id sid tid token lemma pos cord-347246-0vofftmj 1 1 key key NN cord-347246-0vofftmj 1 2 : : : cord-347246-0vofftmj 2 1 cord-347246 cord-347246 NNS cord-347246-0vofftmj 2 2 - - HYPH cord-347246-0vofftmj 2 3 0vofftmj 0vofftmj CD cord-347246-0vofftmj 2 4 authors author NNS cord-347246-0vofftmj 2 5 : : : cord-347246-0vofftmj 2 6 Everitt Everitt NNP cord-347246-0vofftmj 2 7 , , , cord-347246-0vofftmj 2 8 J J NNP cord-347246-0vofftmj 2 9 I I NNP cord-347246-0vofftmj 2 10 ; ; : cord-347246-0vofftmj 2 11 Richter Richter NNP cord-347246-0vofftmj 2 12 , , , cord-347246-0vofftmj 2 13 C C NNP cord-347246-0vofftmj 2 14 B B NNP cord-347246-0vofftmj 2 15 title title NN cord-347246-0vofftmj 2 16 : : : cord-347246-0vofftmj 2 17 Infectious infectious JJ cord-347246-0vofftmj 2 18 diseases disease NNS cord-347246-0vofftmj 2 19 of of IN cord-347246-0vofftmj 2 20 the the DT cord-347246-0vofftmj 2 21 upper upper JJ cord-347246-0vofftmj 2 22 respiratory respiratory JJ cord-347246-0vofftmj 2 23 tract tract NN cord-347246-0vofftmj 2 24 : : : cord-347246-0vofftmj 2 25 implications implication NNS cord-347246-0vofftmj 2 26 for for IN cord-347246-0vofftmj 2 27 toxicology toxicology NN cord-347246-0vofftmj 2 28 studies study NNS cord-347246-0vofftmj 2 29 . . . cord-347246-0vofftmj 3 1 date date NN cord-347246-0vofftmj 3 2 : : : cord-347246-0vofftmj 3 3 1990 1990 CD cord-347246-0vofftmj 3 4 - - SYM cord-347246-0vofftmj 3 5 04 04 CD cord-347246-0vofftmj 3 6 - - SYM cord-347246-0vofftmj 3 7 17 17 CD cord-347246-0vofftmj 3 8 journal journal NN cord-347246-0vofftmj 3 9 : : : cord-347246-0vofftmj 4 1 Environ Environ NNP cord-347246-0vofftmj 4 2 Health Health NNP cord-347246-0vofftmj 4 3 Perspect Perspect NNP cord-347246-0vofftmj 4 4 DOI DOI NNP cord-347246-0vofftmj 4 5 : : : cord-347246-0vofftmj 5 1 nan nan NNP cord-347246-0vofftmj 5 2 sha sha NNP cord-347246-0vofftmj 5 3 : : : cord-347246-0vofftmj 6 1 3b5579588b12f1f4bd5e6c1eea4c8ba0258a4f57 3b5579588b12f1f4bd5e6c1eea4c8ba0258a4f57 CD cord-347246-0vofftmj 6 2 doc_id doc_id CD cord-347246-0vofftmj 6 3 : : : cord-347246-0vofftmj 6 4 347246 347246 CD cord-347246-0vofftmj 6 5 cord_uid cord_uid NNS cord-347246-0vofftmj 6 6 : : : cord-347246-0vofftmj 6 7 0vofftmj 0vofftmj . cord-347246-0vofftmj 7 1 The the DT cord-347246-0vofftmj 7 2 consequences consequence NNS cord-347246-0vofftmj 7 3 of of IN cord-347246-0vofftmj 7 4 adventitious adventitious JJ cord-347246-0vofftmj 7 5 infectious infectious JJ cord-347246-0vofftmj 7 6 agents agent NNS cord-347246-0vofftmj 7 7 upon upon IN cord-347246-0vofftmj 7 8 the the DT cord-347246-0vofftmj 7 9 interpretation interpretation NN cord-347246-0vofftmj 7 10 of of IN cord-347246-0vofftmj 7 11 toxicology toxicology NN cord-347246-0vofftmj 7 12 studies study NNS cord-347246-0vofftmj 7 13 performed perform VBN cord-347246-0vofftmj 7 14 in in IN cord-347246-0vofftmj 7 15 rats rat NNS cord-347246-0vofftmj 7 16 and and CC cord-347246-0vofftmj 7 17 mice mouse NNS cord-347246-0vofftmj 7 18 are be VBP cord-347246-0vofftmj 7 19 incompletely incompletely RB cord-347246-0vofftmj 7 20 understood understand VBN cord-347246-0vofftmj 7 21 . . . cord-347246-0vofftmj 8 1 Several several JJ cord-347246-0vofftmj 8 2 prevalent prevalent JJ cord-347246-0vofftmj 8 3 murine murine JJ cord-347246-0vofftmj 8 4 pathogens pathogen NNS cord-347246-0vofftmj 8 5 cause cause VBP cord-347246-0vofftmj 8 6 alterations alteration NNS cord-347246-0vofftmj 8 7 of of IN cord-347246-0vofftmj 8 8 the the DT cord-347246-0vofftmj 8 9 respiratory respiratory JJ cord-347246-0vofftmj 8 10 system system NN cord-347246-0vofftmj 8 11 that that WDT cord-347246-0vofftmj 8 12 can can MD cord-347246-0vofftmj 8 13 confuse confuse VB cord-347246-0vofftmj 8 14 the the DT cord-347246-0vofftmj 8 15 assessment assessment NN cord-347246-0vofftmj 8 16 of of IN cord-347246-0vofftmj 8 17 chemically chemically RB cord-347246-0vofftmj 8 18 induced induce VBN cord-347246-0vofftmj 8 19 airway airway NN cord-347246-0vofftmj 8 20 injury injury NN cord-347246-0vofftmj 8 21 . . . cord-347246-0vofftmj 9 1 In in IN cord-347246-0vofftmj 9 2 some some DT cord-347246-0vofftmj 9 3 instances instance NNS cord-347246-0vofftmj 9 4 the the DT cord-347246-0vofftmj 9 5 pathogenesis pathogenesis NN cord-347246-0vofftmj 9 6 of of IN cord-347246-0vofftmj 9 7 infection infection NN cord-347246-0vofftmj 9 8 with with IN cord-347246-0vofftmj 9 9 these these DT cord-347246-0vofftmj 9 10 agents agent NNS cord-347246-0vofftmj 9 11 has have VBZ cord-347246-0vofftmj 9 12 been be VBN cord-347246-0vofftmj 9 13 relatively relatively RB cord-347246-0vofftmj 9 14 well well RB cord-347246-0vofftmj 9 15 studied study VBN cord-347246-0vofftmj 9 16 in in IN cord-347246-0vofftmj 9 17 the the DT cord-347246-0vofftmj 9 18 lower low JJR cord-347246-0vofftmj 9 19 respiratory respiratory JJ cord-347246-0vofftmj 9 20 tract tract NN cord-347246-0vofftmj 9 21 . . . cord-347246-0vofftmj 10 1 However however RB cord-347246-0vofftmj 10 2 , , , cord-347246-0vofftmj 10 3 there there EX cord-347246-0vofftmj 10 4 are be VBP cord-347246-0vofftmj 10 5 few few JJ cord-347246-0vofftmj 10 6 well well RB cord-347246-0vofftmj 10 7 - - HYPH cord-347246-0vofftmj 10 8 controlled control VBN cord-347246-0vofftmj 10 9 studies study NNS cord-347246-0vofftmj 10 10 that that WDT cord-347246-0vofftmj 10 11 have have VBP cord-347246-0vofftmj 10 12 examined examine VBN cord-347246-0vofftmj 10 13 the the DT cord-347246-0vofftmj 10 14 upper upper JJ cord-347246-0vofftmj 10 15 respiratory respiratory JJ cord-347246-0vofftmj 10 16 region region NN cord-347246-0vofftmj 10 17 , , , cord-347246-0vofftmj 10 18 which which WDT cord-347246-0vofftmj 10 19 result result VBP cord-347246-0vofftmj 10 20 in in IN cord-347246-0vofftmj 10 21 interpretive interpretive JJ cord-347246-0vofftmj 10 22 problems problem NNS cord-347246-0vofftmj 10 23 for for IN cord-347246-0vofftmj 10 24 toxicologic toxicologic NN cord-347246-0vofftmj 10 25 pathologists pathologist NNS cord-347246-0vofftmj 10 26 . . . cord-347246-0vofftmj 11 1 The the DT cord-347246-0vofftmj 11 2 conduct conduct NN cord-347246-0vofftmj 11 3 and and CC cord-347246-0vofftmj 11 4 interpretation interpretation NN cord-347246-0vofftmj 11 5 of of IN cord-347246-0vofftmj 11 6 both both DT cord-347246-0vofftmj 11 7 short short JJ cord-347246-0vofftmj 11 8 - - HYPH cord-347246-0vofftmj 11 9 term term NN cord-347246-0vofftmj 11 10 and and CC cord-347246-0vofftmj 11 11 chronic chronic JJ cord-347246-0vofftmj 11 12 rodent rodent NN cord-347246-0vofftmj 11 13 bioassays bioassay NNS cord-347246-0vofftmj 11 14 can can MD cord-347246-0vofftmj 11 15 be be VB cord-347246-0vofftmj 11 16 compromised compromise VBN cord-347246-0vofftmj 11 17 by by IN cord-347246-0vofftmj 11 18 both both CC cord-347246-0vofftmj 11 19 the the DT cord-347246-0vofftmj 11 20 clinical clinical JJ cord-347246-0vofftmj 11 21 and and CC cord-347246-0vofftmj 11 22 subclinical subclinical JJ cord-347246-0vofftmj 11 23 manifestations manifestation NNS cord-347246-0vofftmj 11 24 of of IN cord-347246-0vofftmj 11 25 infectious infectious JJ cord-347246-0vofftmj 11 26 diseases disease NNS cord-347246-0vofftmj 11 27 . . . cord-347246-0vofftmj 12 1 This this DT cord-347246-0vofftmj 12 2 paper paper NN cord-347246-0vofftmj 12 3 reviews review VBZ cord-347246-0vofftmj 12 4 several several JJ cord-347246-0vofftmj 12 5 important important JJ cord-347246-0vofftmj 12 6 infectious infectious JJ cord-347246-0vofftmj 12 7 diseases disease NNS cord-347246-0vofftmj 12 8 of of IN cord-347246-0vofftmj 12 9 the the DT cord-347246-0vofftmj 12 10 upper upper JJ cord-347246-0vofftmj 12 11 airway airway NN