id	sid	tid	token	lemma	pos
cord-356188-rwf78stz	1	1	key	key	JJ
cord-356188-rwf78stz	1	2	:	:	:
cord-356188-rwf78stz	1	3	cord-356188-rwf78stz	cord-356188-rwf78stz	NN
cord-356188-rwf78stz	1	4	authors	author	NNS
cord-356188-rwf78stz	1	5	:	:	:
cord-356188-rwf78stz	1	6	Oshansky	Oshansky	NNP
cord-356188-rwf78stz	1	7	,	,	,
cord-356188-rwf78stz	1	8	Christine	Christine	NNP
cord-356188-rwf78stz	1	9	M.	M.	NNP
cord-356188-rwf78stz	1	10	;	;	:
cord-356188-rwf78stz	1	11	Thomas	Thomas	NNP
cord-356188-rwf78stz	1	12	,	,	,
cord-356188-rwf78stz	2	1	Paul	Paul	NNP
cord-356188-rwf78stz	2	2	G.	G.	NNP
cord-356188-rwf78stz	2	3	title	title	NN
cord-356188-rwf78stz	2	4	:	:	:
cord-356188-rwf78stz	3	1	The	the	DT
cord-356188-rwf78stz	3	2	human	human	JJ
cord-356188-rwf78stz	3	3	side	side	NN
cord-356188-rwf78stz	3	4	of	of	IN
cord-356188-rwf78stz	3	5	influenza	influenza	NN
cord-356188-rwf78stz	3	6	date	date	NN
cord-356188-rwf78stz	3	7	:	:	:
cord-356188-rwf78stz	3	8	2012	2012	CD
cord-356188-rwf78stz	3	9	-	-	HYPH
cord-356188-rwf78stz	3	10	07	07	CD
cord-356188-rwf78stz	3	11	-	-	HYPH
cord-356188-rwf78stz	3	12	01	01	CD
cord-356188-rwf78stz	3	13	journal	journal	NN
cord-356188-rwf78stz	3	14	:	:	:
cord-356188-rwf78stz	3	15	Journal	Journal	NNP
cord-356188-rwf78stz	3	16	of	of	IN
cord-356188-rwf78stz	3	17	Leukocyte	Leukocyte	NNP
cord-356188-rwf78stz	3	18	Biology	Biology	NNP
cord-356188-rwf78stz	3	19	DOI	DOI	NNP
cord-356188-rwf78stz	3	20	:	:	:
cord-356188-rwf78stz	4	1	10.1189	10.1189	CD
cord-356188-rwf78stz	4	2	/	/	SYM
cord-356188-rwf78stz	4	3	jlb.1011506	jlb.1011506	NN
cord-356188-rwf78stz	5	1	sha	sha	NNP
cord-356188-rwf78stz	5	2	:	:	:
cord-356188-rwf78stz	6	1	0fe9f6cdebcd7c329eb7314d121b2cab28a3b15a	0fe9f6cdebcd7c329eb7314d121b2cab28a3b15a	NFP
cord-356188-rwf78stz	7	1	doc_id	doc_id	LS
cord-356188-rwf78stz	7	2	:	:	:
cord-356188-rwf78stz	7	3	356188	356188	CD
cord-356188-rwf78stz	7	4	cord_uid	cord_uid	NNS
cord-356188-rwf78stz	7	5	:	:	:
cord-356188-rwf78stz	7	6	rwf78stz	rwf78stz	NN
cord-356188-rwf78stz	8	1	A	a	DT
cord-356188-rwf78stz	8	2	clear	clear	JJ
cord-356188-rwf78stz	8	3	understanding	understanding	NN
cord-356188-rwf78stz	8	4	of	of	IN
cord-356188-rwf78stz	8	5	immunity	immunity	NN
cord-356188-rwf78stz	8	6	in	in	IN
cord-356188-rwf78stz	8	7	individuals	individual	NNS
cord-356188-rwf78stz	8	8	infected	infect	VBN
cord-356188-rwf78stz	8	9	with	with	IN
cord-356188-rwf78stz	8	10	influenza	influenza	NN
cord-356188-rwf78stz	8	11	virus	virus	NN
cord-356188-rwf78stz	8	12	is	be	VBZ
cord-356188-rwf78stz	8	13	critical	critical	JJ
cord-356188-rwf78stz	8	14	for	for	IN
cord-356188-rwf78stz	8	15	the	the	DT
cord-356188-rwf78stz	8	16	design	design	NN
cord-356188-rwf78stz	8	17	of	of	IN
cord-356188-rwf78stz	8	18	effective	effective	JJ
cord-356188-rwf78stz	8	19	vaccination	vaccination	NN
cord-356188-rwf78stz	8	20	and	and	CC
cord-356188-rwf78stz	8	21	treatment	treatment	NN
cord-356188-rwf78stz	8	22	strategies	strategy	NNS
cord-356188-rwf78stz	8	23	.	.	.
cord-356188-rwf78stz	9	1	Whereas	whereas	IN
cord-356188-rwf78stz	9	2	myriad	myriad	JJ
cord-356188-rwf78stz	9	3	studies	study	NNS
cord-356188-rwf78stz	9	4	have	have	VBP
cord-356188-rwf78stz	9	5	teased	tease	VBN
cord-356188-rwf78stz	9	6	apart	apart	RB
cord-356188-rwf78stz	9	7	innate	innate	JJ
cord-356188-rwf78stz	9	8	and	and	CC
cord-356188-rwf78stz	9	9	adaptive	adaptive	JJ
cord-356188-rwf78stz	9	10	immune	immune	JJ
cord-356188-rwf78stz	9	11	responses	response	NNS
cord-356188-rwf78stz	9	12	to	to	IN
cord-356188-rwf78stz	9	13	influenza	influenza	NN
cord-356188-rwf78stz	9	14	infection	infection	NN
cord-356188-rwf78stz	9	15	in	in	IN
cord-356188-rwf78stz	9	16	murine	murine	JJ
cord-356188-rwf78stz	9	17	models	model	NNS
cord-356188-rwf78stz	9	18	,	,	,
cord-356188-rwf78stz	9	19	much	much	RB
cord-356188-rwf78stz	9	20	less	less	JJR
cord-356188-rwf78stz	9	21	is	be	VBZ
cord-356188-rwf78stz	9	22	known	know	VBN
cord-356188-rwf78stz	9	23	about	about	IN
cord-356188-rwf78stz	9	24	human	human	JJ
cord-356188-rwf78stz	9	25	immunity	immunity	NN
cord-356188-rwf78stz	9	26	as	as	IN
cord-356188-rwf78stz	9	27	a	a	DT
cord-356188-rwf78stz	9	28	result	result	NN
cord-356188-rwf78stz	9	29	of	of	IN
cord-356188-rwf78stz	9	30	the	the	DT
cord-356188-rwf78stz	9	31	ethical	ethical	JJ
cord-356188-rwf78stz	9	32	and	and	CC
cord-356188-rwf78stz	9	33	technical	technical	JJ
cord-356188-rwf78stz	9	34	constraints	constraint	NNS
cord-356188-rwf78stz	9	35	of	of	IN
cord-356188-rwf78stz	9	36	human	human	JJ
cord-356188-rwf78stz	9	37	research	research	NN
cord-356188-rwf78stz	9	38	.	.	.
cord-356188-rwf78stz	10	1	Still	still	RB
cord-356188-rwf78stz	10	2	,	,	,
cord-356188-rwf78stz	10	3	these	these	DT
cord-356188-rwf78stz	10	4	murine	murine	JJ
cord-356188-rwf78stz	10	5	studies	study	NNS
cord-356188-rwf78stz	10	6	have	have	VBP
cord-356188-rwf78stz	10	7	provided	provide	VBN
cord-356188-rwf78stz	10	8	important	important	JJ
cord-356188-rwf78stz	10	9	insights	insight	NNS
cord-356188-rwf78stz	10	10	into	into	IN
cord-356188-rwf78stz	10	11	the	the	DT
cord-356188-rwf78stz	10	12	critical	critical	JJ
cord-356188-rwf78stz	10	13	correlates	correlate	NNS
cord-356188-rwf78stz	10	14	of	of	IN
cord-356188-rwf78stz	10	15	protection	protection	NN
cord-356188-rwf78stz	10	16	and	and	CC
cord-356188-rwf78stz	10	17	pathogenicity	pathogenicity	NN
cord-356188-rwf78stz	10	18	in	in	IN
cord-356188-rwf78stz	10	19	human	human	JJ
cord-356188-rwf78stz	10	20	infection	infection	NN
cord-356188-rwf78stz	10	21	and	and	CC
cord-356188-rwf78stz	10	22	helped	help	VBD
cord-356188-rwf78stz	10	23	direct	direct	VB
cord-356188-rwf78stz	10	24	the	the	DT
cord-356188-rwf78stz	10	25	human	human	JJ
cord-356188-rwf78stz	10	26	studies	study	NNS
cord-356188-rwf78stz	10	27	that	that	WDT
cord-356188-rwf78stz	10	28	have	have	VBP
cord-356188-rwf78stz	10	29	been	be	VBN
cord-356188-rwf78stz	10	30	conducted	conduct	VBN
cord-356188-rwf78stz	10	31	.	.	.
cord-356188-rwf78stz	11	1	Here	here	RB
cord-356188-rwf78stz	11	2	,	,	,
cord-356188-rwf78stz	11	3	we	-PRON-	PRP
cord-356188-rwf78stz	11	4	examine	examine	VBP
cord-356188-rwf78stz	11	5	and	and	CC
cord-356188-rwf78stz	11	6	review	review	VBP
cord-356188-rwf78stz	11	7	the	the	DT
cord-356188-rwf78stz	11	8	current	current	JJ
cord-356188-rwf78stz	11	9	literature	literature	NN
cord-356188-rwf78stz	11	10	on	on	IN
cord-356188-rwf78stz	11	11	immunity	immunity	NN
cord-356188-rwf78stz	11	12	in	in	IN
cord-356188-rwf78stz	11	13	humans	human	NNS
cord-356188-rwf78stz	11	14	infected	infect	VBN
cord-356188-rwf78stz	11	15	with	with	IN
cord-356188-rwf78stz	11	16	influenza	influenza	NN
cord-356188-rwf78stz	11	17	virus	virus	NN
cord-356188-rwf78stz	11	18	,	,	,
cord-356188-rwf78stz	11	19	noting	note	VBG
cord-356188-rwf78stz	11	20	evidence	evidence	NN
cord-356188-rwf78stz	11	21	offered	offer	VBN
cord-356188-rwf78stz	11	22	by	by	IN
cord-356188-rwf78stz	11	23	select	select	JJ
cord-356188-rwf78stz	11	24	murine	murine	JJ
cord-356188-rwf78stz	11	25	studies	study	NNS
cord-356188-rwf78stz	11	26	and	and	CC
cord-356188-rwf78stz	11	27	suggesting	suggest	VBG
cord-356188-rwf78stz	11	28	directions	direction	NNS
cord-356188-rwf78stz	11	29	in	in	IN
cord-356188-rwf78stz	11	30	which	which	WDT
cord-356188-rwf78stz	11	31	future	future	JJ
cord-356188-rwf78stz	11	32	research	research	NN
cord-356188-rwf78stz	11	33	is	be	VBZ
cord-356188-rwf78stz	11	34	most	most	RBS
cord-356188-rwf78stz	11	35	warranted	warranted	JJ
cord-356188-rwf78stz	11	36	.	.	.
cord-356188-rwf78stz	12	1	Influenza	influenza	NN
cord-356188-rwf78stz	12	2	infection	infection	NN
cord-356188-rwf78stz	12	3	in	in	IN
cord-356188-rwf78stz	12	4	humans	human	NNS
cord-356188-rwf78stz	12	5	can	can	MD
cord-356188-rwf78stz	12	6	cause	cause	VB
cord-356188-rwf78stz	12	7	a	a	DT
cord-356188-rwf78stz	12	8	wide	wide	JJ
cord-356188-rwf78stz	12	9	range	range	NN
cord-356188-rwf78stz	12	10	of	of	IN
cord-356188-rwf78stz	12	11	disease	disease	NN
cord-356188-rwf78stz	12	12	symptoms	symptom	NNS
cord-356188-rwf78stz	12	13	,	,	,
cord-356188-rwf78stz	12	14	from	from	IN
cord-356188-rwf78stz	12	15	asymptomatic	asymptomatic	JJ
cord-356188-rwf78stz	12	16	to	to	IN
cord-356188-rwf78stz	12	17	serious	serious	JJ
cord-356188-rwf78stz	12	18	illness	illness	NN
cord-356188-rwf78stz	12	19	,	,	,
cord-356188-rwf78stz	12	20	characterized	characterize	VBN
cord-356188-rwf78stz	12	21	by	by	IN
cord-356188-rwf78stz	12	22	sudden	sudden	JJ
cord-356188-rwf78stz	12	23	onset	onset	NN
cord-356188-rwf78stz	12	24	of	of	IN
cord-356188-rwf78stz	12	25	fever	fever	NN
cord-356188-rwf78stz	12	26	,	,	,
cord-356188-rwf78stz	12	27	myalgia	myalgia	NN
cord-356188-rwf78stz	12	28	,	,	,
cord-356188-rwf78stz	12	29	and	and	CC
cord-356188-rwf78stz	12	30	respiratory	respiratory	JJ
cord-356188-rwf78stz	12	31	indications	indication	NNS
cord-356188-rwf78stz	12	32	,	,	,
cord-356188-rwf78stz	12	33	including	include	VBG
cord-356188-rwf78stz	12	34	nonproductive	nonproductive	JJ
cord-356188-rwf78stz	12	35	cough	cough	NN
cord-356188-rwf78stz	12	36	,	,	,
cord-356188-rwf78stz	12	37	sore	sore	JJ
cord-356188-rwf78stz	12	38	throat	throat	NN
cord-356188-rwf78stz	12	39	,	,	,
cord-356188-rwf78stz	12	40	and	and	CC
cord-356188-rwf78stz	12	41	rhinitis	rhinitis	NN
cord-356188-rwf78stz	12	42	.	.	.
cord-356188-rwf78stz	13	1	In	in	IN
cord-356188-rwf78stz	13	2	addition	addition	NN
cord-356188-rwf78stz	13	3	,	,	,
cord-356188-rwf78stz	13	4	children	child	NNS
cord-356188-rwf78stz	13	5	infected	infect	VBN
cord-356188-rwf78stz	13	6	with	with	IN
cord-356188-rwf78stz	13	7	influenza	influenza	NN
cord-356188-rwf78stz	13	8	commonly	commonly	RB
cord-356188-rwf78stz	13	9	present	present	JJ
cord-356188-rwf78stz	13	10	with	with	IN
cord-356188-rwf78stz	13	11	otitis	otitis	NN
cord-356188-rwf78stz	13	12	media	medium	NNS
cord-356188-rwf78stz	13	13	,	,	,
cord-356188-rwf78stz	13	14	nausea	nausea	NN
cord-356188-rwf78stz	13	15	,	,	,
cord-356188-rwf78stz	13	16	and	and	CC
cord-356188-rwf78stz	13	17	vomiting	vomit	VBG
cord-356188-rwf78stz	13	18	and	and	CC
cord-356188-rwf78stz	13	19	more	more	RBR
cord-356188-rwf78stz	13	20	frequently	frequently	RB
cord-356188-rwf78stz	13	21	,	,	,
cord-356188-rwf78stz	13	22	complain	complain	VBP
cord-356188-rwf78stz	13	23	of	of	IN
cord-356188-rwf78stz	13	24	rhinorrhea	rhinorrhea	NNP
cord-356188-rwf78stz	13	25	[	[	-LRB-
cord-356188-rwf78stz	13	26	1	1	CD
cord-356188-rwf78stz	13	27	,	,	,
cord-356188-rwf78stz	13	28	2	2	CD
cord-356188-rwf78stz	13	29	]	]	-RRB-
cord-356188-rwf78stz	13	30	.	.	.
cord-356188-rwf78stz	14	1	Historically	historically	RB
cord-356188-rwf78stz	14	2	,	,	,
cord-356188-rwf78stz	14	3	the	the	DT
cord-356188-rwf78stz	14	4	pediatric	pediatric	JJ
cord-356188-rwf78stz	14	5	and	and	CC
cord-356188-rwf78stz	14	6	elderly	elderly	JJ
cord-356188-rwf78stz	14	7	populations	population	NNS
cord-356188-rwf78stz	14	8	are	be	VBP
cord-356188-rwf78stz	14	9	considered	consider	VBN
cord-356188-rwf78stz	14	10	vulnerable	vulnerable	JJ
cord-356188-rwf78stz	14	11	during	during	IN
cord-356188-rwf78stz	14	12	influenza	influenza	NN
cord-356188-rwf78stz	14	13	epidemics	epidemic	NNS
cord-356188-rwf78stz	14	14	[	[	-LRB-
cord-356188-rwf78stz	14	15	3	3	CD
cord-356188-rwf78stz	14	16	]	]	-RRB-
cord-356188-rwf78stz	14	17	[	[	-LRB-
cord-356188-rwf78stz	14	18	4	4	CD
cord-356188-rwf78stz	14	19	]	]	-RRB-
cord-356188-rwf78stz	14	20	[	[	-LRB-
cord-356188-rwf78stz	14	21	5	5	CD
cord-356188-rwf78stz	14	22	]	]	-RRB-
cord-356188-rwf78stz	14	23	[	[	-LRB-
cord-356188-rwf78stz	14	24	6	6	CD
cord-356188-rwf78stz	14	25	]	]	-RRB-
cord-356188-rwf78stz	14	26	,	,	,
cord-356188-rwf78stz	14	27	and	and	CC
cord-356188-rwf78stz	14	28	although	although	IN
cord-356188-rwf78stz	14	29	still	still	RB
cord-356188-rwf78stz	14	30	debated	debate	VBN
cord-356188-rwf78stz	14	31	,	,	,
cord-356188-rwf78stz	14	32	studies	study	NNS
cord-356188-rwf78stz	14	33	suggest	suggest	VBP
cord-356188-rwf78stz	14	34	that	that	IN
cord-356188-rwf78stz	14	35	children	child	NNS
cord-356188-rwf78stz	14	36	have	have	VBP
cord-356188-rwf78stz	14	37	a	a	DT
cord-356188-rwf78stz	14	38	unique	unique	JJ
cord-356188-rwf78stz	14	39	role	role	NN
cord-356188-rwf78stz	14	40	in	in	IN
cord-356188-rwf78stz	14	41	the	the	DT
cord-356188-rwf78stz	14	42	spread	spread	NN
cord-356188-rwf78stz	14	43	of	of	IN
cord-356188-rwf78stz	14	44	influenza	influenza	NN
cord-356188-rwf78stz	14	45	during	during	IN
cord-356188-rwf78stz	14	46	epidemics	epidemic	NNS
cord-356188-rwf78stz	14	47	[	[	-LRB-
cord-356188-rwf78stz	14	48	7	7	CD
cord-356188-rwf78stz	14	49	]	]	-RRB-
cord-356188-rwf78stz	14	50	[	[	-LRB-
cord-356188-rwf78stz	14	51	8	8	CD
cord-356188-rwf78stz	14	52	]	]	-RRB-
cord-356188-rwf78stz	14	53	[	[	-LRB-
cord-356188-rwf78stz	14	54	9	9	CD
cord-356188-rwf78stz	14	55	]	]	-RRB-
cord-356188-rwf78stz	14	56	.	.	.
cord-356188-rwf78stz	15	1	Children	child	NNS
cord-356188-rwf78stz	15	2	under	under	IN
cord-356188-rwf78stz	15	3	2	2	CD
cord-356188-rwf78stz	15	4	years	year	NNS
cord-356188-rwf78stz	15	5	old	old	JJ
cord-356188-rwf78stz	15	6	are	be	VBP
cord-356188-rwf78stz	15	7	more	more	RBR
cord-356188-rwf78stz	15	8	susceptible	susceptible	JJ
cord-356188-rwf78stz	15	9	to	to	IN
cord-356188-rwf78stz	15	10	secondary	secondary	JJ
cord-356188-rwf78stz	15	11	complications	complication	NNS
cord-356188-rwf78stz	15	12	[	[	-LRB-
cord-356188-rwf78stz	15	13	10	10	CD
cord-356188-rwf78stz	15	14	]	]	-RRB-
cord-356188-rwf78stz	15	15	,	,	,
cord-356188-rwf78stz	15	16	and	and	CC
cord-356188-rwf78stz	15	17	infants	infant	NNS
cord-356188-rwf78stz	15	18	with	with	IN
cord-356188-rwf78stz	15	19	severe	severe	JJ
cord-356188-rwf78stz	15	20	respiratory	respiratory	JJ
cord-356188-rwf78stz	15	21	tract	tract	NN
cord-356188-rwf78stz	15	22	viral	viral	JJ
cord-356188-rwf78stz	15	23	infection	infection	NN
cord-356188-rwf78stz	15	24	are	be	VBP
cord-356188-rwf78stz	15	25	often	often	RB
cord-356188-rwf78stz	15	26	at	at	IN
cord-356188-rwf78stz	15	27	greater	great	JJR
cord-356188-rwf78stz	15	28	danger	danger	NN
cord-356188-rwf78stz	15	29	for	for	IN
cord-356188-rwf78stz	15	30	pulmonary	pulmonary	JJ
cord-356188-rwf78stz	15	31	dysfunction	dysfunction	NN
cord-356188-rwf78stz	15	32	,	,	,
cord-356188-rwf78stz	15	33	including	include	VBG
cord-356188-rwf78stz	15	34	wheezing	wheeze	VBG
cord-356188-rwf78stz	15	35	,	,	,
cord-356188-rwf78stz	15	36	allergy	allergy	NN
cord-356188-rwf78stz	15	37	,	,	,
cord-356188-rwf78stz	15	38	and	and	CC
cord-356188-rwf78stz	15	39	asthma	asthma	NN
cord-356188-rwf78stz	15	40	later	later	RB
cord-356188-rwf78stz	15	41	in	in	IN
cord-356188-rwf78stz	15	42	life	life	NN
cord-356188-rwf78stz	15	43	[	[	-LRB-
cord-356188-rwf78stz	15	44	11	11	CD
cord-356188-rwf78stz	15	45	]	]	-RRB-
cord-356188-rwf78stz	15	46	[	[	-LRB-
cord-356188-rwf78stz	15	47	12	12	CD
cord-356188-rwf78stz	15	48	]	]	-RRB-
cord-356188-rwf78stz	15	49	[	[	-LRB-
cord-356188-rwf78stz	15	50	13	13	CD
cord-356188-rwf78stz	15	51	]	]	-RRB-
cord-356188-rwf78stz	15	52	.	.	.
cord-356188-rwf78stz	16	1	In	in	IN
cord-356188-rwf78stz	16	2	contrast	contrast	NN
cord-356188-rwf78stz	16	3	,	,	,
cord-356188-rwf78stz	16	4	elderly	elderly	JJ
cord-356188-rwf78stz	16	5	individuals	individual	NNS
cord-356188-rwf78stz	16	6	are	be	VBP
cord-356188-rwf78stz	16	7	at	at	IN
cord-356188-rwf78stz	16	8	higher	high	JJR
cord-356188-rwf78stz	16	9	risk	risk	NN
cord-356188-rwf78stz	16	10	for	for	IN
cord-356188-rwf78stz	16	11	developing	develop	VBG
cord-356188-rwf78stz	16	12	hemorrhagic	hemorrhagic	JJ
cord-356188-rwf78stz	16	13	bronchitis	bronchitis	NN
cord-356188-rwf78stz	16	14	,	,	,
cord-356188-rwf78stz	16	15	pneumonia	pneumonia	NN
cord-356188-rwf78stz	16	16	,	,	,
cord-356188-rwf78stz	16	17	and	and	CC
cord-356188-rwf78stz	16	18	death	death	NN
cord-356188-rwf78stz	16	19	when	when	WRB
cord-356188-rwf78stz	16	20	infected	infect	VBN
cord-356188-rwf78stz	16	21	with	with	IN
cord-356188-rwf78stz	16	22	influenza	influenza	NN
cord-356188-rwf78stz	16	23	[	[	-LRB-
cord-356188-rwf78stz	16	24	14	14	CD
cord-356188-rwf78stz	16	25	]	]	-RRB-
cord-356188-rwf78stz	16	26	,	,	,
cord-356188-rwf78stz	16	27	and	and	CC
cord-356188-rwf78stz	16	28	this	this	DT
cord-356188-rwf78stz	16	29	population	population	NN
cord-356188-rwf78stz	16	30	generally	generally	RB
cord-356188-rwf78stz	16	31	has	have	VBZ
cord-356188-rwf78stz	16	32	a	a	DT
cord-356188-rwf78stz	16	33	less	less	RBR
cord-356188-rwf78stz	16	34	-	-	HYPH
cord-356188-rwf78stz	16	35	robust	robust	JJ
cord-356188-rwf78stz	16	36	immune	immune	JJ
cord-356188-rwf78stz	16	37	response	response	NN
cord-356188-rwf78stz	16	38	following	follow	VBG
cord-356188-rwf78stz	16	39	influenza	influenza	NN
cord-356188-rwf78stz	16	40	immunization	immunization	NN
cord-356188-rwf78stz	16	41	.	.	.
cord-356188-rwf78stz	17	1	Although	although	IN
cord-356188-rwf78stz	17	2	RSV	RSV	NNP
cord-356188-rwf78stz	17	3	infections	infection	NNS
cord-356188-rwf78stz	17	4	are	be	VBP
cord-356188-rwf78stz	17	5	the	the	DT
cord-356188-rwf78stz	17	6	leading	leading	JJ
cord-356188-rwf78stz	17	7	cause	cause	NN
cord-356188-rwf78stz	17	8	of	of	IN
cord-356188-rwf78stz	17	9	hospitalizations	hospitalization	NNS
cord-356188-rwf78stz	17	10	of	of	IN
cord-356188-rwf78stz	17	11	children	child	NNS
cord-356188-rwf78stz	17	12	in	in	IN
cord-356188-rwf78stz	17	13	the	the	DT
cord-356188-rwf78stz	17	14	United	United	NNP
cord-356188-rwf78stz	17	15	States	States	NNP
cord-356188-rwf78stz	17	16	,	,	,
cord-356188-rwf78stz	17	17	influenza	influenza	NN
cord-356188-rwf78stz	17	18	accounts	account	VBZ
cord-356188-rwf78stz	17	19	for	for	IN
cord-356188-rwf78stz	17	20	the	the	DT
cord-356188-rwf78stz	17	21	highest	high	JJS
cord-356188-rwf78stz	17	22	incidence	incidence	NN
cord-356188-rwf78stz	17	23	of	of	IN
cord-356188-rwf78stz	17	24	infection	infection	NN
cord-356188-rwf78stz	17	25	in	in	IN
cord-356188-rwf78stz	17	26	children	child	NNS
cord-356188-rwf78stz	17	27	under	under	IN
cord-356188-rwf78stz	17	28	2	2	CD
cord-356188-rwf78stz	17	29	years	year	NNS
cord-356188-rwf78stz	17	30	of	of	IN
cord-356188-rwf78stz	17	31	age	age	NN
cord-356188-rwf78stz	17	32	[	[	-LRB-
cord-356188-rwf78stz	17	33	15	15	CD
cord-356188-rwf78stz	17	34	]	]	-RRB-
cord-356188-rwf78stz	17	35	.	.	.
cord-356188-rwf78stz	18	1	Influenza	influenza	NN
cord-356188-rwf78stz	18	2	epidemics	epidemic	NNS
cord-356188-rwf78stz	18	3	occur	occur	VBP
cord-356188-rwf78stz	18	4	annually	annually	RB
cord-356188-rwf78stz	18	5	and	and	CC
cord-356188-rwf78stz	18	6	can	can	MD
cord-356188-rwf78stz	18	7	cause	cause	VB
cord-356188-rwf78stz	18	8	significant	significant	JJ
cord-356188-rwf78stz	18	9	morbidity	morbidity	NN
cord-356188-rwf78stz	18	10	and	and	CC
cord-356188-rwf78stz	18	11	mortality	mortality	NN
cord-356188-rwf78stz	18	12	worldwide	worldwide	RB
cord-356188-rwf78stz	18	13	.	.	.
cord-356188-rwf78stz	19	1	During	during	IN
cord-356188-rwf78stz	19	2	1976	1976	CD
cord-356188-rwf78stz	19	3	-2007	-2007	NN
cord-356188-rwf78stz	19	4	,	,	,
cord-356188-rwf78stz	19	5	the	the	DT
cord-356188-rwf78stz	19	6	CDC	CDC	NNP
cord-356188-rwf78stz	19	7	estimated	estimate	VBD
cord-356188-rwf78stz	19	8	that	that	IN
cord-356188-rwf78stz	19	9	in	in	IN
cord-356188-rwf78stz	19	10	the	the	DT
cord-356188-rwf78stz	19	11	United	United	NNP
cord-356188-rwf78stz	19	12	States	States	NNP
cord-356188-rwf78stz	19	13	alone	alone	RB
cord-356188-rwf78stz	19	14	,	,	,
cord-356188-rwf78stz	19	15	annually	annually	RB
cord-356188-rwf78stz	19	16	,	,	,
cord-356188-rwf78stz	19	17	8.5	8.5	CD
cord-356188-rwf78stz	19	18	%	%	NN
cord-356188-rwf78stz	19	19	(	(	-LRB-
cord-356188-rwf78stz	19	20	6309	6309	CD
cord-356188-rwf78stz	19	21	)	)	-RRB-
cord-356188-rwf78stz	19	22	of	of	IN
cord-356188-rwf78stz	19	23	all	all	DT
cord-356188-rwf78stz	19	24	"	"	``
cord-356188-rwf78stz	19	25	deaths	death	NNS
cord-356188-rwf78stz	19	26	with	with	IN
cord-356188-rwf78stz	19	27	underlying	underlie	VBG
cord-356188-rwf78stz	19	28	pneumonia	pneumonia	NN
cord-356188-rwf78stz	19	29	and	and	CC
cord-356188-rwf78stz	19	30	influenza	influenza	NN
cord-356188-rwf78stz	19	31	causes	cause	NNS
cord-356188-rwf78stz	19	32	"	"	''
cord-356188-rwf78stz	19	33	(	(	-LRB-
cord-356188-rwf78stz	19	34	74	74	CD
cord-356188-rwf78stz	19	35	,	,	,
cord-356188-rwf78stz	19	36	363	363	CD
cord-356188-rwf78stz	19	37	)	)	-RRB-
cord-356188-rwf78stz	19	38	were	be	VBD
cord-356188-rwf78stz	19	39	influenza	influenza	NN
cord-356188-rwf78stz	19	40	-	-	HYPH
cord-356188-rwf78stz	19	41	associated	associate	VBN
cord-356188-rwf78stz	19	42	,	,	,
cord-356188-rwf78stz	19	43	and	and	CC
cord-356188-rwf78stz	19	44	2.1	2.1	CD
cord-356188-rwf78stz	19	45	%	%	NN
cord-356188-rwf78stz	19	46	(	(	-LRB-
cord-356188-rwf78stz	19	47	23	23	CD
cord-356188-rwf78stz	19	48	,	,	,
cord-356188-rwf78stz	19	49	607	607	CD
cord-356188-rwf78stz	19	50	)	)	-RRB-
cord-356188-rwf78stz	19	51	of	of	IN
cord-356188-rwf78stz	19	52	"	"	``
cord-356188-rwf78stz	19	53	deaths	death	NNS
cord-356188-rwf78stz	19	54	with	with	IN
cord-356188-rwf78stz	19	55	underlying	underlie	VBG
cord-356188-rwf78stz	19	56	respiratory	respiratory	JJ
cord-356188-rwf78stz	19	57	and	and	CC
cord-356188-rwf78stz	19	58	circulatory	circulatory	JJ
cord-356188-rwf78stz	19	59	causes	cause	NNS
cord-356188-rwf78stz	19	60	"	"	''
cord-356188-rwf78stz	19	61	(	(	-LRB-
cord-356188-rwf78stz	19	62	1,132,319	1,132,319	CD
cord-356188-rwf78stz	19	63	)	)	-RRB-
cord-356188-rwf78stz	19	64	were	be	VBD
cord-356188-rwf78stz	19	65	influenza	influenza	NN
cord-356188-rwf78stz	19	66	-	-	HYPH
cord-356188-rwf78stz	19	67	associated	associate	VBN
cord-356188-rwf78stz	19	68	[	[	-LRB-
cord-356188-rwf78stz	19	69	16	16	CD
cord-356188-rwf78stz	19	70	]	]	-RRB-
cord-356188-rwf78stz	19	71	.	.	.
cord-356188-rwf78stz	20	1	Furthermore	furthermore	RB
cord-356188-rwf78stz	20	2	,	,	,
cord-356188-rwf78stz	20	3	individuals	individual	NNS
cord-356188-rwf78stz	20	4	with	with	IN
cord-356188-rwf78stz	20	5	underlying	underlie	VBG
cord-356188-rwf78stz	20	6	respiratory	respiratory	JJ
cord-356188-rwf78stz	20	7	and	and	CC
cord-356188-rwf78stz	20	8	cardiac	cardiac	JJ
cord-356188-rwf78stz	20	9	disease	disease	NN
cord-356188-rwf78stz	20	10	or	or	CC
cord-356188-rwf78stz	20	11	diabetes	diabetes	NN
cord-356188-rwf78stz	20	12	mellitis	mellitis	NNP
cord-356188-rwf78stz	20	13	,	,	,
cord-356188-rwf78stz	20	14	infected	infect	VBN
cord-356188-rwf78stz	20	15	with	with	IN
cord-356188-rwf78stz	20	16	influenza	influenza	NN
cord-356188-rwf78stz	20	17	,	,	,
cord-356188-rwf78stz	20	18	are	be	VBP
cord-356188-rwf78stz	20	19	often	often	RB
cord-356188-rwf78stz	20	20	at	at	IN
cord-356188-rwf78stz	20	21	higher	high	JJR
cord-356188-rwf78stz	20	22	risk	risk	NN
cord-356188-rwf78stz	20	23	for	for	IN
cord-356188-rwf78stz	20	24	developing	develop	VBG
cord-356188-rwf78stz	20	25	hemorrhagic	hemorrhagic	JJ
cord-356188-rwf78stz	20	26	bronchitis	bronchitis	NN
cord-356188-rwf78stz	20	27	or	or	CC
cord-356188-rwf78stz	20	28	pneumonia	pneumonia	NN
cord-356188-rwf78stz	20	29	and	and	CC
cord-356188-rwf78stz	20	30	associated	associated	JJ
cord-356188-rwf78stz	20	31	comorbidities	comorbiditie	NNS
cord-356188-rwf78stz	20	32	.	.	.
cord-356188-rwf78stz	21	1	In	in	IN
cord-356188-rwf78stz	21	2	2008	2008	CD
cord-356188-rwf78stz	21	3	,	,	,
cord-356188-rwf78stz	21	4	it	-PRON-	PRP
cord-356188-rwf78stz	21	5	was	be	VBD
cord-356188-rwf78stz	21	6	estimated	estimate	VBN
cord-356188-rwf78stz	21	7	that	that	IN
cord-356188-rwf78stz	21	8	there	there	EX
cord-356188-rwf78stz	21	9	were	be	VBD
cord-356188-rwf78stz	21	10	28,000	28,000	CD
cord-356188-rwf78stz	21	11	-111,500	-111,500	:
cord-356188-rwf78stz	21	12	deaths	death	NNS
cord-356188-rwf78stz	21	13	attributable	attributable	JJ
cord-356188-rwf78stz	21	14	to	to	IN
cord-356188-rwf78stz	21	15	influenza	influenza	NN
cord-356188-rwf78stz	21	16	in	in	IN
cord-356188-rwf78stz	21	17	children	child	NNS
cord-356188-rwf78stz	21	18	Ͻ5	ͻ5	CD
cord-356188-rwf78stz	21	19	years	year	NNS
cord-356188-rwf78stz	21	20	of	of	IN
cord-356188-rwf78stz	21	21	age	age	NN
cord-356188-rwf78stz	21	22	globally	globally	RB
cord-356188-rwf78stz	21	23	,	,	,
cord-356188-rwf78stz	21	24	with	with	IN
cord-356188-rwf78stz	21	25	developing	develop	VBG
cord-356188-rwf78stz	21	26	countries	country	NNS
cord-356188-rwf78stz	21	27	carrying	carry	VBG
cord-356188-rwf78stz	21	28	the	the	DT
cord-356188-rwf78stz	21	29	largest	large	JJS
cord-356188-rwf78stz	21	30	burden	burden	NN
cord-356188-rwf78stz	21	31	[	[	-LRB-
cord-356188-rwf78stz	21	32	17	17	CD
cord-356188-rwf78stz	21	33	]	]	-RRB-
cord-356188-rwf78stz	21	34	.	.	.
cord-356188-rwf78stz	22	1	In	in	IN
cord-356188-rwf78stz	22	2	the	the	DT
cord-356188-rwf78stz	22	3	United	United	NNP
cord-356188-rwf78stz	22	4	States	States	NNP
cord-356188-rwf78stz	22	5	,	,	,
cord-356188-rwf78stz	22	6	annual	annual	JJ
cord-356188-rwf78stz	22	7	influenza	influenza	NN
cord-356188-rwf78stz	22	8	epidemics	epidemic	NNS
cord-356188-rwf78stz	22	9	account	account	VBP
cord-356188-rwf78stz	22	10	for	for	IN
cord-356188-rwf78stz	22	11	an	an	DT
cord-356188-rwf78stz	22	12	estimated	estimate	VBN
cord-356188-rwf78stz	22	13	$	$	$
cord-356188-rwf78stz	22	14	10	10	CD
cord-356188-rwf78stz	22	15	billion	billion	CD
cord-356188-rwf78stz	22	16	(	(	-LRB-
cord-356188-rwf78stz	22	17	12	12	CD
cord-356188-rwf78stz	22	18	%	%	NN
cord-356188-rwf78stz	22	19	of	of	IN
cord-356188-rwf78stz	22	20	the	the	DT
cord-356188-rwf78stz	22	21	total	total	JJ
cord-356188-rwf78stz	22	22	economic	economic	JJ
cord-356188-rwf78stz	22	23	burden	burden	NN
cord-356188-rwf78stz	22	24	)	)	-RRB-
cord-356188-rwf78stz	22	25	in	in	IN
cord-356188-rwf78stz	22	26	direct	direct	JJ
cord-356188-rwf78stz	22	27	medical	medical	JJ
cord-356188-rwf78stz	22	28	costs	cost	NNS
cord-356188-rwf78stz	22	29	[	[	-LRB-
cord-356188-rwf78stz	22	30	18	18	CD
cord-356188-rwf78stz	22	31	]	]	-RRB-
cord-356188-rwf78stz	22	32	and	and	CC
cord-356188-rwf78stz	22	33	an	an	DT
cord-356188-rwf78stz	22	34	estimated	estimated	JJ
cord-356188-rwf78stz	22	35	$	$	$
cord-356188-rwf78stz	22	36	44	44	CD
cord-356188-rwf78stz	22	37	-$163	-$163	CD
cord-356188-rwf78stz	22	38	million	million	CD
cord-356188-rwf78stz	22	39	in	in	IN
cord-356188-rwf78stz	22	40	hospitalization	hospitalization	NN
cord-356188-rwf78stz	22	41	costs	cost	NNS
cord-356188-rwf78stz	22	42	for	for	IN
cord-356188-rwf78stz	22	43	children	child	NNS
cord-356188-rwf78stz	22	44	[	[	-LRB-
cord-356188-rwf78stz	22	45	19	19	CD
cord-356188-rwf78stz	22	46	]	]	-RRB-
cord-356188-rwf78stz	22	47	.	.	.
cord-356188-rwf78stz	23	1	Introduction	introduction	NN
cord-356188-rwf78stz	23	2	of	of	IN
cord-356188-rwf78stz	23	3	a	a	DT
cord-356188-rwf78stz	23	4	swine	swine	NN
cord-356188-rwf78stz	23	5	-	-	HYPH
cord-356188-rwf78stz	23	6	origin	origin	NN
cord-356188-rwf78stz	23	7	influenza	influenza	NN
cord-356188-rwf78stz	23	8	into	into	IN
cord-356188-rwf78stz	23	9	the	the	DT
cord-356188-rwf78stz	23	10	human	human	JJ
cord-356188-rwf78stz	23	11	population	population	NN
cord-356188-rwf78stz	23	12	in	in	IN
cord-356188-rwf78stz	23	13	2009	2009	CD
cord-356188-rwf78stz	23	14	quickly	quickly	RB
cord-356188-rwf78stz	23	15	disseminated	disseminate	VBD
cord-356188-rwf78stz	23	16	globally	globally	RB
cord-356188-rwf78stz	23	17	,	,	,
cord-356188-rwf78stz	23	18	causing	cause	VBG
cord-356188-rwf78stz	23	19	the	the	DT
cord-356188-rwf78stz	23	20	first	first	JJ
cord-356188-rwf78stz	23	21	pandemic	pandemic	NN
cord-356188-rwf78stz	23	22	of	of	IN
cord-356188-rwf78stz	23	23	the	the	DT
cord-356188-rwf78stz	23	24	21st	21st	JJ
cord-356188-rwf78stz	23	25	century	century	NN
cord-356188-rwf78stz	23	26	.	.	.
cord-356188-rwf78stz	24	1	This	this	DT
cord-356188-rwf78stz	24	2	novel	novel	NN
cord-356188-rwf78stz	24	3	H1N1	H1N1	NNP
cord-356188-rwf78stz	24	4	virus	virus	NN
cord-356188-rwf78stz	24	5	,	,	,
cord-356188-rwf78stz	24	6	hereafter	hereafter	RB
cord-356188-rwf78stz	24	7	referred	refer	VBD
cord-356188-rwf78stz	24	8	to	to	IN
cord-356188-rwf78stz	24	9	as	as	IN
cord-356188-rwf78stz	24	10	A(H1N1)pdm09	A(H1N1)pdm09	NNP
cord-356188-rwf78stz	24	11	[	[	-LRB-
cord-356188-rwf78stz	24	12	20	20	CD
cord-356188-rwf78stz	24	13	]	]	-RRB-
cord-356188-rwf78stz	24	14	,	,	,
cord-356188-rwf78stz	24	15	disproportionately	disproportionately	RB
cord-356188-rwf78stz	24	16	affected	affect	VBN
cord-356188-rwf78stz	24	17	children	child	NNS
cord-356188-rwf78stz	24	18	and	and	CC
cord-356188-rwf78stz	24	19	young	young	JJ
cord-356188-rwf78stz	24	20	adults	adult	NNS
cord-356188-rwf78stz	24	21	[	[	-LRB-
cord-356188-rwf78stz	24	22	21	21	CD
cord-356188-rwf78stz	24	23	,	,	,
cord-356188-rwf78stz	24	24	22	22	CD
cord-356188-rwf78stz	24	25	]	]	-RRB-
cord-356188-rwf78stz	24	26	.	.	.
cord-356188-rwf78stz	25	1	Observed	observe	VBN
cord-356188-rwf78stz	25	2	mortality	mortality	NN
cord-356188-rwf78stz	25	3	increased	increase	VBD
cord-356188-rwf78stz	25	4	between	between	IN
cord-356188-rwf78stz	25	5	four	four	CD
cord-356188-rwf78stz	25	6	and	and	CC
cord-356188-rwf78stz	25	7	10	10	CD
cord-356188-rwf78stz	25	8	times	time	NNS
cord-356188-rwf78stz	25	9	in	in	IN
cord-356188-rwf78stz	25	10	the	the	DT
cord-356188-rwf78stz	25	11	pediatric	pediatric	JJ
cord-356188-rwf78stz	25	12	population	population	NN
cord-356188-rwf78stz	25	13	during	during	IN
cord-356188-rwf78stz	25	14	the	the	DT
cord-356188-rwf78stz	25	15	initial	initial	JJ
cord-356188-rwf78stz	25	16	wave	wave	NN
cord-356188-rwf78stz	25	17	of	of	IN
cord-356188-rwf78stz	25	18	A(H1N1)pdm09	A(H1N1)pdm09	NNP
cord-356188-rwf78stz	25	19	infection	infection	NN
cord-356188-rwf78stz	25	20	in	in	IN
cord-356188-rwf78stz	25	21	2009	2009	CD
cord-356188-rwf78stz	25	22	compared	compare	VBN
cord-356188-rwf78stz	25	23	with	with	IN
cord-356188-rwf78stz	25	24	previous	previous	JJ
cord-356188-rwf78stz	25	25	influenza	influenza	NN
cord-356188-rwf78stz	25	26	seasons	season	NNS
cord-356188-rwf78stz	25	27	[	[	-LRB-
cord-356188-rwf78stz	25	28	23	23	CD
cord-356188-rwf78stz	25	29	]	]	-RRB-
cord-356188-rwf78stz	25	30	,	,	,
cord-356188-rwf78stz	25	31	whereas	whereas	IN
cord-356188-rwf78stz	25	32	those	those	DT
cord-356188-rwf78stz	25	33	individuals	individual	NNS
cord-356188-rwf78stz	25	34	born	bear	VBN
cord-356188-rwf78stz	25	35	prior	prior	RB
cord-356188-rwf78stz	25	36	to	to	IN
cord-356188-rwf78stz	25	37	1950	1950	CD
cord-356188-rwf78stz	25	38	had	have	VBD
cord-356188-rwf78stz	25	39	pre	pre	VBN
cord-356188-rwf78stz	25	40	-	-	JJ
cord-356188-rwf78stz	25	41	existing	existing	JJ
cord-356188-rwf78stz	25	42	,	,	,
cord-356188-rwf78stz	25	43	cross	cross	JJ
cord-356188-rwf78stz	25	44	-	-	JJ
cord-356188-rwf78stz	25	45	reactive	reactive	JJ
cord-356188-rwf78stz	25	46	antibodies	antibody	NNS
cord-356188-rwf78stz	25	47	against	against	IN
cord-356188-rwf78stz	25	48	A(H1N1)pdm09	A(H1N1)pdm09	NNP
cord-356188-rwf78stz	25	49	[	[	-LRB-
cord-356188-rwf78stz	25	50	24	24	CD
cord-356188-rwf78stz	25	51	]	]	-RRB-
cord-356188-rwf78stz	25	52	.	.	.
cord-356188-rwf78stz	26	1	As	as	IN
cord-356188-rwf78stz	26	2	a	a	DT
cord-356188-rwf78stz	26	3	result	result	NN
cord-356188-rwf78stz	26	4	,	,	,
cord-356188-rwf78stz	26	5	within	within	IN
cord-356188-rwf78stz	26	6	the	the	DT
cord-356188-rwf78stz	26	7	population	population	NN
cord-356188-rwf78stz	26	8	of	of	IN
cord-356188-rwf78stz	26	9	those	those	DT
cord-356188-rwf78stz	26	10	with	with	IN
cord-356188-rwf78stz	26	11	laboratory	laboratory	NN
cord-356188-rwf78stz	26	12	-	-	HYPH
cord-356188-rwf78stz	26	13	confirmed	confirm	VBN
cord-356188-rwf78stz	26	14	A(H1N1)pdm09	A(H1N1)pdm09	NNP
cord-356188-rwf78stz	26	15	,	,	,
cord-356188-rwf78stz	26	16	2	2	CD
cord-356188-rwf78stz	26	17	%	%	NN
cord-356188-rwf78stz	26	18	were	be	VBD
cord-356188-rwf78stz	26	19	older	old	JJR
cord-356188-rwf78stz	26	20	individuals	individual	NNS
cord-356188-rwf78stz	26	21	(	(	-LRB-
cord-356188-rwf78stz	26	22	Ͼ60	Ͼ60	NNP
cord-356188-rwf78stz	26	23	years	year	NNS
cord-356188-rwf78stz	26	24	)	)	-RRB-
cord-356188-rwf78stz	26	25	,	,	,
cord-356188-rwf78stz	26	26	whereas	whereas	IN
cord-356188-rwf78stz	26	27	79	79	CD
cord-356188-rwf78stz	26	28	%	%	NN
cord-356188-rwf78stz	26	29	were	be	VBD
cord-356188-rwf78stz	26	30	Ͻ30	Ͻ30	NNP
cord-356188-rwf78stz	26	31	years	year	NNS
cord-356188-rwf78stz	26	32	old	old	JJ
cord-356188-rwf78stz	26	33	.	.	.
cord-356188-rwf78stz	27	1	Risk	risk	NN
cord-356188-rwf78stz	27	2	factors	factor	NNS
cord-356188-rwf78stz	27	3	for	for	IN
cord-356188-rwf78stz	27	4	severe	severe	JJ
cord-356188-rwf78stz	27	5	A(H1N1)pdm09	A(H1N1)pdm09	NNP
cord-356188-rwf78stz	27	6	infection	infection	NN
cord-356188-rwf78stz	27	7	are	be	VBP
cord-356188-rwf78stz	27	8	similar	similar	JJ
cord-356188-rwf78stz	27	9	to	to	IN
cord-356188-rwf78stz	27	10	those	those	DT
cord-356188-rwf78stz	27	11	for	for	IN
cord-356188-rwf78stz	27	12	seasonal	seasonal	JJ
cord-356188-rwf78stz	27	13	influenza	influenza	NN
cord-356188-rwf78stz	27	14	but	but	CC
cord-356188-rwf78stz	27	15	also	also	RB
cord-356188-rwf78stz	27	16	include	include	VBP
cord-356188-rwf78stz	27	17	obesity	obesity	NN
cord-356188-rwf78stz	27	18	.	.	.
cord-356188-rwf78stz	28	1	The	the	DT
cord-356188-rwf78stz	28	2	majority	majority	NN
cord-356188-rwf78stz	28	3	of	of	IN
cord-356188-rwf78stz	28	4	the	the	DT
cord-356188-rwf78stz	28	5	severe	severe	JJ
cord-356188-rwf78stz	28	6	or	or	CC
cord-356188-rwf78stz	28	7	fatal	fatal	JJ
cord-356188-rwf78stz	28	8	cases	case	NNS
cord-356188-rwf78stz	28	9	have	have	VBP
cord-356188-rwf78stz	28	10	accompanying	accompany	VBG
cord-356188-rwf78stz	28	11	chronic	chronic	JJ
cord-356188-rwf78stz	28	12	illnesses	illness	NNS
cord-356188-rwf78stz	28	13	,	,	,
cord-356188-rwf78stz	28	14	such	such	JJ
cord-356188-rwf78stz	28	15	as	as	IN
cord-356188-rwf78stz	28	16	cardiac	cardiac	JJ
cord-356188-rwf78stz	28	17	disease	disease	NN
cord-356188-rwf78stz	28	18	,	,	,
cord-356188-rwf78stz	28	19	chronic	chronic	JJ
cord-356188-rwf78stz	28	20	respiratory	respiratory	JJ
cord-356188-rwf78stz	28	21	diseases	disease	NNS
cord-356188-rwf78stz	28	22	,	,	,
cord-356188-rwf78stz	28	23	and	and	CC
cord-356188-rwf78stz	28	24	diabetes	diabetes	NN
cord-356188-rwf78stz	28	25	[	[	-LRB-
cord-356188-rwf78stz	28	26	25	25	CD
cord-356188-rwf78stz	28	27	]	]	-RRB-
cord-356188-rwf78stz	28	28	.	.	.
cord-356188-rwf78stz	29	1	Several	several	JJ
cord-356188-rwf78stz	29	2	studies	study	NNS
cord-356188-rwf78stz	29	3	suggest	suggest	VBP
cord-356188-rwf78stz	29	4	that	that	IN
cord-356188-rwf78stz	29	5	pregnant	pregnant	JJ
cord-356188-rwf78stz	29	6	and	and	CC
cord-356188-rwf78stz	29	7	postpartum	postpartum	NN
cord-356188-rwf78stz	29	8	women	woman	NNS
cord-356188-rwf78stz	29	9	are	be	VBP
cord-356188-rwf78stz	29	10	at	at	IN
cord-356188-rwf78stz	29	11	increased	increase	VBN
cord-356188-rwf78stz	29	12	risk	risk	NN
cord-356188-rwf78stz	29	13	for	for	IN
cord-356188-rwf78stz	29	14	complications	complication	NNS
cord-356188-rwf78stz	29	15	from	from	IN
cord-356188-rwf78stz	29	16	infections	infection	NNS
cord-356188-rwf78stz	29	17	with	with	IN
cord-356188-rwf78stz	29	18	A(H1N1)pdm09	a(h1n1)pdm09	NN
cord-356188-rwf78stz	29	19	[	[	-LRB-
cord-356188-rwf78stz	29	20	26	26	CD
cord-356188-rwf78stz	29	21	-28	-28	NN
cord-356188-rwf78stz	29	22	]	]	-RRB-
cord-356188-rwf78stz	29	23	.	.	.
cord-356188-rwf78stz	30	1	Furthermore	furthermore	RB
cord-356188-rwf78stz	30	2	,	,	,
cord-356188-rwf78stz	30	3	severity	severity	NN
cord-356188-rwf78stz	30	4	of	of	IN
cord-356188-rwf78stz	30	5	A(H1N1)pdm09	A(H1N1)pdm09	NNP
cord-356188-rwf78stz	30	6	infection	infection	NN
cord-356188-rwf78stz	30	7	was	be	VBD
cord-356188-rwf78stz	30	8	related	relate	VBN
cord-356188-rwf78stz	30	9	to	to	IN
cord-356188-rwf78stz	30	10	the	the	DT
cord-356188-rwf78stz	30	11	length	length	NN
cord-356188-rwf78stz	30	12	of	of	IN
cord-356188-rwf78stz	30	13	time	time	NN
cord-356188-rwf78stz	30	14	between	between	IN
cord-356188-rwf78stz	30	15	symptom	symptom	NN
cord-356188-rwf78stz	30	16	onset	onset	NN
cord-356188-rwf78stz	30	17	and	and	CC
cord-356188-rwf78stz	30	18	the	the	DT
cord-356188-rwf78stz	30	19	initiation	initiation	NN
cord-356188-rwf78stz	30	20	of	of	IN
cord-356188-rwf78stz	30	21	antiviral	antiviral	JJ
cord-356188-rwf78stz	30	22	treatment	treatment	NN
cord-356188-rwf78stz	30	23	with	with	IN
cord-356188-rwf78stz	30	24	NA	NA	NNP
cord-356188-rwf78stz	30	25	inhibitors	inhibitor	NNS
cord-356188-rwf78stz	30	26	[	[	-LRB-
cord-356188-rwf78stz	30	27	29	29	CD
cord-356188-rwf78stz	30	28	]	]	-RRB-
cord-356188-rwf78stz	30	29	.	.	.
cord-356188-rwf78stz	31	1	Influenza	influenza	NN
cord-356188-rwf78stz	31	2	infections	infection	NNS
cord-356188-rwf78stz	31	3	are	be	VBP
cord-356188-rwf78stz	31	4	associated	associate	VBN
cord-356188-rwf78stz	31	5	with	with	IN
cord-356188-rwf78stz	31	6	secondary	secondary	JJ
cord-356188-rwf78stz	31	7	bacterial	bacterial	JJ
cord-356188-rwf78stz	31	8	infections	infection	NNS
cord-356188-rwf78stz	31	9	,	,	,
cord-356188-rwf78stz	31	10	or	or	CC
cord-356188-rwf78stz	31	11	superinfections	superinfection	NNS
cord-356188-rwf78stz	31	12	,	,	,
cord-356188-rwf78stz	31	13	most	most	RBS
cord-356188-rwf78stz	31	14	notably	notably	RB
cord-356188-rwf78stz	31	15	,	,	,
cord-356188-rwf78stz	31	16	Streptococcus	streptococcus	NN
cord-356188-rwf78stz	31	17	pneumoniae	pneumoniae	NN
cord-356188-rwf78stz	31	18	and	and	CC
cord-356188-rwf78stz	31	19	Staphylococcus	Staphylococcus	NNP
cord-356188-rwf78stz	31	20	aureus	aureus	NN
cord-356188-rwf78stz	31	21	(	(	-LRB-
cord-356188-rwf78stz	31	22	reviewed	review	VBN
cord-356188-rwf78stz	31	23	in	in	IN
cord-356188-rwf78stz	31	24	ref	ref	NN
cord-356188-rwf78stz	31	25	.	.	.
cord-356188-rwf78stz	32	1	[	[	-LRB-
cord-356188-rwf78stz	32	2	30	30	CD
cord-356188-rwf78stz	32	3	]	]	-RRB-
cord-356188-rwf78stz	32	4	)	)	-RRB-
cord-356188-rwf78stz	32	5	.	.	.
cord-356188-rwf78stz	33	1	In	in	IN
cord-356188-rwf78stz	33	2	children	child	NNS
cord-356188-rwf78stz	33	3	,	,	,
cord-356188-rwf78stz	33	4	the	the	DT
cord-356188-rwf78stz	33	5	most	most	RBS
cord-356188-rwf78stz	33	6	common	common	JJ
cord-356188-rwf78stz	33	7	secondary	secondary	JJ
cord-356188-rwf78stz	33	8	bacterial	bacterial	JJ
cord-356188-rwf78stz	33	9	infections	infection	NNS
cord-356188-rwf78stz	33	10	lead	lead	VBP
cord-356188-rwf78stz	33	11	to	to	IN
cord-356188-rwf78stz	33	12	acute	acute	JJ
cord-356188-rwf78stz	33	13	otitis	otitis	NN
cord-356188-rwf78stz	33	14	media	medium	NNS
cord-356188-rwf78stz	33	15	,	,	,
cord-356188-rwf78stz	33	16	which	which	WDT
cord-356188-rwf78stz	33	17	is	be	VBZ
cord-356188-rwf78stz	33	18	found	find	VBN
cord-356188-rwf78stz	33	19	in	in	IN
cord-356188-rwf78stz	33	20	50	50	CD
cord-356188-rwf78stz	33	21	%	%	NN
cord-356188-rwf78stz	33	22	of	of	IN
cord-356188-rwf78stz	33	23	patients	patient	NNS
cord-356188-rwf78stz	33	24	with	with	IN
cord-356188-rwf78stz	33	25	symptomatic	symptomatic	JJ
cord-356188-rwf78stz	33	26	influenza	influenza	NN
cord-356188-rwf78stz	33	27	infection	infection	NN
cord-356188-rwf78stz	33	28	,	,	,
cord-356188-rwf78stz	33	29	with	with	IN
cord-356188-rwf78stz	33	30	five	five	CD
cord-356188-rwf78stz	33	31	to	to	TO
cord-356188-rwf78stz	33	32	six	six	CD
cord-356188-rwf78stz	33	33	cases	case	NNS
cord-356188-rwf78stz	33	34	observed	observe	VBN
cord-356188-rwf78stz	33	35	annually	annually	RB
cord-356188-rwf78stz	33	36	for	for	IN
cord-356188-rwf78stz	33	37	every	every	DT
cord-356188-rwf78stz	33	38	100	100	CD
cord-356188-rwf78stz	33	39	children	child	NNS
cord-356188-rwf78stz	33	40	Ͻ2	ͻ2	CD
cord-356188-rwf78stz	33	41	years	year	NNS
cord-356188-rwf78stz	33	42	of	of	IN
cord-356188-rwf78stz	33	43	age	age	NN
cord-356188-rwf78stz	33	44	[	[	-LRB-
cord-356188-rwf78stz	33	45	10	10	CD
cord-356188-rwf78stz	33	46	]	]	-RRB-
cord-356188-rwf78stz	33	47	.	.	.
cord-356188-rwf78stz	34	1	Since	since	IN
cord-356188-rwf78stz	34	2	the	the	DT
cord-356188-rwf78stz	34	3	emergence	emergence	NN
cord-356188-rwf78stz	34	4	of	of	IN
cord-356188-rwf78stz	34	5	A(H1N1)pdm09	A(H1N1)pdm09	NNP
cord-356188-rwf78stz	34	6	,	,	,
cord-356188-rwf78stz	34	7	approximately	approximately	RB
cord-356188-rwf78stz	34	8	one	one	CD
cord-356188-rwf78stz	34	9	-	-	HYPH
cord-356188-rwf78stz	34	10	third	third	NN
cord-356188-rwf78stz	34	11	of	of	IN
cord-356188-rwf78stz	34	12	fatal	fatal	JJ
cord-356188-rwf78stz	34	13	infections	infection	NNS
cord-356188-rwf78stz	34	14	are	be	VBP
cord-356188-rwf78stz	34	15	associated	associate	VBN
cord-356188-rwf78stz	34	16	with	with	IN
cord-356188-rwf78stz	34	17	bacterial	bacterial	JJ
cord-356188-rwf78stz	34	18	coinfection	coinfection	NN
cord-356188-rwf78stz	34	19	[	[	-LRB-
cord-356188-rwf78stz	34	20	31	31	CD
cord-356188-rwf78stz	34	21	,	,	,
cord-356188-rwf78stz	34	22	32	32	CD
cord-356188-rwf78stz	34	23	]	]	-RRB-
cord-356188-rwf78stz	34	24	,	,	,
cord-356188-rwf78stz	34	25	but	but	CC
cord-356188-rwf78stz	34	26	this	this	DT
cord-356188-rwf78stz	34	27	number	number	NN
cord-356188-rwf78stz	34	28	includes	include	VBZ
cord-356188-rwf78stz	34	29	cases	case	NNS
cord-356188-rwf78stz	34	30	where	where	WRB
cord-356188-rwf78stz	34	31	respiratory	respiratory	JJ
cord-356188-rwf78stz	34	32	support	support	NN
cord-356188-rwf78stz	34	33	is	be	VBZ
cord-356188-rwf78stz	34	34	needed	need	VBN
cord-356188-rwf78stz	34	35	,	,	,
cord-356188-rwf78stz	34	36	adding	add	VBG
cord-356188-rwf78stz	34	37	to	to	IN
cord-356188-rwf78stz	34	38	the	the	DT
cord-356188-rwf78stz	34	39	risk	risk	NN
cord-356188-rwf78stz	34	40	of	of	IN
cord-356188-rwf78stz	34	41	secondary	secondary	JJ
cord-356188-rwf78stz	34	42	infections	infection	NNS
cord-356188-rwf78stz	34	43	.	.	.
cord-356188-rwf78stz	35	1	In	in	IN
cord-356188-rwf78stz	35	2	fatal	fatal	JJ
cord-356188-rwf78stz	35	3	cases	case	NNS
cord-356188-rwf78stz	35	4	of	of	IN
cord-356188-rwf78stz	35	5	those	those	DT
cord-356188-rwf78stz	35	6	infected	infect	VBN
cord-356188-rwf78stz	35	7	by	by	IN
cord-356188-rwf78stz	35	8	A(H1N1)pdm09	A(H1N1)pdm09	NNP
cord-356188-rwf78stz	35	9	,	,	,
cord-356188-rwf78stz	35	10	diffuse	diffuse	VB
cord-356188-rwf78stz	35	11	alveolar	alveolar	NN
cord-356188-rwf78stz	35	12	damage	damage	NN
cord-356188-rwf78stz	35	13	alone	alone	RB
cord-356188-rwf78stz	35	14	,	,	,
cord-356188-rwf78stz	35	15	diffuse	diffuse	VB
cord-356188-rwf78stz	35	16	alveolar	alveolar	JJ
cord-356188-rwf78stz	35	17	damage	damage	NN
cord-356188-rwf78stz	35	18	associated	associate	VBN
cord-356188-rwf78stz	35	19	with	with	IN
cord-356188-rwf78stz	35	20	necrotizing	necrotize	VBG
cord-356188-rwf78stz	35	21	bronchiolitis	bronchiolitis	NN
cord-356188-rwf78stz	35	22	,	,	,
cord-356188-rwf78stz	35	23	and	and	CC
cord-356188-rwf78stz	35	24	diffuse	diffuse	VB
cord-356188-rwf78stz	35	25	alveolar	alveolar	JJ
cord-356188-rwf78stz	35	26	damage	damage	NN
cord-356188-rwf78stz	35	27	with	with	IN
cord-356188-rwf78stz	35	28	hemorrhage	hemorrhage	NN
cord-356188-rwf78stz	35	29	were	be	VBD
cord-356188-rwf78stz	35	30	found	find	VBN
cord-356188-rwf78stz	35	31	,	,	,
cord-356188-rwf78stz	35	32	and	and	CC
cord-356188-rwf78stz	35	33	in	in	IN
cord-356188-rwf78stz	35	34	most	most	JJS
cord-356188-rwf78stz	35	35	of	of	IN
cord-356188-rwf78stz	35	36	the	the	DT
cord-356188-rwf78stz	35	37	cases	case	NNS
cord-356188-rwf78stz	35	38	where	where	WRB
cord-356188-rwf78stz	35	39	necrotizing	necrotize	VBG
cord-356188-rwf78stz	35	40	bronchiolitis	bronchiolitis	NN
cord-356188-rwf78stz	35	41	was	be	VBD
cord-356188-rwf78stz	35	42	found	find	VBN
cord-356188-rwf78stz	35	43	,	,	,
cord-356188-rwf78stz	35	44	the	the	DT
cord-356188-rwf78stz	35	45	individuals	individual	NNS
cord-356188-rwf78stz	35	46	had	have	VBD
cord-356188-rwf78stz	35	47	bacterial	bacterial	JJ
cord-356188-rwf78stz	35	48	coinfections	coinfection	NNS
cord-356188-rwf78stz	35	49	[	[	-LRB-
cord-356188-rwf78stz	35	50	33	33	CD
cord-356188-rwf78stz	35	51	]	]	-RRB-
cord-356188-rwf78stz	35	52	.	.	.
cord-356188-rwf78stz	36	1	Vaccination	vaccination	NN
cord-356188-rwf78stz	36	2	remains	remain	VBZ
cord-356188-rwf78stz	36	3	an	an	DT
cord-356188-rwf78stz	36	4	effective	effective	JJ
cord-356188-rwf78stz	36	5	and	and	CC
cord-356188-rwf78stz	36	6	primary	primary	JJ
cord-356188-rwf78stz	36	7	preventive	preventive	JJ
cord-356188-rwf78stz	36	8	strategy	strategy	NN
cord-356188-rwf78stz	36	9	to	to	TO
cord-356188-rwf78stz	36	10	avert	avert	VB
cord-356188-rwf78stz	36	11	influenza	influenza	NN
cord-356188-rwf78stz	36	12	infection	infection	NN
cord-356188-rwf78stz	36	13	.	.	.
cord-356188-rwf78stz	37	1	The	the	DT
cord-356188-rwf78stz	37	2	World	World	NNP
cord-356188-rwf78stz	37	3	Health	Health	NNP
cord-356188-rwf78stz	37	4	Organization	Organization	NNP
cord-356188-rwf78stz	37	5	and	and	CC
cord-356188-rwf78stz	37	6	CDC	CDC	NNP
cord-356188-rwf78stz	37	7	recommend	recommend	VBP
cord-356188-rwf78stz	37	8	that	that	IN
cord-356188-rwf78stz	37	9	children	child	NNS
cord-356188-rwf78stz	37	10	and	and	CC
cord-356188-rwf78stz	37	11	adults	adult	NNS
cord-356188-rwf78stz	37	12	over	over	IN
cord-356188-rwf78stz	37	13	the	the	DT
cord-356188-rwf78stz	37	14	age	age	NN
cord-356188-rwf78stz	37	15	of	of	IN
cord-356188-rwf78stz	37	16	6	6	CD
cord-356188-rwf78stz	37	17	months	month	NNS
cord-356188-rwf78stz	37	18	receive	receive	VBP
cord-356188-rwf78stz	37	19	an	an	DT
cord-356188-rwf78stz	37	20	influenza	influenza	NN
cord-356188-rwf78stz	37	21	vaccination	vaccination	NN
cord-356188-rwf78stz	37	22	annually	annually	RB
cord-356188-rwf78stz	37	23	[	[	-LRB-
cord-356188-rwf78stz	37	24	34	34	CD
cord-356188-rwf78stz	37	25	]	]	-RRB-
cord-356188-rwf78stz	37	26	.	.	.
cord-356188-rwf78stz	38	1	Currently	currently	RB
cord-356188-rwf78stz	38	2	,	,	,
cord-356188-rwf78stz	38	3	there	there	EX
cord-356188-rwf78stz	38	4	are	be	VBP
cord-356188-rwf78stz	38	5	three	three	CD
cord-356188-rwf78stz	38	6	licensed	license	VBN
cord-356188-rwf78stz	38	7	seasonal	seasonal	JJ
cord-356188-rwf78stz	38	8	vaccines	vaccine	NNS
cord-356188-rwf78stz	38	9	administered	administer	VBN
cord-356188-rwf78stz	38	10	in	in	IN
cord-356188-rwf78stz	38	11	the	the	DT
cord-356188-rwf78stz	38	12	United	United	NNP
cord-356188-rwf78stz	38	13	States	States	NNP
cord-356188-rwf78stz	38	14	:	:	:
cord-356188-rwf78stz	38	15	1	1	LS
cord-356188-rwf78stz	38	16	)	)	-RRB-
cord-356188-rwf78stz	38	17	a	a	DT
cord-356188-rwf78stz	38	18	TIV	TIV	NNP
cord-356188-rwf78stz	38	19	,	,	,
cord-356188-rwf78stz	38	20	administered	administer	VBN
cord-356188-rwf78stz	38	21	by	by	IN
cord-356188-rwf78stz	38	22	i.m	i.m	NNP
cord-356188-rwf78stz	38	23	.	.	NNP
cord-356188-rwf78stz	38	24	injection	injection	NN
cord-356188-rwf78stz	38	25	;	;	:
cord-356188-rwf78stz	38	26	2	2	LS
cord-356188-rwf78stz	38	27	)	)	-RRB-
cord-356188-rwf78stz	38	28	a	a	DT
cord-356188-rwf78stz	38	29	LAIV	LAIV	NNP
cord-356188-rwf78stz	38	30	,	,	,
cord-356188-rwf78stz	38	31	delivered	deliver	VBN
cord-356188-rwf78stz	38	32	intranasally	intranasally	RB
cord-356188-rwf78stz	38	33	;	;	:
cord-356188-rwf78stz	38	34	and	and	CC
cord-356188-rwf78stz	38	35	3	3	LS
cord-356188-rwf78stz	38	36	)	)	-RRB-
cord-356188-rwf78stz	38	37	an	an	DT
cord-356188-rwf78stz	38	38	i.d.-administered	i.d.-administered	JJ
cord-356188-rwf78stz	38	39	TIV	TIV	NNP
cord-356188-rwf78stz	38	40	preparation	preparation	NN
cord-356188-rwf78stz	38	41	[	[	-LRB-
cord-356188-rwf78stz	38	42	35	35	CD
cord-356188-rwf78stz	38	43	]	]	-RRB-
cord-356188-rwf78stz	38	44	.	.	.
cord-356188-rwf78stz	39	1	Each	each	DT
cord-356188-rwf78stz	39	2	includes	include	VBZ
cord-356188-rwf78stz	39	3	three	three	CD
cord-356188-rwf78stz	39	4	circulating	circulate	VBG
cord-356188-rwf78stz	39	5	strains	strain	NNS
cord-356188-rwf78stz	39	6	of	of	IN
cord-356188-rwf78stz	39	7	influenza	influenza	NN
cord-356188-rwf78stz	39	8	grown	grow	VBN
cord-356188-rwf78stz	39	9	in	in	IN
cord-356188-rwf78stz	39	10	eggs	egg	NNS
cord-356188-rwf78stz	39	11	,	,	,
cord-356188-rwf78stz	39	12	reflecting	reflect	VBG
cord-356188-rwf78stz	39	13	annual	annual	JJ
cord-356188-rwf78stz	39	14	surveillance	surveillance	NN
cord-356188-rwf78stz	39	15	data	datum	NNS
cord-356188-rwf78stz	39	16	that	that	WDT
cord-356188-rwf78stz	39	17	predict	predict	VBP
cord-356188-rwf78stz	39	18	which	which	WDT
cord-356188-rwf78stz	39	19	strains	strain	NNS
cord-356188-rwf78stz	39	20	(	(	-LRB-
cord-356188-rwf78stz	39	21	A	A	NNP
cord-356188-rwf78stz	39	22	/	/	SYM
cord-356188-rwf78stz	39	23	H1	H1	NNP
cord-356188-rwf78stz	39	24	,	,	,
cord-356188-rwf78stz	39	25	A	A	NNP
cord-356188-rwf78stz	39	26	/	/	SYM
cord-356188-rwf78stz	39	27	H3	H3	NNP
cord-356188-rwf78stz	39	28	,	,	,
cord-356188-rwf78stz	39	29	and	and	CC
cord-356188-rwf78stz	39	30	B	B	NNP
cord-356188-rwf78stz	39	31	)	)	-RRB-
cord-356188-rwf78stz	39	32	are	be	VBP
cord-356188-rwf78stz	39	33	most	most	RBS
cord-356188-rwf78stz	39	34	likely	likely	JJ
cord-356188-rwf78stz	39	35	to	to	TO
cord-356188-rwf78stz	39	36	be	be	VB
cord-356188-rwf78stz	39	37	circulating	circulate	VBG
cord-356188-rwf78stz	39	38	the	the	DT
cord-356188-rwf78stz	39	39	following	follow	VBG
cord-356188-rwf78stz	39	40	season	season	NN
cord-356188-rwf78stz	39	41	in	in	IN
cord-356188-rwf78stz	39	42	northern	northern	JJ
cord-356188-rwf78stz	39	43	and	and	CC
cord-356188-rwf78stz	39	44	southern	southern	JJ
cord-356188-rwf78stz	39	45	hemispheres	hemisphere	NNS
cord-356188-rwf78stz	39	46	.	.	.
cord-356188-rwf78stz	40	1	The	the	DT
cord-356188-rwf78stz	40	2	i.m	i.m	NNP
cord-356188-rwf78stz	40	3	.	.	.
cord-356188-rwf78stz	40	4	TIV	TIV	NNP
cord-356188-rwf78stz	40	5	is	be	VBZ
cord-356188-rwf78stz	40	6	approved	approve	VBN
cord-356188-rwf78stz	40	7	for	for	IN
cord-356188-rwf78stz	40	8	use	use	NN
cord-356188-rwf78stz	40	9	in	in	IN
cord-356188-rwf78stz	40	10	children	child	NNS
cord-356188-rwf78stz	40	11	and	and	CC
cord-356188-rwf78stz	40	12	adults	adult	NNS
cord-356188-rwf78stz	40	13	over	over	IN
cord-356188-rwf78stz	40	14	6	6	CD
cord-356188-rwf78stz	40	15	months	month	NNS
cord-356188-rwf78stz	40	16	of	of	IN
cord-356188-rwf78stz	40	17	age	age	NN
cord-356188-rwf78stz	40	18	,	,	,
cord-356188-rwf78stz	40	19	whereas	whereas	IN
cord-356188-rwf78stz	40	20	the	the	DT
cord-356188-rwf78stz	40	21	newer	new	JJR
cord-356188-rwf78stz	40	22	i.d	i.d	NNP
cord-356188-rwf78stz	40	23	.	.	NNP
cord-356188-rwf78stz	40	24	TIV	TIV	NNP
cord-356188-rwf78stz	40	25	is	be	VBZ
cord-356188-rwf78stz	40	26	approved	approve	VBN
cord-356188-rwf78stz	40	27	for	for	IN
cord-356188-rwf78stz	40	28	adults	adult	NNS
cord-356188-rwf78stz	40	29	aged	age	VBN
cord-356188-rwf78stz	40	30	18	18	CD
cord-356188-rwf78stz	40	31	-64	-64	NNS
cord-356188-rwf78stz	40	32	years	year	NNS
cord-356188-rwf78stz	40	33	.	.	.
cord-356188-rwf78stz	41	1	LAIV	LAIV	NNP
cord-356188-rwf78stz	41	2	is	be	VBZ
cord-356188-rwf78stz	41	3	approved	approve	VBN
cord-356188-rwf78stz	41	4	for	for	IN
cord-356188-rwf78stz	41	5	use	use	NN
cord-356188-rwf78stz	41	6	in	in	IN
cord-356188-rwf78stz	41	7	healthy	healthy	JJ
cord-356188-rwf78stz	41	8	children	child	NNS
cord-356188-rwf78stz	41	9	and	and	CC
cord-356188-rwf78stz	41	10	adults	adult	NNS
cord-356188-rwf78stz	41	11	between	between	IN
cord-356188-rwf78stz	41	12	2	2	CD
cord-356188-rwf78stz	41	13	and	and	CC
cord-356188-rwf78stz	41	14	49	49	CD
cord-356188-rwf78stz	41	15	years	year	NNS
cord-356188-rwf78stz	41	16	of	of	IN
cord-356188-rwf78stz	41	17	age	age	NN
cord-356188-rwf78stz	41	18	.	.	.
cord-356188-rwf78stz	42	1	The	the	DT
cord-356188-rwf78stz	42	2	current	current	JJ
cord-356188-rwf78stz	42	3	influenza	influenza	NN
cord-356188-rwf78stz	42	4	vaccines	vaccine	NNS
cord-356188-rwf78stz	42	5	work	work	VBP
cord-356188-rwf78stz	42	6	to	to	TO
cord-356188-rwf78stz	42	7	induce	induce	VB
cord-356188-rwf78stz	42	8	memory	memory	NN
cord-356188-rwf78stz	42	9	recall	recall	NN
cord-356188-rwf78stz	42	10	responses	response	NNS
cord-356188-rwf78stz	42	11	,	,	,
cord-356188-rwf78stz	42	12	primarily	primarily	RB
cord-356188-rwf78stz	42	13	via	via	IN
cord-356188-rwf78stz	42	14	humoral	humoral	JJ
cord-356188-rwf78stz	42	15	immune	immune	JJ
cord-356188-rwf78stz	42	16	responses	response	NNS
cord-356188-rwf78stz	42	17	against	against	IN
cord-356188-rwf78stz	42	18	the	the	DT
cord-356188-rwf78stz	42	19	HA	HA	NNP
cord-356188-rwf78stz	42	20	and	and	CC
cord-356188-rwf78stz	42	21	NA	NA	NNP
cord-356188-rwf78stz	42	22	surface	surface	NN
cord-356188-rwf78stz	42	23	glycoproteins	glycoprotein	NNS
cord-356188-rwf78stz	42	24	,	,	,
cord-356188-rwf78stz	42	25	and	and	CC
cord-356188-rwf78stz	42	26	HA	HA	NNP
cord-356188-rwf78stz	42	27	inhibition	inhibition	NN
cord-356188-rwf78stz	42	28	antibody	antibody	NN
cord-356188-rwf78stz	42	29	responses	response	NNS
cord-356188-rwf78stz	42	30	following	follow	VBG
cord-356188-rwf78stz	42	31	immunization	immunization	NN
cord-356188-rwf78stz	42	32	correlates	correlate	VBZ
cord-356188-rwf78stz	42	33	with	with	IN
cord-356188-rwf78stz	42	34	protection	protection	NN
cord-356188-rwf78stz	42	35	against	against	IN
cord-356188-rwf78stz	42	36	infection	infection	NN
cord-356188-rwf78stz	42	37	[	[	-LRB-
cord-356188-rwf78stz	42	38	36	36	CD
cord-356188-rwf78stz	42	39	,	,	,
cord-356188-rwf78stz	42	40	37	37	CD
cord-356188-rwf78stz	42	41	]	]	-RRB-
cord-356188-rwf78stz	42	42	.	.	.
cord-356188-rwf78stz	43	1	The	the	DT
cord-356188-rwf78stz	43	2	main	main	JJ
cord-356188-rwf78stz	43	3	component	component	NN
cord-356188-rwf78stz	43	4	standardized	standardize	VBN
cord-356188-rwf78stz	43	5	in	in	IN
cord-356188-rwf78stz	43	6	influenza	influenza	NN
cord-356188-rwf78stz	43	7	vaccines	vaccine	NNS
cord-356188-rwf78stz	43	8	is	be	VBZ
cord-356188-rwf78stz	43	9	the	the	DT
cord-356188-rwf78stz	43	10	HA	HA	NNP
cord-356188-rwf78stz	43	11	protein	protein	NN
cord-356188-rwf78stz	43	12	,	,	,
cord-356188-rwf78stz	43	13	and	and	CC
cord-356188-rwf78stz	43	14	it	-PRON-	PRP
cord-356188-rwf78stz	43	15	is	be	VBZ
cord-356188-rwf78stz	43	16	well	well	RB
cord-356188-rwf78stz	43	17	-	-	HYPH
cord-356188-rwf78stz	43	18	characterized	characterize	VBN
cord-356188-rwf78stz	43	19	in	in	IN
cord-356188-rwf78stz	43	20	safety	safety	NN
cord-356188-rwf78stz	43	21	trials	trial	NNS
cord-356188-rwf78stz	43	22	and	and	CC
cord-356188-rwf78stz	43	23	challenge	challenge	NN
cord-356188-rwf78stz	43	24	studies	study	NNS
cord-356188-rwf78stz	43	25	that	that	IN
cord-356188-rwf78stz	43	26	the	the	DT
cord-356188-rwf78stz	43	27	amount	amount	NN
cord-356188-rwf78stz	43	28	of	of	IN
cord-356188-rwf78stz	43	29	HA	HA	NNP
cord-356188-rwf78stz	43	30	within	within	IN
cord-356188-rwf78stz	43	31	the	the	DT
cord-356188-rwf78stz	43	32	vaccine	vaccine	NN
cord-356188-rwf78stz	43	33	correlates	correlate	VBZ
cord-356188-rwf78stz	43	34	with	with	IN
cord-356188-rwf78stz	43	35	level	level	NN
cord-356188-rwf78stz	43	36	of	of	IN
cord-356188-rwf78stz	43	37	protection	protection	NN
cord-356188-rwf78stz	43	38	elicited	elicit	VBN
cord-356188-rwf78stz	43	39	by	by	IN
cord-356188-rwf78stz	43	40	immunization	immunization	NN
cord-356188-rwf78stz	43	41	[	[	-LRB-
cord-356188-rwf78stz	43	42	38	38	CD
cord-356188-rwf78stz	43	43	,	,	,
cord-356188-rwf78stz	43	44	39	39	CD
cord-356188-rwf78stz	43	45	]	]	-RRB-
cord-356188-rwf78stz	43	46	.	.	.
cord-356188-rwf78stz	44	1	Beginning	begin	VBG
cord-356188-rwf78stz	44	2	during	during	IN
cord-356188-rwf78stz	44	3	the	the	DT
cord-356188-rwf78stz	44	4	northern	northern	JJ
cord-356188-rwf78stz	44	5	hemisphere	hemisphere	NN
cord-356188-rwf78stz	44	6	's	's	POS
cord-356188-rwf78stz	44	7	2010	2010	CD
cord-356188-rwf78stz	44	8	-2011	-2011	NN
cord-356188-rwf78stz	44	9	influenza	influenza	NN
cord-356188-rwf78stz	44	10	season	season	NN
cord-356188-rwf78stz	44	11	,	,	,
cord-356188-rwf78stz	44	12	a	a	DT
cord-356188-rwf78stz	44	13	vaccine	vaccine	NN
cord-356188-rwf78stz	44	14	containing	contain	VBG
cord-356188-rwf78stz	44	15	60	60	CD
cord-356188-rwf78stz	44	16	g	g	NN
cord-356188-rwf78stz	44	17	HA	HA	NNP
cord-356188-rwf78stz	44	18	/	/	SYM
cord-356188-rwf78stz	44	19	vaccine	vaccine	NN
cord-356188-rwf78stz	44	20	strain	strain	NN
cord-356188-rwf78stz	44	21	,	,	,
cord-356188-rwf78stz	44	22	as	as	IN
cord-356188-rwf78stz	44	23	opposed	oppose	VBN
cord-356188-rwf78stz	44	24	to	to	IN
cord-356188-rwf78stz	44	25	15	15	CD
cord-356188-rwf78stz	44	26	g	g	NN
cord-356188-rwf78stz	44	27	in	in	IN
cord-356188-rwf78stz	44	28	other	other	JJ
cord-356188-rwf78stz	44	29	preparations	preparation	NNS
cord-356188-rwf78stz	44	30	,	,	,
cord-356188-rwf78stz	44	31	was	be	VBD
cord-356188-rwf78stz	44	32	approved	approve	VBN
cord-356188-rwf78stz	44	33	as	as	IN
cord-356188-rwf78stz	44	34	an	an	DT
cord-356188-rwf78stz	44	35	alternative	alternative	JJ
cord-356188-rwf78stz	44	36	TIV	TIV	NNP
cord-356188-rwf78stz	44	37	for	for	IN
cord-356188-rwf78stz	44	38	elderly	elderly	JJ
cord-356188-rwf78stz	44	39	individuals	individual	NNS
cord-356188-rwf78stz	44	40	(	(	-LRB-
cord-356188-rwf78stz	44	41	over	over	IN
cord-356188-rwf78stz	44	42	age	age	NN
cord-356188-rwf78stz	44	43	65	65	CD
cord-356188-rwf78stz	44	44	years	year	NNS
cord-356188-rwf78stz	44	45	)	)	-RRB-
cord-356188-rwf78stz	45	1	[	[	-LRB-
cord-356188-rwf78stz	45	2	35	35	CD
cord-356188-rwf78stz	45	3	]	]	-RRB-
cord-356188-rwf78stz	45	4	.	.	.
cord-356188-rwf78stz	46	1	Following	follow	VBG
cord-356188-rwf78stz	46	2	vaccination	vaccination	NN
cord-356188-rwf78stz	46	3	,	,	,
cord-356188-rwf78stz	46	4	ASCs	ASCs	NNP
cord-356188-rwf78stz	46	5	rapidly	rapidly	RB
cord-356188-rwf78stz	46	6	proliferate	proliferate	VBP
cord-356188-rwf78stz	46	7	upon	upon	IN
cord-356188-rwf78stz	46	8	antigen	antigen	NN
cord-356188-rwf78stz	46	9	exposure	exposure	NN
cord-356188-rwf78stz	46	10	,	,	,
cord-356188-rwf78stz	46	11	and	and	CC
cord-356188-rwf78stz	46	12	cell	cell	NN
cord-356188-rwf78stz	46	13	numbers	number	NNS
cord-356188-rwf78stz	46	14	peak	peak	NN
cord-356188-rwf78stz	46	15	1	1	CD
cord-356188-rwf78stz	46	16	week	week	NN
cord-356188-rwf78stz	46	17	postimmunization	postimmunization	NN
cord-356188-rwf78stz	46	18	in	in	IN
cord-356188-rwf78stz	46	19	healthy	healthy	JJ
cord-356188-rwf78stz	46	20	adults	adult	NNS
cord-356188-rwf78stz	46	21	and	and	CC
cord-356188-rwf78stz	46	22	children	child	NNS
cord-356188-rwf78stz	46	23	[	[	-LRB-
cord-356188-rwf78stz	46	24	40	40	CD
cord-356188-rwf78stz	46	25	,	,	,
cord-356188-rwf78stz	46	26	41	41	CD
cord-356188-rwf78stz	46	27	]	]	-RRB-
cord-356188-rwf78stz	46	28	.	.	.
cord-356188-rwf78stz	47	1	IgG	IgG	NNP
cord-356188-rwf78stz	47	2	and	and	CC
cord-356188-rwf78stz	47	3	IgA	IgA	NNP
cord-356188-rwf78stz	47	4	ASCs	ASCs	NNP
cord-356188-rwf78stz	47	5	decline	decline	NN
cord-356188-rwf78stz	47	6	to	to	IN
cord-356188-rwf78stz	47	7	low	low	JJ
cord-356188-rwf78stz	47	8	levels	level	NNS
cord-356188-rwf78stz	47	9	by	by	IN
cord-356188-rwf78stz	47	10	4	4	CD
cord-356188-rwf78stz	47	11	-6	-6	CD
cord-356188-rwf78stz	47	12	weeks	week	NNS
cord-356188-rwf78stz	47	13	postimmunization	postimmunization	XX
cord-356188-rwf78stz	47	14	[	[	-LRB-
cord-356188-rwf78stz	47	15	42	42	CD
cord-356188-rwf78stz	47	16	,	,	,
cord-356188-rwf78stz	47	17	43	43	CD
cord-356188-rwf78stz	47	18	]	]	-RRB-
cord-356188-rwf78stz	47	19	.	.	.
