id sid tid token lemma pos cord-024189-t7mbsr25 1 1 key key NNP cord-024189-t7mbsr25 1 2 : : : cord-024189-t7mbsr25 1 3 cord-024189-t7mbsr25 cord-024189-t7mbsr25 ADD cord-024189-t7mbsr25 2 1 authors author NNS cord-024189-t7mbsr25 2 2 : : : cord-024189-t7mbsr25 2 3 Weyand Weyand NNP cord-024189-t7mbsr25 2 4 , , , cord-024189-t7mbsr25 2 5 Cornelia Cornelia NNP cord-024189-t7mbsr25 2 6 M. M. NNP cord-024189-t7mbsr25 2 7 ; ; : cord-024189-t7mbsr25 2 8 Goronzy Goronzy NNP cord-024189-t7mbsr25 2 9 , , , cord-024189-t7mbsr25 2 10 Jörg Jörg NNP cord-024189-t7mbsr25 2 11 J. J. NNP cord-024189-t7mbsr25 2 12 title title NN cord-024189-t7mbsr25 2 13 : : : cord-024189-t7mbsr25 2 14 Vasculitides Vasculitides NNP cord-024189-t7mbsr25 2 15 date date NN cord-024189-t7mbsr25 2 16 : : : cord-024189-t7mbsr25 3 1 2008 2008 CD cord-024189-t7mbsr25 3 2 journal journal NN cord-024189-t7mbsr25 3 3 : : : cord-024189-t7mbsr25 3 4 Primer primer NN cord-024189-t7mbsr25 3 5 on on IN cord-024189-t7mbsr25 3 6 the the DT cord-024189-t7mbsr25 3 7 Rheumatic rheumatic JJ cord-024189-t7mbsr25 3 8 Diseases disease NNS cord-024189-t7mbsr25 3 9 DOI doi NN cord-024189-t7mbsr25 3 10 : : : cord-024189-t7mbsr25 3 11 10.1007/978 10.1007/978 CD cord-024189-t7mbsr25 3 12 - - HYPH cord-024189-t7mbsr25 3 13 0 0 CD cord-024189-t7mbsr25 3 14 - - HYPH cord-024189-t7mbsr25 3 15 387 387 CD cord-024189-t7mbsr25 3 16 - - HYPH cord-024189-t7mbsr25 3 17 68566 68566 CD cord-024189-t7mbsr25 3 18 - - HYPH cord-024189-t7mbsr25 3 19 3_21 3_21 CD cord-024189-t7mbsr25 3 20 sha sha NNP cord-024189-t7mbsr25 3 21 : : : cord-024189-t7mbsr25 3 22 4b78fd71010e6e73ca2a26dd60e5e81f8b78d9a4 4b78fd71010e6e73ca2a26dd60e5e81f8b78d9a4 CD cord-024189-t7mbsr25 3 23 doc_id doc_id CD cord-024189-t7mbsr25 3 24 : : : cord-024189-t7mbsr25 4 1 24189 24189 CD cord-024189-t7mbsr25 4 2 cord_uid cord_uid NN cord-024189-t7mbsr25 4 3 : : : cord-024189-t7mbsr25 5 1 t7mbsr25 t7mbsr25 NNP cord-024189-t7mbsr25 6 1 Despite despite IN cord-024189-t7mbsr25 6 2 the the DT cord-024189-t7mbsr25 6 3 spatial spatial JJ cord-024189-t7mbsr25 6 4 closeness closeness NN cord-024189-t7mbsr25 6 5 of of IN cord-024189-t7mbsr25 6 6 blood blood NN cord-024189-t7mbsr25 6 7 vessels vessel NNS cord-024189-t7mbsr25 6 8 and and CC cord-024189-t7mbsr25 6 9 inflammatory inflammatory JJ cord-024189-t7mbsr25 6 10 cells cell NNS cord-024189-t7mbsr25 6 11 , , , cord-024189-t7mbsr25 6 12 blood blood NN cord-024189-t7mbsr25 6 13 vessel vessel NN cord-024189-t7mbsr25 6 14 walls wall NNS cord-024189-t7mbsr25 6 15 are be VBP cord-024189-t7mbsr25 6 16 infrequently infrequently RB cord-024189-t7mbsr25 6 17 targeted target VBN cord-024189-t7mbsr25 6 18 by by IN cord-024189-t7mbsr25 6 19 inflammation inflammation NN cord-024189-t7mbsr25 6 20 . . . cord-024189-t7mbsr25 7 1 Giant giant JJ cord-024189-t7mbsr25 7 2 cell cell NN cord-024189-t7mbsr25 7 3 arteritis arteritis NN cord-024189-t7mbsr25 7 4 ( ( -LRB- cord-024189-t7mbsr25 7 5 GCA GCA NNP cord-024189-t7mbsr25 7 6 ) ) -RRB- cord-024189-t7mbsr25 7 7 and and CC cord-024189-t7mbsr25 7 8 Takayasu Takayasu NNP cord-024189-t7mbsr25 7 9 ’s ’s POS cord-024189-t7mbsr25 7 10 arteritis arteritis NN cord-024189-t7mbsr25 7 11 ( ( -LRB- cord-024189-t7mbsr25 7 12 TA TA NNP cord-024189-t7mbsr25 7 13 ) ) -RRB- cord-024189-t7mbsr25 7 14 are be VBP cord-024189-t7mbsr25 7 15 characterized characterize VBN cord-024189-t7mbsr25 7 16 by by IN cord-024189-t7mbsr25 7 17 inflammation inflammation NN cord-024189-t7mbsr25 7 18 directed direct VBN cord-024189-t7mbsr25 7 19 against against IN cord-024189-t7mbsr25 7 20 the the DT cord-024189-t7mbsr25 7 21 vessel vessel NN cord-024189-t7mbsr25 7 22 wall wall NN cord-024189-t7mbsr25 7 23 . . . cord-024189-t7mbsr25 8 1 GCA GCA NNP cord-024189-t7mbsr25 8 2 and and CC cord-024189-t7mbsr25 8 3 TA TA NNP cord-024189-t7mbsr25 8 4 display display VB cord-024189-t7mbsr25 8 5 stringent stringent JJ cord-024189-t7mbsr25 8 6 tissue tissue NN cord-024189-t7mbsr25 8 7 tropism tropism NN cord-024189-t7mbsr25 8 8 and and CC cord-024189-t7mbsr25 8 9 affect affect NN cord-024189-t7mbsr25 8 10 defined define VBN cord-024189-t7mbsr25 8 11 vascular vascular JJ cord-024189-t7mbsr25 8 12 territories territory NNS cord-024189-t7mbsr25 8 13 in in IN cord-024189-t7mbsr25 8 14 a a DT cord-024189-t7mbsr25 8 15 preferential preferential JJ cord-024189-t7mbsr25 8 16 manner manner NN cord-024189-t7mbsr25 8 17 . . . cord-024189-t7mbsr25 9 1 GCA GCA NNP cord-024189-t7mbsr25 9 2 predominantly predominantly RB cord-024189-t7mbsr25 9 3 affects affect VBZ cord-024189-t7mbsr25 9 4 the the DT cord-024189-t7mbsr25 9 5 second- second- NN cord-024189-t7mbsr25 9 6 to to IN cord-024189-t7mbsr25 9 7 fifth fifth JJ cord-024189-t7mbsr25 9 8 - - HYPH cord-024189-t7mbsr25 9 9 order order NN cord-024189-t7mbsr25 9 10 aortic aortic JJ cord-024189-t7mbsr25 9 11 branches branch NNS cord-024189-t7mbsr25 9 12 , , , cord-024189-t7mbsr25 9 13 often often RB cord-024189-t7mbsr25 9 14 in in IN cord-024189-t7mbsr25 9 15 the the DT cord-024189-t7mbsr25 9 16 extracranial extracranial JJ cord-024189-t7mbsr25 9 17 arteries artery NNS cord-024189-t7mbsr25 9 18 of of IN cord-024189-t7mbsr25 9 19 the the DT cord-024189-t7mbsr25 9 20 head head NN cord-024189-t7mbsr25 9 21 . . . cord-024189-t7mbsr25 10 1 The the DT cord-024189-t7mbsr25 10 2 aorta aorta NN cord-024189-t7mbsr25 10 3 itself -PRON- PRP cord-024189-t7mbsr25 10 4 may may MD cord-024189-t7mbsr25 10 5 also also RB cord-024189-t7mbsr25 10 6 be be VB cord-024189-t7mbsr25 10 7 affected affect VBN cord-024189-t7mbsr25 10 8 in in IN cord-024189-t7mbsr25 10 9 GCA GCA NNP cord-024189-t7mbsr25 10 10 , , , cord-024189-t7mbsr25 10 11 albeit albeit IN cord-024189-t7mbsr25 10 12 less less RBR cord-024189-t7mbsr25 10 13 often often RB cord-024189-t7mbsr25 10 14 than than IN cord-024189-t7mbsr25 10 15 other other JJ cord-024189-t7mbsr25 10 16 regions region NNS cord-024189-t7mbsr25 10 17 . . . cord-024189-t7mbsr25 11 1 In in IN cord-024189-t7mbsr25 11 2 contrast contrast NN cord-024189-t7mbsr25 11 3 , , , cord-024189-t7mbsr25 11 4 in in IN cord-024189-t7mbsr25 11 5 TA TA NNP cord-024189-t7mbsr25 11 6 , , , cord-024189-t7mbsr25 11 7 the the DT cord-024189-t7mbsr25 11 8 aorta aorta NN cord-024189-t7mbsr25 11 9 and and CC cord-024189-t7mbsr25 11 10 its -PRON- PRP$ cord-024189-t7mbsr25 11 11 major major JJ cord-024189-t7mbsr25 11 12 branches branch NNS cord-024189-t7mbsr25 11 13 are be VBP cord-024189-t7mbsr25 11 14 the the DT cord-024189-t7mbsr25 11 15 prime prime JJ cord-024189-t7mbsr25 11 16 disease disease NN cord-024189-t7mbsr25 11 17 targets target NNS cord-024189-t7mbsr25 11 18 . . . cord-024189-t7mbsr25 12 1 Despite despite IN cord-024189-t7mbsr25 12 2 the the DT cord-024189-t7mbsr25 12 3 spatial spatial JJ cord-024189-t7mbsr25 12 4 closeness closeness NN cord-024189-t7mbsr25 12 5 of of IN cord-024189-t7mbsr25 12 6 blood blood NN cord-024189-t7mbsr25 12 7 vessels vessel NNS cord-024189-t7mbsr25 12 8 and and CC cord-024189-t7mbsr25 12 9 infl infl NNP cord-024189-t7mbsr25 12 10 ammatory ammatory NNP cord-024189-t7mbsr25 12 11 cells cell NNS cord-024189-t7mbsr25 12 12 , , , cord-024189-t7mbsr25 12 13 blood blood NN cord-024189-t7mbsr25 12 14 vessel vessel NN cord-024189-t7mbsr25 12 15 walls wall NNS cord-024189-t7mbsr25 12 16 are be VBP cord-024189-t7mbsr25 12 17 infrequently infrequently RB cord-024189-t7mbsr25 12 18 targeted target VBN cord-024189-t7mbsr25 12 19 by by IN cord-024189-t7mbsr25 12 20 infl infl NNP cord-024189-t7mbsr25 12 21 ammation ammation NNP cord-024189-t7mbsr25 12 22 . . . cord-024189-t7mbsr25 13 1 Giant giant JJ cord-024189-t7mbsr25 13 2 cell cell NN cord-024189-t7mbsr25 13 3 arteritis arteritis NN cord-024189-t7mbsr25 13 4 ( ( -LRB- cord-024189-t7mbsr25 13 5 GCA GCA NNP cord-024189-t7mbsr25 13 6 ) ) -RRB- cord-024189-t7mbsr25 13 7 and and CC cord-024189-t7mbsr25 13 8 Takayasu Takayasu NNP cord-024189-t7mbsr25 13 9 's 's POS cord-024189-t7mbsr25 13 10 arteritis arteritis NN cord-024189-t7mbsr25 13 11 ( ( -LRB- cord-024189-t7mbsr25 13 12 TA TA NNP cord-024189-t7mbsr25 13 13 ) ) -RRB- cord-024189-t7mbsr25 13 14 are be VBP cord-024189-t7mbsr25 13 15 characterized characterize VBN cord-024189-t7mbsr25 13 16 by by IN cord-024189-t7mbsr25 13 17 infl infl NNP cord-024189-t7mbsr25 13 18 ammation ammation NNP cord-024189-t7mbsr25 13 19 directed direct VBN cord-024189-t7mbsr25 13 20 against against IN cord-024189-t7mbsr25 13 21 the the DT cord-024189-t7mbsr25 13 22 vessel vessel NN cord-024189-t7mbsr25 13 23 wall wall NN cord-024189-t7mbsr25 13 24 . . . cord-024189-t7mbsr25 14 1 GCA GCA NNP cord-024189-t7mbsr25 14 2 and and CC cord-024189-t7mbsr25 14 3 TA TA NNP cord-024189-t7mbsr25 14 4 display display VB cord-024189-t7mbsr25 14 5 stringent stringent JJ cord-024189-t7mbsr25 14 6 tissue tissue NN cord-024189-t7mbsr25 14 7 tropism tropism NN cord-024189-t7mbsr25 14 8 and and CC cord-024189-t7mbsr25 14 9 affect affect VB cord-024189-t7mbsr25 14 10 defi defi NNP cord-024189-t7mbsr25 14 11 ned ned NNP cord-024189-t7mbsr25 14 12 vascular vascular JJ cord-024189-t7mbsr25 14 13 territories territory NNS cord-024189-t7mbsr25 14 14 in in IN cord-024189-t7mbsr25 14 15 a a DT cord-024189-t7mbsr25 14 16 preferential preferential JJ cord-024189-t7mbsr25 14 17 manner manner NN cord-024189-t7mbsr25 14 18 . . . cord-024189-t7mbsr25 15 1 GCA GCA NNP cord-024189-t7mbsr25 15 2 predominantly predominantly RB cord-024189-t7mbsr25 15 3 affects affect VBZ cord-024189-t7mbsr25 15 4 the the DT cord-024189-t7mbsr25 15 5 second second JJ cord-024189-t7mbsr25 15 6 - - HYPH cord-024189-t7mbsr25 15 7 to to TO cord-024189-t7mbsr25 15 8 fi fi NNP cord-024189-t7mbsr25 15 9 fth fth JJ cord-024189-t7mbsr25 15 10 - - HYPH cord-024189-t7mbsr25 15 11 order order NN cord-024189-t7mbsr25 15 12 aortic aortic JJ cord-024189-t7mbsr25 15 13 branches branch NNS cord-024189-t7mbsr25 15 14 , , , cord-024189-t7mbsr25 15 15 often often RB cord-024189-t7mbsr25 15 16 in in IN cord-024189-t7mbsr25 15 17 the the DT cord-024189-t7mbsr25 15 18 extracranial extracranial JJ cord-024189-t7mbsr25 15 19 arteries artery NNS cord-024189-t7mbsr25 15 20 of of IN cord-024189-t7mbsr25 15 21 the the DT cord-024189-t7mbsr25 15 22 head head NN cord-024189-t7mbsr25 15 23 . . . cord-024189-t7mbsr25 16 1 The the DT cord-024189-t7mbsr25 16 2 aorta aorta NN cord-024189-t7mbsr25 16 3 itself -PRON- PRP cord-024189-t7mbsr25 16 4 may may MD cord-024189-t7mbsr25 16 5 also also RB cord-024189-t7mbsr25 16 6 be be VB cord-024189-t7mbsr25 16 7 affected affect VBN cord-024189-t7mbsr25 16 8 in in IN cord-024189-t7mbsr25 16 9 GCA GCA NNP cord-024189-t7mbsr25 16 10 , , , cord-024189-t7mbsr25 16 11 albeit albeit IN cord-024189-t7mbsr25 16 12 less less RBR cord-024189-t7mbsr25 16 13 often often RB cord-024189-t7mbsr25 16 14 than than IN cord-024189-t7mbsr25 16 15 other other JJ cord-024189-t7mbsr25 16 16 regions region NNS cord-024189-t7mbsr25 16 17 . . . cord-024189-t7mbsr25 17 1 In in IN cord-024189-t7mbsr25 17 2 contrast contrast NN cord-024189-t7mbsr25 17 3 , , , cord-024189-t7mbsr25 17 4 in in IN cord-024189-t7mbsr25 17 5 TA TA NNP cord-024189-t7mbsr25 17 6 , , , cord-024189-t7mbsr25 17 7 the the DT cord-024189-t7mbsr25 17 8 aorta aorta NN cord-024189-t7mbsr25 17 9 and and CC cord-024189-t7mbsr25 17 10 its -PRON- PRP$ cord-024189-t7mbsr25 17 11 major major JJ cord-024189-t7mbsr25 17 12 branches branch NNS cord-024189-t7mbsr25 17 13 are be VBP cord-024189-t7mbsr25 17 14 the the DT cord-024189-t7mbsr25 17 15 prime prime JJ cord-024189-t7mbsr25 17 16 disease disease NN cord-024189-t7mbsr25 17 17 targets target NNS cord-024189-t7mbsr25 17 18 . . . cord-024189-t7mbsr25 18 1 In in IN cord-024189-t7mbsr25 18 2 both both DT cord-024189-t7mbsr25 18 3 GCA GCA NNP cord-024189-t7mbsr25 18 4 and and CC cord-024189-t7mbsr25 18 5 TA TA NNP cord-024189-t7mbsr25 18 6 , , , cord-024189-t7mbsr25 18 7 clinical clinical JJ cord-024189-t7mbsr25 18 8 symptoms symptom NNS cord-024189-t7mbsr25 18 9 of of IN cord-024189-t7mbsr25 18 10 vascular vascular JJ cord-024189-t7mbsr25 18 11 infl infl NN cord-024189-t7mbsr25 18 12 ammation ammation NN cord-024189-t7mbsr25 18 13 and and CC cord-024189-t7mbsr25 18 14 vascular vascular JJ cord-024189-t7mbsr25 18 15 insuffi insuffi NNP cord-024189-t7mbsr25 18 16 ciency ciency NN cord-024189-t7mbsr25 18 17 are be VBP cord-024189-t7mbsr25 18 18 usually usually RB cord-024189-t7mbsr25 18 19 accompanied accompany VBN cord-024189-t7mbsr25 18 20 or or CC cord-024189-t7mbsr25 18 21 preceded precede VBN cord-024189-t7mbsr25 18 22 by by IN cord-024189-t7mbsr25 18 23 a a DT cord-024189-t7mbsr25 18 24 systemic systemic JJ cord-024189-t7mbsr25 18 25 infl infl NN cord-024189-t7mbsr25 18 26 ammatory ammatory NN cord-024189-t7mbsr25 18 27 process process NN cord-024189-t7mbsr25 18 28 not not RB cord-024189-t7mbsr25 18 29 localizable localizable JJ cord-024189-t7mbsr25 18 30 to to IN cord-024189-t7mbsr25 18 31 a a DT cord-024189-t7mbsr25 18 32 single single JJ cord-024189-t7mbsr25 18 33 tissue tissue NN cord-024189-t7mbsr25 18 34 or or CC cord-024189-t7mbsr25 18 35 organ organ NN cord-024189-t7mbsr25 18 36 . . . cord-024189-t7mbsr25 19 1 Systemic systemic JJ cord-024189-t7mbsr25 19 2 infl infl NN cord-024189-t7mbsr25 19 3 ammation ammation NN cord-024189-t7mbsr25 19 4 is be VBZ cord-024189-t7mbsr25 19 5 also also RB cord-024189-t7mbsr25 19 6 characteristic characteristic JJ cord-024189-t7mbsr25 19 7 of of IN cord-024189-t7mbsr25 19 8 polymyalgia polymyalgia NNP cord-024189-t7mbsr25 19 9 rheumatica rheumatica NNP cord-024189-t7mbsr25 19 10 ( ( -LRB- cord-024189-t7mbsr25 19 11 PMR PMR NNP cord-024189-t7mbsr25 19 12 ) ) -RRB- cord-024189-t7mbsr25 19 13 , , , cord-024189-t7mbsr25 19 14 a a DT cord-024189-t7mbsr25 19 15 syndrome syndrome NN cord-024189-t7mbsr25 19 16 of of IN cord-024189-t7mbsr25 19 17 muscle muscle NN cord-024189-t7mbsr25 19 18 pain pain NN cord-024189-t7mbsr25 19 19 and and CC cord-024189-t7mbsr25 19 20 stiffness stiffness NN cord-024189-t7mbsr25 19 21 in in IN cord-024189-t7mbsr25 19 22 the the DT cord-024189-t7mbsr25 19 23 neck neck NN cord-024189-t7mbsr25 19 24 , , , cord-024189-t7mbsr25 19 25 shoulders shoulder NNS cord-024189-t7mbsr25 19 26 , , , cord-024189-t7mbsr25 19 27 and and CC cord-024189-t7mbsr25 19 28 hips hip NNS cord-024189-t7mbsr25 19 29 . . . cord-024189-t7mbsr25 20 1 PMR PMR NNP cord-024189-t7mbsr25 20 2 can can MD cord-024189-t7mbsr25 20 3 accompany accompany VB cord-024189-t7mbsr25 20 4 , , , cord-024189-t7mbsr25 20 5 precede precede VB cord-024189-t7mbsr25 20 6 , , , cord-024189-t7mbsr25 20 7 or or CC cord-024189-t7mbsr25 20 8 follow follow VB cord-024189-t7mbsr25 20 9 GCA GCA NNP cord-024189-t7mbsr25 20 10 , , , cord-024189-t7mbsr25 20 11 but but CC cord-024189-t7mbsr25 20 12 it -PRON- PRP cord-024189-t7mbsr25 20 13 also also RB cord-024189-t7mbsr25 20 14 occurs occur VBZ cord-024189-t7mbsr25 20 15 independently independently RB cord-024189-t7mbsr25 20 16 . . . cord-024189-t7mbsr25 21 1 In in IN cord-024189-t7mbsr25 21 2 a a DT cord-024189-t7mbsr25 21 3 subset subset NN cord-024189-t7mbsr25 21 4 of of IN cord-024189-t7mbsr25 21 5 PMR PMR NNP cord-024189-t7mbsr25 21 6 patients patient NNS cord-024189-t7mbsr25 21 7 , , , cord-024189-t7mbsr25 21 8 GCA GCA NNP cord-024189-t7mbsr25 21 9 is be VBZ cord-024189-t7mbsr25 21 10 present present JJ cord-024189-t7mbsr25 21 11 but but CC cord-024189-t7mbsr25 21 12 not not RB cord-024189-t7mbsr25 21 13 clinically clinically RB cord-024189-t7mbsr25 21 14 evident evident JJ cord-024189-t7mbsr25 21 15 . . . cord-024189-t7mbsr25 22 1 Giant giant JJ cord-024189-t7mbsr25 22 2 cell cell NN cord-024189-t7mbsr25 22 3 arteritis arteritis NN cord-024189-t7mbsr25 22 4 is be VBZ cord-024189-t7mbsr25 22 5 the the DT cord-024189-t7mbsr25 22 6 most most RBS cord-024189-t7mbsr25 22 7 common common JJ cord-024189-t7mbsr25 22 8 primary primary JJ cord-024189-t7mbsr25 22 9 form form NN cord-024189-t7mbsr25 22 10 of of IN cord-024189-t7mbsr25 22 11 vasculitis vasculitis NN cord-024189-t7mbsr25 22 12 among among IN cord-024189-t7mbsr25 22 13 adults adult NNS cord-024189-t7mbsr25 22 14 in in IN cord-024189-t7mbsr25 22 15 the the DT cord-024189-t7mbsr25 22 16 United United NNP cord-024189-t7mbsr25 22 17 States States NNP cord-024189-t7mbsr25 22 18 and and CC cord-024189-t7mbsr25 22 19 Europe Europe NNP cord-024189-t7mbsr25 22 20 . . . cord-024189-t7mbsr25 23 1 The the DT cord-024189-t7mbsr25 23 2 disease disease NN cord-024189-t7mbsr25 23 3 occurs occur VBZ cord-024189-t7mbsr25 23 4 almost almost RB cord-024189-t7mbsr25 23 5 exclusively exclusively RB cord-024189-t7mbsr25 23 6 in in IN cord-024189-t7mbsr25 23 7 individuals individual NNS cord-024189-t7mbsr25 23 8 aged age VBN cord-024189-t7mbsr25 23 9 50 50 CD cord-024189-t7mbsr25 23 10 years year NNS cord-024189-t7mbsr25 23 11 and and CC cord-024189-t7mbsr25 23 12 older old JJR cord-024189-t7mbsr25 23 13 , , , cord-024189-t7mbsr25 23 14 and and CC cord-024189-t7mbsr25 23 15 its -PRON- PRP$ cord-024189-t7mbsr25 23 16 incidence incidence NN cord-024189-t7mbsr25 23 17 increases increase VBZ cord-024189-t7mbsr25 23 18 progressively progressively RB cord-024189-t7mbsr25 23 19 with with IN cord-024189-t7mbsr25 23 20 age age NN cord-024189-t7mbsr25 23 21 ( ( -LRB- cord-024189-t7mbsr25 23 22 1 1 CD cord-024189-t7mbsr25 23 23 ) ) -RRB- cord-024189-t7mbsr25 23 24 . . . cord-024189-t7mbsr25 24 1 Women woman NNS cord-024189-t7mbsr25 24 2 are be VBP cord-024189-t7mbsr25 24 3 more more RBR cord-024189-t7mbsr25 24 4 likely likely JJ cord-024189-t7mbsr25 24 5 to to TO cord-024189-t7mbsr25 24 6 be be VB cord-024189-t7mbsr25 24 7 affected affect VBN cord-024189-t7mbsr25 24 8 than than IN cord-024189-t7mbsr25 24 9 men man NNS cord-024189-t7mbsr25 24 10 . . . cord-024189-t7mbsr25 25 1 The the DT cord-024189-t7mbsr25 25 2 prevalence prevalence NN cord-024189-t7mbsr25 25 3 is be VBZ cord-024189-t7mbsr25 25 4 highest high JJS cord-024189-t7mbsr25 25 5 in in IN cord-024189-t7mbsr25 25 6 Scandi Scandi NNP cord-024189-t7mbsr25 25 7 - - HYPH cord-024189-t7mbsr25 25 8 navian navian JJ cord-024189-t7mbsr25 25 9 countries country NNS cord-024189-t7mbsr25 25 10 and and CC cord-024189-t7mbsr25 25 11 in in IN cord-024189-t7mbsr25 25 12 regions region NNS cord-024189-t7mbsr25 25 13 settled settle VBN cord-024189-t7mbsr25 25 14 by by IN cord-024189-t7mbsr25 25 15 people people NNS cord-024189-t7mbsr25 25 16 of of IN cord-024189-t7mbsr25 25 17 Northern northern JJ cord-024189-t7mbsr25 25 18 European european JJ cord-024189-t7mbsr25 25 19 descent descent NN cord-024189-t7mbsr25 25 20 , , , cord-024189-t7mbsr25 25 21 with with IN cord-024189-t7mbsr25 25 22 incidence incidence NN cord-024189-t7mbsr25 25 23 rates rate NNS cord-024189-t7mbsr25 25 24 reaching reach VBG cord-024189-t7mbsr25 25 25 15 15 CD cord-024189-t7mbsr25 25 26 to to TO cord-024189-t7mbsr25 25 27 25 25 CD cord-024189-t7mbsr25 25 28 cases case NNS cord-024189-t7mbsr25 25 29 per per IN cord-024189-t7mbsr25 25 30 100,000 100,000 CD cord-024189-t7mbsr25 25 31 persons person NNS cord-024189-t7mbsr25 25 32 aged age VBN cord-024189-t7mbsr25 25 33 50 50 CD cord-024189-t7mbsr25 25 34 years year NNS cord-024189-t7mbsr25 25 35 and and CC cord-024189-t7mbsr25 25 36 older old JJR cord-024189-t7mbsr25 25 37 . . . cord-024189-t7mbsr25 26 1 GCA GCA NNP cord-024189-t7mbsr25 26 2 occurs occur VBZ cord-024189-t7mbsr25 26 3 much much RB cord-024189-t7mbsr25 26 4 less less RBR cord-024189-t7mbsr25 26 5 frequently frequently RB cord-024189-t7mbsr25 26 6 in in IN cord-024189-t7mbsr25 26 7 Southern southern JJ cord-024189-t7mbsr25 26 8 Europeans Europeans NNPS cord-024189-t7mbsr25 26 9 ( ( -LRB- cord-024189-t7mbsr25 26 10 6 6 CD cord-024189-t7mbsr25 26 11 cases case NNS cord-024189-t7mbsr25 26 12 per per IN cord-024189-t7mbsr25 26 13 100,000 100,000 CD cord-024189-t7mbsr25 26 14 individuals individual NNS cord-024189-t7mbsr25 26 15 ) ) -RRB- cord-024189-t7mbsr25 26 16 and and CC cord-024189-t7mbsr25 26 17 is be VBZ cord-024189-t7mbsr25 26 18 rare rare JJ cord-024189-t7mbsr25 26 19 in in IN cord-024189-t7mbsr25 26 20 blacks black NNS cord-024189-t7mbsr25 26 21 and and CC cord-024189-t7mbsr25 26 22 Hispanics Hispanics NNPS cord-024189-t7mbsr25 26 23 ( ( -LRB- cord-024189-t7mbsr25 26 24 1 1 CD cord-024189-t7mbsr25 26 25 - - SYM cord-024189-t7mbsr25 26 26 2 2 CD cord-024189-t7mbsr25 26 27 cases case NNS cord-024189-t7mbsr25 26 28 per per IN cord-024189-t7mbsr25 26 29 100,000 100,000 CD cord-024189-t7mbsr25 26 30 individuals individual NNS cord-024189-t7mbsr25 26 31 ) ) -RRB- cord-024189-t7mbsr25 26 32 . . . cord-024189-t7mbsr25 27 1 The the DT cord-024189-t7mbsr25 27 2 histological histological JJ cord-024189-t7mbsr25 27 3 hallmark hallmark NN cord-024189-t7mbsr25 27 4 of of IN cord-024189-t7mbsr25 27 5 GCA GCA NNP cord-024189-t7mbsr25 27 6 is be VBZ cord-024189-t7mbsr25 27 7 a a DT cord-024189-t7mbsr25 27 8 mononuclear mononuclear JJ cord-024189-t7mbsr25 27 9 cell cell NN cord-024189-t7mbsr25 27 10 infi infi NNP cord-024189-t7mbsr25 27 11 ltrate ltrate NNP cord-024189-t7mbsr25 27 12 dominated dominate VBN cord-024189-t7mbsr25 27 13 by by IN cord-024189-t7mbsr25 27 14 T T NNP cord-024189-t7mbsr25 27 15 lymphocytes lymphocyte NNS cord-024189-t7mbsr25 27 16 and and CC cord-024189-t7mbsr25 27 17 macrophages macrophage NNS cord-024189-t7mbsr25 27 18 . . . cord-024189-t7mbsr25 28 1 The the DT cord-024189-t7mbsr25 28 2 infl infl NNP cord-024189-t7mbsr25 28 3 ammatory ammatory NNP cord-024189-t7mbsr25 28 4 infi infi NNP cord-024189-t7mbsr25 28 5 ltrate ltrate NNP cord-024189-t7mbsr25 28 6 penetrates penetrate VBZ cord-024189-t7mbsr25 28 7 all all DT cord-024189-t7mbsr25 28 8 layers layer NNS cord-024189-t7mbsr25 28 9 of of IN cord-024189-t7mbsr25 28 10 the the DT cord-024189-t7mbsr25 28 11 arterial arterial JJ cord-024189-t7mbsr25 28 12 wall wall NN cord-024189-t7mbsr25 28 13 ( ( -LRB- cord-024189-t7mbsr25 28 14 Figure Figure NNP cord-024189-t7mbsr25 28 15 21A-1 21a-1 CD cord-024189-t7mbsr25 28 16 ) ) -RRB- cord-024189-t7mbsr25 28 17 . . . cord-024189-t7mbsr25 29 1 The the DT cord-024189-t7mbsr25 29 2 infi infi NNP cord-024189-t7mbsr25 29 3 ltrates ltrates NNP cord-024189-t7mbsr25 29 4 can can MD cord-024189-t7mbsr25 29 5 be be VB cord-024189-t7mbsr25 29 6 granulomatous granulomatous JJ cord-024189-t7mbsr25 29 7 with with IN cord-024189-t7mbsr25 29 8 the the DT cord-024189-t7mbsr25 29 9 accumulation accumulation NN cord-024189-t7mbsr25 29 10 of of IN cord-024189-t7mbsr25 29 11 histiocytes histiocyte NNS cord-024189-t7mbsr25 29 12 and and CC cord-024189-t7mbsr25 29 13 multinucleated multinucleate VBN cord-024189-t7mbsr25 29 14 giant giant JJ cord-024189-t7mbsr25 29 15 cells cell NNS cord-024189-t7mbsr25 29 16 . . . cord-024189-t7mbsr25 30 1 Granuloma Granuloma NNP cord-024189-t7mbsr25 30 2 formation formation NN cord-024189-t7mbsr25 30 3 is be VBZ cord-024189-t7mbsr25 30 4 most most RBS cord-024189-t7mbsr25 30 5 likely likely JJ cord-024189-t7mbsr25 30 6 to to TO cord-024189-t7mbsr25 30 7 be be VB cord-024189-t7mbsr25 30 8 observed observe VBN cord-024189-t7mbsr25 30 9 in in IN cord-024189-t7mbsr25 30 10 the the DT cord-024189-t7mbsr25 30 11 media medium NNS cord-024189-t7mbsr25 30 12 . . . cord-024189-t7mbsr25 31 1 Although although IN cord-024189-t7mbsr25 31 2 the the DT cord-024189-t7mbsr25 31 3 presence presence NN cord-024189-t7mbsr25 31 4 of of IN cord-024189-t7mbsr25 31 5 multinucleated multinucleate VBN cord-024189-t7mbsr25 31 6 giant giant JJ cord-024189-t7mbsr25 31 7 cells cell NNS cord-024189-t7mbsr25 31 8 inspired inspire VBD cord-024189-t7mbsr25 31 9 the the DT cord-024189-t7mbsr25 31 10 name name NN cord-024189-t7mbsr25 31 11 of of IN cord-024189-t7mbsr25 31 12 the the DT cord-024189-t7mbsr25 31 13 disease disease NN cord-024189-t7mbsr25 31 14 , , , cord-024189-t7mbsr25 31 15 they -PRON- PRP cord-024189-t7mbsr25 31 16 are be VBP cord-024189-t7mbsr25 31 17 often often RB cord-024189-t7mbsr25 31 18 absent absent JJ cord-024189-t7mbsr25 31 19 , , , cord-024189-t7mbsr25 31 20 and and CC cord-024189-t7mbsr25 31 21 the the DT cord-024189-t7mbsr25 31 22 mononuclear mononuclear NNP cord-024189-t7mbsr25 31 23 infi infi NNP cord-024189-t7mbsr25 31 24 ltrates ltrates NNP cord-024189-t7mbsr25 31 25 lack lack VBP cord-024189-t7mbsr25 31 26 a a DT cord-024189-t7mbsr25 31 27 complex complex JJ cord-024189-t7mbsr25 31 28 organization organization NN cord-024189-t7mbsr25 31 29 . . . cord-024189-t7mbsr25 32 1 If if IN cord-024189-t7mbsr25 32 2 present present JJ cord-024189-t7mbsr25 32 3 , , , cord-024189-t7mbsr25 32 4 giant giant JJ cord-024189-t7mbsr25 32 5 cells cell NNS cord-024189-t7mbsr25 32 6 lie lie VBP cord-024189-t7mbsr25 32 7 in in IN cord-024189-t7mbsr25 32 8 close close JJ cord-024189-t7mbsr25 32 9 proximity proximity NN cord-024189-t7mbsr25 32 10 to to IN cord-024189-t7mbsr25 32 11 the the DT cord-024189-t7mbsr25 32 12 fragmented fragmented JJ cord-024189-t7mbsr25 32 13 internal internal JJ cord-024189-t7mbsr25 32 14 elastic elastic JJ cord-024189-t7mbsr25 32 15 lamina lamina NN cord-024189-t7mbsr25 32 16 . . . cord-024189-t7mbsr25 33 1 Their -PRON- PRP$ cord-024189-t7mbsr25 33 2 presence presence NN cord-024189-t7mbsr25 33 3 correlates correlate VBZ cord-024189-t7mbsr25 33 4 with with IN cord-024189-t7mbsr25 33 5 increased increase VBN cord-024189-t7mbsr25 33 6 risk risk NN cord-024189-t7mbsr25 33 7 for for IN cord-024189-t7mbsr25 33 8 ischemic ischemic JJ cord-024189-t7mbsr25 33 9 complications complication NNS cord-024189-t7mbsr25 33 10 . . . cord-024189-t7mbsr25 34 1 GCA GCA NNP cord-024189-t7mbsr25 34 2 can can MD cord-024189-t7mbsr25 34 3 also also RB cord-024189-t7mbsr25 34 4 present present VB cord-024189-t7mbsr25 34 5 with with IN cord-024189-t7mbsr25 34 6 perivascular perivascular NNP cord-024189-t7mbsr25 34 7 cuffi cuffi NNP cord-024189-t7mbsr25 34 8 ng ng NNP cord-024189-t7mbsr25 34 9 of of IN cord-024189-t7mbsr25 34 10 vasa vasa NNP cord-024189-t7mbsr25 34 11 vasorum vasorum NNP cord-024189-t7mbsr25 34 12 or or CC cord-024189-t7mbsr25 34 13 T T NNP cord-024189-t7mbsr25 34 14 cell cell NN cord-024189-t7mbsr25 34 15 - - HYPH cord-024189-t7mbsr25 34 16 macrophage macrophage NN cord-024189-t7mbsr25 34 17 infi infi NNP cord-024189-t7mbsr25 34 18 ltrates ltrates NNP cord-024189-t7mbsr25 34 19 in in IN cord-024189-t7mbsr25 34 20 the the DT cord-024189-t7mbsr25 34 21 adventitia adventitia NN cord-024189-t7mbsr25 34 22 , , , cord-024189-t7mbsr25 34 23 sometimes sometimes RB cord-024189-t7mbsr25 34 24 arranged arrange VBN cord-024189-t7mbsr25 34 25 along along IN cord-024189-t7mbsr25 34 26 the the DT cord-024189-t7mbsr25 34 27 external external JJ cord-024189-t7mbsr25 34 28 elastic elastic JJ cord-024189-t7mbsr25 34 29 lamina lamina NN cord-024189-t7mbsr25 34 30 . . . cord-024189-t7mbsr25 35 1 This this DT cord-024189-t7mbsr25 35 2 fi fi NN cord-024189-t7mbsr25 35 3 nding nding NN cord-024189-t7mbsr25 35 4 is be VBZ cord-024189-t7mbsr25 35 5 consistent consistent JJ cord-024189-t7mbsr25 35 6 with with IN cord-024189-t7mbsr25 35 7 recent recent JJ cord-024189-t7mbsr25 35 8 studies study NNS cord-024189-t7mbsr25 35 9 suggesting suggest VBG cord-024189-t7mbsr25 35 10 that that IN cord-024189-t7mbsr25 35 11 the the DT cord-024189-t7mbsr25 35 12 adventitia adventitia NN cord-024189-t7mbsr25 35 13 is be VBZ cord-024189-t7mbsr25 35 14 a a DT cord-024189-t7mbsr25 35 15 critical critical JJ cord-024189-t7mbsr25 35 16 site site NN cord-024189-t7mbsr25 35 17 in in IN cord-024189-t7mbsr25 35 18 the the DT cord-024189-t7mbsr25 35 19 disease disease NN cord-024189-t7mbsr25 35 20 process process NN cord-024189-t7mbsr25 35 21 . . . cord-024189-t7mbsr25 36 1 The the DT cord-024189-t7mbsr25 36 2 infl infl NN cord-024189-t7mbsr25 36 3 ammation ammation NN cord-024189-t7mbsr25 36 4 causes cause VBZ cord-024189-t7mbsr25 36 5 a a DT cord-024189-t7mbsr25 36 6 series series NN cord-024189-t7mbsr25 36 7 of of IN cord-024189-t7mbsr25 36 8 structural structural JJ cord-024189-t7mbsr25 36 9 changes change NNS cord-024189-t7mbsr25 36 10 to to IN cord-024189-t7mbsr25 36 11 the the DT cord-024189-t7mbsr25 36 12 arterial arterial JJ cord-024189-t7mbsr25 36 13 wall wall NN cord-024189-t7mbsr25 36 14 . . . cord-024189-t7mbsr25 37 1 Among among IN cord-024189-t7mbsr25 37 2 the the DT cord-024189-t7mbsr25 37 3 fi fi NN cord-024189-t7mbsr25 37 4 rst rst FW cord-024189-t7mbsr25 37 5 pathologic pathologic JJ cord-024189-t7mbsr25 37 6 changes change NNS cord-024189-t7mbsr25 37 7 observed observe VBN cord-024189-t7mbsr25 37 8 is be VBZ cord-024189-t7mbsr25 37 9 the the DT cord-024189-t7mbsr25 37 10 fi fi NNP cord-024189-t7mbsr25 37 11 nding nding NN cord-024189-t7mbsr25 37 12 of of IN cord-024189-t7mbsr25 37 13 a a DT cord-024189-t7mbsr25 37 14 lymphoplasmacytic lymphoplasmacytic NNP cord-024189-t7mbsr25 37 15 infi infi NNP cord-024189-t7mbsr25 37 16 ltrate ltrate NNP cord-024189-t7mbsr25 37 17 in in IN cord-024189-t7mbsr25 37 18 the the DT cord-024189-t7mbsr25 37 19 adventitia adventitia NN cord-024189-t7mbsr25 37 20 . . . cord-024189-t7mbsr25 38 1 With with IN cord-024189-t7mbsr25 38 2 progress progress NN cord-024189-t7mbsr25 38 3 of of IN cord-024189-t7mbsr25 38 4 the the DT cord-024189-t7mbsr25 38 5 infl infl NNP cord-024189-t7mbsr25 38 6 ammatory ammatory NNP cord-024189-t7mbsr25 38 7 process process NN cord-024189-t7mbsr25 38 8 , , , cord-024189-t7mbsr25 38 9 the the DT cord-024189-t7mbsr25 38 10 media medium NNS cord-024189-t7mbsr25 38 11 of of IN cord-024189-t7mbsr25 38 12 the the DT cord-024189-t7mbsr25 38 13 arterial arterial JJ cord-024189-t7mbsr25 38 14 wall wall NN cord-024189-t7mbsr25 38 15 becomes become VBZ cord-024189-t7mbsr25 38 16 thinner thin JJR cord-024189-t7mbsr25 38 17 . . . cord-024189-t7mbsr25 39 1 As as IN cord-024189-t7mbsr25 39 2 the the DT cord-024189-t7mbsr25 39 3 medial medial JJ cord-024189-t7mbsr25 39 4 smooth smooth JJ cord-024189-t7mbsr25 39 5 muscle muscle NN cord-024189-t7mbsr25 39 6 cell cell NN cord-024189-t7mbsr25 39 7 layer layer NN cord-024189-t7mbsr25 39 8 loses lose VBZ cord-024189-t7mbsr25 39 9 thickness thickness NN cord-024189-t7mbsr25 39 10 , , , cord-024189-t7mbsr25 39 11 the the DT cord-024189-t7mbsr25 39 12 intima intima NN cord-024189-t7mbsr25 39 13 becomes become VBZ cord-024189-t7mbsr25 39 14 hyperplastic hyperplastic JJ cord-024189-t7mbsr25 39 15 , , , cord-024189-t7mbsr25 39 16 compromising compromise VBG cord-024189-t7mbsr25 39 17 or or CC cord-024189-t7mbsr25 39 18 occluding occlude VBG cord-024189-t7mbsr25 39 19 the the DT cord-024189-t7mbsr25 39 20 arterial arterial JJ cord-024189-t7mbsr25 39 21 lumen lumen NN cord-024189-t7mbsr25 39 22 . . . cord-024189-t7mbsr25 40 1 Although although IN cord-024189-t7mbsr25 40 2 the the DT cord-024189-t7mbsr25 40 3 vessel vessel NN cord-024189-t7mbsr25 40 4 lumen lumen NN cord-024189-t7mbsr25 40 5 may may MD cord-024189-t7mbsr25 40 6 become become VB cord-024189-t7mbsr25 40 7 critically critically RB cord-024189-t7mbsr25 40 8 narrowed narrow VBN cord-024189-t7mbsr25 40 9 , , , cord-024189-t7mbsr25 40 10 thrombosis thrombosis NN cord-024189-t7mbsr25 40 11 is be VBZ cord-024189-t7mbsr25 40 12 not not RB cord-024189-t7mbsr25 40 13 the the DT cord-024189-t7mbsr25 40 14 central central JJ cord-024189-t7mbsr25 40 15 event event NN cord-024189-t7mbsr25 40 16 . . . cord-024189-t7mbsr25 41 1 Hyperplasia hyperplasia NN cord-024189-t7mbsr25 41 2 of of IN cord-024189-t7mbsr25 41 3 the the DT cord-024189-t7mbsr25 41 4 intimal intimal JJ cord-024189-t7mbsr25 41 5 layer layer NN cord-024189-t7mbsr25 41 6 with with IN cord-024189-t7mbsr25 41 7 scarring scarring NN cord-024189-t7mbsr25 41 8 in in IN cord-024189-t7mbsr25 41 9 the the DT cord-024189-t7mbsr25 41 10 media medium NNS cord-024189-t7mbsr25 41 11 and and CC cord-024189-t7mbsr25 41 12 fragmentation fragmentation NN cord-024189-t7mbsr25 41 13 of of IN cord-024189-t7mbsr25 41 14 the the DT cord-024189-t7mbsr25 41 15 elastic elastic JJ cord-024189-t7mbsr25 41 16 lamina lamina NN cord-024189-t7mbsr25 41 17 are be VBP cord-024189-t7mbsr25 41 18 irreversible irreversible JJ cord-024189-t7mbsr25 41 19 changes change NNS cord-024189-t7mbsr25 41 20 that that WDT cord-024189-t7mbsr25 41 21 persist persist VBP cord-024189-t7mbsr25 41 22 beyond beyond IN cord-024189-t7mbsr25 41 23 the the DT cord-024189-t7mbsr25 41 24 stages stage NNS cord-024189-t7mbsr25 41 25 of of IN cord-024189-t7mbsr25 41 26 active active JJ cord-024189-t7mbsr25 41 27 arterial arterial JJ cord-024189-t7mbsr25 41 28 infl infl NN cord-024189-t7mbsr25 41 29 ammation ammation NN cord-024189-t7mbsr25 41 30 . . . cord-024189-t7mbsr25 42 1 Fibrinoid fibrinoid JJ cord-024189-t7mbsr25 42 2 necrosis necrosis NN cord-024189-t7mbsr25 42 3 is be VBZ cord-024189-t7mbsr25 42 4 rare rare JJ cord-024189-t7mbsr25 42 5 and and CC cord-024189-t7mbsr25 42 6 should should MD cord-024189-t7mbsr25 42 7 raise raise VB cord-024189-t7mbsr25 42 8 the the DT cord-024189-t7mbsr25 42 9 suspicion suspicion NN cord-024189-t7mbsr25 42 10 for for IN cord-024189-t7mbsr25 42 11 other other JJ cord-024189-t7mbsr25 42 12 forms form NNS cord-024189-t7mbsr25 42 13 of of IN cord-024189-t7mbsr25 42 14 vasculitis vasculitis NN cord-024189-t7mbsr25 42 15 . . . cord-024189-t7mbsr25 43 1 Polyarteritis Polyarteritis NNP cord-024189-t7mbsr25 43 2 nodosa nodosa RB cord-024189-t7mbsr25 43 3 , , , cord-024189-t7mbsr25 43 4 microscopic microscopic JJ cord-024189-t7mbsr25 43 5 polyangiitis polyangiitis NN cord-024189-t7mbsr25 43 6 , , , cord-024189-t7mbsr25 43 7 and and CC cord-024189-t7mbsr25 43 8 Wegener Wegener NNP cord-024189-t7mbsr25 43 9 's 's POS cord-024189-t7mbsr25 43 10 granulomatosis granulomatosis NN cord-024189-t7mbsr25 43 11 , , , cord-024189-t7mbsr25 43 12 for for IN cord-024189-t7mbsr25 43 13 example example NN cord-024189-t7mbsr25 43 14 , , , cord-024189-t7mbsr25 43 15 are be VBP cord-024189-t7mbsr25 43 16 known know VBN cord-024189-t7mbsr25 43 17 to to TO cord-024189-t7mbsr25 43 18 affect affect VB cord-024189-t7mbsr25 43 19 the the DT cord-024189-t7mbsr25 43 20 temporal temporal JJ cord-024189-t7mbsr25 43 21 artery artery NN cord-024189-t7mbsr25 43 22 as as RB cord-024189-t7mbsr25 43 23 well well RB cord-024189-t7mbsr25 43 24 as as IN cord-024189-t7mbsr25 43 25 other other JJ cord-024189-t7mbsr25 43 26 more more RBR cord-024189-t7mbsr25 43 27 typical typical JJ cord-024189-t7mbsr25 43 28 vascular vascular JJ cord-024189-t7mbsr25 43 29 beds bed NNS cord-024189-t7mbsr25 43 30 . . . cord-024189-t7mbsr25 44 1 When when WRB cord-024189-t7mbsr25 44 2 these these DT cord-024189-t7mbsr25 44 3 forms form NNS cord-024189-t7mbsr25 44 4 of of IN cord-024189-t7mbsr25 44 5 vasculitis vasculitis NN cord-024189-t7mbsr25 44 6 affect affect VBP cord-024189-t7mbsr25 44 7 the the DT cord-024189-t7mbsr25 44 8 temporal temporal JJ cord-024189-t7mbsr25 44 9 artery artery NN cord-024189-t7mbsr25 44 10 , , , cord-024189-t7mbsr25 44 11 their -PRON- PRP$ cord-024189-t7mbsr25 44 12 fi fi NN cord-024189-t7mbsr25 44 13 rst rst NNP cord-024189-t7mbsr25 44 14 pathological pathological JJ cord-024189-t7mbsr25 44 15 manifestations manifestation NNS cord-024189-t7mbsr25 44 16 may may MD cord-024189-t7mbsr25 44 17 be be VB cord-024189-t7mbsr25 44 18 lymphoplasmacytic lymphoplasmacytic NNP cord-024189-t7mbsr25 44 19 infi infi NNP cord-024189-t7mbsr25 44 20 ltrates ltrates NNP cord-024189-t7mbsr25 44 21 within within IN cord-024189-t7mbsr25 44 22 the the DT cord-024189-t7mbsr25 44 23 adventitia adventitia NN cord-024189-t7mbsr25 44 24 , , , cord-024189-t7mbsr25 44 25 indistinguishable indistinguishable JJ cord-024189-t7mbsr25 44 26 at at IN cord-024189-t7mbsr25 44 27 an an DT cord-024189-t7mbsr25 44 28 early early JJ cord-024189-t7mbsr25 44 29 stage stage NN cord-024189-t7mbsr25 44 30 from from IN cord-024189-t7mbsr25 44 31 GCA GCA NNP cord-024189-t7mbsr25 44 32 . . . cord-024189-t7mbsr25 45 1 The the DT cord-024189-t7mbsr25 45 2 Immune Immune NNP cord-024189-t7mbsr25 45 3 Response response NN cord-024189-t7mbsr25 45 4 in in IN cord-024189-t7mbsr25 45 5 the the DT cord-024189-t7mbsr25 45 6 Arterial arterial JJ cord-024189-t7mbsr25 45 7 Wall Wall NNP cord-024189-t7mbsr25 45 8 Experimental experimental JJ cord-024189-t7mbsr25 45 9 evidence evidence NN cord-024189-t7mbsr25 45 10 supports support VBZ cord-024189-t7mbsr25 45 11 a a DT cord-024189-t7mbsr25 45 12 T t NN cord-024189-t7mbsr25 45 13 - - HYPH cord-024189-t7mbsr25 45 14 cell cell NN cord-024189-t7mbsr25 45 15 - - HYPH cord-024189-t7mbsr25 45 16 mediated mediate VBN cord-024189-t7mbsr25 45 17 immunopathology immunopathology NN cord-024189-t7mbsr25 45 18 of of IN cord-024189-t7mbsr25 45 19 GCA GCA NNP cord-024189-t7mbsr25 45 20 ( ( -LRB- cord-024189-t7mbsr25 45 21 2 2 CD cord-024189-t7mbsr25 45 22 ) ) -RRB- cord-024189-t7mbsr25 45 23 . . . cord-024189-t7mbsr25 46 1 Humoral humoral JJ cord-024189-t7mbsr25 46 2 immunity immunity NN cord-024189-t7mbsr25 46 3 does do VBZ cord-024189-t7mbsr25 46 4 not not RB cord-024189-t7mbsr25 46 5 appear appear VB cord-024189-t7mbsr25 46 6 to to TO cord-024189-t7mbsr25 46 7 be be VB cord-024189-t7mbsr25 46 8 important important JJ cord-024189-t7mbsr25 46 9 : : : cord-024189-t7mbsr25 46 10 B b NN cord-024189-t7mbsr25 46 11 cells cell NNS cord-024189-t7mbsr25 46 12 are be VBP cord-024189-t7mbsr25 46 13 not not RB cord-024189-t7mbsr25 46 14 found find VBN cord-024189-t7mbsr25 46 15 within within IN cord-024189-t7mbsr25 46 16 the the DT cord-024189-t7mbsr25 46 17 arterial arterial JJ cord-024189-t7mbsr25 46 18 wall wall NN cord-024189-t7mbsr25 46 19 ; ; : cord-024189-t7mbsr25 46 20 no no DT cord-024189-t7mbsr25 46 21 pathognomic pathognomic JJ cord-024189-t7mbsr25 46 22 antibodies antibody NNS cord-024189-t7mbsr25 46 23 have have VBP cord-024189-t7mbsr25 46 24 been be VBN cord-024189-t7mbsr25 46 25 identifi identifi VBN cord-024189-t7mbsr25 46 26 ed ed NN cord-024189-t7mbsr25 46 27 ; ; : cord-024189-t7mbsr25 46 28 and and CC cord-024189-t7mbsr25 46 29 hypergammaglobulinemia hypergammaglobulinemia NNP cord-024189-t7mbsr25 46 30 is be VBZ cord-024189-t7mbsr25 46 31 absent absent JJ cord-024189-t7mbsr25 46 32 . . . cord-024189-t7mbsr25 47 1 T T NNP cord-024189-t7mbsr25 47 2 cells cell NNS cord-024189-t7mbsr25 47 3 enter enter VBP cord-024189-t7mbsr25 47 4 the the DT cord-024189-t7mbsr25 47 5 vessel vessel NN cord-024189-t7mbsr25 47 6 wall wall NN cord-024189-t7mbsr25 47 7 from from IN cord-024189-t7mbsr25 47 8 the the DT cord-024189-t7mbsr25 47 9 vasa vasa NNP cord-024189-t7mbsr25 47 10 vasorum vasorum NNP cord-024189-t7mbsr25 47 11 in in IN cord-024189-t7mbsr25 47 12 the the DT cord-024189-t7mbsr25 47 13 adventitia adventitia NN cord-024189-t7mbsr25 47 14 , , , cord-024189-t7mbsr25 47 15 not not RB cord-024189-t7mbsr25 47 16 from from IN cord-024189-t7mbsr25 47 17 the the DT cord-024189-t7mbsr25 47 18 macroendothelium macroendothelium NN cord-024189-t7mbsr25 47 19 . . . cord-024189-t7mbsr25 48 1 Recruitment recruitment NN cord-024189-t7mbsr25 48 2 and and CC cord-024189-t7mbsr25 48 3 activation activation NN cord-024189-t7mbsr25 48 4 of of IN cord-024189-t7mbsr25 48 5 tissue tissue NN cord-024189-t7mbsr25 48 6 - - HYPH cord-024189-t7mbsr25 48 7 invading invade VBG cord-024189-t7mbsr25 48 8 T t NN cord-024189-t7mbsr25 48 9 cells cell NNS cord-024189-t7mbsr25 48 10 is be VBZ cord-024189-t7mbsr25 48 11 controlled control VBN cord-024189-t7mbsr25 48 12 by by IN cord-024189-t7mbsr25 48 13 dendritic dendritic JJ cord-024189-t7mbsr25 48 14 cells cell NNS cord-024189-t7mbsr25 48 15 ( ( -LRB- cord-024189-t7mbsr25 48 16 DCs DCs NNP cord-024189-t7mbsr25 48 17 ) ) -RRB- cord-024189-t7mbsr25 48 18 in in IN cord-024189-t7mbsr25 48 19 the the DT cord-024189-t7mbsr25 48 20 adventitia adventitia NN cord-024189-t7mbsr25 48 21 . . . cord-024189-t7mbsr25 49 1 DCs DCs NNP cord-024189-t7mbsr25 49 2 are be VBP cord-024189-t7mbsr25 49 3 an an DT cord-024189-t7mbsr25 49 4 indigenous indigenous JJ cord-024189-t7mbsr25 49 5 cell cell NN cord-024189-t7mbsr25 49 6 population population NN cord-024189-t7mbsr25 49 7 in in IN cord-024189-t7mbsr25 49 8 normal normal JJ cord-024189-t7mbsr25 49 9 mediumsized mediumsized JJ cord-024189-t7mbsr25 49 10 and and CC cord-024189-t7mbsr25 49 11 large large JJ cord-024189-t7mbsr25 49 12 vessels vessel NNS cord-024189-t7mbsr25 49 13 . . . cord-024189-t7mbsr25 50 1 In in IN cord-024189-t7mbsr25 50 2 the the DT cord-024189-t7mbsr25 50 3 adventitia adventitia NN cord-024189-t7mbsr25 50 4 , , , cord-024189-t7mbsr25 50 5 they -PRON- PRP cord-024189-t7mbsr25 50 6 are be VBP cord-024189-t7mbsr25 50 7 typically typically RB cord-024189-t7mbsr25 50 8 localized localize VBN cord-024189-t7mbsr25 50 9 at at IN cord-024189-t7mbsr25 50 10 the the DT cord-024189-t7mbsr25 50 11 outside outside NN cord-024189-t7mbsr25 50 12 of of IN cord-024189-t7mbsr25 50 13 the the DT cord-024189-t7mbsr25 50 14 external external JJ cord-024189-t7mbsr25 50 15 elastic elastic JJ cord-024189-t7mbsr25 50 16 lamina lamina NN cord-024189-t7mbsr25 50 17 , , , cord-024189-t7mbsr25 50 18 close close JJ cord-024189-t7mbsr25 50 19 to to IN cord-024189-t7mbsr25 50 20 the the DT cord-024189-t7mbsr25 50 21 adventitia adventitia NN cord-024189-t7mbsr25 50 22 - - HYPH cord-024189-t7mbsr25 50 23 media medium NNS cord-024189-t7mbsr25 50 24 junction junction NN cord-024189-t7mbsr25 50 25 . . . cord-024189-t7mbsr25 51 1 Evidence evidence NN cord-024189-t7mbsr25 51 2 suggests suggest VBZ cord-024189-t7mbsr25 51 3 that that IN cord-024189-t7mbsr25 51 4 these these DT cord-024189-t7mbsr25 51 5 vascular vascular JJ cord-024189-t7mbsr25 51 6 DCs dc NNS cord-024189-t7mbsr25 51 7 utilize utilize VBP cord-024189-t7mbsr25 51 8 Toll Toll NNP cord-024189-t7mbsr25 51 9 - - HYPH cord-024189-t7mbsr25 51 10 like like JJ cord-024189-t7mbsr25 51 11 receptors receptor NNS cord-024189-t7mbsr25 51 12 ( ( -LRB- cord-024189-t7mbsr25 51 13 TLRs TLRs NNP cord-024189-t7mbsr25 51 14 ) ) -RRB- cord-024189-t7mbsr25 51 15 to to TO cord-024189-t7mbsr25 51 16 scan scan VB cord-024189-t7mbsr25 51 17 their -PRON- PRP$ cord-024189-t7mbsr25 51 18 environment environment NN cord-024189-t7mbsr25 51 19 for for IN cord-024189-t7mbsr25 51 20 signs sign NNS cord-024189-t7mbsr25 51 21 of of IN cord-024189-t7mbsr25 51 22 infection infection NN cord-024189-t7mbsr25 51 23 , , , cord-024189-t7mbsr25 51 24 specifi specifi VBN cord-024189-t7mbsr25 51 25 cally cally RB cord-024189-t7mbsr25 51 26 for for IN cord-024189-t7mbsr25 51 27 pathogen pathogen NN cord-024189-t7mbsr25 51 28 - - HYPH cord-024189-t7mbsr25 51 29 related relate VBN cord-024189-t7mbsr25 51 30 molecules molecule NNS cord-024189-t7mbsr25 51 31 . . . cord-024189-t7mbsr25 52 1 In in IN cord-024189-t7mbsr25 52 2 GCA GCA NNP cord-024189-t7mbsr25 52 3 and and CC cord-024189-t7mbsr25 52 4 PMR PMR NNP cord-024189-t7mbsr25 52 5 , , , cord-024189-t7mbsr25 52 6 such such JJ cord-024189-t7mbsr25 52 7 adventitial adventitial JJ cord-024189-t7mbsr25 52 8 DCs dc NNS cord-024189-t7mbsr25 52 9 are be VBP cord-024189-t7mbsr25 52 10 strongly strongly RB cord-024189-t7mbsr25 52 11 activated activate VBN cord-024189-t7mbsr25 52 12 , , , cord-024189-t7mbsr25 52 13 produce produce VBP cord-024189-t7mbsr25 52 14 chemokines chemokine NNS cord-024189-t7mbsr25 52 15 , , , cord-024189-t7mbsr25 52 16 and and CC cord-024189-t7mbsr25 52 17 express express VBP cord-024189-t7mbsr25 52 18 T t NN cord-024189-t7mbsr25 52 19 - - HYPH cord-024189-t7mbsr25 52 20 cell cell NN cord-024189-t7mbsr25 52 21 stimulatory stimulatory JJ cord-024189-t7mbsr25 52 22 ligands ligand NNS cord-024189-t7mbsr25 52 23 . . . cord-024189-t7mbsr25 53 1 This this DT cord-024189-t7mbsr25 53 2 model model NN cord-024189-t7mbsr25 53 3 is be VBZ cord-024189-t7mbsr25 53 4 supported support VBN cord-024189-t7mbsr25 53 5 by by IN cord-024189-t7mbsr25 53 6 experiments experiment NNS cord-024189-t7mbsr25 53 7 in in IN cord-024189-t7mbsr25 53 8 human human JJ cord-024189-t7mbsr25 53 9 artery artery NN cord-024189-t7mbsr25 53 10 mouse mouse NN cord-024189-t7mbsr25 53 11 chimeras chimera NNS cord-024189-t7mbsr25 53 12 . . . cord-024189-t7mbsr25 54 1 In in IN cord-024189-t7mbsr25 54 2 these these DT cord-024189-t7mbsr25 54 3 experiments experiment NNS cord-024189-t7mbsr25 54 4 , , , cord-024189-t7mbsr25 54 5 human human JJ cord-024189-t7mbsr25 54 6 temporal temporal JJ cord-024189-t7mbsr25 54 7 arteries artery NNS cord-024189-t7mbsr25 54 8 from from IN cord-024189-t7mbsr25 54 9 GCA GCA NNP cord-024189-t7mbsr25 54 10 patients patient NNS cord-024189-t7mbsr25 54 11 are be VBP cord-024189-t7mbsr25 54 12 implanted implant VBN cord-024189-t7mbsr25 54 13 into into IN cord-024189-t7mbsr25 54 14 severe severe JJ cord-024189-t7mbsr25 54 15 combined combine VBN cord-024189-t7mbsr25 54 16 immunodefi immunodefi NNP cord-024189-t7mbsr25 54 17 ciency ciency NNP cord-024189-t7mbsr25 54 18 mice mouse NNS cord-024189-t7mbsr25 54 19 . . . cord-024189-t7mbsr25 55 1 Depletion depletion NN cord-024189-t7mbsr25 55 2 of of IN cord-024189-t7mbsr25 55 3 either either DT cord-024189-t7mbsr25 55 4 T T NNP cord-024189-t7mbsr25 55 5 cells cell NNS cord-024189-t7mbsr25 55 6 or or CC cord-024189-t7mbsr25 55 7 DCs dc NNS cord-024189-t7mbsr25 55 8 from from IN cord-024189-t7mbsr25 55 9 the the DT cord-024189-t7mbsr25 55 10 implanted implant VBN cord-024189-t7mbsr25 55 11 vascular vascular JJ cord-024189-t7mbsr25 55 12 lesions lesion NNS cord-024189-t7mbsr25 55 13 terminates terminate VBZ cord-024189-t7mbsr25 55 14 the the DT cord-024189-t7mbsr25 55 15 infl infl NNP cord-024189-t7mbsr25 55 16 ammatory ammatory NNP cord-024189-t7mbsr25 55 17 response response NN cord-024189-t7mbsr25 55 18 , , , cord-024189-t7mbsr25 55 19 with with IN cord-024189-t7mbsr25 55 20 subsequent subsequent JJ cord-024189-t7mbsr25 55 21 clearing clearing NN cord-024189-t7mbsr25 55 22 of of IN cord-024189-t7mbsr25 55 23 the the DT cord-024189-t7mbsr25 55 24 infl infl NNP cord-024189-t7mbsr25 55 25 ammatory ammatory NNP cord-024189-t7mbsr25 55 26 infi infi NNP cord-024189-t7mbsr25 55 27 ltrate ltrate NNP cord-024189-t7mbsr25 55 28 . . . cord-024189-t7mbsr25 56 1 In in IN cord-024189-t7mbsr25 56 2 contrast contrast NN cord-024189-t7mbsr25 56 3 , , , cord-024189-t7mbsr25 56 4 administration administration NN cord-024189-t7mbsr25 56 5 of of IN cord-024189-t7mbsr25 56 6 TLR TLR NNP cord-024189-t7mbsr25 56 7 ligands ligand NNS cord-024189-t7mbsr25 56 8 to to IN cord-024189-t7mbsr25 56 9 chimeras chimera NNS cord-024189-t7mbsr25 56 10 implanted implant VBN cord-024189-t7mbsr25 56 11 with with IN cord-024189-t7mbsr25 56 12 normal normal JJ cord-024189-t7mbsr25 56 13 temporal temporal JJ cord-024189-t7mbsr25 56 14 arteries artery NNS cord-024189-t7mbsr25 56 15 followed follow VBN cord-024189-t7mbsr25 56 16 by by IN cord-024189-t7mbsr25 56 17 the the DT cord-024189-t7mbsr25 56 18 adoptive adoptive JJ cord-024189-t7mbsr25 56 19 transfer transfer NN cord-024189-t7mbsr25 56 20 of of IN cord-024189-t7mbsr25 56 21 T T NNP cord-024189-t7mbsr25 56 22 cells cell NNS cord-024189-t7mbsr25 56 23 is be VBZ cord-024189-t7mbsr25 56 24 suffi suffi NNP cord-024189-t7mbsr25 56 25 cient cient NNP cord-024189-t7mbsr25 56 26 to to TO cord-024189-t7mbsr25 56 27 induce induce VB cord-024189-t7mbsr25 56 28 the the DT cord-024189-t7mbsr25 56 29 initial initial JJ cord-024189-t7mbsr25 56 30 steps step NNS cord-024189-t7mbsr25 56 31 of of IN cord-024189-t7mbsr25 56 32 vasculitis vasculitis NN cord-024189-t7mbsr25 56 33 ( ( -LRB- cord-024189-t7mbsr25 56 34 3 3 CD cord-024189-t7mbsr25 56 35 ) ) -RRB- cord-024189-t7mbsr25 56 36 . . . cord-024189-t7mbsr25 57 1 Based base VBN cord-024189-t7mbsr25 57 2 on on IN cord-024189-t7mbsr25 57 3 these these DT cord-024189-t7mbsr25 57 4 studies study NNS cord-024189-t7mbsr25 57 5 , , , cord-024189-t7mbsr25 57 6 it -PRON- PRP cord-024189-t7mbsr25 57 7 has have VBZ cord-024189-t7mbsr25 57 8 been be VBN cord-024189-t7mbsr25 57 9 proposed propose VBN cord-024189-t7mbsr25 57 10 that that IN cord-024189-t7mbsr25 57 11 the the DT cord-024189-t7mbsr25 57 12 vessel vessel NN cord-024189-t7mbsr25 57 13 wall wall NN cord-024189-t7mbsr25 57 14 , , , cord-024189-t7mbsr25 57 15 in in IN cord-024189-t7mbsr25 57 16 its -PRON- PRP$ cord-024189-t7mbsr25 57 17 physiologic physiologic JJ cord-024189-t7mbsr25 57 18 state state NN cord-024189-t7mbsr25 57 19 , , , cord-024189-t7mbsr25 57 20 is be VBZ cord-024189-t7mbsr25 57 21 an an DT cord-024189-t7mbsr25 57 22 immunoprivileged immunoprivileged JJ cord-024189-t7mbsr25 57 23 site site NN cord-024189-t7mbsr25 57 24 . . . cord-024189-t7mbsr25 58 1 In in IN cord-024189-t7mbsr25 58 2 GCA GCA NNP cord-024189-t7mbsr25 58 3 , , , cord-024189-t7mbsr25 58 4 activation activation NN cord-024189-t7mbsr25 58 5 of of IN cord-024189-t7mbsr25 58 6 vascular vascular JJ cord-024189-t7mbsr25 58 7 DCs dc NNS cord-024189-t7mbsr25 58 8 by by IN cord-024189-t7mbsr25 58 9 microbial microbial JJ cord-024189-t7mbsr25 58 10 products product NNS cord-024189-t7mbsr25 58 11 can can MD cord-024189-t7mbsr25 58 12 break break VB cord-024189-t7mbsr25 58 13 this this DT cord-024189-t7mbsr25 58 14 immunoprivilege immunoprivilege NN cord-024189-t7mbsr25 58 15 and and CC cord-024189-t7mbsr25 58 16 lead lead VB cord-024189-t7mbsr25 58 17 to to IN cord-024189-t7mbsr25 58 18 the the DT cord-024189-t7mbsr25 58 19 recruitment recruitment NN cord-024189-t7mbsr25 58 20 and and CC cord-024189-t7mbsr25 58 21 stimulation stimulation NN cord-024189-t7mbsr25 58 22 of of IN cord-024189-t7mbsr25 58 23 T t NN cord-024189-t7mbsr25 58 24 cells cell NNS cord-024189-t7mbsr25 58 25 . . . cord-024189-t7mbsr25 59 1 The the DT cord-024189-t7mbsr25 59 2 nature nature NN cord-024189-t7mbsr25 59 3 of of IN cord-024189-t7mbsr25 59 4 the the DT cord-024189-t7mbsr25 59 5 peptide peptide NN cord-024189-t7mbsr25 59 6 antigens antigen NNS cord-024189-t7mbsr25 59 7 recognized recognize VBN cord-024189-t7mbsr25 59 8 by by IN cord-024189-t7mbsr25 59 9 these these DT cord-024189-t7mbsr25 59 10 T t NN cord-024189-t7mbsr25 59 11 cells cell NNS cord-024189-t7mbsr25 59 12 is be VBZ cord-024189-t7mbsr25 59 13 Histomorphology Histomorphology NNP cord-024189-t7mbsr25 59 14 of of IN cord-024189-t7mbsr25 59 15 giant giant JJ cord-024189-t7mbsr25 59 16 cell cell NN cord-024189-t7mbsr25 59 17 arteritis arteritis NN cord-024189-t7mbsr25 59 18 . . . cord-024189-t7mbsr25 60 1 A a DT cord-024189-t7mbsr25 60 2 typical typical JJ cord-024189-t7mbsr25 60 3 temporal temporal JJ cord-024189-t7mbsr25 60 4 artery artery NN cord-024189-t7mbsr25 60 5 biopsy biopsy NN cord-024189-t7mbsr25 60 6 specimen specimen NN cord-024189-t7mbsr25 60 7 is be VBZ cord-024189-t7mbsr25 60 8 shown show VBN cord-024189-t7mbsr25 60 9 . . . cord-024189-t7mbsr25 61 1 Characteristic characteristic JJ cord-024189-t7mbsr25 61 2 changes change NNS cord-024189-t7mbsr25 61 3 include include VBP cord-024189-t7mbsr25 61 4 a a DT cord-024189-t7mbsr25 61 5 panmural panmural JJ cord-024189-t7mbsr25 61 6 mononuclear mononuclear FW cord-024189-t7mbsr25 61 7 infi infi NNP cord-024189-t7mbsr25 61 8 ltrate ltrate NNP cord-024189-t7mbsr25 61 9 , , , cord-024189-t7mbsr25 61 10 destruction destruction NN cord-024189-t7mbsr25 61 11 of of IN cord-024189-t7mbsr25 61 12 the the DT cord-024189-t7mbsr25 61 13 internal internal JJ cord-024189-t7mbsr25 61 14 and and CC cord-024189-t7mbsr25 61 15 external external JJ cord-024189-t7mbsr25 61 16 elastic elastic JJ cord-024189-t7mbsr25 61 17 laminae laminae NN cord-024189-t7mbsr25 61 18 , , , cord-024189-t7mbsr25 61 19 and and CC cord-024189-t7mbsr25 61 20 concentric concentric JJ cord-024189-t7mbsr25 61 21 intimal intimal JJ cord-024189-t7mbsr25 61 22 hyperplasia hyperplasia NN cord-024189-t7mbsr25 61 23 . . . cord-024189-t7mbsr25 62 1 undetermined undetermined JJ cord-024189-t7mbsr25 62 2 , , , cord-024189-t7mbsr25 62 3 but but CC cord-024189-t7mbsr25 62 4 it -PRON- PRP cord-024189-t7mbsr25 62 5 may may MD cord-024189-t7mbsr25 62 6 be be VB cord-024189-t7mbsr25 62 7 that that DT cord-024189-t7mbsr25 62 8 common common JJ cord-024189-t7mbsr25 62 9 self self NN cord-024189-t7mbsr25 62 10 - - HYPH cord-024189-t7mbsr25 62 11 antigens antigen NNS cord-024189-t7mbsr25 62 12 are be VBP cord-024189-t7mbsr25 62 13 suffi suffi NNP cord-024189-t7mbsr25 62 14 ciently ciently RB cord-024189-t7mbsr25 62 15 immunogenic immunogenic JJ cord-024189-t7mbsr25 62 16 when when WRB cord-024189-t7mbsr25 62 17 DCs DCs NNP cord-024189-t7mbsr25 62 18 are be VBP cord-024189-t7mbsr25 62 19 activated activate VBN cord-024189-t7mbsr25 62 20 . . . cord-024189-t7mbsr25 63 1 Macrophage macrophage NN cord-024189-t7mbsr25 63 2 function function NN cord-024189-t7mbsr25 63 3 in in IN cord-024189-t7mbsr25 63 4 GCA GCA NNP cord-024189-t7mbsr25 63 5 is be VBZ cord-024189-t7mbsr25 63 6 known know VBN cord-024189-t7mbsr25 63 7 to to TO cord-024189-t7mbsr25 63 8 be be VB cord-024189-t7mbsr25 63 9 multifaceted multifacete VBN cord-024189-t7mbsr25 63 10 , , , cord-024189-t7mbsr25 63 11 with with IN cord-024189-t7mbsr25 63 12 specifi specifi NNP cord-024189-t7mbsr25 63 13 c c NN cord-024189-t7mbsr25 63 14 commitments commitment NNS cord-024189-t7mbsr25 63 15 of of IN cord-024189-t7mbsr25 63 16 these these DT cord-024189-t7mbsr25 63 17 cells cell NNS cord-024189-t7mbsr25 63 18 linked link VBN cord-024189-t7mbsr25 63 19 closely closely RB cord-024189-t7mbsr25 63 20 to to IN cord-024189-t7mbsr25 63 21 their -PRON- PRP$ cord-024189-t7mbsr25 63 22 topographical topographical JJ cord-024189-t7mbsr25 63 23 arrangements arrangement NNS cord-024189-t7mbsr25 63 24 within within IN cord-024189-t7mbsr25 63 25 the the DT cord-024189-t7mbsr25 63 26 cell cell NN cord-024189-t7mbsr25 63 27 wall wall NN cord-024189-t7mbsr25 63 28 ( ( -LRB- cord-024189-t7mbsr25 63 29 4 4 CD cord-024189-t7mbsr25 63 30 ) ) -RRB- cord-024189-t7mbsr25 63 31 . . . cord-024189-t7mbsr25 64 1 Interferon Interferon NNP cord-024189-t7mbsr25 64 2 ( ( -LRB- cord-024189-t7mbsr25 64 3 IFN IFN NNP cord-024189-t7mbsr25 64 4 ) ) -RRB- cord-024189-t7mbsr25 64 5 gamma gamma NNP cord-024189-t7mbsr25 64 6 , , , cord-024189-t7mbsr25 64 7 a a DT cord-024189-t7mbsr25 64 8 T t NN cord-024189-t7mbsr25 64 9 - - HYPH cord-024189-t7mbsr25 64 10 cell cell NN cord-024189-t7mbsr25 64 11 cytokine cytokine NN cord-024189-t7mbsr25 64 12 , , , cord-024189-t7mbsr25 64 13 regulates regulate VBZ cord-024189-t7mbsr25 64 14 both both DT cord-024189-t7mbsr25 64 15 macrophages macrophage NNS cord-024189-t7mbsr25 64 16 and and CC cord-024189-t7mbsr25 64 17 giant giant JJ cord-024189-t7mbsr25 64 18 cells cell NNS cord-024189-t7mbsr25 64 19 . . . cord-024189-t7mbsr25 65 1 Macrophages macrophage NNS cord-024189-t7mbsr25 65 2 in in IN cord-024189-t7mbsr25 65 3 the the DT cord-024189-t7mbsr25 65 4 adventitia adventitia NN cord-024189-t7mbsr25 65 5 , , , cord-024189-t7mbsr25 65 6 intermingling intermingle VBG cord-024189-t7mbsr25 65 7 with with IN cord-024189-t7mbsr25 65 8 activated activate VBN cord-024189-t7mbsr25 65 9 T t NN cord-024189-t7mbsr25 65 10 cells cell NNS cord-024189-t7mbsr25 65 11 , , , cord-024189-t7mbsr25 65 12 produce produce VBP cord-024189-t7mbsr25 65 13 interleukin interleukin NN cord-024189-t7mbsr25 65 14 ( ( -LRB- cord-024189-t7mbsr25 65 15 IL)-1 IL)-1 '' cord-024189-t7mbsr25 65 16 , , , cord-024189-t7mbsr25 65 17 IL-6 IL-6 NNP cord-024189-t7mbsr25 65 18 , , , cord-024189-t7mbsr25 65 19 and and CC cord-024189-t7mbsr25 65 20 transforming transform VBG cord-024189-t7mbsr25 65 21 growth growth NN cord-024189-t7mbsr25 65 22 factor factor NN cord-024189-t7mbsr25 65 23 ( ( -LRB- cord-024189-t7mbsr25 65 24 TGF TGF NNP cord-024189-t7mbsr25 65 25 ) ) -RRB- cord-024189-t7mbsr25 65 26 beta beta NN cord-024189-t7mbsr25 65 27 . . . cord-024189-t7mbsr25 66 1 Macrophages macrophage NNS cord-024189-t7mbsr25 66 2 in in IN cord-024189-t7mbsr25 66 3 the the DT cord-024189-t7mbsr25 66 4 medial medial JJ cord-024189-t7mbsr25 66 5 layer layer NN cord-024189-t7mbsr25 66 6 are be VBP cord-024189-t7mbsr25 66 7 specialized specialize VBN cord-024189-t7mbsr25 66 8 in in IN cord-024189-t7mbsr25 66 9 the the DT cord-024189-t7mbsr25 66 10 production production NN cord-024189-t7mbsr25 66 11 of of IN cord-024189-t7mbsr25 66 12 metalloproteinases metalloproteinase NNS cord-024189-t7mbsr25 66 13 , , , cord-024189-t7mbsr25 66 14 and and CC cord-024189-t7mbsr25 66 15 also also RB cord-024189-t7mbsr25 66 16 contribute contribute VB cord-024189-t7mbsr25 66 17 to to IN cord-024189-t7mbsr25 66 18 oxidative oxidative JJ cord-024189-t7mbsr25 66 19 damage damage NN cord-024189-t7mbsr25 66 20 . . . cord-024189-t7mbsr25 67 1 End end NN cord-024189-t7mbsr25 67 2 products product NNS cord-024189-t7mbsr25 67 3 of of IN cord-024189-t7mbsr25 67 4 lipid lipid NN cord-024189-t7mbsr25 67 5 peroxidation peroxidation NN cord-024189-t7mbsr25 67 6 , , , cord-024189-t7mbsr25 67 7 a a DT cord-024189-t7mbsr25 67 8 cell cell NN cord-024189-t7mbsr25 67 9 injury injury NN cord-024189-t7mbsr25 67 10 mechanism mechanism NN cord-024189-t7mbsr25 67 11 driven drive VBN cord-024189-t7mbsr25 67 12 by by IN cord-024189-t7mbsr25 67 13 oxygen oxygen NN cord-024189-t7mbsr25 67 14 radicals radical NNS cord-024189-t7mbsr25 67 15 , , , cord-024189-t7mbsr25 67 16 are be VBP cord-024189-t7mbsr25 67 17 typically typically RB cord-024189-t7mbsr25 67 18 found find VBN cord-024189-t7mbsr25 67 19 on on IN cord-024189-t7mbsr25 67 20 medial medial JJ cord-024189-t7mbsr25 67 21 smooth smooth JJ cord-024189-t7mbsr25 67 22 muscle muscle NN cord-024189-t7mbsr25 67 23 cells cell NNS cord-024189-t7mbsr25 67 24 ( ( -LRB- cord-024189-t7mbsr25 67 25 5 5 CD cord-024189-t7mbsr25 67 26 ) ) -RRB- cord-024189-t7mbsr25 67 27 . . . cord-024189-t7mbsr25 68 1 Macrophages macrophage NNS cord-024189-t7mbsr25 68 2 recruited recruit VBN cord-024189-t7mbsr25 68 3 to to IN cord-024189-t7mbsr25 68 4 the the DT cord-024189-t7mbsr25 68 5 intimal intimal JJ cord-024189-t7mbsr25 68 6 layer layer NN cord-024189-t7mbsr25 68 7 are be VBP cord-024189-t7mbsr25 68 8 committed commit VBN cord-024189-t7mbsr25 68 9 to to IN cord-024189-t7mbsr25 68 10 the the DT cord-024189-t7mbsr25 68 11 production production NN cord-024189-t7mbsr25 68 12 of of IN cord-024189-t7mbsr25 68 13 nitric nitric NN cord-024189-t7mbsr25 68 14 oxide oxide NN cord-024189-t7mbsr25 68 15 synthase-2 synthase-2 ADD cord-024189-t7mbsr25 68 16 . . . cord-024189-t7mbsr25 69 1 Nitric nitric NN cord-024189-t7mbsr25 69 2 oxide oxide NN cord-024189-t7mbsr25 69 3 is be VBZ cord-024189-t7mbsr25 69 4 suspected suspect VBN cord-024189-t7mbsr25 69 5 to to TO cord-024189-t7mbsr25 69 6 be be VB cord-024189-t7mbsr25 69 7 involved involve VBN cord-024189-t7mbsr25 69 8 in in IN cord-024189-t7mbsr25 69 9 tissue tissue NN cord-024189-t7mbsr25 69 10 injury injury NN cord-024189-t7mbsr25 69 11 , , , cord-024189-t7mbsr25 69 12 cellular cellular JJ cord-024189-t7mbsr25 69 13 activation activation NN cord-024189-t7mbsr25 69 14 , , , cord-024189-t7mbsr25 69 15 and and CC cord-024189-t7mbsr25 69 16 vascular vascular JJ cord-024189-t7mbsr25 69 17 remodeling remodeling NN cord-024189-t7mbsr25 69 18 . . . cord-024189-t7mbsr25 70 1 Multinucleated multinucleated JJ cord-024189-t7mbsr25 70 2 giant giant JJ cord-024189-t7mbsr25 70 3 cells cell NNS cord-024189-t7mbsr25 70 4 , , , cord-024189-t7mbsr25 70 5 once once RB cord-024189-t7mbsr25 70 6 assumed assume VBN cord-024189-t7mbsr25 70 7 to to TO cord-024189-t7mbsr25 70 8 function function VB cord-024189-t7mbsr25 70 9 in in IN cord-024189-t7mbsr25 70 10 the the DT cord-024189-t7mbsr25 70 11 removal removal NN cord-024189-t7mbsr25 70 12 of of IN cord-024189-t7mbsr25 70 13 indigestible indigestible JJ cord-024189-t7mbsr25 70 14 debris debris NN cord-024189-t7mbsr25 70 15 , , , cord-024189-t7mbsr25 70 16 are be VBP cord-024189-t7mbsr25 70 17 actually actually RB cord-024189-t7mbsr25 70 18 active active JJ cord-024189-t7mbsr25 70 19 secretory secretory JJ cord-024189-t7mbsr25 70 20 cells cell NNS cord-024189-t7mbsr25 70 21 , , , cord-024189-t7mbsr25 70 22 producing produce VBG cord-024189-t7mbsr25 70 23 molecular molecular JJ cord-024189-t7mbsr25 70 24 mediators mediator NNS cord-024189-t7mbsr25 70 25 relevant relevant JJ cord-024189-t7mbsr25 70 26 in in IN cord-024189-t7mbsr25 70 27 structurally structurally RB cord-024189-t7mbsr25 70 28 changing change VBG cord-024189-t7mbsr25 70 29 the the DT cord-024189-t7mbsr25 70 30 arterial arterial JJ cord-024189-t7mbsr25 70 31 wall wall NN cord-024189-t7mbsr25 70 32 . . . cord-024189-t7mbsr25 71 1 The the DT cord-024189-t7mbsr25 71 2 presence presence NN cord-024189-t7mbsr25 71 3 of of IN cord-024189-t7mbsr25 71 4 giant giant JJ cord-024189-t7mbsr25 71 5 cells cell NNS cord-024189-t7mbsr25 71 6 in in IN cord-024189-t7mbsr25 71 7 GCA GCA NNP cord-024189-t7mbsr25 71 8 corresponds correspond VBZ cord-024189-t7mbsr25 71 9 with with IN cord-024189-t7mbsr25 71 10 the the DT cord-024189-t7mbsr25 71 11 presence presence NN cord-024189-t7mbsr25 71 12 of of IN cord-024189-t7mbsr25 71 13 high high JJ cord-024189-t7mbsr25 71 14 adventitial adventitial JJ cord-024189-t7mbsr25 71 15 levels level NNS cord-024189-t7mbsr25 71 16 of of IN cord-024189-t7mbsr25 71 17 IFN IFN NNP cord-024189-t7mbsr25 71 18 - - HYPH cord-024189-t7mbsr25 71 19 gamma gamma NNP cord-024189-t7mbsr25 71 20 ( ( -LRB- cord-024189-t7mbsr25 71 21 6 6 CD cord-024189-t7mbsr25 71 22 ) ) -RRB- cord-024189-t7mbsr25 71 23 . . . cord-024189-t7mbsr25 72 1 The the DT cord-024189-t7mbsr25 72 2 assumption assumption NN cord-024189-t7mbsr25 72 3 that that IN cord-024189-t7mbsr25 72 4 all all DT cord-024189-t7mbsr25 72 5 pathogenic pathogenic JJ cord-024189-t7mbsr25 72 6 mechanisms mechanism NNS cord-024189-t7mbsr25 72 7 in in IN cord-024189-t7mbsr25 72 8 infl infl NNP cord-024189-t7mbsr25 72 9 amed amed NNP cord-024189-t7mbsr25 72 10 arteries artery NNS cord-024189-t7mbsr25 72 11 are be VBP cord-024189-t7mbsr25 72 12 mediated mediate VBN cord-024189-t7mbsr25 72 13 by by IN cord-024189-t7mbsr25 72 14 tissue tissue NN cord-024189-t7mbsr25 72 15 - - HYPH cord-024189-t7mbsr25 72 16 infi infi NNP cord-024189-t7mbsr25 72 17 ltrating ltrating NN cord-024189-t7mbsr25 72 18 immune immune JJ cord-024189-t7mbsr25 72 19 cells cell NNS cord-024189-t7mbsr25 72 20 is be VBZ cord-024189-t7mbsr25 72 21 simplistic simplistic JJ cord-024189-t7mbsr25 72 22 . . . cord-024189-t7mbsr25 73 1 T T NNP cord-024189-t7mbsr25 73 2 cells cell NNS cord-024189-t7mbsr25 73 3 and and CC cord-024189-t7mbsr25 73 4 macrophages macrophage NNS cord-024189-t7mbsr25 73 5 in in IN cord-024189-t7mbsr25 73 6 the the DT cord-024189-t7mbsr25 73 7 arterial arterial JJ cord-024189-t7mbsr25 73 8 wall wall NN cord-024189-t7mbsr25 73 9 do do VBP cord-024189-t7mbsr25 73 10 not not RB cord-024189-t7mbsr25 73 11 live live VB cord-024189-t7mbsr25 73 12 and and CC cord-024189-t7mbsr25 73 13 function function VB cord-024189-t7mbsr25 73 14 in in IN cord-024189-t7mbsr25 73 15 isolation isolation NN cord-024189-t7mbsr25 73 16 , , , cord-024189-t7mbsr25 73 17 but but CC cord-024189-t7mbsr25 73 18 rather rather RB cord-024189-t7mbsr25 73 19 closely closely RB cord-024189-t7mbsr25 73 20 interact interact VB cord-024189-t7mbsr25 73 21 with with IN cord-024189-t7mbsr25 73 22 stromal stromal JJ cord-024189-t7mbsr25 73 23 components component NNS cord-024189-t7mbsr25 73 24 of of IN cord-024189-t7mbsr25 73 25 the the DT cord-024189-t7mbsr25 73 26 blood blood NN cord-024189-t7mbsr25 73 27 vessel vessel NN cord-024189-t7mbsr25 73 28 in in IN cord-024189-t7mbsr25 73 29 a a DT cord-024189-t7mbsr25 73 30 bidirectional bidirectional JJ cord-024189-t7mbsr25 73 31 pattern pattern NN cord-024189-t7mbsr25 73 32 ( ( -LRB- cord-024189-t7mbsr25 73 33 7 7 CD cord-024189-t7mbsr25 73 34 ) ) -RRB- cord-024189-t7mbsr25 73 35 . . . cord-024189-t7mbsr25 74 1 The the DT cord-024189-t7mbsr25 74 2 major major JJ cord-024189-t7mbsr25 74 3 vascular vascular JJ cord-024189-t7mbsr25 74 4 abnormality abnormality NN cord-024189-t7mbsr25 74 5 leading lead VBG cord-024189-t7mbsr25 74 6 to to IN cord-024189-t7mbsr25 74 7 clinical clinical JJ cord-024189-t7mbsr25 74 8 disease disease NN cord-024189-t7mbsr25 74 9 is be VBZ cord-024189-t7mbsr25 74 10 a a DT cord-024189-t7mbsr25 74 11 nonthrombotic nonthrombotic JJ cord-024189-t7mbsr25 74 12 luminal luminal JJ cord-024189-t7mbsr25 74 13 occlusion occlusion NN cord-024189-t7mbsr25 74 14 , , , cord-024189-t7mbsr25 74 15 caused cause VBN cord-024189-t7mbsr25 74 16 by by IN cord-024189-t7mbsr25 74 17 rapid rapid JJ cord-024189-t7mbsr25 74 18 and and CC cord-024189-t7mbsr25 74 19 concentric concentric JJ cord-024189-t7mbsr25 74 20 growth growth NN cord-024189-t7mbsr25 74 21 of of IN cord-024189-t7mbsr25 74 22 the the DT cord-024189-t7mbsr25 74 23 intima intima NN cord-024189-t7mbsr25 74 24 . . . cord-024189-t7mbsr25 75 1 These these DT cord-024189-t7mbsr25 75 2 structural structural JJ cord-024189-t7mbsr25 75 3 alterations alteration NNS cord-024189-t7mbsr25 75 4 result result VBP cord-024189-t7mbsr25 75 5 from from IN cord-024189-t7mbsr25 75 6 the the DT cord-024189-t7mbsr25 75 7 response response NN cord-024189-t7mbsr25 75 8 to to IN cord-024189-t7mbsr25 75 9 injury injury NN cord-024189-t7mbsr25 75 10 elicited elicit VBN cord-024189-t7mbsr25 75 11 in in IN cord-024189-t7mbsr25 75 12 arterial arterial JJ cord-024189-t7mbsr25 75 13 cells cell NNS cord-024189-t7mbsr25 75 14 ( ( -LRB- cord-024189-t7mbsr25 75 15 Figure figure NN cord-024189-t7mbsr25 75 16 21A 21a NN cord-024189-t7mbsr25 75 17 -2 -2 CD cord-024189-t7mbsr25 75 18 ) ) -RRB- cord-024189-t7mbsr25 75 19 . . . cord-024189-t7mbsr25 76 1 Intimal intimal JJ cord-024189-t7mbsr25 76 2 hyperplasia hyperplasia NN cord-024189-t7mbsr25 76 3 is be VBZ cord-024189-t7mbsr25 76 4 generated generate VBN cord-024189-t7mbsr25 76 5 by by IN cord-024189-t7mbsr25 76 6 the the DT cord-024189-t7mbsr25 76 7 mobilization mobilization NN cord-024189-t7mbsr25 76 8 of of IN cord-024189-t7mbsr25 76 9 smooth smooth JJ cord-024189-t7mbsr25 76 10 muscle muscle NN cord-024189-t7mbsr25 76 11 cells cell NNS cord-024189-t7mbsr25 76 12 , , , cord-024189-t7mbsr25 76 13 their -PRON- PRP$ cord-024189-t7mbsr25 76 14 directed direct VBN cord-024189-t7mbsr25 76 15 migration migration NN cord-024189-t7mbsr25 76 16 towards towards IN cord-024189-t7mbsr25 76 17 the the DT cord-024189-t7mbsr25 76 18 lumen lumen NN cord-024189-t7mbsr25 76 19 , , , cord-024189-t7mbsr25 76 20 and and CC cord-024189-t7mbsr25 76 21 their -PRON- PRP$ cord-024189-t7mbsr25 76 22 proliferation proliferation NN cord-024189-t7mbsr25 76 23 and and CC cord-024189-t7mbsr25 76 24 matrix matrix NN cord-024189-t7mbsr25 76 25 deposition deposition NN cord-024189-t7mbsr25 76 26 . . . cord-024189-t7mbsr25 77 1 This this DT cord-024189-t7mbsr25 77 2 process process NN cord-024189-t7mbsr25 77 3 is be VBZ cord-024189-t7mbsr25 77 4 under under IN cord-024189-t7mbsr25 77 5 the the DT cord-024189-t7mbsr25 77 6 control control NN cord-024189-t7mbsr25 77 7 of of IN cord-024189-t7mbsr25 77 8 growth growth NN cord-024189-t7mbsr25 77 9 factors factor NNS cord-024189-t7mbsr25 77 10 . . . cord-024189-t7mbsr25 78 1 Platelet platelet NN cord-024189-t7mbsr25 78 2 - - HYPH cord-024189-t7mbsr25 78 3 derived derive VBN cord-024189-t7mbsr25 78 4 growth growth NN cord-024189-t7mbsr25 78 5 factor factor NN cord-024189-t7mbsr25 78 6 ( ( -LRB- cord-024189-t7mbsr25 78 7 PDGF PDGF NNP cord-024189-t7mbsr25 78 8 ) ) -RRB- cord-024189-t7mbsr25 78 9 , , , cord-024189-t7mbsr25 78 10 a a DT cord-024189-t7mbsr25 78 11 factor factor NN cord-024189-t7mbsr25 78 12 with with IN cord-024189-t7mbsr25 78 13 the the DT cord-024189-t7mbsr25 78 14 capability capability NN cord-024189-t7mbsr25 78 15 of of IN cord-024189-t7mbsr25 78 16 supporting support VBG cord-024189-t7mbsr25 78 17 the the DT cord-024189-t7mbsr25 78 18 outgrowth outgrowth NN cord-024189-t7mbsr25 78 19 of of IN cord-024189-t7mbsr25 78 20 the the DT cord-024189-t7mbsr25 78 21 hyperplastic hyperplastic JJ cord-024189-t7mbsr25 78 22 intima intima NN cord-024189-t7mbsr25 78 23 , , , cord-024189-t7mbsr25 78 24 is be VBZ cord-024189-t7mbsr25 78 25 present present JJ cord-024189-t7mbsr25 78 26 in in IN cord-024189-t7mbsr25 78 27 infl infl NNP cord-024189-t7mbsr25 78 28 amed amed NNP cord-024189-t7mbsr25 78 29 arteries artery NNS cord-024189-t7mbsr25 78 30 . . . cord-024189-t7mbsr25 79 1 PDGF PDGF NNP cord-024189-t7mbsr25 79 2 derives derive VBZ cord-024189-t7mbsr25 79 3 from from IN cord-024189-t7mbsr25 79 4 macrophages macrophage NNS cord-024189-t7mbsr25 79 5 and and CC cord-024189-t7mbsr25 79 6 multinucleated multinucleate VBN cord-024189-t7mbsr25 79 7 giant giant JJ cord-024189-t7mbsr25 79 8 cells cell NNS cord-024189-t7mbsr25 79 9 . . . cord-024189-t7mbsr25 80 1 Patients patient NNS cord-024189-t7mbsr25 80 2 with with IN cord-024189-t7mbsr25 80 3 low low JJ cord-024189-t7mbsr25 80 4 PDGF PDGF NNP cord-024189-t7mbsr25 80 5 production production NN cord-024189-t7mbsr25 80 6 have have VBP cord-024189-t7mbsr25 80 7 no no DT cord-024189-t7mbsr25 80 8 or or CC cord-024189-t7mbsr25 80 9 minimal minimal JJ cord-024189-t7mbsr25 80 10 lumen lumen JJ cord-024189-t7mbsr25 80 11 - - HYPH cord-024189-t7mbsr25 80 12 occlusive occlusive JJ cord-024189-t7mbsr25 80 13 intimal intimal JJ cord-024189-t7mbsr25 80 14 proliferation proliferation NN cord-024189-t7mbsr25 80 15 . . . cord-024189-t7mbsr25 81 1 In in IN cord-024189-t7mbsr25 81 2 contrast contrast NN cord-024189-t7mbsr25 81 3 , , , cord-024189-t7mbsr25 81 4 those those DT cord-024189-t7mbsr25 81 5 with with IN cord-024189-t7mbsr25 81 6 excessive excessive JJ cord-024189-t7mbsr25 81 7 PDGF PDGF NNP cord-024189-t7mbsr25 81 8 production production NN cord-024189-t7mbsr25 81 9 are be VBP cord-024189-t7mbsr25 81 10 at at IN cord-024189-t7mbsr25 81 11 a a DT cord-024189-t7mbsr25 81 12 risk risk NN cord-024189-t7mbsr25 81 13 for for IN cord-024189-t7mbsr25 81 14 ischemic ischemic JJ cord-024189-t7mbsr25 81 15 complications complication NNS cord-024189-t7mbsr25 81 16 ( ( -LRB- cord-024189-t7mbsr25 81 17 8) 8) NNP cord-024189-t7mbsr25 81 18 . . . cord-024189-t7mbsr25 82 1 A a DT cord-024189-t7mbsr25 82 2 second second JJ cord-024189-t7mbsr25 82 3 pathway pathway NN cord-024189-t7mbsr25 82 4 of of IN cord-024189-t7mbsr25 82 5 the the DT cord-024189-t7mbsr25 82 6 arterial arterial JJ cord-024189-t7mbsr25 82 7 injury injury NN cord-024189-t7mbsr25 82 8 - - HYPH cord-024189-t7mbsr25 82 9 response response NN cord-024189-t7mbsr25 82 10 program program NN cord-024189-t7mbsr25 82 11 relates relate VBZ cord-024189-t7mbsr25 82 12 to to IN cord-024189-t7mbsr25 82 13 the the DT cord-024189-t7mbsr25 82 14 formation formation NN cord-024189-t7mbsr25 82 15 of of IN cord-024189-t7mbsr25 82 16 new new JJ cord-024189-t7mbsr25 82 17 capillaries capillary NNS cord-024189-t7mbsr25 82 18 . . . cord-024189-t7mbsr25 83 1 The the DT cord-024189-t7mbsr25 83 2 media medium NNS cord-024189-t7mbsr25 83 3 and and CC cord-024189-t7mbsr25 83 4 intima intima NN cord-024189-t7mbsr25 83 5 of of IN cord-024189-t7mbsr25 83 6 normal normal JJ cord-024189-t7mbsr25 83 7 arteries artery NNS cord-024189-t7mbsr25 83 8 are be VBP cord-024189-t7mbsr25 83 9 avascular avascular JJ cord-024189-t7mbsr25 83 10 , , , cord-024189-t7mbsr25 83 11 but but CC cord-024189-t7mbsr25 83 12 intense intense JJ cord-024189-t7mbsr25 83 13 neoangiogenesis neoangiogenesis NNP cord-024189-t7mbsr25 83 14 is be VBZ cord-024189-t7mbsr25 83 15 induced induce VBN cord-024189-t7mbsr25 83 16 in in IN cord-024189-t7mbsr25 83 17 GCA GCA NNP cord-024189-t7mbsr25 83 18 ( ( -LRB- cord-024189-t7mbsr25 83 19 9 9 CD cord-024189-t7mbsr25 83 20 ) ) -RRB- cord-024189-t7mbsr25 83 21 . . . cord-024189-t7mbsr25 84 1 Vascular vascular JJ cord-024189-t7mbsr25 84 2 endothelial endothelial JJ cord-024189-t7mbsr25 84 3 growth growth NN cord-024189-t7mbsr25 84 4 factor factor NN cord-024189-t7mbsr25 84 5 ( ( -LRB- cord-024189-t7mbsr25 84 6 VEGF VEGF NNP cord-024189-t7mbsr25 84 7 ) ) -RRB- cord-024189-t7mbsr25 84 8 is be VBZ cord-024189-t7mbsr25 84 9 critical critical JJ cord-024189-t7mbsr25 84 10 in in IN cord-024189-t7mbsr25 84 11 driving drive VBG cord-024189-t7mbsr25 84 12 the the DT cord-024189-t7mbsr25 84 13 generation generation NN cord-024189-t7mbsr25 84 14 of of IN cord-024189-t7mbsr25 84 15 neovessels neovessel NNS cord-024189-t7mbsr25 84 16 in in IN cord-024189-t7mbsr25 84 17 the the DT cord-024189-t7mbsr25 84 18 media medium NNS cord-024189-t7mbsr25 84 19 and and CC cord-024189-t7mbsr25 84 20 intima intima NN cord-024189-t7mbsr25 84 21 . . . cord-024189-t7mbsr25 85 1 VEGF VEGF NNP cord-024189-t7mbsr25 85 2 , , , cord-024189-t7mbsr25 85 3 like like IN cord-024189-t7mbsr25 85 4 PDGF PDGF NNP cord-024189-t7mbsr25 85 5 , , , cord-024189-t7mbsr25 85 6 originates originate VBZ cord-024189-t7mbsr25 85 7 from from IN cord-024189-t7mbsr25 85 8 macrophages macrophage NNS cord-024189-t7mbsr25 85 9 and and CC cord-024189-t7mbsr25 85 10 multinucleated multinucleate VBN cord-024189-t7mbsr25 85 11 giant giant JJ cord-024189-t7mbsr25 85 12 cells cell NNS cord-024189-t7mbsr25 85 13 . . . cord-024189-t7mbsr25 86 1 The the DT cord-024189-t7mbsr25 86 2 arterial arterial JJ cord-024189-t7mbsr25 86 3 response response NN cord-024189-t7mbsr25 86 4 pattern pattern NN cord-024189-t7mbsr25 86 5 initiated initiate VBN cord-024189-t7mbsr25 86 6 by by IN cord-024189-t7mbsr25 86 7 the the DT cord-024189-t7mbsr25 86 8 production production NN cord-024189-t7mbsr25 86 9 of of IN cord-024189-t7mbsr25 86 10 PDGF PDGF NNP cord-024189-t7mbsr25 86 11 and and CC cord-024189-t7mbsr25 86 12 VEGF VEGF NNP cord-024189-t7mbsr25 86 13 leads lead VBZ cord-024189-t7mbsr25 86 14 to to IN cord-024189-t7mbsr25 86 15 profound profound JJ cord-024189-t7mbsr25 86 16 structural structural JJ cord-024189-t7mbsr25 86 17 arterial arterial JJ cord-024189-t7mbsr25 86 18 abnormalities abnormality NNS cord-024189-t7mbsr25 86 19 with with IN cord-024189-t7mbsr25 86 20 subsequent subsequent JJ cord-024189-t7mbsr25 86 21 stenosis stenosis NN cord-024189-t7mbsr25 86 22 and and CC cord-024189-t7mbsr25 86 23 tissue tissue NN cord-024189-t7mbsr25 86 24 ischemia ischemia NN cord-024189-t7mbsr25 86 25 , , , cord-024189-t7mbsr25 86 26 emphasizing emphasize VBG cord-024189-t7mbsr25 86 27 that that IN cord-024189-t7mbsr25 86 28 the the DT cord-024189-t7mbsr25 86 29 immune immune JJ cord-024189-t7mbsr25 86 30 system system NN cord-024189-t7mbsr25 86 31 coerces coerce VBZ cord-024189-t7mbsr25 86 32 the the DT cord-024189-t7mbsr25 86 33 artery artery NN cord-024189-t7mbsr25 86 34 toward toward IN cord-024189-t7mbsr25 86 35 a a DT cord-024189-t7mbsr25 86 36 counterproductive counterproductive JJ cord-024189-t7mbsr25 86 37 pattern pattern NN cord-024189-t7mbsr25 86 38 of of IN cord-024189-t7mbsr25 86 39 reaction reaction NN cord-024189-t7mbsr25 86 40 . . . cord-024189-t7mbsr25 87 1 However however RB cord-024189-t7mbsr25 87 2 , , , cord-024189-t7mbsr25 87 3 the the DT cord-024189-t7mbsr25 87 4 infl infl NN cord-024189-t7mbsr25 87 5 ammation ammation NNP cord-024189-t7mbsr25 87 6 also also RB cord-024189-t7mbsr25 87 7 leads lead VBZ cord-024189-t7mbsr25 87 8 to to IN cord-024189-t7mbsr25 87 9 the the DT cord-024189-t7mbsr25 87 10 induction induction NN cord-024189-t7mbsr25 87 11 of of IN cord-024189-t7mbsr25 87 12 protective protective JJ cord-024189-t7mbsr25 87 13 response response NN cord-024189-t7mbsr25 87 14 patterns pattern NNS cord-024189-t7mbsr25 87 15 that that WDT cord-024189-t7mbsr25 87 16 are be VBP cord-024189-t7mbsr25 87 17 aimed aim VBN cord-024189-t7mbsr25 87 18 at at IN cord-024189-t7mbsr25 87 19 healing healing NN cord-024189-t7mbsr25 87 20 and and CC cord-024189-t7mbsr25 87 21 tissue tissue NN cord-024189-t7mbsr25 87 22 repair repair NN cord-024189-t7mbsr25 87 23 . . . cord-024189-t7mbsr25 88 1 An an DT cord-024189-t7mbsr25 88 2 example example NN cord-024189-t7mbsr25 88 3 is be VBZ cord-024189-t7mbsr25 88 4 the the DT cord-024189-t7mbsr25 88 5 upregulation upregulation NN cord-024189-t7mbsr25 88 6 of of IN cord-024189-t7mbsr25 88 7 the the DT cord-024189-t7mbsr25 88 8 enzyme enzyme NN cord-024189-t7mbsr25 88 9 , , , cord-024189-t7mbsr25 88 10 aldose aldose NNP cord-024189-t7mbsr25 88 11 reductase reductase NN cord-024189-t7mbsr25 88 12 ( ( -LRB- cord-024189-t7mbsr25 88 13 10 10 CD cord-024189-t7mbsr25 88 14 ) ) -RRB- cord-024189-t7mbsr25 88 15 , , , cord-024189-t7mbsr25 88 16 which which WDT cord-024189-t7mbsr25 88 17 metabolizes metabolize VBZ cord-024189-t7mbsr25 88 18 and and CC cord-024189-t7mbsr25 88 19 detoxifi detoxifi NNP cord-024189-t7mbsr25 88 20 es es XX cord-024189-t7mbsr25 88 21 end end NN cord-024189-t7mbsr25 88 22 products product NNS cord-024189-t7mbsr25 88 23 of of IN cord-024189-t7mbsr25 88 24 oxidative oxidative JJ cord-024189-t7mbsr25 88 25 damage damage NN cord-024189-t7mbsr25 88 26 . . . cord-024189-t7mbsr25 89 1 The the DT cord-024189-t7mbsr25 89 2 activation activation NN cord-024189-t7mbsr25 89 3 of of IN cord-024189-t7mbsr25 89 4 vascular vascular JJ cord-024189-t7mbsr25 89 5 DCs dc NNS cord-024189-t7mbsr25 89 6 as as IN cord-024189-t7mbsr25 89 7 an an DT cord-024189-t7mbsr25 89 8 early early JJ cord-024189-t7mbsr25 89 9 step step NN cord-024189-t7mbsr25 89 10 in in IN cord-024189-t7mbsr25 89 11 the the DT cord-024189-t7mbsr25 89 12 pathogenesis pathogenesis NN cord-024189-t7mbsr25 89 13 of of IN cord-024189-t7mbsr25 89 14 GCA GCA NNP cord-024189-t7mbsr25 89 15 has have VBZ cord-024189-t7mbsr25 89 16 two two CD cord-024189-t7mbsr25 89 17 major major JJ cord-024189-t7mbsr25 89 18 implications implication NNS cord-024189-t7mbsr25 89 19 : : : cord-024189-t7mbsr25 89 20 ( ( -LRB- cord-024189-t7mbsr25 89 21 1 1 LS cord-024189-t7mbsr25 89 22 ) ) -RRB- cord-024189-t7mbsr25 90 1 Infl Infl NNP cord-024189-t7mbsr25 90 2 ammation ammation NN cord-024189-t7mbsr25 90 3 and and CC cord-024189-t7mbsr25 90 4 immune immune JJ cord-024189-t7mbsr25 90 5 activation activation NN cord-024189-t7mbsr25 90 6 are be VBP cord-024189-t7mbsr25 90 7 not not RB cord-024189-t7mbsr25 90 8 limited limited JJ cord-024189-t7mbsr25 90 9 to to IN cord-024189-t7mbsr25 90 10 vascular vascular JJ cord-024189-t7mbsr25 90 11 lesions lesion NNS cord-024189-t7mbsr25 90 12 ; ; : cord-024189-t7mbsr25 90 13 and and CC cord-024189-t7mbsr25 90 14 ( ( -LRB- cord-024189-t7mbsr25 90 15 2 2 LS cord-024189-t7mbsr25 90 16 ) ) -RRB- cord-024189-t7mbsr25 90 17 a a DT cord-024189-t7mbsr25 90 18 systemic systemic JJ cord-024189-t7mbsr25 90 19 component component NN cord-024189-t7mbsr25 90 20 of of IN cord-024189-t7mbsr25 90 21 GCA GCA NNP cord-024189-t7mbsr25 90 22 is be VBZ cord-024189-t7mbsr25 90 23 an an DT cord-024189-t7mbsr25 90 24 independent independent JJ cord-024189-t7mbsr25 90 25 dimension dimension NN cord-024189-t7mbsr25 90 26 of of IN cord-024189-t7mbsr25 90 27 the the DT cord-024189-t7mbsr25 90 28 disease disease NN cord-024189-t7mbsr25 90 29 process process NN cord-024189-t7mbsr25 90 30 and and CC cord-024189-t7mbsr25 90 31 not not RB cord-024189-t7mbsr25 90 32 simply simply RB cord-024189-t7mbsr25 90 33 a a DT cord-024189-t7mbsr25 90 34 spillover spillover NN cord-024189-t7mbsr25 90 35 from from IN cord-024189-t7mbsr25 90 36 vessel vessel NN cord-024189-t7mbsr25 90 37 wall wall NN cord-024189-t7mbsr25 90 38 infl infl NNP cord-024189-t7mbsr25 90 39 ammation ammation NNP cord-024189-t7mbsr25 90 40 . . . cord-024189-t7mbsr25 91 1 Further further JJ cord-024189-t7mbsr25 91 2 evidence evidence NN cord-024189-t7mbsr25 91 3 for for IN cord-024189-t7mbsr25 91 4 this this DT cord-024189-t7mbsr25 91 5 systemic systemic JJ cord-024189-t7mbsr25 91 6 component component NN cord-024189-t7mbsr25 91 7 is be VBZ cord-024189-t7mbsr25 91 8 the the DT cord-024189-t7mbsr25 91 9 activation activation NN cord-024189-t7mbsr25 91 10 in in IN cord-024189-t7mbsr25 91 11 GCA GCA NNP cord-024189-t7mbsr25 91 12 patients patient NNS cord-024189-t7mbsr25 91 13 of of IN cord-024189-t7mbsr25 91 14 circulating circulate VBG cord-024189-t7mbsr25 91 15 monocytes monocyte NNS cord-024189-t7mbsr25 91 16 , , , cord-024189-t7mbsr25 91 17 which which WDT cord-024189-t7mbsr25 91 18 produce produce VBP cord-024189-t7mbsr25 91 19 IL-1 IL-1 NNP cord-024189-t7mbsr25 91 20 and and CC cord-024189-t7mbsr25 91 21 IL-6 IL-6 NNP cord-024189-t7mbsr25 91 22 . . . cord-024189-t7mbsr25 92 1 Elevated elevated JJ cord-024189-t7mbsr25 92 2 levels level NNS cord-024189-t7mbsr25 92 3 of of IN cord-024189-t7mbsr25 92 4 IL-6 IL-6 NNP cord-024189-t7mbsr25 92 5 , , , cord-024189-t7mbsr25 92 6 a a DT cord-024189-t7mbsr25 92 7 potent potent JJ cord-024189-t7mbsr25 92 8 inducer inducer NN cord-024189-t7mbsr25 92 9 of of IN cord-024189-t7mbsr25 92 10 acute acute JJ cord-024189-t7mbsr25 92 11 phase phase NN cord-024189-t7mbsr25 92 12 responses response NNS cord-024189-t7mbsr25 92 13 , , , cord-024189-t7mbsr25 92 14 are be VBP cord-024189-t7mbsr25 92 15 characteristic characteristic JJ cord-024189-t7mbsr25 92 16 of of IN cord-024189-t7mbsr25 92 17 GCA GCA NNP cord-024189-t7mbsr25 92 18 . . . cord-024189-t7mbsr25 93 1 In in IN cord-024189-t7mbsr25 93 2 this this DT cord-024189-t7mbsr25 93 3 model model NN cord-024189-t7mbsr25 93 4 , , , cord-024189-t7mbsr25 93 5 GCA GCA NNP cord-024189-t7mbsr25 93 6 is be VBZ cord-024189-t7mbsr25 93 7 a a DT cord-024189-t7mbsr25 93 8 systemic systemic JJ cord-024189-t7mbsr25 93 9 infl infl NN cord-024189-t7mbsr25 93 10 ammatory ammatory NN cord-024189-t7mbsr25 93 11 disease disease NN cord-024189-t7mbsr25 93 12 , , , cord-024189-t7mbsr25 93 13 with with IN cord-024189-t7mbsr25 93 14 vasculitis vasculitis NN cord-024189-t7mbsr25 93 15 of of IN cord-024189-t7mbsr25 93 16 medium medium JJ cord-024189-t7mbsr25 93 17 and and CC cord-024189-t7mbsr25 93 18 large large JJ cord-024189-t7mbsr25 93 19 arteries artery NNS cord-024189-t7mbsr25 93 20 as as IN cord-024189-t7mbsr25 93 21 a a DT cord-024189-t7mbsr25 93 22 consequence consequence NN cord-024189-t7mbsr25 93 23 of of IN cord-024189-t7mbsr25 93 24 the the DT cord-024189-t7mbsr25 93 25 disease disease NN cord-024189-t7mbsr25 93 26 process process NN cord-024189-t7mbsr25 93 27 . . . cord-024189-t7mbsr25 94 1 Age age NN cord-024189-t7mbsr25 94 2 is be VBZ cord-024189-t7mbsr25 94 3 the the DT cord-024189-t7mbsr25 94 4 major major JJ cord-024189-t7mbsr25 94 5 risk risk NN cord-024189-t7mbsr25 94 6 factor factor NN cord-024189-t7mbsr25 94 7 for for IN cord-024189-t7mbsr25 94 8 GCA GCA NNP cord-024189-t7mbsr25 94 9 . . . cord-024189-t7mbsr25 95 1 No no DT cord-024189-t7mbsr25 95 2 other other JJ cord-024189-t7mbsr25 95 3 environmental environmental JJ cord-024189-t7mbsr25 95 4 risk risk NN cord-024189-t7mbsr25 95 5 factors factor NNS cord-024189-t7mbsr25 95 6 , , , cord-024189-t7mbsr25 95 7 including include VBG cord-024189-t7mbsr25 95 8 a a DT cord-024189-t7mbsr25 95 9 variety variety NN cord-024189-t7mbsr25 95 10 of of IN cord-024189-t7mbsr25 95 11 infectious infectious JJ cord-024189-t7mbsr25 95 12 agents agent NNS cord-024189-t7mbsr25 95 13 , , , cord-024189-t7mbsr25 95 14 have have VBP cord-024189-t7mbsr25 95 15 been be VBN cord-024189-t7mbsr25 95 16 demonstrated demonstrate VBN cord-024189-t7mbsr25 95 17 convincingly convincingly RB cord-024189-t7mbsr25 95 18 to to TO cord-024189-t7mbsr25 95 19 play play VB cord-024189-t7mbsr25 95 20 important important JJ cord-024189-t7mbsr25 95 21 roles role NNS cord-024189-t7mbsr25 95 22 in in IN cord-024189-t7mbsr25 95 23 this this DT cord-024189-t7mbsr25 95 24 disease disease NN cord-024189-t7mbsr25 95 25 . . . cord-024189-t7mbsr25 96 1 The the DT cord-024189-t7mbsr25 96 2 high high JJ cord-024189-t7mbsr25 96 3 incidence incidence NN cord-024189-t7mbsr25 96 4 rates rate NNS cord-024189-t7mbsr25 96 5 of of IN cord-024189-t7mbsr25 96 6 GCA GCA NNP cord-024189-t7mbsr25 96 7 in in IN cord-024189-t7mbsr25 96 8 all all DT cord-024189-t7mbsr25 96 9 geographical geographical JJ cord-024189-t7mbsr25 96 10 regions region NNS cord-024189-t7mbsr25 96 11 settled settle VBN cord-024189-t7mbsr25 96 12 by by IN cord-024189-t7mbsr25 96 13 people people NNS cord-024189-t7mbsr25 96 14 of of IN cord-024189-t7mbsr25 96 15 Scandinavian scandinavian JJ cord-024189-t7mbsr25 96 16 ethnicity ethnicity NN cord-024189-t7mbsr25 96 17 strongly strongly RB cord-024189-t7mbsr25 96 18 suggest suggest VBP cord-024189-t7mbsr25 96 19 inherited inherit VBN cord-024189-t7mbsr25 96 20 risk risk NN cord-024189-t7mbsr25 96 21 factors factor NNS cord-024189-t7mbsr25 96 22 ( ( -LRB- cord-024189-t7mbsr25 96 23 1 1 CD cord-024189-t7mbsr25 96 24 ) ) -RRB- cord-024189-t7mbsr25 96 25 . . . cord-024189-t7mbsr25 97 1 The the DT cord-024189-t7mbsr25 97 2 best well RBS cord-024189-t7mbsr25 97 3 available available JJ cord-024189-t7mbsr25 97 4 information information NN cord-024189-t7mbsr25 97 5 is be VBZ cord-024189-t7mbsr25 97 6 for for IN cord-024189-t7mbsr25 97 7 human human JJ cord-024189-t7mbsr25 97 8 leukocyte leukocyte NN cord-024189-t7mbsr25 97 9 antigen antigen NN cord-024189-t7mbsr25 97 10 ( ( -LRB- cord-024189-t7mbsr25 97 11 HLA HLA NNP cord-024189-t7mbsr25 97 12 ) ) -RRB- cord-024189-t7mbsr25 97 13 genes gene NNS cord-024189-t7mbsr25 97 14 . . . cord-024189-t7mbsr25 98 1 HLA HLA NNP cord-024189-t7mbsr25 98 2 - - HYPH cord-024189-t7mbsr25 98 3 DR4 DR4 NNP cord-024189-t7mbsr25 98 4 haplotypes haplotype NNS cord-024189-t7mbsr25 98 5 are be VBP cord-024189-t7mbsr25 98 6 associated associate VBN cord-024189-t7mbsr25 98 7 with with IN cord-024189-t7mbsr25 98 8 increased increase VBN cord-024189-t7mbsr25 98 9 disease disease NN cord-024189-t7mbsr25 98 10 risk risk NN cord-024189-t7mbsr25 98 11 . . . cord-024189-t7mbsr25 99 1 Several several JJ cord-024189-t7mbsr25 99 2 allelic allelic JJ cord-024189-t7mbsr25 99 3 variants variant NNS cord-024189-t7mbsr25 99 4 of of IN cord-024189-t7mbsr25 99 5 HLA HLA NNP cord-024189-t7mbsr25 99 6 - - HYPH cord-024189-t7mbsr25 99 7 DR4 DR4 NNP cord-024189-t7mbsr25 99 8 are be VBP cord-024189-t7mbsr25 99 9 enriched enrich VBN cord-024189-t7mbsr25 99 10 among among IN cord-024189-t7mbsr25 99 11 patients patient NNS cord-024189-t7mbsr25 99 12 . . . cord-024189-t7mbsr25 100 1 Selective selective JJ cord-024189-t7mbsr25 100 2 binding binding NN cord-024189-t7mbsr25 100 3 of of IN cord-024189-t7mbsr25 100 4 antigenic antigenic JJ cord-024189-t7mbsr25 100 5 peptides peptide NNS cord-024189-t7mbsr25 100 6 has have VBZ cord-024189-t7mbsr25 100 7 been be VBN cord-024189-t7mbsr25 100 8 proposed propose VBN cord-024189-t7mbsr25 100 9 as as IN cord-024189-t7mbsr25 100 10 the the DT cord-024189-t7mbsr25 100 11 mechanism mechanism NN cord-024189-t7mbsr25 100 12 underlying underlie VBG cord-024189-t7mbsr25 100 13 this this DT cord-024189-t7mbsr25 100 14 genetic genetic JJ cord-024189-t7mbsr25 100 15 association association NN cord-024189-t7mbsr25 100 16 . . . cord-024189-t7mbsr25 101 1 In in IN cord-024189-t7mbsr25 101 2 contrast contrast NN cord-024189-t7mbsr25 101 3 to to IN cord-024189-t7mbsr25 101 4 other other JJ cord-024189-t7mbsr25 101 5 HLA HLA NNP cord-024189-t7mbsr25 101 6 - - HYPH cord-024189-t7mbsr25 101 7 DR4-associated dr4-associate VBN cord-024189-t7mbsr25 101 8 diseases disease NNS cord-024189-t7mbsr25 101 9 such such JJ cord-024189-t7mbsr25 101 10 as as IN cord-024189-t7mbsr25 101 11 rheumatoid rheumatoid JJ cord-024189-t7mbsr25 101 12 arthritis arthritis NN cord-024189-t7mbsr25 101 13 , , , cord-024189-t7mbsr25 101 14 HLA HLA NNP cord-024189-t7mbsr25 101 15 polymorphisms polymorphism NNS cord-024189-t7mbsr25 101 16 do do VBP cord-024189-t7mbsr25 101 17 not not RB cord-024189-t7mbsr25 101 18 correlate correlate VB cord-024189-t7mbsr25 101 19 with with IN cord-024189-t7mbsr25 101 20 clinical clinical JJ cord-024189-t7mbsr25 101 21 phenotypes phenotype NNS cord-024189-t7mbsr25 101 22 and and CC cord-024189-t7mbsr25 101 23 disease disease NN cord-024189-t7mbsr25 101 24 severity severity NN cord-024189-t7mbsr25 101 25 . . . cord-024189-t7mbsr25 102 1 Many many JJ cord-024189-t7mbsr25 102 2 other other JJ cord-024189-t7mbsr25 102 3 genetic genetic JJ cord-024189-t7mbsr25 102 4 risk risk NN cord-024189-t7mbsr25 102 5 factors factor NNS cord-024189-t7mbsr25 102 6 have have VBP cord-024189-t7mbsr25 102 7 been be VBN cord-024189-t7mbsr25 102 8 suggested suggest VBN cord-024189-t7mbsr25 102 9 , , , cord-024189-t7mbsr25 102 10 but but CC cord-024189-t7mbsr25 102 11 none none NN cord-024189-t7mbsr25 102 12 have have VBP cord-024189-t7mbsr25 102 13 been be VBN cord-024189-t7mbsr25 102 14 proven prove VBN cord-024189-t7mbsr25 102 15 to to IN cord-024189-t7mbsr25 102 16 date date NN cord-024189-t7mbsr25 102 17 . . . cord-024189-t7mbsr25 103 1 The the DT cord-024189-t7mbsr25 103 2 diagnostic diagnostic JJ cord-024189-t7mbsr25 103 3 category category NN cord-024189-t7mbsr25 103 4 of of IN cord-024189-t7mbsr25 103 5 GCA GCA NNP cord-024189-t7mbsr25 103 6 encompasses encompass VBZ cord-024189-t7mbsr25 103 7 multiple multiple JJ cord-024189-t7mbsr25 103 8 variants variant NNS cord-024189-t7mbsr25 103 9 ( ( -LRB- cord-024189-t7mbsr25 103 10 Figure figure NN cord-024189-t7mbsr25 103 11 21A-3 21a-3 CD cord-024189-t7mbsr25 103 12 ) ) -RRB- cord-024189-t7mbsr25 103 13 . . . cord-024189-t7mbsr25 104 1 Each each DT cord-024189-t7mbsr25 104 2 of of IN cord-024189-t7mbsr25 104 3 these these DT cord-024189-t7mbsr25 104 4 subtypes subtype NNS cord-024189-t7mbsr25 104 5 has have VBZ cord-024189-t7mbsr25 104 6 characteristic characteristic JJ cord-024189-t7mbsr25 104 7 clinical clinical JJ cord-024189-t7mbsr25 104 8 features feature NNS cord-024189-t7mbsr25 104 9 ( ( -LRB- cord-024189-t7mbsr25 104 10 11 11 CD cord-024189-t7mbsr25 104 11 ) ) -RRB- cord-024189-t7mbsr25 104 12 ; ; : cord-024189-t7mbsr25 104 13 however however RB cord-024189-t7mbsr25 104 14 , , , cord-024189-t7mbsr25 104 15 the the DT cord-024189-t7mbsr25 104 16 clinical clinical JJ cord-024189-t7mbsr25 104 17 manifestations manifestation NNS cord-024189-t7mbsr25 104 18 of of IN cord-024189-t7mbsr25 104 19 the the DT cord-024189-t7mbsr25 104 20 different different JJ cord-024189-t7mbsr25 104 21 subtypes subtype NNS cord-024189-t7mbsr25 104 22 overlap overlap VBP cord-024189-t7mbsr25 104 23 substantially substantially RB cord-024189-t7mbsr25 104 24 , , , cord-024189-t7mbsr25 104 25 and and CC cord-024189-t7mbsr25 104 26 none none NN cord-024189-t7mbsr25 104 27 of of IN cord-024189-t7mbsr25 104 28 the the DT cord-024189-t7mbsr25 104 29 clinical clinical JJ cord-024189-t7mbsr25 104 30 symptoms symptom NNS cord-024189-t7mbsr25 104 31 is be VBZ cord-024189-t7mbsr25 104 32 unique unique JJ cord-024189-t7mbsr25 104 33 for for IN cord-024189-t7mbsr25 104 34 any any DT cord-024189-t7mbsr25 104 35 one one CD cord-024189-t7mbsr25 104 36 of of IN cord-024189-t7mbsr25 104 37 the the DT cord-024189-t7mbsr25 104 38 variants variant NNS cord-024189-t7mbsr25 104 39 . . . cord-024189-t7mbsr25 105 1 Increased increase VBN cord-024189-t7mbsr25 105 2 awareness awareness NN cord-024189-t7mbsr25 105 3 of of IN cord-024189-t7mbsr25 105 4 GCA GCA NNP cord-024189-t7mbsr25 105 5 , , , cord-024189-t7mbsr25 105 6 a a DT cord-024189-t7mbsr25 105 7 growing grow VBG cord-024189-t7mbsr25 105 8 population population NN cord-024189-t7mbsr25 105 9 of of IN cord-024189-t7mbsr25 105 10 individuals individual NNS cord-024189-t7mbsr25 105 11 older old JJR cord-024189-t7mbsr25 105 12 than than IN cord-024189-t7mbsr25 105 13 50 50 CD cord-024189-t7mbsr25 105 14 years year NNS cord-024189-t7mbsr25 105 15 of of IN cord-024189-t7mbsr25 105 16 age age NN cord-024189-t7mbsr25 105 17 , , , cord-024189-t7mbsr25 105 18 and and CC cord-024189-t7mbsr25 105 19 improvement improvement NN cord-024189-t7mbsr25 105 20 in in IN cord-024189-t7mbsr25 105 21 diagnostic diagnostic JJ cord-024189-t7mbsr25 105 22 procedures procedure NNS cord-024189-t7mbsr25 105 23 ( ( -LRB- cord-024189-t7mbsr25 105 24 e.g. e.g. RB cord-024189-t7mbsr25 105 25 , , , cord-024189-t7mbsr25 105 26 the the DT cord-024189-t7mbsr25 105 27 availability availability NN cord-024189-t7mbsr25 105 28 of of IN cord-024189-t7mbsr25 105 29 magnetic magnetic JJ cord-024189-t7mbsr25 105 30 resonance resonance NN cord-024189-t7mbsr25 105 31 angiography angiography NN cord-024189-t7mbsr25 105 32 to to TO cord-024189-t7mbsr25 105 33 image image VB cord-024189-t7mbsr25 105 34 the the DT cord-024189-t7mbsr25 105 35 aorta aorta NN cord-024189-t7mbsr25 105 36 and and CC cord-024189-t7mbsr25 105 37 its -PRON- PRP$ cord-024189-t7mbsr25 105 38 branches branch NNS cord-024189-t7mbsr25 105 39 ) ) -RRB- cord-024189-t7mbsr25 105 40 have have VBP cord-024189-t7mbsr25 105 41 led lead VBN cord-024189-t7mbsr25 105 42 to to IN cord-024189-t7mbsr25 105 43 increased increase VBN cord-024189-t7mbsr25 105 44 detection detection NN cord-024189-t7mbsr25 105 45 of of IN cord-024189-t7mbsr25 105 46 cases case NNS cord-024189-t7mbsr25 105 47 formerly formerly RB cord-024189-t7mbsr25 105 48 considered consider VBN cord-024189-t7mbsr25 105 49 to to TO cord-024189-t7mbsr25 105 50 be be VB cord-024189-t7mbsr25 105 51 atypical atypical JJ cord-024189-t7mbsr25 105 52 presentations presentation NNS cord-024189-t7mbsr25 105 53 . . . cord-024189-t7mbsr25 106 1 Giant giant JJ cord-024189-t7mbsr25 106 2 cell cell NN cord-024189-t7mbsr25 106 3 arteritis arteritis NN cord-024189-t7mbsr25 106 4 presents present VBZ cord-024189-t7mbsr25 106 5 with with IN cord-024189-t7mbsr25 106 6 two two CD cord-024189-t7mbsr25 106 7 major major JJ cord-024189-t7mbsr25 106 8 symptomatic symptomatic JJ cord-024189-t7mbsr25 106 9 complexes complex NNS cord-024189-t7mbsr25 106 10 , , , cord-024189-t7mbsr25 106 11 signs sign NNS cord-024189-t7mbsr25 106 12 of of IN cord-024189-t7mbsr25 106 13 vascular vascular JJ cord-024189-t7mbsr25 106 14 insuffi insuffi NN cord-024189-t7mbsr25 106 15 ciency ciency NN cord-024189-t7mbsr25 106 16 resulting result VBG cord-024189-t7mbsr25 106 17 from from IN cord-024189-t7mbsr25 106 18 impaired impaired JJ cord-024189-t7mbsr25 106 19 blood blood NN cord-024189-t7mbsr25 106 20 fl fl NNP cord-024189-t7mbsr25 106 21 ow ow NN cord-024189-t7mbsr25 106 22 and and CC cord-024189-t7mbsr25 106 23 signs sign NNS cord-024189-t7mbsr25 106 24 of of IN cord-024189-t7mbsr25 106 25 systemic systemic JJ cord-024189-t7mbsr25 106 26 infl infl NN cord-024189-t7mbsr25 106 27 ammation ammation NN cord-024189-t7mbsr25 106 28 . . . cord-024189-t7mbsr25 107 1 In in IN cord-024189-t7mbsr25 107 2 general general JJ cord-024189-t7mbsr25 107 3 , , , cord-024189-t7mbsr25 107 4 vascular vascular JJ cord-024189-t7mbsr25 107 5 changes change NNS cord-024189-t7mbsr25 107 6 are be VBP cord-024189-t7mbsr25 107 7 those those DT cord-024189-t7mbsr25 107 8 of of IN cord-024189-t7mbsr25 107 9 occlusion occlusion NN cord-024189-t7mbsr25 107 10 ; ; : cord-024189-t7mbsr25 107 11 arterial arterial JJ cord-024189-t7mbsr25 107 12 wall wall NN cord-024189-t7mbsr25 107 13 dilatation dilatation NN cord-024189-t7mbsr25 107 14 only only RB cord-024189-t7mbsr25 107 15 occurs occur VBZ cord-024189-t7mbsr25 107 16 when when WRB cord-024189-t7mbsr25 107 17 the the DT cord-024189-t7mbsr25 107 18 aorta aorta NN cord-024189-t7mbsr25 107 19 is be VBZ cord-024189-t7mbsr25 107 20 involved involve VBN cord-024189-t7mbsr25 107 21 . . . cord-024189-t7mbsr25 108 1 Giant giant JJ cord-024189-t7mbsr25 108 2 cell cell NN cord-024189-t7mbsr25 108 3 arteritis arteritis NN cord-024189-t7mbsr25 108 4 , , , cord-024189-t7mbsr25 108 5 also also RB cord-024189-t7mbsr25 108 6 known know VBN cord-024189-t7mbsr25 108 7 as as IN cord-024189-t7mbsr25 108 8 temporal temporal JJ cord-024189-t7mbsr25 108 9 arteritis arteritis NN cord-024189-t7mbsr25 108 10 , , , cord-024189-t7mbsr25 108 11 has have VBZ cord-024189-t7mbsr25 108 12 a a DT cord-024189-t7mbsr25 108 13 predilection predilection NN cord-024189-t7mbsr25 108 14 for for IN cord-024189-t7mbsr25 108 15 involving involve VBG cord-024189-t7mbsr25 108 16 the the DT cord-024189-t7mbsr25 108 17 extracranial extracranial JJ cord-024189-t7mbsr25 108 18 branches branch NNS cord-024189-t7mbsr25 108 19 of of IN cord-024189-t7mbsr25 108 20 the the DT cord-024189-t7mbsr25 108 21 carotid carotid JJ cord-024189-t7mbsr25 108 22 arteries artery NNS cord-024189-t7mbsr25 108 23 . . . cord-024189-t7mbsr25 109 1 The the DT cord-024189-t7mbsr25 109 2 temporal temporal JJ cord-024189-t7mbsr25 109 3 artery artery NN cord-024189-t7mbsr25 109 4 , , , cord-024189-t7mbsr25 109 5 which which WDT cord-024189-t7mbsr25 109 6 courses course VBZ cord-024189-t7mbsr25 109 7 just just RB cord-024189-t7mbsr25 109 8 below below IN cord-024189-t7mbsr25 109 9 the the DT cord-024189-t7mbsr25 109 10 skin skin NN cord-024189-t7mbsr25 109 11 over over IN cord-024189-t7mbsr25 109 12 the the DT cord-024189-t7mbsr25 109 13 temple temple NNP cord-024189-t7mbsr25 109 14 region region NN cord-024189-t7mbsr25 109 15 , , , cord-024189-t7mbsr25 109 16 is be VBZ cord-024189-t7mbsr25 109 17 the the DT cord-024189-t7mbsr25 109 18 vessel vessel NN cord-024189-t7mbsr25 109 19 most most RBS cord-024189-t7mbsr25 109 20 amenable amenable JJ cord-024189-t7mbsr25 109 21 to to IN cord-024189-t7mbsr25 109 22 biopsy biopsy NN cord-024189-t7mbsr25 109 23 . . . cord-024189-t7mbsr25 110 1 In in IN cord-024189-t7mbsr25 110 2 80 80 CD cord-024189-t7mbsr25 110 3 % % NN cord-024189-t7mbsr25 110 4 to to TO cord-024189-t7mbsr25 110 5 90 90 CD cord-024189-t7mbsr25 110 6 % % NN cord-024189-t7mbsr25 110 7 of of IN cord-024189-t7mbsr25 110 8 patients patient NNS cord-024189-t7mbsr25 110 9 , , , cord-024189-t7mbsr25 110 10 histopathology histopathology NN cord-024189-t7mbsr25 110 11 of of IN cord-024189-t7mbsr25 110 12 vasculitis vasculitis NN cord-024189-t7mbsr25 110 13 is be VBZ cord-024189-t7mbsr25 110 14 detected detect VBN cord-024189-t7mbsr25 110 15 in in IN cord-024189-t7mbsr25 110 16 the the DT cord-024189-t7mbsr25 110 17 extracranial extracranial JJ cord-024189-t7mbsr25 110 18 arterial arterial JJ cord-024189-t7mbsr25 110 19 tree tree NN cord-024189-t7mbsr25 110 20 , , , cord-024189-t7mbsr25 110 21 most most RBS cord-024189-t7mbsr25 110 22 often often RB cord-024189-t7mbsr25 110 23 in in IN cord-024189-t7mbsr25 110 24 the the DT cord-024189-t7mbsr25 110 25 superfi superfi NNP cord-024189-t7mbsr25 110 26 cial cial NNP cord-024189-t7mbsr25 110 27 temporal temporal JJ cord-024189-t7mbsr25 110 28 artery artery NN cord-024189-t7mbsr25 110 29 ; ; : cord-024189-t7mbsr25 110 30 the the DT cord-024189-t7mbsr25 110 31 vertebral vertebral JJ cord-024189-t7mbsr25 110 32 , , , cord-024189-t7mbsr25 110 33 ophthalmic ophthalmic NN cord-024189-t7mbsr25 110 34 , , , cord-024189-t7mbsr25 110 35 and and CC cord-024189-t7mbsr25 110 36 posterior posterior JJ cord-024189-t7mbsr25 110 37 ciliary ciliary NN cord-024189-t7mbsr25 110 38 arteries artery NNS cord-024189-t7mbsr25 110 39 ; ; : cord-024189-t7mbsr25 110 40 and and CC cord-024189-t7mbsr25 110 41 , , , cord-024189-t7mbsr25 110 42 less less RBR cord-024189-t7mbsr25 110 43 frequently frequently RB cord-024189-t7mbsr25 110 44 , , , cord-024189-t7mbsr25 110 45 the the DT cord-024189-t7mbsr25 110 46 internal internal JJ cord-024189-t7mbsr25 110 47 and and CC cord-024189-t7mbsr25 110 48 external external JJ cord-024189-t7mbsr25 110 49 carotid carotid NN cord-024189-t7mbsr25 110 50 and and CC cord-024189-t7mbsr25 110 51 central central JJ cord-024189-t7mbsr25 110 52 retinal retinal JJ cord-024189-t7mbsr25 110 53 arteries artery NNS cord-024189-t7mbsr25 110 54 . . . cord-024189-t7mbsr25 111 1 Patients patient NNS cord-024189-t7mbsr25 111 2 complain complain VBP cord-024189-t7mbsr25 111 3 of of IN cord-024189-t7mbsr25 111 4 throbbing throb VBG cord-024189-t7mbsr25 111 5 , , , cord-024189-t7mbsr25 111 6 sharp sharp JJ cord-024189-t7mbsr25 111 7 , , , cord-024189-t7mbsr25 111 8 or or CC cord-024189-t7mbsr25 111 9 dull dull JJ cord-024189-t7mbsr25 111 10 headaches headache NNS cord-024189-t7mbsr25 111 11 that that WDT cord-024189-t7mbsr25 111 12 are be VBP cord-024189-t7mbsr25 111 13 usually usually RB cord-024189-t7mbsr25 111 14 severe severe JJ cord-024189-t7mbsr25 111 15 enough enough RB cord-024189-t7mbsr25 111 16 to to TO cord-024189-t7mbsr25 111 17 prompt prompt VB cord-024189-t7mbsr25 111 18 clinical clinical JJ cord-024189-t7mbsr25 111 19 evaluation evaluation NN cord-024189-t7mbsr25 111 20 . . . cord-024189-t7mbsr25 112 1 The the DT cord-024189-t7mbsr25 112 2 headaches headache NNS cord-024189-t7mbsr25 112 3 may may MD cord-024189-t7mbsr25 112 4 or or CC cord-024189-t7mbsr25 112 5 may may MD cord-024189-t7mbsr25 112 6 not not RB cord-024189-t7mbsr25 112 7 be be VB cord-024189-t7mbsr25 112 8 associated associate VBN cord-024189-t7mbsr25 112 9 with with IN cord-024189-t7mbsr25 112 10 scalp scalp NN cord-024189-t7mbsr25 112 11 tenderness tenderness NN cord-024189-t7mbsr25 112 12 . . . cord-024189-t7mbsr25 113 1 In in IN cord-024189-t7mbsr25 113 2 classic classic JJ cord-024189-t7mbsr25 113 3 cases case NNS cord-024189-t7mbsr25 113 4 , , , cord-024189-t7mbsr25 113 5 the the DT cord-024189-t7mbsr25 113 6 patients patient NNS cord-024189-t7mbsr25 113 7 notice notice VBP cord-024189-t7mbsr25 113 8 temporal temporal JJ cord-024189-t7mbsr25 113 9 tenderness tenderness NN cord-024189-t7mbsr25 113 10 when when WRB cord-024189-t7mbsr25 113 11 wearing wear VBG cord-024189-t7mbsr25 113 12 glasses glass NNS cord-024189-t7mbsr25 113 13 , , , cord-024189-t7mbsr25 113 14 grooming grooming NN cord-024189-t7mbsr25 113 15 , , , cord-024189-t7mbsr25 113 16 or or CC cord-024189-t7mbsr25 113 17 lying lie VBG cord-024189-t7mbsr25 113 18 on on IN cord-024189-t7mbsr25 113 19 a a DT cord-024189-t7mbsr25 113 20 pillow pillow NN cord-024189-t7mbsr25 113 21 . . . cord-024189-t7mbsr25 114 1 On on IN cord-024189-t7mbsr25 114 2 physical physical JJ cord-024189-t7mbsr25 114 3 examination examination NN cord-024189-t7mbsr25 114 4 , , , cord-024189-t7mbsr25 114 5 involved involved JJ cord-024189-t7mbsr25 114 6 vessels vessel NNS cord-024189-t7mbsr25 114 7 may may MD cord-024189-t7mbsr25 114 8 be be VB cord-024189-t7mbsr25 114 9 thickened thicken VBN cord-024189-t7mbsr25 114 10 , , , cord-024189-t7mbsr25 114 11 tender tender JJ cord-024189-t7mbsr25 114 12 , , , cord-024189-t7mbsr25 114 13 and and CC cord-024189-t7mbsr25 114 14 nodular nodular JJ cord-024189-t7mbsr25 114 15 . . . cord-024189-t7mbsr25 115 1 Pulses pulse NNS cord-024189-t7mbsr25 115 2 may may MD cord-024189-t7mbsr25 115 3 be be VB cord-024189-t7mbsr25 115 4 reduced reduce VBN cord-024189-t7mbsr25 115 5 or or CC cord-024189-t7mbsr25 115 6 absent absent JJ cord-024189-t7mbsr25 115 7 . . . cord-024189-t7mbsr25 116 1 Abnormalities abnormality NNS cord-024189-t7mbsr25 116 2 are be VBP cord-024189-t7mbsr25 116 3 most most RBS cord-024189-t7mbsr25 116 4 frequent frequent JJ cord-024189-t7mbsr25 116 5 in in IN cord-024189-t7mbsr25 116 6 the the DT cord-024189-t7mbsr25 116 7 temporal temporal JJ cord-024189-t7mbsr25 116 8 arterial arterial JJ cord-024189-t7mbsr25 116 9 branches branch NNS cord-024189-t7mbsr25 116 10 , , , cord-024189-t7mbsr25 116 11 but but CC cord-024189-t7mbsr25 116 12 they -PRON- PRP cord-024189-t7mbsr25 116 13 can can MD cord-024189-t7mbsr25 116 14 also also RB cord-024189-t7mbsr25 116 15 be be VB cord-024189-t7mbsr25 116 16 detected detect VBN cord-024189-t7mbsr25 116 17 in in IN cord-024189-t7mbsr25 116 18 the the DT cord-024189-t7mbsr25 116 19 occipital occipital JJ cord-024189-t7mbsr25 116 20 arteries artery NNS cord-024189-t7mbsr25 116 21 or or CC cord-024189-t7mbsr25 116 22 other other JJ cord-024189-t7mbsr25 116 23 superfi superfi NNS cord-024189-t7mbsr25 116 24 cial cial JJ cord-024189-t7mbsr25 116 25 scalp scalp NN cord-024189-t7mbsr25 116 26 vessels vessel NNS cord-024189-t7mbsr25 116 27 . . . cord-024189-t7mbsr25 117 1 In in IN cord-024189-t7mbsr25 117 2 one one CD cord-024189-t7mbsr25 117 3 third third NN cord-024189-t7mbsr25 117 4 of of IN cord-024189-t7mbsr25 117 5 the the DT cord-024189-t7mbsr25 117 6 patients patient NNS cord-024189-t7mbsr25 117 7 with with IN cord-024189-t7mbsr25 117 8 biopsy biopsy NN cord-024189-t7mbsr25 117 9 - - HYPH cord-024189-t7mbsr25 117 10 proven prove VBN cord-024189-t7mbsr25 117 11 GCA GCA NNP cord-024189-t7mbsr25 117 12 , , , cord-024189-t7mbsr25 117 13 the the DT cord-024189-t7mbsr25 117 14 temporal temporal JJ cord-024189-t7mbsr25 117 15 arteries artery NNS cord-024189-t7mbsr25 117 16 are be VBP cord-024189-t7mbsr25 117 17 normal normal JJ cord-024189-t7mbsr25 117 18 on on IN cord-024189-t7mbsr25 117 19 physical physical JJ cord-024189-t7mbsr25 117 20 examination examination NN cord-024189-t7mbsr25 117 21 . . . cord-024189-t7mbsr25 118 1 Focal focal JJ cord-024189-t7mbsr25 118 2 arteritic arteritic JJ cord-024189-t7mbsr25 118 3 lesions lesion NNS cord-024189-t7mbsr25 118 4 in in IN cord-024189-t7mbsr25 118 5 the the DT cord-024189-t7mbsr25 118 6 ophthalmic ophthalmic JJ cord-024189-t7mbsr25 118 7 artery artery NN cord-024189-t7mbsr25 118 8 produce produce VBP cord-024189-t7mbsr25 118 9 the the DT cord-024189-t7mbsr25 118 10 most most RBS cord-024189-t7mbsr25 118 11 feared fear VBN cord-024189-t7mbsr25 118 12 complication complication NN cord-024189-t7mbsr25 118 13 of of IN cord-024189-t7mbsr25 118 14 GCA GCA NNP cord-024189-t7mbsr25 118 15 : : : cord-024189-t7mbsr25 118 16 vision vision NN cord-024189-t7mbsr25 118 17 loss loss NN cord-024189-t7mbsr25 118 18 . . . cord-024189-t7mbsr25 119 1 The the DT cord-024189-t7mbsr25 119 2 disease disease NN cord-024189-t7mbsr25 119 3 is be VBZ cord-024189-t7mbsr25 119 4 an an DT cord-024189-t7mbsr25 119 5 ophthalmological ophthalmological JJ cord-024189-t7mbsr25 119 6 emergency emergency NN cord-024189-t7mbsr25 119 7 , , , cord-024189-t7mbsr25 119 8 because because IN cord-024189-t7mbsr25 119 9 prompt prompt JJ cord-024189-t7mbsr25 119 10 recognition recognition NN cord-024189-t7mbsr25 119 11 and and CC cord-024189-t7mbsr25 119 12 treatment treatment NN cord-024189-t7mbsr25 119 13 can can MD cord-024189-t7mbsr25 119 14 prevent prevent VB cord-024189-t7mbsr25 119 15 blindness blindness NN cord-024189-t7mbsr25 119 16 . . . cord-024189-t7mbsr25 120 1 Ischemia ischemia NN cord-024189-t7mbsr25 120 2 anywhere anywhere RB cord-024189-t7mbsr25 120 3 along along IN cord-024189-t7mbsr25 120 4 the the DT cord-024189-t7mbsr25 120 5 visual visual JJ cord-024189-t7mbsr25 120 6 pathway pathway NN cord-024189-t7mbsr25 120 7 can can MD cord-024189-t7mbsr25 120 8 lead lead VB cord-024189-t7mbsr25 120 9 to to IN cord-024189-t7mbsr25 120 10 visual visual JJ cord-024189-t7mbsr25 120 11 loss loss NN cord-024189-t7mbsr25 120 12 , , , cord-024189-t7mbsr25 120 13 but but CC cord-024189-t7mbsr25 120 14 anterior anterior JJ cord-024189-t7mbsr25 120 15 ischemic ischemic JJ cord-024189-t7mbsr25 120 16 optic optic JJ cord-024189-t7mbsr25 120 17 neuropathy neuropathy NN cord-024189-t7mbsr25 120 18 is be VBZ cord-024189-t7mbsr25 120 19 the the DT cord-024189-t7mbsr25 120 20 most most RBS cord-024189-t7mbsr25 120 21 common common JJ cord-024189-t7mbsr25 120 22 cause cause NN cord-024189-t7mbsr25 120 23 . . . cord-024189-t7mbsr25 121 1 Visual visual JJ cord-024189-t7mbsr25 121 2 loss loss NN cord-024189-t7mbsr25 121 3 is be VBZ cord-024189-t7mbsr25 121 4 sudden sudden JJ cord-024189-t7mbsr25 121 5 , , , cord-024189-t7mbsr25 121 6 painless painless JJ cord-024189-t7mbsr25 121 7 , , , cord-024189-t7mbsr25 121 8 and and CC cord-024189-t7mbsr25 121 9 usually usually RB cord-024189-t7mbsr25 121 10 permanent permanent JJ cord-024189-t7mbsr25 121 11 . . . cord-024189-t7mbsr25 122 1 Amaurosis Amaurosis NNP cord-024189-t7mbsr25 122 2 fugax fugax NN cord-024189-t7mbsr25 122 3 , , , cord-024189-t7mbsr25 122 4 reported report VBD cord-024189-t7mbsr25 122 5 as as IN cord-024189-t7mbsr25 122 6 fl fl NNP cord-024189-t7mbsr25 122 7 eeting eete VBG cord-024189-t7mbsr25 122 8 visual visual JJ cord-024189-t7mbsr25 122 9 blurring blurring NN cord-024189-t7mbsr25 122 10 with with IN cord-024189-t7mbsr25 122 11 heat heat NN cord-024189-t7mbsr25 122 12 or or CC cord-024189-t7mbsr25 122 13 exercise exercise NN cord-024189-t7mbsr25 122 14 or or CC cord-024189-t7mbsr25 122 15 posture posture NN cord-024189-t7mbsr25 122 16 - - HYPH cord-024189-t7mbsr25 122 17 related relate VBN cord-024189-t7mbsr25 122 18 visual visual JJ cord-024189-t7mbsr25 122 19 blurring blurring NN cord-024189-t7mbsr25 122 20 and and CC cord-024189-t7mbsr25 122 21 diplopia diplopia NN cord-024189-t7mbsr25 122 22 , , , cord-024189-t7mbsr25 122 23 may may MD cord-024189-t7mbsr25 122 24 precede precede VB cord-024189-t7mbsr25 122 25 partial partial JJ cord-024189-t7mbsr25 122 26 or or CC cord-024189-t7mbsr25 122 27 complete complete JJ cord-024189-t7mbsr25 122 28 blindness blindness NN cord-024189-t7mbsr25 122 29 . . . cord-024189-t7mbsr25 123 1 On on IN cord-024189-t7mbsr25 123 2 ophthalmologic ophthalmologic JJ cord-024189-t7mbsr25 123 3 examination examination NN cord-024189-t7mbsr25 123 4 , , , cord-024189-t7mbsr25 123 5 anterior anterior JJ cord-024189-t7mbsr25 123 6 ischemic ischemic JJ cord-024189-t7mbsr25 123 7 optic optic JJ cord-024189-t7mbsr25 123 8 neuropathy neuropathy NN cord-024189-t7mbsr25 123 9 is be VBZ cord-024189-t7mbsr25 123 10 recognized recognize VBN cord-024189-t7mbsr25 123 11 by by IN cord-024189-t7mbsr25 123 12 optic optic JJ cord-024189-t7mbsr25 123 13 disc disc NN cord-024189-t7mbsr25 123 14 edema edema NN cord-024189-t7mbsr25 123 15 , , , cord-024189-t7mbsr25 123 16 eventually eventually RB cord-024189-t7mbsr25 123 17 followed follow VBN cord-024189-t7mbsr25 123 18 by by IN cord-024189-t7mbsr25 123 19 sectoral sectoral JJ cord-024189-t7mbsr25 123 20 or or CC cord-024189-t7mbsr25 123 21 generalized generalized JJ cord-024189-t7mbsr25 123 22 optic optic JJ cord-024189-t7mbsr25 123 23 atrophy atrophy NN cord-024189-t7mbsr25 123 24 with with IN cord-024189-t7mbsr25 123 25 optic optic JJ cord-024189-t7mbsr25 123 26 disc disc NN cord-024189-t7mbsr25 123 27 cupping cupping NN cord-024189-t7mbsr25 123 28 . . . cord-024189-t7mbsr25 124 1 Besides besides IN cord-024189-t7mbsr25 124 2 optic optic JJ cord-024189-t7mbsr25 124 3 neuropathy neuropathy NN cord-024189-t7mbsr25 124 4 , , , cord-024189-t7mbsr25 124 5 the the DT cord-024189-t7mbsr25 124 6 spectrum spectrum NN cord-024189-t7mbsr25 124 7 of of IN cord-024189-t7mbsr25 124 8 ophthalmic ophthalmic JJ cord-024189-t7mbsr25 124 9 complications complication NNS cord-024189-t7mbsr25 124 10 is be VBZ cord-024189-t7mbsr25 124 11 wide wide JJ cord-024189-t7mbsr25 124 12 , , , cord-024189-t7mbsr25 124 13 ranging range VBG cord-024189-t7mbsr25 124 14 from from IN cord-024189-t7mbsr25 124 15 pupillary pupillary JJ cord-024189-t7mbsr25 124 16 defects defect NNS cord-024189-t7mbsr25 124 17 to to IN cord-024189-t7mbsr25 124 18 orbital orbital JJ cord-024189-t7mbsr25 124 19 ischemia ischemia NN cord-024189-t7mbsr25 124 20 and and CC cord-024189-t7mbsr25 124 21 from from IN cord-024189-t7mbsr25 124 22 ocular ocular JJ cord-024189-t7mbsr25 124 23 motor motor NN cord-024189-t7mbsr25 124 24 ischemia ischemia NN cord-024189-t7mbsr25 124 25 to to IN cord-024189-t7mbsr25 124 26 anterior anterior NNP cord-024189-t7mbsr25 124 27 and and CC cord-024189-t7mbsr25 124 28 posterior posterior JJ cord-024189-t7mbsr25 124 29 segment segment NN cord-024189-t7mbsr25 124 30 ischemia ischemia NN cord-024189-t7mbsr25 124 31 . . . cord-024189-t7mbsr25 125 1 A a DT cord-024189-t7mbsr25 125 2 relatively relatively RB cord-024189-t7mbsr25 125 3 disease disease NN cord-024189-t7mbsr25 125 4 - - HYPH cord-024189-t7mbsr25 125 5 specifi specifi VBN cord-024189-t7mbsr25 125 6 c c NN cord-024189-t7mbsr25 125 7 manifestation manifestation NN cord-024189-t7mbsr25 125 8 of of IN cord-024189-t7mbsr25 125 9 GCA GCA NNP cord-024189-t7mbsr25 125 10 that that WDT cord-024189-t7mbsr25 125 11 is be VBZ cord-024189-t7mbsr25 125 12 present present JJ cord-024189-t7mbsr25 125 13 in in IN cord-024189-t7mbsr25 125 14 about about IN cord-024189-t7mbsr25 125 15 half half NN cord-024189-t7mbsr25 125 16 of of IN cord-024189-t7mbsr25 125 17 the the DT cord-024189-t7mbsr25 125 18 patients patient NNS cord-024189-t7mbsr25 125 19 is be VBZ cord-024189-t7mbsr25 125 20 jaw jaw NNP cord-024189-t7mbsr25 125 21 claudication claudication NN cord-024189-t7mbsr25 125 22 : : : cord-024189-t7mbsr25 125 23 pain pain NN cord-024189-t7mbsr25 125 24 in in IN cord-024189-t7mbsr25 125 25 the the DT cord-024189-t7mbsr25 125 26 masseter masseter NN cord-024189-t7mbsr25 125 27 or or CC cord-024189-t7mbsr25 125 28 temporalis temporalis JJ cord-024189-t7mbsr25 125 29 muscles muscle NNS cord-024189-t7mbsr25 125 30 caused cause VBN cord-024189-t7mbsr25 125 31 by by IN cord-024189-t7mbsr25 125 32 compromised compromised JJ cord-024189-t7mbsr25 125 33 blood blood NN cord-024189-t7mbsr25 125 34 fl fl NNP cord-024189-t7mbsr25 125 35 ow ow NN cord-024189-t7mbsr25 125 36 in in IN cord-024189-t7mbsr25 125 37 the the DT cord-024189-t7mbsr25 125 38 extracranial extracranial JJ cord-024189-t7mbsr25 125 39 branches branch NNS cord-024189-t7mbsr25 125 40 of of IN cord-024189-t7mbsr25 125 41 the the DT cord-024189-t7mbsr25 125 42 carotid carotid JJ cord-024189-t7mbsr25 125 43 artery artery NN cord-024189-t7mbsr25 125 44 . . . cord-024189-t7mbsr25 126 1 Prolonged prolonged JJ cord-024189-t7mbsr25 126 2 talking talk VBG cord-024189-t7mbsr25 126 3 and and CC cord-024189-t7mbsr25 126 4 chewing chew VBG cord-024189-t7mbsr25 126 5 produce produce VBP cord-024189-t7mbsr25 126 6 pain pain NN cord-024189-t7mbsr25 126 7 in in IN cord-024189-t7mbsr25 126 8 the the DT cord-024189-t7mbsr25 126 9 muscles muscle NNS cord-024189-t7mbsr25 126 10 of of IN cord-024189-t7mbsr25 126 11 mastication mastication NN cord-024189-t7mbsr25 126 12 . . . cord-024189-t7mbsr25 127 1 The the DT cord-024189-t7mbsr25 127 2 onset onset NN cord-024189-t7mbsr25 127 3 of of IN cord-024189-t7mbsr25 127 4 jaw jaw NN cord-024189-t7mbsr25 127 5 claudication claudication NN cord-024189-t7mbsr25 127 6 following follow VBG cord-024189-t7mbsr25 127 7 the the DT cord-024189-t7mbsr25 127 8 initiation initiation NN cord-024189-t7mbsr25 127 9 of of IN cord-024189-t7mbsr25 127 10 chewing chewing NN cord-024189-t7mbsr25 127 11 is be VBZ cord-024189-t7mbsr25 127 12 surprisingly surprisingly RB cord-024189-t7mbsr25 127 13 swift swift JJ cord-024189-t7mbsr25 127 14 . . . cord-024189-t7mbsr25 128 1 Cases case NNS cord-024189-t7mbsr25 128 2 of of IN cord-024189-t7mbsr25 128 3 trismus trismus NNP cord-024189-t7mbsr25 128 4 have have VBP cord-024189-t7mbsr25 128 5 been be VBN cord-024189-t7mbsr25 128 6 described describe VBN cord-024189-t7mbsr25 128 7 . . . cord-024189-t7mbsr25 129 1 Claudication claudication NN cord-024189-t7mbsr25 129 2 of of IN cord-024189-t7mbsr25 129 3 the the DT cord-024189-t7mbsr25 129 4 tongue tongue NN cord-024189-t7mbsr25 129 5 is be VBZ cord-024189-t7mbsr25 129 6 less less RBR cord-024189-t7mbsr25 129 7 frequent frequent JJ cord-024189-t7mbsr25 129 8 , , , cord-024189-t7mbsr25 129 9 but but CC cord-024189-t7mbsr25 129 10 tongue tongue NN cord-024189-t7mbsr25 129 11 infarctions infarction NNS cord-024189-t7mbsr25 129 12 have have VBP cord-024189-t7mbsr25 129 13 been be VBN cord-024189-t7mbsr25 129 14 reported report VBN cord-024189-t7mbsr25 129 15 . . . cord-024189-t7mbsr25 130 1 Vasoocclusive Vasoocclusive NNP cord-024189-t7mbsr25 130 2 disease disease NN cord-024189-t7mbsr25 130 3 of of IN cord-024189-t7mbsr25 130 4 the the DT cord-024189-t7mbsr25 130 5 carotid carotid NN cord-024189-t7mbsr25 130 6 and and CC cord-024189-t7mbsr25 130 7 vertebrobasilar vertebrobasilar JJ cord-024189-t7mbsr25 130 8 arteries artery NNS cord-024189-t7mbsr25 130 9 results result VBZ cord-024189-t7mbsr25 130 10 in in IN cord-024189-t7mbsr25 130 11 ischemia ischemia NN cord-024189-t7mbsr25 130 12 of of IN cord-024189-t7mbsr25 130 13 the the DT cord-024189-t7mbsr25 130 14 central central JJ cord-024189-t7mbsr25 130 15 nervous nervous JJ cord-024189-t7mbsr25 130 16 system system NN cord-024189-t7mbsr25 130 17 ( ( -LRB- cord-024189-t7mbsr25 130 18 CNS CNS NNP cord-024189-t7mbsr25 130 19 ) ) -RRB- cord-024189-t7mbsr25 130 20 , , , cord-024189-t7mbsr25 130 21 manifesting manifest VBG cord-024189-t7mbsr25 130 22 as as IN cord-024189-t7mbsr25 130 23 transient transient JJ cord-024189-t7mbsr25 130 24 ischemic ischemic JJ cord-024189-t7mbsr25 130 25 attacks attack NNS cord-024189-t7mbsr25 130 26 or or CC cord-024189-t7mbsr25 130 27 infarcts infarct NNS cord-024189-t7mbsr25 130 28 . . . cord-024189-t7mbsr25 131 1 Neurologic neurologic JJ cord-024189-t7mbsr25 131 2 manifestations manifestation NNS cord-024189-t7mbsr25 131 3 are be VBP cord-024189-t7mbsr25 131 4 increasingly increasingly RB cord-024189-t7mbsr25 131 5 being be VBG cord-024189-t7mbsr25 131 6 recognized recognize VBN cord-024189-t7mbsr25 131 7 and and CC cord-024189-t7mbsr25 131 8 can can MD cord-024189-t7mbsr25 131 9 be be VB cord-024189-t7mbsr25 131 10 expected expect VBN cord-024189-t7mbsr25 131 11 in in IN cord-024189-t7mbsr25 131 12 20 20 CD cord-024189-t7mbsr25 131 13 % % NN cord-024189-t7mbsr25 131 14 to to TO cord-024189-t7mbsr25 131 15 30 30 CD cord-024189-t7mbsr25 131 16 % % NN cord-024189-t7mbsr25 131 17 of of IN cord-024189-t7mbsr25 131 18 patients patient NNS cord-024189-t7mbsr25 131 19 . . . cord-024189-t7mbsr25 132 1 True true JJ cord-024189-t7mbsr25 132 2 intraparenchymal intraparenchymal JJ cord-024189-t7mbsr25 132 3 CNS CNS NNP cord-024189-t7mbsr25 132 4 vasculitis vasculitis NN cord-024189-t7mbsr25 132 5 in in IN cord-024189-t7mbsr25 132 6 GCA GCA NNP cord-024189-t7mbsr25 132 7 is be VBZ cord-024189-t7mbsr25 132 8 rare rare JJ cord-024189-t7mbsr25 132 9 , , , cord-024189-t7mbsr25 132 10 but but CC cord-024189-t7mbsr25 132 11 reported report VBN cord-024189-t7mbsr25 132 12 . . . cord-024189-t7mbsr25 133 1 Occult occult JJ cord-024189-t7mbsr25 133 2 presentations presentation NNS cord-024189-t7mbsr25 133 3 of of IN cord-024189-t7mbsr25 133 4 GCA GCA NNP cord-024189-t7mbsr25 133 5 are be VBP cord-024189-t7mbsr25 133 6 common common JJ cord-024189-t7mbsr25 133 7 . . . cord-024189-t7mbsr25 134 1 GCA GCA NNP cord-024189-t7mbsr25 134 2 is be VBZ cord-024189-t7mbsr25 134 3 the the DT cord-024189-t7mbsr25 134 4 cause cause NN cord-024189-t7mbsr25 134 5 of of IN cord-024189-t7mbsr25 134 6 fever fever NN cord-024189-t7mbsr25 134 7 of of IN cord-024189-t7mbsr25 134 8 unknown unknown JJ cord-024189-t7mbsr25 134 9 origin origin NN cord-024189-t7mbsr25 134 10 in in IN cord-024189-t7mbsr25 134 11 up up IN cord-024189-t7mbsr25 134 12 to to TO cord-024189-t7mbsr25 134 13 15 15 CD cord-024189-t7mbsr25 134 14 % % NN cord-024189-t7mbsr25 134 15 of of IN cord-024189-t7mbsr25 134 16 elderly elderly JJ cord-024189-t7mbsr25 134 17 individuals individual NNS cord-024189-t7mbsr25 134 18 , , , cord-024189-t7mbsr25 134 19 for for IN cord-024189-t7mbsr25 134 20 example example NN cord-024189-t7mbsr25 134 21 . . . cord-024189-t7mbsr25 135 1 Nonspecifi nonspecifi NN cord-024189-t7mbsr25 135 2 c c NN cord-024189-t7mbsr25 135 3 symptoms symptom NNS cord-024189-t7mbsr25 135 4 of of IN cord-024189-t7mbsr25 135 5 pain pain NN cord-024189-t7mbsr25 135 6 in in IN cord-024189-t7mbsr25 135 7 the the DT cord-024189-t7mbsr25 135 8 face face NN cord-024189-t7mbsr25 135 9 , , , cord-024189-t7mbsr25 135 10 neck neck NN cord-024189-t7mbsr25 135 11 , , , cord-024189-t7mbsr25 135 12 or or CC cord-024189-t7mbsr25 135 13 throat throat NN cord-024189-t7mbsr25 135 14 are be VBP cord-024189-t7mbsr25 135 15 other other JJ cord-024189-t7mbsr25 135 16 warning warn VBG cord-024189-t7mbsr25 135 17 signs sign NNS cord-024189-t7mbsr25 135 18 of of IN cord-024189-t7mbsr25 135 19 possible possible JJ cord-024189-t7mbsr25 135 20 GCA GCA NNP cord-024189-t7mbsr25 135 21 . . . cord-024189-t7mbsr25 136 1 Chronic chronic JJ cord-024189-t7mbsr25 136 2 nonproductive nonproductive JJ cord-024189-t7mbsr25 136 3 cough cough NN cord-024189-t7mbsr25 136 4 can can MD cord-024189-t7mbsr25 136 5 be be VB cord-024189-t7mbsr25 136 6 an an DT cord-024189-t7mbsr25 136 7 initial initial JJ cord-024189-t7mbsr25 136 8 presentation presentation NN cord-024189-t7mbsr25 136 9 of of IN cord-024189-t7mbsr25 136 10 GCA GCA NNP cord-024189-t7mbsr25 136 11 . . . cord-024189-t7mbsr25 137 1 The the DT cord-024189-t7mbsr25 137 2 involvement involvement NN cord-024189-t7mbsr25 137 3 of of IN cord-024189-t7mbsr25 137 4 cough cough NN cord-024189-t7mbsr25 137 5 receptors receptor NNS cord-024189-t7mbsr25 137 6 ( ( -LRB- cord-024189-t7mbsr25 137 7 present present JJ cord-024189-t7mbsr25 137 8 throughout throughout IN cord-024189-t7mbsr25 137 9 the the DT cord-024189-t7mbsr25 137 10 repiratory repiratory NN cord-024189-t7mbsr25 137 11 tree tree NN cord-024189-t7mbsr25 137 12 ) ) -RRB- cord-024189-t7mbsr25 137 13 by by IN cord-024189-t7mbsr25 137 14 the the DT cord-024189-t7mbsr25 137 15 vasculitic vasculitic JJ cord-024189-t7mbsr25 137 16 process process NN cord-024189-t7mbsr25 137 17 is be VBZ cord-024189-t7mbsr25 137 18 believed believe VBN cord-024189-t7mbsr25 137 19 to to TO cord-024189-t7mbsr25 137 20 be be VB cord-024189-t7mbsr25 137 21 the the DT cord-024189-t7mbsr25 137 22 cause cause NN cord-024189-t7mbsr25 137 23 of of IN cord-024189-t7mbsr25 137 24 cough cough NN cord-024189-t7mbsr25 137 25 in in IN cord-024189-t7mbsr25 137 26 GCA GCA NNP cord-024189-t7mbsr25 137 27 . . . cord-024189-t7mbsr25 138 1 Symptoms symptom NNS cord-024189-t7mbsr25 138 2 related relate VBN cord-024189-t7mbsr25 138 3 to to IN cord-024189-t7mbsr25 138 4 systemic systemic JJ cord-024189-t7mbsr25 138 5 infl infl NN cord-024189-t7mbsr25 138 6 ammation ammation NN cord-024189-t7mbsr25 138 7 are be VBP cord-024189-t7mbsr25 138 8 frequently frequently RB cord-024189-t7mbsr25 138 9 present present JJ cord-024189-t7mbsr25 138 10 . . . cord-024189-t7mbsr25 139 1 Laboratory laboratory NN cord-024189-t7mbsr25 139 2 abnormalities abnormality NNS cord-024189-t7mbsr25 139 3 are be VBP cord-024189-t7mbsr25 139 4 detectable detectable JJ cord-024189-t7mbsr25 139 5 in in IN cord-024189-t7mbsr25 139 6 more more JJR cord-024189-t7mbsr25 139 7 than than IN cord-024189-t7mbsr25 139 8 90 90 CD cord-024189-t7mbsr25 139 9 % % NN cord-024189-t7mbsr25 139 10 of of IN cord-024189-t7mbsr25 139 11 patients patient NNS cord-024189-t7mbsr25 139 12 . . . cord-024189-t7mbsr25 140 1 In in IN cord-024189-t7mbsr25 140 2 a a DT cord-024189-t7mbsr25 140 3 subset subset NN cord-024189-t7mbsr25 140 4 of of IN cord-024189-t7mbsr25 140 5 patients patient NNS cord-024189-t7mbsr25 140 6 , , , cord-024189-t7mbsr25 140 7 the the DT cord-024189-t7mbsr25 140 8 disease disease NN cord-024189-t7mbsr25 140 9 process process NN cord-024189-t7mbsr25 140 10 is be VBZ cord-024189-t7mbsr25 140 11 dominated dominate VBN cord-024189-t7mbsr25 140 12 by by IN cord-024189-t7mbsr25 140 13 a a DT cord-024189-t7mbsr25 140 14 systemic systemic JJ cord-024189-t7mbsr25 140 15 infl infl NNP cord-024189-t7mbsr25 140 16 ammatory ammatory NNP cord-024189-t7mbsr25 140 17 syndrome syndrome NN cord-024189-t7mbsr25 140 18 . . . cord-024189-t7mbsr25 141 1 Fever fever NN cord-024189-t7mbsr25 141 2 of of IN cord-024189-t7mbsr25 141 3 unknown unknown JJ cord-024189-t7mbsr25 141 4 origin origin NN cord-024189-t7mbsr25 141 5 with with IN cord-024189-t7mbsr25 141 6 spiking spike VBG cord-024189-t7mbsr25 141 7 temperatures temperature NNS cord-024189-t7mbsr25 141 8 and and CC cord-024189-t7mbsr25 141 9 chills chill NNS cord-024189-t7mbsr25 141 10 usually usually RB cord-024189-t7mbsr25 141 11 leads lead VBZ cord-024189-t7mbsr25 141 12 to to IN cord-024189-t7mbsr25 141 13 diagnostic diagnostic JJ cord-024189-t7mbsr25 141 14 evaluations evaluation NNS cord-024189-t7mbsr25 141 15 designed design VBN cord-024189-t7mbsr25 141 16 to to TO cord-024189-t7mbsr25 141 17 exclude exclude VB cord-024189-t7mbsr25 141 18 infections infection NNS cord-024189-t7mbsr25 141 19 and and CC cord-024189-t7mbsr25 141 20 malignancies malignancy NNS cord-024189-t7mbsr25 141 21 . . . cord-024189-t7mbsr25 142 1 In in IN cord-024189-t7mbsr25 142 2 less less RBR cord-024189-t7mbsr25 142 3 dramatic dramatic JJ cord-024189-t7mbsr25 142 4 cases case NNS cord-024189-t7mbsr25 142 5 , , , cord-024189-t7mbsr25 142 6 malaise malaise NN cord-024189-t7mbsr25 142 7 , , , cord-024189-t7mbsr25 142 8 anorexia anorexia NN cord-024189-t7mbsr25 142 9 , , , cord-024189-t7mbsr25 142 10 weight weight NN cord-024189-t7mbsr25 142 11 loss loss NN cord-024189-t7mbsr25 142 12 , , , cord-024189-t7mbsr25 142 13 low low JJ cord-024189-t7mbsr25 142 14 - - HYPH cord-024189-t7mbsr25 142 15 grade grade NN cord-024189-t7mbsr25 142 16 fever fever NN cord-024189-t7mbsr25 142 17 , , , cord-024189-t7mbsr25 142 18 and and CC cord-024189-t7mbsr25 142 19 fatigue fatigue NN cord-024189-t7mbsr25 142 20 eventually eventually RB cord-024189-t7mbsr25 142 21 become become VBP cord-024189-t7mbsr25 142 22 severe severe JJ cord-024189-t7mbsr25 142 23 enough enough RB cord-024189-t7mbsr25 142 24 to to TO cord-024189-t7mbsr25 142 25 prompt prompt VB cord-024189-t7mbsr25 142 26 medical medical JJ cord-024189-t7mbsr25 142 27 attention attention NN cord-024189-t7mbsr25 142 28 . . . cord-024189-t7mbsr25 143 1 Physical physical JJ cord-024189-t7mbsr25 143 2 examination examination NN cord-024189-t7mbsr25 143 3 of of IN cord-024189-t7mbsr25 143 4 the the DT cord-024189-t7mbsr25 143 5 scalp scalp NN cord-024189-t7mbsr25 143 6 arteries artery NNS cord-024189-t7mbsr25 143 7 is be VBZ cord-024189-t7mbsr25 143 8 often often RB cord-024189-t7mbsr25 143 9 negative negative JJ cord-024189-t7mbsr25 143 10 , , , cord-024189-t7mbsr25 143 11 and and CC cord-024189-t7mbsr25 143 12 symptoms symptom NNS cord-024189-t7mbsr25 143 13 of of IN cord-024189-t7mbsr25 143 14 vascular vascular JJ cord-024189-t7mbsr25 143 15 insuffi insuffi NN cord-024189-t7mbsr25 143 16 ciency ciency NN cord-024189-t7mbsr25 143 17 can can MD cord-024189-t7mbsr25 143 18 be be VB cord-024189-t7mbsr25 143 19 absent absent JJ cord-024189-t7mbsr25 143 20 . . . cord-024189-t7mbsr25 144 1 Temporal temporal JJ cord-024189-t7mbsr25 144 2 artery artery NN cord-024189-t7mbsr25 144 3 biopsy biopsy NN cord-024189-t7mbsr25 144 4 , , , cord-024189-t7mbsr25 144 5 even even RB cord-024189-t7mbsr25 144 6 if if IN cord-024189-t7mbsr25 144 7 the the DT cord-024189-t7mbsr25 144 8 artery artery NN cord-024189-t7mbsr25 144 9 is be VBZ cord-024189-t7mbsr25 144 10 normal normal JJ cord-024189-t7mbsr25 144 11 on on IN cord-024189-t7mbsr25 144 12 clinical clinical JJ cord-024189-t7mbsr25 144 13 examination examination NN cord-024189-t7mbsr25 144 14 , , , cord-024189-t7mbsr25 144 15 remains remain VBZ cord-024189-t7mbsr25 144 16 the the DT cord-024189-t7mbsr25 144 17 diagnostic diagnostic JJ cord-024189-t7mbsr25 144 18 procedure procedure NN cord-024189-t7mbsr25 144 19 of of IN cord-024189-t7mbsr25 144 20 choice choice NN cord-024189-t7mbsr25 144 21 . . . cord-024189-t7mbsr25 145 1 Clinical clinical JJ cord-024189-t7mbsr25 145 2 spectrum spectrum NN cord-024189-t7mbsr25 145 3 of of IN cord-024189-t7mbsr25 145 4 the the DT cord-024189-t7mbsr25 145 5 giant giant JJ cord-024189-t7mbsr25 145 6 cell cell NN cord-024189-t7mbsr25 145 7 arteritis/ arteritis/ CD cord-024189-t7mbsr25 145 8 polymyalgia polymyalgia NNP cord-024189-t7mbsr25 145 9 rheumatica rheumatica NNP cord-024189-t7mbsr25 145 10 syndrome syndrome NNP cord-024189-t7mbsr25 145 11 . . . cord-024189-t7mbsr25 146 1 In in IN cord-024189-t7mbsr25 146 2 at at RB cord-024189-t7mbsr25 146 3 least least RBS cord-024189-t7mbsr25 146 4 10 10 CD cord-024189-t7mbsr25 146 5 % % NN cord-024189-t7mbsr25 146 6 to to TO cord-024189-t7mbsr25 146 7 15 15 CD cord-024189-t7mbsr25 146 8 % % NN cord-024189-t7mbsr25 146 9 of of IN cord-024189-t7mbsr25 146 10 patients patient NNS cord-024189-t7mbsr25 146 11 , , , cord-024189-t7mbsr25 146 12 GCA GCA NNP cord-024189-t7mbsr25 146 13 involves involve VBZ cord-024189-t7mbsr25 146 14 the the DT cord-024189-t7mbsr25 146 15 large large JJ cord-024189-t7mbsr25 146 16 arteries artery NNS cord-024189-t7mbsr25 146 17 in in IN cord-024189-t7mbsr25 146 18 a a DT cord-024189-t7mbsr25 146 19 clinically clinically RB cord-024189-t7mbsr25 146 20 evident evident JJ cord-024189-t7mbsr25 146 21 manner manner NN cord-024189-t7mbsr25 146 22 . . . cord-024189-t7mbsr25 147 1 ( ( -LRB- cord-024189-t7mbsr25 147 2 The the DT cord-024189-t7mbsr25 147 3 percentage percentage NN cord-024189-t7mbsr25 147 4 of of IN cord-024189-t7mbsr25 147 5 cases case NNS cord-024189-t7mbsr25 147 6 with with IN cord-024189-t7mbsr25 147 7 subclinical subclinical JJ cord-024189-t7mbsr25 147 8 large large JJ cord-024189-t7mbsr25 147 9 vessel vessel NN cord-024189-t7mbsr25 147 10 disease disease NN cord-024189-t7mbsr25 147 11 may may MD cord-024189-t7mbsr25 147 12 be be VB cord-024189-t7mbsr25 147 13 substantially substantially RB cord-024189-t7mbsr25 147 14 higher high JJR cord-024189-t7mbsr25 147 15 . . . cord-024189-t7mbsr25 147 16 ) ) -RRB- cord-024189-t7mbsr25 148 1 Preferred preferred JJ cord-024189-t7mbsr25 148 2 vascular vascular JJ cord-024189-t7mbsr25 148 3 beds bed NNS cord-024189-t7mbsr25 148 4 are be VBP cord-024189-t7mbsr25 148 5 the the DT cord-024189-t7mbsr25 148 6 carotid carotid JJ cord-024189-t7mbsr25 148 7 , , , cord-024189-t7mbsr25 148 8 subclavian subclavian JJ cord-024189-t7mbsr25 148 9 , , , cord-024189-t7mbsr25 148 10 and and CC cord-024189-t7mbsr25 148 11 axillary axillary JJ cord-024189-t7mbsr25 148 12 arteries artery NNS cord-024189-t7mbsr25 148 13 . . . cord-024189-t7mbsr25 149 1 Vasculitis vasculitis NN cord-024189-t7mbsr25 149 2 of of IN cord-024189-t7mbsr25 149 3 the the DT cord-024189-t7mbsr25 149 4 femoral femoral JJ cord-024189-t7mbsr25 149 5 arteries artery NNS cord-024189-t7mbsr25 149 6 is be VBZ cord-024189-t7mbsr25 149 7 infrequent infrequent JJ cord-024189-t7mbsr25 149 8 . . . cord-024189-t7mbsr25 150 1 The the DT cord-024189-t7mbsr25 150 2 major major JJ cord-024189-t7mbsr25 150 3 clinical clinical JJ cord-024189-t7mbsr25 150 4 presentation presentation NN cord-024189-t7mbsr25 150 5 is be VBZ cord-024189-t7mbsr25 150 6 that that DT cord-024189-t7mbsr25 150 7 of of IN cord-024189-t7mbsr25 150 8 aortic aortic JJ cord-024189-t7mbsr25 150 9 arch arch JJ cord-024189-t7mbsr25 150 10 syndrome syndrome NN cord-024189-t7mbsr25 150 11 , , , cord-024189-t7mbsr25 150 12 producing produce VBG cord-024189-t7mbsr25 150 13 claudication claudication NN cord-024189-t7mbsr25 150 14 of of IN cord-024189-t7mbsr25 150 15 the the DT cord-024189-t7mbsr25 150 16 arms arm NNS cord-024189-t7mbsr25 150 17 , , , cord-024189-t7mbsr25 150 18 absent absent JJ cord-024189-t7mbsr25 150 19 or or CC cord-024189-t7mbsr25 150 20 asymmetrical asymmetrical JJ cord-024189-t7mbsr25 150 21 pulses pulse NNS cord-024189-t7mbsr25 150 22 , , , cord-024189-t7mbsr25 150 23 paresthesias paresthesia NNS cord-024189-t7mbsr25 150 24 , , , cord-024189-t7mbsr25 150 25 and and CC cord-024189-t7mbsr25 150 26 ( ( -LRB- cord-024189-t7mbsr25 150 27 rarely rarely RB cord-024189-t7mbsr25 150 28 ) ) -RRB- cord-024189-t7mbsr25 150 29 symptoms symptom NNS cord-024189-t7mbsr25 150 30 of of IN cord-024189-t7mbsr25 150 31 digital digital JJ cord-024189-t7mbsr25 150 32 ischemia ischemia NN cord-024189-t7mbsr25 150 33 . . . cord-024189-t7mbsr25 151 1 Patients patient NNS cord-024189-t7mbsr25 151 2 with with IN cord-024189-t7mbsr25 151 3 the the DT cord-024189-t7mbsr25 151 4 large large JJ cord-024189-t7mbsr25 151 5 vessel vessel NN cord-024189-t7mbsr25 151 6 variant variant NN cord-024189-t7mbsr25 151 7 of of IN cord-024189-t7mbsr25 151 8 GCA GCA NNP cord-024189-t7mbsr25 151 9 often often RB cord-024189-t7mbsr25 151 10 lack lack VBP cord-024189-t7mbsr25 151 11 evidence evidence NN cord-024189-t7mbsr25 151 12 of of IN cord-024189-t7mbsr25 151 13 cranial cranial JJ cord-024189-t7mbsr25 151 14 involvement involvement NN cord-024189-t7mbsr25 151 15 ; ; : cord-024189-t7mbsr25 151 16 they -PRON- PRP cord-024189-t7mbsr25 151 17 do do VBP cord-024189-t7mbsr25 151 18 not not RB cord-024189-t7mbsr25 151 19 complain complain VB cord-024189-t7mbsr25 151 20 about about IN cord-024189-t7mbsr25 151 21 headaches headache NNS cord-024189-t7mbsr25 151 22 , , , cord-024189-t7mbsr25 151 23 have have VBP cord-024189-t7mbsr25 151 24 normal normal JJ cord-024189-t7mbsr25 151 25 temporal temporal JJ cord-024189-t7mbsr25 151 26 arteries artery NNS cord-024189-t7mbsr25 151 27 on on IN cord-024189-t7mbsr25 151 28 examination examination NN cord-024189-t7mbsr25 151 29 , , , cord-024189-t7mbsr25 151 30 and and CC cord-024189-t7mbsr25 151 31 almost almost RB cord-024189-t7mbsr25 151 32 50 50 CD cord-024189-t7mbsr25 151 33 % % NN cord-024189-t7mbsr25 151 34 of of IN cord-024189-t7mbsr25 151 35 temporal temporal JJ cord-024189-t7mbsr25 151 36 artery artery NN cord-024189-t7mbsr25 151 37 biopsies biopsy NNS cord-024189-t7mbsr25 151 38 are be VBP cord-024189-t7mbsr25 151 39 negative negative JJ cord-024189-t7mbsr25 151 40 for for IN cord-024189-t7mbsr25 151 41 vasculitis vasculitis NN cord-024189-t7mbsr25 151 42 ( ( -LRB- cord-024189-t7mbsr25 151 43 12 12 CD cord-024189-t7mbsr25 151 44 ) ) -RRB- cord-024189-t7mbsr25 151 45 . . . cord-024189-t7mbsr25 152 1 Aortitis Aortitis NNP cord-024189-t7mbsr25 152 2 in in IN cord-024189-t7mbsr25 152 3 GCA GCA NNP cord-024189-t7mbsr25 152 4 can can MD cord-024189-t7mbsr25 152 5 coexist coexist VB cord-024189-t7mbsr25 152 6 with with IN cord-024189-t7mbsr25 152 7 cranial cranial JJ cord-024189-t7mbsr25 152 8 arteritis arteritis NN cord-024189-t7mbsr25 152 9 . . . cord-024189-t7mbsr25 153 1 Whether whether IN cord-024189-t7mbsr25 153 2 the the DT cord-024189-t7mbsr25 153 3 patient patient NN cord-024189-t7mbsr25 153 4 subset subset VBN cord-024189-t7mbsr25 153 5 with with IN cord-024189-t7mbsr25 153 6 subclavian subclavian JJ cord-024189-t7mbsr25 153 7 - - HYPH cord-024189-t7mbsr25 153 8 axillary axillary JJ cord-024189-t7mbsr25 153 9 GCA GCA NNP cord-024189-t7mbsr25 153 10 is be VBZ cord-024189-t7mbsr25 153 11 distinct distinct JJ cord-024189-t7mbsr25 153 12 from from IN cord-024189-t7mbsr25 153 13 the the DT cord-024189-t7mbsr25 153 14 subset subset NN cord-024189-t7mbsr25 153 15 progressing progress VBG cord-024189-t7mbsr25 153 16 to to IN cord-024189-t7mbsr25 153 17 aortic aortic JJ cord-024189-t7mbsr25 153 18 involvement involvement NN cord-024189-t7mbsr25 153 19 is be VBZ cord-024189-t7mbsr25 153 20 not not RB cord-024189-t7mbsr25 153 21 known know VBN cord-024189-t7mbsr25 153 22 . . . cord-024189-t7mbsr25 154 1 Overall overall RB cord-024189-t7mbsr25 154 2 , , , cord-024189-t7mbsr25 154 3 the the DT cord-024189-t7mbsr25 154 4 risk risk NN cord-024189-t7mbsr25 154 5 of of IN cord-024189-t7mbsr25 154 6 patients patient NNS cord-024189-t7mbsr25 154 7 with with IN cord-024189-t7mbsr25 154 8 GCA GCA NNP cord-024189-t7mbsr25 154 9 to to TO cord-024189-t7mbsr25 154 10 develop develop VB cord-024189-t7mbsr25 154 11 thoracic thoracic JJ cord-024189-t7mbsr25 154 12 aortic aortic JJ cord-024189-t7mbsr25 154 13 aneurysm aneurysm NN cord-024189-t7mbsr25 154 14 is be VBZ cord-024189-t7mbsr25 154 15 increased increase VBN cord-024189-t7mbsr25 154 16 17-fold 17-fold JJ cord-024189-t7mbsr25 154 17 ( ( -LRB- cord-024189-t7mbsr25 154 18 13 13 CD cord-024189-t7mbsr25 154 19 ) ) -RRB- cord-024189-t7mbsr25 154 20 . . . cord-024189-t7mbsr25 155 1 The the DT cord-024189-t7mbsr25 155 2 elastic elastic JJ cord-024189-t7mbsr25 155 3 membranes membrane NNS cord-024189-t7mbsr25 155 4 supporting support VBG cord-024189-t7mbsr25 155 5 the the DT cord-024189-t7mbsr25 155 6 aortic aortic JJ cord-024189-t7mbsr25 155 7 wall wall NN cord-024189-t7mbsr25 155 8 are be VBP cord-024189-t7mbsr25 155 9 destroyed destroy VBN cord-024189-t7mbsr25 155 10 and and CC cord-024189-t7mbsr25 155 11 replaced replace VBN cord-024189-t7mbsr25 155 12 by by IN cord-024189-t7mbsr25 155 13 fi fi NNP cord-024189-t7mbsr25 155 14 brotic brotic JJ cord-024189-t7mbsr25 155 15 tissue tissue NN cord-024189-t7mbsr25 155 16 . . . cord-024189-t7mbsr25 156 1 The the DT cord-024189-t7mbsr25 156 2 resulting result VBG cord-024189-t7mbsr25 156 3 histopathology histopathology NN cord-024189-t7mbsr25 156 4 can can MD cord-024189-t7mbsr25 156 5 be be VB cord-024189-t7mbsr25 156 6 indistinguishable indistinguishable JJ cord-024189-t7mbsr25 156 7 from from IN cord-024189-t7mbsr25 156 8 that that DT cord-024189-t7mbsr25 156 9 of of IN cord-024189-t7mbsr25 156 10 TA TA NNP cord-024189-t7mbsr25 156 11 . . . cord-024189-t7mbsr25 157 1 Most Most JJS cord-024189-t7mbsr25 157 2 cases case NNS cord-024189-t7mbsr25 157 3 of of IN cord-024189-t7mbsr25 157 4 aortitis aortitis NNP cord-024189-t7mbsr25 157 5 have have VBP cord-024189-t7mbsr25 157 6 been be VBN cord-024189-t7mbsr25 157 7 diagnosed diagnose VBN cord-024189-t7mbsr25 157 8 several several JJ cord-024189-t7mbsr25 157 9 years year NNS cord-024189-t7mbsr25 157 10 after after IN cord-024189-t7mbsr25 157 11 the the DT cord-024189-t7mbsr25 157 12 initial initial JJ cord-024189-t7mbsr25 157 13 diagnosis diagnosis NN cord-024189-t7mbsr25 157 14 of of IN cord-024189-t7mbsr25 157 15 GCA GCA NNP cord-024189-t7mbsr25 157 16 , , , cord-024189-t7mbsr25 157 17 raising raise VBG cord-024189-t7mbsr25 157 18 the the DT cord-024189-t7mbsr25 157 19 possibility possibility NN cord-024189-t7mbsr25 157 20 that that IN cord-024189-t7mbsr25 157 21 smoldering smolder VBG cord-024189-t7mbsr25 157 22 aortitis aortitis NN cord-024189-t7mbsr25 157 23 is be VBZ cord-024189-t7mbsr25 157 24 more more RBR cord-024189-t7mbsr25 157 25 common common JJ cord-024189-t7mbsr25 157 26 than than IN cord-024189-t7mbsr25 157 27 previously previously RB cord-024189-t7mbsr25 157 28 expected expect VBN cord-024189-t7mbsr25 157 29 ( ( -LRB- cord-024189-t7mbsr25 157 30 14 14 CD cord-024189-t7mbsr25 157 31 ) ) -RRB- cord-024189-t7mbsr25 157 32 . . . cord-024189-t7mbsr25 158 1 The the DT cord-024189-t7mbsr25 158 2 spectrum spectrum NN cord-024189-t7mbsr25 158 3 of of IN cord-024189-t7mbsr25 158 4 clinical clinical JJ cord-024189-t7mbsr25 158 5 manifestations manifestation NNS cord-024189-t7mbsr25 158 6 ranges range NNS cord-024189-t7mbsr25 158 7 from from IN cord-024189-t7mbsr25 158 8 silent silent JJ cord-024189-t7mbsr25 158 9 aneurysm aneurysm NN cord-024189-t7mbsr25 158 10 to to IN cord-024189-t7mbsr25 158 11 aortic aortic JJ cord-024189-t7mbsr25 158 12 dissection dissection NN cord-024189-t7mbsr25 158 13 and and CC cord-024189-t7mbsr25 158 14 fatal fatal JJ cord-024189-t7mbsr25 158 15 rupture rupture NN cord-024189-t7mbsr25 158 16 . . . cord-024189-t7mbsr25 159 1 In in IN cord-024189-t7mbsr25 159 2 1990 1990 CD cord-024189-t7mbsr25 159 3 , , , cord-024189-t7mbsr25 159 4 the the DT cord-024189-t7mbsr25 159 5 American American NNP cord-024189-t7mbsr25 159 6 College College NNP cord-024189-t7mbsr25 159 7 of of IN cord-024189-t7mbsr25 159 8 Rheumatology Rheumatology NNP cord-024189-t7mbsr25 159 9 ( ( -LRB- cord-024189-t7mbsr25 159 10 ACR ACR NNP cord-024189-t7mbsr25 159 11 ) ) -RRB- cord-024189-t7mbsr25 159 12 formulated formulate VBD cord-024189-t7mbsr25 159 13 classifi classifi NNP cord-024189-t7mbsr25 159 14 cation cation NN cord-024189-t7mbsr25 159 15 criteria criterion NNS cord-024189-t7mbsr25 159 16 for for IN cord-024189-t7mbsr25 159 17 GCA GCA NNP cord-024189-t7mbsr25 159 18 . . . cord-024189-t7mbsr25 160 1 These these DT cord-024189-t7mbsr25 160 2 criteria criterion NNS cord-024189-t7mbsr25 160 3 , , , cord-024189-t7mbsr25 160 4 not not RB cord-024189-t7mbsr25 160 5 intended intend VBN cord-024189-t7mbsr25 160 6 for for IN cord-024189-t7mbsr25 160 7 the the DT cord-024189-t7mbsr25 160 8 purposes purpose NNS cord-024189-t7mbsr25 160 9 of of IN cord-024189-t7mbsr25 160 10 establishing establish VBG cord-024189-t7mbsr25 160 11 a a DT cord-024189-t7mbsr25 160 12 clinical clinical JJ cord-024189-t7mbsr25 160 13 diagnosis diagnosis NN cord-024189-t7mbsr25 160 14 of of IN cord-024189-t7mbsr25 160 15 GCA GCA NNP cord-024189-t7mbsr25 160 16 , , , cord-024189-t7mbsr25 160 17 are be VBP cord-024189-t7mbsr25 160 18 shown show VBN cord-024189-t7mbsr25 160 19 in in IN cord-024189-t7mbsr25 160 20 Appendix Appendix NNP cord-024189-t7mbsr25 160 21 I. I. NNP cord-024189-t7mbsr25 161 1 The the DT cord-024189-t7mbsr25 161 2 diagnosis diagnosis NN cord-024189-t7mbsr25 161 3 of of IN cord-024189-t7mbsr25 161 4 GCA GCA NNP cord-024189-t7mbsr25 161 5 should should MD cord-024189-t7mbsr25 161 6 be be VB cord-024189-t7mbsr25 161 7 considered consider VBN cord-024189-t7mbsr25 161 8 in in IN cord-024189-t7mbsr25 161 9 patients patient NNS cord-024189-t7mbsr25 161 10 aged age VBN cord-024189-t7mbsr25 161 11 50 50 CD cord-024189-t7mbsr25 161 12 years year NNS cord-024189-t7mbsr25 161 13 and and CC cord-024189-t7mbsr25 161 14 older old JJR cord-024189-t7mbsr25 161 15 with with IN cord-024189-t7mbsr25 161 16 recent recent JJ cord-024189-t7mbsr25 161 17 onset onset NN cord-024189-t7mbsr25 161 18 of of IN cord-024189-t7mbsr25 161 19 unexplained unexplained JJ cord-024189-t7mbsr25 161 20 headache headache NN cord-024189-t7mbsr25 161 21 , , , cord-024189-t7mbsr25 161 22 signs sign NNS cord-024189-t7mbsr25 161 23 of of IN cord-024189-t7mbsr25 161 24 tissue tissue NN cord-024189-t7mbsr25 161 25 ischemia ischemia NN cord-024189-t7mbsr25 161 26 in in IN cord-024189-t7mbsr25 161 27 the the DT cord-024189-t7mbsr25 161 28 extracranial extracranial JJ cord-024189-t7mbsr25 161 29 vascular vascular JJ cord-024189-t7mbsr25 161 30 territory territory NN cord-024189-t7mbsr25 161 31 , , , cord-024189-t7mbsr25 161 32 loss loss NN cord-024189-t7mbsr25 161 33 of of IN cord-024189-t7mbsr25 161 34 vision vision NN cord-024189-t7mbsr25 161 35 , , , cord-024189-t7mbsr25 161 36 symptoms symptom NNS cord-024189-t7mbsr25 161 37 of of IN cord-024189-t7mbsr25 161 38 limb limb NN cord-024189-t7mbsr25 161 39 or or CC cord-024189-t7mbsr25 161 40 jaw jaw NN cord-024189-t7mbsr25 161 41 claudication claudication NN cord-024189-t7mbsr25 161 42 , , , cord-024189-t7mbsr25 161 43 or or CC cord-024189-t7mbsr25 161 44 polymyalgia polymyalgia NNP cord-024189-t7mbsr25 161 45 rheumatica rheumatica NNP cord-024189-t7mbsr25 161 46 . . . cord-024189-t7mbsr25 162 1 Laboratory laboratory JJ cord-024189-t7mbsr25 162 2 evidence evidence NN cord-024189-t7mbsr25 162 3 of of IN cord-024189-t7mbsr25 162 4 an an DT cord-024189-t7mbsr25 162 5 acute acute JJ cord-024189-t7mbsr25 162 6 phase phase NN cord-024189-t7mbsr25 162 7 response response NN cord-024189-t7mbsr25 162 8 heightens heighten VBZ cord-024189-t7mbsr25 162 9 concern concern NN cord-024189-t7mbsr25 162 10 about about IN cord-024189-t7mbsr25 162 11 GCA GCA NNP cord-024189-t7mbsr25 162 12 . . . cord-024189-t7mbsr25 163 1 The the DT cord-024189-t7mbsr25 163 2 diagnostic diagnostic JJ cord-024189-t7mbsr25 163 3 procedure procedure NN cord-024189-t7mbsr25 163 4 of of IN cord-024189-t7mbsr25 163 5 choice choice NN cord-024189-t7mbsr25 163 6 is be VBZ cord-024189-t7mbsr25 163 7 the the DT cord-024189-t7mbsr25 163 8 histological histological JJ cord-024189-t7mbsr25 163 9 verifi verifi NN cord-024189-t7mbsr25 163 10 cation cation NN cord-024189-t7mbsr25 163 11 with with IN cord-024189-t7mbsr25 163 12 the the DT cord-024189-t7mbsr25 163 13 superfi superfi NNP cord-024189-t7mbsr25 163 14 cial cial NNP cord-024189-t7mbsr25 163 15 temporal temporal JJ cord-024189-t7mbsr25 163 16 artery artery NN cord-024189-t7mbsr25 163 17 . . . cord-024189-t7mbsr25 164 1 In in IN cord-024189-t7mbsr25 164 2 a a DT cord-024189-t7mbsr25 164 3 recent recent JJ cord-024189-t7mbsr25 164 4 meta meta JJ cord-024189-t7mbsr25 164 5 - - HYPH cord-024189-t7mbsr25 164 6 analysis analysis NN cord-024189-t7mbsr25 164 7 , , , cord-024189-t7mbsr25 164 8 positive positive JJ cord-024189-t7mbsr25 164 9 clinical clinical JJ cord-024189-t7mbsr25 164 10 predictors predictor NNS cord-024189-t7mbsr25 164 11 of of IN cord-024189-t7mbsr25 164 12 a a DT cord-024189-t7mbsr25 164 13 positive positive JJ cord-024189-t7mbsr25 164 14 biopsy biopsy NN cord-024189-t7mbsr25 164 15 were be VBD cord-024189-t7mbsr25 164 16 jaw jaw NN cord-024189-t7mbsr25 164 17 claudication claudication NN cord-024189-t7mbsr25 164 18 , , , cord-024189-t7mbsr25 164 19 diplopia diplopia NN cord-024189-t7mbsr25 164 20 , , , cord-024189-t7mbsr25 164 21 and and CC cord-024189-t7mbsr25 164 22 abnormalities abnormality NNS cord-024189-t7mbsr25 164 23 of of IN cord-024189-t7mbsr25 164 24 the the DT cord-024189-t7mbsr25 164 25 temporal temporal JJ cord-024189-t7mbsr25 164 26 artery artery NN cord-024189-t7mbsr25 164 27 biopsy biopsy NN cord-024189-t7mbsr25 164 28 on on IN cord-024189-t7mbsr25 164 29 physical physical JJ cord-024189-t7mbsr25 164 30 examination examination NN cord-024189-t7mbsr25 164 31 ( ( -LRB- cord-024189-t7mbsr25 164 32 15 15 CD cord-024189-t7mbsr25 164 33 ) ) -RRB- cord-024189-t7mbsr25 164 34 . . . cord-024189-t7mbsr25 165 1 All all DT cord-024189-t7mbsr25 165 2 other other JJ cord-024189-t7mbsr25 165 3 symptoms symptom NNS cord-024189-t7mbsr25 165 4 , , , cord-024189-t7mbsr25 165 5 including include VBG cord-024189-t7mbsr25 165 6 vision vision NN cord-024189-t7mbsr25 165 7 loss loss NN cord-024189-t7mbsr25 165 8 , , , cord-024189-t7mbsr25 165 9 elevated elevated JJ cord-024189-t7mbsr25 165 10 sedimentation sedimentation NN cord-024189-t7mbsr25 165 11 rate rate NN cord-024189-t7mbsr25 165 12 , , , cord-024189-t7mbsr25 165 13 headaches headache NNS cord-024189-t7mbsr25 165 14 , , , cord-024189-t7mbsr25 165 15 and and CC cord-024189-t7mbsr25 165 16 constitutional constitutional JJ cord-024189-t7mbsr25 165 17 symptoms symptom NNS cord-024189-t7mbsr25 165 18 , , , cord-024189-t7mbsr25 165 19 were be VBD cord-024189-t7mbsr25 165 20 not not RB cord-024189-t7mbsr25 165 21 particularly particularly RB cord-024189-t7mbsr25 165 22 helpful helpful JJ cord-024189-t7mbsr25 165 23 in in IN cord-024189-t7mbsr25 165 24 predicting predict VBG cord-024189-t7mbsr25 165 25 the the DT cord-024189-t7mbsr25 165 26 results result NNS cord-024189-t7mbsr25 165 27 of of IN cord-024189-t7mbsr25 165 28 temporal temporal JJ cord-024189-t7mbsr25 165 29 artery artery NN cord-024189-t7mbsr25 165 30 biopsies biopsy NNS cord-024189-t7mbsr25 165 31 ( ( -LRB- cord-024189-t7mbsr25 165 32 i.e. i.e. FW cord-024189-t7mbsr25 165 33 , , , cord-024189-t7mbsr25 165 34 in in IN cord-024189-t7mbsr25 165 35 diagnosing diagnose VBG cord-024189-t7mbsr25 165 36 GCA GCA NNP cord-024189-t7mbsr25 165 37 ) ) -RRB- cord-024189-t7mbsr25 165 38 . . . cord-024189-t7mbsr25 166 1 The the DT cord-024189-t7mbsr25 166 2 presence presence NN cord-024189-t7mbsr25 166 3 of of IN cord-024189-t7mbsr25 166 4 synovitis synovitis NNP cord-024189-t7mbsr25 166 5 was be VBD cord-024189-t7mbsr25 166 6 a a DT cord-024189-t7mbsr25 166 7 negative negative JJ cord-024189-t7mbsr25 166 8 predictor predictor NN cord-024189-t7mbsr25 166 9 of of IN cord-024189-t7mbsr25 166 10 GCA GCA NNP cord-024189-t7mbsr25 166 11 , , , cord-024189-t7mbsr25 166 12 indicative indicative JJ cord-024189-t7mbsr25 166 13 of of IN cord-024189-t7mbsr25 166 14 the the DT cord-024189-t7mbsr25 166 15 fact fact NN cord-024189-t7mbsr25 166 16 that that IN cord-024189-t7mbsr25 166 17 most most JJS cord-024189-t7mbsr25 166 18 patients patient NNS cord-024189-t7mbsr25 166 19 with with IN cord-024189-t7mbsr25 166 20 true true JJ cord-024189-t7mbsr25 166 21 arthritis arthritis NN cord-024189-t7mbsr25 166 22 have have VBP cord-024189-t7mbsr25 166 23 another another DT cord-024189-t7mbsr25 166 24 diagnosis diagnosis NN cord-024189-t7mbsr25 166 25 , , , cord-024189-t7mbsr25 166 26 such such JJ cord-024189-t7mbsr25 166 27 as as IN cord-024189-t7mbsr25 166 28 rheumatoid rheumatoid JJ cord-024189-t7mbsr25 166 29 arthritis arthritis NN cord-024189-t7mbsr25 166 30 . . . cord-024189-t7mbsr25 167 1 Even even RB cord-024189-t7mbsr25 167 2 the the DT cord-024189-t7mbsr25 167 3 most most RBS cord-024189-t7mbsr25 167 4 specifi specifi JJ cord-024189-t7mbsr25 167 5 c c NN cord-024189-t7mbsr25 167 6 fi fi NNP cord-024189-t7mbsr25 167 7 ndings nding NNS cord-024189-t7mbsr25 167 8 for for IN cord-024189-t7mbsr25 167 9 history history NN cord-024189-t7mbsr25 167 10 , , , cord-024189-t7mbsr25 167 11 physical physical JJ cord-024189-t7mbsr25 167 12 examination examination NN cord-024189-t7mbsr25 167 13 , , , cord-024189-t7mbsr25 167 14 and and CC cord-024189-t7mbsr25 167 15 routine routine JJ cord-024189-t7mbsr25 167 16 laboratory laboratory NN cord-024189-t7mbsr25 167 17 testing testing NN cord-024189-t7mbsr25 167 18 have have VBP cord-024189-t7mbsr25 167 19 sensitivities sensitivity NNS cord-024189-t7mbsr25 167 20 of of IN cord-024189-t7mbsr25 167 21 only only RB cord-024189-t7mbsr25 167 22 ( ( -LRB- cord-024189-t7mbsr25 167 23 at at IN cord-024189-t7mbsr25 167 24 best good JJS cord-024189-t7mbsr25 167 25 ) ) -RRB- cord-024189-t7mbsr25 167 26 50 50 CD cord-024189-t7mbsr25 167 27 % % NN cord-024189-t7mbsr25 167 28 . . . cord-024189-t7mbsr25 168 1 In in IN cord-024189-t7mbsr25 168 2 view view NN cord-024189-t7mbsr25 168 3 of of IN cord-024189-t7mbsr25 168 4 the the DT cord-024189-t7mbsr25 168 5 fact fact NN cord-024189-t7mbsr25 168 6 that that IN cord-024189-t7mbsr25 168 7 rendering render VBG cord-024189-t7mbsr25 168 8 the the DT cord-024189-t7mbsr25 168 9 diagnosis diagnosis NN cord-024189-t7mbsr25 168 10 of of IN cord-024189-t7mbsr25 168 11 GCA GCA NNP cord-024189-t7mbsr25 168 12 commits commit VBZ cord-024189-t7mbsr25 168 13 a a DT cord-024189-t7mbsr25 168 14 patient patient NN cord-024189-t7mbsr25 168 15 to to IN cord-024189-t7mbsr25 168 16 long long JJ cord-024189-t7mbsr25 168 17 - - HYPH cord-024189-t7mbsr25 168 18 term term NN cord-024189-t7mbsr25 168 19 course course NN cord-024189-t7mbsr25 168 20 of of IN cord-024189-t7mbsr25 168 21 glucocorticoid glucocorticoid NN cord-024189-t7mbsr25 168 22 therapy therapy NN cord-024189-t7mbsr25 168 23 , , , cord-024189-t7mbsr25 168 24 confi confi NNP cord-024189-t7mbsr25 168 25 rmation rmation NN cord-024189-t7mbsr25 168 26 of of IN cord-024189-t7mbsr25 168 27 the the DT cord-024189-t7mbsr25 168 28 diagnosis diagnosis NN cord-024189-t7mbsr25 168 29 by by IN cord-024189-t7mbsr25 168 30 temporal temporal JJ cord-024189-t7mbsr25 168 31 artery artery NN cord-024189-t7mbsr25 168 32 biopsy biopsy NN cord-024189-t7mbsr25 168 33 is be VBZ cord-024189-t7mbsr25 168 34 essential essential JJ cord-024189-t7mbsr25 168 35 whenever whenever WRB cord-024189-t7mbsr25 168 36 possible possible JJ cord-024189-t7mbsr25 168 37 . . . cord-024189-t7mbsr25 169 1 True true JJ cord-024189-t7mbsr25 169 2 negative negative JJ cord-024189-t7mbsr25 169 3 results result NNS cord-024189-t7mbsr25 169 4 are be VBP cord-024189-t7mbsr25 169 5 expected expect VBN cord-024189-t7mbsr25 169 6 in in IN cord-024189-t7mbsr25 169 7 more more JJR cord-024189-t7mbsr25 169 8 than than IN cord-024189-t7mbsr25 169 9 50 50 CD cord-024189-t7mbsr25 169 10 % % NN cord-024189-t7mbsr25 169 11 to to TO cord-024189-t7mbsr25 169 12 70 70 CD cord-024189-t7mbsr25 169 13 % % NN cord-024189-t7mbsr25 169 14 of of IN cord-024189-t7mbsr25 169 15 all all DT cord-024189-t7mbsr25 169 16 patients patient NNS cord-024189-t7mbsr25 169 17 undergoing undergo VBG cord-024189-t7mbsr25 169 18 biopsies biopsy NNS cord-024189-t7mbsr25 169 19 at at IN cord-024189-t7mbsr25 169 20 most most JJS cord-024189-t7mbsr25 169 21 institutions institution NNS cord-024189-t7mbsr25 169 22 . . . cord-024189-t7mbsr25 170 1 False false JJ cord-024189-t7mbsr25 170 2 - - HYPH cord-024189-t7mbsr25 170 3 negative negative JJ cord-024189-t7mbsr25 170 4 biopsies biopsy NNS cord-024189-t7mbsr25 170 5 , , , cord-024189-t7mbsr25 170 6 which which WDT cord-024189-t7mbsr25 170 7 occur occur VBP cord-024189-t7mbsr25 170 8 as as RB cord-024189-t7mbsr25 170 9 frequently frequently RB cord-024189-t7mbsr25 170 10 as as IN cord-024189-t7mbsr25 170 11 10 10 CD cord-024189-t7mbsr25 170 12 % % NN cord-024189-t7mbsr25 170 13 of of IN cord-024189-t7mbsr25 170 14 the the DT cord-024189-t7mbsr25 170 15 time time NN cord-024189-t7mbsr25 170 16 , , , cord-024189-t7mbsr25 170 17 can can MD cord-024189-t7mbsr25 170 18 be be VB cord-024189-t7mbsr25 170 19 minimized minimize VBN cord-024189-t7mbsr25 170 20 by by IN cord-024189-t7mbsr25 170 21 taking take VBG cord-024189-t7mbsr25 170 22 a a DT cord-024189-t7mbsr25 170 23 suffi suffi NNP cord-024189-t7mbsr25 170 24 cient cient NN cord-024189-t7mbsr25 170 25 length length NN cord-024189-t7mbsr25 170 26 of of IN cord-024189-t7mbsr25 170 27 biopsy biopsy NN cord-024189-t7mbsr25 170 28 , , , cord-024189-t7mbsr25 170 29 by by IN cord-024189-t7mbsr25 170 30 examining examine VBG cord-024189-t7mbsr25 170 31 serial serial JJ cord-024189-t7mbsr25 170 32 sections section NNS cord-024189-t7mbsr25 170 33 , , , cord-024189-t7mbsr25 170 34 and and CC cord-024189-t7mbsr25 170 35 by by IN cord-024189-t7mbsr25 170 36 removing remove VBG cord-024189-t7mbsr25 170 37 the the DT cord-024189-t7mbsr25 170 38 contralateral contralateral JJ cord-024189-t7mbsr25 170 39 temporal temporal JJ cord-024189-t7mbsr25 170 40 artery artery NN cord-024189-t7mbsr25 170 41 when when WRB cord-024189-t7mbsr25 170 42 the the DT cord-024189-t7mbsr25 170 43 fi fi NN cord-024189-t7mbsr25 170 44 rst rst NNP cord-024189-t7mbsr25 170 45 biopsy biopsy NN cord-024189-t7mbsr25 170 46 is be VBZ cord-024189-t7mbsr25 170 47 free free JJ cord-024189-t7mbsr25 170 48 of of IN cord-024189-t7mbsr25 170 49 arteritis arteritis NN cord-024189-t7mbsr25 170 50 . . . cord-024189-t7mbsr25 171 1 Short short JJ cord-024189-t7mbsr25 171 2 - - HYPH cord-024189-t7mbsr25 171 3 term term NN cord-024189-t7mbsr25 171 4 glucocorticoid glucocorticoid NN cord-024189-t7mbsr25 171 5 treatment treatment NN cord-024189-t7mbsr25 171 6 ( ( -LRB- cord-024189-t7mbsr25 171 7 up up IN cord-024189-t7mbsr25 171 8 to to TO cord-024189-t7mbsr25 171 9 2 2 CD cord-024189-t7mbsr25 171 10 weeks week NNS cord-024189-t7mbsr25 171 11 , , , cord-024189-t7mbsr25 171 12 or or CC cord-024189-t7mbsr25 171 13 even even RB cord-024189-t7mbsr25 171 14 signifi signifi NNP cord-024189-t7mbsr25 171 15 cantly cantly RB cord-024189-t7mbsr25 171 16 longer long RBR cord-024189-t7mbsr25 171 17 ) ) -RRB- cord-024189-t7mbsr25 171 18 is be VBZ cord-024189-t7mbsr25 171 19 unlikely unlikely JJ cord-024189-t7mbsr25 171 20 to to TO cord-024189-t7mbsr25 171 21 interfere interfere VB cord-024189-t7mbsr25 171 22 with with IN cord-024189-t7mbsr25 171 23 the the DT cord-024189-t7mbsr25 171 24 results result NNS cord-024189-t7mbsr25 171 25 of of IN cord-024189-t7mbsr25 171 26 a a DT cord-024189-t7mbsr25 171 27 temporal temporal JJ cord-024189-t7mbsr25 171 28 artery artery NN cord-024189-t7mbsr25 171 29 biopsy biopsy NN cord-024189-t7mbsr25 171 30 . . . cord-024189-t7mbsr25 172 1 Prednisone Prednisone NNP cord-024189-t7mbsr25 172 2 should should MD cord-024189-t7mbsr25 172 3 therefore therefore RB cord-024189-t7mbsr25 172 4 not not RB cord-024189-t7mbsr25 172 5 be be VB cord-024189-t7mbsr25 172 6 withheld withhold VBN cord-024189-t7mbsr25 172 7 if if IN cord-024189-t7mbsr25 172 8 a a DT cord-024189-t7mbsr25 172 9 biopsy biopsy NN cord-024189-t7mbsr25 172 10 can can MD cord-024189-t7mbsr25 172 11 not not RB cord-024189-t7mbsr25 172 12 be be VB cord-024189-t7mbsr25 172 13 performed perform VBN cord-024189-t7mbsr25 172 14 immediately immediately RB cord-024189-t7mbsr25 172 15 . . . cord-024189-t7mbsr25 173 1 A a DT cord-024189-t7mbsr25 173 2 pathognomic pathognomic JJ cord-024189-t7mbsr25 173 3 laboratory laboratory NN cord-024189-t7mbsr25 173 4 test test NN cord-024189-t7mbsr25 173 5 for for IN cord-024189-t7mbsr25 173 6 GCA GCA NNP cord-024189-t7mbsr25 173 7 does do VBZ cord-024189-t7mbsr25 173 8 not not RB cord-024189-t7mbsr25 173 9 exist exist VB cord-024189-t7mbsr25 173 10 . . . cord-024189-t7mbsr25 174 1 Specifi Specifi NNP cord-024189-t7mbsr25 174 2 c c NN cord-024189-t7mbsr25 174 3 autoantibodies autoantibody NNS cord-024189-t7mbsr25 174 4 have have VBP cord-024189-t7mbsr25 174 5 not not RB cord-024189-t7mbsr25 174 6 been be VBN cord-024189-t7mbsr25 174 7 identifi identifi VBN cord-024189-t7mbsr25 174 8 ed ed NN cord-024189-t7mbsr25 174 9 . . . cord-024189-t7mbsr25 175 1 Highly highly RB cord-024189-t7mbsr25 175 2 elevated elevated JJ cord-024189-t7mbsr25 175 3 acute acute JJ cord-024189-t7mbsr25 175 4 phase phase NN cord-024189-t7mbsr25 175 5 responses response NNS cord-024189-t7mbsr25 175 6 are be VBP cord-024189-t7mbsr25 175 7 typical typical JJ cord-024189-t7mbsr25 175 8 for for IN cord-024189-t7mbsr25 175 9 GCA GCA NNP cord-024189-t7mbsr25 175 10 but but CC cord-024189-t7mbsr25 175 11 are be VBP cord-024189-t7mbsr25 175 12 not not RB cord-024189-t7mbsr25 175 13 present present JJ cord-024189-t7mbsr25 175 14 in in IN cord-024189-t7mbsr25 175 15 all all DT cord-024189-t7mbsr25 175 16 patients patient NNS cord-024189-t7mbsr25 175 17 . . . cord-024189-t7mbsr25 176 1 Although although IN cord-024189-t7mbsr25 176 2 a a DT cord-024189-t7mbsr25 176 3 high high JJ cord-024189-t7mbsr25 176 4 erythrocyte erythrocyte NN cord-024189-t7mbsr25 176 5 sedimentation sedimentation NN cord-024189-t7mbsr25 176 6 rate rate NN cord-024189-t7mbsr25 176 7 ( ( -LRB- cord-024189-t7mbsr25 176 8 ESR ESR NNP cord-024189-t7mbsr25 176 9 ) ) -RRB- cord-024189-t7mbsr25 176 10 is be VBZ cord-024189-t7mbsr25 176 11 usually usually RB cord-024189-t7mbsr25 176 12 considered consider VBN cord-024189-t7mbsr25 176 13 a a DT cord-024189-t7mbsr25 176 14 hallmark hallmark NN cord-024189-t7mbsr25 176 15 of of IN cord-024189-t7mbsr25 176 16 GCA GCA NNP cord-024189-t7mbsr25 176 17 , , , cord-024189-t7mbsr25 176 18 in in IN cord-024189-t7mbsr25 176 19 a a DT cord-024189-t7mbsr25 176 20 recent recent JJ cord-024189-t7mbsr25 176 21 study study NN cord-024189-t7mbsr25 176 22 25 25 CD cord-024189-t7mbsr25 176 23 % % NN cord-024189-t7mbsr25 176 24 of of IN cord-024189-t7mbsr25 176 25 all all DT cord-024189-t7mbsr25 176 26 patients patient NNS cord-024189-t7mbsr25 176 27 with with IN cord-024189-t7mbsr25 176 28 positive positive JJ cord-024189-t7mbsr25 176 29 temporal temporal JJ cord-024189-t7mbsr25 176 30 artery artery NN cord-024189-t7mbsr25 176 31 biopsies biopsy NNS cord-024189-t7mbsr25 176 32 had have VBD cord-024189-t7mbsr25 176 33 normal normal JJ cord-024189-t7mbsr25 176 34 ESRs esr NNS cord-024189-t7mbsr25 176 35 before before IN cord-024189-t7mbsr25 176 36 the the DT cord-024189-t7mbsr25 176 37 initiation initiation NN cord-024189-t7mbsr25 176 38 of of IN cord-024189-t7mbsr25 176 39 glucocorticoid glucocorticoid NN cord-024189-t7mbsr25 176 40 therapy therapy NN cord-024189-t7mbsr25 176 41 ( ( -LRB- cord-024189-t7mbsr25 176 42 16 16 CD cord-024189-t7mbsr25 176 43 ) ) -RRB- cord-024189-t7mbsr25 176 44 . . . cord-024189-t7mbsr25 177 1 Other other JJ cord-024189-t7mbsr25 177 2 markers marker NNS cord-024189-t7mbsr25 177 3 of of IN cord-024189-t7mbsr25 177 4 acute acute JJ cord-024189-t7mbsr25 177 5 phase phase NN cord-024189-t7mbsr25 177 6 response response NN cord-024189-t7mbsr25 177 7 , , , cord-024189-t7mbsr25 177 8 particularly particularly RB cord-024189-t7mbsr25 177 9 Creactive creactive JJ cord-024189-t7mbsr25 177 10 protein protein NN cord-024189-t7mbsr25 177 11 ( ( -LRB- cord-024189-t7mbsr25 177 12 CRP CRP NNP cord-024189-t7mbsr25 177 13 ) ) -RRB- cord-024189-t7mbsr25 177 14 , , , cord-024189-t7mbsr25 177 15 may may MD cord-024189-t7mbsr25 177 16 be be VB cord-024189-t7mbsr25 177 17 more more RBR cord-024189-t7mbsr25 177 18 sensitive sensitive JJ cord-024189-t7mbsr25 177 19 than than IN cord-024189-t7mbsr25 177 20 ESR ESR NNP cord-024189-t7mbsr25 177 21 in in IN cord-024189-t7mbsr25 177 22 some some DT cord-024189-t7mbsr25 177 23 patients patient NNS cord-024189-t7mbsr25 177 24 , , , cord-024189-t7mbsr25 177 25 but but CC cord-024189-t7mbsr25 177 26 studies study NNS cord-024189-t7mbsr25 177 27 have have VBP cord-024189-t7mbsr25 177 28 not not RB cord-024189-t7mbsr25 177 29 demonstrated demonstrate VBN cord-024189-t7mbsr25 177 30 this this DT cord-024189-t7mbsr25 177 31 consistently consistently RB cord-024189-t7mbsr25 177 32 . . . cord-024189-t7mbsr25 178 1 Some some DT cord-024189-t7mbsr25 178 2 evidence evidence NN cord-024189-t7mbsr25 178 3 indicates indicate VBZ cord-024189-t7mbsr25 178 4 that that IN cord-024189-t7mbsr25 178 5 the the DT cord-024189-t7mbsr25 178 6 most most RBS cord-024189-t7mbsr25 178 7 sensitive sensitive JJ cord-024189-t7mbsr25 178 8 serum serum NN cord-024189-t7mbsr25 178 9 marker marker NN cord-024189-t7mbsr25 178 10 for for IN cord-024189-t7mbsr25 178 11 ongoing ongoing JJ cord-024189-t7mbsr25 178 12 systemic systemic JJ cord-024189-t7mbsr25 178 13 infl infl NN cord-024189-t7mbsr25 178 14 ammation ammation NN cord-024189-t7mbsr25 178 15 in in IN cord-024189-t7mbsr25 178 16 GCA GCA NNP cord-024189-t7mbsr25 178 17 ( ( -LRB- cord-024189-t7mbsr25 178 18 both both CC cord-024189-t7mbsr25 178 19 before before IN cord-024189-t7mbsr25 178 20 and and CC cord-024189-t7mbsr25 178 21 after after IN cord-024189-t7mbsr25 178 22 glucocorticoid glucocorticoid NN cord-024189-t7mbsr25 178 23 therapy therapy NN cord-024189-t7mbsr25 178 24 ) ) -RRB- cord-024189-t7mbsr25 178 25 is be VBZ cord-024189-t7mbsr25 178 26 IL-6 IL-6 NNP cord-024189-t7mbsr25 178 27 . . . cord-024189-t7mbsr25 178 28 IL-6 IL-6 NNP cord-024189-t7mbsr25 178 29 , , , cord-024189-t7mbsr25 178 30 a a DT cord-024189-t7mbsr25 178 31 strong strong JJ cord-024189-t7mbsr25 178 32 inducer inducer NN cord-024189-t7mbsr25 178 33 of of IN cord-024189-t7mbsr25 178 34 acute acute JJ cord-024189-t7mbsr25 178 35 phase phase NN cord-024189-t7mbsr25 178 36 reactants reactant NNS cord-024189-t7mbsr25 178 37 , , , cord-024189-t7mbsr25 178 38 probably probably RB cord-024189-t7mbsr25 178 39 functions function VBZ cord-024189-t7mbsr25 178 40 upstream upstream RB cord-024189-t7mbsr25 178 41 in in IN cord-024189-t7mbsr25 178 42 the the DT cord-024189-t7mbsr25 178 43 disease disease NN cord-024189-t7mbsr25 178 44 process process NN cord-024189-t7mbsr25 178 45 . . . cord-024189-t7mbsr25 179 1 Unfortunately unfortunately RB cord-024189-t7mbsr25 179 2 , , , cord-024189-t7mbsr25 179 3 reliable reliable JJ cord-024189-t7mbsr25 179 4 IL-6 IL-6 NNP cord-024189-t7mbsr25 179 5 measurements measurement NNS cord-024189-t7mbsr25 179 6 are be VBP cord-024189-t7mbsr25 179 7 not not RB cord-024189-t7mbsr25 179 8 widely widely RB cord-024189-t7mbsr25 179 9 available available JJ cord-024189-t7mbsr25 179 10 , , , cord-024189-t7mbsr25 179 11 and and CC cord-024189-t7mbsr25 179 12 knowledge knowledge NN cord-024189-t7mbsr25 179 13 about about IN cord-024189-t7mbsr25 179 14 how how WRB cord-024189-t7mbsr25 179 15 ( ( -LRB- cord-024189-t7mbsr25 179 16 or or CC cord-024189-t7mbsr25 179 17 if if IN cord-024189-t7mbsr25 179 18 ) ) -RRB- cord-024189-t7mbsr25 179 19 to to TO cord-024189-t7mbsr25 179 20 adjust adjust VB cord-024189-t7mbsr25 179 21 therapy therapy NN cord-024189-t7mbsr25 179 22 in in IN cord-024189-t7mbsr25 179 23 the the DT cord-024189-t7mbsr25 179 24 context context NN cord-024189-t7mbsr25 179 25 of of IN cord-024189-t7mbsr25 179 26 changing change VBG cord-024189-t7mbsr25 179 27 IL-6 IL-6 NNP cord-024189-t7mbsr25 179 28 levels level NNS cord-024189-t7mbsr25 179 29 remains remain VBZ cord-024189-t7mbsr25 179 30 incomplete incomplete JJ cord-024189-t7mbsr25 179 31 . . . cord-024189-t7mbsr25 180 1 There there EX cord-024189-t7mbsr25 180 2 is be VBZ cord-024189-t7mbsr25 180 3 currently currently RB cord-024189-t7mbsr25 180 4 no no DT cord-024189-t7mbsr25 180 5 evidence evidence NN cord-024189-t7mbsr25 180 6 that that IN cord-024189-t7mbsr25 180 7 treatment treatment NN cord-024189-t7mbsr25 180 8 decisions decision NNS cord-024189-t7mbsr25 180 9 should should MD cord-024189-t7mbsr25 180 10 be be VB cord-024189-t7mbsr25 180 11 predicated predicate VBN cord-024189-t7mbsr25 180 12 upon upon IN cord-024189-t7mbsr25 180 13 the the DT cord-024189-t7mbsr25 180 14 results result NNS cord-024189-t7mbsr25 180 15 of of IN cord-024189-t7mbsr25 180 16 laboratory laboratory NN cord-024189-t7mbsr25 180 17 tests test NNS cord-024189-t7mbsr25 180 18 - - : cord-024189-t7mbsr25 180 19 ESR ESR NNP cord-024189-t7mbsr25 180 20 , , , cord-024189-t7mbsr25 180 21 CRP CRP NNP cord-024189-t7mbsr25 180 22 , , , cord-024189-t7mbsr25 180 23 or or CC cord-024189-t7mbsr25 180 24 IL-6-in IL-6-in MD cord-024189-t7mbsr25 180 25 the the DT cord-024189-t7mbsr25 180 26 absence absence NN cord-024189-t7mbsr25 180 27 of of IN cord-024189-t7mbsr25 180 28 clinical clinical JJ cord-024189-t7mbsr25 180 29 symptoms symptom NNS cord-024189-t7mbsr25 180 30 . . . cord-024189-t7mbsr25 181 1 Other other JJ cord-024189-t7mbsr25 181 2 laboratory laboratory NN cord-024189-t7mbsr25 181 3 abnormalities abnormality NNS cord-024189-t7mbsr25 181 4 in in IN cord-024189-t7mbsr25 181 5 GCA GCA NNP cord-024189-t7mbsr25 181 6 include include VBP cord-024189-t7mbsr25 181 7 mild mild JJ cord-024189-t7mbsr25 181 8 - - HYPH cord-024189-t7mbsr25 181 9 to to IN cord-024189-t7mbsr25 181 10 - - HYPH cord-024189-t7mbsr25 181 11 moderate moderate JJ cord-024189-t7mbsr25 181 12 normochromic normochromic JJ cord-024189-t7mbsr25 181 13 or or CC cord-024189-t7mbsr25 181 14 hypochromic hypochromic JJ cord-024189-t7mbsr25 181 15 anemia anemia NN cord-024189-t7mbsr25 181 16 . . . cord-024189-t7mbsr25 182 1 Elevated elevated JJ cord-024189-t7mbsr25 182 2 platelet platelet NN cord-024189-t7mbsr25 182 3 counts count NNS cord-024189-t7mbsr25 182 4 are be VBP cord-024189-t7mbsr25 182 5 common common JJ cord-024189-t7mbsr25 182 6 . . . cord-024189-t7mbsr25 183 1 Liver liver NN cord-024189-t7mbsr25 183 2 function function NN cord-024189-t7mbsr25 183 3 tests test NNS cord-024189-t7mbsr25 183 4 , , , cord-024189-t7mbsr25 183 5 particularly particularly RB cord-024189-t7mbsr25 183 6 alkaline alkaline JJ cord-024189-t7mbsr25 183 7 phosphatase phosphatase NN cord-024189-t7mbsr25 183 8 , , , cord-024189-t7mbsr25 183 9 can can MD cord-024189-t7mbsr25 183 10 be be VB cord-024189-t7mbsr25 183 11 abnormal abnormal JJ cord-024189-t7mbsr25 183 12 . . . cord-024189-t7mbsr25 184 1 Precise precise JJ cord-024189-t7mbsr25 184 2 mapping mapping NN cord-024189-t7mbsr25 184 3 of of IN cord-024189-t7mbsr25 184 4 the the DT cord-024189-t7mbsr25 184 5 vaso vaso NN cord-024189-t7mbsr25 184 6 - - HYPH cord-024189-t7mbsr25 184 7 occlusive occlusive JJ cord-024189-t7mbsr25 184 8 process process NN cord-024189-t7mbsr25 184 9 