cord-347246-0vofftmj 12 12 of of IN cord-347246-0vofftmj 12 13 rats rat NNS cord-347246-0vofftmj 12 14 and and CC cord-347246-0vofftmj 12 15 mice mouse NNS cord-347246-0vofftmj 12 16 and and CC cord-347246-0vofftmj 12 17 discusses discuss VBZ cord-347246-0vofftmj 12 18 the the DT cord-347246-0vofftmj 12 19 potential potential JJ cord-347246-0vofftmj 12 20 influence influence NN cord-347246-0vofftmj 12 21 of of IN cord-347246-0vofftmj 12 22 these these DT cord-347246-0vofftmj 12 23 conditions condition NNS cord-347246-0vofftmj 12 24 on on IN cord-347246-0vofftmj 12 25 the the DT cord-347246-0vofftmj 12 26 results result NNS cord-347246-0vofftmj 12 27 of of IN cord-347246-0vofftmj 12 28 toxicology toxicology NN cord-347246-0vofftmj 12 29 studies study NNS cord-347246-0vofftmj 12 30 . . . cord-347246-0vofftmj 13 1 The the DT cord-347246-0vofftmj 13 2 validity validity NN cord-347246-0vofftmj 13 3 and and CC cord-347246-0vofftmj 13 4 reproducibility reproducibility NN cord-347246-0vofftmj 13 5 of of IN cord-347246-0vofftmj 13 6 rodent rodent NN cord-347246-0vofftmj 13 7 toxicology toxicology NN cord-347246-0vofftmj 13 8 studies study NNS cord-347246-0vofftmj 13 9 depend depend VBP cord-347246-0vofftmj 13 10 , , , cord-347246-0vofftmj 13 11 in in IN cord-347246-0vofftmj 13 12 part part NN cord-347246-0vofftmj 13 13 , , , cord-347246-0vofftmj 13 14 on on IN cord-347246-0vofftmj 13 15 the the DT cord-347246-0vofftmj 13 16 interaction interaction NN cord-347246-0vofftmj 13 17 of of IN cord-347246-0vofftmj 13 18 numerous numerous JJ cord-347246-0vofftmj 13 19 environmental environmental JJ cord-347246-0vofftmj 13 20 , , , cord-347246-0vofftmj 13 21 microbial microbial JJ cord-347246-0vofftmj 13 22 , , , cord-347246-0vofftmj 13 23 and and CC cord-347246-0vofftmj 13 24 genetic genetic JJ cord-347246-0vofftmj 13 25 factors factor NNS cord-347246-0vofftmj 13 26 . . . cord-347246-0vofftmj 14 1 Control control NN cord-347246-0vofftmj 14 2 of of IN cord-347246-0vofftmj 14 3 important important JJ cord-347246-0vofftmj 14 4 animal animal NN cord-347246-0vofftmj 14 5 and and CC cord-347246-0vofftmj 14 6 extrinsic extrinsic JJ cord-347246-0vofftmj 14 7 factors factor NNS cord-347246-0vofftmj 14 8 forms form VBZ cord-347246-0vofftmj 14 9 the the DT cord-347246-0vofftmj 14 10 basis basis NN cord-347246-0vofftmj 14 11 of of IN cord-347246-0vofftmj 14 12 laboratory laboratory NN cord-347246-0vofftmj 14 13 animal animal NN cord-347246-0vofftmj 14 14 science science NN cord-347246-0vofftmj 14 15 programs program NNS cord-347246-0vofftmj 14 16 in in IN cord-347246-0vofftmj 14 17 toxicology toxicology NN cord-347246-0vofftmj 14 18 . . . cord-347246-0vofftmj 15 1 Despite despite IN cord-347246-0vofftmj 15 2 numerous numerous JJ cord-347246-0vofftmj 15 3 advances advance NNS cord-347246-0vofftmj 15 4 and and CC cord-347246-0vofftmj 15 5 sophistication sophistication NN cord-347246-0vofftmj 15 6 in in IN cord-347246-0vofftmj 15 7 the the DT cord-347246-0vofftmj 15 8 field field NN cord-347246-0vofftmj 15 9 of of IN cord-347246-0vofftmj 15 10 laboratory laboratory NN cord-347246-0vofftmj 15 11 animal animal NN cord-347246-0vofftmj 15 12 medicine medicine NN cord-347246-0vofftmj 15 13 , , , cord-347246-0vofftmj 15 14 adventitious adventitious JJ cord-347246-0vofftmj 15 15 murine murine JJ cord-347246-0vofftmj 15 16 microbial microbial JJ cord-347246-0vofftmj 15 17 agents agent NNS cord-347246-0vofftmj 15 18 continue continue VBP cord-347246-0vofftmj 15 19 to to TO cord-347246-0vofftmj 15 20 pose pose VB cord-347246-0vofftmj 15 21 a a DT cord-347246-0vofftmj 15 22 threat threat NN cord-347246-0vofftmj 15 23 to to IN cord-347246-0vofftmj 15 24 both both DT cord-347246-0vofftmj 15 25 shortand shortand JJ cord-347246-0vofftmj 15 26 long long JJ cord-347246-0vofftmj 15 27 - - HYPH cord-347246-0vofftmj 15 28 term term NN cord-347246-0vofftmj 15 29 studies study NNS cord-347246-0vofftmj 15 30 that that WDT cord-347246-0vofftmj 15 31 use use VBP cord-347246-0vofftmj 15 32 rats rat NNS cord-347246-0vofftmj 15 33 and and CC cord-347246-0vofftmj 15 34 mice mouse NNS cord-347246-0vofftmj 15 35 . . . cord-347246-0vofftmj 16 1 Programs program NNS cord-347246-0vofftmj 16 2 for for IN cord-347246-0vofftmj 16 3 prevention prevention NN cord-347246-0vofftmj 16 4 , , , cord-347246-0vofftmj 16 5 detection detection NN cord-347246-0vofftmj 16 6 , , , cord-347246-0vofftmj 16 7 elimination elimination NN cord-347246-0vofftmj 16 8 , , , cord-347246-0vofftmj 16 9 and and CC cord-347246-0vofftmj 16 10 control control NN cord-347246-0vofftmj 16 11 of of IN cord-347246-0vofftmj 16 12 rodent rodent NN cord-347246-0vofftmj 16 13 infectious infectious JJ cord-347246-0vofftmj 16 14 agents agent NNS cord-347246-0vofftmj 16 15 are be VBP cord-347246-0vofftmj 16 16 necessary necessary JJ cord-347246-0vofftmj 16 17 in in IN cord-347246-0vofftmj 16 18 toxicology toxicology NN cord-347246-0vofftmj 16 19 research research NN cord-347246-0vofftmj 16 20 and and CC cord-347246-0vofftmj 16 21 testing testing NN cord-347246-0vofftmj 16 22 . . . cord-347246-0vofftmj 17 1 These these DT cord-347246-0vofftmj 17 2 programs program NNS cord-347246-0vofftmj 17 3 are be VBP cord-347246-0vofftmj 17 4 of of IN cord-347246-0vofftmj 17 5 particular particular JJ cord-347246-0vofftmj 17 6 importance importance NN cord-347246-0vofftmj 17 7 to to IN cord-347246-0vofftmj 17 8 both both DT cord-347246-0vofftmj 17 9 toxicologists toxicologist NNS cord-347246-0vofftmj 17 10 and and CC cord-347246-0vofftmj 17 11 pathologists pathologist NNS cord-347246-0vofftmj 17 12 responsible responsible JJ cord-347246-0vofftmj 17 13 for for IN cord-347246-0vofftmj 17 14 conducting conduct VBG cord-347246-0vofftmj 17 15 and and CC cord-347246-0vofftmj 17 16 interpreting interpret VBG cord-347246-0vofftmj 17 17 rodent rodent NN cord-347246-0vofftmj 17 18 bioassays bioassay NNS cord-347246-0vofftmj 17 19 . . . cord-347246-0vofftmj 18 1 Specific specific JJ cord-347246-0vofftmj 18 2 procedures procedure NNS cord-347246-0vofftmj 18 3 and and CC cord-347246-0vofftmj 18 4 equipment equipment NN cord-347246-0vofftmj 18 5 used use VBN cord-347246-0vofftmj 18 6 in in IN cord-347246-0vofftmj 18 7 inhalation inhalation NN cord-347246-0vofftmj 18 8 toxicity toxicity NN cord-347246-0vofftmj 18 9 experiments experiment NNS cord-347246-0vofftmj 18 10 can can MD cord-347246-0vofftmj 18 11 contribute contribute VB cord-347246-0vofftmj 18 12 significantly significantly RB cord-347246-0vofftmj 18 13 to to IN cord-347246-0vofftmj 18 14 the the DT cord-347246-0vofftmj 18 15 spread spread NN cord-347246-0vofftmj 18 16 of of IN cord-347246-0vofftmj 18 17 disease disease NN cord-347246-0vofftmj 18 18 and and CC cord-347246-0vofftmj 18 19 the the DT cord-347246-0vofftmj 18 20 interaction interaction NN cord-347246-0vofftmj 18 21 of of IN cord-347246-0vofftmj 18 22 infectious infectious JJ cord-347246-0vofftmj 18 23 agents agent NNS cord-347246-0vofftmj 18 24 with with IN cord-347246-0vofftmj 18 25 inhaled inhale VBN cord-347246-0vofftmj 18 26 toxicants toxicant NNS cord-347246-0vofftmj 18 27 . . . cord-347246-0vofftmj 19 1 Many many JJ cord-347246-0vofftmj 19 2 factors factor NNS cord-347246-0vofftmj 19 3 , , , cord-347246-0vofftmj 19 4 such such JJ cord-347246-0vofftmj 19 5 as as IN cord-347246-0vofftmj 19 6 inhalation inhalation NN cord-347246-0vofftmj 19 7 caging caging NN cord-347246-0vofftmj 19 8 ; ; : cord-347246-0vofftmj 19 9 cage cage NN cord-347246-0vofftmj 19 10 rotation rotation NN cord-347246-0vofftmj 19 11 schemes scheme NNS cord-347246-0vofftmj 19 12 ; ; : cord-347246-0vofftmj 19 13 inhalation inhalation NN