cord-356188-rwf78stz	48	1	This	this	DT
cord-356188-rwf78stz	48	2	increase	increase	NN
cord-356188-rwf78stz	48	3	in	in	IN
cord-356188-rwf78stz	48	4	the	the	DT
cord-356188-rwf78stz	48	5	total	total	JJ
cord-356188-rwf78stz	48	6	numbers	number	NNS
cord-356188-rwf78stz	48	7	of	of	IN
cord-356188-rwf78stz	48	8	ASCs	ASCs	NNP
cord-356188-rwf78stz	48	9	corre	corre	NN
cord-356188-rwf78stz	48	10	-	-	HYPH
cord-356188-rwf78stz	48	11	sponds	spond	NNS
cord-356188-rwf78stz	48	12	to	to	IN
cord-356188-rwf78stz	48	13	nAb	nAb	NNP
cord-356188-rwf78stz	48	14	levels	level	NNS
cord-356188-rwf78stz	48	15	postvaccination	postvaccination	NN
cord-356188-rwf78stz	48	16	,	,	,
cord-356188-rwf78stz	48	17	peaking	peak	VBG
cord-356188-rwf78stz	48	18	at	at	IN
cord-356188-rwf78stz	48	19	4	4	CD
cord-356188-rwf78stz	48	20	weeks	week	NNS
cord-356188-rwf78stz	48	21	in	in	IN
cord-356188-rwf78stz	48	22	adults	adult	NNS
cord-356188-rwf78stz	48	23	and	and	CC
cord-356188-rwf78stz	48	24	children	child	NNS
cord-356188-rwf78stz	48	25	[	[	-LRB-
cord-356188-rwf78stz	48	26	43	43	CD
cord-356188-rwf78stz	48	27	]	]	-RRB-
cord-356188-rwf78stz	48	28	.	.	.
cord-356188-rwf78stz	49	1	LAIV	LAIV	NNP
cord-356188-rwf78stz	49	2	elicits	elicit	VBZ
cord-356188-rwf78stz	49	3	a	a	DT
cord-356188-rwf78stz	49	4	strong	strong	JJ
cord-356188-rwf78stz	49	5	serum	serum	NN
cord-356188-rwf78stz	49	6	and	and	CC
cord-356188-rwf78stz	49	7	mucosal	mucosal	JJ
cord-356188-rwf78stz	49	8	influenza	influenza	NN
cord-356188-rwf78stz	49	9	-	-	HYPH
cord-356188-rwf78stz	49	10	specific	specific	JJ
cord-356188-rwf78stz	49	11	antibody	antibody	NN
cord-356188-rwf78stz	49	12	response	response	NN
cord-356188-rwf78stz	49	13	[	[	-LRB-
cord-356188-rwf78stz	49	14	44	44	CD
cord-356188-rwf78stz	49	15	]	]	-RRB-
cord-356188-rwf78stz	49	16	,	,	,
cord-356188-rwf78stz	49	17	and	and	CC
cord-356188-rwf78stz	49	18	studies	study	NNS
cord-356188-rwf78stz	49	19	in	in	IN
cord-356188-rwf78stz	49	20	young	young	JJ
cord-356188-rwf78stz	49	21	children	child	NNS
cord-356188-rwf78stz	49	22	(	(	-LRB-
cord-356188-rwf78stz	49	23	6	6	CD
cord-356188-rwf78stz	49	24	-59	-59	NN
cord-356188-rwf78stz	49	25	months	month	NNS
cord-356188-rwf78stz	49	26	of	of	IN
cord-356188-rwf78stz	49	27	age	age	NN
cord-356188-rwf78stz	49	28	)	)	-RRB-
cord-356188-rwf78stz	49	29	showed	show	VBD
cord-356188-rwf78stz	49	30	that	that	IN
cord-356188-rwf78stz	49	31	those	those	DT
cord-356188-rwf78stz	49	32	receiving	receive	VBG
cord-356188-rwf78stz	49	33	LAIV	LAIV	NNP
cord-356188-rwf78stz	49	34	had	have	VBD
cord-356188-rwf78stz	49	35	significantly	significantly	RB
cord-356188-rwf78stz	49	36	reduced	reduce	VBN
cord-356188-rwf78stz	49	37	incidence	incidence	NN
cord-356188-rwf78stz	49	38	of	of	IN
cord-356188-rwf78stz	49	39	influenza	influenza	NN
cord-356188-rwf78stz	49	40	infection	infection	NN
cord-356188-rwf78stz	49	41	[	[	-LRB-
cord-356188-rwf78stz	49	42	45	45	CD
cord-356188-rwf78stz	49	43	]	]	-RRB-
cord-356188-rwf78stz	49	44	.	.	.
cord-356188-rwf78stz	50	1	Although	although	IN
cord-356188-rwf78stz	50	2	limited	limited	JJ
cord-356188-rwf78stz	50	3	data	datum	NNS
cord-356188-rwf78stz	50	4	exist	exist	VBP
cord-356188-rwf78stz	50	5	,	,	,
cord-356188-rwf78stz	50	6	influenza	influenza	NN
cord-356188-rwf78stz	50	7	-	-	HYPH
cord-356188-rwf78stz	50	8	specific	specific	JJ
cord-356188-rwf78stz	50	9	ASCs	asc	NNS
cord-356188-rwf78stz	50	10	and	and	CC
cord-356188-rwf78stz	50	11	nAb	nAb	NNP
cord-356188-rwf78stz	50	12	titers	titer	NNS
cord-356188-rwf78stz	50	13	are	be	VBP
cord-356188-rwf78stz	50	14	increased	increase	VBN
cord-356188-rwf78stz	50	15	to	to	IN
cord-356188-rwf78stz	50	16	a	a	DT
cord-356188-rwf78stz	50	17	greater	great	JJR
cord-356188-rwf78stz	50	18	degree	degree	NN
cord-356188-rwf78stz	50	19	following	follow	VBG
cord-356188-rwf78stz	50	20	TIV	TIV	NNP
cord-356188-rwf78stz	50	21	immunization	immunization	NN
cord-356188-rwf78stz	50	22	compared	compare	VBN
cord-356188-rwf78stz	50	23	with	with	IN
cord-356188-rwf78stz	50	24	LAIV	LAIV	NNP
cord-356188-rwf78stz	50	25	vaccination	vaccination	NN
cord-356188-rwf78stz	50	26	[	[	-LRB-
cord-356188-rwf78stz	50	27	43	43	CD
cord-356188-rwf78stz	50	28	,	,	,
cord-356188-rwf78stz	50	29	46	46	CD
cord-356188-rwf78stz	50	30	,	,	,
cord-356188-rwf78stz	50	31	47	47	CD
cord-356188-rwf78stz	50	32	]	]	-RRB-
cord-356188-rwf78stz	50	33	,	,	,
cord-356188-rwf78stz	50	34	but	but	CC
cord-356188-rwf78stz	50	35	the	the	DT
cord-356188-rwf78stz	50	36	role	role	NN
cord-356188-rwf78stz	50	37	of	of	IN
cord-356188-rwf78stz	50	38	neutralization	neutralization	NN
cord-356188-rwf78stz	50	39	of	of	IN
cord-356188-rwf78stz	50	40	LAIV	LAIV	NNP
cord-356188-rwf78stz	50	41	occurring	occur	VBG
cord-356188-rwf78stz	50	42	in	in	IN
cord-356188-rwf78stz	50	43	antigen	antigen	NN
cord-356188-rwf78stz	50	44	-	-	HYPH
cord-356188-rwf78stz	50	45	experienced	experience	VBN
cord-356188-rwf78stz	50	46	individuals	individual	NNS
cord-356188-rwf78stz	50	47	is	be	VBZ
cord-356188-rwf78stz	50	48	not	not	RB
cord-356188-rwf78stz	50	49	well	well	RB
cord-356188-rwf78stz	50	50	understood	understand	VBN
cord-356188-rwf78stz	50	51	.	.	.
cord-356188-rwf78stz	51	1	Influenza	influenza	NN
cord-356188-rwf78stz	51	2	immunization	immunization	NN
cord-356188-rwf78stz	51	3	is	be	VBZ
cord-356188-rwf78stz	51	4	effective	effective	JJ
cord-356188-rwf78stz	51	5	,	,	,
cord-356188-rwf78stz	51	6	and	and	CC
cord-356188-rwf78stz	51	7	studies	study	NNS
cord-356188-rwf78stz	51	8	in	in	IN
cord-356188-rwf78stz	51	9	healthy	healthy	JJ
cord-356188-rwf78stz	51	10	children	child	NNS
cord-356188-rwf78stz	51	11	Ͻ15	Ͻ15	NNP
cord-356188-rwf78stz	51	12	years	year	NNS
cord-356188-rwf78stz	51	13	of	of	IN
cord-356188-rwf78stz	51	14	age	age	NN
cord-356188-rwf78stz	51	15	have	have	VBP
cord-356188-rwf78stz	51	16	shown	show	VBN
cord-356188-rwf78stz	51	17	TIV	TIV	NNP
cord-356188-rwf78stz	51	18	efficacies	efficacy	NNS
cord-356188-rwf78stz	51	19	ranging	range	VBG
cord-356188-rwf78stz	51	20	from	from	IN
cord-356188-rwf78stz	51	21	31	31	CD
cord-356188-rwf78stz	51	22	%	%	NN
cord-356188-rwf78stz	51	23	to	to	TO
cord-356188-rwf78stz	51	24	90	90	CD
cord-356188-rwf78stz	51	25	%	%	NN
cord-356188-rwf78stz	51	26	(	(	-LRB-
cord-356188-rwf78stz	51	27	reviewed	review	VBN
cord-356188-rwf78stz	51	28	in	in	IN
cord-356188-rwf78stz	51	29	ref	ref	NN
cord-356188-rwf78stz	51	30	.	.	.
cord-356188-rwf78stz	52	1	[	[	-LRB-
cord-356188-rwf78stz	52	2	48	48	CD
cord-356188-rwf78stz	52	3	]	]	-RRB-
cord-356188-rwf78stz	52	4	)	)	-RRB-
cord-356188-rwf78stz	52	5	.	.	.
cord-356188-rwf78stz	53	1	Since	since	IN
cord-356188-rwf78stz	53	2	2010	2010	CD
cord-356188-rwf78stz	53	3	,	,	,
cord-356188-rwf78stz	53	4	universal	universal	JJ
cord-356188-rwf78stz	53	5	influenza	influenza	NN
cord-356188-rwf78stz	53	6	vaccination	vaccination	NN
cord-356188-rwf78stz	53	7	is	be	VBZ
cord-356188-rwf78stz	53	8	recommended	recommend	VBN
cord-356188-rwf78stz	53	9	,	,	,
cord-356188-rwf78stz	53	10	i.e.	i.e.	FW
cord-356188-rwf78stz	53	11	,	,	,
cord-356188-rwf78stz	53	12	for	for	IN
cord-356188-rwf78stz	53	13	all	all	DT
cord-356188-rwf78stz	53	14	individuals	individual	NNS
cord-356188-rwf78stz	53	15	at	at	IN
cord-356188-rwf78stz	53	16	least	least	JJS
cord-356188-rwf78stz	53	17	6	6	CD
cord-356188-rwf78stz	53	18	months	month	NNS
cord-356188-rwf78stz	53	19	of	of	IN
cord-356188-rwf78stz	53	20	age	age	NN
cord-356188-rwf78stz	53	21	,	,	,
cord-356188-rwf78stz	53	22	but	but	CC
cord-356188-rwf78stz	53	23	traditional	traditional	JJ
cord-356188-rwf78stz	53	24	efforts	effort	NNS
cord-356188-rwf78stz	53	25	remain	remain	VBP
cord-356188-rwf78stz	53	26	focused	focused	JJ
cord-356188-rwf78stz	53	27	on	on	IN
cord-356188-rwf78stz	53	28	those	those	DT
cord-356188-rwf78stz	53	29	individuals	individual	NNS
cord-356188-rwf78stz	53	30	at	at	IN
cord-356188-rwf78stz	53	31	greatest	great	JJS
cord-356188-rwf78stz	53	32	risk	risk	NN
cord-356188-rwf78stz	53	33	of	of	IN
cord-356188-rwf78stz	53	34	serious	serious	JJ
cord-356188-rwf78stz	53	35	disease	disease	NN
cord-356188-rwf78stz	53	36	:	:	:
cord-356188-rwf78stz	53	37	young	young	JJ
cord-356188-rwf78stz	53	38	children	child	NNS
cord-356188-rwf78stz	53	39	,	,	,
cord-356188-rwf78stz	53	40	elderly	elderly	JJ
cord-356188-rwf78stz	53	41	,	,	,
cord-356188-rwf78stz	53	42	individuals	individual	NNS
cord-356188-rwf78stz	53	43	with	with	IN
cord-356188-rwf78stz	53	44	pulmonary	pulmonary	JJ
cord-356188-rwf78stz	53	45	or	or	CC
cord-356188-rwf78stz	53	46	cardiovascular	cardiovascular	JJ
cord-356188-rwf78stz	53	47	disorders	disorder	NNS
cord-356188-rwf78stz	53	48	,	,	,
cord-356188-rwf78stz	53	49	and	and	CC
cord-356188-rwf78stz	53	50	those	those	DT
cord-356188-rwf78stz	53	51	who	who	WP
cord-356188-rwf78stz	53	52	are	be	VBP
cord-356188-rwf78stz	53	53	immunocompromised	immunocompromised	JJ
cord-356188-rwf78stz	53	54	or	or	CC
cord-356188-rwf78stz	53	55	pregnant	pregnant	JJ
cord-356188-rwf78stz	53	56	[	[	-LRB-
cord-356188-rwf78stz	53	57	35	35	CD
cord-356188-rwf78stz	53	58	]	]	-RRB-
cord-356188-rwf78stz	53	59	.	.	.
cord-356188-rwf78stz	54	1	Vaccination	vaccination	NN
cord-356188-rwf78stz	54	2	programs	program	NNS
cord-356188-rwf78stz	54	3	also	also	RB
cord-356188-rwf78stz	54	4	elicit	elicit	VBP
cord-356188-rwf78stz	54	5	indirect	indirect	JJ
cord-356188-rwf78stz	54	6	benefits	benefit	NNS
cord-356188-rwf78stz	54	7	,	,	,
cord-356188-rwf78stz	54	8	including	include	VBG
cord-356188-rwf78stz	54	9	herd	herd	NN
cord-356188-rwf78stz	54	10	immunity	immunity	NN
cord-356188-rwf78stz	54	11	,	,	,
cord-356188-rwf78stz	54	12	by	by	IN
cord-356188-rwf78stz	54	13	which	which	WDT
cord-356188-rwf78stz	54	14	immunized	immunize	VBD
cord-356188-rwf78stz	54	15	individuals	individual	NNS
cord-356188-rwf78stz	54	16	protect	protect	VBP
cord-356188-rwf78stz	54	17	those	those	DT
cord-356188-rwf78stz	54	18	who	who	WP
cord-356188-rwf78stz	54	19	are	be	VBP
cord-356188-rwf78stz	54	20	immunocompromised	immunocompromised	JJ
cord-356188-rwf78stz	54	21	or	or	CC
cord-356188-rwf78stz	54	22	other	other	JJ
cord-356188-rwf78stz	54	23	nonvaccinated	nonvaccinate	VBN
cord-356188-rwf78stz	54	24	individuals	individual	NNS
cord-356188-rwf78stz	54	25	[	[	-LRB-
cord-356188-rwf78stz	54	26	49	49	CD
cord-356188-rwf78stz	54	27	,	,	,
cord-356188-rwf78stz	54	28	50	50	CD
cord-356188-rwf78stz	54	29	]	]	-RRB-
cord-356188-rwf78stz	54	30	.	.	.
cord-356188-rwf78stz	55	1	This	this	DT
cord-356188-rwf78stz	55	2	effect	effect	NN
cord-356188-rwf78stz	55	3	was	be	VBD
cord-356188-rwf78stz	55	4	observed	observe	VBN
cord-356188-rwf78stz	55	5	in	in	IN
cord-356188-rwf78stz	55	6	a	a	DT
cord-356188-rwf78stz	55	7	retrospective	retrospective	JJ
cord-356188-rwf78stz	55	8	epidemiological	epidemiological	JJ
cord-356188-rwf78stz	55	9	study	study	NN
cord-356188-rwf78stz	55	10	in	in	IN
cord-356188-rwf78stz	55	11	Japan	Japan	NNP
cord-356188-rwf78stz	55	12	and	and	CC
cord-356188-rwf78stz	55	13	the	the	DT
cord-356188-rwf78stz	55	14	United	United	NNP
cord-356188-rwf78stz	55	15	States	States	NNP
cord-356188-rwf78stz	55	16	examining	examine	VBG
cord-356188-rwf78stz	55	17	mortality	mortality	NN
cord-356188-rwf78stz	55	18	and	and	CC
cord-356188-rwf78stz	55	19	influenza	influenza	NN
cord-356188-rwf78stz	55	20	vaccination	vaccination	NN
cord-356188-rwf78stz	55	21	rates	rate	NNS
cord-356188-rwf78stz	55	22	between	between	IN
cord-356188-rwf78stz	55	23	1949	1949	CD
cord-356188-rwf78stz	55	24	and	and	CC
cord-356188-rwf78stz	55	25	1998	1998	CD
cord-356188-rwf78stz	55	26	[	[	-LRB-
cord-356188-rwf78stz	55	27	51	51	CD
cord-356188-rwf78stz	55	28	]	]	-RRB-
cord-356188-rwf78stz	55	29	.	.	.
cord-356188-rwf78stz	56	1	As	as	IN
cord-356188-rwf78stz	56	2	children	child	NNS
cord-356188-rwf78stz	56	3	have	have	VBP
cord-356188-rwf78stz	56	4	long	long	RB
cord-356188-rwf78stz	56	5	been	be	VBN
cord-356188-rwf78stz	56	6	considered	consider	VBN
cord-356188-rwf78stz	56	7	to	to	TO
cord-356188-rwf78stz	56	8	have	have	VB
cord-356188-rwf78stz	56	9	an	an	DT
cord-356188-rwf78stz	56	10	important	important	JJ
cord-356188-rwf78stz	56	11	role	role	NN
cord-356188-rwf78stz	56	12	in	in	IN
cord-356188-rwf78stz	56	13	the	the	DT
cord-356188-rwf78stz	56	14	spread	spread	NN
cord-356188-rwf78stz	56	15	of	of	IN
cord-356188-rwf78stz	56	16	influenza	influenza	NN
cord-356188-rwf78stz	56	17	during	during	IN
cord-356188-rwf78stz	56	18	epidemics	epidemic	NNS
cord-356188-rwf78stz	56	19	[	[	-LRB-
cord-356188-rwf78stz	56	20	7	7	CD
cord-356188-rwf78stz	56	21	]	]	-RRB-
cord-356188-rwf78stz	56	22	[	[	-LRB-
cord-356188-rwf78stz	56	23	8	8	CD
cord-356188-rwf78stz	56	24	]	]	-RRB-
cord-356188-rwf78stz	56	25	[	[	-LRB-
cord-356188-rwf78stz	56	26	9	9	CD
cord-356188-rwf78stz	56	27	]	]	-RRB-
cord-356188-rwf78stz	56	28	,	,	,
cord-356188-rwf78stz	56	29	Japanese	japanese	JJ
cord-356188-rwf78stz	56	30	officials	official	NNS
cord-356188-rwf78stz	56	31	legislated	legislate	VBD
cord-356188-rwf78stz	56	32	compulsory	compulsory	JJ
cord-356188-rwf78stz	56	33	vaccination	vaccination	NN
cord-356188-rwf78stz	56	34	of	of	IN
cord-356188-rwf78stz	56	35	school	school	NN
cord-356188-rwf78stz	56	36	-	-	HYPH
cord-356188-rwf78stz	56	37	aged	age	VBN
cord-356188-rwf78stz	56	38	children	child	NNS
cord-356188-rwf78stz	56	39	in	in	IN
cord-356188-rwf78stz	56	40	1977	1977	CD
cord-356188-rwf78stz	56	41	,	,	,
cord-356188-rwf78stz	56	42	and	and	CC
cord-356188-rwf78stz	56	43	as	as	IN
cord-356188-rwf78stz	56	44	the	the	DT
cord-356188-rwf78stz	56	45	policy	policy	NN
cord-356188-rwf78stz	56	46	changed	change	VBD
cord-356188-rwf78stz	56	47	to	to	IN
cord-356188-rwf78stz	56	48	optional	optional	JJ
cord-356188-rwf78stz	56	49	immunization	immunization	NN
cord-356188-rwf78stz	56	50	in	in	IN
cord-356188-rwf78stz	56	51	1987	1987	CD
cord-356188-rwf78stz	56	52	,	,	,
cord-356188-rwf78stz	56	53	it	-PRON-	PRP
cord-356188-rwf78stz	56	54	became	become	VBD
cord-356188-rwf78stz	56	55	clear	clear	JJ
cord-356188-rwf78stz	56	56	that	that	IN
cord-356188-rwf78stz	56	57	mortality	mortality	NN
cord-356188-rwf78stz	56	58	rates	rate	NNS
cord-356188-rwf78stz	56	59	were	be	VBD
cord-356188-rwf78stz	56	60	inversely	inversely	RB
cord-356188-rwf78stz	56	61	correlated	correlate	VBN
cord-356188-rwf78stz	56	62	with	with	IN
cord-356188-rwf78stz	56	63	overall	overall	JJ
cord-356188-rwf78stz	56	64	vaccination	vaccination	NN
cord-356188-rwf78stz	56	65	coverage	coverage	NN
cord-356188-rwf78stz	56	66	.	.	.
cord-356188-rwf78stz	57	1	However	however	RB
cord-356188-rwf78stz	57	2	,	,	,
cord-356188-rwf78stz	57	3	recent	recent	JJ
cord-356188-rwf78stz	57	4	reviews	review	NNS
cord-356188-rwf78stz	57	5	of	of	IN
cord-356188-rwf78stz	57	6	vaccine	vaccine	NN
cord-356188-rwf78stz	57	7	studies	study	NNS
cord-356188-rwf78stz	57	8	in	in	IN
cord-356188-rwf78stz	57	9	various	various	JJ
cord-356188-rwf78stz	57	10	populations	population	NNS
cord-356188-rwf78stz	57	11	have	have	VBP
cord-356188-rwf78stz	57	12	concluded	conclude	VBN
cord-356188-rwf78stz	57	13	that	that	IN
cord-356188-rwf78stz	57	14	overestimation	overestimation	NN
cord-356188-rwf78stz	57	15	of	of	IN
cord-356188-rwf78stz	57	16	the	the	DT
cord-356188-rwf78stz	57	17	benefits	benefit	NNS
cord-356188-rwf78stz	57	18	of	of	IN
cord-356188-rwf78stz	57	19	vaccination	vaccination	NN
cord-356188-rwf78stz	57	20	is	be	VBZ
cord-356188-rwf78stz	57	21	common	common	JJ
cord-356188-rwf78stz	57	22	,	,	,
cord-356188-rwf78stz	57	23	particularly	particularly	RB
cord-356188-rwf78stz	57	24	within	within	IN
cord-356188-rwf78stz	57	25	the	the	DT
cord-356188-rwf78stz	57	26	elderly	elderly	JJ
cord-356188-rwf78stz	57	27	population	population	NN
cord-356188-rwf78stz	57	28	[	[	-LRB-
cord-356188-rwf78stz	57	29	52	52	CD
cord-356188-rwf78stz	57	30	,	,	,
cord-356188-rwf78stz	57	31	53	53	CD
cord-356188-rwf78stz	57	32	]	]	-RRB-
cord-356188-rwf78stz	57	33	,	,	,
cord-356188-rwf78stz	57	34	but	but	CC
cord-356188-rwf78stz	57	35	studies	study	NNS
cord-356188-rwf78stz	57	36	that	that	WDT
cord-356188-rwf78stz	57	37	take	take	VBP
cord-356188-rwf78stz	57	38	into	into	IN
cord-356188-rwf78stz	57	39	account	account	NN
cord-356188-rwf78stz	57	40	selection	selection	NN
cord-356188-rwf78stz	57	41	biases	bias	NNS
cord-356188-rwf78stz	57	42	do	do	VBP
cord-356188-rwf78stz	57	43	suggest	suggest	VB
cord-356188-rwf78stz	57	44	that	that	IN
cord-356188-rwf78stz	57	45	vaccination	vaccination	NN
cord-356188-rwf78stz	57	46	is	be	VBZ
cord-356188-rwf78stz	57	47	associated	associate	VBN
cord-356188-rwf78stz	57	48	with	with	IN
cord-356188-rwf78stz	57	49	lower	low	JJR
cord-356188-rwf78stz	57	50	risk	risk	NN
cord-356188-rwf78stz	57	51	of	of	IN
cord-356188-rwf78stz	57	52	hospitalization	hospitalization	NN
cord-356188-rwf78stz	57	53	for	for	IN
cord-356188-rwf78stz	57	54	pneumonia	pneumonia	NN
cord-356188-rwf78stz	57	55	or	or	CC
cord-356188-rwf78stz	57	56	influenza	influenza	NN
cord-356188-rwf78stz	57	57	,	,	,
cord-356188-rwf78stz	57	58	as	as	RB
cord-356188-rwf78stz	57	59	well	well	RB
cord-356188-rwf78stz	57	60	as	as	IN
cord-356188-rwf78stz	57	61	all	all	RB
cord-356188-rwf78stz	57	62	-	-	HYPH
cord-356188-rwf78stz	57	63	cause	cause	NN
cord-356188-rwf78stz	57	64	mortality	mortality	NN
cord-356188-rwf78stz	57	65	[	[	-LRB-
cord-356188-rwf78stz	57	66	52	52	CD
cord-356188-rwf78stz	57	67	,	,	,
cord-356188-rwf78stz	57	68	54	54	CD
cord-356188-rwf78stz	57	69	,	,	,
cord-356188-rwf78stz	57	70	55	55	CD
cord-356188-rwf78stz	57	71	]	]	-RRB-
cord-356188-rwf78stz	57	72	.	.	.
cord-356188-rwf78stz	58	1	Furthermore	furthermore	RB
cord-356188-rwf78stz	58	2	,	,	,
cord-356188-rwf78stz	58	3	in	in	IN
cord-356188-rwf78stz	58	4	October	October	NNP
cord-356188-rwf78stz	58	5	2009	2009	CD
cord-356188-rwf78stz	58	6	,	,	,
cord-356188-rwf78stz	58	7	the	the	DT
cord-356188-rwf78stz	58	8	United	United	NNP
cord-356188-rwf78stz	58	9	States	States	NNP
cord-356188-rwf78stz	58	10	commenced	commence	VBD
cord-356188-rwf78stz	58	11	a	a	DT
cord-356188-rwf78stz	58	12	national	national	JJ
cord-356188-rwf78stz	58	13	influenza	influenza	NN
cord-356188-rwf78stz	58	14	H1N1/2009	h1n1/2009	NN
cord-356188-rwf78stz	58	15	vaccination	vaccination	NN
cord-356188-rwf78stz	58	16	campaign	campaign	NN
cord-356188-rwf78stz	58	17	,	,	,
cord-356188-rwf78stz	58	18	and	and	CC
cord-356188-rwf78stz	58	19	it	-PRON-	PRP
cord-356188-rwf78stz	58	20	is	be	VBZ
cord-356188-rwf78stz	58	21	estimated	estimate	VBN
cord-356188-rwf78stz	58	22	that	that	IN
cord-356188-rwf78stz	58	23	ϳ41.2	ϳ41.2	NN
cord-356188-rwf78stz	58	24	%	%	NN
cord-356188-rwf78stz	58	25	and	and	CC
cord-356188-rwf78stz	58	26	43	43	CD
cord-356188-rwf78stz	58	27	%	%	NN
cord-356188-rwf78stz	58	28	of	of	IN
cord-356188-rwf78stz	58	29	the	the	DT
cord-356188-rwf78stz	58	30	U.S.	U.S.	NNP
cord-356188-rwf78stz	58	31	population	population	NN
cord-356188-rwf78stz	58	32	received	receive	VBD
cord-356188-rwf78stz	58	33	the	the	DT
cord-356188-rwf78stz	58	34	2009	2009	CD
cord-356188-rwf78stz	58	35	-2010	-2010	NN
cord-356188-rwf78stz	58	36	and	and	CC
cord-356188-rwf78stz	58	37	2010	2010	CD
cord-356188-rwf78stz	58	38	-2011	-2011	NN
cord-356188-rwf78stz	58	39	influenza	influenza	NN
cord-356188-rwf78stz	58	40	vaccines	vaccine	NNS
cord-356188-rwf78stz	58	41	,	,	,
cord-356188-rwf78stz	58	42	respectively	respectively	RB
cord-356188-rwf78stz	58	43	[	[	-LRB-
cord-356188-rwf78stz	58	44	56	56	CD
cord-356188-rwf78stz	58	45	]	]	-RRB-
cord-356188-rwf78stz	58	46	.	.	.
cord-356188-rwf78stz	59	1	Following	follow	VBG
cord-356188-rwf78stz	59	2	implementation	implementation	NN
cord-356188-rwf78stz	59	3	of	of	IN
cord-356188-rwf78stz	59	4	this	this	DT
cord-356188-rwf78stz	59	5	campaign	campaign	NN
cord-356188-rwf78stz	59	6	,	,	,
cord-356188-rwf78stz	59	7	the	the	DT
cord-356188-rwf78stz	59	8	frequency	frequency	NN
cord-356188-rwf78stz	59	9	of	of	IN
cord-356188-rwf78stz	59	10	positive	positive	JJ
cord-356188-rwf78stz	59	11	influenza	influenza	NN
cord-356188-rwf78stz	59	12	cultures	culture	NNS
cord-356188-rwf78stz	59	13	reported	report	VBN
cord-356188-rwf78stz	59	14	to	to	IN
cord-356188-rwf78stz	59	15	the	the	DT
cord-356188-rwf78stz	59	16	CDC	CDC	NNP
cord-356188-rwf78stz	59	17	declined	decline	VBD
cord-356188-rwf78stz	59	18	quickly	quickly	RB
cord-356188-rwf78stz	59	19	.	.	.
cord-356188-rwf78stz	60	1	Immunization	immunization	NN
cord-356188-rwf78stz	60	2	and	and	CC
cord-356188-rwf78stz	60	3	herd	herd	NN
cord-356188-rwf78stz	60	4	immunity	immunity	NN
cord-356188-rwf78stz	60	5	resulting	result	VBG
cord-356188-rwf78stz	60	6	from	from	IN
cord-356188-rwf78stz	60	7	prior	prior	JJ
cord-356188-rwf78stz	60	8	exposure	exposure	NN
cord-356188-rwf78stz	60	9	of	of	IN
cord-356188-rwf78stz	60	10	A(H1N1)pdm09	A(H1N1)pdm09	NNP
cord-356188-rwf78stz	60	11	likely	likely	RB
cord-356188-rwf78stz	60	12	resulted	result	VBD
cord-356188-rwf78stz	60	13	in	in	IN
cord-356188-rwf78stz	60	14	decreased	decrease	VBN
cord-356188-rwf78stz	60	15	cases	case	NNS
cord-356188-rwf78stz	60	16	of	of	IN
cord-356188-rwf78stz	60	17	influenza	influenza	NN
cord-356188-rwf78stz	60	18	during	during	IN
cord-356188-rwf78stz	60	19	the	the	DT
cord-356188-rwf78stz	60	20	2010	2010	CD
cord-356188-rwf78stz	60	21	-2011	-2011	NN
cord-356188-rwf78stz	60	22	influenza	influenza	NN
cord-356188-rwf78stz	60	23	season	season	NN
cord-356188-rwf78stz	60	24	.	.	.
cord-356188-rwf78stz	61	1	Undoubtedly	undoubtedly	RB
cord-356188-rwf78stz	61	2	,	,	,
cord-356188-rwf78stz	61	3	influenza	influenza	NN
cord-356188-rwf78stz	61	4	vaccines	vaccine	NNS
cord-356188-rwf78stz	61	5	can	can	MD
cord-356188-rwf78stz	61	6	be	be	VB
cord-356188-rwf78stz	61	7	improved	improve	VBN
cord-356188-rwf78stz	61	8	,	,	,
cord-356188-rwf78stz	61	9	particularly	particularly	RB
cord-356188-rwf78stz	61	10	for	for	IN
cord-356188-rwf78stz	61	11	the	the	DT
cord-356188-rwf78stz	61	12	most	most	RBS
cord-356188-rwf78stz	61	13	vulnerable	vulnerable	JJ
cord-356188-rwf78stz	61	14	populations	population	NNS
cord-356188-rwf78stz	61	15	.	.	.
cord-356188-rwf78stz	62	1	Continuous	continuous	JJ
cord-356188-rwf78stz	62	2	epidemiological	epidemiological	JJ
cord-356188-rwf78stz	62	3	surveillance	surveillance	NN
cord-356188-rwf78stz	62	4	of	of	IN
cord-356188-rwf78stz	62	5	circulating	circulate	VBG
cord-356188-rwf78stz	62	6	influenza	influenza	NN
cord-356188-rwf78stz	62	7	strains	strain	NNS
cord-356188-rwf78stz	62	8	is	be	VBZ
cord-356188-rwf78stz	62	9	required	require	VBN
cord-356188-rwf78stz	62	10	for	for	IN
cord-356188-rwf78stz	62	11	keeping	keep	VBG
cord-356188-rwf78stz	62	12	pace	pace	NN
cord-356188-rwf78stz	62	13	with	with	IN
cord-356188-rwf78stz	62	14	antigenic	antigenic	JJ
cord-356188-rwf78stz	62	15	drift	drift	NN
cord-356188-rwf78stz	62	16	and	and	CC
cord-356188-rwf78stz	62	17	shift	shift	NN
cord-356188-rwf78stz	62	18	(	(	-LRB-
cord-356188-rwf78stz	62	19	reviewed	review	VBN
cord-356188-rwf78stz	62	20	in	in	IN
cord-356188-rwf78stz	62	21	ref	ref	NN
cord-356188-rwf78stz	62	22	.	.	.
cord-356188-rwf78stz	63	1	[	[	-LRB-
cord-356188-rwf78stz	63	2	57	57	CD
cord-356188-rwf78stz	63	3	]	]	-RRB-
cord-356188-rwf78stz	63	4	)	)	-RRB-
cord-356188-rwf78stz	63	5	.	.	.
cord-356188-rwf78stz	64	1	Antigenic	antigenic	JJ
cord-356188-rwf78stz	64	2	drift	drift	NN
cord-356188-rwf78stz	64	3	is	be	VBZ
cord-356188-rwf78stz	64	4	an	an	DT
cord-356188-rwf78stz	64	5	endless	endless	JJ
cord-356188-rwf78stz	64	6	battle	battle	NN
cord-356188-rwf78stz	64	7	,	,	,
cord-356188-rwf78stz	64	8	whereby	whereby	WRB
cord-356188-rwf78stz	64	9	viral	viral	JJ
cord-356188-rwf78stz	64	10	variants	variant	NNS
cord-356188-rwf78stz	64	11	emerge	emerge	VBP
cord-356188-rwf78stz	64	12	as	as	IN
cord-356188-rwf78stz	64	13	a	a	DT
cord-356188-rwf78stz	64	14	result	result	NN
cord-356188-rwf78stz	64	15	of	of	IN
cord-356188-rwf78stz	64	16	point	point	NN
cord-356188-rwf78stz	64	17	mutations	mutation	NNS
cord-356188-rwf78stz	64	18	within	within	IN
cord-356188-rwf78stz	64	19	the	the	DT
cord-356188-rwf78stz	64	20	viral	viral	JJ
cord-356188-rwf78stz	64	21	genome	genome	NN
cord-356188-rwf78stz	64	22	,	,	,
cord-356188-rwf78stz	64	23	escaping	escape	VBG
cord-356188-rwf78stz	64	24	antibody	antibody	NN
cord-356188-rwf78stz	64	25	-	-	HYPH
cord-356188-rwf78stz	64	26	mediated	mediate	VBN
cord-356188-rwf78stz	64	27	viral	viral	JJ
cord-356188-rwf78stz	64	28	neutralization	neutralization	NN
cord-356188-rwf78stz	64	29	.	.	.
cord-356188-rwf78stz	65	1	Whereas	whereas	IN
cord-356188-rwf78stz	65	2	many	many	JJ
cord-356188-rwf78stz	65	3	mutations	mutation	NNS
cord-356188-rwf78stz	65	4	occur	occur	VBP
cord-356188-rwf78stz	65	5	throughout	throughout	IN
cord-356188-rwf78stz	65	6	the	the	DT
cord-356188-rwf78stz	65	7	viral	viral	JJ
cord-356188-rwf78stz	65	8	genome	genome	NN
cord-356188-rwf78stz	65	9	,	,	,
cord-356188-rwf78stz	65	10	the	the	DT
cord-356188-rwf78stz	65	11	point	point	NN
cord-356188-rwf78stz	65	12	mutations	mutation	NNS
cord-356188-rwf78stz	65	13	within	within	IN
cord-356188-rwf78stz	65	14	the	the	DT
cord-356188-rwf78stz	65	15	HA	HA	NNP
cord-356188-rwf78stz	65	16	or	or	CC
cord-356188-rwf78stz	65	17	NA	NA	NNP
cord-356188-rwf78stz	65	18	proteins	protein	NNS
cord-356188-rwf78stz	65	19	can	can	MD
cord-356188-rwf78stz	65	20	change	change	VB
cord-356188-rwf78stz	65	21	antibody	antibody	NN
cord-356188-rwf78stz	65	22	-	-	HYPH
cord-356188-rwf78stz	65	23	binding	bind	VBG
cord-356188-rwf78stz	65	24	domains	domain	NNS
cord-356188-rwf78stz	65	25	,	,	,
cord-356188-rwf78stz	65	26	such	such	JJ
cord-356188-rwf78stz	65	27	that	that	IN
cord-356188-rwf78stz	65	28	individuals	individual	NNS
cord-356188-rwf78stz	65	29	no	no	RB
cord-356188-rwf78stz	65	30	longer	longer	RB
cord-356188-rwf78stz	65	31	have	have	VBP
cord-356188-rwf78stz	65	32	adequate	adequate	JJ
cord-356188-rwf78stz	65	33	,	,	,
cord-356188-rwf78stz	65	34	protective	protective	JJ
cord-356188-rwf78stz	65	35	B	b	NN
cord-356188-rwf78stz	65	36	cell	cell	NN
cord-356188-rwf78stz	65	37	memory	memory	NN
cord-356188-rwf78stz	65	38	responses	response	NNS
cord-356188-rwf78stz	65	39	.	.	.
cord-356188-rwf78stz	66	1	In	in	IN
cord-356188-rwf78stz	66	2	contrast	contrast	NN
cord-356188-rwf78stz	66	3	,	,	,
cord-356188-rwf78stz	66	4	major	major	JJ
cord-356188-rwf78stz	66	5	qualitative	qualitative	JJ
cord-356188-rwf78stz	66	6	changes	change	NNS
cord-356188-rwf78stz	66	7	in	in	IN
cord-356188-rwf78stz	66	8	antigenicity	antigenicity	NN
cord-356188-rwf78stz	66	9	as	as	IN
cord-356188-rwf78stz	66	10	a	a	DT
cord-356188-rwf78stz	66	11	result	result	NN
cord-356188-rwf78stz	66	12	of	of	IN
cord-356188-rwf78stz	66	13	antigenic	antigenic	JJ
cord-356188-rwf78stz	66	14	shift	shift	NN
cord-356188-rwf78stz	66	15	occur	occur	VBP
cord-356188-rwf78stz	66	16	as	as	IN
cord-356188-rwf78stz	66	17	a	a	DT
cord-356188-rwf78stz	66	18	result	result	NN
cord-356188-rwf78stz	66	19	of	of	IN
cord-356188-rwf78stz	66	20	genetic	genetic	JJ
cord-356188-rwf78stz	66	21	reassortment	reassortment	NN
cord-356188-rwf78stz	66	22	and	and	CC
cord-356188-rwf78stz	66	23	replacement	replacement	NN
cord-356188-rwf78stz	66	24	of	of	IN
cord-356188-rwf78stz	66	25	one	one	CD
cord-356188-rwf78stz	66	26	or	or	CC
cord-356188-rwf78stz	66	27	more	more	JJR
cord-356188-rwf78stz	66	28	influenza	influenza	NN
cord-356188-rwf78stz	66	29	gene	gene	NN
cord-356188-rwf78stz	66	30	segments	segment	NNS
cord-356188-rwf78stz	66	31	.	.	.
cord-356188-rwf78stz	67	1	This	this	DT
cord-356188-rwf78stz	67	2	,	,	,
cord-356188-rwf78stz	67	3	in	in	IN
cord-356188-rwf78stz	67	4	turn	turn	NN
cord-356188-rwf78stz	67	5	,	,	,
cord-356188-rwf78stz	67	6	creates	create	VBZ
cord-356188-rwf78stz	67	7	a	a	DT
cord-356188-rwf78stz	67	8	new	new	JJ
cord-356188-rwf78stz	67	9	influenza	influenza	NN
cord-356188-rwf78stz	67	10	virus	virus	NN
cord-356188-rwf78stz	67	11	subtype	subtype	NN
cord-356188-rwf78stz	67	12	,	,	,
cord-356188-rwf78stz	67	13	to	to	TO
cord-356188-rwf78stz	67	14	which	which	WDT
cord-356188-rwf78stz	67	15	little	little	JJ
cord-356188-rwf78stz	67	16	or	or	CC
cord-356188-rwf78stz	67	17	no	no	DT
cord-356188-rwf78stz	67	18	immunity	immunity	NN
cord-356188-rwf78stz	67	19	may	may	MD
cord-356188-rwf78stz	67	20	exist	exist	VB
cord-356188-rwf78stz	67	21	within	within	IN
cord-356188-rwf78stz	67	22	the	the	DT
cord-356188-rwf78stz	67	23	population	population	NN
cord-356188-rwf78stz	67	24	.	.	.
cord-356188-rwf78stz	68	1	Antigenic	antigenic	JJ
cord-356188-rwf78stz	68	2	shift	shift	NN
cord-356188-rwf78stz	68	3	remains	remain	VBZ
cord-356188-rwf78stz	68	4	a	a	DT
cord-356188-rwf78stz	68	5	chief	chief	JJ
cord-356188-rwf78stz	68	6	concern	concern	NN
cord-356188-rwf78stz	68	7	,	,	,
cord-356188-rwf78stz	68	8	in	in	IN
cord-356188-rwf78stz	68	9	that	that	DT
cord-356188-rwf78stz	68	10	highly	highly	RB
cord-356188-rwf78stz	68	11	pathogenic	pathogenic	JJ
cord-356188-rwf78stz	68	12	influenza	influenza	NN
cord-356188-rwf78stz	68	13	viruses	virus	NNS
cord-356188-rwf78stz	68	14	could	could	MD
cord-356188-rwf78stz	68	15	potentially	potentially	RB
cord-356188-rwf78stz	68	16	gain	gain	VB
cord-356188-rwf78stz	68	17	efficient	efficient	JJ
cord-356188-rwf78stz	68	18	human	human	NN
cord-356188-rwf78stz	68	19	-	-	HYPH
cord-356188-rwf78stz	68	20	to	to	IN
cord-356188-rwf78stz	68	21	-	-	HYPH
cord-356188-rwf78stz	68	22	human	human	JJ
cord-356188-rwf78stz	68	23	transmission	transmission	NN
cord-356188-rwf78stz	68	24	.	.	.
cord-356188-rwf78stz	69	1	As	as	IN
cord-356188-rwf78stz	69	2	influenza	influenza	NN
cord-356188-rwf78stz	69	3	viruses	virus	NNS
cord-356188-rwf78stz	69	4	frequently	frequently	RB
cord-356188-rwf78stz	69	5	undergo	undergo	VBP
cord-356188-rwf78stz	69	6	antigenic	antigenic	JJ
cord-356188-rwf78stz	69	7	drift	drift	NN
cord-356188-rwf78stz	69	8	and	and	CC
cord-356188-rwf78stz	69	9	less	less	RBR
cord-356188-rwf78stz	69	10	frequently	frequently	RB
cord-356188-rwf78stz	69	11	,	,	,
cord-356188-rwf78stz	69	12	shift	shift	VBP
cord-356188-rwf78stz	69	13	,	,	,
cord-356188-rwf78stz	69	14	a	a	DT
cord-356188-rwf78stz	69	15	desirable	desirable	JJ
cord-356188-rwf78stz	69	16	vaccine	vaccine	NN
cord-356188-rwf78stz	69	17	candidate	candidate	NN
cord-356188-rwf78stz	69	18	would	would	MD
cord-356188-rwf78stz	69	19	be	be	VB
cord-356188-rwf78stz	69	20	able	able	JJ
cord-356188-rwf78stz	69	21	to	to	TO
cord-356188-rwf78stz	69	22	induce	induce	VB
cord-356188-rwf78stz	69	23	highly	highly	RB
cord-356188-rwf78stz	69	24	specific	specific	JJ
cord-356188-rwf78stz	69	25	,	,	,
cord-356188-rwf78stz	69	26	cross	cross	JJ
cord-356188-rwf78stz	69	27	-	-	JJ
cord-356188-rwf78stz	69	28	reactive	reactive	JJ
cord-356188-rwf78stz	69	29	antibodies	antibody	NNS
cord-356188-rwf78stz	69	30	and	and	CC
cord-356188-rwf78stz	69	31	T	T	NNP
cord-356188-rwf78stz	69	32	cell	cell	NN
cord-356188-rwf78stz	69	33	responses	response	NNS
cord-356188-rwf78stz	69	34	.	.	.
cord-356188-rwf78stz	70	1	One	one	CD
cord-356188-rwf78stz	70	2	strategy	strategy	NN
cord-356188-rwf78stz	70	3	used	use	VBN
cord-356188-rwf78stz	70	4	in	in	IN
cord-356188-rwf78stz	70	5	vaccine	vaccine	NN
cord-356188-rwf78stz	70	6	improvement	improvement	NN
cord-356188-rwf78stz	70	7	includes	include	VBZ
cord-356188-rwf78stz	70	8	the	the	DT
cord-356188-rwf78stz	70	9	use	use	NN
cord-356188-rwf78stz	70	10	of	of	IN
cord-356188-rwf78stz	70	11	adjuvant	adjuvant	NN
cord-356188-rwf78stz	70	12	to	to	TO
cord-356188-rwf78stz	70	13	increase	increase	VB
cord-356188-rwf78stz	70	14	antigen	antigen	NN
cord-356188-rwf78stz	70	15	uptake	uptake	NN
cord-356188-rwf78stz	70	16	by	by	IN
cord-356188-rwf78stz	70	17	APCs	apc	NNS
cord-356188-rwf78stz	70	18	and	and	CC
cord-356188-rwf78stz	70	19	enhance	enhance	VB
cord-356188-rwf78stz	70	20	cytokine	cytokine	NN
cord-356188-rwf78stz	70	21	production	production	NN
cord-356188-rwf78stz	70	22	.	.	.
cord-356188-rwf78stz	71	1	Neither	neither	DT
cord-356188-rwf78stz	71	2	of	of	IN
cord-356188-rwf78stz	71	3	the	the	DT
cord-356188-rwf78stz	71	4	U.S.-licensed	u.s.-licensed	JJ
cord-356188-rwf78stz	71	5	TIVs	tiv	NNS
cord-356188-rwf78stz	71	6	nor	nor	CC
cord-356188-rwf78stz	71	7	LAIV	LAIV	NNP
cord-356188-rwf78stz	71	8	include	include	VBP
cord-356188-rwf78stz	71	9	adjuvant	adjuvant	JJ
cord-356188-rwf78stz	71	10	,	,	,
cord-356188-rwf78stz	71	11	but	but	CC
cord-356188-rwf78stz	71	12	there	there	EX
cord-356188-rwf78stz	71	13	are	be	VBP
cord-356188-rwf78stz	71	14	several	several	JJ
cord-356188-rwf78stz	71	15	licensed	license	VBN
cord-356188-rwf78stz	71	16	vaccines	vaccine	NNS
cord-356188-rwf78stz	71	17	available	available	JJ
cord-356188-rwf78stz	71	18	outside	outside	RB
cord-356188-rwf78stz	71	19	of	of	IN
cord-356188-rwf78stz	71	20	the	the	DT
cord-356188-rwf78stz	71	21	United	United	NNP
cord-356188-rwf78stz	71	22	States	States	NNP
cord-356188-rwf78stz	71	23	that	that	WDT
cord-356188-rwf78stz	71	24	use	use	VBP
cord-356188-rwf78stz	71	25	oil	oil	NN
cord-356188-rwf78stz	71	26	and	and	CC
cord-356188-rwf78stz	71	27	water	water	NN
cord-356188-rwf78stz	71	28	emulsions	emulsion	NNS
cord-356188-rwf78stz	71	29	for	for	IN
cord-356188-rwf78stz	71	30	seasonal	seasonal	JJ
cord-356188-rwf78stz	71	31	influenza	influenza	NN
cord-356188-rwf78stz	71	32	as	as	RB
cord-356188-rwf78stz	71	33	well	well	RB
cord-356188-rwf78stz	71	34	as	as	IN
cord-356188-rwf78stz	71	35	for	for	IN
cord-356188-rwf78stz	71	36	A	A	NNP
cord-356188-rwf78stz	71	37	/	/	SYM
cord-356188-rwf78stz	71	38	H5N1	H5N1	NNP
cord-356188-rwf78stz	71	39	(	(	-LRB-
cord-356188-rwf78stz	71	40	reviewed	review	VBN
cord-356188-rwf78stz	71	41	in	in	IN
cord-356188-rwf78stz	71	42	ref	ref	NN
cord-356188-rwf78stz	71	43	.	.	.
cord-356188-rwf78stz	72	1	[	[	-LRB-
cord-356188-rwf78stz	72	2	58	58	CD
cord-356188-rwf78stz	72	3	]	]	-RRB-
cord-356188-rwf78stz	72	4	)	)	-RRB-
cord-356188-rwf78stz	72	5	.	.	.
cord-356188-rwf78stz	73	1	For	for	IN
cord-356188-rwf78stz	73	2	instance	instance	NN
cord-356188-rwf78stz	73	3	,	,	,
cord-356188-rwf78stz	73	4	Novartis	Novartis	NNP
cord-356188-rwf78stz	73	5	Vaccines	Vaccines	NNP
cord-356188-rwf78stz	73	6	and	and	CC
cord-356188-rwf78stz	73	7	Diagnostics	Diagnostics	NNPS
cord-356188-rwf78stz	73	8	(	(	-LRB-
cord-356188-rwf78stz	73	9	Switzerland	Switzerland	NNP
cord-356188-rwf78stz	73	10	)	)	-RRB-
cord-356188-rwf78stz	73	11	manufactures	manufacture	VBZ
cord-356188-rwf78stz	73	12	Fluad	Fluad	NNP
cord-356188-rwf78stz	73	13	using	use	VBG
cord-356188-rwf78stz	73	14	MF59	MF59	NNP
cord-356188-rwf78stz	73	15	adjuvant	adjuvant	NN
cord-356188-rwf78stz	73	16	,	,	,
cord-356188-rwf78stz	73	17	and	and	CC
cord-356188-rwf78stz	73	18	GlaxoSmithKline	GlaxoSmithKline	NNP
cord-356188-rwf78stz	73	19	Biologicals	Biologicals	NNP
cord-356188-rwf78stz	73	20	(	(	-LRB-
cord-356188-rwf78stz	73	21	Belgium	Belgium	NNP
cord-356188-rwf78stz	73	22	)	)	-RRB-
cord-356188-rwf78stz	73	23	produces	produce	VBZ
cord-356188-rwf78stz	73	24	Pandemrix	Pandemrix	NNP
cord-356188-rwf78stz	73	25	,	,	,
cord-356188-rwf78stz	73	26	which	which	WDT
cord-356188-rwf78stz	73	27	includes	include	VBZ
cord-356188-rwf78stz	73	28	AS03	AS03	NNP
cord-356188-rwf78stz	73	29	.	.	.
cord-356188-rwf78stz	74	1	Fluad	Fluad	NNP
cord-356188-rwf78stz	74	2	has	have	VBZ
cord-356188-rwf78stz	74	3	been	be	VBN
cord-356188-rwf78stz	74	4	used	use	VBN
cord-356188-rwf78stz	74	5	in	in	IN
cord-356188-rwf78stz	74	6	Europe	Europe	NNP
cord-356188-rwf78stz	74	7	since	since	IN
cord-356188-rwf78stz	74	8	1997	1997	CD
cord-356188-rwf78stz	74	9	and	and	CC
cord-356188-rwf78stz	74	10	was	be	VBD
cord-356188-rwf78stz	74	11	recently	recently	RB
cord-356188-rwf78stz	74	12	approved	approve	VBN
cord-356188-rwf78stz	74	13	for	for	IN
cord-356188-rwf78stz	74	14	use	use	NN
cord-356188-rwf78stz	74	15	in	in	IN
cord-356188-rwf78stz	74	16	Canada	Canada	NNP
cord-356188-rwf78stz	74	17	in	in	IN
cord-356188-rwf78stz	74	18	adults	adult	NNS
cord-356188-rwf78stz	74	19	65	65	CD
cord-356188-rwf78stz	74	20	years	year	NNS
cord-356188-rwf78stz	74	21	and	and	CC
cord-356188-rwf78stz	74	22	older	old	JJR
cord-356188-rwf78stz	74	23	.	.	.
cord-356188-rwf78stz	75	1	MF59	MF59	NNP
cord-356188-rwf78stz	75	2	and	and	CC
cord-356188-rwf78stz	75	3	AS03	AS03	NNP
cord-356188-rwf78stz	75	4	are	be	VBP
cord-356188-rwf78stz	75	5	both	both	DT
cord-356188-rwf78stz	75	6	squalene	squalene	NN
cord-356188-rwf78stz	75	7	-	-	HYPH
cord-356188-rwf78stz	75	8	based	base	VBN
cord-356188-rwf78stz	75	9	with	with	IN
cord-356188-rwf78stz	75	10	surfactants	surfactant	NNS
cord-356188-rwf78stz	75	11	included	include	VBN
cord-356188-rwf78stz	75	12	to	to	TO
cord-356188-rwf78stz	75	13	stabilize	stabilize	VB
cord-356188-rwf78stz	75	14	the	the	DT
cord-356188-rwf78stz	75	15	emulsions	emulsion	NNS
cord-356188-rwf78stz	75	16	.	.	.
cord-356188-rwf78stz	76	1	Clinical	clinical	JJ
cord-356188-rwf78stz	76	2	trials	trial	NNS
cord-356188-rwf78stz	76	3	of	of	IN
cord-356188-rwf78stz	76	4	MF59-adjuvanted	mf59-adjuvanted	JJ
cord-356188-rwf78stz	76	5	vaccines	vaccine	NNS
cord-356188-rwf78stz	76	6	are	be	VBP
cord-356188-rwf78stz	76	7	well	well	RB
cord-356188-rwf78stz	76	8	-	-	HYPH
cord-356188-rwf78stz	76	9	tolerated	tolerate	VBN
cord-356188-rwf78stz	76	10	and	and	CC
cord-356188-rwf78stz	76	11	elicit	elicit	VB
cord-356188-rwf78stz	76	12	higher	high	JJR
cord-356188-rwf78stz	76	13	antibody	antibody	NN
cord-356188-rwf78stz	76	14	responses	response	NNS
cord-356188-rwf78stz	76	15	in	in	IN
cord-356188-rwf78stz	76	16	adults	adult	NNS
cord-356188-rwf78stz	76	17	[	[	-LRB-
cord-356188-rwf78stz	76	18	59	59	CD
cord-356188-rwf78stz	76	19	-61	-61	NNP
cord-356188-rwf78stz	76	20	]	]	-RRB-
cord-356188-rwf78stz	76	21	and	and	CC
cord-356188-rwf78stz	76	22	in	in	IN
cord-356188-rwf78stz	76	23	children	child	NNS
cord-356188-rwf78stz	76	24	[	[	-LRB-
cord-356188-rwf78stz	76	25	62	62	CD
cord-356188-rwf78stz	76	26	]	]	-RRB-
cord-356188-rwf78stz	76	27	[	[	-LRB-
cord-356188-rwf78stz	76	28	63	63	CD
cord-356188-rwf78stz	76	29	]	]	-RRB-
cord-356188-rwf78stz	76	30	[	[	-LRB-
cord-356188-rwf78stz	76	31	64	64	CD
cord-356188-rwf78stz	76	32	]	]	-RRB-
cord-356188-rwf78stz	76	33	compared	compare	VBN
cord-356188-rwf78stz	76	34	with	with	IN
cord-356188-rwf78stz	76	35	unadjuvanted	unadjuvanted	JJ
cord-356188-rwf78stz	76	36	vaccine	vaccine	NN
cord-356188-rwf78stz	76	37	preparations	preparation	NNS
cord-356188-rwf78stz	76	38	.	.	.
cord-356188-rwf78stz	77	1	The	the	DT
cord-356188-rwf78stz	77	2	concept	concept	NN
cord-356188-rwf78stz	77	3	of	of	IN
cord-356188-rwf78stz	77	4	a	a	DT
cord-356188-rwf78stz	77	5	universal	universal	JJ
cord-356188-rwf78stz	77	6	influenza	influenza	NN
cord-356188-rwf78stz	77	7	vaccine	vaccine	NN
cord-356188-rwf78stz	77	8	,	,	,
cord-356188-rwf78stz	77	9	where	where	WRB
cord-356188-rwf78stz	77	10	one	one	CD
cord-356188-rwf78stz	77	11	vaccine	vaccine	NN
cord-356188-rwf78stz	77	12	elicits	elicit	VBZ
cord-356188-rwf78stz	77	13	protection	protection	NN
cord-356188-rwf78stz	77	14	against	against	IN
cord-356188-rwf78stz	77	15	multiple	multiple	JJ
cord-356188-rwf78stz	77	16	influenza	influenza	NN
cord-356188-rwf78stz	77	17	subtypes	subtype	NNS
cord-356188-rwf78stz	77	18	,	,	,
cord-356188-rwf78stz	77	19	is	be	VBZ
cord-356188-rwf78stz	77	20	becoming	become	VBG
cord-356188-rwf78stz	77	21	a	a	DT
cord-356188-rwf78stz	77	22	reality	reality	NN
cord-356188-rwf78stz	77	23	.	.	.
cord-356188-rwf78stz	78	1	The	the	DT
cord-356188-rwf78stz	78	2	influenza	influenza	NN
cord-356188-rwf78stz	78	3	M2	M2	NNP
cord-356188-rwf78stz	78	4	ion	ion	NN
cord-356188-rwf78stz	78	5	channel	channel	NN
cord-356188-rwf78stz	78	6	is	be	VBZ
cord-356188-rwf78stz	78	7	expressed	express	VBN
cord-356188-rwf78stz	78	8	at	at	IN
cord-356188-rwf78stz	78	9	high	high	JJ
cord-356188-rwf78stz	78	10	levels	level	NNS
cord-356188-rwf78stz	78	11	on	on	IN
cord-356188-rwf78stz	78	12	the	the	DT
cord-356188-rwf78stz	78	13	surface	surface	NN
cord-356188-rwf78stz	78	14	of	of	IN
cord-356188-rwf78stz	78	15	influenza	influenza	NN
cord-356188-rwf78stz	78	16	-	-	HYPH
cord-356188-rwf78stz	78	17	infected	infect	VBN
cord-356188-rwf78stz	78	18	cells	cell	NNS
cord-356188-rwf78stz	78	19	and	and	CC
cord-356188-rwf78stz	78	20	has	have	VBZ
cord-356188-rwf78stz	78	21	a	a	DT
cord-356188-rwf78stz	78	22	conserved	conserve	VBN
cord-356188-rwf78stz	78	23	ectodomain	ectodomain	NN
cord-356188-rwf78stz	78	24	(	(	-LRB-
cord-356188-rwf78stz	78	25	M2e	M2e	VBG
cord-356188-rwf78stz	78	26	)	)	-RRB-
cord-356188-rwf78stz	78	27	that	that	WDT
cord-356188-rwf78stz	78	28	is	be	VBZ
cord-356188-rwf78stz	78	29	24	24	CD
cord-356188-rwf78stz	78	30	aa	aa	NN
cord-356188-rwf78stz	78	31	in	in	IN
cord-356188-rwf78stz	78	32	length	length	NN
cord-356188-rwf78stz	78	33	[	[	-LRB-
cord-356188-rwf78stz	78	34	65	65	CD
cord-356188-rwf78stz	78	35	]	]	-RRB-
cord-356188-rwf78stz	78	36	.	.	.
cord-356188-rwf78stz	79	1	Animal	animal	NN
cord-356188-rwf78stz	79	2	studies	study	NNS
cord-356188-rwf78stz	79	3	have	have	VBP
cord-356188-rwf78stz	79	4	demonstrated	demonstrate	VBN
cord-356188-rwf78stz	79	5	improved	improve	VBN
cord-356188-rwf78stz	79	6	viral	viral	JJ
cord-356188-rwf78stz	79	7	clearance	clearance	NN
cord-356188-rwf78stz	79	8	and	and	CC
cord-356188-rwf78stz	79	9	cross	cross	NN
cord-356188-rwf78stz	79	10	-	-	NN
cord-356188-rwf78stz	79	11	protection	protection	JJ
cord-356188-rwf78stz	79	12	upon	upon	IN
cord-356188-rwf78stz	79	13	lethal	lethal	JJ
cord-356188-rwf78stz	79	14	challenge	challenge	NN
cord-356188-rwf78stz	79	15	in	in	IN
cord-356188-rwf78stz	79	16	mice	mouse	NNS
cord-356188-rwf78stz	79	17	following	follow	VBG
cord-356188-rwf78stz	79	18	passive	passive	JJ
cord-356188-rwf78stz	79	19	M2	M2	NNP
cord-356188-rwf78stz	79	20	mAb	mab	NN
cord-356188-rwf78stz	79	21	transfer	transfer	NN
cord-356188-rwf78stz	79	22	or	or	CC
cord-356188-rwf78stz	79	23	M2-immunized	M2-immunized	NNP
cord-356188-rwf78stz	79	24	mice	mouse	NNS
cord-356188-rwf78stz	79	25	(	(	-LRB-
cord-356188-rwf78stz	79	26	reviewed	review	VBN
cord-356188-rwf78stz	79	27	in	in	IN
cord-356188-rwf78stz	79	28	ref	ref	NN
cord-356188-rwf78stz	79	29	.	.	.
cord-356188-rwf78stz	80	1	[	[	-LRB-
cord-356188-rwf78stz	80	2	66	66	CD
cord-356188-rwf78stz	80	3	]	]	-RRB-
cord-356188-rwf78stz	80	4	)	)	-RRB-
cord-356188-rwf78stz	80	5	.	.	.
cord-356188-rwf78stz	81	1	Phase	phase	NN
cord-356188-rwf78stz	81	2	I	-PRON-	PRP
cord-356188-rwf78stz	81	3	clinical	clinical	JJ
cord-356188-rwf78stz	81	4	safety	safety	NN
cord-356188-rwf78stz	81	5	trials	trial	NNS
cord-356188-rwf78stz	81	6	evaluating	evaluate	VBG
cord-356188-rwf78stz	81	7	VAX102	VAX102	NNP
cord-356188-rwf78stz	81	8	,	,	,
cord-356188-rwf78stz	81	9	manufactured	manufacture	VBN
cord-356188-rwf78stz	81	10	by	by	IN
cord-356188-rwf78stz	81	11	VaxInnate	VaxInnate	NNP
cord-356188-rwf78stz	81	12	,	,	,
cord-356188-rwf78stz	81	13	have	have	VBP
cord-356188-rwf78stz	81	14	reported	report	VBN
cord-356188-rwf78stz	81	15	increased	increase	VBN
cord-356188-rwf78stz	81	16	M2e	M2e	NNP
cord-356188-rwf78stz	81	17	antibody	antibody	NN
cord-356188-rwf78stz	81	18	responses	response	NNS
cord-356188-rwf78stz	81	19	[	[	-LRB-
cord-356188-rwf78stz	81	20	67	67	CD
cord-356188-rwf78stz	81	21	]	]	-RRB-
cord-356188-rwf78stz	81	22	.	.	.
cord-356188-rwf78stz	82	1	Creation	creation	NN
cord-356188-rwf78stz	82	2	of	of	IN
cord-356188-rwf78stz	82	3	a	a	DT
cord-356188-rwf78stz	82	4	universal	universal	JJ
cord-356188-rwf78stz	82	5	influenza	influenza	NN
cord-356188-rwf78stz	82	6	vaccine	vaccine	NN
cord-356188-rwf78stz	82	7	that	that	WDT
cord-356188-rwf78stz	82	8	targets	target	VBZ
cord-356188-rwf78stz	82	9	conserved	conserve	VBN
cord-356188-rwf78stz	82	10	regions	region	NNS
cord-356188-rwf78stz	82	11	of	of	IN
cord-356188-rwf78stz	82	12	the	the	DT
cord-356188-rwf78stz	82	13	HA	HA	NNP
cord-356188-rwf78stz	82	14	stem	stem	NN
cord-356188-rwf78stz	82	15	region	region	NN
cord-356188-rwf78stz	82	16	is	be	VBZ
cord-356188-rwf78stz	82	17	particularly	particularly	RB
cord-356188-rwf78stz	82	18	appealing	appealing	JJ
cord-356188-rwf78stz	82	19	,	,	,
cord-356188-rwf78stz	82	20	and	and	CC
cord-356188-rwf78stz	82	21	several	several	JJ
cord-356188-rwf78stz	82	22	groups	group	NNS
cord-356188-rwf78stz	82	23	have	have	VBP
cord-356188-rwf78stz	82	24	demonstrated	demonstrate	VBN
cord-356188-rwf78stz	82	25	encouraging	encouraging	JJ
cord-356188-rwf78stz	82	26	results	result	NNS
cord-356188-rwf78stz	82	27	using	use	VBG
cord-356188-rwf78stz	82	28	broadly	broadly	RB
cord-356188-rwf78stz	82	29	neutralizing	neutralize	VBG
cord-356188-rwf78stz	82	30	mAb	mAb	NNS
cord-356188-rwf78stz	82	31	to	to	IN
cord-356188-rwf78stz	82	32	regions	region	NNS
cord-356188-rwf78stz	82	33	of	of	IN
cord-356188-rwf78stz	82	34	HA	HA	NNP
cord-356188-rwf78stz	82	35	that	that	WDT
cord-356188-rwf78stz	82	36	are	be	VBP
cord-356188-rwf78stz	82	37	cross	cross	JJ
cord-356188-rwf78stz	82	38	-	-	JJ
cord-356188-rwf78stz	82	39	reactive	reactive	JJ
cord-356188-rwf78stz	82	40	between	between	IN
cord-356188-rwf78stz	82	41	Group	Group	NNP
cord-356188-rwf78stz	82	42	1	1	CD
cord-356188-rwf78stz	82	43	and	and	CC
cord-356188-rwf78stz	82	44	Group	Group	NNP
cord-356188-rwf78stz	82	45	2	2	CD
cord-356188-rwf78stz	82	46	influenza	influenza	NN
cord-356188-rwf78stz	82	47	strains	strain	NNS
cord-356188-rwf78stz	82	48	[	[	-LRB-
cord-356188-rwf78stz	82	49	68	68	CD
cord-356188-rwf78stz	82	50	-70	-70	NN
cord-356188-rwf78stz	82	51	]	]	-RRB-
cord-356188-rwf78stz	82	52	.	.	.
cord-356188-rwf78stz	83	1	Structural	structural	JJ
cord-356188-rwf78stz	83	2	analyses	analysis	NNS
cord-356188-rwf78stz	83	3	indicate	indicate	VBP
cord-356188-rwf78stz	83	4	that	that	IN
cord-356188-rwf78stz	83	5	these	these	DT
cord-356188-rwf78stz	83	6	antibodies	antibody	NNS
cord-356188-rwf78stz	83	7	bind	bind	VBP
cord-356188-rwf78stz	83	8	to	to	IN
cord-356188-rwf78stz	83	9	conserved	conserved	JJ
cord-356188-rwf78stz	83	10	pockets	pocket	NNS
cord-356188-rwf78stz	83	11	of	of	IN
cord-356188-rwf78stz	83	12	the	the	DT
cord-356188-rwf78stz	83	13	A	a	DT
cord-356188-rwf78stz	83	14	helix	helix	NN
cord-356188-rwf78stz	83	15	of	of	IN
cord-356188-rwf78stz	83	16	the	the	DT
cord-356188-rwf78stz	83	17	HA	HA	NNP
cord-356188-rwf78stz	83	18	stalk	stalk	NN
cord-356188-rwf78stz	83	19	,	,	,
cord-356188-rwf78stz	83	20	located	locate	VBN
cord-356188-rwf78stz	83	21	below	below	IN
cord-356188-rwf78stz	83	22	the	the	DT
cord-356188-rwf78stz	83	23	trimeric	trimeric	JJ
cord-356188-rwf78stz	83	24	head	head	NN
cord-356188-rwf78stz	83	25	region	region	NN
cord-356188-rwf78stz	83	26	[	[	-LRB-
cord-356188-rwf78stz	83	27	71	71	CD
cord-356188-rwf78stz	83	28	]	]	-RRB-
cord-356188-rwf78stz	83	29	[	[	-LRB-
cord-356188-rwf78stz	83	30	72	72	CD
cord-356188-rwf78stz	83	31	]	]	-RRB-
cord-356188-rwf78stz	83	32	[	[	-LRB-
cord-356188-rwf78stz	83	33	73	73	CD
cord-356188-rwf78stz	83	34	]	]	-RRB-
cord-356188-rwf78stz	83	35	.	.	.
cord-356188-rwf78stz	84	1	It	-PRON-	PRP
cord-356188-rwf78stz	84	2	is	be	VBZ
cord-356188-rwf78stz	84	3	therefore	therefore	RB
cord-356188-rwf78stz	84	4	within	within	IN
cord-356188-rwf78stz	84	5	the	the	DT
cord-356188-rwf78stz	84	6	realm	realm	NN
cord-356188-rwf78stz	84	7	of	of	IN
cord-356188-rwf78stz	84	8	possibility	possibility	NN
cord-356188-rwf78stz	84	9	to	to	TO
cord-356188-rwf78stz	84	10	focus	focus	VB
cord-356188-rwf78stz	84	11	immunization	immunization	NN
cord-356188-rwf78stz	84	12	strategies	strategy	NNS
cord-356188-rwf78stz	84	13	to	to	IN
cord-356188-rwf78stz	84	14	these	these	DT
cord-356188-rwf78stz	84	15	conserved	conserve	VBN
cord-356188-rwf78stz	84	16	regions	region	NNS
cord-356188-rwf78stz	84	17	in	in	IN
cord-356188-rwf78stz	84	18	the	the	DT
cord-356188-rwf78stz	84	19	HA	HA	NNP
cord-356188-rwf78stz	84	20	and	and	CC
cord-356188-rwf78stz	84	21	M2	m2	NN
cord-356188-rwf78stz	84	22	proteins	protein	NNS
cord-356188-rwf78stz	84	23	to	to	TO
cord-356188-rwf78stz	84	24	elicit	elicit	VB
cord-356188-rwf78stz	84	25	effective	effective	JJ
cord-356188-rwf78stz	84	26	antibody	antibody	NN
cord-356188-rwf78stz	84	27	,	,	,
cord-356188-rwf78stz	84	28	and	and	CC
cord-356188-rwf78stz	84	29	presumably	presumably	RB
cord-356188-rwf78stz	84	30	T	T	NNP
cord-356188-rwf78stz	84	31	cell	cell	NN
cord-356188-rwf78stz	84	32	,	,	,
cord-356188-rwf78stz	84	33	responses	response	NNS
cord-356188-rwf78stz	84	34	in	in	IN
cord-356188-rwf78stz	84	35	the	the	DT
cord-356188-rwf78stz	84	36	case	case	NN
cord-356188-rwf78stz	84	37	of	of	IN
cord-356188-rwf78stz	84	38	emergent	emergent	JJ
cord-356188-rwf78stz	84	39	influenza	influenza	NN
cord-356188-rwf78stz	84	40	viruses	virus	NNS
cord-356188-rwf78stz	84	41	.	.	.
cord-356188-rwf78stz	85	1	Still	still	RB
cord-356188-rwf78stz	85	2	,	,	,
cord-356188-rwf78stz	85	3	it	-PRON-	PRP
cord-356188-rwf78stz	85	4	remains	remain	VBZ
cord-356188-rwf78stz	85	5	a	a	DT
cord-356188-rwf78stz	85	6	mystery	mystery	NN
cord-356188-rwf78stz	85	7	as	as	IN
cord-356188-rwf78stz	85	8	to	to	IN
cord-356188-rwf78stz	85	9	why	why	WRB
cord-356188-rwf78stz	85	10	these	these	DT
cord-356188-rwf78stz	85	11	conserved	conserve	VBN
cord-356188-rwf78stz	85	12	epitopes	epitope	NNS
cord-356188-rwf78stz	85	13	have	have	VBP
cord-356188-rwf78stz	85	14	not	not	RB
cord-356188-rwf78stz	85	15	generated	generate	VBN
cord-356188-rwf78stz	85	16	a	a	DT
cord-356188-rwf78stz	85	17	high	high	JJ
cord-356188-rwf78stz	85	18	level	level	NN
cord-356188-rwf78stz	85	19	of	of	IN
cord-356188-rwf78stz	85	20	cross	cross	NN
cord-356188-rwf78stz	85	21	-	-	NN
cord-356188-rwf78stz	85	22	protection	protection	NN
cord-356188-rwf78stz	85	23	in	in	IN
cord-356188-rwf78stz	85	24	populations	population	NNS
cord-356188-rwf78stz	85	25	repeatedly	repeatedly	RB
cord-356188-rwf78stz	85	26	immunized	immunize	VBD
cord-356188-rwf78stz	85	27	or	or	CC
cord-356188-rwf78stz	85	28	infected	infect	VBN
cord-356188-rwf78stz	85	29	with	with	IN
cord-356188-rwf78stz	85	30	diverse	diverse	JJ
cord-356188-rwf78stz	85	31	viral	viral	JJ
cord-356188-rwf78stz	85	32	strains	strain	NNS
cord-356188-rwf78stz	85	33	.	.	.
cord-356188-rwf78stz	86	1	Factors	factor	NNS
cord-356188-rwf78stz	86	2	that	that	WDT
cord-356188-rwf78stz	86	3	limit	limit	VBP
cord-356188-rwf78stz	86	4	influenza	influenza	NN
cord-356188-rwf78stz	86	5	vaccine	vaccine	NN
cord-356188-rwf78stz	86	6	efficacy	efficacy	NN
cord-356188-rwf78stz	86	7	in	in	IN
cord-356188-rwf78stz	86	8	humans	human	NNS
cord-356188-rwf78stz	86	9	include	include	VBP
cord-356188-rwf78stz	86	10	age	age	NN
cord-356188-rwf78stz	86	11	,	,	,
cord-356188-rwf78stz	86	12	immunocompetence	immunocompetence	NN
cord-356188-rwf78stz	86	13	,	,	,
cord-356188-rwf78stz	86	14	and	and	CC
cord-356188-rwf78stz	86	15	pre	pre	JJ
cord-356188-rwf78stz	86	16	-	-	JJ
cord-356188-rwf78stz	86	17	existing	existing	JJ
cord-356188-rwf78stz	86	18	antibody	antibody	NN
cord-356188-rwf78stz	86	19	levels	level	NNS
cord-356188-rwf78stz	86	20	from	from	IN
cord-356188-rwf78stz	86	21	previous	previous	JJ
cord-356188-rwf78stz	86	22	infections	infection	NNS
cord-356188-rwf78stz	86	23	or	or	CC
cord-356188-rwf78stz	86	24	immunizations	immunization	NNS
cord-356188-rwf78stz	86	25	.	.	.
cord-356188-rwf78stz	87	1	Whereas	whereas	IN
cord-356188-rwf78stz	87	2	key	key	JJ
cord-356188-rwf78stz	87	3	lessons	lesson	NNS
cord-356188-rwf78stz	87	4	have	have	VBP
cord-356188-rwf78stz	87	5	been	be	VBN
cord-356188-rwf78stz	87	6	learned	learn	VBN
cord-356188-rwf78stz	87	7	using	use	VBG
cord-356188-rwf78stz	87	8	animal	animal	NN
cord-356188-rwf78stz	87	9	models	model	NNS
cord-356188-rwf78stz	87	10	of	of	IN
cord-356188-rwf78stz	87	11	influenza	influenza	NN
cord-356188-rwf78stz	87	12	infection	infection	NN
cord-356188-rwf78stz	87	13	,	,	,
cord-356188-rwf78stz	87	14	studies	study	NNS
cord-356188-rwf78stz	87	15	done	do	VBN
cord-356188-rwf78stz	87	16	using	use	VBG
cord-356188-rwf78stz	87	17	human	human	JJ
cord-356188-rwf78stz	87	18	participants	participant	NNS
cord-356188-rwf78stz	87	19	are	be	VBP
cord-356188-rwf78stz	87	20	invaluable	invaluable	JJ
cord-356188-rwf78stz	87	21	for	for	IN
cord-356188-rwf78stz	87	22	describing	describe	VBG
cord-356188-rwf78stz	87	23	the	the	DT
cord-356188-rwf78stz	87	24	unique	unique	JJ
cord-356188-rwf78stz	87	25	and	and	CC
cord-356188-rwf78stz	87	26	often	often	RB
cord-356188-rwf78stz	87	27	complex	complex	JJ
cord-356188-rwf78stz	87	28	characteristics	characteristic	NNS
cord-356188-rwf78stz	87	29	of	of	IN
cord-356188-rwf78stz	87	30	the	the	DT
cord-356188-rwf78stz	87	31	human	human	JJ
cord-356188-rwf78stz	87	32	immune	immune	JJ
cord-356188-rwf78stz	87	33	response	response	NN
cord-356188-rwf78stz	87	34	to	to	IN
cord-356188-rwf78stz	87	35	infection	infection	NN
cord-356188-rwf78stz	87	36	and	and	CC
cord-356188-rwf78stz	87	37	immunization	immunization	NN
cord-356188-rwf78stz	87	38	.	.	.
cord-356188-rwf78stz	88	1	Here	here	RB
cord-356188-rwf78stz	88	2	,	,	,
cord-356188-rwf78stz	88	3	we	-PRON-	PRP
cord-356188-rwf78stz	88	4	describe	describe	VBP
cord-356188-rwf78stz	88	5	central	central	JJ
cord-356188-rwf78stz	88	6	findings	finding	NNS
cord-356188-rwf78stz	88	7	obtained	obtain	VBN
cord-356188-rwf78stz	88	8	from	from	IN
cord-356188-rwf78stz	88	9	human	human	JJ
cord-356188-rwf78stz	88	10	influenza	influenza	NN
cord-356188-rwf78stz	88	11	challenge	challenge	NN
cord-356188-rwf78stz	88	12	studies	study	NNS
cord-356188-rwf78stz	88	13	,	,	,
cord-356188-rwf78stz	88	14	natural	natural	JJ
cord-356188-rwf78stz	88	15	infections	infection	NNS
cord-356188-rwf78stz	88	16	,	,	,
cord-356188-rwf78stz	88	17	and	and	CC
cord-356188-rwf78stz	88	18	ex	ex	FW
cord-356188-rwf78stz	88	19	vivo	vivo	NN
cord-356188-rwf78stz	88	20	characterization	characterization	NN
cord-356188-rwf78stz	88	21	of	of	IN
cord-356188-rwf78stz	88	22	human	human	JJ
cord-356188-rwf78stz	88	23	immune	immune	JJ
cord-356188-rwf78stz	88	24	cells	cell	NNS
cord-356188-rwf78stz	88	25	(	(	-LRB-
cord-356188-rwf78stz	88	26	Table	table	NN
cord-356188-rwf78stz	88	27	1	1	CD
cord-356188-rwf78stz	88	28	)	)	-RRB-
cord-356188-rwf78stz	88	29	.	.	.
cord-356188-rwf78stz	89	1	Figure	figure	NN
cord-356188-rwf78stz	89	2	1	1	CD
cord-356188-rwf78stz	89	3	indicates	indicate	VBZ
cord-356188-rwf78stz	89	4	where	where	WRB
cord-356188-rwf78stz	89	5	questions	question	NNS
cord-356188-rwf78stz	89	6	remain	remain	VBP
cord-356188-rwf78stz	89	7	for	for	IN
cord-356188-rwf78stz	89	8	the	the	DT
cord-356188-rwf78stz	89	9	human	human	JJ
cord-356188-rwf78stz	89	10	immune	immune	JJ
cord-356188-rwf78stz	89	11	response	response	NN
cord-356188-rwf78stz	89	12	to	to	IN
cord-356188-rwf78stz	89	13	infection	infection	NN
cord-356188-rwf78stz	89	14	.	.	.
cord-356188-rwf78stz	90	1	Effective	effective	JJ
cord-356188-rwf78stz	90	2	control	control	NN
cord-356188-rwf78stz	90	3	and	and	CC
cord-356188-rwf78stz	90	4	clearance	clearance	NN
cord-356188-rwf78stz	90	5	of	of	IN
cord-356188-rwf78stz	90	6	influenza	influenza	NN
cord-356188-rwf78stz	90	7	infection	infection	NN
cord-356188-rwf78stz	90	8	can	can	MD
cord-356188-rwf78stz	90	9	involve	involve	VB
cord-356188-rwf78stz	90	10	most	most	JJS
cord-356188-rwf78stz	90	11	components	component	NNS
cord-356188-rwf78stz	90	12	of	of	IN
cord-356188-rwf78stz	90	13	the	the	DT
cord-356188-rwf78stz	90	14	innate	innate	JJ
cord-356188-rwf78stz	90	15	and	and	CC
cord-356188-rwf78stz	90	16	adaptive	adaptive	JJ
cord-356188-rwf78stz	90	17	immune	immune	JJ
cord-356188-rwf78stz	90	18	responses	response	NNS
cord-356188-rwf78stz	90	19	.	.	.
cord-356188-rwf78stz	91	1	In	in	IN
cord-356188-rwf78stz	91	2	mammals	mammal	NNS
cord-356188-rwf78stz	91	3	,	,	,
cord-356188-rwf78stz	91	4	the	the	DT
cord-356188-rwf78stz	91	5	cellular	cellular	JJ
cord-356188-rwf78stz	91	6	innate	innate	JJ
cord-356188-rwf78stz	91	7	immune	immune	JJ
cord-356188-rwf78stz	91	8	system	system	NN
cord-356188-rwf78stz	91	9	acts	act	VBZ
cord-356188-rwf78stz	91	10	as	as	IN
cord-356188-rwf78stz	91	11	a	a	DT
cord-356188-rwf78stz	91	12	first	first	JJ
cord-356188-rwf78stz	91	13	-	-	HYPH
cord-356188-rwf78stz	91	14	line	line	NN
cord-356188-rwf78stz	91	15	defense	defense	NN
cord-356188-rwf78stz	91	16	consisting	consist	VBG
cord-356188-rwf78stz	91	17	of	of	IN
cord-356188-rwf78stz	91	18	multipotent	multipotent	JJ
cord-356188-rwf78stz	91	19	hematopoietic	hematopoietic	JJ
cord-356188-rwf78stz	91	20	stem	stem	NN
cord-356188-rwf78stz	91	21	cells	cell	NNS
cord-356188-rwf78stz	91	22	that	that	WDT
cord-356188-rwf78stz	91	23	differentiate	differentiate	VBP
cord-356188-rwf78stz	91	24	into	into	IN
cord-356188-rwf78stz	91	25	NK	NK	NNP
cord-356188-rwf78stz	91	26	cells	cell	NNS
cord-356188-rwf78stz	91	27	,	,	,
cord-356188-rwf78stz	91	28	mast	mast	NN
cord-356188-rwf78stz	91	29	cells	cell	NNS
cord-356188-rwf78stz	91	30	,	,	,
cord-356188-rwf78stz	91	31	eosinophils	eosinophil	NNS
cord-356188-rwf78stz	91	32	,	,	,
cord-356188-rwf78stz	91	33	and	and	CC
cord-356188-rwf78stz	91	34	basophils	basophil	NNS
cord-356188-rwf78stz	91	35	,	,	,
cord-356188-rwf78stz	91	36	as	as	RB
cord-356188-rwf78stz	91	37	well	well	RB
cord-356188-rwf78stz	91	38	as	as	IN
cord-356188-rwf78stz	91	39	macrophages	macrophage	NNS
cord-356188-rwf78stz	91	40	,	,	,
cord-356188-rwf78stz	91	41	neutrophils	neutrophil	NNS
cord-356188-rwf78stz	91	42	,	,	,
cord-356188-rwf78stz	91	43	and	and	CC
cord-356188-rwf78stz	91	44	DCs	DCs	NNP
cord-356188-rwf78stz	91	45	,	,	,
cord-356188-rwf78stz	91	46	collectively	collectively	RB
cord-356188-rwf78stz	91	47	known	know	VBN
cord-356188-rwf78stz	91	48	as	as	IN
cord-356188-rwf78stz	91	49	phagocytic	phagocytic	JJ
cord-356188-rwf78stz	91	50	cells	cell	NNS
cord-356188-rwf78stz	91	51	.	.	.
cord-356188-rwf78stz	92	1	Phagocytes	phagocyte	NNS
cord-356188-rwf78stz	92	2	function	function	VBP
cord-356188-rwf78stz	92	3	as	as	IN
cord-356188-rwf78stz	92	4	APCs	apc	NNS
cord-356188-rwf78stz	92	5	,	,	,
cord-356188-rwf78stz	92	6	engulfing	engulf	VBG
cord-356188-rwf78stz	92	7	and	and	CC
cord-356188-rwf78stz	92	8	digesting	digest	VBG
cord-356188-rwf78stz	92	9	opsonized	opsonize	VBN
cord-356188-rwf78stz	92	10	pathogens	pathogen	NNS
cord-356188-rwf78stz	92	11	and	and	CC
cord-356188-rwf78stz	92	12	apoptotic	apoptotic	JJ
cord-356188-rwf78stz	92	13	cells	cell	NNS
cord-356188-rwf78stz	92	14	.	.	.
cord-356188-rwf78stz	93	1	These	these	DT
cord-356188-rwf78stz	93	2	cells	cell	NNS
cord-356188-rwf78stz	93	3	essentially	essentially	RB
cord-356188-rwf78stz	93	4	act	act	VBP
cord-356188-rwf78stz	93	5	as	as	IN
cord-356188-rwf78stz	93	6	scavengers	scavenger	NNS
cord-356188-rwf78stz	93	7	to	to	IN
cord-356188-rwf78stz	93	8	uptake	uptake	NN
cord-356188-rwf78stz	93	9	toxic	toxic	JJ
cord-356188-rwf78stz	93	10	metabolic	metabolic	JJ
cord-356188-rwf78stz	93	11	byproducts	byproduct	NNS
cord-356188-rwf78stz	93	12	and	and	CC
cord-356188-rwf78stz	93	13	produce	produce	VBP
cord-356188-rwf78stz	93	14	myriad	myriad	JJ
cord-356188-rwf78stz	93	15	inflammatory	inflammatory	JJ
cord-356188-rwf78stz	93	16	mediators	mediator	NNS
cord-356188-rwf78stz	93	17	,	,	,
cord-356188-rwf78stz	93	18	which	which	WDT
cord-356188-rwf78stz	93	19	ideally	ideally	RB
cord-356188-rwf78stz	93	20	,	,	,
cord-356188-rwf78stz	93	21	result	result	VB
cord-356188-rwf78stz	93	22	in	in	IN
cord-356188-rwf78stz	93	23	the	the	DT
cord-356188-rwf78stz	93	24	killing	killing	NN
cord-356188-rwf78stz	93	25	of	of	IN
cord-356188-rwf78stz	93	26	viruses	virus	NNS
cord-356188-rwf78stz	93	27	,	,	,
cord-356188-rwf78stz	93	28	bacteria	bacteria	NNS
cord-356188-rwf78stz	93	29	,	,	,
cord-356188-rwf78stz	93	30	and	and	CC
cord-356188-rwf78stz	93	31	parasites	parasite	NNS
cord-356188-rwf78stz	93	32	.	.	.