still still RB cord-024189-t7mbsr25 184 10 requires require VBZ cord-024189-t7mbsr25 184 11 angiography angiography NN cord-024189-t7mbsr25 184 12 . . . cord-024189-t7mbsr25 185 1 Angiography angiography NN cord-024189-t7mbsr25 185 2 is be VBZ cord-024189-t7mbsr25 185 3 also also RB cord-024189-t7mbsr25 185 4 essential essential JJ cord-024189-t7mbsr25 185 5 for for IN cord-024189-t7mbsr25 185 6 patients patient NNS cord-024189-t7mbsr25 185 7 with with IN cord-024189-t7mbsr25 185 8 signifi signifi NNP cord-024189-t7mbsr25 185 9 ca can MD cord-024189-t7mbsr25 185 10 nt not RB cord-024189-t7mbsr25 185 11 stenoses stenosis NNS cord-024189-t7mbsr25 185 12 in in IN cord-024189-t7mbsr25 185 13 vessels vessel NNS cord-024189-t7mbsr25 185 14 to to IN cord-024189-t7mbsr25 185 15 all all DT cord-024189-t7mbsr25 185 16 four four CD cord-024189-t7mbsr25 185 17 extremities extremity NNS cord-024189-t7mbsr25 185 18 , , , cord-024189-t7mbsr25 185 19 for for IN cord-024189-t7mbsr25 185 20 the the DT cord-024189-t7mbsr25 185 21 purpose purpose NN cord-024189-t7mbsr25 185 22 of of IN cord-024189-t7mbsr25 185 23 measuring measure VBG cord-024189-t7mbsr25 185 24 central central JJ cord-024189-t7mbsr25 185 25 aortic aortic JJ cord-024189-t7mbsr25 185 26 pressure pressure NN cord-024189-t7mbsr25 185 27 directly directly RB cord-024189-t7mbsr25 185 28 . . . cord-024189-t7mbsr25 186 1 Alternatives alternative NNS cord-024189-t7mbsr25 186 2 to to IN cord-024189-t7mbsr25 186 3 conventional conventional JJ cord-024189-t7mbsr25 186 4 angiography angiography NN cord-024189-t7mbsr25 186 5 , , , cord-024189-t7mbsr25 186 6 however however RB cord-024189-t7mbsr25 186 7 , , , cord-024189-t7mbsr25 186 8 have have VBP cord-024189-t7mbsr25 186 9 made make VBN cord-024189-t7mbsr25 186 10 great great JJ cord-024189-t7mbsr25 186 11 strides stride NNS cord-024189-t7mbsr25 186 12 in in IN cord-024189-t7mbsr25 186 13 recent recent JJ cord-024189-t7mbsr25 186 14 years year NNS cord-024189-t7mbsr25 186 15 ( ( -LRB- cord-024189-t7mbsr25 186 16 17 17 CD cord-024189-t7mbsr25 186 17 ) ) -RRB- cord-024189-t7mbsr25 186 18 . . . cord-024189-t7mbsr25 187 1 Magnetic magnetic JJ cord-024189-t7mbsr25 187 2 resonance resonance NN cord-024189-t7mbsr25 187 3 angiography angiography NN cord-024189-t7mbsr25 187 4 ( ( -LRB- cord-024189-t7mbsr25 187 5 MRA MRA NNP cord-024189-t7mbsr25 187 6 ) ) -RRB- cord-024189-t7mbsr25 187 7 permits permit VBZ cord-024189-t7mbsr25 187 8 evaluation evaluation NN cord-024189-t7mbsr25 187 9 of of IN cord-024189-t7mbsr25 187 10 vessel vessel NN cord-024189-t7mbsr25 187 11 wall wall NN cord-024189-t7mbsr25 187 12 thickness thickness NN cord-024189-t7mbsr25 187 13 and and CC cord-024189-t7mbsr25 187 14 perivascular perivascular JJ cord-024189-t7mbsr25 187 15 edema edema NN cord-024189-t7mbsr25 187 16 - - HYPH cord-024189-t7mbsr25 187 17 signifi signifi NNP cord-024189-t7mbsr25 187 18 ca can MD cord-024189-t7mbsr25 187 19 nt not RB cord-024189-t7mbsr25 187 20 advantages advantage NNS cord-024189-t7mbsr25 187 21 over over IN cord-024189-t7mbsr25 187 22 conventional conventional JJ cord-024189-t7mbsr25 187 23 angiograms angiogram NNS cord-024189-t7mbsr25 187 24 , , , cord-024189-t7mbsr25 187 25 which which WDT cord-024189-t7mbsr25 187 26 evaluate evaluate VBP cord-024189-t7mbsr25 187 27 only only RB cord-024189-t7mbsr25 187 28 the the DT cord-024189-t7mbsr25 187 29 vascular vascular JJ cord-024189-t7mbsr25 187 30 lumen lumen NN cord-024189-t7mbsr25 187 31 . . . cord-024189-t7mbsr25 188 1 In in IN cord-024189-t7mbsr25 188 2 the the DT cord-024189-t7mbsr25 188 3 proper proper JJ cord-024189-t7mbsr25 188 4 clinical clinical JJ cord-024189-t7mbsr25 188 5 context context NN cord-024189-t7mbsr25 188 6 , , , cord-024189-t7mbsr25 188 7 therefore therefore RB cord-024189-t7mbsr25 188 8 , , , cord-024189-t7mbsr25 188 9 certain certain JJ cord-024189-t7mbsr25 188 10 MRA MRA NNP cord-024189-t7mbsr25 188 11 fi fi NN cord-024189-t7mbsr25 188 12 ndings nding NNS cord-024189-t7mbsr25 188 13 may may MD cord-024189-t7mbsr25 188 14 be be VB cord-024189-t7mbsr25 188 15 diagnostic diagnostic JJ cord-024189-t7mbsr25 188 16 of of IN cord-024189-t7mbsr25 188 17 large large JJ cord-024189-t7mbsr25 188 18 vessel vessel NN cord-024189-t7mbsr25 188 19 vasculitis vasculitis NN cord-024189-t7mbsr25 188 20 . . . cord-024189-t7mbsr25 189 1 The the DT cord-024189-t7mbsr25 189 2 noninvasive noninvasive JJ cord-024189-t7mbsr25 189 3 nature nature NN cord-024189-t7mbsr25 189 4 of of IN cord-024189-t7mbsr25 189 5 MRA MRA NNP cord-024189-t7mbsr25 189 6 also also RB cord-024189-t7mbsr25 189 7 lends lend VBZ cord-024189-t7mbsr25 189 8 important important JJ cord-024189-t7mbsr25 189 9 advantages advantage NNS cord-024189-t7mbsr25 189 10 in in IN cord-024189-t7mbsr25 189 11 serial serial JJ cord-024189-t7mbsr25 189 12 monitoring monitoring NN cord-024189-t7mbsr25 189 13 . . . cord-024189-t7mbsr25 190 1 Unfortunately unfortunately RB cord-024189-t7mbsr25 190 2 , , , cord-024189-t7mbsr25 190 3 the the DT cord-024189-t7mbsr25 190 4 appropriate appropriate JJ cord-024189-t7mbsr25 190 5 interpretations interpretation NNS cord-024189-t7mbsr25 190 6 of of IN cord-024189-t7mbsr25 190 7 some some DT cord-024189-t7mbsr25 190 8 MRA MRA NNP cord-024189-t7mbsr25 190 9 fi fi IN cord-024189-t7mbsr25 190 10 ndings nding NNS cord-024189-t7mbsr25 190 11 , , , cord-024189-t7mbsr25 190 12 for for IN cord-024189-t7mbsr25 190 13 example example NN cord-024189-t7mbsr25 190 14 , , , cord-024189-t7mbsr25 190 15 enhancement enhancement NN cord-024189-t7mbsr25 190 16 of of IN cord-024189-t7mbsr25 190 17 the the DT cord-024189-t7mbsr25 190 18 vessel vessel NN cord-024189-t7mbsr25 190 19 wall wall NN cord-024189-t7mbsr25 190 20 following follow VBG cord-024189-t7mbsr25 190 21 gadolinium gadolinium NNP cord-024189-t7mbsr25 190 22 administration administration NNP cord-024189-t7mbsr25 190 23 and and CC cord-024189-t7mbsr25 190 24 the the DT cord-024189-t7mbsr25 190 25 presence presence NN cord-024189-t7mbsr25 190 26 of of IN cord-024189-t7mbsr25 190 27 vessel vessel NN cord-024189-t7mbsr25 190 28 wall wall NN cord-024189-t7mbsr25 190 29 edema edema NN cord-024189-t7mbsr25 190 30 , , , cord-024189-t7mbsr25 190 31 remain remain VBP cord-024189-t7mbsr25 190 32 uncertain uncertain JJ cord-024189-t7mbsr25 190 33 and and CC cord-024189-t7mbsr25 190 34 require require VBP cord-024189-t7mbsr25 190 35 additional additional JJ cord-024189-t7mbsr25 190 36 longitudinal longitudinal JJ cord-024189-t7mbsr25 190 37 studies study NNS cord-024189-t7mbsr25 190 38 . . . cord-024189-t7mbsr25 191 1 Computed compute VBN cord-024189-t7mbsr25 191 2 tomography tomography NN cord-024189-t7mbsr25 191 3 angiography angiography NN cord-024189-t7mbsr25 191 4 , , , cord-024189-t7mbsr25 191 5 another another DT cord-024189-t7mbsr25 191 6 promising promising JJ cord-024189-t7mbsr25 191 7 technique technique NN cord-024189-t7mbsr25 191 8 , , , cord-024189-t7mbsr25 191 9 has have VBZ cord-024189-t7mbsr25 191 10 not not RB cord-024189-t7mbsr25 191 11 been be VBN cord-024189-t7mbsr25 191 12 evaluated evaluate VBN cord-024189-t7mbsr25 191 13 thoroughly thoroughly RB cord-024189-t7mbsr25 191 14 in in IN cord-024189-t7mbsr25 191 15 large large JJ cord-024189-t7mbsr25 191 16 vessel vessel NN cord-024189-t7mbsr25 191 17 vasculitis vasculitis NN cord-024189-t7mbsr25 191 18 . . . cord-024189-t7mbsr25 192 1 Position position NN cord-024189-t7mbsr25 192 2 emission emission NN cord-024189-t7mbsr25 192 3 tomography tomography NN cord-024189-t7mbsr25 192 4 ( ( -LRB- cord-024189-t7mbsr25 192 5 PET PET NNP cord-024189-t7mbsr25 192 6 ) ) -RRB- cord-024189-t7mbsr25 192 7 with with IN cord-024189-t7mbsr25 192 8 18 18 CD cord-024189-t7mbsr25 192 9 F F NNP cord-024189-t7mbsr25 192 10 - - HYPH cord-024189-t7mbsr25 192 11 fl fl NNP cord-024189-t7mbsr25 192 12 uorodeoxyglucose uorodeoxyglucose NN cord-024189-t7mbsr25 192 13 also also RB cord-024189-t7mbsr25 192 14 holds hold VBZ cord-024189-t7mbsr25 192 15 promise promise NN cord-024189-t7mbsr25 192 16 for for IN cord-024189-t7mbsr25 192 17 the the DT cord-024189-t7mbsr25 192 18 assessment assessment NN cord-024189-t7mbsr25 192 19 of of IN cord-024189-t7mbsr25 192 20 the the DT cord-024189-t7mbsr25 192 21 degree degree NN cord-024189-t7mbsr25 192 22 of of IN cord-024189-t7mbsr25 192 23 disease disease NN cord-024189-t7mbsr25 192 24 activity activity NN cord-024189-t7mbsr25 192 25 in in IN cord-024189-t7mbsr25 192 26 large large JJ cord-024189-t7mbsr25 192 27 arteries artery NNS cord-024189-t7mbsr25 192 28 , , , cord-024189-t7mbsr25 192 29 but but CC cord-024189-t7mbsr25 192 30 has have VBZ cord-024189-t7mbsr25 192 31 not not RB cord-024189-t7mbsr25 192 32 yet yet RB cord-024189-t7mbsr25 192 33 been be VBN cord-024189-t7mbsr25 192 34 validated validate VBN cord-024189-t7mbsr25 192 35 for for IN cord-024189-t7mbsr25 192 36 general general JJ cord-024189-t7mbsr25 192 37 clinical clinical JJ cord-024189-t7mbsr25 192 38 use use NN cord-024189-t7mbsr25 192 39 . . . cord-024189-t7mbsr25 193 1 Other other JJ cord-024189-t7mbsr25 193 2 noninvasive noninvasive JJ cord-024189-t7mbsr25 193 3 vascular vascular JJ cord-024189-t7mbsr25 193 4 studies study NNS cord-024189-t7mbsr25 193 5 , , , cord-024189-t7mbsr25 193 6 including include VBG cord-024189-t7mbsr25 193 7 fl fl NNP cord-024189-t7mbsr25 193 8 uorescein uorescein NNP cord-024189-t7mbsr25 193 9 angiography angiography NNP cord-024189-t7mbsr25 193 10 , , , cord-024189-t7mbsr25 193 11 transcranial transcranial JJ cord-024189-t7mbsr25 193 12 Doppler Doppler NNP cord-024189-t7mbsr25 193 13 fl fl NNP cord-024189-t7mbsr25 193 14 ow ow NNP cord-024189-t7mbsr25 193 15 studies study NNS cord-024189-t7mbsr25 193 16 , , , cord-024189-t7mbsr25 193 17 and and CC cord-024189-t7mbsr25 193 18 Doppler Doppler NNP cord-024189-t7mbsr25 193 19 ultrasonography ultrasonography NN cord-024189-t7mbsr25 193 20 , , , cord-024189-t7mbsr25 193 21 are be VBP cord-024189-t7mbsr25 193 22 useful useful JJ cord-024189-t7mbsr25 193 23 in in IN cord-024189-t7mbsr25 193 24 assessing assess VBG cord-024189-t7mbsr25 193 25 certain certain JJ cord-024189-t7mbsr25 193 26 vascular vascular JJ cord-024189-t7mbsr25 193 27 beds bed NNS cord-024189-t7mbsr25 193 28 , , , cord-024189-t7mbsr25 193 29 for for IN cord-024189-t7mbsr25 193 30 example example NN cord-024189-t7mbsr25 193 31 , , , cord-024189-t7mbsr25 193 32 the the DT cord-024189-t7mbsr25 193 33 retinal retinal JJ cord-024189-t7mbsr25 193 34 , , , cord-024189-t7mbsr25 193 35 vertebral vertebral JJ cord-024189-t7mbsr25 193 36 , , , cord-024189-t7mbsr25 193 37 or or CC cord-024189-t7mbsr25 193 38 subclavian subclavian JJ cord-024189-t7mbsr25 193 39 arteries artery NNS cord-024189-t7mbsr25 193 40 . . . cord-024189-t7mbsr25 194 1 These these DT cord-024189-t7mbsr25 194 2 techniques technique NNS cord-024189-t7mbsr25 194 3 only only RB cord-024189-t7mbsr25 194 4 identify identify VBP cord-024189-t7mbsr25 194 5 vascular vascular JJ cord-024189-t7mbsr25 194 6 insuffi insuffi NN cord-024189-t7mbsr25 194 7 ciency ciency NN cord-024189-t7mbsr25 194 8 in in IN cord-024189-t7mbsr25 194 9 cases case NNS cord-024189-t7mbsr25 194 10 with with IN cord-024189-t7mbsr25 194 11 pronounced pronounced JJ cord-024189-t7mbsr25 194 12 , , , cord-024189-t7mbsr25 194 13 lumen lumen NN cord-024189-t7mbsr25 194 14 - - HYPH cord-024189-t7mbsr25 194 15 stenosing stenose VBG cord-024189-t7mbsr25 194 16 disease disease NN cord-024189-t7mbsr25 194 17 , , , cord-024189-t7mbsr25 194 18 however however RB cord-024189-t7mbsr25 194 19 , , , cord-024189-t7mbsr25 194 20 and and CC cord-024189-t7mbsr25 194 21 do do VBP cord-024189-t7mbsr25 194 22 not not RB cord-024189-t7mbsr25 194 23 provide provide VB cord-024189-t7mbsr25 194 24 specifi specifi NNP cord-024189-t7mbsr25 194 25 c c NN cord-024189-t7mbsr25 194 26 information information NN cord-024189-t7mbsr25 194 27 useful useful JJ cord-024189-t7mbsr25 194 28 from from IN cord-024189-t7mbsr25 194 29 the the DT cord-024189-t7mbsr25 194 30 standpoint standpoint NN cord-024189-t7mbsr25 194 31 of of IN cord-024189-t7mbsr25 194 32 diagnosis diagnosis NN cord-024189-t7mbsr25 194 33 . . . cord-024189-t7mbsr25 195 1 Although although IN cord-024189-t7mbsr25 195 2 Doppler Doppler NNP cord-024189-t7mbsr25 195 3 ultrasound ultrasound NN cord-024189-t7mbsr25 195 4 was be VBD cord-024189-t7mbsr25 195 5 once once RB cord-024189-t7mbsr25 195 6 hypothesized hypothesize VBN cord-024189-t7mbsr25 195 7 to to TO cord-024189-t7mbsr25 195 8 be be VB cord-024189-t7mbsr25 195 9 useful useful JJ cord-024189-t7mbsr25 195 10 in in IN cord-024189-t7mbsr25 195 11 the the DT cord-024189-t7mbsr25 195 12 diagnosis diagnosis NN cord-024189-t7mbsr25 195 13 of of IN cord-024189-t7mbsr25 195 14 GCA GCA NNP cord-024189-t7mbsr25 195 15 , , , cord-024189-t7mbsr25 195 16 the the DT cord-024189-t7mbsr25 195 17 value value NN cord-024189-t7mbsr25 195 18 of of IN cord-024189-t7mbsr25 195 19 identifying identify VBG cord-024189-t7mbsr25 195 20 a a DT cord-024189-t7mbsr25 195 21 " " `` cord-024189-t7mbsr25 195 22 hyperechoic hyperechoic JJ cord-024189-t7mbsr25 195 23 halo halo NN cord-024189-t7mbsr25 195 24 " " '' cord-024189-t7mbsr25 195 25 on on IN cord-024189-t7mbsr25 195 26 ultrasound ultrasound NN cord-024189-t7mbsr25 195 27 in in IN cord-024189-t7mbsr25 195 28 the the DT cord-024189-t7mbsr25 195 29 temporal temporal JJ cord-024189-t7mbsr25 195 30 artery artery NN cord-024189-t7mbsr25 195 31 has have VBZ cord-024189-t7mbsr25 195 32 not not RB cord-024189-t7mbsr25 195 33 been be VBN cord-024189-t7mbsr25 195 34 confi confi VBN cord-024189-t7mbsr25 195 35 rmed rme VBN cord-024189-t7mbsr25 195 36 in in IN cord-024189-t7mbsr25 195 37 subsequent subsequent JJ cord-024189-t7mbsr25 195 38 studies study NNS cord-024189-t7mbsr25 195 39 ( ( -LRB- cord-024189-t7mbsr25 195 40 18 18 CD cord-024189-t7mbsr25 195 41 ) ) -RRB- cord-024189-t7mbsr25 195 42 . . . cord-024189-t7mbsr25 196 1 Glucocorticoids glucocorticoid NNS cord-024189-t7mbsr25 196 2 are be VBP cord-024189-t7mbsr25 196 3 explicitly explicitly RB cord-024189-t7mbsr25 196 4 effective effective JJ cord-024189-t7mbsr25 196 5 in in IN cord-024189-t7mbsr25 196 6 suppressing suppress VBG cord-024189-t7mbsr25 196 7 clinical clinical JJ cord-024189-t7mbsr25 196 8 manifestations manifestation NNS cord-024189-t7mbsr25 196 9 of of IN cord-024189-t7mbsr25 196 10 GCA GCA NNP cord-024189-t7mbsr25 196 11 . . . cord-024189-t7mbsr25 197 1 Since since IN cord-024189-t7mbsr25 197 2 the the DT cord-024189-t7mbsr25 197 3 introduction introduction NN cord-024189-t7mbsr25 197 4 of of IN cord-024189-t7mbsr25 197 5 glucocorticoids glucocorticoid NNS cord-024189-t7mbsr25 197 6 , , , cord-024189-t7mbsr25 197 7 the the DT cord-024189-t7mbsr25 197 8 rate rate NN cord-024189-t7mbsr25 197 9 of of IN cord-024189-t7mbsr25 197 10 GCA GCA NNP cord-024189-t7mbsr25 197 11 - - HYPH cord-024189-t7mbsr25 197 12 related relate VBN cord-024189-t7mbsr25 197 13 blindness blindness NN cord-024189-t7mbsr25 197 14 has have VBZ cord-024189-t7mbsr25 197 15 declined decline VBN cord-024189-t7mbsr25 197 16 , , , cord-024189-t7mbsr25 197 17 documenting document VBG cord-024189-t7mbsr25 197 18 the the DT cord-024189-t7mbsr25 197 19 effectiveness effectiveness NN cord-024189-t7mbsr25 197 20 of of IN cord-024189-t7mbsr25 197 21 this this DT cord-024189-t7mbsr25 197 22 immunosuppressive immunosuppressive JJ cord-024189-t7mbsr25 197 23 approach approach NN cord-024189-t7mbsr25 197 24 . . . cord-024189-t7mbsr25 198 1 In in IN cord-024189-t7mbsr25 198 2 almost almost RB cord-024189-t7mbsr25 198 3 all all DT cord-024189-t7mbsr25 198 4 patients patient NNS cord-024189-t7mbsr25 198 5 , , , cord-024189-t7mbsr25 198 6 glucocorticoids glucocorticoid NNS cord-024189-t7mbsr25 198 7 induce induce VBP cord-024189-t7mbsr25 198 8 relief relief NN cord-024189-t7mbsr25 198 9 within within IN cord-024189-t7mbsr25 198 10 12 12 CD cord-024189-t7mbsr25 198 11 to to TO cord-024189-t7mbsr25 198 12 48 48 CD cord-024189-t7mbsr25 198 13 hours hour NNS cord-024189-t7mbsr25 198 14 . . . cord-024189-t7mbsr25 199 1 The the DT cord-024189-t7mbsr25 199 2 excellent excellent JJ cord-024189-t7mbsr25 199 3 response response NN cord-024189-t7mbsr25 199 4 of of IN cord-024189-t7mbsr25 199 5 the the DT cord-024189-t7mbsr25 199 6 disease disease NN cord-024189-t7mbsr25 199 7 to to IN cord-024189-t7mbsr25 199 8 this this DT cord-024189-t7mbsr25 199 9 therapy therapy NN cord-024189-t7mbsr25 199 10 has have VBZ cord-024189-t7mbsr25 199 11 been be VBN cord-024189-t7mbsr25 199 12 suggested suggest VBN cord-024189-t7mbsr25 199 13 by by IN cord-024189-t7mbsr25 199 14 some some DT cord-024189-t7mbsr25 199 15 as as IN cord-024189-t7mbsr25 199 16 a a DT cord-024189-t7mbsr25 199 17 diagnostic diagnostic JJ cord-024189-t7mbsr25 199 18 criterion criterion NN cord-024189-t7mbsr25 199 19 . . . cord-024189-t7mbsr25 200 1 In in IN cord-024189-t7mbsr25 200 2 view view NN cord-024189-t7mbsr25 200 3 of of IN cord-024189-t7mbsr25 200 4 the the DT cord-024189-t7mbsr25 200 5 severity severity NN cord-024189-t7mbsr25 200 6 of of IN cord-024189-t7mbsr25 200 7 GCA GCA NNP cord-024189-t7mbsr25 200 8 - - HYPH cord-024189-t7mbsr25 200 9 related relate VBN cord-024189-t7mbsr25 200 10 morbidity morbidity NN cord-024189-t7mbsr25 200 11 , , , cord-024189-t7mbsr25 200 12 initial initial JJ cord-024189-t7mbsr25 200 13 doses dose NNS cord-024189-t7mbsr25 200 14 of of IN cord-024189-t7mbsr25 200 15 60 60 CD cord-024189-t7mbsr25 200 16 mg mg NNP cord-024189-t7mbsr25 200 17 prednisone prednisone NN cord-024189-t7mbsr25 200 18 or or CC cord-024189-t7mbsr25 200 19 equivalent equivalent JJ cord-024189-t7mbsr25 200 20 have have VBP cord-024189-t7mbsr25 200 21 been be VBN cord-024189-t7mbsr25 200 22 recommended recommend VBN cord-024189-t7mbsr25 200 23 . . . cord-024189-t7mbsr25 201 1 Glucocorticoids Glucocorticoids NNP cord-024189-t7mbsr25 201 2 can can MD cord-024189-t7mbsr25 201 3 not not RB cord-024189-t7mbsr25 201 4 reverse reverse VB cord-024189-t7mbsr25 201 5 intimal intimal JJ cord-024189-t7mbsr25 201 6 hyperplasia hyperplasia NN cord-024189-t7mbsr25 201 7 but but CC cord-024189-t7mbsr25 201 8 may may MD cord-024189-t7mbsr25 201 9 help help VB cord-024189-t7mbsr25 201 10 attenuate attenuate VB cord-024189-t7mbsr25 201 11 the the DT cord-024189-t7mbsr25 201 12 ischemic ischemic JJ cord-024189-t7mbsr25 201 13 insult insult NN cord-024189-t7mbsr25 201 14 by by IN cord-024189-t7mbsr25 201 15 reducing reduce VBG cord-024189-t7mbsr25 201 16 tissue tissue NN cord-024189-t7mbsr25 201 17 edema edema NN cord-024189-t7mbsr25 201 18 . . . cord-024189-t7mbsr25 202 1 In in IN cord-024189-t7mbsr25 202 2 ophthalmologic ophthalmologic JJ cord-024189-t7mbsr25 202 3 emergencies emergency NNS cord-024189-t7mbsr25 202 4 ( ( -LRB- cord-024189-t7mbsr25 202 5 e.g. e.g. RB cord-024189-t7mbsr25 202 6 , , , cord-024189-t7mbsr25 202 7 amaurosis amaurosis NN cord-024189-t7mbsr25 202 8 fugax fugax NN cord-024189-t7mbsr25 202 9 occurring occur VBG cord-024189-t7mbsr25 202 10 in in IN cord-024189-t7mbsr25 202 11 suspected suspect VBN cord-024189-t7mbsr25 202 12 GCA GCA NNP cord-024189-t7mbsr25 202 13 ) ) -RRB- cord-024189-t7mbsr25 202 14 , , , cord-024189-t7mbsr25 202 15 pulse pulse NN cord-024189-t7mbsr25 202 16 glucocorticoids glucocorticoid NNS cord-024189-t7mbsr25 202 17 may may MD cord-024189-t7mbsr25 202 18 be be VB cord-024189-t7mbsr25 202 19 appropriate appropriate JJ cord-024189-t7mbsr25 202 20 ( ( -LRB- cord-024189-t7mbsr25 202 21 19 19 CD cord-024189-t7mbsr25 202 22 ) ) -RRB- cord-024189-t7mbsr25 202 23 . . . cord-024189-t7mbsr25 203 1 Initial initial JJ cord-024189-t7mbsr25 203 2 doses dose NNS cord-024189-t7mbsr25 203 3 should should MD cord-024189-t7mbsr25 203 4 be be VB cord-024189-t7mbsr25 203 5 maintained maintain VBN cord-024189-t7mbsr25 203 6 until until IN cord-024189-t7mbsr25 203 7 reversible reversible JJ cord-024189-t7mbsr25 203 8 manifestations manifestation NNS cord-024189-t7mbsr25 203 9 of of IN cord-024189-t7mbsr25 203 10 the the DT cord-024189-t7mbsr25 203 11 disease disease NN cord-024189-t7mbsr25 203 12 have have VBP cord-024189-t7mbsr25 203 13 responded respond VBN cord-024189-t7mbsr25 203 14 and and CC cord-024189-t7mbsr25 203 15 the the DT cord-024189-t7mbsr25 203 16 systemic systemic JJ cord-024189-t7mbsr25 203 17 infl infl NNP cord-024189-t7mbsr25 203 18 ammatory ammatory NNP cord-024189-t7mbsr25 203 19 syndrome syndrome NNP cord-024189-t7mbsr25 203 20 is be VBZ cord-024189-t7mbsr25 203 21 suppressed suppress VBN cord-024189-t7mbsr25 203 22 . . . cord-024189-t7mbsr25 204 1 Subsequently subsequently RB cord-024189-t7mbsr25 204 2 , , , cord-024189-t7mbsr25 204 3 under under IN cord-024189-t7mbsr25 204 4 close close JJ cord-024189-t7mbsr25 204 5 monitoring monitoring NN cord-024189-t7mbsr25 204 6 for for IN cord-024189-t7mbsr25 204 7 clinical clinical JJ cord-024189-t7mbsr25 204 8 signs sign NNS cord-024189-t7mbsr25 204 9 of of IN cord-024189-t7mbsr25 204 10 disease disease NN cord-024189-t7mbsr25 204 11 reactivation reactivation NN cord-024189-t7mbsr25 204 12 , , , cord-024189-t7mbsr25 204 13 the the DT cord-024189-t7mbsr25 204 14 dose dose NN cord-024189-t7mbsr25 204 15 of of IN cord-024189-t7mbsr25 204 16 prednisone prednisone NN cord-024189-t7mbsr25 204 17 generally generally RB cord-024189-t7mbsr25 204 18 can can MD cord-024189-t7mbsr25 204 19 be be VB cord-024189-t7mbsr25 204 20 tapered taper VBN cord-024189-t7mbsr25 204 21 by by IN cord-024189-t7mbsr25 204 22 10 10 CD cord-024189-t7mbsr25 204 23 % % NN cord-024189-t7mbsr25 204 24 every every DT cord-024189-t7mbsr25 204 25 1 1 CD cord-024189-t7mbsr25 204 26 to to TO cord-024189-t7mbsr25 204 27 2 2 CD cord-024189-t7mbsr25 204 28 weeks week NNS cord-024189-t7mbsr25 204 29 . . . cord-024189-t7mbsr25 205 1 So so RB cord-024189-t7mbsr25 205 2 far far RB cord-024189-t7mbsr25 205 3 , , , cord-024189-t7mbsr25 205 4 the the DT cord-024189-t7mbsr25 205 5 use use NN cord-024189-t7mbsr25 205 6 of of IN cord-024189-t7mbsr25 205 7 glucocorticoid glucocorticoid NN cord-024189-t7mbsr25 205 8 - - HYPH cord-024189-t7mbsr25 205 9 sparing spare VBG cord-024189-t7mbsr25 205 10 agents agent NNS cord-024189-t7mbsr25 205 11 to to TO cord-024189-t7mbsr25 205 12 allow allow VB cord-024189-t7mbsr25 205 13 a a DT cord-024189-t7mbsr25 205 14 more more RBR cord-024189-t7mbsr25 205 15 rapid rapid JJ cord-024189-t7mbsr25 205 16 taper taper NN cord-024189-t7mbsr25 205 17 has have VBZ cord-024189-t7mbsr25 205 18 been be VBN cord-024189-t7mbsr25 205 19 unsuccessful unsuccessful JJ cord-024189-t7mbsr25 205 20 ( ( -LRB- cord-024189-t7mbsr25 205 21 17 17 CD cord-024189-t7mbsr25 205 22 ) ) -RRB- cord-024189-t7mbsr25 205 23 . . . cord-024189-t7mbsr25 206 1 Initial initial JJ cord-024189-t7mbsr25 206 2 positive positive JJ cord-024189-t7mbsr25 206 3 results result NNS cord-024189-t7mbsr25 206 4 with with IN cord-024189-t7mbsr25 206 5 methotrexate methotrexate NNP cord-024189-t7mbsr25 206 6 could could MD cord-024189-t7mbsr25 206 7 not not RB cord-024189-t7mbsr25 206 8 be be VB cord-024189-t7mbsr25 206 9 confi confi NNP cord-024189-t7mbsr25 206 10 rmed rme VBN cord-024189-t7mbsr25 206 11 in in IN cord-024189-t7mbsr25 206 12 a a DT cord-024189-t7mbsr25 206 13 subsequent subsequent JJ cord-024189-t7mbsr25 206 14 study study NN cord-024189-t7mbsr25 206 15 ( ( -LRB- cord-024189-t7mbsr25 206 16 20 20 CD cord-024189-t7mbsr25 206 17 ) ) -RRB- cord-024189-t7mbsr25 206 18 . . . cord-024189-t7mbsr25 207 1 A a DT cord-024189-t7mbsr25 207 2 recent recent JJ cord-024189-t7mbsr25 207 3 randomized randomized JJ cord-024189-t7mbsr25 207 4 , , , cord-024189-t7mbsr25 207 5 controlled control VBN cord-024189-t7mbsr25 207 6 trial trial NN cord-024189-t7mbsr25 207 7 of of IN cord-024189-t7mbsr25 207 8 tumor tumor NN cord-024189-t7mbsr25 207 9 necrosing necrosing NNP cord-024189-t7mbsr25 207 10 factor factor NN cord-024189-t7mbsr25 207 11 ( ( -LRB- cord-024189-t7mbsr25 207 12 TNF TNF NNP cord-024189-t7mbsr25 207 13 ) ) -RRB- cord-024189-t7mbsr25 207 14 alpha alpha NN cord-024189-t7mbsr25 207 15 blockade blockade NN cord-024189-t7mbsr25 207 16 found find VBD cord-024189-t7mbsr25 207 17 this this DT cord-024189-t7mbsr25 207 18 therapy therapy NN cord-024189-t7mbsr25 207 19 to to TO cord-024189-t7mbsr25 207 20 be be VB cord-024189-t7mbsr25 207 21 ineffective ineffective JJ cord-024189-t7mbsr25 207 22 as as IN cord-024189-t7mbsr25 207 23 a a DT cord-024189-t7mbsr25 207 24 glucocorticoid glucocorticoid NN cord-024189-t7mbsr25 207 25 - - HYPH cord-024189-t7mbsr25 207 26 sparing spare VBG cord-024189-t7mbsr25 207 27 medication medication NN cord-024189-t7mbsr25 207 28 ( ( -LRB- cord-024189-t7mbsr25 207 29 21 21 CD cord-024189-t7mbsr25 207 30 ) ) -RRB- cord-024189-t7mbsr25 207 31 . . . cord-024189-t7mbsr25 208 1 A a DT cord-024189-t7mbsr25 208 2 recent recent JJ cord-024189-t7mbsr25 208 3 study study NN cord-024189-t7mbsr25 208 4 suggests suggest VBZ cord-024189-t7mbsr25 208 5 that that IN cord-024189-t7mbsr25 208 6 a a DT cord-024189-t7mbsr25 208 7 more more RBR cord-024189-t7mbsr25 208 8 aggressive aggressive JJ cord-024189-t7mbsr25 208 9 induction induction NN cord-024189-t7mbsr25 208 10 therapy therapy NN cord-024189-t7mbsr25 208 11 at at IN cord-024189-t7mbsr25 208 12 the the DT cord-024189-t7mbsr25 208 13 onset onset NN cord-024189-t7mbsr25 208 14 of of IN cord-024189-t7mbsr25 208 15 the the DT cord-024189-t7mbsr25 208 16 disease disease NN cord-024189-t7mbsr25 208 17 , , , cord-024189-t7mbsr25 208 18 including include VBG cord-024189-t7mbsr25 208 19 three three CD cord-024189-t7mbsr25 208 20 daily daily JJ cord-024189-t7mbsr25 208 21 pulses pulse NNS cord-024189-t7mbsr25 208 22 of of IN cord-024189-t7mbsr25 208 23 1 1 CD cord-024189-t7mbsr25 208 24 gram gram NN cord-024189-t7mbsr25 208 25 of of IN cord-024189-t7mbsr25 208 26 methylprednisolone methylprednisolone NN cord-024189-t7mbsr25 208 27 , , , cord-024189-t7mbsr25 208 28 may may MD cord-024189-t7mbsr25 208 29 allow allow VB cord-024189-t7mbsr25 208 30 for for IN cord-024189-t7mbsr25 208 31 a a DT cord-024189-t7mbsr25 208 32 rapid rapid JJ cord-024189-t7mbsr25 208 33 tapering tapering NN cord-024189-t7mbsr25 208 34 of of IN cord-024189-t7mbsr25 208 35 glucocorticoids glucocorticoid NNS cord-024189-t7mbsr25 208 36 and and CC cord-024189-t7mbsr25 208 37 , , , cord-024189-t7mbsr25 208 38 in in IN cord-024189-t7mbsr25 208 39 particular particular JJ cord-024189-t7mbsr25 208 40 , , , cord-024189-t7mbsr25 208 41 a a DT cord-024189-t7mbsr25 208 42 discontinuation discontinuation NN cord-024189-t7mbsr25 208 43 of of IN cord-024189-t7mbsr25 208 44 glucocorticoids glucocorticoid NNS cord-024189-t7mbsr25 208 45 in in IN cord-024189-t7mbsr25 208 46 the the DT cord-024189-t7mbsr25 208 47 second second JJ cord-024189-t7mbsr25 208 48 year year NN cord-024189-t7mbsr25 208 49 of of IN cord-024189-t7mbsr25 208 50 disease disease NNP cord-024189-t7mbsr25 208 51 ( ( -LRB- cord-024189-t7mbsr25 208 52 22 22 CD cord-024189-t7mbsr25 208 53 ) ) -RRB- cord-024189-t7mbsr25 208 54 . . . cord-024189-t7mbsr25 209 1 Aspirin aspirin NN cord-024189-t7mbsr25 209 2 is be VBZ cord-024189-t7mbsr25 209 3 an an DT cord-024189-t7mbsr25 209 4 important important JJ cord-024189-t7mbsr25 209 5 adjunctive adjunctive JJ cord-024189-t7mbsr25 209 6 treatment treatment NN cord-024189-t7mbsr25 209 7 for for IN cord-024189-t7mbsr25 209 8 GCA GCA NNP cord-024189-t7mbsr25 209 9 patients patient NNS cord-024189-t7mbsr25 209 10 without without IN cord-024189-t7mbsr25 209 11 contraindications contraindication NNS cord-024189-t7mbsr25 209 12 . . . cord-024189-t7mbsr25 210 1 Retrospective retrospective JJ cord-024189-t7mbsr25 210 2 studies study NNS cord-024189-t7mbsr25 210 3 have have VBP cord-024189-t7mbsr25 210 4 indicated indicate VBN cord-024189-t7mbsr25 210 5 strong strong JJ cord-024189-t7mbsr25 210 6 reductions reduction NNS cord-024189-t7mbsr25 210 7 in in IN cord-024189-t7mbsr25 210 8 the the DT cord-024189-t7mbsr25 210 9 risks risk NNS cord-024189-t7mbsr25 210 10 of of IN cord-024189-t7mbsr25 210 11 visual visual JJ cord-024189-t7mbsr25 210 12 loss loss NN cord-024189-t7mbsr25 210 13 and and CC cord-024189-t7mbsr25 210 14 central central JJ cord-024189-t7mbsr25 210 15 nervous nervous JJ cord-024189-t7mbsr25 210 16 system system NN cord-024189-t7mbsr25 210 17 ischemic ischemic JJ cord-024189-t7mbsr25 210 18 events event NNS cord-024189-t7mbsr25 210 19 among among IN cord-024189-t7mbsr25 210 20 patients patient NNS cord-024189-t7mbsr25 210 21 taking take VBG cord-024189-t7mbsr25 210 22 aspirin aspirin NN cord-024189-t7mbsr25 210 23 for for IN cord-024189-t7mbsr25 210 24 other other JJ cord-024189-t7mbsr25 210 25 reasons reason NNS cord-024189-t7mbsr25 210 26 at at IN cord-024189-t7mbsr25 210 27 the the DT cord-024189-t7mbsr25 210 28 time time NN cord-024189-t7mbsr25 210 29 their -PRON- PRP$ cord-024189-t7mbsr25 210 30 GCA GCA NNP cord-024189-t7mbsr25 210 31 was be VBD cord-024189-t7mbsr25 210 32 diagnosed diagnose VBN cord-024189-t7mbsr25 210 33 ( ( -LRB- cord-024189-t7mbsr25 210 34 23 23 CD cord-024189-t7mbsr25 210 35 ) ) -RRB- cord-024189-t7mbsr25 210 36 . . . cord-024189-t7mbsr25 211 1 The the DT cord-024189-t7mbsr25 211 2 mechanism mechanism NN cord-024189-t7mbsr25 211 3 of of IN cord-024189-t7mbsr25 211 4 aspirin aspirin NN cord-024189-t7mbsr25 211 5 's 's POS cord-024189-t7mbsr25 211 6 effi effi NNP cord-024189-t7mbsr25 211 7 cacy cacy NN cord-024189-t7mbsr25 211 8 in in IN cord-024189-t7mbsr25 211 9 this this DT cord-024189-t7mbsr25 211 10 setting setting NN cord-024189-t7mbsr25 211 11 is be VBZ cord-024189-t7mbsr25 211 12 not not RB cord-024189-t7mbsr25 211 13 entirely entirely RB cord-024189-t7mbsr25 211 14 clear clear JJ cord-024189-t7mbsr25 211 15 , , , cord-024189-t7mbsr25 211 16 but but CC cord-024189-t7mbsr25 211 17 the the DT cord-024189-t7mbsr25 211 18 medication medication NN cord-024189-t7mbsr25 211 19 may may MD cord-024189-t7mbsr25 211 20 exert exert VB cord-024189-t7mbsr25 211 21 its -PRON- PRP$ cord-024189-t7mbsr25 211 22 effect effect NN cord-024189-t7mbsr25 211 23 through through IN cord-024189-t7mbsr25 211 24 the the DT cord-024189-t7mbsr25 211 25 selective selective JJ cord-024189-t7mbsr25 211 26 suppression suppression NN cord-024189-t7mbsr25 211 27 of of IN cord-024189-t7mbsr25 211 28 interferon interferon NN cord-024189-t7mbsr25 211 29 gamma gamma NN cord-024189-t7mbsr25 211 30 production production NN cord-024189-t7mbsr25 211 31 ( ( -LRB- cord-024189-t7mbsr25 211 32 17 17 CD cord-024189-t7mbsr25 211 33 ) ) -RRB- cord-024189-t7mbsr25 211 34 . . . cord-024189-t7mbsr25 212 1 Although although IN cord-024189-t7mbsr25 212 2 the the DT cord-024189-t7mbsr25 212 3 optimal optimal JJ cord-024189-t7mbsr25 212 4 dose dose NN cord-024189-t7mbsr25 212 5 of of IN cord-024189-t7mbsr25 212 6 aspirin aspirin NN cord-024189-t7mbsr25 212 7 has have VBZ cord-024189-t7mbsr25 212 8 not not RB cord-024189-t7mbsr25 212 9 been be VBN cord-024189-t7mbsr25 212 10 established establish VBN cord-024189-t7mbsr25 212 11 , , , cord-024189-t7mbsr25 212 12 doses dose NNS cord-024189-t7mbsr25 212 13 ranging range VBG cord-024189-t7mbsr25 212 14 from from IN cord-024189-t7mbsr25 212 15 81 81 CD cord-024189-t7mbsr25 212 16 mg mg NNP cord-024189-t7mbsr25 212 17 / / SYM cord-024189-t7mbsr25 212 18 day day NN cord-024189-t7mbsr25 212 19 to to IN cord-024189-t7mbsr25 212 20 325 325 CD cord-024189-t7mbsr25 212 21 mg mg NNP cord-024189-t7mbsr25 212 22 / / SYM cord-024189-t7mbsr25 212 23 day day NN cord-024189-t7mbsr25 212 24 may may MD cord-024189-t7mbsr25 212 25 be be VB cord-024189-t7mbsr25 212 26 benefi benefi NNP cord-024189-t7mbsr25 212 27 cial cial NNP cord-024189-t7mbsr25 212 28 . . . cord-024189-t7mbsr25 213 1 The the DT cord-024189-t7mbsr25 213 2 most most JJS cord-024189-t7mbsr25 213 3 signifi signifi NN cord-024189-t7mbsr25 213 4 ca can MD cord-024189-t7mbsr25 213 5 nt not RB cord-024189-t7mbsr25 213 6 morbidity morbidity NN cord-024189-t7mbsr25 213 7 of of IN cord-024189-t7mbsr25 213 8 GCA GCA NNP cord-024189-t7mbsr25 213 9 relates relate VBZ cord-024189-t7mbsr25 213 10 to to IN cord-024189-t7mbsr25 213 11 reduced reduce VBN cord-024189-t7mbsr25 213 12 blood blood NN cord-024189-t7mbsr25 213 13 fl fl NNP cord-024189-t7mbsr25 213 14 ow ow UH cord-024189-t7mbsr25 213 15 to to IN cord-024189-t7mbsr25 213 16 the the DT cord-024189-t7mbsr25 213 17 eye eye NN cord-024189-t7mbsr25 213 18 and and CC cord-024189-t7mbsr25 213 19 optic optic JJ cord-024189-t7mbsr25 213 20 nerve nerve NN cord-024189-t7mbsr25 213 21 as as RB cord-024189-t7mbsr25 213 22 well well RB cord-024189-t7mbsr25 213 23 as as IN cord-024189-t7mbsr25 213 24 hypoperfusion hypoperfusion NN cord-024189-t7mbsr25 213 25 of of IN cord-024189-t7mbsr25 213 26 the the DT cord-024189-t7mbsr25 213 27 brain brain NN cord-024189-t7mbsr25 213 28 ( ( -LRB- cord-024189-t7mbsr25 213 29 19 19 CD cord-024189-t7mbsr25 213 30 ) ) -RRB- cord-024189-t7mbsr25 213 31 . . . cord-024189-t7mbsr25 214 1 If if IN cord-024189-t7mbsr25 214 2 diagnosed diagnose VBN cord-024189-t7mbsr25 214 3 and and CC cord-024189-t7mbsr25 214 4 treated treat VBN cord-024189-t7mbsr25 214 5 promptly promptly RB cord-024189-t7mbsr25 214 6 , , , cord-024189-t7mbsr25 214 7 progression progression NN cord-024189-t7mbsr25 214 8 of of IN cord-024189-t7mbsr25 214 9 the the DT cord-024189-t7mbsr25 214 10 downstream downstream JJ cord-024189-t7mbsr25 214 11 effects effect NNS cord-024189-t7mbsr25 214 12 of of IN cord-024189-t7mbsr25 214 13 arterial arterial JJ cord-024189-t7mbsr25 214 14 wall wall NN cord-024189-t7mbsr25 214 15 infl infl NNP cord-024189-t7mbsr25 214 16 ammation ammation NNP cord-024189-t7mbsr25 214 17 , , , cord-024189-t7mbsr25 214 18 in in IN cord-024189-t7mbsr25 214 19 particular particular JJ cord-024189-t7mbsr25 214 20 lumen lumen JJ cord-024189-t7mbsr25 214 21 occlusion occlusion NN cord-024189-t7mbsr25 214 22 with with IN cord-024189-t7mbsr25 214 23 tissue tissue NN cord-024189-t7mbsr25 214 24 ischemia ischemia NN cord-024189-t7mbsr25 214 25 , , , cord-024189-t7mbsr25 214 26 can can MD cord-024189-t7mbsr25 214 27 be be VB cord-024189-t7mbsr25 214 28 prevented prevent VBN cord-024189-t7mbsr25 214 29 . . . cord-024189-t7mbsr25 215 1 Side side JJ cord-024189-t7mbsr25 215 2 effects effect NNS cord-024189-t7mbsr25 215 3 of of IN cord-024189-t7mbsr25 215 4 high high JJ cord-024189-t7mbsr25 215 5 doses dose NNS cord-024189-t7mbsr25 215 6 of of IN cord-024189-t7mbsr25 215 7 glucocorticoids glucocorticoid NNS cord-024189-t7mbsr25 215 8 given give VBN cord-024189-t7mbsr25 215 9 over over IN cord-024189-t7mbsr25 215 10 a a DT cord-024189-t7mbsr25 215 11 prolonged prolonged JJ cord-024189-t7mbsr25 215 12 period period NN cord-024189-t7mbsr25 215 13 of of IN cord-024189-t7mbsr25 215 14 time time NN cord-024189-t7mbsr25 215 15 can can MD cord-024189-t7mbsr25 215 16 be be VB cord-024189-t7mbsr25 215 17 serious serious JJ cord-024189-t7mbsr25 215 18 , , , cord-024189-t7mbsr25 215 19 especially especially RB cord-024189-t7mbsr25 215 20 in in IN cord-024189-t7mbsr25 215 21 patients patient NNS cord-024189-t7mbsr25 215 22 older old JJR cord-024189-t7mbsr25 215 23 than than IN cord-024189-t7mbsr25 215 24 50 50 CD cord-024189-t7mbsr25 215 25 years year NNS cord-024189-t7mbsr25 215 26 , , , cord-024189-t7mbsr25 215 27 and and CC cord-024189-t7mbsr25 215 28 treatment treatment NN cord-024189-t7mbsr25 215 29 should should MD cord-024189-t7mbsr25 215 30 therefore therefore RB cord-024189-t7mbsr25 215 31 only only RB cord-024189-t7mbsr25 215 32 be be VB cord-024189-t7mbsr25 215 33 initiated initiate VBN cord-024189-t7mbsr25 215 34 if if IN cord-024189-t7mbsr25 215 35 the the DT cord-024189-t7mbsr25 215 36 diagnosis diagnosis NN cord-024189-t7mbsr25 215 37 is be VBZ cord-024189-t7mbsr25 215 38 confi confi NNP cord-024189-t7mbsr25 215 39 rmed rmed NNP cord-024189-t7mbsr25 215 40 . . . cord-024189-t7mbsr25 216 1 In in IN cord-024189-t7mbsr25 216 2 the the DT cord-024189-t7mbsr25 216 3 majority majority NN cord-024189-t7mbsr25 216 4 of of IN cord-024189-t7mbsr25 216 5 patients patient NNS cord-024189-t7mbsr25 216 6 , , , cord-024189-t7mbsr25 216 7 GCA GCA NNP cord-024189-t7mbsr25 216 8 does do VBZ cord-024189-t7mbsr25 216 9 not not RB cord-024189-t7mbsr25 216 10 enter enter VB cord-024189-t7mbsr25 216 11 remissions remission NNS cord-024189-t7mbsr25 216 12 that that WDT cord-024189-t7mbsr25 216 13 are be VBP cord-024189-t7mbsr25 216 14 sustained sustain VBN cord-024189-t7mbsr25 216 15 indefi indefi NNP cord-024189-t7mbsr25 216 16 nitely nitely NN cord-024189-t7mbsr25 216 17 after after IN cord-024189-t7mbsr25 216 18 discontinuation discontinuation NN cord-024189-t7mbsr25 216 19 of of IN cord-024189-t7mbsr25 216 20 glucocorticoids glucocorticoid NNS cord-024189-t7mbsr25 216 21 . . . cord-024189-t7mbsr25 217 1 In in IN cord-024189-t7mbsr25 217 2 a a DT cord-024189-t7mbsr25 217 3 prospective prospective JJ cord-024189-t7mbsr25 217 4 study study NN cord-024189-t7mbsr25 217 5 of of IN cord-024189-t7mbsr25 217 6 25 25 CD cord-024189-t7mbsr25 217 7 patients patient NNS cord-024189-t7mbsr25 217 8 with with IN cord-024189-t7mbsr25 217 9 biopsyproven biopsyproven NNP cord-024189-t7mbsr25 217 10 GCA GCA NNP cord-024189-t7mbsr25 217 11 , , , cord-024189-t7mbsr25 217 12 all all DT cord-024189-t7mbsr25 217 13 of of IN cord-024189-t7mbsr25 217 14 the the DT cord-024189-t7mbsr25 217 15 patients patient NNS cord-024189-t7mbsr25 217 16 responded respond VBD cord-024189-t7mbsr25 217 17 to to IN cord-024189-t7mbsr25 217 18 60 60 CD cord-024189-t7mbsr25 217 19 mg mg NNP cord-024189-t7mbsr25 217 20 prednisone prednisone NN cord-024189-t7mbsr25 217 21 with with IN cord-024189-t7mbsr25 217 22 disappearance disappearance NN cord-024189-t7mbsr25 217 23 of of IN cord-024189-t7mbsr25 217 24 clinical clinical JJ cord-024189-t7mbsr25 217 25 signs sign NNS cord-024189-t7mbsr25 217 26 of of IN cord-024189-t7mbsr25 217 27 the the DT cord-024189-t7mbsr25 217 28 disease disease NN cord-024189-t7mbsr25 217 29 ( ( -LRB- cord-024189-t7mbsr25 217 30 16 16 CD cord-024189-t7mbsr25 217 31 ) ) -RRB- cord-024189-t7mbsr25 217 32 . . . cord-024189-t7mbsr25 218 1 However however RB cord-024189-t7mbsr25 218 2 , , , cord-024189-t7mbsr25 218 3 60 60 CD cord-024189-t7mbsr25 218 4 % % NN cord-024189-t7mbsr25 218 5 of of IN cord-024189-t7mbsr25 218 6 patients patient NNS cord-024189-t7mbsr25 218 7 had have VBD cord-024189-t7mbsr25 218 8 disease disease NN cord-024189-t7mbsr25 218 9 relapses relapse NNS cord-024189-t7mbsr25 218 10 that that WDT cord-024189-t7mbsr25 218 11 occurred occur VBD cord-024189-t7mbsr25 218 12 throughout throughout IN cord-024189-t7mbsr25 218 13 the the DT cord-024189-t7mbsr25 218 14 course course NN cord-024189-t7mbsr25 218 15 of of IN cord-024189-t7mbsr25 218 16 treatment treatment NN cord-024189-t7mbsr25 218 17 . . . cord-024189-t7mbsr25 219 1 Typically typically RB cord-024189-t7mbsr25 219 2 , , , cord-024189-t7mbsr25 219 3 reactivation reactivation NN cord-024189-t7mbsr25 219 4 of of IN cord-024189-t7mbsr25 219 5 the the DT cord-024189-t7mbsr25 219 6 disease disease NN cord-024189-t7mbsr25 219 7 produced produce VBD cord-024189-t7mbsr25 219 8 symptoms symptom NNS cord-024189-t7mbsr25 219 9 of of IN cord-024189-t7mbsr25 219 10 systemic systemic JJ cord-024189-t7mbsr25 219 11 infl infl NN cord-024189-t7mbsr25 219 12 ammation ammation NN cord-024189-t7mbsr25 219 13 or or CC cord-024189-t7mbsr25 219 14 polymyalgic polymyalgic JJ cord-024189-t7mbsr25 219 15 symptoms symptom NNS cord-024189-t7mbsr25 219 16 , , , cord-024189-t7mbsr25 219 17 but but CC cord-024189-t7mbsr25 219 18 no no DT cord-024189-t7mbsr25 219 19 vascular vascular JJ cord-024189-t7mbsr25 219 20 complications complication NNS cord-024189-t7mbsr25 219 21 were be VBD cord-024189-t7mbsr25 219 22 seen see VBN cord-024189-t7mbsr25 219 23 . . . cord-024189-t7mbsr25 220 1 Polymyalgia Polymyalgia NNP cord-024189-t7mbsr25 220 2 rheumatica rheumatica NNP cord-024189-t7mbsr25 220 3 is be VBZ cord-024189-t7mbsr25 220 4 diagnosed diagnose VBN cord-024189-t7mbsr25 220 5 in in IN cord-024189-t7mbsr25 220 6 patients patient NNS cord-024189-t7mbsr25 220 7 presenting present VBG cord-024189-t7mbsr25 220 8 with with IN cord-024189-t7mbsr25 220 9 pain pain NN cord-024189-t7mbsr25 220 10 and and CC cord-024189-t7mbsr25 220 11 stiffness stiffness NN cord-024189-t7mbsr25 220 12 in in IN cord-024189-t7mbsr25 220 13 the the DT cord-024189-t7mbsr25 220 14 muscles muscle NNS cord-024189-t7mbsr25 220 15 of of IN cord-024189-t7mbsr25 220 16 the the DT cord-024189-t7mbsr25 220 17 neck neck NN cord-024189-t7mbsr25 220 18 , , , cord-024189-t7mbsr25 220 19 shoulder shoulder NN cord-024189-t7mbsr25 220 20 girdle girdle NN cord-024189-t7mbsr25 220 21 , , , cord-024189-t7mbsr25 220 22 and and CC cord-024189-t7mbsr25 220 23 pelvic pelvic JJ cord-024189-t7mbsr25 220 24 girdle girdle NN cord-024189-t7mbsr25 220 25 of of IN cord-024189-t7mbsr25 220 26 at at RB cord-024189-t7mbsr25 220 27 least least JJS cord-024189-t7mbsr25 220 28 4 4 CD cord-024189-t7mbsr25 220 29 weeks week NNS cord-024189-t7mbsr25 220 30 ' ' POS cord-024189-t7mbsr25 220 31 duration duration NN cord-024189-t7mbsr25 220 32 ( ( -LRB- cord-024189-t7mbsr25 220 33 24 24 CD cord-024189-t7mbsr25 220 34 ) ) -RRB- cord-024189-t7mbsr25 220 35 . . . cord-024189-t7mbsr25 221 1 The the DT cord-024189-t7mbsr25 221 2 myalgias myalgia NNS cord-024189-t7mbsr25 221 3 are be VBP cord-024189-t7mbsr25 221 4 combined combine VBN cord-024189-t7mbsr25 221 5 with with IN cord-024189-t7mbsr25 221 6 signs sign NNS cord-024189-t7mbsr25 221 7 of of IN cord-024189-t7mbsr25 221 8 systemic systemic JJ cord-024189-t7mbsr25 221 9 infl infl NN cord-024189-t7mbsr25 221 10 ammation ammation NN cord-024189-t7mbsr25 221 11 manifesting manifest VBG cord-024189-t7mbsr25 221 12 clinically clinically RB cord-024189-t7mbsr25 221 13 as as IN cord-024189-t7mbsr25 221 14 malaise malaise NN cord-024189-t7mbsr25 221 15 , , , cord-024189-t7mbsr25 221 16 weight weight NN cord-024189-t7mbsr25 221 17 loss loss NN cord-024189-t7mbsr25 221 18 , , , cord-024189-t7mbsr25 221 19 sweats sweat NNS cord-024189-t7mbsr25 221 20 , , , cord-024189-t7mbsr25 221 21 and and CC cord-024189-t7mbsr25 221 22 low low JJ cord-024189-t7mbsr25 221 23 - - HYPH cord-024189-t7mbsr25 221 24 grade grade NN cord-024189-t7mbsr25 221 25 fever fever NN cord-024189-t7mbsr25 221 26 . . . cord-024189-t7mbsr25 222 1 Most Most JJS cord-024189-t7mbsr25 222 2 patients patient NNS cord-024189-t7mbsr25 222 3 have have VBP cord-024189-t7mbsr25 222 4 laboratory laboratory NN cord-024189-t7mbsr25 222 5 abnormalities abnormality NNS cord-024189-t7mbsr25 222 6 such such JJ cord-024189-t7mbsr25 222 7 as as IN cord-024189-t7mbsr25 222 8 elevated elevate VBN cord-024189-t7mbsr25 222 9 ESR ESR NNP cord-024189-t7mbsr25 222 10 , , , cord-024189-t7mbsr25 222 11 elevated elevated JJ cord-024189-t7mbsr25 222 12 CRP crp NN cord-024189-t7mbsr25 222 13 , , , cord-024189-t7mbsr25 222 14 and and CC cord-024189-t7mbsr25 222 15 anemia anemia NN cord-024189-t7mbsr25 222 16 , , , cord-024189-t7mbsr25 222 17 which which WDT cord-024189-t7mbsr25 222 18 are be VBP cord-024189-t7mbsr25 222 19 indicative indicative JJ cord-024189-t7mbsr25 222 20 of of IN cord-024189-t7mbsr25 222 21 a a DT cord-024189-t7mbsr25 222 22 systemic systemic JJ cord-024189-t7mbsr25 222 23 infl infl NNP cord-024189-t7mbsr25 222 24 ammatory ammatory NNP cord-024189-t7mbsr25 222 25 syndrome syndrome NN cord-024189-t7mbsr25 222 26 . . . cord-024189-t7mbsr25 223 1 Upregulation upregulation NN cord-024189-t7mbsr25 223 2 of of IN cord-024189-t7mbsr25 223 3 acute acute JJ cord-024189-t7mbsr25 223 4 phase phase NN cord-024189-t7mbsr25 223 5 reactants reactant NNS cord-024189-t7mbsr25 223 6 is be VBZ cord-024189-t7mbsr25 223 7 helpful helpful JJ cord-024189-t7mbsr25 223 8 in in IN cord-024189-t7mbsr25 223 9 distinguishing distinguish VBG cord-024189-t7mbsr25 223 10 PMR PMR NNP cord-024189-t7mbsr25 223 11 from from IN cord-024189-t7mbsr25 223 12 other other JJ cord-024189-t7mbsr25 223 13 pain pain NN cord-024189-t7mbsr25 223 14 syndromes syndrome NNS cord-024189-t7mbsr25 223 15 , , , cord-024189-t7mbsr25 223 16 yet yet CC cord-024189-t7mbsr25 223 17 ( ( -LRB- cord-024189-t7mbsr25 223 18 as as IN cord-024189-t7mbsr25 223 19 in in IN cord-024189-t7mbsr25 223 20 GCA GCA NNP cord-024189-t7mbsr25 223 21 and and CC cord-024189-t7mbsr25 223 22 TA TA NNP cord-024189-t7mbsr25 223 23 ) ) -RRB- cord-024189-t7mbsr25 223 24 not not RB cord-024189-t7mbsr25 223 25 all all DT cord-024189-t7mbsr25 223 26 patients patient NNS cord-024189-t7mbsr25 223 27 with with IN cord-024189-t7mbsr25 223 28 active active JJ cord-024189-t7mbsr25 223 29 disease disease NN cord-024189-t7mbsr25 223 30 have have VBP cord-024189-t7mbsr25 223 31 elevated elevated JJ cord-024189-t7mbsr25 223 32 markers marker NNS cord-024189-t7mbsr25 223 33 of of IN cord-024189-t7mbsr25 223 34 infl infl NN cord-024189-t7mbsr25 223 35 ammation ammation NN cord-024189-t7mbsr25 223 36 within within IN cord-024189-t7mbsr25 223 37 their -PRON- PRP$ cord-024189-t7mbsr25 223 38 serum serum NN cord-024189-t7mbsr25 223 39 . . . cord-024189-t7mbsr25 224 1 No no DT cord-024189-t7mbsr25 224 2 pathognomic pathognomic JJ cord-024189-t7mbsr25 224 3 test test NN cord-024189-t7mbsr25 224 4 for for IN cord-024189-t7mbsr25 224 5 PMR PMR NNP cord-024189-t7mbsr25 224 6 is be VBZ cord-024189-t7mbsr25 224 7 available available JJ cord-024189-t7mbsr25 224 8 ; ; : cord-024189-t7mbsr25 224 9 exclusion exclusion NN cord-024189-t7mbsr25 224 10 of of IN cord-024189-t7mbsr25 224 11 other other JJ cord-024189-t7mbsr25 224 12 diseases disease NNS cord-024189-t7mbsr25 224 13 with with IN cord-024189-t7mbsr25 224 14 similar similar JJ cord-024189-t7mbsr25 224 15 clinical clinical JJ cord-024189-t7mbsr25 224 16 presentations presentation NNS cord-024189-t7mbsr25 224 17 is be VBZ cord-024189-t7mbsr25 224 18 essential essential JJ cord-024189-t7mbsr25 224 19 . . . cord-024189-t7mbsr25 225 1 The the DT cord-024189-t7mbsr25 225 2 systemic systemic JJ cord-024189-t7mbsr25 225 3 infl infl NN cord-024189-t7mbsr25 225 4 ammatory ammatory NNP cord-024189-t7mbsr25 225 5 syndrome syndrome NN cord-024189-t7mbsr25 225 6 associated associate VBN cord-024189-t7mbsr25 225 7 with with IN cord-024189-t7mbsr25 225 8 PMR PMR NNP cord-024189-t7mbsr25 225 9 is be VBZ cord-024189-t7mbsr25 225 10 exquisitely exquisitely RB cord-024189-t7mbsr25 225 11 sensitive sensitive JJ cord-024189-t7mbsr25 225 12 to to IN cord-024189-t7mbsr25 225 13 glucocorticoid glucocorticoid NN cord-024189-t7mbsr25 225 14 therapy therapy NN cord-024189-t7mbsr25 225 15 , , , cord-024189-t7mbsr25 225 16 such such JJ cord-024189-t7mbsr25 225 17 that that IN cord-024189-t7mbsr25 225 18 prompt prompt JJ cord-024189-t7mbsr25 225 19 improvement improvement NN cord-024189-t7mbsr25 225 20 of of IN cord-024189-t7mbsr25 225 21 clinical clinical JJ cord-024189-t7mbsr25 225 22 symptoms symptom NNS cord-024189-t7mbsr25 225 23 with with IN cord-024189-t7mbsr25 225 24 glucocorticoid glucocorticoid NN cord-024189-t7mbsr25 225 25 therapy therapy NN cord-024189-t7mbsr25 225 26 has have VBZ cord-024189-t7mbsr25 225 27 been be VBN cord-024189-t7mbsr25 225 28 proposed propose VBN cord-024189-t7mbsr25 225 29 as as IN cord-024189-t7mbsr25 225 30 a a DT cord-024189-t7mbsr25 225 31 diagnostic diagnostic JJ cord-024189-t7mbsr25 225 32 criterion criterion NN cord-024189-t7mbsr25 225 33 . . . cord-024189-t7mbsr25 226 1 The the DT cord-024189-t7mbsr25 226 2 pathophysiology pathophysiology NN cord-024189-t7mbsr25 226 3 of of IN cord-024189-t7mbsr25 226 4 PMR PMR NNP cord-024189-t7mbsr25 226 5 is be VBZ cord-024189-t7mbsr25 226 6 related relate VBN cord-024189-t7mbsr25 226 7 closely closely RB cord-024189-t7mbsr25 226 8 to to IN cord-024189-t7mbsr25 226 9 those those DT cord-024189-t7mbsr25 226 10 of of IN cord-024189-t7mbsr25 226 11 GCA GCA NNP cord-024189-t7mbsr25 226 12 . . . cord-024189-t7mbsr25 227 1 PMR PMR NNP cord-024189-t7mbsr25 227 2 is be VBZ cord-024189-t7mbsr25 227 3 now now RB cord-024189-t7mbsr25 227 4 often often RB cord-024189-t7mbsr25 227 5 considered consider VBN cord-024189-t7mbsr25 227 6 a a DT cord-024189-t7mbsr25 227 7 form form NN cord-024189-t7mbsr25 227 8 of of IN cord-024189-t7mbsr25 227 9 GCA GCA NNP cord-024189-t7mbsr25 227 10 that that WDT cord-024189-t7mbsr25 227 11 lacks lack VBZ cord-024189-t7mbsr25 227 12 fully fully RB cord-024189-t7mbsr25 227 13 developed develop VBN cord-024189-t7mbsr25 227 14 vasculitis vasculitis NN cord-024189-t7mbsr25 227 15 . . . cord-024189-t7mbsr25 228 1 Because because IN cord-024189-t7mbsr25 228 2 PMR PMR NNP cord-024189-t7mbsr25 228 3 remains remain VBZ cord-024189-t7mbsr25 228 4 a a DT cord-024189-t7mbsr25 228 5 clinical clinical JJ cord-024189-t7mbsr25 228 6 diagnosis diagnosis NN cord-024189-t7mbsr25 228 7 , , , cord-024189-t7mbsr25 228 8 epidemiological epidemiological JJ cord-024189-t7mbsr25 228 9 studies study NNS cord-024189-t7mbsr25 228 10 are be VBP cord-024189-t7mbsr25 228 11 diffi diffi NNP cord-024189-t7mbsr25 228 12 cult cult NN cord-024189-t7mbsr25 228 13 . . . cord-024189-t7mbsr25 229 1 PMR PMR NNP cord-024189-t7mbsr25 229 2 affects affect VBZ cord-024189-t7mbsr25 229 3 the the DT cord-024189-t7mbsr25 229 4 same same JJ cord-024189-t7mbsr25 229 5 patient patient JJ cord-024189-t7mbsr25 229 6 population population NN cord-024189-t7mbsr25 229 7 as as IN cord-024189-t7mbsr25 229 8 GCA GCA NNP cord-024189-t7mbsr25 229 9 , , , cord-024189-t7mbsr25 229 10 but but CC cord-024189-t7mbsr25 229 11 occurs occur VBZ cord-024189-t7mbsr25 229 12 approximately approximately RB cord-024189-t7mbsr25 229 13 two two CD cord-024189-t7mbsr25 229 14 to to TO cord-024189-t7mbsr25 229 15 three three CD cord-024189-t7mbsr25 229 16 times time NNS cord-024189-t7mbsr25 229 17 more more RBR cord-024189-t7mbsr25 229 18 frequently frequently RB cord-024189-t7mbsr25 229 19 ( ( -LRB- cord-024189-t7mbsr25 229 20 24 24 CD cord-024189-t7mbsr25 229 21 ) ) -RRB- cord-024189-t7mbsr25 229 22 . . . cord-024189-t7mbsr25 230 1 Women woman NNS cord-024189-t7mbsr25 230 2 are be VBP cord-024189-t7mbsr25 230 3 affected affect VBN cord-024189-t7mbsr25 230 4 more more RBR cord-024189-t7mbsr25 230 5 often often RB cord-024189-t7mbsr25 230 6 than than IN cord-024189-t7mbsr25 230 7 men man NNS cord-024189-t7mbsr25 230 8 , , , cord-024189-t7mbsr25 230 9 and and CC cord-024189-t7mbsr25 230 10 the the DT cord-024189-t7mbsr25 230 11 diagnosis diagnosis NN cord-024189-t7mbsr25 230 12 is be VBZ cord-024189-t7mbsr25 230 13 extremely extremely RB cord-024189-t7mbsr25 230 14 unlikely unlikely JJ cord-024189-t7mbsr25 230 15 in in IN cord-024189-t7mbsr25 230 16 individuals individual NNS cord-024189-t7mbsr25 230 17 younger young JJR cord-024189-t7mbsr25 230 18 than than IN cord-024189-t7mbsr25 230 19 50 50 CD cord-024189-t7mbsr25 230 20 years year NNS cord-024189-t7mbsr25 230 21 of of IN cord-024189-t7mbsr25 230 22 age age NN cord-024189-t7mbsr25 230 23 . . . cord-024189-t7mbsr25 231 1 In in IN cord-024189-t7mbsr25 231 2 high high JJ cord-024189-t7mbsr25 231 3 - - HYPH cord-024189-t7mbsr25 231 4 risk risk NN cord-024189-t7mbsr25 231 5 populations population NNS cord-024189-t7mbsr25 231 6 , , , cord-024189-t7mbsr25 231 7 such such JJ cord-024189-t7mbsr25 231 8 as as IN cord-024189-t7mbsr25 231 9 Scandinavians Scandinavians NNPS cord-024189-t7mbsr25 231 10 and and CC cord-024189-t7mbsr25 231 11 other other JJ cord-024189-t7mbsr25 231 12 peoples people NNS cord-024189-t7mbsr25 231 13 of of IN cord-024189-t7mbsr25 231 14 Northern northern JJ cord-024189-t7mbsr25 231 15 European european JJ cord-024189-t7mbsr25 231 16 descent descent NN cord-024189-t7mbsr25 231 17 , , , cord-024189-t7mbsr25 231 18 annual annual JJ cord-024189-t7mbsr25 231 19 incidence incidence NN cord-024189-t7mbsr25 231 20 rates rate NNS cord-024189-t7mbsr25 231 21 have have VBP cord-024189-t7mbsr25 231 22 been be VBN cord-024189-t7mbsr25 231 23 estimated estimate VBN cord-024189-t7mbsr25 231 24 at at IN cord-024189-t7mbsr25 231 25 20 20 CD cord-024189-t7mbsr25 231 26 to to TO cord-024189-t7mbsr25 231 27 53 53 CD cord-024189-t7mbsr25 231 28 per per IN cord-024189-t7mbsr25 231 29 100,000 100,000 CD cord-024189-t7mbsr25 231 30 persons person NNS cord-024189-t7mbsr25 231 31 over over IN cord-024189-t7mbsr25 231 32 the the DT cord-024189-t7mbsr25 231 33 age age NN cord-024189-t7mbsr25 231 34 of of IN cord-024189-t7mbsr25 231 35 50 50 CD cord-024189-t7mbsr25 231 36 years year NNS cord-024189-t7mbsr25 231 37 . . . cord-024189-t7mbsr25 232 1 In in IN cord-024189-t7mbsr25 232 2 low low JJ cord-024189-t7mbsr25 232 3 - - HYPH cord-024189-t7mbsr25 232 4 risk risk NN cord-024189-t7mbsr25 232 5 populations population NNS cord-024189-t7mbsr25 232 6 , , , cord-024189-t7mbsr25 232 7 such such JJ cord-024189-t7mbsr25 232 8 as as IN cord-024189-t7mbsr25 232 9 Italians Italians NNPS cord-024189-t7mbsr25 232 10 , , , cord-024189-t7mbsr25 232 11 the the DT cord-024189-t7mbsr25 232 12 annual annual JJ cord-024189-t7mbsr25 232 13 incidence incidence NN cord-024189-t7mbsr25 232 14 rates rate NNS cord-024189-t7mbsr25 232 15 for for IN cord-024189-t7mbsr25 232 16 individuals individual NNS cord-024189-t7mbsr25 232 17 aged age VBN cord-024189-t7mbsr25 232 18 50 50 CD cord-024189-t7mbsr25 232 19 years year NNS cord-024189-t7mbsr25 232 20 and and CC cord-024189-t7mbsr25 232 21 older old JJR cord-024189-t7mbsr25 232 22 are be VBP cord-024189-t7mbsr25 232 23 only only RB cord-024189-t7mbsr25 232 24 10 10 CD cord-024189-t7mbsr25 232 25 cases case NNS cord-024189-t7mbsr25 232 26 per per IN cord-024189-t7mbsr25 232 27 100,000 100,000 CD cord-024189-t7mbsr25 232 28 . . . cord-024189-t7mbsr25 233 1 Although although IN cord-024189-t7mbsr25 233 2 the the DT cord-024189-t7mbsr25 233 3 sudden sudden JJ cord-024189-t7mbsr25 233 4 onset onset NN cord-024189-t7mbsr25 233 5 of of IN cord-024189-t7mbsr25 233 6 intense intense JJ cord-024189-t7mbsr25 233 7 infl infl NN cord-024189-t7mbsr25 233 8 ammation ammation NN cord-024189-t7mbsr25 233 9 is be VBZ cord-024189-t7mbsr25 233 10 suspicious suspicious JJ cord-024189-t7mbsr25 233 11 for for IN cord-024189-t7mbsr25 233 12 an an DT cord-024189-t7mbsr25 233 13 infectious infectious JJ cord-024189-t7mbsr25 233 14 etiology etiology NN cord-024189-t7mbsr25 233 15 , , , cord-024189-t7mbsr25 233 16 no no DT cord-024189-t7mbsr25 233 17 causative causative JJ cord-024189-t7mbsr25 233 18 agent agent NN cord-024189-t7mbsr25 233 19 has have VBZ cord-024189-t7mbsr25 233 20 been be VBN cord-024189-t7mbsr25 233 21 identifi identifi VBN cord-024189-t7mbsr25 233 22 ed ed NNP cord-024189-t7mbsr25 233 23 . . . cord-024189-t7mbsr25 234 1 Most Most JJS cord-024189-t7mbsr25 234 2 pathogenic pathogenic JJ cord-024189-t7mbsr25 234 3 abnormalities abnormality NNS cord-024189-t7mbsr25 234 4 in in IN cord-024189-t7mbsr25 234 5 PMR PMR NNP cord-024189-t7mbsr25 234 6 patients patient NNS cord-024189-t7mbsr25 234 7 are be VBP cord-024189-t7mbsr25 234 8 reminiscent reminiscent JJ cord-024189-t7mbsr25 234 9 of of IN cord-024189-t7mbsr25 234 10 those those DT cord-024189-t7mbsr25 234 11 in in IN cord-024189-t7mbsr25 234 12 GCA GCA NNP cord-024189-t7mbsr25 234 13 , , , cord-024189-t7mbsr25 234 14 supporting support VBG cord-024189-t7mbsr25 234 15 the the DT cord-024189-t7mbsr25 234 16 concept concept NN cord-024189-t7mbsr25 234 17 that that IN cord-024189-t7mbsr25 234 18 PMR PMR NNP cord-024189-t7mbsr25 234 19 is be VBZ cord-024189-t7mbsr25 234 20 a a DT cord-024189-t7mbsr25 234 21 variant variant NN cord-024189-t7mbsr25 234 22 of of IN cord-024189-t7mbsr25 234 23 GCA GCA NNP cord-024189-t7mbsr25 234 24 characterized characterize VBN cord-024189-t7mbsr25 234 25 by by IN cord-024189-t7mbsr25 234 26 the the DT cord-024189-t7mbsr25 234 27 dominance dominance NN cord-024189-t7mbsr25 234 28 of of IN cord-024189-t7mbsr25 234 29 the the DT cord-024189-t7mbsr25 234 30 systemic systemic JJ cord-024189-t7mbsr25 234 31 infl infl NN cord-024189-t7mbsr25 234 32 ammatory ammatory NN cord-024189-t7mbsr25 234 33 over over IN cord-024189-t7mbsr25 234 34 the the DT cord-024189-t7mbsr25 234 35 vascular vascular JJ cord-024189-t7mbsr25 234 36 component component NN cord-024189-t7mbsr25 234 37 . . . cord-024189-t7mbsr25 235 1 Human human JJ cord-024189-t7mbsr25 235 2 leukocyte leukocyte NN cord-024189-t7mbsr25 235 3 antigen antigen NN cord-024189-t7mbsr25 235 4 polymorphisms polymorphism NNS cord-024189-t7mbsr25 235 5 that that WDT cord-024189-t7mbsr25 235 6 are be VBP cord-024189-t7mbsr25 235 7 genetic genetic JJ cord-024189-t7mbsr25 235 8 risk risk NN cord-024189-t7mbsr25 235 9 factors factor NNS cord-024189-t7mbsr25 235 10 for for IN cord-024189-t7mbsr25 235 11 GCA GCA NNP cord-024189-t7mbsr25 235 12 are be VBP cord-024189-t7mbsr25 235 13 also also RB cord-024189-t7mbsr25 235 14 associated associate VBN cord-024189-t7mbsr25 235 15 with with IN cord-024189-t7mbsr25 235 16 PMR PMR NNP cord-024189-t7mbsr25 235 17 . . . cord-024189-t7mbsr25 236 1 There there EX cord-024189-t7mbsr25 236 2 is be VBZ cord-024189-t7mbsr25 236 3 no no DT cord-024189-t7mbsr25 236 4 evidence evidence NN cord-024189-t7mbsr25 236 5 that that IN cord-024189-t7mbsr25 236 6 the the DT cord-024189-t7mbsr25 236 7 HLA HLA NNP cord-024189-t7mbsr25 236 8 has have VBZ cord-024189-t7mbsr25 236 9 a a DT cord-024189-t7mbsr25 236 10 role role NN cord-024189-t7mbsr25 236 11 in in IN cord-024189-t7mbsr25 236 12 determining determine VBG cord-024189-t7mbsr25 236 13 whether whether IN cord-024189-t7mbsr25 236 14 the the DT cord-024189-t7mbsr25 236 15 disease disease NN cord-024189-t7mbsr25 236 16 process process NN cord-024189-t7mbsr25 236 17 will will MD cord-024189-t7mbsr25 236 18 remain remain VB cord-024189-t7mbsr25 236 19 limited limited JJ cord-024189-t7mbsr25 236 20 to to IN cord-024189-t7mbsr25 236 21 PMR PMR NNP cord-024189-t7mbsr25 236 22 or or CC cord-024189-t7mbsr25 236 23 progress progress NN cord-024189-t7mbsr25 236 24 to to TO cord-024189-t7mbsr25 236 25 fully fully RB cord-024189-t7mbsr25 236 26 developed develop VBN cord-024189-t7mbsr25 236 27 GCA GCA NNP cord-024189-t7mbsr25 236 28 . . . cord-024189-t7mbsr25 237 1 Polymyalgia Polymyalgia NNP cord-024189-t7mbsr25 237 2 rheumatica rheumatica NNP cord-024189-t7mbsr25 237 3 appears appear VBZ cord-024189-t7mbsr25 237 4 to to TO cord-024189-t7mbsr25 237 5 be be VB cord-024189-t7mbsr25 237 6 associated associate VBN cord-024189-t7mbsr25 237 7 with with IN cord-024189-t7mbsr25 237 8 a a DT cord-024189-t7mbsr25 237 9 global global JJ cord-024189-t7mbsr25 237 10 activation activation NN cord-024189-t7mbsr25 237 11 of of IN cord-024189-t7mbsr25 237 12 the the DT cord-024189-t7mbsr25 237 13 innate innate JJ cord-024189-t7mbsr25 237 14 immune immune JJ cord-024189-t7mbsr25 237 15 system system NN cord-024189-t7mbsr25 237 16 , , , cord-024189-t7mbsr25 237 17 including include VBG cord-024189-t7mbsr25 237 18 circulating circulate VBG cord-024189-t7mbsr25 237 19 monocytes monocyte NNS cord-024189-t7mbsr25 237 20 that that WDT cord-024189-t7mbsr25 237 21 produce produce VBP cord-024189-t7mbsr25 237 22 IL-1 IL-1 NNP cord-024189-t7mbsr25 237 23 and and CC cord-024189-t7mbsr25 237 24 IL-6 IL-6 NNP cord-024189-t7mbsr25 237 25 . . . cord-024189-t7mbsr25 238 1 Activated activate VBN cord-024189-t7mbsr25 238 2 DCs dc NNS cord-024189-t7mbsr25 238 3 render render VBP cord-024189-t7mbsr25 238 4 arteries artery NNS cord-024189-t7mbsr25 238 5 susceptible susceptible JJ cord-024189-t7mbsr25 238 6 to to IN cord-024189-t7mbsr25 238 7 vasculitis vasculitis NN cord-024189-t7mbsr25 238 8 . . . cord-024189-t7mbsr25 239 1 In in IN cord-024189-t7mbsr25 239 2 many many JJ cord-024189-t7mbsr25 239 3 patients patient NNS cord-024189-t7mbsr25 239 4 with with IN cord-024189-t7mbsr25 239 5 PMR PMR NNP cord-024189-t7mbsr25 239 6 , , , cord-024189-t7mbsr25 239 7 in in IN cord-024189-t7mbsr25 239 8 situ situ JJ cord-024189-t7mbsr25 239 9 cytokine cytokine NN cord-024189-t7mbsr25 239 10 production production NN cord-024189-t7mbsr25 239 11 can can MD cord-024189-t7mbsr25 239 12 be be VB cord-024189-t7mbsr25 239 13 demonstrated demonstrate VBN cord-024189-t7mbsr25 239 14 in in IN cord-024189-t7mbsr25 239 15 biopsy biopsy NN cord-024189-t7mbsr25 239 16 specimens specimen NNS cord-024189-t7mbsr25 239 17 , , , cord-024189-t7mbsr25 239 18 although although IN cord-024189-t7mbsr25 239 19 in in IN cord-024189-t7mbsr25 239 20 lower low JJR cord-024189-t7mbsr25 239 21 quantities quantity NNS cord-024189-t7mbsr25 239 22 than than IN cord-024189-t7mbsr25 239 23 in in IN cord-024189-t7mbsr25 239 24 GCA GCA NNP cord-024189-t7mbsr25 239 25 . . . cord-024189-t7mbsr25 240 1 Of of IN cord-024189-t7mbsr25 240 2 note note NN cord-024189-t7mbsr25 240 3 , , , cord-024189-t7mbsr25 240 4 IFNgamma IFNgamma NNP cord-024189-t7mbsr25 240 5 is be VBZ cord-024189-t7mbsr25 240 6 absent absent JJ cord-024189-t7mbsr25 240 7 in in IN cord-024189-t7mbsr25 240 8 PMR PMR NNP cord-024189-t7mbsr25 240 9 , , , cord-024189-t7mbsr25 240 10 but but CC cord-024189-t7mbsr25 240 11 abundant abundant JJ cord-024189-t7mbsr25 240 12 in in IN cord-024189-t7mbsr25 240 13 GCA GCA NNP cord-024189-t7mbsr25 240 14 ( ( -LRB- cord-024189-t7mbsr25 240 15 25 25 CD cord-024189-t7mbsr25 240 16 ) ) -RRB- cord-024189-t7mbsr25 240 17 . . . cord-024189-t7mbsr25 241 1 A a DT cord-024189-t7mbsr25 241 2 subset subset NN cord-024189-t7mbsr25 241 3 of of IN cord-024189-t7mbsr25 241 4 PMR PMR NNP cord-024189-t7mbsr25 241 5 patients patient NNS cord-024189-t7mbsr25 241 6 develops develop VBZ cord-024189-t7mbsr25 241 7 infl infl NNP cord-024189-t7mbsr25 241 8 ammation ammation NN cord-024189-t7mbsr25 241 9 of of IN cord-024189-t7mbsr25 241 10 periarticular periarticular JJ cord-024189-t7mbsr25 241 11 structures structure NNS cord-024189-t7mbsr25 241 12 , , , cord-024189-t7mbsr25 241 13 for for IN cord-024189-t7mbsr25 241 14 example example NN cord-024189-t7mbsr25 241 15 , , , cord-024189-t7mbsr25 241 16 bursae bursae NNP cord-024189-t7mbsr25 241 17 . . . cord-024189-t7mbsr25 242 1 Whether whether IN cord-024189-t7mbsr25 242 2 these these DT cord-024189-t7mbsr25 242 3 patients patient NNS cord-024189-t7mbsr25 242 4 comprise comprise VBP cord-024189-t7mbsr25 242 5 a a DT cord-024189-t7mbsr25 242 6 different different JJ cord-024189-t7mbsr25 242 7 subset subset VBN cord-024189-t7mbsr25 242 8 from from IN cord-024189-t7mbsr25 242 9 those those DT cord-024189-t7mbsr25 242 10 susceptible susceptible JJ cord-024189-t7mbsr25 242 11 to to IN cord-024189-t7mbsr25 242 12 developing develop VBG cord-024189-t7mbsr25 242 13 frank frank JJ cord-024189-t7mbsr25 242 14 vasculitis vasculitis NN cord-024189-t7mbsr25 242 15 remains remain VBZ cord-024189-t7mbsr25 242 16 unclear unclear JJ cord-024189-t7mbsr25 242 17 . . . cord-024189-t7mbsr25 243 1 Patients patient NNS cord-024189-t7mbsr25 243 2 complain complain VBP cord-024189-t7mbsr25 243 3 about about IN cord-024189-t7mbsr25 243 4 aching ache VBG cord-024189-t7mbsr25 243 5 and and CC cord-024189-t7mbsr25 243 6 pain pain NN cord-024189-t7mbsr25 243 7 in in IN cord-024189-t7mbsr25 243 8 the the DT cord-024189-t7mbsr25 243 9 muscles muscle NNS cord-024189-t7mbsr25 243 10 of of IN cord-024189-t7mbsr25 243 11 the the DT cord-024189-t7mbsr25 243 12 neck neck NN cord-024189-t7mbsr25 243 13 , , , cord-024189-t7mbsr25 243 14 shoulders shoulder NNS cord-024189-t7mbsr25 243 15 , , , cord-024189-t7mbsr25 243 16 lower lower VB cord-024189-t7mbsr25 243 17 back back RB cord-024189-t7mbsr25 243 18 , , , cord-024189-t7mbsr25 243 19 hips hip NNS cord-024189-t7mbsr25 243 20 , , , cord-024189-t7mbsr25 243 21 thighs thigh NNS cord-024189-t7mbsr25 243 22 , , , cord-024189-t7mbsr25 243 23 and and CC cord-024189-t7mbsr25 243 24 occasionally occasionally RB cord-024189-t7mbsr25 243 25 the the DT cord-024189-t7mbsr25 243 26 trunk trunk NN cord-024189-t7mbsr25 243 27 . . . cord-024189-t7mbsr25 244 1 In in IN cord-024189-t7mbsr25 244 2 typical typical JJ cord-024189-t7mbsr25 244 3 cases case NNS cord-024189-t7mbsr25 244 4 , , , cord-024189-t7mbsr25 244 5 the the DT cord-024189-t7mbsr25 244 6 onset onset NN cord-024189-t7mbsr25 244 7 is be VBZ cord-024189-t7mbsr25 244 8 abrupt abrupt JJ cord-024189-t7mbsr25 244 9 and and CC cord-024189-t7mbsr25 244 10 the the DT cord-024189-t7mbsr25 244 11 myalgias myalgia NNS cord-024189-t7mbsr25 244 12 symmetrical symmetrical RB cord-024189-t7mbsr25 244 13 ; ; : cord-024189-t7mbsr25 244 14 they -PRON- PRP cord-024189-t7mbsr25 244 15 usually usually RB cord-024189-t7mbsr25 244 16 affect affect VBP cord-024189-t7mbsr25 244 17 the the DT cord-024189-t7mbsr25 244 18 shoulders shoulder NNS cord-024189-t7mbsr25 244 19 fi fi NN cord-024189-t7mbsr25 244 20 rst rst NNP cord-024189-t7mbsr25 244 21 . . . cord-024189-t7mbsr25 245 1 Often often RB cord-024189-t7mbsr25 245 2 the the DT cord-024189-t7mbsr25 245 3 patients patient NNS cord-024189-t7mbsr25 245 4 have have VBP cord-024189-t7mbsr25 245 5 pain pain NN cord-024189-t7mbsr25 245 6 during during IN cord-024189-t7mbsr25 245 7 the the DT cord-024189-t7mbsr25 245 8 night night NN cord-024189-t7mbsr25 245 9 and and CC cord-024189-t7mbsr25 245 10 have have VBP cord-024189-t7mbsr25 245 11 diffi diffi NNP cord-024189-t7mbsr25 245 12 culties cultie NNS cord-024189-t7mbsr25 245 13 rising rise VBG cord-024189-t7mbsr25 245 14 and and CC cord-024189-t7mbsr25 245 15 dressing dress VBG cord-024189-t7mbsr25 245 16 themselves -PRON- PRP cord-024189-t7mbsr25 245 17 . . . cord-024189-t7mbsr25 246 1 Weight weight NN cord-024189-t7mbsr25 246 2 loss loss NN cord-024189-t7mbsr25 246 3 , , , cord-024189-t7mbsr25 246 4 anorexia anorexia NN cord-024189-t7mbsr25 246 5 , , , cord-024189-t7mbsr25 246 6 malaise malaise NN cord-024189-t7mbsr25 246 7 , , , cord-024189-t7mbsr25 246 8 and and CC cord-024189-t7mbsr25 246 9 depression depression NN cord-024189-t7mbsr25 246 10 are be VBP cord-024189-t7mbsr25 246 11 common common JJ cord-024189-t7mbsr25 246 12 . . . cord-024189-t7mbsr25 247 1 Fever fever NN cord-024189-t7mbsr25 247 2 and and CC cord-024189-t7mbsr25 247 3 chills chill NNS cord-024189-t7mbsr25 247 4 should should MD cord-024189-t7mbsr25 247 5 raise raise VB cord-024189-t7mbsr25 247 6 the the DT cord-024189-t7mbsr25 247 7 suspicion suspicion NN cord-024189-t7mbsr25 247 8 of of IN cord-024189-t7mbsr25 247 9 fully fully RB cord-024189-t7mbsr25 247 10 developed develop VBN cord-024189-t7mbsr25 247 11 GCA GCA NNP cord-024189-t7mbsr25 247 12 . . . cord-024189-t7mbsr25 248 1 PMR PMR NNP cord-024189-t7mbsr25 248 2 is be VBZ cord-024189-t7mbsr25 248 3 frequently frequently RB cord-024189-t7mbsr25 248 4 diffi diffi JJ cord-024189-t7mbsr25 248 5 cult cult NN cord-024189-t7mbsr25 248 6 to to TO cord-024189-t7mbsr25 248 7 distinguish distinguish VB cord-024189-t7mbsr25 248 8 from from IN cord-024189-t7mbsr25 248 9 forms form NNS cord-024189-t7mbsr25 248 10 of of IN cord-024189-t7mbsr25 248 11 seronegative seronegative JJ cord-024189-t7mbsr25 248 12 polyarthritis polyarthritis NN cord-024189-t7mbsr25 248 13 . . . cord-024189-t7mbsr25 249 1 In in IN cord-024189-t7mbsr25 249 2 particular particular JJ cord-024189-t7mbsr25 249 3 , , , cord-024189-t7mbsr25 249 4 male male JJ cord-024189-t7mbsr25 249 5 patients patient NNS cord-024189-t7mbsr25 249 6 can can MD cord-024189-t7mbsr25 249 7 present present VB cord-024189-t7mbsr25 249 8 with with IN cord-024189-t7mbsr25 249 9 proximal proximal JJ cord-024189-t7mbsr25 249 10 aching aching NN cord-024189-t7mbsr25 249 11 and and CC cord-024189-t7mbsr25 249 12 diffuse diffuse JJ cord-024189-t7mbsr25 249 13 edema edema NN cord-024189-t7mbsr25 249 14 of of IN cord-024189-t7mbsr25 249 15 the the DT cord-024189-t7mbsr25 249 16 hands hand NNS cord-024189-t7mbsr25 249 17 and and CC cord-024189-t7mbsr25 249 18 feet foot NNS cord-024189-t7mbsr25 249 19 that that WDT cord-024189-t7mbsr25 249 20 is be VBZ cord-024189-t7mbsr25 249 21 highly highly RB cord-024189-t7mbsr25 249 22 glucocorticoid glucocorticoid JJ cord-024189-t7mbsr25 249 23 - - HYPH cord-024189-t7mbsr25 249 24 responsive responsive JJ cord-024189-t7mbsr25 249 25 . . . cord-024189-t7mbsr25 250 1 Polymyalgia Polymyalgia NNP cord-024189-t7mbsr25 250 2 rheumatica rheumatica NNP cord-024189-t7mbsr25 250 3 includes include VBZ cord-024189-t7mbsr25 250 4 patients patient NNS cord-024189-t7mbsr25 250 5 with with IN cord-024189-t7mbsr25 250 6 mild mild JJ cord-024189-t7mbsr25 250 7 disease disease NN cord-024189-t7mbsr25 250 8 that that WDT cord-024189-t7mbsr25 250 9 is be VBZ cord-024189-t7mbsr25 250 10 promptly promptly RB cord-024189-t7mbsr25 250 11 responsive responsive JJ cord-024189-t7mbsr25 250 12 to to IN cord-024189-t7mbsr25 250 13 therapy therapy NN cord-024189-t7mbsr25 250 14 and and CC cord-024189-t7mbsr25 250 15 remits remit VBZ cord-024189-t7mbsr25 250 16 within within IN cord-024189-t7mbsr25 250 17 a a DT cord-024189-t7mbsr25 250 18 few few JJ cord-024189-t7mbsr25 250 19 months month NNS cord-024189-t7mbsr25 250 20 ( ( -LRB- cord-024189-t7mbsr25 250 21 26 26 CD cord-024189-t7mbsr25 250 22 ) ) -RRB- cord-024189-t7mbsr25 250 23 . . . cord-024189-t7mbsr25 251 1 In in IN cord-024189-t7mbsr25 251 2 many many JJ cord-024189-t7mbsr25 251 3 patients patient NNS cord-024189-t7mbsr25 251 4 , , , cord-024189-t7mbsr25 251 5 however however RB cord-024189-t7mbsr25 251 6 , , , cord-024189-t7mbsr25 251 7 reactivation reactivation NN cord-024189-t7mbsr25 251 8 of of IN cord-024189-t7mbsr25 251 9 myalgias myalgias NNP cord-024189-t7mbsr25 251 10 occurs occur VBZ cord-024189-t7mbsr25 251 11 when when WRB cord-024189-t7mbsr25 251 12 glucocorticoid glucocorticoid JJ cord-024189-t7mbsr25 251 13 doses dose NNS cord-024189-t7mbsr25 251 14 are be VBP cord-024189-t7mbsr25 251 15 tapered tapered JJ cord-024189-t7mbsr25 251 16 . . . cord-024189-t7mbsr25 252 1 Some some DT cord-024189-t7mbsr25 252 2 patients patient NNS cord-024189-t7mbsr25 252 3 require require VBP cord-024189-t7mbsr25 252 4 higher high JJR cord-024189-t7mbsr25 252 5 initial initial JJ cord-024189-t7mbsr25 252 6 doses dose NNS cord-024189-t7mbsr25 252 7 of of IN cord-024189-t7mbsr25 252 8 glucocorticoids glucocorticoid NNS cord-024189-t7mbsr25 252 9 than than IN cord-024189-t7mbsr25 252 10 are be VBP cord-024189-t7mbsr25 252 11 usually usually RB cord-024189-t7mbsr25 252 12 considered consider VBN cord-024189-t7mbsr25 252 13 to to TO cord-024189-t7mbsr25 252 14 be be VB cord-024189-t7mbsr25 252 15 effective effective JJ cord-024189-t7mbsr25 252 16 in in IN cord-024189-t7mbsr25 252 17 PMR PMR NNP cord-024189-t7mbsr25 252 18 . . . cord-024189-t7mbsr25 253 1 Patients patient NNS cord-024189-t7mbsr25 253 2 with with IN cord-024189-t7mbsr25 253 3 PMR PMR NNP cord-024189-t7mbsr25 253 4 must must MD cord-024189-t7mbsr25 253 5 be be VB cord-024189-t7mbsr25 253 6 carefully carefully RB cord-024189-t7mbsr25 253 7 evaluated evaluate VBN cord-024189-t7mbsr25 253 8 for for IN cord-024189-t7mbsr25 253 9 possible possible JJ cord-024189-t7mbsr25 253 10 GCA GCA NNP cord-024189-t7mbsr25 253 11 . . . cord-024189-t7mbsr25 254 1 A a DT cord-024189-t7mbsr25 254 2 negative negative JJ cord-024189-t7mbsr25 254 3 temporal temporal JJ cord-024189-t7mbsr25 254 4 artery artery NN cord-024189-t7mbsr25 254 5 biopsy biopsy NN cord-024189-t7mbsr25 254 6 does do VBZ cord-024189-t7mbsr25 254 7 not not RB cord-024189-t7mbsr25 254 8 exclude exclude VB cord-024189-t7mbsr25 254 9 the the DT cord-024189-t7mbsr25 254 10 possibility possibility NN cord-024189-t7mbsr25 254 11 of of IN cord-024189-t7mbsr25 254 12 large large JJ cord-024189-t7mbsr25 254 13 vessel vessel NN cord-024189-t7mbsr25 254 14 vasculitis vasculitis NN cord-024189-t7mbsr25 254 15 targeting target VBG cord-024189-t7mbsr25 254 16 primarily primarily RB cord-024189-t7mbsr25 254 17 the the DT cord-024189-t7mbsr25 254 18 subclavian subclavian JJ cord-024189-t7mbsr25 254 19 and and CC cord-024189-t7mbsr25 254 20 axillary axillary JJ cord-024189-t7mbsr25 254 21 arteries artery NNS cord-024189-t7mbsr25 254 22 and and CC cord-024189-t7mbsr25 254 23 the the DT cord-024189-t7mbsr25 254 24 aorta aorta NN cord-024189-t7mbsr25 254 25 . . . cord-024189-t7mbsr25 255 1 Signs sign NNS cord-024189-t7mbsr25 255 2 of of IN cord-024189-t7mbsr25 255 3 vascular vascular JJ cord-024189-t7mbsr25 255 4 insuffi insuffi NN cord-024189-t7mbsr25 255 5 ciency ciency NN cord-024189-t7mbsr25 255 6 , , , cord-024189-t7mbsr25 255 7 including include VBG cord-024189-t7mbsr25 255 8 claudication claudication NN cord-024189-t7mbsr25 255 9 in in IN cord-024189-t7mbsr25 255 10 the the DT cord-024189-t7mbsr25 255 11 extremities extremity NNS cord-024189-t7mbsr25 255 12 , , , cord-024189-t7mbsr25 255 13 bruits bruit NNS cord-024189-t7mbsr25 255 14 over over IN cord-024189-t7mbsr25 255 15 arteries artery NNS cord-024189-t7mbsr25 255 16 , , , cord-024189-t7mbsr25 255 17 and and CC cord-024189-t7mbsr25 255 18 discrepant discrepant JJ cord-024189-t7mbsr25 255 19 blood blood NN cord-024189-t7mbsr25 255 20 pressure pressure NN cord-024189-t7mbsr25 255 21 readings reading NNS cord-024189-t7mbsr25 255 22 should should MD cord-024189-t7mbsr25 255 23 alert alert VB cord-024189-t7mbsr25 255 24 the the DT cord-024189-t7mbsr25 255 25 physician physician NN cord-024189-t7mbsr25 255 26 to to IN cord-024189-t7mbsr25 255 27 the the DT cord-024189-t7mbsr25 255 28 possibility possibility NN cord-024189-t7mbsr25 255 29 of of IN cord-024189-t7mbsr25 255 30 GCA GCA NNP cord-024189-t7mbsr25 255 31 ( ( -LRB- cord-024189-t7mbsr25 255 32 12 12 CD cord-024189-t7mbsr25 255 33 ) ) -RRB- cord-024189-t7mbsr25 255 34 . . . cord-024189-t7mbsr25 256 1 MRA MRA NNP cord-024189-t7mbsr25 256 2 can can MD cord-024189-t7mbsr25 256 3 be be VB cord-024189-t7mbsr25 256 4 helpful helpful JJ cord-024189-t7mbsr25 256 5 in in IN cord-024189-t7mbsr25 256 6 confi confi NNP cord-024189-t7mbsr25 256 7 rming rme VBG cord-024189-t7mbsr25 256 8 the the DT cord-024189-t7mbsr25 256 9 concomitant concomitant JJ cord-024189-t7mbsr25 256 10 diagnosis diagnosis NN cord-024189-t7mbsr25 256 11 of of IN cord-024189-t7mbsr25 256 12 large large JJ cord-024189-t7mbsr25 256 13 vessel vessel NN cord-024189-t7mbsr25 256 14 vasculitis vasculitis NN cord-024189-t7mbsr25 256 15 . . . cord-024189-t7mbsr25 257 1 In in IN cord-024189-t7mbsr25 257 2 PMR PMR NNP cord-024189-t7mbsr25 257 3 patients patient NNS cord-024189-t7mbsr25 257 4 with with IN cord-024189-t7mbsr25 257 5 infl infl NN cord-024189-t7mbsr25 257 6 ammation ammation NN cord-024189-t7mbsr25 257 7 of of IN cord-024189-t7mbsr25 257 8 periarticular periarticular JJ cord-024189-t7mbsr25 257 9 structures structure NNS cord-024189-t7mbsr25 257 10 , , , cord-024189-t7mbsr25 257 11 the the DT cord-024189-t7mbsr25 257 12 most most RBS cord-024189-t7mbsr25 257 13 prominent prominent JJ cord-024189-t7mbsr25 257 14 fi fi NN cord-024189-t7mbsr25 257 15 ndings nding NNS cord-024189-t7mbsr25 257 16 are be VBP cord-024189-t7mbsr25 257 17 subdeltoid subdeltoid NNP cord-024189-t7mbsr25 257 18 and and CC cord-024189-t7mbsr25 257 19 subacromial subacromial JJ cord-024189-t7mbsr25 257 20 bursitis bursitis NN cord-024189-t7mbsr25 257 21 ( ( -LRB- cord-024189-t7mbsr25 257 22 27 27 CD cord-024189-t7mbsr25 257 23 ) ) -RRB- cord-024189-t7mbsr25 257 24 . . . cord-024189-t7mbsr25 258 1 Biceps biceps NN cord-024189-t7mbsr25 258 2 tendonitis tendonitis NN cord-024189-t7mbsr25 258 3 and and CC cord-024189-t7mbsr25 258 4 glenohumeral glenohumeral JJ cord-024189-t7mbsr25 258 5 synovitis synovitis NN cord-024189-t7mbsr25 258 6 may may MD cord-024189-t7mbsr25 258 7 also also RB cord-024189-t7mbsr25 258 8 be be VB cord-024189-t7mbsr25 258 9 present present JJ cord-024189-t7mbsr25 258 10 . . . cord-024189-t7mbsr25 259 1 Ultrasonography Ultrasonography NNP cord-024189-t7mbsr25 259 2 reveals reveal VBZ cord-024189-t7mbsr25 259 3 fl fl NNP cord-024189-t7mbsr25 259 4 uid uid NN cord-024189-t7mbsr25 259 5 accumulation accumulation NN cord-024189-t7mbsr25 259 6 in in IN cord-024189-t7mbsr25 259 7 the the DT cord-024189-t7mbsr25 259 8 bursae bursae NN cord-024189-t7mbsr25 259 9 ; ; , cord-024189-t7mbsr25 259 10 T2-weighted t2-weighte VBD cord-024189-t7mbsr25 259 11 MRI MRI NNP cord-024189-t7mbsr25 259 12 shows show VBZ cord-024189-t7mbsr25 259 13 thickening thickening NN cord-024189-t7mbsr25 259 14 and and CC cord-024189-t7mbsr25 259 15 edema edema NN cord-024189-t7mbsr25 259 16 . . . cord-024189-t7mbsr25 260 1 These these DT cord-024189-t7mbsr25 260 2 involved involve VBN cord-024189-t7mbsr25 260 3 areas area NNS cord-024189-t7mbsr25 260 4 show show VBP cord-024189-t7mbsr25 260 5 increased increase VBN cord-024189-t7mbsr25 260 6 uptake uptake NN cord-024189-t7mbsr25 260 7 on on IN cord-024189-t7mbsr25 260 8 PET pet NN cord-024189-t7mbsr25 260 9 scans scan NNS cord-024189-t7mbsr25 260 10 . . . cord-024189-t7mbsr25 261 1 The the DT cord-024189-t7mbsr25 261 2 clinical clinical JJ cord-024189-t7mbsr25 261 3 symptoms symptom NNS cord-024189-t7mbsr25 261 4 of of IN cord-024189-t7mbsr25 261 5 PMR PMR NNP cord-024189-t7mbsr25 261 6 can can MD cord-024189-t7mbsr25 261 7 be be VB cord-024189-t7mbsr25 261 8 mimicked mimic VBN cord-024189-t7mbsr25 261 9 by by IN cord-024189-t7mbsr25 261 10 a a DT cord-024189-t7mbsr25 261 11 number number NN cord-024189-t7mbsr25 261 12 of of IN cord-024189-t7mbsr25 261 13 arthropathies arthropathy NNS cord-024189-t7mbsr25 261 14 , , , cord-024189-t7mbsr25 261 15 shoulder shoulder NN cord-024189-t7mbsr25 261 16 disorders disorder NNS cord-024189-t7mbsr25 261 17 , , , cord-024189-t7mbsr25 261 18 infl infl NNP cord-024189-t7mbsr25 261 19 ammatory ammatory NNP cord-024189-t7mbsr25 261 20 myopathies myopathies NNP cord-024189-t7mbsr25 261 21 , , , cord-024189-t7mbsr25 261 22 hypothyroidism hypothyroidism NN cord-024189-t7mbsr25 261 23 , , , cord-024189-t7mbsr25 261 24 and and CC cord-024189-t7mbsr25 261 25 Parkinson Parkinson NNP cord-024189-t7mbsr25 261 26 's 's POS cord-024189-t7mbsr25 261 27 disease disease NN cord-024189-t7mbsr25 261 28 . . . cord-024189-t7mbsr25 262 1 The the DT cord-024189-t7mbsr25 262 2 differential differential JJ cord-024189-t7mbsr25 262 3 diagnosis diagnosis NN cord-024189-t7mbsr25 262 4 also also RB cord-024189-t7mbsr25 262 5 includes include VBZ cord-024189-t7mbsr25 262 6 malignancies malignancy NNS cord-024189-t7mbsr25 262 7 and and CC cord-024189-t7mbsr25 262 8 infections infection NNS cord-024189-t7mbsr25 262 9 . . . cord-024189-t7mbsr25 263 1 No no DT cord-024189-t7mbsr25 263 2 clear clear JJ cord-024189-t7mbsr25 263 3 guidelines guideline NNS cord-024189-t7mbsr25 263 4 have have VBP cord-024189-t7mbsr25 263 5 been be VBN cord-024189-t7mbsr25 263 6 developed develop VBN cord-024189-t7mbsr25 263 7 to to TO cord-024189-t7mbsr25 263 8 determine determine VB cord-024189-t7mbsr25 263 9 whether whether IN cord-024189-t7mbsr25 263 10 patients patient NNS cord-024189-t7mbsr25 263 11 with with IN cord-024189-t7mbsr25 263 12 PMR PMR NNP cord-024189-t7mbsr25 263 13 should should MD cord-024189-t7mbsr25 263 14 be be VB cord-024189-t7mbsr25 263 15 screened screen VBN cord-024189-t7mbsr25 263 16 for for IN cord-024189-t7mbsr25 263 17 occult occult JJ cord-024189-t7mbsr25 263 18 malignancies malignancy NNS cord-024189-t7mbsr25 263 19 . . . cord-024189-t7mbsr25 264 1 Lack lack NN cord-024189-t7mbsr25 264 2 of of IN cord-024189-t7mbsr25 264 3 the the DT cord-024189-t7mbsr25 264 4 typical typical JJ cord-024189-t7mbsr25 264 5 and and CC cord-024189-t7mbsr25 264 6 impressive impressive JJ cord-024189-t7mbsr25 264 7 improvement improvement NN cord-024189-t7mbsr25 264 8 upon upon IN cord-024189-t7mbsr25 264 9 initiation initiation NN cord-024189-t7mbsr25 264 10 of of IN cord-024189-t7mbsr25 264 11 therapy therapy NN cord-024189-t7mbsr25 264 12 can can MD cord-024189-t7mbsr25 264 13 provide provide VB cord-024189-t7mbsr25 264 14 a a DT cord-024189-t7mbsr25 264 15 clue clue NN cord-024189-t7mbsr25 264 16 towards towards IN cord-024189-t7mbsr25 264 17 reevaluating reevaluate VBG cord-024189-t7mbsr25 264 18 the the DT cord-024189-t7mbsr25 264 19 diagnosis diagnosis NN cord-024189-t7mbsr25 264 20 of of IN cord-024189-t7mbsr25 264 21 PMR PMR NNP cord-024189-t7mbsr25 264 22 . . . cord-024189-t7mbsr25 265 1 Polymyalgia Polymyalgia NNP cord-024189-t7mbsr25 265 2 rheumatica rheumatica NNP cord-024189-t7mbsr25 265 3 is be VBZ cord-024189-t7mbsr25 265 4 dramatically dramatically RB cord-024189-t7mbsr25 265 5 responsive responsive JJ cord-024189-t7mbsr25 265 6 to to IN cord-024189-t7mbsr25 265 7 glucocorticoid glucocorticoid NN cord-024189-t7mbsr25 265 8 therapy therapy NN cord-024189-t7mbsr25 265 9 . . . cord-024189-t7mbsr25 266 1 Currently currently RB cord-024189-t7mbsr25 266 2 there there EX cord-024189-t7mbsr25 266 3 are be VBP cord-024189-t7mbsr25 266 4 no no DT cord-024189-t7mbsr25 266 5 data data NN cord-024189-t7mbsr25 266 6 documenting document VBG cord-024189-t7mbsr25 266 7 glucocorticoid glucocorticoid NN cord-024189-t7mbsr25 266 8 - - HYPH cord-024189-t7mbsr25 266 9 sparing spare VBG cord-024189-t7mbsr25 266 10 effects effect NNS cord-024189-t7mbsr25 266 11 of of IN cord-024189-t7mbsr25 266 12 other other JJ cord-024189-t7mbsr25 266 13 medications medication NNS cord-024189-t7mbsr25 266 14 . . . cord-024189-t7mbsr25 267 1 However however RB cord-024189-t7mbsr25 267 2 , , , cord-024189-t7mbsr25 267 3 almost almost RB cord-024189-t7mbsr25 267 4 all all DT cord-024189-t7mbsr25 267 5 patients patient NNS cord-024189-t7mbsr25 267 6 with with IN cord-024189-t7mbsr25 267 7 PMR PMR NNP cord-024189-t7mbsr25 267 8 can can MD cord-024189-t7mbsr25 267 9 be be VB cord-024189-t7mbsr25 267 10 safely safely RB cord-024189-t7mbsr25 267 11 managed manage VBN cord-024189-t7mbsr25 267 12 with with IN cord-024189-t7mbsr25 267 13 glucocorticoids glucocorticoid NNS cord-024189-t7mbsr25 267 14 ; ; : cord-024189-t7mbsr25 267 15 doses dose NNS cord-024189-t7mbsr25 267 16 for for IN cord-024189-t7mbsr25 267 17 long long JJ cord-024189-t7mbsr25 267 18 - - HYPH cord-024189-t7mbsr25 267 19 term term NN cord-024189-t7mbsr25 267 20 treatment treatment NN cord-024189-t7mbsr25 267 21 are be VBP cord-024189-t7mbsr25 267 22 low low JJ cord-024189-t7mbsr25 267 23 and and CC cord-024189-t7mbsr25 267 24 unlikely unlikely JJ cord-024189-t7mbsr25 267 25 to to TO cord-024189-t7mbsr25 267 26 cause cause VB cord-024189-t7mbsr25 267 27 serious serious JJ cord-024189-t7mbsr25 267 28 side side NN cord-024189-t7mbsr25 267 29 effects effect NNS cord-024189-t7mbsr25 267 30 . . . cord-024189-t7mbsr25 268 1 A a DT cord-024189-t7mbsr25 268 2 critical critical JJ cord-024189-t7mbsr25 268 3 decision decision NN cord-024189-t7mbsr25 268 4 in in IN cord-024189-t7mbsr25 268 5 treating treat VBG cord-024189-t7mbsr25 268 6 PMR PMR NNP cord-024189-t7mbsr25 268 7 is be VBZ cord-024189-t7mbsr25 268 8 the the DT cord-024189-t7mbsr25 268 9 dose dose NN cord-024189-t7mbsr25 268 10 of of IN cord-024189-t7mbsr25 268 11 glucocorticoids glucocorticoid NNS cord-024189-t7mbsr25 268 12 required require VBN cord-024189-t7mbsr25 268 13 for for IN cord-024189-t7mbsr25 268 14 successful successful JJ cord-024189-t7mbsr25 268 15 suppression suppression NN cord-024189-t7mbsr25 268 16 of of IN cord-024189-t7mbsr25 268 17 symptoms symptom NNS cord-024189-t7mbsr25 268 18 and and CC cord-024189-t7mbsr25 268 19 infl infl NNP cord-024189-t7mbsr25 268 20 ammation ammation NNP cord-024189-t7mbsr25 268 21 . . . cord-024189-t7mbsr25 269 1 The the DT cord-024189-t7mbsr25 269 2 glucocorticoid glucocorticoid NN cord-024189-t7mbsr25 269 3 requirements requirement NNS cord-024189-t7mbsr25 269 4 may may MD cord-024189-t7mbsr25 269 5 differ differ VB cord-024189-t7mbsr25 269 6 quite quite RB cord-024189-t7mbsr25 269 7 markedly markedly RB cord-024189-t7mbsr25 269 8 among among IN cord-024189-t7mbsr25 269 9 patients patient NNS cord-024189-t7mbsr25 269 10 . . . cord-024189-t7mbsr25 270 1 Two two CD cord-024189-t7mbsr25 270 2 thirds third NNS cord-024189-t7mbsr25 270 3 of of IN cord-024189-t7mbsr25 270 4 patients patient NNS cord-024189-t7mbsr25 270 5 can can MD cord-024189-t7mbsr25 270 6 be be VB cord-024189-t7mbsr25 270 7 expected expect VBN cord-024189-t7mbsr25 270 8 to to TO cord-024189-t7mbsr25 270 9 respond respond VB cord-024189-t7mbsr25 270 10 with with IN cord-024189-t7mbsr25 270 11 remission remission NN cord-024189-t7mbsr25 270 12 of of IN cord-024189-t7mbsr25 270 13 pain pain NN cord-024189-t7mbsr25 270 14 and and CC cord-024189-t7mbsr25 270 15 stiffness stiffness NN cord-024189-t7mbsr25 270 16 when when WRB cord-024189-t7mbsr25 270 17 started start VBD cord-024189-t7mbsr25 270 18 on on IN cord-024189-t7mbsr25 270 19 20 20 CD cord-024189-t7mbsr25 270 20 mg mg NNP cord-024189-t7mbsr25 270 21 / / SYM cord-024189-t7mbsr25 270 22 day day NN cord-024189-t7mbsr25 270 23 or or CC cord-024189-t7mbsr25 270 24 less less JJR cord-024189-t7mbsr25 270 25 prednisone prednisone NNP cord-024189-t7mbsr25 270 26 ( ( -LRB- cord-024189-t7mbsr25 270 27 25 25 CD cord-024189-t7mbsr25 270 28 ) ) -RRB- cord-024189-t7mbsr25 270 29 . . . cord-024189-t7mbsr25 271 1 Some some DT cord-024189-t7mbsr25 271 2 patients patient NNS cord-024189-t7mbsr25 271 3 will will MD cord-024189-t7mbsr25 271 4 need need VB cord-024189-t7mbsr25 271 5 doses dose NNS cord-024189-t7mbsr25 271 6 as as RB cord-024189-t7mbsr25 271 7 high high JJ cord-024189-t7mbsr25 271 8 as as IN cord-024189-t7mbsr25 271 9 40 40 CD cord-024189-t7mbsr25 271 10 mg mg NNP cord-024189-t7mbsr25 271 11 / / SYM cord-024189-t7mbsr25 271 12 day day NN cord-024189-t7mbsr25 271 13 for for IN cord-024189-t7mbsr25 271 14 complete complete JJ cord-024189-t7mbsr25 271 15 clinical clinical JJ cord-024189-t7mbsr25 271 16 control control NN cord-024189-t7mbsr25 271 17 . . . cord-024189-t7mbsr25 272 1 Such such JJ cord-024189-t7mbsr25 272 2 patients patient NNS cord-024189-t7mbsr25 272 3 may may MD cord-024189-t7mbsr25 272 4 be be VB cord-024189-t7mbsr25 272 5 at at IN cord-024189-t7mbsr25 272 6 higher high JJR cord-024189-t7mbsr25 272 7 risk risk NN cord-024189-t7mbsr25 272 8 of of IN cord-024189-t7mbsr25 272 9 full full RB cord-024189-t7mbsr25 272 10 - - HYPH cord-024189-t7mbsr25 272 11 blown blown JJ cord-024189-t7mbsr25 272 12 GCA GCA NNP cord-024189-t7mbsr25 272 13 . . . cord-024189-t7mbsr25 273 1 Patients patient NNS cord-024189-t7mbsr25 273 2 initially initially RB cord-024189-t7mbsr25 273 3 controlled control VBN cord-024189-t7mbsr25 273 4 on on IN cord-024189-t7mbsr25 273 5 20 20 CD cord-024189-t7mbsr25 273 6 mg mg NNP cord-024189-t7mbsr25 273 7 / / SYM cord-024189-t7mbsr25 273 8 day day NN cord-024189-t7mbsr25 273 9 of of IN cord-024189-t7mbsr25 273 10 prednisone prednisone NNP cord-024189-t7mbsr25 273 11 can can MD cord-024189-t7mbsr25 273 12 usually usually RB cord-024189-t7mbsr25 273 13 taper taper VB cord-024189-t7mbsr25 273 14 the the DT cord-024189-t7mbsr25 273 15 dose dose NN cord-024189-t7mbsr25 273 16 by by IN cord-024189-t7mbsr25 273 17 2.5 2.5 CD cord-024189-t7mbsr25 273 18 mg mg NNS cord-024189-t7mbsr25 273 19 every every DT cord-024189-t7mbsr25 273 20 10 10 CD cord-024189-t7mbsr25 273 21 to to TO cord-024189-t7mbsr25 273 22 14 14 CD cord-024189-t7mbsr25 273 23 days day NNS cord-024189-t7mbsr25 273 24 . . . cord-024189-t7mbsr25 274 1 More more RBR cord-024189-t7mbsr25 274 2 protracted protracted JJ cord-024189-t7mbsr25 274 3 tapering tapering NN cord-024189-t7mbsr25 274 4 may may MD cord-024189-t7mbsr25 274 5 be be VB cord-024189-t7mbsr25 274 6 necessary necessary JJ cord-024189-t7mbsr25 274 7 once once IN cord-024189-t7mbsr25 274 8 daily daily JJ cord-024189-t7mbsr25 274 9 doses dose NNS cord-024189-t7mbsr25 274 10 of of IN cord-024189-t7mbsr25 274 11 7 7 CD cord-024189-t7mbsr25 274 12 to to TO cord-024189-t7mbsr25 274 13 8 8 CD cord-024189-t7mbsr25 274 14 mg mg NNP cord-024189-t7mbsr25 274 15 prednisone prednisone NNP cord-024189-t7mbsr25 274 16 are be VBP cord-024189-t7mbsr25 274 17 attained attain VBN cord-024189-t7mbsr25 274 18 . . . cord-024189-t7mbsr25 275 1 Dose dose NN cord-024189-t7mbsr25 275 2 adjustments adjustment NNS cord-024189-t7mbsr25 275 3 should should MD cord-024189-t7mbsr25 275 4 be be VB cord-024189-t7mbsr25 275 5 based base VBN cord-024189-t7mbsr25 275 6 mainly mainly RB cord-024189-t7mbsr25 275 7 on on IN cord-024189-t7mbsr25 275 8 clinical clinical JJ cord-024189-t7mbsr25 275 9 evaluation evaluation NN cord-024189-t7mbsr25 275 10 , , , cord-024189-t7mbsr25 275 11 not not RB cord-024189-t7mbsr25 275 12 exclusively exclusively RB cord-024189-t7mbsr25 275 13 on on IN cord-024189-t7mbsr25 275 14 laboratory laboratory NN cord-024189-t7mbsr25 275 15 abnormalities abnormality NNS cord-024189-t7mbsr25 275 16 . . . cord-024189-t7mbsr25 276 1 In in IN cord-024189-t7mbsr25 276 2 many many JJ cord-024189-t7mbsr25 276 3 patients patient NNS cord-024189-t7mbsr25 276 4 , , , cord-024189-t7mbsr25 276 5 PMR PMR NNP cord-024189-t7mbsr25 276 6 can can MD cord-024189-t7mbsr25 276 7 go go VB cord-024189-t7mbsr25 276 8 into into IN cord-024189-t7mbsr25 276 9 long long JJ cord-024189-t7mbsr25 276 10 - - HYPH cord-024189-t7mbsr25 276 11 term term NN cord-024189-t7mbsr25 276 12 remission remission NN cord-024189-t7mbsr25 276 13 , , , cord-024189-t7mbsr25 276 14 and and CC cord-024189-t7mbsr25 276 15 prednisone prednisone NN cord-024189-t7mbsr25 276 16 can can MD cord-024189-t7mbsr25 276 17 be be VB cord-024189-t7mbsr25 276 18 discontinued discontinue VBN cord-024189-t7mbsr25 276 19 . . . cord-024189-t7mbsr25 277 1 Occasionally occasionally RB cord-024189-t7mbsr25 277 2 , , , cord-024189-t7mbsr25 277 3 successful successful JJ cord-024189-t7mbsr25 277 4 suppression suppression NN cord-024189-t7mbsr25 277 5 of of IN cord-024189-t7mbsr25 277 6 recurrent recurrent JJ cord-024189-t7mbsr25 277 7 myalgias myalgia NNS cord-024189-t7mbsr25 277 8 and and CC cord-024189-t7mbsr25 277 9 stiffness stiffness NN cord-024189-t7mbsr25 277 10 may may MD cord-024189-t7mbsr25 277 11 only only RB cord-024189-t7mbsr25 277 12 be be VB cord-024189-t7mbsr25 277 13 achieved achieve VBN cord-024189-t7mbsr25 277 14 by by IN cord-024189-t7mbsr25 277 15 giving give VBG cord-024189-t7mbsr25 277 16 very very RB cord-024189-t7mbsr25 277 17 low low JJ cord-024189-t7mbsr25 277 18 doses dose NNS cord-024189-t7mbsr25 277 19 of of IN cord-024189-t7mbsr25 277 20 prednisone prednisone NN cord-024189-t7mbsr25 277 21 over over IN cord-024189-t7mbsr25 277 22 an an DT cord-024189-t7mbsr25 277 23 extended extended JJ cord-024189-t7mbsr25 277 24 period period NN cord-024189-t7mbsr25 277 25 . . . cord-024189-t7mbsr25 278 1 Patients patient NNS cord-024189-t7mbsr25 278 2 should should MD cord-024189-t7mbsr25 278 3 be be VB cord-024189-t7mbsr25 278 4 warned warn VBN cord-024189-t7mbsr25 278 5 about about IN cord-024189-t7mbsr25 278 6 the the DT cord-024189-t7mbsr25 278 7 potential potential NN cord-024189-t7mbsr25 278 8 of of IN cord-024189-t7mbsr25 278 9 PMR PMR NNP cord-024189-t7mbsr25 278 10 progressing progress VBG cord-024189-t7mbsr25 278 11 to to IN cord-024189-t7mbsr25 278 12 GCA GCA NNP cord-024189-t7mbsr25 278 13 and and CC cord-024189-t7mbsr25 278 14 should should MD cord-024189-t7mbsr25 278 15 be be VB cord-024189-t7mbsr25 278 16 monitored monitor VBN cord-024189-t7mbsr25 278 17 for for IN cord-024189-t7mbsr25 278 18 vascular vascular JJ cord-024189-t7mbsr25 278 19 complications complication NNS cord-024189-t7mbsr25 278 20 , , , cord-024189-t7mbsr25 278 21 particularly particularly RB cord-024189-t7mbsr25 278 22 when when WRB cord-024189-t7mbsr25 278 23 discontinuing discontinue VBG cord-024189-t7mbsr25 278 24 glucocorticoid glucocorticoid NN cord-024189-t7mbsr25 278 25 therapy therapy NN cord-024189-t7mbsr25 278 26 . . . cord-024189-t7mbsr25 279 1 The the DT cord-024189-t7mbsr25 279 2 prognosis prognosis NN cord-024189-t7mbsr25 279 3 of of IN cord-024189-t7mbsr25 279 4 patients patient NNS cord-024189-t7mbsr25 279 5 with with IN cord-024189-t7mbsr25 279 6 PMR PMR NNP cord-024189-t7mbsr25 279 7 is be VBZ cord-024189-t7mbsr25 279 8 good good JJ cord-024189-t7mbsr25 279 9 . . . cord-024189-t7mbsr25 280 1 In in IN cord-024189-t7mbsr25 280 2 the the DT cord-024189-t7mbsr25 280 3 majority majority NN cord-024189-t7mbsr25 280 4 of of IN cord-024189-t7mbsr25 280 5 patients patient NNS cord-024189-t7mbsr25 280 6 , , , cord-024189-t7mbsr25 280 7 the the DT cord-024189-t7mbsr25 280 8 condition condition NN cord-024189-t7mbsr25 280 9 is be VBZ cord-024189-t7mbsr25 280 10 self self NN cord-024189-t7mbsr25 280 11 - - HYPH cord-024189-t7mbsr25 280 12 limited limit VBN cord-024189-t7mbsr25 280 13 . . . cord-024189-t7mbsr25 281 1 A a DT cord-024189-t7mbsr25 281 2 proportion proportion NN cord-024189-t7mbsr25 281 3 of of IN cord-024189-t7mbsr25 281 4 patients patient NNS cord-024189-t7mbsr25 281 5 will will MD cord-024189-t7mbsr25 281 6 eventually eventually RB cord-024189-t7mbsr25 281 7 present present VB cord-024189-t7mbsr25 281 8 with with IN cord-024189-t7mbsr25 281 9 typical typical JJ cord-024189-t7mbsr25 281 10 symmetrical symmetrical JJ cord-024189-t7mbsr25 281 11 polyarthritis polyarthritis NN cord-024189-t7mbsr25 281 12 , , , cord-024189-t7mbsr25 281 13 fulfi fulfi NNP cord-024189-t7mbsr25 281 14 lling lle VBG cord-024189-t7mbsr25 281 15 the the DT cord-024189-t7mbsr25 281 16 criteria criterion NNS cord-024189-t7mbsr25 281 17 for for IN cord-024189-t7mbsr25 281 18 the the DT cord-024189-t7mbsr25 281 19 diagnosis diagnosis NN cord-024189-t7mbsr25 281 20 of of IN cord-024189-t7mbsr25 281 21 seronegative seronegative JJ cord-024189-t7mbsr25 281 22 rheumatoid rheumatoid NN cord-024189-t7mbsr25 281 23 arthritis arthritis NN cord-024189-t7mbsr25 281 24 . . . cord-024189-t7mbsr25 282 1 Such such JJ cord-024189-t7mbsr25 282 2 patients patient NNS cord-024189-t7mbsr25 282 3 may may MD cord-024189-t7mbsr25 282 4 require require VB cord-024189-t7mbsr25 282 5 disease disease NN cord-024189-t7mbsr25 282 6 - - HYPH cord-024189-t7mbsr25 282 7 modifying modify VBG cord-024189-t7mbsr25 282 8 antirheumatic antirheumatic JJ cord-024189-t7mbsr25 282 9 drug drug NN cord-024189-t7mbsr25 282 10 ( ( -LRB- cord-024189-t7mbsr25 282 11 DMARD DMARD NNP cord-024189-t7mbsr25 282 12 ) ) -RRB- cord-024189-t7mbsr25 282 13 therapy therapy NN cord-024189-t7mbsr25 282 14 . . . cord-024189-t7mbsr25 283 1 Takayasu Takayasu NNP cord-024189-t7mbsr25 283 2 's 's POS cord-024189-t7mbsr25 283 3 arteritis arteritis NN cord-024189-t7mbsr25 283 4 is be VBZ cord-024189-t7mbsr25 283 5 a a DT cord-024189-t7mbsr25 283 6 vasculitis vasculitis NN cord-024189-t7mbsr25 283 7 of of IN cord-024189-t7mbsr25 283 8 the the DT cord-024189-t7mbsr25 283 9 large large JJ cord-024189-t7mbsr25 283 10 elastic elastic JJ cord-024189-t7mbsr25 283 11 arteries artery NNS cord-024189-t7mbsr25 283 12 , , , cord-024189-t7mbsr25 283 13 specifi specifi VBN cord-024189-t7mbsr25 283 14 cally cally RB cord-024189-t7mbsr25 283 15 the the DT cord-024189-t7mbsr25 283 16 aorta aorta NN cord-024189-t7mbsr25 283 17 and and CC cord-024189-t7mbsr25 283 18 its -PRON- PRP$ cord-024189-t7mbsr25 283 19 main main JJ cord-024189-t7mbsr25 283 20 branches branch NNS cord-024189-t7mbsr25 283 21 . . . cord-024189-t7mbsr25 284 1 The the DT cord-024189-t7mbsr25 284 2 disease disease NN cord-024189-t7mbsr25 284 3 may may MD cord-024189-t7mbsr25 284 4 also also RB cord-024189-t7mbsr25 284 5 affect affect VB cord-024189-t7mbsr25 284 6 the the DT cord-024189-t7mbsr25 284 7 coronary coronary JJ cord-024189-t7mbsr25 284 8 and and CC cord-024189-t7mbsr25 284 9 pulmonary pulmonary JJ cord-024189-t7mbsr25 284 10 arteries artery NNS cord-024189-t7mbsr25 284 11 ( ( -LRB- cord-024189-t7mbsr25 284 12 28 28 CD cord-024189-t7mbsr25 284 13 ) ) -RRB- cord-024189-t7mbsr25 284 14 . . . cord-024189-t7mbsr25 285 1 Infl Infl NNP cord-024189-t7mbsr25 285 2 ammatory ammatory NNP cord-024189-t7mbsr25 285 3 injury injury NN cord-024189-t7mbsr25 285 4 to to IN cord-024189-t7mbsr25 285 5 the the DT cord-024189-t7mbsr25 285 6 vessel vessel NN cord-024189-t7mbsr25 285 7 wall wall NN cord-024189-t7mbsr25 285 8 leads lead VBZ cord-024189-t7mbsr25 285 9 to to IN cord-024189-t7mbsr25 285 10 patchy patchy JJ cord-024189-t7mbsr25 285 11 disappearance disappearance NN cord-024189-t7mbsr25 285 12 of of IN cord-024189-t7mbsr25 285 13 the the DT cord-024189-t7mbsr25 285 14 elastica elastica NN cord-024189-t7mbsr25 285 15 and and CC cord-024189-t7mbsr25 285 16 smooth smooth JJ cord-024189-t7mbsr25 285 17 muscle muscle NN cord-024189-t7mbsr25 285 18 layer layer NN cord-024189-t7mbsr25 285 19 and and CC cord-024189-t7mbsr25 285 20 subsequent subsequent JJ cord-024189-t7mbsr25 285 21 intimal intimal JJ cord-024189-t7mbsr25 285 22 hyperplasia hyperplasia NN cord-024189-t7mbsr25 285 23 , , , cord-024189-t7mbsr25 285 24 resulting result VBG cord-024189-t7mbsr25 285 25 in in IN cord-024189-t7mbsr25 285 26 vascular vascular JJ cord-024189-t7mbsr25 285 27 stenosis stenosis NN cord-024189-t7mbsr25 285 28 in in IN cord-024189-t7mbsr25 285 29 virtually virtually RB cord-024189-t7mbsr25 285 30 all all DT cord-024189-t7mbsr25 285 31 patients patient NNS cord-024189-t7mbsr25 285 32 and and CC cord-024189-t7mbsr25 285 33 dila dila NNP cord-024189-t7mbsr25 285 34 - - HYPH cord-024189-t7mbsr25 285 35 tation tation NNP cord-024189-t7mbsr25 285 36 and and CC cord-024189-t7mbsr25 285 37 aneurysm aneurysm NN cord-024189-t7mbsr25 285 38 in in IN cord-024189-t7mbsr25 285 39 about about RB cord-024189-t7mbsr25 285 40 25 25 CD cord-024189-t7mbsr25 285 41 % % NN cord-024189-t7mbsr25 285 42 . . . cord-024189-t7mbsr25 286 1 Complete complete JJ cord-024189-t7mbsr25 286 2 occlusion occlusion NN cord-024189-t7mbsr25 286 3 of of IN cord-024189-t7mbsr25 286 4 upper upper JJ cord-024189-t7mbsr25 286 5 extremity extremity NN cord-024189-t7mbsr25 286 6 arteries artery NNS cord-024189-t7mbsr25 286 7 results result NNS cord-024189-t7mbsr25 286 8 in in IN cord-024189-t7mbsr25 286 9 the the DT cord-024189-t7mbsr25 286 10 loss loss NN cord-024189-t7mbsr25 286 11 of of IN cord-024189-t7mbsr25 286 12 palpable palpable JJ cord-024189-t7mbsr25 286 13 pulses pulse NNS cord-024189-t7mbsr25 286 14 , , , cord-024189-t7mbsr25 286 15 which which WDT cord-024189-t7mbsr25 286 16 is be VBZ cord-024189-t7mbsr25 286 17 why why WRB cord-024189-t7mbsr25 286 18 TA TA NNP cord-024189-t7mbsr25 286 19 is be VBZ cord-024189-t7mbsr25 286 20 also also RB cord-024189-t7mbsr25 286 21 termed term VBN cord-024189-t7mbsr25 286 22 the the DT cord-024189-t7mbsr25 286 23 pulseless pulseless JJ cord-024189-t7mbsr25 286 24 disease disease NN cord-024189-t7mbsr25 286 25 . . . cord-024189-t7mbsr25 287 1 The the DT cord-024189-t7mbsr25 287 2 preference preference NN cord-024189-t7mbsr25 287 3 for for IN cord-024189-t7mbsr25 287 4 the the DT cord-024189-t7mbsr25 287 5 aorta aorta NN cord-024189-t7mbsr25 287 6 and and CC cord-024189-t7mbsr25 287 7 its -PRON- PRP$ cord-024189-t7mbsr25 287 8 primary primary JJ cord-024189-t7mbsr25 287 9 branches branch NNS cord-024189-t7mbsr25 287 10 is be VBZ cord-024189-t7mbsr25 287 11 signifi signifi NNP cord-024189-t7mbsr25 287 12 ed ed NNP cord-024189-t7mbsr25 287 13 in in IN cord-024189-t7mbsr25 287 14 another another DT cord-024189-t7mbsr25 287 15 alternative alternative JJ cord-024189-t7mbsr25 287 16 name name NN cord-024189-t7mbsr25 287 17 , , , cord-024189-t7mbsr25 287 18 aortic aortic JJ cord-024189-t7mbsr25 287 19 arch arch NN cord-024189-t7mbsr25 287 20 syndrome syndrome NN cord-024189-t7mbsr25 287 21 . . . cord-024189-t7mbsr25 288 1 The the DT cord-024189-t7mbsr25 288 2 ACR ACR NNP cord-024189-t7mbsr25 288 3 has have VBZ cord-024189-t7mbsr25 288 4 developed develop VBN cord-024189-t7mbsr25 288 5 a a DT cord-024189-t7mbsr25 288 6 set set NN cord-024189-t7mbsr25 288 7 of of IN cord-024189-t7mbsr25 288 8 criteria criterion NNS cord-024189-t7mbsr25 288 9 to to TO cord-024189-t7mbsr25 288 10 distinguish distinguish VB cord-024189-t7mbsr25 288 11 TA TA NNP cord-024189-t7mbsr25 288 12 from from IN cord-024189-t7mbsr25 288 13 other other JJ cord-024189-t7mbsr25 288 14 vasculitic vasculitic JJ cord-024189-t7mbsr25 288 15 syndromes syndrome NNS cord-024189-t7mbsr25 288 16 ( ( -LRB- cord-024189-t7mbsr25 288 17 see see VB cord-024189-t7mbsr25 288 18 Appendix Appendix NNP cord-024189-t7mbsr25 288 19 I i CD cord-024189-t7mbsr25 288 20 ) ) -RRB- cord-024189-t7mbsr25 288 21 . . . cord-024189-t7mbsr25 289 1 Takayasu Takayasu NNP cord-024189-t7mbsr25 289 2 's 's POS cord-024189-t7mbsr25 289 3 arteritis arteritis NN cord-024189-t7mbsr25 289 4 is be VBZ cord-024189-t7mbsr25 289 5 a a DT cord-024189-t7mbsr25 289 6 rare rare JJ cord-024189-t7mbsr25 289 7 disease disease NN cord-024189-t7mbsr25 289 8 that that WDT cord-024189-t7mbsr25 289 9 primarily primarily RB cord-024189-t7mbsr25 289 10 affects affect VBZ cord-024189-t7mbsr25 289 11 adolescent adolescent JJ cord-024189-t7mbsr25 289 12 girls girl NNS cord-024189-t7mbsr25 289 13 and and CC cord-024189-t7mbsr25 289 14 young young JJ cord-024189-t7mbsr25 289 15 women woman NNS cord-024189-t7mbsr25 289 16 . . . cord-024189-t7mbsr25 290 1 The the DT cord-024189-t7mbsr25 290 2 diagnostic diagnostic JJ cord-024189-t7mbsr25 290 3 criteria criterion NNS cord-024189-t7mbsr25 290 4 include include VBP cord-024189-t7mbsr25 290 5 an an DT cord-024189-t7mbsr25 290 6 age age NN cord-024189-t7mbsr25 290 7 of of IN cord-024189-t7mbsr25 290 8 less less JJR cord-024189-t7mbsr25 290 9 than than IN cord-024189-t7mbsr25 290 10 40 40 CD cord-024189-t7mbsr25 290 11 years year NNS cord-024189-t7mbsr25 290 12 at at IN cord-024189-t7mbsr25 290 13 disease disease NN cord-024189-t7mbsr25 290 14 onset onset NN cord-024189-t7mbsr25 290 15 ; ; : cord-024189-t7mbsr25 290 16 however however RB cord-024189-t7mbsr25 290 17 , , , cord-024189-t7mbsr25 290 18 TA TA NNP cord-024189-t7mbsr25 290 19 can can MD cord-024189-t7mbsr25 290 20 start start VB cord-024189-t7mbsr25 290 21 later later RB cord-024189-t7mbsr25 290 22 in in IN cord-024189-t7mbsr25 290 23 life life NN cord-024189-t7mbsr25 290 24 , , , cord-024189-t7mbsr25 290 25 particularly particularly RB cord-024189-t7mbsr25 290 26 in in IN cord-024189-t7mbsr25 290 27 Asians Asians NNPS cord-024189-t7mbsr25 290 28 ( ( -LRB- cord-024189-t7mbsr25 290 29 29 29 CD cord-024189-t7mbsr25 290 30 ) ) -RRB- cord-024189-t7mbsr25 290 31 . . . cord-024189-t7mbsr25 291 1 ( ( -LRB- cord-024189-t7mbsr25 291 2 In in IN cord-024189-t7mbsr25 291 3 addition addition NN cord-024189-t7mbsr25 291 4 , , , cord-024189-t7mbsr25 291 5 the the DT cord-024189-t7mbsr25 291 6 diagnosis diagnosis NN cord-024189-t7mbsr25 291 7 is be VBZ cord-024189-t7mbsr25 291 8 often often RB cord-024189-t7mbsr25 291 9 not not RB cord-024189-t7mbsr25 291 10 made make VBN cord-024189-t7mbsr25 291 11 until until IN cord-024189-t7mbsr25 291 12 the the DT cord-024189-t7mbsr25 291 13 patient patient NN cord-024189-t7mbsr25 291 14 is be VBZ cord-024189-t7mbsr25 291 15 older old JJR cord-024189-t7mbsr25 291 16 than than IN cord-024189-t7mbsr25 291 17 40 40 CD cord-024189-t7mbsr25 291 18 , , , cord-024189-t7mbsr25 291 19 but but CC cord-024189-t7mbsr25 291 20 symptoms symptom NNS cord-024189-t7mbsr25 291 21 may may MD cord-024189-t7mbsr25 291 22 have have VB cord-024189-t7mbsr25 291 23 begun begin VBN cord-024189-t7mbsr25 291 24 years year NNS cord-024189-t7mbsr25 291 25 before before IN cord-024189-t7mbsr25 291 26 the the DT cord-024189-t7mbsr25 291 27 diagnosis diagnosis NN cord-024189-t7mbsr25 291 28 . . . cord-024189-t7mbsr25 291 29 ) ) -RRB- cord-024189-t7mbsr25 292 1 Incidence incidence NN cord-024189-t7mbsr25 292 2 rates rate NNS cord-024189-t7mbsr25 292 3 are be VBP cord-024189-t7mbsr25 292 4 highest high JJS cord-024189-t7mbsr25 292 5 in in IN cord-024189-t7mbsr25 292 6 Asia Asia NNP cord-024189-t7mbsr25 292 7 ( ( -LRB- cord-024189-t7mbsr25 292 8 Japan Japan NNP cord-024189-t7mbsr25 292 9 , , , cord-024189-t7mbsr25 292 10 Korea Korea NNP cord-024189-t7mbsr25 292 11 , , , cord-024189-t7mbsr25 292 12 China China NNP cord-024189-t7mbsr25 292 13 , , , cord-024189-t7mbsr25 292 14 India India NNP cord-024189-t7mbsr25 292 15 , , , cord-024189-t7mbsr25 292 16 and and CC cord-024189-t7mbsr25 292 17 Thailand Thailand NNP cord-024189-t7mbsr25 292 18 ) ) -RRB- cord-024189-t7mbsr25 292 19 , , , cord-024189-t7mbsr25 292 20 with with IN cord-024189-t7mbsr25 292 21 estimates estimate NNS cord-024189-t7mbsr25 292 22 of of IN cord-024189-t7mbsr25 292 23 approximately approximately RB cord-024189-t7mbsr25 292 24 1 1 CD cord-024189-t7mbsr25 292 25 case case NN cord-024189-t7mbsr25 292 26 per per IN cord-024189-t7mbsr25 292 27 1 1 CD cord-024189-t7mbsr25 292 28 million million CD cord-024189-t7mbsr25 292 29 persons person NNS cord-024189-t7mbsr25 292 30 annually annually RB cord-024189-t7mbsr25 292 31 . . . cord-024189-t7mbsr25 293 1 TA TA NNP cord-024189-t7mbsr25 293 2 can can MD cord-024189-t7mbsr25 293 3 occur occur VB cord-024189-t7mbsr25 293 4 in in IN cord-024189-t7mbsr25 293 5 all all DT cord-024189-t7mbsr25 293 6 races race NNS cord-024189-t7mbsr25 293 7 and and CC cord-024189-t7mbsr25 293 8 geographic geographic JJ cord-024189-t7mbsr25 293 9 regions region NNS cord-024189-t7mbsr25 293 10 , , , cord-024189-t7mbsr25 293 11 but but CC cord-024189-t7mbsr25 293 12 South south JJ cord-024189-t7mbsr25 293 13 American american JJ cord-024189-t7mbsr25 293 14 countries country NNS cord-024189-t7mbsr25 293 15 have have VBP cord-024189-t7mbsr25 293 16 recently recently RB cord-024189-t7mbsr25 293 17 been be VBN cord-024189-t7mbsr25 293 18 recognized recognize VBN cord-024189-t7mbsr25 293 19 as as IN cord-024189-t7mbsr25 293 20 additional additional JJ cord-024189-t7mbsr25 293 21 areas area NNS cord-024189-t7mbsr25 293 22 of of IN cord-024189-t7mbsr25 293 23 relatively relatively RB cord-024189-t7mbsr25 293 24 high high JJ cord-024189-t7mbsr25 293 25 incidence incidence NN cord-024189-t7mbsr25 293 26 . . . cord-024189-t7mbsr25 294 1 An an DT cord-024189-t7mbsr25 294 2 international international JJ cord-024189-t7mbsr25 294 3 survey survey NN cord-024189-t7mbsr25 294 4 among among IN cord-024189-t7mbsr25 294 5 20 20 CD cord-024189-t7mbsr25 294 6 countries country NNS cord-024189-t7mbsr25 294 7 has have VBZ cord-024189-t7mbsr25 294 8 indicated indicate VBN cord-024189-t7mbsr25 294 9 differences difference NNS cord-024189-t7mbsr25 294 10 in in IN cord-024189-t7mbsr25 294 11 the the DT cord-024189-t7mbsr25 294 12 clinical clinical JJ cord-024189-t7mbsr25 294 13 spectrum spectrum NN cord-024189-t7mbsr25 294 14 of of IN cord-024189-t7mbsr25 294 15 TA TA NNP cord-024189-t7mbsr25 294 16 in in IN cord-024189-t7mbsr25 294 17 different different JJ cord-024189-t7mbsr25 294 18 ethnic ethnic JJ cord-024189-t7mbsr25 294 19 groups group NNS cord-024189-t7mbsr25 294 20 . . . cord-024189-t7mbsr25 295 1 Takayasu Takayasu NNP cord-024189-t7mbsr25 295 2 's 's POS cord-024189-t7mbsr25 295 3 arteritis arteritis NN cord-024189-t7mbsr25 295 4 is be VBZ cord-024189-t7mbsr25 295 5 a a DT cord-024189-t7mbsr25 295 6 granulomatous granulomatous JJ cord-024189-t7mbsr25 295 7 polyarteritis polyarteritis NN cord-024189-t7mbsr25 295 8 . . . cord-024189-t7mbsr25 296 1 The the DT cord-024189-t7mbsr25 296 2 adventitia adventitia NN cord-024189-t7mbsr25 296 3 is be VBZ cord-024189-t7mbsr25 296 4 characterized characterize VBN cord-024189-t7mbsr25 296 5 by by IN cord-024189-t7mbsr25 296 6 striking strike VBG cord-024189-t7mbsr25 296 7 thickening thickening NN cord-024189-t7mbsr25 296 8 , , , cord-024189-t7mbsr25 296 9 often often RB cord-024189-t7mbsr25 296 10 with with IN cord-024189-t7mbsr25 296 11 intense intense JJ cord-024189-t7mbsr25 296 12 perivascular perivascular NNP cord-024189-t7mbsr25 296 13 infi infi NNP cord-024189-t7mbsr25 296 14 ltrates ltrates NNP cord-024189-t7mbsr25 296 15 around around IN cord-024189-t7mbsr25 296 16 the the DT cord-024189-t7mbsr25 296 17 vasa vasa NNP cord-024189-t7mbsr25 296 18 vasorum vasorum NNP cord-024189-t7mbsr25 296 19 . . . cord-024189-t7mbsr25 297 1 Granuloma Granuloma NNP cord-024189-t7mbsr25 297 2 formation formation NN cord-024189-t7mbsr25 297 3 and and CC cord-024189-t7mbsr25 297 4 giant giant JJ cord-024189-t7mbsr25 297 5 cells cell NNS cord-024189-t7mbsr25 297 6 are be VBP cord-024189-t7mbsr25 297 7 predominantly predominantly RB cord-024189-t7mbsr25 297 8 found find VBN cord-024189-t7mbsr25 297 9 in in IN cord-024189-t7mbsr25 297 10 the the DT cord-024189-t7mbsr25 297 11 media medium NNS cord-024189-t7mbsr25 297 12 of of IN cord-024189-t7mbsr25 297 13 the the DT cord-024189-t7mbsr25 297 14 large large JJ cord-024189-t7mbsr25 297 15 elastic elastic JJ cord-024189-t7mbsr25 297 16 arteries artery NNS cord-024189-t7mbsr25 297 17 . . . cord-024189-t7mbsr25 298 1 The the DT cord-024189-t7mbsr25 298 2 medial medial JJ cord-024189-t7mbsr25 298 3 elastic elastic JJ cord-024189-t7mbsr25 298 4 smooth smooth JJ cord-024189-t7mbsr25 298 5 muscle muscle NN cord-024189-t7mbsr25 298 6 cell cell NN cord-024189-t7mbsr25 298 7 layer layer NN cord-024189-t7mbsr25 298 8 is be VBZ cord-024189-t7mbsr25 298 9 destroyed destroy VBN cord-024189-t7mbsr25 298 10 in in IN cord-024189-t7mbsr25 298 11 a a DT cord-024189-t7mbsr25 298 12 centripetal centripetal JJ cord-024189-t7mbsr25 298 13 direction direction NN cord-024189-t7mbsr25 298 14 and and CC cord-024189-t7mbsr25 298 15 replaced replace VBN cord-024189-t7mbsr25 298 16 by by IN cord-024189-t7mbsr25 298 17 fi fi NNP cord-024189-t7mbsr25 298 18 brotic brotic JJ cord-024189-t7mbsr25 298 19 tissue tissue NN cord-024189-t7mbsr25 298 20 , , , cord-024189-t7mbsr25 298 21 leading lead VBG cord-024189-t7mbsr25 298 22 ( ( -LRB- cord-024189-t7mbsr25 298 23 in in IN cord-024189-t7mbsr25 298 24 the the DT cord-024189-t7mbsr25 298 25 aorta aorta NN cord-024189-t7mbsr25 298 26 ) ) -RRB- cord-024189-t7mbsr25 298 27 to to TO cord-024189-t7mbsr25 298 28 vessel vessel VB cord-024189-t7mbsr25 298 29 wall wall NN cord-024189-t7mbsr25 298 30 dilatation dilatation NN cord-024189-t7mbsr25 298 31 and and CC cord-024189-t7mbsr25 298 32 aneurysm aneurysm NN cord-024189-t7mbsr25 298 33 formation formation NN cord-024189-t7mbsr25 298 34 . . . cord-024189-t7mbsr25 299 1 Smooth smooth JJ cord-024189-t7mbsr25 299 2 tapering tapering NN cord-024189-t7mbsr25 299 3 , , , cord-024189-t7mbsr25 299 4 narrowing narrowing NN cord-024189-t7mbsr25 299 5 , , , cord-024189-t7mbsr25 299 6 or or CC cord-024189-t7mbsr25 299 7 complete complete JJ cord-024189-t7mbsr25 299 8 occlusion occlusion NN cord-024189-t7mbsr25 299 9 of of IN cord-024189-t7mbsr25 299 10 the the DT cord-024189-t7mbsr25 299 11 vascular vascular JJ cord-024189-t7mbsr25 299 12 lumen lumen NN cord-024189-t7mbsr25 299 13 results result NNS cord-024189-t7mbsr25 299 14 from from IN cord-024189-t7mbsr25 299 15 proliferation proliferation NN cord-024189-t7mbsr25 299 16 of of IN cord-024189-t7mbsr25 299 17 the the DT cord-024189-t7mbsr25 299 18 intima intima NN cord-024189-t7mbsr25 299 19 , , , cord-024189-t7mbsr25 299 20 occasionally occasionally RB cord-024189-t7mbsr25 299 21 with with IN cord-024189-t7mbsr25 299 22 thrombosis thrombosis NN cord-024189-t7mbsr25 299 23 . . . cord-024189-t7mbsr25 300 1 The the DT cord-024189-t7mbsr25 300 2 etiology etiology NN cord-024189-t7mbsr25 300 3 of of IN cord-024189-t7mbsr25 300 4 TA TA NNP cord-024189-t7mbsr25 300 5 remains remain VBZ cord-024189-t7mbsr25 300 6 unknown unknown JJ cord-024189-t7mbsr25 300 7 . . . cord-024189-t7mbsr25 301 1 In in IN cord-024189-t7mbsr25 301 2 view view NN cord-024189-t7mbsr25 301 3 of of IN cord-024189-t7mbsr25 301 4 the the DT cord-024189-t7mbsr25 301 5 systemic systemic JJ cord-024189-t7mbsr25 301 6 features feature NNS cord-024189-t7mbsr25 301 7 of of IN cord-024189-t7mbsr25 301 8 the the DT cord-024189-t7mbsr25 301 9 syndrome syndrome NN cord-024189-t7mbsr25 301 10 , , , cord-024189-t7mbsr25 301 11 microbial microbial JJ cord-024189-t7mbsr25 301 12 infections infection NNS cord-024189-t7mbsr25 301 13 have have VBP cord-024189-t7mbsr25 301 14 been be VBN cord-024189-t7mbsr25 301 15 implicated implicate VBN cord-024189-t7mbsr25 301 16 , , , cord-024189-t7mbsr25 301 17 but but CC cord-024189-t7mbsr25 301 18 no no DT cord-024189-t7mbsr25 301 19 conclusive conclusive JJ cord-024189-t7mbsr25 301 20 evidence evidence NN cord-024189-t7mbsr25 301 21 for for IN cord-024189-t7mbsr25 301 22 infectious infectious JJ cord-024189-t7mbsr25 301 23 organisms organism NNS cord-024189-t7mbsr25 301 24 has have VBZ cord-024189-t7mbsr25 301 25 been be VBN cord-024189-t7mbsr25 301 26 provided provide VBN cord-024189-t7mbsr25 301 27 . . . cord-024189-t7mbsr25 302 1 CD8 CD8 NNP cord-024189-t7mbsr25 302 2 T T NNP cord-024189-t7mbsr25 302 3 cells cell NNS cord-024189-t7mbsr25 302 4 are be VBP cord-024189-t7mbsr25 302 5 a a DT cord-024189-t7mbsr25 302 6 major major JJ cord-024189-t7mbsr25 302 7 component component NN cord-024189-t7mbsr25 302 8 of of IN cord-024189-t7mbsr25 302 9 vascular vascular JJ cord-024189-t7mbsr25 302 10 infi infi NNP cord-024189-t7mbsr25 302 11 ltrates ltrates NNP cord-024189-t7mbsr25 302 12 , , , cord-024189-t7mbsr25 302 13 setting set VBG cord-024189-t7mbsr25 302 14 TA TA NNP cord-024189-t7mbsr25 302 15 apart apart RB cord-024189-t7mbsr25 302 16 from from IN cord-024189-t7mbsr25 302 17 GCA GCA NNP cord-024189-t7mbsr25 302 18 . . . cord-024189-t7mbsr25 303 1 Cytotoxic cytotoxic JJ cord-024189-t7mbsr25 303 2 activities activity NNS cord-024189-t7mbsr25 303 3 of of IN cord-024189-t7mbsr25 303 4 tissue tissue NN cord-024189-t7mbsr25 303 5 infi infi NNP cord-024189-t7mbsr25 303 6 ltrating ltrating NNP cord-024189-t7mbsr25 303 7 CD8 CD8 NNP cord-024189-t7mbsr25 303 8 T T NNP cord-024189-t7mbsr25 303 9 cells cell NNS cord-024189-t7mbsr25 303 10 , , , cord-024189-t7mbsr25 303 11 mediated mediate VBN cord-024189-t7mbsr25 303 12 by by IN cord-024189-t7mbsr25 303 13 the the DT cord-024189-t7mbsr25 303 14 release release NN cord-024189-t7mbsr25 303 15 of of IN cord-024189-t7mbsr25 303 16 the the DT cord-024189-t7mbsr25 303 17 poreforming poreforme VBG cord-024189-t7mbsr25 303 18 enzymes enzyme NNS cord-024189-t7mbsr25 303 19 perforin perforin NNP cord-024189-t7mbsr25 303 20 and and CC cord-024189-t7mbsr25 303 21 granzyme granzyme NNP cord-024189-t7mbsr25 303 22 B B NNP cord-024189-t7mbsr25 303 23 , , , cord-024189-t7mbsr25 303 24 have have VBP cord-024189-t7mbsr25 303 25 been be VBN cord-024189-t7mbsr25 303 26 suspected suspect VBN cord-024189-t7mbsr25 303 27 of of IN cord-024189-t7mbsr25 303 28 contributing contribute VBG cord-024189-t7mbsr25 303 29 to to IN cord-024189-t7mbsr25 303 30 smooth smooth JJ cord-024189-t7mbsr25 303 31 muscle muscle NN cord-024189-t7mbsr25 303 32 cell cell NN cord-024189-t7mbsr25 303 33 damage damage NN cord-024189-t7mbsr25 303 34 ( ( -LRB- cord-024189-t7mbsr25 303 35 30 30 CD cord-024189-t7mbsr25 303 36 ) ) -RRB- cord-024189-t7mbsr25 303 37 . . . cord-024189-t7mbsr25 304 1 Support support NN cord-024189-t7mbsr25 304 2 for for IN cord-024189-t7mbsr25 304 3 a a DT cord-024189-t7mbsr25 304 4 role role NN cord-024189-t7mbsr25 304 5 of of IN cord-024189-t7mbsr25 304 6 CD8 CD8 NNP cord-024189-t7mbsr25 304 7 T T NNP cord-024189-t7mbsr25 304 8 - - HYPH cord-024189-t7mbsr25 304 9 cell cell NN cord-024189-t7mbsr25 304 10 - - HYPH cord-024189-t7mbsr25 304 11 mediated mediate VBN cord-024189-t7mbsr25 304 12 cytolytic cytolytic JJ cord-024189-t7mbsr25 304 13 tissue tissue NN cord-024189-t7mbsr25 304 14 injury injury NN cord-024189-t7mbsr25 304 15 has have VBZ cord-024189-t7mbsr25 304 16 come come VBN cord-024189-t7mbsr25 304 17 from from IN cord-024189-t7mbsr25 304 18 the the DT cord-024189-t7mbsr25 304 19 observation observation NN cord-024189-t7mbsr25 304 20 that that WDT cord-024189-t7mbsr25 304 21 selected select VBD cord-024189-t7mbsr25 304 22 HLA HLA NNP cord-024189-t7mbsr25 304 23 class class NN cord-024189-t7mbsr25 304 24 I -PRON- PRP cord-024189-t7mbsr25 304 25 molecules molecule NNS cord-024189-t7mbsr25 304 26 , , , cord-024189-t7mbsr25 304 27 specifi specifi VBN cord-024189-t7mbsr25 304 28 cally cally RB cord-024189-t7mbsr25 304 29 HLA HLA NNP cord-024189-t7mbsr25 304 30 - - HYPH cord-024189-t7mbsr25 304 31 B52 B52 NNP cord-024189-t7mbsr25 304 32 , , , cord-024189-t7mbsr25 304 33 are be VBP cord-024189-t7mbsr25 304 34 overrepresented overrepresente VBN cord-024189-t7mbsr25 304 35 among among IN cord-024189-t7mbsr25 304 36 TA TA NNP cord-024189-t7mbsr25 304 37 patients patient NNS cord-024189-t7mbsr25 304 38 ( ( -LRB- cord-024189-t7mbsr25 304 39 31 31 CD cord-024189-t7mbsr25 304 40 ) ) -RRB- cord-024189-t7mbsr25 304 41 . . . cord-024189-t7mbsr25 305 1 CD8 CD8 NNP cord-024189-t7mbsr25 305 2 T T NNP cord-024189-t7mbsr25 305 3 cells cell NNS cord-024189-t7mbsr25 305 4 recognize recognize VBP cord-024189-t7mbsr25 305 5 antigens antigen NNS cord-024189-t7mbsr25 305 6 when when WRB cord-024189-t7mbsr25 305 7 bound bind VBN cord-024189-t7mbsr25 305 8 to to IN cord-024189-t7mbsr25 305 9 HLA HLA NNP cord-024189-t7mbsr25 305 10 class class NN cord-024189-t7mbsr25 305 11 I -PRON- PRP cord-024189-t7mbsr25 305 12 molecules molecule NNS cord-024189-t7mbsr25 305 13 . . . cord-024189-t7mbsr25 306 1 The the DT cord-024189-t7mbsr25 306 2 role role NN cord-024189-t7mbsr25 306 3 of of IN cord-024189-t7mbsr25 306 4 CD4 CD4 NNP cord-024189-t7mbsr25 306 5 T T NNP cord-024189-t7mbsr25 306 6 - - HYPH cord-024189-t7mbsr25 306 7 cell cell NN cord-024189-t7mbsr25 306 8 responses response NNS cord-024189-t7mbsr25 306 9 and and CC cord-024189-t7mbsr25 306 10 the the DT cord-024189-t7mbsr25 306 11 contribution contribution NN cord-024189-t7mbsr25 306 12 of of IN cord-024189-t7mbsr25 306 13 macrophage macrophage NN cord-024189-t7mbsr25 306 14 effector effector NN cord-024189-t7mbsr25 306 15 functions function NNS cord-024189-t7mbsr25 306 16 in in IN cord-024189-t7mbsr25 306 17 the the DT cord-024189-t7mbsr25 306 18 vascular vascular JJ cord-024189-t7mbsr25 306 19 lesions lesion NNS cord-024189-t7mbsr25 306 20 are be VBP cord-024189-t7mbsr25 306 21 not not RB cord-024189-t7mbsr25 306 22 understood understand VBN cord-024189-t7mbsr25 306 23 . . . cord-024189-t7mbsr25 307 1 The the DT cord-024189-t7mbsr25 307 2 focus focus NN cord-024189-t7mbsr25 307 3 of of IN cord-024189-t7mbsr25 307 4 lymphocytic lymphocytic NNP cord-024189-t7mbsr25 307 5 infi infi NNP cord-024189-t7mbsr25 307 6 ltrates ltrates NNP cord-024189-t7mbsr25 307 7 on on IN cord-024189-t7mbsr25 307 8 the the DT cord-024189-t7mbsr25 307 9 adventitia adventitia NN cord-024189-t7mbsr25 307 10 and and CC cord-024189-t7mbsr25 307 11 accumulation accumulation NN cord-024189-t7mbsr25 307 12 of of IN cord-024189-t7mbsr25 307 13 T t NN cord-024189-t7mbsr25 307 14 cells cell NNS cord-024189-t7mbsr25 307 15 around around IN cord-024189-t7mbsr25 307 16 vasa vasa NNP cord-024189-t7mbsr25 307 17 vasorum vasorum NNP cord-024189-t7mbsr25 307 18 makes make VBZ cord-024189-t7mbsr25 307 19 it -PRON- PRP cord-024189-t7mbsr25 307 20 less less RBR cord-024189-t7mbsr25 307 21 likely likely JJ cord-024189-t7mbsr25 307 22 that that IN cord-024189-t7mbsr25 307 23 the the DT cord-024189-t7mbsr25 307 24 macroendothelium macroendothelium NN cord-024189-t7mbsr25 307 25 has have VBZ cord-024189-t7mbsr25 307 26 major major JJ cord-024189-t7mbsr25 307 27 involvement involvement NN cord-024189-t7mbsr25 307 28 in in IN cord-024189-t7mbsr25 307 29 the the DT cord-024189-t7mbsr25 307 30 pathogenesis pathogenesis NN cord-024189-t7mbsr25 307 31 of of IN cord-024189-t7mbsr25 307 32 TA TA NNP cord-024189-t7mbsr25 307 33 . . . cord-024189-t7mbsr25 308 1 A a DT cord-024189-t7mbsr25 308 2 generalized generalized JJ cord-024189-t7mbsr25 308 3 infl infl NNP cord-024189-t7mbsr25 308 4 ammatory ammatory NNP cord-024189-t7mbsr25 308 5 syndrome syndrome NN cord-024189-t7mbsr25 308 6 with with IN cord-024189-t7mbsr25 308 7 fever fever NN cord-024189-t7mbsr25 308 8 , , , cord-024189-t7mbsr25 308 9 night night NN cord-024189-t7mbsr25 308 10 sweats sweat NNS cord-024189-t7mbsr25 308 11 , , , cord-024189-t7mbsr25 308 12 malaise malaise NN cord-024189-t7mbsr25 308 13 , , , cord-024189-t7mbsr25 308 14 anorexia anorexia NN cord-024189-t7mbsr25 308 15 , , , cord-024189-t7mbsr25 308 16 weight weight NN cord-024189-t7mbsr25 308 17 loss loss NN cord-024189-t7mbsr25 308 18 , , , cord-024189-t7mbsr25 308 19 and and CC cord-024189-t7mbsr25 308 20 diffuse diffuse VB cord-024189-t7mbsr25 308 21 myalgias myalgias NNP cord-024189-t7mbsr25 308 22 often often RB cord-024189-t7mbsr25 308 23 dominates dominate VBZ cord-024189-t7mbsr25 308 24 initial initial JJ cord-024189-t7mbsr25 308 25 manifestations manifestation NNS cord-024189-t7mbsr25 308 26 of of IN cord-024189-t7mbsr25 308 27 TA TA NNP cord-024189-t7mbsr25 308 28 . . . cord-024189-t7mbsr25 309 1 These these DT cord-024189-t7mbsr25 309 2 symptoms symptom NNS cord-024189-t7mbsr25 309 3 are be VBP cord-024189-t7mbsr25 309 4 frequently frequently RB cord-024189-t7mbsr25 309 5 misdiagnosed misdiagnose VBN cord-024189-t7mbsr25 309 6 as as IN cord-024189-t7mbsr25 309 7 infection infection NN cord-024189-t7mbsr25 309 8 . . . cord-024189-t7mbsr25 310 1 The the DT cord-024189-t7mbsr25 310 2 clinical clinical JJ cord-024189-t7mbsr25 310 3 pattern pattern NN cord-024189-t7mbsr25 310 4 of of IN cord-024189-t7mbsr25 310 5 ischemic ischemic JJ cord-024189-t7mbsr25 310 6 complications complication NNS cord-024189-t7mbsr25 310 7 that that WDT cord-024189-t7mbsr25 310 8 emergeoften emergeoften VBD cord-024189-t7mbsr25 310 9 years year NNS cord-024189-t7mbsr25 310 10 later later RB cord-024189-t7mbsr25 310 11 - - HYPH cord-024189-t7mbsr25 310 12 directly directly RB cord-024189-t7mbsr25 310 13 refl refl NN cord-024189-t7mbsr25 310 14 ect ect FW cord-024189-t7mbsr25 311 1 the the DT cord-024189-t7mbsr25 311 2 vascular vascular JJ cord-024189-t7mbsr25 311 3 territory territory NN cord-024189-t7mbsr25 311 4 targeted target VBN cord-024189-t7mbsr25 311 5 by by IN cord-024189-t7mbsr25 311 6 the the DT cord-024189-t7mbsr25 311 7 disease disease NN cord-024189-t7mbsr25 311 8 ( ( -LRB- cord-024189-t7mbsr25 311 9 Figure figure NN cord-024189-t7mbsr25 311 10 21A-4 21a-4 CD cord-024189-t7mbsr25 311 11 ) ) -RRB- cord-024189-t7mbsr25 311 12 . . . cord-024189-t7mbsr25 312 1 Involvement involvement NN cord-024189-t7mbsr25 312 2 of of IN cord-024189-t7mbsr25 312 3 the the DT cord-024189-t7mbsr25 312 4 carotid carotid JJ cord-024189-t7mbsr25 312 5 and and CC cord-024189-t7mbsr25 312 6 vertebral vertebral JJ cord-024189-t7mbsr25 312 7 arteries artery NNS cord-024189-t7mbsr25 312 8 leads lead VBZ cord-024189-t7mbsr25 312 9 to to IN cord-024189-t7mbsr25 312 10 neurologic neurologic JJ cord-024189-t7mbsr25 312 11 and and CC cord-024189-t7mbsr25 312 12 ophthalmologic ophthalmologic JJ cord-024189-t7mbsr25 312 13 symptoms symptom NNS cord-024189-t7mbsr25 312 14 , , , cord-024189-t7mbsr25 312 15 including include VBG cord-024189-t7mbsr25 312 16 dizziness dizziness NN cord-024189-t7mbsr25 312 17 , , , cord-024189-t7mbsr25 312 18 tinnitus tinnitus NN cord-024189-t7mbsr25 312 19 , , , cord-024189-t7mbsr25 312 20 headaches headache NNS cord-024189-t7mbsr25 312 21 , , , cord-024189-t7mbsr25 312 22 syncope syncope NN cord-024189-t7mbsr25 312 23 , , , cord-024189-t7mbsr25 312 24 stroke stroke NN cord-024189-t7mbsr25 312 25 , , , cord-024189-t7mbsr25 312 26 and and CC cord-024189-t7mbsr25 312 27 visual visual JJ cord-024189-t7mbsr25 312 28 disturbances disturbance NNS cord-024189-t7mbsr25 312 29 . . . cord-024189-t7mbsr25 313 1 Atrophy atrophy NN cord-024189-t7mbsr25 313 2 of of IN cord-024189-t7mbsr25 313 3 facial facial JJ cord-024189-t7mbsr25 313 4 muscles muscle NNS cord-024189-t7mbsr25 313 5 and and CC cord-024189-t7mbsr25 313 6 jaw jaw NN cord-024189-t7mbsr25 313 7 claudication claudication NN cord-024189-t7mbsr25 313 8 are be VBP cord-024189-t7mbsr25 313 9 mostly mostly RB cord-024189-t7mbsr25 313 10 late late JJ cord-024189-t7mbsr25 313 11 manifestations manifestation NNS cord-024189-t7mbsr25 313 12 . . . cord-024189-t7mbsr25 314 1 Occlu Occlu NNP cord-024189-t7mbsr25 314 2 - - HYPH cord-024189-t7mbsr25 314 3 sions sion NNS cord-024189-t7mbsr25 314 4 of of IN cord-024189-t7mbsr25 314 5 the the DT cord-024189-t7mbsr25 314 6 brachiocephalic brachiocephalic JJ cord-024189-t7mbsr25 314 7 and and CC cord-024189-t7mbsr25 314 8 subclavian subclavian JJ cord-024189-t7mbsr25 314 9 arteries artery NNS cord-024189-t7mbsr25 314 10 impair impair VBP cord-024189-t7mbsr25 314 11 blood blood NN cord-024189-t7mbsr25 314 12 fl fl NNP cord-024189-t7mbsr25 315 1 ow ow UH cord-024189-t7mbsr25 315 2 to to IN cord-024189-t7mbsr25 315 3 the the DT cord-024189-t7mbsr25 315 4 upper upper JJ cord-024189-t7mbsr25 315 5 extremities extremity NNS cord-024189-t7mbsr25 315 6 , , , cord-024189-t7mbsr25 315 7 presenting present VBG cord-024189-t7mbsr25 315 8 as as IN cord-024189-t7mbsr25 315 9 arm arm NN cord-024189-t7mbsr25 315 10 claudication claudication NN cord-024189-t7mbsr25 315 11 , , , cord-024189-t7mbsr25 315 12 pulselessness pulselessness NN cord-024189-t7mbsr25 315 13 , , , cord-024189-t7mbsr25 315 14 and and CC cord-024189-t7mbsr25 315 15 discrepant discrepant JJ cord-024189-t7mbsr25 315 16 blood blood NN cord-024189-t7mbsr25 315 17 pressures pressure NNS cord-024189-t7mbsr25 315 18 . . . cord-024189-t7mbsr25 316 1 The the DT cord-024189-t7mbsr25 316 2 detection detection NN cord-024189-t7mbsr25 316 3 of of IN cord-024189-t7mbsr25 316 4 bruits bruit NNS cord-024189-t7mbsr25 316 5 can can MD cord-024189-t7mbsr25 316 6 be be VB cord-024189-t7mbsr25 316 7 helpful helpful JJ cord-024189-t7mbsr25 316 8 in in IN cord-024189-t7mbsr25 316 9 making make VBG cord-024189-t7mbsr25 316 10 the the DT cord-024189-t7mbsr25 316 11 diagnosis diagnosis NN cord-024189-t7mbsr25 316 12 . . . cord-024189-t7mbsr25 317 1 Cardiac cardiac JJ cord-024189-t7mbsr25 317 2 disease disease NN cord-024189-t7mbsr25 317 3 , , , cord-024189-t7mbsr25 317 4 including include VBG cord-024189-t7mbsr25 317 5 ischemic ischemic JJ cord-024189-t7mbsr25 317 6 coronary coronary JJ cord-024189-t7mbsr25 317 7 disease disease NN cord-024189-t7mbsr25 317 8 , , , cord-024189-t7mbsr25 317 9 arrhythmia arrhythmia NN cord-024189-t7mbsr25 317 10 , , , cord-024189-t7mbsr25 317 11 and and CC cord-024189-t7mbsr25 317 12 congestive congestive JJ cord-024189-t7mbsr25 317 13 heart heart NN cord-024189-t7mbsr25 317 14 failure failure NN cord-024189-t7mbsr25 317 15 , , , cord-024189-t7mbsr25 317 16 can can MD cord-024189-t7mbsr25 317 17 be be VB cord-024189-t7mbsr25 317 18 related relate VBN cord-024189-t7mbsr25 317 19 to to IN cord-024189-t7mbsr25 317 20 aortitis aortitis NN cord-024189-t7mbsr25 317 21 of of IN cord-024189-t7mbsr25 317 22 the the DT cord-024189-t7mbsr25 317 23 ascending ascend VBG cord-024189-t7mbsr25 317 24 aorta aorta NN cord-024189-t7mbsr25 317 25 or or CC cord-024189-t7mbsr25 317 26 severe severe JJ cord-024189-t7mbsr25 317 27 hypertension hypertension NN cord-024189-t7mbsr25 317 28 . . . cord-024189-t7mbsr25 318 1 Aortic aortic JJ cord-024189-t7mbsr25 318 2 regurgitation regurgitation NN cord-024189-t7mbsr25 318 3 , , , cord-024189-t7mbsr25 318 4 a a DT cord-024189-t7mbsr25 318 5 serious serious JJ cord-024189-t7mbsr25 318 6 complication complication NN cord-024189-t7mbsr25 318 7 requiring require VBG cord-024189-t7mbsr25 318 8 prompt prompt JJ cord-024189-t7mbsr25 318 9 clinical clinical JJ cord-024189-t7mbsr25 318 10 attention attention NN cord-024189-t7mbsr25 318 11 , , , cord-024189-t7mbsr25 318 12 is be VBZ cord-024189-t7mbsr25 318 13 a a DT cord-024189-t7mbsr25 318 14 consequence consequence NN cord-024189-t7mbsr25 318 15 of of IN cord-024189-t7mbsr25 318 16 aortic aortic JJ cord-024189-t7mbsr25 318 17 dilatation dilatation NN cord-024189-t7mbsr25 318 18 . . . cord-024189-t7mbsr25 319 1 Coronary coronary JJ cord-024189-t7mbsr25 319 2 arteries artery NNS cord-024189-t7mbsr25 319 3 can can MD cord-024189-t7mbsr25 319 4 be be VB cord-024189-t7mbsr25 319 5 involved involve VBN cord-024189-t7mbsr25 319 6 directly directly RB cord-024189-t7mbsr25 319 7 or or CC cord-024189-t7mbsr25 319 8 indirectly indirectly RB cord-024189-t7mbsr25 319 9 , , , cord-024189-t7mbsr25 319 10 producing produce VBG cord-024189-t7mbsr25 319 11 classical classical JJ cord-024189-t7mbsr25 319 12 symptoms symptom NNS cord-024189-t7mbsr25 319 13 of of IN cord-024189-t7mbsr25 319 14 myocardial myocardial JJ cord-024189-t7mbsr25 319 15 ischemia ischemia NN cord-024189-t7mbsr25 319 16 . . . cord-024189-t7mbsr25 320 1 Progressively progressively RB cord-024189-t7mbsr25 320 2 enlarging enlarge VBG cord-024189-t7mbsr25 320 3 aneurysms aneurysm NNS cord-024189-t7mbsr25 320 4 and and CC cord-024189-t7mbsr25 320 5 possible possible JJ cord-024189-t7mbsr25 320 6 rupture rupture NN cord-024189-t7mbsr25 320 7 are be VBP cord-024189-t7mbsr25 320 8 a a DT cord-024189-t7mbsr25 320 9 major major JJ cord-024189-t7mbsr25 320 10 concern concern NN cord-024189-t7mbsr25 320 11 in in IN cord-024189-t7mbsr25 320 12 patients patient NNS cord-024189-t7mbsr25 320 13 with with IN cord-024189-t7mbsr25 320 14 TA TA NNP cord-024189-t7mbsr25 320 15 of of IN cord-024189-t7mbsr25 320 16 the the DT cord-024189-t7mbsr25 320 17 aortic aortic JJ cord-024189-t7mbsr25 320 18 arch arch NN cord-024189-t7mbsr25 320 19 and and CC cord-024189-t7mbsr25 320 20 the the DT cord-024189-t7mbsr25 320 21 descending descend VBG cord-024189-t7mbsr25 320 22 thoracic thoracic JJ cord-024189-t7mbsr25 320 23 aorta aorta NN cord-024189-t7mbsr25 320 24 . . . cord-024189-t7mbsr25 321 1 Patients patient NNS cord-024189-t7mbsr25 321 2 from from IN cord-024189-t7mbsr25 321 3 India India NNP cord-024189-t7mbsr25 321 4 , , , cord-024189-t7mbsr25 321 5 China China NNP cord-024189-t7mbsr25 321 6 , , , cord-024189-t7mbsr25 321 7 and and CC cord-024189-t7mbsr25 321 8 Korea Korea NNP cord-024189-t7mbsr25 321 9 often often RB cord-024189-t7mbsr25 321 10 have have VBP cord-024189-t7mbsr25 321 11 lesions lesion NNS cord-024189-t7mbsr25 321 12 in in IN cord-024189-t7mbsr25 321 13 the the DT cord-024189-t7mbsr25 321 14 abdominal abdominal JJ cord-024189-t7mbsr25 321 15 aorta aorta NN cord-024189-t7mbsr25 321 16 and and CC cord-024189-t7mbsr25 321 17 its -PRON- PRP$ cord-024189-t7mbsr25 321 18 branches branch NNS cord-024189-t7mbsr25 321 19 ( ( -LRB- cord-024189-t7mbsr25 321 20 particularly particularly RB cord-024189-t7mbsr25 321 21 the the DT cord-024189-t7mbsr25 321 22 renal renal JJ cord-024189-t7mbsr25 321 23 arteries artery NNS cord-024189-t7mbsr25 321 24 , , , cord-024189-t7mbsr25 321 25 causing cause VBG cord-024189-t7mbsr25 321 26 renovascular renovascular JJ cord-024189-t7mbsr25 321 27 hypertension hypertension NN cord-024189-t7mbsr25 321 28 ) ) -RRB- cord-024189-t7mbsr25 321 29 . . . cord-024189-t7mbsr25 322 1 The the DT cord-024189-t7mbsr25 322 2 proximal proximal JJ cord-024189-t7mbsr25 322 3 ends end NNS cord-024189-t7mbsr25 322 4 of of IN cord-024189-t7mbsr25 322 5 mesenteric mesenteric JJ cord-024189-t7mbsr25 322 6 arteries artery NNS cord-024189-t7mbsr25 322 7 are be VBP cord-024189-t7mbsr25 322 8 less less RBR cord-024189-t7mbsr25 322 9 frequently frequently RB cord-024189-t7mbsr25 322 10 affected affect VBN cord-024189-t7mbsr25 322 11 , , , cord-024189-t7mbsr25 322 12 but but CC cord-024189-t7mbsr25 322 13 gastrointestinal gastrointestinal JJ cord-024189-t7mbsr25 322 14 symptoms symptom NNS cord-024189-t7mbsr25 322 15 , , , cord-024189-t7mbsr25 322 16 such such JJ cord-024189-t7mbsr25 322 17 as as IN cord-024189-t7mbsr25 322 18 nausea nausea NN cord-024189-t7mbsr25 322 19 , , , cord-024189-t7mbsr25 322 20 vomiting vomit VBG cord-024189-t7mbsr25 322 21 , , , cord-024189-t7mbsr25 322 22 and and CC cord-024189-t7mbsr25 322 23 ischemic ischemic JJ cord-024189-t7mbsr25 322 24 bowel bowel NN cord-024189-t7mbsr25 322 25 disease disease NN cord-024189-t7mbsr25 322 26 can can MD cord-024189-t7mbsr25 322 27 be be VB cord-024189-t7mbsr25 322 28 seen see VBN cord-024189-t7mbsr25 322 29 in in IN cord-024189-t7mbsr25 322 30 patients patient NNS cord-024189-t7mbsr25 322 31 with with IN cord-024189-t7mbsr25 322 32 TA TA NNP cord-024189-t7mbsr25 322 33 . . . cord-024189-t7mbsr25 323 1 Patients patient NNS cord-024189-t7mbsr25 323 2 presenting present VBG cord-024189-t7mbsr25 323 3 ( ( -LRB- cord-024189-t7mbsr25 323 4 % % NN cord-024189-t7mbsr25 323 5 ) ) -RRB- cord-024189-t7mbsr25 323 6 _SP cord-024189-t7mbsr25 323 7 Clinical clinical JJ cord-024189-t7mbsr25 323 8 spectrum spectrum NN cord-024189-t7mbsr25 323 9 of of IN cord-024189-t7mbsr25 323 10 Takayasu Takayasu NNP cord-024189-t7mbsr25 323 11 's 's POS cord-024189-t7mbsr25 323 12 arteritis arteritis NN cord-024189-t7mbsr25 323 13 in in IN cord-024189-t7mbsr25 323 14 relationship relationship NN cord-024189-t7mbsr25 323 15 to to IN cord-024189-t7mbsr25 323 16 vascular vascular JJ cord-024189-t7mbsr25 323 17 bed bed NN cord-024189-t7mbsr25 323 18 involvement involvement NN cord-024189-t7mbsr25 323 19 . . . cord-024189-t7mbsr25 324 1 A a DT cord-024189-t7mbsr25 324 2 combination combination NN cord-024189-t7mbsr25 324 3 of of IN cord-024189-t7mbsr25 324 4 vaso vaso JJ cord-024189-t7mbsr25 324 5 - - HYPH cord-024189-t7mbsr25 324 6 occlusive occlusive JJ cord-024189-t7mbsr25 324 7 disease disease NN cord-024189-t7mbsr25 324 8 and and CC cord-024189-t7mbsr25 324 9 systemic systemic JJ cord-024189-t7mbsr25 324 10 infl infl NN cord-024189-t7mbsr25 324 11 ammation ammation NN cord-024189-t7mbsr25 324 12 in in IN cord-024189-t7mbsr25 324 13 a a DT cord-024189-t7mbsr25 324 14 young young JJ cord-024189-t7mbsr25 324 15 patient patient NN cord-024189-t7mbsr25 324 16 should should MD cord-024189-t7mbsr25 324 17 immediately immediately RB cord-024189-t7mbsr25 324 18 raise raise VB cord-024189-t7mbsr25 324 19 suspicion suspicion NN cord-024189-t7mbsr25 324 20 for for IN cord-024189-t7mbsr25 324 21 TA TA NNP cord-024189-t7mbsr25 324 22 . . . cord-024189-t7mbsr25 325 1 Typically typically RB cord-024189-t7mbsr25 325 2 , , , cord-024189-t7mbsr25 325 3 the the DT cord-024189-t7mbsr25 325 4 diagnosis diagnosis NN cord-024189-t7mbsr25 325 5 is be VBZ cord-024189-t7mbsr25 325 6 made make VBN cord-024189-t7mbsr25 325 7 by by IN cord-024189-t7mbsr25 325 8 characteristic characteristic JJ cord-024189-t7mbsr25 325 9 fi fi NN cord-024189-t7mbsr25 325 10 ndings nding NNS cord-024189-t7mbsr25 325 11 on on IN cord-024189-t7mbsr25 325 12 vascular vascular JJ cord-024189-t7mbsr25 325 13 imaging imaging NN cord-024189-t7mbsr25 325 14 ( ( -LRB- cord-024189-t7mbsr25 325 15 32 32 CD cord-024189-t7mbsr25 325 16 ) ) -RRB- cord-024189-t7mbsr25 325 17 . . . cord-024189-t7mbsr25 326 1 Tissue tissue NN cord-024189-t7mbsr25 326 2 is be VBZ cord-024189-t7mbsr25 326 3 rarely rarely RB cord-024189-t7mbsr25 326 4 available available JJ cord-024189-t7mbsr25 326 5 . . . cord-024189-t7mbsr25 327 1 The the DT cord-024189-t7mbsr25 327 2 fi fi NN cord-024189-t7mbsr25 327 3 ndings nding NNS cord-024189-t7mbsr25 327 4 on on IN cord-024189-t7mbsr25 327 5 conventional conventional JJ cord-024189-t7mbsr25 327 6 angiography angiography NN cord-024189-t7mbsr25 327 7 can can MD cord-024189-t7mbsr25 327 8 be be VB cord-024189-t7mbsr25 327 9 diagnostic diagnostic JJ cord-024189-t7mbsr25 327 10 for for IN cord-024189-t7mbsr25 327 11 TA TA NNP cord-024189-t7mbsr25 327 12 in in IN cord-024189-t7mbsr25 327 13 the the DT cord-024189-t7mbsr25 327 14 proper proper JJ cord-024189-t7mbsr25 327 15 clinical clinical JJ cord-024189-t7mbsr25 327 16 setting setting NN cord-024189-t7mbsr25 327 17 . . . cord-024189-t7mbsr25 328 1 Angiography angiography NN cord-024189-t7mbsr25 328 2 reveals reveal VBZ cord-024189-t7mbsr25 328 3 long long RB cord-024189-t7mbsr25 328 4 , , , cord-024189-t7mbsr25 328 5 smooth smooth JJ cord-024189-t7mbsr25 328 6 taperings tapering NNS cord-024189-t7mbsr25 328 7 of of IN cord-024189-t7mbsr25 328 8 involved involved JJ cord-024189-t7mbsr25 328 9 vessels vessel NNS cord-024189-t7mbsr25 328 10 , , , cord-024189-t7mbsr25 328 11 with with IN cord-024189-t7mbsr25 328 12 a a DT cord-024189-t7mbsr25 328 13 remarkable remarkable JJ cord-024189-t7mbsr25 328 14 web web NN cord-024189-t7mbsr25 328 15 of of IN cord-024189-t7mbsr25 328 16 collateral collateral JJ cord-024189-t7mbsr25 328 17 blood blood NN cord-024189-t7mbsr25 328 18 vessels vessel NNS cord-024189-t7mbsr25 328 19 in in IN cord-024189-t7mbsr25 328 20 advanced advanced JJ cord-024189-t7mbsr25 328 21 cases case NNS cord-024189-t7mbsr25 328 22 . . . cord-024189-t7mbsr25 329 1 As as IN cord-024189-t7mbsr25 329 2 in in IN cord-024189-t7mbsr25 329 3 GCA GCA NNP cord-024189-t7mbsr25 329 4 , , , cord-024189-t7mbsr25 329 5 conventional conventional JJ cord-024189-t7mbsr25 329 6 angiography angiography NN cord-024189-t7mbsr25 329 7 is be VBZ cord-024189-t7mbsr25 329 8 essential essential JJ cord-024189-t7mbsr25 329 9 in in IN cord-024189-t7mbsr25 329 10 many many JJ cord-024189-t7mbsr25 329 11 patients patient NNS cord-024189-t7mbsr25 329 12 with with IN cord-024189-t7mbsr25 329 13 TA TA NNP cord-024189-t7mbsr25 329 14 in in IN cord-024189-t7mbsr25 329 15 order order NN cord-024189-t7mbsr25 329 16 to to TO cord-024189-t7mbsr25 329 17 measure measure VB cord-024189-t7mbsr25 329 18 accurately accurately RB cord-024189-t7mbsr25 329 19 the the DT cord-024189-t7mbsr25 329 20 central central JJ cord-024189-t7mbsr25 329 21 aortic aortic JJ cord-024189-t7mbsr25 329 22 blood blood NN cord-024189-t7mbsr25 329 23 pressure pressure NN cord-024189-t7mbsr25 329 24 . . . cord-024189-t7mbsr25 330 1 Several several JJ cord-024189-t7mbsr25 330 2 noninvasive noninvasive JJ cord-024189-t7mbsr25 330 3 imaging imaging NN cord-024189-t7mbsr25 330 4 techniques technique NNS cord-024189-t7mbsr25 330 5 are be VBP cord-024189-t7mbsr25 330 6 informative informative JJ cord-024189-t7mbsr25 330 7 for for IN cord-024189-t7mbsr25 330 8 assessing assess VBG cord-024189-t7mbsr25 330 9 progression progression NN cord-024189-t7mbsr25 330 10 of of IN cord-024189-t7mbsr25 330 11 occlusive occlusive JJ cord-024189-t7mbsr25 330 12 disease disease NN cord-024189-t7mbsr25 330 13 , , , cord-024189-t7mbsr25 330 14 but but CC cord-024189-t7mbsr25 330 15 currently currently RB cord-024189-t7mbsr25 330 16 lack lack VBP cord-024189-t7mbsr25 330 17 standardization standardization NN cord-024189-t7mbsr25 330 18 and and CC cord-024189-t7mbsr25 330 19 are be VBP cord-024189-t7mbsr25 330 20 subject subject JJ cord-024189-t7mbsr25 330 21 to to IN cord-024189-t7mbsr25 330 22 investigator investigator NN cord-024189-t7mbsr25 330 23 bias bias NN cord-024189-t7mbsr25 330 24 and and CC cord-024189-t7mbsr25 330 25 experience experience NN cord-024189-t7mbsr25 330 26 . . . cord-024189-t7mbsr25 331 1 Far far RB cord-024189-t7mbsr25 331 2 more more RBR cord-024189-t7mbsr25 331 3 problematic problematic JJ cord-024189-t7mbsr25 331 4 than than IN cord-024189-t7mbsr25 331 5 assessing assess VBG cord-024189-t7mbsr25 331 6 the the DT cord-024189-t7mbsr25 331 7 degree degree NN cord-024189-t7mbsr25 331 8 of of IN cord-024189-t7mbsr25 331 9 stenosis stenosis NN cord-024189-t7mbsr25 331 10 within within IN cord-024189-t7mbsr25 331 11 a a DT cord-024189-t7mbsr25 331 12 given give VBN cord-024189-t7mbsr25 331 13 blood blood NN cord-024189-t7mbsr25 331 14 vessel vessel NN cord-024189-t7mbsr25 331 15 is be VBZ cord-024189-t7mbsr25 331 16 the the DT cord-024189-t7mbsr25 331 17 reliable reliable JJ cord-024189-t7mbsr25 331 18 assessment assessment NN cord-024189-t7mbsr25 331 19 of of IN cord-024189-t7mbsr25 331 20 infl infl NNP cord-024189-t7mbsr25 331 21 ammatory ammatory NNP cord-024189-t7mbsr25 331 22 activity activity NN cord-024189-t7mbsr25 331 23 by by IN cord-024189-t7mbsr25 331 24 imaging image VBG cord-024189-t7mbsr25 331 25 . . . cord-024189-t7mbsr25 332 1 MRI MRI NNP cord-024189-t7mbsr25 332 2 / / , cord-024189-t7mbsr25 332 3 A A NNP cord-024189-t7mbsr25 332 4 has have VBZ cord-024189-t7mbsr25 332 5 largely largely RB cord-024189-t7mbsr25 332 6 replaced replace VBN cord-024189-t7mbsr25 332 7 conventional conventional JJ cord-024189-t7mbsr25 332 8 angiography angiography NN cord-024189-t7mbsr25 332 9 for for IN cord-024189-t7mbsr25 332 10 serial serial JJ cord-024189-t7mbsr25 332 11 assessments assessment NNS cord-024189-t7mbsr25 332 12 of of IN cord-024189-t7mbsr25 332 13 the the DT cord-024189-t7mbsr25 332 14 distribution distribution NN cord-024189-t7mbsr25 332 15 and and CC cord-024189-t7mbsr25 332 16 degree degree NN cord-024189-t7mbsr25 332 17 of of IN cord-024189-t7mbsr25 332 18 vessel vessel NN cord-024189-t7mbsr25 332 19 involvement involvement NN cord-024189-t7mbsr25 332 20 , , , cord-024189-t7mbsr25 332 21 and and CC cord-024189-t7mbsr25 332 22 also also RB cord-024189-t7mbsr25 332 23 permits permit VBZ cord-024189-t7mbsr25 332 24 evaluations evaluation NNS cord-024189-t7mbsr25 332 25 of of IN cord-024189-t7mbsr25 332 26 the the DT cord-024189-t7mbsr25 332 27 vessel vessel NN cord-024189-t7mbsr25 332 28 wall wall NN cord-024189-t7mbsr25 332 29 as as RB cord-024189-t7mbsr25 332 30 well well RB cord-024189-t7mbsr25 332 31 as as IN cord-024189-t7mbsr25 332 32 the the DT cord-024189-t7mbsr25 332 33 lumen lumen NN cord-024189-t7mbsr25 332 34 . . . cord-024189-t7mbsr25 333 1 MRI MRI NNP cord-024189-t7mbsr25 333 2 / / , cord-024189-t7mbsr25 333 3 A A NNP cord-024189-t7mbsr25 333 4 is be VBZ cord-024189-t7mbsr25 333 5 particularly particularly RB cord-024189-t7mbsr25 333 6 important important JJ cord-024189-t7mbsr25 333 7 in in IN cord-024189-t7mbsr25 333 8 the the DT cord-024189-t7mbsr25 333 9 longitudinal longitudinal JJ cord-024189-t7mbsr25 333 10 monitoring monitoring NN cord-024189-t7mbsr25 333 11 of of IN cord-024189-t7mbsr25 333 12 TA TA NNP cord-024189-t7mbsr25 333 13 although although IN cord-024189-t7mbsr25 333 14 , , , cord-024189-t7mbsr25 333 15 as as IN cord-024189-t7mbsr25 333 16 noted note VBN cord-024189-t7mbsr25 333 17 , , , cord-024189-t7mbsr25 333 18 the the DT cord-024189-t7mbsr25 333 19 correct correct JJ cord-024189-t7mbsr25 333 20 interpretation interpretation NN cord-024189-t7mbsr25 333 21 of of IN cord-024189-t7mbsr25 333 22 all all DT cord-024189-t7mbsr25 333 23 MRI MRI NNP cord-024189-t7mbsr25 333 24 / / , cord-024189-t7mbsr25 333 25 A A NNP cord-024189-t7mbsr25 333 26 fi fi NNP cord-024189-t7mbsr25 333 27 ndings nding NNS cord-024189-t7mbsr25 333 28 is be VBZ cord-024189-t7mbsr25 333 29 not not RB cord-024189-t7mbsr25 333 30 always always RB cord-024189-t7mbsr25 333 31 clear clear JJ cord-024189-t7mbsr25 333 32 . . . cord-024189-t7mbsr25 334 1 MRI MRI NNP cord-024189-t7mbsr25 334 2 / / , cord-024189-t7mbsr25 334 3 A A NNP cord-024189-t7mbsr25 334 4 has have VBZ cord-024189-t7mbsr25 334 5 clear clear JJ cord-024189-t7mbsr25 334 6 utility utility NN cord-024189-t7mbsr25 334 7 in in IN cord-024189-t7mbsr25 334 8 monitoring monitor VBG cord-024189-t7mbsr25 334 9 the the DT cord-024189-t7mbsr25 334 10 progress progress NN cord-024189-t7mbsr25 334 11 or or CC cord-024189-t7mbsr25 334 12 stability stability NN cord-024189-t7mbsr25 334 13 of of IN cord-024189-t7mbsr25 334 14 vascular vascular JJ cord-024189-t7mbsr25 334 15 stenoses stenosis NNS cord-024189-t7mbsr25 334 16 , , , cord-024189-t7mbsr25 334 17 provided provide VBN cord-024189-t7mbsr25 334 18 that that IN cord-024189-t7mbsr25 334 19 serial serial JJ cord-024189-t7mbsr25 334 20 studies study NNS cord-024189-t7mbsr25 334 21 are be VBP cord-024189-t7mbsr25 334 22 compared compare VBN cord-024189-t7mbsr25 334 23 carefully carefully RB cord-024189-t7mbsr25 334 24 for for IN cord-024189-t7mbsr25 334 25 changes change NNS cord-024189-t7mbsr25 334 26 . . . cord-024189-t7mbsr25 335 1 Doppler Doppler NNP cord-024189-t7mbsr25 335 2 ultrasound ultrasound NN cord-024189-t7mbsr25 335 3 provides provide VBZ cord-024189-t7mbsr25 335 4 a a DT cord-024189-t7mbsr25 335 5 good good JJ cord-024189-t7mbsr25 335 6 assessment assessment NN cord-024189-t7mbsr25 335 7 of of IN cord-024189-t7mbsr25 335 8 cervical cervical JJ cord-024189-t7mbsr25 335 9 vessels vessel NNS cord-024189-t7mbsr25 335 10 . . . cord-024189-t7mbsr25 336 1 Computed compute VBN cord-024189-t7mbsr25 336 2 tomography tomography NN cord-024189-t7mbsr25 336 3 angiography angiography NN cord-024189-t7mbsr25 336 4 can can MD cord-024189-t7mbsr25 336 5 be be VB cord-024189-t7mbsr25 336 6 used use VBN cord-024189-t7mbsr25 336 7 to to TO cord-024189-t7mbsr25 336 8 survey survey VB cord-024189-t7mbsr25 336 9 the the DT cord-024189-t7mbsr25 336 10 aorta aorta NN cord-024189-t7mbsr25 336 11 and and CC cord-024189-t7mbsr25 336 12 proximal proximal JJ cord-024189-t7mbsr25 336 13 vessels vessel NNS cord-024189-t7mbsr25 336 14 , , , cord-024189-t7mbsr25 336 15 but but CC cord-024189-t7mbsr25 336 16 rigorous rigorous JJ cord-024189-t7mbsr25 336 17 serial serial JJ cord-024189-t7mbsr25 336 18 studies study NNS cord-024189-t7mbsr25 336 19 of of IN cord-024189-t7mbsr25 336 20 its -PRON- PRP$ cord-024189-t7mbsr25 336 21 use use NN cord-024189-t7mbsr25 336 22 in in IN cord-024189-t7mbsr25 336 23 TA TA NNP cord-024189-t7mbsr25 336 24 remain remain VBP cord-024189-t7mbsr25 336 25 to to TO cord-024189-t7mbsr25 336 26 be be VB cord-024189-t7mbsr25 336 27 performed perform VBN cord-024189-t7mbsr25 336 28 . . . cord-024189-t7mbsr25 337 1 The the DT cord-024189-t7mbsr25 337 2 role role NN cord-024189-t7mbsr25 337 3 of of IN cord-024189-t7mbsr25 337 4 PET pet JJ cord-024189-t7mbsr25 337 5 scanning scanning NN cord-024189-t7mbsr25 337 6 in in IN cord-024189-t7mbsr25 337 7 gauging gauge VBG cord-024189-t7mbsr25 337 8 the the DT cord-024189-t7mbsr25 337 9 degree degree NN cord-024189-t7mbsr25 337 10 of of IN cord-024189-t7mbsr25 337 11 ongoing ongoing JJ cord-024189-t7mbsr25 337 12 infl infl NN cord-024189-t7mbsr25 337 13 ammation ammation NN cord-024189-t7mbsr25 337 14 ( ( -LRB- cord-024189-t7mbsr25 337 15 as as IN cord-024189-t7mbsr25 337 16 opposed oppose VBN cord-024189-t7mbsr25 337 17 to to IN cord-024189-t7mbsr25 337 18 uptake uptake NN cord-024189-t7mbsr25 337 19 that that WDT cord-024189-t7mbsr25 337 20 might may MD cord-024189-t7mbsr25 337 21 be be VB cord-024189-t7mbsr25 337 22 related relate VBN cord-024189-t7mbsr25 337 23 to to IN cord-024189-t7mbsr25 337 24 a a DT cord-024189-t7mbsr25 337 25 process process NN cord-024189-t7mbsr25 337 26 of of IN cord-024189-t7mbsr25 337 27 healing healing NN cord-024189-t7mbsr25 337 28 or or CC cord-024189-t7mbsr25 337 29 fi fi NN cord-024189-t7mbsr25 337 30 brosis brosis NN cord-024189-t7mbsr25 337 31 ) ) -RRB- cord-024189-t7mbsr25 337 32 has have VBZ cord-024189-t7mbsr25 337 33 not not RB cord-024189-t7mbsr25 337 34 been be VBN cord-024189-t7mbsr25 337 35 established establish VBN cord-024189-t7mbsr25 337 36 . . . cord-024189-t7mbsr25 338 1 Although although IN cord-024189-t7mbsr25 338 2 some some DT cord-024189-t7mbsr25 338 3 patients patient NNS cord-024189-t7mbsr25 338 4 with with IN cord-024189-t7mbsr25 338 5 TA TA NNP cord-024189-t7mbsr25 338 6 have have VBP cord-024189-t7mbsr25 338 7 disease disease NN cord-024189-t7mbsr25 338 8 that that WDT cord-024189-t7mbsr25 338 9 appears appear VBZ cord-024189-t7mbsr25 338 10 to to TO cord-024189-t7mbsr25 338 11 " " `` cord-024189-t7mbsr25 338 12 burn burn VB cord-024189-t7mbsr25 338 13 out out RP cord-024189-t7mbsr25 338 14 , , , cord-024189-t7mbsr25 338 15 " " '' cord-024189-t7mbsr25 338 16 becoming become VBG cord-024189-t7mbsr25 338 17 quiescent quiescent JJ cord-024189-t7mbsr25 338 18 after after IN cord-024189-t7mbsr25 338 19 years year NNS cord-024189-t7mbsr25 338 20 of of IN cord-024189-t7mbsr25 338 21 active active JJ cord-024189-t7mbsr25 338 22 disease disease NN cord-024189-t7mbsr25 338 23 , , , cord-024189-t7mbsr25 338 24 most most JJS cord-024189-t7mbsr25 338 25 patients patient NNS cord-024189-t7mbsr25 338 26 have have VBP cord-024189-t7mbsr25 338 27 progressive progressive JJ cord-024189-t7mbsr25 338 28 or or CC cord-024189-t7mbsr25 338 29 relapsing relapse VBG cord-024189-t7mbsr25 338 30 / / SYM cord-024189-t7mbsr25 338 31 remitting remit VBG cord-024189-t7mbsr25 338 32 disease disease NN cord-024189-t7mbsr25 338 33 and and CC cord-024189-t7mbsr25 338 34 require require VB cord-024189-t7mbsr25 338 35 long long JJ cord-024189-t7mbsr25 338 36 - - HYPH cord-024189-t7mbsr25 338 37 term term NN cord-024189-t7mbsr25 338 38 immunosuppressive immunosuppressive JJ cord-024189-t7mbsr25 338 39 treatment treatment NN cord-024189-t7mbsr25 338 40 ( ( -LRB- cord-024189-t7mbsr25 338 41 33 33 CD cord-024189-t7mbsr25 338 42 ) ) -RRB- cord-024189-t7mbsr25 338 43 . . . cord-024189-t7mbsr25 339 1 Glucocorticoids Glucocorticoids NNP cord-024189-t7mbsr25 339 2 are be VBP cord-024189-t7mbsr25 339 3 the the DT cord-024189-t7mbsr25 339 4 therapy therapy NN cord-024189-t7mbsr25 339 5 of of IN cord-024189-t7mbsr25 339 6 choice choice NN cord-024189-t7mbsr25 339 7 for for IN cord-024189-t7mbsr25 339 8 management management NN cord-024189-t7mbsr25 339 9 of of IN cord-024189-t7mbsr25 339 10 TA TA NNP cord-024189-t7mbsr25 339 11 . . . cord-024189-t7mbsr25 340 1 Recommendations recommendation NNS cord-024189-t7mbsr25 340 2 of of IN cord-024189-t7mbsr25 340 3 initial initial JJ cord-024189-t7mbsr25 340 4 doses dose NNS cord-024189-t7mbsr25 340 5 have have VBP cord-024189-t7mbsr25 340 6 varied vary VBN cord-024189-t7mbsr25 340 7 , , , cord-024189-t7mbsr25 340 8 but but CC cord-024189-t7mbsr25 340 9 40 40 CD cord-024189-t7mbsr25 340 10 to to TO cord-024189-t7mbsr25 340 11 60 60 CD cord-024189-t7mbsr25 340 12 mg mg NN cord-024189-t7mbsr25 340 13 of of IN cord-024189-t7mbsr25 340 14 prednisone prednisone NNP cord-024189-t7mbsr25 340 15 may may MD cord-024189-t7mbsr25 340 16 be be VB cord-024189-t7mbsr25 340 17 necessary necessary JJ cord-024189-t7mbsr25 340 18 to to TO cord-024189-t7mbsr25 340 19 control control VB cord-024189-t7mbsr25 340 20 vascular vascular JJ cord-024189-t7mbsr25 340 21 as as RB cord-024189-t7mbsr25 340 22 well well RB cord-024189-t7mbsr25 340 23 as as IN cord-024189-t7mbsr25 340 24 systemic systemic JJ cord-024189-t7mbsr25 340 25 infl infl NN cord-024189-t7mbsr25 340 26 ammation ammation NN cord-024189-t7mbsr25 340 27 . . . cord-024189-t7mbsr25 341 1 Monitoring monitoring NN cord-024189-t7mbsr25 341 2 of of IN cord-024189-t7mbsr25 341 3 acute acute JJ cord-024189-t7mbsr25 341 4 phase phase NN cord-024189-t7mbsr25 341 5 reactants reactant NNS cord-024189-t7mbsr25 341 6 ( ( -LRB- cord-024189-t7mbsr25 341 7 ESR ESR NNP cord-024189-t7mbsr25 341 8 , , , cord-024189-t7mbsr25 341 9 CRP CRP NNP cord-024189-t7mbsr25 341 10 ) ) -RRB- cord-024189-t7mbsr25 341 11 is be VBZ cord-024189-t7mbsr25 341 12 only only RB cord-024189-t7mbsr25 341 13 helpful helpful JJ cord-024189-t7mbsr25 341 14 in in IN cord-024189-t7mbsr25 341 15 a a DT cord-024189-t7mbsr25 341 16 subset subset NN cord-024189-t7mbsr25 341 17 of of IN cord-024189-t7mbsr25 341 18 patients patient NNS cord-024189-t7mbsr25 341 19 . . . cord-024189-t7mbsr25 342 1 In in IN cord-024189-t7mbsr25 342 2 a a DT cord-024189-t7mbsr25 342 3 National National NNP cord-024189-t7mbsr25 342 4 Institutes Institutes NNPS cord-024189-t7mbsr25 342 5 of of IN cord-024189-t7mbsr25 342 6 Health Health NNP cord-024189-t7mbsr25 342 7 ( ( -LRB- cord-024189-t7mbsr25 342 8 NIH NIH NNP cord-024189-t7mbsr25 342 9 ) ) -RRB- cord-024189-t7mbsr25 342 10 cohort cohort NN cord-024189-t7mbsr25 342 11 , , , cord-024189-t7mbsr25 342 12 50 50 CD cord-024189-t7mbsr25 342 13 % % NN cord-024189-t7mbsr25 342 14 of of IN cord-024189-t7mbsr25 342 15 patients patient NNS cord-024189-t7mbsr25 342 16 had have VBD cord-024189-t7mbsr25 342 17 active active JJ cord-024189-t7mbsr25 342 18 progressing progress VBG cord-024189-t7mbsr25 342 19 disease disease NN cord-024189-t7mbsr25 342 20 despite despite IN cord-024189-t7mbsr25 342 21 nonelevated nonelevate VBN cord-024189-t7mbsr25 342 22 acute acute JJ cord-024189-t7mbsr25 342 23 phase phase NN cord-024189-t7mbsr25 342 24 reactants reactant NNS cord-024189-t7mbsr25 342 25 ( ( -LRB- cord-024189-t7mbsr25 342 26 34 34 CD cord-024189-t7mbsr25 342 27 ) ) -RRB- cord-024189-t7mbsr25 342 28 . . . cord-024189-t7mbsr25 343 1 Prednisone Prednisone NNP cord-024189-t7mbsr25 343 2 doses dose NNS cord-024189-t7mbsr25 343 3 are be VBP cord-024189-t7mbsr25 343 4 tapered taper VBN cord-024189-t7mbsr25 343 5 as as IN cord-024189-t7mbsr25 343 6 clinically clinically RB cord-024189-t7mbsr25 343 7 indicated indicate VBN cord-024189-t7mbsr25 343 8 and and CC cord-024189-t7mbsr25 343 9 tolerated tolerate VBN cord-024189-t7mbsr25 343 10 , , , cord-024189-t7mbsr25 343 11 usually usually RB cord-024189-t7mbsr25 343 12 by by IN cord-024189-t7mbsr25 343 13 5 5 CD cord-024189-t7mbsr25 343 14 mg mg NNP cord-024189-t7mbsr25 343 15 / / SYM cord-024189-t7mbsr25 343 16 day day NN cord-024189-t7mbsr25 343 17 every every DT cord-024189-t7mbsr25 343 18 2 2 CD cord-024189-t7mbsr25 343 19 weeks week NNS cord-024189-t7mbsr25 343 20 until until IN cord-024189-t7mbsr25 343 21 a a DT cord-024189-t7mbsr25 343 22 maintenance maintenance NN cord-024189-t7mbsr25 343 23 dose dose NN cord-024189-t7mbsr25 343 24 of of IN cord-024189-t7mbsr25 343 25 10 10 CD cord-024189-t7mbsr25 343 26 mg mg NNP cord-024189-t7mbsr25 343 27 / / SYM cord-024189-t7mbsr25 343 28 day day NN cord-024189-t7mbsr25 343 29 is be VBZ cord-024189-t7mbsr25 343 30 reached reach VBN cord-024189-t7mbsr25 343 31 . . . cord-024189-t7mbsr25 344 1 Further further JJ cord-024189-t7mbsr25 344 2 dose dose NN cord-024189-t7mbsr25 344 3 reductions reduction NNS cord-024189-t7mbsr25 344 4 must must MD cord-024189-t7mbsr25 344 5 be be VB cord-024189-t7mbsr25 344 6 tailored tailor VBN cord-024189-t7mbsr25 344 7 to to IN cord-024189-t7mbsr25 344 8 the the DT cord-024189-t7mbsr25 344 9 individual individual JJ cord-024189-t7mbsr25 344 10 patient patient NN cord-024189-t7mbsr25 344 11 . . . cord-024189-t7mbsr25 345 1 Low low JJ cord-024189-t7mbsr25 345 2 - - HYPH cord-024189-t7mbsr25 345 3 dose dose NN cord-024189-t7mbsr25 345 4 aspirin aspirin NN cord-024189-t7mbsr25 345 5 or or CC cord-024189-t7mbsr25 345 6 other other JJ cord-024189-t7mbsr25 345 7 antiplatelet antiplatelet NN cord-024189-t7mbsr25 345 8 agents agent NNS cord-024189-t7mbsr25 345 9 should should MD cord-024189-t7mbsr25 345 10 complement complement VB cord-024189-t7mbsr25 345 11 glucocorticoid glucocorticoid NN cord-024189-t7mbsr25 345 12 therapy therapy NN cord-024189-t7mbsr25 345 13 . . . cord-024189-t7mbsr25 346 1 Methotrexate Methotrexate NNP cord-024189-t7mbsr25 346 2 , , , cord-024189-t7mbsr25 346 3 given give VBN cord-024189-t7mbsr25 346 4 in in IN cord-024189-t7mbsr25 346 5 weekly weekly JJ cord-024189-t7mbsr25 346 6 doses dose NNS cord-024189-t7mbsr25 346 7 of of IN cord-024189-t7mbsr25 346 8 up up IN cord-024189-t7mbsr25 346 9 to to TO cord-024189-t7mbsr25 346 10 25 25 CD cord-024189-t7mbsr25 346 11 mg mg NNS cord-024189-t7mbsr25 346 12 , , , cord-024189-t7mbsr25 346 13 has have VBZ cord-024189-t7mbsr25 346 14 shown show VBN cord-024189-t7mbsr25 346 15 promise promise NN cord-024189-t7mbsr25 346 16 in in IN cord-024189-t7mbsr25 346 17 improving improve VBG cord-024189-t7mbsr25 346 18 remission remission NN cord-024189-t7mbsr25 346 19 rates rate NNS cord-024189-t7mbsr25 346 20 and and CC cord-024189-t7mbsr25 346 21 sparing spare VBG cord-024189-t7mbsr25 346 22 glucocorticoids glucocorticoid NNS cord-024189-t7mbsr25 346 23 ( ( -LRB- cord-024189-t7mbsr25 346 24 35 35 CD cord-024189-t7mbsr25 346 25 ) ) -RRB- cord-024189-t7mbsr25 346 26 , , , cord-024189-t7mbsr25 346 27 but but CC cord-024189-t7mbsr25 346 28 has have VBZ cord-024189-t7mbsr25 346 29 never never RB cord-024189-t7mbsr25 346 30 been be VBN cord-024189-t7mbsr25 346 31 tested test VBN cord-024189-t7mbsr25 346 32 in in IN cord-024189-t7mbsr25 346 33 a a DT cord-024189-t7mbsr25 346 34 randomized randomized JJ cord-024189-t7mbsr25 346 35 trial trial NN cord-024189-t7mbsr25 346 36 ( ( -LRB- cord-024189-t7mbsr25 346 37 the the DT cord-024189-t7mbsr25 346 38 same same JJ cord-024189-t7mbsr25 346 39 is be VBZ cord-024189-t7mbsr25 346 40 true true JJ cord-024189-t7mbsr25 346 41 for for IN cord-024189-t7mbsr25 346 42 all all DT cord-024189-t7mbsr25 346 43 other other JJ cord-024189-t7mbsr25 346 44 potential potential JJ cord-024189-t7mbsr25 346 45 steroid steroid NN cord-024189-t7mbsr25 346 46 - - HYPH cord-024189-t7mbsr25 346 47 sparing spare VBG cord-024189-t7mbsr25 346 48 agents agent NNS cord-024189-t7mbsr25 346 49 ) ) -RRB- cord-024189-t7mbsr25 346 50 . . . cord-024189-t7mbsr25 347 1 Azathioprine Azathioprine NNP cord-024189-t7mbsr25 347 2 , , , cord-024189-t7mbsr25 347 3 mycophenolate mycophenolate NNP cord-024189-t7mbsr25 347 4 mofetil mofetil NNP cord-024189-t7mbsr25 347 5 , , , cord-024189-t7mbsr25 347 6 cyclosporine cyclosporine NN cord-024189-t7mbsr25 347 7 , , , cord-024189-t7mbsr25 347 8 and and CC cord-024189-t7mbsr25 347 9 TNFalpha TNFalpha NNS cord-024189-t7mbsr25 347 10 blockers blocker NNS cord-024189-t7mbsr25 347 11 have have VBP cord-024189-t7mbsr25 347 12 been be VBN cord-024189-t7mbsr25 347 13 used use VBN cord-024189-t7mbsr25 347 14 with with IN cord-024189-t7mbsr25 347 15 reported report VBN cord-024189-t7mbsr25 347 16 success success NN cord-024189-t7mbsr25 347 17 in in IN cord-024189-t7mbsr25 347 18 individual individual JJ cord-024189-t7mbsr25 347 19 patients patient NNS cord-024189-t7mbsr25 347 20 , , , cord-024189-t7mbsr25 347 21 but but CC cord-024189-t7mbsr25 347 22 controlled control VBN cord-024189-t7mbsr25 347 23 studies study NNS cord-024189-t7mbsr25 347 24 are be VBP cord-024189-t7mbsr25 347 25 required require VBN cord-024189-t7mbsr25 347 26 . . . cord-024189-t7mbsr25 348 1 Contrary contrary JJ cord-024189-t7mbsr25 348 2 to to IN cord-024189-t7mbsr25 348 3 other other JJ cord-024189-t7mbsr25 348 4 vasculitides vasculitide NNS cord-024189-t7mbsr25 348 5 , , , cord-024189-t7mbsr25 348 6 cyclophosphamide cyclophosphamide RB cord-024189-t7mbsr25 348 7 does do VBZ cord-024189-t7mbsr25 348 8 not not RB cord-024189-t7mbsr25 348 9 play play VB cord-024189-t7mbsr25 348 10 a a DT cord-024189-t7mbsr25 348 11 major major JJ cord-024189-t7mbsr25 348 12 role role NN cord-024189-t7mbsr25 348 13 in in IN cord-024189-t7mbsr25 348 14 this this DT cord-024189-t7mbsr25 348 15 disease disease NN cord-024189-t7mbsr25 348 16 because because IN cord-024189-t7mbsr25 348 17 of of IN cord-024189-t7mbsr25 348 18 its -PRON- PRP$ cord-024189-t7mbsr25 348 19 toxicity toxicity NN cord-024189-t7mbsr25 348 20 and and CC cord-024189-t7mbsr25 348 21 uncertain uncertain JJ cord-024189-t7mbsr25 348 22 effi effi NNP cord-024189-t7mbsr25 348 23 cacy cacy NNP cord-024189-t7mbsr25 348 24 . . . cord-024189-t7mbsr25 349 1 Stenotic stenotic JJ cord-024189-t7mbsr25 349 2 lesions lesion NNS cord-024189-t7mbsr25 349 3 are be VBP cord-024189-t7mbsr25 349 4 irreversible irreversible JJ cord-024189-t7mbsr25 349 5 . . . cord-024189-t7mbsr25 350 1 Surgical surgical JJ cord-024189-t7mbsr25 350 2 management management NN cord-024189-t7mbsr25 350 3 and and CC cord-024189-t7mbsr25 350 4 angioplasty angioplasty NN cord-024189-t7mbsr25 350 5 or or CC cord-024189-t7mbsr25 350 6 stent stent NN cord-024189-t7mbsr25 350 7 placement placement NN cord-024189-t7mbsr25 350 8 have have VBP cord-024189-t7mbsr25 350 9 a a DT cord-024189-t7mbsr25 350 10 role role NN cord-024189-t7mbsr25 350 11 in in IN cord-024189-t7mbsr25 350 12 selected select VBN cord-024189-t7mbsr25 350 13 patients patient NNS cord-024189-t7mbsr25 350 14 , , , cord-024189-t7mbsr25 350 15 but but CC cord-024189-t7mbsr25 350 16 for for IN cord-024189-t7mbsr25 350 17 most most JJS cord-024189-t7mbsr25 350 18 patients patient NNS cord-024189-t7mbsr25 350 19 revascularization revascularization NN cord-024189-t7mbsr25 350 20 attempts attempt NNS cord-024189-t7mbsr25 350 21 of of IN cord-024189-t7mbsr25 350 22 vessels vessel NNS cord-024189-t7mbsr25 350 23 to to IN cord-024189-t7mbsr25 350 24 the the DT cord-024189-t7mbsr25 350 25 extremities extremity NNS cord-024189-t7mbsr25 350 26 are be VBP cord-024189-t7mbsr25 350 27 not not RB cord-024189-t7mbsr25 350 28 necessary necessary JJ cord-024189-t7mbsr25 350 29 because because IN cord-024189-t7mbsr25 350 30 of of IN cord-024189-t7mbsr25 350 31 the the DT cord-024189-t7mbsr25 350 32 exuberant exuberant JJ cord-024189-t7mbsr25 350 33 collateralization collateralization NN cord-024189-t7mbsr25 350 34 that that WDT cord-024189-t7mbsr25 350 35 develops develop VBZ cord-024189-t7mbsr25 350 36 in in IN cord-024189-t7mbsr25 350 37 TA TA NNP cord-024189-t7mbsr25 350 38 . . . cord-024189-t7mbsr25 351 1 When when WRB cord-024189-t7mbsr25 351 2 revascularization revascularization NN cord-024189-t7mbsr25 351 3 is be VBZ cord-024189-t7mbsr25 351 4 necessary necessary JJ cord-024189-t7mbsr25 351 5 , , , cord-024189-t7mbsr25 351 6 bypass bypass NN cord-024189-t7mbsr25 351 7 grafts graft NNS cord-024189-t7mbsr25 351 8 are be VBP cord-024189-t7mbsr25 351 9 generally generally RB cord-024189-t7mbsr25 351 10 successful successful JJ cord-024189-t7mbsr25 351 11 , , , cord-024189-t7mbsr25 351 12 while while IN cord-024189-t7mbsr25 351 13 stenting stenting NN cord-024189-t7mbsr25 351 14 appears appear VBZ cord-024189-t7mbsr25 351 15 to to TO cord-024189-t7mbsr25 351 16 have have VB cord-024189-t7mbsr25 351 17 a a DT cord-024189-t7mbsr25 351 18 high high JJ cord-024189-t7mbsr25 351 19 rate rate NN cord-024189-t7mbsr25 351 20 of of IN cord-024189-t7mbsr25 351 21 reocclusion reocclusion NN cord-024189-t7mbsr25 351 22 ( ( -LRB- cord-024189-t7mbsr25 351 23 33 33 CD cord-024189-t7mbsr25 351 24 ) ) -RRB- cord-024189-t7mbsr25 351 25 . . . cord-024189-t7mbsr25 352 1 Angioplasty angioplasty NN cord-024189-t7mbsr25 352 2 is be VBZ cord-024189-t7mbsr25 352 3 reserved reserve VBN cord-024189-t7mbsr25 352 4 for for IN cord-024189-t7mbsr25 352 5 short short JJ cord-024189-t7mbsr25 352 6 stenotic stenotic JJ cord-024189-t7mbsr25 352 7 segments segment NNS cord-024189-t7mbsr25 352 8 . . . cord-024189-t7mbsr25 353 1 Treatment treatment NN cord-024189-t7mbsr25 353 2 of of IN cord-024189-t7mbsr25 353 3 hypertension hypertension NN cord-024189-t7mbsr25 353 4 secondary secondary JJ cord-024189-t7mbsr25 353 5 to to IN cord-024189-t7mbsr25 353 6 renal renal JJ cord-024189-t7mbsr25 353 7 artery artery NN cord-024189-t7mbsr25 353 8 stenosis stenosis NN cord-024189-t7mbsr25 353 9 may may MD cord-024189-t7mbsr25 353 10 or or CC cord-024189-t7mbsr25 353 11 may may MD cord-024189-t7mbsr25 353 12 not not RB cord-024189-t7mbsr25 353 13 benefi benefi VB cord-024189-t7mbsr25 353 14 t t NN cord-024189-t7mbsr25 353 15 from from IN cord-024189-t7mbsr25 353 16 revascularization revascularization NN cord-024189-t7mbsr25 353 17 , , , cord-024189-t7mbsr25 353 18 depending depend VBG cord-024189-t7mbsr25 353 19 on on IN cord-024189-t7mbsr25 353 20 the the DT cord-024189-t7mbsr25 353 21 location location NN cord-024189-t7mbsr25 353 22 of of IN cord-024189-t7mbsr25 353 23 the the DT cord-024189-t7mbsr25 353 24 lesion lesion NN cord-024189-t7mbsr25 353 25 leading lead VBG cord-024189-t7mbsr25 353 26 to to IN cord-024189-t7mbsr25 353 27 renovascular renovascular JJ cord-024189-t7mbsr25 353 28 hypertension hypertension NN cord-024189-t7mbsr25 353 29 . . . cord-024189-t7mbsr25 354 1 Decisions decision NNS cord-024189-t7mbsr25 354 2 about about IN cord-024189-t7mbsr25 354 3 whether whether IN cord-024189-t7mbsr25 354 4 or or CC cord-024189-t7mbsr25 354 5 not not RB cord-024189-t7mbsr25 354 6 to to TO cord-024189-t7mbsr25 354 7 attempt attempt VB cord-024189-t7mbsr25 354 8 revascularization revascularization NN cord-024189-t7mbsr25 354 9 should should MD cord-024189-t7mbsr25 354 10 be be VB cord-024189-t7mbsr25 354 11 undertaken undertake VBN cord-024189-t7mbsr25 354 12 in in IN cord-024189-t7mbsr25 354 13 consultation consultation NN cord-024189-t7mbsr25 354 14 with with IN cord-024189-t7mbsr25 354 15 experts expert NNS cord-024189-t7mbsr25 354 16 accustomed accustom VBN cord-024189-t7mbsr25 354 17 to to IN cord-024189-t7mbsr25 354 18 the the DT cord-024189-t7mbsr25 354 19 management management NN cord-024189-t7mbsr25 354 20 of of IN cord-024189-t7mbsr25 354 21 complex complex JJ cord-024189-t7mbsr25 354 22 hypertension hypertension NN cord-024189-t7mbsr25 354 23 cases case NNS cord-024189-t7mbsr25 354 24 . . . cord-024189-t7mbsr25 355 1 For for IN cord-024189-t7mbsr25 355 2 much much JJ cord-024189-t7mbsr25 355 3 of of IN cord-024189-t7mbsr25 355 4 the the DT cord-024189-t7mbsr25 355 5 past past JJ cord-024189-t7mbsr25 355 6 several several JJ cord-024189-t7mbsr25 355 7 decades decade NNS cord-024189-t7mbsr25 355 8 , , , cord-024189-t7mbsr25 355 9 TA TA NNP cord-024189-t7mbsr25 355 10 has have VBZ cord-024189-t7mbsr25 355 11 been be VBN cord-024189-t7mbsr25 355 12 viewed view VBN cord-024189-t7mbsr25 355 13 as as IN cord-024189-t7mbsr25 355 14 an an DT cord-024189-t7mbsr25 355 15 inevitably inevitably RB cord-024189-t7mbsr25 355 16 devastating devastating JJ cord-024189-t7mbsr25 355 17 disease disease NN cord-024189-t7mbsr25 355 18 . . . cord-024189-t7mbsr25 356 1 The the DT cord-024189-t7mbsr25 356 2 diagnosis diagnosis NN cord-024189-t7mbsr25 356 3 was be VBD cord-024189-t7mbsr25 356 4 seldom seldom RB cord-024189-t7mbsr25 356 5 made make VBN cord-024189-t7mbsr25 356 6 before before IN cord-024189-t7mbsr25 356 7 damage damage NN cord-024189-t7mbsr25 356 8 from from IN cord-024189-t7mbsr25 356 9 prolonged prolong VBN cord-024189-t7mbsr25 356 10 vascular vascular JJ cord-024189-t7mbsr25 356 11 infl infl NN cord-024189-t7mbsr25 356 12 ammation ammation NN cord-024189-t7mbsr25 356 13 was be VBD cord-024189-t7mbsr25 356 14 already already RB cord-024189-t7mbsr25 356 15 extensive extensive JJ cord-024189-t7mbsr25 356 16 . . . cord-024189-t7mbsr25 357 1 More more RBR cord-024189-t7mbsr25 357 2 recently recently RB cord-024189-t7mbsr25 357 3 , , , cord-024189-t7mbsr25 357 4 the the DT cord-024189-t7mbsr25 357 5 potential potential NN cord-024189-t7mbsr25 357 6 for for IN cord-024189-t7mbsr25 357 7 earlier early JJR cord-024189-t7mbsr25 357 8 diagnosis diagnosis NN cord-024189-t7mbsr25 357 9 , , , cord-024189-t7mbsr25 357 10 effective effective JJ cord-024189-t7mbsr25 357 11 immunosuppressive immunosuppressive