cord-347246-0vofftmj 19 14 chamber chamber NN cord-347246-0vofftmj 19 15 microenvironments microenvironment NNS cord-347246-0vofftmj 19 16 ; ; : cord-347246-0vofftmj 19 17 food food NN cord-347246-0vofftmj 19 18 and and CC cord-347246-0vofftmj 19 19 water water NN cord-347246-0vofftmj 19 20 deprivation deprivation NN cord-347246-0vofftmj 19 21 during during IN cord-347246-0vofftmj 19 22 exposures exposure NNS cord-347246-0vofftmj 19 23 ; ; : cord-347246-0vofftmj 19 24 and and CC cord-347246-0vofftmj 19 25 stresses stress NNS cord-347246-0vofftmj 19 26 from from IN cord-347246-0vofftmj 19 27 crowding crowd VBG cord-347246-0vofftmj 19 28 , , , cord-347246-0vofftmj 19 29 frequent frequent JJ cord-347246-0vofftmj 19 30 handling handling NN cord-347246-0vofftmj 19 31 , , , cord-347246-0vofftmj 19 32 and and CC cord-347246-0vofftmj 19 33 servicing servicing NN cord-347246-0vofftmj 19 34 of of IN cord-347246-0vofftmj 19 35 animals animal NNS cord-347246-0vofftmj 19 36 , , , cord-347246-0vofftmj 19 37 all all DT cord-347246-0vofftmj 19 38 play play VBP cord-347246-0vofftmj 19 39 important important JJ cord-347246-0vofftmj 19 40 roles role NNS cord-347246-0vofftmj 19 41 in in IN cord-347246-0vofftmj 19 42 the the DT cord-347246-0vofftmj 19 43 interplay interplay NN cord-347246-0vofftmj 19 44 between between IN cord-347246-0vofftmj 19 45 pathogen pathogen NN cord-347246-0vofftmj 19 46 and and CC cord-347246-0vofftmj 19 47 chemical chemical NN cord-347246-0vofftmj 19 48 exposure exposure NN cord-347246-0vofftmj 19 49 . . . cord-347246-0vofftmj 20 1 The the DT cord-347246-0vofftmj 20 2 complications complication NNS cord-347246-0vofftmj 20 3 of of IN cord-347246-0vofftmj 20 4 rodent rodent NN cord-347246-0vofftmj 20 5 infectious infectious JJ cord-347246-0vofftmj 20 6 agents agent NNS cord-347246-0vofftmj 20 7 to to IN cord-347246-0vofftmj 20 8 toxicology toxicology NN cord-347246-0vofftmj 20 9 research research NN cord-347246-0vofftmj 20 10 and and CC cord-347246-0vofftmj 20 11 testing testing NN cord-347246-0vofftmj 20 12 has have VBZ cord-347246-0vofftmj 20 13 been be VBN cord-347246-0vofftmj 20 14 the the DT cord-347246-0vofftmj 20 15 subject subject NN cord-347246-0vofftmj 20 16 of of IN cord-347246-0vofftmj 20 17 increasing increase VBG cord-347246-0vofftmj 20 18 awareness awareness NN cord-347246-0vofftmj 20 19 and and CC cord-347246-0vofftmj 20 20 review review NN cord-347246-0vofftmj 20 21 ( ( -LRB- cord-347246-0vofftmj 20 22 1 1 CD cord-347246-0vofftmj 20 23 , , , cord-347246-0vofftmj 20 24 2 2 CD cord-347246-0vofftmj 20 25 ) ) -RRB- cord-347246-0vofftmj 20 26 . . . cord-347246-0vofftmj 21 1 Recent recent JJ cord-347246-0vofftmj 21 2 rodent rodent NN cord-347246-0vofftmj 21 3 serology serology NN cord-347246-0vofftmj 21 4 surveys survey NNS cord-347246-0vofftmj 21 5 indicate indicate VBP cord-347246-0vofftmj 21 6 that that IN cord-347246-0vofftmj 21 7 sialodacryoadenitis sialodacryoadenitis NNP cord-347246-0vofftmj 21 8 virus virus NN cord-347246-0vofftmj 21 9 ( ( -LRB- cord-347246-0vofftmj 21 10 SDAV SDAV NNP cord-347246-0vofftmj 21 11 ) ) -RRB- cord-347246-0vofftmj 21 12 , , , cord-347246-0vofftmj 21 13 Sendai Sendai NNP cord-347246-0vofftmj 21 14 virus virus NN cord-347246-0vofftmj 21 15 , , , cord-347246-0vofftmj 21 16 and and CC cord-347246-0vofftmj 21 17 Mycoplasrna Mycoplasrna NNP cord-347246-0vofftmj 21 18 pulmonis pulmonis NNP cord-347246-0vofftmj 21 19 are be VBP cord-347246-0vofftmj 21 20 three three CD cord-347246-0vofftmj 21 21 of of IN cord-347246-0vofftmj 21 22 the the DT cord-347246-0vofftmj 21 23 most most RBS cord-347246-0vofftmj 21 24 prevalent prevalent JJ cord-347246-0vofftmj 21 25 murine murine JJ cord-347246-0vofftmj 21 26 pathogens pathogen NNS cord-347246-0vofftmj 21 27 ( ( -LRB- cord-347246-0vofftmj 21 28 3 3 CD cord-347246-0vofftmj 21 29 ) ) -RRB- cord-347246-0vofftmj 21 30 . . . cord-347246-0vofftmj 22 1 All all DT cord-347246-0vofftmj 22 2 three three CD cord-347246-0vofftmj 22 3 agents agent NNS cord-347246-0vofftmj 22 4 cause cause VBP cord-347246-0vofftmj 22 5 significant significant JJ cord-347246-0vofftmj 22 6 rodent rodent NN cord-347246-0vofftmj 22 7 respiratory respiratory JJ cord-347246-0vofftmj 22 8 disease disease NN cord-347246-0vofftmj 22 9 , , , cord-347246-0vofftmj 22 10 with with IN cord-347246-0vofftmj 22 11 lesions lesion NNS cord-347246-0vofftmj 22 12 in in IN cord-347246-0vofftmj 22 13 the the DT cord-347246-0vofftmj 22 14 upper upper JJ cord-347246-0vofftmj 22 15 airways airway NNS cord-347246-0vofftmj 22 16 , , , cord-347246-0vofftmj 22 17 including include VBG cord-347246-0vofftmj 22 18 the the DT cord-347246-0vofftmj 22 19 nasal nasal NN cord-347246-0vofftmj 22 20 passages passage NNS cord-347246-0vofftmj 22 21 . . . cord-347246-0vofftmj 23 1 In in IN cord-347246-0vofftmj 23 2 addition addition NN cord-347246-0vofftmj 23 3 to to IN cord-347246-0vofftmj 23 4 being be VBG cord-347246-0vofftmj 23 5 a a DT cord-347246-0vofftmj 23 6 common common JJ cord-347246-0vofftmj 23 7 site site NN cord-347246-0vofftmj 23 8 for for IN cord-347246-0vofftmj 23 9 microbial microbial NN cord-347246-0vofftmj 23 10 - - HYPH cord-347246-0vofftmj 23 11 induced induce VBN cord-347246-0vofftmj 23 12 disease disease NN cord-347246-0vofftmj 23 13 , , , cord-347246-0vofftmj 23 14 the the DT cord-347246-0vofftmj 23 15 upper upper JJ cord-347246-0vofftmj 23 16 respiratory respiratory JJ cord-347246-0vofftmj 23 17 tract tract NN cord-347246-0vofftmj 23 18 is be VBZ cord-347246-0vofftmj 23 19 a a DT cord-347246-0vofftmj 23 20 target target NN cord-347246-0vofftmj 23 21 organ organ NN cord-347246-0vofftmj 23 22 of of IN cord-347246-0vofftmj 23 23 chemically chemically RB cord-347246-0vofftmj 23 24 induced induce VBN cord-347246-0vofftmj 23 25 injury injury NN cord-347246-0vofftmj 23 26 . . . cord-347246-0vofftmj 24 1 This this DT cord-347246-0vofftmj 24 2 paper paper NN cord-347246-0vofftmj 24 3 will will MD cord-347246-0vofftmj 24 4 review review VB cord-347246-0vofftmj 24 5 the the DT cord-347246-0vofftmj 24 6 respiratory respiratory JJ cord-347246-0vofftmj 24 7 pathology pathology NN cord-347246-0vofftmj 24 8 of of IN cord-347246-0vofftmj 24 9 several several JJ cord-347246-0vofftmj 24 10 important important JJ cord-347246-0vofftmj 24 11 murine murine JJ cord-347246-0vofftmj 24 12 pathogens pathogen NNS cord-347246-0vofftmj 24 13 and and CC cord-347246-0vofftmj 24 14 discuss discuss VB cord-347246-0vofftmj 24 15 their -PRON- PRP$ cord-347246-0vofftmj 24 16 importance importance NN cord-347246-0vofftmj 24 17 in in IN cord-347246-0vofftmj 24 18 toxicology toxicology NN cord-347246-0vofftmj 24 19 and and CC cord-347246-0vofftmj 24 20 carcinogenicity carcinogenicity NN cord-347246-0vofftmj 24 21 studies study NNS cord-347246-0vofftmj 24 22 . . . cord-347246-0vofftmj 25 1 Sialodacryoadenitis sialodacryoadenitis JJ cord-347246-0vofftmj 25 2 virus virus NN cord-347246-0vofftmj 25 3 is be VBZ cord-347246-0vofftmj 25 4 a a DT cord-347246-0vofftmj 25 5 common common JJ cord-347246-0vofftmj 25 6 , , , cord-347246-0vofftmj 25 7 highly highly RB cord-347246-0vofftmj 25 8 infectious infectious JJ cord-347246-0vofftmj 25 9 coronavirus coronavirus NN cord-347246-0vofftmj 25 10 affecting affect VBG cord-347246-0vofftmj 25 11 rats rat NNS cord-347246-0vofftmj 25 12 and and CC cord-347246-0vofftmj 25 13 causing cause VBG cord-347246-0vofftmj 25 14 a a DT cord-347246-0vofftmj 25 15 selflimiting selflimite VBG cord-347246-0vofftmj 25 16 necrosis necrosis NN cord-347246-0vofftmj 25 17 and and CC cord-347246-0vofftmj 25 18 inflammation inflammation NN cord-347246-0vofftmj 25 19 of of IN