cord-356188-rwf78stz	94	1	However	however	RB
cord-356188-rwf78stz	94	2	,	,	,
cord-356188-rwf78stz	94	3	abundant	abundant	JJ
cord-356188-rwf78stz	94	4	inflammation	inflammation	NN
cord-356188-rwf78stz	94	5	often	often	RB
cord-356188-rwf78stz	94	6	has	have	VBZ
cord-356188-rwf78stz	94	7	a	a	DT
cord-356188-rwf78stz	94	8	role	role	NN
cord-356188-rwf78stz	94	9	in	in	IN
cord-356188-rwf78stz	94	10	creating	create	VBG
cord-356188-rwf78stz	94	11	immunopathology	immunopathology	NN
cord-356188-rwf78stz	94	12	and	and	CC
cord-356188-rwf78stz	94	13	can	can	MD
cord-356188-rwf78stz	94	14	contribute	contribute	VB
cord-356188-rwf78stz	94	15	to	to	IN
cord-356188-rwf78stz	94	16	diverse	diverse	JJ
cord-356188-rwf78stz	94	17	inflammatory	inflammatory	JJ
cord-356188-rwf78stz	94	18	diseases	disease	NNS
cord-356188-rwf78stz	94	19	,	,	,
cord-356188-rwf78stz	94	20	including	include	VBG
cord-356188-rwf78stz	94	21	asthma	asthma	NN
cord-356188-rwf78stz	94	22	[	[	-LRB-
cord-356188-rwf78stz	94	23	123	123	CD
cord-356188-rwf78stz	94	24	]	]	-RRB-
cord-356188-rwf78stz	94	25	[	[	-LRB-
cord-356188-rwf78stz	94	26	124	124	CD
cord-356188-rwf78stz	94	27	]	]	-RRB-
cord-356188-rwf78stz	94	28	[	[	-LRB-
cord-356188-rwf78stz	94	29	125	125	CD
cord-356188-rwf78stz	94	30	]	]	-RRB-
cord-356188-rwf78stz	94	31	.	.	.
cord-356188-rwf78stz	95	1	In	in	IN
cord-356188-rwf78stz	95	2	the	the	DT
cord-356188-rwf78stz	95	3	absence	absence	NN
cord-356188-rwf78stz	95	4	of	of	IN
cord-356188-rwf78stz	95	5	protective	protective	JJ
cord-356188-rwf78stz	95	6	immune	immune	JJ
cord-356188-rwf78stz	95	7	memory	memory	NN
cord-356188-rwf78stz	95	8	,	,	,
cord-356188-rwf78stz	95	9	the	the	DT
cord-356188-rwf78stz	95	10	innate	innate	JJ
cord-356188-rwf78stz	95	11	response	response	NN
cord-356188-rwf78stz	95	12	limits	limit	VBZ
cord-356188-rwf78stz	95	13	initial	initial	JJ
cord-356188-rwf78stz	95	14	viral	viral	JJ
cord-356188-rwf78stz	95	15	replication	replication	NN
cord-356188-rwf78stz	95	16	,	,	,
cord-356188-rwf78stz	95	17	while	while	IN
cord-356188-rwf78stz	95	18	the	the	DT
cord-356188-rwf78stz	95	19	adaptive	adaptive	JJ
cord-356188-rwf78stz	95	20	immune	immune	JJ
cord-356188-rwf78stz	95	21	response	response	NN
cord-356188-rwf78stz	95	22	develops	develop	VBZ
cord-356188-rwf78stz	95	23	.	.	.
cord-356188-rwf78stz	96	1	Influenza	influenza	NN
cord-356188-rwf78stz	96	2	primarily	primarily	RB
cord-356188-rwf78stz	96	3	infects	infect	VBZ
cord-356188-rwf78stz	96	4	epithelial	epithelial	JJ
cord-356188-rwf78stz	96	5	cells	cell	NNS
cord-356188-rwf78stz	96	6	lining	line	VBG
cord-356188-rwf78stz	96	7	the	the	DT
cord-356188-rwf78stz	96	8	respiratory	respiratory	JJ
cord-356188-rwf78stz	96	9	tract	tract	NN
cord-356188-rwf78stz	96	10	but	but	CC
cord-356188-rwf78stz	96	11	can	can	MD
cord-356188-rwf78stz	96	12	infect	infect	VB
cord-356188-rwf78stz	96	13	directly	directly	RB
cord-356188-rwf78stz	96	14	or	or	CC
cord-356188-rwf78stz	96	15	be	be	VB
cord-356188-rwf78stz	96	16	phagoctyosed	phagoctyose	VBN
cord-356188-rwf78stz	96	17	by	by	IN
cord-356188-rwf78stz	96	18	"	"	``
cord-356188-rwf78stz	96	19	professional	professional	JJ
cord-356188-rwf78stz	96	20	"	"	''
cord-356188-rwf78stz	96	21	innate	innate	JJ
cord-356188-rwf78stz	96	22	immune	immune	JJ
cord-356188-rwf78stz	96	23	cells	cell	NNS
cord-356188-rwf78stz	96	24	,	,	,
cord-356188-rwf78stz	96	25	DCs	dc	NNS
cord-356188-rwf78stz	96	26	,	,	,
cord-356188-rwf78stz	96	27	and	and	CC
cord-356188-rwf78stz	96	28	macrophages	macrophage	NNS
cord-356188-rwf78stz	96	29	,	,	,
cord-356188-rwf78stz	96	30	which	which	WDT
cord-356188-rwf78stz	96	31	mature	mature	VBP
cord-356188-rwf78stz	96	32	in	in	IN
cord-356188-rwf78stz	96	33	response	response	NN
cord-356188-rwf78stz	96	34	to	to	IN
cord-356188-rwf78stz	96	35	viral	viral	JJ
cord-356188-rwf78stz	96	36	stimuli	stimulus	NNS
cord-356188-rwf78stz	96	37	or	or	CC
cord-356188-rwf78stz	96	38	signals	signal	NNS
cord-356188-rwf78stz	96	39	from	from	IN
cord-356188-rwf78stz	96	40	other	other	JJ
cord-356188-rwf78stz	96	41	infected	infected	JJ
cord-356188-rwf78stz	96	42	cells	cell	NNS
cord-356188-rwf78stz	96	43	.	.	.
cord-356188-rwf78stz	97	1	After	after	IN
cord-356188-rwf78stz	97	2	activation	activation	NN
cord-356188-rwf78stz	97	3	,	,	,
cord-356188-rwf78stz	97	4	mature	mature	JJ
cord-356188-rwf78stz	97	5	DCs	dc	NNS
cord-356188-rwf78stz	97	6	migrate	migrate	VBP
cord-356188-rwf78stz	97	7	to	to	IN
cord-356188-rwf78stz	97	8	draining	drain	VBG
cord-356188-rwf78stz	97	9	LNs	ln	NNS
cord-356188-rwf78stz	97	10	,	,	,
cord-356188-rwf78stz	97	11	where	where	WRB
cord-356188-rwf78stz	97	12	they	-PRON-	PRP
cord-356188-rwf78stz	97	13	have	have	VBP
cord-356188-rwf78stz	97	14	a	a	DT
cord-356188-rwf78stz	97	15	major	major	JJ
cord-356188-rwf78stz	97	16	role	role	NN
cord-356188-rwf78stz	97	17	in	in	IN
cord-356188-rwf78stz	97	18	antigen	antigen	NN
cord-356188-rwf78stz	97	19	presentation	presentation	NN
cord-356188-rwf78stz	97	20	to	to	IN
cord-356188-rwf78stz	97	21	naïve	naïve	JJ
cord-356188-rwf78stz	97	22	T	T	NNP
cord-356188-rwf78stz	97	23	cells	cell	NNS
cord-356188-rwf78stz	97	24	.	.	.
cord-356188-rwf78stz	98	1	Influenza	influenza	NN
cord-356188-rwf78stz	98	2	infection	infection	NN
cord-356188-rwf78stz	98	3	of	of	IN
cord-356188-rwf78stz	98	4	human	human	JJ
cord-356188-rwf78stz	98	5	monocyte	monocyte	NNP
cord-356188-rwf78stz	98	6	-	-	HYPH
cord-356188-rwf78stz	98	7	derived	derive	VBN
cord-356188-rwf78stz	98	8	DCs	dc	NNS
cord-356188-rwf78stz	98	9	can	can	MD
cord-356188-rwf78stz	98	10	result	result	VB
cord-356188-rwf78stz	98	11	in	in	IN
cord-356188-rwf78stz	98	12	decreased	decrease	VBN
cord-356188-rwf78stz	98	13	DC	DC	NNP
cord-356188-rwf78stz	98	14	maturation	maturation	NN
cord-356188-rwf78stz	98	15	from	from	IN
cord-356188-rwf78stz	98	16	NS1	ns1	NN
cord-356188-rwf78stz	98	17	suppression	suppression	NN
cord-356188-rwf78stz	98	18	of	of	IN
cord-356188-rwf78stz	98	19	type	type	NN
cord-356188-rwf78stz	99	1	I	-PRON-	PRP
cord-356188-rwf78stz	99	2	IFN	IFN	NNP
cord-356188-rwf78stz	99	3	production	production	NN
cord-356188-rwf78stz	99	4	[	[	-LRB-
cord-356188-rwf78stz	99	5	126	126	CD
cord-356188-rwf78stz	99	6	]	]	-RRB-
cord-356188-rwf78stz	99	7	.	.	.
cord-356188-rwf78stz	100	1	Seasonal	Seasonal	NNP
cord-356188-rwf78stz	100	2	H1N1	H1N1	NNP
cord-356188-rwf78stz	100	3	viruses	virus	NNS
cord-356188-rwf78stz	100	4	,	,	,
cord-356188-rwf78stz	100	5	including	include	VBG
cord-356188-rwf78stz	100	6	A(H1N1)pdm09	A(H1N1)pdm09	NNP
cord-356188-rwf78stz	100	7	,	,	,
cord-356188-rwf78stz	100	8	elicit	elicit	VB
cord-356188-rwf78stz	100	9	weak	weak	JJ
cord-356188-rwf78stz	100	10	,	,	,
cord-356188-rwf78stz	100	11	proinflammatory	proinflammatory	JJ
cord-356188-rwf78stz	100	12	cytokine	cytokine	NN
cord-356188-rwf78stz	100	13	gene	gene	NN
cord-356188-rwf78stz	100	14	expression	expression	NN
cord-356188-rwf78stz	100	15	in	in	IN
cord-356188-rwf78stz	100	16	human	human	JJ
cord-356188-rwf78stz	100	17	DCs	dc	NNS
cord-356188-rwf78stz	100	18	[	[	-LRB-
cord-356188-rwf78stz	100	19	127	127	CD
cord-356188-rwf78stz	100	20	]	]	-RRB-
cord-356188-rwf78stz	100	21	.	.	.
cord-356188-rwf78stz	101	1	We	-PRON-	PRP
cord-356188-rwf78stz	101	2	know	know	VBP
cord-356188-rwf78stz	101	3	from	from	IN
cord-356188-rwf78stz	101	4	murine	murine	JJ
cord-356188-rwf78stz	101	5	models	model	NNS
cord-356188-rwf78stz	101	6	that	that	WDT
cord-356188-rwf78stz	101	7	influenza	influenza	NN
cord-356188-rwf78stz	101	8	contains	contain	VBZ
cord-356188-rwf78stz	101	9	ligands	ligand	NNS
cord-356188-rwf78stz	101	10	that	that	WDT
cord-356188-rwf78stz	101	11	activate	activate	VBP
cord-356188-rwf78stz	101	12	several	several	JJ
cord-356188-rwf78stz	101	13	PRR	PRR	NNP
cord-356188-rwf78stz	101	14	signaling	signal	VBG
cord-356188-rwf78stz	101	15	pathways	pathway	NNS
cord-356188-rwf78stz	101	16	,	,	,
cord-356188-rwf78stz	101	17	including	include	VBG
cord-356188-rwf78stz	101	18	TLR3	TLR3	NNP
cord-356188-rwf78stz	101	19	and	and	CC
cord-356188-rwf78stz	101	20	retinoic	retinoic	JJ
cord-356188-rwf78stz	101	21	acid	acid	NN
cord-356188-rwf78stz	101	22	-	-	HYPH
cord-356188-rwf78stz	101	23	inducible	inducible	JJ
cord-356188-rwf78stz	101	24	gene	gene	NN
cord-356188-rwf78stz	101	25	I	-PRON-	PRP
cord-356188-rwf78stz	102	1	(	(	-LRB-
cord-356188-rwf78stz	102	2	RIG	rig	NN
cord-356188-rwf78stz	102	3	-	-	HYPH
cord-356188-rwf78stz	102	4	I	I	NNP
cord-356188-rwf78stz	102	5	)	)	-RRB-
cord-356188-rwf78stz	102	6	,	,	,
cord-356188-rwf78stz	102	7	which	which	WDT
cord-356188-rwf78stz	102	8	recognize	recognize	VBP
cord-356188-rwf78stz	102	9	dsRNA	dsrna	NN
cord-356188-rwf78stz	102	10	,	,	,
cord-356188-rwf78stz	102	11	and	and	CC
cord-356188-rwf78stz	102	12	TLR7	TLR7	NNP
cord-356188-rwf78stz	102	13	,	,	,
cord-356188-rwf78stz	102	14	which	which	WDT
cord-356188-rwf78stz	102	15	recognizes	recognize	VBZ
cord-356188-rwf78stz	102	16	ssRNA	ssRNA	VBG
cord-356188-rwf78stz	102	17	[	[	-LRB-
cord-356188-rwf78stz	102	18	128	128	CD
cord-356188-rwf78stz	102	19	-130	-130	NN
cord-356188-rwf78stz	102	20	]	]	-RRB-
cord-356188-rwf78stz	102	21	.	.	.
cord-356188-rwf78stz	103	1	Type	type	NN
cord-356188-rwf78stz	103	2	I	-PRON-	PRP
cord-356188-rwf78stz	103	3	(	(	-LRB-
cord-356188-rwf78stz	103	4	IFN-	IFN-	NNP
cord-356188-rwf78stz	103	5	␣	␣	NNP
cord-356188-rwf78stz	103	6	/	/	SYM
cord-356188-rwf78stz	103	7	␤	␤	NNP
cord-356188-rwf78stz	103	8	)	)	-RRB-
cord-356188-rwf78stz	103	9	and	and	CC
cord-356188-rwf78stz	103	10	type	type	NN
cord-356188-rwf78stz	103	11	III	iii	CD
cord-356188-rwf78stz	104	1	(	(	-LRB-
cord-356188-rwf78stz	104	2	IFN-1	IFN-1	NNP
cord-356188-rwf78stz	104	3	-	-	HYPH
cord-356188-rwf78stz	104	4	3	3	CD
cord-356188-rwf78stz	104	5	)	)	-RRB-
cord-356188-rwf78stz	104	6	IFNs	ifn	NNS
cord-356188-rwf78stz	104	7	mediate	mediate	VB
cord-356188-rwf78stz	104	8	expression	expression	NN
cord-356188-rwf78stz	104	9	of	of	IN
cord-356188-rwf78stz	104	10	more	more	JJR
cord-356188-rwf78stz	104	11	than	than	IN
cord-356188-rwf78stz	104	12	300	300	CD
cord-356188-rwf78stz	104	13	ISGs	isg	NNS
cord-356188-rwf78stz	104	14	via	via	IN
cord-356188-rwf78stz	104	15	the	the	DT
cord-356188-rwf78stz	104	16	JAK	JAK	NNP
cord-356188-rwf78stz	104	17	/	/	SYM
cord-356188-rwf78stz	104	18	STAT	stat	NN
cord-356188-rwf78stz	104	19	pathway	pathway	NN
cord-356188-rwf78stz	104	20	and	and	CC
cord-356188-rwf78stz	104	21	are	be	VBP
cord-356188-rwf78stz	104	22	important	important	JJ
cord-356188-rwf78stz	104	23	in	in	IN
cord-356188-rwf78stz	104	24	the	the	DT
cord-356188-rwf78stz	104	25	induction	induction	NN
cord-356188-rwf78stz	104	26	of	of	IN
cord-356188-rwf78stz	104	27	antiviral	antiviral	JJ
cord-356188-rwf78stz	104	28	responses	response	NNS
cord-356188-rwf78stz	104	29	against	against	IN
cord-356188-rwf78stz	104	30	influenza	influenza	NN
cord-356188-rwf78stz	104	31	viruses	virus	NNS
cord-356188-rwf78stz	104	32	[	[	-LRB-
cord-356188-rwf78stz	104	33	131	131	CD
cord-356188-rwf78stz	104	34	]	]	-RRB-
cord-356188-rwf78stz	104	35	.	.	.
cord-356188-rwf78stz	105	1	Stimulation	stimulation	NN
cord-356188-rwf78stz	105	2	of	of	IN
cord-356188-rwf78stz	105	3	these	these	DT
cord-356188-rwf78stz	105	4	pathways	pathway	NNS
cord-356188-rwf78stz	105	5	in	in	IN
cord-356188-rwf78stz	105	6	DCs	DCs	NNP
cord-356188-rwf78stz	105	7	and	and	CC
cord-356188-rwf78stz	105	8	macrophages	macrophage	NNS
cord-356188-rwf78stz	105	9	leads	lead	VBZ
cord-356188-rwf78stz	105	10	to	to	IN
cord-356188-rwf78stz	105	11	the	the	DT
cord-356188-rwf78stz	105	12	induction	induction	NN
cord-356188-rwf78stz	105	13	of	of	IN
cord-356188-rwf78stz	105	14	a	a	DT
cord-356188-rwf78stz	105	15	potent	potent	JJ
cord-356188-rwf78stz	105	16	antiviral	antiviral	JJ
cord-356188-rwf78stz	105	17	response	response	NN
cord-356188-rwf78stz	105	18	,	,	,
cord-356188-rwf78stz	105	19	including	include	VBG
cord-356188-rwf78stz	105	20	production	production	NN
cord-356188-rwf78stz	105	21	of	of	IN
cord-356188-rwf78stz	105	22	proinflammatory	proinflammatory	JJ
cord-356188-rwf78stz	105	23	cytokines	cytokine	NNS
cord-356188-rwf78stz	106	1	IL-6	IL-6	NNP
cord-356188-rwf78stz	106	2	and	and	CC
cord-356188-rwf78stz	106	3	IFN-	IFN-	NNP
cord-356188-rwf78stz	106	4	␣	␣	NFP
cord-356188-rwf78stz	106	5	within	within	IN
cord-356188-rwf78stz	106	6	the	the	DT
cord-356188-rwf78stz	106	7	respiratory	respiratory	JJ
cord-356188-rwf78stz	106	8	tract	tract	NN
cord-356188-rwf78stz	106	9	by	by	IN
cord-356188-rwf78stz	106	10	Day	day	NN
cord-356188-rwf78stz	106	11	2	2	CD
cord-356188-rwf78stz	106	12	following	follow	VBG
cord-356188-rwf78stz	106	13	infection	infection	NN
cord-356188-rwf78stz	106	14	,	,	,
cord-356188-rwf78stz	106	15	paralleling	parallel	VBG
cord-356188-rwf78stz	106	16	the	the	DT
cord-356188-rwf78stz	106	17	peak	peak	NN
cord-356188-rwf78stz	106	18	of	of	IN
cord-356188-rwf78stz	106	19	viral	viral	JJ
cord-356188-rwf78stz	106	20	replication	replication	NN
cord-356188-rwf78stz	106	21	,	,	,
cord-356188-rwf78stz	106	22	mucus	mucus	NN
cord-356188-rwf78stz	106	23	production	production	NN
cord-356188-rwf78stz	106	24	,	,	,
cord-356188-rwf78stz	106	25	and	and	CC
cord-356188-rwf78stz	106	26	disease	disease	NN
cord-356188-rwf78stz	106	27	symptoms	symptom	NNS
cord-356188-rwf78stz	106	28	.	.	.
cord-356188-rwf78stz	107	1	TNF-	TNF-	NNP
cord-356188-rwf78stz	108	1	␣	␣	NNP
cord-356188-rwf78stz	108	2	and	and	CC
cord-356188-rwf78stz	108	3	IL-8	IL-8	NNP
cord-356188-rwf78stz	108	4	levels	level	NNS
cord-356188-rwf78stz	108	5	peak	peak	NN
cord-356188-rwf78stz	108	6	between	between	IN
cord-356188-rwf78stz	108	7	Day	Day	NNP
cord-356188-rwf78stz	108	8	3	3	CD
cord-356188-rwf78stz	108	9	and	and	CC
cord-356188-rwf78stz	108	10	6	6	CD
cord-356188-rwf78stz	108	11	after	after	IN
cord-356188-rwf78stz	108	12	infection	infection	NN
cord-356188-rwf78stz	108	13	as	as	IN
cord-356188-rwf78stz	108	14	symptoms	symptom	NNS
cord-356188-rwf78stz	108	15	begin	begin	VBP
cord-356188-rwf78stz	108	16	to	to	TO
cord-356188-rwf78stz	108	17	subside	subside	VB
cord-356188-rwf78stz	108	18	[	[	-LRB-
cord-356188-rwf78stz	108	19	95	95	CD
cord-356188-rwf78stz	108	20	]	]	-RRB-
cord-356188-rwf78stz	108	21	.	.	.
cord-356188-rwf78stz	109	1	Antimicrobial	antimicrobial	JJ
cord-356188-rwf78stz	109	2	peptides	peptide	NNS
cord-356188-rwf78stz	109	3	,	,	,
cord-356188-rwf78stz	109	4	such	such	JJ
cord-356188-rwf78stz	109	5	as	as	IN
cord-356188-rwf78stz	109	6	collectins	collectins	NNP
cord-356188-rwf78stz	109	7	,	,	,
cord-356188-rwf78stz	109	8	defensins	defensins	NNP
cord-356188-rwf78stz	109	9	,	,	,
cord-356188-rwf78stz	109	10	and	and	CC
cord-356188-rwf78stz	109	11	cathelicidins	cathelicidin	NNS
cord-356188-rwf78stz	109	12	,	,	,
cord-356188-rwf78stz	109	13	are	be	VBP
cord-356188-rwf78stz	109	14	important	important	JJ
cord-356188-rwf78stz	109	15	innate	innate	JJ
cord-356188-rwf78stz	109	16	effectors	effector	NNS
cord-356188-rwf78stz	109	17	in	in	IN
cord-356188-rwf78stz	109	18	the	the	DT
cord-356188-rwf78stz	109	19	human	human	JJ
cord-356188-rwf78stz	109	20	defense	defense	NN
cord-356188-rwf78stz	109	21	against	against	IN
cord-356188-rwf78stz	109	22	influenza	influenza	NN
cord-356188-rwf78stz	109	23	infection	infection	NN
cord-356188-rwf78stz	109	24	.	.	.
cord-356188-rwf78stz	110	1	Collectins	Collectins	NNP
cord-356188-rwf78stz	110	2	,	,	,
cord-356188-rwf78stz	110	3	or	or	CC
cord-356188-rwf78stz	110	4	collagenous	collagenous	JJ
cord-356188-rwf78stz	110	5	lectins	lectin	NNS
cord-356188-rwf78stz	110	6	,	,	,
cord-356188-rwf78stz	110	7	are	be	VBP
cord-356188-rwf78stz	110	8	found	find	VBN
cord-356188-rwf78stz	110	9	primarily	primarily	RB
cord-356188-rwf78stz	110	10	in	in	IN
cord-356188-rwf78stz	110	11	mucosal	mucosal	JJ
cord-356188-rwf78stz	110	12	secretions	secretion	NNS
cord-356188-rwf78stz	110	13	and	and	CC
cord-356188-rwf78stz	110	14	include	include	VBP
cord-356188-rwf78stz	110	15	SP	SP	NNP
cord-356188-rwf78stz	110	16	-	-	HYPH
cord-356188-rwf78stz	110	17	A	A	NNP
cord-356188-rwf78stz	110	18	and	and	CC
cord-356188-rwf78stz	110	19	SP	SP	NNP
cord-356188-rwf78stz	110	20	-	-	HYPH
cord-356188-rwf78stz	110	21	D	d	JJ
cord-356188-rwf78stz	110	22	;	;	:
cord-356188-rwf78stz	110	23	SP	SP	NNP
cord-356188-rwf78stz	110	24	-	-	HYPH
cord-356188-rwf78stz	110	25	D	D	NNP
cord-356188-rwf78stz	110	26	has	have	VBZ
cord-356188-rwf78stz	110	27	been	be	VBN
cord-356188-rwf78stz	110	28	shown	show	VBN
cord-356188-rwf78stz	110	29	to	to	TO
cord-356188-rwf78stz	110	30	inhibit	inhibit	VB
cord-356188-rwf78stz	110	31	HA	HA	NNP
cord-356188-rwf78stz	110	32	activity	activity	NN
cord-356188-rwf78stz	110	33	by	by	IN
cord-356188-rwf78stz	110	34	binding	bind	VBG
cord-356188-rwf78stz	110	35	to	to	IN
cord-356188-rwf78stz	110	36	N	n	NN
cord-356188-rwf78stz	110	37	-	-	HYPH
cord-356188-rwf78stz	110	38	linked	link	VBN
cord-356188-rwf78stz	110	39	,	,	,
cord-356188-rwf78stz	110	40	high	high	JJ
cord-356188-rwf78stz	110	41	-	-	HYPH
cord-356188-rwf78stz	110	42	mannose	mannose	NN
cord-356188-rwf78stz	110	43	oligosaccharides	oligosaccharide	NNS
cord-356188-rwf78stz	110	44	in	in	IN
cord-356188-rwf78stz	110	45	a	a	DT
cord-356188-rwf78stz	110	46	calcium	calcium	NN
cord-356188-rwf78stz	110	47	-	-	HYPH
cord-356188-rwf78stz	110	48	dependent	dependent	JJ
cord-356188-rwf78stz	110	49	manner	manner	NN
cord-356188-rwf78stz	110	50	,	,	,
cord-356188-rwf78stz	110	51	while	while	IN
cord-356188-rwf78stz	110	52	enhancing	enhance	VBG
cord-356188-rwf78stz	110	53	activation	activation	NN
cord-356188-rwf78stz	110	54	of	of	IN
cord-356188-rwf78stz	110	55	neutrophils	neutrophil	NNS
cord-356188-rwf78stz	110	56	in	in	IN
cord-356188-rwf78stz	110	57	in	in	FW
cord-356188-rwf78stz	110	58	vitro	vitro	FW
cord-356188-rwf78stz	110	59	assays	assay	NNS
cord-356188-rwf78stz	110	60	[	[	-LRB-
cord-356188-rwf78stz	110	61	132	132	CD
cord-356188-rwf78stz	110	62	,	,	,
cord-356188-rwf78stz	110	63	133	133	CD
cord-356188-rwf78stz	110	64	]	]	-RRB-
cord-356188-rwf78stz	110	65	.	.	.
cord-356188-rwf78stz	111	1	In	in	IN
cord-356188-rwf78stz	111	2	murine	murine	JJ
cord-356188-rwf78stz	111	3	models	model	NNS
cord-356188-rwf78stz	111	4	,	,	,
cord-356188-rwf78stz	111	5	SP	SP	NNP
cord-356188-rwf78stz	111	6	-	-	HYPH
cord-356188-rwf78stz	111	7	A	A	NNP
cord-356188-rwf78stz	111	8	and	and	CC
cord-356188-rwf78stz	111	9	SP	SP	NNP
cord-356188-rwf78stz	111	10	-	-	HYPH
cord-356188-rwf78stz	111	11	D	d	JJ
cord-356188-rwf78stz	111	12	have	have	VBP
cord-356188-rwf78stz	111	13	roles	role	NNS
cord-356188-rwf78stz	111	14	in	in	IN
cord-356188-rwf78stz	111	15	promoting	promote	VBG
cord-356188-rwf78stz	111	16	viral	viral	JJ
cord-356188-rwf78stz	111	17	clearance	clearance	NN
cord-356188-rwf78stz	111	18	from	from	IN
cord-356188-rwf78stz	111	19	lungs	lung	NNS
cord-356188-rwf78stz	111	20	and	and	CC
cord-356188-rwf78stz	111	21	reducing	reduce	VBG
cord-356188-rwf78stz	111	22	inflammatory	inflammatory	JJ
cord-356188-rwf78stz	111	23	cytokines	cytokine	NNS
cord-356188-rwf78stz	111	24	[	[	-LRB-
cord-356188-rwf78stz	111	25	134	134	CD
cord-356188-rwf78stz	111	26	,	,	,
cord-356188-rwf78stz	111	27	135	135	CD
cord-356188-rwf78stz	111	28	]	]	-RRB-
cord-356188-rwf78stz	111	29	,	,	,
cord-356188-rwf78stz	111	30	but	but	CC
cord-356188-rwf78stz	111	31	their	-PRON-	PRP$
cord-356188-rwf78stz	111	32	role	role	NN
cord-356188-rwf78stz	111	33	during	during	IN
cord-356188-rwf78stz	111	34	human	human	JJ
cord-356188-rwf78stz	111	35	influenza	influenza	NN
cord-356188-rwf78stz	111	36	infection	infection	NN
cord-356188-rwf78stz	111	37	is	be	VBZ
cord-356188-rwf78stz	111	38	less	less	RBR
cord-356188-rwf78stz	111	39	well	well	RB
cord-356188-rwf78stz	111	40	-	-	HYPH
cord-356188-rwf78stz	111	41	defined	define	VBN
cord-356188-rwf78stz	111	42	.	.	.
cord-356188-rwf78stz	112	1	Influenza	influenza	NN
cord-356188-rwf78stz	112	2	virus	virus	NN
cord-356188-rwf78stz	112	3	impairs	impair	VBZ
cord-356188-rwf78stz	112	4	calcium	calcium	NN
cord-356188-rwf78stz	112	5	metabolism	metabolism	NN
cord-356188-rwf78stz	112	6	and	and	CC
cord-356188-rwf78stz	112	7	subsequent	subsequent	JJ
cord-356188-rwf78stz	112	8	calcium	calcium	NN
cord-356188-rwf78stz	112	9	deactivation	deactivation	NN
cord-356188-rwf78stz	112	10	in	in	IN
cord-356188-rwf78stz	112	11	neutrophils	neutrophil	NNS
cord-356188-rwf78stz	112	12	[	[	-LRB-
cord-356188-rwf78stz	112	13	136	136	CD
cord-356188-rwf78stz	112	14	]	]	-RRB-
cord-356188-rwf78stz	112	15	,	,	,
cord-356188-rwf78stz	112	16	and	and	CC
cord-356188-rwf78stz	112	17	interestingly	interestingly	RB
cord-356188-rwf78stz	112	18	,	,	,
cord-356188-rwf78stz	112	19	SP	SP	NNP
cord-356188-rwf78stz	112	20	-	-	HYPH
cord-356188-rwf78stz	112	21	D	D	NNP
cord-356188-rwf78stz	112	22	can	can	MD
cord-356188-rwf78stz	112	23	protect	protect	VB
cord-356188-rwf78stz	112	24	neutrophils	neutrophil	NNS
cord-356188-rwf78stz	112	25	from	from	IN
cord-356188-rwf78stz	112	26	calcium	calcium	NN
cord-356188-rwf78stz	112	27	deactivation	deactivation	NN
cord-356188-rwf78stz	112	28	if	if	IN
cord-356188-rwf78stz	112	29	preincubated	preincubate	VBN
cord-356188-rwf78stz	112	30	with	with	IN
cord-356188-rwf78stz	112	31	virus	virus	NN
cord-356188-rwf78stz	112	32	,	,	,
cord-356188-rwf78stz	112	33	presumably	presumably	RB
cord-356188-rwf78stz	112	34	by	by	IN
cord-356188-rwf78stz	112	35	inhibiting	inhibit	VBG
cord-356188-rwf78stz	112	36	HA	HA	NNP
cord-356188-rwf78stz	112	37	activity	activity	NN
cord-356188-rwf78stz	112	38	[	[	-LRB-
cord-356188-rwf78stz	112	39	132	132	CD
cord-356188-rwf78stz	112	40	]	]	-RRB-
cord-356188-rwf78stz	112	41	.	.	.
cord-356188-rwf78stz	113	1	In	in	IN
cord-356188-rwf78stz	113	2	humans	human	NNS
cord-356188-rwf78stz	113	3	,	,	,
cord-356188-rwf78stz	113	4	the	the	DT
cord-356188-rwf78stz	113	5	only	only	JJ
cord-356188-rwf78stz	113	6	cathelicidin	cathelicidin	NNP
cord-356188-rwf78stz	113	7	,	,	,
cord-356188-rwf78stz	113	8	human	human	JJ
cord-356188-rwf78stz	113	9	cathelicidin	cathelicidin	NNP
cord-356188-rwf78stz	113	10	18	18	CD
cord-356188-rwf78stz	113	11	,	,	,
cord-356188-rwf78stz	113	12	the	the	DT
cord-356188-rwf78stz	113	13	active	active	JJ
cord-356188-rwf78stz	113	14	form	form	NN
cord-356188-rwf78stz	113	15	of	of	IN
cord-356188-rwf78stz	113	16	which	which	WDT
cord-356188-rwf78stz	113	17	is	be	VBZ
cord-356188-rwf78stz	113	18	LL-37	LL-37	NNP
cord-356188-rwf78stz	113	19	,	,	,
cord-356188-rwf78stz	113	20	is	be	VBZ
cord-356188-rwf78stz	113	21	found	find	VBN
cord-356188-rwf78stz	113	22	in	in	IN
cord-356188-rwf78stz	113	23	diverse	diverse	JJ
cord-356188-rwf78stz	113	24	cell	cell	NN
cord-356188-rwf78stz	113	25	types	type	NNS
cord-356188-rwf78stz	113	26	,	,	,
cord-356188-rwf78stz	113	27	including	include	VBG
cord-356188-rwf78stz	113	28	neutrophils	neutrophil	NNS
cord-356188-rwf78stz	113	29	,	,	,
cord-356188-rwf78stz	113	30	NK	NK	NNP
cord-356188-rwf78stz	113	31	cells	cell	NNS
cord-356188-rwf78stz	113	32	,	,	,
cord-356188-rwf78stz	113	33	monocytes	monocyte	NNS
cord-356188-rwf78stz	113	34	,	,	,
cord-356188-rwf78stz	113	35	B	b	NN
cord-356188-rwf78stz	113	36	cells	cell	NNS
cord-356188-rwf78stz	113	37	,	,	,
cord-356188-rwf78stz	113	38	␥	␥	NNP
cord-356188-rwf78stz	113	39	␦	␦	NN
cord-356188-rwf78stz	113	40	T	t	NN
cord-356188-rwf78stz	113	41	cells	cell	NNS
cord-356188-rwf78stz	113	42	,	,	,
cord-356188-rwf78stz	113	43	mast	mast	NN
cord-356188-rwf78stz	113	44	cells	cell	NNS
cord-356188-rwf78stz	113	45	,	,	,
cord-356188-rwf78stz	113	46	as	as	RB
cord-356188-rwf78stz	113	47	well	well	RB
cord-356188-rwf78stz	113	48	as	as	IN
cord-356188-rwf78stz	113	49	epithelial	epithelial	JJ
cord-356188-rwf78stz	113	50	cells	cell	NNS
cord-356188-rwf78stz	113	51	lining	line	VBG
cord-356188-rwf78stz	113	52	the	the	DT
cord-356188-rwf78stz	113	53	lungs	lung	NNS
cord-356188-rwf78stz	113	54	[	[	-LRB-
cord-356188-rwf78stz	113	55	137	137	CD
cord-356188-rwf78stz	113	56	,	,	,
cord-356188-rwf78stz	113	57	138	138	CD
cord-356188-rwf78stz	113	58	]	]	-RRB-
cord-356188-rwf78stz	113	59	.	.	.
cord-356188-rwf78stz	114	1	Like	like	IN
cord-356188-rwf78stz	114	2	surfactants	surfactant	NNS
cord-356188-rwf78stz	114	3	,	,	,
cord-356188-rwf78stz	114	4	LL-37	LL-37	NNP
cord-356188-rwf78stz	114	5	shows	show	VBZ
cord-356188-rwf78stz	114	6	antiviral	antiviral	JJ
cord-356188-rwf78stz	114	7	activity	activity	NN
cord-356188-rwf78stz	114	8	against	against	IN
cord-356188-rwf78stz	114	9	influenza	influenza	NN
cord-356188-rwf78stz	114	10	and	and	CC
cord-356188-rwf78stz	114	11	can	can	MD
cord-356188-rwf78stz	114	12	reduce	reduce	VB
cord-356188-rwf78stz	114	13	viral	viral	JJ
cord-356188-rwf78stz	114	14	titers	titer	NNS
cord-356188-rwf78stz	114	15	in	in	IN
cord-356188-rwf78stz	114	16	in	in	FW
cord-356188-rwf78stz	114	17	vitro	vitro	FW
cord-356188-rwf78stz	114	18	studies	study	NNS
cord-356188-rwf78stz	114	19	[	[	-LRB-
cord-356188-rwf78stz	114	20	139	139	CD
cord-356188-rwf78stz	114	21	]	]	-RRB-
cord-356188-rwf78stz	114	22	.	.	.
cord-356188-rwf78stz	115	1	Defensins	defensin	NNS
cord-356188-rwf78stz	115	2	have	have	VBP
cord-356188-rwf78stz	115	3	a	a	DT
cord-356188-rwf78stz	115	4	key	key	JJ
cord-356188-rwf78stz	115	5	role	role	NN
cord-356188-rwf78stz	115	6	in	in	IN
cord-356188-rwf78stz	115	7	host	host	NN
cord-356188-rwf78stz	115	8	defense	defense	NN
cord-356188-rwf78stz	115	9	and	and	CC
cord-356188-rwf78stz	115	10	act	act	NN
cord-356188-rwf78stz	115	11	primarily	primarily	RB
cord-356188-rwf78stz	115	12	to	to	TO
cord-356188-rwf78stz	115	13	disrupt	disrupt	VB
cord-356188-rwf78stz	115	14	lipid	lipid	NN
cord-356188-rwf78stz	115	15	membranes	membrane	NNS
cord-356188-rwf78stz	115	16	leading	lead	VBG
cord-356188-rwf78stz	115	17	to	to	IN
cord-356188-rwf78stz	115	18	lysis	lysis	NN
cord-356188-rwf78stz	115	19	and	and	CC
cord-356188-rwf78stz	115	20	subsequent	subsequent	JJ
cord-356188-rwf78stz	115	21	death	death	NN
cord-356188-rwf78stz	115	22	of	of	IN
cord-356188-rwf78stz	115	23	bacteria	bacteria	NNS
cord-356188-rwf78stz	115	24	,	,	,
cord-356188-rwf78stz	115	25	fungi	fungus	NNS
cord-356188-rwf78stz	115	26	,	,	,
cord-356188-rwf78stz	115	27	and	and	CC
cord-356188-rwf78stz	115	28	enveloped	envelop	VBN
cord-356188-rwf78stz	115	29	viruses	virus	NNS
cord-356188-rwf78stz	115	30	[	[	-LRB-
cord-356188-rwf78stz	115	31	140	140	CD
cord-356188-rwf78stz	115	32	]	]	-RRB-
cord-356188-rwf78stz	115	33	.	.	.
cord-356188-rwf78stz	116	1	There	there	EX
cord-356188-rwf78stz	116	2	are	be	VBP
cord-356188-rwf78stz	116	3	two	two	CD
cord-356188-rwf78stz	116	4	classes	class	NNS
cord-356188-rwf78stz	116	5	of	of	IN
cord-356188-rwf78stz	116	6	defensins	defensin	NNS
cord-356188-rwf78stz	116	7	,	,	,
cord-356188-rwf78stz	116	8	␣	␣	NNP
cord-356188-rwf78stz	116	9	-defensin	-defensin	:
cord-356188-rwf78stz	116	10	and	and	CC
cord-356188-rwf78stz	116	11	␤	␤	VBD
cord-356188-rwf78stz	116	12	-defensin	-defensin	NN
cord-356188-rwf78stz	116	13	,	,	,
cord-356188-rwf78stz	116	14	which	which	WDT
cord-356188-rwf78stz	116	15	were	be	VBD
cord-356188-rwf78stz	116	16	first	first	RB
cord-356188-rwf78stz	116	17	described	describe	VBN
cord-356188-rwf78stz	116	18	in	in	IN
cord-356188-rwf78stz	116	19	models	model	NNS
cord-356188-rwf78stz	116	20	of	of	IN
cord-356188-rwf78stz	116	21	host	host	NN
cord-356188-rwf78stz	116	22	defense	defense	NN
cord-356188-rwf78stz	116	23	against	against	IN
cord-356188-rwf78stz	116	24	bacterial	bacterial	JJ
cord-356188-rwf78stz	116	25	pathogens	pathogen	NNS
cord-356188-rwf78stz	116	26	.	.	.
cord-356188-rwf78stz	117	1	Both	both	DT
cord-356188-rwf78stz	117	2	types	type	NNS
cord-356188-rwf78stz	117	3	are	be	VBP
cord-356188-rwf78stz	117	4	found	find	VBN
cord-356188-rwf78stz	117	5	in	in	IN
cord-356188-rwf78stz	117	6	the	the	DT
cord-356188-rwf78stz	117	7	respiratory	respiratory	JJ
cord-356188-rwf78stz	117	8	and	and	CC
cord-356188-rwf78stz	117	9	gastrointestinal	gastrointestinal	JJ
cord-356188-rwf78stz	117	10	tracts	tract	NNS
cord-356188-rwf78stz	117	11	.	.	.
cord-356188-rwf78stz	118	1	The	the	DT
cord-356188-rwf78stz	118	2	␣	␣	CD
cord-356188-rwf78stz	118	3	-defensins	-defensin	VBZ
cord-356188-rwf78stz	118	4	in	in	IN
cord-356188-rwf78stz	118	5	humans	human	NNS
cord-356188-rwf78stz	118	6	include	include	VBP
cord-356188-rwf78stz	118	7	HNP-1	HNP-1	NNP
cord-356188-rwf78stz	118	8	,	,	,
cord-356188-rwf78stz	118	9	-2	-2	NNP
cord-356188-rwf78stz	118	10	,	,	,
cord-356188-rwf78stz	118	11	-3	-3	NNP
cord-356188-rwf78stz	118	12	,	,	,
cord-356188-rwf78stz	118	13	and	and	CC
cord-356188-rwf78stz	118	14	-4	-4	NNP
cord-356188-rwf78stz	118	15	,	,	,
cord-356188-rwf78stz	118	16	all	all	DT
cord-356188-rwf78stz	118	17	found	find	VBN
cord-356188-rwf78stz	118	18	in	in	IN
cord-356188-rwf78stz	118	19	high	high	JJ
cord-356188-rwf78stz	118	20	concentrations	concentration	NNS
cord-356188-rwf78stz	118	21	within	within	IN
cord-356188-rwf78stz	118	22	neutrophil	neutrophil	NN
cord-356188-rwf78stz	118	23	granules	granule	NNS
cord-356188-rwf78stz	118	24	and	and	CC
cord-356188-rwf78stz	118	25	released	release	VBN
cord-356188-rwf78stz	118	26	within	within	IN
cord-356188-rwf78stz	118	27	the	the	DT
cord-356188-rwf78stz	118	28	lungs	lung	NNS
cord-356188-rwf78stz	118	29	in	in	IN
cord-356188-rwf78stz	118	30	response	response	NN
cord-356188-rwf78stz	118	31	to	to	IN
cord-356188-rwf78stz	118	32	proinflammatory	proinflammatory	JJ
cord-356188-rwf78stz	118	33	signals	signal	NNS
cord-356188-rwf78stz	118	34	during	during	IN
cord-356188-rwf78stz	118	35	infection	infection	NN
cord-356188-rwf78stz	118	36	and	and	CC
cord-356188-rwf78stz	118	37	inflammation	inflammation	NN
cord-356188-rwf78stz	118	38	[	[	-LRB-
cord-356188-rwf78stz	118	39	141	141	CD
cord-356188-rwf78stz	118	40	]	]	-RRB-
cord-356188-rwf78stz	118	41	.	.	.
cord-356188-rwf78stz	119	1	In	in	IN
cord-356188-rwf78stz	119	2	vitro	vitro	FW
cord-356188-rwf78stz	119	3	,	,	,
cord-356188-rwf78stz	119	4	HNP-1	HNP-1	NNP
cord-356188-rwf78stz	119	5	and	and	CC
cord-356188-rwf78stz	119	6	HNP-2	HNP-2	NNP
cord-356188-rwf78stz	119	7	act	act	NN
cord-356188-rwf78stz	119	8	as	as	IN
cord-356188-rwf78stz	119	9	chemokines	chemokine	NNS
cord-356188-rwf78stz	119	10	for	for	IN
cord-356188-rwf78stz	119	11	human	human	JJ
cord-356188-rwf78stz	119	12	monocytes	monocyte	NNS
cord-356188-rwf78stz	119	13	[	[	-LRB-
cord-356188-rwf78stz	119	14	142	142	CD
cord-356188-rwf78stz	119	15	]	]	-RRB-
cord-356188-rwf78stz	119	16	,	,	,
cord-356188-rwf78stz	119	17	and	and	CC
cord-356188-rwf78stz	119	18	HNP-1	HNP-1	NNP
cord-356188-rwf78stz	119	19	,	,	,
cord-356188-rwf78stz	119	20	-2	-2	NNP
cord-356188-rwf78stz	119	21	,	,	,
cord-356188-rwf78stz	119	22	and	and	CC
cord-356188-rwf78stz	119	23	-3	-3	NNP
cord-356188-rwf78stz	119	24	can	can	MD
cord-356188-rwf78stz	119	25	induce	induce	VB
cord-356188-rwf78stz	119	26	neutrophil	neutrophil	NN
cord-356188-rwf78stz	119	27	internalization	internalization	NN
cord-356188-rwf78stz	119	28	of	of	IN
cord-356188-rwf78stz	119	29	influenza	influenza	NN
cord-356188-rwf78stz	119	30	in	in	IN
cord-356188-rwf78stz	119	31	vitro	vitro	FW
cord-356188-rwf78stz	119	32	[	[	-LRB-
cord-356188-rwf78stz	119	33	143	143	CD
cord-356188-rwf78stz	119	34	]	]	-RRB-
cord-356188-rwf78stz	119	35	.	.	.
cord-356188-rwf78stz	120	1	Moreover	moreover	RB
cord-356188-rwf78stz	120	2	,	,	,
cord-356188-rwf78stz	120	3	the	the	DT
cord-356188-rwf78stz	120	4	␣	␣	CD
cord-356188-rwf78stz	120	5	-defensins	-defensins	NNP
cord-356188-rwf78stz	120	6	may	may	MD
cord-356188-rwf78stz	120	7	have	have	VB
cord-356188-rwf78stz	120	8	a	a	DT
cord-356188-rwf78stz	120	9	role	role	NN
cord-356188-rwf78stz	120	10	in	in	IN
cord-356188-rwf78stz	120	11	directly	directly	RB
cord-356188-rwf78stz	120	12	inactivating	inactivate	VBG
cord-356188-rwf78stz	120	13	influenza	influenza	NN
cord-356188-rwf78stz	120	14	virus	virus	NN
cord-356188-rwf78stz	120	15	as	as	IN
cord-356188-rwf78stz	121	1	A	a	DT
cord-356188-rwf78stz	121	2	/	/	SYM
cord-356188-rwf78stz	121	3	WSN	WSN	NNP
cord-356188-rwf78stz	121	4	preincubated	preincubate	VBN
cord-356188-rwf78stz	121	5	with	with	IN
cord-356188-rwf78stz	121	6	HNP-1	HNP-1	NNP
cord-356188-rwf78stz	121	7	showed	show	VBD
cord-356188-rwf78stz	121	8	decreased	decrease	VBN
cord-356188-rwf78stz	121	9	infection	infection	NN
cord-356188-rwf78stz	121	10	in	in	IN
cord-356188-rwf78stz	121	11	vitro	vitro	FW
cord-356188-rwf78stz	121	12	in	in	IN
cord-356188-rwf78stz	121	13	a	a	DT
cord-356188-rwf78stz	121	14	dosedependent	dosedependent	NN
cord-356188-rwf78stz	121	15	manner	manner	NN
cord-356188-rwf78stz	121	16	[	[	-LRB-
cord-356188-rwf78stz	121	17	144	144	CD
cord-356188-rwf78stz	121	18	]	]	-RRB-
cord-356188-rwf78stz	121	19	.	.	.
cord-356188-rwf78stz	122	1	HNP-1	HNP-1	NNP
cord-356188-rwf78stz	122	2	can	can	MD
cord-356188-rwf78stz	122	3	also	also	RB
cord-356188-rwf78stz	122	4	inhibit	inhibit	VB
cord-356188-rwf78stz	122	5	influenza	influenza	NN
cord-356188-rwf78stz	122	6	virus	virus	NN
cord-356188-rwf78stz	122	7	replication	replication	NN
cord-356188-rwf78stz	122	8	via	via	IN
cord-356188-rwf78stz	122	9	modulation	modulation	NN
cord-356188-rwf78stz	122	10	of	of	IN
cord-356188-rwf78stz	122	11	cellular	cellular	JJ
cord-356188-rwf78stz	122	12	pathways	pathway	NNS
cord-356188-rwf78stz	122	13	,	,	,
cord-356188-rwf78stz	122	14	including	include	VBG
cord-356188-rwf78stz	122	15	the	the	DT
cord-356188-rwf78stz	122	16	PKC	PKC	NNP
cord-356188-rwf78stz	122	17	pathway	pathway	NN
cord-356188-rwf78stz	122	18	[	[	-LRB-
cord-356188-rwf78stz	122	19	145	145	CD
cord-356188-rwf78stz	122	20	]	]	-RRB-
cord-356188-rwf78stz	122	21	.	.	.
cord-356188-rwf78stz	123	1	Heterogeneous	heterogeneous	JJ
cord-356188-rwf78stz	123	2	populations	population	NNS
cord-356188-rwf78stz	123	3	of	of	IN
cord-356188-rwf78stz	123	4	monocytes	monocyte	NNS
cord-356188-rwf78stz	123	5	comprise	comprise	VBP
cord-356188-rwf78stz	123	6	ϳ10	ϳ10	CD
cord-356188-rwf78stz	123	7	%	%	NN
cord-356188-rwf78stz	123	8	of	of	IN
cord-356188-rwf78stz	123	9	blood	blood	NN
cord-356188-rwf78stz	123	10	leukocytes	leukocyte	NNS
cord-356188-rwf78stz	123	11	in	in	IN
cord-356188-rwf78stz	123	12	humans	human	NNS
cord-356188-rwf78stz	123	13	(	(	-LRB-
cord-356188-rwf78stz	123	14	4	4	CD
cord-356188-rwf78stz	123	15	%	%	NN
cord-356188-rwf78stz	123	16	in	in	IN
cord-356188-rwf78stz	123	17	the	the	DT
cord-356188-rwf78stz	123	18	mouse	mouse	NN
cord-356188-rwf78stz	123	19	)	)	-RRB-
cord-356188-rwf78stz	123	20	,	,	,
cord-356188-rwf78stz	123	21	and	and	CC
cord-356188-rwf78stz	123	22	their	-PRON-	PRP$
cord-356188-rwf78stz	123	23	roles	role	NNS
cord-356188-rwf78stz	123	24	in	in	IN
cord-356188-rwf78stz	123	25	controlling	control	VBG
cord-356188-rwf78stz	123	26	pathogens	pathogen	NNS
cord-356188-rwf78stz	123	27	and	and	CC
cord-356188-rwf78stz	123	28	inflammation	inflammation	NN
cord-356188-rwf78stz	123	29	can	can	MD
cord-356188-rwf78stz	123	30	be	be	VB
cord-356188-rwf78stz	123	31	characterized	characterize	VBN
cord-356188-rwf78stz	123	32	by	by	IN
cord-356188-rwf78stz	123	33	functional	functional	JJ
cord-356188-rwf78stz	123	34	cellular	cellular	JJ
cord-356188-rwf78stz	123	35	subsets	subset	NNS
cord-356188-rwf78stz	123	36	.	.	.
cord-356188-rwf78stz	124	1	Human	human	JJ
cord-356188-rwf78stz	124	2	blood	blood	NN
cord-356188-rwf78stz	124	3	monocytes	monocyte	NNS
cord-356188-rwf78stz	124	4	can	can	MD
cord-356188-rwf78stz	124	5	be	be	VB
cord-356188-rwf78stz	124	6	divided	divide	VBN
cord-356188-rwf78stz	124	7	into	into	IN
cord-356188-rwf78stz	124	8	three	three	CD
cord-356188-rwf78stz	124	9	populations	population	NNS
cord-356188-rwf78stz	124	10	based	base	VBN
cord-356188-rwf78stz	124	11	primarily	primarily	RB
cord-356188-rwf78stz	124	12	on	on	IN
cord-356188-rwf78stz	124	13	cell	cell	NN
cord-356188-rwf78stz	124	14	surface	surface	NN
cord-356188-rwf78stz	124	15	expression	expression	NN
cord-356188-rwf78stz	124	16	of	of	IN
cord-356188-rwf78stz	124	17	CD14	CD14	NNP
cord-356188-rwf78stz	124	18	(	(	-LRB-
cord-356188-rwf78stz	124	19	LPS	LPS	NNP
cord-356188-rwf78stz	124	20	receptor	receptor	NN
cord-356188-rwf78stz	124	21	)	)	-RRB-
cord-356188-rwf78stz	124	22	and	and	CC
cord-356188-rwf78stz	124	23	CD16	CD16	NNP
cord-356188-rwf78stz	124	24	(	(	-LRB-
cord-356188-rwf78stz	124	25	Fc	Fc	NNP
cord-356188-rwf78stz	124	26	␥	␥	NNP
cord-356188-rwf78stz	124	27	RIII	RIII	NNP
cord-356188-rwf78stz	124	28	)	)	-RRB-
cord-356188-rwf78stz	124	29	.	.	.
cord-356188-rwf78stz	125	1	The	the	DT
cord-356188-rwf78stz	125	2	first	first	JJ
cord-356188-rwf78stz	125	3	subgroup	subgroup	NN
cord-356188-rwf78stz	125	4	consists	consist	VBZ
cord-356188-rwf78stz	125	5	of	of	IN
cord-356188-rwf78stz	125	6	"	"	``
cord-356188-rwf78stz	125	7	classical	classical	JJ
cord-356188-rwf78stz	125	8	monocytes	monocyte	NNS
cord-356188-rwf78stz	125	9	"	"	''
cord-356188-rwf78stz	125	10	,	,	,
cord-356188-rwf78stz	125	11	characterized	characterize	VBN
cord-356188-rwf78stz	125	12	by	by	IN
cord-356188-rwf78stz	125	13	CD14	CD14	NNP
cord-356188-rwf78stz	125	14	expression	expression	NN
cord-356188-rwf78stz	125	15	and	and	CC
cord-356188-rwf78stz	125	16	lack	lack	NN
cord-356188-rwf78stz	125	17	of	of	IN
cord-356188-rwf78stz	125	18	CD16	CD16	NNP
cord-356188-rwf78stz	125	19	expression	expression	NN
cord-356188-rwf78stz	125	20	(	(	-LRB-
cord-356188-rwf78stz	125	21	CD14	CD14	NNP
cord-356188-rwf78stz	125	22	ϩ	ϩ	NNP
cord-356188-rwf78stz	125	23	CD16	CD16	NNP
cord-356188-rwf78stz	125	24	Ϫ	Ϫ	NNP
cord-356188-rwf78stz	125	25	)	)	-RRB-
cord-356188-rwf78stz	125	26	.	.	.
cord-356188-rwf78stz	126	1	The	the	DT
cord-356188-rwf78stz	126	2	CD14	CD14	NNP
cord-356188-rwf78stz	126	3	ϩ	ϩ	NN
cord-356188-rwf78stz	127	1	CD16	CD16	NNP
cord-356188-rwf78stz	127	2	Ϫ	Ϫ	NNP
cord-356188-rwf78stz	127	3	monocytes	monocyte	NNS
cord-356188-rwf78stz	127	4	comprise	comprise	VBP
cord-356188-rwf78stz	127	5	80	80	CD
cord-356188-rwf78stz	127	6	-90	-90	NN
cord-356188-rwf78stz	127	7	%	%	NN
cord-356188-rwf78stz	127	8	of	of	IN
cord-356188-rwf78stz	127	9	blood	blood	NN
cord-356188-rwf78stz	127	10	monocytes	monocyte	NNS
cord-356188-rwf78stz	127	11	and	and	CC
cord-356188-rwf78stz	127	12	resemble	resemble	VB
cord-356188-rwf78stz	127	13	murine	murine	JJ
cord-356188-rwf78stz	127	14	inflammatory	inflammatory	JJ
cord-356188-rwf78stz	127	15	Ly6C	ly6c	NN
cord-356188-rwf78stz	127	16	ϩ	ϩ	NN
cord-356188-rwf78stz	127	17	(	(	-LRB-
cord-356188-rwf78stz	127	18	Gr1	gr1	NN
cord-356188-rwf78stz	127	19	ϩ	ϩ	NNP
cord-356188-rwf78stz	127	20	)	)	-RRB-
cord-356188-rwf78stz	127	21	monocytes	monocyte	VBZ
cord-356188-rwf78stz	127	22	[	[	-LRB-
cord-356188-rwf78stz	127	23	146	146	CD
cord-356188-rwf78stz	127	24	]	]	-RRB-
cord-356188-rwf78stz	127	25	.	.	.
cord-356188-rwf78stz	128	1	The	the	DT
cord-356188-rwf78stz	128	2	second	second	JJ
cord-356188-rwf78stz	128	3	subgroup	subgroup	NN
cord-356188-rwf78stz	128	4	is	be	VBZ
cord-356188-rwf78stz	128	5	defined	define	VBN
cord-356188-rwf78stz	128	6	by	by	IN
cord-356188-rwf78stz	128	7	high	high	JJ
cord-356188-rwf78stz	128	8	expression	expression	NN
cord-356188-rwf78stz	128	9	of	of	IN
cord-356188-rwf78stz	128	10	CD14	CD14	NNP
cord-356188-rwf78stz	128	11	and	and	CC
cord-356188-rwf78stz	128	12	CD16	CD16	NNP
cord-356188-rwf78stz	128	13	(	(	-LRB-
cord-356188-rwf78stz	128	14	CD14	CD14	NNP
cord-356188-rwf78stz	128	15	ϩ	ϩ	NNP
cord-356188-rwf78stz	129	1	CD16	CD16	NNP
cord-356188-rwf78stz	129	2	ϩ	ϩ	CD
cord-356188-rwf78stz	129	3	)	)	-RRB-
cord-356188-rwf78stz	129	4	and	and	CC
cord-356188-rwf78stz	129	5	release	release	VB
cord-356188-rwf78stz	129	6	TNF	TNF	NNP
cord-356188-rwf78stz	129	7	following	follow	VBG
cord-356188-rwf78stz	129	8	LPS	LPS	NNP
cord-356188-rwf78stz	129	9	stimulation	stimulation	NN
cord-356188-rwf78stz	129	10	[	[	-LRB-
cord-356188-rwf78stz	129	11	147	147	CD
cord-356188-rwf78stz	129	12	]	]	-RRB-
cord-356188-rwf78stz	129	13	.	.	.
cord-356188-rwf78stz	130	1	The	the	DT
cord-356188-rwf78stz	130	2	third	third	JJ
cord-356188-rwf78stz	130	3	monocytic	monocytic	JJ
cord-356188-rwf78stz	130	4	subgroup	subgroup	NN
cord-356188-rwf78stz	130	5	is	be	VBZ
cord-356188-rwf78stz	130	6	characterized	characterize	VBN
cord-356188-rwf78stz	130	7	by	by	IN
cord-356188-rwf78stz	130	8	low	low	JJ
cord-356188-rwf78stz	130	9	expression	expression	NN
cord-356188-rwf78stz	130	10	of	of	IN
cord-356188-rwf78stz	130	11	CD14	CD14	NNP
cord-356188-rwf78stz	130	12	and	and	CC
cord-356188-rwf78stz	130	13	high	high	JJ
cord-356188-rwf78stz	130	14	expression	expression	NN
cord-356188-rwf78stz	130	15	of	of	IN
cord-356188-rwf78stz	130	16	CD16	CD16	NNP
cord-356188-rwf78stz	130	17	(	(	-LRB-
cord-356188-rwf78stz	130	18	CD14	CD14	NNP
cord-356188-rwf78stz	130	19	dim	dim	JJ
cord-356188-rwf78stz	130	20	CD16	CD16	NNP
cord-356188-rwf78stz	130	21	ϩ	ϩ	NNP
cord-356188-rwf78stz	130	22	)	)	-RRB-
cord-356188-rwf78stz	130	23	,	,	,
cord-356188-rwf78stz	130	24	and	and	CC
cord-356188-rwf78stz	130	25	at	at	RB
cord-356188-rwf78stz	130	26	least	least	RBS
cord-356188-rwf78stz	130	27	one	one	CD
cord-356188-rwf78stz	130	28	study	study	NN
cord-356188-rwf78stz	130	29	has	have	VBZ
cord-356188-rwf78stz	130	30	shown	show	VBN
cord-356188-rwf78stz	130	31	increased	increase	VBN
cord-356188-rwf78stz	130	32	numbers	number	NNS
cord-356188-rwf78stz	130	33	in	in	IN
cord-356188-rwf78stz	130	34	the	the	DT
cord-356188-rwf78stz	130	35	blood	blood	NN
cord-356188-rwf78stz	130	36	of	of	IN
cord-356188-rwf78stz	130	37	sepsis	sepsis	NN
cord-356188-rwf78stz	130	38	patients	patient	NNS
cord-356188-rwf78stz	130	39	[	[	-LRB-
cord-356188-rwf78stz	130	40	148	148	CD
cord-356188-rwf78stz	130	41	]	]	-RRB-
cord-356188-rwf78stz	130	42	.	.	.
cord-356188-rwf78stz	131	1	CD14	CD14	NNP
cord-356188-rwf78stz	131	2	dim	dim	JJ
cord-356188-rwf78stz	131	3	blood	blood	NN
cord-356188-rwf78stz	131	4	monocytes	monocyte	NNS
cord-356188-rwf78stz	131	5	function	function	NN
cord-356188-rwf78stz	131	6	as	as	IN
cord-356188-rwf78stz	131	7	efficient	efficient	JJ
cord-356188-rwf78stz	131	8	producers	producer	NNS
cord-356188-rwf78stz	131	9	of	of	IN
cord-356188-rwf78stz	131	10	proinflammatory	proinflammatory	JJ
cord-356188-rwf78stz	131	11	cytokines	cytokine	NNS
cord-356188-rwf78stz	131	12	in	in	IN
cord-356188-rwf78stz	131	13	response	response	NN
cord-356188-rwf78stz	131	14	to	to	IN
cord-356188-rwf78stz	131	15	viruses	virus	NNS
cord-356188-rwf78stz	131	16	and	and	CC
cord-356188-rwf78stz	131	17	nucleic	nucleic	JJ
cord-356188-rwf78stz	131	18	acids	acid	NNS
cord-356188-rwf78stz	131	19	[	[	-LRB-
cord-356188-rwf78stz	131	20	149	149	CD
cord-356188-rwf78stz	131	21	,	,	,
cord-356188-rwf78stz	131	22	150	150	CD
cord-356188-rwf78stz	131	23	]	]	-RRB-
cord-356188-rwf78stz	131	24	.	.	.
cord-356188-rwf78stz	132	1	Few	few	JJ
cord-356188-rwf78stz	132	2	studies	study	NNS
cord-356188-rwf78stz	132	3	have	have	VBP
cord-356188-rwf78stz	132	4	examined	examine	VBN
cord-356188-rwf78stz	132	5	the	the	DT
cord-356188-rwf78stz	132	6	role	role	NN
cord-356188-rwf78stz	132	7	of	of	IN
cord-356188-rwf78stz	132	8	monocytes	monocyte	NNS
cord-356188-rwf78stz	132	9	during	during	IN
cord-356188-rwf78stz	132	10	influenza	influenza	JJ
cord-356188-rwf78stz	132	11	infection	infection	NN
cord-356188-rwf78stz	132	12	in	in	IN
cord-356188-rwf78stz	132	13	humans	human	NNS
cord-356188-rwf78stz	132	14	,	,	,
cord-356188-rwf78stz	132	15	particularly	particularly	RB
cord-356188-rwf78stz	132	16	regarding	regard	VBG
cord-356188-rwf78stz	132	17	the	the	DT
cord-356188-rwf78stz	132	18	specific	specific	JJ
cord-356188-rwf78stz	132	19	subsets	subset	NNS
cord-356188-rwf78stz	132	20	mentioned	mention	VBN
cord-356188-rwf78stz	132	21	above	above	RB
cord-356188-rwf78stz	132	22	,	,	,
cord-356188-rwf78stz	132	23	but	but	CC
cord-356188-rwf78stz	132	24	comparison	comparison	NN
cord-356188-rwf78stz	132	25	of	of	IN
cord-356188-rwf78stz	132	26	IFN-	IFN-	NNP
cord-356188-rwf78stz	132	27	␥	␥	CD
cord-356188-rwf78stz	132	28	production	production	NN
cord-356188-rwf78stz	132	29	from	from	IN
cord-356188-rwf78stz	132	30	T	t	NN
cord-356188-rwf78stz	132	31	cells	cell	NNS
cord-356188-rwf78stz	132	32	cocultured	coculture	VBN
cord-356188-rwf78stz	132	33	with	with	IN
cord-356188-rwf78stz	132	34	CD64	CD64	NNP
cord-356188-rwf78stz	133	1	ϩ	ϩ	LS
cord-356188-rwf78stz	134	1	CD16	CD16	NNP
cord-356188-rwf78stz	134	2	Ϫ	Ϫ	NNP
cord-356188-rwf78stz	134	3	and	and	CC
cord-356188-rwf78stz	134	4	CD64	CD64	NNP
cord-356188-rwf78stz	135	1	Ϫ	ϫ	NN
cord-356188-rwf78stz	136	1	CD16	CD16	NNP
cord-356188-rwf78stz	137	1	ϩ	ϩ	LS
cord-356188-rwf78stz	137	2	monocytes	monocyte	VBZ
cord-356188-rwf78stz	137	3	[	[	-LRB-
cord-356188-rwf78stz	137	4	119	119	CD
cord-356188-rwf78stz	137	5	,	,	,
cord-356188-rwf78stz	137	6	120	120	CD
cord-356188-rwf78stz	137	7	]	]	-RRB-
cord-356188-rwf78stz	138	1	Cellular	cellular	JJ
cord-356188-rwf78stz	138	2	immunity	immunity	NN
cord-356188-rwf78stz	138	3	Class	class	NN
cord-356188-rwf78stz	139	1	I	-PRON-	PRP
cord-356188-rwf78stz	139	2	HLA	HLA	NNP
cord-356188-rwf78stz	139	3	presents	present	VBZ
cord-356188-rwf78stz	139	4	peptides	peptide	NNS
cord-356188-rwf78stz	139	5	from	from	IN
cord-356188-rwf78stz	139	6	internal	internal	JJ
cord-356188-rwf78stz	139	7	and	and	CC
cord-356188-rwf78stz	139	8	external	external	JJ
cord-356188-rwf78stz	139	9	viral	viral	JJ
cord-356188-rwf78stz	139	10	proteins	protein	NNS
cord-356188-rwf78stz	139	11	.	.	.
cord-356188-rwf78stz	140	1	[	[	-LRB-
cord-356188-rwf78stz	140	2	121	121	CD
cord-356188-rwf78stz	140	3	,	,	,
cord-356188-rwf78stz	140	4	122	122	CD
cord-356188-rwf78stz	140	5	]	]	-RRB-
cord-356188-rwf78stz	140	6	showed	show	VBD
cord-356188-rwf78stz	140	7	that	that	IN
cord-356188-rwf78stz	140	8	CD64	CD64	NNP
cord-356188-rwf78stz	141	1	Ϫ	ϫ	NN
cord-356188-rwf78stz	142	1	CD16	CD16	NNP
cord-356188-rwf78stz	142	2	ϩ	ϩ	NN
cord-356188-rwf78stz	142	3	monocytes	monocyte	NNS
cord-356188-rwf78stz	142	4	(	(	-LRB-
cord-356188-rwf78stz	142	5	equivalent	equivalent	JJ
cord-356188-rwf78stz	142	6	to	to	IN
cord-356188-rwf78stz	142	7	the	the	DT
cord-356188-rwf78stz	142	8	CD14	CD14	NNP
cord-356188-rwf78stz	142	9	ϩ	ϩ	NNP
cord-356188-rwf78stz	142	10	CD16	CD16	NNP
cord-356188-rwf78stz	142	11	ϩ	ϩ	NN
cord-356188-rwf78stz	142	12	monocytes	monocyte	NNS
cord-356188-rwf78stz	142	13	)	)	-RRB-
cord-356188-rwf78stz	142	14	induced	induce	VBD
cord-356188-rwf78stz	142	15	a	a	DT
cord-356188-rwf78stz	142	16	greater	great	JJR
cord-356188-rwf78stz	142	17	response	response	NN
cord-356188-rwf78stz	142	18	to	to	TO
cord-356188-rwf78stz	142	19	influenza	influenza	VB
cord-356188-rwf78stz	142	20	A	a	DT
cord-356188-rwf78stz	142	21	antigen	antigen	NN
cord-356188-rwf78stz	142	22	[	[	-LRB-
cord-356188-rwf78stz	142	23	151	151	CD
cord-356188-rwf78stz	142	24	]	]	-RRB-
cord-356188-rwf78stz	142	25	.	.	.
cord-356188-rwf78stz	143	1	In	in	IN
cord-356188-rwf78stz	143	2	vitro	vitro	FW
cord-356188-rwf78stz	143	3	,	,	,
cord-356188-rwf78stz	143	4	human	human	JJ
cord-356188-rwf78stz	143	5	DCs	dc	NNS
cord-356188-rwf78stz	143	6	and	and	CC
cord-356188-rwf78stz	143	7	macrophages	macrophage	NNS
cord-356188-rwf78stz	143	8	treated	treat	VBN
cord-356188-rwf78stz	143	9	with	with	IN
cord-356188-rwf78stz	143	10	type	type	NN
cord-356188-rwf78stz	143	11	I	-PRON-	PRP
cord-356188-rwf78stz	143	12	or	or	CC
cord-356188-rwf78stz	143	13	type	type	NN
cord-356188-rwf78stz	143	14	III	III	NNP
cord-356188-rwf78stz	143	15	IFN	IFN	NNP
cord-356188-rwf78stz	143	16	prior	prior	RB
cord-356188-rwf78stz	143	17	to	to	IN
cord-356188-rwf78stz	143	18	influenza	influenza	NN
cord-356188-rwf78stz	143	19	infection	infection	NN
cord-356188-rwf78stz	143	20	result	result	NN
cord-356188-rwf78stz	143	21	in	in	IN
cord-356188-rwf78stz	143	22	potent	potent	JJ
cord-356188-rwf78stz	143	23	antiviral	antiviral	JJ
cord-356188-rwf78stz	143	24	activity	activity	NN
cord-356188-rwf78stz	143	25	and	and	CC
cord-356188-rwf78stz	143	26	decreased	decrease	VBD
cord-356188-rwf78stz	143	27	viral	viral	JJ
cord-356188-rwf78stz	143	28	replication	replication	NN
cord-356188-rwf78stz	143	29	[	[	-LRB-
cord-356188-rwf78stz	143	30	127	127	CD
cord-356188-rwf78stz	143	31	]	]	-RRB-
cord-356188-rwf78stz	143	32	.	.	.
cord-356188-rwf78stz	144	1	Among	among	IN
cord-356188-rwf78stz	144	2	DC	DC	NNP
cord-356188-rwf78stz	144	3	populations	population	NNS
cord-356188-rwf78stz	144	4	,	,	,
cord-356188-rwf78stz	144	5	CD11c	CD11c	NNP
cord-356188-rwf78stz	144	6	Ϫ	Ϫ	NNP
cord-356188-rwf78stz	144	7	CD14	CD14	NNP
cord-356188-rwf78stz	144	8	Ϫ	Ϫ	NNP
cord-356188-rwf78stz	144	9	HLA	HLA	NNP
cord-356188-rwf78stz	144	10	-	-	HYPH
cord-356188-rwf78stz	144	11	DR	DR	NNP
cord-356188-rwf78stz	145	1	ϩ	ϩ	LS
cord-356188-rwf78stz	145	2	CD123	CD123	NNP
cord-356188-rwf78stz	146	1	ϩ	ϩ	LS
cord-356188-rwf78stz	147	1	pDCs	pDCs	NNP
cord-356188-rwf78stz	147	2	were	be	VBD
cord-356188-rwf78stz	147	3	found	find	VBN
cord-356188-rwf78stz	147	4	to	to	TO
cord-356188-rwf78stz	147	5	produce	produce	VB
cord-356188-rwf78stz	147	6	more	more	JJR
cord-356188-rwf78stz	147	7	IFN-	IFN-	NNP
cord-356188-rwf78stz	148	1	␣	␣	NNP
cord-356188-rwf78stz	148	2	in	in	IN
cord-356188-rwf78stz	148	3	response	response	NN
cord-356188-rwf78stz	148	4	to	to	IN
cord-356188-rwf78stz	148	5	a	a	DT
cord-356188-rwf78stz	148	6	high	high	JJ
cord-356188-rwf78stz	148	7	dose	dose	NN
cord-356188-rwf78stz	148	8	of	of	IN
cord-356188-rwf78stz	148	9	A	a	NN
cord-356188-rwf78stz	148	10	/	/	SYM
cord-356188-rwf78stz	148	11	PR8/8/34	PR8/8/34	NNP
cord-356188-rwf78stz	148	12	(	(	-LRB-
cord-356188-rwf78stz	148	13	H1N1	H1N1	NNP
cord-356188-rwf78stz	148	14	)	)	-RRB-
cord-356188-rwf78stz	149	1	[	[	-LRB-
cord-356188-rwf78stz	149	2	152	152	CD
cord-356188-rwf78stz	149	3	]	]	-RRB-
cord-356188-rwf78stz	149	4	.	.	.
cord-356188-rwf78stz	150	1	Whereas	whereas	IN
cord-356188-rwf78stz	150	2	increased	increase	VBN
cord-356188-rwf78stz	150	3	numbers	number	NNS
cord-356188-rwf78stz	150	4	of	of	IN
cord-356188-rwf78stz	150	5	total	total	JJ
cord-356188-rwf78stz	150	6	CD14	CD14	NNP
cord-356188-rwf78stz	150	7	ϩ	ϩ	NN
cord-356188-rwf78stz	150	8	cells	cell	NNS
cord-356188-rwf78stz	150	9	are	be	VBP
cord-356188-rwf78stz	150	10	observed	observe	VBN
cord-356188-rwf78stz	150	11	in	in	IN
cord-356188-rwf78stz	150	12	the	the	DT
cord-356188-rwf78stz	150	13	blood	blood	NN
cord-356188-rwf78stz	150	14	of	of	IN
cord-356188-rwf78stz	150	15	influenza	influenza	NN
cord-356188-rwf78stz	150	16	-	-	HYPH
cord-356188-rwf78stz	150	17	infected	infect	VBN
cord-356188-rwf78stz	150	18	individuals	individual	NNS
cord-356188-rwf78stz	150	19	,	,	,
cord-356188-rwf78stz	150	20	decreased	decrease	VBD
cord-356188-rwf78stz	150	21	blood	blood	NN
cord-356188-rwf78stz	150	22	myeloid	myeloid	NN
cord-356188-rwf78stz	150	23	DCs	DCs	NNP
cord-356188-rwf78stz	150	24	and	and	CC
cord-356188-rwf78stz	150	25	pDCs	pDCs	NNP
cord-356188-rwf78stz	150	26	were	be	VBD
cord-356188-rwf78stz	150	27	observed	observe	VBN
cord-356188-rwf78stz	150	28	(	(	-LRB-
cord-356188-rwf78stz	150	29	defined	define	VBN
cord-356188-rwf78stz	150	30	in	in	IN
cord-356188-rwf78stz	150	31	this	this	DT
cord-356188-rwf78stz	150	32	study	study	NN
cord-356188-rwf78stz	150	33	as	as	IN
cord-356188-rwf78stz	150	34	HLA	HLA	NNP
cord-356188-rwf78stz	150	35	-	-	HYPH
cord-356188-rwf78stz	150	36	DR	DR	NNP
cord-356188-rwf78stz	150	37	ϩ	ϩ	NNP
cord-356188-rwf78stz	151	1	CD14	CD14	NNP
cord-356188-rwf78stz	151	2	Ϫ	Ϫ	NNP
cord-356188-rwf78stz	151	3	CD16	CD16	NNP
cord-356188-rwf78stz	151	4	Ϫ	Ϫ	NNP
cord-356188-rwf78stz	152	1	CD11c	CD11c	NNP
cord-356188-rwf78stz	152	2	ϩ	ϩ	NN
cord-356188-rwf78stz	152	3	and	and	CC
cord-356188-rwf78stz	152	4	HLA	HLA	NNP
cord-356188-rwf78stz	152	5	-	-	HYPH
cord-356188-rwf78stz	152	6	DR	DR	NNP
cord-356188-rwf78stz	152	7	ϩ	ϩ	NNP
cord-356188-rwf78stz	153	1	CD14	CD14	NNP
cord-356188-rwf78stz	153	2	Ϫ	Ϫ	NNP
cord-356188-rwf78stz	153	3	CD16	CD16	NNP
cord-356188-rwf78stz	153	4	Ϫ	Ϫ	NNP
cord-356188-rwf78stz	154	1	CD123	CD123	NNP
cord-356188-rwf78stz	154	2	ϩ	ϩ	NNP
cord-356188-rwf78stz	154	3	,	,	,
cord-356188-rwf78stz	154	4	respectively	respectively	RB
cord-356188-rwf78stz	154	5	)	)	-RRB-
cord-356188-rwf78stz	154	6	[	[	-LRB-
cord-356188-rwf78stz	154	7	153	153	CD
cord-356188-rwf78stz	154	8	]	]	-RRB-
cord-356188-rwf78stz	154	9	.	.	.
cord-356188-rwf78stz	155	1	However	however	RB
cord-356188-rwf78stz	155	2	,	,	,
cord-356188-rwf78stz	155	3	increased	increase	VBN
cord-356188-rwf78stz	155	4	numbers	number	NNS
cord-356188-rwf78stz	155	5	of	of	IN
cord-356188-rwf78stz	155	6	pDCs	pDCs	NNP
cord-356188-rwf78stz	155	7	were	be	VBD
cord-356188-rwf78stz	155	8	observed	observe	VBN
cord-356188-rwf78stz	155	9	in	in	IN
cord-356188-rwf78stz	155	10	nasal	nasal	JJ
cord-356188-rwf78stz	155	11	secretions	secretion	NNS
cord-356188-rwf78stz	155	12	compared	compare	VBN
cord-356188-rwf78stz	155	13	with	with	IN
cord-356188-rwf78stz	155	14	healthy	healthy	JJ
cord-356188-rwf78stz	155	15	controls	control	NNS
cord-356188-rwf78stz	155	16	within	within	IN
cord-356188-rwf78stz	155	17	this	this	DT
cord-356188-rwf78stz	155	18	cohort	cohort	NN
cord-356188-rwf78stz	155	19	.	.	.
cord-356188-rwf78stz	156	1	The	the	DT
cord-356188-rwf78stz	156	2	NS1	ns1	NN
cord-356188-rwf78stz	156	3	protein	protein	NN
cord-356188-rwf78stz	156	4	is	be	VBZ
cord-356188-rwf78stz	156	5	a	a	DT
cord-356188-rwf78stz	156	6	well	well	RB
cord-356188-rwf78stz	156	7	-	-	HYPH
cord-356188-rwf78stz	156	8	characterized	characterize	VBN
cord-356188-rwf78stz	156	9	antagonist	antagonist	NN
cord-356188-rwf78stz	156	10	of	of	IN
cord-356188-rwf78stz	156	11	the	the	DT
cord-356188-rwf78stz	156	12	host	host	NN
cord-356188-rwf78stz	156	13	's	's	POS
cord-356188-rwf78stz	156	14	antiviral	antiviral	JJ
cord-356188-rwf78stz	156	15	response	response	NN
cord-356188-rwf78stz	156	16	,	,	,
cord-356188-rwf78stz	156	17	acting	act	VBG
cord-356188-rwf78stz	156	18	primarily	primarily	RB
cord-356188-rwf78stz	156	19	to	to	TO
cord-356188-rwf78stz	156	20	circumvent	circumvent	VB
cord-356188-rwf78stz	156	21	IFN-	IFN-	NNP
cord-356188-rwf78stz	156	22	␣	␣	NN
cord-356188-rwf78stz	156	23	/	/	SYM
cord-356188-rwf78stz	156	24	␤	␤	IN
cord-356188-rwf78stz	156	25	responses	response	NNS
cord-356188-rwf78stz	156	26	(	(	-LRB-
cord-356188-rwf78stz	156	27	reviewed	review	VBN
cord-356188-rwf78stz	156	28	in	in	IN
cord-356188-rwf78stz	156	29	ref	ref	NN
cord-356188-rwf78stz	156	30	.	.	.
cord-356188-rwf78stz	157	1	[	[	-LRB-
cord-356188-rwf78stz	157	2	154	154	CD
cord-356188-rwf78stz	157	3	]	]	-RRB-
cord-356188-rwf78stz	157	4	)	)	-RRB-
cord-356188-rwf78stz	157	5	,	,	,
cord-356188-rwf78stz	157	6	and	and	CC
cord-356188-rwf78stz	157	7	in	in	IN
cord-356188-rwf78stz	157	8	vivo	vivo	NNP
cord-356188-rwf78stz	157	9	models	model	NNS
cord-356188-rwf78stz	157	10	show	show	VBP
cord-356188-rwf78stz	157	11	that	that	IN
cord-356188-rwf78stz	157	12	its	-PRON-	PRP$
cord-356188-rwf78stz	157	13	deletion	deletion	NN
cord-356188-rwf78stz	157	14	results	result	NNS
cord-356188-rwf78stz	157	15	in	in	IN
cord-356188-rwf78stz	157	16	virus	virus	NN
cord-356188-rwf78stz	157	17	attenuation	attenuation	NN
cord-356188-rwf78stz	157	18	and	and	CC
cord-356188-rwf78stz	157	19	higher	high	JJR
cord-356188-rwf78stz	157	20	levels	level	NNS
cord-356188-rwf78stz	157	21	of	of	IN
cord-356188-rwf78stz	157	22	IFN	IFN	NNP
cord-356188-rwf78stz	157	23	[	[	-LRB-
cord-356188-rwf78stz	157	24	155	155	CD
cord-356188-rwf78stz	157	25	]	]	-RRB-
cord-356188-rwf78stz	157	26	.	.	.
cord-356188-rwf78stz	158	1	Type	type	NN
cord-356188-rwf78stz	158	2	I	-PRON-	PRP
cord-356188-rwf78stz	158	3	IFN	IFN	NNP
cord-356188-rwf78stz	158	4	antagonism	antagonism	NN
cord-356188-rwf78stz	158	5	can	can	MD
cord-356188-rwf78stz	158	6	result	result	VB
cord-356188-rwf78stz	158	7	in	in	IN
cord-356188-rwf78stz	158	8	inhibition	inhibition	NN
cord-356188-rwf78stz	158	9	of	of	IN
cord-356188-rwf78stz	158	10	adaptive	adaptive	JJ
cord-356188-rwf78stz	158	11	immunity	immunity	NN
cord-356188-rwf78stz	158	12	by	by	IN
cord-356188-rwf78stz	158	13	interfering	interfere	VBG
cord-356188-rwf78stz	158	14	with	with	IN
cord-356188-rwf78stz	158	15	DC	DC	NNP
cord-356188-rwf78stz	158	16	maturation	maturation	NN
cord-356188-rwf78stz	158	17	and	and	CC
cord-356188-rwf78stz	158	18	thus	thus	RB
cord-356188-rwf78stz	158	19	,	,	,
cord-356188-rwf78stz	158	20	the	the	DT
cord-356188-rwf78stz	158	21	ability	ability	NN
cord-356188-rwf78stz	158	22	of	of	IN
cord-356188-rwf78stz	158	23	DCs	dc	NNS
cord-356188-rwf78stz	158	24	to	to	TO
cord-356188-rwf78stz	158	25	activate	activate	VB
cord-356188-rwf78stz	158	26	T	T	NNP
cord-356188-rwf78stz	158	27	cells	cell	NNS
cord-356188-rwf78stz	158	28	[	[	-LRB-
cord-356188-rwf78stz	158	29	126	126	CD
cord-356188-rwf78stz	158	30	]	]	-RRB-
cord-356188-rwf78stz	158	31	.	.	.
cord-356188-rwf78stz	159	1	The	the	DT
cord-356188-rwf78stz	159	2	NS1	ns1	NN
cord-356188-rwf78stz	159	3	protein	protein	NN
cord-356188-rwf78stz	159	4	from	from	IN
cord-356188-rwf78stz	159	5	influenza	influenza	NN
cord-356188-rwf78stz	159	6	B	B	NNP
cord-356188-rwf78stz	159	7	virus	virus	NN
cord-356188-rwf78stz	159	8	inhibits	inhibit	VBZ
cord-356188-rwf78stz	159	9	ISGylation	ISGylation	NNP
cord-356188-rwf78stz	159	10	,	,	,
cord-356188-rwf78stz	159	11	an	an	DT
cord-356188-rwf78stz	159	12	important	important	JJ
cord-356188-rwf78stz	159	13	host	host	NN
cord-356188-rwf78stz	159	14	antiviral	antiviral	JJ
cord-356188-rwf78stz	159	15	effector	effector	NN
cord-356188-rwf78stz	159	16	mechanism	mechanism	NN
cord-356188-rwf78stz	159	17	,	,	,
cord-356188-rwf78stz	159	18	by	by	IN
cord-356188-rwf78stz	159	19	interacting	interact	VBG
cord-356188-rwf78stz	159	20	with	with	IN
cord-356188-rwf78stz	159	21	the	the	DT
cord-356188-rwf78stz	159	22	N	n	CD
cord-356188-rwf78stz	159	23	-	-	HYPH
cord-356188-rwf78stz	159	24	terminal	terminal	NN
cord-356188-rwf78stz	159	25	domain	domain	NN
cord-356188-rwf78stz	159	26	of	of	IN
cord-356188-rwf78stz	159	27	ISG15	isg15	NN
cord-356188-rwf78stz	159	28	[	[	-LRB-
cord-356188-rwf78stz	159	29	156	156	CD
cord-356188-rwf78stz	159	30	]	]	-RRB-
cord-356188-rwf78stz	159	31	.	.	.
cord-356188-rwf78stz	160	1	Murine	murine	JJ
cord-356188-rwf78stz	160	2	models	model	NNS
cord-356188-rwf78stz	160	3	have	have	VBP
cord-356188-rwf78stz	160	4	provided	provide	VBN
cord-356188-rwf78stz	160	5	several	several	JJ
cord-356188-rwf78stz	160	6	clues	clue	NNS
cord-356188-rwf78stz	160	7	regarding	regard	VBG
cord-356188-rwf78stz	160	8	the	the	DT
cord-356188-rwf78stz	160	9	actual	actual	JJ
cord-356188-rwf78stz	160	10	role	role	NN
cord-356188-rwf78stz	160	11	of	of	IN
cord-356188-rwf78stz	160	12	monocytes	monocyte	NNS
cord-356188-rwf78stz	160	13	during	during	IN
cord-356188-rwf78stz	160	14	the	the	DT
cord-356188-rwf78stz	160	15	innate	innate	JJ
cord-356188-rwf78stz	160	16	immune	immune	JJ
cord-356188-rwf78stz	160	17	response	response	NN
cord-356188-rwf78stz	160	18	to	to	IN
cord-356188-rwf78stz	160	19	influenza	influenza	NN
cord-356188-rwf78stz	160	20	infection	infection	NN
cord-356188-rwf78stz	160	21	.	.	.