JJ cord-024189-t7mbsr25 357 12 therapy therapy NN cord-024189-t7mbsr25 357 13 , , , cord-024189-t7mbsr25 357 14 and and CC cord-024189-t7mbsr25 357 15 astute astute JJ cord-024189-t7mbsr25 357 16 surgical surgical JJ cord-024189-t7mbsr25 357 17 management management NN cord-024189-t7mbsr25 357 18 have have VBP cord-024189-t7mbsr25 357 19 led lead VBN cord-024189-t7mbsr25 357 20 to to IN cord-024189-t7mbsr25 357 21 an an DT cord-024189-t7mbsr25 357 22 improved improved JJ cord-024189-t7mbsr25 357 23 prognosis prognosis NN cord-024189-t7mbsr25 357 24 for for IN cord-024189-t7mbsr25 357 25 many many JJ cord-024189-t7mbsr25 357 26 patients patient NNS cord-024189-t7mbsr25 357 27 . . . cord-024189-t7mbsr25 358 1 Long long JJ cord-024189-t7mbsr25 358 2 - - HYPH cord-024189-t7mbsr25 358 3 term term NN cord-024189-t7mbsr25 358 4 follow follow VB cord-024189-t7mbsr25 358 5 up up IN cord-024189-t7mbsr25 358 6 of of IN cord-024189-t7mbsr25 358 7 almost almost RB cord-024189-t7mbsr25 358 8 1000 1000 CD cord-024189-t7mbsr25 358 9 Japanese japanese JJ cord-024189-t7mbsr25 358 10 patients patient NNS cord-024189-t7mbsr25 358 11 found find VBD cord-024189-t7mbsr25 358 12 stable stable JJ cord-024189-t7mbsr25 358 13 clinical clinical JJ cord-024189-t7mbsr25 358 14 conditions condition NNS cord-024189-t7mbsr25 358 15 in in IN cord-024189-t7mbsr25 358 16 two two CD cord-024189-t7mbsr25 358 17 thirds third NNS cord-024189-t7mbsr25 358 18 of of IN cord-024189-t7mbsr25 358 19 the the DT cord-024189-t7mbsr25 358 20 patients patient NNS cord-024189-t7mbsr25 358 21 and and CC cord-024189-t7mbsr25 358 22 serious serious JJ cord-024189-t7mbsr25 358 23 complications complication NNS cord-024189-t7mbsr25 358 24 occurring occur VBG cord-024189-t7mbsr25 358 25 in in IN cord-024189-t7mbsr25 358 26 only only RB cord-024189-t7mbsr25 358 27 25 25 CD cord-024189-t7mbsr25 358 28 % % NN cord-024189-t7mbsr25 358 29 of of IN cord-024189-t7mbsr25 358 30 affected affect VBN cord-024189-t7mbsr25 358 31 individuals individual NNS cord-024189-t7mbsr25 358 32 . . . cord-024189-t7mbsr25 359 1 Cardiac cardiac JJ cord-024189-t7mbsr25 359 2 complications complication NNS cord-024189-t7mbsr25 359 3 , , , cord-024189-t7mbsr25 359 4 including include VBG cord-024189-t7mbsr25 359 5 congestive congestive JJ cord-024189-t7mbsr25 359 6 heart heart NN cord-024189-t7mbsr25 359 7 failure failure NN cord-024189-t7mbsr25 359 8 and and CC cord-024189-t7mbsr25 359 9 ischemic ischemic JJ cord-024189-t7mbsr25 359 10 heart heart NN cord-024189-t7mbsr25 359 11 disease disease NN cord-024189-t7mbsr25 359 12 , , , cord-024189-t7mbsr25 359 13 have have VBP cord-024189-t7mbsr25 359 14 become become VBN cord-024189-t7mbsr25 359 15 the the DT cord-024189-t7mbsr25 359 16 most most RBS cord-024189-t7mbsr25 359 17 common common JJ cord-024189-t7mbsr25 359 18 cause cause NN cord-024189-t7mbsr25 359 19 of of IN cord-024189-t7mbsr25 359 20 death death NN cord-024189-t7mbsr25 359 21 in in IN cord-024189-t7mbsr25 359 22 Japanese japanese JJ cord-024189-t7mbsr25 359 23 patients patient NNS cord-024189-t7mbsr25 359 24 with with IN cord-024189-t7mbsr25 359 25 TA TA NNP cord-024189-t7mbsr25 359 26 . . . cord-024189-t7mbsr25 360 1 Acceleration acceleration NN cord-024189-t7mbsr25 360 2 of of IN cord-024189-t7mbsr25 360 3 atherosclerotic atherosclerotic JJ cord-024189-t7mbsr25 360 4 disease disease NN cord-024189-t7mbsr25 360 5 emerges emerge VBZ cord-024189-t7mbsr25 360 6 as as IN cord-024189-t7mbsr25 360 7 a a DT cord-024189-t7mbsr25 360 8 critical critical JJ cord-024189-t7mbsr25 360 9 factor factor NN cord-024189-t7mbsr25 360 10 in in IN cord-024189-t7mbsr25 360 11 long long JJ cord-024189-t7mbsr25 360 12 - - HYPH cord-024189-t7mbsr25 360 13 term term NN cord-024189-t7mbsr25 360 14 outcome outcome NN cord-024189-t7mbsr25 360 15 . . . cord-024189-t7mbsr25 361 1 Polyarteritis Polyarteritis NNP cord-024189-t7mbsr25 361 2 nodosa nodosa RB cord-024189-t7mbsr25 361 3 ( ( -LRB- cord-024189-t7mbsr25 361 4 PAN PAN NNP cord-024189-t7mbsr25 361 5 ) ) -RRB- cord-024189-t7mbsr25 361 6 primarily primarily RB cord-024189-t7mbsr25 361 7 affects affect VBZ cord-024189-t7mbsr25 361 8 mediumsized mediumsized JJ cord-024189-t7mbsr25 361 9 arteries artery NNS cord-024189-t7mbsr25 361 10 that that WDT cord-024189-t7mbsr25 361 11 supply supply VBP cord-024189-t7mbsr25 361 12 the the DT cord-024189-t7mbsr25 361 13 skin skin NN cord-024189-t7mbsr25 361 14 , , , cord-024189-t7mbsr25 361 15 gut gut NN cord-024189-t7mbsr25 361 16 , , , cord-024189-t7mbsr25 361 17 nerve nerve NN cord-024189-t7mbsr25 361 18 , , , cord-024189-t7mbsr25 361 19 and and CC cord-024189-t7mbsr25 361 20 kidney kidney NN cord-024189-t7mbsr25 361 21 , , , cord-024189-t7mbsr25 361 22 but but CC cord-024189-t7mbsr25 361 23 may may MD cord-024189-t7mbsr25 361 24 involve involve VB cord-024189-t7mbsr25 361 25 multiple multiple JJ cord-024189-t7mbsr25 361 26 organs organ NNS cord-024189-t7mbsr25 361 27 . . . cord-024189-t7mbsr25 362 1 Microaneurysms microaneurysm NNS cord-024189-t7mbsr25 362 2 of of IN cord-024189-t7mbsr25 362 3 arteries artery NNS cord-024189-t7mbsr25 362 4 to to IN cord-024189-t7mbsr25 362 5 or or CC cord-024189-t7mbsr25 362 6 within within IN cord-024189-t7mbsr25 362 7 the the DT cord-024189-t7mbsr25 362 8 kidneys kidney NNS cord-024189-t7mbsr25 362 9 , , , cord-024189-t7mbsr25 362 10 liver liver NN cord-024189-t7mbsr25 362 11 , , , cord-024189-t7mbsr25 362 12 or or CC cord-024189-t7mbsr25 362 13 gastrointestinal gastrointestinal JJ cord-024189-t7mbsr25 362 14 tract tract NN cord-024189-t7mbsr25 362 15 are be VBP cord-024189-t7mbsr25 362 16 highly highly RB cord-024189-t7mbsr25 362 17 characteristic characteristic JJ cord-024189-t7mbsr25 362 18 of of IN cord-024189-t7mbsr25 362 19 PAN PAN NNP cord-024189-t7mbsr25 362 20 . . . cord-024189-t7mbsr25 363 1 Polyarteritis Polyarteritis NNP cord-024189-t7mbsr25 363 2 nodosa nodosa RB cord-024189-t7mbsr25 363 3 is be VBZ cord-024189-t7mbsr25 363 4 not not RB cord-024189-t7mbsr25 363 5 associated associate VBN cord-024189-t7mbsr25 363 6 with with IN cord-024189-t7mbsr25 363 7 antineutrophil antineutrophil JJ cord-024189-t7mbsr25 363 8 cytoplasmic cytoplasmic JJ cord-024189-t7mbsr25 363 9 antibodies antibody NNS cord-024189-t7mbsr25 363 10 ( ( -LRB- cord-024189-t7mbsr25 363 11 ANCA ANCA NNP cord-024189-t7mbsr25 363 12 ) ) -RRB- cord-024189-t7mbsr25 363 13 directed direct VBD cord-024189-t7mbsr25 363 14 against against IN cord-024189-t7mbsr25 363 15 either either DT cord-024189-t7mbsr25 363 16 proteinase-3 proteinase-3 NNP cord-024189-t7mbsr25 363 17 or or CC cord-024189-t7mbsr25 363 18 myeloperoxidase myeloperoxidase NN cord-024189-t7mbsr25 363 19 . . . cord-024189-t7mbsr25 364 1 Mononeuritis Mononeuritis NNP cord-024189-t7mbsr25 364 2 multiplex multiplex NN cord-024189-t7mbsr25 364 3 , , , cord-024189-t7mbsr25 364 4 an an DT cord-024189-t7mbsr25 364 5 asymmetric asymmetric JJ cord-024189-t7mbsr25 364 6 sensory sensory NN cord-024189-t7mbsr25 364 7 and and CC cord-024189-t7mbsr25 364 8 motor motor NN cord-024189-t7mbsr25 364 9 neuropathy neuropathy NN cord-024189-t7mbsr25 364 10 due due IN cord-024189-t7mbsr25 364 11 to to IN cord-024189-t7mbsr25 364 12 ischemia ischemia NN cord-024189-t7mbsr25 364 13 and and CC cord-024189-t7mbsr25 364 14 infarction infarction NN cord-024189-t7mbsr25 364 15 of of IN cord-024189-t7mbsr25 364 16 peripheral peripheral JJ cord-024189-t7mbsr25 364 17 nerves nerve NNS cord-024189-t7mbsr25 364 18 , , , cord-024189-t7mbsr25 364 19 occurs occur VBZ cord-024189-t7mbsr25 364 20 frequently frequently RB cord-024189-t7mbsr25 364 21 in in IN cord-024189-t7mbsr25 364 22 PAN PAN NNP cord-024189-t7mbsr25 364 23 . . . cord-024189-t7mbsr25 365 1 In in IN cord-024189-t7mbsr25 365 2 mononeuritis mononeuritis NN cord-024189-t7mbsr25 365 3 multiplex multiplex NN cord-024189-t7mbsr25 365 4 , , , cord-024189-t7mbsr25 365 5 nerve nerve NN cord-024189-t7mbsr25 365 6 conduction conduction NN cord-024189-t7mbsr25 365 7 studies study NNS cord-024189-t7mbsr25 365 8 of of IN cord-024189-t7mbsr25 365 9 peripheral peripheral JJ cord-024189-t7mbsr25 365 10 nerves nerve NNS cord-024189-t7mbsr25 365 11 reveal reveal VBP cord-024189-t7mbsr25 365 12 a a DT cord-024189-t7mbsr25 365 13 distal distal JJ cord-024189-t7mbsr25 365 14 , , , cord-024189-t7mbsr25 365 15 asymmetric asymmetric JJ cord-024189-t7mbsr25 365 16 , , , cord-024189-t7mbsr25 365 17 axonal axonal JJ cord-024189-t7mbsr25 365 18 neuropathy neuropathy NN cord-024189-t7mbsr25 365 19 involving involve VBG cord-024189-t7mbsr25 365 20 both both CC cord-024189-t7mbsr25 365 21 motor motor NN cord-024189-t7mbsr25 365 22 and and CC cord-024189-t7mbsr25 365 23 sensory sensory JJ cord-024189-t7mbsr25 365 24 nerves nerve NNS cord-024189-t7mbsr25 365 25 . . . cord-024189-t7mbsr25 366 1 Polyarteritis Polyarteritis NNP cord-024189-t7mbsr25 366 2 nodosa nodosa RB cord-024189-t7mbsr25 366 3 is be VBZ cord-024189-t7mbsr25 366 4 characterized characterize VBN cord-024189-t7mbsr25 366 5 pathologically pathologically RB cord-024189-t7mbsr25 366 6 by by IN cord-024189-t7mbsr25 366 7 patchy patchy JJ cord-024189-t7mbsr25 366 8 , , , cord-024189-t7mbsr25 366 9 transmural transmural JJ cord-024189-t7mbsr25 366 10 infl infl NNP cord-024189-t7mbsr25 366 11 ammation ammation NNP cord-024189-t7mbsr25 366 12 in in IN cord-024189-t7mbsr25 366 13 medium medium NN cord-024189-t7mbsr25 366 14 - - HYPH cord-024189-t7mbsr25 366 15 and and CC cord-024189-t7mbsr25 366 16 small small JJ cord-024189-t7mbsr25 366 17 - - HYPH cord-024189-t7mbsr25 366 18 sized sized JJ cord-024189-t7mbsr25 366 19 muscular muscular JJ cord-024189-t7mbsr25 366 20 arteries artery NNS cord-024189-t7mbsr25 366 21 , , , cord-024189-t7mbsr25 366 22 sparing spare VBG cord-024189-t7mbsr25 366 23 large large JJ cord-024189-t7mbsr25 366 24 arteries artery NNS cord-024189-t7mbsr25 366 25 , , , cord-024189-t7mbsr25 366 26 capillaries capillary NNS cord-024189-t7mbsr25 366 27 , , , cord-024189-t7mbsr25 366 28 and and CC cord-024189-t7mbsr25 366 29 the the DT cord-024189-t7mbsr25 366 30 venous venous JJ cord-024189-t7mbsr25 366 31 system system NN cord-024189-t7mbsr25 366 32 . . . cord-024189-t7mbsr25 367 1 The the DT cord-024189-t7mbsr25 367 2 infl infl NN cord-024189-t7mbsr25 367 3 ammation ammation NN cord-024189-t7mbsr25 367 4 leads lead VBZ cord-024189-t7mbsr25 367 5 to to IN cord-024189-t7mbsr25 367 6 fi fi VB cord-024189-t7mbsr25 367 7 brinoid brinoid JJ cord-024189-t7mbsr25 367 8 necrosis necrosis NN cord-024189-t7mbsr25 367 9 , , , cord-024189-t7mbsr25 367 10 but but CC cord-024189-t7mbsr25 367 11 is be VBZ cord-024189-t7mbsr25 367 12 not not RB cord-024189-t7mbsr25 367 13 associated associate VBN cord-024189-t7mbsr25 367 14 with with IN cord-024189-t7mbsr25 367 15 granulomatous granulomatous JJ cord-024189-t7mbsr25 367 16 features feature NNS cord-024189-t7mbsr25 367 17 . . . cord-024189-t7mbsr25 368 1 High high JJ cord-024189-t7mbsr25 368 2 - - HYPH cord-024189-t7mbsr25 368 3 dose dose NN cord-024189-t7mbsr25 368 4 glucocorticoids glucocorticoid NNS cord-024189-t7mbsr25 368 5 are be VBP cord-024189-t7mbsr25 368 6 the the DT cord-024189-t7mbsr25 368 7 mainstay mainstay NN cord-024189-t7mbsr25 368 8 of of IN cord-024189-t7mbsr25 368 9 therapy therapy NN cord-024189-t7mbsr25 368 10 in in IN cord-024189-t7mbsr25 368 11 PAN PAN NNP cord-024189-t7mbsr25 368 12 . . . cord-024189-t7mbsr25 369 1 In in IN cord-024189-t7mbsr25 369 2 cases case NNS cord-024189-t7mbsr25 369 3 that that WDT cord-024189-t7mbsr25 369 4 are be VBP cord-024189-t7mbsr25 369 5 rapidly rapidly RB cord-024189-t7mbsr25 369 6 progressive progressive JJ cord-024189-t7mbsr25 369 7 or or CC cord-024189-t7mbsr25 369 8 life life NN cord-024189-t7mbsr25 369 9 - - HYPH cord-024189-t7mbsr25 369 10 or or CC cord-024189-t7mbsr25 369 11 organ organ NN cord-024189-t7mbsr25 369 12 - - HYPH cord-024189-t7mbsr25 369 13 threatening threaten VBG cord-024189-t7mbsr25 369 14 , , , cord-024189-t7mbsr25 369 15 however however RB cord-024189-t7mbsr25 369 16 , , , cord-024189-t7mbsr25 369 17 cyclophosphamide cyclophosphamide RB cord-024189-t7mbsr25 369 18 is be VBZ cord-024189-t7mbsr25 369 19 added add VBN cord-024189-t7mbsr25 369 20 to to IN cord-024189-t7mbsr25 369 21 glucocorticoid glucocorticoid NN cord-024189-t7mbsr25 369 22 treatment treatment NN cord-024189-t7mbsr25 369 23 . . . cord-024189-t7mbsr25 370 1 Most Most JJS cord-024189-t7mbsr25 370 2 cases case NNS cord-024189-t7mbsr25 370 3 of of IN cord-024189-t7mbsr25 370 4 idiopathic idiopathic JJ cord-024189-t7mbsr25 370 5 PAN PAN NNP cord-024189-t7mbsr25 370 6 do do VBP cord-024189-t7mbsr25 370 7 not not RB cord-024189-t7mbsr25 370 8 recur recur VB cord-024189-t7mbsr25 370 9 once once RB cord-024189-t7mbsr25 370 10 a a DT cord-024189-t7mbsr25 370 11 sound sound JJ cord-024189-t7mbsr25 370 12 remission remission NN cord-024189-t7mbsr25 370 13 has have VBZ cord-024189-t7mbsr25 370 14 been be VBN cord-024189-t7mbsr25 370 15 achieved achieve VBN cord-024189-t7mbsr25 370 16 with with IN cord-024189-t7mbsr25 370 17 6 6 CD cord-024189-t7mbsr25 370 18 to to TO cord-024189-t7mbsr25 370 19 12 12 CD cord-024189-t7mbsr25 370 20 months month NNS cord-024189-t7mbsr25 370 21 of of IN cord-024189-t7mbsr25 370 22 therapy therapy NN cord-024189-t7mbsr25 370 23 . . . cord-024189-t7mbsr25 371 1 A a DT cord-024189-t7mbsr25 371 2 minority minority NN cord-024189-t7mbsr25 371 3 of of IN cord-024189-t7mbsr25 371 4 PAN PAN NNP cord-024189-t7mbsr25 371 5 cases case NNS cord-024189-t7mbsr25 371 6 ( ( -LRB- cord-024189-t7mbsr25 371 7 now now RB cord-024189-t7mbsr25 371 8 > > XX cord-024189-t7mbsr25 371 9 10 10 CD cord-024189-t7mbsr25 371 10 % % NN cord-024189-t7mbsr25 371 11 ) ) -RRB- cord-024189-t7mbsr25 371 12 are be VBP cord-024189-t7mbsr25 371 13 associated associate VBN cord-024189-t7mbsr25 371 14 with with IN cord-024189-t7mbsr25 371 15 acute acute JJ cord-024189-t7mbsr25 371 16 hepatitis hepatitis NN cord-024189-t7mbsr25 371 17 B B NNP cord-024189-t7mbsr25 371 18 infection infection NN cord-024189-t7mbsr25 371 19 . . . cord-024189-t7mbsr25 372 1 Cases case NNS cord-024189-t7mbsr25 372 2 associated associate VBN cord-024189-t7mbsr25 372 3 with with IN cord-024189-t7mbsr25 372 4 hepatitis hepatitis NN cord-024189-t7mbsr25 372 5 B B NNP cord-024189-t7mbsr25 372 6 are be VBP cord-024189-t7mbsr25 372 7 treated treat VBN cord-024189-t7mbsr25 372 8 with with IN cord-024189-t7mbsr25 372 9 regimens regimen NNS cord-024189-t7mbsr25 372 10 emphasizing emphasize VBG cord-024189-t7mbsr25 372 11 antiviral antiviral JJ cord-024189-t7mbsr25 372 12 therapy therapy NN cord-024189-t7mbsr25 372 13 and and CC cord-024189-t7mbsr25 372 14 only only JJ cord-024189-t7mbsr25 372 15 short short JJ cord-024189-t7mbsr25 372 16 courses course NNS cord-024189-t7mbsr25 372 17 of of IN cord-024189-t7mbsr25 372 18 immunosuppression immunosuppression NN cord-024189-t7mbsr25 372 19 and and CC cord-024189-t7mbsr25 372 20 plasmapheresis plasmapheresis NN cord-024189-t7mbsr25 372 21 . . . cord-024189-t7mbsr25 373 1 Polyarteritis Polyarteritis NNP cord-024189-t7mbsr25 373 2 nodosa nodosa RB cord-024189-t7mbsr25 373 3 ( ( -LRB- cord-024189-t7mbsr25 373 4 PAN PAN NNP cord-024189-t7mbsr25 373 5 ) ) -RRB- cord-024189-t7mbsr25 373 6 is be VBZ cord-024189-t7mbsr25 373 7 a a DT cord-024189-t7mbsr25 373 8 vasculitis vasculitis NN cord-024189-t7mbsr25 373 9 affecting affect VBG cord-024189-t7mbsr25 373 10 predominantly predominantly RB cord-024189-t7mbsr25 373 11 medium medium JJ cord-024189-t7mbsr25 373 12 - - HYPH cord-024189-t7mbsr25 373 13 sized sized JJ cord-024189-t7mbsr25 373 14 arteries artery NNS cord-024189-t7mbsr25 373 15 . . . cord-024189-t7mbsr25 374 1 Clinically clinically RB cord-024189-t7mbsr25 374 2 , , , cord-024189-t7mbsr25 374 3 PAN PAN NNP cord-024189-t7mbsr25 374 4 often often RB cord-024189-t7mbsr25 374 5 presents present VBZ cord-024189-t7mbsr25 374 6 insidiously insidiously RB cord-024189-t7mbsr25 374 7 with with IN cord-024189-t7mbsr25 374 8 nonspecifi nonspecifi NNP cord-024189-t7mbsr25 374 9 c c NN cord-024189-t7mbsr25 374 10 , , , cord-024189-t7mbsr25 374 11 constitutional constitutional JJ cord-024189-t7mbsr25 374 12 symptoms symptom NNS cord-024189-t7mbsr25 374 13 . . . cord-024189-t7mbsr25 375 1 The the DT cord-024189-t7mbsr25 375 2 disease disease NN cord-024189-t7mbsr25 375 3 has have VBZ cord-024189-t7mbsr25 375 4 a a DT cord-024189-t7mbsr25 375 5 predilection predilection NN cord-024189-t7mbsr25 375 6 for for IN cord-024189-t7mbsr25 375 7 mediumsized mediumsized JJ cord-024189-t7mbsr25 375 8 arteries artery NNS cord-024189-t7mbsr25 375 9 supplying supply VBG cord-024189-t7mbsr25 375 10 skin skin NN cord-024189-t7mbsr25 375 11 , , , cord-024189-t7mbsr25 375 12 gut gut NN cord-024189-t7mbsr25 375 13 , , , cord-024189-t7mbsr25 375 14 nerve nerve NN cord-024189-t7mbsr25 375 15 , , , cord-024189-t7mbsr25 375 16 and and CC cord-024189-t7mbsr25 375 17 kidney kidney NN cord-024189-t7mbsr25 375 18 , , , cord-024189-t7mbsr25 375 19 but but CC cord-024189-t7mbsr25 375 20 may may MD cord-024189-t7mbsr25 375 21 involve involve VB cord-024189-t7mbsr25 375 22 multiple multiple JJ cord-024189-t7mbsr25 375 23 organs organ NNS cord-024189-t7mbsr25 375 24 . . . cord-024189-t7mbsr25 376 1 The the DT cord-024189-t7mbsr25 376 2 majority majority NN cord-024189-t7mbsr25 376 3 of of IN cord-024189-t7mbsr25 376 4 PAN PAN NNP cord-024189-t7mbsr25 376 5 cases case NNS cord-024189-t7mbsr25 376 6 have have VBP cord-024189-t7mbsr25 376 7 no no DT cord-024189-t7mbsr25 376 8 known know VBN cord-024189-t7mbsr25 376 9 cause cause NN cord-024189-t7mbsr25 376 10 , , , cord-024189-t7mbsr25 376 11 but but CC cord-024189-t7mbsr25 376 12 cases case NNS cord-024189-t7mbsr25 376 13 secondary secondary JJ cord-024189-t7mbsr25 376 14 to to IN cord-024189-t7mbsr25 376 15 hepatitis hepatitis NNP cord-024189-t7mbsr25 376 16 B B NNP cord-024189-t7mbsr25 376 17 virus virus NN cord-024189-t7mbsr25 376 18 infection infection NN cord-024189-t7mbsr25 376 19 have have VBP cord-024189-t7mbsr25 376 20 been be VBN cord-024189-t7mbsr25 376 21 reported report VBN cord-024189-t7mbsr25 376 22 . . . cord-024189-t7mbsr25 377 1 Described describe VBN cord-024189-t7mbsr25 377 2 by by IN cord-024189-t7mbsr25 377 3 Kussmaul Kussmaul NNP cord-024189-t7mbsr25 377 4 and and CC cord-024189-t7mbsr25 377 5 Maier Maier NNP cord-024189-t7mbsr25 377 6 in in IN cord-024189-t7mbsr25 377 7 1866 1866 CD cord-024189-t7mbsr25 377 8 ( ( -LRB- cord-024189-t7mbsr25 377 9 1,2 1,2 CD cord-024189-t7mbsr25 377 10 ) ) -RRB- cord-024189-t7mbsr25 377 11 , , , cord-024189-t7mbsr25 377 12 PAN PAN NNP cord-024189-t7mbsr25 377 13 is be VBZ cord-024189-t7mbsr25 377 14 often often RB cord-024189-t7mbsr25 377 15 regarded regard VBN cord-024189-t7mbsr25 377 16 as as IN cord-024189-t7mbsr25 377 17 the the DT cord-024189-t7mbsr25 377 18 fi fi NNP cord-024189-t7mbsr25 377 19 rst rst NNP cord-024189-t7mbsr25 377 20 reported report VBN cord-024189-t7mbsr25 377 21 form form NN cord-024189-t7mbsr25 377 22 of of IN cord-024189-t7mbsr25 377 23 systemic systemic JJ cord-024189-t7mbsr25 377 24 vasculitis vasculitis NN cord-024189-t7mbsr25 377 25 . . . cord-024189-t7mbsr25 378 1 In in IN cord-024189-t7mbsr25 378 2 fact fact NN cord-024189-t7mbsr25 378 3 , , , cord-024189-t7mbsr25 378 4 earlier early JJR cord-024189-t7mbsr25 378 5 descriptions description NNS cord-024189-t7mbsr25 378 6 of of IN cord-024189-t7mbsr25 378 7 Behcet Behcet NNP cord-024189-t7mbsr25 378 8 's 's POS cord-024189-t7mbsr25 378 9 disease disease NN cord-024189-t7mbsr25 378 10 , , , cord-024189-t7mbsr25 378 11 Takayasu Takayasu NNP cord-024189-t7mbsr25 378 12 's 's POS cord-024189-t7mbsr25 378 13 arteritis arteritis NN cord-024189-t7mbsr25 378 14 , , , cord-024189-t7mbsr25 378 15 Henoch Henoch NNP cord-024189-t7mbsr25 378 16 - - HYPH cord-024189-t7mbsr25 378 17 Schönlein Schönlein NNP cord-024189-t7mbsr25 378 18 purpura purpura NN cord-024189-t7mbsr25 378 19 , , , cord-024189-t7mbsr25 378 20 and and CC cord-024189-t7mbsr25 378 21 even even RB cord-024189-t7mbsr25 378 22 PAN PAN NNP cord-024189-t7mbsr25 378 23 itself -PRON- PRP cord-024189-t7mbsr25 378 24 exist exist VBP cord-024189-t7mbsr25 378 25 in in IN cord-024189-t7mbsr25 378 26 the the DT cord-024189-t7mbsr25 378 27 medical medical JJ cord-024189-t7mbsr25 378 28 literature literature NN cord-024189-t7mbsr25 378 29 . . . cord-024189-t7mbsr25 379 1 For for IN cord-024189-t7mbsr25 379 2 nearly nearly RB cord-024189-t7mbsr25 379 3 a a DT cord-024189-t7mbsr25 379 4 century century NN cord-024189-t7mbsr25 379 5 after after IN cord-024189-t7mbsr25 379 6 the the DT cord-024189-t7mbsr25 379 7 case case NN cord-024189-t7mbsr25 379 8 reported report VBN cord-024189-t7mbsr25 379 9 by by IN cord-024189-t7mbsr25 379 10 Kussmaul Kussmaul NNP cord-024189-t7mbsr25 379 11 and and CC cord-024189-t7mbsr25 379 12 Maier Maier NNP cord-024189-t7mbsr25 379 13 , , , cord-024189-t7mbsr25 379 14 however however RB cord-024189-t7mbsr25 379 15 , , , cord-024189-t7mbsr25 379 16 most most JJS cord-024189-t7mbsr25 379 17 forms form NNS cord-024189-t7mbsr25 379 18 of of IN cord-024189-t7mbsr25 379 19 systemic systemic JJ cord-024189-t7mbsr25 379 20 vasculitis vasculitis NN cord-024189-t7mbsr25 379 21 were be VBD cord-024189-t7mbsr25 379 22 termed term VBN cord-024189-t7mbsr25 379 23 periarteritis periarteritis NN cord-024189-t7mbsr25 379 24 nodosa nodosa NN cord-024189-t7mbsr25 379 25 , , , cord-024189-t7mbsr25 379 26 and and CC cord-024189-t7mbsr25 379 27 forms form NNS cord-024189-t7mbsr25 379 28 of of IN cord-024189-t7mbsr25 379 29 vasculitis vasculitis NN cord-024189-t7mbsr25 379 30 recognized recognize VBN cord-024189-t7mbsr25 379 31 later later RB cord-024189-t7mbsr25 379 32 were be VBD cord-024189-t7mbsr25 379 33 contrasted contrast VBN cord-024189-t7mbsr25 379 34 and and CC cord-024189-t7mbsr25 379 35 classifi classifi NNP cord-024189-t7mbsr25 379 36 ed ed NN cord-024189-t7mbsr25 379 37 in in IN cord-024189-t7mbsr25 379 38 comparison comparison NN cord-024189-t7mbsr25 379 39 to to IN cord-024189-t7mbsr25 379 40 PAN PAN NNP cord-024189-t7mbsr25 379 41 . . . cord-024189-t7mbsr25 380 1 The the DT cord-024189-t7mbsr25 380 2 patient patient NN cord-024189-t7mbsr25 380 3 described describe VBN cord-024189-t7mbsr25 380 4 by by IN cord-024189-t7mbsr25 380 5 Kussmaul Kussmaul NNP cord-024189-t7mbsr25 380 6 and and CC cord-024189-t7mbsr25 380 7 Maier Maier NNP cord-024189-t7mbsr25 380 8 was be VBD cord-024189-t7mbsr25 380 9 a a DT cord-024189-t7mbsr25 380 10 27-year 27-year JJ cord-024189-t7mbsr25 380 11 - - HYPH cord-024189-t7mbsr25 380 12 old old JJ cord-024189-t7mbsr25 380 13 male male NN cord-024189-t7mbsr25 380 14 with with IN cord-024189-t7mbsr25 380 15 fever fever NN cord-024189-t7mbsr25 380 16 , , , cord-024189-t7mbsr25 380 17 weight weight NN cord-024189-t7mbsr25 380 18 loss loss NN cord-024189-t7mbsr25 380 19 , , , cord-024189-t7mbsr25 380 20 abdominal abdominal JJ cord-024189-t7mbsr25 380 21 pain pain NN cord-024189-t7mbsr25 380 22 , , , cord-024189-t7mbsr25 380 23 and and CC cord-024189-t7mbsr25 380 24 a a DT cord-024189-t7mbsr25 380 25 polyneuropathy polyneuropathy NN cord-024189-t7mbsr25 380 26 that that WDT cord-024189-t7mbsr25 380 27 progressed progress VBD cord-024189-t7mbsr25 380 28 over over IN cord-024189-t7mbsr25 380 29 the the DT cord-024189-t7mbsr25 380 30 period period NN cord-024189-t7mbsr25 380 31 of of IN cord-024189-t7mbsr25 380 32 1 1 CD cord-024189-t7mbsr25 380 33 month month NN cord-024189-t7mbsr25 380 34 to to IN cord-024189-t7mbsr25 380 35 paralysis paralysis NN cord-024189-t7mbsr25 380 36 . . . cord-024189-t7mbsr25 381 1 An an DT cord-024189-t7mbsr25 381 2 autopsy autopsy NN cord-024189-t7mbsr25 381 3 revealed reveal VBN cord-024189-t7mbsr25 381 4 microaneurysms microaneurysm NNS cord-024189-t7mbsr25 381 5 ( ( -LRB- cord-024189-t7mbsr25 381 6 " " `` cord-024189-t7mbsr25 381 7 whitish whitish JJ cord-024189-t7mbsr25 381 8 small small JJ cord-024189-t7mbsr25 381 9 tumors tumor NNS cord-024189-t7mbsr25 381 10 up up IN cord-024189-t7mbsr25 381 11 to to IN cord-024189-t7mbsr25 381 12 the the DT cord-024189-t7mbsr25 381 13 size size NN cord-024189-t7mbsr25 381 14 of of IN cord-024189-t7mbsr25 381 15 poppy poppy NN cord-024189-t7mbsr25 381 16 and and CC cord-024189-t7mbsr25 381 17 hemp hemp NN cord-024189-t7mbsr25 381 18 seeds seed NNS cord-024189-t7mbsr25 381 19 " " '' cord-024189-t7mbsr25 381 20 ) ) -RRB- cord-024189-t7mbsr25 381 21 throughout throughout IN cord-024189-t7mbsr25 381 22 medium medium JJ cord-024189-t7mbsr25 381 23 - - HYPH cord-024189-t7mbsr25 381 24 sized sized JJ cord-024189-t7mbsr25 381 25 arteries artery NNS cord-024189-t7mbsr25 381 26 , , , cord-024189-t7mbsr25 381 27 conspicuously conspicuously RB cord-024189-t7mbsr25 381 28 sparing spare VBG cord-024189-t7mbsr25 381 29 both both CC cord-024189-t7mbsr25 381 30 the the DT cord-024189-t7mbsr25 381 31 venous venous JJ cord-024189-t7mbsr25 381 32 circulation circulation NN cord-024189-t7mbsr25 381 33 and and CC cord-024189-t7mbsr25 381 34 the the DT cord-024189-t7mbsr25 381 35 lungs lung NNS cord-024189-t7mbsr25 381 36 . . . cord-024189-t7mbsr25 382 1 Before before IN cord-024189-t7mbsr25 382 2 the the DT cord-024189-t7mbsr25 382 3 delineation delineation NN cord-024189-t7mbsr25 382 4 of of IN cord-024189-t7mbsr25 382 5 vasculitis vasculitis NN cord-024189-t7mbsr25 382 6 subsets subset NNS cord-024189-t7mbsr25 382 7 and and CC cord-024189-t7mbsr25 382 8 the the DT cord-024189-t7mbsr25 382 9 formulation formulation NN cord-024189-t7mbsr25 382 10 of of IN cord-024189-t7mbsr25 382 11 defi defi NNP cord-024189-t7mbsr25 382 12 nitions nitions NNP cord-024189-t7mbsr25 382 13 based base VBN cord-024189-t7mbsr25 382 14 principally principally RB cord-024189-t7mbsr25 382 15 on on IN cord-024189-t7mbsr25 382 16 vessel vessel NN cord-024189-t7mbsr25 382 17 size size NN cord-024189-t7mbsr25 382 18 ( ( -LRB- cord-024189-t7mbsr25 382 19 3 3 CD cord-024189-t7mbsr25 382 20 ) ) -RRB- cord-024189-t7mbsr25 382 21 , , , cord-024189-t7mbsr25 382 22 PAN PAN NNP cord-024189-t7mbsr25 382 23 was be VBD cord-024189-t7mbsr25 382 24 used use VBN cord-024189-t7mbsr25 382 25 to to TO cord-024189-t7mbsr25 382 26 describe describe VB cord-024189-t7mbsr25 382 27 two two CD cord-024189-t7mbsr25 382 28 now now RB cord-024189-t7mbsr25 382 29 - - HYPH cord-024189-t7mbsr25 382 30 distinct distinct JJ cord-024189-t7mbsr25 382 31 forms form NNS cord-024189-t7mbsr25 382 32 of of IN cord-024189-t7mbsr25 382 33 vasculitis vasculitis NN cord-024189-t7mbsr25 382 34 : : : cord-024189-t7mbsr25 382 35 the the DT cord-024189-t7mbsr25 382 36 classic classic NNP cord-024189-t7mbsr25 382 37 PAN PAN NNP cord-024189-t7mbsr25 382 38 described describe VBN cord-024189-t7mbsr25 382 39 by by IN cord-024189-t7mbsr25 382 40 Kussmaul Kussmaul NNP cord-024189-t7mbsr25 382 41 and and CC cord-024189-t7mbsr25 382 42 Maier Maier NNP cord-024189-t7mbsr25 382 43 , , , cord-024189-t7mbsr25 382 44 and and CC cord-024189-t7mbsr25 382 45 " " `` cord-024189-t7mbsr25 382 46 microscopic microscopic JJ cord-024189-t7mbsr25 382 47 PAN pan NN cord-024189-t7mbsr25 382 48 " " '' cord-024189-t7mbsr25 382 49 ( ( -LRB- cord-024189-t7mbsr25 382 50 now now RB cord-024189-t7mbsr25 382 51 called call VBN cord-024189-t7mbsr25 382 52 microscopic microscopic JJ cord-024189-t7mbsr25 382 53 polyangiitis polyangiitis NN cord-024189-t7mbsr25 382 54 ) ) -RRB- cord-024189-t7mbsr25 382 55 . . . cord-024189-t7mbsr25 383 1 According accord VBG cord-024189-t7mbsr25 383 2 to to IN cord-024189-t7mbsr25 383 3 current current JJ cord-024189-t7mbsr25 383 4 convention convention NN cord-024189-t7mbsr25 383 5 , , , cord-024189-t7mbsr25 383 6 and and CC cord-024189-t7mbsr25 383 7 as as IN cord-024189-t7mbsr25 383 8 described describe VBN cord-024189-t7mbsr25 383 9 in in IN cord-024189-t7mbsr25 383 10 this this DT cord-024189-t7mbsr25 383 11 text text NN cord-024189-t7mbsr25 383 12 , , , cord-024189-t7mbsr25 383 13 PAN PAN NNP cord-024189-t7mbsr25 383 14 is be VBZ cord-024189-t7mbsr25 383 15 a a DT cord-024189-t7mbsr25 383 16 vasculitis vasculitis NN cord-024189-t7mbsr25 383 17 affecting affect VBG cord-024189-t7mbsr25 383 18 medium medium NN cord-024189-t7mbsr25 383 19 - - HYPH cord-024189-t7mbsr25 383 20 sized sized JJ cord-024189-t7mbsr25 383 21 arteries artery NNS cord-024189-t7mbsr25 383 22 . . . cord-024189-t7mbsr25 384 1 PAN PAN NNP cord-024189-t7mbsr25 384 2 is be VBZ cord-024189-t7mbsr25 384 3 also also RB cord-024189-t7mbsr25 384 4 not not RB cord-024189-t7mbsr25 384 5 associated associate VBN cord-024189-t7mbsr25 384 6 with with IN cord-024189-t7mbsr25 384 7 antineutrophil antineutrophil JJ cord-024189-t7mbsr25 384 8 cytoplasmic cytoplasmic JJ cord-024189-t7mbsr25 384 9 antibodies antibody NNS cord-024189-t7mbsr25 384 10 ( ( -LRB- cord-024189-t7mbsr25 384 11 ANCA ANCA NNP cord-024189-t7mbsr25 384 12 ) ) -RRB- cord-024189-t7mbsr25 384 13 , , , cord-024189-t7mbsr25 384 14 at at IN cord-024189-t7mbsr25 384 15 least least JJS cord-024189-t7mbsr25 384 16 not not RB cord-024189-t7mbsr25 384 17 those those DT cord-024189-t7mbsr25 384 18 directed direct VBN cord-024189-t7mbsr25 384 19 against against IN cord-024189-t7mbsr25 384 20 proteinase-3 proteinase-3 NNP cord-024189-t7mbsr25 384 21 ( ( -LRB- cord-024189-t7mbsr25 384 22 PR3 PR3 NNP cord-024189-t7mbsr25 384 23 ) ) -RRB- cord-024189-t7mbsr25 384 24 or or CC cord-024189-t7mbsr25 384 25 myeloperoxidase myeloperoxidase NNP cord-024189-t7mbsr25 384 26 ( ( -LRB- cord-024189-t7mbsr25 384 27 MPO MPO NNP cord-024189-t7mbsr25 384 28 ) ) -RRB- cord-024189-t7mbsr25 384 29 that that WDT cord-024189-t7mbsr25 384 30 are be VBP cord-024189-t7mbsr25 384 31 such such PDT cord-024189-t7mbsr25 384 32 a a DT cord-024189-t7mbsr25 384 33 distinctive distinctive JJ cord-024189-t7mbsr25 384 34 feature feature NN cord-024189-t7mbsr25 384 35 of of IN cord-024189-t7mbsr25 384 36 the the DT cord-024189-t7mbsr25 384 37 majority majority NN cord-024189-t7mbsr25 384 38 of of IN cord-024189-t7mbsr25 384 39 cases case NNS cord-024189-t7mbsr25 384 40 of of IN cord-024189-t7mbsr25 384 41 Wegener Wegener NNP cord-024189-t7mbsr25 384 42 's 's POS cord-024189-t7mbsr25 384 43 granulomatosis granulomatosis NN cord-024189-t7mbsr25 384 44 , , , cord-024189-t7mbsr25 384 45 microscopic microscopic JJ cord-024189-t7mbsr25 384 46 polyangiitis polyangiitis NN cord-024189-t7mbsr25 384 47 , , , cord-024189-t7mbsr25 384 48 and and CC cord-024189-t7mbsr25 384 49 , , , cord-024189-t7mbsr25 384 50 to to IN cord-024189-t7mbsr25 384 51 a a DT cord-024189-t7mbsr25 384 52 lesser less JJR cord-024189-t7mbsr25 384 53 extent extent NN cord-024189-t7mbsr25 384 54 , , , cord-024189-t7mbsr25 384 55 the the DT cord-024189-t7mbsr25 384 56 Churg Churg NNP cord-024189-t7mbsr25 384 57 - - HYPH cord-024189-t7mbsr25 384 58 Strauss Strauss NNP cord-024189-t7mbsr25 384 59 syndrome syndrome NN cord-024189-t7mbsr25 384 60 . . . cord-024189-t7mbsr25 385 1 Although although IN cord-024189-t7mbsr25 385 2 patients patient NNS cord-024189-t7mbsr25 385 3 may may MD cord-024189-t7mbsr25 385 4 be be VB cord-024189-t7mbsr25 385 5 P p NN cord-024189-t7mbsr25 385 6 - - HYPH cord-024189-t7mbsr25 385 7 ANCA ANCA NNP cord-024189-t7mbsr25 385 8 - - HYPH cord-024189-t7mbsr25 385 9 positive positive JJ cord-024189-t7mbsr25 385 10 on on IN cord-024189-t7mbsr25 385 11 immunofl immunofl NN cord-024189-t7mbsr25 385 12 uorescence uorescence NN cord-024189-t7mbsr25 385 13 testing testing NN cord-024189-t7mbsr25 385 14 , , , cord-024189-t7mbsr25 385 15 enzyme enzyme NNP cord-024189-t7mbsr25 385 16 immunoassays immunoassays NNP cord-024189-t7mbsr25 385 17 for for IN cord-024189-t7mbsr25 385 18 PR3-and PR3-and NNP cord-024189-t7mbsr25 386 1 MPO MPO NNP cord-024189-t7mbsr25 386 2 - - HYPH cord-024189-t7mbsr25 386 3 ANCA ANCA NNP cord-024189-t7mbsr25 386 4 are be VBP cord-024189-t7mbsr25 386 5 negative negative JJ cord-024189-t7mbsr25 386 6 in in IN cord-024189-t7mbsr25 386 7 PAN PAN NNP cord-024189-t7mbsr25 386 8 . . . cord-024189-t7mbsr25 387 1 Further further RB cord-024189-t7mbsr25 387 2 , , , cord-024189-t7mbsr25 387 3 in in IN cord-024189-t7mbsr25 387 4 contrast contrast NN cord-024189-t7mbsr25 387 5 to to IN cord-024189-t7mbsr25 387 6 the the DT cord-024189-t7mbsr25 387 7 ANCA ANCA NNP cord-024189-t7mbsr25 387 8 - - HYPH cord-024189-t7mbsr25 387 9 associated associate VBN cord-024189-t7mbsr25 387 10 vasculitides vasculitide NNS cord-024189-t7mbsr25 387 11 ( ( -LRB- cord-024189-t7mbsr25 387 12 see see VB cord-024189-t7mbsr25 387 13 Chapter Chapter NNP cord-024189-t7mbsr25 387 14 21C 21C NNP cord-024189-t7mbsr25 387 15 ) ) -RRB- cord-024189-t7mbsr25 387 16 , , , cord-024189-t7mbsr25 387 17 PAN PAN NNP cord-024189-t7mbsr25 387 18 does do VBZ cord-024189-t7mbsr25 387 19 not not RB cord-024189-t7mbsr25 387 20 involve involve VB cord-024189-t7mbsr25 387 21 either either CC cord-024189-t7mbsr25 387 22 the the DT cord-024189-t7mbsr25 387 23 lungs lung NNS cord-024189-t7mbsr25 387 24 or or CC cord-024189-t7mbsr25 387 25 blood blood NN cord-024189-t7mbsr25 387 26 vessels vessel NNS cord-024189-t7mbsr25 387 27 as as RB cord-024189-t7mbsr25 387 28 small small JJ cord-024189-t7mbsr25 387 29 as as IN cord-024189-t7mbsr25 387 30 the the DT cord-024189-t7mbsr25 387 31 renal renal JJ cord-024189-t7mbsr25 387 32 glomeruli glomerulus NNS cord-024189-t7mbsr25 387 33 ( ( -LRB- cord-024189-t7mbsr25 387 34 which which WDT cord-024189-t7mbsr25 387 35 are be VBP cord-024189-t7mbsr25 387 36 essentially essentially RB cord-024189-t7mbsr25 387 37 capillaries capillary NNS cord-024189-t7mbsr25 387 38 ) ) -RRB- cord-024189-t7mbsr25 387 39 . . . cord-024189-t7mbsr25 388 1 Polyarteritis Polyarteritis NNP cord-024189-t7mbsr25 388 2 nodosa nodosa RB cord-024189-t7mbsr25 388 3 affects affect VBZ cord-024189-t7mbsr25 388 4 men man NNS cord-024189-t7mbsr25 388 5 and and CC cord-024189-t7mbsr25 388 6 women woman NNS cord-024189-t7mbsr25 388 7 approximately approximately RB cord-024189-t7mbsr25 388 8 equally equally RB cord-024189-t7mbsr25 388 9 and and CC cord-024189-t7mbsr25 388 10 has have VBZ cord-024189-t7mbsr25 388 11 a a DT cord-024189-t7mbsr25 388 12 broad broad JJ cord-024189-t7mbsr25 388 13 age age NN cord-024189-t7mbsr25 388 14 range range NN cord-024189-t7mbsr25 388 15 of of IN cord-024189-t7mbsr25 388 16 patients patient NNS cord-024189-t7mbsr25 388 17 . . . cord-024189-t7mbsr25 389 1 Although although IN cord-024189-t7mbsr25 389 2 the the DT cord-024189-t7mbsr25 389 3 incidence incidence NN cord-024189-t7mbsr25 389 4 of of IN cord-024189-t7mbsr25 389 5 PAN PAN NNP cord-024189-t7mbsr25 389 6 varies vary VBZ cord-024189-t7mbsr25 389 7 according accord VBG cord-024189-t7mbsr25 389 8 to to IN cord-024189-t7mbsr25 389 9 the the DT cord-024189-t7mbsr25 389 10 population population NN cord-024189-t7mbsr25 389 11 studied study VBD cord-024189-t7mbsr25 389 12 , , , cord-024189-t7mbsr25 389 13 it -PRON- PRP cord-024189-t7mbsr25 389 14 is be VBZ cord-024189-t7mbsr25 389 15 rare rare JJ cord-024189-t7mbsr25 389 16 in in IN cord-024189-t7mbsr25 389 17 all all DT cord-024189-t7mbsr25 389 18 populations population NNS cord-024189-t7mbsr25 389 19 , , , cord-024189-t7mbsr25 389 20 with with IN cord-024189-t7mbsr25 389 21 annual annual JJ cord-024189-t7mbsr25 389 22 incidence incidence NN cord-024189-t7mbsr25 389 23 rates rate NNS cord-024189-t7mbsr25 389 24 generally generally RB cord-024189-t7mbsr25 389 25 ranging range VBG cord-024189-t7mbsr25 389 26 from from IN cord-024189-t7mbsr25 389 27 2 2 CD cord-024189-t7mbsr25 389 28 to to TO cord-024189-t7mbsr25 389 29 9 9 CD cord-024189-t7mbsr25 389 30 cases case NNS cord-024189-t7mbsr25 389 31 per per IN cord-024189-t7mbsr25 389 32 million million CD cord-024189-t7mbsr25 389 33 . . . cord-024189-t7mbsr25 390 1 Higher high JJR cord-024189-t7mbsr25 390 2 rates rate NNS cord-024189-t7mbsr25 390 3 have have VBP cord-024189-t7mbsr25 390 4 been be VBN cord-024189-t7mbsr25 390 5 reported report VBN cord-024189-t7mbsr25 390 6 in in IN cord-024189-t7mbsr25 390 7 populations population NNS cord-024189-t7mbsr25 390 8 with with IN cord-024189-t7mbsr25 390 9 a a DT cord-024189-t7mbsr25 390 10 high high JJ cord-024189-t7mbsr25 390 11 burden burden NN cord-024189-t7mbsr25 390 12 of of IN cord-024189-t7mbsr25 390 13 hepatitis hepatitis NN cord-024189-t7mbsr25 390 14 B B NNP cord-024189-t7mbsr25 390 15 virus virus NN cord-024189-t7mbsr25 390 16 infection infection NN cord-024189-t7mbsr25 390 17 , , , cord-024189-t7mbsr25 390 18 but but CC cord-024189-t7mbsr25 390 19 with with IN cord-024189-t7mbsr25 390 20 the the DT cord-024189-t7mbsr25 390 21 availability availability NN cord-024189-t7mbsr25 390 22 of of IN cord-024189-t7mbsr25 390 23 a a DT cord-024189-t7mbsr25 390 24 vaccine vaccine NN cord-024189-t7mbsr25 390 25 , , , cord-024189-t7mbsr25 390 26 hepatitis hepatitis NNP cord-024189-t7mbsr25 390 27 B B NNP cord-024189-t7mbsr25 390 28 virus virus NN cord-024189-t7mbsr25 390 29 infection infection NN cord-024189-t7mbsr25 390 30 now now RB cord-024189-t7mbsr25 390 31 accounts account VBZ cord-024189-t7mbsr25 390 32 for for IN cord-024189-t7mbsr25 390 33 less less JJR cord-024189-t7mbsr25 390 34 than than IN cord-024189-t7mbsr25 390 35 10 10 CD cord-024189-t7mbsr25 390 36 % % NN cord-024189-t7mbsr25 390 37 of of IN cord-024189-t7mbsr25 390 38 PAN PAN NNP cord-024189-t7mbsr25 390 39 cases case NNS cord-024189-t7mbsr25 390 40 in in IN cord-024189-t7mbsr25 390 41 developed develop VBN cord-024189-t7mbsr25 390 42 countries country NNS cord-024189-t7mbsr25 390 43 ( ( -LRB- cord-024189-t7mbsr25 390 44 4 4 CD cord-024189-t7mbsr25 390 45 ) ) -RRB- cord-024189-t7mbsr25 390 46 . . . cord-024189-t7mbsr25 391 1 PAN PAN NNP cord-024189-t7mbsr25 391 2 has have VBZ cord-024189-t7mbsr25 391 3 also also RB cord-024189-t7mbsr25 391 4 been be VBN cord-024189-t7mbsr25 391 5 reported report VBN cord-024189-t7mbsr25 391 6 to to TO cord-024189-t7mbsr25 391 7 occur occur VB cord-024189-t7mbsr25 391 8 in in IN cord-024189-t7mbsr25 391 9 conjunction conjunction NN cord-024189-t7mbsr25 391 10 with with IN cord-024189-t7mbsr25 391 11 hairy hairy JJ cord-024189-t7mbsr25 391 12 cell cell NN cord-024189-t7mbsr25 391 13 leukemia leukemia NN cord-024189-t7mbsr25 391 14 . . . cord-024189-t7mbsr25 392 1 Polyarteritis Polyarteritis NNP cord-024189-t7mbsr25 392 2 nodosa nodosa RB cord-024189-t7mbsr25 392 3 can can MD cord-024189-t7mbsr25 392 4 present present VB cord-024189-t7mbsr25 392 5 with with IN cord-024189-t7mbsr25 392 6 nonspecifi nonspecifi NNP cord-024189-t7mbsr25 392 7 c c NN cord-024189-t7mbsr25 392 8 constitutional constitutional JJ cord-024189-t7mbsr25 392 9 symptoms symptom NNS cord-024189-t7mbsr25 392 10 such such JJ cord-024189-t7mbsr25 392 11 as as IN cord-024189-t7mbsr25 392 12 fever fever NN cord-024189-t7mbsr25 392 13 , , , cord-024189-t7mbsr25 392 14 fatigue fatigue NN cord-024189-t7mbsr25 392 15 , , , cord-024189-t7mbsr25 392 16 malaise malaise NN cord-024189-t7mbsr25 392 17 , , , cord-024189-t7mbsr25 392 18 myalgias myalgias NNP cord-024189-t7mbsr25 392 19 , , , cord-024189-t7mbsr25 392 20 and and CC cord-024189-t7mbsr25 392 21 arthralgias arthralgias NNP cord-024189-t7mbsr25 392 22 . . . cord-024189-t7mbsr25 393 1 This this DT cord-024189-t7mbsr25 393 2 phase phase NN cord-024189-t7mbsr25 393 3 of of IN cord-024189-t7mbsr25 393 4 the the DT cord-024189-t7mbsr25 393 5 illness illness NN cord-024189-t7mbsr25 393 6 can can MD cord-024189-t7mbsr25 393 7 last last VB cord-024189-t7mbsr25 393 8 weeks week NNS cord-024189-t7mbsr25 393 9 or or CC cord-024189-t7mbsr25 393 10 months month NNS cord-024189-t7mbsr25 393 11 . . . cord-024189-t7mbsr25 394 1 The the DT cord-024189-t7mbsr25 394 2 more more RBR cord-024189-t7mbsr25 394 3 specifi specifi JJ cord-024189-t7mbsr25 394 4 c c NN cord-024189-t7mbsr25 394 5 clinical clinical JJ cord-024189-t7mbsr25 394 6 manifestations manifestation NNS cord-024189-t7mbsr25 394 7 of of IN cord-024189-t7mbsr25 394 8 PAN PAN NNP cord-024189-t7mbsr25 394 9 are be VBP cord-024189-t7mbsr25 394 10 the the DT cord-024189-t7mbsr25 394 11 direct direct JJ cord-024189-t7mbsr25 394 12 results result NNS cord-024189-t7mbsr25 394 13 of of IN cord-024189-t7mbsr25 394 14 infl infl NN cord-024189-t7mbsr25 394 15 ammation ammation NN cord-024189-t7mbsr25 394 16 in in IN cord-024189-t7mbsr25 394 17 medium medium NN cord-024189-t7mbsr25 394 18 - - HYPH cord-024189-t7mbsr25 394 19 and and CC cord-024189-t7mbsr25 394 20 small small JJ cord-024189-t7mbsr25 394 21 - - HYPH cord-024189-t7mbsr25 394 22 sized sized JJ cord-024189-t7mbsr25 394 23 muscular muscular JJ cord-024189-t7mbsr25 394 24 arteries artery NNS cord-024189-t7mbsr25 394 25 . . . cord-024189-t7mbsr25 395 1 PAN PAN NNP cord-024189-t7mbsr25 395 2 often often RB cord-024189-t7mbsr25 395 3 has have VBZ cord-024189-t7mbsr25 395 4 cutaneous cutaneous JJ cord-024189-t7mbsr25 395 5 involvement involvement NN cord-024189-t7mbsr25 395 6 , , , cord-024189-t7mbsr25 395 7 a a DT cord-024189-t7mbsr25 395 8 feature feature NN cord-024189-t7mbsr25 395 9 it -PRON- PRP cord-024189-t7mbsr25 395 10 shares share VBZ cord-024189-t7mbsr25 395 11 with with IN cord-024189-t7mbsr25 395 12 small small JJ cord-024189-t7mbsr25 395 13 vessel vessel NN cord-024189-t7mbsr25 395 14 vasculitides vasculitide NNS cord-024189-t7mbsr25 395 15 such such JJ cord-024189-t7mbsr25 395 16 as as IN cord-024189-t7mbsr25 395 17 the the DT cord-024189-t7mbsr25 395 18 ANCAassociated ancaassociate VBN cord-024189-t7mbsr25 395 19 disorders disorder NNS cord-024189-t7mbsr25 395 20 . . . cord-024189-t7mbsr25 396 1 This this DT cord-024189-t7mbsr25 396 2 differentiates differentiate VBZ cord-024189-t7mbsr25 396 3 it -PRON- PRP cord-024189-t7mbsr25 396 4 from from IN cord-024189-t7mbsr25 396 5 large large JJ cord-024189-t7mbsr25 396 6 vessel vessel NN cord-024189-t7mbsr25 396 7 vasculitis vasculitis NN cord-024189-t7mbsr25 396 8 ( ( -LRB- cord-024189-t7mbsr25 396 9 e.g. e.g. RB cord-024189-t7mbsr25 396 10 , , , cord-024189-t7mbsr25 396 11 giant giant JJ cord-024189-t7mbsr25 396 12 cell cell NN cord-024189-t7mbsr25 396 13 arteritis arteritis NN cord-024189-t7mbsr25 396 14 and and CC cord-024189-t7mbsr25 396 15 Takayasu Takayasu NNP cord-024189-t7mbsr25 396 16 's 's POS cord-024189-t7mbsr25 396 17 arteritis arteritis NN cord-024189-t7mbsr25 396 18 ) ) -RRB- cord-024189-t7mbsr25 396 19 , , , cord-024189-t7mbsr25 396 20 in in IN cord-024189-t7mbsr25 396 21 which which WDT cord-024189-t7mbsr25 396 22 skin skin NN cord-024189-t7mbsr25 396 23 disease disease NN cord-024189-t7mbsr25 396 24 is be VBZ cord-024189-t7mbsr25 396 25 very very RB cord-024189-t7mbsr25 396 26 rare rare JJ cord-024189-t7mbsr25 396 27 . . . cord-024189-t7mbsr25 397 1 However however RB cord-024189-t7mbsr25 397 2 , , , cord-024189-t7mbsr25 397 3 unlike unlike IN cord-024189-t7mbsr25 397 4 the the DT cord-024189-t7mbsr25 397 5 ANCA ANCA NNP cord-024189-t7mbsr25 397 6 - - HYPH cord-024189-t7mbsr25 397 7 associated associate VBN cord-024189-t7mbsr25 397 8 vasculitides vasculitide NNS cord-024189-t7mbsr25 397 9 , , , cord-024189-t7mbsr25 397 10 PAN PAN NNP cord-024189-t7mbsr25 397 11 is be VBZ cord-024189-t7mbsr25 397 12 not not RB cord-024189-t7mbsr25 397 13 associated associate VBN cord-024189-t7mbsr25 397 14 with with IN cord-024189-t7mbsr25 397 15 glomerulonephritis glomerulonephritis NN cord-024189-t7mbsr25 397 16 or or CC cord-024189-t7mbsr25 397 17 pulmonary pulmonary JJ cord-024189-t7mbsr25 397 18 involvement involvement NN cord-024189-t7mbsr25 397 19 . . . cord-024189-t7mbsr25 398 1 Common common JJ cord-024189-t7mbsr25 398 2 clinical clinical JJ cord-024189-t7mbsr25 398 3 features feature NNS cord-024189-t7mbsr25 398 4 of of IN cord-024189-t7mbsr25 398 5 PAN PAN NNP cord-024189-t7mbsr25 398 6 and and CC cord-024189-t7mbsr25 398 7 their -PRON- PRP$ cord-024189-t7mbsr25 398 8 frequency frequency NN cord-024189-t7mbsr25 398 9 are be VBP cord-024189-t7mbsr25 398 10 listed list VBN cord-024189-t7mbsr25 398 11 in in IN cord-024189-t7mbsr25 398 12 Table Table NNP cord-024189-t7mbsr25 398 13 21B 21b NN cord-024189-t7mbsr25 398 14 -1 -1 . cord-024189-t7mbsr25 399 1 ( ( -LRB- cord-024189-t7mbsr25 399 2 5 5 LS cord-024189-t7mbsr25 399 3 ) ) -RRB- cord-024189-t7mbsr25 399 4 . . . cord-024189-t7mbsr25 400 1 In in IN cord-024189-t7mbsr25 400 2 autopsy autopsy JJ cord-024189-t7mbsr25 400 3 studies study NNS cord-024189-t7mbsr25 400 4 , , , cord-024189-t7mbsr25 400 5 the the DT cord-024189-t7mbsr25 400 6 most most RBS cord-024189-t7mbsr25 400 7 frequently frequently RB cord-024189-t7mbsr25 400 8 involved involve VBN cord-024189-t7mbsr25 400 9 organ organ NN cord-024189-t7mbsr25 400 10 in in IN cord-024189-t7mbsr25 400 11 PAN PAN NNP cord-024189-t7mbsr25 400 12 is be VBZ cord-024189-t7mbsr25 400 13 the the DT cord-024189-t7mbsr25 400 14 kidney kidney NN cord-024189-t7mbsr25 400 15 . . . cord-024189-t7mbsr25 401 1 Involvement involvement NN cord-024189-t7mbsr25 401 2 of of IN cord-024189-t7mbsr25 401 3 the the DT cord-024189-t7mbsr25 401 4 mediumsized mediumsized JJ cord-024189-t7mbsr25 401 5 arteries artery NNS cord-024189-t7mbsr25 401 6 supplying supply VBG cord-024189-t7mbsr25 401 7 the the DT cord-024189-t7mbsr25 401 8 renal renal JJ cord-024189-t7mbsr25 401 9 parenchyma parenchyma NN cord-024189-t7mbsr25 401 10 can can MD cord-024189-t7mbsr25 401 11 result result VB cord-024189-t7mbsr25 401 12 in in IN cord-024189-t7mbsr25 401 13 hypertension hypertension NN cord-024189-t7mbsr25 401 14 due due IN cord-024189-t7mbsr25 401 15 to to IN cord-024189-t7mbsr25 401 16 renal renal JJ cord-024189-t7mbsr25 401 17 ischemia ischemia NN cord-024189-t7mbsr25 401 18 ; ; : cord-024189-t7mbsr25 401 19 hypertension hypertension NN cord-024189-t7mbsr25 401 20 is be VBZ cord-024189-t7mbsr25 401 21 mediated mediate VBN cord-024189-t7mbsr25 401 22 by by IN cord-024189-t7mbsr25 401 23 the the DT cord-024189-t7mbsr25 401 24 renin renin NN cord-024189-t7mbsr25 401 25 - - HYPH cord-024189-t7mbsr25 401 26 angiotensin angiotensin NN cord-024189-t7mbsr25 401 27 system system NN cord-024189-t7mbsr25 401 28 . . . cord-024189-t7mbsr25 402 1 Renal renal JJ cord-024189-t7mbsr25 402 2 insuffi insuffi NNP cord-024189-t7mbsr25 402 3 ciency ciency NNP cord-024189-t7mbsr25 402 4 , , , cord-024189-t7mbsr25 402 5 another another DT cord-024189-t7mbsr25 402 6 common common JJ cord-024189-t7mbsr25 402 7 manifestation manifestation NN cord-024189-t7mbsr25 402 8 of of IN cord-024189-t7mbsr25 402 9 PAN PAN NNP cord-024189-t7mbsr25 402 10 , , , cord-024189-t7mbsr25 402 11 is be VBZ cord-024189-t7mbsr25 402 12 due due JJ cord-024189-t7mbsr25 402 13 to to IN cord-024189-t7mbsr25 402 14 ischemia ischemia NN cord-024189-t7mbsr25 402 15 resulting result VBG cord-024189-t7mbsr25 402 16 from from IN cord-024189-t7mbsr25 402 17 the the DT cord-024189-t7mbsr25 402 18 involvement involvement NN cord-024189-t7mbsr25 402 19 of of IN cord-024189-t7mbsr25 402 20 arteries artery NNS cord-024189-t7mbsr25 402 21 the the DT cord-024189-t7mbsr25 402 22 size size NN cord-024189-t7mbsr25 402 23 of of IN cord-024189-t7mbsr25 402 24 renal renal JJ cord-024189-t7mbsr25 402 25 arteries artery NNS cord-024189-t7mbsr25 402 26 and and CC cord-024189-t7mbsr25 402 27 smaller small JJR cord-024189-t7mbsr25 402 28 . . . cord-024189-t7mbsr25 403 1 Microaneurysms Microaneurysms NNP cord-024189-t7mbsr25 403 2 , , , cord-024189-t7mbsr25 403 3 detectable detectable JJ cord-024189-t7mbsr25 403 4 by by IN cord-024189-t7mbsr25 403 5 angiography angiography NN cord-024189-t7mbsr25 403 6 [ [ -LRB- cord-024189-t7mbsr25 403 7 Figure figure NN cord-024189-t7mbsr25 403 8 21B 21b NN cord-024189-t7mbsr25 403 9 -1(A -1(a NN cord-024189-t7mbsr25 403 10 , , , cord-024189-t7mbsr25 403 11 B b NN cord-024189-t7mbsr25 403 12 ) ) -RRB- cord-024189-t7mbsr25 403 13 ] ] -RRB- cord-024189-t7mbsr25 403 14 , , , cord-024189-t7mbsr25 403 15 are be VBP cord-024189-t7mbsr25 403 16 a a DT cord-024189-t7mbsr25 403 17 hallmark hallmark NN cord-024189-t7mbsr25 403 18 of of IN cord-024189-t7mbsr25 403 19 PAN PAN NNP cord-024189-t7mbsr25 403 20 . . . cord-024189-t7mbsr25 404 1 The the DT cord-024189-t7mbsr25 404 2 gastrointestinal gastrointestinal JJ cord-024189-t7mbsr25 404 3 ( ( -LRB- cord-024189-t7mbsr25 404 4 GI GI NNP cord-024189-t7mbsr25 404 5 ) ) -RRB- cord-024189-t7mbsr25 404 6 tract tract NN cord-024189-t7mbsr25 404 7 is be VBZ cord-024189-t7mbsr25 404 8 involved involve VBN cord-024189-t7mbsr25 404 9 in in IN cord-024189-t7mbsr25 404 10 up up IN cord-024189-t7mbsr25 404 11 to to TO cord-024189-t7mbsr25 404 12 50 50 CD cord-024189-t7mbsr25 404 13 % % NN cord-024189-t7mbsr25 404 14 of of IN cord-024189-t7mbsr25 404 15 patients patient NNS cord-024189-t7mbsr25 404 16 . . . cord-024189-t7mbsr25 405 1 Postprandial postprandial JJ cord-024189-t7mbsr25 405 2 periumbilical periumbilical JJ cord-024189-t7mbsr25 405 3 pain pain NN cord-024189-t7mbsr25 405 4 , , , cord-024189-t7mbsr25 405 5 or or CC cord-024189-t7mbsr25 405 6 intestinal intestinal JJ cord-024189-t7mbsr25 405 7 angina angina NN cord-024189-t7mbsr25 405 8 , , , cord-024189-t7mbsr25 405 9 is be VBZ cord-024189-t7mbsr25 405 10 the the DT cord-024189-t7mbsr25 405 11 result result NN cord-024189-t7mbsr25 405 12 of of IN cord-024189-t7mbsr25 405 13 mesenteric mesenteric JJ cord-024189-t7mbsr25 405 14 ischemia ischemia NN cord-024189-t7mbsr25 405 15 . . . cord-024189-t7mbsr25 406 1 More more RBR cord-024189-t7mbsr25 406 2 severe severe JJ cord-024189-t7mbsr25 406 3 disease disease NN cord-024189-t7mbsr25 406 4 can can MD cord-024189-t7mbsr25 406 5 result result VB cord-024189-t7mbsr25 406 6 in in IN cord-024189-t7mbsr25 406 7 bowel bowel NN cord-024189-t7mbsr25 406 8 infarction infarction NN cord-024189-t7mbsr25 406 9 and and CC cord-024189-t7mbsr25 406 10 perforation perforation NN cord-024189-t7mbsr25 406 11 . . . cord-024189-t7mbsr25 407 1 Other other JJ cord-024189-t7mbsr25 407 2 GI GI NNP cord-024189-t7mbsr25 407 3 symptoms symptom NNS cord-024189-t7mbsr25 407 4 can can MD cord-024189-t7mbsr25 407 5 include include VB cord-024189-t7mbsr25 407 6 nausea nausea NN cord-024189-t7mbsr25 407 7 , , , cord-024189-t7mbsr25 407 8 vomiting vomiting NN cord-024189-t7mbsr25 407 9 , , , cord-024189-t7mbsr25 407 10 diarrhea diarrhea NN cord-024189-t7mbsr25 407 11 , , , cord-024189-t7mbsr25 407 12 and and CC cord-024189-t7mbsr25 407 13 bleeding bleed VBG cord-024189-t7mbsr25 407 14 . . . cord-024189-t7mbsr25 408 1 While while IN cord-024189-t7mbsr25 408 2 the the DT cord-024189-t7mbsr25 408 3 small small JJ cord-024189-t7mbsr25 408 4 intestine intestine NN cord-024189-t7mbsr25 408 5 is be VBZ cord-024189-t7mbsr25 408 6 most most RBS cord-024189-t7mbsr25 408 7 commonly commonly RB cord-024189-t7mbsr25 408 8 involved involve VBN cord-024189-t7mbsr25 408 9 , , , cord-024189-t7mbsr25 408 10 rare rare JJ cord-024189-t7mbsr25 408 11 presentations presentation NNS cord-024189-t7mbsr25 408 12 involving involve VBG cord-024189-t7mbsr25 408 13 ischemia ischemia NN cord-024189-t7mbsr25 408 14 of of IN cord-024189-t7mbsr25 408 15 the the DT cord-024189-t7mbsr25 408 16 gallbladder gallbladder NN cord-024189-t7mbsr25 408 17 or or CC cord-024189-t7mbsr25 408 18 appendix appendix NN cord-024189-t7mbsr25 408 19 have have VBP cord-024189-t7mbsr25 408 20 been be VBN cord-024189-t7mbsr25 408 21 described describe VBN cord-024189-t7mbsr25 408 22 ( ( -LRB- cord-024189-t7mbsr25 408 23 6 6 CD cord-024189-t7mbsr25 408 24 ) ) -RRB- cord-024189-t7mbsr25 408 25 . . . cord-024189-t7mbsr25 409 1 Moderately moderately RB cord-024189-t7mbsr25 409 2 elevated elevated JJ cord-024189-t7mbsr25 409 3 hepatic hepatic JJ cord-024189-t7mbsr25 409 4 transaminases transaminase NNS cord-024189-t7mbsr25 409 5 often often RB cord-024189-t7mbsr25 409 6 betray betray VBP cord-024189-t7mbsr25 409 7 liver liver NN cord-024189-t7mbsr25 409 8 involvement involvement NN cord-024189-t7mbsr25 409 9 . . . cord-024189-t7mbsr25 410 1 Asymptomatic asymptomatic JJ cord-024189-t7mbsr25 410 2 mircoaneurysms mircoaneurysm NNS cord-024189-t7mbsr25 410 3 within within IN cord-024189-t7mbsr25 410 4 the the DT cord-024189-t7mbsr25 410 5 liver liver NN cord-024189-t7mbsr25 410 6 are be VBP cord-024189-t7mbsr25 410 7 common common JJ cord-024189-t7mbsr25 410 8 ; ; : cord-024189-t7mbsr25 410 9 these these DT cord-024189-t7mbsr25 410 10 occasionally occasionally RB cord-024189-t7mbsr25 410 11 rupture rupture VBP cord-024189-t7mbsr25 410 12 . . . cord-024189-t7mbsr25 411 1 Involvement involvement NN cord-024189-t7mbsr25 411 2 of of IN cord-024189-t7mbsr25 411 3 the the DT cord-024189-t7mbsr25 411 4 peripheral peripheral JJ cord-024189-t7mbsr25 411 5 nervous nervous JJ cord-024189-t7mbsr25 411 6 system system NN cord-024189-t7mbsr25 411 7 is be VBZ cord-024189-t7mbsr25 411 8 seen see VBN cord-024189-t7mbsr25 411 9 in in IN cord-024189-t7mbsr25 411 10 50 50 CD cord-024189-t7mbsr25 411 11 % % NN cord-024189-t7mbsr25 411 12 to to TO cord-024189-t7mbsr25 411 13 75 75 CD cord-024189-t7mbsr25 411 14 % % NN cord-024189-t7mbsr25 411 15 of of IN cord-024189-t7mbsr25 411 16 patients patient NNS cord-024189-t7mbsr25 411 17 , , , cord-024189-t7mbsr25 411 18 usually usually RB cord-024189-t7mbsr25 411 19 as as IN cord-024189-t7mbsr25 411 20 an an DT cord-024189-t7mbsr25 411 21 asymmetric asymmetric JJ cord-024189-t7mbsr25 411 22 sensory sensory NN cord-024189-t7mbsr25 411 23 and and CC cord-024189-t7mbsr25 411 24 motor motor NN cord-024189-t7mbsr25 411 25 neuropathy neuropathy NN cord-024189-t7mbsr25 411 26 due due IN cord-024189-t7mbsr25 411 27 to to IN cord-024189-t7mbsr25 411 28 ischemia ischemia NN cord-024189-t7mbsr25 411 29 of of IN cord-024189-t7mbsr25 411 30 peripheral peripheral JJ cord-024189-t7mbsr25 411 31 nerves nerve NNS cord-024189-t7mbsr25 411 32 ( ( -LRB- cord-024189-t7mbsr25 411 33 7 7 CD cord-024189-t7mbsr25 411 34 ) ) -RRB- cord-024189-t7mbsr25 411 35 . . . cord-024189-t7mbsr25 412 1 Infarction infarction NN cord-024189-t7mbsr25 412 2 of of IN cord-024189-t7mbsr25 412 3 named name VBN cord-024189-t7mbsr25 412 4 nerves nerve NNS cord-024189-t7mbsr25 412 5 results result NNS cord-024189-t7mbsr25 412 6 in in IN cord-024189-t7mbsr25 412 7 mononeuritis mononeuritis NN cord-024189-t7mbsr25 412 8 multiplex multiplex NN cord-024189-t7mbsr25 412 9 ( ( -LRB- cord-024189-t7mbsr25 412 10 Figure figure NN cord-024189-t7mbsr25 412 11 21B 21b NN cord-024189-t7mbsr25 412 12 -2 -2 CD cord-024189-t7mbsr25 412 13 ) ) -RRB- cord-024189-t7mbsr25 412 14 . . . cord-024189-t7mbsr25 413 1 Progressive progressive JJ cord-024189-t7mbsr25 413 2 sensory sensory JJ cord-024189-t7mbsr25 413 3 neuropathy neuropathy NN cord-024189-t7mbsr25 413 4 has have VBZ cord-024189-t7mbsr25 413 5 been be VBN cord-024189-t7mbsr25 413 6 described describe VBN cord-024189-t7mbsr25 413 7 less less RBR cord-024189-t7mbsr25 413 8 frequently frequently RB cord-024189-t7mbsr25 413 9 . . . cord-024189-t7mbsr25 414 1 Central central JJ cord-024189-t7mbsr25 414 2 nervous nervous JJ cord-024189-t7mbsr25 414 3 system system NN cord-024189-t7mbsr25 414 4 involvement involvement NN cord-024189-t7mbsr25 414 5 is be VBZ cord-024189-t7mbsr25 414 6 much much RB cord-024189-t7mbsr25 414 7 less less RBR cord-024189-t7mbsr25 414 8 common common JJ cord-024189-t7mbsr25 414 9 , , , cord-024189-t7mbsr25 414 10 but but CC cord-024189-t7mbsr25 414 11 has have VBZ cord-024189-t7mbsr25 414 12 been be VBN cord-024189-t7mbsr25 414 13 reported report VBN cord-024189-t7mbsr25 414 14 in in IN cord-024189-t7mbsr25 414 15 the the DT cord-024189-t7mbsr25 414 16 form form NN cord-024189-t7mbsr25 414 17 of of IN cord-024189-t7mbsr25 414 18 cerebrovascular cerebrovascular JJ cord-024189-t7mbsr25 414 19 accidents accident NNS cord-024189-t7mbsr25 414 20 . . . cord-024189-t7mbsr25 415 1 Polyarteritis Polyarteritis NNP cord-024189-t7mbsr25 415 2 nodosa nodosa RB cord-024189-t7mbsr25 415 3 can can MD cord-024189-t7mbsr25 415 4 have have VB cord-024189-t7mbsr25 415 5 multiple multiple JJ cord-024189-t7mbsr25 415 6 cutaneous cutaneous JJ cord-024189-t7mbsr25 415 7 manifestations manifestation NNS cord-024189-t7mbsr25 415 8 : : : cord-024189-t7mbsr25 415 9 livedo livedo NNP cord-024189-t7mbsr25 415 10 reticularis reticularis NNPS cord-024189-t7mbsr25 415 11 , , , cord-024189-t7mbsr25 415 12 nodules nodule NNS cord-024189-t7mbsr25 415 13 , , , cord-024189-t7mbsr25 415 14 ulcerations ulceration NNS cord-024189-t7mbsr25 415 15 ( ( -LRB- cord-024189-t7mbsr25 415 16 Figure figure NN cord-024189-t7mbsr25 415 17 21B 21b NN cord-024189-t7mbsr25 415 18 -3 -3 NNP cord-024189-t7mbsr25 415 19 ) ) -RRB- cord-024189-t7mbsr25 415 20 , , , cord-024189-t7mbsr25 415 21 and and CC cord-024189-t7mbsr25 415 22 frank frank JJ cord-024189-t7mbsr25 415 23 ischemia ischemia NN cord-024189-t7mbsr25 415 24 of of IN cord-024189-t7mbsr25 415 25 digits digit NNS cord-024189-t7mbsr25 415 26 ( ( -LRB- cord-024189-t7mbsr25 415 27 8) 8) NNP cord-024189-t7mbsr25 415 28 . . . cord-024189-t7mbsr25 416 1 A a DT cord-024189-t7mbsr25 416 2 small small JJ cord-024189-t7mbsr25 416 3 group group NN cord-024189-t7mbsr25 416 4 of of IN cord-024189-t7mbsr25 416 5 patients patient NNS cord-024189-t7mbsr25 416 6 have have VBP cord-024189-t7mbsr25 416 7 a a DT cord-024189-t7mbsr25 416 8 form form NN cord-024189-t7mbsr25 416 9 of of IN cord-024189-t7mbsr25 416 10 disease disease NN cord-024189-t7mbsr25 416 11 termed term VBD cord-024189-t7mbsr25 416 12 cutaneous cutaneous JJ cord-024189-t7mbsr25 416 13 PAN PAN NNP cord-024189-t7mbsr25 416 14 , , , cord-024189-t7mbsr25 416 15 a a DT cord-024189-t7mbsr25 416 16 variant variant NN cord-024189-t7mbsr25 416 17 limited limit VBN cord-024189-t7mbsr25 416 18 ostensibly ostensibly RB cord-024189-t7mbsr25 416 19 to to IN cord-024189-t7mbsr25 416 20 the the DT cord-024189-t7mbsr25 416 21 skin skin NN cord-024189-t7mbsr25 416 22 . . . cord-024189-t7mbsr25 417 1 These these DT cord-024189-t7mbsr25 417 2 patients patient NNS cord-024189-t7mbsr25 417 3 develop develop VBP cord-024189-t7mbsr25 417 4 nodules nodule NNS cord-024189-t7mbsr25 417 5 and and CC cord-024189-t7mbsr25 417 6 ulcerations ulceration NNS cord-024189-t7mbsr25 417 7 , , , cord-024189-t7mbsr25 417 8 primarily primarily RB cord-024189-t7mbsr25 417 9 of of IN cord-024189-t7mbsr25 417 10 the the DT cord-024189-t7mbsr25 417 11 lower low JJR cord-024189-t7mbsr25 417 12 legs leg NNS cord-024189-t7mbsr25 417 13 , , , cord-024189-t7mbsr25 417 14 which which WDT cord-024189-t7mbsr25 417 15 can can MD cord-024189-t7mbsr25 417 16 occur occur VB cord-024189-t7mbsr25 417 17 in in IN cord-024189-t7mbsr25 417 18 crops crop NNS cord-024189-t7mbsr25 417 19 and and CC cord-024189-t7mbsr25 417 20 can can MD cord-024189-t7mbsr25 417 21 be be VB cord-024189-t7mbsr25 417 22 very very RB cord-024189-t7mbsr25 417 23 painful painful JJ cord-024189-t7mbsr25 417 24 . . . cord-024189-t7mbsr25 418 1 However however RB cord-024189-t7mbsr25 418 2 , , , cord-024189-t7mbsr25 418 3 as as IN cord-024189-t7mbsr25 418 4 with with IN cord-024189-t7mbsr25 418 5 any any DT cord-024189-t7mbsr25 418 6 other other JJ cord-024189-t7mbsr25 418 7 vasculitis vasculitis NN cord-024189-t7mbsr25 418 8 , , , cord-024189-t7mbsr25 418 9 cutaneous cutaneous JJ cord-024189-t7mbsr25 418 10 manifestations manifestation NNS cord-024189-t7mbsr25 418 11 should should MD cord-024189-t7mbsr25 418 12 prompt prompt VB cord-024189-t7mbsr25 418 13 a a DT cord-024189-t7mbsr25 418 14 thorough thorough JJ cord-024189-t7mbsr25 418 15 evaluation evaluation NN cord-024189-t7mbsr25 418 16 for for IN cord-024189-t7mbsr25 418 17 evidence evidence NN cord-024189-t7mbsr25 418 18 of of IN cord-024189-t7mbsr25 418 19 systemic systemic JJ cord-024189-t7mbsr25 418 20 disease disease NN cord-024189-t7mbsr25 418 21 . . . cord-024189-t7mbsr25 419 1 As as IN cord-024189-t7mbsr25 419 2 with with IN cord-024189-t7mbsr25 419 3 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 419 4 's 's POS cord-024189-t7mbsr25 419 5 disease disease NN cord-024189-t7mbsr25 419 6 , , , cord-024189-t7mbsr25 419 7 the the DT cord-024189-t7mbsr25 419 8 other other JJ cord-024189-t7mbsr25 419 9 medium medium JJ cord-024189-t7mbsr25 419 10 vessel vessel NN cord-024189-t7mbsr25 419 11 vasculitis vasculitis NN cord-024189-t7mbsr25 419 12 described describe VBN cord-024189-t7mbsr25 419 13 in in IN cord-024189-t7mbsr25 419 14 this this DT cord-024189-t7mbsr25 419 15 text text NN cord-024189-t7mbsr25 419 16 , , , cord-024189-t7mbsr25 419 17 PAN PAN NNP cord-024189-t7mbsr25 419 18 can can MD cord-024189-t7mbsr25 419 19 also also RB cord-024189-t7mbsr25 419 20 involve involve VB cord-024189-t7mbsr25 419 21 the the DT cord-024189-t7mbsr25 419 22 coronary coronary JJ cord-024189-t7mbsr25 419 23 arteries artery NNS cord-024189-t7mbsr25 419 24 . . . cord-024189-t7mbsr25 420 1 Clinical clinical JJ cord-024189-t7mbsr25 420 2 proof proof NN cord-024189-t7mbsr25 420 3 of of IN cord-024189-t7mbsr25 420 4 coronary coronary JJ cord-024189-t7mbsr25 420 5 disease disease NN cord-024189-t7mbsr25 420 6 during during IN cord-024189-t7mbsr25 420 7 life life NN cord-024189-t7mbsr25 420 8 is be VBZ cord-024189-t7mbsr25 420 9 diffi diffi JJ cord-024189-t7mbsr25 420 10 cult cult NN cord-024189-t7mbsr25 420 11 . . . cord-024189-t7mbsr25 421 1 Myocardial myocardial JJ cord-024189-t7mbsr25 421 2 infarction infarction NN cord-024189-t7mbsr25 421 3 is be VBZ cord-024189-t7mbsr25 421 4 uncom uncom JJ cord-024189-t7mbsr25 421 5 - - HYPH cord-024189-t7mbsr25 421 6 mon mon NN cord-024189-t7mbsr25 421 7 , , , cord-024189-t7mbsr25 421 8 and and CC cord-024189-t7mbsr25 421 9 coronary coronary JJ cord-024189-t7mbsr25 421 10 involvement involvement NN cord-024189-t7mbsr25 421 11 is be VBZ cord-024189-t7mbsr25 421 12 usually usually RB cord-024189-t7mbsr25 421 13 only only RB cord-024189-t7mbsr25 421 14 seen see VBN cord-024189-t7mbsr25 421 15 at at IN cord-024189-t7mbsr25 421 16 autopsy autopsy NN cord-024189-t7mbsr25 421 17 . . . cord-024189-t7mbsr25 422 1 Contraction contraction NN cord-024189-t7mbsr25 422 2 band band NN cord-024189-t7mbsr25 422 3 necrosis necrosis NN cord-024189-t7mbsr25 422 4 , , , cord-024189-t7mbsr25 422 5 indicative indicative JJ cord-024189-t7mbsr25 422 6 of of IN cord-024189-t7mbsr25 422 7 segmental segmental JJ cord-024189-t7mbsr25 422 8 ischemia ischemia NN cord-024189-t7mbsr25 422 9 , , , cord-024189-t7mbsr25 422 10 is be VBZ cord-024189-t7mbsr25 422 11 a a DT cord-024189-t7mbsr25 422 12 common common JJ cord-024189-t7mbsr25 422 13 fi fi NN cord-024189-t7mbsr25 422 14 nding nding NN cord-024189-t7mbsr25 422 15 in in IN cord-024189-t7mbsr25 422 16 the the DT cord-024189-t7mbsr25 422 17 myocardium myocardium NN cord-024189-t7mbsr25 422 18 at at IN cord-024189-t7mbsr25 422 19 autopsy autopsy NN cord-024189-t7mbsr25 422 20 , , , cord-024189-t7mbsr25 422 21 attesting attest VBG cord-024189-t7mbsr25 422 22 to to IN cord-024189-t7mbsr25 422 23 the the DT cord-024189-t7mbsr25 422 24 presence presence NN cord-024189-t7mbsr25 422 25 of of IN cord-024189-t7mbsr25 422 26 vasculitis vasculitis NN cord-024189-t7mbsr25 422 27 below below IN cord-024189-t7mbsr25 422 28 the the DT cord-024189-t7mbsr25 422 29 resolution resolution NN cord-024189-t7mbsr25 422 30 of of IN cord-024189-t7mbsr25 422 31 conventional conventional JJ cord-024189-t7mbsr25 422 32 angiography angiography NN cord-024189-t7mbsr25 422 33 . . . cord-024189-t7mbsr25 423 1 PAN PAN NNP cord-024189-t7mbsr25 423 2 can can MD cord-024189-t7mbsr25 423 3 involve involve VB cord-024189-t7mbsr25 423 4 other other JJ cord-024189-t7mbsr25 423 5 organs organ NNS cord-024189-t7mbsr25 423 6 , , , cord-024189-t7mbsr25 423 7 such such JJ cord-024189-t7mbsr25 423 8 as as IN cord-024189-t7mbsr25 423 9 the the DT cord-024189-t7mbsr25 423 10 testicle testicle NN cord-024189-t7mbsr25 423 11 , , , cord-024189-t7mbsr25 423 12 ovary ovary NN cord-024189-t7mbsr25 423 13 , , , cord-024189-t7mbsr25 423 14 breast breast NN cord-024189-t7mbsr25 423 15 , , , cord-024189-t7mbsr25 423 16 and and CC cord-024189-t7mbsr25 423 17 eye eye NN cord-024189-t7mbsr25 423 18 . . . cord-024189-t7mbsr25 424 1 Polyarteritis Polyarteritis NNP cord-024189-t7mbsr25 424 2 nodosa nodosa RB cord-024189-t7mbsr25 424 3 is be VBZ cord-024189-t7mbsr25 424 4 characterized characterize VBN cord-024189-t7mbsr25 424 5 pathologically pathologically RB cord-024189-t7mbsr25 424 6 by by IN cord-024189-t7mbsr25 424 7 patchy patchy JJ cord-024189-t7mbsr25 424 8 , , , cord-024189-t7mbsr25 424 9 transmural transmural JJ cord-024189-t7mbsr25 424 10 infl infl NNP cord-024189-t7mbsr25 424 11 ammation ammation NNP cord-024189-t7mbsr25 424 12 in in IN cord-024189-t7mbsr25 424 13 medium medium NN cord-024189-t7mbsr25 424 14 - - : cord-024189-t7mbsr25 424 15 and and CC cord-024189-t7mbsr25 424 16 smallsized smallsize VBD cord-024189-t7mbsr25 424 17 muscular muscular JJ cord-024189-t7mbsr25 424 18 arteries artery NNS cord-024189-t7mbsr25 424 19 , , , cord-024189-t7mbsr25 424 20 sparing spare VBG cord-024189-t7mbsr25 424 21 large large JJ cord-024189-t7mbsr25 424 22 arteries artery NNS cord-024189-t7mbsr25 424 23 , , , cord-024189-t7mbsr25 424 24 capillaries capillary NNS cord-024189-t7mbsr25 424 25 , , , cord-024189-t7mbsr25 424 26 and and CC cord-024189-t7mbsr25 424 27 the the DT cord-024189-t7mbsr25 424 28 venous venous JJ cord-024189-t7mbsr25 424 29 system system NN cord-024189-t7mbsr25 424 30 . . . cord-024189-t7mbsr25 425 1 There there EX cord-024189-t7mbsr25 425 2 is be VBZ cord-024189-t7mbsr25 425 3 a a DT cord-024189-t7mbsr25 425 4 pleomorphic pleomorphic JJ cord-024189-t7mbsr25 425 5 cellular cellular JJ cord-024189-t7mbsr25 425 6 infi infi NNP cord-024189-t7mbsr25 425 7 ltrate ltrate NNP cord-024189-t7mbsr25 425 8 and and CC cord-024189-t7mbsr25 425 9 fi fi NNP cord-024189-t7mbsr25 425 10 brinoid brinoid FW cord-024189-t7mbsr25 425 11 necrosis necrosis NN cord-024189-t7mbsr25 425 12 in in IN cord-024189-t7mbsr25 425 13 the the DT cord-024189-t7mbsr25 425 14 vessel vessel NN cord-024189-t7mbsr25 425 15 , , , cord-024189-t7mbsr25 425 16 but but CC cord-024189-t7mbsr25 425 17 no no DT cord-024189-t7mbsr25 425 18 features feature NNS cord-024189-t7mbsr25 425 19 of of IN cord-024189-t7mbsr25 425 20 granulomatous granulomatous JJ cord-024189-t7mbsr25 425 21 infl infl NN cord-024189-t7mbsr25 425 22 ammation ammation NNP cord-024189-t7mbsr25 425 23 . . . cord-024189-t7mbsr25 426 1 Disruption disruption NN cord-024189-t7mbsr25 426 2 of of IN cord-024189-t7mbsr25 426 3 the the DT cord-024189-t7mbsr25 426 4 elastic elastic JJ cord-024189-t7mbsr25 426 5 laminae laminae NN cord-024189-t7mbsr25 426 6 of of IN cord-024189-t7mbsr25 426 7 the the DT cord-024189-t7mbsr25 426 8 vessel vessel NN cord-024189-t7mbsr25 426 9 wall wall NN cord-024189-t7mbsr25 426 10 can can MD cord-024189-t7mbsr25 426 11 lead lead VB cord-024189-t7mbsr25 426 12 to to IN cord-024189-t7mbsr25 426 13 aneurysmal aneurysmal JJ cord-024189-t7mbsr25 426 14 dilatation dilatation NN cord-024189-t7mbsr25 426 15 at at IN cord-024189-t7mbsr25 426 16 the the DT cord-024189-t7mbsr25 426 17 site site NN cord-024189-t7mbsr25 426 18 of of IN cord-024189-t7mbsr25 426 19 the the DT cord-024189-t7mbsr25 426 20 lesion lesion NN cord-024189-t7mbsr25 426 21 . . . cord-024189-t7mbsr25 427 1 PAN PAN NNP cord-024189-t7mbsr25 427 2 has have VBZ cord-024189-t7mbsr25 427 3 a a DT cord-024189-t7mbsr25 427 4 predilection predilection NN cord-024189-t7mbsr25 427 5 for for IN cord-024189-t7mbsr25 427 6 certain certain JJ cord-024189-t7mbsr25 427 7 organs organ NNS cord-024189-t7mbsr25 427 8 : : : cord-024189-t7mbsr25 427 9 arteries artery NNS cord-024189-t7mbsr25 427 10 to to IN cord-024189-t7mbsr25 427 11 the the DT cord-024189-t7mbsr25 427 12 kidney kidney NN cord-024189-t7mbsr25 427 13 are be VBP cord-024189-t7mbsr25 427 14 estimated estimate VBN cord-024189-t7mbsr25 427 15 to to TO cord-024189-t7mbsr25 427 16 be be VB cord-024189-t7mbsr25 427 17 involved involve VBN cord-024189-t7mbsr25 427 18 70 70 CD cord-024189-t7mbsr25 427 19 % % NN cord-024189-t7mbsr25 427 20 to to TO cord-024189-t7mbsr25 427 21 80 80 CD cord-024189-t7mbsr25 427 22 % % NN cord-024189-t7mbsr25 427 23 of of IN cord-024189-t7mbsr25 427 24 the the DT cord-024189-t7mbsr25 427 25 time time NN cord-024189-t7mbsr25 427 26 , , , cord-024189-t7mbsr25 427 27 the the DT cord-024189-t7mbsr25 427 28 GI GI NNP cord-024189-t7mbsr25 427 29 tract tract NN cord-024189-t7mbsr25 427 30 is be VBZ cord-024189-t7mbsr25 427 31 involved involve VBN cord-024189-t7mbsr25 427 32 in in IN cord-024189-t7mbsr25 427 33 50 50 CD cord-024189-t7mbsr25 427 34 % % NN cord-024189-t7mbsr25 427 35 of of IN cord-024189-t7mbsr25 427 36 cases case NNS cord-024189-t7mbsr25 427 37 , , , cord-024189-t7mbsr25 427 38 the the DT cord-024189-t7mbsr25 427 39 peripheral peripheral JJ cord-024189-t7mbsr25 427 40 nerves nerve NNS cord-024189-t7mbsr25 427 41 are be VBP cord-024189-t7mbsr25 427 42 involved involve VBN cord-024189-t7mbsr25 427 43 in in IN cord-024189-t7mbsr25 427 44 50 50 CD cord-024189-t7mbsr25 427 45 % % NN cord-024189-t7mbsr25 427 46 of of IN cord-024189-t7mbsr25 427 47 cases case NNS cord-024189-t7mbsr25 427 48 , , , cord-024189-t7mbsr25 427 49 and and CC cord-024189-t7mbsr25 427 50 the the DT cord-024189-t7mbsr25 427 51 central central JJ cord-024189-t7mbsr25 427 52 nervous nervous JJ cord-024189-t7mbsr25 427 53 system system NN cord-024189-t7mbsr25 427 54 is be VBZ cord-024189-t7mbsr25 427 55 involved involve VBN cord-024189-t7mbsr25 427 56 in in IN cord-024189-t7mbsr25 427 57 10 10 CD cord-024189-t7mbsr25 427 58 % % NN cord-024189-t7mbsr25 427 59 of of IN cord-024189-t7mbsr25 427 60 cases case NNS cord-024189-t7mbsr25 427 61 ( ( -LRB- cord-024189-t7mbsr25 427 62 9 9 CD cord-024189-t7mbsr25 427 63 ) ) -RRB- cord-024189-t7mbsr25 427 64 . . . cord-024189-t7mbsr25 428 1 Polyarteritis Polyarteritis NNP cord-024189-t7mbsr25 428 2 nodosa nodosa RB cord-024189-t7mbsr25 428 3 is be VBZ cord-024189-t7mbsr25 428 4 diagnosed diagnose VBN cord-024189-t7mbsr25 428 5 based base VBN cord-024189-t7mbsr25 428 6 on on IN cord-024189-t7mbsr25 428 7 characteristic characteristic JJ cord-024189-t7mbsr25 428 8 symptoms symptom NNS cord-024189-t7mbsr25 428 9 , , , cord-024189-t7mbsr25 428 10 physical physical JJ cord-024189-t7mbsr25 428 11 examination examination NN cord-024189-t7mbsr25 428 12 fi fi IN cord-024189-t7mbsr25 428 13 ndings nding NNS cord-024189-t7mbsr25 428 14 , , , cord-024189-t7mbsr25 428 15 and and CC cord-024189-t7mbsr25 428 16 compatible compatible JJ cord-024189-t7mbsr25 428 17 laboratory laboratory NN cord-024189-t7mbsr25 428 18 , , , cord-024189-t7mbsr25 428 19 angiographic angiographic JJ cord-024189-t7mbsr25 428 20 , , , cord-024189-t7mbsr25 428 21 and and CC cord-024189-t7mbsr25 428 22 pathologic pathologic JJ cord-024189-t7mbsr25 428 23 data datum NNS cord-024189-t7mbsr25 428 24 . . . cord-024189-t7mbsr25 429 1 Because because IN cord-024189-t7mbsr25 429 2 PAN PAN NNP cord-024189-t7mbsr25 429 3 is be VBZ cord-024189-t7mbsr25 429 4 a a DT cord-024189-t7mbsr25 429 5 rare rare JJ cord-024189-t7mbsr25 429 6 disease disease NN cord-024189-t7mbsr25 429 7 and and CC cord-024189-t7mbsr25 429 8 its -PRON- PRP$ cord-024189-t7mbsr25 429 9 treatment treatment NN cord-024189-t7mbsr25 429 10 can can MD cord-024189-t7mbsr25 429 11 result result VB cord-024189-t7mbsr25 429 12 in in IN cord-024189-t7mbsr25 429 13 serious serious JJ cord-024189-t7mbsr25 429 14 adverse adverse JJ cord-024189-t7mbsr25 429 15 events event NNS cord-024189-t7mbsr25 429 16 , , , cord-024189-t7mbsr25 429 17 the the DT cord-024189-t7mbsr25 429 18 diagnosis diagnosis NN cord-024189-t7mbsr25 429 19 should should MD cord-024189-t7mbsr25 429 20 be be VB cord-024189-t7mbsr25 429 21 supported support VBN cord-024189-t7mbsr25 429 22 with with IN cord-024189-t7mbsr25 429 23 either either DT cord-024189-t7mbsr25 429 24 abdominal abdominal JJ cord-024189-t7mbsr25 429 25 angiography angiography NN cord-024189-t7mbsr25 429 26 or or CC cord-024189-t7mbsr25 429 27 biopsy biopsy NN cord-024189-t7mbsr25 429 28 whenever whenever WRB cord-024189-t7mbsr25 429 29 possible possible JJ cord-024189-t7mbsr25 429 30 . . . cord-024189-t7mbsr25 430 1 PAN PAN NNP cord-024189-t7mbsr25 430 2 must must MD cord-024189-t7mbsr25 430 3 be be VB cord-024189-t7mbsr25 430 4 differentiated differentiate VBN cord-024189-t7mbsr25 430 5 from from IN cord-024189-t7mbsr25 430 6 other other JJ cord-024189-t7mbsr25 430 7 forms form NNS cord-024189-t7mbsr25 430 8 of of IN cord-024189-t7mbsr25 430 9 vasculitis vasculitis NN cord-024189-t7mbsr25 430 10 , , , cord-024189-t7mbsr25 430 11 such such JJ cord-024189-t7mbsr25 430 12 as as IN cord-024189-t7mbsr25 430 13 the the DT cord-024189-t7mbsr25 430 14 ANCA ANCA NNP cord-024189-t7mbsr25 430 15 - - HYPH cord-024189-t7mbsr25 430 16 associated associate VBN cord-024189-t7mbsr25 430 17 disorders disorder NNS cord-024189-t7mbsr25 430 18 , , , cord-024189-t7mbsr25 430 19 cryoglobulinemia cryoglobulinemia NN cord-024189-t7mbsr25 430 20 , , , cord-024189-t7mbsr25 430 21 and and CC cord-024189-t7mbsr25 430 22 Buerger Buerger NNP cord-024189-t7mbsr25 430 23 's 's POS cord-024189-t7mbsr25 430 24 disease disease NN cord-024189-t7mbsr25 430 25 . . . cord-024189-t7mbsr25 431 1 Common common JJ cord-024189-t7mbsr25 431 2 vasculitis vasculitis NN cord-024189-t7mbsr25 431 3 mimics mimic VBZ cord-024189-t7mbsr25 431 4 , , , cord-024189-t7mbsr25 431 5 such such JJ cord-024189-t7mbsr25 431 6 as as IN cord-024189-t7mbsr25 431 7 viral viral JJ cord-024189-t7mbsr25 431 8 hepatitis hepatitis NN cord-024189-t7mbsr25 431 9 , , , cord-024189-t7mbsr25 431 10 bacterial bacterial JJ cord-024189-t7mbsr25 431 11 endocarditis endocarditis NN cord-024189-t7mbsr25 431 12 , , , cord-024189-t7mbsr25 431 13 or or CC cord-024189-t7mbsr25 431 14 other other JJ cord-024189-t7mbsr25 431 15 embolic embolic JJ cord-024189-t7mbsr25 431 16 diseases disease NNS cord-024189-t7mbsr25 431 17 , , , cord-024189-t7mbsr25 431 18 should should MD cord-024189-t7mbsr25 431 19 be be VB cord-024189-t7mbsr25 431 20 excluded exclude VBN cord-024189-t7mbsr25 431 21 . . . cord-024189-t7mbsr25 432 1 Undiagnosed undiagnosed JJ cord-024189-t7mbsr25 432 2 connective connective JJ cord-024189-t7mbsr25 432 3 tissue tissue NN cord-024189-t7mbsr25 432 4 diseases disease NNS cord-024189-t7mbsr25 432 5 , , , cord-024189-t7mbsr25 432 6 such such JJ cord-024189-t7mbsr25 432 7 as as IN cord-024189-t7mbsr25 432 8 systemic systemic JJ cord-024189-t7mbsr25 432 9 lupus lupus NN cord-024189-t7mbsr25 432 10 erythematosus erythematosus NN cord-024189-t7mbsr25 432 11 , , , cord-024189-t7mbsr25 432 12 rheumatoid rheumatoid NN cord-024189-t7mbsr25 432 13 arthritis arthritis NN cord-024189-t7mbsr25 432 14 , , , cord-024189-t7mbsr25 432 15 or or CC cord-024189-t7mbsr25 432 16 systemic systemic JJ cord-024189-t7mbsr25 432 17 sclerosis sclerosis NN cord-024189-t7mbsr25 432 18 , , , cord-024189-t7mbsr25 432 19 must must MD cord-024189-t7mbsr25 432 20 be be VB cord-024189-t7mbsr25 432 21 ruled rule VBN cord-024189-t7mbsr25 432 22 out out RP cord-024189-t7mbsr25 432 23 , , , cord-024189-t7mbsr25 432 24 as as IN cord-024189-t7mbsr25 432 25 such such JJ cord-024189-t7mbsr25 432 26 diseases disease NNS cord-024189-t7mbsr25 432 27 can can MD cord-024189-t7mbsr25 432 28 be be VB cord-024189-t7mbsr25 432 29 associated associate VBN cord-024189-t7mbsr25 432 30 with with IN cord-024189-t7mbsr25 432 31 systemic systemic JJ cord-024189-t7mbsr25 432 32 vasculitis vasculitis NN cord-024189-t7mbsr25 432 33 or or CC cord-024189-t7mbsr25 432 34 widespread widespread JJ cord-024189-t7mbsr25 432 35 vascular vascular JJ cord-024189-t7mbsr25 432 36 dysfunction dysfunction NN cord-024189-t7mbsr25 432 37 that that WDT cord-024189-t7mbsr25 432 38 involves involve VBZ cord-024189-t7mbsr25 432 39 multiple multiple JJ cord-024189-t7mbsr25 432 40 organs organ NNS cord-024189-t7mbsr25 432 41 . . . cord-024189-t7mbsr25 433 1 Atrophie Atrophie NNP cord-024189-t7mbsr25 433 2 blanche blanche NNP cord-024189-t7mbsr25 433 3 , , , cord-024189-t7mbsr25 433 4 a a DT cord-024189-t7mbsr25 433 5 thrombotic thrombotic JJ cord-024189-t7mbsr25 433 6 disorder disorder NN cord-024189-t7mbsr25 433 7 that that WDT cord-024189-t7mbsr25 433 8 may may MD cord-024189-t7mbsr25 433 9 lead lead VB cord-024189-t7mbsr25 433 10 to to IN cord-024189-t7mbsr25 433 11 lower low JJR cord-024189-t7mbsr25 433 12 extremity extremity NN cord-024189-t7mbsr25 433 13 ulcerations ulceration NNS cord-024189-t7mbsr25 433 14 , , , cord-024189-t7mbsr25 433 15 must must MD cord-024189-t7mbsr25 433 16 be be VB cord-024189-t7mbsr25 433 17 differentiated differentiate VBN cord-024189-t7mbsr25 433 18 from from IN cord-024189-t7mbsr25 433 19 PAN PAN NNP cord-024189-t7mbsr25 433 20 by by IN cord-024189-t7mbsr25 433 21 skin skin NN cord-024189-t7mbsr25 433 22 biopsy biopsy NN cord-024189-t7mbsr25 433 23 . . . cord-024189-t7mbsr25 434 1 The the DT cord-024189-t7mbsr25 434 2 American American NNP cord-024189-t7mbsr25 434 3 College College NNP cord-024189-t7mbsr25 434 4 of of IN cord-024189-t7mbsr25 434 5 Rheumatology Rheumatology NNP cord-024189-t7mbsr25 434 6 criteria criterion NNS cord-024189-t7mbsr25 434 7 for for IN cord-024189-t7mbsr25 434 8 the the DT cord-024189-t7mbsr25 434 9 classifi classifi NNP cord-024189-t7mbsr25 434 10 cation cation NN cord-024189-t7mbsr25 434 11 of of IN cord-024189-t7mbsr25 434 12 PAN PAN NNP cord-024189-t7mbsr25 434 13 are be VBP cord-024189-t7mbsr25 434 14 listed list VBN cord-024189-t7mbsr25 434 15 in in IN cord-024189-t7mbsr25 434 16 Table Table NNP cord-024189-t7mbsr25 434 17 21B 21b NN cord-024189-t7mbsr25 434 18 -2 -2 NNP cord-024189-t7mbsr25 434 19 ( ( -LRB- cord-024189-t7mbsr25 434 20 5 5 CD cord-024189-t7mbsr25 434 21 ) ) -RRB- cord-024189-t7mbsr25 434 22 . . . cord-024189-t7mbsr25 435 1 The the DT cord-024189-t7mbsr25 435 2 criteria criterion NNS cord-024189-t7mbsr25 435 3 were be VBD cord-024189-t7mbsr25 435 4 developed develop VBN cord-024189-t7mbsr25 435 5 through through IN cord-024189-t7mbsr25 435 6 the the DT cord-024189-t7mbsr25 435 7 selection selection NN cord-024189-t7mbsr25 435 8 of of IN cord-024189-t7mbsr25 435 9 clinical clinical JJ cord-024189-t7mbsr25 435 10 fi fi NN cord-024189-t7mbsr25 435 11 ndings nding NNS cord-024189-t7mbsr25 435 12 that that WDT cord-024189-t7mbsr25 435 13 identify identify VBP cord-024189-t7mbsr25 435 14 PAN PAN NNP cord-024189-t7mbsr25 435 15 and and CC cord-024189-t7mbsr25 435 16 distinguish distinguish VB cord-024189-t7mbsr25 435 17 it -PRON- PRP cord-024189-t7mbsr25 435 18 from from IN cord-024189-t7mbsr25 435 19 other other JJ cord-024189-t7mbsr25 435 20 forms form NNS cord-024189-t7mbsr25 435 21 of of IN cord-024189-t7mbsr25 435 22 vasculitis vasculitis NN cord-024189-t7mbsr25 435 23 . . . cord-024189-t7mbsr25 436 1 Although although IN cord-024189-t7mbsr25 436 2 the the DT cord-024189-t7mbsr25 436 3 criteria criterion NNS cord-024189-t7mbsr25 436 4 are be VBP cord-024189-t7mbsr25 436 5 useful useful JJ cord-024189-t7mbsr25 436 6 for for IN cord-024189-t7mbsr25 436 7 classifying classify VBG cord-024189-t7mbsr25 436 8 patients patient NNS cord-024189-t7mbsr25 436 9 in in IN cord-024189-t7mbsr25 436 10 clinical clinical JJ cord-024189-t7mbsr25 436 11 studies study NNS cord-024189-t7mbsr25 436 12 , , , cord-024189-t7mbsr25 436 13 they -PRON- PRP cord-024189-t7mbsr25 436 14 were be VBD cord-024189-t7mbsr25 436 15 not not RB cord-024189-t7mbsr25 436 16 intended intend VBN cord-024189-t7mbsr25 436 17 for for IN cord-024189-t7mbsr25 436 18 use use NN cord-024189-t7mbsr25 436 19 in in IN cord-024189-t7mbsr25 436 20 diagnosing diagnose VBG cord-024189-t7mbsr25 436 21 individual individual JJ cord-024189-t7mbsr25 436 22 patients patient NNS cord-024189-t7mbsr25 436 23 ( ( -LRB- cord-024189-t7mbsr25 436 24 10 10 CD cord-024189-t7mbsr25 436 25 ) ) -RRB- cord-024189-t7mbsr25 436 26 . . . cord-024189-t7mbsr25 437 1 Routine routine JJ cord-024189-t7mbsr25 437 2 laboratory laboratory NN cord-024189-t7mbsr25 437 3 studies study NNS cord-024189-t7mbsr25 437 4 are be VBP cord-024189-t7mbsr25 437 5 often often RB cord-024189-t7mbsr25 437 6 abnormal abnormal JJ cord-024189-t7mbsr25 437 7 but but CC cord-024189-t7mbsr25 437 8 nonspecifi nonspecifi NNP cord-024189-t7mbsr25 437 9 c c NN cord-024189-t7mbsr25 437 10 , , , cord-024189-t7mbsr25 437 11 such such JJ cord-024189-t7mbsr25 437 12 as as IN cord-024189-t7mbsr25 437 13 elevated elevated JJ cord-024189-t7mbsr25 437 14 infl infl NN cord-024189-t7mbsr25 437 15 ammatory ammatory NN cord-024189-t7mbsr25 437 16 markers marker NNS cord-024189-t7mbsr25 437 17 ( ( -LRB- cord-024189-t7mbsr25 437 18 erythrocyte erythrocyte NN cord-024189-t7mbsr25 437 19 sedimentation sedimentation NN cord-024189-t7mbsr25 437 20 rate rate NN cord-024189-t7mbsr25 437 21 or or CC cord-024189-t7mbsr25 437 22 C c NN cord-024189-t7mbsr25 437 23 - - HYPH cord-024189-t7mbsr25 437 24 reactive reactive JJ cord-024189-t7mbsr25 437 25 protein protein NN cord-024189-t7mbsr25 437 26 ) ) -RRB- cord-024189-t7mbsr25 437 27 , , , cord-024189-t7mbsr25 437 28 anemia anemia NN cord-024189-t7mbsr25 437 29 , , , cord-024189-t7mbsr25 437 30 and and CC cord-024189-t7mbsr25 437 31 thrombocytosis thrombocytosis NNP cord-024189-t7mbsr25 437 32 . . . cord-024189-t7mbsr25 438 1 The the DT cord-024189-t7mbsr25 438 2 patient patient NN cord-024189-t7mbsr25 438 3 may may MD cord-024189-t7mbsr25 438 4 have have VB cord-024189-t7mbsr25 438 5 mild mild JJ cord-024189-t7mbsr25 438 6 renal renal JJ cord-024189-t7mbsr25 438 7 insuffi insuffi NN cord-024189-t7mbsr25 438 8 ciency ciency NN cord-024189-t7mbsr25 438 9 , , , cord-024189-t7mbsr25 438 10 with with IN cord-024189-t7mbsr25 438 11 an an DT cord-024189-t7mbsr25 438 12 elevated elevated JJ cord-024189-t7mbsr25 438 13 blood blood NN cord-024189-t7mbsr25 438 14 urea urea NN cord-024189-t7mbsr25 438 15 nitrogen nitrogen NN cord-024189-t7mbsr25 438 16 and and CC cord-024189-t7mbsr25 438 17 creatinine creatinine NN cord-024189-t7mbsr25 438 18 . . . cord-024189-t7mbsr25 439 1 Non non JJ cord-024189-t7mbsr25 439 2 - - JJ cord-024189-t7mbsr25 439 3 nephrotic nephrotic JJ cord-024189-t7mbsr25 439 4 range range NN cord-024189-t7mbsr25 439 5 proteinuria proteinuria NN cord-024189-t7mbsr25 439 6 and and CC cord-024189-t7mbsr25 439 7 mild mild JJ cord-024189-t7mbsr25 439 8 hematuria hematuria NN cord-024189-t7mbsr25 439 9 are be VBP cord-024189-t7mbsr25 439 10 also also RB cord-024189-t7mbsr25 439 11 seen see VBN cord-024189-t7mbsr25 439 12 , , , cord-024189-t7mbsr25 439 13 but but CC cord-024189-t7mbsr25 439 14 active active JJ cord-024189-t7mbsr25 439 15 urine urine NN cord-024189-t7mbsr25 439 16 sediments sediment NNS cord-024189-t7mbsr25 439 17 are be VBP cord-024189-t7mbsr25 439 18 not not RB cord-024189-t7mbsr25 439 19 a a DT cord-024189-t7mbsr25 439 20 feature feature NN cord-024189-t7mbsr25 439 21 of of IN cord-024189-t7mbsr25 439 22 PAN PAN NNP cord-024189-t7mbsr25 439 23 . . . cord-024189-t7mbsr25 440 1 As as IN cord-024189-t7mbsr25 440 2 not not RB cord-024189-t7mbsr25 440 3 , , , cord-024189-t7mbsr25 440 4 PAN PAN NNP cord-024189-t7mbsr25 440 5 is be VBZ cord-024189-t7mbsr25 440 6 not not RB cord-024189-t7mbsr25 440 7 associated associate VBN cord-024189-t7mbsr25 440 8 with with IN cord-024189-t7mbsr25 440 9 ANCA ANCA NNP cord-024189-t7mbsr25 440 10 . . . cord-024189-t7mbsr25 441 1 Indeed indeed RB cord-024189-t7mbsr25 441 2 , , , cord-024189-t7mbsr25 441 3 there there EX cord-024189-t7mbsr25 441 4 is be VBZ cord-024189-t7mbsr25 441 5 no no DT cord-024189-t7mbsr25 441 6 characteristic characteristic JJ cord-024189-t7mbsr25 441 7 autoantibody autoantibody NN cord-024189-t7mbsr25 441 8 for for IN cord-024189-t7mbsr25 441 9 PAN PAN NNP cord-024189-t7mbsr25 441 10 - - : cord-024189-t7mbsr25 441 11 a a DT cord-024189-t7mbsr25 441 12 fact fact NN cord-024189-t7mbsr25 441 13 that that WDT cord-024189-t7mbsr25 441 14 creates create VBZ cord-024189-t7mbsr25 441 15 one one CD cord-024189-t7mbsr25 441 16 of of IN cord-024189-t7mbsr25 441 17 the the DT cord-024189-t7mbsr25 441 18 diagnostic diagnostic JJ cord-024189-t7mbsr25 441 19 challenges challenge NNS cord-024189-t7mbsr25 441 20 in in IN cord-024189-t7mbsr25 441 21 this this DT cord-024189-t7mbsr25 441 22 disease disease NN cord-024189-t7mbsr25 441 23 . . . cord-024189-t7mbsr25 442 1 Electromyography electromyography NN cord-024189-t7mbsr25 442 2 / / SYM cord-024189-t7mbsr25 442 3 nerve nerve NN cord-024189-t7mbsr25 442 4 conduction conduction NN cord-024189-t7mbsr25 442 5 velocity velocity NN cord-024189-t7mbsr25 443 1 ( ( -LRB- cord-024189-t7mbsr25 443 2 EMG EMG NNP cord-024189-t7mbsr25 443 3 / / SYM cord-024189-t7mbsr25 443 4 NCV NCV NNP cord-024189-t7mbsr25 443 5 ) ) -RRB- cord-024189-t7mbsr25 443 6 studies study NNS cord-024189-t7mbsr25 443 7 may may MD cord-024189-t7mbsr25 443 8 be be VB cord-024189-t7mbsr25 443 9 very very RB cord-024189-t7mbsr25 443 10 useful useful JJ cord-024189-t7mbsr25 443 11 in in IN cord-024189-t7mbsr25 443 12 confi confi NN cord-024189-t7mbsr25 443 13 rming rming NN cord-024189-t7mbsr25 443 14 patterns pattern NNS cord-024189-t7mbsr25 443 15 of of IN cord-024189-t7mbsr25 443 16 nerve nerve NN cord-024189-t7mbsr25 443 17 dysfunction dysfunction NN cord-024189-t7mbsr25 443 18 consistent consistent JJ cord-024189-t7mbsr25 443 19 with with IN cord-024189-t7mbsr25 443 20 mononeuritis mononeuritis NNP cord-024189-t7mbsr25 443 21 multiplex multiplex NN cord-024189-t7mbsr25 443 22 ; ; : cord-024189-t7mbsr25 443 23 namely namely RB cord-024189-t7mbsr25 443 24 , , , cord-024189-t7mbsr25 443 25 a a DT cord-024189-t7mbsr25 443 26 distal distal JJ cord-024189-t7mbsr25 443 27 , , , cord-024189-t7mbsr25 443 28 asymmetric asymmetric JJ cord-024189-t7mbsr25 443 29 , , , cord-024189-t7mbsr25 443 30 axonal axonal JJ cord-024189-t7mbsr25 443 31 neuropathy neuropathy NN cord-024189-t7mbsr25 443 32 involving involve VBG cord-024189-t7mbsr25 443 33 both both CC cord-024189-t7mbsr25 443 34 motor motor NN cord-024189-t7mbsr25 443 35 and and CC cord-024189-t7mbsr25 443 36 sensory sensory JJ cord-024189-t7mbsr25 443 37 nerves nerve NNS cord-024189-t7mbsr25 443 38 . . . cord-024189-t7mbsr25 444 1 Imaging imaging NN cord-024189-t7mbsr25 444 2 in in IN cord-024189-t7mbsr25 444 3 a a DT cord-024189-t7mbsr25 444 4 patient patient NN cord-024189-t7mbsr25 444 5 with with IN cord-024189-t7mbsr25 444 6 suspected suspect VBN cord-024189-t7mbsr25 444 7 PAN PAN NNP cord-024189-t7mbsr25 444 8 should should MD cord-024189-t7mbsr25 444 9 be be VB cord-024189-t7mbsr25 444 10 guided guide VBN cord-024189-t7mbsr25 444 11 by by IN cord-024189-t7mbsr25 444 12 symptoms symptom NNS cord-024189-t7mbsr25 444 13 . . . cord-024189-t7mbsr25 445 1 In in IN cord-024189-t7mbsr25 445 2 patients patient NNS cord-024189-t7mbsr25 445 3 with with IN cord-024189-t7mbsr25 445 4 abdominal abdominal JJ cord-024189-t7mbsr25 445 5 pain pain NN cord-024189-t7mbsr25 445 6 , , , cord-024189-t7mbsr25 445 7 abdominal abdominal JJ cord-024189-t7mbsr25 445 8 arteriography arteriography NN cord-024189-t7mbsr25 445 9 often often RB cord-024189-t7mbsr25 445 10 reveals reveal VBZ cord-024189-t7mbsr25 445 11 characteristic characteristic JJ cord-024189-t7mbsr25 445 12 strictures stricture NNS cord-024189-t7mbsr25 445 13 and and CC cord-024189-t7mbsr25 445 14 aneurysms aneurysm NNS cord-024189-t7mbsr25 445 15 ( ( -LRB- cord-024189-t7mbsr25 445 16 beading beading NN cord-024189-t7mbsr25 445 17 ) ) -RRB- cord-024189-t7mbsr25 445 18 of of IN cord-024189-t7mbsr25 445 19 the the DT cord-024189-t7mbsr25 445 20 mesenteric mesenteric JJ cord-024189-t7mbsr25 445 21 vessels vessel NNS cord-024189-t7mbsr25 445 22 [ [ -LRB- cord-024189-t7mbsr25 445 23 see see VB cord-024189-t7mbsr25 445 24 Figure figure NN cord-024189-t7mbsr25 445 25 21B 21b NN cord-024189-t7mbsr25 445 26 -1(B -1(b ADD cord-024189-t7mbsr25 445 27 ) ) -RRB- cord-024189-t7mbsr25 445 28 ] ] -RRB- cord-024189-t7mbsr25 445 29 . . . cord-024189-t7mbsr25 446 1 Similar similar JJ cord-024189-t7mbsr25 446 2 fi fi IN cord-024189-t7mbsr25 446 3 ndings nding NNS cord-024189-t7mbsr25 446 4 can can MD cord-024189-t7mbsr25 446 5 be be VB cord-024189-t7mbsr25 446 6 seen see VBN cord-024189-t7mbsr25 446 7 in in IN cord-024189-t7mbsr25 446 8 the the DT cord-024189-t7mbsr25 446 9 renal renal JJ cord-024189-t7mbsr25 446 10 vasculature vasculature NN cord-024189-t7mbsr25 446 11 . . . cord-024189-t7mbsr25 447 1 As as IN cord-024189-t7mbsr25 447 2 with with IN cord-024189-t7mbsr25 447 3 imaging imaging NN cord-024189-t7mbsr25 447 4 , , , cord-024189-t7mbsr25 447 5 biopsy biopsy NN cord-024189-t7mbsr25 447 6 should should MD cord-024189-t7mbsr25 447 7 be be VB cord-024189-t7mbsr25 447 8 guided guide VBN cord-024189-t7mbsr25 447 9 by by IN cord-024189-t7mbsr25 447 10 organ organ NN cord-024189-t7mbsr25 447 11 involvement involvement NN cord-024189-t7mbsr25 447 12 . . . cord-024189-t7mbsr25 448 1 Blind blind JJ cord-024189-t7mbsr25 448 2 biopsy biopsy NN cord-024189-t7mbsr25 448 3 of of IN cord-024189-t7mbsr25 448 4 an an DT cord-024189-t7mbsr25 448 5 asymptomatic asymptomatic JJ cord-024189-t7mbsr25 448 6 organ organ NN cord-024189-t7mbsr25 448 7 , , , cord-024189-t7mbsr25 448 8 such such JJ cord-024189-t7mbsr25 448 9 as as IN cord-024189-t7mbsr25 448 10 muscle muscle NN cord-024189-t7mbsr25 448 11 or or CC cord-024189-t7mbsr25 448 12 testicle testicle NN cord-024189-t7mbsr25 448 13 , , , cord-024189-t7mbsr25 448 14 is be VBZ cord-024189-t7mbsr25 448 15 not not RB cord-024189-t7mbsr25 448 16 recommended recommend VBN cord-024189-t7mbsr25 448 17 . . . cord-024189-t7mbsr25 449 1 Skin skin NN cord-024189-t7mbsr25 449 2 biopsy biopsy NN cord-024189-t7mbsr25 449 3 is be VBZ cord-024189-t7mbsr25 449 4 often often RB cord-024189-t7mbsr25 449 5 the the DT cord-024189-t7mbsr25 449 6 easiest easy JJS cord-024189-t7mbsr25 449 7 way way NN cord-024189-t7mbsr25 449 8 to to IN cord-024189-t7mbsr25 449 9 confi confi NNP cord-024189-t7mbsr25 449 10 rm rm NNP cord-024189-t7mbsr25 450 1 this this DT cord-024189-t7mbsr25 450 2 diagnosis diagnosis NN cord-024189-t7mbsr25 450 3 , , , cord-024189-t7mbsr25 450 4 with with IN cord-024189-t7mbsr25 450 5 a a DT cord-024189-t7mbsr25 450 6 biopsy biopsy NN cord-024189-t7mbsr25 450 7 from from IN cord-024189-t7mbsr25 450 8 the the DT cord-024189-t7mbsr25 450 9 center center NN cord-024189-t7mbsr25 450 10 of of IN cord-024189-t7mbsr25 450 11 a a DT cord-024189-t7mbsr25 450 12 nodule nodule NN cord-024189-t7mbsr25 450 13 or or CC cord-024189-t7mbsr25 450 14 the the DT cord-024189-t7mbsr25 450 15 edge edge NN cord-024189-t7mbsr25 450 16 of of IN cord-024189-t7mbsr25 450 17 a a DT cord-024189-t7mbsr25 450 18 vasculitic vasculitic JJ cord-024189-t7mbsr25 450 19 ulcer ulcer NN cord-024189-t7mbsr25 450 20 . . . cord-024189-t7mbsr25 451 1 Routine routine JJ cord-024189-t7mbsr25 451 2 punch punch NN cord-024189-t7mbsr25 451 3 biopsy biopsy NN cord-024189-t7mbsr25 451 4 of of IN cord-024189-t7mbsr25 451 5 involved involved JJ cord-024189-t7mbsr25 451 6 skin skin NN cord-024189-t7mbsr25 451 7 reveals reveal VBZ cord-024189-t7mbsr25 451 8 leukocytoclastic leukocytoclastic JJ cord-024189-t7mbsr25 451 9 vasculitis vasculitis NN cord-024189-t7mbsr25 451 10 and and CC cord-024189-t7mbsr25 451 11 fi fi NN cord-024189-t7mbsr25 451 12 brinoid brinoid FW cord-024189-t7mbsr25 451 13 necrosis necrosis NN cord-024189-t7mbsr25 451 14 within within IN cord-024189-t7mbsr25 451 15 the the DT cord-024189-t7mbsr25 451 16 blood blood NN cord-024189-t7mbsr25 451 17 vessel vessel NN cord-024189-t7mbsr25 451 18 wall wall NN cord-024189-t7mbsr25 451 19 . . . cord-024189-t7mbsr25 452 1 Because because IN cord-024189-t7mbsr25 452 2 punch punch NN cord-024189-t7mbsr25 452 3 biopsy biopsy NN cord-024189-t7mbsr25 452 4 samples sample NNS cord-024189-t7mbsr25 452 5 include include VBP cord-024189-t7mbsr25 452 6 only only RB cord-024189-t7mbsr25 452 7 epidermis epidermis NN cord-024189-t7mbsr25 452 8 and and CC cord-024189-t7mbsr25 452 9 superfi superfi NNS cord-024189-t7mbsr25 452 10 cial cial JJ cord-024189-t7mbsr25 452 11 dermis dermis NN cord-024189-t7mbsr25 452 12 , , , cord-024189-t7mbsr25 452 13 they -PRON- PRP cord-024189-t7mbsr25 452 14 do do VBP cord-024189-t7mbsr25 452 15 not not RB cord-024189-t7mbsr25 452 16 capture capture VB cord-024189-t7mbsr25 452 17 medium medium NN cord-024189-t7mbsr25 452 18 - - HYPH cord-024189-t7mbsr25 452 19 sized sized JJ cord-024189-t7mbsr25 452 20 , , , cord-024189-t7mbsr25 452 21 muscular muscular JJ cord-024189-t7mbsr25 452 22 - - HYPH cord-024189-t7mbsr25 452 23 walled walled JJ cord-024189-t7mbsr25 452 24 arteries artery NNS cord-024189-t7mbsr25 452 25 whose whose WP$ cord-024189-t7mbsr25 452 26 infl infl NN cord-024189-t7mbsr25 452 27 ammation ammation NNP cord-024189-t7mbsr25 452 28 is be VBZ cord-024189-t7mbsr25 452 29 characteristic characteristic JJ cord-024189-t7mbsr25 452 30 of of IN cord-024189-t7mbsr25 452 31 PAN PAN NNP cord-024189-t7mbsr25 452 32 . . . cord-024189-t7mbsr25 453 1 When when WRB cord-024189-t7mbsr25 453 2 PAN PAN NNP cord-024189-t7mbsr25 453 3 is be VBZ cord-024189-t7mbsr25 453 4 suspected suspect VBN cord-024189-t7mbsr25 453 5 and and CC cord-024189-t7mbsr25 453 6 skin skin NN cord-024189-t7mbsr25 453 7 biopsy biopsy NN cord-024189-t7mbsr25 453 8 is be VBZ cord-024189-t7mbsr25 453 9 indicated indicate VBN cord-024189-t7mbsr25 453 10 , , , cord-024189-t7mbsr25 453 11 a a DT cord-024189-t7mbsr25 453 12 full full JJ cord-024189-t7mbsr25 453 13 thickness thickness NN cord-024189-t7mbsr25 453 14 skin skin NN cord-024189-t7mbsr25 453 15 biopsy biopsy NN cord-024189-t7mbsr25 453 16 that that WDT cord-024189-t7mbsr25 453 17 includes include VBZ cord-024189-t7mbsr25 453 18 some some DT cord-024189-t7mbsr25 453 19 subcutaneous subcutaneous JJ cord-024189-t7mbsr25 453 20 fat fat NN cord-024189-t7mbsr25 453 21 should should MD cord-024189-t7mbsr25 453 22 be be VB cord-024189-t7mbsr25 453 23 performed perform VBN cord-024189-t7mbsr25 453 24 ( ( -LRB- cord-024189-t7mbsr25 453 25 arteries artery NNS cord-024189-t7mbsr25 453 26 within within IN cord-024189-t7mbsr25 453 27 the the DT cord-024189-t7mbsr25 453 28 fat fat JJ cord-024189-t7mbsr25 453 29 lobules lobule NNS cord-024189-t7mbsr25 453 30 of of IN cord-024189-t7mbsr25 453 31 subcutaneous subcutaneous JJ cord-024189-t7mbsr25 453 32 tissue tissue NN cord-024189-t7mbsr25 453 33 are be VBP cord-024189-t7mbsr25 453 34 often often RB cord-024189-t7mbsr25 453 35 involved involve VBN cord-024189-t7mbsr25 453 36 . . . cord-024189-t7mbsr25 453 37 ) ) -RRB- cord-024189-t7mbsr25 454 1 Another another DT cord-024189-t7mbsr25 454 2 option option NN cord-024189-t7mbsr25 454 3 for for IN cord-024189-t7mbsr25 454 4 confi confi NNP cord-024189-t7mbsr25 454 5 rming rme VBG cord-024189-t7mbsr25 454 6 the the DT cord-024189-t7mbsr25 454 7 diagnosis diagnosis NN cord-024189-t7mbsr25 454 8 of of IN cord-024189-t7mbsr25 454 9 PAN PAN NNP cord-024189-t7mbsr25 454 10 is be VBZ cord-024189-t7mbsr25 454 11 a a DT cord-024189-t7mbsr25 454 12 peripheral peripheral JJ cord-024189-t7mbsr25 454 13 nerve nerve NN cord-024189-t7mbsr25 454 14 biopsy biopsy NN cord-024189-t7mbsr25 454 15 . . . cord-024189-t7mbsr25 455 1 The the DT cord-024189-t7mbsr25 455 2 sural sural JJ cord-024189-t7mbsr25 455 3 nerve nerve NN cord-024189-t7mbsr25 455 4 is be VBZ cord-024189-t7mbsr25 455 5 biopsied biopsie VBN cord-024189-t7mbsr25 455 6 most most RBS cord-024189-t7mbsr25 455 7 often often RB cord-024189-t7mbsr25 455 8 because because IN cord-024189-t7mbsr25 455 9 it -PRON- PRP cord-024189-t7mbsr25 455 10 does do VBZ cord-024189-t7mbsr25 455 11 not not RB cord-024189-t7mbsr25 455 12 mediate mediate VB cord-024189-t7mbsr25 455 13 motor motor NN cord-024189-t7mbsr25 455 14 function function NN cord-024189-t7mbsr25 455 15 . . . cord-024189-t7mbsr25 456 1 Whenever whenever WRB cord-024189-t7mbsr25 456 2 the the DT cord-024189-t7mbsr25 456 3 sural sural JJ cord-024189-t7mbsr25 456 4 nerve nerve NN cord-024189-t7mbsr25 456 5 is be VBZ cord-024189-t7mbsr25 456 6 biopsied biopsie VBN cord-024189-t7mbsr25 456 7 , , , cord-024189-t7mbsr25 456 8 a a DT cord-024189-t7mbsr25 456 9 muscle muscle NN cord-024189-t7mbsr25 456 10 biopsy biopsy NN cord-024189-t7mbsr25 456 11 ( ( -LRB- cord-024189-t7mbsr25 456 12 of of IN cord-024189-t7mbsr25 456 13 the the DT cord-024189-t7mbsr25 456 14 gastrocnemius gastrocnemius NN cord-024189-t7mbsr25 456 15 ) ) -RRB- cord-024189-t7mbsr25 456 16 should should MD cord-024189-t7mbsr25 456 17 be be VB cord-024189-t7mbsr25 456 18 performed perform VBN cord-024189-t7mbsr25 456 19 simultaneously simultaneously RB cord-024189-t7mbsr25 456 20 . . . cord-024189-t7mbsr25 457 1 Because because IN cord-024189-t7mbsr25 457 2 of of IN cord-024189-t7mbsr25 457 3 the the DT cord-024189-t7mbsr25 457 4 highly highly RB cord-024189-t7mbsr25 457 5 vascular vascular JJ cord-024189-t7mbsr25 457 6 nature nature NN cord-024189-t7mbsr25 457 7 of of IN cord-024189-t7mbsr25 457 8 muscle muscle NN cord-024189-t7mbsr25 457 9 , , , cord-024189-t7mbsr25 457 10 biopsies biopsy NNS cord-024189-t7mbsr25 457 11 of of IN cord-024189-t7mbsr25 457 12 this this DT cord-024189-t7mbsr25 457 13 organ organ NN cord-024189-t7mbsr25 457 14 may may MD cord-024189-t7mbsr25 457 15 yield yield VB cord-024189-t7mbsr25 457 16 proof proof NN cord-024189-t7mbsr25 457 17 of of IN cord-024189-t7mbsr25 457 18 vasculitis vasculitis NN cord-024189-t7mbsr25 457 19 even even RB cord-024189-t7mbsr25 457 20 in in IN cord-024189-t7mbsr25 457 21 the the DT cord-024189-t7mbsr25 457 22 absence absence NN cord-024189-t7mbsr25 457 23 of of IN cord-024189-t7mbsr25 457 24 clinical clinical JJ cord-024189-t7mbsr25 457 25 indications indication NNS cord-024189-t7mbsr25 457 26 of of IN cord-024189-t7mbsr25 457 27 muscle muscle NN cord-024189-t7mbsr25 457 28 involvement involvement NN cord-024189-t7mbsr25 457 29 ( ( -LRB- cord-024189-t7mbsr25 457 30 Figure figure NN cord-024189-t7mbsr25 457 31 21B 21b NN cord-024189-t7mbsr25 457 32 -4 -4 CD cord-024189-t7mbsr25 457 33 ) ) -RRB- cord-024189-t7mbsr25 457 34 . . . cord-024189-t7mbsr25 457 35 _SP cord-024189-t7mbsr25 458 1 Muscle muscle NN cord-024189-t7mbsr25 458 2 biopsy biopsy NN cord-024189-t7mbsr25 458 3 showing show VBG cord-024189-t7mbsr25 458 4 fi fi FW cord-024189-t7mbsr25 458 5 brinoid brinoid FW cord-024189-t7mbsr25 458 6 necrosis necrosis NN cord-024189-t7mbsr25 458 7 within within IN cord-024189-t7mbsr25 458 8 the the DT cord-024189-t7mbsr25 458 9 wall wall NN cord-024189-t7mbsr25 458 10 of of IN cord-024189-t7mbsr25 458 11 a a DT cord-024189-t7mbsr25 458 12 medium medium JJ cord-024189-t7mbsr25 458 13 - - HYPH cord-024189-t7mbsr25 458 14 sized sized JJ cord-024189-t7mbsr25 458 15 muscular muscular JJ cord-024189-t7mbsr25 458 16 artery artery NN cord-024189-t7mbsr25 458 17 . . . cord-024189-t7mbsr25 459 1 Although although IN cord-024189-t7mbsr25 459 2 the the DT cord-024189-t7mbsr25 459 3 patient patient NN cord-024189-t7mbsr25 459 4 had have VBD cord-024189-t7mbsr25 459 5 clinical clinical JJ cord-024189-t7mbsr25 459 6 symptoms symptom NNS cord-024189-t7mbsr25 459 7 of of IN cord-024189-t7mbsr25 459 8 a a DT cord-024189-t7mbsr25 459 9 neuropathy neuropathy NN cord-024189-t7mbsr25 459 10 and and CC cord-024189-t7mbsr25 459 11 nerve nerve NN cord-024189-t7mbsr25 459 12 conduction conduction NN cord-024189-t7mbsr25 459 13 studies study NNS cord-024189-t7mbsr25 459 14 were be VBD cord-024189-t7mbsr25 459 15 consistent consistent JJ cord-024189-t7mbsr25 459 16 with with IN cord-024189-t7mbsr25 459 17 a a DT cord-024189-t7mbsr25 459 18 mononeuritis mononeuritis JJ cord-024189-t7mbsr25 459 19 multiplex multiplex NN cord-024189-t7mbsr25 459 20 , , , cord-024189-t7mbsr25 459 21 the the DT cord-024189-t7mbsr25 459 22 nerve nerve NN cord-024189-t7mbsr25 459 23 biopsy biopsy NN cord-024189-t7mbsr25 459 24 was be VBD cord-024189-t7mbsr25 459 25 negative negative JJ cord-024189-t7mbsr25 459 26 . . . cord-024189-t7mbsr25 460 1 The the DT cord-024189-t7mbsr25 460 2 diagnosis diagnosis NN cord-024189-t7mbsr25 460 3 of of IN cord-024189-t7mbsr25 460 4 polyarteritis polyarteritis NN cord-024189-t7mbsr25 460 5 was be VBD cord-024189-t7mbsr25 460 6 confi confi NNP cord-024189-t7mbsr25 460 7 rmed rme VBN cord-024189-t7mbsr25 460 8 by by IN cord-024189-t7mbsr25 460 9 the the DT cord-024189-t7mbsr25 460 10 muscle muscle NN cord-024189-t7mbsr25 460 11 biopsy biopsy NN cord-024189-t7mbsr25 460 12 . . . cord-024189-t7mbsr25 461 1 ( ( -LRB- cord-024189-t7mbsr25 461 2 Courtesy courtesy NN cord-024189-t7mbsr25 461 3 of of IN cord-024189-t7mbsr25 461 4 Dr. Dr. NNP cord-024189-t7mbsr25 461 5 John John NNP cord-024189-t7mbsr25 461 6 Stone Stone NNP cord-024189-t7mbsr25 461 7 . . . cord-024189-t7mbsr25 461 8 ) ) -RRB- cord-024189-t7mbsr25 462 1 Untreated untreated JJ cord-024189-t7mbsr25 462 2 PAN PAN NNP cord-024189-t7mbsr25 462 3 has have VBZ cord-024189-t7mbsr25 462 4 a a DT cord-024189-t7mbsr25 462 5 high high JJ cord-024189-t7mbsr25 462 6 mortality mortality NN cord-024189-t7mbsr25 462 7 , , , cord-024189-t7mbsr25 462 8 with with IN cord-024189-t7mbsr25 462 9 an an DT cord-024189-t7mbsr25 462 10 estimated estimate VBN cord-024189-t7mbsr25 462 11 5-year 5-year CD cord-024189-t7mbsr25 462 12 survival survival NN cord-024189-t7mbsr25 462 13 of of IN cord-024189-t7mbsr25 462 14 13 13 CD cord-024189-t7mbsr25 462 15 % % NN cord-024189-t7mbsr25 462 16 prior prior RB cord-024189-t7mbsr25 462 17 to to IN cord-024189-t7mbsr25 462 18 the the DT cord-024189-t7mbsr25 462 19 introduction introduction NN cord-024189-t7mbsr25 462 20 of of IN cord-024189-t7mbsr25 462 21 glucocorticoids glucocorticoid NNS cord-024189-t7mbsr25 462 22 . . . cord-024189-t7mbsr25 463 1 With with IN cord-024189-t7mbsr25 463 2 current current JJ cord-024189-t7mbsr25 463 3 treatment treatment NN cord-024189-t7mbsr25 463 4 , , , cord-024189-t7mbsr25 463 5 survival survival NN cord-024189-t7mbsr25 463 6 is be VBZ cord-024189-t7mbsr25 463 7 greatly greatly RB cord-024189-t7mbsr25 463 8 improved improve VBN cord-024189-t7mbsr25 463 9 , , , cord-024189-t7mbsr25 463 10 approximately approximately RB cord-024189-t7mbsr25 463 11 80 80 CD cord-024189-t7mbsr25 463 12 % % NN cord-024189-t7mbsr25 463 13 at at IN cord-024189-t7mbsr25 463 14 5 5 CD cord-024189-t7mbsr25 463 15 years year NNS cord-024189-t7mbsr25 463 16 . . . cord-024189-t7mbsr25 464 1 In in IN cord-024189-t7mbsr25 464 2 a a DT cord-024189-t7mbsr25 464 3 population population NN cord-024189-t7mbsr25 464 4 of of IN cord-024189-t7mbsr25 464 5 278 278 CD cord-024189-t7mbsr25 464 6 patients patient NNS cord-024189-t7mbsr25 464 7 enrolled enrol VBN cord-024189-t7mbsr25 464 8 in in IN cord-024189-t7mbsr25 464 9 prospective prospective JJ cord-024189-t7mbsr25 464 10 trials trial NNS cord-024189-t7mbsr25 464 11 for for IN cord-024189-t7mbsr25 464 12 PAN PAN NNP cord-024189-t7mbsr25 464 13 , , , cord-024189-t7mbsr25 464 14 MPA MPA NNP cord-024189-t7mbsr25 464 15 , , , cord-024189-t7mbsr25 464 16 and and CC cord-024189-t7mbsr25 464 17 Churg Churg NNP cord-024189-t7mbsr25 464 18 - - HYPH cord-024189-t7mbsr25 464 19 Strauss Strauss NNP cord-024189-t7mbsr25 464 20 syndrome syndrome NN cord-024189-t7mbsr25 464 21 , , , cord-024189-t7mbsr25 464 22 approximately approximately RB cord-024189-t7mbsr25 464 23 75 75 CD cord-024189-t7mbsr25 464 24 % % NN cord-024189-t7mbsr25 464 25 of of IN cord-024189-t7mbsr25 464 26 the the DT cord-024189-t7mbsr25 464 27 deaths death NNS cord-024189-t7mbsr25 464 28 occurred occur VBD cord-024189-t7mbsr25 464 29 during during IN cord-024189-t7mbsr25 464 30 the the DT cord-024189-t7mbsr25 464 31 fi fi NNP cord-024189-t7mbsr25 464 32 rst rst NNP cord-024189-t7mbsr25 464 33 18 18 CD cord-024189-t7mbsr25 464 34 months month NNS cord-024189-t7mbsr25 464 35 after after IN cord-024189-t7mbsr25 464 36 the the DT cord-024189-t7mbsr25 464 37 diagnosis diagnosis NN cord-024189-t7mbsr25 464 38 was be VBD cord-024189-t7mbsr25 464 39 made make VBN cord-024189-t7mbsr25 464 40 and and CC cord-024189-t7mbsr25 464 41 treatment treatment NN cord-024189-t7mbsr25 464 42 initiated initiate VBN cord-024189-t7mbsr25 464 43 . . . cord-024189-t7mbsr25 465 1 Of of IN cord-024189-t7mbsr25 465 2 the the DT cord-024189-t7mbsr25 465 3 patients patient NNS cord-024189-t7mbsr25 465 4 who who WP cord-024189-t7mbsr25 465 5 died die VBD cord-024189-t7mbsr25 465 6 , , , cord-024189-t7mbsr25 465 7 26 26 CD cord-024189-t7mbsr25 465 8 % % NN cord-024189-t7mbsr25 465 9 died die VBD cord-024189-t7mbsr25 465 10 from from IN cord-024189-t7mbsr25 465 11 progression progression NN cord-024189-t7mbsr25 465 12 of of IN cord-024189-t7mbsr25 465 13 their -PRON- PRP$ cord-024189-t7mbsr25 465 14 vasculitis vasculitis NN cord-024189-t7mbsr25 465 15 , , , cord-024189-t7mbsr25 465 16 while while IN cord-024189-t7mbsr25 465 17 13 13 CD cord-024189-t7mbsr25 465 18 % % NN cord-024189-t7mbsr25 465 19 died die VBD cord-024189-t7mbsr25 465 20 of of IN cord-024189-t7mbsr25 465 21 infectious infectious JJ cord-024189-t7mbsr25 465 22 complications complication NNS cord-024189-t7mbsr25 465 23 related relate VBN cord-024189-t7mbsr25 465 24 to to IN cord-024189-t7mbsr25 465 25 treatment treatment NN cord-024189-t7mbsr25 465 26 . . . cord-024189-t7mbsr25 466 1 No no DT cord-024189-t7mbsr25 466 2 major major JJ cord-024189-t7mbsr25 466 3 differences difference NNS cord-024189-t7mbsr25 466 4 were be VBD cord-024189-t7mbsr25 466 5 seen see VBN cord-024189-t7mbsr25 466 6 among among IN cord-024189-t7mbsr25 466 7 the the DT cord-024189-t7mbsr25 466 8 three three CD cord-024189-t7mbsr25 466 9 vasculitides vasculitide NNS cord-024189-t7mbsr25 466 10 studied study VBD cord-024189-t7mbsr25 466 11 ( ( -LRB- cord-024189-t7mbsr25 466 12 11 11 CD cord-024189-t7mbsr25 466 13 ) ) -RRB- cord-024189-t7mbsr25 466 14 . . . cord-024189-t7mbsr25 467 1 Not not RB cord-024189-t7mbsr25 467 2 surprisingly surprisingly RB cord-024189-t7mbsr25 467 3 , , , cord-024189-t7mbsr25 467 4 more more RBR cord-024189-t7mbsr25 467 5 severe severe JJ cord-024189-t7mbsr25 467 6 disease disease NN cord-024189-t7mbsr25 467 7 is be VBZ cord-024189-t7mbsr25 467 8 associated associate VBN cord-024189-t7mbsr25 467 9 with with IN cord-024189-t7mbsr25 467 10 increased increase VBN cord-024189-t7mbsr25 467 11 mortality mortality NN cord-024189-t7mbsr25 467 12 . . . cord-024189-t7mbsr25 468 1 A a DT cord-024189-t7mbsr25 468 2 Five five CD cord-024189-t7mbsr25 468 3 Factor factor NN cord-024189-t7mbsr25 468 4 Score Score NNP cord-024189-t7mbsr25 468 5 has have VBZ cord-024189-t7mbsr25 468 6 been be VBN cord-024189-t7mbsr25 468 7 used use VBN cord-024189-t7mbsr25 468 8 to to TO cord-024189-t7mbsr25 468 9 classify classify VB cord-024189-t7mbsr25 468 10 disease disease NN cord-024189-t7mbsr25 468 11 severity severity NN cord-024189-t7mbsr25 468 12 ( ( -LRB- cord-024189-t7mbsr25 468 13 12 12 CD cord-024189-t7mbsr25 468 14 ) ) -RRB- cord-024189-t7mbsr25 468 15 . . . cord-024189-t7mbsr25 469 1 The the DT cord-024189-t7mbsr25 469 2 fi fi NN cord-024189-t7mbsr25 469 3 ve ve NN cord-024189-t7mbsr25 469 4 factors factor NNS cord-024189-t7mbsr25 469 5 are be VBP cord-024189-t7mbsr25 469 6 ( ( -LRB- cord-024189-t7mbsr25 469 7 1 1 LS cord-024189-t7mbsr25 469 8 ) ) -RRB- cord-024189-t7mbsr25 469 9 proteinuria proteinuria NN cord-024189-t7mbsr25 469 10 > > XX cord-024189-t7mbsr25 469 11 1 1 CD cord-024189-t7mbsr25 469 12 g g NN cord-024189-t7mbsr25 469 13 / / SYM cord-024189-t7mbsr25 469 14 day day NN cord-024189-t7mbsr25 469 15 , , , cord-024189-t7mbsr25 469 16 ( ( -LRB- cord-024189-t7mbsr25 469 17 2 2 LS cord-024189-t7mbsr25 469 18 ) ) -RRB- cord-024189-t7mbsr25 469 19 renal renal JJ cord-024189-t7mbsr25 469 20 insuffi insuffi NN cord-024189-t7mbsr25 469 21 ciency ciency NN cord-024189-t7mbsr25 469 22 ( ( -LRB- cord-024189-t7mbsr25 469 23 Cr Cr NNP cord-024189-t7mbsr25 469 24 > > XX cord-024189-t7mbsr25 469 25 1.6 1.6 CD cord-024189-t7mbsr25 469 26 mg mg NNP cord-024189-t7mbsr25 469 27 / / SYM cord-024189-t7mbsr25 469 28 dL dl NN cord-024189-t7mbsr25 469 29 ) ) -RRB- cord-024189-t7mbsr25 469 30 , , , cord-024189-t7mbsr25 469 31 ( ( -LRB- cord-024189-t7mbsr25 469 32 3 3 LS cord-024189-t7mbsr25 469 33 ) ) -RRB- cord-024189-t7mbsr25 469 34 cardiomyopathy cardiomyopathy NN cord-024189-t7mbsr25 469 35 , , , cord-024189-t7mbsr25 469 36 ( ( -LRB- cord-024189-t7mbsr25 469 37 4 4 LS cord-024189-t7mbsr25 469 38 ) ) -RRB- cord-024189-t7mbsr25 469 39 gastrointestinal gastrointestinal JJ cord-024189-t7mbsr25 469 40 symptoms symptom NNS cord-024189-t7mbsr25 469 41 , , , cord-024189-t7mbsr25 469 42 and and CC cord-024189-t7mbsr25 469 43 ( ( -LRB- cord-024189-t7mbsr25 469 44 5 5 LS cord-024189-t7mbsr25 469 45 ) ) -RRB- cord-024189-t7mbsr25 469 46 CNS CNS NNP cord-024189-t7mbsr25 469 47 involvement involvement NN cord-024189-t7mbsr25 469 48 . . . cord-024189-t7mbsr25 470 1 A a DT cord-024189-t7mbsr25 470 2 Five five CD cord-024189-t7mbsr25 470 3 Factor factor NN cord-024189-t7mbsr25 470 4 Score score NN cord-024189-t7mbsr25 470 5 of of IN cord-024189-t7mbsr25 470 6 0 0 CD cord-024189-t7mbsr25 470 7 is be VBZ cord-024189-t7mbsr25 470 8 associated associate VBN cord-024189-t7mbsr25 470 9 with with IN cord-024189-t7mbsr25 470 10 a a DT cord-024189-t7mbsr25 470 11 5-year 5-year CD cord-024189-t7mbsr25 470 12 mortality mortality NN cord-024189-t7mbsr25 470 13 of of IN cord-024189-t7mbsr25 470 14 only only RB cord-024189-t7mbsr25 470 15 13 13 CD cord-024189-t7mbsr25 470 16 % % NN cord-024189-t7mbsr25 470 17 ( ( -LRB- cord-024189-t7mbsr25 470 18 with with IN cord-024189-t7mbsr25 470 19 not not RB cord-024189-t7mbsr25 470 20 all all DT cord-024189-t7mbsr25 470 21 deaths death NNS cord-024189-t7mbsr25 470 22 caused cause VBN cord-024189-t7mbsr25 470 23 directly directly RB cord-024189-t7mbsr25 470 24 by by IN cord-024189-t7mbsr25 470 25 PAN PAN NNP cord-024189-t7mbsr25 470 26 ) ) -RRB- cord-024189-t7mbsr25 470 27 . . . cord-024189-t7mbsr25 471 1 Five five CD cord-024189-t7mbsr25 471 2 Factor factor NN cord-024189-t7mbsr25 471 3 Scores score NNS cord-024189-t7mbsr25 471 4 of of IN cord-024189-t7mbsr25 471 5 1 1 CD cord-024189-t7mbsr25 471 6 and and CC cord-024189-t7mbsr25 471 7 2 2 CD cord-024189-t7mbsr25 471 8 or or CC cord-024189-t7mbsr25 471 9 more more JJR cord-024189-t7mbsr25 471 10 are be VBP cord-024189-t7mbsr25 471 11 associated associate VBN cord-024189-t7mbsr25 471 12 with with IN cord-024189-t7mbsr25 471 13 mortalities mortality NNS cord-024189-t7mbsr25 471 14 of of IN cord-024189-t7mbsr25 471 15 26 26 CD cord-024189-t7mbsr25 471 16 % % NN cord-024189-t7mbsr25 471 17 and and CC cord-024189-t7mbsr25 471 18 46 46 CD cord-024189-t7mbsr25 471 19 % % NN cord-024189-t7mbsr25 471 20 , , , cord-024189-t7mbsr25 471 21 respectively respectively RB cord-024189-t7mbsr25 471 22 ( ( -LRB- cord-024189-t7mbsr25 471 23 12 12 CD cord-024189-t7mbsr25 471 24 ) ) -RRB- cord-024189-t7mbsr25 471 25 . . . cord-024189-t7mbsr25 472 1 The the DT cord-024189-t7mbsr25 472 2 treatment treatment NN cord-024189-t7mbsr25 472 3 of of IN cord-024189-t7mbsr25 472 4 PAN PAN NNP cord-024189-t7mbsr25 472 5 is be VBZ cord-024189-t7mbsr25 472 6 guided guide VBN cord-024189-t7mbsr25 472 7 by by IN cord-024189-t7mbsr25 472 8 both both CC cord-024189-t7mbsr25 472 9 the the DT cord-024189-t7mbsr25 472 10 etiology etiology NN cord-024189-t7mbsr25 472 11 of of IN cord-024189-t7mbsr25 472 12 the the DT cord-024189-t7mbsr25 472 13 disease disease NN cord-024189-t7mbsr25 472 14 ( ( -LRB- cord-024189-t7mbsr25 472 15 if if IN cord-024189-t7mbsr25 472 16 known know VBN cord-024189-t7mbsr25 472 17 ) ) -RRB- cord-024189-t7mbsr25 472 18 and and CC cord-024189-t7mbsr25 472 19 its -PRON- PRP$ cord-024189-t7mbsr25 472 20 severity severity NN cord-024189-t7mbsr25 472 21 . . . cord-024189-t7mbsr25 473 1 PAN pan NN cord-024189-t7mbsr25 473 2 cases case NNS cord-024189-t7mbsr25 473 3 associated associate VBN cord-024189-t7mbsr25 473 4 with with IN cord-024189-t7mbsr25 473 5 hepatitis hepatitis NN cord-024189-t7mbsr25 473 6 B B NNP cord-024189-t7mbsr25 473 7 are be VBP cord-024189-t7mbsr25 473 8 treated treat VBN cord-024189-t7mbsr25 473 9 with with IN cord-024189-t7mbsr25 473 10 a a DT cord-024189-t7mbsr25 473 11 short short JJ cord-024189-t7mbsr25 473 12 course course NN cord-024189-t7mbsr25 473 13 of of IN cord-024189-t7mbsr25 473 14 prednisone prednisone NNP cord-024189-t7mbsr25 473 15 ( ( -LRB- cord-024189-t7mbsr25 473 16 1 1 CD cord-024189-t7mbsr25 473 17 mg mg NNP cord-024189-t7mbsr25 473 18 / / SYM cord-024189-t7mbsr25 473 19 kg kg NNP cord-024189-t7mbsr25 473 20 / / SYM cord-024189-t7mbsr25 473 21 day day NN cord-024189-t7mbsr25 473 22 ) ) -RRB- cord-024189-t7mbsr25 473 23 to to TO cord-024189-t7mbsr25 473 24 suppress suppress VB cord-024189-t7mbsr25 473 25 the the DT cord-024189-t7mbsr25 473 26 infl infl NN cord-024189-t7mbsr25 473 27 ammation ammation NN cord-024189-t7mbsr25 473 28 . . . cord-024189-t7mbsr25 474 1 Patients patient NNS cord-024189-t7mbsr25 474 2 begin begin VBP cord-024189-t7mbsr25 474 3 6-week 6-week JJ cord-024189-t7mbsr25 474 4 courses course NNS cord-024189-t7mbsr25 474 5 of of IN cord-024189-t7mbsr25 474 6 plasma plasma NN cord-024189-t7mbsr25 474 7 exchange exchange NN cord-024189-t7mbsr25 474 8 ( ( -LRB- cord-024189-t7mbsr25 474 9 approximately approximately RB cord-024189-t7mbsr25 474 10 three three CD cord-024189-t7mbsr25 474 11 exchanges exchange NNS cord-024189-t7mbsr25 474 12 per per IN cord-024189-t7mbsr25 474 13 week week NN cord-024189-t7mbsr25 474 14 ) ) -RRB- cord-024189-t7mbsr25 474 15 simultaneously simultaneously RB cord-024189-t7mbsr25 474 16 with with IN cord-024189-t7mbsr25 474 17 the the DT cord-024189-t7mbsr25 474 18 start start NN cord-024189-t7mbsr25 474 19 of of IN cord-024189-t7mbsr25 474 20 glucocorticoids glucocorticoid NNS cord-024189-t7mbsr25 474 21 . . . cord-024189-t7mbsr25 475 1 The the DT cord-024189-t7mbsr25 475 2 dose dose NN cord-024189-t7mbsr25 475 3 of of IN cord-024189-t7mbsr25 475 4 prednisone prednisone NN cord-024189-t7mbsr25 475 5 is be VBZ cord-024189-t7mbsr25 475 6 tapered taper VBN cord-024189-t7mbsr25 475 7 rapidly rapidly RB cord-024189-t7mbsr25 475 8 ( ( -LRB- cord-024189-t7mbsr25 475 9 over over IN cord-024189-t7mbsr25 475 10 approximately approximately RB cord-024189-t7mbsr25 475 11 2 2 CD cord-024189-t7mbsr25 475 12 weeks week NNS cord-024189-t7mbsr25 475 13 ) ) -RRB- cord-024189-t7mbsr25 475 14 , , , cord-024189-t7mbsr25 475 15 followed follow VBN cord-024189-t7mbsr25 475 16 by by IN cord-024189-t7mbsr25 475 17 the the DT cord-024189-t7mbsr25 475 18 initiation initiation NN cord-024189-t7mbsr25 475 19 of of IN cord-024189-t7mbsr25 475 20 antiviral antiviral JJ cord-024189-t7mbsr25 475 21 therapy therapy NN cord-024189-t7mbsr25 475 22 ( ( -LRB- cord-024189-t7mbsr25 475 23 e.g. e.g. RB cord-024189-t7mbsr25 475 24 , , , cord-024189-t7mbsr25 475 25 lamivudine lamivudine NNP cord-024189-t7mbsr25 475 26 100 100 CD cord-024189-t7mbsr25 475 27 mg mg NNP cord-024189-t7mbsr25 475 28 / / SYM cord-024189-t7mbsr25 475 29 day day NN cord-024189-t7mbsr25 475 30 ) ) -RRB- cord-024189-t7mbsr25 475 31 . . . cord-024189-t7mbsr25 476 1 For for IN cord-024189-t7mbsr25 476 2 idiopathic idiopathic JJ cord-024189-t7mbsr25 476 3 PAN PAN NNP cord-024189-t7mbsr25 476 4 , , , cord-024189-t7mbsr25 476 5 the the DT cord-024189-t7mbsr25 476 6 mainstay mainstay NN cord-024189-t7mbsr25 476 7 of of IN cord-024189-t7mbsr25 476 8 treatment treatment NN cord-024189-t7mbsr25 476 9 is be VBZ cord-024189-t7mbsr25 476 10 glucocorticoids glucocorticoid NNS cord-024189-t7mbsr25 476 11 , , , cord-024189-t7mbsr25 476 12 with with IN cord-024189-t7mbsr25 476 13 an an DT cord-024189-t7mbsr25 476 14 initial initial JJ cord-024189-t7mbsr25 476 15 dose dose NN cord-024189-t7mbsr25 476 16 of of IN cord-024189-t7mbsr25 476 17 approximately approximately RB cord-024189-t7mbsr25 476 18 1 1 CD cord-024189-t7mbsr25 476 19 mg/ mg/ NN cord-024189-t7mbsr25 476 20 kg kg NNP cord-024189-t7mbsr25 476 21 daily daily RB cord-024189-t7mbsr25 476 22 of of IN cord-024189-t7mbsr25 476 23 prednisone prednisone NNP cord-024189-t7mbsr25 476 24 . . . cord-024189-t7mbsr25 477 1 Intravenous intravenous JJ cord-024189-t7mbsr25 477 2 glucocorticoids glucocorticoid NNS cord-024189-t7mbsr25 477 3 can can MD cord-024189-t7mbsr25 477 4 be be VB cord-024189-t7mbsr25 477 5 used use VBN cord-024189-t7mbsr25 477 6 in in IN cord-024189-t7mbsr25 477 7 patients patient NNS cord-024189-t7mbsr25 477 8 with with IN cord-024189-t7mbsr25 477 9 diffi diffi NNP cord-024189-t7mbsr25 477 10 culty culty NNP cord-024189-t7mbsr25 477 11 taking take VBG cord-024189-t7mbsr25 477 12 oral oral JJ cord-024189-t7mbsr25 477 13 medications medication NNS cord-024189-t7mbsr25 477 14 due due JJ cord-024189-t7mbsr25 477 15 to to IN cord-024189-t7mbsr25 477 16 GI GI NNP cord-024189-t7mbsr25 477 17 involvement involvement NN cord-024189-t7mbsr25 477 18 . . . cord-024189-t7mbsr25 478 1 Pulse pulse NN cord-024189-t7mbsr25 478 2 doses dose NNS cord-024189-t7mbsr25 478 3 ( ( -LRB- cord-024189-t7mbsr25 478 4 e.g. e.g. RB cord-024189-t7mbsr25 478 5 , , , cord-024189-t7mbsr25 478 6 methylprednisolone methylprednisolone NN cord-024189-t7mbsr25 478 7 1 1 CD cord-024189-t7mbsr25 478 8 g g NN cord-024189-t7mbsr25 478 9 intravenously intravenously RB cord-024189-t7mbsr25 478 10 each each DT cord-024189-t7mbsr25 478 11 day day NN cord-024189-t7mbsr25 478 12 times time NNS cord-024189-t7mbsr25 478 13 three three CD cord-024189-t7mbsr25 478 14 ) ) -RRB- cord-024189-t7mbsr25 478 15 may may MD cord-024189-t7mbsr25 478 16 be be VB cord-024189-t7mbsr25 478 17 used use VBN cord-024189-t7mbsr25 478 18 in in IN cord-024189-t7mbsr25 478 19 severe severe JJ cord-024189-t7mbsr25 478 20 disease disease NN cord-024189-t7mbsr25 478 21 . . . cord-024189-t7mbsr25 479 1 Glucocorticoids Glucocorticoids NNP cord-024189-t7mbsr25 479 2 alone alone RB cord-024189-t7mbsr25 479 3 may may MD cord-024189-t7mbsr25 479 4 be be VB cord-024189-t7mbsr25 479 5 enough enough JJ cord-024189-t7mbsr25 479 6 to to TO cord-024189-t7mbsr25 479 7 treat treat VB cord-024189-t7mbsr25 479 8 milder mild JJR cord-024189-t7mbsr25 479 9 cases case NNS cord-024189-t7mbsr25 479 10 . . . cord-024189-t7mbsr25 480 1 Approximately approximately RB cord-024189-t7mbsr25 480 2 half half NN cord-024189-t7mbsr25 480 3 of of IN cord-024189-t7mbsr25 480 4 all all DT cord-024189-t7mbsr25 480 5 patients patient NNS cord-024189-t7mbsr25 480 6 with with IN cord-024189-t7mbsr25 480 7 PAN PAN NNP cord-024189-t7mbsr25 480 8 may may MD cord-024189-t7mbsr25 480 9 be be VB cord-024189-t7mbsr25 480 10 cured cure VBN cord-024189-t7mbsr25 480 11 with with IN cord-024189-t7mbsr25 480 12 glucocorticoids glucocorticoid NNS cord-024189-t7mbsr25 480 13 alone alone RB cord-024189-t7mbsr25 480 14 . . . cord-024189-t7mbsr25 481 1 In in IN cord-024189-t7mbsr25 481 2 cases case NNS cord-024189-t7mbsr25 481 3 of of IN cord-024189-t7mbsr25 481 4 PAN PAN NNP cord-024189-t7mbsr25 481 5 that that WDT cord-024189-t7mbsr25 481 6 are be VBP cord-024189-t7mbsr25 481 7 rapidly rapidly RB cord-024189-t7mbsr25 481 8 progressive progressive JJ cord-024189-t7mbsr25 481 9 or or CC cord-024189-t7mbsr25 481 10 lifeor lifeor JJ cord-024189-t7mbsr25 481 11 organ organ NN cord-024189-t7mbsr25 481 12 - - HYPH cord-024189-t7mbsr25 481 13 threatening threaten VBG cord-024189-t7mbsr25 481 14 , , , cord-024189-t7mbsr25 481 15 cyclophosphamide cyclophosphamide RB cord-024189-t7mbsr25 481 16 is be VBZ cord-024189-t7mbsr25 481 17 added add VBN cord-024189-t7mbsr25 481 18 to to IN cord-024189-t7mbsr25 481 19 glucocorticoid glucocorticoid NN cord-024189-t7mbsr25 481 20 treatment treatment NN cord-024189-t7mbsr25 481 21 . . . cord-024189-t7mbsr25 482 1 Cyclophosphamide Cyclophosphamide NNP cord-024189-t7mbsr25 482 2 should should MD cord-024189-t7mbsr25 482 3 be be VB cord-024189-t7mbsr25 482 4 considered consider VBN cord-024189-t7mbsr25 482 5 for for IN cord-024189-t7mbsr25 482 6 any any DT cord-024189-t7mbsr25 482 7 patient patient NN cord-024189-t7mbsr25 482 8 with with IN cord-024189-t7mbsr25 482 9 a a DT cord-024189-t7mbsr25 482 10 Five five CD cord-024189-t7mbsr25 482 11 Factor Factor NNP cord-024189-t7mbsr25 482 12 Score score NN cord-024189-t7mbsr25 482 13 of of IN cord-024189-t7mbsr25 482 14 1 1 CD cord-024189-t7mbsr25 482 15 or or CC cord-024189-t7mbsr25 482 16 greater great JJR cord-024189-t7mbsr25 482 17 . . . cord-024189-t7mbsr25 483 1 In in IN cord-024189-t7mbsr25 483 2 addition addition NN cord-024189-t7mbsr25 483 3 , , , cord-024189-t7mbsr25 483 4 severe severe JJ cord-024189-t7mbsr25 483 5 peripheral peripheral JJ cord-024189-t7mbsr25 483 6 neuropathy neuropathy NN cord-024189-t7mbsr25 483 7 or or CC cord-024189-t7mbsr25 483 8 mononeuritis mononeuritis NN cord-024189-t7mbsr25 483 9 multiplex multiplex NN cord-024189-t7mbsr25 483 10 is be VBZ cord-024189-t7mbsr25 483 11 also also RB cord-024189-t7mbsr25 483 12 a a DT cord-024189-t7mbsr25 483 13 strong strong JJ cord-024189-t7mbsr25 483 14 indication indication NN cord-024189-t7mbsr25 483 15 for for IN cord-024189-t7mbsr25 483 16 cyclophosphamide cyclophosphamide NN cord-024189-t7mbsr25 483 17 . . . cord-024189-t7mbsr25 484 1 Although although IN cord-024189-t7mbsr25 484 2 many many JJ cord-024189-t7mbsr25 484 3 clinicians clinician NNS cord-024189-t7mbsr25 484 4 still still RB cord-024189-t7mbsr25 484 5 prefer prefer VBP cord-024189-t7mbsr25 484 6 daily daily JJ cord-024189-t7mbsr25 484 7 oral oral JJ cord-024189-t7mbsr25 484 8 cyclophosphamide cyclophosphamide NN cord-024189-t7mbsr25 484 9 to to TO cord-024189-t7mbsr25 484 10 monthly monthly VB cord-024189-t7mbsr25 484 11 pulsed pulse VBN cord-024189-t7mbsr25 484 12 intravenous intravenous JJ cord-024189-t7mbsr25 484 13 cyclophosphamide cyclophosphamide NN cord-024189-t7mbsr25 484 14 , , , cord-024189-t7mbsr25 484 15 a a DT cord-024189-t7mbsr25 484 16 meta meta JJ cord-024189-t7mbsr25 484 17 - - HYPH cord-024189-t7mbsr25 484 18 analysis analysis NN cord-024189-t7mbsr25 484 19 comparing compare VBG cord-024189-t7mbsr25 484 20 the the DT cord-024189-t7mbsr25 484 21 two two CD cord-024189-t7mbsr25 484 22 regimens regimen NNS cord-024189-t7mbsr25 484 23 in in IN cord-024189-t7mbsr25 484 24 ANCA ANCA NNP cord-024189-t7mbsr25 484 25 - - HYPH cord-024189-t7mbsr25 484 26 associated associate VBN cord-024189-t7mbsr25 484 27 vasculitis vasculitis NN cord-024189-t7mbsr25 484 28 showed show VBD cord-024189-t7mbsr25 484 29 little little JJ cord-024189-t7mbsr25 484 30 difference difference NN cord-024189-t7mbsr25 484 31 ( ( -LRB- cord-024189-t7mbsr25 484 32 13 13 CD cord-024189-t7mbsr25 484 33 ) ) -RRB- cord-024189-t7mbsr25 484 34 . . . cord-024189-t7mbsr25 485 1 Therapy therapy NN cord-024189-t7mbsr25 485 2 should should MD cord-024189-t7mbsr25 485 3 be be VB cord-024189-t7mbsr25 485 4 tailored tailor VBN cord-024189-t7mbsr25 485 5 to to IN cord-024189-t7mbsr25 485 6 the the DT cord-024189-t7mbsr25 485 7 individual individual JJ cord-024189-t7mbsr25 485 8 patient patient NN cord-024189-t7mbsr25 485 9 's 's POS cord-024189-t7mbsr25 485 10 circumstances circumstance NNS cord-024189-t7mbsr25 485 11 . . . cord-024189-t7mbsr25 486 1 Most Most JJS cord-024189-t7mbsr25 486 2 cases case NNS cord-024189-t7mbsr25 486 3 of of IN cord-024189-t7mbsr25 486 4 idiopathic idiopathic JJ cord-024189-t7mbsr25 486 5 PAN PAN NNP cord-024189-t7mbsr25 486 6 do do VBP cord-024189-t7mbsr25 486 7 not not RB cord-024189-t7mbsr25 486 8 recur recur VB cord-024189-t7mbsr25 486 9 after after IN cord-024189-t7mbsr25 486 10 remission remission NN cord-024189-t7mbsr25 486 11 has have VBZ cord-024189-t7mbsr25 486 12 been be VBN cord-024189-t7mbsr25 486 13 achieved achieve VBN cord-024189-t7mbsr25 486 14 and and CC cord-024189-t7mbsr25 486 15 the the DT cord-024189-t7mbsr25 486 16 patient patient NN cord-024189-t7mbsr25 486 17 has have VBZ cord-024189-t7mbsr25 486 18 received receive VBN cord-024189-t7mbsr25 486 19 6 6 CD cord-024189-t7mbsr25 486 20 to to TO cord-024189-t7mbsr25 486 21 12 12 CD cord-024189-t7mbsr25 486 22 months month NNS cord-024189-t7mbsr25 486 23 of of IN cord-024189-t7mbsr25 486 24 cyclophosphamide cyclophosphamide NN cord-024189-t7mbsr25 486 25 . . . cord-024189-t7mbsr25 487 1 Current current JJ cord-024189-t7mbsr25 487 2 regimens regimen NNS cord-024189-t7mbsr25 487 3 generally generally RB cord-024189-t7mbsr25 487 4 emphasize emphasize VBP cord-024189-t7mbsr25 487 5 shorter short JJR cord-024189-t7mbsr25 487 6 courses course NNS cord-024189-t7mbsr25 487 7 of of IN cord-024189-t7mbsr25 487 8 cyclophosphamide cyclophosphamide NN cord-024189-t7mbsr25 487 9 , , , cord-024189-t7mbsr25 487 10 with with IN cord-024189-t7mbsr25 487 11 durations duration NNS cord-024189-t7mbsr25 487 12 of of IN cord-024189-t7mbsr25 487 13 therapy therapy NN cord-024189-t7mbsr25 487 14 closer close RBR cord-024189-t7mbsr25 487 15 to to IN cord-024189-t7mbsr25 487 16 6 6 CD cord-024189-t7mbsr25 487 17 months month NNS cord-024189-t7mbsr25 487 18 than than IN cord-024189-t7mbsr25 487 19 to to IN cord-024189-t7mbsr25 487 20 12 12 CD cord-024189-t7mbsr25 487 21 . . . cord-024189-t7mbsr25 488 1 After after IN cord-024189-t7mbsr25 488 2 treatment treatment NN cord-024189-t7mbsr25 488 3 with with IN cord-024189-t7mbsr25 488 4 6 6 CD cord-024189-t7mbsr25 488 5 months month NNS cord-024189-t7mbsr25 488 6 of of IN cord-024189-t7mbsr25 488 7 cyclophosphamide cyclophosphamide NN cord-024189-t7mbsr25 488 8 , , , cord-024189-t7mbsr25 488 9 patients patient NNS cord-024189-t7mbsr25 488 10 in in IN cord-024189-t7mbsr25 488 11 remission remission NN cord-024189-t7mbsr25 488 12 - - : cord-024189-t7mbsr25 488 13 the the DT cord-024189-t7mbsr25 488 14 great great JJ cord-024189-t7mbsr25 488 15 majority majority NN cord-024189-t7mbsr25 488 16 - - : cord-024189-t7mbsr25 488 17 should should MD cord-024189-t7mbsr25 488 18 be be VB cord-024189-t7mbsr25 488 19 switched switch VBN cord-024189-t7mbsr25 488 20 to to IN cord-024189-t7mbsr25 488 21 another another DT cord-024189-t7mbsr25 488 22 immunosuppressive immunosuppressive JJ cord-024189-t7mbsr25 488 23 agent agent NN cord-024189-t7mbsr25 488 24 for for IN cord-024189-t7mbsr25 488 25 remission remission NN cord-024189-t7mbsr25 488 26 maintenance maintenance NN cord-024189-t7mbsr25 488 27 . . . cord-024189-t7mbsr25 489 1 As as IN cord-024189-t7mbsr25 489 2 with with IN cord-024189-t7mbsr25 489 3 the the DT cord-024189-t7mbsr25 489 4 ANCA ANCA NNP cord-024189-t7mbsr25 489 5 - - HYPH cord-024189-t7mbsr25 489 6 associated associate VBN cord-024189-t7mbsr25 489 7 vasculitides vasculitide NNS cord-024189-t7mbsr25 489 8 , , , cord-024189-t7mbsr25 489 9 azathioprine azathioprine JJ cord-024189-t7mbsr25 489 10 or or CC cord-024189-t7mbsr25 489 11 methotrexate methotrexate NNP cord-024189-t7mbsr25 489 12 is be VBZ cord-024189-t7mbsr25 489 13 often often RB cord-024189-t7mbsr25 489 14 used use VBN cord-024189-t7mbsr25 489 15 . . . cord-024189-t7mbsr25 490 1 After after IN cord-024189-t7mbsr25 490 2 a a DT cord-024189-t7mbsr25 490 3 total total JJ cord-024189-t7mbsr25 490 4 treatment treatment NN cord-024189-t7mbsr25 490 5 length length NN cord-024189-t7mbsr25 490 6 of of IN cord-024189-t7mbsr25 490 7 approximately approximately RB cord-024189-t7mbsr25 490 8 18 18 CD cord-024189-t7mbsr25 490 9 months month NNS cord-024189-t7mbsr25 490 10 , , , cord-024189-t7mbsr25 490 11 the the DT cord-024189-t7mbsr25 490 12 remission remission NN cord-024189-t7mbsr25 490 13 maintenance maintenance NN cord-024189-t7mbsr25 490 14 agent agent NN cord-024189-t7mbsr25 490 15 can can MD cord-024189-t7mbsr25 490 16 often often RB cord-024189-t7mbsr25 490 17 be be VB cord-024189-t7mbsr25 490 18 stopped stop VBN cord-024189-t7mbsr25 490 19 , , , cord-024189-t7mbsr25 490 20 with with IN cord-024189-t7mbsr25 490 21 a a DT cord-024189-t7mbsr25 490 22 low low JJ cord-024189-t7mbsr25 490 23 relapse relapse NN cord-024189-t7mbsr25 490 24 rate rate NN cord-024189-t7mbsr25 490 25 . . . cord-024189-t7mbsr25 491 1 Patients patient NNS cord-024189-t7mbsr25 491 2 should should MD cord-024189-t7mbsr25 491 3 continue continue VB cord-024189-t7mbsr25 491 4 to to TO cord-024189-t7mbsr25 491 5 be be VB cord-024189-t7mbsr25 491 6 monitored monitor VBN cord-024189-t7mbsr25 491 7 for for IN cord-024189-t7mbsr25 491 8 evidence evidence NN cord-024189-t7mbsr25 491 9 of of IN cord-024189-t7mbsr25 491 10 recurrence recurrence NN cord-024189-t7mbsr25 491 11 . . . cord-024189-t7mbsr25 492 1 Much much JJ cord-024189-t7mbsr25 492 2 potential potential JJ cord-024189-t7mbsr25 492 3 morbidity morbidity NN cord-024189-t7mbsr25 492 4 in in IN cord-024189-t7mbsr25 492 5 PAN PAN NNP cord-024189-t7mbsr25 492 6 relates relate VBZ cord-024189-t7mbsr25 492 7 to to IN cord-024189-t7mbsr25 492 8 adverse adverse JJ cord-024189-t7mbsr25 492 9 events event NNS cord-024189-t7mbsr25 492 10 from from IN cord-024189-t7mbsr25 492 11 inappropriate inappropriate JJ cord-024189-t7mbsr25 492 12 ( ( -LRB- cord-024189-t7mbsr25 492 13 or or CC cord-024189-t7mbsr25 492 14 overly overly RB cord-024189-t7mbsr25 492 15 aggressive aggressive JJ cord-024189-t7mbsr25 492 16 ) ) -RRB- cord-024189-t7mbsr25 492 17 treatment treatment NN cord-024189-t7mbsr25 492 18 . . . cord-024189-t7mbsr25 493 1 Conversely conversely RB cord-024189-t7mbsr25 493 2 , , , cord-024189-t7mbsr25 493 3 poor poor JJ cord-024189-t7mbsr25 493 4 outcomes outcome NNS cord-024189-t7mbsr25 493 5 also also RB cord-024189-t7mbsr25 493 6 result result VBP cord-024189-t7mbsr25 493 7 from from IN cord-024189-t7mbsr25 493 8 undertreatment undertreatment NN cord-024189-t7mbsr25 493 9 , , , cord-024189-t7mbsr25 493 10 for for IN cord-024189-t7mbsr25 493 11 example example NN cord-024189-t7mbsr25 493 12 , , , cord-024189-t7mbsr25 493 13 failure failure NN cord-024189-t7mbsr25 493 14 to to TO cord-024189-t7mbsr25 493 15 employ employ VB cord-024189-t7mbsr25 493 16 cyclophosphamide cyclophosphamide NN cord-024189-t7mbsr25 493 17 in in IN cord-024189-t7mbsr25 493 18 a a DT cord-024189-t7mbsr25 493 19 patient patient NN cord-024189-t7mbsr25 493 20 clearly clearly RB cord-024189-t7mbsr25 493 21 failing fail VBG cord-024189-t7mbsr25 493 22 highdose highdose NN cord-024189-t7mbsr25 493 23 glucocorticoids glucocorticoid NNS cord-024189-t7mbsr25 493 24 . . . cord-024189-t7mbsr25 494 1 An an DT cord-024189-t7mbsr25 494 2 important important JJ cord-024189-t7mbsr25 494 3 aspect aspect NN cord-024189-t7mbsr25 494 4 of of IN cord-024189-t7mbsr25 494 5 treatment treatment NN cord-024189-t7mbsr25 494 6 is be VBZ cord-024189-t7mbsr25 494 7 avoiding avoid VBG cord-024189-t7mbsr25 494 8 known know VBN cord-024189-t7mbsr25 494 9 side side NN cord-024189-t7mbsr25 494 10 effects effect NNS cord-024189-t7mbsr25 494 11 of of IN cord-024189-t7mbsr25 494 12 agents agent NNS cord-024189-t7mbsr25 494 13 used use VBN cord-024189-t7mbsr25 494 14 . . . cord-024189-t7mbsr25 495 1 This this DT cord-024189-t7mbsr25 495 2 includes include VBZ cord-024189-t7mbsr25 495 3 the the DT cord-024189-t7mbsr25 495 4 use use NN cord-024189-t7mbsr25 495 5 of of IN cord-024189-t7mbsr25 495 6 calcium calcium NN cord-024189-t7mbsr25 495 7 and and CC cord-024189-t7mbsr25 495 8 vitamin vitamin NN cord-024189-t7mbsr25 495 9 D d NN cord-024189-t7mbsr25 495 10 supplementation supplementation NN cord-024189-t7mbsr25 495 11 in in IN cord-024189-t7mbsr25 495 12 all all DT cord-024189-t7mbsr25 495 13 patients patient NNS cord-024189-t7mbsr25 495 14 on on IN cord-024189-t7mbsr25 495 15 glucocorticoids glucocorticoid NNS cord-024189-t7mbsr25 495 16 , , , cord-024189-t7mbsr25 495 17 along along IN cord-024189-t7mbsr25 495 18 with with IN cord-024189-t7mbsr25 495 19 use use NN cord-024189-t7mbsr25 495 20 of of IN cord-024189-t7mbsr25 495 21 a a DT cord-024189-t7mbsr25 495 22 bisphosphonate bisphosphonate NN cord-024189-t7mbsr25 495 23 in in IN cord-024189-t7mbsr25 495 24 those those DT cord-024189-t7mbsr25 495 25 at at IN cord-024189-t7mbsr25 495 26 high high JJ cord-024189-t7mbsr25 495 27 risk risk NN cord-024189-t7mbsr25 495 28 for for IN cord-024189-t7mbsr25 495 29 bone bone NN cord-024189-t7mbsr25 495 30 loss loss NN cord-024189-t7mbsr25 495 31 and and CC cord-024189-t7mbsr25 495 32 monitoring monitoring NN cord-024189-t7mbsr25 495 33 of of IN cord-024189-t7mbsr25 495 34 bone bone NN cord-024189-t7mbsr25 495 35 density density NN cord-024189-t7mbsr25 495 36 . . . cord-024189-t7mbsr25 496 1 Patients patient NNS cord-024189-t7mbsr25 496 2 on on IN cord-024189-t7mbsr25 496 3 cyclophosphamide cyclophosphamide NN cord-024189-t7mbsr25 496 4 should should MD cord-024189-t7mbsr25 496 5 have have VB cord-024189-t7mbsr25 496 6 routine routine JJ cord-024189-t7mbsr25 496 7 monitoring monitoring NN cord-024189-t7mbsr25 496 8 for for IN cord-024189-t7mbsr25 496 9 cytopenias cytopenia NNS cord-024189-t7mbsr25 496 10 and and CC cord-024189-t7mbsr25 496 11 hematuria hematuria NN cord-024189-t7mbsr25 496 12 and and CC cord-024189-t7mbsr25 496 13 receive receive VB cord-024189-t7mbsr25 496 14 trimethoprim/ trimethoprim/ NN cord-024189-t7mbsr25 496 15 sulfamethoxazole sulfamethoxazole NN cord-024189-t7mbsr25 496 16 for for IN cord-024189-t7mbsr25 496 17 prevention prevention NN cord-024189-t7mbsr25 496 18 of of IN cord-024189-t7mbsr25 496 19 Pneumocystis Pneumocystis NNP cord-024189-t7mbsr25 496 20 jiroveci jiroveci NNP cord-024189-t7mbsr25 496 21 ( ( -LRB- cord-024189-t7mbsr25 496 22 formerly formerly RB cord-024189-t7mbsr25 496 23 carinii carinii FW cord-024189-t7mbsr25 496 24 ) ) -RRB- cord-024189-t7mbsr25 496 25 pneumonia pneumonia NN cord-024189-t7mbsr25 496 26 . . . cord-024189-t7mbsr25 497 1 Patients patient NNS cord-024189-t7mbsr25 497 2 receiving receive VBG cord-024189-t7mbsr25 497 3 pulsed pulse VBN cord-024189-t7mbsr25 497 4 intravenous intravenous JJ cord-024189-t7mbsr25 497 5 cyclophosphamide cyclophosphamide NN cord-024189-t7mbsr25 497 6 are be VBP cord-024189-t7mbsr25 497 7 also also RB cord-024189-t7mbsr25 497 8 candidates candidate NNS cord-024189-t7mbsr25 497 9 for for IN cord-024189-t7mbsr25 497 10 MESNA MESNA NNP cord-024189-t7mbsr25 497 11 ( ( -LRB- cord-024189-t7mbsr25 497 12 sodium-2-sulfanyl sodium-2-sulfanyl JJ cord-024189-t7mbsr25 497 13 ethanesulfonate ethanesulfonate NN cord-024189-t7mbsr25 497 14 ) ) -RRB- cord-024189-t7mbsr25 498 1 for for IN cord-024189-t7mbsr25 498 2 prevention prevention NN cord-024189-t7mbsr25 498 3 of of IN cord-024189-t7mbsr25 498 4 hemorrhagic hemorrhagic JJ cord-024189-t7mbsr25 498 5 cystitis cystitis NN cord-024189-t7mbsr25 498 6 . . . cord-024189-t7mbsr25 499 1 Premenopausal premenopausal NN cord-024189-t7mbsr25 499 2 females female NNS cord-024189-t7mbsr25 499 3 on on IN cord-024189-t7mbsr25 499 4 cyclophosphamide cyclophosphamide NN cord-024189-t7mbsr25 499 5 are be VBP cord-024189-t7mbsr25 499 6 candidates candidate NNS cord-024189-t7mbsr25 499 7 for for IN cord-024189-t7mbsr25 499 8 leuprolide leuprolide NN cord-024189-t7mbsr25 499 9 to to TO cord-024189-t7mbsr25 499 10 suppress suppress VB cord-024189-t7mbsr25 499 11 the the DT cord-024189-t7mbsr25 499 12 GnRH GnRH NNP cord-024189-t7mbsr25 499 13 axis axis NN cord-024189-t7mbsr25 499 14 and and CC cord-024189-t7mbsr25 499 15 prevent prevent VB cord-024189-t7mbsr25 499 16 premature premature JJ cord-024189-t7mbsr25 499 17 ovarian ovarian JJ cord-024189-t7mbsr25 499 18 failure failure NN cord-024189-t7mbsr25 499 19 ; ; : cord-024189-t7mbsr25 499 20 males male NNS cord-024189-t7mbsr25 499 21 may may MD cord-024189-t7mbsr25 499 22 opt opt VB cord-024189-t7mbsr25 499 23 to to TO cord-024189-t7mbsr25 499 24 bank bank NN cord-024189-t7mbsr25 499 25 sperm sperm NN cord-024189-t7mbsr25 499 26 . . . cord-024189-t7mbsr25 500 1 Finally finally RB cord-024189-t7mbsr25 500 2 , , , cord-024189-t7mbsr25 500 3 as as IN cord-024189-t7mbsr25 500 4 a a DT cord-024189-t7mbsr25 500 5 teratogen teratogen NN cord-024189-t7mbsr25 500 6 , , , cord-024189-t7mbsr25 500 7 patients patient NNS cord-024189-t7mbsr25 500 8 should should MD cord-024189-t7mbsr25 500 9 not not RB cord-024189-t7mbsr25 500 10 become become VB cord-024189-t7mbsr25 500 11 pregnant pregnant JJ cord-024189-t7mbsr25 500 12 or or CC cord-024189-t7mbsr25 500 13 father father NN cord-024189-t7mbsr25 500 14 children child NNS cord-024189-t7mbsr25 500 15 on on IN cord-024189-t7mbsr25 500 16 cyclophosphamide cyclophosphamide NN cord-024189-t7mbsr25 500 17 . . . cord-024189-t7mbsr25 501 1 Multiple multiple JJ cord-024189-t7mbsr25 501 2 antibodies antibody NNS cord-024189-t7mbsr25 501 3 may may MD cord-024189-t7mbsr25 501 4 lead lead VB cord-024189-t7mbsr25 501 5 to to IN cord-024189-t7mbsr25 501 6 positive positive JJ cord-024189-t7mbsr25 501 7 immunofl immunofl NN cord-024189-t7mbsr25 501 8 uorescence uorescence NN cord-024189-t7mbsr25 501 9 testing testing NN cord-024189-t7mbsr25 501 10 for for IN cord-024189-t7mbsr25 501 11 ANCA ANCA NNP cord-024189-t7mbsr25 501 12 in in IN cord-024189-t7mbsr25 501 13 either either DT cord-024189-t7mbsr25 501 14 perinuclear perinuclear NNP cord-024189-t7mbsr25 501 15 ( ( -LRB- cord-024189-t7mbsr25 501 16 P p NN cord-024189-t7mbsr25 501 17 - - HYPH cord-024189-t7mbsr25 501 18 ANCA ANCA NNP cord-024189-t7mbsr25 501 19 ) ) -RRB- cord-024189-t7mbsr25 501 20 or or CC cord-024189-t7mbsr25 501 21 cytoplasmic cytoplasmic JJ cord-024189-t7mbsr25 501 22 ( ( -LRB- cord-024189-t7mbsr25 501 23 C c NN cord-024189-t7mbsr25 501 24 - - HYPH cord-024189-t7mbsr25 501 25 ANCA ANCA NNP cord-024189-t7mbsr25 501 26 ) ) -RRB- cord-024189-t7mbsr25 501 27 patterns pattern NNS cord-024189-t7mbsr25 501 28 . . . cord-024189-t7mbsr25 502 1 However however RB cord-024189-t7mbsr25 502 2 , , , cord-024189-t7mbsr25 502 3 only only RB cord-024189-t7mbsr25 502 4 antibodies antibody NNS cord-024189-t7mbsr25 502 5 to to IN cord-024189-t7mbsr25 502 6 myeloperoxidase myeloperoxidase NNP cord-024189-t7mbsr25 502 7 ( ( -LRB- cord-024189-t7mbsr25 502 8 MPO MPO NNP cord-024189-t7mbsr25 502 9 ) ) -RRB- cord-024189-t7mbsr25 502 10 and and CC cord-024189-t7mbsr25 502 11 proteinase-3 proteinase-3 NNP cord-024189-t7mbsr25 502 12 ( ( -LRB- cord-024189-t7mbsr25 502 13 PR3 PR3 NNP cord-024189-t7mbsr25 502 14 ) ) -RRB- cord-024189-t7mbsr25 502 15 are be VBP cord-024189-t7mbsr25 502 16 associated associate VBN cord-024189-t7mbsr25 502 17 with with IN cord-024189-t7mbsr25 502 18 the the DT cord-024189-t7mbsr25 502 19 AAV AAV NNP cord-024189-t7mbsr25 502 20 . . . cord-024189-t7mbsr25 503 1 Wegener Wegener NNP cord-024189-t7mbsr25 503 2 's 's POS cord-024189-t7mbsr25 503 3 granulomatosis granulomatosis NN cord-024189-t7mbsr25 503 4 may may MD cord-024189-t7mbsr25 503 5 be be VB cord-024189-t7mbsr25 503 6 associated associate VBN cord-024189-t7mbsr25 503 7 with with IN cord-024189-t7mbsr25 503 8 destructive destructive JJ cord-024189-t7mbsr25 503 9 upper upper JJ cord-024189-t7mbsr25 503 10 respiratory respiratory JJ cord-024189-t7mbsr25 503 11 tract tract NN cord-024189-t7mbsr25 503 12 disease disease NN cord-024189-t7mbsr25 503 13 , , , cord-024189-t7mbsr25 503 14 including include VBG cord-024189-t7mbsr25 503 15 saddle saddle NN cord-024189-t7mbsr25 503 16 - - HYPH cord-024189-t7mbsr25 503 17 nose nose NN cord-024189-t7mbsr25 503 18 deformity deformity NN cord-024189-t7mbsr25 503 19 , , , cord-024189-t7mbsr25 503 20 erosive erosive JJ cord-024189-t7mbsr25 503 21 sinusitis sinusitis NN cord-024189-t7mbsr25 503 22 , , , cord-024189-t7mbsr25 503 23 and and CC cord-024189-t7mbsr25 503 24 subglottic subglottic JJ cord-024189-t7mbsr25 503 25 stenosis stenosis NN cord-024189-t7mbsr25 503 26 . . . cord-024189-t7mbsr25 504 1 The the DT cord-024189-t7mbsr25 504 2 CSS css NN cord-024189-t7mbsr25 504 3 is be VBZ cord-024189-t7mbsr25 504 4 often often RB cord-024189-t7mbsr25 504 5 associated associate VBN cord-024189-t7mbsr25 504 6 with with IN cord-024189-t7mbsr25 504 7 allergic allergic JJ cord-024189-t7mbsr25 504 8 rhinitis rhinitis NN cord-024189-t7mbsr25 504 9 , , , cord-024189-t7mbsr25 504 10 nasal nasal NN cord-024189-t7mbsr25 504 11 polyposis polyposis NN cord-024189-t7mbsr25 504 12 , , , cord-024189-t7mbsr25 504 13 or or CC cord-024189-t7mbsr25 504 14 sinusitis sinusitis NN cord-024189-t7mbsr25 504 15 , , , cord-024189-t7mbsr25 504 16 but but CC cord-024189-t7mbsr25 504 17 is be VBZ cord-024189-t7mbsr25 504 18 rarely rarely RB cord-024189-t7mbsr25 504 19 associated associate VBN cord-024189-t7mbsr25 504 20 with with IN cord-024189-t7mbsr25 504 21 destructive destructive JJ cord-024189-t7mbsr25 504 22 lesions lesion NNS cord-024189-t7mbsr25 504 23 . . . cord-024189-t7mbsr25 505 1 A a DT cord-024189-t7mbsr25 505 2 host host NN cord-024189-t7mbsr25 505 3 of of IN cord-024189-t7mbsr25 505 4 ocular ocular JJ cord-024189-t7mbsr25 505 5 lesions lesion NNS cord-024189-t7mbsr25 505 6 may may MD cord-024189-t7mbsr25 505 7 occur occur VB cord-024189-t7mbsr25 505 8 in in IN cord-024189-t7mbsr25 505 9 the the DT cord-024189-t7mbsr25 505 10 AAV AAV NNP cord-024189-t7mbsr25 505 11 , , , cord-024189-t7mbsr25 505 12 including include VBG cord-024189-t7mbsr25 505 13 episcleritis episcleritis NNP cord-024189-t7mbsr25 505 14 , , , cord-024189-t7mbsr25 505 15 scleritis scleritis NNP cord-024189-t7mbsr25 505 16 , , , cord-024189-t7mbsr25 505 17 peripheral peripheral JJ cord-024189-t7mbsr25 505 18 ulcerative ulcerative JJ cord-024189-t7mbsr25 505 19 keratitis keratitis NN cord-024189-t7mbsr25 505 20 , , , cord-024189-t7mbsr25 505 21 and and CC cord-024189-t7mbsr25 505 22 orbital orbital JJ cord-024189-t7mbsr25 505 23 pseudotumor pseudotumor NN cord-024189-t7mbsr25 505 24 . . . cord-024189-t7mbsr25 506 1 Lung lung NN cord-024189-t7mbsr25 506 2 disease disease NN cord-024189-t7mbsr25 506 3 is be VBZ cord-024189-t7mbsr25 506 4 common common JJ cord-024189-t7mbsr25 506 5 in in IN cord-024189-t7mbsr25 506 6 the the DT cord-024189-t7mbsr25 506 7 AAV AAV NNP cord-024189-t7mbsr25 506 8 and and CC cord-024189-t7mbsr25 506 9 ranges range VBZ cord-024189-t7mbsr25 506 10 from from IN cord-024189-t7mbsr25 506 11 asthma asthma NN cord-024189-t7mbsr25 506 12 ( ( -LRB- cord-024189-t7mbsr25 506 13 in in IN cord-024189-t7mbsr25 506 14 CSS CSS NNP cord-024189-t7mbsr25 506 15 ) ) -RRB- cord-024189-t7mbsr25 506 16 to to IN cord-024189-t7mbsr25 506 17 nodular nodular JJ cord-024189-t7mbsr25 506 18 lesions lesion NNS cord-024189-t7mbsr25 506 19 with with IN cord-024189-t7mbsr25 506 20 a a DT cord-024189-t7mbsr25 506 21 tendency tendency NN cord-024189-t7mbsr25 506 22 to to TO cord-024189-t7mbsr25 506 23 cavitate cavitate VB cord-024189-t7mbsr25 506 24 ( ( -LRB- cord-024189-t7mbsr25 506 25 in in IN cord-024189-t7mbsr25 506 26 WG WG NNP cord-024189-t7mbsr25 506 27 ) ) -RRB- cord-024189-t7mbsr25 506 28 to to IN cord-024189-t7mbsr25 506 29 interstitial interstitial JJ cord-024189-t7mbsr25 506 30 lung lung NN cord-024189-t7mbsr25 506 31 disease disease NN cord-024189-t7mbsr25 506 32 ( ( -LRB- cord-024189-t7mbsr25 506 33 MPA MPA NNP cord-024189-t7mbsr25 506 34 ) ) -RRB- cord-024189-t7mbsr25 506 35 to to IN cord-024189-t7mbsr25 506 36 alveolar alveolar JJ cord-024189-t7mbsr25 506 37 hemorrhage hemorrhage NN cord-024189-t7mbsr25 506 38 ( ( -LRB- cord-024189-t7mbsr25 506 39 all all DT cord-024189-t7mbsr25 506 40 forms form NNS cord-024189-t7mbsr25 506 41 of of IN cord-024189-t7mbsr25 506 42 AAV AAV NNP cord-024189-t7mbsr25 506 43 ) ) -RRB- cord-024189-t7mbsr25 506 44 . . . cord-024189-t7mbsr25 507 1 Segmental Segmental NNP cord-024189-t7mbsr25 507 2 , , , cord-024189-t7mbsr25 507 3 necrotizing necrotize VBG cord-024189-t7mbsr25 507 4 glomerulonephritis glomerulonephritis NN cord-024189-t7mbsr25 507 5 commonly commonly RB cord-024189-t7mbsr25 507 6 accompanies accompany VBZ cord-024189-t7mbsr25 507 7 the the DT cord-024189-t7mbsr25 507 8 AAV AAV NNP cord-024189-t7mbsr25 507 9 , , , cord-024189-t7mbsr25 507 10 particularly particularly RB cord-024189-t7mbsr25 507 11 WG WG NNP cord-024189-t7mbsr25 507 12 and and CC cord-024189-t7mbsr25 507 13 MPA MPA NNP cord-024189-t7mbsr25 507 14 . . . cord-024189-t7mbsr25 508 1 Eosinophilia Eosinophilia NNP cord-024189-t7mbsr25 508 2 is be VBZ cord-024189-t7mbsr25 508 3 the the DT cord-024189-t7mbsr25 508 4 sine sine FW cord-024189-t7mbsr25 508 5 qua qua FW cord-024189-t7mbsr25 508 6 non non FW cord-024189-t7mbsr25 508 7 of of IN cord-024189-t7mbsr25 508 8 CSS CSS NNP cord-024189-t7mbsr25 508 9 . . . cord-024189-t7mbsr25 509 1 In in IN cord-024189-t7mbsr25 509 2 1954 1954 CD cord-024189-t7mbsr25 509 3 , , , cord-024189-t7mbsr25 509 4 Godman Godman NNP cord-024189-t7mbsr25 509 5 and and CC cord-024189-t7mbsr25 509 6 Churg Churg NNP cord-024189-t7mbsr25 509 7 observed observe VBD cord-024189-t7mbsr25 509 8 that that IN cord-024189-t7mbsr25 509 9 Wegener Wegener NNP cord-024189-t7mbsr25 509 10 's 's POS cord-024189-t7mbsr25 509 11 granulomatosis granulomatosis NN cord-024189-t7mbsr25 509 12 ( ( -LRB- cord-024189-t7mbsr25 509 13 WG WG NNP cord-024189-t7mbsr25 509 14 ) ) -RRB- cord-024189-t7mbsr25 509 15 , , , cord-024189-t7mbsr25 509 16 microscopic microscopic JJ cord-024189-t7mbsr25 509 17 polyangiitis polyangiitis NN cord-024189-t7mbsr25 509 18 ( ( -LRB- cord-024189-t7mbsr25 509 19 MPA MPA NNP cord-024189-t7mbsr25 509 20 ) ) -RRB- cord-024189-t7mbsr25 509 21 , , , cord-024189-t7mbsr25 509 22 and and CC cord-024189-t7mbsr25 509 23 the the DT cord-024189-t7mbsr25 509 24 Churg Churg NNP cord-024189-t7mbsr25 509 25 - - HYPH cord-024189-t7mbsr25 509 26 Strauss Strauss NNP cord-024189-t7mbsr25 509 27 syndrome syndrome NN cord-024189-t7mbsr25 509 28 ( ( -LRB- cord-024189-t7mbsr25 509 29 CSS css NN cord-024189-t7mbsr25 509 30 ) ) -RRB- cord-024189-t7mbsr25 509 31 share share VBP cord-024189-t7mbsr25 509 32 certain certain JJ cord-024189-t7mbsr25 509 33 pathological pathological JJ cord-024189-t7mbsr25 509 34 similarities similarity NNS cord-024189-t7mbsr25 509 35 despite despite IN cord-024189-t7mbsr25 509 36 their -PRON- PRP$ cord-024189-t7mbsr25 509 37 clinical clinical JJ cord-024189-t7mbsr25 509 38 distinctions distinction NNS cord-024189-t7mbsr25 509 39 ( ( -LRB- cord-024189-t7mbsr25 509 40 1 1 CD cord-024189-t7mbsr25 509 41 ) ) -RRB- cord-024189-t7mbsr25 509 42 . . . cord-024189-t7mbsr25 510 1 These these DT cord-024189-t7mbsr25 510 2 diseases disease NNS cord-024189-t7mbsr25 510 3 , , , cord-024189-t7mbsr25 510 4 Godman Godman NNP cord-024189-t7mbsr25 510 5 and and CC cord-024189-t7mbsr25 510 6 Churg Churg NNP cord-024189-t7mbsr25 510 7 noted note VBD cord-024189-t7mbsr25 510 8 , , , cord-024189-t7mbsr25 510 9 " " `` cord-024189-t7mbsr25 510 10 group group NN cord-024189-t7mbsr25 510 11 themselves -PRON- PRP cord-024189-t7mbsr25 510 12 into into IN cord-024189-t7mbsr25 510 13 a a DT cord-024189-t7mbsr25 510 14 compass compass NN cord-024189-t7mbsr25 510 15 , , , cord-024189-t7mbsr25 510 16 ( ( -LRB- cord-024189-t7mbsr25 510 17 ranging range VBG cord-024189-t7mbsr25 510 18 from from IN cord-024189-t7mbsr25 510 19 ) ) -RRB- cord-024189-t7mbsr25 510 20 necrotizing necrotize VBG cord-024189-t7mbsr25 510 21 and and CC cord-024189-t7mbsr25 510 22 granulomatous granulomatous JJ cord-024189-t7mbsr25 510 23 processes process NNS cord-024189-t7mbsr25 510 24 with with IN cord-024189-t7mbsr25 510 25 angiitis angiitis NN cord-024189-t7mbsr25 510 26 . . . cord-024189-t7mbsr25 511 1 . . . cord-024189-t7mbsr25 511 2 . . . cord-024189-t7mbsr25 512 1 to to IN cord-024189-t7mbsr25 512 2 vasculitis vasculitis NN cord-024189-t7mbsr25 512 3 without without IN cord-024189-t7mbsr25 512 4 granulomata granulomata NNP cord-024189-t7mbsr25 512 5 . . . cord-024189-t7mbsr25 513 1 " " `` cord-024189-t7mbsr25 513 2 Validation validation NN cord-024189-t7mbsr25 513 3 of of IN cord-024189-t7mbsr25 513 4 the the DT cord-024189-t7mbsr25 513 5 pathological pathological JJ cord-024189-t7mbsr25 513 6 links link NNS cord-024189-t7mbsr25 513 7 between between IN cord-024189-t7mbsr25 513 8 these these DT cord-024189-t7mbsr25 513 9 disorders disorder NNS cord-024189-t7mbsr25 513 10 became become VBD cord-024189-t7mbsr25 513 11 clear clear JJ cord-024189-t7mbsr25 513 12 three three CD cord-024189-t7mbsr25 513 13 decades decade NNS cord-024189-t7mbsr25 513 14 later later RB cord-024189-t7mbsr25 513 15 with with IN cord-024189-t7mbsr25 513 16 the the DT cord-024189-t7mbsr25 513 17 discovery discovery NN cord-024189-t7mbsr25 513 18 of of IN cord-024189-t7mbsr25 513 19 antineutrophil antineutrophil NNP cord-024189-t7mbsr25 513 20 cytoplasmic cytoplasmic JJ cord-024189-t7mbsr25 513 21 antibodies antibody NNS cord-024189-t7mbsr25 513 22 ( ( -LRB- cord-024189-t7mbsr25 513 23 ANCA ANCA NNP cord-024189-t7mbsr25 513 24 ) ) -RRB- cord-024189-t7mbsr25 513 25 and and CC cord-024189-t7mbsr25 513 26 the the DT cord-024189-t7mbsr25 513 27 fi fi XX cord-024189-t7mbsr25 513 28 nding nding NN cord-024189-t7mbsr25 513 29 that that IN cord-024189-t7mbsr25 513 30 most most JJS cord-024189-t7mbsr25 513 31 patients patient NNS cord-024189-t7mbsr25 513 32 with with IN cord-024189-t7mbsr25 513 33 WG WG NNP cord-024189-t7mbsr25 513 34 , , , cord-024189-t7mbsr25 513 35 MPA MPA NNP cord-024189-t7mbsr25 513 36 , , , cord-024189-t7mbsr25 513 37 and and CC cord-024189-t7mbsr25 513 38 ( ( -LRB- cord-024189-t7mbsr25 513 39 to to IN cord-024189-t7mbsr25 513 40 a a DT cord-024189-t7mbsr25 513 41 lesser less JJR cord-024189-t7mbsr25 513 42 extent extent NN cord-024189-t7mbsr25 513 43 ) ) -RRB- cord-024189-t7mbsr25 513 44 CSS css NN cord-024189-t7mbsr25 513 45 have have VBP cord-024189-t7mbsr25 513 46 ANCA ANCA NNP cord-024189-t7mbsr25 513 47 in in IN cord-024189-t7mbsr25 513 48 their -PRON- PRP$ cord-024189-t7mbsr25 513 49 serum serum NN cord-024189-t7mbsr25 513 50 . . . cord-024189-t7mbsr25 514 1 These these DT cord-024189-t7mbsr25 514 2 diseases disease NNS cord-024189-t7mbsr25 514 3 are be VBP cord-024189-t7mbsr25 514 4 commonly commonly RB cord-024189-t7mbsr25 514 5 termed term VBN cord-024189-t7mbsr25 514 6 ANCA ANCA NNP cord-024189-t7mbsr25 514 7 - - HYPH cord-024189-t7mbsr25 514 8 associated associate VBN cord-024189-t7mbsr25 514 9 vasculitides vasculitide NNS cord-024189-t7mbsr25 514 10 ( ( -LRB- cord-024189-t7mbsr25 514 11 AAV AAV NNP cord-024189-t7mbsr25 514 12 ) ) -RRB- cord-024189-t7mbsr25 514 13 , , , cord-024189-t7mbsr25 514 14 even even RB cord-024189-t7mbsr25 514 15 though though IN cord-024189-t7mbsr25 514 16 not not RB cord-024189-t7mbsr25 514 17 all all DT cord-024189-t7mbsr25 514 18 patients patient NNS cord-024189-t7mbsr25 514 19 with with IN cord-024189-t7mbsr25 514 20 these these DT cord-024189-t7mbsr25 514 21 diseases disease NNS cord-024189-t7mbsr25 514 22 have have VBP cord-024189-t7mbsr25 514 23 detectable detectable JJ cord-024189-t7mbsr25 514 24 ANCA ANCA NNP cord-024189-t7mbsr25 514 25 ( ( -LRB- cord-024189-t7mbsr25 514 26 Table table NN cord-024189-t7mbsr25 514 27 21C-1 21c-1 CD cord-024189-t7mbsr25 514 28 ) ) -RRB- cord-024189-t7mbsr25 514 29 . . . cord-024189-t7mbsr25 515 1 Anticytoplasmic Anticytoplasmic NNP cord-024189-t7mbsr25 515 2 antibodies antibody NNS cord-024189-t7mbsr25 515 3 directed direct VBN cord-024189-t7mbsr25 515 4 against against IN cord-024189-t7mbsr25 515 5 neutrophils neutrophil NNS cord-024189-t7mbsr25 515 6 ( ( -LRB- cord-024189-t7mbsr25 515 7 i.e. i.e. FW cord-024189-t7mbsr25 515 8 , , , cord-024189-t7mbsr25 515 9 ANCA ANCA NNP cord-024189-t7mbsr25 515 10 ) ) -RRB- cord-024189-t7mbsr25 515 11 were be VBD cord-024189-t7mbsr25 515 12 reported report VBN cord-024189-t7mbsr25 515 13 in in IN cord-024189-t7mbsr25 515 14 association association NN cord-024189-t7mbsr25 515 15 with with IN cord-024189-t7mbsr25 515 16 segmental segmental JJ cord-024189-t7mbsr25 515 17 necrotizing necrotize VBG cord-024189-t7mbsr25 515 18 glomerulonephritis glomerulonephritis NN cord-024189-t7mbsr25 515 19 in in IN cord-024189-t7mbsr25 515 20 the the DT cord-024189-t7mbsr25 515 21 early early JJ cord-024189-t7mbsr25 515 22 1980s 1980s CD cord-024189-t7mbsr25 515 23 . . . cord-024189-t7mbsr25 516 1 In in IN cord-024189-t7mbsr25 516 2 1985 1985 CD cord-024189-t7mbsr25 516 3 , , , cord-024189-t7mbsr25 516 4 the the DT cord-024189-t7mbsr25 516 5 presence presence NN cord-024189-t7mbsr25 516 6 of of IN cord-024189-t7mbsr25 516 7 diffuse diffuse JJ cord-024189-t7mbsr25 516 8 cytoplasmic cytoplasmic JJ cord-024189-t7mbsr25 516 9 staining staining NN cord-024189-t7mbsr25 516 10 of of IN cord-024189-t7mbsr25 516 11 neutrophils neutrophil NNS cord-024189-t7mbsr25 516 12 was be VBD cord-024189-t7mbsr25 516 13 reported report VBN cord-024189-t7mbsr25 516 14 in in IN cord-024189-t7mbsr25 516 15 patients patient NNS cord-024189-t7mbsr25 516 16 with with IN cord-024189-t7mbsr25 516 17 WG WG NNP cord-024189-t7mbsr25 516 18 ( ( -LRB- cord-024189-t7mbsr25 516 19 2 2 CD cord-024189-t7mbsr25 516 20 ) ) -RRB- cord-024189-t7mbsr25 516 21 . . . cord-024189-t7mbsr25 517 1 In in IN cord-024189-t7mbsr25 517 2 studies study NNS cord-024189-t7mbsr25 517 3 of of IN cord-024189-t7mbsr25 517 4 patients patient NNS cord-024189-t7mbsr25 517 5 with with IN cord-024189-t7mbsr25 517 6 WG WG NNP cord-024189-t7mbsr25 517 7 , , , cord-024189-t7mbsr25 517 8 MPA MPA NNP cord-024189-t7mbsr25 517 9 , , , cord-024189-t7mbsr25 517 10 or or CC cord-024189-t7mbsr25 517 11 renal renal JJ cord-024189-t7mbsr25 517 12 - - HYPH cord-024189-t7mbsr25 517 13 limited limited JJ cord-024189-t7mbsr25 517 14 vasculitis vasculitis NN cord-024189-t7mbsr25 517 15 , , , cord-024189-t7mbsr25 517 16 Falk Falk NNP cord-024189-t7mbsr25 517 17 and and CC cord-024189-t7mbsr25 517 18 Jennette Jennette NNP cord-024189-t7mbsr25 517 19 ( ( -LRB- cord-024189-t7mbsr25 517 20 3 3 CD cord-024189-t7mbsr25 517 21 ) ) -RRB- cord-024189-t7mbsr25 517 22 noted note VBD cord-024189-t7mbsr25 517 23 another another DT cord-024189-t7mbsr25 517 24 pattern pattern NN cord-024189-t7mbsr25 517 25 of of IN cord-024189-t7mbsr25 517 26 immunostaining immunostaine VBG cord-024189-t7mbsr25 517 27 - - HYPH cord-024189-t7mbsr25 517 28 perinuclear perinuclear NNP cord-024189-t7mbsr25 517 29 fl fl NNP cord-024189-t7mbsr25 517 30 uorescence uorescence NN cord-024189-t7mbsr25 517 31 of of IN cord-024189-t7mbsr25 517 32 alcohol alcohol NN cord-024189-t7mbsr25 517 33 - - HYPH cord-024189-t7mbsr25 517 34 fi fi NN cord-024189-t7mbsr25 517 35 xed xed JJ cord-024189-t7mbsr25 517 36 neutrophils neutrophil NNS cord-024189-t7mbsr25 517 37 . . . cord-024189-t7mbsr25 518 1 The the DT cord-024189-t7mbsr25 518 2 two two CD cord-024189-t7mbsr25 518 3 types type NNS cord-024189-t7mbsr25 518 4 of of IN cord-024189-t7mbsr25 518 5 antibodies antibody NNS cord-024189-t7mbsr25 518 6 associated associate VBN cord-024189-t7mbsr25 518 7 with with IN cord-024189-t7mbsr25 518 8 AAV AAV NNP cord-024189-t7mbsr25 518 9 are be VBP cord-024189-t7mbsr25 518 10 those those DT cord-024189-t7mbsr25 518 11 directed direct VBN cord-024189-t7mbsr25 518 12 against against IN cord-024189-t7mbsr25 518 13 ( ( -LRB- cord-024189-t7mbsr25 518 14 1 1 CD cord-024189-t7mbsr25 518 15 ) ) -RRB- cord-024189-t7mbsr25 518 16 proteinase-3 proteinase-3 NNP cord-024189-t7mbsr25 518 17 ( ( -LRB- cord-024189-t7mbsr25 518 18 PR3 PR3 NNP cord-024189-t7mbsr25 518 19 ) ) -RRB- cord-024189-t7mbsr25 518 20 and and CC cord-024189-t7mbsr25 518 21 ( ( -LRB- cord-024189-t7mbsr25 518 22 2 2 LS cord-024189-t7mbsr25 518 23 ) ) -RRB- cord-024189-t7mbsr25 518 24 myeloperoxidase myeloperoxidase NNP cord-024189-t7mbsr25 518 25 ( ( -LRB- cord-024189-t7mbsr25 518 26 MPO MPO NNP cord-024189-t7mbsr25 518 27 ) ) -RRB- cord-024189-t7mbsr25 518 28 . . . cord-024189-t7mbsr25 519 1 PR3 PR3 NNP cord-024189-t7mbsr25 519 2 and and CC cord-024189-t7mbsr25 519 3 MPO MPO NNP cord-024189-t7mbsr25 519 4 , , , cord-024189-t7mbsr25 519 5 both both DT cord-024189-t7mbsr25 519 6 serine serine NN cord-024189-t7mbsr25 519 7 proteases protease NNS cord-024189-t7mbsr25 519 8 , , , cord-024189-t7mbsr25 519 9 are be VBP cord-024189-t7mbsr25 519 10 constituents constituent NNS cord-024189-t7mbsr25 519 11 of of IN cord-024189-t7mbsr25 519 12 the the DT cord-024189-t7mbsr25 519 13 primary primary JJ cord-024189-t7mbsr25 519 14 granules granule NNS cord-024189-t7mbsr25 519 15 of of IN cord-024189-t7mbsr25 519 16 neutrophils neutrophil NNS cord-024189-t7mbsr25 519 17 and and CC cord-024189-t7mbsr25 519 18 monocytes monocyte NNS cord-024189-t7mbsr25 519 19 . . . cord-024189-t7mbsr25 520 1 Antibodies antibody NNS cord-024189-t7mbsr25 520 2 directed direct VBN cord-024189-t7mbsr25 520 3 against against IN cord-024189-t7mbsr25 520 4 these these DT cord-024189-t7mbsr25 520 5 antigens antigen NNS cord-024189-t7mbsr25 520 6 are be VBP cord-024189-t7mbsr25 520 7 known know VBN cord-024189-t7mbsr25 520 8 , , , cord-024189-t7mbsr25 520 9 respectively respectively RB cord-024189-t7mbsr25 520 10 , , , cord-024189-t7mbsr25 520 11 as as IN cord-024189-t7mbsr25 520 12 PR3-ANCA PR3-ANCA NNP cord-024189-t7mbsr25 520 13 and and CC cord-024189-t7mbsr25 520 14 MPO MPO NNP cord-024189-t7mbsr25 520 15 - - HYPH cord-024189-t7mbsr25 520 16 ANCA ANCA NNP cord-024189-t7mbsr25 520 17 . . . cord-024189-t7mbsr25 521 1 The the DT cord-024189-t7mbsr25 521 2 1990 1990 CD cord-024189-t7mbsr25 521 3 American American NNP cord-024189-t7mbsr25 521 4 College College NNP cord-024189-t7mbsr25 521 5 of of IN cord-024189-t7mbsr25 521 6 Rheumatology Rheumatology NNP cord-024189-t7mbsr25 521 7 classification classification NN cord-024189-t7mbsr25 521 8 criteria criterion NNS cord-024189-t7mbsr25 521 9 for for IN cord-024189-t7mbsr25 521 10 WG WG NNP cord-024189-t7mbsr25 521 11 and and CC cord-024189-t7mbsr25 521 12 the the DT cord-024189-t7mbsr25 521 13 CSS css NN cord-024189-t7mbsr25 521 14 ( ( -LRB- cord-024189-t7mbsr25 521 15 Table table NN cord-024189-t7mbsr25 521 16 21C-1 21c-1 CD cord-024189-t7mbsr25 521 17 ) ) -RRB- cord-024189-t7mbsr25 521 18 ( ( -LRB- cord-024189-t7mbsr25 521 19 4 4 CD cord-024189-t7mbsr25 521 20 , , , cord-024189-t7mbsr25 521 21 5 5 CD cord-024189-t7mbsr25 521 22 ) ) -RRB- cord-024189-t7mbsr25 521 23 were be VBD cord-024189-t7mbsr25 521 24 developed develop VBN cord-024189-t7mbsr25 521 25 to to TO cord-024189-t7mbsr25 521 26 ensure ensure VB cord-024189-t7mbsr25 521 27 the the DT cord-024189-t7mbsr25 521 28 inclusion inclusion NN cord-024189-t7mbsr25 521 29 of of IN cord-024189-t7mbsr25 521 30 uniform uniform JJ cord-024189-t7mbsr25 521 31 disease disease NN cord-024189-t7mbsr25 521 32 populations population NNS cord-024189-t7mbsr25 521 33 in in IN cord-024189-t7mbsr25 521 34 research research NN cord-024189-t7mbsr25 521 35 studies study NNS cord-024189-t7mbsr25 521 36 ( ( -LRB- cord-024189-t7mbsr25 521 37 6 6 CD cord-024189-t7mbsr25 521 38 ) ) -RRB- cord-024189-t7mbsr25 521 39 . . . cord-024189-t7mbsr25 522 1 These these DT cord-024189-t7mbsr25 522 2 criteria criterion NNS cord-024189-t7mbsr25 522 3 did do VBD cord-024189-t7mbsr25 522 4 not not RB cord-024189-t7mbsr25 522 5 address address VB cord-024189-t7mbsr25 522 6 the the DT cord-024189-t7mbsr25 522 7 utility utility NN cord-024189-t7mbsr25 522 8 of of IN cord-024189-t7mbsr25 522 9 ANCA ANCA NNP cord-024189-t7mbsr25 522 10 for for IN cord-024189-t7mbsr25 522 11 classifi classifi NNP cord-024189-t7mbsr25 522 12 cation cation NNP cord-024189-t7mbsr25 522 13 or or CC cord-024189-t7mbsr25 522 14 the the DT cord-024189-t7mbsr25 522 15 difference difference NN cord-024189-t7mbsr25 522 16 between between IN cord-024189-t7mbsr25 522 17 polyarteritis polyarteritis NN cord-024189-t7mbsr25 522 18 nodosa nodosa NNP cord-024189-t7mbsr25 522 19 and and CC cord-024189-t7mbsr25 522 20 MPA MPA NNP cord-024189-t7mbsr25 522 21 . . . cord-024189-t7mbsr25 523 1 These these DT cord-024189-t7mbsr25 523 2 limitations limitation NNS cord-024189-t7mbsr25 523 3 were be VBD cord-024189-t7mbsr25 523 4 addressed address VBN cord-024189-t7mbsr25 523 5 by by IN cord-024189-t7mbsr25 523 6 the the DT cord-024189-t7mbsr25 523 7 Chapel Chapel NNP cord-024189-t7mbsr25 523 8 Hill Hill NNP cord-024189-t7mbsr25 523 9 Consensus Consensus NNP cord-024189-t7mbsr25 523 10 Conference Conference NNP cord-024189-t7mbsr25 523 11 ( ( -LRB- cord-024189-t7mbsr25 523 12 Table Table NNP cord-024189-t7mbsr25 523 13 21C 21C NNP cord-024189-t7mbsr25 523 14 -2 -2 CD cord-024189-t7mbsr25 523 15 ) ) -RRB- cord-024189-t7mbsr25 523 16 ( ( -LRB- cord-024189-t7mbsr25 523 17 7 7 CD cord-024189-t7mbsr25 523 18 ) ) -RRB- cord-024189-t7mbsr25 523 19 . . . cord-024189-t7mbsr25 524 1 To to IN cord-024189-t7mbsr25 524 2 date date NN cord-024189-t7mbsr25 524 3 , , , cord-024189-t7mbsr25 524 4 widely widely RB cord-024189-t7mbsr25 524 5 accepted accept VBN cord-024189-t7mbsr25 524 6 diagnostic diagnostic JJ cord-024189-t7mbsr25 524 7 criteria criterion NNS cord-024189-t7mbsr25 524 8 for for IN cord-024189-t7mbsr25 524 9 these these DT cord-024189-t7mbsr25 524 10 diseases disease NNS cord-024189-t7mbsr25 524 11 have have VBP cord-024189-t7mbsr25 524 12 not not RB cord-024189-t7mbsr25 524 13 been be VBN cord-024189-t7mbsr25 524 14 developed develop VBN cord-024189-t7mbsr25 524 15 . . . cord-024189-t7mbsr25 525 1 A a DT cord-024189-t7mbsr25 525 2 population population NN cord-024189-t7mbsr25 525 3 - - HYPH cord-024189-t7mbsr25 525 4 based base VBN cord-024189-t7mbsr25 525 5 study study NN cord-024189-t7mbsr25 525 6 from from IN cord-024189-t7mbsr25 525 7 Norfolk Norfolk NNP cord-024189-t7mbsr25 525 8 , , , cord-024189-t7mbsr25 525 9 England England NNP cord-024189-t7mbsr25 525 10 , , , cord-024189-t7mbsr25 525 11 reported report VBD cord-024189-t7mbsr25 525 12 incidences incidence NNS cord-024189-t7mbsr25 525 13 of of IN cord-024189-t7mbsr25 525 14 8.5 8.5 CD cord-024189-t7mbsr25 525 15 cases case NNS cord-024189-t7mbsr25 525 16 per per IN cord-024189-t7mbsr25 525 17 million million CD cord-024189-t7mbsr25 525 18 for for IN cord-024189-t7mbsr25 525 19 WG WG NNP cord-024189-t7mbsr25 525 20 , , , cord-024189-t7mbsr25 525 21 3.6 3.6 CD cord-024189-t7mbsr25 525 22 cases case NNS cord-024189-t7mbsr25 525 23 per per IN cord-024189-t7mbsr25 525 24 million million CD cord-024189-t7mbsr25 525 25 for for IN cord-024189-t7mbsr25 525 26 MPA MPA NNP cord-024189-t7mbsr25 525 27 , , , cord-024189-t7mbsr25 525 28 and and CC cord-024189-t7mbsr25 525 29 2.4 2.4 CD cord-024189-t7mbsr25 525 30 cases case NNS cord-024189-t7mbsr25 525 31 per per IN cord-024189-t7mbsr25 525 32 million million CD cord-024189-t7mbsr25 525 33 for for IN cord-024189-t7mbsr25 525 34 the the DT cord-024189-t7mbsr25 525 35 CSS css NN cord-024189-t7mbsr25 525 36 ( ( -LRB- cord-024189-t7mbsr25 525 37 8) 8) NN cord-024189-t7mbsr25 525 38 . . . cord-024189-t7mbsr25 526 1 In in IN cord-024189-t7mbsr25 526 2 two two CD cord-024189-t7mbsr25 526 3 large large JJ cord-024189-t7mbsr25 526 4 U.S. U.S. NNP cord-024189-t7mbsr25 526 5 cohorts cohort NNS cord-024189-t7mbsr25 526 6 of of IN cord-024189-t7mbsr25 526 7 patients patient NNS cord-024189-t7mbsr25 526 8 with with IN cord-024189-t7mbsr25 526 9 WG WG NNP cord-024189-t7mbsr25 526 10 ( ( -LRB- cord-024189-t7mbsr25 526 11 9,10 9,10 CD cord-024189-t7mbsr25 526 12 ) ) -RRB- cord-024189-t7mbsr25 526 13 , , , cord-024189-t7mbsr25 526 14 whites white NNS cord-024189-t7mbsr25 526 15 comprised comprise VBD cord-024189-t7mbsr25 526 16 more more JJR cord-024189-t7mbsr25 526 17 than than IN cord-024189-t7mbsr25 526 18 90 90 CD cord-024189-t7mbsr25 526 19 % % NN cord-024189-t7mbsr25 526 20 of of IN cord-024189-t7mbsr25 526 21 all all DT cord-024189-t7mbsr25 526 22 cases case NNS cord-024189-t7mbsr25 526 23 , , , cord-024189-t7mbsr25 526 24 whereas whereas IN cord-024189-t7mbsr25 526 25 African African NNP cord-024189-t7mbsr25 526 26 Americans Americans NNPS cord-024189-t7mbsr25 526 27 , , , cord-024189-t7mbsr25 526 28 Hispanics Hispanics NNPS cord-024189-t7mbsr25 526 29 , , , cord-024189-t7mbsr25 526 30 and and CC cord-024189-t7mbsr25 526 31 Asians Asians NNPS cord-024189-t7mbsr25 526 32 together together RB cord-024189-t7mbsr25 526 33 represented represent VBD cord-024189-t7mbsr25 526 34 1 1 CD cord-024189-t7mbsr25 526 35 % % NN cord-024189-t7mbsr25 526 36 to to IN cord-024189-t7mbsr25 526 37 4 4 CD cord-024189-t7mbsr25 526 38 % % NN cord-024189-t7mbsr25 526 39 of of IN cord-024189-t7mbsr25 526 40 cases case NNS cord-024189-t7mbsr25 526 41 . . . cord-024189-t7mbsr25 527 1 The the DT cord-024189-t7mbsr25 527 2 mean mean JJ cord-024189-t7mbsr25 527 3 age age NN cord-024189-t7mbsr25 527 4 at at IN cord-024189-t7mbsr25 527 5 diagnosis diagnosis NN cord-024189-t7mbsr25 527 6 is be VBZ cord-024189-t7mbsr25 527 7 about about RB cord-024189-t7mbsr25 527 8 55 55 CD cord-024189-t7mbsr25 527 9 years year NNS cord-024189-t7mbsr25 527 10 , , , cord-024189-t7mbsr25 527 11 but but CC cord-024189-t7mbsr25 527 12 cases case NNS cord-024189-t7mbsr25 527 13 involving involve VBG cord-024189-t7mbsr25 527 14 octogenarians octogenarian NNS cord-024189-t7mbsr25 527 15 are be VBP cord-024189-t7mbsr25 527 16 not not RB cord-024189-t7mbsr25 527 17 unusual unusual JJ cord-024189-t7mbsr25 527 18 . . . cord-024189-t7mbsr25 528 1 Wegener Wegener NNP cord-024189-t7mbsr25 528 2 's 's POS cord-024189-t7mbsr25 528 3 granulomatosis granulomatosis NN cord-024189-t7mbsr25 528 4 Granulomatous granulomatous JJ cord-024189-t7mbsr25 528 5 infl infl NN cord-024189-t7mbsr25 528 6 ammation ammation NN cord-024189-t7mbsr25 528 7 involving involve VBG cord-024189-t7mbsr25 528 8 the the DT cord-024189-t7mbsr25 528 9 respiratory respiratory JJ cord-024189-t7mbsr25 528 10 tract tract NN cord-024189-t7mbsr25 528 11 , , , cord-024189-t7mbsr25 528 12 and and CC cord-024189-t7mbsr25 528 13 necrotizing necrotize VBG cord-024189-t7mbsr25 528 14 vasculitis vasculitis NN cord-024189-t7mbsr25 528 15 affecting affect VBG cord-024189-t7mbsr25 528 16 small small JJ cord-024189-t7mbsr25 528 17 - - HYPH cord-024189-t7mbsr25 528 18 to to TO cord-024189-t7mbsr25 528 19 medium medium JJ cord-024189-t7mbsr25 528 20 - - HYPH cord-024189-t7mbsr25 528 21 sized sized JJ cord-024189-t7mbsr25 528 22 vessels vessel NNS cord-024189-t7mbsr25 528 23 ( ( -LRB- cord-024189-t7mbsr25 528 24 e.g. e.g. RB cord-024189-t7mbsr25 528 