cord-347246-0vofftmj 25 20 mixed mixed JJ cord-347246-0vofftmj 25 21 or or CC cord-347246-0vofftmj 25 22 serous serous JJ cord-347246-0vofftmj 25 23 salivary salivary JJ cord-347246-0vofftmj 25 24 glands gland NNS cord-347246-0vofftmj 25 25 , , , cord-347246-0vofftmj 25 26 lacrimal lacrimal JJ cord-347246-0vofftmj 25 27 glands gland NNS cord-347246-0vofftmj 25 28 , , , cord-347246-0vofftmj 25 29 and and CC cord-347246-0vofftmj 25 30 upper upper JJ cord-347246-0vofftmj 25 31 airway airway NN cord-347246-0vofftmj 25 32 epithelium epithelium NN cord-347246-0vofftmj 25 33 ( ( -LRB- cord-347246-0vofftmj 25 34 4 4 CD cord-347246-0vofftmj 25 35 , , , cord-347246-0vofftmj 25 36 5 5 CD cord-347246-0vofftmj 25 37 ) ) -RRB- cord-347246-0vofftmj 25 38 . . . cord-347246-0vofftmj 26 1 Respiratory respiratory JJ cord-347246-0vofftmj 26 2 tract tract NN cord-347246-0vofftmj 26 3 lesions lesion NNS cord-347246-0vofftmj 26 4 are be VBP cord-347246-0vofftmj 26 5 generally generally RB cord-347246-0vofftmj 26 6 confined confine VBN cord-347246-0vofftmj 26 7 to to IN cord-347246-0vofftmj 26 8 the the DT cord-347246-0vofftmj 26 9 upper upper JJ cord-347246-0vofftmj 26 10 airway airway NN cord-347246-0vofftmj 26 11 and and CC cord-347246-0vofftmj 26 12 usually usually RB cord-347246-0vofftmj 26 13 precede precede VBP cord-347246-0vofftmj 26 14 the the DT cord-347246-0vofftmj 26 15 inflammatory inflammatory JJ cord-347246-0vofftmj 26 16 changes change NNS cord-347246-0vofftmj 26 17 that that WDT cord-347246-0vofftmj 26 18 occur occur VBP cord-347246-0vofftmj 26 19 in in IN cord-347246-0vofftmj 26 20 the the DT cord-347246-0vofftmj 26 21 exocrine exocrine JJ cord-347246-0vofftmj 26 22 tissues tissue NNS cord-347246-0vofftmj 26 23 of of IN cord-347246-0vofftmj 26 24 the the DT cord-347246-0vofftmj 26 25 head head NN cord-347246-0vofftmj 26 26 ( ( -LRB- cord-347246-0vofftmj 26 27 6 6 CD cord-347246-0vofftmj 26 28 ) ) -RRB- cord-347246-0vofftmj 26 29 . . . cord-347246-0vofftmj 27 1 Gross gross JJ cord-347246-0vofftmj 27 2 lesions lesion NNS cord-347246-0vofftmj 27 3 consisting consist VBG cord-347246-0vofftmj 27 4 of of IN cord-347246-0vofftmj 27 5 edematous edematous JJ cord-347246-0vofftmj 27 6 and/or and/or CC cord-347246-0vofftmj 27 7 inflammatory inflammatory JJ cord-347246-0vofftmj 27 8 changes change NNS cord-347246-0vofftmj 27 9 are be VBP cord-347246-0vofftmj 27 10 sometimes sometimes RB cord-347246-0vofftmj 27 11 noted note VBN cord-347246-0vofftmj 27 12 in in IN cord-347246-0vofftmj 27 13 extrarespiratory extrarespiratory JJ cord-347246-0vofftmj 27 14 tissue tissue NN cord-347246-0vofftmj 27 15 in in IN cord-347246-0vofftmj 27 16 mixed mixed JJ cord-347246-0vofftmj 27 17 or or CC cord-347246-0vofftmj 27 18 serous serous JJ cord-347246-0vofftmj 27 19 salivary salivary JJ cord-347246-0vofftmj 27 20 glands gland NNS cord-347246-0vofftmj 27 21 , , , cord-347246-0vofftmj 27 22 exorbital exorbital JJ cord-347246-0vofftmj 27 23 lacrimal lacrimal JJ cord-347246-0vofftmj 27 24 glands gland NNS cord-347246-0vofftmj 27 25 , , , cord-347246-0vofftmj 27 26 Harderian harderian JJ cord-347246-0vofftmj 27 27 glands gland NNS cord-347246-0vofftmj 27 28 , , , cord-347246-0vofftmj 27 29 periglandular periglandular JJ cord-347246-0vofftmj 27 30 connective connective JJ cord-347246-0vofftmj 27 31 tissue tissue NN cord-347246-0vofftmj 27 32 , , , cord-347246-0vofftmj 27 33 cervical cervical JJ cord-347246-0vofftmj 27 34 lymph lymph NN cord-347246-0vofftmj 27 35 nodes node NNS cord-347246-0vofftmj 27 36 , , , cord-347246-0vofftmj 27 37 or or CC cord-347246-0vofftmj 27 38 the the DT cord-347246-0vofftmj 27 39 thymus thymus NN cord-347246-0vofftmj 27 40 . . . cord-347246-0vofftmj 28 1 EVERI1 everi1 RB cord-347246-0vofftmj 29 1 T T NNP cord-347246-0vofftmj 29 2 AND and CC cord-347246-0vofftmj 29 3 RICHTER RICHTER NNP cord-347246-0vofftmj 29 4 Microscopic microscopic JJ cord-347246-0vofftmj 29 5 lesions lesion NNS cord-347246-0vofftmj 29 6 in in IN cord-347246-0vofftmj 29 7 experimental experimental JJ cord-347246-0vofftmj 29 8 SDAV SDAV NNP cord-347246-0vofftmj 29 9 infection infection NN cord-347246-0vofftmj 29 10 begin begin VBP cord-347246-0vofftmj 29 11 in in IN cord-347246-0vofftmj 29 12 the the DT cord-347246-0vofftmj 29 13 nasal nasal JJ cord-347246-0vofftmj 29 14 respiratory respiratory JJ cord-347246-0vofftmj 29 15 epithelium epithelium NN cord-347246-0vofftmj 29 16 approximately approximately RB cord-347246-0vofftmj 29 17 48 48 CD cord-347246-0vofftmj 29 18 hr hr NN cord-347246-0vofftmj 29 19 postinfection postinfection NN cord-347246-0vofftmj 29 20 . . . cord-347246-0vofftmj 30 1 Initial initial JJ cord-347246-0vofftmj 30 2 respiratory respiratory JJ cord-347246-0vofftmj 30 3 epithelial epithelial JJ cord-347246-0vofftmj 30 4 necrosis necrosis NN cord-347246-0vofftmj 30 5 accompanied accompany VBN cord-347246-0vofftmj 30 6 by by IN cord-347246-0vofftmj 30 7 congestion congestion NN cord-347246-0vofftmj 30 8 and and CC cord-347246-0vofftmj 30 9 edema edema NN cord-347246-0vofftmj 30 10 is be VBZ cord-347246-0vofftmj 30 11 rapidly rapidly RB cord-347246-0vofftmj 30 12 followed follow VBN cord-347246-0vofftmj 30 13 by by IN cord-347246-0vofftmj 30 14 a a DT cord-347246-0vofftmj 30 15 mixed mixed JJ cord-347246-0vofftmj 30 16 inflammatory inflammatory JJ cord-347246-0vofftmj 30 17 cell cell NN cord-347246-0vofftmj 30 18 infiltrate infiltrate NN cord-347246-0vofftmj 30 19 of of IN cord-347246-0vofftmj 30 20 the the DT cord-347246-0vofftmj 30 21 lamina lamina JJ cord-347246-0vofftmj 30 22 propria propria NN cord-347246-0vofftmj 30 23 . . . cord-347246-0vofftmj 31 1 Necrosis necrosis NN cord-347246-0vofftmj 31 2 primarily primarily RB cord-347246-0vofftmj 31 3 occurs occur VBZ cord-347246-0vofftmj 31 4 in in IN cord-347246-0vofftmj 31 5 the the DT cord-347246-0vofftmj 31 6 respiratory respiratory JJ cord-347246-0vofftmj 31 7 epithelium epithelium NN cord-347246-0vofftmj 31 8 lining line VBG cord-347246-0vofftmj 31 9 the the DT cord-347246-0vofftmj 31 10 ventral ventral JJ cord-347246-0vofftmj 31 11 turbinates turbinate NNS cord-347246-0vofftmj 31 12 and and CC cord-347246-0vofftmj 31 13 lateral lateral JJ cord-347246-0vofftmj 31 14 wall wall NN cord-347246-0vofftmj 31 15 of of IN cord-347246-0vofftmj 31 16 the the DT cord-347246-0vofftmj 31 17 nasal nasal NN cord-347246-0vofftmj 31 18 cavity cavity NN cord-347246-0vofftmj 31 19 but but CC cord-347246-0vofftmj 31 20 usually usually RB cord-347246-0vofftmj 31 21 spares spare VBZ cord-347246-0vofftmj 31 22 the the DT cord-347246-0vofftmj 31 23 olfactory olfactory JJ cord-347246-0vofftmj 31 24 mucosa mucosa NN cord-347246-0vofftmj 31 25 . . . cord-347246-0vofftmj 32 1 The the DT cord-347246-0vofftmj 32 2 nasal nasal NN cord-347246-0vofftmj 32 3 meatuses meatus NNS cord-347246-0vofftmj 32 4 may may MD cord-347246-0vofftmj 32 5 be be VB cord-347246-0vofftmj 32 6 filled fill VBN cord-347246-0vofftmj 32 7 with with IN cord-347246-0vofftmj 32 8 exudate exudate NN cord-347246-0vofftmj 32 9 composed compose VBN cord-347246-0vofftmj 32 10 of of IN cord-347246-0vofftmj 32 11 necrotic necrotic JJ cord-347246-0vofftmj 32 12 epithelial epithelial JJ cord-347246-0vofftmj 32 13 cells cell NNS cord-347246-0vofftmj 32 14 admixed admix VBN cord-347246-0vofftmj 32 15 with with IN cord-347246-0vofftmj 32 16 inflammatory inflammatory JJ cord-347246-0vofftmj 32 17 cells cell NNS cord-347246-0vofftmj 32 18 and and CC cord-347246-0vofftmj 32 19 mucus mucus NN cord-347246-0vofftmj 32 20 . . . cord-347246-0vofftmj 33 1 Serous serous JJ cord-347246-0vofftmj 33 2 mucosal mucosal JJ cord-347246-0vofftmj 33 3 