cord-356188-rwf78stz	161	1	In	in	IN
cord-356188-rwf78stz	161	2	vivo	vivo	NN
cord-356188-rwf78stz	161	3	,	,	,
cord-356188-rwf78stz	161	4	CCR2-dependent	CCR2-dependent	NNP
cord-356188-rwf78stz	161	5	recruitment	recruitment	NN
cord-356188-rwf78stz	161	6	of	of	IN
cord-356188-rwf78stz	161	7	inflammatory	inflammatory	JJ
cord-356188-rwf78stz	161	8	monocytes	monocyte	NNS
cord-356188-rwf78stz	161	9	is	be	VBZ
cord-356188-rwf78stz	161	10	critical	critical	JJ
cord-356188-rwf78stz	161	11	for	for	IN
cord-356188-rwf78stz	161	12	host	host	NN
cord-356188-rwf78stz	161	13	defense	defense	NN
cord-356188-rwf78stz	161	14	and	and	CC
cord-356188-rwf78stz	161	15	contributes	contribute	VBZ
cord-356188-rwf78stz	161	16	to	to	IN
cord-356188-rwf78stz	161	17	the	the	DT
cord-356188-rwf78stz	161	18	innate	innate	JJ
cord-356188-rwf78stz	161	19	immune	immune	JJ
cord-356188-rwf78stz	161	20	response	response	NN
cord-356188-rwf78stz	161	21	,	,	,
cord-356188-rwf78stz	161	22	as	as	RB
cord-356188-rwf78stz	161	23	well	well	RB
cord-356188-rwf78stz	161	24	as	as	IN
cord-356188-rwf78stz	161	25	downstream	downstream	JJ
cord-356188-rwf78stz	161	26	adaptive	adaptive	JJ
cord-356188-rwf78stz	161	27	responses	response	NNS
cord-356188-rwf78stz	161	28	[	[	-LRB-
cord-356188-rwf78stz	161	29	157	157	CD
cord-356188-rwf78stz	161	30	]	]	-RRB-
cord-356188-rwf78stz	161	31	.	.	.
cord-356188-rwf78stz	162	1	During	during	IN
cord-356188-rwf78stz	162	2	influenza	influenza	NN
cord-356188-rwf78stz	162	3	infection	infection	NN
cord-356188-rwf78stz	162	4	,	,	,
cord-356188-rwf78stz	162	5	CCR2deficient	CCR2deficient	NNP
cord-356188-rwf78stz	162	6	mice	mouse	NNS
cord-356188-rwf78stz	162	7	have	have	VBP
cord-356188-rwf78stz	162	8	reduced	reduce	VBN
cord-356188-rwf78stz	162	9	monocyte	monocyte	NNP
cord-356188-rwf78stz	162	10	and	and	CC
cord-356188-rwf78stz	162	11	increased	increased	JJ
cord-356188-rwf78stz	162	12	neutrophil	neutrophil	NN
cord-356188-rwf78stz	162	13	recruitment	recruitment	NN
cord-356188-rwf78stz	162	14	,	,	,
cord-356188-rwf78stz	162	15	but	but	CC
cord-356188-rwf78stz	162	16	,	,	,
cord-356188-rwf78stz	162	17	despite	despite	IN
cord-356188-rwf78stz	162	18	higher	high	JJR
cord-356188-rwf78stz	162	19	viral	viral	JJ
cord-356188-rwf78stz	162	20	lung	lung	NN
cord-356188-rwf78stz	162	21	titers	titer	NNS
cord-356188-rwf78stz	162	22	,	,	,
cord-356188-rwf78stz	162	23	in	in	IN
cord-356188-rwf78stz	162	24	one	one	CD
cord-356188-rwf78stz	162	25	model	model	NN
cord-356188-rwf78stz	162	26	of	of	IN
cord-356188-rwf78stz	162	27	infection	infection	NN
cord-356188-rwf78stz	162	28	these	these	DT
cord-356188-rwf78stz	162	29	mice	mouse	NNS
cord-356188-rwf78stz	162	30	were	be	VBD
cord-356188-rwf78stz	162	31	protected	protect	VBN
cord-356188-rwf78stz	162	32	from	from	IN
cord-356188-rwf78stz	162	33	severe	severe	JJ
cord-356188-rwf78stz	162	34	pneumonitis	pneumonitis	NN
cord-356188-rwf78stz	162	35	[	[	-LRB-
cord-356188-rwf78stz	162	36	158	158	CD
cord-356188-rwf78stz	162	37	,	,	,
cord-356188-rwf78stz	162	38	159	159	CD
cord-356188-rwf78stz	162	39	]	]	-RRB-
cord-356188-rwf78stz	162	40	.	.	.
cord-356188-rwf78stz	163	1	In	in	IN
cord-356188-rwf78stz	163	2	the	the	DT
cord-356188-rwf78stz	163	3	lungs	lung	NNS
cord-356188-rwf78stz	163	4	,	,	,
cord-356188-rwf78stz	163	5	CCR2-mediated	CCR2-mediated	NNP
cord-356188-rwf78stz	163	6	recruit-	recruit-	NNP
cord-356188-rwf78stz	163	7	ment	ment	NNP
cord-356188-rwf78stz	163	8	of	of	IN
cord-356188-rwf78stz	163	9	TNF	TNF	NNP
cord-356188-rwf78stz	163	10	and	and	CC
cord-356188-rwf78stz	163	11	iNOS	inos	RB
cord-356188-rwf78stz	163	12	-	-	HYPH
cord-356188-rwf78stz	163	13	producing	produce	VBG
cord-356188-rwf78stz	163	14	DCs	dc	NNS
cord-356188-rwf78stz	163	15	augments	augment	VBZ
cord-356188-rwf78stz	163	16	influenzaspecific	influenzaspecific	NNP
cord-356188-rwf78stz	163	17	T	T	NNP
cord-356188-rwf78stz	163	18	cell	cell	NN
cord-356188-rwf78stz	163	19	responses	response	NNS
cord-356188-rwf78stz	163	20	[	[	-LRB-
cord-356188-rwf78stz	163	21	160	160	CD
cord-356188-rwf78stz	163	22	]	]	-RRB-
cord-356188-rwf78stz	163	23	.	.	.
cord-356188-rwf78stz	164	1	At	at	RB
cord-356188-rwf78stz	164	2	least	least	RBS
cord-356188-rwf78stz	164	3	one	one	CD
cord-356188-rwf78stz	164	4	murine	murine	JJ
cord-356188-rwf78stz	164	5	study	study	NN
cord-356188-rwf78stz	164	6	suggests	suggest	VBZ
cord-356188-rwf78stz	164	7	that	that	IN
cord-356188-rwf78stz	164	8	pregnant	pregnant	JJ
cord-356188-rwf78stz	164	9	mice	mouse	NNS
cord-356188-rwf78stz	164	10	have	have	VBP
cord-356188-rwf78stz	164	11	increased	increase	VBN
cord-356188-rwf78stz	164	12	infiltration	infiltration	NN
cord-356188-rwf78stz	164	13	of	of	IN
cord-356188-rwf78stz	164	14	neutrophils	neutrophil	NNS
cord-356188-rwf78stz	164	15	(	(	-LRB-
cord-356188-rwf78stz	165	1	CD11b	CD11b	NNPS
cord-356188-rwf78stz	165	2	high	high	JJ
cord-356188-rwf78stz	165	3	Ly6	ly6	NN
cord-356188-rwf78stz	165	4	G	g	NN
cord-356188-rwf78stz	165	5	high	high	JJ
cord-356188-rwf78stz	165	6	MHCII	MHCII	NNP
cord-356188-rwf78stz	165	7	Ϫ	Ϫ	NNP
cord-356188-rwf78stz	165	8	)	)	-RRB-
cord-356188-rwf78stz	165	9	and	and	CC
cord-356188-rwf78stz	165	10	macrophages	macrophage	NNS
cord-356188-rwf78stz	165	11	(	(	-LRB-
cord-356188-rwf78stz	166	1	CD11b	CD11b	NNPS
cord-356188-rwf78stz	166	2	high	high	JJ
cord-356188-rwf78stz	166	3	Ly6	ly6	NN
cord-356188-rwf78stz	166	4	G	G	NNP
cord-356188-rwf78stz	166	5	Ϫ	Ϫ	NNP
cord-356188-rwf78stz	166	6	MHCII	MHCII	NNP
cord-356188-rwf78stz	166	7	high	high	JJ
cord-356188-rwf78stz	166	8	)	)	-RRB-
cord-356188-rwf78stz	166	9	and	and	CC
cord-356188-rwf78stz	166	10	elevated	elevate	VBN
cord-356188-rwf78stz	166	11	,	,	,
cord-356188-rwf78stz	166	12	proinflammatory	proinflammatory	JJ
cord-356188-rwf78stz	166	13	cytokine	cytokine	NN
cord-356188-rwf78stz	166	14	levels	level	NNS
cord-356188-rwf78stz	166	15	,	,	,
cord-356188-rwf78stz	166	16	despite	despite	IN
cord-356188-rwf78stz	166	17	no	no	DT
cord-356188-rwf78stz	166	18	change	change	NN
cord-356188-rwf78stz	166	19	in	in	IN
cord-356188-rwf78stz	166	20	viral	viral	JJ
cord-356188-rwf78stz	166	21	titers	titer	NNS
cord-356188-rwf78stz	166	22	in	in	IN
cord-356188-rwf78stz	166	23	the	the	DT
cord-356188-rwf78stz	166	24	lungs	lung	NNS
cord-356188-rwf78stz	166	25	compared	compare	VBN
cord-356188-rwf78stz	166	26	with	with	IN
cord-356188-rwf78stz	166	27	nonpregnant	nonpregnant	JJ
cord-356188-rwf78stz	166	28	animals	animal	NNS
cord-356188-rwf78stz	166	29	[	[	-LRB-
cord-356188-rwf78stz	166	30	161	161	CD
cord-356188-rwf78stz	166	31	]	]	-RRB-
cord-356188-rwf78stz	166	32	.	.	.
cord-356188-rwf78stz	167	1	In	in	IN
cord-356188-rwf78stz	167	2	vitro	vitro	FW
cord-356188-rwf78stz	167	3	,	,	,
cord-356188-rwf78stz	167	4	influenza	influenza	NN
cord-356188-rwf78stz	167	5	infection	infection	NN
cord-356188-rwf78stz	167	6	of	of	IN
cord-356188-rwf78stz	167	7	murine	murine	JJ
cord-356188-rwf78stz	167	8	alveolar	alveolar	JJ
cord-356188-rwf78stz	167	9	epithelial	epithelial	JJ
cord-356188-rwf78stz	167	10	cells	cell	NNS
cord-356188-rwf78stz	167	11	resulted	result	VBD
cord-356188-rwf78stz	167	12	in	in	IN
cord-356188-rwf78stz	167	13	monocyte	monocyte	NNP
cord-356188-rwf78stz	167	14	production	production	NN
cord-356188-rwf78stz	167	15	of	of	IN
cord-356188-rwf78stz	167	16	MCP-1	MCP-1	NNP
cord-356188-rwf78stz	168	1	(	(	-LRB-
cord-356188-rwf78stz	168	2	CCL2	CCL2	NNP
cord-356188-rwf78stz	168	3	,	,	,
cord-356188-rwf78stz	168	4	the	the	DT
cord-356188-rwf78stz	168	5	ligand	ligand	NN
cord-356188-rwf78stz	168	6	for	for	IN
cord-356188-rwf78stz	168	7	CCR2	CCR2	NNP
cord-356188-rwf78stz	168	8	)	)	-RRB-
cord-356188-rwf78stz	168	9	and	and	CC
cord-356188-rwf78stz	168	10	RANTES	RANTES	NNPS
cord-356188-rwf78stz	168	11	,	,	,
cord-356188-rwf78stz	168	12	and	and	CC
cord-356188-rwf78stz	168	13	monocyte	monocyte	NNP
cord-356188-rwf78stz	168	14	migration	migration	NN
cord-356188-rwf78stz	168	15	was	be	VBD
cord-356188-rwf78stz	168	16	dependent	dependent	JJ
cord-356188-rwf78stz	168	17	on	on	IN
cord-356188-rwf78stz	168	18	CCR2	ccr2	JJ
cord-356188-rwf78stz	168	19	expression	expression	NN
cord-356188-rwf78stz	168	20	[	[	-LRB-
cord-356188-rwf78stz	168	21	162	162	CD
cord-356188-rwf78stz	168	22	]	]	-RRB-
cord-356188-rwf78stz	168	23	.	.	.
cord-356188-rwf78stz	169	1	Although	although	IN
cord-356188-rwf78stz	169	2	some	some	DT
cord-356188-rwf78stz	169	3	murine	murine	JJ
cord-356188-rwf78stz	169	4	models	model	NNS
cord-356188-rwf78stz	169	5	suggest	suggest	VBP
cord-356188-rwf78stz	169	6	that	that	IN
cord-356188-rwf78stz	169	7	neutrophils	neutrophil	NNS
cord-356188-rwf78stz	169	8	may	may	MD
cord-356188-rwf78stz	169	9	have	have	VB
cord-356188-rwf78stz	169	10	little	little	JJ
cord-356188-rwf78stz	169	11	role	role	NN
cord-356188-rwf78stz	169	12	in	in	IN
cord-356188-rwf78stz	169	13	mediating	mediate	VBG
cord-356188-rwf78stz	169	14	viral	viral	JJ
cord-356188-rwf78stz	169	15	clearance	clearance	NN
cord-356188-rwf78stz	169	16	[	[	-LRB-
cord-356188-rwf78stz	169	17	163	163	CD
cord-356188-rwf78stz	169	18	]	]	-RRB-
cord-356188-rwf78stz	169	19	,	,	,
cord-356188-rwf78stz	169	20	type	type	NN
cord-356188-rwf78stz	169	21	I	-PRON-	PRP
cord-356188-rwf78stz	169	22	interferon	interferon	VBD
cord-356188-rwf78stz	170	1	(	(	-LRB-
cord-356188-rwf78stz	170	2	IFN-	IFN-	NNP
cord-356188-rwf78stz	170	3	␣	␣	NNP
cord-356188-rwf78stz	170	4	/	/	SYM
cord-356188-rwf78stz	170	5	␤	␤	.
cord-356188-rwf78stz	171	1	)	)	-RRB-
cord-356188-rwf78stz	171	2	-dependent	-dependent	.
cord-356188-rwf78stz	172	1	generation	generation	NN
cord-356188-rwf78stz	172	2	of	of	IN
cord-356188-rwf78stz	172	3	Ly6C	ly6c	JJ
cord-356188-rwf78stz	172	4	hi	hi	UH
cord-356188-rwf78stz	172	5	monocytes	monocyte	NNS
cord-356188-rwf78stz	172	6	following	follow	VBG
cord-356188-rwf78stz	172	7	influenza	influenza	NN
cord-356188-rwf78stz	172	8	infection	infection	NN
cord-356188-rwf78stz	172	9	may	may	MD
cord-356188-rwf78stz	172	10	be	be	VB
cord-356188-rwf78stz	172	11	necessary	necessary	JJ
cord-356188-rwf78stz	172	12	to	to	TO
cord-356188-rwf78stz	172	13	limit	limit	VB
cord-356188-rwf78stz	172	14	excess	excess	JJ
cord-356188-rwf78stz	172	15	neutrophil	neutrophil	NN
cord-356188-rwf78stz	172	16	infiltration	infiltration	NN
cord-356188-rwf78stz	172	17	,	,	,
cord-356188-rwf78stz	172	18	preventing	prevent	VBG
cord-356188-rwf78stz	172	19	tissue	tissue	NN
cord-356188-rwf78stz	172	20	damage	damage	NN
cord-356188-rwf78stz	172	21	caused	cause	VBN
cord-356188-rwf78stz	172	22	by	by	IN
cord-356188-rwf78stz	172	23	uncontrolled	uncontrolled	JJ
cord-356188-rwf78stz	172	24	inflammation	inflammation	NN
cord-356188-rwf78stz	172	25	[	[	-LRB-
cord-356188-rwf78stz	172	26	164	164	CD
cord-356188-rwf78stz	172	27	]	]	-RRB-
cord-356188-rwf78stz	172	28	.	.	.
cord-356188-rwf78stz	173	1	In	in	IN
cord-356188-rwf78stz	173	2	addition	addition	NN
cord-356188-rwf78stz	173	3	,	,	,
cord-356188-rwf78stz	173	4	the	the	DT
cord-356188-rwf78stz	173	5	newly	newly	RB
cord-356188-rwf78stz	173	6	described	describe	VBN
cord-356188-rwf78stz	173	7	innate	innate	JJ
cord-356188-rwf78stz	173	8	lymphoid	lymphoid	JJ
cord-356188-rwf78stz	173	9	cells	cell	NNS
cord-356188-rwf78stz	173	10	have	have	VBP
cord-356188-rwf78stz	173	11	been	be	VBN
cord-356188-rwf78stz	173	12	implicated	implicate	VBN
cord-356188-rwf78stz	173	13	in	in	IN
cord-356188-rwf78stz	173	14	having	have	VBG
cord-356188-rwf78stz	173	15	a	a	DT
cord-356188-rwf78stz	173	16	role	role	NN
cord-356188-rwf78stz	173	17	in	in	IN
cord-356188-rwf78stz	173	18	airway	airway	NN
cord-356188-rwf78stz	173	19	integrity	integrity	NN
cord-356188-rwf78stz	173	20	following	follow	VBG
cord-356188-rwf78stz	173	21	influenza	influenza	NN
cord-356188-rwf78stz	173	22	infection	infection	NN
cord-356188-rwf78stz	173	23	[	[	-LRB-
cord-356188-rwf78stz	173	24	165	165	CD
cord-356188-rwf78stz	173	25	]	]	-RRB-
cord-356188-rwf78stz	173	26	.	.	.
cord-356188-rwf78stz	174	1	Thus	thus	RB
cord-356188-rwf78stz	174	2	,	,	,
cord-356188-rwf78stz	174	3	innate	innate	JJ
cord-356188-rwf78stz	174	4	immune	immune	JJ
cord-356188-rwf78stz	174	5	cells	cell	NNS
cord-356188-rwf78stz	174	6	,	,	,
cord-356188-rwf78stz	174	7	particularly	particularly	RB
cord-356188-rwf78stz	174	8	monocytes	monocyte	NNS
cord-356188-rwf78stz	174	9	,	,	,
cord-356188-rwf78stz	174	10	have	have	VBP
cord-356188-rwf78stz	174	11	at	at	RB
cord-356188-rwf78stz	174	12	least	least	RBS
cord-356188-rwf78stz	174	13	two	two	CD
cord-356188-rwf78stz	174	14	roles	role	NNS
cord-356188-rwf78stz	174	15	during	during	IN
cord-356188-rwf78stz	174	16	influenza	influenza	NN
cord-356188-rwf78stz	174	17	infection	infection	NN
cord-356188-rwf78stz	174	18	:	:	:
cord-356188-rwf78stz	174	19	to	to	TO
cord-356188-rwf78stz	174	20	boost	boost	VB
cord-356188-rwf78stz	174	21	the	the	DT
cord-356188-rwf78stz	174	22	innate	innate	JJ
cord-356188-rwf78stz	174	23	immune	immune	JJ
cord-356188-rwf78stz	174	24	response	response	NN
cord-356188-rwf78stz	174	25	by	by	IN
cord-356188-rwf78stz	174	26	producing	produce	VBG
cord-356188-rwf78stz	174	27	proinflammatory	proinflammatory	JJ
cord-356188-rwf78stz	174	28	cytokines	cytokine	NNS
cord-356188-rwf78stz	174	29	and	and	CC
cord-356188-rwf78stz	174	30	to	to	TO
cord-356188-rwf78stz	174	31	enhance	enhance	VB
cord-356188-rwf78stz	174	32	influenza	influenza	NN
cord-356188-rwf78stz	174	33	-	-	HYPH
cord-356188-rwf78stz	174	34	specific	specific	JJ
cord-356188-rwf78stz	174	35	T	t	NN
cord-356188-rwf78stz	174	36	cell	cell	NN
cord-356188-rwf78stz	174	37	responses	response	NNS
cord-356188-rwf78stz	174	38	.	.	.
cord-356188-rwf78stz	175	1	However	however	RB
cord-356188-rwf78stz	175	2	,	,	,
cord-356188-rwf78stz	175	3	the	the	DT
cord-356188-rwf78stz	175	4	lack	lack	NN
cord-356188-rwf78stz	175	5	of	of	IN
cord-356188-rwf78stz	175	6	clear	clear	JJ
cord-356188-rwf78stz	175	7	correspondence	correspondence	NN
cord-356188-rwf78stz	175	8	between	between	IN
cord-356188-rwf78stz	175	9	murine	murine	JJ
cord-356188-rwf78stz	175	10	and	and	CC
cord-356188-rwf78stz	175	11	human	human	JJ
cord-356188-rwf78stz	175	12	monocytic	monocytic	JJ
cord-356188-rwf78stz	175	13	subsets	subset	NNS
cord-356188-rwf78stz	175	14	has	have	VBZ
cord-356188-rwf78stz	175	15	made	make	VBN
cord-356188-rwf78stz	175	16	the	the	DT
cord-356188-rwf78stz	175	17	application	application	NN
cord-356188-rwf78stz	175	18	of	of	IN
cord-356188-rwf78stz	175	19	these	these	DT
cord-356188-rwf78stz	175	20	data	datum	NNS
cord-356188-rwf78stz	175	21	to	to	IN
cord-356188-rwf78stz	175	22	the	the	DT
cord-356188-rwf78stz	175	23	human	human	JJ
cord-356188-rwf78stz	175	24	situation	situation	NN
cord-356188-rwf78stz	175	25	difficult	difficult	JJ
cord-356188-rwf78stz	175	26	and	and	CC
cord-356188-rwf78stz	175	27	highlights	highlight	VBZ
cord-356188-rwf78stz	175	28	the	the	DT
cord-356188-rwf78stz	175	29	need	need	NN
cord-356188-rwf78stz	175	30	for	for	IN
cord-356188-rwf78stz	175	31	specific	specific	JJ
cord-356188-rwf78stz	175	32	studies	study	NNS
cord-356188-rwf78stz	175	33	focused	focus	VBN
cord-356188-rwf78stz	175	34	on	on	IN
cord-356188-rwf78stz	175	35	human	human	JJ
cord-356188-rwf78stz	175	36	innate	innate	JJ
cord-356188-rwf78stz	175	37	immune	immune	JJ
cord-356188-rwf78stz	175	38	responses	response	NNS
cord-356188-rwf78stz	175	39	.	.	.
cord-356188-rwf78stz	176	1	During	during	IN
cord-356188-rwf78stz	176	2	RSV	RSV	NNP
cord-356188-rwf78stz	176	3	and	and	CC
cord-356188-rwf78stz	176	4	influenza	influenza	NN
cord-356188-rwf78stz	176	5	infection	infection	NN
cord-356188-rwf78stz	176	6	of	of	IN
cord-356188-rwf78stz	176	7	infants	infant	NNS
cord-356188-rwf78stz	176	8	,	,	,
cord-356188-rwf78stz	176	9	neutrophils	neutrophil	NNS
cord-356188-rwf78stz	176	10	are	be	VBP
cord-356188-rwf78stz	176	11	recruited	recruit	VBN
cord-356188-rwf78stz	176	12	to	to	IN
cord-356188-rwf78stz	176	13	the	the	DT
cord-356188-rwf78stz	176	14	upper	upper	JJ
cord-356188-rwf78stz	176	15	and	and	CC
cord-356188-rwf78stz	176	16	lower	low	JJR
cord-356188-rwf78stz	176	17	airways	airway	NNS
cord-356188-rwf78stz	176	18	in	in	IN
cord-356188-rwf78stz	176	19	high	high	JJ
cord-356188-rwf78stz	176	20	numbers	number	NNS
cord-356188-rwf78stz	176	21	[	[	-LRB-
cord-356188-rwf78stz	176	22	103	103	CD
cord-356188-rwf78stz	176	23	,	,	,
cord-356188-rwf78stz	176	24	104	104	CD
cord-356188-rwf78stz	176	25	]	]	-RRB-
cord-356188-rwf78stz	176	26	,	,	,
cord-356188-rwf78stz	176	27	and	and	CC
cord-356188-rwf78stz	176	28	fatal	fatal	JJ
cord-356188-rwf78stz	176	29	cases	case	NNS
cord-356188-rwf78stz	176	30	during	during	IN
cord-356188-rwf78stz	176	31	the	the	DT
cord-356188-rwf78stz	176	32	A(H1N1)pdm09	A(H1N1)pdm09	NNP
cord-356188-rwf78stz	176	33	pandemic	pandemic	NN
cord-356188-rwf78stz	176	34	with	with	IN
cord-356188-rwf78stz	176	35	necrotizing	necrotize	VBG
cord-356188-rwf78stz	176	36	bronchiolitis	bronchiolitis	NN
cord-356188-rwf78stz	176	37	had	have	VBD
cord-356188-rwf78stz	176	38	more	more	JJR
cord-356188-rwf78stz	176	39	neutrophils	neutrophil	NNS
cord-356188-rwf78stz	176	40	within	within	IN
cord-356188-rwf78stz	176	41	the	the	DT
cord-356188-rwf78stz	176	42	lung	lung	NN
cord-356188-rwf78stz	176	43	infiltrate	infiltrate	VBP
cord-356188-rwf78stz	176	44	[	[	-LRB-
cord-356188-rwf78stz	176	45	33	33	CD
cord-356188-rwf78stz	176	46	]	]	-RRB-
cord-356188-rwf78stz	176	47	.	.	.
cord-356188-rwf78stz	177	1	The	the	DT
cord-356188-rwf78stz	177	2	neutrophil	neutrophil	NN
cord-356188-rwf78stz	177	3	chemoattractant	chemoattractant	NN
cord-356188-rwf78stz	177	4	IL-8	il-8	NN
cord-356188-rwf78stz	177	5	,	,	,
cord-356188-rwf78stz	177	6	produced	produce	VBN
cord-356188-rwf78stz	177	7	by	by	IN
cord-356188-rwf78stz	177	8	bronchial	bronchial	JJ
cord-356188-rwf78stz	177	9	epithelial	epithelial	JJ
cord-356188-rwf78stz	177	10	cells	cell	NNS
cord-356188-rwf78stz	177	11	,	,	,
cord-356188-rwf78stz	177	12	is	be	VBZ
cord-356188-rwf78stz	177	13	elevated	elevate	VBN
cord-356188-rwf78stz	177	14	early	early	RB
cord-356188-rwf78stz	177	15	during	during	IN
cord-356188-rwf78stz	177	16	experimental	experimental	JJ
cord-356188-rwf78stz	177	17	human	human	JJ
cord-356188-rwf78stz	177	18	influenza	influenza	NN
cord-356188-rwf78stz	177	19	infection	infection	NN
cord-356188-rwf78stz	177	20	[	[	-LRB-
cord-356188-rwf78stz	177	21	95	95	CD
cord-356188-rwf78stz	177	22	]	]	-RRB-
cord-356188-rwf78stz	177	23	and	and	CC
cord-356188-rwf78stz	177	24	is	be	VBZ
cord-356188-rwf78stz	177	25	increased	increase	VBN
cord-356188-rwf78stz	177	26	in	in	IN
cord-356188-rwf78stz	177	27	the	the	DT
cord-356188-rwf78stz	177	28	serum	serum	NN
cord-356188-rwf78stz	177	29	of	of	IN
cord-356188-rwf78stz	177	30	A	A	NNP
cord-356188-rwf78stz	177	31	/	/	SYM
cord-356188-rwf78stz	177	32	H5N1-infected	h5n1-infecte	VBN
cord-356188-rwf78stz	177	33	individuals	individual	NNS
cord-356188-rwf78stz	177	34	[	[	-LRB-
cord-356188-rwf78stz	177	35	96	96	CD
cord-356188-rwf78stz	177	36	]	]	-RRB-
cord-356188-rwf78stz	177	37	.	.	.
cord-356188-rwf78stz	178	1	Increased	increase	VBN
cord-356188-rwf78stz	178	2	IL-8	il-8	NN
cord-356188-rwf78stz	178	3	levels	level	NNS
cord-356188-rwf78stz	178	4	in	in	IN
cord-356188-rwf78stz	178	5	BALs	bal	NNS
cord-356188-rwf78stz	178	6	of	of	IN
cord-356188-rwf78stz	178	7	humans	human	NNS
cord-356188-rwf78stz	178	8	are	be	VBP
cord-356188-rwf78stz	178	9	associated	associate	VBN
cord-356188-rwf78stz	178	10	with	with	IN
cord-356188-rwf78stz	178	11	the	the	DT
cord-356188-rwf78stz	178	12	infiltration	infiltration	NN
cord-356188-rwf78stz	178	13	of	of	IN
cord-356188-rwf78stz	178	14	neutrophils	neutrophil	NNS
cord-356188-rwf78stz	178	15	and	and	CC
cord-356188-rwf78stz	178	16	may	may	MD
cord-356188-rwf78stz	178	17	have	have	VB
cord-356188-rwf78stz	178	18	a	a	DT
cord-356188-rwf78stz	178	19	role	role	NN
cord-356188-rwf78stz	178	20	in	in	IN
cord-356188-rwf78stz	178	21	neutrophil	neutrophil	NN
cord-356188-rwf78stz	178	22	-	-	HYPH
cord-356188-rwf78stz	178	23	mediated	mediate	VBN
cord-356188-rwf78stz	178	24	lung	lung	NN
cord-356188-rwf78stz	178	25	injury	injury	NN
cord-356188-rwf78stz	178	26	and	and	CC
cord-356188-rwf78stz	178	27	development	development	NN
cord-356188-rwf78stz	178	28	of	of	IN
cord-356188-rwf78stz	178	29	acute	acute	JJ
cord-356188-rwf78stz	178	30	respiratory	respiratory	JJ
cord-356188-rwf78stz	178	31	distress	distress	NN
cord-356188-rwf78stz	178	32	syndrome	syndrome	NN
cord-356188-rwf78stz	178	33	[	[	-LRB-
cord-356188-rwf78stz	178	34	97	97	CD
cord-356188-rwf78stz	178	35	]	]	-RRB-
cord-356188-rwf78stz	178	36	.	.	.
cord-356188-rwf78stz	179	1	Ex	Ex	NNP
cord-356188-rwf78stz	179	2	vivo	vivo	NN
cord-356188-rwf78stz	179	3	influenza	influenza	NN
cord-356188-rwf78stz	179	4	infection	infection	NN
cord-356188-rwf78stz	179	5	of	of	IN
cord-356188-rwf78stz	179	6	PB	PB	NNP
cord-356188-rwf78stz	179	7	-	-	HYPH
cord-356188-rwf78stz	179	8	MCs	MCs	NNP
cord-356188-rwf78stz	179	9	has	have	VBZ
cord-356188-rwf78stz	179	10	been	be	VBN
cord-356188-rwf78stz	179	11	shown	show	VBN
cord-356188-rwf78stz	179	12	to	to	TO
cord-356188-rwf78stz	179	13	induce	induce	VB
cord-356188-rwf78stz	179	14	apoptosis	apoptosis	NN
cord-356188-rwf78stz	179	15	in	in	IN
cord-356188-rwf78stz	179	16	neutrophils	neutrophil	NNS
cord-356188-rwf78stz	179	17	[	[	-LRB-
cord-356188-rwf78stz	179	18	166	166	CD
cord-356188-rwf78stz	179	19	]	]	-RRB-
cord-356188-rwf78stz	179	20	and	and	CC
cord-356188-rwf78stz	179	21	peripheral	peripheral	JJ
cord-356188-rwf78stz	179	22	blood	blood	NN
cord-356188-rwf78stz	179	23	monocytes	monocyte	NNS
cord-356188-rwf78stz	179	24	[	[	-LRB-
cord-356188-rwf78stz	179	25	167	167	CD
cord-356188-rwf78stz	179	26	]	]	-RRB-
cord-356188-rwf78stz	179	27	.	.	.
cord-356188-rwf78stz	180	1	Influenza	influenza	NN
cord-356188-rwf78stz	180	2	infection	infection	NN
cord-356188-rwf78stz	180	3	of	of	IN
cord-356188-rwf78stz	180	4	neutrophils	neutrophil	NNS
cord-356188-rwf78stz	180	5	resulted	result	VBD
cord-356188-rwf78stz	180	6	in	in	IN
cord-356188-rwf78stz	180	7	increased	increase	VBN
cord-356188-rwf78stz	180	8	hydrogen	hydrogen	NN
cord-356188-rwf78stz	180	9	peroxide	peroxide	NN
cord-356188-rwf78stz	180	10	production	production	NN
cord-356188-rwf78stz	180	11	,	,	,
cord-356188-rwf78stz	180	12	enhanced	enhance	VBN
cord-356188-rwf78stz	180	13	surface	surface	NN
cord-356188-rwf78stz	180	14	expression	expression	NN
cord-356188-rwf78stz	180	15	of	of	IN
cord-356188-rwf78stz	180	16	Fas	Fas	NNP
cord-356188-rwf78stz	180	17	antigen	antigen	NN
cord-356188-rwf78stz	180	18	and	and	CC
cord-356188-rwf78stz	180	19	FasL	FasL	NNP
cord-356188-rwf78stz	180	20	,	,	,
cord-356188-rwf78stz	180	21	and	and	CC
cord-356188-rwf78stz	180	22	secretion	secretion	NN
cord-356188-rwf78stz	180	23	of	of	IN
cord-356188-rwf78stz	180	24	FasL	FasL	NNP
cord-356188-rwf78stz	180	25	into	into	IN
cord-356188-rwf78stz	180	26	the	the	DT
cord-356188-rwf78stz	180	27	supernatant	supernatant	JJ
cord-356188-rwf78stz	180	28	[	[	-LRB-
cord-356188-rwf78stz	180	29	166	166	CD
cord-356188-rwf78stz	180	30	]	]	-RRB-
cord-356188-rwf78stz	180	31	.	.	.
cord-356188-rwf78stz	181	1	Interestingly	interestingly	RB
cord-356188-rwf78stz	181	2	,	,	,
cord-356188-rwf78stz	181	3	this	this	DT
cord-356188-rwf78stz	181	4	study	study	NN
cord-356188-rwf78stz	181	5	showed	show	VBD
cord-356188-rwf78stz	181	6	that	that	IN
cord-356188-rwf78stz	181	7	influenza	influenza	NN
cord-356188-rwf78stz	181	8	infection	infection	NN
cord-356188-rwf78stz	181	9	of	of	IN
cord-356188-rwf78stz	181	10	neutrophils	neutrophil	NNS
cord-356188-rwf78stz	181	11	resulted	result	VBD
cord-356188-rwf78stz	181	12	in	in	IN
cord-356188-rwf78stz	181	13	increased	increase	VBN
cord-356188-rwf78stz	181	14	internalization	internalization	NN
cord-356188-rwf78stz	181	15	of	of	IN
cord-356188-rwf78stz	181	16	Escherichia	Escherichia	NNP
cord-356188-rwf78stz	181	17	coli	coli	NNS
cord-356188-rwf78stz	181	18	,	,	,
cord-356188-rwf78stz	181	19	suggesting	suggest	VBG
cord-356188-rwf78stz	181	20	a	a	DT
cord-356188-rwf78stz	181	21	role	role	NN
cord-356188-rwf78stz	181	22	in	in	IN
cord-356188-rwf78stz	181	23	controlling	control	VBG
cord-356188-rwf78stz	181	24	bacterial	bacterial	JJ
cord-356188-rwf78stz	181	25	secondary	secondary	JJ
cord-356188-rwf78stz	181	26	infections	infection	NNS
cord-356188-rwf78stz	181	27	in	in	IN
cord-356188-rwf78stz	181	28	humans	human	NNS
cord-356188-rwf78stz	181	29	.	.	.
cord-356188-rwf78stz	182	1	Moreover	moreover	RB
cord-356188-rwf78stz	182	2	,	,	,
cord-356188-rwf78stz	182	3	standard	standard	JJ
cord-356188-rwf78stz	182	4	chemotaxis	chemotaxis	NN
cord-356188-rwf78stz	182	5	assays	assay	NNS
cord-356188-rwf78stz	182	6	during	during	IN
cord-356188-rwf78stz	182	7	experimental	experimental	JJ
cord-356188-rwf78stz	182	8	influenza	influenza	NN
cord-356188-rwf78stz	182	9	infection	infection	NN
cord-356188-rwf78stz	182	10	[	[	-LRB-
cord-356188-rwf78stz	182	11	168	168	CD
cord-356188-rwf78stz	182	12	-170	-170	NN
cord-356188-rwf78stz	182	13	]	]	-RRB-
cord-356188-rwf78stz	182	14	or	or	CC
cord-356188-rwf78stz	182	15	chemokine	chemokine	NN
cord-356188-rwf78stz	182	16	receptor	receptor	NN
cord-356188-rwf78stz	182	17	expression	expression	NN
cord-356188-rwf78stz	182	18	during	during	IN
cord-356188-rwf78stz	182	19	ex	ex	FW
cord-356188-rwf78stz	182	20	vivo	vivo	NN
cord-356188-rwf78stz	182	21	influenza	influenza	NN
cord-356188-rwf78stz	182	22	infection	infection	NN
cord-356188-rwf78stz	182	23	[	[	-LRB-
cord-356188-rwf78stz	182	24	105	105	CD
cord-356188-rwf78stz	182	25	]	]	-RRB-
cord-356188-rwf78stz	182	26	demonstrated	demonstrate	VBN
cord-356188-rwf78stz	182	27	impaired	impaired	JJ
cord-356188-rwf78stz	182	28	chemotaxis	chemotaxis	NN
cord-356188-rwf78stz	182	29	of	of	IN
cord-356188-rwf78stz	182	30	monocytes	monocyte	NNS
cord-356188-rwf78stz	182	31	and	and	CC
cord-356188-rwf78stz	182	32	granulocytes	granulocyte	NNS
cord-356188-rwf78stz	182	33	.	.	.
cord-356188-rwf78stz	183	1	Still	still	RB
cord-356188-rwf78stz	183	2	,	,	,
cord-356188-rwf78stz	183	3	although	although	IN
cord-356188-rwf78stz	183	4	all	all	DT
cord-356188-rwf78stz	183	5	of	of	IN
cord-356188-rwf78stz	183	6	these	these	DT
cord-356188-rwf78stz	183	7	studies	study	NNS
cord-356188-rwf78stz	183	8	suggest	suggest	VBP
cord-356188-rwf78stz	183	9	that	that	IN
cord-356188-rwf78stz	183	10	neutrophils	neutrophil	NNS
cord-356188-rwf78stz	183	11	can	can	MD
cord-356188-rwf78stz	183	12	be	be	VB
cord-356188-rwf78stz	183	13	regulated	regulate	VBN
cord-356188-rwf78stz	183	14	and	and	CC
cord-356188-rwf78stz	183	15	recruited	recruit	VBN
cord-356188-rwf78stz	183	16	during	during	IN
cord-356188-rwf78stz	183	17	human	human	JJ
cord-356188-rwf78stz	183	18	influenza	influenza	NN
cord-356188-rwf78stz	183	19	infection	infection	NN
cord-356188-rwf78stz	183	20	,	,	,
cord-356188-rwf78stz	183	21	the	the	DT
cord-356188-rwf78stz	183	22	specific	specific	JJ
cord-356188-rwf78stz	183	23	protective	protective	JJ
cord-356188-rwf78stz	183	24	and	and	CC
cord-356188-rwf78stz	183	25	pathological	pathological	JJ
cord-356188-rwf78stz	183	26	roles	role	NNS
cord-356188-rwf78stz	183	27	that	that	WDT
cord-356188-rwf78stz	183	28	they	-PRON-	PRP
cord-356188-rwf78stz	183	29	play	play	VBP
cord-356188-rwf78stz	183	30	in	in	IN
cord-356188-rwf78stz	183	31	vivo	vivo	NN
cord-356188-rwf78stz	183	32	remain	remain	VBP
cord-356188-rwf78stz	183	33	unclear	unclear	JJ
cord-356188-rwf78stz	183	34	.	.	.
cord-356188-rwf78stz	184	1	Nasopharygeal	nasopharygeal	JJ
cord-356188-rwf78stz	184	2	aspirates	aspirate	NNS
cord-356188-rwf78stz	184	3	of	of	IN
cord-356188-rwf78stz	184	4	infants	infant	NNS
cord-356188-rwf78stz	184	5	infected	infect	VBN
cord-356188-rwf78stz	184	6	with	with	IN
cord-356188-rwf78stz	184	7	influenza	influenza	NN
cord-356188-rwf78stz	184	8	have	have	VBP
cord-356188-rwf78stz	184	9	increased	increase	VBN
cord-356188-rwf78stz	184	10	levels	level	NNS
cord-356188-rwf78stz	184	11	of	of	IN
cord-356188-rwf78stz	184	12	proinflammatory	proinflammatory	JJ
cord-356188-rwf78stz	184	13	cytokines	cytokine	NNS
cord-356188-rwf78stz	184	14	such	such	JJ
cord-356188-rwf78stz	184	15	as	as	IN
cord-356188-rwf78stz	184	16	IL-6	IL-6	NNP
cord-356188-rwf78stz	184	17	,	,	,
cord-356188-rwf78stz	184	18	TNF-	TNF-	NNP
cord-356188-rwf78stz	184	19	␣	␣	NN
cord-356188-rwf78stz	184	20	,	,	,
cord-356188-rwf78stz	184	21	IL-10	IL-10	NNP
cord-356188-rwf78stz	184	22	,	,	,
cord-356188-rwf78stz	184	23	or	or	CC
cord-356188-rwf78stz	184	24	IFN-	IFN-	NNP
cord-356188-rwf78stz	184	25	␥	␥	NNPS
cord-356188-rwf78stz	184	26	compared	compare	VBN
cord-356188-rwf78stz	184	27	with	with	IN
cord-356188-rwf78stz	184	28	RSV	RSV	NNP
cord-356188-rwf78stz	184	29	-	-	HYPH
cord-356188-rwf78stz	184	30	or	or	CC
cord-356188-rwf78stz	184	31	human	human	JJ
cord-356188-rwf78stz	184	32	metapneumovirus	metapneumovirus	NN
cord-356188-rwf78stz	184	33	-	-	HYPH
cord-356188-rwf78stz	184	34	infected	infect	VBN
cord-356188-rwf78stz	184	35	infants	infant	NNS
cord-356188-rwf78stz	184	36	[	[	-LRB-
cord-356188-rwf78stz	184	37	98	98	CD
cord-356188-rwf78stz	184	38	-100	-100	NNS
cord-356188-rwf78stz	184	39	]	]	-RRB-
cord-356188-rwf78stz	184	40	,	,	,
cord-356188-rwf78stz	184	41	and	and	CC
cord-356188-rwf78stz	184	42	MIP-1	MIP-1	NNP
cord-356188-rwf78stz	184	43	␣	␣	CD
cord-356188-rwf78stz	184	44	levels	level	NNS
cord-356188-rwf78stz	184	45	are	be	VBP
cord-356188-rwf78stz	184	46	higher	high	JJR
cord-356188-rwf78stz	184	47	in	in	IN
cord-356188-rwf78stz	184	48	infants	infant	NNS
cord-356188-rwf78stz	184	49	with	with	IN
cord-356188-rwf78stz	184	50	more	more	RBR
cord-356188-rwf78stz	184	51	severe	severe	JJ
cord-356188-rwf78stz	184	52	influenza	influenza	NN
cord-356188-rwf78stz	184	53	infections	infection	NNS
cord-356188-rwf78stz	184	54	characterized	characterize	VBN
cord-356188-rwf78stz	184	55	by	by	IN
cord-356188-rwf78stz	184	56	hypoxic	hypoxic	JJ
cord-356188-rwf78stz	184	57	bronchiolitis	bronchiolitis	NN
cord-356188-rwf78stz	184	58	[	[	-LRB-
cord-356188-rwf78stz	184	59	101	101	CD
cord-356188-rwf78stz	184	60	]	]	-RRB-
cord-356188-rwf78stz	184	61	.	.	.
cord-356188-rwf78stz	185	1	Variability	variability	NN
cord-356188-rwf78stz	185	2	between	between	IN
cord-356188-rwf78stz	185	3	these	these	DT
cord-356188-rwf78stz	185	4	studies	study	NNS
cord-356188-rwf78stz	185	5	is	be	VBZ
cord-356188-rwf78stz	185	6	likely	likely	RB
cord-356188-rwf78stz	185	7	a	a	DT
cord-356188-rwf78stz	185	8	result	result	NN
cord-356188-rwf78stz	185	9	of	of	IN
cord-356188-rwf78stz	185	10	seasonal	seasonal	JJ
cord-356188-rwf78stz	185	11	differences	difference	NNS
cord-356188-rwf78stz	185	12	observed	observe	VBD
cord-356188-rwf78stz	185	13	year	year	NN
cord-356188-rwf78stz	185	14	-	-	HYPH
cord-356188-rwf78stz	185	15	to	to	IN
cord-356188-rwf78stz	185	16	-	-	HYPH
cord-356188-rwf78stz	185	17	year	year	NN
cord-356188-rwf78stz	185	18	.	.	.
cord-356188-rwf78stz	186	1	Individuals	individual	NNS
cord-356188-rwf78stz	186	2	infected	infect	VBN
cord-356188-rwf78stz	186	3	with	with	IN
cord-356188-rwf78stz	186	4	A	A	NNP
cord-356188-rwf78stz	186	5	/	/	SYM
cord-356188-rwf78stz	186	6	H5N1	H5N1	NNP
cord-356188-rwf78stz	186	7	have	have	VBP
cord-356188-rwf78stz	186	8	high	high	JJ
cord-356188-rwf78stz	186	9	viral	viral	JJ
cord-356188-rwf78stz	186	10	loads	load	NNS
cord-356188-rwf78stz	186	11	detected	detect	VBN
cord-356188-rwf78stz	186	12	within	within	IN
cord-356188-rwf78stz	186	13	respiratory	respiratory	JJ
cord-356188-rwf78stz	186	14	secretions	secretion	NNS
cord-356188-rwf78stz	186	15	and	and	CC
cord-356188-rwf78stz	186	16	peripheral	peripheral	JJ
cord-356188-rwf78stz	186	17	hypercytokinemia	hypercytokinemia	NN
cord-356188-rwf78stz	186	18	[	[	-LRB-
cord-356188-rwf78stz	186	19	96	96	CD
cord-356188-rwf78stz	186	20	,	,	,
cord-356188-rwf78stz	186	21	102	102	CD
cord-356188-rwf78stz	186	22	]	]	-RRB-
cord-356188-rwf78stz	186	23	.	.	.
cord-356188-rwf78stz	187	1	Severe	severe	JJ
cord-356188-rwf78stz	187	2	disease	disease	NN
cord-356188-rwf78stz	187	3	is	be	VBZ
cord-356188-rwf78stz	187	4	associated	associate	VBN
cord-356188-rwf78stz	187	5	with	with	IN
cord-356188-rwf78stz	187	6	macrophage	macrophage	NN
cord-356188-rwf78stz	187	7	infiltration	infiltration	NN
cord-356188-rwf78stz	187	8	into	into	IN
cord-356188-rwf78stz	187	9	the	the	DT
cord-356188-rwf78stz	187	10	lungs	lung	NNS
cord-356188-rwf78stz	187	11	,	,	,
cord-356188-rwf78stz	187	12	and	and	CC
cord-356188-rwf78stz	187	13	chemoattractants	chemoattractant	NNS
cord-356188-rwf78stz	187	14	of	of	IN
cord-356188-rwf78stz	187	15	monocytes	monocyte	NNS
cord-356188-rwf78stz	187	16	and	and	CC
cord-356188-rwf78stz	187	17	macrophages	macrophage	NNS
cord-356188-rwf78stz	187	18	,	,	,
cord-356188-rwf78stz	187	19	such	such	JJ
cord-356188-rwf78stz	187	20	as	as	IN
cord-356188-rwf78stz	187	21	IFN	IFN	NNP
cord-356188-rwf78stz	187	22	-	-	HYPH
cord-356188-rwf78stz	187	23	inducible	inducible	JJ
cord-356188-rwf78stz	187	24	protein	protein	NN
cord-356188-rwf78stz	187	25	10	10	CD
cord-356188-rwf78stz	187	26	(	(	-LRB-
cord-356188-rwf78stz	187	27	IP-10	IP-10	NNP
cord-356188-rwf78stz	187	28	)	)	-RRB-
cord-356188-rwf78stz	187	29	,	,	,
cord-356188-rwf78stz	187	30	monokine	monokine	NN
cord-356188-rwf78stz	187	31	induced	induce	VBN
cord-356188-rwf78stz	187	32	by	by	IN
cord-356188-rwf78stz	187	33	IFN-	IFN-	NNP
cord-356188-rwf78stz	187	34	␥	␥	NNP
cord-356188-rwf78stz	187	35	(	(	-LRB-
cord-356188-rwf78stz	187	36	MIG	MIG	NNP
cord-356188-rwf78stz	187	37	)	)	-RRB-
cord-356188-rwf78stz	187	38	,	,	,
cord-356188-rwf78stz	187	39	and	and	CC
cord-356188-rwf78stz	187	40	MCP-1	MCP-1	NNP
cord-356188-rwf78stz	187	41	,	,	,
cord-356188-rwf78stz	187	42	were	be	VBD
cord-356188-rwf78stz	187	43	found	find	VBN
cord-356188-rwf78stz	187	44	to	to	TO
cord-356188-rwf78stz	187	45	be	be	VB
cord-356188-rwf78stz	187	46	elevated	elevate	VBN
cord-356188-rwf78stz	187	47	in	in	IN
cord-356188-rwf78stz	187	48	the	the	DT
cord-356188-rwf78stz	187	49	serum	serum	NN
cord-356188-rwf78stz	187	50	of	of	IN
cord-356188-rwf78stz	187	51	influenza	influenza	NN
cord-356188-rwf78stz	187	52	-	-	HYPH
cord-356188-rwf78stz	187	53	infected	infect	VBN
cord-356188-rwf78stz	187	54	individuals	individual	NNS
cord-356188-rwf78stz	187	55	and	and	CC
cord-356188-rwf78stz	187	56	were	be	VBD
cord-356188-rwf78stz	187	57	highest	high	JJS
cord-356188-rwf78stz	187	58	in	in	IN
cord-356188-rwf78stz	187	59	those	those	DT
cord-356188-rwf78stz	187	60	infected	infect	VBN
cord-356188-rwf78stz	187	61	with	with	IN
cord-356188-rwf78stz	187	62	A	A	NNP
cord-356188-rwf78stz	187	63	/	/	SYM
cord-356188-rwf78stz	187	64	H5N1	H5N1	NNP
cord-356188-rwf78stz	187	65	[	[	-LRB-
cord-356188-rwf78stz	187	66	96	96	CD
cord-356188-rwf78stz	187	67	]	]	-RRB-
cord-356188-rwf78stz	187	68	.	.	.
cord-356188-rwf78stz	188	1	Therefore	therefore	RB
cord-356188-rwf78stz	188	2	,	,	,
cord-356188-rwf78stz	188	3	peripheral	peripheral	JJ
cord-356188-rwf78stz	188	4	(	(	-LRB-
cord-356188-rwf78stz	188	5	or	or	CC
cord-356188-rwf78stz	188	6	local	local	JJ
cord-356188-rwf78stz	188	7	)	)	-RRB-
cord-356188-rwf78stz	188	8	hypercytokinemia	hypercytokinemia	NN
cord-356188-rwf78stz	188	9	likely	likely	RB
cord-356188-rwf78stz	188	10	contributes	contribute	VBZ
cord-356188-rwf78stz	188	11	to	to	IN
cord-356188-rwf78stz	188	12	enhanced	enhance	VBN
cord-356188-rwf78stz	188	13	immunopathogenesis	immunopathogenesis	NN
cord-356188-rwf78stz	188	14	during	during	IN
cord-356188-rwf78stz	188	15	influenza	influenza	NN
cord-356188-rwf78stz	188	16	disease	disease	NNP
cord-356188-rwf78stz	188	17	.	.	.
cord-356188-rwf78stz	189	1	Although	although	IN
cord-356188-rwf78stz	189	2	there	there	EX
cord-356188-rwf78stz	189	3	is	be	VBZ
cord-356188-rwf78stz	189	4	no	no	DT
cord-356188-rwf78stz	189	5	difference	difference	NN
cord-356188-rwf78stz	189	6	in	in	IN
cord-356188-rwf78stz	189	7	the	the	DT
cord-356188-rwf78stz	189	8	duration	duration	NN
cord-356188-rwf78stz	189	9	of	of	IN
cord-356188-rwf78stz	189	10	viral	viral	JJ
cord-356188-rwf78stz	189	11	shedding	shed	VBG
cord-356188-rwf78stz	189	12	in	in	IN
cord-356188-rwf78stz	189	13	children	child	NNS
cord-356188-rwf78stz	189	14	hospitalized	hospitalize	VBN
cord-356188-rwf78stz	189	15	for	for	IN
cord-356188-rwf78stz	189	16	A	A	NNP
cord-356188-rwf78stz	189	17	/	/	SYM
cord-356188-rwf78stz	189	18	H1N1	H1N1	NNP
cord-356188-rwf78stz	189	19	or	or	CC
cord-356188-rwf78stz	189	20	A	A	NNP
cord-356188-rwf78stz	189	21	/	/	SYM
cord-356188-rwf78stz	189	22	H3N2	H3N2	NNP
cord-356188-rwf78stz	189	23	infections	infection	NNS
cord-356188-rwf78stz	189	24	compared	compare	VBN
cord-356188-rwf78stz	189	25	with	with	IN
cord-356188-rwf78stz	189	26	those	those	DT
cord-356188-rwf78stz	189	27	infected	infect	VBN
cord-356188-rwf78stz	189	28	with	with	IN
cord-356188-rwf78stz	189	29	influenza	influenza	NN
cord-356188-rwf78stz	189	30	B	b	NN
cord-356188-rwf78stz	189	31	virus	virus	NN
cord-356188-rwf78stz	189	32	,	,	,
cord-356188-rwf78stz	189	33	children	child	NNS
cord-356188-rwf78stz	189	34	with	with	IN
cord-356188-rwf78stz	189	35	influenza	influenza	NN
cord-356188-rwf78stz	189	36	A	a	DT
cord-356188-rwf78stz	189	37	exhibited	exhibit	VBN
cord-356188-rwf78stz	189	38	different	different	JJ
cord-356188-rwf78stz	189	39	serum	serum	NN
cord-356188-rwf78stz	189	40	cytokine	cytokine	NN
cord-356188-rwf78stz	189	41	profiles	profile	NNS
cord-356188-rwf78stz	189	42	.	.	.
cord-356188-rwf78stz	190	1	Serum	serum	NN
cord-356188-rwf78stz	190	2	IFN-	IFN-	NNP
cord-356188-rwf78stz	190	3	␥	␥	CD
cord-356188-rwf78stz	190	4	levels	level	NNS
cord-356188-rwf78stz	190	5	were	be	VBD
cord-356188-rwf78stz	190	6	similar	similar	JJ
cord-356188-rwf78stz	190	7	during	during	IN
cord-356188-rwf78stz	190	8	acute	acute	JJ
cord-356188-rwf78stz	190	9	-	-	HYPH
cord-356188-rwf78stz	190	10	phase	phase	NN
cord-356188-rwf78stz	190	11	infection	infection	NN
cord-356188-rwf78stz	190	12	[	[	-LRB-
cord-356188-rwf78stz	190	13	171	171	CD
cord-356188-rwf78stz	190	14	]	]	-RRB-
cord-356188-rwf78stz	190	15	,	,	,
cord-356188-rwf78stz	190	16	but	but	CC
cord-356188-rwf78stz	190	17	levels	level	NNS
cord-356188-rwf78stz	190	18	were	be	VBD
cord-356188-rwf78stz	190	19	increased	increase	VBN
cord-356188-rwf78stz	190	20	3	3	CD
cord-356188-rwf78stz	190	21	weeks	week	NNS
cord-356188-rwf78stz	190	22	following	follow	VBG
cord-356188-rwf78stz	190	23	influenza	influenza	NN
cord-356188-rwf78stz	190	24	B	b	NN
cord-356188-rwf78stz	190	25	infection	infection	NN
cord-356188-rwf78stz	190	26	compared	compare	VBN
cord-356188-rwf78stz	190	27	with	with	IN
cord-356188-rwf78stz	190	28	influenza	influenza	NN
cord-356188-rwf78stz	190	29	A	a	DT
cord-356188-rwf78stz	190	30	infection	infection	NN
cord-356188-rwf78stz	190	31	.	.	.
cord-356188-rwf78stz	191	1	Furthermore	furthermore	RB
cord-356188-rwf78stz	191	2	,	,	,
cord-356188-rwf78stz	191	3	serum	serum	NN
cord-356188-rwf78stz	191	4	IL-4	IL-4	NNP
cord-356188-rwf78stz	191	5	levels	level	NNS
cord-356188-rwf78stz	191	6	were	be	VBD
cord-356188-rwf78stz	191	7	significantly	significantly	RB
cord-356188-rwf78stz	191	8	higher	high	JJR
cord-356188-rwf78stz	191	9	during	during	IN
cord-356188-rwf78stz	191	10	the	the	DT
cord-356188-rwf78stz	191	11	acute	acute	JJ
cord-356188-rwf78stz	191	12	and	and	CC
cord-356188-rwf78stz	191	13	recovery	recovery	NN
cord-356188-rwf78stz	191	14	phases	phase	NNS
cord-356188-rwf78stz	191	15	of	of	IN
cord-356188-rwf78stz	191	16	influenza	influenza	NN
cord-356188-rwf78stz	191	17	A	a	DT
cord-356188-rwf78stz	191	18	infection	infection	NN
cord-356188-rwf78stz	191	19	.	.	.
cord-356188-rwf78stz	192	1	Influenza	influenza	NN
cord-356188-rwf78stz	192	2	strain	strain	NN
cord-356188-rwf78stz	192	3	differences	difference	NNS
cord-356188-rwf78stz	192	4	were	be	VBD
cord-356188-rwf78stz	192	5	also	also	RB
cord-356188-rwf78stz	192	6	observed	observe	VBN
cord-356188-rwf78stz	192	7	in	in	IN
cord-356188-rwf78stz	192	8	umbilical	umbilical	JJ
cord-356188-rwf78stz	192	9	cord	cord	NN
cord-356188-rwf78stz	192	10	blood	blood	NN
cord-356188-rwf78stz	192	11	lymphocytes	lymphocyte	NNS
cord-356188-rwf78stz	192	12	treated	treat	VBN
cord-356188-rwf78stz	192	13	with	with	IN
cord-356188-rwf78stz	192	14	UV	uv	NN
cord-356188-rwf78stz	192	15	-	-	HYPH
cord-356188-rwf78stz	192	16	inactivated	inactivate	VBN
cord-356188-rwf78stz	192	17	viruses	virus	NNS
cord-356188-rwf78stz	192	18	.	.	.
cord-356188-rwf78stz	193	1	UV	uv	NN
cord-356188-rwf78stz	193	2	-	-	HYPH
cord-356188-rwf78stz	193	3	inactivated	inactivate	VBN
cord-356188-rwf78stz	193	4	influenza	influenza	NN
cord-356188-rwf78stz	193	5	B	b	NN
cord-356188-rwf78stz	193	6	virus	virus	NN
cord-356188-rwf78stz	193	7	induced	induce	VBN
cord-356188-rwf78stz	193	8	less	less	JJR
cord-356188-rwf78stz	193	9	IFN-	IFN-	NNP
cord-356188-rwf78stz	193	10	␥	␥	ADD
cord-356188-rwf78stz	193	11	,	,	,
cord-356188-rwf78stz	193	12	IL-4	IL-4	NNP
cord-356188-rwf78stz	193	13	,	,	,
cord-356188-rwf78stz	193	14	or	or	CC
cord-356188-rwf78stz	193	15	IL-10	IL-10	NNP
cord-356188-rwf78stz	193	16	relative	relative	JJ
cord-356188-rwf78stz	193	17	to	to	IN
cord-356188-rwf78stz	193	18	UV	uv	NN
cord-356188-rwf78stz	193	19	-	-	HYPH
cord-356188-rwf78stz	193	20	inactivated	inactivate	VBN
cord-356188-rwf78stz	193	21	A	A	NNP
cord-356188-rwf78stz	193	22	/	/	SYM
cord-356188-rwf78stz	193	23	H1N1	H1N1	NNP
cord-356188-rwf78stz	193	24	,	,	,
cord-356188-rwf78stz	193	25	A	A	NNP
cord-356188-rwf78stz	193	26	/	/	SYM
cord-356188-rwf78stz	193	27	H3N2	H3N2	NNP
cord-356188-rwf78stz	193	28	,	,	,
cord-356188-rwf78stz	193	29	and	and	CC
cord-356188-rwf78stz	193	30	A	a	DT
cord-356188-rwf78stz	193	31	/	/	SYM
cord-356188-rwf78stz	193	32	H2N2	H2N2	NNP
cord-356188-rwf78stz	193	33	[	[	-LRB-
cord-356188-rwf78stz	193	34	172	172	CD
cord-356188-rwf78stz	193	35	]	]	-RRB-
cord-356188-rwf78stz	193	36	.	.	.
cord-356188-rwf78stz	194	1	Together	together	RB
cord-356188-rwf78stz	194	2	,	,	,
cord-356188-rwf78stz	194	3	these	these	DT
cord-356188-rwf78stz	194	4	data	datum	NNS
cord-356188-rwf78stz	194	5	strongly	strongly	RB
cord-356188-rwf78stz	194	6	suggest	suggest	VBP
cord-356188-rwf78stz	194	7	that	that	IN
cord-356188-rwf78stz	194	8	innate	innate	JJ
cord-356188-rwf78stz	194	9	cells	cell	NNS
cord-356188-rwf78stz	194	10	and	and	CC
cord-356188-rwf78stz	194	11	their	-PRON-	PRP$
cord-356188-rwf78stz	194	12	associated	associate	VBN
cord-356188-rwf78stz	194	13	responses	response	NNS
cord-356188-rwf78stz	194	14	have	have	VBP
cord-356188-rwf78stz	194	15	an	an	DT
cord-356188-rwf78stz	194	16	important	important	JJ
cord-356188-rwf78stz	194	17	role	role	NN
cord-356188-rwf78stz	194	18	in	in	IN
cord-356188-rwf78stz	194	19	influenza	influenza	NN
cord-356188-rwf78stz	194	20	disease	disease	NN
cord-356188-rwf78stz	194	21	manifestation	manifestation	NN
cord-356188-rwf78stz	194	22	,	,	,
cord-356188-rwf78stz	194	23	by	by	IN
cord-356188-rwf78stz	194	24	providing	provide	VBG
cord-356188-rwf78stz	194	25	protection	protection	NN
cord-356188-rwf78stz	194	26	and	and	CC
cord-356188-rwf78stz	194	27	by	by	IN
cord-356188-rwf78stz	194	28	contributing	contribute	VBG
cord-356188-rwf78stz	194	29	to	to	IN
cord-356188-rwf78stz	194	30	pathological	pathological	JJ
cord-356188-rwf78stz	194	31	outcomes	outcome	NNS
cord-356188-rwf78stz	194	32	.	.	.
cord-356188-rwf78stz	195	1	The	the	DT
cord-356188-rwf78stz	195	2	murine	murine	JJ
cord-356188-rwf78stz	195	3	studies	study	NNS
cord-356188-rwf78stz	195	4	cited	cite	VBN
cord-356188-rwf78stz	195	5	here	here	RB
cord-356188-rwf78stz	195	6	clearly	clearly	RB
cord-356188-rwf78stz	195	7	demonstrate	demonstrate	VBP
cord-356188-rwf78stz	195	8	that	that	IN
cord-356188-rwf78stz	195	9	the	the	DT
cord-356188-rwf78stz	195	10	local	local	JJ
cord-356188-rwf78stz	195	11	inflammatory	inflammatory	JJ
cord-356188-rwf78stz	195	12	environment	environment	NN
cord-356188-rwf78stz	195	13	can	can	MD
cord-356188-rwf78stz	195	14	be	be	VB
cord-356188-rwf78stz	195	15	dramatically	dramatically	RB
cord-356188-rwf78stz	195	16	different	different	JJ
cord-356188-rwf78stz	195	17	from	from	IN
cord-356188-rwf78stz	195	18	the	the	DT
cord-356188-rwf78stz	195	19	blood	blood	NN
cord-356188-rwf78stz	195	20	profile	profile	NN
cord-356188-rwf78stz	195	21	.	.	.
cord-356188-rwf78stz	196	1	The	the	DT
cord-356188-rwf78stz	196	2	vast	vast	JJ
cord-356188-rwf78stz	196	3	majority	majority	NN
cord-356188-rwf78stz	196	4	of	of	IN
cord-356188-rwf78stz	196	5	experimental	experimental	JJ
cord-356188-rwf78stz	196	6	data	datum	NNS
cord-356188-rwf78stz	196	7	in	in	IN
cord-356188-rwf78stz	196	8	humans	human	NNS
cord-356188-rwf78stz	196	9	is	be	VBZ
cord-356188-rwf78stz	196	10	restricted	restrict	VBN
cord-356188-rwf78stz	196	11	to	to	IN
cord-356188-rwf78stz	196	12	blood	blood	NN
cord-356188-rwf78stz	196	13	leukocytes	leukocyte	NNS
cord-356188-rwf78stz	196	14	,	,	,
cord-356188-rwf78stz	196	15	with	with	IN
cord-356188-rwf78stz	196	16	minimal	minimal	JJ
cord-356188-rwf78stz	196	17	emphasis	emphasis	NN
cord-356188-rwf78stz	196	18	placed	place	VBN
cord-356188-rwf78stz	196	19	on	on	IN
cord-356188-rwf78stz	196	20	sites	site	NNS
cord-356188-rwf78stz	196	21	of	of	IN
cord-356188-rwf78stz	196	22	infection	infection	NN
cord-356188-rwf78stz	196	23	.	.	.
cord-356188-rwf78stz	197	1	Further	further	RB
cord-356188-rwf78stz	197	2	,	,	,
cord-356188-rwf78stz	197	3	we	-PRON-	PRP
cord-356188-rwf78stz	197	4	lack	lack	VBP
cord-356188-rwf78stz	197	5	good	good	JJ
cord-356188-rwf78stz	197	6	,	,	,
cord-356188-rwf78stz	197	7	functional	functional	JJ
cord-356188-rwf78stz	197	8	analysis	analysis	NN
cord-356188-rwf78stz	197	9	of	of	IN
cord-356188-rwf78stz	197	10	these	these	DT
cord-356188-rwf78stz	197	11	cells	cell	NNS
cord-356188-rwf78stz	197	12	in	in	IN
cord-356188-rwf78stz	197	13	humans	human	NNS
cord-356188-rwf78stz	197	14	,	,	,
cord-356188-rwf78stz	197	15	and	and	CC
cord-356188-rwf78stz	197	16	most	most	JJS
cord-356188-rwf78stz	197	17	studies	study	NNS
cord-356188-rwf78stz	197	18	provide	provide	VBP
cord-356188-rwf78stz	197	19	correlational	correlational	JJ
cord-356188-rwf78stz	197	20	,	,	,
cord-356188-rwf78stz	197	21	cross	cross	JJ
cord-356188-rwf78stz	197	22	-	-	JJ
cord-356188-rwf78stz	197	23	sectional	sectional	JJ
cord-356188-rwf78stz	197	24	observations	observation	NNS
cord-356188-rwf78stz	197	25	.	.	.
cord-356188-rwf78stz	198	1	As	as	IN
cord-356188-rwf78stz	198	2	a	a	DT
cord-356188-rwf78stz	198	3	result	result	NN
cord-356188-rwf78stz	198	4	,	,	,
cord-356188-rwf78stz	198	5	there	there	EX
cord-356188-rwf78stz	198	6	is	be	VBZ
cord-356188-rwf78stz	198	7	a	a	DT
cord-356188-rwf78stz	198	8	significant	significant	JJ
cord-356188-rwf78stz	198	9	gap	gap	NN
cord-356188-rwf78stz	198	10	in	in	IN
cord-356188-rwf78stz	198	11	our	-PRON-	PRP$
cord-356188-rwf78stz	198	12	knowledge	knowledge	NN
cord-356188-rwf78stz	198	13	of	of	IN
cord-356188-rwf78stz	198	14	innate	innate	JJ
cord-356188-rwf78stz	198	15	immune	immune	JJ
cord-356188-rwf78stz	198	16	cells	cell	NNS
cord-356188-rwf78stz	198	17	in	in	IN
cord-356188-rwf78stz	198	18	affected	affected	JJ
cord-356188-rwf78stz	198	19	tissues	tissue	NNS
cord-356188-rwf78stz	198	20	.	.	.
cord-356188-rwf78stz	199	1	The	the	DT
cord-356188-rwf78stz	199	2	history	history	NN
cord-356188-rwf78stz	199	3	of	of	IN
cord-356188-rwf78stz	199	4	respiratory	respiratory	JJ
cord-356188-rwf78stz	199	5	virus	virus	NN
cord-356188-rwf78stz	199	6	challenge	challenge	NN
cord-356188-rwf78stz	199	7	studies	study	NNS
cord-356188-rwf78stz	199	8	dates	date	VBZ
cord-356188-rwf78stz	199	9	back	back	RB
cord-356188-rwf78stz	199	10	to	to	IN
cord-356188-rwf78stz	199	11	the	the	DT
cord-356188-rwf78stz	199	12	1918	1918	CD
cord-356188-rwf78stz	199	13	influenza	influenza	NN
cord-356188-rwf78stz	199	14	pandemic	pandemic	NN
cord-356188-rwf78stz	199	15	[	[	-LRB-
cord-356188-rwf78stz	199	16	173	173	CD
cord-356188-rwf78stz	199	17	]	]	-RRB-
cord-356188-rwf78stz	199	18	,	,	,
cord-356188-rwf78stz	199	19	and	and	CC
cord-356188-rwf78stz	199	20	early	early	JJ
cord-356188-rwf78stz	199	21	studies	study	NNS
cord-356188-rwf78stz	199	22	in	in	IN
cord-356188-rwf78stz	199	23	humans	human	NNS
cord-356188-rwf78stz	199	24	infected	infect	VBN
cord-356188-rwf78stz	199	25	with	with	IN
cord-356188-rwf78stz	199	26	influenza	influenza	NN
cord-356188-rwf78stz	199	27	identified	identify	VBD
cord-356188-rwf78stz	199	28	the	the	DT
cord-356188-rwf78stz	199	29	principal	principal	NN
cord-356188-rwf78stz	199	30	correlate	correlate	NN
cord-356188-rwf78stz	199	31	of	of	IN
cord-356188-rwf78stz	199	32	protection	protection	NN
cord-356188-rwf78stz	199	33	against	against	IN
cord-356188-rwf78stz	199	34	influenza	influenza	NN
cord-356188-rwf78stz	199	35	infection	infection	NN
cord-356188-rwf78stz	199	36	as	as	IN
cord-356188-rwf78stz	199	37	strain	strain	NN
cord-356188-rwf78stz	199	38	-	-	HYPH
cord-356188-rwf78stz	199	39	specific	specific	JJ
cord-356188-rwf78stz	199	40	,	,	,
cord-356188-rwf78stz	199	41	virus	virus	NN
cord-356188-rwf78stz	199	42	-	-	HYPH
cord-356188-rwf78stz	199	43	neutralizing	neutralize	VBG
cord-356188-rwf78stz	199	44	antibodies	antibody	NNS
cord-356188-rwf78stz	199	45	directed	direct	VBN
cord-356188-rwf78stz	199	46	against	against	IN
cord-356188-rwf78stz	199	47	the	the	DT
cord-356188-rwf78stz	199	48	HA	HA	NNP
cord-356188-rwf78stz	199	49	.	.	.
cord-356188-rwf78stz	200	1	These	these	DT
cord-356188-rwf78stz	200	2	studies	study	NNS
cord-356188-rwf78stz	200	3	(	(	-LRB-
cord-356188-rwf78stz	200	4	reviewed	review	VBN
cord-356188-rwf78stz	200	5	in	in	IN
cord-356188-rwf78stz	200	6	ref	ref	NN
cord-356188-rwf78stz	200	7	.	.	.
cord-356188-rwf78stz	201	1	[	[	-LRB-
cord-356188-rwf78stz	201	2	80	80	CD
cord-356188-rwf78stz	201	3	]	]	-RRB-
cord-356188-rwf78stz	201	4	)	)	-RRB-
cord-356188-rwf78stz	201	5	suggested	suggest	VBD
cord-356188-rwf78stz	201	6	that	that	IN
cord-356188-rwf78stz	201	7	the	the	DT
cord-356188-rwf78stz	201	8	presence	presence	NN
cord-356188-rwf78stz	201	9	of	of	IN
cord-356188-rwf78stz	201	10	serum	serum	NN
cord-356188-rwf78stz	201	11	antibody	antibody	NN
cord-356188-rwf78stz	201	12	is	be	VBZ
cord-356188-rwf78stz	201	13	associated	associate	VBN
cord-356188-rwf78stz	201	14	with	with	IN
cord-356188-rwf78stz	201	15	protection	protection	NN
cord-356188-rwf78stz	201	16	,	,	,
cord-356188-rwf78stz	201	17	as	as	IN
cord-356188-rwf78stz	201	18	illness	illness	NN
cord-356188-rwf78stz	201	19	is	be	VBZ
cord-356188-rwf78stz	201	20	less	less	RBR
cord-356188-rwf78stz	201	21	frequently	frequently	RB
cord-356188-rwf78stz	201	22	observed	observe	VBN
cord-356188-rwf78stz	201	23	in	in	IN
cord-356188-rwf78stz	201	24	those	those	DT
cord-356188-rwf78stz	201	25	people	people	NNS
cord-356188-rwf78stz	201	26	with	with	IN
cord-356188-rwf78stz	201	27	pre	pre	JJ
cord-356188-rwf78stz	201	28	-	-	JJ
cord-356188-rwf78stz	201	29	existing	existing	JJ
cord-356188-rwf78stz	201	30	nAb	nAb	NNPS
cord-356188-rwf78stz	201	31	[	[	-LRB-
cord-356188-rwf78stz	201	32	74	74	CD
cord-356188-rwf78stz	201	33	]	]	-RRB-
cord-356188-rwf78stz	201	34	.	.	.
cord-356188-rwf78stz	202	1	Subsequent	subsequent	JJ
cord-356188-rwf78stz	202	2	studies	study	NNS
cord-356188-rwf78stz	202	3	showed	show	VBD
cord-356188-rwf78stz	202	4	that	that	IN
cord-356188-rwf78stz	202	5	protection	protection	NN
cord-356188-rwf78stz	202	6	is	be	VBZ
cord-356188-rwf78stz	202	7	also	also	RB
cord-356188-rwf78stz	202	8	correlated	correlate	VBN
cord-356188-rwf78stz	202	9	with	with	IN
cord-356188-rwf78stz	202	10	the	the	DT
cord-356188-rwf78stz	202	11	development	development	NN
cord-356188-rwf78stz	202	12	of	of	IN
cord-356188-rwf78stz	202	13	serum	serum	NN
cord-356188-rwf78stz	202	14	and	and	CC
cord-356188-rwf78stz	202	15	mucosal	mucosal	JJ
cord-356188-rwf78stz	202	16	anti	anti	NNP
cord-356188-rwf78stz	202	17	-	-	JJ
cord-356188-rwf78stz	202	18	NA	na	JJ
cord-356188-rwf78stz	202	19	or	or	CC
cord-356188-rwf78stz	202	20	anti	anti	JJ
cord-356188-rwf78stz	202	21	-	-	JJ
cord-356188-rwf78stz	202	22	HA	HA	NNP
cord-356188-rwf78stz	202	23	IgG	IgG	NNP
cord-356188-rwf78stz	202	24	and	and	CC
cord-356188-rwf78stz	202	25	IgA	IgA	NNP
cord-356188-rwf78stz	202	26	[	[	-LRB-
cord-356188-rwf78stz	202	27	37	37	CD
cord-356188-rwf78stz	202	28	,	,	,
cord-356188-rwf78stz	202	29	47	47	CD
cord-356188-rwf78stz	202	30	,	,	,
cord-356188-rwf78stz	202	31	[	[	-LRB-
cord-356188-rwf78stz	202	32	75	75	CD
cord-356188-rwf78stz	202	33	]	]	-RRB-
cord-356188-rwf78stz	202	34	[	[	-LRB-
cord-356188-rwf78stz	202	35	76	76	CD
cord-356188-rwf78stz	202	36	]	]	-RRB-
cord-356188-rwf78stz	202	37	[	[	-LRB-
cord-356188-rwf78stz	202	38	77	77	CD
cord-356188-rwf78stz	202	39	]	]	-RRB-
cord-356188-rwf78stz	202	40	[	[	-LRB-
cord-356188-rwf78stz	202	41	78	78	CD
cord-356188-rwf78stz	202	42	]	]	-RRB-
cord-356188-rwf78stz	202	43	,	,	,
cord-356188-rwf78stz	202	44	but	but	CC
cord-356188-rwf78stz	202	45	this	this	DT
cord-356188-rwf78stz	202	46	protection	protection	NN
cord-356188-rwf78stz	202	47	can	can	MD
cord-356188-rwf78stz	202	48	be	be	VB
cord-356188-rwf78stz	202	49	incomplete	incomplete	JJ
cord-356188-rwf78stz	202	50	,	,	,
cord-356188-rwf78stz	202	51	as	as	IN
cord-356188-rwf78stz	202	52	individuals	individual	NNS
cord-356188-rwf78stz	202	53	with	with	IN
cord-356188-rwf78stz	202	54	detectable	detectable	JJ
cord-356188-rwf78stz	202	55	nAb	nAb	NNPS
cord-356188-rwf78stz	202	56	can	can	MD
cord-356188-rwf78stz	202	57	still	still	RB
cord-356188-rwf78stz	202	58	be	be	VB
cord-356188-rwf78stz	202	59	infected	infect	VBN
cord-356188-rwf78stz	202	60	[	[	-LRB-
cord-356188-rwf78stz	202	61	79	79	CD
cord-356188-rwf78stz	202	62	,	,	,
cord-356188-rwf78stz	202	63	174	174	CD
cord-356188-rwf78stz	202	64	]	]	-RRB-
cord-356188-rwf78stz	202	65	.	.	.
cord-356188-rwf78stz	203	1	Antibodies	antibody	NNS
cord-356188-rwf78stz	203	2	specific	specific	JJ
cord-356188-rwf78stz	203	3	for	for	IN
cord-356188-rwf78stz	203	4	the	the	DT
cord-356188-rwf78stz	203	5	NA	NA	NNP
cord-356188-rwf78stz	203	6	have	have	VBP
cord-356188-rwf78stz	203	7	been	be	VBN
cord-356188-rwf78stz	203	8	shown	show	VBN
cord-356188-rwf78stz	203	9	to	to	TO
cord-356188-rwf78stz	203	10	reduce	reduce	VB
cord-356188-rwf78stz	203	11	disease	disease	NN
cord-356188-rwf78stz	203	12	severity	severity	NN
cord-356188-rwf78stz	203	13	by	by	IN
cord-356188-rwf78stz	203	14	restricting	restrict	VBG
cord-356188-rwf78stz	203	15	virus	virus	NN
cord-356188-rwf78stz	203	16	release	release	NN
cord-356188-rwf78stz	203	17	from	from	IN
cord-356188-rwf78stz	203	18	infected	infected	JJ
cord-356188-rwf78stz	203	19	cells	cell	NNS
cord-356188-rwf78stz	203	20	and	and	CC
cord-356188-rwf78stz	203	21	enhancing	enhance	VBG
cord-356188-rwf78stz	203	22	viral	viral	JJ
cord-356188-rwf78stz	203	23	clearance	clearance	NN
cord-356188-rwf78stz	203	24	(	(	-LRB-
cord-356188-rwf78stz	203	25	reviewed	review	VBN
cord-356188-rwf78stz	203	26	in	in	IN
cord-356188-rwf78stz	203	27	ref	ref	NN
cord-356188-rwf78stz	203	28	.	.	.
cord-356188-rwf78stz	204	1	[	[	-LRB-
cord-356188-rwf78stz	204	2	175	175	CD
cord-356188-rwf78stz	204	3	]	]	-RRB-
cord-356188-rwf78stz	204	4	)	)	-RRB-
cord-356188-rwf78stz	204	5	.	.	.
cord-356188-rwf78stz	205	1	In	in	IN
cord-356188-rwf78stz	205	2	addition	addition	NN
cord-356188-rwf78stz	205	3	to	to	IN
cord-356188-rwf78stz	205	4	HA	HA	NNP
cord-356188-rwf78stz	205	5	and	and	CC
cord-356188-rwf78stz	205	6	NA	NA	NNP
cord-356188-rwf78stz	205	7	,	,	,
cord-356188-rwf78stz	205	8	antibodies	antibody	NNS
cord-356188-rwf78stz	205	9	are	be	VBP
cord-356188-rwf78stz	205	10	produced	produce	VBN
cord-356188-rwf78stz	205	11	to	to	IN
cord-356188-rwf78stz	205	12	NP	NP	NNP
cord-356188-rwf78stz	205	13	,	,	,
cord-356188-rwf78stz	205	14	matrix	matrix	NN
cord-356188-rwf78stz	205	15	M2	m2	NN
cord-356188-rwf78stz	205	16	protein	protein	NN
cord-356188-rwf78stz	205	17	,	,	,
cord-356188-rwf78stz	205	18	and	and	CC
cord-356188-rwf78stz	205	19	PB1-F2	PB1-F2	NNP
cord-356188-rwf78stz	205	20	[	[	-LRB-
cord-356188-rwf78stz	205	21	176	176	CD
cord-356188-rwf78stz	205	22	]	]	-RRB-
cord-356188-rwf78stz	205	23	,	,	,
cord-356188-rwf78stz	205	24	although	although	IN
cord-356188-rwf78stz	205	25	the	the	DT
cord-356188-rwf78stz	205	26	significance	significance	NN
cord-356188-rwf78stz	205	27	of	of	IN
cord-356188-rwf78stz	205	28	these	these	DT
cord-356188-rwf78stz	205	29	responses	response	NNS
cord-356188-rwf78stz	205	30	remains	remain	VBZ
cord-356188-rwf78stz	205	31	unclear	unclear	JJ
cord-356188-rwf78stz	205	32	.	.	.
cord-356188-rwf78stz	206	1	Of	of	RB
cord-356188-rwf78stz	206	2	course	course	RB
cord-356188-rwf78stz	206	3	,	,	,
cord-356188-rwf78stz	206	4	antigenic	antigenic	JJ
cord-356188-rwf78stz	206	5	shift	shift	NN
cord-356188-rwf78stz	206	6	and	and	CC
cord-356188-rwf78stz	206	7	antigenic	antigenic	JJ
cord-356188-rwf78stz	206	8	drift	drift	NN
cord-356188-rwf78stz	206	9	can	can	MD
cord-356188-rwf78stz	206	10	both	both	CC
cord-356188-rwf78stz	206	11	thwart	thwart	VB
cord-356188-rwf78stz	206	12	the	the	DT
cord-356188-rwf78stz	206	13	efficacy	efficacy	NN
cord-356188-rwf78stz	206	14	of	of	IN
cord-356188-rwf78stz	206	15	serological	serological	JJ
cord-356188-rwf78stz	206	16	memory	memory	NN
cord-356188-rwf78stz	206	17	.	.	.
cord-356188-rwf78stz	207	1	The	the	DT
cord-356188-rwf78stz	207	2	recent	recent	JJ
cord-356188-rwf78stz	207	3	circulation	circulation	NN
cord-356188-rwf78stz	207	4	of	of	IN
cord-356188-rwf78stz	207	5	A(H1N1)pdm09	A(H1N1)pdm09	NNP
cord-356188-rwf78stz	207	6	has	have	VBZ
cord-356188-rwf78stz	207	7	provided	provide	VBN
cord-356188-rwf78stz	207	8	a	a	DT
cord-356188-rwf78stz	207	9	modern	modern	JJ
cord-356188-rwf78stz	207	10	"	"	''
cord-356188-rwf78stz	207	11	experiment	experiment	NN
cord-356188-rwf78stz	207	12	of	of	IN
cord-356188-rwf78stz	207	13	nature	nature	NN
cord-356188-rwf78stz	207	14	"	"	''
cord-356188-rwf78stz	207	15	,	,	,
cord-356188-rwf78stz	207	16	demonstrating	demonstrate	VBG
cord-356188-rwf78stz	207	17	the	the	DT
cord-356188-rwf78stz	207	18	importance	importance	NN
cord-356188-rwf78stz	207	19	of	of	IN
cord-356188-rwf78stz	207	20	pre	pre	JJ
cord-356188-rwf78stz	207	21	-	-	JJ
cord-356188-rwf78stz	207	22	existing	existing	JJ
cord-356188-rwf78stz	207	23	antibody	antibody	NN
cord-356188-rwf78stz	207	24	from	from	IN
cord-356188-rwf78stz	207	25	prior	prior	JJ
cord-356188-rwf78stz	207	26	infection	infection	NN
cord-356188-rwf78stz	207	27	or	or	CC
cord-356188-rwf78stz	207	28	vaccination	vaccination	NN
cord-356188-rwf78stz	207	29	[	[	-LRB-
cord-356188-rwf78stz	207	30	81	81	CD
cord-356188-rwf78stz	207	31	]	]	-RRB-
cord-356188-rwf78stz	207	32	[	[	-LRB-
cord-356188-rwf78stz	207	33	82	82	CD
cord-356188-rwf78stz	207	34	]	]	-RRB-
cord-356188-rwf78stz	207	35	[	[	-LRB-
cord-356188-rwf78stz	207	36	83	83	CD
cord-356188-rwf78stz	207	37	]	]	-RRB-
cord-356188-rwf78stz	207	38	.	.	.
cord-356188-rwf78stz	208	1	Even	even	RB
cord-356188-rwf78stz	208	2	prior	prior	RB
cord-356188-rwf78stz	208	3	to	to	IN
cord-356188-rwf78stz	208	4	2009	2009	CD
cord-356188-rwf78stz	208	5	,	,	,
cord-356188-rwf78stz	208	6	it	-PRON-	PRP
cord-356188-rwf78stz	208	7	was	be	VBD
cord-356188-rwf78stz	208	8	well	well	RB
cord-356188-rwf78stz	208	9	-	-	HYPH
cord-356188-rwf78stz	208	10	recognized	recognize	VBN
cord-356188-rwf78stz	208	11	that	that	IN
cord-356188-rwf78stz	208	12	heterosubtypic	heterosubtypic	JJ
cord-356188-rwf78stz	208	13	immunity	immunity	NN
cord-356188-rwf78stz	208	14	has	have	VBZ
cord-356188-rwf78stz	208	15	a	a	DT
cord-356188-rwf78stz	208	16	large	large	JJ
cord-356188-rwf78stz	208	17	role	role	NN
cord-356188-rwf78stz	208	18	in	in	IN
cord-356188-rwf78stz	208	19	protection	protection	NN
cord-356188-rwf78stz	208	20	against	against	IN
cord-356188-rwf78stz	208	21	antigenic	antigenic	JJ
cord-356188-rwf78stz	208	22	variants	variant	NNS
cord-356188-rwf78stz	208	23	of	of	IN
cord-356188-rwf78stz	208	24	influenza	influenza	NN
cord-356188-rwf78stz	208	25	[	[	-LRB-
cord-356188-rwf78stz	208	26	84	84	CD
cord-356188-rwf78stz	208	27	,	,	,
cord-356188-rwf78stz	208	28	85	85	CD
cord-356188-rwf78stz	208	29	]	]	-RRB-
cord-356188-rwf78stz	208	30	,	,	,
cord-356188-rwf78stz	208	31	and	and	CC
cord-356188-rwf78stz	208	32	vaccine	vaccine	NN
cord-356188-rwf78stz	208	33	studies	study	NNS
cord-356188-rwf78stz	208	34	support	support	VBP
cord-356188-rwf78stz	208	35	the	the	DT
cord-356188-rwf78stz	208	36	idea	idea	NN
cord-356188-rwf78stz	208	37	that	that	IN
cord-356188-rwf78stz	208	38	cross	cross	JJ
cord-356188-rwf78stz	208	39	-	-	JJ
cord-356188-rwf78stz	208	40	protective	protective	JJ
cord-356188-rwf78stz	208	41	,	,	,
cord-356188-rwf78stz	208	42	adaptive	adaptive	JJ
cord-356188-rwf78stz	208	43	immune	immune	JJ
cord-356188-rwf78stz	208	44	responses	response	NNS
cord-356188-rwf78stz	208	45	occur	occur	VBP
cord-356188-rwf78stz	208	46	[	[	-LRB-
cord-356188-rwf78stz	208	47	86	86	CD
cord-356188-rwf78stz	208	48	]	]	-RRB-
cord-356188-rwf78stz	208	49	.	.	.
