life	life	NN
cord-006229-7yoilsho	6491	11	1.8±0.3	1.8±0.3	CD
cord-006229-7yoilsho	6491	12	vs.	vs.	IN
cord-006229-7yoilsho	6491	13	2.3±0.3h	2.3±0.3h	CD
cord-006229-7yoilsho	6491	14	,	,	,
cord-006229-7yoilsho	6491	15	p>0.05	p>0.05	NNP
cord-006229-7yoilsho	6491	16	,	,	,
cord-006229-7yoilsho	6491	17	clearance	clearance	NN
cord-006229-7yoilsho	6491	18	12.6±1.9	12.6±1.9	CD
cord-006229-7yoilsho	6491	19	vs.	vs.	IN
cord-006229-7yoilsho	6491	20	6.5±0.4	6.5±0.4	NNP
cord-006229-7yoilsho	6491	21	L	L	NNP
cord-006229-7yoilsho	6491	22	/	/	SYM
cord-006229-7yoilsho	6491	23	h	h	NNP
cord-006229-7yoilsho	6491	24	,	,	,
cord-006229-7yoilsho	6491	25	p<0.05	p<0.05	NNP
cord-006229-7yoilsho	6491	26	,	,	,
cord-006229-7yoilsho	6491	27	volume	volume	NN
cord-006229-7yoilsho	6491	28	of	of	IN
cord-006229-7yoilsho	6491	29	distribution	distribution	NN
cord-006229-7yoilsho	6491	30	27.8±2.0	27.8±2.0	CD
cord-006229-7yoilsho	6491	31	vs.	vs.	IN
cord-006229-7yoilsho	6491	32	20.9±1.3L	20.9±1.3l	NN
cord-006229-7yoilsho	6491	33	,	,	,
cord-006229-7yoilsho	6491	34	p<0.05	p<0.05	CD
cord-006229-7yoilsho	6491	35	.	.	.
cord-006229-7yoilsho	6492	1	Free	free	JJ
cord-006229-7yoilsho	6492	2	concentrations	concentration	NNS
cord-006229-7yoilsho	6492	3	(	(	-LRB-
cord-006229-7yoilsho	6492	4	which	which	WDT
cord-006229-7yoilsho	6492	5	were	be	VBD
cord-006229-7yoilsho	6492	6	included	include	VBN
cord-006229-7yoilsho	6492	7	in	in	IN
cord-006229-7yoilsho	6492	8	TDMx	TDMx	NNP
cord-006229-7yoilsho	6492	9	calculations	calculation	NNS
cord-006229-7yoilsho	6492	10	)	)	-RRB-
cord-006229-7yoilsho	6492	11	were	be	VBD
cord-006229-7yoilsho	6492	12	87±2	87±2	CD
cord-006229-7yoilsho	6492	13	vs.	vs.	IN
cord-006229-7yoilsho	6492	14	81±2	81±2	CD
cord-006229-7yoilsho	6492	15	%	%	NN
cord-006229-7yoilsho	6492	16	(	(	-LRB-
cord-006229-7yoilsho	6492	17	p<0.05	p<0.05	CD
cord-006229-7yoilsho	6492	18	)	)	-RRB-
cord-006229-7yoilsho	6492	19	of	of	IN
cord-006229-7yoilsho	6492	20	total	total	JJ
cord-006229-7yoilsho	6492	21	concentrations	concentration	NNS
cord-006229-7yoilsho	6492	22	.	.	.
cord-006229-7yoilsho	6493	1	Duration	duration	NN
cord-006229-7yoilsho	6493	2	per	per	IN
cord-006229-7yoilsho	6493	3	day	day	NN
cord-006229-7yoilsho	6493	4	while	while	IN
cord-006229-7yoilsho	6493	5	concentrations	concentration	NNS
cord-006229-7yoilsho	6493	6	exceeded	exceed	VBD
cord-006229-7yoilsho	6493	7	1xMIC	1xmic	CD
cord-006229-7yoilsho	6493	8	(	(	-LRB-
cord-006229-7yoilsho	6493	9	15.6±1.9	15.6±1.9	CD
cord-006229-7yoilsho	6493	10	vs.	vs.	CC
cord-006229-7yoilsho	6493	11	22.0±1.1h	22.0±1.1h	CD
cord-006229-7yoilsho	6493	12	,	,	,
cord-006229-7yoilsho	6493	13	p<0.05	p<0.05	CD
cord-006229-7yoilsho	6493	14	)	)	-RRB-
cord-006229-7yoilsho	6493	15	or	or	CC
cord-006229-7yoilsho	6493	16	4xMIC	4xMIC	NNP
cord-006229-7yoilsho	6493	17	(	(	-LRB-
cord-006229-7yoilsho	6493	18	5.4±1.3	5.4±1.3	CD
cord-006229-7yoilsho	6493	19	vs.	vs.	IN
cord-006229-7yoilsho	6493	20	9	9	CD
cord-006229-7yoilsho	6493	21	.4±0.7h	.4±0.7h	NNP
cord-006229-7yoilsho	6493	22	,	,	,
cord-006229-7yoilsho	6493	23	p<0.05	p<0.05	CD
cord-006229-7yoilsho	6493	24	)	)	-RRB-
cord-006229-7yoilsho	6493	25	were	be	VBD
cord-006229-7yoilsho	6493	26	lower	low	JJR
cord-006229-7yoilsho	6493	27	in	in	IN
cord-006229-7yoilsho	6493	28	BD	BD	NNP
cord-006229-7yoilsho	6493	29	than	than	IN
cord-006229-7yoilsho	6493	30	in	in	IN
cord-006229-7yoilsho	6493	31	ICU	ICU	NNP
cord-006229-7yoilsho	6493	32	patients	patient	NNS
cord-006229-7yoilsho	6493	33	.	.	.
cord-006229-7yoilsho	6494	1	Moreover	moreover	RB
cord-006229-7yoilsho	6494	2	,	,	,
cord-006229-7yoilsho	6494	3	TDMx	TDMx	NNPS
cord-006229-7yoilsho	6494	4	simulations	simulation	NNS
cord-006229-7yoilsho	6494	5	predicted	predict	VBD
cord-006229-7yoilsho	6494	6	that	that	IN
cord-006229-7yoilsho	6494	7	the	the	DT
cord-006229-7yoilsho	6494	8	duration	duration	NN
cord-006229-7yoilsho	6494	9	per	per	IN
cord-006229-7yoilsho	6494	10	day	day	NN
cord-006229-7yoilsho	6494	11	for	for	IN
cord-006229-7yoilsho	6494	12	4xMIC	4xmic	CD
cord-006229-7yoilsho	6494	13	could	could	MD
cord-006229-7yoilsho	6494	14	be	be	VB
cord-006229-7yoilsho	6494	15	enhanced	enhance	VBN
cord-006229-7yoilsho	6494	16	to	to	IN
cord-006229-7yoilsho	6494	17	16.2±1.5h	16.2±1.5h	CD
cord-006229-7yoilsho	6494	18	if	if	IN
cord-006229-7yoilsho	6494	19	the	the	DT
cord-006229-7yoilsho	6494	20	piperacillin	piperacillin	NN
cord-006229-7yoilsho	6494	21	amount	amount	NN
cord-006229-7yoilsho	6494	22	will	will	MD
cord-006229-7yoilsho	6494	23	be	be	VB
cord-006229-7yoilsho	6494	24	increased	increase	VBN
cord-006229-7yoilsho	6494	25	to	to	IN
cord-006229-7yoilsho	6494	26	4x8	4x8	CD
cord-006229-7yoilsho	6494	27	g	g	NN
cord-006229-7yoilsho	6494	28	/	/	SYM
cord-006229-7yoilsho	6494	29	d	d	NN
cord-006229-7yoilsho	6494	30	and	and	CC
cord-006229-7yoilsho	6494	31	the	the	DT
cord-006229-7yoilsho	6494	32	infusion	infusion	NN
cord-006229-7yoilsho	6494	33	duration	duration	NN
cord-006229-7yoilsho	6494	34	to	to	IN
cord-006229-7yoilsho	6494	35	3h	3h	CD
cord-006229-7yoilsho	6494	36	.	.	.
cord-006229-7yoilsho	6495	1	Pharmacokinetic	pharmacokinetic	JJ
cord-006229-7yoilsho	6495	2	parameters	parameter	NNS
cord-006229-7yoilsho	6495	3	have	have	VBP
cord-006229-7yoilsho	6495	4	,	,	,
cord-006229-7yoilsho	6495	5	however	however	RB
cord-006229-7yoilsho	6495	6	,	,	,
cord-006229-7yoilsho	6495	7	to	to	TO
cord-006229-7yoilsho	6495	8	be	be	VB
cord-006229-7yoilsho	6495	9	determined	determine	VBN
cord-006229-7yoilsho	6495	10	in	in	IN
cord-006229-7yoilsho	6495	11	a	a	DT
cord-006229-7yoilsho	6495	12	pilot	pilot	NN
cord-006229-7yoilsho	6495	13	study	study	NN
cord-006229-7yoilsho	6495	14	with	with	IN
cord-006229-7yoilsho	6495	15	BD	BD	NNP
cord-006229-7yoilsho	6495	16	patients	patient	NNS
cord-006229-7yoilsho	6495	17	to	to	TO
cord-006229-7yoilsho	6495	18	ensure	ensure	VB
cord-006229-7yoilsho	6495	19	predicted	predict	VBN
cord-006229-7yoilsho	6495	20	values	value	NNS
cord-006229-7yoilsho	6495	21	.	.	.
cord-006229-7yoilsho	6496	1	Conclusions	conclusion	NNS
cord-006229-7yoilsho	6496	2	:	:	:
cord-006229-7yoilsho	6497	1	Standard	standard	JJ
cord-006229-7yoilsho	6497	2	dosage	dosage	NN
cord-006229-7yoilsho	6497	3	regimens	regimen	NNS
cord-006229-7yoilsho	6497	4	for	for	IN
cord-006229-7yoilsho	6497	5	piperacillin	piperacillin	NNP
cord-006229-7yoilsho	6497	6	/	/	SYM
cord-006229-7yoilsho	6497	7	tazobactam	tazobactam	NNS
cord-006229-7yoilsho	6497	8	could	could	MD
cord-006229-7yoilsho	6497	9	result	result	VB
cord-006229-7yoilsho	6497	10	in	in	IN
cord-006229-7yoilsho	6497	11	suboptimal	suboptimal	JJ
cord-006229-7yoilsho	6497	12	plasma	plasma	NN
cord-006229-7yoilsho	6497	13	concentrations	concentration	NNS
cord-006229-7yoilsho	6497	14	of	of	IN
cord-006229-7yoilsho	6497	15	piperacillin	piperacillin	NN
cord-006229-7yoilsho	6497	16	in	in	IN
cord-006229-7yoilsho	6497	17	BD	BD	NNP
cord-006229-7yoilsho	6497	18	patients	patient	NNS
cord-006229-7yoilsho	6497	19	as	as	RB
cord-006229-7yoilsho	6497	20	well	well	RB
cord-006229-7yoilsho	6497	21	as	as	IN
cord-006229-7yoilsho	6497	22	in	in	IN
cord-006229-7yoilsho	6497	23	ICU	ICU	NNP
cord-006229-7yoilsho	6497	24	patients	patient	NNS
cord-006229-7yoilsho	6497	25	.	.	.
cord-006229-7yoilsho	6498	1	Drug	drug	NN
cord-006229-7yoilsho	6498	2	monitoring	monitoring	NN
cord-006229-7yoilsho	6498	3	and	and	CC
cord-006229-7yoilsho	6498	4	TDMx	TDMx	NNPS
cord-006229-7yoilsho	6498	5	simulation	simulation	NN
cord-006229-7yoilsho	6498	6	of	of	IN
cord-006229-7yoilsho	6498	7	kinetic	kinetic	JJ
cord-006229-7yoilsho	6498	8	parameters	parameter	NNS
cord-006229-7yoilsho	6498	9	may	may	MD
cord-006229-7yoilsho	6498	10	easily	easily	RB
cord-006229-7yoilsho	6498	11	help	help	VB
cord-006229-7yoilsho	6498	12	to	to	TO
cord-006229-7yoilsho	6498	13	improve	improve	VB
cord-006229-7yoilsho	6498	14	piperacillin	piperacillin	NN
cord-006229-7yoilsho	6498	15	treatment	treatment	NN
cord-006229-7yoilsho	6498	16	in	in	IN
cord-006229-7yoilsho	6498	17	BD	BD	NNP
cord-006229-7yoilsho	6498	18	patients	patient	NNS
cord-006229-7yoilsho	6498	19	.	.	.
cord-006229-7yoilsho	6499	1	Background	background	NN
cord-006229-7yoilsho	6499	2	:	:	:
cord-006229-7yoilsho	6500	1	High	high	JJ
cord-006229-7yoilsho	6500	2	dose	dose	NN
cord-006229-7yoilsho	6500	3	methotrexate	methotrexate	NNP
cord-006229-7yoilsho	6500	4	(	(	-LRB-
cord-006229-7yoilsho	6500	5	HD	HD	NNP
cord-006229-7yoilsho	6500	6	MTX	MTX	NNP
cord-006229-7yoilsho	6500	7	)	)	-RRB-
cord-006229-7yoilsho	6500	8	,	,	,
cord-006229-7yoilsho	6500	9	defined	define	VBN
cord-006229-7yoilsho	6500	10	as	as	IN
cord-006229-7yoilsho	6500	11	>	>	$
cord-006229-7yoilsho	6500	12	1000	1000	CD
cord-006229-7yoilsho	6500	13	mg	mg	NNP
cord-006229-7yoilsho	6500	14	MTX	MTX	NNP
cord-006229-7yoilsho	6500	15	/	/	SYM
cord-006229-7yoilsho	6500	16	m	m	NNP
cord-006229-7yoilsho	6500	17	2	2	CD
cord-006229-7yoilsho	6500	18	bodysurface	bodysurface	NNP
cord-006229-7yoilsho	6500	19	-	-	HYPH
cord-006229-7yoilsho	6500	20	area	area	NN
cord-006229-7yoilsho	6500	21	(	(	-LRB-
cord-006229-7yoilsho	6500	22	BSA	BSA	NNP
cord-006229-7yoilsho	6500	23	)	)	-RRB-
cord-006229-7yoilsho	6500	24	is	be	VBZ
cord-006229-7yoilsho	6500	25	used	use	VBN
cord-006229-7yoilsho	6500	26	in	in	IN
cord-006229-7yoilsho	6500	27	children	child	NNS
cord-006229-7yoilsho	6500	28	to	to	TO
cord-006229-7yoilsho	6500	29	treat	treat	VB
cord-006229-7yoilsho	6500	30	a	a	DT
cord-006229-7yoilsho	6500	31	variety	variety	NN
cord-006229-7yoilsho	6500	32	of	of	IN
cord-006229-7yoilsho	6500	33	malignant	malignant	JJ
cord-006229-7yoilsho	6500	34	diseases	disease	NNS
cord-006229-7yoilsho	6500	35	since	since	IN
cord-006229-7yoilsho	6500	36	the	the	DT
cord-006229-7yoilsho	6500	37	1950s	1950s	CD
cord-006229-7yoilsho	6500	38	.	.	.
cord-006229-7yoilsho	6501	1	Clinicians	clinician	NNS
cord-006229-7yoilsho	6501	2	observe	observe	VBP
cord-006229-7yoilsho	6501	3	relevant	relevant	JJ
cord-006229-7yoilsho	6501	4	rates	rate	NNS
cord-006229-7yoilsho	6501	5	of	of	IN
cord-006229-7yoilsho	6501	6	severe	severe	JJ
cord-006229-7yoilsho	6501	7	unwanted	unwanted	JJ
cord-006229-7yoilsho	6501	8	side	side	NN
cord-006229-7yoilsho	6501	9	effects	effect	NNS
cord-006229-7yoilsho	6501	10	.	.	.
cord-006229-7yoilsho	6502	1	Identifying	identify	VBG
cord-006229-7yoilsho	6502	2	patients	patient	NNS
cord-006229-7yoilsho	6502	3	having	have	VBG
cord-006229-7yoilsho	6502	4	an	an	DT
cord-006229-7yoilsho	6502	5	increased	increase	VBN
cord-006229-7yoilsho	6502	6	risk	risk	NN
cord-006229-7yoilsho	6502	7	for	for	IN
cord-006229-7yoilsho	6502	8	toxicity	toxicity	NN
cord-006229-7yoilsho	6502	9	due	due	IN
cord-006229-7yoilsho	6502	10	to	to	IN
cord-006229-7yoilsho	6502	11	altered	alter	VBN
cord-006229-7yoilsho	6502	12	MTX	MTX	NNP
cord-006229-7yoilsho	6502	13	pharmacokinetics	pharmacokinetic	NNS
cord-006229-7yoilsho	6502	14	is	be	VBZ
cord-006229-7yoilsho	6502	15	urgently	urgently	RB
cord-006229-7yoilsho	6502	16	needed	need	VBN
cord-006229-7yoilsho	6502	17	.	.	.
cord-006229-7yoilsho	6503	1	We	-PRON-	PRP
cord-006229-7yoilsho	6503	2	aim	aim	VBP
cord-006229-7yoilsho	6503	3	to	to	TO
cord-006229-7yoilsho	6503	4	develop	develop	VB
cord-006229-7yoilsho	6503	5	and	and	CC
cord-006229-7yoilsho	6503	6	evaluate	evaluate	VB
cord-006229-7yoilsho	6503	7	a	a	DT
cord-006229-7yoilsho	6503	8	Physiology	physiology	NN
cord-006229-7yoilsho	6503	9	-	-	HYPH
cord-006229-7yoilsho	6503	10	based	base	VBN
cord-006229-7yoilsho	6503	11	Pharmacokinetic	Pharmacokinetic	NNP
cord-006229-7yoilsho	6503	12	(	(	-LRB-
cord-006229-7yoilsho	6503	13	PBPK	PBPK	NNP
cord-006229-7yoilsho	6503	14	)	)	-RRB-
cord-006229-7yoilsho	6503	15	Model	Model	NNP
cord-006229-7yoilsho	6503	16	for	for	IN
cord-006229-7yoilsho	6503	17	HD	HD	NNP
cord-006229-7yoilsho	6503	18	MTX	MTX	NNP
cord-006229-7yoilsho	6503	19	in	in	IN
cord-006229-7yoilsho	6503	20	children	child	NNS
cord-006229-7yoilsho	6503	21	using	use	VBG
cord-006229-7yoilsho	6504	1	PK	PK	NNP
cord-006229-7yoilsho	6504	2	-	-	HYPH
cord-006229-7yoilsho	6504	3	Sim	Sim	NNP
cord-006229-7yoilsho	6504	4	®	®	.
cord-006229-7yoilsho	6504	5	(	(	-LRB-
cord-006229-7yoilsho	6504	6	Bayer	Bayer	NNP
cord-006229-7yoilsho	6504	7	Technology	Technology	NNP
cord-006229-7yoilsho	6504	8	Services	Services	NNP
cord-006229-7yoilsho	6504	9	GmbH	GmbH	NNP
cord-006229-7yoilsho	6504	10	,	,	,
cord-006229-7yoilsho	6504	11	Leverkusen	Leverkusen	NNP
cord-006229-7yoilsho	6504	12	,	,	,
cord-006229-7yoilsho	6504	13	Germany	Germany	NNP
cord-006229-7yoilsho	6504	14	)	)	-RRB-
cord-006229-7yoilsho	6504	15	with	with	IN
cord-006229-7yoilsho	6504	16	a	a	DT
cord-006229-7yoilsho	6504	17	special	special	JJ
cord-006229-7yoilsho	6504	18	emphasize	emphasize	NN
cord-006229-7yoilsho	6504	19	on	on	IN
cord-006229-7yoilsho	6504	20	relevant	relevant	JJ
cord-006229-7yoilsho	6504	21	covariates	covariate	NNS
cord-006229-7yoilsho	6504	22	.	.	.
cord-006229-7yoilsho	6505	1	Methods	method	NNS
cord-006229-7yoilsho	6505	2	:	:	:
cord-006229-7yoilsho	6505	3	In	in	IN
cord-006229-7yoilsho	6505	4	this	this	DT
cord-006229-7yoilsho	6505	5	non	non	JJ
cord-006229-7yoilsho	6505	6	-	-	JJ
cord-006229-7yoilsho	6505	7	interventional	interventional	JJ
cord-006229-7yoilsho	6505	8	observational	observational	JJ
cord-006229-7yoilsho	6505	9	study	study	NN
cord-006229-7yoilsho	6505	10	,	,	,
cord-006229-7yoilsho	6505	11	children	child	NNS
cord-006229-7yoilsho	6505	12	receiving	receive	VBG
cord-006229-7yoilsho	6505	13	HD	HD	NNP
cord-006229-7yoilsho	6505	14	MTX	MTX	NNP
cord-006229-7yoilsho	6505	15	intravenously	intravenously	RB
cord-006229-7yoilsho	6505	16	at	at	IN
cord-006229-7yoilsho	6505	17	two	two	CD
cord-006229-7yoilsho	6505	18	major	major	JJ
cord-006229-7yoilsho	6505	19	German	german	JJ
cord-006229-7yoilsho	6505	20	pediatric	pediatric	JJ
cord-006229-7yoilsho	6505	21	oncology	oncology	NN
cord-006229-7yoilsho	6505	22	departments	department	NNS
cord-006229-7yoilsho	6505	23	during	during	IN
cord-006229-7yoilsho	6505	24	the	the	DT
cord-006229-7yoilsho	6505	25	years	year	NNS
cord-006229-7yoilsho	6505	26	2004	2004	CD
cord-006229-7yoilsho	6505	27	-	-	SYM
cord-006229-7yoilsho	6505	28	2009	2009	CD
cord-006229-7yoilsho	6505	29	were	be	VBD
cord-006229-7yoilsho	6505	30	included	include	VBN
cord-006229-7yoilsho	6505	31	if	if	IN
cord-006229-7yoilsho	6505	32	at	at	RB
cord-006229-7yoilsho	6505	33	least	least	RBS
cord-006229-7yoilsho	6505	34	one	one	CD
cord-006229-7yoilsho	6505	35	MTX	MTX	NNP
cord-006229-7yoilsho	6505	36	serum	serum	NN
cord-006229-7yoilsho	6505	37	level	level	NN
cord-006229-7yoilsho	6505	38	(	(	-LRB-
cord-006229-7yoilsho	6505	39	MTX	MTX	NNP
cord-006229-7yoilsho	6505	40	-	-	HYPH
cord-006229-7yoilsho	6505	41	SL	SL	NNP
cord-006229-7yoilsho	6505	42	)	)	-RRB-
cord-006229-7yoilsho	6505	43	was	be	VBD
cord-006229-7yoilsho	6505	44	determined	determine	VBN
cord-006229-7yoilsho	6505	45	during	during	IN
cord-006229-7yoilsho	6505	46	clinical	clinical	JJ
cord-006229-7yoilsho	6505	47	routine	routine	NN
cord-006229-7yoilsho	6505	48	.	.	.
cord-006229-7yoilsho	6506	1	29	29	CD
cord-006229-7yoilsho	6506	2	Patients	patient	NNS
cord-006229-7yoilsho	6506	3	aged	aged	JJ
cord-006229-7yoilsho	6506	4	2	2	CD
cord-006229-7yoilsho	6506	5	-	-	SYM
cord-006229-7yoilsho	6506	6	18	18	CD
cord-006229-7yoilsho	6506	7	years	year	NNS
cord-006229-7yoilsho	6506	8	(	(	-LRB-
cord-006229-7yoilsho	6506	9	male	male	NN
cord-006229-7yoilsho	6506	10	=	=	SYM
cord-006229-7yoilsho	6506	11	19	19	CD
cord-006229-7yoilsho	6506	12	,	,	,
cord-006229-7yoilsho	6506	13	female	female	JJ
cord-006229-7yoilsho	6506	14	=	=	SYM
cord-006229-7yoilsho	6506	15	10	10	CD
cord-006229-7yoilsho	6506	16	)	)	-RRB-
cord-006229-7yoilsho	6506	17	with	with	IN
cord-006229-7yoilsho	6506	18	following	follow	VBG
cord-006229-7yoilsho	6506	19	diagnoses	diagnosis	NNS
cord-006229-7yoilsho	6506	20	were	be	VBD
cord-006229-7yoilsho	6506	21	included	include	VBN
cord-006229-7yoilsho	6506	22	:	:	:
cord-006229-7yoilsho	6506	23	acute	acute	JJ
cord-006229-7yoilsho	6506	24	lymphoblastic	lymphoblastic	JJ
cord-006229-7yoilsho	6506	25	leukemia	leukemia	NN
cord-006229-7yoilsho	6506	26	,	,	,
cord-006229-7yoilsho	6506	27	Non	Non	NNP
cord-006229-7yoilsho	6506	28	-	-	NNP
cord-006229-7yoilsho	6506	29	Hodgkin	Hodgkin	NNP
cord-006229-7yoilsho	6506	30	Lymphoma	Lymphoma	NNP
cord-006229-7yoilsho	6506	31	,	,	,
cord-006229-7yoilsho	6506	32	Burkitt	Burkitt	NNP
cord-006229-7yoilsho	6506	33	Lymphoma	Lymphoma	NNP
cord-006229-7yoilsho	6506	34	,	,	,
cord-006229-7yoilsho	6506	35	brain	brain	NN
cord-006229-7yoilsho	6506	36	stem	stem	NN
cord-006229-7yoilsho	6506	37	glioma	glioma	NN
cord-006229-7yoilsho	6506	38	and	and	CC
cord-006229-7yoilsho	6506	39	glioblastoma	glioblastoma	NN
cord-006229-7yoilsho	6506	40	multiforme	multiforme	NN
cord-006229-7yoilsho	6506	41	.	.	.
cord-006229-7yoilsho	6507	1	In	in	IN
cord-006229-7yoilsho	6507	2	total	total	NN
cord-006229-7yoilsho	6507	3	,	,	,
cord-006229-7yoilsho	6507	4	103	103	CD
cord-006229-7yoilsho	6507	5	MTX	MTX	NNP
cord-006229-7yoilsho	6507	6	treatment	treatment	NN
cord-006229-7yoilsho	6507	7	cycles	cycle	NNS
cord-006229-7yoilsho	6507	8	corresponding	correspond	VBG
cord-006229-7yoilsho	6507	9	to	to	IN
cord-006229-7yoilsho	6507	10	300	300	CD
cord-006229-7yoilsho	6507	11	MTX	MTX	NNP
cord-006229-7yoilsho	6507	12	-	-	HYPH
cord-006229-7yoilsho	6507	13	SL	SL	NNP
cord-006229-7yoilsho	6507	14	were	be	VBD
cord-006229-7yoilsho	6507	15	used	use	VBN
cord-006229-7yoilsho	6507	16	in	in	IN
cord-006229-7yoilsho	6507	17	this	this	DT
cord-006229-7yoilsho	6507	18	study	study	NN
cord-006229-7yoilsho	6507	19	.	.	.
cord-006229-7yoilsho	6508	1	Patients	patient	NNS
cord-006229-7yoilsho	6508	2	were	be	VBD
cord-006229-7yoilsho	6508	3	randomized	randomize	VBN
cord-006229-7yoilsho	6508	4	into	into	IN
cord-006229-7yoilsho	6508	5	two	two	CD
cord-006229-7yoilsho	6508	6	patient	patient	NN
cord-006229-7yoilsho	6508	7	sets	set	NNS
cord-006229-7yoilsho	6508	8	(	(	-LRB-
cord-006229-7yoilsho	6508	9	training	training	NN
cord-006229-7yoilsho	6508	10	set	set	NN
cord-006229-7yoilsho	6508	11	and	and	CC
cord-006229-7yoilsho	6508	12	test	test	NN
cord-006229-7yoilsho	6508	13	set	set	VBN
cord-006229-7yoilsho	6508	14	)	)	-RRB-
cord-006229-7yoilsho	6508	15	.	.	.
cord-006229-7yoilsho	6509	1	Based	base	VBN
cord-006229-7yoilsho	6509	2	on	on	IN
cord-006229-7yoilsho	6509	3	literature	literature	NN
cord-006229-7yoilsho	6509	4	data	datum	NNS
cord-006229-7yoilsho	6509	5	,	,	,
cord-006229-7yoilsho	6509	6	MTX	MTX	NNP
cord-006229-7yoilsho	6509	7	PBPK	PBPK	NNP
cord-006229-7yoilsho	6509	8	-	-	HYPH
cord-006229-7yoilsho	6509	9	models	model	NNS
cord-006229-7yoilsho	6509	10	were	be	VBD
cord-006229-7yoilsho	6509	11	developed	develop	VBN
cord-006229-7yoilsho	6509	12	and	and	CC
cord-006229-7yoilsho	6509	13	slightly	slightly	RB
cord-006229-7yoilsho	6509	14	adapted	adapt	VBN
cord-006229-7yoilsho	6509	15	taking	take	VBG
cord-006229-7yoilsho	6509	16	into	into	IN
cord-006229-7yoilsho	6509	17	account	account	NN
cord-006229-7yoilsho	6510	1	mean	mean	VB
cord-006229-7yoilsho	6510	2	relative	relative	JJ
cord-006229-7yoilsho	6510	3	deviation	deviation	NN
cord-006229-7yoilsho	6510	4	(	(	-LRB-
cord-006229-7yoilsho	6510	5	MRD	MRD	NNP
cord-006229-7yoilsho	6510	6	)	)	-RRB-
cord-006229-7yoilsho	6510	7	and	and	CC
cord-006229-7yoilsho	6510	8	bias	bias	NN
cord-006229-7yoilsho	6510	9	of	of	IN
cord-006229-7yoilsho	6510	10	predicted	predict	VBN
cord-006229-7yoilsho	6510	11	versus	versus	IN
cord-006229-7yoilsho	6510	12	observed	observed	JJ
cord-006229-7yoilsho	6510	13	MTX	MTX	NNP
cord-006229-7yoilsho	6510	14	-	-	HYPH
cord-006229-7yoilsho	6510	15	SL	SL	NNP
cord-006229-7yoilsho	6510	16	of	of	IN
cord-006229-7yoilsho	6510	17	the	the	DT
cord-006229-7yoilsho	6510	18	training	training	NN
cord-006229-7yoilsho	6510	19	set	set	NN
cord-006229-7yoilsho	6510	20	.	.	.
cord-006229-7yoilsho	6511	1	The	the	DT
cord-006229-7yoilsho	6511	2	PBPK	PBPK	NNP
cord-006229-7yoilsho	6511	3	model	model	NN
cord-006229-7yoilsho	6511	4	with	with	IN
cord-006229-7yoilsho	6511	5	the	the	DT
cord-006229-7yoilsho	6511	6	lowest	low	JJS
cord-006229-7yoilsho	6511	7	MRD	MRD	NNP
cord-006229-7yoilsho	6511	8	and	and	CC
cord-006229-7yoilsho	6511	9	bias	bias	NN
cord-006229-7yoilsho	6511	10	was	be	VBD
cord-006229-7yoilsho	6511	11	chosen	choose	VBN
cord-006229-7yoilsho	6511	12	and	and	CC
cord-006229-7yoilsho	6511	13	finally	finally	RB
cord-006229-7yoilsho	6511	14	evaluated	evaluate	VBN
cord-006229-7yoilsho	6511	15	using	use	VBG
cord-006229-7yoilsho	6511	16	the	the	DT
cord-006229-7yoilsho	6511	17	test	test	NN
cord-006229-7yoilsho	6511	18	set	set	VBN
cord-006229-7yoilsho	6511	19	.	.	.
cord-006229-7yoilsho	6512	1	The	the	DT
cord-006229-7yoilsho	6512	2	impact	impact	NN
cord-006229-7yoilsho	6512	3	of	of	IN
cord-006229-7yoilsho	6512	4	the	the	DT
cord-006229-7yoilsho	6512	5	covariates	covariate	NNS
cord-006229-7yoilsho	6512	6	urine	urine	NN
cord-006229-7yoilsho	6512	7	pH	pH	NNP
cord-006229-7yoilsho	6513	1	<	<	NNP
cord-006229-7yoilsho	6513	2	6.5	6.5	CD
cord-006229-7yoilsho	6513	3	,	,	,
cord-006229-7yoilsho	6513	4	trimethoprime	trimethoprime	NNP
cord-006229-7yoilsho	6513	5	/	/	SYM
cord-006229-7yoilsho	6513	6	sulfamethoxazole	sulfamethoxazole	NN
cord-006229-7yoilsho	6513	7	,	,	,
cord-006229-7yoilsho	6513	8	proton	proton	NN
cord-006229-7yoilsho	6513	9	-	-	HYPH
cord-006229-7yoilsho	6513	10	pump	pump	NN
cord-006229-7yoilsho	6513	11	-	-	HYPH
cord-006229-7yoilsho	6513	12	inhibitors	inhibitor	NNS
cord-006229-7yoilsho	6513	13	,	,	,
cord-006229-7yoilsho	6513	14	non	non	JJ
cord-006229-7yoilsho	6513	15	-	-	JJ
cord-006229-7yoilsho	6513	16	steroidal	steroidal	JJ
cord-006229-7yoilsho	6513	17	anti	anti	JJ
cord-006229-7yoilsho	6513	18	-	-	JJ
cord-006229-7yoilsho	6513	19	inflammatory	inflammatory	JJ
cord-006229-7yoilsho	6513	20	drugs	drug	NNS
cord-006229-7yoilsho	6513	21	and	and	CC
cord-006229-7yoilsho	6513	22	ß	ß	NN
cord-006229-7yoilsho	6513	23	-	-	HYPH
cord-006229-7yoilsho	6513	24	lactam	lactam	NN
cord-006229-7yoilsho	6513	25	antibiotics	antibiotic	NNS
cord-006229-7yoilsho	6513	26	on	on	IN
cord-006229-7yoilsho	6513	27	the	the	DT
cord-006229-7yoilsho	6513	28	prediction	prediction	NN
cord-006229-7yoilsho	6513	29	quality	quality	NN
cord-006229-7yoilsho	6513	30	was	be	VBD
cord-006229-7yoilsho	6513	31	assessed	assess	VBN
cord-006229-7yoilsho	6513	32	using	use	VBG
cord-006229-7yoilsho	6513	33	the	the	DT
cord-006229-7yoilsho	6513	34	Mann	Mann	NNP
cord-006229-7yoilsho	6513	35	-	-	HYPH
cord-006229-7yoilsho	6513	36	Whitney	Whitney	NNP
cord-006229-7yoilsho	6513	37	U	U	NNP
cord-006229-7yoilsho	6513	38	test	test	NN
cord-006229-7yoilsho	6513	39	.	.	.
cord-006229-7yoilsho	6514	1	Ochratoxin	Ochratoxin	NNP
cord-006229-7yoilsho	6514	2	A	A	NNP
cord-006229-7yoilsho	6514	3	(	(	-LRB-
cord-006229-7yoilsho	6514	4	OTA	ota	NN
cord-006229-7yoilsho	6514	5	)	)	-RRB-
cord-006229-7yoilsho	6514	6	is	be	VBZ
cord-006229-7yoilsho	6514	7	a	a	DT
cord-006229-7yoilsho	6514	8	wide	wide	JJ
cord-006229-7yoilsho	6514	9	-	-	HYPH
cord-006229-7yoilsho	6514	10	spread	spread	NN
cord-006229-7yoilsho	6514	11	food	food	NN
cord-006229-7yoilsho	6514	12	contaminant	contaminant	NN
cord-006229-7yoilsho	6514	13	and	and	CC
cord-006229-7yoilsho	6514	14	one	one	CD
cord-006229-7yoilsho	6514	15	of	of	IN
cord-006229-7yoilsho	6514	16	the	the	DT
cord-006229-7yoilsho	6514	17	most	most	RBS
cord-006229-7yoilsho	6514	18	potent	potent	JJ
cord-006229-7yoilsho	6514	19	renal	renal	JJ
cord-006229-7yoilsho	6514	20	carcinogens	carcinogen	NNS
cord-006229-7yoilsho	6514	21	[	[	-LRB-
cord-006229-7yoilsho	6514	22	1	1	CD
cord-006229-7yoilsho	6514	23	]	]	-RRB-
cord-006229-7yoilsho	6514	24	.	.	.
cord-006229-7yoilsho	6515	1	Recent	recent	JJ
cord-006229-7yoilsho	6515	2	data	datum	NNS
cord-006229-7yoilsho	6515	3	by	by	IN
cord-006229-7yoilsho	6515	4	our	-PRON-	PRP$
cord-006229-7yoilsho	6515	5	group	group	NN
cord-006229-7yoilsho	6515	6	demonstrate	demonstrate	VBP
cord-006229-7yoilsho	6515	7	that	that	IN
cord-006229-7yoilsho	6515	8	OTA	OTA	NNP
cord-006229-7yoilsho	6515	9	inhibits	inhibit	VBZ
cord-006229-7yoilsho	6515	10	histone	histone	NN
cord-006229-7yoilsho	6515	11	acetyltransferases	acetyltransferase	NNS
cord-006229-7yoilsho	6515	12	(	(	-LRB-
cord-006229-7yoilsho	6515	13	HATs	HATs	NNP
cord-006229-7yoilsho	6515	14	)	)	-RRB-
cord-006229-7yoilsho	6515	15	,	,	,
cord-006229-7yoilsho	6515	16	thereby	thereby	RB
cord-006229-7yoilsho	6515	17	causing	cause	VBG
cord-006229-7yoilsho	6515	18	a	a	DT
cord-006229-7yoilsho	6515	19	global	global	JJ
cord-006229-7yoilsho	6515	20	reduction	reduction	NN
cord-006229-7yoilsho	6515	21	of	of	IN
cord-006229-7yoilsho	6515	22	lysine	lysine	NN
cord-006229-7yoilsho	6515	23	acetylation	acetylation	NN
cord-006229-7yoilsho	6515	24	of	of	IN
cord-006229-7yoilsho	6515	25	histones	histone	NNS
cord-006229-7yoilsho	6515	26	and	and	CC
cord-006229-7yoilsho	6515	27	non	non	JJ
cord-006229-7yoilsho	6515	28	-	-	JJ
cord-006229-7yoilsho	6515	29	histone	histone	JJ
cord-006229-7yoilsho	6515	30	proteins	protein	NNS
cord-006229-7yoilsho	6515	31	[	[	-LRB-
cord-006229-7yoilsho	6515	32	2	2	CD
cord-006229-7yoilsho	6515	33	]	]	-RRB-
cord-006229-7yoilsho	6515	34	.	.	.
cord-006229-7yoilsho	6516	1	Based	base	VBN
cord-006229-7yoilsho	6516	2	on	on	IN
cord-006229-7yoilsho	6516	3	these	these	DT
cord-006229-7yoilsho	6516	4	findings	finding	NNS
cord-006229-7yoilsho	6516	5	and	and	CC
cord-006229-7yoilsho	6516	6	the	the	DT
cord-006229-7yoilsho	6516	7	importance	importance	NN
cord-006229-7yoilsho	6516	8	of	of	IN
cord-006229-7yoilsho	6516	9	specific	specific	JJ
cord-006229-7yoilsho	6516	10	histone	histone	JJ
cord-006229-7yoilsho	6516	11	acetylation	acetylation	NN
cord-006229-7yoilsho	6516	12	marks	mark	NNS
cord-006229-7yoilsho	6516	13	in	in	IN
cord-006229-7yoilsho	6516	14	regulating	regulate	VBG
cord-006229-7yoilsho	6516	15	gene	gene	NN
cord-006229-7yoilsho	6516	16	transcription	transcription	NN
cord-006229-7yoilsho	6516	17	[	[	-LRB-
cord-006229-7yoilsho	6516	18	3	3	CD
cord-006229-7yoilsho	6516	19	]	]	-RRB-
cord-006229-7yoilsho	6516	20	,	,	,
cord-006229-7yoilsho	6516	21	we	-PRON-	PRP
cord-006229-7yoilsho	6516	22	speculated	speculate	VBD
cord-006229-7yoilsho	6516	23	that	that	IN
cord-006229-7yoilsho	6516	24	repression	repression	NN
cord-006229-7yoilsho	6516	25	of	of	IN
cord-006229-7yoilsho	6516	26	gene	gene	NN
cord-006229-7yoilsho	6516	27	expression	expression	NN
cord-006229-7yoilsho	6516	28	as	as	IN
cord-006229-7yoilsho	6516	29	the	the	DT
cord-006229-7yoilsho	6516	30	predominant	predominant	JJ
cord-006229-7yoilsho	6516	31	transcriptional	transcriptional	JJ
cord-006229-7yoilsho	6516	32	response	response	NN
cord-006229-7yoilsho	6516	33	to	to	IN
cord-006229-7yoilsho	6516	34	OTA	OTA	NNP
cord-006229-7yoilsho	6516	35	[	[	-LRB-
cord-006229-7yoilsho	6516	36	4	4	CD
cord-006229-7yoilsho	6516	37	,	,	,
cord-006229-7yoilsho	6516	38	5	5	CD
cord-006229-7yoilsho	6516	39	]	]	-RRB-
cord-006229-7yoilsho	6516	40	may	may	MD
cord-006229-7yoilsho	6516	41	be	be	VB
cord-006229-7yoilsho	6516	42	linked	link	VBN
cord-006229-7yoilsho	6516	43	to	to	IN
cord-006229-7yoilsho	6516	44	loss	loss	NN
cord-006229-7yoilsho	6516	45	of	of	IN
cord-006229-7yoilsho	6516	46	histone	histone	NN
cord-006229-7yoilsho	6516	47	acetylation	acetylation	NN
cord-006229-7yoilsho	6516	48	.	.	.
cord-006229-7yoilsho	6517	1	In	in	IN
cord-006229-7yoilsho	6517	2	this	this	DT
cord-006229-7yoilsho	6517	3	study	study	NN
cord-006229-7yoilsho	6517	4	we	-PRON-	PRP
cord-006229-7yoilsho	6517	5	therefore	therefore	RB
cord-006229-7yoilsho	6517	6	used	use	VBD
cord-006229-7yoilsho	6517	7	a	a	DT
cord-006229-7yoilsho	6517	8	novel	novel	JJ
cord-006229-7yoilsho	6517	9	mass	mass	NN
cord-006229-7yoilsho	6517	10	spectrometry	spectrometry	NN
cord-006229-7yoilsho	6517	11	approach	approach	NN
cord-006229-7yoilsho	6517	12	,	,	,
cord-006229-7yoilsho	6517	13	which	which	WDT
cord-006229-7yoilsho	6517	14	is	be	VBZ
cord-006229-7yoilsho	6517	15	based	base	VBN
cord-006229-7yoilsho	6517	16	on	on	IN
cord-006229-7yoilsho	6517	17	chemical	chemical	JJ
cord-006229-7yoilsho	6517	18	acetylation	acetylation	NN
cord-006229-7yoilsho	6517	19	of	of	IN
cord-006229-7yoilsho	6517	20	unmodified	unmodified	JJ
cord-006229-7yoilsho	6517	21	lysine	lysine	NN
cord-006229-7yoilsho	6517	22	residues	residue	NNS
cord-006229-7yoilsho	6517	23	of	of	IN
cord-006229-7yoilsho	6517	24	histones	histone	NNS
cord-006229-7yoilsho	6517	25	using	use	VBG
cord-006229-7yoilsho	6517	26	13	13	CD
cord-006229-7yoilsho	6517	27	C	C	NNP
cord-006229-7yoilsho	6517	28	-	-	HYPH
cord-006229-7yoilsho	6517	29	labeled	label	VBN
cord-006229-7yoilsho	6517	30	acetic	acetic	NN
cord-006229-7yoilsho	6517	31	anhydride	anhydride	NN
cord-006229-7yoilsho	6517	32	and	and	CC
cord-006229-7yoilsho	6517	33	subsequent	subsequent	JJ
cord-006229-7yoilsho	6517	34	calculation	calculation	NN
cord-006229-7yoilsho	6517	35	of	of	IN
cord-006229-7yoilsho	6517	36	the	the	DT
cord-006229-7yoilsho	6517	37	degree	degree	NN
cord-006229-7yoilsho	6517	38	of	of	IN
cord-006229-7yoilsho	6517	39	acetylation	acetylation	NN
cord-006229-7yoilsho	6517	40	based	base	VBN
cord-006229-7yoilsho	6517	41	on	on	IN
cord-006229-7yoilsho	6517	42	the	the	DT
cord-006229-7yoilsho	6517	43	measured	measure	VBN
cord-006229-7yoilsho	6517	44	intensities	intensity	NNS
cord-006229-7yoilsho	6517	45	of	of	IN
cord-006229-7yoilsho	6517	46	heavy	heavy	JJ
cord-006229-7yoilsho	6517	47	and	and	CC
cord-006229-7yoilsho	6517	48	light	light	JJ
cord-006229-7yoilsho	6517	49	acetylated	acetylated	JJ
cord-006229-7yoilsho	6517	50	isotopologues	isotopologue	NNS
cord-006229-7yoilsho	6517	51	[	[	-LRB-
cord-006229-7yoilsho	6517	52	6	6	CD
cord-006229-7yoilsho	6517	53	]	]	-RRB-
cord-006229-7yoilsho	6517	54	,	,	,
cord-006229-7yoilsho	6517	55	to	to	TO
cord-006229-7yoilsho	6517	56	identify	identify	VB
cord-006229-7yoilsho	6517	57	and	and	CC
cord-006229-7yoilsho	6517	58	quantify	quantify	VB
cord-006229-7yoilsho	6517	59	site	site	NN
cord-006229-7yoilsho	6517	60	-	-	HYPH
cord-006229-7yoilsho	6517	61	specific	specific	JJ
cord-006229-7yoilsho	6517	62	alterations	alteration	NNS
cord-006229-7yoilsho	6517	63	in	in	IN
cord-006229-7yoilsho	6517	64	histone	histone	NN
cord-006229-7yoilsho	6517	65	acetylation	acetylation	NN
cord-006229-7yoilsho	6517	66	in	in	IN
cord-006229-7yoilsho	6517	67	human	human	JJ
cord-006229-7yoilsho	6517	68	kidney	kidney	NN
cord-006229-7yoilsho	6517	69	epithelial	epithelial	NN
cord-006229-7yoilsho	6517	70	(	(	-LRB-
cord-006229-7yoilsho	6517	71	HK-2	HK-2	NNP
cord-006229-7yoilsho	6517	72	)	)	-RRB-
cord-006229-7yoilsho	6517	73	cells	cell	NNS
cord-006229-7yoilsho	6517	74	treated	treat	VBN
cord-006229-7yoilsho	6517	75	with	with	IN
cord-006229-7yoilsho	6517	76	OTA	OTA	NNP
cord-006229-7yoilsho	6517	77	.	.	.
cord-006229-7yoilsho	6518	1	Our	-PRON-	PRP$
cord-006229-7yoilsho	6518	2	results	result	NNS
cord-006229-7yoilsho	6518	3	demonstrate	demonstrate	VBP
cord-006229-7yoilsho	6518	4	OTA	ota	NN
cord-006229-7yoilsho	6518	5	-	-	HYPH
cord-006229-7yoilsho	6518	6	mediated	mediate	VBN
cord-006229-7yoilsho	6518	7	loss	loss	NN
cord-006229-7yoilsho	6518	8	of	of	IN
cord-006229-7yoilsho	6518	9	acetylation	acetylation	NN
cord-006229-7yoilsho	6518	10	at	at	IN
cord-006229-7yoilsho	6518	11	almost	almost	RB
cord-006229-7yoilsho	6518	12	all	all	DT
cord-006229-7yoilsho	6518	13	important	important	JJ
cord-006229-7yoilsho	6518	14	lysine	lysine	NN
cord-006229-7yoilsho	6518	15	residues	residue	NNS
cord-006229-7yoilsho	6518	16	at	at	IN
cord-006229-7yoilsho	6518	17	histones	histone	NNS
cord-006229-7yoilsho	6518	18	H2A	h2a	WDT
cord-006229-7yoilsho	6518	19	,	,	,
cord-006229-7yoilsho	6518	20	H2B	H2B	NNP
cord-006229-7yoilsho	6518	21	,	,	,
cord-006229-7yoilsho	6518	22	H3	H3	NNP
cord-006229-7yoilsho	6518	23	and	and	CC
cord-006229-7yoilsho	6518	24	H4	H4	NNP
cord-006229-7yoilsho	6518	25	.	.	.
cord-006229-7yoilsho	6519	1	We	-PRON-	PRP
cord-006229-7yoilsho	6519	2	further	further	RB
cord-006229-7yoilsho	6519	3	selected	select	VBD
cord-006229-7yoilsho	6519	4	acetylation	acetylation	NN
cord-006229-7yoilsho	6519	5	at	at	IN
cord-006229-7yoilsho	6519	6	histone	histone	NN
cord-006229-7yoilsho	6519	7	H3	H3	NNP
cord-006229-7yoilsho	6519	8	lysine	lysine	NN
cord-006229-7yoilsho	6519	9	9	9	CD
cord-006229-7yoilsho	6519	10	(	(	-LRB-
cord-006229-7yoilsho	6519	11	H3K9	H3K9	NNP
cord-006229-7yoilsho	6519	12	)	)	-RRB-
cord-006229-7yoilsho	6519	13	,	,	,
cord-006229-7yoilsho	6519	14	a	a	DT
cord-006229-7yoilsho	6519	15	well	well	RB
cord-006229-7yoilsho	6519	16	-	-	HYPH
cord-006229-7yoilsho	6519	17	known	know	VBN
cord-006229-7yoilsho	6519	18	euchromatic	euchromatic	JJ
cord-006229-7yoilsho	6519	19	hallmark	hallmark	NN
cord-006229-7yoilsho	6519	20	that	that	WDT
cord-006229-7yoilsho	6519	21	is	be	VBZ
cord-006229-7yoilsho	6519	22	elevated	elevate	VBN
cord-006229-7yoilsho	6519	23	at	at	IN
cord-006229-7yoilsho	6519	24	promoter	promoter	NN
cord-006229-7yoilsho	6519	25	regions	region	NNS
cord-006229-7yoilsho	6519	26	of	of	IN
cord-006229-7yoilsho	6519	27	transcriptionally	transcriptionally	RB
cord-006229-7yoilsho	6519	28	active	active	JJ
cord-006229-7yoilsho	6519	29	genes	gene	NNS
cord-006229-7yoilsho	6519	30	[	[	-LRB-
cord-006229-7yoilsho	6519	31	7	7	CD
cord-006229-7yoilsho	6519	32	]	]	-RRB-
cord-006229-7yoilsho	6519	33	and	and	CC
cord-006229-7yoilsho	6519	34	which	which	WDT
cord-006229-7yoilsho	6519	35	was	be	VBD
cord-006229-7yoilsho	6519	36	reduced	reduce	VBN
cord-006229-7yoilsho	6519	37	from	from	IN
cord-006229-7yoilsho	6519	38	~	~	CD
cord-006229-7yoilsho	6519	39	3	3	CD
cord-006229-7yoilsho	6519	40	%	%	NN
cord-006229-7yoilsho	6519	41	in	in	IN
cord-006229-7yoilsho	6519	42	controls	control	NNS
cord-006229-7yoilsho	6519	43	to	to	IN
cord-006229-7yoilsho	6519	44	<	<	XX
cord-006229-7yoilsho	6519	45	0.1	0.1	CD
cord-006229-7yoilsho	6519	46	%	%	NN
cord-006229-7yoilsho	6519	47	in	in	IN
cord-006229-7yoilsho	6519	48	response	response	NN
cord-006229-7yoilsho	6519	49	to	to	IN
cord-006229-7yoilsho	6519	50	OTA	OTA	NNP
cord-006229-7yoilsho	6519	51	,	,	,
cord-006229-7yoilsho	6519	52	to	to	TO
cord-006229-7yoilsho	6519	53	establish	establish	VB
cord-006229-7yoilsho	6519	54	a	a	DT
cord-006229-7yoilsho	6519	55	link	link	NN
cord-006229-7yoilsho	6519	56	between	between	IN
cord-006229-7yoilsho	6519	57	loss	loss	NN
cord-006229-7yoilsho	6519	58	of	of	IN
cord-006229-7yoilsho	6519	59	H3K9	H3K9	NNP
cord-006229-7yoilsho	6519	60	acetylation	acetylation	NN
cord-006229-7yoilsho	6519	61	and	and	CC
cord-006229-7yoilsho	6519	62	expression	expression	NN
cord-006229-7yoilsho	6519	63	of	of	IN
cord-006229-7yoilsho	6519	64	genes	gene	NNS
cord-006229-7yoilsho	6519	65	consistently	consistently	RB
cord-006229-7yoilsho	6519	66	shown	show	VBN
cord-006229-7yoilsho	6519	67	to	to	TO
cord-006229-7yoilsho	6519	68	be	be	VB
cord-006229-7yoilsho	6519	69	down	down	RB
cord-006229-7yoilsho	6519	70	-	-	HYPH
cord-006229-7yoilsho	6519	71	regulated	regulate	VBN
cord-006229-7yoilsho	6519	72	in	in	IN
cord-006229-7yoilsho	6519	73	response	response	NN
cord-006229-7yoilsho	6519	74	to	to	IN
cord-006229-7yoilsho	6519	75	OTA	OTA	NNP
cord-006229-7yoilsho	6519	76	[	[	-LRB-
cord-006229-7yoilsho	6519	77	4	4	CD
cord-006229-7yoilsho	6519	78	,	,	,
cord-006229-7yoilsho	6519	79	5	5	CD
cord-006229-7yoilsho	6519	80	]	]	-RRB-
cord-006229-7yoilsho	6519	81	.	.	.
cord-006229-7yoilsho	6520	1	Using	use	VBG
cord-006229-7yoilsho	6520	2	chromatin	chromatin	NN
cord-006229-7yoilsho	6520	3	immunoprecipitation	immunoprecipitation	NN
cord-006229-7yoilsho	6520	4	followed	follow	VBN
cord-006229-7yoilsho	6520	5	by	by	IN
cord-006229-7yoilsho	6520	6	quantitative	quantitative	JJ
cord-006229-7yoilsho	6520	7	real	real	JJ
cord-006229-7yoilsho	6520	8	-	-	HYPH
cord-006229-7yoilsho	6520	9	time	time	NN
cord-006229-7yoilsho	6520	10	PCR	PCR	NNP
cord-006229-7yoilsho	6520	11	(	(	-LRB-
cord-006229-7yoilsho	6520	12	ChIP	chip	NN
cord-006229-7yoilsho	6520	13	-	-	HYPH
cord-006229-7yoilsho	6520	14	qPCR	qPCR	NNP
cord-006229-7yoilsho	6520	15	)	)	-RRB-
cord-006229-7yoilsho	6520	16	,	,	,
cord-006229-7yoilsho	6520	17	we	-PRON-	PRP
cord-006229-7yoilsho	6520	18	observed	observe	VBD
cord-006229-7yoilsho	6520	19	OTA	ota	NN
cord-006229-7yoilsho	6520	20	-	-	HYPH
cord-006229-7yoilsho	6520	21	mediated	mediate	VBN
cord-006229-7yoilsho	6520	22	loss	loss	NN
cord-006229-7yoilsho	6520	23	of	of	IN
cord-006229-7yoilsho	6520	24	H3K9	H3K9	NNP
cord-006229-7yoilsho	6520	25	acetylation	acetylation	NN
cord-006229-7yoilsho	6520	26	at	at	IN
cord-006229-7yoilsho	6520	27	promoter	promoter	NN
cord-006229-7yoilsho	6520	28	regions	region	NNS
cord-006229-7yoilsho	6520	29	of	of	IN
cord-006229-7yoilsho	6520	30	the	the	DT
cord-006229-7yoilsho	6520	31	selected	select	VBN
cord-006229-7yoilsho	6520	32	genes	gene	NNS
cord-006229-7yoilsho	6520	33	(	(	-LRB-
cord-006229-7yoilsho	6520	34	%	%	NN
cord-006229-7yoilsho	6520	35	of	of	IN
cord-006229-7yoilsho	6520	36	controls	control	NNS
cord-006229-7yoilsho	6520	37	:	:	:
cord-006229-7yoilsho	6521	1	AMIGO2	AMIGO2	NNP
cord-006229-7yoilsho	6521	2	:	:	:
cord-006229-7yoilsho	6521	3	45	45	CD
cord-006229-7yoilsho	6521	4	%	%	NN
cord-006229-7yoilsho	6521	5	,	,	,
cord-006229-7yoilsho	6521	6	CLASP2	CLASP2	NNPS
cord-006229-7yoilsho	6521	7	:	:	:
cord-006229-7yoilsho	6521	8	60	60	CD
cord-006229-7yoilsho	6521	9	%	%	NN
cord-006229-7yoilsho	6521	10	,	,	,
cord-006229-7yoilsho	6521	11	CTNND1	ctnnd1	NN
cord-006229-7yoilsho	6521	12	:	:	:
cord-006229-7yoilsho	6521	13	54	54	CD
cord-006229-7yoilsho	6521	14	%	%	NN
cord-006229-7yoilsho	6521	15	)	)	-RRB-
cord-006229-7yoilsho	6521	16	.	.	.
cord-006229-7yoilsho	6522	1	Overall	overall	RB
cord-006229-7yoilsho	6522	2	,	,	,
cord-006229-7yoilsho	6522	3	these	these	DT
cord-006229-7yoilsho	6522	4	data	datum	NNS
cord-006229-7yoilsho	6522	5	provide	provide	VBP
cord-006229-7yoilsho	6522	6	first	first	JJ
cord-006229-7yoilsho	6522	7	evidence	evidence	NN
cord-006229-7yoilsho	6522	8	for	for	IN
cord-006229-7yoilsho	6522	9	a	a	DT
cord-006229-7yoilsho	6522	10	mechanistic	mechanistic	JJ
cord-006229-7yoilsho	6522	11	link	link	NN
cord-006229-7yoilsho	6522	12	between	between	IN
cord-006229-7yoilsho	6522	13	H3K9	H3K9	NNP
cord-006229-7yoilsho	6522	14	hypoacetylation	hypoacetylation	NNP
cord-006229-7yoilsho	6522	15	as	as	IN
cord-006229-7yoilsho	6522	16	a	a	DT
cord-006229-7yoilsho	6522	17	consequence	consequence	NN
cord-006229-7yoilsho	6522	18	of	of	IN
cord-006229-7yoilsho	6522	19	OTA	ota	NN
cord-006229-7yoilsho	6522	20	-	-	HYPH
cord-006229-7yoilsho	6522	21	mediated	mediate	VBN
cord-006229-7yoilsho	6522	22	inhibition	inhibition	NN
cord-006229-7yoilsho	6522	23	of	of	IN
cord-006229-7yoilsho	6522	24	HATs	hat	NNS
cord-006229-7yoilsho	6522	25	and	and	CC
cord-006229-7yoilsho	6522	26	repression	repression	NN
cord-006229-7yoilsho	6522	27	of	of	IN
cord-006229-7yoilsho	6522	28	gene	gene	NN
cord-006229-7yoilsho	6522	29	expression	expression	NN
cord-006229-7yoilsho	6522	30	by	by	IN
cord-006229-7yoilsho	6522	31	OTA	OTA	NNP
cord-006229-7yoilsho	6522	32	.	.	.