glands gland NNS cord-347246-0vofftmj 33 4 of of IN cord-347246-0vofftmj 33 5 the the DT cord-347246-0vofftmj 33 6 nasopharynx nasopharynx NN cord-347246-0vofftmj 33 7 generally generally RB cord-347246-0vofftmj 33 8 sustain sustain VBP cord-347246-0vofftmj 33 9 relatively relatively RB cord-347246-0vofftmj 33 10 mild mild JJ cord-347246-0vofftmj 33 11 injury injury NN cord-347246-0vofftmj 33 12 ( ( -LRB- cord-347246-0vofftmj 33 13 6 6 CD cord-347246-0vofftmj 33 14 ) ) -RRB- cord-347246-0vofftmj 33 15 , , , cord-347246-0vofftmj 33 16 although although IN cord-347246-0vofftmj 33 17 necrosis necrosis NN cord-347246-0vofftmj 33 18 of of IN cord-347246-0vofftmj 33 19 ducts duct NNS cord-347246-0vofftmj 33 20 and and CC cord-347246-0vofftmj 33 21 acini acini NNP cord-347246-0vofftmj 33 22 does do VBZ cord-347246-0vofftmj 33 23 occur occur VB cord-347246-0vofftmj 33 24 . . . cord-347246-0vofftmj 34 1 Lesions lesion NNS cord-347246-0vofftmj 34 2 similar similar JJ cord-347246-0vofftmj 34 3 to to IN cord-347246-0vofftmj 34 4 those those DT cord-347246-0vofftmj 34 5 in in IN cord-347246-0vofftmj 34 6 the the DT cord-347246-0vofftmj 34 7 nasopharynx nasopharynx NN cord-347246-0vofftmj 34 8 , , , cord-347246-0vofftmj 34 9 but but CC cord-347246-0vofftmj 34 10 milder mild JJR cord-347246-0vofftmj 34 11 and and CC cord-347246-0vofftmj 34 12 less less RBR cord-347246-0vofftmj 34 13 uniform uniform JJ cord-347246-0vofftmj 34 14 , , , cord-347246-0vofftmj 34 15 are be VBP cord-347246-0vofftmj 34 16 found find VBN cord-347246-0vofftmj 34 17 in in IN cord-347246-0vofftmj 34 18 the the DT cord-347246-0vofftmj 34 19 trachea trachea NN cord-347246-0vofftmj 34 20 . . . cord-347246-0vofftmj 35 1 The the DT cord-347246-0vofftmj 35 2 rhinotracheitis rhinotracheitis NN cord-347246-0vofftmj 35 3 of of IN cord-347246-0vofftmj 35 4 SDAV SDAV NNP cord-347246-0vofftmj 35 5 is be VBZ cord-347246-0vofftmj 35 6 usually usually RB cord-347246-0vofftmj 35 7 self self NN cord-347246-0vofftmj 35 8 - - HYPH cord-347246-0vofftmj 35 9 limiting limit VBG cord-347246-0vofftmj 35 10 and and CC cord-347246-0vofftmj 35 11 it -PRON- PRP cord-347246-0vofftmj 35 12 is be VBZ cord-347246-0vofftmj 35 13 resolved resolve VBN cord-347246-0vofftmj 35 14 by by IN cord-347246-0vofftmj 35 15 the the DT cord-347246-0vofftmj 35 16 end end NN cord-347246-0vofftmj 35 17 of of IN cord-347246-0vofftmj 35 18 the the DT cord-347246-0vofftmj 35 19 second second JJ cord-347246-0vofftmj 35 20 week week NN cord-347246-0vofftmj 35 21 of of IN cord-347246-0vofftmj 35 22 infection infection NN cord-347246-0vofftmj 35 23 ( ( -LRB- cord-347246-0vofftmj 35 24 6 6 CD cord-347246-0vofftmj 35 25 ) ) -RRB- cord-347246-0vofftmj 35 26 . . . cord-347246-0vofftmj 36 1 Although although IN cord-347246-0vofftmj 36 2 not not RB cord-347246-0vofftmj 36 3 as as RB cord-347246-0vofftmj 36 4 prevalent prevalent JJ cord-347246-0vofftmj 36 5 or or CC cord-347246-0vofftmj 36 6 as as RB cord-347246-0vofftmj 36 7 severe severe JJ cord-347246-0vofftmj 36 8 as as IN cord-347246-0vofftmj 36 9 upper upper JJ cord-347246-0vofftmj 36 10 respiratory respiratory JJ cord-347246-0vofftmj 36 11 tract tract NN cord-347246-0vofftmj 36 12 lesions lesion NNS cord-347246-0vofftmj 36 13 , , , cord-347246-0vofftmj 36 14 microscopic microscopic JJ cord-347246-0vofftmj 36 15 changes change NNS cord-347246-0vofftmj 36 16 do do VBP cord-347246-0vofftmj 36 17 occur occur VB cord-347246-0vofftmj 36 18 in in IN cord-347246-0vofftmj 36 19 the the DT cord-347246-0vofftmj 36 20 lower low JJR cord-347246-0vofftmj 36 21 respiratory respiratory JJ cord-347246-0vofftmj 36 22 tract tract NN cord-347246-0vofftmj 36 23 in in IN cord-347246-0vofftmj 36 24 experimental experimental JJ cord-347246-0vofftmj 36 25 infections infection NNS cord-347246-0vofftmj 36 26 of of IN cord-347246-0vofftmj 36 27 rats rat NNS cord-347246-0vofftmj 36 28 ( ( -LRB- cord-347246-0vofftmj 36 29 7 7 CD cord-347246-0vofftmj 36 30 ) ) -RRB- cord-347246-0vofftmj 36 31 , , , cord-347246-0vofftmj 36 32 consisting consist VBG cord-347246-0vofftmj 36 33 of of IN cord-347246-0vofftmj 36 34 focal focal JJ cord-347246-0vofftmj 36 35 nonsuppurative nonsuppurative JJ cord-347246-0vofftmj 36 36 bronchiolitis bronchiolitis NN cord-347246-0vofftmj 36 37 and and CC cord-347246-0vofftmj 36 38 peribronchial peribronchial JJ cord-347246-0vofftmj 36 39 lymphocytic lymphocytic JJ cord-347246-0vofftmj 36 40 infiltration infiltration NN cord-347246-0vofftmj 36 41 . . . cord-347246-0vofftmj 37 1 Although although IN cord-347246-0vofftmj 37 2 SDAV SDAV NNP cord-347246-0vofftmj 37 3 infection infection NN cord-347246-0vofftmj 37 4 is be VBZ cord-347246-0vofftmj 37 5 generally generally RB cord-347246-0vofftmj 37 6 a a DT cord-347246-0vofftmj 37 7 self self NN cord-347246-0vofftmj 37 8 - - HYPH cord-347246-0vofftmj 37 9 limiting limit VBG cord-347246-0vofftmj 37 10 disease disease NN cord-347246-0vofftmj 37 11 without without IN cord-347246-0vofftmj 37 12 significant significant JJ cord-347246-0vofftmj 37 13 mortality mortality NN cord-347246-0vofftmj 37 14 , , , cord-347246-0vofftmj 37 15 it -PRON- PRP cord-347246-0vofftmj 37 16 can can MD cord-347246-0vofftmj 37 17 cause cause VB cord-347246-0vofftmj 37 18 marked marked JJ cord-347246-0vofftmj 37 19 effects effect NNS cord-347246-0vofftmj 37 20 on on IN cord-347246-0vofftmj 37 21 toxicology toxicology NN cord-347246-0vofftmj 37 22 studies study NNS cord-347246-0vofftmj 37 23 through through IN cord-347246-0vofftmj 37 24 clinical clinical JJ cord-347246-0vofftmj 37 25 disease disease NN cord-347246-0vofftmj 37 26 or or CC cord-347246-0vofftmj 37 27 subclinical subclinical JJ cord-347246-0vofftmj 37 28 manifestations manifestation NNS cord-347246-0vofftmj 37 29 . . . cord-347246-0vofftmj 38 1 Rats rat NNS cord-347246-0vofftmj 38 2 with with IN cord-347246-0vofftmj 38 3 SDAV SDAV NNP cord-347246-0vofftmj 38 4 infection infection NN cord-347246-0vofftmj 38 5 often often RB cord-347246-0vofftmj 38 6 have have VBP cord-347246-0vofftmj 38 7 reduced reduce VBN cord-347246-0vofftmj 38 8 food food NN cord-347246-0vofftmj 38 9 consumption consumption NN cord-347246-0vofftmj 38 10 , , , cord-347246-0vofftmj 38 11 weight weight NN cord-347246-0vofftmj 38 12 loss loss NN cord-347246-0vofftmj 38 13 , , , cord-347246-0vofftmj 38 14 and and CC cord-347246-0vofftmj 38 15 reduced reduce VBN cord-347246-0vofftmj 38 16 breeding breeding NN cord-347246-0vofftmj 38 17 performance performance NN cord-347246-0vofftmj 38 18 all all DT cord-347246-0vofftmj 38 19 of of IN cord-347246-0vofftmj 38 20 which which WDT cord-347246-0vofftmj 38 21 can can MD cord-347246-0vofftmj 38 22 affect affect VB cord-347246-0vofftmj 38 23 toxicology toxicology NN cord-347246-0vofftmj 38 24 studies study NNS cord-347246-0vofftmj 38 25 . . . cord-347246-0vofftmj 39 1 The the DT cord-347246-0vofftmj 39 2 interactions interaction NNS cord-347246-0vofftmj 39 3 of of IN cord-347246-0vofftmj 39 4 SDAV SDAV NNP cord-347246-0vofftmj 39 5 with with IN cord-347246-0vofftmj 39 6 other other JJ cord-347246-0vofftmj 39 7 respiratory respiratory JJ cord-347246-0vofftmj 39 8 pathogens pathogen NNS cord-347246-0vofftmj 39 9 and and CC cord-347246-0vofftmj 39 10 chemical chemical NN cord-347246-0vofftmj 39 11 agents agent NNS cord-347246-0vofftmj 39 12 is be VBZ cord-347246-0vofftmj 39 13 not not RB cord-347246-0vofftmj 39 14 well well RB cord-347246-0vofftmj 39 15 established establish VBN cord-347246-0vofftmj 39 16 . . . cord-347246-0vofftmj 40 1 Recent recent JJ cord-347246-0vofftmj 40 2 experimental experimental JJ cord-347246-0vofftmj 40 3 evidence evidence NN cord-347246-0vofftmj 