cord-356188-rwf78stz	209	1	Likewise	likewise	RB
cord-356188-rwf78stz	209	2	,	,	,
cord-356188-rwf78stz	209	3	neutralizing	neutralize	VBG
cord-356188-rwf78stz	209	4	polyclonal	polyclonal	JJ
cord-356188-rwf78stz	209	5	antibodies	antibody	NNS
cord-356188-rwf78stz	209	6	cross	cross	VBP
cord-356188-rwf78stz	209	7	-	-	JJ
cord-356188-rwf78stz	209	8	reactive	reactive	JJ
cord-356188-rwf78stz	209	9	against	against	IN
cord-356188-rwf78stz	209	10	H5	H5	NNP
cord-356188-rwf78stz	209	11	can	can	MD
cord-356188-rwf78stz	209	12	also	also	RB
cord-356188-rwf78stz	209	13	be	be	VB
cord-356188-rwf78stz	209	14	produced	produce	VBN
cord-356188-rwf78stz	209	15	in	in	IN
cord-356188-rwf78stz	209	16	individuals	individual	NNS
cord-356188-rwf78stz	209	17	vaccinated	vaccinate	VBN
cord-356188-rwf78stz	209	18	against	against	IN
cord-356188-rwf78stz	209	19	seasonal	seasonal	JJ
cord-356188-rwf78stz	209	20	influenza	influenza	NN
cord-356188-rwf78stz	209	21	,	,	,
cord-356188-rwf78stz	209	22	as	as	RB
cord-356188-rwf78stz	209	23	well	well	RB
cord-356188-rwf78stz	209	24	as	as	IN
cord-356188-rwf78stz	209	25	those	those	DT
cord-356188-rwf78stz	209	26	naturally	naturally	RB
cord-356188-rwf78stz	209	27	infected	infect	VBN
cord-356188-rwf78stz	209	28	with	with	IN
cord-356188-rwf78stz	209	29	A(H1N1)pdm09	A(H1N1)pdm09	NNP
cord-356188-rwf78stz	209	30	[	[	-LRB-
cord-356188-rwf78stz	209	31	87	87	CD
cord-356188-rwf78stz	209	32	,	,	,
cord-356188-rwf78stz	209	33	88	88	CD
cord-356188-rwf78stz	209	34	]	]	-RRB-
cord-356188-rwf78stz	209	35	.	.	.
cord-356188-rwf78stz	210	1	Compared	compare	VBN
cord-356188-rwf78stz	210	2	with	with	IN
cord-356188-rwf78stz	210	3	seasonal	seasonal	JJ
cord-356188-rwf78stz	210	4	influenza	influenza	NN
cord-356188-rwf78stz	210	5	infections	infection	NNS
cord-356188-rwf78stz	210	6	prior	prior	RB
cord-356188-rwf78stz	210	7	to	to	IN
cord-356188-rwf78stz	210	8	2009	2009	CD
cord-356188-rwf78stz	210	9	,	,	,
cord-356188-rwf78stz	210	10	ϳ31	ϳ31	CD
cord-356188-rwf78stz	210	11	%	%	NN
cord-356188-rwf78stz	210	12	of	of	IN
cord-356188-rwf78stz	210	13	B	B	NNP
cord-356188-rwf78stz	210	14	cell	cell	NN
cord-356188-rwf78stz	210	15	epitopes	epitope	NNS
cord-356188-rwf78stz	210	16	are	be	VBP
cord-356188-rwf78stz	210	17	conserved	conserve	VBN
cord-356188-rwf78stz	210	18	in	in	IN
cord-356188-rwf78stz	210	19	A(H1N1)pdm09	A(H1N1)pdm09	NNP
cord-356188-rwf78stz	210	20	,	,	,
cord-356188-rwf78stz	210	21	with	with	IN
cord-356188-rwf78stz	210	22	17	17	CD
cord-356188-rwf78stz	210	23	%	%	NN
cord-356188-rwf78stz	210	24	of	of	IN
cord-356188-rwf78stz	210	25	those	those	DT
cord-356188-rwf78stz	210	26	conserved	conserve	VBN
cord-356188-rwf78stz	210	27	within	within	IN
cord-356188-rwf78stz	210	28	the	the	DT
cord-356188-rwf78stz	210	29	surface	surface	NN
cord-356188-rwf78stz	210	30	viral	viral	JJ
cord-356188-rwf78stz	210	31	proteins	protein	NNS
cord-356188-rwf78stz	210	32	[	[	-LRB-
cord-356188-rwf78stz	210	33	177	177	CD
cord-356188-rwf78stz	210	34	]	]	-RRB-
cord-356188-rwf78stz	210	35	.	.	.
cord-356188-rwf78stz	211	1	The	the	DT
cord-356188-rwf78stz	211	2	HA	HA	NNP
cord-356188-rwf78stz	211	3	of	of	IN
cord-356188-rwf78stz	211	4	A(H1N1)pdm09	A(H1N1)pdm09	NNP
cord-356188-rwf78stz	211	5	contains	contain	VBZ
cord-356188-rwf78stz	211	6	sequences	sequence	NNS
cord-356188-rwf78stz	211	7	homologous	homologous	JJ
cord-356188-rwf78stz	211	8	with	with	IN
cord-356188-rwf78stz	211	9	that	that	DT
cord-356188-rwf78stz	211	10	of	of	IN
cord-356188-rwf78stz	211	11	A	A	NNP
cord-356188-rwf78stz	211	12	/	/	SYM
cord-356188-rwf78stz	211	13	H1N1	H1N1	NNP
cord-356188-rwf78stz	211	14	(	(	-LRB-
cord-356188-rwf78stz	211	15	1918	1918	CD
cord-356188-rwf78stz	211	16	)	)	-RRB-
cord-356188-rwf78stz	211	17	demonstrated	demonstrate	VBN
cord-356188-rwf78stz	211	18	by	by	IN
cord-356188-rwf78stz	211	19	the	the	DT
cord-356188-rwf78stz	211	20	A	A	NNP
cord-356188-rwf78stz	211	21	/	/	SYM
cord-356188-rwf78stz	211	22	H1N1	H1N1	NNP
cord-356188-rwf78stz	211	23	(	(	-LRB-
cord-356188-rwf78stz	211	24	1918	1918	CD
cord-356188-rwf78stz	211	25	)	)	-RRB-
cord-356188-rwf78stz	212	1	mAb	mAb	NNS
cord-356188-rwf78stz	212	2	2D1	2d1	CD
cord-356188-rwf78stz	212	3	,	,	,
cord-356188-rwf78stz	212	4	which	which	WDT
cord-356188-rwf78stz	212	5	binds	bind	VBZ
cord-356188-rwf78stz	212	6	to	to	IN
cord-356188-rwf78stz	212	7	the	the	DT
cord-356188-rwf78stz	212	8	Sa	Sa	NNP
cord-356188-rwf78stz	212	9	antigenic	antigenic	JJ
cord-356188-rwf78stz	212	10	site	site	NN
cord-356188-rwf78stz	212	11	of	of	IN
cord-356188-rwf78stz	212	12	the	the	DT
cord-356188-rwf78stz	212	13	HA	HA	NNP
cord-356188-rwf78stz	212	14	[	[	-LRB-
cord-356188-rwf78stz	212	15	89	89	CD
cord-356188-rwf78stz	212	16	]	]	-RRB-
cord-356188-rwf78stz	212	17	.	.	.
cord-356188-rwf78stz	213	1	Furthermore	furthermore	RB
cord-356188-rwf78stz	213	2	,	,	,
cord-356188-rwf78stz	213	3	this	this	DT
cord-356188-rwf78stz	213	4	particular	particular	JJ
cord-356188-rwf78stz	213	5	antibody	antibody	NN
cord-356188-rwf78stz	213	6	can	can	MD
cord-356188-rwf78stz	213	7	neutralize	neutralize	VB
cord-356188-rwf78stz	213	8	HA	HA	NNP
cord-356188-rwf78stz	213	9	activity	activity	NN
cord-356188-rwf78stz	213	10	in	in	IN
cord-356188-rwf78stz	213	11	vitro	vitro	FW
cord-356188-rwf78stz	213	12	,	,	,
cord-356188-rwf78stz	213	13	and	and	CC
cord-356188-rwf78stz	213	14	mAb	mAb	NNS
cord-356188-rwf78stz	213	15	-	-	HYPH
cord-356188-rwf78stz	213	16	treated	treat	VBN
cord-356188-rwf78stz	213	17	mice	mouse	NNS
cord-356188-rwf78stz	213	18	show	show	VBP
cord-356188-rwf78stz	213	19	reduced	reduce	VBN
cord-356188-rwf78stz	213	20	viral	viral	JJ
cord-356188-rwf78stz	213	21	titers	titer	NNS
cord-356188-rwf78stz	213	22	when	when	WRB
cord-356188-rwf78stz	213	23	challenged	challenge	VBN
cord-356188-rwf78stz	213	24	with	with	IN
cord-356188-rwf78stz	213	25	A(H1N1)pdm09	A(H1N1)pdm09	NNP
cord-356188-rwf78stz	213	26	[	[	-LRB-
cord-356188-rwf78stz	213	27	90	90	CD
cord-356188-rwf78stz	213	28	]	]	-RRB-
cord-356188-rwf78stz	213	29	.	.	.
cord-356188-rwf78stz	214	1	Most	Most	JJS
cord-356188-rwf78stz	214	2	neutralizing	neutralize	VBG
cord-356188-rwf78stz	214	3	antibodies	antibody	NNS
cord-356188-rwf78stz	214	4	bind	bind	VBP
cord-356188-rwf78stz	214	5	to	to	IN
cord-356188-rwf78stz	214	6	the	the	DT
cord-356188-rwf78stz	214	7	exposed	expose	VBN
cord-356188-rwf78stz	214	8	regions	region	NNS
cord-356188-rwf78stz	214	9	of	of	IN
cord-356188-rwf78stz	214	10	the	the	DT
cord-356188-rwf78stz	214	11	HA	HA	NNP
cord-356188-rwf78stz	214	12	that	that	WDT
cord-356188-rwf78stz	214	13	surround	surround	VBP
cord-356188-rwf78stz	214	14	the	the	DT
cord-356188-rwf78stz	214	15	receptor	receptor	NN
cord-356188-rwf78stz	214	16	-	-	HYPH
cord-356188-rwf78stz	214	17	binding	bind	VBG
cord-356188-rwf78stz	214	18	site	site	NN
cord-356188-rwf78stz	214	19	and	and	CC
cord-356188-rwf78stz	214	20	interfere	interfere	VB
cord-356188-rwf78stz	214	21	with	with	IN
cord-356188-rwf78stz	214	22	attachment	attachment	NN
cord-356188-rwf78stz	214	23	to	to	IN
cord-356188-rwf78stz	214	24	sialic	sialic	JJ
cord-356188-rwf78stz	214	25	acids	acid	NNS
cord-356188-rwf78stz	214	26	on	on	IN
cord-356188-rwf78stz	214	27	the	the	DT
cord-356188-rwf78stz	214	28	cell	cell	NN
cord-356188-rwf78stz	214	29	surface	surface	NN
cord-356188-rwf78stz	214	30	.	.	.
cord-356188-rwf78stz	215	1	Therefore	therefore	RB
cord-356188-rwf78stz	215	2	,	,	,
cord-356188-rwf78stz	215	3	generation	generation	NN
cord-356188-rwf78stz	215	4	of	of	IN
cord-356188-rwf78stz	215	5	crossprotective	crossprotective	JJ
cord-356188-rwf78stz	215	6	neutralizing	neutralize	VBG
cord-356188-rwf78stz	215	7	antibodies	antibody	NNS
cord-356188-rwf78stz	215	8	is	be	VBZ
cord-356188-rwf78stz	215	9	elusive	elusive	JJ
cord-356188-rwf78stz	215	10	,	,	,
cord-356188-rwf78stz	215	11	as	as	IN
cord-356188-rwf78stz	215	12	the	the	DT
cord-356188-rwf78stz	215	13	external	external	JJ
cord-356188-rwf78stz	215	14	viral	viral	JJ
cord-356188-rwf78stz	215	15	proteins	protein	NNS
cord-356188-rwf78stz	215	16	are	be	VBP
cord-356188-rwf78stz	215	17	most	most	RBS
cord-356188-rwf78stz	215	18	exposed	expose	VBN
cord-356188-rwf78stz	215	19	to	to	IN
cord-356188-rwf78stz	215	20	immune	immune	JJ
cord-356188-rwf78stz	215	21	pressure	pressure	NN
cord-356188-rwf78stz	215	22	,	,	,
cord-356188-rwf78stz	215	23	but	but	CC
cord-356188-rwf78stz	215	24	universal	universal	JJ
cord-356188-rwf78stz	215	25	immunization	immunization	NN
cord-356188-rwf78stz	215	26	against	against	IN
cord-356188-rwf78stz	215	27	conserved	conserve	VBN
cord-356188-rwf78stz	215	28	HA	HA	NNP
cord-356188-rwf78stz	215	29	stalk	stalk	NN
cord-356188-rwf78stz	215	30	and	and	CC
cord-356188-rwf78stz	215	31	M2e	m2e	NN
cord-356188-rwf78stz	215	32	domains	domain	NNS
cord-356188-rwf78stz	215	33	is	be	VBZ
cord-356188-rwf78stz	215	34	promising	promise	VBG
cord-356188-rwf78stz	215	35	[	[	-LRB-
cord-356188-rwf78stz	215	36	71	71	CD
cord-356188-rwf78stz	215	37	]	]	-RRB-
cord-356188-rwf78stz	215	38	[	[	-LRB-
cord-356188-rwf78stz	215	39	72	72	CD
cord-356188-rwf78stz	215	40	]	]	-RRB-
cord-356188-rwf78stz	215	41	[	[	-LRB-
cord-356188-rwf78stz	215	42	73	73	CD
cord-356188-rwf78stz	215	43	]	]	-RRB-
cord-356188-rwf78stz	215	44	.	.	.
cord-356188-rwf78stz	216	1	Human	human	JJ
cord-356188-rwf78stz	216	2	PBMCs	pbmc	NNS
cord-356188-rwf78stz	216	3	include	include	VBP
cord-356188-rwf78stz	216	4	at	at	RB
cord-356188-rwf78stz	216	5	least	least	RBS
cord-356188-rwf78stz	216	6	three	three	CD
cord-356188-rwf78stz	216	7	major	major	JJ
cord-356188-rwf78stz	216	8	subsets	subset	NNS
cord-356188-rwf78stz	216	9	of	of	IN
cord-356188-rwf78stz	216	10	DCs	dc	NNS
cord-356188-rwf78stz	216	11	:	:	:
cord-356188-rwf78stz	217	1	CD141	CD141	``
cord-356188-rwf78stz	217	2	ϩ	ϩ	NNP
cord-356188-rwf78stz	217	3	mDCs	mdcs	NN
cord-356188-rwf78stz	217	4	,	,	,
cord-356188-rwf78stz	217	5	CD1c	CD1c	NNP
cord-356188-rwf78stz	217	6	ϩ	ϩ	NNP
cord-356188-rwf78stz	217	7	mDCs	mdcs	XX
cord-356188-rwf78stz	217	8	,	,	.
cord-356188-rwf78stz	218	1	and	and	CC
cord-356188-rwf78stz	218	2	pDCs	pDCs	NNP
cord-356188-rwf78stz	218	3	(	(	-LRB-
cord-356188-rwf78stz	218	4	reviewed	review	VBN
cord-356188-rwf78stz	218	5	in	in	IN
cord-356188-rwf78stz	218	6	ref	ref	NN
cord-356188-rwf78stz	218	7	.	.	.
cord-356188-rwf78stz	219	1	[	[	-LRB-
cord-356188-rwf78stz	219	2	178	178	CD
cord-356188-rwf78stz	219	3	]	]	-RRB-
cord-356188-rwf78stz	219	4	)	)	-RRB-
cord-356188-rwf78stz	219	5	.	.	.
cord-356188-rwf78stz	220	1	DCs	DCs	NNP
cord-356188-rwf78stz	220	2	process	process	NN
cord-356188-rwf78stz	220	3	and	and	CC
cord-356188-rwf78stz	220	4	present	present	JJ
cord-356188-rwf78stz	220	5	antigen	antigen	NN
cord-356188-rwf78stz	220	6	to	to	IN
cord-356188-rwf78stz	220	7	T	t	NN
cord-356188-rwf78stz	220	8	cells	cell	NNS
cord-356188-rwf78stz	220	9	and	and	CC
cord-356188-rwf78stz	220	10	therefore	therefore	RB
cord-356188-rwf78stz	220	11	have	have	VBP
cord-356188-rwf78stz	220	12	an	an	DT
cord-356188-rwf78stz	220	13	important	important	JJ
cord-356188-rwf78stz	220	14	role	role	NN
cord-356188-rwf78stz	220	15	in	in	IN
cord-356188-rwf78stz	220	16	regulating	regulate	VBG
cord-356188-rwf78stz	220	17	the	the	DT
cord-356188-rwf78stz	220	18	adaptive	adaptive	JJ
cord-356188-rwf78stz	220	19	immune	immune	JJ
cord-356188-rwf78stz	220	20	response	response	NN
cord-356188-rwf78stz	220	21	.	.	.
cord-356188-rwf78stz	221	1	Depending	depend	VBG
cord-356188-rwf78stz	221	2	on	on	IN
cord-356188-rwf78stz	221	3	the	the	DT
cord-356188-rwf78stz	221	4	local	local	JJ
cord-356188-rwf78stz	221	5	cytokine	cytokine	NN
cord-356188-rwf78stz	221	6	milieu	milieu	NN
cord-356188-rwf78stz	221	7	,	,	,
cord-356188-rwf78stz	221	8	mDCs	mDCs	NNP
cord-356188-rwf78stz	221	9	can	can	MD
cord-356188-rwf78stz	221	10	differentiate	differentiate	VB
cord-356188-rwf78stz	221	11	into	into	IN
cord-356188-rwf78stz	221	12	macrophages	macrophage	NNS
cord-356188-rwf78stz	221	13	or	or	CC
cord-356188-rwf78stz	221	14	tissue	tissue	NN
cord-356188-rwf78stz	221	15	-	-	HYPH
cord-356188-rwf78stz	221	16	specific	specific	JJ
cord-356188-rwf78stz	221	17	DCs	dc	NNS
cord-356188-rwf78stz	221	18	(	(	-LRB-
cord-356188-rwf78stz	221	19	i.e.	i.e.	FW
cord-356188-rwf78stz	221	20	,	,	,
cord-356188-rwf78stz	221	21	epithelial	epithelial	JJ
cord-356188-rwf78stz	221	22	Langerhans	Langerhans	NNP
cord-356188-rwf78stz	221	23	cells	cell	NNS
cord-356188-rwf78stz	221	24	or	or	CC
cord-356188-rwf78stz	221	25	interstitial	interstitial	JJ
cord-356188-rwf78stz	221	26	DCs	dc	NNS
cord-356188-rwf78stz	221	27	)	)	-RRB-
cord-356188-rwf78stz	221	28	.	.	.
cord-356188-rwf78stz	222	1	As	as	IN
cord-356188-rwf78stz	222	2	influenza	influenza	NN
cord-356188-rwf78stz	222	3	primarily	primarily	RB
cord-356188-rwf78stz	222	4	infects	infect	VBZ
cord-356188-rwf78stz	222	5	epithelial	epithelial	JJ
cord-356188-rwf78stz	222	6	cells	cell	NNS
cord-356188-rwf78stz	222	7	lining	line	VBG
cord-356188-rwf78stz	222	8	the	the	DT
cord-356188-rwf78stz	222	9	respiratory	respiratory	JJ
cord-356188-rwf78stz	222	10	tract	tract	NN
cord-356188-rwf78stz	222	11	,	,	,
cord-356188-rwf78stz	222	12	lung	lung	NN
cord-356188-rwf78stz	222	13	-	-	HYPH
cord-356188-rwf78stz	222	14	resident	resident	NN
cord-356188-rwf78stz	222	15	DCs	dc	NNS
cord-356188-rwf78stz	222	16	and	and	CC
cord-356188-rwf78stz	222	17	macrophages	macrophage	NNS
cord-356188-rwf78stz	222	18	are	be	VBP
cord-356188-rwf78stz	222	19	particularly	particularly	RB
cord-356188-rwf78stz	222	20	important	important	JJ
cord-356188-rwf78stz	222	21	for	for	IN
cord-356188-rwf78stz	222	22	efficient	efficient	JJ
cord-356188-rwf78stz	222	23	development	development	NN
cord-356188-rwf78stz	222	24	of	of	IN
cord-356188-rwf78stz	222	25	an	an	DT
cord-356188-rwf78stz	222	26	adaptive	adaptive	JJ
cord-356188-rwf78stz	222	27	immune	immune	JJ
cord-356188-rwf78stz	222	28	response	response	NN
cord-356188-rwf78stz	222	29	.	.	.
cord-356188-rwf78stz	223	1	Once	once	RB
cord-356188-rwf78stz	223	2	activated	activate	VBN
cord-356188-rwf78stz	223	3	,	,	,
cord-356188-rwf78stz	223	4	mDCs	mdcs	JJ
cord-356188-rwf78stz	223	5	function	function	NN
cord-356188-rwf78stz	223	6	as	as	IN
cord-356188-rwf78stz	223	7	APCs	apc	NNS
cord-356188-rwf78stz	223	8	to	to	TO
cord-356188-rwf78stz	223	9	activate	activate	VB
cord-356188-rwf78stz	223	10	T	t	NN
cord-356188-rwf78stz	223	11	cells	cell	NNS
cord-356188-rwf78stz	223	12	;	;	:
cord-356188-rwf78stz	223	13	on	on	IN
cord-356188-rwf78stz	223	14	the	the	DT
cord-356188-rwf78stz	223	15	other	other	JJ
cord-356188-rwf78stz	223	16	hand	hand	NN
cord-356188-rwf78stz	223	17	,	,	,
cord-356188-rwf78stz	223	18	pDCs	pDCs	NNP
cord-356188-rwf78stz	223	19	are	be	VBP
cord-356188-rwf78stz	223	20	major	major	JJ
cord-356188-rwf78stz	223	21	producers	producer	NNS
cord-356188-rwf78stz	223	22	of	of	IN
cord-356188-rwf78stz	223	23	type	type	NN
cord-356188-rwf78stz	224	1	I	-PRON-	PRP
cord-356188-rwf78stz	224	2	IFN	IFN	NNP
cord-356188-rwf78stz	224	3	upon	upon	IN
cord-356188-rwf78stz	224	4	TLR	TLR	NNP
cord-356188-rwf78stz	224	5	activation	activation	NN
cord-356188-rwf78stz	224	6	.	.	.
cord-356188-rwf78stz	225	1	In	in	IN
cord-356188-rwf78stz	225	2	response	response	NN
cord-356188-rwf78stz	225	3	to	to	IN
cord-356188-rwf78stz	225	4	influenza	influenza	NN
cord-356188-rwf78stz	225	5	infection	infection	NN
cord-356188-rwf78stz	225	6	in	in	IN
cord-356188-rwf78stz	225	7	vitro	vitro	FW
cord-356188-rwf78stz	225	8	,	,	,
cord-356188-rwf78stz	225	9	human	human	JJ
cord-356188-rwf78stz	225	10	DCs	dc	NNS
cord-356188-rwf78stz	225	11	and	and	CC
cord-356188-rwf78stz	225	12	macrophages	macrophage	NNS
cord-356188-rwf78stz	225	13	undergo	undergo	VBP
cord-356188-rwf78stz	225	14	maturation	maturation	NN
cord-356188-rwf78stz	225	15	,	,	,
cord-356188-rwf78stz	225	16	secreting	secrete	VBG
cord-356188-rwf78stz	225	17	type	type	NN
cord-356188-rwf78stz	226	1	I	-PRON-	PRP
cord-356188-rwf78stz	226	2	IFN	IFN	NNP
cord-356188-rwf78stz	226	3	and	and	CC
cord-356188-rwf78stz	226	4	inducing	induce	VBG
cord-356188-rwf78stz	226	5	T	t	NN
cord-356188-rwf78stz	226	6	cell	cell	NN
cord-356188-rwf78stz	226	7	proliferation	proliferation	NN
cord-356188-rwf78stz	226	8	and	and	CC
cord-356188-rwf78stz	226	9	IFN-	IFN-	NNP
cord-356188-rwf78stz	226	10	␥	␥	CD
cord-356188-rwf78stz	226	11	production	production	NN
cord-356188-rwf78stz	226	12	[	[	-LRB-
cord-356188-rwf78stz	226	13	179	179	CD
cord-356188-rwf78stz	226	14	-181	-181	NN
cord-356188-rwf78stz	226	15	]	]	-RRB-
cord-356188-rwf78stz	226	16	.	.	.
cord-356188-rwf78stz	227	1	Cellular	cellular	JJ
cord-356188-rwf78stz	227	2	immune	immune	JJ
cord-356188-rwf78stz	227	3	responses	response	NNS
cord-356188-rwf78stz	227	4	(	(	-LRB-
cord-356188-rwf78stz	227	5	CD8	CD8	NNP
cord-356188-rwf78stz	227	6	ϩ	ϩ	NNP
cord-356188-rwf78stz	227	7	CTLs	CTLs	NNP
cord-356188-rwf78stz	227	8	and	and	CC
cord-356188-rwf78stz	227	9	CD4	CD4	NNP
cord-356188-rwf78stz	227	10	ϩ	ϩ	.
cord-356188-rwf78stz	227	11	Th	Th	NNP
cord-356188-rwf78stz	227	12	cells	cell	NNS
cord-356188-rwf78stz	227	13	)	)	-RRB-
cord-356188-rwf78stz	227	14	are	be	VBP
cord-356188-rwf78stz	227	15	important	important	JJ
cord-356188-rwf78stz	227	16	for	for	IN
cord-356188-rwf78stz	227	17	virus	virus	NN
cord-356188-rwf78stz	227	18	clearance	clearance	NN
cord-356188-rwf78stz	227	19	in	in	IN
cord-356188-rwf78stz	227	20	murine	murine	JJ
cord-356188-rwf78stz	227	21	models	model	NNS
cord-356188-rwf78stz	227	22	of	of	IN
cord-356188-rwf78stz	227	23	influenza	influenza	NN
cord-356188-rwf78stz	227	24	infection	infection	NN
cord-356188-rwf78stz	227	25	,	,	,
cord-356188-rwf78stz	227	26	with	with	IN
cord-356188-rwf78stz	227	27	CD4	CD4	NNP
cord-356188-rwf78stz	227	28	ϩ	ϩ	NNP
cord-356188-rwf78stz	227	29	and	and	CC
cord-356188-rwf78stz	227	30	CD8	CD8	NNP
cord-356188-rwf78stz	227	31	ϩ	ϩ	NNP
cord-356188-rwf78stz	227	32	T	T	NNP
cord-356188-rwf78stz	227	33	cell	cell	NN
cord-356188-rwf78stz	227	34	-	-	HYPH
cord-356188-rwf78stz	227	35	depleted	deplete	VBN
cord-356188-rwf78stz	227	36	mice	mouse	NNS
cord-356188-rwf78stz	227	37	displaying	display	VBG
cord-356188-rwf78stz	227	38	delayed	delay	VBN
cord-356188-rwf78stz	227	39	viral	viral	JJ
cord-356188-rwf78stz	227	40	clearance	clearance	NN
cord-356188-rwf78stz	227	41	.	.	.
cord-356188-rwf78stz	228	1	The	the	DT
cord-356188-rwf78stz	228	2	relevance	relevance	NN
cord-356188-rwf78stz	228	3	of	of	IN
cord-356188-rwf78stz	228	4	these	these	DT
cord-356188-rwf78stz	228	5	observations	observation	NNS
cord-356188-rwf78stz	228	6	remains	remain	VBZ
cord-356188-rwf78stz	228	7	somewhat	somewhat	RB
cord-356188-rwf78stz	228	8	controversial	controversial	JJ
cord-356188-rwf78stz	228	9	in	in	IN
cord-356188-rwf78stz	228	10	humans	human	NNS
cord-356188-rwf78stz	228	11	.	.	.
cord-356188-rwf78stz	229	1	Regard	regard	NN
cord-356188-rwf78stz	229	2	-	-	HYPH
cord-356188-rwf78stz	229	3	less	less	JJR
cord-356188-rwf78stz	229	4	,	,	,
cord-356188-rwf78stz	229	5	as	as	IN
cord-356188-rwf78stz	229	6	in	in	IN
cord-356188-rwf78stz	229	7	mice	mouse	NNS
cord-356188-rwf78stz	229	8	,	,	,
cord-356188-rwf78stz	229	9	the	the	DT
cord-356188-rwf78stz	229	10	human	human	JJ
cord-356188-rwf78stz	229	11	lung	lung	NN
cord-356188-rwf78stz	229	12	contains	contain	VBZ
cord-356188-rwf78stz	229	13	resident	resident	JJ
cord-356188-rwf78stz	229	14	respiratory	respiratory	JJ
cord-356188-rwf78stz	229	15	virus	virus	NN
cord-356188-rwf78stz	229	16	-	-	HYPH
cord-356188-rwf78stz	229	17	specific	specific	JJ
cord-356188-rwf78stz	229	18	CD8	CD8	NNP
cord-356188-rwf78stz	229	19	ϩ	ϩ	WDT
cord-356188-rwf78stz	229	20	memory	memory	NN
cord-356188-rwf78stz	229	21	T	T	NNP
cord-356188-rwf78stz	229	22	cells	cell	NNS
cord-356188-rwf78stz	229	23	[	[	-LRB-
cord-356188-rwf78stz	229	24	182	182	CD
cord-356188-rwf78stz	229	25	]	]	-RRB-
cord-356188-rwf78stz	229	26	,	,	,
cord-356188-rwf78stz	229	27	which	which	WDT
cord-356188-rwf78stz	229	28	can	can	MD
cord-356188-rwf78stz	229	29	effectively	effectively	RB
cord-356188-rwf78stz	229	30	kill	kill	VB
cord-356188-rwf78stz	229	31	virus	virus	NN
cord-356188-rwf78stz	229	32	-	-	HYPH
cord-356188-rwf78stz	229	33	infected	infect	VBN
cord-356188-rwf78stz	229	34	cells	cell	NNS
cord-356188-rwf78stz	229	35	.	.	.
cord-356188-rwf78stz	230	1	Human	human	JJ
cord-356188-rwf78stz	230	2	CD8	CD8	NNP
cord-356188-rwf78stz	230	3	ϩ	ϩ	WDT
cord-356188-rwf78stz	230	4	T	T	NNP
cord-356188-rwf78stz	230	5	cells	cell	NNS
cord-356188-rwf78stz	230	6	recognize	recognize	VBP
cord-356188-rwf78stz	230	7	antigen	antigen	NN
cord-356188-rwf78stz	230	8	in	in	IN
cord-356188-rwf78stz	230	9	the	the	DT
cord-356188-rwf78stz	230	10	context	context	NN
cord-356188-rwf78stz	230	11	of	of	IN
cord-356188-rwf78stz	230	12	surface	surface	NN
cord-356188-rwf78stz	230	13	HLA	HLA	NNP
cord-356188-rwf78stz	230	14	molecules	molecule	NNS
cord-356188-rwf78stz	230	15	and	and	CC
cord-356188-rwf78stz	230	16	generally	generally	RB
cord-356188-rwf78stz	230	17	recognize	recognize	VBP
cord-356188-rwf78stz	230	18	a	a	DT
cord-356188-rwf78stz	230	19	broad	broad	JJ
cord-356188-rwf78stz	230	20	range	range	NN
cord-356188-rwf78stz	230	21	of	of	IN
cord-356188-rwf78stz	230	22	influenza	influenza	NN
cord-356188-rwf78stz	230	23	epitopes	epitope	NNS
cord-356188-rwf78stz	230	24	,	,	,
cord-356188-rwf78stz	230	25	including	include	VBG
cord-356188-rwf78stz	230	26	those	those	DT
cord-356188-rwf78stz	230	27	from	from	IN
cord-356188-rwf78stz	230	28	structural	structural	JJ
cord-356188-rwf78stz	230	29	and	and	CC
cord-356188-rwf78stz	230	30	nonstructural	nonstructural	JJ
cord-356188-rwf78stz	230	31	influenza	influenza	NN
cord-356188-rwf78stz	230	32	proteins	protein	NNS
cord-356188-rwf78stz	230	33	[	[	-LRB-
cord-356188-rwf78stz	230	34	121	121	CD
cord-356188-rwf78stz	230	35	]	]	-RRB-
cord-356188-rwf78stz	230	36	.	.	.
cord-356188-rwf78stz	231	1	Approximately	approximately	RB
cord-356188-rwf78stz	231	2	41	41	CD
cord-356188-rwf78stz	231	3	%	%	NN
cord-356188-rwf78stz	231	4	of	of	IN
cord-356188-rwf78stz	231	5	CD4	CD4	NNP
cord-356188-rwf78stz	231	6	ϩ	ϩ	NNP
cord-356188-rwf78stz	231	7	and	and	CC
cord-356188-rwf78stz	231	8	69	69	CD
cord-356188-rwf78stz	231	9	%	%	NN
cord-356188-rwf78stz	231	10	of	of	IN
cord-356188-rwf78stz	231	11	CD8	CD8	NNP
cord-356188-rwf78stz	231	12	ϩ	ϩ	NNP
cord-356188-rwf78stz	231	13	T	T	NNP
cord-356188-rwf78stz	231	14	cell	cell	NN
cord-356188-rwf78stz	231	15	epitopes	epitope	NNS
cord-356188-rwf78stz	231	16	are	be	VBP
cord-356188-rwf78stz	231	17	conserved	conserve	VBN
cord-356188-rwf78stz	231	18	in	in	IN
cord-356188-rwf78stz	231	19	A(H1N1)pdm09	A(H1N1)pdm09	NNP
cord-356188-rwf78stz	231	20	from	from	IN
cord-356188-rwf78stz	231	21	the	the	DT
cord-356188-rwf78stz	231	22	prior	prior	JJ
cord-356188-rwf78stz	231	23	circulating	circulate	VBG
cord-356188-rwf78stz	231	24	seasonal	seasonal	JJ
cord-356188-rwf78stz	231	25	H1N1	H1N1	NNP
cord-356188-rwf78stz	231	26	[	[	-LRB-
cord-356188-rwf78stz	231	27	177	177	CD
cord-356188-rwf78stz	231	28	]	]	-RRB-
cord-356188-rwf78stz	231	29	.	.	.
cord-356188-rwf78stz	232	1	Furthermore	furthermore	RB
cord-356188-rwf78stz	232	2	,	,	,
cord-356188-rwf78stz	232	3	CD8	CD8	NNP
cord-356188-rwf78stz	232	4	ϩ	ϩ	NNP
cord-356188-rwf78stz	232	5	intraepithelial	intraepithelial	JJ
cord-356188-rwf78stz	232	6	T	T	NNP
cord-356188-rwf78stz	232	7	cells	cell	NNS
cord-356188-rwf78stz	232	8	can	can	MD
cord-356188-rwf78stz	232	9	mount	mount	VB
cord-356188-rwf78stz	232	10	fast	fast	JJ
cord-356188-rwf78stz	232	11	and	and	CC
cord-356188-rwf78stz	232	12	efficient	efficient	JJ
cord-356188-rwf78stz	232	13	recall	recall	NN
cord-356188-rwf78stz	232	14	responses	response	NNS
cord-356188-rwf78stz	232	15	upon	upon	IN
cord-356188-rwf78stz	232	16	viral	viral	JJ
cord-356188-rwf78stz	232	17	infection	infection	NN
cord-356188-rwf78stz	232	18	[	[	-LRB-
cord-356188-rwf78stz	232	19	183	183	CD
cord-356188-rwf78stz	232	20	]	]	-RRB-
cord-356188-rwf78stz	232	21	,	,	,
cord-356188-rwf78stz	232	22	and	and	CC
cord-356188-rwf78stz	233	1	immunization	immunization	NN
cord-356188-rwf78stz	233	2	studies	study	NNS
cord-356188-rwf78stz	233	3	in	in	IN
cord-356188-rwf78stz	233	4	humans	human	NNS
cord-356188-rwf78stz	233	5	have	have	VBP
cord-356188-rwf78stz	233	6	shown	show	VBN
cord-356188-rwf78stz	233	7	that	that	IN
cord-356188-rwf78stz	233	8	T	t	NN
cord-356188-rwf78stz	233	9	cell	cell	NN
cord-356188-rwf78stz	233	10	responses	response	NNS
cord-356188-rwf78stz	233	11	peak	peak	VBP
cord-356188-rwf78stz	233	12	within	within	IN
cord-356188-rwf78stz	233	13	1	1	CD
cord-356188-rwf78stz	233	14	week	week	NN
cord-356188-rwf78stz	233	15	after	after	IN
cord-356188-rwf78stz	233	16	symptom	symptom	NN
cord-356188-rwf78stz	233	17	onset	onset	NN
cord-356188-rwf78stz	233	18	[	[	-LRB-
cord-356188-rwf78stz	233	19	174	174	CD
cord-356188-rwf78stz	233	20	]	]	-RRB-
cord-356188-rwf78stz	233	21	.	.	.
cord-356188-rwf78stz	234	1	In	in	IN
cord-356188-rwf78stz	234	2	terms	term	NNS
cord-356188-rwf78stz	234	3	of	of	IN
cord-356188-rwf78stz	234	4	pandemic	pandemic	NN
cord-356188-rwf78stz	234	5	viruses	virus	NNS
cord-356188-rwf78stz	234	6	,	,	,
cord-356188-rwf78stz	234	7	individuals	individual	NNS
cord-356188-rwf78stz	234	8	infected	infect	VBN
cord-356188-rwf78stz	234	9	with	with	IN
cord-356188-rwf78stz	234	10	A(H1N1)pdm09	A(H1N1)pdm09	NNP
cord-356188-rwf78stz	234	11	were	be	VBD
cord-356188-rwf78stz	234	12	shown	show	VBN
cord-356188-rwf78stz	234	13	to	to	TO
cord-356188-rwf78stz	234	14	have	have	VB
cord-356188-rwf78stz	234	15	rapid	rapid	JJ
cord-356188-rwf78stz	234	16	,	,	,
cord-356188-rwf78stz	234	17	virus	virus	NN
cord-356188-rwf78stz	234	18	-	-	HYPH
cord-356188-rwf78stz	234	19	specific	specific	JJ
cord-356188-rwf78stz	234	20	CD8	CD8	NNP
cord-356188-rwf78stz	234	21	ϩ	ϩ	WDT
cord-356188-rwf78stz	234	22	T	T	NNP
cord-356188-rwf78stz	234	23	cell	cell	NN
cord-356188-rwf78stz	234	24	recall	recall	NN
cord-356188-rwf78stz	234	25	responses	response	NNS
cord-356188-rwf78stz	234	26	early	early	RB
cord-356188-rwf78stz	234	27	during	during	IN
cord-356188-rwf78stz	234	28	infection	infection	NN
cord-356188-rwf78stz	234	29	,	,	,
cord-356188-rwf78stz	234	30	but	but	CC
cord-356188-rwf78stz	234	31	this	this	DT
cord-356188-rwf78stz	234	32	CTL	CTL	NNP
cord-356188-rwf78stz	234	33	response	response	NN
cord-356188-rwf78stz	234	34	wanes	wane	VBZ
cord-356188-rwf78stz	234	35	over	over	IN
cord-356188-rwf78stz	234	36	time	time	NN
cord-356188-rwf78stz	234	37	[	[	-LRB-
cord-356188-rwf78stz	234	38	184	184	CD
cord-356188-rwf78stz	234	39	]	]	-RRB-
cord-356188-rwf78stz	234	40	.	.	.
cord-356188-rwf78stz	235	1	Likewise	likewise	RB
cord-356188-rwf78stz	235	2	,	,	,
cord-356188-rwf78stz	235	3	vaccinated	vaccinated	JJ
cord-356188-rwf78stz	235	4	individuals	individual	NNS
cord-356188-rwf78stz	235	5	,	,	,
cord-356188-rwf78stz	235	6	who	who	WP
cord-356188-rwf78stz	235	7	were	be	VBD
cord-356188-rwf78stz	235	8	then	then	RB
cord-356188-rwf78stz	235	9	naturally	naturally	RB
cord-356188-rwf78stz	235	10	infected	infect	VBN
cord-356188-rwf78stz	235	11	with	with	IN
cord-356188-rwf78stz	235	12	A(H1N1)pdm09	A(H1N1)pdm09	NNP
cord-356188-rwf78stz	235	13	,	,	,
cord-356188-rwf78stz	235	14	had	have	VBD
cord-356188-rwf78stz	235	15	T	t	NN
cord-356188-rwf78stz	235	16	cell	cell	NN
cord-356188-rwf78stz	235	17	responses	response	NNS
cord-356188-rwf78stz	235	18	increase	increase	VBP
cord-356188-rwf78stz	235	19	by	by	IN
cord-356188-rwf78stz	235	20	twofold	twofold	RB
cord-356188-rwf78stz	235	21	early	early	RB
cord-356188-rwf78stz	235	22	after	after	IN
cord-356188-rwf78stz	235	23	infection	infection	NN
cord-356188-rwf78stz	235	24	[	[	-LRB-
cord-356188-rwf78stz	235	25	174	174	CD
cord-356188-rwf78stz	235	26	]	]	-RRB-
cord-356188-rwf78stz	235	27	.	.	.
cord-356188-rwf78stz	236	1	Memory	Memory	NNP
cord-356188-rwf78stz	236	2	CD4	CD4	NNP
cord-356188-rwf78stz	237	1	ϩ	ϩ	LS
cord-356188-rwf78stz	237	2	or	or	CC
cord-356188-rwf78stz	237	3	CD8	CD8	NNP
cord-356188-rwf78stz	237	4	ϩ	ϩ	WDT
cord-356188-rwf78stz	237	5	T	T	NNP
cord-356188-rwf78stz	237	6	cells	cell	NNS
cord-356188-rwf78stz	237	7	isolated	isolate	VBN
cord-356188-rwf78stz	237	8	from	from	IN
cord-356188-rwf78stz	237	9	PBMCs	pbmc	NNS
cord-356188-rwf78stz	237	10	of	of	IN
cord-356188-rwf78stz	237	11	healthy	healthy	JJ
cord-356188-rwf78stz	237	12	individuals	individual	NNS
cord-356188-rwf78stz	237	13	are	be	VBP
cord-356188-rwf78stz	237	14	also	also	RB
cord-356188-rwf78stz	237	15	cross	cross	JJ
cord-356188-rwf78stz	237	16	-	-	JJ
cord-356188-rwf78stz	237	17	reactive	reactive	JJ
cord-356188-rwf78stz	237	18	against	against	IN
cord-356188-rwf78stz	237	19	proteins	protein	NNS
cord-356188-rwf78stz	237	20	of	of	IN
cord-356188-rwf78stz	237	21	heterologous	heterologous	JJ
cord-356188-rwf78stz	237	22	viruses	virus	NNS
cord-356188-rwf78stz	237	23	,	,	,
cord-356188-rwf78stz	237	24	including	include	VBG
cord-356188-rwf78stz	237	25	those	those	DT
cord-356188-rwf78stz	237	26	from	from	IN
cord-356188-rwf78stz	237	27	A(H1N1)pdm09	A(H1N1)pdm09	NNP
cord-356188-rwf78stz	237	28	and	and	CC
cord-356188-rwf78stz	237	29	A	A	NNP
cord-356188-rwf78stz	237	30	/	/	SYM
cord-356188-rwf78stz	237	31	H5N1	H5N1	NNP
cord-356188-rwf78stz	237	32	[	[	-LRB-
cord-356188-rwf78stz	237	33	91	91	CD
cord-356188-rwf78stz	237	34	]	]	-RRB-
cord-356188-rwf78stz	237	35	[	[	-LRB-
cord-356188-rwf78stz	237	36	92	92	CD
cord-356188-rwf78stz	237	37	]	]	-RRB-
cord-356188-rwf78stz	237	38	[	[	-LRB-
cord-356188-rwf78stz	237	39	93	93	CD
cord-356188-rwf78stz	237	40	]	]	-RRB-
cord-356188-rwf78stz	237	41	[	[	-LRB-
cord-356188-rwf78stz	237	42	94	94	CD
cord-356188-rwf78stz	237	43	]	]	-RRB-
cord-356188-rwf78stz	237	44	,	,	,
cord-356188-rwf78stz	237	45	but	but	CC
cord-356188-rwf78stz	237	46	immunocompromised	immunocompromised	JJ
cord-356188-rwf78stz	237	47	patients	patient	NNS
cord-356188-rwf78stz	237	48	do	do	VBP
cord-356188-rwf78stz	237	49	not	not	RB
cord-356188-rwf78stz	237	50	have	have	VB
cord-356188-rwf78stz	237	51	lasting	last	VBG
cord-356188-rwf78stz	237	52	antibody	antibody	NN
cord-356188-rwf78stz	237	53	or	or	CC
cord-356188-rwf78stz	237	54	CD4	CD4	NNP
cord-356188-rwf78stz	238	1	ϩ	ϩ	LS
cord-356188-rwf78stz	238	2	/CD8	/CD8	:
cord-356188-rwf78stz	238	3	ϩ	ϩ	LS
cord-356188-rwf78stz	238	4	memory	memory	NN
cord-356188-rwf78stz	238	5	responses	response	NNS
cord-356188-rwf78stz	238	6	following	follow	VBG
cord-356188-rwf78stz	238	7	natural	natural	JJ
cord-356188-rwf78stz	238	8	A(H1N1)pdm09	A(H1N1)pdm09	NNP
cord-356188-rwf78stz	238	9	infection	infection	NN
cord-356188-rwf78stz	238	10	[	[	-LRB-
cord-356188-rwf78stz	238	11	185	185	CD
cord-356188-rwf78stz	238	12	]	]	-RRB-
cord-356188-rwf78stz	238	13	.	.	.
cord-356188-rwf78stz	239	1	Furthermore	furthermore	RB
cord-356188-rwf78stz	239	2	,	,	,
cord-356188-rwf78stz	239	3	CTLs	ctl	NNS
cord-356188-rwf78stz	239	4	,	,	,
cord-356188-rwf78stz	239	5	isolated	isolate	VBN
cord-356188-rwf78stz	239	6	from	from	IN
cord-356188-rwf78stz	239	7	A(H1N1)pdm09-or	a(h1n1)pdm09-or	NN
cord-356188-rwf78stz	240	1	A	a	DT
cord-356188-rwf78stz	240	2	/	/	SYM
cord-356188-rwf78stz	240	3	H5N1-inexperienced	h5n1-inexperience	VBN
cord-356188-rwf78stz	240	4	individuals	individual	NNS
cord-356188-rwf78stz	240	5	with	with	IN
cord-356188-rwf78stz	240	6	a	a	DT
cord-356188-rwf78stz	240	7	memory	memory	NN
cord-356188-rwf78stz	241	1	CD45RA	cd45ra	NN
cord-356188-rwf78stz	241	2	med	med	JJ
cord-356188-rwf78stz	241	3	CD62	cd62	JJ
cord-356188-rwf78stz	241	4	ligand	ligand	NN
cord-356188-rwf78stz	242	1	lo	lo	NNP
cord-356188-rwf78stz	242	2	CCR7	CCR7	NNP
cord-356188-rwf78stz	242	3	Ϫ	Ϫ	NNP
cord-356188-rwf78stz	242	4	phenotype	phenotype	NN
cord-356188-rwf78stz	242	5	,	,	,
cord-356188-rwf78stz	242	6	will	will	MD
cord-356188-rwf78stz	242	7	respond	respond	VB
cord-356188-rwf78stz	242	8	robustly	robustly	RB
cord-356188-rwf78stz	242	9	to	to	IN
cord-356188-rwf78stz	242	10	peptide	peptide	JJ
cord-356188-rwf78stz	242	11	pools	pool	NNS
cord-356188-rwf78stz	242	12	and	and	CC
cord-356188-rwf78stz	242	13	influenza	influenza	NN
cord-356188-rwf78stz	242	14	-	-	HYPH
cord-356188-rwf78stz	242	15	infected	infect	VBN
cord-356188-rwf78stz	242	16	cells	cell	NNS
cord-356188-rwf78stz	242	17	[	[	-LRB-
cord-356188-rwf78stz	242	18	34	34	CD
cord-356188-rwf78stz	242	19	,	,	,
cord-356188-rwf78stz	242	20	177	177	CD
cord-356188-rwf78stz	242	21	,	,	,
cord-356188-rwf78stz	242	22	186	186	CD
cord-356188-rwf78stz	242	23	,	,	,
cord-356188-rwf78stz	242	24	187	187	CD
cord-356188-rwf78stz	242	25	]	]	-RRB-
cord-356188-rwf78stz	242	26	,	,	,
cord-356188-rwf78stz	242	27	suggesting	suggest	VBG
cord-356188-rwf78stz	242	28	that	that	IN
cord-356188-rwf78stz	242	29	T	T	NNP
cord-356188-rwf78stz	242	30	cells	cell	NNS
cord-356188-rwf78stz	242	31	may	may	MD
cord-356188-rwf78stz	242	32	provide	provide	VB
cord-356188-rwf78stz	242	33	some	some	DT
cord-356188-rwf78stz	242	34	level	level	NN
cord-356188-rwf78stz	242	35	of	of	IN
cord-356188-rwf78stz	242	36	protection	protection	NN
cord-356188-rwf78stz	242	37	against	against	IN
cord-356188-rwf78stz	242	38	conserved	conserved	JJ
cord-356188-rwf78stz	242	39	epitopes	epitope	NNS
cord-356188-rwf78stz	242	40	[	[	-LRB-
cord-356188-rwf78stz	242	41	110	110	CD
cord-356188-rwf78stz	242	42	]	]	-RRB-
cord-356188-rwf78stz	242	43	.	.	.
cord-356188-rwf78stz	243	1	Although	although	IN
cord-356188-rwf78stz	243	2	nonconserved	nonconserved	JJ
cord-356188-rwf78stz	243	3	regions	region	NNS
cord-356188-rwf78stz	243	4	of	of	IN
cord-356188-rwf78stz	243	5	the	the	DT
cord-356188-rwf78stz	243	6	virus	virus	NN
cord-356188-rwf78stz	243	7	may	may	MD
cord-356188-rwf78stz	243	8	effectively	effectively	RB
cord-356188-rwf78stz	243	9	escape	escape	VB
cord-356188-rwf78stz	243	10	recognition	recognition	NN
cord-356188-rwf78stz	243	11	by	by	IN
cord-356188-rwf78stz	243	12	T	t	NN
cord-356188-rwf78stz	243	13	cells	cell	NNS
cord-356188-rwf78stz	243	14	[	[	-LRB-
cord-356188-rwf78stz	243	15	188	188	CD
cord-356188-rwf78stz	243	16	]	]	-RRB-
cord-356188-rwf78stz	243	17	,	,	,
cord-356188-rwf78stz	243	18	the	the	DT
cord-356188-rwf78stz	243	19	majority	majority	NN
cord-356188-rwf78stz	243	20	of	of	IN
cord-356188-rwf78stz	243	21	T	T	NNP
cord-356188-rwf78stz	243	22	cell	cell	NN
cord-356188-rwf78stz	243	23	responses	response	NNS
cord-356188-rwf78stz	243	24	is	be	VBZ
cord-356188-rwf78stz	243	25	elicited	elicit	VBN
cord-356188-rwf78stz	243	26	against	against	IN
cord-356188-rwf78stz	243	27	conserved	conserve	VBN
cord-356188-rwf78stz	243	28	,	,	,
cord-356188-rwf78stz	243	29	internal	internal	JJ
cord-356188-rwf78stz	243	30	viral	viral	JJ
cord-356188-rwf78stz	243	31	proteins	protein	NNS
cord-356188-rwf78stz	243	32	,	,	,
cord-356188-rwf78stz	243	33	generating	generate	VBG
cord-356188-rwf78stz	243	34	much	much	JJ
cord-356188-rwf78stz	243	35	interest	interest	NN
cord-356188-rwf78stz	243	36	in	in	IN
cord-356188-rwf78stz	243	37	vaccine	vaccine	NN
cord-356188-rwf78stz	243	38	or	or	CC
cord-356188-rwf78stz	243	39	therapeutic	therapeutic	JJ
cord-356188-rwf78stz	243	40	strategies	strategy	NNS
cord-356188-rwf78stz	243	41	that	that	WDT
cord-356188-rwf78stz	243	42	involve	involve	VBP
cord-356188-rwf78stz	243	43	T	T	NNP
cord-356188-rwf78stz	243	44	cell	cell	NN
cord-356188-rwf78stz	243	45	-	-	HYPH
cord-356188-rwf78stz	243	46	mediated	mediate	VBN
cord-356188-rwf78stz	243	47	immunity	immunity	NN
cord-356188-rwf78stz	243	48	.	.	.
cord-356188-rwf78stz	244	1	A	a	DT
cord-356188-rwf78stz	244	2	frequently	frequently	RB
cord-356188-rwf78stz	244	3	neglected	neglect	VBN
cord-356188-rwf78stz	244	4	population	population	NN
cord-356188-rwf78stz	244	5	of	of	IN
cord-356188-rwf78stz	244	6	lymphocytes	lymphocyte	NNS
cord-356188-rwf78stz	244	7	,	,	,
cord-356188-rwf78stz	244	8	␥	␥	NNP
cord-356188-rwf78stz	244	9	␦	␦	NN
cord-356188-rwf78stz	244	10	T	t	NN
cord-356188-rwf78stz	244	11	cells	cell	NNS
cord-356188-rwf78stz	244	12	comprise	comprise	VBP
cord-356188-rwf78stz	244	13	1	1	CD
cord-356188-rwf78stz	244	14	-	-	SYM
cord-356188-rwf78stz	244	15	5	5	CD
cord-356188-rwf78stz	244	16	%	%	NN
cord-356188-rwf78stz	244	17	of	of	IN
cord-356188-rwf78stz	244	18	T	t	NN
cord-356188-rwf78stz	244	19	cells	cell	NNS
cord-356188-rwf78stz	244	20	in	in	IN
cord-356188-rwf78stz	244	21	the	the	DT
cord-356188-rwf78stz	244	22	blood	blood	NN
cord-356188-rwf78stz	244	23	of	of	IN
cord-356188-rwf78stz	244	24	humans	human	NNS
cord-356188-rwf78stz	244	25	,	,	,
cord-356188-rwf78stz	244	26	the	the	DT
cord-356188-rwf78stz	244	27	majority	majority	NN
cord-356188-rwf78stz	244	28	of	of	IN
cord-356188-rwf78stz	244	29	which	which	WDT
cord-356188-rwf78stz	244	30	are	be	VBP
cord-356188-rwf78stz	244	31	V	v	NN
cord-356188-rwf78stz	244	32	␥	␥	CD
cord-356188-rwf78stz	244	33	9V	9v	JJ
cord-356188-rwf78stz	244	34	␦	␦	NN
cord-356188-rwf78stz	244	35	2	2	CD
cord-356188-rwf78stz	244	36	T	t	NN
cord-356188-rwf78stz	244	37	cells	cell	NNS
cord-356188-rwf78stz	244	38	.	.	.
cord-356188-rwf78stz	245	1	These	these	DT
cord-356188-rwf78stz	245	2	␥	␥	NNP
cord-356188-rwf78stz	245	3	␦	␦	NN
cord-356188-rwf78stz	245	4	T	t	NN
cord-356188-rwf78stz	245	5	cells	cell	NNS
cord-356188-rwf78stz	245	6	are	be	VBP
cord-356188-rwf78stz	245	7	considered	consider	VBN
cord-356188-rwf78stz	245	8	to	to	TO
cord-356188-rwf78stz	245	9	be	be	VB
cord-356188-rwf78stz	245	10	a	a	DT
cord-356188-rwf78stz	245	11	major	major	JJ
cord-356188-rwf78stz	245	12	innate	innate	NN
cord-356188-rwf78stz	245	13	-	-	HYPH
cord-356188-rwf78stz	245	14	like	like	JJ
cord-356188-rwf78stz	245	15	T	t	NN
cord-356188-rwf78stz	245	16	cell	cell	NN
cord-356188-rwf78stz	245	17	subset	subset	NN
cord-356188-rwf78stz	245	18	(	(	-LRB-
cord-356188-rwf78stz	245	19	reviewed	review	VBN
cord-356188-rwf78stz	245	20	in	in	IN
cord-356188-rwf78stz	245	21	ref	ref	NN
cord-356188-rwf78stz	245	22	.	.	.
cord-356188-rwf78stz	246	1	[	[	-LRB-
cord-356188-rwf78stz	246	2	189	189	CD
cord-356188-rwf78stz	246	3	]	]	-RRB-
cord-356188-rwf78stz	246	4	)	)	-RRB-
cord-356188-rwf78stz	246	5	,	,	,
cord-356188-rwf78stz	246	6	and	and	CC
cord-356188-rwf78stz	247	1	in	in	FW
cord-356188-rwf78stz	247	2	vitro	vitro	FW
cord-356188-rwf78stz	247	3	studies	study	NNS
cord-356188-rwf78stz	247	4	suggest	suggest	VBP
cord-356188-rwf78stz	247	5	that	that	IN
cord-356188-rwf78stz	247	6	activated	activate	VBN
cord-356188-rwf78stz	247	7	human	human	NN
cord-356188-rwf78stz	247	8	V	v	NN
cord-356188-rwf78stz	247	9	␥	␥	NNP
cord-356188-rwf78stz	247	10	9V	9v	JJ
cord-356188-rwf78stz	247	11	␦	␦	NN
cord-356188-rwf78stz	247	12	2	2	CD
cord-356188-rwf78stz	247	13	T	t	NN
cord-356188-rwf78stz	247	14	cells	cell	NNS
cord-356188-rwf78stz	247	15	may	may	MD
cord-356188-rwf78stz	247	16	have	have	VB
cord-356188-rwf78stz	247	17	a	a	DT
cord-356188-rwf78stz	247	18	role	role	NN
cord-356188-rwf78stz	247	19	in	in	IN
cord-356188-rwf78stz	247	20	the	the	DT
cord-356188-rwf78stz	247	21	antiviral	antiviral	JJ
cord-356188-rwf78stz	247	22	response	response	NN
cord-356188-rwf78stz	247	23	by	by	IN
cord-356188-rwf78stz	247	24	killing	kill	VBG
cord-356188-rwf78stz	247	25	influenza	influenza	NN
cord-356188-rwf78stz	247	26	-	-	HYPH
cord-356188-rwf78stz	247	27	infected	infect	VBN
cord-356188-rwf78stz	247	28	,	,	,
cord-356188-rwf78stz	247	29	monocyte	monocyte	NN
cord-356188-rwf78stz	247	30	-	-	HYPH
cord-356188-rwf78stz	247	31	derived	derive	VBN
cord-356188-rwf78stz	247	32	macrophages	macrophage	NNS
cord-356188-rwf78stz	247	33	and	and	CC
cord-356188-rwf78stz	247	34	producing	produce	VBG
cord-356188-rwf78stz	247	35	high	high	JJ
cord-356188-rwf78stz	247	36	levels	level	NNS
cord-356188-rwf78stz	247	37	of	of	IN
cord-356188-rwf78stz	247	38	IFN-	IFN-	NNP
cord-356188-rwf78stz	247	39	␥	␥	ADD
cord-356188-rwf78stz	247	40	[	[	-LRB-
cord-356188-rwf78stz	247	41	190	190	CD
cord-356188-rwf78stz	247	42	,	,	,
cord-356188-rwf78stz	247	43	191	191	CD
cord-356188-rwf78stz	247	44	]	]	-RRB-
cord-356188-rwf78stz	247	45	.	.	.
cord-356188-rwf78stz	248	1	In	in	IN
cord-356188-rwf78stz	248	2	particular	particular	JJ
cord-356188-rwf78stz	248	3	,	,	,
cord-356188-rwf78stz	248	4	neonates	neonate	NNS
cord-356188-rwf78stz	248	5	are	be	VBP
cord-356188-rwf78stz	248	6	known	know	VBN
cord-356188-rwf78stz	248	7	to	to	TO
cord-356188-rwf78stz	248	8	have	have	VB
cord-356188-rwf78stz	248	9	compromised	compromise	VBN
cord-356188-rwf78stz	248	10	cellular	cellular	JJ
cord-356188-rwf78stz	248	11	immune	immune	JJ
cord-356188-rwf78stz	248	12	responses	response	NNS
cord-356188-rwf78stz	248	13	and	and	CC
cord-356188-rwf78stz	248	14	represent	represent	VBP
cord-356188-rwf78stz	248	15	an	an	DT
cord-356188-rwf78stz	248	16	important	important	JJ
cord-356188-rwf78stz	248	17	target	target	NN
cord-356188-rwf78stz	248	18	population	population	NN
cord-356188-rwf78stz	248	19	for	for	IN
cord-356188-rwf78stz	248	20	influenza	influenza	NN
cord-356188-rwf78stz	248	21	immunization	immunization	NN
cord-356188-rwf78stz	248	22	.	.	.
cord-356188-rwf78stz	249	1	Despite	despite	IN
cord-356188-rwf78stz	249	2	being	be	VBG
cord-356188-rwf78stz	249	3	such	such	PDT
cord-356188-rwf78stz	249	4	a	a	DT
cord-356188-rwf78stz	249	5	critical	critical	JJ
cord-356188-rwf78stz	249	6	target	target	NN
cord-356188-rwf78stz	249	7	population	population	NN
cord-356188-rwf78stz	249	8	,	,	,
cord-356188-rwf78stz	249	9	there	there	EX
cord-356188-rwf78stz	249	10	are	be	VBP
cord-356188-rwf78stz	249	11	relatively	relatively	RB
cord-356188-rwf78stz	249	12	few	few	JJ
cord-356188-rwf78stz	249	13	neonatal	neonatal	JJ
cord-356188-rwf78stz	249	14	models	model	NNS
cord-356188-rwf78stz	249	15	of	of	IN
cord-356188-rwf78stz	249	16	respiratory	respiratory	JJ
cord-356188-rwf78stz	249	17	infections	infection	NNS
cord-356188-rwf78stz	249	18	,	,	,
cord-356188-rwf78stz	249	19	and	and	CC
cord-356188-rwf78stz	249	20	for	for	IN
cord-356188-rwf78stz	249	21	ethical	ethical	JJ
cord-356188-rwf78stz	249	22	reasons	reason	NNS
cord-356188-rwf78stz	249	23	,	,	,
cord-356188-rwf78stz	249	24	it	-PRON-	PRP
cord-356188-rwf78stz	249	25	is	be	VBZ
cord-356188-rwf78stz	249	26	appropriately	appropriately	RB
cord-356188-rwf78stz	249	27	difficult	difficult	JJ
cord-356188-rwf78stz	249	28	to	to	TO
cord-356188-rwf78stz	249	29	acquire	acquire	VB
cord-356188-rwf78stz	249	30	data	datum	NNS
cord-356188-rwf78stz	249	31	from	from	IN
cord-356188-rwf78stz	249	32	human	human	JJ
cord-356188-rwf78stz	249	33	neonates	neonate	NNS
cord-356188-rwf78stz	249	34	.	.	.
cord-356188-rwf78stz	250	1	In	in	IN
cord-356188-rwf78stz	250	2	the	the	DT
cord-356188-rwf78stz	250	3	case	case	NN
cord-356188-rwf78stz	250	4	of	of	IN
cord-356188-rwf78stz	250	5	RSV	RSV	NNP
cord-356188-rwf78stz	250	6	infection	infection	NN
cord-356188-rwf78stz	250	7	,	,	,
cord-356188-rwf78stz	250	8	murine	murine	JJ
cord-356188-rwf78stz	250	9	neonate	neonate	NN
cord-356188-rwf78stz	250	10	models	model	NNS
cord-356188-rwf78stz	250	11	suggest	suggest	VBP
cord-356188-rwf78stz	250	12	that	that	IN
cord-356188-rwf78stz	250	13	the	the	DT
cord-356188-rwf78stz	250	14	age	age	NN
cord-356188-rwf78stz	250	15	of	of	IN
cord-356188-rwf78stz	250	16	primary	primary	JJ
cord-356188-rwf78stz	250	17	viral	viral	JJ
cord-356188-rwf78stz	250	18	infection	infection	NN
cord-356188-rwf78stz	250	19	can	can	MD
cord-356188-rwf78stz	250	20	determine	determine	VB
cord-356188-rwf78stz	250	21	the	the	DT
cord-356188-rwf78stz	250	22	immunopathology	immunopathology	NN
cord-356188-rwf78stz	250	23	of	of	IN
cord-356188-rwf78stz	250	24	a	a	DT
cord-356188-rwf78stz	250	25	secondary	secondary	JJ
cord-356188-rwf78stz	250	26	viral	viral	JJ
cord-356188-rwf78stz	250	27	infection	infection	NN
cord-356188-rwf78stz	250	28	[	[	-LRB-
cord-356188-rwf78stz	250	29	192	192	CD
cord-356188-rwf78stz	250	30	]	]	-RRB-
cord-356188-rwf78stz	250	31	[	[	-LRB-
cord-356188-rwf78stz	250	32	193	193	CD
cord-356188-rwf78stz	250	33	]	]	-RRB-
cord-356188-rwf78stz	250	34	[	[	-LRB-
cord-356188-rwf78stz	250	35	194	194	CD
cord-356188-rwf78stz	250	36	]	]	-RRB-
cord-356188-rwf78stz	250	37	.	.	.
cord-356188-rwf78stz	251	1	During	during	IN
cord-356188-rwf78stz	251	2	RSV	RSV	NNP
cord-356188-rwf78stz	251	3	infection	infection	NN
cord-356188-rwf78stz	251	4	,	,	,
cord-356188-rwf78stz	251	5	younger	young	JJR
cord-356188-rwf78stz	251	6	murine	murine	JJ
cord-356188-rwf78stz	251	7	neonates	neonate	NNS
cord-356188-rwf78stz	251	8	(	(	-LRB-
cord-356188-rwf78stz	251	9	Յ7	յ7	JJ
cord-356188-rwf78stz	251	10	days	day	NNS
cord-356188-rwf78stz	251	11	)	)	-RRB-
cord-356188-rwf78stz	251	12	will	will	MD
cord-356188-rwf78stz	251	13	develop	develop	VB
cord-356188-rwf78stz	251	14	an	an	DT
cord-356188-rwf78stz	251	15	immune	immune	JJ
cord-356188-rwf78stz	251	16	response	response	NN
cord-356188-rwf78stz	251	17	characterized	characterize	VBN
cord-356188-rwf78stz	251	18	by	by	IN
cord-356188-rwf78stz	251	19	increased	increase	VBN
cord-356188-rwf78stz	251	20	eosinophil	eosinophil	NN
cord-356188-rwf78stz	251	21	and	and	CC
cord-356188-rwf78stz	251	22	T	T	NNP
cord-356188-rwf78stz	251	23	cell	cell	NN
cord-356188-rwf78stz	251	24	recruitment	recruitment	NN
cord-356188-rwf78stz	251	25	to	to	IN
cord-356188-rwf78stz	251	26	the	the	DT
cord-356188-rwf78stz	251	27	lungs	lung	NNS
cord-356188-rwf78stz	251	28	,	,	,
cord-356188-rwf78stz	251	29	enhanced	enhance	VBN
cord-356188-rwf78stz	251	30	airway	airway	NN
cord-356188-rwf78stz	251	31	hyper	hyper	NN
cord-356188-rwf78stz	251	32	-	-	NN
cord-356188-rwf78stz	251	33	responsiveness	responsiveness	NN
cord-356188-rwf78stz	251	34	,	,	,
cord-356188-rwf78stz	251	35	and	and	CC
cord-356188-rwf78stz	251	36	higher	high	JJR
cord-356188-rwf78stz	251	37	IL-13	IL-13	NNP
cord-356188-rwf78stz	251	38	levels	level	NNS
cord-356188-rwf78stz	251	39	upon	upon	IN
cord-356188-rwf78stz	251	40	reinfection	reinfection	NN
cord-356188-rwf78stz	251	41	12	12	CD
cord-356188-rwf78stz	251	42	weeks	week	NNS
cord-356188-rwf78stz	251	43	later	later	RB
cord-356188-rwf78stz	251	44	,	,	,
cord-356188-rwf78stz	251	45	whereas	whereas	IN
cord-356188-rwf78stz	251	46	older	old	JJR
cord-356188-rwf78stz	251	47	mice	mouse	NNS
cord-356188-rwf78stz	251	48	(	(	-LRB-
cord-356188-rwf78stz	251	49	Ն4	ն4	NN
cord-356188-rwf78stz	251	50	weeks	week	NNS
cord-356188-rwf78stz	251	51	)	)	-RRB-
cord-356188-rwf78stz	251	52	develop	develop	VB
cord-356188-rwf78stz	251	53	an	an	DT
cord-356188-rwf78stz	251	54	immune	immune	JJ
cord-356188-rwf78stz	251	55	response	response	NN
cord-356188-rwf78stz	251	56	characterized	characterize	VBN
cord-356188-rwf78stz	251	57	by	by	IN
cord-356188-rwf78stz	251	58	decreased	decrease	VBN
cord-356188-rwf78stz	251	59	T	T	NNP
cord-356188-rwf78stz	251	60	cell	cell	NN
cord-356188-rwf78stz	251	61	and	and	CC
cord-356188-rwf78stz	251	62	eosinophil	eosinophil	NN
cord-356188-rwf78stz	251	63	recruitment	recruitment	NN
cord-356188-rwf78stz	251	64	to	to	IN
cord-356188-rwf78stz	251	65	the	the	DT
cord-356188-rwf78stz	251	66	lungs	lung	NNS
cord-356188-rwf78stz	251	67	upon	upon	IN
cord-356188-rwf78stz	251	68	reinfection	reinfection	NN
cord-356188-rwf78stz	251	69	[	[	-LRB-
cord-356188-rwf78stz	251	70	192	192	CD
cord-356188-rwf78stz	251	71	,	,	,
cord-356188-rwf78stz	251	72	193	193	CD
cord-356188-rwf78stz	251	73	]	]	-RRB-
cord-356188-rwf78stz	251	74	.	.	.
cord-356188-rwf78stz	252	1	Likewise	likewise	RB
cord-356188-rwf78stz	252	2	,	,	,
cord-356188-rwf78stz	252	3	a	a	DT
cord-356188-rwf78stz	252	4	neonatal	neonatal	JJ
cord-356188-rwf78stz	252	5	mouse	mouse	NN
cord-356188-rwf78stz	252	6	model	model	NN
cord-356188-rwf78stz	252	7	of	of	IN
cord-356188-rwf78stz	252	8	influenza	influenza	NN
cord-356188-rwf78stz	252	9	A	a	DT
cord-356188-rwf78stz	252	10	virus	virus	NN
cord-356188-rwf78stz	252	11	showed	show	VBD
cord-356188-rwf78stz	252	12	that	that	IN
cord-356188-rwf78stz	252	13	early	early	JJ
cord-356188-rwf78stz	252	14	infection	infection	NN
cord-356188-rwf78stz	252	15	was	be	VBD
cord-356188-rwf78stz	252	16	associated	associate	VBN
cord-356188-rwf78stz	252	17	with	with	IN
cord-356188-rwf78stz	252	18	decreased	decreased	JJ
cord-356188-rwf78stz	252	19	CD8	CD8	NNP
cord-356188-rwf78stz	252	20	ϩ	ϩ	NNP
cord-356188-rwf78stz	252	21	T	T	NNP
cord-356188-rwf78stz	252	22	cell	cell	NN
cord-356188-rwf78stz	252	23	recruitment	recruitment	NN
cord-356188-rwf78stz	252	24	and	and	CC
cord-356188-rwf78stz	252	25	function	function	NN
cord-356188-rwf78stz	252	26	and	and	CC
cord-356188-rwf78stz	252	27	enhanced	enhance	VBN
cord-356188-rwf78stz	252	28	airway	airway	NN
cord-356188-rwf78stz	252	29	inflammation	inflammation	NN
cord-356188-rwf78stz	252	30	[	[	-LRB-
cord-356188-rwf78stz	252	31	195	195	CD
cord-356188-rwf78stz	252	32	]	]	-RRB-
cord-356188-rwf78stz	252	33	.	.	.
cord-356188-rwf78stz	253	1	These	these	DT
cord-356188-rwf78stz	253	2	studies	study	NNS
cord-356188-rwf78stz	253	3	highlight	highlight	VBP
cord-356188-rwf78stz	253	4	an	an	DT
cord-356188-rwf78stz	253	5	important	important	JJ
cord-356188-rwf78stz	253	6	concept	concept	NN
cord-356188-rwf78stz	253	7	,	,	,
cord-356188-rwf78stz	253	8	whereby	whereby	WRB
cord-356188-rwf78stz	253	9	infection	infection	NN
cord-356188-rwf78stz	253	10	too	too	RB
cord-356188-rwf78stz	253	11	early	early	JJ
cord-356188-rwf78stz	253	12	results	result	NNS
cord-356188-rwf78stz	253	13	not	not	RB
cord-356188-rwf78stz	253	14	in	in	IN
cord-356188-rwf78stz	253	15	protective	protective	JJ
cord-356188-rwf78stz	253	16	immunity	immunity	NN
cord-356188-rwf78stz	253	17	but	but	CC
cord-356188-rwf78stz	253	18	immunopathogenesis	immunopathogenesis	NN
cord-356188-rwf78stz	253	19	.	.	.
cord-356188-rwf78stz	254	1	Consistent	consistent	JJ
cord-356188-rwf78stz	254	2	with	with	IN
cord-356188-rwf78stz	254	3	an	an	DT
cord-356188-rwf78stz	254	4	age	age	NN
cord-356188-rwf78stz	254	5	-	-	HYPH
cord-356188-rwf78stz	254	6	dependent	dependent	JJ
cord-356188-rwf78stz	254	7	defect	defect	NN
cord-356188-rwf78stz	254	8	in	in	IN
cord-356188-rwf78stz	254	9	adaptive	adaptive	JJ
cord-356188-rwf78stz	254	10	immunity	immunity	NN
cord-356188-rwf78stz	254	11	,	,	,
cord-356188-rwf78stz	254	12	during	during	IN
cord-356188-rwf78stz	254	13	RSV	RSV	NNP
cord-356188-rwf78stz	254	14	and	and	CC
cord-356188-rwf78stz	254	15	influenza	influenza	NN
cord-356188-rwf78stz	254	16	infection	infection	NN
cord-356188-rwf78stz	254	17	of	of	IN
cord-356188-rwf78stz	254	18	infants	infant	NNS
cord-356188-rwf78stz	254	19	,	,	,
cord-356188-rwf78stz	254	20	few	few	JJ
cord-356188-rwf78stz	254	21	CD4	CD4	NNP
cord-356188-rwf78stz	254	22	ϩ	ϩ	NNP
cord-356188-rwf78stz	254	23	or	or	CC
cord-356188-rwf78stz	254	24	CD8	CD8	NNP
cord-356188-rwf78stz	254	25	ϩ	ϩ	WDT
cord-356188-rwf78stz	254	26	T	T	NNP
cord-356188-rwf78stz	254	27	cells	cell	NNS
cord-356188-rwf78stz	254	28	or	or	CC
cord-356188-rwf78stz	254	29	CD56	CD56	NNP
cord-356188-rwf78stz	254	30	ϩ	ϩ	NN
cord-356188-rwf78stz	254	31	NK	NK	NNP
cord-356188-rwf78stz	254	32	cells	cell	NNS
cord-356188-rwf78stz	254	33	are	be	VBP
cord-356188-rwf78stz	254	34	found	find	VBN
cord-356188-rwf78stz	254	35	in	in	IN
cord-356188-rwf78stz	254	36	the	the	DT
cord-356188-rwf78stz	254	37	upper	upper	JJ
cord-356188-rwf78stz	254	38	and	and	CC
cord-356188-rwf78stz	254	39	lower	low	JJR
cord-356188-rwf78stz	254	40	airways	airway	NNS
cord-356188-rwf78stz	254	41	[	[	-LRB-
cord-356188-rwf78stz	254	42	100	100	CD
cord-356188-rwf78stz	254	43	,	,	,
cord-356188-rwf78stz	254	44	103	103	CD
cord-356188-rwf78stz	254	45	,	,	,
cord-356188-rwf78stz	254	46	104	104	CD
cord-356188-rwf78stz	254	47	]	]	-RRB-
cord-356188-rwf78stz	254	48	,	,	,
cord-356188-rwf78stz	254	49	in	in	IN
cord-356188-rwf78stz	254	50	contrast	contrast	NN
cord-356188-rwf78stz	254	51	to	to	IN
cord-356188-rwf78stz	254	52	the	the	DT
cord-356188-rwf78stz	254	53	observed	observed	JJ
cord-356188-rwf78stz	254	54	infiltration	infiltration	NN
cord-356188-rwf78stz	254	55	of	of	IN
cord-356188-rwf78stz	254	56	lymphocytes	lymphocyte	NNS
cord-356188-rwf78stz	254	57	in	in	IN
cord-356188-rwf78stz	254	58	adult	adult	NN
cord-356188-rwf78stz	254	59	A	A	NNP
cord-356188-rwf78stz	254	60	/	/	SYM
cord-356188-rwf78stz	254	61	H5N1	H5N1	NNP
cord-356188-rwf78stz	254	62	influenza	influenza	NN
cord-356188-rwf78stz	254	63	[	[	-LRB-
cord-356188-rwf78stz	254	64	106	106	CD
cord-356188-rwf78stz	254	65	]	]	-RRB-
cord-356188-rwf78stz	254	66	and	and	CC
cord-356188-rwf78stz	254	67	SARS	SARS	NNP
cord-356188-rwf78stz	254	68	CoV	CoV	NNP
cord-356188-rwf78stz	254	69	infections	infection	NNS
cord-356188-rwf78stz	254	70	[	[	-LRB-
cord-356188-rwf78stz	254	71	196	196	CD
cord-356188-rwf78stz	254	72	,	,	,
cord-356188-rwf78stz	254	73	197	197	CD
cord-356188-rwf78stz	254	74	]	]	-RRB-
cord-356188-rwf78stz	254	75	.	.	.
cord-356188-rwf78stz	255	1	Moreover	moreover	RB
cord-356188-rwf78stz	255	2	,	,	,
cord-356188-rwf78stz	255	3	fatal	fatal	JJ
cord-356188-rwf78stz	255	4	cases	case	NNS
cord-356188-rwf78stz	255	5	of	of	IN
cord-356188-rwf78stz	255	6	A(H1N1)pdm09	A(H1N1)pdm09	NNP
cord-356188-rwf78stz	255	7	had	have	VBD
cord-356188-rwf78stz	255	8	increased	increase	VBN
cord-356188-rwf78stz	255	9	numbers	number	NNS
cord-356188-rwf78stz	255	10	of	of	IN
cord-356188-rwf78stz	255	11	CD8	CD8	NNP
cord-356188-rwf78stz	255	12	ϩ	ϩ	WDT
cord-356188-rwf78stz	255	13	T	T	NNP
cord-356188-rwf78stz	255	14	cells	cell	NNS
cord-356188-rwf78stz	255	15	and	and	CC
cord-356188-rwf78stz	255	16	granzyme	granzyme	NNS
cord-356188-rwf78stz	255	17	B	B	NNP
cord-356188-rwf78stz	255	18	ϩ	ϩ	NN
cord-356188-rwf78stz	255	19	cells	cell	NNS
cord-356188-rwf78stz	255	20	in	in	IN
cord-356188-rwf78stz	255	21	their	-PRON-	PRP$
cord-356188-rwf78stz	255	22	lungs	lung	NNS
cord-356188-rwf78stz	255	23	[	[	-LRB-
cord-356188-rwf78stz	255	24	33	33	CD
cord-356188-rwf78stz	255	25	]	]	-RRB-
cord-356188-rwf78stz	255	26	.	.	.
cord-356188-rwf78stz	256	1	This	this	DT
cord-356188-rwf78stz	256	2	observation	observation	NN
cord-356188-rwf78stz	256	3	may	may	MD
cord-356188-rwf78stz	256	4	represent	represent	VB
cord-356188-rwf78stz	256	5	a	a	DT
cord-356188-rwf78stz	256	6	correlation	correlation	NN
cord-356188-rwf78stz	256	7	with	with	IN
cord-356188-rwf78stz	256	8	higher	high	JJR
cord-356188-rwf78stz	256	9	levels	level	NNS
cord-356188-rwf78stz	256	10	of	of	IN
cord-356188-rwf78stz	256	11	viral	viral	JJ
cord-356188-rwf78stz	256	12	antigen	antigen	NN
cord-356188-rwf78stz	256	13	or	or	CC
cord-356188-rwf78stz	256	14	may	may	MD
cord-356188-rwf78stz	256	15	indicate	indicate	VB
cord-356188-rwf78stz	256	16	a	a	DT
cord-356188-rwf78stz	256	17	pathogenic	pathogenic	JJ
cord-356188-rwf78stz	256	18	role	role	NN
cord-356188-rwf78stz	256	19	of	of	IN
cord-356188-rwf78stz	256	20	exuberant	exuberant	JJ
cord-356188-rwf78stz	256	21	CD8	CD8	NNP
cord-356188-rwf78stz	256	22	ϩ	ϩ	NNP
cord-356188-rwf78stz	256	23	T	T	NNP
cord-356188-rwf78stz	256	24	cell	cell	NN
cord-356188-rwf78stz	256	25	responses	response	NNS
cord-356188-rwf78stz	256	26	.	.	.
cord-356188-rwf78stz	257	1	On	on	IN
cord-356188-rwf78stz	257	2	the	the	DT
cord-356188-rwf78stz	257	3	other	other	JJ
cord-356188-rwf78stz	257	4	hand	hand	NN
cord-356188-rwf78stz	257	5	,	,	,
cord-356188-rwf78stz	257	6	the	the	DT
cord-356188-rwf78stz	257	7	elderly	elderly	JJ
cord-356188-rwf78stz	257	8	have	have	VBP
cord-356188-rwf78stz	257	9	been	be	VBN
cord-356188-rwf78stz	257	10	shown	show	VBN
cord-356188-rwf78stz	257	11	to	to	TO
cord-356188-rwf78stz	257	12	have	have	VB
cord-356188-rwf78stz	257	13	reduced	reduce	VBN
cord-356188-rwf78stz	257	14	CTL	ctl	NN
cord-356188-rwf78stz	257	15	activity	activity	NN
cord-356188-rwf78stz	257	16	compared	compare	VBN
cord-356188-rwf78stz	257	17	with	with	IN
cord-356188-rwf78stz	257	18	younger	young	JJR
cord-356188-rwf78stz	257	19	individuals	individual	NNS
cord-356188-rwf78stz	257	20	,	,	,
cord-356188-rwf78stz	257	21	and	and	CC
cord-356188-rwf78stz	257	22	this	this	DT
cord-356188-rwf78stz	257	23	can	can	MD
cord-356188-rwf78stz	257	24	have	have	VB
cord-356188-rwf78stz	257	25	a	a	DT
cord-356188-rwf78stz	257	26	negative	negative	JJ
cord-356188-rwf78stz	257	27	impact	impact	NN
cord-356188-rwf78stz	257	28	on	on	IN
cord-356188-rwf78stz	257	29	immunization	immunization	NN
cord-356188-rwf78stz	257	30	efficacy	efficacy	NN
cord-356188-rwf78stz	257	31	[	[	-LRB-
cord-356188-rwf78stz	257	32	111	111	CD
cord-356188-rwf78stz	257	33	]	]	-RRB-
cord-356188-rwf78stz	257	34	[	[	-LRB-
cord-356188-rwf78stz	257	35	112	112	CD
cord-356188-rwf78stz	257	36	]	]	-RRB-
cord-356188-rwf78stz	257	37	[	[	-LRB-
cord-356188-rwf78stz	257	38	113	113	CD
cord-356188-rwf78stz	257	39	]	]	-RRB-
cord-356188-rwf78stz	257	40	.	.	.
cord-356188-rwf78stz	258	1	However	however	RB
cord-356188-rwf78stz	258	2	,	,	,
cord-356188-rwf78stz	258	3	prevaccination	prevaccination	NN
cord-356188-rwf78stz	258	4	T	T	NNP
cord-356188-rwf78stz	258	5	cell	cell	NN
cord-356188-rwf78stz	258	6	responses	response	NNS
cord-356188-rwf78stz	258	7	do	do	VBP
cord-356188-rwf78stz	258	8	not	not	RB
cord-356188-rwf78stz	258	9	correlate	correlate	VB
cord-356188-rwf78stz	258	10	with	with	IN
cord-356188-rwf78stz	258	11	postvaccination	postvaccination	NN
cord-356188-rwf78stz	258	12	antibody	antibody	NN
cord-356188-rwf78stz	258	13	titers	titer	NNS
cord-356188-rwf78stz	258	14	[	[	-LRB-
cord-356188-rwf78stz	258	15	114	114	CD
cord-356188-rwf78stz	258	16	]	]	-RRB-
cord-356188-rwf78stz	258	17	,	,	,
cord-356188-rwf78stz	258	18	and	and	CC
cord-356188-rwf78stz	258	19	as	as	IN
cord-356188-rwf78stz	258	20	the	the	DT
cord-356188-rwf78stz	258	21	elderly	elderly	JJ
cord-356188-rwf78stz	258	22	also	also	RB
cord-356188-rwf78stz	258	23	have	have	VBP
cord-356188-rwf78stz	258	24	decreased	decrease	VBN
cord-356188-rwf78stz	258	25	antibody	antibody	NN
cord-356188-rwf78stz	258	26	responses	response	NNS
cord-356188-rwf78stz	258	27	following	follow	VBG
cord-356188-rwf78stz	258	28	vaccination	vaccination	NN
cord-356188-rwf78stz	258	29	,	,	,
cord-356188-rwf78stz	258	30	T	t	NN
cord-356188-rwf78stz	258	31	cell	cell	NN
cord-356188-rwf78stz	258	32	responses	response	NNS
cord-356188-rwf78stz	258	33	may	may	MD
cord-356188-rwf78stz	258	34	provide	provide	VB
cord-356188-rwf78stz	258	35	a	a	DT
cord-356188-rwf78stz	258	36	better	well	JJR
cord-356188-rwf78stz	258	37	correlate	correlate	NN
cord-356188-rwf78stz	258	38	of	of	IN
cord-356188-rwf78stz	258	39	vaccine	vaccine	NN
cord-356188-rwf78stz	258	40	efficacy	efficacy	NN
cord-356188-rwf78stz	258	41	in	in	IN
cord-356188-rwf78stz	258	42	the	the	DT
cord-356188-rwf78stz	258	43	elderly	elderly	JJ
cord-356188-rwf78stz	258	44	population	population	NN
cord-356188-rwf78stz	258	45	[	[	-LRB-
cord-356188-rwf78stz	258	46	115	115	CD
cord-356188-rwf78stz	258	47	]	]	-RRB-
cord-356188-rwf78stz	258	48	.	.	.