cord-006229-7yoilsho	6523	1	A	a	DT
cord-006229-7yoilsho	6523	2	new	new	JJ
cord-006229-7yoilsho	6523	3	paradigm	paradigm	NN
cord-006229-7yoilsho	6523	4	to	to	TO
cord-006229-7yoilsho	6523	5	assess	assess	VB
cord-006229-7yoilsho	6523	6	the	the	DT
cord-006229-7yoilsho	6523	7	proarrhythmic	proarrhythmic	JJ
cord-006229-7yoilsho	6523	8	potential	potential	NN
cord-006229-7yoilsho	6523	9	of	of	IN
cord-006229-7yoilsho	6523	10	drugs	drug	NNS
cord-006229-7yoilsho	6523	11	is	be	VBZ
cord-006229-7yoilsho	6523	12	proposed	propose	VBN
cord-006229-7yoilsho	6523	13	by	by	IN
cord-006229-7yoilsho	6523	14	the	the	DT
cord-006229-7yoilsho	6523	15	CiPA	CiPA	NNP
cord-006229-7yoilsho	6523	16	(	(	-LRB-
cord-006229-7yoilsho	6523	17	Comprehensive	Comprehensive	NNP
cord-006229-7yoilsho	6523	18	in	in	IN
cord-006229-7yoilsho	6523	19	vitro	vitro	FW
cord-006229-7yoilsho	6523	20	Pro	pro	JJ
cord-006229-7yoilsho	6523	21	-	-	JJ
cord-006229-7yoilsho	6523	22	arrhythmia	arrhythmia	JJ
cord-006229-7yoilsho	6523	23	Assay	Assay	NNP
cord-006229-7yoilsho	6523	24	)	)	-RRB-
cord-006229-7yoilsho	6523	25	initiative	initiative	NN
cord-006229-7yoilsho	6523	26	combining	combine	VBG
cord-006229-7yoilsho	6523	27	a	a	DT
cord-006229-7yoilsho	6523	28	suite	suite	NN
cord-006229-7yoilsho	6523	29	of	of	IN
cord-006229-7yoilsho	6523	30	a	a	DT
cord-006229-7yoilsho	6523	31	priori	priori	FW
cord-006229-7yoilsho	6523	32	in	in	FW
cord-006229-7yoilsho	6523	33	vitro	vitro	FW
cord-006229-7yoilsho	6523	34	assays	assay	NNS
cord-006229-7yoilsho	6523	35	(	(	-LRB-
cord-006229-7yoilsho	6523	36	7	7	CD
cord-006229-7yoilsho	6523	37	most	most	RBS
cord-006229-7yoilsho	6523	38	important	important	JJ
cord-006229-7yoilsho	6523	39	ion	ion	NN
cord-006229-7yoilsho	6523	40	channels	channel	NNS
cord-006229-7yoilsho	6523	41	for	for	IN
cord-006229-7yoilsho	6523	42	cardiac	cardiac	JJ
cord-006229-7yoilsho	6523	43	activity	activity	NN
cord-006229-7yoilsho	6523	44	)	)	-RRB-
cord-006229-7yoilsho	6523	45	coupled	couple	VBN
cord-006229-7yoilsho	6523	46	to	to	IN
cord-006229-7yoilsho	6523	47	in	in	IN
cord-006229-7yoilsho	6523	48	silico	silico	NN
cord-006229-7yoilsho	6523	49	reconstructions	reconstruction	NNS
cord-006229-7yoilsho	6523	50	of	of	IN
cord-006229-7yoilsho	6523	51	cellular	cellular	JJ
cord-006229-7yoilsho	6523	52	cardiac	cardiac	JJ
cord-006229-7yoilsho	6523	53	action	action	NN
cord-006229-7yoilsho	6523	54	potential	potential	NN
cord-006229-7yoilsho	6523	55	(	(	-LRB-
cord-006229-7yoilsho	6523	56	AP	AP	NNP
cord-006229-7yoilsho	6523	57	)	)	-RRB-
cord-006229-7yoilsho	6523	58	.	.	.
cord-006229-7yoilsho	6524	1	The	the	DT
cord-006229-7yoilsho	6524	2	eTOX	etox	CD
cord-006229-7yoilsho	6524	3	consortium	consortium	NN
cord-006229-7yoilsho	6524	4	has	have	VBZ
cord-006229-7yoilsho	6524	5	developed	develop	VBN
cord-006229-7yoilsho	6524	6	a	a	DT
cord-006229-7yoilsho	6524	7	multiscale	multiscale	JJ
cord-006229-7yoilsho	6524	8	simulation	simulation	NN
cord-006229-7yoilsho	6524	9	in	in	IN
cord-006229-7yoilsho	6524	10	silico	silico	NN
cord-006229-7yoilsho	6524	11	model	model	NN
cord-006229-7yoilsho	6524	12	based	base	VBN
cord-006229-7yoilsho	6524	13	on	on	IN
cord-006229-7yoilsho	6524	14	O'Hara	O'Hara	NNP
cord-006229-7yoilsho	6524	15	/	/	SYM
cord-006229-7yoilsho	6524	16	Rudy	Rudy	NNP
cord-006229-7yoilsho	6524	17	incorporating	incorporate	VBG
cord-006229-7yoilsho	6524	18	the	the	DT
cord-006229-7yoilsho	6524	19	principles	principle	NNS
cord-006229-7yoilsho	6524	20	of	of	IN
cord-006229-7yoilsho	6524	21	this	this	DT
cord-006229-7yoilsho	6524	22	new	new	JJ
cord-006229-7yoilsho	6524	23	paradigm	paradigm	NN
cord-006229-7yoilsho	6524	24	.	.	.
cord-006229-7yoilsho	6525	1	The	the	DT
cord-006229-7yoilsho	6525	2	core	core	NN
cord-006229-7yoilsho	6525	3	model	model	NN
cord-006229-7yoilsho	6525	4	simulates	simulate	VBZ
cord-006229-7yoilsho	6525	5	the	the	DT
cord-006229-7yoilsho	6525	6	effects	effect	NNS
cord-006229-7yoilsho	6525	7	of	of	IN
cord-006229-7yoilsho	6525	8	drugs	drug	NNS
cord-006229-7yoilsho	6525	9	on	on	IN
cord-006229-7yoilsho	6525	10	a	a	DT
cord-006229-7yoilsho	6525	11	virtual	virtual	JJ
cord-006229-7yoilsho	6525	12	cardiac	cardiac	JJ
cord-006229-7yoilsho	6525	13	tissue	tissue	NN
cord-006229-7yoilsho	6525	14	composed	compose	VBN
cord-006229-7yoilsho	6525	15	by	by	IN
cord-006229-7yoilsho	6525	16	different	different	JJ
cord-006229-7yoilsho	6525	17	types	type	NNS
cord-006229-7yoilsho	6525	18	of	of	IN
cord-006229-7yoilsho	6525	19	cardiomyocytes	cardiomyocyte	NNS
cord-006229-7yoilsho	6525	20	.	.	.
cord-006229-7yoilsho	6526	1	The	the	DT
cord-006229-7yoilsho	6526	2	input	input	NN
cord-006229-7yoilsho	6526	3	of	of	IN
cord-006229-7yoilsho	6526	4	this	this	DT
cord-006229-7yoilsho	6526	5	model	model	NN
cord-006229-7yoilsho	6526	6	,	,	,
cord-006229-7yoilsho	6526	7	the	the	DT
cord-006229-7yoilsho	6526	8	blockade	blockade	NN
cord-006229-7yoilsho	6526	9	of	of	IN
cord-006229-7yoilsho	6526	10	a	a	DT
cord-006229-7yoilsho	6526	11	set	set	NN
cord-006229-7yoilsho	6526	12	of	of	IN
cord-006229-7yoilsho	6526	13	3	3	CD
cord-006229-7yoilsho	6526	14	ion	ion	NN
cord-006229-7yoilsho	6526	15	channels	channel	NNS
cord-006229-7yoilsho	6526	16	(	(	-LRB-
cord-006229-7yoilsho	6526	17	IKr	IKr	NNP
cord-006229-7yoilsho	6526	18	/	/	SYM
cord-006229-7yoilsho	6526	19	hERG	herg	XX
cord-006229-7yoilsho	6526	20	,	,	,
cord-006229-7yoilsho	6526	21	IKs	IKs	NNP
cord-006229-7yoilsho	6526	22	,	,	,
cord-006229-7yoilsho	6526	23	ICaL	ICaL	NNP
cord-006229-7yoilsho	6526	24	)	)	-RRB-
cord-006229-7yoilsho	6526	25	,	,	,
cord-006229-7yoilsho	6526	26	can	can	MD
cord-006229-7yoilsho	6526	27	be	be	VB
cord-006229-7yoilsho	6526	28	obtained	obtain	VBN
cord-006229-7yoilsho	6526	29	experimentally	experimentally	RB
cord-006229-7yoilsho	6526	30	or	or	CC
cord-006229-7yoilsho	6526	31	predicted	predict	VBN
cord-006229-7yoilsho	6526	32	using	use	VBG
cord-006229-7yoilsho	6526	33	advanced	advanced	JJ
cord-006229-7yoilsho	6526	34	3D	3d	JJ
cord-006229-7yoilsho	6526	35	-	-	HYPH
cord-006229-7yoilsho	6526	36	QSAR	QSAR	NNP
cord-006229-7yoilsho	6526	37	models	model	NNS
cord-006229-7yoilsho	6526	38	.	.	.
cord-006229-7yoilsho	6527	1	The	the	DT
cord-006229-7yoilsho	6527	2	system	system	NN
cord-006229-7yoilsho	6527	3	predicts	predict	VBZ
cord-006229-7yoilsho	6527	4	the	the	DT
cord-006229-7yoilsho	6527	5	%	%	NN
cord-006229-7yoilsho	6527	6	change	change	NN
cord-006229-7yoilsho	6527	7	of	of	IN
cord-006229-7yoilsho	6527	8	the	the	DT
cord-006229-7yoilsho	6527	9	QT	QT	NNP
cord-006229-7yoilsho	6527	10	interval	interval	NN
cord-006229-7yoilsho	6527	11	at	at	IN
cord-006229-7yoilsho	6527	12	different	different	JJ
cord-006229-7yoilsho	6527	13	drug	drug	NN
cord-006229-7yoilsho	6527	14	concentrations	concentration	NNS
cord-006229-7yoilsho	6527	15	in	in	IN
cord-006229-7yoilsho	6527	16	order	order	NN
cord-006229-7yoilsho	6527	17	to	to	TO
cord-006229-7yoilsho	6527	18	facilitate	facilitate	VB
cord-006229-7yoilsho	6527	19	risk	risk	NN
cord-006229-7yoilsho	6527	20	assessment	assessment	NN
cord-006229-7yoilsho	6527	21	.	.	.
cord-006229-7yoilsho	6528	1	This	this	DT
cord-006229-7yoilsho	6528	2	in	in	IN
cord-006229-7yoilsho	6528	3	silico	silico	NN
cord-006229-7yoilsho	6528	4	model	model	NN
cord-006229-7yoilsho	6528	5	was	be	VBD
cord-006229-7yoilsho	6528	6	validated	validate	VBN
cord-006229-7yoilsho	6528	7	using	use	VBG
cord-006229-7yoilsho	6528	8	Purkinje	Purkinje	NNP
cord-006229-7yoilsho	6528	9	fiber	fiber	NN
cord-006229-7yoilsho	6528	10	assay	assay	NN
cord-006229-7yoilsho	6528	11	results	result	NNS
cord-006229-7yoilsho	6528	12	(	(	-LRB-
cord-006229-7yoilsho	6528	13	input	input	NN
cord-006229-7yoilsho	6528	14	:	:	:
cord-006229-7yoilsho	6528	15	AP	AP	NNP
cord-006229-7yoilsho	6528	16	prolongation	prolongation	NN
cord-006229-7yoilsho	6528	17	and	and	CC
cord-006229-7yoilsho	6528	18	arrhythmogenic	arrhythmogenic	JJ
cord-006229-7yoilsho	6528	19	risk	risk	NN
cord-006229-7yoilsho	6528	20	assessed	assess	VBN
cord-006229-7yoilsho	6528	21	by	by	IN
cord-006229-7yoilsho	6528	22	early	early	RB
cord-006229-7yoilsho	6528	23	after	after	NN
cord-006229-7yoilsho	6528	24	-	-	HYPH
cord-006229-7yoilsho	6528	25	depolarisation	depolarisation	NN
cord-006229-7yoilsho	6528	26	occurrence	occurrence	NN
cord-006229-7yoilsho	6528	27	)	)	-RRB-
cord-006229-7yoilsho	6528	28	from	from	IN
cord-006229-7yoilsho	6528	29	500	500	CD
cord-006229-7yoilsho	6528	30	in	in	IN
cord-006229-7yoilsho	6528	31	-	-	HYPH
cord-006229-7yoilsho	6528	32	house	house	NN
cord-006229-7yoilsho	6528	33	drug	drug	NN
cord-006229-7yoilsho	6528	34	candidates	candidate	NNS
cord-006229-7yoilsho	6528	35	.	.	.
cord-006229-7yoilsho	6529	1	The	the	DT
cord-006229-7yoilsho	6529	2	validation	validation	NN
cord-006229-7yoilsho	6529	3	showed	show	VBD
cord-006229-7yoilsho	6529	4	that	that	IN
cord-006229-7yoilsho	6529	5	predictivity	predictivity	NN
cord-006229-7yoilsho	6529	6	is	be	VBZ
cord-006229-7yoilsho	6529	7	highly	highly	RB
cord-006229-7yoilsho	6529	8	dependent	dependent	JJ
cord-006229-7yoilsho	6529	9	on	on	IN
cord-006229-7yoilsho	6529	10	the	the	DT
cord-006229-7yoilsho	6529	11	model	model	NN
cord-006229-7yoilsho	6529	12	's	's	POS
cord-006229-7yoilsho	6529	13	applicability	applicability	NN
cord-006229-7yoilsho	6529	14	domain	domain	NN
cord-006229-7yoilsho	6529	15	(	(	-LRB-
cord-006229-7yoilsho	6529	16	AD	ad	NN
cord-006229-7yoilsho	6529	17	)	)	-RRB-
cord-006229-7yoilsho	6529	18	:	:	:
cord-006229-7yoilsho	6529	19	for	for	IN
cord-006229-7yoilsho	6529	20	some	some	DT
cord-006229-7yoilsho	6529	21	chemical	chemical	NN
cord-006229-7yoilsho	6529	22	series	series	NN
cord-006229-7yoilsho	6529	23	the	the	DT
cord-006229-7yoilsho	6529	24	proarrhythmic	proarrhythmic	JJ
cord-006229-7yoilsho	6529	25	potential	potential	NN
cord-006229-7yoilsho	6529	26	could	could	MD
cord-006229-7yoilsho	6529	27	not	not	RB
cord-006229-7yoilsho	6529	28	be	be	VB
cord-006229-7yoilsho	6529	29	identified	identify	VBN
cord-006229-7yoilsho	6529	30	,	,	,
cord-006229-7yoilsho	6529	31	for	for	IN
cord-006229-7yoilsho	6529	32	others	other	NNS
cord-006229-7yoilsho	6529	33	,	,	,
cord-006229-7yoilsho	6529	34	however	however	RB
cord-006229-7yoilsho	6529	35	,	,	,
cord-006229-7yoilsho	6529	36	most	most	JJS
cord-006229-7yoilsho	6529	37	of	of	IN
cord-006229-7yoilsho	6529	38	the	the	DT
cord-006229-7yoilsho	6529	39	positive	positive	JJ
cord-006229-7yoilsho	6529	40	drugs	drug	NNS
cord-006229-7yoilsho	6529	41	were	be	VBD
cord-006229-7yoilsho	6529	42	correctly	correctly	RB
cord-006229-7yoilsho	6529	43	predicted	predict	VBN
cord-006229-7yoilsho	6529	44	with	with	IN
cord-006229-7yoilsho	6529	45	sensitivities	sensitivity	NNS
cord-006229-7yoilsho	6529	46	up	up	IN
cord-006229-7yoilsho	6529	47	to	to	TO
cord-006229-7yoilsho	6529	48	80	80	CD
cord-006229-7yoilsho	6529	49	-	-	SYM
cord-006229-7yoilsho	6529	50	90	90	CD
cord-006229-7yoilsho	6529	51	%	%	NN
cord-006229-7yoilsho	6529	52	(	(	-LRB-
cord-006229-7yoilsho	6529	53	average	average	JJ
cord-006229-7yoilsho	6529	54	prediction	prediction	NN
cord-006229-7yoilsho	6529	55	accuracy	accuracy	NN
cord-006229-7yoilsho	6529	56	was	be	VBD
cord-006229-7yoilsho	6529	57	70	70	CD
cord-006229-7yoilsho	6529	58	%	%	NN
cord-006229-7yoilsho	6529	59	)	)	-RRB-
cord-006229-7yoilsho	6529	60	.	.	.
cord-006229-7yoilsho	6530	1	Retraining	retrain	VBG
cord-006229-7yoilsho	6530	2	of	of	IN
cord-006229-7yoilsho	6530	3	this	this	DT
cord-006229-7yoilsho	6530	4	model	model	NN
cord-006229-7yoilsho	6530	5	with	with	IN
cord-006229-7yoilsho	6530	6	additional	additional	JJ
cord-006229-7yoilsho	6530	7	internal	internal	JJ
cord-006229-7yoilsho	6530	8	data	datum	NNS
cord-006229-7yoilsho	6530	9	should	should	MD
cord-006229-7yoilsho	6530	10	help	help	VB
cord-006229-7yoilsho	6530	11	to	to	TO
cord-006229-7yoilsho	6530	12	improve	improve	VB
cord-006229-7yoilsho	6530	13	the	the	DT
cord-006229-7yoilsho	6530	14	model	model	NN
cord-006229-7yoilsho	6530	15	AD	ad	NN
cord-006229-7yoilsho	6530	16	and	and	CC
cord-006229-7yoilsho	6530	17	predictivity	predictivity	NN
cord-006229-7yoilsho	6530	18	.	.	.
cord-006229-7yoilsho	6531	1	It	-PRON-	PRP
cord-006229-7yoilsho	6531	2	is	be	VBZ
cord-006229-7yoilsho	6531	3	important	important	JJ
cord-006229-7yoilsho	6531	4	to	to	TO
cord-006229-7yoilsho	6531	5	note	note	VB
cord-006229-7yoilsho	6531	6	that	that	IN
cord-006229-7yoilsho	6531	7	AP	AP	NNP
cord-006229-7yoilsho	6531	8	prolongation	prolongation	NN
cord-006229-7yoilsho	6531	9	was	be	VBD
cord-006229-7yoilsho	6531	10	correctly	correctly	RB
cord-006229-7yoilsho	6531	11	predicted	predict	VBN
cord-006229-7yoilsho	6531	12	for	for	IN
cord-006229-7yoilsho	6531	13	many	many	JJ
cord-006229-7yoilsho	6531	14	proarrhythmic	proarrhythmic	JJ
cord-006229-7yoilsho	6531	15	drugs	drug	NNS
cord-006229-7yoilsho	6531	16	with	with	IN
cord-006229-7yoilsho	6531	17	only	only	RB
cord-006229-7yoilsho	6531	18	low	low	JJ
cord-006229-7yoilsho	6531	19	(	(	-LRB-
cord-006229-7yoilsho	6531	20	>	>	NFP
cord-006229-7yoilsho	6531	21	30	30	CD
cord-006229-7yoilsho	6531	22	µM	µm	CD
cord-006229-7yoilsho	6531	23	)	)	-RRB-
cord-006229-7yoilsho	6531	24	in	in	IN
cord-006229-7yoilsho	6531	25	vitro	vitro	FW
cord-006229-7yoilsho	6531	26	hERG	herg	NN
cord-006229-7yoilsho	6531	27	inhibition	inhibition	NN
cord-006229-7yoilsho	6531	28	.	.	.
cord-006229-7yoilsho	6532	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	6532	2	,	,	,
cord-006229-7yoilsho	6532	3	the	the	DT
cord-006229-7yoilsho	6532	4	model	model	NN
cord-006229-7yoilsho	6532	5	showed	show	VBD
cord-006229-7yoilsho	6532	6	high	high	JJ
cord-006229-7yoilsho	6532	7	additional	additional	JJ
cord-006229-7yoilsho	6532	8	benefit	benefit	NN
cord-006229-7yoilsho	6532	9	for	for	IN
cord-006229-7yoilsho	6532	10	read	read	NN
cord-006229-7yoilsho	6532	11	-	-	HYPH
cord-006229-7yoilsho	6532	12	across	across	NN
cord-006229-7yoilsho	6532	13	within	within	IN
cord-006229-7yoilsho	6532	14	Bayer	Bayer	NNP
cord-006229-7yoilsho	6532	15	Pharma	Pharma	NNP
cord-006229-7yoilsho	6532	16	AG	AG	NNP
cord-006229-7yoilsho	6532	17	,	,	,
cord-006229-7yoilsho	6532	18	Investigational	Investigational	NNP
cord-006229-7yoilsho	6532	19	Toxicology	Toxicology	NNP
cord-006229-7yoilsho	6532	20	,	,	,
cord-006229-7yoilsho	6532	21	Berlin	Berlin	NNP
cord-006229-7yoilsho	6532	22	,	,	,
cord-006229-7yoilsho	6532	23	Germany	Germany	NNP
cord-006229-7yoilsho	6532	24	eTOX	etox	CD
cord-006229-7yoilsho	6533	1	[	[	-LRB-
cord-006229-7yoilsho	6533	2	1	1	CD
cord-006229-7yoilsho	6533	3	]	]	-RRB-
cord-006229-7yoilsho	6533	4	[	[	-LRB-
cord-006229-7yoilsho	6533	5	2	2	CD
cord-006229-7yoilsho	6533	6	]	]	-RRB-
cord-006229-7yoilsho	6533	7	started	start	VBN
cord-006229-7yoilsho	6533	8	in	in	IN
cord-006229-7yoilsho	6533	9	2010	2010	CD
cord-006229-7yoilsho	6533	10	and	and	CC
cord-006229-7yoilsho	6533	11	is	be	VBZ
cord-006229-7yoilsho	6533	12	a	a	DT
cord-006229-7yoilsho	6533	13	public	public	JJ
cord-006229-7yoilsho	6533	14	-	-	HYPH
cord-006229-7yoilsho	6533	15	private	private	JJ
cord-006229-7yoilsho	6533	16	partnership	partnership	NN
cord-006229-7yoilsho	6533	17	project	project	NN
cord-006229-7yoilsho	6533	18	within	within	IN
cord-006229-7yoilsho	6533	19	the	the	DT
cord-006229-7yoilsho	6533	20	European	European	NNP
cord-006229-7yoilsho	6533	21	Innovative	Innovative	NNP
cord-006229-7yoilsho	6533	22	Medicines	Medicines	NNPS
cord-006229-7yoilsho	6533	23	Initiative	Initiative	NNP
cord-006229-7yoilsho	6533	24	(	(	-LRB-
cord-006229-7yoilsho	6533	25	IMI	IMI	NNP
cord-006229-7yoilsho	6533	26	)	)	-RRB-
cord-006229-7yoilsho	6534	1	[	[	-LRB-
cord-006229-7yoilsho	6534	2	3	3	CD
cord-006229-7yoilsho	6534	3	]	]	-RRB-
cord-006229-7yoilsho	6534	4	.	.	.
cord-006229-7yoilsho	6535	1	The	the	DT
cord-006229-7yoilsho	6535	2	eTOX	etox	CD
cord-006229-7yoilsho	6535	3	project	project	NN
cord-006229-7yoilsho	6535	4	is	be	VBZ
cord-006229-7yoilsho	6535	5	building	build	VBG
cord-006229-7yoilsho	6535	6	a	a	DT
cord-006229-7yoilsho	6535	7	toxicology	toxicology	NN
cord-006229-7yoilsho	6535	8	database	database	NN
cord-006229-7yoilsho	6535	9	relevant	relevant	JJ
cord-006229-7yoilsho	6535	10	to	to	IN
cord-006229-7yoilsho	6535	11	pharmaceutical	pharmaceutical	JJ
cord-006229-7yoilsho	6535	12	development	development	NN
cord-006229-7yoilsho	6535	13	and	and	CC
cord-006229-7yoilsho	6535	14	to	to	TO
cord-006229-7yoilsho	6535	15	elaborate	elaborate	VB
cord-006229-7yoilsho	6535	16	innovative	innovative	JJ
cord-006229-7yoilsho	6535	17	strategies	strategy	NNS
cord-006229-7yoilsho	6535	18	and	and	CC
cord-006229-7yoilsho	6535	19	software	software	NN
cord-006229-7yoilsho	6535	20	tools	tool	NNS
cord-006229-7yoilsho	6535	21	.	.	.
cord-006229-7yoilsho	6536	1	The	the	DT
cord-006229-7yoilsho	6536	2	overall	overall	JJ
cord-006229-7yoilsho	6536	3	goal	goal	NN
cord-006229-7yoilsho	6536	4	is	be	VBZ
cord-006229-7yoilsho	6536	5	to	to	TO
cord-006229-7yoilsho	6536	6	better	better	RB
cord-006229-7yoilsho	6536	7	predict	predict	VB
cord-006229-7yoilsho	6536	8	the	the	DT
cord-006229-7yoilsho	6536	9	toxicological	toxicological	JJ
cord-006229-7yoilsho	6536	10	profiles	profile	NNS
cord-006229-7yoilsho	6536	11	of	of	IN
cord-006229-7yoilsho	6536	12	new	new	JJ
cord-006229-7yoilsho	6536	13	chemical	chemical	JJ
cord-006229-7yoilsho	6536	14	entities	entity	NNS
cord-006229-7yoilsho	6536	15	in	in	IN
cord-006229-7yoilsho	6536	16	early	early	JJ
cord-006229-7yoilsho	6536	17	stages	stage	NNS
cord-006229-7yoilsho	6536	18	of	of	IN
cord-006229-7yoilsho	6536	19	the	the	DT
cord-006229-7yoilsho	6536	20	drug	drug	NN
cord-006229-7yoilsho	6536	21	development	development	NN
cord-006229-7yoilsho	6536	22	pipeline	pipeline	NN
cord-006229-7yoilsho	6536	23	based	base	VBN
cord-006229-7yoilsho	6536	24	on	on	IN
cord-006229-7yoilsho	6536	25	existing	exist	VBG
cord-006229-7yoilsho	6536	26	in	in	IN
cord-006229-7yoilsho	6536	27	vivo	vivo	NN
cord-006229-7yoilsho	6536	28	study	study	NN
cord-006229-7yoilsho	6536	29	results	result	NNS
cord-006229-7yoilsho	6536	30	contributed	contribute	VBN
cord-006229-7yoilsho	6536	31	by	by	IN
cord-006229-7yoilsho	6536	32	the	the	DT
cord-006229-7yoilsho	6536	33	participating	participate	VBG
cord-006229-7yoilsho	6536	34	EFPIA	EFPIA	NNP
cord-006229-7yoilsho	6536	35	*	*	NFP
cord-006229-7yoilsho	6536	36	companies	company	NNS
cord-006229-7yoilsho	6536	37	in	in	IN
cord-006229-7yoilsho	6536	38	the	the	DT
cord-006229-7yoilsho	6536	39	consortium	consortium	NN
cord-006229-7yoilsho	6536	40	.	.	.
cord-006229-7yoilsho	6537	1	The	the	DT
cord-006229-7yoilsho	6537	2	eTOX	etox	CD
cord-006229-7yoilsho	6537	3	database	database	NN
cord-006229-7yoilsho	6537	4	is	be	VBZ
cord-006229-7yoilsho	6537	5	a	a	DT
cord-006229-7yoilsho	6537	6	relational	relational	JJ
cord-006229-7yoilsho	6537	7	database	database	NN
cord-006229-7yoilsho	6537	8	with	with	IN
cord-006229-7yoilsho	6537	9	a	a	DT
cord-006229-7yoilsho	6537	10	specifically	specifically	RB
cord-006229-7yoilsho	6537	11	designed	design	VBN
cord-006229-7yoilsho	6537	12	schema	schema	NN
cord-006229-7yoilsho	6537	13	to	to	TO
cord-006229-7yoilsho	6537	14	store	store	VB
cord-006229-7yoilsho	6537	15	complex	complex	JJ
cord-006229-7yoilsho	6537	16	and	and	CC
cord-006229-7yoilsho	6537	17	comprehensive	comprehensive	JJ
cord-006229-7yoilsho	6537	18	preclinical	preclinical	JJ
cord-006229-7yoilsho	6537	19	safety	safety	NN
cord-006229-7yoilsho	6537	20	data	datum	NNS
cord-006229-7yoilsho	6537	21	like	like	IN
cord-006229-7yoilsho	6537	22	the	the	DT
cord-006229-7yoilsho	6537	23	study	study	NN
cord-006229-7yoilsho	6537	24	design	design	NN
cord-006229-7yoilsho	6537	25	,	,	,
cord-006229-7yoilsho	6537	26	toxicokinetics	toxicokinetic	NNS
cord-006229-7yoilsho	6537	27	,	,	,
cord-006229-7yoilsho	6537	28	ADME	ADME	NNP
cord-006229-7yoilsho	6537	29	data	datum	NNS
cord-006229-7yoilsho	6537	30	,	,	,
cord-006229-7yoilsho	6537	31	clinical	clinical	JJ
cord-006229-7yoilsho	6537	32	chemistry	chemistry	NN
cord-006229-7yoilsho	6537	33	,	,	,
cord-006229-7yoilsho	6537	34	hematology	hematology	NN
cord-006229-7yoilsho	6537	35	,	,	,
cord-006229-7yoilsho	6537	36	gross	gross	JJ
cord-006229-7yoilsho	6537	37	necropsy	necropsy	JJ
cord-006229-7yoilsho	6537	38	,	,	,
cord-006229-7yoilsho	6537	39	histopathological	histopathological	JJ
cord-006229-7yoilsho	6537	40	findings	finding	NNS
cord-006229-7yoilsho	6537	41	and	and	CC
cord-006229-7yoilsho	6537	42	general	general	JJ
cord-006229-7yoilsho	6537	43	toxic	toxic	JJ
cord-006229-7yoilsho	6537	44	effects	effect	NNS
cord-006229-7yoilsho	6537	45	.	.	.
cord-006229-7yoilsho	6538	1	In	in	IN
cord-006229-7yoilsho	6538	2	addition	addition	NN
cord-006229-7yoilsho	6538	3	relevant	relevant	JJ
cord-006229-7yoilsho	6538	4	data	datum	NNS
cord-006229-7yoilsho	6538	5	from	from	IN
cord-006229-7yoilsho	6538	6	public	public	JJ
cord-006229-7yoilsho	6538	7	sources	source	NNS
cord-006229-7yoilsho	6538	8	has	have	VBZ
cord-006229-7yoilsho	6538	9	been	be	VBN
cord-006229-7yoilsho	6538	10	included	include	VBN
cord-006229-7yoilsho	6538	11	into	into	IN
cord-006229-7yoilsho	6538	12	the	the	DT
cord-006229-7yoilsho	6538	13	database	database	NN
cord-006229-7yoilsho	6538	14	.	.	.
cord-006229-7yoilsho	6539	1	The	the	DT
cord-006229-7yoilsho	6539	2	primary	primary	JJ
cord-006229-7yoilsho	6539	3	focus	focus	NN
cord-006229-7yoilsho	6539	4	for	for	IN
cord-006229-7yoilsho	6539	5	data	datum	NNS
cord-006229-7yoilsho	6539	6	collection	collection	NN
cord-006229-7yoilsho	6539	7	are	be	VBP
cord-006229-7yoilsho	6539	8	systemic	systemic	JJ
cord-006229-7yoilsho	6539	9	toxicity	toxicity	NN
cord-006229-7yoilsho	6539	10	(	(	-LRB-
cord-006229-7yoilsho	6539	11	up	up	IN
cord-006229-7yoilsho	6539	12	to	to	TO
cord-006229-7yoilsho	6539	13	4	4	CD
cord-006229-7yoilsho	6539	14	week	week	NN
cord-006229-7yoilsho	6539	15	)	)	-RRB-
cord-006229-7yoilsho	6539	16	repeated	repeat	VBD
cord-006229-7yoilsho	6539	17	dose	dose	JJ
cord-006229-7yoilsho	6539	18	studies	study	NNS
cord-006229-7yoilsho	6539	19	,	,	,
cord-006229-7yoilsho	6539	20	mostly	mostly	RB
cord-006229-7yoilsho	6539	21	in	in	IN
cord-006229-7yoilsho	6539	22	rodent	rodent	NN
cord-006229-7yoilsho	6539	23	.	.	.
cord-006229-7yoilsho	6540	1	Overall	overall	RB
cord-006229-7yoilsho	6540	2	more	more	JJR
cord-006229-7yoilsho	6540	3	than	than	IN
cord-006229-7yoilsho	6540	4	7000	7000	CD
cord-006229-7yoilsho	6540	5	study	study	NN
cord-006229-7yoilsho	6540	6	reports	report	NNS
cord-006229-7yoilsho	6540	7	for	for	IN
cord-006229-7yoilsho	6540	8	approximately	approximately	RB
cord-006229-7yoilsho	6540	9	1400	1400	CD
cord-006229-7yoilsho	6540	10	investigated	investigate	VBN
cord-006229-7yoilsho	6540	11	compounds	compound	NNS
cord-006229-7yoilsho	6540	12	.	.	.
cord-006229-7yoilsho	6541	1	In	in	IN
cord-006229-7yoilsho	6541	2	order	order	NN
cord-006229-7yoilsho	6541	3	to	to	TO
cord-006229-7yoilsho	6541	4	optimize	optimize	VB
cord-006229-7yoilsho	6541	5	the	the	DT
cord-006229-7yoilsho	6541	6	usage	usage	NN
cord-006229-7yoilsho	6541	7	and	and	CC
cord-006229-7yoilsho	6541	8	mapping	mapping	NN
cord-006229-7yoilsho	6541	9	of	of	IN
cord-006229-7yoilsho	6541	10	data	datum	NNS
cord-006229-7yoilsho	6541	11	from	from	IN
cord-006229-7yoilsho	6541	12	different	different	JJ
cord-006229-7yoilsho	6541	13	sources	source	NNS
cord-006229-7yoilsho	6541	14	the	the	DT
cord-006229-7yoilsho	6541	15	development	development	NN
cord-006229-7yoilsho	6541	16	of	of	IN
cord-006229-7yoilsho	6541	17	common	common	JJ
cord-006229-7yoilsho	6541	18	ontologies	ontology	NNS
cord-006229-7yoilsho	6541	19	was	be	VBD
cord-006229-7yoilsho	6541	20	a	a	DT
cord-006229-7yoilsho	6541	21	key	key	JJ
cord-006229-7yoilsho	6541	22	task	task	NN
cord-006229-7yoilsho	6541	23	within	within	IN
cord-006229-7yoilsho	6541	24	the	the	DT
cord-006229-7yoilsho	6541	25	project	project	NN
cord-006229-7yoilsho	6541	26	.	.	.
cord-006229-7yoilsho	6542	1	This	this	DT
cord-006229-7yoilsho	6542	2	timeconsuming	timeconsuming	JJ
cord-006229-7yoilsho	6542	3	step	step	NN
cord-006229-7yoilsho	6542	4	was	be	VBD
cord-006229-7yoilsho	6542	5	necessary	necessary	JJ
cord-006229-7yoilsho	6542	6	to	to	TO
cord-006229-7yoilsho	6542	7	make	make	VB
cord-006229-7yoilsho	6542	8	a	a	DT
cord-006229-7yoilsho	6542	9	high	high	JJ
cord-006229-7yoilsho	6542	10	quality	quality	NN
cord-006229-7yoilsho	6542	11	read	read	NN
cord-006229-7yoilsho	6542	12	-	-	HYPH
cord-006229-7yoilsho	6542	13	across	across	RP
cord-006229-7yoilsho	6542	14	analysis	analysis	NN
cord-006229-7yoilsho	6542	15	possible	possible	JJ
cord-006229-7yoilsho	6542	16	and	and	CC
cord-006229-7yoilsho	6542	17	valuable	valuable	JJ
cord-006229-7yoilsho	6542	18	.	.	.
cord-006229-7yoilsho	6543	1	Therefore	therefore	RB
cord-006229-7yoilsho	6543	2	the	the	DT
cord-006229-7yoilsho	6543	3	OntoBrowser	OntoBrowser	NNP
cord-006229-7yoilsho	6543	4	[	[	-LRB-
cord-006229-7yoilsho	6543	5	4	4	CD
cord-006229-7yoilsho	6543	6	]	]	-RRB-
cord-006229-7yoilsho	6543	7	tool	tool	NN
cord-006229-7yoilsho	6543	8	was	be	VBD
cord-006229-7yoilsho	6543	9	developed	develop	VBN
cord-006229-7yoilsho	6543	10	to	to	TO
cord-006229-7yoilsho	6543	11	curate	curate	VB
cord-006229-7yoilsho	6543	12	and	and	CC
cord-006229-7yoilsho	6543	13	harmonize	harmonize	VB
cord-006229-7yoilsho	6543	14	the	the	DT
cord-006229-7yoilsho	6543	15	verbatim	verbatim	JJ
cord-006229-7yoilsho	6543	16	terms	term	NNS
cord-006229-7yoilsho	6543	17	to	to	TO
cord-006229-7yoilsho	6543	18	standardize	standardize	VB
cord-006229-7yoilsho	6543	19	terms	term	NNS
cord-006229-7yoilsho	6543	20	which	which	WDT
cord-006229-7yoilsho	6543	21	are	be	VBP
cord-006229-7yoilsho	6543	22	used	use	VBN
cord-006229-7yoilsho	6543	23	within	within	IN
cord-006229-7yoilsho	6543	24	the	the	DT
cord-006229-7yoilsho	6543	25	eTOX	etox	CD
cord-006229-7yoilsho	6543	26	database	database	NN
cord-006229-7yoilsho	6543	27	.	.	.
cord-006229-7yoilsho	6544	1	Until	until	IN
cord-006229-7yoilsho	6544	2	now	now	RB
cord-006229-7yoilsho	6544	3	more	more	JJR
cord-006229-7yoilsho	6544	4	than	than	IN
cord-006229-7yoilsho	6544	5	13	13	CD
cord-006229-7yoilsho	6544	6	million	million	CD
cord-006229-7yoilsho	6544	7	verbatim	verbatim	JJ
cord-006229-7yoilsho	6544	8	terms	term	NNS
cord-006229-7yoilsho	6544	9	were	be	VBD
cord-006229-7yoilsho	6544	10	curated	curate	VBN
cord-006229-7yoilsho	6544	11	.	.	.
cord-006229-7yoilsho	6545	1	Additionally	additionally	RB
cord-006229-7yoilsho	6545	2	to	to	IN
cord-006229-7yoilsho	6545	3	the	the	DT
cord-006229-7yoilsho	6545	4	toxicology	toxicology	NN
cord-006229-7yoilsho	6545	5	database	database	NN
cord-006229-7yoilsho	6545	6	,	,	,
cord-006229-7yoilsho	6545	7	a	a	DT
cord-006229-7yoilsho	6545	8	web	web	NN
cord-006229-7yoilsho	6545	9	-	-	HYPH
cord-006229-7yoilsho	6545	10	based	base	VBN
cord-006229-7yoilsho	6545	11	user	user	NN
cord-006229-7yoilsho	6545	12	interface	interface	NN
cord-006229-7yoilsho	6545	13	called	call	VBN
cord-006229-7yoilsho	6545	14	eTOXsys	eTOXsys	NNP
cord-006229-7yoilsho	6545	15	was	be	VBD
cord-006229-7yoilsho	6545	16	developed	develop	VBN
cord-006229-7yoilsho	6545	17	to	to	TO
cord-006229-7yoilsho	6545	18	allow	allow	VB
cord-006229-7yoilsho	6545	19	the	the	DT
cord-006229-7yoilsho	6545	20	retrieving	retrieving	NN
cord-006229-7yoilsho	6545	21	of	of	IN
cord-006229-7yoilsho	6545	22	toxicity	toxicity	NN
cord-006229-7yoilsho	6545	23	information	information	NN
cord-006229-7yoilsho	6545	24	,	,	,
cord-006229-7yoilsho	6545	25	as	as	RB
cord-006229-7yoilsho	6545	26	well	well	RB
cord-006229-7yoilsho	6545	27	as	as	IN
cord-006229-7yoilsho	6545	28	the	the	DT
cord-006229-7yoilsho	6545	29	prediction	prediction	NN
cord-006229-7yoilsho	6545	30	of	of	IN
cord-006229-7yoilsho	6545	31	toxic	toxic	JJ
cord-006229-7yoilsho	6545	32	endpoints	endpoint	NNS
cord-006229-7yoilsho	6545	33	for	for	IN
cord-006229-7yoilsho	6545	34	chemical	chemical	JJ
cord-006229-7yoilsho	6545	35	compounds	compound	NNS
cord-006229-7yoilsho	6545	36	.	.	.
cord-006229-7yoilsho	6546	1	Due	due	IN
cord-006229-7yoilsho	6546	2	to	to	IN
cord-006229-7yoilsho	6546	3	the	the	DT
cord-006229-7yoilsho	6546	4	complex	complex	JJ
cord-006229-7yoilsho	6546	5	search	search	NN
cord-006229-7yoilsho	6546	6	capabilities	capability	NNS
cord-006229-7yoilsho	6546	7	,	,	,
cord-006229-7yoilsho	6546	8	the	the	DT
cord-006229-7yoilsho	6546	9	database	database	NN
cord-006229-7yoilsho	6546	10	can	can	MD
cord-006229-7yoilsho	6546	11	be	be	VB
cord-006229-7yoilsho	6546	12	queried	query	VBN
cord-006229-7yoilsho	6546	13	for	for	IN
cord-006229-7yoilsho	6546	14	structural	structural	JJ
cord-006229-7yoilsho	6546	15	similarity	similarity	NN
cord-006229-7yoilsho	6546	16	,	,	,
cord-006229-7yoilsho	6546	17	similar	similar	JJ
cord-006229-7yoilsho	6546	18	target	target	NN
cord-006229-7yoilsho	6546	19	classes	class	NNS
cord-006229-7yoilsho	6546	20	and	and	CC
cord-006229-7yoilsho	6546	21	specific	specific	JJ
cord-006229-7yoilsho	6546	22	toxicological	toxicological	JJ
cord-006229-7yoilsho	6546	23	endpoints	endpoint	NNS
cord-006229-7yoilsho	6546	24	.	.	.
cord-006229-7yoilsho	6547	1	Approximately	approximately	RB
cord-006229-7yoilsho	6547	2	150	150	CD
cord-006229-7yoilsho	6547	3	prediction	prediction	NN
cord-006229-7yoilsho	6547	4	models	model	NNS
cord-006229-7yoilsho	6547	5	based	base	VBN
cord-006229-7yoilsho	6547	6	on	on	IN
cord-006229-7yoilsho	6547	7	public	public	JJ
cord-006229-7yoilsho	6547	8	data	datum	NNS
cord-006229-7yoilsho	6547	9	are	be	VBP
cord-006229-7yoilsho	6547	10	available	available	JJ
cord-006229-7yoilsho	6547	11	and	and	CC
cord-006229-7yoilsho	6547	12	first	first	JJ
cord-006229-7yoilsho	6547	13	models	model	NNS
cord-006229-7yoilsho	6547	14	based	base	VBN
cord-006229-7yoilsho	6547	15	on	on	IN
cord-006229-7yoilsho	6547	16	in	in	IN
cord-006229-7yoilsho	6547	17	vivo	vivo	NN
cord-006229-7yoilsho	6547	18	data	datum	NNS
cord-006229-7yoilsho	6547	19	are	be	VBP
cord-006229-7yoilsho	6547	20	in	in	IN
cord-006229-7yoilsho	6547	21	development	development	NN
cord-006229-7yoilsho	6547	22	.	.	.
cord-006229-7yoilsho	6548	1	The	the	DT
cord-006229-7yoilsho	6548	2	eTOX	etox	CD
cord-006229-7yoilsho	6548	3	database	database	NN
cord-006229-7yoilsho	6548	4	therefore	therefore	RB
cord-006229-7yoilsho	6548	5	represents	represent	VBZ
cord-006229-7yoilsho	6548	6	a	a	DT
cord-006229-7yoilsho	6548	7	valuable	valuable	JJ
cord-006229-7yoilsho	6548	8	tool	tool	NN
cord-006229-7yoilsho	6548	9	for	for	IN
cord-006229-7yoilsho	6548	10	early	early	JJ
cord-006229-7yoilsho	6548	11	animal	animal	NN
cord-006229-7yoilsho	6548	12	-	-	HYPH
cord-006229-7yoilsho	6548	13	free	free	JJ
cord-006229-7yoilsho	6548	14	assessment	assessment	NN
cord-006229-7yoilsho	6548	15	of	of	IN
cord-006229-7yoilsho	6548	16	drug	drug	NN
cord-006229-7yoilsho	6548	17	candidates	candidate	NNS
cord-006229-7yoilsho	6548	18	[	[	-LRB-
cord-006229-7yoilsho	6548	19	5	5	CD
cord-006229-7yoilsho	6548	20	]	]	-RRB-
cord-006229-7yoilsho	6548	21	.	.	.
cord-006229-7yoilsho	6549	1	*	*	NFP
cord-006229-7yoilsho	6549	2	European	European	NNP
cord-006229-7yoilsho	6549	3	Federation	Federation	NNP
cord-006229-7yoilsho	6549	4	of	of	IN
cord-006229-7yoilsho	6549	5	Pharmaceutical	Pharmaceutical	NNP
cord-006229-7yoilsho	6549	6	Industries	Industries	NNPS
cord-006229-7yoilsho	6549	7	and	and	CC
cord-006229-7yoilsho	6549	8	Associations	Associations	NNPS
cord-006229-7yoilsho	6549	9	cell	cell	NN
cord-006229-7yoilsho	6549	10	lines	line	NNS
cord-006229-7yoilsho	6550	1	Background	background	NN
cord-006229-7yoilsho	6550	2	:	:	:
cord-006229-7yoilsho	6550	3	Consumers	consumer	NNS
cord-006229-7yoilsho	6550	4	are	be	VBP
cord-006229-7yoilsho	6550	5	constantly	constantly	RB
cord-006229-7yoilsho	6550	6	exposed	expose	VBN
cord-006229-7yoilsho	6550	7	to	to	IN
cord-006229-7yoilsho	6550	8	chemical	chemical	JJ
cord-006229-7yoilsho	6550	9	mixtures	mixture	NNS
cord-006229-7yoilsho	6550	10	e.	e.	NNP
cord-006229-7yoilsho	6550	11	g.	g.	NNP
cord-006229-7yoilsho	6550	12	to	to	IN
cord-006229-7yoilsho	6550	13	multiple	multiple	JJ
cord-006229-7yoilsho	6550	14	residues	residue	NNS
cord-006229-7yoilsho	6550	15	of	of	IN
cord-006229-7yoilsho	6550	16	different	different	JJ
cord-006229-7yoilsho	6550	17	pesticides	pesticide	NNS
cord-006229-7yoilsho	6550	18	via	via	IN
cord-006229-7yoilsho	6550	19	the	the	DT
cord-006229-7yoilsho	6550	20	diet	diet	NN
cord-006229-7yoilsho	6550	21	.	.	.
cord-006229-7yoilsho	6551	1	This	this	DT
cord-006229-7yoilsho	6551	2	raises	raise	VBZ
cord-006229-7yoilsho	6551	3	questions	question	NNS
cord-006229-7yoilsho	6551	4	concerning	concern	VBG
cord-006229-7yoilsho	6551	5	potential	potential	JJ
cord-006229-7yoilsho	6551	6	cumulative	cumulative	JJ
cord-006229-7yoilsho	6551	7	effects	effect	NNS
cord-006229-7yoilsho	6551	8	,	,	,
cord-006229-7yoilsho	6551	9	especially	especially	RB
cord-006229-7yoilsho	6551	10	for	for	IN
cord-006229-7yoilsho	6551	11	substances	substance	NNS
cord-006229-7yoilsho	6551	12	causing	cause	VBG
cord-006229-7yoilsho	6551	13	toxicity	toxicity	NN
cord-006229-7yoilsho	6551	14	by	by	IN
cord-006229-7yoilsho	6551	15	a	a	DT
cord-006229-7yoilsho	6551	16	common	common	JJ
cord-006229-7yoilsho	6551	17	mode	mode	NN
cord-006229-7yoilsho	6551	18	of	of	IN
cord-006229-7yoilsho	6551	19	action	action	NN
cord-006229-7yoilsho	6551	20	.	.	.
cord-006229-7yoilsho	6552	1	Since	since	IN
cord-006229-7yoilsho	6552	2	substances	substance	NNS
cord-006229-7yoilsho	6552	3	are	be	VBP
cord-006229-7yoilsho	6552	4	tested	test	VBN
cord-006229-7yoilsho	6552	5	for	for	IN
cord-006229-7yoilsho	6552	6	regulatory	regulatory	JJ
cord-006229-7yoilsho	6552	7	purposes	purpose	NNS
cord-006229-7yoilsho	6552	8	on	on	IN
cord-006229-7yoilsho	6552	9	an	an	DT
cord-006229-7yoilsho	6552	10	individual	individual	JJ
cord-006229-7yoilsho	6552	11	basis	basis	NN
cord-006229-7yoilsho	6552	12	at	at	IN
cord-006229-7yoilsho	6552	13	generally	generally	RB
cord-006229-7yoilsho	6552	14	high	high	JJ
cord-006229-7yoilsho	6552	15	dose	dose	NN
cord-006229-7yoilsho	6552	16	levels	level	NNS
cord-006229-7yoilsho	6552	17	,	,	,
cord-006229-7yoilsho	6552	18	there	there	EX
cord-006229-7yoilsho	6552	19	is	be	VBZ
cord-006229-7yoilsho	6552	20	only	only	RB
cord-006229-7yoilsho	6552	21	limited	limited	JJ
cord-006229-7yoilsho	6552	22	data	datum	NNS
cord-006229-7yoilsho	6552	23	available	available	JJ
cord-006229-7yoilsho	6552	24	on	on	IN
cord-006229-7yoilsho	6552	25	potential	potential	JJ
cord-006229-7yoilsho	6552	26	mixture	mixture	NN
cord-006229-7yoilsho	6552	27	effects	effect	NNS
cord-006229-7yoilsho	6552	28	especially	especially	RB
cord-006229-7yoilsho	6552	29	in	in	IN
cord-006229-7yoilsho	6552	30	the	the	DT
cord-006229-7yoilsho	6552	31	low	low	JJ
cord-006229-7yoilsho	6552	32	dose	dose	NN
cord-006229-7yoilsho	6552	33	range	range	NN
cord-006229-7yoilsho	6552	34	.	.	.
cord-006229-7yoilsho	6553	1	With	with	IN
cord-006229-7yoilsho	6553	2	more	more	JJR
cord-006229-7yoilsho	6553	3	than	than	IN
cord-006229-7yoilsho	6553	4	400	400	CD
cord-006229-7yoilsho	6553	5	active	active	JJ
cord-006229-7yoilsho	6553	6	substances	substance	NNS
cord-006229-7yoilsho	6553	7	approved	approve	VBN
cord-006229-7yoilsho	6553	8	for	for	IN
cord-006229-7yoilsho	6553	9	being	be	VBG
cord-006229-7yoilsho	6553	10	used	use	VBN
cord-006229-7yoilsho	6553	11	in	in	IN
cord-006229-7yoilsho	6553	12	pesticides	pesticide	NNS
cord-006229-7yoilsho	6553	13	and	and	CC
cord-006229-7yoilsho	6553	14	over	over	IN
cord-006229-7yoilsho	6553	15	100000	100000	CD
cord-006229-7yoilsho	6553	16	chemicals	chemical	NNS
cord-006229-7yoilsho	6553	17	registered	register	VBN
cord-006229-7yoilsho	6553	18	under	under	IN
cord-006229-7yoilsho	6553	19	REACH	reach	NN
cord-006229-7yoilsho	6553	20	there	there	EX
cord-006229-7yoilsho	6553	21	are	be	VBP
cord-006229-7yoilsho	6553	22	more	more	RBR
cord-006229-7yoilsho	6553	23	possible	possible	JJ
cord-006229-7yoilsho	6553	24	combinations	combination	NNS
cord-006229-7yoilsho	6553	25	than	than	IN
cord-006229-7yoilsho	6553	26	one	one	PRP
cord-006229-7yoilsho	6553	27	could	could	MD
cord-006229-7yoilsho	6553	28	test	test	VB
cord-006229-7yoilsho	6553	29	with	with	IN
cord-006229-7yoilsho	6553	30	classical	classical	JJ
cord-006229-7yoilsho	6553	31	animal	animal	NN
cord-006229-7yoilsho	6553	32	experiments	experiment	NNS
cord-006229-7yoilsho	6553	33	.	.	.
cord-006229-7yoilsho	6554	1	The	the	DT
cord-006229-7yoilsho	6554	2	development	development	NN
cord-006229-7yoilsho	6554	3	of	of	IN
cord-006229-7yoilsho	6554	4	in	in	FW
cord-006229-7yoilsho	6554	5	vitro	vitro	FW
cord-006229-7yoilsho	6554	6	tools	tool	NNS
cord-006229-7yoilsho	6554	7	for	for	IN
cord-006229-7yoilsho	6554	8	assessment	assessment	NN
cord-006229-7yoilsho	6554	9	of	of	IN
cord-006229-7yoilsho	6554	10	mixture	mixture	NN
cord-006229-7yoilsho	6554	11	effects	effect	NNS
cord-006229-7yoilsho	6554	12	consequently	consequently	RB
cord-006229-7yoilsho	6554	13	is	be	VBZ
cord-006229-7yoilsho	6554	14	of	of	IN
cord-006229-7yoilsho	6554	15	tremendous	tremendous	JJ
cord-006229-7yoilsho	6554	16	importance	importance	NN
cord-006229-7yoilsho	6554	17	.	.	.
cord-006229-7yoilsho	6555	1	Methods	method	NNS
cord-006229-7yoilsho	6555	2	:	:	:
cord-006229-7yoilsho	6556	1	As	as	IN
cord-006229-7yoilsho	6556	2	a	a	DT
cord-006229-7yoilsho	6556	3	first	first	JJ
cord-006229-7yoilsho	6556	4	step	step	NN
cord-006229-7yoilsho	6556	5	in	in	IN
cord-006229-7yoilsho	6556	6	the	the	DT
cord-006229-7yoilsho	6556	7	development	development	NN
cord-006229-7yoilsho	6556	8	of	of	IN
cord-006229-7yoilsho	6556	9	such	such	JJ
cord-006229-7yoilsho	6556	10	in	in	IN
cord-006229-7yoilsho	6556	11	vitro	vitro	FW
cord-006229-7yoilsho	6556	12	tools	tool	NNS
cord-006229-7yoilsho	6556	13	we	-PRON-	PRP
cord-006229-7yoilsho	6556	14	used	use	VBD
cord-006229-7yoilsho	6556	15	a	a	DT
cord-006229-7yoilsho	6556	16	group	group	NN
cord-006229-7yoilsho	6556	17	of	of	IN
cord-006229-7yoilsho	6556	18	fungicides	fungicide	NNS
cord-006229-7yoilsho	6556	19	,	,	,
cord-006229-7yoilsho	6556	20	(	(	-LRB-
cord-006229-7yoilsho	6556	21	tri-)azoles	tri-)azoles	NNP
cord-006229-7yoilsho	6556	22	,	,	,
cord-006229-7yoilsho	6556	23	as	as	IN
cord-006229-7yoilsho	6556	24	model	model	NN
cord-006229-7yoilsho	6556	25	substances	substance	NNS
cord-006229-7yoilsho	6556	26	in	in	IN
cord-006229-7yoilsho	6556	27	a	a	DT
cord-006229-7yoilsho	6556	28	set	set	NN
cord-006229-7yoilsho	6556	29	of	of	IN
cord-006229-7yoilsho	6556	30	different	different	JJ
cord-006229-7yoilsho	6556	31	cell	cell	NN
cord-006229-7yoilsho	6556	32	lines	line	NNS
cord-006229-7yoilsho	6556	33	from	from	IN
cord-006229-7yoilsho	6556	34	known	know	VBN
cord-006229-7yoilsho	6556	35	target	target	NN
cord-006229-7yoilsho	6556	36	tissues	tissue	NNS
cord-006229-7yoilsho	6556	37	,	,	,
cord-006229-7yoilsho	6556	38	basically	basically	RB
cord-006229-7yoilsho	6556	39	liver	liver	NN
cord-006229-7yoilsho	6556	40	(	(	-LRB-
cord-006229-7yoilsho	6556	41	human	human	NN
cord-006229-7yoilsho	6556	42	:	:	:
cord-006229-7yoilsho	6556	43	HepG2	HepG2	NNP
cord-006229-7yoilsho	6556	44	,	,	,
cord-006229-7yoilsho	6556	45	HepaRG	HepaRG	NNP
cord-006229-7yoilsho	6556	46	,	,	,
cord-006229-7yoilsho	6556	47	rat	rat	NN
cord-006229-7yoilsho	6556	48	:	:	:
cord-006229-7yoilsho	6556	49	H4IIE	H4IIE	NNP
cord-006229-7yoilsho	6556	50	)	)	-RRB-
cord-006229-7yoilsho	6556	51	and	and	CC
cord-006229-7yoilsho	6556	52	adrenal	adrenal	JJ
cord-006229-7yoilsho	6556	53	gland	gland	NN
cord-006229-7yoilsho	6556	54	(	(	-LRB-
cord-006229-7yoilsho	6556	55	human	human	NN
cord-006229-7yoilsho	6556	56	:	:	:
cord-006229-7yoilsho	6556	57	H295R	H295R	NNP
cord-006229-7yoilsho	6556	58	)	)	-RRB-
cord-006229-7yoilsho	6556	59	.	.	.
cord-006229-7yoilsho	6557	1	Concentrations	concentration	NNS
cord-006229-7yoilsho	6557	2	were	be	VBD
cord-006229-7yoilsho	6557	3	taken	take	VBN
cord-006229-7yoilsho	6557	4	from	from	IN
cord-006229-7yoilsho	6557	5	measured	measure	VBN
cord-006229-7yoilsho	6557	6	tissue	tissue	NN
cord-006229-7yoilsho	6557	7	concentrations	concentration	NNS
cord-006229-7yoilsho	6557	8	in	in	IN
cord-006229-7yoilsho	6557	9	vivo	vivo	NN
cord-006229-7yoilsho	6557	10	to	to	TO
cord-006229-7yoilsho	6557	11	ensure	ensure	VB
cord-006229-7yoilsho	6557	12	that	that	IN
cord-006229-7yoilsho	6557	13	used	use	VBN
cord-006229-7yoilsho	6557	14	concentrations	concentration	NNS
cord-006229-7yoilsho	6557	15	of	of	IN
cord-006229-7yoilsho	6557	16	the	the	DT
cord-006229-7yoilsho	6557	17	(	(	-LRB-
cord-006229-7yoilsho	6557	18	tri-	tri-	NN
cord-006229-7yoilsho	6557	19	)	)	-RRB-
cord-006229-7yoilsho	6557	20	azoles	azole	NNS
cord-006229-7yoilsho	6557	21	reflect	reflect	VBP
cord-006229-7yoilsho	6557	22	realistic	realistic	JJ
cord-006229-7yoilsho	6557	23	effect	effect	NN
cord-006229-7yoilsho	6557	24	levels	level	NNS
cord-006229-7yoilsho	6557	25	.	.	.