40 4 suggests suggest VBZ cord-347246-0vofftmj 40 5 that that IN cord-347246-0vofftmj 40 6 SDAV SDAV NNP cord-347246-0vofftmj 40 7 infection infection NN cord-347246-0vofftmj 40 8 depletes deplete VBZ cord-347246-0vofftmj 40 9 salivary salivary NN cord-347246-0vofftmj 40 10 epidermal epidermal JJ cord-347246-0vofftmj 40 11 growth growth NN cord-347246-0vofftmj 40 12 factor factor NN cord-347246-0vofftmj 40 13 ( ( -LRB- cord-347246-0vofftmj 40 14 EGF EGF NNP cord-347246-0vofftmj 40 15 ) ) -RRB- cord-347246-0vofftmj 40 16 and and CC cord-347246-0vofftmj 40 17 may may MD cord-347246-0vofftmj 40 18 thereby thereby RB cord-347246-0vofftmj 40 19 affect affect VB cord-347246-0vofftmj 40 20 EGFdependent egfdependent JJ cord-347246-0vofftmj 40 21 cell cell NN cord-347246-0vofftmj 40 22 growth growth NN cord-347246-0vofftmj 40 23 processes process NNS cord-347246-0vofftmj 40 24 and and CC cord-347246-0vofftmj 40 25 experimental experimental JJ cord-347246-0vofftmj 40 26 carcinogenesis carcinogenesis NN cord-347246-0vofftmj 40 27 studies study NNS cord-347246-0vofftmj 40 28 in in IN cord-347246-0vofftmj 40 29 rats rat NNS cord-347246-0vofftmj 40 30 ( ( -LRB- cord-347246-0vofftmj 40 31 8) 8) NNP cord-347246-0vofftmj 40 32 . . . cord-347246-0vofftmj 41 1 Results result NNS cord-347246-0vofftmj 41 2 of of IN cord-347246-0vofftmj 41 3 a a DT cord-347246-0vofftmj 41 4 2-year 2-year CD cord-347246-0vofftmj 41 5 inhalation inhalation NN cord-347246-0vofftmj 41 6 toxicity toxicity NN cord-347246-0vofftmj 41 7 study study NN cord-347246-0vofftmj 41 8 of of IN cord-347246-0vofftmj 41 9 methylene methylene NN cord-347246-0vofftmj 41 10 chloride chloride NN cord-347246-0vofftmj 41 11 were be VBD cord-347246-0vofftmj 41 12 clouded cloud VBN cord-347246-0vofftmj 41 13 by by IN cord-347246-0vofftmj 41 14 SDAV SDAV NNP cord-347246-0vofftmj 41 15 infection infection NN cord-347246-0vofftmj 41 16 of of IN cord-347246-0vofftmj 41 17 rats rat NNS cord-347246-0vofftmj 41 18 early early RB cord-347246-0vofftmj 41 19 in in IN cord-347246-0vofftmj 41 20 the the DT cord-347246-0vofftmj 41 21 study study NN cord-347246-0vofftmj 41 22 ( ( -LRB- cord-347246-0vofftmj 41 23 9 9 CD cord-347246-0vofftmj 41 24 ) ) -RRB- cord-347246-0vofftmj 41 25 . . . cord-347246-0vofftmj 42 1 In in IN cord-347246-0vofftmj 42 2 this this DT cord-347246-0vofftmj 42 3 study study NN cord-347246-0vofftmj 42 4 , , , cord-347246-0vofftmj 42 5 a a DT cord-347246-0vofftmj 42 6 low low JJ cord-347246-0vofftmj 42 7 number number NN cord-347246-0vofftmj 42 8 of of IN cord-347246-0vofftmj 42 9 male male JJ cord-347246-0vofftmj 42 10 rats rat NNS cord-347246-0vofftmj 42 11 exposed expose VBN cord-347246-0vofftmj 42 12 to to IN cord-347246-0vofftmj 42 13 the the DT cord-347246-0vofftmj 42 14 two two CD cord-347246-0vofftmj 42 15 highest high JJS cord-347246-0vofftmj 42 16 doses dose NNS cord-347246-0vofftmj 42 17 of of IN cord-347246-0vofftmj 42 18 the the DT cord-347246-0vofftmj 42 19 chemical chemical NN cord-347246-0vofftmj 42 20 had have VBD cord-347246-0vofftmj 42 21 an an DT cord-347246-0vofftmj 42 22 increased increase VBN cord-347246-0vofftmj 42 23 incidence incidence NN cord-347246-0vofftmj 42 24 of of IN cord-347246-0vofftmj 42 25 sarcomas sarcoma NNS cord-347246-0vofftmj 42 26 in in IN cord-347246-0vofftmj 42 27 the the DT cord-347246-0vofftmj 42 28 ventral ventral JJ cord-347246-0vofftmj 42 29 neck neck NN cord-347246-0vofftmj 42 30 region region NN cord-347246-0vofftmj 42 31 . . . cord-347246-0vofftmj 43 1 The the DT cord-347246-0vofftmj 43 2 relevance relevance NN cord-347246-0vofftmj 43 3 and and CC cord-347246-0vofftmj 43 4 toxicological toxicological JJ cord-347246-0vofftmj 43 5 significance significance NN cord-347246-0vofftmj 43 6 of of IN cord-347246-0vofftmj 43 7 these these DT cord-347246-0vofftmj 43 8 neoplasms neoplasm NNS cord-347246-0vofftmj 43 9 was be VBD cord-347246-0vofftmj 43 10 questionable questionable JJ cord-347246-0vofftmj 43 11 because because IN cord-347246-0vofftmj 43 12 the the DT cord-347246-0vofftmj 43 13 species specie NNS cord-347246-0vofftmj 43 14 and and CC cord-347246-0vofftmj 43 15 sex sex NN cord-347246-0vofftmj 43 16 specificity specificity NN cord-347246-0vofftmj 43 17 of of IN cord-347246-0vofftmj 43 18 the the DT cord-347246-0vofftmj 43 19 response response NN cord-347246-0vofftmj 43 20 was be VBD cord-347246-0vofftmj 43 21 inconsistent inconsistent JJ cord-347246-0vofftmj 43 22 with with IN cord-347246-0vofftmj 43 23 the the DT cord-347246-0vofftmj 43 24 body body NN cord-347246-0vofftmj 43 25 of of IN cord-347246-0vofftmj 43 26 knowledge knowledge NN cord-347246-0vofftmj 43 27 on on IN cord-347246-0vofftmj 43 28 the the DT cord-347246-0vofftmj 43 29 toxicity toxicity NN cord-347246-0vofftmj 43 30 of of IN cord-347246-0vofftmj 43 31 the the DT cord-347246-0vofftmj 43 32 chemical chemical NN cord-347246-0vofftmj 43 33 . . . cord-347246-0vofftmj 44 1 It -PRON- PRP cord-347246-0vofftmj 44 2 was be VBD cord-347246-0vofftmj 44 3 postulated postulate VBN cord-347246-0vofftmj 44 4 that that IN cord-347246-0vofftmj 44 5 the the DT cord-347246-0vofftmj 44 6 tumor tumor NN cord-347246-0vofftmj 44 7 response response NN cord-347246-0vofftmj 44 8 may may MD cord-347246-0vofftmj 44 9 have have VB cord-347246-0vofftmj 44 10 been be VBN cord-347246-0vofftmj 44 11 due due JJ cord-347246-0vofftmj 44 12 to to IN cord-347246-0vofftmj 44 13 a a DT cord-347246-0vofftmj 44 14 combination combination NN cord-347246-0vofftmj 44 15 of of IN cord-347246-0vofftmj 44 16 viral viral JJ cord-347246-0vofftmj 44 17 infection infection NN cord-347246-0vofftmj 44 18 and and CC cord-347246-0vofftmj 44 19 exposure exposure NN cord-347246-0vofftmj 44 20 to to IN cord-347246-0vofftmj 44 21 high high JJ cord-347246-0vofftmj 44 22 concentrations concentration NNS cord-347246-0vofftmj 44 23 of of IN cord-347246-0vofftmj 44 24 methylene methylene NN cord-347246-0vofftmj 44 25 chloride chloride NN cord-347246-0vofftmj 44 26 . . . cord-347246-0vofftmj 45 1 This this DT cord-347246-0vofftmj 45 2 case case NN cord-347246-0vofftmj 45 3 exemplifies exemplify VBZ cord-347246-0vofftmj 45 4 the the DT cord-347246-0vofftmj 45 5 problems problem NNS cord-347246-0vofftmj 45 6 that that WDT cord-347246-0vofftmj 45 7 may may MD cord-347246-0vofftmj 45 8 occur occur VB cord-347246-0vofftmj 45 9 in in IN cord-347246-0vofftmj 45 10 toxicologic toxicologic NNP cord-347246-0vofftmj 45 11 studies study NNS cord-347246-0vofftmj 45 12 when when WRB cord-347246-0vofftmj 45 13 unusual unusual JJ cord-347246-0vofftmj 45 14 and and CC cord-347246-0vofftmj 45 15 unexpected unexpected JJ cord-347246-0vofftmj 45 16 lesions lesion NNS cord-347246-0vofftmj 45 17 are be VBP cord-347246-0vofftmj 45 18 found find VBN cord-347246-0vofftmj 45 19 in in IN cord-347246-0vofftmj 45 20 animals animal NNS cord-347246-0vofftmj 45 21 that that WDT cord-347246-0vofftmj 45 22 had have VBD cord-347246-0vofftmj 45 23 infectious infectious JJ cord-347246-0vofftmj 45 24 processes process NNS cord-347246-0vofftmj 45 25 within within IN cord-347246-0vofftmj 45 26 the the DT cord-347246-0vofftmj 45 27 target target NN cord-347246-0vofftmj 45 28 organ organ NN cord-347246-0vofftmj 45 29 of of IN cord-347246-0vofftmj 45 30 toxicity toxicity NN cord-347246-0vofftmj 45 31 . . . cord-347246-0vofftmj 46 1 Sendai Sendai NNP cord-347246-0vofftmj 46 2 virus virus NN cord-347246-0vofftmj 46 3 is be VBZ cord-347246-0vofftmj 46 4 a a DT cord-347246-0vofftmj 46 5 very very RB cord-347246-0vofftmj 46 6 common common JJ cord-347246-0vofftmj 46 7 respiratory respiratory JJ cord-347246-0vofftmj 46 8 pathogen