25 , , , cord-024189-t7mbsr25 528 26 capillaries capillary NNS cord-024189-t7mbsr25 528 27 , , , cord-024189-t7mbsr25 528 28 venules venule NNS cord-024189-t7mbsr25 528 29 , , , cord-024189-t7mbsr25 528 30 arterioles arteriole NNS cord-024189-t7mbsr25 528 31 , , , cord-024189-t7mbsr25 528 32 and and CC cord-024189-t7mbsr25 528 33 arteries artery NNS cord-024189-t7mbsr25 528 34 ) ) -RRB- cord-024189-t7mbsr25 528 35 . . . cord-024189-t7mbsr25 529 1 Necrotizing necrotize VBG cord-024189-t7mbsr25 529 2 glomerulonephritis glomerulonephritis NN cord-024189-t7mbsr25 529 3 is be VBZ cord-024189-t7mbsr25 529 4 common common JJ cord-024189-t7mbsr25 529 5 . . . cord-024189-t7mbsr25 530 1 Microscopic microscopic JJ cord-024189-t7mbsr25 530 2 polyangiitis polyangiitis NN cord-024189-t7mbsr25 530 3 Necrotizing necrotize VBG cord-024189-t7mbsr25 530 4 vasculitis vasculitis NN cord-024189-t7mbsr25 530 5 , , , cord-024189-t7mbsr25 530 6 with with IN cord-024189-t7mbsr25 530 7 few few JJ cord-024189-t7mbsr25 530 8 or or CC cord-024189-t7mbsr25 530 9 no no DT cord-024189-t7mbsr25 530 10 immune immune JJ cord-024189-t7mbsr25 530 11 deposits deposit NNS cord-024189-t7mbsr25 530 12 , , , cord-024189-t7mbsr25 530 13 affecting affect VBG cord-024189-t7mbsr25 530 14 small small JJ cord-024189-t7mbsr25 530 15 vessels vessel NNS cord-024189-t7mbsr25 530 16 ( ( -LRB- cord-024189-t7mbsr25 530 17 i.e. i.e. FW cord-024189-t7mbsr25 530 18 , , , cord-024189-t7mbsr25 530 19 capillaries capillary NNS cord-024189-t7mbsr25 530 20 , , , cord-024189-t7mbsr25 530 21 venules venule NNS cord-024189-t7mbsr25 530 22 , , , cord-024189-t7mbsr25 530 23 or or CC cord-024189-t7mbsr25 530 24 arterioles arteriole NNS cord-024189-t7mbsr25 530 25 ) ) -RRB- cord-024189-t7mbsr25 530 26 . . . cord-024189-t7mbsr25 531 1 Necrotizing necrotize VBG cord-024189-t7mbsr25 531 2 arteritis arteritis NN cord-024189-t7mbsr25 531 3 involving involve VBG cord-024189-t7mbsr25 531 4 small small JJ cord-024189-t7mbsr25 531 5 - - HYPH cord-024189-t7mbsr25 531 6 and and CC cord-024189-t7mbsr25 531 7 medium medium JJ cord-024189-t7mbsr25 531 8 - - HYPH cord-024189-t7mbsr25 531 9 sized sized JJ cord-024189-t7mbsr25 531 10 arteries artery NNS cord-024189-t7mbsr25 531 11 may may MD cord-024189-t7mbsr25 531 12 be be VB cord-024189-t7mbsr25 531 13 present present JJ cord-024189-t7mbsr25 531 14 . . . cord-024189-t7mbsr25 532 1 Necrotizing necrotize VBG cord-024189-t7mbsr25 532 2 glomerulonephritis glomerulonephritis NN cord-024189-t7mbsr25 532 3 is be VBZ cord-024189-t7mbsr25 532 4 very very RB cord-024189-t7mbsr25 532 5 common common JJ cord-024189-t7mbsr25 532 6 . . . cord-024189-t7mbsr25 533 1 Pulmonary pulmonary JJ cord-024189-t7mbsr25 533 2 capillaritis capillaritis NN cord-024189-t7mbsr25 533 3 often often RB cord-024189-t7mbsr25 533 4 occurs occur VBZ cord-024189-t7mbsr25 533 5 . . . cord-024189-t7mbsr25 534 1 Churg Churg NNP cord-024189-t7mbsr25 534 2 - - HYPH cord-024189-t7mbsr25 534 3 Strauss Strauss NNP cord-024189-t7mbsr25 534 4 syndrome syndrome NN cord-024189-t7mbsr25 534 5 Eosinophil eosinophil JJ cord-024189-t7mbsr25 534 6 - - HYPH cord-024189-t7mbsr25 534 7 rich rich JJ cord-024189-t7mbsr25 534 8 and and CC cord-024189-t7mbsr25 534 9 granulomatous granulomatous JJ cord-024189-t7mbsr25 534 10 infl infl NN cord-024189-t7mbsr25 534 11 ammation ammation NN cord-024189-t7mbsr25 534 12 involving involve VBG cord-024189-t7mbsr25 534 13 the the DT cord-024189-t7mbsr25 534 14 respiratory respiratory JJ cord-024189-t7mbsr25 534 15 tract tract NN cord-024189-t7mbsr25 534 16 , , , cord-024189-t7mbsr25 534 17 and and CC cord-024189-t7mbsr25 534 18 necrotizing necrotize VBG cord-024189-t7mbsr25 534 19 vasculitis vasculitis NN cord-024189-t7mbsr25 534 20 affecting affect VBG cord-024189-t7mbsr25 534 21 small small JJ cord-024189-t7mbsr25 534 22 - - HYPH cord-024189-t7mbsr25 534 23 to to TO cord-024189-t7mbsr25 534 24 medium medium JJ cord-024189-t7mbsr25 534 25 - - HYPH cord-024189-t7mbsr25 534 26 sized sized JJ cord-024189-t7mbsr25 534 27 vessels vessel NNS cord-024189-t7mbsr25 534 28 , , , cord-024189-t7mbsr25 534 29 associated associate VBN cord-024189-t7mbsr25 534 30 with with IN cord-024189-t7mbsr25 534 31 asthma asthma NN cord-024189-t7mbsr25 534 32 and and CC cord-024189-t7mbsr25 534 33 eosinophilia eosinophilia NN cord-024189-t7mbsr25 534 34 . . . cord-024189-t7mbsr25 534 35 _SP cord-024189-t7mbsr25 535 1 There there EX cord-024189-t7mbsr25 535 2 is be VBZ cord-024189-t7mbsr25 535 3 substantial substantial JJ cord-024189-t7mbsr25 535 4 overlap overlap NN cord-024189-t7mbsr25 535 5 in in IN cord-024189-t7mbsr25 535 6 many many JJ cord-024189-t7mbsr25 535 7 of of IN cord-024189-t7mbsr25 535 8 the the DT cord-024189-t7mbsr25 535 9 clinical clinical JJ cord-024189-t7mbsr25 535 10 features feature NNS cord-024189-t7mbsr25 535 11 of of IN cord-024189-t7mbsr25 535 12 the the DT cord-024189-t7mbsr25 535 13 AAVs aav NNS cord-024189-t7mbsr25 535 14 . . . cord-024189-t7mbsr25 536 1 In in IN cord-024189-t7mbsr25 536 2 some some DT cord-024189-t7mbsr25 536 3 cases case NNS cord-024189-t7mbsr25 536 4 , , , cord-024189-t7mbsr25 536 5 distinguishing distinguish VBG cord-024189-t7mbsr25 536 6 among among IN cord-024189-t7mbsr25 536 7 two two CD cord-024189-t7mbsr25 536 8 or or CC cord-024189-t7mbsr25 536 9 more more JJR cord-024189-t7mbsr25 536 10 of of IN cord-024189-t7mbsr25 536 11 these these DT cord-024189-t7mbsr25 536 12 diseases disease NNS cord-024189-t7mbsr25 536 13 on on IN cord-024189-t7mbsr25 536 14 the the DT cord-024189-t7mbsr25 536 15 basis basis NN cord-024189-t7mbsr25 536 16 of of IN cord-024189-t7mbsr25 536 17 clinical clinical JJ cord-024189-t7mbsr25 536 18 features feature NNS cord-024189-t7mbsr25 536 19 alone alone RB cord-024189-t7mbsr25 536 20 is be VBZ cord-024189-t7mbsr25 536 21 diffi diffi JJ cord-024189-t7mbsr25 536 22 cult cult NN cord-024189-t7mbsr25 536 23 ( ( -LRB- cord-024189-t7mbsr25 536 24 Table Table NNP cord-024189-t7mbsr25 536 25 21C-3 21c-3 CD cord-024189-t7mbsr25 536 26 ) ) -RRB- cord-024189-t7mbsr25 536 27 . . . cord-024189-t7mbsr25 537 1 Although although IN cord-024189-t7mbsr25 537 2 patients patient NNS cord-024189-t7mbsr25 537 3 with with IN cord-024189-t7mbsr25 537 4 the the DT cord-024189-t7mbsr25 537 5 CSS css NN cord-024189-t7mbsr25 537 6 or or CC cord-024189-t7mbsr25 537 7 MPA MPA NNP cord-024189-t7mbsr25 537 8 may may MD cord-024189-t7mbsr25 537 9 experience experience VB cord-024189-t7mbsr25 537 10 substantial substantial JJ cord-024189-t7mbsr25 537 11 ear ear NN cord-024189-t7mbsr25 537 12 , , , cord-024189-t7mbsr25 537 13 nose nose NN cord-024189-t7mbsr25 537 14 , , , cord-024189-t7mbsr25 537 15 or or CC cord-024189-t7mbsr25 537 16 sinus sinus NN cord-024189-t7mbsr25 537 17 disease disease NN cord-024189-t7mbsr25 537 18 , , , cord-024189-t7mbsr25 537 19 this this DT cord-024189-t7mbsr25 537 20 pattern pattern NN cord-024189-t7mbsr25 537 21 of of IN cord-024189-t7mbsr25 537 22 involvement involvement NN cord-024189-t7mbsr25 537 23 is be VBZ cord-024189-t7mbsr25 537 24 most most RBS cord-024189-t7mbsr25 537 25 characteristic characteristic JJ cord-024189-t7mbsr25 537 26 of of IN cord-024189-t7mbsr25 537 27 WG WG NNP cord-024189-t7mbsr25 537 28 . . . cord-024189-t7mbsr25 538 1 More More JJR cord-024189-t7mbsr25 538 2 than than IN cord-024189-t7mbsr25 538 3 90 90 CD cord-024189-t7mbsr25 538 4 % % NN cord-024189-t7mbsr25 538 5 of of IN cord-024189-t7mbsr25 538 6 patients patient NNS cord-024189-t7mbsr25 538 7 with with IN cord-024189-t7mbsr25 538 8 WG WG NNP cord-024189-t7mbsr25 538 9 eventually eventually RB cord-024189-t7mbsr25 538 10 develop develop VBP cord-024189-t7mbsr25 538 11 upper upper JJ cord-024189-t7mbsr25 538 12 airway airway NN cord-024189-t7mbsr25 538 13 or or CC cord-024189-t7mbsr25 538 14 ear ear NN cord-024189-t7mbsr25 538 15 abnormalities abnormality NNS cord-024189-t7mbsr25 538 16 . . . cord-024189-t7mbsr25 539 1 The the DT cord-024189-t7mbsr25 539 2 nasal nasal NN cord-024189-t7mbsr25 539 3 symptoms symptom NNS cord-024189-t7mbsr25 539 4 of of IN cord-024189-t7mbsr25 539 5 WG WG NNP cord-024189-t7mbsr25 539 6 include include VBP cord-024189-t7mbsr25 539 7 nasal nasal NN cord-024189-t7mbsr25 539 8 pain pain NN cord-024189-t7mbsr25 539 9 and and CC cord-024189-t7mbsr25 539 10 stuffi stuffi NNP cord-024189-t7mbsr25 539 11 ness ness NN cord-024189-t7mbsr25 539 12 , , , cord-024189-t7mbsr25 539 13 rhinitis rhinitis NN cord-024189-t7mbsr25 539 14 , , , cord-024189-t7mbsr25 539 15 epistaxis epistaxis NN cord-024189-t7mbsr25 539 16 , , , cord-024189-t7mbsr25 539 17 and and CC cord-024189-t7mbsr25 539 18 brown brown JJ cord-024189-t7mbsr25 539 19 or or CC cord-024189-t7mbsr25 539 20 bloody bloody JJ cord-024189-t7mbsr25 539 21 crusts crust NNS cord-024189-t7mbsr25 539 22 . . . cord-024189-t7mbsr25 540 1 Nasal nasal NN cord-024189-t7mbsr25 540 2 infl infl NN cord-024189-t7mbsr25 540 3 ammation ammation NN cord-024189-t7mbsr25 540 4 may may MD cord-024189-t7mbsr25 540 5 lead lead VB cord-024189-t7mbsr25 540 6 to to IN cord-024189-t7mbsr25 540 7 septal septal JJ cord-024189-t7mbsr25 540 8 erosions erosion NNS cord-024189-t7mbsr25 540 9 , , , cord-024189-t7mbsr25 540 10 septal septal JJ cord-024189-t7mbsr25 540 11 perforation perforation NN cord-024189-t7mbsr25 540 12 , , , cord-024189-t7mbsr25 540 13 or or CC cord-024189-t7mbsr25 540 14 , , , cord-024189-t7mbsr25 540 15 in in IN cord-024189-t7mbsr25 540 16 many many JJ cord-024189-t7mbsr25 540 17 cases case NNS cord-024189-t7mbsr25 540 18 , , , cord-024189-t7mbsr25 540 19 nasal nasal NN cord-024189-t7mbsr25 540 20 bridge bridge NN cord-024189-t7mbsr25 540 21 collapse collapse NN cord-024189-t7mbsr25 540 22 - - , cord-024189-t7mbsr25 540 23 the the DT cord-024189-t7mbsr25 540 24 " " `` cord-024189-t7mbsr25 540 25 saddle saddle NN cord-024189-t7mbsr25 540 26 - - HYPH cord-024189-t7mbsr25 540 27 nose nose NN cord-024189-t7mbsr25 540 28 deformity deformity NN cord-024189-t7mbsr25 540 29 " " '' cord-024189-t7mbsr25 540 30 ( ( -LRB- cord-024189-t7mbsr25 540 31 Figure figure NN cord-024189-t7mbsr25 540 32 21C 21c CD cord-024189-t7mbsr25 540 33 -1 -1 NN cord-024189-t7mbsr25 540 34 ) ) -RRB- cord-024189-t7mbsr25 540 35 . . . cord-024189-t7mbsr25 541 1 The the DT cord-024189-t7mbsr25 541 2 distinction distinction NN cord-024189-t7mbsr25 541 3 between between IN cord-024189-t7mbsr25 541 4 active active JJ cord-024189-t7mbsr25 541 5 WG WG NNP cord-024189-t7mbsr25 541 6 in in IN cord-024189-t7mbsr25 541 7 the the DT cord-024189-t7mbsr25 541 8 sinuses sinus NNS cord-024189-t7mbsr25 541 9 and and CC cord-024189-t7mbsr25 541 10 secondary secondary JJ cord-024189-t7mbsr25 541 11 infections infection NNS cord-024189-t7mbsr25 541 12 in in IN cord-024189-t7mbsr25 541 13 the the DT cord-024189-t7mbsr25 541 14 sinuses sinus NNS cord-024189-t7mbsr25 541 15 may may MD cord-024189-t7mbsr25 541 16 be be VB cord-024189-t7mbsr25 541 17 challenging challenging JJ cord-024189-t7mbsr25 541 18 ( ( -LRB- cord-024189-t7mbsr25 541 19 see see VB cord-024189-t7mbsr25 541 20 Nonmedical Nonmedical NNP cord-024189-t7mbsr25 541 21 Interventions Interventions NNPS cord-024189-t7mbsr25 541 22 section section NN cord-024189-t7mbsr25 541 23 ) ) -RRB- cord-024189-t7mbsr25 541 24 . . . cord-024189-t7mbsr25 542 1 In in IN cord-024189-t7mbsr25 542 2 60 60 CD cord-024189-t7mbsr25 542 3 % % NN cord-024189-t7mbsr25 542 4 to to TO cord-024189-t7mbsr25 542 5 70 70 CD cord-024189-t7mbsr25 542 6 % % NN cord-024189-t7mbsr25 542 7 of of IN cord-024189-t7mbsr25 542 8 patients patient NNS cord-024189-t7mbsr25 542 9 with with IN cord-024189-t7mbsr25 542 10 the the DT cord-024189-t7mbsr25 542 11 CSS css NN cord-024189-t7mbsr25 542 12 , , , cord-024189-t7mbsr25 542 13 allergic allergic JJ cord-024189-t7mbsr25 542 14 rhinitis rhinitis NN cord-024189-t7mbsr25 542 15 is be VBZ cord-024189-t7mbsr25 542 16 the the DT cord-024189-t7mbsr25 542 17 earliest early JJS cord-024189-t7mbsr25 542 18 disease disease NN cord-024189-t7mbsr25 542 19 manifestation manifestation NN cord-024189-t7mbsr25 542 20 , , , cord-024189-t7mbsr25 542 21 typically typically RB cord-024189-t7mbsr25 542 22 appearing appear VBG cord-024189-t7mbsr25 542 23 years year NNS cord-024189-t7mbsr25 542 24 before before IN cord-024189-t7mbsr25 542 25 the the DT cord-024189-t7mbsr25 542 26 development development NN cord-024189-t7mbsr25 542 27 of of IN cord-024189-t7mbsr25 542 28 full full RB cord-024189-t7mbsr25 542 29 - - HYPH cord-024189-t7mbsr25 542 30 blown blown JJ cord-024189-t7mbsr25 542 31 _SP cord-024189-t7mbsr25 542 32 Saddle Saddle NNP cord-024189-t7mbsr25 542 33 - - HYPH cord-024189-t7mbsr25 542 34 nose nose NN cord-024189-t7mbsr25 542 35 deformity deformity NN cord-024189-t7mbsr25 542 36 in in IN cord-024189-t7mbsr25 542 37 Wegener Wegener NNP cord-024189-t7mbsr25 542 38 's 's POS cord-024189-t7mbsr25 542 39 granulomatosis granulomatosis NN cord-024189-t7mbsr25 542 40 . . . cord-024189-t7mbsr25 543 1 systemic systemic JJ cord-024189-t7mbsr25 543 2 vasculitis vasculitis NN cord-024189-t7mbsr25 543 3 . . . cord-024189-t7mbsr25 544 1 Rhinitis Rhinitis NNP cord-024189-t7mbsr25 544 2 may may MD cord-024189-t7mbsr25 544 3 be be VB cord-024189-t7mbsr25 544 4 severe severe JJ cord-024189-t7mbsr25 544 5 and and CC cord-024189-t7mbsr25 544 6 may may MD cord-024189-t7mbsr25 544 7 require require VB cord-024189-t7mbsr25 544 8 serial serial JJ cord-024189-t7mbsr25 544 9 polypectomies polypectomy NNS cord-024189-t7mbsr25 544 10 to to TO cord-024189-t7mbsr25 544 11 relieve relieve VB cord-024189-t7mbsr25 544 12 obstruction obstruction NN cord-024189-t7mbsr25 544 13 and and CC cord-024189-t7mbsr25 544 14 sinusitis sinusitis NN cord-024189-t7mbsr25 544 15 . . . cord-024189-t7mbsr25 545 1 Nasal nasal NN cord-024189-t7mbsr25 545 2 crusting crusting NN cord-024189-t7mbsr25 545 3 and and CC cord-024189-t7mbsr25 545 4 conductive conductive JJ cord-024189-t7mbsr25 545 5 hearing hearing NN cord-024189-t7mbsr25 545 6 loss loss NN cord-024189-t7mbsr25 545 7 ( ( -LRB- cord-024189-t7mbsr25 545 8 due due IN cord-024189-t7mbsr25 545 9 to to IN cord-024189-t7mbsr25 545 10 serous serous JJ cord-024189-t7mbsr25 545 11 otitis otitis NN cord-024189-t7mbsr25 545 12 or or CC cord-024189-t7mbsr25 545 13 granulomatous granulomatous JJ cord-024189-t7mbsr25 545 14 middle middle JJ cord-024189-t7mbsr25 545 15 ear ear NN cord-024189-t7mbsr25 545 16 infl infl NN cord-024189-t7mbsr25 545 17 ammation ammation NNP cord-024189-t7mbsr25 545 18 ) ) -RRB- cord-024189-t7mbsr25 545 19 may may MD cord-024189-t7mbsr25 545 20 also also RB cord-024189-t7mbsr25 545 21 occur occur VB cord-024189-t7mbsr25 545 22 in in IN cord-024189-t7mbsr25 545 23 the the DT cord-024189-t7mbsr25 545 24 CSS css NN cord-024189-t7mbsr25 545 25 . . . cord-024189-t7mbsr25 546 1 Two two CD cord-024189-t7mbsr25 546 2 principal principal JJ cord-024189-t7mbsr25 546 3 categories category NNS cord-024189-t7mbsr25 546 4 of of IN cord-024189-t7mbsr25 546 5 ear ear NN cord-024189-t7mbsr25 546 6 disease disease NN cord-024189-t7mbsr25 546 7 - - HYPH cord-024189-t7mbsr25 546 8 conductive conductive JJ cord-024189-t7mbsr25 546 9 and and CC cord-024189-t7mbsr25 546 10 sensorineural sensorineural JJ cord-024189-t7mbsr25 546 11 hearing hearing NN cord-024189-t7mbsr25 546 12 loss loss NN cord-024189-t7mbsr25 546 13 - - : cord-024189-t7mbsr25 546 14 are be VBP cord-024189-t7mbsr25 546 15 typical typical JJ cord-024189-t7mbsr25 546 16 of of IN cord-024189-t7mbsr25 546 17 WG WG NNP cord-024189-t7mbsr25 546 18 . . . cord-024189-t7mbsr25 547 1 The the DT cord-024189-t7mbsr25 547 2 most most RBS cord-024189-t7mbsr25 547 3 common common JJ cord-024189-t7mbsr25 547 4 cause cause NN cord-024189-t7mbsr25 547 5 of of IN cord-024189-t7mbsr25 547 6 conductive conductive JJ cord-024189-t7mbsr25 547 7 hearing hearing NN cord-024189-t7mbsr25 547 8 loss loss NN cord-024189-t7mbsr25 547 9 may may MD cord-024189-t7mbsr25 547 10 be be VB cord-024189-t7mbsr25 547 11 Eustachian eustachian JJ cord-024189-t7mbsr25 547 12 tube tube NN cord-024189-t7mbsr25 547 13 dysfunction dysfunction NN cord-024189-t7mbsr25 547 14 due due IN cord-024189-t7mbsr25 547 15 to to IN cord-024189-t7mbsr25 547 16 nasopharyngeal nasopharyngeal JJ cord-024189-t7mbsr25 547 17 disease disease NN cord-024189-t7mbsr25 547 18 . . . cord-024189-t7mbsr25 548 1 Inner inner JJ cord-024189-t7mbsr25 548 2 ear ear NN cord-024189-t7mbsr25 548 3 disease disease NN cord-024189-t7mbsr25 548 4 in in IN cord-024189-t7mbsr25 548 5 WG WG NNP cord-024189-t7mbsr25 548 6 may may MD cord-024189-t7mbsr25 548 7 be be VB cord-024189-t7mbsr25 548 8 associated associate VBN cord-024189-t7mbsr25 548 9 with with IN cord-024189-t7mbsr25 548 10 sensorineural sensorineural JJ cord-024189-t7mbsr25 548 11 hearing hearing NN cord-024189-t7mbsr25 548 12 loss loss NN cord-024189-t7mbsr25 548 13 , , , cord-024189-t7mbsr25 548 14 vestibular vestibular JJ cord-024189-t7mbsr25 548 15 dysfunction dysfunction NN cord-024189-t7mbsr25 548 16 , , , cord-024189-t7mbsr25 548 17 or or CC cord-024189-t7mbsr25 548 18 both both DT cord-024189-t7mbsr25 548 19 . . . cord-024189-t7mbsr25 549 1 In in IN cord-024189-t7mbsr25 549 2 contrast contrast NN cord-024189-t7mbsr25 549 3 to to IN cord-024189-t7mbsr25 549 4 middle middle JJ cord-024189-t7mbsr25 549 5 ear ear NN cord-024189-t7mbsr25 549 6 disease disease NN cord-024189-t7mbsr25 549 7 , , , cord-024189-t7mbsr25 549 8 the the DT cord-024189-t7mbsr25 549 9 mechanism mechanism NN cord-024189-t7mbsr25 549 10 of of IN cord-024189-t7mbsr25 549 11 inner inner JJ cord-024189-t7mbsr25 549 12 ear ear NN cord-024189-t7mbsr25 549 13 disturbances disturbance NNS cord-024189-t7mbsr25 549 14 in in IN cord-024189-t7mbsr25 549 15 WG WG NNP cord-024189-t7mbsr25 549 16 is be VBZ cord-024189-t7mbsr25 549 17 poorly poorly RB cord-024189-t7mbsr25 549 18 understood understand VBN cord-024189-t7mbsr25 549 19 . . . cord-024189-t7mbsr25 550 1 Subglottic subglottic JJ cord-024189-t7mbsr25 550 2 stenosis stenosis NN cord-024189-t7mbsr25 550 3 and and CC cord-024189-t7mbsr25 550 4 stenotic stenotic JJ cord-024189-t7mbsr25 550 5 lesions lesion NNS cord-024189-t7mbsr25 550 6 of of IN cord-024189-t7mbsr25 550 7 the the DT cord-024189-t7mbsr25 550 8 bronchi bronchi NN cord-024189-t7mbsr25 550 9 are be VBP cord-024189-t7mbsr25 550 10 potentially potentially RB cord-024189-t7mbsr25 550 11 serious serious JJ cord-024189-t7mbsr25 550 12 complications complication NNS cord-024189-t7mbsr25 550 13 of of IN cord-024189-t7mbsr25 550 14 WG WG NNP cord-024189-t7mbsr25 550 15 . . . cord-024189-t7mbsr25 551 1 Subglottic subglottic JJ cord-024189-t7mbsr25 551 2 involvement involvement NN cord-024189-t7mbsr25 551 3 , , , cord-024189-t7mbsr25 551 4 often often RB cord-024189-t7mbsr25 551 5 asymptomatic asymptomatic JJ cord-024189-t7mbsr25 551 6 initially initially RB cord-024189-t7mbsr25 551 7 , , , cord-024189-t7mbsr25 551 8 becomes become VBZ cord-024189-t7mbsr25 551 9 apparent apparent JJ cord-024189-t7mbsr25 551 10 as as IN cord-024189-t7mbsr25 551 11 hoarseness hoarseness NN cord-024189-t7mbsr25 551 12 , , , cord-024189-t7mbsr25 551 13 pain pain NN cord-024189-t7mbsr25 551 14 , , , cord-024189-t7mbsr25 551 15 cough cough NN cord-024189-t7mbsr25 551 16 , , , cord-024189-t7mbsr25 551 17 wheezing wheezing NN cord-024189-t7mbsr25 551 18 , , , cord-024189-t7mbsr25 551 19 or or CC cord-024189-t7mbsr25 551 20 stridor stridor NNP cord-024189-t7mbsr25 551 21 . . . cord-024189-t7mbsr25 552 1 Thin thin JJ cord-024189-t7mbsr25 552 2 - - HYPH cord-024189-t7mbsr25 552 3 cut cut NN cord-024189-t7mbsr25 552 4 computed compute VBN cord-024189-t7mbsr25 552 5 tomographic tomographic JJ cord-024189-t7mbsr25 552 6 scans scan NNS cord-024189-t7mbsr25 552 7 and and CC cord-024189-t7mbsr25 552 8 often often RB cord-024189-t7mbsr25 552 9 direct direct JJ cord-024189-t7mbsr25 552 10 laryngoscopy laryngoscopy NNS cord-024189-t7mbsr25 552 11 are be VBP cord-024189-t7mbsr25 552 12 useful useful JJ cord-024189-t7mbsr25 552 13 in in IN cord-024189-t7mbsr25 552 14 assessing assess VBG cord-024189-t7mbsr25 552 15 these these DT cord-024189-t7mbsr25 552 16 airway airway NN cord-024189-t7mbsr25 552 17 narrowings narrowing NNS cord-024189-t7mbsr25 552 18 . . . cord-024189-t7mbsr25 553 1 Scleritis Scleritis NNP cord-024189-t7mbsr25 553 2 may may MD cord-024189-t7mbsr25 553 3 lead lead VB cord-024189-t7mbsr25 553 4 to to IN cord-024189-t7mbsr25 553 5 necrotizing necrotize VBG cord-024189-t7mbsr25 553 6 anterior anterior FW cord-024189-t7mbsr25 553 7 scleritis scleritis NNP cord-024189-t7mbsr25 553 8 ( ( -LRB- cord-024189-t7mbsr25 553 9 scleromalacia scleromalacia NNP cord-024189-t7mbsr25 553 10 perforans perforans NNPS cord-024189-t7mbsr25 553 11 ) ) -RRB- cord-024189-t7mbsr25 553 12 and and CC cord-024189-t7mbsr25 553 13 blindness blindness NN cord-024189-t7mbsr25 553 14 . . . cord-024189-t7mbsr25 554 1 Peripheral peripheral JJ cord-024189-t7mbsr25 554 2 ulcerative ulcerative JJ cord-024189-t7mbsr25 554 3 keratitis keratitis NN cord-024189-t7mbsr25 554 4 may may MD cord-024189-t7mbsr25 554 5 cause cause VB cord-024189-t7mbsr25 554 6 the the DT cord-024189-t7mbsr25 554 7 corneal corneal JJ cord-024189-t7mbsr25 554 8 melt melt NN cord-024189-t7mbsr25 554 9 syndrome syndrome NN cord-024189-t7mbsr25 554 10 . . . cord-024189-t7mbsr25 555 1 Other other JJ cord-024189-t7mbsr25 555 2 ocular ocular JJ cord-024189-t7mbsr25 555 3 manifestations manifestation NNS cord-024189-t7mbsr25 555 4 of of IN cord-024189-t7mbsr25 555 5 AAV AAV NNP cord-024189-t7mbsr25 555 6 include include VBP cord-024189-t7mbsr25 555 7 conjunctivitis conjunctivitis NN cord-024189-t7mbsr25 555 8 , , , cord-024189-t7mbsr25 555 9 episcleritis episcleritis NN cord-024189-t7mbsr25 555 10 , , , cord-024189-t7mbsr25 555 11 and and CC cord-024189-t7mbsr25 555 12 anterior anterior JJ cord-024189-t7mbsr25 555 13 uveitis uveitis NN cord-024189-t7mbsr25 555 14 . . . cord-024189-t7mbsr25 556 1 In in IN cord-024189-t7mbsr25 556 2 WG WG NNP cord-024189-t7mbsr25 556 3 , , , cord-024189-t7mbsr25 556 4 orbital orbital JJ cord-024189-t7mbsr25 556 5 masses masse NNS cord-024189-t7mbsr25 556 6 termed term VBN cord-024189-t7mbsr25 556 7 pseudotumors pseudotumor NNS cord-024189-t7mbsr25 556 8 occur occur VBP cord-024189-t7mbsr25 556 9 in in IN cord-024189-t7mbsr25 556 10 a a DT cord-024189-t7mbsr25 556 11 retrobulbar retrobulbar NN cord-024189-t7mbsr25 556 12 location location NN cord-024189-t7mbsr25 556 13 in in IN cord-024189-t7mbsr25 556 14 10 10 CD cord-024189-t7mbsr25 556 15 % % NN cord-024189-t7mbsr25 556 16 to to TO cord-024189-t7mbsr25 556 17 15 15 CD cord-024189-t7mbsr25 556 18 % % NN cord-024189-t7mbsr25 556 19 of of IN cord-024189-t7mbsr25 556 20 patients patient NNS cord-024189-t7mbsr25 556 21 , , , cord-024189-t7mbsr25 556 22 causing cause VBG cord-024189-t7mbsr25 556 23 proptosis proptosis NN cord-024189-t7mbsr25 556 24 , , , cord-024189-t7mbsr25 556 25 diplopia diplopia NN cord-024189-t7mbsr25 556 26 , , , cord-024189-t7mbsr25 556 27 or or CC cord-024189-t7mbsr25 556 28 visual visual JJ cord-024189-t7mbsr25 556 29 loss loss NN cord-024189-t7mbsr25 556 30 . . . cord-024189-t7mbsr25 557 1 Nasolacrimal nasolacrimal JJ cord-024189-t7mbsr25 557 2 duct duct NN cord-024189-t7mbsr25 557 3 obstruction obstruction NN cord-024189-t7mbsr25 557 4 is be VBZ cord-024189-t7mbsr25 557 5 most most RBS cord-024189-t7mbsr25 557 6 typical typical JJ cord-024189-t7mbsr25 557 7 of of IN cord-024189-t7mbsr25 557 8 WG WG NNP cord-024189-t7mbsr25 557 9 . . . cord-024189-t7mbsr25 558 1 In in IN cord-024189-t7mbsr25 558 2 WG WG NNP cord-024189-t7mbsr25 558 3 , , , cord-024189-t7mbsr25 558 4 the the DT cord-024189-t7mbsr25 558 5 pulmonary pulmonary JJ cord-024189-t7mbsr25 558 6 manifestations manifestation NNS cord-024189-t7mbsr25 558 7 range range VBP cord-024189-t7mbsr25 558 8 from from IN cord-024189-t7mbsr25 558 9 asymptomatic asymptomatic JJ cord-024189-t7mbsr25 558 10 lung lung NN cord-024189-t7mbsr25 558 11 nodules nodule NNS cord-024189-t7mbsr25 558 12 and and CC cord-024189-t7mbsr25 558 13 fl fl NNP cord-024189-t7mbsr25 558 14 eeting eeting NNP cord-024189-t7mbsr25 558 15 ( ( -LRB- cord-024189-t7mbsr25 558 16 or or CC cord-024189-t7mbsr25 558 17 fi fi NN cord-024189-t7mbsr25 558 18 xed xed NNP cord-024189-t7mbsr25 558 19 ) ) -RRB- cord-024189-t7mbsr25 559 1 pulmonary pulmonary NNP cord-024189-t7mbsr25 559 2 infi infi NNP cord-024189-t7mbsr25 559 3 ltrates ltrates NNP cord-024189-t7mbsr25 559 4 to to TO cord-024189-t7mbsr25 559 5 fulminant fulminant JJ cord-024189-t7mbsr25 559 6 alveolar alveolar NN cord-024189-t7mbsr25 559 7 hemorrhage hemorrhage NN cord-024189-t7mbsr25 559 8 . . . cord-024189-t7mbsr25 560 1 The the DT cord-024189-t7mbsr25 560 2 nodules nodule NNS cord-024189-t7mbsr25 560 3 are be VBP cord-024189-t7mbsr25 560 4 usually usually RB cord-024189-t7mbsr25 560 5 multiple multiple JJ cord-024189-t7mbsr25 560 6 , , , cord-024189-t7mbsr25 560 7 bilateral bilateral JJ cord-024189-t7mbsr25 560 8 ( ( -LRB- cord-024189-t7mbsr25 560 9 Figure figure NN cord-024189-t7mbsr25 560 10 21C-2 21c-2 CD cord-024189-t7mbsr25 560 11 ) ) -RRB- cord-024189-t7mbsr25 560 12 , , , cord-024189-t7mbsr25 560 13 and and CC cord-024189-t7mbsr25 560 14 often often RB cord-024189-t7mbsr25 560 15 cavitary cavitary JJ cord-024189-t7mbsr25 560 16 . . . cord-024189-t7mbsr25 561 1 Infi Infi NNP cord-024189-t7mbsr25 561 2 ltrates ltrate NNS cord-024189-t7mbsr25 561 3 are be VBP cord-024189-t7mbsr25 561 4 often often RB cord-024189-t7mbsr25 561 5 misdiagnosed misdiagnose VBN cord-024189-t7mbsr25 561 6 initially initially RB cord-024189-t7mbsr25 561 7 as as IN cord-024189-t7mbsr25 561 8 pneumonia pneumonia NN cord-024189-t7mbsr25 561 9 . . . cord-024189-t7mbsr25 562 1 Pulmonary pulmonary JJ cord-024189-t7mbsr25 562 2 capillaritis capillaritis NN cord-024189-t7mbsr25 562 3 , , , cord-024189-t7mbsr25 562 4 equally equally RB cord-024189-t7mbsr25 562 5 likely likely JJ cord-024189-t7mbsr25 562 6 to to TO cord-024189-t7mbsr25 562 7 occur occur VB cord-024189-t7mbsr25 562 8 in in IN cord-024189-t7mbsr25 562 9 WG WG NNP cord-024189-t7mbsr25 562 10 and and CC cord-024189-t7mbsr25 562 11 MPA MPA NNP cord-024189-t7mbsr25 562 12 , , , cord-024189-t7mbsr25 562 13 may may MD cord-024189-t7mbsr25 562 14 lead lead VB cord-024189-t7mbsr25 562 15 to to IN cord-024189-t7mbsr25 562 16 lung lung NN cord-024189-t7mbsr25 562 17 hemorrhage hemorrhage NN cord-024189-t7mbsr25 562 18 , , , cord-024189-t7mbsr25 562 19 hemoptysis hemoptysis NN cord-024189-t7mbsr25 562 20 , , , cord-024189-t7mbsr25 562 21 and and CC cord-024189-t7mbsr25 562 22 rapidly rapidly RB cord-024189-t7mbsr25 562 23 changing change VBG cord-024189-t7mbsr25 562 24 alveolar alveolar JJ cord-024189-t7mbsr25 562 25 infi infi NNP cord-024189-t7mbsr25 562 26 ltrates ltrates NNP cord-024189-t7mbsr25 562 27 ( ( -LRB- cord-024189-t7mbsr25 562 28 Figure Figure NNP cord-024189-t7mbsr25 562 29 21C-3 21c-3 CD cord-024189-t7mbsr25 562 30 ) ) -RRB- cord-024189-t7mbsr25 562 31 . . . cord-024189-t7mbsr25 563 1 Patients patient NNS cord-024189-t7mbsr25 563 2 with with IN cord-024189-t7mbsr25 563 3 MPA MPA NNP cord-024189-t7mbsr25 563 4 may may MD cord-024189-t7mbsr25 563 5 also also RB cord-024189-t7mbsr25 563 6 develop develop VB cord-024189-t7mbsr25 563 7 interstitial interstitial JJ cord-024189-t7mbsr25 563 8 fi fi NN cord-024189-t7mbsr25 563 9 brosis brosis NN cord-024189-t7mbsr25 563 10 of of IN cord-024189-t7mbsr25 563 11 the the DT cord-024189-t7mbsr25 563 12 lungs lung NNS cord-024189-t7mbsr25 563 13 . . . cord-024189-t7mbsr25 564 1 Obstructive obstructive JJ cord-024189-t7mbsr25 564 2 airway airway NN cord-024189-t7mbsr25 564 3 disease disease NN cord-024189-t7mbsr25 564 4 and and CC cord-024189-t7mbsr25 564 5 fl fl NNP cord-024189-t7mbsr25 564 6 eeting eete VBG cord-024189-t7mbsr25 564 7 pulmonary pulmonary NNP cord-024189-t7mbsr25 564 8 infi infi NNP cord-024189-t7mbsr25 564 9 ltrates ltrates NNP cord-024189-t7mbsr25 564 10 are be VBP cord-024189-t7mbsr25 564 11 the the DT cord-024189-t7mbsr25 564 12 hallmarks hallmark NNS cord-024189-t7mbsr25 564 13 of of IN cord-024189-t7mbsr25 564 14 the the DT cord-024189-t7mbsr25 564 15 CSS css NN cord-024189-t7mbsr25 564 16 . . . cord-024189-t7mbsr25 565 1 The the DT cord-024189-t7mbsr25 565 2 majority majority NN cord-024189-t7mbsr25 565 3 of of IN cord-024189-t7mbsr25 565 4 patients patient NNS cord-024189-t7mbsr25 565 5 report report VBP cord-024189-t7mbsr25 565 6 the the DT cord-024189-t7mbsr25 565 7 new new JJ cord-024189-t7mbsr25 565 8 onset onset NN cord-024189-t7mbsr25 565 9 of of IN cord-024189-t7mbsr25 565 10 asthma asthma NN cord-024189-t7mbsr25 565 11 months month NNS cord-024189-t7mbsr25 565 12 to to IN cord-024189-t7mbsr25 565 13 years year NNS cord-024189-t7mbsr25 565 14 before before IN cord-024189-t7mbsr25 565 15 the the DT cord-024189-t7mbsr25 565 16 appearance appearance NN cord-024189-t7mbsr25 565 17 of of IN cord-024189-t7mbsr25 565 18 overt overt JJ cord-024189-t7mbsr25 565 19 vasculitis vasculitis NN cord-024189-t7mbsr25 565 20 . . . cord-024189-t7mbsr25 566 1 Following follow VBG cord-024189-t7mbsr25 566 2 resolution resolution NN cord-024189-t7mbsr25 566 3 of of IN cord-024189-t7mbsr25 566 4 the the DT cord-024189-t7mbsr25 566 5 vasculitic vasculitic JJ cord-024189-t7mbsr25 566 6 phase phase NN cord-024189-t7mbsr25 566 7 with with IN cord-024189-t7mbsr25 566 8 treatment treatment NN cord-024189-t7mbsr25 566 9 , , , cord-024189-t7mbsr25 566 10 many many JJ cord-024189-t7mbsr25 566 11 patients patient NNS cord-024189-t7mbsr25 566 12 with with IN cord-024189-t7mbsr25 566 13 CSS CSS NNP cord-024189-t7mbsr25 566 14 suffer suffer VBP cord-024189-t7mbsr25 566 15 from from IN cord-024189-t7mbsr25 566 16 steroid steroid NN cord-024189-t7mbsr25 566 17 - - HYPH cord-024189-t7mbsr25 566 18 dependent dependent JJ cord-024189-t7mbsr25 566 19 asthma asthma NN cord-024189-t7mbsr25 566 20 . . . cord-024189-t7mbsr25 567 1 The the DT cord-024189-t7mbsr25 567 2 most most RBS cord-024189-t7mbsr25 567 3 feared fear VBN cord-024189-t7mbsr25 567 4 clinical clinical JJ cord-024189-t7mbsr25 567 5 presentation presentation NN cord-024189-t7mbsr25 567 6 of of IN cord-024189-t7mbsr25 567 7 renal renal JJ cord-024189-t7mbsr25 567 8 disease disease NN cord-024189-t7mbsr25 567 9 among among IN cord-024189-t7mbsr25 567 10 the the DT cord-024189-t7mbsr25 567 11 AAVs aav NNS cord-024189-t7mbsr25 567 12 is be VBZ cord-024189-t7mbsr25 567 13 rapidly rapidly RB cord-024189-t7mbsr25 567 14 progressive progressive JJ cord-024189-t7mbsr25 567 15 glomerulonephritis glomerulonephritis NN cord-024189-t7mbsr25 567 16 . . . cord-024189-t7mbsr25 568 1 More More JJR cord-024189-t7mbsr25 568 2 than than IN cord-024189-t7mbsr25 568 3 75 75 CD cord-024189-t7mbsr25 568 4 % % NN cord-024189-t7mbsr25 568 5 of of IN cord-024189-t7mbsr25 568 6 patients patient NNS cord-024189-t7mbsr25 568 7 with with IN cord-024189-t7mbsr25 568 8 WG WG NNP cord-024189-t7mbsr25 568 9 will will MD cord-024189-t7mbsr25 568 10 eventually eventually RB cord-024189-t7mbsr25 568 11 develop develop VB cord-024189-t7mbsr25 568 12 renal renal JJ cord-024189-t7mbsr25 568 13 involvement involvement NN cord-024189-t7mbsr25 568 14 . . . cord-024189-t7mbsr25 569 1 The the DT cord-024189-t7mbsr25 569 2 progression progression NN cord-024189-t7mbsr25 569 3 of of IN cord-024189-t7mbsr25 569 4 the the DT cord-024189-t7mbsr25 569 5 disease disease NN cord-024189-t7mbsr25 569 6 often often RB cord-024189-t7mbsr25 569 7 appears appear VBZ cord-024189-t7mbsr25 569 8 to to TO cord-024189-t7mbsr25 569 9 accelerate accelerate VB cord-024189-t7mbsr25 569 10 once once RB cord-024189-t7mbsr25 569 11 kidney kidney NN cord-024189-t7mbsr25 569 12 involvement involvement NN cord-024189-t7mbsr25 569 13 is be VBZ cord-024189-t7mbsr25 569 14 apparent apparent JJ cord-024189-t7mbsr25 569 15 . . . cord-024189-t7mbsr25 570 1 In in IN cord-024189-t7mbsr25 570 2 MPA MPA NNP cord-024189-t7mbsr25 570 3 , , , cord-024189-t7mbsr25 570 4 renal renal JJ cord-024189-t7mbsr25 570 5 disease disease NN cord-024189-t7mbsr25 570 6 may may MD cord-024189-t7mbsr25 570 7 have have VB cord-024189-t7mbsr25 570 8 a a DT cord-024189-t7mbsr25 570 9 more more RBR cord-024189-t7mbsr25 570 10 indolent indolent JJ cord-024189-t7mbsr25 570 11 course course NN cord-024189-t7mbsr25 570 12 , , , cord-024189-t7mbsr25 570 13 and and CC cord-024189-t7mbsr25 570 14 renal renal JJ cord-024189-t7mbsr25 570 15 biopsies biopsy NNS cord-024189-t7mbsr25 570 16 typically typically RB cord-024189-t7mbsr25 570 17 demonstrate demonstrate VBP cord-024189-t7mbsr25 570 18 more more JJR cord-024189-t7mbsr25 570 19 sclerosis sclerosis NN cord-024189-t7mbsr25 570 20 and and CC cord-024189-t7mbsr25 570 21 fi fi NN cord-024189-t7mbsr25 570 22 brosis brosis NN cord-024189-t7mbsr25 570 23 than than IN cord-024189-t7mbsr25 570 24 do do VB cord-024189-t7mbsr25 570 25 specimens specimen NNS cord-024189-t7mbsr25 570 26 from from IN cord-024189-t7mbsr25 570 27 patients patient NNS cord-024189-t7mbsr25 570 28 with with IN cord-024189-t7mbsr25 570 29 WG WG NNP cord-024189-t7mbsr25 570 30 . . . cord-024189-t7mbsr25 571 1 Severe severe JJ cord-024189-t7mbsr25 571 2 renal renal JJ cord-024189-t7mbsr25 571 3 disease disease NN cord-024189-t7mbsr25 571 4 in in IN cord-024189-t7mbsr25 571 5 CSS CSS NNP cord-024189-t7mbsr25 571 6 is be VBZ cord-024189-t7mbsr25 571 7 very very RB cord-024189-t7mbsr25 571 8 rare rare JJ cord-024189-t7mbsr25 571 9 . . . cord-024189-t7mbsr25 572 1 " " '' cord-024189-t7mbsr25 573 1 Renal renal JJ cord-024189-t7mbsr25 573 2 - - HYPH cord-024189-t7mbsr25 573 3 limited limited JJ cord-024189-t7mbsr25 573 4 " " '' cord-024189-t7mbsr25 573 5 vasculitis vasculitis NN cord-024189-t7mbsr25 573 6 is be VBZ cord-024189-t7mbsr25 573 7 pauci pauci NN cord-024189-t7mbsr25 573 8 - - HYPH cord-024189-t7mbsr25 573 9 immune immune JJ cord-024189-t7mbsr25 573 10 glomerulonephritis glomerulonephritis NN cord-024189-t7mbsr25 573 11 ( ( -LRB- cord-024189-t7mbsr25 573 12 see see VB cord-024189-t7mbsr25 573 13 Pathology pathology NN cord-024189-t7mbsr25 573 14 section section NN cord-024189-t7mbsr25 573 15 ) ) -RRB- cord-024189-t7mbsr25 573 16 associated associate VBN cord-024189-t7mbsr25 573 17 with with IN cord-024189-t7mbsr25 573 18 ANCA ANCA NNP cord-024189-t7mbsr25 573 19 , , , cord-024189-t7mbsr25 573 20 usually usually RB cord-024189-t7mbsr25 573 21 directed direct VBN cord-024189-t7mbsr25 573 22 against against IN cord-024189-t7mbsr25 573 23 MPO MPO NNP cord-024189-t7mbsr25 573 24 , , , cord-024189-t7mbsr25 573 25 without without IN cord-024189-t7mbsr25 573 26 evidence evidence NN cord-024189-t7mbsr25 573 27 of of IN cord-024189-t7mbsr25 573 28 disease disease NN cord-024189-t7mbsr25 573 29 in in IN cord-024189-t7mbsr25 573 30 other other JJ cord-024189-t7mbsr25 573 31 organs organ NNS cord-024189-t7mbsr25 573 32 . . . cord-024189-t7mbsr25 574 1 ANCA ANCA NNP cord-024189-t7mbsr25 574 2 - - HYPH cord-024189-t7mbsr25 574 3 associated associate VBN cord-024189-t7mbsr25 574 4 renal renal JJ cord-024189-t7mbsr25 574 5 disease disease NN cord-024189-t7mbsr25 574 6 may may MD cord-024189-t7mbsr25 574 7 lead lead VB cord-024189-t7mbsr25 574 8 to to IN cord-024189-t7mbsr25 574 9 fi fi NNP cord-024189-t7mbsr25 574 10 brotic brotic JJ cord-024189-t7mbsr25 574 11 crescents crescent NNS cord-024189-t7mbsr25 574 12 and and CC cord-024189-t7mbsr25 574 13 other other JJ cord-024189-t7mbsr25 574 14 scarring scarring NN cord-024189-t7mbsr25 574 15 within within IN cord-024189-t7mbsr25 574 16 the the DT cord-024189-t7mbsr25 574 17 kidney kidney NN cord-024189-t7mbsr25 574 18 . . . cord-024189-t7mbsr25 575 1 Subsequent subsequent JJ cord-024189-t7mbsr25 575 2 disease disease NN cord-024189-t7mbsr25 575 3 fl fl NNP cord-024189-t7mbsr25 575 4 ares ares NNP cord-024189-t7mbsr25 575 5 and and CC cord-024189-t7mbsr25 575 6 progression progression NN cord-024189-t7mbsr25 575 7 of of IN cord-024189-t7mbsr25 575 8 renal renal JJ cord-024189-t7mbsr25 575 9 dysfunction dysfunction NN cord-024189-t7mbsr25 575 10 through through IN cord-024189-t7mbsr25 575 11 hyperfi hyperfi NNP cord-024189-t7mbsr25 575 12 ltration ltration NN cord-024189-t7mbsr25 575 13 may may MD cord-024189-t7mbsr25 575 14 lead lead VB cord-024189-t7mbsr25 575 15 to to IN cord-024189-t7mbsr25 575 16 end end NN cord-024189-t7mbsr25 575 17 - - HYPH cord-024189-t7mbsr25 575 18 stage stage NN cord-024189-t7mbsr25 575 19 renal renal JJ cord-024189-t7mbsr25 575 20 disease disease NN cord-024189-t7mbsr25 575 21 . . . cord-024189-t7mbsr25 576 1 Infl Infl NNP cord-024189-t7mbsr25 576 2 ammatory ammatory NN cord-024189-t7mbsr25 576 3 joint joint JJ cord-024189-t7mbsr25 576 4 complaints complaint NNS cord-024189-t7mbsr25 576 5 , , , cord-024189-t7mbsr25 576 6 often often RB cord-024189-t7mbsr25 576 7 migratory migratory JJ cord-024189-t7mbsr25 576 8 and and CC cord-024189-t7mbsr25 576 9 oligoarticular oligoarticular JJ cord-024189-t7mbsr25 576 10 in in IN cord-024189-t7mbsr25 576 11 nature nature NN cord-024189-t7mbsr25 576 12 , , , cord-024189-t7mbsr25 576 13 occur occur VBP cord-024189-t7mbsr25 576 14 in in IN cord-024189-t7mbsr25 576 15 at at RB cord-024189-t7mbsr25 576 16 least least RBS cord-024189-t7mbsr25 576 17 60 60 CD cord-024189-t7mbsr25 576 18 % % NN cord-024189-t7mbsr25 576 19 of of IN cord-024189-t7mbsr25 576 20 patients patient NNS cord-024189-t7mbsr25 576 21 with with IN cord-024189-t7mbsr25 576 22 AAV AAV NNP cord-024189-t7mbsr25 576 23 . . . cord-024189-t7mbsr25 577 1 Joint joint JJ cord-024189-t7mbsr25 577 2 problems problem NNS cord-024189-t7mbsr25 577 3 are be VBP cord-024189-t7mbsr25 577 4 frequently frequently RB cord-024189-t7mbsr25 577 5 the the DT cord-024189-t7mbsr25 577 6 presenting present VBG cord-024189-t7mbsr25 577 7 complaint complaint NN cord-024189-t7mbsr25 577 8 , , , cord-024189-t7mbsr25 577 9 but but CC cord-024189-t7mbsr25 577 10 the the DT cord-024189-t7mbsr25 577 11 diagnosis diagnosis NN cord-024189-t7mbsr25 577 12 is be VBZ cord-024189-t7mbsr25 577 13 seldom seldom RB cord-024189-t7mbsr25 577 14 made make VBN cord-024189-t7mbsr25 577 15 until until IN cord-024189-t7mbsr25 577 16 other other JJ cord-024189-t7mbsr25 577 17 symptoms symptom NNS cord-024189-t7mbsr25 577 18 are be VBP cord-024189-t7mbsr25 577 19 manifest manifest JJ cord-024189-t7mbsr25 577 20 . . . cord-024189-t7mbsr25 578 1 The the DT cord-024189-t7mbsr25 578 2 combination combination NN cord-024189-t7mbsr25 578 3 of of IN cord-024189-t7mbsr25 578 4 joint joint JJ cord-024189-t7mbsr25 578 5 complaints complaint NNS cord-024189-t7mbsr25 578 6 , , , cord-024189-t7mbsr25 578 7 cutaneous cutaneous JJ cord-024189-t7mbsr25 578 8 nodules nodule NNS cord-024189-t7mbsr25 578 9 ( ( -LRB- cord-024189-t7mbsr25 578 10 frequently frequently RB cord-024189-t7mbsr25 578 11 mistaken mistake VBN cord-024189-t7mbsr25 578 12 for for IN cord-024189-t7mbsr25 578 13 rheumatoid rheumatoid NN cord-024189-t7mbsr25 578 14 nodules nodule NNS cord-024189-t7mbsr25 578 15 ) ) -RRB- cord-024189-t7mbsr25 578 16 , , , cord-024189-t7mbsr25 578 17 and and CC cord-024189-t7mbsr25 578 18 the the DT cord-024189-t7mbsr25 578 19 high high JJ cord-024189-t7mbsr25 578 20 frequency frequency NN cord-024189-t7mbsr25 578 21 of of IN cord-024189-t7mbsr25 578 22 rheumatoid rheumatoid NN cord-024189-t7mbsr25 578 23 factor factor NN cord-024189-t7mbsr25 578 24 positivity positivity NN cord-024189-t7mbsr25 578 25 among among IN cord-024189-t7mbsr25 578 26 patients patient NNS cord-024189-t7mbsr25 578 27 with with IN cord-024189-t7mbsr25 578 28 AAV AAV NNP cord-024189-t7mbsr25 578 29 ( ( -LRB- cord-024189-t7mbsr25 578 30 approximately approximately RB cord-024189-t7mbsr25 578 31 one one CD cord-024189-t7mbsr25 578 32 third third NN cord-024189-t7mbsr25 578 33 are be VBP cord-024189-t7mbsr25 578 34 rheumatoid rheumatoid NN cord-024189-t7mbsr25 578 35 factor factor NN cord-024189-t7mbsr25 578 36 positive positive JJ cord-024189-t7mbsr25 578 37 ) ) -RRB- cord-024189-t7mbsr25 578 38 often often RB cord-024189-t7mbsr25 578 39 lead lead VBP cord-024189-t7mbsr25 578 40 to to IN cord-024189-t7mbsr25 578 41 the the DT cord-024189-t7mbsr25 578 42 misdiagnosis misdiagnosis NN cord-024189-t7mbsr25 578 43 of of IN cord-024189-t7mbsr25 578 44 rheumatoid rheumatoid JJ cord-024189-t7mbsr25 578 45 arthritis arthritis NN cord-024189-t7mbsr25 578 46 early early RB cord-024189-t7mbsr25 578 47 in in IN cord-024189-t7mbsr25 578 48 the the DT cord-024189-t7mbsr25 578 49 disease disease NN cord-024189-t7mbsr25 578 50 course course NN cord-024189-t7mbsr25 578 51 . . . cord-024189-t7mbsr25 579 1 Arthralgias Arthralgias NNP cord-024189-t7mbsr25 579 2 are be VBP cord-024189-t7mbsr25 579 3 more more RBR cord-024189-t7mbsr25 579 4 common common JJ cord-024189-t7mbsr25 579 5 than than IN cord-024189-t7mbsr25 579 6 frank frank JJ cord-024189-t7mbsr25 579 7 arthritis arthritis NN cord-024189-t7mbsr25 579 8 . . . cord-024189-t7mbsr25 580 1 The the DT cord-024189-t7mbsr25 580 2 recurrence recurrence NN cord-024189-t7mbsr25 580 3 of of IN cord-024189-t7mbsr25 580 4 musculoskeletal musculoskeletal JJ cord-024189-t7mbsr25 580 5 complaints complaint NNS cord-024189-t7mbsr25 580 6 in in IN cord-024189-t7mbsr25 580 7 a a DT cord-024189-t7mbsr25 580 8 patient patient NN cord-024189-t7mbsr25 580 9 in in IN cord-024189-t7mbsr25 580 10 remission remission NN cord-024189-t7mbsr25 580 11 often often RB cord-024189-t7mbsr25 580 12 marks mark VBZ cord-024189-t7mbsr25 580 13 the the DT cord-024189-t7mbsr25 580 14 start start NN cord-024189-t7mbsr25 580 15 of of IN cord-024189-t7mbsr25 580 16 a a DT cord-024189-t7mbsr25 580 17 disease disease NN cord-024189-t7mbsr25 580 18 fl fl NNP cord-024189-t7mbsr25 580 19 are be VBP cord-024189-t7mbsr25 580 20 . . . cord-024189-t7mbsr25 581 1 In in IN cord-024189-t7mbsr25 581 2 both both CC cord-024189-t7mbsr25 581 3 the the DT cord-024189-t7mbsr25 581 4 CSS CSS NNP cord-024189-t7mbsr25 581 5 and and CC cord-024189-t7mbsr25 581 6 WG WG NNP cord-024189-t7mbsr25 581 7 , , , cord-024189-t7mbsr25 581 8 cutaneous cutaneous JJ cord-024189-t7mbsr25 581 9 nodules nodule NNS cord-024189-t7mbsr25 581 10 may may MD cord-024189-t7mbsr25 581 11 occur occur VB cord-024189-t7mbsr25 581 12 at at IN cord-024189-t7mbsr25 581 13 sites site NNS cord-024189-t7mbsr25 581 14 that that WDT cord-024189-t7mbsr25 581 15 are be VBP cord-024189-t7mbsr25 581 16 also also RB cord-024189-t7mbsr25 581 17 common common JJ cord-024189-t7mbsr25 581 18 locations location NNS cord-024189-t7mbsr25 581 19 for for IN cord-024189-t7mbsr25 581 20 rheumatoid rheumatoid NN cord-024189-t7mbsr25 581 21 nodules nodule NNS cord-024189-t7mbsr25 581 22 , , , cord-024189-t7mbsr25 581 23 particularly particularly RB cord-024189-t7mbsr25 581 24 the the DT cord-024189-t7mbsr25 581 25 olecranon olecranon NN cord-024189-t7mbsr25 581 26 region region NN cord-024189-t7mbsr25 581 27 ( ( -LRB- cord-024189-t7mbsr25 581 28 Figure figure NN cord-024189-t7mbsr25 581 29 _SP cord-024189-t7mbsr25 581 30 21C-4 21c-4 CD cord-024189-t7mbsr25 581 31 ) ) -RRB- cord-024189-t7mbsr25 581 32 . . . cord-024189-t7mbsr25 582 1 Skin skin NN cord-024189-t7mbsr25 582 2 fi fi NN cord-024189-t7mbsr25 582 3 ndings nding NNS cord-024189-t7mbsr25 582 4 in in IN cord-024189-t7mbsr25 582 5 the the DT cord-024189-t7mbsr25 582 6 AAVs aav NNS cord-024189-t7mbsr25 582 7 also also RB cord-024189-t7mbsr25 582 8 include include VBP cord-024189-t7mbsr25 582 9 all all DT cord-024189-t7mbsr25 582 10 of of IN cord-024189-t7mbsr25 582 11 the the DT cord-024189-t7mbsr25 582 12 potential potential JJ cord-024189-t7mbsr25 582 13 manifestations manifestation NNS cord-024189-t7mbsr25 582 14 of of IN cord-024189-t7mbsr25 582 15 cutaneous cutaneous JJ cord-024189-t7mbsr25 582 16 vasculitis vasculitis NN cord-024189-t7mbsr25 582 17 : : : cord-024189-t7mbsr25 582 18 palpable palpable JJ cord-024189-t7mbsr25 582 19 purpura purpura NN cord-024189-t7mbsr25 582 20 , , , cord-024189-t7mbsr25 582 21 vesiculobullous vesiculobullous JJ cord-024189-t7mbsr25 582 22 lesions lesion NNS cord-024189-t7mbsr25 582 23 , , , cord-024189-t7mbsr25 582 24 papules papule NNS cord-024189-t7mbsr25 582 25 , , , cord-024189-t7mbsr25 582 26 ulcers ulcer NNS cord-024189-t7mbsr25 582 27 , , , cord-024189-t7mbsr25 582 28 digital digital JJ cord-024189-t7mbsr25 582 29 infarctions infarction NNS cord-024189-t7mbsr25 582 30 , , , cord-024189-t7mbsr25 582 31 and and CC cord-024189-t7mbsr25 582 32 splinter splinter NN cord-024189-t7mbsr25 582 33 hemorrhages hemorrhage NNS cord-024189-t7mbsr25 582 34 . . . cord-024189-t7mbsr25 583 1 Vasculitic vasculitic JJ cord-024189-t7mbsr25 583 2 neuropathy neuropathy NN cord-024189-t7mbsr25 583 3 may may MD cord-024189-t7mbsr25 583 4 lead lead VB cord-024189-t7mbsr25 583 5 to to IN cord-024189-t7mbsr25 583 6 a a DT cord-024189-t7mbsr25 583 7 devastating devastating JJ cord-024189-t7mbsr25 583 8 mononeuritis mononeuritis NN cord-024189-t7mbsr25 583 9 multiplex multiplex NN cord-024189-t7mbsr25 583 10 or or CC cord-024189-t7mbsr25 583 11 a a DT cord-024189-t7mbsr25 583 12 disabling disable VBG cord-024189-t7mbsr25 583 13 sensory sensory JJ cord-024189-t7mbsr25 583 14 polyneuropathy polyneuropathy NNS cord-024189-t7mbsr25 583 15 . . . cord-024189-t7mbsr25 584 1 Mononeuritis mononeuritis JJ cord-024189-t7mbsr25 584 2 multiplex multiplex NN cord-024189-t7mbsr25 584 3 occurs occur VBZ cord-024189-t7mbsr25 584 4 more more RBR cord-024189-t7mbsr25 584 5 commonly commonly RB cord-024189-t7mbsr25 584 6 in in IN cord-024189-t7mbsr25 584 7 the the DT cord-024189-t7mbsr25 584 8 CSS css NN cord-024189-t7mbsr25 584 9 [ [ -LRB- cord-024189-t7mbsr25 584 10 up up IN cord-024189-t7mbsr25 584 11 to to TO cord-024189-t7mbsr25 584 12 78 78 CD cord-024189-t7mbsr25 584 13 % % NN cord-024189-t7mbsr25 584 14 of of IN cord-024189-t7mbsr25 584 15 patients patient NNS cord-024189-t7mbsr25 584 16 ( ( -LRB- cord-024189-t7mbsr25 584 17 11 11 CD cord-024189-t7mbsr25 584 18 ) ) -RRB- cord-024189-t7mbsr25 584 19 ] ] -RRB- cord-024189-t7mbsr25 585 1 and and CC cord-024189-t7mbsr25 585 2 MPA MPA NNP cord-024189-t7mbsr25 585 3 ( ( -LRB- cord-024189-t7mbsr25 585 4 up up IN cord-024189-t7mbsr25 585 5 to to TO cord-024189-t7mbsr25 585 6 58 58 CD cord-024189-t7mbsr25 585 7 % % NN cord-024189-t7mbsr25 585 8 ) ) -RRB- cord-024189-t7mbsr25 585 9 than than IN cord-024189-t7mbsr25 585 10 in in IN cord-024189-t7mbsr25 585 11 WG WG NNP cord-024189-t7mbsr25 585 12 . . . cord-024189-t7mbsr25 586 1 Central central JJ cord-024189-t7mbsr25 586 2 nervous nervous JJ cord-024189-t7mbsr25 586 3 system system NN cord-024189-t7mbsr25 586 4 abnormalities abnormality NNS cord-024189-t7mbsr25 586 5 occur occur VBP cord-024189-t7mbsr25 586 6 in in IN cord-024189-t7mbsr25 586 7 approximately approximately RB cord-024189-t7mbsr25 586 8 8 8 CD cord-024189-t7mbsr25 586 9 % % NN cord-024189-t7mbsr25 586 10 of of IN cord-024189-t7mbsr25 586 11 patients patient NNS cord-024189-t7mbsr25 586 12 with with IN cord-024189-t7mbsr25 586 13 WG WG NNP cord-024189-t7mbsr25 586 14 , , , cord-024189-t7mbsr25 586 15 usually usually RB cord-024189-t7mbsr25 586 16 in in IN cord-024189-t7mbsr25 586 17 the the DT cord-024189-t7mbsr25 586 18 form form NN cord-024189-t7mbsr25 586 19 of of IN cord-024189-t7mbsr25 586 20 cranial cranial JJ cord-024189-t7mbsr25 586 21 neuropathies neuropathy NNS cord-024189-t7mbsr25 586 22 , , , cord-024189-t7mbsr25 586 23 mass mass NN cord-024189-t7mbsr25 586 24 lesions lesion NNS cord-024189-t7mbsr25 586 25 , , , cord-024189-t7mbsr25 586 26 or or CC cord-024189-t7mbsr25 586 27 pachymeningitis pachymeningitis NN cord-024189-t7mbsr25 586 28 . . . cord-024189-t7mbsr25 587 1 The the DT cord-024189-t7mbsr25 587 2 frequency frequency NN cord-024189-t7mbsr25 587 3 of of IN cord-024189-t7mbsr25 587 4 parenchymal parenchymal NN cord-024189-t7mbsr25 587 5 brain brain NN cord-024189-t7mbsr25 587 6 involvement involvement NN cord-024189-t7mbsr25 587 7 in in IN cord-024189-t7mbsr25 587 8 AAV AAV NNP cord-024189-t7mbsr25 587 9 , , , cord-024189-t7mbsr25 587 10 though though IN cord-024189-t7mbsr25 587 11 not not RB cord-024189-t7mbsr25 587 12 yet yet RB cord-024189-t7mbsr25 587 13 known know VBN cord-024189-t7mbsr25 587 14 with with IN cord-024189-t7mbsr25 587 15 certainty certainty NN cord-024189-t7mbsr25 587 16 and and CC cord-024189-t7mbsr25 587 17 generally generally RB cord-024189-t7mbsr25 587 18 regarded regard VBN cord-024189-t7mbsr25 587 19 as as IN cord-024189-t7mbsr25 587 20 rare rare JJ cord-024189-t7mbsr25 587 21 , , , cord-024189-t7mbsr25 587 22 has have VBZ cord-024189-t7mbsr25 587 23 been be VBN cord-024189-t7mbsr25 587 24 reported report VBN cord-024189-t7mbsr25 587 25 . . . cord-024189-t7mbsr25 588 1 Central central JJ cord-024189-t7mbsr25 588 2 nervous nervous JJ cord-024189-t7mbsr25 588 3 system system NN cord-024189-t7mbsr25 588 4 disease disease NN cord-024189-t7mbsr25 588 5 generally generally RB cord-024189-t7mbsr25 588 6 occurs occur VBZ cord-024189-t7mbsr25 588 7 only only RB cord-024189-t7mbsr25 588 8 when when WRB cord-024189-t7mbsr25 588 9 more more RBR cord-024189-t7mbsr25 588 10 typical typical JJ cord-024189-t7mbsr25 588 11 disease disease NN cord-024189-t7mbsr25 588 12 manifestations manifestation NNS cord-024189-t7mbsr25 588 13 are be VBP cord-024189-t7mbsr25 588 14 present present JJ cord-024189-t7mbsr25 588 15 elsewhere elsewhere RB cord-024189-t7mbsr25 588 16 . . . cord-024189-t7mbsr25 589 1 The the DT cord-024189-t7mbsr25 589 2 CSS css NN cord-024189-t7mbsr25 589 3 is be VBZ cord-024189-t7mbsr25 589 4 the the DT cord-024189-t7mbsr25 589 5 type type NN cord-024189-t7mbsr25 589 6 of of IN cord-024189-t7mbsr25 589 7 AAV AAV NNP cord-024189-t7mbsr25 589 8 that that WDT cord-024189-t7mbsr25 589 9 is be VBZ cord-024189-t7mbsr25 589 10 most most RBS cord-024189-t7mbsr25 589 11 likely likely JJ cord-024189-t7mbsr25 589 12 to to TO cord-024189-t7mbsr25 589 13 involve involve VB cord-024189-t7mbsr25 589 14 the the DT cord-024189-t7mbsr25 589 15 heart heart NN cord-024189-t7mbsr25 589 16 , , , cord-024189-t7mbsr25 589 17 usually usually RB cord-024189-t7mbsr25 589 18 in in IN cord-024189-t7mbsr25 589 19 the the DT cord-024189-t7mbsr25 589 20 form form NN cord-024189-t7mbsr25 589 21 of of IN cord-024189-t7mbsr25 589 22 rapid rapid JJ cord-024189-t7mbsr25 589 23 - - HYPH cord-024189-t7mbsr25 589 24 onset onset NN cord-024189-t7mbsr25 589 25 heart heart NN cord-024189-t7mbsr25 589 26 failure failure NN cord-024189-t7mbsr25 589 27 . . . cord-024189-t7mbsr25 590 1 Cardiac cardiac JJ cord-024189-t7mbsr25 590 2 complications complication NNS cord-024189-t7mbsr25 590 3 in in IN cord-024189-t7mbsr25 590 4 WG WG NNP cord-024189-t7mbsr25 590 5 and and CC cord-024189-t7mbsr25 590 6 MPA MPA NNP cord-024189-t7mbsr25 590 7 are be VBP cord-024189-t7mbsr25 590 8 both both DT cord-024189-t7mbsr25 590 9 less less RBR cord-024189-t7mbsr25 590 10 common common JJ cord-024189-t7mbsr25 590 11 and and CC cord-024189-t7mbsr25 590 12 more more RBR cord-024189-t7mbsr25 590 13 diffi diffi JJ cord-024189-t7mbsr25 590 14 cult cult NN cord-024189-t7mbsr25 590 15 to to TO cord-024189-t7mbsr25 590 16 attribute attribute VB cord-024189-t7mbsr25 590 17 with with IN cord-024189-t7mbsr25 590 18 certainty certainty NN cord-024189-t7mbsr25 590 19 to to IN cord-024189-t7mbsr25 590 20 the the DT cord-024189-t7mbsr25 590 21 underlying underlie VBG cord-024189-t7mbsr25 590 22 disease disease NN cord-024189-t7mbsr25 590 23 . . . cord-024189-t7mbsr25 591 1 Focal focal JJ cord-024189-t7mbsr25 591 2 cardiac cardiac JJ cord-024189-t7mbsr25 591 3 valvular valvular JJ cord-024189-t7mbsr25 591 4 lesions lesion NNS cord-024189-t7mbsr25 591 5 , , , cord-024189-t7mbsr25 591 6 valvular valvular JJ cord-024189-t7mbsr25 591 7 insuffi insuffi NN cord-024189-t7mbsr25 591 8 ciency ciency NN cord-024189-t7mbsr25 591 9 , , , cord-024189-t7mbsr25 591 10 pericarditis pericarditis NN cord-024189-t7mbsr25 591 11 , , , cord-024189-t7mbsr25 591 12 and and CC cord-024189-t7mbsr25 591 13 coronary coronary JJ cord-024189-t7mbsr25 591 14 arteritis arteritis NN cord-024189-t7mbsr25 591 15 have have VBP cord-024189-t7mbsr25 591 16 been be VBN cord-024189-t7mbsr25 591 17 described describe VBN cord-024189-t7mbsr25 591 18 in in IN cord-024189-t7mbsr25 591 19 WG WG NNP cord-024189-t7mbsr25 591 20 . . . cord-024189-t7mbsr25 592 1 Eosinophilic eosinophilic JJ cord-024189-t7mbsr25 592 2 gastroenteritis gastroenteritis NN cord-024189-t7mbsr25 592 3 often often RB cord-024189-t7mbsr25 592 4 precedes precede VBZ cord-024189-t7mbsr25 592 5 the the DT cord-024189-t7mbsr25 592 6 frank frank JJ cord-024189-t7mbsr25 592 7 vasculitic vasculitic JJ cord-024189-t7mbsr25 592 8 phase phase NN cord-024189-t7mbsr25 592 9 of of IN cord-024189-t7mbsr25 592 10 the the DT cord-024189-t7mbsr25 592 11 CSS css NN cord-024189-t7mbsr25 592 12 . . . cord-024189-t7mbsr25 593 1 Among among IN cord-024189-t7mbsr25 593 2 patients patient NNS cord-024189-t7mbsr25 593 3 with with IN cord-024189-t7mbsr25 593 4 either either CC cord-024189-t7mbsr25 593 5 the the DT cord-024189-t7mbsr25 593 6 CSS css NN cord-024189-t7mbsr25 593 7 or or CC cord-024189-t7mbsr25 593 8 MPA MPA NNP cord-024189-t7mbsr25 593 9 , , , cord-024189-t7mbsr25 593 10 unexplained unexplained JJ cord-024189-t7mbsr25 593 11 abdominal abdominal JJ cord-024189-t7mbsr25 593 12 pain pain NN cord-024189-t7mbsr25 593 13 occurs occur VBZ cord-024189-t7mbsr25 593 14 in in IN cord-024189-t7mbsr25 593 15 up up IN cord-024189-t7mbsr25 593 16 to to TO cord-024189-t7mbsr25 593 17 one one CD cord-024189-t7mbsr25 593 18 third third NN cord-024189-t7mbsr25 593 19 of of IN cord-024189-t7mbsr25 593 20 patients patient NNS cord-024189-t7mbsr25 593 21 and and CC cord-024189-t7mbsr25 593 22 may may MD cord-024189-t7mbsr25 593 23 lead lead VB cord-024189-t7mbsr25 593 24 to to IN cord-024189-t7mbsr25 593 25 ischemic ischemic JJ cord-024189-t7mbsr25 593 26 bowel bowel NN cord-024189-t7mbsr25 593 27 . . . cord-024189-t7mbsr25 594 1 Gastrointestinal gastrointestinal JJ cord-024189-t7mbsr25 594 2 involvement involvement NN cord-024189-t7mbsr25 594 3 is be VBZ cord-024189-t7mbsr25 594 4 less less RBR cord-024189-t7mbsr25 594 5 common common JJ cord-024189-t7mbsr25 594 6 in in IN cord-024189-t7mbsr25 594 7 WG WG NNP cord-024189-t7mbsr25 594 8 . . . cord-024189-t7mbsr25 595 1 Eosinophilia Eosinophilia NNP cord-024189-t7mbsr25 595 2 ( ( -LRB- cord-024189-t7mbsr25 595 3 before before IN cord-024189-t7mbsr25 595 4 treatment treatment NN cord-024189-t7mbsr25 595 5 ) ) -RRB- cord-024189-t7mbsr25 595 6 is be VBZ cord-024189-t7mbsr25 595 7 a a DT cord-024189-t7mbsr25 595 8 sine sine FW cord-024189-t7mbsr25 595 9 qua qua FW cord-024189-t7mbsr25 595 10 non non FW cord-024189-t7mbsr25 595 11 of of IN cord-024189-t7mbsr25 595 12 the the DT cord-024189-t7mbsr25 595 13 CSS css NN cord-024189-t7mbsr25 595 14 . . . cord-024189-t7mbsr25 596 1 Eosinophil eosinophil JJ cord-024189-t7mbsr25 596 2 counts count NNS cord-024189-t7mbsr25 596 3 are be VBP cord-024189-t7mbsr25 596 4 usually usually RB cord-024189-t7mbsr25 596 5 sensitive sensitive JJ cord-024189-t7mbsr25 596 6 markers marker NNS cord-024189-t7mbsr25 596 7 of of IN cord-024189-t7mbsr25 596 8 disease disease NNP cord-024189-t7mbsr25 596 9 fl fl NNP cord-024189-t7mbsr25 596 10 ares ares NNP cord-024189-t7mbsr25 596 11 , , , cord-024189-t7mbsr25 596 12 but but CC cord-024189-t7mbsr25 596 13 respond respond VB cord-024189-t7mbsr25 596 14 very very RB cord-024189-t7mbsr25 596 15 quickly quickly RB cord-024189-t7mbsr25 596 16 ( ( -LRB- cord-024189-t7mbsr25 596 17 within within IN cord-024189-t7mbsr25 596 18 24 24 CD cord-024189-t7mbsr25 596 19 hours hour NNS cord-024189-t7mbsr25 596 20 ) ) -RRB- cord-024189-t7mbsr25 596 21 to to IN cord-024189-t7mbsr25 596 22 treatment treatment NN cord-024189-t7mbsr25 596 23 with with IN cord-024189-t7mbsr25 596 24 high high JJ cord-024189-t7mbsr25 596 25 doses dose NNS cord-024189-t7mbsr25 596 26 of of IN cord-024189-t7mbsr25 596 27 glucocorticoids glucocorticoid NNS cord-024189-t7mbsr25 596 28 . . . cord-024189-t7mbsr25 597 1 Tissue tissue NN cord-024189-t7mbsr25 597 2 infi infi NNP cord-024189-t7mbsr25 597 3 ltration ltration NN cord-024189-t7mbsr25 597 4 by by IN cord-024189-t7mbsr25 597 5 eosinophils eosinophil NNS cord-024189-t7mbsr25 597 6 , , , cord-024189-t7mbsr25 597 7 however however RB cord-024189-t7mbsr25 597 8 , , , cord-024189-t7mbsr25 597 9 may may MD cord-024189-t7mbsr25 597 10 remain remain VB cord-024189-t7mbsr25 597 11 . . . cord-024189-t7mbsr25 598 1 Mild mild JJ cord-024189-t7mbsr25 598 2 eosinophilia eosinophilia NN cord-024189-t7mbsr25 598 3 ( ( -LRB- cord-024189-t7mbsr25 598 4 rarely rarely RB cord-024189-t7mbsr25 598 5 more more JJR cord-024189-t7mbsr25 598 6 than than IN cord-024189-t7mbsr25 598 7 15 15 CD cord-024189-t7mbsr25 598 8 % % NN cord-024189-t7mbsr25 598 9 of of IN cord-024189-t7mbsr25 598 10 the the DT cord-024189-t7mbsr25 598 11 total total JJ cord-024189-t7mbsr25 598 12 white white JJ cord-024189-t7mbsr25 598 13 blood blood NN cord-024189-t7mbsr25 598 14 cell cell NN cord-024189-t7mbsr25 598 15 count count NN cord-024189-t7mbsr25 598 16 ) ) -RRB- cord-024189-t7mbsr25 598 17 may may MD cord-024189-t7mbsr25 598 18 also also RB cord-024189-t7mbsr25 598 19 occur occur VB cord-024189-t7mbsr25 598 20 in in IN cord-024189-t7mbsr25 598 21 WG WG NNP cord-024189-t7mbsr25 598 22 . . . cord-024189-t7mbsr25 599 1 Most Most JJS cord-024189-t7mbsr25 599 2 patients patient NNS cord-024189-t7mbsr25 599 3 with with IN cord-024189-t7mbsr25 599 4 CSS CSS NNP cord-024189-t7mbsr25 599 5 also also RB cord-024189-t7mbsr25 599 6 have have VBP cord-024189-t7mbsr25 599 7 elevated elevate VBN cord-024189-t7mbsr25 599 8 serum serum NN cord-024189-t7mbsr25 599 9 immunoglobulin immunoglobulin NN cord-024189-t7mbsr25 599 10 E e NN cord-024189-t7mbsr25 599 11 levels level NNS cord-024189-t7mbsr25 599 12 . . . cord-024189-t7mbsr25 600 1 In in IN cord-024189-t7mbsr25 600 2 addition addition NN cord-024189-t7mbsr25 600 3 to to IN cord-024189-t7mbsr25 600 4 ANCA ANCA NNP cord-024189-t7mbsr25 600 5 , , , cord-024189-t7mbsr25 600 6 nonspecifi nonspecifi NNP cord-024189-t7mbsr25 600 7 c c NN cord-024189-t7mbsr25 600 8 autoantibodies autoantibody NNS cord-024189-t7mbsr25 600 9 , , , cord-024189-t7mbsr25 600 10 such such JJ cord-024189-t7mbsr25 600 11 as as IN cord-024189-t7mbsr25 600 12 antinuclear antinuclear JJ cord-024189-t7mbsr25 600 13 antibodies antibody NNS cord-024189-t7mbsr25 600 14 and and CC cord-024189-t7mbsr25 600 15 rheumatoid rheumatoid NN cord-024189-t7mbsr25 600 16 factor factor NN cord-024189-t7mbsr25 600 17 , , , cord-024189-t7mbsr25 600 18 also also RB cord-024189-t7mbsr25 600 19 occur occur VBP cord-024189-t7mbsr25 600 20 in in IN cord-024189-t7mbsr25 600 21 high high JJ cord-024189-t7mbsr25 600 22 percentages percentage NNS cord-024189-t7mbsr25 600 23 of of IN cord-024189-t7mbsr25 600 24 patients patient NNS cord-024189-t7mbsr25 600 25 with with IN cord-024189-t7mbsr25 600 26 AAV AAV NNP cord-024189-t7mbsr25 600 27 . . . cord-024189-t7mbsr25 601 1 Antineutrophil Antineutrophil NNP cord-024189-t7mbsr25 601 2 cytoplasmic cytoplasmic JJ cord-024189-t7mbsr25 601 3 antibodies antibody NNS cord-024189-t7mbsr25 601 4 - - HYPH cord-024189-t7mbsr25 601 5 associated associate VBN cord-024189-t7mbsr25 601 6 vasculitides vasculitide NNS cord-024189-t7mbsr25 601 7 rarely rarely RB cord-024189-t7mbsr25 601 8 affect affect VBP cord-024189-t7mbsr25 601 9 the the DT cord-024189-t7mbsr25 601 10 parotid parotid JJ cord-024189-t7mbsr25 601 11 gland gland NN cord-024189-t7mbsr25 601 12 , , , cord-024189-t7mbsr25 601 13 pulmonary pulmonary JJ cord-024189-t7mbsr25 601 14 artery artery NN cord-024189-t7mbsr25 601 15 , , , cord-024189-t7mbsr25 601 16 breast breast NN cord-024189-t7mbsr25 601 17 , , , cord-024189-t7mbsr25 601 18 or or CC cord-024189-t7mbsr25 601 19 genitourinary genitourinary JJ cord-024189-t7mbsr25 601 20 organs organ NNS cord-024189-t7mbsr25 601 21 . . . cord-024189-t7mbsr25 602 1 Involvement involvement NN cord-024189-t7mbsr25 602 2 of of IN cord-024189-t7mbsr25 602 3 these these DT cord-024189-t7mbsr25 602 4 organs organ NNS cord-024189-t7mbsr25 602 5 by by IN cord-024189-t7mbsr25 602 6 AAV AAV NNP cord-024189-t7mbsr25 602 7 is be VBZ cord-024189-t7mbsr25 602 8 usually usually RB cord-024189-t7mbsr25 602 9 an an DT cord-024189-t7mbsr25 602 10 unexpected unexpected JJ cord-024189-t7mbsr25 602 11 fi fi NN cord-024189-t7mbsr25 602 12 nding nding NN cord-024189-t7mbsr25 602 13 on on IN cord-024189-t7mbsr25 602 14 biopsies biopsy NNS cord-024189-t7mbsr25 602 15 performed perform VBN cord-024189-t7mbsr25 602 16 to to TO cord-024189-t7mbsr25 602 17 exclude exclude VB cord-024189-t7mbsr25 602 18 other other JJ cord-024189-t7mbsr25 602 19 diseases disease NNS cord-024189-t7mbsr25 602 20 , , , cord-024189-t7mbsr25 602 21 particularly particularly RB cord-024189-t7mbsr25 602 22 cancer cancer NN cord-024189-t7mbsr25 602 23 and and CC cord-024189-t7mbsr25 602 24 infection infection NN cord-024189-t7mbsr25 602 25 . . . cord-024189-t7mbsr25 603 1 Churg Churg NNP cord-024189-t7mbsr25 603 2 - - HYPH cord-024189-t7mbsr25 603 3 Strauss Strauss NNP cord-024189-t7mbsr25 603 4 granulomas granuloma NNS cord-024189-t7mbsr25 603 5 , , , cord-024189-t7mbsr25 603 6 that that RB cord-024189-t7mbsr25 603 7 is is RB cord-024189-t7mbsr25 603 8 , , , cord-024189-t7mbsr25 603 9 cutaneous cutaneous JJ cord-024189-t7mbsr25 603 10 extravascular extravascular NNS cord-024189-t7mbsr25 603 11 necrotizing necrotize VBG cord-024189-t7mbsr25 603 12 granulomas granuloma NNS cord-024189-t7mbsr25 603 13 , , , cord-024189-t7mbsr25 603 14 occurring occur VBG cord-024189-t7mbsr25 603 15 over over IN cord-024189-t7mbsr25 603 16 the the DT cord-024189-t7mbsr25 603 17 elbow elbow NN cord-024189-t7mbsr25 603 18 . . . cord-024189-t7mbsr25 604 1 These these DT cord-024189-t7mbsr25 604 2 lesions lesion NNS cord-024189-t7mbsr25 604 3 may may MD cord-024189-t7mbsr25 604 4 occur occur VB cord-024189-t7mbsr25 604 5 in in IN cord-024189-t7mbsr25 604 6 both both CC cord-024189-t7mbsr25 604 7 the the DT cord-024189-t7mbsr25 604 8 Churg Churg NNP cord-024189-t7mbsr25 604 9 - - HYPH cord-024189-t7mbsr25 604 10 Strauss Strauss NNP cord-024189-t7mbsr25 604 11 syndrome syndrome NN cord-024189-t7mbsr25 604 12 and and CC cord-024189-t7mbsr25 604 13 Wegener Wegener NNP cord-024189-t7mbsr25 604 14 's 's POS cord-024189-t7mbsr25 604 15 granulomatosis granulomatosis NN cord-024189-t7mbsr25 604 16 , , , cord-024189-t7mbsr25 604 17 mimicking mimic VBG cord-024189-t7mbsr25 604 18 rheumatoid rheumatoid NN cord-024189-t7mbsr25 604 19 nodules nodule NNS cord-024189-t7mbsr25 604 20 . . . cord-024189-t7mbsr25 605 1 Fibrinoid Fibrinoid NNP cord-024189-t7mbsr25 605 2 necrosis necrosis NN cord-024189-t7mbsr25 605 3 , , , cord-024189-t7mbsr25 605 4 a a DT cord-024189-t7mbsr25 605 5 pathological pathological JJ cord-024189-t7mbsr25 605 6 hallmark hallmark NN cord-024189-t7mbsr25 605 7 of of IN cord-024189-t7mbsr25 605 8 AAV AAV NNP cord-024189-t7mbsr25 605 9 , , , cord-024189-t7mbsr25 605 10 may may MD cord-024189-t7mbsr25 605 11 be be VB cord-024189-t7mbsr25 605 12 found find VBN cord-024189-t7mbsr25 605 13 in in IN cord-024189-t7mbsr25 605 14 a a DT cord-024189-t7mbsr25 605 15 variety variety NN cord-024189-t7mbsr25 605 16 of of IN cord-024189-t7mbsr25 605 17 vasculitic vasculitic JJ cord-024189-t7mbsr25 605 18 ( ( -LRB- cord-024189-t7mbsr25 605 19 and and CC cord-024189-t7mbsr25 605 20 nonvasculitic nonvasculitic JJ cord-024189-t7mbsr25 605 21 ) ) -RRB- cord-024189-t7mbsr25 605 22 conditions condition NNS cord-024189-t7mbsr25 605 23 , , , cord-024189-t7mbsr25 605 24 such such JJ cord-024189-t7mbsr25 605 25 as as IN cord-024189-t7mbsr25 605 26 polyarteritis polyarteritis NN cord-024189-t7mbsr25 605 27 nodosa nodosa RB cord-024189-t7mbsr25 605 28 , , , cord-024189-t7mbsr25 605 29 scleroderma scleroderma NN cord-024189-t7mbsr25 605 30 renal renal JJ cord-024189-t7mbsr25 605 31 crisis crisis NN cord-024189-t7mbsr25 605 32 , , , cord-024189-t7mbsr25 605 33 systemic systemic JJ cord-024189-t7mbsr25 605 34 lupus lupus NN cord-024189-t7mbsr25 605 35 erythematosus erythematosus NN cord-024189-t7mbsr25 605 36 , , , cord-024189-t7mbsr25 605 37 and and CC cord-024189-t7mbsr25 605 38 malignant malignant JJ cord-024189-t7mbsr25 605 39 hypertension hypertension NN cord-024189-t7mbsr25 605 40 . . . cord-024189-t7mbsr25 606 1 Both both DT cord-024189-t7mbsr25 606 2 vasculitic vasculitic VBD cord-024189-t7mbsr25 606 3 and and CC cord-024189-t7mbsr25 606 4 necrotizing necrotize VBG cord-024189-t7mbsr25 606 5 granulomatous granulomatous JJ cord-024189-t7mbsr25 606 6 features feature NNS cord-024189-t7mbsr25 606 7 , , , cord-024189-t7mbsr25 606 8 which which WDT cord-024189-t7mbsr25 606 9 do do VBP cord-024189-t7mbsr25 606 10 not not RB cord-024189-t7mbsr25 606 11 invariably invariably RB cord-024189-t7mbsr25 606 12 coexist coexist VB cord-024189-t7mbsr25 606 13 , , , cord-024189-t7mbsr25 606 14 may may MD cord-024189-t7mbsr25 606 15 be be VB cord-024189-t7mbsr25 606 16 confi confi NNP cord-024189-t7mbsr25 606 17 rmed rmed NNP cord-024189-t7mbsr25 606 18 in in IN cord-024189-t7mbsr25 606 19 lung lung NN cord-024189-t7mbsr25 606 20 biopsy biopsy NN cord-024189-t7mbsr25 606 21 specimens specimen NNS cord-024189-t7mbsr25 606 22 . . . cord-024189-t7mbsr25 607 1 In in IN cord-024189-t7mbsr25 607 2 addition addition NN cord-024189-t7mbsr25 607 3 , , , cord-024189-t7mbsr25 607 4 pulmonary pulmonary JJ cord-024189-t7mbsr25 607 5 WG WG NNP cord-024189-t7mbsr25 607 6 frequently frequently RB cord-024189-t7mbsr25 607 7 demonstrates demonstrate VBZ cord-024189-t7mbsr25 607 8 an an DT cord-024189-t7mbsr25 607 9 extensive extensive JJ cord-024189-t7mbsr25 607 10 , , , cord-024189-t7mbsr25 607 11 nonspecifi nonspecifi NNP cord-024189-t7mbsr25 607 12 c c NN cord-024189-t7mbsr25 607 13 infl infl NNP cord-024189-t7mbsr25 607 14 ammatory ammatory NNP cord-024189-t7mbsr25 607 15 background background NNP cord-024189-t7mbsr25 607 16 . . . cord-024189-t7mbsr25 608 1 Coalescence coalescence NN cord-024189-t7mbsr25 608 2 of of IN cord-024189-t7mbsr25 608 3 such such JJ cord-024189-t7mbsr25 608 4 neutrophilic neutrophilic NNP cord-024189-t7mbsr25 608 5 microabscesses microabscesses NNP cord-024189-t7mbsr25 608 6 leads lead VBZ cord-024189-t7mbsr25 608 7 to to IN cord-024189-t7mbsr25 608 8 extensive extensive JJ cord-024189-t7mbsr25 608 9 regions region NNS cord-024189-t7mbsr25 608 10 of of IN cord-024189-t7mbsr25 608 11 " " `` cord-024189-t7mbsr25 608 12 geographic geographic JJ cord-024189-t7mbsr25 608 13 " " '' cord-024189-t7mbsr25 608 14 necrosis necrosis NN cord-024189-t7mbsr25 608 15 . . . cord-024189-t7mbsr25 609 1 Palisading palisading NN cord-024189-t7mbsr25 609 2 granulomas granuloma NNS cord-024189-t7mbsr25 609 3 , , , cord-024189-t7mbsr25 609 4 scattered scatter VBN cord-024189-t7mbsr25 609 5 giant giant JJ cord-024189-t7mbsr25 609 6 cells cell NNS cord-024189-t7mbsr25 609 7 , , , cord-024189-t7mbsr25 609 8 and and CC cord-024189-t7mbsr25 609 9 poorly poorly RB cord-024189-t7mbsr25 609 10 formed form VBN cord-024189-t7mbsr25 609 11 granulomas granuloma NNS cord-024189-t7mbsr25 609 12 may may MD cord-024189-t7mbsr25 609 13 also also RB cord-024189-t7mbsr25 609 14 be be VB cord-024189-t7mbsr25 609 15 found find VBN cord-024189-t7mbsr25 609 16 in in IN cord-024189-t7mbsr25 609 17 WG WG NNP cord-024189-t7mbsr25 609 18 . . . cord-024189-t7mbsr25 610 1 Churg Churg NNP cord-024189-t7mbsr25 610 2 - - HYPH cord-024189-t7mbsr25 610 3 Strauss Strauss NNP cord-024189-t7mbsr25 610 4 syndrome syndrome NN cord-024189-t7mbsr25 610 5 typically typically RB cord-024189-t7mbsr25 610 6 evolves evolve VBZ cord-024189-t7mbsr25 610 7 through through IN cord-024189-t7mbsr25 610 8 three three CD cord-024189-t7mbsr25 610 9 phases phase NNS cord-024189-t7mbsr25 610 10 , , , cord-024189-t7mbsr25 610 11 with with IN cord-024189-t7mbsr25 610 12 corresponding correspond VBG cord-024189-t7mbsr25 610 13 pathological pathological JJ cord-024189-t7mbsr25 610 14 fi fi NN cord-024189-t7mbsr25 610 15 ndings nding NNS cord-024189-t7mbsr25 610 16 . . . cord-024189-t7mbsr25 611 1 In in IN cord-024189-t7mbsr25 611 2 the the DT cord-024189-t7mbsr25 611 3 fi fi NN cord-024189-t7mbsr25 611 4 rst rst NN cord-024189-t7mbsr25 611 5 phase phase NN cord-024189-t7mbsr25 611 6 , , , cord-024189-t7mbsr25 611 7 allergy allergy NN cord-024189-t7mbsr25 611 8 , , , cord-024189-t7mbsr25 611 9 asthma asthma NN cord-024189-t7mbsr25 611 10 , , , cord-024189-t7mbsr25 611 11 and and CC cord-024189-t7mbsr25 611 12 other other JJ cord-024189-t7mbsr25 611 13 atopic atopic JJ cord-024189-t7mbsr25 611 14 symptoms symptom NNS cord-024189-t7mbsr25 611 15 predominate predominate VBP cord-024189-t7mbsr25 611 16 . . . cord-024189-t7mbsr25 612 1 In in IN cord-024189-t7mbsr25 612 2 the the DT cord-024189-t7mbsr25 612 3 second second JJ cord-024189-t7mbsr25 612 4 , , , cord-024189-t7mbsr25 612 5 eosinophilic eosinophilic JJ cord-024189-t7mbsr25 612 6 infi infi NNP cord-024189-t7mbsr25 612 7 ltration ltration NN cord-024189-t7mbsr25 612 8 occurs occur VBZ cord-024189-t7mbsr25 612 9 in in IN cord-024189-t7mbsr25 612 10 the the DT cord-024189-t7mbsr25 612 11 lung lung NN cord-024189-t7mbsr25 612 12 and and CC cord-024189-t7mbsr25 612 13 other other JJ cord-024189-t7mbsr25 612 14 organs organ NNS cord-024189-t7mbsr25 612 15 ( ( -LRB- cord-024189-t7mbsr25 612 16 eosinophilic eosinophilic JJ cord-024189-t7mbsr25 612 17 pneumonia pneumonia NN cord-024189-t7mbsr25 612 18 , , , cord-024189-t7mbsr25 612 19 eosinophilic eosinophilic JJ cord-024189-t7mbsr25 612 20 gastroenteritis gastroenteritis NN cord-024189-t7mbsr25 612 21 ; ; : cord-024189-t7mbsr25 612 22 Figure figure NN cord-024189-t7mbsr25 612 23 21C 21c CD cord-024189-t7mbsr25 612 24 -5 -5 NNP cord-024189-t7mbsr25 612 25 ) ) -RRB- cord-024189-t7mbsr25 612 26 . . . cord-024189-t7mbsr25 613 1 In in IN cord-024189-t7mbsr25 613 2 the the DT cord-024189-t7mbsr25 613 3 third third JJ cord-024189-t7mbsr25 613 4 phase phase NN cord-024189-t7mbsr25 613 5 , , , cord-024189-t7mbsr25 613 6 vasculitis vasculitis NN cord-024189-t7mbsr25 613 7 ensues ensue VBZ cord-024189-t7mbsr25 613 8 . . . cord-024189-t7mbsr25 614 1 Curiously curiously RB cord-024189-t7mbsr25 614 2 , , , cord-024189-t7mbsr25 614 3 at at IN cord-024189-t7mbsr25 614 4 the the DT cord-024189-t7mbsr25 614 5 time time NN cord-024189-t7mbsr25 614 6 the the DT cord-024189-t7mbsr25 614 7 vasculitic vasculitic JJ cord-024189-t7mbsr25 614 8 phase phase NN cord-024189-t7mbsr25 614 9 begins begin VBZ cord-024189-t7mbsr25 614 10 , , , cord-024189-t7mbsr25 614 11 patients patient NNS cord-024189-t7mbsr25 614 12 ' ' POS cord-024189-t7mbsr25 614 13 asthma asthma NN cord-024189-t7mbsr25 614 14 often often RB cord-024189-t7mbsr25 614 15 improves improve VBZ cord-024189-t7mbsr25 614 16 signifi signifi NNP cord-024189-t7mbsr25 614 17 cantly cantly NNP cord-024189-t7mbsr25 614 18 . . . cord-024189-t7mbsr25 615 1 The the DT cord-024189-t7mbsr25 615 2 histopathological histopathological JJ cord-024189-t7mbsr25 615 3 fi fi NNP cord-024189-t7mbsr25 615 4 ndings nding NNS cord-024189-t7mbsr25 615 5 in in IN cord-024189-t7mbsr25 615 6 CSS css NN cord-024189-t7mbsr25 615 7 in in IN cord-024189-t7mbsr25 615 8 the the DT cord-024189-t7mbsr25 615 9 lung lung NN cord-024189-t7mbsr25 615 10 include include VBP cord-024189-t7mbsr25 615 11 eosinophilic eosinophilic JJ cord-024189-t7mbsr25 615 12 infi infi NNP cord-024189-t7mbsr25 615 13 ltrates ltrates NNP cord-024189-t7mbsr25 615 14 ; ; : cord-024189-t7mbsr25 615 15 extensive extensive JJ cord-024189-t7mbsr25 615 16 areas area NNS cord-024189-t7mbsr25 615 17 of of IN cord-024189-t7mbsr25 615 18 necrosis necrosis NN cord-024189-t7mbsr25 615 19 ( ( -LRB- cord-024189-t7mbsr25 615 20 reminiscent reminiscent JJ cord-024189-t7mbsr25 615 21 of of IN cord-024189-t7mbsr25 615 22 the the DT cord-024189-t7mbsr25 615 23 geographic geographic JJ cord-024189-t7mbsr25 615 24 necrosis necrosis NN cord-024189-t7mbsr25 615 25 in in IN cord-024189-t7mbsr25 615 26 WG WG NNP cord-024189-t7mbsr25 615 27 ) ) -RRB- cord-024189-t7mbsr25 615 28 ; ; : cord-024189-t7mbsr25 615 29 a a DT cord-024189-t7mbsr25 615 30 granulomatous granulomatous JJ cord-024189-t7mbsr25 615 31 vasculitis vasculitis NN cord-024189-t7mbsr25 615 32 of of IN cord-024189-t7mbsr25 615 33 small small JJ cord-024189-t7mbsr25 615 34 arteries artery NNS cord-024189-t7mbsr25 615 35 and and CC cord-024189-t7mbsr25 615 36 veins vein NNS cord-024189-t7mbsr25 615 37 , , , cord-024189-t7mbsr25 615 38 associated associate VBN cord-024189-t7mbsr25 615 39 with with IN cord-024189-t7mbsr25 615 40 striking strike VBG cord-024189-t7mbsr25 615 41 eosinophilic eosinophilic JJ cord-024189-t7mbsr25 615 42 infi infi NNP cord-024189-t7mbsr25 615 43 ltration ltration NN cord-024189-t7mbsr25 615 44 . . . cord-024189-t7mbsr25 616 1 In in IN cord-024189-t7mbsr25 616 2 contrast contrast NN cord-024189-t7mbsr25 616 3 to to IN cord-024189-t7mbsr25 616 4 WG WG NNP cord-024189-t7mbsr25 616 5 and and CC cord-024189-t7mbsr25 616 6 MPA MPA NNP cord-024189-t7mbsr25 616 7 , , , cord-024189-t7mbsr25 616 8 lymphadenopathy lymphadenopathy JJ cord-024189-t7mbsr25 616 9 ( ( -LRB- cord-024189-t7mbsr25 616 10 with with IN cord-024189-t7mbsr25 616 11 overwhelming overwhelming JJ cord-024189-t7mbsr25 616 12 eosinophilic eosinophilic JJ cord-024189-t7mbsr25 616 13 infi infi NNP cord-024189-t7mbsr25 616 14 ltration ltration NN cord-024189-t7mbsr25 616 15 into into IN cord-024189-t7mbsr25 616 16 the the DT cord-024189-t7mbsr25 616 17 lymph lymph NN cord-024189-t7mbsr25 616 18 nodes node NNS cord-024189-t7mbsr25 616 19 ) ) -RRB- cord-024189-t7mbsr25 616 20 , , , cord-024189-t7mbsr25 616 21 is be VBZ cord-024189-t7mbsr25 616 22 frequently frequently RB cord-024189-t7mbsr25 616 23 found find VBN cord-024189-t7mbsr25 616 24 in in IN cord-024189-t7mbsr25 616 25 CSS css NN cord-024189-t7mbsr25 616 26 . . . cord-024189-t7mbsr25 617 1 The the DT cord-024189-t7mbsr25 617 2 interstitial interstitial JJ cord-024189-t7mbsr25 617 3 lung lung NN cord-024189-t7mbsr25 617 4 disease disease NN cord-024189-t7mbsr25 617 5 of of IN cord-024189-t7mbsr25 617 6 MPA MPA NNP cord-024189-t7mbsr25 617 7 resembles resemble VBZ cord-024189-t7mbsr25 617 8 usual usual JJ cord-024189-t7mbsr25 617 9 interstitial interstitial JJ cord-024189-t7mbsr25 617 10 pneumonitis pneumonitis NN cord-024189-t7mbsr25 617 11 ( ( -LRB- cord-024189-t7mbsr25 617 12 UIP UIP NNP cord-024189-t7mbsr25 617 13 ) ) -RRB- cord-024189-t7mbsr25 617 14 , , , cord-024189-t7mbsr25 617 15 with with IN cord-024189-t7mbsr25 617 16 the the DT cord-024189-t7mbsr25 617 17 exception exception NN cord-024189-t7mbsr25 617 18 that that DT cord-024189-t7mbsr25 617 19 necrosis necrosis NN cord-024189-t7mbsr25 617 20 of of IN cord-024189-t7mbsr25 617 21 the the DT cord-024189-t7mbsr25 617 22 alveolar alveolar JJ cord-024189-t7mbsr25 617 23 septae septae NN cord-024189-t7mbsr25 617 24 and and CC cord-024189-t7mbsr25 617 25 areas area NNS cord-024189-t7mbsr25 617 26 of of IN cord-024189-t7mbsr25 617 27 hemorrhage hemorrhage NN cord-024189-t7mbsr25 617 28 can can MD cord-024189-t7mbsr25 617 29 occur occur VB cord-024189-t7mbsr25 617 30 . . . cord-024189-t7mbsr25 618 1 More more RBR cord-024189-t7mbsr25 618 2 characteristic characteristic JJ cord-024189-t7mbsr25 618 3 fi fi NN cord-024189-t7mbsr25 618 4 ndings nding NNS cord-024189-t7mbsr25 618 5 in in IN cord-024189-t7mbsr25 618 6 MPA MPA NNP cord-024189-t7mbsr25 618 7 , , , cord-024189-t7mbsr25 618 8 however however RB cord-024189-t7mbsr25 618 9 , , , cord-024189-t7mbsr25 618 10 reveal reveal VB cord-024189-t7mbsr25 618 11 nonspecifi nonspecifi NNP cord-024189-t7mbsr25 618 12 c c NNP cord-024189-t7mbsr25 618 13 infi infi NNP cord-024189-t7mbsr25 618 14 ltrates ltrates NNP cord-024189-t7mbsr25 618 15 or or CC cord-024189-t7mbsr25 618 16 alveolar alveolar JJ cord-024189-t7mbsr25 618 17 hemorrhage hemorrhage NN cord-024189-t7mbsr25 618 18 . . . cord-024189-t7mbsr25 619 1 Vasculitis vasculitis NN cord-024189-t7mbsr25 619 2 of of IN cord-024189-t7mbsr25 619 3 the the DT cord-024189-t7mbsr25 619 4 pulmonary pulmonary JJ cord-024189-t7mbsr25 619 5 capillaries capillary NNS cord-024189-t7mbsr25 619 6 may may MD cord-024189-t7mbsr25 619 7 be be VB cord-024189-t7mbsr25 619 8 diffi diffi JJ cord-024189-t7mbsr25 619 9 cult cult NN cord-024189-t7mbsr25 619 10 to to TO cord-024189-t7mbsr25 619 11 prove prove VB cord-024189-t7mbsr25 619 12 . . . cord-024189-t7mbsr25 620 1 Renal renal JJ cord-024189-t7mbsr25 620 2 disease disease NN cord-024189-t7mbsr25 620 3 in in IN cord-024189-t7mbsr25 620 4 the the DT cord-024189-t7mbsr25 620 5 AAVs aav NNS cord-024189-t7mbsr25 620 6 is be VBZ cord-024189-t7mbsr25 620 7 associated associate VBN cord-024189-t7mbsr25 620 8 with with IN cord-024189-t7mbsr25 620 9 focal focal JJ cord-024189-t7mbsr25 620 10 , , , cord-024189-t7mbsr25 620 11 segmental segmental JJ cord-024189-t7mbsr25 620 12 lysis lysis NN cord-024189-t7mbsr25 620 13 of of IN cord-024189-t7mbsr25 620 14 glomerular glomerular JJ cord-024189-t7mbsr25 620 15 tufts tuft NNS cord-024189-t7mbsr25 620 16 , , , cord-024189-t7mbsr25 620 17 disruption disruption NN cord-024189-t7mbsr25 620 18 of of IN cord-024189-t7mbsr25 620 19 the the DT cord-024189-t7mbsr25 620 20 basement basement NN cord-024189-t7mbsr25 620 21 membrane membrane NN cord-024189-t7mbsr25 620 22 , , , cord-024189-t7mbsr25 620 23 and and CC cord-024189-t7mbsr25 620 24 accumulation accumulation NN cord-024189-t7mbsr25 620 25 of of IN cord-024189-t7mbsr25 620 26 fi fi NN cord-024189-t7mbsr25 620 27 brinoid brinoid NNP cord-024189-t7mbsr25 620 28 material material NN cord-024189-t7mbsr25 620 29 ( ( -LRB- cord-024189-t7mbsr25 620 30 i.e. i.e. FW cord-024189-t7mbsr25 620 31 , , , cord-024189-t7mbsr25 620 32 fi fi NN cord-024189-t7mbsr25 620 33 brinoid brinoid NNP cord-024189-t7mbsr25 620 34 necrosis necrosis NN cord-024189-t7mbsr25 620 35 ) ) -RRB- cord-024189-t7mbsr25 620 36 . . . cord-024189-t7mbsr25 621 1 Crescents crescent NNS cord-024189-t7mbsr25 621 2 in in IN cord-024189-t7mbsr25 621 3 Bowman Bowman NNP cord-024189-t7mbsr25 621 4 's 's POS cord-024189-t7mbsr25 621 5 space space NN cord-024189-t7mbsr25 621 6 develop develop VBP cord-024189-t7mbsr25 621 7 as as IN cord-024189-t7mbsr25 621 8 a a DT cord-024189-t7mbsr25 621 9 result result NN cord-024189-t7mbsr25 621 10 of of IN cord-024189-t7mbsr25 621 11 spillage spillage NN cord-024189-t7mbsr25 621 12 of of IN cord-024189-t7mbsr25 621 13 infl infl NNP cord-024189-t7mbsr25 621 14 ammatory ammatory NNP cord-024189-t7mbsr25 621 15 mediators mediator NNS cord-024189-t7mbsr25 621 16 across across IN cord-024189-t7mbsr25 621 17 the the DT cord-024189-t7mbsr25 621 18 ruptured ruptured JJ cord-024189-t7mbsr25 621 19 glomerular glomerular JJ cord-024189-t7mbsr25 621 20 capillaries capillary NNS cord-024189-t7mbsr25 621 21 , , , cord-024189-t7mbsr25 621 22 accumulation accumulation NN cord-024189-t7mbsr25 621 23 of of IN cord-024189-t7mbsr25 621 24 macrophages macrophage NNS cord-024189-t7mbsr25 621 25 , , , cord-024189-t7mbsr25 621 26 and and CC cord-024189-t7mbsr25 621 27 epithelial epithelial JJ cord-024189-t7mbsr25 621 28 cell cell NN cord-024189-t7mbsr25 621 29 proliferation proliferation NN cord-024189-t7mbsr25 621 30 . . . cord-024189-t7mbsr25 622 1 Thrombotic thrombotic JJ cord-024189-t7mbsr25 622 2 changes change NNS cord-024189-t7mbsr25 622 3 in in IN cord-024189-t7mbsr25 622 4 the the DT cord-024189-t7mbsr25 622 5 glomerular glomerular JJ cord-024189-t7mbsr25 622 6 capillary capillary JJ cord-024189-t7mbsr25 622 7 loops loop NNS cord-024189-t7mbsr25 622 8 are be VBP cord-024189-t7mbsr25 622 9 among among IN cord-024189-t7mbsr25 622 10 the the DT cord-024189-t7mbsr25 622 11 earliest early JJS cord-024189-t7mbsr25 622 12 histologic histologic JJ cord-024189-t7mbsr25 622 13 changes change NNS cord-024189-t7mbsr25 622 14 . . . cord-024189-t7mbsr25 623 1 Acute acute JJ cord-024189-t7mbsr25 623 2 tubular tubular JJ cord-024189-t7mbsr25 623 3 necrosis necrosis NN cord-024189-t7mbsr25 623 4 and and CC cord-024189-t7mbsr25 623 5 tubulointerstitial tubulointerstitial JJ cord-024189-t7mbsr25 623 6 nephritis nephritis NN cord-024189-t7mbsr25 623 7 are be VBP cord-024189-t7mbsr25 623 8 also also RB cord-024189-t7mbsr25 623 9 seen see VBN cord-024189-t7mbsr25 623 10 commonly commonly RB cord-024189-t7mbsr25 623 11 . . . cord-024189-t7mbsr25 624 1 Immunofl Immunofl NNP cord-024189-t7mbsr25 624 2 uorescence uorescence NN cord-024189-t7mbsr25 624 3 studies study NNS cord-024189-t7mbsr25 624 4 of of IN cord-024189-t7mbsr25 624 5 renal renal JJ cord-024189-t7mbsr25 624 6 biopsy biopsy NN cord-024189-t7mbsr25 624 7 specimens specimen NNS cord-024189-t7mbsr25 624 8 demonstrate demonstrate VBP cord-024189-t7mbsr25 624 9 scant scant JJ cord-024189-t7mbsr25 624 10 deposition deposition NN cord-024189-t7mbsr25 624 11 of of IN cord-024189-t7mbsr25 624 12 immunoglobulin immunoglobulin NN cord-024189-t7mbsr25 624 13 and and CC cord-024189-t7mbsr25 624 14 complement complement NN cord-024189-t7mbsr25 624 15 , , , cord-024189-t7mbsr25 624 16 hence hence RB cord-024189-t7mbsr25 624 17 the the DT cord-024189-t7mbsr25 624 18 term term NN cord-024189-t7mbsr25 624 19 pauci pauci NN cord-024189-t7mbsr25 624 20 - - HYPH cord-024189-t7mbsr25 624 21 immune immune JJ cord-024189-t7mbsr25 624 22 glomerulonephritis glomerulonephritis NN cord-024189-t7mbsr25 624 23 . . . cord-024189-t7mbsr25 625 1 Tissue tissue NN cord-024189-t7mbsr25 625 2 samples sample NNS cord-024189-t7mbsr25 625 3 from from IN cord-024189-t7mbsr25 625 4 involved involved JJ cord-024189-t7mbsr25 625 5 areas area NNS cord-024189-t7mbsr25 625 6 of of IN cord-024189-t7mbsr25 625 7 the the DT cord-024189-t7mbsr25 625 8 upper upper JJ cord-024189-t7mbsr25 625 9 respiratory respiratory JJ cord-024189-t7mbsr25 625 10 tract tract NN cord-024189-t7mbsr25 625 11 ( ( -LRB- cord-024189-t7mbsr25 625 12 nose nose NN cord-024189-t7mbsr25 625 13 , , , cord-024189-t7mbsr25 625 14 sinuses sinus NNS cord-024189-t7mbsr25 625 15 , , , cord-024189-t7mbsr25 625 16 and and CC cord-024189-t7mbsr25 625 17 subglottic subglottic JJ cord-024189-t7mbsr25 625 18 region region NN cord-024189-t7mbsr25 625 19 ) ) -RRB- cord-024189-t7mbsr25 625 20 in in IN cord-024189-t7mbsr25 625 21 WG WG NNP cord-024189-t7mbsr25 625 22 often often RB cord-024189-t7mbsr25 625 23 reveal reveal VBP cord-024189-t7mbsr25 625 24 only only RB cord-024189-t7mbsr25 625 25 acute acute JJ cord-024189-t7mbsr25 625 26 and and CC cord-024189-t7mbsr25 625 27 chronic chronic JJ cord-024189-t7mbsr25 625 28 infl infl NN cord-024189-t7mbsr25 625 29 ammation ammation NN cord-024189-t7mbsr25 625 30 . . . cord-024189-t7mbsr25 626 1 Nevertheless nevertheless RB cord-024189-t7mbsr25 626 2 , , , cord-024189-t7mbsr25 626 3 these these DT cord-024189-t7mbsr25 626 4 biopsies biopsy NNS cord-024189-t7mbsr25 626 5 are be VBP cord-024189-t7mbsr25 626 6 easier easy JJR cord-024189-t7mbsr25 626 7 to to TO cord-024189-t7mbsr25 626 8 obtain obtain VB cord-024189-t7mbsr25 626 9 than than IN cord-024189-t7mbsr25 626 10 are be VBP cord-024189-t7mbsr25 626 11 biopsies biopsy NNS cord-024189-t7mbsr25 626 12 of of IN cord-024189-t7mbsr25 626 13 the the DT cord-024189-t7mbsr25 626 14 lung lung NN cord-024189-t7mbsr25 626 15 and and CC cord-024189-t7mbsr25 626 16 kidney kidney NN cord-024189-t7mbsr25 626 17 . . . cord-024189-t7mbsr25 627 1 Moreover moreover RB cord-024189-t7mbsr25 627 2 , , , cord-024189-t7mbsr25 627 3 the the DT cord-024189-t7mbsr25 627 4 combination combination NN cord-024189-t7mbsr25 627 5 of of IN cord-024189-t7mbsr25 627 6 these these DT cord-024189-t7mbsr25 627 7 pathological pathological JJ cord-024189-t7mbsr25 627 8 fi fi NN cord-024189-t7mbsr25 627 9 ndings nding NNS cord-024189-t7mbsr25 627 10 ( ( -LRB- cord-024189-t7mbsr25 627 11 nondiagnostic nondiagnostic JJ cord-024189-t7mbsr25 627 12 in in IN cord-024189-t7mbsr25 627 13 and and CC cord-024189-t7mbsr25 627 14 of of IN cord-024189-t7mbsr25 627 15 themselves -PRON- PRP cord-024189-t7mbsr25 627 16 ) ) -RRB- cord-024189-t7mbsr25 627 17 and and CC cord-024189-t7mbsr25 627 18 compatible compatible JJ cord-024189-t7mbsr25 627 19 clinical clinical JJ cord-024189-t7mbsr25 627 20 features feature NNS cord-024189-t7mbsr25 627 21 ( ( -LRB- cord-024189-t7mbsr25 627 22 e.g. e.g. RB cord-024189-t7mbsr25 627 23 , , , cord-024189-t7mbsr25 627 24 pulmonary pulmonary JJ cord-024189-t7mbsr25 627 25 nodules nodule NNS cord-024189-t7mbsr25 627 26 and and CC cord-024189-t7mbsr25 627 27 PR3-ANCA PR3-ANCA NNP cord-024189-t7mbsr25 627 28 ) ) -RRB- cord-024189-t7mbsr25 627 29 may may MD cord-024189-t7mbsr25 627 30 yield yield VB cord-024189-t7mbsr25 627 31 the the DT cord-024189-t7mbsr25 627 32 diagnosis diagnosis NN cord-024189-t7mbsr25 627 33 in in IN cord-024189-t7mbsr25 627 34 some some DT cord-024189-t7mbsr25 627 35 cases case NNS cord-024189-t7mbsr25 627 36 . . . cord-024189-t7mbsr25 628 1 Upper upper JJ cord-024189-t7mbsr25 628 2 respiratory respiratory JJ cord-024189-t7mbsr25 628 3 tract tract NN cord-024189-t7mbsr25 628 4 biopsies biopsy NNS cord-024189-t7mbsr25 628 5 are be VBP cord-024189-t7mbsr25 628 6 therefore therefore RB cord-024189-t7mbsr25 628 7 worth worth JJ cord-024189-t7mbsr25 628 8 undertaking undertaking NN cord-024189-t7mbsr25 628 9 in in IN cord-024189-t7mbsr25 628 10 patients patient NNS cord-024189-t7mbsr25 628 11 with with IN cord-024189-t7mbsr25 628 12 significant significant JJ cord-024189-t7mbsr25 628 13 upper upper JJ cord-024189-t7mbsr25 628 14 respiratory respiratory JJ cord-024189-t7mbsr25 628 15 involvement involvement NN cord-024189-t7mbsr25 628 16 . . . cord-024189-t7mbsr25 629 1 Eosinophilic eosinophilic JJ cord-024189-t7mbsr25 629 2 infi infi NNP cord-024189-t7mbsr25 629 3 ltration ltration NN cord-024189-t7mbsr25 629 4 of of IN cord-024189-t7mbsr25 629 5 a a DT cord-024189-t7mbsr25 629 6 salivary salivary JJ cord-024189-t7mbsr25 629 7 gland gland NN cord-024189-t7mbsr25 629 8 in in IN cord-024189-t7mbsr25 629 9 a a DT cord-024189-t7mbsr25 629 10 patient patient NN cord-024189-t7mbsr25 629 11 with with IN cord-024189-t7mbsr25 629 12 the the DT cord-024189-t7mbsr25 629 13 Churg Churg NNP cord-024189-t7mbsr25 629 14 - - HYPH cord-024189-t7mbsr25 629 15 Strauss Strauss NNP cord-024189-t7mbsr25 629 16 syndrome syndrome NN cord-024189-t7mbsr25 629 17 . . . cord-024189-t7mbsr25 630 1 The the DT cord-024189-t7mbsr25 630 2 arrows arrow NNS cord-024189-t7mbsr25 630 3 in in IN cord-024189-t7mbsr25 630 4 panel panel NN cord-024189-t7mbsr25 630 5 B B NNP cord-024189-t7mbsr25 630 6 indicate indicate VB cord-024189-t7mbsr25 630 7 the the DT cord-024189-t7mbsr25 630 8 formation formation NN cord-024189-t7mbsr25 630 9 of of IN cord-024189-t7mbsr25 630 10 a a DT cord-024189-t7mbsr25 630 11 Churg Churg NNP cord-024189-t7mbsr25 630 12 - - HYPH cord-024189-t7mbsr25 630 13 Strauss Strauss NNP cord-024189-t7mbsr25 630 14 granuloma granuloma NN cord-024189-t7mbsr25 630 15 , , , cord-024189-t7mbsr25 630 16 with with IN cord-024189-t7mbsr25 630 17 multinucleated multinucleated JJ cord-024189-t7mbsr25 630 18 giant giant JJ cord-024189-t7mbsr25 630 19 cells cell NNS cord-024189-t7mbsr25 630 20 , , , cord-024189-t7mbsr25 630 21 palisading palisade VBG cord-024189-t7mbsr25 630 22 histiocytes histiocyte NNS cord-024189-t7mbsr25 630 23 , , , cord-024189-t7mbsr25 630 24 and and CC cord-024189-t7mbsr25 630 25 scattered scatter VBD cord-024189-t7mbsr25 630 26 eosinophils eosinophil NNS cord-024189-t7mbsr25 630 27 . . . cord-024189-t7mbsr25 631 1 Proteinase-3 Proteinase-3 NNP cord-024189-t7mbsr25 631 2 , , , cord-024189-t7mbsr25 631 3 a a DT cord-024189-t7mbsr25 631 4 29-kDa 29-kda CD cord-024189-t7mbsr25 631 5 serine serine NN cord-024189-t7mbsr25 631 6 protease protease NN cord-024189-t7mbsr25 631 7 , , , cord-024189-t7mbsr25 631 8 is be VBZ cord-024189-t7mbsr25 631 9 found find VBN cord-024189-t7mbsr25 631 10 in in IN cord-024189-t7mbsr25 631 11 the the DT cord-024189-t7mbsr25 631 12 azurophilic azurophilic JJ cord-024189-t7mbsr25 631 13 granules granule NNS cord-024189-t7mbsr25 631 14 of of IN cord-024189-t7mbsr25 631 15 neutrophils neutrophil NNS cord-024189-t7mbsr25 631 16 and and CC cord-024189-t7mbsr25 631 17 peroxidase peroxidase NN cord-024189-t7mbsr25 631 18 - - HYPH cord-024189-t7mbsr25 631 19 positive positive JJ cord-024189-t7mbsr25 631 20 lysosomes lysosome NNS cord-024189-t7mbsr25 631 21 of of IN cord-024189-t7mbsr25 631 22 monocytes monocyte NNS cord-024189-t7mbsr25 631 23 . . . cord-024189-t7mbsr25 632 1 MPO MPO NNP cord-024189-t7mbsr25 632 2 , , , cord-024189-t7mbsr25 632 3 which which WDT cord-024189-t7mbsr25 632 4 constitutes constitute VBZ cord-024189-t7mbsr25 632 5 nearly nearly RB cord-024189-t7mbsr25 632 6 5 5 CD cord-024189-t7mbsr25 632 7 % % NN cord-024189-t7mbsr25 632 8 of of IN cord-024189-t7mbsr25 632 9 the the DT cord-024189-t7mbsr25 632 10 total total JJ cord-024189-t7mbsr25 632 11 protein protein NN cord-024189-t7mbsr25 632 12 content content NN cord-024189-t7mbsr25 632 13 of of IN cord-024189-t7mbsr25 632 14 the the DT cord-024189-t7mbsr25 632 15 neutrophil neutrophil NN cord-024189-t7mbsr25 632 16 , , , cord-024189-t7mbsr25 632 17 is be VBZ cord-024189-t7mbsr25 632 18 localized localize VBN cord-024189-t7mbsr25 632 19 to to IN cord-024189-t7mbsr25 632 20 the the DT cord-024189-t7mbsr25 632 21 same same JJ cord-024189-t7mbsr25 632 22 cellular cellular JJ cord-024189-t7mbsr25 632 23 compartments compartment NNS cord-024189-t7mbsr25 632 24 as as IN cord-024189-t7mbsr25 632 25 PR3 PR3 NNP cord-024189-t7mbsr25 632 26 . . . cord-024189-t7mbsr25 633 1 The the DT cord-024189-t7mbsr25 633 2 protein protein NN cord-024189-t7mbsr25 633 3 is be VBZ cord-024189-t7mbsr25 633 4 a a DT cord-024189-t7mbsr25 633 5 covalently covalently RB cord-024189-t7mbsr25 633 6 linked link VBN cord-024189-t7mbsr25 633 7 dimer dimer NN cord-024189-t7mbsr25 633 8 with with IN cord-024189-t7mbsr25 633 9 a a DT cord-024189-t7mbsr25 633 10 molecular molecular JJ cord-024189-t7mbsr25 633 11 weight weight NN cord-024189-t7mbsr25 633 12 of of IN cord-024189-t7mbsr25 633 13 140 140 CD cord-024189-t7mbsr25 633 14 kDa kDa NNS cord-024189-t7mbsr25 633 15 . . . cord-024189-t7mbsr25 634 1 The the DT cord-024189-t7mbsr25 634 2 autoantibodies autoantibody NNS cord-024189-t7mbsr25 634 3 directed direct VBD cord-024189-t7mbsr25 634 4 against against IN cord-024189-t7mbsr25 634 5 PR3 PR3 NNP cord-024189-t7mbsr25 634 6 and and CC cord-024189-t7mbsr25 634 7 MPO MPO NNP cord-024189-t7mbsr25 634 8 are be VBP cord-024189-t7mbsr25 634 9 directed direct VBN cord-024189-t7mbsr25 634 10 against against IN cord-024189-t7mbsr25 634 11 multiple multiple JJ cord-024189-t7mbsr25 634 12 epitopes epitope NNS cord-024189-t7mbsr25 634 13 . . . cord-024189-t7mbsr25 635 1 Sera Sera NNP cord-024189-t7mbsr25 635 2 from from IN cord-024189-t7mbsr25 635 3 different different JJ cord-024189-t7mbsr25 635 4 patients patient NNS cord-024189-t7mbsr25 635 5 may may MD cord-024189-t7mbsr25 635 6 recognize recognize VB cord-024189-t7mbsr25 635 7 different different JJ cord-024189-t7mbsr25 635 8 epitopes epitope NNS cord-024189-t7mbsr25 635 9 . . . cord-024189-t7mbsr25 636 1 All all DT cord-024189-t7mbsr25 636 2 ANCA ANCA NNP cord-024189-t7mbsr25 636 3 , , , cord-024189-t7mbsr25 636 4 however however RB cord-024189-t7mbsr25 636 5 , , , cord-024189-t7mbsr25 636 6 recognize recognize VB cord-024189-t7mbsr25 636 7 restricted restricted JJ cord-024189-t7mbsr25 636 8 epitopes epitope NNS cord-024189-t7mbsr25 636 9 of of IN cord-024189-t7mbsr25 636 10 PR3 PR3 NNP cord-024189-t7mbsr25 636 11 involving involve VBG cord-024189-t7mbsr25 636 12 its -PRON- PRP$ cord-024189-t7mbsr25 636 13 catalytic catalytic JJ cord-024189-t7mbsr25 636 14 site site NN cord-024189-t7mbsr25 636 15 . . . cord-024189-t7mbsr25 637 1 Two two CD cord-024189-t7mbsr25 637 2 types type NNS cord-024189-t7mbsr25 637 3 of of IN cord-024189-t7mbsr25 637 4 assays assay NNS cord-024189-t7mbsr25 637 5 for for IN cord-024189-t7mbsr25 637 6 ANCA ANCA NNP cord-024189-t7mbsr25 637 7 - - HYPH cord-024189-t7mbsr25 637 8 immunofl immunofl NN cord-024189-t7mbsr25 637 9 uorescence uorescence NN cord-024189-t7mbsr25 637 10 and and CC cord-024189-t7mbsr25 637 11 enzyme enzyme NN cord-024189-t7mbsr25 637 12 immunoassay immunoassay NN cord-024189-t7mbsr25 637 13 - - : cord-024189-t7mbsr25 637 14 are be VBP cord-024189-t7mbsr25 637 15 now now RB cord-024189-t7mbsr25 637 16 in in IN cord-024189-t7mbsr25 637 17 common common JJ cord-024189-t7mbsr25 637 18 use use NN cord-024189-t7mbsr25 637 19 . . . cord-024189-t7mbsr25 638 1 Capture capture NN cord-024189-t7mbsr25 638 2 enzyme enzyme NN cord-024189-t7mbsr25 638 3 immunoassays immunoassay NNS cord-024189-t7mbsr25 638 4 may may MD cord-024189-t7mbsr25 638 5 offer offer VB cord-024189-t7mbsr25 638 6 some some DT cord-024189-t7mbsr25 638 7 advantages advantage NNS cord-024189-t7mbsr25 638 8 over over IN cord-024189-t7mbsr25 638 9 the the DT cord-024189-t7mbsr25 638 10 more more RBR cord-024189-t7mbsr25 638 11 widely widely RB cord-024189-t7mbsr25 638 12 available available JJ cord-024189-t7mbsr25 638 13 tests test NNS cord-024189-t7mbsr25 638 14 , , , cord-024189-t7mbsr25 638 15 but but CC cord-024189-t7mbsr25 638 16 are be VBP cord-024189-t7mbsr25 638 17 currently currently RB cord-024189-t7mbsr25 638 18 performed perform VBN cord-024189-t7mbsr25 638 19 only only RB cord-024189-t7mbsr25 638 20 in in IN cord-024189-t7mbsr25 638 21 specialty specialty NN cord-024189-t7mbsr25 638 22 centers center NNS cord-024189-t7mbsr25 638 23 . . . cord-024189-t7mbsr25 639 1 With with IN cord-024189-t7mbsr25 639 2 immunofl immunofl NN cord-024189-t7mbsr25 639 3 uorescence uorescence NN cord-024189-t7mbsr25 639 4 , , , cord-024189-t7mbsr25 639 5 three three CD cord-024189-t7mbsr25 639 6 principal principal JJ cord-024189-t7mbsr25 639 7 patterns pattern NNS cord-024189-t7mbsr25 639 8 of of IN cord-024189-t7mbsr25 639 9 fl fl NNP cord-024189-t7mbsr25 639 10 uorescence uorescence NN cord-024189-t7mbsr25 639 11 are be VBP cord-024189-t7mbsr25 639 12 recognized recognize VBN cord-024189-t7mbsr25 639 13 : : : cord-024189-t7mbsr25 639 14 the the DT cord-024189-t7mbsr25 639 15 cytoplasmic cytoplasmic JJ cord-024189-t7mbsr25 639 16 ( ( -LRB- cord-024189-t7mbsr25 639 17 C C NNP cord-024189-t7mbsr25 639 18 - - HYPH cord-024189-t7mbsr25 639 19 ANCA ANCA NNP cord-024189-t7mbsr25 639 20 ) ) -RRB- cord-024189-t7mbsr25 639 21 , , , cord-024189-t7mbsr25 639 22 perinuclear perinuclear NNP cord-024189-t7mbsr25 639 23 ( ( -LRB- cord-024189-t7mbsr25 639 24 P P NNP cord-024189-t7mbsr25 639 25 - - HYPH cord-024189-t7mbsr25 639 26 ANCA ANCA NNP cord-024189-t7mbsr25 639 27 ) ) -RRB- cord-024189-t7mbsr25 639 28 , , , cord-024189-t7mbsr25 639 29 and and CC cord-024189-t7mbsr25 639 30 " " `` cord-024189-t7mbsr25 639 31 atypical atypical JJ cord-024189-t7mbsr25 639 32 " " '' cord-024189-t7mbsr25 639 33 patterns pattern NNS cord-024189-t7mbsr25 639 34 . . . cord-024189-t7mbsr25 640 1 In in IN cord-024189-t7mbsr25 640 2 patients patient NNS cord-024189-t7mbsr25 640 3 with with IN cord-024189-t7mbsr25 640 4 vasculitis vasculitis NN cord-024189-t7mbsr25 640 5 , , , cord-024189-t7mbsr25 640 6 the the DT cord-024189-t7mbsr25 640 7 C C NNP cord-024189-t7mbsr25 640 8 - - HYPH cord-024189-t7mbsr25 640 9 ANCA ANCA NNP cord-024189-t7mbsr25 640 10 pattern pattern NN cord-024189-t7mbsr25 640 11 usually usually RB cord-024189-t7mbsr25 640 12 corresponds correspond VBZ cord-024189-t7mbsr25 640 13 to to IN cord-024189-t7mbsr25 640 14 the the DT cord-024189-t7mbsr25 640 15 detection detection NN cord-024189-t7mbsr25 640 16 of of IN cord-024189-t7mbsr25 640 17 PR3-ANCA PR3-ANCA NNP cord-024189-t7mbsr25 640 18 by by IN cord-024189-t7mbsr25 640 19 enzyme enzyme NN cord-024189-t7mbsr25 640 20 immunoassay immunoassay NN cord-024189-t7mbsr25 640 21 . . . cord-024189-t7mbsr25 641 1 The the DT cord-024189-t7mbsr25 641 2 combination combination NN cord-024189-t7mbsr25 641 3 of of IN cord-024189-t7mbsr25 641 4 a a DT cord-024189-t7mbsr25 641 5 C C NNP cord-024189-t7mbsr25 641 6 - - HYPH cord-024189-t7mbsr25 641 7 ANCA ANCA NNP cord-024189-t7mbsr25 641 8 pattern pattern NN cord-024189-t7mbsr25 641 9 on on IN cord-024189-t7mbsr25 641 10 immunofl immunofl NN cord-024189-t7mbsr25 641 11 uorescence uorescence NN cord-024189-t7mbsr25 641 12 testing testing NN cord-024189-t7mbsr25 641 13 and and CC cord-024189-t7mbsr25 641 14 PR3-ANCA PR3-ANCA NNP cord-024189-t7mbsr25 641 15 is be VBZ cord-024189-t7mbsr25 641 16 associated associate VBN cord-024189-t7mbsr25 641 17 most most RBS cord-024189-t7mbsr25 641 18 strongly strongly RB cord-024189-t7mbsr25 641 19 with with IN cord-024189-t7mbsr25 641 20 WG WG NNP cord-024189-t7mbsr25 641 21 . . . cord-024189-t7mbsr25 642 1 The the DT cord-024189-t7mbsr25 642 2 P P NNP cord-024189-t7mbsr25 642 3 - - HYPH cord-024189-t7mbsr25 642 4 ANCA ANCA NNP cord-024189-t7mbsr25 642 5 pattern pattern NN cord-024189-t7mbsr25 642 6 , , , cord-024189-t7mbsr25 642 7 which which WDT cord-024189-t7mbsr25 642 8 usually usually RB cord-024189-t7mbsr25 642 9 corresponds correspond VBZ cord-024189-t7mbsr25 642 10 to to IN cord-024189-t7mbsr25 642 11 the the DT cord-024189-t7mbsr25 642 12 presence presence NN cord-024189-t7mbsr25 642 13 of of IN cord-024189-t7mbsr25 642 14 MPO MPO NNP cord-024189-t7mbsr25 642 15 - - HYPH cord-024189-t7mbsr25 642 16 ANCA ANCA NNP cord-024189-t7mbsr25 642 17 in in IN cord-024189-t7mbsr25 642 18 vasculitis vasculitis JJ cord-024189-t7mbsr25 642 19 patients patient NNS cord-024189-t7mbsr25 642 20 , , , cord-024189-t7mbsr25 642 21 occurs occur VBZ cord-024189-t7mbsr25 642 22 in in IN cord-024189-t7mbsr25 642 23 approximately approximately RB cord-024189-t7mbsr25 642 24 10 10 CD cord-024189-t7mbsr25 642 25 % % NN cord-024189-t7mbsr25 642 26 of of IN cord-024189-t7mbsr25 642 27 patients patient NNS cord-024189-t7mbsr25 642 28 with with IN cord-024189-t7mbsr25 642 29 WG WG NNP cord-024189-t7mbsr25 642 30 , , , cord-024189-t7mbsr25 642 31 but but CC cord-024189-t7mbsr25 642 32 is be VBZ cord-024189-t7mbsr25 642 33 more more RBR cord-024189-t7mbsr25 642 34 typical typical JJ cord-024189-t7mbsr25 642 35 of of IN cord-024189-t7mbsr25 642 36 MPA MPA NNP cord-024189-t7mbsr25 642 37 , , , cord-024189-t7mbsr25 642 38 the the DT cord-024189-t7mbsr25 642 39 CSS css NN cord-024189-t7mbsr25 642 40 , , , cord-024189-t7mbsr25 642 41 and and CC cord-024189-t7mbsr25 642 42 renal renal JJ cord-024189-t7mbsr25 642 43 - - HYPH cord-024189-t7mbsr25 642 44 limited limited JJ cord-024189-t7mbsr25 642 45 vasculitis vasculitis NN cord-024189-t7mbsr25 642 46 . . . cord-024189-t7mbsr25 643 1 The the DT cord-024189-t7mbsr25 643 2 great great JJ cord-024189-t7mbsr25 643 3 majority majority NN cord-024189-t7mbsr25 643 4 of of IN cord-024189-t7mbsr25 643 5 patients patient NNS cord-024189-t7mbsr25 643 6 with with IN cord-024189-t7mbsr25 643 7 drug drug NN cord-024189-t7mbsr25 643 8 - - HYPH cord-024189-t7mbsr25 643 9 induced induce VBN cord-024189-t7mbsr25 643 10 AAVs aav NNS cord-024189-t7mbsr25 643 11 are be VBP cord-024189-t7mbsr25 643 12 P p NN cord-024189-t7mbsr25 643 13 - - HYPH cord-024189-t7mbsr25 643 14 ANCA ANCA NNP cord-024189-t7mbsr25 643 15 positive positive JJ cord-024189-t7mbsr25 643 16 , , , cord-024189-t7mbsr25 643 17 often often RB cord-024189-t7mbsr25 643 18 with with IN cord-024189-t7mbsr25 643 19 very very RB cord-024189-t7mbsr25 643 20 high high JJ cord-024189-t7mbsr25 643 21 titers titer NNS cord-024189-t7mbsr25 643 22 of of IN cord-024189-t7mbsr25 643 23 MPO MPO NNP cord-024189-t7mbsr25 643 24 - - HYPH cord-024189-t7mbsr25 643 25 ANCA ANCA NNP cord-024189-t7mbsr25 643 26 . . . cord-024189-t7mbsr25 644 1 Regardless regardless RB cord-024189-t7mbsr25 644 2 of of IN cord-024189-t7mbsr25 644 3 the the DT cord-024189-t7mbsr25 644 4 immunofl immunofl NNP cord-024189-t7mbsr25 644 5 uorescence uorescence NNP cord-024189-t7mbsr25 644 6 pattern pattern NN cord-024189-t7mbsr25 644 7 , , , cord-024189-t7mbsr25 644 8 positive positive JJ cord-024189-t7mbsr25 644 9 immunofl immunofl NN cord-024189-t7mbsr25 644 10 uorescence uorescence NN cord-024189-t7mbsr25 644 11 assays assay NNS cord-024189-t7mbsr25 644 12 should should MD cord-024189-t7mbsr25 644 13 be be VB cord-024189-t7mbsr25 644 14 confi confi VBN cord-024189-t7mbsr25 644 15 rmed rme VBN cord-024189-t7mbsr25 644 16 by by IN cord-024189-t7mbsr25 644 17 the the DT cord-024189-t7mbsr25 644 18 performance performance NN cord-024189-t7mbsr25 644 19 of of IN cord-024189-t7mbsr25 644 20 enzyme enzyme NN cord-024189-t7mbsr25 644 21 immunoassays immunoassays NNP cord-024189-t7mbsr25 644 22 for for IN cord-024189-t7mbsr25 644 23 the the DT cord-024189-t7mbsr25 644 24 specifi specifi NNP cord-024189-t7mbsr25 644 25 c c NN cord-024189-t7mbsr25 644 26 antibodies antibody NNS cord-024189-t7mbsr25 644 27 associated associate VBN cord-024189-t7mbsr25 644 28 with with IN cord-024189-t7mbsr25 644 29 vasculitis vasculitis NN cord-024189-t7mbsr25 644 30 : : : cord-024189-t7mbsr25 644 31 PR3-and PR3-and NNP cord-024189-t7mbsr25 644 32 MPO MPO NNP cord-024189-t7mbsr25 644 33 - - HYPH cord-024189-t7mbsr25 644 34 ANCA ANCA NNP cord-024189-t7mbsr25 644 35 . . . cord-024189-t7mbsr25 645 1 Even even RB cord-024189-t7mbsr25 645 2 for for IN cord-024189-t7mbsr25 645 3 C C NNP cord-024189-t7mbsr25 645 4 - - HYPH cord-024189-t7mbsr25 645 5 ANCA ANCA NNP cord-024189-t7mbsr25 645 6 , , , cord-024189-t7mbsr25 645 7 the the DT cord-024189-t7mbsr25 645 8 positive positive JJ cord-024189-t7mbsr25 645 9 predictive predictive JJ cord-024189-t7mbsr25 645 10 value value NN cord-024189-t7mbsr25 645 11 for for IN cord-024189-t7mbsr25 645 12 WG WG NNP cord-024189-t7mbsr25 645 13 is be VBZ cord-024189-t7mbsr25 645 14 only only RB cord-024189-t7mbsr25 645 15 in in IN cord-024189-t7mbsr25 645 16 the the DT cord-024189-t7mbsr25 645 17 range range NN cord-024189-t7mbsr25 645 18 of of IN cord-024189-t7mbsr25 645 19 45 45 CD cord-024189-t7mbsr25 645 20 % % NN cord-024189-t7mbsr25 645 21 to to TO cord-024189-t7mbsr25 645 22 50 50 CD cord-024189-t7mbsr25 645 23 % % NN cord-024189-t7mbsr25 645 24 ( ( -LRB- cord-024189-t7mbsr25 645 25 12 12 CD cord-024189-t7mbsr25 645 26 , , , cord-024189-t7mbsr25 645 27 13 13 CD cord-024189-t7mbsr25 645 28 ) ) -RRB- cord-024189-t7mbsr25 645 29 . . . cord-024189-t7mbsr25 646 1 Despite despite IN cord-024189-t7mbsr25 646 2 advances advance NNS cord-024189-t7mbsr25 646 3 in in IN cord-024189-t7mbsr25 646 4 ANCA ANCA NNP cord-024189-t7mbsr25 646 5 testing testing NN cord-024189-t7mbsr25 646 6 techniques technique NNS cord-024189-t7mbsr25 646 7 , , , cord-024189-t7mbsr25 646 8 the the DT cord-024189-t7mbsr25 646 9 cornerstone cornerstone NN cord-024189-t7mbsr25 646 10 of of IN cord-024189-t7mbsr25 646 11 diagnosis diagnosis NN cord-024189-t7mbsr25 646 12 in in IN cord-024189-t7mbsr25 646 13 WG WG NNP cord-024189-t7mbsr25 646 14 remains remain VBZ cord-024189-t7mbsr25 646 15 the the DT cord-024189-t7mbsr25 646 16 rigorous rigorous JJ cord-024189-t7mbsr25 646 17 interpretation interpretation NN cord-024189-t7mbsr25 646 18 of of IN cord-024189-t7mbsr25 646 19 histopathological histopathological JJ cord-024189-t7mbsr25 646 20 specimens specimen NNS cord-024189-t7mbsr25 646 21 within within IN cord-024189-t7mbsr25 646 22 the the DT cord-024189-t7mbsr25 646 23 overall overall JJ cord-024189-t7mbsr25 646 24 clinical clinical JJ cord-024189-t7mbsr25 646 25 context context NN cord-024189-t7mbsr25 646 26 . . . cord-024189-t7mbsr25 647 1 When when WRB cord-024189-t7mbsr25 647 2 biopsy biopsy NN cord-024189-t7mbsr25 647 3 specimens specimen NNS cord-024189-t7mbsr25 647 4 are be VBP cord-024189-t7mbsr25 647 5 nondiagnostic nondiagnostic JJ cord-024189-t7mbsr25 647 6 , , , cord-024189-t7mbsr25 647 7 ANCA ANCA NNP cord-024189-t7mbsr25 647 8 assays assay NNS cord-024189-t7mbsr25 647 9 provide provide VBP cord-024189-t7mbsr25 647 10 an an DT cord-024189-t7mbsr25 647 11 important important JJ cord-024189-t7mbsr25 647 12 adjunct adjunct NN cord-024189-t7mbsr25 647 13 to to IN cord-024189-t7mbsr25 647 14 diagnosis diagnosis NN cord-024189-t7mbsr25 647 15 ( ( -LRB- cord-024189-t7mbsr25 647 16 Table table NN cord-024189-t7mbsr25 647 17 21C-4 21c-4 CD cord-024189-t7mbsr25 647 18 ) ) -RRB- cord-024189-t7mbsr25 647 19 . . . cord-024189-t7mbsr25 648 1 In in IN cord-024189-t7mbsr25 648 2 the the DT cord-024189-t7mbsr25 648 3 proper proper JJ cord-024189-t7mbsr25 648 4 clinical clinical JJ cord-024189-t7mbsr25 648 5 setting setting NN cord-024189-t7mbsr25 648 6 , , , cord-024189-t7mbsr25 648 7 a a DT cord-024189-t7mbsr25 648 8 positive positive JJ cord-024189-t7mbsr25 648 9 ANCA ANCA NNP cord-024189-t7mbsr25 648 10 assay assay NN cord-024189-t7mbsr25 648 11 greatly greatly RB cord-024189-t7mbsr25 648 12 increases increase VBZ cord-024189-t7mbsr25 648 13 the the DT cord-024189-t7mbsr25 648 14 likelihood likelihood NN cord-024189-t7mbsr25 648 15 that that IN cord-024189-t7mbsr25 648 16 a a DT cord-024189-t7mbsr25 648 17 form form NN cord-024189-t7mbsr25 648 18 of of IN cord-024189-t7mbsr25 648 19 AAV AAV NNP cord-024189-t7mbsr25 648 20 is be VBZ cord-024189-t7mbsr25 648 21 present present JJ cord-024189-t7mbsr25 648 22 . . . cord-024189-t7mbsr25 649 1 Most Most JJS cord-024189-t7mbsr25 649 2 series serie NNS cord-024189-t7mbsr25 649 3 indicate indicate VBP cord-024189-t7mbsr25 649 4 that that IN cord-024189-t7mbsr25 649 5 up up IN cord-024189-t7mbsr25 649 6 to to TO cord-024189-t7mbsr25 649 7 10 10 CD cord-024189-t7mbsr25 649 8 % % NN cord-024189-t7mbsr25 649 9 to to TO cord-024189-t7mbsr25 649 10 20 20 CD cord-024189-t7mbsr25 649 11 % % NN cord-024189-t7mbsr25 649 12 of of IN cord-024189-t7mbsr25 649 13 patients patient NNS cord-024189-t7mbsr25 649 14 with with IN cord-024189-t7mbsr25 649 15 active active JJ cord-024189-t7mbsr25 649 16 , , , cord-024189-t7mbsr25 649 17 untreated untreated JJ cord-024189-t7mbsr25 649 18 WG WG NNP cord-024189-t7mbsr25 649 19 are be VBP cord-024189-t7mbsr25 649 20 ANCA ANCA NNP cord-024189-t7mbsr25 649 21 negative negative JJ cord-024189-t7mbsr25 649 22 . . . cord-024189-t7mbsr25 650 1 For for IN cord-024189-t7mbsr25 650 2 patients patient NNS cord-024189-t7mbsr25 650 3 with with IN cord-024189-t7mbsr25 650 4 limited limited JJ cord-024189-t7mbsr25 650 5 WG WG NNP cord-024189-t7mbsr25 650 6 , , , cord-024189-t7mbsr25 650 7 30 30 CD cord-024189-t7mbsr25 650 8 % % NN cord-024189-t7mbsr25 650 9 or or CC cord-024189-t7mbsr25 650 10 more more JJR cord-024189-t7mbsr25 650 11 of of IN cord-024189-t7mbsr25 650 12 patients patient NNS cord-024189-t7mbsr25 650 13 lack lack VBP cord-024189-t7mbsr25 650 14 ANCA ANCA NNP cord-024189-t7mbsr25 650 15 . . . cord-024189-t7mbsr25 651 1 Approximately approximately RB cord-024189-t7mbsr25 651 2 70 70 CD cord-024189-t7mbsr25 651 3 % % NN cord-024189-t7mbsr25 651 4 of of IN cord-024189-t7mbsr25 651 5 patients patient NNS cord-024189-t7mbsr25 651 6 with with IN cord-024189-t7mbsr25 651 7 MPA MPA NNP cord-024189-t7mbsr25 651 8 and and CC cord-024189-t7mbsr25 651 9 50 50 CD cord-024189-t7mbsr25 651 10 % % NN cord-024189-t7mbsr25 651 11 of of IN cord-024189-t7mbsr25 651 12 those those DT cord-024189-t7mbsr25 651 13 with with IN cord-024189-t7mbsr25 651 14 CSS css NN cord-024189-t7mbsr25 651 15 ( ( -LRB- cord-024189-t7mbsr25 651 16 higher high JJR cord-024189-t7mbsr25 651 17 in in IN cord-024189-t7mbsr25 651 18 some some DT cord-024189-t7mbsr25 651 19 series series NN cord-024189-t7mbsr25 651 20 ) ) -RRB- cord-024189-t7mbsr25 651 21 have have VBP cord-024189-t7mbsr25 651 22 ANCA ANCA NNP cord-024189-t7mbsr25 651 23 . . . cord-024189-t7mbsr25 652 1 Positive positive JJ cord-024189-t7mbsr25 652 2 ANCA ANCA NNP cord-024189-t7mbsr25 652 3 serologies serology NNS cord-024189-t7mbsr25 652 4 are be VBP cord-024189-t7mbsr25 652 5 extremely extremely RB cord-024189-t7mbsr25 652 6 useful useful JJ cord-024189-t7mbsr25 652 7 in in IN cord-024189-t7mbsr25 652 8 suggesting suggest VBG cord-024189-t7mbsr25 652 9 the the DT cord-024189-t7mbsr25 652 10 diagnosis diagnosis NN cord-024189-t7mbsr25 652 11 in in IN cord-024189-t7mbsr25 652 12 the the DT cord-024189-t7mbsr25 652 13 proper proper JJ cord-024189-t7mbsr25 652 14 clinical clinical JJ cord-024189-t7mbsr25 652 15 setting setting NN cord-024189-t7mbsr25 652 16 . . . cord-024189-t7mbsr25 653 1 Positive positive JJ cord-024189-t7mbsr25 653 2 immunofl immunofl NN cord-024189-t7mbsr25 653 3 uorescence uorescence NN cord-024189-t7mbsr25 653 4 assays assay NNS cord-024189-t7mbsr25 653 5 without without IN cord-024189-t7mbsr25 653 6 confi confi NNP cord-024189-t7mbsr25 653 7 rmatory rmatory NNP cord-024189-t7mbsr25 653 8 enzyme enzyme NNP cord-024189-t7mbsr25 653 9 immunoassays immunoassays NNP cord-024189-t7mbsr25 653 10 for for IN cord-024189-t7mbsr25 653 11 anti anti JJ cord-024189-t7mbsr25 653 12 - - JJ cord-024189-t7mbsr25 653 13 PR3 pr3 JJ cord-024189-t7mbsr25 653 14 or or CC cord-024189-t7mbsr25 653 15 anti anti JJ cord-024189-t7mbsr25 653 16 - - JJ cord-024189-t7mbsr25 653 17 MPO MPO NNP cord-024189-t7mbsr25 653 18 antibodies antibody NNS cord-024189-t7mbsr25 653 19 are be VBP cord-024189-t7mbsr25 653 20 of of IN cord-024189-t7mbsr25 653 21 limited limited JJ cord-024189-t7mbsr25 653 22 utility utility NN cord-024189-t7mbsr25 653 23 . . . cord-024189-t7mbsr25 654 1 Histopathology Histopathology NNP cord-024189-t7mbsr25 654 2 remains remain VBZ cord-024189-t7mbsr25 654 3 the the DT cord-024189-t7mbsr25 654 4 gold gold NN cord-024189-t7mbsr25 654 5 standard standard NN cord-024189-t7mbsr25 654 6 for for IN cord-024189-t7mbsr25 654 7 diagnosis diagnosis NN cord-024189-t7mbsr25 654 8 in in IN cord-024189-t7mbsr25 654 9 most most JJS cord-024189-t7mbsr25 654 10 cases case NNS cord-024189-t7mbsr25 654 11 . . . cord-024189-t7mbsr25 655 1 Negative negative JJ cord-024189-t7mbsr25 655 2 ANCA ANCA NNP cord-024189-t7mbsr25 655 3 assays assay NNS cord-024189-t7mbsr25 655 4 do do VBP cord-024189-t7mbsr25 655 5 not not RB cord-024189-t7mbsr25 655 6 exclude exclude VB cord-024189-t7mbsr25 655 7 ANCA ANCA NNP cord-024189-t7mbsr25 655 8 - - HYPH cord-024189-t7mbsr25 655 9 associated associate VBN cord-024189-t7mbsr25 655 10 vasculitis vasculitis NN cord-024189-t7mbsr25 655 11 because because IN cord-024189-t7mbsr25 655 12 between between IN cord-024189-t7mbsr25 655 13 10 10 CD cord-024189-t7mbsr25 655 14 % % NN cord-024189-t7mbsr25 655 15 and and CC cord-024189-t7mbsr25 655 16 50 50 CD cord-024189-t7mbsr25 655 17 % % NN cord-024189-t7mbsr25 655 18 of of IN cord-024189-t7mbsr25 655 19 patients patient NNS cord-024189-t7mbsr25 655 20 with with IN cord-024189-t7mbsr25 655 21 ANCA ANCA NNP cord-024189-t7mbsr25 655 22 - - HYPH cord-024189-t7mbsr25 655 23 associated associate VBN cord-024189-t7mbsr25 655 24 vasculitis vasculitis NN cord-024189-t7mbsr25 655 25 ( ( -LRB- cord-024189-t7mbsr25 655 26 depending depend VBG cord-024189-t7mbsr25 655 27 on on IN cord-024189-t7mbsr25 655 28 the the DT cord-024189-t7mbsr25 655 29 particular particular JJ cord-024189-t7mbsr25 655 30 disease disease NN cord-024189-t7mbsr25 655 31 ) ) -RRB- cord-024189-t7mbsr25 655 32 may may MD cord-024189-t7mbsr25 655 33 be be VB cord-024189-t7mbsr25 655 34 ANCA ANCA NNP cord-024189-t7mbsr25 655 35 - - HYPH cord-024189-t7mbsr25 655 36 negative negative JJ cord-024189-t7mbsr25 655 37 . . . cord-024189-t7mbsr25 656 1 Persistence persistence NN cord-024189-t7mbsr25 656 2 of of IN cord-024189-t7mbsr25 656 3 ANCA ANCA NNP cord-024189-t7mbsr25 656 4 in in IN cord-024189-t7mbsr25 656 5 the the DT cord-024189-t7mbsr25 656 6 absence absence NN cord-024189-t7mbsr25 656 7 of of IN cord-024189-t7mbsr25 656 8 clinical clinical JJ cord-024189-t7mbsr25 656 9 indications indication NNS cord-024189-t7mbsr25 656 10 of of IN cord-024189-t7mbsr25 656 11 active active JJ cord-024189-t7mbsr25 656 12 disease disease NN cord-024189-t7mbsr25 656 13 does do VBZ cord-024189-t7mbsr25 656 14 not not RB cord-024189-t7mbsr25 656 15 indicate indicate VB cord-024189-t7mbsr25 656 16 a a DT cord-024189-t7mbsr25 656 17 need need NN cord-024189-t7mbsr25 656 18 for for IN cord-024189-t7mbsr25 656 19 continued continued JJ cord-024189-t7mbsr25 656 20 treatment treatment NN cord-024189-t7mbsr25 656 21 . . . cord-024189-t7mbsr25 657 1 In in IN cord-024189-t7mbsr25 657 2 a a DT cord-024189-t7mbsr25 657 3 patient patient NN cord-024189-t7mbsr25 657 4 who who WP cord-024189-t7mbsr25 657 5 was be VBD cord-024189-t7mbsr25 657 6 ANCA ANCA NNP cord-024189-t7mbsr25 657 7 - - HYPH cord-024189-t7mbsr25 657 8 positive positive JJ cord-024189-t7mbsr25 657 9 during during IN cord-024189-t7mbsr25 657 10 active active JJ cord-024189-t7mbsr25 657 11 disease disease NN cord-024189-t7mbsr25 657 12 , , , cord-024189-t7mbsr25 657 13 persistent persistent JJ cord-024189-t7mbsr25 657 14 ANCA ANCA NNP cord-024189-t7mbsr25 657 15 - - HYPH cord-024189-t7mbsr25 657 16 negativity negativity NN cord-024189-t7mbsr25 657 17 provides provide VBZ cord-024189-t7mbsr25 657 18 reassurance reassurance NN cord-024189-t7mbsr25 657 19 - - : cord-024189-t7mbsr25 657 20 but but CC cord-024189-t7mbsr25 657 21 no no DT cord-024189-t7mbsr25 657 22 guarantee guarantee NN cord-024189-t7mbsr25 657 23 - - : cord-024189-t7mbsr25 657 24 that that IN cord-024189-t7mbsr25 657 25 the the DT cord-024189-t7mbsr25 657 26 disease disease NN cord-024189-t7mbsr25 657 27 is be VBZ cord-024189-t7mbsr25 657 28 not not RB cord-024189-t7mbsr25 657 29 active active JJ cord-024189-t7mbsr25 657 30 . . . cord-024189-t7mbsr25 658 1 If if IN cord-024189-t7mbsr25 658 2 disease disease NNP cord-024189-t7mbsr25 658 3 fl fl NNP cord-024189-t7mbsr25 658 4 ares ares NNP cord-024189-t7mbsr25 658 5 occur occur VBP cord-024189-t7mbsr25 658 6 in in IN cord-024189-t7mbsr25 658 7 such such JJ cord-024189-t7mbsr25 658 8 patients patient NNS cord-024189-t7mbsr25 658 9 , , , cord-024189-t7mbsr25 658 10 they -PRON- PRP cord-024189-t7mbsr25 658 11 are be VBP cord-024189-t7mbsr25 658 12 usually usually RB cord-024189-t7mbsr25 658 13 limited limited JJ cord-024189-t7mbsr25 658 14 . . . cord-024189-t7mbsr25 659 1 A a DT cord-024189-t7mbsr25 659 2 patient patient NN cord-024189-t7mbsr25 659 3 who who WP cord-024189-t7mbsr25 659 4 becomes become VBZ cord-024189-t7mbsr25 659 5 ANCA ANCA NNP cord-024189-t7mbsr25 659 6 - - HYPH cord-024189-t7mbsr25 659 7 positive positive JJ cord-024189-t7mbsr25 659 8 again again RB cord-024189-t7mbsr25 659 9 following follow VBG cord-024189-t7mbsr25 659 10 a a DT cord-024189-t7mbsr25 659 11 period period NN cord-024189-t7mbsr25 659 12 of of IN cord-024189-t7mbsr25 659 13 clinical clinical JJ cord-024189-t7mbsr25 659 14 quiescence quiescence NN cord-024189-t7mbsr25 659 15 associated associate VBN cord-024189-t7mbsr25 659 16 with with IN cord-024189-t7mbsr25 659 17 negative negative JJ cord-024189-t7mbsr25 659 18 ANCA ANCA NNP cord-024189-t7mbsr25 659 19 assays assay NNS cord-024189-t7mbsr25 659 20 may may MD cord-024189-t7mbsr25 659 21 be be VB cord-024189-t7mbsr25 659 22 at at IN cord-024189-t7mbsr25 659 23 an an DT cord-024189-t7mbsr25 659 24 increased increase VBN cord-024189-t7mbsr25 659 25 risk risk NN cord-024189-t7mbsr25 659 26 for for IN cord-024189-t7mbsr25 659 27 a a DT cord-024189-t7mbsr25 659 28 disease disease NN cord-024189-t7mbsr25 659 29 fl fl NNP cord-024189-t7mbsr25 659 30 are be VBP cord-024189-t7mbsr25 659 31 . . . cord-024189-t7mbsr25 660 1 The the DT cord-024189-t7mbsr25 660 2 temporal temporal JJ cord-024189-t7mbsr25 660 3 correlation correlation NN cord-024189-t7mbsr25 660 4 between between IN cord-024189-t7mbsr25 660 5 the the DT cord-024189-t7mbsr25 660 6 return return NN cord-024189-t7mbsr25 660 7 of of IN cord-024189-t7mbsr25 660 8 ANCA ANCA NNP cord-024189-t7mbsr25 660 9 and and CC cord-024189-t7mbsr25 660 10 a a DT cord-024189-t7mbsr25 660 11 disease disease NN cord-024189-t7mbsr25 660 12 fl fl NNP cord-024189-t7mbsr25 660 13 are be VBP cord-024189-t7mbsr25 660 14 , , , cord-024189-t7mbsr25 660 15 however however RB cord-024189-t7mbsr25 660 16 , , , cord-024189-t7mbsr25 660 17 is be VBZ cord-024189-t7mbsr25 660 18 poor poor JJ cord-024189-t7mbsr25 660 19 . . . cord-024189-t7mbsr25 661 1 Treatment treatment NN cord-024189-t7mbsr25 661 2 of of IN cord-024189-t7mbsr25 661 3 ANCA ANCA NNP cord-024189-t7mbsr25 661 4 - - HYPH cord-024189-t7mbsr25 661 5 associated associate VBN cord-024189-t7mbsr25 661 6 vasculitis vasculitis NN cord-024189-t7mbsr25 661 7 should should MD cord-024189-t7mbsr25 661 8 never never RB cord-024189-t7mbsr25 661 9 be be VB cord-024189-t7mbsr25 661 10 predicated predicate VBN cord-024189-t7mbsr25 661 11 upon upon IN cord-024189-t7mbsr25 661 12 ANCA ANCA NNP cord-024189-t7mbsr25 661 13 serologies serology NNS cord-024189-t7mbsr25 661 14 or or CC cord-024189-t7mbsr25 661 15 titers titer NNS cord-024189-t7mbsr25 661 16 alone alone RB cord-024189-t7mbsr25 661 17 . . . cord-024189-t7mbsr25 662 1 ABBREVIATIONS abbreviation NNS cord-024189-t7mbsr25 662 2 : : : cord-024189-t7mbsr25 663 1 ANCA ANCA NNP cord-024189-t7mbsr25 663 2 , , , cord-024189-t7mbsr25 663 3 antineutrophil antineutrophil NNP cord-024189-t7mbsr25 663 4 cytoplasmic cytoplasmic JJ cord-024189-t7mbsr25 663 5 antibody antibody NN cord-024189-t7mbsr25 663 6 ; ; : cord-024189-t7mbsr25 663 7 MPO MPO NNP cord-024189-t7mbsr25 663 8 , , , cord-024189-t7mbsr25 663 9 myeloperoxidase myeloperoxidase NNP cord-024189-t7mbsr25 663 10 ; ; : cord-024189-t7mbsr25 663 11 PR3 PR3 NNP cord-024189-t7mbsr25 663 12 , , , cord-024189-t7mbsr25 663 13 proteinase proteinase NN cord-024189-t7mbsr25 663 14 3 3 CD cord-024189-t7mbsr25 663 15 . . . cord-024189-t7mbsr25 664 1 In in IN cord-024189-t7mbsr25 664 2 general general JJ cord-024189-t7mbsr25 664 3 , , , cord-024189-t7mbsr25 664 4 ANCA ANCA NNP cord-024189-t7mbsr25 664 5 titers titer NNS cord-024189-t7mbsr25 664 6 have have VBP cord-024189-t7mbsr25 664 7 imperfect imperfect JJ cord-024189-t7mbsr25 664 8 correlations correlation NNS cord-024189-t7mbsr25 664 9 with with IN cord-024189-t7mbsr25 664 10 disease disease NN cord-024189-t7mbsr25 664 11 activity activity NN cord-024189-t7mbsr25 664 12 . . . cord-024189-t7mbsr25 665 1 In in IN cord-024189-t7mbsr25 665 2 one one CD cord-024189-t7mbsr25 665 3 study study NN cord-024189-t7mbsr25 665 4 , , , cord-024189-t7mbsr25 665 5 the the DT cord-024189-t7mbsr25 665 6 positive positive JJ cord-024189-t7mbsr25 665 7 predictive predictive JJ cord-024189-t7mbsr25 665 8 value value NN cord-024189-t7mbsr25 665 9 of of IN cord-024189-t7mbsr25 665 10 a a DT cord-024189-t7mbsr25 665 11 rise rise NN cord-024189-t7mbsr25 665 12 in in IN cord-024189-t7mbsr25 665 13 ANCA ANCA NNP cord-024189-t7mbsr25 665 14 titers titer NNS cord-024189-t7mbsr25 665 15 as as IN cord-024189-t7mbsr25 665 16 measured measure VBN cord-024189-t7mbsr25 665 17 by by IN cord-024189-t7mbsr25 665 18 immunofl immunofl NNP cord-024189-t7mbsr25 665 19 uorescence uorescence NNP cord-024189-t7mbsr25 665 20 was be VBD cord-024189-t7mbsr25 665 21 only only RB cord-024189-t7mbsr25 665 22 57 57 CD cord-024189-t7mbsr25 665 23 % % NN cord-024189-t7mbsr25 665 24 in in IN cord-024189-t7mbsr25 665 25 a a DT cord-024189-t7mbsr25 665 26 prospective prospective JJ cord-024189-t7mbsr25 665 27 study study NN cord-024189-t7mbsr25 665 28 , , , cord-024189-t7mbsr25 665 29 compared compare VBN cord-024189-t7mbsr25 665 30 with with IN cord-024189-t7mbsr25 665 31 71 71 CD cord-024189-t7mbsr25 665 32 % % NN cord-024189-t7mbsr25 665 33 for for IN cord-024189-t7mbsr25 665 34 enzyme enzyme NN cord-024189-t7mbsr25 665 35 immunoassay immunoassay NN cord-024189-t7mbsr25 665 36 ( ( -LRB- cord-024189-t7mbsr25 665 37 14 14 CD cord-024189-t7mbsr25 665 38 ) ) -RRB- cord-024189-t7mbsr25 665 39 . . . cord-024189-t7mbsr25 666 1 Moreover moreover RB cord-024189-t7mbsr25 666 2 , , , cord-024189-t7mbsr25 666 3 among among IN cord-024189-t7mbsr25 666 4 patients patient NNS cord-024189-t7mbsr25 666 5 with with IN cord-024189-t7mbsr25 666 6 an an DT cord-024189-t7mbsr25 666 7 elevation elevation NN cord-024189-t7mbsr25 666 8 of of IN cord-024189-t7mbsr25 666 9 ANCA ANCA NNP cord-024189-t7mbsr25 666 10 titers titer NNS cord-024189-t7mbsr25 666 11 measured measure VBN cord-024189-t7mbsr25 666 12 by by IN cord-024189-t7mbsr25 666 13 enzyme enzyme NN cord-024189-t7mbsr25 666 14 immunoassay immunoassay NN cord-024189-t7mbsr25 666 15 , , , cord-024189-t7mbsr25 666 16 only only RB cord-024189-t7mbsr25 666 17 39 39 CD cord-024189-t7mbsr25 666 18 % % NN cord-024189-t7mbsr25 666 19 suffered suffer VBD cord-024189-t7mbsr25 666 20 disease disease NN cord-024189-t7mbsr25 666 21 fl fl NNP cord-024189-t7mbsr25 666 22 ares ares NNP cord-024189-t7mbsr25 666 23 within within IN cord-024189-t7mbsr25 666 24 6 6 CD cord-024189-t7mbsr25 666 25 months month NNS cord-024189-t7mbsr25 666 26 . . . cord-024189-t7mbsr25 667 1 A a DT cord-024189-t7mbsr25 667 2 more more RBR cord-024189-t7mbsr25 667 3 recent recent JJ cord-024189-t7mbsr25 667 4 prospective prospective JJ cord-024189-t7mbsr25 667 5 study study NN cord-024189-t7mbsr25 667 6 ( ( -LRB- cord-024189-t7mbsr25 667 7 15 15 CD cord-024189-t7mbsr25 667 8 ) ) -RRB- cord-024189-t7mbsr25 667 9 showed show VBD cord-024189-t7mbsr25 667 10 that that IN cord-024189-t7mbsr25 667 11 increases increase NNS cord-024189-t7mbsr25 667 12 in in IN cord-024189-t7mbsr25 667 13 PR3-ANCA PR3-ANCA NNP cord-024189-t7mbsr25 667 14 levels level NNS cord-024189-t7mbsr25 667 15 did do VBD cord-024189-t7mbsr25 667 16 not not RB cord-024189-t7mbsr25 667 17 predict predict VB cord-024189-t7mbsr25 667 18 disease disease NN cord-024189-t7mbsr25 667 19 relapses relapse NNS cord-024189-t7mbsr25 667 20 . . . cord-024189-t7mbsr25 668 1 The the DT cord-024189-t7mbsr25 668 2 proportion proportion NN cord-024189-t7mbsr25 668 3 of of IN cord-024189-t7mbsr25 668 4 patients patient NNS cord-024189-t7mbsr25 668 5 who who WP cord-024189-t7mbsr25 668 6 relapsed relapse VBD cord-024189-t7mbsr25 668 7 within within IN cord-024189-t7mbsr25 668 8 1 1 CD cord-024189-t7mbsr25 668 9 year year NN cord-024189-t7mbsr25 668 10 following follow VBG cord-024189-t7mbsr25 668 11 an an DT cord-024189-t7mbsr25 668 12 increase increase NN cord-024189-t7mbsr25 668 13 in in IN cord-024189-t7mbsr25 668 14 ANCA ANCA NNP cord-024189-t7mbsr25 668 15 levels level NNS cord-024189-t7mbsr25 668 16 was be VBD cord-024189-t7mbsr25 668 17 only only RB cord-024189-t7mbsr25 668 18 40 40 CD cord-024189-t7mbsr25 668 19 % % NN cord-024189-t7mbsr25 668 20 . . . cord-024189-t7mbsr25 669 1 Although although IN cord-024189-t7mbsr25 669 2 some some DT cord-024189-t7mbsr25 669 3 studies study NNS cord-024189-t7mbsr25 669 4 suggest suggest VBP cord-024189-t7mbsr25 669 5 that that IN cord-024189-t7mbsr25 669 6 a a DT cord-024189-t7mbsr25 669 7 rise rise NN cord-024189-t7mbsr25 669 8 in in IN cord-024189-t7mbsr25 669 9 ANCA ANCA NNP cord-024189-t7mbsr25 669 10 titer titer NN cord-024189-t7mbsr25 669 11 is be VBZ cord-024189-t7mbsr25 669 12 a a DT cord-024189-t7mbsr25 669 13 risk risk NN cord-024189-t7mbsr25 669 14 factor factor NN cord-024189-t7mbsr25 669 15 for for IN cord-024189-t7mbsr25 669 16 a a DT cord-024189-t7mbsr25 669 17 fl fl NNP cord-024189-t7mbsr25 669 18 are be VBP cord-024189-t7mbsr25 669 19 , , , cord-024189-t7mbsr25 669 20 the the DT cord-024189-t7mbsr25 669 21 temporal temporal JJ cord-024189-t7mbsr25 669 22 relationship relationship NN cord-024189-t7mbsr25 669 23 between between IN cord-024189-t7mbsr25 669 24 a a DT cord-024189-t7mbsr25 669 25 rise rise NN cord-024189-t7mbsr25 669 26 in in IN cord-024189-t7mbsr25 669 27 ANCA ANCA NNP cord-024189-t7mbsr25 669 28 titers titer NNS cord-024189-t7mbsr25 669 29 and and CC cord-024189-t7mbsr25 669 30 the the DT cord-024189-t7mbsr25 669 31 development development NN cord-024189-t7mbsr25 669 32 of of IN cord-024189-t7mbsr25 669 33 disease disease NN cord-024189-t7mbsr25 669 34 activity activity NN cord-024189-t7mbsr25 669 35 requiring require VBG cord-024189-t7mbsr25 669 36 treatment treatment NN cord-024189-t7mbsr25 669 37 is be VBZ cord-024189-t7mbsr25 669 38 very very RB cord-024189-t7mbsr25 669 39 poor poor JJ cord-024189-t7mbsr25 669 40 , , , cord-024189-t7mbsr25 669 41 with with IN cord-024189-t7mbsr25 669 42 months month NNS cord-024189-t7mbsr25 669 43 to to IN cord-024189-t7mbsr25 669 44 years year NNS cord-024189-t7mbsr25 669 45 between between IN cord-024189-t7mbsr25 669 46 these these DT cord-024189-t7mbsr25 669 47 two two CD cord-024189-t7mbsr25 669 48 events event NNS cord-024189-t7mbsr25 669 49 . . . cord-024189-t7mbsr25 670 1 Thus thus RB cord-024189-t7mbsr25 670 2 , , , cord-024189-t7mbsr25 670 3 the the DT cord-024189-t7mbsr25 670 4 adjustment adjustment NN cord-024189-t7mbsr25 670 5 of of IN cord-024189-t7mbsr25 670 6 immunosuppressive immunosuppressive JJ cord-024189-t7mbsr25 670 7 medications medication NNS cord-024189-t7mbsr25 670 8 based base VBN cord-024189-t7mbsr25 670 9 solely solely RB cord-024189-t7mbsr25 670 10 on on IN cord-024189-t7mbsr25 670 11 the the DT cord-024189-t7mbsr25 670 12 rise rise NN cord-024189-t7mbsr25 670 13 or or CC cord-024189-t7mbsr25 670 14 fall fall NN cord-024189-t7mbsr25 670 15 of of IN cord-024189-t7mbsr25 670 16 ANCA ANCA NNP cord-024189-t7mbsr25 670 17 titers titer NNS cord-024189-t7mbsr25 670 18 is be VBZ cord-024189-t7mbsr25 670 19 never never RB cord-024189-t7mbsr25 670 20 justifi justifi NNP cord-024189-t7mbsr25 670 21 ed ed NN cord-024189-t7mbsr25 670 22 . . . cord-024189-t7mbsr25 671 1 The the DT cord-024189-t7mbsr25 671 2 AAVs aav NNS cord-024189-t7mbsr25 671 3 are be VBP cord-024189-t7mbsr25 671 4 complex complex JJ cord-024189-t7mbsr25 671 5 disorders disorder NNS cord-024189-t7mbsr25 671 6 mediated mediate VBN cord-024189-t7mbsr25 671 7 by by IN cord-024189-t7mbsr25 671 8 the the DT cord-024189-t7mbsr25 671 9 immune immune JJ cord-024189-t7mbsr25 671 10 system system NN cord-024189-t7mbsr25 671 11 in in IN cord-024189-t7mbsr25 671 12 which which WDT cord-024189-t7mbsr25 671 13 tissue tissue NN cord-024189-t7mbsr25 671 14 injury injury NN cord-024189-t7mbsr25 671 15 results result NNS cord-024189-t7mbsr25 671 16 from from IN cord-024189-t7mbsr25 671 17 the the DT cord-024189-t7mbsr25 671 18 interplay interplay NN cord-024189-t7mbsr25 671 19 between between IN cord-024189-t7mbsr25 671 20 an an DT cord-024189-t7mbsr25 671 21 initiating initiate VBG cord-024189-t7mbsr25 671 22 infl infl NNP cord-024189-t7mbsr25 671 23 ammatory ammatory NNP cord-024189-t7mbsr25 671 24 event event NN cord-024189-t7mbsr25 671 25 and and CC cord-024189-t7mbsr25 671 26 a a DT cord-024189-t7mbsr25 671 27 highly highly RB cord-024189-t7mbsr25 671 28 specifi specifi JJ cord-024189-t7mbsr25 671 29 c c NN cord-024189-t7mbsr25 671 30 pathogenic pathogenic JJ cord-024189-t7mbsr25 671 31 immune immune JJ cord-024189-t7mbsr25 671 32 response response NN cord-024189-t7mbsr25 671 33 ( ( -LRB- cord-024189-t7mbsr25 671 34 i.e. i.e. FW cord-024189-t7mbsr25 671 35 , , , cord-024189-t7mbsr25 671 36 the the DT cord-024189-t7mbsr25 671 37 production production NN cord-024189-t7mbsr25 671 38 of of IN cord-024189-t7mbsr25 671 39 ANCA ANCA NNP cord-024189-t7mbsr25 671 40 ) ) -RRB- cord-024189-t7mbsr25 671 41 to to TO cord-024189-t7mbsr25 671 42 previously previously RB cord-024189-t7mbsr25 671 43 shielded shield VBN cord-024189-t7mbsr25 671 44 epitopes epitope NNS cord-024189-t7mbsr25 671 45 of of IN cord-024189-t7mbsr25 671 46 neutrophil neutrophil NN cord-024189-t7mbsr25 671 47 granule granule NN cord-024189-t7mbsr25 671 48 proteins protein NNS cord-024189-t7mbsr25 671 49 . . . cord-024189-t7mbsr25 672 1 ANCAs anca NNS cord-024189-t7mbsr25 672 2 produce produce VBP cord-024189-t7mbsr25 672 3 tissue tissue NN cord-024189-t7mbsr25 672 4 damage damage NN cord-024189-t7mbsr25 672 5 via via IN cord-024189-t7mbsr25 672 6 interactions interaction NNS cord-024189-t7mbsr25 672 7 with with IN cord-024189-t7mbsr25 672 8 primed primed JJ cord-024189-t7mbsr25 672 9 neutrophils neutrophil NNS cord-024189-t7mbsr25 672 10 and and CC cord-024189-t7mbsr25 672 11 endothelial endothelial JJ cord-024189-t7mbsr25 672 12 cells cell NNS cord-024189-t7mbsr25 672 13 . . . cord-024189-t7mbsr25 673 1 The the DT cord-024189-t7mbsr25 673 2 hypothesis hypothesis NN cord-024189-t7mbsr25 673 3 , , , cord-024189-t7mbsr25 673 4 supported support VBN cord-024189-t7mbsr25 673 5 strongly strongly RB cord-024189-t7mbsr25 673 6 by by IN cord-024189-t7mbsr25 673 7 in in FW cord-024189-t7mbsr25 673 8 vitro vitro FW cord-024189-t7mbsr25 673 9 evidence evidence NN cord-024189-t7mbsr25 673 10 , , , cord-024189-t7mbsr25 673 11 is be VBZ cord-024189-t7mbsr25 673 12 that that IN cord-024189-t7mbsr25 673 13 the the DT cord-024189-t7mbsr25 673 14 antibodies antibody NNS cord-024189-t7mbsr25 673 15 induce induce VBP cord-024189-t7mbsr25 673 16 a a DT cord-024189-t7mbsr25 673 17 necrotizing necrotize VBG cord-024189-t7mbsr25 673 18 vasculitis vasculitis NN cord-024189-t7mbsr25 673 19 by by IN cord-024189-t7mbsr25 673 20 inciting incite VBG cord-024189-t7mbsr25 673 21 a a DT cord-024189-t7mbsr25 673 22 respiratory respiratory JJ cord-024189-t7mbsr25 673 23 burst burst NN cord-024189-t7mbsr25 673 24 and and CC cord-024189-t7mbsr25 673 25 degranulation degranulation NN cord-024189-t7mbsr25 673 26 of of IN cord-024189-t7mbsr25 673 27 leukocytes leukocyte NNS cord-024189-t7mbsr25 673 28 ( ( -LRB- cord-024189-t7mbsr25 673 29 neutrophils neutrophil NNS cord-024189-t7mbsr25 673 30 and and CC cord-024189-t7mbsr25 673 31 monocytes monocyte NNS cord-024189-t7mbsr25 673 32 ) ) -RRB- cord-024189-t7mbsr25 673 33 , , , cord-024189-t7mbsr25 673 34 leading lead VBG cord-024189-t7mbsr25 673 35 to to IN cord-024189-t7mbsr25 673 36 endothelial endothelial JJ cord-024189-t7mbsr25 673 37 injury injury NN cord-024189-t7mbsr25 673 38 . . . cord-024189-t7mbsr25 674 1 The the DT cord-024189-t7mbsr25 674 2 initial initial JJ cord-024189-t7mbsr25 674 3 events event NNS cord-024189-t7mbsr25 674 4 in in IN cord-024189-t7mbsr25 674 5 the the DT cord-024189-t7mbsr25 674 6 process process NN cord-024189-t7mbsr25 674 7 require require VBP cord-024189-t7mbsr25 674 8 the the DT cord-024189-t7mbsr25 674 9 priming priming NN cord-024189-t7mbsr25 674 10 of of IN cord-024189-t7mbsr25 674 11 leukocytes leukocyte NNS cord-024189-t7mbsr25 674 12 by by IN cord-024189-t7mbsr25 674 13 cytokines cytokine NNS cord-024189-t7mbsr25 674 14 and and CC cord-024189-t7mbsr25 674 15 perhaps perhaps RB cord-024189-t7mbsr25 674 16 other other JJ cord-024189-t7mbsr25 674 17 stimuli stimulus NNS cord-024189-t7mbsr25 674 18 , , , cord-024189-t7mbsr25 674 19 leading lead VBG cord-024189-t7mbsr25 674 20 to to IN cord-024189-t7mbsr25 674 21 the the DT cord-024189-t7mbsr25 674 22 expression expression NN cord-024189-t7mbsr25 674 23 of of IN cord-024189-t7mbsr25 674 24 PR3 PR3 NNP cord-024189-t7mbsr25 674 25 and and CC cord-024189-t7mbsr25 674 26 MPO MPO NNP cord-024189-t7mbsr25 674 27 on on IN cord-024189-t7mbsr25 674 28 the the DT cord-024189-t7mbsr25 674 29 cell cell NN cord-024189-t7mbsr25 674 30 surface surface NN cord-024189-t7mbsr25 674 31 . . . cord-024189-t7mbsr25 675 1 The the DT cord-024189-t7mbsr25 675 2 effects effect NNS cord-024189-t7mbsr25 675 3 of of IN cord-024189-t7mbsr25 675 4 ANCAs anca NNS cord-024189-t7mbsr25 675 5 are be VBP cord-024189-t7mbsr25 675 6 determined determine VBN cord-024189-t7mbsr25 675 7 by by IN cord-024189-t7mbsr25 675 8 the the DT cord-024189-t7mbsr25 675 9 state state NN cord-024189-t7mbsr25 675 10 of of IN cord-024189-t7mbsr25 675 11 neutrophil neutrophil NN cord-024189-t7mbsr25 675 12 activation activation NN cord-024189-t7mbsr25 675 13 . . . cord-024189-t7mbsr25 676 1 ANCAs anca NNS cord-024189-t7mbsr25 676 2 may may MD cord-024189-t7mbsr25 676 3 constitutively constitutively RB cord-024189-t7mbsr25 676 4 activate activate VB cord-024189-t7mbsr25 676 5 primed primed JJ cord-024189-t7mbsr25 676 6 neutrophils neutrophil NNS cord-024189-t7mbsr25 676 7 and and CC cord-024189-t7mbsr25 676 8 promote promote VB cord-024189-t7mbsr25 676 9 binding binding NN cord-024189-t7mbsr25 676 10 of of IN cord-024189-t7mbsr25 676 11 the the DT cord-024189-t7mbsr25 676 12 primed primed JJ cord-024189-t7mbsr25 676 13 neutrophils neutrophil NNS cord-024189-t7mbsr25 676 14 to to IN cord-024189-t7mbsr25 676 15 the the DT cord-024189-t7mbsr25 676 16 vascular vascular JJ cord-024189-t7mbsr25 676 17 endothelium endothelium NN cord-024189-t7mbsr25 676 18 , , , cord-024189-t7mbsr25 676 19 degranulation degranulation NN cord-024189-t7mbsr25 676 20 , , , cord-024189-t7mbsr25 676 21 and and CC cord-024189-t7mbsr25 676 22 the the DT cord-024189-t7mbsr25 676 23 release release NN cord-024189-t7mbsr25 676 24 of of IN cord-024189-t7mbsr25 676 25 neutrophil neutrophil NN cord-024189-t7mbsr25 676 26 chemoattractants chemoattractant NNS cord-024189-t7mbsr25 676 27 , , , cord-024189-t7mbsr25 676 28 hence hence RB cord-024189-t7mbsr25 676 29 creating create VBG cord-024189-t7mbsr25 676 30 an an DT cord-024189-t7mbsr25 676 31 autoamplifying autoamplifye VBG cord-024189-t7mbsr25 676 32 loop loop NN cord-024189-t7mbsr25 676 33 . . . cord-024189-t7mbsr25 677 1 There there EX cord-024189-t7mbsr25 677 2 is be VBZ cord-024189-t7mbsr25 677 3 now now RB cord-024189-t7mbsr25 677 4 substantial substantial JJ cord-024189-t7mbsr25 677 5 evidence evidence NN cord-024189-t7mbsr25 677 6 that that IN cord-024189-t7mbsr25 677 7 ANCAs anca NNS cord-024189-t7mbsr25 677 8 are be VBP cord-024189-t7mbsr25 677 9 directly directly RB cord-024189-t7mbsr25 677 10 involved involve VBN cord-024189-t7mbsr25 677 11 in in IN cord-024189-t7mbsr25 677 12 the the DT cord-024189-t7mbsr25 677 13 widespread widespread JJ cord-024189-t7mbsr25 677 14 tissue tissue NN cord-024189-t7mbsr25 677 15 damage damage NN cord-024189-t7mbsr25 677 16 that that WDT cord-024189-t7mbsr25 677 17 is be VBZ cord-024189-t7mbsr25 677 18 the the DT cord-024189-t7mbsr25 677 19 hallmark hallmark NN cord-024189-t7mbsr25 677 20 of of IN cord-024189-t7mbsr25 677 21 the the DT cord-024189-t7mbsr25 677 22 AAVs aav NNS cord-024189-t7mbsr25 677 23 . . . cord-024189-t7mbsr25 678 1 Recombinant recombinant JJ cord-024189-t7mbsr25 678 2 activating activate VBG cord-024189-t7mbsr25 678 3 gene gene NN cord-024189-t7mbsr25 678 4 2 2 CD cord-024189-t7mbsr25 679 1 ( ( -LRB- cord-024189-t7mbsr25 679 2 RAG-2)-defi rag-2)-defi JJ cord-024189-t7mbsr25 679 3 cient cient NN cord-024189-t7mbsr25 679 4 mice mouse NNS cord-024189-t7mbsr25 679 5 that that WDT cord-024189-t7mbsr25 679 6 receive receive VBP cord-024189-t7mbsr25 679 7 anti anti JJ cord-024189-t7mbsr25 679 8 - - JJ cord-024189-t7mbsr25 679 9 MPO MPO NNP cord-024189-t7mbsr25 679 10 antibodies antibody NNS cord-024189-t7mbsr25 679 11 develop develop VBP cord-024189-t7mbsr25 679 12 clinical clinical JJ cord-024189-t7mbsr25 679 13 features feature NNS cord-024189-t7mbsr25 679 14 consistent consistent JJ cord-024189-t7mbsr25 679 15 with with IN cord-024189-t7mbsr25 679 16 AAV AAV NNP cord-024189-t7mbsr25 679 17 , , , cord-024189-t7mbsr25 679 18 including include VBG cord-024189-t7mbsr25 679 19 crescentic crescentic JJ cord-024189-t7mbsr25 679 20 glomerulonephritis glomerulonephritis NN cord-024189-t7mbsr25 679 21 and and CC cord-024189-t7mbsr25 679 22 sys sys JJ cord-024189-t7mbsr25 679 23 - - HYPH cord-024189-t7mbsr25 679 24 temic temic JJ cord-024189-t7mbsr25 679 25 necrotizing necrotize VBG cord-024189-t7mbsr25 679 26 vasculitis vasculitis NN cord-024189-t7mbsr25 679 27 ( ( -LRB- cord-024189-t7mbsr25 679 28 16 16 CD cord-024189-t7mbsr25 679 29 ) ) -RRB- cord-024189-t7mbsr25 679 30 . . . cord-024189-t7mbsr25 680 1 In in IN cord-024189-t7mbsr25 680 2 humans human NNS cord-024189-t7mbsr25 680 3 , , , cord-024189-t7mbsr25 680 4 the the DT cord-024189-t7mbsr25 680 5 evidence evidence NN cord-024189-t7mbsr25 680 6 is be VBZ cord-024189-t7mbsr25 680 7 indirect indirect JJ cord-024189-t7mbsr25 680 8 . . . cord-024189-t7mbsr25 681 1 Propylthiouracil Propylthiouracil NNP cord-024189-t7mbsr25 681 2 is be VBZ cord-024189-t7mbsr25 681 3 known know VBN cord-024189-t7mbsr25 681 4 to to TO cord-024189-t7mbsr25 681 5 accumulate accumulate VB cord-024189-t7mbsr25 681 6 within within IN cord-024189-t7mbsr25 681 7 neutrophil neutrophil NN cord-024189-t7mbsr25 681 8 granules granule NNS cord-024189-t7mbsr25 681 9 and and CC cord-024189-t7mbsr25 681 10 may may MD cord-024189-t7mbsr25 681 11 lead lead VB cord-024189-t7mbsr25 681 12 to to IN cord-024189-t7mbsr25 681 13 a a DT cord-024189-t7mbsr25 681 14 druginduced druginduced JJ cord-024189-t7mbsr25 681 15 AAV AAV NNP cord-024189-t7mbsr25 681 16 ( ( -LRB- cord-024189-t7mbsr25 681 17 17 17 CD cord-024189-t7mbsr25 681 18 ) ) -RRB- cord-024189-t7mbsr25 681 19 , , , cord-024189-t7mbsr25 681 20 possibly possibly RB cord-024189-t7mbsr25 681 21 by by IN cord-024189-t7mbsr25 681 22 increasing increase VBG cord-024189-t7mbsr25 681 23 the the DT cord-024189-t7mbsr25 681 24 immunogenicity immunogenicity NN cord-024189-t7mbsr25 681 25 of of IN cord-024189-t7mbsr25 681 26 MPO MPO NNP cord-024189-t7mbsr25 681 27 ( ( -LRB- cord-024189-t7mbsr25 681 28 leading lead VBG cord-024189-t7mbsr25 681 29 to to IN cord-024189-t7mbsr25 681 30 the the DT cord-024189-t7mbsr25 681 31 characteristically characteristically RB cord-024189-t7mbsr25 681 32 high high JJ cord-024189-t7mbsr25 681 33 titers titer NNS cord-024189-t7mbsr25 681 34 of of IN cord-024189-t7mbsr25 681 35 MPO MPO NNP cord-024189-t7mbsr25 681 36 - - HYPH cord-024189-t7mbsr25 681 37 ANCA ANCA NNP cord-024189-t7mbsr25 681 38 seen see VBN cord-024189-t7mbsr25 681 39 in in IN cord-024189-t7mbsr25 681 40 this this DT cord-024189-t7mbsr25 681 41 disease disease NN cord-024189-t7mbsr25 681 42 ) ) -RRB- cord-024189-t7mbsr25 681 43 . . . cord-024189-t7mbsr25 682 1 In in IN cord-024189-t7mbsr25 682 2 addition addition NN cord-024189-t7mbsr25 682 3 to to IN cord-024189-t7mbsr25 682 4 ANCA ANCA NNP cord-024189-t7mbsr25 682 5 , , , cord-024189-t7mbsr25 682 6 multiple multiple JJ cord-024189-t7mbsr25 682 7 other other JJ cord-024189-t7mbsr25 682 8 elements element NNS cord-024189-t7mbsr25 682 9 of of IN cord-024189-t7mbsr25 682 10 the the DT cord-024189-t7mbsr25 682 11 immune immune JJ cord-024189-t7mbsr25 682 12 system system NN cord-024189-t7mbsr25 682 13 participate participate VBP cord-024189-t7mbsr25 682 14 in in IN cord-024189-t7mbsr25 682 15 the the DT cord-024189-t7mbsr25 682 16 pathophysiology pathophysiology NN cord-024189-t7mbsr25 682 17 of of IN cord-024189-t7mbsr25 682 18 these these DT cord-024189-t7mbsr25 682 19 diseases disease NNS cord-024189-t7mbsr25 682 20 . . . cord-024189-t7mbsr25 683 1 If if IN cord-024189-t7mbsr25 683 2 the the DT cord-024189-t7mbsr25 683 3 autoantibody autoantibody NNP cord-024189-t7mbsr25 683 4 response response NN cord-024189-t7mbsr25 683 5 leading lead VBG cord-024189-t7mbsr25 683 6 to to IN cord-024189-t7mbsr25 683 7 ANCA ANCA NNP cord-024189-t7mbsr25 683 8 production production NN cord-024189-t7mbsr25 683 9 follows follow VBZ cord-024189-t7mbsr25 683 10 the the DT cord-024189-t7mbsr25 683 11 exposure exposure NN cord-024189-t7mbsr25 683 12 of of IN cord-024189-t7mbsr25 683 13 a a DT cord-024189-t7mbsr25 683 14 cryptic cryptic JJ cord-024189-t7mbsr25 683 15 epitope epitope NN cord-024189-t7mbsr25 683 16 , , , cord-024189-t7mbsr25 683 17 epitope epitope NN cord-024189-t7mbsr25 683 18 spreading spread VBG cord-024189-t7mbsr25 683 19 may may MD cord-024189-t7mbsr25 683 20 then then RB cord-024189-t7mbsr25 683 21 generalize generalize VB cord-024189-t7mbsr25 683 22 the the DT cord-024189-t7mbsr25 683 23 antibody antibody NN cord-024189-t7mbsr25 683 24 response response NN cord-024189-t7mbsr25 683 25 to to IN cord-024189-t7mbsr25 683 26 the the DT cord-024189-t7mbsr25 683 27 rest rest NN cord-024189-t7mbsr25 683 28 of of IN cord-024189-t7mbsr25 683 29 the the DT cord-024189-t7mbsr25 683 30 molecule molecule NN cord-024189-t7mbsr25 683 31 . . . cord-024189-t7mbsr25 684 1 This this DT cord-024189-t7mbsr25 684 2 hypothesis hypothesis NN cord-024189-t7mbsr25 684 3 implies imply VBZ cord-024189-t7mbsr25 684 4 a a DT cord-024189-t7mbsr25 684 5 prominent prominent JJ cord-024189-t7mbsr25 684 6 role role NN cord-024189-t7mbsr25 684 7 for for IN cord-024189-t7mbsr25 684 8 the the DT cord-024189-t7mbsr25 684 9 T T NNP cord-024189-t7mbsr25 684 10 cell cell NN cord-024189-t7mbsr25 684 11 in in IN cord-024189-t7mbsr25 684 12 the the DT cord-024189-t7mbsr25 684 13 pathogenesis pathogenesis NN cord-024189-t7mbsr25 684 14 of of IN cord-024189-t7mbsr25 684 15 the the DT cord-024189-t7mbsr25 684 16 AAVs aav NNS cord-024189-t7mbsr25 684 17 . . . cord-024189-t7mbsr25 685 1 Moreover moreover RB cord-024189-t7mbsr25 685 2 , , , cord-024189-t7mbsr25 685 3 most most JJS cord-024189-t7mbsr25 685 4 patients patient NNS cord-024189-t7mbsr25 685 5 with with IN cord-024189-t7mbsr25 685 6 AAVs aav NNS cord-024189-t7mbsr25 685 7 produce produce VBP cord-024189-t7mbsr25 685 8 isotype isotype NN cord-024189-t7mbsr25 685 9 - - HYPH cord-024189-t7mbsr25 685 10 switched switch VBN cord-024189-t7mbsr25 685 11 IgG igg NN cord-024189-t7mbsr25 685 12 ANCA ANCA NNP cord-024189-t7mbsr25 685 13 , , , cord-024189-t7mbsr25 685 14 implying imply VBG cord-024189-t7mbsr25 685 15 a a DT cord-024189-t7mbsr25 685 16 secondary secondary JJ cord-024189-t7mbsr25 685 17 immune immune JJ cord-024189-t7mbsr25 685 18 response response NN cord-024189-t7mbsr25 685 19 driven drive VBN cord-024189-t7mbsr25 685 20 by by IN cord-024189-t7mbsr25 685 21 T T NNP cord-024189-t7mbsr25 685 22 cells cell NNS cord-024189-t7mbsr25 685 23 . . . cord-024189-t7mbsr25 686 1 Growing grow VBG cord-024189-t7mbsr25 686 2 evidence evidence NN cord-024189-t7mbsr25 686 3 , , , cord-024189-t7mbsr25 686 4 particularly particularly RB cord-024189-t7mbsr25 686 5 data datum NNS cord-024189-t7mbsr25 686 6 from from IN cord-024189-t7mbsr25 686 7 clinical clinical JJ cord-024189-t7mbsr25 686 8 studies study NNS cord-024189-t7mbsr25 686 9 ( ( -LRB- cord-024189-t7mbsr25 686 10 18 18 CD cord-024189-t7mbsr25 686 11 ) ) -RRB- cord-024189-t7mbsr25 686 12 , , , cord-024189-t7mbsr25 686 13 now now RB cord-024189-t7mbsr25 686 14 also also RB cord-024189-t7mbsr25 686 15 implicates implicate VBZ cord-024189-t7mbsr25 686 16 B b NN cord-024189-t7mbsr25 686 17 cells cell NNS cord-024189-t7mbsr25 686 18 as as IN cord-024189-t7mbsr25 686 19 important important JJ cord-024189-t7mbsr25 686 20 participants participant NNS cord-024189-t7mbsr25 686 21 in in IN cord-024189-t7mbsr25 686 22 the the DT cord-024189-t7mbsr25 686 23 infl infl NN cord-024189-t7mbsr25 686 24 ammation ammation NN cord-024189-t7mbsr25 686 25 of of IN cord-024189-t7mbsr25 686 26 AAV AAV NNP cord-024189-t7mbsr25 686 27 . . . cord-024189-t7mbsr25 687 1 As as IN cord-024189-t7mbsr25 687 2 the the DT cord-024189-t7mbsr25 687 3 precursors precursor NNS cord-024189-t7mbsr25 687 4 of of IN cord-024189-t7mbsr25 687 5 plasma plasma NN cord-024189-t7mbsr25 687 6 cells cell NNS cord-024189-t7mbsr25 687 7 ( ( -LRB- cord-024189-t7mbsr25 687 8 which which WDT cord-024189-t7mbsr25 687 9 produce produce VBP cord-024189-t7mbsr25 687 10 ANCA ANCA NNP cord-024189-t7mbsr25 687 11 ) ) -RRB- cord-024189-t7mbsr25 687 12 , , , cord-024189-t7mbsr25 687 13 B b NN cord-024189-t7mbsr25 687 14 cells cell NNS cord-024189-t7mbsr25 687 15 now now RB cord-024189-t7mbsr25 687 16 seem seem VBP cord-024189-t7mbsr25 687 17 a a DT cord-024189-t7mbsr25 687 18 logical logical JJ cord-024189-t7mbsr25 687 19 therapeutic therapeutic JJ cord-024189-t7mbsr25 687 20 target target NN cord-024189-t7mbsr25 687 21 in in IN cord-024189-t7mbsr25 687 22 AAV AAV NNP cord-024189-t7mbsr25 687 23 . . . cord-024189-t7mbsr25 688 1 In in IN cord-024189-t7mbsr25 688 2 addition addition NN cord-024189-t7mbsr25 688 3 to to IN cord-024189-t7mbsr25 688 4 disrupting disrupt VBG cord-024189-t7mbsr25 688 5 ANCA ANCA NNP cord-024189-t7mbsr25 688 6 production production NN cord-024189-t7mbsr25 688 7 , , , cord-024189-t7mbsr25 688 8 however however RB cord-024189-t7mbsr25 688 9 , , , cord-024189-t7mbsr25 688 10 interference interference NN cord-024189-t7mbsr25 688 11 with with IN cord-024189-t7mbsr25 688 12 B b NN cord-024189-t7mbsr25 688 13 - - HYPH cord-024189-t7mbsr25 688 14 cell cell NN cord-024189-t7mbsr25 688 15 function function NN cord-024189-t7mbsr25 688 16 may may MD cord-024189-t7mbsr25 688 17 also also RB cord-024189-t7mbsr25 688 18 ameliorate ameliorate VB cord-024189-t7mbsr25 688 19 AAV AAV NNP cord-024189-t7mbsr25 688 20 by by IN cord-024189-t7mbsr25 688 21 disabling disable VBG cord-024189-t7mbsr25 688 22 critical critical JJ cord-024189-t7mbsr25 688 23 B b NN cord-024189-t7mbsr25 688 24 cell cell NN cord-024189-t7mbsr25 688 25 / / SYM cord-024189-t7mbsr25 688 26 T t NN cord-024189-t7mbsr25 688 27 cell cell NN cord-024189-t7mbsr25 688 28 interactions interaction NNS cord-024189-t7mbsr25 688 29 , , , cord-024189-t7mbsr25 688 30 by by IN cord-024189-t7mbsr25 688 31 removing remove VBG cord-024189-t7mbsr25 688 32 the the DT cord-024189-t7mbsr25 688 33 antigen antigen NN cord-024189-t7mbsr25 688 34 presenting present VBG cord-024189-t7mbsr25 688 35 function function NN cord-024189-t7mbsr25 688 36 of of IN cord-024189-t7mbsr25 688 37 B b NN cord-024189-t7mbsr25 688 38 cells cell NNS cord-024189-t7mbsr25 688 39 , , , cord-024189-t7mbsr25 688 40 and and CC cord-024189-t7mbsr25 688 41 perhaps perhaps RB cord-024189-t7mbsr25 688 42 other other JJ cord-024189-t7mbsr25 688 43 mechanisms mechanism NNS cord-024189-t7mbsr25 688 44 . . . cord-024189-t7mbsr25 689 1 B b NN cord-024189-t7mbsr25 689 2 - - HYPH cord-024189-t7mbsr25 689 3 cell cell NN cord-024189-t7mbsr25 689 4 depletion depletion NN cord-024189-t7mbsr25 689 5 is be VBZ cord-024189-t7mbsr25 689 6 the the DT cord-024189-t7mbsr25 689 7 focus focus NN cord-024189-t7mbsr25 689 8 of of IN cord-024189-t7mbsr25 689 9 ongoing ongoing JJ cord-024189-t7mbsr25 689 10 randomized randomized JJ cord-024189-t7mbsr25 689 11 trials trial NNS cord-024189-t7mbsr25 689 12 involving involve VBG cord-024189-t7mbsr25 689 13 patients patient NNS cord-024189-t7mbsr25 689 14 with with IN cord-024189-t7mbsr25 689 15 WG WG NNP cord-024189-t7mbsr25 689 16 and and CC cord-024189-t7mbsr25 689 17 MPA MPA NNP cord-024189-t7mbsr25 689 18 . . . cord-024189-t7mbsr25 690 1 The the DT cord-024189-t7mbsr25 690 2 pathophysiology pathophysiology NN cord-024189-t7mbsr25 690 3 of of IN cord-024189-t7mbsr25 690 4 CSS css NN cord-024189-t7mbsr25 690 5 likely likely RB cord-024189-t7mbsr25 690 6 bears bear VBZ cord-024189-t7mbsr25 690 7 many many JJ cord-024189-t7mbsr25 690 8 similarities similarity NNS cord-024189-t7mbsr25 690 9 to to IN cord-024189-t7mbsr25 690 10 that that DT cord-024189-t7mbsr25 690 11 of of IN cord-024189-t7mbsr25 690 12 WG WG NNP cord-024189-t7mbsr25 690 13 and and CC cord-024189-t7mbsr25 690 14 MPA MPA NNP cord-024189-t7mbsr25 690 15 , , , cord-024189-t7mbsr25 690 16 albeit albeit IN cord-024189-t7mbsr25 690 17 ANCA ANCA NNP cord-024189-t7mbsr25 690 18 are be VBP cord-024189-t7mbsr25 690 19 less less RBR cord-024189-t7mbsr25 690 20 common common JJ cord-024189-t7mbsr25 690 21 in in IN cord-024189-t7mbsr25 690 22 CSS css NN cord-024189-t7mbsr25 690 23 . . . cord-024189-t7mbsr25 691 1 In in IN cord-024189-t7mbsr25 691 2 the the DT cord-024189-t7mbsr25 691 3 CSS css NN cord-024189-t7mbsr25 691 4 , , , cord-024189-t7mbsr25 691 5 however however RB cord-024189-t7mbsr25 691 6 , , , cord-024189-t7mbsr25 691 7 relatively relatively RB cord-024189-t7mbsr25 691 8 little little JJ cord-024189-t7mbsr25 691 9 is be VBZ cord-024189-t7mbsr25 691 10 currently currently RB cord-024189-t7mbsr25 691 11 understood understand VBN cord-024189-t7mbsr25 691 12 about about IN cord-024189-t7mbsr25 691 13 the the DT cord-024189-t7mbsr25 691 14 special special JJ cord-024189-t7mbsr25 691 15 role role NN cord-024189-t7mbsr25 691 16 played play VBN cord-024189-t7mbsr25 691 17 by by IN cord-024189-t7mbsr25 691 18 the the DT cord-024189-t7mbsr25 691 19 eosinophil eosinophil NN cord-024189-t7mbsr25 691 20 in in IN cord-024189-t7mbsr25 691 21 that that DT cord-024189-t7mbsr25 691 22 disease disease NN cord-024189-t7mbsr25 691 23 . . . cord-024189-t7mbsr25 692 1 Because because IN cord-024189-t7mbsr25 692 2 of of IN cord-024189-t7mbsr25 692 3 their -PRON- PRP$ cord-024189-t7mbsr25 692 4 multiorgan multiorgan NN cord-024189-t7mbsr25 692 5 system system NN cord-024189-t7mbsr25 692 6 nature nature NN cord-024189-t7mbsr25 692 7 , , , cord-024189-t7mbsr25 692 8 the the DT cord-024189-t7mbsr25 692 9 differential differential JJ cord-024189-t7mbsr25 692 10 diagnosis diagnosis NN cord-024189-t7mbsr25 692 11 of of IN cord-024189-t7mbsr25 692 12 AAV AAV NNP cord-024189-t7mbsr25 692 13 is be VBZ cord-024189-t7mbsr25 692 14 lengthy lengthy JJ cord-024189-t7mbsr25 692 15 . . . cord-024189-t7mbsr25 693 1 One one CD cord-024189-t7mbsr25 693 2 frequently frequently RB cord-024189-t7mbsr25 693 3 challenging challenge VBG cord-024189-t7mbsr25 693 4 task task NN cord-024189-t7mbsr25 693 5 is be VBZ cord-024189-t7mbsr25 693 6 the the DT cord-024189-t7mbsr25 693 7 differentiation differentiation NN cord-024189-t7mbsr25 693 8 of of IN cord-024189-t7mbsr25 693 9 these these DT cord-024189-t7mbsr25 693 10 diseases disease NNS cord-024189-t7mbsr25 693 11 from from IN cord-024189-t7mbsr25 693 12 other other JJ cord-024189-t7mbsr25 693 13 forms form NNS cord-024189-t7mbsr25 693 14 of of IN cord-024189-t7mbsr25 693 15 vasculitis vasculitis NN cord-024189-t7mbsr25 693 16 . . . cord-024189-t7mbsr25 694 1 Indeed indeed RB cord-024189-t7mbsr25 694 2 , , , cord-024189-t7mbsr25 694 3 clear clear JJ cord-024189-t7mbsr25 694 4 distinctions distinction NNS cord-024189-t7mbsr25 694 5 are be VBP cord-024189-t7mbsr25 694 6 often often RB cord-024189-t7mbsr25 694 7 impossible impossible JJ cord-024189-t7mbsr25 694 8 between between IN cord-024189-t7mbsr25 694 9 WG WG NNP cord-024189-t7mbsr25 694 10 and and CC cord-024189-t7mbsr25 694 11 MPA MPA NNP cord-024189-t7mbsr25 694 12 , , , cord-024189-t7mbsr25 694 13 because because IN cord-024189-t7mbsr25 694 14 granulomatous granulomatous JJ cord-024189-t7mbsr25 694 15 infl infl NN cord-024189-t7mbsr25 694 16 ammation ammation NN cord-024189-t7mbsr25 694 17 is be VBZ cord-024189-t7mbsr25 694 18 not not RB cord-024189-t7mbsr25 694 19 detected detect VBN cord-024189-t7mbsr25 694 20 on on IN cord-024189-t7mbsr25 694 21 all all DT cord-024189-t7mbsr25 694 22 biopsy biopsy NN cord-024189-t7mbsr25 694 23 specimens specimen NNS cord-024189-t7mbsr25 694 24 from from IN cord-024189-t7mbsr25 694 25 patients patient NNS cord-024189-t7mbsr25 694 26 with with IN cord-024189-t7mbsr25 694 27 WG WG NNP cord-024189-t7mbsr25 694 28 . . . cord-024189-t7mbsr25 695 1 Distinguishing distinguish VBG cord-024189-t7mbsr25 695 2 the the DT cord-024189-t7mbsr25 695 3 AAVs aav NNS cord-024189-t7mbsr25 695 4 from from IN cord-024189-t7mbsr25 695 5 other other JJ cord-024189-t7mbsr25 695 6 forms form NNS cord-024189-t7mbsr25 695 7 of of IN cord-024189-t7mbsr25 695 8 vasculitis vasculitis NN cord-024189-t7mbsr25 695 9 is be VBZ cord-024189-t7mbsr25 695 10 often often RB cord-024189-t7mbsr25 695 11 more more RBR cord-024189-t7mbsr25 695 12 critical critical JJ cord-024189-t7mbsr25 695 13 because because IN cord-024189-t7mbsr25 695 14 the the DT cord-024189-t7mbsr25 695 15 specifi specifi NN cord-024189-t7mbsr25 695 16 c c NN cord-024189-t7mbsr25 695 17 treatments treatment NNS cord-024189-t7mbsr25 695 18 differ differ VBP cord-024189-t7mbsr25 695 19 according accord VBG cord-024189-t7mbsr25 695 20 to to IN cord-024189-t7mbsr25 695 21 diagnosis diagnosis NN cord-024189-t7mbsr25 695 22 . . . cord-024189-t7mbsr25 696 1 In in IN cord-024189-t7mbsr25 696 2 addition addition NN cord-024189-t7mbsr25 696 3 , , , cord-024189-t7mbsr25 696 4 the the DT cord-024189-t7mbsr25 696 5 AAVs aav NNS cord-024189-t7mbsr25 696 6 must must MD cord-024189-t7mbsr25 696 7 be be VB cord-024189-t7mbsr25 696 8 distinguished distinguish VBN cord-024189-t7mbsr25 696 9 from from IN cord-024189-t7mbsr25 696 10 a a DT cord-024189-t7mbsr25 696 11 host host NN cord-024189-t7mbsr25 696 12 of of IN cord-024189-t7mbsr25 696 13 other other JJ cord-024189-t7mbsr25 696 14 disorders disorder NNS cord-024189-t7mbsr25 696 15 associated associate VBN cord-024189-t7mbsr25 696 16 with with IN cord-024189-t7mbsr25 696 17 infl infl NN cord-024189-t7mbsr25 696 18 ammation ammation NNP cord-024189-t7mbsr25 696 19 and and CC cord-024189-t7mbsr25 696 20 multiorgan multiorgan NNP cord-024189-t7mbsr25 696 21 system system NN cord-024189-t7mbsr25 696 22 dysfunction dysfunction NN cord-024189-t7mbsr25 696 23 . . . cord-024189-t7mbsr25 697 1 The the DT cord-024189-t7mbsr25 697 2 differential differential JJ cord-024189-t7mbsr25 697 3 diagnosis diagnosis NN cord-024189-t7mbsr25 697 4 of of IN cord-024189-t7mbsr25 697 5 AAV AAV NNP cord-024189-t7mbsr25 697 6 is be VBZ cord-024189-t7mbsr25 697 7 shown show VBN cord-024189-t7mbsr25 697 8 in in IN cord-024189-t7mbsr25 697 9 Table Table NNP cord-024189-t7mbsr25 697 10 21C-5 21c-5 CD cord-024189-t7mbsr25 697 11 . . . cord-024189-t7mbsr25 698 1 Churg Churg NNP cord-024189-t7mbsr25 698 2 - - HYPH cord-024189-t7mbsr25 698 3 Strauss Strauss NNP cord-024189-t7mbsr25 698 4 syndrome syndrome NN cord-024189-t7mbsr25 698 5 has have VBZ cord-024189-t7mbsr25 698 6 an an DT cord-024189-t7mbsr25 698 7 additional additional JJ cord-024189-t7mbsr25 698 8 major major JJ cord-024189-t7mbsr25 698 9 branch branch NN cord-024189-t7mbsr25 698 10 of of IN cord-024189-t7mbsr25 698 11 its -PRON- PRP$ cord-024189-t7mbsr25 698 12 differential differential JJ cord-024189-t7mbsr25 698 13 diagnosis diagnosis NN cord-024189-t7mbsr25 698 14 because because IN cord-024189-t7mbsr25 698 15 of of IN cord-024189-t7mbsr25 698 16 the the DT cord-024189-t7mbsr25 698 17 eosinophilia eosinophilia NN cord-024189-t7mbsr25 698 18 associated associate VBN cord-024189-t7mbsr25 698 19 with with IN cord-024189-t7mbsr25 698 20 the the DT cord-024189-t7mbsr25 698 21 disease disease NN cord-024189-t7mbsr25 698 22 . . . cord-024189-t7mbsr25 699 1 Allergic allergic JJ cord-024189-t7mbsr25 699 2 bronchopulmonary bronchopulmonary JJ cord-024189-t7mbsr25 699 3 aspergillosis aspergillosis NNP cord-024189-t7mbsr25 699 4 , , , cord-024189-t7mbsr25 699 5 chronic chronic JJ cord-024189-t7mbsr25 699 6 eosinophilic eosinophilic JJ cord-024189-t7mbsr25 699 7 pneumonia pneumonia NN cord-024189-t7mbsr25 699 8 , , , cord-024189-t7mbsr25 699 9 eosinophilic eosinophilic JJ cord-024189-t7mbsr25 699 10 gastroenteritis gastroenteritis NN cord-024189-t7mbsr25 699 11 , , , cord-024189-t7mbsr25 699 12 eosinophilic eosinophilic JJ cord-024189-t7mbsr25 699 13 fasciitis fasciitis NN cord-024189-t7mbsr25 699 14 , , , cord-024189-t7mbsr25 699 15 the the DT cord-024189-t7mbsr25 699 16 hypereosinophil hypereosinophil NNP cord-024189-t7mbsr25 699 17 syndrome syndrome NN cord-024189-t7mbsr25 699 18 , , , cord-024189-t7mbsr25 699 19 and and CC cord-024189-t7mbsr25 699 20 eosinophilic eosinophilic JJ cord-024189-t7mbsr25 699 21 leukemias leukemia NNS cord-024189-t7mbsr25 699 22 must must MD cord-024189-t7mbsr25 699 23 all all DT cord-024189-t7mbsr25 699 24 be be VB cord-024189-t7mbsr25 699 25 excluded exclude VBN cord-024189-t7mbsr25 699 26 . . . cord-024189-t7mbsr25 700 1 Current current JJ cord-024189-t7mbsr25 700 2 choices choice NNS cord-024189-t7mbsr25 700 3 for for IN cord-024189-t7mbsr25 700 4 treatment treatment NN cord-024189-t7mbsr25 700 5 in in IN cord-024189-t7mbsr25 700 6 WG WG NNP cord-024189-t7mbsr25 700 7 are be VBP cord-024189-t7mbsr25 700 8 based base VBN cord-024189-t7mbsr25 700 9 on on IN cord-024189-t7mbsr25 700 10 the the DT cord-024189-t7mbsr25 700 11 classifi classifi NNP cord-024189-t7mbsr25 700 12 cation cation NN cord-024189-t7mbsr25 700 13 of of IN cord-024189-t7mbsr25 700 14 patients patient NNS cord-024189-t7mbsr25 700 15 into into IN cord-024189-t7mbsr25 700 16 the the DT cord-024189-t7mbsr25 700 17 categories category NNS cord-024189-t7mbsr25 700 18 of of IN cord-024189-t7mbsr25 700 19 either either CC cord-024189-t7mbsr25 700 20 severe severe JJ cord-024189-t7mbsr25 700 21 or or CC cord-024189-t7mbsr25 700 22 limited limited JJ cord-024189-t7mbsr25 700 23 disease disease NN cord-024189-t7mbsr25 700 24 ( ( -LRB- cord-024189-t7mbsr25 700 25 19 19 CD cord-024189-t7mbsr25 700 26 ) ) -RRB- cord-024189-t7mbsr25 700 27 . . . cord-024189-t7mbsr25 701 1 Severe severe JJ cord-024189-t7mbsr25 701 2 WG WG NNP cord-024189-t7mbsr25 701 3 constitutes constitute VBZ cord-024189-t7mbsr25 701 4 an an DT cord-024189-t7mbsr25 701 5 immediate immediate JJ cord-024189-t7mbsr25 701 6 threat threat NN cord-024189-t7mbsr25 701 7 either either CC cord-024189-t7mbsr25 701 8 to to IN cord-024189-t7mbsr25 701 9 the the DT cord-024189-t7mbsr25 701 10 function function NN cord-024189-t7mbsr25 701 11 of of IN cord-024189-t7mbsr25 701 12 a a DT cord-024189-t7mbsr25 701 13 vital vital JJ cord-024189-t7mbsr25 701 14 organ organ NN cord-024189-t7mbsr25 701 15 or or CC cord-024189-t7mbsr25 701 16 to to IN cord-024189-t7mbsr25 701 17 the the DT cord-024189-t7mbsr25 701 18 patient patient NN cord-024189-t7mbsr25 701 19 's 's POS cord-024189-t7mbsr25 701 20 life life NN cord-024189-t7mbsr25 701 21 . . . cord-024189-t7mbsr25 702 1 Conversely conversely RB cord-024189-t7mbsr25 702 2 , , , cord-024189-t7mbsr25 702 3 limited limited JJ cord-024189-t7mbsr25 702 4 WG WG NNP cord-024189-t7mbsr25 702 5 consists consist VBZ cord-024189-t7mbsr25 702 6 of of IN cord-024189-t7mbsr25 702 7 disease disease NN cord-024189-t7mbsr25 702 8 manifestations manifestation NNS cord-024189-t7mbsr25 702 9 that that WDT cord-024189-t7mbsr25 702 10 do do VBP cord-024189-t7mbsr25 702 11 not not RB cord-024189-t7mbsr25 702 12 pose pose VB cord-024189-t7mbsr25 702 13 such such JJ cord-024189-t7mbsr25 702 14 threats threat NNS cord-024189-t7mbsr25 702 15 . . . cord-024189-t7mbsr25 703 1 The the DT cord-024189-t7mbsr25 703 2 practical practical JJ cord-024189-t7mbsr25 703 3 distinction distinction NN cord-024189-t7mbsr25 703 4 between between IN cord-024189-t7mbsr25 703 5 severe severe JJ cord-024189-t7mbsr25 703 6 and and CC cord-024189-t7mbsr25 703 7 limited limited JJ cord-024189-t7mbsr25 703 8 disease disease NN cord-024189-t7mbsr25 703 9 is be VBZ cord-024189-t7mbsr25 703 10 that that IN cord-024189-t7mbsr25 703 11 under under IN cord-024189-t7mbsr25 703 12 the the DT cord-024189-t7mbsr25 703 13 current current JJ cord-024189-t7mbsr25 703 14 standard standard NN cord-024189-t7mbsr25 703 15 of of IN cord-024189-t7mbsr25 703 16 care care NN cord-024189-t7mbsr25 703 17 the the DT cord-024189-t7mbsr25 703 18 diagnosis diagnosis NN cord-024189-t7mbsr25 703 19 of of IN cord-024189-t7mbsr25 703 20 severe severe JJ cord-024189-t7mbsr25 703 21 WG WG NNP cord-024189-t7mbsr25 703 22 mandates mandate VBZ cord-024189-t7mbsr25 703 23 the the DT cord-024189-t7mbsr25 703 24 use use NN cord-024189-t7mbsr25 703 25 of of IN cord-024189-t7mbsr25 703 26 cyclophosphamide cyclophosphamide NN cord-024189-t7mbsr25 703 27 , , , cord-024189-t7mbsr25 703 28 whereas whereas IN cord-024189-t7mbsr25 703 29 milder mild JJR cord-024189-t7mbsr25 703 30 therapeutic therapeutic JJ cord-024189-t7mbsr25 703 31 approaches approach NNS cord-024189-t7mbsr25 703 32 may may MD cord-024189-t7mbsr25 703 33 be be VB cord-024189-t7mbsr25 703 34 appropriate appropriate JJ cord-024189-t7mbsr25 703 35 and and CC cord-024189-t7mbsr25 703 36 should should MD cord-024189-t7mbsr25 703 37 be be VB cord-024189-t7mbsr25 703 38 considered consider VBN cord-024189-t7mbsr25 703 39 for for IN cord-024189-t7mbsr25 703 40 limited limited JJ cord-024189-t7mbsr25 703 41 disease disease NN cord-024189-t7mbsr25 703 42 . . . cord-024189-t7mbsr25 704 1 The the DT cord-024189-t7mbsr25 704 2 treatment treatment NN cord-024189-t7mbsr25 704 3 of of IN cord-024189-t7mbsr25 704 4 MPA MPA NNP cord-024189-t7mbsr25 704 5 parallels parallel VBZ cord-024189-t7mbsr25 704 6 very very RB cord-024189-t7mbsr25 704 7 closely closely RB cord-024189-t7mbsr25 704 8 that that DT cord-024189-t7mbsr25 704 9 of of IN cord-024189-t7mbsr25 704 10 severe severe JJ cord-024189-t7mbsr25 704 11 WG WG NNP cord-024189-t7mbsr25 704 12 . . . cord-024189-t7mbsr25 705 1 Because because IN cord-024189-t7mbsr25 705 2 of of IN cord-024189-t7mbsr25 705 3 the the DT cord-024189-t7mbsr25 705 4 propensity propensity NN cord-024189-t7mbsr25 705 5 of of IN cord-024189-t7mbsr25 705 6 MPA MPA NNP cord-024189-t7mbsr25 705 7 to to TO cord-024189-t7mbsr25 705 8 involve involve VB cord-024189-t7mbsr25 705 9 major major JJ cord-024189-t7mbsr25 705 10 organs organ NNS cord-024189-t7mbsr25 705 11 ( ( -LRB- cord-024189-t7mbsr25 705 12 lungs lung NNS cord-024189-t7mbsr25 705 13 , , , cord-024189-t7mbsr25 705 14 kidneys kidney NNS cord-024189-t7mbsr25 705 15 , , , cord-024189-t7mbsr25 705 16 peripheral peripheral JJ cord-024189-t7mbsr25 705 17 nerves nerve NNS cord-024189-t7mbsr25 705 18 ) ) -RRB- cord-024189-t7mbsr25 705 19 in in IN cord-024189-t7mbsr25 705 20 a a DT cord-024189-t7mbsr25 705 21 severe severe JJ cord-024189-t7mbsr25 705 22 fashion fashion NN cord-024189-t7mbsr25 705 23 , , , cord-024189-t7mbsr25 705 24 limited limited JJ cord-024189-t7mbsr25 705 25 forms form NNS cord-024189-t7mbsr25 705 26 of of IN cord-024189-t7mbsr25 705 27 the the DT cord-024189-t7mbsr25 705 28 disease disease NN cord-024189-t7mbsr25 705 29 are be VBP cord-024189-t7mbsr25 705 30 recognized recognize VBN cord-024189-t7mbsr25 705 31 less less RBR cord-024189-t7mbsr25 705 32 often often RB cord-024189-t7mbsr25 705 33 . . . cord-024189-t7mbsr25 706 1 Some some DT cord-024189-t7mbsr25 706 2 cases case NNS cord-024189-t7mbsr25 706 3 of of IN cord-024189-t7mbsr25 706 4 CSS css NN cord-024189-t7mbsr25 706 5 can can MD cord-024189-t7mbsr25 706 6 be be VB cord-024189-t7mbsr25 706 7 treated treat VBN cord-024189-t7mbsr25 706 8 with with IN cord-024189-t7mbsr25 706 9 glucocorticoids glucocorticoid NNS cord-024189-t7mbsr25 706 10 alone alone RB cord-024189-t7mbsr25 706 11 , , , cord-024189-t7mbsr25 706 12 but but CC cord-024189-t7mbsr25 706 13 those those DT cord-024189-t7mbsr25 706 14 with with IN cord-024189-t7mbsr25 706 15 vasculitic vasculitic JJ cord-024189-t7mbsr25 706 16 neuropathy neuropathy NN cord-024189-t7mbsr25 706 17 , , , cord-024189-t7mbsr25 706 18 life life NN cord-024189-t7mbsr25 706 19 - - HYPH cord-024189-t7mbsr25 706 20 threatening threaten VBG cord-024189-t7mbsr25 706 21 pulmonary pulmonary JJ cord-024189-t7mbsr25 706 22 involvement involvement NN cord-024189-t7mbsr25 706 23 , , , cord-024189-t7mbsr25 706 24 and and CC cord-024189-t7mbsr25 706 25 other other JJ cord-024189-t7mbsr25 706 26 sobering sobering JJ cord-024189-t7mbsr25 706 27 organ organ NN cord-024189-t7mbsr25 706 28 involvement involvement NN cord-024189-t7mbsr25 706 29 require require VBP cord-024189-t7mbsr25 706 30 cyclophosphamide cyclophosphamide RB cord-024189-t7mbsr25 706 31 from from IN cord-024189-t7mbsr25 706 32 the the DT cord-024189-t7mbsr25 706 33 outset outset NN cord-024189-t7mbsr25 706 34 of of IN cord-024189-t7mbsr25 706 35 therapy therapy NN cord-024189-t7mbsr25 706 36 . . . cord-024189-t7mbsr25 707 1 In in IN cord-024189-t7mbsr25 707 2 treating treat VBG cord-024189-t7mbsr25 707 3 severe severe JJ cord-024189-t7mbsr25 707 4 AAV AAV NNP cord-024189-t7mbsr25 707 5 , , , cord-024189-t7mbsr25 707 6 the the DT cord-024189-t7mbsr25 707 7 standard standard JJ cord-024189-t7mbsr25 707 8 approach approach NN cord-024189-t7mbsr25 707 9 now now RB cord-024189-t7mbsr25 707 10 is be VBZ cord-024189-t7mbsr25 707 11 to to TO cord-024189-t7mbsr25 707 12 employ employ VB cord-024189-t7mbsr25 707 13 cyclophosphamide cyclophosphamide JJ cord-024189-t7mbsr25 707 14 [ [ -LRB- cord-024189-t7mbsr25 707 15 e.g. e.g. RB cord-024189-t7mbsr25 707 16 , , , cord-024189-t7mbsr25 707 17 2 2 CD cord-024189-t7mbsr25 707 18 mg mg NNP cord-024189-t7mbsr25 707 19 / / SYM cord-024189-t7mbsr25 707 20 kg kg NNP cord-024189-t7mbsr25 707 21 / / SYM cord-024189-t7mbsr25 707 22 day day NN cord-024189-t7mbsr25 707 23 , , , cord-024189-t7mbsr25 707 24 adjusted adjust VBN cord-024189-t7mbsr25 707 25 for for IN cord-024189-t7mbsr25 707 26 renal renal JJ cord-024189-t7mbsr25 707 27 dysfunction dysfunction NN cord-024189-t7mbsr25 707 28 ( ( -LRB- cord-024189-t7mbsr25 707 29 20 20 CD cord-024189-t7mbsr25 707 30 ) ) -RRB- cord-024189-t7mbsr25 707 31 ] ] -RRB- cord-024189-t7mbsr25 707 32 for for IN cord-024189-t7mbsr25 707 33 3 3 CD cord-024189-t7mbsr25 707 34 to to TO cord-024189-t7mbsr25 707 35 6 6 CD cord-024189-t7mbsr25 707 36 months month NNS cord-024189-t7mbsr25 707 37 . . . cord-024189-t7mbsr25 708 1 Some some DT cord-024189-t7mbsr25 708 2 experts expert NNS cord-024189-t7mbsr25 708 3 prefer prefer VBP cord-024189-t7mbsr25 708 4 intermittent intermittent JJ cord-024189-t7mbsr25 708 5 ( ( -LRB- cord-024189-t7mbsr25 708 6 intravenous intravenous JJ cord-024189-t7mbsr25 708 7 ) ) -RRB- cord-024189-t7mbsr25 708 8 regimens regimen NNS cord-024189-t7mbsr25 708 9 of of IN cord-024189-t7mbsr25 708 10 cyclophosphamide cyclophosphamide NN cord-024189-t7mbsr25 708 11 ( ( -LRB- cord-024189-t7mbsr25 708 12 e.g. e.g. RB cord-024189-t7mbsr25 708 13 , , , cord-024189-t7mbsr25 708 14 500 500 CD cord-024189-t7mbsr25 708 15 - - SYM cord-024189-t7mbsr25 708 16 750 750 CD cord-024189-t7mbsr25 708 17 mg mg NNP cord-024189-t7mbsr25 708 18 / / SYM cord-024189-t7mbsr25 708 19 m m NN cord-024189-t7mbsr25 708 20 2 2 CD cord-024189-t7mbsr25 708 21 every every DT cord-024189-t7mbsr25 708 22 month month NN cord-024189-t7mbsr25 708 23 ) ) -RRB- cord-024189-t7mbsr25 708 24 . . . cord-024189-t7mbsr25 709 1 No no DT cord-024189-t7mbsr25 709 2 data data NN cord-024189-t7mbsr25 709 3 yet yet