cord-006229-7yoilsho	6558	1	The	the	DT
cord-006229-7yoilsho	6558	2	cell	cell	NN
cord-006229-7yoilsho	6558	3	lines	line	NNS
cord-006229-7yoilsho	6558	4	were	be	VBD
cord-006229-7yoilsho	6558	5	exposed	expose	VBN
cord-006229-7yoilsho	6558	6	with	with	IN
cord-006229-7yoilsho	6558	7	the	the	DT
cord-006229-7yoilsho	6558	8	triazoles	triazoles	NNP
cord-006229-7yoilsho	6558	9	cyproconazole	cyproconazole	NNP
cord-006229-7yoilsho	6558	10	and	and	CC
cord-006229-7yoilsho	6558	11	epoxiconazole	epoxiconazole	NN
cord-006229-7yoilsho	6558	12	as	as	RB
cord-006229-7yoilsho	6558	13	well	well	RB
cord-006229-7yoilsho	6558	14	as	as	IN
cord-006229-7yoilsho	6558	15	with	with	IN
cord-006229-7yoilsho	6558	16	the	the	DT
cord-006229-7yoilsho	6558	17	azole	azole	NNP
cord-006229-7yoilsho	6558	18	prochloraz	prochloraz	NN
cord-006229-7yoilsho	6558	19	as	as	IN
cord-006229-7yoilsho	6558	20	individual	individual	JJ
cord-006229-7yoilsho	6558	21	substances	substance	NNS
cord-006229-7yoilsho	6558	22	and	and	CC
cord-006229-7yoilsho	6558	23	in	in	IN
cord-006229-7yoilsho	6558	24	binary	binary	JJ
cord-006229-7yoilsho	6558	25	or	or	CC
cord-006229-7yoilsho	6558	26	ternary	ternary	JJ
cord-006229-7yoilsho	6558	27	combinations	combination	NNS
cord-006229-7yoilsho	6558	28	of	of	IN
cord-006229-7yoilsho	6558	29	these	these	DT
cord-006229-7yoilsho	6558	30	substances	substance	NNS
cord-006229-7yoilsho	6558	31	at	at	IN
cord-006229-7yoilsho	6558	32	three	three	CD
cord-006229-7yoilsho	6558	33	dose	dose	NN
cord-006229-7yoilsho	6558	34	levels	level	NNS
cord-006229-7yoilsho	6558	35	and	and	CC
cord-006229-7yoilsho	6558	36	three	three	CD
cord-006229-7yoilsho	6558	37	different	different	JJ
cord-006229-7yoilsho	6558	38	time	time	NN
cord-006229-7yoilsho	6558	39	periods	period	NNS
cord-006229-7yoilsho	6558	40	.	.	.
cord-006229-7yoilsho	6559	1	The	the	DT
cord-006229-7yoilsho	6559	2	effects	effect	NNS
cord-006229-7yoilsho	6559	3	of	of	IN
cord-006229-7yoilsho	6559	4	the	the	DT
cord-006229-7yoilsho	6559	5	substances	substance	NNS
cord-006229-7yoilsho	6559	6	were	be	VBD
cord-006229-7yoilsho	6559	7	subsequently	subsequently	RB
cord-006229-7yoilsho	6559	8	analysed	analyse	VBN
cord-006229-7yoilsho	6559	9	by	by	IN
cord-006229-7yoilsho	6559	10	transcriptomics	transcriptomic	NNS
cord-006229-7yoilsho	6559	11	and	and	CC
cord-006229-7yoilsho	6559	12	metabolomics	metabolomic	NNS
cord-006229-7yoilsho	6559	13	.	.	.
cord-006229-7yoilsho	6560	1	A	a	DT
cord-006229-7yoilsho	6560	2	support	support	NN
cord-006229-7yoilsho	6560	3	vector	vector	NN
cord-006229-7yoilsho	6560	4	machine	machine	NN
cord-006229-7yoilsho	6560	5	will	will	MD
cord-006229-7yoilsho	6560	6	be	be	VB
cord-006229-7yoilsho	6560	7	utilized	utilize	VBN
cord-006229-7yoilsho	6560	8	to	to	TO
cord-006229-7yoilsho	6560	9	integrate	integrate	VB
cord-006229-7yoilsho	6560	10	the	the	DT
cord-006229-7yoilsho	6560	11	data	datum	NNS
cord-006229-7yoilsho	6560	12	from	from	IN
cord-006229-7yoilsho	6560	13	the	the	DT
cord-006229-7yoilsho	6560	14	different	different	JJ
cord-006229-7yoilsho	6560	15	sources	source	NNS
cord-006229-7yoilsho	6560	16	to	to	TO
cord-006229-7yoilsho	6560	17	gain	gain	VB
cord-006229-7yoilsho	6560	18	a	a	DT
cord-006229-7yoilsho	6560	19	complete	complete	JJ
cord-006229-7yoilsho	6560	20	picture	picture	NN
cord-006229-7yoilsho	6560	21	of	of	IN
cord-006229-7yoilsho	6560	22	affected	affected	JJ
cord-006229-7yoilsho	6560	23	adverse	adverse	JJ
cord-006229-7yoilsho	6560	24	outcome	outcome	NN
cord-006229-7yoilsho	6560	25	pathways	pathway	NNS
cord-006229-7yoilsho	6560	26	and	and	CC
cord-006229-7yoilsho	6560	27	mechanistic	mechanistic	JJ
cord-006229-7yoilsho	6560	28	information	information	NN
cord-006229-7yoilsho	6560	29	about	about	IN
cord-006229-7yoilsho	6560	30	the	the	DT
cord-006229-7yoilsho	6560	31	applied	apply	VBN
cord-006229-7yoilsho	6560	32	fungicides	fungicide	NNS
cord-006229-7yoilsho	6560	33	.	.	.
cord-006229-7yoilsho	6561	1	First	first	JJ
cord-006229-7yoilsho	6561	2	results	result	NNS
cord-006229-7yoilsho	6561	3	indicate	indicate	VBP
cord-006229-7yoilsho	6561	4	combination	combination	NN
cord-006229-7yoilsho	6561	5	effects	effect	NNS
cord-006229-7yoilsho	6561	6	of	of	IN
cord-006229-7yoilsho	6561	7	the	the	DT
cord-006229-7yoilsho	6561	8	substances	substance	NNS
cord-006229-7yoilsho	6561	9	also	also	RB
cord-006229-7yoilsho	6561	10	at	at	IN
cord-006229-7yoilsho	6561	11	the	the	DT
cord-006229-7yoilsho	6561	12	omics	omic	NNS
cord-006229-7yoilsho	6561	13	level	level	NN
cord-006229-7yoilsho	6561	14	depending	depend	VBG
cord-006229-7yoilsho	6561	15	on	on	IN
cord-006229-7yoilsho	6561	16	the	the	DT
cord-006229-7yoilsho	6561	17	specific	specific	JJ
cord-006229-7yoilsho	6561	18	endpoint	endpoint	NN
cord-006229-7yoilsho	6561	19	and	and	CC
cord-006229-7yoilsho	6561	20	the	the	DT
cord-006229-7yoilsho	6561	21	concentration	concentration	NN
cord-006229-7yoilsho	6561	22	used	use	VBN
cord-006229-7yoilsho	6561	23	.	.	.
cord-006229-7yoilsho	6562	1	Some	some	DT
cord-006229-7yoilsho	6562	2	of	of	IN
cord-006229-7yoilsho	6562	3	these	these	DT
cord-006229-7yoilsho	6562	4	are	be	VBP
cord-006229-7yoilsho	6562	5	comparable	comparable	JJ
cord-006229-7yoilsho	6562	6	to	to	IN
cord-006229-7yoilsho	6562	7	effects	effect	NNS
cord-006229-7yoilsho	6562	8	found	find	VBN
cord-006229-7yoilsho	6562	9	with	with	IN
cord-006229-7yoilsho	6562	10	similar	similar	JJ
cord-006229-7yoilsho	6562	11	methods	method	NNS
cord-006229-7yoilsho	6562	12	in	in	IN
cord-006229-7yoilsho	6562	13	a	a	DT
cord-006229-7yoilsho	6562	14	standard	standard	JJ
cord-006229-7yoilsho	6562	15	toxicity	toxicity	NN
cord-006229-7yoilsho	6562	16	test	test	NN
cord-006229-7yoilsho	6562	17	,	,	,
cord-006229-7yoilsho	6562	18	a	a	DT
cord-006229-7yoilsho	6562	19	28-day	28-day	CD
cord-006229-7yoilsho	6562	20	feeding	feeding	NN
cord-006229-7yoilsho	6562	21	study	study	NN
cord-006229-7yoilsho	6562	22	in	in	IN
cord-006229-7yoilsho	6562	23	the	the	DT
cord-006229-7yoilsho	6562	24	rat	rat	NN
cord-006229-7yoilsho	6562	25	,	,	,
cord-006229-7yoilsho	6562	26	thus	thus	RB
cord-006229-7yoilsho	6562	27	raising	raise	VBG
cord-006229-7yoilsho	6562	28	hope	hope	NN
cord-006229-7yoilsho	6562	29	for	for	IN
cord-006229-7yoilsho	6562	30	the	the	DT
cord-006229-7yoilsho	6562	31	development	development	NN
cord-006229-7yoilsho	6562	32	of	of	IN
cord-006229-7yoilsho	6562	33	in	in	FW
cord-006229-7yoilsho	6562	34	vitro	vitro	FW
cord-006229-7yoilsho	6562	35	methods	method	NNS
cord-006229-7yoilsho	6562	36	suitable	suitable	JJ
cord-006229-7yoilsho	6562	37	to	to	TO
cord-006229-7yoilsho	6562	38	detect	detect	VB
cord-006229-7yoilsho	6562	39	combination	combination	NN
cord-006229-7yoilsho	6562	40	effects	effect	NNS
cord-006229-7yoilsho	6562	41	.	.	.
cord-006229-7yoilsho	6563	1	Background	background	NN
cord-006229-7yoilsho	6563	2	:	:	:
cord-006229-7yoilsho	6564	1	Plant	plant	NN
cord-006229-7yoilsho	6564	2	protection	protection	NN
cord-006229-7yoilsho	6564	3	and	and	CC
cord-006229-7yoilsho	6564	4	biocide	biocide	NN
cord-006229-7yoilsho	6564	5	products	product	NNS
cord-006229-7yoilsho	6564	6	are	be	VBP
cord-006229-7yoilsho	6564	7	chemical	chemical	JJ
cord-006229-7yoilsho	6564	8	mixtures	mixture	NNS
cord-006229-7yoilsho	6564	9	,	,	,
cord-006229-7yoilsho	6564	10	which	which	WDT
cord-006229-7yoilsho	6564	11	contain	contain	VBP
cord-006229-7yoilsho	6564	12	one	one	CD
cord-006229-7yoilsho	6564	13	or	or	CC
cord-006229-7yoilsho	6564	14	more	more	JJR
cord-006229-7yoilsho	6564	15	active	active	JJ
cord-006229-7yoilsho	6564	16	substances	substance	NNS
cord-006229-7yoilsho	6564	17	as	as	RB
cord-006229-7yoilsho	6564	18	well	well	RB
cord-006229-7yoilsho	6564	19	as	as	IN
cord-006229-7yoilsho	6564	20	several	several	JJ
cord-006229-7yoilsho	6564	21	co	co	NNS
cord-006229-7yoilsho	6564	22	-	-	NN
cord-006229-7yoilsho	6564	23	formulants	formulant	NNS
cord-006229-7yoilsho	6564	24	(	(	-LRB-
cord-006229-7yoilsho	6564	25	e.g.	e.g.	IN
cord-006229-7yoilsho	6564	26	solvents	solvent	NNS
cord-006229-7yoilsho	6564	27	,	,	,
cord-006229-7yoilsho	6564	28	wetting	wet	VBG
cord-006229-7yoilsho	6564	29	agents	agent	NNS
cord-006229-7yoilsho	6564	30	,	,	,
cord-006229-7yoilsho	6564	31	thickener	thickener	NN
cord-006229-7yoilsho	6564	32	or	or	CC
cord-006229-7yoilsho	6564	33	preservatives	preservative	NNS
cord-006229-7yoilsho	6564	34	)	)	-RRB-
cord-006229-7yoilsho	6564	35	.	.	.
cord-006229-7yoilsho	6565	1	Nevertheless	nevertheless	RB
cord-006229-7yoilsho	6565	2	,	,	,
cord-006229-7yoilsho	6565	3	to	to	IN
cord-006229-7yoilsho	6565	4	this	this	DT
cord-006229-7yoilsho	6565	5	day	day	NN
cord-006229-7yoilsho	6565	6	extensive	extensive	JJ
cord-006229-7yoilsho	6565	7	toxicological	toxicological	JJ
cord-006229-7yoilsho	6565	8	testing	testing	NN
cord-006229-7yoilsho	6565	9	is	be	VBZ
cord-006229-7yoilsho	6565	10	performed	perform	VBN
cord-006229-7yoilsho	6565	11	only	only	RB
cord-006229-7yoilsho	6565	12	with	with	IN
cord-006229-7yoilsho	6565	13	the	the	DT
cord-006229-7yoilsho	6565	14	individual	individual	JJ
cord-006229-7yoilsho	6565	15	active	active	JJ
cord-006229-7yoilsho	6565	16	substances	substance	NNS
cord-006229-7yoilsho	6565	17	,	,	,
cord-006229-7yoilsho	6565	18	while	while	IN
cord-006229-7yoilsho	6565	19	the	the	DT
cord-006229-7yoilsho	6565	20	plant	plant	NN
cord-006229-7yoilsho	6565	21	protection	protection	NN
cord-006229-7yoilsho	6565	22	products	product	NNS
cord-006229-7yoilsho	6565	23	are	be	VBP
cord-006229-7yoilsho	6565	24	only	only	RB
cord-006229-7yoilsho	6565	25	evaluated	evaluate	VBN
cord-006229-7yoilsho	6565	26	for	for	IN
cord-006229-7yoilsho	6565	27	acute	acute	JJ
cord-006229-7yoilsho	6565	28	toxicity	toxicity	NN
cord-006229-7yoilsho	6565	29	,	,	,
cord-006229-7yoilsho	6565	30	ie	ie	FW
cord-006229-7yoilsho	6565	31	,	,	,
cord-006229-7yoilsho	6565	32	a	a	DT
cord-006229-7yoilsho	6565	33	single	single	JJ
cord-006229-7yoilsho	6565	34	dose	dose	NN
cord-006229-7yoilsho	6565	35	group	group	NN
cord-006229-7yoilsho	6565	36	experiment	experiment	NN
cord-006229-7yoilsho	6565	37	with	with	IN
cord-006229-7yoilsho	6565	38	rats	rat	NNS
cord-006229-7yoilsho	6565	39	is	be	VBZ
cord-006229-7yoilsho	6565	40	performed	perform	VBN
cord-006229-7yoilsho	6565	41	as	as	RB
cord-006229-7yoilsho	6565	42	well	well	RB
cord-006229-7yoilsho	6565	43	as	as	IN
cord-006229-7yoilsho	6565	44	testing	test	VBG
cord-006229-7yoilsho	6565	45	for	for	IN
cord-006229-7yoilsho	6565	46	skin	skin	NN
cord-006229-7yoilsho	6565	47	-	-	HYPH
cord-006229-7yoilsho	6565	48	and	and	CC
cord-006229-7yoilsho	6565	49	eye	eye	NN
cord-006229-7yoilsho	6565	50	-	-	HYPH
cord-006229-7yoilsho	6565	51	irritation	irritation	NN
cord-006229-7yoilsho	6565	52	.	.	.
cord-006229-7yoilsho	6566	1	Current	current	JJ
cord-006229-7yoilsho	6566	2	pesticides	pesticide	NNS
cord-006229-7yoilsho	6566	3	regulation	regulation	NN
cord-006229-7yoilsho	6566	4	foresees	foresee	VBZ
cord-006229-7yoilsho	6566	5	testing	testing	NN
cord-006229-7yoilsho	6566	6	of	of	IN
cord-006229-7yoilsho	6566	7	potential	potential	JJ
cord-006229-7yoilsho	6566	8	harmful	harmful	JJ
cord-006229-7yoilsho	6566	9	mixture	mixture	NN
cord-006229-7yoilsho	6566	10	effects	effect	NNS
cord-006229-7yoilsho	6566	11	but	but	CC
cord-006229-7yoilsho	6566	12	only	only	RB
cord-006229-7yoilsho	6566	13	when	when	WRB
cord-006229-7yoilsho	6566	14	adequate	adequate	JJ
cord-006229-7yoilsho	6566	15	methods	method	NNS
cord-006229-7yoilsho	6566	16	are	be	VBP
cord-006229-7yoilsho	6566	17	available	available	JJ
cord-006229-7yoilsho	6566	18	making	make	VBG
cord-006229-7yoilsho	6566	19	the	the	DT
cord-006229-7yoilsho	6566	20	development	development	NN
cord-006229-7yoilsho	6566	21	of	of	IN
cord-006229-7yoilsho	6566	22	such	such	JJ
cord-006229-7yoilsho	6566	23	methods	method	NNS
cord-006229-7yoilsho	6566	24	a	a	DT
cord-006229-7yoilsho	6566	25	high	high	JJ
cord-006229-7yoilsho	6566	26	priority	priority	NN
cord-006229-7yoilsho	6566	27	.	.	.
cord-006229-7yoilsho	6567	1	Several	several	JJ
cord-006229-7yoilsho	6567	2	published	publish	VBN
cord-006229-7yoilsho	6567	3	studies	study	NNS
cord-006229-7yoilsho	6567	4	both	both	DT
cord-006229-7yoilsho	6567	5	in	in	IN
cord-006229-7yoilsho	6567	6	vitro	vitro	FW
cord-006229-7yoilsho	6567	7	and	and	CC
cord-006229-7yoilsho	6567	8	in	in	IN
cord-006229-7yoilsho	6567	9	vivo	vivo	NN
cord-006229-7yoilsho	6567	10	have	have	VBP
cord-006229-7yoilsho	6567	11	shown	show	VBN
cord-006229-7yoilsho	6567	12	fortified	fortify	VBN
cord-006229-7yoilsho	6567	13	toxic	toxic	JJ
cord-006229-7yoilsho	6567	14	effects	effect	NNS
cord-006229-7yoilsho	6567	15	of	of	IN
cord-006229-7yoilsho	6567	16	plant	plant	NN
cord-006229-7yoilsho	6567	17	protection	protection	NN
cord-006229-7yoilsho	6567	18	products	product	NNS
cord-006229-7yoilsho	6567	19	compared	compare	VBN
cord-006229-7yoilsho	6567	20	to	to	IN
cord-006229-7yoilsho	6567	21	individual	individual	JJ
cord-006229-7yoilsho	6567	22	active	active	JJ
cord-006229-7yoilsho	6567	23	substances	substance	NNS
cord-006229-7yoilsho	6567	24	.	.	.
cord-006229-7yoilsho	6568	1	Methods	method	NNS
cord-006229-7yoilsho	6568	2	:	:	:
cord-006229-7yoilsho	6569	1	Here	here	RB
cord-006229-7yoilsho	6569	2	we	-PRON-	PRP
cord-006229-7yoilsho	6569	3	present	present	VBP
cord-006229-7yoilsho	6569	4	effects	effect	NNS
cord-006229-7yoilsho	6569	5	of	of	IN
cord-006229-7yoilsho	6569	6	plant	plant	NN
cord-006229-7yoilsho	6569	7	protection	protection	NN
cord-006229-7yoilsho	6569	8	products	product	NNS
cord-006229-7yoilsho	6569	9	as	as	IN
cord-006229-7yoilsho	6569	10	a	a	DT
cord-006229-7yoilsho	6569	11	whole	whole	NN
cord-006229-7yoilsho	6569	12	as	as	IN
cord-006229-7yoilsho	6569	13	compared	compare	VBN
cord-006229-7yoilsho	6569	14	to	to	IN
cord-006229-7yoilsho	6569	15	the	the	DT
cord-006229-7yoilsho	6569	16	individual	individual	JJ
cord-006229-7yoilsho	6569	17	active	active	JJ
cord-006229-7yoilsho	6569	18	substances	substance	NNS
cord-006229-7yoilsho	6569	19	or	or	CC
cord-006229-7yoilsho	6569	20	co	co	NNS
cord-006229-7yoilsho	6569	21	-	-	NN
cord-006229-7yoilsho	6569	22	formulants	formulant	NNS
cord-006229-7yoilsho	6569	23	in	in	IN
cord-006229-7yoilsho	6569	24	a	a	DT
cord-006229-7yoilsho	6569	25	set	set	NN
cord-006229-7yoilsho	6569	26	of	of	IN
cord-006229-7yoilsho	6569	27	human	human	JJ
cord-006229-7yoilsho	6569	28	cell	cell	NN
cord-006229-7yoilsho	6569	29	lines	line	NNS
cord-006229-7yoilsho	6569	30	of	of	IN
cord-006229-7yoilsho	6569	31	hepatic	hepatic	JJ
cord-006229-7yoilsho	6569	32	and	and	CC
cord-006229-7yoilsho	6569	33	renal	renal	JJ
cord-006229-7yoilsho	6569	34	origin	origin	NN
cord-006229-7yoilsho	6569	35	(	(	-LRB-
cord-006229-7yoilsho	6569	36	HepG2	HepG2	NNP
cord-006229-7yoilsho	6569	37	,	,	,
cord-006229-7yoilsho	6569	38	HepaRG	HepaRG	NNP
cord-006229-7yoilsho	6569	39	,	,	,
cord-006229-7yoilsho	6569	40	HEK293	HEK293	NNP
cord-006229-7yoilsho	6569	41	)	)	-RRB-
cord-006229-7yoilsho	6569	42	.	.	.
cord-006229-7yoilsho	6570	1	Cytoxicity	Cytoxicity	NNP
cord-006229-7yoilsho	6570	2	has	have	VBZ
cord-006229-7yoilsho	6570	3	been	be	VBN
cord-006229-7yoilsho	6570	4	analysed	analyse	VBN
cord-006229-7yoilsho	6570	5	by	by	IN
cord-006229-7yoilsho	6570	6	WST-1	WST-1	NNP
cord-006229-7yoilsho	6570	7	and	and	CC
cord-006229-7yoilsho	6570	8	NRU	NRU	NNP
cord-006229-7yoilsho	6570	9	assay	assay	NN
cord-006229-7yoilsho	6570	10	as	as	RB
cord-006229-7yoilsho	6570	11	well	well	RB
cord-006229-7yoilsho	6570	12	as	as	IN
cord-006229-7yoilsho	6570	13	gene	gene	NN
cord-006229-7yoilsho	6570	14	expression	expression	NN
cord-006229-7yoilsho	6570	15	of	of	IN
cord-006229-7yoilsho	6570	16	several	several	JJ
cord-006229-7yoilsho	6570	17	marker	marker	NN
cord-006229-7yoilsho	6570	18	genes	gene	NNS
cord-006229-7yoilsho	6570	19	involved	involve	VBN
cord-006229-7yoilsho	6570	20	in	in	IN
cord-006229-7yoilsho	6570	21	xenobiotic	xenobiotic	JJ
cord-006229-7yoilsho	6570	22	metabolism	metabolism	NN
cord-006229-7yoilsho	6570	23	.	.	.
cord-006229-7yoilsho	6571	1	Additionally	additionally	RB
cord-006229-7yoilsho	6571	2	reporter	reporter	NN
cord-006229-7yoilsho	6571	3	gene	gene	NN
cord-006229-7yoilsho	6571	4	assays	assay	NNS
cord-006229-7yoilsho	6571	5	have	have	VBP
cord-006229-7yoilsho	6571	6	been	be	VBN
cord-006229-7yoilsho	6571	7	conducted	conduct	VBN
cord-006229-7yoilsho	6571	8	for	for	IN
cord-006229-7yoilsho	6571	9	nuclear	nuclear	JJ
cord-006229-7yoilsho	6571	10	receptors	receptor	NNS
cord-006229-7yoilsho	6571	11	such	such	JJ
cord-006229-7yoilsho	6571	12	as	as	IN
cord-006229-7yoilsho	6571	13	AhR	ahr	NN
cord-006229-7yoilsho	6571	14	and	and	CC
cord-006229-7yoilsho	6571	15	CAR	car	NN
cord-006229-7yoilsho	6571	16	.	.	.
cord-006229-7yoilsho	6572	1	Results	result	NNS
cord-006229-7yoilsho	6572	2	:	:	:
cord-006229-7yoilsho	6572	3	While	while	IN
cord-006229-7yoilsho	6572	4	some	some	DT
cord-006229-7yoilsho	6572	5	active	active	JJ
cord-006229-7yoilsho	6572	6	substances	substance	NNS
cord-006229-7yoilsho	6572	7	showed	show	VBD
cord-006229-7yoilsho	6572	8	lower	low	JJR
cord-006229-7yoilsho	6572	9	toxicity	toxicity	NN
cord-006229-7yoilsho	6572	10	as	as	IN
cord-006229-7yoilsho	6572	11	compared	compare	VBN
cord-006229-7yoilsho	6572	12	to	to	IN
cord-006229-7yoilsho	6572	13	the	the	DT
cord-006229-7yoilsho	6572	14	respective	respective	JJ
cord-006229-7yoilsho	6572	15	products	product	NNS
cord-006229-7yoilsho	6572	16	,	,	,
cord-006229-7yoilsho	6572	17	this	this	DT
cord-006229-7yoilsho	6572	18	can	can	MD
cord-006229-7yoilsho	6572	19	not	not	RB
cord-006229-7yoilsho	6572	20	be	be	VB
cord-006229-7yoilsho	6572	21	confirmed	confirm	VBN
cord-006229-7yoilsho	6572	22	as	as	IN
cord-006229-7yoilsho	6572	23	a	a	DT
cord-006229-7yoilsho	6572	24	general	general	JJ
cord-006229-7yoilsho	6572	25	rule	rule	NN
cord-006229-7yoilsho	6572	26	for	for	IN
cord-006229-7yoilsho	6572	27	all	all	DT
cord-006229-7yoilsho	6572	28	endpoints	endpoint	NNS
cord-006229-7yoilsho	6572	29	for	for	IN
cord-006229-7yoilsho	6572	30	all	all	DT
cord-006229-7yoilsho	6572	31	of	of	IN
cord-006229-7yoilsho	6572	32	the	the	DT
cord-006229-7yoilsho	6572	33	analysed	analyse	VBN
cord-006229-7yoilsho	6572	34	fungicides	fungicide	NNS
cord-006229-7yoilsho	6572	35	or	or	CC
cord-006229-7yoilsho	6572	36	herbicides	herbicide	NNS
cord-006229-7yoilsho	6572	37	containing	contain	VBG
cord-006229-7yoilsho	6572	38	active	active	JJ
cord-006229-7yoilsho	6572	39	substances	substance	NNS
cord-006229-7yoilsho	6572	40	such	such	JJ
cord-006229-7yoilsho	6572	41	as	as	IN
cord-006229-7yoilsho	6572	42	epoxiconazole	epoxiconazole	NNP
cord-006229-7yoilsho	6572	43	,	,	,
cord-006229-7yoilsho	6572	44	cyproconazole	cyproconazole	NNP
cord-006229-7yoilsho	6572	45	,	,	,
cord-006229-7yoilsho	6572	46	azoxystrobin	azoxystrobin	NNP
cord-006229-7yoilsho	6572	47	or	or	CC
cord-006229-7yoilsho	6572	48	glyphosate	glyphosate	NNP
cord-006229-7yoilsho	6572	49	.	.	.
cord-006229-7yoilsho	6573	1	Chemical	chemical	NN
cord-006229-7yoilsho	6573	2	compounds	compound	NNS
cord-006229-7yoilsho	6573	3	may	may	MD
cord-006229-7yoilsho	6573	4	induce	induce	VB
cord-006229-7yoilsho	6573	5	skin	skin	NN
cord-006229-7yoilsho	6573	6	sensitization	sensitization	NN
cord-006229-7yoilsho	6573	7	in	in	IN
cord-006229-7yoilsho	6573	8	humans	human	NNS
cord-006229-7yoilsho	6573	9	,	,	,
cord-006229-7yoilsho	6573	10	resulting	result	VBG
cord-006229-7yoilsho	6573	11	in	in	IN
cord-006229-7yoilsho	6573	12	tolerance	tolerance	NN
cord-006229-7yoilsho	6573	13	or	or	CC
cord-006229-7yoilsho	6573	14	allergic	allergic	JJ
cord-006229-7yoilsho	6573	15	contact	contact	NN
cord-006229-7yoilsho	6573	16	dermatitis	dermatitis	NN
cord-006229-7yoilsho	6573	17	after	after	IN
cord-006229-7yoilsho	6573	18	repeated	repeat	VBN
cord-006229-7yoilsho	6573	19	exposure	exposure	NN
cord-006229-7yoilsho	6573	20	.	.	.
cord-006229-7yoilsho	6574	1	Mechanistically	Mechanistically	NNP
cord-006229-7yoilsho	6574	2	,	,	,
cord-006229-7yoilsho	6574	3	the	the	DT
cord-006229-7yoilsho	6574	4	activation	activation	NN
cord-006229-7yoilsho	6574	5	of	of	IN
cord-006229-7yoilsho	6574	6	dendritic	dendritic	JJ
cord-006229-7yoilsho	6574	7	cells	cell	NNS
cord-006229-7yoilsho	6574	8	is	be	VBZ
cord-006229-7yoilsho	6574	9	one	one	CD
cord-006229-7yoilsho	6574	10	of	of	IN
cord-006229-7yoilsho	6574	11	the	the	DT
cord-006229-7yoilsho	6574	12	prerequisites	prerequisite	NNS
cord-006229-7yoilsho	6574	13	for	for	IN
cord-006229-7yoilsho	6574	14	the	the	DT
cord-006229-7yoilsho	6574	15	induction	induction	NN
cord-006229-7yoilsho	6574	16	of	of	IN
cord-006229-7yoilsho	6574	17	skin	skin	NN
cord-006229-7yoilsho	6574	18	sensitization	sensitization	NN
cord-006229-7yoilsho	6574	19	.	.	.
cord-006229-7yoilsho	6575	1	A	a	DT
cord-006229-7yoilsho	6575	2	subgroup	subgroup	NN
cord-006229-7yoilsho	6575	3	of	of	IN
cord-006229-7yoilsho	6575	4	sensitizing	sensitize	VBG
cord-006229-7yoilsho	6575	5	chemicals	chemical	NNS
cord-006229-7yoilsho	6575	6	,	,	,
cord-006229-7yoilsho	6575	7	prohaptens	prohaptens	NNP
cord-006229-7yoilsho	6575	8	,	,	,
cord-006229-7yoilsho	6575	9	need	need	VB
cord-006229-7yoilsho	6575	10	metabolic	metabolic	JJ
cord-006229-7yoilsho	6575	11	activation	activation	NN
cord-006229-7yoilsho	6575	12	,	,	,
cord-006229-7yoilsho	6575	13	e.g.	e.g.	RB
cord-006229-7yoilsho	6575	14	via	via	IN
cord-006229-7yoilsho	6575	15	cytochrome	cytochrome	NN
cord-006229-7yoilsho	6575	16	P450	p450	NN
cord-006229-7yoilsho	6575	17	(	(	-LRB-
cord-006229-7yoilsho	6575	18	CYP	CYP	NNP
cord-006229-7yoilsho	6575	19	)	)	-RRB-
cord-006229-7yoilsho	6575	20	enzymes	enzyme	NNS
cord-006229-7yoilsho	6575	21	.	.	.
cord-006229-7yoilsho	6576	1	Thus	thus	RB
cord-006229-7yoilsho	6576	2	,	,	,
cord-006229-7yoilsho	6576	3	xenobiotic	xenobiotic	JJ
cord-006229-7yoilsho	6576	4	metabolism	metabolism	NN
cord-006229-7yoilsho	6576	5	may	may	MD
cord-006229-7yoilsho	6576	6	crucially	crucially	RB
cord-006229-7yoilsho	6576	7	impact	impact	VB
cord-006229-7yoilsho	6576	8	on	on	IN
cord-006229-7yoilsho	6576	9	a	a	DT
cord-006229-7yoilsho	6576	10	chemical	chemical	NN
cord-006229-7yoilsho	6576	11	's	's	POS
cord-006229-7yoilsho	6576	12	potential	potential	NN
cord-006229-7yoilsho	6576	13	for	for	IN
cord-006229-7yoilsho	6576	14	the	the	DT
cord-006229-7yoilsho	6576	15	induction	induction	NN
cord-006229-7yoilsho	6576	16	of	of	IN
cord-006229-7yoilsho	6576	17	skin	skin	NN
cord-006229-7yoilsho	6576	18	sensitization	sensitization	NN
cord-006229-7yoilsho	6576	19	by	by	IN
cord-006229-7yoilsho	6576	20	activation	activation	NN
cord-006229-7yoilsho	6576	21	,	,	,
cord-006229-7yoilsho	6576	22	but	but	CC
cord-006229-7yoilsho	6576	23	also	also	RB
cord-006229-7yoilsho	6576	24	deactivation	deactivation	NN
cord-006229-7yoilsho	6576	25	of	of	IN
cord-006229-7yoilsho	6576	26	reactive	reactive	JJ
cord-006229-7yoilsho	6576	27	molecules	molecule	NNS
cord-006229-7yoilsho	6576	28	via	via	IN
cord-006229-7yoilsho	6576	29	conjugation	conjugation	NN
cord-006229-7yoilsho	6576	30	,	,	,
cord-006229-7yoilsho	6576	31	which	which	WDT
cord-006229-7yoilsho	6576	32	determines	determine	VBZ
cord-006229-7yoilsho	6576	33	the	the	DT
cord-006229-7yoilsho	6576	34	concentration	concentration	NN
cord-006229-7yoilsho	6576	35	and	and	CC
cord-006229-7yoilsho	6576	36	the	the	DT
cord-006229-7yoilsho	6576	37	chemical	chemical	NN
cord-006229-7yoilsho	6576	38	species	specie	NNS
cord-006229-7yoilsho	6576	39	available	available	JJ
cord-006229-7yoilsho	6576	40	for	for	IN
cord-006229-7yoilsho	6576	41	protein	protein	NN
cord-006229-7yoilsho	6576	42	haptenation	haptenation	NN
cord-006229-7yoilsho	6576	43	and	and	CC
cord-006229-7yoilsho	6576	44	cell	cell	NN
cord-006229-7yoilsho	6576	45	activation	activation	NN
cord-006229-7yoilsho	6576	46	.	.	.
cord-006229-7yoilsho	6577	1	We	-PRON-	PRP
cord-006229-7yoilsho	6577	2	established	establish	VBD
cord-006229-7yoilsho	6577	3	a	a	DT
cord-006229-7yoilsho	6577	4	coculture	coculture	NN
cord-006229-7yoilsho	6577	5	model	model	NN
cord-006229-7yoilsho	6577	6	consisting	consist	VBG
cord-006229-7yoilsho	6577	7	of	of	IN
cord-006229-7yoilsho	6577	8	HaCaT	HaCaT	NNP
cord-006229-7yoilsho	6577	9	keratinocytes	keratinocyte	NNS
cord-006229-7yoilsho	6577	10	and	and	CC
cord-006229-7yoilsho	6577	11	THP-1	THP-1	NNP
cord-006229-7yoilsho	6577	12	as	as	IN
cord-006229-7yoilsho	6577	13	surrogate	surrogate	JJ
cord-006229-7yoilsho	6577	14	dendritic	dendritic	JJ
cord-006229-7yoilsho	6577	15	cells	cell	NNS
cord-006229-7yoilsho	6577	16	for	for	IN
cord-006229-7yoilsho	6577	17	the	the	DT
cord-006229-7yoilsho	6577	18	detection	detection	NN
cord-006229-7yoilsho	6577	19	of	of	IN
cord-006229-7yoilsho	6577	20	sensitizing	sensitize	VBG
cord-006229-7yoilsho	6577	21	chemicals	chemical	NNS
cord-006229-7yoilsho	6577	22	and	and	CC
cord-006229-7yoilsho	6577	23	found	find	VBD
cord-006229-7yoilsho	6577	24	enhanced	enhance	VBN
cord-006229-7yoilsho	6577	25	CYP1	CYP1	NNP
cord-006229-7yoilsho	6577	26	enzyme	enzyme	NN
cord-006229-7yoilsho	6577	27	activity	activity	NN
cord-006229-7yoilsho	6577	28	in	in	IN
cord-006229-7yoilsho	6577	29	HaCaT	HaCaT	NNP
cord-006229-7yoilsho	6577	30	cells	cell	NNS
cord-006229-7yoilsho	6577	31	exposed	expose	VBN
cord-006229-7yoilsho	6577	32	to	to	IN
cord-006229-7yoilsho	6577	33	benzo[a]pyrene	benzo[a]pyrene	NN
cord-006229-7yoilsho	6577	34	(	(	-LRB-
cord-006229-7yoilsho	6577	35	B[a]P	B[a]P	NNP
cord-006229-7yoilsho	6577	36	)	)	-RRB-
cord-006229-7yoilsho	6577	37	and	and	CC
cord-006229-7yoilsho	6577	38	eugenol	eugenol	NN
cord-006229-7yoilsho	6577	39	as	as	RB
cord-006229-7yoilsho	6577	40	well	well	RB
cord-006229-7yoilsho	6577	41	as	as	IN
cord-006229-7yoilsho	6577	42	clearly	clearly	RB
cord-006229-7yoilsho	6577	43	increased	increase	VBN
cord-006229-7yoilsho	6577	44	expression	expression	NN
cord-006229-7yoilsho	6577	45	of	of	IN
cord-006229-7yoilsho	6577	46	cell	cell	NN
cord-006229-7yoilsho	6577	47	surface	surface	NN
cord-006229-7yoilsho	6577	48	molecule	molecule	NN
cord-006229-7yoilsho	6577	49	CD86	CD86	NNP
cord-006229-7yoilsho	6577	50	on	on	IN
cord-006229-7yoilsho	6577	51	THP-1	THP-1	NNP
cord-006229-7yoilsho	6577	52	cells	cell	NNS
cord-006229-7yoilsho	6577	53	after	after	IN
cord-006229-7yoilsho	6577	54	incubation	incubation	NN
cord-006229-7yoilsho	6577	55	with	with	IN
cord-006229-7yoilsho	6577	56	these	these	DT
cord-006229-7yoilsho	6577	57	prohaptens	prohapten	NNS
cord-006229-7yoilsho	6577	58	(	(	-LRB-
cord-006229-7yoilsho	6577	59	Hennen	Hennen	NNP
cord-006229-7yoilsho	6577	60	et	et	FW
cord-006229-7yoilsho	6577	61	al	al	NNP
cord-006229-7yoilsho	6577	62	.	.	NNP
cord-006229-7yoilsho	6577	63	,	,	,
cord-006229-7yoilsho	6577	64	2011	2011	CD
cord-006229-7yoilsho	6577	65	)	)	-RRB-
cord-006229-7yoilsho	6577	66	.	.	.
cord-006229-7yoilsho	6578	1	Here	here	RB
cord-006229-7yoilsho	6578	2	,	,	,
cord-006229-7yoilsho	6578	3	we	-PRON-	PRP
cord-006229-7yoilsho	6578	4	studied	study	VBD
cord-006229-7yoilsho	6578	5	the	the	DT
cord-006229-7yoilsho	6578	6	impact	impact	NN
cord-006229-7yoilsho	6578	7	of	of	IN
cord-006229-7yoilsho	6578	8	intercellular	intercellular	JJ
cord-006229-7yoilsho	6578	9	cross	cross	NN
cord-006229-7yoilsho	6578	10	talk	talk	NN
cord-006229-7yoilsho	6578	11	on	on	IN
cord-006229-7yoilsho	6578	12	activation	activation	NN
cord-006229-7yoilsho	6578	13	and	and	CC
cord-006229-7yoilsho	6578	14	conjugation	conjugation	NN
cord-006229-7yoilsho	6578	15	capacities	capacity	NNS
cord-006229-7yoilsho	6578	16	in	in	IN
cord-006229-7yoilsho	6578	17	more	more	JJR
cord-006229-7yoilsho	6578	18	detail	detail	NN
cord-006229-7yoilsho	6578	19	.	.	.
cord-006229-7yoilsho	6579	1	Treatment	treatment	NN
cord-006229-7yoilsho	6579	2	of	of	IN
cord-006229-7yoilsho	6579	3	THP-1	THP-1	NNP
cord-006229-7yoilsho	6579	4	with	with	IN
cord-006229-7yoilsho	6579	5	B[a]P	B[a]P	.
cord-006229-7yoilsho	6579	6	and	and	CC
cord-006229-7yoilsho	6579	7	eugenol	eugenol	NN
cord-006229-7yoilsho	6579	8	in	in	IN
cord-006229-7yoilsho	6579	9	coculture	coculture	NN
cord-006229-7yoilsho	6579	10	with	with	IN
cord-006229-7yoilsho	6579	11	HaCaT	HaCaT	NNP
cord-006229-7yoilsho	6579	12	cells	cell	NNS
cord-006229-7yoilsho	6579	13	augmented	augment	VBN
cord-006229-7yoilsho	6579	14	CYP1A1	CYP1A1	NNP
cord-006229-7yoilsho	6579	15	and/or	and/or	CC
cord-006229-7yoilsho	6579	16	CYP1B1	CYP1B1	NNP
cord-006229-7yoilsho	6579	17	mRNA	mRNA	NNP
cord-006229-7yoilsho	6579	18	levels	level	NNS
cord-006229-7yoilsho	6579	19	,	,	,
cord-006229-7yoilsho	6579	20	while	while	IN
cord-006229-7yoilsho	6579	21	this	this	DT
cord-006229-7yoilsho	6579	22	was	be	VBD
cord-006229-7yoilsho	6579	23	not	not	RB
cord-006229-7yoilsho	6579	24	found	find	VBN
cord-006229-7yoilsho	6579	25	for	for	IN
cord-006229-7yoilsho	6579	26	THP-1	THP-1	NNP
cord-006229-7yoilsho	6579	27	monoculture	monoculture	NN
cord-006229-7yoilsho	6579	28	.	.	.
cord-006229-7yoilsho	6580	1	Augmentation	augmentation	NN
cord-006229-7yoilsho	6580	2	of	of	IN
cord-006229-7yoilsho	6580	3	CYP1A1	CYP1A1	NNP
cord-006229-7yoilsho	6580	4	mRNA	mrna	NN
cord-006229-7yoilsho	6580	5	needed	need	VBD
cord-006229-7yoilsho	6580	6	continuous	continuous	JJ
cord-006229-7yoilsho	6580	7	presence	presence	NN
cord-006229-7yoilsho	6580	8	of	of	IN
cord-006229-7yoilsho	6580	9	HaCaT	HaCaT	NNP
cord-006229-7yoilsho	6580	10	cells	cell	NNS
cord-006229-7yoilsho	6580	11	.	.	.
cord-006229-7yoilsho	6581	1	In	in	IN
cord-006229-7yoilsho	6581	2	coculture	coculture	NN
cord-006229-7yoilsho	6581	3	,	,	,
cord-006229-7yoilsho	6581	4	levels	level	NNS
cord-006229-7yoilsho	6581	5	of	of	IN
cord-006229-7yoilsho	6581	6	3-OH	3-oh	CD
cord-006229-7yoilsho	6581	7	-	-	:
cord-006229-7yoilsho	6581	8	B[a]P	B[a]P	NNP
cord-006229-7yoilsho	6581	9	as	as	IN
cord-006229-7yoilsho	6581	10	exemplary	exemplary	JJ
cord-006229-7yoilsho	6581	11	CYP	CYP	NNP
cord-006229-7yoilsho	6581	12	-	-	HYPH
cord-006229-7yoilsho	6581	13	dependent	dependent	JJ
cord-006229-7yoilsho	6581	14	metabolite	metabolite	NN
cord-006229-7yoilsho	6581	15	were	be	VBD
cord-006229-7yoilsho	6581	16	increased	increase	VBN
cord-006229-7yoilsho	6581	17	compared	compare	VBN
cord-006229-7yoilsho	6581	18	to	to	IN
cord-006229-7yoilsho	6581	19	single	single	JJ
cord-006229-7yoilsho	6581	20	cultures	culture	NNS
cord-006229-7yoilsho	6581	21	.	.	.
cord-006229-7yoilsho	6582	1	In	in	IN
cord-006229-7yoilsho	6582	2	contrast	contrast	NN
cord-006229-7yoilsho	6582	3	to	to	IN
cord-006229-7yoilsho	6582	4	this	this	DT
cord-006229-7yoilsho	6582	5	,	,	,
cord-006229-7yoilsho	6582	6	total	total	JJ
cord-006229-7yoilsho	6582	7	glutathione	glutathione	NN
cord-006229-7yoilsho	6582	8	contents	content	NNS
cord-006229-7yoilsho	6582	9	as	as	RB
cord-006229-7yoilsho	6582	10	well	well	RB
cord-006229-7yoilsho	6582	11	as	as	IN
cord-006229-7yoilsho	6582	12	N	n	CD
cord-006229-7yoilsho	6582	13	-	-	HYPH
cord-006229-7yoilsho	6582	14	acetyltransferase	acetyltransferase	NNP
cord-006229-7yoilsho	6582	15	1	1	CD
cord-006229-7yoilsho	6582	16	enzyme	enzyme	NN
cord-006229-7yoilsho	6582	17	activities	activity	NNS
cord-006229-7yoilsho	6582	18	in	in	IN
cord-006229-7yoilsho	6582	19	both	both	DT
cord-006229-7yoilsho	6582	20	cell	cell	NN
cord-006229-7yoilsho	6582	21	types	type	NNS
cord-006229-7yoilsho	6582	22	were	be	VBD
cord-006229-7yoilsho	6582	23	not	not	RB
cord-006229-7yoilsho	6582	24	modulated	modulate	VBN
cord-006229-7yoilsho	6582	25	in	in	IN
cord-006229-7yoilsho	6582	26	coculture	coculture	NN
cord-006229-7yoilsho	6582	27	,	,	,
cord-006229-7yoilsho	6582	28	furthermore	furthermore	RB
cord-006229-7yoilsho	6582	29	the	the	DT
cord-006229-7yoilsho	6582	30	capacity	capacity	NN
cord-006229-7yoilsho	6582	31	for	for	IN
cord-006229-7yoilsho	6582	32	sulfation	sulfation	NN
cord-006229-7yoilsho	6582	33	/	/	SYM
cord-006229-7yoilsho	6582	34	glucuronidation	glucuronidation	NN
cord-006229-7yoilsho	6582	35	of	of	IN
cord-006229-7yoilsho	6582	36	3-OH	3-oh	CD
cord-006229-7yoilsho	6582	37	-	-	:
cord-006229-7yoilsho	6582	38	B[a]P	B[a]P	NNP
cord-006229-7yoilsho	6582	39	was	be	VBD
cord-006229-7yoilsho	6582	40	maintained	maintain	VBN
cord-006229-7yoilsho	6582	41	in	in	IN
cord-006229-7yoilsho	6582	42	coculture	coculture	NN
cord-006229-7yoilsho	6582	43	.	.	.
cord-006229-7yoilsho	6583	1	Additionally	additionally	RB
cord-006229-7yoilsho	6583	2	,	,	,
cord-006229-7yoilsho	6583	3	the	the	DT
cord-006229-7yoilsho	6583	4	decrease	decrease	NN
cord-006229-7yoilsho	6583	5	of	of	IN
cord-006229-7yoilsho	6583	6	the	the	DT
cord-006229-7yoilsho	6583	7	total	total	JJ
cord-006229-7yoilsho	6583	8	glutathione	glutathione	NN
cord-006229-7yoilsho	6583	9	content	content	NN
cord-006229-7yoilsho	6583	10	in	in	IN
cord-006229-7yoilsho	6583	11	THP-1	THP-1	NNP
cord-006229-7yoilsho	6583	12	cells	cell	NNS
cord-006229-7yoilsho	6583	13	by	by	IN
cord-006229-7yoilsho	6583	14	2,4-dinitrochlorobenzene	2,4-dinitrochlorobenzene	CD
cord-006229-7yoilsho	6583	15	(	(	-LRB-
cord-006229-7yoilsho	6583	16	DNCB	DNCB	NNP
cord-006229-7yoilsho	6583	17	)	)	-RRB-
cord-006229-7yoilsho	6583	18	was	be	VBD
cord-006229-7yoilsho	6583	19	much	much	RB
cord-006229-7yoilsho	6583	20	less	less	RBR
cord-006229-7yoilsho	6583	21	pronounced	pronounce	VBN
cord-006229-7yoilsho	6583	22	when	when	WRB
cord-006229-7yoilsho	6583	23	exposed	expose	VBN
cord-006229-7yoilsho	6583	24	in	in	IN
cord-006229-7yoilsho	6583	25	coculture	coculture	NN
cord-006229-7yoilsho	6583	26	with	with	IN
cord-006229-7yoilsho	6583	27	HaCaT	HaCaT	NNP
cord-006229-7yoilsho	6583	28	cells	cell	NNS
cord-006229-7yoilsho	6583	29	,	,	,
cord-006229-7yoilsho	6583	30	showing	show	VBG
cord-006229-7yoilsho	6583	31	that	that	IN
cord-006229-7yoilsho	6583	32	HaCaT	HaCaT	NNP
cord-006229-7yoilsho	6583	33	cells	cell	NNS
cord-006229-7yoilsho	6583	34	provide	provide	VBP
cord-006229-7yoilsho	6583	35	additional	additional	JJ
cord-006229-7yoilsho	6583	36	targets	target	NNS
cord-006229-7yoilsho	6583	37	for	for	IN
cord-006229-7yoilsho	6583	38	cysteine	cysteine	NN
cord-006229-7yoilsho	6583	39	-	-	HYPH
cord-006229-7yoilsho	6583	40	reactive	reactive	JJ
cord-006229-7yoilsho	6583	41	chemicals	chemical	NNS
cord-006229-7yoilsho	6583	42	such	such	JJ
cord-006229-7yoilsho	6583	43	as	as	IN
cord-006229-7yoilsho	6583	44	DNCB	DNCB	NNP
cord-006229-7yoilsho	6583	45	,	,	,
cord-006229-7yoilsho	6583	46	diminishing	diminish	VBG
cord-006229-7yoilsho	6583	47	the	the	DT
cord-006229-7yoilsho	6583	48	total	total	JJ
cord-006229-7yoilsho	6583	49	amount	amount	NN
cord-006229-7yoilsho	6583	50	of	of	IN
cord-006229-7yoilsho	6583	51	chemicals	chemical	NNS
cord-006229-7yoilsho	6583	52	available	available	JJ
cord-006229-7yoilsho	6583	53	for	for	IN
cord-006229-7yoilsho	6583	54	THP-1	THP-1	NNP
cord-006229-7yoilsho	6583	55	cells	cell	NNS
cord-006229-7yoilsho	6583	56	.	.	.
cord-006229-7yoilsho	6584	1	Overall	overall	RB
cord-006229-7yoilsho	6584	2	,	,	,
cord-006229-7yoilsho	6584	3	results	result	NNS
cord-006229-7yoilsho	6584	4	indicate	indicate	VBP
cord-006229-7yoilsho	6584	5	that	that	IN
cord-006229-7yoilsho	6584	6	the	the	DT
cord-006229-7yoilsho	6584	7	cross	cross	NN
cord-006229-7yoilsho	6584	8	talk	talk	NN
cord-006229-7yoilsho	6584	9	between	between	IN
cord-006229-7yoilsho	6584	10	keratinocytes	keratinocyte	NNS
cord-006229-7yoilsho	6584	11	and	and	CC
cord-006229-7yoilsho	6584	12	antigenpresenting	antigenpresenting	NN
cord-006229-7yoilsho	6584	13	cells	cell	NNS
cord-006229-7yoilsho	6584	14	enhances	enhance	VBZ
cord-006229-7yoilsho	6584	15	their	-PRON-	PRP$
cord-006229-7yoilsho	6584	16	capacities	capacity	NNS
cord-006229-7yoilsho	6584	17	for	for	IN
cord-006229-7yoilsho	6584	18	metabolic	metabolic	JJ
cord-006229-7yoilsho	6584	19	activation	activation	NN
cord-006229-7yoilsho	6584	20	of	of	IN
cord-006229-7yoilsho	6584	21	chemicals	chemical	NNS
cord-006229-7yoilsho	6584	22	,	,	,
cord-006229-7yoilsho	6584	23	while	while	IN
cord-006229-7yoilsho	6584	24	HaCaT	HaCaT	NNP
cord-006229-7yoilsho	6584	25	cells	cell	NNS
cord-006229-7yoilsho	6584	26	also	also	RB
cord-006229-7yoilsho	6584	27	provide	provide	VBP
cord-006229-7yoilsho	6584	28	supplementary	supplementary	JJ
cord-006229-7yoilsho	6584	29	capacities	capacity	NNS
cord-006229-7yoilsho	6584	30	for	for	IN
cord-006229-7yoilsho	6584	31	phase	phase	NN
cord-006229-7yoilsho	6584	32	II	ii	CD
cord-006229-7yoilsho	6584	33	reactions	reaction	NNS
cord-006229-7yoilsho	6584	34	.	.	.
cord-006229-7yoilsho	6585	1	References	reference	NNS
cord-006229-7yoilsho	6585	2	:	:	:
cord-006229-7yoilsho	6586	1	Hennen	Hennen	NNP
cord-006229-7yoilsho	6586	2	J	J	NNP
cord-006229-7yoilsho	6586	3	et	et	NNP
cord-006229-7yoilsho	6586	4	al	al	NNP
cord-006229-7yoilsho	6586	5	.	.	.
cord-006229-7yoilsho	6587	1	Cross	cross	VB
cord-006229-7yoilsho	6587	2	talk	talk	NN
cord-006229-7yoilsho	6587	3	between	between	IN
cord-006229-7yoilsho	6587	4	keratinocytes	keratinocyte	NNS
cord-006229-7yoilsho	6587	5	and	and	CC
cord-006229-7yoilsho	6587	6	dendritic	dendritic	JJ
cord-006229-7yoilsho	6587	7	cells	cell	NNS
cord-006229-7yoilsho	6587	8	:	:	:
cord-006229-7yoilsho	6588	1	Impact	impact	NN
cord-006229-7yoilsho	6588	2	on	on	IN
cord-006229-7yoilsho	6588	3	the	the	DT
cord-006229-7yoilsho	6588	4	prediction	prediction	NN
cord-006229-7yoilsho	6588	5	of	of	IN
cord-006229-7yoilsho	6588	6	sen	sen	NNP
cord-006229-7yoilsho	6588	7	-	-	HYPH
cord-006229-7yoilsho	6588	8	sitization	sitization	NNP
cord-006229-7yoilsho	6588	9	.	.	.
cord-006229-7yoilsho	6589	1	Toxicol	Toxicol	NNP
cord-006229-7yoilsho	6589	2	Sci	Sci	NNP
cord-006229-7yoilsho	6589	3	2011	2011	CD
cord-006229-7yoilsho	6590	1	123:501	123:501	CD
cord-006229-7yoilsho	6590	2	-	-	HYPH
cord-006229-7yoilsho	6590	3	510.Toxicology	510.toxicology	CD
cord-006229-7yoilsho	6590	4	-Toxic	-toxic	RB
cord-006229-7yoilsho	6591	1	pathway	pathway	NNP
cord-006229-7yoilsho	6591	2	analysis	analysis	NNP
cord-006229-7yoilsho	6591	3	/	/	SYM
cord-006229-7yoilsho	6591	4	AOP	AOP	NNP
cord-006229-7yoilsho	6591	5	395	395	CD
cord-006229-7yoilsho	6591	6	Background	Background	NNP
cord-006229-7yoilsho	6591	7	:	:	:
cord-006229-7yoilsho	6592	1	Reticulated	reticulated	JJ
cord-006229-7yoilsho	6592	2	platelets	platelet	NNS
cord-006229-7yoilsho	6592	3	are	be	VBP
cord-006229-7yoilsho	6592	4	associated	associate	VBN
cord-006229-7yoilsho	6592	5	with	with	IN
cord-006229-7yoilsho	6592	6	impaired	impaired	JJ
cord-006229-7yoilsho	6592	7	antiplatelet	antiplatelet	NN
cord-006229-7yoilsho	6592	8	response	response	NN
cord-006229-7yoilsho	6592	9	to	to	IN
cord-006229-7yoilsho	6592	10	thienopyridine	thienopyridine	JJ
cord-006229-7yoilsho	6592	11	treatment	treatment	NN
cord-006229-7yoilsho	6592	12	.	.	.
cord-006229-7yoilsho	6593	1	This	this	DT
cord-006229-7yoilsho	6593	2	interaction	interaction	NN
cord-006229-7yoilsho	6593	3	might	may	MD
cord-006229-7yoilsho	6593	4	be	be	VB
cord-006229-7yoilsho	6593	5	caused	cause	VBN
cord-006229-7yoilsho	6593	6	by	by	IN
cord-006229-7yoilsho	6593	7	intrinsic	intrinsic	JJ
cord-006229-7yoilsho	6593	8	properties	property	NNS
cord-006229-7yoilsho	6593	9	of	of	IN
cord-006229-7yoilsho	6593	10	reticulated	reticulated	JJ
cord-006229-7yoilsho	6593	11	platelets	platelet	NNS
cord-006229-7yoilsho	6593	12	or	or	CC
cord-006229-7yoilsho	6593	13	a	a	DT
cord-006229-7yoilsho	6593	14	decreased	decrease	VBN
cord-006229-7yoilsho	6593	15	drug	drug	NN
cord-006229-7yoilsho	6593	16	exposure	exposure	NN
cord-006229-7yoilsho	6593	17	due	due	IN
cord-006229-7yoilsho	6593	18	to	to	IN
cord-006229-7yoilsho	6593	19	high	high	JJ
cord-006229-7yoilsho	6593	20	platelet	platelet	NN
cord-006229-7yoilsho	6593	21	turnover	turnover	NN
cord-006229-7yoilsho	6593	22	reflected	reflect	VBN
cord-006229-7yoilsho	6593	23	by	by	IN
cord-006229-7yoilsho	6593	24	reticulated	reticulated	JJ
cord-006229-7yoilsho	6593	25	platelets	platelet	NNS
cord-006229-7yoilsho	6593	26	as	as	IN
cord-006229-7yoilsho	6593	27	surrogate	surrogate	JJ
cord-006229-7yoilsho	6593	28	.	.	.
cord-006229-7yoilsho	6594	1	We	-PRON-	PRP
cord-006229-7yoilsho	6594	2	investigated	investigate	VBD
cord-006229-7yoilsho	6594	3	the	the	DT
cord-006229-7yoilsho	6594	4	impact	impact	NN
cord-006229-7yoilsho	6594	5	of	of	IN
cord-006229-7yoilsho	6594	6	reticulated	reticulated	JJ
cord-006229-7yoilsho	6594	7	platelets	platelet	NNS
cord-006229-7yoilsho	6594	8	on	on	IN
cord-006229-7yoilsho	6594	9	antiplatelet	antiplatelet	JJ
cord-006229-7yoilsho	6594	10	response	response	NN
cord-006229-7yoilsho	6594	11	to	to	IN
cord-006229-7yoilsho	6594	12	thienopyridines	thienopyridines	NNP
cord-006229-7yoilsho	6594	13	and	and	CC
cord-006229-7yoilsho	6594	14	if	if	IN
cord-006229-7yoilsho	6594	15	this	this	DT
cord-006229-7yoilsho	6594	16	effect	effect	NN
cord-006229-7yoilsho	6594	17	is	be	VBZ
cord-006229-7yoilsho	6594	18	linked	link	VBN
cord-006229-7yoilsho	6594	19	to	to	IN
cord-006229-7yoilsho	6594	20	platelet	platelet	NN
cord-006229-7yoilsho	6594	21	turnover	turnover	NN
cord-006229-7yoilsho	6594	22	.	.	.