cord-356188-rwf78stz	259	1	Interestingly	interestingly	RB
cord-356188-rwf78stz	259	2	,	,	,
cord-356188-rwf78stz	259	3	unstimulated	unstimulated	JJ
cord-356188-rwf78stz	259	4	memory	memory	NN
cord-356188-rwf78stz	259	5	T	T	NNP
cord-356188-rwf78stz	259	6	cells	cell	NNS
cord-356188-rwf78stz	259	7	from	from	IN
cord-356188-rwf78stz	259	8	older	old	JJR
cord-356188-rwf78stz	259	9	individuals	individual	NNS
cord-356188-rwf78stz	259	10	are	be	VBP
cord-356188-rwf78stz	259	11	in	in	IN
cord-356188-rwf78stz	259	12	a	a	DT
cord-356188-rwf78stz	259	13	higher	high	JJR
cord-356188-rwf78stz	259	14	state	state	NN
cord-356188-rwf78stz	259	15	of	of	IN
cord-356188-rwf78stz	259	16	differentiation	differentiation	NN
cord-356188-rwf78stz	259	17	than	than	IN
cord-356188-rwf78stz	259	18	those	those	DT
cord-356188-rwf78stz	259	19	of	of	IN
cord-356188-rwf78stz	259	20	younger	young	JJR
cord-356188-rwf78stz	259	21	individuals	individual	NNS
cord-356188-rwf78stz	259	22	,	,	,
cord-356188-rwf78stz	259	23	and	and	CC
cord-356188-rwf78stz	259	24	it	-PRON-	PRP
cord-356188-rwf78stz	259	25	was	be	VBD
cord-356188-rwf78stz	259	26	shown	show	VBN
cord-356188-rwf78stz	259	27	that	that	IN
cord-356188-rwf78stz	259	28	fewer	few	JJR
cord-356188-rwf78stz	259	29	senescent	senescent	JJ
cord-356188-rwf78stz	259	30	,	,	,
cord-356188-rwf78stz	259	31	influenza	influenza	NN
cord-356188-rwf78stz	259	32	-	-	HYPH
cord-356188-rwf78stz	259	33	specific	specific	JJ
cord-356188-rwf78stz	259	34	T	t	NN
cord-356188-rwf78stz	259	35	cells	cell	NNS
cord-356188-rwf78stz	259	36	,	,	,
cord-356188-rwf78stz	259	37	characterized	characterize	VBN
cord-356188-rwf78stz	259	38	as	as	IN
cord-356188-rwf78stz	259	39	killer	killer	NN
cord-356188-rwf78stz	259	40	cell	cell	NN
cord-356188-rwf78stz	259	41	lectin	lectin	NN
cord-356188-rwf78stz	259	42	-	-	HYPH
cord-356188-rwf78stz	259	43	like	like	JJ
cord-356188-rwf78stz	259	44	receptor	receptor	NN
cord-356188-rwf78stz	259	45	subfamily	subfamily	NN
cord-356188-rwf78stz	259	46	G	g	NN
cord-356188-rwf78stz	259	47	member	member	NN
cord-356188-rwf78stz	259	48	1	1	CD
cord-356188-rwf78stz	259	49	(	(	-LRB-
cord-356188-rwf78stz	259	50	KLRG1	KLRG1	NNP
cord-356188-rwf78stz	259	51	)	)	-RRB-
cord-356188-rwf78stz	260	1	hi	hi	UH
cord-356188-rwf78stz	260	2	CD57	CD57	NNP
cord-356188-rwf78stz	260	3	hi	hi	UH
cord-356188-rwf78stz	260	4	,	,	,
cord-356188-rwf78stz	260	5	are	be	VBP
cord-356188-rwf78stz	260	6	associated	associate	VBN
cord-356188-rwf78stz	260	7	with	with	IN
cord-356188-rwf78stz	260	8	a	a	DT
cord-356188-rwf78stz	260	9	more	more	RBR
cord-356188-rwf78stz	260	10	robust	robust	JJ
cord-356188-rwf78stz	260	11	antibody	antibody	NN
cord-356188-rwf78stz	260	12	response	response	NN
cord-356188-rwf78stz	260	13	following	follow	VBG
cord-356188-rwf78stz	260	14	TIV	TIV	NNP
cord-356188-rwf78stz	260	15	delivery	delivery	NN
cord-356188-rwf78stz	260	16	[	[	-LRB-
cord-356188-rwf78stz	260	17	110	110	CD
cord-356188-rwf78stz	260	18	]	]	-RRB-
cord-356188-rwf78stz	260	19	.	.	.
cord-356188-rwf78stz	261	1	The	the	DT
cord-356188-rwf78stz	261	2	immunodominance	immunodominance	NN
cord-356188-rwf78stz	261	3	hierarchy	hierarchy	NN
cord-356188-rwf78stz	261	4	in	in	IN
cord-356188-rwf78stz	261	5	HLA	HLA	NNP
cord-356188-rwf78stz	261	6	-	-	HYPH
cord-356188-rwf78stz	261	7	A*02	A*02	NNP
cord-356188-rwf78stz	261	8	individuals	individual	NNS
cord-356188-rwf78stz	261	9	is	be	VBZ
cord-356188-rwf78stz	261	10	often	often	RB
cord-356188-rwf78stz	261	11	reported	report	VBN
cord-356188-rwf78stz	261	12	as	as	IN
cord-356188-rwf78stz	261	13	directed	direct	VBN
cord-356188-rwf78stz	261	14	primarily	primarily	RB
cord-356188-rwf78stz	261	15	against	against	IN
cord-356188-rwf78stz	261	16	the	the	DT
cord-356188-rwf78stz	261	17	conserved	conserve	VBN
cord-356188-rwf78stz	261	18	influenza	influenza	NN
cord-356188-rwf78stz	261	19	A	a	DT
cord-356188-rwf78stz	261	20	M1	M1	NNP
cord-356188-rwf78stz	261	21	58	58	CD
cord-356188-rwf78stz	261	22	-66	-66	NFP
cord-356188-rwf78stz	261	23	(	(	-LRB-
cord-356188-rwf78stz	261	24	GILGFVFTL	GILGFVFTL	NNP
cord-356188-rwf78stz	261	25	)	)	-RRB-
cord-356188-rwf78stz	261	26	[	[	-LRB-
cord-356188-rwf78stz	261	27	198	198	CD
cord-356188-rwf78stz	261	28	,	,	,
cord-356188-rwf78stz	261	29	199	199	CD
cord-356188-rwf78stz	261	30	]	]	-RRB-
cord-356188-rwf78stz	261	31	.	.	.
cord-356188-rwf78stz	262	1	However	however	RB
cord-356188-rwf78stz	262	2	,	,	,
cord-356188-rwf78stz	262	3	studies	study	NNS
cord-356188-rwf78stz	262	4	suggest	suggest	VBP
cord-356188-rwf78stz	262	5	that	that	IN
cord-356188-rwf78stz	262	6	although	although	IN
cord-356188-rwf78stz	262	7	this	this	DT
cord-356188-rwf78stz	262	8	CD8	CD8	NNP
cord-356188-rwf78stz	262	9	ϩ	ϩ	WDT
cord-356188-rwf78stz	262	10	T	T	NNP
cord-356188-rwf78stz	262	11	cell	cell	NN
cord-356188-rwf78stz	262	12	response	response	NN
cord-356188-rwf78stz	262	13	to	to	IN
cord-356188-rwf78stz	262	14	M1	M1	NNP
cord-356188-rwf78stz	262	15	58	58	CD
cord-356188-rwf78stz	262	16	-66	-66	NFP
cord-356188-rwf78stz	262	17	is	be	VBZ
cord-356188-rwf78stz	262	18	conserved	conserve	VBN
cord-356188-rwf78stz	262	19	in	in	IN
cord-356188-rwf78stz	262	20	HLA	HLA	NNP
cord-356188-rwf78stz	262	21	-	-	HYPH
cord-356188-rwf78stz	262	22	A*02	A*02	NNP
cord-356188-rwf78stz	262	23	individuals	individual	NNS
cord-356188-rwf78stz	262	24	,	,	,
cord-356188-rwf78stz	262	25	it	-PRON-	PRP
cord-356188-rwf78stz	262	26	may	may	MD
cord-356188-rwf78stz	262	27	not	not	RB
cord-356188-rwf78stz	262	28	be	be	VB
cord-356188-rwf78stz	262	29	strictly	strictly	RB
cord-356188-rwf78stz	262	30	immunodominant	immunodominant	JJ
cord-356188-rwf78stz	262	31	,	,	,
cord-356188-rwf78stz	262	32	as	as	IN
cord-356188-rwf78stz	262	33	greater	great	JJR
cord-356188-rwf78stz	262	34	responses	response	NNS
cord-356188-rwf78stz	262	35	were	be	VBD
cord-356188-rwf78stz	262	36	observed	observe	VBN
cord-356188-rwf78stz	262	37	against	against	IN
cord-356188-rwf78stz	262	38	internal	internal	JJ
cord-356188-rwf78stz	262	39	NP	NP	NNP
cord-356188-rwf78stz	262	40	and	and	CC
cord-356188-rwf78stz	262	41	polymerase	polymerase	NN
cord-356188-rwf78stz	262	42	PB1	pb1	NN
cord-356188-rwf78stz	262	43	subunit	subunit	NN
cord-356188-rwf78stz	262	44	proteins	protein	NNS
cord-356188-rwf78stz	262	45	in	in	IN
cord-356188-rwf78stz	262	46	some	some	DT
cord-356188-rwf78stz	262	47	individuals	individual	NNS
cord-356188-rwf78stz	262	48	[	[	-LRB-
cord-356188-rwf78stz	262	49	122	122	CD
cord-356188-rwf78stz	262	50	,	,	,
cord-356188-rwf78stz	262	51	200	200	CD
cord-356188-rwf78stz	262	52	]	]	-RRB-
cord-356188-rwf78stz	262	53	.	.	.
cord-356188-rwf78stz	263	1	In	in	IN
cord-356188-rwf78stz	263	2	terms	term	NNS
cord-356188-rwf78stz	263	3	of	of	IN
cord-356188-rwf78stz	263	4	HLA	HLA	NNP
cord-356188-rwf78stz	263	5	presentation	presentation	NN
cord-356188-rwf78stz	263	6	of	of	IN
cord-356188-rwf78stz	263	7	influenza	influenza	NN
cord-356188-rwf78stz	263	8	peptides	peptide	NNS
cord-356188-rwf78stz	263	9	,	,	,
cord-356188-rwf78stz	263	10	the	the	DT
cord-356188-rwf78stz	263	11	HLA	HLA	NNP
cord-356188-rwf78stz	263	12	-	-	HYPH
cord-356188-rwf78stz	263	13	A*02:01-restricted	A*02:01-restricted	NNP
cord-356188-rwf78stz	263	14	M1	M1	NNP
cord-356188-rwf78stz	263	15	58	58	CD
cord-356188-rwf78stz	263	16	-66	-66	CD
cord-356188-rwf78stz	263	17	peptide	peptide	NN
cord-356188-rwf78stz	263	18	-	-	HYPH
cord-356188-rwf78stz	263	19	specific	specific	JJ
cord-356188-rwf78stz	263	20	CTL	CTL	NNP
cord-356188-rwf78stz	263	21	response	response	NN
cord-356188-rwf78stz	263	22	is	be	VBZ
cord-356188-rwf78stz	263	23	characterized	characterize	VBN
cord-356188-rwf78stz	263	24	by	by	IN
cord-356188-rwf78stz	263	25	expression	expression	NN
cord-356188-rwf78stz	263	26	of	of	IN
cord-356188-rwf78stz	263	27	V	V	NNP
cord-356188-rwf78stz	263	28	␤	␤	NNP
cord-356188-rwf78stz	263	29	17	17	CD
cord-356188-rwf78stz	263	30	TCR	TCR	NNP
cord-356188-rwf78stz	263	31	use	use	VBP
cord-356188-rwf78stz	263	32	[	[	-LRB-
cord-356188-rwf78stz	263	33	201	201	CD
cord-356188-rwf78stz	263	34	]	]	-RRB-
cord-356188-rwf78stz	263	35	,	,	,
cord-356188-rwf78stz	263	36	and	and	CC
cord-356188-rwf78stz	263	37	in	in	IN
cord-356188-rwf78stz	263	38	HLA	HLA	NNP
cord-356188-rwf78stz	263	39	-	-	HYPH
cord-356188-rwf78stz	263	40	A*02:01	a*02:01	NN
cord-356188-rwf78stz	263	41	individuals	individual	NNS
cord-356188-rwf78stz	263	42	,	,	,
cord-356188-rwf78stz	263	43	V	V	NNP
cord-356188-rwf78stz	263	44	␤	␤	CD
cord-356188-rwf78stz	263	45	17	17	CD
cord-356188-rwf78stz	263	46	ϩ	ϩ	NN
cord-356188-rwf78stz	263	47	CTLs	ctl	NNS
cord-356188-rwf78stz	263	48	were	be	VBD
cord-356188-rwf78stz	263	49	the	the	DT
cord-356188-rwf78stz	263	50	dominant	dominant	JJ
cord-356188-rwf78stz	263	51	cells	cell	NNS
cord-356188-rwf78stz	263	52	responding	respond	VBG
cord-356188-rwf78stz	263	53	to	to	IN
cord-356188-rwf78stz	263	54	in	in	FW
cord-356188-rwf78stz	263	55	vitro	vitro	FW
cord-356188-rwf78stz	263	56	influenza	influenza	NN
cord-356188-rwf78stz	263	57	exposure	exposure	NN
cord-356188-rwf78stz	263	58	.	.	.
cord-356188-rwf78stz	264	1	In	in	IN
cord-356188-rwf78stz	264	2	contrast	contrast	NN
cord-356188-rwf78stz	264	3	,	,	,
cord-356188-rwf78stz	264	4	cord	cord	NN
cord-356188-rwf78stz	264	5	blood	blood	NN
cord-356188-rwf78stz	264	6	from	from	IN
cord-356188-rwf78stz	264	7	HLA	HLA	NNP
cord-356188-rwf78stz	264	8	-	-	HYPH
cord-356188-rwf78stz	264	9	A*02:01	a*02:01	JJ
cord-356188-rwf78stz	264	10	infants	infant	NNS
cord-356188-rwf78stz	264	11	,	,	,
cord-356188-rwf78stz	264	12	thus	thus	RB
cord-356188-rwf78stz	264	13	having	have	VBG
cord-356188-rwf78stz	264	14	no	no	DT
cord-356188-rwf78stz	264	15	prior	prior	JJ
cord-356188-rwf78stz	264	16	influenza	influenza	NN
cord-356188-rwf78stz	264	17	exposure	exposure	NN
cord-356188-rwf78stz	264	18	,	,	,
cord-356188-rwf78stz	264	19	was	be	VBD
cord-356188-rwf78stz	264	20	characterized	characterize	VBN
cord-356188-rwf78stz	264	21	by	by	IN
cord-356188-rwf78stz	264	22	a	a	DT
cord-356188-rwf78stz	264	23	M1	M1	NNP
cord-356188-rwf78stz	264	24	58	58	CD
cord-356188-rwf78stz	264	25	-66	-66	SYM
cord-356188-rwf78stz	264	26	-specific	-specific	NFP
cord-356188-rwf78stz	264	27	CD8	CD8	NNP
cord-356188-rwf78stz	264	28	ϩ	ϩ	NNP
cord-356188-rwf78stz	264	29	T	T	NNP
cord-356188-rwf78stz	264	30	cell	cell	NN
cord-356188-rwf78stz	264	31	response	response	NN
cord-356188-rwf78stz	264	32	that	that	WDT
cord-356188-rwf78stz	264	33	was	be	VBD
cord-356188-rwf78stz	264	34	less	less	RBR
cord-356188-rwf78stz	264	35	dependent	dependent	JJ
cord-356188-rwf78stz	264	36	on	on	IN
cord-356188-rwf78stz	264	37	the	the	DT
cord-356188-rwf78stz	264	38	presence	presence	NN
cord-356188-rwf78stz	264	39	of	of	IN
cord-356188-rwf78stz	264	40	the	the	DT
cord-356188-rwf78stz	264	41	CD8	CD8	NNP
cord-356188-rwf78stz	265	1	ϩ	ϩ	NN
cord-356188-rwf78stz	265	2	V	V	NNP
cord-356188-rwf78stz	265	3	␤	␤	CD
cord-356188-rwf78stz	265	4	17	17	CD
cord-356188-rwf78stz	266	1	ϩ	ϩ	LS
cord-356188-rwf78stz	266	2	T	T	NNP
cord-356188-rwf78stz	266	3	cell	cell	NN
cord-356188-rwf78stz	266	4	population	population	NN
cord-356188-rwf78stz	266	5	[	[	-LRB-
cord-356188-rwf78stz	266	6	109	109	CD
cord-356188-rwf78stz	266	7	]	]	-RRB-
cord-356188-rwf78stz	266	8	.	.	.
cord-356188-rwf78stz	267	1	Therefore	therefore	RB
cord-356188-rwf78stz	267	2	,	,	,
cord-356188-rwf78stz	267	3	maturation	maturation	NN
cord-356188-rwf78stz	267	4	of	of	IN
cord-356188-rwf78stz	267	5	the	the	DT
cord-356188-rwf78stz	267	6	CTL	CTL	NNP
cord-356188-rwf78stz	267	7	response	response	NN
cord-356188-rwf78stz	267	8	upon	upon	IN
cord-356188-rwf78stz	267	9	subsequent	subsequent	JJ
cord-356188-rwf78stz	267	10	influenza	influenza	NN
cord-356188-rwf78stz	267	11	infections	infection	NNS
cord-356188-rwf78stz	267	12	is	be	VBZ
cord-356188-rwf78stz	267	13	likely	likely	RB
cord-356188-rwf78stz	267	14	related	relate	VBN
cord-356188-rwf78stz	267	15	to	to	IN
cord-356188-rwf78stz	267	16	effective	effective	JJ
cord-356188-rwf78stz	267	17	clearance	clearance	NN
cord-356188-rwf78stz	267	18	of	of	IN
cord-356188-rwf78stz	267	19	viral	viral	JJ
cord-356188-rwf78stz	267	20	infections	infection	NNS
cord-356188-rwf78stz	267	21	and	and	CC
cord-356188-rwf78stz	267	22	has	have	VBZ
cord-356188-rwf78stz	267	23	important	important	JJ
cord-356188-rwf78stz	267	24	implications	implication	NNS
cord-356188-rwf78stz	267	25	for	for	IN
cord-356188-rwf78stz	267	26	therapeutic	therapeutic	JJ
cord-356188-rwf78stz	267	27	interventions	intervention	NNS
cord-356188-rwf78stz	267	28	.	.	.
cord-356188-rwf78stz	268	1	Although	although	IN
cord-356188-rwf78stz	268	2	children	child	NNS
cord-356188-rwf78stz	268	3	beyond	beyond	IN
cord-356188-rwf78stz	268	4	infancy	infancy	NN
cord-356188-rwf78stz	268	5	who	who	WP
cord-356188-rwf78stz	268	6	are	be	VBP
cord-356188-rwf78stz	268	7	considered	consider	VBN
cord-356188-rwf78stz	268	8	high	high	JJ
cord-356188-rwf78stz	268	9	-	-	HYPH
cord-356188-rwf78stz	268	10	risk	risk	NN
cord-356188-rwf78stz	268	11	for	for	IN
cord-356188-rwf78stz	268	12	influenza	influenza	NN
cord-356188-rwf78stz	268	13	infection	infection	NN
cord-356188-rwf78stz	268	14	,	,	,
cord-356188-rwf78stz	268	15	i.e.	i.e.	FW
cord-356188-rwf78stz	268	16	,	,	,
cord-356188-rwf78stz	268	17	children	child	NNS
cord-356188-rwf78stz	268	18	with	with	IN
cord-356188-rwf78stz	268	19	underlying	underlie	VBG
cord-356188-rwf78stz	268	20	diseases	disease	NNS
cord-356188-rwf78stz	268	21	,	,	,
cord-356188-rwf78stz	268	22	such	such	JJ
cord-356188-rwf78stz	268	23	as	as	IN
cord-356188-rwf78stz	268	24	asthma	asthma	NN
cord-356188-rwf78stz	268	25	,	,	,
cord-356188-rwf78stz	268	26	sickle	sickle	NN
cord-356188-rwf78stz	268	27	cell	cell	NN
cord-356188-rwf78stz	268	28	disease	disease	NN
cord-356188-rwf78stz	268	29	,	,	,
cord-356188-rwf78stz	268	30	and	and	CC
cord-356188-rwf78stz	268	31	those	those	DT
cord-356188-rwf78stz	268	32	receiving	receive	VBG
cord-356188-rwf78stz	268	33	solid	solid	JJ
cord-356188-rwf78stz	268	34	organ	organ	NN
cord-356188-rwf78stz	268	35	transplantation	transplantation	NN
cord-356188-rwf78stz	268	36	,	,	,
cord-356188-rwf78stz	268	37	have	have	VBP
cord-356188-rwf78stz	268	38	sig	sig	VBN
cord-356188-rwf78stz	268	39	-	-	HYPH
cord-356188-rwf78stz	268	40	nificant	nificant	JJ
cord-356188-rwf78stz	268	41	increases	increase	NNS
cord-356188-rwf78stz	268	42	in	in	IN
cord-356188-rwf78stz	268	43	serum	serum	NN
cord-356188-rwf78stz	268	44	nAb	nAb	NNS
cord-356188-rwf78stz	268	45	and	and	CC
cord-356188-rwf78stz	268	46	T	T	NNP
cord-356188-rwf78stz	268	47	cell	cell	NN
cord-356188-rwf78stz	268	48	responses	response	NNS
cord-356188-rwf78stz	268	49	,	,	,
cord-356188-rwf78stz	268	50	children	child	NNS
cord-356188-rwf78stz	268	51	with	with	IN
cord-356188-rwf78stz	268	52	systemic	systemic	JJ
cord-356188-rwf78stz	268	53	lupus	lupus	NN
cord-356188-rwf78stz	268	54	erythematosus	erythematosus	NN
cord-356188-rwf78stz	268	55	are	be	VBP
cord-356188-rwf78stz	268	56	unable	unable	JJ
cord-356188-rwf78stz	268	57	to	to	TO
cord-356188-rwf78stz	268	58	mount	mount	VB
cord-356188-rwf78stz	268	59	significant	significant	JJ
cord-356188-rwf78stz	268	60	T	T	NNP
cord-356188-rwf78stz	268	61	cell	cell	NN
cord-356188-rwf78stz	268	62	responses	response	NNS
cord-356188-rwf78stz	268	63	following	follow	VBG
cord-356188-rwf78stz	268	64	TIV	TIV	NNP
cord-356188-rwf78stz	268	65	immunization	immunization	NN
cord-356188-rwf78stz	268	66	[	[	-LRB-
cord-356188-rwf78stz	268	67	108	108	CD
cord-356188-rwf78stz	268	68	]	]	-RRB-
cord-356188-rwf78stz	268	69	.	.	.
cord-356188-rwf78stz	269	1	These	these	DT
cord-356188-rwf78stz	269	2	findings	finding	NNS
cord-356188-rwf78stz	269	3	suggest	suggest	VBP
cord-356188-rwf78stz	269	4	that	that	IN
cord-356188-rwf78stz	269	5	the	the	DT
cord-356188-rwf78stz	269	6	pathogenesis	pathogenesis	NN
cord-356188-rwf78stz	269	7	of	of	IN
cord-356188-rwf78stz	269	8	respiratory	respiratory	JJ
cord-356188-rwf78stz	269	9	viral	viral	JJ
cord-356188-rwf78stz	269	10	infections	infection	NNS
cord-356188-rwf78stz	269	11	in	in	IN
cord-356188-rwf78stz	269	12	infants	infant	NNS
cord-356188-rwf78stz	269	13	may	may	MD
cord-356188-rwf78stz	269	14	be	be	VB
cord-356188-rwf78stz	269	15	associated	associate	VBN
cord-356188-rwf78stz	269	16	with	with	IN
cord-356188-rwf78stz	269	17	the	the	DT
cord-356188-rwf78stz	269	18	absence	absence	NN
cord-356188-rwf78stz	269	19	of	of	IN
cord-356188-rwf78stz	269	20	immunological	immunological	JJ
cord-356188-rwf78stz	269	21	memory	memory	NN
cord-356188-rwf78stz	269	22	or	or	CC
cord-356188-rwf78stz	269	23	a	a	DT
cord-356188-rwf78stz	269	24	failure	failure	NN
cord-356188-rwf78stz	269	25	to	to	TO
cord-356188-rwf78stz	269	26	develop	develop	VB
cord-356188-rwf78stz	269	27	an	an	DT
cord-356188-rwf78stz	269	28	appropriate	appropriate	JJ
cord-356188-rwf78stz	269	29	,	,	,
cord-356188-rwf78stz	269	30	well	well	RB
cord-356188-rwf78stz	269	31	-	-	HYPH
cord-356188-rwf78stz	269	32	regulated	regulate	VBN
cord-356188-rwf78stz	269	33	T	T	NNP
cord-356188-rwf78stz	269	34	cell	cell	NN
cord-356188-rwf78stz	269	35	response	response	NN
cord-356188-rwf78stz	269	36	.	.	.
cord-356188-rwf78stz	270	1	Undoubtedly	undoubtedly	RB
cord-356188-rwf78stz	270	2	,	,	,
cord-356188-rwf78stz	270	3	host	host	NN
cord-356188-rwf78stz	270	4	genetics	genetic	NNS
cord-356188-rwf78stz	270	5	have	have	VBP
cord-356188-rwf78stz	270	6	a	a	DT
cord-356188-rwf78stz	270	7	role	role	NN
cord-356188-rwf78stz	270	8	in	in	IN
cord-356188-rwf78stz	270	9	the	the	DT
cord-356188-rwf78stz	270	10	outcome	outcome	NN
cord-356188-rwf78stz	270	11	of	of	IN
cord-356188-rwf78stz	270	12	many	many	JJ
cord-356188-rwf78stz	270	13	infectious	infectious	JJ
cord-356188-rwf78stz	270	14	diseases	disease	NNS
cord-356188-rwf78stz	270	15	,	,	,
cord-356188-rwf78stz	270	16	including	include	VBG
cord-356188-rwf78stz	270	17	influenza	influenza	NN
cord-356188-rwf78stz	270	18	.	.	.
cord-356188-rwf78stz	271	1	Mouse	mouse	NN
cord-356188-rwf78stz	271	2	models	model	NNS
cord-356188-rwf78stz	271	3	have	have	VBP
cord-356188-rwf78stz	271	4	provided	provide	VBN
cord-356188-rwf78stz	271	5	some	some	DT
cord-356188-rwf78stz	271	6	clues	clue	NNS
cord-356188-rwf78stz	271	7	regarding	regard	VBG
cord-356188-rwf78stz	271	8	the	the	DT
cord-356188-rwf78stz	271	9	role	role	NN
cord-356188-rwf78stz	271	10	of	of	IN
cord-356188-rwf78stz	271	11	the	the	DT
cord-356188-rwf78stz	271	12	host	host	NN
cord-356188-rwf78stz	271	13	genetic	genetic	JJ
cord-356188-rwf78stz	271	14	component	component	NN
cord-356188-rwf78stz	271	15	on	on	IN
cord-356188-rwf78stz	271	16	the	the	DT
cord-356188-rwf78stz	271	17	inflammatory	inflammatory	JJ
cord-356188-rwf78stz	271	18	response	response	NN
cord-356188-rwf78stz	271	19	in	in	IN
cord-356188-rwf78stz	271	20	the	the	DT
cord-356188-rwf78stz	271	21	respiratory	respiratory	JJ
cord-356188-rwf78stz	271	22	tract	tract	NN
cord-356188-rwf78stz	271	23	.	.	.
cord-356188-rwf78stz	272	1	Briefly	briefly	RB
cord-356188-rwf78stz	272	2	,	,	,
cord-356188-rwf78stz	272	3	these	these	DT
cord-356188-rwf78stz	272	4	studies	study	NNS
cord-356188-rwf78stz	272	5	found	find	VBD
cord-356188-rwf78stz	272	6	that	that	IN
cord-356188-rwf78stz	272	7	influenza	influenza	NN
cord-356188-rwf78stz	272	8	-	-	HYPH
cord-356188-rwf78stz	272	9	induced	induce	VBN
cord-356188-rwf78stz	272	10	pathology	pathology	NN
cord-356188-rwf78stz	272	11	is	be	VBZ
cord-356188-rwf78stz	272	12	altered	alter	VBN
cord-356188-rwf78stz	272	13	depending	depend	VBG
cord-356188-rwf78stz	272	14	on	on	IN
cord-356188-rwf78stz	272	15	the	the	DT
cord-356188-rwf78stz	272	16	inbred	inbred	JJ
cord-356188-rwf78stz	272	17	mouse	mouse	NN
cord-356188-rwf78stz	272	18	strain	strain	NN
cord-356188-rwf78stz	272	19	used	use	VBN
cord-356188-rwf78stz	272	20	for	for	IN
cord-356188-rwf78stz	272	21	infection	infection	NN
cord-356188-rwf78stz	272	22	.	.	.
cord-356188-rwf78stz	273	1	The	the	DT
cord-356188-rwf78stz	273	2	genetic	genetic	JJ
cord-356188-rwf78stz	273	3	background	background	NN
cord-356188-rwf78stz	273	4	of	of	IN
cord-356188-rwf78stz	273	5	the	the	DT
cord-356188-rwf78stz	273	6	host	host	NN
cord-356188-rwf78stz	273	7	also	also	RB
cord-356188-rwf78stz	273	8	controls	control	VBZ
cord-356188-rwf78stz	273	9	cumulative	cumulative	JJ
cord-356188-rwf78stz	273	10	and	and	CC
cord-356188-rwf78stz	273	11	maximal	maximal	JJ
cord-356188-rwf78stz	273	12	viral	viral	JJ
cord-356188-rwf78stz	273	13	titer	titer	NN
cord-356188-rwf78stz	273	14	,	,	,
cord-356188-rwf78stz	273	15	underscoring	underscore	VBG
cord-356188-rwf78stz	273	16	the	the	DT
cord-356188-rwf78stz	273	17	importance	importance	NN
cord-356188-rwf78stz	273	18	of	of	IN
cord-356188-rwf78stz	273	19	limiting	limit	VBG
cord-356188-rwf78stz	273	20	viral	viral	JJ
cord-356188-rwf78stz	273	21	replication	replication	NN
cord-356188-rwf78stz	273	22	early	early	RB
cord-356188-rwf78stz	273	23	during	during	IN
cord-356188-rwf78stz	273	24	influenza	influenza	NN
cord-356188-rwf78stz	273	25	infection	infection	NN
cord-356188-rwf78stz	273	26	[	[	-LRB-
cord-356188-rwf78stz	273	27	111	111	CD
cord-356188-rwf78stz	273	28	,	,	,
cord-356188-rwf78stz	273	29	202	202	CD
cord-356188-rwf78stz	273	30	]	]	-RRB-
cord-356188-rwf78stz	273	31	.	.	.
cord-356188-rwf78stz	274	1	In	in	IN
cord-356188-rwf78stz	274	2	humans	human	NNS
cord-356188-rwf78stz	274	3	,	,	,
cord-356188-rwf78stz	274	4	certain	certain	JJ
cord-356188-rwf78stz	274	5	populations	population	NNS
cord-356188-rwf78stz	274	6	worldwide	worldwide	RB
cord-356188-rwf78stz	274	7	have	have	VBP
cord-356188-rwf78stz	274	8	been	be	VBN
cord-356188-rwf78stz	274	9	found	find	VBN
cord-356188-rwf78stz	274	10	to	to	TO
cord-356188-rwf78stz	274	11	be	be	VB
cord-356188-rwf78stz	274	12	more	more	RBR
cord-356188-rwf78stz	274	13	prone	prone	JJ
cord-356188-rwf78stz	274	14	to	to	IN
cord-356188-rwf78stz	274	15	severe	severe	JJ
cord-356188-rwf78stz	274	16	disease	disease	NN
cord-356188-rwf78stz	274	17	during	during	IN
cord-356188-rwf78stz	274	18	influenza	influenza	NN
cord-356188-rwf78stz	274	19	infection	infection	NN
cord-356188-rwf78stz	274	20	.	.	.
cord-356188-rwf78stz	275	1	For	for	IN
cord-356188-rwf78stz	275	2	instance	instance	NN
cord-356188-rwf78stz	275	3	,	,	,
cord-356188-rwf78stz	275	4	Aboriginal	aboriginal	JJ
cord-356188-rwf78stz	275	5	peoples	people	NNS
cord-356188-rwf78stz	275	6	have	have	VBP
cord-356188-rwf78stz	275	7	more	more	RBR
cord-356188-rwf78stz	275	8	severe	severe	JJ
cord-356188-rwf78stz	275	9	illness	illness	NN
cord-356188-rwf78stz	275	10	and	and	CC
cord-356188-rwf78stz	275	11	increased	increase	VBN
cord-356188-rwf78stz	275	12	mortality	mortality	NN
cord-356188-rwf78stz	275	13	during	during	IN
cord-356188-rwf78stz	275	14	the	the	DT
cord-356188-rwf78stz	275	15	A	A	NNP
cord-356188-rwf78stz	275	16	/	/	SYM
cord-356188-rwf78stz	275	17	H1N1	H1N1	NNP
cord-356188-rwf78stz	275	18	pandemics	pandemic	NNS
cord-356188-rwf78stz	275	19	of	of	IN
cord-356188-rwf78stz	275	20	1918	1918	CD
cord-356188-rwf78stz	275	21	and	and	CC
cord-356188-rwf78stz	275	22	2009	2009	CD
cord-356188-rwf78stz	275	23	compared	compare	VBN
cord-356188-rwf78stz	275	24	with	with	IN
cord-356188-rwf78stz	275	25	those	those	DT
cord-356188-rwf78stz	275	26	of	of	IN
cord-356188-rwf78stz	275	27	non	non	JJ
cord-356188-rwf78stz	275	28	-	-	JJ
cord-356188-rwf78stz	275	29	Aboriginal	aboriginal	JJ
cord-356188-rwf78stz	275	30	descent	descent	NN
cord-356188-rwf78stz	275	31	[	[	-LRB-
cord-356188-rwf78stz	275	32	29	29	CD
cord-356188-rwf78stz	275	33	,	,	,
cord-356188-rwf78stz	275	34	116	116	CD
cord-356188-rwf78stz	275	35	-118	-118	NN
cord-356188-rwf78stz	275	36	]	]	-RRB-
cord-356188-rwf78stz	275	37	.	.	.
cord-356188-rwf78stz	276	1	It	-PRON-	PRP
cord-356188-rwf78stz	276	2	is	be	VBZ
cord-356188-rwf78stz	276	3	important	important	JJ
cord-356188-rwf78stz	276	4	to	to	TO
cord-356188-rwf78stz	276	5	note	note	VB
cord-356188-rwf78stz	276	6	,	,	,
cord-356188-rwf78stz	276	7	however	however	RB
cord-356188-rwf78stz	276	8	,	,	,
cord-356188-rwf78stz	276	9	that	that	IN
cord-356188-rwf78stz	276	10	poor	poor	JJ
cord-356188-rwf78stz	276	11	socioeconomic	socioeconomic	JJ
cord-356188-rwf78stz	276	12	conditions	condition	NNS
cord-356188-rwf78stz	276	13	and	and	CC
cord-356188-rwf78stz	276	14	metabolic	metabolic	JJ
cord-356188-rwf78stz	276	15	diseases	disease	NNS
cord-356188-rwf78stz	276	16	,	,	,
cord-356188-rwf78stz	276	17	such	such	JJ
cord-356188-rwf78stz	276	18	as	as	IN
cord-356188-rwf78stz	276	19	diabetes	diabetes	NN
cord-356188-rwf78stz	276	20	,	,	,
cord-356188-rwf78stz	276	21	are	be	VBP
cord-356188-rwf78stz	276	22	more	more	RBR
cord-356188-rwf78stz	276	23	common	common	JJ
cord-356188-rwf78stz	276	24	in	in	IN
cord-356188-rwf78stz	276	25	indigenous	indigenous	JJ
cord-356188-rwf78stz	276	26	populations	population	NNS
cord-356188-rwf78stz	276	27	[	[	-LRB-
cord-356188-rwf78stz	276	28	203	203	CD
cord-356188-rwf78stz	276	29	]	]	-RRB-
cord-356188-rwf78stz	276	30	,	,	,
cord-356188-rwf78stz	276	31	and	and	CC
cord-356188-rwf78stz	276	32	this	this	DT
cord-356188-rwf78stz	276	33	may	may	MD
cord-356188-rwf78stz	276	34	contribute	contribute	VB
cord-356188-rwf78stz	276	35	to	to	IN
cord-356188-rwf78stz	276	36	influenza	influenza	NN
cord-356188-rwf78stz	276	37	-	-	HYPH
cord-356188-rwf78stz	276	38	related	relate	VBN
cord-356188-rwf78stz	276	39	disease	disease	NN
cord-356188-rwf78stz	276	40	.	.	.
cord-356188-rwf78stz	277	1	Moreover	moreover	RB
cord-356188-rwf78stz	277	2	,	,	,
cord-356188-rwf78stz	277	3	HLA	HLA	NNP
cord-356188-rwf78stz	277	4	alleles	allele	NNS
cord-356188-rwf78stz	277	5	are	be	VBP
cord-356188-rwf78stz	277	6	proposed	propose	VBN
cord-356188-rwf78stz	277	7	to	to	TO
cord-356188-rwf78stz	277	8	have	have	VB
cord-356188-rwf78stz	277	9	some	some	DT
cord-356188-rwf78stz	277	10	role	role	NN
cord-356188-rwf78stz	277	11	during	during	IN
cord-356188-rwf78stz	277	12	influenza	influenza	NN
cord-356188-rwf78stz	277	13	infection	infection	NN
cord-356188-rwf78stz	277	14	,	,	,
cord-356188-rwf78stz	277	15	as	as	IN
cord-356188-rwf78stz	277	16	differential	differential	JJ
cord-356188-rwf78stz	277	17	CTL	CTL	NNP
cord-356188-rwf78stz	277	18	responses	response	NNS
cord-356188-rwf78stz	277	19	exist	exist	VBP
cord-356188-rwf78stz	277	20	in	in	IN
cord-356188-rwf78stz	277	21	individuals	individual	NNS
cord-356188-rwf78stz	277	22	with	with	IN
cord-356188-rwf78stz	277	23	varying	vary	VBG
cord-356188-rwf78stz	277	24	HLA	HLA	NNP
cord-356188-rwf78stz	277	25	alleles	allele	NNS
cord-356188-rwf78stz	277	26	[	[	-LRB-
cord-356188-rwf78stz	277	27	204	204	CD
cord-356188-rwf78stz	277	28	]	]	-RRB-
cord-356188-rwf78stz	277	29	.	.	.
cord-356188-rwf78stz	278	1	Gene	gene	NN
cord-356188-rwf78stz	278	2	polymorphisms	polymorphism	NNS
cord-356188-rwf78stz	278	3	located	locate	VBN
cord-356188-rwf78stz	278	4	in	in	IN
cord-356188-rwf78stz	278	5	human	human	JJ
cord-356188-rwf78stz	278	6	chromosomes	chromosome	NNS
cord-356188-rwf78stz	278	7	1	1	CD
cord-356188-rwf78stz	278	8	and	and	CC
cord-356188-rwf78stz	278	9	17	17	CD
cord-356188-rwf78stz	278	10	were	be	VBD
cord-356188-rwf78stz	278	11	also	also	RB
cord-356188-rwf78stz	278	12	determined	determined	JJ
cord-356188-rwf78stz	278	13	to	to	TO
cord-356188-rwf78stz	278	14	be	be	VB
cord-356188-rwf78stz	278	15	associated	associate	VBN
cord-356188-rwf78stz	278	16	with	with	IN
cord-356188-rwf78stz	278	17	severe	severe	JJ
cord-356188-rwf78stz	278	18	pneumonia	pneumonia	NN
cord-356188-rwf78stz	278	19	during	during	IN
cord-356188-rwf78stz	278	20	A(H1N1)pdm09	A(H1N1)pdm09	NNP
cord-356188-rwf78stz	278	21	infection	infection	NN
cord-356188-rwf78stz	278	22	[	[	-LRB-
cord-356188-rwf78stz	278	23	120	120	CD
cord-356188-rwf78stz	278	24	]	]	-RRB-
cord-356188-rwf78stz	278	25	.	.	.
cord-356188-rwf78stz	279	1	Interestingly	interestingly	RB
cord-356188-rwf78stz	279	2	,	,	,
cord-356188-rwf78stz	279	3	two	two	CD
cord-356188-rwf78stz	279	4	of	of	IN
cord-356188-rwf78stz	279	5	these	these	DT
cord-356188-rwf78stz	279	6	SNPs	snp	NNS
cord-356188-rwf78stz	279	7	are	be	VBP
cord-356188-rwf78stz	279	8	mapped	map	VBN
cord-356188-rwf78stz	279	9	to	to	IN
cord-356188-rwf78stz	279	10	genes	gene	NNS
cord-356188-rwf78stz	279	11	FCGR2A	fcgr2a	JJ
cord-356188-rwf78stz	279	12	and	and	CC
cord-356188-rwf78stz	279	13	C1QBP	C1QBP	NNP
cord-356188-rwf78stz	279	14	.	.	.
cord-356188-rwf78stz	280	1	The	the	DT
cord-356188-rwf78stz	280	2	protein	protein	NN
cord-356188-rwf78stz	280	3	encoded	encode	VBN
cord-356188-rwf78stz	280	4	by	by	IN
cord-356188-rwf78stz	280	5	FCGR2A	FCGR2A	NNP
cord-356188-rwf78stz	280	6	is	be	VBZ
cord-356188-rwf78stz	280	7	involved	involve	VBN
cord-356188-rwf78stz	280	8	in	in	IN
cord-356188-rwf78stz	280	9	phagocytosis	phagocytosis	NN
cord-356188-rwf78stz	280	10	and	and	CC
cord-356188-rwf78stz	280	11	clearance	clearance	NN
cord-356188-rwf78stz	280	12	of	of	IN
cord-356188-rwf78stz	280	13	immune	immune	JJ
cord-356188-rwf78stz	280	14	complexes	complex	NNS
cord-356188-rwf78stz	280	15	and	and	CC
cord-356188-rwf78stz	280	16	expressed	express	VBD
cord-356188-rwf78stz	280	17	on	on	IN
cord-356188-rwf78stz	280	18	the	the	DT
cord-356188-rwf78stz	280	19	surface	surface	NN
cord-356188-rwf78stz	280	20	of	of	IN
cord-356188-rwf78stz	280	21	phagocytic	phagocytic	JJ
cord-356188-rwf78stz	280	22	cells	cell	NNS
cord-356188-rwf78stz	280	23	.	.	.
cord-356188-rwf78stz	281	1	The	the	DT
cord-356188-rwf78stz	281	2	protein	protein	NN
cord-356188-rwf78stz	281	3	encoded	encode	VBN
cord-356188-rwf78stz	281	4	by	by	IN
cord-356188-rwf78stz	281	5	C1QBP	C1QBP	NNP
cord-356188-rwf78stz	281	6	is	be	VBZ
cord-356188-rwf78stz	281	7	a	a	DT
cord-356188-rwf78stz	281	8	critical	critical	JJ
cord-356188-rwf78stz	281	9	factor	factor	NN
cord-356188-rwf78stz	281	10	involved	involve	VBN
cord-356188-rwf78stz	281	11	in	in	IN
cord-356188-rwf78stz	281	12	complement	complement	JJ
cord-356188-rwf78stz	281	13	activation	activation	NN
cord-356188-rwf78stz	281	14	.	.	.
cord-356188-rwf78stz	282	1	Notably	notably	RB
cord-356188-rwf78stz	282	2	,	,	,
cord-356188-rwf78stz	282	3	presence	presence	NN
cord-356188-rwf78stz	282	4	of	of	IN
cord-356188-rwf78stz	282	5	low	low	JJ
cord-356188-rwf78stz	282	6	-	-	HYPH
cord-356188-rwf78stz	282	7	avidity	avidity	NN
cord-356188-rwf78stz	282	8	antibodies	antibody	NNS
cord-356188-rwf78stz	282	9	and	and	CC
cord-356188-rwf78stz	282	10	subsequent	subsequent	JJ
cord-356188-rwf78stz	282	11	formation	formation	NN
cord-356188-rwf78stz	282	12	of	of	IN
cord-356188-rwf78stz	282	13	immune	immune	JJ
cord-356188-rwf78stz	282	14	complex	complex	NN
cord-356188-rwf78stz	282	15	-	-	HYPH
cord-356188-rwf78stz	282	16	mediated	mediate	VBN
cord-356188-rwf78stz	282	17	complement	complement	NN
cord-356188-rwf78stz	282	18	activation	activation	NN
cord-356188-rwf78stz	282	19	in	in	IN
cord-356188-rwf78stz	282	20	the	the	DT
cord-356188-rwf78stz	282	21	lungs	lung	NNS
cord-356188-rwf78stz	282	22	of	of	IN
cord-356188-rwf78stz	282	23	patients	patient	NNS
cord-356188-rwf78stz	282	24	with	with	IN
cord-356188-rwf78stz	282	25	severe	severe	JJ
cord-356188-rwf78stz	282	26	influenza	influenza	NN
cord-356188-rwf78stz	282	27	infection	infection	NN
cord-356188-rwf78stz	282	28	are	be	VBP
cord-356188-rwf78stz	282	29	associated	associate	VBN
cord-356188-rwf78stz	282	30	with	with	IN
cord-356188-rwf78stz	282	31	severe	severe	JJ
cord-356188-rwf78stz	282	32	disease	disease	NN
cord-356188-rwf78stz	282	33	following	follow	VBG
cord-356188-rwf78stz	282	34	influenza	influenza	NN
cord-356188-rwf78stz	282	35	infection	infection	NN
cord-356188-rwf78stz	282	36	[	[	-LRB-
cord-356188-rwf78stz	282	37	107	107	CD
cord-356188-rwf78stz	282	38	]	]	-RRB-
cord-356188-rwf78stz	282	39	.	.	.
cord-356188-rwf78stz	283	1	Recently	recently	RB
cord-356188-rwf78stz	283	2	,	,	,
cord-356188-rwf78stz	283	3	"	"	``
cord-356188-rwf78stz	283	4	systems	system	NNS
cord-356188-rwf78stz	283	5	biology	biology	NN
cord-356188-rwf78stz	283	6	"	"	''
cord-356188-rwf78stz	283	7	strategies	strategy	NNS
cord-356188-rwf78stz	283	8	have	have	VBP
cord-356188-rwf78stz	283	9	emerged	emerge	VBN
cord-356188-rwf78stz	283	10	to	to	TO
cord-356188-rwf78stz	283	11	improve	improve	VB
cord-356188-rwf78stz	283	12	vaccine	vaccine	NN
cord-356188-rwf78stz	283	13	efficacy	efficacy	NN
cord-356188-rwf78stz	283	14	,	,	,
cord-356188-rwf78stz	283	15	measuring	measure	VBG
cord-356188-rwf78stz	283	16	expression	expression	NN
cord-356188-rwf78stz	283	17	patterns	pattern	NNS
cord-356188-rwf78stz	283	18	to	to	TO
cord-356188-rwf78stz	283	19	expose	expose	VB
cord-356188-rwf78stz	283	20	protective	protective	JJ
cord-356188-rwf78stz	283	21	molecular	molecular	JJ
cord-356188-rwf78stz	283	22	signatures	signature	NNS
cord-356188-rwf78stz	283	23	following	follow	VBG
cord-356188-rwf78stz	283	24	immunization	immunization	NN
cord-356188-rwf78stz	283	25	or	or	CC
cord-356188-rwf78stz	283	26	natural	natural	JJ
cord-356188-rwf78stz	283	27	infection	infection	NN
cord-356188-rwf78stz	283	28	[	[	-LRB-
cord-356188-rwf78stz	283	29	46	46	CD
cord-356188-rwf78stz	283	30	,	,	,
cord-356188-rwf78stz	283	31	205	205	CD
cord-356188-rwf78stz	283	32	]	]	-RRB-
cord-356188-rwf78stz	283	33	.	.	.
cord-356188-rwf78stz	284	1	Confirming	confirm	VBG
cord-356188-rwf78stz	284	2	in	in	IN
cord-356188-rwf78stz	284	3	vitro	vitro	FW
cord-356188-rwf78stz	284	4	mouse	mouse	NN
cord-356188-rwf78stz	284	5	studies	study	NNS
cord-356188-rwf78stz	284	6	,	,	,
cord-356188-rwf78stz	284	7	which	which	WDT
cord-356188-rwf78stz	284	8	suggest	suggest	VBP
cord-356188-rwf78stz	284	9	that	that	IN
cord-356188-rwf78stz	284	10	MBL	MBL	NNP
cord-356188-rwf78stz	284	11	can	can	MD
cord-356188-rwf78stz	284	12	neutralize	neutralize	VB
cord-356188-rwf78stz	284	13	influenza	influenza	NN
cord-356188-rwf78stz	284	14	[	[	-LRB-
cord-356188-rwf78stz	284	15	206	206	CD
cord-356188-rwf78stz	284	16	,	,	,
cord-356188-rwf78stz	284	17	207	207	CD
cord-356188-rwf78stz	284	18	]	]	-RRB-
cord-356188-rwf78stz	284	19	,	,	,
cord-356188-rwf78stz	284	20	human	human	JJ
cord-356188-rwf78stz	284	21	polymorphisms	polymorphism	NNS
cord-356188-rwf78stz	284	22	identified	identify	VBN
cord-356188-rwf78stz	284	23	within	within	IN
cord-356188-rwf78stz	284	24	MBL2	MBL2	NNP
cord-356188-rwf78stz	284	25	are	be	VBP
cord-356188-rwf78stz	284	26	associated	associate	VBN
cord-356188-rwf78stz	284	27	with	with	IN
cord-356188-rwf78stz	284	28	poor	poor	JJ
cord-356188-rwf78stz	284	29	antibody	antibody	NN
cord-356188-rwf78stz	284	30	responses	response	NNS
cord-356188-rwf78stz	284	31	to	to	IN
cord-356188-rwf78stz	284	32	influenza	influenza	NN
cord-356188-rwf78stz	284	33	vaccination	vaccination	NN
cord-356188-rwf78stz	284	34	[	[	-LRB-
cord-356188-rwf78stz	284	35	119	119	CD
cord-356188-rwf78stz	284	36	]	]	-RRB-
cord-356188-rwf78stz	284	37	.	.	.
cord-356188-rwf78stz	285	1	Although	although	IN
cord-356188-rwf78stz	285	2	MBL	MBL	NNP
cord-356188-rwf78stz	285	3	deficiency	deficiency	NN
cord-356188-rwf78stz	285	4	has	have	VBZ
cord-356188-rwf78stz	285	5	been	be	VBN
cord-356188-rwf78stz	285	6	observed	observe	VBN
cord-356188-rwf78stz	285	7	to	to	TO
cord-356188-rwf78stz	285	8	influence	influence	VB
cord-356188-rwf78stz	285	9	the	the	DT
cord-356188-rwf78stz	285	10	outcome	outcome	NN
cord-356188-rwf78stz	285	11	in	in	IN
cord-356188-rwf78stz	285	12	several	several	JJ
cord-356188-rwf78stz	285	13	respiratory	respiratory	JJ
cord-356188-rwf78stz	285	14	diseases	disease	NNS
cord-356188-rwf78stz	285	15	,	,	,
cord-356188-rwf78stz	285	16	including	include	VBG
cord-356188-rwf78stz	285	17	pneumococcus	pneumococcus	NN
cord-356188-rwf78stz	285	18	infection	infection	NN
cord-356188-rwf78stz	285	19	,	,	,
cord-356188-rwf78stz	285	20	tuberculosis	tuberculosis	NN
cord-356188-rwf78stz	285	21	,	,	,
cord-356188-rwf78stz	285	22	and	and	CC
cord-356188-rwf78stz	285	23	SARS	SARS	NNP
cord-356188-rwf78stz	285	24	CoV	CoV	NNP
cord-356188-rwf78stz	285	25	(	(	-LRB-
cord-356188-rwf78stz	285	26	reviewed	review	VBN
cord-356188-rwf78stz	285	27	in	in	IN
cord-356188-rwf78stz	285	28	ref	ref	NN
cord-356188-rwf78stz	285	29	.	.	.
cord-356188-rwf78stz	286	1	[	[	-LRB-
cord-356188-rwf78stz	286	2	208	208	CD
cord-356188-rwf78stz	286	3	]	]	-RRB-
cord-356188-rwf78stz	286	4	)	)	-RRB-
cord-356188-rwf78stz	286	5	,	,	,
cord-356188-rwf78stz	286	6	it	-PRON-	PRP
cord-356188-rwf78stz	286	7	did	do	VBD
cord-356188-rwf78stz	286	8	not	not	RB
cord-356188-rwf78stz	286	9	have	have	VB
cord-356188-rwf78stz	286	10	an	an	DT
cord-356188-rwf78stz	286	11	obvious	obvious	JJ
cord-356188-rwf78stz	286	12	role	role	NN
cord-356188-rwf78stz	286	13	in	in	IN
cord-356188-rwf78stz	286	14	A(H1N1)pdm09	A(H1N1)pdm09	NNP
cord-356188-rwf78stz	286	15	infection	infection	NN
cord-356188-rwf78stz	286	16	of	of	IN
cord-356188-rwf78stz	286	17	naïve	naïve	JJ
cord-356188-rwf78stz	286	18	individuals	individual	NNS
cord-356188-rwf78stz	286	19	[	[	-LRB-
cord-356188-rwf78stz	286	20	209	209	CD
cord-356188-rwf78stz	286	21	]	]	-RRB-
cord-356188-rwf78stz	286	22	.	.	.
cord-356188-rwf78stz	287	1	These	these	DT
cord-356188-rwf78stz	287	2	studies	study	NNS
cord-356188-rwf78stz	287	3	highlight	highlight	VBP
cord-356188-rwf78stz	287	4	the	the	DT
cord-356188-rwf78stz	287	5	involvement	involvement	NN
cord-356188-rwf78stz	287	6	of	of	IN
cord-356188-rwf78stz	287	7	host	host	NN
cord-356188-rwf78stz	287	8	ge	ge	NNP
cord-356188-rwf78stz	287	9	-	-	HYPH
cord-356188-rwf78stz	287	10	netics	netics	NNP
cord-356188-rwf78stz	287	11	in	in	IN
cord-356188-rwf78stz	287	12	development	development	NN
cord-356188-rwf78stz	287	13	of	of	IN
cord-356188-rwf78stz	287	14	enhanced	enhanced	JJ
cord-356188-rwf78stz	287	15	disease	disease	NN
cord-356188-rwf78stz	287	16	,	,	,
cord-356188-rwf78stz	287	17	although	although	IN
cord-356188-rwf78stz	287	18	they	-PRON-	PRP
cord-356188-rwf78stz	287	19	likely	likely	RB
cord-356188-rwf78stz	287	20	represent	represent	VBP
cord-356188-rwf78stz	287	21	a	a	DT
cord-356188-rwf78stz	287	22	small	small	JJ
cord-356188-rwf78stz	287	23	fraction	fraction	NN
cord-356188-rwf78stz	287	24	of	of	IN
cord-356188-rwf78stz	287	25	the	the	DT
cord-356188-rwf78stz	287	26	potential	potential	JJ
cord-356188-rwf78stz	287	27	regulatory	regulatory	JJ
cord-356188-rwf78stz	287	28	host	host	NN
cord-356188-rwf78stz	287	29	genetic	genetic	JJ
cord-356188-rwf78stz	287	30	elements	element	NNS
cord-356188-rwf78stz	287	31	.	.	.
cord-356188-rwf78stz	288	1	Studies	study	NNS
cord-356188-rwf78stz	288	2	of	of	IN
cord-356188-rwf78stz	288	3	innate	innate	JJ
cord-356188-rwf78stz	288	4	and	and	CC
cord-356188-rwf78stz	288	5	adaptive	adaptive	JJ
cord-356188-rwf78stz	288	6	immune	immune	JJ
cord-356188-rwf78stz	288	7	responses	response	NNS
cord-356188-rwf78stz	288	8	to	to	IN
cord-356188-rwf78stz	288	9	influenza	influenza	NN
cord-356188-rwf78stz	288	10	virus	virus	NN
cord-356188-rwf78stz	288	11	infection	infection	NN
cord-356188-rwf78stz	288	12	have	have	VBP
cord-356188-rwf78stz	288	13	been	be	VBN
cord-356188-rwf78stz	288	14	restricted	restrict	VBN
cord-356188-rwf78stz	288	15	primarily	primarily	RB
cord-356188-rwf78stz	288	16	to	to	IN
cord-356188-rwf78stz	288	17	animal	animal	NN
cord-356188-rwf78stz	288	18	models	model	NNS
cord-356188-rwf78stz	288	19	of	of	IN
cord-356188-rwf78stz	288	20	disease	disease	NN
cord-356188-rwf78stz	288	21	and	and	CC
cord-356188-rwf78stz	288	22	inflammation	inflammation	NN
cord-356188-rwf78stz	288	23	.	.	.
cord-356188-rwf78stz	289	1	As	as	IN
cord-356188-rwf78stz	289	2	our	-PRON-	PRP$
cord-356188-rwf78stz	289	3	immunological	immunological	JJ
cord-356188-rwf78stz	289	4	tools	tool	NNS
cord-356188-rwf78stz	289	5	become	become	VBP
cord-356188-rwf78stz	289	6	more	more	RBR
cord-356188-rwf78stz	289	7	sophisticated	sophisticated	JJ
cord-356188-rwf78stz	289	8	,	,	,
cord-356188-rwf78stz	289	9	more	more	JJR
cord-356188-rwf78stz	289	10	emphasis	emphasis	NN
cord-356188-rwf78stz	289	11	should	should	MD
cord-356188-rwf78stz	289	12	be	be	VB
cord-356188-rwf78stz	289	13	placed	place	VBN
cord-356188-rwf78stz	289	14	on	on	IN
cord-356188-rwf78stz	289	15	human	human	JJ
cord-356188-rwf78stz	289	16	immunology	immunology	NN
cord-356188-rwf78stz	289	17	as	as	IN
cord-356188-rwf78stz	289	18	opposed	oppose	VBN
cord-356188-rwf78stz	289	19	to	to	IN
cord-356188-rwf78stz	289	20	relying	rely	VBG
cord-356188-rwf78stz	289	21	solely	solely	RB
cord-356188-rwf78stz	289	22	on	on	IN
cord-356188-rwf78stz	289	23	animal	animal	NN
cord-356188-rwf78stz	289	24	infection	infection	NN
cord-356188-rwf78stz	289	25	models	model	NNS
cord-356188-rwf78stz	289	26	.	.	.
cord-356188-rwf78stz	290	1	Moreover	moreover	RB
cord-356188-rwf78stz	290	2	,	,	,
cord-356188-rwf78stz	290	3	the	the	DT
cord-356188-rwf78stz	290	4	vast	vast	JJ
cord-356188-rwf78stz	290	5	majority	majority	NN
cord-356188-rwf78stz	290	6	of	of	IN
cord-356188-rwf78stz	290	7	experimental	experimental	JJ
cord-356188-rwf78stz	290	8	data	datum	NNS
cord-356188-rwf78stz	290	9	in	in	IN
cord-356188-rwf78stz	290	10	humans	human	NNS
cord-356188-rwf78stz	290	11	is	be	VBZ
cord-356188-rwf78stz	290	12	restricted	restrict	VBN
cord-356188-rwf78stz	290	13	to	to	IN
cord-356188-rwf78stz	290	14	blood	blood	NN
cord-356188-rwf78stz	290	15	leukocytes	leukocyte	NNS
cord-356188-rwf78stz	290	16	,	,	,
cord-356188-rwf78stz	290	17	with	with	IN
cord-356188-rwf78stz	290	18	minimal	minimal	JJ
cord-356188-rwf78stz	290	19	emphasis	emphasis	NN
cord-356188-rwf78stz	290	20	placed	place	VBN
cord-356188-rwf78stz	290	21	on	on	IN
cord-356188-rwf78stz	290	22	the	the	DT
cord-356188-rwf78stz	290	23	innate	innate	JJ
cord-356188-rwf78stz	290	24	immune	immune	JJ
cord-356188-rwf78stz	290	25	response	response	NN
cord-356188-rwf78stz	290	26	,	,	,
cord-356188-rwf78stz	290	27	particularly	particularly	RB
cord-356188-rwf78stz	290	28	at	at	IN
cord-356188-rwf78stz	290	29	sites	site	NNS
cord-356188-rwf78stz	290	30	of	of	IN
cord-356188-rwf78stz	290	31	infection	infection	NN
cord-356188-rwf78stz	290	32	.	.	.
cord-356188-rwf78stz	291	1	As	as	IN
cord-356188-rwf78stz	291	2	a	a	DT
cord-356188-rwf78stz	291	3	result	result	NN
cord-356188-rwf78stz	291	4	,	,	,
cord-356188-rwf78stz	291	5	there	there	EX
cord-356188-rwf78stz	291	6	is	be	VBZ
cord-356188-rwf78stz	291	7	limited	limited	JJ
cord-356188-rwf78stz	291	8	scientific	scientific	JJ
cord-356188-rwf78stz	291	9	knowledge	knowledge	NN
cord-356188-rwf78stz	291	10	regarding	regard	VBG
cord-356188-rwf78stz	291	11	the	the	DT
cord-356188-rwf78stz	291	12	specific	specific	JJ
cord-356188-rwf78stz	291	13	roles	role	NNS
cord-356188-rwf78stz	291	14	of	of	IN
cord-356188-rwf78stz	291	15	immune	immune	JJ
cord-356188-rwf78stz	291	16	cells	cell	NNS
cord-356188-rwf78stz	291	17	in	in	IN
cord-356188-rwf78stz	291	18	affected	affected	JJ
cord-356188-rwf78stz	291	19	tissues	tissue	NNS
cord-356188-rwf78stz	291	20	.	.	.
cord-356188-rwf78stz	292	1	Understanding	understand	VBG
cord-356188-rwf78stz	292	2	the	the	DT
cord-356188-rwf78stz	292	3	innate	innate	JJ
cord-356188-rwf78stz	292	4	response	response	NN
cord-356188-rwf78stz	292	5	in	in	IN
cord-356188-rwf78stz	292	6	particular	particular	JJ
cord-356188-rwf78stz	292	7	is	be	VBZ
cord-356188-rwf78stz	292	8	critical	critical	JJ
cord-356188-rwf78stz	292	9	to	to	TO
cord-356188-rwf78stz	292	10	appreciate	appreciate	VB
cord-356188-rwf78stz	292	11	early	early	JJ
cord-356188-rwf78stz	292	12	determinants	determinant	NNS
cord-356188-rwf78stz	292	13	of	of	IN
cord-356188-rwf78stz	292	14	pathogenicity	pathogenicity	NN
cord-356188-rwf78stz	292	15	and	and	CC
cord-356188-rwf78stz	292	16	disease	disease	NN
cord-356188-rwf78stz	292	17	outcome	outcome	NN
cord-356188-rwf78stz	292	18	during	during	IN
cord-356188-rwf78stz	292	19	influenza	influenza	JJ
cord-356188-rwf78stz	292	20	infection	infection	NN
cord-356188-rwf78stz	292	21	.	.	.
cord-356188-rwf78stz	293	1	Influenza	Influenza	NNP
cord-356188-rwf78stz	293	2	Prevention	Prevention	NNP
cord-356188-rwf78stz	293	3	and	and	CC
cord-356188-rwf78stz	293	4	Control	Control	NNP
cord-356188-rwf78stz	293	5	Recommendations	Recommendations	NNPS
cord-356188-rwf78stz	293	6	:	:	:
cord-356188-rwf78stz	293	7	Recommendations	recommendation	NNS
cord-356188-rwf78stz	293	8	of	of	IN
cord-356188-rwf78stz	293	9	the	the	DT
cord-356188-rwf78stz	293	10	Advisory	Advisory	NNP
cord-356188-rwf78stz	293	11	Committee	Committee	NNP
cord-356188-rwf78stz	293	12	on	on	IN
cord-356188-rwf78stz	293	13	Immunization	Immunization	NNP
cord-356188-rwf78stz	293	14	Practices	Practices	NNPS
cord-356188-rwf78stz	293	15	(	(	-LRB-
cord-356188-rwf78stz	293	16	ACIP	ACIP	NNP
cord-356188-rwf78stz	293	17	)	)	-RRB-
cord-356188-rwf78stz	293	18	.	.	.
cord-356188-rwf78stz	294	1	CDC	CDC	NNP
cord-356188-rwf78stz	294	2	Influenza	Influenza	NNP
cord-356188-rwf78stz	294	3	A	A	NNP
cord-356188-rwf78stz	294	4	and	and	CC
cord-356188-rwf78stz	294	5	B	b	NN
cord-356188-rwf78stz	294	6	virus	virus	NN
cord-356188-rwf78stz	294	7	infections	infection	NNS
cord-356188-rwf78stz	294	8	in	in	IN
cord-356188-rwf78stz	294	9	children	child	NNS
cord-356188-rwf78stz	294	10	Burden	Burden	NNP
cord-356188-rwf78stz	294	11	of	of	IN
cord-356188-rwf78stz	294	12	influenza	influenza	NN
cord-356188-rwf78stz	294	13	in	in	IN
cord-356188-rwf78stz	294	14	children	child	NNS
cord-356188-rwf78stz	294	15	in	in	IN
cord-356188-rwf78stz	294	16	the	the	DT
cord-356188-rwf78stz	294	17	community	community	NN
cord-356188-rwf78stz	295	1	The	the	DT
cord-356188-rwf78stz	295	2	underrecognized	underrecognized	JJ
cord-356188-rwf78stz	295	3	burden	burden	NN
cord-356188-rwf78stz	295	4	of	of	IN
cord-356188-rwf78stz	295	5	influenza	influenza	NN
cord-356188-rwf78stz	295	6	in	in	IN
cord-356188-rwf78stz	295	7	young	young	JJ
cord-356188-rwf78stz	295	8	children	child	NNS
cord-356188-rwf78stz	296	1	The	the	DT
cord-356188-rwf78stz	296	2	effect	effect	NN
cord-356188-rwf78stz	296	3	of	of	IN
cord-356188-rwf78stz	296	4	influenza	influenza	NN
cord-356188-rwf78stz	296	5	on	on	IN
cord-356188-rwf78stz	296	6	hospitalizations	hospitalization	NNS
cord-356188-rwf78stz	296	7	,	,	,
cord-356188-rwf78stz	296	8	outpatient	outpatient	NN
cord-356188-rwf78stz	296	9	visits	visit	NNS
cord-356188-rwf78stz	296	10	,	,	,
cord-356188-rwf78stz	296	11	and	and	CC
cord-356188-rwf78stz	296	12	courses	course	NNS
cord-356188-rwf78stz	296	13	of	of	IN
cord-356188-rwf78stz	296	14	antibiotics	antibiotic	NNS
cord-356188-rwf78stz	296	15	in	in	IN
cord-356188-rwf78stz	296	16	children	child	NNS
cord-356188-rwf78stz	296	17	Children	child	NNS
cord-356188-rwf78stz	296	18	hospitalized	hospitalize	VBN
cord-356188-rwf78stz	296	19	with	with	IN
cord-356188-rwf78stz	296	20	2009	2009	CD
cord-356188-rwf78stz	296	21	novel	novel	NN
cord-356188-rwf78stz	296	22	influenza	influenza	NN
cord-356188-rwf78stz	296	23	A(H1N1	A(H1N1	NNP
cord-356188-rwf78stz	296	24	)	)	-RRB-
cord-356188-rwf78stz	296	25	in	in	IN
cord-356188-rwf78stz	296	26	California	California	NNP
cord-356188-rwf78stz	296	27	Age	Age	NNP
cord-356188-rwf78stz	296	28	-	-	HYPH
cord-356188-rwf78stz	296	29	specific	specific	JJ
cord-356188-rwf78stz	296	30	differences	difference	NNS
cord-356188-rwf78stz	296	31	in	in	IN
cord-356188-rwf78stz	296	32	influenza	influenza	NN
cord-356188-rwf78stz	296	33	A	a	DT
cord-356188-rwf78stz	296	34	epidemic	epidemic	NN
cord-356188-rwf78stz	296	35	curves	curve	NNS
cord-356188-rwf78stz	296	36	:	:	:
cord-356188-rwf78stz	296	37	do	do	VB
cord-356188-rwf78stz	296	38	children	child	NNS
cord-356188-rwf78stz	296	39	drive	drive	VB
cord-356188-rwf78stz	296	40	the	the	DT
cord-356188-rwf78stz	296	41	spread	spread	NN
cord-356188-rwf78stz	296	42	of	of	IN
cord-356188-rwf78stz	296	43	influenza	influenza	NN
cord-356188-rwf78stz	296	44	epidemics	epidemic	NNS
cord-356188-rwf78stz	296	45	?	?	.