RB cord-024189-t7mbsr25 709 4 available available JJ cord-024189-t7mbsr25 709 5 strongly strongly RB cord-024189-t7mbsr25 709 6 endorse endorse VBP cord-024189-t7mbsr25 709 7 one one CD cord-024189-t7mbsr25 709 8 cyclophosphamide cyclophosphamide IN cord-024189-t7mbsr25 709 9 regimen regimen NN cord-024189-t7mbsr25 709 10 over over IN cord-024189-t7mbsr25 709 11 another another DT cord-024189-t7mbsr25 709 12 . . . cord-024189-t7mbsr25 710 1 Remission remission NN cord-024189-t7mbsr25 710 2 induction induction NN cord-024189-t7mbsr25 710 3 with with IN cord-024189-t7mbsr25 710 4 cyclophosphamide cyclophosphamide NN cord-024189-t7mbsr25 710 5 is be VBZ cord-024189-t7mbsr25 710 6 usually usually RB cord-024189-t7mbsr25 710 7 followed follow VBN cord-024189-t7mbsr25 710 8 by by IN cord-024189-t7mbsr25 710 9 longer long JJR cord-024189-t7mbsr25 710 10 periods period NNS cord-024189-t7mbsr25 710 11 of of IN cord-024189-t7mbsr25 710 12 remission remission NN cord-024189-t7mbsr25 710 13 maintenance maintenance NN cord-024189-t7mbsr25 710 14 therapy therapy NN cord-024189-t7mbsr25 710 15 with with IN cord-024189-t7mbsr25 710 16 either either CC cord-024189-t7mbsr25 710 17 azathioprine azathioprine NN cord-024189-t7mbsr25 710 18 ( ( -LRB- cord-024189-t7mbsr25 710 19 11 11 CD cord-024189-t7mbsr25 710 20 ) ) -RRB- cord-024189-t7mbsr25 710 21 or or CC cord-024189-t7mbsr25 710 22 methotrexate methotrexate NNP cord-024189-t7mbsr25 710 23 ( ( -LRB- cord-024189-t7mbsr25 710 24 21 21 CD cord-024189-t7mbsr25 710 25 ) ) -RRB- cord-024189-t7mbsr25 710 26 . . . cord-024189-t7mbsr25 711 1 For for IN cord-024189-t7mbsr25 711 2 patients patient NNS cord-024189-t7mbsr25 711 3 who who WP cord-024189-t7mbsr25 711 4 demonstrate demonstrate VBP cord-024189-t7mbsr25 711 5 propensities propensity NNS cord-024189-t7mbsr25 711 6 to to IN cord-024189-t7mbsr25 711 7 fl fl NNP cord-024189-t7mbsr25 711 8 are be VBP cord-024189-t7mbsr25 711 9 , , , cord-024189-t7mbsr25 711 10 long long JJ cord-024189-t7mbsr25 711 11 - - HYPH cord-024189-t7mbsr25 711 12 term term NN cord-024189-t7mbsr25 711 13 use use NN cord-024189-t7mbsr25 711 14 of of IN cord-024189-t7mbsr25 711 15 the the DT cord-024189-t7mbsr25 711 16 least least JJS cord-024189-t7mbsr25 711 17 toxic toxic JJ cord-024189-t7mbsr25 711 18 drug drug NN cord-024189-t7mbsr25 711 19 for for IN cord-024189-t7mbsr25 711 20 the the DT cord-024189-t7mbsr25 711 21 maintenance maintenance NN cord-024189-t7mbsr25 711 22 of of IN cord-024189-t7mbsr25 711 23 remission remission NN cord-024189-t7mbsr25 711 24 may may MD cord-024189-t7mbsr25 711 25 be be VB cord-024189-t7mbsr25 711 26 appropriate appropriate JJ cord-024189-t7mbsr25 711 27 . . . cord-024189-t7mbsr25 712 1 This this DT cord-024189-t7mbsr25 712 2 may may MD cord-024189-t7mbsr25 712 3 include include VB cord-024189-t7mbsr25 712 4 methotrexate methotrexate NNP cord-024189-t7mbsr25 712 5 or or CC cord-024189-t7mbsr25 712 6 azathioprine azathioprine NN cord-024189-t7mbsr25 712 7 and and CC cord-024189-t7mbsr25 712 8 , , , cord-024189-t7mbsr25 712 9 for for IN cord-024189-t7mbsr25 712 10 patients patient NNS cord-024189-t7mbsr25 712 11 with with IN cord-024189-t7mbsr25 712 12 recurrent recurrent JJ cord-024189-t7mbsr25 712 13 disease disease NNP cord-024189-t7mbsr25 712 14 fl fl NNP cord-024189-t7mbsr25 712 15 ares ares NNP cord-024189-t7mbsr25 712 16 , , , cord-024189-t7mbsr25 712 17 low low JJ cord-024189-t7mbsr25 712 18 doses dose NNS cord-024189-t7mbsr25 712 19 of of IN cord-024189-t7mbsr25 712 20 prednisone prednisone NNP cord-024189-t7mbsr25 712 21 ( ( -LRB- cord-024189-t7mbsr25 712 22 e.g. e.g. RB cord-024189-t7mbsr25 712 23 , , , cord-024189-t7mbsr25 712 24 5 5 CD cord-024189-t7mbsr25 712 25 mg mg NNP cord-024189-t7mbsr25 712 26 / / SYM cord-024189-t7mbsr25 712 27 day day NN cord-024189-t7mbsr25 712 28 ) ) -RRB- cord-024189-t7mbsr25 712 29 . . . cord-024189-t7mbsr25 713 1 The the DT cord-024189-t7mbsr25 713 2 optimal optimal JJ cord-024189-t7mbsr25 713 3 length length NN cord-024189-t7mbsr25 713 4 of of IN cord-024189-t7mbsr25 713 5 treatment treatment NN cord-024189-t7mbsr25 713 6 with with IN cord-024189-t7mbsr25 713 7 methotrexate methotrexate NNP cord-024189-t7mbsr25 713 8 or or CC cord-024189-t7mbsr25 713 9 azathioprine azathioprine NN cord-024189-t7mbsr25 713 10 is be VBZ cord-024189-t7mbsr25 713 11 not not RB cord-024189-t7mbsr25 713 12 clear clear JJ cord-024189-t7mbsr25 713 13 , , , cord-024189-t7mbsr25 713 14 but but CC cord-024189-t7mbsr25 713 15 continuation continuation NN cord-024189-t7mbsr25 713 16 of of IN cord-024189-t7mbsr25 713 17 these these DT cord-024189-t7mbsr25 713 18 medications medication NNS cord-024189-t7mbsr25 713 19 for for IN cord-024189-t7mbsr25 713 20 at at RB cord-024189-t7mbsr25 713 21 least least RBS cord-024189-t7mbsr25 713 22 1 1 CD cord-024189-t7mbsr25 713 23 year year NN cord-024189-t7mbsr25 713 24 after after IN cord-024189-t7mbsr25 713 25 remission remission NN cord-024189-t7mbsr25 713 26 is be VBZ cord-024189-t7mbsr25 713 27 reasonable reasonable JJ cord-024189-t7mbsr25 713 28 in in IN cord-024189-t7mbsr25 713 29 most most JJS cord-024189-t7mbsr25 713 30 patients patient NNS cord-024189-t7mbsr25 713 31 . . . cord-024189-t7mbsr25 714 1 Tumor tumor NN cord-024189-t7mbsr25 714 2 necrosis necrosis NN cord-024189-t7mbsr25 714 3 factor factor NN cord-024189-t7mbsr25 714 4 inhibition inhibition NN cord-024189-t7mbsr25 714 5 ( ( -LRB- cord-024189-t7mbsr25 714 6 or or CC cord-024189-t7mbsr25 714 7 at at IN cord-024189-t7mbsr25 714 8 least least JJS cord-024189-t7mbsr25 714 9 etanercept etanercept NNP cord-024189-t7mbsr25 714 10 ) ) -RRB- cord-024189-t7mbsr25 714 11 does do VBZ cord-024189-t7mbsr25 714 12 not not RB cord-024189-t7mbsr25 714 13 appear appear VB cord-024189-t7mbsr25 714 14 to to TO cord-024189-t7mbsr25 714 15 be be VB cord-024189-t7mbsr25 714 16 effective effective JJ cord-024189-t7mbsr25 714 17 in in IN cord-024189-t7mbsr25 714 18 WG WG NNP cord-024189-t7mbsr25 714 19 ( ( -LRB- cord-024189-t7mbsr25 714 20 22 22 CD cord-024189-t7mbsr25 714 21 ) ) -RRB- cord-024189-t7mbsr25 714 22 , , , cord-024189-t7mbsr25 714 23 and and CC cord-024189-t7mbsr25 714 24 its -PRON- PRP$ cord-024189-t7mbsr25 714 25 use use NN cord-024189-t7mbsr25 714 26 in in IN cord-024189-t7mbsr25 714 27 combination combination NN cord-024189-t7mbsr25 714 28 with with IN cord-024189-t7mbsr25 714 29 cyclophosphamide cyclophosphamide NN cord-024189-t7mbsr25 714 30 may may MD cord-024189-t7mbsr25 714 31 heighten heighten VB cord-024189-t7mbsr25 714 32 the the DT cord-024189-t7mbsr25 714 33 risk risk NN cord-024189-t7mbsr25 714 34 of of IN cord-024189-t7mbsr25 714 35 solid solid JJ cord-024189-t7mbsr25 714 36 malignancies malignancy NNS cord-024189-t7mbsr25 714 37 substantially substantially RB cord-024189-t7mbsr25 714 38 ( ( -LRB- cord-024189-t7mbsr25 714 39 23 23 CD cord-024189-t7mbsr25 714 40 ) ) -RRB- cord-024189-t7mbsr25 714 41 . . . cord-024189-t7mbsr25 715 1 Among among IN cord-024189-t7mbsr25 715 2 patients patient NNS cord-024189-t7mbsr25 715 3 with with IN cord-024189-t7mbsr25 715 4 limited limited JJ cord-024189-t7mbsr25 715 5 WG WG NNP cord-024189-t7mbsr25 715 6 , , , cord-024189-t7mbsr25 715 7 remission remission NN cord-024189-t7mbsr25 715 8 is be VBZ cord-024189-t7mbsr25 715 9 induced induce VBN cord-024189-t7mbsr25 715 10 in in IN cord-024189-t7mbsr25 715 11 approximately approximately RB cord-024189-t7mbsr25 715 12 three three CD cord-024189-t7mbsr25 715 13 fourths fourth NNS cord-024189-t7mbsr25 715 14 of of IN cord-024189-t7mbsr25 715 15 patients patient NNS cord-024189-t7mbsr25 715 16 with with IN cord-024189-t7mbsr25 715 17 the the DT cord-024189-t7mbsr25 715 18 use use NN cord-024189-t7mbsr25 715 19 of of IN cord-024189-t7mbsr25 715 20 methotrexate methotrexate NNP cord-024189-t7mbsr25 715 21 ( ( -LRB- cord-024189-t7mbsr25 715 22 up up IN cord-024189-t7mbsr25 715 23 to to TO cord-024189-t7mbsr25 715 24 25 25 CD cord-024189-t7mbsr25 715 25 mg mg NNP cord-024189-t7mbsr25 715 26 / / SYM cord-024189-t7mbsr25 715 27 week week NN cord-024189-t7mbsr25 715 28 ) ) -RRB- cord-024189-t7mbsr25 715 29 and and CC cord-024189-t7mbsr25 715 30 glucocorticoids glucocorticoid NNS cord-024189-t7mbsr25 715 31 alone alone RB cord-024189-t7mbsr25 715 32 . . . cord-024189-t7mbsr25 716 1 Patients patient NNS cord-024189-t7mbsr25 716 2 treated treat VBN cord-024189-t7mbsr25 716 3 with with IN cord-024189-t7mbsr25 716 4 methotrexate methotrexate NNP cord-024189-t7mbsr25 716 5 and and CC cord-024189-t7mbsr25 716 6 glucocorticoids glucocorticoid NNS cord-024189-t7mbsr25 716 7 must must MD cord-024189-t7mbsr25 716 8 be be VB cord-024189-t7mbsr25 716 9 observed observe VBN cord-024189-t7mbsr25 716 10 carefully carefully RB cord-024189-t7mbsr25 716 11 for for IN cord-024189-t7mbsr25 716 12 breakthrough breakthrough NN cord-024189-t7mbsr25 716 13 disease disease NN cord-024189-t7mbsr25 716 14 , , , cord-024189-t7mbsr25 716 15 particularly particularly RB cord-024189-t7mbsr25 716 16 glomerulonephritis glomerulonephritis JJ cord-024189-t7mbsr25 716 17 . . . cord-024189-t7mbsr25 717 1 The the DT cord-024189-t7mbsr25 717 2 use use NN cord-024189-t7mbsr25 717 3 of of IN cord-024189-t7mbsr25 717 4 trimethoprim trimethoprim NNP cord-024189-t7mbsr25 717 5 - - HYPH cord-024189-t7mbsr25 717 6 sulfamethoxazole sulfamethoxazole NNP cord-024189-t7mbsr25 717 7 as as IN cord-024189-t7mbsr25 717 8 a a DT cord-024189-t7mbsr25 717 9 treatment treatment NN cord-024189-t7mbsr25 717 10 for for IN cord-024189-t7mbsr25 717 11 WG WG NNP cord-024189-t7mbsr25 717 12 has have VBZ cord-024189-t7mbsr25 717 13 fallen fall VBN cord-024189-t7mbsr25 717 14 increasingly increasingly RB cord-024189-t7mbsr25 717 15 into into IN cord-024189-t7mbsr25 717 16 disfavour disfavour NN cord-024189-t7mbsr25 717 17 . . . cord-024189-t7mbsr25 718 1 The the DT cord-024189-t7mbsr25 718 2 use use NN cord-024189-t7mbsr25 718 3 of of IN cord-024189-t7mbsr25 718 4 trimethoprim trimethoprim NNP cord-024189-t7mbsr25 718 5 - - HYPH cord-024189-t7mbsr25 718 6 sulfamethoxazole sulfamethoxazole NNP cord-024189-t7mbsr25 718 7 alone alone RB cord-024189-t7mbsr25 718 8 for for IN cord-024189-t7mbsr25 718 9 the the DT cord-024189-t7mbsr25 718 10 treatment treatment NN cord-024189-t7mbsr25 718 11 of of IN cord-024189-t7mbsr25 718 12 active active JJ cord-024189-t7mbsr25 718 13 WG WG NNP cord-024189-t7mbsr25 718 14 is be VBZ cord-024189-t7mbsr25 718 15 not not RB cord-024189-t7mbsr25 718 16 appropriate appropriate JJ cord-024189-t7mbsr25 718 17 . . . cord-024189-t7mbsr25 719 1 The the DT cord-024189-t7mbsr25 719 2 medication medication NN cord-024189-t7mbsr25 719 3 may may MD cord-024189-t7mbsr25 719 4 have have VB cord-024189-t7mbsr25 719 5 some some DT cord-024189-t7mbsr25 719 6 role role NN cord-024189-t7mbsr25 719 7 in in IN cord-024189-t7mbsr25 719 8 remission remission NN cord-024189-t7mbsr25 719 9 maintenance maintenance NN cord-024189-t7mbsr25 719 10 for for IN cord-024189-t7mbsr25 719 11 patients patient NNS cord-024189-t7mbsr25 719 12 with with IN cord-024189-t7mbsr25 719 13 upper upper JJ cord-024189-t7mbsr25 719 14 respiratory respiratory JJ cord-024189-t7mbsr25 719 15 tract tract NN cord-024189-t7mbsr25 719 16 disease disease NN cord-024189-t7mbsr25 719 17 , , , cord-024189-t7mbsr25 719 18 however however RB cord-024189-t7mbsr25 719 19 , , , cord-024189-t7mbsr25 719 20 its -PRON- PRP$ cord-024189-t7mbsr25 719 21 effi effi NNP cord-024189-t7mbsr25 719 22 cacy cacy NNP cord-024189-t7mbsr25 719 23 is be VBZ cord-024189-t7mbsr25 719 24 uncertain uncertain JJ cord-024189-t7mbsr25 719 25 and and CC cord-024189-t7mbsr25 719 26 its -PRON- PRP$ cord-024189-t7mbsr25 719 27 mechanism mechanism NN cord-024189-t7mbsr25 719 28 of of IN cord-024189-t7mbsr25 719 29 action action NN cord-024189-t7mbsr25 719 30 unclear unclear JJ cord-024189-t7mbsr25 719 31 . . . cord-024189-t7mbsr25 720 1 A a DT cord-024189-t7mbsr25 720 2 wide wide JJ cord-024189-t7mbsr25 720 3 array array NN cord-024189-t7mbsr25 720 4 of of IN cord-024189-t7mbsr25 720 5 other other JJ cord-024189-t7mbsr25 720 6 therapies therapy NNS cord-024189-t7mbsr25 720 7 , , , cord-024189-t7mbsr25 720 8 such such JJ cord-024189-t7mbsr25 720 9 as as IN cord-024189-t7mbsr25 720 10 plasmapheresis plasmapheresis NN cord-024189-t7mbsr25 720 11 , , , cord-024189-t7mbsr25 720 12 intravenous intravenous JJ cord-024189-t7mbsr25 720 13 immunoglobulin immunoglobulin NN cord-024189-t7mbsr25 720 14 , , , cord-024189-t7mbsr25 720 15 mycophenolate mycophenolate NNP cord-024189-t7mbsr25 720 16 mofetil mofetil NNP cord-024189-t7mbsr25 720 17 , , , cord-024189-t7mbsr25 720 18 and and CC cord-024189-t7mbsr25 720 19 lefl lefl NNP cord-024189-t7mbsr25 720 20 unomide unomide RB cord-024189-t7mbsr25 720 21 , , , cord-024189-t7mbsr25 720 22 have have VBP cord-024189-t7mbsr25 720 23 been be VBN cord-024189-t7mbsr25 720 24 employed employ VBN cord-024189-t7mbsr25 720 25 in in IN cord-024189-t7mbsr25 720 26 small small JJ cord-024189-t7mbsr25 720 27 numbers number NNS cord-024189-t7mbsr25 720 28 of of IN cord-024189-t7mbsr25 720 29 patients patient NNS cord-024189-t7mbsr25 720 30 , , , cord-024189-t7mbsr25 720 31 but but CC cord-024189-t7mbsr25 720 32 so so RB cord-024189-t7mbsr25 720 33 far far RB cord-024189-t7mbsr25 720 34 there there EX cord-024189-t7mbsr25 720 35 are be VBP cord-024189-t7mbsr25 720 36 insuffi insuffi NNP cord-024189-t7mbsr25 720 37 cient cient NNP cord-024189-t7mbsr25 720 38 data data NNP cord-024189-t7mbsr25 720 39 to to TO cord-024189-t7mbsr25 720 40 judge judge VB cord-024189-t7mbsr25 720 41 their -PRON- PRP$ cord-024189-t7mbsr25 720 42 effi effi NNP cord-024189-t7mbsr25 720 43 cacy cacy NN cord-024189-t7mbsr25 720 44 . . . cord-024189-t7mbsr25 721 1 Rituximab rituximab JJ cord-024189-t7mbsr25 721 2 and and CC cord-024189-t7mbsr25 721 3 other other JJ cord-024189-t7mbsr25 721 4 strategies strategy NNS cord-024189-t7mbsr25 721 5 for for IN cord-024189-t7mbsr25 721 6 B b NN cord-024189-t7mbsr25 721 7 - - HYPH cord-024189-t7mbsr25 721 8 cell cell NN cord-024189-t7mbsr25 721 9 depletion depletion NN cord-024189-t7mbsr25 721 10 are be VBP cord-024189-t7mbsr25 721 11 now now RB cord-024189-t7mbsr25 721 12 being be VBG cord-024189-t7mbsr25 721 13 tested test VBN cord-024189-t7mbsr25 721 14 . . . cord-024189-t7mbsr25 722 1 Interferonalpha Interferonalpha NNP cord-024189-t7mbsr25 722 2 has have VBZ cord-024189-t7mbsr25 722 3 been be VBN cord-024189-t7mbsr25 722 4 reported report VBN cord-024189-t7mbsr25 722 5 to to TO cord-024189-t7mbsr25 722 6 have have VB cord-024189-t7mbsr25 722 7 some some DT cord-024189-t7mbsr25 722 8 benefi benefi JJ cord-024189-t7mbsr25 722 9 t t NN cord-024189-t7mbsr25 722 10 for for IN cord-024189-t7mbsr25 722 11 CSS CSS NNP cord-024189-t7mbsr25 722 12 . . . cord-024189-t7mbsr25 723 1 Once once RB cord-024189-t7mbsr25 723 2 scarring scarring NN cord-024189-t7mbsr25 723 3 and and CC cord-024189-t7mbsr25 723 4 fi fi NN cord-024189-t7mbsr25 723 5 brosis brosis NN cord-024189-t7mbsr25 723 6 are be VBP cord-024189-t7mbsr25 723 7 well well RB cord-024189-t7mbsr25 723 8 established establish VBN cord-024189-t7mbsr25 723 9 in in IN cord-024189-t7mbsr25 723 10 the the DT cord-024189-t7mbsr25 723 11 subglottic subglottic JJ cord-024189-t7mbsr25 723 12 region region NN cord-024189-t7mbsr25 723 13 , , , cord-024189-t7mbsr25 723 14 airway airway NN cord-024189-t7mbsr25 723 15 narrowing narrowing NN cord-024189-t7mbsr25 723 16 may may MD cord-024189-t7mbsr25 723 17 be be VB cord-024189-t7mbsr25 723 18 due due JJ cord-024189-t7mbsr25 723 19 to to IN cord-024189-t7mbsr25 723 20 the the DT cord-024189-t7mbsr25 723 21 progression progression NN cord-024189-t7mbsr25 723 22 of of IN cord-024189-t7mbsr25 723 23 scar scar NN cord-024189-t7mbsr25 723 24 tissue tissue NN cord-024189-t7mbsr25 723 25 rather rather RB cord-024189-t7mbsr25 723 26 than than IN cord-024189-t7mbsr25 723 27 to to IN cord-024189-t7mbsr25 723 28 WG WG NNP cord-024189-t7mbsr25 723 29 - - HYPH cord-024189-t7mbsr25 723 30 related relate VBN cord-024189-t7mbsr25 723 31 infl infl NN cord-024189-t7mbsr25 723 32 ammation ammation NN cord-024189-t7mbsr25 723 33 . . . cord-024189-t7mbsr25 724 1 In in IN cord-024189-t7mbsr25 724 2 such such JJ cord-024189-t7mbsr25 724 3 cases case NNS cord-024189-t7mbsr25 724 4 , , , cord-024189-t7mbsr25 724 5 subglottic subglottic JJ cord-024189-t7mbsr25 724 6 stenosis stenosis NN cord-024189-t7mbsr25 724 7 responds respond VBZ cord-024189-t7mbsr25 724 8 poorly poorly RB cord-024189-t7mbsr25 724 9 to to IN cord-024189-t7mbsr25 724 10 immunosuppressive immunosuppressive JJ cord-024189-t7mbsr25 724 11 therapy therapy NN cord-024189-t7mbsr25 724 12 , , , cord-024189-t7mbsr25 724 13 and and CC cord-024189-t7mbsr25 724 14 the the DT cord-024189-t7mbsr25 724 15 most most RBS cord-024189-t7mbsr25 724 16 effective effective JJ cord-024189-t7mbsr25 724 17 therapeutic therapeutic JJ cord-024189-t7mbsr25 724 18 approach approach NN cord-024189-t7mbsr25 724 19 to to IN cord-024189-t7mbsr25 724 20 this this DT cord-024189-t7mbsr25 724 21 problem problem NN cord-024189-t7mbsr25 724 22 is be VBZ cord-024189-t7mbsr25 724 23 laryngoscopic laryngoscopic NNP cord-024189-t7mbsr25 724 24 dilatations dilatation NNS cord-024189-t7mbsr25 724 25 of of IN cord-024189-t7mbsr25 724 26 the the DT cord-024189-t7mbsr25 724 27 airway airway NN cord-024189-t7mbsr25 724 28 , , , cord-024189-t7mbsr25 724 29 augmented augment VBN cord-024189-t7mbsr25 724 30 by by IN cord-024189-t7mbsr25 724 31 intralesional intralesional JJ cord-024189-t7mbsr25 724 32 corticosteroid corticosteroid NN cord-024189-t7mbsr25 724 33 injections injection NNS cord-024189-t7mbsr25 724 34 ( ( -LRB- cord-024189-t7mbsr25 724 35 24 24 CD cord-024189-t7mbsr25 724 36 ) ) -RRB- cord-024189-t7mbsr25 724 37 . . . cord-024189-t7mbsr25 725 1 Serial serial JJ cord-024189-t7mbsr25 725 2 procedures procedure NNS cord-024189-t7mbsr25 725 3 are be VBP cord-024189-t7mbsr25 725 4 often often RB cord-024189-t7mbsr25 725 5 required require VBN cord-024189-t7mbsr25 725 6 . . . cord-024189-t7mbsr25 726 1 If if IN cord-024189-t7mbsr25 726 2 severe severe JJ cord-024189-t7mbsr25 726 3 subglottic subglottic JJ cord-024189-t7mbsr25 726 4 stenosis stenosis NN cord-024189-t7mbsr25 726 5 precludes preclude VBZ cord-024189-t7mbsr25 726 6 a a DT cord-024189-t7mbsr25 726 7 safe safe JJ cord-024189-t7mbsr25 726 8 dilatation dilatation NN cord-024189-t7mbsr25 726 9 procedure procedure NN cord-024189-t7mbsr25 726 10 , , , cord-024189-t7mbsr25 726 11 a a DT cord-024189-t7mbsr25 726 12 patent patent NN cord-024189-t7mbsr25 726 13 airway airway NN cord-024189-t7mbsr25 726 14 should should MD cord-024189-t7mbsr25 726 15 fi fi VB cord-024189-t7mbsr25 726 16 rst rst NNP cord-024189-t7mbsr25 726 17 be be VB cord-024189-t7mbsr25 726 18 secured secure VBN cord-024189-t7mbsr25 726 19 by by IN cord-024189-t7mbsr25 726 20 a a DT cord-024189-t7mbsr25 726 21 tracheostomy tracheostomy NN cord-024189-t7mbsr25 726 22 . . . cord-024189-t7mbsr25 727 1 WG WG NNP cord-024189-t7mbsr25 727 2 often often RB cord-024189-t7mbsr25 727 3 leads lead VBZ cord-024189-t7mbsr25 727 4 to to IN cord-024189-t7mbsr25 727 5 chronic chronic JJ cord-024189-t7mbsr25 727 6 nasosinus nasosinus NNP cord-024189-t7mbsr25 727 7 dysfunction dysfunction NN cord-024189-t7mbsr25 727 8 . . . cord-024189-t7mbsr25 728 1 Regardless regardless RB cord-024189-t7mbsr25 728 2 of of IN cord-024189-t7mbsr25 728 3 disease disease NN cord-024189-t7mbsr25 728 4 activity activity NN cord-024189-t7mbsr25 728 5 , , , cord-024189-t7mbsr25 728 6 most most JJS cord-024189-t7mbsr25 728 7 patients patient NNS cord-024189-t7mbsr25 728 8 require require VBP cord-024189-t7mbsr25 728 9 multiple multiple JJ cord-024189-t7mbsr25 728 10 daily daily JJ cord-024189-t7mbsr25 728 11 saline saline NN cord-024189-t7mbsr25 728 12 irrigations irrigation NNS cord-024189-t7mbsr25 728 13 to to TO cord-024189-t7mbsr25 728 14 minimize minimize VB cord-024189-t7mbsr25 728 15 the the DT cord-024189-t7mbsr25 728 16 accumulation accumulation NN cord-024189-t7mbsr25 728 17 of of IN cord-024189-t7mbsr25 728 18 secretions secretion NNS cord-024189-t7mbsr25 728 19 and and CC cord-024189-t7mbsr25 728 20 crusts crust NNS cord-024189-t7mbsr25 728 21 , , , cord-024189-t7mbsr25 728 22 and and CC cord-024189-t7mbsr25 728 23 to to TO cord-024189-t7mbsr25 728 24 reduce reduce VB cord-024189-t7mbsr25 728 25 the the DT cord-024189-t7mbsr25 728 26 incidence incidence NN cord-024189-t7mbsr25 728 27 of of IN cord-024189-t7mbsr25 728 28 secondary secondary JJ cord-024189-t7mbsr25 728 29 infections infection NNS cord-024189-t7mbsr25 728 30 . . . cord-024189-t7mbsr25 729 1 Persistent persistent JJ cord-024189-t7mbsr25 729 2 or or CC cord-024189-t7mbsr25 729 3 recurrent recurrent JJ cord-024189-t7mbsr25 729 4 infections infection NNS cord-024189-t7mbsr25 729 5 may may MD cord-024189-t7mbsr25 729 6 require require VB cord-024189-t7mbsr25 729 7 surgical surgical JJ cord-024189-t7mbsr25 729 8 drainage drainage NN cord-024189-t7mbsr25 729 9 . . . cord-024189-t7mbsr25 730 1 Distinguishing distinguish VBG cord-024189-t7mbsr25 730 2 between between IN cord-024189-t7mbsr25 730 3 worsening worsen VBG cord-024189-t7mbsr25 730 4 sinus sinus NN cord-024189-t7mbsr25 730 5 disease disease NN cord-024189-t7mbsr25 730 6 caused cause VBN cord-024189-t7mbsr25 730 7 by by IN cord-024189-t7mbsr25 730 8 active active JJ cord-024189-t7mbsr25 730 9 WG WG NNP cord-024189-t7mbsr25 730 10 and and CC cord-024189-t7mbsr25 730 11 superinfection superinfection NN cord-024189-t7mbsr25 730 12 may may MD cord-024189-t7mbsr25 730 13 be be VB cord-024189-t7mbsr25 730 14 diffi diffi NNP cord-024189-t7mbsr25 730 15 cult cult NN cord-024189-t7mbsr25 730 16 . . . cord-024189-t7mbsr25 731 1 In in IN cord-024189-t7mbsr25 731 2 the the DT cord-024189-t7mbsr25 731 3 absence absence NN cord-024189-t7mbsr25 731 4 of of IN cord-024189-t7mbsr25 731 5 a a DT cord-024189-t7mbsr25 731 6 prompt prompt JJ cord-024189-t7mbsr25 731 7 response response NN cord-024189-t7mbsr25 731 8 to to IN cord-024189-t7mbsr25 731 9 antibiotics antibiotic NNS cord-024189-t7mbsr25 731 10 , , , cord-024189-t7mbsr25 731 11 surgical surgical JJ cord-024189-t7mbsr25 731 12 drainage drainage NN cord-024189-t7mbsr25 731 13 and and CC cord-024189-t7mbsr25 731 14 biopsy biopsy NN cord-024189-t7mbsr25 731 15 are be VBP cord-024189-t7mbsr25 731 16 often often RB cord-024189-t7mbsr25 731 17 required require VBN cord-024189-t7mbsr25 731 18 for for IN cord-024189-t7mbsr25 731 19 a a DT cord-024189-t7mbsr25 731 20 more more RBR cord-024189-t7mbsr25 731 21 defi defi JJ cord-024189-t7mbsr25 731 22 nitive nitive JJ cord-024189-t7mbsr25 731 23 diagnosis diagnosis NN cord-024189-t7mbsr25 731 24 . . . cord-024189-t7mbsr25 732 1 In in IN cord-024189-t7mbsr25 732 2 contrast contrast NN cord-024189-t7mbsr25 732 3 to to IN cord-024189-t7mbsr25 732 4 the the DT cord-024189-t7mbsr25 732 5 situation situation NN cord-024189-t7mbsr25 732 6 in in IN cord-024189-t7mbsr25 732 7 the the DT cord-024189-t7mbsr25 732 8 fi fi NN cord-024189-t7mbsr25 732 9 rst rst NNP cord-024189-t7mbsr25 732 10 40 40 CD cord-024189-t7mbsr25 732 11 years year NNS cord-024189-t7mbsr25 732 12 following follow VBG cord-024189-t7mbsr25 732 13 the the DT cord-024189-t7mbsr25 732 14 descriptions description NNS cord-024189-t7mbsr25 732 15 of of IN cord-024189-t7mbsr25 732 16 the the DT cord-024189-t7mbsr25 732 17 AAVs aav NNS cord-024189-t7mbsr25 732 18 , , , cord-024189-t7mbsr25 732 19 these these DT cord-024189-t7mbsr25 732 20 diseases disease NNS cord-024189-t7mbsr25 732 21 are be VBP cord-024189-t7mbsr25 732 22 now now RB cord-024189-t7mbsr25 732 23 highly highly RB cord-024189-t7mbsr25 732 24 treatable treatable JJ cord-024189-t7mbsr25 732 25 . . . cord-024189-t7mbsr25 733 1 Unfortunately unfortunately RB cord-024189-t7mbsr25 733 2 , , , cord-024189-t7mbsr25 733 3 disease disease NN cord-024189-t7mbsr25 733 4 relapses relapse NNS cord-024189-t7mbsr25 733 5 are be VBP cord-024189-t7mbsr25 733 6 a a DT cord-024189-t7mbsr25 733 7 major major JJ cord-024189-t7mbsr25 733 8 threat threat NN cord-024189-t7mbsr25 733 9 . . . cord-024189-t7mbsr25 734 1 MPA MPA NNP cord-024189-t7mbsr25 734 2 and and CC cord-024189-t7mbsr25 734 3 the the DT cord-024189-t7mbsr25 734 4 CSS css NN cord-024189-t7mbsr25 734 5 are be VBP cord-024189-t7mbsr25 734 6 somewhat somewhat RB cord-024189-t7mbsr25 734 7 less less RBR cord-024189-t7mbsr25 734 8 likely likely JJ cord-024189-t7mbsr25 734 9 than than IN cord-024189-t7mbsr25 734 10 WG WG NNP cord-024189-t7mbsr25 734 11 to to IN cord-024189-t7mbsr25 734 12 fl fl NNP cord-024189-t7mbsr25 734 13 are be VBP cord-024189-t7mbsr25 734 14 after after IN cord-024189-t7mbsr25 734 15 the the DT cord-024189-t7mbsr25 734 16 achievement achievement NN cord-024189-t7mbsr25 734 17 of of IN cord-024189-t7mbsr25 734 18 remission remission NN cord-024189-t7mbsr25 734 19 . . . cord-024189-t7mbsr25 735 1 The the DT cord-024189-t7mbsr25 735 2 percentages percentage NNS cord-024189-t7mbsr25 735 3 of of IN cord-024189-t7mbsr25 735 4 patients patient NNS cord-024189-t7mbsr25 735 5 with with IN cord-024189-t7mbsr25 735 6 those those DT cord-024189-t7mbsr25 735 7 diseases disease NNS cord-024189-t7mbsr25 735 8 who who WP cord-024189-t7mbsr25 735 9 suffer suffer VBP cord-024189-t7mbsr25 735 10 disease disease NNP cord-024189-t7mbsr25 735 11 fl fl NNP cord-024189-t7mbsr25 735 12 ares ares NNP cord-024189-t7mbsr25 735 13 after after IN cord-024189-t7mbsr25 735 14 appropriate appropriate JJ cord-024189-t7mbsr25 735 15 courses course NNS cord-024189-t7mbsr25 735 16 of of IN cord-024189-t7mbsr25 735 17 treatment treatment NN cord-024189-t7mbsr25 735 18 have have VBP cord-024189-t7mbsr25 735 19 been be VBN cord-024189-t7mbsr25 735 20 estimated estimate VBN cord-024189-t7mbsr25 735 21 to to TO cord-024189-t7mbsr25 735 22 be be VB cord-024189-t7mbsr25 735 23 about about RB cord-024189-t7mbsr25 735 24 25 25 CD cord-024189-t7mbsr25 735 25 % % NN cord-024189-t7mbsr25 735 26 to to IN cord-024189-t7mbsr25 735 27 40 40 CD cord-024189-t7mbsr25 735 28 % % NN cord-024189-t7mbsr25 735 29 . . . cord-024189-t7mbsr25 736 1 Even even RB cord-024189-t7mbsr25 736 2 with with IN cord-024189-t7mbsr25 736 3 therapy therapy NN cord-024189-t7mbsr25 736 4 , , , cord-024189-t7mbsr25 736 5 mortality mortality NN cord-024189-t7mbsr25 736 6 and and CC cord-024189-t7mbsr25 736 7 morbidity morbidity NN cord-024189-t7mbsr25 736 8 are be VBP cord-024189-t7mbsr25 736 9 substantial substantial JJ cord-024189-t7mbsr25 736 10 . . . cord-024189-t7mbsr25 737 1 In in IN cord-024189-t7mbsr25 737 2 a a DT cord-024189-t7mbsr25 737 3 cohort cohort NN cord-024189-t7mbsr25 737 4 of of IN cord-024189-t7mbsr25 737 5 158 158 CD cord-024189-t7mbsr25 737 6 patients patient NNS cord-024189-t7mbsr25 737 7 followed follow VBD cord-024189-t7mbsr25 737 8 at at IN cord-024189-t7mbsr25 737 9 the the DT cord-024189-t7mbsr25 737 10 National National NNP cord-024189-t7mbsr25 737 11 Institutes Institutes NNPS cord-024189-t7mbsr25 737 12 of of IN cord-024189-t7mbsr25 737 13 Health Health NNP cord-024189-t7mbsr25 737 14 ( ( -LRB- cord-024189-t7mbsr25 737 15 NIH NIH NNP cord-024189-t7mbsr25 737 16 ) ) -RRB- cord-024189-t7mbsr25 737 17 from from IN cord-024189-t7mbsr25 737 18 the the DT cord-024189-t7mbsr25 737 19 late late JJ cord-024189-t7mbsr25 737 20 1960s 1960 NNS cord-024189-t7mbsr25 737 21 through through IN cord-024189-t7mbsr25 737 22 the the DT cord-024189-t7mbsr25 737 23 early early JJ cord-024189-t7mbsr25 737 24 1990s 1990 NNS cord-024189-t7mbsr25 737 25 ( ( -LRB- cord-024189-t7mbsr25 737 26 9 9 CD cord-024189-t7mbsr25 737 27 ) ) -RRB- cord-024189-t7mbsr25 737 28 , , , cord-024189-t7mbsr25 737 29 12 12 CD cord-024189-t7mbsr25 737 30 % % NN cord-024189-t7mbsr25 737 31 of of IN cord-024189-t7mbsr25 737 32 deaths death NNS cord-024189-t7mbsr25 737 33 were be VBD cord-024189-t7mbsr25 737 34 due due JJ cord-024189-t7mbsr25 737 35 to to IN cord-024189-t7mbsr25 737 36 either either CC cord-024189-t7mbsr25 737 37 the the DT cord-024189-t7mbsr25 737 38 disease disease NN cord-024189-t7mbsr25 737 39 or or CC cord-024189-t7mbsr25 737 40 complications complication NNS cord-024189-t7mbsr25 737 41 of of IN cord-024189-t7mbsr25 737 42 treatment treatment NN cord-024189-t7mbsr25 737 43 , , , cord-024189-t7mbsr25 737 44 and and CC cord-024189-t7mbsr25 737 45 86 86 CD cord-024189-t7mbsr25 737 46 % % NN cord-024189-t7mbsr25 737 47 suffered suffer VBD cord-024189-t7mbsr25 737 48 permanent permanent JJ cord-024189-t7mbsr25 737 49 disease disease NN cord-024189-t7mbsr25 737 50 - - HYPH cord-024189-t7mbsr25 737 51 related relate VBN cord-024189-t7mbsr25 737 52 morbidity morbidity NN cord-024189-t7mbsr25 737 53 , , , cord-024189-t7mbsr25 737 54 including include VBG cord-024189-t7mbsr25 737 55 chronic chronic JJ cord-024189-t7mbsr25 737 56 renal renal JJ cord-024189-t7mbsr25 737 57 insuffi insuffi NN cord-024189-t7mbsr25 737 58 ciency ciency NN cord-024189-t7mbsr25 737 59 ( ( -LRB- cord-024189-t7mbsr25 737 60 42 42 CD cord-024189-t7mbsr25 737 61 % % NN cord-024189-t7mbsr25 737 62 ) ) -RRB- cord-024189-t7mbsr25 737 63 , , , cord-024189-t7mbsr25 737 64 end end NN cord-024189-t7mbsr25 737 65 - - HYPH cord-024189-t7mbsr25 737 66 stage stage NN cord-024189-t7mbsr25 737 67 renal renal JJ cord-024189-t7mbsr25 737 68 disease disease NN cord-024189-t7mbsr25 737 69 requiring require VBG cord-024189-t7mbsr25 737 70 dialysis dialysis NN cord-024189-t7mbsr25 737 71 ( ( -LRB- cord-024189-t7mbsr25 737 72 10 10 CD cord-024189-t7mbsr25 737 73 % % NN cord-024189-t7mbsr25 737 74 ) ) -RRB- cord-024189-t7mbsr25 737 75 , , , cord-024189-t7mbsr25 737 76 hearing hear VBG cord-024189-t7mbsr25 737 77 loss loss NN cord-024189-t7mbsr25 737 78 ( ( -LRB- cord-024189-t7mbsr25 737 79 35 35 CD cord-024189-t7mbsr25 737 80 % % NN cord-024189-t7mbsr25 737 81 ) ) -RRB- cord-024189-t7mbsr25 737 82 , , , cord-024189-t7mbsr25 737 83 nasal nasal NN cord-024189-t7mbsr25 737 84 deformity deformity NN cord-024189-t7mbsr25 737 85 ( ( -LRB- cord-024189-t7mbsr25 737 86 28 28 CD cord-024189-t7mbsr25 737 87 % % NN cord-024189-t7mbsr25 737 88 ) ) -RRB- cord-024189-t7mbsr25 737 89 , , , cord-024189-t7mbsr25 737 90 tracheal tracheal JJ cord-024189-t7mbsr25 737 91 stenosis stenosis NN cord-024189-t7mbsr25 737 92 ( ( -LRB- cord-024189-t7mbsr25 737 93 13 13 CD cord-024189-t7mbsr25 737 94 % % NN cord-024189-t7mbsr25 737 95 ) ) -RRB- cord-024189-t7mbsr25 737 96 , , , cord-024189-t7mbsr25 737 97 and and CC cord-024189-t7mbsr25 737 98 visual visual JJ cord-024189-t7mbsr25 737 99 loss loss NN cord-024189-t7mbsr25 737 100 ( ( -LRB- cord-024189-t7mbsr25 737 101 8 8 CD cord-024189-t7mbsr25 737 102 % % NN cord-024189-t7mbsr25 737 103 ) ) -RRB- cord-024189-t7mbsr25 737 104 . . . cord-024189-t7mbsr25 738 1 Many many JJ cord-024189-t7mbsr25 738 2 patients patient NNS cord-024189-t7mbsr25 738 3 incurred incur VBD cord-024189-t7mbsr25 738 4 more more JJR cord-024189-t7mbsr25 738 5 than than IN cord-024189-t7mbsr25 738 6 one one CD cord-024189-t7mbsr25 738 7 type type NN cord-024189-t7mbsr25 738 8 of of IN cord-024189-t7mbsr25 738 9 permanent permanent JJ cord-024189-t7mbsr25 738 10 morbidity morbidity NN cord-024189-t7mbsr25 738 11 . . . cord-024189-t7mbsr25 739 1 In in IN cord-024189-t7mbsr25 739 2 a a DT cord-024189-t7mbsr25 739 3 more more RBR cord-024189-t7mbsr25 739 4 recent recent JJ cord-024189-t7mbsr25 739 5 retrospective retrospective JJ cord-024189-t7mbsr25 739 6 study study NN cord-024189-t7mbsr25 739 7 of of IN cord-024189-t7mbsr25 739 8 246 246 CD cord-024189-t7mbsr25 739 9 patients patient NNS cord-024189-t7mbsr25 739 10 with with IN cord-024189-t7mbsr25 739 11 ANCA ANCA NNP cord-024189-t7mbsr25 739 12 - - HYPH cord-024189-t7mbsr25 739 13 associated associate VBN cord-024189-t7mbsr25 739 14 renal renal JJ cord-024189-t7mbsr25 739 15 vasculitis vasculitis NN cord-024189-t7mbsr25 739 16 ( ( -LRB- cord-024189-t7mbsr25 739 17 25 25 CD cord-024189-t7mbsr25 739 18 ) ) -RRB- cord-024189-t7mbsr25 739 19 , , , cord-024189-t7mbsr25 739 20 cumulative cumulative JJ cord-024189-t7mbsr25 739 21 patient patient JJ cord-024189-t7mbsr25 739 22 survival survival NN cord-024189-t7mbsr25 739 23 at at IN cord-024189-t7mbsr25 739 24 5 5 CD cord-024189-t7mbsr25 739 25 years year NNS cord-024189-t7mbsr25 739 26 was be VBD cord-024189-t7mbsr25 739 27 76 76 CD cord-024189-t7mbsr25 739 28 % % NN cord-024189-t7mbsr25 739 29 . . . cord-024189-t7mbsr25 740 1 There there EX cord-024189-t7mbsr25 740 2 was be VBD cord-024189-t7mbsr25 740 3 an an DT cord-024189-t7mbsr25 740 4 18 18 CD cord-024189-t7mbsr25 740 5 % % NN cord-024189-t7mbsr25 740 6 mortality mortality NN cord-024189-t7mbsr25 740 7 rate rate NN cord-024189-t7mbsr25 740 8 at at IN cord-024189-t7mbsr25 740 9 1 1 CD cord-024189-t7mbsr25 740 10 year year NN cord-024189-t7mbsr25 740 11 , , , cord-024189-t7mbsr25 740 12 however however RB cord-024189-t7mbsr25 740 13 , , , cord-024189-t7mbsr25 740 14 with with IN cord-024189-t7mbsr25 740 15 infections infection NNS cord-024189-t7mbsr25 740 16 as as IN cord-024189-t7mbsr25 740 17 a a DT cord-024189-t7mbsr25 740 18 major major JJ cord-024189-t7mbsr25 740 19 cause cause NN cord-024189-t7mbsr25 740 20 of of IN cord-024189-t7mbsr25 740 21 death death NN cord-024189-t7mbsr25 740 22 . . . cord-024189-t7mbsr25 741 1 In in IN cord-024189-t7mbsr25 741 2 this this DT cord-024189-t7mbsr25 741 3 cohort cohort NN cord-024189-t7mbsr25 741 4 , , , cord-024189-t7mbsr25 741 5 mortality mortality NN cord-024189-t7mbsr25 741 6 was be VBD cord-024189-t7mbsr25 741 7 associated associate VBN cord-024189-t7mbsr25 741 8 with with IN cord-024189-t7mbsr25 741 9 age age NN cord-024189-t7mbsr25 741 10 older old JJR cord-024189-t7mbsr25 741 11 than than IN cord-024189-t7mbsr25 741 12 60 60 CD cord-024189-t7mbsr25 741 13 years year NNS cord-024189-t7mbsr25 741 14 , , , cord-024189-t7mbsr25 741 15 the the DT cord-024189-t7mbsr25 741 16 development development NN cord-024189-t7mbsr25 741 17 of of IN cord-024189-t7mbsr25 741 18 end end NN cord-024189-t7mbsr25 741 19 - - HYPH cord-024189-t7mbsr25 741 20 stage stage NN cord-024189-t7mbsr25 741 21 renal renal JJ cord-024189-t7mbsr25 741 22 failure failure NN cord-024189-t7mbsr25 741 23 , , , cord-024189-t7mbsr25 741 24 and and CC cord-024189-t7mbsr25 741 25 an an DT cord-024189-t7mbsr25 741 26 initial initial JJ cord-024189-t7mbsr25 741 27 serum serum NN cord-024189-t7mbsr25 741 28 creatinine creatinine NN cord-024189-t7mbsr25 741 29 level level NN cord-024189-t7mbsr25 741 30 greater great JJR cord-024189-t7mbsr25 741 31 than than IN cord-024189-t7mbsr25 741 32 2.26 2.26 CD cord-024189-t7mbsr25 742 1 mg mg NNP cord-024189-t7mbsr25 742 2 / / SYM cord-024189-t7mbsr25 742 3 dL. dL. NNP cord-024189-t7mbsr25 743 1 In in IN cord-024189-t7mbsr25 743 2 the the DT cord-024189-t7mbsr25 743 3 Wegener Wegener NNP cord-024189-t7mbsr25 743 4 's 's POS cord-024189-t7mbsr25 743 5 Granulomatosis Granulomatosis NNP cord-024189-t7mbsr25 743 6 Etanercept Etanercept NNP cord-024189-t7mbsr25 743 7 Trial Trial NNP cord-024189-t7mbsr25 743 8 ( ( -LRB- cord-024189-t7mbsr25 743 9 WGET WGET NNP cord-024189-t7mbsr25 743 10 ) ) -RRB- cord-024189-t7mbsr25 743 11 ( ( -LRB- cord-024189-t7mbsr25 743 12 22 22 CD cord-024189-t7mbsr25 743 13 ) ) -RRB- cord-024189-t7mbsr25 743 14 , , , cord-024189-t7mbsr25 743 15 although although IN cord-024189-t7mbsr25 743 16 > > XX cord-024189-t7mbsr25 743 17 90 90 CD cord-024189-t7mbsr25 743 18 % % NN cord-024189-t7mbsr25 743 19 of of IN cord-024189-t7mbsr25 743 20 all all DT cord-024189-t7mbsr25 743 21 patients patient NNS cord-024189-t7mbsr25 743 22 achieved achieve VBN cord-024189-t7mbsr25 743 23 at at IN cord-024189-t7mbsr25 743 24 least least JJS cord-024189-t7mbsr25 743 25 a a DT cord-024189-t7mbsr25 743 26 transient transient JJ cord-024189-t7mbsr25 743 27 disease disease NN cord-024189-t7mbsr25 743 28 activity activity NN cord-024189-t7mbsr25 743 29 score score NN cord-024189-t7mbsr25 743 30 of of IN cord-024189-t7mbsr25 743 31 zero zero CD cord-024189-t7mbsr25 743 32 , , , cord-024189-t7mbsr25 743 33 fewer few JJR cord-024189-t7mbsr25 743 34 than than IN cord-024189-t7mbsr25 743 35 50 50 CD cord-024189-t7mbsr25 743 36 % % NN cord-024189-t7mbsr25 743 37 of of IN cord-024189-t7mbsr25 743 38 patients patient NNS cord-024189-t7mbsr25 743 39 achieved achieve VBN cord-024189-t7mbsr25 743 40 and and CC cord-024189-t7mbsr25 743 41 maintained maintain VBD cord-024189-t7mbsr25 743 42 these these DT cord-024189-t7mbsr25 743 43 disease disease NN cord-024189-t7mbsr25 743 44 remissions remission NNS cord-024189-t7mbsr25 743 45 over over IN cord-024189-t7mbsr25 743 46 the the DT cord-024189-t7mbsr25 743 47 mean mean JJ cord-024189-t7mbsr25 743 48 22-month 22-month JJ cord-024189-t7mbsr25 743 49 course course NN cord-024189-t7mbsr25 743 50 of of IN cord-024189-t7mbsr25 743 51 follow follow NN cord-024189-t7mbsr25 743 52 - - HYPH cord-024189-t7mbsr25 743 53 up up NN cord-024189-t7mbsr25 743 54 on on IN cord-024189-t7mbsr25 743 55 treatment treatment NN cord-024189-t7mbsr25 743 56 . . . cord-024189-t7mbsr25 744 1 Thus thus RB cord-024189-t7mbsr25 744 2 , , , cord-024189-t7mbsr25 744 3 although although IN cord-024189-t7mbsr25 744 4 remissions remission NNS cord-024189-t7mbsr25 744 5 are be VBP cord-024189-t7mbsr25 744 6 achieved achieve VBN cord-024189-t7mbsr25 744 7 in in IN cord-024189-t7mbsr25 744 8 most most JJS cord-024189-t7mbsr25 744 9 patients patient NNS cord-024189-t7mbsr25 744 10 with with IN cord-024189-t7mbsr25 744 11 WG WG NNP cord-024189-t7mbsr25 744 12 , , , cord-024189-t7mbsr25 744 13 relapse relapse NN cord-024189-t7mbsr25 744 14 remains remain VBZ cord-024189-t7mbsr25 744 15 a a DT cord-024189-t7mbsr25 744 16 major major JJ cord-024189-t7mbsr25 744 17 threat threat NN cord-024189-t7mbsr25 744 18 . . . cord-024189-t7mbsr25 745 1 Furthermore furthermore RB cord-024189-t7mbsr25 745 2 , , , cord-024189-t7mbsr25 745 3 89 89 CD cord-024189-t7mbsr25 745 4 % % NN cord-024189-t7mbsr25 745 5 of of IN cord-024189-t7mbsr25 745 6 the the DT cord-024189-t7mbsr25 745 7 patients patient NNS cord-024189-t7mbsr25 745 8 enrolled enrol VBN cord-024189-t7mbsr25 745 9 in in IN cord-024189-t7mbsr25 745 10 the the DT cord-024189-t7mbsr25 745 11 WGET WGET NNP cord-024189-t7mbsr25 745 12 had have VBD cord-024189-t7mbsr25 745 13 sustained sustain VBN cord-024189-t7mbsr25 745 14 at at IN cord-024189-t7mbsr25 745 15 least least RBS cord-024189-t7mbsr25 745 16 one one CD cord-024189-t7mbsr25 745 17 item item NN cord-024189-t7mbsr25 745 18 of of IN cord-024189-t7mbsr25 745 19 damage damage NN cord-024189-t7mbsr25 745 20 from from IN cord-024189-t7mbsr25 745 21 the the DT cord-024189-t7mbsr25 745 22 disease disease NN cord-024189-t7mbsr25 745 23 or or CC cord-024189-t7mbsr25 745 24 treatment treatment NN cord-024189-t7mbsr25 745 25 within within IN cord-024189-t7mbsr25 745 26 1 1 CD cord-024189-t7mbsr25 745 27 year year NN cord-024189-t7mbsr25 745 28 of of IN cord-024189-t7mbsr25 745 29 enrollment enrollment NN cord-024189-t7mbsr25 745 30 ( ( -LRB- cord-024189-t7mbsr25 745 31 26 26 CD cord-024189-t7mbsr25 745 32 ) ) -RRB- cord-024189-t7mbsr25 745 33 . . . cord-024189-t7mbsr25 746 1 The the DT cord-024189-t7mbsr25 746 2 most most RBS cord-024189-t7mbsr25 746 3 common common JJ cord-024189-t7mbsr25 746 4 items item NNS cord-024189-t7mbsr25 746 5 of of IN cord-024189-t7mbsr25 746 6 damage damage NN cord-024189-t7mbsr25 746 7 recorded record VBN cord-024189-t7mbsr25 746 8 were be VBD cord-024189-t7mbsr25 746 9 hearing hear VBG cord-024189-t7mbsr25 746 10 loss loss NN cord-024189-t7mbsr25 746 11 ( ( -LRB- cord-024189-t7mbsr25 746 12 26 26 CD cord-024189-t7mbsr25 746 13 % % NN cord-024189-t7mbsr25 746 14 ) ) -RRB- cord-024189-t7mbsr25 746 15 and and CC cord-024189-t7mbsr25 746 16 proteinuria proteinuria NN cord-024189-t7mbsr25 746 17 ( ( -LRB- cord-024189-t7mbsr25 746 18 19 19 CD cord-024189-t7mbsr25 746 19 % % NN cord-024189-t7mbsr25 746 20 ) ) -RRB- cord-024189-t7mbsr25 746 21 . . . cord-024189-t7mbsr25 747 1 Much much JJ cord-024189-t7mbsr25 747 2 of of IN cord-024189-t7mbsr25 747 3 the the DT cord-024189-t7mbsr25 747 4 morbidity morbidity NN cord-024189-t7mbsr25 747 5 in in IN cord-024189-t7mbsr25 747 6 the the DT cord-024189-t7mbsr25 747 7 AAVs aav NNS cord-024189-t7mbsr25 747 8 relates relate VBZ cord-024189-t7mbsr25 747 9 to to IN cord-024189-t7mbsr25 747 10 prolonged prolong VBN cord-024189-t7mbsr25 747 11 courses course NNS cord-024189-t7mbsr25 747 12 of of IN cord-024189-t7mbsr25 747 13 immunosuppression immunosuppression NN cord-024189-t7mbsr25 747 14 , , , cord-024189-t7mbsr25 747 15 particularly particularly RB cord-024189-t7mbsr25 747 16 the the DT cord-024189-t7mbsr25 747 17 need need NN cord-024189-t7mbsr25 747 18 to to TO cord-024189-t7mbsr25 747 19 re re VB cord-024189-t7mbsr25 747 20 - - VB cord-024189-t7mbsr25 747 21 treat treat JJ cord-024189-t7mbsr25 747 22 patients patient NNS cord-024189-t7mbsr25 747 23 who who WP cord-024189-t7mbsr25 747 24 suffer suffer VBP cord-024189-t7mbsr25 747 25 multiple multiple JJ cord-024189-t7mbsr25 747 26 relapses relapse NNS cord-024189-t7mbsr25 747 27 . . . cord-024189-t7mbsr25 748 1 In in IN cord-024189-t7mbsr25 748 2 the the DT cord-024189-t7mbsr25 748 3 1229 1229 CD cord-024189-t7mbsr25 748 4 patient patient NN cord-024189-t7mbsr25 748 5 - - HYPH cord-024189-t7mbsr25 748 6 years year NNS cord-024189-t7mbsr25 748 7 of of IN cord-024189-t7mbsr25 748 8 follow follow NN cord-024189-t7mbsr25 748 9 - - HYPH cord-024189-t7mbsr25 748 10 up up NN cord-024189-t7mbsr25 748 11 in in IN cord-024189-t7mbsr25 748 12 the the DT cord-024189-t7mbsr25 748 13 NIH NIH NNP cord-024189-t7mbsr25 748 14 series series NN cord-024189-t7mbsr25 748 15 , , , cord-024189-t7mbsr25 748 16 only only RB cord-024189-t7mbsr25 748 17 46 46 CD cord-024189-t7mbsr25 748 18 % % NN cord-024189-t7mbsr25 748 19 of of IN cord-024189-t7mbsr25 748 20 these these DT cord-024189-t7mbsr25 748 21 years year NNS cord-024189-t7mbsr25 748 22 were be VBD cord-024189-t7mbsr25 748 23 spent spend VBN cord-024189-t7mbsr25 748 24 in in IN cord-024189-t7mbsr25 748 25 remission remission NN cord-024189-t7mbsr25 748 26 . . . cord-024189-t7mbsr25 749 1 Serious serious JJ cord-024189-t7mbsr25 749 2 infections infection NNS cord-024189-t7mbsr25 749 3 occurred occur VBD cord-024189-t7mbsr25 749 4 in in IN cord-024189-t7mbsr25 749 5 46 46 CD cord-024189-t7mbsr25 749 6 % % NN cord-024189-t7mbsr25 749 7 . . . cord-024189-t7mbsr25 750 1 Other other JJ cord-024189-t7mbsr25 750 2 morbidities morbidity NNS cord-024189-t7mbsr25 750 3 included include VBD cord-024189-t7mbsr25 750 4 drug drug NN cord-024189-t7mbsr25 750 5 - - HYPH cord-024189-t7mbsr25 750 6 induced induce VBN cord-024189-t7mbsr25 750 7 cystitis cystitis NN cord-024189-t7mbsr25 750 8 caused cause VBN cord-024189-t7mbsr25 750 9 by by IN cord-024189-t7mbsr25 750 10 cyclophosphamide cyclophosphamide NN cord-024189-t7mbsr25 750 11 ( ( -LRB- cord-024189-t7mbsr25 750 12 43 43 CD cord-024189-t7mbsr25 750 13 % % NN cord-024189-t7mbsr25 750 14 ) ) -RRB- cord-024189-t7mbsr25 750 15 , , , cord-024189-t7mbsr25 750 16 increased increase VBN cord-024189-t7mbsr25 750 17 risk risk NN cord-024189-t7mbsr25 750 18 of of IN cord-024189-t7mbsr25 750 19 malignancy malignancy NN cord-024189-t7mbsr25 750 20 ( ( -LRB- cord-024189-t7mbsr25 750 21 particularly particularly RB cord-024189-t7mbsr25 750 22 bladder bladder NN cord-024189-t7mbsr25 750 23 cancer cancer NN cord-024189-t7mbsr25 750 24 , , , cord-024189-t7mbsr25 750 25 leukemia leukemia NN cord-024189-t7mbsr25 750 26 , , , cord-024189-t7mbsr25 750 27 and and CC cord-024189-t7mbsr25 750 28 lymphoma lymphoma NN cord-024189-t7mbsr25 750 29 ) ) -RRB- cord-024189-t7mbsr25 750 30 , , , cord-024189-t7mbsr25 750 31 infertility infertility NN cord-024189-t7mbsr25 750 32 ( ( -LRB- cord-024189-t7mbsr25 750 33 57 57 CD cord-024189-t7mbsr25 750 34 % % NN cord-024189-t7mbsr25 750 35 of of IN cord-024189-t7mbsr25 750 36 women woman NNS cord-024189-t7mbsr25 750 37 with with IN cord-024189-t7mbsr25 750 38 childbearing childbeare VBG cord-024189-t7mbsr25 750 39 potential potential NN cord-024189-t7mbsr25 750 40 ) ) -RRB- cord-024189-t7mbsr25 750 41 , , , cord-024189-t7mbsr25 750 42 and and CC cord-024189-t7mbsr25 750 43 a a DT cord-024189-t7mbsr25 750 44 host host NN cord-024189-t7mbsr25 750 45 of of IN cord-024189-t7mbsr25 750 46 side side NN cord-024189-t7mbsr25 750 47 effects effect NNS cord-024189-t7mbsr25 750 48 related relate VBN cord-024189-t7mbsr25 750 49 to to IN cord-024189-t7mbsr25 750 50 the the DT cord-024189-t7mbsr25 750 51 use use NN cord-024189-t7mbsr25 750 52 of of IN cord-024189-t7mbsr25 750 53 glucocorticoids glucocorticoid NNS cord-024189-t7mbsr25 750 54 . . . cord-024189-t7mbsr25 751 1 Pathogenic pathogenic JJ cord-024189-t7mbsr25 751 2 immune immune JJ cord-024189-t7mbsr25 751 3 complexes complex NNS cord-024189-t7mbsr25 751 4 formed form VBN cord-024189-t7mbsr25 751 5 between between IN cord-024189-t7mbsr25 751 6 antigen antigen NN cord-024189-t7mbsr25 751 7 and and CC cord-024189-t7mbsr25 751 8 antibodies antibody NNS cord-024189-t7mbsr25 751 9 tend tend VBP cord-024189-t7mbsr25 751 10 to to TO cord-024189-t7mbsr25 751 11 occur occur VB cord-024189-t7mbsr25 751 12 during during IN cord-024189-t7mbsr25 751 13 periods period NNS cord-024189-t7mbsr25 751 14 of of IN cord-024189-t7mbsr25 751 15 antigen antigen NN cord-024189-t7mbsr25 751 16 excess excess NN cord-024189-t7mbsr25 751 17 . . . cord-024189-t7mbsr25 752 1 When when WRB cord-024189-t7mbsr25 752 2 the the DT cord-024189-t7mbsr25 752 3 immune immune JJ cord-024189-t7mbsr25 752 4 complexes complex NNS cord-024189-t7mbsr25 752 5 precipitate precipitate VBP cord-024189-t7mbsr25 752 6 into into IN cord-024189-t7mbsr25 752 7 the the DT cord-024189-t7mbsr25 752 8 tissues tissue NNS cord-024189-t7mbsr25 752 9 , , , cord-024189-t7mbsr25 752 10 they -PRON- PRP cord-024189-t7mbsr25 752 11 fi fi VBP cord-024189-t7mbsr25 752 12 x x NN cord-024189-t7mbsr25 752 13 complement complement NN cord-024189-t7mbsr25 752 14 , , , cord-024189-t7mbsr25 752 15 leading lead VBG cord-024189-t7mbsr25 752 16 to to IN cord-024189-t7mbsr25 752 17 an an DT cord-024189-t7mbsr25 752 18 intense intense JJ cord-024189-t7mbsr25 752 19 immune immune JJ cord-024189-t7mbsr25 752 20 reaction reaction NN cord-024189-t7mbsr25 752 21 . . . cord-024189-t7mbsr25 753 1 In in IN cord-024189-t7mbsr25 753 2 immune immune JJ cord-024189-t7mbsr25 753 3 complex complex JJ cord-024189-t7mbsr25 753 4 vasculitis vasculitis NN cord-024189-t7mbsr25 753 5 , , , cord-024189-t7mbsr25 753 6 immune immune JJ cord-024189-t7mbsr25 753 7 complexes complex NNS cord-024189-t7mbsr25 753 8 deposit deposit NN cord-024189-t7mbsr25 753 9 in in IN cord-024189-t7mbsr25 753 10 the the DT cord-024189-t7mbsr25 753 11 vascular vascular JJ cord-024189-t7mbsr25 753 12 endothelium endothelium NN cord-024189-t7mbsr25 753 13 or or CC cord-024189-t7mbsr25 753 14 in in IN cord-024189-t7mbsr25 753 15 capillary capillary JJ cord-024189-t7mbsr25 753 16 beds bed NNS cord-024189-t7mbsr25 753 17 , , , cord-024189-t7mbsr25 753 18 such such JJ cord-024189-t7mbsr25 753 19 as as IN cord-024189-t7mbsr25 753 20 those those DT cord-024189-t7mbsr25 753 21 found find VBN cord-024189-t7mbsr25 753 22 in in IN cord-024189-t7mbsr25 753 23 the the DT cord-024189-t7mbsr25 753 24 skin skin NN cord-024189-t7mbsr25 753 25 , , , cord-024189-t7mbsr25 753 26 kidneys kidney NNS cord-024189-t7mbsr25 753 27 , , , cord-024189-t7mbsr25 753 28 or or CC cord-024189-t7mbsr25 753 29 lungs lung NNS cord-024189-t7mbsr25 753 30 . . . cord-024189-t7mbsr25 754 1 The the DT cord-024189-t7mbsr25 754 2 most most RBS cord-024189-t7mbsr25 754 3 common common JJ cord-024189-t7mbsr25 754 4 skin skin NN cord-024189-t7mbsr25 754 5 manifestation manifestation NN cord-024189-t7mbsr25 754 6 of of IN cord-024189-t7mbsr25 754 7 small small JJ cord-024189-t7mbsr25 754 8 vessel vessel NN cord-024189-t7mbsr25 754 9 vasculitis vasculitis NN cord-024189-t7mbsr25 754 10 is be VBZ cord-024189-t7mbsr25 754 11 palpable palpable JJ cord-024189-t7mbsr25 754 12 purpura purpura NN cord-024189-t7mbsr25 754 13 . . . cord-024189-t7mbsr25 755 1 Hypersensitivity hypersensitivity NN cord-024189-t7mbsr25 755 2 vasculitis vasculitis NN cord-024189-t7mbsr25 755 3 is be VBZ cord-024189-t7mbsr25 755 4 characterized characterize VBN cord-024189-t7mbsr25 755 5 by by IN cord-024189-t7mbsr25 755 6 immune immune JJ cord-024189-t7mbsr25 755 7 complex complex JJ cord-024189-t7mbsr25 755 8 deposition deposition NN cord-024189-t7mbsr25 755 9 in in IN cord-024189-t7mbsr25 755 10 capillaries capillary NNS cord-024189-t7mbsr25 755 11 , , , cord-024189-t7mbsr25 755 12 postcapillary postcapillary NNP cord-024189-t7mbsr25 755 13 venules venule NNS cord-024189-t7mbsr25 755 14 , , , cord-024189-t7mbsr25 755 15 and and CC cord-024189-t7mbsr25 755 16 arterioles arteriole NNS cord-024189-t7mbsr25 755 17 . . . cord-024189-t7mbsr25 756 1 The the DT cord-024189-t7mbsr25 756 2 usual usual JJ cord-024189-t7mbsr25 756 3 causes cause NNS cord-024189-t7mbsr25 756 4 are be VBP cord-024189-t7mbsr25 756 5 either either DT cord-024189-t7mbsr25 756 6 medications medication NNS cord-024189-t7mbsr25 756 7 ( ( -LRB- cord-024189-t7mbsr25 756 8 e.g. e.g. RB cord-024189-t7mbsr25 756 9 , , , cord-024189-t7mbsr25 756 10 penicillins penicillin NNS cord-024189-t7mbsr25 756 11 , , , cord-024189-t7mbsr25 756 12 sulfonamides sulfonamide NNS cord-024189-t7mbsr25 756 13 , , , cord-024189-t7mbsr25 756 14 or or CC cord-024189-t7mbsr25 756 15 cephalosporins cephalosporin NNS cord-024189-t7mbsr25 756 16 ) ) -RRB- cord-024189-t7mbsr25 756 17 or or CC cord-024189-t7mbsr25 756 18 infections infection NNS cord-024189-t7mbsr25 756 19 . . . cord-024189-t7mbsr25 757 1 Cryoglobulinemic cryoglobulinemic JJ cord-024189-t7mbsr25 757 2 vasculitis vasculitis NN cord-024189-t7mbsr25 757 3 is be VBZ cord-024189-t7mbsr25 757 4 usually usually RB cord-024189-t7mbsr25 757 5 caused cause VBN cord-024189-t7mbsr25 757 6 by by IN cord-024189-t7mbsr25 757 7 hepatitis hepatitis NN cord-024189-t7mbsr25 757 8 C C NNP cord-024189-t7mbsr25 757 9 infections infection NNS cord-024189-t7mbsr25 757 10 . . . cord-024189-t7mbsr25 758 1 The the DT cord-024189-t7mbsr25 758 2 antigens antigen NNS cord-024189-t7mbsr25 758 3 involved involve VBN cord-024189-t7mbsr25 758 4 in in IN cord-024189-t7mbsr25 758 5 cryoglobulinemic cryoglobulinemic JJ cord-024189-t7mbsr25 758 6 vasculitis vasculitis NN cord-024189-t7mbsr25 758 7 are be VBP cord-024189-t7mbsr25 758 8 portions portion NNS cord-024189-t7mbsr25 758 9 of of IN cord-024189-t7mbsr25 758 10 the the DT cord-024189-t7mbsr25 758 11 hepatitis hepatitis NN cord-024189-t7mbsr25 758 12 C C NNP cord-024189-t7mbsr25 758 13 virus virus NN cord-024189-t7mbsr25 758 14 ( ( -LRB- cord-024189-t7mbsr25 758 15 HCV HCV NNP cord-024189-t7mbsr25 758 16 ) ) -RRB- cord-024189-t7mbsr25 758 17 virion virion NN cord-024189-t7mbsr25 758 18 . . . cord-024189-t7mbsr25 759 1 The the DT cord-024189-t7mbsr25 759 2 relevant relevant JJ cord-024189-t7mbsr25 759 3 antibodies antibody NNS cord-024189-t7mbsr25 759 4 are be VBP cord-024189-t7mbsr25 759 5 both both DT cord-024189-t7mbsr25 759 6 IgG IgG NNP cord-024189-t7mbsr25 759 7 and and CC cord-024189-t7mbsr25 759 8 IgM IgM NNP cord-024189-t7mbsr25 759 9 , , , cord-024189-t7mbsr25 759 10 leading lead VBG cord-024189-t7mbsr25 759 11 to to IN cord-024189-t7mbsr25 759 12 the the DT cord-024189-t7mbsr25 759 13 designation designation NN cord-024189-t7mbsr25 759 14 " " `` cord-024189-t7mbsr25 759 15 mixed mixed JJ cord-024189-t7mbsr25 759 16 " " '' cord-024189-t7mbsr25 759 17 cryoglobulinemia cryoglobulinemia NN cord-024189-t7mbsr25 759 18 . . . cord-024189-t7mbsr25 760 1 Henoch Henoch NNP cord-024189-t7mbsr25 760 2 - - HYPH cord-024189-t7mbsr25 760 3 Schönlein Schönlein NNP cord-024189-t7mbsr25 760 4 purpura purpura NN cord-024189-t7mbsr25 760 5 is be VBZ cord-024189-t7mbsr25 760 6 associated associate VBN cord-024189-t7mbsr25 760 7 strongly strongly RB cord-024189-t7mbsr25 760 8 with with IN cord-024189-t7mbsr25 760 9 IgA IgA NNP cord-024189-t7mbsr25 760 10 deposition deposition NN cord-024189-t7mbsr25 760 11 within within IN cord-024189-t7mbsr25 760 12 blood blood NN cord-024189-t7mbsr25 760 13 vessel vessel NN cord-024189-t7mbsr25 760 14 walls wall NNS cord-024189-t7mbsr25 760 15 . . . cord-024189-t7mbsr25 761 1 Hypocomplementemic hypocomplementemic JJ cord-024189-t7mbsr25 761 2 urticarial urticarial JJ cord-024189-t7mbsr25 761 3 vasculitis vasculitis NN cord-024189-t7mbsr25 761 4 has have VBZ cord-024189-t7mbsr25 761 5 many many JJ cord-024189-t7mbsr25 761 6 features feature NNS cord-024189-t7mbsr25 761 7 that that WDT cord-024189-t7mbsr25 761 8 overlap overlap VBP cord-024189-t7mbsr25 761 9 with with IN cord-024189-t7mbsr25 761 10 systemic systemic JJ cord-024189-t7mbsr25 761 11 lupus lupus NN cord-024189-t7mbsr25 761 12 erythematosus erythematosus NN cord-024189-t7mbsr25 761 13 . . . cord-024189-t7mbsr25 762 1 Exposure exposure NN cord-024189-t7mbsr25 762 2 to to IN cord-024189-t7mbsr25 762 3 a a DT cord-024189-t7mbsr25 762 4 foreign foreign JJ cord-024189-t7mbsr25 762 5 antigen antigen NN cord-024189-t7mbsr25 762 6 activates activate VBZ cord-024189-t7mbsr25 762 7 an an DT cord-024189-t7mbsr25 762 8 adaptive adaptive JJ cord-024189-t7mbsr25 762 9 immune immune JJ cord-024189-t7mbsr25 762 10 response response NN cord-024189-t7mbsr25 762 11 that that WDT cord-024189-t7mbsr25 762 12 leads lead VBZ cord-024189-t7mbsr25 762 13 to to IN cord-024189-t7mbsr25 762 14 the the DT cord-024189-t7mbsr25 762 15 production production NN cord-024189-t7mbsr25 762 16 of of IN cord-024189-t7mbsr25 762 17 antigen antigen NN cord-024189-t7mbsr25 762 18 - - HYPH cord-024189-t7mbsr25 762 19 specifi specifi VBN cord-024189-t7mbsr25 762 20 c c NN cord-024189-t7mbsr25 762 21 antibodies antibody NNS cord-024189-t7mbsr25 762 22 . . . cord-024189-t7mbsr25 763 1 The the DT cord-024189-t7mbsr25 763 2 combination combination NN cord-024189-t7mbsr25 763 3 of of IN cord-024189-t7mbsr25 763 4 antibody antibody NN cord-024189-t7mbsr25 763 5 with with IN cord-024189-t7mbsr25 763 6 antigen antigen NN cord-024189-t7mbsr25 763 7 creates create VBZ cord-024189-t7mbsr25 763 8 immune immune JJ cord-024189-t7mbsr25 763 9 complexes complex NNS cord-024189-t7mbsr25 763 10 that that WDT cord-024189-t7mbsr25 763 11 neutralize neutralize VBP cord-024189-t7mbsr25 763 12 the the DT cord-024189-t7mbsr25 763 13 foreign foreign JJ cord-024189-t7mbsr25 763 14 antigen antigen NN cord-024189-t7mbsr25 763 15 , , , cord-024189-t7mbsr25 763 16 and and CC cord-024189-t7mbsr25 763 17 allow allow VB cord-024189-t7mbsr25 763 18 it -PRON- PRP cord-024189-t7mbsr25 763 19 to to TO cord-024189-t7mbsr25 763 20 be be VB cord-024189-t7mbsr25 763 21 cleared clear VBN cord-024189-t7mbsr25 763 22 safely safely RB cord-024189-t7mbsr25 763 23 by by IN cord-024189-t7mbsr25 763 24 the the DT cord-024189-t7mbsr25 763 25 reticuloendothelial reticuloendothelial JJ cord-024189-t7mbsr25 763 26 system system NN cord-024189-t7mbsr25 763 27 . . . cord-024189-t7mbsr25 764 1 This this DT cord-024189-t7mbsr25 764 2 complex complex JJ cord-024189-t7mbsr25 764 3 system system NN cord-024189-t7mbsr25 764 4 , , , cord-024189-t7mbsr25 764 5 however however RB cord-024189-t7mbsr25 764 6 , , , cord-024189-t7mbsr25 764 7 contains contain VBZ cord-024189-t7mbsr25 764 8 within within IN cord-024189-t7mbsr25 764 9 it -PRON- PRP cord-024189-t7mbsr25 764 10 the the DT cord-024189-t7mbsr25 764 11 potential potential NN cord-024189-t7mbsr25 764 12 for for IN cord-024189-t7mbsr25 764 13 failure failure NN cord-024189-t7mbsr25 764 14 . . . cord-024189-t7mbsr25 765 1 If if IN cord-024189-t7mbsr25 765 2 the the DT cord-024189-t7mbsr25 765 3 antibody antibody NN cord-024189-t7mbsr25 765 4 response response NN cord-024189-t7mbsr25 765 5 is be VBZ cord-024189-t7mbsr25 765 6 just just RB cord-024189-t7mbsr25 765 7 right right JJ cord-024189-t7mbsr25 765 8 , , , cord-024189-t7mbsr25 765 9 these these DT cord-024189-t7mbsr25 765 10 immune immune JJ cord-024189-t7mbsr25 765 11 complexes complex NNS cord-024189-t7mbsr25 765 12 may may MD cord-024189-t7mbsr25 765 13 escape escape VB cord-024189-t7mbsr25 765 14 early early JJ cord-024189-t7mbsr25 765 15 detection detection NN cord-024189-t7mbsr25 765 16 , , , cord-024189-t7mbsr25 765 17 and and CC cord-024189-t7mbsr25 765 18 instead instead RB cord-024189-t7mbsr25 765 19 imbed imbed VB cord-024189-t7mbsr25 765 20 themselves -PRON- PRP cord-024189-t7mbsr25 765 21 into into IN cord-024189-t7mbsr25 765 22 joints joint NNS cord-024189-t7mbsr25 765 23 and and CC cord-024189-t7mbsr25 765 24 blood blood NN cord-024189-t7mbsr25 765 25 vessels vessel NNS cord-024189-t7mbsr25 765 26 . . . cord-024189-t7mbsr25 766 1 These these DT cord-024189-t7mbsr25 766 2 immune immune JJ cord-024189-t7mbsr25 766 3 complexes complex NNS cord-024189-t7mbsr25 766 4 can can MD cord-024189-t7mbsr25 766 5 then then RB cord-024189-t7mbsr25 766 6 activate activate VB cord-024189-t7mbsr25 766 7 complement complement NN cord-024189-t7mbsr25 766 8 , , , cord-024189-t7mbsr25 766 9 leading lead VBG cord-024189-t7mbsr25 766 10 to to IN cord-024189-t7mbsr25 766 11 local local JJ cord-024189-t7mbsr25 766 12 infl infl NN cord-024189-t7mbsr25 766 13 ammation ammation NN cord-024189-t7mbsr25 766 14 . . . cord-024189-t7mbsr25 767 1 Immune immune JJ cord-024189-t7mbsr25 767 2 complexes complex NNS cord-024189-t7mbsr25 767 3 deposited deposit VBN cord-024189-t7mbsr25 767 4 in in IN cord-024189-t7mbsr25 767 5 the the DT cord-024189-t7mbsr25 767 6 kidneys kidney NNS cord-024189-t7mbsr25 767 7 , , , cord-024189-t7mbsr25 767 8 for for IN cord-024189-t7mbsr25 767 9 example example NN cord-024189-t7mbsr25 767 10 , , , cord-024189-t7mbsr25 767 11 create create VB cord-024189-t7mbsr25 767 12 glomerulonephritis glomerulonephritis NN cord-024189-t7mbsr25 767 13 ( ( -LRB- cord-024189-t7mbsr25 767 14 1 1 CD cord-024189-t7mbsr25 767 15 ) ) -RRB- cord-024189-t7mbsr25 767 16 . . . cord-024189-t7mbsr25 768 1 Those those DT cord-024189-t7mbsr25 768 2 deposited deposit VBN cord-024189-t7mbsr25 768 3 in in IN cord-024189-t7mbsr25 768 4 the the DT cord-024189-t7mbsr25 768 5 synovium synovium NN cord-024189-t7mbsr25 768 6 lead lead NN cord-024189-t7mbsr25 768 7 to to IN cord-024189-t7mbsr25 768 8 arthritis arthritis NN cord-024189-t7mbsr25 768 9 . . . cord-024189-t7mbsr25 769 1 If if IN cord-024189-t7mbsr25 769 2 the the DT cord-024189-t7mbsr25 769 3 immune immune JJ cord-024189-t7mbsr25 769 4 complexes complex NNS cord-024189-t7mbsr25 769 5 are be VBP cord-024189-t7mbsr25 769 6 found find VBN cord-024189-t7mbsr25 769 7 in in IN cord-024189-t7mbsr25 769 8 the the DT cord-024189-t7mbsr25 769 9 blood blood NN cord-024189-t7mbsr25 769 10 vessels vessel NNS cord-024189-t7mbsr25 769 11 , , , cord-024189-t7mbsr25 769 12 vasculitis vasculitis NN cord-024189-t7mbsr25 769 13 is be VBZ cord-024189-t7mbsr25 769 14 the the DT cord-024189-t7mbsr25 769 15 result result NN cord-024189-t7mbsr25 769 16 . . . cord-024189-t7mbsr25 770 1 In in IN cord-024189-t7mbsr25 770 2 pathology pathology NN cord-024189-t7mbsr25 770 3 , , , cord-024189-t7mbsr25 770 4 the the DT cord-024189-t7mbsr25 770 5 word word NN cord-024189-t7mbsr25 770 6 vasculitis vasculitis NN cord-024189-t7mbsr25 770 7 describes describe VBZ cord-024189-t7mbsr25 770 8 infl infl NN cord-024189-t7mbsr25 770 9 ammation ammation NN cord-024189-t7mbsr25 770 10 within within IN cord-024189-t7mbsr25 770 11 blood blood NN cord-024189-t7mbsr25 770 12 vessel vessel NN cord-024189-t7mbsr25 770 13 walls wall NNS cord-024189-t7mbsr25 770 14 . . . cord-024189-t7mbsr25 771 1 This this DT cord-024189-t7mbsr25 771 2 process process NN cord-024189-t7mbsr25 771 3 frequently frequently RB cord-024189-t7mbsr25 771 4 leads lead VBZ cord-024189-t7mbsr25 771 5 to to IN cord-024189-t7mbsr25 771 6 cellular cellular JJ cord-024189-t7mbsr25 771 7 destruction destruction NN cord-024189-t7mbsr25 771 8 , , , cord-024189-t7mbsr25 771 9 damage damage NN cord-024189-t7mbsr25 771 10 to to IN cord-024189-t7mbsr25 771 11 the the DT cord-024189-t7mbsr25 771 12 vascular vascular JJ cord-024189-t7mbsr25 771 13 structures structure NNS cord-024189-t7mbsr25 771 14 , , , cord-024189-t7mbsr25 771 15 and and CC cord-024189-t7mbsr25 771 16 compromise compromise NN cord-024189-t7mbsr25 771 17 of of IN cord-024189-t7mbsr25 771 18 blood blood NN cord-024189-t7mbsr25 771 19 fl fl NNP cord-024189-t7mbsr25 771 20 ow ow NN cord-024189-t7mbsr25 771 21 to to IN cord-024189-t7mbsr25 771 22 organs organ NNS cord-024189-t7mbsr25 771 23 supplied supply VBN cord-024189-t7mbsr25 771 24 by by IN cord-024189-t7mbsr25 771 25 the the DT cord-024189-t7mbsr25 771 26 involved involve VBN cord-024189-t7mbsr25 771 27 vessels vessel NNS cord-024189-t7mbsr25 771 28 , , , cord-024189-t7mbsr25 771 29 resulting result VBG cord-024189-t7mbsr25 771 30 in in IN cord-024189-t7mbsr25 771 31 organ organ NN cord-024189-t7mbsr25 771 32 compromise compromise NN cord-024189-t7mbsr25 771 33 . . . cord-024189-t7mbsr25 772 1 Several several JJ cord-024189-t7mbsr25 772 2 forms form NNS cord-024189-t7mbsr25 772 3 of of IN cord-024189-t7mbsr25 772 4 vasculitis vasculitis NN cord-024189-t7mbsr25 772 5 are be VBP cord-024189-t7mbsr25 772 6 the the DT cord-024189-t7mbsr25 772 7 direct direct JJ cord-024189-t7mbsr25 772 8 result result NN cord-024189-t7mbsr25 772 9 of of IN cord-024189-t7mbsr25 772 10 immune immune JJ cord-024189-t7mbsr25 772 11 complex complex JJ cord-024189-t7mbsr25 772 12 deposition deposition NN cord-024189-t7mbsr25 772 13 . . . cord-024189-t7mbsr25 773 1 This this DT cord-024189-t7mbsr25 773 2 chapter chapter NN cord-024189-t7mbsr25 773 3 outlines outline VBZ cord-024189-t7mbsr25 773 4 several several JJ cord-024189-t7mbsr25 773 5 examples example NNS cord-024189-t7mbsr25 773 6 of of IN cord-024189-t7mbsr25 773 7 immune immune JJ cord-024189-t7mbsr25 773 8 complex complex NN cord-024189-t7mbsr25 773 9 - - HYPH cord-024189-t7mbsr25 773 10 mediated mediate VBN cord-024189-t7mbsr25 773 11 vasculitis vasculitis NN cord-024189-t7mbsr25 773 12 and and CC cord-024189-t7mbsr25 773 13 highlights highlight VBZ cord-024189-t7mbsr25 773 14 some some DT cord-024189-t7mbsr25 773 15 common common JJ cord-024189-t7mbsr25 773 16 themes theme NNS cord-024189-t7mbsr25 773 17 . . . cord-024189-t7mbsr25 774 1 In in IN cord-024189-t7mbsr25 774 2 1903 1903 CD cord-024189-t7mbsr25 774 3 , , , cord-024189-t7mbsr25 774 4 Maurice Maurice NNP cord-024189-t7mbsr25 774 5 Arthus Arthus NNP cord-024189-t7mbsr25 774 6 noted note VBD cord-024189-t7mbsr25 774 7 that that IN cord-024189-t7mbsr25 774 8 intradermal intradermal JJ cord-024189-t7mbsr25 774 9 injection injection NN cord-024189-t7mbsr25 774 10 of of IN cord-024189-t7mbsr25 774 11 a a DT cord-024189-t7mbsr25 774 12 rabbit rabbit NN cord-024189-t7mbsr25 774 13 with with IN cord-024189-t7mbsr25 774 14 horse horse NN cord-024189-t7mbsr25 774 15 serum serum NN cord-024189-t7mbsr25 774 16 resulted result VBD cord-024189-t7mbsr25 774 17 in in IN cord-024189-t7mbsr25 774 18 a a DT cord-024189-t7mbsr25 774 19 cutaneous cutaneous JJ cord-024189-t7mbsr25 774 20 infl infl NN cord-024189-t7mbsr25 774 21 ammatory ammatory NNP cord-024189-t7mbsr25 774 22 reaction reaction NN cord-024189-t7mbsr25 774 23 that that WDT cord-024189-t7mbsr25 774 24 evolved evolve VBD cord-024189-t7mbsr25 774 25 into into IN cord-024189-t7mbsr25 774 26 localized localized JJ cord-024189-t7mbsr25 774 27 tissue tissue NN cord-024189-t7mbsr25 774 28 necrosis necrosis NN cord-024189-t7mbsr25 774 29 ( ( -LRB- cord-024189-t7mbsr25 774 30 2 2 CD cord-024189-t7mbsr25 774 31 ) ) -RRB- cord-024189-t7mbsr25 774 32 . . . cord-024189-t7mbsr25 775 1 The the DT cord-024189-t7mbsr25 775 2 reaction reaction NN cord-024189-t7mbsr25 775 3 was be VBD cord-024189-t7mbsr25 775 4 faster fast JJR cord-024189-t7mbsr25 775 5 , , , cord-024189-t7mbsr25 775 6 he -PRON- PRP cord-024189-t7mbsr25 775 7 observed observe VBD cord-024189-t7mbsr25 775 8 , , , cord-024189-t7mbsr25 775 9 if if IN cord-024189-t7mbsr25 775 10 the the DT cord-024189-t7mbsr25 775 11 animal animal NN cord-024189-t7mbsr25 775 12 had have VBD cord-024189-t7mbsr25 775 13 been be VBN cord-024189-t7mbsr25 775 14 previously previously RB cord-024189-t7mbsr25 775 15 exposed expose VBN cord-024189-t7mbsr25 775 16 to to IN cord-024189-t7mbsr25 775 17 horse horse NN cord-024189-t7mbsr25 775 18 serum serum NN cord-024189-t7mbsr25 775 19 . . . cord-024189-t7mbsr25 776 1 This this DT cord-024189-t7mbsr25 776 2 response response NN cord-024189-t7mbsr25 776 3 , , , cord-024189-t7mbsr25 776 4 now now RB cord-024189-t7mbsr25 776 5 known know VBN cord-024189-t7mbsr25 776 6 as as IN cord-024189-t7mbsr25 776 7 the the DT cord-024189-t7mbsr25 776 8 Arthus Arthus NNP cord-024189-t7mbsr25 776 9 reaction reaction NN cord-024189-t7mbsr25 776 10 , , , cord-024189-t7mbsr25 776 11 forms form VBZ cord-024189-t7mbsr25 776 12 the the DT cord-024189-t7mbsr25 776 13 basis basis NN cord-024189-t7mbsr25 776 14 of of IN cord-024189-t7mbsr25 776 15 our -PRON- PRP$ cord-024189-t7mbsr25 776 16 understanding understanding NN cord-024189-t7mbsr25 776 17 of of IN cord-024189-t7mbsr25 776 18 immune immune JJ cord-024189-t7mbsr25 776 19 complexmediated complexmediate VBN cord-024189-t7mbsr25 776 20 diseases disease NNS cord-024189-t7mbsr25 776 21 . . . cord-024189-t7mbsr25 777 1 In in IN cord-024189-t7mbsr25 777 2 the the DT cord-024189-t7mbsr25 777 3 Arthus Arthus NNP cord-024189-t7mbsr25 777 4 model model NN cord-024189-t7mbsr25 777 5 , , , cord-024189-t7mbsr25 777 6 injection injection NN cord-024189-t7mbsr25 777 7 of of IN cord-024189-t7mbsr25 777 8 the the DT cord-024189-t7mbsr25 777 9 horse horse NN cord-024189-t7mbsr25 777 10 serum serum NN cord-024189-t7mbsr25 777 11 leads lead VBZ cord-024189-t7mbsr25 777 12 to to IN cord-024189-t7mbsr25 777 13 immune immune VB cord-024189-t7mbsr25 777 14 complex complex JJ cord-024189-t7mbsr25 777 15 formation formation NN cord-024189-t7mbsr25 777 16 that that WDT cord-024189-t7mbsr25 777 17 initiates initiate VBZ cord-024189-t7mbsr25 777 18 complement complement JJ cord-024189-t7mbsr25 777 19 activation activation NN cord-024189-t7mbsr25 777 20 and and CC cord-024189-t7mbsr25 777 21 an an DT cord-024189-t7mbsr25 777 22 infl infl NN cord-024189-t7mbsr25 777 23 ux ux NN cord-024189-t7mbsr25 777 24 of of IN cord-024189-t7mbsr25 777 25 infl infl NNP cord-024189-t7mbsr25 777 26 ammatory ammatory NNP cord-024189-t7mbsr25 777 27 cells cell NNS cord-024189-t7mbsr25 777 28 . . . cord-024189-t7mbsr25 778 1 In in IN cord-024189-t7mbsr25 778 2 the the DT cord-024189-t7mbsr25 778 3 areas area NNS cord-024189-t7mbsr25 778 4 of of IN cord-024189-t7mbsr25 778 5 most most RBS cord-024189-t7mbsr25 778 6 intense intense JJ cord-024189-t7mbsr25 778 7 infl infl NN cord-024189-t7mbsr25 778 8 ammation ammation NN cord-024189-t7mbsr25 778 9 , , , cord-024189-t7mbsr25 778 10 in in IN cord-024189-t7mbsr25 778 11 situ situ JJ cord-024189-t7mbsr25 778 12 thrombosis thrombosis NN cord-024189-t7mbsr25 778 13 formation formation NN cord-024189-t7mbsr25 778 14 can can MD cord-024189-t7mbsr25 778 15 lead lead VB cord-024189-t7mbsr25 778 16 to to IN cord-024189-t7mbsr25 778 17 tissue tissue NN cord-024189-t7mbsr25 778 18 ischemia ischemia NN cord-024189-t7mbsr25 778 19 and and CC cord-024189-t7mbsr25 778 20 hemorrhagic hemorrhagic JJ cord-024189-t7mbsr25 778 21 infarction infarction NN cord-024189-t7mbsr25 778 22 . . . cord-024189-t7mbsr25 779 1 In in IN cord-024189-t7mbsr25 779 2 general general JJ cord-024189-t7mbsr25 779 3 , , , cord-024189-t7mbsr25 779 4 immune immune JJ cord-024189-t7mbsr25 779 5 complexes complex NNS cord-024189-t7mbsr25 779 6 are be VBP cord-024189-t7mbsr25 779 7 not not RB cord-024189-t7mbsr25 779 8 pathogenic pathogenic JJ cord-024189-t7mbsr25 779 9 . . . cord-024189-t7mbsr25 780 1 Their -PRON- PRP$ cord-024189-t7mbsr25 780 2 immunogenicity immunogenicity NN cord-024189-t7mbsr25 780 3 is be VBZ cord-024189-t7mbsr25 780 4 governed govern VBN cord-024189-t7mbsr25 780 5 by by IN cord-024189-t7mbsr25 780 6 a a DT cord-024189-t7mbsr25 780 7 large large JJ cord-024189-t7mbsr25 780 8 number number NN cord-024189-t7mbsr25 780 9 of of IN cord-024189-t7mbsr25 780 10 factors factor NNS cord-024189-t7mbsr25 780 11 , , , cord-024189-t7mbsr25 780 12 including include VBG cord-024189-t7mbsr25 780 13 antigen antigen NN cord-024189-t7mbsr25 780 14 load load NN cord-024189-t7mbsr25 780 15 , , , cord-024189-t7mbsr25 780 16 antibody antibody NN cord-024189-t7mbsr25 780 17 response response NN cord-024189-t7mbsr25 780 18 , , , cord-024189-t7mbsr25 780 19 the the DT cord-024189-t7mbsr25 780 20 effi effi NNP cord-024189-t7mbsr25 780 21 ciency ciency NNP cord-024189-t7mbsr25 780 22 of of IN cord-024189-t7mbsr25 780 23 the the DT cord-024189-t7mbsr25 780 24 reticuloendothelial reticuloendothelial JJ cord-024189-t7mbsr25 780 25 system system NN cord-024189-t7mbsr25 780 26 in in IN cord-024189-t7mbsr25 780 27 the the DT cord-024189-t7mbsr25 780 28 clear clear JJ cord-024189-t7mbsr25 780 29 - - HYPH cord-024189-t7mbsr25 780 30 ance ance NN cord-024189-t7mbsr25 780 31 of of IN cord-024189-t7mbsr25 780 32 immune immune JJ cord-024189-t7mbsr25 780 33 complexes complex NNS cord-024189-t7mbsr25 780 34 , , , cord-024189-t7mbsr25 780 35 physical physical JJ cord-024189-t7mbsr25 780 36 properties property NNS cord-024189-t7mbsr25 780 37 of of IN cord-024189-t7mbsr25 780 38 the the DT cord-024189-t7mbsr25 780 39 blood blood NN cord-024189-t7mbsr25 780 40 vessels vessel NNS cord-024189-t7mbsr25 780 41 ( ( -LRB- cord-024189-t7mbsr25 780 42 including include VBG cord-024189-t7mbsr25 780 43 fl fl NNP cord-024189-t7mbsr25 780 44 ow ow NNP cord-024189-t7mbsr25 780 45 dynamics dynamic NNS cord-024189-t7mbsr25 780 46 and and CC cord-024189-t7mbsr25 780 47 previous previous JJ cord-024189-t7mbsr25 780 48 endothelial endothelial JJ cord-024189-t7mbsr25 780 49 damage damage NN cord-024189-t7mbsr25 780 50 ) ) -RRB- cord-024189-t7mbsr25 780 51 , , , cord-024189-t7mbsr25 780 52 and and CC cord-024189-t7mbsr25 780 53 the the DT cord-024189-t7mbsr25 780 54 solubility solubility NN cord-024189-t7mbsr25 780 55 of of IN cord-024189-t7mbsr25 780 56 the the DT cord-024189-t7mbsr25 780 57 immune immune JJ cord-024189-t7mbsr25 780 58 complexes complex NNS cord-024189-t7mbsr25 780 59 themselves -PRON- PRP cord-024189-t7mbsr25 780 60 . . . cord-024189-t7mbsr25 781 1 Immune immune JJ cord-024189-t7mbsr25 781 2 complex complex JJ cord-024189-t7mbsr25 781 3 solubility solubility NN cord-024189-t7mbsr25 781 4 is be VBZ cord-024189-t7mbsr25 781 5 determined determine VBN cord-024189-t7mbsr25 781 6 by by IN cord-024189-t7mbsr25 781 7 the the DT cord-024189-t7mbsr25 781 8 ratio ratio NN cord-024189-t7mbsr25 781 9 of of IN cord-024189-t7mbsr25 781 10 antibody antibody NN cord-024189-t7mbsr25 781 11 to to IN cord-024189-t7mbsr25 781 12 antigen antigen NNP cord-024189-t7mbsr25 781 13 . . . cord-024189-t7mbsr25 782 1 When when WRB cord-024189-t7mbsr25 782 2 antibody antibody NN cord-024189-t7mbsr25 782 3 and and CC cord-024189-t7mbsr25 782 4 antigen antigen NN cord-024189-t7mbsr25 782 5 are be VBP cord-024189-t7mbsr25 782 6 present present JJ cord-024189-t7mbsr25 782 7 in in IN cord-024189-t7mbsr25 782 8 equal equal JJ cord-024189-t7mbsr25 782 9 proportion proportion NN cord-024189-t7mbsr25 782 10 , , , cord-024189-t7mbsr25 782 11 large large JJ cord-024189-t7mbsr25 782 12 immune immune JJ cord-024189-t7mbsr25 782 13 complexes complex NNS cord-024189-t7mbsr25 782 14 are be VBP cord-024189-t7mbsr25 782 15 formed form VBN cord-024189-t7mbsr25 782 16 , , , cord-024189-t7mbsr25 782 17 which which WDT cord-024189-t7mbsr25 782 18 are be VBP cord-024189-t7mbsr25 782 19 identifi identifi VBN cord-024189-t7mbsr25 782 20 ed ed NNP cord-024189-t7mbsr25 782 21 easily easily RB cord-024189-t7mbsr25 782 22 and and CC cord-024189-t7mbsr25 782 23 removed remove VBN cord-024189-t7mbsr25 782 24 by by IN cord-024189-t7mbsr25 782 25 the the DT cord-024189-t7mbsr25 782 26 reticuloendothelial reticuloendothelial JJ cord-024189-t7mbsr25 782 27 system system NN cord-024189-t7mbsr25 782 28 . . . cord-024189-t7mbsr25 783 1 When when WRB cord-024189-t7mbsr25 783 2 there there EX cord-024189-t7mbsr25 783 3 is be VBZ cord-024189-t7mbsr25 783 4 an an DT cord-024189-t7mbsr25 783 5 excess excess NN cord-024189-t7mbsr25 783 6 of of IN cord-024189-t7mbsr25 783 7 antibody antibody NN cord-024189-t7mbsr25 783 8 , , , cord-024189-t7mbsr25 783 9 small small JJ cord-024189-t7mbsr25 783 10 immune immune JJ cord-024189-t7mbsr25 783 11 complexes complex NNS cord-024189-t7mbsr25 783 12 are be VBP cord-024189-t7mbsr25 783 13 formed form VBN cord-024189-t7mbsr25 783 14 , , , cord-024189-t7mbsr25 783 15 which which WDT cord-024189-t7mbsr25 783 16 remain remain VBP cord-024189-t7mbsr25 783 17 in in IN cord-024189-t7mbsr25 783 18 solution solution NN cord-024189-t7mbsr25 783 19 , , , cord-024189-t7mbsr25 783 20 and and CC cord-024189-t7mbsr25 783 21 do do VBP cord-024189-t7mbsr25 783 22 not not RB cord-024189-t7mbsr25 783 23 elicit elicit VB cord-024189-t7mbsr25 783 24 an an DT cord-024189-t7mbsr25 783 25 immune immune JJ cord-024189-t7mbsr25 783 26 response response NN cord-024189-t7mbsr25 783 27 . . . cord-024189-t7mbsr25 784 1 When when WRB cord-024189-t7mbsr25 784 2 there there EX cord-024189-t7mbsr25 784 3 is be VBZ cord-024189-t7mbsr25 784 4 a a DT cord-024189-t7mbsr25 784 5 slight slight JJ cord-024189-t7mbsr25 784 6 excess excess NN cord-024189-t7mbsr25 784 7 of of IN cord-024189-t7mbsr25 784 8 antigen antigen NN cord-024189-t7mbsr25 784 9 , , , cord-024189-t7mbsr25 784 10 however however RB cord-024189-t7mbsr25 784 11 , , , cord-024189-t7mbsr25 784 12 the the DT cord-024189-t7mbsr25 784 13 immune immune JJ cord-024189-t7mbsr25 784 14 complexes complex NNS cord-024189-t7mbsr25 784 15 precipitate precipitate VBP cord-024189-t7mbsr25 784 16 from from IN cord-024189-t7mbsr25 784 17 solution solution NN cord-024189-t7mbsr25 784 18 , , , cord-024189-t7mbsr25 784 19 and and CC cord-024189-t7mbsr25 784 20 become become VB cord-024189-t7mbsr25 784 21 trapped trap VBN cord-024189-t7mbsr25 784 22 in in IN cord-024189-t7mbsr25 784 23 characteristic characteristic JJ cord-024189-t7mbsr25 784 24 areas- areas- NN cord-024189-t7mbsr25 785 1 either either CC cord-024189-t7mbsr25 785 2 the the DT cord-024189-t7mbsr25 785 3 capillary capillary JJ cord-024189-t7mbsr25 785 4 beds bed NNS cord-024189-t7mbsr25 785 5 ( ( -LRB- cord-024189-t7mbsr25 785 6 such such JJ cord-024189-t7mbsr25 785 7 as as IN cord-024189-t7mbsr25 785 8 those those DT cord-024189-t7mbsr25 785 9 found find VBN cord-024189-t7mbsr25 785 10 in in IN cord-024189-t7mbsr25 785 11 the the DT cord-024189-t7mbsr25 785 12 skin skin NN cord-024189-t7mbsr25 785 13 , , , cord-024189-t7mbsr25 785 14 kidneys kidney NNS cord-024189-t7mbsr25 785 15 , , , cord-024189-t7mbsr25 785 16 or or CC cord-024189-t7mbsr25 785 17 lungs lung NNS cord-024189-t7mbsr25 785 18 ) ) -RRB- cord-024189-t7mbsr25 785 19 , , , cord-024189-t7mbsr25 785 20 or or CC cord-024189-t7mbsr25 785 21 the the DT cord-024189-t7mbsr25 785 22 endothelium endothelium NN cord-024189-t7mbsr25 785 23 of of IN cord-024189-t7mbsr25 785 24 medium medium JJ cord-024189-t7mbsr25 785 25 - - HYPH cord-024189-t7mbsr25 785 26 sized sized JJ cord-024189-t7mbsr25 785 27 blood blood NN cord-024189-t7mbsr25 785 28 vessels vessel NNS cord-024189-t7mbsr25 785 29 previously previously RB cord-024189-t7mbsr25 785 30 damaged damage VBN cord-024189-t7mbsr25 785 31 by by IN cord-024189-t7mbsr25 785 32 turbulent turbulent JJ cord-024189-t7mbsr25 785 33 blood blood NN cord-024189-t7mbsr25 785 34 fl fl NNP cord-024189-t7mbsr25 785 35 ow ow UH cord-024189-t7mbsr25 785 36 . . . cord-024189-t7mbsr25 786 1 When when WRB cord-024189-t7mbsr25 786 2 the the DT cord-024189-t7mbsr25 786 3 immune immune JJ cord-024189-t7mbsr25 786 4 complexes complex NNS cord-024189-t7mbsr25 786 5 precipitate precipitate VBP cord-024189-t7mbsr25 786 6 into into IN cord-024189-t7mbsr25 786 7 the the DT cord-024189-t7mbsr25 786 8 tissues tissue NNS cord-024189-t7mbsr25 786 9 , , , cord-024189-t7mbsr25 786 10 they -PRON- PRP cord-024189-t7mbsr25 786 11 fi fi VBP cord-024189-t7mbsr25 786 12 x x NN cord-024189-t7mbsr25 786 13 complement complement NN cord-024189-t7mbsr25 786 14 , , , cord-024189-t7mbsr25 786 15 leading lead VBG cord-024189-t7mbsr25 786 16 to to IN cord-024189-t7mbsr25 786 17 an an DT cord-024189-t7mbsr25 786 18 intense intense JJ cord-024189-t7mbsr25 786 19 immune immune JJ cord-024189-t7mbsr25 786 20 reaction reaction NN cord-024189-t7mbsr25 786 21 . . . cord-024189-t7mbsr25 787 1 Complement complement NN cord-024189-t7mbsr25 787 2 fi fi NN cord-024189-t7mbsr25 787 3 xation xation NN cord-024189-t7mbsr25 787 4 and and CC cord-024189-t7mbsr25 787 5 local local JJ cord-024189-t7mbsr25 787 6 infl infl NN cord-024189-t7mbsr25 787 7 ammation ammation NNP cord-024189-t7mbsr25 787 8 recruit recruit VBP cord-024189-t7mbsr25 787 9 neutrophils neutrophil NNS cord-024189-t7mbsr25 787 10 , , , cord-024189-t7mbsr25 787 11 which which WDT cord-024189-t7mbsr25 787 12 attempt attempt VBP cord-024189-t7mbsr25 787 13 to to TO cord-024189-t7mbsr25 787 14 engulf engulf VB cord-024189-t7mbsr25 787 15 the the DT cord-024189-t7mbsr25 787 16 immune immune JJ cord-024189-t7mbsr25 787 17 complexes complex NNS cord-024189-t7mbsr25 787 18 . . . cord-024189-t7mbsr25 788 1 During during IN cord-024189-t7mbsr25 788 2 this this DT cord-024189-t7mbsr25 788 3 process process NN cord-024189-t7mbsr25 788 4 , , , cord-024189-t7mbsr25 788 5 the the DT cord-024189-t7mbsr25 788 6 neutrophils neutrophil NNS cord-024189-t7mbsr25 788 7 degranulate degranulate NNP cord-024189-t7mbsr25 788 8 , , , cord-024189-t7mbsr25 788 9 releasing release VBG cord-024189-t7mbsr25 788 10 lysosomal lysosomal JJ cord-024189-t7mbsr25 788 11 enzymes enzyme NNS cord-024189-t7mbsr25 788 12 and and CC cord-024189-t7mbsr25 788 13 oxygen oxygen NN cord-024189-t7mbsr25 788 14 free free JJ cord-024189-t7mbsr25 788 15 radicals radical NNS cord-024189-t7mbsr25 788 16 that that WDT cord-024189-t7mbsr25 788 17 cause cause VBP cord-024189-t7mbsr25 788 18 tissue tissue NN cord-024189-t7mbsr25 788 19 necrosis necrosis NN cord-024189-t7mbsr25 788 20 . . . cord-024189-t7mbsr25 789 1 The the DT cord-024189-t7mbsr25 789 2 inciting incite VBG cord-024189-t7mbsr25 789 3 antigen antigen NN cord-024189-t7mbsr25 789 4 can can MD cord-024189-t7mbsr25 789 5 be be VB cord-024189-t7mbsr25 789 6 from from IN cord-024189-t7mbsr25 789 7 numerous numerous JJ cord-024189-t7mbsr25 789 8 sources source NNS cord-024189-t7mbsr25 789 9 . . . cord-024189-t7mbsr25 790 1 In in IN cord-024189-t7mbsr25 790 2 infective infective JJ cord-024189-t7mbsr25 790 3 endocarditis endocarditis NN cord-024189-t7mbsr25 790 4 , , , cord-024189-t7mbsr25 790 5 the the DT cord-024189-t7mbsr25 790 6 antibody antibody NN cord-024189-t7mbsr25 790 7 response response NN cord-024189-t7mbsr25 790 8 , , , cord-024189-t7mbsr25 790 9 formed form VBN cord-024189-t7mbsr25 790 10 against against IN cord-024189-t7mbsr25 790 11 bacterial bacterial JJ cord-024189-t7mbsr25 790 12 antigens antigen NNS cord-024189-t7mbsr25 790 13 , , , cord-024189-t7mbsr25 790 14 can can MD cord-024189-t7mbsr25 790 15 lead lead VB cord-024189-t7mbsr25 790 16 to to IN cord-024189-t7mbsr25 790 17 painful painful JJ cord-024189-t7mbsr25 790 18 cutaneous cutaneous JJ cord-024189-t7mbsr25 790 19 lesions lesion NNS cord-024189-t7mbsr25 790 20 known know VBN cord-024189-t7mbsr25 790 21 as as IN cord-024189-t7mbsr25 790 22 Osler Osler NNP cord-024189-t7mbsr25 790 23 nodes node NNS cord-024189-t7mbsr25 790 24 . . . cord-024189-t7mbsr25 791 1 In in IN cord-024189-t7mbsr25 791 2 systemic systemic JJ cord-024189-t7mbsr25 791 3 lupus lupus NN cord-024189-t7mbsr25 791 4 erythematosus erythematosus NN cord-024189-t7mbsr25 791 5 ( ( -LRB- cord-024189-t7mbsr25 791 6 SLE SLE NNP cord-024189-t7mbsr25 791 7 ) ) -RRB- cord-024189-t7mbsr25 791 8 , , , cord-024189-t7mbsr25 791 9 antibodies antibody NNS cord-024189-t7mbsr25 791 10 form form VBP cord-024189-t7mbsr25 791 11 against against IN cord-024189-t7mbsr25 791 12 nuclear nuclear JJ cord-024189-t7mbsr25 791 13 components component NNS cord-024189-t7mbsr25 791 14 ( ( -LRB- cord-024189-t7mbsr25 791 15 e.g. e.g. RB cord-024189-t7mbsr25 791 16 , , , cord-024189-t7mbsr25 791 17 DNA dna NN cord-024189-t7mbsr25 791 18 and and CC cord-024189-t7mbsr25 791 19 histones histone NNS cord-024189-t7mbsr25 791 20 ) ) -RRB- cord-024189-t7mbsr25 791 21 that that WDT cord-024189-t7mbsr25 791 22 are be VBP cord-024189-t7mbsr25 791 23 released release VBN cord-024189-t7mbsr25 791 24 during during IN cord-024189-t7mbsr25 791 25 tissue tissue NN cord-024189-t7mbsr25 791 26 injury injury NN cord-024189-t7mbsr25 791 27 . . . cord-024189-t7mbsr25 792 1 Certain certain JJ cord-024189-t7mbsr25 792 2 forms form NNS cord-024189-t7mbsr25 792 3 of of IN cord-024189-t7mbsr25 792 4 malignancy malignancy NN cord-024189-t7mbsr25 792 5 can can MD cord-024189-t7mbsr25 792 6 be be VB cord-024189-t7mbsr25 792 7 associated associate VBN cord-024189-t7mbsr25 792 8 with with IN cord-024189-t7mbsr25 792 9 immune immune JJ cord-024189-t7mbsr25 792 10 complex complex JJ cord-024189-t7mbsr25 792 11 formation formation NN cord-024189-t7mbsr25 792 12 , , , cord-024189-t7mbsr25 792 13 with with IN cord-024189-t7mbsr25 792 14 antibodies antibody NNS cord-024189-t7mbsr25 792 15 directed direct VBN cord-024189-t7mbsr25 792 16 against against IN cord-024189-t7mbsr25 792 17 tumor tumor NN cord-024189-t7mbsr25 792 18 - - HYPH cord-024189-t7mbsr25 792 19 associated associate VBN cord-024189-t7mbsr25 792 20 antigens antigen NNS cord-024189-t7mbsr25 792 21 . . . cord-024189-t7mbsr25 793 1 Immune immune JJ cord-024189-t7mbsr25 793 2 complexes complex NNS cord-024189-t7mbsr25 793 3 may may MD cord-024189-t7mbsr25 793 4 also also RB cord-024189-t7mbsr25 793 5 form form VB cord-024189-t7mbsr25 793 6 in in IN cord-024189-t7mbsr25 793 7 response response NN cord-024189-t7mbsr25 793 8 to to IN cord-024189-t7mbsr25 793 9 a a DT cord-024189-t7mbsr25 793 10 large large JJ cord-024189-t7mbsr25 793 11 number number NN cord-024189-t7mbsr25 793 12 of of IN cord-024189-t7mbsr25 793 13 drugs drug NNS cord-024189-t7mbsr25 793 14 , , , cord-024189-t7mbsr25 793 15 including include VBG cord-024189-t7mbsr25 793 16 penicillin penicillin NN cord-024189-t7mbsr25 793 17 and and CC cord-024189-t7mbsr25 793 18 sulfonamides sulfonamide NNS cord-024189-t7mbsr25 793 19 . . . cord-024189-t7mbsr25 794 1 Hypersensitivity hypersensitivity NN cord-024189-t7mbsr25 794 2 reactions reaction NNS cord-024189-t7mbsr25 794 3 were be VBD cord-024189-t7mbsr25 794 4 fi fi NNP cord-024189-t7mbsr25 794 5 rst rst NNP cord-024189-t7mbsr25 794 6 noted note VBN cord-024189-t7mbsr25 794 7 in in IN cord-024189-t7mbsr25 794 8 patients patient NNS cord-024189-t7mbsr25 794 9 who who WP cord-024189-t7mbsr25 794 10 were be VBD cord-024189-t7mbsr25 794 11 treated treat VBN cord-024189-t7mbsr25 794 12 with with IN cord-024189-t7mbsr25 794 13 antitoxin antitoxin NN cord-024189-t7mbsr25 794 14 derived derive VBN cord-024189-t7mbsr25 794 15 from from IN cord-024189-t7mbsr25 794 16 horse horse NN cord-024189-t7mbsr25 794 17 serum serum NN cord-024189-t7mbsr25 794 18 . . . cord-024189-t7mbsr25 795 1 Such such JJ cord-024189-t7mbsr25 795 2 patients patient NNS cord-024189-t7mbsr25 795 3 developed develop VBD cord-024189-t7mbsr25 795 4 an an DT cord-024189-t7mbsr25 795 5 antibody antibody NN cord-024189-t7mbsr25 795 6 response response NN cord-024189-t7mbsr25 795 7 to to IN cord-024189-t7mbsr25 795 8 the the DT cord-024189-t7mbsr25 795 9 horse horse NN cord-024189-t7mbsr25 795 10 antigens antigen NNS cord-024189-t7mbsr25 795 11 , , , cord-024189-t7mbsr25 795 12 which which WDT cord-024189-t7mbsr25 795 13 led lead VBD cord-024189-t7mbsr25 795 14 to to IN cord-024189-t7mbsr25 795 15 a a DT cord-024189-t7mbsr25 795 16 characteristic characteristic JJ cord-024189-t7mbsr25 795 17 syndrome syndrome NN cord-024189-t7mbsr25 795 18 of of IN cord-024189-t7mbsr25 795 19 fever fever NN cord-024189-t7mbsr25 795 20 , , , cord-024189-t7mbsr25 795 21 joint joint JJ cord-024189-t7mbsr25 795 22 pain pain NN cord-024189-t7mbsr25 795 23 , , , cord-024189-t7mbsr25 795 24 and and CC cord-024189-t7mbsr25 795 25 rash rash JJ cord-024189-t7mbsr25 795 26 now now RB cord-024189-t7mbsr25 795 27 known know VBN cord-024189-t7mbsr25 795 28 as as IN cord-024189-t7mbsr25 795 29 serum serum NN cord-024189-t7mbsr25 795 30 sickness sickness NN cord-024189-t7mbsr25 795 31 . . . cord-024189-t7mbsr25 796 1 Hypersensitivity hypersensitivity NN cord-024189-t7mbsr25 796 2 vasculitis vasculitis NN cord-024189-t7mbsr25 796 3 refers refer VBZ cord-024189-t7mbsr25 796 4 to to IN cord-024189-t7mbsr25 796 5 a a DT cord-024189-t7mbsr25 796 6 heterogeneous heterogeneous JJ cord-024189-t7mbsr25 796 7 group group NN cord-024189-t7mbsr25 796 8 of of IN cord-024189-t7mbsr25 796 9 syndromes syndrome NNS cord-024189-t7mbsr25 796 10 ( ( -LRB- cord-024189-t7mbsr25 796 11 including include VBG cord-024189-t7mbsr25 796 12 serum serum NN cord-024189-t7mbsr25 796 13 sickness sickness NN cord-024189-t7mbsr25 796 14 and and CC cord-024189-t7mbsr25 796 15 druginduced druginduced JJ cord-024189-t7mbsr25 796 16 vasculitis vasculitis NN cord-024189-t7mbsr25 796 17 ) ) -RRB- cord-024189-t7mbsr25 796 18 characterized characterize VBN cord-024189-t7mbsr25 796 19 by by IN cord-024189-t7mbsr25 796 20 immune immune JJ cord-024189-t7mbsr25 796 21 complex complex JJ cord-024189-t7mbsr25 796 22 deposition deposition NN cord-024189-t7mbsr25 796 23 in in IN cord-024189-t7mbsr25 796 24 capillaries capillary NNS cord-024189-t7mbsr25 796 25 , , , cord-024189-t7mbsr25 796 26 postcapillary postcapillary NNP cord-024189-t7mbsr25 796 27 venules venule NNS cord-024189-t7mbsr25 796 28 , , , cord-024189-t7mbsr25 796 29 and and CC cord-024189-t7mbsr25 796 30 arterioles arteriole NNS cord-024189-t7mbsr25 796 31 . . . cord-024189-t7mbsr25 797 1 This this DT cord-024189-t7mbsr25 797 2 is be VBZ cord-024189-t7mbsr25 797 3 the the DT cord-024189-t7mbsr25 797 4 most most RBS cord-024189-t7mbsr25 797 5 common common JJ cord-024189-t7mbsr25 797 6 form form NN cord-024189-t7mbsr25 797 7 of of IN cord-024189-t7mbsr25 797 8 vasculitis vasculitis NN cord-024189-t7mbsr25 797 9 . . . cord-024189-t7mbsr25 798 1 Although although IN cord-024189-t7mbsr25 798 2 multiple multiple JJ cord-024189-t7mbsr25 798 3 agents agent NNS cord-024189-t7mbsr25 798 4 have have VBP cord-024189-t7mbsr25 798 5 been be VBN cord-024189-t7mbsr25 798 6 implicated implicate VBN cord-024189-t7mbsr25 798 7 , , , cord-024189-t7mbsr25 798 8 including include VBG cord-024189-t7mbsr25 798 9 penicillins penicillin NNS cord-024189-t7mbsr25 798 10 , , , cord-024189-t7mbsr25 798 11 sulfonamides sulfonamide NNS cord-024189-t7mbsr25 798 12 , , , cord-024189-t7mbsr25 798 13 and and CC cord-024189-t7mbsr25 798 14 cephalosporins cephalosporin NNS cord-024189-t7mbsr25 798 15 , , , cord-024189-t7mbsr25 798 16 the the DT cord-024189-t7mbsr25 798 17 inciting incite VBG cord-024189-t7mbsr25 798 18 agent agent NN cord-024189-t7mbsr25 798 19 can can MD cord-024189-t7mbsr25 798 20 not not RB cord-024189-t7mbsr25 798 21 always always RB cord-024189-t7mbsr25 798 22 be be VB cord-024189-t7mbsr25 798 23 identifi identifi VBN cord-024189-t7mbsr25 798 24 ed ed NNP cord-024189-t7mbsr25 798 25 . . . cord-024189-t7mbsr25 799 1 The the DT cord-024189-t7mbsr25 799 2 presence presence NN cord-024189-t7mbsr25 799 3 of of IN cord-024189-t7mbsr25 799 4 three three CD cord-024189-t7mbsr25 799 5 or or CC cord-024189-t7mbsr25 799 6 more more JJR cord-024189-t7mbsr25 799 7 criteria criterion NNS cord-024189-t7mbsr25 799 8 has have VBZ cord-024189-t7mbsr25 799 9 a a DT cord-024189-t7mbsr25 799 10 sensitivity sensitivity NN cord-024189-t7mbsr25 799 11 of of IN cord-024189-t7mbsr25 799 12 71 71 CD cord-024189-t7mbsr25 799 13 % % NN cord-024189-t7mbsr25 799 14 and and CC cord-024189-t7mbsr25 799 15 specifi specifi NN cord-024189-t7mbsr25 799 16 city city NN cord-024189-t7mbsr25 799 17 of of IN cord-024189-t7mbsr25 799 18 84 84 CD cord-024189-t7mbsr25 799 19 % % NN cord-024189-t7mbsr25 799 20 for for IN cord-024189-t7mbsr25 799 21 the the DT cord-024189-t7mbsr25 799 22 diagnosis diagnosis NN cord-024189-t7mbsr25 799 23 of of IN cord-024189-t7mbsr25 799 24 hypersensitivity hypersensitivity NN cord-024189-t7mbsr25 799 25 vasculitis vasculitis NN cord-024189-t7mbsr25 799 26 . . . cord-024189-t7mbsr25 800 1 Hypersensitivity hypersensitivity NN cord-024189-t7mbsr25 800 2 vasculitis vasculitis NN cord-024189-t7mbsr25 800 3 that that WDT cord-024189-t7mbsr25 800 4 occurs occur VBZ cord-024189-t7mbsr25 800 5 without without IN cord-024189-t7mbsr25 800 6 systemic systemic JJ cord-024189-t7mbsr25 800 7 manifestations manifestation NNS cord-024189-t7mbsr25 800 8 is be VBZ cord-024189-t7mbsr25 800 9 sometimes sometimes RB cord-024189-t7mbsr25 800 10 referred refer VBN cord-024189-t7mbsr25 800 11 to to IN cord-024189-t7mbsr25 800 12 as as RB cord-024189-t7mbsr25 800 13 cutaneous cutaneous JJ cord-024189-t7mbsr25 800 14 vasculitis vasculitis NN cord-024189-t7mbsr25 800 15 or or CC cord-024189-t7mbsr25 800 16 cutaneous cutaneous JJ cord-024189-t7mbsr25 800 17 leukocytoclastic leukocytoclastic JJ cord-024189-t7mbsr25 800 18 angiitis angiitis RB cord-024189-t7mbsr25 800 19 . . . cord-024189-t7mbsr25 801 1 The the DT cord-024189-t7mbsr25 801 2 term term NN cord-024189-t7mbsr25 801 3 serum serum NN cord-024189-t7mbsr25 801 4 sickness sickness NN cord-024189-t7mbsr25 801 5 , , , cord-024189-t7mbsr25 801 6 on on IN cord-024189-t7mbsr25 801 7 the the DT cord-024189-t7mbsr25 801 8 other other JJ cord-024189-t7mbsr25 801 9 hand hand NN cord-024189-t7mbsr25 801 10 , , , cord-024189-t7mbsr25 801 11 is be VBZ cord-024189-t7mbsr25 801 12 reserved reserve VBN cord-024189-t7mbsr25 801 13 to to TO cord-024189-t7mbsr25 801 14 describe describe VB cord-024189-t7mbsr25 801 15 a a DT cord-024189-t7mbsr25 801 16 systemic systemic JJ cord-024189-t7mbsr25 801 17 illness illness NN cord-024189-t7mbsr25 801 18 , , , cord-024189-t7mbsr25 801 19 including include VBG cord-024189-t7mbsr25 801 20 rash rash JJ cord-024189-t7mbsr25 801 21 and and CC cord-024189-t7mbsr25 801 22 arthralgias arthralgias NNP cord-024189-t7mbsr25 801 23 , , , cord-024189-t7mbsr25 801 24 which which WDT cord-024189-t7mbsr25 801 25 occurs occur VBZ cord-024189-t7mbsr25 801 26 1 1 CD cord-024189-t7mbsr25 801 27 to to IN cord-024189-t7mbsr25 801 28 2 2 CD cord-024189-t7mbsr25 801 29 weeks week NNS cord-024189-t7mbsr25 801 30 after after IN cord-024189-t7mbsr25 801 31 exposure exposure NN cord-024189-t7mbsr25 801 32 to to IN cord-024189-t7mbsr25 801 33 a a DT cord-024189-t7mbsr25 801 34 drug drug NN cord-024189-t7mbsr25 801 35 or or CC cord-024189-t7mbsr25 801 36 foreign foreign JJ cord-024189-t7mbsr25 801 37 antigen antigen NN cord-024189-t7mbsr25 801 38 . . . cord-024189-t7mbsr25 802 1 Most Most JJS cord-024189-t7mbsr25 802 2 patients patient NNS cord-024189-t7mbsr25 802 3 with with IN cord-024189-t7mbsr25 802 4 hypersensitivity hypersensitivity NN cord-024189-t7mbsr25 802 5 vasculitis vasculitis NN cord-024189-t7mbsr25 802 6 will will MD cord-024189-t7mbsr25 802 7 develop develop VB cord-024189-t7mbsr25 802 8 cutaneous cutaneous JJ cord-024189-t7mbsr25 802 9 manifestations manifestation NNS cord-024189-t7mbsr25 802 10 , , , cord-024189-t7mbsr25 802 11 the the DT cord-024189-t7mbsr25 802 12 most most RBS cord-024189-t7mbsr25 802 13 common common JJ cord-024189-t7mbsr25 802 14 of of IN cord-024189-t7mbsr25 802 15 which which WDT cord-024189-t7mbsr25 802 16 is be VBZ cord-024189-t7mbsr25 802 17 purpura purpura NN cord-024189-t7mbsr25 802 18 ( ( -LRB- cord-024189-t7mbsr25 802 19 Figure figure NN cord-024189-t7mbsr25 802 20 21D-1 21d-1 CD cord-024189-t7mbsr25 802 21 ) ) -RRB- cord-024189-t7mbsr25 802 22 . . . cord-024189-t7mbsr25 803 1 These these DT cord-024189-t7mbsr25 803 2 lesions lesion NNS cord-024189-t7mbsr25 803 3 are be VBP cord-024189-t7mbsr25 803 4 distributed distribute VBN cord-024189-t7mbsr25 803 5 usually usually RB cord-024189-t7mbsr25 803 6 in in IN cord-024189-t7mbsr25 803 7 a a DT cord-024189-t7mbsr25 803 8 symmetric symmetric JJ cord-024189-t7mbsr25 803 9 fashion fashion NN cord-024189-t7mbsr25 803 10 over over IN cord-024189-t7mbsr25 803 11 dependent dependent JJ cord-024189-t7mbsr25 803 12 regions region NNS cord-024189-t7mbsr25 803 13 of of IN cord-024189-t7mbsr25 803 14 the the DT cord-024189-t7mbsr25 803 15 body body NN cord-024189-t7mbsr25 803 16 , , , cord-024189-t7mbsr25 803 17 particularly particularly RB cord-024189-t7mbsr25 803 18 the the DT cord-024189-t7mbsr25 803 19 lower low JJR cord-024189-t7mbsr25 803 20 legs leg NNS cord-024189-t7mbsr25 803 21 ( ( -LRB- cord-024189-t7mbsr25 803 22 and and CC cord-024189-t7mbsr25 803 23 , , , cord-024189-t7mbsr25 803 24 in in IN cord-024189-t7mbsr25 803 25 recumbent recumbent JJ cord-024189-t7mbsr25 803 26 patients patient NNS cord-024189-t7mbsr25 803 27 , , , cord-024189-t7mbsr25 803 28 over over IN cord-024189-t7mbsr25 803 29 the the DT cord-024189-t7mbsr25 803 30 buttocks buttock NNS cord-024189-t7mbsr25 803 31 ) ) -RRB- cord-024189-t7mbsr25 803 32 because because IN cord-024189-t7mbsr25 803 33 of of IN cord-024189-t7mbsr25 803 34 the the DT cord-024189-t7mbsr25 803 35 increased increase VBN cord-024189-t7mbsr25 803 36 hydrostatic hydrostatic JJ cord-024189-t7mbsr25 803 37 pressure pressure NN cord-024189-t7mbsr25 803 38 in in IN cord-024189-t7mbsr25 803 39 such such JJ cord-024189-t7mbsr25 803 40 areas area NNS cord-024189-t7mbsr25 803 41 . . . cord-024189-t7mbsr25 804 1 Purpuric purpuric JJ cord-024189-t7mbsr25 804 2 lesions lesion NNS cord-024189-t7mbsr25 804 3 are be VBP cord-024189-t7mbsr25 804 4 not not RB cord-024189-t7mbsr25 804 5 always always RB cord-024189-t7mbsr25 804 6 palpable palpable JJ cord-024189-t7mbsr25 804 7 to to IN cord-024189-t7mbsr25 804 8 the the DT cord-024189-t7mbsr25 804 9 touch touch NN cord-024189-t7mbsr25 804 10 . . . cord-024189-t7mbsr25 805 1 The the DT cord-024189-t7mbsr25 805 2 term term NN cord-024189-t7mbsr25 805 3 palpable palpable JJ cord-024189-t7mbsr25 805 4 purpura purpura NN cord-024189-t7mbsr25 805 5 is be VBZ cord-024189-t7mbsr25 805 6 essentially essentially RB cord-024189-t7mbsr25 805 7 synonymous synonymous JJ cord-024189-t7mbsr25 805 8 with with IN cord-024189-t7mbsr25 805 9 small small JJ cord-024189-t7mbsr25 805 10 vessel vessel NN cord-024189-t7mbsr25 805 11 vasculitis vasculitis NN cord-024189-t7mbsr25 805 12 , , , cord-024189-t7mbsr25 805 13 but but CC cord-024189-t7mbsr25 805 14 does do VBZ cord-024189-t7mbsr25 805 15 not not RB cord-024189-t7mbsr25 805 16 necessarily necessarily RB cord-024189-t7mbsr25 805 17 imply imply VB cord-024189-t7mbsr25 805 18 an an DT cord-024189-t7mbsr25 805 19 immune immune JJ cord-024189-t7mbsr25 805 20 complex complex NN cord-024189-t7mbsr25 805 21 - - HYPH cord-024189-t7mbsr25 805 22 mediated mediate VBN cord-024189-t7mbsr25 805 23 pathophysiology pathophysiology NN cord-024189-t7mbsr25 805 24 ; ; : cord-024189-t7mbsr25 805 25 pauciimmune pauciimmune NN cord-024189-t7mbsr25 805 26 forms form NNS cord-024189-t7mbsr25 805 27 of of IN cord-024189-t7mbsr25 805 28 vasculitis vasculitis NN cord-024189-t7mbsr25 805 29 , , , cord-024189-t7mbsr25 805 30 such such JJ cord-024189-t7mbsr25 805 31 as as IN cord-024189-t7mbsr25 805 32 Wegener Wegener NNP cord-024189-t7mbsr25 805 33 's 's POS cord-024189-t7mbsr25 805 34 granulomatosis granulomatosis NN cord-024189-t7mbsr25 805 35 , , , cord-024189-t7mbsr25 805 36 microscopic microscopic JJ cord-024189-t7mbsr25 805 37 polyangiitis polyangiitis NN cord-024189-t7mbsr25 805 38 , , , cord-024189-t7mbsr25 805 39 and and CC cord-024189-t7mbsr25 805 40 the the DT cord-024189-t7mbsr25 805 41 Churg Churg NNP cord-024189-t7mbsr25 805 42 - - HYPH cord-024189-t7mbsr25 805 43 Strauss Strauss NNP cord-024189-t7mbsr25 805 44 syndrome syndrome NN cord-024189-t7mbsr25 805 45 , , , cord-024189-t7mbsr25 805 46 for for IN cord-024189-t7mbsr25 805 47 example example NN cord-024189-t7mbsr25 805 48 , , , cord-024189-t7mbsr25 805 49 may may MD cord-024189-t7mbsr25 805 50 present present VB cord-024189-t7mbsr25 805 51 with with IN cord-024189-t7mbsr25 805 52 identical identical JJ cord-024189-t7mbsr25 805 53 skin skin NN cord-024189-t7mbsr25 805 54 fi fi NN cord-024189-t7mbsr25 805 55 ndings nding NNS cord-024189-t7mbsr25 805 56 ( ( -LRB- cord-024189-t7mbsr25 805 57 see see VB cord-024189-t7mbsr25 805 58 Chapter Chapter NNP cord-024189-t7mbsr25 805 59 21C 21C NNP cord-024189-t7mbsr25 805 60 ) ) -RRB- cord-024189-t7mbsr25 805 61 . . . cord-024189-t7mbsr25 806 1 Biopsy Biopsy NNP cord-024189-t7mbsr25 806 2 is be VBZ cord-024189-t7mbsr25 806 3 the the DT cord-024189-t7mbsr25 806 4 diagnostic diagnostic JJ cord-024189-t7mbsr25 806 5 method method NN cord-024189-t7mbsr25 806 6 of of IN cord-024189-t7mbsr25 806 7 choice choice NN cord-024189-t7mbsr25 806 8 . . . cord-024189-t7mbsr25 807 1 Cutaneous cutaneous JJ cord-024189-t7mbsr25 807 2 biopsies biopsy NNS cord-024189-t7mbsr25 807 3 are be VBP cord-024189-t7mbsr25 807 4 associated associate VBN cord-024189-t7mbsr25 807 5 with with IN cord-024189-t7mbsr25 807 6 low low JJ cord-024189-t7mbsr25 807 7 morbidity morbidity NN cord-024189-t7mbsr25 807 8 , , , cord-024189-t7mbsr25 807 9 and and CC cord-024189-t7mbsr25 807 10 are be VBP cord-024189-t7mbsr25 807 11 generally generally RB cord-024189-t7mbsr25 807 12 suffi suffi NNP cord-024189-t7mbsr25 807 13 cient cient NNP cord-024189-t7mbsr25 807 14 to to IN cord-024189-t7mbsr25 807 15 confi confi NNP cord-024189-t7mbsr25 807 16 rm rm NNP cord-024189-t7mbsr25 807 17 one one NN cord-024189-t7mbsr25 807 18 's 's POS cord-024189-t7mbsr25 807 19 clinical clinical JJ cord-024189-t7mbsr25 807 20 suspicion suspicion NN cord-024189-t7mbsr25 807 21 . . . cord-024189-t7mbsr25 808 1 Light light JJ cord-024189-t7mbsr25 808 2 microscopy microscopy NN cord-024189-t7mbsr25 808 3 examination examination NN cord-024189-t7mbsr25 808 4 of of IN cord-024189-t7mbsr25 808 5 a a DT cord-024189-t7mbsr25 808 6 hematoxylin hematoxylin NN cord-024189-t7mbsr25 808 7 and and CC cord-024189-t7mbsr25 808 8 eosin eosin NNP cord-024189-t7mbsr25 808 9 ( ( -LRB- cord-024189-t7mbsr25 808 10 H&E H&E NNP cord-024189-t7mbsr25 808 11 ) ) -RRB- cord-024189-t7mbsr25 808 12 preparation preparation NN cord-024189-t7mbsr25 808 13 will will MD cord-024189-t7mbsr25 808 14 demonstrate demonstrate VB cord-024189-t7mbsr25 808 15 an an DT cord-024189-t7mbsr25 808 16 infl infl NNP cord-024189-t7mbsr25 808 17 ammatory ammatory NNP cord-024189-t7mbsr25 808 18 infi infi NNP cord-024189-t7mbsr25 808 19 ltrate ltrate NNP cord-024189-t7mbsr25 808 20 primarily primarily RB cord-024189-t7mbsr25 808 21 composed compose VBN cord-024189-t7mbsr25 808 22 of of IN cord-024189-t7mbsr25 808 23 mononuclear mononuclear JJ cord-024189-t7mbsr25 808 24 or or CC cord-024189-t7mbsr25 808 25 polymorphonuclear polymorphonuclear JJ cord-024189-t7mbsr25 808 26 cells cell NNS cord-024189-t7mbsr25 808 27 , , , cord-024189-t7mbsr25 808 28 as as RB cord-024189-t7mbsr25 808 29 well well RB cord-024189-t7mbsr25 808 30 as as IN cord-024189-t7mbsr25 808 31 telltale telltale JJ cord-024189-t7mbsr25 808 32 signs sign NNS cord-024189-t7mbsr25 808 33 of of IN cord-024189-t7mbsr25 808 34 small small JJ cord-024189-t7mbsr25 808 35 vessel vessel NN cord-024189-t7mbsr25 808 36 vasculitis vasculitis NN cord-024189-t7mbsr25 808 37 : : : cord-024189-t7mbsr25 808 38 leukocyte leukocyte NNP cord-024189-t7mbsr25 808 39 diapedesis diapedesis NNP cord-024189-t7mbsr25 808 40 , , , cord-024189-t7mbsr25 808 41 karyorrhexis karyorrhexis NNP cord-024189-t7mbsr25 808 42 , , , cord-024189-t7mbsr25 808 43 and and CC cord-024189-t7mbsr25 808 44 leukocytoclasis leukocytoclasis NNP cord-024189-t7mbsr25 808 45 . . . cord-024189-t7mbsr25 809 1 Although although IN cord-024189-t7mbsr25 809 2 H&E H&E NNP cord-024189-t7mbsr25 809 3 preparations preparation NNS cord-024189-t7mbsr25 809 4 are be VBP cord-024189-t7mbsr25 809 5 adequate adequate JJ cord-024189-t7mbsr25 809 6 for for IN cord-024189-t7mbsr25 809 7 confi confi NNP cord-024189-t7mbsr25 809 8 rming rme VBG cord-024189-t7mbsr25 809 9 the the DT cord-024189-t7mbsr25 809 10 presence presence NN cord-024189-t7mbsr25 809 11 of of IN cord-024189-t7mbsr25 809 12 vasculitis vasculitis NN cord-024189-t7mbsr25 809 13 , , , cord-024189-t7mbsr25 809 14 they -PRON- PRP cord-024189-t7mbsr25 809 15 often often RB cord-024189-t7mbsr25 809 16 provide provide VBP cord-024189-t7mbsr25 809 17 insuffi insuffi NNP cord-024189-t7mbsr25 809 18 cient cient NNP cord-024189-t7mbsr25 809 19 data datum NNS cord-024189-t7mbsr25 809 20 for for IN cord-024189-t7mbsr25 809 21 a a DT cord-024189-t7mbsr25 809 22 precise precise JJ cord-024189-t7mbsr25 809 23 diagnosis diagnosis NN cord-024189-t7mbsr25 809 24 . . . cord-024189-t7mbsr25 810 1 In in IN cord-024189-t7mbsr25 810 2 cases case NNS cord-024189-t7mbsr25 810 3 of of IN cord-024189-t7mbsr25 810 4 immune immune JJ cord-024189-t7mbsr25 810 5 complex complex NN cord-024189-t7mbsr25 810 6 - - HYPH cord-024189-t7mbsr25 810 7 mediated mediate VBN cord-024189-t7mbsr25 810 8 vasculitis vasculitis NN cord-024189-t7mbsr25 810 9 , , , cord-024189-t7mbsr25 810 10 direct direct JJ cord-024189-t7mbsr25 810 11 immunofl immunofl NN cord-024189-t7mbsr25 810 12 uorescence uorescence NN cord-024189-t7mbsr25 810 13 ( ( -LRB- cord-024189-t7mbsr25 810 14 DIF DIF NNP cord-024189-t7mbsr25 810 15 ) ) -RRB- cord-024189-t7mbsr25 810 16 studies study NNS cord-024189-t7mbsr25 810 17 on on IN cord-024189-t7mbsr25 810 18 the the DT cord-024189-t7mbsr25 810 19 biopsy biopsy NN cord-024189-t7mbsr25 810 20 demonstrate demonstrate VBP cord-024189-t7mbsr25 810 21 the the DT cord-024189-t7mbsr25 810 22 types type NNS cord-024189-t7mbsr25 810 23 of of IN cord-024189-t7mbsr25 810 24 immunoreactants immunoreactant NNS cord-024189-t7mbsr25 810 25 ( ( -LRB- cord-024189-t7mbsr25 810 26 i.e. i.e. FW cord-024189-t7mbsr25 810 27 , , , cord-024189-t7mbsr25 810 28 immunoglobulin immunoglobulin NN cord-024189-t7mbsr25 810 29 and and CC cord-024189-t7mbsr25 810 30 complement complement NN cord-024189-t7mbsr25 810 31 proteins protein NNS cord-024189-t7mbsr25 810 32 ) ) -RRB- cord-024189-t7mbsr25 810 33 present present JJ cord-024189-t7mbsr25 810 34 at at IN cord-024189-t7mbsr25 810 35 the the DT cord-024189-t7mbsr25 810 36 site site NN cord-024189-t7mbsr25 810 37 of of IN cord-024189-t7mbsr25 810 38 disease disease NN cord-024189-t7mbsr25 810 39 . . . cord-024189-t7mbsr25 811 1 Although although IN cord-024189-t7mbsr25 811 2 direct direct JJ cord-024189-t7mbsr25 811 3 immunofl immunofl NN cord-024189-t7mbsr25 811 4 uorescence uorescence NN cord-024189-t7mbsr25 811 5 requires require VBZ cord-024189-t7mbsr25 811 6 a a DT cord-024189-t7mbsr25 811 7 biopsy biopsy NN cord-024189-t7mbsr25 811 8 of of IN cord-024189-t7mbsr25 811 9 a a DT cord-024189-t7mbsr25 811 10 second second JJ cord-024189-t7mbsr25 811 11 cutaneous cutaneous JJ cord-024189-t7mbsr25 811 12 site site NN cord-024189-t7mbsr25 811 13 , , , cord-024189-t7mbsr25 811 14 this this DT cord-024189-t7mbsr25 811 15 procedure procedure NN cord-024189-t7mbsr25 811 16 is be VBZ cord-024189-t7mbsr25 811 17 critical critical JJ cord-024189-t7mbsr25 811 18 in in IN cord-024189-t7mbsr25 811 19 many many JJ cord-024189-t7mbsr25 811 20 cases case NNS cord-024189-t7mbsr25 811 21 to to IN cord-024189-t7mbsr25 811 22 differentiating differentiate VBG cord-024189-t7mbsr25 811 23 the the DT cord-024189-t7mbsr25 811 24 array array NN cord-024189-t7mbsr25 811 25 of of IN cord-024189-t7mbsr25 811 26 conditions condition NNS cord-024189-t7mbsr25 811 27 associated associate VBN cord-024189-t7mbsr25 811 28 with with IN cord-024189-t7mbsr25 811 29 cutaneous cutaneous JJ cord-024189-t7mbsr25 811 30 vasculitis vasculitis NN cord-024189-t7mbsr25 811 31 . . . cord-024189-t7mbsr25 812 1 Biopsy biopsy NN cord-024189-t7mbsr25 812 2 is be VBZ cord-024189-t7mbsr25 812 3 especially especially RB cord-024189-t7mbsr25 812 4 useful useful JJ cord-024189-t7mbsr25 812 5 to to TO cord-024189-t7mbsr25 812 6 exclude exclude VB cord-024189-t7mbsr25 812 7 other other JJ cord-024189-t7mbsr25 812 8 causes cause NNS cord-024189-t7mbsr25 812 9 of of IN cord-024189-t7mbsr25 812 10 vascular vascular JJ cord-024189-t7mbsr25 812 11 injury injury NN cord-024189-t7mbsr25 812 12 , , , cord-024189-t7mbsr25 812 13 including include VBG cord-024189-t7mbsr25 812 14 embolism embolism NN cord-024189-t7mbsr25 812 15 and and CC cord-024189-t7mbsr25 812 16 hypercoagulability hypercoagulability NN cord-024189-t7mbsr25 812 17 states state NNS cord-024189-t7mbsr25 812 18 , , , cord-024189-t7mbsr25 812 19 which which WDT cord-024189-t7mbsr25 812 20 may may MD cord-024189-t7mbsr25 812 21 demonstrate demonstrate VB cord-024189-t7mbsr25 812 22 evidence evidence NN cord-024189-t7mbsr25 812 23 of of IN cord-024189-t7mbsr25 812 24 erythrocyte erythrocyte NN cord-024189-t7mbsr25 812 25 extravasation extravasation NN cord-024189-t7mbsr25 812 26 but but CC cord-024189-t7mbsr25 812 27 not not RB cord-024189-t7mbsr25 812 28 immune immune VB cord-024189-t7mbsr25 812 29 complex complex JJ cord-024189-t7mbsr25 812 30 deposition deposition NN cord-024189-t7mbsr25 812 31 . . . cord-024189-t7mbsr25 813 1 Of of RB cord-024189-t7mbsr25 813 2 course course RB cord-024189-t7mbsr25 813 3 , , , cord-024189-t7mbsr25 813 4 the the DT cord-024189-t7mbsr25 813 5 presence presence NN cord-024189-t7mbsr25 813 6 of of IN cord-024189-t7mbsr25 813 7 small small JJ cord-024189-t7mbsr25 813 8 vessel vessel NN cord-024189-t7mbsr25 813 9 vasculitis vasculitis NN cord-024189-t7mbsr25 813 10 does do VBZ cord-024189-t7mbsr25 813 11 not not RB cord-024189-t7mbsr25 813 12 always always RB cord-024189-t7mbsr25 813 13 confi confi NNP cord-024189-t7mbsr25 813 14 rm rm NNP cord-024189-t7mbsr25 814 1 the the DT cord-024189-t7mbsr25 814 2 presence presence NN cord-024189-t7mbsr25 814 3 of of IN cord-024189-t7mbsr25 814 4 a a DT cord-024189-t7mbsr25 814 5 primary primary JJ cord-024189-t7mbsr25 814 6 autoimmune autoimmune JJ cord-024189-t7mbsr25 814 7 disease disease NN cord-024189-t7mbsr25 814 8 ; ; : cord-024189-t7mbsr25 814 9 malignancy malignancy NN cord-024189-t7mbsr25 814 10 , , , cord-024189-t7mbsr25 814 11 for for IN cord-024189-t7mbsr25 814 12 example example NN cord-024189-t7mbsr25 814 13 , , , cord-024189-t7mbsr25 814 14 can can MD cord-024189-t7mbsr25 814 15 also also RB cord-024189-t7mbsr25 814 16 be be VB cord-024189-t7mbsr25 814 17 associated associate VBN cord-024189-t7mbsr25 814 18 with with IN cord-024189-t7mbsr25 814 19 leukocytoclastic leukocytoclastic JJ cord-024189-t7mbsr25 814 20 vasculitis vasculitis NN cord-024189-t7mbsr25 814 21 . . . cord-024189-t7mbsr25 815 1 All all DT cord-024189-t7mbsr25 815 2 biopsies biopsy NNS cord-024189-t7mbsr25 815 3 , , , cord-024189-t7mbsr25 815 4 therefore therefore RB cord-024189-t7mbsr25 815 5 , , , cord-024189-t7mbsr25 815 6 must must MD cord-024189-t7mbsr25 815 7 be be VB cord-024189-t7mbsr25 815 8 evaluated evaluate VBN cord-024189-t7mbsr25 815 9 in in IN cord-024189-t7mbsr25 815 10 the the DT cord-024189-t7mbsr25 815 11 appropriate appropriate JJ cord-024189-t7mbsr25 815 12 clinical clinical JJ cord-024189-t7mbsr25 815 13 context context NN cord-024189-t7mbsr25 815 14 . . . cord-024189-t7mbsr25 816 1 Removal removal NN cord-024189-t7mbsr25 816 2 of of IN cord-024189-t7mbsr25 816 3 the the DT cord-024189-t7mbsr25 816 4 inciting incite VBG cord-024189-t7mbsr25 816 5 agent agent NN cord-024189-t7mbsr25 816 6 is be VBZ cord-024189-t7mbsr25 816 7 the the DT cord-024189-t7mbsr25 816 8 only only JJ cord-024189-t7mbsr25 816 9 reliable reliable JJ cord-024189-t7mbsr25 816 10 therapy therapy NN cord-024189-t7mbsr25 816 11 . . . cord-024189-t7mbsr25 817 1 In in IN cord-024189-t7mbsr25 817 2 patients patient NNS cord-024189-t7mbsr25 817 3 who who WP cord-024189-t7mbsr25 817 4 have have VBP cord-024189-t7mbsr25 817 5 been be VBN cord-024189-t7mbsr25 817 6 exposed expose VBN cord-024189-t7mbsr25 817 7 to to IN cord-024189-t7mbsr25 817 8 multiple multiple JJ cord-024189-t7mbsr25 817 9 medications medication NNS cord-024189-t7mbsr25 817 10 , , , cord-024189-t7mbsr25 817 11 determining determine VBG cord-024189-t7mbsr25 817 12 the the DT cord-024189-t7mbsr25 817 13 inciting incite VBG cord-024189-t7mbsr25 817 14 agent agent NN cord-024189-t7mbsr25 817 15 may may MD cord-024189-t7mbsr25 817 16 be be VB cord-024189-t7mbsr25 817 17 diffi diffi NNP cord-024189-t7mbsr25 817 18 cult cult NN cord-024189-t7mbsr25 817 19 , , , cord-024189-t7mbsr25 817 20 and and CC cord-024189-t7mbsr25 817 21 may may MD cord-024189-t7mbsr25 817 22 require require VB cord-024189-t7mbsr25 817 23 withdrawal withdrawal NN cord-024189-t7mbsr25 817 24 of of IN cord-024189-t7mbsr25 817 25 multiple multiple JJ cord-024189-t7mbsr25 817 26 agents agent NNS cord-024189-t7mbsr25 817 27 simultaneously simultaneously RB cord-024189-t7mbsr25 817 28 until until IN cord-024189-t7mbsr25 817 29 the the DT cord-024189-t7mbsr25 817 30 syndrome syndrome NN cord-024189-t7mbsr25 817 31 clears clear VBZ cord-024189-t7mbsr25 817 32 , , , cord-024189-t7mbsr25 817 33 typically typically RB cord-024189-t7mbsr25 817 34 in in IN cord-024189-t7mbsr25 817 35 1 1 CD cord-024189-t7mbsr25 817 36 to to IN cord-024189-t7mbsr25 817 37 2 2 CD cord-024189-t7mbsr25 817 38 weeks week NNS cord-024189-t7mbsr25 817 39 . . . cord-024189-t7mbsr25 818 1 Immunosuppression Immunosuppression NNP cord-024189-t7mbsr25 818 2 with with IN cord-024189-t7mbsr25 818 3 glucocorticoids glucocorticoid NNS cord-024189-t7mbsr25 818 4 should should MD cord-024189-t7mbsr25 818 5 be be VB cord-024189-t7mbsr25 818 6 reserved reserve VBN cord-024189-t7mbsr25 818 7 for for IN cord-024189-t7mbsr25 818 8 patients patient NNS cord-024189-t7mbsr25 818 9 with with IN cord-024189-t7mbsr25 818 10 particularly particularly RB cord-024189-t7mbsr25 818 11 fulminant fulminant JJ cord-024189-t7mbsr25 818 12 disease disease NN cord-024189-t7mbsr25 818 13 , , , cord-024189-t7mbsr25 818 14 and and CC cord-024189-t7mbsr25 818 15 may may MD cord-024189-t7mbsr25 818 16 be be VB cord-024189-t7mbsr25 818 17 discontinued discontinue VBN cord-024189-t7mbsr25 818 18 usually usually RB cord-024189-t7mbsr25 818 19 within within IN cord-024189-t7mbsr25 818 20 several several JJ cord-024189-t7mbsr25 818 21 weeks week NNS cord-024189-t7mbsr25 818 22 . . . cord-024189-t7mbsr25 819 1 The the DT cord-024189-t7mbsr25 819 2 prognosis prognosis NN cord-024189-t7mbsr25 819 3 for for IN cord-024189-t7mbsr25 819 4 patients patient NNS cord-024189-t7mbsr25 819 5 with with IN cord-024189-t7mbsr25 819 6 hypersensitivity hypersensitivity NN cord-024189-t7mbsr25 819 7 vasculitis vasculitis NN cord-024189-t7mbsr25 819 8 depends depend VBZ cord-024189-t7mbsr25 819 9 on on IN cord-024189-t7mbsr25 819 10 the the DT cord-024189-t7mbsr25 819 11 nature nature NN cord-024189-t7mbsr25 819 12 of of IN cord-024189-t7mbsr25 819 13 the the DT cord-024189-t7mbsr25 819 14 inciting incite VBG cord-024189-t7mbsr25 819 15 agent agent NN cord-024189-t7mbsr25 819 16 . . . cord-024189-t7mbsr25 820 1 In in IN cord-024189-t7mbsr25 820 2 the the DT cord-024189-t7mbsr25 820 3 case case NN cord-024189-t7mbsr25 820 4 of of IN cord-024189-t7mbsr25 820 5 drug drug NN cord-024189-t7mbsr25 820 6 - - HYPH cord-024189-t7mbsr25 820 7 induced induce VBN cord-024189-t7mbsr25 820 8 vasculitis vasculitis NN cord-024189-t7mbsr25 820 9 , , , cord-024189-t7mbsr25 820 10 multiple multiple JJ cord-024189-t7mbsr25 820 11 agents agent NNS cord-024189-t7mbsr25 820 12 may may MD cord-024189-t7mbsr25 820 13 need need VB cord-024189-t7mbsr25 820 14 to to TO cord-024189-t7mbsr25 820 15 be be VB cord-024189-t7mbsr25 820 16 discontinued discontinue VBN cord-024189-t7mbsr25 820 17 and and CC cord-024189-t7mbsr25 820 18 re re VBN cord-024189-t7mbsr25 820 19 - - VBN cord-024189-t7mbsr25 820 20 introduced introduce VBN cord-024189-t7mbsr25 820 21 gradually gradually RB cord-024189-t7mbsr25 820 22 . . . cord-024189-t7mbsr25 821 1 Approximately approximately RB cord-024189-t7mbsr25 821 2 half half NN cord-024189-t7mbsr25 821 3 of of IN cord-024189-t7mbsr25 821 4 cases case NNS cord-024189-t7mbsr25 821 5 of of IN cord-024189-t7mbsr25 821 6 isolated isolate VBN cord-024189-t7mbsr25 821 7 cutaneous cutaneous JJ cord-024189-t7mbsr25 821 8 angiitis angiitis RB cord-024189-t7mbsr25 821 9 do do VBP cord-024189-t7mbsr25 821 10 not not RB cord-024189-t7mbsr25 821 11 have have VB cord-024189-t7mbsr25 821 12 an an DT cord-024189-t7mbsr25 821 13 obvious obvious JJ cord-024189-t7mbsr25 821 14 cause cause NN cord-024189-t7mbsr25 821 15 . . . cord-024189-t7mbsr25 822 1 Many many JJ cord-024189-t7mbsr25 822 2 such such JJ cord-024189-t7mbsr25 822 3 cases case NNS cord-024189-t7mbsr25 822 4 are be VBP cord-024189-t7mbsr25 822 5 associated associate VBN cord-024189-t7mbsr25 822 6 with with IN cord-024189-t7mbsr25 822 7 a a DT cord-024189-t7mbsr25 822 8 relapsing relapse VBG cord-024189-t7mbsr25 822 9 and and CC cord-024189-t7mbsr25 822 10 remitting remit VBG cord-024189-t7mbsr25 822 11 course course NN cord-024189-t7mbsr25 822 12 , , , cord-024189-t7mbsr25 822 13 but but CC cord-024189-t7mbsr25 822 14 remain remain VBP cord-024189-t7mbsr25 822 15 restricted restricted JJ cord-024189-t7mbsr25 822 16 to to IN cord-024189-t7mbsr25 822 17 the the DT cord-024189-t7mbsr25 822 18 skin skin NN cord-024189-t7mbsr25 822 19 and and CC cord-024189-t7mbsr25 822 20 do do VBP cord-024189-t7mbsr25 822 21 not not RB cord-024189-t7mbsr25 822 22 mandate mandate VB cord-024189-t7mbsr25 822 23 aggressive aggressive JJ cord-024189-t7mbsr25 822 24 immunosuppressive immunosuppressive JJ cord-024189-t7mbsr25 822 25 therapy therapy NN cord-024189-t7mbsr25 822 26 . . . cord-024189-t7mbsr25 823 1 In in IN cord-024189-t7mbsr25 823 2 1933 1933 CD cord-024189-t7mbsr25 823 3 , , , cord-024189-t7mbsr25 823 4 Wintrobe Wintrobe NNP cord-024189-t7mbsr25 823 5 and and CC cord-024189-t7mbsr25 823 6 Buell Buell NNP cord-024189-t7mbsr25 823 7 noted note VBD cord-024189-t7mbsr25 823 8 that that IN cord-024189-t7mbsr25 823 9 when when WRB cord-024189-t7mbsr25 823 10 serum serum NN cord-024189-t7mbsr25 823 11 from from IN cord-024189-t7mbsr25 823 12 a a DT cord-024189-t7mbsr25 823 13 patient patient NN cord-024189-t7mbsr25 823 14 with with IN cord-024189-t7mbsr25 823 15 a a DT cord-024189-t7mbsr25 823 16 hyperviscosity hyperviscosity NN cord-024189-t7mbsr25 823 17 syndrome syndrome NN cord-024189-t7mbsr25 823 18 due due IN cord-024189-t7mbsr25 823 19 to to IN cord-024189-t7mbsr25 823 20 multiple multiple JJ cord-024189-t7mbsr25 823 21 myeloma myeloma NN cord-024189-t7mbsr25 823 22 was be VBD cord-024189-t7mbsr25 823 23 held hold VBN cord-024189-t7mbsr25 823 24 at at IN cord-024189-t7mbsr25 823 25 temperatures temperature NNS cord-024189-t7mbsr25 823 26 less less JJR cord-024189-t7mbsr25 823 27 than than IN cord-024189-t7mbsr25 823 28 37 37 CD cord-024189-t7mbsr25 823 29 ° ° NN cord-024189-t7mbsr25 823 30 C c NN cord-024189-t7mbsr25 823 31 , , , cord-024189-t7mbsr25 823 32 a a DT cord-024189-t7mbsr25 823 33 protein protein NN cord-024189-t7mbsr25 823 34 precipitate precipitate NN cord-024189-t7mbsr25 823 35 formed form VBN cord-024189-t7mbsr25 823 36 ( ( -LRB- cord-024189-t7mbsr25 823 37 4 4 CD cord-024189-t7mbsr25 823 38 ) ) -RRB- cord-024189-t7mbsr25 823 39 . . . cord-024189-t7mbsr25 824 1 In in IN cord-024189-t7mbsr25 824 2 1947 1947 CD cord-024189-t7mbsr25 824 3 , , , cord-024189-t7mbsr25 824 4 this this DT cord-024189-t7mbsr25 824 5 " " `` cord-024189-t7mbsr25 824 6 cold cold JJ cord-024189-t7mbsr25 824 7 precipitable precipitable JJ cord-024189-t7mbsr25 824 8 serum serum NN cord-024189-t7mbsr25 824 9 globulin globulin NN cord-024189-t7mbsr25 824 10 " " '' cord-024189-t7mbsr25 824 11 was be VBD cord-024189-t7mbsr25 824 12 referred refer VBN cord-024189-t7mbsr25 824 13 to to IN cord-024189-t7mbsr25 824 14 for for IN cord-024189-t7mbsr25 824 15 the the DT cord-024189-t7mbsr25 824 16 fi fi NNP cord-024189-t7mbsr25 824 17 rst rst NNP cord-024189-t7mbsr25 824 18 time time NN cord-024189-t7mbsr25 824 19 as as IN cord-024189-t7mbsr25 824 20 a a DT cord-024189-t7mbsr25 824 21 " " `` cord-024189-t7mbsr25 824 22 cryoglobulin cryoglobulin NN cord-024189-t7mbsr25 824 23 . . . cord-024189-t7mbsr25 824 24 " " '' cord-024189-t7mbsr25 825 1 Cryoglobulins cryoglobulin NNS cord-024189-t7mbsr25 825 2 are be VBP cord-024189-t7mbsr25 825 3 immune immune JJ cord-024189-t7mbsr25 825 4 complexes complex NNS cord-024189-t7mbsr25 825 5 that that WDT cord-024189-t7mbsr25 825 6 are be VBP cord-024189-t7mbsr25 825 7 characterized characterize VBN cord-024189-t7mbsr25 825 8 by by IN cord-024189-t7mbsr25 825 9 their -PRON- PRP$ cord-024189-t7mbsr25 825 10 tendency tendency NN cord-024189-t7mbsr25 825 11 to to TO cord-024189-t7mbsr25 825 12 precipitate precipitate VB cord-024189-t7mbsr25 825 13 from from IN cord-024189-t7mbsr25 825 14 serum serum NN cord-024189-t7mbsr25 825 15 under under IN cord-024189-t7mbsr25 825 16 conditions condition NNS cord-024189-t7mbsr25 825 17 of of IN cord-024189-t7mbsr25 825 18 cold cold NN cord-024189-t7mbsr25 825 19 . . . cord-024189-t7mbsr25 826 1 Cryoglobulins cryoglobulin NNS cord-024189-t7mbsr25 826 2 , , , cord-024189-t7mbsr25 826 3 detectable detectable JJ cord-024189-t7mbsr25 826 4 to to IN cord-024189-t7mbsr25 826 5 a a DT cord-024189-t7mbsr25 826 6 varying vary VBG cord-024189-t7mbsr25 826 7 degree degree NN cord-024189-t7mbsr25 826 8 in in IN cord-024189-t7mbsr25 826 9 a a DT cord-024189-t7mbsr25 826 10 wide wide JJ cord-024189-t7mbsr25 826 11 array array NN cord-024189-t7mbsr25 826 12 of of IN cord-024189-t7mbsr25 826 13 infl infl NNP cord-024189-t7mbsr25 826 14 ammatory ammatory NNP cord-024189-t7mbsr25 826 15 conditions condition NNS cord-024189-t7mbsr25 826 16 , , , cord-024189-t7mbsr25 826 17 are be VBP cord-024189-t7mbsr25 826 18 not not RB cord-024189-t7mbsr25 826 19 invariably invariably RB cord-024189-t7mbsr25 826 20 pathogenic pathogenic JJ cord-024189-t7mbsr25 826 21 . . . cord-024189-t7mbsr25 827 1 In in IN cord-024189-t7mbsr25 827 2 some some DT cord-024189-t7mbsr25 827 3 patients patient NNS cord-024189-t7mbsr25 827 4 , , , cord-024189-t7mbsr25 827 5 however however RB cord-024189-t7mbsr25 827 6 , , , cord-024189-t7mbsr25 827 7 cryoglobulins cryoglobulins NNP cord-024189-t7mbsr25 827 8 deposit deposit VBP cord-024189-t7mbsr25 827 9 in in IN cord-024189-t7mbsr25 827 10 the the DT cord-024189-t7mbsr25 827 11 small small JJ cord-024189-t7mbsr25 827 12 - - HYPH cord-024189-t7mbsr25 827 13 and and CC cord-024189-t7mbsr25 827 14 medium medium NN cord-024189-t7mbsr25 827 15 - - HYPH cord-024189-t7mbsr25 827 16 sized sized JJ cord-024189-t7mbsr25 827 17 blood blood NN cord-024189-t7mbsr25 827 18 vessels vessel NNS cord-024189-t7mbsr25 827 19 and and CC cord-024189-t7mbsr25 827 20 activate activate VB cord-024189-t7mbsr25 827 21 complement complement NN cord-024189-t7mbsr25 827 22 , , , cord-024189-t7mbsr25 827 23 leading lead VBG cord-024189-t7mbsr25 827 24 to to IN cord-024189-t7mbsr25 827 25 cryoglobulinemic cryoglobulinemic JJ cord-024189-t7mbsr25 827 26 vasculitis vasculitis NN cord-024189-t7mbsr25 827 27 ( ( -LRB- cord-024189-t7mbsr25 827 28 5 5 CD cord-024189-t7mbsr25 827 29 ) ) -RRB- cord-024189-t7mbsr25 827 30 . . . cord-024189-t7mbsr25 828 1 Three three CD cord-024189-t7mbsr25 828 2 major major JJ cord-024189-t7mbsr25 828 3 types type NNS cord-024189-t7mbsr25 828 4 of of IN cord-024189-t7mbsr25 828 5 cryoglobulinemia cryoglobulinemia NN cord-024189-t7mbsr25 828 6 are be VBP cord-024189-t7mbsr25 828 7 recognized recognize VBN cord-024189-t7mbsr25 828 8 , , , cord-024189-t7mbsr25 828 9 defi defi NNP cord-024189-t7mbsr25 828 10 ned ned NNP cord-024189-t7mbsr25 828 11 by by IN cord-024189-t7mbsr25 828 12 the the DT cord-024189-t7mbsr25 828 13 specifi specifi NN cord-024189-t7mbsr25 828 14 c c NN cord-024189-t7mbsr25 828 15 kinds kind NNS cord-024189-t7mbsr25 828 16 of of IN cord-024189-t7mbsr25 828 17 immunoglobulins immunoglobulin NNS cord-024189-t7mbsr25 828 18 with with IN cord-024189-t7mbsr25 828 19 which which WDT cord-024189-t7mbsr25 828 20 they -PRON- PRP cord-024189-t7mbsr25 828 21 are be VBP cord-024189-t7mbsr25 828 22 associated associate VBN cord-024189-t7mbsr25 828 23 . . . cord-024189-t7mbsr25 829 1 Type type NN cord-024189-t7mbsr25 829 2 I -PRON- PRP cord-024189-t7mbsr25 829 3 cryoglobulinemia cryoglobulinemia NN cord-024189-t7mbsr25 829 4 , , , cord-024189-t7mbsr25 829 5 characterized characterize VBN cord-024189-t7mbsr25 829 6 by by IN cord-024189-t7mbsr25 829 7 a a DT cord-024189-t7mbsr25 829 8 monoclonal monoclonal JJ cord-024189-t7mbsr25 829 9 gammopathy gammopathy NN cord-024189-t7mbsr25 829 10 ( ( -LRB- cord-024189-t7mbsr25 829 11 generally generally RB cord-024189-t7mbsr25 829 12 IgG IgG NNP cord-024189-t7mbsr25 829 13 or or CC cord-024189-t7mbsr25 829 14 IgM IgM NNP cord-024189-t7mbsr25 829 15 ) ) -RRB- cord-024189-t7mbsr25 829 16 , , , cord-024189-t7mbsr25 829 17 can can MD cord-024189-t7mbsr25 829 18 be be VB cord-024189-t7mbsr25 829 19 associated associate VBN cord-024189-t7mbsr25 829 20 with with IN cord-024189-t7mbsr25 829 21 Waldenström Waldenström NNP cord-024189-t7mbsr25 829 22 's 's POS cord-024189-t7mbsr25 829 23 macroglobulinemia macroglobulinemia NN cord-024189-t7mbsr25 829 24 or or CC cord-024189-t7mbsr25 829 25 , , , cord-024189-t7mbsr25 829 26 less less RBR cord-024189-t7mbsr25 829 27 frequently frequently RB cord-024189-t7mbsr25 829 28 , , , cord-024189-t7mbsr25 829 29 multiple multiple JJ cord-024189-t7mbsr25 829 30 myeloma myeloma NN cord-024189-t7mbsr25 829 31 . . . cord-024189-t7mbsr25 830 1 Type Type NNP cord-024189-t7mbsr25 830 2 I I NNP cord-024189-t7mbsr25 830 3 IgA IgA NNP cord-024189-t7mbsr25 830 4 cryoglobulinemia cryoglobulinemia NNP cord-024189-t7mbsr25 830 5 has have VBZ cord-024189-t7mbsr25 830 6 also also RB cord-024189-t7mbsr25 830 7 been be VBN cord-024189-t7mbsr25 830 8 described describe VBN cord-024189-t7mbsr25 830 9 , , , cord-024189-t7mbsr25 830 10 although although IN cord-024189-t7mbsr25 830 11 this this DT cord-024189-t7mbsr25 830 12 is be VBZ cord-024189-t7mbsr25 830 13 quite quite RB cord-024189-t7mbsr25 830 14 rare rare JJ cord-024189-t7mbsr25 830 15 . . . cord-024189-t7mbsr25 831 1 In in IN cord-024189-t7mbsr25 831 2 contrast contrast NN cord-024189-t7mbsr25 831 3 to to IN cord-024189-t7mbsr25 831 4 the the DT cord-024189-t7mbsr25 831 5 monoclonal monoclonal JJ cord-024189-t7mbsr25 831 6 nature nature NN cord-024189-t7mbsr25 831 7 of of IN cord-024189-t7mbsr25 831 8 type type NN cord-024189-t7mbsr25 831 9 I -PRON- PRP cord-024189-t7mbsr25 831 10 cryoglobulinemia cryoglobulinemia NN cord-024189-t7mbsr25 831 11 , , , cord-024189-t7mbsr25 831 12 type type NN cord-024189-t7mbsr25 831 13 II ii NN cord-024189-t7mbsr25 831 14 and and CC cord-024189-t7mbsr25 831 15 type type NN cord-024189-t7mbsr25 831 16 III iii CD cord-024189-t7mbsr25 831 17 cryoglobulinemias cryoglobulinemias NNP cord-024189-t7mbsr25 831 18 are be VBP cord-024189-t7mbsr25 831 19 known know VBN cord-024189-t7mbsr25 831 20 as as IN cord-024189-t7mbsr25 831 21 " " `` cord-024189-t7mbsr25 831 22 mixed mixed JJ cord-024189-t7mbsr25 831 23 " " '' cord-024189-t7mbsr25 831 24 cryoglobulinemias cryoglobulinemias NNP cord-024189-t7mbsr25 831 25 because because IN cord-024189-t7mbsr25 831 26 they -PRON- PRP cord-024189-t7mbsr25 831 27 are be VBP cord-024189-t7mbsr25 831 28 comprised comprise VBN cord-024189-t7mbsr25 831 29 of of IN cord-024189-t7mbsr25 831 30 both both DT cord-024189-t7mbsr25 831 31 IgG igg NN cord-024189-t7mbsr25 831 32 and and CC cord-024189-t7mbsr25 832 1 IgM. IgM. NNP cord-024189-t7mbsr25 833 1 In in IN cord-024189-t7mbsr25 833 2 most most JJS cord-024189-t7mbsr25 833 3 cases case NNS cord-024189-t7mbsr25 833 4 of of IN cord-024189-t7mbsr25 833 5 type type NN cord-024189-t7mbsr25 833 6 II II NNP cord-024189-t7mbsr25 833 7 cryoglobulinemia cryoglobulinemia NN cord-024189-t7mbsr25 833 8 , , , cord-024189-t7mbsr25 833 9 more more JJR cord-024189-t7mbsr25 833 10 than than IN cord-024189-t7mbsr25 833 11 90 90 CD cord-024189-t7mbsr25 833 12 % % NN cord-024189-t7mbsr25 833 13 of of IN cord-024189-t7mbsr25 833 14 which which WDT cord-024189-t7mbsr25 833 15 are be VBP cord-024189-t7mbsr25 833 16 caused cause VBN cord-024189-t7mbsr25 833 17 by by IN cord-024189-t7mbsr25 833 18 hepatitis hepatitis NN cord-024189-t7mbsr25 833 19 C C NNP cord-024189-t7mbsr25 833 20 infections infection NNS cord-024189-t7mbsr25 833 21 , , , cord-024189-t7mbsr25 833 22 the the DT cord-024189-t7mbsr25 833 23 cryoproteins cryoprotein NNS cord-024189-t7mbsr25 833 24 consist consist VBP cord-024189-t7mbsr25 833 25 of of IN cord-024189-t7mbsr25 833 26 monoclonal monoclonal JJ cord-024189-t7mbsr25 833 27 IgM IgM NNP cord-024189-t7mbsr25 833 28 and and CC cord-024189-t7mbsr25 833 29 polyclonal polyclonal JJ cord-024189-t7mbsr25 833 30 IgG. IgG. NNP cord-024189-t7mbsr25 833 31 Cases case NNS cord-024189-t7mbsr25 833 32 of of IN cord-024189-t7mbsr25 833 33 type type NN cord-024189-t7mbsr25 833 34 II II NNP cord-024189-t7mbsr25 833 35 cryoglobulinemia cryoglobulinemia NN cord-024189-t7mbsr25 833 36 not not RB cord-024189-t7mbsr25 833 37 associated associate VBN cord-024189-t7mbsr25 833 38 with with IN cord-024189-t7mbsr25 833 39 hepatitis hepatitis NN cord-024189-t7mbsr25 833 40 C C NNP cord-024189-t7mbsr25 833 41 infections infection NNS cord-024189-t7mbsr25 833 42 are be VBP cord-024189-t7mbsr25 833 43 sometimes sometimes RB cord-024189-t7mbsr25 833 44 termed term VBN cord-024189-t7mbsr25 833 45 " " `` cord-024189-t7mbsr25 833 46 mixed mixed JJ cord-024189-t7mbsr25 833 47 essential essential JJ cord-024189-t7mbsr25 833 48 " " '' cord-024189-t7mbsr25 833 49 cryoglobulinemia cryoglobulinemia NN cord-024189-t7mbsr25 833 50 . . . cord-024189-t7mbsr25 834 1 Such such JJ cord-024189-t7mbsr25 834 2 cases case NNS cord-024189-t7mbsr25 834 3 may may MD cord-024189-t7mbsr25 834 4 be be VB cord-024189-t7mbsr25 834 5 associated associate VBN cord-024189-t7mbsr25 834 6 with with IN cord-024189-t7mbsr25 834 7 a a DT cord-024189-t7mbsr25 834 8 still still RB cord-024189-t7mbsr25 834 9 undefi undefi JJ cord-024189-t7mbsr25 834 10 ned ned NNP cord-024189-t7mbsr25 834 11 viral viral JJ cord-024189-t7mbsr25 834 12 infection infection NN cord-024189-t7mbsr25 834 13 . . . cord-024189-t7mbsr25 835 1 Type Type NNP cord-024189-t7mbsr25 835 2 III iii CD cord-024189-t7mbsr25 835 3 cryoglobulinemia cryoglobulinemia NN cord-024189-t7mbsr25 835 4 , , , cord-024189-t7mbsr25 835 5 typically typically RB cord-024189-t7mbsr25 835 6 associated associate VBN cord-024189-t7mbsr25 835 7 with with IN cord-024189-t7mbsr25 835 8 polyclonal polyclonal JJ cord-024189-t7mbsr25 835 9 IgG igg NN cord-024189-t7mbsr25 835 10 and and CC cord-024189-t7mbsr25 835 11 polyclonal polyclonal NNP cord-024189-t7mbsr25 835 12 IgM IgM NNP cord-024189-t7mbsr25 835 13 , , , cord-024189-t7mbsr25 835 14 is be VBZ cord-024189-t7mbsr25 835 15 associated associate VBN cord-024189-t7mbsr25 835 16 with with IN cord-024189-t7mbsr25 835 17 many many JJ cord-024189-t7mbsr25 835 18 forms form NNS cord-024189-t7mbsr25 835 19 of of IN cord-024189-t7mbsr25 835 20 chronic chronic JJ cord-024189-t7mbsr25 835 21 infl infl NN cord-024189-t7mbsr25 835 22 ammation ammation NN cord-024189-t7mbsr25 835 23 , , , cord-024189-t7mbsr25 835 24 including include VBG cord-024189-t7mbsr25 835 25 infection infection NN cord-024189-t7mbsr25 835 26 and and CC cord-024189-t7mbsr25 835 27 autoimmune autoimmune JJ cord-024189-t7mbsr25 835 28 disease disease NN cord-024189-t7mbsr25 835 29 . . . cord-024189-t7mbsr25 836 1 Not not RB cord-024189-t7mbsr25 836 2 every every DT cord-024189-t7mbsr25 836 3 form form NN cord-024189-t7mbsr25 836 4 of of IN cord-024189-t7mbsr25 836 5 cryoglobulinemia cryoglobulinemia NN cord-024189-t7mbsr25 836 6 fi fi NN cord-024189-t7mbsr25 836 7 ts ts NNP cord-024189-t7mbsr25 836 8 neatly neatly RB cord-024189-t7mbsr25 836 9 into into IN cord-024189-t7mbsr25 836 10 this this DT cord-024189-t7mbsr25 836 11 classifi classifi NN cord-024189-t7mbsr25 836 12 cation cation NN cord-024189-t7mbsr25 836 13 system system NN cord-024189-t7mbsr25 836 14 ; ; : cord-024189-t7mbsr25 836 15 cryoglobulins cryoglobulins NNP cord-024189-t7mbsr25 836 16 can can MD cord-024189-t7mbsr25 836 17 , , , cord-024189-t7mbsr25 836 18 for for IN cord-024189-t7mbsr25 836 19 example example NN cord-024189-t7mbsr25 836 20 , , , cord-024189-t7mbsr25 836 21 have have VBP cord-024189-t7mbsr25 836 22 an an DT cord-024189-t7mbsr25 836 23 oligoclonal oligoclonal JJ cord-024189-t7mbsr25 836 24 antibody antibody NN cord-024189-t7mbsr25 836 25 component component NN cord-024189-t7mbsr25 836 26 . . . cord-024189-t7mbsr25 837 1 Type type NN cord-024189-t7mbsr25 837 2 I -PRON- PRP cord-024189-t7mbsr25 837 3 cryoglobulinemia cryoglobulinemia NN cord-024189-t7mbsr25 837 4 rarely rarely RB cord-024189-t7mbsr25 837 5 presents present VBZ cord-024189-t7mbsr25 837 6 with with IN cord-024189-t7mbsr25 837 7 signs sign NNS cord-024189-t7mbsr25 837 8 and and CC cord-024189-t7mbsr25 837 9 symptoms symptom NNS cord-024189-t7mbsr25 837 10 of of IN cord-024189-t7mbsr25 837 11 vasculitis vasculitis NN cord-024189-t7mbsr25 837 12 . . . cord-024189-t7mbsr25 838 1 When when WRB cord-024189-t7mbsr25 838 2 symptomatic symptomatic JJ cord-024189-t7mbsr25 838 3 , , , cord-024189-t7mbsr25 838 4 type type NN cord-024189-t7mbsr25 838 5 I -PRON- PRP cord-024189-t7mbsr25 838 6 cryoglobulinemia cryoglobulinemia NN cord-024189-t7mbsr25 838 7 may may MD cord-024189-t7mbsr25 838 8 be be VB cord-024189-t7mbsr25 838 9 associated associate VBN cord-024189-t7mbsr25 838 10 with with IN cord-024189-t7mbsr25 838 11 a a DT cord-024189-t7mbsr25 838 12 hyperviscosity hyperviscosity NN cord-024189-t7mbsr25 838 13 syndrome syndrome NN cord-024189-t7mbsr25 838 14 that that WDT cord-024189-t7mbsr25 838 15 can can MD cord-024189-t7mbsr25 838 16 lead lead VB cord-024189-t7mbsr25 838 17 to to IN cord-024189-t7mbsr25 838 18 serious serious JJ cord-024189-t7mbsr25 838 19 neurologic neurologic JJ cord-024189-t7mbsr25 838 20 manifestations manifestation NNS cord-024189-t7mbsr25 838 21 , , , cord-024189-t7mbsr25 838 22 including include VBG cord-024189-t7mbsr25 838 23 dizziness dizziness NN cord-024189-t7mbsr25 838 24 , , , cord-024189-t7mbsr25 838 25 confusion confusion NN cord-024189-t7mbsr25 838 26 , , , cord-024189-t7mbsr25 838 27 headache headache NN cord-024189-t7mbsr25 838 28 , , , cord-024189-t7mbsr25 838 29 and and CC cord-024189-t7mbsr25 838 30 stroke stroke NN cord-024189-t7mbsr25 838 31 . . . cord-024189-t7mbsr25 839 1 Type type NN cord-024189-t7mbsr25 839 2 I -PRON- PRP cord-024189-t7mbsr25 839 3 cryoglobulinemia cryoglobulinemia NN cord-024189-t7mbsr25 839 4 can can MD cord-024189-t7mbsr25 839 5 also also RB cord-024189-t7mbsr25 839 6 be be VB cord-024189-t7mbsr25 839 7 associated associate VBN cord-024189-t7mbsr25 839 8 with with IN cord-024189-t7mbsr25 839 9 other other JJ cord-024189-t7mbsr25 839 10 evidence evidence NN cord-024189-t7mbsr25 839 11 of of IN cord-024189-t7mbsr25 839 12 vascular vascular JJ cord-024189-t7mbsr25 839 13 stasis stasis NN cord-024189-t7mbsr25 839 14 , , , cord-024189-t7mbsr25 839 15 including include VBG cord-024189-t7mbsr25 839 16 livedo livedo NNP cord-024189-t7mbsr25 839 17 reticularis reticularis NNPS cord-024189-t7mbsr25 839 18 , , , cord-024189-t7mbsr25 839 19 acrocyanosis acrocyanosis NNP cord-024189-t7mbsr25 839 20 , , , cord-024189-t7mbsr25 839 21 and and CC cord-024189-t7mbsr25 839 22 digital digital JJ cord-024189-t7mbsr25 839 23 gangrene gangrene NN cord-024189-t7mbsr25 839 24 ( ( -LRB- cord-024189-t7mbsr25 839 25 Figure figure NN cord-024189-t7mbsr25 839 26 _SP cord-024189-t7mbsr25 839 27 21D-2 21d-2 CD cord-024189-t7mbsr25 839 28 ) ) -RRB- cord-024189-t7mbsr25 839 29 . . . cord-024189-t7mbsr25 840 1 Type Type NNP cord-024189-t7mbsr25 840 2 II II NNP cord-024189-t7mbsr25 840 3 and and CC cord-024189-t7mbsr25 840 4 type type NN cord-024189-t7mbsr25 840 5 III iii CD cord-024189-t7mbsr25 840 6 cryoglobulinemias cryoglobulinemias NNP cord-024189-t7mbsr25 840 7 often often RB cord-024189-t7mbsr25 840 8 present present VBP cord-024189-t7mbsr25 840 9 with with IN cord-024189-t7mbsr25 840 10 a a DT cord-024189-t7mbsr25 840 11 triad triad NN cord-024189-t7mbsr25 840 12 of of IN cord-024189-t7mbsr25 840 13 signs sign NNS cord-024189-t7mbsr25 840 14 and and CC cord-024189-t7mbsr25 840 15 symptoms symptom NNS cord-024189-t7mbsr25 840 16 : : : cord-024189-t7mbsr25 840 17 purpura purpura NN cord-024189-t7mbsr25 840 18 , , , cord-024189-t7mbsr25 840 19 arthralgias arthralgias NNP cord-024189-t7mbsr25 840 20 , , , cord-024189-t7mbsr25 840 21 and and CC cord-024189-t7mbsr25 840 22 myalgias myalgias NNP cord-024189-t7mbsr25 840 23 . . . cord-024189-t7mbsr25 841 1 The the DT cord-024189-t7mbsr25 841 2 purpura purpura NN cord-024189-t7mbsr25 841 3 may may MD cord-024189-t7mbsr25 841 4 be be VB cord-024189-t7mbsr25 841 5 extensive extensive JJ cord-024189-t7mbsr25 841 6 and and CC cord-024189-t7mbsr25 841 7 confl confl NN cord-024189-t7mbsr25 841 8 uent uent NN cord-024189-t7mbsr25 841 9 , , , cord-024189-t7mbsr25 841 10 and and CC cord-024189-t7mbsr25 841 11 sometimes sometimes RB cord-024189-t7mbsr25 841 12 involves involve VBZ cord-024189-t7mbsr25 841 13 the the DT cord-024189-t7mbsr25 841 14 trunk trunk NN cord-024189-t7mbsr25 841 15 , , , cord-024189-t7mbsr25 841 16 upper upper JJ cord-024189-t7mbsr25 841 17 extremities extremity NNS cord-024189-t7mbsr25 841 18 , , , cord-024189-t7mbsr25 841 19 and and CC cord-024189-t7mbsr25 841 20 even even RB cord-024189-t7mbsr25 841 21 the the DT cord-024189-t7mbsr25 841 22 face face NN cord-024189-t7mbsr25 841 23 ( ( -LRB- cord-024189-t7mbsr25 841 24 albeit albeit IN cord-024189-t7mbsr25 841 25 in in IN cord-024189-t7mbsr25 841 26 most most JJS cord-024189-t7mbsr25 841 27 cases case NNS cord-024189-t7mbsr25 841 28 the the DT cord-024189-t7mbsr25 841 29 rash rash NN cord-024189-t7mbsr25 841 30 is be VBZ cord-024189-t7mbsr25 841 31 confi confi NNP cord-024189-t7mbsr25 841 32 ned ned NNP cord-024189-t7mbsr25 841 33 to to IN cord-024189-t7mbsr25 841 34 the the DT cord-024189-t7mbsr25 841 35 lower low JJR cord-024189-t7mbsr25 841 36 extremities extremity NNS cord-024189-t7mbsr25 841 37 ) ) -RRB- cord-024189-t7mbsr25 841 38 . . . cord-024189-t7mbsr25 842 1 Other other JJ cord-024189-t7mbsr25 842 2 common common JJ cord-024189-t7mbsr25 842 3 organ organ NN cord-024189-t7mbsr25 842 4 system system NN cord-024189-t7mbsr25 842 5 involvement involvement NN cord-024189-t7mbsr25 842 6 , , , cord-024189-t7mbsr25 842 7 more more RBR cord-024189-t7mbsr25 842 8 common common JJ cord-024189-t7mbsr25 842 9 in in IN cord-024189-t7mbsr25 842 10 type type NN cord-024189-t7mbsr25 842 11 II II NNP cord-024189-t7mbsr25 842 12 than than IN cord-024189-t7mbsr25 842 13 in in IN cord-024189-t7mbsr25 842 14 type type NN cord-024189-t7mbsr25 842 15 III iii CD cord-024189-t7mbsr25 842 16 cryoglobulinemia cryoglobulinemia NN cord-024189-t7mbsr25 842 17 , , , cord-024189-t7mbsr25 842 18 includes include VBZ cord-024189-t7mbsr25 842 19 membranoproliferative membranoproliferative NNP cord-024189-t7mbsr25 842 20 glomerulonephritis glomerulonephritis NN cord-024189-t7mbsr25 842 21 ( ( -LRB- cord-024189-t7mbsr25 842 22 Figure figure NN cord-024189-t7mbsr25 842 23 21D-3 21d-3 CD cord-024189-t7mbsr25 842 24 ) ) -RRB- cord-024189-t7mbsr25 842 25 , , , cord-024189-t7mbsr25 842 26 peripheral peripheral JJ cord-024189-t7mbsr25 842 27 neuropathy neuropathy NN cord-024189-t7mbsr25 842 28 , , , cord-024189-t7mbsr25 842 29 and and CC cord-024189-t7mbsr25 842 30 cutaneous cutaneous JJ cord-024189-t7mbsr25 842 31 ulcerations ulceration NNS cord-024189-t7mbsr25 842 32 ( ( -LRB- cord-024189-t7mbsr25 842 33 the the DT cord-024189-t7mbsr25 842 34 result result NN cord-024189-t7mbsr25 842 35 of of IN cord-024189-t7mbsr25 842 36 medium medium JJ cord-024189-t7mbsr25 842 37 vessel vessel NN cord-024189-t7mbsr25 842 38 vasculitis vasculitis NN cord-024189-t7mbsr25 842 39 , , , cord-024189-t7mbsr25 842 40 in in IN cord-024189-t7mbsr25 842 41 contrast contrast NN cord-024189-t7mbsr25 842 42 to to IN cord-024189-t7mbsr25 842 43 the the DT cord-024189-t7mbsr25 842 44 smallsized smallsize VBN cord-024189-t7mbsr25 842 45 vessel vessel NN cord-024189-t7mbsr25 842 46 involvement involvement NN cord-024189-t7mbsr25 842 47 that that WDT cord-024189-t7mbsr25 842 48 leads lead VBZ cord-024189-t7mbsr25 842 49 to to IN cord-024189-t7mbsr25 842 50 purpura purpura NN cord-024189-t7mbsr25 842 51 ) ) -RRB- cord-024189-t7mbsr25 842 52 . . . cord-024189-t7mbsr25 843 1 Biopsy biopsy NN cord-024189-t7mbsr25 843 2 of of IN cord-024189-t7mbsr25 843 3 an an DT cord-024189-t7mbsr25 843 4 affected affected JJ cord-024189-t7mbsr25 843 5 organ organ NN cord-024189-t7mbsr25 843 6 ( ( -LRB- cord-024189-t7mbsr25 843 7 such such JJ cord-024189-t7mbsr25 843 8 as as IN cord-024189-t7mbsr25 843 9 the the DT cord-024189-t7mbsr25 843 10 skin skin NN cord-024189-t7mbsr25 843 11 or or CC cord-024189-t7mbsr25 843 12 kidney kidney NN cord-024189-t7mbsr25 843 13 ) ) -RRB- cord-024189-t7mbsr25 843 14 may may MD cord-024189-t7mbsr25 843 15 be be VB cord-024189-t7mbsr25 843 16 the the DT cord-024189-t7mbsr25 843 17 most most RBS cord-024189-t7mbsr25 843 18 straightforward straightforward JJ cord-024189-t7mbsr25 843 19 method method NN cord-024189-t7mbsr25 843 20 of of IN cord-024189-t7mbsr25 843 21 confi confi NNP cord-024189-t7mbsr25 843 22 rming rme VBG cord-024189-t7mbsr25 843 23 the the DT cord-024189-t7mbsr25 843 24 diagnosis diagnosis NN cord-024189-t7mbsr25 843 25 . . . cord-024189-t7mbsr25 844 1 Light light JJ cord-024189-t7mbsr25 844 2 microscopy microscopy NNS cord-024189-t7mbsr25 844 3 of of IN cord-024189-t7mbsr25 844 4 purpuric purpuric JJ cord-024189-t7mbsr25 844 5 lesions lesion NNS cord-024189-t7mbsr25 844 6 demonstrates demonstrate VBZ cord-024189-t7mbsr25 844 7 leukocytoclastic leukocytoclastic JJ cord-024189-t7mbsr25 844 8 vasculitis vasculitis NN cord-024189-t7mbsr25 844 9 . . . cord-024189-t7mbsr25 845 1 Direct direct JJ cord-024189-t7mbsr25 845 2 immuno immuno JJ cord-024189-t7mbsr25 845 3 fl fl NNP cord-024189-t7mbsr25 845 4 uorescence uorescence NN cord-024189-t7mbsr25 845 5 studies study NNS cord-024189-t7mbsr25 845 6 reveal reveal VBP cord-024189-t7mbsr25 845 7 various various JJ cord-024189-t7mbsr25 845 8 types type NNS cord-024189-t7mbsr25 845 9 of of IN cord-024189-t7mbsr25 845 10 immunoglobulin immunoglobulin NN cord-024189-t7mbsr25 845 11 and and CC cord-024189-t7mbsr25 845 12 complement complement JJ cord-024189-t7mbsr25 845 13 deposition deposition NN cord-024189-t7mbsr25 845 14 , , , cord-024189-t7mbsr25 845 15 depending depend VBG cord-024189-t7mbsr25 845 16 on on IN cord-024189-t7mbsr25 845 17 cryoglobulinemia cryoglobulinemia NN cord-024189-t7mbsr25 845 18 type type NN cord-024189-t7mbsr25 845 19 . . . cord-024189-t7mbsr25 846 1 In in IN cord-024189-t7mbsr25 846 2 type type NN cord-024189-t7mbsr25 846 3 II II NNP cord-024189-t7mbsr25 846 4 cryoglobulinemia cryoglobulinemia NN cord-024189-t7mbsr25 846 5 , , , cord-024189-t7mbsr25 846 6 for for IN cord-024189-t7mbsr25 846 7 example example NN cord-024189-t7mbsr25 846 8 , , , cord-024189-t7mbsr25 846 9 direct direct JJ cord-024189-t7mbsr25 846 10 immunofl immunofl NN cord-024189-t7mbsr25 846 11 uorescence uorescence NNP cord-024189-t7mbsr25 846 12 reveals reveal VBZ cord-024189-t7mbsr25 846 13 IgG IgG NNP cord-024189-t7mbsr25 846 14 and and CC cord-024189-t7mbsr25 846 15 IgM IgM NNP cord-024189-t7mbsr25 846 16 deposition deposition NNP cord-024189-t7mbsr25 846 17 , , , cord-024189-t7mbsr25 846 18 as as RB cord-024189-t7mbsr25 846 19 well well RB cord-024189-t7mbsr25 846 20 as as IN cord-024189-t7mbsr25 846 21 complement complement JJ cord-024189-t7mbsr25 846 22 components component NNS cord-024189-t7mbsr25 846 23 . . . cord-024189-t7mbsr25 847 1 Renal renal JJ cord-024189-t7mbsr25 847 2 biopsies biopsy NNS cord-024189-t7mbsr25 847 3 from from IN cord-024189-t7mbsr25 847 4 patients patient NNS cord-024189-t7mbsr25 847 5 with with IN cord-024189-t7mbsr25 847 6 glomerulonephritis glomerulonephritis NN cord-024189-t7mbsr25 847 7 caused cause VBN cord-024189-t7mbsr25 847 8 by by IN cord-024189-t7mbsr25 847 9 cryoglobulinemia cryoglobulinemia NNP cord-024189-t7mbsr25 847 10 reveal reveal VBP cord-024189-t7mbsr25 847 11 a a DT cord-024189-t7mbsr25 847 12 membranoproliferative membranoproliferative JJ cord-024189-t7mbsr25 847 13 glomerulonephritis glomerulonephritis NN cord-024189-t7mbsr25 847 14 that that WDT cord-024189-t7mbsr25 847 15 must must MD cord-024189-t7mbsr25 847 16 be be VB cord-024189-t7mbsr25 847 17 distinguished distinguish VBN cord-024189-t7mbsr25 847 18 from from IN cord-024189-t7mbsr25 847 19 lupus lupus NN cord-024189-t7mbsr25 847 20 nephritis nephritis NN cord-024189-t7mbsr25 847 21 ( ( -LRB- cord-024189-t7mbsr25 847 22 another another DT cord-024189-t7mbsr25 847 23 disorder disorder NN cord-024189-t7mbsr25 847 24 in in IN cord-024189-t7mbsr25 847 25 which which WDT cord-024189-t7mbsr25 847 26 immune immune JJ cord-024189-t7mbsr25 847 27 complexes complex NNS cord-024189-t7mbsr25 847 28 play play VBP cord-024189-t7mbsr25 847 29 a a DT cord-024189-t7mbsr25 847 30 major major JJ cord-024189-t7mbsr25 847 31 role role NN cord-024189-t7mbsr25 847 32 ) ) -RRB- cord-024189-t7mbsr25 847 33 . . . cord-024189-t7mbsr25 848 1 If if IN cord-024189-t7mbsr25 848 2 biopsy biopsy NN cord-024189-t7mbsr25 848 3 is be VBZ cord-024189-t7mbsr25 848 4 impractical impractical JJ cord-024189-t7mbsr25 848 5 or or CC cord-024189-t7mbsr25 848 6 impossible impossible JJ cord-024189-t7mbsr25 848 7 , , , cord-024189-t7mbsr25 848 8 serologic serologic JJ cord-024189-t7mbsr25 848 9 testing testing NN cord-024189-t7mbsr25 848 10 may may MD cord-024189-t7mbsr25 848 11 be be VB cord-024189-t7mbsr25 848 12 helpful helpful JJ cord-024189-t7mbsr25 848 13 . . . cord-024189-t7mbsr25 849 1 The the DT cord-024189-t7mbsr25 849 2 most most RBS cord-024189-t7mbsr25 849 3 directly directly RB cord-024189-t7mbsr25 849 4 relevant relevant JJ cord-024189-t7mbsr25 849 5 test test NN cord-024189-t7mbsr25 849 6 is be VBZ cord-024189-t7mbsr25 849 7 a a DT cord-024189-t7mbsr25 849 8 serum serum NN cord-024189-t7mbsr25 849 9 cryoglobulin cryoglobulin JJ cord-024189-t7mbsr25 849 10 assay assay NN cord-024189-t7mbsr25 849 11 , , , cord-024189-t7mbsr25 849 12 which which WDT cord-024189-t7mbsr25 849 13 can can MD cord-024189-t7mbsr25 849 14 give give VB cord-024189-t7mbsr25 849 15 a a DT cord-024189-t7mbsr25 849 16 direct direct JJ cord-024189-t7mbsr25 849 17 sense sense NN cord-024189-t7mbsr25 849 18 of of IN cord-024189-t7mbsr25 849 19 the the DT cord-024189-t7mbsr25 849 20 burden burden NN cord-024189-t7mbsr25 849 21 of of IN cord-024189-t7mbsr25 849 22 disease disease NN cord-024189-t7mbsr25 849 23 . . . cord-024189-t7mbsr25 850 1 The the DT cord-024189-t7mbsr25 850 2 serum serum NN cord-024189-t7mbsr25 850 3 is be VBZ cord-024189-t7mbsr25 850 4 allowed allow VBN cord-024189-t7mbsr25 850 5 to to TO cord-024189-t7mbsr25 850 6 remain remain VB cord-024189-t7mbsr25 850 7 at at IN cord-024189-t7mbsr25 850 8 4 4 CD cord-024189-t7mbsr25 850 9 ° ° NN cord-024189-t7mbsr25 850 10 C c NN cord-024189-t7mbsr25 850 11 for for IN cord-024189-t7mbsr25 850 12 several several JJ cord-024189-t7mbsr25 850 13 days day NNS cord-024189-t7mbsr25 850 14 before before IN cord-024189-t7mbsr25 850 15 interpretation interpretation NN cord-024189-t7mbsr25 850 16 . . . cord-024189-t7mbsr25 851 1 The the DT cord-024189-t7mbsr25 851 2 percentage percentage NN cord-024189-t7mbsr25 851 3 of of IN cord-024189-t7mbsr25 851 4 the the DT cord-024189-t7mbsr25 851 5 serum serum NN cord-024189-t7mbsr25 851 6 occupied occupy VBN cord-024189-t7mbsr25 851 7 by by IN cord-024189-t7mbsr25 851 8 the the DT cord-024189-t7mbsr25 851 9 cryoprecipitate cryoprecipitate NN cord-024189-t7mbsr25 851 10 is be VBZ cord-024189-t7mbsr25 851 11 commonly commonly RB cord-024189-t7mbsr25 851 12 referred refer VBN cord-024189-t7mbsr25 851 13 to to IN cord-024189-t7mbsr25 851 14 as as IN cord-024189-t7mbsr25 851 15 the the DT cord-024189-t7mbsr25 851 16 cryocrit cryocrit NNP cord-024189-t7mbsr25 851 17 , , , cord-024189-t7mbsr25 851 18 and and CC cord-024189-t7mbsr25 851 19 may may MD cord-024189-t7mbsr25 851 20 be be VB cord-024189-t7mbsr25 851 21 useful useful JJ cord-024189-t7mbsr25 851 22 for for IN cord-024189-t7mbsr25 851 23 following follow VBG cord-024189-t7mbsr25 851 24 such such JJ cord-024189-t7mbsr25 851 25 patients patient NNS cord-024189-t7mbsr25 851 26 longitudinally longitudinally RB cord-024189-t7mbsr25 851 27 . . . cord-024189-t7mbsr25 852 1 Serum serum NN cord-024189-t7mbsr25 852 2 cryoglobulin cryoglobulin JJ cord-024189-t7mbsr25 852 3 tests test NNS cord-024189-t7mbsr25 852 4 are be VBP cord-024189-t7mbsr25 852 5 , , , cord-024189-t7mbsr25 852 6 unfortunately unfortunately RB cord-024189-t7mbsr25 852 7 , , , cord-024189-t7mbsr25 852 8 notoriously notoriously RB cord-024189-t7mbsr25 852 9 diffi diffi JJ cord-024189-t7mbsr25 852 10 cult cult NN cord-024189-t7mbsr25 852 11 to to TO cord-024189-t7mbsr25 852 12 obtain obtain VB cord-024189-t7mbsr25 852 13 , , , cord-024189-t7mbsr25 852 14 largely largely RB cord-024189-t7mbsr25 852 15 because because IN cord-024189-t7mbsr25 852 16 the the DT cord-024189-t7mbsr25 852 17 collection collection NN cord-024189-t7mbsr25 852 18 apparatus apparatus NN cord-024189-t7mbsr25 852 19 must must MD cord-024189-t7mbsr25 852 20 be be VB cord-024189-t7mbsr25 852 21 prewarmed prewarme VBN cord-024189-t7mbsr25 852 22 and and CC cord-024189-t7mbsr25 852 23 the the DT cord-024189-t7mbsr25 852 24 blood blood NN cord-024189-t7mbsr25 852 25 must must MD cord-024189-t7mbsr25 852 26 be be VB cord-024189-t7mbsr25 852 27 allowed allow VBN cord-024189-t7mbsr25 852 28 to to TO cord-024189-t7mbsr25 852 29 clot clot VB cord-024189-t7mbsr25 852 30 at at IN cord-024189-t7mbsr25 852 31 37 37 CD cord-024189-t7mbsr25 852 32 ° ° NN cord-024189-t7mbsr25 852 33 C c NN cord-024189-t7mbsr25 852 34 before before IN cord-024189-t7mbsr25 852 35 processing processing NN cord-024189-t7mbsr25 852 36 . . . cord-024189-t7mbsr25 853 1 Falsenegative falsenegative JJ cord-024189-t7mbsr25 853 2 assays assay NNS cord-024189-t7mbsr25 853 3 for for IN cord-024189-t7mbsr25 853 4 cryoglobulins cryoglobulin NNS cord-024189-t7mbsr25 853 5 are be VBP cord-024189-t7mbsr25 853 6 common common JJ cord-024189-t7mbsr25 853 7 , , , cord-024189-t7mbsr25 853 8 particularly particularly RB cord-024189-t7mbsr25 853 9 in in IN cord-024189-t7mbsr25 853 10 laboratories laboratory NNS cord-024189-t7mbsr25 853 11 not not RB cord-024189-t7mbsr25 853 12 experienced experience VBN cord-024189-t7mbsr25 853 13 in in IN cord-024189-t7mbsr25 853 14 the the DT cord-024189-t7mbsr25 853 15 collection collection NN cord-024189-t7mbsr25 853 16 and and CC cord-024189-t7mbsr25 853 17 processing processing NN cord-024189-t7mbsr25 853 18 of of IN cord-024189-t7mbsr25 853 19 samples sample NNS cord-024189-t7mbsr25 853 20 . . . cord-024189-t7mbsr25 854 1 For for IN cord-024189-t7mbsr25 854 2 patients patient NNS cord-024189-t7mbsr25 854 3 with with IN cord-024189-t7mbsr25 854 4 type type NN cord-024189-t7mbsr25 854 5 II ii NN cord-024189-t7mbsr25 854 6 and and CC cord-024189-t7mbsr25 854 7 type type NN cord-024189-t7mbsr25 854 8 III iii CD cord-024189-t7mbsr25 854 9 cryoglobulinemia cryoglobulinemia NN cord-024189-t7mbsr25 854 10 , , , cord-024189-t7mbsr25 854 11 nonspecifi nonspecifi NNP cord-024189-t7mbsr25 854 12 c c NNP cord-024189-t7mbsr25 854 13 serologic serologic NNP cord-024189-t7mbsr25 854 14 testing testing NN cord-024189-t7mbsr25 854 15 may may MD cord-024189-t7mbsr25 854 16 also also RB cord-024189-t7mbsr25 854 17 heighten heighten VB cord-024189-t7mbsr25 854 18 suspicion suspicion NN cord-024189-t7mbsr25 854 19 . . . cord-024189-t7mbsr25 855 1 First first RB cord-024189-t7mbsr25 855 2 , , , cord-024189-t7mbsr25 855 3 a a DT cord-024189-t7mbsr25 855 4 strong strong JJ cord-024189-t7mbsr25 855 5 clue clue NN cord-024189-t7mbsr25 855 6 to to IN cord-024189-t7mbsr25 855 7 the the DT cord-024189-t7mbsr25 855 8 presence presence NN cord-024189-t7mbsr25 855 9 of of IN cord-024189-t7mbsr25 855 10 mixed mix VBN cord-024189-t7mbsr25 855 11 cryoglobulinemia cryoglobulinemia NN cord-024189-t7mbsr25 855 12 is be VBZ cord-024189-t7mbsr25 855 13 an an DT cord-024189-t7mbsr25 855 14 extremely extremely RB cord-024189-t7mbsr25 855 15 low low JJ cord-024189-t7mbsr25 855 16 ( ( -LRB- cord-024189-t7mbsr25 855 17 to to IN cord-024189-t7mbsr25 855 18 almost almost RB cord-024189-t7mbsr25 855 19 undetectable undetectable JJ cord-024189-t7mbsr25 855 20 ) ) -RRB- cord-024189-t7mbsr25 855 21 level level NN cord-024189-t7mbsr25 855 22 of of IN cord-024189-t7mbsr25 855 23 C4 c4 NN cord-024189-t7mbsr25 855 24 . . . cord-024189-t7mbsr25 856 1 For for IN cord-024189-t7mbsr25 856 2 reasons reason NNS cord-024189-t7mbsr25 856 3 that that WDT cord-024189-t7mbsr25 856 4 are be VBP cord-024189-t7mbsr25 856 5 not not RB cord-024189-t7mbsr25 856 6 entirely entirely RB cord-024189-t7mbsr25 856 7 clear clear JJ cord-024189-t7mbsr25 856 8 , , , cord-024189-t7mbsr25 856 9 C4 c4 NN cord-024189-t7mbsr25 856 10 levels level NNS cord-024189-t7mbsr25 856 11 are be VBP cord-024189-t7mbsr25 856 12 lowered lower VBN cord-024189-t7mbsr25 856 13 out out IN cord-024189-t7mbsr25 856 14 of of IN cord-024189-t7mbsr25 856 15 proportion proportion NN cord-024189-t7mbsr25 856 16 to to IN cord-024189-t7mbsr25 856 17 the the DT cord-024189-t7mbsr25 856 18 decrease decrease NN cord-024189-t7mbsr25 856 19 observed observe VBN cord-024189-t7mbsr25 856 20 in in IN cord-024189-t7mbsr25 856 21 C3 C3 NNP cord-024189-t7mbsr25 856 22 . . . cord-024189-t7mbsr25 857 1 Second second RB cord-024189-t7mbsr25 857 2 , , , cord-024189-t7mbsr25 857 3 the the DT cord-024189-t7mbsr25 857 4 monoclonal monoclonal JJ cord-024189-t7mbsr25 857 5 component component NN cord-024189-t7mbsr25 857 6 of of IN cord-024189-t7mbsr25 857 7 type type NN cord-024189-t7mbsr25 857 8 II ii CD cord-024189-t7mbsr25 857 9 cryoglobulins cryoglobulin NNS cord-024189-t7mbsr25 857 10 almost almost RB cord-024189-t7mbsr25 857 11 invariably invariably RB cord-024189-t7mbsr25 857 12 has have VBZ cord-024189-t7mbsr25 857 13 rheumatoid rheumatoid NN cord-024189-t7mbsr25 857 14 factor factor NN cord-024189-t7mbsr25 857 15 activity activity NN cord-024189-t7mbsr25 858 1 ( ( -LRB- cord-024189-t7mbsr25 858 2 i.e. i.e. FW cord-024189-t7mbsr25 858 3 , , , cord-024189-t7mbsr25 858 4 binds bind VBZ cord-024189-t7mbsr25 858 5 to to IN cord-024189-t7mbsr25 858 6 the the DT cord-024189-t7mbsr25 858 7 Fc Fc NNP cord-024189-t7mbsr25 858 8 portion portion NN cord-024189-t7mbsr25 858 9 of of IN cord-024189-t7mbsr25 858 10 IgG IgG NNP cord-024189-t7mbsr25 858 11 ) ) -RRB- cord-024189-t7mbsr25 858 12 . . . cord-024189-t7mbsr25 859 1 Thus thus RB cord-024189-t7mbsr25 859 2 , , , cord-024189-t7mbsr25 859 3 essentially essentially RB cord-024189-t7mbsr25 859 4 all all DT cord-024189-t7mbsr25 859 5 patients patient NNS cord-024189-t7mbsr25 859 6 with with IN cord-024189-t7mbsr25 859 7 type type NN cord-024189-t7mbsr25 859 8 II II NNP cord-024189-t7mbsr25 859 9 cryoglobulinemia cryoglobulinemia NN cord-024189-t7mbsr25 859 10 are be VBP cord-024189-t7mbsr25 859 11 rheumatoid rheumatoid NN cord-024189-t7mbsr25 859 12 factor factor NN cord-024189-t7mbsr25 859 13 - - HYPH cord-024189-t7mbsr25 859 14 positive positive JJ cord-024189-t7mbsr25 859 15 - - : cord-024189-t7mbsr25 859 16 usually usually RB cord-024189-t7mbsr25 859 17 strikingly strikingly RB cord-024189-t7mbsr25 859 18 so so RB cord-024189-t7mbsr25 859 19 . . . cord-024189-t7mbsr25 860 1 In in IN cord-024189-t7mbsr25 860 2 many many JJ cord-024189-t7mbsr25 860 3 cases case NNS cord-024189-t7mbsr25 860 4 , , , cord-024189-t7mbsr25 860 5 rheumatoid rheumatoid NN cord-024189-t7mbsr25 860 6 factor factor NN cord-024189-t7mbsr25 860 7 tests test NNS cord-024189-t7mbsr25 860 8 are be VBP cord-024189-t7mbsr25 860 9 a a DT cord-024189-t7mbsr25 860 10 more more RBR cord-024189-t7mbsr25 860 11 reliable reliable JJ cord-024189-t7mbsr25 860 12 screening screening NN cord-024189-t7mbsr25 860 13 test test NN cord-024189-t7mbsr25 860 14 for for IN cord-024189-t7mbsr25 860 15 type type NN cord-024189-t7mbsr25 860 16 II II NNP cord-024189-t7mbsr25 860 17 cryoglobulinemia cryoglobulinemia NN cord-024189-t7mbsr25 860 18 than than IN cord-024189-t7mbsr25 860 19 are be VBP cord-024189-t7mbsr25 860 20 assays assay NNS cord-024189-t7mbsr25 860 21 for for IN cord-024189-t7mbsr25 860 22 cryoglobulins cryoglobulin NNS cord-024189-t7mbsr25 860 23 themselves -PRON- PRP cord-024189-t7mbsr25 860 24 . . . cord-024189-t7mbsr25 861 1 Although although IN cord-024189-t7mbsr25 861 2 rheumatoid rheumatoid NN cord-024189-t7mbsr25 861 3 factor factor NN cord-024189-t7mbsr25 861 4 titers titer NNS cord-024189-t7mbsr25 861 5 correlate correlate VBP cord-024189-t7mbsr25 861 6 with with IN cord-024189-t7mbsr25 861 7 immunoglobulin immunoglobulin NN cord-024189-t7mbsr25 861 8 burden burden NN cord-024189-t7mbsr25 861 9 in in IN cord-024189-t7mbsr25 861 10 such such JJ cord-024189-t7mbsr25 861 11 patients patient NNS cord-024189-t7mbsr25 861 12 and and CC cord-024189-t7mbsr25 861 13 can can MD cord-024189-t7mbsr25 861 14 be be VB cord-024189-t7mbsr25 861 15 used use VBN cord-024189-t7mbsr25 861 16 in in IN cord-024189-t7mbsr25 861 17 longitudinal longitudinal JJ cord-024189-t7mbsr25 861 18 follow follow NN cord-024189-t7mbsr25 861 19 - - HYPH cord-024189-t7mbsr25 861 20 up up NN cord-024189-t7mbsr25 861 21 in in IN cord-024189-t7mbsr25 861 22 a a DT cord-024189-t7mbsr25 861 23 manner manner NN cord-024189-t7mbsr25 861 24 similar similar JJ cord-024189-t7mbsr25 861 25 to to IN cord-024189-t7mbsr25 861 26 the the DT cord-024189-t7mbsr25 861 27 cryocrit cryocrit NNP cord-024189-t7mbsr25 861 28 , , , cord-024189-t7mbsr25 861 29 the the DT cord-024189-t7mbsr25 861 30 level level NN cord-024189-t7mbsr25 861 31 of of IN cord-024189-t7mbsr25 861 32 clinical clinical JJ cord-024189-t7mbsr25 861 33 symptomatology symptomatology NN cord-024189-t7mbsr25 861 34 often often RB cord-024189-t7mbsr25 861 35 correlates correlate VBZ cord-024189-t7mbsr25 861 36 poorly poorly RB cord-024189-t7mbsr25 861 37 with with IN cord-024189-t7mbsr25 861 38 both both DT cord-024189-t7mbsr25 861 39 rheumatoid rheumatoid NN cord-024189-t7mbsr25 861 40 factor factor NN cord-024189-t7mbsr25 861 41 level level NN cord-024189-t7mbsr25 861 42 and and CC cord-024189-t7mbsr25 861 43 cryocrit cryocrit NNP cord-024189-t7mbsr25 861 44 . . . cord-024189-t7mbsr25 862 1 Once once IN cord-024189-t7mbsr25 862 2 patients patient NNS cord-024189-t7mbsr25 862 3 have have VBP cord-024189-t7mbsr25 862 4 achieved achieve VBN cord-024189-t7mbsr25 862 5 a a DT cord-024189-t7mbsr25 862 6 state state NN cord-024189-t7mbsr25 862 7 of of IN cord-024189-t7mbsr25 862 8 disease disease NN cord-024189-t7mbsr25 862 9 quiescence quiescence NN cord-024189-t7mbsr25 862 10 following follow VBG cord-024189-t7mbsr25 862 11 treatment treatment NN cord-024189-t7mbsr25 862 12 , , , cord-024189-t7mbsr25 862 13 both both DT cord-024189-t7mbsr25 862 14 rheumatoid rheumatoid NN cord-024189-t7mbsr25 862 15 factor factor NN cord-024189-t7mbsr25 862 16 levels level NNS cord-024189-t7mbsr25 862 17 and and CC cord-024189-t7mbsr25 862 18 cryocrit cryocrit NNP cord-024189-t7mbsr25 862 19 often often RB cord-024189-t7mbsr25 862 20 remain remain VBP cord-024189-t7mbsr25 862 21 elevated elevated JJ cord-024189-t7mbsr25 862 22 . . . cord-024189-t7mbsr25 863 1 Neither neither DT cord-024189-t7mbsr25 863 2 should should MD cord-024189-t7mbsr25 863 3 be be VB cord-024189-t7mbsr25 863 4 used use VBN cord-024189-t7mbsr25 863 5 as as IN cord-024189-t7mbsr25 863 6 a a DT cord-024189-t7mbsr25 863 7 gauge gauge NN cord-024189-t7mbsr25 863 8 of of IN cord-024189-t7mbsr25 863 9 therapy therapy NN cord-024189-t7mbsr25 863 10 for for IN cord-024189-t7mbsr25 863 11 most most JJS cord-024189-t7mbsr25 863 12 patients patient NNS cord-024189-t7mbsr25 863 13 . . . cord-024189-t7mbsr25 864 1 Finally finally RB cord-024189-t7mbsr25 864 2 , , , cord-024189-t7mbsr25 864 3 acute acute JJ cord-024189-t7mbsr25 864 4 - - HYPH cord-024189-t7mbsr25 864 5 phase phase NN cord-024189-t7mbsr25 864 6 reactants reactant NNS cord-024189-t7mbsr25 864 7 such such JJ cord-024189-t7mbsr25 864 8 as as IN cord-024189-t7mbsr25 864 9 the the DT cord-024189-t7mbsr25 864 10 erythrocyte erythrocyte NN cord-024189-t7mbsr25 864 11 sedimentation sedimentation NN cord-024189-t7mbsr25 864 12 rate rate NN cord-024189-t7mbsr25 864 13 and and CC cord-024189-t7mbsr25 864 14 the the DT cord-024189-t7mbsr25 864 15 C C NNP cord-024189-t7mbsr25 864 16 - - HYPH cord-024189-t7mbsr25 864 17 reactive reactive JJ cord-024189-t7mbsr25 864 18 protein protein NN cord-024189-t7mbsr25 864 19 are be VBP cord-024189-t7mbsr25 864 20 elevated elevate VBN cord-024189-t7mbsr25 864 21 in in IN cord-024189-t7mbsr25 864 22 many many JJ cord-024189-t7mbsr25 864 23 patients patient NNS cord-024189-t7mbsr25 864 24 with with IN cord-024189-t7mbsr25 864 25 cryoglobulinemia cryoglobulinemia NN cord-024189-t7mbsr25 864 26 . . . cord-024189-t7mbsr25 865 1 In in IN cord-024189-t7mbsr25 865 2 patients patient NNS cord-024189-t7mbsr25 865 3 with with IN cord-024189-t7mbsr25 865 4 type type NN cord-024189-t7mbsr25 865 5 I -PRON- PRP cord-024189-t7mbsr25 865 6 cryoglobulinemia cryoglobulinemia NN cord-024189-t7mbsr25 865 7 , , , cord-024189-t7mbsr25 865 8 for for IN cord-024189-t7mbsr25 865 9 example example NN cord-024189-t7mbsr25 865 10 , , , cord-024189-t7mbsr25 865 11 the the DT cord-024189-t7mbsr25 865 12 erythrocyte erythrocyte NN cord-024189-t7mbsr25 865 13 sedimentation sedimentation NN cord-024189-t7mbsr25 865 14 rate rate NN cord-024189-t7mbsr25 865 15 may may MD cord-024189-t7mbsr25 865 16 be be VB cord-024189-t7mbsr25 865 17 even even RB cord-024189-t7mbsr25 865 18 higher high JJR cord-024189-t7mbsr25 865 19 than than IN cord-024189-t7mbsr25 865 20 anticipated anticipate VBN cord-024189-t7mbsr25 865 21 because because IN cord-024189-t7mbsr25 865 22 of of IN cord-024189-t7mbsr25 865 23 the the DT cord-024189-t7mbsr25 865 24 excess excess JJ cord-024189-t7mbsr25 865 25 circulating circulate VBG cord-024189-t7mbsr25 865 26 immunoglobulin immunoglobulin NN cord-024189-t7mbsr25 865 27 . . . cord-024189-t7mbsr25 866 1 Treatment treatment NN cord-024189-t7mbsr25 866 2 of of IN cord-024189-t7mbsr25 866 3 the the DT cord-024189-t7mbsr25 866 4 underlying underlying JJ cord-024189-t7mbsr25 866 5 cause cause NN cord-024189-t7mbsr25 866 6 of of IN cord-024189-t7mbsr25 866 7 the the DT cord-024189-t7mbsr25 866 8 cryoglobulins cryoglobulin NNS cord-024189-t7mbsr25 866 9 is be VBZ cord-024189-t7mbsr25 866 10 the the DT cord-024189-t7mbsr25 866 11 only only JJ cord-024189-t7mbsr25 866 12 approach approach NN cord-024189-t7mbsr25 866 13 that that WDT cord-024189-t7mbsr25 866 14 may may MD cord-024189-t7mbsr25 866 15 lead lead VB cord-024189-t7mbsr25 866 16 to to IN cord-024189-t7mbsr25 866 17 long long JJ cord-024189-t7mbsr25 866 18 - - HYPH cord-024189-t7mbsr25 866 19 term term NN cord-024189-t7mbsr25 866 20 response response NN cord-024189-t7mbsr25 866 21 . . . cord-024189-t7mbsr25 867 1 Immunosuppression Immunosuppression NNP cord-024189-t7mbsr25 867 2 alone alone RB cord-024189-t7mbsr25 867 3 will will MD cord-024189-t7mbsr25 867 4 not not RB cord-024189-t7mbsr25 867 5 be be VB cord-024189-t7mbsr25 867 6 suffi suffi NNP cord-024189-t7mbsr25 867 7 cient cient NNP cord-024189-t7mbsr25 867 8 to to TO cord-024189-t7mbsr25 867 9 treat treat VB cord-024189-t7mbsr25 867 10 a a DT cord-024189-t7mbsr25 867 11 cryoglobulinemic cryoglobulinemic JJ cord-024189-t7mbsr25 867 12 vasculitis vasculitis NN cord-024189-t7mbsr25 867 13 that that WDT cord-024189-t7mbsr25 867 14 is be VBZ cord-024189-t7mbsr25 867 15 driven drive VBN cord-024189-t7mbsr25 867 16 by by IN cord-024189-t7mbsr25 867 17 malignancy malignancy NN cord-024189-t7mbsr25 867 18 or or CC cord-024189-t7mbsr25 867 19 chronic chronic JJ cord-024189-t7mbsr25 867 20 infection infection NN cord-024189-t7mbsr25 867 21 . . . cord-024189-t7mbsr25 868 1 In in IN cord-024189-t7mbsr25 868 2 the the DT cord-024189-t7mbsr25 868 3 case case NN cord-024189-t7mbsr25 868 4 of of IN cord-024189-t7mbsr25 868 5 hepatitis hepatitis NN cord-024189-t7mbsr25 868 6 Cassociated Cassociated NNP cord-024189-t7mbsr25 868 7 cryoglobulinemic cryoglobulinemic NNP cord-024189-t7mbsr25 868 8 vasculitis vasculitis NN cord-024189-t7mbsr25 868 9 , , , cord-024189-t7mbsr25 868 10 for for IN cord-024189-t7mbsr25 868 11 example example NN cord-024189-t7mbsr25 868 12 , , , cord-024189-t7mbsr25 868 13 the the DT cord-024189-t7mbsr25 868 14 optimal optimal JJ cord-024189-t7mbsr25 868 15 therapy therapy NN cord-024189-t7mbsr25 868 16 consists consist VBZ cord-024189-t7mbsr25 868 17 of of IN cord-024189-t7mbsr25 868 18 the the DT cord-024189-t7mbsr25 868 19 effective effective JJ cord-024189-t7mbsr25 868 20 control control NN cord-024189-t7mbsr25 868 21 of of IN cord-024189-t7mbsr25 868 22 the the DT cord-024189-t7mbsr25 868 23 underlying underlying JJ cord-024189-t7mbsr25 868 24 viral viral JJ cord-024189-t7mbsr25 868 25 infection infection NN cord-024189-t7mbsr25 868 26 ( ( -LRB- cord-024189-t7mbsr25 868 27 typically typically RB cord-024189-t7mbsr25 868 28 with with IN cord-024189-t7mbsr25 868 29 interferonalpha interferonalpha NNP cord-024189-t7mbsr25 868 30 and and CC cord-024189-t7mbsr25 868 31 ribavirin ribavirin NN cord-024189-t7mbsr25 868 32 ) ) -RRB- cord-024189-t7mbsr25 868 33 . . . cord-024189-t7mbsr25 869 1 In in IN cord-024189-t7mbsr25 869 2 patients patient NNS cord-024189-t7mbsr25 869 3 who who WP cord-024189-t7mbsr25 869 4 experience experience VBP cord-024189-t7mbsr25 869 5 severe severe JJ cord-024189-t7mbsr25 869 6 consequences consequence NNS cord-024189-t7mbsr25 869 7 of of IN cord-024189-t7mbsr25 869 8 cryoglobulinemia cryoglobulinemia NN cord-024189-t7mbsr25 869 9 ( ( -LRB- cord-024189-t7mbsr25 869 10 such such JJ cord-024189-t7mbsr25 869 11 as as IN cord-024189-t7mbsr25 869 12 mononeuritis mononeuritis NNP cord-024189-t7mbsr25 869 13 multiplex multiplex NN cord-024189-t7mbsr25 869 14 , , , cord-024189-t7mbsr25 869 15 glomerulonephritis glomerulonephritis NN cord-024189-t7mbsr25 869 16 , , , cord-024189-t7mbsr25 869 17 or or CC cord-024189-t7mbsr25 869 18 other other JJ cord-024189-t7mbsr25 869 19 forms form NNS cord-024189-t7mbsr25 869 20 of of IN cord-024189-t7mbsr25 869 21 tissue tissue NN cord-024189-t7mbsr25 869 22 necrosis necrosis NN cord-024189-t7mbsr25 869 23 ) ) -RRB- cord-024189-t7mbsr25 869 24 , , , cord-024189-t7mbsr25 869 25 immunosuppression immunosuppression NN cord-024189-t7mbsr25 869 26 with with IN cord-024189-t7mbsr25 869 27 high high JJ cord-024189-t7mbsr25 869 28 dose dose NN cord-024189-t7mbsr25 869 29 glucocorticoids glucocorticoid NNS cord-024189-t7mbsr25 869 30 and and CC cord-024189-t7mbsr25 869 31 cyclophosphamide cyclophosphamide NN cord-024189-t7mbsr25 869 32 may may MD cord-024189-t7mbsr25 869 33 be be VB cord-024189-t7mbsr25 869 34 necessary necessary JJ cord-024189-t7mbsr25 869 35 to to TO cord-024189-t7mbsr25 869 36 prevent prevent VB cord-024189-t7mbsr25 869 37 further further JJ cord-024189-t7mbsr25 869 38 damage damage NN cord-024189-t7mbsr25 869 39 . . . cord-024189-t7mbsr25 870 1 In in IN cord-024189-t7mbsr25 870 2 patients patient NNS cord-024189-t7mbsr25 870 3 with with IN cord-024189-t7mbsr25 870 4 rampant rampant JJ cord-024189-t7mbsr25 870 5 systemic systemic JJ cord-024189-t7mbsr25 870 6 vasculitis vasculitis NN cord-024189-t7mbsr25 870 7 , , , cord-024189-t7mbsr25 870 8 anecdotal anecdotal JJ cord-024189-t7mbsr25 870 9 evidence evidence NN cord-024189-t7mbsr25 870 10 suggests suggest VBZ cord-024189-t7mbsr25 870 11 that that IN cord-024189-t7mbsr25 870 12 the the DT cord-024189-t7mbsr25 870 13 systemic systemic JJ cord-024189-t7mbsr25 870 14 infl infl NN cord-024189-t7mbsr25 870 15 ammation ammation NN cord-024189-t7mbsr25 870 16 should should MD cord-024189-t7mbsr25 870 17 be be VB cord-024189-t7mbsr25 870 18 controlled control VBN cord-024189-t7mbsr25 870 19 fi fi IN cord-024189-t7mbsr25 870 20 rst rst NN cord-024189-t7mbsr25 870 21 with with IN cord-024189-t7mbsr25 870 22 glucocorticoids glucocorticoid NNS cord-024189-t7mbsr25 870 23 and and CC cord-024189-t7mbsr25 870 24 other other JJ cord-024189-t7mbsr25 870 25 immunosuppressive immunosuppressive JJ cord-024189-t7mbsr25 870 26 agents agent NNS cord-024189-t7mbsr25 870 27 , , , cord-024189-t7mbsr25 870 28 as as IN cord-024189-t7mbsr25 870 29 appropriate appropriate JJ cord-024189-t7mbsr25 870 30 , , , cord-024189-t7mbsr25 870 31 before before IN cord-024189-t7mbsr25 870 32 the the DT cord-024189-t7mbsr25 870 33 institution institution NN cord-024189-t7mbsr25 870 34 of of IN cord-024189-t7mbsr25 870 35 antiviral antiviral JJ cord-024189-t7mbsr25 870 36 therapy therapy NN cord-024189-t7mbsr25 870 37 . . . cord-024189-t7mbsr25 871 1 In in IN cord-024189-t7mbsr25 871 2 some some DT cord-024189-t7mbsr25 871 3 cases case NNS cord-024189-t7mbsr25 871 4 of of IN cord-024189-t7mbsr25 871 5 fl fl NNP cord-024189-t7mbsr25 871 6 agrantly agrantly RB cord-024189-t7mbsr25 871 7 active active JJ cord-024189-t7mbsr25 871 8 vasculitis vasculitis NN