cord-006229-7yoilsho	6595	1	Methods	method	NNS
cord-006229-7yoilsho	6595	2	:	:	:
cord-006229-7yoilsho	6596	1	This	this	DT
cord-006229-7yoilsho	6596	2	study	study	NN
cord-006229-7yoilsho	6596	3	randomized	randomize	VBD
cord-006229-7yoilsho	6596	4	elective	elective	JJ
cord-006229-7yoilsho	6596	5	patients	patient	NNS
cord-006229-7yoilsho	6596	6	to	to	IN
cord-006229-7yoilsho	6596	7	loading	load	VBG
cord-006229-7yoilsho	6596	8	with	with	IN
cord-006229-7yoilsho	6596	9	clopidogrel	clopidogrel	NNP
cord-006229-7yoilsho	6596	10	600	600	CD
cord-006229-7yoilsho	6596	11	mg	mg	NNP
cord-006229-7yoilsho	6596	12	or	or	CC
cord-006229-7yoilsho	6596	13	prasugrel	prasugrel	NNP
cord-006229-7yoilsho	6596	14	60	60	CD
cord-006229-7yoilsho	6596	15	mg	mg	NNP
cord-006229-7yoilsho	6596	16	(	(	-LRB-
cord-006229-7yoilsho	6596	17	n=200	n=200	NNP
cord-006229-7yoilsho	6596	18	)	)	-RRB-
cord-006229-7yoilsho	6596	19	.	.	.
cord-006229-7yoilsho	6597	1	ADP	ADP	NNP
cord-006229-7yoilsho	6597	2	-	-	HYPH
cord-006229-7yoilsho	6597	3	induced	induce	VBN
cord-006229-7yoilsho	6597	4	platelet	platelet	NN
cord-006229-7yoilsho	6597	5	reactivity	reactivity	NN
cord-006229-7yoilsho	6597	6	was	be	VBD
cord-006229-7yoilsho	6597	7	assessed	assess	VBN
cord-006229-7yoilsho	6597	8	by	by	IN
cord-006229-7yoilsho	6597	9	impedance	impedance	NN
cord-006229-7yoilsho	6597	10	aggregometry	aggregometry	NNP
cord-006229-7yoilsho	6597	11	30	30	CD
cord-006229-7yoilsho	6597	12	to	to	TO
cord-006229-7yoilsho	6597	13	120	120	CD
cord-006229-7yoilsho	6597	14	minutes	minute	NNS
cord-006229-7yoilsho	6597	15	and	and	CC
cord-006229-7yoilsho	6597	16	day	day	NN
cord-006229-7yoilsho	6597	17	1after	1after	CD
cord-006229-7yoilsho	6597	18	loading	loading	NN
cord-006229-7yoilsho	6597	19	but	but	CC
cord-006229-7yoilsho	6597	20	before	before	IN
cord-006229-7yoilsho	6597	21	intake	intake	NN
cord-006229-7yoilsho	6597	22	of	of	IN
cord-006229-7yoilsho	6597	23	the	the	DT
cord-006229-7yoilsho	6597	24	next	next	JJ
cord-006229-7yoilsho	6597	25	dose	dose	NN
cord-006229-7yoilsho	6597	26	of	of	IN
cord-006229-7yoilsho	6597	27	thienopyridines	thienopyridine	NNS
cord-006229-7yoilsho	6597	28	.	.	.
cord-006229-7yoilsho	6598	1	Immature	immature	JJ
cord-006229-7yoilsho	6598	2	platelet	platelet	NN
cord-006229-7yoilsho	6598	3	count	count	NN
cord-006229-7yoilsho	6598	4	(	(	-LRB-
cord-006229-7yoilsho	6598	5	IPC	IPC	NNP
cord-006229-7yoilsho	6598	6	)	)	-RRB-
cord-006229-7yoilsho	6598	7	was	be	VBD
cord-006229-7yoilsho	6598	8	assessed	assess	VBN
cord-006229-7yoilsho	6598	9	as	as	IN
cord-006229-7yoilsho	6598	10	marker	marker	NN
cord-006229-7yoilsho	6598	11	of	of	IN
cord-006229-7yoilsho	6598	12	reticulated	reticulated	JJ
cord-006229-7yoilsho	6598	13	platelets	platelet	NNS
cord-006229-7yoilsho	6598	14	by	by	IN
cord-006229-7yoilsho	6598	15	whole	whole	JJ
cord-006229-7yoilsho	6598	16	blood	blood	NN
cord-006229-7yoilsho	6598	17	flow	flow	NN
cord-006229-7yoilsho	6598	18	cytometry	cytometry	NN
cord-006229-7yoilsho	6598	19	.	.	.
cord-006229-7yoilsho	6599	1	Results	result	NNS
cord-006229-7yoilsho	6599	2	:	:	:
cord-006229-7yoilsho	6600	1	Platelet	platelet	NN
cord-006229-7yoilsho	6600	2	reactivity	reactivity	NN
cord-006229-7yoilsho	6600	3	increased	increase	VBD
cord-006229-7yoilsho	6600	4	with	with	IN
cord-006229-7yoilsho	6600	5	rising	rise	VBG
cord-006229-7yoilsho	6600	6	tertiles	tertile	NNS
cord-006229-7yoilsho	6600	7	of	of	IN
cord-006229-7yoilsho	6600	8	IPC	IPC	NNP
cord-006229-7yoilsho	6600	9	(	(	-LRB-
cord-006229-7yoilsho	6600	10	Figure	figure	NN
cord-006229-7yoilsho	6600	11	)	)	-RRB-
cord-006229-7yoilsho	6600	12	.	.	.
cord-006229-7yoilsho	6601	1	This	this	DT
cord-006229-7yoilsho	6601	2	effect	effect	NN
cord-006229-7yoilsho	6601	3	was	be	VBD
cord-006229-7yoilsho	6601	4	more	more	RBR
cord-006229-7yoilsho	6601	5	pronounced	pronounced	JJ
cord-006229-7yoilsho	6601	6	in	in	IN
cord-006229-7yoilsho	6601	7	patients	patient	NNS
cord-006229-7yoilsho	6601	8	on	on	IN
cord-006229-7yoilsho	6601	9	clopidogrel	clopidogrel	NN
cord-006229-7yoilsho	6601	10	as	as	IN
cord-006229-7yoilsho	6601	11	compared	compare	VBN
cord-006229-7yoilsho	6601	12	to	to	IN
cord-006229-7yoilsho	6601	13	patients	patient	NNS
cord-006229-7yoilsho	6601	14	on	on	IN
cord-006229-7yoilsho	6601	15	prasugrel	prasugrel	NNP
cord-006229-7yoilsho	6601	16	.	.	.
cord-006229-7yoilsho	6602	1	Overall	overall	RB
cord-006229-7yoilsho	6602	2	,	,	,
cord-006229-7yoilsho	6602	3	IPC	IPC	NNP
cord-006229-7yoilsho	6602	4	correlated	correlate	VBD
cord-006229-7yoilsho	6602	5	well	well	RB
cord-006229-7yoilsho	6602	6	with	with	IN
cord-006229-7yoilsho	6602	7	on	on	IN
cord-006229-7yoilsho	6602	8	-	-	HYPH
cord-006229-7yoilsho	6602	9	treatment	treatment	NN
cord-006229-7yoilsho	6602	10	platelet	platelet	NN
cord-006229-7yoilsho	6602	11	reactivity	reactivity	NN
cord-006229-7yoilsho	6602	12	at	at	IN
cord-006229-7yoilsho	6602	13	120min	120min	NNP
cord-006229-7yoilsho	6602	14	(	(	-LRB-
cord-006229-7yoilsho	6602	15	r=0.21	r=0.21	NNS
cord-006229-7yoilsho	6602	16	;	;	:
cord-006229-7yoilsho	6602	17	p<0.001	p<0.001	CD
cord-006229-7yoilsho	6602	18	)	)	-RRB-
cord-006229-7yoilsho	6602	19	.	.	.
cord-006229-7yoilsho	6603	1	This	this	DT
cord-006229-7yoilsho	6603	2	correlation	correlation	NN
cord-006229-7yoilsho	6603	3	did	do	VBD
cord-006229-7yoilsho	6603	4	not	not	RB
cord-006229-7yoilsho	6603	5	change	change	VB
cord-006229-7yoilsho	6603	6	over	over	IN
cord-006229-7yoilsho	6603	7	time	time	NN
cord-006229-7yoilsho	6603	8	indicating	indicate	VBG
cord-006229-7yoilsho	6603	9	an	an	DT
cord-006229-7yoilsho	6603	10	effect	effect	NN
cord-006229-7yoilsho	6603	11	independent	independent	JJ
cord-006229-7yoilsho	6603	12	of	of	IN
cord-006229-7yoilsho	6603	13	platelet	platelet	NN
cord-006229-7yoilsho	6603	14	turnover	turnover	NN
cord-006229-7yoilsho	6603	15	(	(	-LRB-
cord-006229-7yoilsho	6603	16	comparison	comparison	NN
cord-006229-7yoilsho	6603	17	of	of	IN
cord-006229-7yoilsho	6603	18	correlations	correlation	NNS
cord-006229-7yoilsho	6603	19	120min	120min	CD
cord-006229-7yoilsho	6603	20	/	/	SYM
cord-006229-7yoilsho	6603	21	day	day	NN
cord-006229-7yoilsho	6603	22	1	1	CD
cord-006229-7yoilsho	6603	23	:	:	:
cord-006229-7yoilsho	6603	24	p=0.57	p=0.57	VB
cord-006229-7yoilsho	6603	25	for	for	IN
cord-006229-7yoilsho	6603	26	clopidogrel	clopidogrel	NN
cord-006229-7yoilsho	6603	27	,	,	,
cord-006229-7yoilsho	6603	28	p=0.76	p=0.76	NNP
cord-006229-7yoilsho	6603	29	for	for	IN
cord-006229-7yoilsho	6603	30	prasugrel	prasugrel	NNP
cord-006229-7yoilsho	6603	31	)	)	-RRB-
cord-006229-7yoilsho	6603	32	.	.	.
cord-006229-7yoilsho	6604	1	Conclusion	conclusion	NN
cord-006229-7yoilsho	6604	2	:	:	:
cord-006229-7yoilsho	6605	1	A	a	DT
cord-006229-7yoilsho	6605	2	high	high	JJ
cord-006229-7yoilsho	6605	3	immature	immature	JJ
cord-006229-7yoilsho	6605	4	platelet	platelet	NN
cord-006229-7yoilsho	6605	5	count	count	NN
cord-006229-7yoilsho	6605	6	is	be	VBZ
cord-006229-7yoilsho	6605	7	associated	associate	VBN
cord-006229-7yoilsho	6605	8	with	with	IN
cord-006229-7yoilsho	6605	9	impaired	impaired	JJ
cord-006229-7yoilsho	6605	10	response	response	NN
cord-006229-7yoilsho	6605	11	to	to	IN
cord-006229-7yoilsho	6605	12	thienopyridine	thienopyridine	NNP
cord-006229-7yoilsho	6605	13	loading	loading	NN
cord-006229-7yoilsho	6605	14	.	.	.
cord-006229-7yoilsho	6606	1	This	this	DT
cord-006229-7yoilsho	6606	2	effect	effect	NN
cord-006229-7yoilsho	6606	3	is	be	VBZ
cord-006229-7yoilsho	6606	4	independent	independent	JJ
cord-006229-7yoilsho	6606	5	of	of	IN
cord-006229-7yoilsho	6606	6	platelet	platelet	NN
cord-006229-7yoilsho	6606	7	turnover	turnover	NN
cord-006229-7yoilsho	6606	8	indicating	indicate	VBG
cord-006229-7yoilsho	6606	9	a	a	DT
cord-006229-7yoilsho	6606	10	relation	relation	NN
cord-006229-7yoilsho	6606	11	to	to	IN
cord-006229-7yoilsho	6606	12	intrinsic	intrinsic	JJ
cord-006229-7yoilsho	6606	13	properties	property	NNS
cord-006229-7yoilsho	6606	14	of	of	IN
cord-006229-7yoilsho	6606	15	reticulated	reticulated	JJ
cord-006229-7yoilsho	6606	16	platelets	platelet	NNS
cord-006229-7yoilsho	6606	17	.	.	.
cord-006229-7yoilsho	6607	1	Introduction	introduction	NN
cord-006229-7yoilsho	6607	2	:	:	:
cord-006229-7yoilsho	6608	1	One	one	CD
cord-006229-7yoilsho	6608	2	of	of	IN
cord-006229-7yoilsho	6608	3	the	the	DT
cord-006229-7yoilsho	6608	4	biggest	big	JJS
cord-006229-7yoilsho	6608	5	drawbacks	drawback	NNS
cord-006229-7yoilsho	6608	6	of	of	IN
cord-006229-7yoilsho	6608	7	protein	protein	NN
cord-006229-7yoilsho	6608	8	-	-	HYPH
cord-006229-7yoilsho	6608	9	based	base	VBN
cord-006229-7yoilsho	6608	10	therapeutics	therapeutic	NNS
cord-006229-7yoilsho	6608	11	with	with	IN
cord-006229-7yoilsho	6608	12	intracellular	intracellular	JJ
cord-006229-7yoilsho	6608	13	targets	target	NNS
cord-006229-7yoilsho	6608	14	is	be	VBZ
cord-006229-7yoilsho	6608	15	their	-PRON-	PRP$
cord-006229-7yoilsho	6608	16	inability	inability	NN
cord-006229-7yoilsho	6608	17	to	to	TO
cord-006229-7yoilsho	6608	18	enter	enter	VB
cord-006229-7yoilsho	6608	19	the	the	DT
cord-006229-7yoilsho	6608	20	cytosol	cytosol	NN
cord-006229-7yoilsho	6608	21	.	.	.
cord-006229-7yoilsho	6609	1	Targeted	target	VBN
cord-006229-7yoilsho	6609	2	toxins	toxin	NNS
cord-006229-7yoilsho	6609	3	are	be	VBP
cord-006229-7yoilsho	6609	4	known	know	VBN
cord-006229-7yoilsho	6609	5	to	to	TO
cord-006229-7yoilsho	6609	6	be	be	VB
cord-006229-7yoilsho	6609	7	used	use	VBN
cord-006229-7yoilsho	6609	8	in	in	IN
cord-006229-7yoilsho	6609	9	drug	drug	NN
cord-006229-7yoilsho	6609	10	delivery	delivery	NN
cord-006229-7yoilsho	6609	11	.	.	.
cord-006229-7yoilsho	6610	1	Aim	Aim	NNP
cord-006229-7yoilsho	6610	2	of	of	IN
cord-006229-7yoilsho	6610	3	the	the	DT
cord-006229-7yoilsho	6610	4	study	study	NN
cord-006229-7yoilsho	6610	5	was	be	VBD
cord-006229-7yoilsho	6610	6	to	to	TO
cord-006229-7yoilsho	6610	7	target	target	VB
cord-006229-7yoilsho	6610	8	epidermal	epidermal	JJ
cord-006229-7yoilsho	6610	9	growth	growth	NN
cord-006229-7yoilsho	6610	10	factor	factor	NN
cord-006229-7yoilsho	6610	11	(	(	-LRB-
cord-006229-7yoilsho	6610	12	EGF	EGF	NNP
cord-006229-7yoilsho	6610	13	)	)	-RRB-
cord-006229-7yoilsho	6610	14	receptor	receptor	NN
cord-006229-7yoilsho	6610	15	overexpressed	overexpresse	VBN
cord-006229-7yoilsho	6610	16	on	on	IN
cord-006229-7yoilsho	6610	17	pancreatic	pancreatic	JJ
cord-006229-7yoilsho	6610	18	carcinoma	carcinoma	NN
cord-006229-7yoilsho	6610	19	using	use	VBG
cord-006229-7yoilsho	6610	20	a	a	DT
cord-006229-7yoilsho	6610	21	novel	novel	JJ
cord-006229-7yoilsho	6610	22	well	well	RB
cord-006229-7yoilsho	6610	23	-	-	HYPH
cord-006229-7yoilsho	6610	24	defined	define	VBN
cord-006229-7yoilsho	6610	25	targeted	target	VBN
cord-006229-7yoilsho	6610	26	toxin	toxin	NN
cord-006229-7yoilsho	6610	27	consisting	consist	VBG
cord-006229-7yoilsho	6610	28	of	of	IN
cord-006229-7yoilsho	6610	29	EGF	EGF	NNP
cord-006229-7yoilsho	6610	30	fused	fuse	VBN
cord-006229-7yoilsho	6610	31	to	to	IN
cord-006229-7yoilsho	6610	32	the	the	DT
cord-006229-7yoilsho	6610	33	toxic	toxic	JJ
cord-006229-7yoilsho	6610	34	plant	plant	NN
cord-006229-7yoilsho	6610	35	ribosome	ribosome	NN
cord-006229-7yoilsho	6610	36	-	-	HYPH
cord-006229-7yoilsho	6610	37	inactivating	inactivate	VBG
cord-006229-7yoilsho	6610	38	protein	protein	NN
cord-006229-7yoilsho	6610	39	dianthin	dianthin	NNP
cord-006229-7yoilsho	6610	40	and	and	CC
cord-006229-7yoilsho	6610	41	a	a	DT
cord-006229-7yoilsho	6610	42	glycosidic	glycosidic	JJ
cord-006229-7yoilsho	6610	43	triterpenoid	triterpenoid	NN
cord-006229-7yoilsho	6610	44	(	(	-LRB-
cord-006229-7yoilsho	6610	45	SO1861	so1861	NN
cord-006229-7yoilsho	6610	46	)	)	-RRB-
cord-006229-7yoilsho	6610	47	as	as	IN
cord-006229-7yoilsho	6610	48	efficacy	efficacy	NN
cord-006229-7yoilsho	6610	49	enhancer	enhancer	NN
cord-006229-7yoilsho	6610	50	.	.	.
cord-006229-7yoilsho	6611	1	Methods	method	NNS
cord-006229-7yoilsho	6611	2	:	:	:
cord-006229-7yoilsho	6612	1	The	the	DT
cord-006229-7yoilsho	6612	2	enzymatic	enzymatic	JJ
cord-006229-7yoilsho	6612	3	activity	activity	NN
cord-006229-7yoilsho	6612	4	of	of	IN
cord-006229-7yoilsho	6612	5	dianthin	dianthin	NN
cord-006229-7yoilsho	6612	6	-	-	HYPH
cord-006229-7yoilsho	6612	7	EGF	EGF	NNP
cord-006229-7yoilsho	6612	8	was	be	VBD
cord-006229-7yoilsho	6612	9	verified	verify	VBN
cord-006229-7yoilsho	6612	10	by	by	IN
cord-006229-7yoilsho	6612	11	an	an	DT
cord-006229-7yoilsho	6612	12	adenine	adenine	NN
cord-006229-7yoilsho	6612	13	release	release	NN
cord-006229-7yoilsho	6612	14	assay	assay	NN
cord-006229-7yoilsho	6612	15	.	.	.
cord-006229-7yoilsho	6613	1	The	the	DT
cord-006229-7yoilsho	6613	2	kinetics	kinetic	NNS
cord-006229-7yoilsho	6613	3	of	of	IN
cord-006229-7yoilsho	6613	4	cytotoxicity	cytotoxicity	NN
cord-006229-7yoilsho	6613	5	were	be	VBD
cord-006229-7yoilsho	6613	6	evaluated	evaluate	VBN
cord-006229-7yoilsho	6613	7	in	in	IN
cord-006229-7yoilsho	6613	8	pancreatic	pancreatic	JJ
cord-006229-7yoilsho	6613	9	adenocarcinoma	adenocarcinoma	NN
cord-006229-7yoilsho	6613	10	BxPC-3	BxPC-3	NNP
cord-006229-7yoilsho	6613	11	and	and	CC
cord-006229-7yoilsho	6613	12	MIAPaCa-2	MIAPaCa-2	NNP
cord-006229-7yoilsho	6613	13	cells	cell	NNS
cord-006229-7yoilsho	6613	14	in	in	IN
cord-006229-7yoilsho	6613	15	comparison	comparison	NN
cord-006229-7yoilsho	6613	16	to	to	IN
cord-006229-7yoilsho	6613	17	the	the	DT
cord-006229-7yoilsho	6613	18	non	non	JJ
cord-006229-7yoilsho	6613	19	-	-	JJ
cord-006229-7yoilsho	6613	20	target	target	JJ
cord-006229-7yoilsho	6613	21	cell	cell	NN
cord-006229-7yoilsho	6613	22	line	line	NN
cord-006229-7yoilsho	6613	23	NIH3T3	NIH3T3	NNP
cord-006229-7yoilsho	6613	24	with	with	IN
cord-006229-7yoilsho	6613	25	an	an	DT
cord-006229-7yoilsho	6613	26	impedance	impedance	NN
cord-006229-7yoilsho	6613	27	-	-	HYPH
cord-006229-7yoilsho	6613	28	based	base	VBN
cord-006229-7yoilsho	6613	29	real	real	JJ
cord-006229-7yoilsho	6613	30	time	time	NN
cord-006229-7yoilsho	6613	31	cell	cell	NN
cord-006229-7yoilsho	6613	32	analyzer	analyzer	NN
cord-006229-7yoilsho	6613	33	(	(	-LRB-
cord-006229-7yoilsho	6613	34	xCELLigence	xcelligence	NN
cord-006229-7yoilsho	6613	35	)	)	-RRB-
cord-006229-7yoilsho	6613	36	and	and	CC
cord-006229-7yoilsho	6613	37	final	final	JJ
cord-006229-7yoilsho	6613	38	cytotoxicity	cytotoxicity	NN
cord-006229-7yoilsho	6613	39	analyses	analysis	NNS
cord-006229-7yoilsho	6613	40	with	with	IN
cord-006229-7yoilsho	6613	41	conventional	conventional	JJ
cord-006229-7yoilsho	6613	42	end	end	NN
cord-006229-7yoilsho	6613	43	-	-	HYPH
cord-006229-7yoilsho	6613	44	point	point	NN
cord-006229-7yoilsho	6613	45	MTT	MTT	NNP
cord-006229-7yoilsho	6613	46	assays	assay	NNS
cord-006229-7yoilsho	6613	47	.	.	.
cord-006229-7yoilsho	6614	1	Acute	acute	JJ
cord-006229-7yoilsho	6614	2	toxic	toxic	JJ
cord-006229-7yoilsho	6614	3	of	of	IN
cord-006229-7yoilsho	6614	4	dianthin	dianthin	NN
cord-006229-7yoilsho	6614	5	-	-	HYPH
cord-006229-7yoilsho	6614	6	EGF	EGF	NNP
cord-006229-7yoilsho	6614	7	was	be	VBD
cord-006229-7yoilsho	6614	8	studied	study	VBN
cord-006229-7yoilsho	6614	9	in	in	IN
cord-006229-7yoilsho	6614	10	male	male	JJ
cord-006229-7yoilsho	6614	11	BALB	BALB	NNP
cord-006229-7yoilsho	6614	12	/	/	SYM
cord-006229-7yoilsho	6614	13	c	c	NN
cord-006229-7yoilsho	6614	14	mice	mouse	NNS
cord-006229-7yoilsho	6614	15	.	.	.
cord-006229-7yoilsho	6615	1	A	a	DT
cord-006229-7yoilsho	6615	2	xenograft	xenograft	NN
cord-006229-7yoilsho	6615	3	solid	solid	JJ
cord-006229-7yoilsho	6615	4	tumor	tumor	NN
cord-006229-7yoilsho	6615	5	model	model	NN
cord-006229-7yoilsho	6615	6	was	be	VBD
cord-006229-7yoilsho	6615	7	developed	develop	VBN
cord-006229-7yoilsho	6615	8	in	in	IN
cord-006229-7yoilsho	6615	9	male	male	JJ
cord-006229-7yoilsho	6615	10	nude	nude	JJ
cord-006229-7yoilsho	6615	11	mice	mouse	NNS
cord-006229-7yoilsho	6615	12	by	by	IN
cord-006229-7yoilsho	6615	13	injecting	inject	VBG
cord-006229-7yoilsho	6615	14	BxPC-3	BxPC-3	NNP
cord-006229-7yoilsho	6615	15	cells	cell	NNS
cord-006229-7yoilsho	6615	16	into	into	IN
cord-006229-7yoilsho	6615	17	the	the	DT
cord-006229-7yoilsho	6615	18	dorsal	dorsal	JJ
cord-006229-7yoilsho	6615	19	part	part	NN
cord-006229-7yoilsho	6615	20	subcutaneously	subcutaneously	RB
cord-006229-7yoilsho	6615	21	.	.	.
cord-006229-7yoilsho	6616	1	Dianthin	Dianthin	NNP
cord-006229-7yoilsho	6616	2	-	-	HYPH
cord-006229-7yoilsho	6616	3	EGF	EGF	NNP
cord-006229-7yoilsho	6616	4	was	be	VBD
cord-006229-7yoilsho	6616	5	administered	administer	VBN
cord-006229-7yoilsho	6616	6	at	at	IN
cord-006229-7yoilsho	6616	7	the	the	DT
cord-006229-7yoilsho	6616	8	vicinity	vicinity	NN
cord-006229-7yoilsho	6616	9	of	of	IN
cord-006229-7yoilsho	6616	10	the	the	DT
cord-006229-7yoilsho	6616	11	tumor	tumor	NN
cord-006229-7yoilsho	6616	12	and	and	CC
cord-006229-7yoilsho	6616	13	SO1861	SO1861	NNS
cord-006229-7yoilsho	6616	14	by	by	IN
cord-006229-7yoilsho	6616	15	subcutaneous	subcutaneous	JJ
cord-006229-7yoilsho	6616	16	injection	injection	NN
cord-006229-7yoilsho	6616	17	at	at	IN
cord-006229-7yoilsho	6616	18	the	the	DT
cord-006229-7yoilsho	6616	19	neck	neck	NN
cord-006229-7yoilsho	6616	20	.	.	.
cord-006229-7yoilsho	6617	1	After	after	IN
cord-006229-7yoilsho	6617	2	the	the	DT
cord-006229-7yoilsho	6617	3	tumor	tumor	NN
cord-006229-7yoilsho	6617	4	reached	reach	VBD
cord-006229-7yoilsho	6617	5	a	a	DT
cord-006229-7yoilsho	6617	6	diameter	diameter	NN
cord-006229-7yoilsho	6617	7	of	of	IN
cord-006229-7yoilsho	6617	8	2	2	CD
cord-006229-7yoilsho	6617	9	to	to	TO
cord-006229-7yoilsho	6617	10	3	3	CD
cord-006229-7yoilsho	6617	11	mm	mm	NN
cord-006229-7yoilsho	6617	12	in	in	IN
cord-006229-7yoilsho	6617	13	size	size	NN
cord-006229-7yoilsho	6617	14	6	6	CD
cord-006229-7yoilsho	6617	15	treatments	treatment	NNS
cord-006229-7yoilsho	6617	16	were	be	VBD
cord-006229-7yoilsho	6617	17	given	give	VBN
cord-006229-7yoilsho	6617	18	in	in	IN
cord-006229-7yoilsho	6617	19	total	total	NN
cord-006229-7yoilsho	6617	20	.	.	.
cord-006229-7yoilsho	6618	1	Tumor	tumor	NN
cord-006229-7yoilsho	6618	2	volumes	volume	NNS
cord-006229-7yoilsho	6618	3	and	and	CC
cord-006229-7yoilsho	6618	4	body	body	NN
cord-006229-7yoilsho	6618	5	weight	weight	NN
cord-006229-7yoilsho	6618	6	shifts	shift	NNS
cord-006229-7yoilsho	6618	7	were	be	VBD
cord-006229-7yoilsho	6618	8	observed	observe	VBN
cord-006229-7yoilsho	6618	9	twice	twice	RB
cord-006229-7yoilsho	6618	10	weekly	weekly	RB
cord-006229-7yoilsho	6618	11	to	to	TO
cord-006229-7yoilsho	6618	12	determine	determine	VB
cord-006229-7yoilsho	6618	13	the	the	DT
cord-006229-7yoilsho	6618	14	potency	potency	NN
cord-006229-7yoilsho	6618	15	of	of	IN
cord-006229-7yoilsho	6618	16	dianthin	dianthin	NNP
cord-006229-7yoilsho	6618	17	-	-	HYPH
cord-006229-7yoilsho	6618	18	EGF	EGF	NNP
cord-006229-7yoilsho	6618	19	when	when	WRB
cord-006229-7yoilsho	6618	20	given	give	VBN
cord-006229-7yoilsho	6618	21	alone	alone	JJ
cord-006229-7yoilsho	6618	22	and	and	CC
cord-006229-7yoilsho	6618	23	in	in	IN
cord-006229-7yoilsho	6618	24	combination	combination	NN
cord-006229-7yoilsho	6618	25	with	with	IN
cord-006229-7yoilsho	6618	26	SO1861	SO1861	NNS
cord-006229-7yoilsho	6618	27	in	in	IN
cord-006229-7yoilsho	6618	28	comparison	comparison	NN
cord-006229-7yoilsho	6618	29	to	to	IN
cord-006229-7yoilsho	6618	30	placebo	placebo	NN
cord-006229-7yoilsho	6618	31	.	.	.
cord-006229-7yoilsho	6619	1	Immunohistochemical	immunohistochemical	JJ
cord-006229-7yoilsho	6619	2	detection	detection	NN
cord-006229-7yoilsho	6619	3	of	of	IN
cord-006229-7yoilsho	6619	4	EGF	EGF	NNP
cord-006229-7yoilsho	6619	5	receptor	receptor	NN
cord-006229-7yoilsho	6619	6	was	be	VBD
cord-006229-7yoilsho	6619	7	performed	perform	VBN
cord-006229-7yoilsho	6619	8	according	accord	VBG
cord-006229-7yoilsho	6619	9	to	to	IN
cord-006229-7yoilsho	6619	10	the	the	DT
cord-006229-7yoilsho	6619	11	manufacturers	manufacturer	NNS
cord-006229-7yoilsho	6619	12	's	's	POS
cord-006229-7yoilsho	6619	13	advice	advice	NN
cord-006229-7yoilsho	6619	14	(	(	-LRB-
cord-006229-7yoilsho	6619	15	DAKO	DAKO	NNP
cord-006229-7yoilsho	6619	16	,	,	,
cord-006229-7yoilsho	6619	17	Glostrup	Glostrup	NNP
cord-006229-7yoilsho	6619	18	,	,	,
cord-006229-7yoilsho	6619	19	Denmark	Denmark	NNP
cord-006229-7yoilsho	6619	20	,	,	,
cord-006229-7yoilsho	6619	21	K1492	K1492	NNP
cord-006229-7yoilsho	6619	22	)	)	-RRB-
cord-006229-7yoilsho	6619	23	.	.	.
cord-006229-7yoilsho	6620	1	Complete	complete	JJ
cord-006229-7yoilsho	6620	2	blood	blood	NN
cord-006229-7yoilsho	6620	3	count	count	NN
cord-006229-7yoilsho	6620	4	analysis	analysis	NN
cord-006229-7yoilsho	6620	5	was	be	VBD
cord-006229-7yoilsho	6620	6	done	do	VBN
cord-006229-7yoilsho	6620	7	by	by	IN
cord-006229-7yoilsho	6620	8	Labor	Labor	NNP
cord-006229-7yoilsho	6620	9	28	28	CD
cord-006229-7yoilsho	6620	10	GmbH	GmbH	NNP
cord-006229-7yoilsho	6620	11	,	,	,
cord-006229-7yoilsho	6620	12	Berlin	Berlin	NNP
cord-006229-7yoilsho	6620	13	.	.	.
cord-006229-7yoilsho	6621	1	Results	result	NNS
cord-006229-7yoilsho	6621	2	:	:	:
cord-006229-7yoilsho	6622	1	The	the	DT
cord-006229-7yoilsho	6622	2	adenine	adenine	NN
cord-006229-7yoilsho	6622	3	release	release	NN
cord-006229-7yoilsho	6622	4	mediated	mediate	VBN
cord-006229-7yoilsho	6622	5	by	by	IN
cord-006229-7yoilsho	6622	6	dianthin	dianthin	NNP
cord-006229-7yoilsho	6622	7	-	-	HYPH
cord-006229-7yoilsho	6622	8	EGF	EGF	NNP
cord-006229-7yoilsho	6622	9	was	be	VBD
cord-006229-7yoilsho	6622	10	47.8	47.8	CD
cord-006229-7yoilsho	6622	11	pmol	pmol	JJ
cord-006229-7yoilsho	6622	12	adenine	adenine	NN
cord-006229-7yoilsho	6622	13	/	/	SYM
cord-006229-7yoilsho	6622	14	pmol	pmol	JJ
cord-006229-7yoilsho	6622	15	toxin	toxin	NN
cord-006229-7yoilsho	6622	16	/	/	SYM
cord-006229-7yoilsho	6622	17	h	h	NN
cord-006229-7yoilsho	6622	18	.	.	.
cord-006229-7yoilsho	6623	1	The	the	DT
cord-006229-7yoilsho	6623	2	in	in	FW
cord-006229-7yoilsho	6623	3	vitro	vitro	FW
cord-006229-7yoilsho	6623	4	efficacy	efficacy	NN
cord-006229-7yoilsho	6623	5	of	of	IN
cord-006229-7yoilsho	6623	6	the	the	DT
cord-006229-7yoilsho	6623	7	targeted	target	VBN
cord-006229-7yoilsho	6623	8	toxin	toxin	NN
cord-006229-7yoilsho	6623	9	was	be	VBD
cord-006229-7yoilsho	6623	10	proven	prove	VBN
cord-006229-7yoilsho	6623	11	by	by	IN
cord-006229-7yoilsho	6623	12	an	an	DT
cord-006229-7yoilsho	6623	13	IC50	IC50	NNP
cord-006229-7yoilsho	6623	14	value	value	NN
cord-006229-7yoilsho	6623	15	of	of	IN
cord-006229-7yoilsho	6623	16	approximately	approximately	RB
cord-006229-7yoilsho	6623	17	1	1	CD
cord-006229-7yoilsho	6623	18	nM	nm	NN
cord-006229-7yoilsho	6623	19	for	for	IN
cord-006229-7yoilsho	6623	20	EGF	EGF	NNP
cord-006229-7yoilsho	6623	21	receptor	receptor	NN
cord-006229-7yoilsho	6623	22	expressing	express	VBG
cord-006229-7yoilsho	6623	23	MIAPaCa-2	MIAPaCa-2	NNPS
cord-006229-7yoilsho	6623	24	and	and	CC
cord-006229-7yoilsho	6623	25	BxPC-3	BxPC-3	NNP
cord-006229-7yoilsho	6623	26	cells	cell	NNS
cord-006229-7yoilsho	6623	27	as	as	IN
cord-006229-7yoilsho	6623	28	compared	compare	VBN
cord-006229-7yoilsho	6623	29	to	to	IN
cord-006229-7yoilsho	6623	30	100	100	CD
cord-006229-7yoilsho	6623	31	nM	nm	NN
cord-006229-7yoilsho	6623	32	for	for	IN
cord-006229-7yoilsho	6623	33	non	non	JJ
cord-006229-7yoilsho	6623	34	-	-	JJ
cord-006229-7yoilsho	6623	35	target	target	JJ
cord-006229-7yoilsho	6623	36	NIH3T3	NIH3T3	NNP
cord-006229-7yoilsho	6623	37	cells	cell	NNS
cord-006229-7yoilsho	6623	38	.	.	.
cord-006229-7yoilsho	6624	1	Real	real	JJ
cord-006229-7yoilsho	6624	2	time	time	NN
cord-006229-7yoilsho	6624	3	measurement	measurement	NN
cord-006229-7yoilsho	6624	4	of	of	IN
cord-006229-7yoilsho	6624	5	the	the	DT
cord-006229-7yoilsho	6624	6	cytotoxicity	cytotoxicity	NN
cord-006229-7yoilsho	6624	7	showed	show	VBD
cord-006229-7yoilsho	6624	8	a	a	DT
cord-006229-7yoilsho	6624	9	dose	dose	NN
cord-006229-7yoilsho	6624	10	-	-	HYPH
cord-006229-7yoilsho	6624	11	dependent	dependent	JJ
cord-006229-7yoilsho	6624	12	decrease	decrease	NN
cord-006229-7yoilsho	6624	13	in	in	IN
cord-006229-7yoilsho	6624	14	cell	cell	NN
cord-006229-7yoilsho	6624	15	viability	viability	NN
cord-006229-7yoilsho	6624	16	from	from	IN
cord-006229-7yoilsho	6624	17	10	10	CD
cord-006229-7yoilsho	6624	18	pM	pm	NN
cord-006229-7yoilsho	6624	19	to	to	IN
cord-006229-7yoilsho	6624	20	1	1	CD
cord-006229-7yoilsho	6624	21	µM.	µm.	JJ
cord-006229-7yoilsho	6624	22	Toxicity	toxicity	NN
cord-006229-7yoilsho	6624	23	studies	study	NNS
cord-006229-7yoilsho	6624	24	in	in	IN
cord-006229-7yoilsho	6624	25	BALB	BALB	NNP
cord-006229-7yoilsho	6624	26	/	/	SYM
cord-006229-7yoilsho	6624	27	c	c	NN
cord-006229-7yoilsho	6624	28	mice	mouse	NNS
cord-006229-7yoilsho	6624	29	revealed	reveal	VBD
cord-006229-7yoilsho	6624	30	0.4	0.4	CD
cord-006229-7yoilsho	6624	31	µg	µg	NN
cord-006229-7yoilsho	6624	32	/	/	SYM
cord-006229-7yoilsho	6624	33	mouse	mouse	NN
cord-006229-7yoilsho	6624	34	to	to	TO
cord-006229-7yoilsho	6624	35	be	be	VB
cord-006229-7yoilsho	6624	36	non	non	JJ
cord-006229-7yoilsho	6624	37	-	-	JJ
cord-006229-7yoilsho	6624	38	toxic	toxic	JJ
cord-006229-7yoilsho	6624	39	and	and	CC
cord-006229-7yoilsho	6624	40	maximum	maximum	JJ
cord-006229-7yoilsho	6624	41	tolerated	tolerate	VBN
cord-006229-7yoilsho	6624	42	dose	dose	NN
cord-006229-7yoilsho	6624	43	(	(	-LRB-
cord-006229-7yoilsho	6624	44	MTD	MTD	NNP
cord-006229-7yoilsho	6624	45	)	)	-RRB-
cord-006229-7yoilsho	6624	46	whereas	whereas	IN
cord-006229-7yoilsho	6624	47	40	40	CD
cord-006229-7yoilsho	6624	48	µg	µg	NN
cord-006229-7yoilsho	6624	49	caused	cause	VBN
cord-006229-7yoilsho	6624	50	moribundity	moribundity	NN
cord-006229-7yoilsho	6624	51	accompanied	accompany	VBN
cord-006229-7yoilsho	6624	52	with	with	IN
cord-006229-7yoilsho	6624	53	white	white	JJ
cord-006229-7yoilsho	6624	54	ocular	ocular	JJ
cord-006229-7yoilsho	6624	55	discharge	discharge	NN
cord-006229-7yoilsho	6624	56	.	.	.
cord-006229-7yoilsho	6625	1	Efficacy	efficacy	NN
cord-006229-7yoilsho	6625	2	studies	study	NNS
cord-006229-7yoilsho	6625	3	were	be	VBD
cord-006229-7yoilsho	6625	4	performed	perform	VBN
cord-006229-7yoilsho	6625	5	for	for	IN
cord-006229-7yoilsho	6625	6	a	a	DT
cord-006229-7yoilsho	6625	7	period	period	NN
cord-006229-7yoilsho	6625	8	of	of	IN
cord-006229-7yoilsho	6625	9	28	28	CD
cord-006229-7yoilsho	6625	10	days	day	NNS
cord-006229-7yoilsho	6625	11	.	.	.
cord-006229-7yoilsho	6626	1	The	the	DT
cord-006229-7yoilsho	6626	2	combination	combination	NN
cord-006229-7yoilsho	6626	3	therapy	therapy	NN
cord-006229-7yoilsho	6626	4	showed	show	VBD
cord-006229-7yoilsho	6626	5	that	that	IN
cord-006229-7yoilsho	6626	6	the	the	DT
cord-006229-7yoilsho	6626	7	average	average	JJ
cord-006229-7yoilsho	6626	8	tumor	tumor	NN
cord-006229-7yoilsho	6626	9	volume	volume	NN
cord-006229-7yoilsho	6626	10	measured	measure	VBN
cord-006229-7yoilsho	6626	11	by	by	IN
cord-006229-7yoilsho	6626	12	a	a	DT
cord-006229-7yoilsho	6626	13	digital	digital	JJ
cord-006229-7yoilsho	6626	14	vernier	vernier	NN
cord-006229-7yoilsho	6626	15	caliper	caliper	NN
cord-006229-7yoilsho	6626	16	was	be	VBD
cord-006229-7yoilsho	6626	17	found	find	VBN
cord-006229-7yoilsho	6626	18	to	to	TO
cord-006229-7yoilsho	6626	19	be	be	VB
cord-006229-7yoilsho	6626	20	80	80	CD
cord-006229-7yoilsho	6626	21	%	%	NN
cord-006229-7yoilsho	6626	22	less	less	JJR
cord-006229-7yoilsho	6626	23	than	than	IN
cord-006229-7yoilsho	6626	24	for	for	IN
cord-006229-7yoilsho	6626	25	placebo	placebo	NN
cord-006229-7yoilsho	6626	26	whereas	whereas	IN
cord-006229-7yoilsho	6626	27	single	single	JJ
cord-006229-7yoilsho	6626	28	therapy	therapy	NN
cord-006229-7yoilsho	6626	29	using	use	VBG
cord-006229-7yoilsho	6626	30	dianthin	dianthin	NNP
cord-006229-7yoilsho	6626	31	-	-	HYPH
cord-006229-7yoilsho	6626	32	EGF	EGF	NNP
cord-006229-7yoilsho	6626	33	alone	alone	RB
cord-006229-7yoilsho	6626	34	caused	cause	VBD
cord-006229-7yoilsho	6626	35	a	a	DT
cord-006229-7yoilsho	6626	36	further	further	JJ
cord-006229-7yoilsho	6626	37	increase	increase	NN
cord-006229-7yoilsho	6626	38	in	in	IN
cord-006229-7yoilsho	6626	39	tumor	tumor	NN
cord-006229-7yoilsho	6626	40	volume	volume	NN
cord-006229-7yoilsho	6626	41	which	which	WDT
cord-006229-7yoilsho	6626	42	was	be	VBD
cord-006229-7yoilsho	6626	43	although	although	IN
cord-006229-7yoilsho	6626	44	yet	yet	RB
cord-006229-7yoilsho	6626	45	50	50	CD
cord-006229-7yoilsho	6626	46	%	%	NN
cord-006229-7yoilsho	6626	47	less	less	JJR
cord-006229-7yoilsho	6626	48	when	when	WRB
cord-006229-7yoilsho	6626	49	compared	compare	VBN
cord-006229-7yoilsho	6626	50	to	to	IN
cord-006229-7yoilsho	6626	51	placebo	placebo	NN
cord-006229-7yoilsho	6626	52	.	.	.
cord-006229-7yoilsho	6627	1	Immunohistochemistry	immunohistochemistry	NN
cord-006229-7yoilsho	6627	2	slides	slide	NNS
cord-006229-7yoilsho	6627	3	showed	show	VBD
cord-006229-7yoilsho	6627	4	EGF	EGF	NNP
cord-006229-7yoilsho	6627	5	receptor	receptor	NN
cord-006229-7yoilsho	6627	6	expression	expression	NN
cord-006229-7yoilsho	6627	7	in	in	IN
cord-006229-7yoilsho	6627	8	each	each	DT
cord-006229-7yoilsho	6627	9	of	of	IN
cord-006229-7yoilsho	6627	10	all	all	DT
cord-006229-7yoilsho	6627	11	untreated	untreated	JJ
cord-006229-7yoilsho	6627	12	xenograft	xenograft	NN
cord-006229-7yoilsho	6627	13	tumors	tumor	NNS
cord-006229-7yoilsho	6627	14	,	,	,
cord-006229-7yoilsho	6627	15	which	which	WDT
cord-006229-7yoilsho	6627	16	further	further	RB
cord-006229-7yoilsho	6627	17	confirms	confirm	VBZ
cord-006229-7yoilsho	6627	18	the	the	DT
cord-006229-7yoilsho	6627	19	presence	presence	NN
cord-006229-7yoilsho	6627	20	of	of	IN
cord-006229-7yoilsho	6627	21	EGF	EGF	NNP
cord-006229-7yoilsho	6627	22	receptor	receptor	NN
cord-006229-7yoilsho	6627	23	overexpression	overexpression	NN
cord-006229-7yoilsho	6627	24	in	in	IN
cord-006229-7yoilsho	6627	25	the	the	DT
cord-006229-7yoilsho	6627	26	target	target	NN
cord-006229-7yoilsho	6627	27	BxPC-3	BxPC-3	NNP
cord-006229-7yoilsho	6627	28	cell	cell	NN
cord-006229-7yoilsho	6627	29	line	line	NN
cord-006229-7yoilsho	6627	30	.	.	.
cord-006229-7yoilsho	6628	1	Enlarged	enlarged	JJ
cord-006229-7yoilsho	6628	2	spleen	spleen	NNS
cord-006229-7yoilsho	6628	3	was	be	VBD
cord-006229-7yoilsho	6628	4	only	only	RB
cord-006229-7yoilsho	6628	5	observed	observe	VBN
cord-006229-7yoilsho	6628	6	in	in	IN
cord-006229-7yoilsho	6628	7	untreated	untreated	JJ
cord-006229-7yoilsho	6628	8	xenografts	xenograft	NNS
cord-006229-7yoilsho	6628	9	.	.	.
cord-006229-7yoilsho	6629	1	No	no	DT
cord-006229-7yoilsho	6629	2	significant	significant	JJ
cord-006229-7yoilsho	6629	3	change	change	NN
cord-006229-7yoilsho	6629	4	in	in	IN
cord-006229-7yoilsho	6629	5	various	various	JJ
cord-006229-7yoilsho	6629	6	blood	blood	NN
cord-006229-7yoilsho	6629	7	parameters	parameter	NNS
cord-006229-7yoilsho	6629	8	(	(	-LRB-
cord-006229-7yoilsho	6629	9	RBC	RBC	NNP
cord-006229-7yoilsho	6629	10	counts	count	VBZ
cord-006229-7yoilsho	6629	11	,	,	,
cord-006229-7yoilsho	6629	12	WBC	WBC	NNP
cord-006229-7yoilsho	6629	13	counts	count	VBZ
cord-006229-7yoilsho	6629	14	,	,	,
cord-006229-7yoilsho	6629	15	HGB	HGB	NNP
cord-006229-7yoilsho	6629	16	,	,	,
cord-006229-7yoilsho	6629	17	HCT	HCT	NNP
cord-006229-7yoilsho	6629	18	,	,	,
cord-006229-7yoilsho	6629	19	MCV	MCV	NNP
cord-006229-7yoilsho	6629	20	,	,	,
cord-006229-7yoilsho	6629	21	MCH	MCH	NNP
cord-006229-7yoilsho	6629	22	and	and	CC
cord-006229-7yoilsho	6629	23	MCHC	MCHC	NNP
cord-006229-7yoilsho	6629	24	)	)	-RRB-
cord-006229-7yoilsho	6629	25	were	be	VBD
cord-006229-7yoilsho	6629	26	observed	observe	VBN
cord-006229-7yoilsho	6629	27	on	on	IN
cord-006229-7yoilsho	6629	28	hematological	hematological	JJ
cord-006229-7yoilsho	6629	29	analysis	analysis	NN
cord-006229-7yoilsho	6629	30	except	except	IN
cord-006229-7yoilsho	6629	31	for	for	IN
cord-006229-7yoilsho	6629	32	the	the	DT
cord-006229-7yoilsho	6629	33	platelet	platelet	NN
cord-006229-7yoilsho	6629	34	(	(	-LRB-
cord-006229-7yoilsho	6629	35	PLT	PLT	NNP
cord-006229-7yoilsho	6629	36	)	)	-RRB-
cord-006229-7yoilsho	6629	37	counts	count	VBZ
cord-006229-7yoilsho	6629	38	in	in	IN
cord-006229-7yoilsho	6629	39	comparison	comparison	NN
cord-006229-7yoilsho	6629	40	to	to	IN
cord-006229-7yoilsho	6629	41	healthy	healthy	JJ
cord-006229-7yoilsho	6629	42	male	male	JJ
cord-006229-7yoilsho	6629	43	nude	nude	JJ
cord-006229-7yoilsho	6629	44	mice	mouse	NNS
cord-006229-7yoilsho	6629	45	.	.	.
cord-006229-7yoilsho	6630	1	Conclusion	conclusion	NN
cord-006229-7yoilsho	6630	2	:	:	:
cord-006229-7yoilsho	6631	1	Combination	combination	NN
cord-006229-7yoilsho	6631	2	therapy	therapy	NN
cord-006229-7yoilsho	6631	3	with	with	IN
cord-006229-7yoilsho	6631	4	SO1861	SO1861	NNS
cord-006229-7yoilsho	6631	5	proves	prove	VBZ
cord-006229-7yoilsho	6631	6	to	to	TO
cord-006229-7yoilsho	6631	7	be	be	VB
cord-006229-7yoilsho	6631	8	a	a	DT
cord-006229-7yoilsho	6631	9	promising	promising	JJ
cord-006229-7yoilsho	6631	10	approach	approach	NN
cord-006229-7yoilsho	6631	11	for	for	IN
cord-006229-7yoilsho	6631	12	the	the	DT
cord-006229-7yoilsho	6631	13	targeted	target	VBN
cord-006229-7yoilsho	6631	14	delivery	delivery	NN
cord-006229-7yoilsho	6631	15	of	of	IN
cord-006229-7yoilsho	6631	16	toxins	toxin	NNS
cord-006229-7yoilsho	6631	17	instead	instead	RB
cord-006229-7yoilsho	6631	18	of	of	IN
cord-006229-7yoilsho	6631	19	single	single	JJ
cord-006229-7yoilsho	6631	20	therapy	therapy	NN
cord-006229-7yoilsho	6631	21	administering	administer	VBG
cord-006229-7yoilsho	6631	22	targeted	target	VBN
cord-006229-7yoilsho	6631	23	toxin	toxin	NN
cord-006229-7yoilsho	6631	24	alone	alone	RB
cord-006229-7yoilsho	6631	25	.	.	.
cord-006229-7yoilsho	6632	1	The	the	DT
cord-006229-7yoilsho	6632	2	strategy	strategy	NN
cord-006229-7yoilsho	6632	3	is	be	VBZ
cord-006229-7yoilsho	6632	4	specific	specific	JJ
cord-006229-7yoilsho	6632	5	for	for	IN
cord-006229-7yoilsho	6632	6	EGF	EGF	NNP
cord-006229-7yoilsho	6632	7	receptor	receptor	NN
cord-006229-7yoilsho	6632	8	overexpressing	overexpresse	VBG
cord-006229-7yoilsho	6632	9	tumors	tumor	NNS
cord-006229-7yoilsho	6632	10	such	such	JJ
cord-006229-7yoilsho	6632	11	as	as	IN
cord-006229-7yoilsho	6632	12	pancreatic	pancreatic	JJ
cord-006229-7yoilsho	6632	13	cancer	cancer	NN
cord-006229-7yoilsho	6632	14	.	.	.
cord-006229-7yoilsho	6633	1	Introduction	introduction	NN
cord-006229-7yoilsho	6633	2	:	:	:
cord-006229-7yoilsho	6633	3	Moringa	Moringa	NNP
cord-006229-7yoilsho	6633	4	oleifera	oleifera	NN
cord-006229-7yoilsho	6633	5	(	(	-LRB-
cord-006229-7yoilsho	6633	6	MO	MO	NNP
cord-006229-7yoilsho	6633	7	)	)	-RRB-
cord-006229-7yoilsho	6633	8	is	be	VBZ
cord-006229-7yoilsho	6633	9	a	a	DT
cord-006229-7yoilsho	6633	10	popular	popular	JJ
cord-006229-7yoilsho	6633	11	herbal	herbal	JJ
cord-006229-7yoilsho	6633	12	supplement	supplement	NN
cord-006229-7yoilsho	6633	13	used	use	VBN
cord-006229-7yoilsho	6633	14	for	for	IN
cord-006229-7yoilsho	6633	15	treatment	treatment	NN
cord-006229-7yoilsho	6633	16	and	and	CC
cord-006229-7yoilsho	6633	17	management	management	NN
cord-006229-7yoilsho	6633	18	of	of	IN
cord-006229-7yoilsho	6633	19	diverse	diverse	JJ
cord-006229-7yoilsho	6633	20	diseases	disease	NNS
cord-006229-7yoilsho	6633	21	in	in	IN
cord-006229-7yoilsho	6633	22	sub	sub	JJ
cord-006229-7yoilsho	6633	23	-	-	JJ
cord-006229-7yoilsho	6633	24	Saharan	saharan	JJ
cord-006229-7yoilsho	6633	25	Africa	Africa	NNP
cord-006229-7yoilsho	6633	26	.	.	.
cord-006229-7yoilsho	6634	1	Its	-PRON-	PRP$
cord-006229-7yoilsho	6634	2	intake	intake	NN
cord-006229-7yoilsho	6634	3	among	among	IN
cord-006229-7yoilsho	6634	4	individuals	individual	NNS
cord-006229-7yoilsho	6634	5	infected	infect	VBN
cord-006229-7yoilsho	6634	6	with	with	IN
cord-006229-7yoilsho	6634	7	HIV	HIV	NNP
cord-006229-7yoilsho	6634	8	/	/	SYM
cord-006229-7yoilsho	6634	9	AIDS	AIDS	NNP
cord-006229-7yoilsho	6634	10	has	have	VBZ
cord-006229-7yoilsho	6634	11	increased	increase	VBN
cord-006229-7yoilsho	6634	12	recently	recently	RB
cord-006229-7yoilsho	6634	13	due	due	IN
cord-006229-7yoilsho	6634	14	to	to	IN
cord-006229-7yoilsho	6634	15	the	the	DT
cord-006229-7yoilsho	6634	16	purported	purport	VBN
cord-006229-7yoilsho	6634	17	immune	immune	JJ
cord-006229-7yoilsho	6634	18	boosting	boost	VBG
cord-006229-7yoilsho	6634	19	property	property	NN
cord-006229-7yoilsho	6634	20	.	.	.
cord-006229-7yoilsho	6635	1	Limited	limited	JJ
cord-006229-7yoilsho	6635	2	information	information	NN
cord-006229-7yoilsho	6635	3	,	,	,
cord-006229-7yoilsho	6635	4	however	however	RB
cord-006229-7yoilsho	6635	5	,	,	,
cord-006229-7yoilsho	6635	6	is	be	VBZ
cord-006229-7yoilsho	6635	7	available	available	JJ
cord-006229-7yoilsho	6635	8	regarding	regard	VBG
cord-006229-7yoilsho	6635	9	its	-PRON-	PRP$
cord-006229-7yoilsho	6635	10	potential	potential	NN
cord-006229-7yoilsho	6635	11	to	to	TO
cord-006229-7yoilsho	6635	12	cause	cause	VB
cord-006229-7yoilsho	6635	13	interactions	interaction	NNS
cord-006229-7yoilsho	6635	14	with	with	IN
cord-006229-7yoilsho	6635	15	commonly	commonly	RB
cord-006229-7yoilsho	6635	16	prescribed	prescribe	VBN
cord-006229-7yoilsho	6635	17	medications	medication	NNS
cord-006229-7yoilsho	6635	18	that	that	WDT
cord-006229-7yoilsho	6635	19	are	be	VBP
cord-006229-7yoilsho	6635	20	substrates	substrate	NNS
cord-006229-7yoilsho	6635	21	of	of	IN
cord-006229-7yoilsho	6635	22	CYP3A4	CYP3A4	NNP
cord-006229-7yoilsho	6635	23	and	and	CC
cord-006229-7yoilsho	6635	24	P	p	NN
cord-006229-7yoilsho	6635	25	-	-	HYPH
cord-006229-7yoilsho	6635	26	glycoprotein	glycoprotein	NN
cord-006229-7yoilsho	6635	27	.	.	.
cord-006229-7yoilsho	6636	1	Methods	method	NNS
cord-006229-7yoilsho	6636	2	:	:	:
cord-006229-7yoilsho	6636	3	The	the	DT
cord-006229-7yoilsho	6636	4	methanol	methanol	NN
cord-006229-7yoilsho	6636	5	extract	extract	NN
cord-006229-7yoilsho	6636	6	and	and	CC
cord-006229-7yoilsho	6636	7	four	four	CD
cord-006229-7yoilsho	6636	8	fractions	fraction	NNS
cord-006229-7yoilsho	6636	9	of	of	IN
cord-006229-7yoilsho	6636	10	MO	MO	NNP
cord-006229-7yoilsho	6636	11	were	be	VBD
cord-006229-7yoilsho	6636	12	tested	test	VBN
cord-006229-7yoilsho	6636	13	on	on	IN
cord-006229-7yoilsho	6636	14	recombinant	recombinant	JJ
cord-006229-7yoilsho	6636	15	CYP3A4	cyp3a4	NN
cord-006229-7yoilsho	6636	16	at	at	IN
cord-006229-7yoilsho	6636	17	different	different	JJ
cord-006229-7yoilsho	6636	18	concentrations	concentration	NNS
cord-006229-7yoilsho	6636	19	with	with	IN
cord-006229-7yoilsho	6636	20	and	and	CC
cord-006229-7yoilsho	6636	21	without	without	IN
cord-006229-7yoilsho	6636	22	NADPH	NADPH	NNP
cord-006229-7yoilsho	6636	23	to	to	TO
cord-006229-7yoilsho	6636	24	determine	determine	VB
cord-006229-7yoilsho	6636	25	the	the	DT
cord-006229-7yoilsho	6636	26	IC	IC	NNP
cord-006229-7yoilsho	6636	27	50	50	CD
cord-006229-7yoilsho	6636	28	shift	shift	NN
cord-006229-7yoilsho	6636	29	reduction	reduction	NN
cord-006229-7yoilsho	6636	30	.	.	.