pathogen NN cord-347246-0vofftmj 46 9 of of IN cord-347246-0vofftmj 46 10 laboratory laboratory NN cord-347246-0vofftmj 46 11 rodents rodent NNS cord-347246-0vofftmj 46 12 that that WDT cord-347246-0vofftmj 46 13 has have VBZ cord-347246-0vofftmj 46 14 complicated complicate VBN cord-347246-0vofftmj 46 15 numerous numerous JJ cord-347246-0vofftmj 46 16 toxicology toxicology NN cord-347246-0vofftmj 46 17 and and CC cord-347246-0vofftmj 46 18 carcinogenicity carcinogenicity NN cord-347246-0vofftmj 46 19 studies study NNS cord-347246-0vofftmj 46 20 ( ( -LRB- cord-347246-0vofftmj 46 21 10 10 CD cord-347246-0vofftmj 46 22 ) ) -RRB- cord-347246-0vofftmj 46 23 . . . cord-347246-0vofftmj 47 1 In in IN cord-347246-0vofftmj 47 2 mice mouse NNS cord-347246-0vofftmj 47 3 and and CC cord-347246-0vofftmj 47 4 rats rat NNS cord-347246-0vofftmj 47 5 , , , cord-347246-0vofftmj 47 6 this this DT cord-347246-0vofftmj 47 7 paramyxovirus paramyxovirus NN cord-347246-0vofftmj 47 8 causes cause VBZ cord-347246-0vofftmj 47 9 clinical clinical JJ cord-347246-0vofftmj 47 10 and and CC cord-347246-0vofftmj 47 11 subclinical subclinical JJ cord-347246-0vofftmj 47 12 changes change NNS cord-347246-0vofftmj 47 13 with with IN cord-347246-0vofftmj 47 14 great great JJ cord-347246-0vofftmj 47 15 strain strain NN cord-347246-0vofftmj 47 16 variability variability NN cord-347246-0vofftmj 47 17 in in IN cord-347246-0vofftmj 47 18 disease disease NN cord-347246-0vofftmj 47 19 expression expression NN cord-347246-0vofftmj 47 20 and and CC cord-347246-0vofftmj 47 21 resultant resultant JJ cord-347246-0vofftmj 47 22 pathologic pathologic JJ cord-347246-0vofftmj 47 23 lesions lesion NNS cord-347246-0vofftmj 47 24 . . . cord-347246-0vofftmj 48 1 The the DT cord-347246-0vofftmj 48 2 virus virus NN cord-347246-0vofftmj 48 3 has have VBZ cord-347246-0vofftmj 48 4 a a DT cord-347246-0vofftmj 48 5 marked marked JJ cord-347246-0vofftmj 48 6 tropism tropism NN cord-347246-0vofftmj 48 7 for for IN cord-347246-0vofftmj 48 8 the the DT cord-347246-0vofftmj 48 9 respiratory respiratory JJ cord-347246-0vofftmj 48 10 tract tract NN cord-347246-0vofftmj 48 11 , , , cord-347246-0vofftmj 48 12 including include VBG cord-347246-0vofftmj 48 13 the the DT cord-347246-0vofftmj 48 14 nasal nasal NN cord-347246-0vofftmj 48 15 cavity cavity NN cord-347246-0vofftmj 48 16 . . . cord-347246-0vofftmj 49 1 Sendai Sendai NNP cord-347246-0vofftmj 49 2 virus virus NN cord-347246-0vofftmj 49 3 infection infection NN cord-347246-0vofftmj 49 4 has have VBZ cord-347246-0vofftmj 49 5 been be VBN cord-347246-0vofftmj 49 6 well well RB cord-347246-0vofftmj 49 7 described describe VBN cord-347246-0vofftmj 49 8 for for IN cord-347246-0vofftmj 49 9 mice mouse NNS cord-347246-0vofftmj 49 10 ( ( -LRB- cord-347246-0vofftmj 49 11 11 11 CD cord-347246-0vofftmj 49 12 ) ) -RRB- cord-347246-0vofftmj 49 13 ( ( -LRB- cord-347246-0vofftmj 49 14 12 12 CD cord-347246-0vofftmj 49 15 ) ) -RRB- cord-347246-0vofftmj 49 16 ( ( -LRB- cord-347246-0vofftmj 49 17 13 13 CD cord-347246-0vofftmj 49 18 ) ) -RRB- cord-347246-0vofftmj 49 19 , , , cord-347246-0vofftmj 49 20 and and CC cord-347246-0vofftmj 49 21 recently recently RB cord-347246-0vofftmj 49 22 the the DT cord-347246-0vofftmj 49 23 course course NN cord-347246-0vofftmj 49 24 of of IN cord-347246-0vofftmj 49 25 experimental experimental JJ cord-347246-0vofftmj 49 26 infection infection NN cord-347246-0vofftmj 49 27 in in IN cord-347246-0vofftmj 49 28 the the DT cord-347246-0vofftmj 49 29 rat rat NN cord-347246-0vofftmj 49 30 has have VBZ cord-347246-0vofftmj 49 31 been be VBN cord-347246-0vofftmj 49 32 reported report VBN cord-347246-0vofftmj 49 33 ( ( -LRB- cord-347246-0vofftmj 49 34 14 14 CD cord-347246-0vofftmj 49 35 ) ) -RRB- cord-347246-0vofftmj 49 36 . . . cord-347246-0vofftmj 50 1 Sendai Sendai NNP cord-347246-0vofftmj 50 2 virus virus NN cord-347246-0vofftmj 50 3 infection infection NN cord-347246-0vofftmj 50 4 causes cause VBZ cord-347246-0vofftmj 50 5 rhinitis rhinitis NN cord-347246-0vofftmj 50 6 , , , cord-347246-0vofftmj 50 7 tracheobronchitis tracheobronchitis NNP cord-347246-0vofftmj 50 8 , , , cord-347246-0vofftmj 50 9 bronchiolitis bronchiolitis NN cord-347246-0vofftmj 50 10 , , , cord-347246-0vofftmj 50 11 and and CC cord-347246-0vofftmj 50 12 varying vary VBG cord-347246-0vofftmj 50 13 degrees degree NNS cord-347246-0vofftmj 50 14 of of IN cord-347246-0vofftmj 50 15 alveolitis alveolitis NN cord-347246-0vofftmj 50 16 in in IN cord-347246-0vofftmj 50 17 both both DT cord-347246-0vofftmj 50 18 rats rat NNS cord-347246-0vofftmj 50 19 and and CC cord-347246-0vofftmj 50 20 mice mouse NNS cord-347246-0vofftmj 50 21 . . . cord-347246-0vofftmj 51 1 There there EX cord-347246-0vofftmj 51 2 is be VBZ cord-347246-0vofftmj 51 3 marked mark VBN cord-347246-0vofftmj 51 4 strain strain NN cord-347246-0vofftmj 51 5 variability variability NN cord-347246-0vofftmj 51 6 in in IN cord-347246-0vofftmj 51 7 qualitative qualitative JJ cord-347246-0vofftmj 51 8 , , , cord-347246-0vofftmj 51 9 quantitative quantitative JJ cord-347246-0vofftmj 51 10 , , , cord-347246-0vofftmj 51 11 and and CC cord-347246-0vofftmj 51 12 chronological chronological JJ cord-347246-0vofftmj 51 13 aspects aspect NNS cord-347246-0vofftmj 51 14 oflesion oflesion NN cord-347246-0vofftmj 51 15 development development NN cord-347246-0vofftmj 51 16 , , , cord-347246-0vofftmj 51 17 which which WDT cord-347246-0vofftmj 51 18 causes cause VBZ cord-347246-0vofftmj 51 19 difficulty difficulty NN cord-347246-0vofftmj 51 20 in in IN cord-347246-0vofftmj 51 21 making make VBG cord-347246-0vofftmj 51 22 generlizations generlization NNS cord-347246-0vofftmj 51 23 regardingthe regardingthe NNP cord-347246-0vofftmj 51 24 pathology pathology NN cord-347246-0vofftmj 51 25 ofthe ofthe DT cord-347246-0vofftmj 51 26 respiratory respiratory JJ cord-347246-0vofftmj 51 27 tract tract NN cord-347246-0vofftmj 51 28 . . . cord-347246-0vofftmj 52 1 Although although IN cord-347246-0vofftmj 52 2 there there EX cord-347246-0vofftmj 52 3 are be VBP cord-347246-0vofftmj 52 4 many many JJ cord-347246-0vofftmj 52 5 excellent excellent JJ cord-347246-0vofftmj 52 6 descriptive descriptive JJ cord-347246-0vofftmj 52 7 studies study NNS cord-347246-0vofftmj 52 8 ofthe ofthe DT cord-347246-0vofftmj 52 9 histogenesis histogenesis NN cord-347246-0vofftmj 52 10 of of IN cord-347246-0vofftmj 52 11 Sendai Sendai NNP cord-347246-0vofftmj 52 12 virus virus NN cord-347246-0vofftmj 52 13 - - HYPH cord-347246-0vofftmj 52 14 induced induce VBN cord-347246-0vofftmj 52 15 lesions lesion NNS cord-347246-0vofftmj 52 16 within within IN cord-347246-0vofftmj 52 17 the the DT cord-347246-0vofftmj 52 18 lower low JJR cord-347246-0vofftmj 52 19 respiratory respiratory JJ cord-347246-0vofftmj 52 20 tract tract NN cord-347246-0vofftmj 52 21 , , , cord-347246-0vofftmj 52 22 few few JJ cord-347246-0vofftmj 52 23 pathology pathology NN cord-347246-0vofftmj 52 24 reports report NNS cord-347246-0vofftmj 52 25 include include VBP cord-347246-0vofftmj 52 26 a a DT cord-347246-0vofftmj 52 27 description description NN cord-347246-0vofftmj 52 28 of of IN cord-347246-0vofftmj 52 29 lesions lesion NNS cord-347246-0vofftmj 52 30 in in IN cord-347246-0vofftmj 52 31 the the DT cord-347246-0vofftmj 52 32 nasal nasal NN cord-347246-0vofftmj 52 33 cavity cavity NN cord-347246-0vofftmj 52 34 and and CC cord-347246-0vofftmj 52 35 upper upper JJ cord-347246-0vofftmj 52 36 airway airway NN cord-347246-0vofftmj 52 37 . . . cord-347246-0vofftmj 53 1 Nasal nasal NN cord-347246-0vofftmj 53 2 lesions lesion NNS cord-347246-0vofftmj 53 3 have have VBP