cord-356188-rwf78stz	297	1	Estimating	estimate	VBG
cord-356188-rwf78stz	297	2	household	household	NN
cord-356188-rwf78stz	297	3	and	and	CC
cord-356188-rwf78stz	297	4	community	community	NN
cord-356188-rwf78stz	297	5	transmission	transmission	NN
cord-356188-rwf78stz	297	6	parameters	parameter	NNS
cord-356188-rwf78stz	297	7	for	for	IN
cord-356188-rwf78stz	297	8	influenza	influenza	JJ
cord-356188-rwf78stz	297	9	Risk	risk	NN
cord-356188-rwf78stz	297	10	factors	factor	NNS
cord-356188-rwf78stz	297	11	of	of	IN
cord-356188-rwf78stz	297	12	influenza	influenza	NN
cord-356188-rwf78stz	297	13	transmission	transmission	NN
cord-356188-rwf78stz	297	14	in	in	IN
cord-356188-rwf78stz	297	15	households	household	NNS
cord-356188-rwf78stz	298	1	Burden	Burden	NNP
cord-356188-rwf78stz	298	2	of	of	IN
cord-356188-rwf78stz	298	3	interpandemic	interpandemic	JJ
cord-356188-rwf78stz	298	4	influenza	influenza	NN
cord-356188-rwf78stz	298	5	in	in	IN
cord-356188-rwf78stz	298	6	children	child	NNS
cord-356188-rwf78stz	298	7	younger	young	JJR
cord-356188-rwf78stz	298	8	than	than	IN
cord-356188-rwf78stz	298	9	5	5	CD
cord-356188-rwf78stz	298	10	years	year	NNS
cord-356188-rwf78stz	298	11	:	:	:
cord-356188-rwf78stz	298	12	a	a	DT
cord-356188-rwf78stz	298	13	25-year	25-year	JJ
cord-356188-rwf78stz	298	14	prospective	prospective	JJ
cord-356188-rwf78stz	298	15	study	study	NN
cord-356188-rwf78stz	298	16	Wheezing	Wheezing	NNP
cord-356188-rwf78stz	298	17	,	,	,
cord-356188-rwf78stz	298	18	asthma	asthma	NN
cord-356188-rwf78stz	298	19	,	,	,
cord-356188-rwf78stz	298	20	and	and	CC
cord-356188-rwf78stz	298	21	pulmonary	pulmonary	JJ
cord-356188-rwf78stz	298	22	dysfunction	dysfunction	NN
cord-356188-rwf78stz	298	23	10	10	CD
cord-356188-rwf78stz	298	24	years	year	NNS
cord-356188-rwf78stz	298	25	after	after	IN
cord-356188-rwf78stz	298	26	infection	infection	NN
cord-356188-rwf78stz	298	27	with	with	IN
cord-356188-rwf78stz	298	28	respiratory	respiratory	JJ
cord-356188-rwf78stz	298	29	syncytial	syncytial	JJ
cord-356188-rwf78stz	298	30	virus	virus	NN
cord-356188-rwf78stz	298	31	in	in	IN
cord-356188-rwf78stz	298	32	infancy	infancy	NN
cord-356188-rwf78stz	299	1	Respiratory	respiratory	JJ
cord-356188-rwf78stz	299	2	syncytial	syncytial	JJ
cord-356188-rwf78stz	299	3	virus	virus	NN
cord-356188-rwf78stz	299	4	bronchiolitis	bronchiolitis	NN
cord-356188-rwf78stz	299	5	in	in	IN
cord-356188-rwf78stz	299	6	infancy	infancy	NN
cord-356188-rwf78stz	299	7	is	be	VBZ
cord-356188-rwf78stz	299	8	an	an	DT
cord-356188-rwf78stz	299	9	important	important	JJ
cord-356188-rwf78stz	299	10	risk	risk	NN
cord-356188-rwf78stz	299	11	factor	factor	NN
cord-356188-rwf78stz	299	12	for	for	IN
cord-356188-rwf78stz	299	13	asthma	asthma	NN
cord-356188-rwf78stz	299	14	and	and	CC
cord-356188-rwf78stz	299	15	allergy	allergy	NN
cord-356188-rwf78stz	299	16	at	at	IN
cord-356188-rwf78stz	299	17	age	age	NN
cord-356188-rwf78stz	299	18	7	7	CD
cord-356188-rwf78stz	299	19	Severe	severe	JJ
cord-356188-rwf78stz	299	20	respiratory	respiratory	JJ
cord-356188-rwf78stz	299	21	syncytial	syncytial	JJ
cord-356188-rwf78stz	299	22	virus	virus	NN
cord-356188-rwf78stz	299	23	bronchiolitis	bronchiolitis	NN
cord-356188-rwf78stz	299	24	in	in	IN
cord-356188-rwf78stz	299	25	infancy	infancy	NN
cord-356188-rwf78stz	299	26	and	and	CC
cord-356188-rwf78stz	299	27	asthma	asthma	NN
cord-356188-rwf78stz	299	28	and	and	CC
cord-356188-rwf78stz	299	29	allergy	allergy	NN
cord-356188-rwf78stz	299	30	at	at	IN
cord-356188-rwf78stz	299	31	age	age	NN
cord-356188-rwf78stz	299	32	13	13	CD
cord-356188-rwf78stz	299	33	Influenza	Influenza	NNP
cord-356188-rwf78stz	299	34	-	-	HYPH
cord-356188-rwf78stz	299	35	associated	associate	VBN
cord-356188-rwf78stz	299	36	hospitalizations	hospitalization	NNS
cord-356188-rwf78stz	299	37	in	in	IN
cord-356188-rwf78stz	299	38	the	the	DT
cord-356188-rwf78stz	299	39	United	United	NNP
cord-356188-rwf78stz	299	40	States	States	NNP
cord-356188-rwf78stz	299	41	Epidemiology	Epidemiology	NNP
cord-356188-rwf78stz	299	42	of	of	IN
cord-356188-rwf78stz	299	43	viral	viral	JJ
cord-356188-rwf78stz	299	44	respiratory	respiratory	JJ
cord-356188-rwf78stz	299	45	infections	infection	NNS
cord-356188-rwf78stz	299	46	Estimates	estimate	NNS
cord-356188-rwf78stz	299	47	of	of	IN
cord-356188-rwf78stz	299	48	deaths	death	NNS
cord-356188-rwf78stz	299	49	associated	associate	VBN
cord-356188-rwf78stz	299	50	with	with	IN
cord-356188-rwf78stz	299	51	seasonal	seasonal	JJ
cord-356188-rwf78stz	299	52	influenza	influenza	NN
cord-356188-rwf78stz	299	53	-	-	:
cord-356188-rwf78stz	299	54	United	United	NNP
cord-356188-rwf78stz	299	55	States	States	NNP
cord-356188-rwf78stz	299	56	Global	global	JJ
cord-356188-rwf78stz	299	57	burden	burden	NN
cord-356188-rwf78stz	299	58	of	of	IN
cord-356188-rwf78stz	299	59	respiratory	respiratory	JJ
cord-356188-rwf78stz	299	60	infections	infection	NNS
cord-356188-rwf78stz	299	61	due	due	JJ
cord-356188-rwf78stz	299	62	to	to	IN
cord-356188-rwf78stz	299	63	seasonal	seasonal	JJ
cord-356188-rwf78stz	299	64	influenza	influenza	NN
cord-356188-rwf78stz	299	65	in	in	IN
cord-356188-rwf78stz	299	66	young	young	JJ
cord-356188-rwf78stz	299	67	children	child	NNS
cord-356188-rwf78stz	299	68	:	:	:
cord-356188-rwf78stz	299	69	a	a	DT
cord-356188-rwf78stz	299	70	systematic	systematic	JJ
cord-356188-rwf78stz	299	71	review	review	NN
cord-356188-rwf78stz	299	72	and	and	CC
cord-356188-rwf78stz	299	73	metaanalysis	metaanalysis	NN
cord-356188-rwf78stz	300	1	The	the	DT
cord-356188-rwf78stz	300	2	annual	annual	JJ
cord-356188-rwf78stz	300	3	impact	impact	NN
cord-356188-rwf78stz	300	4	of	of	IN
cord-356188-rwf78stz	300	5	seasonal	seasonal	JJ
cord-356188-rwf78stz	300	6	influenza	influenza	NN
cord-356188-rwf78stz	300	7	in	in	IN
cord-356188-rwf78stz	300	8	the	the	DT
cord-356188-rwf78stz	300	9	US	US	NNP
cord-356188-rwf78stz	300	10	:	:	:
cord-356188-rwf78stz	300	11	measuring	measure	VBG
cord-356188-rwf78stz	300	12	disease	disease	NN
cord-356188-rwf78stz	300	13	burden	burden	NN
cord-356188-rwf78stz	300	14	and	and	CC
cord-356188-rwf78stz	300	15	costs	cost	VBZ
cord-356188-rwf78stz	300	16	High	high	JJ
cord-356188-rwf78stz	300	17	costs	cost	NNS
cord-356188-rwf78stz	300	18	of	of	IN
cord-356188-rwf78stz	300	19	influenza	influenza	NN
cord-356188-rwf78stz	300	20	:	:	:
cord-356188-rwf78stz	300	21	direct	direct	JJ
cord-356188-rwf78stz	300	22	medical	medical	JJ
cord-356188-rwf78stz	300	23	costs	cost	NNS
cord-356188-rwf78stz	300	24	of	of	IN
cord-356188-rwf78stz	300	25	influenza	influenza	NN
cord-356188-rwf78stz	300	26	disease	disease	NN
cord-356188-rwf78stz	300	27	in	in	IN
cord-356188-rwf78stz	300	28	young	young	JJ
cord-356188-rwf78stz	300	29	children	child	NNS
cord-356188-rwf78stz	300	30	Standardization	Standardization	NNP
cord-356188-rwf78stz	300	31	of	of	IN
cord-356188-rwf78stz	300	32	terminology	terminology	NN
cord-356188-rwf78stz	300	33	of	of	IN
cord-356188-rwf78stz	300	34	the	the	DT
cord-356188-rwf78stz	300	35	pandemic	pandemic	NN
cord-356188-rwf78stz	300	36	A(H1N1	A(H1N1	NNP
cord-356188-rwf78stz	300	37	)	)	-RRB-
cord-356188-rwf78stz	301	1	Severe	severe	JJ
cord-356188-rwf78stz	301	2	respiratory	respiratory	JJ
cord-356188-rwf78stz	301	3	disease	disease	NN
cord-356188-rwf78stz	301	4	concurrent	concurrent	JJ
cord-356188-rwf78stz	301	5	with	with	IN
cord-356188-rwf78stz	301	6	the	the	DT
cord-356188-rwf78stz	301	7	circulation	circulation	NN
cord-356188-rwf78stz	301	8	of	of	IN
cord-356188-rwf78stz	301	9	H1N1	H1N1	NNP
cord-356188-rwf78stz	301	10	influenza	influenza	NN
cord-356188-rwf78stz	301	11	Pneumonia	pneumonia	NN
cord-356188-rwf78stz	301	12	and	and	CC
cord-356188-rwf78stz	301	13	respiratory	respiratory	JJ
cord-356188-rwf78stz	301	14	failure	failure	NN
cord-356188-rwf78stz	301	15	from	from	IN
cord-356188-rwf78stz	301	16	swine	swine	NN
cord-356188-rwf78stz	301	17	-	-	HYPH
cord-356188-rwf78stz	301	18	origin	origin	NN
cord-356188-rwf78stz	301	19	influenza	influenza	NN
cord-356188-rwf78stz	301	20	A	A	NNP
cord-356188-rwf78stz	301	21	(	(	-LRB-
cord-356188-rwf78stz	301	22	H1N1	H1N1	NNP
cord-356188-rwf78stz	301	23	)	)	-RRB-
cord-356188-rwf78stz	301	24	in	in	IN
cord-356188-rwf78stz	301	25	Mexico	Mexico	NNP
cord-356188-rwf78stz	301	26	Cross	Cross	NNP
cord-356188-rwf78stz	301	27	-	-	JJ
cord-356188-rwf78stz	301	28	reactive	reactive	JJ
cord-356188-rwf78stz	301	29	antibody	antibody	NN
cord-356188-rwf78stz	301	30	responses	response	NNS
cord-356188-rwf78stz	301	31	to	to	IN
cord-356188-rwf78stz	301	32	the	the	DT
cord-356188-rwf78stz	301	33	2009	2009	CD
cord-356188-rwf78stz	301	34	pandemic	pandemic	NN
cord-356188-rwf78stz	301	35	H1N1	H1N1	NNP
cord-356188-rwf78stz	301	36	influenza	influenza	NN
cord-356188-rwf78stz	301	37	virus	virus	NN
cord-356188-rwf78stz	301	38	Risk	risk	NN
cord-356188-rwf78stz	301	39	factors	factor	NNS
cord-356188-rwf78stz	301	40	for	for	IN
cord-356188-rwf78stz	301	41	severe	severe	JJ
cord-356188-rwf78stz	301	42	outcomes	outcome	NNS
cord-356188-rwf78stz	301	43	follow	follow	VBP
cord-356188-rwf78stz	301	44	Novel	Novel	NNP
cord-356188-rwf78stz	301	45	influenza	influenza	NN
cord-356188-rwf78stz	301	46	A	a	NN
cord-356188-rwf78stz	301	47	(	(	-LRB-
cord-356188-rwf78stz	301	48	H1N1	H1N1	NNP
cord-356188-rwf78stz	301	49	)	)	-RRB-
cord-356188-rwf78stz	301	50	virus	virus	NN
cord-356188-rwf78stz	301	51	infections	infection	NNS
cord-356188-rwf78stz	301	52	in	in	IN
cord-356188-rwf78stz	301	53	three	three	CD
cord-356188-rwf78stz	301	54	pregnant	pregnant	JJ
cord-356188-rwf78stz	301	55	women	woman	NNS
cord-356188-rwf78stz	301	56	-	-	HYPH
cord-356188-rwf78stz	301	57	United	United	NNP
cord-356188-rwf78stz	301	58	States	States	NNP
cord-356188-rwf78stz	301	59	Severe	Severe	NNP
cord-356188-rwf78stz	301	60	2009	2009	CD
cord-356188-rwf78stz	301	61	H1N1	H1N1	NNP
cord-356188-rwf78stz	301	62	influenza	influenza	NN
cord-356188-rwf78stz	301	63	in	in	IN
cord-356188-rwf78stz	301	64	pregnant	pregnant	JJ
cord-356188-rwf78stz	301	65	and	and	CC
cord-356188-rwf78stz	301	66	postpartum	postpartum	NN
cord-356188-rwf78stz	301	67	women	woman	NNS
cord-356188-rwf78stz	301	68	in	in	IN
cord-356188-rwf78stz	301	69	California	California	NNP
cord-356188-rwf78stz	301	70	Correlates	Correlates	NNPS
cord-356188-rwf78stz	301	71	of	of	IN
cord-356188-rwf78stz	301	72	severe	severe	JJ
cord-356188-rwf78stz	301	73	disease	disease	NN
cord-356188-rwf78stz	301	74	in	in	IN
cord-356188-rwf78stz	301	75	patients	patient	NNS
cord-356188-rwf78stz	301	76	with	with	IN
cord-356188-rwf78stz	301	77	2009	2009	CD
cord-356188-rwf78stz	301	78	pandemic	pandemic	NN
cord-356188-rwf78stz	301	79	influenza	influenza	NN
cord-356188-rwf78stz	301	80	(	(	-LRB-
cord-356188-rwf78stz	301	81	H1N1	H1N1	NNP
cord-356188-rwf78stz	301	82	)	)	-RRB-
cord-356188-rwf78stz	301	83	virus	virus	NN
cord-356188-rwf78stz	301	84	infection	infection	NN
cord-356188-rwf78stz	301	85	Insights	insight	NNS
cord-356188-rwf78stz	301	86	into	into	IN
cord-356188-rwf78stz	301	87	the	the	DT
cord-356188-rwf78stz	301	88	interaction	interaction	NN
cord-356188-rwf78stz	301	89	between	between	IN
cord-356188-rwf78stz	301	90	influenza	influenza	NN
cord-356188-rwf78stz	301	91	virus	virus	NN
cord-356188-rwf78stz	301	92	and	and	CC
cord-356188-rwf78stz	301	93	pneumococcus	pneumococcus	NNP
cord-356188-rwf78stz	301	94	Community	Community	NNP
cord-356188-rwf78stz	301	95	-	-	HYPH
cord-356188-rwf78stz	301	96	acquired	acquire	VBN
cord-356188-rwf78stz	301	97	pneumonia	pneumonia	NN
cord-356188-rwf78stz	301	98	due	due	IN
cord-356188-rwf78stz	301	99	to	to	IN
cord-356188-rwf78stz	301	100	pandemic	pandemic	NN
cord-356188-rwf78stz	301	101	A(H1N1)2009	a(h1n1)2009	CD
cord-356188-rwf78stz	301	102	influenzavirus	influenzavirus	NN
cord-356188-rwf78stz	301	103	and	and	CC
cord-356188-rwf78stz	301	104	methicillin	methicillin	NN
cord-356188-rwf78stz	301	105	resistant	resistant	JJ
cord-356188-rwf78stz	301	106	Staphylococcus	Staphylococcus	NNP
cord-356188-rwf78stz	301	107	aureus	aureus	NN
cord-356188-rwf78stz	301	108	co	co	NN
cord-356188-rwf78stz	301	109	-	-	NN
cord-356188-rwf78stz	301	110	infection	infection	JJ
cord-356188-rwf78stz	301	111	Bacterial	bacterial	JJ
cord-356188-rwf78stz	301	112	coinfections	coinfection	NNS
cord-356188-rwf78stz	301	113	in	in	IN
cord-356188-rwf78stz	301	114	lung	lung	NN
cord-356188-rwf78stz	301	115	tissue	tissue	NN
cord-356188-rwf78stz	301	116	specimens	specimen	NNS
cord-356188-rwf78stz	301	117	from	from	IN
cord-356188-rwf78stz	301	118	fatal	fatal	JJ
cord-356188-rwf78stz	301	119	cases	case	NNS
cord-356188-rwf78stz	301	120	of	of	IN
cord-356188-rwf78stz	301	121	2009	2009	CD
cord-356188-rwf78stz	301	122	pandemic	pandemic	NN
cord-356188-rwf78stz	301	123	influenza	influenza	NN
cord-356188-rwf78stz	301	124	A	A	NNP
cord-356188-rwf78stz	301	125	(	(	-LRB-
cord-356188-rwf78stz	301	126	H1N1)-United	H1N1)-United	NNP
cord-356188-rwf78stz	301	127	States	States	NNP
cord-356188-rwf78stz	301	128	Lung	Lung	NNP
cord-356188-rwf78stz	301	129	pathology	pathology	NN
cord-356188-rwf78stz	301	130	in	in	IN
cord-356188-rwf78stz	301	131	fatal	fatal	JJ
cord-356188-rwf78stz	301	132	novel	novel	JJ
cord-356188-rwf78stz	301	133	human	human	NN
cord-356188-rwf78stz	301	134	influenza	influenza	NN
cord-356188-rwf78stz	301	135	A	A	NNP
cord-356188-rwf78stz	301	136	(	(	-LRB-
cord-356188-rwf78stz	301	137	H1N1	H1N1	NNP
cord-356188-rwf78stz	301	138	)	)	-RRB-
cord-356188-rwf78stz	301	139	infection	infection	NN
cord-356188-rwf78stz	301	140	Cross	Cross	NNP
cord-356188-rwf78stz	301	141	-	-	NN
cord-356188-rwf78stz	301	142	recognition	recognition	NN
cord-356188-rwf78stz	301	143	of	of	IN
cord-356188-rwf78stz	301	144	avian	avian	JJ
cord-356188-rwf78stz	301	145	H5N1	H5N1	NNP
cord-356188-rwf78stz	301	146	influenza	influenza	NN
cord-356188-rwf78stz	301	147	virus	virus	NN
cord-356188-rwf78stz	301	148	by	by	IN
cord-356188-rwf78stz	301	149	human	human	JJ
cord-356188-rwf78stz	301	150	cytotoxic	cytotoxic	JJ
cord-356188-rwf78stz	301	151	T	t	NN
cord-356188-rwf78stz	301	152	-	-	HYPH
cord-356188-rwf78stz	301	153	lymphocyte	lymphocyte	NN
cord-356188-rwf78stz	301	154	populations	population	NNS
cord-356188-rwf78stz	301	155	directed	direct	VBN
cord-356188-rwf78stz	301	156	to	to	IN
cord-356188-rwf78stz	301	157	human	human	JJ
cord-356188-rwf78stz	301	158	influenza	influenza	NN
cord-356188-rwf78stz	301	159	A	a	DT
cord-356188-rwf78stz	301	160	virus	virus	NN
cord-356188-rwf78stz	301	161	Prevention	prevention	NN
cord-356188-rwf78stz	301	162	and	and	CC
cord-356188-rwf78stz	301	163	control	control	NN
cord-356188-rwf78stz	301	164	of	of	IN
cord-356188-rwf78stz	301	165	influenza	influenza	NN
cord-356188-rwf78stz	301	166	with	with	IN
cord-356188-rwf78stz	301	167	vaccines	vaccine	NNS
cord-356188-rwf78stz	301	168	:	:	:
cord-356188-rwf78stz	301	169	recommendations	recommendation	NNS
cord-356188-rwf78stz	301	170	of	of	IN
cord-356188-rwf78stz	301	171	the	the	DT
cord-356188-rwf78stz	301	172	Advisory	Advisory	NNP
cord-356188-rwf78stz	301	173	Committee	Committee	NNP
cord-356188-rwf78stz	301	174	on	on	IN
cord-356188-rwf78stz	301	175	Immunization	Immunization	NNP
cord-356188-rwf78stz	301	176	Practices	Practices	NNPS
cord-356188-rwf78stz	301	177	(	(	-LRB-
cord-356188-rwf78stz	301	178	ACIP	ACIP	NNP
cord-356188-rwf78stz	301	179	)	)	-RRB-
cord-356188-rwf78stz	301	180	Assessment	Assessment	NNP
cord-356188-rwf78stz	301	181	of	of	IN
cord-356188-rwf78stz	301	182	immunity	immunity	NN
cord-356188-rwf78stz	301	183	to	to	IN
cord-356188-rwf78stz	301	184	influenza	influenza	NN
cord-356188-rwf78stz	301	185	using	use	VBG
cord-356188-rwf78stz	301	186	artifical	artifical	JJ
cord-356188-rwf78stz	301	187	challenge	challenge	NN
cord-356188-rwf78stz	301	188	of	of	IN
cord-356188-rwf78stz	301	189	normal	normal	JJ
cord-356188-rwf78stz	301	190	volunteers	volunteer	NNS
cord-356188-rwf78stz	301	191	with	with	IN
cord-356188-rwf78stz	301	192	influenza	influenza	NN
cord-356188-rwf78stz	301	193	virus	virus	NN
cord-356188-rwf78stz	301	194	Serum	serum	NN
cord-356188-rwf78stz	301	195	and	and	CC
cord-356188-rwf78stz	301	196	nasal	nasal	NN
cord-356188-rwf78stz	301	197	wash	wash	NN
cord-356188-rwf78stz	301	198	antibodies	antibody	NNS
cord-356188-rwf78stz	301	199	associated	associate	VBN
cord-356188-rwf78stz	301	200	with	with	IN
cord-356188-rwf78stz	301	201	resistance	resistance	NN
cord-356188-rwf78stz	301	202	to	to	IN
cord-356188-rwf78stz	301	203	experimental	experimental	JJ
cord-356188-rwf78stz	301	204	challenge	challenge	NN
cord-356188-rwf78stz	301	205	with	with	IN
cord-356188-rwf78stz	301	206	influenza	influenza	NN
cord-356188-rwf78stz	301	207	A	a	DT
cord-356188-rwf78stz	301	208	wild	wild	JJ
cord-356188-rwf78stz	301	209	-	-	HYPH
cord-356188-rwf78stz	301	210	type	type	NN
cord-356188-rwf78stz	301	211	virus	virus	NN
cord-356188-rwf78stz	301	212	Safety	safety	NN
cord-356188-rwf78stz	301	213	of	of	IN
cord-356188-rwf78stz	301	214	high	high	JJ
cord-356188-rwf78stz	301	215	doses	dose	NNS
cord-356188-rwf78stz	301	216	of	of	IN
cord-356188-rwf78stz	301	217	influenza	influenza	NN
cord-356188-rwf78stz	301	218	vaccine	vaccine	NN
cord-356188-rwf78stz	301	219	and	and	CC
cord-356188-rwf78stz	301	220	effect	effect	NN
cord-356188-rwf78stz	301	221	on	on	IN
cord-356188-rwf78stz	301	222	antibody	antibody	NN
cord-356188-rwf78stz	301	223	responses	response	NNS
cord-356188-rwf78stz	301	224	in	in	IN
cord-356188-rwf78stz	301	225	elderly	elderly	JJ
cord-356188-rwf78stz	301	226	persons	person	NNS
cord-356188-rwf78stz	301	227	Safety	safety	NN
cord-356188-rwf78stz	301	228	and	and	CC
cord-356188-rwf78stz	301	229	immunogenicity	immunogenicity	NN
cord-356188-rwf78stz	301	230	of	of	IN
cord-356188-rwf78stz	301	231	a	a	DT
cord-356188-rwf78stz	301	232	high	high	JJ
cord-356188-rwf78stz	301	233	dosage	dosage	NN
cord-356188-rwf78stz	301	234	trivalent	trivalent	JJ
cord-356188-rwf78stz	301	235	influenza	influenza	NN
cord-356188-rwf78stz	301	236	vaccine	vaccine	NN
cord-356188-rwf78stz	301	237	among	among	IN
cord-356188-rwf78stz	301	238	elderly	elderly	JJ
cord-356188-rwf78stz	301	239	subjects	subject	NNS
cord-356188-rwf78stz	302	1	Parenteral	parenteral	JJ
cord-356188-rwf78stz	302	2	vaccination	vaccination	NN
cord-356188-rwf78stz	302	3	against	against	IN
cord-356188-rwf78stz	302	4	influenza	influenza	NN
cord-356188-rwf78stz	302	5	does	do	VBZ
cord-356188-rwf78stz	302	6	not	not	RB
cord-356188-rwf78stz	302	7	induce	induce	VB
cord-356188-rwf78stz	302	8	a	a	DT
cord-356188-rwf78stz	302	9	local	local	JJ
cord-356188-rwf78stz	302	10	antigen	antigen	NN
cord-356188-rwf78stz	302	11	-	-	HYPH
cord-356188-rwf78stz	302	12	specific	specific	JJ
cord-356188-rwf78stz	302	13	immune	immune	JJ
cord-356188-rwf78stz	302	14	response	response	NN
cord-356188-rwf78stz	302	15	in	in	IN
cord-356188-rwf78stz	302	16	the	the	DT
cord-356188-rwf78stz	302	17	nasal	nasal	NN
cord-356188-rwf78stz	302	18	mucosa	mucosa	JJ
cord-356188-rwf78stz	303	1	An	an	DT
cord-356188-rwf78stz	303	2	early	early	JJ
cord-356188-rwf78stz	303	3	humoral	humoral	JJ
cord-356188-rwf78stz	303	4	immune	immune	JJ
cord-356188-rwf78stz	303	5	response	response	NN
cord-356188-rwf78stz	303	6	in	in	IN
cord-356188-rwf78stz	303	7	peripheral	peripheral	JJ
cord-356188-rwf78stz	303	8	blood	blood	NN
cord-356188-rwf78stz	303	9	following	follow	VBG
cord-356188-rwf78stz	303	10	parenteral	parenteral	JJ
cord-356188-rwf78stz	303	11	inactivated	inactivate	VBN
cord-356188-rwf78stz	303	12	influenza	influenza	NN
cord-356188-rwf78stz	303	13	vaccination	vaccination	NN
cord-356188-rwf78stz	303	14	Systemic	systemic	JJ
cord-356188-rwf78stz	303	15	and	and	CC
cord-356188-rwf78stz	303	16	mucosal	mucosal	JJ
cord-356188-rwf78stz	303	17	immune	immune	JJ
cord-356188-rwf78stz	303	18	responses	response	NNS
cord-356188-rwf78stz	303	19	in	in	IN
cord-356188-rwf78stz	303	20	young	young	JJ
cord-356188-rwf78stz	303	21	children	child	NNS
cord-356188-rwf78stz	303	22	and	and	CC
cord-356188-rwf78stz	303	23	adults	adult	NNS
cord-356188-rwf78stz	303	24	after	after	IN
cord-356188-rwf78stz	303	25	parenteral	parenteral	JJ
cord-356188-rwf78stz	303	26	influenza	influenza	NN
cord-356188-rwf78stz	303	27	vaccination	vaccination	NN
cord-356188-rwf78stz	303	28	Comparison	comparison	NN
cord-356188-rwf78stz	303	29	of	of	IN
cord-356188-rwf78stz	303	30	the	the	DT
cord-356188-rwf78stz	303	31	influenza	influenza	NN
cord-356188-rwf78stz	303	32	virus	virus	NN
cord-356188-rwf78stz	303	33	-	-	HYPH
cord-356188-rwf78stz	303	34	specific	specific	JJ
cord-356188-rwf78stz	303	35	effector	effector	NN
cord-356188-rwf78stz	303	36	and	and	CC
cord-356188-rwf78stz	303	37	memory	memory	NN
cord-356188-rwf78stz	303	38	B	b	NN
cord-356188-rwf78stz	303	39	-	-	HYPH
cord-356188-rwf78stz	303	40	cell	cell	NN
cord-356188-rwf78stz	303	41	responses	response	NNS
cord-356188-rwf78stz	303	42	to	to	IN
cord-356188-rwf78stz	303	43	immunization	immunization	NN
cord-356188-rwf78stz	303	44	of	of	IN
cord-356188-rwf78stz	303	45	children	child	NNS
cord-356188-rwf78stz	303	46	and	and	CC
cord-356188-rwf78stz	303	47	adults	adult	NNS
cord-356188-rwf78stz	303	48	with	with	IN
cord-356188-rwf78stz	303	49	live	live	JJ
cord-356188-rwf78stz	303	50	attenuated	attenuated	JJ
cord-356188-rwf78stz	303	51	or	or	CC
cord-356188-rwf78stz	303	52	inactivated	inactivate	VBN
cord-356188-rwf78stz	303	53	influenza	influenza	NN
cord-356188-rwf78stz	303	54	virus	virus	NN
cord-356188-rwf78stz	303	55	vaccines	vaccine	NNS
cord-356188-rwf78stz	303	56	Correlates	correlate	VBZ
cord-356188-rwf78stz	303	57	of	of	IN
cord-356188-rwf78stz	303	58	immune	immune	JJ
cord-356188-rwf78stz	303	59	protection	protection	NN
cord-356188-rwf78stz	303	60	induced	induce	VBN
cord-356188-rwf78stz	303	61	by	by	IN
cord-356188-rwf78stz	303	62	live	live	JJ
cord-356188-rwf78stz	303	63	,	,	,
cord-356188-rwf78stz	303	64	attenuated	attenuated	JJ
cord-356188-rwf78stz	303	65	,	,	,
cord-356188-rwf78stz	303	66	cold	cold	JJ
cord-356188-rwf78stz	303	67	-	-	HYPH
cord-356188-rwf78stz	303	68	adapted	adapt	VBN
cord-356188-rwf78stz	303	69	,	,	,
cord-356188-rwf78stz	303	70	trivalent	trivalent	JJ
cord-356188-rwf78stz	304	1	,	,	,
cord-356188-rwf78stz	304	2	intranasal	intranasal	NNP
cord-356188-rwf78stz	304	3	influenza	influenza	NN
cord-356188-rwf78stz	304	4	virus	virus	NNP
cord-356188-rwf78stz	304	5	vaccine	vaccine	NN
cord-356188-rwf78stz	304	6	Live	live	VB
cord-356188-rwf78stz	304	7	attenuated	attenuated	JJ
cord-356188-rwf78stz	304	8	versus	versus	IN
cord-356188-rwf78stz	304	9	inactivated	inactivate	VBN
cord-356188-rwf78stz	304	10	influenza	influenza	NN
cord-356188-rwf78stz	304	11	vaccine	vaccine	NN
cord-356188-rwf78stz	304	12	in	in	IN
cord-356188-rwf78stz	304	13	infants	infant	NNS
cord-356188-rwf78stz	304	14	and	and	CC
cord-356188-rwf78stz	304	15	young	young	JJ
cord-356188-rwf78stz	304	16	children	child	NNS
cord-356188-rwf78stz	304	17	Systems	system	NNS
cord-356188-rwf78stz	304	18	biology	biology	NN
cord-356188-rwf78stz	304	19	of	of	IN
cord-356188-rwf78stz	304	20	vaccination	vaccination	NN
cord-356188-rwf78stz	304	21	for	for	IN
cord-356188-rwf78stz	304	22	seasonal	seasonal	JJ
cord-356188-rwf78stz	304	23	influenza	influenza	NN
cord-356188-rwf78stz	304	24	in	in	IN
cord-356188-rwf78stz	304	25	humans	human	NNS
cord-356188-rwf78stz	304	26	Development	Development	NNP
cord-356188-rwf78stz	304	27	and	and	CC
cord-356188-rwf78stz	304	28	persistence	persistence	NN
cord-356188-rwf78stz	304	29	of	of	IN
cord-356188-rwf78stz	304	30	local	local	JJ
cord-356188-rwf78stz	304	31	and	and	CC
cord-356188-rwf78stz	304	32	systemic	systemic	JJ
cord-356188-rwf78stz	304	33	antibody	antibody	NN
cord-356188-rwf78stz	304	34	responses	response	NNS
cord-356188-rwf78stz	304	35	in	in	IN
cord-356188-rwf78stz	304	36	adults	adult	NNS
cord-356188-rwf78stz	304	37	given	give	VBN
cord-356188-rwf78stz	304	38	live	live	VBP
cord-356188-rwf78stz	304	39	attenuated	attenuate	VBN
cord-356188-rwf78stz	304	40	or	or	CC
cord-356188-rwf78stz	304	41	inactivated	inactivate	VBN
cord-356188-rwf78stz	304	42	influenza	influenza	NN
cord-356188-rwf78stz	304	43	A	a	DT
cord-356188-rwf78stz	304	44	virus	virus	NN
cord-356188-rwf78stz	304	45	vaccine	vaccine	NN
cord-356188-rwf78stz	304	46	Inactivated	inactivate	VBN
cord-356188-rwf78stz	304	47	influenza	influenza	NN
cord-356188-rwf78stz	304	48	virus	virus	NN
cord-356188-rwf78stz	304	49	vaccines	vaccine	NNS
cord-356188-rwf78stz	304	50	in	in	IN
cord-356188-rwf78stz	304	51	children	child	NNS
cord-356188-rwf78stz	305	1	Herd	herd	VB
cord-356188-rwf78stz	305	2	immunity	immunity	NN
cord-356188-rwf78stz	305	3	in	in	IN
cord-356188-rwf78stz	305	4	adults	adult	NNS
cord-356188-rwf78stz	305	5	against	against	IN
cord-356188-rwf78stz	305	6	influenza	influenza	NN
cord-356188-rwf78stz	305	7	-	-	HYPH
cord-356188-rwf78stz	305	8	related	relate	VBN
cord-356188-rwf78stz	305	9	illnesses	illness	NNS
cord-356188-rwf78stz	305	10	with	with	IN
cord-356188-rwf78stz	305	11	use	use	NN
cord-356188-rwf78stz	305	12	of	of	IN
cord-356188-rwf78stz	305	13	the	the	DT
cord-356188-rwf78stz	305	14	trivalent	trivalent	JJ
cord-356188-rwf78stz	305	15	-	-	HYPH
cord-356188-rwf78stz	305	16	live	live	JJ
cord-356188-rwf78stz	305	17	attenuated	attenuated	JJ
cord-356188-rwf78stz	305	18	influenza	influenza	NN
cord-356188-rwf78stz	305	19	vaccine	vaccine	NN
cord-356188-rwf78stz	305	20	(	(	-LRB-
cord-356188-rwf78stz	305	21	CAIV	CAIV	NNP
cord-356188-rwf78stz	305	22	-	-	HYPH
cord-356188-rwf78stz	305	23	T	T	NNP
cord-356188-rwf78stz	305	24	)	)	-RRB-
cord-356188-rwf78stz	305	25	in	in	IN
cord-356188-rwf78stz	305	26	children	child	NNS
cord-356188-rwf78stz	305	27	Effectiveness	Effectiveness	NNP
cord-356188-rwf78stz	305	28	of	of	IN
cord-356188-rwf78stz	305	29	influenza	influenza	NN
cord-356188-rwf78stz	305	30	vaccination	vaccination	NN
cord-356188-rwf78stz	305	31	of	of	IN
cord-356188-rwf78stz	305	32	children	child	NNS
cord-356188-rwf78stz	305	33	with	with	IN
cord-356188-rwf78stz	305	34	recurrent	recurrent	JJ
cord-356188-rwf78stz	305	35	respiratory	respiratory	JJ
cord-356188-rwf78stz	305	36	tract	tract	NN
cord-356188-rwf78stz	305	37	infections	infection	NNS
cord-356188-rwf78stz	305	38	in	in	IN
cord-356188-rwf78stz	305	39	reducing	reduce	VBG
cord-356188-rwf78stz	305	40	respiratory	respiratory	NN
cord-356188-rwf78stz	305	41	-	-	HYPH
cord-356188-rwf78stz	305	42	related	relate	VBN
cord-356188-rwf78stz	305	43	morbidity	morbidity	NN
cord-356188-rwf78stz	305	44	within	within	IN
cord-356188-rwf78stz	305	45	the	the	DT
cord-356188-rwf78stz	305	46	households	household	NNS
cord-356188-rwf78stz	306	1	The	the	DT
cord-356188-rwf78stz	306	2	Japanese	japanese	JJ
cord-356188-rwf78stz	306	3	experience	experience	NN
cord-356188-rwf78stz	306	4	with	with	IN
cord-356188-rwf78stz	306	5	vaccinating	vaccinate	VBG
cord-356188-rwf78stz	306	6	schoolchildren	schoolchildren	NNS
cord-356188-rwf78stz	306	7	against	against	IN
cord-356188-rwf78stz	306	8	influenza	influenza	NN
cord-356188-rwf78stz	306	9	Efficacy	Efficacy	NNP
cord-356188-rwf78stz	306	10	and	and	CC
cord-356188-rwf78stz	306	11	effectiveness	effectiveness	NN
cord-356188-rwf78stz	306	12	of	of	IN
cord-356188-rwf78stz	306	13	influenza	influenza	NN
cord-356188-rwf78stz	306	14	vaccines	vaccine	NNS
cord-356188-rwf78stz	306	15	:	:	:
cord-356188-rwf78stz	306	16	a	a	DT
cord-356188-rwf78stz	306	17	systematic	systematic	JJ
cord-356188-rwf78stz	306	18	review	review	NN
cord-356188-rwf78stz	306	19	and	and	CC
cord-356188-rwf78stz	306	20	meta	meta	NNP
cord-356188-rwf78stz	306	21	-	-	HYPH
cord-356188-rwf78stz	306	22	analysis	analysis	NN
cord-356188-rwf78stz	306	23	Mortality	mortality	NN
cord-356188-rwf78stz	306	24	benefits	benefit	NNS
cord-356188-rwf78stz	306	25	of	of	IN
cord-356188-rwf78stz	306	26	influenza	influenza	NN
cord-356188-rwf78stz	306	27	vaccination	vaccination	NN
cord-356188-rwf78stz	306	28	in	in	IN
cord-356188-rwf78stz	306	29	elderly	elderly	JJ
cord-356188-rwf78stz	306	30	people	people	NNS
cord-356188-rwf78stz	306	31	:	:	:
cord-356188-rwf78stz	306	32	an	an	DT
cord-356188-rwf78stz	306	33	ongoing	ongoing	JJ
cord-356188-rwf78stz	306	34	controversy	controversy	NN
cord-356188-rwf78stz	306	35	Influenza	Influenza	NNP
cord-356188-rwf78stz	306	36	vaccination	vaccination	NN
cord-356188-rwf78stz	306	37	and	and	CC
cord-356188-rwf78stz	306	38	mortality	mortality	NN
cord-356188-rwf78stz	306	39	:	:	:
cord-356188-rwf78stz	306	40	differentiating	differentiate	VBG
cord-356188-rwf78stz	306	41	vaccine	vaccine	NN
cord-356188-rwf78stz	306	42	effects	effect	NNS
cord-356188-rwf78stz	306	43	from	from	IN
cord-356188-rwf78stz	306	44	bias	bias	NN
cord-356188-rwf78stz	306	45	Effect	effect	NN
cord-356188-rwf78stz	306	46	of	of	IN
cord-356188-rwf78stz	306	47	influenza	influenza	NN
cord-356188-rwf78stz	306	48	vaccination	vaccination	NN
cord-356188-rwf78stz	306	49	on	on	IN
cord-356188-rwf78stz	306	50	hospitalizations	hospitalization	NNS
cord-356188-rwf78stz	306	51	in	in	IN
cord-356188-rwf78stz	306	52	persons	person	NNS
cord-356188-rwf78stz	306	53	aged	age	VBN
cord-356188-rwf78stz	306	54	50	50	CD
cord-356188-rwf78stz	306	55	years	year	NNS
cord-356188-rwf78stz	306	56	and	and	CC
cord-356188-rwf78stz	306	57	older	old	JJR
cord-356188-rwf78stz	307	1	FluVaxView	FluVaxView	NNP
cord-356188-rwf78stz	307	2	:	:	:
cord-356188-rwf78stz	308	1	Influenza	Influenza	NNP
cord-356188-rwf78stz	308	2	Vaccination	Vaccination	NNP
cord-356188-rwf78stz	308	3	Coverage	Coverage	NNP
cord-356188-rwf78stz	308	4	Influenza	Influenza	NNP
cord-356188-rwf78stz	308	5	vaccine	vaccine	NN
cord-356188-rwf78stz	308	6	:	:	:
cord-356188-rwf78stz	309	1	the	the	DT
cord-356188-rwf78stz	309	2	challenge	challenge	NN
cord-356188-rwf78stz	309	3	of	of	IN
cord-356188-rwf78stz	309	4	antigenic	antigenic	JJ
cord-356188-rwf78stz	309	5	drift	drift	NN
cord-356188-rwf78stz	309	6	Emulsion	Emulsion	NNP
cord-356188-rwf78stz	309	7	-	-	HYPH
cord-356188-rwf78stz	309	8	based	base	VBN
cord-356188-rwf78stz	309	9	adjuvants	adjuvant	NNS
cord-356188-rwf78stz	309	10	for	for	IN
cord-356188-rwf78stz	309	11	improved	improve	VBN
cord-356188-rwf78stz	309	12	influenza	influenza	NN
cord-356188-rwf78stz	309	13	vaccines	vaccine	NNS
cord-356188-rwf78stz	309	14	The	the	DT
cord-356188-rwf78stz	309	15	adjuvanted	adjuvanted	JJ
cord-356188-rwf78stz	309	16	influenza	influenza	NN
cord-356188-rwf78stz	309	17	vaccines	vaccine	NNS
cord-356188-rwf78stz	309	18	with	with	IN
cord-356188-rwf78stz	309	19	novel	novel	JJ
cord-356188-rwf78stz	309	20	adjuvants	adjuvant	NNS
cord-356188-rwf78stz	309	21	:	:	:
cord-356188-rwf78stz	309	22	experience	experience	NN
cord-356188-rwf78stz	309	23	with	with	IN
cord-356188-rwf78stz	309	24	the	the	DT
cord-356188-rwf78stz	309	25	MF59-adjuvanted	MF59-adjuvanted	NNP
cord-356188-rwf78stz	309	26	vaccine	vaccine	NN
cord-356188-rwf78stz	309	27	Trial	trial	NN
cord-356188-rwf78stz	309	28	of	of	IN
cord-356188-rwf78stz	310	1	2009	2009	CD
cord-356188-rwf78stz	310	2	influenza	influenza	NN
cord-356188-rwf78stz	310	3	A	A	NNP
cord-356188-rwf78stz	310	4	(	(	-LRB-
cord-356188-rwf78stz	310	5	H1N1	H1N1	NNP
cord-356188-rwf78stz	310	6	)	)	-RRB-
cord-356188-rwf78stz	310	7	monovalent	monovalent	JJ
cord-356188-rwf78stz	310	8	MF59-adjuvanted	MF59-adjuvanted	NNP
cord-356188-rwf78stz	310	9	vaccine	vaccine	NN
cord-356188-rwf78stz	311	1	MF59	MF59	NNP
cord-356188-rwf78stz	311	2	is	be	VBZ
cord-356188-rwf78stz	311	3	a	a	DT
cord-356188-rwf78stz	311	4	safe	safe	JJ
cord-356188-rwf78stz	311	5	and	and	CC
cord-356188-rwf78stz	311	6	potent	potent	JJ
cord-356188-rwf78stz	311	7	vaccine	vaccine	NN
cord-356188-rwf78stz	311	8	adjuvant	adjuvant	NN
cord-356188-rwf78stz	311	9	that	that	WDT
cord-356188-rwf78stz	311	10	enhances	enhance	VBZ
cord-356188-rwf78stz	311	11	protection	protection	NN
cord-356188-rwf78stz	311	12	against	against	IN
cord-356188-rwf78stz	311	13	influenza	influenza	NN
cord-356188-rwf78stz	311	14	virus	virus	NN
cord-356188-rwf78stz	311	15	infection	infection	NN
cord-356188-rwf78stz	311	16	MF59-adjuvanted	MF59-adjuvanted	NNP
cord-356188-rwf78stz	311	17	influenza	influenza	NN
cord-356188-rwf78stz	311	18	vaccine	vaccine	NN
cord-356188-rwf78stz	311	19	(	(	-LRB-
cord-356188-rwf78stz	311	20	FLUAD	FLUAD	NNP
cord-356188-rwf78stz	311	21	)	)	-RRB-
cord-356188-rwf78stz	311	22	in	in	IN
cord-356188-rwf78stz	311	23	children	child	NNS
cord-356188-rwf78stz	311	24	:	:	:
cord-356188-rwf78stz	311	25	safety	safety	NN
cord-356188-rwf78stz	311	26	and	and	CC
cord-356188-rwf78stz	311	27	immunogenicity	immunogenicity	NN
cord-356188-rwf78stz	311	28	following	follow	VBG
cord-356188-rwf78stz	311	29	a	a	DT
cord-356188-rwf78stz	311	30	second	second	JJ
cord-356188-rwf78stz	311	31	year	year	NN
cord-356188-rwf78stz	311	32	seasonal	seasonal	JJ
cord-356188-rwf78stz	311	33	vaccination	vaccination	NN
cord-356188-rwf78stz	311	34	Enhanced	enhance	VBN
cord-356188-rwf78stz	311	35	immunogenicity	immunogenicity	NN
cord-356188-rwf78stz	311	36	of	of	IN
cord-356188-rwf78stz	311	37	seasonal	seasonal	JJ
cord-356188-rwf78stz	311	38	influenza	influenza	NN
cord-356188-rwf78stz	311	39	vaccines	vaccine	NNS
cord-356188-rwf78stz	311	40	in	in	IN
cord-356188-rwf78stz	311	41	young	young	JJ
cord-356188-rwf78stz	311	42	children	child	NNS
cord-356188-rwf78stz	311	43	using	use	VBG
cord-356188-rwf78stz	311	44	MF59	MF59	NNP
cord-356188-rwf78stz	311	45	adjuvant	adjuvant	JJ
cord-356188-rwf78stz	311	46	.	.	.
cord-356188-rwf78stz	312	1	Pediatr	Pediatr	NNP
cord-356188-rwf78stz	312	2	Oil	Oil	NNP
cord-356188-rwf78stz	312	3	-	-	HYPH
cord-356188-rwf78stz	312	4	in	in	IN
cord-356188-rwf78stz	312	5	-	-	HYPH
cord-356188-rwf78stz	312	6	water	water	NN
cord-356188-rwf78stz	312	7	emulsion	emulsion	NN
cord-356188-rwf78stz	312	8	adjuvant	adjuvant	JJ
cord-356188-rwf78stz	312	9	with	with	IN
cord-356188-rwf78stz	312	10	influenza	influenza	JJ
cord-356188-rwf78stz	312	11	vaccine	vaccine	NN
cord-356188-rwf78stz	312	12	in	in	IN
cord-356188-rwf78stz	312	13	young	young	JJ
cord-356188-rwf78stz	312	14	children	child	NNS
cord-356188-rwf78stz	313	1	Potent	potent	JJ
cord-356188-rwf78stz	313	2	immunogenicity	immunogenicity	NN
cord-356188-rwf78stz	313	3	and	and	CC
cord-356188-rwf78stz	313	4	efficacy	efficacy	NN
cord-356188-rwf78stz	313	5	of	of	IN
cord-356188-rwf78stz	313	6	a	a	DT
cord-356188-rwf78stz	313	7	universal	universal	JJ
cord-356188-rwf78stz	313	8	influenza	influenza	NN
cord-356188-rwf78stz	313	9	vaccine	vaccine	NN
cord-356188-rwf78stz	313	10	candidate	candidate	NN
cord-356188-rwf78stz	313	11	comprising	comprise	VBG
cord-356188-rwf78stz	313	12	a	a	DT
cord-356188-rwf78stz	313	13	recombinant	recombinant	JJ
cord-356188-rwf78stz	313	14	fusion	fusion	NN
cord-356188-rwf78stz	313	15	protein	protein	NN
cord-356188-rwf78stz	313	16	linking	link	VBG
cord-356188-rwf78stz	313	17	influenza	influenza	NN
cord-356188-rwf78stz	313	18	M2e	M2e	VBG
cord-356188-rwf78stz	313	19	to	to	IN
cord-356188-rwf78stz	313	20	the	the	DT
cord-356188-rwf78stz	313	21	TLR5	TLR5	NNP
cord-356188-rwf78stz	313	22	ligand	ligand	NN
cord-356188-rwf78stz	313	23	flagellin	flagellin	NNP
cord-356188-rwf78stz	313	24	Universal	Universal	NNP
cord-356188-rwf78stz	313	25	M2	M2	NNP
cord-356188-rwf78stz	314	1	ectodomain	ectodomain	NNP
cord-356188-rwf78stz	314	2	-	-	HYPH
cord-356188-rwf78stz	314	3	based	base	VBN
cord-356188-rwf78stz	314	4	influenza	influenza	NN
cord-356188-rwf78stz	314	5	A	a	DT
cord-356188-rwf78stz	314	6	vaccines	vaccine	NNS
cord-356188-rwf78stz	314	7	:	:	:
cord-356188-rwf78stz	314	8	preclinical	preclinical	JJ
cord-356188-rwf78stz	314	9	and	and	CC
cord-356188-rwf78stz	314	10	clinical	clinical	JJ
cord-356188-rwf78stz	314	11	developments	development	NNS
cord-356188-rwf78stz	314	12	Safety	safety	NN
cord-356188-rwf78stz	314	13	and	and	CC
cord-356188-rwf78stz	314	14	immunogenicity	immunogenicity	NN
cord-356188-rwf78stz	314	15	of	of	IN
cord-356188-rwf78stz	314	16	a	a	DT
cord-356188-rwf78stz	314	17	recombinant	recombinant	JJ
cord-356188-rwf78stz	314	18	M2e	m2e	NN
cord-356188-rwf78stz	314	19	-	-	HYPH
cord-356188-rwf78stz	314	20	flagellin	flagellin	JJ
cord-356188-rwf78stz	314	21	influenza	influenza	NN
cord-356188-rwf78stz	314	22	vaccine	vaccine	NN
cord-356188-rwf78stz	314	23	(	(	-LRB-
cord-356188-rwf78stz	314	24	STF2.4xM2e	stf2.4xm2e	NN
cord-356188-rwf78stz	314	25	)	)	-RRB-
cord-356188-rwf78stz	314	26	in	in	IN
cord-356188-rwf78stz	314	27	healthy	healthy	JJ
cord-356188-rwf78stz	314	28	adults	adult	NNS
cord-356188-rwf78stz	315	1	A	a	DT
cord-356188-rwf78stz	315	2	highly	highly	RB
cord-356188-rwf78stz	315	3	conserved	conserve	VBN
cord-356188-rwf78stz	315	4	neutralizing	neutralize	VBG
cord-356188-rwf78stz	315	5	epitope	epitope	NN
cord-356188-rwf78stz	315	6	on	on	IN
cord-356188-rwf78stz	315	7	group	group	NN
cord-356188-rwf78stz	316	1	2	2	LS
cord-356188-rwf78stz	316	2	influenza	influenza	NN
cord-356188-rwf78stz	316	3	A	a	DT
cord-356188-rwf78stz	316	4	viruses	virus	NNS
cord-356188-rwf78stz	317	1	A	a	DT
cord-356188-rwf78stz	317	2	neutralizing	neutralize	VBG
cord-356188-rwf78stz	317	3	antibody	antibody	NN
cord-356188-rwf78stz	317	4	selected	select	VBN
cord-356188-rwf78stz	317	5	from	from	IN
cord-356188-rwf78stz	317	6	plasma	plasma	NN
cord-356188-rwf78stz	317	7	cells	cell	NNS
cord-356188-rwf78stz	317	8	that	that	WDT
cord-356188-rwf78stz	317	9	binds	bind	VBZ
cord-356188-rwf78stz	317	10	to	to	IN
cord-356188-rwf78stz	317	11	group	group	NN
cord-356188-rwf78stz	317	12	1	1	CD
cord-356188-rwf78stz	317	13	and	and	CC
cord-356188-rwf78stz	317	14	group	group	NN
cord-356188-rwf78stz	317	15	2	2	CD
cord-356188-rwf78stz	317	16	influenza	influenza	NN
cord-356188-rwf78stz	317	17	A	a	DT
cord-356188-rwf78stz	317	18	hemagglutinins	hemagglutinin	NNS
cord-356188-rwf78stz	317	19	Broadly	broadly	RB
cord-356188-rwf78stz	317	20	neutralizing	neutralize	VBG
cord-356188-rwf78stz	317	21	human	human	JJ
cord-356188-rwf78stz	317	22	antibody	antibody	NN
cord-356188-rwf78stz	317	23	that	that	WDT
cord-356188-rwf78stz	317	24	recognizes	recognize	VBZ
cord-356188-rwf78stz	317	25	the	the	DT
cord-356188-rwf78stz	317	26	receptor	receptor	NN
cord-356188-rwf78stz	317	27	-	-	HYPH
cord-356188-rwf78stz	317	28	binding	bind	VBG
cord-356188-rwf78stz	317	29	pocket	pocket	NN
cord-356188-rwf78stz	317	30	of	of	IN
cord-356188-rwf78stz	317	31	influenza	influenza	NN
cord-356188-rwf78stz	317	32	virus	virus	NN
cord-356188-rwf78stz	317	33	hemagglutinin	hemagglutinin	VBD
cord-356188-rwf78stz	317	34	Antibody	Antibody	NNP
cord-356188-rwf78stz	317	35	recognition	recognition	NN
cord-356188-rwf78stz	317	36	of	of	IN
cord-356188-rwf78stz	317	37	a	a	DT
cord-356188-rwf78stz	317	38	highly	highly	RB
cord-356188-rwf78stz	317	39	conserved	conserve	VBN
cord-356188-rwf78stz	317	40	influenza	influenza	NN
cord-356188-rwf78stz	317	41	virus	virus	NN
cord-356188-rwf78stz	317	42	epitope	epitope	NN
cord-356188-rwf78stz	317	43	Structural	structural	JJ
cord-356188-rwf78stz	317	44	and	and	CC
cord-356188-rwf78stz	317	45	functional	functional	JJ
cord-356188-rwf78stz	317	46	bases	basis	NNS
cord-356188-rwf78stz	317	47	for	for	IN
cord-356188-rwf78stz	317	48	broadspectrum	broadspectrum	NN
cord-356188-rwf78stz	317	49	neutralization	neutralization	NN
cord-356188-rwf78stz	317	50	of	of	IN
cord-356188-rwf78stz	317	51	avian	avian	JJ
cord-356188-rwf78stz	317	52	and	and	CC
cord-356188-rwf78stz	317	53	human	human	JJ
cord-356188-rwf78stz	317	54	influenza	influenza	NN
cord-356188-rwf78stz	317	55	A	a	DT
cord-356188-rwf78stz	317	56	viruses	virus	NNS
cord-356188-rwf78stz	318	1	A	a	DT
cord-356188-rwf78stz	318	2	broadly	broadly	RB
cord-356188-rwf78stz	318	3	neutralizing	neutralize	VBG
cord-356188-rwf78stz	318	4	human	human	JJ
cord-356188-rwf78stz	318	5	monoclonal	monoclonal	JJ
cord-356188-rwf78stz	318	6	antibody	antibody	NN
cord-356188-rwf78stz	318	7	that	that	WDT
cord-356188-rwf78stz	318	8	recognizes	recognize	VBZ
cord-356188-rwf78stz	318	9	a	a	DT
cord-356188-rwf78stz	318	10	conserved	conserved	JJ
cord-356188-rwf78stz	318	11	,	,	,
cord-356188-rwf78stz	318	12	novel	novel	NN
cord-356188-rwf78stz	318	13	epitope	epitope	NN
cord-356188-rwf78stz	318	14	on	on	IN
cord-356188-rwf78stz	318	15	the	the	DT
cord-356188-rwf78stz	318	16	globular	globular	JJ
cord-356188-rwf78stz	318	17	head	head	NN
cord-356188-rwf78stz	318	18	of	of	IN
cord-356188-rwf78stz	318	19	the	the	DT
cord-356188-rwf78stz	318	20	influenza	influenza	NN
cord-356188-rwf78stz	318	21	H1N1	H1N1	NNP
cord-356188-rwf78stz	318	22	virus	virus	NN
cord-356188-rwf78stz	318	23	hemagglutinin	hemagglutinin	VBD
cord-356188-rwf78stz	318	24	Investigation	Investigation	NNP
cord-356188-rwf78stz	318	25	of	of	IN
cord-356188-rwf78stz	318	26	volunteers	volunteer	NNS
cord-356188-rwf78stz	318	27	infected	infect	VBN
cord-356188-rwf78stz	318	28	with	with	IN
cord-356188-rwf78stz	318	29	the	the	DT
cord-356188-rwf78stz	318	30	influenza	influenza	NN
cord-356188-rwf78stz	318	31	virus	virus	NN
cord-356188-rwf78stz	318	32	Comparison	comparison	NN
cord-356188-rwf78stz	318	33	of	of	IN
cord-356188-rwf78stz	318	34	long	long	JJ
cord-356188-rwf78stz	318	35	-	-	HYPH
cord-356188-rwf78stz	318	36	term	term	NN
cord-356188-rwf78stz	318	37	systemic	systemic	JJ
cord-356188-rwf78stz	318	38	and	and	CC
cord-356188-rwf78stz	318	39	secretory	secretory	JJ
cord-356188-rwf78stz	318	40	antibody	antibody	NN
cord-356188-rwf78stz	318	41	responses	response	NNS
cord-356188-rwf78stz	318	42	in	in	IN
cord-356188-rwf78stz	318	43	children	child	NNS
cord-356188-rwf78stz	318	44	given	give	VBN
cord-356188-rwf78stz	318	45	live	live	RB
cord-356188-rwf78stz	318	46	,	,	,
cord-356188-rwf78stz	318	47	attenuated	attenuated	JJ
cord-356188-rwf78stz	318	48	,	,	,
cord-356188-rwf78stz	318	49	or	or	CC
cord-356188-rwf78stz	318	50	inactivated	inactivate	VBN
cord-356188-rwf78stz	319	1	influenza	influenza	NN
cord-356188-rwf78stz	319	2	A	a	DT
cord-356188-rwf78stz	319	3	vaccine	vaccine	NN
cord-356188-rwf78stz	319	4	Immunity	immunity	NN
cord-356188-rwf78stz	319	5	to	to	TO
cord-356188-rwf78stz	319	6	influenza	influenza	VB
cord-356188-rwf78stz	319	7	A	a	DT
cord-356188-rwf78stz	319	8	virus	virus	NN
cord-356188-rwf78stz	319	9	infection	infection	NN
cord-356188-rwf78stz	319	10	in	in	IN
cord-356188-rwf78stz	319	11	young	young	JJ
cord-356188-rwf78stz	319	12	children	child	NNS
cord-356188-rwf78stz	319	13	:	:	:
cord-356188-rwf78stz	319	14	a	a	DT
cord-356188-rwf78stz	319	15	comparison	comparison	NN
cord-356188-rwf78stz	319	16	of	of	IN
cord-356188-rwf78stz	319	17	natural	natural	JJ
cord-356188-rwf78stz	319	18	infection	infection	NN
cord-356188-rwf78stz	319	19	,	,	,
cord-356188-rwf78stz	319	20	live	live	JJ
cord-356188-rwf78stz	319	21	cold	cold	RB
cord-356188-rwf78stz	319	22	-	-	HYPH
cord-356188-rwf78stz	319	23	adapted	adapt	VBN
cord-356188-rwf78stz	319	24	vaccine	vaccine	NN
cord-356188-rwf78stz	319	25	,	,	,
cord-356188-rwf78stz	319	26	and	and	CC
cord-356188-rwf78stz	319	27	inactivated	inactivate	VBN
cord-356188-rwf78stz	319	28	vaccine	vaccine	NN
cord-356188-rwf78stz	319	29	Use	Use	NNP
cord-356188-rwf78stz	319	30	of	of	IN
cord-356188-rwf78stz	319	31	live	live	JJ
cord-356188-rwf78stz	319	32	cold	cold	NN
cord-356188-rwf78stz	319	33	-	-	HYPH
cord-356188-rwf78stz	319	34	adapted	adapt	VBN
cord-356188-rwf78stz	319	35	influenza	influenza	NN
cord-356188-rwf78stz	320	1	A	a	DT
cord-356188-rwf78stz	320	2	H1N1	H1N1	NNP
cord-356188-rwf78stz	320	3	and	and	CC
cord-356188-rwf78stz	320	4	H3N2	H3N2	NNP
cord-356188-rwf78stz	320	5	virus	virus	NN
cord-356188-rwf78stz	320	6	vaccines	vaccine	NNS
cord-356188-rwf78stz	320	7	in	in	IN
cord-356188-rwf78stz	320	8	seropositive	seropositive	JJ
cord-356188-rwf78stz	320	9	adults	adult	NNS
cord-356188-rwf78stz	321	1	New	new	JJ
cord-356188-rwf78stz	321	2	research	research	NN
cord-356188-rwf78stz	321	3	on	on	IN
cord-356188-rwf78stz	321	4	influenza	influenza	NN
cord-356188-rwf78stz	321	5	:	:	:
cord-356188-rwf78stz	321	6	studies	study	NNS
cord-356188-rwf78stz	321	7	with	with	IN
cord-356188-rwf78stz	321	8	normal	normal	JJ
cord-356188-rwf78stz	321	9	volunteers	volunteer	NNS
cord-356188-rwf78stz	321	10	.	.	.
cord-356188-rwf78stz	322	1	Combined	Combined	NNP
cord-356188-rwf78stz	322	2	Clinical	Clinical	NNP
cord-356188-rwf78stz	322	3	Staff	Staff	NNP
cord-356188-rwf78stz	322	4	Conference	Conference	NNP
cord-356188-rwf78stz	322	5	at	at	IN
cord-356188-rwf78stz	322	6	the	the	DT
cord-356188-rwf78stz	322	7	National	National	NNP
cord-356188-rwf78stz	322	8	Institutes	Institutes	NNPS
cord-356188-rwf78stz	322	9	of	of	IN
cord-356188-rwf78stz	322	10	Health	Health	NNP
cord-356188-rwf78stz	322	11	Immune	Immune	NNP
cord-356188-rwf78stz	322	12	correlates	correlate	VBZ
cord-356188-rwf78stz	322	13	of	of	IN
cord-356188-rwf78stz	322	14	protection	protection	NN
cord-356188-rwf78stz	322	15	against	against	IN
cord-356188-rwf78stz	322	16	influenza	influenza	NN
cord-356188-rwf78stz	322	17	in	in	IN
cord-356188-rwf78stz	322	18	the	the	DT
cord-356188-rwf78stz	322	19	human	human	JJ
cord-356188-rwf78stz	322	20	challenge	challenge	NN
cord-356188-rwf78stz	322	21	model	model	NN
cord-356188-rwf78stz	322	22	Potential	potential	JJ
cord-356188-rwf78stz	322	23	role	role	NN
cord-356188-rwf78stz	322	24	of	of	IN
cord-356188-rwf78stz	322	25	human	human	JJ
cord-356188-rwf78stz	322	26	challenge	challenge	NN
cord-356188-rwf78stz	322	27	studies	study	NNS
cord-356188-rwf78stz	322	28	for	for	IN
cord-356188-rwf78stz	322	29	investigation	investigation	NN
cord-356188-rwf78stz	322	30	of	of	IN
cord-356188-rwf78stz	322	31	influenza	influenza	NN
cord-356188-rwf78stz	322	32	transmission	transmission	NN
cord-356188-rwf78stz	322	33	Partial	partial	JJ
cord-356188-rwf78stz	322	34	protection	protection	NN
cord-356188-rwf78stz	322	35	of	of	IN
cord-356188-rwf78stz	322	36	seasonal	seasonal	JJ
cord-356188-rwf78stz	322	37	trivalent	trivalent	JJ
cord-356188-rwf78stz	322	38	inactivated	inactivate	VBN
cord-356188-rwf78stz	322	39	vaccine	vaccine	NN
cord-356188-rwf78stz	322	40	against	against	IN
cord-356188-rwf78stz	322	41	novel	novel	JJ
cord-356188-rwf78stz	322	42	pandemic	pandemic	NN
cord-356188-rwf78stz	323	1	influenza	influenza	NNP
cord-356188-rwf78stz	323	2	A	A	NNP
cord-356188-rwf78stz	323	3	/	/	SYM
cord-356188-rwf78stz	323	4	H1N1	H1N1	NNP
cord-356188-rwf78stz	323	5	2009	2009	CD
cord-356188-rwf78stz	323	6	:	:	:
cord-356188-rwf78stz	323	7	case	case	NN
cord-356188-rwf78stz	323	8	-	-	HYPH
cord-356188-rwf78stz	323	9	control	control	NN
cord-356188-rwf78stz	323	10	study	study	NN
cord-356188-rwf78stz	323	11	in	in	IN
cord-356188-rwf78stz	323	12	Mexico	Mexico	NNP
cord-356188-rwf78stz	323	13	City	City	NNP
cord-356188-rwf78stz	323	14	Seasonal	Seasonal	NNP
cord-356188-rwf78stz	323	15	influenza	influenza	NN
cord-356188-rwf78stz	323	16	vaccine	vaccine	NN
cord-356188-rwf78stz	323	17	and	and	CC
cord-356188-rwf78stz	323	18	protection	protection	NN
cord-356188-rwf78stz	323	19	against	against	IN
cord-356188-rwf78stz	323	20	pandemic	pandemic	NN
cord-356188-rwf78stz	323	21	(	(	-LRB-
cord-356188-rwf78stz	323	22	H1N1	H1N1	NNP
cord-356188-rwf78stz	323	23	)	)	-RRB-
cord-356188-rwf78stz	324	1	2009-associated	2009-associated	CD
cord-356188-rwf78stz	324	2	illness	illness	NN
cord-356188-rwf78stz	324	3	among	among	IN
cord-356188-rwf78stz	324	4	US	US	NNP
cord-356188-rwf78stz	324	5	military	military	NN
cord-356188-rwf78stz	324	6	personnel	personnel	NNS
cord-356188-rwf78stz	324	7	Protective	protective	JJ
cord-356188-rwf78stz	324	8	efficacy	efficacy	NN
cord-356188-rwf78stz	324	9	of	of	IN
cord-356188-rwf78stz	324	10	seasonal	seasonal	JJ
cord-356188-rwf78stz	324	11	influenza	influenza	NN
cord-356188-rwf78stz	324	12	vaccination	vaccination	NN
cord-356188-rwf78stz	324	13	against	against	IN
cord-356188-rwf78stz	324	14	seasonal	seasonal	JJ
cord-356188-rwf78stz	324	15	and	and	CC
cord-356188-rwf78stz	324	16	pandemic	pandemic	NN
cord-356188-rwf78stz	324	17	influenza	influenza	NN
cord-356188-rwf78stz	324	18	virus	virus	NN
cord-356188-rwf78stz	324	19	infection	infection	NN
cord-356188-rwf78stz	324	20	during	during	IN
cord-356188-rwf78stz	324	21	2009	2009	CD
cord-356188-rwf78stz	324	22	in	in	IN
cord-356188-rwf78stz	324	23	Hong	Hong	NNP
cord-356188-rwf78stz	324	24	Kong	Kong	NNP
cord-356188-rwf78stz	324	25	Prior	Prior	NNP
cord-356188-rwf78stz	324	26	H1N1	H1N1	NNP
cord-356188-rwf78stz	324	27	influenza	influenza	NN
cord-356188-rwf78stz	324	28	infection	infection	NN
cord-356188-rwf78stz	324	29	and	and	CC
cord-356188-rwf78stz	324	30	susceptibility	susceptibility	NN
cord-356188-rwf78stz	324	31	of	of	IN
cord-356188-rwf78stz	324	32	Cleveland	Cleveland	NNP
cord-356188-rwf78stz	324	33	Family	Family	NNP
cord-356188-rwf78stz	324	34	Study	Study	NNP
cord-356188-rwf78stz	324	35	participants	participant	NNS
cord-356188-rwf78stz	324	36	during	during	IN
cord-356188-rwf78stz	324	37	the	the	DT
cord-356188-rwf78stz	324	38	H2N2	H2N2	NNP
cord-356188-rwf78stz	324	39	pandemic	pandemic	NN
cord-356188-rwf78stz	324	40	of	of	IN
cord-356188-rwf78stz	324	41	1957	1957	CD
cord-356188-rwf78stz	324	42	:	:	:
cord-356188-rwf78stz	325	1	an	an	DT
cord-356188-rwf78stz	325	2	experiment	experiment	NN
cord-356188-rwf78stz	325	3	of	of	IN
cord-356188-rwf78stz	325	4	nature	nature	JJ
cord-356188-rwf78stz	325	5	Cross	Cross	NNP
cord-356188-rwf78stz	325	6	-	-	JJ
cord-356188-rwf78stz	325	7	subtype	subtype	NN
cord-356188-rwf78stz	325	8	protection	protection	NN
cord-356188-rwf78stz	325	9	in	in	IN
cord-356188-rwf78stz	325	10	humans	human	NNS
cord-356188-rwf78stz	325	11	during	during	IN
cord-356188-rwf78stz	325	12	sequential	sequential	JJ
cord-356188-rwf78stz	325	13	,	,	,
cord-356188-rwf78stz	325	14	overlapping	overlap	VBG
cord-356188-rwf78stz	325	15	,	,	,
cord-356188-rwf78stz	325	16	and/or	and/or	CC
cord-356188-rwf78stz	325	17	concurrent	concurrent	JJ
cord-356188-rwf78stz	325	18	epidemics	epidemic	NNS
cord-356188-rwf78stz	325	19	caused	cause	VBN
cord-356188-rwf78stz	325	20	by	by	IN
cord-356188-rwf78stz	325	21	H3N2	H3N2	NNP
cord-356188-rwf78stz	325	22	and	and	CC
cord-356188-rwf78stz	325	23	H1N1	H1N1	NNP
cord-356188-rwf78stz	325	24	influenza	influenza	NN
cord-356188-rwf78stz	325	25	viruses	viruse	VBZ
cord-356188-rwf78stz	325	26	Kinetics	kinetic	NNS
cord-356188-rwf78stz	325	27	of	of	IN
cord-356188-rwf78stz	325	28	viral	viral	JJ
cord-356188-rwf78stz	325	29	shedding	shedding	NN
cord-356188-rwf78stz	325	30	and	and	CC
cord-356188-rwf78stz	325	31	immune	immune	JJ
cord-356188-rwf78stz	325	32	responses	response	NNS
cord-356188-rwf78stz	325	33	in	in	IN
cord-356188-rwf78stz	325	34	adults	adult	NNS
cord-356188-rwf78stz	325	35	following	follow	VBG
cord-356188-rwf78stz	325	36	administration	administration	NN
cord-356188-rwf78stz	325	37	of	of	IN
cord-356188-rwf78stz	325	38	cold	cold	RB
cord-356188-rwf78stz	325	39	-	-	HYPH
cord-356188-rwf78stz	325	40	adapted	adapt	VBN
cord-356188-rwf78stz	325	41	influenza	influenza	NN
cord-356188-rwf78stz	325	42	vaccine	vaccine	NN
cord-356188-rwf78stz	325	43	Heterosubtypic	Heterosubtypic	NNP
cord-356188-rwf78stz	325	44	neutralizing	neutralize	VBG
cord-356188-rwf78stz	325	45	antibodies	antibody	NNS
cord-356188-rwf78stz	325	46	are	be	VBP
cord-356188-rwf78stz	325	47	produced	produce	VBN
cord-356188-rwf78stz	325	48	by	by	IN
cord-356188-rwf78stz	325	49	individuals	individual	NNS
cord-356188-rwf78stz	325	50	immunized	immunize	VBN
cord-356188-rwf78stz	325	51	with	with	IN
cord-356188-rwf78stz	325	52	a	a	DT
cord-356188-rwf78stz	325	53	seasonal	seasonal	JJ
cord-356188-rwf78stz	325	54	influenza	influenza	NN
cord-356188-rwf78stz	325	55	vaccine	vaccine	NN
cord-356188-rwf78stz	325	56	Broadly	broadly	RB
cord-356188-rwf78stz	325	57	cross	cross	JJ
cord-356188-rwf78stz	325	58	-	-	JJ
cord-356188-rwf78stz	325	59	reactive	reactive	JJ
cord-356188-rwf78stz	325	60	antibodies	antibody	NNS
cord-356188-rwf78stz	325	61	dominate	dominate	VBP
cord-356188-rwf78stz	325	62	the	the	DT
cord-356188-rwf78stz	325	63	human	human	NN
cord-356188-rwf78stz	325	64	B	B	NNP
cord-356188-rwf78stz	325	65	cell	cell	NN
cord-356188-rwf78stz	325	66	response	response	NN
cord-356188-rwf78stz	325	67	against	against	IN
cord-356188-rwf78stz	325	68	2009	2009	CD
cord-356188-rwf78stz	325	69	pandemic	pandemic	NN
cord-356188-rwf78stz	325	70	H1N1	H1N1	NNP
cord-356188-rwf78stz	325	71	influenza	influenza	NN
cord-356188-rwf78stz	325	72	virus	virus	NN
cord-356188-rwf78stz	325	73	infection	infection	NN
cord-356188-rwf78stz	325	74	Neutralizing	neutralize	VBG
cord-356188-rwf78stz	325	75	antibodies	antibody	NNS
cord-356188-rwf78stz	325	76	derived	derive	VBN
cord-356188-rwf78stz	325	77	from	from	IN
cord-356188-rwf78stz	325	78	the	the	DT
cord-356188-rwf78stz	325	79	B	b	NN
cord-356188-rwf78stz	325	80	cells	cell	NNS
cord-356188-rwf78stz	325	81	of	of	IN
cord-356188-rwf78stz	325	82	1918	1918	CD
cord-356188-rwf78stz	325	83	influenza	influenza	NN
cord-356188-rwf78stz	325	84	pandemic	pandemic	NN
cord-356188-rwf78stz	325	85	survivors	survivor	NNS
cord-356188-rwf78stz	325	86	Naturally	naturally	RB
cord-356188-rwf78stz	325	87	occurring	occur	VBG
cord-356188-rwf78stz	325	88	human	human	JJ
cord-356188-rwf78stz	325	89	monoclonal	monoclonal	JJ
cord-356188-rwf78stz	325	90	antibodies	antibody	NNS
cord-356188-rwf78stz	325	91	neutralize	neutralize	VBP
cord-356188-rwf78stz	325	92	both	both	DT
cord-356188-rwf78stz	325	93	1918	1918	CD
cord-356188-rwf78stz	325	94	and	and	CC
cord-356188-rwf78stz	325	95	2009	2009	CD
cord-356188-rwf78stz	325	96	pandemic	pandemic	NN
cord-356188-rwf78stz	325	97	influenza	influenza	NN
cord-356188-rwf78stz	325	98	A	A	NNP
cord-356188-rwf78stz	325	99	(	(	-LRB-
cord-356188-rwf78stz	325	100	H1N1	H1N1	NNP
cord-356188-rwf78stz	325	101	)	)	-RRB-
cord-356188-rwf78stz	325	102	viruses	viruse	VBZ
cord-356188-rwf78stz	325	103	Memory	Memory	NNP
cord-356188-rwf78stz	325	104	T	T	NNP
cord-356188-rwf78stz	325	105	cells	cell	NNS
cord-356188-rwf78stz	325	106	established	establish	VBN
cord-356188-rwf78stz	325	107	by	by	IN
cord-356188-rwf78stz	325	108	seasonal	seasonal	JJ
cord-356188-rwf78stz	325	109	human	human	JJ
cord-356188-rwf78stz	325	110	influenza	influenza	NN
cord-356188-rwf78stz	325	111	A	a	DT
cord-356188-rwf78stz	325	112	infection	infection	NN
cord-356188-rwf78stz	325	113	cross	cross	NN
cord-356188-rwf78stz	325	114	-	-	NN
cord-356188-rwf78stz	325	115	react	react	VB
cord-356188-rwf78stz	325	116	with	with	IN
cord-356188-rwf78stz	325	117	avian	avian	JJ
cord-356188-rwf78stz	325	118	influenza	influenza	NN
cord-356188-rwf78stz	325	119	A	a	NN
cord-356188-rwf78stz	325	120	(	(	-LRB-
cord-356188-rwf78stz	325	121	H5N1	H5N1	NNP
cord-356188-rwf78stz	325	122	)	)	-RRB-
cord-356188-rwf78stz	325	123	in	in	IN
cord-356188-rwf78stz	325	124	healthy	healthy	JJ
cord-356188-rwf78stz	325	125	individuals	individual	NNS
cord-356188-rwf78stz	325	126	Cutting	cut	VBG
cord-356188-rwf78stz	325	127	edge	edge	NN
cord-356188-rwf78stz	325	128	:	:	:
cord-356188-rwf78stz	325	129	CD4	CD4	NNP
cord-356188-rwf78stz	325	130	T	T	NNP
cord-356188-rwf78stz	325	131	cells	cell	NNS
cord-356188-rwf78stz	325	132	generated	generate	VBN
cord-356188-rwf78stz	325	133	from	from	IN
cord-356188-rwf78stz	325	134	encounter	encounter	NN
cord-356188-rwf78stz	325	135	with	with	IN
cord-356188-rwf78stz	325	136	seasonal	seasonal	JJ
cord-356188-rwf78stz	325	137	influenza	influenza	NN
cord-356188-rwf78stz	325	138	viruses	virus	NNS
cord-356188-rwf78stz	325	139	and	and	CC
cord-356188-rwf78stz	325	140	vaccines	vaccine	NNS
cord-356188-rwf78stz	325	141	have	have	VBP
cord-356188-rwf78stz	325	142	broad	broad	JJ
cord-356188-rwf78stz	325	143	protein	protein	NN
cord-356188-rwf78stz	325	144	specificity	specificity	NN
cord-356188-rwf78stz	325	145	and	and	CC
cord-356188-rwf78stz	325	146	can	can	MD
cord-356188-rwf78stz	325	147	directly	directly	RB
cord-356188-rwf78stz	325	148	recognize	recognize	VB
cord-356188-rwf78stz	325	149	naturally	naturally	RB
cord-356188-rwf78stz	325	150	generated	generate	VBN
cord-356188-rwf78stz	325	151	epitopes	epitope	NNS
cord-356188-rwf78stz	325	152	derived	derive	VBN
cord-356188-rwf78stz	325	153	from	from	IN
cord-356188-rwf78stz	325	154	the	the	DT
cord-356188-rwf78stz	325	155	live	live	JJ
cord-356188-rwf78stz	325	156	pandemic	pandemic	NN
cord-356188-rwf78stz	325	157	H1N1	H1N1	NNP
cord-356188-rwf78stz	325	158	virus	virus	NN
cord-356188-rwf78stz	326	1	In	in	IN
cord-356188-rwf78stz	326	2	vitro	vitro	FW
cord-356188-rwf78stz	326	3	responses	response	NNS
cord-356188-rwf78stz	326	4	to	to	IN
cord-356188-rwf78stz	326	5	avian	avian	JJ
cord-356188-rwf78stz	326	6	influenza	influenza	NN
cord-356188-rwf78stz	326	7	H5	H5	NNP
cord-356188-rwf78stz	326	8	by	by	IN
cord-356188-rwf78stz	326	9	human	human	NN
cord-356188-rwf78stz	326	10	CD4	CD4	NNP
cord-356188-rwf78stz	326	11	T	T	NNP
cord-356188-rwf78stz	326	12	cells	cell	VBZ
cord-356188-rwf78stz	326	13	Assessment	Assessment	NNP
cord-356188-rwf78stz	326	14	of	of	IN
cord-356188-rwf78stz	326	15	seasonal	seasonal	JJ
cord-356188-rwf78stz	326	16	influenza	influenza	NN
cord-356188-rwf78stz	326	17	A	a	DT
cord-356188-rwf78stz	326	18	virus	virus	NN
cord-356188-rwf78stz	326	19	-	-	HYPH
cord-356188-rwf78stz	326	20	specific	specific	JJ
cord-356188-rwf78stz	326	21	CD4	CD4	NNP
cord-356188-rwf78stz	326	22	T	t	NN
cord-356188-rwf78stz	326	23	-	-	HYPH
cord-356188-rwf78stz	326	24	cell	cell	NN
cord-356188-rwf78stz	326	25	responses	response	NNS
cord-356188-rwf78stz	326	26	to	to	IN
cord-356188-rwf78stz	326	27	2009	2009	CD
cord-356188-rwf78stz	326	28	pandemic	pandemic	NN
cord-356188-rwf78stz	326	29	H1N1	H1N1	NNP
cord-356188-rwf78stz	326	30	swine	swine	NN
cord-356188-rwf78stz	326	31	-	-	HYPH
cord-356188-rwf78stz	326	32	origin	origin	NN
cord-356188-rwf78stz	327	1	influenza	influenza	NN
cord-356188-rwf78stz	327	2	A	a	DT
cord-356188-rwf78stz	327	3	virus	virus	NN
cord-356188-rwf78stz	327	4	Local	local	JJ
cord-356188-rwf78stz	327	5	and	and	CC
cord-356188-rwf78stz	327	6	systemic	systemic	JJ
cord-356188-rwf78stz	327	7	cytokine	cytokine	JJ
cord-356188-rwf78stz	327	8	responses	response	NNS
cord-356188-rwf78stz	327	9	during	during	IN
cord-356188-rwf78stz	327	10	experimental	experimental	JJ
cord-356188-rwf78stz	327	11	human	human	JJ
cord-356188-rwf78stz	327	12	influenza	influenza	NN
cord-356188-rwf78stz	327	13	A	a	DT
cord-356188-rwf78stz	327	14	virus	virus	NN
cord-356188-rwf78stz	327	15	infection	infection	NN
cord-356188-rwf78stz	327	16	.	.	.
cord-356188-rwf78stz	328	1	Relation	relation	NN
cord-356188-rwf78stz	328	2	to	to	IN
cord-356188-rwf78stz	328	3	symptom	symptom	NN
cord-356188-rwf78stz	328	4	formation	formation	NN
cord-356188-rwf78stz	328	5	and	and	CC
cord-356188-rwf78stz	328	6	host	host	NN
cord-356188-rwf78stz	328	7	defense	defense	NN
cord-356188-rwf78stz	328	8	Re	re	NN
cord-356188-rwf78stz	328	9	-	-	NN
cord-356188-rwf78stz	328	10	emergence	emergence	NN
cord-356188-rwf78stz	328	11	of	of	IN
cord-356188-rwf78stz	328	12	fatal	fatal	JJ
cord-356188-rwf78stz	328	13	human	human	JJ
cord-356188-rwf78stz	328	14	influenza	influenza	NN
cord-356188-rwf78stz	328	15	A	a	DT
cord-356188-rwf78stz	328	16	subtype	subtype	NN
cord-356188-rwf78stz	329	1	H5N1	H5N1	NNP
cord-356188-rwf78stz	329	2	disease	disease	NN
cord-356188-rwf78stz	330	1	Interleukin	interleukin	NN
cord-356188-rwf78stz	330	2	8	8	CD
cord-356188-rwf78stz	330	3	(	(	-LRB-
cord-356188-rwf78stz	330	4	IL-8	IL-8	NNP
cord-356188-rwf78stz	330	5	)	)	-RRB-
cord-356188-rwf78stz	330	6	in	in	IN
cord-356188-rwf78stz	330	7	the	the	DT
cord-356188-rwf78stz	330	8	bronchoalveolar	bronchoalveolar	NNP
cord-356188-rwf78stz	330	9	lavage	lavage	NN
cord-356188-rwf78stz	330	10	fluid	fluid	NN
cord-356188-rwf78stz	330	11	from	from	IN
cord-356188-rwf78stz	330	12	patients	patient	NNS
cord-356188-rwf78stz	330	13	with	with	IN
cord-356188-rwf78stz	330	14	the	the	DT
cord-356188-rwf78stz	330	15	adult	adult	NN
cord-356188-rwf78stz	330	16	respiratory	respiratory	JJ
cord-356188-rwf78stz	330	17	distress	distress	NN
cord-356188-rwf78stz	330	18	syndrome	syndrome	NN
cord-356188-rwf78stz	330	19	(	(	-LRB-
cord-356188-rwf78stz	330	20	ARDS	ARDS	NNP
cord-356188-rwf78stz	330	21	)	)	-RRB-
cord-356188-rwf78stz	330	22	and	and	CC
cord-356188-rwf78stz	330	23	patients	patient	NNS
cord-356188-rwf78stz	330	24	at	at	IN
cord-356188-rwf78stz	330	25	risk	risk	NN
cord-356188-rwf78stz	330	26	for	for	IN
cord-356188-rwf78stz	330	27	ARDS	ARDS	NNP
cord-356188-rwf78stz	330	28	A	a	DT
cord-356188-rwf78stz	330	29	comparison	comparison	NN
cord-356188-rwf78stz	330	30	of	of	IN
cord-356188-rwf78stz	330	31	cytokine	cytokine	JJ
cord-356188-rwf78stz	330	32	responses	response	NNS
cord-356188-rwf78stz	330	33	in	in	IN
cord-356188-rwf78stz	330	34	respiratory	respiratory	JJ
cord-356188-rwf78stz	330	35	syncytial	syncytial	JJ
cord-356188-rwf78stz	330	36	virus	virus	NN
cord-356188-rwf78stz	330	37	and	and	CC
cord-356188-rwf78stz	330	38	influenza	influenza	NN
cord-356188-rwf78stz	330	39	A	a	DT
cord-356188-rwf78stz	330	40	infections	infection	NNS
cord-356188-rwf78stz	330	41	in	in	IN
cord-356188-rwf78stz	330	42	infants	infant	NNS
cord-356188-rwf78stz	330	43	Differential	differential	JJ
cord-356188-rwf78stz	330	44	production	production	NN
cord-356188-rwf78stz	330	45	of	of	IN
cord-356188-rwf78stz	330	46	inflammatory	inflammatory	JJ
cord-356188-rwf78stz	330	47	cytokines	cytokine	NNS
cord-356188-rwf78stz	330	48	in	in	IN
cord-356188-rwf78stz	330	49	primary	primary	JJ
cord-356188-rwf78stz	330	50	infection	infection	NN
cord-356188-rwf78stz	330	51	with	with	IN
cord-356188-rwf78stz	330	52	human	human	JJ
cord-356188-rwf78stz	330	53	metapneumovirus	metapneumovirus	NN
cord-356188-rwf78stz	330	54	and	and	CC
cord-356188-rwf78stz	330	55	with	with	IN
cord-356188-rwf78stz	330	56	other	other	JJ
cord-356188-rwf78stz	330	57	common	common	JJ
cord-356188-rwf78stz	330	58	respiratory	respiratory	JJ
cord-356188-rwf78stz	330	59	viruses	virus	NNS
cord-356188-rwf78stz	330	60	of	of	IN
cord-356188-rwf78stz	330	61	infancy	infancy	NN
cord-356188-rwf78stz	331	1	Severe	severe	JJ
cord-356188-rwf78stz	331	2	human	human	JJ
cord-356188-rwf78stz	331	3	lower	low	JJR
cord-356188-rwf78stz	331	4	respiratory	respiratory	JJ
cord-356188-rwf78stz	331	5	tract	tract	NN
cord-356188-rwf78stz	331	6	illness	illness	NN
cord-356188-rwf78stz	331	7	caused	cause	VBN
cord-356188-rwf78stz	331	8	by	by	IN
cord-356188-rwf78stz	331	9	respiratory	respiratory	JJ
cord-356188-rwf78stz	331	10	syncytial	syncytial	JJ
cord-356188-rwf78stz	331	11	virus	virus	NN
cord-356188-rwf78stz	331	12	and	and	CC
cord-356188-rwf78stz	331	13	influenza	influenza	NN
cord-356188-rwf78stz	331	14	virus	virus	NN
cord-356188-rwf78stz	331	15	is	be	VBZ
cord-356188-rwf78stz	331	16	characterized	characterize	VBN
cord-356188-rwf78stz	331	17	by	by	IN
cord-356188-rwf78stz	331	18	the	the	DT
cord-356188-rwf78stz	331	19	absence	absence	NN
cord-356188-rwf78stz	331	20	of	of	IN
cord-356188-rwf78stz	331	21	pulmonary	pulmonary	JJ
cord-356188-rwf78stz	331	22	cytotoxic	cytotoxic	JJ
cord-356188-rwf78stz	331	23	lymphocyte	lymphocyte	NN
cord-356188-rwf78stz	331	24	responses	response	NNS
cord-356188-rwf78stz	331	25	A	a	DT
cord-356188-rwf78stz	331	26	comparison	comparison	NN
cord-356188-rwf78stz	331	27	of	of	IN
cord-356188-rwf78stz	331	28	epidemiologic	epidemiologic	JJ
cord-356188-rwf78stz	331	29	and	and	CC
cord-356188-rwf78stz	331	30	immunologic	immunologic	JJ
cord-356188-rwf78stz	331	31	features	feature	NNS
cord-356188-rwf78stz	331	32	of	of	IN
cord-356188-rwf78stz	331	33	bronchiolitis	bronchiolitis	NN
cord-356188-rwf78stz	331	34	caused	cause	VBN
cord-356188-rwf78stz	331	35	by	by	IN
cord-356188-rwf78stz	331	36	influenza	influenza	NN
cord-356188-rwf78stz	331	37	virus	virus	NN
cord-356188-rwf78stz	331	38	and	and	CC
cord-356188-rwf78stz	331	39	respiratory	respiratory	JJ
cord-356188-rwf78stz	331	40	syncytial	syncytial	JJ
cord-356188-rwf78stz	331	41	virus	virus	NN
cord-356188-rwf78stz	331	42	Fatal	fatal	JJ
cord-356188-rwf78stz	331	43	outcome	outcome	NN
cord-356188-rwf78stz	331	44	of	of	IN
cord-356188-rwf78stz	331	45	human	human	JJ
cord-356188-rwf78stz	331	46	influenza	influenza	NN
cord-356188-rwf78stz	331	47	A	a	NN
cord-356188-rwf78stz	331	48	(	(	-LRB-
cord-356188-rwf78stz	331	49	H5N1	H5N1	NNP
cord-356188-rwf78stz	331	50	)	)	-RRB-
cord-356188-rwf78stz	331	51	is	be	VBZ
cord-356188-rwf78stz	331	52	associated	associate	VBN
cord-356188-rwf78stz	331	53	with	with	IN
cord-356188-rwf78stz	331	54	high	high	JJ
cord-356188-rwf78stz	331	55	viral	viral	JJ
cord-356188-rwf78stz	331	56	load	load	NN
cord-356188-rwf78stz	331	57	and	and	CC
cord-356188-rwf78stz	331	58	hypercytokinemia	hypercytokinemia	NNP
cord-356188-rwf78stz	331	59	Analysis	Analysis	NNP
cord-356188-rwf78stz	331	60	of	of	IN
cord-356188-rwf78stz	331	61	cells	cell	NNS
cord-356188-rwf78stz	331	62	obtained	obtain	VBN
cord-356188-rwf78stz	331	63	by	by	IN
cord-356188-rwf78stz	331	64	bronchial	bronchial	JJ
cord-356188-rwf78stz	331	65	lavage	lavage	NN
cord-356188-rwf78stz	331	66	of	of	IN
cord-356188-rwf78stz	331	67	infants	infant	NNS
cord-356188-rwf78stz	331	68	with	with	IN
cord-356188-rwf78stz	331	69	respiratory	respiratory	JJ
cord-356188-rwf78stz	331	70	syncytial	syncytial	JJ
cord-356188-rwf78stz	331	71	virus	virus	NN
cord-356188-rwf78stz	331	72	infection	infection	NN
cord-356188-rwf78stz	331	73	Leucocyte	Leucocyte	NNP
cord-356188-rwf78stz	331	74	populations	population	NNS
cord-356188-rwf78stz	331	75	in	in	IN
cord-356188-rwf78stz	331	76	respiratory	respiratory	JJ
cord-356188-rwf78stz	331	77	syncytial	syncytial	JJ
cord-356188-rwf78stz	331	78	virus	virus	NN
cord-356188-rwf78stz	331	79	-	-	HYPH
cord-356188-rwf78stz	331	80	induced	induce	VBN
cord-356188-rwf78stz	331	81	bronchiolitis	bronchiolitis	NN
cord-356188-rwf78stz	331	82	Chemokine	Chemokine	NNP
cord-356188-rwf78stz	331	83	receptor	receptor	NN
cord-356188-rwf78stz	331	84	expression	expression	NN
cord-356188-rwf78stz	331	85	and	and	CC
cord-356188-rwf78stz	331	86	chemotactic	chemotactic	JJ
cord-356188-rwf78stz	331	87	responsiveness	responsiveness	NN
cord-356188-rwf78stz	331	88	of	of	IN
cord-356188-rwf78stz	331	89	human	human	JJ
cord-356188-rwf78stz	331	90	monocytes	monocyte	NNS
cord-356188-rwf78stz	331	91	after	after	IN
cord-356188-rwf78stz	331	92	influenza	influenza	NN
cord-356188-rwf78stz	331	93	A	a	DT
cord-356188-rwf78stz	331	94	virus	virus	NN
cord-356188-rwf78stz	331	95	infection	infection	NN
cord-356188-rwf78stz	331	96	Avian	avian	JJ
cord-356188-rwf78stz	331	97	influenza	influenza	NN
cord-356188-rwf78stz	331	98	A	a	NN
cord-356188-rwf78stz	331	99	(	(	-LRB-
cord-356188-rwf78stz	331	100	H5N1	H5N1	NNP
cord-356188-rwf78stz	331	101	)	)	-RRB-
cord-356188-rwf78stz	331	102	infection	infection	NN
cord-356188-rwf78stz	331	103	in	in	IN
cord-356188-rwf78stz	331	104	humans	human	NNS
cord-356188-rwf78stz	331	105	Humoral	Humoral	NNP
cord-356188-rwf78stz	331	106	and	and	CC
cord-356188-rwf78stz	331	107	cell	cell	NN
cord-356188-rwf78stz	331	108	-	-	HYPH
cord-356188-rwf78stz	331	109	mediated	mediate	VBN
cord-356188-rwf78stz	331	110	immune	immune	JJ
cord-356188-rwf78stz	331	111	responses	response	NNS
cord-356188-rwf78stz	331	112	to	to	IN
cord-356188-rwf78stz	331	113	monovalent	monovalent	VB
cord-356188-rwf78stz	331	114	2009	2009	CD
cord-356188-rwf78stz	331	115	influenza	influenza	NN
cord-356188-rwf78stz	331	116	A	A	NNP
cord-356188-rwf78stz	331	117	/	/	SYM
cord-356188-rwf78stz	331	118	H1N1	H1N1	NNP
cord-356188-rwf78stz	331	119	and	and	CC
cord-356188-rwf78stz	331	120	seasonal	seasonal	JJ
cord-356188-rwf78stz	331	121	trivalent	trivalent	JJ
cord-356188-rwf78stz	331	122	influenza	influenza	NN
cord-356188-rwf78stz	331	123	vaccines	vaccine	NNS
cord-356188-rwf78stz	331	124	in	in	IN
cord-356188-rwf78stz	331	125	high	high	JJ
cord-356188-rwf78stz	331	126	-	-	HYPH
cord-356188-rwf78stz	331	127	risk	risk	NN
cord-356188-rwf78stz	331	128	children	child	NNS
cord-356188-rwf78stz	332	1	Influenza	Influenza	NNP
cord-356188-rwf78stz	332	2	A	a	DT
cord-356188-rwf78stz	332	3	antigen	antigen	NN
cord-356188-rwf78stz	332	4	exposure	exposure	NN
cord-356188-rwf78stz	332	5	selects	select	VBZ
cord-356188-rwf78stz	332	6	dominant	dominant	JJ
cord-356188-rwf78stz	332	7	V	V	NNP
cord-356188-rwf78stz	332	8	␤	␤	NNP
cord-356188-rwf78stz	332	9	17ϩ	17ϩ	CD
cord-356188-rwf78stz	333	1	TCR	TCR	NNP
cord-356188-rwf78stz	333	2	in	in	IN
cord-356188-rwf78stz	333	3	human	human	JJ
cord-356188-rwf78stz	333	4	CD8ϩ	CD8ϩ	NNP
cord-356188-rwf78stz	333	5	cytotoxic	cytotoxic	JJ
cord-356188-rwf78stz	333	6	T	t	NN
cord-356188-rwf78stz	333	7	cell	cell	NN
cord-356188-rwf78stz	333	8	responses	response	NNS
cord-356188-rwf78stz	334	1	Influenza	influenza	NN
cord-356188-rwf78stz	334	2	-	-	HYPH
cord-356188-rwf78stz	334	3	specific	specific	JJ
cord-356188-rwf78stz	334	4	T	t	NN
cord-356188-rwf78stz	334	5	cells	cell	NNS
cord-356188-rwf78stz	334	6	from	from	IN
cord-356188-rwf78stz	334	7	older	old	JJR
cord-356188-rwf78stz	334	8	people	people	NNS
cord-356188-rwf78stz	334	9	are	be	VBP
cord-356188-rwf78stz	334	10	enriched	enrich	VBN
cord-356188-rwf78stz	334	11	in	in	IN
cord-356188-rwf78stz	334	12	the	the	DT
cord-356188-rwf78stz	334	13	late	late	JJ
cord-356188-rwf78stz	334	14	effector	effector	NN
cord-356188-rwf78stz	334	15	subset	subset	NN
cord-356188-rwf78stz	334	16	and	and	CC
cord-356188-rwf78stz	334	17	their	-PRON-	PRP$
cord-356188-rwf78stz	334	18	presence	presence	NN
cord-356188-rwf78stz	334	19	inversely	inversely	RB
cord-356188-rwf78stz	334	20	correlates	correlate	VBZ
cord-356188-rwf78stz	334	21	with	with	IN
cord-356188-rwf78stz	334	22	vaccine	vaccine	NN
cord-356188-rwf78stz	334	23	response	response	NN
cord-356188-rwf78stz	334	24	Influenza	Influenza	NNP
cord-356188-rwf78stz	334	25	A	a	DT
cord-356188-rwf78stz	334	26	virus	virus	NN
cord-356188-rwf78stz	334	27	specific	specific	JJ
cord-356188-rwf78stz	334	28	T	t	NN
cord-356188-rwf78stz	334	29	cell	cell	NN
cord-356188-rwf78stz	334	30	immunity	immunity	NN
cord-356188-rwf78stz	334	31	in	in	IN
cord-356188-rwf78stz	334	32	humans	human	NNS
cord-356188-rwf78stz	334	33	during	during	IN
cord-356188-rwf78stz	334	34	aging	age	VBG
cord-356188-rwf78stz	334	35	Influenza	Influenza	NNP
cord-356188-rwf78stz	334	36	vaccine	vaccine	NN
cord-356188-rwf78stz	334	37	responses	response	NNS
cord-356188-rwf78stz	334	38	in	in	IN
cord-356188-rwf78stz	334	39	older	old	JJR
cord-356188-rwf78stz	334	40	adults	adult	NNS
cord-356188-rwf78stz	334	41	Role	role	NN
cord-356188-rwf78stz	334	42	of	of	IN
cord-356188-rwf78stz	334	43	humoral	humoral	JJ
cord-356188-rwf78stz	334	44	and	and	CC
cord-356188-rwf78stz	334	45	cell	cell	NN
cord-356188-rwf78stz	334	46	-	-	HYPH
cord-356188-rwf78stz	334	47	mediated	mediate	VBN
cord-356188-rwf78stz	334	48	immunity	immunity	NN
cord-356188-rwf78stz	334	49	in	in	IN
cord-356188-rwf78stz	334	50	protection	protection	NN
cord-356188-rwf78stz	334	51	from	from	IN
cord-356188-rwf78stz	334	52	influenza	influenza	NN
cord-356188-rwf78stz	334	53	disease	disease	NN
cord-356188-rwf78stz	334	54	after	after	IN
cord-356188-rwf78stz	334	55	immunization	immunization	NN
cord-356188-rwf78stz	334	56	of	of	IN
cord-356188-rwf78stz	334	57	healthy	healthy	JJ
cord-356188-rwf78stz	334	58	elderly	elderly	JJ
cord-356188-rwf78stz	334	59	Discordance	discordance	NN
cord-356188-rwf78stz	334	60	between	between	IN
cord-356188-rwf78stz	334	61	antibody	antibody	NN
cord-356188-rwf78stz	334	62	and	and	CC
cord-356188-rwf78stz	334	63	T	t	NN
cord-356188-rwf78stz	334	64	cell	cell	NN
cord-356188-rwf78stz	334	65	responses	response	NNS
cord-356188-rwf78stz	334	66	in	in	IN
cord-356188-rwf78stz	334	67	recipients	recipient	NNS
cord-356188-rwf78stz	334	68	of	of	IN
cord-356188-rwf78stz	334	69	trivalent	trivalent	JJ
cord-356188-rwf78stz	334	70	inactivated	inactivate	VBN
cord-356188-rwf78stz	334	71	influenza	influenza	NN
cord-356188-rwf78stz	334	72	vaccine	vaccine	NN
cord-356188-rwf78stz	334	73	T	T	NNP
cord-356188-rwf78stz	334	74	cell	cell	NN
cord-356188-rwf78stz	334	75	responses	response	NNS
cord-356188-rwf78stz	334	76	are	be	VBP
cord-356188-rwf78stz	334	77	better	well	JJR
cord-356188-rwf78stz	334	78	correlates	correlate	NNS
cord-356188-rwf78stz	334	79	of	of	IN
cord-356188-rwf78stz	334	80	vaccine	vaccine	NN
cord-356188-rwf78stz	334	81	protection	protection	NN
cord-356188-rwf78stz	334	82	in	in	IN
cord-356188-rwf78stz	334	83	the	the	DT
cord-356188-rwf78stz	334	84	elderly	elderly	JJ
cord-356188-rwf78stz	335	1	The	the	DT
cord-356188-rwf78stz	335	2	2009	2009	CD
cord-356188-rwf78stz	335	3	pandemic	pandemic	NN
cord-356188-rwf78stz	335	4	H1N1	H1N1	NNP
cord-356188-rwf78stz	335	5	influenza	influenza	NN
cord-356188-rwf78stz	335	6	and	and	CC
cord-356188-rwf78stz	335	7	indigenous	indigenous	JJ
cord-356188-rwf78stz	335	8	populations	population	NNS
cord-356188-rwf78stz	335	9	of	of	IN
cord-356188-rwf78stz	335	10	the	the	DT
cord-356188-rwf78stz	335	11	Americas	Americas	NNPS
cord-356188-rwf78stz	335	12	and	and	CC
cord-356188-rwf78stz	335	13	the	the	DT
cord-356188-rwf78stz	335	14	Pacific	Pacific	NNP
cord-356188-rwf78stz	335	15	Critical	Critical	NNP
cord-356188-rwf78stz	335	16	care	care	NN
cord-356188-rwf78stz	335	17	services	service	NNS
cord-356188-rwf78stz	335	18	and	and	CC
cord-356188-rwf78stz	335	19	2009	2009	CD
cord-356188-rwf78stz	335	20	H1N1	H1N1	NNP
cord-356188-rwf78stz	335	21	influenza	influenza	NN
cord-356188-rwf78stz	335	22	in	in	IN
cord-356188-rwf78stz	335	23	Australia	Australia	NNP
cord-356188-rwf78stz	335	24	and	and	CC
cord-356188-rwf78stz	335	25	New	New	NNP
cord-356188-rwf78stz	335	26	Zealand	Zealand	NNP
cord-356188-rwf78stz	336	1	Public	Public	NNP
cord-356188-rwf78stz	336	2	Health	Health	NNP
cord-356188-rwf78stz	336	3	Weekly	Weekly	NNP
cord-356188-rwf78stz	336	4	Reports	Reports	NNPS
cord-356188-rwf78stz	336	5	for	for	IN
cord-356188-rwf78stz	336	6	Host	Host	NNP
cord-356188-rwf78stz	336	7	single	single	JJ
cord-356188-rwf78stz	336	8	-	-	HYPH
cord-356188-rwf78stz	336	9	nucleotide	nucleotide	NN
cord-356188-rwf78stz	336	10	polymorphisms	polymorphism	NNS
cord-356188-rwf78stz	336	11	and	and	CC
cord-356188-rwf78stz	336	12	altered	alter	VBN
cord-356188-rwf78stz	336	13	responses	response	NNS
cord-356188-rwf78stz	336	14	to	to	IN
cord-356188-rwf78stz	336	15	inactivated	inactivate	VBN
cord-356188-rwf78stz	336	16	influenza	influenza	NN
cord-356188-rwf78stz	336	17	vaccine	vaccine	NN
cord-356188-rwf78stz	336	18	Genetic	genetic	JJ
cord-356188-rwf78stz	336	19	variants	variant	NNS
cord-356188-rwf78stz	336	20	associated	associate	VBN
cord-356188-rwf78stz	336	21	with	with	IN
cord-356188-rwf78stz	336	22	severe	severe	JJ
cord-356188-rwf78stz	336	23	pneumonia	pneumonia	NN
cord-356188-rwf78stz	336	24	in	in	IN
cord-356188-rwf78stz	336	25	A	A	NNP
cord-356188-rwf78stz	336	26	/	/	SYM
cord-356188-rwf78stz	336	27	H1N1	H1N1	NNP
cord-356188-rwf78stz	336	28	influenza	influenza	NN
cord-356188-rwf78stz	336	29	infection	infection	NN
cord-356188-rwf78stz	336	30	Human	Human	NNP
cord-356188-rwf78stz	336	31	memory	memory	NN
cord-356188-rwf78stz	336	32	CTL	CTL	NNP
cord-356188-rwf78stz	336	33	response	response	NN
cord-356188-rwf78stz	336	34	specific	specific	JJ
cord-356188-rwf78stz	336	35	for	for	IN
cord-356188-rwf78stz	336	36	influenza	influenza	NN
cord-356188-rwf78stz	336	37	A	a	DT
cord-356188-rwf78stz	336	38	virus	virus	NN
cord-356188-rwf78stz	336	39	is	be	VBZ
cord-356188-rwf78stz	336	40	broad	broad	JJ
cord-356188-rwf78stz	336	41	and	and	CC
cord-356188-rwf78stz	336	42	multispecific	multispecific	JJ
cord-356188-rwf78stz	336	43	HLA	HLA	NNP
cord-356188-rwf78stz	336	44	class	class	NN
cord-356188-rwf78stz	337	1	I	-PRON-	PRP
cord-356188-rwf78stz	337	2	molecules	molecule	NNS
cord-356188-rwf78stz	337	3	consistently	consistently	RB
cord-356188-rwf78stz	337	4	present	present	VBP
cord-356188-rwf78stz	337	5	internal	internal	JJ
cord-356188-rwf78stz	337	6	influenza	influenza	NN
cord-356188-rwf78stz	337	7	epitopes	epitope	NNS
cord-356188-rwf78stz	337	8	Immunity	immunity	NN
cord-356188-rwf78stz	337	9	and	and	CC
cord-356188-rwf78stz	337	10	immunopathology	immunopathology	NN
cord-356188-rwf78stz	337	11	to	to	IN
cord-356188-rwf78stz	337	12	viruses	virus	NNS
cord-356188-rwf78stz	338	1	:	:	:
cord-356188-rwf78stz	338	2	what	what	WP
cord-356188-rwf78stz	338	3	decides	decide	VBZ
cord-356188-rwf78stz	338	4	the	the	DT
cord-356188-rwf78stz	338	5	outcome	outcome	NN
cord-356188-rwf78stz	338	6	?	?	.