cord-024189-t7mbsr25 871 9 , , , cord-024189-t7mbsr25 871 10 the the DT cord-024189-t7mbsr25 871 11 introduction introduction NN cord-024189-t7mbsr25 871 12 of of IN cord-024189-t7mbsr25 871 13 antiviral antiviral JJ cord-024189-t7mbsr25 871 14 therapy therapy NN cord-024189-t7mbsr25 871 15 fi fi NN cord-024189-t7mbsr25 871 16 rst rst NNP cord-024189-t7mbsr25 871 17 is be VBZ cord-024189-t7mbsr25 871 18 believed believe VBN cord-024189-t7mbsr25 871 19 to to TO cord-024189-t7mbsr25 871 20 have have VB cord-024189-t7mbsr25 871 21 triggered trigger VBN cord-024189-t7mbsr25 871 22 disease disease NN cord-024189-t7mbsr25 871 23 exacerbation exacerbation NN cord-024189-t7mbsr25 871 24 through through IN cord-024189-t7mbsr25 871 25 an an DT cord-024189-t7mbsr25 871 26 unfavorable unfavorable JJ cord-024189-t7mbsr25 871 27 alteration alteration NN cord-024189-t7mbsr25 871 28 of of IN cord-024189-t7mbsr25 871 29 the the DT cord-024189-t7mbsr25 871 30 antigen antigen NN cord-024189-t7mbsr25 871 31 / / SYM cord-024189-t7mbsr25 871 32 antibody antibody NN cord-024189-t7mbsr25 871 33 ratio ratio NN cord-024189-t7mbsr25 871 34 . . . cord-024189-t7mbsr25 872 1 The the DT cord-024189-t7mbsr25 872 2 prognosis prognosis NN cord-024189-t7mbsr25 872 3 of of IN cord-024189-t7mbsr25 872 4 patients patient NNS cord-024189-t7mbsr25 872 5 with with IN cord-024189-t7mbsr25 872 6 cryoglobulinemia cryoglobulinemia NNP cord-024189-t7mbsr25 872 7 generally generally RB cord-024189-t7mbsr25 872 8 depends depend VBZ cord-024189-t7mbsr25 872 9 on on IN cord-024189-t7mbsr25 872 10 the the DT cord-024189-t7mbsr25 872 11 underlying underlying JJ cord-024189-t7mbsr25 872 12 cause cause NN cord-024189-t7mbsr25 872 13 . . . cord-024189-t7mbsr25 873 1 The the DT cord-024189-t7mbsr25 873 2 outcome outcome NN cord-024189-t7mbsr25 873 3 of of IN cord-024189-t7mbsr25 873 4 type type NN cord-024189-t7mbsr25 873 5 I -PRON- PRP cord-024189-t7mbsr25 873 6 cryoglobulinemia cryoglobulinemia NN cord-024189-t7mbsr25 873 7 relates relate VBZ cord-024189-t7mbsr25 873 8 closely closely RB cord-024189-t7mbsr25 873 9 to to IN cord-024189-t7mbsr25 873 10 the the DT cord-024189-t7mbsr25 873 11 effi effi NNP cord-024189-t7mbsr25 873 12 cacy cacy NNP cord-024189-t7mbsr25 873 13 in in IN cord-024189-t7mbsr25 873 14 treating treat VBG cord-024189-t7mbsr25 873 15 the the DT cord-024189-t7mbsr25 873 16 cause cause NN cord-024189-t7mbsr25 873 17 of of IN cord-024189-t7mbsr25 873 18 the the DT cord-024189-t7mbsr25 873 19 cryoglobulin cryoglobulin NNP cord-024189-t7mbsr25 873 20 . . . cord-024189-t7mbsr25 874 1 Type Type NNP cord-024189-t7mbsr25 874 2 II II NNP cord-024189-t7mbsr25 874 3 cryoglobulinemia cryoglobulinemia NN cord-024189-t7mbsr25 874 4 secondary secondary JJ cord-024189-t7mbsr25 874 5 to to IN cord-024189-t7mbsr25 874 6 hepatitis hepatitis NN cord-024189-t7mbsr25 874 7 C C NNP cord-024189-t7mbsr25 874 8 may may MD cord-024189-t7mbsr25 874 9 be be VB cord-024189-t7mbsr25 874 10 treated treat VBN cord-024189-t7mbsr25 874 11 effectively effectively RB cord-024189-t7mbsr25 874 12 if if IN cord-024189-t7mbsr25 874 13 the the DT cord-024189-t7mbsr25 874 14 viral viral JJ cord-024189-t7mbsr25 874 15 infection infection NN cord-024189-t7mbsr25 874 16 is be VBZ cord-024189-t7mbsr25 874 17 responsive responsive JJ cord-024189-t7mbsr25 874 18 to to IN cord-024189-t7mbsr25 874 19 therapy therapy NN cord-024189-t7mbsr25 874 20 . . . cord-024189-t7mbsr25 875 1 If if IN cord-024189-t7mbsr25 875 2 patients patient NNS cord-024189-t7mbsr25 875 3 do do VBP cord-024189-t7mbsr25 875 4 not not RB cord-024189-t7mbsr25 875 5 tolerate tolerate VB cord-024189-t7mbsr25 875 6 antiviral antiviral JJ cord-024189-t7mbsr25 875 7 therapy therapy NN cord-024189-t7mbsr25 875 8 well well RB cord-024189-t7mbsr25 875 9 or or CC cord-024189-t7mbsr25 875 10 if if IN cord-024189-t7mbsr25 875 11 the the DT cord-024189-t7mbsr25 875 12 treatment treatment NN cord-024189-t7mbsr25 875 13 is be VBZ cord-024189-t7mbsr25 875 14 ineffective ineffective JJ cord-024189-t7mbsr25 875 15 , , , cord-024189-t7mbsr25 875 16 however however RB cord-024189-t7mbsr25 875 17 , , , cord-024189-t7mbsr25 875 18 some some DT cord-024189-t7mbsr25 875 19 patients patient NNS cord-024189-t7mbsr25 875 20 may may MD cord-024189-t7mbsr25 875 21 require require VB cord-024189-t7mbsr25 875 22 low low JJ cord-024189-t7mbsr25 875 23 - - HYPH cord-024189-t7mbsr25 875 24 to to IN cord-024189-t7mbsr25 875 25 - - HYPH cord-024189-t7mbsr25 875 26 moderate moderate JJ cord-024189-t7mbsr25 875 27 doses dose NNS cord-024189-t7mbsr25 875 28 of of IN cord-024189-t7mbsr25 875 29 prednisone prednisone NNP cord-024189-t7mbsr25 875 30 to to TO cord-024189-t7mbsr25 875 31 control control VB cord-024189-t7mbsr25 875 32 the the DT cord-024189-t7mbsr25 875 33 disease disease NN cord-024189-t7mbsr25 875 34 . . . cord-024189-t7mbsr25 876 1 Type Type NNP cord-024189-t7mbsr25 876 2 III iii CD cord-024189-t7mbsr25 876 3 cryoglobulinemia cryoglobulinemia NN cord-024189-t7mbsr25 876 4 is be VBZ cord-024189-t7mbsr25 876 5 frequently frequently RB cord-024189-t7mbsr25 876 6 a a DT cord-024189-t7mbsr25 876 7 response response NN cord-024189-t7mbsr25 876 8 to to IN cord-024189-t7mbsr25 876 9 an an DT cord-024189-t7mbsr25 876 10 infl infl NN cord-024189-t7mbsr25 876 11 ammatory ammatory NN cord-024189-t7mbsr25 876 12 event event NN cord-024189-t7mbsr25 876 13 ( ( -LRB- cord-024189-t7mbsr25 876 14 such such JJ cord-024189-t7mbsr25 876 15 as as IN cord-024189-t7mbsr25 876 16 infection infection NN cord-024189-t7mbsr25 876 17 ) ) -RRB- cord-024189-t7mbsr25 876 18 , , , cord-024189-t7mbsr25 876 19 and and CC cord-024189-t7mbsr25 876 20 may may MD cord-024189-t7mbsr25 876 21 not not RB cord-024189-t7mbsr25 876 22 require require VB cord-024189-t7mbsr25 876 23 specifi specifi NNP cord-024189-t7mbsr25 876 24 c c NN cord-024189-t7mbsr25 876 25 therapy therapy NN cord-024189-t7mbsr25 876 26 . . . cord-024189-t7mbsr25 877 1 Henoch Henoch NNP cord-024189-t7mbsr25 877 2 - - HYPH cord-024189-t7mbsr25 877 3 Schönlein Schönlein NNP cord-024189-t7mbsr25 877 4 purpura purpura NN cord-024189-t7mbsr25 877 5 ( ( -LRB- cord-024189-t7mbsr25 877 6 HSP HSP NNP cord-024189-t7mbsr25 877 7 ) ) -RRB- cord-024189-t7mbsr25 877 8 is be VBZ cord-024189-t7mbsr25 877 9 an an DT cord-024189-t7mbsr25 877 10 immune immune JJ cord-024189-t7mbsr25 877 11 complex complex NN cord-024189-t7mbsr25 877 12 - - HYPH cord-024189-t7mbsr25 877 13 mediated mediate VBN cord-024189-t7mbsr25 877 14 form form NN cord-024189-t7mbsr25 877 15 of of IN cord-024189-t7mbsr25 877 16 small small JJ cord-024189-t7mbsr25 877 17 vessel vessel NN cord-024189-t7mbsr25 877 18 vasculitis vasculitis NN cord-024189-t7mbsr25 877 19 that that WDT cord-024189-t7mbsr25 877 20 is be VBZ cord-024189-t7mbsr25 877 21 associated associate VBN cord-024189-t7mbsr25 877 22 strongly strongly RB cord-024189-t7mbsr25 877 23 with with IN cord-024189-t7mbsr25 877 24 IgA IgA NNP cord-024189-t7mbsr25 877 25 deposition deposition NN cord-024189-t7mbsr25 877 26 within within IN cord-024189-t7mbsr25 877 27 blood blood NN cord-024189-t7mbsr25 877 28 vessel vessel NN cord-024189-t7mbsr25 877 29 walls wall NNS cord-024189-t7mbsr25 877 30 . . . cord-024189-t7mbsr25 878 1 Many many JJ cord-024189-t7mbsr25 878 2 cases case NNS cord-024189-t7mbsr25 878 3 of of IN cord-024189-t7mbsr25 878 4 HSP HSP NNP cord-024189-t7mbsr25 878 5 are be VBP cord-024189-t7mbsr25 878 6 reported report VBN cord-024189-t7mbsr25 878 7 to to TO cord-024189-t7mbsr25 878 8 occur occur VB cord-024189-t7mbsr25 878 9 after after IN cord-024189-t7mbsr25 878 10 upper upper JJ cord-024189-t7mbsr25 878 11 respiratory respiratory JJ cord-024189-t7mbsr25 878 12 tract tract NN cord-024189-t7mbsr25 878 13 infections infection NNS cord-024189-t7mbsr25 878 14 . . . cord-024189-t7mbsr25 879 1 Group Group NNP cord-024189-t7mbsr25 879 2 A a DT cord-024189-t7mbsr25 879 3 streptococci streptococcus NNS cord-024189-t7mbsr25 879 4 , , , cord-024189-t7mbsr25 879 5 mycoplasma mycoplasma NN cord-024189-t7mbsr25 879 6 , , , cord-024189-t7mbsr25 879 7 Epstein Epstein NNP cord-024189-t7mbsr25 879 8 - - HYPH cord-024189-t7mbsr25 879 9 Barr Barr NNP cord-024189-t7mbsr25 879 10 virus virus NN cord-024189-t7mbsr25 879 11 , , , cord-024189-t7mbsr25 879 12 varicella varicella NN cord-024189-t7mbsr25 879 13 , , , cord-024189-t7mbsr25 879 14 and and CC cord-024189-t7mbsr25 879 15 other other JJ cord-024189-t7mbsr25 879 16 infectious infectious JJ cord-024189-t7mbsr25 879 17 agents agent NNS cord-024189-t7mbsr25 879 18 have have VBP cord-024189-t7mbsr25 879 19 all all DT cord-024189-t7mbsr25 879 20 been be VBN cord-024189-t7mbsr25 879 21 implicated implicate VBN cord-024189-t7mbsr25 879 22 in in IN cord-024189-t7mbsr25 879 23 the the DT cord-024189-t7mbsr25 879 24 pathogenesis pathogenesis NN cord-024189-t7mbsr25 879 25 of of IN cord-024189-t7mbsr25 879 26 this this DT cord-024189-t7mbsr25 879 27 disease disease NN cord-024189-t7mbsr25 879 28 , , , cord-024189-t7mbsr25 879 29 but but CC cord-024189-t7mbsr25 879 30 the the DT cord-024189-t7mbsr25 879 31 true true JJ cord-024189-t7mbsr25 879 32 etiology etiology NN cord-024189-t7mbsr25 879 33 remains remain VBZ cord-024189-t7mbsr25 879 34 unknown unknown JJ cord-024189-t7mbsr25 879 35 . . . cord-024189-t7mbsr25 880 1 In in IN cord-024189-t7mbsr25 880 2 1990 1990 CD cord-024189-t7mbsr25 880 3 , , , cord-024189-t7mbsr25 880 4 the the DT cord-024189-t7mbsr25 880 5 American American NNP cord-024189-t7mbsr25 880 6 College College NNP cord-024189-t7mbsr25 880 7 of of IN cord-024189-t7mbsr25 880 8 Rheumatology Rheumatology NNP cord-024189-t7mbsr25 880 9 proposed propose VBD cord-024189-t7mbsr25 880 10 the the DT cord-024189-t7mbsr25 880 11 following follow VBG cord-024189-t7mbsr25 880 12 criteria criterion NNS cord-024189-t7mbsr25 880 13 for for IN cord-024189-t7mbsr25 880 14 the the DT cord-024189-t7mbsr25 880 15 classifi classifi NNP cord-024189-t7mbsr25 880 16 cation cation NN cord-024189-t7mbsr25 880 17 of of IN cord-024189-t7mbsr25 880 18 HSP HSP NNP cord-024189-t7mbsr25 880 19 ( ( -LRB- cord-024189-t7mbsr25 880 20 6 6 CD cord-024189-t7mbsr25 880 21 ) ) -RRB- cord-024189-t7mbsr25 880 22 : : : cord-024189-t7mbsr25 881 1 • • NNP cord-024189-t7mbsr25 882 1 Palpable palpable JJ cord-024189-t7mbsr25 882 2 purpura purpura NN cord-024189-t7mbsr25 883 1 • • NNP cord-024189-t7mbsr25 884 1 Age age NN cord-024189-t7mbsr25 884 2 ≤ ≤ NNS cord-024189-t7mbsr25 884 3 20 20 CD cord-024189-t7mbsr25 884 4 years year NNS cord-024189-t7mbsr25 884 5 at at IN cord-024189-t7mbsr25 884 6 disease disease NN cord-024189-t7mbsr25 884 7 onset onset NN cord-024189-t7mbsr25 885 1 • • NNP cord-024189-t7mbsr25 886 1 Bowel Bowel NNP cord-024189-t7mbsr25 886 2 angina angina NN cord-024189-t7mbsr25 887 1 • • NNP cord-024189-t7mbsr25 887 2 Granulocytes Granulocytes NNPS cord-024189-t7mbsr25 887 3 in in IN cord-024189-t7mbsr25 887 4 arteriole arteriole NN cord-024189-t7mbsr25 887 5 or or CC cord-024189-t7mbsr25 887 6 venule venule NN cord-024189-t7mbsr25 887 7 walls wall NNS cord-024189-t7mbsr25 887 8 on on IN cord-024189-t7mbsr25 887 9 biopsy biopsy NN cord-024189-t7mbsr25 887 10 Meeting Meeting NNP cord-024189-t7mbsr25 887 11 two two CD cord-024189-t7mbsr25 887 12 of of IN cord-024189-t7mbsr25 887 13 four four CD cord-024189-t7mbsr25 887 14 criteria criterion NNS cord-024189-t7mbsr25 887 15 is be VBZ cord-024189-t7mbsr25 887 16 associated associate VBN cord-024189-t7mbsr25 887 17 with with IN cord-024189-t7mbsr25 887 18 a a DT cord-024189-t7mbsr25 887 19 sensitivity sensitivity NN cord-024189-t7mbsr25 887 20 of of IN cord-024189-t7mbsr25 887 21 87 87 CD cord-024189-t7mbsr25 887 22 % % NN cord-024189-t7mbsr25 887 23 and and CC cord-024189-t7mbsr25 887 24 a a DT cord-024189-t7mbsr25 887 25 specifi specifi JJ cord-024189-t7mbsr25 887 26 city city NN cord-024189-t7mbsr25 887 27 of of IN cord-024189-t7mbsr25 887 28 88 88 CD cord-024189-t7mbsr25 887 29 % % NN cord-024189-t7mbsr25 887 30 for for IN cord-024189-t7mbsr25 887 31 this this DT cord-024189-t7mbsr25 887 32 diagnosis diagnosis NN cord-024189-t7mbsr25 887 33 . . . cord-024189-t7mbsr25 888 1 The the DT cord-024189-t7mbsr25 888 2 hallmarks hallmark NNS cord-024189-t7mbsr25 888 3 of of IN cord-024189-t7mbsr25 888 4 HSP HSP NNP cord-024189-t7mbsr25 888 5 include include VBP cord-024189-t7mbsr25 888 6 an an DT cord-024189-t7mbsr25 888 7 upper upper JJ cord-024189-t7mbsr25 888 8 respiratory respiratory JJ cord-024189-t7mbsr25 888 9 tract tract NN cord-024189-t7mbsr25 888 10 infection infection NN cord-024189-t7mbsr25 888 11 followed follow VBN cord-024189-t7mbsr25 888 12 by by IN cord-024189-t7mbsr25 888 13 a a DT cord-024189-t7mbsr25 888 14 syndrome syndrome NN cord-024189-t7mbsr25 888 15 characterized characterize VBN cord-024189-t7mbsr25 888 16 by by IN cord-024189-t7mbsr25 888 17 a a DT cord-024189-t7mbsr25 888 18 purpuric purpuric NNP cord-024189-t7mbsr25 888 19 rash rash NN cord-024189-t7mbsr25 888 20 , , , cord-024189-t7mbsr25 888 21 arthralgias arthralgias NNP cord-024189-t7mbsr25 888 22 , , , cord-024189-t7mbsr25 888 23 abdominal abdominal JJ cord-024189-t7mbsr25 888 24 pain pain NN cord-024189-t7mbsr25 888 25 , , , cord-024189-t7mbsr25 888 26 and and CC cord-024189-t7mbsr25 888 27 renal renal JJ cord-024189-t7mbsr25 888 28 disease disease NN cord-024189-t7mbsr25 888 29 . . . cord-024189-t7mbsr25 889 1 HSP HSP NNP cord-024189-t7mbsr25 889 2 is be VBZ cord-024189-t7mbsr25 889 3 usually usually RB cord-024189-t7mbsr25 889 4 viewed view VBN cord-024189-t7mbsr25 889 5 as as IN cord-024189-t7mbsr25 889 6 a a DT cord-024189-t7mbsr25 889 7 disease disease NN cord-024189-t7mbsr25 889 8 of of IN cord-024189-t7mbsr25 889 9 childhood childhood NN cord-024189-t7mbsr25 889 10 and and CC cord-024189-t7mbsr25 889 11 , , , cord-024189-t7mbsr25 889 12 indeed indeed RB cord-024189-t7mbsr25 889 13 , , , cord-024189-t7mbsr25 889 14 the the DT cord-024189-t7mbsr25 889 15 majority majority NN cord-024189-t7mbsr25 889 16 of of IN cord-024189-t7mbsr25 889 17 cases case NNS cord-024189-t7mbsr25 889 18 affect affect VBP cord-024189-t7mbsr25 889 19 children child NNS cord-024189-t7mbsr25 889 20 younger young JJR cord-024189-t7mbsr25 889 21 than than IN cord-024189-t7mbsr25 889 22 5 5 CD cord-024189-t7mbsr25 889 23 years year NNS cord-024189-t7mbsr25 889 24 of of IN cord-024189-t7mbsr25 889 25 age age NN cord-024189-t7mbsr25 889 26 . . . cord-024189-t7mbsr25 890 1 Adults adult NNS cord-024189-t7mbsr25 890 2 , , , cord-024189-t7mbsr25 890 3 however however RB cord-024189-t7mbsr25 890 4 , , , cord-024189-t7mbsr25 890 5 can can MD cord-024189-t7mbsr25 890 6 also also RB cord-024189-t7mbsr25 890 7 be be VB cord-024189-t7mbsr25 890 8 affected affect VBN cord-024189-t7mbsr25 890 9 by by IN cord-024189-t7mbsr25 890 10 HSP HSP NNP cord-024189-t7mbsr25 890 11 , , , cord-024189-t7mbsr25 890 12 and and CC cord-024189-t7mbsr25 890 13 have have VBP cord-024189-t7mbsr25 890 14 a a DT cord-024189-t7mbsr25 890 15 greater great JJR cord-024189-t7mbsr25 890 16 tendency tendency NN cord-024189-t7mbsr25 890 17 toward toward IN cord-024189-t7mbsr25 890 18 prolonged prolong VBN cord-024189-t7mbsr25 890 19 disease disease NN cord-024189-t7mbsr25 890 20 courses course NNS cord-024189-t7mbsr25 890 21 ( ( -LRB- cord-024189-t7mbsr25 890 22 with with IN cord-024189-t7mbsr25 890 23 recurrent recurrent JJ cord-024189-t7mbsr25 890 24 bouts bout NNS cord-024189-t7mbsr25 890 25 of of IN cord-024189-t7mbsr25 890 26 purpura purpura NN cord-024189-t7mbsr25 890 27 ) ) -RRB- cord-024189-t7mbsr25 890 28 than than IN cord-024189-t7mbsr25 890 29 do do VB cord-024189-t7mbsr25 890 30 children child NNS cord-024189-t7mbsr25 890 31 ( ( -LRB- cord-024189-t7mbsr25 890 32 7 7 CD cord-024189-t7mbsr25 890 33 ) ) -RRB- cord-024189-t7mbsr25 890 34 . . . cord-024189-t7mbsr25 891 1 Colicky colicky JJ cord-024189-t7mbsr25 891 2 abdominal abdominal JJ cord-024189-t7mbsr25 891 3 pain pain NN cord-024189-t7mbsr25 891 4 , , , cord-024189-t7mbsr25 891 5 presumably presumably RB cord-024189-t7mbsr25 891 6 secondary secondary JJ cord-024189-t7mbsr25 891 7 to to IN cord-024189-t7mbsr25 891 8 gastrointestinal gastrointestinal JJ cord-024189-t7mbsr25 891 9 vasculitis vasculitis NN cord-024189-t7mbsr25 891 10 , , , cord-024189-t7mbsr25 891 11 is be VBZ cord-024189-t7mbsr25 891 12 a a DT cord-024189-t7mbsr25 891 13 common common JJ cord-024189-t7mbsr25 891 14 characteristic characteristic NN cord-024189-t7mbsr25 891 15 of of IN cord-024189-t7mbsr25 891 16 HSP HSP NNP cord-024189-t7mbsr25 891 17 , , , cord-024189-t7mbsr25 891 18 and and CC cord-024189-t7mbsr25 891 19 frequently frequently RB cord-024189-t7mbsr25 891 20 occurs occur VBZ cord-024189-t7mbsr25 891 21 within within IN cord-024189-t7mbsr25 891 22 a a DT cord-024189-t7mbsr25 891 23 week week NN cord-024189-t7mbsr25 891 24 after after IN cord-024189-t7mbsr25 891 25 the the DT cord-024189-t7mbsr25 891 26 onset onset NN cord-024189-t7mbsr25 891 27 of of IN cord-024189-t7mbsr25 891 28 rash rash NN cord-024189-t7mbsr25 891 29 . . . cord-024189-t7mbsr25 892 1 Occasionally occasionally RB cord-024189-t7mbsr25 892 2 the the DT cord-024189-t7mbsr25 892 3 abdominal abdominal JJ cord-024189-t7mbsr25 892 4 pain pain NN cord-024189-t7mbsr25 892 5 in in IN cord-024189-t7mbsr25 892 6 HSP HSP NNP cord-024189-t7mbsr25 892 7 occurs occur VBZ cord-024189-t7mbsr25 892 8 before before IN cord-024189-t7mbsr25 892 9 the the DT cord-024189-t7mbsr25 892 10 onset onset NN cord-024189-t7mbsr25 892 11 of of IN cord-024189-t7mbsr25 892 12 purpura purpura NN cord-024189-t7mbsr25 892 13 , , , cord-024189-t7mbsr25 892 14 and and CC cord-024189-t7mbsr25 892 15 may may MD cord-024189-t7mbsr25 892 16 be be VB cord-024189-t7mbsr25 892 17 diffi diffi NNP cord-024189-t7mbsr25 892 18 cult cult NN cord-024189-t7mbsr25 892 19 to to TO cord-024189-t7mbsr25 892 20 distinguish distinguish VB cord-024189-t7mbsr25 892 21 from from IN cord-024189-t7mbsr25 892 22 an an DT cord-024189-t7mbsr25 892 23 acute acute JJ cord-024189-t7mbsr25 892 24 abdomen abdomen NN cord-024189-t7mbsr25 892 25 . . . cord-024189-t7mbsr25 893 1 Endoscopy Endoscopy NNP cord-024189-t7mbsr25 893 2 may may MD cord-024189-t7mbsr25 893 3 demonstrate demonstrate VB cord-024189-t7mbsr25 893 4 purpura purpura NN cord-024189-t7mbsr25 893 5 in in IN cord-024189-t7mbsr25 893 6 the the DT cord-024189-t7mbsr25 893 7 upper upper JJ cord-024189-t7mbsr25 893 8 or or CC cord-024189-t7mbsr25 893 9 lower low JJR cord-024189-t7mbsr25 893 10 intestinal intestinal JJ cord-024189-t7mbsr25 893 11 tract tract NN cord-024189-t7mbsr25 893 12 . . . cord-024189-t7mbsr25 894 1 Mild mild JJ cord-024189-t7mbsr25 894 2 glomerulonephritis glomerulonephritis NN cord-024189-t7mbsr25 894 3 is be VBZ cord-024189-t7mbsr25 894 4 common common JJ cord-024189-t7mbsr25 894 5 and and CC cord-024189-t7mbsr25 894 6 generally generally RB cord-024189-t7mbsr25 894 7 self self NN cord-024189-t7mbsr25 894 8 - - HYPH cord-024189-t7mbsr25 894 9 limited limit VBN cord-024189-t7mbsr25 894 10 , , , cord-024189-t7mbsr25 894 11 although although IN cord-024189-t7mbsr25 894 12 some some DT cord-024189-t7mbsr25 894 13 patients patient NNS cord-024189-t7mbsr25 894 14 will will MD cord-024189-t7mbsr25 894 15 develop develop VB cord-024189-t7mbsr25 894 16 end end NN cord-024189-t7mbsr25 894 17 - - HYPH cord-024189-t7mbsr25 894 18 stage stage NN cord-024189-t7mbsr25 894 19 renal renal JJ cord-024189-t7mbsr25 894 20 disease disease NN cord-024189-t7mbsr25 894 21 . . . cord-024189-t7mbsr25 895 1 In in IN cord-024189-t7mbsr25 895 2 children child NNS cord-024189-t7mbsr25 895 3 with with IN cord-024189-t7mbsr25 895 4 mild mild JJ cord-024189-t7mbsr25 895 5 manifestations manifestation NNS cord-024189-t7mbsr25 895 6 , , , cord-024189-t7mbsr25 895 7 the the DT cord-024189-t7mbsr25 895 8 clinical clinical JJ cord-024189-t7mbsr25 895 9 history history NN cord-024189-t7mbsr25 895 10 alone alone RB cord-024189-t7mbsr25 895 11 may may MD cord-024189-t7mbsr25 895 12 be be VB cord-024189-t7mbsr25 895 13 suffi suffi NNP cord-024189-t7mbsr25 895 14 cient cient NNP cord-024189-t7mbsr25 895 15 to to IN cord-024189-t7mbsr25 895 16 confi confi NNP cord-024189-t7mbsr25 895 17 rm rm NNP cord-024189-t7mbsr25 895 18 the the DT cord-024189-t7mbsr25 895 19 diagnosis diagnosis NN cord-024189-t7mbsr25 895 20 . . . cord-024189-t7mbsr25 896 1 In in IN cord-024189-t7mbsr25 896 2 more more RBR cord-024189-t7mbsr25 896 3 serious serious JJ cord-024189-t7mbsr25 896 4 cases case NNS cord-024189-t7mbsr25 896 5 or or CC cord-024189-t7mbsr25 896 6 when when WRB cord-024189-t7mbsr25 896 7 there there EX cord-024189-t7mbsr25 896 8 is be VBZ cord-024189-t7mbsr25 896 9 suffi suffi NNP cord-024189-t7mbsr25 896 10 cient cient NNP cord-024189-t7mbsr25 896 11 doubt doubt NN cord-024189-t7mbsr25 896 12 about about IN cord-024189-t7mbsr25 896 13 the the DT cord-024189-t7mbsr25 896 14 diagnosis diagnosis NN cord-024189-t7mbsr25 896 15 , , , cord-024189-t7mbsr25 896 16 biopsy biopsy NN cord-024189-t7mbsr25 896 17 of of IN cord-024189-t7mbsr25 896 18 an an DT cord-024189-t7mbsr25 896 19 involved involved JJ cord-024189-t7mbsr25 896 20 organ organ NN cord-024189-t7mbsr25 896 21 is be VBZ cord-024189-t7mbsr25 896 22 essential essential JJ cord-024189-t7mbsr25 896 23 . . . cord-024189-t7mbsr25 897 1 Unlike unlike IN cord-024189-t7mbsr25 897 2 other other JJ cord-024189-t7mbsr25 897 3 forms form NNS cord-024189-t7mbsr25 897 4 of of IN cord-024189-t7mbsr25 897 5 immune immune JJ cord-024189-t7mbsr25 897 6 complex complex NN cord-024189-t7mbsr25 897 7 - - HYPH cord-024189-t7mbsr25 897 8 mediated mediate VBN cord-024189-t7mbsr25 897 9 disease disease NN cord-024189-t7mbsr25 897 10 , , , cord-024189-t7mbsr25 897 11 however however RB cord-024189-t7mbsr25 897 12 , , , cord-024189-t7mbsr25 897 13 direct direct JJ cord-024189-t7mbsr25 897 14 immunofl immunofl NN cord-024189-t7mbsr25 897 15 uorescence uorescence NN cord-024189-t7mbsr25 897 16 will will MD cord-024189-t7mbsr25 897 17 reveal reveal VB cord-024189-t7mbsr25 897 18 fl fl NNP cord-024189-t7mbsr25 897 19 orid orid NNP cord-024189-t7mbsr25 897 20 IgA IgA NNP cord-024189-t7mbsr25 897 21 deposition deposition NN cord-024189-t7mbsr25 897 22 . . . cord-024189-t7mbsr25 898 1 In in IN cord-024189-t7mbsr25 898 2 the the DT cord-024189-t7mbsr25 898 3 proper proper JJ cord-024189-t7mbsr25 898 4 clinical clinical JJ cord-024189-t7mbsr25 898 5 setting setting NN cord-024189-t7mbsr25 898 6 , , , cord-024189-t7mbsr25 898 7 this this DT cord-024189-t7mbsr25 898 8 fi fi XX cord-024189-t7mbsr25 898 9 nding nding NN cord-024189-t7mbsr25 898 10 is be VBZ cord-024189-t7mbsr25 898 11 diagnostic diagnostic JJ cord-024189-t7mbsr25 898 12 of of IN cord-024189-t7mbsr25 898 13 HSP HSP NNP cord-024189-t7mbsr25 898 14 . . . cord-024189-t7mbsr25 899 1 Other other JJ cord-024189-t7mbsr25 899 2 forms form NNS cord-024189-t7mbsr25 899 3 of of IN cord-024189-t7mbsr25 899 4 small small JJ cord-024189-t7mbsr25 899 5 vessel vessel NN cord-024189-t7mbsr25 899 6 vasculitis vasculitis NN cord-024189-t7mbsr25 899 7 may may MD cord-024189-t7mbsr25 899 8 have have VB cord-024189-t7mbsr25 899 9 small small JJ cord-024189-t7mbsr25 899 10 quantities quantity NNS cord-024189-t7mbsr25 899 11 of of IN cord-024189-t7mbsr25 899 12 IgA iga NN cord-024189-t7mbsr25 899 13 within within IN cord-024189-t7mbsr25 899 14 blood blood NN cord-024189-t7mbsr25 899 15 vessels vessel NNS cord-024189-t7mbsr25 899 16 , , , cord-024189-t7mbsr25 899 17 but but CC cord-024189-t7mbsr25 899 18 IgA IgA NNP cord-024189-t7mbsr25 899 19 is be VBZ cord-024189-t7mbsr25 899 20 not not RB cord-024189-t7mbsr25 899 21 the the DT cord-024189-t7mbsr25 899 22 predominant predominant JJ cord-024189-t7mbsr25 899 23 immunoreactant immunoreactant NN cord-024189-t7mbsr25 899 24 in in IN cord-024189-t7mbsr25 899 25 such such JJ cord-024189-t7mbsr25 899 26 cases case NNS cord-024189-t7mbsr25 899 27 . . . cord-024189-t7mbsr25 900 1 In in IN cord-024189-t7mbsr25 900 2 mild mild JJ cord-024189-t7mbsr25 900 3 cases case NNS cord-024189-t7mbsr25 900 4 of of IN cord-024189-t7mbsr25 900 5 HSP HSP NNP cord-024189-t7mbsr25 900 6 , , , cord-024189-t7mbsr25 900 7 no no DT cord-024189-t7mbsr25 900 8 specifi specifi NN cord-024189-t7mbsr25 900 9 c c NN cord-024189-t7mbsr25 900 10 therapy therapy NN cord-024189-t7mbsr25 900 11 is be VBZ cord-024189-t7mbsr25 900 12 necessary necessary JJ cord-024189-t7mbsr25 900 13 . . . cord-024189-t7mbsr25 901 1 Even even RB cord-024189-t7mbsr25 901 2 for for IN cord-024189-t7mbsr25 901 3 patients patient NNS cord-024189-t7mbsr25 901 4 with with IN cord-024189-t7mbsr25 901 5 glomerulonephritis glomerulonephritis NN cord-024189-t7mbsr25 901 6 , , , cord-024189-t7mbsr25 901 7 it -PRON- PRP cord-024189-t7mbsr25 901 8 has have VBZ cord-024189-t7mbsr25 901 9 been be VBN cord-024189-t7mbsr25 901 10 diffi diffi JJ cord-024189-t7mbsr25 901 11 cult cult NN cord-024189-t7mbsr25 901 12 to to TO cord-024189-t7mbsr25 901 13 demonstrate demonstrate VB cord-024189-t7mbsr25 901 14 that that DT cord-024189-t7mbsr25 901 15 treatment treatment NN cord-024189-t7mbsr25 901 16 with with IN cord-024189-t7mbsr25 901 17 glucocorticoids glucocorticoid NNS cord-024189-t7mbsr25 901 18 or or CC cord-024189-t7mbsr25 901 19 immunosuppressive immunosuppressive JJ cord-024189-t7mbsr25 901 20 agents agent NNS cord-024189-t7mbsr25 901 21 signifi signifi NNP cord-024189-t7mbsr25 901 22 cantly cantly NNP cord-024189-t7mbsr25 901 23 alters alter VBZ cord-024189-t7mbsr25 901 24 outcomes outcome NNS cord-024189-t7mbsr25 901 25 . . . cord-024189-t7mbsr25 902 1 Despite despite IN cord-024189-t7mbsr25 902 2 this this DT cord-024189-t7mbsr25 902 3 , , , cord-024189-t7mbsr25 902 4 it -PRON- PRP cord-024189-t7mbsr25 902 5 may may MD cord-024189-t7mbsr25 902 6 be be VB cord-024189-t7mbsr25 902 7 prudent prudent JJ cord-024189-t7mbsr25 902 8 to to TO cord-024189-t7mbsr25 902 9 treat treat VB cord-024189-t7mbsr25 902 10 aggressive aggressive JJ cord-024189-t7mbsr25 902 11 renal renal JJ cord-024189-t7mbsr25 902 12 involvement involvement NN cord-024189-t7mbsr25 902 13 with with IN cord-024189-t7mbsr25 902 14 an an DT cord-024189-t7mbsr25 902 15 immunosuppressive immunosuppressive JJ cord-024189-t7mbsr25 902 16 regimen regimen NN cord-024189-t7mbsr25 902 17 , , , cord-024189-t7mbsr25 902 18 including include VBG cord-024189-t7mbsr25 902 19 high high JJ cord-024189-t7mbsr25 902 20 - - HYPH cord-024189-t7mbsr25 902 21 dose dose NN cord-024189-t7mbsr25 902 22 glucocorticoids glucocorticoid NNS cord-024189-t7mbsr25 902 23 and and CC cord-024189-t7mbsr25 902 24 another another DT cord-024189-t7mbsr25 902 25 immunosuppressive immunosuppressive JJ cord-024189-t7mbsr25 902 26 agent agent NN cord-024189-t7mbsr25 902 27 such such JJ cord-024189-t7mbsr25 902 28 as as IN cord-024189-t7mbsr25 902 29 cyclophosphamide cyclophosphamide NN cord-024189-t7mbsr25 902 30 , , , cord-024189-t7mbsr25 902 31 azathioprine azathioprine NN cord-024189-t7mbsr25 902 32 , , , cord-024189-t7mbsr25 902 33 or or CC cord-024189-t7mbsr25 902 34 mycophenolate mycophenolate NNP cord-024189-t7mbsr25 902 35 mofetil mofetil NNP cord-024189-t7mbsr25 902 36 , , , cord-024189-t7mbsr25 902 37 depending depend VBG cord-024189-t7mbsr25 902 38 on on IN cord-024189-t7mbsr25 902 39 disease disease NN cord-024189-t7mbsr25 902 40 severity severity NN cord-024189-t7mbsr25 902 41 ( ( -LRB- cord-024189-t7mbsr25 902 42 8) 8) NN cord-024189-t7mbsr25 902 43 . . . cord-024189-t7mbsr25 903 1 In in IN cord-024189-t7mbsr25 903 2 patients patient NNS cord-024189-t7mbsr25 903 3 with with IN cord-024189-t7mbsr25 903 4 renal renal JJ cord-024189-t7mbsr25 903 5 involvement involvement NN cord-024189-t7mbsr25 903 6 , , , cord-024189-t7mbsr25 903 7 anecdotal anecdotal JJ cord-024189-t7mbsr25 903 8 evidence evidence NN cord-024189-t7mbsr25 903 9 suggests suggest VBZ cord-024189-t7mbsr25 903 10 that that IN cord-024189-t7mbsr25 903 11 plasmapheresis plasmapheresis NN cord-024189-t7mbsr25 903 12 and and CC cord-024189-t7mbsr25 903 13 intravenous intravenous JJ cord-024189-t7mbsr25 903 14 immunoglobulin immunoglobulin NN cord-024189-t7mbsr25 903 15 may may MD cord-024189-t7mbsr25 903 16 also also RB cord-024189-t7mbsr25 903 17 be be VB cord-024189-t7mbsr25 903 18 benefi benefi NNP cord-024189-t7mbsr25 903 19 cial cial NN cord-024189-t7mbsr25 903 20 , , , cord-024189-t7mbsr25 903 21 particularly particularly RB cord-024189-t7mbsr25 903 22 in in IN cord-024189-t7mbsr25 903 23 patients patient NNS cord-024189-t7mbsr25 903 24 who who WP cord-024189-t7mbsr25 903 25 are be VBP cord-024189-t7mbsr25 903 26 refractory refractory JJ cord-024189-t7mbsr25 903 27 to to IN cord-024189-t7mbsr25 903 28 standard standard JJ cord-024189-t7mbsr25 903 29 immunosuppressive immunosuppressive JJ cord-024189-t7mbsr25 903 30 regimens regimen NNS cord-024189-t7mbsr25 903 31 . . . cord-024189-t7mbsr25 904 1 Recurrences recurrence NNS cord-024189-t7mbsr25 904 2 of of IN cord-024189-t7mbsr25 904 3 skin skin NN cord-024189-t7mbsr25 904 4 disease disease NN cord-024189-t7mbsr25 904 5 , , , cord-024189-t7mbsr25 904 6 often often RB cord-024189-t7mbsr25 904 7 comprised comprise VBN cord-024189-t7mbsr25 904 8 of of IN cord-024189-t7mbsr25 904 9 multiple multiple JJ cord-024189-t7mbsr25 904 10 episodes episode NNS cord-024189-t7mbsr25 904 11 occurring occur VBG cord-024189-t7mbsr25 904 12 over over IN cord-024189-t7mbsr25 904 13 many many JJ cord-024189-t7mbsr25 904 14 months month NNS cord-024189-t7mbsr25 904 15 , , , cord-024189-t7mbsr25 904 16 are be VBP cord-024189-t7mbsr25 904 17 not not RB cord-024189-t7mbsr25 904 18 unusual unusual JJ cord-024189-t7mbsr25 904 19 . . . cord-024189-t7mbsr25 905 1 Generally generally RB cord-024189-t7mbsr25 905 2 , , , cord-024189-t7mbsr25 905 3 however however RB cord-024189-t7mbsr25 905 4 , , , cord-024189-t7mbsr25 905 5 even even RB cord-024189-t7mbsr25 905 6 in in IN cord-024189-t7mbsr25 905 7 patients patient NNS cord-024189-t7mbsr25 905 8 with with IN cord-024189-t7mbsr25 905 9 recurrent recurrent JJ cord-024189-t7mbsr25 905 10 disease disease NN cord-024189-t7mbsr25 905 11 , , , cord-024189-t7mbsr25 905 12 the the DT cord-024189-t7mbsr25 905 13 rule rule NN cord-024189-t7mbsr25 905 14 is be VBZ cord-024189-t7mbsr25 905 15 for for IN cord-024189-t7mbsr25 905 16 the the DT cord-024189-t7mbsr25 905 17 disorder disorder NN cord-024189-t7mbsr25 905 18 to to TO cord-024189-t7mbsr25 905 19 subside subside VB cord-024189-t7mbsr25 905 20 and and CC cord-024189-t7mbsr25 905 21 to to TO cord-024189-t7mbsr25 905 22 resolve resolve VB cord-024189-t7mbsr25 905 23 completely completely RB cord-024189-t7mbsr25 905 24 over over IN cord-024189-t7mbsr25 905 25 a a DT cord-024189-t7mbsr25 905 26 few few JJ cord-024189-t7mbsr25 905 27 months month NNS cord-024189-t7mbsr25 905 28 to to IN cord-024189-t7mbsr25 905 29 a a DT cord-024189-t7mbsr25 905 30 year year NN cord-024189-t7mbsr25 905 31 . . . cord-024189-t7mbsr25 906 1 In in IN cord-024189-t7mbsr25 906 2 a a DT cord-024189-t7mbsr25 906 3 minority minority NN cord-024189-t7mbsr25 906 4 of of IN cord-024189-t7mbsr25 906 5 patients patient NNS cord-024189-t7mbsr25 906 6 , , , cord-024189-t7mbsr25 906 7 some some DT cord-024189-t7mbsr25 906 8 evidence evidence NN cord-024189-t7mbsr25 906 9 of of IN cord-024189-t7mbsr25 906 10 permanent permanent JJ cord-024189-t7mbsr25 906 11 renal renal JJ cord-024189-t7mbsr25 906 12 damage damage NN cord-024189-t7mbsr25 906 13 persists persist VBZ cord-024189-t7mbsr25 906 14 in in IN cord-024189-t7mbsr25 906 15 the the DT cord-024189-t7mbsr25 906 16 form form NN cord-024189-t7mbsr25 906 17 of of IN cord-024189-t7mbsr25 906 18 proteinuria proteinuria NN cord-024189-t7mbsr25 906 19 and and CC cord-024189-t7mbsr25 906 20 hematuria hematuria NN cord-024189-t7mbsr25 906 21 . . . cord-024189-t7mbsr25 907 1 Only only RB cord-024189-t7mbsr25 907 2 a a DT cord-024189-t7mbsr25 907 3 small small JJ cord-024189-t7mbsr25 907 4 minority minority NN cord-024189-t7mbsr25 907 5 , , , cord-024189-t7mbsr25 907 6 probably probably RB cord-024189-t7mbsr25 907 7 well well RB cord-024189-t7mbsr25 907 8 under under IN cord-024189-t7mbsr25 907 9 5 5 CD cord-024189-t7mbsr25 907 10 % % NN cord-024189-t7mbsr25 907 11 , , , cord-024189-t7mbsr25 907 12 develop develop VB cord-024189-t7mbsr25 907 13 renal renal JJ cord-024189-t7mbsr25 907 14 failure failure NN cord-024189-t7mbsr25 907 15 as as IN cord-024189-t7mbsr25 907 16 a a DT cord-024189-t7mbsr25 907 17 result result NN cord-024189-t7mbsr25 907 18 of of IN cord-024189-t7mbsr25 907 19 HSP HSP NNP cord-024189-t7mbsr25 907 20 . . . cord-024189-t7mbsr25 908 1 The the DT cord-024189-t7mbsr25 908 2 study study NN cord-024189-t7mbsr25 908 3 of of IN cord-024189-t7mbsr25 908 4 urticaria urticaria NN cord-024189-t7mbsr25 908 5 is be VBZ cord-024189-t7mbsr25 908 6 hampered hamper VBN cord-024189-t7mbsr25 908 7 by by IN cord-024189-t7mbsr25 908 8 multiple multiple JJ cord-024189-t7mbsr25 908 9 terms term NNS cord-024189-t7mbsr25 908 10 that that WDT cord-024189-t7mbsr25 908 11 sound sound VBP cord-024189-t7mbsr25 908 12 similar similar JJ cord-024189-t7mbsr25 908 13 but but CC cord-024189-t7mbsr25 908 14 describe describe VBP cord-024189-t7mbsr25 908 15 different different JJ cord-024189-t7mbsr25 908 16 types type NNS cord-024189-t7mbsr25 908 17 of of IN cord-024189-t7mbsr25 908 18 diseases disease NNS cord-024189-t7mbsr25 908 19 . . . cord-024189-t7mbsr25 909 1 The the DT cord-024189-t7mbsr25 909 2 word word NN cord-024189-t7mbsr25 909 3 urticaria urticaria NN cord-024189-t7mbsr25 909 4 is be VBZ cord-024189-t7mbsr25 909 5 most most RBS cord-024189-t7mbsr25 909 6 frequently frequently RB cord-024189-t7mbsr25 909 7 used use VBN cord-024189-t7mbsr25 909 8 to to TO cord-024189-t7mbsr25 909 9 describe describe VB cord-024189-t7mbsr25 909 10 acute acute JJ cord-024189-t7mbsr25 909 11 urticaria urticaria NN cord-024189-t7mbsr25 909 12 , , , cord-024189-t7mbsr25 909 13 an an DT cord-024189-t7mbsr25 909 14 IgE ige NN cord-024189-t7mbsr25 909 15 - - HYPH cord-024189-t7mbsr25 909 16 mediated mediate VBN cord-024189-t7mbsr25 909 17 hypersensitivity hypersensitivity NN cord-024189-t7mbsr25 909 18 reaction reaction NN cord-024189-t7mbsr25 909 19 to to IN cord-024189-t7mbsr25 909 20 a a DT cord-024189-t7mbsr25 909 21 variety variety NN cord-024189-t7mbsr25 909 22 of of IN cord-024189-t7mbsr25 909 23 stimuli stimulus NNS cord-024189-t7mbsr25 909 24 , , , cord-024189-t7mbsr25 909 25 including include VBG cord-024189-t7mbsr25 909 26 medications medication NNS cord-024189-t7mbsr25 909 27 , , , cord-024189-t7mbsr25 909 28 infection infection NN cord-024189-t7mbsr25 909 29 , , , cord-024189-t7mbsr25 909 30 and and CC cord-024189-t7mbsr25 909 31 other other JJ cord-024189-t7mbsr25 909 32 triggers trigger NNS cord-024189-t7mbsr25 909 33 . . . cord-024189-t7mbsr25 910 1 Acute acute JJ cord-024189-t7mbsr25 910 2 urticaria urticaria NN cord-024189-t7mbsr25 910 3 manifests manifest VBZ cord-024189-t7mbsr25 910 4 as as IN cord-024189-t7mbsr25 910 5 pruritic pruritic JJ cord-024189-t7mbsr25 910 6 wheals wheal NNS cord-024189-t7mbsr25 910 7 that that WDT cord-024189-t7mbsr25 910 8 resolve resolve VBP cord-024189-t7mbsr25 910 9 days day NNS cord-024189-t7mbsr25 910 10 after after IN cord-024189-t7mbsr25 910 11 the the DT cord-024189-t7mbsr25 910 12 allergen allergen NN cord-024189-t7mbsr25 910 13 is be VBZ cord-024189-t7mbsr25 910 14 removed remove VBN cord-024189-t7mbsr25 910 15 . . . cord-024189-t7mbsr25 911 1 Chronic chronic JJ cord-024189-t7mbsr25 911 2 urticaria urticaria NN cord-024189-t7mbsr25 911 3 is be VBZ cord-024189-t7mbsr25 911 4 an an DT cord-024189-t7mbsr25 911 5 autoimmune autoimmune JJ cord-024189-t7mbsr25 911 6 condition condition NN cord-024189-t7mbsr25 911 7 that that WDT cord-024189-t7mbsr25 911 8 is be VBZ cord-024189-t7mbsr25 911 9 probably probably RB cord-024189-t7mbsr25 911 10 driven drive VBN cord-024189-t7mbsr25 911 11 by by IN cord-024189-t7mbsr25 911 12 an an DT cord-024189-t7mbsr25 911 13 autoantigen autoantigen NN cord-024189-t7mbsr25 911 14 . . . cord-024189-t7mbsr25 912 1 This this DT cord-024189-t7mbsr25 912 2 form form NN cord-024189-t7mbsr25 912 3 of of IN cord-024189-t7mbsr25 912 4 urticaria urticaria NN cord-024189-t7mbsr25 912 5 may may MD cord-024189-t7mbsr25 912 6 require require VB cord-024189-t7mbsr25 912 7 immunosuppressive immunosuppressive JJ cord-024189-t7mbsr25 912 8 therapy therapy NN cord-024189-t7mbsr25 912 9 in in IN cord-024189-t7mbsr25 912 10 addition addition NN cord-024189-t7mbsr25 912 11 to to IN cord-024189-t7mbsr25 912 12 antihistamines antihistamine NNS cord-024189-t7mbsr25 912 13 to to TO cord-024189-t7mbsr25 912 14 prevent prevent VB cord-024189-t7mbsr25 912 15 recurrence recurrence NN cord-024189-t7mbsr25 912 16 ( ( -LRB- cord-024189-t7mbsr25 912 17 9 9 CD cord-024189-t7mbsr25 912 18 ) ) -RRB- cord-024189-t7mbsr25 912 19 . . . cord-024189-t7mbsr25 913 1 Urticarial urticarial JJ cord-024189-t7mbsr25 913 2 vasculitis vasculitis NN cord-024189-t7mbsr25 913 3 describes describe VBZ cord-024189-t7mbsr25 913 4 a a DT cord-024189-t7mbsr25 913 5 form form NN cord-024189-t7mbsr25 913 6 of of IN cord-024189-t7mbsr25 913 7 small small JJ cord-024189-t7mbsr25 913 8 vessel vessel NN cord-024189-t7mbsr25 913 9 vasculitis vasculitis NN cord-024189-t7mbsr25 913 10 that that WDT cord-024189-t7mbsr25 913 11 is be VBZ cord-024189-t7mbsr25 913 12 characterized characterize VBN cord-024189-t7mbsr25 913 13 by by IN cord-024189-t7mbsr25 913 14 the the DT cord-024189-t7mbsr25 913 15 appearance appearance NN cord-024189-t7mbsr25 913 16 of of IN cord-024189-t7mbsr25 913 17 urticarial urticarial JJ cord-024189-t7mbsr25 913 18 wheals wheal NNS cord-024189-t7mbsr25 913 19 . . . cord-024189-t7mbsr25 914 1 Normocomplementemic normocomplementemic JJ cord-024189-t7mbsr25 914 2 urticarial urticarial JJ cord-024189-t7mbsr25 914 3 vasculitis vasculitis NN cord-024189-t7mbsr25 914 4 is be VBZ cord-024189-t7mbsr25 914 5 most most RBS cord-024189-t7mbsr25 914 6 often often RB cord-024189-t7mbsr25 914 7 simply simply RB cord-024189-t7mbsr25 914 8 an an DT cord-024189-t7mbsr25 914 9 example example NN cord-024189-t7mbsr25 914 10 of of IN cord-024189-t7mbsr25 914 11 hypersensitiv hypersensitiv JJ cord-024189-t7mbsr25 914 12 - - HYPH cord-024189-t7mbsr25 914 13 ity ity NN cord-024189-t7mbsr25 914 14 vasculitis vasculitis NN cord-024189-t7mbsr25 914 15 in in IN cord-024189-t7mbsr25 914 16 which which WDT cord-024189-t7mbsr25 914 17 the the DT cord-024189-t7mbsr25 914 18 principal principal JJ cord-024189-t7mbsr25 914 19 skin skin NN cord-024189-t7mbsr25 914 20 manifestation manifestation NN cord-024189-t7mbsr25 914 21 is be VBZ cord-024189-t7mbsr25 914 22 urticaria urticaria NN cord-024189-t7mbsr25 914 23 . . . cord-024189-t7mbsr25 915 1 Normocomplementemic normocomplementemic JJ cord-024189-t7mbsr25 915 2 urticarial urticarial JJ cord-024189-t7mbsr25 915 3 vasculitis vasculitis NN cord-024189-t7mbsr25 915 4 tends tend VBZ cord-024189-t7mbsr25 915 5 to to TO cord-024189-t7mbsr25 915 6 be be VB cord-024189-t7mbsr25 915 7 self self NN cord-024189-t7mbsr25 915 8 - - HYPH cord-024189-t7mbsr25 915 9 limited limit VBN cord-024189-t7mbsr25 915 10 , , , cord-024189-t7mbsr25 915 11 as as IN cord-024189-t7mbsr25 915 12 is be VBZ cord-024189-t7mbsr25 915 13 the the DT cord-024189-t7mbsr25 915 14 case case NN cord-024189-t7mbsr25 915 15 with with IN cord-024189-t7mbsr25 915 16 hypersensitivity hypersensitivity NN cord-024189-t7mbsr25 915 17 vasculitis vasculitis NN cord-024189-t7mbsr25 915 18 . . . cord-024189-t7mbsr25 916 1 In in IN cord-024189-t7mbsr25 916 2 contrast contrast NN cord-024189-t7mbsr25 916 3 , , , cord-024189-t7mbsr25 916 4 urticarial urticarial JJ cord-024189-t7mbsr25 916 5 vasculitis vasculitis NN cord-024189-t7mbsr25 916 6 associated associate VBN cord-024189-t7mbsr25 916 7 with with IN cord-024189-t7mbsr25 916 8 hypocomplementemia hypocomplementemia NNP cord-024189-t7mbsr25 916 9 is be VBZ cord-024189-t7mbsr25 916 10 much much RB cord-024189-t7mbsr25 916 11 more more RBR cord-024189-t7mbsr25 916 12 likely likely JJ cord-024189-t7mbsr25 916 13 to to TO cord-024189-t7mbsr25 916 14 constitute constitute VB cord-024189-t7mbsr25 916 15 a a DT cord-024189-t7mbsr25 916 16 signifi signifi NN cord-024189-t7mbsr25 916 17 ca can MD cord-024189-t7mbsr25 916 18 nt not RB cord-024189-t7mbsr25 916 19 and and CC cord-024189-t7mbsr25 916 20 persistent persistent JJ cord-024189-t7mbsr25 916 21 clinical clinical JJ cord-024189-t7mbsr25 916 22 problem problem NN cord-024189-t7mbsr25 916 23 . . . cord-024189-t7mbsr25 917 1 Two two CD cord-024189-t7mbsr25 917 2 categories category NNS cord-024189-t7mbsr25 917 3 of of IN cord-024189-t7mbsr25 917 4 urticarial urticarial JJ cord-024189-t7mbsr25 917 5 vasculitis vasculitis NN cord-024189-t7mbsr25 917 6 associated associate VBN cord-024189-t7mbsr25 917 7 with with IN cord-024189-t7mbsr25 917 8 hypocomplementemia hypocomplementemia NNP cord-024189-t7mbsr25 917 9 are be VBP cord-024189-t7mbsr25 917 10 recognized recognize VBN cord-024189-t7mbsr25 917 11 . . . cord-024189-t7mbsr25 918 1 The the DT cord-024189-t7mbsr25 918 2 distinctions distinction NNS cord-024189-t7mbsr25 918 3 between between IN cord-024189-t7mbsr25 918 4 these these DT cord-024189-t7mbsr25 918 5 two two CD cord-024189-t7mbsr25 918 6 categories category NNS cord-024189-t7mbsr25 918 7 are be VBP cord-024189-t7mbsr25 918 8 not not RB cord-024189-t7mbsr25 918 9 always always RB cord-024189-t7mbsr25 918 10 sharp sharp JJ cord-024189-t7mbsr25 918 11 , , , cord-024189-t7mbsr25 918 12 and and CC cord-024189-t7mbsr25 918 13 both both DT cord-024189-t7mbsr25 918 14 categories category NNS cord-024189-t7mbsr25 918 15 also also RB cord-024189-t7mbsr25 918 16 share share VBP cord-024189-t7mbsr25 918 17 a a DT cord-024189-t7mbsr25 918 18 number number NN cord-024189-t7mbsr25 918 19 of of IN cord-024189-t7mbsr25 918 20 features feature NNS cord-024189-t7mbsr25 918 21 with with IN cord-024189-t7mbsr25 918 22 systemic systemic JJ cord-024189-t7mbsr25 918 23 lupus lupus NN cord-024189-t7mbsr25 918 24 erythematosus erythematosus NN cord-024189-t7mbsr25 918 25 . . . cord-024189-t7mbsr25 919 1 The the DT cord-024189-t7mbsr25 919 2 fi fi NN cord-024189-t7mbsr25 919 3 rst rst NN cord-024189-t7mbsr25 919 4 category category NN cord-024189-t7mbsr25 919 5 , , , cord-024189-t7mbsr25 919 6 known know VBN cord-024189-t7mbsr25 919 7 simply simply RB cord-024189-t7mbsr25 919 8 as as IN cord-024189-t7mbsr25 919 9 hypocomplementemic hypocomplementemic JJ cord-024189-t7mbsr25 919 10 urticarial urticarial JJ cord-024189-t7mbsr25 919 11 vasculitis vasculitis NNP cord-024189-t7mbsr25 919 12 , , , cord-024189-t7mbsr25 919 13 refers refer VBZ cord-024189-t7mbsr25 919 14 to to IN cord-024189-t7mbsr25 919 15 cutaneous cutaneous JJ cord-024189-t7mbsr25 919 16 vasculitis vasculitis NN cord-024189-t7mbsr25 919 17 associated associate VBN cord-024189-t7mbsr25 919 18 with with IN cord-024189-t7mbsr25 919 19 low low JJ cord-024189-t7mbsr25 919 20 levels level NNS cord-024189-t7mbsr25 919 21 of of IN cord-024189-t7mbsr25 919 22 serum serum NN cord-024189-t7mbsr25 919 23 complement complement NN cord-024189-t7mbsr25 919 24 ( ( -LRB- cord-024189-t7mbsr25 919 25 C3 c3 NN cord-024189-t7mbsr25 919 26 and and CC cord-024189-t7mbsr25 919 27 C4 C4 NNP cord-024189-t7mbsr25 919 28 ) ) -RRB- cord-024189-t7mbsr25 919 29 . . . cord-024189-t7mbsr25 920 1 The the DT cord-024189-t7mbsr25 920 2 diagnosis diagnosis NN cord-024189-t7mbsr25 920 3 of of IN cord-024189-t7mbsr25 920 4 hypocomplementemic hypocomplementemic JJ cord-024189-t7mbsr25 920 5 urticarial urticarial JJ cord-024189-t7mbsr25 920 6 vasculitis vasculitis NNP cord-024189-t7mbsr25 920 7 is be VBZ cord-024189-t7mbsr25 920 8 predicated predicate VBN cord-024189-t7mbsr25 920 9 upon upon IN cord-024189-t7mbsr25 920 10 the the DT cord-024189-t7mbsr25 920 11 exclusion exclusion NN cord-024189-t7mbsr25 920 12 of of IN cord-024189-t7mbsr25 920 13 other other JJ cord-024189-t7mbsr25 920 14 disorders disorder NNS cord-024189-t7mbsr25 920 15 that that WDT cord-024189-t7mbsr25 920 16 may may MD cord-024189-t7mbsr25 920 17 present present VB cord-024189-t7mbsr25 920 18 in in IN cord-024189-t7mbsr25 920 19 a a DT cord-024189-t7mbsr25 920 20 similar similar JJ cord-024189-t7mbsr25 920 21 fashion fashion NN cord-024189-t7mbsr25 920 22 , , , cord-024189-t7mbsr25 920 23 particularly particularly RB cord-024189-t7mbsr25 920 24 cryoglobulinemia cryoglobulinemia NN cord-024189-t7mbsr25 920 25 and and CC cord-024189-t7mbsr25 920 26 SLE SLE NNP cord-024189-t7mbsr25 920 27 . . . cord-024189-t7mbsr25 921 1 The the DT cord-024189-t7mbsr25 921 2 second second JJ cord-024189-t7mbsr25 921 3 category category NN cord-024189-t7mbsr25 921 4 - - : cord-024189-t7mbsr25 921 5 a a DT cord-024189-t7mbsr25 921 6 more more RBR cord-024189-t7mbsr25 921 7 specifi specifi NN cord-024189-t7mbsr25 921 8 c c NN cord-024189-t7mbsr25 921 9 but but CC cord-024189-t7mbsr25 921 10 still still RB cord-024189-t7mbsr25 921 11 loosely loosely RB cord-024189-t7mbsr25 921 12 defi defi NNP cord-024189-t7mbsr25 921 13 ned ned NNP cord-024189-t7mbsr25 921 14 entity entity NN cord-024189-t7mbsr25 921 15 known know VBN cord-024189-t7mbsr25 921 16 as as IN cord-024189-t7mbsr25 921 17 the the DT cord-024189-t7mbsr25 921 18 hypocomplementemic hypocomplementemic JJ cord-024189-t7mbsr25 921 19 urticarial urticarial JJ cord-024189-t7mbsr25 921 20 vasculitis vasculitis NNP cord-024189-t7mbsr25 921 21 syndrome syndrome NN cord-024189-t7mbsr25 921 22 ( ( -LRB- cord-024189-t7mbsr25 921 23 HUVS)-consists huvs)-consists CD cord-024189-t7mbsr25 921 24 of of IN cord-024189-t7mbsr25 921 25 the the DT cord-024189-t7mbsr25 921 26 constellation constellation NN cord-024189-t7mbsr25 921 27 of of IN cord-024189-t7mbsr25 921 28 low low JJ cord-024189-t7mbsr25 921 29 complement complement NN cord-024189-t7mbsr25 921 30 levels level NNS cord-024189-t7mbsr25 921 31 and and CC cord-024189-t7mbsr25 921 32 urticaria urticaria NN cord-024189-t7mbsr25 921 33 for for IN cord-024189-t7mbsr25 921 34 a a DT cord-024189-t7mbsr25 921 35 period period NN cord-024189-t7mbsr25 921 36 of of IN cord-024189-t7mbsr25 921 37 at at RB cord-024189-t7mbsr25 921 38 least least RBS cord-024189-t7mbsr25 921 39 6 6 CD cord-024189-t7mbsr25 921 40 months month NNS cord-024189-t7mbsr25 921 41 , , , cord-024189-t7mbsr25 921 42 as as RB cord-024189-t7mbsr25 921 43 well well RB cord-024189-t7mbsr25 921 44 as as IN cord-024189-t7mbsr25 921 45 some some DT cord-024189-t7mbsr25 921 46 or or CC cord-024189-t7mbsr25 921 47 all all DT cord-024189-t7mbsr25 921 48 of of IN cord-024189-t7mbsr25 921 49 the the DT cord-024189-t7mbsr25 921 50 following follow VBG cord-024189-t7mbsr25 921 51 : : : cord-024189-t7mbsr25 921 52 arthritis arthritis NN cord-024189-t7mbsr25 921 53 , , , cord-024189-t7mbsr25 921 54 glomerulonephritis glomerulonephritis NN cord-024189-t7mbsr25 921 55 , , , cord-024189-t7mbsr25 921 56 uveitis uveitis NN cord-024189-t7mbsr25 921 57 , , , cord-024189-t7mbsr25 921 58 angioedema angioedema NN cord-024189-t7mbsr25 921 59 , , , cord-024189-t7mbsr25 921 60 chronic chronic JJ cord-024189-t7mbsr25 921 61 obstructive obstructive JJ cord-024189-t7mbsr25 921 62 pulmonary pulmonary JJ cord-024189-t7mbsr25 921 63 disease disease NN cord-024189-t7mbsr25 921 64 , , , cord-024189-t7mbsr25 921 65 pleurisy pleurisy NN cord-024189-t7mbsr25 921 66 , , , cord-024189-t7mbsr25 921 67 or or CC cord-024189-t7mbsr25 921 68 pericarditis pericarditis NN cord-024189-t7mbsr25 921 69 . . . cord-024189-t7mbsr25 922 1 Although although IN cord-024189-t7mbsr25 922 2 the the DT cord-024189-t7mbsr25 922 3 lesions lesion NNS cord-024189-t7mbsr25 922 4 associated associate VBN cord-024189-t7mbsr25 922 5 with with IN cord-024189-t7mbsr25 922 6 chronic chronic JJ cord-024189-t7mbsr25 922 7 urticaria urticaria NN cord-024189-t7mbsr25 922 8 and and CC cord-024189-t7mbsr25 922 9 urticarial urticarial JJ cord-024189-t7mbsr25 922 10 vasculitis vasculitis NN cord-024189-t7mbsr25 922 11 are be VBP cord-024189-t7mbsr25 922 12 similar similar JJ cord-024189-t7mbsr25 922 13 in in IN cord-024189-t7mbsr25 922 14 appearance appearance NN cord-024189-t7mbsr25 922 15 , , , cord-024189-t7mbsr25 922 16 certain certain JJ cord-024189-t7mbsr25 922 17 differences difference NNS cord-024189-t7mbsr25 922 18 help help VBP cord-024189-t7mbsr25 922 19 differentiate differentiate VB cord-024189-t7mbsr25 922 20 these these DT cord-024189-t7mbsr25 922 21 two two CD cord-024189-t7mbsr25 922 22 conditions condition NNS cord-024189-t7mbsr25 922 23 . . . cord-024189-t7mbsr25 923 1 In in IN cord-024189-t7mbsr25 923 2 urticarial urticarial JJ cord-024189-t7mbsr25 923 3 vasculitis vasculitis NN cord-024189-t7mbsr25 923 4 , , , cord-024189-t7mbsr25 923 5 the the DT cord-024189-t7mbsr25 923 6 urticaria urticaria NN cord-024189-t7mbsr25 923 7 typically typically RB cord-024189-t7mbsr25 923 8 have have VBP cord-024189-t7mbsr25 923 9 a a DT cord-024189-t7mbsr25 923 10 purpuric purpuric JJ cord-024189-t7mbsr25 923 11 quality quality NN cord-024189-t7mbsr25 923 12 , , , cord-024189-t7mbsr25 923 13 indicative indicative JJ cord-024189-t7mbsr25 923 14 of of IN cord-024189-t7mbsr25 923 15 small small JJ cord-024189-t7mbsr25 923 16 blood blood NN cord-024189-t7mbsr25 923 17 vessel vessel NN cord-024189-t7mbsr25 923 18 damage damage NN cord-024189-t7mbsr25 923 19 and and CC cord-024189-t7mbsr25 923 20 red red JJ cord-024189-t7mbsr25 923 21 blood blood NN cord-024189-t7mbsr25 923 22 cell cell NN cord-024189-t7mbsr25 923 23 extravasation extravasation NN cord-024189-t7mbsr25 923 24 ( ( -LRB- cord-024189-t7mbsr25 923 25 Figure figure NN cord-024189-t7mbsr25 923 26 21D-4 21d-4 CD cord-024189-t7mbsr25 923 27 ) ) -RRB- cord-024189-t7mbsr25 923 28 . . . cord-024189-t7mbsr25 924 1 Unlike unlike IN cord-024189-t7mbsr25 924 2 common common JJ cord-024189-t7mbsr25 924 3 urticaria urticaria NN cord-024189-t7mbsr25 924 4 , , , cord-024189-t7mbsr25 924 5 the the DT cord-024189-t7mbsr25 924 6 lesions lesion NNS cord-024189-t7mbsr25 924 7 of of IN cord-024189-t7mbsr25 924 8 urticarial urticarial JJ cord-024189-t7mbsr25 924 9 vasculitis vasculitis NN cord-024189-t7mbsr25 924 10 are be VBP cord-024189-t7mbsr25 924 11 frequently frequently RB cord-024189-t7mbsr25 924 12 associated associate VBN cord-024189-t7mbsr25 924 13 with with IN cord-024189-t7mbsr25 924 14 moderate moderate JJ cord-024189-t7mbsr25 924 15 pain pain NN cord-024189-t7mbsr25 924 16 , , , cord-024189-t7mbsr25 924 17 burning burning NN cord-024189-t7mbsr25 924 18 , , , cord-024189-t7mbsr25 924 19 and and CC cord-024189-t7mbsr25 924 20 tenderness tenderness NN cord-024189-t7mbsr25 924 21 , , , cord-024189-t7mbsr25 924 22 in in IN cord-024189-t7mbsr25 924 23 addition addition NN cord-024189-t7mbsr25 924 24 to to IN cord-024189-t7mbsr25 924 25 pruritus pruritus NN cord-024189-t7mbsr25 924 26 . . . cord-024189-t7mbsr25 925 1 Whereas whereas IN cord-024189-t7mbsr25 925 2 common common JJ cord-024189-t7mbsr25 925 3 urticaria urticaria NN cord-024189-t7mbsr25 925 4 typically typically RB cord-024189-t7mbsr25 925 5 resolve resolve VBP cord-024189-t7mbsr25 925 6 completely completely RB cord-024189-t7mbsr25 925 7 within within IN cord-024189-t7mbsr25 925 8 24 24 CD cord-024189-t7mbsr25 925 9 to to TO cord-024189-t7mbsr25 925 10 48 48 CD cord-024189-t7mbsr25 925 11 hours hour NNS cord-024189-t7mbsr25 925 12 , , , cord-024189-t7mbsr25 925 13 the the DT cord-024189-t7mbsr25 925 14 lesions lesion NNS cord-024189-t7mbsr25 925 15 of of IN cord-024189-t7mbsr25 925 16 urticarial urticarial JJ cord-024189-t7mbsr25 925 17 vasculitis vasculitis NN cord-024189-t7mbsr25 925 18 may may MD cord-024189-t7mbsr25 925 19 take take VB cord-024189-t7mbsr25 925 20 days day NNS cord-024189-t7mbsr25 925 21 to to TO cord-024189-t7mbsr25 925 22 resolve resolve VB cord-024189-t7mbsr25 925 23 completely completely RB cord-024189-t7mbsr25 925 24 and and CC cord-024189-t7mbsr25 925 25 often often RB cord-024189-t7mbsr25 925 26 worsen worsen VBP cord-024189-t7mbsr25 925 27 without without IN cord-024189-t7mbsr25 925 28 therapy therapy NN cord-024189-t7mbsr25 925 29 . . . cord-024189-t7mbsr25 926 1 Arthralgias Arthralgias NNP cord-024189-t7mbsr25 926 2 and and CC cord-024189-t7mbsr25 926 3 myalgias myalgias NNP cord-024189-t7mbsr25 926 4 are be VBP cord-024189-t7mbsr25 926 5 common common JJ cord-024189-t7mbsr25 926 6 in in IN cord-024189-t7mbsr25 926 7 urticarial urticarial JJ cord-024189-t7mbsr25 926 8 vasculitis vasculitis NN cord-024189-t7mbsr25 926 9 . . . cord-024189-t7mbsr25 927 1 As as IN cord-024189-t7mbsr25 927 2 noted note VBN cord-024189-t7mbsr25 927 3 above above RB cord-024189-t7mbsr25 927 4 , , , cord-024189-t7mbsr25 927 5 patients patient NNS cord-024189-t7mbsr25 927 6 with with IN cord-024189-t7mbsr25 927 7 HUVS HUVS NNP cord-024189-t7mbsr25 927 8 may may MD cord-024189-t7mbsr25 927 9 also also RB cord-024189-t7mbsr25 927 10 develop develop VB cord-024189-t7mbsr25 927 11 glomerulonephritis glomerulonephritis NN cord-024189-t7mbsr25 927 12 , , , cord-024189-t7mbsr25 927 13 pulmonary pulmonary JJ cord-024189-t7mbsr25 927 14 manifestations manifestation NNS cord-024189-t7mbsr25 927 15 ( ( -LRB- cord-024189-t7mbsr25 927 16 particularly particularly RB cord-024189-t7mbsr25 927 17 obstructive obstructive JJ cord-024189-t7mbsr25 927 18 airway airway NN cord-024189-t7mbsr25 927 19 disease disease NN cord-024189-t7mbsr25 927 20 ) ) -RRB- cord-024189-t7mbsr25 927 21 , , , cord-024189-t7mbsr25 927 22 and and CC cord-024189-t7mbsr25 927 23 other other JJ cord-024189-t7mbsr25 927 24 fi fi NN cord-024189-t7mbsr25 927 25 ndings nding NNS cord-024189-t7mbsr25 927 26 . . . cord-024189-t7mbsr25 928 1 Gastrointestinal gastrointestinal JJ cord-024189-t7mbsr25 928 2 , , , cord-024189-t7mbsr25 928 3 cardiovascular cardiovascular JJ cord-024189-t7mbsr25 928 4 , , , cord-024189-t7mbsr25 928 5 and and CC cord-024189-t7mbsr25 928 6 neurologic neurologic JJ cord-024189-t7mbsr25 928 7 manifestations manifestation NNS cord-024189-t7mbsr25 928 8 are be VBP cord-024189-t7mbsr25 928 9 uncommon uncommon JJ cord-024189-t7mbsr25 928 10 , , , cord-024189-t7mbsr25 928 11 but but CC cord-024189-t7mbsr25 928 12 have have VBP cord-024189-t7mbsr25 928 13 been be VBN cord-024189-t7mbsr25 928 14 reported report VBN cord-024189-t7mbsr25 928 15 . . . cord-024189-t7mbsr25 929 1 There there EX cord-024189-t7mbsr25 929 2 is be VBZ cord-024189-t7mbsr25 929 3 striking strike VBG cord-024189-t7mbsr25 929 4 overlap overlap NN cord-024189-t7mbsr25 929 5 between between IN cord-024189-t7mbsr25 929 6 HUVS HUVS NNP cord-024189-t7mbsr25 929 7 and and CC cord-024189-t7mbsr25 929 8 SLE SLE NNP cord-024189-t7mbsr25 929 9 , , , cord-024189-t7mbsr25 929 10 and and CC cord-024189-t7mbsr25 929 11 patients patient NNS cord-024189-t7mbsr25 929 12 will will MD cord-024189-t7mbsr25 929 13 frequently frequently RB cord-024189-t7mbsr25 929 14 have have VB cord-024189-t7mbsr25 929 15 characteristics characteristic NNS cord-024189-t7mbsr25 929 16 of of IN cord-024189-t7mbsr25 929 17 both both DT cord-024189-t7mbsr25 929 18 , , , cord-024189-t7mbsr25 929 19 although although IN cord-024189-t7mbsr25 929 20 angioedema angioedema NN cord-024189-t7mbsr25 929 21 and and CC cord-024189-t7mbsr25 929 22 COPD COPD NNP cord-024189-t7mbsr25 929 23 are be VBP cord-024189-t7mbsr25 929 24 more more RBR cord-024189-t7mbsr25 929 25 common common JJ cord-024189-t7mbsr25 929 26 in in IN cord-024189-t7mbsr25 929 27 HUVS HUVS NNP cord-024189-t7mbsr25 929 28 . . . cord-024189-t7mbsr25 930 1 Biopsy biopsy NN cord-024189-t7mbsr25 930 2 of of IN cord-024189-t7mbsr25 930 3 an an DT cord-024189-t7mbsr25 930 4 urticarial urticarial JJ cord-024189-t7mbsr25 930 5 wheal wheal NN cord-024189-t7mbsr25 930 6 in in IN cord-024189-t7mbsr25 930 7 UV UV NNP cord-024189-t7mbsr25 930 8 will will MD cord-024189-t7mbsr25 930 9 demonstrate demonstrate VB cord-024189-t7mbsr25 930 10 evidence evidence NN cord-024189-t7mbsr25 930 11 of of IN cord-024189-t7mbsr25 930 12 leukocytoclastic leukocytoclastic JJ cord-024189-t7mbsr25 930 13 vasculitis vasculitis NN cord-024189-t7mbsr25 930 14 , , , cord-024189-t7mbsr25 930 15 including include VBG cord-024189-t7mbsr25 930 16 injury injury NN cord-024189-t7mbsr25 930 17 to to IN cord-024189-t7mbsr25 930 18 the the DT cord-024189-t7mbsr25 930 19 endothelial endothelial JJ cord-024189-t7mbsr25 930 20 cells cell NNS cord-024189-t7mbsr25 930 21 of of IN cord-024189-t7mbsr25 930 22 the the DT cord-024189-t7mbsr25 930 23 postcapillary postcapillary JJ cord-024189-t7mbsr25 930 24 venules venule NNS cord-024189-t7mbsr25 930 25 , , , cord-024189-t7mbsr25 930 26 erythrocyte erythrocyte NN cord-024189-t7mbsr25 930 27 extravasation extravasation NN cord-024189-t7mbsr25 930 28 , , , cord-024189-t7mbsr25 930 29 leukocytoclasis leukocytoclasis NNP cord-024189-t7mbsr25 930 30 , , , cord-024189-t7mbsr25 930 31 fi fi NNP cord-024189-t7mbsr25 930 32 brin brin NNP cord-024189-t7mbsr25 930 33 deposition deposition NN cord-024189-t7mbsr25 930 34 , , , cord-024189-t7mbsr25 930 35 and and CC cord-024189-t7mbsr25 930 36 a a DT cord-024189-t7mbsr25 930 37 perivascular perivascular JJ cord-024189-t7mbsr25 930 38 neutrophilic neutrophilic NN cord-024189-t7mbsr25 930 39 ( ( -LRB- cord-024189-t7mbsr25 930 40 or or CC cord-024189-t7mbsr25 930 41 less less RBR cord-024189-t7mbsr25 930 42 commonly commonly RB cord-024189-t7mbsr25 930 43 , , , cord-024189-t7mbsr25 930 44 lymphocytic lymphocytic JJ cord-024189-t7mbsr25 930 45 ) ) -RRB- cord-024189-t7mbsr25 930 46 infi infi NNP cord-024189-t7mbsr25 930 47 ltrate ltrate NNP cord-024189-t7mbsr25 930 48 . . . cord-024189-t7mbsr25 931 1 Direct direct JJ cord-024189-t7mbsr25 931 2 immunofl immunofl NN cord-024189-t7mbsr25 931 3 uorescence uorescence NN cord-024189-t7mbsr25 931 4 demonstrates demonstrate VBZ cord-024189-t7mbsr25 931 5 immune immune JJ cord-024189-t7mbsr25 931 6 complex complex JJ cord-024189-t7mbsr25 931 7 deposition deposition NN cord-024189-t7mbsr25 931 8 around around IN cord-024189-t7mbsr25 931 9 blood blood NN cord-024189-t7mbsr25 931 10 vessels vessel NNS cord-024189-t7mbsr25 931 11 in in IN cord-024189-t7mbsr25 931 12 the the DT cord-024189-t7mbsr25 931 13 superfi superfi NNS cord-024189-t7mbsr25 931 14 cial cial JJ cord-024189-t7mbsr25 931 15 dermis dermis NN cord-024189-t7mbsr25 931 16 and and CC cord-024189-t7mbsr25 931 17 striking strike VBG cord-024189-t7mbsr25 931 18 deposition deposition NN cord-024189-t7mbsr25 931 19 of of IN cord-024189-t7mbsr25 931 20 immunoglobulins immunoglobulin NNS cord-024189-t7mbsr25 931 21 and and CC cord-024189-t7mbsr25 931 22 complement complement VB cord-024189-t7mbsr25 931 23 along along IN cord-024189-t7mbsr25 931 24 the the DT cord-024189-t7mbsr25 931 25 dermal dermal JJ cord-024189-t7mbsr25 931 26 - - HYPH cord-024189-t7mbsr25 931 27 epidermal epidermal JJ cord-024189-t7mbsr25 931 28 junction junction NN cord-024189-t7mbsr25 931 29 ( ( -LRB- cord-024189-t7mbsr25 931 30 Figure figure NN cord-024189-t7mbsr25 931 31 21D-5 21d-5 CD cord-024189-t7mbsr25 931 32 ) ) -RRB- cord-024189-t7mbsr25 931 33 . . . cord-024189-t7mbsr25 932 1 The the DT cord-024189-t7mbsr25 932 2 " " `` cord-024189-t7mbsr25 932 3 interface interface NN cord-024189-t7mbsr25 932 4 dermatitis dermatitis NN cord-024189-t7mbsr25 932 5 " " '' cord-024189-t7mbsr25 932 6 is be VBZ cord-024189-t7mbsr25 932 7 identical identical JJ cord-024189-t7mbsr25 932 8 to to IN cord-024189-t7mbsr25 932 9 that that DT cord-024189-t7mbsr25 932 10 observed observe VBN cord-024189-t7mbsr25 932 11 in in IN cord-024189-t7mbsr25 932 12 lupus- lupus- NN cord-024189-t7mbsr25 933 1 a a DT cord-024189-t7mbsr25 933 2 histopathological histopathological FW cord-024189-t7mbsr25 933 3 fi fi NNP cord-024189-t7mbsr25 933 4 nding nding NN cord-024189-t7mbsr25 933 5 termed term VBD cord-024189-t7mbsr25 933 6 the the DT cord-024189-t7mbsr25 933 7 lupus lupus NNP cord-024189-t7mbsr25 933 8 band band NN cord-024189-t7mbsr25 933 9 test test NN cord-024189-t7mbsr25 933 10 . . . cord-024189-t7mbsr25 934 1 In in IN cord-024189-t7mbsr25 934 2 the the DT cord-024189-t7mbsr25 934 3 proper proper JJ cord-024189-t7mbsr25 934 4 setting setting NN cord-024189-t7mbsr25 934 5 , , , cord-024189-t7mbsr25 934 6 these these DT cord-024189-t7mbsr25 934 7 fi fi NNP cord-024189-t7mbsr25 934 8 ndings nding NNS cord-024189-t7mbsr25 934 9 ( ( -LRB- cord-024189-t7mbsr25 934 10 interface interface NN cord-024189-t7mbsr25 934 11 dermatitis dermatitis NN cord-024189-t7mbsr25 934 12 as as RB cord-024189-t7mbsr25 934 13 well well RB cord-024189-t7mbsr25 934 14 as as IN cord-024189-t7mbsr25 934 15 immunoreactant immunoreactant JJ cord-024189-t7mbsr25 934 16 deposition deposition NN cord-024189-t7mbsr25 934 17 within within IN cord-024189-t7mbsr25 934 18 blood blood NN cord-024189-t7mbsr25 934 19 vessels vessel NNS cord-024189-t7mbsr25 934 20 ) ) -RRB- cord-024189-t7mbsr25 934 21 are be VBP cord-024189-t7mbsr25 934 22 diagnostic diagnostic JJ cord-024189-t7mbsr25 934 23 of of IN cord-024189-t7mbsr25 934 24 hypocomplementemic hypocomplementemic JJ cord-024189-t7mbsr25 934 25 urticarial urticarial JJ cord-024189-t7mbsr25 934 26 vasculitis vasculitis NNP cord-024189-t7mbsr25 934 27 . . . cord-024189-t7mbsr25 935 1 HUVS HUVS NNP cord-024189-t7mbsr25 935 2 , , , cord-024189-t7mbsr25 935 3 in in IN cord-024189-t7mbsr25 935 4 contrast contrast NN cord-024189-t7mbsr25 935 5 , , , cord-024189-t7mbsr25 935 6 is be VBZ cord-024189-t7mbsr25 935 7 a a DT cord-024189-t7mbsr25 935 8 clinical clinical JJ cord-024189-t7mbsr25 935 9 diag diag NN cord-024189-t7mbsr25 935 10 - - HYPH cord-024189-t7mbsr25 935 11 nosis nosis NN cord-024189-t7mbsr25 935 12 based base VBN cord-024189-t7mbsr25 935 13 not not RB cord-024189-t7mbsr25 935 14 only only RB cord-024189-t7mbsr25 935 15 on on IN cord-024189-t7mbsr25 935 16 the the DT cord-024189-t7mbsr25 935 17 presence presence NN cord-024189-t7mbsr25 935 18 of of IN cord-024189-t7mbsr25 935 19 urticarial urticarial JJ cord-024189-t7mbsr25 935 20 vasculitis vasculitis NN cord-024189-t7mbsr25 935 21 but but CC cord-024189-t7mbsr25 935 22 also also RB cord-024189-t7mbsr25 935 23 the the DT cord-024189-t7mbsr25 935 24 occurrence occurrence NN cord-024189-t7mbsr25 935 25 of of IN cord-024189-t7mbsr25 935 26 typical typical JJ cord-024189-t7mbsr25 935 27 features feature NNS cord-024189-t7mbsr25 935 28 in in IN cord-024189-t7mbsr25 935 29 extracutaneous extracutaneous JJ cord-024189-t7mbsr25 935 30 organ organ NN cord-024189-t7mbsr25 935 31 systems system NNS cord-024189-t7mbsr25 935 32 . . . cord-024189-t7mbsr25 936 1 Some some DT cord-024189-t7mbsr25 936 2 cases case NNS cord-024189-t7mbsr25 936 3 of of IN cord-024189-t7mbsr25 936 4 hypocomplementemic hypocomplementemic JJ cord-024189-t7mbsr25 936 5 urticarial urticarial JJ cord-024189-t7mbsr25 936 6 vasculitis vasculitis NN cord-024189-t7mbsr25 936 7 respond respond VBP cord-024189-t7mbsr25 936 8 to to IN cord-024189-t7mbsr25 936 9 therapies therapy NNS cord-024189-t7mbsr25 936 10 commonly commonly RB cord-024189-t7mbsr25 936 11 used use VBN cord-024189-t7mbsr25 936 12 for for IN cord-024189-t7mbsr25 936 13 the the DT cord-024189-t7mbsr25 936 14 treatment treatment NN cord-024189-t7mbsr25 936 15 of of IN cord-024189-t7mbsr25 936 16 SLE SLE NNP cord-024189-t7mbsr25 936 17 , , , cord-024189-t7mbsr25 936 18 including include VBG cord-024189-t7mbsr25 936 19 low low JJ cord-024189-t7mbsr25 936 20 - - HYPH cord-024189-t7mbsr25 936 21 dose dose NN cord-024189-t7mbsr25 936 22 prednisone prednisone NN cord-024189-t7mbsr25 936 23 , , , cord-024189-t7mbsr25 936 24 hydroxychloroquine hydroxychloroquine NNP cord-024189-t7mbsr25 936 25 , , , cord-024189-t7mbsr25 936 26 dapsone dapsone NNP cord-024189-t7mbsr25 936 27 , , , cord-024189-t7mbsr25 936 28 or or CC cord-024189-t7mbsr25 936 29 other other JJ cord-024189-t7mbsr25 936 30 immunomodulatory immunomodulatory JJ cord-024189-t7mbsr25 936 31 agents agent NNS cord-024189-t7mbsr25 936 32 . . . cord-024189-t7mbsr25 937 1 There there EX cord-024189-t7mbsr25 937 2 is be VBZ cord-024189-t7mbsr25 937 3 anecdotal anecdotal JJ cord-024189-t7mbsr25 937 4 evidence evidence NN cord-024189-t7mbsr25 937 5 that that IN cord-024189-t7mbsr25 937 6 antihistamines antihistamine NNS cord-024189-t7mbsr25 937 7 , , , cord-024189-t7mbsr25 937 8 calcium calcium NN cord-024189-t7mbsr25 937 9 channel channel NN cord-024189-t7mbsr25 937 10 antagonists antagonist NNS cord-024189-t7mbsr25 937 11 , , , cord-024189-t7mbsr25 937 12 doxepin doxepin NN cord-024189-t7mbsr25 937 13 , , , cord-024189-t7mbsr25 937 14 methotrexate methotrexate NNP cord-024189-t7mbsr25 937 15 , , , cord-024189-t7mbsr25 937 16 indomethacin indomethacin NN cord-024189-t7mbsr25 937 17 , , , cord-024189-t7mbsr25 937 18 colchicine colchicine NNP cord-024189-t7mbsr25 937 19 , , , cord-024189-t7mbsr25 937 20 and and CC cord-024189-t7mbsr25 937 21 pentoxifylline pentoxifylline NNP cord-024189-t7mbsr25 937 22 are be VBP cord-024189-t7mbsr25 937 23 effective effective JJ cord-024189-t7mbsr25 937 24 in in IN cord-024189-t7mbsr25 937 25 some some DT cord-024189-t7mbsr25 937 26 cases case NNS cord-024189-t7mbsr25 937 27 . . . cord-024189-t7mbsr25 938 1 Serious serious JJ cord-024189-t7mbsr25 938 2 cases case NNS cord-024189-t7mbsr25 938 3 , , , cord-024189-t7mbsr25 938 4 particularly particularly RB cord-024189-t7mbsr25 938 5 those those DT cord-024189-t7mbsr25 938 6 presenting present VBG cord-024189-t7mbsr25 938 7 with with IN cord-024189-t7mbsr25 938 8 glomerulonephritis glomerulonephritis NN cord-024189-t7mbsr25 938 9 or or CC cord-024189-t7mbsr25 938 10 other other JJ cord-024189-t7mbsr25 938 11 forms form NNS cord-024189-t7mbsr25 938 12 of of IN cord-024189-t7mbsr25 938 13 serious serious JJ cord-024189-t7mbsr25 938 14 organ organ NN cord-024189-t7mbsr25 938 15 involvement involvement NN cord-024189-t7mbsr25 938 16 , , , cord-024189-t7mbsr25 938 17 may may MD cord-024189-t7mbsr25 938 18 require require VB cord-024189-t7mbsr25 938 19 treatment treatment NN cord-024189-t7mbsr25 938 20 with with IN cord-024189-t7mbsr25 938 21 high high JJ cord-024189-t7mbsr25 938 22 doses dose NNS cord-024189-t7mbsr25 938 23 of of IN cord-024189-t7mbsr25 938 24 glucocorticoids glucocorticoid NNS cord-024189-t7mbsr25 938 25 and and CC cord-024189-t7mbsr25 938 26 cytotoxic cytotoxic JJ cord-024189-t7mbsr25 938 27 agents agent NNS cord-024189-t7mbsr25 938 28 . . . cord-024189-t7mbsr25 939 1 Both both DT cord-024189-t7mbsr25 939 2 chronic chronic JJ cord-024189-t7mbsr25 939 3 obstructive obstructive JJ cord-024189-t7mbsr25 939 4 pulmonary pulmonary JJ cord-024189-t7mbsr25 939 5 disease disease NN cord-024189-t7mbsr25 939 6 ( ( -LRB- cord-024189-t7mbsr25 939 7 COPD COPD NNP cord-024189-t7mbsr25 939 8 ) ) -RRB- cord-024189-t7mbsr25 939 9 and and CC cord-024189-t7mbsr25 939 10 cardiac cardiac JJ cord-024189-t7mbsr25 939 11 valvular valvular JJ cord-024189-t7mbsr25 939 12 abnormalities abnormality NNS cord-024189-t7mbsr25 939 13 are be VBP cord-024189-t7mbsr25 939 14 associated associate VBN cord-024189-t7mbsr25 939 15 with with IN cord-024189-t7mbsr25 939 16 HUVS HUVS NNP cord-024189-t7mbsr25 939 17 , , , cord-024189-t7mbsr25 939 18 and and CC cord-024189-t7mbsr25 939 19 may may MD cord-024189-t7mbsr25 939 20 require require VB cord-024189-t7mbsr25 939 21 specifi specifi NNP cord-024189-t7mbsr25 939 22 c c NN cord-024189-t7mbsr25 939 23 treatment treatment NN cord-024189-t7mbsr25 939 24 as as RB cord-024189-t7mbsr25 939 25 well well RB cord-024189-t7mbsr25 939 26 . . . cord-024189-t7mbsr25 940 1 The the DT cord-024189-t7mbsr25 940 2 prognosis prognosis NN cord-024189-t7mbsr25 940 3 of of IN cord-024189-t7mbsr25 940 4 HUVS HUVS NNP cord-024189-t7mbsr25 940 5 is be VBZ cord-024189-t7mbsr25 940 6 frequently frequently RB cord-024189-t7mbsr25 940 7 linked link VBN cord-024189-t7mbsr25 940 8 to to IN cord-024189-t7mbsr25 940 9 the the DT cord-024189-t7mbsr25 940 10 disorder disorder NN cord-024189-t7mbsr25 940 11 with with IN cord-024189-t7mbsr25 940 12 which which WDT cord-024189-t7mbsr25 940 13 it -PRON- PRP cord-024189-t7mbsr25 940 14 is be VBZ cord-024189-t7mbsr25 940 15 associated associate VBN cord-024189-t7mbsr25 940 16 . . . cord-024189-t7mbsr25 941 1 SLE SLE NNP cord-024189-t7mbsr25 941 2 , , , cord-024189-t7mbsr25 941 3 COPD COPD NNP cord-024189-t7mbsr25 941 4 , , , cord-024189-t7mbsr25 941 5 angioedema angioedema NN cord-024189-t7mbsr25 941 6 , , , cord-024189-t7mbsr25 941 7 and and CC cord-024189-t7mbsr25 941 8 valvular valvular JJ cord-024189-t7mbsr25 941 9 abnormalities abnormality NNS cord-024189-t7mbsr25 941 10 are be VBP cord-024189-t7mbsr25 941 11 all all RB cord-024189-t7mbsr25 941 12 known know VBN cord-024189-t7mbsr25 941 13 to to TO cord-024189-t7mbsr25 941 14 occur occur VB cord-024189-t7mbsr25 941 15 in in IN cord-024189-t7mbsr25 941 16 association association NN cord-024189-t7mbsr25 941 17 with with IN cord-024189-t7mbsr25 941 18 this this DT cord-024189-t7mbsr25 941 19 disorder disorder NN cord-024189-t7mbsr25 941 20 , , , cord-024189-t7mbsr25 941 21 and and CC cord-024189-t7mbsr25 941 22 in in IN cord-024189-t7mbsr25 941 23 such such JJ cord-024189-t7mbsr25 941 24 cases case NNS cord-024189-t7mbsr25 941 25 , , , cord-024189-t7mbsr25 941 26 may may MD cord-024189-t7mbsr25 941 27 strongly strongly RB cord-024189-t7mbsr25 941 28 infl infl VB cord-024189-t7mbsr25 941 29 uence uence NN cord-024189-t7mbsr25 941 30 both both CC cord-024189-t7mbsr25 941 31 quality quality NN cord-024189-t7mbsr25 941 32 and and CC cord-024189-t7mbsr25 941 33 quantity quantity NN cord-024189-t7mbsr25 941 34 of of IN cord-024189-t7mbsr25 941 35 life life NN cord-024189-t7mbsr25 941 36 . . . cord-024189-t7mbsr25 942 1 The the DT cord-024189-t7mbsr25 942 2 immune immune JJ cord-024189-t7mbsr25 942 3 complex complex NN cord-024189-t7mbsr25 942 4 - - HYPH cord-024189-t7mbsr25 942 5 mediated mediate VBN cord-024189-t7mbsr25 942 6 vasculitides vasculitide NNS cord-024189-t7mbsr25 942 7 are be VBP cord-024189-t7mbsr25 942 8 a a DT cord-024189-t7mbsr25 942 9 clinically clinically RB cord-024189-t7mbsr25 942 10 heterogeneous heterogeneous JJ cord-024189-t7mbsr25 942 11 group group NN cord-024189-t7mbsr25 942 12 of of IN cord-024189-t7mbsr25 942 13 disorders disorder NNS cord-024189-t7mbsr25 942 14 linked link VBN cord-024189-t7mbsr25 942 15 by by IN cord-024189-t7mbsr25 942 16 ineffi ineffi NNP cord-024189-t7mbsr25 942 17 cient cient NNP cord-024189-t7mbsr25 942 18 , , , cord-024189-t7mbsr25 942 19 defective defective JJ cord-024189-t7mbsr25 942 20 , , , cord-024189-t7mbsr25 942 21 or or CC cord-024189-t7mbsr25 942 22 dysregulated dysregulated JJ cord-024189-t7mbsr25 942 23 clearance clearance NN cord-024189-t7mbsr25 942 24 of of IN cord-024189-t7mbsr25 942 25 immune immune JJ cord-024189-t7mbsr25 942 26 complexes complex NNS cord-024189-t7mbsr25 942 27 by by IN cord-024189-t7mbsr25 942 28 the the DT cord-024189-t7mbsr25 942 29 reticuloendothelial reticuloendothelial JJ cord-024189-t7mbsr25 942 30 system system NN cord-024189-t7mbsr25 942 31 . . . cord-024189-t7mbsr25 943 1 Biopsy biopsy NN cord-024189-t7mbsr25 943 2 of of IN cord-024189-t7mbsr25 943 3 an an DT cord-024189-t7mbsr25 943 4 involved involved JJ cord-024189-t7mbsr25 943 5 organ organ NN cord-024189-t7mbsr25 943 6 is be VBZ cord-024189-t7mbsr25 943 7 frequently frequently RB cord-024189-t7mbsr25 943 8 helpful helpful JJ cord-024189-t7mbsr25 943 9 in in IN cord-024189-t7mbsr25 943 10 establishing establish VBG cord-024189-t7mbsr25 943 11 the the DT cord-024189-t7mbsr25 943 12 diagnosis diagnosis NN cord-024189-t7mbsr25 943 13 . . . cord-024189-t7mbsr25 944 1 Direct direct JJ cord-024189-t7mbsr25 944 2 immunofl immunofl NN cord-024189-t7mbsr25 944 3 uorescence uorescence NN cord-024189-t7mbsr25 944 4 studies study NNS cord-024189-t7mbsr25 944 5 of of IN cord-024189-t7mbsr25 944 6 involved involve VBN cord-024189-t7mbsr25 944 7 blood blood NN cord-024189-t7mbsr25 944 8 vessels vessel NNS cord-024189-t7mbsr25 944 9 demonstrate demonstrate VBP cord-024189-t7mbsr25 944 10 characteristic characteristic JJ cord-024189-t7mbsr25 944 11 patterns pattern NNS cord-024189-t7mbsr25 944 12 of of IN cord-024189-t7mbsr25 944 13 immunoglobulin immunoglobulin NN cord-024189-t7mbsr25 944 14 and and CC cord-024189-t7mbsr25 944 15 complement complement JJ cord-024189-t7mbsr25 944 16 deposition deposition NN cord-024189-t7mbsr25 944 17 , , , cord-024189-t7mbsr25 944 18 which which WDT cord-024189-t7mbsr25 944 19 may may MD cord-024189-t7mbsr25 944 20 be be VB cord-024189-t7mbsr25 944 21 particularly particularly RB cord-024189-t7mbsr25 944 22 useful useful JJ cord-024189-t7mbsr25 944 23 in in IN cord-024189-t7mbsr25 944 24 distinguishing distinguish VBG cord-024189-t7mbsr25 944 25 these these DT cord-024189-t7mbsr25 944 26 diseases disease NNS cord-024189-t7mbsr25 944 27 . . . cord-024189-t7mbsr25 945 1 The the DT cord-024189-t7mbsr25 945 2 prognosis prognosis NN cord-024189-t7mbsr25 945 3 of of IN cord-024189-t7mbsr25 945 4 patients patient NNS cord-024189-t7mbsr25 945 5 with with IN cord-024189-t7mbsr25 945 6 immune immune JJ cord-024189-t7mbsr25 945 7 complex complex NN cord-024189-t7mbsr25 945 8 - - HYPH cord-024189-t7mbsr25 945 9 mediated mediate VBN cord-024189-t7mbsr25 945 10 vasculitis vasculitis NN cord-024189-t7mbsr25 945 11 is be VBZ cord-024189-t7mbsr25 945 12 tied tie VBN cord-024189-t7mbsr25 945 13 closely closely RB cord-024189-t7mbsr25 945 14 to to IN cord-024189-t7mbsr25 945 15 the the DT cord-024189-t7mbsr25 945 16 ability ability NN cord-024189-t7mbsr25 945 17 to to TO cord-024189-t7mbsr25 945 18 identify identify VB cord-024189-t7mbsr25 945 19 and and CC cord-024189-t7mbsr25 945 20 to to TO cord-024189-t7mbsr25 945 21 treat treat VB cord-024189-t7mbsr25 945 22 the the DT cord-024189-t7mbsr25 945 23 underlying underlying JJ cord-024189-t7mbsr25 945 24 cause cause NN cord-024189-t7mbsr25 945 25 of of IN cord-024189-t7mbsr25 945 26 the the DT cord-024189-t7mbsr25 945 27 immune immune JJ cord-024189-t7mbsr25 945 28 response response NN cord-024189-t7mbsr25 945 29 . . . cord-024189-t7mbsr25 946 1 The the DT cord-024189-t7mbsr25 946 2 prevalence prevalence NN cord-024189-t7mbsr25 946 3 of of IN cord-024189-t7mbsr25 946 4 Behçet Behçet NNP cord-024189-t7mbsr25 946 5 's 's POS cord-024189-t7mbsr25 946 6 disease disease NN cord-024189-t7mbsr25 946 7 is be VBZ cord-024189-t7mbsr25 946 8 highest high JJS cord-024189-t7mbsr25 946 9 in in IN cord-024189-t7mbsr25 946 10 countries country NNS cord-024189-t7mbsr25 946 11 of of IN cord-024189-t7mbsr25 946 12 the the DT cord-024189-t7mbsr25 946 13 eastern eastern JJ cord-024189-t7mbsr25 946 14 Mediterranean Mediterranean NNP cord-024189-t7mbsr25 946 15 , , , cord-024189-t7mbsr25 946 16 the the DT cord-024189-t7mbsr25 946 17 Middle Middle NNP cord-024189-t7mbsr25 946 18 East East NNP cord-024189-t7mbsr25 946 19 , , , cord-024189-t7mbsr25 946 20 and and CC cord-024189-t7mbsr25 946 21 East East NNP cord-024189-t7mbsr25 946 22 Asia Asia NNP cord-024189-t7mbsr25 946 23 . . . cord-024189-t7mbsr25 947 1 Aphthous aphthous JJ cord-024189-t7mbsr25 947 2 oral oral JJ cord-024189-t7mbsr25 947 3 ulcers ulcer NNS cord-024189-t7mbsr25 947 4 are be VBP cord-024189-t7mbsr25 947 5 usually usually RB cord-024189-t7mbsr25 947 6 the the DT cord-024189-t7mbsr25 947 7 fi fi NN cord-024189-t7mbsr25 947 8 rst rst NN cord-024189-t7mbsr25 947 9 and and CC cord-024189-t7mbsr25 947 10 most most RBS cord-024189-t7mbsr25 947 11 persistent persistent JJ cord-024189-t7mbsr25 947 12 clinical clinical JJ cord-024189-t7mbsr25 947 13 feature feature NN cord-024189-t7mbsr25 947 14 of of IN cord-024189-t7mbsr25 947 15 Behçet Behçet NNP cord-024189-t7mbsr25 947 16 's 's POS cord-024189-t7mbsr25 947 17 disease disease NN cord-024189-t7mbsr25 947 18 . . . cord-024189-t7mbsr25 948 1 Aphthous Aphthous NNP cord-024189-t7mbsr25 948 2 ulcers ulcer NNS cord-024189-t7mbsr25 948 3 also also RB cord-024189-t7mbsr25 948 4 occur occur VBP cord-024189-t7mbsr25 948 5 frequently frequently RB cord-024189-t7mbsr25 948 6 on on IN cord-024189-t7mbsr25 948 7 the the DT cord-024189-t7mbsr25 948 8 genitals genital NNS cord-024189-t7mbsr25 948 9 ( ( -LRB- cord-024189-t7mbsr25 948 10 e.g. e.g. RB cord-024189-t7mbsr25 948 11 , , , cord-024189-t7mbsr25 948 12 the the DT cord-024189-t7mbsr25 948 13 scrotum scrotum NN cord-024189-t7mbsr25 948 14 or or CC cord-024189-t7mbsr25 948 15 vulva vulva NN cord-024189-t7mbsr25 948 16 ) ) -RRB- cord-024189-t7mbsr25 948 17 . . . cord-024189-t7mbsr25 949 1 Uveitis Uveitis NNP cord-024189-t7mbsr25 949 2 - - : cord-024189-t7mbsr25 949 3 either either CC cord-024189-t7mbsr25 949 4 anterior anterior JJ cord-024189-t7mbsr25 949 5 or or CC cord-024189-t7mbsr25 949 6 posterior posterior JJ cord-024189-t7mbsr25 949 7 - - : cord-024189-t7mbsr25 949 8 is be VBZ cord-024189-t7mbsr25 949 9 common common JJ cord-024189-t7mbsr25 949 10 in in IN cord-024189-t7mbsr25 949 11 Behçet Behçet NNP cord-024189-t7mbsr25 949 12 's 's POS cord-024189-t7mbsr25 949 13 disease disease NN cord-024189-t7mbsr25 949 14 and and CC cord-024189-t7mbsr25 949 15 a a DT cord-024189-t7mbsr25 949 16 source source NN cord-024189-t7mbsr25 949 17 of of IN cord-024189-t7mbsr25 949 18 major major JJ cord-024189-t7mbsr25 949 19 morbidity morbidity NN cord-024189-t7mbsr25 949 20 . . . cord-024189-t7mbsr25 950 1 Many many JJ cord-024189-t7mbsr25 950 2 forms form NNS cord-024189-t7mbsr25 950 3 of of IN cord-024189-t7mbsr25 950 4 central central JJ cord-024189-t7mbsr25 950 5 nervous nervous JJ cord-024189-t7mbsr25 950 6 system system NN cord-024189-t7mbsr25 950 7 disease disease NN cord-024189-t7mbsr25 950 8 may may MD cord-024189-t7mbsr25 950 9 occur occur VB cord-024189-t7mbsr25 950 10 in in IN cord-024189-t7mbsr25 950 11 Behçet Behçet NNP cord-024189-t7mbsr25 950 12 's 's POS cord-024189-t7mbsr25 950 13 disease disease NN cord-024189-t7mbsr25 950 14 . . . cord-024189-t7mbsr25 951 1 These these DT cord-024189-t7mbsr25 951 2 include include VBP cord-024189-t7mbsr25 951 3 aseptic aseptic JJ cord-024189-t7mbsr25 951 4 meningitis meningitis NN cord-024189-t7mbsr25 951 5 and and CC cord-024189-t7mbsr25 951 6 white white JJ cord-024189-t7mbsr25 951 7 matter matter NN cord-024189-t7mbsr25 951 8 lesions lesion NNS cord-024189-t7mbsr25 951 9 in in IN cord-024189-t7mbsr25 951 10 the the DT cord-024189-t7mbsr25 951 11 brainstem brainstem NN cord-024189-t7mbsr25 951 12 . . . cord-024189-t7mbsr25 952 1 Human human JJ cord-024189-t7mbsr25 952 2 leukocyte leukocyte NN cord-024189-t7mbsr25 952 3 antigen antigen NN cord-024189-t7mbsr25 952 4 ( ( -LRB- cord-024189-t7mbsr25 952 5 HLA)-B51 HLA)-B51 NNP cord-024189-t7mbsr25 952 6 is be VBZ cord-024189-t7mbsr25 952 7 a a DT cord-024189-t7mbsr25 952 8 strong strong JJ cord-024189-t7mbsr25 952 9 risk risk NN cord-024189-t7mbsr25 952 10 factor factor NN cord-024189-t7mbsr25 952 11 for for IN cord-024189-t7mbsr25 952 12 Behçet Behçet NNP cord-024189-t7mbsr25 952 13 's 's POS cord-024189-t7mbsr25 952 14 disease disease NN cord-024189-t7mbsr25 952 15 . . . cord-024189-t7mbsr25 953 1 The the DT cord-024189-t7mbsr25 953 2 diagnosis diagnosis NN cord-024189-t7mbsr25 953 3 of of IN cord-024189-t7mbsr25 953 4 primary primary JJ cord-024189-t7mbsr25 953 5 angiitis angiitis NN cord-024189-t7mbsr25 953 6 of of IN cord-024189-t7mbsr25 953 7 the the DT cord-024189-t7mbsr25 953 8 central central JJ cord-024189-t7mbsr25 953 9 nervous nervous JJ cord-024189-t7mbsr25 953 10 system system NN cord-024189-t7mbsr25 953 11 is be VBZ cord-024189-t7mbsr25 953 12 predicated predicate VBN cord-024189-t7mbsr25 953 13 upon upon IN cord-024189-t7mbsr25 953 14 either either CC cord-024189-t7mbsr25 953 15 biopsy biopsy JJ cord-024189-t7mbsr25 953 16 evidence evidence NN cord-024189-t7mbsr25 953 17 of of IN cord-024189-t7mbsr25 953 18 vasculitis vasculitis NN cord-024189-t7mbsr25 953 19 or or CC cord-024189-t7mbsr25 953 20 angiographic angiographic JJ cord-024189-t7mbsr25 953 21 fi fi NN cord-024189-t7mbsr25 953 22 ndings nding NNS cord-024189-t7mbsr25 953 23 suggestive suggestive JJ cord-024189-t7mbsr25 953 24 of of IN cord-024189-t7mbsr25 953 25 vasculitis vasculitis NN cord-024189-t7mbsr25 953 26 in in IN cord-024189-t7mbsr25 953 27 the the DT cord-024189-t7mbsr25 953 28 setting setting NN cord-024189-t7mbsr25 953 29 of of IN cord-024189-t7mbsr25 953 30 other other JJ cord-024189-t7mbsr25 953 31 compelling compelling JJ cord-024189-t7mbsr25 953 32 features feature NNS cord-024189-t7mbsr25 953 33 , , , cord-024189-t7mbsr25 953 34 for for IN cord-024189-t7mbsr25 953 35 example example NN cord-024189-t7mbsr25 953 36 , , , cord-024189-t7mbsr25 953 37 strokes stroke NNS cord-024189-t7mbsr25 953 38 demonstrated demonstrate VBN cord-024189-t7mbsr25 953 39 by by IN cord-024189-t7mbsr25 953 40 magnetic magnetic JJ cord-024189-t7mbsr25 953 41 resonance resonance NN cord-024189-t7mbsr25 953 42 imaging imaging NN cord-024189-t7mbsr25 953 43 or or CC cord-024189-t7mbsr25 953 44 the the DT cord-024189-t7mbsr25 953 45 fi fi NNP cord-024189-t7mbsr25 953 46 ndings nding NNS cord-024189-t7mbsr25 953 47 of of IN cord-024189-t7mbsr25 953 48 a a DT cord-024189-t7mbsr25 953 49 cerebrospinal cerebrospinal JJ cord-024189-t7mbsr25 953 50 fl fl NNP cord-024189-t7mbsr25 953 51 uid uid NNP cord-024189-t7mbsr25 953 52 pleocytosis pleocytosis NNP cord-024189-t7mbsr25 953 53 . . . cord-024189-t7mbsr25 954 1 The the DT cord-024189-t7mbsr25 954 2 diagnosis diagnosis NN cord-024189-t7mbsr25 954 3 of of IN cord-024189-t7mbsr25 954 4 primary primary JJ cord-024189-t7mbsr25 954 5 angiitis angiitis NN cord-024189-t7mbsr25 954 6 of of IN cord-024189-t7mbsr25 954 7 the the DT cord-024189-t7mbsr25 954 8 central central JJ cord-024189-t7mbsr25 954 9 nervous nervous JJ cord-024189-t7mbsr25 954 10 system system NN cord-024189-t7mbsr25 954 11 should should MD cord-024189-t7mbsr25 954 12 never never RB cord-024189-t7mbsr25 954 13 be be VB cord-024189-t7mbsr25 954 14 made make VBN cord-024189-t7mbsr25 954 15 on on IN cord-024189-t7mbsr25 954 16 the the DT cord-024189-t7mbsr25 954 17 basis basis NN cord-024189-t7mbsr25 954 18 of of IN cord-024189-t7mbsr25 954 19 an an DT cord-024189-t7mbsr25 954 20 angiogram angiogram NN cord-024189-t7mbsr25 954 21 alone alone RB cord-024189-t7mbsr25 954 22 . . . cord-024189-t7mbsr25 955 1 Patients patient NNS cord-024189-t7mbsr25 955 2 with with IN cord-024189-t7mbsr25 955 3 benign benign JJ cord-024189-t7mbsr25 955 4 angiopathy angiopathy NNS cord-024189-t7mbsr25 955 5 of of IN cord-024189-t7mbsr25 955 6 the the DT cord-024189-t7mbsr25 955 7 central central JJ cord-024189-t7mbsr25 955 8 nervous nervous JJ cord-024189-t7mbsr25 955 9 system system NN cord-024189-t7mbsr25 955 10 are be VBP cord-024189-t7mbsr25 955 11 predominantly predominantly RB cord-024189-t7mbsr25 955 12 female female JJ cord-024189-t7mbsr25 955 13 , , , cord-024189-t7mbsr25 955 14 tend tend VBP cord-024189-t7mbsr25 955 15 to to TO cord-024189-t7mbsr25 955 16 present present VB cord-024189-t7mbsr25 955 17 acutely acutely RB cord-024189-t7mbsr25 955 18 with with IN cord-024189-t7mbsr25 955 19 headache headache NN cord-024189-t7mbsr25 955 20 ( ( -LRB- cord-024189-t7mbsr25 955 21 with with IN cord-024189-t7mbsr25 955 22 or or CC cord-024189-t7mbsr25 955 23 without without IN cord-024189-t7mbsr25 955 24 focal focal JJ cord-024189-t7mbsr25 955 25 symptoms symptom NNS cord-024189-t7mbsr25 955 26 ) ) -RRB- cord-024189-t7mbsr25 955 27 , , , cord-024189-t7mbsr25 955 28 and and CC cord-024189-t7mbsr25 955 29 have have VBP cord-024189-t7mbsr25 955 30 normal normal JJ cord-024189-t7mbsr25 955 31 or or CC cord-024189-t7mbsr25 955 32 near near IN cord-024189-t7mbsr25 955 33 normal normal JJ cord-024189-t7mbsr25 955 34 cerebrospinal cerebrospinal JJ cord-024189-t7mbsr25 955 35 fl fl NNP cord-024189-t7mbsr25 955 36 uid uid NN cord-024189-t7mbsr25 955 37 . . . cord-024189-t7mbsr25 956 1 Cogan Cogan NNP cord-024189-t7mbsr25 956 2 's 's POS cord-024189-t7mbsr25 956 3 syndrome syndrome NN cord-024189-t7mbsr25 956 4 refers refer VBZ cord-024189-t7mbsr25 956 5 to to IN cord-024189-t7mbsr25 956 6 the the DT cord-024189-t7mbsr25 956 7 association association NNP cord-024189-t7mbsr25 956 8 of of IN cord-024189-t7mbsr25 956 9 infl infl NNP cord-024189-t7mbsr25 956 10 ammation ammation NNP cord-024189-t7mbsr25 956 11 in in IN cord-024189-t7mbsr25 956 12 both both CC cord-024189-t7mbsr25 956 13 the the DT cord-024189-t7mbsr25 956 14 eyes eye NNS cord-024189-t7mbsr25 956 15 and and CC cord-024189-t7mbsr25 956 16 ears ear NNS cord-024189-t7mbsr25 956 17 : : : cord-024189-t7mbsr25 956 18 specifi specifi NNP cord-024189-t7mbsr25 956 19 cally cally RB cord-024189-t7mbsr25 956 20 , , , cord-024189-t7mbsr25 956 21 the the DT cord-024189-t7mbsr25 956 22 occurrence occurrence NN cord-024189-t7mbsr25 956 23 of of IN cord-024189-t7mbsr25 956 24 nonsyphilitic nonsyphilitic JJ cord-024189-t7mbsr25 956 25 interstitial interstitial JJ cord-024189-t7mbsr25 956 26 keratitis keratitis NN cord-024189-t7mbsr25 956 27 and and CC cord-024189-t7mbsr25 956 28 immune immune NN cord-024189-t7mbsr25 956 29 - - HYPH cord-024189-t7mbsr25 956 30 mediated mediate VBN cord-024189-t7mbsr25 956 31 inner inner JJ cord-024189-t7mbsr25 956 32 ear ear NN cord-024189-t7mbsr25 956 33 disease disease NN cord-024189-t7mbsr25 956 34 , , , cord-024189-t7mbsr25 956 35 resulting result VBG cord-024189-t7mbsr25 956 36 in in IN cord-024189-t7mbsr25 956 37 audiovestibular audiovestibular NNP cord-024189-t7mbsr25 956 38 dysfunction dysfunction NN cord-024189-t7mbsr25 956 39 . . . cord-024189-t7mbsr25 957 1 Any any DT cord-024189-t7mbsr25 957 2 type type NN cord-024189-t7mbsr25 957 3 of of IN cord-024189-t7mbsr25 957 4 ocular ocular JJ cord-024189-t7mbsr25 957 5 infl infl NN cord-024189-t7mbsr25 957 6 ammation ammation NN cord-024189-t7mbsr25 957 7 may may MD cord-024189-t7mbsr25 957 8 occur occur VB cord-024189-t7mbsr25 957 9 in in IN cord-024189-t7mbsr25 957 10 Cogan Cogan NNP cord-024189-t7mbsr25 957 11 's 's POS cord-024189-t7mbsr25 957 12 syndrome syndrome NN cord-024189-t7mbsr25 957 13 ( ( -LRB- cord-024189-t7mbsr25 957 14 e.g. e.g. RB cord-024189-t7mbsr25 957 15 , , , cord-024189-t7mbsr25 957 16 scleritis scleritis NNP cord-024189-t7mbsr25 957 17 , , , cord-024189-t7mbsr25 957 18 uveitis uveitis NN cord-024189-t7mbsr25 957 19 , , , cord-024189-t7mbsr25 957 20 orbital orbital JJ cord-024189-t7mbsr25 957 21 pseudotumor pseudotumor NN cord-024189-t7mbsr25 957 22 ) ) -RRB- cord-024189-t7mbsr25 957 23 . . . cord-024189-t7mbsr25 958 1 The the DT cord-024189-t7mbsr25 958 2 inner inner JJ cord-024189-t7mbsr25 958 3 ear ear NN cord-024189-t7mbsr25 958 4 disease disease NN cord-024189-t7mbsr25 958 5 associated associate VBN cord-024189-t7mbsr25 958 6 with with IN cord-024189-t7mbsr25 958 7 this this DT cord-024189-t7mbsr25 958 8 condition condition NN cord-024189-t7mbsr25 958 9 often often RB cord-024189-t7mbsr25 958 10 leads lead VBZ cord-024189-t7mbsr25 958 11 to to IN cord-024189-t7mbsr25 958 12 deafness deafness NN cord-024189-t7mbsr25 958 13 . . . cord-024189-t7mbsr25 959 1 In in IN cord-024189-t7mbsr25 959 2 erythema erythema JJ cord-024189-t7mbsr25 959 3 elevatum elevatum NNP cord-024189-t7mbsr25 959 4 diutinum diutinum NN cord-024189-t7mbsr25 959 5 , , , cord-024189-t7mbsr25 959 6 skin skin NN cord-024189-t7mbsr25 959 7 lesions lesion NNS cord-024189-t7mbsr25 959 8 consist consist VBP cord-024189-t7mbsr25 959 9 of of IN cord-024189-t7mbsr25 959 10 purple purple JJ cord-024189-t7mbsr25 959 11 , , , cord-024189-t7mbsr25 959 12 red red JJ cord-024189-t7mbsr25 959 13 , , , cord-024189-t7mbsr25 959 14 or or CC cord-024189-t7mbsr25 959 15 brown brown JJ cord-024189-t7mbsr25 959 16 plaques plaque NNS cord-024189-t7mbsr25 959 17 and and CC cord-024189-t7mbsr25 959 18 often often RB cord-024189-t7mbsr25 959 19 have have VBP cord-024189-t7mbsr25 959 20 an an DT cord-024189-t7mbsr25 959 21 annular annular JJ cord-024189-t7mbsr25 959 22 or or CC cord-024189-t7mbsr25 959 23 nodular nodular JJ cord-024189-t7mbsr25 959 24 appearance appearance NN cord-024189-t7mbsr25 959 25 . . . cord-024189-t7mbsr25 960 1 The the DT cord-024189-t7mbsr25 960 2 skin skin NN cord-024189-t7mbsr25 960 3 lesions lesion NNS cord-024189-t7mbsr25 960 4 have have VBP cord-024189-t7mbsr25 960 5 a a DT cord-024189-t7mbsr25 960 6 predilection predilection NN cord-024189-t7mbsr25 960 7 for for IN cord-024189-t7mbsr25 960 8 the the DT cord-024189-t7mbsr25 960 9 extensor extensor JJ cord-024189-t7mbsr25 960 10 surfaces surface NNS cord-024189-t7mbsr25 960 11 of of IN cord-024189-t7mbsr25 960 12 the the DT cord-024189-t7mbsr25 960 13 distal distal JJ cord-024189-t7mbsr25 960 14 extremities extremity NNS cord-024189-t7mbsr25 960 15 and and CC cord-024189-t7mbsr25 960 16 often often RB cord-024189-t7mbsr25 960 17 overlie overlie VBP cord-024189-t7mbsr25 960 18 joints joint NNS cord-024189-t7mbsr25 960 19 , , , cord-024189-t7mbsr25 960 20 but but CC cord-024189-t7mbsr25 960 21 may may MD cord-024189-t7mbsr25 960 22 be be VB cord-024189-t7mbsr25 960 23 generalized generalize VBN cord-024189-t7mbsr25 960 24 . . . cord-024189-t7mbsr25 961 1 Behçet Behçet NNP cord-024189-t7mbsr25 961 2 's 's POS cord-024189-t7mbsr25 961 3 disease disease NN cord-024189-t7mbsr25 961 4 ( ( -LRB- cord-024189-t7mbsr25 961 5 BD BD NNP cord-024189-t7mbsr25 961 6 ) ) -RRB- cord-024189-t7mbsr25 961 7 is be VBZ cord-024189-t7mbsr25 961 8 a a DT cord-024189-t7mbsr25 961 9 chronic chronic JJ cord-024189-t7mbsr25 961 10 infl infl NN cord-024189-t7mbsr25 961 11 ammatory ammatory NN cord-024189-t7mbsr25 961 12 disorder disorder NN cord-024189-t7mbsr25 961 13 of of IN cord-024189-t7mbsr25 961 14 unknown unknown JJ cord-024189-t7mbsr25 961 15 cause cause NN cord-024189-t7mbsr25 961 16 . . . cord-024189-t7mbsr25 962 1 Its -PRON- PRP$ cord-024189-t7mbsr25 962 2 manifestations manifestation NNS cord-024189-t7mbsr25 962 3 are be VBP cord-024189-t7mbsr25 962 4 thought think VBN cord-024189-t7mbsr25 962 5 to to TO cord-024189-t7mbsr25 962 6 be be VB cord-024189-t7mbsr25 962 7 caused cause VBN cord-024189-t7mbsr25 962 8 by by IN cord-024189-t7mbsr25 962 9 an an DT cord-024189-t7mbsr25 962 10 underlying underlying JJ cord-024189-t7mbsr25 962 11 vasculitis vasculitis NN cord-024189-t7mbsr25 962 12 . . . cord-024189-t7mbsr25 963 1 Although although IN cord-024189-t7mbsr25 963 2 this this DT cord-024189-t7mbsr25 963 3 disease disease NN cord-024189-t7mbsr25 963 4 is be VBZ cord-024189-t7mbsr25 963 5 recognized recognize VBN cord-024189-t7mbsr25 963 6 worldwide worldwide RB cord-024189-t7mbsr25 963 7 , , , cord-024189-t7mbsr25 963 8 the the DT cord-024189-t7mbsr25 963 9 prevalence prevalence NN cord-024189-t7mbsr25 963 10 is be VBZ cord-024189-t7mbsr25 963 11 highest high JJS cord-024189-t7mbsr25 963 12 in in IN cord-024189-t7mbsr25 963 13 countries country NNS cord-024189-t7mbsr25 963 14 of of IN cord-024189-t7mbsr25 963 15 the the DT cord-024189-t7mbsr25 963 16 eastern eastern JJ cord-024189-t7mbsr25 963 17 Mediterranean Mediterranean NNP cord-024189-t7mbsr25 963 18 , , , cord-024189-t7mbsr25 963 19 the the DT cord-024189-t7mbsr25 963 20 Middle Middle NNP cord-024189-t7mbsr25 963 21 East East NNP cord-024189-t7mbsr25 963 22 , , , cord-024189-t7mbsr25 963 23 and and CC cord-024189-t7mbsr25 963 24 East East NNP cord-024189-t7mbsr25 963 25 Asia Asia NNP cord-024189-t7mbsr25 963 26 , , , cord-024189-t7mbsr25 963 27 thus thus RB cord-024189-t7mbsr25 963 28 the the DT cord-024189-t7mbsr25 963 29 name name NN cord-024189-t7mbsr25 963 30 Silk Silk NNP cord-024189-t7mbsr25 963 31 Road Road NNP cord-024189-t7mbsr25 963 32 disease disease NN cord-024189-t7mbsr25 963 33 . . . cord-024189-t7mbsr25 964 1 The the DT cord-024189-t7mbsr25 964 2 disease disease NN cord-024189-t7mbsr25 964 3 tends tend VBZ cord-024189-t7mbsr25 964 4 to to TO cord-024189-t7mbsr25 964 5 be be VB cord-024189-t7mbsr25 964 6 more more RBR cord-024189-t7mbsr25 964 7 severe severe JJ cord-024189-t7mbsr25 964 8 in in IN cord-024189-t7mbsr25 964 9 areas area NNS cord-024189-t7mbsr25 964 10 where where WRB cord-024189-t7mbsr25 964 11 it -PRON- PRP cord-024189-t7mbsr25 964 12 is be VBZ cord-024189-t7mbsr25 964 13 more more RBR cord-024189-t7mbsr25 964 14 common common JJ cord-024189-t7mbsr25 964 15 . . . cord-024189-t7mbsr25 965 1 Prevalence prevalence NN cord-024189-t7mbsr25 965 2 rates rate NNS cord-024189-t7mbsr25 965 3 in in IN cord-024189-t7mbsr25 965 4 all all DT cord-024189-t7mbsr25 965 5 areas area NNS cord-024189-t7mbsr25 965 6 of of IN cord-024189-t7mbsr25 965 7 the the DT cord-024189-t7mbsr25 965 8 world world NN cord-024189-t7mbsr25 965 9 are be VBP cord-024189-t7mbsr25 965 10 increasing increase VBG cord-024189-t7mbsr25 965 11 , , , cord-024189-t7mbsr25 965 12 probably probably RB cord-024189-t7mbsr25 965 13 because because IN cord-024189-t7mbsr25 965 14 of of IN cord-024189-t7mbsr25 965 15 improved improved JJ cord-024189-t7mbsr25 965 16 recognition recognition NN cord-024189-t7mbsr25 965 17 and and CC cord-024189-t7mbsr25 965 18 reporting reporting NN cord-024189-t7mbsr25 965 19 . . . cord-024189-t7mbsr25 966 1 Behçet Behçet NNP cord-024189-t7mbsr25 966 2 's 's POS cord-024189-t7mbsr25 966 3 disease disease NN cord-024189-t7mbsr25 966 4 occurs occur VBZ cord-024189-t7mbsr25 966 5 primarily primarily RB cord-024189-t7mbsr25 966 6 in in IN cord-024189-t7mbsr25 966 7 young young JJ cord-024189-t7mbsr25 966 8 adults adult NNS cord-024189-t7mbsr25 966 9 . . . cord-024189-t7mbsr25 967 1 The the DT cord-024189-t7mbsr25 967 2 mean mean JJ cord-024189-t7mbsr25 967 3 age age NN cord-024189-t7mbsr25 967 4 at at IN cord-024189-t7mbsr25 967 5 onset onset NN cord-024189-t7mbsr25 967 6 is be VBZ cord-024189-t7mbsr25 967 7 between between IN cord-024189-t7mbsr25 967 8 25 25 CD cord-024189-t7mbsr25 967 9 and and CC cord-024189-t7mbsr25 967 10 30 30 CD cord-024189-t7mbsr25 967 11 years year NNS cord-024189-t7mbsr25 967 12 . . . cord-024189-t7mbsr25 968 1 The the DT cord-024189-t7mbsr25 968 2 incidence incidence NN cord-024189-t7mbsr25 968 3 of of IN cord-024189-t7mbsr25 968 4 disease disease NN cord-024189-t7mbsr25 968 5 in in IN cord-024189-t7mbsr25 968 6 males male NNS cord-024189-t7mbsr25 968 7 and and CC cord-024189-t7mbsr25 968 8 females female NNS cord-024189-t7mbsr25 968 9 with with IN cord-024189-t7mbsr25 968 10 the the DT cord-024189-t7mbsr25 968 11 disease disease NN cord-024189-t7mbsr25 968 12 is be VBZ cord-024189-t7mbsr25 968 13 approximately approximately RB cord-024189-t7mbsr25 968 14 equal equal JJ cord-024189-t7mbsr25 968 15 along along IN cord-024189-t7mbsr25 968 16 the the DT cord-024189-t7mbsr25 968 17 Silk Silk NNP cord-024189-t7mbsr25 968 18 Road Road NNP cord-024189-t7mbsr25 968 19 , , , cord-024189-t7mbsr25 968 20 but but CC cord-024189-t7mbsr25 968 21 in in IN cord-024189-t7mbsr25 968 22 Japan Japan NNP cord-024189-t7mbsr25 968 23 , , , cord-024189-t7mbsr25 968 24 Korea Korea NNP cord-024189-t7mbsr25 968 25 , , , cord-024189-t7mbsr25 968 26 and and CC cord-024189-t7mbsr25 968 27 Western western JJ cord-024189-t7mbsr25 968 28 countries country NNS cord-024189-t7mbsr25 969 1 the the DT cord-024189-t7mbsr25 969 2 disease disease NN cord-024189-t7mbsr25 969 3 occurs occur VBZ cord-024189-t7mbsr25 969 4 more more RBR cord-024189-t7mbsr25 969 5 frequently frequently RB cord-024189-t7mbsr25 969 6 in in IN cord-024189-t7mbsr25 969 7 women woman NNS cord-024189-t7mbsr25 969 8 . . . cord-024189-t7mbsr25 970 1 Familial familial JJ cord-024189-t7mbsr25 970 2 aggregation aggregation NN cord-024189-t7mbsr25 970 3 and and CC cord-024189-t7mbsr25 970 4 juvenile juvenile JJ cord-024189-t7mbsr25 970 5 cases case NNS cord-024189-t7mbsr25 970 6 are be VBP cord-024189-t7mbsr25 970 7 not not RB cord-024189-t7mbsr25 970 8 common common JJ cord-024189-t7mbsr25 970 9 . . . cord-024189-t7mbsr25 971 1 Case case NN cord-024189-t7mbsr25 971 2 confi confi NN cord-024189-t7mbsr25 971 3 rmation rmation NN cord-024189-t7mbsr25 971 4 can can MD cord-024189-t7mbsr25 971 5 be be VB cord-024189-t7mbsr25 971 6 challenging challenging JJ cord-024189-t7mbsr25 971 7 because because IN cord-024189-t7mbsr25 971 8 many many JJ cord-024189-t7mbsr25 971 9 patients patient NNS cord-024189-t7mbsr25 971 10 labeled label VBN cord-024189-t7mbsr25 971 11 as as IN cord-024189-t7mbsr25 971 12 having have VBG cord-024189-t7mbsr25 971 13 Behçet Behçet NNP cord-024189-t7mbsr25 971 14 's 's POS cord-024189-t7mbsr25 971 15 disease disease NN cord-024189-t7mbsr25 971 16 have have VBP cord-024189-t7mbsr25 971 17 oral oral JJ cord-024189-t7mbsr25 971 18 ulcers ulcer NNS cord-024189-t7mbsr25 971 19 as as IN cord-024189-t7mbsr25 971 20 the the DT cord-024189-t7mbsr25 971 21 primary primary JJ cord-024189-t7mbsr25 971 22 or or CC cord-024189-t7mbsr25 971 23 sole sole JJ cord-024189-t7mbsr25 971 24 manifestation manifestation NN cord-024189-t7mbsr25 971 25 . . . cord-024189-t7mbsr25 972 1 Aphthous aphthous JJ cord-024189-t7mbsr25 972 2 oral oral JJ cord-024189-t7mbsr25 972 3 ulcers ulcer NNS cord-024189-t7mbsr25 972 4 are be VBP cord-024189-t7mbsr25 972 5 usually usually RB cord-024189-t7mbsr25 972 6 the the DT cord-024189-t7mbsr25 972 7 fi fi NN cord-024189-t7mbsr25 972 8 rst rst NN cord-024189-t7mbsr25 972 9 and and CC cord-024189-t7mbsr25 972 10 most most RBS cord-024189-t7mbsr25 972 11 persistent persistent JJ cord-024189-t7mbsr25 972 12 clinical clinical JJ cord-024189-t7mbsr25 972 13 feature feature NN cord-024189-t7mbsr25 972 14 of of IN cord-024189-t7mbsr25 972 15 BD BD NNP cord-024189-t7mbsr25 972 16 . . . cord-024189-t7mbsr25 973 1 Lesions lesion NNS cord-024189-t7mbsr25 973 2 occur occur VBP cord-024189-t7mbsr25 973 3 in in IN cord-024189-t7mbsr25 973 4 crops crop NNS cord-024189-t7mbsr25 973 5 and and CC cord-024189-t7mbsr25 973 6 some some DT cord-024189-t7mbsr25 973 7 patients patient NNS cord-024189-t7mbsr25 973 8 may may MD cord-024189-t7mbsr25 973 9 have have VB cord-024189-t7mbsr25 973 10 them -PRON- PRP cord-024189-t7mbsr25 973 11 during during IN cord-024189-t7mbsr25 973 12 most most JJS cord-024189-t7mbsr25 973 13 of of IN cord-024189-t7mbsr25 973 14 the the DT cord-024189-t7mbsr25 973 15 course course NN cord-024189-t7mbsr25 973 16 of of IN cord-024189-t7mbsr25 973 17 the the DT cord-024189-t7mbsr25 973 18 disease disease NN cord-024189-t7mbsr25 973 19 . . . cord-024189-t7mbsr25 974 1 Aphthae aphthae NN cord-024189-t7mbsr25 974 2 occur occur VBP cord-024189-t7mbsr25 974 3 as as IN cord-024189-t7mbsr25 974 4 ulcers ulcer NNS cord-024189-t7mbsr25 974 5 that that WDT cord-024189-t7mbsr25 974 6 are be VBP cord-024189-t7mbsr25 974 7 2 2 CD cord-024189-t7mbsr25 974 8 to to TO cord-024189-t7mbsr25 974 9 12 12 CD cord-024189-t7mbsr25 974 10 mm mm NNS cord-024189-t7mbsr25 974 11 or or CC cord-024189-t7mbsr25 974 12 larger large JJR cord-024189-t7mbsr25 974 13 . . . cord-024189-t7mbsr25 975 1 These these DT cord-024189-t7mbsr25 975 2 are be VBP cord-024189-t7mbsr25 975 3 discrete discrete JJ cord-024189-t7mbsr25 975 4 , , , cord-024189-t7mbsr25 975 5 painful painful JJ cord-024189-t7mbsr25 975 6 , , , cord-024189-t7mbsr25 975 7 round round JJ cord-024189-t7mbsr25 975 8 or or CC cord-024189-t7mbsr25 975 9 oval oval JJ cord-024189-t7mbsr25 975 10 red red JJ cord-024189-t7mbsr25 975 11 - - HYPH cord-024189-t7mbsr25 975 12 rimmed rimmed JJ cord-024189-t7mbsr25 975 13 lesions lesion NNS cord-024189-t7mbsr25 975 14 that that WDT cord-024189-t7mbsr25 975 15 affect affect VBP cord-024189-t7mbsr25 975 16 mainly mainly RB cord-024189-t7mbsr25 975 17 the the DT cord-024189-t7mbsr25 975 18 nonkeratinized nonkeratinized JJ cord-024189-t7mbsr25 975 19 mucosa mucosa NN cord-024189-t7mbsr25 975 20 of of IN cord-024189-t7mbsr25 975 21 the the DT cord-024189-t7mbsr25 975 22 cheeks cheek NNS cord-024189-t7mbsr25 975 23 , , , cord-024189-t7mbsr25 975 24 the the DT cord-024189-t7mbsr25 975 25 border border NN cord-024189-t7mbsr25 975 26 of of IN cord-024189-t7mbsr25 975 27 the the DT cord-024189-t7mbsr25 975 28 tongue tongue NN cord-024189-t7mbsr25 975 29 , , , cord-024189-t7mbsr25 975 30 the the DT cord-024189-t7mbsr25 975 31 soft soft JJ cord-024189-t7mbsr25 975 32 palate palate NN cord-024189-t7mbsr25 975 33 , , , cord-024189-t7mbsr25 975 34 and and CC cord-024189-t7mbsr25 975 35 the the DT cord-024189-t7mbsr25 975 36 pharynx pharynx NN cord-024189-t7mbsr25 975 37 ( ( -LRB- cord-024189-t7mbsr25 975 38 Figure figure NN cord-024189-t7mbsr25 975 39 21E-1 21e-1 CD cord-024189-t7mbsr25 975 40 ) ) -RRB- cord-024189-t7mbsr25 975 41 . . . cord-024189-t7mbsr25 976 1 Oral oral JJ cord-024189-t7mbsr25 976 2 ulcers ulcer NNS cord-024189-t7mbsr25 976 3 are be VBP cord-024189-t7mbsr25 976 4 identical identical JJ cord-024189-t7mbsr25 976 5 to to IN cord-024189-t7mbsr25 976 6 the the DT cord-024189-t7mbsr25 976 7 lesions lesion NNS cord-024189-t7mbsr25 976 8 of of IN cord-024189-t7mbsr25 976 9 recurrent recurrent JJ cord-024189-t7mbsr25 976 10 aphthous aphthous JJ cord-024189-t7mbsr25 976 11 stomatitis stomatitis NN cord-024189-t7mbsr25 976 12 . . . cord-024189-t7mbsr25 977 1 The the DT cord-024189-t7mbsr25 977 2 severity severity NN cord-024189-t7mbsr25 977 3 and and CC cord-024189-t7mbsr25 977 4 behavior behavior NN cord-024189-t7mbsr25 977 5 of of IN cord-024189-t7mbsr25 977 6 the the DT cord-024189-t7mbsr25 977 7 oral oral JJ cord-024189-t7mbsr25 977 8 ulcers ulcer NNS cord-024189-t7mbsr25 977 9 in in IN cord-024189-t7mbsr25 977 10 BD BD NNP cord-024189-t7mbsr25 977 11 often often RB cord-024189-t7mbsr25 977 12 fi fi VBP cord-024189-t7mbsr25 977 13 t t VBD cord-024189-t7mbsr25 977 14 the the DT cord-024189-t7mbsr25 977 15 description description NN cord-024189-t7mbsr25 977 16 of of IN cord-024189-t7mbsr25 977 17 complex complex JJ cord-024189-t7mbsr25 977 18 aphthosis aphthosis NN cord-024189-t7mbsr25 977 19 , , , cord-024189-t7mbsr25 977 20 in in IN cord-024189-t7mbsr25 977 21 which which WDT cord-024189-t7mbsr25 977 22 multiple multiple JJ cord-024189-t7mbsr25 977 23 , , , cord-024189-t7mbsr25 977 24 recurrent recurrent JJ cord-024189-t7mbsr25 977 25 , , , cord-024189-t7mbsr25 977 26 or or CC cord-024189-t7mbsr25 977 27 persisting persist VBG cord-024189-t7mbsr25 977 28 lesions lesion NNS cord-024189-t7mbsr25 977 29 result result VBP cord-024189-t7mbsr25 977 30 in in IN cord-024189-t7mbsr25 977 31 a a DT cord-024189-t7mbsr25 977 32 severe severe JJ cord-024189-t7mbsr25 977 33 syndrome syndrome NN cord-024189-t7mbsr25 977 34 that that WDT cord-024189-t7mbsr25 977 35 may may MD cord-024189-t7mbsr25 977 36 include include VB cord-024189-t7mbsr25 977 37 perianal perianal JJ cord-024189-t7mbsr25 977 38 or or CC cord-024189-t7mbsr25 977 39 genital genital JJ cord-024189-t7mbsr25 977 40 ulceration ulceration NN cord-024189-t7mbsr25 977 41 . . . cord-024189-t7mbsr25 978 1 Genital genital JJ cord-024189-t7mbsr25 978 2 ulcers ulcer NNS cord-024189-t7mbsr25 978 3 resemble resemble VBP cord-024189-t7mbsr25 978 4 oral oral JJ cord-024189-t7mbsr25 978 5 aphthae aphthae NN cord-024189-t7mbsr25 978 6 but but CC cord-024189-t7mbsr25 978 7 occur occur VBP cord-024189-t7mbsr25 978 8 less less RBR cord-024189-t7mbsr25 978 9 frequently frequently RB cord-024189-t7mbsr25 978 10 . . . cord-024189-t7mbsr25 979 1 They -PRON- PRP cord-024189-t7mbsr25 979 2 occur occur VBP cord-024189-t7mbsr25 979 3 as as RB cord-024189-t7mbsr25 979 4 single single JJ cord-024189-t7mbsr25 979 5 or or CC cord-024189-t7mbsr25 979 6 multiple multiple JJ cord-024189-t7mbsr25 979 7 lesions lesion NNS cord-024189-t7mbsr25 979 8 of of IN cord-024189-t7mbsr25 979 9 the the DT cord-024189-t7mbsr25 979 10 vulva vulva NN cord-024189-t7mbsr25 979 11 and and CC cord-024189-t7mbsr25 979 12 in in IN cord-024189-t7mbsr25 979 13 the the DT cord-024189-t7mbsr25 979 14 vagina vagina NN cord-024189-t7mbsr25 979 15 , , , cord-024189-t7mbsr25 979 16 or or CC cord-024189-t7mbsr25 979 17 on on IN cord-024189-t7mbsr25 979 18 the the DT cord-024189-t7mbsr25 979 19 scrotum scrotum NN cord-024189-t7mbsr25 979 20 or or CC cord-024189-t7mbsr25 979 21 penile penile JJ cord-024189-t7mbsr25 979 22 shaft shaft NN cord-024189-t7mbsr25 979 23 ( ( -LRB- cord-024189-t7mbsr25 979 24 Figure figure NN cord-024189-t7mbsr25 979 25 21E-2 21e-2 CD cord-024189-t7mbsr25 979 26 ) ) -RRB- cord-024189-t7mbsr25 979 27 . . . cord-024189-t7mbsr25 980 1 Genital genital JJ cord-024189-t7mbsr25 980 2 lesions lesion NNS cord-024189-t7mbsr25 980 3 are be VBP cord-024189-t7mbsr25 980 4 usually usually RB cord-024189-t7mbsr25 980 5 painful painful JJ cord-024189-t7mbsr25 980 6 and and CC cord-024189-t7mbsr25 980 7 may may MD cord-024189-t7mbsr25 980 8 result result VB cord-024189-t7mbsr25 980 9 in in IN cord-024189-t7mbsr25 980 10 scarring scarring NN cord-024189-t7mbsr25 980 11 , , , cord-024189-t7mbsr25 980 12 but but CC cord-024189-t7mbsr25 980 13 vaginal vaginal JJ cord-024189-t7mbsr25 980 14 ulcers ulcer NNS cord-024189-t7mbsr25 980 15 may may MD cord-024189-t7mbsr25 980 16 be be VB cord-024189-t7mbsr25 980 17 asymptomatic asymptomatic JJ cord-024189-t7mbsr25 980 18 or or CC cord-024189-t7mbsr25 980 19 only only RB cord-024189-t7mbsr25 980 20 produce produce VB cord-024189-t7mbsr25 980 21 a a DT cord-024189-t7mbsr25 980 22 discharge discharge NN cord-024189-t7mbsr25 980 23 . . . cord-024189-t7mbsr25 981 1 Perianal perianal JJ cord-024189-t7mbsr25 981 2 ulcers ulcer NNS cord-024189-t7mbsr25 981 3 may may MD cord-024189-t7mbsr25 981 4 occur occur VB cord-024189-t7mbsr25 981 5 . . . cord-024189-t7mbsr25 982 1 Skin skin NN cord-024189-t7mbsr25 982 2 lesions lesion NNS cord-024189-t7mbsr25 982 3 are be VBP cord-024189-t7mbsr25 982 4 common common JJ cord-024189-t7mbsr25 982 5 in in IN cord-024189-t7mbsr25 982 6 BD BD NNP cord-024189-t7mbsr25 982 7 . . . cord-024189-t7mbsr25 983 1 The the DT cord-024189-t7mbsr25 983 2 International International NNP cord-024189-t7mbsr25 983 3 Study Study NNP cord-024189-t7mbsr25 983 4 Group Group NNP cord-024189-t7mbsr25 983 5 ( ( -LRB- cord-024189-t7mbsr25 983 6 ISG ISG NNP cord-024189-t7mbsr25 983 7 ) ) -RRB- cord-024189-t7mbsr25 983 8 criteria criterion NNS cord-024189-t7mbsr25 983 9 for for IN cord-024189-t7mbsr25 983 10 the the DT cord-024189-t7mbsr25 983 11 diagnosis diagnosis NN cord-024189-t7mbsr25 983 12 of of IN cord-024189-t7mbsr25 983 13 BD BD NNP cord-024189-t7mbsr25 983 14 ( ( -LRB- cord-024189-t7mbsr25 983 15 Table table NN cord-024189-t7mbsr25 983 16 21E- 21e- CD cord-024189-t7mbsr25 983 17 BD BD NNP cord-024189-t7mbsr25 983 18 . . . cord-024189-t7mbsr25 984 1 A a DT cord-024189-t7mbsr25 984 2 neutrophilic neutrophilic NNP cord-024189-t7mbsr25 984 3 infi infi NNP cord-024189-t7mbsr25 984 4 ltrate ltrate NNP cord-024189-t7mbsr25 984 5 is be VBZ cord-024189-t7mbsr25 984 6 typical typical JJ cord-024189-t7mbsr25 984 7 of of IN cord-024189-t7mbsr25 984 8 other other JJ cord-024189-t7mbsr25 984 9 dermatoses dermatosis NNS cord-024189-t7mbsr25 984 10 occasionally occasionally RB cord-024189-t7mbsr25 984 11 seen see VBN cord-024189-t7mbsr25 984 12 with with IN cord-024189-t7mbsr25 984 13 the the DT cord-024189-t7mbsr25 984 14 disorder disorder NN cord-024189-t7mbsr25 984 15 , , , cord-024189-t7mbsr25 984 16 including include VBG cord-024189-t7mbsr25 984 17 pyoderma pyoderma NN cord-024189-t7mbsr25 984 18 gangrenosum gangrenosum NNP cord-024189-t7mbsr25 984 19 and and CC cord-024189-t7mbsr25 984 20 Sweet Sweet NNP cord-024189-t7mbsr25 984 21 's 's POS cord-024189-t7mbsr25 984 22 syndrome syndrome NN cord-024189-t7mbsr25 984 23 . . . cord-024189-t7mbsr25 985 1 Pathergy Pathergy NNP cord-024189-t7mbsr25 985 2 is be VBZ cord-024189-t7mbsr25 985 3 an an DT cord-024189-t7mbsr25 985 4 excessive excessive JJ cord-024189-t7mbsr25 985 5 skin skin NN cord-024189-t7mbsr25 985 6 response response NN cord-024189-t7mbsr25 985 7 to to IN cord-024189-t7mbsr25 985 8 trauma trauma NN cord-024189-t7mbsr25 985 9 , , , cord-024189-t7mbsr25 985 10 refl refl NNP cord-024189-t7mbsr25 985 11 ecting ecting NNP cord-024189-t7mbsr25 985 12 neutrophil neutrophil NN cord-024189-t7mbsr25 985 13 hyperreactivity hyperreactivity NN cord-024189-t7mbsr25 985 14 , , , cord-024189-t7mbsr25 985 15 and and CC cord-024189-t7mbsr25 985 16 is be VBZ cord-024189-t7mbsr25 985 17 highly highly RB cord-024189-t7mbsr25 985 18 specifi specifi VBN cord-024189-t7mbsr25 985 19 c c NN cord-024189-t7mbsr25 985 20 for for IN cord-024189-t7mbsr25 985 21 BD BD NNP cord-024189-t7mbsr25 985 22 . . . cord-024189-t7mbsr25 986 1 Pathergy Pathergy NNP cord-024189-t7mbsr25 986 2 is be VBZ cord-024189-t7mbsr25 986 3 suggested suggest VBN cord-024189-t7mbsr25 986 4 if if IN cord-024189-t7mbsr25 986 5 there there EX cord-024189-t7mbsr25 986 6 is be VBZ cord-024189-t7mbsr25 986 7 a a DT cord-024189-t7mbsr25 986 8 history history NN cord-024189-t7mbsr25 986 9 of of IN cord-024189-t7mbsr25 986 10 red red JJ cord-024189-t7mbsr25 986 11 papules papule NNS cord-024189-t7mbsr25 986 12 , , , cord-024189-t7mbsr25 986 13 pustules pustule NNS cord-024189-t7mbsr25 986 14 , , , cord-024189-t7mbsr25 986 15 or or CC cord-024189-t7mbsr25 986 16 sterile sterile JJ cord-024189-t7mbsr25 986 17 abscesses abscess NNS cord-024189-t7mbsr25 986 18 after after IN cord-024189-t7mbsr25 986 19 therapeutic therapeutic JJ cord-024189-t7mbsr25 986 20 injections injection NNS cord-024189-t7mbsr25 986 21 , , , cord-024189-t7mbsr25 986 22 at at IN cord-024189-t7mbsr25 986 23 intravenous intravenous JJ cord-024189-t7mbsr25 986 24 catheter catheter NN cord-024189-t7mbsr25 986 25 sites site NNS cord-024189-t7mbsr25 986 26 , , , cord-024189-t7mbsr25 986 27 or or CC cord-024189-t7mbsr25 986 28 after after IN cord-024189-t7mbsr25 986 29 minor minor JJ cord-024189-t7mbsr25 986 30 skin skin NN cord-024189-t7mbsr25 986 31 trauma trauma NN cord-024189-t7mbsr25 986 32 . . . cord-024189-t7mbsr25 987 1 Testing test VBG cord-024189-t7mbsr25 987 2 for for IN cord-024189-t7mbsr25 987 3 pathergy pathergy NNP cord-024189-t7mbsr25 987 4 can can MD cord-024189-t7mbsr25 987 5 be be VB cord-024189-t7mbsr25 987 6 done do VBN cord-024189-t7mbsr25 987 7 with with IN cord-024189-t7mbsr25 987 8 a a DT cord-024189-t7mbsr25 987 9 sterile sterile JJ cord-024189-t7mbsr25 987 10 20-gauge 20-gauge CD cord-024189-t7mbsr25 987 11 needle needle NN cord-024189-t7mbsr25 987 12 , , , cord-024189-t7mbsr25 987 13 used use VBN cord-024189-t7mbsr25 987 14 to to TO cord-024189-t7mbsr25 987 15 penetrate penetrate VB cord-024189-t7mbsr25 987 16 the the DT cord-024189-t7mbsr25 987 17 cleansed cleanse VBN cord-024189-t7mbsr25 987 18 skin skin NN cord-024189-t7mbsr25 987 19 perpendicularly perpendicularly RB cord-024189-t7mbsr25 987 20 to to IN cord-024189-t7mbsr25 987 21 a a DT cord-024189-t7mbsr25 987 22 depth depth NN cord-024189-t7mbsr25 987 23 of of IN cord-024189-t7mbsr25 987 24 approximately approximately RB cord-024189-t7mbsr25 987 25 one one CD cord-024189-t7mbsr25 987 26 quarter quarter NN cord-024189-t7mbsr25 987 27 of of IN cord-024189-t7mbsr25 987 28 an an DT cord-024189-t7mbsr25 987 29 inch inch NN cord-024189-t7mbsr25 987 30 , , , cord-024189-t7mbsr25 987 31 rotated rotate VBN cord-024189-t7mbsr25 987 32 briefl briefl NNP cord-024189-t7mbsr25 987 33 y y NNP cord-024189-t7mbsr25 987 34 on on IN cord-024189-t7mbsr25 987 35 its -PRON- PRP$ cord-024189-t7mbsr25 987 36 axis axis NN cord-024189-t7mbsr25 987 37 , , , cord-024189-t7mbsr25 987 38 and and CC cord-024189-t7mbsr25 987 39 then then RB cord-024189-t7mbsr25 987 40 removed remove VBN cord-024189-t7mbsr25 987 41 . . . cord-024189-t7mbsr25 988 1 After after IN cord-024189-t7mbsr25 988 2 48 48 CD cord-024189-t7mbsr25 988 3 hours hour NNS cord-024189-t7mbsr25 988 4 , , , cord-024189-t7mbsr25 988 5 the the DT cord-024189-t7mbsr25 988 6 appearance appearance NN cord-024189-t7mbsr25 988 7 of of IN cord-024189-t7mbsr25 988 8 an an DT cord-024189-t7mbsr25 988 9 erythematous erythematous JJ cord-024189-t7mbsr25 988 10 papule papule NN cord-024189-t7mbsr25 988 11 or or CC cord-024189-t7mbsr25 988 12 pustule pustule NN cord-024189-t7mbsr25 988 13 at at IN cord-024189-t7mbsr25 988 14 the the DT cord-024189-t7mbsr25 988 15 puncture puncture NN cord-024189-t7mbsr25 988 16 site site NN cord-024189-t7mbsr25 988 17 constitutes constitute VBZ cord-024189-t7mbsr25 988 18 a a DT cord-024189-t7mbsr25 988 19 positive positive JJ cord-024189-t7mbsr25 988 20 test test NN cord-024189-t7mbsr25 988 21 . . . cord-024189-t7mbsr25 989 1 The the DT cord-024189-t7mbsr25 989 2 volar volar JJ cord-024189-t7mbsr25 989 3 forearm forearm NN cord-024189-t7mbsr25 989 4 is be VBZ cord-024189-t7mbsr25 989 5 usually usually RB cord-024189-t7mbsr25 989 6 chosen choose VBN cord-024189-t7mbsr25 989 7 for for IN cord-024189-t7mbsr25 989 8 the the DT cord-024189-t7mbsr25 989 9 test test NN cord-024189-t7mbsr25 989 10 and and CC cord-024189-t7mbsr25 989 11 sensitivity sensitivity NN cord-024189-t7mbsr25 989 12 is be VBZ cord-024189-t7mbsr25 989 13 greater great JJR cord-024189-t7mbsr25 989 14 when when WRB cord-024189-t7mbsr25 989 15 three three CD cord-024189-t7mbsr25 989 16 needle needle NN cord-024189-t7mbsr25 989 17 punctures puncture NNS cord-024189-t7mbsr25 989 18 are be VBP cord-024189-t7mbsr25 989 19 made make VBN cord-024189-t7mbsr25 989 20 . . . cord-024189-t7mbsr25 990 1 The the DT cord-024189-t7mbsr25 990 2 positivity positivity NN cord-024189-t7mbsr25 990 3 of of IN cord-024189-t7mbsr25 990 4 the the DT cord-024189-t7mbsr25 990 5 test test NN cord-024189-t7mbsr25 990 6 may may MD cord-024189-t7mbsr25 990 7 vary vary VB cord-024189-t7mbsr25 990 8 during during IN cord-024189-t7mbsr25 990 9 the the DT cord-024189-t7mbsr25 990 10 course course NN cord-024189-t7mbsr25 990 11 of of IN cord-024189-t7mbsr25 990 12 the the DT cord-024189-t7mbsr25 990 13 disease disease NN cord-024189-t7mbsr25 990 14 and and CC cord-024189-t7mbsr25 990 15 is be VBZ cord-024189-t7mbsr25 990 16 more more RBR cord-024189-t7mbsr25 990 17 likely likely JJ cord-024189-t7mbsr25 990 18 to to TO cord-024189-t7mbsr25 990 19 be be VB cord-024189-t7mbsr25 990 20 positive positive JJ cord-024189-t7mbsr25 990 21 at at IN cord-024189-t7mbsr25 990 22 times time NNS cord-024189-t7mbsr25 990 23 of of IN cord-024189-t7mbsr25 990 24 active active JJ cord-024189-t7mbsr25 990 25 disease disease NN cord-024189-t7mbsr25 990 26 . . . cord-024189-t7mbsr25 991 1 The the DT cord-024189-t7mbsr25 991 2 sensitivity sensitivity NN cord-024189-t7mbsr25 991 3 of of IN cord-024189-t7mbsr25 991 4 the the DT cord-024189-t7mbsr25 991 5 test test NN cord-024189-t7mbsr25 991 6 is be VBZ cord-024189-t7mbsr25 991 7 lower low JJR cord-024189-t7mbsr25 991 8 in in IN cord-024189-t7mbsr25 991 9 Western western JJ cord-024189-t7mbsr25 991 10 countries country NNS cord-024189-t7mbsr25 991 11 than than IN cord-024189-t7mbsr25 991 12 in in IN cord-024189-t7mbsr25 991 13 Silk Silk NNP cord-024189-t7mbsr25 991 14 Road Road NNP cord-024189-t7mbsr25 991 15 countries country NNS cord-024189-t7mbsr25 991 16 , , , cord-024189-t7mbsr25 991 17 but but CC cord-024189-t7mbsr25 991 18 a a DT cord-024189-t7mbsr25 991 19 positive positive JJ cord-024189-t7mbsr25 991 20 test test NN cord-024189-t7mbsr25 991 21 adds add VBZ cord-024189-t7mbsr25 991 22 great great JJ cord-024189-t7mbsr25 991 23 support support NN cord-024189-t7mbsr25 991 24 for for IN cord-024189-t7mbsr25 991 25 the the DT cord-024189-t7mbsr25 991 26 diagnosis diagnosis NN cord-024189-t7mbsr25 991 27 of of IN cord-024189-t7mbsr25 991 28 BD BD NNP cord-024189-t7mbsr25 991 29 . . . cord-024189-t7mbsr25 992 1 Ocular ocular JJ cord-024189-t7mbsr25 992 2 infl infl NN cord-024189-t7mbsr25 992 3 ammation ammation NN cord-024189-t7mbsr25 992 4 typically typically RB cord-024189-t7mbsr25 992 5 follows follow VBZ cord-024189-t7mbsr25 992 6 mucocutaneous mucocutaneous JJ cord-024189-t7mbsr25 992 7 symptoms symptom NNS cord-024189-t7mbsr25 992 8 by by IN cord-024189-t7mbsr25 992 9 a a DT cord-024189-t7mbsr25 992 10 few few JJ cord-024189-t7mbsr25 992 11 years year NNS cord-024189-t7mbsr25 992 12 , , , cord-024189-t7mbsr25 992 13 but but CC cord-024189-t7mbsr25 992 14 it -PRON- PRP cord-024189-t7mbsr25 992 15 often often RB cord-024189-t7mbsr25 992 16 progresses progress VBZ cord-024189-t7mbsr25 992 17 with with IN cord-024189-t7mbsr25 992 18 a a DT cord-024189-t7mbsr25 992 19 chronic chronic NN cord-024189-t7mbsr25 992 20 , , , cord-024189-t7mbsr25 992 21 relapsing relapse VBG cord-024189-t7mbsr25 992 22 course course NN cord-024189-t7mbsr25 992 23 affecting affect VBG cord-024189-t7mbsr25 992 24 both both DT cord-024189-t7mbsr25 992 25 eyes eye NNS cord-024189-t7mbsr25 992 26 . . . cord-024189-t7mbsr25 993 1 The the DT cord-024189-t7mbsr25 993 2 ocular ocular JJ cord-024189-t7mbsr25 993 3 fi fi NN cord-024189-t7mbsr25 993 4 nding nding NN cord-024189-t7mbsr25 993 5 in in IN cord-024189-t7mbsr25 993 6 Behçet Behçet NNP cord-024189-t7mbsr25 993 7 's 's POS cord-024189-t7mbsr25 993 8 original original JJ cord-024189-t7mbsr25 993 9 patients patient NNS cord-024189-t7mbsr25 993 10 was be VBD cord-024189-t7mbsr25 993 11 anterior anterior JJ cord-024189-t7mbsr25 993 12 uveitis uveitis NN cord-024189-t7mbsr25 993 13 associated associate VBN cord-024189-t7mbsr25 993 14 with with IN cord-024189-t7mbsr25 993 15 a a DT cord-024189-t7mbsr25 993 16 hypopyon hypopyon NN cord-024189-t7mbsr25 993 17 [ [ -LRB- cord-024189-t7mbsr25 993 18 the the DT cord-024189-t7mbsr25 993 19 accumulation accumulation NN cord-024189-t7mbsr25 993 20 of of IN cord-024189-t7mbsr25 993 21 an an DT cord-024189-t7mbsr25 993 22 infl infl NNP cord-024189-t7mbsr25 993 23 ammatory ammatory NNP cord-024189-t7mbsr25 993 24 cell cell NN cord-024189-t7mbsr25 993 25 infi infi NNP cord-024189-t7mbsr25 993 26 ltrate ltrate NNP cord-024189-t7mbsr25 993 27 - - : cord-024189-t7mbsr25 993 28 essentially essentially RB cord-024189-t7mbsr25 993 29 pus pus NN cord-024189-t7mbsr25 993 30 - - : cord-024189-t7mbsr25 993 31 in in IN cord-024189-t7mbsr25 993 32 the the DT cord-024189-t7mbsr25 993 33 anterior anterior NNP cord-024189-t7mbsr25 993 34 chamber chamber NN cord-024189-t7mbsr25 993 35 ( ( -LRB- cord-024189-t7mbsr25 993 36 Figure figure NN cord-024189-t7mbsr25 993 37 21E-3 21e-3 CD cord-024189-t7mbsr25 993 38 ) ) -RRB- cord-024189-t7mbsr25 993 39 ] ] -RRB- cord-024189-t7mbsr25 993 40 . . . cord-024189-t7mbsr25 994 1 Anterior anterior JJ cord-024189-t7mbsr25 994 2 uveitis uveitis NN cord-024189-t7mbsr25 994 3 that that WDT cord-024189-t7mbsr25 994 4 is be VBZ cord-024189-t7mbsr25 994 5 not not RB cord-024189-t7mbsr25 994 6 treated treat VBN cord-024189-t7mbsr25 994 7 promptly promptly RB cord-024189-t7mbsr25 994 8 with with IN cord-024189-t7mbsr25 994 9 a a DT cord-024189-t7mbsr25 994 10 mydriatic mydriatic JJ cord-024189-t7mbsr25 994 11 agent agent NN cord-024189-t7mbsr25 994 12 may may MD cord-024189-t7mbsr25 994 13 result result VB cord-024189-t7mbsr25 994 14 in in IN cord-024189-t7mbsr25 994 15 synechiae synechiae NN cord-024189-t7mbsr25 994 16 formation formation NN cord-024189-t7mbsr25 994 17 between between IN cord-024189-t7mbsr25 994 18 the the DT cord-024189-t7mbsr25 994 19 iris iris NN cord-024189-t7mbsr25 994 20 and and CC cord-024189-t7mbsr25 994 21 the the DT cord-024189-t7mbsr25 994 22 lens lens NN cord-024189-t7mbsr25 994 23 and and CC cord-024189-t7mbsr25 994 24 permanent permanent JJ cord-024189-t7mbsr25 994 25 papillary papillary JJ cord-024189-t7mbsr25 994 26 distortion distortion NN cord-024189-t7mbsr25 994 27 . . . cord-024189-t7mbsr25 995 1 The the DT cord-024189-t7mbsr25 995 2 ocular ocular JJ cord-024189-t7mbsr25 995 3 manifestations manifestation NNS cord-024189-t7mbsr25 995 4 of of IN cord-024189-t7mbsr25 995 5 Behçet Behçet NNP cord-024189-t7mbsr25 995 6 's 's POS cord-024189-t7mbsr25 995 7 disease disease NN cord-024189-t7mbsr25 995 8 may may MD cord-024189-t7mbsr25 995 9 also also RB cord-024189-t7mbsr25 995 10 include include VB cord-024189-t7mbsr25 995 11 a a DT cord-024189-t7mbsr25 995 12 panuveitis panuveitis NN cord-024189-t7mbsr25 995 13 , , , cord-024189-t7mbsr25 995 14 however however RB cord-024189-t7mbsr25 995 15 , , , cord-024189-t7mbsr25 995 16 with with IN cord-024189-t7mbsr25 995 17 posterior posterior JJ cord-024189-t7mbsr25 995 18 chamber chamber NN cord-024189-t7mbsr25 995 19 involvement involvement NN cord-024189-t7mbsr25 995 20 and and CC cord-024189-t7mbsr25 995 21 retinal retinal JJ cord-024189-t7mbsr25 995 22 vasculitis vasculitis NN cord-024189-t7mbsr25 995 23 , , , cord-024189-t7mbsr25 995 24 the the DT cord-024189-t7mbsr25 995 25 complications complication NNS cord-024189-t7mbsr25 995 26 of of IN cord-024189-t7mbsr25 995 27 which which WDT cord-024189-t7mbsr25 995 28 may may MD cord-024189-t7mbsr25 995 29 extend extend VB cord-024189-t7mbsr25 995 30 to to IN cord-024189-t7mbsr25 995 31 visual visual JJ cord-024189-t7mbsr25 995 32 loss loss NN cord-024189-t7mbsr25 995 33 . . . cord-024189-t7mbsr25 996 1 Retinal retinal JJ cord-024189-t7mbsr25 996 2 vasculitis vasculitis NN cord-024189-t7mbsr25 996 3 , , , cord-024189-t7mbsr25 996 4 which which WDT cord-024189-t7mbsr25 996 5 leads lead VBZ cord-024189-t7mbsr25 996 6 to to IN cord-024189-t7mbsr25 996 7 episodes episode NNS cord-024189-t7mbsr25 996 8 of of IN cord-024189-t7mbsr25 996 9 retinal retinal JJ cord-024189-t7mbsr25 996 10 occlusion occlusion NN cord-024189-t7mbsr25 996 11 and and CC cord-024189-t7mbsr25 996 12 areas area NNS cord-024189-t7mbsr25 996 13 of of IN cord-024189-t7mbsr25 996 14 ischemia ischemia NN cord-024189-t7mbsr25 996 15 , , , cord-024189-t7mbsr25 996 16 may may MD cord-024189-t7mbsr25 996 17 be be VB cord-024189-t7mbsr25 996 18 followed follow VBN cord-024189-t7mbsr25 996 19 by by IN cord-024189-t7mbsr25 996 20 neovascularization neovascularization NN cord-024189-t7mbsr25 996 21 , , , cord-024189-t7mbsr25 996 22 vitreous vitreous JJ cord-024189-t7mbsr25 996 23 hemorrhage hemorrhage NN cord-024189-t7mbsr25 996 24 and and CC cord-024189-t7mbsr25 996 25 contraction contraction NN cord-024189-t7mbsr25 996 26 , , , cord-024189-t7mbsr25 996 27 glaucoma glaucoma NN cord-024189-t7mbsr25 996 28 , , , cord-024189-t7mbsr25 996 29 and and CC cord-024189-t7mbsr25 996 30 retinal retinal JJ cord-024189-t7mbsr25 996 31 detachment detachment NN cord-024189-t7mbsr25 996 32 . . . cord-024189-t7mbsr25 997 1 The the DT cord-024189-t7mbsr25 997 2 earliest early JJS cord-024189-t7mbsr25 997 3 fi fi NN cord-024189-t7mbsr25 997 4 ndings nding NNS cord-024189-t7mbsr25 997 5 of of IN cord-024189-t7mbsr25 997 6 retinal retinal JJ cord-024189-t7mbsr25 997 7 vasculitis vasculitis NN cord-024189-t7mbsr25 997 8 may may MD cord-024189-t7mbsr25 997 9 be be VB cord-024189-t7mbsr25 997 10 detected detect VBN cord-024189-t7mbsr25 997 11 with with IN cord-024189-t7mbsr25 997 12 fl fl NNP cord-024189-t7mbsr25 997 13 uorescein uorescein NNP cord-024189-t7mbsr25 997 14 angiography angiography NNP cord-024189-t7mbsr25 997 15 . . . cord-024189-t7mbsr25 998 1 Isolated isolate VBN cord-024189-t7mbsr25 998 2 optic optic JJ cord-024189-t7mbsr25 998 3 disk disk NN cord-024189-t7mbsr25 998 4 edema edema NN cord-024189-t7mbsr25 998 5 in in IN cord-024189-t7mbsr25 998 6 BD BD NNP cord-024189-t7mbsr25 998 7 suggests suggest VBZ cord-024189-t7mbsr25 998 8 cerebral cerebral JJ cord-024189-t7mbsr25 998 9 venous venous JJ cord-024189-t7mbsr25 998 10 thrombosis thrombosis NN cord-024189-t7mbsr25 998 11 rather rather RB cord-024189-t7mbsr25 998 12 than than IN cord-024189-t7mbsr25 998 13 ocular ocular JJ cord-024189-t7mbsr25 998 14 disease disease NN cord-024189-t7mbsr25 998 15 , , , cord-024189-t7mbsr25 998 16 but but CC cord-024189-t7mbsr25 998 17 papillitis papillitis NNP cord-024189-t7mbsr25 998 18 may may MD cord-024189-t7mbsr25 998 19 occur occur VB cord-024189-t7mbsr25 998 20 with with IN cord-024189-t7mbsr25 998 21 ocular ocular JJ cord-024189-t7mbsr25 998 22 infl infl NN cord-024189-t7mbsr25 998 23 ammation ammation NN cord-024189-t7mbsr25 998 24 and and CC cord-024189-t7mbsr25 998 25 central central JJ cord-024189-t7mbsr25 998 26 nervous nervous JJ cord-024189-t7mbsr25 998 27 system system NN cord-024189-t7mbsr25 998 28 disease disease NN cord-024189-t7mbsr25 998 29 . . . cord-024189-t7mbsr25 999 1 Cranial cranial JJ cord-024189-t7mbsr25 999 2 nerve nerve NN cord-024189-t7mbsr25 999 3 palsies palsy NNS cord-024189-t7mbsr25 999 4 may may MD cord-024189-t7mbsr25 999 5 result result VB cord-024189-t7mbsr25 999 6 from from IN cord-024189-t7mbsr25 999 7 brain brain NN cord-024189-t7mbsr25 999 8 stem stem NN cord-024189-t7mbsr25 999 9 lesions lesion NNS cord-024189-t7mbsr25 999 10 , , , cord-024189-t7mbsr25 999 11 and and CC cord-024189-t7mbsr25 999 12 visual visual JJ cord-024189-t7mbsr25 999 13 fi fi NN cord-024189-t7mbsr25 999 14 eld eld NN cord-024189-t7mbsr25 999 15 defects defect NNS cord-024189-t7mbsr25 999 16 may may MD cord-024189-t7mbsr25 999 17 also also RB cord-024189-t7mbsr25 999 18 be be VB cord-024189-t7mbsr25 999 19 caused cause VBN cord-024189-t7mbsr25 999 20 by by IN cord-024189-t7mbsr25 999 21 intracranial intracranial JJ cord-024189-t7mbsr25 999 22 disease disease NN cord-024189-t7mbsr25 999 23 involving involve VBG cord-024189-t7mbsr25 999 24 the the DT cord-024189-t7mbsr25 999 25 optic optic JJ cord-024189-t7mbsr25 999 26 pathways pathway NNS cord-024189-t7mbsr25 999 27 . . . cord-024189-t7mbsr25 1000 1 With with IN cord-024189-t7mbsr25 1000 2 cerebral cerebral JJ cord-024189-t7mbsr25 1000 3 venous venous JJ cord-024189-t7mbsr25 1000 4 thrombosis thrombosis NN cord-024189-t7mbsr25 1000 5 , , , cord-024189-t7mbsr25 1000 6 patients patient NNS cord-024189-t7mbsr25 1000 7 usually usually RB cord-024189-t7mbsr25 1000 8 present present JJ cord-024189-t7mbsr25 1000 9 with with IN cord-024189-t7mbsr25 1000 10 symptoms symptom NNS cord-024189-t7mbsr25 1000 11 of of IN cord-024189-t7mbsr25 1000 12 intracranial intracranial JJ cord-024189-t7mbsr25 1000 13 pressure pressure NN cord-024189-t7mbsr25 1000 14 : : : cord-024189-t7mbsr25 1000 15 headache headache NN cord-024189-t7mbsr25 1000 16 , , , cord-024189-t7mbsr25 1000 17 visual visual JJ cord-024189-t7mbsr25 1000 18 obscurations obscuration NNS cord-024189-t7mbsr25 1000 19 , , , cord-024189-t7mbsr25 1000 20 and and CC cord-024189-t7mbsr25 1000 21 papilledema papilledema NNP cord-024189-t7mbsr25 1000 22 . . . cord-024189-t7mbsr25 1001 1 Magnetic magnetic JJ cord-024189-t7mbsr25 1001 2 resonance resonance NN cord-024189-t7mbsr25 1001 3 imaging imaging NN cord-024189-t7mbsr25 1001 4 may may MD cord-024189-t7mbsr25 1001 5 be be VB cord-024189-t7mbsr25 1001 6 used use VBN cord-024189-t7mbsr25 1001 7 to to TO cord-024189-t7mbsr25 1001 8 demonstrate demonstrate VB cord-024189-t7mbsr25 1001 9 acute acute JJ cord-024189-t7mbsr25 1001 10 or or CC cord-024189-t7mbsr25 1001 11 recent recent JJ cord-024189-t7mbsr25 1001 12 clot clot NN cord-024189-t7mbsr25 1001 13 in in IN cord-024189-t7mbsr25 1001 14 the the DT cord-024189-t7mbsr25 1001 15 larger large JJR cord-024189-t7mbsr25 1001 16 dural dural JJ cord-024189-t7mbsr25 1001 17 sinuses sinus NNS cord-024189-t7mbsr25 1001 18 , , , cord-024189-t7mbsr25 1001 19 but but CC cord-024189-t7mbsr25 1001 20 magnetic magnetic JJ cord-024189-t7mbsr25 1001 21 resonance resonance NN cord-024189-t7mbsr25 1001 22 venography venography NN cord-024189-t7mbsr25 1001 23 is be VBZ cord-024189-t7mbsr25 1001 24 more more RBR cord-024189-t7mbsr25 1001 25 reliable reliable JJ cord-024189-t7mbsr25 1001 26 for for IN cord-024189-t7mbsr25 1001 27 recognizing recognize VBG cord-024189-t7mbsr25 1001 28 clot clot NN cord-024189-t7mbsr25 1001 29 in in IN cord-024189-t7mbsr25 1001 30 the the DT cord-024189-t7mbsr25 1001 31 cerebral cerebral JJ cord-024189-t7mbsr25 1001 32 venous venous JJ cord-024189-t7mbsr25 1001 33 system system NN cord-024189-t7mbsr25 1001 34 , , , cord-024189-t7mbsr25 1001 35 especially especially RB cord-024189-t7mbsr25 1001 36 in in IN cord-024189-t7mbsr25 1001 37 the the DT cord-024189-t7mbsr25 1001 38 smaller small JJR cord-024189-t7mbsr25 1001 39 veins vein NNS cord-024189-t7mbsr25 1001 40 and and CC cord-024189-t7mbsr25 1001 41 older old JJR cord-024189-t7mbsr25 1001 42 thromboses thrombose NNS cord-024189-t7mbsr25 1001 43 . . . cord-024189-t7mbsr25 1002 1 Central central JJ cord-024189-t7mbsr25 1002 2 nervous nervous JJ cord-024189-t7mbsr25 1002 3 system system NN cord-024189-t7mbsr25 1002 4 symptoms symptom NNS cord-024189-t7mbsr25 1002 5 in in IN cord-024189-t7mbsr25 1002 6 BD BD NNP cord-024189-t7mbsr25 1002 7 may may MD cord-024189-t7mbsr25 1002 8 be be VB cord-024189-t7mbsr25 1002 9 due due JJ cord-024189-t7mbsr25 1002 10 to to IN cord-024189-t7mbsr25 1002 11 aseptic aseptic JJ cord-024189-t7mbsr25 1002 12 meningitis meningitis NN cord-024189-t7mbsr25 1002 13 or or CC cord-024189-t7mbsr25 1002 14 parenchymal parenchymal JJ cord-024189-t7mbsr25 1002 15 lesions lesion NNS cord-024189-t7mbsr25 1002 16 , , , cord-024189-t7mbsr25 1002 17 resulting result VBG cord-024189-t7mbsr25 1002 18 in in IN cord-024189-t7mbsr25 1002 19 focal focal JJ cord-024189-t7mbsr25 1002 20 or or CC cord-024189-t7mbsr25 1002 21 diffuse diffuse JJ cord-024189-t7mbsr25 1002 22 brain brain NN cord-024189-t7mbsr25 1002 23 dysfunction dysfunction NN cord-024189-t7mbsr25 1002 24 . . . cord-024189-t7mbsr25 1003 1 An an DT cord-024189-t7mbsr25 1003 2 increased increase VBN cord-024189-t7mbsr25 1003 3 protein protein NN cord-024189-t7mbsr25 1003 4 concentration concentration NN cord-024189-t7mbsr25 1003 5 and and CC cord-024189-t7mbsr25 1003 6 lymphocytic lymphocytic JJ cord-024189-t7mbsr25 1003 7 pleocytosis pleocytosis NNP cord-024189-t7mbsr25 1003 8 in in IN cord-024189-t7mbsr25 1003 9 the the DT cord-024189-t7mbsr25 1003 10 cerebrospinal cerebrospinal JJ cord-024189-t7mbsr25 1003 11 fl fl NNP cord-024189-t7mbsr25 1003 12 uid uid NN cord-024189-t7mbsr25 1003 13 ( ( -LRB- cord-024189-t7mbsr25 1003 14 CSF CSF NNP cord-024189-t7mbsr25 1003 15 ) ) -RRB- cord-024189-t7mbsr25 1003 16 is be VBZ cord-024189-t7mbsr25 1003 17 supportive supportive JJ cord-024189-t7mbsr25 1003 18 of of IN cord-024189-t7mbsr25 1003 19 the the DT cord-024189-t7mbsr25 1003 20 diagnosis diagnosis NN cord-024189-t7mbsr25 1003 21 . . . cord-024189-t7mbsr25 1004 1 The the DT cord-024189-t7mbsr25 1004 2 clinical clinical JJ cord-024189-t7mbsr25 1004 3 combination combination NN cord-024189-t7mbsr25 1004 4 of of IN cord-024189-t7mbsr25 1004 5 stroke stroke NN cord-024189-t7mbsr25 1004 6 , , , cord-024189-t7mbsr25 1004 7 aseptic aseptic JJ cord-024189-t7mbsr25 1004 8 meningitis meningitis NN cord-024189-t7mbsr25 1004 9 with with IN cord-024189-t7mbsr25 1004 10 CSF CSF NNP cord-024189-t7mbsr25 1004 11 pleocytosis pleocytosis NNP cord-024189-t7mbsr25 1004 12 , , , cord-024189-t7mbsr25 1004 13 and and CC cord-024189-t7mbsr25 1004 14 mucocutaneous mucocutaneous JJ cord-024189-t7mbsr25 1004 15 lesions lesion NNS cord-024189-t7mbsr25 1004 16 can can MD cord-024189-t7mbsr25 1004 17 be be VB cord-024189-t7mbsr25 1004 18 diagnostic diagnostic JJ cord-024189-t7mbsr25 1004 19 of of IN cord-024189-t7mbsr25 1004 20 BD BD NNP cord-024189-t7mbsr25 1004 21 . . . cord-024189-t7mbsr25 1005 1 Focal focal JJ cord-024189-t7mbsr25 1005 2 or or CC cord-024189-t7mbsr25 1005 3 multifocal multifocal JJ cord-024189-t7mbsr25 1005 4 nervous nervous JJ cord-024189-t7mbsr25 1005 5 system system NN cord-024189-t7mbsr25 1005 6 involvement involvement NN cord-024189-t7mbsr25 1005 7 refl refl NN cord-024189-t7mbsr25 1005 8 ects ects NNP cord-024189-t7mbsr25 1006 1 the the DT cord-024189-t7mbsr25 1006 2 predilection predilection NN cord-024189-t7mbsr25 1006 3 of of IN cord-024189-t7mbsr25 1006 4 the the DT cord-024189-t7mbsr25 1006 5 disease disease NN cord-024189-t7mbsr25 1006 6 for for IN cord-024189-t7mbsr25 1006 7 diencephalon diencephalon NNP cord-024189-t7mbsr25 1006 8 , , , cord-024189-t7mbsr25 1006 9 midbrain midbrain NN cord-024189-t7mbsr25 1006 10 , , , cord-024189-t7mbsr25 1006 11 and and CC cord-024189-t7mbsr25 1006 12 brainstem brainstem NN cord-024189-t7mbsr25 1006 13 ( ( -LRB- cord-024189-t7mbsr25 1006 14 Figure figure NN cord-024189-t7mbsr25 1006 15 21E-4 21e-4 CD cord-024189-t7mbsr25 1006 16 ) ) -RRB- cord-024189-t7mbsr25 1006 17 . . . cord-024189-t7mbsr25 1007 1 In in IN cord-024189-t7mbsr25 1007 2 contrast contrast NN cord-024189-t7mbsr25 1007 3 to to IN cord-024189-t7mbsr25 1007 4 multiple multiple JJ cord-024189-t7mbsr25 1007 5 sclerosis sclerosis NN cord-024189-t7mbsr25 1007 6 , , , cord-024189-t7mbsr25 1007 7 there there EX cord-024189-t7mbsr25 1007 8 is be VBZ cord-024189-t7mbsr25 1007 9 Hypopyon Hypopyon NNP cord-024189-t7mbsr25 1007 10 in in IN cord-024189-t7mbsr25 1007 11 the the DT cord-024189-t7mbsr25 1007 12 anterior anterior NNP cord-024189-t7mbsr25 1007 13 chamber chamber NN cord-024189-t7mbsr25 1007 14 of of IN cord-024189-t7mbsr25 1007 15 a a DT cord-024189-t7mbsr25 1007 16 patient patient NN cord-024189-t7mbsr25 1007 17 with with IN cord-024189-t7mbsr25 1007 18 Behçet Behçet NNP cord-024189-t7mbsr25 1007 19 's 's POS cord-024189-t7mbsr25 1007 20 disease disease NN cord-024189-t7mbsr25 1007 21 , , , cord-024189-t7mbsr25 1007 22 caused cause VBN cord-024189-t7mbsr25 1007 23 by by IN cord-024189-t7mbsr25 1007 24 anterior anterior NNP cord-024189-t7mbsr25 1007 25 uveitis uveitis NN cord-024189-t7mbsr25 1007 26 . . . cord-024189-t7mbsr25 1008 1 Brainstem Brainstem NNP cord-024189-t7mbsr25 1008 2 involvement involvement NN cord-024189-t7mbsr25 1008 3 in in IN cord-024189-t7mbsr25 1008 4 a a DT cord-024189-t7mbsr25 1008 5 patient patient NN cord-024189-t7mbsr25 1008 6 with with IN cord-024189-t7mbsr25 1008 7 Behçet Behçet NNP cord-024189-t7mbsr25 1008 8 's 's POS cord-024189-t7mbsr25 1008 9 disease disease NN cord-024189-t7mbsr25 1008 10 . . . cord-024189-t7mbsr25 1009 1 no no DT cord-024189-t7mbsr25 1009 2 preference preference NN cord-024189-t7mbsr25 1009 3 for for IN cord-024189-t7mbsr25 1009 4 the the DT cord-024189-t7mbsr25 1009 5 periventricular periventricular NNP cord-024189-t7mbsr25 1009 6 structures structure NNS cord-024189-t7mbsr25 1009 7 ( ( -LRB- cord-024189-t7mbsr25 1009 8 2 2 CD cord-024189-t7mbsr25 1009 9 ) ) -RRB- cord-024189-t7mbsr25 1009 10 . . . cord-024189-t7mbsr25 1010 1 Isolated isolated JJ cord-024189-t7mbsr25 1010 2 headaches headache NNS cord-024189-t7mbsr25 1010 3 in in IN cord-024189-t7mbsr25 1010 4 BD BD NNP cord-024189-t7mbsr25 1010 5 are be VBP cord-024189-t7mbsr25 1010 6 common common JJ cord-024189-t7mbsr25 1010 7 but but CC cord-024189-t7mbsr25 1010 8 the the DT cord-024189-t7mbsr25 1010 9 cause cause NN cord-024189-t7mbsr25 1010 10 is be VBZ cord-024189-t7mbsr25 1010 11 not not RB cord-024189-t7mbsr25 1010 12 well well RB cord-024189-t7mbsr25 1010 13 understood understand VBN cord-024189-t7mbsr25 1010 14 . . . cord-024189-t7mbsr25 1011 1 These these DT cord-024189-t7mbsr25 1011 2 may may MD cord-024189-t7mbsr25 1011 3 represent represent VB cord-024189-t7mbsr25 1011 4 secondary secondary JJ cord-024189-t7mbsr25 1011 5 migraine migraine NN cord-024189-t7mbsr25 1011 6 or or CC cord-024189-t7mbsr25 1011 7 may may MD cord-024189-t7mbsr25 1011 8 not not RB cord-024189-t7mbsr25 1011 9 be be VB cord-024189-t7mbsr25 1011 10 related relate VBN cord-024189-t7mbsr25 1011 11 to to IN cord-024189-t7mbsr25 1011 12 the the DT cord-024189-t7mbsr25 1011 13 disease disease NN cord-024189-t7mbsr25 1011 14 . . . cord-024189-t7mbsr25 1012 1 Large large JJ cord-024189-t7mbsr25 1012 2 vessel vessel NN cord-024189-t7mbsr25 1012 3 involvement involvement NN cord-024189-t7mbsr25 1012 4 , , , cord-024189-t7mbsr25 1012 5 which which WDT cord-024189-t7mbsr25 1012 6 occurs occur VBZ cord-024189-t7mbsr25 1012 7 in in IN cord-024189-t7mbsr25 1012 8 about about RB cord-024189-t7mbsr25 1012 9 one one CD cord-024189-t7mbsr25 1012 10 fourth fourth NN cord-024189-t7mbsr25 1012 11 of of IN cord-024189-t7mbsr25 1012 12 patients patient NNS cord-024189-t7mbsr25 1012 13 with with IN cord-024189-t7mbsr25 1012 14 BD BD NNP cord-024189-t7mbsr25 1012 15 , , , cord-024189-t7mbsr25 1012 16 is be VBZ cord-024189-t7mbsr25 1012 17 a a DT cord-024189-t7mbsr25 1012 18 major major JJ cord-024189-t7mbsr25 1012 19 cause cause NN cord-024189-t7mbsr25 1012 20 of of IN cord-024189-t7mbsr25 1012 21 morbidity morbidity NN cord-024189-t7mbsr25 1012 22 and and CC cord-024189-t7mbsr25 1012 23 mortality mortality NN cord-024189-t7mbsr25 1012 24 ( ( -LRB- cord-024189-t7mbsr25 1012 25 3 3 CD cord-024189-t7mbsr25 1012 26 ) ) -RRB- cord-024189-t7mbsr25 1012 27 . . . cord-024189-t7mbsr25 1013 1 Patients patient NNS cord-024189-t7mbsr25 1013 2 with with IN cord-024189-t7mbsr25 1013 3 vascular vascular JJ cord-024189-t7mbsr25 1013 4 disease disease NN cord-024189-t7mbsr25 1013 5 often often RB cord-024189-t7mbsr25 1013 6 have have VBP cord-024189-t7mbsr25 1013 7 multiple multiple JJ cord-024189-t7mbsr25 1013 8 lesions lesion NNS cord-024189-t7mbsr25 1013 9 and and CC cord-024189-t7mbsr25 1013 10 involvement involvement NN cord-024189-t7mbsr25 1013 11 of of IN cord-024189-t7mbsr25 1013 12 both both CC cord-024189-t7mbsr25 1013 13 the the DT cord-024189-t7mbsr25 1013 14 arterial arterial JJ cord-024189-t7mbsr25 1013 15 and and CC cord-024189-t7mbsr25 1013 16 venous venous JJ cord-024189-t7mbsr25 1013 17 systems system NNS cord-024189-t7mbsr25 1013 18 ( ( -LRB- cord-024189-t7mbsr25 1013 19 4 4 CD cord-024189-t7mbsr25 1013 20 ) ) -RRB- cord-024189-t7mbsr25 1013 21 . . . cord-024189-t7mbsr25 1014 1 Deep deep JJ cord-024189-t7mbsr25 1014 2 venous venous JJ cord-024189-t7mbsr25 1014 3 thrombosis thrombosis NN cord-024189-t7mbsr25 1014 4 ( ( -LRB- cord-024189-t7mbsr25 1014 5 DVT DVT NNP cord-024189-t7mbsr25 1014 6 ) ) -RRB- cord-024189-t7mbsr25 1014 7 is be VBZ cord-024189-t7mbsr25 1014 8 the the DT cord-024189-t7mbsr25 1014 9 most most RBS cord-024189-t7mbsr25 1014 10 common common JJ cord-024189-t7mbsr25 1014 11 large large JJ cord-024189-t7mbsr25 1014 12 vascular vascular JJ cord-024189-t7mbsr25 1014 13 lesion lesion NN cord-024189-t7mbsr25 1014 14 . . . cord-024189-t7mbsr25 1015 1 Patients patient NNS cord-024189-t7mbsr25 1015 2 with with IN cord-024189-t7mbsr25 1015 3 recurrent recurrent JJ cord-024189-t7mbsr25 1015 4 DVTs dvt NNS cord-024189-t7mbsr25 1015 5 are be VBP cord-024189-t7mbsr25 1015 6 at at IN cord-024189-t7mbsr25 1015 7 risk risk NN cord-024189-t7mbsr25 1015 8 for for IN cord-024189-t7mbsr25 1015 9 chronic chronic JJ cord-024189-t7mbsr25 1015 10 stasis stasis NN cord-024189-t7mbsr25 1015 11 changes change NNS cord-024189-t7mbsr25 1015 12 in in IN cord-024189-t7mbsr25 1015 13 the the DT cord-024189-t7mbsr25 1015 14 legs leg NNS cord-024189-t7mbsr25 1015 15 . . . cord-024189-t7mbsr25 1016 1 Occlusions Occlusions NNP cord-024189-t7mbsr25 1016 2 of of IN cord-024189-t7mbsr25 1016 3 the the DT cord-024189-t7mbsr25 1016 4 vena vena FW cord-024189-t7mbsr25 1016 5 cava cava NNP cord-024189-t7mbsr25 1016 6 , , , cord-024189-t7mbsr25 1016 7 hepatic hepatic JJ cord-024189-t7mbsr25 1016 8 , , , cord-024189-t7mbsr25 1016 9 and and CC cord-024189-t7mbsr25 1016 10 portal portal JJ cord-024189-t7mbsr25 1016 11 veins vein NNS cord-024189-t7mbsr25 1016 12 , , , cord-024189-t7mbsr25 1016 13 other other JJ cord-024189-t7mbsr25 1016 14 recognized recognize VBN cord-024189-t7mbsr25 1016 15 thrombotic thrombotic JJ cord-024189-t7mbsr25 1016 16 complications complication NNS cord-024189-t7mbsr25 1016 17 in in IN cord-024189-t7mbsr25 1016 18 BD BD NNP cord-024189-t7mbsr25 1016 19 , , , cord-024189-t7mbsr25 1016 20 are be VBP cord-024189-t7mbsr25 1016 21 associated associate VBN cord-024189-t7mbsr25 1016 22 with with IN cord-024189-t7mbsr25 1016 23 an an DT cord-024189-t7mbsr25 1016 24 increased increase VBN cord-024189-t7mbsr25 1016 25 risk risk NN cord-024189-t7mbsr25 1016 26 of of IN cord-024189-t7mbsr25 1016 27 mortality mortality NN cord-024189-t7mbsr25 1016 28 . . . cord-024189-t7mbsr25 1017 1 Chest chest NN cord-024189-t7mbsr25 1017 2 wall wall NN cord-024189-t7mbsr25 1017 3 , , , cord-024189-t7mbsr25 1017 4 abdominal abdominal JJ cord-024189-t7mbsr25 1017 5 , , , cord-024189-t7mbsr25 1017 6 and and CC cord-024189-t7mbsr25 1017 7 esophageal esophageal JJ cord-024189-t7mbsr25 1017 8 varices varix NNS cord-024189-t7mbsr25 1017 9 may may MD cord-024189-t7mbsr25 1017 10 occur occur VB cord-024189-t7mbsr25 1017 11 from from IN cord-024189-t7mbsr25 1017 12 deep deep RB cord-024189-t7mbsr25 1017 13 - - HYPH cord-024189-t7mbsr25 1017 14 seated seated JJ cord-024189-t7mbsr25 1017 15 venous venous JJ cord-024189-t7mbsr25 1017 16 thrombosis thrombosis NN cord-024189-t7mbsr25 1017 17 . . . cord-024189-t7mbsr25 1018 1 Right right JJ cord-024189-t7mbsr25 1018 2 ventricular ventricular JJ cord-024189-t7mbsr25 1018 3 thrombi thrombi NNP cord-024189-t7mbsr25 1018 4 have have VBP cord-024189-t7mbsr25 1018 5 been be VBN cord-024189-t7mbsr25 1018 6 reported report VBN cord-024189-t7mbsr25 1018 7 , , , cord-024189-t7mbsr25 1018 8 usually usually RB cord-024189-t7mbsr25 1018 9 in in IN cord-024189-t7mbsr25 1018 10 association association NN cord-024189-t7mbsr25 1018 11 with with IN cord-024189-t7mbsr25 1018 12 pulmonary pulmonary JJ cord-024189-t7mbsr25 1018 13 vasculitis vasculitis NN cord-024189-t7mbsr25 1018 14 . . . cord-024189-t7mbsr25 1019 1 No no DT cord-024189-t7mbsr25 1019 2 primary primary JJ cord-024189-t7mbsr25 1019 3 abnormality abnormality NN cord-024189-t7mbsr25 1019 4 of of IN cord-024189-t7mbsr25 1019 5 the the DT cord-024189-t7mbsr25 1019 6 coagulation coagulation NN cord-024189-t7mbsr25 1019 7 , , , cord-024189-t7mbsr25 1019 8 anticoagulation anticoagulation NN cord-024189-t7mbsr25 1019 9 , , , cord-024189-t7mbsr25 1019 10 or or CC cord-024189-t7mbsr25 1019 11 fi fi NNP cord-024189-t7mbsr25 1019 12 brinolytic brinolytic NNP cord-024189-t7mbsr25 1019 13 system system NN cord-024189-t7mbsr25 1019 14 explaining explain VBG cord-024189-t7mbsr25 1019 15 the the DT cord-024189-t7mbsr25 1019 16 thrombotic thrombotic JJ cord-024189-t7mbsr25 1019 17 tendency tendency NN cord-024189-t7mbsr25 1019 18 in in IN cord-024189-t7mbsr25 1019 19 BD BD NNP cord-024189-t7mbsr25 1019 20 has have VBZ cord-024189-t7mbsr25 1019 21 been be VBN cord-024189-t7mbsr25 1019 22 identifi identifi VBN cord-024189-t7mbsr25 1019 23 ed ed NNP cord-024189-t7mbsr25 1019 24 consistently consistently RB cord-024189-t7mbsr25 1019 25 . . . cord-024189-t7mbsr25 1020 1 Arterial arterial JJ cord-024189-t7mbsr25 1020 2 complications complication NNS cord-024189-t7mbsr25 1020 3 occur occur VBP cord-024189-t7mbsr25 1020 4 in in IN cord-024189-t7mbsr25 1020 5 up up IN cord-024189-t7mbsr25 1020 6 to to TO cord-024189-t7mbsr25 1020 7 7 7 CD cord-024189-t7mbsr25 1020 8 % % NN cord-024189-t7mbsr25 1020 9 of of IN cord-024189-t7mbsr25 1020 10 patients patient NNS cord-024189-t7mbsr25 1020 11 with with IN cord-024189-t7mbsr25 1020 12 BD BD NNP cord-024189-t7mbsr25 1020 13 ( ( -LRB- cord-024189-t7mbsr25 1020 14 5 5 CD cord-024189-t7mbsr25 1020 15 ) ) -RRB- cord-024189-t7mbsr25 1020 16 . . . cord-024189-t7mbsr25 1021 1 Stenoses stenosis NNS cord-024189-t7mbsr25 1021 2 , , , cord-024189-t7mbsr25 1021 3 occlusions occlusion NNS cord-024189-t7mbsr25 1021 4 , , , cord-024189-t7mbsr25 1021 5 and and CC cord-024189-t7mbsr25 1021 6 aneurysms aneurysm NNS cord-024189-t7mbsr25 1021 7 occur occur VBP cord-024189-t7mbsr25 1021 8 in in IN cord-024189-t7mbsr25 1021 9 the the DT cord-024189-t7mbsr25 1021 10 systemic systemic JJ cord-024189-t7mbsr25 1021 11 circulation circulation NN cord-024189-t7mbsr25 1021 12 or or CC cord-024189-t7mbsr25 1021 13 the the DT cord-024189-t7mbsr25 1021 14 pulmonary pulmonary JJ cord-024189-t7mbsr25 1021 15 arterial arterial JJ cord-024189-t7mbsr25 1021 16 bed bed NN cord-024189-t7mbsr25 1021 17 . . . cord-024189-t7mbsr25 1022 1 Arterial arterial JJ cord-024189-t7mbsr25 1022 2 aneurysms aneurysm NNS cord-024189-t7mbsr25 1022 3 , , , cord-024189-t7mbsr25 1022 4 caused cause VBN cord-024189-t7mbsr25 1022 5 by by IN cord-024189-t7mbsr25 1022 6 vasculitis vasculitis NN cord-024189-t7mbsr25 1022 7 of of IN cord-024189-t7mbsr25 1022 8 the the DT cord-024189-t7mbsr25 1022 9 vasa vasa NNP cord-024189-t7mbsr25 1022 10 vasorum vasorum NNP cord-024189-t7mbsr25 1022 11 , , , cord-024189-t7mbsr25 1022 12 involve involve VBP cord-024189-t7mbsr25 1022 13 the the DT cord-024189-t7mbsr25 1022 14 aorta aorta NN cord-024189-t7mbsr25 1022 15 or or CC cord-024189-t7mbsr25 1022 16 its -PRON- PRP$ cord-024189-t7mbsr25 1022 17 branches branch NNS cord-024189-t7mbsr25 1022 18 . . . cord-024189-t7mbsr25 1023 1 The the DT cord-024189-t7mbsr25 1023 2 risk risk NN cord-024189-t7mbsr25 1023 3 of of IN cord-024189-t7mbsr25 1023 4 rupture rupture NN cord-024189-t7mbsr25 1023 5 is be VBZ cord-024189-t7mbsr25 1023 6 high high JJ cord-024189-t7mbsr25 1023 7 . . . cord-024189-t7mbsr25 1024 1 Pulmonary pulmonary JJ cord-024189-t7mbsr25 1024 2 artery artery NN cord-024189-t7mbsr25 1024 3 aneurysms aneurysm NNS cord-024189-t7mbsr25 1024 4 ( ( -LRB- cord-024189-t7mbsr25 1024 5 6 6 CD cord-024189-t7mbsr25 1024 6 ) ) -RRB- cord-024189-t7mbsr25 1024 7 may may MD cord-024189-t7mbsr25 1024 8 lead lead VB cord-024189-t7mbsr25 1024 9 to to IN cord-024189-t7mbsr25 1024 10 fi fi NNP cord-024189-t7mbsr25 1024 11 stulae stulae NNS cord-024189-t7mbsr25 1024 12 between between IN cord-024189-t7mbsr25 1024 13 the the DT cord-024189-t7mbsr25 1024 14 pulmonary pulmonary JJ cord-024189-t7mbsr25 1024 15 artery artery NN cord-024189-t7mbsr25 1024 16 and and CC cord-024189-t7mbsr25 1024 17 bronchi bronchi NN cord-024189-t7mbsr25 1024 18 , , , cord-024189-t7mbsr25 1024 19 presenting present VBG cord-024189-t7mbsr25 1024 20 with with IN cord-024189-t7mbsr25 1024 21 hemoptysis hemoptysis NN cord-024189-t7mbsr25 1024 22 . . . cord-024189-t7mbsr25 1025 1 Anticoagulant anticoagulant JJ cord-024189-t7mbsr25 1025 2 treatment treatment NN cord-024189-t7mbsr25 1025 3 for for IN cord-024189-t7mbsr25 1025 4 presumed presume VBN cord-024189-t7mbsr25 1025 5 pulmonary pulmonary JJ cord-024189-t7mbsr25 1025 6 emboli emboli NN cord-024189-t7mbsr25 1025 7 can can MD cord-024189-t7mbsr25 1025 8 result result VB cord-024189-t7mbsr25 1025 9 in in IN cord-024189-t7mbsr25 1025 10 massive massive JJ cord-024189-t7mbsr25 1025 11 hemorrhage hemorrhage NN cord-024189-t7mbsr25 1025 12 and and CC cord-024189-t7mbsr25 1025 13 death death NN cord-024189-t7mbsr25 1025 14 . . . cord-024189-t7mbsr25 1026 1 Clinically clinically RB cord-024189-t7mbsr25 1026 2 apparent apparent JJ cord-024189-t7mbsr25 1026 3 cardiac cardiac JJ cord-024189-t7mbsr25 1026 4 vascular vascular JJ cord-024189-t7mbsr25 1026 5 involvement involvement NN cord-024189-t7mbsr25 1026 6 is be VBZ cord-024189-t7mbsr25 1026 7 unusual unusual JJ cord-024189-t7mbsr25 1026 8 , , , cord-024189-t7mbsr25 1026 9 but but CC cord-024189-t7mbsr25 1026 10 may may MD cord-024189-t7mbsr25 1026 11 result result VB cord-024189-t7mbsr25 1026 12 in in IN cord-024189-t7mbsr25 1026 13 myocardial myocardial JJ cord-024189-t7mbsr25 1026 14 infarction infarction NN cord-024189-t7mbsr25 1026 15 . . . cord-024189-t7mbsr25 1027 1 Gastrointestinal gastrointestinal JJ cord-024189-t7mbsr25 1027 2 symptoms symptom NNS cord-024189-t7mbsr25 1027 3 in in IN cord-024189-t7mbsr25 1027 4 BD BD NNP cord-024189-t7mbsr25 1027 5 include include VBP cord-024189-t7mbsr25 1027 6 melena melena NN cord-024189-t7mbsr25 1027 7 and and CC cord-024189-t7mbsr25 1027 8 abdominal abdominal JJ cord-024189-t7mbsr25 1027 9 pain pain NN cord-024189-t7mbsr25 1027 10 . . . cord-024189-t7mbsr25 1028 1 Colonoscopic colonoscopic JJ cord-024189-t7mbsr25 1028 2 lesions lesion NNS cord-024189-t7mbsr25 1028 3 appear appear VBP cord-024189-t7mbsr25 1028 4 as as IN cord-024189-t7mbsr25 1028 5 single single JJ cord-024189-t7mbsr25 1028 6 or or CC cord-024189-t7mbsr25 1028 7 multiple multiple JJ cord-024189-t7mbsr25 1028 8 ulcerations ulceration NNS cord-024189-t7mbsr25 1028 9 involving involve VBG cord-024189-t7mbsr25 1028 10 primarily primarily RB cord-024189-t7mbsr25 1028 11 the the DT cord-024189-t7mbsr25 1028 12 distal distal JJ cord-024189-t7mbsr25 1028 13 ileum ileum NN cord-024189-t7mbsr25 1028 14 and and CC cord-024189-t7mbsr25 1028 15 cecum cecum NN cord-024189-t7mbsr25 1028 16 . . . cord-024189-t7mbsr25 1029 1 Gastrointestinal gastrointestinal JJ cord-024189-t7mbsr25 1029 2 lesions lesion NNS cord-024189-t7mbsr25 1029 3 have have VBP cord-024189-t7mbsr25 1029 4 a a DT cord-024189-t7mbsr25 1029 5 tendency tendency NN cord-024189-t7mbsr25 1029 6 to to TO cord-024189-t7mbsr25 1029 7 perforate perforate VB cord-024189-t7mbsr25 1029 8 or or CC cord-024189-t7mbsr25 1029 9 to to TO cord-024189-t7mbsr25 1029 10 bleed bleed VB cord-024189-t7mbsr25 1029 11 . . . cord-024189-t7mbsr25 1030 1 The the DT cord-024189-t7mbsr25 1030 2 lesions lesion NNS cord-024189-t7mbsr25 1030 3 in in IN cord-024189-t7mbsr25 1030 4 BD BD NNP cord-024189-t7mbsr25 1030 5 should should MD cord-024189-t7mbsr25 1030 6 be be VB cord-024189-t7mbsr25 1030 7 differentiated differentiate VBN cord-024189-t7mbsr25 1030 8 from from IN cord-024189-t7mbsr25 1030 9 those those DT cord-024189-t7mbsr25 1030 10 of of IN cord-024189-t7mbsr25 1030 11 Crohn Crohn NNP cord-024189-t7mbsr25 1030 12 's 's POS cord-024189-t7mbsr25 1030 13 disease disease NN cord-024189-t7mbsr25 1030 14 and and CC cord-024189-t7mbsr25 1030 15 those those DT cord-024189-t7mbsr25 1030 16 due due JJ cord-024189-t7mbsr25 1030 17 to to IN cord-024189-t7mbsr25 1030 18 the the DT cord-024189-t7mbsr25 1030 19 use use NN cord-024189-t7mbsr25 1030 20 of of IN cord-024189-t7mbsr25 1030 21 nonsteroidal nonsteroidal JJ cord-024189-t7mbsr25 1030 22 antiinfl antiinfl NN cord-024189-t7mbsr25 1030 23 ammatory ammatory NNP cord-024189-t7mbsr25 1030 24 drugs drug NNS cord-024189-t7mbsr25 1030 25 . . . cord-024189-t7mbsr25 1031 1 An an DT cord-024189-t7mbsr25 1031 2 intermittent intermittent JJ cord-024189-t7mbsr25 1031 3 , , , cord-024189-t7mbsr25 1031 4 symmetric symmetric JJ cord-024189-t7mbsr25 1031 5 oligoarthritis oligoarthritis NN cord-024189-t7mbsr25 1031 6 of of IN cord-024189-t7mbsr25 1031 7 the the DT cord-024189-t7mbsr25 1031 8 knees knee NNS cord-024189-t7mbsr25 1031 9 , , , cord-024189-t7mbsr25 1031 10 ankles ankle NNS cord-024189-t7mbsr25 1031 11 , , , cord-024189-t7mbsr25 1031 12 hands hand NNS cord-024189-t7mbsr25 1031 13 , , , cord-024189-t7mbsr25 1031 14 or or CC cord-024189-t7mbsr25 1031 15 wrists wrist NNS cord-024189-t7mbsr25 1031 16 affects affect VBZ cord-024189-t7mbsr25 1031 17 one one CD cord-024189-t7mbsr25 1031 18 half half NN cord-024189-t7mbsr25 1031 19 of of IN cord-024189-t7mbsr25 1031 20 the the DT cord-024189-t7mbsr25 1031 21 patients patient NNS cord-024189-t7mbsr25 1031 22 with with IN cord-024189-t7mbsr25 1031 23 BD BD NNP cord-024189-t7mbsr25 1031 24 ; ; : cord-024189-t7mbsr25 1031 25 arthralgia arthralgia NNP cord-024189-t7mbsr25 1031 26 is be VBZ cord-024189-t7mbsr25 1031 27 also also RB cord-024189-t7mbsr25 1031 28 common common JJ cord-024189-t7mbsr25 1031 29 . . . cord-024189-t7mbsr25 1032 1 An an DT cord-024189-t7mbsr25 1032 2 erosive erosive JJ cord-024189-t7mbsr25 1032 3 or or CC cord-024189-t7mbsr25 1032 4 destructive destructive JJ cord-024189-t7mbsr25 1032 5 arthropathy arthropathy NN cord-024189-t7mbsr25 1032 6 is be VBZ cord-024189-t7mbsr25 1032 7 unusual unusual JJ cord-024189-t7mbsr25 1032 8 . . . cord-024189-t7mbsr25 1033 1 Infl Infl NNP cord-024189-t7mbsr25 1033 2 ammatory ammatory NN cord-024189-t7mbsr25 1033 3 cells cell NNS cord-024189-t7mbsr25 1033 4 of of IN cord-024189-t7mbsr25 1033 5 the the DT cord-024189-t7mbsr25 1033 6 synovium synovium JJ cord-024189-t7mbsr25 1033 7 and and CC cord-024189-t7mbsr25 1033 8 synovial synovial JJ cord-024189-t7mbsr25 1033 9 fl fl NNP cord-024189-t7mbsr25 1033 10 uid uid NN cord-024189-t7mbsr25 1033 11 are be VBP cord-024189-t7mbsr25 1033 12 primarily primarily RB cord-024189-t7mbsr25 1033 13 polymorphonuclear polymorphonuclear JJ cord-024189-t7mbsr25 1033 14 leukocytes leukocyte NNS cord-024189-t7mbsr25 1033 15 . . . cord-024189-t7mbsr25 1034 1 Epididymitis epididymitis NN cord-024189-t7mbsr25 1034 2 occurs occur VBZ cord-024189-t7mbsr25 1034 3 in in IN cord-024189-t7mbsr25 1034 4 about about RB cord-024189-t7mbsr25 1034 5 5 5 CD cord-024189-t7mbsr25 1034 6 % % NN cord-024189-t7mbsr25 1034 7 of of IN cord-024189-t7mbsr25 1034 8 affected affected JJ cord-024189-t7mbsr25 1034 9 patients patient NNS cord-024189-t7mbsr25 1034 10 . . . cord-024189-t7mbsr25 1035 1 Glomerulonephritis glomerulonephritis JJ cord-024189-t7mbsr25 1035 2 and and CC cord-024189-t7mbsr25 1035 3 peripheral peripheral JJ cord-024189-t7mbsr25 1035 4 neuropathy neuropathy NN cord-024189-t7mbsr25 1035 5 occur occur VBP cord-024189-t7mbsr25 1035 6 much much RB cord-024189-t7mbsr25 1035 7 less less RBR cord-024189-t7mbsr25 1035 8 frequently frequently RB cord-024189-t7mbsr25 1035 9 in in IN cord-024189-t7mbsr25 1035 10 BD BD NNP cord-024189-t7mbsr25 1035 11 than than IN cord-024189-t7mbsr25 1035 12 in in IN cord-024189-t7mbsr25 1035 13 other other JJ cord-024189-t7mbsr25 1035 14 forms form NNS cord-024189-t7mbsr25 1035 15 of of IN cord-024189-t7mbsr25 1035 16 systemic systemic JJ cord-024189-t7mbsr25 1035 17 vasculitis vasculitis NN cord-024189-t7mbsr25 1035 18 . . . cord-024189-t7mbsr25 1036 1 AA aa NN cord-024189-t7mbsr25 1036 2 - - HYPH cord-024189-t7mbsr25 1036 3 type type NN cord-024189-t7mbsr25 1036 4 amyloidosis amyloidosis NN cord-024189-t7mbsr25 1036 5 , , , cord-024189-t7mbsr25 1036 6 presenting present VBG cord-024189-t7mbsr25 1036 7 as as IN cord-024189-t7mbsr25 1036 8 nephrotic nephrotic JJ cord-024189-t7mbsr25 1036 9 syndrome syndrome NN cord-024189-t7mbsr25 1036 10 , , , cord-024189-t7mbsr25 1036 11 can can MD cord-024189-t7mbsr25 1036 12 accompany accompany VB cord-024189-t7mbsr25 1036 13 BD BD NNP cord-024189-t7mbsr25 1036 14 . . . cord-024189-t7mbsr25 1037 1 The the DT cord-024189-t7mbsr25 1037 2 occasional occasional JJ cord-024189-t7mbsr25 1037 3 association association NN cord-024189-t7mbsr25 1037 4 of of IN cord-024189-t7mbsr25 1037 5 the the DT cord-024189-t7mbsr25 1037 6 disorder disorder NN cord-024189-t7mbsr25 1037 7 with with IN cord-024189-t7mbsr25 1037 8 ankylosing ankylose VBG cord-024189-t7mbsr25 1037 9 spondylitis spondylitis NN cord-024189-t7mbsr25 1037 10 [ [ -LRB- cord-024189-t7mbsr25 1037 11 in in IN cord-024189-t7mbsr25 1037 12 human human JJ cord-024189-t7mbsr25 1037 13 leukocyte leukocyte NN cord-024189-t7mbsr25 1037 14 antigen antigen NN cord-024189-t7mbsr25 1037 15 ( ( -LRB- cord-024189-t7mbsr25 1037 16 HLA)-B27-positive hla)-b27-positive CD cord-024189-t7mbsr25 1037 17 patients patient NNS cord-024189-t7mbsr25 1037 18 ] ] -RRB- cord-024189-t7mbsr25 1037 19 or or CC cord-024189-t7mbsr25 1037 20 relapsing relapse VBG cord-024189-t7mbsr25 1037 21 polychondritis polychondritis NN cord-024189-t7mbsr25 1037 22 ( ( -LRB- cord-024189-t7mbsr25 1037 23 MAGIC magic NN cord-024189-t7mbsr25 1037 24 syn syn NN cord-024189-t7mbsr25 1037 25 - - HYPH cord-024189-t7mbsr25 1037 26 drome drome NN cord-024189-t7mbsr25 1037 27 [ [ -LRB- cord-024189-t7mbsr25 1037 28 mouth mouth NN cord-024189-t7mbsr25 1037 29 and and CC cord-024189-t7mbsr25 1037 30 genital genital JJ cord-024189-t7mbsr25 1037 31 ulcers ulcer NNS cord-024189-t7mbsr25 1037 32 with with IN cord-024189-t7mbsr25 1037 33 infl infl NNP cord-024189-t7mbsr25 1037 34 amed amed NNP cord-024189-t7mbsr25 1037 35 cartilage cartilage NNP cord-024189-t7mbsr25 1037 36 ] ] -RRB- cord-024189-t7mbsr25 1037 37 ) ) -RRB- cord-024189-t7mbsr25 1038 1 likely likely RB cord-024189-t7mbsr25 1038 2 represents represent VBZ cord-024189-t7mbsr25 1038 3 the the DT cord-024189-t7mbsr25 1038 4 simultaneous simultaneous JJ cord-024189-t7mbsr25 1038 5 occurrence occurrence NN cord-024189-t7mbsr25 1038 6 of of IN cord-024189-t7mbsr25 1038 7 two two CD cord-024189-t7mbsr25 1038 8 disorders disorder NNS cord-024189-t7mbsr25 1038 9 . . . cord-024189-t7mbsr25 1039 1 No no DT cord-024189-t7mbsr25 1039 2 laboratory laboratory NN cord-024189-t7mbsr25 1039 3 abnormality abnormality NN cord-024189-t7mbsr25 1039 4 is be VBZ cord-024189-t7mbsr25 1039 5 diagnostic diagnostic JJ cord-024189-t7mbsr25 1039 6 of of IN cord-024189-t7mbsr25 1039 7 BD BD NNP cord-024189-t7mbsr25 1039 8 . . . cord-024189-t7mbsr25 1040 1 Acute acute JJ cord-024189-t7mbsr25 1040 2 - - HYPH cord-024189-t7mbsr25 1040 3 phase phase NN cord-024189-t7mbsr25 1040 4 reactants reactant NNS cord-024189-t7mbsr25 1040 5 may may MD cord-024189-t7mbsr25 1040 6 be be VB cord-024189-t7mbsr25 1040 7 increased increase VBN cord-024189-t7mbsr25 1040 8 , , , cord-024189-t7mbsr25 1040 9 especially especially RB cord-024189-t7mbsr25 1040 10 in in IN cord-024189-t7mbsr25 1040 11 patients patient NNS cord-024189-t7mbsr25 1040 12 with with IN cord-024189-t7mbsr25 1040 13 large large JJ cord-024189-t7mbsr25 1040 14 vessel vessel NN cord-024189-t7mbsr25 1040 15 vasculitis vasculitis NN cord-024189-t7mbsr25 1040 16 , , , cord-024189-t7mbsr25 1040 17 but but CC cord-024189-t7mbsr25 1040 18 they -PRON- PRP cord-024189-t7mbsr25 1040 19 may may MD cord-024189-t7mbsr25 1040 20 be be VB cord-024189-t7mbsr25 1040 21 normal normal JJ cord-024189-t7mbsr25 1040 22 in in IN cord-024189-t7mbsr25 1040 23 other other JJ cord-024189-t7mbsr25 1040 24 patients patient NNS cord-024189-t7mbsr25 1040 25 , , , cord-024189-t7mbsr25 1040 26 even even RB cord-024189-t7mbsr25 1040 27 those those DT cord-024189-t7mbsr25 1040 28 with with IN cord-024189-t7mbsr25 1040 29 active active JJ cord-024189-t7mbsr25 1040 30 eye eye NN cord-024189-t7mbsr25 1040 31 disease disease NN cord-024189-t7mbsr25 1040 32 . . . cord-024189-t7mbsr25 1041 1 The the DT cord-024189-t7mbsr25 1041 2 histocompatibility histocompatibility NN cord-024189-t7mbsr25 1041 3 antigen antigen NN cord-024189-t7mbsr25 1041 4 HLA HLA NNP cord-024189-t7mbsr25 1041 5 - - HYPH cord-024189-t7mbsr25 1041 6 B51 B51 NNP cord-024189-t7mbsr25 1041 7 is be VBZ cord-024189-t7mbsr25 1041 8 associated associate VBN cord-024189-t7mbsr25 1041 9 with with IN cord-024189-t7mbsr25 1041 10 BD BD NNP cord-024189-t7mbsr25 1041 11 in in IN cord-024189-t7mbsr25 1041 12 areas area NNS cord-024189-t7mbsr25 1041 13 of of IN cord-024189-t7mbsr25 1041 14 high high JJ cord-024189-t7mbsr25 1041 15 prevalence prevalence NN cord-024189-t7mbsr25 1041 16 and and CC cord-024189-t7mbsr25 1041 17 in in IN cord-024189-t7mbsr25 1041 18 patients patient NNS cord-024189-t7mbsr25 1041 19 with with IN cord-024189-t7mbsr25 1041 20 ocular ocular JJ cord-024189-t7mbsr25 1041 21 disease disease NN cord-024189-t7mbsr25 1041 22 . . . cord-024189-t7mbsr25 1042 1 The the DT cord-024189-t7mbsr25 1042 2 multiple multiple JJ cord-024189-t7mbsr25 1042 3 manifestations manifestation NNS cord-024189-t7mbsr25 1042 4 of of IN cord-024189-t7mbsr25 1042 5 BD BD NNP cord-024189-t7mbsr25 1042 6 in in IN cord-024189-t7mbsr25 1042 7 the the DT cord-024189-t7mbsr25 1042 8 same same JJ cord-024189-t7mbsr25 1042 9 patient patient NN cord-024189-t7mbsr25 1042 10 may may MD cord-024189-t7mbsr25 1042 11 be be VB cord-024189-t7mbsr25 1042 12 separated separate VBN cord-024189-t7mbsr25 1042 13 in in IN cord-024189-t7mbsr25 1042 14 time time NN cord-024189-t7mbsr25 1042 15 , , , cord-024189-t7mbsr25 1042 16 occasionally occasionally RB cord-024189-t7mbsr25 1042 17 by by IN cord-024189-t7mbsr25 1042 18 several several JJ cord-024189-t7mbsr25 1042 19 years year NNS cord-024189-t7mbsr25 1042 20 . . . cord-024189-t7mbsr25 1043 1 For for IN cord-024189-t7mbsr25 1043 2 defi defi NNP cord-024189-t7mbsr25 1043 3 nitive nitive NNP cord-024189-t7mbsr25 1043 4 diagnosis diagnosis NN cord-024189-t7mbsr25 1043 5 , , , cord-024189-t7mbsr25 1043 6 the the DT cord-024189-t7mbsr25 1043 7 manifestations manifestation NNS cord-024189-t7mbsr25 1043 8 must must MD cord-024189-t7mbsr25 1043 9 be be VB cord-024189-t7mbsr25 1043 10 documented document VBN cord-024189-t7mbsr25 1043 11 or or CC cord-024189-t7mbsr25 1043 12 witnessed witness VBN cord-024189-t7mbsr25 1043 13 by by IN cord-024189-t7mbsr25 1043 14 a a DT cord-024189-t7mbsr25 1043 15 physician physician NN cord-024189-t7mbsr25 1043 16 . . . cord-024189-t7mbsr25 1044 1 The the DT cord-024189-t7mbsr25 1044 2 ISG ISG NNP cord-024189-t7mbsr25 1044 3 criteria criterion NNS cord-024189-t7mbsr25 1044 4 for for IN cord-024189-t7mbsr25 1044 5 the the DT cord-024189-t7mbsr25 1044 6 classifi classifi NNP cord-024189-t7mbsr25 1044 7 cation cation NN cord-024189-t7mbsr25 1044 8 of of IN cord-024189-t7mbsr25 1044 9 BD BD NNP cord-024189-t7mbsr25 1045 1 ( ( -LRB- cord-024189-t7mbsr25 1045 2 Table table NN cord-024189-t7mbsr25 1045 3 21E- 21e- CD cord-024189-t7mbsr25 1045 4 Infl Infl NNP cord-024189-t7mbsr25 1045 5 ammatory ammatory NN cord-024189-t7mbsr25 1045 6 bowel bowel NN cord-024189-t7mbsr25 1045 7 disease disease NN cord-024189-t7mbsr25 1045 8 , , , cord-024189-t7mbsr25 1045 9 sprue sprue NN cord-024189-t7mbsr25 1045 10 , , , cord-024189-t7mbsr25 1045 11 cyclic cyclic JJ cord-024189-t7mbsr25 1045 12 neutropenia neutropenia NNS cord-024189-t7mbsr25 1045 13 or or CC cord-024189-t7mbsr25 1045 14 other other JJ cord-024189-t7mbsr25 1045 15 hematologic hematologic JJ cord-024189-t7mbsr25 1045 16 disorders disorder NNS cord-024189-t7mbsr25 1045 17 , , , cord-024189-t7mbsr25 1045 18 herpes herpes NN cord-024189-t7mbsr25 1045 19 simplex simplex NN cord-024189-t7mbsr25 1045 20 infection infection NN cord-024189-t7mbsr25 1045 21 , , , cord-024189-t7mbsr25 1045 22 and and CC cord-024189-t7mbsr25 1045 23 acquired acquire VBD cord-024189-t7mbsr25 1045 24 immune immune JJ cord-024189-t7mbsr25 1045 25 defi defi NNP cord-024189-t7mbsr25 1045 26 ciency ciency NNP cord-024189-t7mbsr25 1045 27 syndrome syndrome NN cord-024189-t7mbsr25 1045 28 may may MD cord-024189-t7mbsr25 1045 29 cause cause VB cord-024189-t7mbsr25 1045 30 similar similar JJ cord-024189-t7mbsr25 1045 31 lesions lesion NNS cord-024189-t7mbsr25 1045 32 . . . cord-024189-t7mbsr25 1046 1 Other other JJ cord-024189-t7mbsr25 1046 2 disorders disorder NNS cord-024189-t7mbsr25 1046 3 responsible responsible JJ cord-024189-t7mbsr25 1046 4 for for IN cord-024189-t7mbsr25 1046 5 orogenital orogenital JJ cord-024189-t7mbsr25 1046 6 / / SYM cord-024189-t7mbsr25 1046 7 ocular ocular JJ cord-024189-t7mbsr25 1046 8 syndromes syndrome NNS cord-024189-t7mbsr25 1046 9 include include VBP cord-024189-t7mbsr25 1046 10 erythema erythema NN cord-024189-t7mbsr25 1046 11 multiforme multiforme NN cord-024189-t7mbsr25 1046 12 , , , cord-024189-t7mbsr25 1046 13 mucous mucous JJ cord-024189-t7mbsr25 1046 14 membrane membrane NN cord-024189-t7mbsr25 1046 15 pemphigoid pemphigoid NNP cord-024189-t7mbsr25 1046 16 , , , cord-024189-t7mbsr25 1046 17 and and CC cord-024189-t7mbsr25 1046 18 the the DT cord-024189-t7mbsr25 1046 19 vulvovaginal vulvovaginal JJ cord-024189-t7mbsr25 1046 20 - - HYPH cord-024189-t7mbsr25 1046 21 gingival gingival NN cord-024189-t7mbsr25 1046 22 form form NN cord-024189-t7mbsr25 1046 23 of of IN cord-024189-t7mbsr25 1046 24 erosive erosive JJ cord-024189-t7mbsr25 1046 25 lichen lichen NN cord-024189-t7mbsr25 1046 26 planus planus NN cord-024189-t7mbsr25 1046 27 . . . cord-024189-t7mbsr25 1047 1 The the DT cord-024189-t7mbsr25 1047 2 differential differential JJ cord-024189-t7mbsr25 1047 3 diagnosis diagnosis NN cord-024189-t7mbsr25 1047 4 can can MD cord-024189-t7mbsr25 1047 5 be be VB cord-024189-t7mbsr25 1047 6 clarifi clarifi VBN cord-024189-t7mbsr25 1047 7 ed ed NN cord-024189-t7mbsr25 1047 8 with with IN cord-024189-t7mbsr25 1047 9 the the DT cord-024189-t7mbsr25 1047 10 aid aid NN cord-024189-t7mbsr25 1047 11 of of IN cord-024189-t7mbsr25 1047 12 an an DT cord-024189-t7mbsr25 1047 13 experienced experienced JJ cord-024189-t7mbsr25 1047 14 dermatologist dermatologist NN cord-024189-t7mbsr25 1047 15 and and CC cord-024189-t7mbsr25 1047 16 biopsy biopsy NN cord-024189-t7mbsr25 1047 17 fi fi NN cord-024189-t7mbsr25 1047 18 ndings nding NNS cord-024189-t7mbsr25 1047 19 . . . cord-024189-t7mbsr25 1048 1 In in IN cord-024189-t7mbsr25 1048 2 Reiter Reiter NNP cord-024189-t7mbsr25 1048 3 's 's POS cord-024189-t7mbsr25 1048 4 disease disease NN cord-024189-t7mbsr25 1048 5 , , , cord-024189-t7mbsr25 1048 6 mucocutaneous mucocutaneous JJ cord-024189-t7mbsr25 1048 7 lesions lesion NNS cord-024189-t7mbsr25 1048 8 are be VBP cord-024189-t7mbsr25 1048 9 nonulcerative nonulcerative JJ cord-024189-t7mbsr25 1048 10 and and CC cord-024189-t7mbsr25 1048 11 painless painless JJ cord-024189-t7mbsr25 1048 12 , , , cord-024189-t7mbsr25 1048 13 and and CC cord-024189-t7mbsr25 1048 14 the the DT cord-024189-t7mbsr25 1048 15 uveitis uveitis NN cord-024189-t7mbsr25 1048 16 is be VBZ cord-024189-t7mbsr25 1048 17 usually usually RB cord-024189-t7mbsr25 1048 18 limited limit VBN cord-024189-t7mbsr25 1048 19 to to IN cord-024189-t7mbsr25 1048 20 the the DT cord-024189-t7mbsr25 1048 21 anterior anterior NNP cord-024189-t7mbsr25 1048 22 chamber chamber NN cord-024189-t7mbsr25 1048 23 . . . cord-024189-t7mbsr25 1049 1 Similarities similarity NNS cord-024189-t7mbsr25 1049 2 between between IN cord-024189-t7mbsr25 1049 3 BD BD NNP cord-024189-t7mbsr25 1049 4 and and CC cord-024189-t7mbsr25 1049 5 Crohn Crohn NNP cord-024189-t7mbsr25 1049 6 's 's POS cord-024189-t7mbsr25 1049 7 disease disease NN cord-024189-t7mbsr25 1049 8 include include VBP cord-024189-t7mbsr25 1049 9 gastrointestinal gastrointestinal JJ cord-024189-t7mbsr25 1049 10 lesions lesion NNS cord-024189-t7mbsr25 1049 11 , , , cord-024189-t7mbsr25 1049 12 fever fever NN cord-024189-t7mbsr25 1049 13 , , , cord-024189-t7mbsr25 1049 14 anemia anemia NN cord-024189-t7mbsr25 1049 15 , , , cord-024189-t7mbsr25 1049 16 oral oral JJ cord-024189-t7mbsr25 1049 17 ulcers ulcer NNS cord-024189-t7mbsr25 1049 18 , , , cord-024189-t7mbsr25 1049 19 uveitis uveitis NN cord-024189-t7mbsr25 1049 20 , , , cord-024189-t7mbsr25 1049 21 arthritis arthritis NN cord-024189-t7mbsr25 1049 22 , , , cord-024189-t7mbsr25 1049 23 