cord-006229-7yoilsho	6637	1	The	the	DT
cord-006229-7yoilsho	6637	2	crude	crude	JJ
cord-006229-7yoilsho	6637	3	methanol	methanol	NN
cord-006229-7yoilsho	6637	4	extract	extract	NN
cord-006229-7yoilsho	6637	5	of	of	IN
cord-006229-7yoilsho	6637	6	MO	MO	NNP
cord-006229-7yoilsho	6637	7	was	be	VBD
cord-006229-7yoilsho	6637	8	incubated	incubate	VBN
cord-006229-7yoilsho	6637	9	with	with	IN
cord-006229-7yoilsho	6637	10	testosterone	testosterone	NN
cord-006229-7yoilsho	6637	11	(	(	-LRB-
cord-006229-7yoilsho	6637	12	TST	TST	NNP
cord-006229-7yoilsho	6637	13	)	)	-RRB-
cord-006229-7yoilsho	6637	14	and	and	CC
cord-006229-7yoilsho	6637	15	cryopreserved	cryopreserve	VBN
cord-006229-7yoilsho	6637	16	hepatocytes	hepatocyte	NNS
cord-006229-7yoilsho	6637	17	to	to	TO
cord-006229-7yoilsho	6637	18	evaluate	evaluate	VB
cord-006229-7yoilsho	6637	19	its	-PRON-	PRP$
cord-006229-7yoilsho	6637	20	influence	influence	NN
cord-006229-7yoilsho	6637	21	on	on	IN
cord-006229-7yoilsho	6637	22	clearance	clearance	NN
cord-006229-7yoilsho	6637	23	of	of	IN
cord-006229-7yoilsho	6637	24	TST	TST	NNP
cord-006229-7yoilsho	6637	25	.	.	.
cord-006229-7yoilsho	6638	1	Effect	effect	NN
cord-006229-7yoilsho	6638	2	of	of	IN
cord-006229-7yoilsho	6638	3	MO	MO	NNP
cord-006229-7yoilsho	6638	4	on	on	IN
cord-006229-7yoilsho	6638	5	the	the	DT
cord-006229-7yoilsho	6638	6	efflux	efflux	NN
cord-006229-7yoilsho	6638	7	transporter	transporter	NN
cord-006229-7yoilsho	6638	8	,	,	,
cord-006229-7yoilsho	6638	9	P	p	NN
cord-006229-7yoilsho	6638	10	-	-	HYPH
cord-006229-7yoilsho	6638	11	glycoprotein	glycoprotein	NN
cord-006229-7yoilsho	6638	12	was	be	VBD
cord-006229-7yoilsho	6638	13	investigated	investigate	VBN
cord-006229-7yoilsho	6638	14	by	by	IN
cord-006229-7yoilsho	6638	15	incubating	incubate	VBG
cord-006229-7yoilsho	6638	16	the	the	DT
cord-006229-7yoilsho	6638	17	methanol	methanol	NN
cord-006229-7yoilsho	6638	18	extract	extract	NN
cord-006229-7yoilsho	6638	19	with	with	IN
cord-006229-7yoilsho	6638	20	MDR1	MDR1	NNP
cord-006229-7yoilsho	6638	21	-MDCKII	-MDCKII	NNP
cord-006229-7yoilsho	6638	22	cells	cell	NNS
cord-006229-7yoilsho	6638	23	.	.	.
cord-006229-7yoilsho	6639	1	Virtual	virtual	JJ
cord-006229-7yoilsho	6639	2	screening	screening	NN
cord-006229-7yoilsho	6639	3	was	be	VBD
cord-006229-7yoilsho	6639	4	conducted	conduct	VBN
cord-006229-7yoilsho	6639	5	to	to	TO
cord-006229-7yoilsho	6639	6	predict	predict	VB
cord-006229-7yoilsho	6639	7	physicochemical	physicochemical	JJ
cord-006229-7yoilsho	6639	8	properties	property	NNS
cord-006229-7yoilsho	6639	9	,	,	,
cord-006229-7yoilsho	6639	10	bioavailability	bioavailability	NN
cord-006229-7yoilsho	6639	11	and	and	CC
cord-006229-7yoilsho	6639	12	interaction	interaction	NN
cord-006229-7yoilsho	6639	13	potential	potential	NN
cord-006229-7yoilsho	6639	14	of	of	IN
cord-006229-7yoilsho	6639	15	phytochemical	phytochemical	JJ
cord-006229-7yoilsho	6639	16	compounds	compound	NNS
cord-006229-7yoilsho	6639	17	unique	unique	JJ
cord-006229-7yoilsho	6639	18	to	to	IN
cord-006229-7yoilsho	6639	19	MO	MO	NNP
cord-006229-7yoilsho	6639	20	using	use	VBG
cord-006229-7yoilsho	6639	21	combination	combination	NN
cord-006229-7yoilsho	6639	22	of	of	IN
cord-006229-7yoilsho	6639	23	molinspiration	molinspiration	NN
cord-006229-7yoilsho	6639	24	version	version	NN
cord-006229-7yoilsho	6639	25	2014.11	2014.11	CD
cord-006229-7yoilsho	6639	26	and	and	CC
cord-006229-7yoilsho	6639	27	admetSAR	admetSAR	NNP
cord-006229-7yoilsho	6639	28	.	.	.
cord-006229-7yoilsho	6640	1	Results	result	NNS
cord-006229-7yoilsho	6640	2	:	:	:
cord-006229-7yoilsho	6641	1	Fractions	fraction	NNS
cord-006229-7yoilsho	6641	2	(	(	-LRB-
cord-006229-7yoilsho	6641	3	F1-F3	F1-F3	NNP
cord-006229-7yoilsho	6641	4	)	)	-RRB-
cord-006229-7yoilsho	6641	5	indicated	indicate	VBD
cord-006229-7yoilsho	6641	6	IC	IC	NNP
cord-006229-7yoilsho	6641	7	50	50	CD
cord-006229-7yoilsho	6641	8	shift	shift	NN
cord-006229-7yoilsho	6641	9	reduction	reduction	NN
cord-006229-7yoilsho	6642	1	≥5	≥5	NNP
cord-006229-7yoilsho	6642	2	post	post	NN
cord-006229-7yoilsho	6642	3	-	-	NN
cord-006229-7yoilsho	6642	4	incubation	incubation	JJ
cord-006229-7yoilsho	6642	5	with	with	IN
cord-006229-7yoilsho	6642	6	and	and	CC
cord-006229-7yoilsho	6642	7	without	without	IN
cord-006229-7yoilsho	6642	8	NADPH	NADPH	NNP
cord-006229-7yoilsho	6642	9	.	.	.
cord-006229-7yoilsho	6643	1	MO	MO	NNP
cord-006229-7yoilsho	6643	2	showed	show	VBD
cord-006229-7yoilsho	6643	3	moderate	moderate	JJ
cord-006229-7yoilsho	6643	4	interaction	interaction	NN
cord-006229-7yoilsho	6643	5	(	(	-LRB-
cord-006229-7yoilsho	6643	6	AUC	AUC	NNP
cord-006229-7yoilsho	6643	7	i	i	NNP
cord-006229-7yoilsho	6644	1	/AUC	/AUC	NNP
cord-006229-7yoilsho	6644	2	=	=	SYM
cord-006229-7yoilsho	6644	3	2.46	2.46	CD
cord-006229-7yoilsho	6644	4	)	)	-RRB-
cord-006229-7yoilsho	6644	5	with	with	IN
cord-006229-7yoilsho	6644	6	TST	TST	NNP
cord-006229-7yoilsho	6644	7	in	in	IN
cord-006229-7yoilsho	6644	8	cryopreserved	cryopreserved	JJ
cord-006229-7yoilsho	6644	9	hepatocytes	hepatocyte	NNS
cord-006229-7yoilsho	6644	10	.	.	.
cord-006229-7yoilsho	6645	1	Also	also	RB
cord-006229-7yoilsho	6645	2	,	,	,
cord-006229-7yoilsho	6645	3	MO	MO	NNP
cord-006229-7yoilsho	6645	4	mildly	mildly	RB
cord-006229-7yoilsho	6645	5	inhibited	inhibit	VBD
cord-006229-7yoilsho	6645	6	the	the	DT
cord-006229-7yoilsho	6645	7	transport	transport	NN
cord-006229-7yoilsho	6645	8	of	of	IN
cord-006229-7yoilsho	6645	9	digoxin	digoxin	NN
cord-006229-7yoilsho	6645	10	(	(	-LRB-
cord-006229-7yoilsho	6645	11	IC	IC	NNP
cord-006229-7yoilsho	6645	12	50	50	CD
cord-006229-7yoilsho	6645	13	=	=	SYM
cord-006229-7yoilsho	6645	14	35.45	35.45	CD
cord-006229-7yoilsho	6645	15	µg	µg	NN
cord-006229-7yoilsho	6645	16	/	/	SYM
cord-006229-7yoilsho	6645	17	mL	ml	NN
cord-006229-7yoilsho	6645	18	)	)	-RRB-
cord-006229-7yoilsho	6645	19	across	across	IN
cord-006229-7yoilsho	6645	20	MDR1	MDR1	NNP
cord-006229-7yoilsho	6645	21	-MDCKII	-MDCKII	NNP
cord-006229-7yoilsho	6645	22	cells	cell	NNS
cord-006229-7yoilsho	6645	23	.	.	.
cord-006229-7yoilsho	6646	1	Niaziminin	Niaziminin	NNP
cord-006229-7yoilsho	6646	2	indicated	indicate	VBD
cord-006229-7yoilsho	6646	3	85.57	85.57	CD
cord-006229-7yoilsho	6646	4	%	%	NN
cord-006229-7yoilsho	6646	5	bioavailablity	bioavailablity	NN
cord-006229-7yoilsho	6646	6	via	via	IN
cord-006229-7yoilsho	6646	7	the	the	DT
cord-006229-7yoilsho	6646	8	human	human	JJ
cord-006229-7yoilsho	6646	9	intestinal	intestinal	JJ
cord-006229-7yoilsho	6646	10	membrane	membrane	NN
cord-006229-7yoilsho	6646	11	with	with	IN
cord-006229-7yoilsho	6646	12	61	61	CD
cord-006229-7yoilsho	6646	13	%	%	NN
cord-006229-7yoilsho	6646	14	chance	chance	NN
cord-006229-7yoilsho	6646	15	of	of	IN
cord-006229-7yoilsho	6646	16	inhibiting	inhibit	VBG
cord-006229-7yoilsho	6646	17	CYP3A4	CYP3A4	NNP
cord-006229-7yoilsho	6646	18	.	.	.
cord-006229-7yoilsho	6646	19	βsitostenone	βsitostenone	NNP
cord-006229-7yoilsho	6646	20	showed	show	VBD
cord-006229-7yoilsho	6646	21	strong	strong	JJ
cord-006229-7yoilsho	6646	22	P	p	NN
cord-006229-7yoilsho	6646	23	-	-	HYPH
cord-006229-7yoilsho	6646	24	gp	gp	NN
cord-006229-7yoilsho	6646	25	inhibition	inhibition	NN
cord-006229-7yoilsho	6646	26	(	(	-LRB-
cord-006229-7yoilsho	6646	27	83.27	83.27	CD
cord-006229-7yoilsho	6646	28	%	%	NN
cord-006229-7yoilsho	6646	29	)	)	-RRB-
cord-006229-7yoilsho	6646	30	with	with	IN
cord-006229-7yoilsho	6646	31	100	100	CD
cord-006229-7yoilsho	6646	32	%	%	NN
cord-006229-7yoilsho	6646	33	absorption	absorption	NN
cord-006229-7yoilsho	6646	34	via	via	IN
cord-006229-7yoilsho	6646	35	the	the	DT
cord-006229-7yoilsho	6646	36	intestine	intestine	NN
cord-006229-7yoilsho	6646	37	.	.	.
cord-006229-7yoilsho	6647	1	Conclusions	conclusion	NNS
cord-006229-7yoilsho	6647	2	:	:	:
cord-006229-7yoilsho	6648	1	MO	MO	NNP
cord-006229-7yoilsho	6648	2	has	have	VBZ
cord-006229-7yoilsho	6648	3	the	the	DT
cord-006229-7yoilsho	6648	4	potential	potential	NN
cord-006229-7yoilsho	6648	5	to	to	TO
cord-006229-7yoilsho	6648	6	inhibit	inhibit	VB
cord-006229-7yoilsho	6648	7	the	the	DT
cord-006229-7yoilsho	6648	8	metabolism	metabolism	NN
cord-006229-7yoilsho	6648	9	or	or	CC
cord-006229-7yoilsho	6648	10	excretion	excretion	NN
cord-006229-7yoilsho	6648	11	of	of	IN
cord-006229-7yoilsho	6648	12	other	other	JJ
cord-006229-7yoilsho	6648	13	medications	medication	NNS
cord-006229-7yoilsho	6648	14	that	that	WDT
cord-006229-7yoilsho	6648	15	are	be	VBP
cord-006229-7yoilsho	6648	16	eliminated	eliminate	VBN
cord-006229-7yoilsho	6648	17	by	by	IN
cord-006229-7yoilsho	6648	18	CYP3A4	CYP3A4	NNP
cord-006229-7yoilsho	6648	19	or	or	CC
cord-006229-7yoilsho	6648	20	P	p	NN
cord-006229-7yoilsho	6648	21	-	-	HYPH
cord-006229-7yoilsho	6648	22	glycoprotein	glycoprotein	NN
cord-006229-7yoilsho	6648	23	,	,	,
cord-006229-7yoilsho	6648	24	respectively	respectively	RB
cord-006229-7yoilsho	6648	25	,	,	,
cord-006229-7yoilsho	6648	26	if	if	IN
cord-006229-7yoilsho	6648	27	adequate	adequate	JJ
cord-006229-7yoilsho	6648	28	amounts	amount	NNS
cord-006229-7yoilsho	6648	29	of	of	IN
cord-006229-7yoilsho	6648	30	the	the	DT
cord-006229-7yoilsho	6648	31	active	active	JJ
cord-006229-7yoilsho	6648	32	constituents	constituent	NNS
cord-006229-7yoilsho	6648	33	such	such	JJ
cord-006229-7yoilsho	6648	34	as	as	IN
cord-006229-7yoilsho	6648	35	niaziminin	niaziminin	NNP
cord-006229-7yoilsho	6648	36	and	and	CC
cord-006229-7yoilsho	6648	37	β	β	NN
cord-006229-7yoilsho	6648	38	-	-	HYPH
cord-006229-7yoilsho	6648	39	sitostenone	sitostenone	NNP
cord-006229-7yoilsho	6648	40	enter	enter	VBP
cord-006229-7yoilsho	6648	41	the	the	DT
cord-006229-7yoilsho	6648	42	circulation	circulation	NN
cord-006229-7yoilsho	6648	43	.	.	.
cord-006229-7yoilsho	6649	1	Background	background	NN
cord-006229-7yoilsho	6649	2	:	:	:
cord-006229-7yoilsho	6650	1	Herb	herb	NN
cord-006229-7yoilsho	6650	2	-	-	HYPH
cord-006229-7yoilsho	6650	3	induced	induce	VBN
cord-006229-7yoilsho	6650	4	liver	liver	NN
cord-006229-7yoilsho	6650	5	injury	injury	NN
cord-006229-7yoilsho	6650	6	(	(	-LRB-
cord-006229-7yoilsho	6650	7	HILI	HILI	NNP
cord-006229-7yoilsho	6650	8	)	)	-RRB-
cord-006229-7yoilsho	6650	9	has	have	VBZ
cord-006229-7yoilsho	6650	10	attracted	attract	VBN
cord-006229-7yoilsho	6650	11	attention	attention	NN
cord-006229-7yoilsho	6650	12	in	in	IN
cord-006229-7yoilsho	6650	13	the	the	DT
cord-006229-7yoilsho	6650	14	past	past	JJ
cord-006229-7yoilsho	6650	15	years	year	NNS
cord-006229-7yoilsho	6650	16	due	due	IN
cord-006229-7yoilsho	6650	17	to	to	IN
cord-006229-7yoilsho	6650	18	an	an	DT
cord-006229-7yoilsho	6650	19	increasing	increase	VBG
cord-006229-7yoilsho	6650	20	number	number	NN
cord-006229-7yoilsho	6650	21	of	of	IN
cord-006229-7yoilsho	6650	22	publications	publication	NNS
cord-006229-7yoilsho	6650	23	reporting	report	VBG
cord-006229-7yoilsho	6650	24	cases	case	NNS
cord-006229-7yoilsho	6650	25	of	of	IN
cord-006229-7yoilsho	6650	26	hepatotoxicity	hepatotoxicity	NN
cord-006229-7yoilsho	6650	27	associated	associate	VBN
cord-006229-7yoilsho	6650	28	with	with	IN
cord-006229-7yoilsho	6650	29	use	use	NN
cord-006229-7yoilsho	6650	30	of	of	IN
cord-006229-7yoilsho	6650	31	phytotherapeutics	phytotherapeutic	NNS
cord-006229-7yoilsho	6650	32	.	.	.
cord-006229-7yoilsho	6651	1	Here	here	RB
cord-006229-7yoilsho	6651	2	,	,	,
cord-006229-7yoilsho	6651	3	we	-PRON-	PRP
cord-006229-7yoilsho	6651	4	present	present	VBP
cord-006229-7yoilsho	6651	5	data	datum	NNS
cord-006229-7yoilsho	6651	6	on	on	IN
cord-006229-7yoilsho	6651	7	HILI	HILI	NNP
cord-006229-7yoilsho	6651	8	from	from	IN
cord-006229-7yoilsho	6651	9	the	the	DT
cord-006229-7yoilsho	6651	10	Berlin	Berlin	NNP
cord-006229-7yoilsho	6651	11	Case	Case	NNP
cord-006229-7yoilsho	6651	12	-	-	HYPH
cord-006229-7yoilsho	6651	13	Control	Control	NNP
cord-006229-7yoilsho	6651	14	Surveillance	Surveillance	NNP
cord-006229-7yoilsho	6651	15	Study	Study	NNP
cord-006229-7yoilsho	6651	16	FAKOS	FAKOS	NNP
cord-006229-7yoilsho	6651	17	.	.	.
cord-006229-7yoilsho	6652	1	Methods	method	NNS
cord-006229-7yoilsho	6652	2	:	:	:
cord-006229-7yoilsho	6652	3	FAKOS	FAKOS	NNP
cord-006229-7yoilsho	6652	4	was	be	VBD
cord-006229-7yoilsho	6652	5	initiated	initiate	VBN
cord-006229-7yoilsho	6652	6	in	in	IN
cord-006229-7yoilsho	6652	7	2000	2000	CD
cord-006229-7yoilsho	6652	8	to	to	TO
cord-006229-7yoilsho	6652	9	study	study	VB
cord-006229-7yoilsho	6652	10	serious	serious	JJ
cord-006229-7yoilsho	6652	11	toxicity	toxicity	NN
cord-006229-7yoilsho	6652	12	of	of	IN
cord-006229-7yoilsho	6652	13	drugs	drug	NNS
cord-006229-7yoilsho	6652	14	including	include	VBG
cord-006229-7yoilsho	6652	15	hepatotoxicity	hepatotoxicity	NN
cord-006229-7yoilsho	6652	16	.	.	.
cord-006229-7yoilsho	6653	1	Potential	potential	JJ
cord-006229-7yoilsho	6653	2	cases	case	NNS
cord-006229-7yoilsho	6653	3	of	of	IN
cord-006229-7yoilsho	6653	4	liver	liver	NN
cord-006229-7yoilsho	6653	5	injury	injury	NN
cord-006229-7yoilsho	6653	6	were	be	VBD
cord-006229-7yoilsho	6653	7	ascertained	ascertain	VBN
cord-006229-7yoilsho	6653	8	in	in	IN
cord-006229-7yoilsho	6653	9	more	more	JJR
cord-006229-7yoilsho	6653	10	than	than	IN
cord-006229-7yoilsho	6653	11	180	180	CD
cord-006229-7yoilsho	6653	12	Departments	department	NNS
cord-006229-7yoilsho	6653	13	of	of	IN
cord-006229-7yoilsho	6653	14	all	all	DT
cord-006229-7yoilsho	6653	15	51	51	CD
cord-006229-7yoilsho	6653	16	Berlin	Berlin	NNP
cord-006229-7yoilsho	6653	17	hospitals	hospital	NNS
cord-006229-7yoilsho	6653	18	from	from	IN
cord-006229-7yoilsho	6653	19	October	October	NNP
cord-006229-7yoilsho	6653	20	2002	2002	CD
cord-006229-7yoilsho	6653	21	until	until	IN
cord-006229-7yoilsho	6653	22	December	December	NNP
cord-006229-7yoilsho	6653	23	2011	2011	CD
cord-006229-7yoilsho	6653	24	.	.	.
cord-006229-7yoilsho	6654	1	Through	through	IN
cord-006229-7yoilsho	6654	2	a	a	DT
cord-006229-7yoilsho	6654	3	standardised	standardised	JJ
cord-006229-7yoilsho	6654	4	face	face	NN
cord-006229-7yoilsho	6654	5	-	-	HYPH
cord-006229-7yoilsho	6654	6	to	to	IN
cord-006229-7yoilsho	6654	7	-	-	HYPH
cord-006229-7yoilsho	6654	8	face	face	NN
cord-006229-7yoilsho	6654	9	interview	interview	NN
cord-006229-7yoilsho	6654	10	and	and	CC
cord-006229-7yoilsho	6654	11	review	review	NN
cord-006229-7yoilsho	6654	12	of	of	IN
cord-006229-7yoilsho	6654	13	medical	medical	JJ
cord-006229-7yoilsho	6654	14	charts	chart	NNS
cord-006229-7yoilsho	6654	15	information	information	NN
cord-006229-7yoilsho	6654	16	on	on	IN
cord-006229-7yoilsho	6654	17	all	all	DT
cord-006229-7yoilsho	6654	18	previous	previous	JJ
cord-006229-7yoilsho	6654	19	intakes	intake	NNS
cord-006229-7yoilsho	6654	20	of	of	IN
cord-006229-7yoilsho	6654	21	drugs	drug	NNS
cord-006229-7yoilsho	6654	22	or	or	CC
cord-006229-7yoilsho	6654	23	herbals	herbal	NNS
cord-006229-7yoilsho	6654	24	,	,	,
cord-006229-7yoilsho	6654	25	on	on	IN
cord-006229-7yoilsho	6654	26	co	co	NNS
cord-006229-7yoilsho	6654	27	-	-	NNS
cord-006229-7yoilsho	6654	28	morbidities	morbidity	NNS
cord-006229-7yoilsho	6654	29	,	,	,
cord-006229-7yoilsho	6654	30	and	and	CC
cord-006229-7yoilsho	6654	31	demographic	demographic	JJ
cord-006229-7yoilsho	6654	32	data	datum	NNS
cord-006229-7yoilsho	6654	33	was	be	VBD
cord-006229-7yoilsho	6654	34	ascertained	ascertain	VBN
cord-006229-7yoilsho	6654	35	.	.	.
cord-006229-7yoilsho	6655	1	Inclusion	inclusion	NN
cord-006229-7yoilsho	6655	2	criteria	criterion	NNS
cord-006229-7yoilsho	6655	3	were	be	VBD
cord-006229-7yoilsho	6655	4	an	an	DT
cord-006229-7yoilsho	6655	5	elevation	elevation	NN
cord-006229-7yoilsho	6655	6	of	of	IN
cord-006229-7yoilsho	6655	7	alanine	alanine	JJ
cord-006229-7yoilsho	6655	8	aminotransferase	aminotransferase	NN
cord-006229-7yoilsho	6655	9	or	or	CC
cord-006229-7yoilsho	6655	10	aspartate	aspartate	NN
cord-006229-7yoilsho	6655	11	aminotransferase	aminotransferase	NN
cord-006229-7yoilsho	6655	12	threefold	threefold	RB
cord-006229-7yoilsho	6655	13	above	above	IN
cord-006229-7yoilsho	6655	14	the	the	DT
cord-006229-7yoilsho	6655	15	upper	upper	JJ
cord-006229-7yoilsho	6655	16	limit	limit	NN
cord-006229-7yoilsho	6655	17	of	of	IN
cord-006229-7yoilsho	6655	18	normal	normal	JJ
cord-006229-7yoilsho	6655	19	or	or	CC
cord-006229-7yoilsho	6655	20	an	an	DT
cord-006229-7yoilsho	6655	21	elevation	elevation	NN
cord-006229-7yoilsho	6655	22	of	of	IN
cord-006229-7yoilsho	6655	23	total	total	JJ
cord-006229-7yoilsho	6655	24	bilirubin	bilirubin	NN
cord-006229-7yoilsho	6655	25	higher	high	JJR
cord-006229-7yoilsho	6655	26	than	than	IN
cord-006229-7yoilsho	6655	27	2	2	CD
cord-006229-7yoilsho	6655	28	mg	mg	NNP
cord-006229-7yoilsho	6655	29	/	/	SYM
cord-006229-7yoilsho	6655	30	dl	dl	NN
cord-006229-7yoilsho	6655	31	.	.	.
cord-006229-7yoilsho	6656	1	Excluded	exclude	VBN
cord-006229-7yoilsho	6656	2	were	be	VBD
cord-006229-7yoilsho	6656	3	patients	patient	NNS
cord-006229-7yoilsho	6656	4	with	with	IN
cord-006229-7yoilsho	6656	5	underlying	underlie	VBG
cord-006229-7yoilsho	6656	6	liver	liver	NN
cord-006229-7yoilsho	6656	7	disease	disease	NN
cord-006229-7yoilsho	6656	8	(	(	-LRB-
cord-006229-7yoilsho	6656	9	e.g.	e.g.	RB
cord-006229-7yoilsho	6656	10	,	,	,
cord-006229-7yoilsho	6656	11	alcoholic	alcoholic	JJ
cord-006229-7yoilsho	6656	12	fatty	fatty	JJ
cord-006229-7yoilsho	6656	13	liver	liver	NN
cord-006229-7yoilsho	6656	14	disease	disease	NN
cord-006229-7yoilsho	6656	15	)	)	-RRB-
cord-006229-7yoilsho	6656	16	.	.	.
cord-006229-7yoilsho	6657	1	Drug	drug	NN
cord-006229-7yoilsho	6657	2	or	or	CC
cord-006229-7yoilsho	6657	3	herbal	herbal	JJ
cord-006229-7yoilsho	6657	4	aetiology	aetiology	NN
cord-006229-7yoilsho	6657	5	was	be	VBD
cord-006229-7yoilsho	6657	6	assessed	assess	VBN
cord-006229-7yoilsho	6657	7	based	base	VBN
cord-006229-7yoilsho	6657	8	on	on	IN
cord-006229-7yoilsho	6657	9	the	the	DT
cord-006229-7yoilsho	6657	10	updated	update	VBN
cord-006229-7yoilsho	6657	11	Council	Council	NNP
cord-006229-7yoilsho	6657	12	for	for	IN
cord-006229-7yoilsho	6657	13	International	International	NNP
cord-006229-7yoilsho	6657	14	Organizations	Organizations	NNPS
cord-006229-7yoilsho	6657	15	of	of	IN
cord-006229-7yoilsho	6657	16	Medical	Medical	NNP
cord-006229-7yoilsho	6657	17	Sciences	Sciences	NNPS
cord-006229-7yoilsho	6657	18	(	(	-LRB-
cord-006229-7yoilsho	6657	19	CIOMS	CIOMS	NNP
cord-006229-7yoilsho	6657	20	)	)	-RRB-
cord-006229-7yoilsho	6657	21	scale	scale	NN
cord-006229-7yoilsho	6657	22	.	.	.
cord-006229-7yoilsho	6658	1	Results	result	NNS
cord-006229-7yoilsho	6658	2	:	:	:
cord-006229-7yoilsho	6658	3	Of	of	IN
cord-006229-7yoilsho	6658	4	all	all	DT
cord-006229-7yoilsho	6658	5	198	198	CD
cord-006229-7yoilsho	6658	6	cases	case	NNS
cord-006229-7yoilsho	6658	7	of	of	IN
cord-006229-7yoilsho	6658	8	hepatotoxicity	hepatotoxicity	NN
cord-006229-7yoilsho	6658	9	included	include	VBN
cord-006229-7yoilsho	6658	10	into	into	IN
cord-006229-7yoilsho	6658	11	the	the	DT
cord-006229-7yoilsho	6658	12	FAKOS	FAKOS	NNP
cord-006229-7yoilsho	6658	13	study	study	NN
cord-006229-7yoilsho	6658	14	,	,	,
cord-006229-7yoilsho	6658	15	herbs	herb	NNS
cord-006229-7yoilsho	6658	16	were	be	VBD
cord-006229-7yoilsho	6658	17	involved	involve	VBN
cord-006229-7yoilsho	6658	18	in	in	IN
cord-006229-7yoilsho	6658	19	ten	ten	CD
cord-006229-7yoilsho	6658	20	cases	case	NNS
cord-006229-7yoilsho	6658	21	(	(	-LRB-
cord-006229-7yoilsho	6658	22	5.1	5.1	CD
cord-006229-7yoilsho	6658	23	%	%	NN
cord-006229-7yoilsho	6658	24	)	)	-RRB-
cord-006229-7yoilsho	6658	25	.	.	.
cord-006229-7yoilsho	6659	1	Demographic	demographic	JJ
cord-006229-7yoilsho	6659	2	,	,	,
cord-006229-7yoilsho	6659	3	clinical	clinical	JJ
cord-006229-7yoilsho	6659	4	,	,	,
cord-006229-7yoilsho	6659	5	and	and	CC
cord-006229-7yoilsho	6659	6	laboratory	laboratory	NN
cord-006229-7yoilsho	6659	7	characteristics	characteristic	NNS
cord-006229-7yoilsho	6659	8	of	of	IN
cord-006229-7yoilsho	6659	9	these	these	DT
cord-006229-7yoilsho	6659	10	ten	ten	CD
cord-006229-7yoilsho	6659	11	cases	case	NNS
cord-006229-7yoilsho	6659	12	are	be	VBP
cord-006229-7yoilsho	6659	13	illustrated	illustrate	VBN
cord-006229-7yoilsho	6659	14	in	in	IN
cord-006229-7yoilsho	6659	15	Table	Table	NNP
cord-006229-7yoilsho	6659	16	1	1	CD
cord-006229-7yoilsho	6659	17	.	.	.
cord-006229-7yoilsho	6660	1	Among	among	IN
cord-006229-7yoilsho	6660	2	the	the	DT
cord-006229-7yoilsho	6660	3	six	six	CD
cord-006229-7yoilsho	6660	4	patients	patient	NNS
cord-006229-7yoilsho	6660	5	with	with	IN
cord-006229-7yoilsho	6660	6	available	available	JJ
cord-006229-7yoilsho	6660	7	liver	liver	NN
cord-006229-7yoilsho	6660	8	biopsy	biopsy	NN
cord-006229-7yoilsho	6660	9	results	result	NNS
cord-006229-7yoilsho	6660	10	,	,	,
cord-006229-7yoilsho	6660	11	five	five	CD
cord-006229-7yoilsho	6660	12	patients	patient	NNS
cord-006229-7yoilsho	6660	13	showed	show	VBD
cord-006229-7yoilsho	6660	14	signs	sign	NNS
cord-006229-7yoilsho	6660	15	of	of	IN
cord-006229-7yoilsho	6660	16	necrosis	necrosis	NN
cord-006229-7yoilsho	6660	17	,	,	,
cord-006229-7yoilsho	6660	18	either	either	CC
cord-006229-7yoilsho	6660	19	disseminated	disseminate	VBN
cord-006229-7yoilsho	6660	20	or	or	CC
cord-006229-7yoilsho	6660	21	predominantly	predominantly	RB
cord-006229-7yoilsho	6660	22	near	near	IN
cord-006229-7yoilsho	6660	23	the	the	DT
cord-006229-7yoilsho	6660	24	central	central	JJ
cord-006229-7yoilsho	6660	25	vein	vein	NN
cord-006229-7yoilsho	6660	26	.	.	.
cord-006229-7yoilsho	6661	1	Portal	portal	JJ
cord-006229-7yoilsho	6661	2	inflammation	inflammation	NN
cord-006229-7yoilsho	6661	3	was	be	VBD
cord-006229-7yoilsho	6661	4	more	more	RBR
cord-006229-7yoilsho	6661	5	common	common	JJ
cord-006229-7yoilsho	6661	6	than	than	IN
cord-006229-7yoilsho	6661	7	lobular	lobular	JJ
cord-006229-7yoilsho	6661	8	inflammation	inflammation	NN
cord-006229-7yoilsho	6661	9	,	,	,
cord-006229-7yoilsho	6661	10	and	and	CC
cord-006229-7yoilsho	6661	11	the	the	DT
cord-006229-7yoilsho	6661	12	infiltrates	infiltrate	NNS
cord-006229-7yoilsho	6661	13	contained	contain	VBN
cord-006229-7yoilsho	6661	14	mostly	mostly	RB
cord-006229-7yoilsho	6661	15	lymphocytes	lymphocyte	NNS
cord-006229-7yoilsho	6661	16	,	,	,
cord-006229-7yoilsho	6661	17	neutrophil	neutrophil	NN
cord-006229-7yoilsho	6661	18	or	or	CC
cord-006229-7yoilsho	6661	19	eosinophil	eosinophil	NN
cord-006229-7yoilsho	6661	20	granulocytes	granulocyte	NNS
cord-006229-7yoilsho	6661	21	.	.	.
cord-006229-7yoilsho	6662	1	Herbal	herbal	JJ
cord-006229-7yoilsho	6662	2	aetiology	aetiology	NN
cord-006229-7yoilsho	6662	3	was	be	VBD
cord-006229-7yoilsho	6662	4	judged	judge	VBN
cord-006229-7yoilsho	6662	5	two	two	CD
cord-006229-7yoilsho	6662	6	times	time	NNS
cord-006229-7yoilsho	6662	7	as	as	IN
cord-006229-7yoilsho	6662	8	probable	probable	JJ
cord-006229-7yoilsho	6662	9	(	(	-LRB-
cord-006229-7yoilsho	6662	10	ayurvedic	ayurvedic	JJ
cord-006229-7yoilsho	6662	11	herb	herb	NN
cord-006229-7yoilsho	6662	12	in	in	IN
cord-006229-7yoilsho	6662	13	patient	patient	NN
cord-006229-7yoilsho	6662	14	1	1	CD
cord-006229-7yoilsho	6662	15	,	,	,
cord-006229-7yoilsho	6662	16	pelargonium	pelargonium	NN
cord-006229-7yoilsho	6662	17	sidoides	sidoide	NNS
cord-006229-7yoilsho	6662	18	in	in	IN
cord-006229-7yoilsho	6662	19	patient	patient	NN
cord-006229-7yoilsho	6662	20	6	6	CD
cord-006229-7yoilsho	6662	21	)	)	-RRB-
cord-006229-7yoilsho	6662	22	,	,	,
cord-006229-7yoilsho	6662	23	and	and	CC
cord-006229-7yoilsho	6662	24	eight	eight	CD
cord-006229-7yoilsho	6662	25	times	time	NNS
cord-006229-7yoilsho	6662	26	as	as	IN
cord-006229-7yoilsho	6662	27	possible	possible	JJ
cord-006229-7yoilsho	6662	28	(	(	-LRB-
cord-006229-7yoilsho	6662	29	valeriana	valeriana	NNP
cord-006229-7yoilsho	6662	30	in	in	IN
cord-006229-7yoilsho	6662	31	patients	patient	NNS
cord-006229-7yoilsho	6662	32	3	3	CD
cord-006229-7yoilsho	6662	33	,	,	,
cord-006229-7yoilsho	6662	34	4	4	CD
cord-006229-7yoilsho	6662	35	,	,	,
cord-006229-7yoilsho	6662	36	8	8	CD
cord-006229-7yoilsho	6662	37	,	,	,
cord-006229-7yoilsho	6662	38	9	9	CD
cord-006229-7yoilsho	6662	39	,	,	,
cord-006229-7yoilsho	6662	40	10	10	CD
cord-006229-7yoilsho	6663	1	,	,	,
cord-006229-7yoilsho	6663	2	mentha	mentha	NNP
cord-006229-7yoilsho	6663	3	piperita	piperita	NNP
cord-006229-7yoilsho	6663	4	in	in	IN
cord-006229-7yoilsho	6663	5	patient	patient	NNP
cord-006229-7yoilsho	6663	6	5	5	CD
cord-006229-7yoilsho	6663	7	,	,	,
cord-006229-7yoilsho	6663	8	hypericum	hypericum	JJ
cord-006229-7yoilsho	6663	9	perforatum	perforatum	NN
cord-006229-7yoilsho	6663	10	in	in	IN
cord-006229-7yoilsho	6663	11	patient	patient	NN
cord-006229-7yoilsho	6663	12	2	2	CD
cord-006229-7yoilsho	6663	13	,	,	,
cord-006229-7yoilsho	6663	14	eucalyptus	eucalyptus	NN
cord-006229-7yoilsho	6663	15	globulus	globulus	NN
cord-006229-7yoilsho	6663	16	in	in	IN
cord-006229-7yoilsho	6663	17	patient	patient	NN
cord-006229-7yoilsho	6663	18	7	7	CD
cord-006229-7yoilsho	6663	19	)	)	-RRB-
cord-006229-7yoilsho	6663	20	.	.	.
cord-006229-7yoilsho	6664	1	In	in	IN
cord-006229-7yoilsho	6664	2	nine	nine	CD
cord-006229-7yoilsho	6664	3	cases	case	NNS
cord-006229-7yoilsho	6664	4	other	other	JJ
cord-006229-7yoilsho	6664	5	non	non	JJ
cord-006229-7yoilsho	6664	6	-	-	JJ
cord-006229-7yoilsho	6664	7	herbal	herbal	JJ
cord-006229-7yoilsho	6664	8	drugs	drug	NNS
cord-006229-7yoilsho	6664	9	were	be	VBD
cord-006229-7yoilsho	6664	10	also	also	RB
cord-006229-7yoilsho	6664	11	suspected	suspect	VBN
cord-006229-7yoilsho	6664	12	as	as	IN
cord-006229-7yoilsho	6664	13	potentially	potentially	RB
cord-006229-7yoilsho	6664	14	hepatotoxic	hepatotoxic	JJ
cord-006229-7yoilsho	6664	15	(	(	-LRB-
cord-006229-7yoilsho	6664	16	exception	exception	NN
cord-006229-7yoilsho	6664	17	:	:	:
cord-006229-7yoilsho	6664	18	patient	patient	NNP
cord-006229-7yoilsho	6664	19	6	6	CD
cord-006229-7yoilsho	6664	20	)	)	-RRB-
cord-006229-7yoilsho	6664	21	.	.	.
cord-006229-7yoilsho	6665	1	Seven	seven	CD
cord-006229-7yoilsho	6665	2	cases	case	NNS
cord-006229-7yoilsho	6665	3	occurred	occur	VBD
cord-006229-7yoilsho	6665	4	in	in	IN
cord-006229-7yoilsho	6665	5	the	the	DT
cord-006229-7yoilsho	6665	6	ambulatory	ambulatory	JJ
cord-006229-7yoilsho	6665	7	setting	setting	NN
cord-006229-7yoilsho	6665	8	requiring	require	VBG
cord-006229-7yoilsho	6665	9	hospitalisation	hospitalisation	NN
cord-006229-7yoilsho	6665	10	,	,	,
cord-006229-7yoilsho	6665	11	three	three	CD
cord-006229-7yoilsho	6665	12	cases	case	NNS
cord-006229-7yoilsho	6665	13	occurred	occur	VBD
cord-006229-7yoilsho	6665	14	during	during	IN
cord-006229-7yoilsho	6665	15	hospital	hospital	NN
cord-006229-7yoilsho	6665	16	stay	stay	NN
cord-006229-7yoilsho	6665	17	.	.	.
cord-006229-7yoilsho	6666	1	Discussion	discussion	NN
cord-006229-7yoilsho	6666	2	:	:	:
cord-006229-7yoilsho	6667	1	This	this	DT
cord-006229-7yoilsho	6667	2	case	case	NN
cord-006229-7yoilsho	6667	3	series	series	NN
cord-006229-7yoilsho	6667	4	provides	provide	VBZ
cord-006229-7yoilsho	6667	5	further	further	JJ
cord-006229-7yoilsho	6667	6	information	information	NN
cord-006229-7yoilsho	6667	7	on	on	IN
cord-006229-7yoilsho	6667	8	laboratory	laboratory	NN
cord-006229-7yoilsho	6667	9	and	and	CC
cord-006229-7yoilsho	6667	10	clinical	clinical	JJ
cord-006229-7yoilsho	6667	11	aspects	aspect	NNS
cord-006229-7yoilsho	6667	12	of	of	IN
cord-006229-7yoilsho	6667	13	HILI	HILI	NNP
cord-006229-7yoilsho	6667	14	.	.	.
cord-006229-7yoilsho	6668	1	It	-PRON-	PRP
cord-006229-7yoilsho	6668	2	corroborates	corroborate	VBZ
cord-006229-7yoilsho	6668	3	known	know	VBN
cord-006229-7yoilsho	6668	4	risks	risk	NNS
cord-006229-7yoilsho	6668	5	for	for	IN
cord-006229-7yoilsho	6668	6	valeriana	valeriana	NNP
cord-006229-7yoilsho	6668	7	and	and	CC
cord-006229-7yoilsho	6668	8	ayurveda	ayurveda	NN
cord-006229-7yoilsho	6668	9	treatment	treatment	NN
cord-006229-7yoilsho	6668	10	,	,	,
cord-006229-7yoilsho	6668	11	and	and	CC
cord-006229-7yoilsho	6668	12	suggests	suggest	VBZ
cord-006229-7yoilsho	6668	13	that	that	IN
cord-006229-7yoilsho	6668	14	further	further	JJ
cord-006229-7yoilsho	6668	15	herbals	herbal	NNS
cord-006229-7yoilsho	6668	16	rarely	rarely	RB
cord-006229-7yoilsho	6668	17	or	or	CC
cord-006229-7yoilsho	6668	18	never	never	RB
cord-006229-7yoilsho	6668	19	associated	associate	VBN
cord-006229-7yoilsho	6668	20	with	with	IN
cord-006229-7yoilsho	6668	21	liver	liver	NN
cord-006229-7yoilsho	6668	22	injury	injury	NN
cord-006229-7yoilsho	6668	23	before	before	IN
cord-006229-7yoilsho	6668	24	such	such	JJ
cord-006229-7yoilsho	6668	25	as	as	IN
cord-006229-7yoilsho	6668	26	pelargonium	pelargonium	NN
cord-006229-7yoilsho	6668	27	sidoides	sidoide	NNS
cord-006229-7yoilsho	6668	28	,	,	,
cord-006229-7yoilsho	6668	29	hypericum	hypericum	NN
cord-006229-7yoilsho	6668	30	perforatum	perforatum	NN
cord-006229-7yoilsho	6668	31	or	or	CC
cord-006229-7yoilsho	6668	32	mentha	mentha	NNP
cord-006229-7yoilsho	6668	33	piperita	piperita	NNP
cord-006229-7yoilsho	6668	34	could	could	MD
cord-006229-7yoilsho	6668	35	also	also	RB
cord-006229-7yoilsho	6668	36	exhibit	exhibit	VB
cord-006229-7yoilsho	6668	37	a	a	DT
cord-006229-7yoilsho	6668	38	hepatotoxic	hepatotoxic	JJ
cord-006229-7yoilsho	6668	39	potential	potential	NN
cord-006229-7yoilsho	6668	40	.	.	.
cord-006229-7yoilsho	6669	1	Clinical	clinical	JJ
cord-006229-7yoilsho	6669	2	routine	routine	NN
cord-006229-7yoilsho	6669	3	often	often	RB
cord-006229-7yoilsho	6669	4	requires	require	VBZ
cord-006229-7yoilsho	6669	5	to	to	TO
cord-006229-7yoilsho	6669	6	evaluate	evaluate	VB
cord-006229-7yoilsho	6669	7	the	the	DT
cord-006229-7yoilsho	6669	8	cause	cause	NN
cord-006229-7yoilsho	6669	9	of	of	IN
cord-006229-7yoilsho	6669	10	a	a	DT
cord-006229-7yoilsho	6669	11	newly	newly	RB
cord-006229-7yoilsho	6669	12	occurring	occur	VBG
cord-006229-7yoilsho	6669	13	adverse	adverse	JJ
cord-006229-7yoilsho	6669	14	event	event	NN
cord-006229-7yoilsho	6669	15	.	.	.
cord-006229-7yoilsho	6670	1	If	if	IN
cord-006229-7yoilsho	6670	2	this	this	DT
cord-006229-7yoilsho	6670	3	event	event	NN
cord-006229-7yoilsho	6670	4	is	be	VBZ
cord-006229-7yoilsho	6670	5	regarded	regard	VBN
cord-006229-7yoilsho	6670	6	to	to	TO
cord-006229-7yoilsho	6670	7	be	be	VB
cord-006229-7yoilsho	6670	8	iatrogen	iatrogen	NNP
cord-006229-7yoilsho	6670	9	,	,	,
cord-006229-7yoilsho	6670	10	further	further	JJ
cord-006229-7yoilsho	6670	11	information	information	NN
cord-006229-7yoilsho	6670	12	of	of	IN
cord-006229-7yoilsho	6670	13	the	the	DT
cord-006229-7yoilsho	6670	14	association	association	NN
cord-006229-7yoilsho	6670	15	between	between	IN
cord-006229-7yoilsho	6670	16	the	the	DT
cord-006229-7yoilsho	6670	17	drugs	drug	NNS
cord-006229-7yoilsho	6670	18	in	in	IN
cord-006229-7yoilsho	6670	19	the	the	DT
cord-006229-7yoilsho	6670	20	current	current	JJ
cord-006229-7yoilsho	6670	21	medication	medication	NN
cord-006229-7yoilsho	6670	22	list	list	NN
cord-006229-7yoilsho	6670	23	and	and	CC
cord-006229-7yoilsho	6670	24	the	the	DT
cord-006229-7yoilsho	6670	25	adverse	adverse	JJ
cord-006229-7yoilsho	6670	26	event	event	NN
cord-006229-7yoilsho	6670	27	is	be	VBZ
cord-006229-7yoilsho	6670	28	needed	need	VBN
cord-006229-7yoilsho	6670	29	.	.	.
cord-006229-7yoilsho	6671	1	This	this	DT
cord-006229-7yoilsho	6671	2	information	information	NN
cord-006229-7yoilsho	6671	3	should	should	MD
cord-006229-7yoilsho	6671	4	ideally	ideally	RB
cord-006229-7yoilsho	6671	5	reflect	reflect	VB
cord-006229-7yoilsho	6671	6	the	the	DT
cord-006229-7yoilsho	6671	7	true	true	JJ
cord-006229-7yoilsho	6671	8	risk	risk	NN
cord-006229-7yoilsho	6671	9	and	and	CC
cord-006229-7yoilsho	6671	10	allow	allow	VB
cord-006229-7yoilsho	6671	11	ranking	ranking	NN
cord-006229-7yoilsho	6671	12	of	of	IN
cord-006229-7yoilsho	6671	13	the	the	DT
cord-006229-7yoilsho	6671	14	drugs	drug	NNS
cord-006229-7yoilsho	6671	15	according	accord	VBG
cord-006229-7yoilsho	6671	16	to	to	IN
cord-006229-7yoilsho	6671	17	this	this	DT
cord-006229-7yoilsho	6671	18	risk	risk	NN
cord-006229-7yoilsho	6671	19	to	to	TO
cord-006229-7yoilsho	6671	20	identify	identify	VB
cord-006229-7yoilsho	6671	21	which	which	WDT
cord-006229-7yoilsho	6671	22	drug	drug	NN
cord-006229-7yoilsho	6671	23	to	to	TO
cord-006229-7yoilsho	6671	24	discontinue	discontinue	VB
cord-006229-7yoilsho	6671	25	first	first	RB
cord-006229-7yoilsho	6671	26	.	.	.
cord-006229-7yoilsho	6672	1	We	-PRON-	PRP
cord-006229-7yoilsho	6672	2	discuss	discuss	VBP
cord-006229-7yoilsho	6672	3	the	the	DT
cord-006229-7yoilsho	6672	4	summary	summary	NN
cord-006229-7yoilsho	6672	5	of	of	IN
cord-006229-7yoilsho	6672	6	product	product	NN
cord-006229-7yoilsho	6672	7	characteristics	characteristic	NNS
cord-006229-7yoilsho	6672	8	(	(	-LRB-
cord-006229-7yoilsho	6672	9	SPC	SPC	NNP
cord-006229-7yoilsho	6672	10	)	)	-RRB-
cord-006229-7yoilsho	6672	11	,	,	,
cord-006229-7yoilsho	6672	12	the	the	DT
cord-006229-7yoilsho	6672	13	SIDER	SIDER	NNP
cord-006229-7yoilsho	6672	14	Side	Side	NNP
cord-006229-7yoilsho	6672	15	Effect	Effect	NNP
cord-006229-7yoilsho	6672	16	Resource	Resource	NNP
cord-006229-7yoilsho	6672	17	and	and	CC
cord-006229-7yoilsho	6672	18	OpenVigil	OpenVigil	NNP
cord-006229-7yoilsho	6672	19	2	2	CD
cord-006229-7yoilsho	6672	20	as	as	IN
cord-006229-7yoilsho	6672	21	possible	possible	JJ
cord-006229-7yoilsho	6672	22	sources	source	NNS
cord-006229-7yoilsho	6672	23	of	of	IN
cord-006229-7yoilsho	6672	24	information	information	NN
cord-006229-7yoilsho	6672	25	.	.	.
cord-006229-7yoilsho	6673	1	SPCs	spc	NNS
cord-006229-7yoilsho	6673	2	are	be	VBP
cord-006229-7yoilsho	6673	3	becoming	become	VBG
cord-006229-7yoilsho	6673	4	more	more	RBR
cord-006229-7yoilsho	6673	5	and	and	CC
cord-006229-7yoilsho	6673	6	more	more	RBR
cord-006229-7yoilsho	6673	7	a	a	DT
cord-006229-7yoilsho	6673	8	vindicative	vindicative	JJ
cord-006229-7yoilsho	6673	9	charter	charter	NN
cord-006229-7yoilsho	6673	10	for	for	IN
cord-006229-7yoilsho	6673	11	pharmaceutical	pharmaceutical	JJ
cord-006229-7yoilsho	6673	12	companies	company	NNS
cord-006229-7yoilsho	6673	13	that	that	WDT
cord-006229-7yoilsho	6673	14	contain	contain	VBP
cord-006229-7yoilsho	6673	15	misleading	misleading	JJ
cord-006229-7yoilsho	6673	16	information	information	NN
cord-006229-7yoilsho	6673	17	which	which	WDT
cord-006229-7yoilsho	6673	18	is	be	VBZ
cord-006229-7yoilsho	6673	19	not	not	RB
cord-006229-7yoilsho	6673	20	based	base	VBN
cord-006229-7yoilsho	6673	21	on	on	IN
cord-006229-7yoilsho	6673	22	evidence	evidence	NN
cord-006229-7yoilsho	6673	23	(	(	-LRB-
cord-006229-7yoilsho	6673	24	ref	ref	NN
cord-006229-7yoilsho	6673	25	.	.	NNP
cord-006229-7yoilsho	6673	26	1	1	CD
cord-006229-7yoilsho	6673	27	)	)	-RRB-
cord-006229-7yoilsho	6673	28	.	.	.
cord-006229-7yoilsho	6674	1	Since	since	IN
cord-006229-7yoilsho	6674	2	it	-PRON-	PRP
cord-006229-7yoilsho	6674	3	relies	rely	VBZ
cord-006229-7yoilsho	6674	4	on	on	IN
cord-006229-7yoilsho	6674	5	the	the	DT
cord-006229-7yoilsho	6674	6	SPCs	spc	NNS
cord-006229-7yoilsho	6674	7	,	,	,
cord-006229-7yoilsho	6674	8	SIDER	SIDER	NNP
cord-006229-7yoilsho	6674	9	inherits	inherit	VBZ
cord-006229-7yoilsho	6674	10	these	these	DT
cord-006229-7yoilsho	6674	11	shortcomings	shortcoming	NNS
cord-006229-7yoilsho	6674	12	and	and	CC
cord-006229-7yoilsho	6674	13	flags	flag	NNS
cord-006229-7yoilsho	6674	14	warnings	warning	NNS
cord-006229-7yoilsho	6674	15	that	that	WDT
cord-006229-7yoilsho	6674	16	result	result	VBP
cord-006229-7yoilsho	6674	17	from	from	IN
cord-006229-7yoilsho	6674	18	confounding	confounding	JJ
cord-006229-7yoilsho	6674	19	factors	factor	NNS
cord-006229-7yoilsho	6674	20	(	(	-LRB-
cord-006229-7yoilsho	6674	21	ref	ref	NN
cord-006229-7yoilsho	6674	22	.	.	.
cord-006229-7yoilsho	6675	1	1	1	LS
cord-006229-7yoilsho	6675	2	,	,	,
cord-006229-7yoilsho	6675	3	fig	fig	NN
cord-006229-7yoilsho	6675	4	.	.	NNP
cord-006229-7yoilsho	6675	5	1	1	CD
cord-006229-7yoilsho	6675	6	)	)	-RRB-
cord-006229-7yoilsho	6675	7	.	.	.
cord-006229-7yoilsho	6676	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	6676	2	,	,	,
cord-006229-7yoilsho	6676	3	if	if	IN
cord-006229-7yoilsho	6676	4	any	any	DT
cord-006229-7yoilsho	6676	5	rates	rate	NNS
cord-006229-7yoilsho	6676	6	are	be	VBP
cord-006229-7yoilsho	6676	7	given	give	VBN
cord-006229-7yoilsho	6676	8	,	,	,
cord-006229-7yoilsho	6676	9	they	-PRON-	PRP
cord-006229-7yoilsho	6676	10	are	be	VBP
cord-006229-7yoilsho	6676	11	not	not	RB
cord-006229-7yoilsho	6676	12	easily	easily	RB
cord-006229-7yoilsho	6676	13	comparable	comparable	JJ
cord-006229-7yoilsho	6676	14	since	since	IN
cord-006229-7yoilsho	6676	15	they	-PRON-	PRP
cord-006229-7yoilsho	6676	16	stem	stem	VBP
cord-006229-7yoilsho	6676	17	from	from	IN
cord-006229-7yoilsho	6676	18	different	different	JJ
cord-006229-7yoilsho	6676	19	studies	study	NNS
cord-006229-7yoilsho	6676	20	.	.	.
cord-006229-7yoilsho	6677	1	Pharmacovigilance	Pharmacovigilance	NNP
cord-006229-7yoilsho	6677	2	data	datum	NNS
cord-006229-7yoilsho	6677	3	are	be	VBP
cord-006229-7yoilsho	6677	4	biased	bias	VBN
cord-006229-7yoilsho	6677	5	by	by	IN
cord-006229-7yoilsho	6677	6	the	the	DT
cord-006229-7yoilsho	6677	7	very	very	JJ
cord-006229-7yoilsho	6677	8	nature	nature	NN
cord-006229-7yoilsho	6677	9	of	of	IN
cord-006229-7yoilsho	6677	10	the	the	DT
cord-006229-7yoilsho	6677	11	data	datum	NNS
cord-006229-7yoilsho	6677	12	and	and	CC
cord-006229-7yoilsho	6677	13	the	the	DT
cord-006229-7yoilsho	6677	14	collection	collection	NN
cord-006229-7yoilsho	6677	15	method	method	NN
cord-006229-7yoilsho	6677	16	.	.	.
cord-006229-7yoilsho	6678	1	However	however	RB
cord-006229-7yoilsho	6678	2	,	,	,
cord-006229-7yoilsho	6678	3	once	once	IN
cord-006229-7yoilsho	6678	4	confounders	confounder	NNS
cord-006229-7yoilsho	6678	5	are	be	VBP
cord-006229-7yoilsho	6678	6	eliminated	eliminate	VBN
cord-006229-7yoilsho	6678	7	,	,	,
cord-006229-7yoilsho	6678	8	pharmacovigilance	pharmacovigilance	NN
cord-006229-7yoilsho	6678	9	offers	offer	VBZ
cord-006229-7yoilsho	6678	10	better	well	JJR
cord-006229-7yoilsho	6678	11	information	information	NN
cord-006229-7yoilsho	6678	12	om	om	IN
cord-006229-7yoilsho	6678	13	how	how	WRB
cord-006229-7yoilsho	6678	14	to	to	TO
cord-006229-7yoilsho	6678	15	rank	rank	VB
cord-006229-7yoilsho	6678	16	the	the	DT
cord-006229-7yoilsho	6678	17	drugs	drug	NNS
cord-006229-7yoilsho	6678	18	than	than	IN
cord-006229-7yoilsho	6678	19	SPCs	spc	NNS
cord-006229-7yoilsho	6678	20	/	/	SYM
cord-006229-7yoilsho	6678	21	SIDER	SIDER	NNP
cord-006229-7yoilsho	6678	22	.	.	.
cord-006229-7yoilsho	6679	1	We	-PRON-	PRP
cord-006229-7yoilsho	6679	2	present	present	VBP
cord-006229-7yoilsho	6679	3	decision	decision	NN
cord-006229-7yoilsho	6679	4	-	-	HYPH
cord-006229-7yoilsho	6679	5	guiding	guide	VBG
cord-006229-7yoilsho	6679	6	information	information	NN
cord-006229-7yoilsho	6679	7	obtained	obtain	VBN
cord-006229-7yoilsho	6679	8	by	by	IN
cord-006229-7yoilsho	6679	9	SIDER	SIDER	NNP
cord-006229-7yoilsho	6679	10	and	and	CC
cord-006229-7yoilsho	6679	11	by	by	IN
cord-006229-7yoilsho	6679	12	OpenVigil	OpenVigil	NNP
cord-006229-7yoilsho	6679	13	2	2	CD
cord-006229-7yoilsho	6679	14	for	for	IN
cord-006229-7yoilsho	6679	15	one	one	CD
cord-006229-7yoilsho	6679	16	of	of	IN
cord-006229-7yoilsho	6679	17	our	-PRON-	PRP$
cord-006229-7yoilsho	6679	18	patients	patient	NNS
cord-006229-7yoilsho	6679	19	(	(	-LRB-
cord-006229-7yoilsho	6679	20	fig	fig	NN
cord-006229-7yoilsho	6679	21	.	.	NNP
cord-006229-7yoilsho	6679	22	2	2	CD
cord-006229-7yoilsho	6679	23	&	&	CC
cord-006229-7yoilsho	6679	24	3	3	CD
cord-006229-7yoilsho	6679	25	)	)	-RRB-
cord-006229-7yoilsho	6679	26	and	and	CC
cord-006229-7yoilsho	6679	27	discuss	discuss	VB
cord-006229-7yoilsho	6679	28	how	how	WRB
cord-006229-7yoilsho	6679	29	this	this	DT
cord-006229-7yoilsho	6679	30	information	information	NN
cord-006229-7yoilsho	6679	31	was	be	VBD
cord-006229-7yoilsho	6679	32	used	use	VBN
cord-006229-7yoilsho	6679	33	to	to	TO
cord-006229-7yoilsho	6679	34	modify	modify	VB
cord-006229-7yoilsho	6679	35	the	the	DT
cord-006229-7yoilsho	6679	36	therapy	therapy	NN
cord-006229-7yoilsho	6679	37	.	.	.