cord-356188-rwf78stz	339	1	Role	role	NN
cord-356188-rwf78stz	339	2	of	of	IN
cord-356188-rwf78stz	339	3	innate	innate	JJ
cord-356188-rwf78stz	339	4	immune	immune	JJ
cord-356188-rwf78stz	339	5	cells	cell	NNS
cord-356188-rwf78stz	339	6	and	and	CC
cord-356188-rwf78stz	339	7	their	-PRON-	PRP$
cord-356188-rwf78stz	339	8	products	product	NNS
cord-356188-rwf78stz	339	9	in	in	IN
cord-356188-rwf78stz	339	10	lung	lung	NN
cord-356188-rwf78stz	339	11	immunopathology	immunopathology	NN
cord-356188-rwf78stz	339	12	Interactions	interaction	NNS
cord-356188-rwf78stz	339	13	between	between	IN
cord-356188-rwf78stz	339	14	innate	innate	JJ
cord-356188-rwf78stz	339	15	antiviral	antiviral	JJ
cord-356188-rwf78stz	339	16	and	and	CC
cord-356188-rwf78stz	339	17	atopic	atopic	NNP
cord-356188-rwf78stz	339	18	immunoinflammatory	immunoinflammatory	NNP
cord-356188-rwf78stz	339	19	pathways	pathway	NNS
cord-356188-rwf78stz	339	20	precipitate	precipitate	VBP
cord-356188-rwf78stz	339	21	and	and	CC
cord-356188-rwf78stz	339	22	sustain	sustain	VB
cord-356188-rwf78stz	339	23	asthma	asthma	NN
cord-356188-rwf78stz	339	24	exacerbations	exacerbation	NNS
cord-356188-rwf78stz	339	25	in	in	IN
cord-356188-rwf78stz	339	26	children	child	NNS
cord-356188-rwf78stz	340	1	Influenza	influenza	NN
cord-356188-rwf78stz	340	2	virus	virus	NN
cord-356188-rwf78stz	340	3	evades	evade	VBZ
cord-356188-rwf78stz	340	4	innate	innate	JJ
cord-356188-rwf78stz	340	5	and	and	CC
cord-356188-rwf78stz	340	6	adaptive	adaptive	JJ
cord-356188-rwf78stz	340	7	immunity	immunity	NN
cord-356188-rwf78stz	340	8	via	via	IN
cord-356188-rwf78stz	340	9	the	the	DT
cord-356188-rwf78stz	340	10	NS1	ns1	NN
cord-356188-rwf78stz	340	11	protein	protein	NN
cord-356188-rwf78stz	340	12	Pandemic	Pandemic	NNP
cord-356188-rwf78stz	340	13	H1N1	H1N1	NNP
cord-356188-rwf78stz	340	14	2009	2009	CD
cord-356188-rwf78stz	340	15	influenza	influenza	NN
cord-356188-rwf78stz	340	16	A	a	DT
cord-356188-rwf78stz	340	17	virus	virus	NN
cord-356188-rwf78stz	340	18	induces	induce	VBZ
cord-356188-rwf78stz	340	19	weak	weak	JJ
cord-356188-rwf78stz	340	20	cytokine	cytokine	JJ
cord-356188-rwf78stz	340	21	responses	response	NNS
cord-356188-rwf78stz	340	22	in	in	IN
cord-356188-rwf78stz	340	23	human	human	JJ
cord-356188-rwf78stz	340	24	macrophages	macrophage	NNS
cord-356188-rwf78stz	340	25	and	and	CC
cord-356188-rwf78stz	340	26	dendritic	dendritic	JJ
cord-356188-rwf78stz	340	27	cells	cell	NNS
cord-356188-rwf78stz	340	28	and	and	CC
cord-356188-rwf78stz	340	29	is	be	VBZ
cord-356188-rwf78stz	340	30	highly	highly	RB
cord-356188-rwf78stz	340	31	sensitive	sensitive	JJ
cord-356188-rwf78stz	340	32	to	to	IN
cord-356188-rwf78stz	340	33	the	the	DT
cord-356188-rwf78stz	340	34	antiviral	antiviral	JJ
cord-356188-rwf78stz	340	35	actions	action	NNS
cord-356188-rwf78stz	340	36	of	of	IN
cord-356188-rwf78stz	340	37	interferons	interferon	NNS
cord-356188-rwf78stz	340	38	Involvement	Involvement	NNP
cord-356188-rwf78stz	340	39	of	of	IN
cord-356188-rwf78stz	340	40	Toll	Toll	NNP
cord-356188-rwf78stz	340	41	-	-	HYPH
cord-356188-rwf78stz	340	42	like	like	JJ
cord-356188-rwf78stz	340	43	receptor	receptor	NN
cord-356188-rwf78stz	340	44	3	3	CD
cord-356188-rwf78stz	340	45	in	in	IN
cord-356188-rwf78stz	340	46	the	the	DT
cord-356188-rwf78stz	340	47	immune	immune	JJ
cord-356188-rwf78stz	340	48	response	response	NN
cord-356188-rwf78stz	340	49	of	of	IN
cord-356188-rwf78stz	340	50	lung	lung	NN
cord-356188-rwf78stz	340	51	epithelial	epithelial	NN
cord-356188-rwf78stz	340	52	cells	cell	NNS
cord-356188-rwf78stz	340	53	to	to	IN
cord-356188-rwf78stz	340	54	double	double	RB
cord-356188-rwf78stz	340	55	-	-	HYPH
cord-356188-rwf78stz	340	56	stranded	strand	VBN
cord-356188-rwf78stz	340	57	RNA	RNA	NNP
cord-356188-rwf78stz	340	58	and	and	CC
cord-356188-rwf78stz	340	59	influenza	influenza	NN
cord-356188-rwf78stz	340	60	A	a	DT
cord-356188-rwf78stz	340	61	virus	virus	NN
cord-356188-rwf78stz	341	1	Dendritic	dendritic	JJ
cord-356188-rwf78stz	341	2	cells	cell	NNS
cord-356188-rwf78stz	341	3	respond	respond	VBP
cord-356188-rwf78stz	341	4	to	to	IN
cord-356188-rwf78stz	341	5	influenza	influenza	NN
cord-356188-rwf78stz	341	6	virus	virus	NN
cord-356188-rwf78stz	341	7	through	through	IN
cord-356188-rwf78stz	341	8	TLR7-and	TLR7-and	NNP
cord-356188-rwf78stz	341	9	PKR	PKR	NNP
cord-356188-rwf78stz	341	10	-	-	HYPH
cord-356188-rwf78stz	341	11	independent	independent	JJ
cord-356188-rwf78stz	341	12	pathways	pathway	NNS
cord-356188-rwf78stz	341	13	Recognition	Recognition	NNP
cord-356188-rwf78stz	341	14	of	of	IN
cord-356188-rwf78stz	341	15	single	single	RB
cord-356188-rwf78stz	341	16	-	-	HYPH
cord-356188-rwf78stz	341	17	stranded	strand	VBN
cord-356188-rwf78stz	341	18	RNA	RNA	NNP
cord-356188-rwf78stz	341	19	viruses	virus	NNS
cord-356188-rwf78stz	341	20	by	by	IN
cord-356188-rwf78stz	341	21	Toll	toll	NN
cord-356188-rwf78stz	341	22	-	-	HYPH
cord-356188-rwf78stz	341	23	like	like	JJ
cord-356188-rwf78stz	341	24	receptor	receptor	NN
cord-356188-rwf78stz	341	25	7	7	CD
cord-356188-rwf78stz	342	1	Interferon	interferon	NN
cord-356188-rwf78stz	342	2	renders	render	VBZ
cord-356188-rwf78stz	342	3	epithelial	epithelial	JJ
cord-356188-rwf78stz	342	4	cells	cell	NNS
cord-356188-rwf78stz	342	5	of	of	IN
cord-356188-rwf78stz	342	6	the	the	DT
cord-356188-rwf78stz	342	7	respiratory	respiratory	JJ
cord-356188-rwf78stz	342	8	and	and	CC
cord-356188-rwf78stz	342	9	gastrointestinal	gastrointestinal	JJ
cord-356188-rwf78stz	342	10	tracts	tract	NNS
cord-356188-rwf78stz	342	11	resistant	resistant	JJ
cord-356188-rwf78stz	342	12	to	to	IN
cord-356188-rwf78stz	342	13	viral	viral	JJ
cord-356188-rwf78stz	342	14	infections	infection	NNS
cord-356188-rwf78stz	342	15	Evidence	evidence	NN
cord-356188-rwf78stz	342	16	for	for	IN
cord-356188-rwf78stz	342	17	a	a	DT
cord-356188-rwf78stz	342	18	protective	protective	JJ
cord-356188-rwf78stz	342	19	role	role	NN
cord-356188-rwf78stz	342	20	of	of	IN
cord-356188-rwf78stz	342	21	pulmonary	pulmonary	JJ
cord-356188-rwf78stz	342	22	surfactant	surfactant	NN
cord-356188-rwf78stz	342	23	protein	protein	NN
cord-356188-rwf78stz	342	24	D	D	NNP
cord-356188-rwf78stz	342	25	(	(	-LRB-
cord-356188-rwf78stz	342	26	SP	SP	NNP
cord-356188-rwf78stz	342	27	-	-	HYPH
cord-356188-rwf78stz	342	28	D	D	NNP
cord-356188-rwf78stz	342	29	)	)	-RRB-
cord-356188-rwf78stz	342	30	against	against	IN
cord-356188-rwf78stz	342	31	influenza	influenza	NN
cord-356188-rwf78stz	342	32	A	a	DT
cord-356188-rwf78stz	342	33	viruses	virus	NNS
cord-356188-rwf78stz	342	34	Mechanism	Mechanism	NNP
cord-356188-rwf78stz	342	35	of	of	IN
cord-356188-rwf78stz	342	36	binding	binding	NN
cord-356188-rwf78stz	342	37	of	of	IN
cord-356188-rwf78stz	342	38	surfactant	surfactant	NN
cord-356188-rwf78stz	342	39	protein	protein	NN
cord-356188-rwf78stz	342	40	D	d	NN
cord-356188-rwf78stz	342	41	to	to	TO
cord-356188-rwf78stz	342	42	influenza	influenza	VB
cord-356188-rwf78stz	342	43	A	a	DT
cord-356188-rwf78stz	342	44	viruses	virus	NNS
cord-356188-rwf78stz	342	45	:	:	:
cord-356188-rwf78stz	343	1	importance	importance	NN
cord-356188-rwf78stz	343	2	of	of	IN
cord-356188-rwf78stz	343	3	binding	bind	VBG
cord-356188-rwf78stz	343	4	to	to	IN
cord-356188-rwf78stz	343	5	haemagglutinin	haemagglutinin	NNP
cord-356188-rwf78stz	343	6	to	to	IN
cord-356188-rwf78stz	343	7	antiviral	antiviral	JJ
cord-356188-rwf78stz	343	8	activity	activity	NN
cord-356188-rwf78stz	343	9	Surfactant	Surfactant	NNP
cord-356188-rwf78stz	343	10	protein	protein	NN
cord-356188-rwf78stz	343	11	D	d	NN
cord-356188-rwf78stz	343	12	enhances	enhance	VBZ
cord-356188-rwf78stz	343	13	clearance	clearance	NN
cord-356188-rwf78stz	343	14	of	of	IN
cord-356188-rwf78stz	343	15	influenza	influenza	NN
cord-356188-rwf78stz	343	16	A	a	DT
cord-356188-rwf78stz	343	17	virus	virus	NN
cord-356188-rwf78stz	343	18	from	from	IN
cord-356188-rwf78stz	343	19	the	the	DT
cord-356188-rwf78stz	343	20	lung	lung	NN
cord-356188-rwf78stz	343	21	in	in	IN
cord-356188-rwf78stz	343	22	vivo	vivo	NN
cord-356188-rwf78stz	343	23	Absence	absence	NN
cord-356188-rwf78stz	343	24	of	of	IN
cord-356188-rwf78stz	343	25	SP	SP	NNP
cord-356188-rwf78stz	343	26	-	-	HYPH
cord-356188-rwf78stz	343	27	A	A	NNP
cord-356188-rwf78stz	343	28	modulates	modulate	VBZ
cord-356188-rwf78stz	343	29	innate	innate	JJ
cord-356188-rwf78stz	343	30	and	and	CC
cord-356188-rwf78stz	343	31	adaptive	adaptive	JJ
cord-356188-rwf78stz	343	32	defense	defense	NN
cord-356188-rwf78stz	343	33	responses	response	NNS
cord-356188-rwf78stz	343	34	to	to	IN
cord-356188-rwf78stz	343	35	pulmonary	pulmonary	JJ
cord-356188-rwf78stz	343	36	influenza	influenza	NN
cord-356188-rwf78stz	343	37	infection	infection	NN
cord-356188-rwf78stz	343	38	Effects	effect	NNS
cord-356188-rwf78stz	343	39	of	of	IN
cord-356188-rwf78stz	343	40	influenza	influenza	NN
cord-356188-rwf78stz	343	41	A	a	DT
cord-356188-rwf78stz	343	42	virus	virus	NN
cord-356188-rwf78stz	343	43	on	on	IN
cord-356188-rwf78stz	343	44	human	human	JJ
cord-356188-rwf78stz	343	45	neutrophil	neutrophil	NN
cord-356188-rwf78stz	343	46	calcium	calcium	NN
cord-356188-rwf78stz	343	47	metabolism	metabolism	NN
cord-356188-rwf78stz	344	1	The	the	DT
cord-356188-rwf78stz	344	2	peptide	peptide	NN
cord-356188-rwf78stz	344	3	antibiotic	antibiotic	JJ
cord-356188-rwf78stz	344	4	LL-37	LL-37	NNP
cord-356188-rwf78stz	344	5	/	/	SYM
cord-356188-rwf78stz	344	6	hCAP-18	hcap-18	CD
cord-356188-rwf78stz	344	7	is	be	VBZ
cord-356188-rwf78stz	344	8	expressed	express	VBN
cord-356188-rwf78stz	344	9	in	in	IN
cord-356188-rwf78stz	344	10	epithelia	epithelium	NNS
cord-356188-rwf78stz	344	11	of	of	IN
cord-356188-rwf78stz	344	12	the	the	DT
cord-356188-rwf78stz	344	13	human	human	JJ
cord-356188-rwf78stz	344	14	lung	lung	NN
cord-356188-rwf78stz	344	15	where	where	WRB
cord-356188-rwf78stz	344	16	it	-PRON-	PRP
cord-356188-rwf78stz	344	17	has	have	VBZ
cord-356188-rwf78stz	344	18	broad	broad	JJ
cord-356188-rwf78stz	344	19	antimicrobial	antimicrobial	JJ
cord-356188-rwf78stz	344	20	activity	activity	NN
cord-356188-rwf78stz	344	21	at	at	IN
cord-356188-rwf78stz	344	22	the	the	DT
cord-356188-rwf78stz	344	23	airway	airway	NN
cord-356188-rwf78stz	344	24	surface	surface	NN
cord-356188-rwf78stz	345	1	The	the	DT
cord-356188-rwf78stz	345	2	human	human	JJ
cord-356188-rwf78stz	345	3	antimicrobial	antimicrobial	NN
cord-356188-rwf78stz	345	4	and	and	CC
cord-356188-rwf78stz	345	5	chemotactic	chemotactic	JJ
cord-356188-rwf78stz	345	6	peptides	peptide	NNS
cord-356188-rwf78stz	345	7	LL-37	LL-37	NNP
cord-356188-rwf78stz	345	8	and	and	CC
cord-356188-rwf78stz	345	9	␣	␣	JJ
cord-356188-rwf78stz	345	10	-defensins	-defensin	NNS
cord-356188-rwf78stz	345	11	are	be	VBP
cord-356188-rwf78stz	345	12	expressed	express	VBN
cord-356188-rwf78stz	345	13	by	by	IN
cord-356188-rwf78stz	345	14	specific	specific	JJ
cord-356188-rwf78stz	345	15	lymphocyte	lymphocyte	NN
cord-356188-rwf78stz	345	16	and	and	CC
cord-356188-rwf78stz	345	17	monocyte	monocyte	NNP
cord-356188-rwf78stz	345	18	populations	population	NNS
cord-356188-rwf78stz	345	19	Antiviral	antiviral	JJ
cord-356188-rwf78stz	345	20	activity	activity	NN
cord-356188-rwf78stz	345	21	and	and	CC
cord-356188-rwf78stz	345	22	increased	increase	VBN
cord-356188-rwf78stz	345	23	host	host	NN
cord-356188-rwf78stz	345	24	defense	defense	NN
cord-356188-rwf78stz	345	25	against	against	IN
cord-356188-rwf78stz	345	26	influenza	influenza	NN
cord-356188-rwf78stz	345	27	infection	infection	NN
cord-356188-rwf78stz	345	28	elicited	elicit	VBN
cord-356188-rwf78stz	345	29	by	by	IN
cord-356188-rwf78stz	345	30	the	the	DT
cord-356188-rwf78stz	345	31	human	human	JJ
cord-356188-rwf78stz	345	32	cathelicidin	cathelicidin	NN
cord-356188-rwf78stz	345	33	LL-37	LL-37	NNP
cord-356188-rwf78stz	345	34	Interaction	Interaction	NNP
cord-356188-rwf78stz	345	35	of	of	IN
cord-356188-rwf78stz	345	36	human	human	JJ
cord-356188-rwf78stz	345	37	defensins	defensin	NNS
cord-356188-rwf78stz	345	38	with	with	IN
cord-356188-rwf78stz	345	39	Escherichia	Escherichia	NNP
cord-356188-rwf78stz	345	40	coli	coli	NNS
cord-356188-rwf78stz	345	41	.	.	.
cord-356188-rwf78stz	346	1	Mechanism	mechanism	NN
cord-356188-rwf78stz	346	2	of	of	IN
cord-356188-rwf78stz	346	3	bactericidal	bactericidal	JJ
cord-356188-rwf78stz	346	4	activity	activity	NN
cord-356188-rwf78stz	346	5	Elevated	elevate	VBN
cord-356188-rwf78stz	346	6	levels	level	NNS
cord-356188-rwf78stz	346	7	of	of	IN
cord-356188-rwf78stz	346	8	␣	␣	CD
cord-356188-rwf78stz	346	9	-defensins	-defensin	NNS
cord-356188-rwf78stz	346	10	in	in	IN
cord-356188-rwf78stz	346	11	plasma	plasma	NN
cord-356188-rwf78stz	346	12	and	and	CC
cord-356188-rwf78stz	346	13	BAL	bal	NN
cord-356188-rwf78stz	346	14	fluid	fluid	NN
cord-356188-rwf78stz	346	15	of	of	IN
cord-356188-rwf78stz	346	16	patients	patient	NNS
cord-356188-rwf78stz	346	17	with	with	IN
cord-356188-rwf78stz	346	18	active	active	JJ
cord-356188-rwf78stz	346	19	pulmonary	pulmonary	JJ
cord-356188-rwf78stz	346	20	tuberculosis	tuberculosis	NN
cord-356188-rwf78stz	346	21	Monocytechemotactic	monocytechemotactic	JJ
cord-356188-rwf78stz	346	22	activity	activity	NN
cord-356188-rwf78stz	346	23	of	of	IN
cord-356188-rwf78stz	346	24	defensins	defensin	NNS
cord-356188-rwf78stz	346	25	from	from	IN
cord-356188-rwf78stz	346	26	human	human	JJ
cord-356188-rwf78stz	346	27	neutrophils	neutrophil	NNS
cord-356188-rwf78stz	346	28	Mechanisms	Mechanisms	NNPS
cord-356188-rwf78stz	346	29	of	of	IN
cord-356188-rwf78stz	346	30	anti	anti	JJ
cord-356188-rwf78stz	346	31	-	-	JJ
cord-356188-rwf78stz	346	32	influenza	influenza	JJ
cord-356188-rwf78stz	346	33	activity	activity	NN
cord-356188-rwf78stz	346	34	of	of	IN
cord-356188-rwf78stz	346	35	surfactant	surfactant	NN
cord-356188-rwf78stz	346	36	proteins	protein	NNS
cord-356188-rwf78stz	346	37	A	A	NNP
cord-356188-rwf78stz	346	38	and	and	CC
cord-356188-rwf78stz	346	39	D	d	NN
cord-356188-rwf78stz	346	40	:	:	:
cord-356188-rwf78stz	346	41	comparison	comparison	NN
cord-356188-rwf78stz	346	42	with	with	IN
cord-356188-rwf78stz	346	43	serum	serum	NN
cord-356188-rwf78stz	346	44	collectins	collectin	VBZ
cord-356188-rwf78stz	346	45	Direct	direct	JJ
cord-356188-rwf78stz	346	46	inactivation	inactivation	NN
cord-356188-rwf78stz	346	47	of	of	IN
cord-356188-rwf78stz	346	48	viruses	virus	NNS
cord-356188-rwf78stz	346	49	by	by	IN
cord-356188-rwf78stz	346	50	human	human	JJ
cord-356188-rwf78stz	346	51	granulocyte	granulocyte	NN
cord-356188-rwf78stz	346	52	defensins	defensin	NNS
cord-356188-rwf78stz	347	1	␣	␣	NNP
cord-356188-rwf78stz	348	1	-Defensin	-Defensin	NNP
cord-356188-rwf78stz	348	2	inhibits	inhibit	VBZ
cord-356188-rwf78stz	348	3	influenza	influenza	NN
cord-356188-rwf78stz	348	4	virus	virus	NN
cord-356188-rwf78stz	348	5	replication	replication	NN
cord-356188-rwf78stz	348	6	by	by	IN
cord-356188-rwf78stz	348	7	cell	cell	NN
cord-356188-rwf78stz	348	8	-	-	HYPH
cord-356188-rwf78stz	348	9	mediated	mediate	VBN
cord-356188-rwf78stz	348	10	mechanism(s	mechanism(s	NN
cord-356188-rwf78stz	348	11	)	)	-RRB-
cord-356188-rwf78stz	349	1	Blood	blood	NN
cord-356188-rwf78stz	349	2	monocytes	monocyte	NNS
cord-356188-rwf78stz	349	3	consist	consist	VBP
cord-356188-rwf78stz	349	4	of	of	IN
cord-356188-rwf78stz	349	5	two	two	CD
cord-356188-rwf78stz	349	6	principal	principal	JJ
cord-356188-rwf78stz	349	7	subsets	subset	NNS
cord-356188-rwf78stz	349	8	with	with	IN
cord-356188-rwf78stz	349	9	distinct	distinct	JJ
cord-356188-rwf78stz	349	10	migratory	migratory	JJ
cord-356188-rwf78stz	349	11	properties	property	NNS
cord-356188-rwf78stz	350	1	The	the	DT
cord-356188-rwf78stz	350	2	proinflammatory	proinflammatory	JJ
cord-356188-rwf78stz	350	3	CD14ϩCD16ϩDRϩϩ	cd14ϩcd16ϩdrϩϩ	NN
cord-356188-rwf78stz	350	4	monocytes	monocyte	NNS
cord-356188-rwf78stz	350	5	are	be	VBP
cord-356188-rwf78stz	350	6	a	a	DT
cord-356188-rwf78stz	350	7	major	major	JJ
cord-356188-rwf78stz	350	8	source	source	NN
cord-356188-rwf78stz	350	9	of	of	IN
cord-356188-rwf78stz	350	10	TNF	TNF	NNP
cord-356188-rwf78stz	351	1	The	the	DT
cord-356188-rwf78stz	351	2	novel	novel	NN
cord-356188-rwf78stz	351	3	subset	subset	NN
cord-356188-rwf78stz	351	4	of	of	IN
cord-356188-rwf78stz	351	5	CD14ϩ/CD16ϩ	CD14ϩ/CD16ϩ	NNP
cord-356188-rwf78stz	351	6	blood	blood	NN
cord-356188-rwf78stz	351	7	monocytes	monocyte	NNS
cord-356188-rwf78stz	351	8	is	be	VBZ
cord-356188-rwf78stz	351	9	expanded	expand	VBN
cord-356188-rwf78stz	351	10	in	in	IN
cord-356188-rwf78stz	351	11	sepsis	sepsis	NN
cord-356188-rwf78stz	351	12	patients	patient	NNS
cord-356188-rwf78stz	351	13	Human	human	JJ
cord-356188-rwf78stz	351	14	CD14dim	cd14dim	NN
cord-356188-rwf78stz	351	15	monocytes	monocyte	VBZ
cord-356188-rwf78stz	351	16	patrol	patrol	NN
cord-356188-rwf78stz	351	17	and	and	CC
cord-356188-rwf78stz	351	18	sense	sense	NN
cord-356188-rwf78stz	351	19	nucleic	nucleic	JJ
cord-356188-rwf78stz	351	20	acids	acid	NNS
cord-356188-rwf78stz	351	21	and	and	CC
cord-356188-rwf78stz	351	22	viruses	virus	NNS
cord-356188-rwf78stz	351	23	via	via	IN
cord-356188-rwf78stz	351	24	TLR7	TLR7	NNP
cord-356188-rwf78stz	351	25	and	and	CC
cord-356188-rwf78stz	351	26	TLR8	TLR8	NNP
cord-356188-rwf78stz	351	27	receptors	receptor	NNS
cord-356188-rwf78stz	351	28	Differential	differential	JJ
cord-356188-rwf78stz	351	29	regulation	regulation	NN
cord-356188-rwf78stz	351	30	of	of	IN
cord-356188-rwf78stz	351	31	Toll	toll	NN
cord-356188-rwf78stz	351	32	-	-	HYPH
cord-356188-rwf78stz	351	33	like	like	JJ
cord-356188-rwf78stz	351	34	receptor-2	receptor-2	NNP
cord-356188-rwf78stz	351	35	,	,	,
cord-356188-rwf78stz	352	1	Toll	toll	NN
cord-356188-rwf78stz	352	2	-	-	HYPH
cord-356188-rwf78stz	352	3	like	like	JJ
cord-356188-rwf78stz	352	4	receptor-4	receptor-4	NNP
cord-356188-rwf78stz	352	5	,	,	,
cord-356188-rwf78stz	352	6	CD16	CD16	NNP
cord-356188-rwf78stz	352	7	and	and	CC
cord-356188-rwf78stz	352	8	human	human	JJ
cord-356188-rwf78stz	352	9	leucocyte	leucocyte	NNP
cord-356188-rwf78stz	352	10	antigen	antigen	NNP
cord-356188-rwf78stz	352	11	-	-	HYPH
cord-356188-rwf78stz	352	12	DR	DR	NNP
cord-356188-rwf78stz	352	13	on	on	IN
cord-356188-rwf78stz	352	14	peripheral	peripheral	JJ
cord-356188-rwf78stz	352	15	blood	blood	NN
cord-356188-rwf78stz	352	16	monocytes	monocyte	NNS
cord-356188-rwf78stz	352	17	during	during	IN
cord-356188-rwf78stz	352	18	mild	mild	JJ
cord-356188-rwf78stz	352	19	and	and	CC
cord-356188-rwf78stz	352	20	severe	severe	JJ
cord-356188-rwf78stz	352	21	dengue	dengue	NN
cord-356188-rwf78stz	352	22	fever	fever	NN
cord-356188-rwf78stz	352	23	Identification	identification	NN
cord-356188-rwf78stz	352	24	of	of	IN
cord-356188-rwf78stz	352	25	a	a	DT
cord-356188-rwf78stz	352	26	novel	novel	JJ
cord-356188-rwf78stz	352	27	dendritic	dendritic	JJ
cord-356188-rwf78stz	352	28	cell	cell	NN
cord-356188-rwf78stz	352	29	-	-	HYPH
cord-356188-rwf78stz	352	30	like	like	JJ
cord-356188-rwf78stz	352	31	subset	subset	NN
cord-356188-rwf78stz	352	32	of	of	IN
cord-356188-rwf78stz	352	33	CD64(ϩ)/CD16(ϩ	cd64(ϩ)/cd16(ϩ	NN
cord-356188-rwf78stz	353	1	)	)	-RRB-
cord-356188-rwf78stz	353	2	blood	blood	NN
cord-356188-rwf78stz	353	3	monocytes	monocyte	VBZ
cord-356188-rwf78stz	353	4	Characterization	characterization	NN
cord-356188-rwf78stz	353	5	of	of	IN
cord-356188-rwf78stz	353	6	myeloid	myeloid	NN
cord-356188-rwf78stz	353	7	and	and	CC
cord-356188-rwf78stz	353	8	plasmacytoid	plasmacytoid	NN
cord-356188-rwf78stz	353	9	dendritic	dendritic	JJ
cord-356188-rwf78stz	353	10	cells	cell	NNS
cord-356188-rwf78stz	353	11	in	in	IN
cord-356188-rwf78stz	353	12	human	human	JJ
cord-356188-rwf78stz	353	13	lung	lung	NN
cord-356188-rwf78stz	353	14	Differential	Differential	NNP
cord-356188-rwf78stz	353	15	recruitment	recruitment	NN
cord-356188-rwf78stz	353	16	of	of	IN
cord-356188-rwf78stz	353	17	dendritic	dendritic	JJ
cord-356188-rwf78stz	353	18	cells	cell	NNS
cord-356188-rwf78stz	353	19	and	and	CC
cord-356188-rwf78stz	353	20	monocytes	monocyte	VBZ
cord-356188-rwf78stz	353	21	to	to	IN
cord-356188-rwf78stz	353	22	respiratory	respiratory	JJ
cord-356188-rwf78stz	353	23	mucosal	mucosal	JJ
cord-356188-rwf78stz	353	24	sites	site	NNS
cord-356188-rwf78stz	353	25	in	in	IN
cord-356188-rwf78stz	353	26	children	child	NNS
cord-356188-rwf78stz	353	27	with	with	IN
cord-356188-rwf78stz	353	28	influenza	influenza	NN
cord-356188-rwf78stz	353	29	virus	virus	NN
cord-356188-rwf78stz	353	30	or	or	CC
cord-356188-rwf78stz	353	31	respiratory	respiratory	JJ
cord-356188-rwf78stz	353	32	syncytial	syncytial	JJ
cord-356188-rwf78stz	353	33	virus	virus	NN
cord-356188-rwf78stz	353	34	infection	infection	NN
cord-356188-rwf78stz	354	1	The	the	DT
cord-356188-rwf78stz	354	2	multifunctional	multifunctional	JJ
cord-356188-rwf78stz	354	3	NS1	ns1	NN
cord-356188-rwf78stz	354	4	protein	protein	NN
cord-356188-rwf78stz	354	5	of	of	IN
cord-356188-rwf78stz	354	6	influenza	influenza	NN
cord-356188-rwf78stz	354	7	A	a	DT
cord-356188-rwf78stz	354	8	viruses	virus	NNS
cord-356188-rwf78stz	355	1	Influenza	Influenza	NNP
cord-356188-rwf78stz	355	2	A	a	DT
cord-356188-rwf78stz	355	3	virus	virus	NN
cord-356188-rwf78stz	355	4	lacking	lack	VBG
cord-356188-rwf78stz	356	1	the	the	DT
cord-356188-rwf78stz	356	2	NS1	NS1	NNP
cord-356188-rwf78stz	356	3	gene	gene	NN
cord-356188-rwf78stz	356	4	replicates	replicate	NNS
cord-356188-rwf78stz	356	5	in	in	IN
cord-356188-rwf78stz	356	6	interferon	interferon	NN
cord-356188-rwf78stz	356	7	-	-	HYPH
cord-356188-rwf78stz	356	8	deficient	deficient	JJ
cord-356188-rwf78stz	356	9	systems	system	NNS
cord-356188-rwf78stz	356	10	Species	species	NN
cord-356188-rwf78stz	356	11	-	-	HYPH
cord-356188-rwf78stz	356	12	specific	specific	JJ
cord-356188-rwf78stz	356	13	antagonism	antagonism	NN
cord-356188-rwf78stz	356	14	of	of	IN
cord-356188-rwf78stz	356	15	host	host	NN
cord-356188-rwf78stz	356	16	ISGylation	ISGylation	NNP
cord-356188-rwf78stz	356	17	by	by	IN
cord-356188-rwf78stz	356	18	the	the	DT
cord-356188-rwf78stz	356	19	influenza	influenza	NN
cord-356188-rwf78stz	356	20	B	B	NNP
cord-356188-rwf78stz	356	21	virus	virus	NN
cord-356188-rwf78stz	356	22	NS1	ns1	NN
cord-356188-rwf78stz	356	23	protein	protein	NN
cord-356188-rwf78stz	356	24	Monocyte	Monocyte	NNP
cord-356188-rwf78stz	356	25	-	-	HYPH
cord-356188-rwf78stz	356	26	mediated	mediate	VBN
cord-356188-rwf78stz	356	27	defense	defense	NN
cord-356188-rwf78stz	356	28	against	against	IN
cord-356188-rwf78stz	356	29	microbial	microbial	JJ
cord-356188-rwf78stz	356	30	pathogens	pathogen	NNS
cord-356188-rwf78stz	356	31	Contrasting	contrast	VBG
cord-356188-rwf78stz	356	32	effects	effect	NNS
cord-356188-rwf78stz	356	33	of	of	IN
cord-356188-rwf78stz	356	34	CCR5	CCR5	NNP
cord-356188-rwf78stz	356	35	and	and	CC
cord-356188-rwf78stz	356	36	CCR2	CCR2	NNP
cord-356188-rwf78stz	356	37	deficiency	deficiency	NN
cord-356188-rwf78stz	356	38	in	in	IN
cord-356188-rwf78stz	356	39	the	the	DT
cord-356188-rwf78stz	356	40	pulmonary	pulmonary	JJ
cord-356188-rwf78stz	356	41	inflammatory	inflammatory	JJ
cord-356188-rwf78stz	356	42	response	response	NN
cord-356188-rwf78stz	356	43	to	to	TO
cord-356188-rwf78stz	356	44	influenza	influenza	VB
cord-356188-rwf78stz	356	45	A	a	DT
cord-356188-rwf78stz	356	46	virus	virus	NN
cord-356188-rwf78stz	356	47	Chemokine	chemokine	JJ
cord-356188-rwf78stz	356	48	regulation	regulation	NN
cord-356188-rwf78stz	356	49	of	of	IN
cord-356188-rwf78stz	356	50	the	the	DT
cord-356188-rwf78stz	356	51	inflammatory	inflammatory	JJ
cord-356188-rwf78stz	356	52	response	response	NN
cord-356188-rwf78stz	356	53	to	to	IN
cord-356188-rwf78stz	356	54	a	a	DT
cord-356188-rwf78stz	356	55	low	low	JJ
cord-356188-rwf78stz	356	56	-	-	HYPH
cord-356188-rwf78stz	356	57	dose	dose	NN
cord-356188-rwf78stz	356	58	influenza	influenza	NN
cord-356188-rwf78stz	356	59	infection	infection	NN
cord-356188-rwf78stz	356	60	in	in	IN
cord-356188-rwf78stz	356	61	CCR2Ϫ/Ϫ	CCR2Ϫ/Ϫ	NNP
cord-356188-rwf78stz	356	62	mice	mouse	NNS
cord-356188-rwf78stz	356	63	TNF	TNF	NNP
cord-356188-rwf78stz	356	64	/	/	SYM
cord-356188-rwf78stz	356	65	iNOS	inos	NN
cord-356188-rwf78stz	356	66	-	-	HYPH
cord-356188-rwf78stz	356	67	producing	produce	VBG
cord-356188-rwf78stz	356	68	dendritic	dendritic	JJ
cord-356188-rwf78stz	356	69	cells	cell	NNS
cord-356188-rwf78stz	356	70	are	be	VBP
cord-356188-rwf78stz	356	71	the	the	DT
cord-356188-rwf78stz	356	72	necessary	necessary	JJ
cord-356188-rwf78stz	356	73	evil	evil	NN
cord-356188-rwf78stz	356	74	of	of	IN
cord-356188-rwf78stz	356	75	lethal	lethal	JJ
cord-356188-rwf78stz	356	76	influenza	influenza	NN
cord-356188-rwf78stz	356	77	virus	virus	NN
cord-356188-rwf78stz	356	78	infection	infection	NN
cord-356188-rwf78stz	356	79	Fatal	fatal	JJ
cord-356188-rwf78stz	356	80	outcome	outcome	NN
cord-356188-rwf78stz	356	81	of	of	IN
cord-356188-rwf78stz	356	82	pandemic	pandemic	NN
cord-356188-rwf78stz	356	83	H1N1	H1N1	NNP
cord-356188-rwf78stz	356	84	2009	2009	CD
cord-356188-rwf78stz	356	85	influenza	influenza	NN
cord-356188-rwf78stz	356	86	virus	virus	NN
cord-356188-rwf78stz	356	87	infection	infection	NN
cord-356188-rwf78stz	356	88	is	be	VBZ
cord-356188-rwf78stz	356	89	associated	associate	VBN
cord-356188-rwf78stz	356	90	with	with	IN
cord-356188-rwf78stz	356	91	immunopathology	immunopathology	NN
cord-356188-rwf78stz	356	92	and	and	CC
cord-356188-rwf78stz	356	93	impaired	impaired	JJ
cord-356188-rwf78stz	356	94	lung	lung	NN
cord-356188-rwf78stz	356	95	repair	repair	NN
cord-356188-rwf78stz	356	96	,	,	,
cord-356188-rwf78stz	356	97	not	not	RB
cord-356188-rwf78stz	356	98	enhanced	enhance	VBN
cord-356188-rwf78stz	356	99	viral	viral	JJ
cord-356188-rwf78stz	356	100	burden	burden	NN
cord-356188-rwf78stz	356	101	in	in	IN
cord-356188-rwf78stz	356	102	pregnant	pregnant	JJ
cord-356188-rwf78stz	356	103	mice	mouse	NNS
cord-356188-rwf78stz	356	104	Alveolar	alveolar	NN
cord-356188-rwf78stz	356	105	epithelial	epithelial	JJ
cord-356188-rwf78stz	356	106	cells	cell	NNS
cord-356188-rwf78stz	356	107	direct	direct	JJ
cord-356188-rwf78stz	356	108	monocyte	monocyte	NNP
cord-356188-rwf78stz	356	109	transepithelial	transepithelial	JJ
cord-356188-rwf78stz	356	110	migration	migration	NN
cord-356188-rwf78stz	356	111	upon	upon	IN
cord-356188-rwf78stz	356	112	influenza	influenza	NN
cord-356188-rwf78stz	356	113	virus	virus	NN
cord-356188-rwf78stz	356	114	infection	infection	NN
cord-356188-rwf78stz	356	115	:	:	:
cord-356188-rwf78stz	356	116	impact	impact	NN
cord-356188-rwf78stz	356	117	of	of	IN
cord-356188-rwf78stz	356	118	chemokines	chemokine	NNS
cord-356188-rwf78stz	356	119	and	and	CC
cord-356188-rwf78stz	356	120	adhesion	adhesion	NN
cord-356188-rwf78stz	356	121	molecules	molecule	NNS
cord-356188-rwf78stz	357	1	CXCR2	CXCR2	NNP
cord-356188-rwf78stz	357	2	is	be	VBZ
cord-356188-rwf78stz	357	3	required	require	VBN
cord-356188-rwf78stz	357	4	for	for	IN
cord-356188-rwf78stz	357	5	neutrophil	neutrophil	NN
cord-356188-rwf78stz	357	6	recruitment	recruitment	NN
cord-356188-rwf78stz	357	7	to	to	IN
cord-356188-rwf78stz	357	8	the	the	DT
cord-356188-rwf78stz	357	9	lung	lung	NN
cord-356188-rwf78stz	357	10	during	during	IN
cord-356188-rwf78stz	357	11	influenza	influenza	NN
cord-356188-rwf78stz	357	12	virus	virus	NN
cord-356188-rwf78stz	357	13	infection	infection	NN
cord-356188-rwf78stz	357	14	,	,	,
cord-356188-rwf78stz	357	15	but	but	CC
cord-356188-rwf78stz	357	16	is	be	VBZ
cord-356188-rwf78stz	357	17	not	not	RB
cord-356188-rwf78stz	357	18	essential	essential	JJ
cord-356188-rwf78stz	357	19	for	for	IN
cord-356188-rwf78stz	358	1	viral	viral	JJ
cord-356188-rwf78stz	358	2	clearance	clearance	NN
cord-356188-rwf78stz	358	3	Type	type	NN
cord-356188-rwf78stz	358	4	I	-PRON-	PRP
cord-356188-rwf78stz	358	5	interferon	interferon	NN
cord-356188-rwf78stz	358	6	signaling	signal	VBG
cord-356188-rwf78stz	358	7	regulates	regulate	VBZ
cord-356188-rwf78stz	358	8	Ly6C	ly6c	JJ
cord-356188-rwf78stz	358	9	monocytes	monocyte	NNS
cord-356188-rwf78stz	358	10	and	and	CC
cord-356188-rwf78stz	358	11	neutrophils	neutrophil	NNS
cord-356188-rwf78stz	358	12	during	during	IN
cord-356188-rwf78stz	358	13	acute	acute	JJ
cord-356188-rwf78stz	358	14	viral	viral	JJ
cord-356188-rwf78stz	358	15	pneumonia	pneumonia	NN
cord-356188-rwf78stz	358	16	in	in	IN
cord-356188-rwf78stz	358	17	mice	mouse	NNS
cord-356188-rwf78stz	359	1	nate	nate	NNP
cord-356188-rwf78stz	359	2	lymphoid	lymphoid	NNP
cord-356188-rwf78stz	359	3	cells	cell	NNS
cord-356188-rwf78stz	359	4	promote	promote	VBP
cord-356188-rwf78stz	359	5	lung	lung	NN
cord-356188-rwf78stz	359	6	-	-	HYPH
cord-356188-rwf78stz	359	7	tissue	tissue	NN
cord-356188-rwf78stz	359	8	homeostasis	homeostasis	NN
cord-356188-rwf78stz	359	9	after	after	IN
cord-356188-rwf78stz	359	10	infection	infection	NN
cord-356188-rwf78stz	359	11	with	with	IN
cord-356188-rwf78stz	359	12	influenza	influenza	NN
cord-356188-rwf78stz	359	13	virus	virus	NN
cord-356188-rwf78stz	359	14	Influenza	Influenza	NNP
cord-356188-rwf78stz	359	15	A	a	DT
cord-356188-rwf78stz	359	16	virus	virus	NN
cord-356188-rwf78stz	359	17	accelerates	accelerate	VBZ
cord-356188-rwf78stz	359	18	neutrophil	neutrophil	NN
cord-356188-rwf78stz	359	19	apoptosis	apoptosis	NN
cord-356188-rwf78stz	359	20	and	and	CC
cord-356188-rwf78stz	359	21	markedly	markedly	RB
cord-356188-rwf78stz	359	22	potentiates	potentiate	VBZ
cord-356188-rwf78stz	359	23	apoptotic	apoptotic	JJ
cord-356188-rwf78stz	359	24	effects	effect	NNS
cord-356188-rwf78stz	359	25	of	of	IN
cord-356188-rwf78stz	359	26	bacteria	bacteria	NNS
cord-356188-rwf78stz	359	27	Programmed	program	VBD
cord-356188-rwf78stz	359	28	cell	cell	NN
cord-356188-rwf78stz	359	29	death	death	NN
cord-356188-rwf78stz	359	30	(	(	-LRB-
cord-356188-rwf78stz	359	31	apoptosis	apoptosis	NN
cord-356188-rwf78stz	359	32	)	)	-RRB-
cord-356188-rwf78stz	359	33	in	in	IN
cord-356188-rwf78stz	359	34	human	human	JJ
cord-356188-rwf78stz	359	35	monocytes	monocyte	NNS
cord-356188-rwf78stz	359	36	infected	infect	VBN
cord-356188-rwf78stz	359	37	by	by	IN
cord-356188-rwf78stz	359	38	influenza	influenza	NN
cord-356188-rwf78stz	359	39	A	a	NN
cord-356188-rwf78stz	360	1	virus	virus	NN
cord-356188-rwf78stz	360	2	Effect	effect	NN
cord-356188-rwf78stz	360	3	of	of	IN
cord-356188-rwf78stz	360	4	virus	virus	NN
cord-356188-rwf78stz	360	5	infections	infection	NNS
cord-356188-rwf78stz	360	6	on	on	IN
cord-356188-rwf78stz	360	7	polymorph	polymorph	NN
cord-356188-rwf78stz	360	8	function	function	NN
cord-356188-rwf78stz	360	9	in	in	IN
cord-356188-rwf78stz	360	10	children	child	NNS
cord-356188-rwf78stz	360	11	Depressed	depress	VBN
cord-356188-rwf78stz	360	12	monocyte	monocyte	JJ
cord-356188-rwf78stz	360	13	chemotaxis	chemotaxis	NN
cord-356188-rwf78stz	360	14	during	during	IN
cord-356188-rwf78stz	360	15	acute	acute	JJ
cord-356188-rwf78stz	360	16	influenza	influenza	NN
cord-356188-rwf78stz	360	17	infection	infection	NN
cord-356188-rwf78stz	360	18	Effects	effect	NNS
cord-356188-rwf78stz	360	19	of	of	IN
cord-356188-rwf78stz	360	20	infection	infection	NN
cord-356188-rwf78stz	360	21	with	with	IN
cord-356188-rwf78stz	360	22	influenza	influenza	NN
cord-356188-rwf78stz	360	23	virus	virus	NN
cord-356188-rwf78stz	360	24	on	on	IN
cord-356188-rwf78stz	360	25	the	the	DT
cord-356188-rwf78stz	360	26	function	function	NN
cord-356188-rwf78stz	360	27	of	of	IN
cord-356188-rwf78stz	360	28	polymorphonuclear	polymorphonuclear	JJ
cord-356188-rwf78stz	360	29	leukocytes	leukocyte	NNS
cord-356188-rwf78stz	360	30	Differences	difference	NNS
cord-356188-rwf78stz	360	31	in	in	IN
cord-356188-rwf78stz	360	32	serum	serum	NN
cord-356188-rwf78stz	360	33	cytokine	cytokine	NN
cord-356188-rwf78stz	360	34	levels	level	NNS
cord-356188-rwf78stz	360	35	between	between	IN
cord-356188-rwf78stz	360	36	influenza	influenza	NN
cord-356188-rwf78stz	360	37	virus	virus	NN
cord-356188-rwf78stz	360	38	A	a	NN
cord-356188-rwf78stz	360	39	and	and	CC
cord-356188-rwf78stz	360	40	B	b	NN
cord-356188-rwf78stz	360	41	infections	infection	NNS
cord-356188-rwf78stz	360	42	in	in	IN
cord-356188-rwf78stz	360	43	children	child	NNS
cord-356188-rwf78stz	360	44	Cytokine	cytokine	NN
cord-356188-rwf78stz	360	45	induction	induction	NN
cord-356188-rwf78stz	360	46	in	in	IN
cord-356188-rwf78stz	360	47	human	human	JJ
cord-356188-rwf78stz	360	48	cord	cord	NN
cord-356188-rwf78stz	360	49	blood	blood	NN
cord-356188-rwf78stz	360	50	lymphocytes	lymphocyte	NNS
cord-356188-rwf78stz	360	51	after	after	IN
cord-356188-rwf78stz	360	52	pulsing	pulse	VBG
cord-356188-rwf78stz	360	53	with	with	IN
cord-356188-rwf78stz	360	54	UV	uv	NN
cord-356188-rwf78stz	360	55	-	-	HYPH
cord-356188-rwf78stz	360	56	inactivated	inactivate	VBN
cord-356188-rwf78stz	360	57	influenza	influenza	NN
cord-356188-rwf78stz	360	58	viruses	viruse	VBZ
cord-356188-rwf78stz	360	59	Experiments	experiment	NNS
cord-356188-rwf78stz	360	60	to	to	TO
cord-356188-rwf78stz	360	61	determine	determine	VB
cord-356188-rwf78stz	360	62	mode	mode	NN
cord-356188-rwf78stz	360	63	of	of	IN
cord-356188-rwf78stz	360	64	spread	spread	NN
cord-356188-rwf78stz	360	65	of	of	IN
cord-356188-rwf78stz	360	66	influenza	influenza	NN
cord-356188-rwf78stz	360	67	Clinical	clinical	JJ
cord-356188-rwf78stz	360	68	and	and	CC
cord-356188-rwf78stz	360	69	immunological	immunological	JJ
cord-356188-rwf78stz	360	70	characteristics	characteristic	NNS
cord-356188-rwf78stz	360	71	of	of	IN
cord-356188-rwf78stz	360	72	patients	patient	NNS
cord-356188-rwf78stz	360	73	with	with	IN
cord-356188-rwf78stz	360	74	2009	2009	CD
cord-356188-rwf78stz	360	75	pandemic	pandemic	NN
cord-356188-rwf78stz	361	1	influenza	influenza	NNP
cord-356188-rwf78stz	361	2	A	A	NNP
cord-356188-rwf78stz	361	3	(	(	-LRB-
cord-356188-rwf78stz	361	4	H1N1	H1N1	NNP
cord-356188-rwf78stz	361	5	)	)	-RRB-
cord-356188-rwf78stz	361	6	virus	virus	NN
cord-356188-rwf78stz	361	7	infection	infection	NN
cord-356188-rwf78stz	361	8	after	after	IN
cord-356188-rwf78stz	361	9	vaccination	vaccination	NN
cord-356188-rwf78stz	362	1	The	the	DT
cord-356188-rwf78stz	362	2	role	role	NN
cord-356188-rwf78stz	362	3	of	of	IN
cord-356188-rwf78stz	362	4	the	the	DT
cord-356188-rwf78stz	362	5	antibody	antibody	NN
cord-356188-rwf78stz	362	6	response	response	NN
cord-356188-rwf78stz	362	7	in	in	IN
cord-356188-rwf78stz	362	8	influenza	influenza	NN
cord-356188-rwf78stz	362	9	virus	virus	NN
cord-356188-rwf78stz	362	10	infection	infection	NN
cord-356188-rwf78stz	362	11	Antigenic	antigenic	JJ
cord-356188-rwf78stz	362	12	fingerprinting	fingerprinting	NN
cord-356188-rwf78stz	362	13	of	of	IN
cord-356188-rwf78stz	362	14	H5N1	H5N1	NNP
cord-356188-rwf78stz	362	15	avian	avian	JJ
cord-356188-rwf78stz	362	16	influenza	influenza	NN
cord-356188-rwf78stz	362	17	using	use	VBG
cord-356188-rwf78stz	362	18	convalescent	convalescent	JJ
cord-356188-rwf78stz	362	19	sera	sera	NNP
cord-356188-rwf78stz	362	20	and	and	CC
cord-356188-rwf78stz	362	21	monoclonal	monoclonal	JJ
cord-356188-rwf78stz	362	22	antibodies	antibody	NNS
cord-356188-rwf78stz	362	23	reveals	reveal	VBZ
cord-356188-rwf78stz	362	24	potential	potential	JJ
cord-356188-rwf78stz	362	25	vaccine	vaccine	NN
cord-356188-rwf78stz	362	26	and	and	CC
cord-356188-rwf78stz	362	27	diagnostic	diagnostic	JJ
cord-356188-rwf78stz	362	28	targets	target	NNS
cord-356188-rwf78stz	362	29	Pre	pre	VB
cord-356188-rwf78stz	362	30	-	-	JJ
cord-356188-rwf78stz	362	31	existing	existing	JJ
cord-356188-rwf78stz	362	32	immunity	immunity	NN
cord-356188-rwf78stz	362	33	against	against	IN
cord-356188-rwf78stz	362	34	swine	swine	NN
cord-356188-rwf78stz	362	35	-	-	HYPH
cord-356188-rwf78stz	362	36	origin	origin	NN
cord-356188-rwf78stz	362	37	H1N1	H1N1	NNP
cord-356188-rwf78stz	362	38	influenza	influenza	NN
cord-356188-rwf78stz	362	39	viruses	virus	NNS
cord-356188-rwf78stz	362	40	in	in	IN
cord-356188-rwf78stz	362	41	the	the	DT
cord-356188-rwf78stz	362	42	general	general	JJ
cord-356188-rwf78stz	362	43	human	human	JJ
cord-356188-rwf78stz	362	44	population	population	NNP
cord-356188-rwf78stz	362	45	Human	Human	NNP
cord-356188-rwf78stz	362	46	dendritic	dendritic	JJ
cord-356188-rwf78stz	362	47	cell	cell	NN
cord-356188-rwf78stz	362	48	deficiency	deficiency	NN
cord-356188-rwf78stz	362	49	:	:	:
cord-356188-rwf78stz	362	50	the	the	DT
cord-356188-rwf78stz	362	51	missing	miss	VBG
cord-356188-rwf78stz	362	52	ID	ID	NNP
cord-356188-rwf78stz	362	53	?	?	.
cord-356188-rwf78stz	363	1	Influenza	influenza	NN
cord-356188-rwf78stz	363	2	virus	virus	NN
cord-356188-rwf78stz	363	3	-	-	HYPH
cord-356188-rwf78stz	363	4	infected	infect	VBN
cord-356188-rwf78stz	363	5	dendritic	dendritic	JJ
cord-356188-rwf78stz	363	6	cells	cell	NNS
cord-356188-rwf78stz	363	7	stimulate	stimulate	VBP
cord-356188-rwf78stz	363	8	strong	strong	JJ
cord-356188-rwf78stz	363	9	proliferative	proliferative	JJ
cord-356188-rwf78stz	363	10	and	and	CC
cord-356188-rwf78stz	363	11	cytolytic	cytolytic	JJ
cord-356188-rwf78stz	363	12	responses	response	NNS
cord-356188-rwf78stz	363	13	from	from	IN
cord-356188-rwf78stz	363	14	human	human	JJ
cord-356188-rwf78stz	363	15	CD8ϩ	CD8ϩ	NNP
cord-356188-rwf78stz	363	16	T	T	NNP
cord-356188-rwf78stz	363	17	cells	cell	NNS
cord-356188-rwf78stz	364	1	Plasmacytoid	Plasmacytoid	NNP
cord-356188-rwf78stz	364	2	dendritic	dendritic	JJ
cord-356188-rwf78stz	364	3	cells	cell	NNS
cord-356188-rwf78stz	364	4	activated	activate	VBN
cord-356188-rwf78stz	364	5	by	by	IN
cord-356188-rwf78stz	364	6	influenza	influenza	NN
cord-356188-rwf78stz	364	7	virus	virus	NN
cord-356188-rwf78stz	364	8	and	and	CC
cord-356188-rwf78stz	365	1	CD40L	CD40L	NNP
cord-356188-rwf78stz	365	2	drive	drive	VB
cord-356188-rwf78stz	365	3	a	a	DT
cord-356188-rwf78stz	365	4	potent	potent	JJ
cord-356188-rwf78stz	365	5	TH1	th1	NN
cord-356188-rwf78stz	365	6	polarization	polarization	NN
cord-356188-rwf78stz	365	7	Influenza	Influenza	NNP
cord-356188-rwf78stz	365	8	A	a	NN
cord-356188-rwf78stz	366	1	virus	virus	NN
cord-356188-rwf78stz	366	2	-	-	HYPH
cord-356188-rwf78stz	366	3	induced	induce	VBN
cord-356188-rwf78stz	366	4	IFN-	IFN-	NNP
cord-356188-rwf78stz	366	5	␣	␣	NNP
cord-356188-rwf78stz	366	6	/	/	SYM
cord-356188-rwf78stz	366	7	␤	␤	NNP
cord-356188-rwf78stz	366	8	and	and	CC
cord-356188-rwf78stz	366	9	IL-18	IL-18	NNP
cord-356188-rwf78stz	366	10	synergistically	synergistically	RB
cord-356188-rwf78stz	366	11	enhance	enhance	VB
cord-356188-rwf78stz	366	12	IFN-	IFN-	NNP
cord-356188-rwf78stz	366	13	␥	␥	CD
cord-356188-rwf78stz	366	14	gene	gene	NN
cord-356188-rwf78stz	366	15	expression	expression	NN
cord-356188-rwf78stz	366	16	in	in	IN
cord-356188-rwf78stz	366	17	human	human	JJ
cord-356188-rwf78stz	366	18	T	t	NN
cord-356188-rwf78stz	366	19	cells	cell	NNS
cord-356188-rwf78stz	367	1	Selective	selective	JJ
cord-356188-rwf78stz	367	2	accumulation	accumulation	NN
cord-356188-rwf78stz	367	3	of	of	IN
cord-356188-rwf78stz	367	4	differentiated	differentiated	JJ
cord-356188-rwf78stz	367	5	CD8ϩ	CD8ϩ	NNP
cord-356188-rwf78stz	367	6	T	T	NNP
cord-356188-rwf78stz	367	7	cells	cell	NNS
cord-356188-rwf78stz	367	8	specific	specific	JJ
cord-356188-rwf78stz	367	9	for	for	IN
cord-356188-rwf78stz	367	10	respiratory	respiratory	JJ
cord-356188-rwf78stz	367	11	viruses	virus	NNS
cord-356188-rwf78stz	367	12	in	in	IN
cord-356188-rwf78stz	367	13	the	the	DT
cord-356188-rwf78stz	367	14	human	human	JJ
cord-356188-rwf78stz	367	15	lung	lung	NN
cord-356188-rwf78stz	367	16	CD8	CD8	NNP
cord-356188-rwf78stz	367	17	T	T	NNP
cord-356188-rwf78stz	367	18	cells	cell	NNS
cord-356188-rwf78stz	367	19	with	with	IN
cord-356188-rwf78stz	367	20	an	an	DT
cord-356188-rwf78stz	367	21	intraepithelial	intraepithelial	JJ
cord-356188-rwf78stz	367	22	phenotype	phenotype	NN
cord-356188-rwf78stz	367	23	upregulate	upregulate	VB
cord-356188-rwf78stz	367	24	cytotoxic	cytotoxic	JJ
cord-356188-rwf78stz	367	25	function	function	NN
cord-356188-rwf78stz	367	26	upon	upon	IN
cord-356188-rwf78stz	367	27	influenza	influenza	NN
cord-356188-rwf78stz	367	28	infection	infection	NN
cord-356188-rwf78stz	367	29	in	in	IN
cord-356188-rwf78stz	367	30	human	human	JJ
cord-356188-rwf78stz	367	31	lung	lung	NN
cord-356188-rwf78stz	367	32	Characterization	characterization	NN
cord-356188-rwf78stz	367	33	of	of	IN
cord-356188-rwf78stz	367	34	the	the	DT
cord-356188-rwf78stz	367	35	human	human	JJ
cord-356188-rwf78stz	367	36	CD8ϩ	CD8ϩ	NNP
cord-356188-rwf78stz	367	37	T	T	NNP
cord-356188-rwf78stz	367	38	cell	cell	NN
cord-356188-rwf78stz	367	39	response	response	NN
cord-356188-rwf78stz	367	40	following	follow	VBG
cord-356188-rwf78stz	367	41	infection	infection	NN
cord-356188-rwf78stz	367	42	with	with	IN
cord-356188-rwf78stz	367	43	2009	2009	CD
cord-356188-rwf78stz	367	44	pandemic	pandemic	NN
cord-356188-rwf78stz	367	45	influenza	influenza	NN
cord-356188-rwf78stz	367	46	H1N1	H1N1	NNP
cord-356188-rwf78stz	367	47	virus	virus	NN
cord-356188-rwf78stz	367	48	Long	long	JJ
cord-356188-rwf78stz	367	49	term	term	NN
cord-356188-rwf78stz	367	50	immune	immune	JJ
cord-356188-rwf78stz	367	51	responses	response	NNS
cord-356188-rwf78stz	367	52	to	to	IN
cord-356188-rwf78stz	367	53	pandemic	pandemic	NN
cord-356188-rwf78stz	367	54	influenza	influenza	NN
cord-356188-rwf78stz	367	55	A	A	NNP
cord-356188-rwf78stz	367	56	/	/	SYM
cord-356188-rwf78stz	367	57	H1N1	H1N1	NNP
cord-356188-rwf78stz	367	58	infection	infection	NN
cord-356188-rwf78stz	367	59	in	in	IN
cord-356188-rwf78stz	367	60	solid	solid	JJ
cord-356188-rwf78stz	367	61	organ	organ	NN
cord-356188-rwf78stz	367	62	transplant	transplant	NN
cord-356188-rwf78stz	367	63	recipients	recipient	NNS
cord-356188-rwf78stz	367	64	CD8ϩ	CD8ϩ	NNP
cord-356188-rwf78stz	367	65	T	t	NN
cord-356188-rwf78stz	367	66	cell	cell	NN
cord-356188-rwf78stz	367	67	immunity	immunity	NN
cord-356188-rwf78stz	367	68	to	to	IN
cord-356188-rwf78stz	367	69	2009	2009	CD
cord-356188-rwf78stz	367	70	pandemic	pandemic	NN
cord-356188-rwf78stz	367	71	and	and	CC
cord-356188-rwf78stz	367	72	seasonal	seasonal	JJ
cord-356188-rwf78stz	367	73	H1N1	H1N1	NNP
cord-356188-rwf78stz	367	74	influenza	influenza	NN
cord-356188-rwf78stz	367	75	viruses	viruse	VBZ
cord-356188-rwf78stz	367	76	Cytotoxic	Cytotoxic	NNP
cord-356188-rwf78stz	367	77	T	T	NNP
cord-356188-rwf78stz	367	78	lymphocytes	lymphocyte	NNS
cord-356188-rwf78stz	367	79	established	establish	VBN
cord-356188-rwf78stz	367	80	by	by	IN
cord-356188-rwf78stz	367	81	seasonal	seasonal	JJ
cord-356188-rwf78stz	367	82	human	human	JJ
cord-356188-rwf78stz	367	83	influenza	influenza	NN
cord-356188-rwf78stz	367	84	cross	cross	NN
cord-356188-rwf78stz	367	85	-	-	NN
cord-356188-rwf78stz	367	86	react	react	VB
cord-356188-rwf78stz	367	87	against	against	IN
cord-356188-rwf78stz	367	88	2009	2009	CD
cord-356188-rwf78stz	367	89	pandemic	pandemic	NN
cord-356188-rwf78stz	367	90	H1N1	H1N1	NNP
cord-356188-rwf78stz	367	91	influenza	influenza	NN
cord-356188-rwf78stz	367	92	virus	virus	NN
cord-356188-rwf78stz	367	93	Crossreactive	Crossreactive	NNP
cord-356188-rwf78stz	367	94	CD8ϩ	CD8ϩ	NNP
cord-356188-rwf78stz	367	95	T	T	NNP
cord-356188-rwf78stz	367	96	-	-	HYPH
cord-356188-rwf78stz	367	97	cell	cell	NN
cord-356188-rwf78stz	367	98	immunity	immunity	NN
cord-356188-rwf78stz	367	99	between	between	IN
cord-356188-rwf78stz	367	100	the	the	DT
cord-356188-rwf78stz	367	101	pandemic	pandemic	NN
cord-356188-rwf78stz	367	102	H1N1	H1N1	NNP
cord-356188-rwf78stz	367	103	-	-	HYPH
cord-356188-rwf78stz	367	104	2009	2009	CD
cord-356188-rwf78stz	367	105	and	and	CC
cord-356188-rwf78stz	368	1	H1N1	H1N1	NNP
cord-356188-rwf78stz	368	2	-	-	HYPH
cord-356188-rwf78stz	368	3	1918	1918	CD
cord-356188-rwf78stz	368	4	influenza	influenza	NN
cord-356188-rwf78stz	368	5	A	a	DT
cord-356188-rwf78stz	368	6	viruses	virus	NNS
cord-356188-rwf78stz	369	1	␥	␥	NNP
cord-356188-rwf78stz	369	2	␦	␦	NN
cord-356188-rwf78stz	369	3	T	t	NN
cord-356188-rwf78stz	369	4	cell	cell	NN
cord-356188-rwf78stz	369	5	effector	effector	NN
cord-356188-rwf78stz	369	6	functions	function	NNS
cord-356188-rwf78stz	369	7	:	:	:
cord-356188-rwf78stz	369	8	a	a	DT
cord-356188-rwf78stz	369	9	blend	blend	NN
cord-356188-rwf78stz	369	10	of	of	IN
cord-356188-rwf78stz	369	11	innate	innate	JJ
cord-356188-rwf78stz	369	12	programming	programming	NN
cord-356188-rwf78stz	369	13	and	and	CC
cord-356188-rwf78stz	369	14	acquired	acquire	VBD
cord-356188-rwf78stz	369	15	plasticity	plasticity	NN
cord-356188-rwf78stz	369	16	Phosphoantigen	Phosphoantigen	NNP
cord-356188-rwf78stz	369	17	-	-	HYPH
cord-356188-rwf78stz	369	18	expanded	expand	VBN
cord-356188-rwf78stz	369	19	human	human	NN
cord-356188-rwf78stz	369	20	␥	␥	CD
cord-356188-rwf78stz	369	21	␦	␦	NN
cord-356188-rwf78stz	369	22	T	t	NN
cord-356188-rwf78stz	369	23	cells	cell	NNS
cord-356188-rwf78stz	369	24	display	display	VBP
cord-356188-rwf78stz	369	25	potent	potent	JJ
cord-356188-rwf78stz	369	26	cytotoxicity	cytotoxicity	NN
cord-356188-rwf78stz	369	27	against	against	IN
cord-356188-rwf78stz	369	28	monocyte	monocyte	NNP
cord-356188-rwf78stz	369	29	-	-	HYPH
cord-356188-rwf78stz	369	30	derived	derive	VBN
cord-356188-rwf78stz	369	31	macrophages	macrophage	NNS
cord-356188-rwf78stz	369	32	infected	infect	VBN
cord-356188-rwf78stz	369	33	with	with	IN
cord-356188-rwf78stz	369	34	human	human	JJ
cord-356188-rwf78stz	369	35	and	and	CC
cord-356188-rwf78stz	369	36	avian	avian	JJ
cord-356188-rwf78stz	369	37	influenza	influenza	NN
cord-356188-rwf78stz	369	38	viruses	virus	NNS
cord-356188-rwf78stz	370	1	Type	type	NN
cord-356188-rwf78stz	370	2	1	1	CD
cord-356188-rwf78stz	370	3	responses	response	NNS
cord-356188-rwf78stz	370	4	of	of	IN
cord-356188-rwf78stz	370	5	human	human	NN
cord-356188-rwf78stz	370	6	V	v	NN
cord-356188-rwf78stz	370	7	␥	␥	NNP
cord-356188-rwf78stz	370	8	9V	9v	JJ
cord-356188-rwf78stz	370	9	␦	␦	NN
cord-356188-rwf78stz	370	10	2	2	CD
cord-356188-rwf78stz	370	11	T	t	NN
cord-356188-rwf78stz	370	12	cells	cell	NNS
cord-356188-rwf78stz	370	13	to	to	IN
cord-356188-rwf78stz	370	14	influenza	influenza	VB
cord-356188-rwf78stz	370	15	A	a	DT
cord-356188-rwf78stz	370	16	viruses	virus	NNS
cord-356188-rwf78stz	371	1	Age	age	NN
cord-356188-rwf78stz	371	2	at	at	IN
cord-356188-rwf78stz	371	3	first	first	JJ
cord-356188-rwf78stz	371	4	viral	viral	JJ
cord-356188-rwf78stz	371	5	infection	infection	NN
cord-356188-rwf78stz	371	6	determines	determine	VBZ
cord-356188-rwf78stz	371	7	the	the	DT
cord-356188-rwf78stz	371	8	pattern	pattern	NN
cord-356188-rwf78stz	371	9	of	of	IN
cord-356188-rwf78stz	371	10	T	T	NNP
cord-356188-rwf78stz	371	11	cell	cell	NN
cord-356188-rwf78stz	371	12	-	-	HYPH
cord-356188-rwf78stz	371	13	mediated	mediate	VBN
cord-356188-rwf78stz	371	14	disease	disease	NN
cord-356188-rwf78stz	371	15	during	during	IN
cord-356188-rwf78stz	371	16	reinfection	reinfection	NN
cord-356188-rwf78stz	371	17	in	in	IN
cord-356188-rwf78stz	371	18	adulthood	adulthood	NN
cord-356188-rwf78stz	372	1	The	the	DT
cord-356188-rwf78stz	372	2	enhancement	enhancement	NN
cord-356188-rwf78stz	372	3	or	or	CC
cord-356188-rwf78stz	372	4	prevention	prevention	NN
cord-356188-rwf78stz	372	5	of	of	IN
cord-356188-rwf78stz	372	6	airway	airway	NNP
cord-356188-rwf78stz	372	7	hyperresponsiveness	hyperresponsiveness	NNP
cord-356188-rwf78stz	372	8	during	during	IN
cord-356188-rwf78stz	372	9	reinfection	reinfection	NN
cord-356188-rwf78stz	372	10	with	with	IN
cord-356188-rwf78stz	372	11	respiratory	respiratory	JJ
cord-356188-rwf78stz	372	12	syncytial	syncytial	JJ
cord-356188-rwf78stz	372	13	virus	virus	NN
cord-356188-rwf78stz	372	14	is	be	VBZ
cord-356188-rwf78stz	372	15	critically	critically	RB
cord-356188-rwf78stz	372	16	dependent	dependent	JJ
cord-356188-rwf78stz	372	17	on	on	IN
cord-356188-rwf78stz	372	18	the	the	DT
cord-356188-rwf78stz	372	19	age	age	NN
cord-356188-rwf78stz	372	20	at	at	IN
cord-356188-rwf78stz	372	21	first	first	JJ
cord-356188-rwf78stz	372	22	infection	infection	NN
cord-356188-rwf78stz	372	23	and	and	CC
cord-356188-rwf78stz	372	24	IL-13	IL-13	NNP
cord-356188-rwf78stz	372	25	production	production	NN
cord-356188-rwf78stz	372	26	Exposure	exposure	NN
cord-356188-rwf78stz	372	27	of	of	IN
cord-356188-rwf78stz	372	28	neonates	neonate	NNS
cord-356188-rwf78stz	372	29	to	to	IN
cord-356188-rwf78stz	372	30	respiratory	respiratory	JJ
cord-356188-rwf78stz	372	31	syncytial	syncytial	JJ
cord-356188-rwf78stz	372	32	virus	virus	NN
cord-356188-rwf78stz	372	33	is	be	VBZ
cord-356188-rwf78stz	372	34	critical	critical	JJ
cord-356188-rwf78stz	372	35	in	in	IN
cord-356188-rwf78stz	372	36	determining	determine	VBG
cord-356188-rwf78stz	372	37	subsequent	subsequent	JJ
cord-356188-rwf78stz	372	38	airway	airway	NN
cord-356188-rwf78stz	372	39	response	response	NN
cord-356188-rwf78stz	372	40	in	in	IN
cord-356188-rwf78stz	372	41	adults	adult	NNS
cord-356188-rwf78stz	372	42	Inchoate	inchoate	JJ
cord-356188-rwf78stz	372	43	CD8ϩ	CD8ϩ	NNP
cord-356188-rwf78stz	372	44	T	t	NN
cord-356188-rwf78stz	372	45	cell	cell	NN
cord-356188-rwf78stz	372	46	responses	response	NNS
cord-356188-rwf78stz	372	47	in	in	IN
cord-356188-rwf78stz	372	48	neonatal	neonatal	JJ
cord-356188-rwf78stz	372	49	mice	mice	NN
cord-356188-rwf78stz	372	50	permit	permit	VBP
cord-356188-rwf78stz	372	51	influenza	influenza	NN
cord-356188-rwf78stz	372	52	-	-	HYPH
cord-356188-rwf78stz	372	53	induced	induce	VBN
cord-356188-rwf78stz	372	54	persistent	persistent	JJ
cord-356188-rwf78stz	372	55	pulmonary	pulmonary	JJ
cord-356188-rwf78stz	372	56	dysfunction	dysfunction	NN
cord-356188-rwf78stz	372	57	Severe	severe	JJ
cord-356188-rwf78stz	372	58	acute	acute	JJ
cord-356188-rwf78stz	372	59	respiratory	respiratory	JJ
cord-356188-rwf78stz	372	60	syndrome	syndrome	NN
cord-356188-rwf78stz	372	61	complicated	complicate	VBN
cord-356188-rwf78stz	372	62	by	by	IN
cord-356188-rwf78stz	372	63	spontaneous	spontaneous	JJ
cord-356188-rwf78stz	372	64	pneumothorax	pneumothorax	NN
cord-356188-rwf78stz	373	1	A	a	DT
cord-356188-rwf78stz	373	2	major	major	JJ
cord-356188-rwf78stz	373	3	outbreak	outbreak	NN
cord-356188-rwf78stz	373	4	of	of	IN
cord-356188-rwf78stz	373	5	severe	severe	JJ
cord-356188-rwf78stz	373	6	acute	acute	JJ
cord-356188-rwf78stz	373	7	respiratory	respiratory	JJ
cord-356188-rwf78stz	373	8	syndrome	syndrome	NN
cord-356188-rwf78stz	373	9	in	in	IN
cord-356188-rwf78stz	373	10	Hong	Hong	NNP
cord-356188-rwf78stz	373	11	Kong	Kong	NNP
cord-356188-rwf78stz	374	1	The	the	DT
cord-356188-rwf78stz	374	2	magnitude	magnitude	NN
cord-356188-rwf78stz	374	3	and	and	CC
cord-356188-rwf78stz	374	4	specificity	specificity	NN
cord-356188-rwf78stz	374	5	of	of	IN
cord-356188-rwf78stz	374	6	influenza	influenza	NN
cord-356188-rwf78stz	374	7	A	a	DT
cord-356188-rwf78stz	374	8	virus	virus	NN
cord-356188-rwf78stz	374	9	-	-	HYPH
cord-356188-rwf78stz	374	10	specific	specific	JJ
cord-356188-rwf78stz	374	11	cytotoxic	cytotoxic	JJ
cord-356188-rwf78stz	374	12	T	t	NN
cord-356188-rwf78stz	374	13	-	-	HYPH
cord-356188-rwf78stz	374	14	lymphocyte	lymphocyte	NN
cord-356188-rwf78stz	374	15	responses	response	NNS
cord-356188-rwf78stz	374	16	in	in	IN
cord-356188-rwf78stz	374	17	humans	human	NNS
cord-356188-rwf78stz	374	18	is	be	VBZ
cord-356188-rwf78stz	374	19	related	relate	VBN
cord-356188-rwf78stz	374	20	to	to	IN
cord-356188-rwf78stz	374	21	HLA	HLA	NNP
cord-356188-rwf78stz	374	22	-	-	HYPH
cord-356188-rwf78stz	374	23	A	A	NNP
cord-356188-rwf78stz	374	24	and	and	CC
cord-356188-rwf78stz	374	25	-B	-B	NFP
cord-356188-rwf78stz	374	26	phenotype	phenotype	NN
cord-356188-rwf78stz	375	1	The	the	DT
cord-356188-rwf78stz	375	2	minimum	minimum	JJ
cord-356188-rwf78stz	375	3	peptide	peptide	NN
cord-356188-rwf78stz	375	4	epitope	epitope	NN
cord-356188-rwf78stz	375	5	from	from	IN
cord-356188-rwf78stz	375	6	the	the	DT
cord-356188-rwf78stz	375	7	influenza	influenza	NN
cord-356188-rwf78stz	375	8	virus	virus	NN
cord-356188-rwf78stz	375	9	matrix	matrix	NN
cord-356188-rwf78stz	375	10	protein	protein	NN
cord-356188-rwf78stz	375	11	.	.	.
cord-356188-rwf78stz	376	1	Extra	extra	JJ
cord-356188-rwf78stz	376	2	and	and	CC
cord-356188-rwf78stz	376	3	intracellular	intracellular	JJ
cord-356188-rwf78stz	376	4	loading	loading	NN
cord-356188-rwf78stz	376	5	of	of	IN
cord-356188-rwf78stz	376	6	HLA	HLA	NNP
cord-356188-rwf78stz	376	7	-	-	HYPH
cord-356188-rwf78stz	376	8	A2	A2	NNP
cord-356188-rwf78stz	376	9	Systematic	systematic	JJ
cord-356188-rwf78stz	376	10	identification	identification	NN
cord-356188-rwf78stz	376	11	of	of	IN
cord-356188-rwf78stz	376	12	immunodominant	immunodominant	JJ
cord-356188-rwf78stz	376	13	CD8ϩ	CD8ϩ	NNP
cord-356188-rwf78stz	376	14	T	T	NNP
cord-356188-rwf78stz	376	15	-	-	HYPH
cord-356188-rwf78stz	376	16	cell	cell	NN
cord-356188-rwf78stz	376	17	responses	response	NNS
cord-356188-rwf78stz	376	18	to	to	TO
cord-356188-rwf78stz	376	19	influenza	influenza	VB
cord-356188-rwf78stz	376	20	A	a	DT
cord-356188-rwf78stz	376	21	virus	virus	NN
cord-356188-rwf78stz	376	22	in	in	IN
cord-356188-rwf78stz	376	23	HLA	HLA	NNP
cord-356188-rwf78stz	376	24	-	-	HYPH
cord-356188-rwf78stz	376	25	A2	A2	NNP
cord-356188-rwf78stz	376	26	individuals	individual	NNS
cord-356188-rwf78stz	377	1	Human	Human	NNP
cord-356188-rwf78stz	377	2	HLA	HLA	NNP
cord-356188-rwf78stz	377	3	-	-	HYPH
cord-356188-rwf78stz	377	4	A0201-restricted	a0201-restricte	VBN
cord-356188-rwf78stz	377	5	cytotoxic	cytotoxic	JJ
cord-356188-rwf78stz	377	6	T	t	NN
cord-356188-rwf78stz	377	7	lymphocyte	lymphocyte	NN
cord-356188-rwf78stz	377	8	recognition	recognition	NN
cord-356188-rwf78stz	377	9	of	of	IN
cord-356188-rwf78stz	377	10	influenza	influenza	NN
cord-356188-rwf78stz	377	11	A	A	NNP
cord-356188-rwf78stz	377	12	is	be	VBZ
cord-356188-rwf78stz	377	13	dominated	dominate	VBN
cord-356188-rwf78stz	377	14	by	by	IN
cord-356188-rwf78stz	377	15	T	T	NNP
cord-356188-rwf78stz	377	16	cells	cell	NNS
cord-356188-rwf78stz	377	17	bearing	bear	VBG
cord-356188-rwf78stz	377	18	the	the	DT
cord-356188-rwf78stz	377	19	V	v	NN
cord-356188-rwf78stz	377	20	beta	beta	NN
cord-356188-rwf78stz	377	21	17	17	CD
cord-356188-rwf78stz	377	22	gene	gene	NN
cord-356188-rwf78stz	377	23	segment	segment	NN
cord-356188-rwf78stz	377	24	Host	host	NN
cord-356188-rwf78stz	377	25	genetic	genetic	JJ
cord-356188-rwf78stz	377	26	variation	variation	NN
cord-356188-rwf78stz	377	27	affects	affect	VBZ
cord-356188-rwf78stz	377	28	resistance	resistance	NN
cord-356188-rwf78stz	377	29	to	to	IN
cord-356188-rwf78stz	377	30	infection	infection	NN
cord-356188-rwf78stz	377	31	with	with	IN
cord-356188-rwf78stz	377	32	a	a	DT
cord-356188-rwf78stz	377	33	highly	highly	RB
cord-356188-rwf78stz	377	34	pathogenic	pathogenic	JJ
cord-356188-rwf78stz	377	35	H5N1	H5N1	NNP
cord-356188-rwf78stz	377	36	influenza	influenza	NN
cord-356188-rwf78stz	377	37	A	a	DT
cord-356188-rwf78stz	377	38	virus	virus	NN
cord-356188-rwf78stz	377	39	in	in	IN
cord-356188-rwf78stz	377	40	mice	mouse	NNS
cord-356188-rwf78stz	377	41	Diabetes	diabetes	NN
cord-356188-rwf78stz	377	42	prevalence	prevalence	NN
cord-356188-rwf78stz	377	43	among	among	IN
cord-356188-rwf78stz	377	44	American	American	NNP
cord-356188-rwf78stz	377	45	Indians	Indians	NNPS
cord-356188-rwf78stz	377	46	and	and	CC
cord-356188-rwf78stz	377	47	Alaska	Alaska	NNP
cord-356188-rwf78stz	377	48	Natives	Natives	NNPS
cord-356188-rwf78stz	377	49	and	and	CC
cord-356188-rwf78stz	377	50	the	the	DT
cord-356188-rwf78stz	377	51	overall	overall	JJ
cord-356188-rwf78stz	377	52	population	population	NN
cord-356188-rwf78stz	377	53	-	-	:
cord-356188-rwf78stz	377	54	United	United	NNP
cord-356188-rwf78stz	377	55	States	States	NNP
cord-356188-rwf78stz	377	56	Preferential	Preferential	NNP
cord-356188-rwf78stz	377	57	HLA	HLA	NNP
cord-356188-rwf78stz	377	58	usage	usage	NN
cord-356188-rwf78stz	377	59	in	in	IN
cord-356188-rwf78stz	377	60	the	the	DT
cord-356188-rwf78stz	377	61	influenza	influenza	NN
cord-356188-rwf78stz	377	62	virus	virus	NN
cord-356188-rwf78stz	377	63	-	-	HYPH
cord-356188-rwf78stz	377	64	specific	specific	JJ
cord-356188-rwf78stz	377	65	CTL	CTL	NNP
cord-356188-rwf78stz	377	66	response	response	NN
cord-356188-rwf78stz	377	67	Systems	Systems	NNPS
cord-356188-rwf78stz	377	68	vaccinology	vaccinology	NN
cord-356188-rwf78stz	377	69	:	:	:
cord-356188-rwf78stz	377	70	learning	learn	VBG
cord-356188-rwf78stz	377	71	to	to	TO
cord-356188-rwf78stz	377	72	compute	compute	VB
cord-356188-rwf78stz	377	73	the	the	DT
cord-356188-rwf78stz	377	74	behavior	behavior	NN
cord-356188-rwf78stz	377	75	of	of	IN
cord-356188-rwf78stz	377	76	vaccine	vaccine	NN
cord-356188-rwf78stz	377	77	induced	induce	VBN
cord-356188-rwf78stz	377	78	immunity	immunity	NN
cord-356188-rwf78stz	377	79	Complement	complement	NN
cord-356188-rwf78stz	377	80	-	-	HYPH
cord-356188-rwf78stz	377	81	dependent	dependent	JJ
cord-356188-rwf78stz	377	82	neutralization	neutralization	NN
cord-356188-rwf78stz	377	83	of	of	IN
cord-356188-rwf78stz	377	84	influenza	influenza	NN
cord-356188-rwf78stz	377	85	virus	virus	NN
cord-356188-rwf78stz	377	86	by	by	IN
cord-356188-rwf78stz	377	87	a	a	DT
cord-356188-rwf78stz	377	88	serum	serum	NN
cord-356188-rwf78stz	377	89	mannose	mannose	NN
cord-356188-rwf78stz	377	90	-	-	HYPH
cord-356188-rwf78stz	377	91	binding	bind	VBG
cord-356188-rwf78stz	377	92	lectin	lectin	NN
cord-356188-rwf78stz	377	93	Human	Human	NNP
cord-356188-rwf78stz	377	94	mannan	mannan	NNP
cord-356188-rwf78stz	377	95	-	-	HYPH
cord-356188-rwf78stz	377	96	binding	bind	VBG
cord-356188-rwf78stz	377	97	lectin	lectin	NN
cord-356188-rwf78stz	377	98	inhibits	inhibit	VBZ
cord-356188-rwf78stz	377	99	the	the	DT
cord-356188-rwf78stz	377	100	infection	infection	NN
cord-356188-rwf78stz	377	101	of	of	IN
cord-356188-rwf78stz	377	102	influenza	influenza	NN
cord-356188-rwf78stz	377	103	A	a	DT
cord-356188-rwf78stz	377	104	virus	virus	NN
cord-356188-rwf78stz	377	105	without	without	IN
cord-356188-rwf78stz	377	106	complement	complement	NN
cord-356188-rwf78stz	377	107	Mannose	mannose	NN
cord-356188-rwf78stz	377	108	-	-	HYPH
cord-356188-rwf78stz	377	109	binding	bind	VBG
cord-356188-rwf78stz	377	110	lectin	lectin	NN
cord-356188-rwf78stz	377	111	deficiency	deficiency	NN
cord-356188-rwf78stz	377	112	and	and	CC
cord-356188-rwf78stz	377	113	respiratory	respiratory	JJ
cord-356188-rwf78stz	377	114	tract	tract	NN
cord-356188-rwf78stz	377	115	infection	infection	NN
cord-356188-rwf78stz	378	1	No	no	DT
cord-356188-rwf78stz	378	2	association	association	NN
cord-356188-rwf78stz	378	3	between	between	IN
cord-356188-rwf78stz	378	4	mannose	mannose	NN
cord-356188-rwf78stz	378	5	-	-	HYPH
cord-356188-rwf78stz	378	6	binding	bind	VBG
cord-356188-rwf78stz	378	7	lectin	lectin	NN
cord-356188-rwf78stz	378	8	deficiency	deficiency	NN
cord-356188-rwf78stz	378	9	and	and	CC
cord-356188-rwf78stz	378	10	H1N1	H1N1	NNP
cord-356188-rwf78stz	378	11	2009	2009	CD
cord-356188-rwf78stz	378	12	infection	infection	NN
cord-356188-rwf78stz	378	13	observed	observe	VBD
cord-356188-rwf78stz	378	14	during	during	IN
cord-356188-rwf78stz	378	15	the	the	DT
cord-356188-rwf78stz	378	16	first	first	JJ
cord-356188-rwf78stz	378	17	season	season	NN
cord-356188-rwf78stz	378	18	of	of	IN
cord-356188-rwf78stz	378	19	this	this	DT
cord-356188-rwf78stz	378	20	novel	novel	JJ
cord-356188-rwf78stz	378	21	pandemic	pandemic	NN
cord-356188-rwf78stz	378	22	influenza	influenza	NN
cord-356188-rwf78stz	378	23	virus	virus	NN
cord-356188-rwf78stz	379	1	The	the	DT
cord-356188-rwf78stz	379	2	authors	author	NNS
cord-356188-rwf78stz	379	3	are	be	VBP
cord-356188-rwf78stz	379	4	funded	fund	VBN
cord-356188-rwf78stz	379	5	in	in	IN
cord-356188-rwf78stz	379	6	part	part	NN
cord-356188-rwf78stz	379	7	by	by	IN
cord-356188-rwf78stz	379	8	U.S.	U.S.	NNP
cord-356188-rwf78stz	379	9	National	National	NNP
cord-356188-rwf78stz	379	10	Institutes	Institutes	NNPS
cord-356188-rwf78stz	379	11	of	of	IN
cord-356188-rwf78stz	379	12	Health	Health	NNP
cord-356188-rwf78stz	379	13	/	/	SYM
cord-356188-rwf78stz	379	14	National	National	NNP
cord-356188-rwf78stz	379	15	Institute	Institute	NNP
cord-356188-rwf78stz	379	16	of	of	IN
cord-356188-rwf78stz	379	17	Allergy	Allergy	NNP
cord-356188-rwf78stz	379	18	and	and	CC
cord-356188-rwf78stz	379	19	Infectious	Infectious	NNP
cord-356188-rwf78stz	379	20	Diseases	Diseases	NNPS
cord-356188-rwf78stz	379	21	contracts	contract	NNS
cord-356188-rwf78stz	379	22	HHSN266200700005C	hhsn266200700005c	CD
cord-356188-rwf78stz	380	1	(	(	-LRB-
cord-356188-rwf78stz	380	2	St.	St.	NNP
cord-356188-rwf78stz	380	3	Jude	Jude	NNP
cord-356188-rwf78stz	380	4	Center	Center	NNP
cord-356188-rwf78stz	380	5	of	of	IN
cord-356188-rwf78stz	380	6	Excellence	Excellence	NNP
cord-356188-rwf78stz	380	7	for	for	IN
cord-356188-rwf78stz	380	8	Influenza	Influenza	NNP
cord-356188-rwf78stz	380	9	Research	Research	NNP
cord-356188-rwf78stz	380	10	and	and	CC
cord-356188-rwf78stz	380	11	Surveillance	Surveillance	NNP
cord-356188-rwf78stz	380	12	)	)	-RRB-
cord-356188-rwf78stz	380	13	and	and	CC
cord-356188-rwf78stz	381	1	HHSN272200800058C	HHSN272200800058C	.
cord-356188-rwf78stz	382	1	(	(	-LRB-
cord-356188-rwf78stz	382	2	Systems	Systems	NNP
cord-356188-rwf78stz	382	3	Influenza	Influenza	NNP
cord-356188-rwf78stz	382	4	)	)	-RRB-
cord-356188-rwf78stz	382	5	and	and	CC
cord-356188-rwf78stz	382	6	the	the	DT
cord-356188-rwf78stz	382	7	American	american	JJ
cord-356188-rwf78stz	382	8	Lebanese	lebanese	JJ
cord-356188-rwf78stz	382	9	Syrian	syrian	JJ
cord-356188-rwf78stz	382	10	Associated	Associated	NNP
cord-356188-rwf78stz	382	11	Charities	Charities	NNPS
cord-356188-rwf78stz	382	12	(	(	-LRB-
cord-356188-rwf78stz	382	13	ALSAC	ALSAC	NNP
cord-356188-rwf78stz	382	14	)	)	-RRB-
cord-356188-rwf78stz	382	15	.	.	.