thrombophlebitis thrombophlebitis NNP cord-024189-t7mbsr25 1049 24 , , , cord-024189-t7mbsr25 1049 25 and and CC cord-024189-t7mbsr25 1049 26 erythema erythema NNP cord-024189-t7mbsr25 1049 27 nodosum nodosum NNP cord-024189-t7mbsr25 1049 28 . . . cord-024189-t7mbsr25 1050 1 Granuloma Granuloma NNP cord-024189-t7mbsr25 1050 2 formation formation NN cord-024189-t7mbsr25 1050 3 in in IN cord-024189-t7mbsr25 1050 4 intestinal intestinal JJ cord-024189-t7mbsr25 1050 5 lesions lesion NNS cord-024189-t7mbsr25 1050 6 is be VBZ cord-024189-t7mbsr25 1050 7 not not RB cord-024189-t7mbsr25 1050 8 typical typical JJ cord-024189-t7mbsr25 1050 9 in in IN cord-024189-t7mbsr25 1050 10 BD BD NNP cord-024189-t7mbsr25 1050 11 , , , cord-024189-t7mbsr25 1050 12 and and CC cord-024189-t7mbsr25 1050 13 in in IN cord-024189-t7mbsr25 1050 14 Crohn Crohn NNP cord-024189-t7mbsr25 1050 15 's 's POS cord-024189-t7mbsr25 1050 16 disease disease NN cord-024189-t7mbsr25 1050 17 the the DT cord-024189-t7mbsr25 1050 18 iritis iritis NN cord-024189-t7mbsr25 1050 19 is be VBZ cord-024189-t7mbsr25 1050 20 typically typically RB cord-024189-t7mbsr25 1050 21 confi confi VBN cord-024189-t7mbsr25 1050 22 ned ned NNP cord-024189-t7mbsr25 1050 23 to to IN cord-024189-t7mbsr25 1050 24 the the DT cord-024189-t7mbsr25 1050 25 anterior anterior NNP cord-024189-t7mbsr25 1050 26 chamber chamber NN cord-024189-t7mbsr25 1050 27 . . . cord-024189-t7mbsr25 1051 1 Genital genital JJ cord-024189-t7mbsr25 1051 2 ulcerations ulceration NNS cord-024189-t7mbsr25 1051 3 and and CC cord-024189-t7mbsr25 1051 4 central central JJ cord-024189-t7mbsr25 1051 5 nervous nervous JJ cord-024189-t7mbsr25 1051 6 system system NN cord-024189-t7mbsr25 1051 7 disease disease NN cord-024189-t7mbsr25 1051 8 are be VBP cord-024189-t7mbsr25 1051 9 rare rare JJ cord-024189-t7mbsr25 1051 10 in in IN cord-024189-t7mbsr25 1051 11 Crohn Crohn NNP cord-024189-t7mbsr25 1051 12 's 's POS cord-024189-t7mbsr25 1051 13 disease disease NN cord-024189-t7mbsr25 1051 14 . . . cord-024189-t7mbsr25 1052 1 Frequent frequent JJ cord-024189-t7mbsr25 1052 2 ophthalmologic ophthalmologic JJ cord-024189-t7mbsr25 1052 3 examinations examination NNS cord-024189-t7mbsr25 1052 4 are be VBP cord-024189-t7mbsr25 1052 5 essential essential JJ cord-024189-t7mbsr25 1052 6 for for IN cord-024189-t7mbsr25 1052 7 patients patient NNS cord-024189-t7mbsr25 1052 8 with with IN cord-024189-t7mbsr25 1052 9 ocular ocular JJ cord-024189-t7mbsr25 1052 10 disease disease NN cord-024189-t7mbsr25 1052 11 , , , cord-024189-t7mbsr25 1052 12 and and CC cord-024189-t7mbsr25 1052 13 periodic periodic JJ cord-024189-t7mbsr25 1052 14 monitoring monitoring NN cord-024189-t7mbsr25 1052 15 of of IN cord-024189-t7mbsr25 1052 16 the the DT cord-024189-t7mbsr25 1052 17 eyes eye NNS cord-024189-t7mbsr25 1052 18 is be VBZ cord-024189-t7mbsr25 1052 19 recommended recommend VBN cord-024189-t7mbsr25 1052 20 for for IN cord-024189-t7mbsr25 1052 21 all all DT cord-024189-t7mbsr25 1052 22 patients patient NNS cord-024189-t7mbsr25 1052 23 . . . cord-024189-t7mbsr25 1053 1 A a DT cord-024189-t7mbsr25 1053 2 careful careful JJ cord-024189-t7mbsr25 1053 3 history history NN cord-024189-t7mbsr25 1053 4 and and CC cord-024189-t7mbsr25 1053 5 examination examination NN cord-024189-t7mbsr25 1053 6 , , , cord-024189-t7mbsr25 1053 7 with with IN cord-024189-t7mbsr25 1053 8 attention attention NN cord-024189-t7mbsr25 1053 9 to to IN cord-024189-t7mbsr25 1053 10 the the DT cord-024189-t7mbsr25 1053 11 vascular vascular JJ cord-024189-t7mbsr25 1053 12 and and CC cord-024189-t7mbsr25 1053 13 neurologic neurologic JJ cord-024189-t7mbsr25 1053 14 systems system NNS cord-024189-t7mbsr25 1053 15 , , , cord-024189-t7mbsr25 1053 16 should should MD cord-024189-t7mbsr25 1053 17 be be VB cord-024189-t7mbsr25 1053 18 part part NN cord-024189-t7mbsr25 1053 19 of of IN cord-024189-t7mbsr25 1053 20 the the DT cord-024189-t7mbsr25 1053 21 physician physician NN cord-024189-t7mbsr25 1053 22 's 's POS cord-024189-t7mbsr25 1053 23 assessment assessment NN cord-024189-t7mbsr25 1053 24 . . . cord-024189-t7mbsr25 1054 1 Standardized standardized JJ cord-024189-t7mbsr25 1054 2 forms form NNS cord-024189-t7mbsr25 1054 3 for for IN cord-024189-t7mbsr25 1054 4 scoring score VBG cord-024189-t7mbsr25 1054 5 disease disease NN cord-024189-t7mbsr25 1054 6 activity activity NN cord-024189-t7mbsr25 1054 7 and and CC cord-024189-t7mbsr25 1054 8 ocular ocular JJ cord-024189-t7mbsr25 1054 9 infl infl NN cord-024189-t7mbsr25 1054 10 ammation ammation NNP cord-024189-t7mbsr25 1054 11 have have VBP cord-024189-t7mbsr25 1054 12 been be VBN cord-024189-t7mbsr25 1054 13 developed develop VBN cord-024189-t7mbsr25 1054 14 for for IN cord-024189-t7mbsr25 1054 15 use use NN cord-024189-t7mbsr25 1054 16 in in IN cord-024189-t7mbsr25 1054 17 clinical clinical JJ cord-024189-t7mbsr25 1054 18 trials trial NNS cord-024189-t7mbsr25 1054 19 and and CC cord-024189-t7mbsr25 1054 20 the the DT cord-024189-t7mbsr25 1054 21 care care NN cord-024189-t7mbsr25 1054 22 of of IN cord-024189-t7mbsr25 1054 23 individual individual JJ cord-024189-t7mbsr25 1054 24 patients patient NNS cord-024189-t7mbsr25 1054 25 ( ( -LRB- cord-024189-t7mbsr25 1054 26 8) 8) NNP cord-024189-t7mbsr25 1054 27 . . . cord-024189-t7mbsr25 1055 1 Aphthous Aphthous NNP cord-024189-t7mbsr25 1055 2 lesions lesion NNS cord-024189-t7mbsr25 1055 3 are be VBP cord-024189-t7mbsr25 1055 4 treated treat VBN cord-024189-t7mbsr25 1055 5 with with IN cord-024189-t7mbsr25 1055 6 topical topical JJ cord-024189-t7mbsr25 1055 7 or or CC cord-024189-t7mbsr25 1055 8 intralesional intralesional JJ cord-024189-t7mbsr25 1055 9 corticosteroids corticosteroid NNS cord-024189-t7mbsr25 1055 10 . . . cord-024189-t7mbsr25 1056 1 An an DT cord-024189-t7mbsr25 1056 2 empiric empiric JJ cord-024189-t7mbsr25 1056 3 trial trial NN cord-024189-t7mbsr25 1056 4 of of IN cord-024189-t7mbsr25 1056 5 dapsone dapsone NNP cord-024189-t7mbsr25 1056 6 or or CC cord-024189-t7mbsr25 1056 7 methotrexate methotrexate NNP cord-024189-t7mbsr25 1056 8 may may MD cord-024189-t7mbsr25 1056 9 be be VB cord-024189-t7mbsr25 1056 10 appropriate appropriate JJ cord-024189-t7mbsr25 1056 11 in in IN cord-024189-t7mbsr25 1056 12 diffi diffi JJ cord-024189-t7mbsr25 1056 13 cult cult NN cord-024189-t7mbsr25 1056 14 cases case NNS cord-024189-t7mbsr25 1056 15 . . . cord-024189-t7mbsr25 1057 1 Colchicine Colchicine NNP cord-024189-t7mbsr25 1057 2 is be VBZ cord-024189-t7mbsr25 1057 3 used use VBN cord-024189-t7mbsr25 1057 4 in in IN cord-024189-t7mbsr25 1057 5 the the DT cord-024189-t7mbsr25 1057 6 treatment treatment NN cord-024189-t7mbsr25 1057 7 of of IN cord-024189-t7mbsr25 1057 8 mucocutaneous mucocutaneous JJ cord-024189-t7mbsr25 1057 9 manifestations manifestation NNS cord-024189-t7mbsr25 1057 10 and and CC cord-024189-t7mbsr25 1057 11 as as IN cord-024189-t7mbsr25 1057 12 an an DT cord-024189-t7mbsr25 1057 13 adjunct adjunct NN cord-024189-t7mbsr25 1057 14 in in IN cord-024189-t7mbsr25 1057 15 the the DT cord-024189-t7mbsr25 1057 16 treatment treatment NN cord-024189-t7mbsr25 1057 17 of of IN cord-024189-t7mbsr25 1057 18 more more RBR cord-024189-t7mbsr25 1057 19 serious serious JJ cord-024189-t7mbsr25 1057 20 manifestations manifestation NNS cord-024189-t7mbsr25 1057 21 ( ( -LRB- cord-024189-t7mbsr25 1057 22 0.6 0.6 CD cord-024189-t7mbsr25 1057 23 mg mg CD cord-024189-t7mbsr25 1057 24 three three CD cord-024189-t7mbsr25 1057 25 times time NNS cord-024189-t7mbsr25 1057 26 daily daily RB cord-024189-t7mbsr25 1057 27 may may MD cord-024189-t7mbsr25 1057 28 be be VB cord-024189-t7mbsr25 1057 29 required require VBN cord-024189-t7mbsr25 1057 30 to to TO cord-024189-t7mbsr25 1057 31 achieve achieve VB cord-024189-t7mbsr25 1057 32 a a DT cord-024189-t7mbsr25 1057 33 therapeutic therapeutic JJ cord-024189-t7mbsr25 1057 34 effect effect NN cord-024189-t7mbsr25 1057 35 ; ; : cord-024189-t7mbsr25 1057 36 many many JJ cord-024189-t7mbsr25 1057 37 patients patient NNS cord-024189-t7mbsr25 1057 38 suffer suffer VBP cord-024189-t7mbsr25 1057 39 gastrointestinal gastrointestinal JJ cord-024189-t7mbsr25 1057 40 intolerance intolerance NN cord-024189-t7mbsr25 1057 41 of of IN cord-024189-t7mbsr25 1057 42 the the DT cord-024189-t7mbsr25 1057 43 drug drug NN cord-024189-t7mbsr25 1057 44 at at IN cord-024189-t7mbsr25 1057 45 that that DT cord-024189-t7mbsr25 1057 46 dose dose NN cord-024189-t7mbsr25 1057 47 ) ) -RRB- cord-024189-t7mbsr25 1057 48 . . . cord-024189-t7mbsr25 1058 1 The the DT cord-024189-t7mbsr25 1058 2 effectiveness effectiveness NN cord-024189-t7mbsr25 1058 3 of of IN cord-024189-t7mbsr25 1058 4 colchicine colchicine NNP cord-024189-t7mbsr25 1058 5 has have VBZ cord-024189-t7mbsr25 1058 6 been be VBN cord-024189-t7mbsr25 1058 7 demonstrated demonstrate VBN cord-024189-t7mbsr25 1058 8 for for IN cord-024189-t7mbsr25 1058 9 genital genital JJ cord-024189-t7mbsr25 1058 10 ulcers ulcer NNS cord-024189-t7mbsr25 1058 11 and and CC cord-024189-t7mbsr25 1058 12 erythema erythema NN cord-024189-t7mbsr25 1058 13 nodosum nodosum NN cord-024189-t7mbsr25 1058 14 in in IN cord-024189-t7mbsr25 1058 15 females female NNS cord-024189-t7mbsr25 1058 16 and and CC cord-024189-t7mbsr25 1058 17 for for IN cord-024189-t7mbsr25 1058 18 arthritis arthritis NN cord-024189-t7mbsr25 1058 19 in in IN cord-024189-t7mbsr25 1058 20 both both DT cord-024189-t7mbsr25 1058 21 sexes sex NNS cord-024189-t7mbsr25 1058 22 ( ( -LRB- cord-024189-t7mbsr25 1058 23 9 9 CD cord-024189-t7mbsr25 1058 24 ) ) -RRB- cord-024189-t7mbsr25 1058 25 . . . cord-024189-t7mbsr25 1059 1 Thalidomide Thalidomide NNP cord-024189-t7mbsr25 1059 2 has have VBZ cord-024189-t7mbsr25 1059 3 been be VBN cord-024189-t7mbsr25 1059 4 used use VBN cord-024189-t7mbsr25 1059 5 for for IN cord-024189-t7mbsr25 1059 6 the the DT cord-024189-t7mbsr25 1059 7 treatment treatment NN cord-024189-t7mbsr25 1059 8 of of IN cord-024189-t7mbsr25 1059 9 mucosal mucosal JJ cord-024189-t7mbsr25 1059 10 and and CC cord-024189-t7mbsr25 1059 11 follicular follicular JJ cord-024189-t7mbsr25 1059 12 lesions lesion NNS cord-024189-t7mbsr25 1059 13 , , , cord-024189-t7mbsr25 1059 14 but but CC cord-024189-t7mbsr25 1059 15 toxicity toxicity NN cord-024189-t7mbsr25 1059 16 is be VBZ cord-024189-t7mbsr25 1059 17 a a DT cord-024189-t7mbsr25 1059 18 major major JJ cord-024189-t7mbsr25 1059 19 concern concern NN cord-024189-t7mbsr25 1059 20 . . . cord-024189-t7mbsr25 1060 1 Short short JJ cord-024189-t7mbsr25 1060 2 courses course NNS cord-024189-t7mbsr25 1060 3 of of IN cord-024189-t7mbsr25 1060 4 prednisone prednisone NNP cord-024189-t7mbsr25 1060 5 are be VBP cord-024189-t7mbsr25 1060 6 useful useful JJ cord-024189-t7mbsr25 1060 7 in in IN cord-024189-t7mbsr25 1060 8 the the DT cord-024189-t7mbsr25 1060 9 management management NN cord-024189-t7mbsr25 1060 10 of of IN cord-024189-t7mbsr25 1060 11 mucocutaneous mucocutaneous JJ cord-024189-t7mbsr25 1060 12 disease disease NN cord-024189-t7mbsr25 1060 13 in in IN cord-024189-t7mbsr25 1060 14 some some DT cord-024189-t7mbsr25 1060 15 patients patient NNS cord-024189-t7mbsr25 1060 16 . . . cord-024189-t7mbsr25 1061 1 In in IN cord-024189-t7mbsr25 1061 2 others other NNS cord-024189-t7mbsr25 1061 3 , , , cord-024189-t7mbsr25 1061 4 low low JJ cord-024189-t7mbsr25 1061 5 - - HYPH cord-024189-t7mbsr25 1061 6 dose dose NN cord-024189-t7mbsr25 1061 7 prednisone prednisone NN cord-024189-t7mbsr25 1061 8 as as IN cord-024189-t7mbsr25 1061 9 maintenance maintenance NN cord-024189-t7mbsr25 1061 10 therapy therapy NN cord-024189-t7mbsr25 1061 11 is be VBZ cord-024189-t7mbsr25 1061 12 required require VBN cord-024189-t7mbsr25 1061 13 . . . cord-024189-t7mbsr25 1062 1 Cyclosporine cyclosporine NN cord-024189-t7mbsr25 1062 2 can can MD cord-024189-t7mbsr25 1062 3 be be VB cord-024189-t7mbsr25 1062 4 effective effective JJ cord-024189-t7mbsr25 1062 5 for for IN cord-024189-t7mbsr25 1062 6 the the DT cord-024189-t7mbsr25 1062 7 control control NN cord-024189-t7mbsr25 1062 8 of of IN cord-024189-t7mbsr25 1062 9 uveitis uveitis NN cord-024189-t7mbsr25 1062 10 . . . cord-024189-t7mbsr25 1063 1 A a DT cord-024189-t7mbsr25 1063 2 controlled controlled JJ cord-024189-t7mbsr25 1063 3 study study NN cord-024189-t7mbsr25 1063 4 has have VBZ cord-024189-t7mbsr25 1063 5 demonstrated demonstrate VBN cord-024189-t7mbsr25 1063 6 the the DT cord-024189-t7mbsr25 1063 7 value value NN cord-024189-t7mbsr25 1063 8 of of IN cord-024189-t7mbsr25 1063 9 azathioprine azathioprine NN cord-024189-t7mbsr25 1063 10 at at IN cord-024189-t7mbsr25 1063 11 a a DT cord-024189-t7mbsr25 1063 12 dose dose NN cord-024189-t7mbsr25 1063 13 of of IN cord-024189-t7mbsr25 1063 14 2.5 2.5 CD cord-024189-t7mbsr25 1063 15 mg mg NNP cord-024189-t7mbsr25 1063 16 / / SYM cord-024189-t7mbsr25 1063 17 kg kg NN cord-024189-t7mbsr25 1063 18 per per IN cord-024189-t7mbsr25 1063 19 day day NN cord-024189-t7mbsr25 1063 20 in in IN cord-024189-t7mbsr25 1063 21 limiting limit VBG cord-024189-t7mbsr25 1063 22 the the DT cord-024189-t7mbsr25 1063 23 progression progression NN cord-024189-t7mbsr25 1063 24 of of IN cord-024189-t7mbsr25 1063 25 ocular ocular JJ cord-024189-t7mbsr25 1063 26 disease disease NN cord-024189-t7mbsr25 1063 27 and and CC cord-024189-t7mbsr25 1063 28 preventing prevent VBG cord-024189-t7mbsr25 1063 29 new new JJ cord-024189-t7mbsr25 1063 30 eye eye NN cord-024189-t7mbsr25 1063 31 disease disease NN cord-024189-t7mbsr25 1063 32 in in IN cord-024189-t7mbsr25 1063 33 males male NNS cord-024189-t7mbsr25 1063 34 . . . cord-024189-t7mbsr25 1064 1 Combination combination NN cord-024189-t7mbsr25 1064 2 treatment treatment NN cord-024189-t7mbsr25 1064 3 with with IN cord-024189-t7mbsr25 1064 4 cyclosporine cyclosporine NN cord-024189-t7mbsr25 1064 5 and and CC cord-024189-t7mbsr25 1064 6 azathioprine azathioprine NN cord-024189-t7mbsr25 1064 7 can can MD cord-024189-t7mbsr25 1064 8 been be VBN cord-024189-t7mbsr25 1064 9 used use VBN cord-024189-t7mbsr25 1064 10 when when WRB cord-024189-t7mbsr25 1064 11 singleagent singleagent JJ cord-024189-t7mbsr25 1064 12 treatment treatment NN cord-024189-t7mbsr25 1064 13 has have VBZ cord-024189-t7mbsr25 1064 14 failed fail VBN cord-024189-t7mbsr25 1064 15 . . . cord-024189-t7mbsr25 1065 1 Azathioprine Azathioprine NNP cord-024189-t7mbsr25 1065 2 can can MD cord-024189-t7mbsr25 1065 3 have have VB cord-024189-t7mbsr25 1065 4 a a DT cord-024189-t7mbsr25 1065 5 benefi benefi JJ cord-024189-t7mbsr25 1065 6 cial cial JJ cord-024189-t7mbsr25 1065 7 effect effect NN cord-024189-t7mbsr25 1065 8 on on IN cord-024189-t7mbsr25 1065 9 mucosal mucosal JJ cord-024189-t7mbsr25 1065 10 ulcers ulcer NNS cord-024189-t7mbsr25 1065 11 , , , cord-024189-t7mbsr25 1065 12 arthritis arthritis NN cord-024189-t7mbsr25 1065 13 , , , cord-024189-t7mbsr25 1065 14 deep deep JJ cord-024189-t7mbsr25 1065 15 venous venous JJ cord-024189-t7mbsr25 1065 16 thrombosis thrombosis NN cord-024189-t7mbsr25 1065 17 , , , cord-024189-t7mbsr25 1065 18 and and CC cord-024189-t7mbsr25 1065 19 long long JJ cord-024189-t7mbsr25 1065 20 - - HYPH cord-024189-t7mbsr25 1065 21 term term NN cord-024189-t7mbsr25 1065 22 prognosis prognosis NN cord-024189-t7mbsr25 1065 23 ( ( -LRB- cord-024189-t7mbsr25 1065 24 10 10 CD cord-024189-t7mbsr25 1065 25 ) ) -RRB- cord-024189-t7mbsr25 1065 26 . . . cord-024189-t7mbsr25 1066 1 Because because IN cord-024189-t7mbsr25 1066 2 young young JJ cord-024189-t7mbsr25 1066 3 males male NNS cord-024189-t7mbsr25 1066 4 are be VBP cord-024189-t7mbsr25 1066 5 at at IN cord-024189-t7mbsr25 1066 6 the the DT cord-024189-t7mbsr25 1066 7 greatest great JJS cord-024189-t7mbsr25 1066 8 risk risk NN cord-024189-t7mbsr25 1066 9 for for IN cord-024189-t7mbsr25 1066 10 severe severe JJ cord-024189-t7mbsr25 1066 11 disease disease NN cord-024189-t7mbsr25 1066 12 , , , cord-024189-t7mbsr25 1066 13 especially especially RB cord-024189-t7mbsr25 1066 14 uveitis uveitis NN cord-024189-t7mbsr25 1066 15 , , , cord-024189-t7mbsr25 1066 16 aggressive aggressive JJ cord-024189-t7mbsr25 1066 17 treatment treatment NN cord-024189-t7mbsr25 1066 18 is be VBZ cord-024189-t7mbsr25 1066 19 warranted warrant VBN cord-024189-t7mbsr25 1066 20 in in IN cord-024189-t7mbsr25 1066 21 this this DT cord-024189-t7mbsr25 1066 22 disease disease NN cord-024189-t7mbsr25 1066 23 subset subset VBN cord-024189-t7mbsr25 1066 24 . . . cord-024189-t7mbsr25 1067 1 In in IN cord-024189-t7mbsr25 1067 2 open open JJ cord-024189-t7mbsr25 1067 3 trials trial NNS cord-024189-t7mbsr25 1067 4 , , , cord-024189-t7mbsr25 1067 5 interferon interferon NN cord-024189-t7mbsr25 1067 6 - - HYPH cord-024189-t7mbsr25 1067 7 alpha alpha NN cord-024189-t7mbsr25 1067 8 has have VBZ cord-024189-t7mbsr25 1067 9 been be VBN cord-024189-t7mbsr25 1067 10 found find VBN cord-024189-t7mbsr25 1067 11 useful useful JJ cord-024189-t7mbsr25 1067 12 for for IN cord-024189-t7mbsr25 1067 13 treating treat VBG cord-024189-t7mbsr25 1067 14 mucocutaneous mucocutaneous JJ cord-024189-t7mbsr25 1067 15 lesions lesion NNS cord-024189-t7mbsr25 1067 16 and and CC cord-024189-t7mbsr25 1067 17 arthritis arthritis NN cord-024189-t7mbsr25 1067 18 and and CC cord-024189-t7mbsr25 1067 19 is be VBZ cord-024189-t7mbsr25 1067 20 emerging emerge VBG cord-024189-t7mbsr25 1067 21 as as IN cord-024189-t7mbsr25 1067 22 an an DT cord-024189-t7mbsr25 1067 23 effective effective JJ cord-024189-t7mbsr25 1067 24 treatment treatment NN cord-024189-t7mbsr25 1067 25 for for IN cord-024189-t7mbsr25 1067 26 ocular ocular JJ cord-024189-t7mbsr25 1067 27 disease disease NN cord-024189-t7mbsr25 1067 28 ( ( -LRB- cord-024189-t7mbsr25 1067 29 11 11 CD cord-024189-t7mbsr25 1067 30 ) ) -RRB- cord-024189-t7mbsr25 1067 31 . . . cord-024189-t7mbsr25 1068 1 Etanercept Etanercept NNP cord-024189-t7mbsr25 1068 2 , , , cord-024189-t7mbsr25 1068 3 a a DT cord-024189-t7mbsr25 1068 4 tumor tumor NN cord-024189-t7mbsr25 1068 5 necrosis necrosis NN cord-024189-t7mbsr25 1068 6 factor factor NN cord-024189-t7mbsr25 1068 7 inhibitor inhibitor NN cord-024189-t7mbsr25 1068 8 , , , cord-024189-t7mbsr25 1068 9 was be VBD cord-024189-t7mbsr25 1068 10 shown show VBN cord-024189-t7mbsr25 1068 11 to to TO cord-024189-t7mbsr25 1068 12 be be VB cord-024189-t7mbsr25 1068 13 benefi benefi NNP cord-024189-t7mbsr25 1068 14 cial cial NNP cord-024189-t7mbsr25 1068 15 for for IN cord-024189-t7mbsr25 1068 16 mucocutaneous mucocutaneous JJ cord-024189-t7mbsr25 1068 17 manifestations manifestation NNS cord-024189-t7mbsr25 1068 18 in in IN cord-024189-t7mbsr25 1068 19 a a DT cord-024189-t7mbsr25 1068 20 controlled control VBN cord-024189-t7mbsr25 1068 21 study study NN cord-024189-t7mbsr25 1068 22 ( ( -LRB- cord-024189-t7mbsr25 1068 23 12 12 CD cord-024189-t7mbsr25 1068 24 ) ) -RRB- cord-024189-t7mbsr25 1068 25 . . . cord-024189-t7mbsr25 1069 1 Reports report NNS cord-024189-t7mbsr25 1069 2 of of IN cord-024189-t7mbsr25 1069 3 uncontrolled uncontrolled JJ cord-024189-t7mbsr25 1069 4 experience experience NN cord-024189-t7mbsr25 1069 5 with with IN cord-024189-t7mbsr25 1069 6 infl infl NNP cord-024189-t7mbsr25 1069 7 iximab iximab NNS cord-024189-t7mbsr25 1069 8 for for IN cord-024189-t7mbsr25 1069 9 eye eye NN cord-024189-t7mbsr25 1069 10 infl infl NN cord-024189-t7mbsr25 1069 11 ammation ammation NNP cord-024189-t7mbsr25 1069 12 have have VBP cord-024189-t7mbsr25 1069 13 been be VBN cord-024189-t7mbsr25 1069 14 positive positive JJ cord-024189-t7mbsr25 1069 15 , , , cord-024189-t7mbsr25 1069 16 but but CC cord-024189-t7mbsr25 1069 17 controlled control VBN cord-024189-t7mbsr25 1069 18 data datum NNS cord-024189-t7mbsr25 1069 19 are be VBP cord-024189-t7mbsr25 1069 20 lacking lack VBG cord-024189-t7mbsr25 1069 21 . . . cord-024189-t7mbsr25 1070 1 Immunosuppression Immunosuppression NNP cord-024189-t7mbsr25 1070 2 with with IN cord-024189-t7mbsr25 1070 3 chlorambucil chlorambucil NN cord-024189-t7mbsr25 1070 4 or or CC cord-024189-t7mbsr25 1070 5 cyclophosphamide cyclophosphamide RB cord-024189-t7mbsr25 1070 6 is be VBZ cord-024189-t7mbsr25 1070 7 used use VBN cord-024189-t7mbsr25 1070 8 for for IN cord-024189-t7mbsr25 1070 9 uncontrolled uncontrolled JJ cord-024189-t7mbsr25 1070 10 ocular ocular JJ cord-024189-t7mbsr25 1070 11 disease disease NN cord-024189-t7mbsr25 1070 12 , , , cord-024189-t7mbsr25 1070 13 central central JJ cord-024189-t7mbsr25 1070 14 nervous nervous JJ cord-024189-t7mbsr25 1070 15 system system NN cord-024189-t7mbsr25 1070 16 disease disease NN cord-024189-t7mbsr25 1070 17 , , , cord-024189-t7mbsr25 1070 18 and and CC cord-024189-t7mbsr25 1070 19 large large JJ cord-024189-t7mbsr25 1070 20 vessel vessel NN cord-024189-t7mbsr25 1070 21 vasculitis vasculitis NN cord-024189-t7mbsr25 1070 22 , , , cord-024189-t7mbsr25 1070 23 including include VBG cord-024189-t7mbsr25 1070 24 recurrent recurrent JJ cord-024189-t7mbsr25 1070 25 deep deep JJ cord-024189-t7mbsr25 1070 26 venous venous JJ cord-024189-t7mbsr25 1070 27 thrombosis thrombosis NN cord-024189-t7mbsr25 1070 28 . . . cord-024189-t7mbsr25 1071 1 Glucocorticoids glucocorticoid NNS cord-024189-t7mbsr25 1071 2 are be VBP cord-024189-t7mbsr25 1071 3 useful useful JJ cord-024189-t7mbsr25 1071 4 in in IN cord-024189-t7mbsr25 1071 5 suppression suppression NN cord-024189-t7mbsr25 1071 6 of of IN cord-024189-t7mbsr25 1071 7 infl infl NNP cord-024189-t7mbsr25 1071 8 ammation ammation NNP cord-024189-t7mbsr25 1071 9 in in IN cord-024189-t7mbsr25 1071 10 acute acute JJ cord-024189-t7mbsr25 1071 11 phases phase NNS cord-024189-t7mbsr25 1071 12 of of IN cord-024189-t7mbsr25 1071 13 the the DT cord-024189-t7mbsr25 1071 14 disease disease NN cord-024189-t7mbsr25 1071 15 , , , cord-024189-t7mbsr25 1071 16 but but CC cord-024189-t7mbsr25 1071 17 these these DT cord-024189-t7mbsr25 1071 18 agents agent NNS cord-024189-t7mbsr25 1071 19 are be VBP cord-024189-t7mbsr25 1071 20 insuffi insuffi NNP cord-024189-t7mbsr25 1071 21 cient cient NN cord-024189-t7mbsr25 1071 22 by by IN cord-024189-t7mbsr25 1071 23 themselves -PRON- PRP cord-024189-t7mbsr25 1071 24 to to TO cord-024189-t7mbsr25 1071 25 treat treat VB cord-024189-t7mbsr25 1071 26 such such JJ cord-024189-t7mbsr25 1071 27 severe severe JJ cord-024189-t7mbsr25 1071 28 disease disease NN cord-024189-t7mbsr25 1071 29 manifestations manifestation NNS cord-024189-t7mbsr25 1071 30 as as IN cord-024189-t7mbsr25 1071 31 posterior posterior JJ cord-024189-t7mbsr25 1071 32 uveitis uveitis NN cord-024189-t7mbsr25 1071 33 or or CC cord-024189-t7mbsr25 1071 34 parenchymal parenchymal NN cord-024189-t7mbsr25 1071 35 brain brain NN cord-024189-t7mbsr25 1071 36 disease disease NN cord-024189-t7mbsr25 1071 37 . . . cord-024189-t7mbsr25 1072 1 Because because IN cord-024189-t7mbsr25 1072 2 of of IN cord-024189-t7mbsr25 1072 3 the the DT cord-024189-t7mbsr25 1072 4 high high JJ cord-024189-t7mbsr25 1072 5 risk risk NN cord-024189-t7mbsr25 1072 6 of of IN cord-024189-t7mbsr25 1072 7 rupture rupture NN cord-024189-t7mbsr25 1072 8 , , , cord-024189-t7mbsr25 1072 9 surgical surgical JJ cord-024189-t7mbsr25 1072 10 treatment treatment NN cord-024189-t7mbsr25 1072 11 is be VBZ cord-024189-t7mbsr25 1072 12 indicated indicate VBN cord-024189-t7mbsr25 1072 13 for for IN cord-024189-t7mbsr25 1072 14 systemic systemic JJ cord-024189-t7mbsr25 1072 15 arterial arterial JJ cord-024189-t7mbsr25 1072 16 aneurysms aneurysm NNS cord-024189-t7mbsr25 1072 17 . . . cord-024189-t7mbsr25 1073 1 Glucocorticoids Glucocorticoids NNP cord-024189-t7mbsr25 1073 2 and and CC cord-024189-t7mbsr25 1073 3 alkylating alkylating JJ cord-024189-t7mbsr25 1073 4 agents agent NNS cord-024189-t7mbsr25 1073 5 should should MD cord-024189-t7mbsr25 1073 6 also also RB cord-024189-t7mbsr25 1073 7 be be VB cord-024189-t7mbsr25 1073 8 used use VBN cord-024189-t7mbsr25 1073 9 to to TO cord-024189-t7mbsr25 1073 10 minimize minimize VB cord-024189-t7mbsr25 1073 11 the the DT cord-024189-t7mbsr25 1073 12 high high JJ cord-024189-t7mbsr25 1073 13 risk risk NN cord-024189-t7mbsr25 1073 14 of of IN cord-024189-t7mbsr25 1073 15 anastomotic anastomotic JJ cord-024189-t7mbsr25 1073 16 recurrences recurrence NNS cord-024189-t7mbsr25 1073 17 or or CC cord-024189-t7mbsr25 1073 18 continued continue VBN cord-024189-t7mbsr25 1073 19 disease disease NN cord-024189-t7mbsr25 1073 20 . . . cord-024189-t7mbsr25 1074 1 Pulmonary pulmonary JJ cord-024189-t7mbsr25 1074 2 arterial arterial JJ cord-024189-t7mbsr25 1074 3 aneurysms aneurysm NNS cord-024189-t7mbsr25 1074 4 may may MD cord-024189-t7mbsr25 1074 5 respond respond VB cord-024189-t7mbsr25 1074 6 to to IN cord-024189-t7mbsr25 1074 7 these these DT cord-024189-t7mbsr25 1074 8 same same JJ cord-024189-t7mbsr25 1074 9 medications medication NNS cord-024189-t7mbsr25 1074 10 , , , cord-024189-t7mbsr25 1074 11 but but CC cord-024189-t7mbsr25 1074 12 uncontrolled uncontrolled JJ cord-024189-t7mbsr25 1074 13 bleeding bleeding NN cord-024189-t7mbsr25 1074 14 requires require VBZ cord-024189-t7mbsr25 1074 15 percutaneous percutaneous JJ cord-024189-t7mbsr25 1074 16 embolization embolization NN cord-024189-t7mbsr25 1074 17 or or CC cord-024189-t7mbsr25 1074 18 surgical surgical JJ cord-024189-t7mbsr25 1074 19 treatment treatment NN cord-024189-t7mbsr25 1074 20 . . . cord-024189-t7mbsr25 1075 1 Cerebral cerebral JJ cord-024189-t7mbsr25 1075 2 venous venous JJ cord-024189-t7mbsr25 1075 3 thrombosis thrombosis NN cord-024189-t7mbsr25 1075 4 is be VBZ cord-024189-t7mbsr25 1075 5 treated treat VBN cord-024189-t7mbsr25 1075 6 with with IN cord-024189-t7mbsr25 1075 7 anticoagulation anticoagulation NN cord-024189-t7mbsr25 1075 8 and and CC cord-024189-t7mbsr25 1075 9 corticosteroids corticosteroid NNS cord-024189-t7mbsr25 1075 10 . . . cord-024189-t7mbsr25 1076 1 The the DT cord-024189-t7mbsr25 1076 2 treatment treatment NN cord-024189-t7mbsr25 1076 3 of of IN cord-024189-t7mbsr25 1076 4 Budd Budd NNP cord-024189-t7mbsr25 1076 5 - - HYPH cord-024189-t7mbsr25 1076 6 Chiari Chiari NNP cord-024189-t7mbsr25 1076 7 syndrome syndrome NN cord-024189-t7mbsr25 1076 8 has have VBZ cord-024189-t7mbsr25 1076 9 included include VBN cord-024189-t7mbsr25 1076 10 anticoagulants anticoagulant NNS cord-024189-t7mbsr25 1076 11 or or CC cord-024189-t7mbsr25 1076 12 antiaggregants antiaggregant NNS cord-024189-t7mbsr25 1076 13 , , , cord-024189-t7mbsr25 1076 14 colchicine colchicine NN cord-024189-t7mbsr25 1076 15 , , , cord-024189-t7mbsr25 1076 16 and and CC cord-024189-t7mbsr25 1076 17 glucocorticoids glucocorticoid NNS cord-024189-t7mbsr25 1076 18 . . . cord-024189-t7mbsr25 1077 1 Portocaval portocaval JJ cord-024189-t7mbsr25 1077 2 shunting shunting NN cord-024189-t7mbsr25 1077 3 should should MD cord-024189-t7mbsr25 1077 4 be be VB cord-024189-t7mbsr25 1077 5 considered consider VBN cord-024189-t7mbsr25 1077 6 if if IN cord-024189-t7mbsr25 1077 7 the the DT cord-024189-t7mbsr25 1077 8 inferior inferior JJ cord-024189-t7mbsr25 1077 9 vena vena FW cord-024189-t7mbsr25 1077 10 cava cava NN cord-024189-t7mbsr25 1077 11 is be VBZ cord-024189-t7mbsr25 1077 12 patent patent NN cord-024189-t7mbsr25 1077 13 . . . cord-024189-t7mbsr25 1078 1 In in IN cord-024189-t7mbsr25 1078 2 many many JJ cord-024189-t7mbsr25 1078 3 geographic geographic JJ cord-024189-t7mbsr25 1078 4 areas area NNS cord-024189-t7mbsr25 1078 5 , , , cord-024189-t7mbsr25 1078 6 genetic genetic JJ cord-024189-t7mbsr25 1078 7 studies study NNS cord-024189-t7mbsr25 1078 8 have have VBP cord-024189-t7mbsr25 1078 9 shown show VBN cord-024189-t7mbsr25 1078 10 a a DT cord-024189-t7mbsr25 1078 11 strong strong JJ cord-024189-t7mbsr25 1078 12 association association NN cord-024189-t7mbsr25 1078 13 with with IN cord-024189-t7mbsr25 1078 14 HLA HLA NNP cord-024189-t7mbsr25 1078 15 - - HYPH cord-024189-t7mbsr25 1078 16 B51 B51 NNP cord-024189-t7mbsr25 1078 17 , , , cord-024189-t7mbsr25 1078 18 but but CC cord-024189-t7mbsr25 1078 19 the the DT cord-024189-t7mbsr25 1078 20 exact exact JJ cord-024189-t7mbsr25 1078 21 role role NN cord-024189-t7mbsr25 1078 22 of of IN cord-024189-t7mbsr25 1078 23 this this DT cord-024189-t7mbsr25 1078 24 gene gene NN cord-024189-t7mbsr25 1078 25 in in IN cord-024189-t7mbsr25 1078 26 the the DT cord-024189-t7mbsr25 1078 27 development development NN cord-024189-t7mbsr25 1078 28 of of IN cord-024189-t7mbsr25 1078 29 BD BD NNP cord-024189-t7mbsr25 1078 30 is be VBZ cord-024189-t7mbsr25 1078 31 uncertain uncertain JJ cord-024189-t7mbsr25 1078 32 . . . cord-024189-t7mbsr25 1079 1 Neutrophilic Neutrophilic NNP cord-024189-t7mbsr25 1079 2 hyperfunction hyperfunction NN cord-024189-t7mbsr25 1079 3 is be VBZ cord-024189-t7mbsr25 1079 4 recognized recognize VBN cord-024189-t7mbsr25 1079 5 in in IN cord-024189-t7mbsr25 1079 6 BD BD NNP cord-024189-t7mbsr25 1079 7 , , , cord-024189-t7mbsr25 1079 8 in in IN cord-024189-t7mbsr25 1079 9 normal normal JJ cord-024189-t7mbsr25 1079 10 subjects subject NNS cord-024189-t7mbsr25 1079 11 with with IN cord-024189-t7mbsr25 1079 12 HLA HLA NNP cord-024189-t7mbsr25 1079 13 - - HYPH cord-024189-t7mbsr25 1079 14 B51 B51 NNP cord-024189-t7mbsr25 1079 15 , , , cord-024189-t7mbsr25 1079 16 and and CC cord-024189-t7mbsr25 1079 17 in in IN cord-024189-t7mbsr25 1079 18 HLA HLA NNP cord-024189-t7mbsr25 1079 19 - - HYPH cord-024189-t7mbsr25 1079 20 B51 B51 NNP cord-024189-t7mbsr25 1079 21 transgenic transgenic JJ cord-024189-t7mbsr25 1079 22 mice mouse NNS cord-024189-t7mbsr25 1079 23 ( ( -LRB- cord-024189-t7mbsr25 1079 24 13 13 CD cord-024189-t7mbsr25 1079 25 ) ) -RRB- cord-024189-t7mbsr25 1079 26 . . . cord-024189-t7mbsr25 1080 1 Evidence evidence NN cord-024189-t7mbsr25 1080 2 also also RB cord-024189-t7mbsr25 1080 3 exists exist VBZ cord-024189-t7mbsr25 1080 4 for for IN cord-024189-t7mbsr25 1080 5 antigen antigen NN cord-024189-t7mbsr25 1080 6 - - HYPH cord-024189-t7mbsr25 1080 7 driven drive VBN cord-024189-t7mbsr25 1080 8 immune immune JJ cord-024189-t7mbsr25 1080 9 mechanisms mechanism NNS cord-024189-t7mbsr25 1080 10 in in IN cord-024189-t7mbsr25 1080 11 the the DT cord-024189-t7mbsr25 1080 12 pathogenesis pathogenesis NN cord-024189-t7mbsr25 1080 13 of of IN cord-024189-t7mbsr25 1080 14 BD BD NNP cord-024189-t7mbsr25 1080 15 . . . cord-024189-t7mbsr25 1081 1 Cytokine cytokine NN cord-024189-t7mbsr25 1081 2 analysis analysis NN cord-024189-t7mbsr25 1081 3 and and CC cord-024189-t7mbsr25 1081 4 cellular cellular JJ cord-024189-t7mbsr25 1081 5 characterization characterization NN cord-024189-t7mbsr25 1081 6 suggest suggest VBP cord-024189-t7mbsr25 1081 7 a a DT cord-024189-t7mbsr25 1081 8 Thelper Thelper NNP cord-024189-t7mbsr25 1081 9 cell cell NN cord-024189-t7mbsr25 1081 10 ( ( -LRB- cord-024189-t7mbsr25 1081 11 Th1 th1 CD cord-024189-t7mbsr25 1081 12 ) ) -RRB- cord-024189-t7mbsr25 1081 13 response response NN cord-024189-t7mbsr25 1081 14 by by IN cord-024189-t7mbsr25 1081 15 lymphocytes lymphocyte NNS cord-024189-t7mbsr25 1081 16 in in IN cord-024189-t7mbsr25 1081 17 BD BD NNP cord-024189-t7mbsr25 1081 18 . . . cord-024189-t7mbsr25 1082 1 Molecular molecular JJ cord-024189-t7mbsr25 1082 2 techniques technique NNS cord-024189-t7mbsr25 1082 3 have have VBP cord-024189-t7mbsr25 1082 4 identifi identifi VBN cord-024189-t7mbsr25 1082 5 ed ed NNP cord-024189-t7mbsr25 1082 6 herpes herpes NNP cord-024189-t7mbsr25 1082 7 simplex simplex NNP cord-024189-t7mbsr25 1082 8 viral viral JJ cord-024189-t7mbsr25 1082 9 RNA RNA NNP cord-024189-t7mbsr25 1082 10 and and CC cord-024189-t7mbsr25 1082 11 DNA DNA NNP cord-024189-t7mbsr25 1082 12 in in IN cord-024189-t7mbsr25 1082 13 cells cell NNS cord-024189-t7mbsr25 1082 14 from from IN cord-024189-t7mbsr25 1082 15 patients patient NNS cord-024189-t7mbsr25 1082 16 with with IN cord-024189-t7mbsr25 1082 17 BD BD NNP cord-024189-t7mbsr25 1082 18 , , , cord-024189-t7mbsr25 1082 19 and and CC cord-024189-t7mbsr25 1082 20 streptococcal streptococcal JJ cord-024189-t7mbsr25 1082 21 antigens antigen NNS cord-024189-t7mbsr25 1082 22 have have VBP cord-024189-t7mbsr25 1082 23 been be VBN cord-024189-t7mbsr25 1082 24 proposed propose VBN cord-024189-t7mbsr25 1082 25 as as IN cord-024189-t7mbsr25 1082 26 triggers trigger NNS cord-024189-t7mbsr25 1082 27 of of IN cord-024189-t7mbsr25 1082 28 active active JJ cord-024189-t7mbsr25 1082 29 disease disease NN cord-024189-t7mbsr25 1082 30 . . . cord-024189-t7mbsr25 1083 1 Activated activate VBN cord-024189-t7mbsr25 1083 2 gamma gamma NN cord-024189-t7mbsr25 1083 3 - - HYPH cord-024189-t7mbsr25 1083 4 delta delta NN cord-024189-t7mbsr25 1083 5 T t NN cord-024189-t7mbsr25 1083 6 cells cell NNS cord-024189-t7mbsr25 1083 7 are be VBP cord-024189-t7mbsr25 1083 8 increased increase VBN cord-024189-t7mbsr25 1083 9 in in IN cord-024189-t7mbsr25 1083 10 the the DT cord-024189-t7mbsr25 1083 11 circulation circulation NN cord-024189-t7mbsr25 1083 12 and and CC cord-024189-t7mbsr25 1083 13 in in IN cord-024189-t7mbsr25 1083 14 mucosal mucosal JJ cord-024189-t7mbsr25 1083 15 lesions lesion NNS cord-024189-t7mbsr25 1083 16 , , , cord-024189-t7mbsr25 1083 17 but but CC cord-024189-t7mbsr25 1083 18 the the DT cord-024189-t7mbsr25 1083 19 precise precise JJ cord-024189-t7mbsr25 1083 20 role role NN cord-024189-t7mbsr25 1083 21 of of IN cord-024189-t7mbsr25 1083 22 these these DT cord-024189-t7mbsr25 1083 23 cells cell NNS cord-024189-t7mbsr25 1083 24 in in IN cord-024189-t7mbsr25 1083 25 the the DT cord-024189-t7mbsr25 1083 26 pathogenesis pathogenesis NN cord-024189-t7mbsr25 1083 27 of of IN cord-024189-t7mbsr25 1083 28 BD BD NNP cord-024189-t7mbsr25 1083 29 is be VBZ cord-024189-t7mbsr25 1083 30 uncertain uncertain JJ cord-024189-t7mbsr25 1083 31 . . . cord-024189-t7mbsr25 1084 1 Peptides peptide NNS cord-024189-t7mbsr25 1084 2 from from IN cord-024189-t7mbsr25 1084 3 mycobacterial mycobacterial NNP cord-024189-t7mbsr25 1084 4 heat heat NN cord-024189-t7mbsr25 1084 5 shock shock NN cord-024189-t7mbsr25 1084 6 protein protein NN cord-024189-t7mbsr25 1084 7 ( ( -LRB- cord-024189-t7mbsr25 1084 8 HSP HSP NNP cord-024189-t7mbsr25 1084 9 ) ) -RRB- cord-024189-t7mbsr25 1084 10 and and CC cord-024189-t7mbsr25 1084 11 homologous homologous JJ cord-024189-t7mbsr25 1084 12 human human JJ cord-024189-t7mbsr25 1084 13 peptides peptide NNS cord-024189-t7mbsr25 1084 14 have have VBP cord-024189-t7mbsr25 1084 15 been be VBN cord-024189-t7mbsr25 1084 16 found find VBN cord-024189-t7mbsr25 1084 17 to to TO cord-024189-t7mbsr25 1084 18 stimulate stimulate VB cord-024189-t7mbsr25 1084 19 gd+ gd+ NNP cord-024189-t7mbsr25 1084 20 T t NN cord-024189-t7mbsr25 1084 21 cells cell NNS cord-024189-t7mbsr25 1084 22 from from IN cord-024189-t7mbsr25 1084 23 patients patient NNS cord-024189-t7mbsr25 1084 24 with with IN cord-024189-t7mbsr25 1084 25 BD BD NNP cord-024189-t7mbsr25 1084 26 in in IN cord-024189-t7mbsr25 1084 27 a a DT cord-024189-t7mbsr25 1084 28 specifi specifi NN cord-024189-t7mbsr25 1084 29 c c NN cord-024189-t7mbsr25 1084 30 fashion fashion NN cord-024189-t7mbsr25 1084 31 ( ( -LRB- cord-024189-t7mbsr25 1084 32 14 14 CD cord-024189-t7mbsr25 1084 33 ) ) -RRB- cord-024189-t7mbsr25 1084 34 . . . cord-024189-t7mbsr25 1085 1 Cross cross NN cord-024189-t7mbsr25 1085 2 - - NN cord-024189-t7mbsr25 1085 3 reactivity reactivity NN cord-024189-t7mbsr25 1085 4 and and CC cord-024189-t7mbsr25 1085 5 molecular molecular JJ cord-024189-t7mbsr25 1085 6 mimicry mimicry NN cord-024189-t7mbsr25 1085 7 between between IN cord-024189-t7mbsr25 1085 8 peptides peptide NNS cord-024189-t7mbsr25 1085 9 from from IN cord-024189-t7mbsr25 1085 10 streptococcal streptococcal JJ cord-024189-t7mbsr25 1085 11 or or CC cord-024189-t7mbsr25 1085 12 viral viral JJ cord-024189-t7mbsr25 1085 13 HSP HSP NNP cord-024189-t7mbsr25 1085 14 , , , cord-024189-t7mbsr25 1085 15 homologous homologous JJ cord-024189-t7mbsr25 1085 16 human human JJ cord-024189-t7mbsr25 1085 17 HSP HSP NNP cord-024189-t7mbsr25 1085 18 , , , cord-024189-t7mbsr25 1085 19 and and CC cord-024189-t7mbsr25 1085 20 mucosal mucosal JJ cord-024189-t7mbsr25 1085 21 antigens antigen NNS cord-024189-t7mbsr25 1085 22 may may MD cord-024189-t7mbsr25 1085 23 result result VB cord-024189-t7mbsr25 1085 24 in in IN cord-024189-t7mbsr25 1085 25 selection selection NN cord-024189-t7mbsr25 1085 26 of of IN cord-024189-t7mbsr25 1085 27 autoreactive autoreactive JJ cord-024189-t7mbsr25 1085 28 T t NN cord-024189-t7mbsr25 1085 29 cells cell NNS cord-024189-t7mbsr25 1085 30 ( ( -LRB- cord-024189-t7mbsr25 1085 31 15 15 CD cord-024189-t7mbsr25 1085 32 ) ) -RRB- cord-024189-t7mbsr25 1085 33 . . . cord-024189-t7mbsr25 1086 1 More more RBR cord-024189-t7mbsr25 1086 2 recently recently RB cord-024189-t7mbsr25 1086 3 , , , cord-024189-t7mbsr25 1086 4 similarities similarity NNS cord-024189-t7mbsr25 1086 5 between between IN cord-024189-t7mbsr25 1086 6 BD BD NNP cord-024189-t7mbsr25 1086 7 and and CC cord-024189-t7mbsr25 1086 8 infl infl NNP cord-024189-t7mbsr25 1086 9 ammatory ammatory NNP cord-024189-t7mbsr25 1086 10 disorders disorder NNS cord-024189-t7mbsr25 1086 11 associated associate VBN cord-024189-t7mbsr25 1086 12 with with IN cord-024189-t7mbsr25 1086 13 autoimmunity autoimmunity NN cord-024189-t7mbsr25 1086 14 have have VBP cord-024189-t7mbsr25 1086 15 been be VBN cord-024189-t7mbsr25 1086 16 recognized recognize VBN cord-024189-t7mbsr25 1086 17 ( ( -LRB- cord-024189-t7mbsr25 1086 18 16 16 CD cord-024189-t7mbsr25 1086 19 ) ) -RRB- cord-024189-t7mbsr25 1086 20 . . . cord-024189-t7mbsr25 1087 1 Primary primary JJ cord-024189-t7mbsr25 1087 2 angiitis angiitis RB cord-024189-t7mbsr25 1087 3 of of IN cord-024189-t7mbsr25 1087 4 the the DT cord-024189-t7mbsr25 1087 5 central central JJ cord-024189-t7mbsr25 1087 6 nervous nervous JJ cord-024189-t7mbsr25 1087 7 system system NN cord-024189-t7mbsr25 1087 8 ( ( -LRB- cord-024189-t7mbsr25 1087 9 PACNS PACNS NNP cord-024189-t7mbsr25 1087 10 ) ) -RRB- cord-024189-t7mbsr25 1087 11 is be VBZ cord-024189-t7mbsr25 1087 12 a a DT cord-024189-t7mbsr25 1087 13 rare rare JJ cord-024189-t7mbsr25 1087 14 form form NN cord-024189-t7mbsr25 1087 15 of of IN cord-024189-t7mbsr25 1087 16 vasculitis vasculitis NN cord-024189-t7mbsr25 1087 17 limited limit VBN cord-024189-t7mbsr25 1087 18 to to IN cord-024189-t7mbsr25 1087 19 the the DT cord-024189-t7mbsr25 1087 20 brain brain NN cord-024189-t7mbsr25 1087 21 and and CC cord-024189-t7mbsr25 1087 22 spinal spinal JJ cord-024189-t7mbsr25 1087 23 cord cord NN cord-024189-t7mbsr25 1087 24 . . . cord-024189-t7mbsr25 1088 1 The the DT cord-024189-t7mbsr25 1088 2 term term NN cord-024189-t7mbsr25 1088 3 granulomatosis granulomatosis NN cord-024189-t7mbsr25 1088 4 angiitis angiitis RB cord-024189-t7mbsr25 1088 5 of of IN cord-024189-t7mbsr25 1088 6 the the DT cord-024189-t7mbsr25 1088 7 central central JJ cord-024189-t7mbsr25 1088 8 nervous nervous JJ cord-024189-t7mbsr25 1088 9 system system NN cord-024189-t7mbsr25 1088 10 was be VBD cord-024189-t7mbsr25 1088 11 previously previously RB cord-024189-t7mbsr25 1088 12 applied apply VBN cord-024189-t7mbsr25 1088 13 because because IN cord-024189-t7mbsr25 1088 14 of of IN cord-024189-t7mbsr25 1088 15 the the DT cord-024189-t7mbsr25 1088 16 histopathologic histopathologic NNP cord-024189-t7mbsr25 1088 17 fi fi NNP cord-024189-t7mbsr25 1088 18 ndings nding NNS cord-024189-t7mbsr25 1088 19 observed observe VBN cord-024189-t7mbsr25 1088 20 in in IN cord-024189-t7mbsr25 1088 21 arteries artery NNS cord-024189-t7mbsr25 1088 22 from from IN cord-024189-t7mbsr25 1088 23 early early JJ cord-024189-t7mbsr25 1088 24 reported report VBN cord-024189-t7mbsr25 1088 25 cases case NNS cord-024189-t7mbsr25 1088 26 . . . cord-024189-t7mbsr25 1089 1 However however RB cord-024189-t7mbsr25 1089 2 , , , cord-024189-t7mbsr25 1089 3 an an DT cord-024189-t7mbsr25 1089 4 analysis analysis NN cord-024189-t7mbsr25 1089 5 of of IN cord-024189-t7mbsr25 1089 6 a a DT cord-024189-t7mbsr25 1089 7 larger large JJR cord-024189-t7mbsr25 1089 8 number number NN cord-024189-t7mbsr25 1089 9 of of IN cord-024189-t7mbsr25 1089 10 cases case NNS cord-024189-t7mbsr25 1089 11 supports support VBZ cord-024189-t7mbsr25 1089 12 varied varied JJ cord-024189-t7mbsr25 1089 13 mononuclear mononuclear JJ cord-024189-t7mbsr25 1089 14 cell cell NN cord-024189-t7mbsr25 1089 15 infi infi NNP cord-024189-t7mbsr25 1089 16 ltrates ltrates NNP cord-024189-t7mbsr25 1089 17 , , , cord-024189-t7mbsr25 1089 18 with with IN cord-024189-t7mbsr25 1089 19 fewer few JJR cord-024189-t7mbsr25 1089 20 than than IN cord-024189-t7mbsr25 1089 21 50 50 CD cord-024189-t7mbsr25 1089 22 % % NN cord-024189-t7mbsr25 1089 23 of of IN cord-024189-t7mbsr25 1089 24 cases case NNS cord-024189-t7mbsr25 1089 25 showing show VBG cord-024189-t7mbsr25 1089 26 granulomatous granulomatous JJ cord-024189-t7mbsr25 1089 27 infl infl NN cord-024189-t7mbsr25 1089 28 ammation ammation NNP cord-024189-t7mbsr25 1089 29 ( ( -LRB- cord-024189-t7mbsr25 1089 30 17 17 CD cord-024189-t7mbsr25 1089 31 ) ) -RRB- cord-024189-t7mbsr25 1089 32 . . . cord-024189-t7mbsr25 1090 1 Anatomically anatomically RB cord-024189-t7mbsr25 1090 2 , , , cord-024189-t7mbsr25 1090 3 the the DT cord-024189-t7mbsr25 1090 4 angiitis angiitis NN cord-024189-t7mbsr25 1090 5 is be VBZ cord-024189-t7mbsr25 1090 6 multifocal multifocal JJ cord-024189-t7mbsr25 1090 7 and and CC cord-024189-t7mbsr25 1090 8 segmental segmental JJ cord-024189-t7mbsr25 1090 9 in in IN cord-024189-t7mbsr25 1090 10 distribution distribution NN cord-024189-t7mbsr25 1090 11 and and CC cord-024189-t7mbsr25 1090 12 involves involve VBZ cord-024189-t7mbsr25 1090 13 the the DT cord-024189-t7mbsr25 1090 14 small small JJ cord-024189-t7mbsr25 1090 15 leptomeningeal leptomeningeal NN cord-024189-t7mbsr25 1090 16 and and CC cord-024189-t7mbsr25 1090 17 intracerebral intracerebral JJ cord-024189-t7mbsr25 1090 18 arteries artery NNS cord-024189-t7mbsr25 1090 19 . . . cord-024189-t7mbsr25 1091 1 In in IN cord-024189-t7mbsr25 1091 2 general general JJ cord-024189-t7mbsr25 1091 3 , , , cord-024189-t7mbsr25 1091 4 the the DT cord-024189-t7mbsr25 1091 5 arteries artery NNS cord-024189-t7mbsr25 1091 6 are be VBP cord-024189-t7mbsr25 1091 7 involved involve VBN cord-024189-t7mbsr25 1091 8 much much RB cord-024189-t7mbsr25 1091 9 more more RBR cord-024189-t7mbsr25 1091 10 frequently frequently RB cord-024189-t7mbsr25 1091 11 than than IN cord-024189-t7mbsr25 1091 12 the the DT cord-024189-t7mbsr25 1091 13 veins vein NNS cord-024189-t7mbsr25 1091 14 . . . cord-024189-t7mbsr25 1092 1 The the DT cord-024189-t7mbsr25 1092 2 disease disease NN cord-024189-t7mbsr25 1092 3 predominantly predominantly RB cord-024189-t7mbsr25 1092 4 affects affect VBZ cord-024189-t7mbsr25 1092 5 males male NNS cord-024189-t7mbsr25 1092 6 . . . cord-024189-t7mbsr25 1093 1 Most Most JJS cord-024189-t7mbsr25 1093 2 patients patient NNS cord-024189-t7mbsr25 1093 3 are be VBP cord-024189-t7mbsr25 1093 4 young young JJ cord-024189-t7mbsr25 1093 5 or or CC cord-024189-t7mbsr25 1093 6 middle middle JJ cord-024189-t7mbsr25 1093 7 - - HYPH cord-024189-t7mbsr25 1093 8 aged aged JJ cord-024189-t7mbsr25 1093 9 , , , cord-024189-t7mbsr25 1093 10 although although IN cord-024189-t7mbsr25 1093 11 patients patient NNS cord-024189-t7mbsr25 1093 12 of of IN cord-024189-t7mbsr25 1093 13 a a DT cord-024189-t7mbsr25 1093 14 broad broad JJ cord-024189-t7mbsr25 1093 15 age age NN cord-024189-t7mbsr25 1093 16 range range NN cord-024189-t7mbsr25 1093 17 are be VBP cord-024189-t7mbsr25 1093 18 affected affect VBN cord-024189-t7mbsr25 1093 19 . . . cord-024189-t7mbsr25 1094 1 Cases case NNS cord-024189-t7mbsr25 1094 2 of of IN cord-024189-t7mbsr25 1094 3 PACNS PACNS NNP cord-024189-t7mbsr25 1094 4 in in IN cord-024189-t7mbsr25 1094 5 children child NNS cord-024189-t7mbsr25 1094 6 have have VBP cord-024189-t7mbsr25 1094 7 also also RB cord-024189-t7mbsr25 1094 8 been be VBN cord-024189-t7mbsr25 1094 9 described describe VBN cord-024189-t7mbsr25 1094 10 . . . cord-024189-t7mbsr25 1095 1 The the DT cord-024189-t7mbsr25 1095 2 clinical clinical JJ cord-024189-t7mbsr25 1095 3 manifestations manifestation NNS cord-024189-t7mbsr25 1095 4 of of IN cord-024189-t7mbsr25 1095 5 PACNS PACNS NNP cord-024189-t7mbsr25 1095 6 are be VBP cord-024189-t7mbsr25 1095 7 not not RB cord-024189-t7mbsr25 1095 8 distinctive distinctive JJ cord-024189-t7mbsr25 1095 9 . . . cord-024189-t7mbsr25 1096 1 The the DT cord-024189-t7mbsr25 1096 2 most most RBS cord-024189-t7mbsr25 1096 3 common common JJ cord-024189-t7mbsr25 1096 4 symptom symptom NN cord-024189-t7mbsr25 1096 5 is be VBZ cord-024189-t7mbsr25 1096 6 headache headache NN cord-024189-t7mbsr25 1096 7 . . . cord-024189-t7mbsr25 1097 1 Because because IN cord-024189-t7mbsr25 1097 2 virtually virtually RB cord-024189-t7mbsr25 1097 3 every every DT cord-024189-t7mbsr25 1097 4 anatomic anatomic JJ cord-024189-t7mbsr25 1097 5 area area NN cord-024189-t7mbsr25 1097 6 of of IN cord-024189-t7mbsr25 1097 7 the the DT cord-024189-t7mbsr25 1097 8 central central JJ cord-024189-t7mbsr25 1097 9 nervous nervous JJ cord-024189-t7mbsr25 1097 10 system system NN cord-024189-t7mbsr25 1097 11 may may MD cord-024189-t7mbsr25 1097 12 be be VB cord-024189-t7mbsr25 1097 13 affected affect VBN cord-024189-t7mbsr25 1097 14 by by IN cord-024189-t7mbsr25 1097 15 the the DT cord-024189-t7mbsr25 1097 16 vasculitis vasculitis NN cord-024189-t7mbsr25 1097 17 , , , cord-024189-t7mbsr25 1097 18 a a DT cord-024189-t7mbsr25 1097 19 wide wide JJ cord-024189-t7mbsr25 1097 20 range range NN cord-024189-t7mbsr25 1097 21 of of IN cord-024189-t7mbsr25 1097 22 neurologic neurologic JJ cord-024189-t7mbsr25 1097 23 presentations presentation NNS cord-024189-t7mbsr25 1097 24 and and CC cord-024189-t7mbsr25 1097 25 defi defi NNP cord-024189-t7mbsr25 1097 26 cits cits NNP cord-024189-t7mbsr25 1097 27 may may MD cord-024189-t7mbsr25 1097 28 be be VB cord-024189-t7mbsr25 1097 29 seen see VBN cord-024189-t7mbsr25 1097 30 , , , cord-024189-t7mbsr25 1097 31 including include VBG cord-024189-t7mbsr25 1097 32 transient transient JJ cord-024189-t7mbsr25 1097 33 ischemic ischemic JJ cord-024189-t7mbsr25 1097 34 attacks attack NNS cord-024189-t7mbsr25 1097 35 ( ( -LRB- cord-024189-t7mbsr25 1097 36 TIAs tia NNS cord-024189-t7mbsr25 1097 37 ) ) -RRB- cord-024189-t7mbsr25 1097 38 , , , cord-024189-t7mbsr25 1097 39 cerebral cerebral JJ cord-024189-t7mbsr25 1097 40 infarction infarction NN cord-024189-t7mbsr25 1097 41 , , , cord-024189-t7mbsr25 1097 42 paraparesis paraparesis NN cord-024189-t7mbsr25 1097 43 , , , cord-024189-t7mbsr25 1097 44 quadriparesis quadriparesis NNP cord-024189-t7mbsr25 1097 45 , , , cord-024189-t7mbsr25 1097 46 hemiparesis hemiparesis NNP cord-024189-t7mbsr25 1097 47 , , , cord-024189-t7mbsr25 1097 48 ataxia ataxia NN cord-024189-t7mbsr25 1097 49 , , , cord-024189-t7mbsr25 1097 50 seizures seizure NNS cord-024189-t7mbsr25 1097 51 , , , cord-024189-t7mbsr25 1097 52 aphasia aphasia NN cord-024189-t7mbsr25 1097 53 , , , cord-024189-t7mbsr25 1097 54 and and CC cord-024189-t7mbsr25 1097 55 visual visual JJ cord-024189-t7mbsr25 1097 56 fi fi NN cord-024189-t7mbsr25 1097 57 eld eld NN cord-024189-t7mbsr25 1097 58 defects defect NNS cord-024189-t7mbsr25 1097 59 , , , cord-024189-t7mbsr25 1097 60 among among IN cord-024189-t7mbsr25 1097 61 others other NNS cord-024189-t7mbsr25 1097 62 . . . cord-024189-t7mbsr25 1098 1 Decreased decrease VBN cord-024189-t7mbsr25 1098 2 cognitive cognitive JJ cord-024189-t7mbsr25 1098 3 function function NN cord-024189-t7mbsr25 1098 4 or or CC cord-024189-t7mbsr25 1098 5 fl fl JJ cord-024189-t7mbsr25 1098 6 uctuating uctuating NN cord-024189-t7mbsr25 1098 7 levels level NNS cord-024189-t7mbsr25 1098 8 of of IN cord-024189-t7mbsr25 1098 9 consciousness consciousness NN cord-024189-t7mbsr25 1098 10 are be VBP cord-024189-t7mbsr25 1098 11 not not RB cord-024189-t7mbsr25 1098 12 uncommon uncommon JJ cord-024189-t7mbsr25 1098 13 . . . cord-024189-t7mbsr25 1099 1 Progressive progressive JJ cord-024189-t7mbsr25 1099 2 multifocal multifocal JJ cord-024189-t7mbsr25 1099 3 symptoms symptom NNS cord-024189-t7mbsr25 1099 4 over over IN cord-024189-t7mbsr25 1099 5 time time NN cord-024189-t7mbsr25 1099 6 in in IN cord-024189-t7mbsr25 1099 7 a a DT cord-024189-t7mbsr25 1099 8 younger young JJR cord-024189-t7mbsr25 1099 9 patient patient NN cord-024189-t7mbsr25 1099 10 should should MD cord-024189-t7mbsr25 1099 11 suggest suggest VB cord-024189-t7mbsr25 1099 12 the the DT cord-024189-t7mbsr25 1099 13 possibility possibility NN cord-024189-t7mbsr25 1099 14 of of IN cord-024189-t7mbsr25 1099 15 PACNS PACNS NNP cord-024189-t7mbsr25 1099 16 , , , cord-024189-t7mbsr25 1099 17 particularly particularly RB cord-024189-t7mbsr25 1099 18 in in IN cord-024189-t7mbsr25 1099 19 the the DT cord-024189-t7mbsr25 1099 20 absence absence NN cord-024189-t7mbsr25 1099 21 of of IN cord-024189-t7mbsr25 1099 22 other other JJ cord-024189-t7mbsr25 1099 23 risk risk NN cord-024189-t7mbsr25 1099 24 factors factor NNS cord-024189-t7mbsr25 1099 25 . . . cord-024189-t7mbsr25 1100 1 The the DT cord-024189-t7mbsr25 1100 2 spinal spinal JJ cord-024189-t7mbsr25 1100 3 cord cord NN cord-024189-t7mbsr25 1100 4 may may MD cord-024189-t7mbsr25 1100 5 occasionally occasionally RB cord-024189-t7mbsr25 1100 6 be be VB cord-024189-t7mbsr25 1100 7 involved involve VBN cord-024189-t7mbsr25 1100 8 . . . cord-024189-t7mbsr25 1101 1 Presentations presentation NNS cord-024189-t7mbsr25 1101 2 with with IN cord-024189-t7mbsr25 1101 3 subarachnoid subarachnoid NN cord-024189-t7mbsr25 1101 4 or or CC cord-024189-t7mbsr25 1101 5 intracerebral intracerebral JJ cord-024189-t7mbsr25 1101 6 hemorrhage hemorrhage NN cord-024189-t7mbsr25 1101 7 are be VBP cord-024189-t7mbsr25 1101 8 rare rare JJ cord-024189-t7mbsr25 1101 9 . . . cord-024189-t7mbsr25 1102 1 Timely timely JJ cord-024189-t7mbsr25 1102 2 diagnosis diagnosis NN cord-024189-t7mbsr25 1102 3 of of IN cord-024189-t7mbsr25 1102 4 PACNS PACNS NNP cord-024189-t7mbsr25 1102 5 is be VBZ cord-024189-t7mbsr25 1102 6 critical critical JJ cord-024189-t7mbsr25 1102 7 , , , cord-024189-t7mbsr25 1102 8 before before IN cord-024189-t7mbsr25 1102 9 the the DT cord-024189-t7mbsr25 1102 10 occurrence occurrence NN cord-024189-t7mbsr25 1102 11 of of IN cord-024189-t7mbsr25 1102 12 massive massive JJ cord-024189-t7mbsr25 1102 13 brain brain NN cord-024189-t7mbsr25 1102 14 damage damage NN cord-024189-t7mbsr25 1102 15 . . . cord-024189-t7mbsr25 1103 1 Preliminary preliminary JJ cord-024189-t7mbsr25 1103 2 diagnostic diagnostic JJ cord-024189-t7mbsr25 1103 3 criteria criterion NNS cord-024189-t7mbsr25 1103 4 for for IN cord-024189-t7mbsr25 1103 5 PACNS PACNS NNP cord-024189-t7mbsr25 1103 6 have have VBP cord-024189-t7mbsr25 1103 7 been be VBN cord-024189-t7mbsr25 1103 8 proposed propose VBN cord-024189-t7mbsr25 1103 9 ( ( -LRB- cord-024189-t7mbsr25 1103 10 18 18 CD cord-024189-t7mbsr25 1103 11 ) ) -RRB- cord-024189-t7mbsr25 1103 12 but but CC cord-024189-t7mbsr25 1103 13 never never RB cord-024189-t7mbsr25 1103 14 validated validate VBD cord-024189-t7mbsr25 1103 15 . . . cord-024189-t7mbsr25 1104 1 The the DT cord-024189-t7mbsr25 1104 2 diagnosis diagnosis NN cord-024189-t7mbsr25 1104 3 of of IN cord-024189-t7mbsr25 1104 4 PACNS PACNS NNP cord-024189-t7mbsr25 1104 5 is be VBZ cord-024189-t7mbsr25 1104 6 usually usually RB cord-024189-t7mbsr25 1104 7 predicated predicate VBN cord-024189-t7mbsr25 1104 8 upon upon IN cord-024189-t7mbsr25 1104 9 either either CC cord-024189-t7mbsr25 1104 10 biopsy biopsy JJ cord-024189-t7mbsr25 1104 11 evidence evidence NN cord-024189-t7mbsr25 1104 12 of of IN cord-024189-t7mbsr25 1104 13 vasculitis vasculitis NN cord-024189-t7mbsr25 1104 14 or or CC cord-024189-t7mbsr25 1104 15 angiographic angiographic JJ cord-024189-t7mbsr25 1104 16 fi fi NN cord-024189-t7mbsr25 1104 17 ndings nding NNS cord-024189-t7mbsr25 1104 18 suggestive suggestive JJ cord-024189-t7mbsr25 1104 19 of of IN cord-024189-t7mbsr25 1104 20 vasculitis vasculitis NN cord-024189-t7mbsr25 1104 21 in in IN cord-024189-t7mbsr25 1104 22 the the DT cord-024189-t7mbsr25 1104 23 setting setting NN cord-024189-t7mbsr25 1104 24 of of IN cord-024189-t7mbsr25 1104 25 other other JJ cord-024189-t7mbsr25 1104 26 compelling compelling JJ cord-024189-t7mbsr25 1104 27 features feature NNS cord-024189-t7mbsr25 1104 28 , , , cord-024189-t7mbsr25 1104 29 for for IN cord-024189-t7mbsr25 1104 30 example example NN cord-024189-t7mbsr25 1104 31 , , , cord-024189-t7mbsr25 1104 32 strokes stroke NNS cord-024189-t7mbsr25 1104 33 demonstrated demonstrate VBN cord-024189-t7mbsr25 1104 34 by by IN cord-024189-t7mbsr25 1104 35 magnetic magnetic JJ cord-024189-t7mbsr25 1104 36 resonance resonance NN cord-024189-t7mbsr25 1104 37 imaging imaging NN cord-024189-t7mbsr25 1104 38 or or CC cord-024189-t7mbsr25 1104 39 the the DT cord-024189-t7mbsr25 1104 40 fi fi NNP cord-024189-t7mbsr25 1104 41 ndings nding NNS cord-024189-t7mbsr25 1104 42 of of IN cord-024189-t7mbsr25 1104 43 a a DT cord-024189-t7mbsr25 1104 44 cerebrospinal cerebrospinal JJ cord-024189-t7mbsr25 1104 45 fl fl NNP cord-024189-t7mbsr25 1104 46 uid uid NNP cord-024189-t7mbsr25 1104 47 pleocytosis pleocytosis NNP cord-024189-t7mbsr25 1104 48 ( ( -LRB- cord-024189-t7mbsr25 1104 49 17 17 CD cord-024189-t7mbsr25 1104 50 ) ) -RRB- cord-024189-t7mbsr25 1104 51 . . . cord-024189-t7mbsr25 1105 1 Histologic Histologic NNP cord-024189-t7mbsr25 1105 2 confi confi NNP cord-024189-t7mbsr25 1105 3 rmation rmation NN cord-024189-t7mbsr25 1105 4 remains remain VBZ cord-024189-t7mbsr25 1105 5 the the DT cord-024189-t7mbsr25 1105 6 most most RBS cord-024189-t7mbsr25 1105 7 specifi specifi JJ cord-024189-t7mbsr25 1105 8 c c NN cord-024189-t7mbsr25 1105 9 diagnostic diagnostic JJ cord-024189-t7mbsr25 1105 10 procedure procedure NN cord-024189-t7mbsr25 1105 11 for for IN cord-024189-t7mbsr25 1105 12 PACNS PACNS NNP cord-024189-t7mbsr25 1105 13 , , , cord-024189-t7mbsr25 1105 14 but but CC cord-024189-t7mbsr25 1105 15 the the DT cord-024189-t7mbsr25 1105 16 sensitivity sensitivity NN cord-024189-t7mbsr25 1105 17 of of IN cord-024189-t7mbsr25 1105 18 brain brain NN cord-024189-t7mbsr25 1105 19 biopsy biopsy NN cord-024189-t7mbsr25 1105 20 is be VBZ cord-024189-t7mbsr25 1105 21 limited limit VBN cord-024189-t7mbsr25 1105 22 because because IN cord-024189-t7mbsr25 1105 23 of of IN cord-024189-t7mbsr25 1105 24 the the DT cord-024189-t7mbsr25 1105 25 focal focal JJ cord-024189-t7mbsr25 1105 26 segmental segmental JJ cord-024189-t7mbsr25 1105 27 distribution distribution NN cord-024189-t7mbsr25 1105 28 of of IN cord-024189-t7mbsr25 1105 29 the the DT cord-024189-t7mbsr25 1105 30 disease disease NN cord-024189-t7mbsr25 1105 31 . . . cord-024189-t7mbsr25 1106 1 A a DT cord-024189-t7mbsr25 1106 2 negative negative JJ cord-024189-t7mbsr25 1106 3 biopsy biopsy NN cord-024189-t7mbsr25 1106 4 does do VBZ cord-024189-t7mbsr25 1106 5 not not RB cord-024189-t7mbsr25 1106 6 exclude exclude VB cord-024189-t7mbsr25 1106 7 the the DT cord-024189-t7mbsr25 1106 8 diagnosis diagnosis NN cord-024189-t7mbsr25 1106 9 of of IN cord-024189-t7mbsr25 1106 10 PACNS PACNS NNP cord-024189-t7mbsr25 1106 11 , , , cord-024189-t7mbsr25 1106 12 but but CC cord-024189-t7mbsr25 1106 13 may may MD cord-024189-t7mbsr25 1106 14 be be VB cord-024189-t7mbsr25 1106 15 essential essential JJ cord-024189-t7mbsr25 1106 16 to to IN cord-024189-t7mbsr25 1106 17 excluding exclude VBG cord-024189-t7mbsr25 1106 18 other other JJ cord-024189-t7mbsr25 1106 19 disorders disorder NNS cord-024189-t7mbsr25 1106 20 that that WDT cord-024189-t7mbsr25 1106 21 mimic mimic VBP cord-024189-t7mbsr25 1106 22 PACNS PACNS NNP cord-024189-t7mbsr25 1106 23 clinically clinically RB cord-024189-t7mbsr25 1106 24 . . . cord-024189-t7mbsr25 1107 1 In in IN cord-024189-t7mbsr25 1107 2 the the DT cord-024189-t7mbsr25 1107 3 absence absence NN cord-024189-t7mbsr25 1107 4 of of IN cord-024189-t7mbsr25 1107 5 histologic histologic JJ cord-024189-t7mbsr25 1107 6 confi confi NN cord-024189-t7mbsr25 1107 7 rmation rmation NN cord-024189-t7mbsr25 1107 8 , , , cord-024189-t7mbsr25 1107 9 a a DT cord-024189-t7mbsr25 1107 10 cerebral cerebral JJ cord-024189-t7mbsr25 1107 11 angiogram angiogram NN cord-024189-t7mbsr25 1107 12 typical typical JJ cord-024189-t7mbsr25 1107 13 of of IN cord-024189-t7mbsr25 1107 14 vasculitis vasculitis NN cord-024189-t7mbsr25 1107 15 in in IN cord-024189-t7mbsr25 1107 16 the the DT cord-024189-t7mbsr25 1107 17 appropriate appropriate JJ cord-024189-t7mbsr25 1107 18 clinical clinical JJ cord-024189-t7mbsr25 1107 19 settings setting NNS cord-024189-t7mbsr25 1107 20 is be VBZ cord-024189-t7mbsr25 1107 21 frequently frequently RB cord-024189-t7mbsr25 1107 22 used use VBN cord-024189-t7mbsr25 1107 23 to to TO cord-024189-t7mbsr25 1107 24 establish establish VB cord-024189-t7mbsr25 1107 25 the the DT cord-024189-t7mbsr25 1107 26 diagnosis diagnosis NN cord-024189-t7mbsr25 1107 27 of of IN cord-024189-t7mbsr25 1107 28 PACNS PACNS NNP cord-024189-t7mbsr25 1107 29 . . . cord-024189-t7mbsr25 1108 1 Suggestive suggestive JJ cord-024189-t7mbsr25 1108 2 angiographic angiographic JJ cord-024189-t7mbsr25 1108 3 fi fi NN cord-024189-t7mbsr25 1108 4 ndings nding NNS cord-024189-t7mbsr25 1108 5 include include VBP cord-024189-t7mbsr25 1108 6 segmental segmental JJ cord-024189-t7mbsr25 1108 7 narrowing narrowing NN cord-024189-t7mbsr25 1108 8 , , , cord-024189-t7mbsr25 1108 9 dilatation dilatation NN cord-024189-t7mbsr25 1108 10 , , , cord-024189-t7mbsr25 1108 11 or or CC cord-024189-t7mbsr25 1108 12 occlusion occlusion NN cord-024189-t7mbsr25 1108 13 affecting affect VBG cord-024189-t7mbsr25 1108 14 multiple multiple JJ cord-024189-t7mbsr25 1108 15 cerebral cerebral JJ cord-024189-t7mbsr25 1108 16 arteries artery NNS cord-024189-t7mbsr25 1108 17 in in IN cord-024189-t7mbsr25 1108 18 the the DT cord-024189-t7mbsr25 1108 19 absence absence NN cord-024189-t7mbsr25 1108 20 of of IN cord-024189-t7mbsr25 1108 21 proximal proximal JJ cord-024189-t7mbsr25 1108 22 atherosclerotic atherosclerotic JJ cord-024189-t7mbsr25 1108 23 changes change NNS cord-024189-t7mbsr25 1108 24 ( ( -LRB- cord-024189-t7mbsr25 1108 25 Figure figure NN cord-024189-t7mbsr25 1108 26 21E-5 21e-5 CD cord-024189-t7mbsr25 1108 27 ) ) -RRB- cord-024189-t7mbsr25 1108 28 . . . cord-024189-t7mbsr25 1109 1 The the DT cord-024189-t7mbsr25 1109 2 fi fi NN cord-024189-t7mbsr25 1109 3 ndings nding NNS cord-024189-t7mbsr25 1109 4 of of IN cord-024189-t7mbsr25 1109 5 narrowing narrow VBG cord-024189-t7mbsr25 1109 6 are be VBP cord-024189-t7mbsr25 1109 7 , , , cord-024189-t7mbsr25 1109 8 however however RB cord-024189-t7mbsr25 1109 9 , , , cord-024189-t7mbsr25 1109 10 highly highly RB cord-024189-t7mbsr25 1109 11 nonspecifi nonspecifi JJ cord-024189-t7mbsr25 1109 12 c c NN cord-024189-t7mbsr25 1109 13 , , , cord-024189-t7mbsr25 1109 14 and and CC cord-024189-t7mbsr25 1109 15 can can MD cord-024189-t7mbsr25 1109 16 be be VB cord-024189-t7mbsr25 1109 17 caused cause VBN cord-024189-t7mbsr25 1109 18 by by IN cord-024189-t7mbsr25 1109 19 a a DT cord-024189-t7mbsr25 1109 20 host host NN cord-024189-t7mbsr25 1109 21 of of IN cord-024189-t7mbsr25 1109 22 nonvasculitic nonvasculitic JJ cord-024189-t7mbsr25 1109 23 causes cause NNS cord-024189-t7mbsr25 1109 24 . . . cord-024189-t7mbsr25 1110 1 Angiographic angiographic JJ cord-024189-t7mbsr25 1110 2 fi fi IN cord-024189-t7mbsr25 1110 3 ndings nding NNS cord-024189-t7mbsr25 1110 4 compatible compatible JJ cord-024189-t7mbsr25 1110 5 with with IN cord-024189-t7mbsr25 1110 6 vasculitis vasculitis NN cord-024189-t7mbsr25 1110 7 are be VBP cord-024189-t7mbsr25 1110 8 commonly commonly RB cord-024189-t7mbsr25 1110 9 encountered encounter VBN cord-024189-t7mbsr25 1110 10 in in IN cord-024189-t7mbsr25 1110 11 conditions condition NNS cord-024189-t7mbsr25 1110 12 such such JJ cord-024189-t7mbsr25 1110 13 as as IN cord-024189-t7mbsr25 1110 14 vasospasm vasospasm NN cord-024189-t7mbsr25 1110 15 , , , cord-024189-t7mbsr25 1110 16 central central JJ cord-024189-t7mbsr25 1110 17 nervous nervous JJ cord-024189-t7mbsr25 1110 18 system system NN cord-024189-t7mbsr25 1110 19 infection infection NN cord-024189-t7mbsr25 1110 20 , , , cord-024189-t7mbsr25 1110 21 cerebral cerebral JJ cord-024189-t7mbsr25 1110 22 arterial arterial JJ cord-024189-t7mbsr25 1110 23 emboli emboli NN cord-024189-t7mbsr25 1110 24 , , , cord-024189-t7mbsr25 1110 25 intravascular intravascular JJ cord-024189-t7mbsr25 1110 26 lymphomatosis lymphomatosis NN cord-024189-t7mbsr25 1110 27 , , , cord-024189-t7mbsr25 1110 28 and and CC cord-024189-t7mbsr25 1110 29 atherosclerosis atherosclerosis NN cord-024189-t7mbsr25 1110 30 . . . cord-024189-t7mbsr25 1111 1 Furthermore furthermore RB cord-024189-t7mbsr25 1111 2 , , , cord-024189-t7mbsr25 1111 3 the the DT cord-024189-t7mbsr25 1111 4 sensitivity sensitivity NN cord-024189-t7mbsr25 1111 5 of of IN cord-024189-t7mbsr25 1111 6 angiography angiography NN cord-024189-t7mbsr25 1111 7 is be VBZ cord-024189-t7mbsr25 1111 8 limited limit VBN cord-024189-t7mbsr25 1111 9 if if IN cord-024189-t7mbsr25 1111 10 small small JJ cord-024189-t7mbsr25 1111 11 vessels vessel NNS cord-024189-t7mbsr25 1111 12 beyond beyond IN cord-024189-t7mbsr25 1111 13 its -PRON- PRP$ cord-024189-t7mbsr25 1111 14 resolution resolution NN cord-024189-t7mbsr25 1111 15 are be VBP cord-024189-t7mbsr25 1111 16 primarily primarily RB cord-024189-t7mbsr25 1111 17 involved involve VBN cord-024189-t7mbsr25 1111 18 . . . cord-024189-t7mbsr25 1112 1 Cerebral cerebral JJ cord-024189-t7mbsr25 1112 2 angiography angiography NN cord-024189-t7mbsr25 1112 3 has have VBZ cord-024189-t7mbsr25 1112 4 been be VBN cord-024189-t7mbsr25 1112 5 normal normal JJ cord-024189-t7mbsr25 1112 6 in in IN cord-024189-t7mbsr25 1112 7 some some DT cord-024189-t7mbsr25 1112 8 biopsy biopsy NN cord-024189-t7mbsr25 1112 9 - - HYPH cord-024189-t7mbsr25 1112 10 proven prove VBN cord-024189-t7mbsr25 1112 11 cases case NNS cord-024189-t7mbsr25 1112 12 . . . cord-024189-t7mbsr25 1113 1 General general JJ cord-024189-t7mbsr25 1113 2 laboratory laboratory NN cord-024189-t7mbsr25 1113 3 tests test NNS cord-024189-t7mbsr25 1113 4 , , , cord-024189-t7mbsr25 1113 5 including include VBG cord-024189-t7mbsr25 1113 6 acute acute JJ cord-024189-t7mbsr25 1113 7 - - HYPH cord-024189-t7mbsr25 1113 8 phase phase NN cord-024189-t7mbsr25 1113 9 reactants reactant NNS cord-024189-t7mbsr25 1113 10 such such JJ cord-024189-t7mbsr25 1113 11 as as IN cord-024189-t7mbsr25 1113 12 C C NNP cord-024189-t7mbsr25 1113 13 - - HYPH cord-024189-t7mbsr25 1113 14 reactive reactive JJ cord-024189-t7mbsr25 1113 15 protein protein NN cord-024189-t7mbsr25 1113 16 and and CC cord-024189-t7mbsr25 1113 17 the the DT cord-024189-t7mbsr25 1113 18 erythrocyte erythrocyte NN cord-024189-t7mbsr25 1113 19 sedimentation sedimentation NN cord-024189-t7mbsr25 1113 20 rate rate NN cord-024189-t7mbsr25 1113 21 , , , cord-024189-t7mbsr25 1113 22 are be VBP cord-024189-t7mbsr25 1113 23 not not RB cord-024189-t7mbsr25 1113 24 useful useful JJ cord-024189-t7mbsr25 1113 25 in in IN cord-024189-t7mbsr25 1113 26 the the DT cord-024189-t7mbsr25 1113 27 diagnosis diagnosis NN cord-024189-t7mbsr25 1113 28 of of IN cord-024189-t7mbsr25 1113 29 PACNS PACNS NNP cord-024189-t7mbsr25 1113 30 . . . cord-024189-t7mbsr25 1114 1 In in IN cord-024189-t7mbsr25 1114 2 addition addition NN cord-024189-t7mbsr25 1114 3 to to IN cord-024189-t7mbsr25 1114 4 being be VBG cord-024189-t7mbsr25 1114 5 nonspecifi nonspecifi NNP cord-024189-t7mbsr25 1114 6 c c NN cord-024189-t7mbsr25 1114 7 , , , cord-024189-t7mbsr25 1114 8 in in IN cord-024189-t7mbsr25 1114 9 fact fact NN cord-024189-t7mbsr25 1114 10 , , , cord-024189-t7mbsr25 1114 11 acutephase acutephase NN cord-024189-t7mbsr25 1114 12 reactants reactant NNS cord-024189-t7mbsr25 1114 13 are be VBP cord-024189-t7mbsr25 1114 14 known know VBN cord-024189-t7mbsr25 1114 15 often often RB cord-024189-t7mbsr25 1114 16 to to TO cord-024189-t7mbsr25 1114 17 be be VB cord-024189-t7mbsr25 1114 18 normal normal JJ cord-024189-t7mbsr25 1114 19 even even RB cord-024189-t7mbsr25 1114 20 in in IN cord-024189-t7mbsr25 1114 21 the the DT cord-024189-t7mbsr25 1114 22 setting setting NN cord-024189-t7mbsr25 1114 23 of of IN cord-024189-t7mbsr25 1114 24 biopsy biopsy NN cord-024189-t7mbsr25 1114 25 - - HYPH cord-024189-t7mbsr25 1114 26 proven prove VBN cord-024189-t7mbsr25 1114 27 active active JJ cord-024189-t7mbsr25 1114 28 disease disease NN cord-024189-t7mbsr25 1114 29 . . . cord-024189-t7mbsr25 1115 1 Cerebrospinal cerebrospinal NN cord-024189-t7mbsr25 1115 2 fl fl NNP cord-024189-t7mbsr25 1115 3 uid uid NN cord-024189-t7mbsr25 1115 4 ( ( -LRB- cord-024189-t7mbsr25 1115 5 CSF CSF NNP cord-024189-t7mbsr25 1115 6 ) ) -RRB- cord-024189-t7mbsr25 1115 7 analysis analysis NN cord-024189-t7mbsr25 1115 8 , , , cord-024189-t7mbsr25 1115 9 however however RB cord-024189-t7mbsr25 1115 10 , , , cord-024189-t7mbsr25 1115 11 is be VBZ cord-024189-t7mbsr25 1115 12 an an DT cord-024189-t7mbsr25 1115 13 essential essential JJ cord-024189-t7mbsr25 1115 14 part part NN cord-024189-t7mbsr25 1115 15 of of IN cord-024189-t7mbsr25 1115 16 the the DT cord-024189-t7mbsr25 1115 17 diagnostic diagnostic JJ cord-024189-t7mbsr25 1115 18 workup workup NN cord-024189-t7mbsr25 1115 19 of of IN cord-024189-t7mbsr25 1115 20 PACNS PACNS NNP cord-024189-t7mbsr25 1115 21 . . . cord-024189-t7mbsr25 1116 1 The the DT cord-024189-t7mbsr25 1116 2 CSF CSF NNP cord-024189-t7mbsr25 1116 3 fi fi NN cord-024189-t7mbsr25 1116 4 ndings nding NNS cord-024189-t7mbsr25 1116 5 are be VBP cord-024189-t7mbsr25 1116 6 abnormal abnormal JJ cord-024189-t7mbsr25 1116 7 in in IN cord-024189-t7mbsr25 1116 8 80 80 CD cord-024189-t7mbsr25 1116 9 % % NN cord-024189-t7mbsr25 1116 10 to to TO cord-024189-t7mbsr25 1116 11 90 90 CD cord-024189-t7mbsr25 1116 12 % % NN cord-024189-t7mbsr25 1116 13 of of IN cord-024189-t7mbsr25 1116 14 cases case NNS cord-024189-t7mbsr25 1116 15 documented document VBN cord-024189-t7mbsr25 1116 16 pathologically pathologically RB cord-024189-t7mbsr25 1116 17 . . . cord-024189-t7mbsr25 1117 1 CSF CSF NNP cord-024189-t7mbsr25 1117 2 fi fi IN cord-024189-t7mbsr25 1117 3 ndings nding NNS cord-024189-t7mbsr25 1117 4 are be VBP cord-024189-t7mbsr25 1117 5 characterized characterize VBN cord-024189-t7mbsr25 1117 6 by by IN cord-024189-t7mbsr25 1117 7 a a DT cord-024189-t7mbsr25 1117 8 modest modest JJ cord-024189-t7mbsr25 1117 9 pleocytosis pleocytosis NN cord-024189-t7mbsr25 1117 10 and and CC cord-024189-t7mbsr25 1117 11 elevated elevated JJ cord-024189-t7mbsr25 1117 12 protein protein NN cord-024189-t7mbsr25 1117 13 levels level NNS cord-024189-t7mbsr25 1117 14 . . . cord-024189-t7mbsr25 1118 1 CSF CSF NNP cord-024189-t7mbsr25 1118 2 analysis analysis NN cord-024189-t7mbsr25 1118 3 should should MD cord-024189-t7mbsr25 1118 4 include include VB cord-024189-t7mbsr25 1118 5 appropriate appropriate JJ cord-024189-t7mbsr25 1118 6 stains stain NNS cord-024189-t7mbsr25 1118 7 , , , cord-024189-t7mbsr25 1118 8 cultures culture NNS cord-024189-t7mbsr25 1118 9 , , , cord-024189-t7mbsr25 1118 10 and and CC cord-024189-t7mbsr25 1118 11 serologic serologic JJ cord-024189-t7mbsr25 1118 12 tests test NNS cord-024189-t7mbsr25 1118 13 to to TO cord-024189-t7mbsr25 1118 14 exclude exclude VB cord-024189-t7mbsr25 1118 15 for for IN cord-024189-t7mbsr25 1118 16 CNS CNS NNP cord-024189-t7mbsr25 1118 17 infections infection NNS cord-024189-t7mbsr25 1118 18 . . . cord-024189-t7mbsr25 1119 1 Magnetic magnetic JJ cord-024189-t7mbsr25 1119 2 resonance resonance NN cord-024189-t7mbsr25 1119 3 imaging imaging NN cord-024189-t7mbsr25 1119 4 ( ( -LRB- cord-024189-t7mbsr25 1119 5 MRI MRI NNP cord-024189-t7mbsr25 1119 6 ) ) -RRB- cord-024189-t7mbsr25 1119 7 is be VBZ cord-024189-t7mbsr25 1119 8 the the DT cord-024189-t7mbsr25 1119 9 most most RBS cord-024189-t7mbsr25 1119 10 sensitive sensitive JJ cord-024189-t7mbsr25 1119 11 imaging imaging NN cord-024189-t7mbsr25 1119 12 study study NN cord-024189-t7mbsr25 1119 13 in in IN cord-024189-t7mbsr25 1119 14 the the DT cord-024189-t7mbsr25 1119 15 evaluation evaluation NN cord-024189-t7mbsr25 1119 16 of of IN cord-024189-t7mbsr25 1119 17 PACNS PACNS NNP cord-024189-t7mbsr25 1119 18 . . . cord-024189-t7mbsr25 1120 1 Only only RB cord-024189-t7mbsr25 1120 2 rare rare JJ cord-024189-t7mbsr25 1120 3 cases case NNS cord-024189-t7mbsr25 1120 4 have have VBP cord-024189-t7mbsr25 1120 5 no no DT cord-024189-t7mbsr25 1120 6 MRI MRI NNP cord-024189-t7mbsr25 1120 7 abnormalities abnormality NNS cord-024189-t7mbsr25 1120 8 . . . cord-024189-t7mbsr25 1121 1 The the DT cord-024189-t7mbsr25 1121 2 most most RBS cord-024189-t7mbsr25 1121 3 common common JJ cord-024189-t7mbsr25 1121 4 fi fi NN cord-024189-t7mbsr25 1121 5 ndings nding NNS cord-024189-t7mbsr25 1121 6 are be VBP cord-024189-t7mbsr25 1121 7 multiple multiple JJ cord-024189-t7mbsr25 1121 8 , , , cord-024189-t7mbsr25 1121 9 bilateral bilateral JJ cord-024189-t7mbsr25 1121 10 , , , cord-024189-t7mbsr25 1121 11 supratentorial supratentorial JJ cord-024189-t7mbsr25 1121 12 infarcts infarct NNS cord-024189-t7mbsr25 1121 13 distributed distribute VBN cord-024189-t7mbsr25 1121 14 in in IN cord-024189-t7mbsr25 1121 15 the the DT cord-024189-t7mbsr25 1121 16 cortex cortex NN cord-024189-t7mbsr25 1121 17 , , , cord-024189-t7mbsr25 1121 18 deep deep JJ cord-024189-t7mbsr25 1121 19 white white JJ cord-024189-t7mbsr25 1121 20 matter matter NN cord-024189-t7mbsr25 1121 21 , , , cord-024189-t7mbsr25 1121 22 and/or and/or CC cord-024189-t7mbsr25 1121 23 leptomeninges leptomeninges NNP cord-024189-t7mbsr25 1121 24 , , , cord-024189-t7mbsr25 1121 25 but but CC cord-024189-t7mbsr25 1121 26 the the DT cord-024189-t7mbsr25 1121 27 fi fi NNP cord-024189-t7mbsr25 1121 28 ndings nding NNS cord-024189-t7mbsr25 1121 29 lack lack VBP cord-024189-t7mbsr25 1121 30 specifi specifi NNP cord-024189-t7mbsr25 1121 31 city city NN cord-024189-t7mbsr25 1121 32 . . . cord-024189-t7mbsr25 1122 1 Magnetic magnetic JJ cord-024189-t7mbsr25 1122 2 resonance resonance NN cord-024189-t7mbsr25 1122 3 angiography angiography NN cord-024189-t7mbsr25 1122 4 ( ( -LRB- cord-024189-t7mbsr25 1122 5 MRA MRA NNP cord-024189-t7mbsr25 1122 6 ) ) -RRB- cord-024189-t7mbsr25 1122 7 is be VBZ cord-024189-t7mbsr25 1122 8 limited limit VBN cord-024189-t7mbsr25 1122 9 in in IN cord-024189-t7mbsr25 1122 10 sensitivity sensitivity NN cord-024189-t7mbsr25 1122 11 in in IN cord-024189-t7mbsr25 1122 12 most most JJS cord-024189-t7mbsr25 1122 13 cases case NNS cord-024189-t7mbsr25 1122 14 of of IN cord-024189-t7mbsr25 1122 15 PACNS PACNS NNP cord-024189-t7mbsr25 1122 16 . . . cord-024189-t7mbsr25 1123 1 Angiographically angiographically JJ cord-024189-t7mbsr25 1123 2 demonstrable demonstrable JJ cord-024189-t7mbsr25 1123 3 lesions lesion NNS cord-024189-t7mbsr25 1123 4 are be VBP cord-024189-t7mbsr25 1123 5 often often RB cord-024189-t7mbsr25 1123 6 beyond beyond IN cord-024189-t7mbsr25 1123 7 the the DT cord-024189-t7mbsr25 1123 8 resolution resolution NN cord-024189-t7mbsr25 1123 9 of of IN cord-024189-t7mbsr25 1123 10 current current JJ cord-024189-t7mbsr25 1123 11 MRA MRA NNP cord-024189-t7mbsr25 1123 12 technology technology NN cord-024189-t7mbsr25 1123 13 . . . cord-024189-t7mbsr25 1124 1 Thus thus RB cord-024189-t7mbsr25 1124 2 , , , cord-024189-t7mbsr25 1124 3 a a DT cord-024189-t7mbsr25 1124 4 normal normal JJ cord-024189-t7mbsr25 1124 5 MRA MRA NNP cord-024189-t7mbsr25 1124 6 does do VBZ cord-024189-t7mbsr25 1124 7 not not RB cord-024189-t7mbsr25 1124 8 rule rule VB cord-024189-t7mbsr25 1124 9 out out RP cord-024189-t7mbsr25 1124 10 the the DT cord-024189-t7mbsr25 1124 11 disorder disorder NN cord-024189-t7mbsr25 1124 12 . . . cord-024189-t7mbsr25 1125 1 Primary primary JJ cord-024189-t7mbsr25 1125 2 angiitis angiitis RB cord-024189-t7mbsr25 1125 3 of of IN cord-024189-t7mbsr25 1125 4 the the DT cord-024189-t7mbsr25 1125 5 central central JJ cord-024189-t7mbsr25 1125 6 nervous nervous JJ cord-024189-t7mbsr25 1125 7 system system NN cord-024189-t7mbsr25 1125 8 is be VBZ cord-024189-t7mbsr25 1125 9 considered consider VBN cord-024189-t7mbsr25 1125 10 a a DT cord-024189-t7mbsr25 1125 11 progressive progressive JJ cord-024189-t7mbsr25 1125 12 disorder disorder NN cord-024189-t7mbsr25 1125 13 with with IN cord-024189-t7mbsr25 1125 14 a a DT cord-024189-t7mbsr25 1125 15 fatal fatal JJ cord-024189-t7mbsr25 1125 16 course course NN cord-024189-t7mbsr25 1125 17 unless unless IN cord-024189-t7mbsr25 1125 18 treated treat VBN cord-024189-t7mbsr25 1125 19 vigorously vigorously RB cord-024189-t7mbsr25 1125 20 with with IN cord-024189-t7mbsr25 1125 21 a a DT cord-024189-t7mbsr25 1125 22 combination combination NN cord-024189-t7mbsr25 1125 23 of of IN cord-024189-t7mbsr25 1125 24 high high JJ cord-024189-t7mbsr25 1125 25 - - HYPH cord-024189-t7mbsr25 1125 26 dose dose NN cord-024189-t7mbsr25 1125 27 glucocorticoids glucocorticoid NNS cord-024189-t7mbsr25 1125 28 and and CC cord-024189-t7mbsr25 1125 29 a a DT cord-024189-t7mbsr25 1125 30 cytotoxic cytotoxic JJ cord-024189-t7mbsr25 1125 31 agent agent NN cord-024189-t7mbsr25 1125 32 ( ( -LRB- cord-024189-t7mbsr25 1125 33 usually usually RB cord-024189-t7mbsr25 1125 34 cyclophos- cyclophos- VBN cord-024189-t7mbsr25 1125 35 Cerebral cerebral JJ cord-024189-t7mbsr25 1125 36 angiogram angiogram NN cord-024189-t7mbsr25 1125 37 in in IN cord-024189-t7mbsr25 1125 38 a a DT cord-024189-t7mbsr25 1125 39 patient patient NN cord-024189-t7mbsr25 1125 40 with with IN cord-024189-t7mbsr25 1125 41 central central JJ cord-024189-t7mbsr25 1125 42 nervous nervous JJ cord-024189-t7mbsr25 1125 43 system system NN cord-024189-t7mbsr25 1125 44 vasculitis vasculitis NN cord-024189-t7mbsr25 1125 45 . . . cord-024189-t7mbsr25 1126 1 The the DT cord-024189-t7mbsr25 1126 2 angiogram angiogram NN cord-024189-t7mbsr25 1126 3 reveals reveal VBZ cord-024189-t7mbsr25 1126 4 multiple multiple JJ cord-024189-t7mbsr25 1126 5 segmental segmental JJ cord-024189-t7mbsr25 1126 6 stenoses stenosis NNS cord-024189-t7mbsr25 1126 7 of of IN cord-024189-t7mbsr25 1126 8 the the DT cord-024189-t7mbsr25 1126 9 A1 A1 NNP cord-024189-t7mbsr25 1126 10 and and CC cord-024189-t7mbsr25 1126 11 A2 A2 NNP cord-024189-t7mbsr25 1126 12 segments segment NNS cord-024189-t7mbsr25 1126 13 of of IN cord-024189-t7mbsr25 1126 14 the the DT cord-024189-t7mbsr25 1126 15 anterior anterior JJ cord-024189-t7mbsr25 1126 16 cerebral cerebral JJ cord-024189-t7mbsr25 1126 17 artery artery NN cord-024189-t7mbsr25 1126 18 and and CC cord-024189-t7mbsr25 1126 19 the the DT cord-024189-t7mbsr25 1126 20 distal distal JJ cord-024189-t7mbsr25 1126 21 segments segment NNS cord-024189-t7mbsr25 1126 22 of of IN cord-024189-t7mbsr25 1126 23 the the DT cord-024189-t7mbsr25 1126 24 middle middle JJ cord-024189-t7mbsr25 1126 25 cerebral cerebral JJ cord-024189-t7mbsr25 1126 26 artery artery NN cord-024189-t7mbsr25 1126 27 . . . cord-024189-t7mbsr25 1127 1 phamide phamide NNP cord-024189-t7mbsr25 1127 2 ) ) -RRB- cord-024189-t7mbsr25 1127 3 . . . cord-024189-t7mbsr25 1128 1 There there EX cord-024189-t7mbsr25 1128 2 are be VBP cord-024189-t7mbsr25 1128 3 no no DT cord-024189-t7mbsr25 1128 4 controlled control VBN cord-024189-t7mbsr25 1128 5 treatment treatment NN cord-024189-t7mbsr25 1128 6 trials trial NNS cord-024189-t7mbsr25 1128 7 on on IN cord-024189-t7mbsr25 1128 8 which which WDT cord-024189-t7mbsr25 1128 9 to to TO cord-024189-t7mbsr25 1128 10 base base VB cord-024189-t7mbsr25 1128 11 this this DT cord-024189-t7mbsr25 1128 12 standard standard NN cord-024189-t7mbsr25 1128 13 . . . cord-024189-t7mbsr25 1129 1 The the DT cord-024189-t7mbsr25 1129 2 optimal optimal JJ cord-024189-t7mbsr25 1129 3 duration duration NN cord-024189-t7mbsr25 1129 4 of of IN cord-024189-t7mbsr25 1129 5 therapy therapy NN cord-024189-t7mbsr25 1129 6 is be VBZ cord-024189-t7mbsr25 1129 7 unknown unknown JJ cord-024189-t7mbsr25 1129 8 , , , cord-024189-t7mbsr25 1129 9 but but CC cord-024189-t7mbsr25 1129 10 in in IN cord-024189-t7mbsr25 1129 11 view view NN cord-024189-t7mbsr25 1129 12 of of IN cord-024189-t7mbsr25 1129 13 the the DT cord-024189-t7mbsr25 1129 14 substantial substantial JJ cord-024189-t7mbsr25 1129 15 side side NN cord-024189-t7mbsr25 1129 16 effects effect NNS cord-024189-t7mbsr25 1129 17 associated associate VBN cord-024189-t7mbsr25 1129 18 with with IN cord-024189-t7mbsr25 1129 19 cyclophosphamide cyclophosphamide NN cord-024189-t7mbsr25 1129 20 and and CC cord-024189-t7mbsr25 1129 21 the the DT cord-024189-t7mbsr25 1129 22 successful successful JJ cord-024189-t7mbsr25 1129 23 use use NN cord-024189-t7mbsr25 1129 24 of of IN cord-024189-t7mbsr25 1129 25 shorter short JJR cord-024189-t7mbsr25 1129 26 courses course NNS cord-024189-t7mbsr25 1129 27 of of IN cord-024189-t7mbsr25 1129 28 therapy therapy NN cord-024189-t7mbsr25 1129 29 in in IN cord-024189-t7mbsr25 1129 30 other other JJ cord-024189-t7mbsr25 1129 31 forms form NNS cord-024189-t7mbsr25 1129 32 of of IN cord-024189-t7mbsr25 1129 33 vasculitis vasculitis NN cord-024189-t7mbsr25 1129 34 , , , cord-024189-t7mbsr25 1129 35 a a DT cord-024189-t7mbsr25 1129 36 6-month 6-month CD cord-024189-t7mbsr25 1129 37 course course NN cord-024189-t7mbsr25 1129 38 of of IN cord-024189-t7mbsr25 1129 39 cyclophosphamide cyclophosphamide NN cord-024189-t7mbsr25 1129 40 followed follow VBN cord-024189-t7mbsr25 1129 41 by by IN cord-024189-t7mbsr25 1129 42 an an DT cord-024189-t7mbsr25 1129 43 additional additional JJ cord-024189-t7mbsr25 1129 44 1 1 CD cord-024189-t7mbsr25 1129 45 year year NN cord-024189-t7mbsr25 1129 46 of of IN cord-024189-t7mbsr25 1129 47 azathioprine azathioprine NNP cord-024189-t7mbsr25 1129 48 appears appear VBZ cord-024189-t7mbsr25 1129 49 reasonable reasonable JJ cord-024189-t7mbsr25 1129 50 . . . cord-024189-t7mbsr25 1130 1 Prednisone Prednisone NNP cord-024189-t7mbsr25 1130 2 should should MD cord-024189-t7mbsr25 1130 3 be be VB cord-024189-t7mbsr25 1130 4 discontinued discontinue VBN cord-024189-t7mbsr25 1130 5 in in IN cord-024189-t7mbsr25 1130 6 a a DT cord-024189-t7mbsr25 1130 7 tapering taper VBG cord-024189-t7mbsr25 1130 8 fashion fashion NN cord-024189-t7mbsr25 1130 9 over over IN cord-024189-t7mbsr25 1130 10 6 6 CD cord-024189-t7mbsr25 1130 11 to to TO cord-024189-t7mbsr25 1130 12 9 9 CD cord-024189-t7mbsr25 1130 13 months month NNS cord-024189-t7mbsr25 1130 14 . . . cord-024189-t7mbsr25 1131 1 The the DT cord-024189-t7mbsr25 1131 2 presence presence NN cord-024189-t7mbsr25 1131 3 of of IN cord-024189-t7mbsr25 1131 4 a a DT cord-024189-t7mbsr25 1131 5 subset subset NN cord-024189-t7mbsr25 1131 6 of of IN cord-024189-t7mbsr25 1131 7 patients patient NNS cord-024189-t7mbsr25 1131 8 with with IN cord-024189-t7mbsr25 1131 9 some some DT cord-024189-t7mbsr25 1131 10 features feature NNS cord-024189-t7mbsr25 1131 11 suggesting suggest VBG cord-024189-t7mbsr25 1131 12 PACNS PACNS NNP cord-024189-t7mbsr25 1131 13 but but CC cord-024189-t7mbsr25 1131 14 demonstrating demonstrate VBG cord-024189-t7mbsr25 1131 15 a a DT cord-024189-t7mbsr25 1131 16 more more RBR cord-024189-t7mbsr25 1131 17 benign benign JJ cord-024189-t7mbsr25 1131 18 course course NN cord-024189-t7mbsr25 1131 19 has have VBZ cord-024189-t7mbsr25 1131 20 been be VBN cord-024189-t7mbsr25 1131 21 suggested suggest VBN cord-024189-t7mbsr25 1131 22 ( ( -LRB- cord-024189-t7mbsr25 1131 23 19 19 CD cord-024189-t7mbsr25 1131 24 ) ) -RRB- cord-024189-t7mbsr25 1131 25 . . . cord-024189-t7mbsr25 1132 1 This this DT cord-024189-t7mbsr25 1132 2 subset subset NN cord-024189-t7mbsr25 1132 3 of of IN cord-024189-t7mbsr25 1132 4 patients patient NNS cord-024189-t7mbsr25 1132 5 is be VBZ cord-024189-t7mbsr25 1132 6 considered consider VBN cord-024189-t7mbsr25 1132 7 to to TO cord-024189-t7mbsr25 1132 8 have have VB cord-024189-t7mbsr25 1132 9 a a DT cord-024189-t7mbsr25 1132 10 disease disease NN cord-024189-t7mbsr25 1132 11 entity entity NN cord-024189-t7mbsr25 1132 12 known know VBN cord-024189-t7mbsr25 1132 13 as as IN cord-024189-t7mbsr25 1132 14 benign benign JJ cord-024189-t7mbsr25 1132 15 angiopathy angiopathy NNS cord-024189-t7mbsr25 1132 16 of of IN cord-024189-t7mbsr25 1132 17 the the DT cord-024189-t7mbsr25 1132 18 central central JJ cord-024189-t7mbsr25 1132 19 nervous nervous JJ cord-024189-t7mbsr25 1132 20 system system NN cord-024189-t7mbsr25 1132 21 ( ( -LRB- cord-024189-t7mbsr25 1132 22 BACNS BACNS NNP cord-024189-t7mbsr25 1132 23 ) ) -RRB- cord-024189-t7mbsr25 1132 24 . . . cord-024189-t7mbsr25 1133 1 BACNS bacns NN cord-024189-t7mbsr25 1133 2 patients patient NNS cord-024189-t7mbsr25 1133 3 are be VBP cord-024189-t7mbsr25 1133 4 predominantly predominantly RB cord-024189-t7mbsr25 1133 5 female female JJ cord-024189-t7mbsr25 1133 6 , , , cord-024189-t7mbsr25 1133 7 primarily primarily RB cord-024189-t7mbsr25 1133 8 present present VBP cord-024189-t7mbsr25 1133 9 acutely acutely RB cord-024189-t7mbsr25 1133 10 with with IN cord-024189-t7mbsr25 1133 11 headache headache NN cord-024189-t7mbsr25 1133 12 , , , cord-024189-t7mbsr25 1133 13 with with IN cord-024189-t7mbsr25 1133 14 or or CC cord-024189-t7mbsr25 1133 15 without without IN cord-024189-t7mbsr25 1133 16 focal focal JJ cord-024189-t7mbsr25 1133 17 symptoms symptom NNS cord-024189-t7mbsr25 1133 18 , , , cord-024189-t7mbsr25 1133 19 and and CC cord-024189-t7mbsr25 1133 20 have have VBP cord-024189-t7mbsr25 1133 21 normal normal JJ cord-024189-t7mbsr25 1133 22 or or CC cord-024189-t7mbsr25 1133 23 near near IN cord-024189-t7mbsr25 1133 24 normal normal JJ cord-024189-t7mbsr25 1133 25 CSF CSF NNP cord-024189-t7mbsr25 1133 26 analysis analysis NN cord-024189-t7mbsr25 1133 27 . . . cord-024189-t7mbsr25 1134 1 The the DT cord-024189-t7mbsr25 1134 2 diagnosis diagnosis NN cord-024189-t7mbsr25 1134 3 in in IN cord-024189-t7mbsr25 1134 4 these these DT cord-024189-t7mbsr25 1134 5 cases case NNS cord-024189-t7mbsr25 1134 6 has have VBZ cord-024189-t7mbsr25 1134 7 been be VBN cord-024189-t7mbsr25 1134 8 established establish VBN cord-024189-t7mbsr25 1134 9 angiographically angiographically RB cord-024189-t7mbsr25 1134 10 and and CC cord-024189-t7mbsr25 1134 11 appeared appear VBD cord-024189-t7mbsr25 1134 12 to to TO cord-024189-t7mbsr25 1134 13 have have VB cord-024189-t7mbsr25 1134 14 a a DT cord-024189-t7mbsr25 1134 15 monophasic monophasic JJ cord-024189-t7mbsr25 1134 16 course course NN cord-024189-t7mbsr25 1134 17 with with IN cord-024189-t7mbsr25 1134 18 a a DT cord-024189-t7mbsr25 1134 19 favorable favorable JJ cord-024189-t7mbsr25 1134 20 neurologic neurologic JJ cord-024189-t7mbsr25 1134 21 outcome outcome NN cord-024189-t7mbsr25 1134 22 . . . cord-024189-t7mbsr25 1135 1 Most Most JJS cord-024189-t7mbsr25 1135 2 of of IN cord-024189-t7mbsr25 1135 3 these these DT cord-024189-t7mbsr25 1135 4 patients patient NNS cord-024189-t7mbsr25 1135 5 recover recover VBP cord-024189-t7mbsr25 1135 6 after after IN cord-024189-t7mbsr25 1135 7 only only JJ cord-024189-t7mbsr25 1135 8 short short JJ cord-024189-t7mbsr25 1135 9 - - HYPH cord-024189-t7mbsr25 1135 10 term term NN cord-024189-t7mbsr25 1135 11 glucocorticoid glucocorticoid NN cord-024189-t7mbsr25 1135 12 treatment treatment NN cord-024189-t7mbsr25 1135 13 , , , cord-024189-t7mbsr25 1135 14 often often RB cord-024189-t7mbsr25 1135 15 supplemented supplement VBN cord-024189-t7mbsr25 1135 16 by by IN cord-024189-t7mbsr25 1135 17 a a DT cord-024189-t7mbsr25 1135 18 calcium calcium NN cord-024189-t7mbsr25 1135 19 channel channel NN cord-024189-t7mbsr25 1135 20 blocker blocker NN cord-024189-t7mbsr25 1135 21 to to TO cord-024189-t7mbsr25 1135 22 mitigate mitigate VB cord-024189-t7mbsr25 1135 23 against against IN cord-024189-t7mbsr25 1135 24 vasospasm vasospasm NN cord-024189-t7mbsr25 1135 25 . . . cord-024189-t7mbsr25 1136 1 Cytotoxic Cytotoxic NNP cord-024189-t7mbsr25 1136 2 agents agent NNS cord-024189-t7mbsr25 1136 3 are be VBP cord-024189-t7mbsr25 1136 4 not not RB cord-024189-t7mbsr25 1136 5 required require VBN cord-024189-t7mbsr25 1136 6 for for IN cord-024189-t7mbsr25 1136 7 patients patient NNS cord-024189-t7mbsr25 1136 8 with with IN cord-024189-t7mbsr25 1136 9 BACNS BACNS NNP cord-024189-t7mbsr25 1136 10 . . . cord-024189-t7mbsr25 1137 1 The the DT cord-024189-t7mbsr25 1137 2 etiology etiology NN cord-024189-t7mbsr25 1137 3 of of IN cord-024189-t7mbsr25 1137 4 the the DT cord-024189-t7mbsr25 1137 5 vascular vascular JJ cord-024189-t7mbsr25 1137 6 disease disease NN cord-024189-t7mbsr25 1137 7 in in IN cord-024189-t7mbsr25 1137 8 this this DT cord-024189-t7mbsr25 1137 9 benign benign JJ cord-024189-t7mbsr25 1137 10 form form NN cord-024189-t7mbsr25 1137 11 has have VBZ cord-024189-t7mbsr25 1137 12 not not RB cord-024189-t7mbsr25 1137 13 been be VBN cord-024189-t7mbsr25 1137 14 defi defi NNP cord-024189-t7mbsr25 1137 15 ned ned NNP cord-024189-t7mbsr25 1137 16 clearly clearly RB cord-024189-t7mbsr25 1137 17 , , , cord-024189-t7mbsr25 1137 18 but but CC cord-024189-t7mbsr25 1137 19 could could MD cord-024189-t7mbsr25 1137 20 be be VB cord-024189-t7mbsr25 1137 21 the the DT cord-024189-t7mbsr25 1137 22 result result NN cord-024189-t7mbsr25 1137 23 of of IN cord-024189-t7mbsr25 1137 24 arteritis arteritis NN cord-024189-t7mbsr25 1137 25 or or CC cord-024189-t7mbsr25 1137 26 reversible reversible JJ cord-024189-t7mbsr25 1137 27 vasospasm vasospasm NN cord-024189-t7mbsr25 1137 28 . . . cord-024189-t7mbsr25 1138 1 The the DT cord-024189-t7mbsr25 1138 2 existence existence NN cord-024189-t7mbsr25 1138 3 of of IN cord-024189-t7mbsr25 1138 4 a a DT cord-024189-t7mbsr25 1138 5 benign benign JJ cord-024189-t7mbsr25 1138 6 , , , cord-024189-t7mbsr25 1138 7 angiographically angiographically RB cord-024189-t7mbsr25 1138 8 defi defi NNP cord-024189-t7mbsr25 1138 9 ned ned NNP cord-024189-t7mbsr25 1138 10 subset subset NNP cord-024189-t7mbsr25 1138 11 , , , cord-024189-t7mbsr25 1138 12 however however RB cord-024189-t7mbsr25 1138 13 , , , cord-024189-t7mbsr25 1138 14 remains remain VBZ cord-024189-t7mbsr25 1138 15 controversial controversial JJ cord-024189-t7mbsr25 1138 16 ( ( -LRB- cord-024189-t7mbsr25 1138 17 20 20 CD cord-024189-t7mbsr25 1138 18 ) ) -RRB- cord-024189-t7mbsr25 1138 19 . . . cord-024189-t7mbsr25 1139 1 Recently recently RB cord-024189-t7mbsr25 1139 2 , , , cord-024189-t7mbsr25 1139 3 we -PRON- PRP cord-024189-t7mbsr25 1139 4 identifi identifi VBD cord-024189-t7mbsr25 1139 5 ed ed NNP cord-024189-t7mbsr25 1139 6 a a DT cord-024189-t7mbsr25 1139 7 subset subset NN cord-024189-t7mbsr25 1139 8 of of IN cord-024189-t7mbsr25 1139 9 patients patient NNS cord-024189-t7mbsr25 1139 10 presenting present VBG cord-024189-t7mbsr25 1139 11 with with IN cord-024189-t7mbsr25 1139 12 evidence evidence NN cord-024189-t7mbsr25 1139 13 of of IN cord-024189-t7mbsr25 1139 14 prominent prominent JJ cord-024189-t7mbsr25 1139 15 leptomeningeal leptomeningeal JJ cord-024189-t7mbsr25 1139 16 enhancement enhancement NN cord-024189-t7mbsr25 1139 17 on on IN cord-024189-t7mbsr25 1139 18 MRI MRI NNP cord-024189-t7mbsr25 1139 19 ( ( -LRB- cord-024189-t7mbsr25 1139 20 21 21 CD cord-024189-t7mbsr25 1139 21 ) ) -RRB- cord-024189-t7mbsr25 1139 22 . . . cord-024189-t7mbsr25 1140 1 These these DT cord-024189-t7mbsr25 1140 2 patients patient NNS cord-024189-t7mbsr25 1140 3 were be VBD cord-024189-t7mbsr25 1140 4 characterized characterize VBN cord-024189-t7mbsr25 1140 5 by by IN cord-024189-t7mbsr25 1140 6 normal normal JJ cord-024189-t7mbsr25 1140 7 cerebral cerebral JJ cord-024189-t7mbsr25 1140 8 angiography angiography NN cord-024189-t7mbsr25 1140 9 , , , cord-024189-t7mbsr25 1140 10 brain brain NN cord-024189-t7mbsr25 1140 11 biopsy biopsy NN cord-024189-t7mbsr25 1140 12 evidence evidence NN cord-024189-t7mbsr25 1140 13 of of IN cord-024189-t7mbsr25 1140 14 vasculitis vasculitis NN cord-024189-t7mbsr25 1140 15 predominantly predominantly RB cord-024189-t7mbsr25 1140 16 affecting affect VBG cord-024189-t7mbsr25 1140 17 the the DT cord-024189-t7mbsr25 1140 18 small small JJ cord-024189-t7mbsr25 1140 19 leptomeningeal leptomeningeal JJ cord-024189-t7mbsr25 1140 20 vessels vessel NNS cord-024189-t7mbsr25 1140 21 , , , cord-024189-t7mbsr25 1140 22 and and CC cord-024189-t7mbsr25 1140 23 a a DT cord-024189-t7mbsr25 1140 24 good good JJ cord-024189-t7mbsr25 1140 25 response response NN cord-024189-t7mbsr25 1140 26 to to IN cord-024189-t7mbsr25 1140 27 corticosteroids corticosteroid NNS cord-024189-t7mbsr25 1140 28 and/or and/or CC cord-024189-t7mbsr25 1140 29 immunosuppressive immunosuppressive JJ cord-024189-t7mbsr25 1140 30 therapy therapy NN cord-024189-t7mbsr25 1140 31 with with IN cord-024189-t7mbsr25 1140 32 a a DT cord-024189-t7mbsr25 1140 33 favorable favorable JJ cord-024189-t7mbsr25 1140 34 neurologic neurologic JJ cord-024189-t7mbsr25 1140 35 course course NN cord-024189-t7mbsr25 1140 36 . . . cord-024189-t7mbsr25 1141 1 Cogan Cogan NNP cord-024189-t7mbsr25 1141 2 's 's POS cord-024189-t7mbsr25 1141 3 syndrome syndrome NN cord-024189-t7mbsr25 1141 4 refers refer VBZ cord-024189-t7mbsr25 1141 5 to to IN cord-024189-t7mbsr25 1141 6 the the DT cord-024189-t7mbsr25 1141 7 association association NNP cord-024189-t7mbsr25 1141 8 of of IN cord-024189-t7mbsr25 1141 9 nonsyphilitic nonsyphilitic NNP cord-024189-t7mbsr25 1141 10 interstitial interstitial JJ cord-024189-t7mbsr25 1141 11 keratitis keratitis NNP cord-024189-t7mbsr25 1141 12 ( ( -LRB- cord-024189-t7mbsr25 1141 13 Figure figure NN cord-024189-t7mbsr25 1141 14 21E-6 21e-6 CD cord-024189-t7mbsr25 1141 15 ) ) -RRB- cord-024189-t7mbsr25 1141 16 and and CC cord-024189-t7mbsr25 1141 17 immunemediated immunemediated JJ cord-024189-t7mbsr25 1141 18 inner inner JJ cord-024189-t7mbsr25 1141 19 ear ear NN cord-024189-t7mbsr25 1141 20 disease disease NN cord-024189-t7mbsr25 1141 21 , , , cord-024189-t7mbsr25 1141 22 resulting result VBG cord-024189-t7mbsr25 1141 23 in in IN cord-024189-t7mbsr25 1141 24 audiovestibular audiovestibular NNP cord-024189-t7mbsr25 1141 25 dysfunction dysfunction NN cord-024189-t7mbsr25 1141 26 . . . cord-024189-t7mbsr25 1142 1 The the DT cord-024189-t7mbsr25 1142 2 disorder disorder NN cord-024189-t7mbsr25 1142 3 affects affect VBZ cord-024189-t7mbsr25 1142 4 men man NNS cord-024189-t7mbsr25 1142 5 and and CC cord-024189-t7mbsr25 1142 6 women woman NNS cord-024189-t7mbsr25 1142 7 equally equally RB cord-024189-t7mbsr25 1142 8 at at IN cord-024189-t7mbsr25 1142 9 any any DT cord-024189-t7mbsr25 1142 10 age age NN cord-024189-t7mbsr25 1142 11 , , , cord-024189-t7mbsr25 1142 12 but but CC cord-024189-t7mbsr25 1142 13 typically typically RB cord-024189-t7mbsr25 1142 14 in in IN cord-024189-t7mbsr25 1142 15 their -PRON- PRP$ cord-024189-t7mbsr25 1142 16 third third JJ cord-024189-t7mbsr25 1142 17 and and CC cord-024189-t7mbsr25 1142 18 fourth fourth JJ cord-024189-t7mbsr25 1142 19 decade decade NN cord-024189-t7mbsr25 1142 20 . . . cord-024189-t7mbsr25 1143 1 Presenting present VBG cord-024189-t7mbsr25 1143 2 manifestations manifestation NNS cord-024189-t7mbsr25 1143 3 include include VBP cord-024189-t7mbsr25 1143 4 sudden sudden JJ cord-024189-t7mbsr25 1143 5 hearing hearing NN cord-024189-t7mbsr25 1143 6 loss loss NN cord-024189-t7mbsr25 1143 7 , , , cord-024189-t7mbsr25 1143 8 Ménière's Ménière's NNP cord-024189-t7mbsr25 1143 9 - - HYPH cord-024189-t7mbsr25 1143 10 like like JJ cord-024189-t7mbsr25 1143 11 vertigo vertigo NN cord-024189-t7mbsr25 1143 12 and and CC cord-024189-t7mbsr25 1143 13 tinnitus tinnitus NN cord-024189-t7mbsr25 1143 14 , , , cord-024189-t7mbsr25 1143 15 and and CC cord-024189-t7mbsr25 1143 16 ocular ocular JJ cord-024189-t7mbsr25 1143 17 infl infl NN cord-024189-t7mbsr25 1143 18 ammation ammation NN cord-024189-t7mbsr25 1143 19 , , , cord-024189-t7mbsr25 1143 20 alone alone RB cord-024189-t7mbsr25 1143 21 or or CC cord-024189-t7mbsr25 1143 22 in in IN cord-024189-t7mbsr25 1143 23 any any DT cord-024189-t7mbsr25 1143 24 combination combination NN cord-024189-t7mbsr25 1143 25 ( ( -LRB- cord-024189-t7mbsr25 1143 26 22 22 CD cord-024189-t7mbsr25 1143 27 ) ) -RRB- cord-024189-t7mbsr25 1143 28 . . . cord-024189-t7mbsr25 1144 1 Other other JJ cord-024189-t7mbsr25 1144 2 features feature NNS cord-024189-t7mbsr25 1144 3 of of IN cord-024189-t7mbsr25 1144 4 the the DT cord-024189-t7mbsr25 1144 5 disease disease NN cord-024189-t7mbsr25 1144 6 , , , cord-024189-t7mbsr25 1144 7 if if IN cord-024189-t7mbsr25 1144 8 not not RB cord-024189-t7mbsr25 1144 9 present present JJ cord-024189-t7mbsr25 1144 10 initially initially RB cord-024189-t7mbsr25 1144 11 , , , cord-024189-t7mbsr25 1144 12 usually usually RB cord-024189-t7mbsr25 1144 13 follow follow VBP cord-024189-t7mbsr25 1144 14 within within IN cord-024189-t7mbsr25 1144 15 several several JJ cord-024189-t7mbsr25 1144 16 months month NNS cord-024189-t7mbsr25 1144 17 . . . cord-024189-t7mbsr25 1145 1 Hearing hear VBG cord-024189-t7mbsr25 1145 2 loss loss NN cord-024189-t7mbsr25 1145 3 is be VBZ cord-024189-t7mbsr25 1145 4 bilateral bilateral JJ cord-024189-t7mbsr25 1145 5 , , , cord-024189-t7mbsr25 1145 6 shows show VBZ cord-024189-t7mbsr25 1145 7 a a DT cord-024189-t7mbsr25 1145 8 downsloping downsloping NN cord-024189-t7mbsr25 1145 9 pattern pattern NN cord-024189-t7mbsr25 1145 10 on on IN cord-024189-t7mbsr25 1145 11 audiograms audiograms NNP cord-024189-t7mbsr25 1145 12 , , , cord-024189-t7mbsr25 1145 13 and and CC cord-024189-t7mbsr25 1145 14 is be VBZ cord-024189-t7mbsr25 1145 15 often often RB cord-024189-t7mbsr25 1145 16 progressive progressive JJ cord-024189-t7mbsr25 1145 17 and and CC cord-024189-t7mbsr25 1145 18 profound profound JJ cord-024189-t7mbsr25 1145 19 . . . cord-024189-t7mbsr25 1146 1 Vestibular vestibular JJ cord-024189-t7mbsr25 1146 2 testing testing NN cord-024189-t7mbsr25 1146 3 shows show VBZ cord-024189-t7mbsr25 1146 4 bilateral bilateral JJ cord-024189-t7mbsr25 1146 5 cochlear cochlear JJ cord-024189-t7mbsr25 1146 6 dysfunction dysfunction NN cord-024189-t7mbsr25 1146 7 , , , cord-024189-t7mbsr25 1146 8 helping help VBG cord-024189-t7mbsr25 1146 9 to to TO cord-024189-t7mbsr25 1146 10 distinguish distinguish VB cord-024189-t7mbsr25 1146 11 this this DT cord-024189-t7mbsr25 1146 12 disorder disorder NN cord-024189-t7mbsr25 1146 13 from from IN cord-024189-t7mbsr25 1146 14 Ménière Ménière NNP cord-024189-t7mbsr25 1146 15 's 's POS cord-024189-t7mbsr25 1146 16 syndrome syndrome NN cord-024189-t7mbsr25 1146 17 . . . cord-024189-t7mbsr25 1147 1 In in IN cord-024189-t7mbsr25 1147 2 comparison comparison NN cord-024189-t7mbsr25 1147 3 to to IN cord-024189-t7mbsr25 1147 4 Ménière Ménière NNP cord-024189-t7mbsr25 1147 5 's 's POS cord-024189-t7mbsr25 1147 6 syndrome syndrome NN cord-024189-t7mbsr25 1147 7 , , , cord-024189-t7mbsr25 1147 8 the the DT cord-024189-t7mbsr25 1147 9 damage damage NN cord-024189-t7mbsr25 1147 10 to to IN cord-024189-t7mbsr25 1147 11 hearing hear VBG cord-024189-t7mbsr25 1147 12 from from IN cord-024189-t7mbsr25 1147 13 Cogan Cogan NNP cord-024189-t7mbsr25 1147 14 's 's POS cord-024189-t7mbsr25 1147 15 syndrome syndrome NN cord-024189-t7mbsr25 1147 16 is be VBZ cord-024189-t7mbsr25 1147 17 typically typically RB cord-024189-t7mbsr25 1147 18 more more RBR cord-024189-t7mbsr25 1147 19 unremitting unremitting JJ cord-024189-t7mbsr25 1147 20 . . . cord-024189-t7mbsr25 1148 1 Scleritis Scleritis NNP cord-024189-t7mbsr25 1148 2 , , , cord-024189-t7mbsr25 1148 3 uveitis uveitis NN cord-024189-t7mbsr25 1148 4 , , , cord-024189-t7mbsr25 1148 5 or or CC cord-024189-t7mbsr25 1148 6 other other JJ cord-024189-t7mbsr25 1148 7 infl infl NN cord-024189-t7mbsr25 1148 8 ammatory ammatory NN cord-024189-t7mbsr25 1148 9 conditions condition NNS cord-024189-t7mbsr25 1148 10 of of IN cord-024189-t7mbsr25 1148 11 the the DT cord-024189-t7mbsr25 1148 12 eye eye NN cord-024189-t7mbsr25 1148 13 ( ( -LRB- cord-024189-t7mbsr25 1148 14 Figure figure NN cord-024189-t7mbsr25 1148 15 21E 21e CD cord-024189-t7mbsr25 1148 16 -7 -7 CD cord-024189-t7mbsr25 1148 17 ) ) -RRB- cord-024189-t7mbsr25 1148 18 may may MD cord-024189-t7mbsr25 1148 19 be be VB cord-024189-t7mbsr25 1148 20 present present JJ cord-024189-t7mbsr25 1148 21 initially initially RB cord-024189-t7mbsr25 1148 22 but but CC cord-024189-t7mbsr25 1148 23 often often RB cord-024189-t7mbsr25 1148 24 patients patient NNS cord-024189-t7mbsr25 1148 25 will will MD cord-024189-t7mbsr25 1148 26 subsequently subsequently RB cord-024189-t7mbsr25 1148 27 develop develop VB cord-024189-t7mbsr25 1148 28 interstitial interstitial JJ cord-024189-t7mbsr25 1148 29 keratitis keratitis NN cord-024189-t7mbsr25 1148 30 if if IN cord-024189-t7mbsr25 1148 31 not not RB cord-024189-t7mbsr25 1148 32 present present JJ cord-024189-t7mbsr25 1148 33 initially initially RB cord-024189-t7mbsr25 1148 34 . . . cord-024189-t7mbsr25 1149 1 Systemic systemic JJ cord-024189-t7mbsr25 1149 2 manifestations manifestation NNS cord-024189-t7mbsr25 1149 3 include include VBP cord-024189-t7mbsr25 1149 4 headache headache NN cord-024189-t7mbsr25 1149 5 , , , cord-024189-t7mbsr25 1149 6 fever fever NN cord-024189-t7mbsr25 1149 7 , , , cord-024189-t7mbsr25 1149 8 arthralgia arthralgia NN cord-024189-t7mbsr25 1149 9 , , , cord-024189-t7mbsr25 1149 10 and and CC cord-024189-t7mbsr25 1149 11 vasculitis vasculitis NN cord-024189-t7mbsr25 1149 12 , , , cord-024189-t7mbsr25 1149 13 with with IN cord-024189-t7mbsr25 1149 14 or or CC cord-024189-t7mbsr25 1149 15 without without IN cord-024189-t7mbsr25 1149 16 aortitis aortitis NNP cord-024189-t7mbsr25 1149 17 . . . cord-024189-t7mbsr25 1150 1 The the DT cord-024189-t7mbsr25 1150 2 critical critical JJ cord-024189-t7mbsr25 1150 3 evaluation evaluation NN cord-024189-t7mbsr25 1150 4 and and CC cord-024189-t7mbsr25 1150 5 monitoring monitoring NN cord-024189-t7mbsr25 1150 6 of of IN cord-024189-t7mbsr25 1150 7 Cogan Cogan NNP cord-024189-t7mbsr25 1150 8 's 's POS cord-024189-t7mbsr25 1150 9 patients patient NNS cord-024189-t7mbsr25 1150 10 requires require VBZ cord-024189-t7mbsr25 1150 11 the the DT cord-024189-t7mbsr25 1150 12 expertise expertise NN cord-024189-t7mbsr25 1150 13 and and CC cord-024189-t7mbsr25 1150 14 collaboration collaboration NN cord-024189-t7mbsr25 1150 15 of of IN cord-024189-t7mbsr25 1150 16 the the DT cord-024189-t7mbsr25 1150 17 treating treat VBG cord-024189-t7mbsr25 1150 18 rheumatologist rheumatologist NN cord-024189-t7mbsr25 1150 19 , , , cord-024189-t7mbsr25 1150 20 otolaryngologist otolaryngologist NN cord-024189-t7mbsr25 1150 21 , , , cord-024189-t7mbsr25 1150 22 and and CC cord-024189-t7mbsr25 1150 23 ophthalmologist ophthalmologist NN cord-024189-t7mbsr25 1150 24 ( ( -LRB- cord-024189-t7mbsr25 1150 25 23 23 CD cord-024189-t7mbsr25 1150 26 ) ) -RRB- cord-024189-t7mbsr25 1150 27 . . . cord-024189-t7mbsr25 1151 1 There there EX cord-024189-t7mbsr25 1151 2 are be VBP cord-024189-t7mbsr25 1151 3 no no DT cord-024189-t7mbsr25 1151 4 controlled control VBN cord-024189-t7mbsr25 1151 5 studies study NNS cord-024189-t7mbsr25 1151 6 on on IN cord-024189-t7mbsr25 1151 7 the the DT cord-024189-t7mbsr25 1151 8 treatment treatment NN cord-024189-t7mbsr25 1151 9 of of IN cord-024189-t7mbsr25 1151 10 Cogan Cogan NNP cord-024189-t7mbsr25 1151 11 's 's POS cord-024189-t7mbsr25 1151 12 syndrome syndrome NN cord-024189-t7mbsr25 1151 13 . . . cord-024189-t7mbsr25 1152 1 Glucocorticoids Glucocorticoids NNP cord-024189-t7mbsr25 1152 2 are be VBP cord-024189-t7mbsr25 1152 3 used use VBN cord-024189-t7mbsr25 1152 4 topically topically RB cord-024189-t7mbsr25 1152 5 for for IN cord-024189-t7mbsr25 1152 6 anterior anterior JJ cord-024189-t7mbsr25 1152 7 eye eye NN cord-024189-t7mbsr25 1152 8 disease disease NN cord-024189-t7mbsr25 1152 9 and and CC cord-024189-t7mbsr25 1152 10 systemically systemically RB cord-024189-t7mbsr25 1152 11 for for IN cord-024189-t7mbsr25 1152 12 audiovestibular audiovestibular NNP cord-024189-t7mbsr25 1152 13 manifestations manifestation NNS cord-024189-t7mbsr25 1152 14 , , , cord-024189-t7mbsr25 1152 15 unremitting unremitting JJ cord-024189-t7mbsr25 1152 16 ocular ocular JJ cord-024189-t7mbsr25 1152 17 disease disease NN cord-024189-t7mbsr25 1152 18 , , , cord-024189-t7mbsr25 1152 19 or or CC cord-024189-t7mbsr25 1152 20 when when WRB cord-024189-t7mbsr25 1152 21 the the DT cord-024189-t7mbsr25 1152 22 disorder disorder NN cord-024189-t7mbsr25 1152 23 is be VBZ cord-024189-t7mbsr25 1152 24 complicated complicate VBN cord-024189-t7mbsr25 1152 25 by by IN cord-024189-t7mbsr25 1152 26 vasculitis vasculitis NN cord-024189-t7mbsr25 1152 27 or or CC cord-024189-t7mbsr25 1152 28 significant significant JJ cord-024189-t7mbsr25 1152 29 systemic systemic JJ cord-024189-t7mbsr25 1152 30 manifestations manifestation NNS cord-024189-t7mbsr25 1152 31 . . . cord-024189-t7mbsr25 1153 1 These these DT cord-024189-t7mbsr25 1153 2 agents agent NNS cord-024189-t7mbsr25 1153 3 should should MD cord-024189-t7mbsr25 1153 4 be be VB cord-024189-t7mbsr25 1153 5 started start VBN cord-024189-t7mbsr25 1153 6 as as RB cord-024189-t7mbsr25 1153 7 soon soon RB cord-024189-t7mbsr25 1153 8 as as IN cord-024189-t7mbsr25 1153 9 the the DT cord-024189-t7mbsr25 1153 10 disorder disorder NN cord-024189-t7mbsr25 1153 11 is be VBZ cord-024189-t7mbsr25 1153 12 recognized recognize VBN cord-024189-t7mbsr25 1153 13 , , , cord-024189-t7mbsr25 1153 14 in in IN cord-024189-t7mbsr25 1153 15 adequate adequate JJ cord-024189-t7mbsr25 1153 16 doses dose NNS cord-024189-t7mbsr25 1153 17 ( ( -LRB- cord-024189-t7mbsr25 1153 18 at at RB cord-024189-t7mbsr25 1153 19 least least JJS cord-024189-t7mbsr25 1153 20 1 1 CD cord-024189-t7mbsr25 1153 21 mg mg NNP cord-024189-t7mbsr25 1153 22 / / SYM cord-024189-t7mbsr25 1153 23 kg kg NNP cord-024189-t7mbsr25 1153 24 / / SYM cord-024189-t7mbsr25 1153 25 day day NN cord-024189-t7mbsr25 1153 26 ) ) -RRB- cord-024189-t7mbsr25 1153 27 , , , cord-024189-t7mbsr25 1153 28 and and CC cord-024189-t7mbsr25 1153 29 for for IN cord-024189-t7mbsr25 1153 30 a a DT cord-024189-t7mbsr25 1153 31 suffi suffi NNP cord-024189-t7mbsr25 1153 32 cient cient JJ cord-024189-t7mbsr25 1153 33 duration duration NN cord-024189-t7mbsr25 1153 34 to to TO cord-024189-t7mbsr25 1153 35 initially initially RB cord-024189-t7mbsr25 1153 36 control control VB cord-024189-t7mbsr25 1153 37 the the DT cord-024189-t7mbsr25 1153 38 disease disease NN cord-024189-t7mbsr25 1153 39 or or CC cord-024189-t7mbsr25 1153 40 for for IN cord-024189-t7mbsr25 1153 41 relapse relapse NN cord-024189-t7mbsr25 1153 42 . . . cord-024189-t7mbsr25 1154 1 Documented document VBN cord-024189-t7mbsr25 1154 2 improvement improvement NN cord-024189-t7mbsr25 1154 3 in in IN cord-024189-t7mbsr25 1154 4 2 2 CD cord-024189-t7mbsr25 1154 5 to to TO cord-024189-t7mbsr25 1154 6 3 3 CD cord-024189-t7mbsr25 1154 7 weeks week NNS cord-024189-t7mbsr25 1154 8 supports support VBZ cord-024189-t7mbsr25 1154 9 a a DT cord-024189-t7mbsr25 1154 10 therapeutic therapeutic JJ cord-024189-t7mbsr25 1154 11 response response NN cord-024189-t7mbsr25 1154 12 and and CC cord-024189-t7mbsr25 1154 13 can can MD cord-024189-t7mbsr25 1154 14 be be VB cord-024189-t7mbsr25 1154 15 followed follow VBN cord-024189-t7mbsr25 1154 16 by by IN cord-024189-t7mbsr25 1154 17 gradual gradual JJ cord-024189-t7mbsr25 1154 18 tapering tapering NN cord-024189-t7mbsr25 1154 19 of of IN cord-024189-t7mbsr25 1154 20 the the DT cord-024189-t7mbsr25 1154 21 dose dose NN cord-024189-t7mbsr25 1154 22 and and CC cord-024189-t7mbsr25 1154 23 use use NN cord-024189-t7mbsr25 1154 24 of of IN cord-024189-t7mbsr25 1154 25 immunosuppressive immunosuppressive JJ cord-024189-t7mbsr25 1154 26 agents agent NNS cord-024189-t7mbsr25 1154 27 if if IN cord-024189-t7mbsr25 1154 28 necessary necessary JJ cord-024189-t7mbsr25 1154 29 for for IN cord-024189-t7mbsr25 1154 30 maintenance maintenance NN cord-024189-t7mbsr25 1154 31 . . . cord-024189-t7mbsr25 1155 1 The the DT cord-024189-t7mbsr25 1155 2 prognosis prognosis NN cord-024189-t7mbsr25 1155 3 for for IN cord-024189-t7mbsr25 1155 4 hearing hearing NN cord-024189-t7mbsr25 1155 5 in in IN cord-024189-t7mbsr25 1155 6 these these DT cord-024189-t7mbsr25 1155 7 patients patient NNS cord-024189-t7mbsr25 1155 8 has have VBZ cord-024189-t7mbsr25 1155 9 been be VBN cord-024189-t7mbsr25 1155 10 poor poor JJ cord-024189-t7mbsr25 1155 11 ( ( -LRB- cord-024189-t7mbsr25 1155 12 22 22 CD cord-024189-t7mbsr25 1155 13 ) ) -RRB- cord-024189-t7mbsr25 1155 14 , , , cord-024189-t7mbsr25 1155 15 but but CC cord-024189-t7mbsr25 1155 16 cochlear cochlear JJ cord-024189-t7mbsr25 1155 17 implants implant NNS cord-024189-t7mbsr25 1155 18 are be VBP cord-024189-t7mbsr25 1155 19 used use VBN cord-024189-t7mbsr25 1155 20 successfully successfully RB cord-024189-t7mbsr25 1155 21 in in IN cord-024189-t7mbsr25 1155 22 these these DT cord-024189-t7mbsr25 1155 23 patients patient NNS cord-024189-t7mbsr25 1155 24 with with IN cord-024189-t7mbsr25 1155 25 bilateral bilateral JJ cord-024189-t7mbsr25 1155 26 deafness deafness NN cord-024189-t7mbsr25 1155 27 . . . cord-024189-t7mbsr25 1156 1 Erythema Erythema NNP cord-024189-t7mbsr25 1156 2 elevatum elevatum NNP cord-024189-t7mbsr25 1156 3 diutinum diutinum NN cord-024189-t7mbsr25 1156 4 ( ( -LRB- cord-024189-t7mbsr25 1156 5 EED EED NNP cord-024189-t7mbsr25 1156 6 ) ) -RRB- cord-024189-t7mbsr25 1156 7 is be VBZ cord-024189-t7mbsr25 1156 8 an an DT cord-024189-t7mbsr25 1156 9 extremely extremely RB cord-024189-t7mbsr25 1156 10 rare rare JJ cord-024189-t7mbsr25 1156 11 , , , cord-024189-t7mbsr25 1156 12 chronic chronic JJ cord-024189-t7mbsr25 1156 13 , , , cord-024189-t7mbsr25 1156 14 recurrent recurrent JJ cord-024189-t7mbsr25 1156 15 vasculitis vasculitis NN cord-024189-t7mbsr25 1156 16 with with IN cord-024189-t7mbsr25 1156 17 distinctive distinctive JJ cord-024189-t7mbsr25 1156 18 clinical clinical JJ cord-024189-t7mbsr25 1156 19 and and CC cord-024189-t7mbsr25 1156 20 histopathologic histopathologic JJ cord-024189-t7mbsr25 1156 21 features feature NNS cord-024189-t7mbsr25 1156 22 ( ( -LRB- cord-024189-t7mbsr25 1156 23 24,25 24,25 CD cord-024189-t7mbsr25 1156 24 ) ) -RRB- cord-024189-t7mbsr25 1156 25 . . . cord-024189-t7mbsr25 1157 1 The the DT cord-024189-t7mbsr25 1157 2 disorder disorder NN cord-024189-t7mbsr25 1157 3 affects affect VBZ cord-024189-t7mbsr25 1157 4 both both DT cord-024189-t7mbsr25 1157 5 men man NNS cord-024189-t7mbsr25 1157 6 and and CC cord-024189-t7mbsr25 1157 7 women woman NNS cord-024189-t7mbsr25 1157 8 in in IN cord-024189-t7mbsr25 1157 9 middle middle JJ cord-024189-t7mbsr25 1157 10 age age NN cord-024189-t7mbsr25 1157 11 . . . cord-024189-t7mbsr25 1158 1 Individual individual JJ cord-024189-t7mbsr25 1158 2 lesions lesion NNS cord-024189-t7mbsr25 1158 3 consist consist VBP cord-024189-t7mbsr25 1158 4 of of IN cord-024189-t7mbsr25 1158 5 purple purple JJ cord-024189-t7mbsr25 1158 6 , , , cord-024189-t7mbsr25 1158 7 red red JJ cord-024189-t7mbsr25 1158 8 , , , cord-024189-t7mbsr25 1158 9 or or CC cord-024189-t7mbsr25 1158 10 brown brown JJ cord-024189-t7mbsr25 1158 11 plaques plaque NNS cord-024189-t7mbsr25 1158 12 that that WDT cord-024189-t7mbsr25 1158 13 often often RB cord-024189-t7mbsr25 1158 14 have have VBP cord-024189-t7mbsr25 1158 15 an an DT cord-024189-t7mbsr25 1158 16 annular annular JJ cord-024189-t7mbsr25 1158 17 or or CC cord-024189-t7mbsr25 1158 18 nodular nodular JJ cord-024189-t7mbsr25 1158 19 appearance appearance NN cord-024189-t7mbsr25 1158 20 . . . cord-024189-t7mbsr25 1159 1 The the DT cord-024189-t7mbsr25 1159 2 skin skin NN cord-024189-t7mbsr25 1159 3 lesions lesion NNS cord-024189-t7mbsr25 1159 4 of of IN cord-024189-t7mbsr25 1159 5 EED EED NNP cord-024189-t7mbsr25 1159 6 have have VBP cord-024189-t7mbsr25 1159 7 a a DT cord-024189-t7mbsr25 1159 8 predilection predilection NN cord-024189-t7mbsr25 1159 9 for for IN cord-024189-t7mbsr25 1159 10 the the DT cord-024189-t7mbsr25 1159 11 extensor extensor JJ cord-024189-t7mbsr25 1159 12 surfaces surface NNS cord-024189-t7mbsr25 1159 13 of of IN cord-024189-t7mbsr25 1159 14 the the DT cord-024189-t7mbsr25 1159 15 distal distal JJ cord-024189-t7mbsr25 1159 16 extremities extremity NNS cord-024189-t7mbsr25 1159 17 and and CC cord-024189-t7mbsr25 1159 18 often often RB cord-024189-t7mbsr25 1159 19 overlie overlie VBP cord-024189-t7mbsr25 1159 20 joints joint NNS cord-024189-t7mbsr25 1159 21 , , , cord-024189-t7mbsr25 1159 22 but but CC cord-024189-t7mbsr25 1159 23 may may MD cord-024189-t7mbsr25 1159 24 be be VB cord-024189-t7mbsr25 1159 25 generalized generalize VBN cord-024189-t7mbsr25 1159 26 . . . cord-024189-t7mbsr25 1160 1 Older old JJR cord-024189-t7mbsr25 1160 2 lesions lesion NNS cord-024189-t7mbsr25 1160 3 may may MD cord-024189-t7mbsr25 1160 4 be be VB cord-024189-t7mbsr25 1160 5 dense dense JJ cord-024189-t7mbsr25 1160 6 and and CC cord-024189-t7mbsr25 1160 7 coalesce coalesce VB cord-024189-t7mbsr25 1160 8 ( ( -LRB- cord-024189-t7mbsr25 1160 9 Figure figure NN cord-024189-t7mbsr25 1160 10 21E-8 21e-8 CD cord-024189-t7mbsr25 1160 11 ) ) -RRB- cord-024189-t7mbsr25 1160 12 . . . cord-024189-t7mbsr25 1161 1 Erupting erupt VBG cord-024189-t7mbsr25 1161 2 lesions lesion NNS cord-024189-t7mbsr25 1161 3 may may MD cord-024189-t7mbsr25 1161 4 be be VB cord-024189-t7mbsr25 1161 5 associated associate VBN cord-024189-t7mbsr25 1161 6 with with IN cord-024189-t7mbsr25 1161 7 stinging stinging JJ cord-024189-t7mbsr25 1161 8 , , , cord-024189-t7mbsr25 1161 9 burning burning NN cord-024189-t7mbsr25 1161 10 , , , cord-024189-t7mbsr25 1161 11 or or CC cord-024189-t7mbsr25 1161 12 tenderness tenderness NN cord-024189-t7mbsr25 1161 13 , , , cord-024189-t7mbsr25 1161 14 and and CC cord-024189-t7mbsr25 1161 15 may may MD cord-024189-t7mbsr25 1161 16 be be VB cord-024189-t7mbsr25 1161 17 accompanied accompany VBN cord-024189-t7mbsr25 1161 18 by by IN cord-024189-t7mbsr25 1161 19 systemic systemic JJ cord-024189-t7mbsr25 1161 20 symptoms symptom NNS cord-024189-t7mbsr25 1161 21 . . . cord-024189-t7mbsr25 1162 1 In in IN cord-024189-t7mbsr25 1162 2 early early JJ cord-024189-t7mbsr25 1162 3 lesions lesion NNS cord-024189-t7mbsr25 1162 4 , , , cord-024189-t7mbsr25 1162 5 the the DT cord-024189-t7mbsr25 1162 6 pathology pathology NN cord-024189-t7mbsr25 1162 7 of of IN cord-024189-t7mbsr25 1162 8 EED EED NNP cord-024189-t7mbsr25 1162 9 is be VBZ cord-024189-t7mbsr25 1162 10 one one CD cord-024189-t7mbsr25 1162 11 of of IN cord-024189-t7mbsr25 1162 12 a a DT cord-024189-t7mbsr25 1162 13 leukocytoclastic leukocytoclastic JJ cord-024189-t7mbsr25 1162 14 vasculitis vasculitis NN cord-024189-t7mbsr25 1162 15 with with IN cord-024189-t7mbsr25 1162 16 a a DT cord-024189-t7mbsr25 1162 17 perivascular perivascular NNP cord-024189-t7mbsr25 1162 18 neutrophilic neutrophilic NNP cord-024189-t7mbsr25 1162 19 infi infi NNP cord-024189-t7mbsr25 1162 20 ltrate ltrate NNP cord-024189-t7mbsr25 1162 21 . . . cord-024189-t7mbsr25 1163 1 More More JJR cord-024189-t7mbsr25 1163 2 mature mature JJ cord-024189-t7mbsr25 1163 3 lesions lesion NNS cord-024189-t7mbsr25 1163 4 demonstrate demonstrate VBP cord-024189-t7mbsr25 1163 5 perivascular perivascular JJ cord-024189-t7mbsr25 1163 6 or or CC cord-024189-t7mbsr25 1163 7 onion onion NN cord-024189-t7mbsr25 1163 8 - - HYPH cord-024189-t7mbsr25 1163 9 skinlike skinlike JJ cord-024189-t7mbsr25 1163 10 fi fi NN cord-024189-t7mbsr25 1163 11 brosis brosis NN cord-024189-t7mbsr25 1163 12 . . . cord-024189-t7mbsr25 1164 1 Capillary capillary JJ cord-024189-t7mbsr25 1164 2 proliferation proliferation NN cord-024189-t7mbsr25 1164 3 and and CC cord-024189-t7mbsr25 1164 4 cholesterolcontaining cholesterolcontaine VBG cord-024189-t7mbsr25 1164 5 histiocytes histiocyte NNS cord-024189-t7mbsr25 1164 6 may may MD cord-024189-t7mbsr25 1164 7 also also RB cord-024189-t7mbsr25 1164 8 be be VB cord-024189-t7mbsr25 1164 9 seen see VBN cord-024189-t7mbsr25 1164 10 . . . cord-024189-t7mbsr25 1165 1 The the DT cord-024189-t7mbsr25 1165 2 differential differential JJ cord-024189-t7mbsr25 1165 3 diagnosis diagnosis NN cord-024189-t7mbsr25 1165 4 includes include VBZ cord-024189-t7mbsr25 1165 5 other other JJ cord-024189-t7mbsr25 1165 6 neutrophilic neutrophilic NNP cord-024189-t7mbsr25 1165 7 dermatoses dermatosis NNS cord-024189-t7mbsr25 1165 8 , , , cord-024189-t7mbsr25 1165 9 primarily primarily RB cord-024189-t7mbsr25 1165 10 Sweet Sweet NNP cord-024189-t7mbsr25 1165 11 's 's POS cord-024189-t7mbsr25 1165 12 syndrome syndrome NN cord-024189-t7mbsr25 1165 13 . . . cord-024189-t7mbsr25 1166 1 Erythema Erythema NNP cord-024189-t7mbsr25 1166 2 elevatum elevatum NNP cord-024189-t7mbsr25 1166 3 diutinum diutinum NNP cord-024189-t7mbsr25 1166 4 has have VBZ cord-024189-t7mbsr25 1166 5 been be VBN cord-024189-t7mbsr25 1166 6 recognized recognize VBN cord-024189-t7mbsr25 1166 7 to to TO cord-024189-t7mbsr25 1166 8 occur occur VB cord-024189-t7mbsr25 1166 9 in in IN cord-024189-t7mbsr25 1166 10 association association NN cord-024189-t7mbsr25 1166 11 with with IN cord-024189-t7mbsr25 1166 12 infections infection NNS cord-024189-t7mbsr25 1166 13 diseases disease NNS cord-024189-t7mbsr25 1166 14 , , , cord-024189-t7mbsr25 1166 15 including include VBG cord-024189-t7mbsr25 1166 16 human human JJ cord-024189-t7mbsr25 1166 17 immunodecifi immunodecifi NNP cord-024189-t7mbsr25 1166 18 ency ency NNP cord-024189-t7mbsr25 1166 19 virus virus NN cord-024189-t7mbsr25 1166 20 infection infection NN cord-024189-t7mbsr25 1166 21 , , , cord-024189-t7mbsr25 1166 22 hematologic hematologic JJ cord-024189-t7mbsr25 1166 23 disorders disorder NNS cord-024189-t7mbsr25 1166 24 ( ( -LRB- cord-024189-t7mbsr25 1166 25 particularly particularly RB cord-024189-t7mbsr25 1166 26 IgA IgA NNP cord-024189-t7mbsr25 1166 27 gammopathies gammopathies NNP cord-024189-t7mbsr25 1166 28 ) ) -RRB- cord-024189-t7mbsr25 1166 29 , , , cord-024189-t7mbsr25 1166 30 and and CC cord-024189-t7mbsr25 1166 31 several several JJ cord-024189-t7mbsr25 1166 32 immune immune NN cord-024189-t7mbsr25 1166 33 - - HYPH cord-024189-t7mbsr25 1166 34 mediated mediate VBN cord-024189-t7mbsr25 1166 35 infl infl NN cord-024189-t7mbsr25 1166 36 ammatory ammatory NN cord-024189-t7mbsr25 1166 37 diseases disease NNS cord-024189-t7mbsr25 1166 38 , , , cord-024189-t7mbsr25 1166 39 including include VBG cord-024189-t7mbsr25 1166 40 rheumatoid rheumatoid NN cord-024189-t7mbsr25 1166 41 arthritis arthritis NN cord-024189-t7mbsr25 1166 42 . . . cord-024189-t7mbsr25 1167 1 Treatment treatment NN cord-024189-t7mbsr25 1167 2 of of IN cord-024189-t7mbsr25 1167 3 any any DT cord-024189-t7mbsr25 1167 4 associated associate VBN cord-024189-t7mbsr25 1167 5 disorder disorder NN cord-024189-t7mbsr25 1167 6 may may MD cord-024189-t7mbsr25 1167 7 benefi benefi VB cord-024189-t7mbsr25 1167 8 t t NNP cord-024189-t7mbsr25 1167 9 EED EED NNP cord-024189-t7mbsr25 1167 10 . . . cord-024189-t7mbsr25 1168 1 Dapsone Dapsone NNP cord-024189-t7mbsr25 1168 2 ( ( -LRB- cord-024189-t7mbsr25 1168 3 100 100 CD cord-024189-t7mbsr25 1168 4 mg mg NNP cord-024189-t7mbsr25 1168 5 / / SYM cord-024189-t7mbsr25 1168 6 day day NN cord-024189-t7mbsr25 1168 7 ) ) -RRB- cord-024189-t7mbsr25 1168 8 has have VBZ cord-024189-t7mbsr25 1168 9 been be VBN cord-024189-t7mbsr25 1168 10 reported report VBN cord-024189-t7mbsr25 1168 11 to to TO cord-024189-t7mbsr25 1168 12 be be VB cord-024189-t7mbsr25 1168 13 successful successful JJ cord-024189-t7mbsr25 1168 14 in in IN cord-024189-t7mbsr25 1168 15 some some DT cord-024189-t7mbsr25 1168 16 patients patient NNS cord-024189-t7mbsr25 1168 17 . . . cord-024189-t7mbsr25 1169 1 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1169 2 's 's POS cord-024189-t7mbsr25 1169 3 disease disease NN cord-024189-t7mbsr25 1169 4 ( ( -LRB- cord-024189-t7mbsr25 1169 5 KD KD NNP cord-024189-t7mbsr25 1169 6 ) ) -RRB- cord-024189-t7mbsr25 1169 7 , , , cord-024189-t7mbsr25 1169 8 once once RB cord-024189-t7mbsr25 1169 9 known know VBN cord-024189-t7mbsr25 1169 10 as as IN cord-024189-t7mbsr25 1169 11 mucocutaneous mucocutaneous JJ cord-024189-t7mbsr25 1169 12 lymph lymph NN cord-024189-t7mbsr25 1169 13 node node NN cord-024189-t7mbsr25 1169 14 syndrome syndrome NN cord-024189-t7mbsr25 1169 15 , , , cord-024189-t7mbsr25 1169 16 is be VBZ cord-024189-t7mbsr25 1169 17 a a DT cord-024189-t7mbsr25 1169 18 systemic systemic JJ cord-024189-t7mbsr25 1169 19 infl infl NN cord-024189-t7mbsr25 1169 20 ammatory ammatory NN cord-024189-t7mbsr25 1169 21 disorder disorder NN cord-024189-t7mbsr25 1169 22 occurring occur VBG cord-024189-t7mbsr25 1169 23 in in IN cord-024189-t7mbsr25 1169 24 children child NNS cord-024189-t7mbsr25 1169 25 that that WDT cord-024189-t7mbsr25 1169 26 is be VBZ cord-024189-t7mbsr25 1169 27 accompanied accompany VBN cord-024189-t7mbsr25 1169 28 by by IN cord-024189-t7mbsr25 1169 29 vasculitis vasculitis NN cord-024189-t7mbsr25 1169 30 and and CC cord-024189-t7mbsr25 1169 31 a a DT cord-024189-t7mbsr25 1169 32 risk risk NN cord-024189-t7mbsr25 1169 33 of of IN cord-024189-t7mbsr25 1169 34 coronary coronary JJ cord-024189-t7mbsr25 1169 35 artery artery NN cord-024189-t7mbsr25 1169 36 aneurysms aneurysm NNS cord-024189-t7mbsr25 1169 37 . . . cord-024189-t7mbsr25 1170 1 Other other JJ cord-024189-t7mbsr25 1170 2 typical typical JJ cord-024189-t7mbsr25 1170 3 features feature NNS cord-024189-t7mbsr25 1170 4 of of IN cord-024189-t7mbsr25 1170 5 KD KD NNP cord-024189-t7mbsr25 1170 6 include include VBP cord-024189-t7mbsr25 1170 7 spiking spike VBG cord-024189-t7mbsr25 1170 8 fevers fever NNS cord-024189-t7mbsr25 1170 9 , , , cord-024189-t7mbsr25 1170 10 cervical cervical JJ cord-024189-t7mbsr25 1170 11 lymphadenopathy lymphadenopathy NN cord-024189-t7mbsr25 1170 12 , , , cord-024189-t7mbsr25 1170 13 conjunctivitis conjunctivitis NN cord-024189-t7mbsr25 1170 14 , , , cord-024189-t7mbsr25 1170 15 erythematous erythematous JJ cord-024189-t7mbsr25 1170 16 changes change NNS cord-024189-t7mbsr25 1170 17 on on IN cord-024189-t7mbsr25 1170 18 the the DT cord-024189-t7mbsr25 1170 19 lips lip NNS cord-024189-t7mbsr25 1170 20 and and CC cord-024189-t7mbsr25 1170 21 in in IN cord-024189-t7mbsr25 1170 22 the the DT cord-024189-t7mbsr25 1170 23 oral oral JJ cord-024189-t7mbsr25 1170 24 cavity cavity NN cord-024189-t7mbsr25 1170 25 , , , cord-024189-t7mbsr25 1170 26 dryness dryness NN cord-024189-t7mbsr25 1170 27 and and CC cord-024189-t7mbsr25 1170 28 cracking cracking NN cord-024189-t7mbsr25 1170 29 of of IN cord-024189-t7mbsr25 1170 30 the the DT cord-024189-t7mbsr25 1170 31 lips lip NNS cord-024189-t7mbsr25 1170 32 , , , cord-024189-t7mbsr25 1170 33 a a DT cord-024189-t7mbsr25 1170 34 strawberry strawberry JJ cord-024189-t7mbsr25 1170 35 appearance appearance NN cord-024189-t7mbsr25 1170 36 to to IN cord-024189-t7mbsr25 1170 37 the the DT cord-024189-t7mbsr25 1170 38 tongue tongue NN cord-024189-t7mbsr25 1170 39 , , , cord-024189-t7mbsr25 1170 40 and and CC cord-024189-t7mbsr25 1170 41 a a DT cord-024189-t7mbsr25 1170 42 polymorphous polymorphous JJ cord-024189-t7mbsr25 1170 43 rash rash NN cord-024189-t7mbsr25 1170 44 . . . cord-024189-t7mbsr25 1171 1 Eighty eighty CD cord-024189-t7mbsr25 1171 2 percent percent NN cord-024189-t7mbsr25 1171 3 of of IN cord-024189-t7mbsr25 1171 4 KD KD NNP cord-024189-t7mbsr25 1171 5 cases case NNS cord-024189-t7mbsr25 1171 6 occur occur VBP cord-024189-t7mbsr25 1171 7 in in IN cord-024189-t7mbsr25 1171 8 children child NNS cord-024189-t7mbsr25 1171 9 less less JJR cord-024189-t7mbsr25 1171 10 than than IN cord-024189-t7mbsr25 1171 11 5 5 CD cord-024189-t7mbsr25 1171 12 years year NNS cord-024189-t7mbsr25 1171 13 of of IN cord-024189-t7mbsr25 1171 14 age age NN cord-024189-t7mbsr25 1171 15 . . . cord-024189-t7mbsr25 1172 1 Attempts attempt NNS cord-024189-t7mbsr25 1172 2 to to TO cord-024189-t7mbsr25 1172 3 link link VB cord-024189-t7mbsr25 1172 4 KD KD NNP cord-024189-t7mbsr25 1172 5 defi defi NNP cord-024189-t7mbsr25 1172 6 nitively nitively NN cord-024189-t7mbsr25 1172 7 to to IN cord-024189-t7mbsr25 1172 8 some some DT cord-024189-t7mbsr25 1172 9 types type NNS cord-024189-t7mbsr25 1172 10 of of IN cord-024189-t7mbsr25 1172 11 infection infection NN cord-024189-t7mbsr25 1172 12 , , , cord-024189-t7mbsr25 1172 13 particularly particularly RB cord-024189-t7mbsr25 1172 14 ones one NNS cord-024189-t7mbsr25 1172 15 associated associate VBN cord-024189-t7mbsr25 1172 16 with with IN cord-024189-t7mbsr25 1172 17 superantigens superantigens NNP cord-024189-t7mbsr25 1172 18 , , , cord-024189-t7mbsr25 1172 19 have have VBP cord-024189-t7mbsr25 1172 20 thus thus RB cord-024189-t7mbsr25 1172 21 far far RB cord-024189-t7mbsr25 1172 22 been be VBN cord-024189-t7mbsr25 1172 23 unsuccessful unsuccessful JJ cord-024189-t7mbsr25 1172 24 . . . cord-024189-t7mbsr25 1173 1 High high JJ cord-024189-t7mbsr25 1173 2 dose dose NN cord-024189-t7mbsr25 1173 3 aspirin aspirin NN cord-024189-t7mbsr25 1173 4 and and CC cord-024189-t7mbsr25 1173 5 intravenous intravenous JJ cord-024189-t7mbsr25 1173 6 immune immune JJ cord-024189-t7mbsr25 1173 7 globulin globulin NN cord-024189-t7mbsr25 1173 8 ( ( -LRB- cord-024189-t7mbsr25 1173 9 IVIG IVIG NNP cord-024189-t7mbsr25 1173 10 ) ) -RRB- cord-024189-t7mbsr25 1173 11 are be VBP cord-024189-t7mbsr25 1173 12 the the DT cord-024189-t7mbsr25 1173 13 cornerstones cornerstone NNS cord-024189-t7mbsr25 1173 14 of of IN cord-024189-t7mbsr25 1173 15 therapy therapy NN cord-024189-t7mbsr25 1173 16 in in IN cord-024189-t7mbsr25 1173 17 KD KD NNP cord-024189-t7mbsr25 1173 18 . . . cord-024189-t7mbsr25 1174 1 IVIG IVIG NNP cord-024189-t7mbsr25 1174 2 is be VBZ cord-024189-t7mbsr25 1174 3 essential essential JJ cord-024189-t7mbsr25 1174 4 to to IN cord-024189-t7mbsr25 1174 5 the the DT cord-024189-t7mbsr25 1174 6 prevention prevention NN cord-024189-t7mbsr25 1174 7 of of IN cord-024189-t7mbsr25 1174 8 coronary coronary JJ cord-024189-t7mbsr25 1174 9 aneurysms aneurysm NNS cord-024189-t7mbsr25 1174 10 . . . cord-024189-t7mbsr25 1175 1 Years year NNS cord-024189-t7mbsr25 1175 2 after after IN cord-024189-t7mbsr25 1175 3 KD KD NNP cord-024189-t7mbsr25 1175 4 has have VBZ cord-024189-t7mbsr25 1175 5 occurred occur VBN cord-024189-t7mbsr25 1175 6 during during IN cord-024189-t7mbsr25 1175 7 childhood childhood NN cord-024189-t7mbsr25 1175 8 years year NNS cord-024189-t7mbsr25 1175 9 , , , cord-024189-t7mbsr25 1175 10 some some DT cord-024189-t7mbsr25 1175 11 cases case NNS cord-024189-t7mbsr25 1175 12 of of IN cord-024189-t7mbsr25 1175 13 myocardial myocardial JJ cord-024189-t7mbsr25 1175 14 infarction infarction NN cord-024189-t7mbsr25 1175 15 caused cause VBN cord-024189-t7mbsr25 1175 16 by by IN cord-024189-t7mbsr25 1175 17 thrombosis thrombosis NN cord-024189-t7mbsr25 1175 18 of of IN cord-024189-t7mbsr25 1175 19 coronary coronary JJ cord-024189-t7mbsr25 1175 20 aneurysms aneurysm NNS cord-024189-t7mbsr25 1175 21 have have VBP cord-024189-t7mbsr25 1175 22 been be VBN cord-024189-t7mbsr25 1175 23 reported report VBN cord-024189-t7mbsr25 1175 24 . . . cord-024189-t7mbsr25 1176 1 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1176 2 's 's POS cord-024189-t7mbsr25 1176 3 disease disease NN cord-024189-t7mbsr25 1176 4 ( ( -LRB- cord-024189-t7mbsr25 1176 5 KD KD NNP cord-024189-t7mbsr25 1176 6 ) ) -RRB- cord-024189-t7mbsr25 1176 7 is be VBZ cord-024189-t7mbsr25 1176 8 a a DT cord-024189-t7mbsr25 1176 9 form form NN cord-024189-t7mbsr25 1176 10 of of IN cord-024189-t7mbsr25 1176 11 systemic systemic JJ cord-024189-t7mbsr25 1176 12 vasculitis vasculitis NN cord-024189-t7mbsr25 1176 13 that that WDT cord-024189-t7mbsr25 1176 14 occurs occur VBZ cord-024189-t7mbsr25 1176 15 in in IN cord-024189-t7mbsr25 1176 16 young young JJ cord-024189-t7mbsr25 1176 17 children child NNS cord-024189-t7mbsr25 1176 18 and and CC cord-024189-t7mbsr25 1176 19 may may MD cord-024189-t7mbsr25 1176 20 be be VB cord-024189-t7mbsr25 1176 21 associated associate VBN cord-024189-t7mbsr25 1176 22 with with IN cord-024189-t7mbsr25 1176 23 the the DT cord-024189-t7mbsr25 1176 24 development development NN cord-024189-t7mbsr25 1176 25 of of IN cord-024189-t7mbsr25 1176 26 coronary coronary JJ cord-024189-t7mbsr25 1176 27 arteritis arteritis NN cord-024189-t7mbsr25 1176 28 and and CC cord-024189-t7mbsr25 1176 29 aneurysm aneurysm NN cord-024189-t7mbsr25 1176 30 formation formation NN cord-024189-t7mbsr25 1176 31 ( ( -LRB- cord-024189-t7mbsr25 1176 32 Figure figure NN cord-024189-t7mbsr25 1176 33 21F-1 21f-1 CD cord-024189-t7mbsr25 1176 34 ) ) -RRB- cord-024189-t7mbsr25 1176 35 . . . cord-024189-t7mbsr25 1177 1 KD KD NNP cord-024189-t7mbsr25 1177 2 is be VBZ cord-024189-t7mbsr25 1177 3 the the DT cord-024189-t7mbsr25 1177 4 leading leading JJ cord-024189-t7mbsr25 1177 5 cause cause NN cord-024189-t7mbsr25 1177 6 of of IN cord-024189-t7mbsr25 1177 7 acquired acquire VBN cord-024189-t7mbsr25 1177 8 heart heart NN cord-024189-t7mbsr25 1177 9 disease disease NN cord-024189-t7mbsr25 1177 10 of of IN cord-024189-t7mbsr25 1177 11 children child NNS cord-024189-t7mbsr25 1177 12 in in IN cord-024189-t7mbsr25 1177 13 the the DT cord-024189-t7mbsr25 1177 14 United United NNP cord-024189-t7mbsr25 1177 15 States States NNP cord-024189-t7mbsr25 1177 16 . . . cord-024189-t7mbsr25 1178 1 This this DT cord-024189-t7mbsr25 1178 2 illness illness NN cord-024189-t7mbsr25 1178 3 , , , cord-024189-t7mbsr25 1178 4 fi fi NNP cord-024189-t7mbsr25 1178 5 rst rst NNP cord-024189-t7mbsr25 1178 6 recognized recognize VBN cord-024189-t7mbsr25 1178 7 to to TO cord-024189-t7mbsr25 1178 8 be be VB cord-024189-t7mbsr25 1178 9 a a DT cord-024189-t7mbsr25 1178 10 new new JJ cord-024189-t7mbsr25 1178 11 entity entity NN cord-024189-t7mbsr25 1178 12 by by IN cord-024189-t7mbsr25 1178 13 Tomasaku Tomasaku NNP cord-024189-t7mbsr25 1178 14 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1178 15 in in IN cord-024189-t7mbsr25 1178 16 Japan Japan NNP cord-024189-t7mbsr25 1178 17 in in IN cord-024189-t7mbsr25 1178 18 1967 1967 CD cord-024189-t7mbsr25 1178 19 ( ( -LRB- cord-024189-t7mbsr25 1178 20 1,2 1,2 CD cord-024189-t7mbsr25 1178 21 ) ) -RRB- cord-024189-t7mbsr25 1178 22 , , , cord-024189-t7mbsr25 1178 23 was be VBD cord-024189-t7mbsr25 1178 24 termed term VBN cord-024189-t7mbsr25 1178 25 for for IN cord-024189-t7mbsr25 1178 26 mucocutaneous mucocutaneous JJ cord-024189-t7mbsr25 1178 27 lymph lymph NNP cord-024189-t7mbsr25 1178 28 node node NNP cord-024189-t7mbsr25 1178 29 syndrome syndrome NN cord-024189-t7mbsr25 1178 30 ( ( -LRB- cord-024189-t7mbsr25 1178 31 MCLNS MCLNS NNP cord-024189-t7mbsr25 1178 32 ) ) -RRB- cord-024189-t7mbsr25 1178 33 until until IN cord-024189-t7mbsr25 1178 34 KD KD NNP cord-024189-t7mbsr25 1178 35 became become VBD cord-024189-t7mbsr25 1178 36 the the DT cord-024189-t7mbsr25 1178 37 accepted accepted JJ cord-024189-t7mbsr25 1178 38 designation designation NN cord-024189-t7mbsr25 1178 39 for for IN cord-024189-t7mbsr25 1178 40 this this DT cord-024189-t7mbsr25 1178 41 disorder disorder NN cord-024189-t7mbsr25 1178 42 ( ( -LRB- cord-024189-t7mbsr25 1178 43 3 3 CD cord-024189-t7mbsr25 1178 44 ) ) -RRB- cord-024189-t7mbsr25 1178 45 . . . cord-024189-t7mbsr25 1179 1 Although although IN cord-024189-t7mbsr25 1179 2 the the DT cord-024189-t7mbsr25 1179 3 disorder disorder NN cord-024189-t7mbsr25 1179 4 was be VBD cord-024189-t7mbsr25 1179 5 named name VBN cord-024189-t7mbsr25 1179 6 after after IN cord-024189-t7mbsr25 1179 7 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1179 8 , , , cord-024189-t7mbsr25 1179 9 at at RB cord-024189-t7mbsr25 1179 10 least least RBS cord-024189-t7mbsr25 1179 11 one one CD cord-024189-t7mbsr25 1179 12 previous previous JJ cord-024189-t7mbsr25 1179 13 case case NN cord-024189-t7mbsr25 1179 14 exists exist VBZ cord-024189-t7mbsr25 1179 15 in in IN cord-024189-t7mbsr25 1179 16 the the DT cord-024189-t7mbsr25 1179 17 medical medical JJ cord-024189-t7mbsr25 1179 18 literature literature NN cord-024189-t7mbsr25 1179 19 ( ( -LRB- cord-024189-t7mbsr25 1179 20 4 4 CD cord-024189-t7mbsr25 1179 21 ) ) -RRB- cord-024189-t7mbsr25 1179 22 . . . cord-024189-t7mbsr25 1180 1 This this DT cord-024189-t7mbsr25 1180 2 case case NN cord-024189-t7mbsr25 1180 3 , , , cord-024189-t7mbsr25 1180 4 recounted recount VBD cord-024189-t7mbsr25 1180 5 in in IN cord-024189-t7mbsr25 1180 6 detail detail NN cord-024189-t7mbsr25 1180 7 below below RB cord-024189-t7mbsr25 1180 8 , , , cord-024189-t7mbsr25 1180 9 is be VBZ cord-024189-t7mbsr25 1180 10 classic classic JJ cord-024189-t7mbsr25 1180 11 in in IN cord-024189-t7mbsr25 1180 12 its -PRON- PRP$ cord-024189-t7mbsr25 1180 13 clinical clinical JJ cord-024189-t7mbsr25 1180 14 features feature NNS cord-024189-t7mbsr25 1180 15 of of IN cord-024189-t7mbsr25 1180 16 KD KD NNP cord-024189-t7mbsr25 1180 17 . . . cord-024189-t7mbsr25 1181 1 A a DT cord-024189-t7mbsr25 1181 2 5-year 5-year CD cord-024189-t7mbsr25 1181 3 - - HYPH cord-024189-t7mbsr25 1181 4 old old JJ cord-024189-t7mbsr25 1181 5 girl girl NN cord-024189-t7mbsr25 1181 6 presented present VBN cord-024189-t7mbsr25 1181 7 with with IN cord-024189-t7mbsr25 1181 8 a a DT cord-024189-t7mbsr25 1181 9 sore sore JJ cord-024189-t7mbsr25 1181 10 throat throat NN cord-024189-t7mbsr25 1181 11 , , , cord-024189-t7mbsr25 1181 12 a a DT cord-024189-t7mbsr25 1181 13 fever fever NN cord-024189-t7mbsr25 1181 14 to to IN cord-024189-t7mbsr25 1181 15 105 105 CD cord-024189-t7mbsr25 1181 16 ° ° NN cord-024189-t7mbsr25 1181 17 F f NN cord-024189-t7mbsr25 1181 18 , , , cord-024189-t7mbsr25 1181 19 and and CC cord-024189-t7mbsr25 1181 20 an an DT cord-024189-t7mbsr25 1181 21 erythematous erythematous JJ cord-024189-t7mbsr25 1181 22 rash rash NN cord-024189-t7mbsr25 1181 23 over over IN cord-024189-t7mbsr25 1181 24 her -PRON- PRP$ cord-024189-t7mbsr25 1181 25 trunk trunk NN cord-024189-t7mbsr25 1181 26 , , , cord-024189-t7mbsr25 1181 27 appearing appear VBG cord-024189-t7mbsr25 1181 28 " " `` cord-024189-t7mbsr25 1181 29 desperately desperately RB cord-024189-t7mbsr25 1181 30 and and CC cord-024189-t7mbsr25 1181 31 acutely acutely RB cord-024189-t7mbsr25 1181 32 ill ill RB cord-024189-t7mbsr25 1181 33 " " '' cord-024189-t7mbsr25 1181 34 ( ( -LRB- cord-024189-t7mbsr25 1181 35 4 4 CD cord-024189-t7mbsr25 1181 36 ) ) -RRB- cord-024189-t7mbsr25 1181 37 . . . cord-024189-t7mbsr25 1182 1 Oropharyngeal oropharyngeal JJ cord-024189-t7mbsr25 1182 2 lesions lesion NNS cord-024189-t7mbsr25 1182 3 included include VBD cord-024189-t7mbsr25 1182 4 an an DT cord-024189-t7mbsr25 1182 5 aphthous aphthous JJ cord-024189-t7mbsr25 1182 6 stomatitis stomatitis NN cord-024189-t7mbsr25 1182 7 , , , cord-024189-t7mbsr25 1182 8 erythematous erythematous JJ cord-024189-t7mbsr25 1182 9 lesions lesion NNS cord-024189-t7mbsr25 1182 10 of of IN cord-024189-t7mbsr25 1182 11 the the DT cord-024189-t7mbsr25 1182 12 hard hard JJ cord-024189-t7mbsr25 1182 13 palate palate NN cord-024189-t7mbsr25 1182 14 , , , cord-024189-t7mbsr25 1182 15 and and CC cord-024189-t7mbsr25 1182 16 prominent prominent JJ cord-024189-t7mbsr25 1182 17 lingual lingual JJ cord-024189-t7mbsr25 1182 18 papillae papilla NNS cord-024189-t7mbsr25 1182 19 . . . cord-024189-t7mbsr25 1183 1 On on IN cord-024189-t7mbsr25 1183 2 the the DT cord-024189-t7mbsr25 1183 3 fi fi NNP cord-024189-t7mbsr25 1183 4 fth fth NNP cord-024189-t7mbsr25 1183 5 hospital hospital NNP cord-024189-t7mbsr25 1183 6 day day NN cord-024189-t7mbsr25 1183 7 the the DT cord-024189-t7mbsr25 1183 8 hectic hectic JJ cord-024189-t7mbsr25 1183 9 fevers fever NNS cord-024189-t7mbsr25 1183 10 ceased cease VBD cord-024189-t7mbsr25 1183 11 , , , cord-024189-t7mbsr25 1183 12 but but CC cord-024189-t7mbsr25 1183 13 low low JJ cord-024189-t7mbsr25 1183 14 - - HYPH cord-024189-t7mbsr25 1183 15 grade grade NN cord-024189-t7mbsr25 1183 16 fevers fever NNS cord-024189-t7mbsr25 1183 17 and and CC cord-024189-t7mbsr25 1183 18 tachycardia tachycardia NN cord-024189-t7mbsr25 1183 19 to to IN cord-024189-t7mbsr25 1183 20 140 140 CD cord-024189-t7mbsr25 1183 21 beats beat NNS cord-024189-t7mbsr25 1183 22 per per IN cord-024189-t7mbsr25 1183 23 minute minute NN cord-024189-t7mbsr25 1183 24 persisted persist VBD cord-024189-t7mbsr25 1183 25 . . . cord-024189-t7mbsr25 1184 1 The the DT cord-024189-t7mbsr25 1184 2 skin skin NN cord-024189-t7mbsr25 1184 3 of of IN cord-024189-t7mbsr25 1184 4 her -PRON- PRP$ cord-024189-t7mbsr25 1184 5 fi fi NNP cord-024189-t7mbsr25 1184 6 ngers ngers NNP cord-024189-t7mbsr25 1184 7 desquamated desquamate VBN cord-024189-t7mbsr25 1184 8 , , , cord-024189-t7mbsr25 1184 9 but but CC cord-024189-t7mbsr25 1184 10 over over IN cord-024189-t7mbsr25 1184 11 the the DT cord-024189-t7mbsr25 1184 12 ensuing ensue VBG cord-024189-t7mbsr25 1184 13 weeks week NNS cord-024189-t7mbsr25 1184 14 she -PRON- PRP cord-024189-t7mbsr25 1184 15 improved improve VBD cord-024189-t7mbsr25 1184 16 steadily steadily RB cord-024189-t7mbsr25 1184 17 . . . cord-024189-t7mbsr25 1185 1 One one CD cord-024189-t7mbsr25 1185 2 month month NN cord-024189-t7mbsr25 1185 3 after after IN cord-024189-t7mbsr25 1185 4 admission admission NN cord-024189-t7mbsr25 1185 5 , , , cord-024189-t7mbsr25 1185 6 however however RB cord-024189-t7mbsr25 1185 7 , , , cord-024189-t7mbsr25 1185 8 she -PRON- PRP cord-024189-t7mbsr25 1185 9 developed develop VBD cord-024189-t7mbsr25 1185 10 acute acute JJ cord-024189-t7mbsr25 1185 11 chest chest NN cord-024189-t7mbsr25 1185 12 pain pain NN cord-024189-t7mbsr25 1185 13 , , , cord-024189-t7mbsr25 1185 14 shortness shortness NN cord-024189-t7mbsr25 1185 15 of of IN cord-024189-t7mbsr25 1185 16 breath breath NN cord-024189-t7mbsr25 1185 17 , , , cord-024189-t7mbsr25 1185 18 and and CC cord-024189-t7mbsr25 1185 19 expired expire VBD cord-024189-t7mbsr25 1185 20 . . . cord-024189-t7mbsr25 1186 1 A a DT cord-024189-t7mbsr25 1186 2 postmortem postmortem JJ cord-024189-t7mbsr25 1186 3 examination examination NN cord-024189-t7mbsr25 1186 4 revealed reveal VBD cord-024189-t7mbsr25 1186 5 blood blood NN cord-024189-t7mbsr25 1186 6 and and CC cord-024189-t7mbsr25 1186 7 clots clot NNS cord-024189-t7mbsr25 1186 8 in in IN cord-024189-t7mbsr25 1186 9 the the DT cord-024189-t7mbsr25 1186 10 pericardial pericardial JJ cord-024189-t7mbsr25 1186 11 space space NN cord-024189-t7mbsr25 1186 12 , , , cord-024189-t7mbsr25 1186 13 and and CC cord-024189-t7mbsr25 1186 14 several several JJ cord-024189-t7mbsr25 1186 15 large large JJ cord-024189-t7mbsr25 1186 16 aneurysms aneurysm NNS cord-024189-t7mbsr25 1186 17 along along IN cord-024189-t7mbsr25 1186 18 the the DT cord-024189-t7mbsr25 1186 19 epicardial epicardial JJ cord-024189-t7mbsr25 1186 20 vessels vessel NNS cord-024189-t7mbsr25 1186 21 . . . cord-024189-t7mbsr25 1187 1 One one CD cord-024189-t7mbsr25 1187 2 aneurysm aneurysm NN cord-024189-t7mbsr25 1187 3 , , , cord-024189-t7mbsr25 1187 4 the the DT cord-024189-t7mbsr25 1187 5 size size NN cord-024189-t7mbsr25 1187 6 of of IN cord-024189-t7mbsr25 1187 7 a a DT cord-024189-t7mbsr25 1187 8 large large JJ cord-024189-t7mbsr25 1187 9 ripe ripe JJ cord-024189-t7mbsr25 1187 10 cherry cherry NN cord-024189-t7mbsr25 1187 11 in in IN cord-024189-t7mbsr25 1187 12 the the DT cord-024189-t7mbsr25 1187 13 left left JJ cord-024189-t7mbsr25 1187 14 coronary coronary JJ cord-024189-t7mbsr25 1187 15 artery artery NN cord-024189-t7mbsr25 1187 16 , , , cord-024189-t7mbsr25 1187 17 was be VBD cord-024189-t7mbsr25 1187 18 the the DT cord-024189-t7mbsr25 1187 19 site site NN cord-024189-t7mbsr25 1187 20 of of IN cord-024189-t7mbsr25 1187 21 hemorrhage hemorrhage NN cord-024189-t7mbsr25 1187 22 into into IN cord-024189-t7mbsr25 1187 23 the the DT cord-024189-t7mbsr25 1187 24 pericardium pericardium NN cord-024189-t7mbsr25 1187 25 . . . cord-024189-t7mbsr25 1188 1 Although although IN cord-024189-t7mbsr25 1188 2 the the DT cord-024189-t7mbsr25 1188 3 microscopic microscopic JJ cord-024189-t7mbsr25 1188 4 appearance appearance NN cord-024189-t7mbsr25 1188 5 of of IN cord-024189-t7mbsr25 1188 6 the the DT cord-024189-t7mbsr25 1188 7 disease disease NN cord-024189-t7mbsr25 1188 8 was be VBD cord-024189-t7mbsr25 1188 9 typical typical JJ cord-024189-t7mbsr25 1188 10 of of IN cord-024189-t7mbsr25 1188 11 periarteritis periarteritis NNP cord-024189-t7mbsr25 1188 12 nodosa nodosa NNP cord-024189-t7mbsr25 1188 13 ( ( -LRB- cord-024189-t7mbsr25 1188 14 i.e. i.e. FW cord-024189-t7mbsr25 1188 15 , , , cord-024189-t7mbsr25 1188 16 PAN PAN NNP cord-024189-t7mbsr25 1188 17 ; ; : cord-024189-t7mbsr25 1188 18 see see VB cord-024189-t7mbsr25 1188 19 Chapter chapter NN cord-024189-t7mbsr25 1188 20 21B 21b CD cord-024189-t7mbsr25 1188 21 ) ) -RRB- cord-024189-t7mbsr25 1188 22 , , , cord-024189-t7mbsr25 1188 23 no no DT cord-024189-t7mbsr25 1188 24 hepatic hepatic JJ cord-024189-t7mbsr25 1188 25 or or CC cord-024189-t7mbsr25 1188 26 renal renal JJ cord-024189-t7mbsr25 1188 27 infarctions infarction NNS cord-024189-t7mbsr25 1188 28 were be VBD cord-024189-t7mbsr25 1188 29 present present JJ cord-024189-t7mbsr25 1188 30 . . . cord-024189-t7mbsr25 1189 1 Indeed indeed RB cord-024189-t7mbsr25 1189 2 , , , cord-024189-t7mbsr25 1189 3 among among IN cord-024189-t7mbsr25 1189 4 the the DT cord-024189-t7mbsr25 1189 5 internal internal JJ cord-024189-t7mbsr25 1189 6 organs organ NNS cord-024189-t7mbsr25 1189 7 the the DT cord-024189-t7mbsr25 1189 8 heart heart NN cord-024189-t7mbsr25 1189 9 alone alone RB cord-024189-t7mbsr25 1189 10 was be VBD cord-024189-t7mbsr25 1189 11 involved involve VBN cord-024189-t7mbsr25 1189 12 . . . cord-024189-t7mbsr25 1190 1 The the DT cord-024189-t7mbsr25 1190 2 child child NN cord-024189-t7mbsr25 1190 3 's 's POS cord-024189-t7mbsr25 1190 4 death death NN cord-024189-t7mbsr25 1190 5 was be VBD cord-024189-t7mbsr25 1190 6 attributed attribute VBN cord-024189-t7mbsr25 1190 7 to to IN cord-024189-t7mbsr25 1190 8 an an DT cord-024189-t7mbsr25 1190 9 atypical atypical JJ cord-024189-t7mbsr25 1190 10 case case NN cord-024189-t7mbsr25 1190 11 of of IN cord-024189-t7mbsr25 1190 12 " " `` cord-024189-t7mbsr25 1190 13 infantile infantile JJ cord-024189-t7mbsr25 1190 14 periarteritis periarteritis NN cord-024189-t7mbsr25 1190 15 nodosa nodosa RB cord-024189-t7mbsr25 1190 16 , , , cord-024189-t7mbsr25 1190 17 " " '' cord-024189-t7mbsr25 1190 18 now now RB cord-024189-t7mbsr25 1190 19 recognized recognize VBN cord-024189-t7mbsr25 1190 20 as as IN cord-024189-t7mbsr25 1190 21 KD KD NNP cord-024189-t7mbsr25 1190 22 . . . cord-024189-t7mbsr25 1191 1 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1191 2 's 's POS cord-024189-t7mbsr25 1191 3 disease disease NN cord-024189-t7mbsr25 1191 4 strikes strike VBZ cord-024189-t7mbsr25 1191 5 quickly quickly RB cord-024189-t7mbsr25 1191 6 , , , cord-024189-t7mbsr25 1191 7 runs run VBZ cord-024189-t7mbsr25 1191 8 a a DT cord-024189-t7mbsr25 1191 9 furious furious JJ cord-024189-t7mbsr25 1191 10 course course NN cord-024189-t7mbsr25 1191 11 over over IN cord-024189-t7mbsr25 1191 12 a a DT cord-024189-t7mbsr25 1191 13 few few JJ cord-024189-t7mbsr25 1191 14 weeks week NNS cord-024189-t7mbsr25 1191 15 , , , cord-024189-t7mbsr25 1191 16 and and CC cord-024189-t7mbsr25 1191 17 then then RB cord-024189-t7mbsr25 1191 18 apparently apparently RB cord-024189-t7mbsr25 1191 19 resolves resolve VBZ cord-024189-t7mbsr25 1191 20 . . . cord-024189-t7mbsr25 1192 1 In in IN cord-024189-t7mbsr25 1192 2 all all DT cord-024189-t7mbsr25 1192 3 50 50 CD cord-024189-t7mbsr25 1192 4 of of IN cord-024189-t7mbsr25 1192 5 the the DT cord-024189-t7mbsr25 1192 6 patients patient NNS cord-024189-t7mbsr25 1192 7 described describe VBN cord-024189-t7mbsr25 1192 8 initially initially RB cord-024189-t7mbsr25 1192 9 by by IN cord-024189-t7mbsr25 1192 10 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1192 11 , , , cord-024189-t7mbsr25 1192 12 the the DT cord-024189-t7mbsr25 1192 13 symptoms symptom NNS cord-024189-t7mbsr25 1192 14 resolved resolve VBN cord-024189-t7mbsr25 1192 15 without without IN cord-024189-t7mbsr25 1192 16 sequelae sequela NNS cord-024189-t7mbsr25 1192 17 within within IN cord-024189-t7mbsr25 1192 18 1 1 CD cord-024189-t7mbsr25 1192 19 month month NN cord-024189-t7mbsr25 1192 20 . . . cord-024189-t7mbsr25 1193 1 In in IN cord-024189-t7mbsr25 1193 2 subsequent subsequent JJ cord-024189-t7mbsr25 1193 3 years year NNS cord-024189-t7mbsr25 1193 4 , , , cord-024189-t7mbsr25 1193 5 however however RB cord-024189-t7mbsr25 1193 6 , , , cord-024189-t7mbsr25 1193 7 mortality mortality NN cord-024189-t7mbsr25 1193 8 from from IN cord-024189-t7mbsr25 1193 9 cardiac cardiac JJ cord-024189-t7mbsr25 1193 10 complications complication NNS cord-024189-t7mbsr25 1193 11 ( ( -LRB- cord-024189-t7mbsr25 1193 12 usually usually RB cord-024189-t7mbsr25 1193 13 coronary coronary JJ cord-024189-t7mbsr25 1193 14 artery artery NN cord-024189-t7mbsr25 1193 15 thrombosis thrombosis NN cord-024189-t7mbsr25 1193 16 ) ) -RRB- cord-024189-t7mbsr25 1193 17 was be VBD cord-024189-t7mbsr25 1193 18 reported report VBN cord-024189-t7mbsr25 1193 19 ( ( -LRB- cord-024189-t7mbsr25 1193 20 5 5 CD cord-024189-t7mbsr25 1193 21 , , , cord-024189-t7mbsr25 1193 22 6 6 CD cord-024189-t7mbsr25 1193 23 ) ) -RRB- cord-024189-t7mbsr25 1193 24 . . . cord-024189-t7mbsr25 1194 1 Cardiac cardiac JJ cord-024189-t7mbsr25 1194 2 complications complication NNS cord-024189-t7mbsr25 1194 3 of of IN cord-024189-t7mbsr25 1194 4 KD KD NNP cord-024189-t7mbsr25 1194 5 result result NN cord-024189-t7mbsr25 1194 6 from from IN cord-024189-t7mbsr25 1194 7 a a DT cord-024189-t7mbsr25 1194 8 severe severe JJ cord-024189-t7mbsr25 1194 9 panvasculitis panvasculitis NN cord-024189-t7mbsr25 1194 10 , , , cord-024189-t7mbsr25 1194 11 leading lead VBG cord-024189-t7mbsr25 1194 12 to to IN cord-024189-t7mbsr25 1194 13 narrowing narrowing NN cord-024189-t7mbsr25 1194 14 of of IN cord-024189-t7mbsr25 1194 15 the the DT cord-024189-t7mbsr25 1194 16 coronary coronary JJ cord-024189-t7mbsr25 1194 17 lumina lumina NNP cord-024189-t7mbsr25 1194 18 by by IN cord-024189-t7mbsr25 1194 19 the the DT cord-024189-t7mbsr25 1194 20 migration migration NN cord-024189-t7mbsr25 1194 21 of of IN cord-024189-t7mbsr25 1194 22 myointimal myointimal JJ cord-024189-t7mbsr25 1194 23 cells cell NNS cord-024189-t7mbsr25 1194 24 from from IN cord-024189-t7mbsr25 1194 25 the the DT cord-024189-t7mbsr25 1194 26 media medium NNS cord-024189-t7mbsr25 1194 27 through through IN cord-024189-t7mbsr25 1194 28 the the DT cord-024189-t7mbsr25 1194 29 fragmented fragmented JJ cord-024189-t7mbsr25 1194 30 internal internal JJ cord-024189-t7mbsr25 1194 31 elastic elastic JJ cord-024189-t7mbsr25 1194 32 lamina lamina NN cord-024189-t7mbsr25 1194 33 . . . cord-024189-t7mbsr25 1195 1 Although although IN cord-024189-t7mbsr25 1195 2 catastrophic catastrophic JJ cord-024189-t7mbsr25 1195 3 heart heart NN cord-024189-t7mbsr25 1195 4 complications complication NNS cord-024189-t7mbsr25 1195 5 occur occur VBP cord-024189-t7mbsr25 1195 6 in in IN cord-024189-t7mbsr25 1195 7 only only RB cord-024189-t7mbsr25 1195 8 a a DT cord-024189-t7mbsr25 1195 9 small small JJ cord-024189-t7mbsr25 1195 10 minority minority NN cord-024189-t7mbsr25 1195 11 of of IN cord-024189-t7mbsr25 1195 12 patients patient NNS cord-024189-t7mbsr25 1195 13 ( ( -LRB- cord-024189-t7mbsr25 1195 14 < < NNP cord-024189-t7mbsr25 1195 15 5 5 CD cord-024189-t7mbsr25 1195 16 % % NN cord-024189-t7mbsr25 1195 17 ) ) -RRB- cord-024189-t7mbsr25 1195 18 , , , cord-024189-t7mbsr25 1195 19 the the DT cord-024189-t7mbsr25 1195 20 preponderance preponderance NN cord-024189-t7mbsr25 1195 21 of of IN cord-024189-t7mbsr25 1195 22 patients patient NNS cord-024189-t7mbsr25 1195 23 with with IN cord-024189-t7mbsr25 1195 24 KD KD NNP cord-024189-t7mbsr25 1195 25 appear appear VBP cord-024189-t7mbsr25 1195 26 to to TO cord-024189-t7mbsr25 1195 27 have have VB cord-024189-t7mbsr25 1195 28 at at IN cord-024189-t7mbsr25 1195 29 least least JJS cord-024189-t7mbsr25 1195 30 some some DT cord-024189-t7mbsr25 1195 31 cardiac cardiac JJ cord-024189-t7mbsr25 1195 32 involvement involvement NN cord-024189-t7mbsr25 1195 33 . . . cord-024189-t7mbsr25 1196 1 Heart heart NN cord-024189-t7mbsr25 1196 2 lesions lesion NNS cord-024189-t7mbsr25 1196 3 may may MD cord-024189-t7mbsr25 1196 4 include include VB cord-024189-t7mbsr25 1196 5 myocarditis myocarditis NN cord-024189-t7mbsr25 1196 6 , , , cord-024189-t7mbsr25 1196 7 pericarditis pericarditis NN cord-024189-t7mbsr25 1196 8 , , , cord-024189-t7mbsr25 1196 9 aneurysmal aneurysmal JJ cord-024189-t7mbsr25 1196 10 dilatation dilatation NN cord-024189-t7mbsr25 1196 11 and and CC cord-024189-t7mbsr25 1196 12 thrombosis thrombosis NN cord-024189-t7mbsr25 1196 13 of of IN cord-024189-t7mbsr25 1196 14 the the DT cord-024189-t7mbsr25 1196 15 coronary coronary JJ cord-024189-t7mbsr25 1196 16 arteries artery NNS cord-024189-t7mbsr25 1196 17 ( ( -LRB- cord-024189-t7mbsr25 1196 18 Figure figure NN cord-024189-t7mbsr25 1196 19 21F-2 21f-2 CD cord-024189-t7mbsr25 1196 20 ) ) -RRB- cord-024189-t7mbsr25 1196 21 , , , cord-024189-t7mbsr25 1196 22 and and CC cord-024189-t7mbsr25 1196 23 myocardial myocardial JJ cord-024189-t7mbsr25 1196 24 infarction infarction NN cord-024189-t7mbsr25 1196 25 . . . cord-024189-t7mbsr25 1197 1 The the DT cord-024189-t7mbsr25 1197 2 tropism tropism NN cord-024189-t7mbsr25 1197 3 of of IN cord-024189-t7mbsr25 1197 4 the the DT cord-024189-t7mbsr25 1197 5 vascular vascular JJ cord-024189-t7mbsr25 1197 6 infl infl NN cord-024189-t7mbsr25 1197 7 ammation ammation NN cord-024189-t7mbsr25 1197 8 for for IN cord-024189-t7mbsr25 1197 9 coronary coronary JJ cord-024189-t7mbsr25 1197 10 arteries artery NNS cord-024189-t7mbsr25 1197 11 and and CC cord-024189-t7mbsr25 1197 12 its -PRON- PRP$ cord-024189-t7mbsr25 1197 13 unusual unusual JJ cord-024189-t7mbsr25 1197 14 propensity propensity NN cord-024189-t7mbsr25 1197 15 to to TO cord-024189-t7mbsr25 1197 16 cause cause VB cord-024189-t7mbsr25 1197 17 aneurysm aneurysm NN cord-024189-t7mbsr25 1197 18 formation formation NN cord-024189-t7mbsr25 1197 19 remain remain VBP cord-024189-t7mbsr25 1197 20 unexplained unexplained JJ cord-024189-t7mbsr25 1197 21 . . . cord-024189-t7mbsr25 1198 1 In in IN cord-024189-t7mbsr25 1198 2 addition addition NN cord-024189-t7mbsr25 1198 3 to to IN cord-024189-t7mbsr25 1198 4 the the DT cord-024189-t7mbsr25 1198 5 cardiac cardiac NN cord-024189-t7mbsr25 1198 6 fi fi NNP cord-024189-t7mbsr25 1198 7 ndings nding NNS cord-024189-t7mbsr25 1198 8 , , , cord-024189-t7mbsr25 1198 9 KD KD NNP cord-024189-t7mbsr25 1198 10 is be VBZ cord-024189-t7mbsr25 1198 11 associated associate VBN cord-024189-t7mbsr25 1198 12 with with IN cord-024189-t7mbsr25 1198 13 a a DT cord-024189-t7mbsr25 1198 14 number number NN cord-024189-t7mbsr25 1198 15 of of IN cord-024189-t7mbsr25 1198 16 other other JJ cord-024189-t7mbsr25 1198 17 dramatic dramatic JJ cord-024189-t7mbsr25 1198 18 clinical clinical JJ cord-024189-t7mbsr25 1198 19 fi fi NN cord-024189-t7mbsr25 1198 20 ndings nding NNS cord-024189-t7mbsr25 1198 21 ( ( -LRB- cord-024189-t7mbsr25 1198 22 Table Table NNP cord-024189-t7mbsr25 1198 23 _SP cord-024189-t7mbsr25 1198 24 21F-1 21f-1 CD cord-024189-t7mbsr25 1198 25 ) ) -RRB- cord-024189-t7mbsr25 1198 26 . . . cord-024189-t7mbsr25 1199 1 Spiking spike VBG cord-024189-t7mbsr25 1199 2 fevers fever NNS cord-024189-t7mbsr25 1199 3 may may MD cord-024189-t7mbsr25 1199 4 last last VB cord-024189-t7mbsr25 1199 5 for for IN cord-024189-t7mbsr25 1199 6 5 5 CD cord-024189-t7mbsr25 1199 7 days day NNS cord-024189-t7mbsr25 1199 8 or or CC cord-024189-t7mbsr25 1199 9 more more JJR cord-024189-t7mbsr25 1199 10 . . . cord-024189-t7mbsr25 1200 1 The the DT cord-024189-t7mbsr25 1200 2 conjunctivae conjunctiva NNS cord-024189-t7mbsr25 1200 3 , , , cord-024189-t7mbsr25 1200 4 generally generally RB cord-024189-t7mbsr25 1200 5 infl infl NNP cord-024189-t7mbsr25 1200 6 amed amed NNP cord-024189-t7mbsr25 1200 7 in in IN cord-024189-t7mbsr25 1200 8 a a DT cord-024189-t7mbsr25 1200 9 nonpurulent nonpurulent NN cord-024189-t7mbsr25 1200 10 manner manner NN cord-024189-t7mbsr25 1200 11 , , , cord-024189-t7mbsr25 1200 12 are be VBP cord-024189-t7mbsr25 1200 13 accompanied accompany VBN cord-024189-t7mbsr25 1200 14 by by IN cord-024189-t7mbsr25 1200 15 erythematous erythematous JJ cord-024189-t7mbsr25 1200 16 changes change NNS cord-024189-t7mbsr25 1200 17 on on IN cord-024189-t7mbsr25 1200 18 the the DT cord-024189-t7mbsr25 1200 19 lips lip NNS cord-024189-t7mbsr25 1200 20 and and CC cord-024189-t7mbsr25 1200 21 in in IN cord-024189-t7mbsr25 1200 22 the the DT cord-024189-t7mbsr25 1200 23 oral oral JJ cord-024189-t7mbsr25 1200 24 cavity cavity NN cord-024189-t7mbsr25 1200 25 [ [ -LRB- cord-024189-t7mbsr25 1200 26 Figure figure NN cord-024189-t7mbsr25 1200 27 21F-3(A 21f-3(a CD cord-024189-t7mbsr25 1200 28 ) ) -RRB- cord-024189-t7mbsr25 1200 29 ] ] -RRB- cord-024189-t7mbsr25 1200 30 . . . cord-024189-t7mbsr25 1201 1 The the DT cord-024189-t7mbsr25 1201 2 lips lip NNS cord-024189-t7mbsr25 1201 3 become become VBP cord-024189-t7mbsr25 1201 4 dry dry JJ cord-024189-t7mbsr25 1201 5 and and CC cord-024189-t7mbsr25 1201 6 cracked crack VBN cord-024189-t7mbsr25 1201 7 [ [ -LRB- cord-024189-t7mbsr25 1201 8 Figure figure NN cord-024189-t7mbsr25 1201 9 21F-3(B 21f-3(b CD cord-024189-t7mbsr25 1201 10 ) ) -RRB- cord-024189-t7mbsr25 1201 11 ] ] -RRB- cord-024189-t7mbsr25 1201 12 , , , cord-024189-t7mbsr25 1201 13 with with IN cord-024189-t7mbsr25 1201 14 a a DT cord-024189-t7mbsr25 1201 15 diffuse diffuse JJ cord-024189-t7mbsr25 1201 16 reddening reddening NN cord-024189-t7mbsr25 1201 17 of of IN cord-024189-t7mbsr25 1201 18 the the DT cord-024189-t7mbsr25 1201 19 oropharyngeal oropharyngeal JJ cord-024189-t7mbsr25 1201 20 area area NN cord-024189-t7mbsr25 1201 21 and and CC cord-024189-t7mbsr25 1201 22 a a DT cord-024189-t7mbsr25 1201 23 strawberry strawberry JJ cord-024189-t7mbsr25 1201 24 appearance appearance NN cord-024189-t7mbsr25 1201 25 to to IN cord-024189-t7mbsr25 1201 26 the the DT cord-024189-t7mbsr25 1201 27 tongue tongue NN cord-024189-t7mbsr25 1201 28 ( ( -LRB- cord-024189-t7mbsr25 1201 29 Figure figure NN cord-024189-t7mbsr25 1201 30 21F-4 21f-4 CD cord-024189-t7mbsr25 1201 31 ) ) -RRB- cord-024189-t7mbsr25 1201 32 . . . cord-024189-t7mbsr25 1202 1 A a DT cord-024189-t7mbsr25 1202 2 polymorphous polymorphous JJ cord-024189-t7mbsr25 1202 3 rash rash NN cord-024189-t7mbsr25 1202 4 typically typically RB cord-024189-t7mbsr25 1202 5 involves involve VBZ cord-024189-t7mbsr25 1202 6 the the DT cord-024189-t7mbsr25 1202 7 trunk trunk NN cord-024189-t7mbsr25 1202 8 [ [ -LRB- cord-024189-t7mbsr25 1202 9 Figure figure NN cord-024189-t7mbsr25 1202 10 _SP cord-024189-t7mbsr25 1202 11 21F 21f NN cord-024189-t7mbsr25 1202 12 -3(A -3(A : cord-024189-t7mbsr25 1202 13 ) ) -RRB- cord-024189-t7mbsr25 1202 14 ] ] -RRB- cord-024189-t7mbsr25 1202 15 , , , cord-024189-t7mbsr25 1202 16 and and CC cord-024189-t7mbsr25 1202 17 there there EX cord-024189-t7mbsr25 1202 18 may may MD cord-024189-t7mbsr25 1202 19 be be VB cord-024189-t7mbsr25 1202 20 extensive extensive JJ cord-024189-t7mbsr25 1202 21 lymphadenopathy lymphadenopathy NN cord-024189-t7mbsr25 1202 22 in in IN cord-024189-t7mbsr25 1202 23 the the DT cord-024189-t7mbsr25 1202 24 neck neck NN cord-024189-t7mbsr25 1202 25 region region NN cord-024189-t7mbsr25 1202 26 . . . cord-024189-t7mbsr25 1203 1 The the DT cord-024189-t7mbsr25 1203 2 palms palm NNS cord-024189-t7mbsr25 1203 3 and and CC cord-024189-t7mbsr25 1203 4 soles sol NNS cord-024189-t7mbsr25 1203 5 become become VBP cord-024189-t7mbsr25 1203 6 erythematous erythematous JJ cord-024189-t7mbsr25 1203 7 and and CC cord-024189-t7mbsr25 1203 8 indurated indurated JJ cord-024189-t7mbsr25 1203 9 , , , cord-024189-t7mbsr25 1203 10 followed follow VBN cord-024189-t7mbsr25 1203 11 by by IN cord-024189-t7mbsr25 1203 12 desquamation desquamation NN cord-024189-t7mbsr25 1203 13 in in IN cord-024189-t7mbsr25 1203 14 the the DT cord-024189-t7mbsr25 1203 15 skin skin NN cord-024189-t7mbsr25 1203 16 of of IN cord-024189-t7mbsr25 1203 17 these these DT cord-024189-t7mbsr25 1203 18 areas area NNS cord-024189-t7mbsr25 1203 19 during during IN cord-024189-t7mbsr25 1203 20 the the DT cord-024189-t7mbsr25 1203 21 healing healing NN cord-024189-t7mbsr25 1203 22 phase phase NN cord-024189-t7mbsr25 1203 23 ( ( -LRB- cord-024189-t7mbsr25 1203 24 7 7 CD cord-024189-t7mbsr25 1203 25 - - SYM cord-024189-t7mbsr25 1203 26 9 9 CD cord-024189-t7mbsr25 1203 27 ) ) -RRB- cord-024189-t7mbsr25 1203 28 . . . cord-024189-t7mbsr25 1204 1 The the DT cord-024189-t7mbsr25 1204 2 term term NN cord-024189-t7mbsr25 1204 3 atypical atypical JJ cord-024189-t7mbsr25 1204 4 KD KD NNP cord-024189-t7mbsr25 1204 5 has have VBZ cord-024189-t7mbsr25 1204 6 been be VBN cord-024189-t7mbsr25 1204 7 used use VBN cord-024189-t7mbsr25 1204 8 to to TO cord-024189-t7mbsr25 1204 9 describe describe VB cord-024189-t7mbsr25 1204 10 both both DT cord-024189-t7mbsr25 1204 11 older old JJR cord-024189-t7mbsr25 1204 12 children child NNS cord-024189-t7mbsr25 1204 13 and and CC cord-024189-t7mbsr25 1204 14 young young JJ cord-024189-t7mbsr25 1204 15 infants infant NNS cord-024189-t7mbsr25 1204 16 presenting present VBG cord-024189-t7mbsr25 1204 17 outside outside IN cord-024189-t7mbsr25 1204 18 the the DT cord-024189-t7mbsr25 1204 19 typical typical JJ cord-024189-t7mbsr25 1204 20 age age NN cord-024189-t7mbsr25 1204 21 range range NN cord-024189-t7mbsr25 1204 22 of of IN cord-024189-t7mbsr25 1204 23 2 2 CD cord-024189-t7mbsr25 1204 24 to to TO cord-024189-t7mbsr25 1204 25 5 5 CD cord-024189-t7mbsr25 1204 26 years year NNS cord-024189-t7mbsr25 1204 27 , , , cord-024189-t7mbsr25 1204 28 as as RB cord-024189-t7mbsr25 1204 29 well well RB cord-024189-t7mbsr25 1204 30 as as IN cord-024189-t7mbsr25 1204 31 those those DT cord-024189-t7mbsr25 1204 32 presenting present VBG cord-024189-t7mbsr25 1204 33 with with IN cord-024189-t7mbsr25 1204 34 features feature NNS cord-024189-t7mbsr25 1204 35 other other JJ cord-024189-t7mbsr25 1204 36 than than IN cord-024189-t7mbsr25 1204 37 the the DT cord-024189-t7mbsr25 1204 38 classical classical JJ cord-024189-t7mbsr25 1204 39 criteria criterion NNS cord-024189-t7mbsr25 1204 40 . . . cord-024189-t7mbsr25 1205 1 Incom- Incom- NNP cord-024189-t7mbsr25 1206 1 Coronary coronary JJ cord-024189-t7mbsr25 1206 2 and and CC cord-024189-t7mbsr25 1206 3 peripheral peripheral JJ cord-024189-t7mbsr25 1206 4 aneurysms aneurysm NNS cord-024189-t7mbsr25 1206 5 in in IN cord-024189-t7mbsr25 1206 6 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1206 7 's 's POS cord-024189-t7mbsr25 1206 8 disease disease NN cord-024189-t7mbsr25 1206 9 ( ( -LRB- cord-024189-t7mbsr25 1206 10 KD KD NNP cord-024189-t7mbsr25 1206 11 ) ) -RRB- cord-024189-t7mbsr25 1206 12 . . . cord-024189-t7mbsr25 1207 1 Magnetic magnetic JJ cord-024189-t7mbsr25 1207 2 resonance resonance NN cord-024189-t7mbsr25 1207 3 angiogram angiogram NN cord-024189-t7mbsr25 1207 4 in in IN cord-024189-t7mbsr25 1207 5 an an DT cord-024189-t7mbsr25 1207 6 infant infant NN cord-024189-t7mbsr25 1207 7 with with IN cord-024189-t7mbsr25 1207 8 KD KD NNP cord-024189-t7mbsr25 1207 9 , , , cord-024189-t7mbsr25 1207 10 revealing reveal VBG cord-024189-t7mbsr25 1207 11 irregularities irregularity NNS cord-024189-t7mbsr25 1207 12 of of IN cord-024189-t7mbsr25 1207 13 the the DT cord-024189-t7mbsr25 1207 14 subclavian subclavian JJ cord-024189-t7mbsr25 1207 15 , , , cord-024189-t7mbsr25 1207 16 axillary axillary JJ cord-024189-t7mbsr25 1207 17 , , , cord-024189-t7mbsr25 1207 18 and and CC cord-024189-t7mbsr25 1207 19 proximal proximal JJ cord-024189-t7mbsr25 1207 20 brachial brachial JJ cord-024189-t7mbsr25 1207 21 arteries artery NNS cord-024189-t7mbsr25 1207 22 , , , cord-024189-t7mbsr25 1207 23 as as RB cord-024189-t7mbsr25 1207 24 well well RB cord-024189-t7mbsr25 1207 25 as as IN cord-024189-t7mbsr25 1207 26 fusiform fusiform JJ cord-024189-t7mbsr25 1207 27 dilatation dilatation NN cord-024189-t7mbsr25 1207 28 of of IN cord-024189-t7mbsr25 1207 29 the the DT cord-024189-t7mbsr25 1207 30 right right JJ cord-024189-t7mbsr25 1207 31 common common JJ cord-024189-t7mbsr25 1207 32 iliac iliac NN cord-024189-t7mbsr25 1207 33 and and CC cord-024189-t7mbsr25 1207 34 right right JJ cord-024189-t7mbsr25 1207 35 proximal proximal JJ cord-024189-t7mbsr25 1207 36 internal internal JJ cord-024189-t7mbsr25 1207 37 iliac iliac JJ cord-024189-t7mbsr25 1207 38 arteries artery NNS cord-024189-t7mbsr25 1207 39 . . . cord-024189-t7mbsr25 1208 1 There there EX cord-024189-t7mbsr25 1208 2 is be VBZ cord-024189-t7mbsr25 1208 3 also also RB cord-024189-t7mbsr25 1208 4 a a DT cord-024189-t7mbsr25 1208 5 focal focal JJ cord-024189-t7mbsr25 1208 6 aneurysm aneurysm NN cord-024189-t7mbsr25 1208 7 of of IN cord-024189-t7mbsr25 1208 8 the the DT cord-024189-t7mbsr25 1208 9 left left JJ cord-024189-t7mbsr25 1208 10 internal internal JJ cord-024189-t7mbsr25 1208 11 iliac iliac JJ cord-024189-t7mbsr25 1208 12 artery artery NN cord-024189-t7mbsr25 1208 13 . . . cord-024189-t7mbsr25 1209 1 plete plete NNP cord-024189-t7mbsr25 1209 2 KD KD NNP cord-024189-t7mbsr25 1209 3 has have VBZ cord-024189-t7mbsr25 1209 4 been be VBN cord-024189-t7mbsr25 1209 5 applied apply VBN cord-024189-t7mbsr25 1209 6 to to IN cord-024189-t7mbsr25 1209 7 any any DT cord-024189-t7mbsr25 1209 8 patient patient NN cord-024189-t7mbsr25 1209 9 felt feel VBD cord-024189-t7mbsr25 1209 10 to to TO cord-024189-t7mbsr25 1209 11 have have VB cord-024189-t7mbsr25 1209 12 KD KD NNP cord-024189-t7mbsr25 1209 13 but but CC cord-024189-t7mbsr25 1209 14 who who WP cord-024189-t7mbsr25 1209 15 did do VBD cord-024189-t7mbsr25 1209 16 not not RB cord-024189-t7mbsr25 1209 17 fulfi fulfi NNP cord-024189-t7mbsr25 1209 18 ll will NNP cord-024189-t7mbsr25 1209 19 classical classical JJ cord-024189-t7mbsr25 1209 20 criteria criterion NNS cord-024189-t7mbsr25 1209 21 . . . cord-024189-t7mbsr25 1210 1 These these DT cord-024189-t7mbsr25 1210 2 are be VBP cord-024189-t7mbsr25 1210 3 often often RB cord-024189-t7mbsr25 1210 4 diagnosed diagnose VBN cord-024189-t7mbsr25 1210 5 by by IN cord-024189-t7mbsr25 1210 6 echocardiogram echocardiogram NN cord-024189-t7mbsr25 1210 7 fi fi NNP cord-024189-t7mbsr25 1210 8 ndings nding NNS cord-024189-t7mbsr25 1210 9 of of IN cord-024189-t7mbsr25 1210 10 coronary coronary JJ cord-024189-t7mbsr25 1210 11 aneurysms aneurysm NNS cord-024189-t7mbsr25 1210 12 and and CC cord-024189-t7mbsr25 1210 13 often often RB cord-024189-t7mbsr25 1210 14 occur occur VBP cord-024189-t7mbsr25 1210 15 in in IN cord-024189-t7mbsr25 1210 16 the the DT cord-024189-t7mbsr25 1210 17 older old JJR cord-024189-t7mbsr25 1210 18 children child NNS cord-024189-t7mbsr25 1210 19 or or CC cord-024189-t7mbsr25 1210 20 young young JJ cord-024189-t7mbsr25 1210 21 infants infant NNS cord-024189-t7mbsr25 1210 22 ( ( -LRB- cord-024189-t7mbsr25 1210 23 10 10 CD cord-024189-t7mbsr25 1210 24 , , , cord-024189-t7mbsr25 1210 25 11 11 CD cord-024189-t7mbsr25 1210 26 ) ) -RRB- cord-024189-t7mbsr25 1210 27 . . . cord-024189-t7mbsr25 1211 1 Coronary coronary JJ cord-024189-t7mbsr25 1211 2 aneurysms aneurysm NNS cord-024189-t7mbsr25 1211 3 , , , cord-024189-t7mbsr25 1211 4 in in IN cord-024189-t7mbsr25 1211 5 fact fact NN cord-024189-t7mbsr25 1211 6 , , , cord-024189-t7mbsr25 1211 7 are be VBP cord-024189-t7mbsr25 1211 8 most most RBS cord-024189-t7mbsr25 1211 9 likely likely JJ cord-024189-t7mbsr25 1211 10 to to TO cord-024189-t7mbsr25 1211 11 occur occur VB cord-024189-t7mbsr25 1211 12 in in IN cord-024189-t7mbsr25 1211 13 infants infant NNS cord-024189-t7mbsr25 1211 14 < < XX cord-024189-t7mbsr25 1211 15 6 6 CD cord-024189-t7mbsr25 1211 16 months month NNS cord-024189-t7mbsr25 1211 17 of of IN cord-024189-t7mbsr25 1211 18 age age NN cord-024189-t7mbsr25 1211 19 . . . cord-024189-t7mbsr25 1212 1 Because because IN cord-024189-t7mbsr25 1212 2 _SP cord-024189-t7mbsr25 1212 3 The the DT cord-024189-t7mbsr25 1212 4 epidemiology epidemiology NN cord-024189-t7mbsr25 1212 5 of of IN cord-024189-t7mbsr25 1212 6 KD KD NNP cord-024189-t7mbsr25 1212 7 is be VBZ cord-024189-t7mbsr25 1212 8 consistent consistent JJ cord-024189-t7mbsr25 1212 9 with with IN cord-024189-t7mbsr25 1212 10 an an DT cord-024189-t7mbsr25 1212 11 infectious infectious JJ cord-024189-t7mbsr25 1212 12 cause cause NN cord-024189-t7mbsr25 1212 13 : : : cord-024189-t7mbsr25 1212 14 clinical clinical JJ cord-024189-t7mbsr25 1212 15 features feature NNS cord-024189-t7mbsr25 1212 16 that that WDT cord-024189-t7mbsr25 1212 17 resemble resemble VBP cord-024189-t7mbsr25 1212 18 infection infection NN cord-024189-t7mbsr25 1212 19 ( ( -LRB- cord-024189-t7mbsr25 1212 20 fever fever NN cord-024189-t7mbsr25 1212 21 , , , cord-024189-t7mbsr25 1212 22 lymphadenopathy lymphadenopathy JJ cord-024189-t7mbsr25 1212 23 ) ) -RRB- cord-024189-t7mbsr25 1212 24 , , , cord-024189-t7mbsr25 1212 25 time time NN cord-024189-t7mbsr25 1212 26 / / SYM cord-024189-t7mbsr25 1212 27 space space NN cord-024189-t7mbsr25 1212 28 clusters cluster NNS cord-024189-t7mbsr25 1212 29 , , , cord-024189-t7mbsr25 1212 30 epidemic epidemic NN cord-024189-t7mbsr25 1212 31 occurrences occurrence NNS cord-024189-t7mbsr25 1212 32 , , , cord-024189-t7mbsr25 1212 33 and and CC cord-024189-t7mbsr25 1212 34 alleged alleged JJ cord-024189-t7mbsr25 1212 35 proximity proximity NN cord-024189-t7mbsr25 1212 36 of of IN cord-024189-t7mbsr25 1212 37 case case NN cord-024189-t7mbsr25 1212 38 foci foci NN cord-024189-t7mbsr25 1212 39 to to IN cord-024189-t7mbsr25 1212 40 bodies body NNS cord-024189-t7mbsr25 1212 41 of of IN cord-024189-t7mbsr25 1212 42 water water NN cord-024189-t7mbsr25 1212 43 . . . cord-024189-t7mbsr25 1213 1 To to IN cord-024189-t7mbsr25 1213 2 date date NN cord-024189-t7mbsr25 1213 3 , , , cord-024189-t7mbsr25 1213 4 however however RB cord-024189-t7mbsr25 1213 5 , , , cord-024189-t7mbsr25 1213 6 no no DT cord-024189-t7mbsr25 1213 7 infectious infectious JJ cord-024189-t7mbsr25 1213 8 etiology etiology NN cord-024189-t7mbsr25 1213 9 has have VBZ cord-024189-t7mbsr25 1213 10 been be VBN cord-024189-t7mbsr25 1213 11 proven prove VBN cord-024189-t7mbsr25 1213 12 . . . cord-024189-t7mbsr25 1214 1 There there EX cord-024189-t7mbsr25 1214 2 has have VBZ cord-024189-t7mbsr25 1214 3 been be VBN cord-024189-t7mbsr25 1214 4 no no DT cord-024189-t7mbsr25 1214 5 culture culture NN cord-024189-t7mbsr25 1214 6 or or CC cord-024189-t7mbsr25 1214 7 serologic serologic JJ cord-024189-t7mbsr25 1214 8 evidence evidence NN cord-024189-t7mbsr25 1214 9 for for IN cord-024189-t7mbsr25 1214 10 conventional conventional JJ cord-024189-t7mbsr25 1214 11 viral viral JJ cord-024189-t7mbsr25 1214 12 agents agent NNS cord-024189-t7mbsr25 1214 13 , , , cord-024189-t7mbsr25 1214 14 Mycoplasmae Mycoplasmae NNP cord-024189-t7mbsr25 1214 15 , , , cord-024189-t7mbsr25 1214 16 Rickettsiae Rickettsiae NNP cord-024189-t7mbsr25 1214 17 , , , cord-024189-t7mbsr25 1214 18 or or CC cord-024189-t7mbsr25 1214 19 bacterial bacterial JJ cord-024189-t7mbsr25 1214 20 agents agent NNS cord-024189-t7mbsr25 1214 21 ( ( -LRB- cord-024189-t7mbsr25 1214 22 Streptococcus Streptococcus NNP cord-024189-t7mbsr25 1214 23 , , , cord-024189-t7mbsr25 1214 24 Staphylococcus Staphylococcus NNP cord-024189-t7mbsr25 1214 25 ) ) -RRB- cord-024189-t7mbsr25 1214 26 . . . cord-024189-t7mbsr25 1215 1 Molecular molecular JJ cord-024189-t7mbsr25 1215 2 biologic biologic JJ cord-024189-t7mbsr25 1215 3 techniques technique NNS cord-024189-t7mbsr25 1215 4 have have VBP cord-024189-t7mbsr25 1215 5 provided provide VBN cord-024189-t7mbsr25 1215 6 support support NN cord-024189-t7mbsr25 1215 7 , , , cord-024189-t7mbsr25 1215 8 however however RB cord-024189-t7mbsr25 1215 9 , , , cord-024189-t7mbsr25 1215 10 for for IN cord-024189-t7mbsr25 1215 11 a a DT cord-024189-t7mbsr25 1215 12 Propionibacterium Propionibacterium NNP cord-024189-t7mbsr25 1215 13 acnes acnes NN cord-024189-t7mbsr25 1215 14 variant variant NN cord-024189-t7mbsr25 1215 15 , , , cord-024189-t7mbsr25 1215 16 retroviruses retrovirus NNS cord-024189-t7mbsr25 1215 17 , , , cord-024189-t7mbsr25 1215 18 Rickettsiae Rickettsiae NNP cord-024189-t7mbsr25 1215 19 , , , cord-024189-t7mbsr25 1215 20 parvovirus parvovirus NN cord-024189-t7mbsr25 1215 21 B19 B19 NNP cord-024189-t7mbsr25 1215 22 , , , cord-024189-t7mbsr25 1215 23 Epstein Epstein NNP cord-024189-t7mbsr25 1215 24 - - HYPH cord-024189-t7mbsr25 1215 25 Barr Barr NNP cord-024189-t7mbsr25 1215 26 virus virus NN cord-024189-t7mbsr25 1215 27 , , , cord-024189-t7mbsr25 1215 28 and and CC cord-024189-t7mbsr25 1215 29 coronavirus coronavirus NN cord-024189-t7mbsr25 1215 30 , , , cord-024189-t7mbsr25 1215 31 as as RB cord-024189-t7mbsr25 1215 32 well well RB cord-024189-t7mbsr25 1215 33 as as IN cord-024189-t7mbsr25 1215 34 for for IN cord-024189-t7mbsr25 1215 35 the the DT cord-024189-t7mbsr25 1215 36 participation participation NN cord-024189-t7mbsr25 1215 37 of of IN cord-024189-t7mbsr25 1215 38 the the DT cord-024189-t7mbsr25 1215 39 S. S. NNP cord-024189-t7mbsr25 1215 40 aureus aureus NN cord-024189-t7mbsr25 1215 41 toxin toxin NN cord-024189-t7mbsr25 1215 42 TSST-1 TSST-1 NNS cord-024189-t7mbsr25 1215 43 and and CC cord-024189-t7mbsr25 1215 44 other other JJ cord-024189-t7mbsr25 1215 45 superantigens superantigen NNS cord-024189-t7mbsr25 1215 46 ( ( -LRB- cord-024189-t7mbsr25 1215 47 e.g. e.g. RB cord-024189-t7mbsr25 1215 48 , , , cord-024189-t7mbsr25 1215 49 Yersinia Yersinia NNP cord-024189-t7mbsr25 1215 50 pseudotuberulosis pseudotuberulosis NN cord-024189-t7mbsr25 1215 51 ) ) -RRB- cord-024189-t7mbsr25 1215 52 . . . cord-024189-t7mbsr25 1216 1 Support support NN cord-024189-t7mbsr25 1216 2 exists exist VBZ cord-024189-t7mbsr25 1216 3 for for IN cord-024189-t7mbsr25 1216 4 a a DT cord-024189-t7mbsr25 1216 5 superantigen superantigen NN cord-024189-t7mbsr25 1216 6 - - HYPH cord-024189-t7mbsr25 1216 7 mediated mediate VBN cord-024189-t7mbsr25 1216 8 process process NN cord-024189-t7mbsr25 1216 9 both both CC cord-024189-t7mbsr25 1216 10 from from IN cord-024189-t7mbsr25 1216 11 clinical clinical JJ cord-024189-t7mbsr25 1216 12 studies study NNS cord-024189-t7mbsr25 1216 13 ( ( -LRB- cord-024189-t7mbsr25 1216 14 18 18 CD cord-024189-t7mbsr25 1216 15 ) ) -RRB- cord-024189-t7mbsr25 1216 16 ( ( -LRB- cord-024189-t7mbsr25 1216 17 19 19 CD cord-024189-t7mbsr25 1216 18 ) ) -RRB- cord-024189-t7mbsr25 1216 19 ( ( -LRB- cord-024189-t7mbsr25 1216 20 20 20 CD cord-024189-t7mbsr25 1216 21 ) ) -RRB- cord-024189-t7mbsr25 1216 22 ( ( -LRB- cord-024189-t7mbsr25 1216 23 21 21 CD cord-024189-t7mbsr25 1216 24 ) ) -RRB- cord-024189-t7mbsr25 1216 25 ( ( -LRB- cord-024189-t7mbsr25 1216 26 22 22 CD cord-024189-t7mbsr25 1216 27 ) ) -RRB- cord-024189-t7mbsr25 1216 28 and and CC cord-024189-t7mbsr25 1216 29 from from IN cord-024189-t7mbsr25 1216 30 a a DT cord-024189-t7mbsr25 1216 31 murine murine JJ cord-024189-t7mbsr25 1216 32 model model NN cord-024189-t7mbsr25 1216 33 for for IN cord-024189-t7mbsr25 1216 34 coronary coronary JJ cord-024189-t7mbsr25 1216 35 arteritis arteritis NN cord-024189-t7mbsr25 1216 36 stimulated stimulate VBN cord-024189-t7mbsr25 1216 37 by by IN cord-024189-t7mbsr25 1216 38 Lactobacillus Lactobacillus NNP cord-024189-t7mbsr25 1216 39 casei casei NN cord-024189-t7mbsr25 1216 40 cell cell NN cord-024189-t7mbsr25 1216 41 wall wall NN cord-024189-t7mbsr25 1216 42 extracts extract NNS cord-024189-t7mbsr25 1216 43 ( ( -LRB- cord-024189-t7mbsr25 1216 44 23 23 CD cord-024189-t7mbsr25 1216 45 ) ) -RRB- cord-024189-t7mbsr25 1216 46 . . . cord-024189-t7mbsr25 1217 1 This this DT cord-024189-t7mbsr25 1217 2 hypothesis hypothesis NN cord-024189-t7mbsr25 1217 3 proposes propose VBZ cord-024189-t7mbsr25 1217 4 that that IN cord-024189-t7mbsr25 1217 5 the the DT cord-024189-t7mbsr25 1217 6 etiologic etiologic JJ cord-024189-t7mbsr25 1217 7 agents agent NNS cord-024189-t7mbsr25 1217 8 - - : cord-024189-t7mbsr25 1217 9 which which WDT cord-024189-t7mbsr25 1217 10 may may MD cord-024189-t7mbsr25 1217 11 differ differ VB cord-024189-t7mbsr25 1217 12 across across IN cord-024189-t7mbsr25 1217 13 geographic geographic JJ cord-024189-t7mbsr25 1217 14 sites site NNS cord-024189-t7mbsr25 1217 15 throughout throughout IN cord-024189-t7mbsr25 1217 16 the the DT cord-024189-t7mbsr25 1217 17 world world NN cord-024189-t7mbsr25 1217 18 - - , cord-024189-t7mbsr25 1217 19 are be VBP cord-024189-t7mbsr25 1217 20 capable capable JJ cord-024189-t7mbsr25 1217 21 of of IN cord-024189-t7mbsr25 1217 22 evoking evoke VBG cord-024189-t7mbsr25 1217 23 immunologic immunologic JJ cord-024189-t7mbsr25 1217 24 responses response NNS cord-024189-t7mbsr25 1217 25 via via IN cord-024189-t7mbsr25 1217 26 T t NN cord-024189-t7mbsr25 1217 27 - - HYPH cord-024189-t7mbsr25 1217 28 cell cell NN cord-024189-t7mbsr25 1217 29 receptor receptor NN cord-024189-t7mbsr25 1217 30 V v NN cord-024189-t7mbsr25 1217 31 beta beta NN cord-024189-t7mbsr25 1217 32 restriction restriction NN cord-024189-t7mbsr25 1217 33 . . . cord-024189-t7mbsr25 1218 1 An an DT cord-024189-t7mbsr25 1218 2 oligoclonal oligoclonal JJ cord-024189-t7mbsr25 1218 3 response response NN cord-024189-t7mbsr25 1218 4 is be VBZ cord-024189-t7mbsr25 1218 5 supported support VBN cord-024189-t7mbsr25 1218 6 by by IN cord-024189-t7mbsr25 1218 7 the the DT cord-024189-t7mbsr25 1218 8 discovery discovery NN cord-024189-t7mbsr25 1218 9 of of IN cord-024189-t7mbsr25 1218 10 IgA IgA NNP cord-024189-t7mbsr25 1218 11 - - HYPH cord-024189-t7mbsr25 1218 12 secreting secrete VBG cord-024189-t7mbsr25 1218 13 plasma plasma NN cord-024189-t7mbsr25 1218 14 cells cell NNS cord-024189-t7mbsr25 1218 15 within within IN cord-024189-t7mbsr25 1218 16 gia gia NNP cord-024189-t7mbsr25 1218 17 and and CC cord-024189-t7mbsr25 1218 18 arthritis arthritis NN cord-024189-t7mbsr25 1218 19 , , , cord-024189-t7mbsr25 1218 20 aseptic aseptic JJ cord-024189-t7mbsr25 1218 21 meningitis meningitis NN cord-024189-t7mbsr25 1218 22 , , , cord-024189-t7mbsr25 1218 23 diarrhea diarrhea NN cord-024189-t7mbsr25 1218 24 , , , cord-024189-t7mbsr25 1218 25 abdominal abdominal JJ cord-024189-t7mbsr25 1218 26 pain pain NN cord-024189-t7mbsr25 1218 27 , , , cord-024189-t7mbsr25 1218 28 pericardial pericardial JJ cord-024189-t7mbsr25 1218 29 effusion effusion NN cord-024189-t7mbsr25 1218 30 , , , cord-024189-t7mbsr25 1218 31 obstructive obstructive JJ cord-024189-t7mbsr25 1218 32 jaundice jaundice NN cord-024189-t7mbsr25 1218 33 , , , cord-024189-t7mbsr25 1218 34 and and CC cord-024189-t7mbsr25 1218 35 hydrops hydrop NNS cord-024189-t7mbsr25 1218 36 of of IN cord-024189-t7mbsr25 1218 37 the the DT cord-024189-t7mbsr25 1218 38 gallbladder gallbladder NN cord-024189-t7mbsr25 1218 39 . . . cord-024189-t7mbsr25 1219 1 Intravenous intravenous JJ cord-024189-t7mbsr25 1219 2 immune immune JJ cord-024189-t7mbsr25 1219 3 globulin globulin NN cord-024189-t7mbsr25 1219 4 ( ( -LRB- cord-024189-t7mbsr25 1219 5 IVIG IVIG NNP cord-024189-t7mbsr25 1219 6 ) ) -RRB- cord-024189-t7mbsr25 1219 7 , , , cord-024189-t7mbsr25 1219 8 a a DT cord-024189-t7mbsr25 1219 9 critical critical JJ cord-024189-t7mbsr25 1219 10 medication medication NN cord-024189-t7mbsr25 1219 11 in in IN cord-024189-t7mbsr25 1219 12 the the DT cord-024189-t7mbsr25 1219 13 treatment treatment NN cord-024189-t7mbsr25 1219 14 of of IN cord-024189-t7mbsr25 1219 15 KD KD NNP cord-024189-t7mbsr25 1219 16 , , , cord-024189-t7mbsr25 1219 17 is be VBZ cord-024189-t7mbsr25 1219 18 a a DT cord-024189-t7mbsr25 1219 19 limited limited JJ cord-024189-t7mbsr25 1219 20 resource resource NN cord-024189-t7mbsr25 1219 21 in in IN cord-024189-t7mbsr25 1219 22 many many JJ cord-024189-t7mbsr25 1219 23 parts part NNS cord-024189-t7mbsr25 1219 24 of of IN cord-024189-t7mbsr25 1219 25 the the DT cord-024189-t7mbsr25 1219 26 world world NN cord-024189-t7mbsr25 1219 27 because because IN cord-024189-t7mbsr25 1219 28 of of IN cord-024189-t7mbsr25 1219 29 its -PRON- PRP$ cord-024189-t7mbsr25 1219 30 expense expense NN cord-024189-t7mbsr25 1219 31 . . . cord-024189-t7mbsr25 1220 1 The the DT cord-024189-t7mbsr25 1220 2 American American NNP cord-024189-t7mbsr25 1220 3 Heart Heart NNP cord-024189-t7mbsr25 1220 4 Association Association NNP cord-024189-t7mbsr25 1220 5 ( ( -LRB- cord-024189-t7mbsr25 1220 6 AHA AHA NNP cord-024189-t7mbsr25 1220 7 ) ) -RRB- cord-024189-t7mbsr25 1220 8 , , , cord-024189-t7mbsr25 1220 9 concerned concern VBN cord-024189-t7mbsr25 1220 10 about about IN cord-024189-t7mbsr25 1220 11 both both CC cord-024189-t7mbsr25 1220 12 the the DT cord-024189-t7mbsr25 1220 13 potential potential NN cord-024189-t7mbsr25 1220 14 for for IN cord-024189-t7mbsr25 1220 15 overuse overuse NN cord-024189-t7mbsr25 1220 16 of of IN cord-024189-t7mbsr25 1220 17 IVIG IVIG NNP cord-024189-t7mbsr25 1220 18 as as RB cord-024189-t7mbsr25 1220 19 well well RB cord-024189-t7mbsr25 1220 20 as as IN cord-024189-t7mbsr25 1220 21 the the DT cord-024189-t7mbsr25 1220 22 failure failure NN cord-024189-t7mbsr25 1220 23 to to TO cord-024189-t7mbsr25 1220 24 employ employ VB cord-024189-t7mbsr25 1220 25 this this DT cord-024189-t7mbsr25 1220 26 medication medication NN cord-024189-t7mbsr25 1220 27 in in IN cord-024189-t7mbsr25 1220 28 a a DT cord-024189-t7mbsr25 1220 29 timely timely JJ cord-024189-t7mbsr25 1220 30 manner manner NN cord-024189-t7mbsr25 1220 31 in in IN cord-024189-t7mbsr25 1220 32 appropriate appropriate JJ cord-024189-t7mbsr25 1220 33 patients patient NNS cord-024189-t7mbsr25 1220 34 , , , cord-024189-t7mbsr25 1220 35 issued issue VBD cord-024189-t7mbsr25 1220 36 guidelines guideline NNS cord-024189-t7mbsr25 1220 37 on on IN cord-024189-t7mbsr25 1220 38 the the DT cord-024189-t7mbsr25 1220 39 diagnosis diagnosis NN cord-024189-t7mbsr25 1220 40 and and CC cord-024189-t7mbsr25 1220 41 treatment treatment NN cord-024189-t7mbsr25 1220 42 of of IN cord-024189-t7mbsr25 1220 43 KD KD NNP cord-024189-t7mbsr25 1220 44 ( ( -LRB- cord-024189-t7mbsr25 1220 45 Tables table NNS cord-024189-t7mbsr25 1220 46 21F-2 21f-2 CD cord-024189-t7mbsr25 1220 47 through through IN cord-024189-t7mbsr25 1220 48 21F-4 21f-4 CD cord-024189-t7mbsr25 1220 49 ) ) -RRB- cord-024189-t7mbsr25 1220 50 ( ( -LRB- cord-024189-t7mbsr25 1220 51 12 12 CD cord-024189-t7mbsr25 1220 52 , , , cord-024189-t7mbsr25 1220 53 13 13 CD cord-024189-t7mbsr25 1220 54 ) ) -RRB- cord-024189-t7mbsr25 1220 55 . . . cord-024189-t7mbsr25 1221 1 In in IN cord-024189-t7mbsr25 1221 2 these these DT cord-024189-t7mbsr25 1221 3 guidelines guideline NNS cord-024189-t7mbsr25 1221 4 , , , cord-024189-t7mbsr25 1221 5 the the DT cord-024189-t7mbsr25 1221 6 epidemiologic epidemiologic JJ cord-024189-t7mbsr25 1221 7 case case NN cord-024189-t7mbsr25 1221 8 defi defi NNP cord-024189-t7mbsr25 1221 9 nition nition NN cord-024189-t7mbsr25 1221 10 of of IN cord-024189-t7mbsr25 1221 11 KD KD NNP cord-024189-t7mbsr25 1221 12 included include VBD cord-024189-t7mbsr25 1221 13 fever fever NN cord-024189-t7mbsr25 1221 14 of of IN cord-024189-t7mbsr25 1221 15 at at RB cord-024189-t7mbsr25 1221 16 least least JJS cord-024189-t7mbsr25 1221 17 4 4 CD cord-024189-t7mbsr25 1221 18 days day NNS cord-024189-t7mbsr25 1221 19 and and CC cord-024189-t7mbsr25 1221 20 four four CD cord-024189-t7mbsr25 1221 21 or or CC cord-024189-t7mbsr25 1221 22 more more JJR cord-024189-t7mbsr25 1221 23 principal principal JJ cord-024189-t7mbsr25 1221 24 criteria criterion NNS cord-024189-t7mbsr25 1221 25 ( ( -LRB- cord-024189-t7mbsr25 1221 26 Table table NN cord-024189-t7mbsr25 1221 27 _SP cord-024189-t7mbsr25 1221 28 21F 21f NN cord-024189-t7mbsr25 1221 29 -1 -1 NN cord-024189-t7mbsr25 1221 30 ) ) -RRB- cord-024189-t7mbsr25 1221 31 without without IN cord-024189-t7mbsr25 1221 32 other other JJ cord-024189-t7mbsr25 1221 33 explanation explanation NN cord-024189-t7mbsr25 1221 34 ; ; : cord-024189-t7mbsr25 1221 35 or or CC cord-024189-t7mbsr25 1221 36 fever fever NN cord-024189-t7mbsr25 1221 37 and and CC cord-024189-t7mbsr25 1221 38 less less JJR cord-024189-t7mbsr25 1221 39 than than IN cord-024189-t7mbsr25 1221 40 four four CD cord-024189-t7mbsr25 1221 41 principal principal JJ cord-024189-t7mbsr25 1221 42 criteria criterion NNS cord-024189-t7mbsr25 1221 43 if if IN cord-024189-t7mbsr25 1221 44 coronary coronary JJ cord-024189-t7mbsr25 1221 45 artery artery NN cord-024189-t7mbsr25 1221 46 abnormalities abnormality NNS cord-024189-t7mbsr25 1221 47 are be VBP cord-024189-t7mbsr25 1221 48 detected detect VBN cord-024189-t7mbsr25 1221 49 by by IN cord-024189-t7mbsr25 1221 50 echocardiogram echocardiogram NN cord-024189-t7mbsr25 1221 51 or or CC cord-024189-t7mbsr25 1221 52 coronary coronary JJ cord-024189-t7mbsr25 1221 53 angiography angiography NN cord-024189-t7mbsr25 1221 54 . . . cord-024189-t7mbsr25 1222 1 In in IN cord-024189-t7mbsr25 1222 2 Japan Japan NNP cord-024189-t7mbsr25 1222 3 , , , cord-024189-t7mbsr25 1222 4 the the DT cord-024189-t7mbsr25 1222 5 illness illness NN cord-024189-t7mbsr25 1222 6 appears appear VBZ cord-024189-t7mbsr25 1222 7 in in IN cord-024189-t7mbsr25 1222 8 late late JJ cord-024189-t7mbsr25 1222 9 winter winter NN cord-024189-t7mbsr25 1222 10 and and CC cord-024189-t7mbsr25 1222 11 spring spring NN cord-024189-t7mbsr25 1222 12 . . . cord-024189-t7mbsr25 1223 1 The the DT cord-024189-t7mbsr25 1223 2 peak peak NN cord-024189-t7mbsr25 1223 3 age age NN cord-024189-t7mbsr25 1223 4 is be VBZ cord-024189-t7mbsr25 1223 5 6 6 CD cord-024189-t7mbsr25 1223 6 to to TO cord-024189-t7mbsr25 1223 7 12 12 CD cord-024189-t7mbsr25 1223 8 months month NNS cord-024189-t7mbsr25 1223 9 , , , cord-024189-t7mbsr25 1223 10 with with IN cord-024189-t7mbsr25 1223 11 80 80 CD cord-024189-t7mbsr25 1223 12 % % NN cord-024189-t7mbsr25 1223 13 of of IN cord-024189-t7mbsr25 1223 14 cases case NNS cord-024189-t7mbsr25 1223 15 occurring occur VBG cord-024189-t7mbsr25 1223 16 in in IN cord-024189-t7mbsr25 1223 17 patients patient NNS cord-024189-t7mbsr25 1223 18 younger young JJR cord-024189-t7mbsr25 1223 19 than than IN cord-024189-t7mbsr25 1223 20 5 5 CD cord-024189-t7mbsr25 1223 21 years year NNS cord-024189-t7mbsr25 1223 22 of of IN cord-024189-t7mbsr25 1223 23 age age NN cord-024189-t7mbsr25 1223 24 . . . cord-024189-t7mbsr25 1224 1 The the DT cord-024189-t7mbsr25 1224 2 male male JJ cord-024189-t7mbsr25 1224 3 : : : cord-024189-t7mbsr25 1224 4 female female JJ cord-024189-t7mbsr25 1224 5 ratio ratio NN cord-024189-t7mbsr25 1224 6 is be VBZ cord-024189-t7mbsr25 1224 7 1.5:1 1.5:1 CD cord-024189-t7mbsr25 1224 8 . . . cord-024189-t7mbsr25 1225 1 Except except IN cord-024189-t7mbsr25 1225 2 for for IN cord-024189-t7mbsr25 1225 3 three three CD cord-024189-t7mbsr25 1225 4 major major JJ cord-024189-t7mbsr25 1225 5 pandemics pandemic NNS cord-024189-t7mbsr25 1225 6 ( ( -LRB- cord-024189-t7mbsr25 1225 7 1979 1979 CD cord-024189-t7mbsr25 1225 8 , , , cord-024189-t7mbsr25 1225 9 1982 1982 CD cord-024189-t7mbsr25 1225 10 , , , cord-024189-t7mbsr25 1225 11 1985/6 1985/6 CD cord-024189-t7mbsr25 1225 12 ) ) -RRB- cord-024189-t7mbsr25 1225 13 , , , cord-024189-t7mbsr25 1225 14 the the DT cord-024189-t7mbsr25 1225 15 cases case NNS cord-024189-t7mbsr25 1225 16 have have VBP cord-024189-t7mbsr25 1225 17 reached reach VBN cord-024189-t7mbsr25 1225 18 a a DT cord-024189-t7mbsr25 1225 19 plateau plateau NN cord-024189-t7mbsr25 1225 20 of of IN cord-024189-t7mbsr25 1225 21 5000 5000 CD cord-024189-t7mbsr25 1225 22 to to IN cord-024189-t7mbsr25 1225 23 6000 6000 CD cord-024189-t7mbsr25 1225 24 per per IN cord-024189-t7mbsr25 1225 25 year year NN cord-024189-t7mbsr25 1225 26 . . . cord-024189-t7mbsr25 1226 1 The the DT cord-024189-t7mbsr25 1226 2 endemic endemic JJ cord-024189-t7mbsr25 1226 3 annual annual JJ cord-024189-t7mbsr25 1226 4 incidence incidence NN cord-024189-t7mbsr25 1226 5 is be VBZ cord-024189-t7mbsr25 1226 6 67/100,000 67/100,000 CD cord-024189-t7mbsr25 1226 7 children child NNS cord-024189-t7mbsr25 1226 8 < < XX cord-024189-t7mbsr25 1226 9 5 5 CD cord-024189-t7mbsr25 1226 10 years year NNS cord-024189-t7mbsr25 1226 11 old old JJ cord-024189-t7mbsr25 1226 12 , , , cord-024189-t7mbsr25 1226 13 with with IN cord-024189-t7mbsr25 1226 14 a a DT cord-024189-t7mbsr25 1226 15 recurrence recurrence NN cord-024189-t7mbsr25 1226 16 rate rate NN cord-024189-t7mbsr25 1226 17 of of IN cord-024189-t7mbsr25 1226 18 6 6 CD cord-024189-t7mbsr25 1226 19 % % NN cord-024189-t7mbsr25 1226 20 . . . cord-024189-t7mbsr25 1227 1 In in IN cord-024189-t7mbsr25 1227 2 the the DT cord-024189-t7mbsr25 1227 3 United United NNP cord-024189-t7mbsr25 1227 4 States States NNP cord-024189-t7mbsr25 1227 5 , , , cord-024189-t7mbsr25 1227 6 there there EX cord-024189-t7mbsr25 1227 7 is be VBZ cord-024189-t7mbsr25 1227 8 also also RB cord-024189-t7mbsr25 1227 9 a a DT cord-024189-t7mbsr25 1227 10 seasonal seasonal JJ cord-024189-t7mbsr25 1227 11 variation variation NN cord-024189-t7mbsr25 1227 12 in in IN cord-024189-t7mbsr25 1227 13 most most JJS cord-024189-t7mbsr25 1227 14 places place NNS cord-024189-t7mbsr25 1227 15 . . . cord-024189-t7mbsr25 1228 1 The the DT cord-024189-t7mbsr25 1228 2 peak peak NN cord-024189-t7mbsr25 1228 3 age age NN cord-024189-t7mbsr25 1228 4 is be VBZ cord-024189-t7mbsr25 1228 5 18 18 CD cord-024189-t7mbsr25 1228 6 to to TO cord-024189-t7mbsr25 1228 7 24 24 CD cord-024189-t7mbsr25 1228 8 months month NNS cord-024189-t7mbsr25 1228 9 , , , cord-024189-t7mbsr25 1228 10 and and CC cord-024189-t7mbsr25 1228 11 the the DT cord-024189-t7mbsr25 1228 12 illness illness NN cord-024189-t7mbsr25 1228 13 accounts account VBZ cord-024189-t7mbsr25 1228 14 for for IN cord-024189-t7mbsr25 1228 15 3000 3000 CD cord-024189-t7mbsr25 1228 16 hospitalizations hospitalization NNS cord-024189-t7mbsr25 1228 17 / / SYM cord-024189-t7mbsr25 1228 18 year year NN cord-024189-t7mbsr25 1228 19 . . . cord-024189-t7mbsr25 1229 1 The the DT cord-024189-t7mbsr25 1229 2 recurrence recurrence NN cord-024189-t7mbsr25 1229 3 rate rate NN cord-024189-t7mbsr25 1229 4 is be VBZ cord-024189-t7mbsr25 1229 5 1 1 CD cord-024189-t7mbsr25 1229 6 % % NN cord-024189-t7mbsr25 1229 7 to to TO cord-024189-t7mbsr25 1229 8 3 3 CD cord-024189-t7mbsr25 1229 9 % % NN cord-024189-t7mbsr25 1229 10 . . . cord-024189-t7mbsr25 1230 1 Data datum NNS cord-024189-t7mbsr25 1230 2 from from IN cord-024189-t7mbsr25 1230 3 Hawaii Hawaii NNP cord-024189-t7mbsr25 1230 4 from from IN cord-024189-t7mbsr25 1230 5 1971 1971 CD cord-024189-t7mbsr25 1230 6 - - SYM cord-024189-t7mbsr25 1230 7 1980 1980 CD cord-024189-t7mbsr25 1230 8 show show VBP cord-024189-t7mbsr25 1230 9 ethnic ethnic JJ cord-024189-t7mbsr25 1230 10 incidence incidence NN cord-024189-t7mbsr25 1231 1 rate/100,000 rate/100,000 NNP cord-024189-t7mbsr25 1231 2 children child NNS cord-024189-t7mbsr25 1232 1 < < NNP cord-024189-t7mbsr25 1232 2 8 8 CD cord-024189-t7mbsr25 1232 3 years year NNS cord-024189-t7mbsr25 1232 4 old old JJ cord-024189-t7mbsr25 1232 5 per per IN cord-024189-t7mbsr25 1232 6 year year NN cord-024189-t7mbsr25 1232 7 of of IN cord-024189-t7mbsr25 1232 8 33.6 33.6 CD cord-024189-t7mbsr25 1232 9 in in IN cord-024189-t7mbsr25 1232 10 Japanese Japanese NNP cord-024189-t7mbsr25 1232 11 , , , cord-024189-t7mbsr25 1232 12 11.1 11.1 CD cord-024189-t7mbsr25 1232 13 in in IN cord-024189-t7mbsr25 1232 14 Chinese Chinese NNP cord-024189-t7mbsr25 1232 15 , , , cord-024189-t7mbsr25 1232 16 9.2 9.2 CD cord-024189-t7mbsr25 1232 17 in in IN cord-024189-t7mbsr25 1232 18 Hawaiians Hawaiians NNPS cord-024189-t7mbsr25 1232 19 , , , cord-024189-t7mbsr25 1232 20 2.9 2.9 CD cord-024189-t7mbsr25 1232 21 in in IN cord-024189-t7mbsr25 1232 22 Filipinos Filipinos NNPS cord-024189-t7mbsr25 1232 23 , , , cord-024189-t7mbsr25 1232 24 2.8 2.8 CD cord-024189-t7mbsr25 1232 25 in in IN cord-024189-t7mbsr25 1232 26 Caucasians Caucasians NNPS cord-024189-t7mbsr25 1232 27 . . . cord-024189-t7mbsr25 1233 1 In in IN cord-024189-t7mbsr25 1233 2 Los Los NNP cord-024189-t7mbsr25 1233 3 Angeles Angeles NNP cord-024189-t7mbsr25 1233 4 from from IN cord-024189-t7mbsr25 1233 5 1980 1980 CD cord-024189-t7mbsr25 1233 6 - - SYM cord-024189-t7mbsr25 1233 7 1983 1983 CD cord-024189-t7mbsr25 1233 8 , , , cord-024189-t7mbsr25 1233 9 rates rate NNS cord-024189-t7mbsr25 1233 10 per per IN cord-024189-t7mbsr25 1233 11 100,000 100,000 CD cord-024189-t7mbsr25 1233 12 children child NNS cord-024189-t7mbsr25 1233 13 the the DT cord-024189-t7mbsr25 1233 14 walls wall NNS cord-024189-t7mbsr25 1233 15 of of IN cord-024189-t7mbsr25 1233 16 the the DT cord-024189-t7mbsr25 1233 17 affected affect VBN cord-024189-t7mbsr25 1233 18 arteries artery NNS cord-024189-t7mbsr25 1233 19 . . . cord-024189-t7mbsr25 1234 1 This this DT cord-024189-t7mbsr25 1234 2 fi fi NN cord-024189-t7mbsr25 1234 3 nding nding NN cord-024189-t7mbsr25 1234 4 lends lend VBZ cord-024189-t7mbsr25 1234 5 credence credence NN cord-024189-t7mbsr25 1234 6 to to IN cord-024189-t7mbsr25 1234 7 the the DT cord-024189-t7mbsr25 1234 8 hypothesis hypothesis NN cord-024189-t7mbsr25 1234 9 that that IN cord-024189-t7mbsr25 1234 10 the the DT cord-024189-t7mbsr25 1234 11 respiratory respiratory JJ cord-024189-t7mbsr25 1234 12 or or CC cord-024189-t7mbsr25 1234 13 gastrointestinal gastrointestinal JJ cord-024189-t7mbsr25 1234 14 tract tract NN cord-024189-t7mbsr25 1234 15 may may MD cord-024189-t7mbsr25 1234 16 be be VB cord-024189-t7mbsr25 1234 17 the the DT cord-024189-t7mbsr25 1234 18 portal portal NN cord-024189-t7mbsr25 1234 19 of of IN cord-024189-t7mbsr25 1234 20 entry entry NN cord-024189-t7mbsr25 1234 21 for for IN cord-024189-t7mbsr25 1234 22 the the DT cord-024189-t7mbsr25 1234 23 inciting incite VBG cord-024189-t7mbsr25 1234 24 organism organism NN cord-024189-t7mbsr25 1234 25 , , , cord-024189-t7mbsr25 1234 26 and and CC cord-024189-t7mbsr25 1234 27 that that IN cord-024189-t7mbsr25 1234 28 the the DT cord-024189-t7mbsr25 1234 29 process process NN cord-024189-t7mbsr25 1234 30 is be VBZ cord-024189-t7mbsr25 1234 31 antigen antigen NN cord-024189-t7mbsr25 1234 32 - - HYPH cord-024189-t7mbsr25 1234 33 driven drive VBN cord-024189-t7mbsr25 1234 34 ( ( -LRB- cord-024189-t7mbsr25 1234 35 24 24 CD cord-024189-t7mbsr25 1234 36 , , , cord-024189-t7mbsr25 1234 37 25 25 CD cord-024189-t7mbsr25 1234 38 ) ) -RRB- cord-024189-t7mbsr25 1234 39 . . . cord-024189-t7mbsr25 1235 1 The the DT cord-024189-t7mbsr25 1235 2 pathogenesis pathogenesis NN cord-024189-t7mbsr25 1235 3 is be VBZ cord-024189-t7mbsr25 1235 4 characterized characterize VBN cord-024189-t7mbsr25 1235 5 by by IN cord-024189-t7mbsr25 1235 6 immune immune JJ cord-024189-t7mbsr25 1235 7 activation activation NN cord-024189-t7mbsr25 1235 8 . . . cord-024189-t7mbsr25 1236 1 A a DT cord-024189-t7mbsr25 1236 2 host host NN cord-024189-t7mbsr25 1236 3 of of IN cord-024189-t7mbsr25 1236 4 immunologic immunologic JJ cord-024189-t7mbsr25 1236 5 irregularities irregularity NNS cord-024189-t7mbsr25 1236 6 have have VBP cord-024189-t7mbsr25 1236 7 been be VBN cord-024189-t7mbsr25 1236 8 described describe VBN cord-024189-t7mbsr25 1236 9 in in IN cord-024189-t7mbsr25 1236 10 KD KD NNP cord-024189-t7mbsr25 1236 11 , , , cord-024189-t7mbsr25 1237 1 not not RB cord-024189-t7mbsr25 1237 2 all all DT cord-024189-t7mbsr25 1237 3 of of IN cord-024189-t7mbsr25 1237 4 which which WDT cord-024189-t7mbsr25 1237 5 have have VBP cord-024189-t7mbsr25 1237 6 been be VBN cord-024189-t7mbsr25 1237 7 confi confi VBN cord-024189-t7mbsr25 1237 8 rmed rme VBN cord-024189-t7mbsr25 1237 9 consistently consistently RB cord-024189-t7mbsr25 1237 10 : : : cord-024189-t7mbsr25 1237 11 endothelial endothelial JJ cord-024189-t7mbsr25 1237 12 cell cell NN cord-024189-t7mbsr25 1237 13 activation activation NN cord-024189-t7mbsr25 1237 14 [ [ -LRB- cord-024189-t7mbsr25 1237 15 particularly particularly RB cord-024189-t7mbsr25 1237 16 human human JJ cord-024189-t7mbsr25 1237 17 leukocyte leukocyte NN cord-024189-t7mbsr25 1237 18 antigen antigen NN cord-024189-t7mbsr25 1237 19 ( ( -LRB- cord-024189-t7mbsr25 1237 20 HLA)-DR hla)-dr CD cord-024189-t7mbsr25 1237 21 expression expression NN cord-024189-t7mbsr25 1237 22 on on IN cord-024189-t7mbsr25 1237 23 coronary coronary JJ cord-024189-t7mbsr25 1237 24 endothelial endothelial JJ cord-024189-t7mbsr25 1237 25 cells cell NNS cord-024189-t7mbsr25 1237 26 ] ] -RRB- cord-024189-t7mbsr25 1237 27 ; ; : cord-024189-t7mbsr25 1237 28 autoantibody autoantibody NNP cord-024189-t7mbsr25 1237 29 formation formation NN cord-024189-t7mbsr25 1237 30 ( ( -LRB- cord-024189-t7mbsr25 1237 31 e.g. e.g. RB cord-024189-t7mbsr25 1237 32 , , , cord-024189-t7mbsr25 1237 33 anti anti JJ cord-024189-t7mbsr25 1237 34 - - JJ cord-024189-t7mbsr25 1237 35 endothelial endothelial JJ cord-024189-t7mbsr25 1237 36 cell cell NN cord-024189-t7mbsr25 1237 37 antibodies antibody NNS cord-024189-t7mbsr25 1237 38 ) ) -RRB- cord-024189-t7mbsr25 1237 39 ; ; : cord-024189-t7mbsr25 1237 40 complement complement JJ cord-024189-t7mbsr25 1237 41 activation activation NN cord-024189-t7mbsr25 1237 42 and and CC cord-024189-t7mbsr25 1237 43 immune immune JJ cord-024189-t7mbsr25 1237 44 complex complex JJ cord-024189-t7mbsr25 1237 45 formation formation NN cord-024189-t7mbsr25 1237 46 ; ; : cord-024189-t7mbsr25 1237 47 abnormalities abnormality NNS cord-024189-t7mbsr25 1237 48 of of IN cord-024189-t7mbsr25 1237 49 immunoregulation immunoregulation NN cord-024189-t7mbsr25 1237 50 ( ( -LRB- cord-024189-t7mbsr25 1237 51 lymphocyte lymphocyte NNP cord-024189-t7mbsr25 1237 52 infi infi NNP cord-024189-t7mbsr25 1237 53 ltration ltration NNP cord-024189-t7mbsr25 1237 54 , , , cord-024189-t7mbsr25 1237 55 activated activate VBD cord-024189-t7mbsr25 1237 56 CD4 CD4 NNP cord-024189-t7mbsr25 1237 57 + + CC cord-024189-t7mbsr25 1237 58 and and CC cord-024189-t7mbsr25 1237 59 B b NN cord-024189-t7mbsr25 1237 60 cells cell NNS cord-024189-t7mbsr25 1237 61 , , , cord-024189-t7mbsr25 1237 62 activated activate VBN cord-024189-t7mbsr25 1237 63 monocyte monocyte NNP cord-024189-t7mbsr25 1237 64 / / SYM cord-024189-t7mbsr25 1237 65 macrophages macrophage NNS cord-024189-t7mbsr25 1237 66 , , , cord-024189-t7mbsr25 1237 67 T T NNP cord-024189-t7mbsr25 1237 68 lymphopenia lymphopenia NNP cord-024189-t7mbsr25 1237 69 , , , cord-024189-t7mbsr25 1237 70 polyclonal polyclonal JJ cord-024189-t7mbsr25 1237 71 B b NN cord-024189-t7mbsr25 1237 72 - - HYPH cord-024189-t7mbsr25 1237 73 cell cell NN cord-024189-t7mbsr25 1237 74 activation activation NN cord-024189-t7mbsr25 1237 75 ) ) -RRB- cord-024189-t7mbsr25 1237 76 ; ; : cord-024189-t7mbsr25 1237 77 adhesion adhesion NN cord-024189-t7mbsr25 1237 78 molecule molecule NN cord-024189-t7mbsr25 1237 79 upregulation upregulation NN cord-024189-t7mbsr25 1237 80 ( ( -LRB- cord-024189-t7mbsr25 1237 81 soluble soluble NNP cord-024189-t7mbsr25 1237 82 P- P- NNP cord-024189-t7mbsr25 1237 83 , , , cord-024189-t7mbsr25 1237 84 E- E- NNP cord-024189-t7mbsr25 1237 85 , , , cord-024189-t7mbsr25 1237 86 and and CC cord-024189-t7mbsr25 1237 87 L l NN cord-024189-t7mbsr25 1237 88 - - HYPH cord-024189-t7mbsr25 1237 89 selectins selectins NNP cord-024189-t7mbsr25 1237 90 ) ) -RRB- cord-024189-t7mbsr25 1237 91 ; ; , cord-024189-t7mbsr25 1237 92 increased increase VBN cord-024189-t7mbsr25 1237 93 vascular vascular JJ cord-024189-t7mbsr25 1237 94 endothelial endothelial JJ cord-024189-t7mbsr25 1237 95 growth growth NN cord-024189-t7mbsr25 1237 96 factor factor NN cord-024189-t7mbsr25 1237 97 ; ; : cord-024189-t7mbsr25 1237 98 and and CC cord-024189-t7mbsr25 1237 99 marked mark VBN cord-024189-t7mbsr25 1237 100 cytokine cytokine NN cord-024189-t7mbsr25 1237 101 production production NN cord-024189-t7mbsr25 1237 102 with with IN cord-024189-t7mbsr25 1237 103 high high JJ cord-024189-t7mbsr25 1237 104 levels level NNS cord-024189-t7mbsr25 1237 105 of of IN cord-024189-t7mbsr25 1237 106 interferon interferon NN cord-024189-t7mbsr25 1237 107 - - HYPH cord-024189-t7mbsr25 1237 108 gamma gamma NN cord-024189-t7mbsr25 1237 109 , , , cord-024189-t7mbsr25 1237 110 interleukins-1 interleukins-1 NNP cord-024189-t7mbsr25 1237 111 , , , cord-024189-t7mbsr25 1237 112 -4 -4 NNP cord-024189-t7mbsr25 1237 113 , , , cord-024189-t7mbsr25 1237 114 -6 -6 NNP cord-024189-t7mbsr25 1237 115 , , , cord-024189-t7mbsr25 1237 116 and and CC cord-024189-t7mbsr25 1237 117 -10 -10 NN cord-024189-t7mbsr25 1237 118 , , , cord-024189-t7mbsr25 1237 119 and and CC cord-024189-t7mbsr25 1237 120 tumor tumor NN cord-024189-t7mbsr25 1237 121 necrosis necrosis NN cord-024189-t7mbsr25 1237 122 factor factor NN cord-024189-t7mbsr25 1237 123 ( ( -LRB- cord-024189-t7mbsr25 1237 124 TNF)-alpha tnf)-alpha CD cord-024189-t7mbsr25 1237 125 ( ( -LRB- cord-024189-t7mbsr25 1237 126 18 18 CD cord-024189-t7mbsr25 1237 127 , , , cord-024189-t7mbsr25 1237 128 ( ( -LRB- cord-024189-t7mbsr25 1237 129 26 26 CD cord-024189-t7mbsr25 1237 130 ) ) -RRB- cord-024189-t7mbsr25 1237 131 ( ( -LRB- cord-024189-t7mbsr25 1237 132 27 27 CD cord-024189-t7mbsr25 1237 133 ) ) -RRB- cord-024189-t7mbsr25 1237 134 ( ( -LRB- cord-024189-t7mbsr25 1237 135 28 28 CD cord-024189-t7mbsr25 1237 136 ) ) -RRB- cord-024189-t7mbsr25 1237 137 . . . cord-024189-t7mbsr25 1238 1 In in IN cord-024189-t7mbsr25 1238 2 severe severe JJ cord-024189-t7mbsr25 1238 3 cases case NNS cord-024189-t7mbsr25 1238 4 , , , cord-024189-t7mbsr25 1238 5 this this DT cord-024189-t7mbsr25 1238 6 " " `` cord-024189-t7mbsr25 1238 7 cytokine cytokine NN cord-024189-t7mbsr25 1238 8 storm storm NN cord-024189-t7mbsr25 1238 9 " " '' cord-024189-t7mbsr25 1238 10 results result NNS cord-024189-t7mbsr25 1238 11 in in IN cord-024189-t7mbsr25 1238 12 a a DT cord-024189-t7mbsr25 1238 13 macrophage macrophage NN cord-024189-t7mbsr25 1238 14 activation activation NN cord-024189-t7mbsr25 1238 15 syndrome syndrome NN cord-024189-t7mbsr25 1238 16 ( ( -LRB- cord-024189-t7mbsr25 1238 17 MAS MAS NNP cord-024189-t7mbsr25 1238 18 ) ) -RRB- cord-024189-t7mbsr25 1238 19 . . . cord-024189-t7mbsr25 1239 1 Following follow VBG cord-024189-t7mbsr25 1239 2 the the DT cord-024189-t7mbsr25 1239 3 initial initial JJ cord-024189-t7mbsr25 1239 4 recognition recognition NN cord-024189-t7mbsr25 1239 5 of of IN cord-024189-t7mbsr25 1239 6 KD KD NNP cord-024189-t7mbsr25 1239 7 , , , cord-024189-t7mbsr25 1239 8 this this DT cord-024189-t7mbsr25 1239 9 illness illness NN cord-024189-t7mbsr25 1239 10 was be VBD cord-024189-t7mbsr25 1239 11 treated treat VBN cord-024189-t7mbsr25 1239 12 with with IN cord-024189-t7mbsr25 1239 13 salicylates salicylate NNS cord-024189-t7mbsr25 1239 14 , , , cord-024189-t7mbsr25 1239 15 using use VBG cord-024189-t7mbsr25 1239 16 the the DT cord-024189-t7mbsr25 1239 17 same same JJ cord-024189-t7mbsr25 1239 18 doses dose NNS cord-024189-t7mbsr25 1239 19 of of IN cord-024189-t7mbsr25 1239 20 aspirin aspirin NN cord-024189-t7mbsr25 1239 21 employed employ VBN cord-024189-t7mbsr25 1239 22 in in IN cord-024189-t7mbsr25 1239 23 the the DT cord-024189-t7mbsr25 1239 24 treatment treatment NN cord-024189-t7mbsr25 1239 25 of of IN cord-024189-t7mbsr25 1239 26 rheumatic rheumatic JJ cord-024189-t7mbsr25 1239 27 fever fever NN cord-024189-t7mbsr25 1239 28 . . . cord-024189-t7mbsr25 1240 1 Because because IN cord-024189-t7mbsr25 1240 2 of of IN cord-024189-t7mbsr25 1240 3 the the DT cord-024189-t7mbsr25 1240 4 potential potential NN cord-024189-t7mbsr25 1240 5 for for IN cord-024189-t7mbsr25 1240 6 impedance impedance NN cord-024189-t7mbsr25 1240 7 of of IN cord-024189-t7mbsr25 1240 8 aspirin aspirin NN cord-024189-t7mbsr25 1240 9 absorption absorption NN cord-024189-t7mbsr25 1240 10 caused cause VBN cord-024189-t7mbsr25 1240 11 by by IN cord-024189-t7mbsr25 1240 12 vasculitic vasculitic JJ cord-024189-t7mbsr25 1240 13 involvement involvement NN cord-024189-t7mbsr25 1240 14 of of IN cord-024189-t7mbsr25 1240 15 the the DT cord-024189-t7mbsr25 1240 16 gastrointestinal gastrointestinal JJ cord-024189-t7mbsr25 1240 17 tract tract NN cord-024189-t7mbsr25 1240 18 , , , cord-024189-t7mbsr25 1240 19 however however RB cord-024189-t7mbsr25 1240 20 , , , cord-024189-t7mbsr25 1240 21 the the DT cord-024189-t7mbsr25 1240 22 use use NN cord-024189-t7mbsr25 1240 23 of of IN cord-024189-t7mbsr25 1240 24 aspirin aspirin NN cord-024189-t7mbsr25 1240 25 must must MD cord-024189-t7mbsr25 1240 26 be be VB cord-024189-t7mbsr25 1240 27 monitored monitor VBN cord-024189-t7mbsr25 1240 28 carefully carefully RB cord-024189-t7mbsr25 1240 29 in in IN cord-024189-t7mbsr25 1240 30 this this DT cord-024189-t7mbsr25 1240 31 setting setting NN cord-024189-t7mbsr25 1240 32 . . . cord-024189-t7mbsr25 1241 1 If if IN cord-024189-t7mbsr25 1241 2 aspirin aspirin NN cord-024189-t7mbsr25 1241 3 doses dose NNS cord-024189-t7mbsr25 1241 4 are be VBP cord-024189-t7mbsr25 1241 5 too too RB cord-024189-t7mbsr25 1241 6 high high JJ cord-024189-t7mbsr25 1241 7 ( ( -LRB- cord-024189-t7mbsr25 1241 8 e.g. e.g. RB cord-024189-t7mbsr25 1241 9 , , , cord-024189-t7mbsr25 1241 10 100 100 CD cord-024189-t7mbsr25 1241 11 - - SYM cord-024189-t7mbsr25 1241 12 150 150 CD cord-024189-t7mbsr25 1241 13 mg mg NNP cord-024189-t7mbsr25 1241 14 / / SYM cord-024189-t7mbsr25 1241 15 kg kg NNP cord-024189-t7mbsr25 1241 16 / / SYM cord-024189-t7mbsr25 1241 17 day day NN cord-024189-t7mbsr25 1241 18 ) ) -RRB- cord-024189-t7mbsr25 1241 19 , , , cord-024189-t7mbsr25 1241 20 improvement improvement NN cord-024189-t7mbsr25 1241 21 of of IN cord-024189-t7mbsr25 1241 22 intestinal intestinal JJ cord-024189-t7mbsr25 1241 23 absorption absorption NN cord-024189-t7mbsr25 1241 24 with with IN cord-024189-t7mbsr25 1241 25 therapy therapy NN cord-024189-t7mbsr25 1241 26 may may MD cord-024189-t7mbsr25 1241 27 lead lead VB cord-024189-t7mbsr25 1241 28 to to IN cord-024189-t7mbsr25 1241 29 symptoms symptom NNS cord-024189-t7mbsr25 1241 30 of of IN cord-024189-t7mbsr25 1241 31 toxicity toxicity NN cord-024189-t7mbsr25 1241 32 . . . cord-024189-t7mbsr25 1242 1 In in IN cord-024189-t7mbsr25 1242 2 Japan Japan NNP cord-024189-t7mbsr25 1242 3 , , , cord-024189-t7mbsr25 1242 4 doses dose NNS cord-024189-t7mbsr25 1242 5 of of IN cord-024189-t7mbsr25 1242 6 30 30 CD cord-024189-t7mbsr25 1242 7 to to TO cord-024189-t7mbsr25 1242 8 50 50 CD cord-024189-t7mbsr25 1242 9 mg mg NNP cord-024189-t7mbsr25 1242 10 / / SYM cord-024189-t7mbsr25 1242 11 kg kg NNP cord-024189-t7mbsr25 1242 12 / / SYM cord-024189-t7mbsr25 1242 13 day day NN cord-024189-t7mbsr25 1242 14 have have VBP cord-024189-t7mbsr25 1242 15 been be VBN cord-024189-t7mbsr25 1242 16 employed employ VBN cord-024189-t7mbsr25 1242 17 because because IN cord-024189-t7mbsr25 1242 18 of of IN cord-024189-t7mbsr25 1242 19 the the DT cord-024189-t7mbsr25 1242 20 high high JJ cord-024189-t7mbsr25 1242 21 incidence incidence NN cord-024189-t7mbsr25 1242 22 of of IN cord-024189-t7mbsr25 1242 23 the the DT cord-024189-t7mbsr25 1242 24 slowacetylator slowacetylator NN cord-024189-t7mbsr25 1242 25 gene gene NN cord-024189-t7mbsr25 1242 26 in in IN cord-024189-t7mbsr25 1242 27 the the DT cord-024189-t7mbsr25 1242 28 Japanese japanese JJ cord-024189-t7mbsr25 1242 29 population population NN cord-024189-t7mbsr25 1242 30 . . . cord-024189-t7mbsr25 1243 1 A a DT cord-024189-t7mbsr25 1243 2 combined combine VBN cord-024189-t7mbsr25 1243 3 US US NNP cord-024189-t7mbsr25 1243 4 and and CC cord-024189-t7mbsr25 1243 5 Japanese japanese JJ cord-024189-t7mbsr25 1243 6 multicenter multicenter JJ cord-024189-t7mbsr25 1243 7 study study NN cord-024189-t7mbsr25 1243 8 demonstrated demonstrate VBD cord-024189-t7mbsr25 1243 9 that that IN cord-024189-t7mbsr25 1243 10 30 30 CD cord-024189-t7mbsr25 1243 11 to to TO cord-024189-t7mbsr25 1243 12 50 50 CD cord-024189-t7mbsr25 1243 13 mg mg NNS cord-024189-t7mbsr25 1243 14 / / SYM cord-024189-t7mbsr25 1243 15 kg kg NNS cord-024189-t7mbsr25 1243 16 of of IN cord-024189-t7mbsr25 1243 17 aspirin aspirin NN cord-024189-t7mbsr25 1243 18 plus plus CC cord-024189-t7mbsr25 1243 19 IVIG IVIG NNP cord-024189-t7mbsr25 1243 20 ( ( -LRB- cord-024189-t7mbsr25 1243 21 see see VB cord-024189-t7mbsr25 1243 22 below below RB cord-024189-t7mbsr25 1243 23 ) ) -RRB- cord-024189-t7mbsr25 1243 24 was be VBD cord-024189-t7mbsr25 1243 25 effective effective JJ cord-024189-t7mbsr25 1243 26 at at IN cord-024189-t7mbsr25 1243 27 preventing prevent VBG cord-024189-t7mbsr25 1243 28 aneurysm aneurysm NN cord-024189-t7mbsr25 1243 29 formation formation NN cord-024189-t7mbsr25 1243 30 in in IN cord-024189-t7mbsr25 1243 31 most most JJS cord-024189-t7mbsr25 1243 32 cases case NNS cord-024189-t7mbsr25 1243 33 ( ( -LRB- cord-024189-t7mbsr25 1243 34 29 29 CD cord-024189-t7mbsr25 1243 35 ) ) -RRB- cord-024189-t7mbsr25 1243 36 . . . cord-024189-t7mbsr25 1244 1 Current current JJ cord-024189-t7mbsr25 1244 2 AHA AHA NNP cord-024189-t7mbsr25 1244 3 guidelines guideline NNS cord-024189-t7mbsr25 1244 4 , , , cord-024189-t7mbsr25 1244 5 however however RB cord-024189-t7mbsr25 1244 6 , , , cord-024189-t7mbsr25 1244 7 endorse endorse VB cord-024189-t7mbsr25 1244 8 aspirin aspirin NN cord-024189-t7mbsr25 1244 9 doses dose NNS cord-024189-t7mbsr25 1244 10 of of IN cord-024189-t7mbsr25 1244 11 80 80 CD cord-024189-t7mbsr25 1244 12 to to TO cord-024189-t7mbsr25 1244 13 100 100 CD cord-024189-t7mbsr25 1244 14 mg mg NNP cord-024189-t7mbsr25 1244 15 / / SYM cord-024189-t7mbsr25 1244 16 kg kg NNP cord-024189-t7mbsr25 1244 17 / / SYM cord-024189-t7mbsr25 1244 18 day day NN cord-024189-t7mbsr25 1244 19 , , , cord-024189-t7mbsr25 1244 20 in in IN cord-024189-t7mbsr25 1244 21 four four CD cord-024189-t7mbsr25 1244 22 divided divide VBN cord-024189-t7mbsr25 1244 23 doses dose NNS cord-024189-t7mbsr25 1244 24 ( ( -LRB- cord-024189-t7mbsr25 1244 25 Table table NN cord-024189-t7mbsr25 1244 26 21F-4 21f-4 CD cord-024189-t7mbsr25 1244 27 ) ) -RRB- cord-024189-t7mbsr25 1244 28 . . . cord-024189-t7mbsr25 1245 1 Furusho furusho NN cord-024189-t7mbsr25 1245 2 studied study VBD cord-024189-t7mbsr25 1245 3 the the DT cord-024189-t7mbsr25 1245 4 use use NN cord-024189-t7mbsr25 1245 5 of of IN cord-024189-t7mbsr25 1245 6 aspirin aspirin NN cord-024189-t7mbsr25 1245 7 alone alone JJ cord-024189-t7mbsr25 1245 8 versus versus IN cord-024189-t7mbsr25 1245 9 the the DT cord-024189-t7mbsr25 1245 10 combination combination NN cord-024189-t7mbsr25 1245 11 of of IN cord-024189-t7mbsr25 1245 12 aspirin aspirin NN cord-024189-t7mbsr25 1245 13 plus plus CC cord-024189-t7mbsr25 1245 14 IVIG IVIG NNP cord-024189-t7mbsr25 1245 15 ( ( -LRB- cord-024189-t7mbsr25 1245 16 0.4 0.4 CD cord-024189-t7mbsr25 1245 17 mg mg NNP cord-024189-t7mbsr25 1245 18 / / SYM cord-024189-t7mbsr25 1245 19 kg kg NNP cord-024189-t7mbsr25 1245 20 / / SYM cord-024189-t7mbsr25 1245 21 day day NN cord-024189-t7mbsr25 1245 22 × × NN cord-024189-t7mbsr25 1245 23 4 4 CD cord-024189-t7mbsr25 1245 24 days day NNS cord-024189-t7mbsr25 1245 25 ) ) -RRB- cord-024189-t7mbsr25 1245 26 , , , cord-024189-t7mbsr25 1245 27 using use VBG cord-024189-t7mbsr25 1245 28 a a DT cord-024189-t7mbsr25 1245 29 protocol protocol NN cord-024189-t7mbsr25 1245 30 then then RB cord-024189-t7mbsr25 1245 31 in in IN cord-024189-t7mbsr25 1245 32 use use NN cord-024189-t7mbsr25 1245 33 for for IN cord-024189-t7mbsr25 1245 34 immune immune JJ cord-024189-t7mbsr25 1245 35 thrombocytopenic thrombocytopenic JJ cord-024189-t7mbsr25 1245 36 purpura purpura NN cord-024189-t7mbsr25 1245 37 ( ( -LRB- cord-024189-t7mbsr25 1245 38 30 30 CD cord-024189-t7mbsr25 1245 39 ) ) -RRB- cord-024189-t7mbsr25 1245 40 . . . cord-024189-t7mbsr25 1246 1 A a DT cord-024189-t7mbsr25 1246 2 multicenter multicenter JJ cord-024189-t7mbsr25 1246 3 study study NN cord-024189-t7mbsr25 1246 4 demonstrated demonstrate VBD cord-024189-t7mbsr25 1246 5 a a DT cord-024189-t7mbsr25 1246 6 decrease decrease NN cord-024189-t7mbsr25 1246 7 in in IN cord-024189-t7mbsr25 1246 8 the the DT cord-024189-t7mbsr25 1246 9 incidence incidence NN cord-024189-t7mbsr25 1246 10 of of IN cord-024189-t7mbsr25 1246 11 coronary coronary JJ cord-024189-t7mbsr25 1246 12 artery artery NN cord-024189-t7mbsr25 1246 13 abnormalities abnormality NNS cord-024189-t7mbsr25 1246 14 : : : cord-024189-t7mbsr25 1246 15 only only RB cord-024189-t7mbsr25 1246 16 4 4 CD cord-024189-t7mbsr25 1246 17 % % NN cord-024189-t7mbsr25 1246 18 ( ( -LRB- cord-024189-t7mbsr25 1246 19 3 3 CD cord-024189-t7mbsr25 1246 20 of of IN cord-024189-t7mbsr25 1246 21 68 68 CD cord-024189-t7mbsr25 1246 22 ) ) -RRB- cord-024189-t7mbsr25 1246 23 in in IN cord-024189-t7mbsr25 1246 24 the the DT cord-024189-t7mbsr25 1246 25 IVIG IVIG NNP cord-024189-t7mbsr25 1246 26 group group NN cord-024189-t7mbsr25 1246 27 , , , cord-024189-t7mbsr25 1246 28 compared compare VBN cord-024189-t7mbsr25 1246 29 with with IN cord-024189-t7mbsr25 1246 30 33 33 CD cord-024189-t7mbsr25 1246 31 % % NN cord-024189-t7mbsr25 1246 32 ( ( -LRB- cord-024189-t7mbsr25 1246 33 38 38 CD cord-024189-t7mbsr25 1246 34 of of IN cord-024189-t7mbsr25 1246 35 119 119 CD cord-024189-t7mbsr25 1246 36 ) ) -RRB- cord-024189-t7mbsr25 1246 37 in in IN cord-024189-t7mbsr25 1246 38 the the DT cord-024189-t7mbsr25 1246 39 aspirin aspirin NN cord-024189-t7mbsr25 1246 40 - - HYPH cord-024189-t7mbsr25 1246 41 only only JJ cord-024189-t7mbsr25 1246 42 arm arm NN cord-024189-t7mbsr25 1246 43 ( ( -LRB- cord-024189-t7mbsr25 1246 44 31 31 CD cord-024189-t7mbsr25 1246 45 ) ) -RRB- cord-024189-t7mbsr25 1246 46 . . . cord-024189-t7mbsr25 1247 1 No no DT cord-024189-t7mbsr25 1247 2 patients patient NNS cord-024189-t7mbsr25 1247 3 in in IN cord-024189-t7mbsr25 1247 4 the the DT cord-024189-t7mbsr25 1247 5 IVIG IVIG NNP cord-024189-t7mbsr25 1247 6 arm arm NN cord-024189-t7mbsr25 1247 7 developed develop VBD cord-024189-t7mbsr25 1247 8 giant giant JJ cord-024189-t7mbsr25 1247 9 coronary coronary JJ cord-024189-t7mbsr25 1247 10 artery artery NN cord-024189-t7mbsr25 1247 11 aneurysms aneurysm NNS cord-024189-t7mbsr25 1247 12 . . . cord-024189-t7mbsr25 1248 1 In in IN cord-024189-t7mbsr25 1248 2 contrast contrast NN cord-024189-t7mbsr25 1248 3 , , , cord-024189-t7mbsr25 1248 4 6 6 CD cord-024189-t7mbsr25 1248 5 % % NN cord-024189-t7mbsr25 1248 6 of of IN cord-024189-t7mbsr25 1248 7 the the DT cord-024189-t7mbsr25 1248 8 aspirinonly aspirinonly NNP cord-024189-t7mbsr25 1248 9 group group NN cord-024189-t7mbsr25 1248 10 suffered suffer VBD cord-024189-t7mbsr25 1248 11 this this DT cord-024189-t7mbsr25 1248 12 occurrence occurrence NN cord-024189-t7mbsr25 1248 13 . . . cord-024189-t7mbsr25 1249 1 This this DT cord-024189-t7mbsr25 1249 2 study study NN cord-024189-t7mbsr25 1249 3 established establish VBD cord-024189-t7mbsr25 1249 4 IVIG IVIG NNP cord-024189-t7mbsr25 1249 5 as as IN cord-024189-t7mbsr25 1249 6 the the DT cord-024189-t7mbsr25 1249 7 standard standard NN cord-024189-t7mbsr25 1249 8 of of IN cord-024189-t7mbsr25 1249 9 care care NN cord-024189-t7mbsr25 1249 10 . . . cord-024189-t7mbsr25 1250 1 Several several JJ cord-024189-t7mbsr25 1250 2 years year NNS cord-024189-t7mbsr25 1250 3 later later RB cord-024189-t7mbsr25 1250 4 , , , cord-024189-t7mbsr25 1250 5 a a DT cord-024189-t7mbsr25 1250 6 follow follow VB cord-024189-t7mbsr25 1250 7 - - HYPH cord-024189-t7mbsr25 1250 8 up up NN cord-024189-t7mbsr25 1250 9 trial trial NN cord-024189-t7mbsr25 1250 10 compared compare VBD cord-024189-t7mbsr25 1250 11 a a DT cord-024189-t7mbsr25 1250 12 single single JJ cord-024189-t7mbsr25 1250 13 dose dose NN cord-024189-t7mbsr25 1250 14 of of IN cord-024189-t7mbsr25 1250 15 IVIG IVIG NNP cord-024189-t7mbsr25 1250 16 ( ( -LRB- cord-024189-t7mbsr25 1250 17 2 2 CD cord-024189-t7mbsr25 1250 18 g g NN cord-024189-t7mbsr25 1250 19 / / SYM cord-024189-t7mbsr25 1250 20 kg kg NNP cord-024189-t7mbsr25 1250 21 ) ) -RRB- cord-024189-t7mbsr25 1250 22 to to IN cord-024189-t7mbsr25 1250 23 the the DT cord-024189-t7mbsr25 1250 24 traditional traditional JJ cord-024189-t7mbsr25 1250 25 0.4 0.4 CD cord-024189-t7mbsr25 1250 26 mg mg NNP cord-024189-t7mbsr25 1250 27 / / SYM cord-024189-t7mbsr25 1250 28 kg kg NNP cord-024189-t7mbsr25 1250 29 / / SYM cord-024189-t7mbsr25 1250 30 day day NN cord-024189-t7mbsr25 1250 31 × × NNP cord-024189-t7mbsr25 1250 32 4 4 CD cord-024189-t7mbsr25 1250 33 schedule schedule NN cord-024189-t7mbsr25 1250 34 , , , cord-024189-t7mbsr25 1250 35 confi confi NNP cord-024189-t7mbsr25 1250 36 rming rme VBG cord-024189-t7mbsr25 1250 37 the the DT cord-024189-t7mbsr25 1250 38 superiority superiority NN cord-024189-t7mbsr25 1250 39 ( ( -LRB- cord-024189-t7mbsr25 1250 40 a a DT cord-024189-t7mbsr25 1250 41 further further JJ cord-024189-t7mbsr25 1250 42 lowering lowering NN cord-024189-t7mbsr25 1250 43 of of IN cord-024189-t7mbsr25 1250 44 the the DT cord-024189-t7mbsr25 1250 45 coronary coronary JJ cord-024189-t7mbsr25 1250 46 aneurysm aneurysm NN cord-024189-t7mbsr25 1250 47 rate rate NN cord-024189-t7mbsr25 1250 48 ) ) -RRB- cord-024189-t7mbsr25 1250 49 of of IN cord-024189-t7mbsr25 1250 50 the the DT cord-024189-t7mbsr25 1250 51 single single JJ cord-024189-t7mbsr25 1250 52 - - HYPH cord-024189-t7mbsr25 1250 53 dose dose NN cord-024189-t7mbsr25 1250 54 regimen regimen NN cord-024189-t7mbsr25 1250 55 ( ( -LRB- cord-024189-t7mbsr25 1250 56 32 32 CD cord-024189-t7mbsr25 1250 57 ) ) -RRB- cord-024189-t7mbsr25 1250 58 . . . cord-024189-t7mbsr25 1251 1 Thereafter thereafter RB cord-024189-t7mbsr25 1251 2 , , , cord-024189-t7mbsr25 1251 3 the the DT cord-024189-t7mbsr25 1251 4 single single JJ cord-024189-t7mbsr25 1251 5 - - HYPH cord-024189-t7mbsr25 1251 6 dose dose NN cord-024189-t7mbsr25 1251 7 regimen regimen NN cord-024189-t7mbsr25 1251 8 became become VBD cord-024189-t7mbsr25 1251 9 the the DT cord-024189-t7mbsr25 1251 10 standard standard NN cord-024189-t7mbsr25 1251 11 of of IN cord-024189-t7mbsr25 1251 12 care care NN cord-024189-t7mbsr25 1251 13 recommendation recommendation NN cord-024189-t7mbsr25 1251 14 by by IN cord-024189-t7mbsr25 1251 15 the the DT cord-024189-t7mbsr25 1251 16 AHA AHA NNP cord-024189-t7mbsr25 1251 17 ( ( -LRB- cord-024189-t7mbsr25 1251 18 Table table NN cord-024189-t7mbsr25 1251 19 _SP cord-024189-t7mbsr25 1251 20 21F 21f NN cord-024189-t7mbsr25 1251 21 -4 -4 NNP cord-024189-t7mbsr25 1251 22 ) ) -RRB- cord-024189-t7mbsr25 1251 23 ( ( -LRB- cord-024189-t7mbsr25 1251 24 9,33 9,33 CD cord-024189-t7mbsr25 1251 25 ) ) -RRB- cord-024189-t7mbsr25 1251 26 . . . cord-024189-t7mbsr25 1252 1 The the DT cord-024189-t7mbsr25 1252 2 use use NN cord-024189-t7mbsr25 1252 3 of of IN cord-024189-t7mbsr25 1252 4 glucocorticoids glucocorticoid NNS cord-024189-t7mbsr25 1252 5 in in IN cord-024189-t7mbsr25 1252 6 KD KD NNP cord-024189-t7mbsr25 1252 7 is be VBZ cord-024189-t7mbsr25 1252 8 , , , cord-024189-t7mbsr25 1252 9 surprisingly surprisingly RB cord-024189-t7mbsr25 1252 10 , , , cord-024189-t7mbsr25 1252 11 controversial controversial JJ cord-024189-t7mbsr25 1252 12 . . . cord-024189-t7mbsr25 1253 1 One one CD cord-024189-t7mbsr25 1253 2 retrospective retrospective JJ cord-024189-t7mbsr25 1253 3 study study NN cord-024189-t7mbsr25 1253 4 assessed assess VBD cord-024189-t7mbsr25 1253 5 the the DT cord-024189-t7mbsr25 1253 6 outcomes outcome NNS cord-024189-t7mbsr25 1253 7 of of IN cord-024189-t7mbsr25 1253 8 fi fi NNP cord-024189-t7mbsr25 1253 9 ve ve VBD cord-024189-t7mbsr25 1253 10 different different JJ cord-024189-t7mbsr25 1253 11 treatment treatment NN cord-024189-t7mbsr25 1253 12 regimens regimen NNS cord-024189-t7mbsr25 1253 13 , , , cord-024189-t7mbsr25 1253 14 including include VBG cord-024189-t7mbsr25 1253 15 aspirin aspirin NN cord-024189-t7mbsr25 1253 16 alone alone RB cord-024189-t7mbsr25 1253 17 , , , cord-024189-t7mbsr25 1253 18 aspirin aspirin NN cord-024189-t7mbsr25 1253 19 plus plus CC cord-024189-t7mbsr25 1253 20 prednisolone prednisolone NN cord-024189-t7mbsr25 1253 21 , , , cord-024189-t7mbsr25 1253 22 prednisolone prednisolone NN cord-024189-t7mbsr25 1253 23 alone alone RB cord-024189-t7mbsr25 1253 24 , , , cord-024189-t7mbsr25 1253 25 prednisolone prednisolone NN cord-024189-t7mbsr25 1253 26 plus plus CC cord-024189-t7mbsr25 1253 27 warfarin warfarin NN cord-024189-t7mbsr25 1253 28 , , , cord-024189-t7mbsr25 1253 29 and and CC cord-024189-t7mbsr25 1253 30 no no DT cord-024189-t7mbsr25 1253 31 treatment treatment NN cord-024189-t7mbsr25 1253 32 aside aside RB cord-024189-t7mbsr25 1253 33 from from IN cord-024189-t7mbsr25 1253 34 background background NN cord-024189-t7mbsr25 1253 35 antibiotic antibiotic JJ cord-024189-t7mbsr25 1253 36 therapy therapy NN cord-024189-t7mbsr25 1253 37 ( ( -LRB- cord-024189-t7mbsr25 1253 38 which which WDT cord-024189-t7mbsr25 1253 39 all all DT cord-024189-t7mbsr25 1253 40 other other JJ cord-024189-t7mbsr25 1253 41 treatment treatment NN cord-024189-t7mbsr25 1253 42 groups group NNS cord-024189-t7mbsr25 1253 43 received receive VBN cord-024189-t7mbsr25 1253 44 , , , cord-024189-t7mbsr25 1253 45 as as RB cord-024189-t7mbsr25 1253 46 well well RB cord-024189-t7mbsr25 1253 47 ) ) -RRB- cord-024189-t7mbsr25 1253 48 . . . cord-024189-t7mbsr25 1254 1 Although although IN cord-024189-t7mbsr25 1254 2 aspirin aspirin NN cord-024189-t7mbsr25 1254 3 alone alone RB cord-024189-t7mbsr25 1254 4 reduced reduce VBD cord-024189-t7mbsr25 1254 5 the the DT cord-024189-t7mbsr25 1254 6 aneurysm aneurysm NN cord-024189-t7mbsr25 1254 7 rate rate NN cord-024189-t7mbsr25 1254 8 from from IN cord-024189-t7mbsr25 1254 9 20 20 CD cord-024189-t7mbsr25 1254 10 % % NN cord-024189-t7mbsr25 1254 11 to to IN cord-024189-t7mbsr25 1254 12 11 11 CD cord-024189-t7mbsr25 1254 13 % % NN cord-024189-t7mbsr25 1254 14 compared compare VBN cord-024189-t7mbsr25 1254 15 with with IN cord-024189-t7mbsr25 1254 16 the the DT cord-024189-t7mbsr25 1254 17 no no DT cord-024189-t7mbsr25 1254 18 - - HYPH cord-024189-t7mbsr25 1254 19 treatment treatment NN cord-024189-t7mbsr25 1254 20 group group NN cord-024189-t7mbsr25 1254 21 , , , cord-024189-t7mbsr25 1254 22 treatment treatment NN cord-024189-t7mbsr25 1254 23 with with IN cord-024189-t7mbsr25 1254 24 prednisolone prednisolone NN cord-024189-t7mbsr25 1254 25 was be VBD cord-024189-t7mbsr25 1254 26 associated associate VBN cord-024189-t7mbsr25 1254 27 with with IN cord-024189-t7mbsr25 1254 28 an an DT cord-024189-t7mbsr25 1254 29 increase increase NN cord-024189-t7mbsr25 1254 30 in in IN cord-024189-t7mbsr25 1254 31 the the DT cord-024189-t7mbsr25 1254 32 percentages percentage NNS cord-024189-t7mbsr25 1254 33 of of IN cord-024189-t7mbsr25 1254 34 patients patient NNS cord-024189-t7mbsr25 1254 35 who who WP cord-024189-t7mbsr25 1254 36 developed develop VBD cord-024189-t7mbsr25 1254 37 aneurysm aneurysm NN cord-024189-t7mbsr25 1254 38 to to IN cord-024189-t7mbsr25 1254 39 67 67 CD cord-024189-t7mbsr25 1254 40 % % NN cord-024189-t7mbsr25 1254 41 ( ( -LRB- cord-024189-t7mbsr25 1254 42 34 34 CD cord-024189-t7mbsr25 1254 43 ) ) -RRB- cord-024189-t7mbsr25 1254 44 . . . cord-024189-t7mbsr25 1255 1 Of of IN cord-024189-t7mbsr25 1255 2 note note NN cord-024189-t7mbsr25 1255 3 , , , cord-024189-t7mbsr25 1255 4 the the DT cord-024189-t7mbsr25 1255 5 seven seven CD cord-024189-t7mbsr25 1255 6 patients patient NNS cord-024189-t7mbsr25 1255 7 treated treat VBN cord-024189-t7mbsr25 1255 8 with with IN cord-024189-t7mbsr25 1255 9 aspirin aspirin NN cord-024189-t7mbsr25 1255 10 plus plus CC cord-024189-t7mbsr25 1255 11 prednisolone prednisolone NN cord-024189-t7mbsr25 1255 12 - - HYPH cord-024189-t7mbsr25 1255 13 none none NN cord-024189-t7mbsr25 1255 14 of of IN cord-024189-t7mbsr25 1255 15 whom whom WP cord-024189-t7mbsr25 1255 16 developed develop VBD cord-024189-t7mbsr25 1255 17 aneurysm aneurysm NN cord-024189-t7mbsr25 1255 18 - - , cord-024189-t7mbsr25 1255 19 were be VBD cord-024189-t7mbsr25 1255 20 not not RB cord-024189-t7mbsr25 1255 21 emphasized emphasize VBN cord-024189-t7mbsr25 1255 22 in in IN cord-024189-t7mbsr25 1255 23 the the DT cord-024189-t7mbsr25 1255 24 discussion discussion NN cord-024189-t7mbsr25 1255 25 . . . cord-024189-t7mbsr25 1256 1 In in IN cord-024189-t7mbsr25 1256 2 addition addition NN cord-024189-t7mbsr25 1256 3 , , , cord-024189-t7mbsr25 1256 4 the the DT cord-024189-t7mbsr25 1256 5 patients patient NNS cord-024189-t7mbsr25 1256 6 in in IN cord-024189-t7mbsr25 1256 7 the the DT cord-024189-t7mbsr25 1256 8 prednisolone prednisolone NN cord-024189-t7mbsr25 1256 9 - - HYPH cord-024189-t7mbsr25 1256 10 only only JJ cord-024189-t7mbsr25 1256 11 group group NN cord-024189-t7mbsr25 1256 12 were be VBD cord-024189-t7mbsr25 1256 13 perhaps perhaps RB cord-024189-t7mbsr25 1256 14 the the DT cord-024189-t7mbsr25 1256 15 most most RBS cord-024189-t7mbsr25 1256 16 ill ill JJ cord-024189-t7mbsr25 1256 17 at at IN cord-024189-t7mbsr25 1256 18 baseline baseline NN cord-024189-t7mbsr25 1256 19 ( ( -LRB- cord-024189-t7mbsr25 1256 20 and and CC cord-024189-t7mbsr25 1256 21 hence hence RB cord-024189-t7mbsr25 1256 22 were be VBD cord-024189-t7mbsr25 1256 23 treated treat VBN cord-024189-t7mbsr25 1256 24 with with IN cord-024189-t7mbsr25 1256 25 glucocorticoids glucocorticoid NNS cord-024189-t7mbsr25 1256 26 , , , cord-024189-t7mbsr25 1256 27 presumed presume VBN cord-024189-t7mbsr25 1256 28 empirically empirically RB cord-024189-t7mbsr25 1256 29 to to TO cord-024189-t7mbsr25 1256 30 be be VB cord-024189-t7mbsr25 1256 31 the the DT cord-024189-t7mbsr25 1256 32 most most RBS cord-024189-t7mbsr25 1256 33 powerful powerful JJ cord-024189-t7mbsr25 1256 34 therapy therapy NN cord-024189-t7mbsr25 1256 35 ) ) -RRB- cord-024189-t7mbsr25 1256 36 . . . cord-024189-t7mbsr25 1257 1 After after IN cord-024189-t7mbsr25 1257 2 the the DT cord-024189-t7mbsr25 1257 3 publication publication NN cord-024189-t7mbsr25 1257 4 of of IN cord-024189-t7mbsr25 1257 5 this this DT cord-024189-t7mbsr25 1257 6 study study NN cord-024189-t7mbsr25 1257 7 's 's POS cord-024189-t7mbsr25 1257 8 results result NNS cord-024189-t7mbsr25 1257 9 , , , cord-024189-t7mbsr25 1257 10 glucocorticoids glucocorticoid NNS cord-024189-t7mbsr25 1257 11 for for IN cord-024189-t7mbsr25 1257 12 the the DT cord-024189-t7mbsr25 1257 13 treatment treatment NN cord-024189-t7mbsr25 1257 14 of of IN cord-024189-t7mbsr25 1257 15 KD KD NNP cord-024189-t7mbsr25 1257 16 fell fall VBD cord-024189-t7mbsr25 1257 17 into into IN cord-024189-t7mbsr25 1257 18 disfavor disfavor NN cord-024189-t7mbsr25 1257 19 among among IN cord-024189-t7mbsr25 1257 20 pediatricians pediatrician NNS cord-024189-t7mbsr25 1257 21 and and CC cord-024189-t7mbsr25 1257 22 in in IN cord-024189-t7mbsr25 1257 23 fact fact NN cord-024189-t7mbsr25 1257 24 were be VBD cord-024189-t7mbsr25 1257 25 viewed view VBN cord-024189-t7mbsr25 1257 26 as as IN cord-024189-t7mbsr25 1257 27 contraindicated contraindicated JJ cord-024189-t7mbsr25 1257 28 for for IN cord-024189-t7mbsr25 1257 29 this this DT cord-024189-t7mbsr25 1257 30 disease disease NN cord-024189-t7mbsr25 1257 31 . . . cord-024189-t7mbsr25 1258 1 More more RBR cord-024189-t7mbsr25 1258 2 recent recent JJ cord-024189-t7mbsr25 1258 3 case case NN cord-024189-t7mbsr25 1258 4 series series NN cord-024189-t7mbsr25 1258 5 , , , cord-024189-t7mbsr25 1258 6 evaluating evaluate VBG cord-024189-t7mbsr25 1258 7 the the DT cord-024189-t7mbsr25 1258 8 use use NN cord-024189-t7mbsr25 1258 9 of of IN cord-024189-t7mbsr25 1258 10 pulse pulse NN cord-024189-t7mbsr25 1258 11 methylprednisolone methylprednisolone NN cord-024189-t7mbsr25 1258 12 as as IN cord-024189-t7mbsr25 1258 13 rescue rescue NN cord-024189-t7mbsr25 1258 14 therapy therapy NN cord-024189-t7mbsr25 1258 15 for for IN cord-024189-t7mbsr25 1258 16 IVIG IVIG NNP cord-024189-t7mbsr25 1258 17 nonresponders nonresponder NNS cord-024189-t7mbsr25 1258 18 , , , cord-024189-t7mbsr25 1258 19 have have VBP cord-024189-t7mbsr25 1258 20 been be VBN cord-024189-t7mbsr25 1258 21 more more RBR cord-024189-t7mbsr25 1258 22 encouraging encouraging JJ cord-024189-t7mbsr25 1258 23 with with IN cord-024189-t7mbsr25 1258 24 regard regard NN cord-024189-t7mbsr25 1258 25 to to IN cord-024189-t7mbsr25 1258 26 the the DT cord-024189-t7mbsr25 1258 27 potential potential NN cord-024189-t7mbsr25 1258 28 for for IN cord-024189-t7mbsr25 1258 29 a a DT cord-024189-t7mbsr25 1258 30 benefi benefi JJ cord-024189-t7mbsr25 1258 31 cial cial JJ cord-024189-t7mbsr25 1258 32 effect effect NN cord-024189-t7mbsr25 1258 33 of of IN cord-024189-t7mbsr25 1258 34 glucocorticoids glucocorticoid NNS cord-024189-t7mbsr25 1258 35 ( ( -LRB- cord-024189-t7mbsr25 1258 36 35 35 CD cord-024189-t7mbsr25 1258 37 ) ) -RRB- cord-024189-t7mbsr25 1258 38 ( ( -LRB- cord-024189-t7mbsr25 1258 39 36 36 CD cord-024189-t7mbsr25 1258 40 ) ) -RRB- cord-024189-t7mbsr25 1258 41 ( ( -LRB- cord-024189-t7mbsr25 1258 42 37 37 CD cord-024189-t7mbsr25 1258 43 ) ) -RRB- cord-024189-t7mbsr25 1258 44 . . . cord-024189-t7mbsr25 1259 1 Initial initial JJ cord-024189-t7mbsr25 1259 2 results result NNS cord-024189-t7mbsr25 1259 3 from from IN cord-024189-t7mbsr25 1259 4 a a DT cord-024189-t7mbsr25 1259 5 multicenter multicenter JJ cord-024189-t7mbsr25 1259 6 trial trial NN cord-024189-t7mbsr25 1259 7 ( ( -LRB- cord-024189-t7mbsr25 1259 8 38 38 CD cord-024189-t7mbsr25 1259 9 ) ) -RRB- cord-024189-t7mbsr25 1259 10 indicate indicate VBP cord-024189-t7mbsr25 1259 11 no no DT cord-024189-t7mbsr25 1259 12 worsening worsen VBG cord-024189-t7mbsr25 1259 13 in in IN cord-024189-t7mbsr25 1259 14 the the DT cord-024189-t7mbsr25 1259 15 coronary coronary JJ cord-024189-t7mbsr25 1259 16 aneurysm aneurysm NN cord-024189-t7mbsr25 1259 17 rate rate NN cord-024189-t7mbsr25 1259 18 among among IN cord-024189-t7mbsr25 1259 19 patients patient NNS cord-024189-t7mbsr25 1259 20 treated treat VBN cord-024189-t7mbsr25 1259 21 with with IN cord-024189-t7mbsr25 1259 22 glucocorticoids glucocorticoid NNS cord-024189-t7mbsr25 1259 23 , , , cord-024189-t7mbsr25 1259 24 and and CC cord-024189-t7mbsr25 1259 25 a a DT cord-024189-t7mbsr25 1259 26 decrease decrease NN cord-024189-t7mbsr25 1259 27 in in IN cord-024189-t7mbsr25 1259 28 fever fever NN cord-024189-t7mbsr25 1259 29 , , , cord-024189-t7mbsr25 1259 30 infl infl NNP cord-024189-t7mbsr25 1259 31 ammatory ammatory NN cord-024189-t7mbsr25 1259 32 markers marker NNS cord-024189-t7mbsr25 1259 33 , , , cord-024189-t7mbsr25 1259 34 length length NN cord-024189-t7mbsr25 1259 35 of of IN cord-024189-t7mbsr25 1259 36 hospital hospital NN cord-024189-t7mbsr25 1259 37 stay stay NN cord-024189-t7mbsr25 1259 38 , , , cord-024189-t7mbsr25 1259 39 and and CC cord-024189-t7mbsr25 1259 40 IVIG IVIG NNP cord-024189-t7mbsr25 1259 41 side side NN cord-024189-t7mbsr25 1259 42 effects effect NNS cord-024189-t7mbsr25 1259 43 . . . cord-024189-t7mbsr25 1260 1 A a DT cord-024189-t7mbsr25 1260 2 consensus consensus NN cord-024189-t7mbsr25 1260 3 conference conference NN cord-024189-t7mbsr25 1260 4 at at IN cord-024189-t7mbsr25 1260 5 the the DT cord-024189-t7mbsr25 1260 6 National National NNP cord-024189-t7mbsr25 1260 7 Institutes Institutes NNPS cord-024189-t7mbsr25 1260 8 of of IN cord-024189-t7mbsr25 1260 9 Health Health NNP cord-024189-t7mbsr25 1260 10 ( ( -LRB- cord-024189-t7mbsr25 1260 11 18 18 CD cord-024189-t7mbsr25 1260 12 ) ) -RRB- cord-024189-t7mbsr25 1260 13 was be VBD cord-024189-t7mbsr25 1260 14 prompted prompt VBN cord-024189-t7mbsr25 1260 15 by by IN cord-024189-t7mbsr25 1260 16 the the DT cord-024189-t7mbsr25 1260 17 recognition recognition NN cord-024189-t7mbsr25 1260 18 of of IN cord-024189-t7mbsr25 1260 19 an an DT cord-024189-t7mbsr25 1260 20 ongoing ongoing JJ cord-024189-t7mbsr25 1260 21 immune immune JJ cord-024189-t7mbsr25 1260 22 activation activation NN cord-024189-t7mbsr25 1260 23 at at IN cord-024189-t7mbsr25 1260 24 microvascular microvascular JJ cord-024189-t7mbsr25 1260 25 levels level NNS cord-024189-t7mbsr25 1260 26 in in IN cord-024189-t7mbsr25 1260 27 patients patient NNS cord-024189-t7mbsr25 1260 28 treated treat VBN cord-024189-t7mbsr25 1260 29 adequately adequately RB cord-024189-t7mbsr25 1260 30 by by IN cord-024189-t7mbsr25 1260 31 the the DT cord-024189-t7mbsr25 1260 32 current current JJ cord-024189-t7mbsr25 1260 33 therapies therapy NNS cord-024189-t7mbsr25 1260 34 . . . cord-024189-t7mbsr25 1261 1 Outcome outcome NN cord-024189-t7mbsr25 1261 2 data datum NNS cord-024189-t7mbsr25 1261 3 from from IN cord-024189-t7mbsr25 1261 4 Japan Japan NNP cord-024189-t7mbsr25 1261 5 with with IN cord-024189-t7mbsr25 1261 6 long long JJ cord-024189-t7mbsr25 1261 7 - - HYPH cord-024189-t7mbsr25 1261 8 term term NN cord-024189-t7mbsr25 1261 9 ( ( -LRB- cord-024189-t7mbsr25 1261 10 10 10 CD cord-024189-t7mbsr25 1261 11 - - SYM cord-024189-t7mbsr25 1261 12 15 15 CD cord-024189-t7mbsr25 1261 13 year year NN cord-024189-t7mbsr25 1261 14 ) ) -RRB- cord-024189-t7mbsr25 1261 15 follow follow NN cord-024189-t7mbsr25 1261 16 - - HYPH cord-024189-t7mbsr25 1261 17 up up NN cord-024189-t7mbsr25 1261 18 demonstrated demonstrate VBD cord-024189-t7mbsr25 1261 19 persistence persistence NN cord-024189-t7mbsr25 1261 20 of of IN cord-024189-t7mbsr25 1261 21 disease disease NN cord-024189-t7mbsr25 1261 22 in in IN cord-024189-t7mbsr25 1261 23 some some DT cord-024189-t7mbsr25 1261 24 cases case NNS cord-024189-t7mbsr25 1261 25 , , , cord-024189-t7mbsr25 1261 26 with with IN cord-024189-t7mbsr25 1261 27 intravascular intravascular JJ cord-024189-t7mbsr25 1261 28 ultrasound ultrasound NN cord-024189-t7mbsr25 1261 29 and and CC cord-024189-t7mbsr25 1261 30 ultrafast ultrafast NN cord-024189-t7mbsr25 1261 31 computed compute VBN cord-024189-t7mbsr25 1261 32 tomography tomography NN cord-024189-t7mbsr25 1261 33 studies study NNS cord-024189-t7mbsr25 1261 34 demonstrating demonstrate VBG cord-024189-t7mbsr25 1261 35 lingering linger VBG cord-024189-t7mbsr25 1261 36 coronary coronary JJ cord-024189-t7mbsr25 1261 37 aneurysms aneurysm NNS cord-024189-t7mbsr25 1261 38 and/or and/or CC cord-024189-t7mbsr25 1261 39 wall wall NN cord-024189-t7mbsr25 1261 40 fi fi IN cord-024189-t7mbsr25 1261 41 brosis brosis NN cord-024189-t7mbsr25 1261 42 . . . cord-024189-t7mbsr25 1262 1 Of of IN cord-024189-t7mbsr25 1262 2 greatest great JJS cord-024189-t7mbsr25 1262 3 alarm alarm NN cord-024189-t7mbsr25 1262 4 was be VBD cord-024189-t7mbsr25 1262 5 the the DT cord-024189-t7mbsr25 1262 6 fi fi NN cord-024189-t7mbsr25 1262 7 nding nding NN cord-024189-t7mbsr25 1262 8 of of IN cord-024189-t7mbsr25 1262 9 such such JJ cord-024189-t7mbsr25 1262 10 abnormalities abnormality NNS cord-024189-t7mbsr25 1262 11 in in IN cord-024189-t7mbsr25 1262 12 areas area NNS cord-024189-t7mbsr25 1262 13 of of IN cord-024189-t7mbsr25 1262 14 the the DT cord-024189-t7mbsr25 1262 15 vasculature vasculature NN cord-024189-t7mbsr25 1262 16 previously previously RB cord-024189-t7mbsr25 1262 17 documented document VBN cord-024189-t7mbsr25 1262 18 as as IN cord-024189-t7mbsr25 1262 19 normal normal JJ cord-024189-t7mbsr25 1262 20 by by IN cord-024189-t7mbsr25 1262 21 echocardiogram echocardiogram NN cord-024189-t7mbsr25 1262 22 and and CC cord-024189-t7mbsr25 1262 23 even even RB cord-024189-t7mbsr25 1262 24 coronary coronary JJ cord-024189-t7mbsr25 1262 25 angiography angiography NN cord-024189-t7mbsr25 1262 26 . . . cord-024189-t7mbsr25 1263 1 Electron electron NN cord-024189-t7mbsr25 1263 2 microscopy microscopy NN cord-024189-t7mbsr25 1263 3 studies study NNS cord-024189-t7mbsr25 1263 4 of of IN cord-024189-t7mbsr25 1263 5 endomyocardial endomyocardial JJ cord-024189-t7mbsr25 1263 6 biopsies biopsy NNS cord-024189-t7mbsr25 1263 7 up up IN cord-024189-t7mbsr25 1263 8 to to TO cord-024189-t7mbsr25 1263 9 23 23 CD cord-024189-t7mbsr25 1263 10 years year NNS cord-024189-t7mbsr25 1263 11 after after IN cord-024189-t7mbsr25 1263 12 the the DT cord-024189-t7mbsr25 1263 13 KD KD NNP cord-024189-t7mbsr25 1263 14 episode episode NN cord-024189-t7mbsr25 1263 15 showed show VBD cord-024189-t7mbsr25 1263 16 ongoing ongoing JJ cord-024189-t7mbsr25 1263 17 microaneurysms microaneurysm NNS cord-024189-t7mbsr25 1263 18 and and CC cord-024189-t7mbsr25 1263 19 small small JJ cord-024189-t7mbsr25 1263 20 vessel vessel NN cord-024189-t7mbsr25 1263 21 coagulopathy coagulopathy NN cord-024189-t7mbsr25 1263 22 . . . cord-024189-t7mbsr25 1264 1 In in IN cord-024189-t7mbsr25 1264 2 a a DT cord-024189-t7mbsr25 1264 3 small small JJ cord-024189-t7mbsr25 1264 4 number number NN cord-024189-t7mbsr25 1264 5 of of IN cord-024189-t7mbsr25 1264 6 young young JJ cord-024189-t7mbsr25 1264 7 adults adult NNS cord-024189-t7mbsr25 1264 8 who who WP cord-024189-t7mbsr25 1264 9 have have VBP cord-024189-t7mbsr25 1264 10 experienced experience VBN cord-024189-t7mbsr25 1264 11 myocardial myocardial JJ cord-024189-t7mbsr25 1264 12 infarctions infarction NNS cord-024189-t7mbsr25 1264 13 in in IN cord-024189-t7mbsr25 1264 14 the the DT cord-024189-t7mbsr25 1264 15 absence absence NN cord-024189-t7mbsr25 1264 16 of of IN cord-024189-t7mbsr25 1264 17 known know VBN cord-024189-t7mbsr25 1264 18 cardiac cardiac JJ cord-024189-t7mbsr25 1264 19 risk risk NN cord-024189-t7mbsr25 1264 20 factors factor NNS cord-024189-t7mbsr25 1264 21 , , , cord-024189-t7mbsr25 1264 22 angiograms angiogram NNS cord-024189-t7mbsr25 1264 23 have have VBP cord-024189-t7mbsr25 1264 24 revealed reveal VBN cord-024189-t7mbsr25 1264 25 giant giant JJ cord-024189-t7mbsr25 1264 26 coronary coronary JJ cord-024189-t7mbsr25 1264 27 artery artery NN cord-024189-t7mbsr25 1264 28 aneurysms aneurysm NNS cord-024189-t7mbsr25 1264 29 compatible compatible JJ cord-024189-t7mbsr25 1264 30 with with IN cord-024189-t7mbsr25 1264 31 old old JJ cord-024189-t7mbsr25 1264 32 KD KD NNP cord-024189-t7mbsr25 1264 33 . . . cord-024189-t7mbsr25 1265 1 The the DT cord-024189-t7mbsr25 1265 2 extent extent NN cord-024189-t7mbsr25 1265 3 of of IN cord-024189-t7mbsr25 1265 4 active active JJ cord-024189-t7mbsr25 1265 5 KD KD NNP cord-024189-t7mbsr25 1265 6 in in IN cord-024189-t7mbsr25 1265 7 such such JJ cord-024189-t7mbsr25 1265 8 patients patient NNS cord-024189-t7mbsr25 1265 9 , , , cord-024189-t7mbsr25 1265 10 if if IN cord-024189-t7mbsr25 1265 11 any any DT cord-024189-t7mbsr25 1265 12 , , , cord-024189-t7mbsr25 1265 13 as as IN cord-024189-t7mbsr25 1265 14 opposed oppose VBN cord-024189-t7mbsr25 1265 15 to to IN cord-024189-t7mbsr25 1265 16 the the DT cord-024189-t7mbsr25 1265 17 clinical clinical JJ cord-024189-t7mbsr25 1265 18 sequelae sequela NNS cord-024189-t7mbsr25 1265 19 occurring occur VBG cord-024189-t7mbsr25 1265 20 in in IN cord-024189-t7mbsr25 1265 21 arteries artery NNS cord-024189-t7mbsr25 1265 22 damaged damage VBN cord-024189-t7mbsr25 1265 23 years year NNS cord-024189-t7mbsr25 1265 24 before before RB cord-024189-t7mbsr25 1265 25 , , , cord-024189-t7mbsr25 1265 26 is be VBZ cord-024189-t7mbsr25 1265 27 not not RB cord-024189-t7mbsr25 1265 28 clear clear JJ cord-024189-t7mbsr25 1265 29 . . . cord-024189-t7mbsr25 1266 1 Newer new JJR cord-024189-t7mbsr25 1266 2 treatment treatment NN cord-024189-t7mbsr25 1266 3 modalities modality NNS cord-024189-t7mbsr25 1266 4 have have VBP cord-024189-t7mbsr25 1266 5 been be VBN cord-024189-t7mbsr25 1266 6 utilized utilize VBN cord-024189-t7mbsr25 1266 7 in in IN cord-024189-t7mbsr25 1266 8 selected select VBN cord-024189-t7mbsr25 1266 9 patients patient NNS cord-024189-t7mbsr25 1266 10 and and CC cord-024189-t7mbsr25 1266 11 patient patient JJ cord-024189-t7mbsr25 1266 12 populations population NNS cord-024189-t7mbsr25 1266 13 . . . cord-024189-t7mbsr25 1267 1 Small small JJ cord-024189-t7mbsr25 1267 2 studies study NNS cord-024189-t7mbsr25 1267 3 and and CC cord-024189-t7mbsr25 1267 4 anecdotal anecdotal JJ cord-024189-t7mbsr25 1267 5 reports report NNS cord-024189-t7mbsr25 1267 6 of of IN cord-024189-t7mbsr25 1267 7 treatment treatment NN cord-024189-t7mbsr25 1267 8 with with IN cord-024189-t7mbsr25 1267 9 the the DT cord-024189-t7mbsr25 1267 10 antiglycoprotein antiglycoprotein NNP cord-024189-t7mbsr25 1267 11 IIb IIb NNP cord-024189-t7mbsr25 1267 12 / / SYM cord-024189-t7mbsr25 1267 13 IIIa IIIa NNP cord-024189-t7mbsr25 1267 14 monoclonal monoclonal JJ cord-024189-t7mbsr25 1267 15 antibody antibody NNP cord-024189-t7mbsr25 1267 16 ( ( -LRB- cord-024189-t7mbsr25 1267 17 abciximab abciximab NNP cord-024189-t7mbsr25 1267 18 ) ) -RRB- cord-024189-t7mbsr25 1267 19 or or CC cord-024189-t7mbsr25 1267 20 with with IN cord-024189-t7mbsr25 1267 21 low low JJ cord-024189-t7mbsr25 1267 22 - - HYPH cord-024189-t7mbsr25 1267 23 molecular molecular JJ cord-024189-t7mbsr25 1267 24 - - HYPH cord-024189-t7mbsr25 1267 25 weight weight NN cord-024189-t7mbsr25 1267 26 heparin heparin NN cord-024189-t7mbsr25 1267 27 have have VBP cord-024189-t7mbsr25 1267 28 suggested suggest VBN cord-024189-t7mbsr25 1267 29 more more RBR cord-024189-t7mbsr25 1267 30 rapid rapid JJ cord-024189-t7mbsr25 1267 31 regression regression NN cord-024189-t7mbsr25 1267 32 of of IN cord-024189-t7mbsr25 1267 33 aneurysms aneurysm NNS cord-024189-t7mbsr25 1267 34 and and CC cord-024189-t7mbsr25 1267 35 perhaps perhaps RB cord-024189-t7mbsr25 1267 36 endothelial endothelial JJ cord-024189-t7mbsr25 1267 37 cell cell NN cord-024189-t7mbsr25 1267 38 remodeling remodeling NN cord-024189-t7mbsr25 1267 39 . . . cord-024189-t7mbsr25 1268 1 Noninvasive noninvasive JJ cord-024189-t7mbsr25 1268 2 imaging imaging NN cord-024189-t7mbsr25 1268 3 modalities modality NNS cord-024189-t7mbsr25 1268 4 , , , cord-024189-t7mbsr25 1268 5 such such JJ cord-024189-t7mbsr25 1268 6 as as IN cord-024189-t7mbsr25 1268 7 magnetic magnetic JJ cord-024189-t7mbsr25 1268 8 resonance resonance NN cord-024189-t7mbsr25 1268 9 imaging imaging NN cord-024189-t7mbsr25 1268 10 studies study NNS cord-024189-t7mbsr25 1268 11 of of IN cord-024189-t7mbsr25 1268 12 the the DT cord-024189-t7mbsr25 1268 13 chest chest NN cord-024189-t7mbsr25 1268 14 and and CC cord-024189-t7mbsr25 1268 15 abdomen abdomen NN cord-024189-t7mbsr25 1268 16 , , , cord-024189-t7mbsr25 1268 17 have have VB cord-024189-t7mbsr25 1268 18 identifi identifi VBN cord-024189-t7mbsr25 1268 19 ed ed NN cord-024189-t7mbsr25 1269 1 the the DT cord-024189-t7mbsr25 1269 2 extracardiac extracardiac NNPS cord-024189-t7mbsr25 1269 3 arterial arterial JJ cord-024189-t7mbsr25 1269 4 aneurysms aneurysm NNS cord-024189-t7mbsr25 1269 5 and and CC cord-024189-t7mbsr25 1269 6 dilatation dilatation NN cord-024189-t7mbsr25 1269 7 ( ( -LRB- cord-024189-t7mbsr25 1269 8 Figure figure NN cord-024189-t7mbsr25 1269 9 21F-1 21f-1 CD cord-024189-t7mbsr25 1269 10 ) ) -RRB- cord-024189-t7mbsr25 1269 11 . . . cord-024189-t7mbsr25 1270 1 The the DT cord-024189-t7mbsr25 1270 2 knowledge knowledge NN cord-024189-t7mbsr25 1270 3 of of IN cord-024189-t7mbsr25 1270 4 the the DT cord-024189-t7mbsr25 1270 5 more more RBR cord-024189-t7mbsr25 1270 6 widespread widespread JJ cord-024189-t7mbsr25 1270 7 nature nature NN cord-024189-t7mbsr25 1270 8 of of IN cord-024189-t7mbsr25 1270 9 the the DT cord-024189-t7mbsr25 1270 10 vasculitic vasculitic JJ cord-024189-t7mbsr25 1270 11 involvement involvement NN cord-024189-t7mbsr25 1270 12 has have VBZ cord-024189-t7mbsr25 1270 13 prompted prompt VBN cord-024189-t7mbsr25 1270 14 more more RBR cord-024189-t7mbsr25 1270 15 aggressive aggressive JJ cord-024189-t7mbsr25 1270 16 and and CC cord-024189-t7mbsr25 1270 17 combination combination NN cord-024189-t7mbsr25 1270 18 therapies therapy NNS cord-024189-t7mbsr25 1270 19 ( ( -LRB- cord-024189-t7mbsr25 1270 20 39 39 CD cord-024189-t7mbsr25 1270 21 ) ) -RRB- cord-024189-t7mbsr25 1270 22 . . . cord-024189-t7mbsr25 1271 1 Pentoxifylline Pentoxifylline NNP cord-024189-t7mbsr25 1271 2 , , , cord-024189-t7mbsr25 1271 3 a a DT cord-024189-t7mbsr25 1271 4 phosphodiesterase phosphodiesterase NN cord-024189-t7mbsr25 1271 5 inhibitor inhibitor NN cord-024189-t7mbsr25 1271 6 , , , cord-024189-t7mbsr25 1271 7 has have VBZ cord-024189-t7mbsr25 1271 8 antiplatelet antiplatelet NN cord-024189-t7mbsr25 1271 9 activity activity NN cord-024189-t7mbsr25 1271 10 , , , cord-024189-t7mbsr25 1271 11 vasodilatory vasodilatory JJ cord-024189-t7mbsr25 1271 12 effects effect NNS cord-024189-t7mbsr25 1271 13 , , , cord-024189-t7mbsr25 1271 14 effects effect NNS cord-024189-t7mbsr25 1271 15 on on IN cord-024189-t7mbsr25 1271 16 red red JJ cord-024189-t7mbsr25 1271 17 blood blood NN cord-024189-t7mbsr25 1271 18 cell cell NN cord-024189-t7mbsr25 1271 19 rheology rheology NN cord-024189-t7mbsr25 1271 20 , , , cord-024189-t7mbsr25 1271 21 and and CC cord-024189-t7mbsr25 1271 22 the the DT cord-024189-t7mbsr25 1271 23 ability ability NN cord-024189-t7mbsr25 1271 24 to to TO cord-024189-t7mbsr25 1271 25 inhibit inhibit VB cord-024189-t7mbsr25 1271 26 TNF TNF NNP cord-024189-t7mbsr25 1271 27 synthesis synthesis NN cord-024189-t7mbsr25 1271 28 . . . cord-024189-t7mbsr25 1272 1 A a DT cord-024189-t7mbsr25 1272 2 regimen regimen NN cord-024189-t7mbsr25 1272 3 of of IN cord-024189-t7mbsr25 1272 4 20 20 CD cord-024189-t7mbsr25 1272 5 mg mg NNP cord-024189-t7mbsr25 1272 6 / / SYM cord-024189-t7mbsr25 1272 7 kg kg NNP cord-024189-t7mbsr25 1272 8 / / SYM cord-024189-t7mbsr25 1272 9 day day NN cord-024189-t7mbsr25 1272 10 of of IN cord-024189-t7mbsr25 1272 11 pentoxifylline pentoxifylline NN cord-024189-t7mbsr25 1272 12 in in IN cord-024189-t7mbsr25 1272 13 three three CD cord-024189-t7mbsr25 1272 14 divided divide VBN cord-024189-t7mbsr25 1272 15 doses dose NNS cord-024189-t7mbsr25 1272 16 demonstrated demonstrate VBD cord-024189-t7mbsr25 1272 17 an an DT cord-024189-t7mbsr25 1272 18 improvement improvement NN cord-024189-t7mbsr25 1272 19 in in IN cord-024189-t7mbsr25 1272 20 clinical clinical JJ cord-024189-t7mbsr25 1272 21 features feature NNS cord-024189-t7mbsr25 1272 22 and and CC cord-024189-t7mbsr25 1272 23 the the DT cord-024189-t7mbsr25 1272 24 rate rate NN cord-024189-t7mbsr25 1272 25 of of IN cord-024189-t7mbsr25 1272 26 aneurysm aneurysm NN cord-024189-t7mbsr25 1272 27 formation formation NN cord-024189-t7mbsr25 1272 28 in in IN cord-024189-t7mbsr25 1272 29 KD KD NNP cord-024189-t7mbsr25 1272 30 ( ( -LRB- cord-024189-t7mbsr25 1272 31 40 40 CD cord-024189-t7mbsr25 1272 32 ) ) -RRB- cord-024189-t7mbsr25 1272 33 . . . cord-024189-t7mbsr25 1273 1 Further further JJ cord-024189-t7mbsr25 1273 2 pharmacokinetic pharmacokinetic JJ cord-024189-t7mbsr25 1273 3 studies study NNS cord-024189-t7mbsr25 1273 4 of of IN cord-024189-t7mbsr25 1273 5 a a DT cord-024189-t7mbsr25 1273 6 commercial commercial JJ cord-024189-t7mbsr25 1273 7 liquid liquid NN cord-024189-t7mbsr25 1273 8 preparation preparation NN cord-024189-t7mbsr25 1273 9 of of IN cord-024189-t7mbsr25 1273 10 pentoxifylline pentoxifylline NNP cord-024189-t7mbsr25 1273 11 demonstrated demonstrate VBD cord-024189-t7mbsr25 1273 12 safety safety NN cord-024189-t7mbsr25 1273 13 and and CC cord-024189-t7mbsr25 1273 14 a a DT cord-024189-t7mbsr25 1273 15 reduction reduction NN cord-024189-t7mbsr25 1273 16 in in IN cord-024189-t7mbsr25 1273 17 TNF TNF NNP cord-024189-t7mbsr25 1273 18 levels level NNS cord-024189-t7mbsr25 1273 19 in in IN cord-024189-t7mbsr25 1273 20 KD KD NNP cord-024189-t7mbsr25 1273 21 patients patient NNS cord-024189-t7mbsr25 1273 22 of of IN cord-024189-t7mbsr25 1273 23 28 28 CD cord-024189-t7mbsr25 1273 24 % % NN cord-024189-t7mbsr25 1273 25 with with IN cord-024189-t7mbsr25 1273 26 doses dose NNS cord-024189-t7mbsr25 1273 27 up up IN cord-024189-t7mbsr25 1273 28 to to TO cord-024189-t7mbsr25 1273 29 25 25 CD cord-024189-t7mbsr25 1273 30 mg mg NNP cord-024189-t7mbsr25 1273 31 / / SYM cord-024189-t7mbsr25 1273 32 kg kg NNP cord-024189-t7mbsr25 1273 33 / / SYM cord-024189-t7mbsr25 1273 34 day day NN cord-024189-t7mbsr25 1273 35 ( ( -LRB- cord-024189-t7mbsr25 1273 36 41 41 CD cord-024189-t7mbsr25 1273 37 ) ) -RRB- cord-024189-t7mbsr25 1273 38 . . . cord-024189-t7mbsr25 1274 1 Anecdotal anecdotal JJ cord-024189-t7mbsr25 1274 2 reports report NNS cord-024189-t7mbsr25 1274 3 indicate indicate VBP cord-024189-t7mbsr25 1274 4 tolerability tolerability NN cord-024189-t7mbsr25 1274 5 of of IN cord-024189-t7mbsr25 1274 6 doses dose NNS cord-024189-t7mbsr25 1274 7 of of IN cord-024189-t7mbsr25 1274 8 40 40 CD cord-024189-t7mbsr25 1274 9 to to TO cord-024189-t7mbsr25 1274 10 60 60 CD cord-024189-t7mbsr25 1274 11 mg mg NNP cord-024189-t7mbsr25 1274 12 / / SYM cord-024189-t7mbsr25 1274 13 kg kg NNP cord-024189-t7mbsr25 1274 14 / / SYM cord-024189-t7mbsr25 1274 15 day day NN cord-024189-t7mbsr25 1274 16 in in IN cord-024189-t7mbsr25 1274 17 infants infant NNS cord-024189-t7mbsr25 1274 18 with with IN cord-024189-t7mbsr25 1274 19 KD KD NNP cord-024189-t7mbsr25 1274 20 . . . cord-024189-t7mbsr25 1275 1 A a DT cord-024189-t7mbsr25 1275 2 multicenter multicenter JJ cord-024189-t7mbsr25 1275 3 trial trial NN cord-024189-t7mbsr25 1275 4 of of IN cord-024189-t7mbsr25 1275 5 infl infl NNP cord-024189-t7mbsr25 1275 6 iximab iximab NNS cord-024189-t7mbsr25 1275 7 in in IN cord-024189-t7mbsr25 1275 8 KD KD NNP cord-024189-t7mbsr25 1275 9 is be VBZ cord-024189-t7mbsr25 1275 10 currently currently RB cord-024189-t7mbsr25 1275 11 under under IN cord-024189-t7mbsr25 1275 12 way way NN cord-024189-t7mbsr25 1275 13 ( ( -LRB- cord-024189-t7mbsr25 1275 14 42 42 CD cord-024189-t7mbsr25 1275 15 , , , cord-024189-t7mbsr25 1275 16 43 43 CD cord-024189-t7mbsr25 1275 17 ) ) -RRB- cord-024189-t7mbsr25 1275 18 . . . cord-024189-t7mbsr25 1276 1 Giant giant JJ cord-024189-t7mbsr25 1276 2 cell cell NN cord-024189-t7mbsr25 1276 3 arteritis arteritis NN cord-024189-t7mbsr25 1276 4 and and CC cord-024189-t7mbsr25 1276 5 polymyalgia polymyalgia NNP cord-024189-t7mbsr25 1276 6 rheumatica rheumatica NNP cord-024189-t7mbsr25 1276 7 Medium Medium NNP cord-024189-t7mbsr25 1276 8 - - : cord-024189-t7mbsr25 1276 9 and and CC cord-024189-t7mbsr25 1276 10 large large JJ cord-024189-t7mbsr25 1276 11 - - HYPH cord-024189-t7mbsr25 1276 12 vessel vessel NN cord-024189-t7mbsr25 1276 13 vasculitis vasculitis NN cord-024189-t7mbsr25 1276 14 Activation activation NN cord-024189-t7mbsr25 1276 15 of of IN cord-024189-t7mbsr25 1276 16 arterial arterial JJ cord-024189-t7mbsr25 1276 17 wall wall NN cord-024189-t7mbsr25 1276 18 dendritic dendritic JJ cord-024189-t7mbsr25 1276 19 cells cell NNS cord-024189-t7mbsr25 1276 20 and and CC cord-024189-t7mbsr25 1276 21 breakdown breakdown NN cord-024189-t7mbsr25 1276 22 of of IN cord-024189-t7mbsr25 1276 23 self self NN cord-024189-t7mbsr25 1276 24 - - HYPH cord-024189-t7mbsr25 1276 25 tolerance tolerance NN cord-024189-t7mbsr25 1276 26 in in IN cord-024189-t7mbsr25 1276 27 giant giant JJ cord-024189-t7mbsr25 1276 28 cell cell NN cord-024189-t7mbsr25 1276 29 arteritis arteritis NN cord-024189-t7mbsr25 1276 30 Correlation correlation NN cord-024189-t7mbsr25 1276 31 of of IN cord-024189-t7mbsr25 1276 32 the the DT cord-024189-t7mbsr25 1276 33 topographical topographical JJ cord-024189-t7mbsr25 1276 34 arrangement arrangement NN cord-024189-t7mbsr25 1276 35 and and CC cord-024189-t7mbsr25 1276 36 the the DT cord-024189-t7mbsr25 1276 37 functional functional JJ cord-024189-t7mbsr25 1276 38 pattern pattern NN cord-024189-t7mbsr25 1276 39 of of IN cord-024189-t7mbsr25 1276 40 tissue tissue NN cord-024189-t7mbsr25 1276 41 - - HYPH cord-024189-t7mbsr25 1276 42 infi infi NNP cord-024189-t7mbsr25 1276 43 ltrating ltrating NN cord-024189-t7mbsr25 1276 44 macrophages macrophage NNS cord-024189-t7mbsr25 1276 45 in in IN cord-024189-t7mbsr25 1276 46 giant giant JJ cord-024189-t7mbsr25 1276 47 cell cell NN cord-024189-t7mbsr25 1276 48 arteritis arteritis NN cord-024189-t7mbsr25 1276 49 Tissue tissue NN cord-024189-t7mbsr25 1276 50 - - HYPH cord-024189-t7mbsr25 1276 51 destructive destructive JJ cord-024189-t7mbsr25 1276 52 macrophages macrophage NNS cord-024189-t7mbsr25 1276 53 in in IN cord-024189-t7mbsr25 1276 54 giant giant JJ cord-024189-t7mbsr25 1276 55 cell cell NN cord-024189-t7mbsr25 1276 56 arteritis arteritis NN cord-024189-t7mbsr25 1276 57 Disease Disease NNP cord-024189-t7mbsr25 1276 58 patterns pattern NNS cord-024189-t7mbsr25 1276 59 and and CC cord-024189-t7mbsr25 1276 60 tissue tissue NN cord-024189-t7mbsr25 1276 61 cytokine cytokine NN cord-024189-t7mbsr25 1276 62 profi profi FW cord-024189-t7mbsr25 1276 63 les les NNP cord-024189-t7mbsr25 1276 64 in in IN cord-024189-t7mbsr25 1276 65 giant giant JJ cord-024189-t7mbsr25 1276 66 cell cell NN cord-024189-t7mbsr25 1276 67 arteritis arteritis NN cord-024189-t7mbsr25 1276 68 Arterial arterial JJ cord-024189-t7mbsr25 1276 69 wall wall NN cord-024189-t7mbsr25 1276 70 injury injury NN cord-024189-t7mbsr25 1276 71 in in IN cord-024189-t7mbsr25 1276 72 giant giant JJ cord-024189-t7mbsr25 1276 73 cell cell NN cord-024189-t7mbsr25 1276 74 arteritis arteritis NN cord-024189-t7mbsr25 1276 75 Platelet platelet NN cord-024189-t7mbsr25 1276 76 - - HYPH cord-024189-t7mbsr25 1276 77 derived derive VBN cord-024189-t7mbsr25 1276 78 growth growth NN cord-024189-t7mbsr25 1276 79 factor factor NN cord-024189-t7mbsr25 1276 80 , , , cord-024189-t7mbsr25 1276 81 intimal intimal JJ cord-024189-t7mbsr25 1276 82 hyperplasia hyperplasia NN cord-024189-t7mbsr25 1276 83 , , , cord-024189-t7mbsr25 1276 84 and and CC cord-024189-t7mbsr25 1276 85 ischemic ischemic JJ cord-024189-t7mbsr25 1276 86 complications complication NNS cord-024189-t7mbsr25 1276 87 in in IN cord-024189-t7mbsr25 1276 88 giant giant JJ cord-024189-t7mbsr25 1276 89 cell cell NN cord-024189-t7mbsr25 1276 90 arteritis arteritis NN cord-024189-t7mbsr25 1276 91 Formation Formation NNP cord-024189-t7mbsr25 1276 92 of of IN cord-024189-t7mbsr25 1276 93 new new JJ cord-024189-t7mbsr25 1276 94 vasa vasa NNP cord-024189-t7mbsr25 1276 95 vasorum vasorum NNP cord-024189-t7mbsr25 1276 96 in in IN cord-024189-t7mbsr25 1276 97 vasculitis vasculitis NN cord-024189-t7mbsr25 1276 98 . . . cord-024189-t7mbsr25 1277 1 Production production NN cord-024189-t7mbsr25 1277 2 of of IN cord-024189-t7mbsr25 1277 3 angiogenic angiogenic JJ cord-024189-t7mbsr25 1277 4 cytokines cytokine NNS cord-024189-t7mbsr25 1277 5 by by IN cord-024189-t7mbsr25 1277 6 multinucleated multinucleate VBN cord-024189-t7mbsr25 1277 7 giant giant JJ cord-024189-t7mbsr25 1277 8 cells cell NNS cord-024189-t7mbsr25 1278 1 Aldose Aldose NNP cord-024189-t7mbsr25 1278 2 reductase reductase NN cord-024189-t7mbsr25 1278 3 functions function NNS cord-024189-t7mbsr25 1278 4 as as IN cord-024189-t7mbsr25 1278 5 a a DT cord-024189-t7mbsr25 1278 6 detoxifi detoxifi NNP cord-024189-t7mbsr25 1278 7 cation cation NN cord-024189-t7mbsr25 1278 8 system system NN cord-024189-t7mbsr25 1278 9 for for IN cord-024189-t7mbsr25 1278 10 lipid lipid NN cord-024189-t7mbsr25 1278 11 peroxidation peroxidation NN cord-024189-t7mbsr25 1278 12 products product NNS cord-024189-t7mbsr25 1278 13 in in IN cord-024189-t7mbsr25 1278 14 vasculitis vasculitis JJ cord-024189-t7mbsr25 1278 15 Giant giant JJ cord-024189-t7mbsr25 1278 16 - - HYPH cord-024189-t7mbsr25 1278 17 cell cell NN cord-024189-t7mbsr25 1278 18 arteritis arteritis NN cord-024189-t7mbsr25 1278 19 and and CC cord-024189-t7mbsr25 1278 20 polymyalgia polymyalgia NNP cord-024189-t7mbsr25 1278 21 rheumatica rheumatica NNP cord-024189-t7mbsr25 1278 22 Disease Disease NNP cord-024189-t7mbsr25 1278 23 pattern pattern NN cord-024189-t7mbsr25 1278 24 in in IN cord-024189-t7mbsr25 1278 25 cranial cranial JJ cord-024189-t7mbsr25 1278 26 and and CC cord-024189-t7mbsr25 1278 27 large large JJ cord-024189-t7mbsr25 1278 28 - - HYPH cord-024189-t7mbsr25 1278 29 vessel vessel NN cord-024189-t7mbsr25 1278 30 giant giant JJ cord-024189-t7mbsr25 1278 31 cell cell NN cord-024189-t7mbsr25 1278 32 arteritis arteritis NN cord-024189-t7mbsr25 1278 33 Incidence incidence NN cord-024189-t7mbsr25 1278 34 and and CC cord-024189-t7mbsr25 1278 35 predictors predictor NNS cord-024189-t7mbsr25 1278 36 of of IN cord-024189-t7mbsr25 1278 37 large large JJ cord-024189-t7mbsr25 1278 38 - - HYPH cord-024189-t7mbsr25 1278 39 artery artery NN cord-024189-t7mbsr25 1278 40 complication complication NN cord-024189-t7mbsr25 1278 41 ( ( -LRB- cord-024189-t7mbsr25 1278 42 aortic aortic JJ cord-024189-t7mbsr25 1278 43 aneurysm aneurysm NN cord-024189-t7mbsr25 1278 44 , , , cord-024189-t7mbsr25 1278 45 aortic aortic JJ cord-024189-t7mbsr25 1278 46 dissection dissection NN cord-024189-t7mbsr25 1278 47 , , , cord-024189-t7mbsr25 1278 48 and/or and/or CC cord-024189-t7mbsr25 1278 49 large large JJ cord-024189-t7mbsr25 1278 50 - - HYPH cord-024189-t7mbsr25 1278 51 artery artery NN cord-024189-t7mbsr25 1278 52 stenosis stenosis NN cord-024189-t7mbsr25 1278 53 ) ) -RRB- cord-024189-t7mbsr25 1278 54 in in IN cord-024189-t7mbsr25 1278 55 patients patient NNS cord-024189-t7mbsr25 1278 56 with with IN cord-024189-t7mbsr25 1278 57 giant giant JJ cord-024189-t7mbsr25 1278 58 cell cell NN cord-024189-t7mbsr25 1278 59 arteritis arteritis NN cord-024189-t7mbsr25 1278 60 : : : cord-024189-t7mbsr25 1278 61 a a DT cord-024189-t7mbsr25 1278 62 populationbased populationbased JJ cord-024189-t7mbsr25 1278 63 study study NN cord-024189-t7mbsr25 1278 64 over over IN cord-024189-t7mbsr25 1278 65 50 50 CD cord-024189-t7mbsr25 1278 66 years year NNS cord-024189-t7mbsr25 1278 67 Increased increase VBN cord-024189-t7mbsr25 1278 68 incidence incidence NN cord-024189-t7mbsr25 1278 69 of of IN cord-024189-t7mbsr25 1278 70 aortic aortic JJ cord-024189-t7mbsr25 1278 71 aneurysm aneurysm NN cord-024189-t7mbsr25 1278 72 and and CC cord-024189-t7mbsr25 1278 73 dissection dissection NN cord-024189-t7mbsr25 1278 74 in in IN cord-024189-t7mbsr25 1278 75 giant giant JJ cord-024189-t7mbsr25 1278 76 cell cell NN cord-024189-t7mbsr25 1278 77 ( ( -LRB- cord-024189-t7mbsr25 1278 78 temporal temporal JJ cord-024189-t7mbsr25 1278 79 ) ) -RRB- cord-024189-t7mbsr25 1278 80 arteritis arteritis NN cord-024189-t7mbsr25 1278 81 . . . cord-024189-t7mbsr25 1279 1 A a DT cord-024189-t7mbsr25 1279 2 population population NN cord-024189-t7mbsr25 1279 3 - - HYPH cord-024189-t7mbsr25 1279 4 based base VBN cord-024189-t7mbsr25 1279 5 study study NN cord-024189-t7mbsr25 1279 6 Does do VBZ cord-024189-t7mbsr25 1279 7 this this DT cord-024189-t7mbsr25 1279 8 patient patient NN cord-024189-t7mbsr25 1279 9 have have VB cord-024189-t7mbsr25 1279 10 temporal temporal JJ cord-024189-t7mbsr25 1279 11 arteritis arteritis NN cord-024189-t7mbsr25 1279 12 ? ? . cord-024189-t7mbsr25 1280 1 Treatment treatment NN cord-024189-t7mbsr25 1280 2 of of IN cord-024189-t7mbsr25 1280 3 giant giant JJ cord-024189-t7mbsr25 1280 4 cell cell NN cord-024189-t7mbsr25 1280 5 arteritis arteritis NN cord-024189-t7mbsr25 1280 6 : : : cord-024189-t7mbsr25 1280 7 interleukin-6 interleukin-6 RB cord-024189-t7mbsr25 1280 8 as as IN cord-024189-t7mbsr25 1280 9 a a DT cord-024189-t7mbsr25 1280 10 biologic biologic JJ cord-024189-t7mbsr25 1280 11 marker marker NN cord-024189-t7mbsr25 1280 12 of of IN cord-024189-t7mbsr25 1280 13 disease disease NN cord-024189-t7mbsr25 1280 14 activity activity NN cord-024189-t7mbsr25 1280 15 Large large JJ cord-024189-t7mbsr25 1280 16 - - HYPH cord-024189-t7mbsr25 1280 17 vessel vessel NN cord-024189-t7mbsr25 1280 18 vasculitis vasculitis NN cord-024189-t7mbsr25 1280 19 Is be VBZ cord-024189-t7mbsr25 1280 20 duplex duplex NN cord-024189-t7mbsr25 1280 21 ultrasonography ultrasonography NN cord-024189-t7mbsr25 1280 22 useful useful JJ cord-024189-t7mbsr25 1280 23 for for IN cord-024189-t7mbsr25 1280 24 the the DT cord-024189-t7mbsr25 1280 25 diagnosis diagnosis NN cord-024189-t7mbsr25 1280 26 of of IN cord-024189-t7mbsr25 1280 27 giant giant JJ cord-024189-t7mbsr25 1280 28 - - HYPH cord-024189-t7mbsr25 1280 29 cell cell NN cord-024189-t7mbsr25 1280 30 arteritis arteritis NN cord-024189-t7mbsr25 1280 31 ? ? . cord-024189-t7mbsr25 1281 1 Visual visual JJ cord-024189-t7mbsr25 1281 2 improvement improvement NN cord-024189-t7mbsr25 1281 3 with with IN cord-024189-t7mbsr25 1281 4 corticosteroid corticosteroid NN cord-024189-t7mbsr25 1281 5 therapy therapy NN cord-024189-t7mbsr25 1281 6 in in IN cord-024189-t7mbsr25 1281 7 giant giant JJ cord-024189-t7mbsr25 1281 8 cell cell NN cord-024189-t7mbsr25 1281 9 arteritis arteritis NN cord-024189-t7mbsr25 1282 1 A a DT cord-024189-t7mbsr25 1282 2 multicenter multicenter JJ cord-024189-t7mbsr25 1282 3 placebo placebo NN cord-024189-t7mbsr25 1282 4 - - HYPH cord-024189-t7mbsr25 1282 5 controlled control VBN cord-024189-t7mbsr25 1282 6 study study NN cord-024189-t7mbsr25 1282 7 of of IN cord-024189-t7mbsr25 1282 8 methotrexate methotrexate NNP cord-024189-t7mbsr25 1282 9 ( ( -LRB- cord-024189-t7mbsr25 1282 10 MTX MTX NNP cord-024189-t7mbsr25 1282 11 ) ) -RRB- cord-024189-t7mbsr25 1282 12 in in IN cord-024189-t7mbsr25 1282 13 giant giant JJ cord-024189-t7mbsr25 1282 14 cell cell NN cord-024189-t7mbsr25 1282 15 ateritis ateritis NN cord-024189-t7mbsr25 1282 16 ( ( -LRB- cord-024189-t7mbsr25 1282 17 GCA GCA NNP cord-024189-t7mbsr25 1282 18 ) ) -RRB- cord-024189-t7mbsr25 1282 19 Prednisone Prednisone NNP cord-024189-t7mbsr25 1282 20 and and CC cord-024189-t7mbsr25 1282 21 infl infl NNP cord-024189-t7mbsr25 1282 22 iximab iximab NNS cord-024189-t7mbsr25 1282 23 for for IN cord-024189-t7mbsr25 1282 24 giant giant JJ cord-024189-t7mbsr25 1282 25 cell cell NN cord-024189-t7mbsr25 1282 26 arteritis arteritis NN cord-024189-t7mbsr25 1282 27 : : : cord-024189-t7mbsr25 1282 28 a a DT cord-024189-t7mbsr25 1282 29 randomized randomized JJ cord-024189-t7mbsr25 1282 30 , , , cord-024189-t7mbsr25 1282 31 double double JJ cord-024189-t7mbsr25 1282 32 - - HYPH cord-024189-t7mbsr25 1282 33 blind blind JJ cord-024189-t7mbsr25 1282 34 , , , cord-024189-t7mbsr25 1282 35 placebo placebo NN cord-024189-t7mbsr25 1282 36 - - HYPH cord-024189-t7mbsr25 1282 37 controlled control VBN cord-024189-t7mbsr25 1282 38 , , , cord-024189-t7mbsr25 1282 39 multicenter multicenter JJ cord-024189-t7mbsr25 1282 40 study study NN cord-024189-t7mbsr25 1282 41 of of IN cord-024189-t7mbsr25 1282 42 effi effi NNP cord-024189-t7mbsr25 1282 43 cacy cacy NNP cord-024189-t7mbsr25 1282 44 and and CC cord-024189-t7mbsr25 1282 45 safety safety NN cord-024189-t7mbsr25 1282 46 Treatment Treatment NNP cord-024189-t7mbsr25 1282 47 of of IN cord-024189-t7mbsr25 1282 48 giant giant JJ cord-024189-t7mbsr25 1282 49 cell cell NN cord-024189-t7mbsr25 1282 50 arteritis arteritis NN cord-024189-t7mbsr25 1282 51 : : : cord-024189-t7mbsr25 1283 1 induction induction NN cord-024189-t7mbsr25 1283 2 therapy therapy NN cord-024189-t7mbsr25 1283 3 with with IN cord-024189-t7mbsr25 1283 4 high high JJ cord-024189-t7mbsr25 1283 5 dose dose NN cord-024189-t7mbsr25 1283 6 glucocorticoids glucocorticoid NNS cord-024189-t7mbsr25 1283 7 Low low JJ cord-024189-t7mbsr25 1283 8 - - HYPH cord-024189-t7mbsr25 1283 9 dose dose NN cord-024189-t7mbsr25 1283 10 aspirin aspirin NN cord-024189-t7mbsr25 1283 11 and and CC cord-024189-t7mbsr25 1283 12 prevention prevention NN cord-024189-t7mbsr25 1283 13 of of IN cord-024189-t7mbsr25 1283 14 cranial cranial JJ cord-024189-t7mbsr25 1283 15 ischemic ischemic JJ cord-024189-t7mbsr25 1283 16 complications complication NNS cord-024189-t7mbsr25 1283 17 in in IN cord-024189-t7mbsr25 1283 18 giant giant JJ cord-024189-t7mbsr25 1283 19 cell cell NN cord-024189-t7mbsr25 1283 20 arteritis arteritis NN cord-024189-t7mbsr25 1283 21 Polymyalgia Polymyalgia NNP cord-024189-t7mbsr25 1283 22 rheumatica rheumatica NNP cord-024189-t7mbsr25 1283 23 and and CC cord-024189-t7mbsr25 1283 24 giant giant JJ cord-024189-t7mbsr25 1283 25 - - HYPH cord-024189-t7mbsr25 1283 26 cell cell NN cord-024189-t7mbsr25 1283 27 arteritis arteritis NN cord-024189-t7mbsr25 1283 28 Tissue tissue NN cord-024189-t7mbsr25 1283 29 cytokine cytokine NN cord-024189-t7mbsr25 1283 30 patterns pattern NNS cord-024189-t7mbsr25 1283 31 in in IN cord-024189-t7mbsr25 1283 32 patients patient NNS cord-024189-t7mbsr25 1283 33 with with IN cord-024189-t7mbsr25 1283 34 polymyalgia polymyalgia NNP cord-024189-t7mbsr25 1283 35 rheumatica rheumatica NNP cord-024189-t7mbsr25 1283 36 and and CC cord-024189-t7mbsr25 1283 37 giant giant JJ cord-024189-t7mbsr25 1283 38 cell cell NN cord-024189-t7mbsr25 1283 39 arteritis arteritis NN cord-024189-t7mbsr25 1283 40 Corticosteroid Corticosteroid NNP cord-024189-t7mbsr25 1283 41 requirements requirement NNS cord-024189-t7mbsr25 1283 42 in in IN cord-024189-t7mbsr25 1283 43 polymyalgia polymyalgia NN cord-024189-t7mbsr25 1283 44 rheumatica rheumatica NNP cord-024189-t7mbsr25 1283 45 Proximal Proximal NNP cord-024189-t7mbsr25 1283 46 bursitis bursitis NN cord-024189-t7mbsr25 1283 47 in in IN cord-024189-t7mbsr25 1283 48 active active JJ cord-024189-t7mbsr25 1283 49 polymyalgia polymyalgia NN cord-024189-t7mbsr25 1283 50 rheumatica rheumatica NNP cord-024189-t7mbsr25 1284 1 Takayasu Takayasu NNP cord-024189-t7mbsr25 1284 2 's 's POS cord-024189-t7mbsr25 1284 3 arteritis arteritis NN cord-024189-t7mbsr25 1284 4 Differences difference NNS cord-024189-t7mbsr25 1284 5 in in IN cord-024189-t7mbsr25 1284 6 clinical clinical JJ cord-024189-t7mbsr25 1284 7 presentation presentation NN cord-024189-t7mbsr25 1284 8 and and CC cord-024189-t7mbsr25 1284 9 outcome outcome NN cord-024189-t7mbsr25 1284 10 in in IN cord-024189-t7mbsr25 1284 11 different different JJ cord-024189-t7mbsr25 1284 12 countries country NNS cord-024189-t7mbsr25 1284 13 for for IN cord-024189-t7mbsr25 1284 14 Takayasu Takayasu NNP cord-024189-t7mbsr25 1284 15 's 's POS cord-024189-t7mbsr25 1284 16 arteritis arteritis NN cord-024189-t7mbsr25 1284 17 Takayasu Takayasu NNP cord-024189-t7mbsr25 1284 18 arteritis arteritis NN cord-024189-t7mbsr25 1284 19 : : : cord-024189-t7mbsr25 1284 20 insights insight NNS cord-024189-t7mbsr25 1284 21 into into IN cord-024189-t7mbsr25 1284 22 immunopathology immunopathology VBG cord-024189-t7mbsr25 1284 23 Comprehensive comprehensive JJ cord-024189-t7mbsr25 1284 24 analysis analysis NN cord-024189-t7mbsr25 1284 25 of of IN cord-024189-t7mbsr25 1284 26 HLA HLA NNP cord-024189-t7mbsr25 1284 27 genes gene NNS cord-024189-t7mbsr25 1284 28 in in IN cord-024189-t7mbsr25 1284 29 Takayasu Takayasu NNP cord-024189-t7mbsr25 1284 30 arteritis arteritis NN cord-024189-t7mbsr25 1284 31 in in IN cord-024189-t7mbsr25 1284 32 Japan Japan NNP cord-024189-t7mbsr25 1284 33 Diagnostic Diagnostic NNP cord-024189-t7mbsr25 1284 34 imaging imaging NN cord-024189-t7mbsr25 1284 35 in in IN cord-024189-t7mbsr25 1284 36 Takayasu Takayasu NNP cord-024189-t7mbsr25 1284 37 arteritis arteritis NN cord-024189-t7mbsr25 1284 38 Advances advance VBZ cord-024189-t7mbsr25 1284 39 in in IN cord-024189-t7mbsr25 1284 40 the the DT cord-024189-t7mbsr25 1284 41 medical medical JJ cord-024189-t7mbsr25 1284 42 and and CC cord-024189-t7mbsr25 1284 43 surgical surgical JJ cord-024189-t7mbsr25 1284 44 treatment treatment NN cord-024189-t7mbsr25 1284 45 of of IN cord-024189-t7mbsr25 1284 46 Takayasu Takayasu NNP cord-024189-t7mbsr25 1284 47 arteritis arteritis NN cord-024189-t7mbsr25 1284 48 Takayasu Takayasu NNP cord-024189-t7mbsr25 1284 49 arteritis arteritis NN cord-024189-t7mbsr25 1284 50 Methotrexate Methotrexate NNP cord-024189-t7mbsr25 1284 51 use use VBP cord-024189-t7mbsr25 1284 52 in in IN cord-024189-t7mbsr25 1284 53 systemic systemic JJ cord-024189-t7mbsr25 1284 54 vasculitis vasculitis NN cord-024189-t7mbsr25 1284 55 Ueber Ueber NNP cord-024189-t7mbsr25 1284 56 eine eine NNP cord-024189-t7mbsr25 1284 57 bisher bisher NNP cord-024189-t7mbsr25 1284 58 nicht nicht NNP cord-024189-t7mbsr25 1284 59 beschriebene beschriebene NNP cord-024189-t7mbsr25 1284 60 eigenthumliche eigenthumliche NNP cord-024189-t7mbsr25 1284 61 arterienerkrankung arterienerkrankung NNP cord-024189-t7mbsr25 1284 62 ( ( -LRB- cord-024189-t7mbsr25 1284 63 periarteritis periarteritis NNP cord-024189-t7mbsr25 1284 64 nodosa nodosa NNP cord-024189-t7mbsr25 1284 65 ) ) -RRB- cord-024189-t7mbsr25 1285 1 , , , cord-024189-t7mbsr25 1285 2 die die VB cord-024189-t7mbsr25 1285 3 mit mit NNP cord-024189-t7mbsr25 1285 4 morbus morbus NNP cord-024189-t7mbsr25 1285 5 brightii brightii NNP cord-024189-t7mbsr25 1285 6 und und NNP cord-024189-t7mbsr25 1285 7 rapid rapid NNP cord-024189-t7mbsr25 1285 8 fortschreitender fortschreitender NNP cord-024189-t7mbsr25 1285 9 allgemeiner allgemeiner NNP cord-024189-t7mbsr25 1286 1 muskellahmung muskellahmung NNP cord-024189-t7mbsr25 1286 2 einhergeht einhergeht NNP cord-024189-t7mbsr25 1287 1 Polyarteritis Polyarteritis NNP cord-024189-t7mbsr25 1287 2 nodosa nodosa RB cord-024189-t7mbsr25 1287 3 : : : cord-024189-t7mbsr25 1287 4 commemorative commemorative JJ cord-024189-t7mbsr25 1287 5 translation translation NN cord-024189-t7mbsr25 1287 6 of of IN cord-024189-t7mbsr25 1287 7 the the DT cord-024189-t7mbsr25 1287 8 130-year 130-year CD cord-024189-t7mbsr25 1287 9 anniversary anniversary NN cord-024189-t7mbsr25 1287 10 of of IN cord-024189-t7mbsr25 1287 11 the the DT cord-024189-t7mbsr25 1287 12 original original JJ cord-024189-t7mbsr25 1287 13 article article NN cord-024189-t7mbsr25 1287 14 by by IN cord-024189-t7mbsr25 1287 15 Adolf Adolf NNP cord-024189-t7mbsr25 1287 16 Kussmaul Kussmaul NNP cord-024189-t7mbsr25 1287 17 and and CC cord-024189-t7mbsr25 1287 18 Rudolf Rudolf NNP cord-024189-t7mbsr25 1287 19 Maier Maier NNP cord-024189-t7mbsr25 1287 20 Autoantibodies Autoantibodies NNP cord-024189-t7mbsr25 1287 21 against against IN cord-024189-t7mbsr25 1287 22 neutrophils neutrophil NNS cord-024189-t7mbsr25 1287 23 and and CC cord-024189-t7mbsr25 1287 24 monocytes monocyte NNS cord-024189-t7mbsr25 1287 25 : : : cord-024189-t7mbsr25 1287 26 tool tool NN cord-024189-t7mbsr25 1287 27 for for IN cord-024189-t7mbsr25 1287 28 diagnosis diagnosis NN cord-024189-t7mbsr25 1287 29 and and CC cord-024189-t7mbsr25 1287 30 marker marker NN cord-024189-t7mbsr25 1287 31 of of IN cord-024189-t7mbsr25 1287 32 disease disease NN cord-024189-t7mbsr25 1287 33 activity activity NN cord-024189-t7mbsr25 1287 34 in in IN cord-024189-t7mbsr25 1287 35 Wegener Wegener NNP cord-024189-t7mbsr25 1287 36 's 's POS cord-024189-t7mbsr25 1287 37 granulomatosis granulomatosis NN cord-024189-t7mbsr25 1287 38 Anti anti JJ cord-024189-t7mbsr25 1287 39 - - JJ cord-024189-t7mbsr25 1287 40 neutrophil neutrophil JJ cord-024189-t7mbsr25 1287 41 cytoplasmic cytoplasmic JJ cord-024189-t7mbsr25 1287 42 autoantibodies autoantibody NNS cord-024189-t7mbsr25 1287 43 with with IN cord-024189-t7mbsr25 1287 44 specifi specifi NNP cord-024189-t7mbsr25 1287 45 city city NN cord-024189-t7mbsr25 1287 46 for for IN cord-024189-t7mbsr25 1287 47 myeloperoxidase myeloperoxidase NNP cord-024189-t7mbsr25 1287 48 in in IN cord-024189-t7mbsr25 1287 49 patients patient NNS cord-024189-t7mbsr25 1287 50 with with IN cord-024189-t7mbsr25 1287 51 systemic systemic JJ cord-024189-t7mbsr25 1287 52 vasculitis vasculitis NN cord-024189-t7mbsr25 1287 53 and and CC cord-024189-t7mbsr25 1287 54 idiopathic idiopathic JJ cord-024189-t7mbsr25 1287 55 necrotizing necrotize VBG cord-024189-t7mbsr25 1287 56 and and CC cord-024189-t7mbsr25 1287 57 crescentic crescentic JJ cord-024189-t7mbsr25 1287 58 glomerulonephritis glomerulonephritis NN cord-024189-t7mbsr25 1288 1 The the DT cord-024189-t7mbsr25 1288 2 American American NNP cord-024189-t7mbsr25 1288 3 College College NNP cord-024189-t7mbsr25 1288 4 of of IN cord-024189-t7mbsr25 1288 5 Rheumatology Rheumatology NNP cord-024189-t7mbsr25 1288 6 1990 1990 CD cord-024189-t7mbsr25 1288 7 criteria criterion NNS cord-024189-t7mbsr25 1288 8 for for IN cord-024189-t7mbsr25 1288 9 the the DT cord-024189-t7mbsr25 1288 10 classifi classifi NNP cord-024189-t7mbsr25 1288 11 cation cation NN cord-024189-t7mbsr25 1288 12 of of IN cord-024189-t7mbsr25 1288 13 Wegener Wegener NNP cord-024189-t7mbsr25 1288 14 's 's POS cord-024189-t7mbsr25 1288 15 granulomatosis granulomatosis NN cord-024189-t7mbsr25 1289 1 The the DT cord-024189-t7mbsr25 1289 2 American American NNP cord-024189-t7mbsr25 1289 3 College College NNP cord-024189-t7mbsr25 1289 4 of of IN cord-024189-t7mbsr25 1289 5 Rheumatology Rheumatology NNP cord-024189-t7mbsr25 1289 6 1990 1990 CD cord-024189-t7mbsr25 1289 7 criteria criterion NNS cord-024189-t7mbsr25 1289 8 for for IN cord-024189-t7mbsr25 1289 9 the the DT cord-024189-t7mbsr25 1289 10 classifi classifi NNP cord-024189-t7mbsr25 1289 11 cation cation NN cord-024189-t7mbsr25 1289 12 of of IN cord-024189-t7mbsr25 1289 13 Churg Churg NNP cord-024189-t7mbsr25 1289 14 - - HYPH cord-024189-t7mbsr25 1289 15 Strauss Strauss NNP cord-024189-t7mbsr25 1289 16 syndrome syndrome NN cord-024189-t7mbsr25 1289 17 ( ( -LRB- cord-024189-t7mbsr25 1289 18 allergic allergic JJ cord-024189-t7mbsr25 1289 19 granulomatosis granulomatosis NN cord-024189-t7mbsr25 1289 20 and and CC cord-024189-t7mbsr25 1289 21 angiitis angiitis NNP cord-024189-t7mbsr25 1289 22 ) ) -RRB- cord-024189-t7mbsr25 1290 1 The the DT cord-024189-t7mbsr25 1290 2 American American NNP cord-024189-t7mbsr25 1290 3 College College NNP cord-024189-t7mbsr25 1290 4 of of IN cord-024189-t7mbsr25 1290 5 Rheumatology Rheumatology NNP cord-024189-t7mbsr25 1290 6 1990 1990 CD cord-024189-t7mbsr25 1290 7 criteria criterion NNS cord-024189-t7mbsr25 1290 8 for for IN cord-024189-t7mbsr25 1290 9 the the DT cord-024189-t7mbsr25 1290 10 classifi classifi NNP cord-024189-t7mbsr25 1290 11 cation cation NN cord-024189-t7mbsr25 1290 12 of of IN cord-024189-t7mbsr25 1290 13 giant giant JJ cord-024189-t7mbsr25 1290 14 cell cell NN cord-024189-t7mbsr25 1290 15 arteritis arteritis NN cord-024189-t7mbsr25 1290 16 Nomenclature nomenclature NN cord-024189-t7mbsr25 1290 17 of of IN cord-024189-t7mbsr25 1290 18 systemic systemic JJ cord-024189-t7mbsr25 1290 19 vasculitides vasculitide NNS cord-024189-t7mbsr25 1290 20 . . . cord-024189-t7mbsr25 1291 1 Proposal proposal NN cord-024189-t7mbsr25 1291 2 of of IN cord-024189-t7mbsr25 1291 3 an an DT cord-024189-t7mbsr25 1291 4 international international JJ cord-024189-t7mbsr25 1291 5 consensus consensus NN cord-024189-t7mbsr25 1291 6 conference conference NN cord-024189-t7mbsr25 1291 7 Epidemiology epidemiology NN cord-024189-t7mbsr25 1291 8 of of IN cord-024189-t7mbsr25 1291 9 systemic systemic JJ cord-024189-t7mbsr25 1291 10 vasculitis vasculitis NN cord-024189-t7mbsr25 1291 11 : : : cord-024189-t7mbsr25 1291 12 changing change VBG cord-024189-t7mbsr25 1291 13 incidence incidence NN cord-024189-t7mbsr25 1291 14 or or CC cord-024189-t7mbsr25 1291 15 defi defi NNP cord-024189-t7mbsr25 1291 16 nition nition NN cord-024189-t7mbsr25 1291 17 ? ? . cord-024189-t7mbsr25 1292 1 Wegener Wegener NNP cord-024189-t7mbsr25 1292 2 's 's POS cord-024189-t7mbsr25 1292 3 granulomatosis granulomatosis NN cord-024189-t7mbsr25 1292 4 : : : cord-024189-t7mbsr25 1292 5 an an DT cord-024189-t7mbsr25 1292 6 analysis analysis NN cord-024189-t7mbsr25 1292 7 of of IN cord-024189-t7mbsr25 1292 8 158 158 CD cord-024189-t7mbsr25 1292 9 patients patient NNS cord-024189-t7mbsr25 1292 10 Limited limited JJ cord-024189-t7mbsr25 1292 11 versus versus IN cord-024189-t7mbsr25 1292 12 severe severe JJ cord-024189-t7mbsr25 1292 13 Wegener Wegener NNP cord-024189-t7mbsr25 1292 14 's 's POS cord-024189-t7mbsr25 1292 15 granulomatosis granulomatosis NN cord-024189-t7mbsr25 1292 16 : : : cord-024189-t7mbsr25 1292 17 baseline baseline JJ cord-024189-t7mbsr25 1292 18 data datum NNS cord-024189-t7mbsr25 1292 19 on on IN cord-024189-t7mbsr25 1292 20 patients patient NNS cord-024189-t7mbsr25 1292 21 in in IN cord-024189-t7mbsr25 1292 22 the the DT cord-024189-t7mbsr25 1292 23 Wegener Wegener NNP cord-024189-t7mbsr25 1292 24 's 's POS cord-024189-t7mbsr25 1292 25 granulomatosis granulomatosis NN cord-024189-t7mbsr25 1292 26 etanercept etanercept NNP cord-024189-t7mbsr25 1292 27 trial trial NN cord-024189-t7mbsr25 1292 28 Antineutrophil Antineutrophil NNP cord-024189-t7mbsr25 1292 29 cytoplasmic cytoplasmic JJ cord-024189-t7mbsr25 1292 30 antibodies antibody NNS cord-024189-t7mbsr25 1292 31 Test test VBP cord-024189-t7mbsr25 1292 32 characteristics characteristic NNS cord-024189-t7mbsr25 1292 33 of of IN cord-024189-t7mbsr25 1292 34 immunofl immunofl NN cord-024189-t7mbsr25 1292 35 uorescence uorescence NNP cord-024189-t7mbsr25 1292 36 and and CC cord-024189-t7mbsr25 1292 37 ELISA ELISA NNP cord-024189-t7mbsr25 1292 38 tests test VBZ cord-024189-t7mbsr25 1292 39 in in IN cord-024189-t7mbsr25 1292 40 856 856 CD cord-024189-t7mbsr25 1292 41 consecutive consecutive JJ cord-024189-t7mbsr25 1292 42 patients patient NNS cord-024189-t7mbsr25 1292 43 with with IN cord-024189-t7mbsr25 1292 44 possible possible JJ cord-024189-t7mbsr25 1292 45 ANCA ANCA NNP cord-024189-t7mbsr25 1292 46 - - HYPH cord-024189-t7mbsr25 1292 47 associated associate VBN cord-024189-t7mbsr25 1292 48 conditions condition NNS cord-024189-t7mbsr25 1292 49 Prediction Prediction NNP cord-024189-t7mbsr25 1292 50 of of IN cord-024189-t7mbsr25 1292 51 relapses relapse NNS cord-024189-t7mbsr25 1292 52 in in IN cord-024189-t7mbsr25 1292 53 Wegener Wegener NNP cord-024189-t7mbsr25 1292 54 's 's POS cord-024189-t7mbsr25 1292 55 granulomatosis granulomatosis NN cord-024189-t7mbsr25 1292 56 by by IN cord-024189-t7mbsr25 1292 57 measurement measurement NN cord-024189-t7mbsr25 1292 58 of of IN cord-024189-t7mbsr25 1292 59 antineutrophil antineutrophil NNP cord-024189-t7mbsr25 1292 60 cytoplasmic cytoplasmic JJ cord-024189-t7mbsr25 1292 61 antibody antibody NN cord-024189-t7mbsr25 1292 62 levels level NNS cord-024189-t7mbsr25 1292 63 : : : cord-024189-t7mbsr25 1292 64 a a DT cord-024189-t7mbsr25 1292 65 prospective prospective JJ cord-024189-t7mbsr25 1292 66 study study NN cord-024189-t7mbsr25 1292 67 Antineutrophil Antineutrophil NNP cord-024189-t7mbsr25 1292 68 cytoplasmic cytoplasmic JJ cord-024189-t7mbsr25 1292 69 antibodies antibody NNS cord-024189-t7mbsr25 1292 70 against against IN cord-024189-t7mbsr25 1292 71 proteinase proteinase NN cord-024189-t7mbsr25 1292 72 3 3 CD cord-024189-t7mbsr25 1292 73 do do VBP cord-024189-t7mbsr25 1292 74 not not RB cord-024189-t7mbsr25 1292 75 predict predict VB cord-024189-t7mbsr25 1292 76 disease disease NN cord-024189-t7mbsr25 1292 77 relapses relapse NNS cord-024189-t7mbsr25 1292 78 in in IN cord-024189-t7mbsr25 1292 79 Wegener Wegener NNP cord-024189-t7mbsr25 1292 80 's 's POS cord-024189-t7mbsr25 1292 81 granulomatosis granulomatosis NN cord-024189-t7mbsr25 1292 82 Antineutrophil Antineutrophil NNP cord-024189-t7mbsr25 1292 83 cytoplasmic cytoplasmic JJ cord-024189-t7mbsr25 1292 84 autoantibodies autoantibody NNS cord-024189-t7mbsr25 1292 85 specifi specifi NNP cord-024189-t7mbsr25 1292 86 c c NN cord-024189-t7mbsr25 1292 87 for for IN cord-024189-t7mbsr25 1292 88 myeloperoxidase myeloperoxidase NNP cord-024189-t7mbsr25 1292 89 cause cause VBP cord-024189-t7mbsr25 1292 90 glomerulonephritis glomerulonephritis NN cord-024189-t7mbsr25 1292 91 and and CC cord-024189-t7mbsr25 1292 92 vasculitis vasculitis NN cord-024189-t7mbsr25 1292 93 in in IN cord-024189-t7mbsr25 1292 94 mice mouse NNS cord-024189-t7mbsr25 1292 95 Drug Drug NNP cord-024189-t7mbsr25 1292 96 - - HYPH cord-024189-t7mbsr25 1292 97 associated associate VBN cord-024189-t7mbsr25 1292 98 antineutrophil antineutrophil NNP cord-024189-t7mbsr25 1292 99 cytoplasmic cytoplasmic JJ cord-024189-t7mbsr25 1292 100 antibody antibody NN cord-024189-t7mbsr25 1292 101 - - HYPH cord-024189-t7mbsr25 1292 102 positive positive JJ cord-024189-t7mbsr25 1292 103 vasculitis vasculitis NN cord-024189-t7mbsr25 1292 104 : : : cord-024189-t7mbsr25 1292 105 prevalence prevalence NN cord-024189-t7mbsr25 1292 106 among among IN cord-024189-t7mbsr25 1292 107 patients patient NNS cord-024189-t7mbsr25 1292 108 with with IN cord-024189-t7mbsr25 1292 109 high high JJ cord-024189-t7mbsr25 1292 110 titers titer NNS cord-024189-t7mbsr25 1292 111 of of IN cord-024189-t7mbsr25 1292 112 antimyeloperoxidase antimyeloperoxidase NN cord-024189-t7mbsr25 1292 113 antibodies antibody NNS cord-024189-t7mbsr25 1292 114 Rituximab Rituximab NNP cord-024189-t7mbsr25 1292 115 for for IN cord-024189-t7mbsr25 1292 116 refractory refractory JJ cord-024189-t7mbsr25 1292 117 Wegener Wegener NNP cord-024189-t7mbsr25 1292 118 's 's POS cord-024189-t7mbsr25 1292 119 granulomatosis granulomatosis NN cord-024189-t7mbsr25 1292 120 : : : cord-024189-t7mbsr25 1292 121 report report NN cord-024189-t7mbsr25 1292 122 of of IN cord-024189-t7mbsr25 1292 123 a a DT cord-024189-t7mbsr25 1292 124 prospective prospective JJ cord-024189-t7mbsr25 1292 125 , , , cord-024189-t7mbsr25 1292 126 open open JJ cord-024189-t7mbsr25 1292 127 - - HYPH cord-024189-t7mbsr25 1292 128 label label NN cord-024189-t7mbsr25 1292 129 pilot pilot NN cord-024189-t7mbsr25 1292 130 trial trial NN cord-024189-t7mbsr25 1292 131 Therapeutics Therapeutics NNP cord-024189-t7mbsr25 1292 132 for for IN cord-024189-t7mbsr25 1292 133 Wegener Wegener NNP cord-024189-t7mbsr25 1292 134 's 's POS cord-024189-t7mbsr25 1292 135 granulomatosis granulomatosis NN cord-024189-t7mbsr25 1292 136 Design Design NNP cord-024189-t7mbsr25 1292 137 of of IN cord-024189-t7mbsr25 1292 138 the the DT cord-024189-t7mbsr25 1292 139 Wegener Wegener NNP cord-024189-t7mbsr25 1292 140 's 's POS cord-024189-t7mbsr25 1292 141 Granulomatosis Granulomatosis NNP cord-024189-t7mbsr25 1292 142 Etanercept Etanercept NNP cord-024189-t7mbsr25 1292 143 Trial Trial NNP cord-024189-t7mbsr25 1292 144 ( ( -LRB- cord-024189-t7mbsr25 1292 145 WGET WGET NNP cord-024189-t7mbsr25 1292 146 ) ) -RRB- cord-024189-t7mbsr25 1293 1 A a DT cord-024189-t7mbsr25 1293 2 randomized randomized JJ cord-024189-t7mbsr25 1293 3 trial trial NN cord-024189-t7mbsr25 1293 4 of of IN cord-024189-t7mbsr25 1293 5 maintenance maintenance NN cord-024189-t7mbsr25 1293 6 therapy therapy NN cord-024189-t7mbsr25 1293 7 for for IN cord-024189-t7mbsr25 1293 8 vasculitis vasculitis NN cord-024189-t7mbsr25 1293 9 associated associate VBN cord-024189-t7mbsr25 1293 10 with with IN cord-024189-t7mbsr25 1293 11 antineutrophil antineutrophil JJ cord-024189-t7mbsr25 1293 12 cytoplasmic cytoplasmic JJ cord-024189-t7mbsr25 1293 13 autoantibodies autoantibody NNS cord-024189-t7mbsr25 1293 14 A a DT cord-024189-t7mbsr25 1293 15 staged stage VBD cord-024189-t7mbsr25 1293 16 approach approach NN cord-024189-t7mbsr25 1293 17 to to IN cord-024189-t7mbsr25 1293 18 the the DT cord-024189-t7mbsr25 1293 19 treatment treatment NN cord-024189-t7mbsr25 1293 20 of of IN cord-024189-t7mbsr25 1293 21 Wegener Wegener NNP cord-024189-t7mbsr25 1293 22 's 's POS cord-024189-t7mbsr25 1293 23 granulomatosis granulomatosis NN cord-024189-t7mbsr25 1293 24 : : : cord-024189-t7mbsr25 1293 25 induction induction NN cord-024189-t7mbsr25 1293 26 of of IN cord-024189-t7mbsr25 1293 27 remission remission NN cord-024189-t7mbsr25 1293 28 with with IN cord-024189-t7mbsr25 1293 29 glucocorticoids glucocorticoid NNS cord-024189-t7mbsr25 1293 30 and and CC cord-024189-t7mbsr25 1293 31 daily daily JJ cord-024189-t7mbsr25 1293 32 cyclophosphamide cyclophosphamide RB cord-024189-t7mbsr25 1293 33 switching switch VBG cord-024189-t7mbsr25 1293 34 to to IN cord-024189-t7mbsr25 1293 35 methotrexate methotrexate NNP cord-024189-t7mbsr25 1293 36 for for IN cord-024189-t7mbsr25 1293 37 remission remission NN cord-024189-t7mbsr25 1293 38 maintenance maintenance NN cord-024189-t7mbsr25 1293 39 Etanercept Etanercept NNP cord-024189-t7mbsr25 1293 40 in in IN cord-024189-t7mbsr25 1293 41 addition addition NN cord-024189-t7mbsr25 1293 42 to to IN cord-024189-t7mbsr25 1293 43 standard standard JJ cord-024189-t7mbsr25 1293 44 therapy therapy NN cord-024189-t7mbsr25 1293 45 in in IN cord-024189-t7mbsr25 1293 46 patients patient NNS cord-024189-t7mbsr25 1293 47 with with IN cord-024189-t7mbsr25 1293 48 Wegener Wegener NNP cord-024189-t7mbsr25 1293 49 's 's POS cord-024189-t7mbsr25 1293 50 granulomatosis granulomatosis NN cord-024189-t7mbsr25 1293 51 Solid solid JJ cord-024189-t7mbsr25 1293 52 malignancies malignancy NNS cord-024189-t7mbsr25 1293 53 in in IN cord-024189-t7mbsr25 1293 54 the the DT cord-024189-t7mbsr25 1293 55 Wegener Wegener NNP cord-024189-t7mbsr25 1293 56 's 's POS cord-024189-t7mbsr25 1293 57 granulomatosis granulomatosis NN cord-024189-t7mbsr25 1293 58 Etanercept Etanercept NNP cord-024189-t7mbsr25 1293 59 trial trial NN cord-024189-t7mbsr25 1293 60 . . . cord-024189-t7mbsr25 1294 1 Arthritis Arthritis NNP cord-024189-t7mbsr25 1294 2 Treatment Treatment NNP cord-024189-t7mbsr25 1294 3 of of IN cord-024189-t7mbsr25 1294 4 subglottic subglottic JJ cord-024189-t7mbsr25 1294 5 stenosis stenosis NN cord-024189-t7mbsr25 1294 6 , , , cord-024189-t7mbsr25 1294 7 due due IN cord-024189-t7mbsr25 1294 8 to to IN cord-024189-t7mbsr25 1294 9 Wegener Wegener NNP cord-024189-t7mbsr25 1294 10 's 's POS cord-024189-t7mbsr25 1294 11 granulomatosis granulomatosis NN cord-024189-t7mbsr25 1294 12 , , , cord-024189-t7mbsr25 1294 13 with with IN cord-024189-t7mbsr25 1294 14 intralesional intralesional JJ cord-024189-t7mbsr25 1294 15 corticosteroids corticosteroid NNS cord-024189-t7mbsr25 1294 16 and and CC cord-024189-t7mbsr25 1294 17 dilation dilation NN cord-024189-t7mbsr25 1295 1 Outcome outcome NN cord-024189-t7mbsr25 1295 2 of of IN cord-024189-t7mbsr25 1295 3 ANCA ANCA NNP cord-024189-t7mbsr25 1295 4 - - HYPH cord-024189-t7mbsr25 1295 5 associated associate VBN cord-024189-t7mbsr25 1295 6 renal renal JJ cord-024189-t7mbsr25 1295 7 vasculitis vasculitis NN cord-024189-t7mbsr25 1295 8 : : : cord-024189-t7mbsr25 1295 9 a a DT cord-024189-t7mbsr25 1295 10 5-year 5-year CD cord-024189-t7mbsr25 1295 11 retrospective retrospective JJ cord-024189-t7mbsr25 1295 12 study study NN cord-024189-t7mbsr25 1295 13 Damage damage NN cord-024189-t7mbsr25 1295 14 from from IN cord-024189-t7mbsr25 1295 15 Wegener Wegener NNP cord-024189-t7mbsr25 1295 16 's 's POS cord-024189-t7mbsr25 1295 17 granulomatosis granulomatosis NN cord-024189-t7mbsr25 1295 18 and and CC cord-024189-t7mbsr25 1295 19 its -PRON- PRP$ cord-024189-t7mbsr25 1295 20 treatment treatment NN cord-024189-t7mbsr25 1295 21 : : : cord-024189-t7mbsr25 1295 22 prospective prospective JJ cord-024189-t7mbsr25 1295 23 data datum NNS cord-024189-t7mbsr25 1295 24 from from IN cord-024189-t7mbsr25 1295 25 the the DT cord-024189-t7mbsr25 1295 26 Wegener Wegener NNP cord-024189-t7mbsr25 1295 27 's 's POS cord-024189-t7mbsr25 1295 28 Granulomatosis Granulomatosis NNP cord-024189-t7mbsr25 1295 29 Etanercept Etanercept NNP cord-024189-t7mbsr25 1295 30 Trial Trial NNP cord-024189-t7mbsr25 1295 31 Injections Injections NNP cord-024189-t7mbsr25 1295 32 repetees repetee NNS cord-024189-t7mbsr25 1295 33 de de IN cord-024189-t7mbsr25 1295 34 serum serum NNP cord-024189-t7mbsr25 1295 35 de de FW cord-024189-t7mbsr25 1295 36 cheval cheval NNP cord-024189-t7mbsr25 1295 37 cuez cuez NNP cord-024189-t7mbsr25 1295 38 le le NNP cord-024189-t7mbsr25 1295 39 lapin lapin NNP cord-024189-t7mbsr25 1295 40 . . . cord-024189-t7mbsr25 1296 1 Seances Seances NNP cord-024189-t7mbsr25 1296 2 et et NNP cord-024189-t7mbsr25 1296 3 Memoire Memoire NNP cord-024189-t7mbsr25 1296 4 de de NNP cord-024189-t7mbsr25 1296 5 la la NNP cord-024189-t7mbsr25 1296 6 Societe Societe NNP cord-024189-t7mbsr25 1296 7 de de FW cord-024189-t7mbsr25 1296 8 Direct direct JJ cord-024189-t7mbsr25 1296 9 immunofl immunofl NN cord-024189-t7mbsr25 1296 10 uorescence uorescence NN cord-024189-t7mbsr25 1296 11 of of IN cord-024189-t7mbsr25 1296 12 a a DT cord-024189-t7mbsr25 1296 13 skin skin NN cord-024189-t7mbsr25 1296 14 biopsy biopsy NN cord-024189-t7mbsr25 1296 15 in in IN cord-024189-t7mbsr25 1296 16 urticarial urticarial JJ cord-024189-t7mbsr25 1296 17 vasculitis vasculitis NN cord-024189-t7mbsr25 1296 18 . . . cord-024189-t7mbsr25 1297 1 The the DT cord-024189-t7mbsr25 1297 2 immunostaining immunostaining NN cord-024189-t7mbsr25 1297 3 shows show VBZ cord-024189-t7mbsr25 1297 4 immunoreactant immunoreactant JJ cord-024189-t7mbsr25 1297 5 deposition deposition NN cord-024189-t7mbsr25 1297 6 within within IN cord-024189-t7mbsr25 1297 7 small small JJ cord-024189-t7mbsr25 1297 8 blood blood NN cord-024189-t7mbsr25 1297 9 vessels vessel NNS cord-024189-t7mbsr25 1297 10 in in IN cord-024189-t7mbsr25 1297 11 the the DT cord-024189-t7mbsr25 1297 12 superfi superfi NNS cord-024189-t7mbsr25 1297 13 cial cial JJ cord-024189-t7mbsr25 1297 14 dermis dermis NN cord-024189-t7mbsr25 1297 15 , , , cord-024189-t7mbsr25 1297 16 and and CC cord-024189-t7mbsr25 1297 17 fl fl NNP cord-024189-t7mbsr25 1297 18 orid orid NN cord-024189-t7mbsr25 1297 19 deposition deposition NN cord-024189-t7mbsr25 1297 20 along along IN cord-024189-t7mbsr25 1297 21 the the DT cord-024189-t7mbsr25 1297 22 dermal dermal JJ cord-024189-t7mbsr25 1297 23 - - HYPH cord-024189-t7mbsr25 1297 24 epidermal epidermal JJ cord-024189-t7mbsr25 1297 25 junction junction NN cord-024189-t7mbsr25 1297 26 . . . cord-024189-t7mbsr25 1298 1 ( ( -LRB- cord-024189-t7mbsr25 1298 2 Courtesy courtesy NN cord-024189-t7mbsr25 1298 3 of of IN cord-024189-t7mbsr25 1298 4 Dr Dr NNP cord-024189-t7mbsr25 1298 5 The the DT cord-024189-t7mbsr25 1298 6 American American NNP cord-024189-t7mbsr25 1298 7 College College NNP cord-024189-t7mbsr25 1298 8 of of IN cord-024189-t7mbsr25 1298 9 Rheumatology Rheumatology NNP cord-024189-t7mbsr25 1298 10 1990 1990 CD cord-024189-t7mbsr25 1298 11 criteria criterion NNS cord-024189-t7mbsr25 1298 12 for for IN cord-024189-t7mbsr25 1298 13 the the DT cord-024189-t7mbsr25 1298 14 classifi classifi NNP cord-024189-t7mbsr25 1298 15 cation cation NN cord-024189-t7mbsr25 1298 16 of of IN cord-024189-t7mbsr25 1299 1 hypersensitivity hypersensitivity NN cord-024189-t7mbsr25 1299 2 vasculitis vasculitis NN cord-024189-t7mbsr25 1299 3 Hyperproteinemia Hyperproteinemia NNP cord-024189-t7mbsr25 1299 4 associated associate VBN cord-024189-t7mbsr25 1299 5 with with IN cord-024189-t7mbsr25 1299 6 multiple multiple JJ cord-024189-t7mbsr25 1299 7 myeloma myeloma NN cord-024189-t7mbsr25 1299 8 : : : cord-024189-t7mbsr25 1299 9 with with IN cord-024189-t7mbsr25 1299 10 report report NN cord-024189-t7mbsr25 1299 11 of of IN cord-024189-t7mbsr25 1299 12 a a DT cord-024189-t7mbsr25 1299 13 case case NN cord-024189-t7mbsr25 1299 14 in in IN cord-024189-t7mbsr25 1299 15 which which WDT cord-024189-t7mbsr25 1299 16 an an DT cord-024189-t7mbsr25 1299 17 extraordinary extraordinary JJ cord-024189-t7mbsr25 1299 18 hyperproteinemia hyperproteinemia NN cord-024189-t7mbsr25 1299 19 was be VBD cord-024189-t7mbsr25 1299 20 associated associate VBN cord-024189-t7mbsr25 1299 21 with with IN cord-024189-t7mbsr25 1299 22 thrombosis thrombosis NN cord-024189-t7mbsr25 1299 23 of of IN cord-024189-t7mbsr25 1299 24 the the DT cord-024189-t7mbsr25 1299 25 retinal retinal JJ cord-024189-t7mbsr25 1299 26 veins vein NNS cord-024189-t7mbsr25 1299 27 and and CC cord-024189-t7mbsr25 1299 28 symptoms symptom NNS cord-024189-t7mbsr25 1299 29 suggesting suggest VBG cord-024189-t7mbsr25 1299 30 Raynaud Raynaud NNP cord-024189-t7mbsr25 1299 31 's 's POS cord-024189-t7mbsr25 1299 32 disease disease NN cord-024189-t7mbsr25 1299 33 Cryoglobulinemic Cryoglobulinemic NNP cord-024189-t7mbsr25 1299 34 vasculitis vasculitis NN cord-024189-t7mbsr25 1299 35 The the DT cord-024189-t7mbsr25 1299 36 American American NNP cord-024189-t7mbsr25 1299 37 College College NNP cord-024189-t7mbsr25 1299 38 of of IN cord-024189-t7mbsr25 1299 39 Rheumatology Rheumatology NNP cord-024189-t7mbsr25 1299 40 1990 1990 CD cord-024189-t7mbsr25 1299 41 criteria criterion NNS cord-024189-t7mbsr25 1299 42 for for IN cord-024189-t7mbsr25 1299 43 the the DT cord-024189-t7mbsr25 1299 44 classifi classifi NNP cord-024189-t7mbsr25 1299 45 cation cation NN cord-024189-t7mbsr25 1299 46 of of IN cord-024189-t7mbsr25 1299 47 Henoch Henoch NNP cord-024189-t7mbsr25 1299 48 - - HYPH cord-024189-t7mbsr25 1299 49 Schönlein Schönlein NNP cord-024189-t7mbsr25 1299 50 purpura purpura NN cord-024189-t7mbsr25 1299 51 Henoch Henoch NNP cord-024189-t7mbsr25 1299 52 - - HYPH cord-024189-t7mbsr25 1299 53 Schonlein Schonlein NNP cord-024189-t7mbsr25 1299 54 purpura purpura NN cord-024189-t7mbsr25 1299 55 in in IN cord-024189-t7mbsr25 1299 56 adulthood adulthood NN cord-024189-t7mbsr25 1299 57 and and CC cord-024189-t7mbsr25 1299 58 childhood childhood NN cord-024189-t7mbsr25 1299 59 : : : cord-024189-t7mbsr25 1299 60 two two CD cord-024189-t7mbsr25 1299 61 different different JJ cord-024189-t7mbsr25 1299 62 expressions expression NNS cord-024189-t7mbsr25 1299 63 of of IN cord-024189-t7mbsr25 1299 64 the the DT cord-024189-t7mbsr25 1299 65 same same JJ cord-024189-t7mbsr25 1299 66 syndrome syndrome NN cord-024189-t7mbsr25 1299 67 Treatment Treatment NNP cord-024189-t7mbsr25 1299 68 of of IN cord-024189-t7mbsr25 1299 69 Henoch Henoch NNP cord-024189-t7mbsr25 1299 70 - - HYPH cord-024189-t7mbsr25 1299 71 Schonlein Schonlein NNP cord-024189-t7mbsr25 1299 72 purpura purpura NN cord-024189-t7mbsr25 1299 73 glomerulonephritis glomerulonephritis NN cord-024189-t7mbsr25 1299 74 in in IN cord-024189-t7mbsr25 1299 75 children child NNS cord-024189-t7mbsr25 1299 76 with with IN cord-024189-t7mbsr25 1299 77 high high JJ cord-024189-t7mbsr25 1299 78 - - HYPH cord-024189-t7mbsr25 1299 79 dose dose NN cord-024189-t7mbsr25 1299 80 corticosteroids corticosteroid NNS cord-024189-t7mbsr25 1299 81 plus plus CC cord-024189-t7mbsr25 1299 82 oral oral JJ cord-024189-t7mbsr25 1299 83 cyclophosphamide cyclophosphamide NN cord-024189-t7mbsr25 1299 84 Urticarial urticarial JJ cord-024189-t7mbsr25 1299 85 vasculitis vasculitis NN cord-024189-t7mbsr25 1299 86 and and CC cord-024189-t7mbsr25 1299 87 hypocomplementemic hypocomplementemic JJ cord-024189-t7mbsr25 1299 88 urticarial urticarial JJ cord-024189-t7mbsr25 1299 89 vasculitis vasculitis NNP cord-024189-t7mbsr25 1299 90 syndrome syndrome NN cord-024189-t7mbsr25 1300 1 REFERENCES reference NNS cord-024189-t7mbsr25 1300 2 1 1 CD cord-024189-t7mbsr25 1300 3 . . . cord-024189-t7mbsr25 1301 1 International International NNP cord-024189-t7mbsr25 1301 2 Study Study NNP cord-024189-t7mbsr25 1301 3 Group Group NNP cord-024189-t7mbsr25 1301 4 for for IN cord-024189-t7mbsr25 1301 5 Behçet Behçet NNP cord-024189-t7mbsr25 1301 6 's 's POS cord-024189-t7mbsr25 1301 7 Disease Disease NNP cord-024189-t7mbsr25 1301 8 . . . cord-024189-t7mbsr25 1302 1 Criteria criterion NNS cord-024189-t7mbsr25 1302 2 for for IN cord-024189-t7mbsr25 1302 3 diagnosis diagnosis NN cord-024189-t7mbsr25 1302 4 of of IN cord-024189-t7mbsr25 1302 5 Behçet Behçet NNP cord-024189-t7mbsr25 1302 6 's 's POS cord-024189-t7mbsr25 1302 7 disease disease NN cord-024189-t7mbsr25 1303 1 The the DT cord-024189-t7mbsr25 1303 2 long long JJ cord-024189-t7mbsr25 1303 3 - - HYPH cord-024189-t7mbsr25 1303 4 term term NN cord-024189-t7mbsr25 1303 5 mortality mortality NN cord-024189-t7mbsr25 1303 6 and and CC cord-024189-t7mbsr25 1303 7 morbidity morbidity NN cord-024189-t7mbsr25 1303 8 of of IN cord-024189-t7mbsr25 1303 9 Behcet Behcet NNP cord-024189-t7mbsr25 1303 10 syndrome syndrome NN cord-024189-t7mbsr25 1303 11 : : : cord-024189-t7mbsr25 1303 12 a a DT cord-024189-t7mbsr25 1303 13 2-decade 2-decade CD cord-024189-t7mbsr25 1303 14 outcome outcome NN cord-024189-t7mbsr25 1303 15 survey survey NN cord-024189-t7mbsr25 1303 16 of of IN cord-024189-t7mbsr25 1303 17 387 387 CD cord-024189-t7mbsr25 1303 18 patients patient NNS cord-024189-t7mbsr25 1303 19 followed follow VBD cord-024189-t7mbsr25 1303 20 at at IN cord-024189-t7mbsr25 1303 21 a a DT cord-024189-t7mbsr25 1303 22 dedicated dedicated JJ cord-024189-t7mbsr25 1303 23 center center NN cord-024189-t7mbsr25 1303 24 Major major JJ cord-024189-t7mbsr25 1303 25 vessel vessel NN cord-024189-t7mbsr25 1303 26 involvement involvement NN cord-024189-t7mbsr25 1303 27 in in IN cord-024189-t7mbsr25 1303 28 Behcet Behcet NNP cord-024189-t7mbsr25 1303 29 disease disease NN cord-024189-t7mbsr25 1303 30 Arterial arterial JJ cord-024189-t7mbsr25 1303 31 lesions lesion NNS cord-024189-t7mbsr25 1303 32 in in IN cord-024189-t7mbsr25 1303 33 Behçet Behçet NNP cord-024189-t7mbsr25 1303 34 's 's POS cord-024189-t7mbsr25 1303 35 disease disease NN cord-024189-t7mbsr25 1303 36 . . . cord-024189-t7mbsr25 1304 1 A a DT cord-024189-t7mbsr25 1304 2 study study NN cord-024189-t7mbsr25 1304 3 in in IN cord-024189-t7mbsr25 1304 4 25 25 CD cord-024189-t7mbsr25 1304 5 patients patient NNS cord-024189-t7mbsr25 1304 6 Pulmonary pulmonary JJ cord-024189-t7mbsr25 1304 7 artery artery NN cord-024189-t7mbsr25 1304 8 aneurysms aneurysm NNS cord-024189-t7mbsr25 1304 9 in in IN cord-024189-t7mbsr25 1304 10 Behcet Behcet NNP cord-024189-t7mbsr25 1304 11 syndrome syndrome NN cord-024189-t7mbsr25 1304 12 Neuro Neuro NNP cord-024189-t7mbsr25 1304 13 - - HYPH cord-024189-t7mbsr25 1304 14 Behcet Behcet NNP cord-024189-t7mbsr25 1304 15 disease disease NN cord-024189-t7mbsr25 1304 16 . . . cord-024189-t7mbsr25 1305 1 A a DT cord-024189-t7mbsr25 1305 2 review review NN cord-024189-t7mbsr25 1305 3 Is be VBZ cord-024189-t7mbsr25 1305 4 there there EX cord-024189-t7mbsr25 1305 5 a a DT cord-024189-t7mbsr25 1305 6 place place NN cord-024189-t7mbsr25 1305 7 for for IN cord-024189-t7mbsr25 1305 8 large large JJ cord-024189-t7mbsr25 1305 9 vessel vessel NN cord-024189-t7mbsr25 1305 10 disease disease NN cord-024189-t7mbsr25 1305 11 in in IN cord-024189-t7mbsr25 1305 12 the the DT cord-024189-t7mbsr25 1305 13 diagnostic diagnostic JJ cord-024189-t7mbsr25 1305 14 criteria criterion NNS cord-024189-t7mbsr25 1305 15 for for IN cord-024189-t7mbsr25 1305 16 Behçet Behçet NNP cord-024189-t7mbsr25 1305 17 's 's POS cord-024189-t7mbsr25 1305 18 disease disease NN cord-024189-t7mbsr25 1305 19 ? ? . cord-024189-t7mbsr25 1306 1 Behçet Behçet NNP cord-024189-t7mbsr25 1306 2 's 's POS cord-024189-t7mbsr25 1306 3 Disease Disease NNP cord-024189-t7mbsr25 1307 1 A a DT cord-024189-t7mbsr25 1307 2 double double JJ cord-024189-t7mbsr25 1307 3 - - HYPH cord-024189-t7mbsr25 1307 4 blind blind JJ cord-024189-t7mbsr25 1307 5 trial trial NN cord-024189-t7mbsr25 1307 6 of of IN cord-024189-t7mbsr25 1307 7 colchicine colchicine NN cord-024189-t7mbsr25 1307 8 in in IN cord-024189-t7mbsr25 1307 9 Behçet Behçet NNP cord-024189-t7mbsr25 1307 10 's 's POS cord-024189-t7mbsr25 1307 11 syndrome syndrome NN cord-024189-t7mbsr25 1307 12 Azathioprine Azathioprine NNP cord-024189-t7mbsr25 1307 13 in in IN cord-024189-t7mbsr25 1307 14 Behçet Behçet NNP cord-024189-t7mbsr25 1307 15 's 's POS cord-024189-t7mbsr25 1307 16 syndrome syndrome NN cord-024189-t7mbsr25 1307 17 : : : cord-024189-t7mbsr25 1307 18 Effects effect NNS cord-024189-t7mbsr25 1307 19 on on IN cord-024189-t7mbsr25 1307 20 long long JJ cord-024189-t7mbsr25 1307 21 - - HYPH cord-024189-t7mbsr25 1307 22 term term NN cord-024189-t7mbsr25 1307 23 prognosis prognosis NN cord-024189-t7mbsr25 1307 24 Human human JJ cord-024189-t7mbsr25 1307 25 recombinant recombinant NN cord-024189-t7mbsr25 1308 1 interferon interferon NNP cord-024189-t7mbsr25 1308 2 alfa-2a alfa-2a NNP cord-024189-t7mbsr25 1308 3 for for IN cord-024189-t7mbsr25 1308 4 the the DT cord-024189-t7mbsr25 1308 5 treatment treatment NN cord-024189-t7mbsr25 1308 6 of of IN cord-024189-t7mbsr25 1308 7 Behçet Behçet NNP cord-024189-t7mbsr25 1308 8 's 's POS cord-024189-t7mbsr25 1308 9 disease disease NN cord-024189-t7mbsr25 1308 10 with with IN cord-024189-t7mbsr25 1308 11 sight sight NN cord-024189-t7mbsr25 1308 12 threatening threaten VBG cord-024189-t7mbsr25 1308 13 posterior posterior JJ cord-024189-t7mbsr25 1308 14 or or CC cord-024189-t7mbsr25 1308 15 panuveitis panuveitis JJ cord-024189-t7mbsr25 1308 16 Short short JJ cord-024189-t7mbsr25 1308 17 - - HYPH cord-024189-t7mbsr25 1308 18 term term NN cord-024189-t7mbsr25 1308 19 trial trial NN cord-024189-t7mbsr25 1308 20 of of IN cord-024189-t7mbsr25 1308 21 etanercept etanercept NNP cord-024189-t7mbsr25 1308 22 in in IN cord-024189-t7mbsr25 1308 23 Behcet Behcet NNP cord-024189-t7mbsr25 1308 24 's 's POS cord-024189-t7mbsr25 1308 25 disease disease NN cord-024189-t7mbsr25 1308 26 : : : cord-024189-t7mbsr25 1308 27 a a DT cord-024189-t7mbsr25 1308 28 double double JJ cord-024189-t7mbsr25 1308 29 blind blind JJ cord-024189-t7mbsr25 1308 30 , , , cord-024189-t7mbsr25 1308 31 placebo placebo NN cord-024189-t7mbsr25 1308 32 controlled control VBN cord-024189-t7mbsr25 1308 33 study study NN cord-024189-t7mbsr25 1308 34 Excessive excessive JJ cord-024189-t7mbsr25 1308 35 function function NN cord-024189-t7mbsr25 1308 36 of of IN cord-024189-t7mbsr25 1308 37 peripheral peripheral JJ cord-024189-t7mbsr25 1308 38 blood blood NN cord-024189-t7mbsr25 1308 39 neutrophils neutrophil NNS cord-024189-t7mbsr25 1308 40 from from IN cord-024189-t7mbsr25 1308 41 patients patient NNS cord-024189-t7mbsr25 1308 42 with with IN cord-024189-t7mbsr25 1308 43 Behçet Behçet NNP cord-024189-t7mbsr25 1308 44 's 's POS cord-024189-t7mbsr25 1308 45 disease disease NN cord-024189-t7mbsr25 1308 46 and and CC cord-024189-t7mbsr25 1308 47 from from IN cord-024189-t7mbsr25 1308 48 HLA HLA NNP cord-024189-t7mbsr25 1308 49 - - HYPH cord-024189-t7mbsr25 1308 50 B51 B51 NNP cord-024189-t7mbsr25 1308 51 transgenic transgenic JJ cord-024189-t7mbsr25 1308 52 mice mouse NNS cord-024189-t7mbsr25 1308 53 Role role NN cord-024189-t7mbsr25 1308 54 of of IN cord-024189-t7mbsr25 1308 55 gamma gamma NN cord-024189-t7mbsr25 1308 56 delta delta NN cord-024189-t7mbsr25 1308 57 T T NNP cord-024189-t7mbsr25 1308 58 cells cell NNS cord-024189-t7mbsr25 1308 59 in in IN cord-024189-t7mbsr25 1308 60 pathogenesis pathogenesis NN cord-024189-t7mbsr25 1308 61 and and CC cord-024189-t7mbsr25 1308 62 diagnosis diagnosis NN cord-024189-t7mbsr25 1308 63 of of IN cord-024189-t7mbsr25 1308 64 Behçet Behçet NNP cord-024189-t7mbsr25 1308 65 's 's POS cord-024189-t7mbsr25 1308 66 disease disease NN cord-024189-t7mbsr25 1309 1 The the DT cord-024189-t7mbsr25 1309 2 role role NN cord-024189-t7mbsr25 1309 3 of of IN cord-024189-t7mbsr25 1309 4 heat heat NN cord-024189-t7mbsr25 1309 5 shock shock NN cord-024189-t7mbsr25 1309 6 protein protein NN cord-024189-t7mbsr25 1309 7 , , , cord-024189-t7mbsr25 1309 8 microbial microbial JJ cord-024189-t7mbsr25 1309 9 and and CC cord-024189-t7mbsr25 1309 10 autoimmune autoimmune JJ cord-024189-t7mbsr25 1309 11 agents agent NNS cord-024189-t7mbsr25 1309 12 in in IN cord-024189-t7mbsr25 1309 13 the the DT cord-024189-t7mbsr25 1309 14 aetiology aetiology NN cord-024189-t7mbsr25 1309 15 of of IN cord-024189-t7mbsr25 1309 16 Behçet Behçet NNP cord-024189-t7mbsr25 1309 17 's 's POS cord-024189-t7mbsr25 1309 18 disease disease NN cord-024189-t7mbsr25 1309 19 Behcet Behcet NNP cord-024189-t7mbsr25 1309 20 's 's POS cord-024189-t7mbsr25 1309 21 disease disease NN cord-024189-t7mbsr25 1309 22 as as IN cord-024189-t7mbsr25 1309 23 an an DT cord-024189-t7mbsr25 1309 24 autoinfl autoinfl NNP cord-024189-t7mbsr25 1309 25 ammatory ammatory NNP cord-024189-t7mbsr25 1309 26 disorder disorder NN cord-024189-t7mbsr25 1309 27 Primary Primary NNP cord-024189-t7mbsr25 1309 28 ( ( -LRB- cord-024189-t7mbsr25 1309 29 granulomatous granulomatous JJ cord-024189-t7mbsr25 1309 30 ) ) -RRB- cord-024189-t7mbsr25 1309 31 angiitis angiitis NN cord-024189-t7mbsr25 1309 32 of of IN cord-024189-t7mbsr25 1309 33 the the DT cord-024189-t7mbsr25 1309 34 central central JJ cord-024189-t7mbsr25 1309 35 nervous nervous JJ cord-024189-t7mbsr25 1309 36 system system NN cord-024189-t7mbsr25 1309 37 : : : cord-024189-t7mbsr25 1309 38 a a DT cord-024189-t7mbsr25 1309 39 clinicopathologic clinicopathologic JJ cord-024189-t7mbsr25 1309 40 analysis analysis NN cord-024189-t7mbsr25 1309 41 of of IN cord-024189-t7mbsr25 1309 42 15 15 CD cord-024189-t7mbsr25 1309 43 new new JJ cord-024189-t7mbsr25 1309 44 cases case NNS cord-024189-t7mbsr25 1309 45 and and CC cord-024189-t7mbsr25 1309 46 a a DT cord-024189-t7mbsr25 1309 47 review review NN cord-024189-t7mbsr25 1309 48 of of IN cord-024189-t7mbsr25 1309 49 the the DT cord-024189-t7mbsr25 1309 50 literature literature NN cord-024189-t7mbsr25 1309 51 Report Report NNP cord-024189-t7mbsr25 1309 52 of of IN cord-024189-t7mbsr25 1309 53 8 8 CD cord-024189-t7mbsr25 1309 54 new new JJ cord-024189-t7mbsr25 1309 55 cases case NNS cord-024189-t7mbsr25 1309 56 , , , cord-024189-t7mbsr25 1309 57 review review NN cord-024189-t7mbsr25 1309 58 of of IN cord-024189-t7mbsr25 1309 59 the the DT cord-024189-t7mbsr25 1309 60 literature literature NN cord-024189-t7mbsr25 1309 61 , , , cord-024189-t7mbsr25 1309 62 and and CC cord-024189-t7mbsr25 1309 63 proposal proposal NN cord-024189-t7mbsr25 1309 64 for for IN cord-024189-t7mbsr25 1309 65 diagnostic diagnostic JJ cord-024189-t7mbsr25 1309 66 criteria criterion NNS cord-024189-t7mbsr25 1310 1 Benign benign JJ cord-024189-t7mbsr25 1310 2 angiopathy angiopathy NNP cord-024189-t7mbsr25 1310 3 : : : cord-024189-t7mbsr25 1310 4 a a DT cord-024189-t7mbsr25 1310 5 distinct distinct JJ cord-024189-t7mbsr25 1310 6 subset subset NN cord-024189-t7mbsr25 1310 7 of of IN cord-024189-t7mbsr25 1310 8 angiographically angiographically JJ cord-024189-t7mbsr25 1310 9 defi defi NNP cord-024189-t7mbsr25 1310 10 ned ned NNP cord-024189-t7mbsr25 1310 11 primary primary NNP cord-024189-t7mbsr25 1310 12 angiitis angiitis NNP cord-024189-t7mbsr25 1310 13 of of IN cord-024189-t7mbsr25 1310 14 the the DT cord-024189-t7mbsr25 1310 15 central central JJ cord-024189-t7mbsr25 1310 16 nervous nervous JJ cord-024189-t7mbsr25 1310 17 system system NN cord-024189-t7mbsr25 1311 1 Angiographically Angiographically NNP cord-024189-t7mbsr25 1311 2 defi defi NNP cord-024189-t7mbsr25 1311 3 ned ned NNP cord-024189-t7mbsr25 1311 4 primary primary JJ cord-024189-t7mbsr25 1311 5 angiitis angiitis NN cord-024189-t7mbsr25 1311 6 of of IN cord-024189-t7mbsr25 1311 7 the the DT cord-024189-t7mbsr25 1311 8 CNS CNS NNP cord-024189-t7mbsr25 1311 9 : : : cord-024189-t7mbsr25 1311 10 is be VBZ cord-024189-t7mbsr25 1311 11 it -PRON- PRP cord-024189-t7mbsr25 1311 12 really really RB cord-024189-t7mbsr25 1311 13 benign benign JJ cord-024189-t7mbsr25 1312 1 Primary primary JJ cord-024189-t7mbsr25 1312 2 central central JJ cord-024189-t7mbsr25 1312 3 nervous nervous JJ cord-024189-t7mbsr25 1312 4 system system NN cord-024189-t7mbsr25 1312 5 vasculitis vasculitis NN cord-024189-t7mbsr25 1312 6 ( ( -LRB- cord-024189-t7mbsr25 1312 7 PCNSV PCNSV NNP cord-024189-t7mbsr25 1312 8 ) ) -RRB- cord-024189-t7mbsr25 1312 9 : : : cord-024189-t7mbsr25 1312 10 Clinical clinical JJ cord-024189-t7mbsr25 1312 11 features feature NNS cord-024189-t7mbsr25 1312 12 and and CC cord-024189-t7mbsr25 1312 13 outcome outcome NN cord-024189-t7mbsr25 1312 14 Syndrome syndrome NN cord-024189-t7mbsr25 1312 15 : : : cord-024189-t7mbsr25 1312 16 a a DT cord-024189-t7mbsr25 1312 17 retrospective retrospective JJ cord-024189-t7mbsr25 1312 18 review review NN cord-024189-t7mbsr25 1312 19 of of IN cord-024189-t7mbsr25 1312 20 60 60 CD cord-024189-t7mbsr25 1312 21 patients patient NNS cord-024189-t7mbsr25 1312 22 throughout throughout IN cord-024189-t7mbsr25 1312 23 a a DT cord-024189-t7mbsr25 1312 24 half half JJ cord-024189-t7mbsr25 1312 25 century century NN cord-024189-t7mbsr25 1313 1 Cogan Cogan NNP cord-024189-t7mbsr25 1313 2 's 's POS cord-024189-t7mbsr25 1313 3 Syndrome Syndrome NNP cord-024189-t7mbsr25 1313 4 Erythema Erythema NNP cord-024189-t7mbsr25 1313 5 elevatum elevatum NN cord-024189-t7mbsr25 1313 6 diutinum diutinum NN cord-024189-t7mbsr25 1313 7 : : : cord-024189-t7mbsr25 1313 8 clinical clinical JJ cord-024189-t7mbsr25 1313 9 , , , cord-024189-t7mbsr25 1313 10 histopathologic histopathologic NNP cord-024189-t7mbsr25 1313 11 , , , cord-024189-t7mbsr25 1313 12 and and CC cord-024189-t7mbsr25 1313 13 immunohistochemical immunohistochemical JJ cord-024189-t7mbsr25 1313 14 characteristics characteristic NNS cord-024189-t7mbsr25 1313 15 of of IN cord-024189-t7mbsr25 1313 16 six six CD cord-024189-t7mbsr25 1313 17 patients patient NNS cord-024189-t7mbsr25 1313 18 Erythema erythema JJ cord-024189-t7mbsr25 1313 19 elevatum elevatum JJ cord-024189-t7mbsr25 1313 20 diutinum diutinum NN cord-024189-t7mbsr25 1313 21 Japanese Japanese NNP cord-024189-t7mbsr25 1313 22 Ministry Ministry NNP cord-024189-t7mbsr25 1313 23 of of IN cord-024189-t7mbsr25 1313 24 Health Health NNP cord-024189-t7mbsr25 1313 25 Criteria Criteria NNP cord-024189-t7mbsr25 1313 26 ( ( -LRB- cord-024189-t7mbsr25 1314 1 coronary coronary JJ cord-024189-t7mbsr25 1314 2 artery artery NN cord-024189-t7mbsr25 1314 3 diameter diameter NN cord-024189-t7mbsr25 1315 1 > > XX cord-024189-t7mbsr25 1315 2 3 3 CD cord-024189-t7mbsr25 1315 3 mm mm NN cord-024189-t7mbsr25 1315 4 in in IN cord-024189-t7mbsr25 1315 5 children child NNS cord-024189-t7mbsr25 1315 6 < < XX cord-024189-t7mbsr25 1315 7 5 5 CD cord-024189-t7mbsr25 1315 8 year year NN cord-024189-t7mbsr25 1315 9 or or CC cord-024189-t7mbsr25 1315 10 > > NN cord-024189-t7mbsr25 1315 11 4 4 CD cord-024189-t7mbsr25 1315 12 mm mm NNS cord-024189-t7mbsr25 1315 13 in in IN cord-024189-t7mbsr25 1315 14 children child NNS cord-024189-t7mbsr25 1316 1 ≥5 ≥5 NNP cord-024189-t7mbsr25 1316 2 years year NNS cord-024189-t7mbsr25 1317 1 , , , cord-024189-t7mbsr25 1317 2 lumen lumen NN cord-024189-t7mbsr25 1317 3 diameter diameter NN cord-024189-t7mbsr25 1317 4 ≥1.5× ≥1.5× NNP cord-024189-t7mbsr25 1317 5 an an DT cord-024189-t7mbsr25 1317 6 adjacent adjacent JJ cord-024189-t7mbsr25 1317 7 segment segment NN cord-024189-t7mbsr25 1317 8 ≥3 ≥3 IN cord-024189-t7mbsr25 1317 9 suggestive suggestive JJ cord-024189-t7mbsr25 1317 10 features feature NNS cord-024189-t7mbsr25 1317 11 : : : cord-024189-t7mbsr25 1318 1 ( ( -LRB- cord-024189-t7mbsr25 1318 2 perivascular perivascular NNP cord-024189-t7mbsr25 1318 3 brightness brightness NNP cord-024189-t7mbsr25 1318 4 , , , cord-024189-t7mbsr25 1318 5 lack lack NN cord-024189-t7mbsr25 1318 6 of of IN cord-024189-t7mbsr25 1318 7 tapering tapering NN cord-024189-t7mbsr25 1318 8 , , , cord-024189-t7mbsr25 1318 9 ↓ ↓ NNP cord-024189-t7mbsr25 1318 10 left leave VBD cord-024189-t7mbsr25 1318 11 venticular venticular JJ cord-024189-t7mbsr25 1318 12 function function NN cord-024189-t7mbsr25 1318 13 , , , cord-024189-t7mbsr25 1318 14 mitral mitral JJ cord-024189-t7mbsr25 1318 15 regurgitation regurgitation NN cord-024189-t7mbsr25 1318 16 , , , cord-024189-t7mbsr25 1318 17 pericardial pericardial JJ cord-024189-t7mbsr25 1318 18 effusion effusion NN cord-024189-t7mbsr25 1318 19 , , , cord-024189-t7mbsr25 1318 20 LAD LAD NNP cord-024189-t7mbsr25 1318 21 or or CC cord-024189-t7mbsr25 1318 22 RCA RCA NNP cord-024189-t7mbsr25 1318 23 z z NNP cord-024189-t7mbsr25 1318 24 scores score NNS cord-024189-t7mbsr25 1318 25 = = SYM cord-024189-t7mbsr25 1318 26 2 2 CD cord-024189-t7mbsr25 1318 27 - - SYM cord-024189-t7mbsr25 1318 28 2.5 2.5 CD cord-024189-t7mbsr25 1318 29 ) ) -RRB- cord-024189-t7mbsr25 1319 1 Left leave VBN cord-024189-t7mbsr25 1319 2 anterior anterior JJ cord-024189-t7mbsr25 1319 3 descending descend VBG cord-024189-t7mbsr25 1319 4 coronary coronary JJ cord-024189-t7mbsr25 1319 5 artery artery NN cord-024189-t7mbsr25 1319 6 . . . cord-024189-t7mbsr25 1320 1 b b LS cord-024189-t7mbsr25 1320 2 Right right JJ cord-024189-t7mbsr25 1320 3 coronary coronary JJ cord-024189-t7mbsr25 1320 4 artery artery NN cord-024189-t7mbsr25 1320 5 . . . cord-024189-t7mbsr25 1321 1 REFERENCES reference NNS cord-024189-t7mbsr25 1321 2 1 1 CD cord-024189-t7mbsr25 1321 3 . . . cord-024189-t7mbsr25 1322 1 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1322 2 T. T. NNP cord-024189-t7mbsr25 1322 3 Acute Acute NNP cord-024189-t7mbsr25 1322 4 febrile febrile JJ cord-024189-t7mbsr25 1322 5 mucocutaneous mucocutaneous JJ cord-024189-t7mbsr25 1322 6 syndrome syndrome NN cord-024189-t7mbsr25 1322 7 with with IN cord-024189-t7mbsr25 1322 8 lymphoid lymphoid JJ cord-024189-t7mbsr25 1322 9 involvement involvement NN cord-024189-t7mbsr25 1322 10 with with IN cord-024189-t7mbsr25 1322 11 specifi specifi NNP cord-024189-t7mbsr25 1322 12 c c NNP cord-024189-t7mbsr25 1322 13 desquamation desquamation NNP cord-024189-t7mbsr25 1322 14 of of IN cord-024189-t7mbsr25 1322 15 the the DT cord-024189-t7mbsr25 1322 16 fi fi NNP cord-024189-t7mbsr25 1322 17 ngers nger NNS cord-024189-t7mbsr25 1322 18 and and CC cord-024189-t7mbsr25 1322 19 toes toe NNS cord-024189-t7mbsr25 1322 20 in in IN cord-024189-t7mbsr25 1322 21 children child NNS cord-024189-t7mbsr25 1323 1 A a DT cord-024189-t7mbsr25 1323 2 new new JJ cord-024189-t7mbsr25 1323 3 infantile infantile JJ cord-024189-t7mbsr25 1323 4 acute acute JJ cord-024189-t7mbsr25 1323 5 febrile febrile JJ cord-024189-t7mbsr25 1323 6 mucocutaneous mucocutaneous JJ cord-024189-t7mbsr25 1323 7 lymph lymph NN cord-024189-t7mbsr25 1323 8 node node NN cord-024189-t7mbsr25 1323 9 syndrome syndrome NN cord-024189-t7mbsr25 1323 10 ( ( -LRB- cord-024189-t7mbsr25 1323 11 MLNS MLNS NNP cord-024189-t7mbsr25 1323 12 ) ) -RRB- cord-024189-t7mbsr25 1323 13 prevailing prevail VBG cord-024189-t7mbsr25 1323 14 in in IN cord-024189-t7mbsr25 1323 15 Japan Japan NNP cord-024189-t7mbsr25 1324 1 In in IN cord-024189-t7mbsr25 1324 2 : : : cord-024189-t7mbsr25 1324 3 Emmanouilides Emmanouilides NNP cord-024189-t7mbsr25 1324 4 GC GC NNP cord-024189-t7mbsr25 1324 5 , , , cord-024189-t7mbsr25 1324 6 ed ed NN cord-024189-t7mbsr25 1324 7 . . . cord-024189-t7mbsr25 1325 1 Moss Moss NNP cord-024189-t7mbsr25 1325 2 and and CC cord-024189-t7mbsr25 1325 3 Adams Adams NNP cord-024189-t7mbsr25 1325 4 heart heart NN cord-024189-t7mbsr25 1325 5 disease disease NN cord-024189-t7mbsr25 1325 6 in in IN cord-024189-t7mbsr25 1325 7 infants infant NNS cord-024189-t7mbsr25 1325 8 , , , cord-024189-t7mbsr25 1325 9 children child NNS cord-024189-t7mbsr25 1325 10 , , , cord-024189-t7mbsr25 1325 11 and and CC cord-024189-t7mbsr25 1325 12 adolescents adolescent NNS cord-024189-t7mbsr25 1325 13 : : : cord-024189-t7mbsr25 1325 14 including include VBG cord-024189-t7mbsr25 1325 15 the the DT cord-024189-t7mbsr25 1325 16 fetus fetus NN cord-024189-t7mbsr25 1325 17 and and CC cord-024189-t7mbsr25 1325 18 young young JJ cord-024189-t7mbsr25 1325 19 adult adult NN cord-024189-t7mbsr25 1325 20 Scarlett Scarlett NNP cord-024189-t7mbsr25 1325 21 fever fever NN cord-024189-t7mbsr25 1325 22 , , , cord-024189-t7mbsr25 1325 23 periarteritis periarteritis NNP cord-024189-t7mbsr25 1325 24 nodosa nodosa NNP cord-024189-t7mbsr25 1325 25 , , , cord-024189-t7mbsr25 1325 26 aneurysm aneurysm NN cord-024189-t7mbsr25 1325 27 of of IN cord-024189-t7mbsr25 1325 28 the the DT cord-024189-t7mbsr25 1325 29 coronary coronary JJ cord-024189-t7mbsr25 1325 30 artery artery NN cord-024189-t7mbsr25 1325 31 with with IN cord-024189-t7mbsr25 1325 32 spontaneous spontaneous JJ cord-024189-t7mbsr25 1325 33 rupture rupture NN cord-024189-t7mbsr25 1325 34 , , , cord-024189-t7mbsr25 1325 35 hemopericardium hemopericardium NNP cord-024189-t7mbsr25 1325 36 Fate Fate NNP cord-024189-t7mbsr25 1325 37 of of IN cord-024189-t7mbsr25 1325 38 coronary coronary JJ cord-024189-t7mbsr25 1325 39 aneurysms aneurysm NNS cord-024189-t7mbsr25 1325 40 in in IN cord-024189-t7mbsr25 1325 41 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1325 42 disease disease NN cord-024189-t7mbsr25 1325 43 : : : cord-024189-t7mbsr25 1325 44 serial serial JJ cord-024189-t7mbsr25 1325 45 coronary coronary NN cord-024189-t7mbsr25 1325 46 angiography angiography NN cord-024189-t7mbsr25 1325 47 and and CC cord-024189-t7mbsr25 1325 48 long long JJ cord-024189-t7mbsr25 1325 49 - - HYPH cord-024189-t7mbsr25 1325 50 term term NN cord-024189-t7mbsr25 1325 51 follow follow NN cord-024189-t7mbsr25 1325 52 - - HYPH cord-024189-t7mbsr25 1325 53 up up NN cord-024189-t7mbsr25 1325 54 study study NN cord-024189-t7mbsr25 1325 55 Myocardial myocardial JJ cord-024189-t7mbsr25 1325 56 infarction infarction NN cord-024189-t7mbsr25 1325 57 in in IN cord-024189-t7mbsr25 1325 58 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1325 59 disease disease NN cord-024189-t7mbsr25 1325 60 : : : cord-024189-t7mbsr25 1326 1 clinical clinical JJ cord-024189-t7mbsr25 1326 2 analyses analysis NNS cord-024189-t7mbsr25 1326 3 in in IN cord-024189-t7mbsr25 1326 4 195 195 CD cord-024189-t7mbsr25 1326 5 cases case NNS cord-024189-t7mbsr25 1326 6 Diagnostic diagnostic JJ cord-024189-t7mbsr25 1326 7 guideline guideline NN cord-024189-t7mbsr25 1326 8 of of IN cord-024189-t7mbsr25 1326 9 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1326 10 disease disease NN cord-024189-t7mbsr25 1326 11 Diagnostic diagnostic JJ cord-024189-t7mbsr25 1326 12 guidelines guideline NNS cord-024189-t7mbsr25 1326 13 for for IN cord-024189-t7mbsr25 1326 14 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1326 15 disease disease NN cord-024189-t7mbsr25 1326 16 Diagnosis diagnosis NN cord-024189-t7mbsr25 1326 17 and and CC cord-024189-t7mbsr25 1326 18 therapy therapy NN cord-024189-t7mbsr25 1326 19 of of IN cord-024189-t7mbsr25 1326 20 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1326 21 disease disease NN cord-024189-t7mbsr25 1326 22 in in IN cord-024189-t7mbsr25 1326 23 children child NNS cord-024189-t7mbsr25 1326 24 Incomplete incomplete JJ cord-024189-t7mbsr25 1326 25 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1326 26 disease disease NN cord-024189-t7mbsr25 1326 27 with with IN cord-024189-t7mbsr25 1326 28 coronary coronary JJ cord-024189-t7mbsr25 1326 29 artery artery NN cord-024189-t7mbsr25 1326 30 involvement involvement NN cord-024189-t7mbsr25 1326 31 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1326 32 disease disease NN cord-024189-t7mbsr25 1326 33 in in IN cord-024189-t7mbsr25 1326 34 infants infant NNS cord-024189-t7mbsr25 1326 35 less less JJR cord-024189-t7mbsr25 1326 36 than than IN cord-024189-t7mbsr25 1326 37 one one CD cord-024189-t7mbsr25 1326 38 year year NN cord-024189-t7mbsr25 1326 39 of of IN cord-024189-t7mbsr25 1326 40 age age NN cord-024189-t7mbsr25 1326 41 Diagnosis diagnosis NN cord-024189-t7mbsr25 1326 42 , , , cord-024189-t7mbsr25 1326 43 treatment treatment NN cord-024189-t7mbsr25 1326 44 , , , cord-024189-t7mbsr25 1326 45 and and CC cord-024189-t7mbsr25 1326 46 long long JJ cord-024189-t7mbsr25 1326 47 term term NN cord-024189-t7mbsr25 1326 48 management management NN cord-024189-t7mbsr25 1326 49 of of IN cord-024189-t7mbsr25 1326 50 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1326 51 disease disease NN cord-024189-t7mbsr25 1326 52 . . . cord-024189-t7mbsr25 1327 1 A a DT cord-024189-t7mbsr25 1327 2 statement statement NN cord-024189-t7mbsr25 1327 3 for for IN cord-024189-t7mbsr25 1327 4 health health NN cord-024189-t7mbsr25 1327 5 professionals professional NNS cord-024189-t7mbsr25 1327 6 from from IN cord-024189-t7mbsr25 1327 7 the the DT cord-024189-t7mbsr25 1327 8 committee committee NN cord-024189-t7mbsr25 1327 9 on on IN cord-024189-t7mbsr25 1327 10 rheumatic rheumatic JJ cord-024189-t7mbsr25 1327 11 fever fever NN cord-024189-t7mbsr25 1327 12 , , , cord-024189-t7mbsr25 1327 13 endocarditis endocarditis NN cord-024189-t7mbsr25 1327 14 , , , cord-024189-t7mbsr25 1327 15 and and CC cord-024189-t7mbsr25 1327 16 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1327 17 disease disease NN cord-024189-t7mbsr25 1327 18 . . . cord-024189-t7mbsr25 1328 1 Council council NN cord-024189-t7mbsr25 1328 2 on on IN cord-024189-t7mbsr25 1328 3 cardiovascular cardiovascular JJ cord-024189-t7mbsr25 1328 4 disease disease NN cord-024189-t7mbsr25 1328 5 in in IN cord-024189-t7mbsr25 1328 6 the the DT cord-024189-t7mbsr25 1328 7 young young JJ cord-024189-t7mbsr25 1328 8 Diagnosis diagnosis NN cord-024189-t7mbsr25 1328 9 , , , cord-024189-t7mbsr25 1328 10 treatment treatment NN cord-024189-t7mbsr25 1328 11 , , , cord-024189-t7mbsr25 1328 12 and and CC cord-024189-t7mbsr25 1328 13 long long JJ cord-024189-t7mbsr25 1328 14 term term NN cord-024189-t7mbsr25 1328 15 management management NN cord-024189-t7mbsr25 1328 16 of of IN cord-024189-t7mbsr25 1328 17 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1328 18 disease disease NN cord-024189-t7mbsr25 1328 19 . . . cord-024189-t7mbsr25 1329 1 A a DT cord-024189-t7mbsr25 1329 2 statement statement NN cord-024189-t7mbsr25 1329 3 for for IN cord-024189-t7mbsr25 1329 4 health health NN cord-024189-t7mbsr25 1329 5 professionals professional NNS cord-024189-t7mbsr25 1329 6 from from IN cord-024189-t7mbsr25 1329 7 the the DT cord-024189-t7mbsr25 1329 8 committee committee NN cord-024189-t7mbsr25 1329 9 on on IN cord-024189-t7mbsr25 1329 10 rheumatic rheumatic JJ cord-024189-t7mbsr25 1329 11 fever fever NN cord-024189-t7mbsr25 1329 12 , , , cord-024189-t7mbsr25 1329 13 endocarditis endocarditis NN cord-024189-t7mbsr25 1329 14 , , , cord-024189-t7mbsr25 1329 15 and and CC cord-024189-t7mbsr25 1329 16 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1329 17 disease disease NN cord-024189-t7mbsr25 1329 18 . . . cord-024189-t7mbsr25 1330 1 Council council NN cord-024189-t7mbsr25 1330 2 on on IN cord-024189-t7mbsr25 1330 3 cardiovascular cardiovascular JJ cord-024189-t7mbsr25 1330 4 disease disease NN cord-024189-t7mbsr25 1330 5 in in IN cord-024189-t7mbsr25 1330 6 the the DT cord-024189-t7mbsr25 1330 7 young young JJ cord-024189-t7mbsr25 1330 8 Epidemiology epidemiology NN cord-024189-t7mbsr25 1330 9 of of IN cord-024189-t7mbsr25 1330 10 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1330 11 disease disease NN cord-024189-t7mbsr25 1330 12 in in IN cord-024189-t7mbsr25 1330 13 the the DT cord-024189-t7mbsr25 1330 14 United United NNP cord-024189-t7mbsr25 1330 15 States States NNP cord-024189-t7mbsr25 1330 16 and and CC cord-024189-t7mbsr25 1330 17 worldwide worldwide JJ cord-024189-t7mbsr25 1330 18 Recurrence recurrence NN cord-024189-t7mbsr25 1330 19 of of IN cord-024189-t7mbsr25 1330 20 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1330 21 disease disease NN cord-024189-t7mbsr25 1330 22 in in IN cord-024189-t7mbsr25 1330 23 a a DT cord-024189-t7mbsr25 1330 24 large large JJ cord-024189-t7mbsr25 1330 25 urban urban JJ cord-024189-t7mbsr25 1330 26 cohort cohort NN cord-024189-t7mbsr25 1330 27 in in IN cord-024189-t7mbsr25 1330 28 the the DT cord-024189-t7mbsr25 1330 29 United United NNP cord-024189-t7mbsr25 1330 30 States States NNP cord-024189-t7mbsr25 1331 1 A a DT cord-024189-t7mbsr25 1331 2 10 10 CD cord-024189-t7mbsr25 1331 3 year year NN cord-024189-t7mbsr25 1331 4 ( ( -LRB- cord-024189-t7mbsr25 1331 5 1984 1984 CD cord-024189-t7mbsr25 1331 6 - - SYM cord-024189-t7mbsr25 1331 7 1993 1993 CD cord-024189-t7mbsr25 1331 8 ) ) -RRB- cord-024189-t7mbsr25 1332 1 United United NNP cord-024189-t7mbsr25 1332 2 States States NNP cord-024189-t7mbsr25 1332 3 hospital hospital NN cord-024189-t7mbsr25 1332 4 survey survey NN cord-024189-t7mbsr25 1332 5 of of IN cord-024189-t7mbsr25 1332 6 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1332 7 disease disease NN cord-024189-t7mbsr25 1332 8 Results result NNS cord-024189-t7mbsr25 1332 9 of of IN cord-024189-t7mbsr25 1332 10 12 12 CD cord-024189-t7mbsr25 1332 11 nationwide nationwide JJ cord-024189-t7mbsr25 1332 12 epidemiological epidemiological JJ cord-024189-t7mbsr25 1332 13 incidence incidence NN cord-024189-t7mbsr25 1332 14 surveys survey NNS cord-024189-t7mbsr25 1332 15 of of IN cord-024189-t7mbsr25 1332 16 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1332 17 disease disease NN cord-024189-t7mbsr25 1332 18 in in IN cord-024189-t7mbsr25 1332 19 Japan Japan NNP cord-024189-t7mbsr25 1332 20 Report Report NNP cord-024189-t7mbsr25 1332 21 of of IN cord-024189-t7mbsr25 1332 22 the the DT cord-024189-t7mbsr25 1332 23 National National NNP cord-024189-t7mbsr25 1332 24 Institutes Institutes NNPS cord-024189-t7mbsr25 1332 25 of of IN cord-024189-t7mbsr25 1332 26 Health Health NNP cord-024189-t7mbsr25 1332 27 workshop workshop NN cord-024189-t7mbsr25 1332 28 on on IN cord-024189-t7mbsr25 1332 29 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1332 30 disease disease NN cord-024189-t7mbsr25 1332 31 Prevalence prevalence NN cord-024189-t7mbsr25 1332 32 of of IN cord-024189-t7mbsr25 1332 33 superantigen superantigen NN cord-024189-t7mbsr25 1332 34 - - HYPH cord-024189-t7mbsr25 1332 35 secreting secrete VBG cord-024189-t7mbsr25 1332 36 bacteria bacteria NNS cord-024189-t7mbsr25 1332 37 in in IN cord-024189-t7mbsr25 1332 38 patients patient NNS cord-024189-t7mbsr25 1332 39 with with IN cord-024189-t7mbsr25 1332 40 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1332 41 disease disease NN cord-024189-t7mbsr25 1332 42 Evidence evidence NN cord-024189-t7mbsr25 1332 43 for for IN cord-024189-t7mbsr25 1332 44 superantigen superantigen NN cord-024189-t7mbsr25 1332 45 involvement involvement NN cord-024189-t7mbsr25 1332 46 in in IN cord-024189-t7mbsr25 1332 47 cardiovascular cardiovascular JJ cord-024189-t7mbsr25 1332 48 injury injury NN cord-024189-t7mbsr25 1332 49 due due IN cord-024189-t7mbsr25 1332 50 to to IN cord-024189-t7mbsr25 1332 51 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1332 52 disease disease NN cord-024189-t7mbsr25 1333 1 Toxic toxic JJ cord-024189-t7mbsr25 1333 2 shock shock NN cord-024189-t7mbsr25 1333 3 syndrome syndrome NN cord-024189-t7mbsr25 1333 4 toxin toxin NN cord-024189-t7mbsr25 1333 5 - - HYPH cord-024189-t7mbsr25 1333 6 secreting secrete VBG cord-024189-t7mbsr25 1333 7 Staphylococcus Staphylococcus NNP cord-024189-t7mbsr25 1333 8 aureus aureus NN cord-024189-t7mbsr25 1333 9 in in IN cord-024189-t7mbsr25 1334 1 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1334 2 syndrome syndrome NN cord-024189-t7mbsr25 1334 3 Selective selective JJ cord-024189-t7mbsr25 1334 4 expansion expansion NN cord-024189-t7mbsr25 1334 5 of of IN cord-024189-t7mbsr25 1334 6 T T NNP cord-024189-t7mbsr25 1334 7 cells cell NNS cord-024189-t7mbsr25 1334 8 expressing express VBG cord-024189-t7mbsr25 1334 9 T t NN cord-024189-t7mbsr25 1334 10 - - HYPH cord-024189-t7mbsr25 1334 11 cell cell NN cord-024189-t7mbsr25 1334 12 receptor receptor NN cord-024189-t7mbsr25 1334 13 variable variable NN cord-024189-t7mbsr25 1334 14 regions region NNS cord-024189-t7mbsr25 1334 15 V v NN cord-024189-t7mbsr25 1334 16 beta beta NN cord-024189-t7mbsr25 1334 17 2 2 CD cord-024189-t7mbsr25 1334 18 and and CC cord-024189-t7mbsr25 1334 19 V v NN cord-024189-t7mbsr25 1334 20 beta beta NN cord-024189-t7mbsr25 1334 21 8 8 CD cord-024189-t7mbsr25 1334 22 in in IN cord-024189-t7mbsr25 1334 23 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1334 24 disease disease NN cord-024189-t7mbsr25 1335 1 In in IN cord-024189-t7mbsr25 1335 2 vitro vitro FW cord-024189-t7mbsr25 1335 3 correlates correlate VBZ cord-024189-t7mbsr25 1335 4 of of IN cord-024189-t7mbsr25 1335 5 L. L. NNP cord-024189-t7mbsr25 1335 6 casei casei NNP cord-024189-t7mbsr25 1335 7 animal animal NN cord-024189-t7mbsr25 1335 8 model model NN cord-024189-t7mbsr25 1335 9 of of IN cord-024189-t7mbsr25 1335 10 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1335 11 Disease Disease NNP cord-024189-t7mbsr25 1335 12 Superantigenic Superantigenic NNP cord-024189-t7mbsr25 1335 13 activity activity NN cord-024189-t7mbsr25 1335 14 is be VBZ cord-024189-t7mbsr25 1335 15 responsible responsible JJ cord-024189-t7mbsr25 1335 16 for for IN cord-024189-t7mbsr25 1335 17 induction induction NN cord-024189-t7mbsr25 1335 18 of of IN cord-024189-t7mbsr25 1335 19 coronary coronary JJ cord-024189-t7mbsr25 1335 20 arteritis arteritis NN cord-024189-t7mbsr25 1335 21 in in IN cord-024189-t7mbsr25 1335 22 mice mouse NNS cord-024189-t7mbsr25 1335 23 : : : cord-024189-t7mbsr25 1335 24 and and CC cord-024189-t7mbsr25 1335 25 animal animal NN cord-024189-t7mbsr25 1335 26 model model NN cord-024189-t7mbsr25 1335 27 for for IN cord-024189-t7mbsr25 1335 28 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1335 29 disease disease NN cord-024189-t7mbsr25 1335 30 IgA IgA NNP cord-024189-t7mbsr25 1335 31 plasma plasma NN cord-024189-t7mbsr25 1335 32 cells cell NNS cord-024189-t7mbsr25 1335 33 in in IN cord-024189-t7mbsr25 1335 34 vascular vascular JJ cord-024189-t7mbsr25 1335 35 tissue tissue NN cord-024189-t7mbsr25 1335 36 of of IN cord-024189-t7mbsr25 1335 37 patients patient NNS cord-024189-t7mbsr25 1335 38 with with IN cord-024189-t7mbsr25 1335 39 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1335 40 syndrome syndrome NN cord-024189-t7mbsr25 1335 41 Oligoclonal Oligoclonal NNP cord-024189-t7mbsr25 1335 42 IgA IgA NNP cord-024189-t7mbsr25 1335 43 response response NN cord-024189-t7mbsr25 1335 44 in in IN cord-024189-t7mbsr25 1335 45 the the DT cord-024189-t7mbsr25 1335 46 vascular vascular JJ cord-024189-t7mbsr25 1335 47 wall wall NN cord-024189-t7mbsr25 1335 48 in in IN cord-024189-t7mbsr25 1335 49 acute acute JJ cord-024189-t7mbsr25 1335 50 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1335 51 disease disease NN cord-024189-t7mbsr25 1335 52 Lymphocyte Lymphocyte NNP cord-024189-t7mbsr25 1335 53 abnormalities abnormality NNS cord-024189-t7mbsr25 1335 54 and and CC cord-024189-t7mbsr25 1335 55 complement complement NN cord-024189-t7mbsr25 1335 56 activation activation NN cord-024189-t7mbsr25 1335 57 in in IN cord-024189-t7mbsr25 1335 58 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1335 59 disease disease NN cord-024189-t7mbsr25 1336 1 Intravenous intravenous JJ cord-024189-t7mbsr25 1336 2 IgG igg NN cord-024189-t7mbsr25 1336 3 infusions infusion NNS cord-024189-t7mbsr25 1336 4 are be VBP cord-024189-t7mbsr25 1336 5 associated associate VBN cord-024189-t7mbsr25 1336 6 with with IN cord-024189-t7mbsr25 1336 7 the the DT cord-024189-t7mbsr25 1336 8 in in FW cord-024189-t7mbsr25 1336 9 vitro vitro FW cord-024189-t7mbsr25 1336 10 inhibition inhibition NN cord-024189-t7mbsr25 1336 11 of of IN cord-024189-t7mbsr25 1336 12 classical classical JJ cord-024189-t7mbsr25 1336 13 pathway pathway NN cord-024189-t7mbsr25 1336 14 - - HYPH cord-024189-t7mbsr25 1336 15 mediated mediate VBN cord-024189-t7mbsr25 1336 16 lysis lysis NN cord-024189-t7mbsr25 1336 17 of of IN cord-024189-t7mbsr25 1336 18 sheep sheep NN cord-024189-t7mbsr25 1336 19 red red JJ cord-024189-t7mbsr25 1336 20 blood blood NN cord-024189-t7mbsr25 1336 21 cells cell NNS cord-024189-t7mbsr25 1336 22 and and CC cord-024189-t7mbsr25 1336 23 a a DT cord-024189-t7mbsr25 1336 24 decrease decrease NN cord-024189-t7mbsr25 1336 25 in in IN cord-024189-t7mbsr25 1336 26 C4d C4d NNP cord-024189-t7mbsr25 1336 27 levels level NNS cord-024189-t7mbsr25 1336 28 in in IN cord-024189-t7mbsr25 1336 29 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1336 30 disease disease NN cord-024189-t7mbsr25 1336 31 Prevalence prevalence NN cord-024189-t7mbsr25 1336 32 of of IN cord-024189-t7mbsr25 1336 33 coronary coronary JJ cord-024189-t7mbsr25 1336 34 artery artery NN cord-024189-t7mbsr25 1336 35 abnormalities abnormality NNS cord-024189-t7mbsr25 1336 36 in in IN cord-024189-t7mbsr25 1336 37 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1336 38 disease disease NN cord-024189-t7mbsr25 1336 39 is be VBZ cord-024189-t7mbsr25 1336 40 highly highly RB cord-024189-t7mbsr25 1336 41 dependent dependent JJ cord-024189-t7mbsr25 1336 42 on on IN cord-024189-t7mbsr25 1336 43 gamma gamma NN cord-024189-t7mbsr25 1336 44 globulin globulin NN cord-024189-t7mbsr25 1336 45 dose dose NN cord-024189-t7mbsr25 1336 46 but but CC cord-024189-t7mbsr25 1336 47 independent independent JJ cord-024189-t7mbsr25 1336 48 of of IN cord-024189-t7mbsr25 1336 49 salicylate salicylate NN cord-024189-t7mbsr25 1336 50 dose dose NN cord-024189-t7mbsr25 1336 51 High High NNP cord-024189-t7mbsr25 1336 52 - - HYPH cord-024189-t7mbsr25 1336 53 dose dose NN cord-024189-t7mbsr25 1336 54 intravenous intravenous JJ cord-024189-t7mbsr25 1336 55 gammaglobulin gammaglobulin NN cord-024189-t7mbsr25 1336 56 for for IN cord-024189-t7mbsr25 1336 57 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1336 58 disease disease NN cord-024189-t7mbsr25 1337 1 The the DT cord-024189-t7mbsr25 1337 2 treatment treatment NN cord-024189-t7mbsr25 1337 3 of of IN cord-024189-t7mbsr25 1337 4 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1337 5 syndrome syndrome NN cord-024189-t7mbsr25 1337 6 with with IN cord-024189-t7mbsr25 1337 7 intravenous intravenous JJ cord-024189-t7mbsr25 1337 8 gamma gamma NN cord-024189-t7mbsr25 1337 9 globulin globulin NN cord-024189-t7mbsr25 1338 1 A a DT cord-024189-t7mbsr25 1338 2 single single JJ cord-024189-t7mbsr25 1338 3 intravenous intravenous JJ cord-024189-t7mbsr25 1338 4 infusion infusion NN cord-024189-t7mbsr25 1338 5 of of IN cord-024189-t7mbsr25 1338 6 gamma gamma NN cord-024189-t7mbsr25 1338 7 globulin globulin NN cord-024189-t7mbsr25 1338 8 as as IN cord-024189-t7mbsr25 1338 9 compared compare VBN cord-024189-t7mbsr25 1338 10 with with IN cord-024189-t7mbsr25 1338 11 four four CD cord-024189-t7mbsr25 1338 12 infusions infusion NNS cord-024189-t7mbsr25 1338 13 in in IN cord-024189-t7mbsr25 1338 14 the the DT cord-024189-t7mbsr25 1338 15 treatment treatment NN cord-024189-t7mbsr25 1338 16 of of IN cord-024189-t7mbsr25 1338 17 acute acute JJ cord-024189-t7mbsr25 1338 18 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1338 19 syndrome syndrome NN cord-024189-t7mbsr25 1338 20 Guidelines guideline NNS cord-024189-t7mbsr25 1338 21 for for IN cord-024189-t7mbsr25 1338 22 long long JJ cord-024189-t7mbsr25 1338 23 - - HYPH cord-024189-t7mbsr25 1338 24 term term NN cord-024189-t7mbsr25 1338 25 management management NN cord-024189-t7mbsr25 1338 26 of of IN cord-024189-t7mbsr25 1338 27 patients patient NNS cord-024189-t7mbsr25 1338 28 with with IN cord-024189-t7mbsr25 1338 29 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1338 30 disease disease NN cord-024189-t7mbsr25 1338 31 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1338 32 disease disease NN cord-024189-t7mbsr25 1338 33 : : : cord-024189-t7mbsr25 1338 34 effect effect NN cord-024189-t7mbsr25 1338 35 of of IN cord-024189-t7mbsr25 1338 36 treatment treatment NN cord-024189-t7mbsr25 1338 37 on on IN cord-024189-t7mbsr25 1338 38 coronary coronary JJ cord-024189-t7mbsr25 1338 39 artery artery NN cord-024189-t7mbsr25 1338 40 involvement involvement NN cord-024189-t7mbsr25 1338 41 Treatment treatment NN cord-024189-t7mbsr25 1338 42 of of IN cord-024189-t7mbsr25 1338 43 immune immune JJ cord-024189-t7mbsr25 1338 44 globulin globulin NN cord-024189-t7mbsr25 1338 45 - - HYPH cord-024189-t7mbsr25 1338 46 resistant resistant JJ cord-024189-t7mbsr25 1338 47 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1338 48 disease disease NN cord-024189-t7mbsr25 1338 49 with with IN cord-024189-t7mbsr25 1338 50 pulsed pulse VBN cord-024189-t7mbsr25 1338 51 doses dose NNS cord-024189-t7mbsr25 1338 52 of of IN cord-024189-t7mbsr25 1338 53 corticosteroids corticosteroid NNS cord-024189-t7mbsr25 1338 54 Corticosteroids Corticosteroids NNPS cord-024189-t7mbsr25 1338 55 in in IN cord-024189-t7mbsr25 1338 56 the the DT cord-024189-t7mbsr25 1338 57 treatment treatment NN cord-024189-t7mbsr25 1338 58 of of IN cord-024189-t7mbsr25 1338 59 the the DT cord-024189-t7mbsr25 1338 60 acute acute JJ cord-024189-t7mbsr25 1338 61 phase phase NN cord-024189-t7mbsr25 1338 62 of of IN cord-024189-t7mbsr25 1338 63 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1338 64 disease disease NN cord-024189-t7mbsr25 1339 1 Re re NN cord-024189-t7mbsr25 1339 2 - - NN cord-024189-t7mbsr25 1339 3 treatment treatment NN cord-024189-t7mbsr25 1339 4 of of IN cord-024189-t7mbsr25 1339 5 immunoglobulin immunoglobulin NN cord-024189-t7mbsr25 1339 6 - - HYPH cord-024189-t7mbsr25 1339 7 resistant resistant JJ cord-024189-t7mbsr25 1339 8 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1339 9 disease disease NN cord-024189-t7mbsr25 1339 10 : : : cord-024189-t7mbsr25 1339 11 a a DT cord-024189-t7mbsr25 1339 12 comparative comparative JJ cord-024189-t7mbsr25 1339 13 study study NN cord-024189-t7mbsr25 1339 14 of of IN cord-024189-t7mbsr25 1339 15 additional additional JJ cord-024189-t7mbsr25 1339 16 immune immune JJ cord-024189-t7mbsr25 1339 17 globulin globulin NN cord-024189-t7mbsr25 1339 18 and and CC cord-024189-t7mbsr25 1339 19 steroid steroid NN cord-024189-t7mbsr25 1339 20 pulse pulse NN cord-024189-t7mbsr25 1339 21 therapy therapy NN cord-024189-t7mbsr25 1339 22 Corticosteroids Corticosteroids NNPS cord-024189-t7mbsr25 1339 23 in in IN cord-024189-t7mbsr25 1339 24 the the DT cord-024189-t7mbsr25 1339 25 initial initial JJ cord-024189-t7mbsr25 1339 26 treatment treatment NN cord-024189-t7mbsr25 1339 27 of of IN cord-024189-t7mbsr25 1339 28 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1339 29 disease disease NN cord-024189-t7mbsr25 1339 30 : : : cord-024189-t7mbsr25 1339 31 report report NN cord-024189-t7mbsr25 1339 32 of of IN cord-024189-t7mbsr25 1339 33 a a DT cord-024189-t7mbsr25 1339 34 randomized randomized JJ cord-024189-t7mbsr25 1339 35 trial trial NN cord-024189-t7mbsr25 1339 36 Imaging Imaging NNP cord-024189-t7mbsr25 1339 37 of of IN cord-024189-t7mbsr25 1339 38 coronary coronary JJ cord-024189-t7mbsr25 1339 39 and and CC cord-024189-t7mbsr25 1339 40 peripheral peripheral JJ cord-024189-t7mbsr25 1339 41 arteries artery NNS cord-024189-t7mbsr25 1339 42 with with IN cord-024189-t7mbsr25 1339 43 magnetic magnetic JJ cord-024189-t7mbsr25 1339 44 resonance resonance NN cord-024189-t7mbsr25 1339 45 angiography angiography NN cord-024189-t7mbsr25 1339 46 ( ( -LRB- cord-024189-t7mbsr25 1339 47 MRA MRA NNP cord-024189-t7mbsr25 1339 48 ) ) -RRB- cord-024189-t7mbsr25 1339 49 in in IN cord-024189-t7mbsr25 1339 50 infants infant NNS cord-024189-t7mbsr25 1339 51 with with IN cord-024189-t7mbsr25 1339 52 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1339 53 disease disease NN cord-024189-t7mbsr25 1339 54 : : : cord-024189-t7mbsr25 1339 55 a a DT cord-024189-t7mbsr25 1339 56 new new JJ cord-024189-t7mbsr25 1339 57 utilization utilization NN cord-024189-t7mbsr25 1339 58 to to TO cord-024189-t7mbsr25 1339 59 guide guide VB cord-024189-t7mbsr25 1339 60 therapy therapy NN cord-024189-t7mbsr25 1339 61 Pentoxifylline Pentoxifylline NNP cord-024189-t7mbsr25 1339 62 and and CC cord-024189-t7mbsr25 1339 63 intravenous intravenous JJ cord-024189-t7mbsr25 1339 64 gamma gamma NN cord-024189-t7mbsr25 1339 65 globulin globulin NN cord-024189-t7mbsr25 1339 66 combination combination NN cord-024189-t7mbsr25 1339 67 therapy therapy NN cord-024189-t7mbsr25 1339 68 for for IN cord-024189-t7mbsr25 1339 69 acute acute JJ cord-024189-t7mbsr25 1339 70 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1339 71 disease disease NN cord-024189-t7mbsr25 1339 72 Pharmacokinetics Pharmacokinetics NNP cord-024189-t7mbsr25 1339 73 and and CC cord-024189-t7mbsr25 1339 74 tolerablility tolerablility NN cord-024189-t7mbsr25 1339 75 assessment assessment NN cord-024189-t7mbsr25 1339 76 of of IN cord-024189-t7mbsr25 1339 77 a a DT cord-024189-t7mbsr25 1339 78 pediatric pediatric JJ cord-024189-t7mbsr25 1339 79 oral oral JJ cord-024189-t7mbsr25 1339 80 formulation formulation NN cord-024189-t7mbsr25 1339 81 of of IN cord-024189-t7mbsr25 1339 82 pentoxifylline pentoxifylline NN cord-024189-t7mbsr25 1339 83 in in IN cord-024189-t7mbsr25 1339 84 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1339 85 disease disease NN cord-024189-t7mbsr25 1339 86 Infl Infl NNP cord-024189-t7mbsr25 1339 87 iximab iximab NNS cord-024189-t7mbsr25 1339 88 treatment treatment NN cord-024189-t7mbsr25 1339 89 for for IN cord-024189-t7mbsr25 1339 90 refractory refractory JJ cord-024189-t7mbsr25 1339 91 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1339 92 Syndrome Syndrome NNP cord-024189-t7mbsr25 1339 93 Infl Infl NNP cord-024189-t7mbsr25 1339 94 iximab iximab NNS cord-024189-t7mbsr25 1339 95 as as IN cord-024189-t7mbsr25 1339 96 a a DT cord-024189-t7mbsr25 1339 97 novel novel JJ cord-024189-t7mbsr25 1339 98 therapy therapy NN cord-024189-t7mbsr25 1339 99 for for IN cord-024189-t7mbsr25 1339 100 refractory refractory JJ cord-024189-t7mbsr25 1339 101 Kawasaki Kawasaki NNP cord-024189-t7mbsr25 1339 102 disease disease NN