cord-006229-7yoilsho	6680	1	Institut	Institut	NNP
cord-006229-7yoilsho	6680	2	für	für	IN
cord-006229-7yoilsho	6680	3	Naturheilkunde	Naturheilkunde	NNP
cord-006229-7yoilsho	6680	4	und	und	IN
cord-006229-7yoilsho	6680	5	Klinische	Klinische	NNP
cord-006229-7yoilsho	6680	6	Pharmakologie	Pharmakologie	NNP
cord-006229-7yoilsho	6680	7	,	,	,
cord-006229-7yoilsho	6680	8	Universität	Universität	NNP
cord-006229-7yoilsho	6680	9	Ulm	Ulm	NNP
cord-006229-7yoilsho	6680	10	,	,	,
cord-006229-7yoilsho	6680	11	Ulm	Ulm	NNP
cord-006229-7yoilsho	6680	12	,	,	,
cord-006229-7yoilsho	6681	1	Germany	Germany	NNP
cord-006229-7yoilsho	6681	2	Background	Background	NNP
cord-006229-7yoilsho	6681	3	:	:	:
cord-006229-7yoilsho	6682	1	Differences	difference	NNS
cord-006229-7yoilsho	6682	2	(	(	-LRB-
cord-006229-7yoilsho	6682	3	polymorphisms	polymorphism	NNS
cord-006229-7yoilsho	6682	4	)	)	-RRB-
cord-006229-7yoilsho	6682	5	in	in	IN
cord-006229-7yoilsho	6682	6	target	target	NN
cord-006229-7yoilsho	6682	7	genes	gene	NNS
cord-006229-7yoilsho	6682	8	or	or	CC
cord-006229-7yoilsho	6682	9	genes	gene	NNS
cord-006229-7yoilsho	6682	10	encoding	encode	VBG
cord-006229-7yoilsho	6682	11	drug	drug	NN
cord-006229-7yoilsho	6682	12	transport	transport	NN
cord-006229-7yoilsho	6682	13	proteins	protein	NNS
cord-006229-7yoilsho	6682	14	or	or	CC
cord-006229-7yoilsho	6682	15	drug	drug	NN
cord-006229-7yoilsho	6682	16	metabolizing	metabolize	VBG
cord-006229-7yoilsho	6682	17	enzymes	enzyme	NNS
cord-006229-7yoilsho	6682	18	may	may	MD
cord-006229-7yoilsho	6682	19	be	be	VB
cord-006229-7yoilsho	6682	20	responsible	responsible	JJ
cord-006229-7yoilsho	6682	21	,	,	,
cord-006229-7yoilsho	6682	22	among	among	IN
cord-006229-7yoilsho	6682	23	other	other	JJ
cord-006229-7yoilsho	6682	24	factors	factor	NNS
cord-006229-7yoilsho	6682	25	,	,	,
cord-006229-7yoilsho	6682	26	for	for	IN
cord-006229-7yoilsho	6682	27	observed	observed	JJ
cord-006229-7yoilsho	6682	28	variation	variation	NN
cord-006229-7yoilsho	6682	29	in	in	IN
cord-006229-7yoilsho	6682	30	patients	patient	NNS
cord-006229-7yoilsho	6682	31	'	'	POS
cord-006229-7yoilsho	6682	32	response	response	NN
cord-006229-7yoilsho	6682	33	to	to	IN
cord-006229-7yoilsho	6682	34	medications	medication	NNS
cord-006229-7yoilsho	6682	35	.	.	.
cord-006229-7yoilsho	6683	1	Pharmacogenetics	Pharmacogenetics	NNP
cord-006229-7yoilsho	6683	2	aims	aim	VBZ
cord-006229-7yoilsho	6683	3	at	at	IN
cord-006229-7yoilsho	6683	4	identification	identification	NN
cord-006229-7yoilsho	6683	5	of	of	IN
cord-006229-7yoilsho	6683	6	patients	patient	NNS
cord-006229-7yoilsho	6683	7	at	at	IN
cord-006229-7yoilsho	6683	8	higher	high	JJR
cord-006229-7yoilsho	6683	9	,	,	,
cord-006229-7yoilsho	6683	10	genetically	genetically	RB
cord-006229-7yoilsho	6683	11	determined	determine	VBN
cord-006229-7yoilsho	6683	12	,	,	,
cord-006229-7yoilsho	6683	13	risk	risk	NN
cord-006229-7yoilsho	6683	14	of	of	IN
cord-006229-7yoilsho	6683	15	adverse	adverse	JJ
cord-006229-7yoilsho	6683	16	drug	drug	NN
cord-006229-7yoilsho	6683	17	effects	effect	NNS
cord-006229-7yoilsho	6683	18	or	or	CC
cord-006229-7yoilsho	6683	19	ineffective	ineffective	JJ
cord-006229-7yoilsho	6683	20	medication	medication	NN
cord-006229-7yoilsho	6683	21	,	,	,
cord-006229-7yoilsho	6683	22	to	to	TO
cord-006229-7yoilsho	6683	23	modify	modify	VB
cord-006229-7yoilsho	6683	24	dosage	dosage	NN
cord-006229-7yoilsho	6683	25	or	or	CC
cord-006229-7yoilsho	6683	26	switch	switch	VB
cord-006229-7yoilsho	6683	27	to	to	IN
cord-006229-7yoilsho	6683	28	alternative	alternative	JJ
cord-006229-7yoilsho	6683	29	therapy	therapy	NN
cord-006229-7yoilsho	6683	30	.	.	.
cord-006229-7yoilsho	6684	1	There	there	EX
cord-006229-7yoilsho	6684	2	is	be	VBZ
cord-006229-7yoilsho	6684	3	,	,	,
cord-006229-7yoilsho	6684	4	however	however	RB
cord-006229-7yoilsho	6684	5	,	,	,
cord-006229-7yoilsho	6684	6	a	a	DT
cord-006229-7yoilsho	6684	7	lack	lack	NN
cord-006229-7yoilsho	6684	8	of	of	IN
cord-006229-7yoilsho	6684	9	awareness	awareness	NN
cord-006229-7yoilsho	6684	10	of	of	IN
cord-006229-7yoilsho	6684	11	pharmacogenetic	pharmacogenetic	NN
cord-006229-7yoilsho	6684	12	-	-	HYPH
cord-006229-7yoilsho	6684	13	based	base	VBN
cord-006229-7yoilsho	6684	14	clinical	clinical	JJ
cord-006229-7yoilsho	6684	15	practise	practise	NN
cord-006229-7yoilsho	6684	16	guidelines	guideline	NNS
cord-006229-7yoilsho	6684	17	.	.	.
cord-006229-7yoilsho	6685	1	Methods	method	NNS
cord-006229-7yoilsho	6685	2	:	:	:
cord-006229-7yoilsho	6685	3	A	a	DT
cord-006229-7yoilsho	6685	4	systematic	systematic	JJ
cord-006229-7yoilsho	6685	5	literature	literature	NN
cord-006229-7yoilsho	6685	6	review	review	NN
cord-006229-7yoilsho	6685	7	was	be	VBD
cord-006229-7yoilsho	6685	8	conducted	conduct	VBN
cord-006229-7yoilsho	6685	9	which	which	WDT
cord-006229-7yoilsho	6685	10	focused	focus	VBD
cord-006229-7yoilsho	6685	11	on	on	IN
cord-006229-7yoilsho	6685	12	published	publish	VBN
cord-006229-7yoilsho	6685	13	guidelines	guideline	NNS
cord-006229-7yoilsho	6685	14	on	on	IN
cord-006229-7yoilsho	6685	15	genotype	genotype	NN
cord-006229-7yoilsho	6685	16	-	-	HYPH
cord-006229-7yoilsho	6685	17	based	base	VBN
cord-006229-7yoilsho	6685	18	(	(	-LRB-
cord-006229-7yoilsho	6685	19	germ	germ	NN
cord-006229-7yoilsho	6685	20	-	-	HYPH
cord-006229-7yoilsho	6685	21	line	line	NN
cord-006229-7yoilsho	6685	22	genetic	genetic	JJ
cord-006229-7yoilsho	6685	23	variants	variant	NNS
cord-006229-7yoilsho	6685	24	)	)	-RRB-
cord-006229-7yoilsho	6686	1	dosage	dosage	NN
cord-006229-7yoilsho	6686	2	modification	modification	NN
cord-006229-7yoilsho	6686	3	or	or	CC
cord-006229-7yoilsho	6686	4	selection	selection	NN
cord-006229-7yoilsho	6686	5	of	of	IN
cord-006229-7yoilsho	6686	6	drugs	drug	NNS
cord-006229-7yoilsho	6686	7	.	.	.
cord-006229-7yoilsho	6687	1	We	-PRON-	PRP
cord-006229-7yoilsho	6687	2	serched	serche	VBD
cord-006229-7yoilsho	6687	3	the	the	DT
cord-006229-7yoilsho	6687	4	MEDLINE	MEDLINE	NNP
cord-006229-7yoilsho	6687	5	and	and	CC
cord-006229-7yoilsho	6687	6	the	the	DT
cord-006229-7yoilsho	6687	7	Pharmacogenomics	Pharmacogenomics	NNP
cord-006229-7yoilsho	6687	8	Knowledgebase	Knowledgebase	NNP
cord-006229-7yoilsho	6687	9	(	(	-LRB-
cord-006229-7yoilsho	6687	10	PharmGKB	PharmGKB	NNP
cord-006229-7yoilsho	6687	11	)	)	-RRB-
cord-006229-7yoilsho	6687	12	databases	database	NNS
cord-006229-7yoilsho	6687	13	.	.	.
cord-006229-7yoilsho	6688	1	Prescribing	prescribe	VBG
cord-006229-7yoilsho	6688	2	information	information	NN
cord-006229-7yoilsho	6688	3	was	be	VBD
cord-006229-7yoilsho	6688	4	also	also	RB
cord-006229-7yoilsho	6688	5	screened	screen	VBN
cord-006229-7yoilsho	6688	6	for	for	IN
cord-006229-7yoilsho	6688	7	pharmacogenetic	pharmacogenetic	JJ
cord-006229-7yoilsho	6688	8	guidance	guidance	NN
cord-006229-7yoilsho	6688	9	.	.	.
cord-006229-7yoilsho	6689	1	Results	result	NNS
cord-006229-7yoilsho	6689	2	:	:	:
cord-006229-7yoilsho	6690	1	The	the	DT
cord-006229-7yoilsho	6690	2	systematic	systematic	JJ
cord-006229-7yoilsho	6690	3	review	review	NN
cord-006229-7yoilsho	6690	4	revealed	reveal	VBD
cord-006229-7yoilsho	6690	5	recommendations	recommendation	NNS
cord-006229-7yoilsho	6690	6	for	for	IN
cord-006229-7yoilsho	6690	7	61	61	CD
cord-006229-7yoilsho	6690	8	drugs	drug	NNS
cord-006229-7yoilsho	6690	9	(	(	-LRB-
cord-006229-7yoilsho	6690	10	Table	table	NN
cord-006229-7yoilsho	6690	11	)	)	-RRB-
cord-006229-7yoilsho	6690	12	that	that	WDT
cord-006229-7yoilsho	6690	13	enable	enable	VBP
cord-006229-7yoilsho	6690	14	the	the	DT
cord-006229-7yoilsho	6690	15	translation	translation	NN
cord-006229-7yoilsho	6690	16	of	of	IN
cord-006229-7yoilsho	6690	17	genetic	genetic	JJ
cord-006229-7yoilsho	6690	18	test	test	NN
cord-006229-7yoilsho	6690	19	results	result	NNS
cord-006229-7yoilsho	6690	20	into	into	IN
cord-006229-7yoilsho	6690	21	actionable	actionable	JJ
cord-006229-7yoilsho	6690	22	prescribing	prescribing	NN
cord-006229-7yoilsho	6690	23	decisions	decision	NNS
cord-006229-7yoilsho	6690	24	.	.	.
cord-006229-7yoilsho	6691	1	For	for	IN
cord-006229-7yoilsho	6691	2	20	20	CD
cord-006229-7yoilsho	6691	3	%	%	NN
cord-006229-7yoilsho	6691	4	of	of	IN
cord-006229-7yoilsho	6691	5	these	these	DT
cord-006229-7yoilsho	6691	6	drugs	drug	NNS
cord-006229-7yoilsho	6691	7	the	the	DT
cord-006229-7yoilsho	6691	8	respective	respective	JJ
cord-006229-7yoilsho	6691	9	German	german	JJ
cord-006229-7yoilsho	6691	10	drug	drug	NN
cord-006229-7yoilsho	6691	11	labels	label	NNS
cord-006229-7yoilsho	6691	12	recommend	recommend	VBP
cord-006229-7yoilsho	6691	13	or	or	CC
cord-006229-7yoilsho	6691	14	even	even	RB
cord-006229-7yoilsho	6691	15	require	require	VB
cord-006229-7yoilsho	6691	16	pharmacogenetic	pharmacogenetic	JJ
cord-006229-7yoilsho	6691	17	testing	testing	NN
cord-006229-7yoilsho	6691	18	(	(	-LRB-
cord-006229-7yoilsho	6691	19	Table	table	NN
cord-006229-7yoilsho	6691	20	,	,	,
cord-006229-7yoilsho	6691	21	3rd	3rd	JJ
cord-006229-7yoilsho	6691	22	column	column	NN
cord-006229-7yoilsho	6691	23	)	)	-RRB-
cord-006229-7yoilsho	6691	24	.	.	.
cord-006229-7yoilsho	6692	1	Although	although	IN
cord-006229-7yoilsho	6692	2	pharmacogenetic	pharmacogenetic	JJ
cord-006229-7yoilsho	6692	3	testing	testing	NN
cord-006229-7yoilsho	6692	4	is	be	VBZ
cord-006229-7yoilsho	6692	5	recommended	recommend	VBN
cord-006229-7yoilsho	6692	6	,	,	,
cord-006229-7yoilsho	6692	7	the	the	DT
cord-006229-7yoilsho	6692	8	prescribing	prescribe	VBG
cord-006229-7yoilsho	6692	9	information	information	NN
cord-006229-7yoilsho	6692	10	not	not	RB
cord-006229-7yoilsho	6692	11	always	always	RB
cord-006229-7yoilsho	6692	12	provides	provide	VBZ
cord-006229-7yoilsho	6692	13	guidance	guidance	NN
cord-006229-7yoilsho	6692	14	on	on	IN
cord-006229-7yoilsho	6692	15	how	how	WRB
cord-006229-7yoilsho	6692	16	to	to	TO
cord-006229-7yoilsho	6692	17	adjust	adjust	VB
cord-006229-7yoilsho	6692	18	the	the	DT
cord-006229-7yoilsho	6692	19	drug	drug	NN
cord-006229-7yoilsho	6692	20	dosage	dosage	NN
cord-006229-7yoilsho	6692	21	based	base	VBN
cord-006229-7yoilsho	6692	22	on	on	IN
cord-006229-7yoilsho	6692	23	the	the	DT
cord-006229-7yoilsho	6692	24	pharmacogenetic	pharmacogenetic	JJ
cord-006229-7yoilsho	6692	25	test	test	NN
cord-006229-7yoilsho	6692	26	result	result	NN
cord-006229-7yoilsho	6692	27	.	.	.
cord-006229-7yoilsho	6693	1	Compared	compare	VBN
cord-006229-7yoilsho	6693	2	with	with	IN
cord-006229-7yoilsho	6693	3	the	the	DT
cord-006229-7yoilsho	6693	4	German	german	JJ
cord-006229-7yoilsho	6693	5	or	or	CC
cord-006229-7yoilsho	6693	6	European	european	JJ
cord-006229-7yoilsho	6693	7	drug	drug	NN
cord-006229-7yoilsho	6693	8	labels	label	NNS
cord-006229-7yoilsho	6693	9	,	,	,
cord-006229-7yoilsho	6693	10	the	the	DT
cord-006229-7yoilsho	6693	11	FDA	FDA	NNP
cord-006229-7yoilsho	6693	12	drug	drug	NN
cord-006229-7yoilsho	6693	13	labels	label	NNS
cord-006229-7yoilsho	6693	14	povide	povide	VBP
cord-006229-7yoilsho	6693	15	more	more	RBR
cord-006229-7yoilsho	6693	16	detailed	detailed	JJ
cord-006229-7yoilsho	6693	17	information	information	NN
cord-006229-7yoilsho	6693	18	on	on	IN
cord-006229-7yoilsho	6693	19	pharmacogenetic	pharmacogenetic	JJ
cord-006229-7yoilsho	6693	20	dose	dose	NN
cord-006229-7yoilsho	6693	21	modifications	modification	NNS
cord-006229-7yoilsho	6693	22	.	.	.
cord-006229-7yoilsho	6694	1	Conclusions	conclusion	NNS
cord-006229-7yoilsho	6694	2	:	:	:
cord-006229-7yoilsho	6695	1	Academic	academic	JJ
cord-006229-7yoilsho	6695	2	working	work	VBG
cord-006229-7yoilsho	6695	3	groups	group	NNS
cord-006229-7yoilsho	6695	4	have	have	VBP
cord-006229-7yoilsho	6695	5	a	a	DT
cord-006229-7yoilsho	6695	6	front	front	JJ
cord-006229-7yoilsho	6695	7	-	-	HYPH
cord-006229-7yoilsho	6695	8	runner	runner	NN
cord-006229-7yoilsho	6695	9	role	role	NN
cord-006229-7yoilsho	6695	10	in	in	IN
cord-006229-7yoilsho	6695	11	the	the	DT
cord-006229-7yoilsho	6695	12	development	development	NN
cord-006229-7yoilsho	6695	13	of	of	IN
cord-006229-7yoilsho	6695	14	prescribing	prescribe	VBG
cord-006229-7yoilsho	6695	15	recommendations	recommendation	NNS
cord-006229-7yoilsho	6695	16	based	base	VBN
cord-006229-7yoilsho	6695	17	on	on	IN
cord-006229-7yoilsho	6695	18	genetic	genetic	JJ
cord-006229-7yoilsho	6695	19	markers	marker	NNS
cord-006229-7yoilsho	6695	20	.	.	.
cord-006229-7yoilsho	6696	1	To	to	IN
cord-006229-7yoilsho	6696	2	date	date	NN
cord-006229-7yoilsho	6696	3	,	,	,
cord-006229-7yoilsho	6696	4	drug	drug	NN
cord-006229-7yoilsho	6696	5	labels	label	NNS
cord-006229-7yoilsho	6696	6	rarely	rarely	RB
cord-006229-7yoilsho	6696	7	contain	contain	VBP
cord-006229-7yoilsho	6696	8	detailed	detailed	JJ
cord-006229-7yoilsho	6696	9	guidelines	guideline	NNS
cord-006229-7yoilsho	6696	10	how	how	WRB
cord-006229-7yoilsho	6696	11	available	available	JJ
cord-006229-7yoilsho	6696	12	genetic	genetic	JJ
cord-006229-7yoilsho	6696	13	test	test	NN
cord-006229-7yoilsho	6696	14	results	result	NNS
cord-006229-7yoilsho	6696	15	should	should	MD
cord-006229-7yoilsho	6696	16	be	be	VB
cord-006229-7yoilsho	6696	17	used	use	VBN
cord-006229-7yoilsho	6696	18	to	to	TO
cord-006229-7yoilsho	6696	19	adjust	adjust	VB
cord-006229-7yoilsho	6696	20	drug	drug	NN
cord-006229-7yoilsho	6696	21	dosage	dosage	NN
cord-006229-7yoilsho	6696	22	.	.	.
cord-006229-7yoilsho	6697	1	Because	because	IN
cord-006229-7yoilsho	6697	2	pharmacogenetics	pharmacogenetics	NNP
cord-006229-7yoilsho	6697	3	has	have	VBZ
cord-006229-7yoilsho	6697	4	a	a	DT
cord-006229-7yoilsho	6697	5	growing	grow	VBG
cord-006229-7yoilsho	6697	6	role	role	NN
cord-006229-7yoilsho	6697	7	during	during	IN
cord-006229-7yoilsho	6697	8	drug	drug	NN
cord-006229-7yoilsho	6697	9	development	development	NN
cord-006229-7yoilsho	6697	10	and	and	CC
cord-006229-7yoilsho	6697	11	pre	pre	JJ
cord-006229-7yoilsho	6697	12	-	-	JJ
cord-006229-7yoilsho	6697	13	prescription	prescription	JJ
cord-006229-7yoilsho	6697	14	genotyping	genotyping	NN
cord-006229-7yoilsho	6697	15	will	will	MD
cord-006229-7yoilsho	6697	16	become	become	VB
cord-006229-7yoilsho	6697	17	more	more	RBR
cord-006229-7yoilsho	6697	18	widespread	widespread	JJ
cord-006229-7yoilsho	6697	19	,	,	,
cord-006229-7yoilsho	6697	20	it	-PRON-	PRP
cord-006229-7yoilsho	6697	21	is	be	VBZ
cord-006229-7yoilsho	6697	22	expected	expect	VBN
cord-006229-7yoilsho	6697	23	that	that	IN
cord-006229-7yoilsho	6697	24	specific	specific	JJ
cord-006229-7yoilsho	6697	25	pharmacogenetic	pharmacogenetic	JJ
cord-006229-7yoilsho	6697	26	guidance	guidance	NN
cord-006229-7yoilsho	6697	27	for	for	IN
cord-006229-7yoilsho	6697	28	the	the	DT
cord-006229-7yoilsho	6697	29	treating	treat	VBG
cord-006229-7yoilsho	6697	30	physicians	physician	NNS
cord-006229-7yoilsho	6697	31	will	will	MD
cord-006229-7yoilsho	6697	32	become	become	VB
cord-006229-7yoilsho	6697	33	increasingly	increasingly	RB
cord-006229-7yoilsho	6697	34	important	important	JJ
cord-006229-7yoilsho	6697	35	.	.	.
cord-006229-7yoilsho	6698	1	Bisphenol	Bisphenol	NNP
cord-006229-7yoilsho	6698	2	A	A	NNP
cord-006229-7yoilsho	6698	3	(	(	-LRB-
cord-006229-7yoilsho	6698	4	BPA	BPA	NNP
cord-006229-7yoilsho	6698	5	)	)	-RRB-
cord-006229-7yoilsho	6698	6	is	be	VBZ
cord-006229-7yoilsho	6698	7	a	a	DT
cord-006229-7yoilsho	6698	8	high	high	JJ
cord-006229-7yoilsho	6698	9	production	production	NN
cord-006229-7yoilsho	6698	10	volume	volume	NN
cord-006229-7yoilsho	6698	11	compound	compound	NN
cord-006229-7yoilsho	6698	12	mainly	mainly	RB
cord-006229-7yoilsho	6698	13	used	use	VBD
cord-006229-7yoilsho	6698	14	as	as	IN
cord-006229-7yoilsho	6698	15	a	a	DT
cord-006229-7yoilsho	6698	16	monomer	monomer	NN
cord-006229-7yoilsho	6698	17	to	to	TO
cord-006229-7yoilsho	6698	18	make	make	VB
cord-006229-7yoilsho	6698	19	polymers	polymer	NNS
cord-006229-7yoilsho	6698	20	for	for	IN
cord-006229-7yoilsho	6698	21	various	various	JJ
cord-006229-7yoilsho	6698	22	applications	application	NNS
cord-006229-7yoilsho	6698	23	,	,	,
cord-006229-7yoilsho	6698	24	including	include	VBG
cord-006229-7yoilsho	6698	25	food	food	NN
cord-006229-7yoilsho	6698	26	-	-	HYPH
cord-006229-7yoilsho	6698	27	contact	contact	NN
cord-006229-7yoilsho	6698	28	applications	application	NNS
cord-006229-7yoilsho	6698	29	.	.	.
cord-006229-7yoilsho	6699	1	People	People	NNS
cord-006229-7yoilsho	6699	2	are	be	VBP
cord-006229-7yoilsho	6699	3	exposed	expose	VBN
cord-006229-7yoilsho	6699	4	to	to	IN
cord-006229-7yoilsho	6699	5	low	low	JJ
cord-006229-7yoilsho	6699	6	levels	level	NNS
cord-006229-7yoilsho	6699	7	of	of	IN
cord-006229-7yoilsho	6699	8	BPA	bpa	NN
cord-006229-7yoilsho	6699	9	because	because	IN
cord-006229-7yoilsho	6699	10	very	very	RB
cord-006229-7yoilsho	6699	11	small	small	JJ
cord-006229-7yoilsho	6699	12	amounts	amount	NNS
cord-006229-7yoilsho	6699	13	of	of	IN
cord-006229-7yoilsho	6699	14	BPA	BPA	NNP
cord-006229-7yoilsho	6699	15	may	may	MD
cord-006229-7yoilsho	6699	16	migrate	migrate	VB
cord-006229-7yoilsho	6699	17	from	from	IN
cord-006229-7yoilsho	6699	18	the	the	DT
cord-006229-7yoilsho	6699	19	food	food	NN
cord-006229-7yoilsho	6699	20	packaging	packaging	NN
cord-006229-7yoilsho	6699	21	into	into	IN
cord-006229-7yoilsho	6699	22	foods	food	NNS
cord-006229-7yoilsho	6699	23	or	or	CC
cord-006229-7yoilsho	6699	24	beverages	beverage	NNS
cord-006229-7yoilsho	6699	25	.	.	.
cord-006229-7yoilsho	6700	1	However	however	RB
cord-006229-7yoilsho	6700	2	,	,	,
cord-006229-7yoilsho	6700	3	other	other	JJ
cord-006229-7yoilsho	6700	4	potential	potential	JJ
cord-006229-7yoilsho	6700	5	sources	source	NNS
cord-006229-7yoilsho	6700	6	of	of	IN
cord-006229-7yoilsho	6700	7	exposure	exposure	NN
cord-006229-7yoilsho	6700	8	,	,	,
cord-006229-7yoilsho	6700	9	such	such	JJ
cord-006229-7yoilsho	6700	10	as	as	IN
cord-006229-7yoilsho	6700	11	dermal	dermal	JJ
cord-006229-7yoilsho	6700	12	contact	contact	NN
cord-006229-7yoilsho	6700	13	have	have	VBP
cord-006229-7yoilsho	6700	14	also	also	RB
cord-006229-7yoilsho	6700	15	been	be	VBN
cord-006229-7yoilsho	6700	16	identified	identify	VBN
cord-006229-7yoilsho	6700	17	(	(	-LRB-
cord-006229-7yoilsho	6700	18	EFSA	EFSA	NNP
cord-006229-7yoilsho	6700	19	,	,	,
cord-006229-7yoilsho	6700	20	2015	2015	CD
cord-006229-7yoilsho	6700	21	)	)	-RRB-
cord-006229-7yoilsho	6700	22	.	.	.
cord-006229-7yoilsho	6701	1	A	a	DT
cord-006229-7yoilsho	6701	2	substance	substance	NN
cord-006229-7yoilsho	6701	3	evaluation	evaluation	NN
cord-006229-7yoilsho	6701	4	process	process	NN
cord-006229-7yoilsho	6701	5	(	(	-LRB-
cord-006229-7yoilsho	6701	6	CoRAP	CoRAP	NFP
cord-006229-7yoilsho	6701	7	)	)	-RRB-
cord-006229-7yoilsho	6701	8	was	be	VBD
cord-006229-7yoilsho	6701	9	initiated	initiate	VBN
cord-006229-7yoilsho	6701	10	for	for	IN
cord-006229-7yoilsho	6701	11	BPA	BPA	NNP
cord-006229-7yoilsho	6701	12	by	by	IN
cord-006229-7yoilsho	6701	13	the	the	DT
cord-006229-7yoilsho	6701	14	European	European	NNP
cord-006229-7yoilsho	6701	15	Chemicals	Chemicals	NNPS
cord-006229-7yoilsho	6701	16	Agency	Agency	NNP
cord-006229-7yoilsho	6701	17	(	(	-LRB-
cord-006229-7yoilsho	6701	18	ECHA	ECHA	NNP
cord-006229-7yoilsho	6701	19	)	)	-RRB-
cord-006229-7yoilsho	6701	20	.	.	.
cord-006229-7yoilsho	6702	1	As	as	IN
cord-006229-7yoilsho	6702	2	part	part	NN
cord-006229-7yoilsho	6702	3	of	of	IN
cord-006229-7yoilsho	6702	4	the	the	DT
cord-006229-7yoilsho	6702	5	safety	safety	NN
cord-006229-7yoilsho	6702	6	evaluation	evaluation	NN
cord-006229-7yoilsho	6702	7	of	of	IN
cord-006229-7yoilsho	6702	8	BPA	BPA	NNP
cord-006229-7yoilsho	6702	9	,	,	,
cord-006229-7yoilsho	6702	10	a	a	DT
cord-006229-7yoilsho	6702	11	study	study	NN
cord-006229-7yoilsho	6702	12	was	be	VBD
cord-006229-7yoilsho	6702	13	required	require	VBN
cord-006229-7yoilsho	6702	14	by	by	IN
cord-006229-7yoilsho	6702	15	ECHA	ECHA	NNS
cord-006229-7yoilsho	6702	16	to	to	TO
cord-006229-7yoilsho	6702	17	assess	assess	VB
cord-006229-7yoilsho	6702	18	absorption	absorption	NN
cord-006229-7yoilsho	6702	19	and	and	CC
cord-006229-7yoilsho	6702	20	metabolism	metabolism	NN
cord-006229-7yoilsho	6702	21	of	of	IN
cord-006229-7yoilsho	6702	22	BPA	BPA	NNP
cord-006229-7yoilsho	6702	23	following	follow	VBG
cord-006229-7yoilsho	6702	24	dermal	dermal	JJ
cord-006229-7yoilsho	6702	25	exposure	exposure	NN
cord-006229-7yoilsho	6702	26	to	to	IN
cord-006229-7yoilsho	6702	27	human	human	JJ
cord-006229-7yoilsho	6702	28	skin	skin	NN
cord-006229-7yoilsho	6702	29	.	.	.
cord-006229-7yoilsho	6703	1	An	an	DT
cord-006229-7yoilsho	6703	2	in	in	IN
cord-006229-7yoilsho	6703	3	vitro	vitro	FW
cord-006229-7yoilsho	6703	4	study	study	NN
cord-006229-7yoilsho	6703	5	with	with	IN
cord-006229-7yoilsho	6703	6	human	human	JJ
cord-006229-7yoilsho	6703	7	skin	skin	NN
cord-006229-7yoilsho	6703	8	was	be	VBD
cord-006229-7yoilsho	6703	9	requested	request	VBN
cord-006229-7yoilsho	6703	10	according	accord	VBG
cord-006229-7yoilsho	6703	11	to	to	IN
cord-006229-7yoilsho	6703	12	OECD	OECD	NNP
cord-006229-7yoilsho	6703	13	TG	TG	NNP
cord-006229-7yoilsho	6703	14	428	428	CD
cord-006229-7yoilsho	6703	15	under	under	IN
cord-006229-7yoilsho	6703	16	consideration	consideration	NN
cord-006229-7yoilsho	6703	17	of	of	IN
cord-006229-7yoilsho	6703	18	the	the	DT
cord-006229-7yoilsho	6703	19	Scientific	Scientific	NNP
cord-006229-7yoilsho	6703	20	Committee	Committee	NNP
cord-006229-7yoilsho	6703	21	on	on	IN
cord-006229-7yoilsho	6703	22	Consumer	Consumer	NNP
cord-006229-7yoilsho	6703	23	Safety	Safety	NNP
cord-006229-7yoilsho	6703	24	(	(	-LRB-
cord-006229-7yoilsho	6703	25	SCCS	SCCS	NNP
cord-006229-7yoilsho	6703	26	)	)	-RRB-
cord-006229-7yoilsho	6703	27	criteria	criterion	NNS
cord-006229-7yoilsho	6703	28	for	for	IN
cord-006229-7yoilsho	6703	29	the	the	DT
cord-006229-7yoilsho	6703	30	in	in	FW
cord-006229-7yoilsho	6703	31	vitro	vitro	FW
cord-006229-7yoilsho	6703	32	assessment	assessment	NN
cord-006229-7yoilsho	6703	33	of	of	IN
cord-006229-7yoilsho	6703	34	dermal	dermal	JJ
cord-006229-7yoilsho	6703	35	absorption	absorption	NN
cord-006229-7yoilsho	6703	36	.	.	.
cord-006229-7yoilsho	6704	1	To	to	TO
cord-006229-7yoilsho	6704	2	investigate	investigate	VB
cord-006229-7yoilsho	6704	3	potential	potential	JJ
cord-006229-7yoilsho	6704	4	dermal	dermal	JJ
cord-006229-7yoilsho	6704	5	BPA	BPA	NNP
cord-006229-7yoilsho	6704	6	metabolism	metabolism	NN
cord-006229-7yoilsho	6704	7	fresh	fresh	JJ
cord-006229-7yoilsho	6704	8	human	human	JJ
cord-006229-7yoilsho	6704	9	skin	skin	NN
cord-006229-7yoilsho	6704	10	was	be	VBD
cord-006229-7yoilsho	6704	11	used	use	VBN
cord-006229-7yoilsho	6704	12	.	.	.
cord-006229-7yoilsho	6705	1	Abdominal	abdominal	JJ
cord-006229-7yoilsho	6705	2	skin	skin	NN
cord-006229-7yoilsho	6705	3	was	be	VBD
cord-006229-7yoilsho	6705	4	obtained	obtain	VBN
cord-006229-7yoilsho	6705	5	fresh	fresh	JJ
cord-006229-7yoilsho	6705	6	from	from	IN
cord-006229-7yoilsho	6705	7	surgery	surgery	NN
cord-006229-7yoilsho	6705	8	from	from	IN
cord-006229-7yoilsho	6705	9	4	4	CD
cord-006229-7yoilsho	6705	10	different	different	JJ
cord-006229-7yoilsho	6705	11	donors	donor	NNS
cord-006229-7yoilsho	6705	12	.	.	.
cord-006229-7yoilsho	6706	1	Split	split	NN
cord-006229-7yoilsho	6706	2	-	-	HYPH
cord-006229-7yoilsho	6706	3	thickness	thickness	NN
cord-006229-7yoilsho	6706	4	human	human	JJ
cord-006229-7yoilsho	6706	5	skin	skin	NN
cord-006229-7yoilsho	6706	6	membranes	membrane	NNS
cord-006229-7yoilsho	6706	7	were	be	VBD
cord-006229-7yoilsho	6706	8	mounted	mount	VBN
cord-006229-7yoilsho	6706	9	into	into	IN
cord-006229-7yoilsho	6706	10	flow	flow	NN
cord-006229-7yoilsho	6706	11	-	-	HYPH
cord-006229-7yoilsho	6706	12	through	through	RP
cord-006229-7yoilsho	6706	13	diffusion	diffusion	NN
cord-006229-7yoilsho	6706	14	cells	cell	NNS
cord-006229-7yoilsho	6706	15	(	(	-LRB-
cord-006229-7yoilsho	6706	16	n=4	n=4	JJ
cord-006229-7yoilsho	6706	17	per	per	IN
cord-006229-7yoilsho	6706	18	dose	dose	NN
cord-006229-7yoilsho	6706	19	and	and	CC
cord-006229-7yoilsho	6706	20	donor	donor	NN
cord-006229-7yoilsho	6706	21	)	)	-RRB-
cord-006229-7yoilsho	6706	22	and	and	CC
cord-006229-7yoilsho	6706	23	the	the	DT
cord-006229-7yoilsho	6706	24	receptor	receptor	NN
cord-006229-7yoilsho	6706	25	fluid	fluid	NN
cord-006229-7yoilsho	6706	26	was	be	VBD
cord-006229-7yoilsho	6706	27	pumped	pump	VBN
cord-006229-7yoilsho	6706	28	underneath	underneath	IN
cord-006229-7yoilsho	6706	29	the	the	DT
cord-006229-7yoilsho	6706	30	skin	skin	NN
cord-006229-7yoilsho	6706	31	at	at	IN
cord-006229-7yoilsho	6706	32	a	a	DT
cord-006229-7yoilsho	6706	33	constant	constant	JJ
cord-006229-7yoilsho	6706	34	flow	flow	NN
cord-006229-7yoilsho	6706	35	rate	rate	NN
cord-006229-7yoilsho	6706	36	.	.	.
cord-006229-7yoilsho	6707	1	The	the	DT
cord-006229-7yoilsho	6707	2	skin	skin	NN
cord-006229-7yoilsho	6707	3	surface	surface	NN
cord-006229-7yoilsho	6707	4	temperature	temperature	NN
cord-006229-7yoilsho	6707	5	was	be	VBD
cord-006229-7yoilsho	6707	6	maintained	maintain	VBN
cord-006229-7yoilsho	6707	7	at	at	IN
cord-006229-7yoilsho	6707	8	32	32	CD
cord-006229-7yoilsho	6707	9	°	°	NN
cord-006229-7yoilsho	6707	10	C	c	NN
cord-006229-7yoilsho	6707	11	throughout	throughout	IN
cord-006229-7yoilsho	6707	12	the	the	DT
cord-006229-7yoilsho	6707	13	experiment	experiment	NN
cord-006229-7yoilsho	6707	14	and	and	CC
cord-006229-7yoilsho	6707	15	electrical	electrical	JJ
cord-006229-7yoilsho	6707	16	resistance	resistance	NN
cord-006229-7yoilsho	6707	17	barrier	barrier	NN
cord-006229-7yoilsho	6707	18	integrity	integrity	NN
cord-006229-7yoilsho	6707	19	testing	testing	NN
cord-006229-7yoilsho	6707	20	was	be	VBD
cord-006229-7yoilsho	6707	21	performed	perform	VBN
cord-006229-7yoilsho	6707	22	at	at	IN
cord-006229-7yoilsho	6707	23	the	the	DT
cord-006229-7yoilsho	6707	24	start	start	NN
cord-006229-7yoilsho	6707	25	(	(	-LRB-
cord-006229-7yoilsho	6707	26	0	0	CD
cord-006229-7yoilsho	6707	27	h	h	NN
cord-006229-7yoilsho	6707	28	)	)	-RRB-
cord-006229-7yoilsho	6707	29	and	and	CC
cord-006229-7yoilsho	6707	30	end	end	NN
cord-006229-7yoilsho	6707	31	of	of	IN
cord-006229-7yoilsho	6707	32	the	the	DT
cord-006229-7yoilsho	6707	33	experiment	experiment	NN
cord-006229-7yoilsho	6707	34	(	(	-LRB-
cord-006229-7yoilsho	6707	35	24	24	CD
cord-006229-7yoilsho	6707	36	h	h	NN
cord-006229-7yoilsho	6707	37	)	)	-RRB-
cord-006229-7yoilsho	6707	38	.	.	.
cord-006229-7yoilsho	6708	1	Four	four	CD
cord-006229-7yoilsho	6708	2	test	test	NN
cord-006229-7yoilsho	6708	3	preparations	preparation	NNS
cord-006229-7yoilsho	6708	4	at	at	IN
cord-006229-7yoilsho	6708	5	final	final	JJ
cord-006229-7yoilsho	6708	6	BPA	BPA	NNP
cord-006229-7yoilsho	6708	7	concentrations	concentration	NNS
cord-006229-7yoilsho	6708	8	of	of	IN
cord-006229-7yoilsho	6708	9	2.4	2.4	CD
cord-006229-7yoilsho	6708	10	,	,	,
cord-006229-7yoilsho	6708	11	12	12	CD
cord-006229-7yoilsho	6708	12	,	,	,
cord-006229-7yoilsho	6708	13	60	60	CD
cord-006229-7yoilsho	6708	14	,	,	,
cord-006229-7yoilsho	6708	15	and	and	CC
cord-006229-7yoilsho	6708	16	300mg	300mg	NNP
cord-006229-7yoilsho	6708	17	/	/	SYM
cord-006229-7yoilsho	6708	18	L	L	NNP
cord-006229-7yoilsho	6708	19	were	be	VBD
cord-006229-7yoilsho	6708	20	investigated	investigate	VBN
cord-006229-7yoilsho	6708	21	.	.	.
cord-006229-7yoilsho	6709	1	The	the	DT
cord-006229-7yoilsho	6709	2	highest	high	JJS
cord-006229-7yoilsho	6709	3	concentration	concentration	NN
cord-006229-7yoilsho	6709	4	was	be	VBD
cord-006229-7yoilsho	6709	5	chosen	choose	VBN
cord-006229-7yoilsho	6709	6	based	base	VBN
cord-006229-7yoilsho	6709	7	on	on	IN
cord-006229-7yoilsho	6709	8	the	the	DT
cord-006229-7yoilsho	6709	9	maximum	maximum	JJ
cord-006229-7yoilsho	6709	10	solubility	solubility	NN
cord-006229-7yoilsho	6709	11	of	of	IN
cord-006229-7yoilsho	6709	12	BPA	BPA	NNP
cord-006229-7yoilsho	6709	13	in	in	IN
cord-006229-7yoilsho	6709	14	water	water	NN
cord-006229-7yoilsho	6709	15	and	and	CC
cord-006229-7yoilsho	6709	16	the	the	DT
cord-006229-7yoilsho	6709	17	lowest	low	JJS
cord-006229-7yoilsho	6709	18	concenration	concenration	NN
cord-006229-7yoilsho	6709	19	was	be	VBD
cord-006229-7yoilsho	6709	20	chosen	choose	VBN
cord-006229-7yoilsho	6709	21	based	base	VBN
cord-006229-7yoilsho	6709	22	upon	upon	IN
cord-006229-7yoilsho	6709	23	the	the	DT
cord-006229-7yoilsho	6709	24	specific	specific	JJ
cord-006229-7yoilsho	6709	25	activity	activity	NN
cord-006229-7yoilsho	6709	26	of	of	IN
cord-006229-7yoilsho	6709	27	the	the	DT
cord-006229-7yoilsho	6709	28	radiolabelled	radiolabelled	JJ
cord-006229-7yoilsho	6709	29	[	[	-LRB-
cord-006229-7yoilsho	6709	30	14	14	CD
cord-006229-7yoilsho	6709	31	C]-BPA	C]-BPA	NNS
cord-006229-7yoilsho	6709	32	that	that	WDT
cord-006229-7yoilsho	6709	33	could	could	MD
cord-006229-7yoilsho	6709	34	be	be	VB
cord-006229-7yoilsho	6709	35	used	use	VBN
cord-006229-7yoilsho	6709	36	for	for	IN
cord-006229-7yoilsho	6709	37	mass	mass	JJ
cord-006229-7yoilsho	6709	38	balance	balance	NN
cord-006229-7yoilsho	6709	39	.	.	.
cord-006229-7yoilsho	6710	1	Percutaneous	Percutaneous	NNP
cord-006229-7yoilsho	6710	2	absorption	absorption	NN
cord-006229-7yoilsho	6710	3	was	be	VBD
cord-006229-7yoilsho	6710	4	assessed	assess	VBN
cord-006229-7yoilsho	6710	5	by	by	IN
cord-006229-7yoilsho	6710	6	collecting	collect	VBG
cord-006229-7yoilsho	6710	7	receptor	receptor	NN
cord-006229-7yoilsho	6710	8	fluid	fluid	NN
cord-006229-7yoilsho	6710	9	(	(	-LRB-
cord-006229-7yoilsho	6710	10	tissue	tissue	NN
cord-006229-7yoilsho	6710	11	culture	culture	NN
cord-006229-7yoilsho	6710	12	medium	medium	NN
cord-006229-7yoilsho	6710	13	(	(	-LRB-
cord-006229-7yoilsho	6710	14	DMEM	DMEM	NNP
cord-006229-7yoilsho	6710	15	)	)	-RRB-
cord-006229-7yoilsho	6710	16	,	,	,
cord-006229-7yoilsho	6710	17	containing	contain	VBG
cord-006229-7yoilsho	6710	18	ethanol	ethanol	NN
cord-006229-7yoilsho	6710	19	(	(	-LRB-
cord-006229-7yoilsho	6710	20	ca	ca	NNP
cord-006229-7yoilsho	6710	21	1	1	CD
cord-006229-7yoilsho	6710	22	%	%	NN
cord-006229-7yoilsho	6710	23	,	,	,
cord-006229-7yoilsho	6710	24	v	v	NN
cord-006229-7yoilsho	6710	25	/	/	SYM
cord-006229-7yoilsho	6710	26	v	v	NN
cord-006229-7yoilsho	6710	27	)	)	-RRB-
cord-006229-7yoilsho	6710	28	,	,	,
cord-006229-7yoilsho	6710	29	Uridine	Uridine	NNP
cord-006229-7yoilsho	6710	30	5'-diphosphoglucuronic	5'-diphosphoglucuronic	CD
cord-006229-7yoilsho	6710	31	acid	acid	NN
cord-006229-7yoilsho	6710	32	(	(	-LRB-
cord-006229-7yoilsho	6710	33	UDPGA	UDPGA	NNP
cord-006229-7yoilsho	6710	34	,	,	,
cord-006229-7yoilsho	6710	35	2	2	CD
cord-006229-7yoilsho	6710	36	mM	mm	CD
cord-006229-7yoilsho	6710	37	)	)	-RRB-
cord-006229-7yoilsho	6710	38	and	and	CC
cord-006229-7yoilsho	6710	39	3'-phosphoadenosine-5'-phosphosulfate	3'-phosphoadenosine-5'-phosphosulfate	CD
cord-006229-7yoilsho	6710	40	(	(	-LRB-
cord-006229-7yoilsho	6710	41	PAPS	pap	NNS
cord-006229-7yoilsho	6710	42	,	,	,
cord-006229-7yoilsho	6710	43	40	40	CD
cord-006229-7yoilsho	6710	44	µM	µm	NN
cord-006229-7yoilsho	6710	45	)	)	-RRB-
cord-006229-7yoilsho	6710	46	)	)	-RRB-
cord-006229-7yoilsho	6710	47	,	,	,
cord-006229-7yoilsho	6710	48	at	at	IN
cord-006229-7yoilsho	6710	49	multiple	multiple	JJ
cord-006229-7yoilsho	6710	50	time	time	NN
cord-006229-7yoilsho	6710	51	points	point	NNS
cord-006229-7yoilsho	6710	52	througout	througout	IN
cord-006229-7yoilsho	6710	53	the	the	DT
cord-006229-7yoilsho	6710	54	experiment	experiment	NN
cord-006229-7yoilsho	6710	55	.	.	.
cord-006229-7yoilsho	6711	1	At	at	IN
cord-006229-7yoilsho	6711	2	termination	termination	NN
cord-006229-7yoilsho	6711	3	the	the	DT
cord-006229-7yoilsho	6711	4	skin	skin	NN
cord-006229-7yoilsho	6711	5	was	be	VBD
cord-006229-7yoilsho	6711	6	removed	remove	VBN
cord-006229-7yoilsho	6711	7	from	from	IN
cord-006229-7yoilsho	6711	8	the	the	DT
cord-006229-7yoilsho	6711	9	cells	cell	NNS
cord-006229-7yoilsho	6711	10	and	and	CC
cord-006229-7yoilsho	6711	11	the	the	DT
cord-006229-7yoilsho	6711	12	stratum	stratum	NN
cord-006229-7yoilsho	6711	13	corneum	corneum	NN
cord-006229-7yoilsho	6711	14	was	be	VBD
cord-006229-7yoilsho	6711	15	removed	remove	VBN
cord-006229-7yoilsho	6711	16	with	with	IN
cord-006229-7yoilsho	6711	17	20	20	CD
cord-006229-7yoilsho	6711	18	successive	successive	JJ
cord-006229-7yoilsho	6711	19	tape	tape	NN
cord-006229-7yoilsho	6711	20	strips	strip	NNS
cord-006229-7yoilsho	6711	21	.	.	.
cord-006229-7yoilsho	6712	1	The	the	DT
cord-006229-7yoilsho	6712	2	exposed	expose	VBN
cord-006229-7yoilsho	6712	3	epidermis	epidermis	NN
cord-006229-7yoilsho	6712	4	was	be	VBD
cord-006229-7yoilsho	6712	5	separated	separate	VBN
cord-006229-7yoilsho	6712	6	from	from	IN
cord-006229-7yoilsho	6712	7	the	the	DT
cord-006229-7yoilsho	6712	8	dermis	dermis	NN
cord-006229-7yoilsho	6712	9	using	use	VBG
cord-006229-7yoilsho	6712	10	a	a	DT
cord-006229-7yoilsho	6712	11	scalpel	scalpel	NN
cord-006229-7yoilsho	6712	12	.	.	.
cord-006229-7yoilsho	6713	1	Metabolism	metabolism	NN
cord-006229-7yoilsho	6713	2	was	be	VBD
cord-006229-7yoilsho	6713	3	investigated	investigate	VBN
cord-006229-7yoilsho	6713	4	for	for	IN
cord-006229-7yoilsho	6713	5	the	the	DT
cord-006229-7yoilsho	6713	6	highest	high	JJS
cord-006229-7yoilsho	6713	7	concentration	concentration	NN
cord-006229-7yoilsho	6713	8	(	(	-LRB-
cord-006229-7yoilsho	6713	9	300	300	CD
cord-006229-7yoilsho	6713	10	mg	mg	NNP
cord-006229-7yoilsho	6713	11	BPA	BPA	NNP
cord-006229-7yoilsho	6713	12	/	/	SYM
cord-006229-7yoilsho	6713	13	L	L	NNP
cord-006229-7yoilsho	6713	14	)	)	-RRB-
cord-006229-7yoilsho	6713	15	only	only	RB
cord-006229-7yoilsho	6713	16	,	,	,
cord-006229-7yoilsho	6713	17	using	use	VBG
cord-006229-7yoilsho	6713	18	a	a	DT
cord-006229-7yoilsho	6713	19	HPLC	HPLC	NNP
cord-006229-7yoilsho	6713	20	with	with	IN
cord-006229-7yoilsho	6713	21	in	in	IN
cord-006229-7yoilsho	6713	22	-	-	HYPH
cord-006229-7yoilsho	6713	23	line	line	NN
cord-006229-7yoilsho	6713	24	radiodetection	radiodetection	NN
cord-006229-7yoilsho	6713	25	and	and	CC
cord-006229-7yoilsho	6713	26	confirmed	confirm	VBD
cord-006229-7yoilsho	6713	27	BPA	BPA	NNP
cord-006229-7yoilsho	6713	28	-	-	HYPH
cord-006229-7yoilsho	6713	29	glucuronide	glucuronide	NNP
cord-006229-7yoilsho	6713	30	(	(	-LRB-
cord-006229-7yoilsho	6713	31	BPA	BPA	NNP
cord-006229-7yoilsho	6713	32	-	-	HYPH
cord-006229-7yoilsho	6713	33	G	G	NNP
cord-006229-7yoilsho	6713	34	)	)	-RRB-
cord-006229-7yoilsho	6713	35	and	and	CC
cord-006229-7yoilsho	6713	36	BPA	bpa	NN
cord-006229-7yoilsho	6713	37	-	-	HYPH
cord-006229-7yoilsho	6713	38	sulfate	sulfate	NNP
cord-006229-7yoilsho	6713	39	(	(	-LRB-
cord-006229-7yoilsho	6713	40	BPA	BPA	NNP
cord-006229-7yoilsho	6713	41	-	-	HYPH
cord-006229-7yoilsho	6713	42	S	S	NNP
cord-006229-7yoilsho	6713	43	)	)	-RRB-
cord-006229-7yoilsho	6713	44	standards	standard	NNS
cord-006229-7yoilsho	6713	45	for	for	IN
cord-006229-7yoilsho	6713	46	comparison	comparison	NN
cord-006229-7yoilsho	6713	47	.	.	.
cord-006229-7yoilsho	6714	1	No	no	DT
cord-006229-7yoilsho	6714	2	metabolism	metabolism	NN
cord-006229-7yoilsho	6714	3	was	be	VBD
cord-006229-7yoilsho	6714	4	observed	observe	VBN
cord-006229-7yoilsho	6714	5	in	in	IN
cord-006229-7yoilsho	6714	6	any	any	DT
cord-006229-7yoilsho	6714	7	of	of	IN
cord-006229-7yoilsho	6714	8	the	the	DT
cord-006229-7yoilsho	6714	9	epidermis	epidermis	NN
cord-006229-7yoilsho	6714	10	samples	sample	NNS
cord-006229-7yoilsho	6714	11	,	,	,
cord-006229-7yoilsho	6714	12	however	however	RB
cord-006229-7yoilsho	6714	13	some	some	DT
cord-006229-7yoilsho	6714	14	metabolism	metabolism	NN
cord-006229-7yoilsho	6714	15	is	be	VBZ
cord-006229-7yoilsho	6714	16	observed	observe	VBN
cord-006229-7yoilsho	6714	17	in	in	IN
cord-006229-7yoilsho	6714	18	dermis	dermis	NN
cord-006229-7yoilsho	6714	19	and	and	CC
cord-006229-7yoilsho	6714	20	receptor	receptor	NN
cord-006229-7yoilsho	6714	21	fluid	fluid	JJ
cord-006229-7yoilsho	6714	22	samples	sample	NNS
cord-006229-7yoilsho	6714	23	.	.	.
cord-006229-7yoilsho	6715	1	Metabolites	metabolite	NNS
cord-006229-7yoilsho	6715	2	were	be	VBD
cord-006229-7yoilsho	6715	3	identified	identify	VBN
cord-006229-7yoilsho	6715	4	with	with	IN
cord-006229-7yoilsho	6715	5	retention	retention	NN
cord-006229-7yoilsho	6715	6	consistent	consistent	JJ
cord-006229-7yoilsho	6715	7	with	with	IN
cord-006229-7yoilsho	6715	8	BPA	BPA	NNP
cord-006229-7yoilsho	6715	9	-	-	HYPH
cord-006229-7yoilsho	6715	10	G	G	NNP
cord-006229-7yoilsho	6715	11	and	and	CC
cord-006229-7yoilsho	6715	12	BPA	BPA	NNP
cord-006229-7yoilsho	6715	13	-	-	HYPH
cord-006229-7yoilsho	6715	14	S	S	NNP
cord-006229-7yoilsho	6715	15	,	,	,
cord-006229-7yoilsho	6715	16	and	and	CC
cord-006229-7yoilsho	6715	17	also	also	RB
cord-006229-7yoilsho	6715	18	some	some	DT
cord-006229-7yoilsho	6715	19	more	more	RBR
cord-006229-7yoilsho	6715	20	polar	polar	JJ
cord-006229-7yoilsho	6715	21	components	component	NNS
cord-006229-7yoilsho	6715	22	.	.	.
cord-006229-7yoilsho	6716	1	The	the	DT
cord-006229-7yoilsho	6716	2	mean	mean	JJ
cord-006229-7yoilsho	6716	3	Total	Total	NNP
cord-006229-7yoilsho	6716	4	Absorbed	absorbed	JJ
cord-006229-7yoilsho	6716	5	Dose	dose	NN
cord-006229-7yoilsho	6716	6	(	(	-LRB-
cord-006229-7yoilsho	6716	7	receptor	receptor	NN
cord-006229-7yoilsho	6716	8	fluid	fluid	NN
cord-006229-7yoilsho	6716	9	+	+	CC
cord-006229-7yoilsho	6716	10	receptor	receptor	NN
cord-006229-7yoilsho	6716	11	chamber	chamber	NN
cord-006229-7yoilsho	6716	12	wash	wash	NN
cord-006229-7yoilsho	6716	13	+	+	CC
cord-006229-7yoilsho	6716	14	receptor	receptor	NN
cord-006229-7yoilsho	6716	15	rinse	rinse	NN
cord-006229-7yoilsho	6716	16	)	)	-RRB-
cord-006229-7yoilsho	6716	17	was	be	VBD
cord-006229-7yoilsho	6716	18	between	between	IN
cord-006229-7yoilsho	6716	19	1.7	1.7	CD
cord-006229-7yoilsho	6716	20	and	and	CC
cord-006229-7yoilsho	6716	21	3.6	3.6	CD
cord-006229-7yoilsho	6716	22	%	%	NN
cord-006229-7yoilsho	6716	23	of	of	IN
cord-006229-7yoilsho	6716	24	the	the	DT
cord-006229-7yoilsho	6716	25	applied	applied	JJ
cord-006229-7yoilsho	6716	26	dose	dose	NN
cord-006229-7yoilsho	6716	27	and	and	CC
cord-006229-7yoilsho	6717	1	the	the	DT
cord-006229-7yoilsho	6717	2	mean	mean	JJ
cord-006229-7yoilsho	6717	3	Dermal	dermal	JJ
cord-006229-7yoilsho	6717	4	Delivery	Delivery	NNP
cord-006229-7yoilsho	6717	5	(	(	-LRB-
cord-006229-7yoilsho	6717	6	epidermis	epidermis	NN
cord-006229-7yoilsho	6717	7	+	+	CC
cord-006229-7yoilsho	6717	8	dermis	dermis	NN
cord-006229-7yoilsho	6717	9	+	+	CC
cord-006229-7yoilsho	6717	10	total	total	NN
cord-006229-7yoilsho	6717	11	absorbed	absorb	VBN
cord-006229-7yoilsho	6717	12	dose	dose	NN
cord-006229-7yoilsho	6717	13	)	)	-RRB-
cord-006229-7yoilsho	6717	14	was	be	VBD
cord-006229-7yoilsho	6717	15	between	between	IN
cord-006229-7yoilsho	6717	16	16	16	CD
cord-006229-7yoilsho	6717	17	and	and	CC
cord-006229-7yoilsho	6717	18	20	20	CD
cord-006229-7yoilsho	6717	19	%	%	NN
cord-006229-7yoilsho	6717	20	of	of	IN
cord-006229-7yoilsho	6717	21	the	the	DT
cord-006229-7yoilsho	6717	22	applied	applied	JJ
cord-006229-7yoilsho	6717	23	dose	dose	NN
cord-006229-7yoilsho	6717	24	,	,	,
cord-006229-7yoilsho	6717	25	with	with	IN
cord-006229-7yoilsho	6717	26	the	the	DT
cord-006229-7yoilsho	6717	27	majority	majority	NN
cord-006229-7yoilsho	6717	28	of	of	IN
cord-006229-7yoilsho	6717	29	the	the	DT
cord-006229-7yoilsho	6717	30	radioactivity	radioactivity	NN
cord-006229-7yoilsho	6717	31	associated	associate	VBN
cord-006229-7yoilsho	6717	32	with	with	IN
cord-006229-7yoilsho	6717	33	epidermis	epidermis	NN
cord-006229-7yoilsho	6717	34	samples	sample	NNS
cord-006229-7yoilsho	6717	35	compared	compare	VBN
cord-006229-7yoilsho	6717	36	to	to	IN
cord-006229-7yoilsho	6717	37	dermis	dermis	NN
cord-006229-7yoilsho	6717	38	and	and	CC
cord-006229-7yoilsho	6717	39	receptor	receptor	NN
cord-006229-7yoilsho	6717	40	fluid	fluid	JJ
cord-006229-7yoilsho	6717	41	samples	sample	NNS
cord-006229-7yoilsho	6717	42	.	.	.
cord-006229-7yoilsho	6718	1	A	a	DT
cord-006229-7yoilsho	6718	2	linear	linear	JJ
cord-006229-7yoilsho	6718	3	dose	dose	JJ
cord-006229-7yoilsho	6718	4	-	-	HYPH
cord-006229-7yoilsho	6718	5	response	response	NN
cord-006229-7yoilsho	6718	6	relationship	relationship	NN
cord-006229-7yoilsho	6718	7	is	be	VBZ
cord-006229-7yoilsho	6718	8	observed	observe	VBN
cord-006229-7yoilsho	6718	9	over	over	IN
cord-006229-7yoilsho	6718	10	the	the	DT
cord-006229-7yoilsho	6718	11	whole	whole	JJ
cord-006229-7yoilsho	6718	12	concentration	concentration	NN
cord-006229-7yoilsho	6718	13	range	range	NN
cord-006229-7yoilsho	6718	14	.	.	.
