id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-005633-oyhpwut7	Oppert, Michael	Plasma cortisol levels before and during "low-dose" hydrocortisone therapy and their relationship to hemodynamic improvement in patients with septic shock	2000-11-18		.txt	text/plain	3935	190	49	Objectives: To compare cortisol levels during "low-dose" hydrocortisone therapy to basal and ACTH-stimulated endogenous levels and to assess whether clinical course and the need for catecholamines depend on cortisol levels and/or pretreatment adrenocortical responsiveness. Abstract Objectives: To compare cortisol levels during ªlow-doseº hydrocortisone therapy to basal and ACTH-stimulated endogenous levels and to assess whether clinical course and the need for catecholamines depend on cortisol levels and/or pretreatment adrenocortical responsiveness. Patients with ªinadequateº steroid production could be weaned from vasopressor therapy significantly faster, although their plasma free cortisol concentrations during the hydrocortisone treatment period did not differ. In contrast, two open studies [18, 19] and two recent randomized controlled trials [20, 21] have shown ªlowdoseº steroid therapy to have beneficial effects on hemodynamics and outcome in patients with septic shock, using no more than 300 mg hydrocortisone daily administered either as bolus injections of 100 mg three times daily or as continuous infusion.	./cache/cord-005633-oyhpwut7.txt	./txt/cord-005633-oyhpwut7.txt