cord-006229-7yoilsho	6719	1	Anastrozole	Anastrozole	NNP
cord-006229-7yoilsho	6719	2	is	be	VBZ
cord-006229-7yoilsho	6719	3	a	a	DT
cord-006229-7yoilsho	6719	4	well	well	RB
cord-006229-7yoilsho	6719	5	-	-	HYPH
cord-006229-7yoilsho	6719	6	known	know	VBN
cord-006229-7yoilsho	6719	7	non	non	JJ
cord-006229-7yoilsho	6719	8	-	-	JJ
cord-006229-7yoilsho	6719	9	steroidal	steroidal	JJ
cord-006229-7yoilsho	6719	10	aromatase	aromatase	NN
cord-006229-7yoilsho	6719	11	-	-	HYPH
cord-006229-7yoilsho	6719	12	inhibiting	inhibit	VBG
cord-006229-7yoilsho	6719	13	drug	drug	NN
cord-006229-7yoilsho	6719	14	approved	approve	VBN
cord-006229-7yoilsho	6719	15	for	for	IN
cord-006229-7yoilsho	6719	16	the	the	DT
cord-006229-7yoilsho	6719	17	second	second	JJ
cord-006229-7yoilsho	6719	18	-	-	HYPH
cord-006229-7yoilsho	6719	19	line	line	NN
cord-006229-7yoilsho	6719	20	treatment	treatment	NN
cord-006229-7yoilsho	6719	21	of	of	IN
cord-006229-7yoilsho	6719	22	breast	breast	NN
cord-006229-7yoilsho	6719	23	cancer	cancer	NN
cord-006229-7yoilsho	6719	24	after	after	IN
cord-006229-7yoilsho	6719	25	surgery	surgery	NN
cord-006229-7yoilsho	6719	26	and	and	CC
cord-006229-7yoilsho	6719	27	for	for	IN
cord-006229-7yoilsho	6719	28	treating	treat	VBG
cord-006229-7yoilsho	6719	29	postmenopausal	postmenopausal	JJ
cord-006229-7yoilsho	6719	30	women	woman	NNS
cord-006229-7yoilsho	6719	31	.	.	.
cord-006229-7yoilsho	6720	1	Treatment	treatment	NN
cord-006229-7yoilsho	6720	2	with	with	IN
cord-006229-7yoilsho	6720	3	the	the	DT
cord-006229-7yoilsho	6720	4	only	only	JJ
cord-006229-7yoilsho	6720	5	available	available	JJ
cord-006229-7yoilsho	6720	6	dosage	dosage	NN
cord-006229-7yoilsho	6720	7	form	form	NN
cord-006229-7yoilsho	6720	8	,	,	,
cord-006229-7yoilsho	6720	9	anastrozole	anastrozole	NN
cord-006229-7yoilsho	6720	10	film	film	NN
cord-006229-7yoilsho	6720	11	-	-	HYPH
cord-006229-7yoilsho	6720	12	coated	coat	VBN
cord-006229-7yoilsho	6720	13	tablets	tablet	NNS
cord-006229-7yoilsho	6720	14	for	for	IN
cord-006229-7yoilsho	6720	15	oral	oral	JJ
cord-006229-7yoilsho	6720	16	administration	administration	NN
cord-006229-7yoilsho	6720	17	,	,	,
cord-006229-7yoilsho	6720	18	is	be	VBZ
cord-006229-7yoilsho	6720	19	frequently	frequently	RB
cord-006229-7yoilsho	6720	20	associated	associate	VBN
cord-006229-7yoilsho	6720	21	with	with	IN
cord-006229-7yoilsho	6720	22	concentration	concentration	NN
cord-006229-7yoilsho	6720	23	-	-	HYPH
cord-006229-7yoilsho	6720	24	dependent	dependent	JJ
cord-006229-7yoilsho	6720	25	unwanted	unwanted	JJ
cord-006229-7yoilsho	6720	26	side	side	NN
cord-006229-7yoilsho	6720	27	effects	effect	NNS
cord-006229-7yoilsho	6720	28	like	like	IN
cord-006229-7yoilsho	6720	29	hot	hot	JJ
cord-006229-7yoilsho	6720	30	flashes	flash	NNS
cord-006229-7yoilsho	6720	31	,	,	,
cord-006229-7yoilsho	6720	32	fatigue	fatigue	NN
cord-006229-7yoilsho	6720	33	,	,	,
cord-006229-7yoilsho	6720	34	joint	joint	JJ
cord-006229-7yoilsho	6720	35	pain	pain	NN
cord-006229-7yoilsho	6720	36	,	,	,
cord-006229-7yoilsho	6720	37	joint	joint	JJ
cord-006229-7yoilsho	6720	38	stiffness	stiffness	NN
cord-006229-7yoilsho	6720	39	,	,	,
cord-006229-7yoilsho	6720	40	vaginal	vaginal	JJ
cord-006229-7yoilsho	6720	41	dryness	dryness	NN
cord-006229-7yoilsho	6720	42	,	,	,
cord-006229-7yoilsho	6720	43	hair	hair	NN
cord-006229-7yoilsho	6720	44	loss	loss	NN
cord-006229-7yoilsho	6720	45	,	,	,
cord-006229-7yoilsho	6720	46	skin	skin	NN
cord-006229-7yoilsho	6720	47	rash	rash	NN
cord-006229-7yoilsho	6720	48	,	,	,
cord-006229-7yoilsho	6720	49	nausea	nausea	NN
cord-006229-7yoilsho	6720	50	,	,	,
cord-006229-7yoilsho	6720	51	diarrhea	diarrhea	NN
cord-006229-7yoilsho	6720	52	and	and	CC
cord-006229-7yoilsho	6720	53	headache	headache	NN
cord-006229-7yoilsho	6720	54	.	.	.
cord-006229-7yoilsho	6721	1	In	in	IN
cord-006229-7yoilsho	6721	2	order	order	NN
cord-006229-7yoilsho	6721	3	to	to	TO
cord-006229-7yoilsho	6721	4	minimize	minimize	VB
cord-006229-7yoilsho	6721	5	the	the	DT
cord-006229-7yoilsho	6721	6	local	local	JJ
cord-006229-7yoilsho	6721	7	gastrointestinal	gastrointestinal	JJ
cord-006229-7yoilsho	6721	8	as	as	RB
cord-006229-7yoilsho	6721	9	well	well	RB
cord-006229-7yoilsho	6721	10	as	as	IN
cord-006229-7yoilsho	6721	11	systemic	systemic	JJ
cord-006229-7yoilsho	6721	12	side	side	NN
cord-006229-7yoilsho	6721	13	effects	effect	NNS
cord-006229-7yoilsho	6721	14	,	,	,
cord-006229-7yoilsho	6721	15	a	a	DT
cord-006229-7yoilsho	6721	16	system	system	NN
cord-006229-7yoilsho	6721	17	for	for	IN
cord-006229-7yoilsho	6721	18	transdermal	transdermal	JJ
cord-006229-7yoilsho	6721	19	anastrozole	anastrozole	NN
cord-006229-7yoilsho	6721	20	delivery	delivery	NN
cord-006229-7yoilsho	6721	21	has	have	VBZ
cord-006229-7yoilsho	6721	22	recently	recently	RB
cord-006229-7yoilsho	6721	23	been	be	VBN
cord-006229-7yoilsho	6721	24	developed	develop	VBN
cord-006229-7yoilsho	6721	25	.	.	.
cord-006229-7yoilsho	6722	1	In	in	IN
cord-006229-7yoilsho	6722	2	this	this	DT
cord-006229-7yoilsho	6722	3	study	study	NN
cord-006229-7yoilsho	6722	4	,	,	,
cord-006229-7yoilsho	6722	5	we	-PRON-	PRP
cord-006229-7yoilsho	6722	6	describe	describe	VBP
cord-006229-7yoilsho	6722	7	the	the	DT
cord-006229-7yoilsho	6722	8	first	first	JJ
cord-006229-7yoilsho	6722	9	experimental	experimental	NN
cord-006229-7yoilsho	6722	10	in	in	IN
cord-006229-7yoilsho	6722	11	vivo	vivo	NN
cord-006229-7yoilsho	6722	12	application	application	NN
cord-006229-7yoilsho	6722	13	of	of	IN
cord-006229-7yoilsho	6722	14	a	a	DT
cord-006229-7yoilsho	6722	15	transdermal	transdermal	JJ
cord-006229-7yoilsho	6722	16	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	6722	17	system	system	NN
cord-006229-7yoilsho	6722	18	(	(	-LRB-
cord-006229-7yoilsho	6722	19	TTS	TTS	NNP
cord-006229-7yoilsho	6722	20	)	)	-RRB-
cord-006229-7yoilsho	6722	21	to	to	IN
cord-006229-7yoilsho	6722	22	Beagle	Beagle	NNP
cord-006229-7yoilsho	6722	23	dogs	dog	NNS
cord-006229-7yoilsho	6722	24	and	and	CC
cord-006229-7yoilsho	6722	25	,	,	,
cord-006229-7yoilsho	6722	26	as	as	IN
cord-006229-7yoilsho	6722	27	a	a	DT
cord-006229-7yoilsho	6722	28	necessary	necessary	JJ
cord-006229-7yoilsho	6722	29	prerequisite	prerequisite	NN
cord-006229-7yoilsho	6722	30	for	for	IN
cord-006229-7yoilsho	6722	31	the	the	DT
cord-006229-7yoilsho	6722	32	analysis	analysis	NN
cord-006229-7yoilsho	6722	33	of	of	IN
cord-006229-7yoilsho	6722	34	the	the	DT
cord-006229-7yoilsho	6722	35	time	time	NN
cord-006229-7yoilsho	6722	36	course	course	NN
cord-006229-7yoilsho	6722	37	of	of	IN
cord-006229-7yoilsho	6722	38	anastrozole	anastrozole	NN
cord-006229-7yoilsho	6722	39	release	release	NN
cord-006229-7yoilsho	6722	40	and	and	CC
cord-006229-7yoilsho	6722	41	uptake	uptake	NN
cord-006229-7yoilsho	6722	42	,	,	,
cord-006229-7yoilsho	6722	43	a	a	DT
cord-006229-7yoilsho	6722	44	simple	simple	JJ
cord-006229-7yoilsho	6722	45	,	,	,
cord-006229-7yoilsho	6722	46	sensitive	sensitive	JJ
cord-006229-7yoilsho	6722	47	and	and	CC
cord-006229-7yoilsho	6722	48	accurate	accurate	JJ
cord-006229-7yoilsho	6722	49	LC	LC	NNP
cord-006229-7yoilsho	6722	50	-	-	HYPH
cord-006229-7yoilsho	6722	51	MS	MS	NNP
cord-006229-7yoilsho	6722	52	method	method	NN
cord-006229-7yoilsho	6722	53	for	for	IN
cord-006229-7yoilsho	6722	54	quantifying	quantify	VBG
cord-006229-7yoilsho	6722	55	anastrozole	anastrozole	NN
cord-006229-7yoilsho	6722	56	in	in	IN
cord-006229-7yoilsho	6722	57	plasma	plasma	NN
cord-006229-7yoilsho	6722	58	.	.	.
cord-006229-7yoilsho	6723	1	The	the	DT
cord-006229-7yoilsho	6723	2	detection	detection	NN
cord-006229-7yoilsho	6723	3	of	of	IN
cord-006229-7yoilsho	6723	4	fragment	fragment	NN
cord-006229-7yoilsho	6723	5	ions	ion	NNS
cord-006229-7yoilsho	6723	6	at	at	IN
cord-006229-7yoilsho	6723	7	m	m	NNP
cord-006229-7yoilsho	6723	8	/	/	SYM
cord-006229-7yoilsho	6723	9	z	z	NNP
cord-006229-7yoilsho	6723	10	225	225	CD
cord-006229-7yoilsho	6723	11	and	and	CC
cord-006229-7yoilsho	6723	12	237	237	CD
cord-006229-7yoilsho	6723	13	instead	instead	RB
cord-006229-7yoilsho	6723	14	of	of	IN
cord-006229-7yoilsho	6723	15	the	the	DT
cord-006229-7yoilsho	6723	16	molecule	molecule	NN
cord-006229-7yoilsho	6723	17	ions	ion	NNS
cord-006229-7yoilsho	6723	18	(	(	-LRB-
cord-006229-7yoilsho	6723	19	m	m	NNP
cord-006229-7yoilsho	6723	20	/	/	SYM
cord-006229-7yoilsho	6723	21	z	z	NNP
cord-006229-7yoilsho	6723	22	294	294	CD
cord-006229-7yoilsho	6723	23	and	and	CC
cord-006229-7yoilsho	6723	24	306	306	CD
cord-006229-7yoilsho	6723	25	)	)	-RRB-
cord-006229-7yoilsho	6723	26	generated	generate	VBN
cord-006229-7yoilsho	6723	27	from	from	IN
cord-006229-7yoilsho	6723	28	the	the	DT
cord-006229-7yoilsho	6723	29	elevated	elevated	JJ
cord-006229-7yoilsho	6723	30	collision	collision	NN
cord-006229-7yoilsho	6723	31	energy	energy	NN
cord-006229-7yoilsho	6723	32	,	,	,
cord-006229-7yoilsho	6723	33	and	and	CC
cord-006229-7yoilsho	6723	34	the	the	DT
cord-006229-7yoilsho	6723	35	use	use	NN
cord-006229-7yoilsho	6723	36	of	of	IN
cord-006229-7yoilsho	6723	37	a	a	DT
cord-006229-7yoilsho	6723	38	deuterated	deuterated	JJ
cord-006229-7yoilsho	6723	39	internal	internal	JJ
cord-006229-7yoilsho	6723	40	standard	standard	NN
cord-006229-7yoilsho	6723	41	resulted	result	VBD
cord-006229-7yoilsho	6723	42	in	in	IN
cord-006229-7yoilsho	6723	43	increased	increase	VBN
cord-006229-7yoilsho	6723	44	relative	relative	JJ
cord-006229-7yoilsho	6723	45	abundances	abundance	NNS
cord-006229-7yoilsho	6723	46	and	and	CC
cord-006229-7yoilsho	6723	47	improved	improved	JJ
cord-006229-7yoilsho	6723	48	signal	signal	NN
cord-006229-7yoilsho	6723	49	-	-	HYPH
cord-006229-7yoilsho	6723	50	to	to	IN
cord-006229-7yoilsho	6723	51	-	-	HYPH
cord-006229-7yoilsho	6723	52	noise	noise	NN
cord-006229-7yoilsho	6723	53	ratios	ratio	NNS
cord-006229-7yoilsho	6723	54	.	.	.
cord-006229-7yoilsho	6724	1	The	the	DT
cord-006229-7yoilsho	6724	2	lower	low	JJR
cord-006229-7yoilsho	6724	3	limit	limit	NN
cord-006229-7yoilsho	6724	4	of	of	IN
cord-006229-7yoilsho	6724	5	quantification	quantification	NN
cord-006229-7yoilsho	6724	6	and	and	CC
cord-006229-7yoilsho	6724	7	the	the	DT
cord-006229-7yoilsho	6724	8	limit	limit	NN
cord-006229-7yoilsho	6724	9	of	of	IN
cord-006229-7yoilsho	6724	10	detection	detection	NN
cord-006229-7yoilsho	6724	11	were	be	VBD
cord-006229-7yoilsho	6724	12	1.4	1.4	CD
cord-006229-7yoilsho	6724	13	ng	ng	NNP
cord-006229-7yoilsho	6724	14	/	/	SYM
cord-006229-7yoilsho	6724	15	ml	ml	NN
cord-006229-7yoilsho	6724	16	and	and	CC
cord-006229-7yoilsho	6724	17	0.5	0.5	CD
cord-006229-7yoilsho	6724	18	ng	ng	NN
cord-006229-7yoilsho	6724	19	/	/	SYM
cord-006229-7yoilsho	6724	20	ml	ml	NNS
cord-006229-7yoilsho	6724	21	,	,	,
cord-006229-7yoilsho	6724	22	respectively	respectively	RB
cord-006229-7yoilsho	6724	23	.	.	.
cord-006229-7yoilsho	6725	1	The	the	DT
cord-006229-7yoilsho	6725	2	developed	developed	JJ
cord-006229-7yoilsho	6725	3	method	method	NN
cord-006229-7yoilsho	6725	4	was	be	VBD
cord-006229-7yoilsho	6725	5	successfully	successfully	RB
cord-006229-7yoilsho	6725	6	applied	apply	VBN
cord-006229-7yoilsho	6725	7	in	in	IN
cord-006229-7yoilsho	6725	8	a	a	DT
cord-006229-7yoilsho	6725	9	pharmacokinetic	pharmacokinetic	JJ
cord-006229-7yoilsho	6725	10	study	study	NN
cord-006229-7yoilsho	6725	11	of	of	IN
cord-006229-7yoilsho	6725	12	anastrozole	anastrozole	NN
cord-006229-7yoilsho	6725	13	plasma	plasma	NN
cord-006229-7yoilsho	6725	14	levels	level	NNS
cord-006229-7yoilsho	6725	15	in	in	IN
cord-006229-7yoilsho	6725	16	beagle	beagle	NN
cord-006229-7yoilsho	6725	17	dogs	dog	NNS
cord-006229-7yoilsho	6725	18	,	,	,
cord-006229-7yoilsho	6725	19	measuring	measure	VBG
cord-006229-7yoilsho	6725	20	percutaneous	percutaneous	JJ
cord-006229-7yoilsho	6725	21	drug	drug	NN
cord-006229-7yoilsho	6725	22	absorption	absorption	NN
cord-006229-7yoilsho	6725	23	from	from	IN
cord-006229-7yoilsho	6725	24	an	an	DT
cord-006229-7yoilsho	6725	25	experimental	experimental	JJ
cord-006229-7yoilsho	6725	26	,	,	,
cord-006229-7yoilsho	6725	27	newly	newly	RB
cord-006229-7yoilsho	6725	28	designed	design	VBN
cord-006229-7yoilsho	6725	29	glycerol	glycerol	NN
cord-006229-7yoilsho	6725	30	-	-	HYPH
cord-006229-7yoilsho	6725	31	based	base	VBN
cord-006229-7yoilsho	6725	32	patch	patch	NN
cord-006229-7yoilsho	6725	33	/	/	SYM
cord-006229-7yoilsho	6725	34	TTS	TTS	NNP
cord-006229-7yoilsho	6725	35	.	.	.
cord-006229-7yoilsho	6726	1	A	a	DT
cord-006229-7yoilsho	6726	2	distinct	distinct	JJ
cord-006229-7yoilsho	6726	3	time	time	NN
cord-006229-7yoilsho	6726	4	course	course	NN
cord-006229-7yoilsho	6726	5	was	be	VBD
cord-006229-7yoilsho	6726	6	observed	observe	VBN
cord-006229-7yoilsho	6726	7	,	,	,
cord-006229-7yoilsho	6726	8	with	with	IN
cord-006229-7yoilsho	6726	9	an	an	DT
cord-006229-7yoilsho	6726	10	initial	initial	JJ
cord-006229-7yoilsho	6726	11	linear	linear	JJ
cord-006229-7yoilsho	6726	12	increase	increase	NN
cord-006229-7yoilsho	6726	13	over	over	IN
cord-006229-7yoilsho	6726	14	24	24	CD
cord-006229-7yoilsho	6726	15	hours	hour	NNS
cord-006229-7yoilsho	6726	16	and	and	CC
cord-006229-7yoilsho	6726	17	a	a	DT
cord-006229-7yoilsho	6726	18	plateau	plateau	NN
cord-006229-7yoilsho	6726	19	thereafter	thereafter	RB
cord-006229-7yoilsho	6726	20	.	.	.
cord-006229-7yoilsho	6727	1	This	this	DT
cord-006229-7yoilsho	6727	2	offers	offer	VBZ
cord-006229-7yoilsho	6727	3	promising	promising	JJ
cord-006229-7yoilsho	6727	4	strategies	strategy	NNS
cord-006229-7yoilsho	6727	5	for	for	IN
cord-006229-7yoilsho	6727	6	the	the	DT
cord-006229-7yoilsho	6727	7	transdermal	transdermal	JJ
cord-006229-7yoilsho	6727	8	application	application	NN
cord-006229-7yoilsho	6727	9	of	of	IN
cord-006229-7yoilsho	6727	10	anastrozole	anastrozole	NN
cord-006229-7yoilsho	6727	11	with	with	IN
cord-006229-7yoilsho	6727	12	improved	improved	JJ
cord-006229-7yoilsho	6727	13	pharmacokinetics	pharmacokinetic	NNS
cord-006229-7yoilsho	6727	14	.	.	.
cord-006229-7yoilsho	6728	1	Background	background	NN
cord-006229-7yoilsho	6728	2	:	:	:
cord-006229-7yoilsho	6729	1	The	the	DT
cord-006229-7yoilsho	6729	2	monocarboxylate	monocarboxylate	NN
cord-006229-7yoilsho	6729	3	transporter	transporter	NN
cord-006229-7yoilsho	6729	4	4	4	CD
cord-006229-7yoilsho	6729	5	(	(	-LRB-
cord-006229-7yoilsho	6729	6	MCT4	MCT4	NNP
cord-006229-7yoilsho	6729	7	)	)	-RRB-
cord-006229-7yoilsho	6729	8	,	,	,
cord-006229-7yoilsho	6729	9	encoded	encode	VBN
cord-006229-7yoilsho	6729	10	by	by	IN
cord-006229-7yoilsho	6729	11	the	the	DT
cord-006229-7yoilsho	6729	12	SLC16A3	slc16a3	NN
cord-006229-7yoilsho	6729	13	gene	gene	NN
cord-006229-7yoilsho	6729	14	,	,	,
cord-006229-7yoilsho	6729	15	mediates	mediate	VBZ
cord-006229-7yoilsho	6729	16	H	h	NN
cord-006229-7yoilsho	6729	17	+	+	CC
cord-006229-7yoilsho	6729	18	-coupled	-coupled	JJ
cord-006229-7yoilsho	6729	19	transport	transport	NN
cord-006229-7yoilsho	6729	20	of	of	IN
cord-006229-7yoilsho	6729	21	lactate	lactate	NN
cord-006229-7yoilsho	6729	22	across	across	IN
cord-006229-7yoilsho	6729	23	the	the	DT
cord-006229-7yoilsho	6729	24	plasma	plasma	NN
cord-006229-7yoilsho	6729	25	membrane	membrane	NN
cord-006229-7yoilsho	6729	26	.	.	.
cord-006229-7yoilsho	6730	1	For	for	IN
cord-006229-7yoilsho	6730	2	cells	cell	NNS
cord-006229-7yoilsho	6730	3	with	with	IN
cord-006229-7yoilsho	6730	4	high	high	JJ
cord-006229-7yoilsho	6730	5	glycolytic	glycolytic	JJ
cord-006229-7yoilsho	6730	6	activity	activity	NN
cord-006229-7yoilsho	6730	7	lactate	lactate	NN
cord-006229-7yoilsho	6730	8	export	export	NN
cord-006229-7yoilsho	6730	9	is	be	VBZ
cord-006229-7yoilsho	6730	10	of	of	IN
cord-006229-7yoilsho	6730	11	major	major	JJ
cord-006229-7yoilsho	6730	12	importance	importance	NN
cord-006229-7yoilsho	6730	13	for	for	IN
cord-006229-7yoilsho	6730	14	the	the	DT
cord-006229-7yoilsho	6730	15	maintenance	maintenance	NN
cord-006229-7yoilsho	6730	16	of	of	IN
cord-006229-7yoilsho	6730	17	the	the	DT
cord-006229-7yoilsho	6730	18	glycolytic	glycolytic	JJ
cord-006229-7yoilsho	6730	19	metabolism	metabolism	NN
cord-006229-7yoilsho	6730	20	and	and	CC
cord-006229-7yoilsho	6730	21	for	for	IN
cord-006229-7yoilsho	6730	22	the	the	DT
cord-006229-7yoilsho	6730	23	prevention	prevention	NN
cord-006229-7yoilsho	6730	24	of	of	IN
cord-006229-7yoilsho	6730	25	intracellular	intracellular	JJ
cord-006229-7yoilsho	6730	26	acidification	acidification	NN
cord-006229-7yoilsho	6730	27	.	.	.
cord-006229-7yoilsho	6731	1	In	in	IN
cord-006229-7yoilsho	6731	2	glycolytic	glycolytic	JJ
cord-006229-7yoilsho	6731	3	tumor	tumor	NN
cord-006229-7yoilsho	6731	4	cells	cell	NNS
cord-006229-7yoilsho	6731	5	,	,	,
cord-006229-7yoilsho	6731	6	the	the	DT
cord-006229-7yoilsho	6731	7	acidic	acidic	JJ
cord-006229-7yoilsho	6731	8	extracellular	extracellular	JJ
cord-006229-7yoilsho	6731	9	environment	environment	NN
cord-006229-7yoilsho	6731	10	resulting	result	VBG
cord-006229-7yoilsho	6731	11	from	from	IN
cord-006229-7yoilsho	6731	12	export	export	NN
cord-006229-7yoilsho	6731	13	of	of	IN
cord-006229-7yoilsho	6731	14	lactate	lactate	NN
cord-006229-7yoilsho	6731	15	and	and	CC
cord-006229-7yoilsho	6731	16	H	h	NN
cord-006229-7yoilsho	6731	17	+	+	CC
cord-006229-7yoilsho	6731	18	,	,	,
cord-006229-7yoilsho	6731	19	furthermore	furthermore	RB
cord-006229-7yoilsho	6731	20	promotes	promote	VBZ
cord-006229-7yoilsho	6731	21	anti	anti	JJ
cord-006229-7yoilsho	6731	22	-	-	JJ
cord-006229-7yoilsho	6731	23	apoptotic	apoptotic	JJ
cord-006229-7yoilsho	6731	24	effects	effect	NNS
cord-006229-7yoilsho	6731	25	and	and	CC
cord-006229-7yoilsho	6731	26	metastasis	metastasis	NN
cord-006229-7yoilsho	6731	27	.	.	.
cord-006229-7yoilsho	6732	1	Clear	clear	JJ
cord-006229-7yoilsho	6732	2	cell	cell	NN
cord-006229-7yoilsho	6732	3	renal	renal	JJ
cord-006229-7yoilsho	6732	4	cell	cell	NN
cord-006229-7yoilsho	6732	5	carcinoma	carcinoma	NN
cord-006229-7yoilsho	6732	6	(	(	-LRB-
cord-006229-7yoilsho	6732	7	ccRCC	ccrcc	NN
cord-006229-7yoilsho	6732	8	)	)	-RRB-
cord-006229-7yoilsho	6732	9	is	be	VBZ
cord-006229-7yoilsho	6732	10	the	the	DT
cord-006229-7yoilsho	6732	11	most	most	RBS
cord-006229-7yoilsho	6732	12	common	common	JJ
cord-006229-7yoilsho	6732	13	subtype	subtype	NN
cord-006229-7yoilsho	6732	14	of	of	IN
cord-006229-7yoilsho	6732	15	renal	renal	JJ
cord-006229-7yoilsho	6732	16	cell	cell	NN
cord-006229-7yoilsho	6732	17	carcinoma	carcinoma	NN
cord-006229-7yoilsho	6732	18	(	(	-LRB-
cord-006229-7yoilsho	6732	19	RCC	RCC	NNP
cord-006229-7yoilsho	6732	20	)	)	-RRB-
cord-006229-7yoilsho	6732	21	and	and	CC
cord-006229-7yoilsho	6732	22	is	be	VBZ
cord-006229-7yoilsho	6732	23	characterized	characterize	VBN
cord-006229-7yoilsho	6732	24	by	by	IN
cord-006229-7yoilsho	6732	25	a	a	DT
cord-006229-7yoilsho	6732	26	metabolic	metabolic	JJ
cord-006229-7yoilsho	6732	27	shift	shift	NN
cord-006229-7yoilsho	6732	28	towards	towards	IN
cord-006229-7yoilsho	6732	29	enhanced	enhanced	JJ
cord-006229-7yoilsho	6732	30	aerobic	aerobic	JJ
cord-006229-7yoilsho	6732	31	glycolysis	glycolysis	NN
cord-006229-7yoilsho	6732	32	and	and	CC
cord-006229-7yoilsho	6732	33	hence	hence	RB
cord-006229-7yoilsho	6732	34	,	,	,
cord-006229-7yoilsho	6732	35	increased	increase	VBN
cord-006229-7yoilsho	6732	36	lactate	lactate	NN
cord-006229-7yoilsho	6732	37	production	production	NN
cord-006229-7yoilsho	6732	38	.	.	.
cord-006229-7yoilsho	6733	1	MCT4	MCT4	NNS
cord-006229-7yoilsho	6733	2	and	and	CC
cord-006229-7yoilsho	6733	3	its	-PRON-	PRP$
cord-006229-7yoilsho	6733	4	epigenetic	epigenetic	JJ
cord-006229-7yoilsho	6733	5	regulation	regulation	NN
cord-006229-7yoilsho	6733	6	by	by	IN
cord-006229-7yoilsho	6733	7	SLC16A3	slc16a3	NN
cord-006229-7yoilsho	6733	8	promoter	promoter	NN
cord-006229-7yoilsho	6733	9	methylation	methylation	NN
cord-006229-7yoilsho	6733	10	has	have	VBZ
cord-006229-7yoilsho	6733	11	previously	previously	RB
cord-006229-7yoilsho	6733	12	been	be	VBN
cord-006229-7yoilsho	6733	13	identified	identify	VBN
cord-006229-7yoilsho	6733	14	as	as	IN
cord-006229-7yoilsho	6733	15	prognostic	prognostic	JJ
cord-006229-7yoilsho	6733	16	marker	marker	NN
cord-006229-7yoilsho	6733	17	for	for	IN
cord-006229-7yoilsho	6733	18	ccRCC	ccrcc	NN
cord-006229-7yoilsho	6733	19	outcome	outcome	NN
cord-006229-7yoilsho	6733	20	and	and	CC
cord-006229-7yoilsho	6733	21	as	as	IN
cord-006229-7yoilsho	6733	22	target	target	NN
cord-006229-7yoilsho	6733	23	for	for	IN
cord-006229-7yoilsho	6733	24	ccRCC	ccrcc	NN
cord-006229-7yoilsho	6733	25	treatment	treatment	NN
cord-006229-7yoilsho	6733	26	.	.	.
cord-006229-7yoilsho	6734	1	Since	since	IN
cord-006229-7yoilsho	6734	2	metastatic	metastatic	JJ
cord-006229-7yoilsho	6734	3	ccRCC	ccrcc	NN
cord-006229-7yoilsho	6734	4	is	be	VBZ
cord-006229-7yoilsho	6734	5	associated	associate	VBN
cord-006229-7yoilsho	6734	6	with	with	IN
cord-006229-7yoilsho	6734	7	poor	poor	JJ
cord-006229-7yoilsho	6734	8	overall	overall	JJ
cord-006229-7yoilsho	6734	9	survival	survival	NN
cord-006229-7yoilsho	6734	10	and	and	CC
cord-006229-7yoilsho	6734	11	represents	represent	VBZ
cord-006229-7yoilsho	6734	12	a	a	DT
cord-006229-7yoilsho	6734	13	major	major	JJ
cord-006229-7yoilsho	6734	14	challenge	challenge	NN
cord-006229-7yoilsho	6734	15	for	for	IN
cord-006229-7yoilsho	6734	16	treatment	treatment	NN
cord-006229-7yoilsho	6734	17	,	,	,
cord-006229-7yoilsho	6734	18	MCT4	MCT4	NNP
cord-006229-7yoilsho	6734	19	/	/	SYM
cord-006229-7yoilsho	6734	20	SLC16A3	SLC16A3	NNP
cord-006229-7yoilsho	6734	21	might	may	MD
cord-006229-7yoilsho	6734	22	represent	represent	VB
cord-006229-7yoilsho	6734	23	a	a	DT
cord-006229-7yoilsho	6734	24	promising	promising	JJ
cord-006229-7yoilsho	6734	25	prognostic	prognostic	JJ
cord-006229-7yoilsho	6734	26	marker	marker	NN
cord-006229-7yoilsho	6734	27	and	and	CC
cord-006229-7yoilsho	6734	28	a	a	DT
cord-006229-7yoilsho	6734	29	target	target	NN
cord-006229-7yoilsho	6734	30	for	for	IN
cord-006229-7yoilsho	6734	31	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	6734	32	intervention	intervention	NN
cord-006229-7yoilsho	6734	33	also	also	RB
cord-006229-7yoilsho	6734	34	for	for	IN
cord-006229-7yoilsho	6734	35	metastatic	metastatic	JJ
cord-006229-7yoilsho	6734	36	disease	disease	NN
cord-006229-7yoilsho	6734	37	.	.	.
cord-006229-7yoilsho	6735	1	Methods	method	NNS
cord-006229-7yoilsho	6735	2	:	:	:
cord-006229-7yoilsho	6736	1	MCT4	mct4	JJ
cord-006229-7yoilsho	6736	2	protein	protein	NN
cord-006229-7yoilsho	6736	3	expression	expression	NN
cord-006229-7yoilsho	6736	4	was	be	VBD
cord-006229-7yoilsho	6736	5	analysed	analyse	VBN
cord-006229-7yoilsho	6736	6	in	in	IN
cord-006229-7yoilsho	6736	7	130	130	CD
cord-006229-7yoilsho	6736	8	paraffin	paraffin	NN
cord-006229-7yoilsho	6736	9	embedded	embed	VBN
cord-006229-7yoilsho	6736	10	tissue	tissue	NN
cord-006229-7yoilsho	6736	11	samples	sample	NNS
cord-006229-7yoilsho	6736	12	of	of	IN
cord-006229-7yoilsho	6736	13	distant	distant	JJ
cord-006229-7yoilsho	6736	14	metastases	metastasis	NNS
cord-006229-7yoilsho	6736	15	derived	derive	VBN
cord-006229-7yoilsho	6736	16	from	from	IN
cord-006229-7yoilsho	6736	17	different	different	JJ
cord-006229-7yoilsho	6736	18	organs	organ	NNS
cord-006229-7yoilsho	6736	19	by	by	IN
cord-006229-7yoilsho	6736	20	immunohistochemical	immunohistochemical	JJ
cord-006229-7yoilsho	6736	21	staining	staining	NN
cord-006229-7yoilsho	6736	22	of	of	IN
cord-006229-7yoilsho	6736	23	tissue	tissue	NN
cord-006229-7yoilsho	6736	24	microarrays	microarray	NNS
cord-006229-7yoilsho	6736	25	.	.	.
cord-006229-7yoilsho	6737	1	Protein	protein	NN
cord-006229-7yoilsho	6737	2	expression	expression	NN
cord-006229-7yoilsho	6737	3	was	be	VBD
cord-006229-7yoilsho	6737	4	evaluated	evaluate	VBN
cord-006229-7yoilsho	6737	5	semi	semi	RB
cord-006229-7yoilsho	6737	6	-	-	JJ
cord-006229-7yoilsho	6737	7	quantitatively	quantitatively	RB
cord-006229-7yoilsho	6737	8	using	use	VBG
cord-006229-7yoilsho	6737	9	Tissue	Tissue	NNP
cord-006229-7yoilsho	6737	10	Studio	Studio	NNP
cord-006229-7yoilsho	6737	11	v.3.6	v.3.6	.
cord-006229-7yoilsho	6738	1	(	(	-LRB-
cord-006229-7yoilsho	6738	2	Definiens	Definiens	NNP
cord-006229-7yoilsho	6738	3	AG	AG	NNP
cord-006229-7yoilsho	6738	4	)	)	-RRB-
cord-006229-7yoilsho	6738	5	.	.	.
cord-006229-7yoilsho	6739	1	DNA	dna	NN
cord-006229-7yoilsho	6739	2	methylation	methylation	NN
cord-006229-7yoilsho	6739	3	in	in	IN
cord-006229-7yoilsho	6739	4	the	the	DT
cord-006229-7yoilsho	6739	5	SLC16A3	slc16a3	NN
cord-006229-7yoilsho	6739	6	promoter	promoter	NN
cord-006229-7yoilsho	6739	7	,	,	,
cord-006229-7yoilsho	6739	8	specifically	specifically	RB
cord-006229-7yoilsho	6739	9	at	at	IN
cord-006229-7yoilsho	6739	10	the	the	DT
cord-006229-7yoilsho	6739	11	previously	previously	RB
cord-006229-7yoilsho	6739	12	identified	identify	VBN
cord-006229-7yoilsho	6739	13	CpG	CpG	NNP
cord-006229-7yoilsho	6739	14	site	site	NN
cord-006229-7yoilsho	6739	15	with	with	IN
cord-006229-7yoilsho	6739	16	prognostic	prognostic	JJ
cord-006229-7yoilsho	6739	17	potential	potential	NN
cord-006229-7yoilsho	6739	18	in	in	IN
cord-006229-7yoilsho	6739	19	primary	primary	JJ
cord-006229-7yoilsho	6739	20	ccRCC	ccrcc	NN
cord-006229-7yoilsho	6739	21	,	,	,
cord-006229-7yoilsho	6739	22	was	be	VBD
cord-006229-7yoilsho	6739	23	analysed	analyse	VBN
cord-006229-7yoilsho	6739	24	in	in	IN
cord-006229-7yoilsho	6739	25	82	82	CD
cord-006229-7yoilsho	6739	26	paraffin	paraffin	NN
cord-006229-7yoilsho	6739	27	embedded	embed	VBN
cord-006229-7yoilsho	6739	28	metastasis	metastasis	NN
cord-006229-7yoilsho	6739	29	samples	sample	NNS
cord-006229-7yoilsho	6739	30	by	by	IN
cord-006229-7yoilsho	6739	31	MALDI	MALDI	NNP
cord-006229-7yoilsho	6739	32	TOF	TOF	NNP
cord-006229-7yoilsho	6739	33	-	-	HYPH
cord-006229-7yoilsho	6739	34	MS	MS	NNP
cord-006229-7yoilsho	6739	35	.	.	.
cord-006229-7yoilsho	6740	1	MCT4	mct4	JJ
cord-006229-7yoilsho	6740	2	protein	protein	NN
cord-006229-7yoilsho	6740	3	expression	expression	NN
cord-006229-7yoilsho	6740	4	data	datum	NNS
cord-006229-7yoilsho	6740	5	and	and	CC
cord-006229-7yoilsho	6740	6	DNA	dna	NN
cord-006229-7yoilsho	6740	7	methylation	methylation	NN
cord-006229-7yoilsho	6740	8	at	at	IN
cord-006229-7yoilsho	6740	9	the	the	DT
cord-006229-7yoilsho	6740	10	specific	specific	JJ
cord-006229-7yoilsho	6740	11	CpG	cpg	NN
cord-006229-7yoilsho	6740	12	site	site	NN
cord-006229-7yoilsho	6740	13	in	in	IN
cord-006229-7yoilsho	6740	14	the	the	DT
cord-006229-7yoilsho	6740	15	SLC16A3	slc16a3	NN
cord-006229-7yoilsho	6740	16	promoter	promoter	NN
cord-006229-7yoilsho	6740	17	were	be	VBD
cord-006229-7yoilsho	6740	18	correlated	correlate	VBN
cord-006229-7yoilsho	6740	19	with	with	IN
cord-006229-7yoilsho	6740	20	clinicopathological	clinicopathological	JJ
cord-006229-7yoilsho	6740	21	parameters	parameter	NNS
cord-006229-7yoilsho	6740	22	and	and	CC
cord-006229-7yoilsho	6740	23	outcome	outcome	NN
cord-006229-7yoilsho	6740	24	data	datum	NNS
cord-006229-7yoilsho	6740	25	.	.	.
cord-006229-7yoilsho	6741	1	Results	result	NNS
cord-006229-7yoilsho	6741	2	:	:	:
cord-006229-7yoilsho	6742	1	Distant	distant	JJ
cord-006229-7yoilsho	6742	2	metastases	metastasis	NNS
cord-006229-7yoilsho	6742	3	of	of	IN
cord-006229-7yoilsho	6742	4	primary	primary	NN
cord-006229-7yoilsho	6742	5	ccRCC	ccrcc	NN
cord-006229-7yoilsho	6743	1	showed	show	VBD
cord-006229-7yoilsho	6743	2	high	high	JJ
cord-006229-7yoilsho	6743	3	MCT4	MCT4	NNP
cord-006229-7yoilsho	6743	4	protein	protein	NN
cord-006229-7yoilsho	6743	5	expression	expression	NN
cord-006229-7yoilsho	6743	6	irrespective	irrespective	RB
cord-006229-7yoilsho	6743	7	of	of	IN
cord-006229-7yoilsho	6743	8	the	the	DT
cord-006229-7yoilsho	6743	9	affected	affected	JJ
cord-006229-7yoilsho	6743	10	organ	organ	NN
cord-006229-7yoilsho	6743	11	.	.	.
cord-006229-7yoilsho	6744	1	The	the	DT
cord-006229-7yoilsho	6744	2	most	most	RBS
cord-006229-7yoilsho	6744	3	frequently	frequently	RB
cord-006229-7yoilsho	6744	4	affected	affect	VBN
cord-006229-7yoilsho	6744	5	organs	organ	NNS
cord-006229-7yoilsho	6744	6	like	like	IN
cord-006229-7yoilsho	6744	7	lung	lung	NN
cord-006229-7yoilsho	6744	8	or	or	CC
cord-006229-7yoilsho	6744	9	bone	bone	NN
cord-006229-7yoilsho	6744	10	,	,	,
cord-006229-7yoilsho	6744	11	with	with	IN
cord-006229-7yoilsho	6744	12	approximately	approximately	RB
cord-006229-7yoilsho	6744	13	28	28	CD
cord-006229-7yoilsho	6744	14	%	%	NN
cord-006229-7yoilsho	6744	15	and	and	CC
cord-006229-7yoilsho	6744	16	14	14	CD
cord-006229-7yoilsho	6744	17	%	%	NN
cord-006229-7yoilsho	6744	18	in	in	IN
cord-006229-7yoilsho	6744	19	our	-PRON-	PRP$
cord-006229-7yoilsho	6744	20	cohort	cohort	NN
cord-006229-7yoilsho	6744	21	respectively	respectively	RB
cord-006229-7yoilsho	6744	22	,	,	,
cord-006229-7yoilsho	6744	23	showed	show	VBD
cord-006229-7yoilsho	6744	24	similar	similar	JJ
cord-006229-7yoilsho	6744	25	expression	expression	NN
cord-006229-7yoilsho	6744	26	levels	level	NNS
cord-006229-7yoilsho	6744	27	as	as	IN
cord-006229-7yoilsho	6744	28	less	less	RBR
cord-006229-7yoilsho	6744	29	frequent	frequent	JJ
cord-006229-7yoilsho	6744	30	metastatic	metastatic	JJ
cord-006229-7yoilsho	6744	31	sites	site	NNS
cord-006229-7yoilsho	6744	32	such	such	JJ
cord-006229-7yoilsho	6744	33	as	as	IN
cord-006229-7yoilsho	6744	34	thyroid	thyroid	NN
cord-006229-7yoilsho	6744	35	gland	gland	NN
cord-006229-7yoilsho	6744	36	or	or	CC
cord-006229-7yoilsho	6744	37	spleen	spleen	NN
cord-006229-7yoilsho	6744	38	.	.	.
cord-006229-7yoilsho	6745	1	Accordingly	accordingly	RB
cord-006229-7yoilsho	6745	2	,	,	,
cord-006229-7yoilsho	6745	3	DNA	dna	NN
cord-006229-7yoilsho	6745	4	methylation	methylation	NN
cord-006229-7yoilsho	6745	5	at	at	IN
cord-006229-7yoilsho	6745	6	the	the	DT
cord-006229-7yoilsho	6745	7	identified	identify	VBN
cord-006229-7yoilsho	6745	8	CpG	CpG	NNP
cord-006229-7yoilsho	6745	9	site	site	NN
cord-006229-7yoilsho	6745	10	in	in	IN
cord-006229-7yoilsho	6745	11	the	the	DT
cord-006229-7yoilsho	6745	12	SLC16A3	slc16a3	NN
cord-006229-7yoilsho	6745	13	promoter	promoter	NN
cord-006229-7yoilsho	6745	14	was	be	VBD
cord-006229-7yoilsho	6745	15	low	low	JJ
cord-006229-7yoilsho	6745	16	in	in	IN
cord-006229-7yoilsho	6745	17	metastatic	metastatic	JJ
cord-006229-7yoilsho	6745	18	tissue	tissue	NN
cord-006229-7yoilsho	6745	19	in	in	IN
cord-006229-7yoilsho	6745	20	all	all	DT
cord-006229-7yoilsho	6745	21	investigated	investigate	VBN
cord-006229-7yoilsho	6745	22	organ	organ	NN
cord-006229-7yoilsho	6745	23	sites	site	NNS
cord-006229-7yoilsho	6745	24	.	.	.
cord-006229-7yoilsho	6746	1	An	an	DT
cord-006229-7yoilsho	6746	2	association	association	NN
cord-006229-7yoilsho	6746	3	of	of	IN
cord-006229-7yoilsho	6746	4	low	low	JJ
cord-006229-7yoilsho	6746	5	promoter	promoter	NN
cord-006229-7yoilsho	6746	6	DNA	dna	NN
cord-006229-7yoilsho	6746	7	methylation	methylation	NN
cord-006229-7yoilsho	6746	8	level	level	NN
cord-006229-7yoilsho	6746	9	at	at	IN
cord-006229-7yoilsho	6746	10	the	the	DT
cord-006229-7yoilsho	6746	11	previously	previously	RB
cord-006229-7yoilsho	6746	12	identified	identify	VBN
cord-006229-7yoilsho	6746	13	prognostic	prognostic	JJ
cord-006229-7yoilsho	6746	14	CpG	cpg	NN
cord-006229-7yoilsho	6746	15	site	site	NN
cord-006229-7yoilsho	6746	16	in	in	IN
cord-006229-7yoilsho	6746	17	metastases	metastasis	NNS
cord-006229-7yoilsho	6746	18	with	with	IN
cord-006229-7yoilsho	6746	19	poor	poor	JJ
cord-006229-7yoilsho	6746	20	tumor	tumor	NN
cord-006229-7yoilsho	6746	21	-	-	HYPH
cord-006229-7yoilsho	6746	22	specific	specific	JJ
cord-006229-7yoilsho	6746	23	survival	survival	NN
cord-006229-7yoilsho	6746	24	of	of	IN
cord-006229-7yoilsho	6746	25	the	the	DT
cord-006229-7yoilsho	6746	26	patients	patient	NNS
cord-006229-7yoilsho	6746	27	was	be	VBD
cord-006229-7yoilsho	6746	28	observed	observe	VBN
cord-006229-7yoilsho	6746	29	.	.	.
cord-006229-7yoilsho	6747	1	Conclusion	conclusion	NN
cord-006229-7yoilsho	6747	2	:	:	:
cord-006229-7yoilsho	6748	1	From	from	IN
cord-006229-7yoilsho	6748	2	these	these	DT
cord-006229-7yoilsho	6748	3	results	result	NNS
cord-006229-7yoilsho	6748	4	we	-PRON-	PRP
cord-006229-7yoilsho	6748	5	hypothesize	hypothesize	VBP
cord-006229-7yoilsho	6748	6	that	that	IN
cord-006229-7yoilsho	6748	7	DNA	dna	NN
cord-006229-7yoilsho	6748	8	methylation	methylation	NN
cord-006229-7yoilsho	6748	9	at	at	IN
cord-006229-7yoilsho	6748	10	specific	specific	JJ
cord-006229-7yoilsho	6748	11	CpG	CpG	NNP
cord-006229-7yoilsho	6748	12	sites	site	NNS
cord-006229-7yoilsho	6748	13	in	in	IN
cord-006229-7yoilsho	6748	14	the	the	DT
cord-006229-7yoilsho	6748	15	5'-regulatory	5'-regulatory	CD
cord-006229-7yoilsho	6748	16	region	region	NN
cord-006229-7yoilsho	6748	17	of	of	IN
cord-006229-7yoilsho	6748	18	MCT4	MCT4	NNP
cord-006229-7yoilsho	6748	19	may	may	MD
cord-006229-7yoilsho	6748	20	not	not	RB
cord-006229-7yoilsho	6748	21	only	only	RB
cord-006229-7yoilsho	6748	22	serve	serve	VB
cord-006229-7yoilsho	6748	23	as	as	IN
cord-006229-7yoilsho	6748	24	a	a	DT
cord-006229-7yoilsho	6748	25	predictor	predictor	NN
cord-006229-7yoilsho	6748	26	for	for	IN
cord-006229-7yoilsho	6748	27	patient	patient	JJ
cord-006229-7yoilsho	6748	28	outcome	outcome	NN
cord-006229-7yoilsho	6748	29	and	and	CC
cord-006229-7yoilsho	6748	30	as	as	IN
cord-006229-7yoilsho	6748	31	potential	potential	JJ
cord-006229-7yoilsho	6748	32	novel	novel	NN
cord-006229-7yoilsho	6748	33	target	target	NN
cord-006229-7yoilsho	6748	34	for	for	IN
cord-006229-7yoilsho	6748	35	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	6748	36	intervention	intervention	NN
cord-006229-7yoilsho	6748	37	in	in	IN
cord-006229-7yoilsho	6748	38	primary	primary	NN
cord-006229-7yoilsho	6748	39	,	,	,
cord-006229-7yoilsho	6748	40	but	but	CC
cord-006229-7yoilsho	6748	41	also	also	RB
cord-006229-7yoilsho	6748	42	for	for	IN
cord-006229-7yoilsho	6748	43	metastatic	metastatic	JJ
cord-006229-7yoilsho	6748	44	disease	disease	NN
cord-006229-7yoilsho	6748	45	.	.	.
cord-006229-7yoilsho	6749	1	Tamoxifen	Tamoxifen	NNP
cord-006229-7yoilsho	6749	2	is	be	VBZ
cord-006229-7yoilsho	6749	3	used	use	VBN
cord-006229-7yoilsho	6749	4	to	to	TO
cord-006229-7yoilsho	6749	5	treat	treat	VB
cord-006229-7yoilsho	6749	6	pre	pre	JJ
cord-006229-7yoilsho	6749	7	-	-	JJ
cord-006229-7yoilsho	6749	8	and	and	CC
cord-006229-7yoilsho	6749	9	postmenopausal	postmenopausal	JJ
cord-006229-7yoilsho	6749	10	women	woman	NNS
cord-006229-7yoilsho	6749	11	with	with	IN
cord-006229-7yoilsho	6749	12	estrogen	estrogen	NN
cord-006229-7yoilsho	6749	13	-	-	HYPH
cord-006229-7yoilsho	6749	14	receptor	receptor	NN
cord-006229-7yoilsho	6749	15	(	(	-LRB-
cord-006229-7yoilsho	6749	16	ER	ER	NNP
cord-006229-7yoilsho	6749	17	)	)	-RRB-
cord-006229-7yoilsho	6749	18	positive	positive	JJ
cord-006229-7yoilsho	6749	19	breast	breast	NN
cord-006229-7yoilsho	6749	20	cancer	cancer	NN
cord-006229-7yoilsho	6749	21	.	.	.
cord-006229-7yoilsho	6750	1	As	as	IN
cord-006229-7yoilsho	6750	2	a	a	DT
cord-006229-7yoilsho	6750	3	prodrug	prodrug	NN
cord-006229-7yoilsho	6750	4	,	,	,
cord-006229-7yoilsho	6750	5	tamoxifen	tamoxifen	NN
cord-006229-7yoilsho	6750	6	undergoes	undergo	VBZ
cord-006229-7yoilsho	6750	7	extensive	extensive	JJ
cord-006229-7yoilsho	6750	8	hepatic	hepatic	JJ
cord-006229-7yoilsho	6750	9	metabolism	metabolism	NN
cord-006229-7yoilsho	6750	10	resulting	result	VBG
cord-006229-7yoilsho	6750	11	in	in	IN
cord-006229-7yoilsho	6750	12	a	a	DT
cord-006229-7yoilsho	6750	13	complex	complex	JJ
cord-006229-7yoilsho	6750	14	mixture	mixture	NN
cord-006229-7yoilsho	6750	15	of	of	IN
cord-006229-7yoilsho	6750	16	metabolites	metabolite	NNS
cord-006229-7yoilsho	6750	17	with	with	IN
cord-006229-7yoilsho	6750	18	estrogenic	estrogenic	JJ
cord-006229-7yoilsho	6750	19	and	and	CC
cord-006229-7yoilsho	6750	20	antiestrogenic	antiestrogenic	JJ
cord-006229-7yoilsho	6750	21	effects	effect	NNS
cord-006229-7yoilsho	6750	22	.	.	.
cord-006229-7yoilsho	6751	1	While	while	IN
cord-006229-7yoilsho	6751	2	endoxifen	endoxifen	NNP
cord-006229-7yoilsho	6751	3	and	and	CC
cord-006229-7yoilsho	6751	4	(	(	-LRB-
cord-006229-7yoilsho	6751	5	Z	z	NN
cord-006229-7yoilsho	6751	6	)	)	-RRB-
cord-006229-7yoilsho	6751	7	4-hydroxytamoxifen	4-hydroxytamoxifen	CD
cord-006229-7yoilsho	6751	8	are	be	VBP
cord-006229-7yoilsho	6751	9	the	the	DT
cord-006229-7yoilsho	6751	10	most	most	RBS
cord-006229-7yoilsho	6751	11	potent	potent	JJ
cord-006229-7yoilsho	6751	12	antiestrogenic	antiestrogenic	JJ
cord-006229-7yoilsho	6751	13	metabolites	metabolite	NNS
cord-006229-7yoilsho	6751	14	,	,	,
cord-006229-7yoilsho	6751	15	bisphenol	bisphenol	NN
cord-006229-7yoilsho	6751	16	and	and	CC
cord-006229-7yoilsho	6751	17	both	both	DT
cord-006229-7yoilsho	6751	18	isomers	isomer	NNS
cord-006229-7yoilsho	6751	19	(	(	-LRB-
cord-006229-7yoilsho	6751	20	E	E	NNP
cord-006229-7yoilsho	6751	21	)	)	-RRB-
cord-006229-7yoilsho	6751	22	and	and	CC
cord-006229-7yoilsho	6751	23	(	(	-LRB-
cord-006229-7yoilsho	6751	24	Z	z	NN
cord-006229-7yoilsho	6751	25	)	)	-RRB-
cord-006229-7yoilsho	6751	26	of	of	IN
cord-006229-7yoilsho	6751	27	metabolite	metabolite	NNP
cord-006229-7yoilsho	6751	28	E	E	NNS
cord-006229-7yoilsho	6751	29	are	be	VBP
cord-006229-7yoilsho	6751	30	the	the	DT
cord-006229-7yoilsho	6751	31	most	most	RBS
cord-006229-7yoilsho	6751	32	potent	potent	JJ
cord-006229-7yoilsho	6751	33	compounds	compound	NNS
cord-006229-7yoilsho	6751	34	with	with	IN
cord-006229-7yoilsho	6751	35	estrogenic	estrogenic	JJ
cord-006229-7yoilsho	6751	36	properties	property	NNS
cord-006229-7yoilsho	6751	37	at	at	IN
cord-006229-7yoilsho	6751	38	the	the	DT
cord-006229-7yoilsho	6751	39	ER	ER	NNP
cord-006229-7yoilsho	6751	40	.	.	.
cord-006229-7yoilsho	6752	1	The	the	DT
cord-006229-7yoilsho	6752	2	mixed	mixed	JJ
cord-006229-7yoilsho	6752	3	antagonist	antagonist	NN
cord-006229-7yoilsho	6752	4	/	/	SYM
cord-006229-7yoilsho	6752	5	agonist	agonist	NN
cord-006229-7yoilsho	6752	6	pharmacodynamic	pharmacodynamic	JJ
cord-006229-7yoilsho	6752	7	effects	effect	NNS
cord-006229-7yoilsho	6752	8	of	of	IN
cord-006229-7yoilsho	6752	9	the	the	DT
cord-006229-7yoilsho	6752	10	selective	selective	JJ
cord-006229-7yoilsho	6752	11	estrogen	estrogen	NN
cord-006229-7yoilsho	6752	12	receptor	receptor	NN
cord-006229-7yoilsho	6752	13	modulator	modulator	NN
cord-006229-7yoilsho	6752	14	tamoxifen	tamoxifen	NN
cord-006229-7yoilsho	6752	15	at	at	IN
cord-006229-7yoilsho	6752	16	the	the	DT
cord-006229-7yoilsho	6752	17	ER	ER	NNP
cord-006229-7yoilsho	6752	18	have	have	VBP
cord-006229-7yoilsho	6752	19	been	be	VBN
cord-006229-7yoilsho	6752	20	mainly	mainly	RB
cord-006229-7yoilsho	6752	21	attributed	attribute	VBN
cord-006229-7yoilsho	6752	22	to	to	IN
cord-006229-7yoilsho	6752	23	tissue	tissue	VB
cord-006229-7yoilsho	6752	24	specific	specific	JJ
cord-006229-7yoilsho	6752	25	action	action	NN
cord-006229-7yoilsho	6752	26	of	of	IN
cord-006229-7yoilsho	6752	27	ER	ER	NNP
cord-006229-7yoilsho	6752	28	coregulators	coregulator	NNS
cord-006229-7yoilsho	6752	29	,	,	,
cord-006229-7yoilsho	6752	30	yet	yet	CC
cord-006229-7yoilsho	6752	31	little	little	JJ
cord-006229-7yoilsho	6752	32	is	be	VBZ
cord-006229-7yoilsho	6752	33	known	know	VBN
cord-006229-7yoilsho	6752	34	about	about	IN
cord-006229-7yoilsho	6752	35	agonistic	agonistic	JJ
cord-006229-7yoilsho	6752	36	metabolites	metabolite	NNS
cord-006229-7yoilsho	6752	37	contributing	contribute	VBG
cord-006229-7yoilsho	6752	38	to	to	IN
cord-006229-7yoilsho	6752	39	its	-PRON-	PRP$
cord-006229-7yoilsho	6752	40	estrogenic	estrogenic	JJ
cord-006229-7yoilsho	6752	41	actions	action	NNS
cord-006229-7yoilsho	6752	42	.	.	.
cord-006229-7yoilsho	6753	1	The	the	DT
cord-006229-7yoilsho	6753	2	aim	aim	NN
cord-006229-7yoilsho	6753	3	of	of	IN
cord-006229-7yoilsho	6753	4	the	the	DT
cord-006229-7yoilsho	6753	5	present	present	JJ
cord-006229-7yoilsho	6753	6	study	study	NN
cord-006229-7yoilsho	6753	7	was	be	VBD
cord-006229-7yoilsho	6753	8	to	to	TO
cord-006229-7yoilsho	6753	9	clarify	clarify	VB
cord-006229-7yoilsho	6753	10	whether	whether	IN
cord-006229-7yoilsho	6753	11	there	there	EX
cord-006229-7yoilsho	6753	12	is	be	VBZ
cord-006229-7yoilsho	6753	13	a	a	DT
cord-006229-7yoilsho	6753	14	genetic	genetic	JJ
cord-006229-7yoilsho	6753	15	component	component	NN
cord-006229-7yoilsho	6753	16	for	for	IN
cord-006229-7yoilsho	6753	17	interindividual	interindividual	JJ
cord-006229-7yoilsho	6753	18	differences	difference	NNS
cord-006229-7yoilsho	6753	19	in	in	IN
cord-006229-7yoilsho	6753	20	the	the	DT
cord-006229-7yoilsho	6753	21	formation	formation	NN
cord-006229-7yoilsho	6753	22	and	and	CC
cord-006229-7yoilsho	6753	23	clinical	clinical	JJ
cord-006229-7yoilsho	6753	24	effect	effect	NN
cord-006229-7yoilsho	6753	25	of	of	IN
cord-006229-7yoilsho	6753	26	agonistic	agonistic	JJ
cord-006229-7yoilsho	6753	27	tamoxifen	tamoxifen	NN
cord-006229-7yoilsho	6753	28	metabolites	metabolite	NNS
cord-006229-7yoilsho	6753	29	.	.	.
cord-006229-7yoilsho	6754	1	A	a	DT
cord-006229-7yoilsho	6754	2	genome	genome	NN
cord-006229-7yoilsho	6754	3	-	-	HYPH
cord-006229-7yoilsho	6754	4	wide	wide	JJ
cord-006229-7yoilsho	6754	5	association	association	NN
cord-006229-7yoilsho	6754	6	study	study	NN
cord-006229-7yoilsho	6754	7	(	(	-LRB-
cord-006229-7yoilsho	6754	8	GWAS	GWAS	NNP
cord-006229-7yoilsho	6754	9	)	)	-RRB-
cord-006229-7yoilsho	6754	10	was	be	VBD
cord-006229-7yoilsho	6754	11	conducted	conduct	VBN
cord-006229-7yoilsho	6754	12	on	on	IN
cord-006229-7yoilsho	6754	13	steady	steady	JJ
cord-006229-7yoilsho	6754	14	-	-	HYPH
cord-006229-7yoilsho	6754	15	state	state	NN
cord-006229-7yoilsho	6754	16	agonist	agonist	NN
cord-006229-7yoilsho	6754	17	plasma	plasma	NN
cord-006229-7yoilsho	6754	18	levels	level	NNS
cord-006229-7yoilsho	6754	19	in	in	IN
cord-006229-7yoilsho	6754	20	390	390	CD
cord-006229-7yoilsho	6754	21	postmenopausal	postmenopausal	JJ
cord-006229-7yoilsho	6754	22	breast	breast	NN
cord-006229-7yoilsho	6754	23	cancer	cancer	NN
cord-006229-7yoilsho	6754	24	patients	patient	NNS
cord-006229-7yoilsho	6754	25	of	of	IN
cord-006229-7yoilsho	6754	26	European	european	JJ
cord-006229-7yoilsho	6754	27	origin	origin	NN
cord-006229-7yoilsho	6754	28	who	who	WP
cord-006229-7yoilsho	6754	29	were	be	VBD
cord-006229-7yoilsho	6754	30	treated	treat	VBN
cord-006229-7yoilsho	6754	31	with	with	IN
cord-006229-7yoilsho	6754	32	20	20	CD
cord-006229-7yoilsho	6754	33	mg	mg	NNP
cord-006229-7yoilsho	6754	34	/	/	SYM
cord-006229-7yoilsho	6754	35	day	day	NN
cord-006229-7yoilsho	6754	36	of	of	IN
cord-006229-7yoilsho	6754	37	tamoxifen	tamoxifen	NN
cord-006229-7yoilsho	6754	38	for	for	IN
cord-006229-7yoilsho	6754	39	at	at	RB
cord-006229-7yoilsho	6754	40	least	least	RBS
cord-006229-7yoilsho	6754	41	6	6	CD
cord-006229-7yoilsho	6754	42	months	month	NNS
cord-006229-7yoilsho	6754	43	.	.	.
cord-006229-7yoilsho	6755	1	Plasma	plasma	NN
cord-006229-7yoilsho	6755	2	concentrations	concentration	NNS
cord-006229-7yoilsho	6755	3	of	of	IN
cord-006229-7yoilsho	6755	4	estrogenic	estrogenic	JJ
cord-006229-7yoilsho	6755	5	metabolites	metabolite	NNS
cord-006229-7yoilsho	6755	6	bisphenol	bisphenol	NN
cord-006229-7yoilsho	6755	7	,	,	,
cord-006229-7yoilsho	6755	8	(	(	-LRB-
cord-006229-7yoilsho	6755	9	E	E	NNP
cord-006229-7yoilsho	6755	10	)	)	-RRB-
cord-006229-7yoilsho	6755	11	,	,	,
cord-006229-7yoilsho	6755	12	and	and	CC
cord-006229-7yoilsho	6755	13	(	(	-LRB-
cord-006229-7yoilsho	6755	14	Z	z	NN
cord-006229-7yoilsho	6755	15	)	)	-RRB-
cord-006229-7yoilsho	6755	16	metabolite	metabolite	NN
cord-006229-7yoilsho	6755	17	E	E	NNS
cord-006229-7yoilsho	6755	18	were	be	VBD
cord-006229-7yoilsho	6755	19	quantified	quantify	VBN
cord-006229-7yoilsho	6755	20	using	use	VBG
cord-006229-7yoilsho	6755	21	a	a	DT
cord-006229-7yoilsho	6755	22	recently	recently	RB
cord-006229-7yoilsho	6755	23	established	establish	VBN
cord-006229-7yoilsho	6755	24	LC	LC	NNP
cord-006229-7yoilsho	6755	25	-	-	HYPH
cord-006229-7yoilsho	6755	26	MS	MS	NNP
cord-006229-7yoilsho	6755	27	/	/	SYM
cord-006229-7yoilsho	6755	28	MS	MS	NNP
cord-006229-7yoilsho	6755	29	method	method	NN
cord-006229-7yoilsho	6755	30	1	1	CD
cord-006229-7yoilsho	6755	31	.	.	.
cord-006229-7yoilsho	6756	1	Promising	promise	VBG
cord-006229-7yoilsho	6756	2	SNPs	snp	NNS
cord-006229-7yoilsho	6756	3	for	for	IN
cord-006229-7yoilsho	6756	4	an	an	DT
cord-006229-7yoilsho	6756	5	association	association	NN
cord-006229-7yoilsho	6756	6	between	between	IN
cord-006229-7yoilsho	6756	7	genotype	genotype	NN
cord-006229-7yoilsho	6756	8	and	and	CC
cord-006229-7yoilsho	6756	9	either	either	CC
cord-006229-7yoilsho	6756	10	plasma	plasma	NN
cord-006229-7yoilsho	6756	11	metabolite	metabolite	NN
cord-006229-7yoilsho	6756	12	concentration	concentration	NN
cord-006229-7yoilsho	6756	13	or	or	CC
cord-006229-7yoilsho	6756	14	clinical	clinical	JJ
cord-006229-7yoilsho	6756	15	outcome	outcome	NN
cord-006229-7yoilsho	6756	16	were	be	VBD
cord-006229-7yoilsho	6756	17	confirmed	confirm	VBN
cord-006229-7yoilsho	6756	18	for	for	IN
cord-006229-7yoilsho	6756	19	their	-PRON-	PRP$
cord-006229-7yoilsho	6756	20	relevance	relevance	NN
cord-006229-7yoilsho	6756	21	in	in	IN
cord-006229-7yoilsho	6756	22	an	an	DT
cord-006229-7yoilsho	6756	23	independent	independent	JJ
cord-006229-7yoilsho	6756	24	patient	patient	JJ
cord-006229-7yoilsho	6756	25	cohort	cohort	NN
cord-006229-7yoilsho	6756	26	of	of	IN
cord-006229-7yoilsho	6756	27	313	313	CD
cord-006229-7yoilsho	6756	28	premenopausal	premenopausal	JJ
cord-006229-7yoilsho	6756	29	breast	breast	NN
cord-006229-7yoilsho	6756	30	cancer	cancer	NN
cord-006229-7yoilsho	6756	31	patients	patient	NNS
cord-006229-7yoilsho	6756	32	mainly	mainly	RB
cord-006229-7yoilsho	6756	33	of	of	IN
cord-006229-7yoilsho	6756	34	European	european	JJ
cord-006229-7yoilsho	6756	35	descent	descent	NN
cord-006229-7yoilsho	6756	36	2	2	CD
cord-006229-7yoilsho	6756	37	,	,	,
cord-006229-7yoilsho	6756	38	3	3	CD
cord-006229-7yoilsho	6756	39	.	.	.
cord-006229-7yoilsho	6757	1	Twelve	twelve	CD
cord-006229-7yoilsho	6757	2	SNPs	snp	NNS
cord-006229-7yoilsho	6757	3	close	close	JJ
cord-006229-7yoilsho	6757	4	to	to	IN
cord-006229-7yoilsho	6757	5	or	or	CC
cord-006229-7yoilsho	6757	6	above	above	IN
cord-006229-7yoilsho	6757	7	genome	genome	NN
cord-006229-7yoilsho	6757	8	-	-	HYPH
cord-006229-7yoilsho	6757	9	wide	wide	JJ
cord-006229-7yoilsho	6757	10	significance	significance	NN
cord-006229-7yoilsho	6758	1	(	(	-LRB-
cord-006229-7yoilsho	6758	2	P	p	NN
cord-006229-7yoilsho	6758	3	<	<	XX
cord-006229-7yoilsho	6758	4	5E-08	5e-08	CD
cord-006229-7yoilsho	6758	5	)	)	-RRB-
cord-006229-7yoilsho	6758	6	were	be	VBD
cord-006229-7yoilsho	6758	7	found	find	VBN
cord-006229-7yoilsho	6758	8	to	to	TO
cord-006229-7yoilsho	6758	9	be	be	VB
cord-006229-7yoilsho	6758	10	associated	associate	VBN
cord-006229-7yoilsho	6758	11	with	with	IN
cord-006229-7yoilsho	6758	12	allele	allele	NN
cord-006229-7yoilsho	6758	13	-	-	HYPH
cord-006229-7yoilsho	6758	14	dependent	dependent	JJ
cord-006229-7yoilsho	6758	15	variable	variable	NN
cord-006229-7yoilsho	6758	16	(	(	-LRB-
cord-006229-7yoilsho	6758	17	E	e	NN
cord-006229-7yoilsho	6758	18	)	)	-RRB-
cord-006229-7yoilsho	6758	19	or	or	CC
cord-006229-7yoilsho	6758	20	(	(	-LRB-
cord-006229-7yoilsho	6758	21	Z	z	NN
cord-006229-7yoilsho	6758	22	)	)	-RRB-
cord-006229-7yoilsho	6758	23	metabolite	metabolite	NN
cord-006229-7yoilsho	6758	24	E	e	NN
cord-006229-7yoilsho	6758	25	plasma	plasma	NN
cord-006229-7yoilsho	6758	26	levels	level	NNS
cord-006229-7yoilsho	6758	27	,	,	,
cord-006229-7yoilsho	6758	28	while	while	IN
cord-006229-7yoilsho	6758	29	no	no	DT
cord-006229-7yoilsho	6758	30	genomic	genomic	JJ
cord-006229-7yoilsho	6758	31	hit	hit	NN
cord-006229-7yoilsho	6758	32	was	be	VBD
cord-006229-7yoilsho	6758	33	found	find	VBN
cord-006229-7yoilsho	6758	34	for	for	IN
cord-006229-7yoilsho	6758	35	the	the	DT
cord-006229-7yoilsho	6758	36	tamoxifen	tamoxifen	NNP
cord-006229-7yoilsho	6758	37	metabolite	metabolite	NNP
cord-006229-7yoilsho	6758	38	bisphenol	bisphenol	NNP
cord-006229-7yoilsho	6758	39	.	.	.
cord-006229-7yoilsho	6759	1	Here	here	RB
cord-006229-7yoilsho	6759	2	,	,	,
cord-006229-7yoilsho	6759	3	positive	positive	JJ
cord-006229-7yoilsho	6759	4	intergenic	intergenic	JJ
cord-006229-7yoilsho	6759	5	or	or	CC
cord-006229-7yoilsho	6759	6	genic	genic	JJ
cord-006229-7yoilsho	6759	7	regions	region	NNS
cord-006229-7yoilsho	6759	8	mapped	map	VBN
cord-006229-7yoilsho	6759	9	to	to	IN
cord-006229-7yoilsho	6759	10	chromosomes	chromosome	NNS
cord-006229-7yoilsho	6759	11	1	1	CD
cord-006229-7yoilsho	6759	12	,	,	,
cord-006229-7yoilsho	6759	13	2	2	CD
cord-006229-7yoilsho	6759	14	and	and	CC
cord-006229-7yoilsho	6759	15	16	16	CD
cord-006229-7yoilsho	6759	16	for	for	IN
cord-006229-7yoilsho	6759	17	(	(	-LRB-
cord-006229-7yoilsho	6759	18	E	e	NN
cord-006229-7yoilsho	6759	19	)	)	-RRB-
cord-006229-7yoilsho	6759	20	metabolite	metabolite	NN
cord-006229-7yoilsho	6759	21	E	e	NN
cord-006229-7yoilsho	6759	22	and	and	CC
cord-006229-7yoilsho	6759	23	to	to	IN
cord-006229-7yoilsho	6759	24	chromosomes	chromosome	NNS
cord-006229-7yoilsho	6759	25	15	15	CD
cord-006229-7yoilsho	6759	26	and	and	CC
cord-006229-7yoilsho	6759	27	18	18	CD
cord-006229-7yoilsho	6759	28	for	for	IN
cord-006229-7yoilsho	6759	29	(	(	-LRB-
cord-006229-7yoilsho	6759	30	Z	z	NN
cord-006229-7yoilsho	6759	31	)	)	-RRB-
cord-006229-7yoilsho	6759	32	metabolite	metabolite	NN
cord-006229-7yoilsho	6759	33	E.	E.	NNP
cord-006229-7yoilsho	6760	1	Upon	upon	IN
cord-006229-7yoilsho	6760	2	genotyping	genotyping	NN
cord-006229-7yoilsho	6760	3	of	of	IN
cord-006229-7yoilsho	6760	4	the	the	DT
cord-006229-7yoilsho	6760	5	validation	validation	NN
cord-006229-7yoilsho	6760	6	cohort	cohort	NN
cord-006229-7yoilsho	6760	7	,	,	,
cord-006229-7yoilsho	6760	8	two	two	CD
cord-006229-7yoilsho	6760	9	genetic	genetic	JJ
cord-006229-7yoilsho	6760	10	loci	locus	NNS
cord-006229-7yoilsho	6760	11	with	with	IN
cord-006229-7yoilsho	6760	12	minor	minor	JJ
cord-006229-7yoilsho	6760	13	allele	allele	NN
cord-006229-7yoilsho	6760	14	frequencies	frequency	NNS
cord-006229-7yoilsho	6760	15	<	<	XX
cord-006229-7yoilsho	6760	16	5	5	CD
cord-006229-7yoilsho	6760	17	%	%	NN
cord-006229-7yoilsho	6760	18	were	be	VBD
cord-006229-7yoilsho	6760	19	confirmed	confirm	VBN
cord-006229-7yoilsho	6760	20	as	as	IN
cord-006229-7yoilsho	6760	21	putative	putative	JJ
cord-006229-7yoilsho	6760	22	candidates	candidate	NNS
cord-006229-7yoilsho	6760	23	:	:	:
cord-006229-7yoilsho	6761	1	rs662106	rs662106	NNP
cord-006229-7yoilsho	6761	2	was	be	VBD
cord-006229-7yoilsho	6761	3	associated	associate	VBN
cord-006229-7yoilsho	6761	4	with	with	IN
cord-006229-7yoilsho	6761	5	a	a	DT
cord-006229-7yoilsho	6761	6	21	21	CD
cord-006229-7yoilsho	6761	7	-	-	SYM
cord-006229-7yoilsho	6761	8	39	39	CD
cord-006229-7yoilsho	6761	9	%	%	NN
cord-006229-7yoilsho	6761	10	variant	variant	JJ
cord-006229-7yoilsho	6761	11	allele	allele	NN
cord-006229-7yoilsho	6761	12	-	-	HYPH
cord-006229-7yoilsho	6761	13	dependent	dependent	JJ
cord-006229-7yoilsho	6761	14	increase	increase	NN
cord-006229-7yoilsho	6761	15	of	of	IN
cord-006229-7yoilsho	6761	16	(	(	-LRB-
cord-006229-7yoilsho	6761	17	E	e	NN
cord-006229-7yoilsho	6761	18	)	)	-RRB-
cord-006229-7yoilsho	6761	19	and	and	CC
cord-006229-7yoilsho	6761	20	(	(	-LRB-
cord-006229-7yoilsho	6761	21	Z	z	NN
cord-006229-7yoilsho	6761	22	)	)	-RRB-
cord-006229-7yoilsho	6761	23	metabolite	metabolite	NN
cord-006229-7yoilsho	6761	24	E	e	NN
cord-006229-7yoilsho	6761	25	isomers	isomer	NNS
cord-006229-7yoilsho	6761	26	(	(	-LRB-
cord-006229-7yoilsho	6761	27	p	p	NN
cord-006229-7yoilsho	6761	28	<	<	XX
cord-006229-7yoilsho	6761	29	0.05	0.05	CD
cord-006229-7yoilsho	6761	30	)	)	-RRB-
cord-006229-7yoilsho	6761	31	,	,	,
cord-006229-7yoilsho	6761	32	and	and	CC
cord-006229-7yoilsho	6761	33	rs3731872	rs3731872	NNP
cord-006229-7yoilsho	6761	34	,	,	,
cord-006229-7yoilsho	6761	35	mapping	map	VBG
cord-006229-7yoilsho	6761	36	to	to	IN
cord-006229-7yoilsho	6761	37	a	a	DT
cord-006229-7yoilsho	6761	38	gene	gene	NN
cord-006229-7yoilsho	6761	39	encoding	encoding	NN
cord-006229-7yoilsho	6761	40	zinc	zinc	NN
cord-006229-7yoilsho	6761	41	finger	finger	NN
cord-006229-7yoilsho	6761	42	protein	protein	NN
cord-006229-7yoilsho	6761	43	ZNF124	ZNF124	NNP
cord-006229-7yoilsho	6761	44	,	,	,
cord-006229-7yoilsho	6761	45	was	be	VBD
cord-006229-7yoilsho	6761	46	associated	associate	VBN
cord-006229-7yoilsho	6761	47	with	with	IN
cord-006229-7yoilsho	6761	48	increased	increase	VBN
cord-006229-7yoilsho	6761	49	risk	risk	NN
cord-006229-7yoilsho	6761	50	of	of	IN
cord-006229-7yoilsho	6761	51	reccurrence	reccurrence	NN
cord-006229-7yoilsho	6761	52	or	or	CC
cord-006229-7yoilsho	6761	53	death	death	NN
cord-006229-7yoilsho	6761	54	(	(	-LRB-
cord-006229-7yoilsho	6761	55	HR	hr	NN
cord-006229-7yoilsho	6761	56	carriers	carrier	NNS
cord-006229-7yoilsho	6761	57	2.6	2.6	CD
cord-006229-7yoilsho	6762	1	,	,	,
cord-006229-7yoilsho	6762	2	95	95	CD
cord-006229-7yoilsho	6762	3	%	%	NN
cord-006229-7yoilsho	6762	4	CI	ci	NN
cord-006229-7yoilsho	6762	5	:	:	:
cord-006229-7yoilsho	6762	6	1.3	1.3	CD
cord-006229-7yoilsho	6762	7	-3.4	-3.4	NNS
cord-006229-7yoilsho	6762	8	;	;	:
cord-006229-7yoilsho	6762	9	P	p	NN
cord-006229-7yoilsho	6762	10	<	<	XX
cord-006229-7yoilsho	6762	11	0.005	0.005	CD
cord-006229-7yoilsho	6762	12	)	)	-RRB-
cord-006229-7yoilsho	6762	13	.	.	.
cord-006229-7yoilsho	6763	1	These	these	DT
cord-006229-7yoilsho	6763	2	findings	finding	NNS
cord-006229-7yoilsho	6763	3	suggest	suggest	VBP
cord-006229-7yoilsho	6763	4	the	the	DT
cord-006229-7yoilsho	6763	5	existence	existence	NN
cord-006229-7yoilsho	6763	6	of	of	IN
cord-006229-7yoilsho	6763	7	genetic	genetic	JJ
cord-006229-7yoilsho	6763	8	loci	locus	NNS
cord-006229-7yoilsho	6763	9	that	that	WDT
cord-006229-7yoilsho	6763	10	may	may	MD
cord-006229-7yoilsho	6763	11	contribute	contribute	VB
cord-006229-7yoilsho	6763	12	to	to	IN
cord-006229-7yoilsho	6763	13	the	the	DT
cord-006229-7yoilsho	6763	14	formation	formation	NN
cord-006229-7yoilsho	6763	15	and	and	CC
cord-006229-7yoilsho	6763	16	clinical	clinical	JJ
cord-006229-7yoilsho	6763	17	effect	effect	NN
cord-006229-7yoilsho	6763	18	of	of	IN
cord-006229-7yoilsho	6763	19	estrogenic	estrogenic	JJ
cord-006229-7yoilsho	6763	20	tamoxifen	tamoxifen	NN
cord-006229-7yoilsho	6763	21	metabolites	metabolite	NNS
cord-006229-7yoilsho	6763	22	and	and	CC
cord-006229-7yoilsho	6763	23	therefore	therefore	RB
cord-006229-7yoilsho	6763	24	could	could	MD
cord-006229-7yoilsho	6763	25	explain	explain	VB
cord-006229-7yoilsho	6763	26	therapeutic	therapeutic	JJ
cord-006229-7yoilsho	6763	27	failure	failure	NN
cord-006229-7yoilsho	6763	28	of	of	IN
cord-006229-7yoilsho	6763	29	tamoxifen	tamoxifen	NN
cord-006229-7yoilsho	6763	30	and/or	and/or	CC
cord-006229-7yoilsho	6763	31	the	the	DT
cord-006229-7yoilsho	6763	32	occurrence	occurrence	NN
cord-006229-7yoilsho	6763	33	of	of	IN
cord-006229-7yoilsho	6763	34	adverse	adverse	JJ
cord-006229-7yoilsho	6763	35	events	event	NNS
cord-006229-7yoilsho	6763	36	during	during	IN
cord-006229-7yoilsho	6763	37	treatment	treatment	NN
cord-006229-7yoilsho	6763	38	.	.	.
cord-006229-7yoilsho	6764	1	Introduction	introduction	NN
cord-006229-7yoilsho	6764	2	:	:	:
cord-006229-7yoilsho	6765	1	Metabolomic	Metabolomic	NNP
cord-006229-7yoilsho	6765	2	monitoring	monitoring	NN
cord-006229-7yoilsho	6765	3	of	of	IN
cord-006229-7yoilsho	6765	4	endogenous	endogenous	JJ
cord-006229-7yoilsho	6765	5	biomarkers	biomarker	NNS
cord-006229-7yoilsho	6765	6	is	be	VBZ
cord-006229-7yoilsho	6765	7	of	of	IN
cord-006229-7yoilsho	6765	8	increasing	increase	VBG
cord-006229-7yoilsho	6765	9	importance	importance	NN
cord-006229-7yoilsho	6765	10	for	for	IN
cord-006229-7yoilsho	6765	11	the	the	DT
cord-006229-7yoilsho	6765	12	assessment	assessment	NN
cord-006229-7yoilsho	6765	13	of	of	IN
cord-006229-7yoilsho	6765	14	drug	drug	NN
cord-006229-7yoilsho	6765	15	safety	safety	NN
cord-006229-7yoilsho	6765	16	and	and	CC
cord-006229-7yoilsho	6765	17	efficacy	efficacy	NN
cord-006229-7yoilsho	6765	18	during	during	IN
cord-006229-7yoilsho	6765	19	clinical	clinical	JJ
cord-006229-7yoilsho	6765	20	drug	drug	NN
cord-006229-7yoilsho	6765	21	development	development	NN
cord-006229-7yoilsho	6765	22	.	.	.
cord-006229-7yoilsho	6766	1	Myrcludex	Myrcludex	NNP
cord-006229-7yoilsho	6766	2	B	B	NNP
cord-006229-7yoilsho	6766	3	,	,	,
cord-006229-7yoilsho	6766	4	a	a	DT
cord-006229-7yoilsho	6766	5	novel	novel	JJ
cord-006229-7yoilsho	6766	6	lipopetide	lipopetide	NN
cord-006229-7yoilsho	6766	7	-	-	HYPH
cord-006229-7yoilsho	6766	8	based	base	VBN
cord-006229-7yoilsho	6766	9	entry	entry	NN
cord-006229-7yoilsho	6766	10	inhibitor	inhibitor	NN
cord-006229-7yoilsho	6766	11	for	for	IN
cord-006229-7yoilsho	6766	12	the	the	DT
cord-006229-7yoilsho	6766	13	therapy	therapy	NN
cord-006229-7yoilsho	6766	14	of	of	IN
cord-006229-7yoilsho	6766	15	hepatitis	hepatitis	NNP
cord-006229-7yoilsho	6766	16	B	B	NNP
cord-006229-7yoilsho	6766	17	and	and	CC
cord-006229-7yoilsho	6766	18	D	D	NNP
cord-006229-7yoilsho	6766	19	,	,	,
cord-006229-7yoilsho	6766	20	exerts	exert	VBZ
cord-006229-7yoilsho	6766	21	its	-PRON-	PRP$
cord-006229-7yoilsho	6766	22	function	function	NN
cord-006229-7yoilsho	6766	23	through	through	IN
cord-006229-7yoilsho	6766	24	inhibition	inhibition	NN
cord-006229-7yoilsho	6766	25	of	of	IN
cord-006229-7yoilsho	6766	26	the	the	DT
cord-006229-7yoilsho	6766	27	hepatic	hepatic	JJ
cord-006229-7yoilsho	6766	28	bile	bile	NN
cord-006229-7yoilsho	6766	29	acid	acid	NN
cord-006229-7yoilsho	6766	30	transporter	transporter	NN
cord-006229-7yoilsho	6766	31	Na	Na	NNP
cord-006229-7yoilsho	6767	1	+	+	CC
cord-006229-7yoilsho	6768	1	-taurocholate	-taurocholate	:
cord-006229-7yoilsho	6768	2	cotransporting	cotransporte	VBG
cord-006229-7yoilsho	6768	3	polypeptide	polypeptide	NN
cord-006229-7yoilsho	6768	4	(	(	-LRB-
cord-006229-7yoilsho	6768	5	NTCP	NTCP	NNP
cord-006229-7yoilsho	6768	6	)	)	-RRB-
cord-006229-7yoilsho	6768	7	.	.	.
cord-006229-7yoilsho	6769	1	In	in	IN
cord-006229-7yoilsho	6769	2	order	order	NN
cord-006229-7yoilsho	6769	3	to	to	TO
cord-006229-7yoilsho	6769	4	assess	assess	VB
cord-006229-7yoilsho	6769	5	a	a	DT
cord-006229-7yoilsho	6769	6	myrcludex	myrcludex	JJ
cord-006229-7yoilsho	6769	7	Binduced	Binduced	NNP
cord-006229-7yoilsho	6769	8	metabolomic	metabolomic	JJ
cord-006229-7yoilsho	6769	9	response	response	NN
cord-006229-7yoilsho	6769	10	in	in	IN
cord-006229-7yoilsho	6769	11	humans	human	NNS
cord-006229-7yoilsho	6769	12	,	,	,
cord-006229-7yoilsho	6769	13	LC	LC	NNP
cord-006229-7yoilsho	6769	14	/	/	SYM
cord-006229-7yoilsho	6769	15	MS	MS	NNP
cord-006229-7yoilsho	6769	16	-	-	HYPH
cord-006229-7yoilsho	6769	17	based	base	VBN
cord-006229-7yoilsho	6769	18	monitoring	monitoring	NN
cord-006229-7yoilsho	6769	19	of	of	IN
cord-006229-7yoilsho	6769	20	endogenous	endogenous	JJ
cord-006229-7yoilsho	6769	21	metabolites	metabolite	NNS
cord-006229-7yoilsho	6769	22	was	be	VBD
cord-006229-7yoilsho	6769	23	performed	perform	VBN
cord-006229-7yoilsho	6769	24	in	in	IN
cord-006229-7yoilsho	6769	25	blood	blood	NN
cord-006229-7yoilsho	6769	26	and	and	CC
cord-006229-7yoilsho	6769	27	urine	urine	NN
cord-006229-7yoilsho	6769	28	samples	sample	NNS
cord-006229-7yoilsho	6769	29	from	from	IN
cord-006229-7yoilsho	6769	30	healthy	healthy	JJ
cord-006229-7yoilsho	6769	31	individuals	individual	NNS
cord-006229-7yoilsho	6769	32	before	before	IN
cord-006229-7yoilsho	6769	33	and	and	CC
cord-006229-7yoilsho	6769	34	during	during	IN
cord-006229-7yoilsho	6769	35	treatment	treatment	NN
cord-006229-7yoilsho	6769	36	with	with	IN
cord-006229-7yoilsho	6769	37	myrcludex	myrcludex	NNP
cord-006229-7yoilsho	6769	38	B.	B.	NNP
cord-006229-7yoilsho	6769	39	Methods	Methods	NNP
cord-006229-7yoilsho	6769	40	:	:	:
cord-006229-7yoilsho	6769	41	Plasma	plasma	NN
cord-006229-7yoilsho	6769	42	and	and	CC
cord-006229-7yoilsho	6769	43	urine	urine	NN
cord-006229-7yoilsho	6769	44	samples	sample	NNS
cord-006229-7yoilsho	6769	45	were	be	VBD
cord-006229-7yoilsho	6769	46	collected	collect	VBN
cord-006229-7yoilsho	6769	47	from	from	IN
cord-006229-7yoilsho	6769	48	healthy	healthy	JJ
cord-006229-7yoilsho	6769	49	volunteers	volunteer	NNS
cord-006229-7yoilsho	6769	50	participating	participate	VBG
cord-006229-7yoilsho	6769	51	in	in	IN
cord-006229-7yoilsho	6769	52	clinical	clinical	JJ
cord-006229-7yoilsho	6769	53	phase	phase	NN
cord-006229-7yoilsho	6769	54	I	-PRON-	PRP
cord-006229-7yoilsho	6769	55	trials	trial	NNS
cord-006229-7yoilsho	6769	56	to	to	TO
cord-006229-7yoilsho	6769	57	evaluate	evaluate	VB
cord-006229-7yoilsho	6769	58	safety	safety	NN
cord-006229-7yoilsho	6769	59	,	,	,
cord-006229-7yoilsho	6769	60	tolerability	tolerability	NN
cord-006229-7yoilsho	6769	61	,	,	,
cord-006229-7yoilsho	6769	62	and	and	CC
cord-006229-7yoilsho	6769	63	pharmacokinetics	pharmacokinetic	NNS
cord-006229-7yoilsho	6769	64	of	of	IN
cord-006229-7yoilsho	6769	65	single	single	JJ
cord-006229-7yoilsho	6769	66	doses	dose	NNS
cord-006229-7yoilsho	6769	67	of	of	IN
cord-006229-7yoilsho	6769	68	the	the	DT
cord-006229-7yoilsho	6769	69	NTCP	NTCP	NNP
cord-006229-7yoilsho	6769	70	inhibitor	inhibitor	NN
cord-006229-7yoilsho	6770	1	myrcludex	myrcludex	NNP
cord-006229-7yoilsho	6771	1	B.	B.	NNP
cord-006229-7yoilsho	6771	2	Using	use	VBG
cord-006229-7yoilsho	6771	3	quadrupole	quadrupole	JJ
cord-006229-7yoilsho	6771	4	time	time	NN
cord-006229-7yoilsho	6771	5	-	-	HYPH
cord-006229-7yoilsho	6771	6	of	of	IN
cord-006229-7yoilsho	6771	7	-	-	HYPH
cord-006229-7yoilsho	6771	8	flight	flight	NN
cord-006229-7yoilsho	6771	9	mass	mass	NN
cord-006229-7yoilsho	6771	10	spectrometry	spectrometry	NN
cord-006229-7yoilsho	6771	11	coupled	couple	VBN
cord-006229-7yoilsho	6771	12	to	to	IN
cord-006229-7yoilsho	6771	13	reversed	reverse	VBN
cord-006229-7yoilsho	6771	14	-	-	HYPH
cord-006229-7yoilsho	6771	15	phase	phase	NN
cord-006229-7yoilsho	6771	16	chromatography	chromatography	NN
cord-006229-7yoilsho	6771	17	(	(	-LRB-
cord-006229-7yoilsho	6771	18	LC	LC	NNP
cord-006229-7yoilsho	6771	19	-	-	HYPH
cord-006229-7yoilsho	6771	20	QTOF	QTOF	NNP
cord-006229-7yoilsho	6771	21	-	-	HYPH
cord-006229-7yoilsho	6771	22	MS	MS	NNP
cord-006229-7yoilsho	6771	23	)	)	-RRB-
cord-006229-7yoilsho	6772	1	a	a	DT
cord-006229-7yoilsho	6772	2	set	set	NN
cord-006229-7yoilsho	6772	3	of	of	IN
cord-006229-7yoilsho	6772	4	15	15	CD
cord-006229-7yoilsho	6772	5	known	know	VBN
cord-006229-7yoilsho	6772	6	NTCP	ntcp	NN
cord-006229-7yoilsho	6772	7	substrates	substrate	NNS
cord-006229-7yoilsho	6772	8	(	(	-LRB-
cord-006229-7yoilsho	6772	9	bile	bile	NN
cord-006229-7yoilsho	6772	10	acids	acid	NNS
cord-006229-7yoilsho	6772	11	)	)	-RRB-
cord-006229-7yoilsho	6772	12	was	be	VBD
cord-006229-7yoilsho	6772	13	quantified	quantify	VBN
cord-006229-7yoilsho	6772	14	by	by	IN
cord-006229-7yoilsho	6772	15	targeted	target	VBN
cord-006229-7yoilsho	6772	16	metabolomics	metabolomic	NNS
cord-006229-7yoilsho	6772	17	.	.	.
cord-006229-7yoilsho	6773	1	Protein	protein	NN
cord-006229-7yoilsho	6773	2	precipitation	precipitation	NN
cord-006229-7yoilsho	6773	3	was	be	VBD
cord-006229-7yoilsho	6773	4	performed	perform	VBN
cord-006229-7yoilsho	6773	5	in	in	IN
cord-006229-7yoilsho	6773	6	the	the	DT
cord-006229-7yoilsho	6773	7	presence	presence	NN
cord-006229-7yoilsho	6773	8	of	of	IN
cord-006229-7yoilsho	6773	9	deuterium	deuterium	NN
cord-006229-7yoilsho	6773	10	-	-	HYPH
cord-006229-7yoilsho	6773	11	labeled	label	VBN
cord-006229-7yoilsho	6773	12	internal	internal	JJ
cord-006229-7yoilsho	6773	13	standards	standard	NNS
cord-006229-7yoilsho	6773	14	(	(	-LRB-
cord-006229-7yoilsho	6773	15	ISTDs	istd	NNS
cord-006229-7yoilsho	6773	16	)	)	-RRB-
cord-006229-7yoilsho	6773	17	which	which	WDT
cord-006229-7yoilsho	6773	18	allowed	allow	VBD
cord-006229-7yoilsho	6773	19	absolute	absolute	JJ
cord-006229-7yoilsho	6773	20	bile	bile	NN
cord-006229-7yoilsho	6773	21	acid	acid	NN
cord-006229-7yoilsho	6773	22	(	(	-LRB-
cord-006229-7yoilsho	6773	23	BA	ba	NN
cord-006229-7yoilsho	6773	24	)	)	-RRB-
cord-006229-7yoilsho	6773	25	quantification	quantification	NN
cord-006229-7yoilsho	6773	26	in	in	IN
cord-006229-7yoilsho	6773	27	low	low	JJ
cord-006229-7yoilsho	6773	28	amounts	amount	NNS
cord-006229-7yoilsho	6773	29	of	of	IN
cord-006229-7yoilsho	6773	30	plasma	plasma	NN
cord-006229-7yoilsho	6773	31	.	.	.
cord-006229-7yoilsho	6774	1	BA	BA	NNP
cord-006229-7yoilsho	6774	2	profiling	profile	VBG
cord-006229-7yoilsho	6774	3	in	in	IN
cord-006229-7yoilsho	6774	4	urine	urine	NN
cord-006229-7yoilsho	6774	5	was	be	VBD
cord-006229-7yoilsho	6774	6	performed	perform	VBN
cord-006229-7yoilsho	6774	7	after	after	IN
cord-006229-7yoilsho	6774	8	dilution	dilution	NN
cord-006229-7yoilsho	6774	9	with	with	IN
cord-006229-7yoilsho	6774	10	methanol	methanol	NN
cord-006229-7yoilsho	6774	11	/	/	SYM
cord-006229-7yoilsho	6774	12	water	water	NN
cord-006229-7yoilsho	6774	13	(	(	-LRB-
cord-006229-7yoilsho	6774	14	1:1	1:1	LS
cord-006229-7yoilsho	6774	15	)	)	-RRB-
cord-006229-7yoilsho	6774	16	in	in	IN
cord-006229-7yoilsho	6774	17	the	the	DT
cord-006229-7yoilsho	6774	18	presence	presence	NN
cord-006229-7yoilsho	6774	19	of	of	IN
cord-006229-7yoilsho	6774	20	ISTDs	istd	NNS
cord-006229-7yoilsho	6774	21	.	.	.
cord-006229-7yoilsho	6775	1	Both	both	DT
cord-006229-7yoilsho	6775	2	methods	method	NNS
cord-006229-7yoilsho	6775	3	were	be	VBD
cord-006229-7yoilsho	6775	4	validated	validate	VBN
cord-006229-7yoilsho	6775	5	according	accord	VBG
cord-006229-7yoilsho	6775	6	to	to	IN
cord-006229-7yoilsho	6775	7	FDA	FDA	NNP
cord-006229-7yoilsho	6775	8	guidance	guidance	NN
cord-006229-7yoilsho	6775	9	and	and	CC
cord-006229-7yoilsho	6775	10	applied	apply	VBD
cord-006229-7yoilsho	6775	11	to	to	TO
cord-006229-7yoilsho	6775	12	monitor	monitor	VB
cord-006229-7yoilsho	6775	13	the	the	DT
cord-006229-7yoilsho	6775	14	effect	effect	NN
cord-006229-7yoilsho	6775	15	of	of	IN
cord-006229-7yoilsho	6775	16	myrcludex	myrcludex	NN
cord-006229-7yoilsho	6775	17	B	B	NNP
cord-006229-7yoilsho	6775	18	treatment	treatment	NN
cord-006229-7yoilsho	6775	19	on	on	IN
cord-006229-7yoilsho	6775	20	human	human	JJ
cord-006229-7yoilsho	6775	21	bile	bile	NN
cord-006229-7yoilsho	6775	22	acid	acid	NN
cord-006229-7yoilsho	6775	23	homeostasis	homeostasis	NN
cord-006229-7yoilsho	6775	24	.	.	.
cord-006229-7yoilsho	6776	1	Results	result	NNS
cord-006229-7yoilsho	6776	2	:	:	:
cord-006229-7yoilsho	6777	1	Dynamic	dynamic	JJ
cord-006229-7yoilsho	6777	2	quantification	quantification	NN
cord-006229-7yoilsho	6777	3	in	in	IN
cord-006229-7yoilsho	6777	4	plasma	plasma	NN
cord-006229-7yoilsho	6777	5	and	and	CC
cord-006229-7yoilsho	6777	6	urine	urine	NN
cord-006229-7yoilsho	6777	7	was	be	VBD
cord-006229-7yoilsho	6777	8	achieved	achieve	VBN
cord-006229-7yoilsho	6777	9	in	in	IN
cord-006229-7yoilsho	6777	10	the	the	DT
cord-006229-7yoilsho	6777	11	range	range	NN
cord-006229-7yoilsho	6777	12	from	from	IN
cord-006229-7yoilsho	6777	13	7.8	7.8	CD
cord-006229-7yoilsho	6777	14	nM	nm	NN
cord-006229-7yoilsho	6777	15	to	to	IN
cord-006229-7yoilsho	6777	16	10000	10000	CD
cord-006229-7yoilsho	6777	17	nM	nm	NN
cord-006229-7yoilsho	6777	18	depending	depend	VBG
cord-006229-7yoilsho	6777	19	on	on	IN
cord-006229-7yoilsho	6777	20	the	the	DT
cord-006229-7yoilsho	6777	21	BA	BA	NNP
cord-006229-7yoilsho	6777	22	species	specie	NNS
cord-006229-7yoilsho	6777	23	analyzed	analyze	VBN
cord-006229-7yoilsho	6777	24	.	.	.
cord-006229-7yoilsho	6778	1	Intraday	intraday	NN
cord-006229-7yoilsho	6778	2	-	-	:
cord-006229-7yoilsho	6778	3	and	and	CC
cord-006229-7yoilsho	6778	4	interday	interday	NNP
cord-006229-7yoilsho	6778	5	accuracy	accuracy	NN
cord-006229-7yoilsho	6778	6	and	and	CC
cord-006229-7yoilsho	6778	7	precision	precision	NN
cord-006229-7yoilsho	6778	8	were	be	VBD
cord-006229-7yoilsho	6778	9	in	in	IN
cord-006229-7yoilsho	6778	10	the	the	DT
cord-006229-7yoilsho	6778	11	15	15	CD
cord-006229-7yoilsho	6778	12	%	%	NN
cord-006229-7yoilsho	6778	13	tolerance	tolerance	NN
cord-006229-7yoilsho	6778	14	range	range	NN
cord-006229-7yoilsho	6778	15	for	for	IN
cord-006229-7yoilsho	6778	16	all	all	DT
cord-006229-7yoilsho	6778	17	analytes	analyte	NNS
cord-006229-7yoilsho	6778	18	in	in	IN
cord-006229-7yoilsho	6778	19	all	all	DT
cord-006229-7yoilsho	6778	20	matrices	matrix	NNS
cord-006229-7yoilsho	6778	21	.	.	.
cord-006229-7yoilsho	6779	1	Matrix	matrix	NN
cord-006229-7yoilsho	6779	2	effects	effect	NNS
cord-006229-7yoilsho	6779	3	were	be	VBD
cord-006229-7yoilsho	6779	4	between	between	IN
cord-006229-7yoilsho	6779	5	39	39	CD
cord-006229-7yoilsho	6779	6	-	-	SYM
cord-006229-7yoilsho	6779	7	104	104	CD
cord-006229-7yoilsho	6779	8	%	%	NN
cord-006229-7yoilsho	6779	9	(	(	-LRB-
cord-006229-7yoilsho	6779	10	plasma	plasma	NN
cord-006229-7yoilsho	6779	11	)	)	-RRB-
cord-006229-7yoilsho	6779	12	and	and	CC
cord-006229-7yoilsho	6779	13	31	31	CD
cord-006229-7yoilsho	6779	14	-	-	SYM
cord-006229-7yoilsho	6779	15	95	95	CD
cord-006229-7yoilsho	6779	16	%	%	NN
cord-006229-7yoilsho	6779	17	(	(	-LRB-
cord-006229-7yoilsho	6779	18	urine	urine	NN
cord-006229-7yoilsho	6779	19	)	)	-RRB-
cord-006229-7yoilsho	6779	20	,	,	,
cord-006229-7yoilsho	6779	21	apparent	apparent	JJ
cord-006229-7yoilsho	6779	22	recoveries	recovery	NNS
cord-006229-7yoilsho	6779	23	in	in	IN
cord-006229-7yoilsho	6779	24	plasma	plasma	NN
cord-006229-7yoilsho	6779	25	were	be	VBD
cord-006229-7yoilsho	6779	26	above	above	IN
cord-006229-7yoilsho	6779	27	97	97	CD
cord-006229-7yoilsho	6779	28	%	%	NN
cord-006229-7yoilsho	6779	29	.	.	.
cord-006229-7yoilsho	6780	1	Basal	basal	NN
cord-006229-7yoilsho	6780	2	plasma	plasma	NN
cord-006229-7yoilsho	6780	3	BA	ba	NN
cord-006229-7yoilsho	6780	4	level	level	NN
cord-006229-7yoilsho	6780	5	(	(	-LRB-
cord-006229-7yoilsho	6780	6	mean	mean	VB
cord-006229-7yoilsho	6780	7	±	±	NNP
cord-006229-7yoilsho	6780	8	SD	SD	NNP
cord-006229-7yoilsho	6780	9	)	)	-RRB-
cord-006229-7yoilsho	6780	10	in	in	IN
cord-006229-7yoilsho	6780	11	fasting	fast	VBG
cord-006229-7yoilsho	6780	12	healthy	healthy	JJ
cord-006229-7yoilsho	6780	13	subjects	subject	NNS
cord-006229-7yoilsho	6780	14	were	be	VBD
cord-006229-7yoilsho	6780	15	667	667	CD
cord-006229-7yoilsho	6780	16	±	±	CD
cord-006229-7yoilsho	6780	17	574	574	CD
cord-006229-7yoilsho	6780	18	nM	nm	NN
cord-006229-7yoilsho	6780	19	(	(	-LRB-
cord-006229-7yoilsho	6780	20	unconjugated	unconjugated	NNP
cord-006229-7yoilsho	6780	21	BAs	BAs	NNP
cord-006229-7yoilsho	6780	22	)	)	-RRB-
cord-006229-7yoilsho	6780	23	,	,	,
cord-006229-7yoilsho	6780	24	935	935	CD
cord-006229-7yoilsho	6780	25	±	±	CD
cord-006229-7yoilsho	6780	26	629	629	CD
cord-006229-7yoilsho	6780	27	nM	nm	NN
cord-006229-7yoilsho	6780	28	(	(	-LRB-
cord-006229-7yoilsho	6780	29	glycine	glycine	NN
cord-006229-7yoilsho	6780	30	-	-	HYPH
cord-006229-7yoilsho	6780	31	conjugated	conjugate	VBN
cord-006229-7yoilsho	6780	32	BAs	BAs	NNP
cord-006229-7yoilsho	6780	33	)	)	-RRB-
cord-006229-7yoilsho	6780	34	and	and	CC
cord-006229-7yoilsho	6780	35	104	104	CD
cord-006229-7yoilsho	6780	36	±	±	CD
cord-006229-7yoilsho	6780	37	62	62	CD
cord-006229-7yoilsho	6780	38	nM	nm	NN
cord-006229-7yoilsho	6780	39	(	(	-LRB-
cord-006229-7yoilsho	6780	40	taurine	taurine	NN
cord-006229-7yoilsho	6780	41	-	-	HYPH
cord-006229-7yoilsho	6780	42	conjugated	conjugate	VBN
cord-006229-7yoilsho	6780	43	BAs	BAs	NNP
cord-006229-7yoilsho	6780	44	)	)	-RRB-
cord-006229-7yoilsho	6780	45	.	.	.
cord-006229-7yoilsho	6781	1	Urinary	urinary	JJ
cord-006229-7yoilsho	6781	2	BA	BA	NNP
cord-006229-7yoilsho	6781	3	level	level	NN
cord-006229-7yoilsho	6781	4	(	(	-LRB-
cord-006229-7yoilsho	6781	5	nmol	nmol	NNP
cord-006229-7yoilsho	6781	6	/	/	SYM
cord-006229-7yoilsho	6781	7	g	g	NN
cord-006229-7yoilsho	6781	8	creatinine	creatinine	NN
cord-006229-7yoilsho	6781	9	)	)	-RRB-
cord-006229-7yoilsho	6781	10	were	be	VBD
cord-006229-7yoilsho	6781	11	193	193	CD
cord-006229-7yoilsho	6781	12	±	±	CD
cord-006229-7yoilsho	6781	13	225	225	CD
cord-006229-7yoilsho	6781	14	nM	nm	NN
cord-006229-7yoilsho	6781	15	(	(	-LRB-
cord-006229-7yoilsho	6781	16	unconjugated	unconjugated	JJ
cord-006229-7yoilsho	6781	17	BAs	BAs	NNP
cord-006229-7yoilsho	6781	18	)	)	-RRB-
cord-006229-7yoilsho	6781	19	,	,	,
cord-006229-7yoilsho	6781	20	89	89	CD
cord-006229-7yoilsho	6781	21	±	±	CD
cord-006229-7yoilsho	6781	22	29	29	CD
cord-006229-7yoilsho	6781	23	nM	nm	NN
cord-006229-7yoilsho	6781	24	(	(	-LRB-
cord-006229-7yoilsho	6781	25	glycine	glycine	NN
cord-006229-7yoilsho	6781	26	-	-	HYPH
cord-006229-7yoilsho	6781	27	conjugated	conjugate	VBN
cord-006229-7yoilsho	6781	28	BAs	BAs	NNP
cord-006229-7yoilsho	6781	29	)	)	-RRB-
cord-006229-7yoilsho	6781	30	and	and	CC
cord-006229-7yoilsho	6781	31	6	6	CD
cord-006229-7yoilsho	6781	32	±	±	CD
cord-006229-7yoilsho	6781	33	2	2	CD
cord-006229-7yoilsho	6781	34	nM	nm	NN
cord-006229-7yoilsho	6781	35	(	(	-LRB-
cord-006229-7yoilsho	6781	36	taurine	taurine	NN
cord-006229-7yoilsho	6781	37	-	-	HYPH
cord-006229-7yoilsho	6781	38	conjugated	conjugate	VBN
cord-006229-7yoilsho	6781	39	BAs	BAs	NNP
cord-006229-7yoilsho	6781	40	)	)	-RRB-
cord-006229-7yoilsho	6781	41	.	.	.
cord-006229-7yoilsho	6782	1	Myrcludex	Myrcludex	NNP
cord-006229-7yoilsho	6782	2	-	-	HYPH
cord-006229-7yoilsho	6782	3	induced	induce	VBN
cord-006229-7yoilsho	6782	4	NTCP	NTCP	NNP
cord-006229-7yoilsho	6782	5	inhibition	inhibition	NN
cord-006229-7yoilsho	6782	6	resulted	result	VBD
cord-006229-7yoilsho	6782	7	in	in	IN
cord-006229-7yoilsho	6782	8	significantly	significantly	RB
cord-006229-7yoilsho	6782	9	elevated	elevate	VBN
cord-006229-7yoilsho	6782	10	amounts	amount	NNS
cord-006229-7yoilsho	6782	11	of	of	IN
cord-006229-7yoilsho	6782	12	conjugated	conjugate	VBN
cord-006229-7yoilsho	6782	13	BA	BA	NNP
cord-006229-7yoilsho	6782	14	species	specie	NNS
cord-006229-7yoilsho	6782	15	demonstrating	demonstrate	VBG
cord-006229-7yoilsho	6782	16	a	a	DT
cord-006229-7yoilsho	6782	17	spillover	spillover	NN
cord-006229-7yoilsho	6782	18	of	of	IN
cord-006229-7yoilsho	6782	19	NTCP	NTCP	NNP
cord-006229-7yoilsho	6782	20	substrates	substrate	NNS
cord-006229-7yoilsho	6782	21	into	into	IN
cord-006229-7yoilsho	6782	22	the	the	DT
cord-006229-7yoilsho	6782	23	systemic	systemic	JJ
cord-006229-7yoilsho	6782	24	circulation	circulation	NN
cord-006229-7yoilsho	6782	25	.	.	.
cord-006229-7yoilsho	6783	1	Furthermore	furthermore	RB
cord-006229-7yoilsho	6783	2	,	,	,
cord-006229-7yoilsho	6783	3	higher	high	JJR
cord-006229-7yoilsho	6783	4	urinary	urinary	JJ
cord-006229-7yoilsho	6783	5	BA	BA	NNP
cord-006229-7yoilsho	6783	6	level	level	NN
cord-006229-7yoilsho	6783	7	were	be	VBD
cord-006229-7yoilsho	6783	8	observed	observe	VBN
cord-006229-7yoilsho	6783	9	during	during	IN
cord-006229-7yoilsho	6783	10	treatment	treatment	NN
cord-006229-7yoilsho	6783	11	indicating	indicate	VBG
cord-006229-7yoilsho	6783	12	accelerated	accelerate	VBN
cord-006229-7yoilsho	6783	13	elimination	elimination	NN
cord-006229-7yoilsho	6783	14	of	of	IN
cord-006229-7yoilsho	6783	15	excessive	excessive	JJ
cord-006229-7yoilsho	6783	16	BAs	ba	NNS
cord-006229-7yoilsho	6783	17	from	from	IN
cord-006229-7yoilsho	6783	18	the	the	DT
cord-006229-7yoilsho	6783	19	body	body	NN
cord-006229-7yoilsho	6783	20	.	.	.
cord-006229-7yoilsho	6784	1	Conclusion	conclusion	NN
cord-006229-7yoilsho	6784	2	:	:	:
cord-006229-7yoilsho	6785	1	LC	LC	NNP
cord-006229-7yoilsho	6785	2	/	/	SYM
cord-006229-7yoilsho	6785	3	MS	MS	NNP
cord-006229-7yoilsho	6785	4	-	-	HYPH
cord-006229-7yoilsho	6785	5	based	base	VBN
cord-006229-7yoilsho	6785	6	monitoring	monitoring	NN
cord-006229-7yoilsho	6785	7	of	of	IN
cord-006229-7yoilsho	6785	8	endogenous	endogenous	JJ
cord-006229-7yoilsho	6785	9	biomarkers	biomarker	NNS
cord-006229-7yoilsho	6785	10	has	have	VBZ
cord-006229-7yoilsho	6785	11	been	be	VBN
cord-006229-7yoilsho	6785	12	successfully	successfully	RB
cord-006229-7yoilsho	6785	13	established	establish	VBN
cord-006229-7yoilsho	6785	14	and	and	CC
cord-006229-7yoilsho	6785	15	applied	apply	VBN
cord-006229-7yoilsho	6785	16	to	to	TO
cord-006229-7yoilsho	6785	17	study	study	VB
cord-006229-7yoilsho	6785	18	the	the	DT
cord-006229-7yoilsho	6785	19	effect	effect	NN
cord-006229-7yoilsho	6785	20	of	of	IN
cord-006229-7yoilsho	6785	21	myrcludex	myrcludex	NN
cord-006229-7yoilsho	6785	22	B	B	NNP
cord-006229-7yoilsho	6785	23	treatment	treatment	NN
cord-006229-7yoilsho	6785	24	on	on	IN
cord-006229-7yoilsho	6785	25	human	human	JJ
cord-006229-7yoilsho	6785	26	BA	BA	NNP
cord-006229-7yoilsho	6785	27	metabolism	metabolism	NN
cord-006229-7yoilsho	6785	28	.	.	.
cord-006229-7yoilsho	6786	1	The	the	DT
cord-006229-7yoilsho	6786	2	results	result	NNS
cord-006229-7yoilsho	6786	3	obtained	obtain	VBN
cord-006229-7yoilsho	6786	4	by	by	IN
cord-006229-7yoilsho	6786	5	our	-PRON-	PRP$
cord-006229-7yoilsho	6786	6	assay	assay	NN
cord-006229-7yoilsho	6786	7	demonstrate	demonstrate	VBP
cord-006229-7yoilsho	6786	8	that	that	IN
cord-006229-7yoilsho	6786	9	a	a	DT
cord-006229-7yoilsho	6786	10	myrcludex	myrcludex	NN
cord-006229-7yoilsho	6786	11	-	-	HYPH
cord-006229-7yoilsho	6786	12	induced	induce	VBN
cord-006229-7yoilsho	6786	13	NTCP	NTCP	NNP
cord-006229-7yoilsho	6786	14	inhibition	inhibition	NN
cord-006229-7yoilsho	6786	15	drastically	drastically	RB
cord-006229-7yoilsho	6786	16	affects	affect	VBZ
cord-006229-7yoilsho	6786	17	human	human	JJ
cord-006229-7yoilsho	6786	18	BA	BA	NNP
cord-006229-7yoilsho	6786	19	homeostasis	homeostasis	NN
cord-006229-7yoilsho	6786	20	.	.	.
cord-006229-7yoilsho	6787	1	This	this	DT
cord-006229-7yoilsho	6787	2	observation	observation	NN
cord-006229-7yoilsho	6787	3	provides	provide	VBZ
cord-006229-7yoilsho	6787	4	valuable	valuable	JJ
cord-006229-7yoilsho	6787	5	insights	insight	NNS
cord-006229-7yoilsho	6787	6	into	into	IN
cord-006229-7yoilsho	6787	7	the	the	DT
cord-006229-7yoilsho	6787	8	drug´s	drug´s	NNP
cord-006229-7yoilsho	6787	9	mode	mode	NN
cord-006229-7yoilsho	6787	10	of	of	IN
cord-006229-7yoilsho	6787	11	action	action	NN
cord-006229-7yoilsho	6787	12	and	and	CC
cord-006229-7yoilsho	6787	13	will	will	MD
cord-006229-7yoilsho	6787	14	be	be	VB
cord-006229-7yoilsho	6787	15	indispensable	indispensable	JJ
cord-006229-7yoilsho	6787	16	for	for	IN
cord-006229-7yoilsho	6787	17	the	the	DT
cord-006229-7yoilsho	6787	18	assessment	assessment	NN
cord-006229-7yoilsho	6787	19	of	of	IN
cord-006229-7yoilsho	6787	20	side	side	NN
cord-006229-7yoilsho	6787	21	effects	effect	NNS
cord-006229-7yoilsho	6787	22	and	and	CC
cord-006229-7yoilsho	6787	23	dose	dose	NN
cord-006229-7yoilsho	6787	24	-	-	HYPH
cord-006229-7yoilsho	6787	25	finding	find	VBG
cord-006229-7yoilsho	6787	26	processes	process	NNS
cord-006229-7yoilsho	6787	27	during	during	IN
cord-006229-7yoilsho	6787	28	future	future	JJ
cord-006229-7yoilsho	6787	29	clinical	clinical	JJ
cord-006229-7yoilsho	6787	30	trials	trial	NNS
cord-006229-7yoilsho	6787	31	.	.	.
cord-006229-7yoilsho	6788	1	Further	further	JJ
cord-006229-7yoilsho	6788	2	studies	study	NNS
cord-006229-7yoilsho	6788	3	are	be	VBP
cord-006229-7yoilsho	6788	4	required	require	VBN
cord-006229-7yoilsho	6788	5	to	to	TO
cord-006229-7yoilsho	6788	6	assess	assess	VB
cord-006229-7yoilsho	6788	7	a	a	DT
cord-006229-7yoilsho	6788	8	possible	possible	JJ
cord-006229-7yoilsho	6788	9	role	role	NN
cord-006229-7yoilsho	6788	10	of	of	IN
cord-006229-7yoilsho	6788	11	BA	BA	NNP
cord-006229-7yoilsho	6788	12	modification	modification	NN
cord-006229-7yoilsho	6788	13	(	(	-LRB-
cord-006229-7yoilsho	6788	14	e.g.	e.g.	IN
cord-006229-7yoilsho	6788	15	sulfation	sulfation	NN
cord-006229-7yoilsho	6788	16	)	)	-RRB-
cord-006229-7yoilsho	6788	17	in	in	IN
cord-006229-7yoilsho	6788	18	the	the	DT
cord-006229-7yoilsho	6788	19	process	process	NN
cord-006229-7yoilsho	6788	20	of	of	IN
cord-006229-7yoilsho	6788	21	BA	BA	NNP
cord-006229-7yoilsho	6788	22	detoxification	detoxification	NN
cord-006229-7yoilsho	6788	23	during	during	IN
cord-006229-7yoilsho	6788	24	myrcludex	myrcludex	NN
cord-006229-7yoilsho	6788	25	treatment	treatment	NN
cord-006229-7yoilsho	6788	26	.	.	.
cord-006229-7yoilsho	6788	27	 	 	_SP