cord-347246-0vofftmj 53 4 been be VBN cord-347246-0vofftmj 53 5 well well RB cord-347246-0vofftmj 53 6 described describe VBN cord-347246-0vofftmj 53 7 in in IN cord-347246-0vofftmj 53 8 experimental experimental JJ cord-347246-0vofftmj 53 9 infections infection NNS cord-347246-0vofftmj 53 10 of of IN cord-347246-0vofftmj 53 11 the the DT cord-347246-0vofftmj 53 12 Sprague Sprague NNP cord-347246-0vofftmj 53 13 - - HYPH cord-347246-0vofftmj 53 14 Dawley Dawley NNP cord-347246-0vofftmj 53 15 rat rat NN cord-347246-0vofftmj 53 16 ( ( -LRB- cord-347246-0vofftmj 53 17 14 14 CD cord-347246-0vofftmj 53 18 ) ) -RRB- cord-347246-0vofftmj 53 19 . . . cord-347246-0vofftmj 54 1 In in IN cord-347246-0vofftmj 54 2 this this DT cord-347246-0vofftmj 54 3 model model NN cord-347246-0vofftmj 54 4 , , , cord-347246-0vofftmj 54 5 a a DT cord-347246-0vofftmj 54 6 rapid rapid JJ cord-347246-0vofftmj 54 7 development development NN cord-347246-0vofftmj 54 8 of of IN cord-347246-0vofftmj 54 9 severe severe JJ cord-347246-0vofftmj 54 10 rhinitis rhinitis NN cord-347246-0vofftmj 54 11 with with IN cord-347246-0vofftmj 54 12 marked marked JJ cord-347246-0vofftmj 54 13 infiltration infiltration NN cord-347246-0vofftmj 54 14 of of IN cord-347246-0vofftmj 54 15 the the DT cord-347246-0vofftmj 54 16 epithelium epithelium NN cord-347246-0vofftmj 54 17 and and CC cord-347246-0vofftmj 54 18 lamina lamina NN cord-347246-0vofftmj 54 19 propria propria FW cord-347246-0vofftmj 54 20 with with IN cord-347246-0vofftmj 54 21 lymphocytes lymphocyte NNS cord-347246-0vofftmj 54 22 and and CC cord-347246-0vofftmj 54 23 some some DT cord-347246-0vofftmj 54 24 neutrophils neutrophil NNS cord-347246-0vofftmj 54 25 occurred occur VBD cord-347246-0vofftmj 54 26 at at IN cord-347246-0vofftmj 54 27 1 1 CD cord-347246-0vofftmj 54 28 day day NN cord-347246-0vofftmj 54 29 postinfection postinfection NN cord-347246-0vofftmj 54 30 . . . cord-347246-0vofftmj 55 1 Lesions lesion NNS cord-347246-0vofftmj 55 2 were be VBD cord-347246-0vofftmj 55 3 most most RBS cord-347246-0vofftmj 55 4 severe severe JJ cord-347246-0vofftmj 55 5 in in IN cord-347246-0vofftmj 55 6 the the DT cord-347246-0vofftmj 55 7 respiratory respiratory JJ cord-347246-0vofftmj 55 8 epithelium epithelium NN cord-347246-0vofftmj 55 9 of of IN cord-347246-0vofftmj 55 10 the the DT cord-347246-0vofftmj 55 11 naso naso NNP cord-347246-0vofftmj 55 12 - - HYPH cord-347246-0vofftmj 55 13 and and CC cord-347246-0vofftmj 55 14 maxilloturbinates maxilloturbinates NNP cord-347246-0vofftmj 55 15 , , , cord-347246-0vofftmj 55 16 compared compare VBN cord-347246-0vofftmj 55 17 to to IN cord-347246-0vofftmj 55 18 minimal minimal JJ cord-347246-0vofftmj 55 19 lesions lesion NNS cord-347246-0vofftmj 55 20 in in IN cord-347246-0vofftmj 55 21 the the DT cord-347246-0vofftmj 55 22 olfactory olfactory JJ cord-347246-0vofftmj 55 23 epithelium epithelium NN cord-347246-0vofftmj 55 24 of of IN cord-347246-0vofftmj 55 25 the the DT cord-347246-0vofftmj 55 26 ethmoid ethmoid NNP cord-347246-0vofftmj 55 27 region region NN cord-347246-0vofftmj 55 28 . . . cord-347246-0vofftmj 56 1 Over over IN cord-347246-0vofftmj 56 2 the the DT cord-347246-0vofftmj 56 3 next next JJ cord-347246-0vofftmj 56 4 4 4 CD cord-347246-0vofftmj 56 5 days day NNS cord-347246-0vofftmj 56 6 postinfection postinfection NN cord-347246-0vofftmj 56 7 , , , cord-347246-0vofftmj 56 8 there there EX cord-347246-0vofftmj 56 9 was be VBD cord-347246-0vofftmj 56 10 a a DT cord-347246-0vofftmj 56 11 progressive progressive JJ cord-347246-0vofftmj 56 12 accumulation accumulation NN cord-347246-0vofftmj 56 13 of of IN cord-347246-0vofftmj 56 14 inflammatory inflammatory JJ cord-347246-0vofftmj 56 15 cells cell NNS cord-347246-0vofftmj 56 16 , , , cord-347246-0vofftmj 56 17 chiefly chiefly RB cord-347246-0vofftmj 56 18 of of IN cord-347246-0vofftmj 56 19 lymphocytes lymphocyte NNS cord-347246-0vofftmj 56 20 , , , cord-347246-0vofftmj 56 21 in in IN cord-347246-0vofftmj 56 22 the the DT cord-347246-0vofftmj 56 23 lamina lamina JJ cord-347246-0vofftmj 56 24 propria propria NN cord-347246-0vofftmj 56 25 . . . cord-347246-0vofftmj 57 1 The the DT cord-347246-0vofftmj 57 2 lesions lesion NNS cord-347246-0vofftmj 57 3 expanded expand VBD cord-347246-0vofftmj 57 4 to to TO cord-347246-0vofftmj 57 5 involve involve VB cord-347246-0vofftmj 57 6 the the DT cord-347246-0vofftmj 57 7 middle middle JJ cord-347246-0vofftmj 57 8 portions portion NNS cord-347246-0vofftmj 57 9 of of IN cord-347246-0vofftmj 57 10 the the DT cord-347246-0vofftmj 57 11 nasal nasal NN cord-347246-0vofftmj 57 12 septum septum NN cord-347246-0vofftmj 57 13 . . . cord-347246-0vofftmj 58 1 Respiratory respiratory JJ cord-347246-0vofftmj 58 2 epithelial epithelial JJ cord-347246-0vofftmj 58 3 cells cell NNS cord-347246-0vofftmj 58 4 exhibited exhibit VBD cord-347246-0vofftmj 58 5 pyknosis pyknosis NNP cord-347246-0vofftmj 58 6 and and CC cord-347246-0vofftmj 58 7 karyorrhexis karyorrhexis NNP cord-347246-0vofftmj 58 8 , , , cord-347246-0vofftmj 58 9 particularly particularly RB cord-347246-0vofftmj 58 10 in in IN cord-347246-0vofftmj 58 11 the the DT cord-347246-0vofftmj 58 12 more more RBR cord-347246-0vofftmj 58 13 basilar basilar JJ cord-347246-0vofftmj 58 14 regions region NNS cord-347246-0vofftmj 58 15 of of IN cord-347246-0vofftmj 58 16 the the DT cord-347246-0vofftmj 58 17 mucosa mucosa NN cord-347246-0vofftmj 58 18 . . . cord-347246-0vofftmj 59 1 Exudate Exudate NNP cord-347246-0vofftmj 59 2 was be VBD cord-347246-0vofftmj 59 3 noted note VBN cord-347246-0vofftmj 59 4 in in IN cord-347246-0vofftmj 59 5 the the DT cord-347246-0vofftmj 59 6 ethmoid ethmoid NNP cord-347246-0vofftmj 59 7 region region NN cord-347246-0vofftmj 59 8 , , , cord-347246-0vofftmj 59 9 although although IN cord-347246-0vofftmj 59 10 there there EX cord-347246-0vofftmj 59 11 was be VBD cord-347246-0vofftmj 59 12 little little JJ cord-347246-0vofftmj 59 13 inflammation inflammation NN cord-347246-0vofftmj 59 14 in in IN cord-347246-0vofftmj 59 15 that that DT cord-347246-0vofftmj 59 16 area area NN cord-347246-0vofftmj 59 17 . . . cord-347246-0vofftmj 60 1 Between between IN cord-347246-0vofftmj 60 2 5 5 CD cord-347246-0vofftmj 60 3 and and CC cord-347246-0vofftmj 60 4 21 21 CD cord-347246-0vofftmj 60 5 days day NNS cord-347246-0vofftmj 60 6 postinfection postinfection NN cord-347246-0vofftmj 60 7 , , , cord-347246-0vofftmj 60 8 the the DT cord-347246-0vofftmj 60 9 severity severity NN cord-347246-0vofftmj 60 10 of of IN cord-347246-0vofftmj 60 11 the the DT cord-347246-0vofftmj 60 12 nasal nasal JJ cord-347246-0vofftmj 60 13 epithelial epithelial JJ cord-347246-0vofftmj 60 14 necrosis necrosis NN cord-347246-0vofftmj 60 15 , , , cord-347246-0vofftmj 60 16 inflammatory inflammatory JJ cord-347246-0vofftmj 60 17 cell cell NN cord-347246-0vofftmj 60 18 infiltrate infiltrate NN cord-347246-0vofftmj 60 19 , , , cord-347246-0vofftmj 60 20 and and CC cord-347246-0vofftmj 60 21 lumenal lumenal JJ cord-347246-0vofftmj 60 22 exudate exudate NN cord-347246-0vofftmj 60 23 decreased decrease VBD cord-347246-0vofftmj 60 24 . . . cord-347246-0vofftmj 61 1 By by IN cord-347246-0vofftmj 61 2 day day NN cord-347246-0vofftmj 61 3 28 28 CD cord-347246-0vofftmj 61 4 postinfection postinfection NN cord-347246-0vofftmj 61 5 , , , cord-347246-0vofftmj 61 6 no no DT cord-347246-0vofftmj 61 7 discernable discernable JJ cord-347246-0vofftmj 61 8 lesions lesion NNS cord-347246-0vofftmj 61 9 were be VBD cord-347246-0vofftmj 61 10 noted note VBN cord-347246-0vofftmj 61 11 in in IN cord-347246-0vofftmj 61 12 experimentally experimentally RB cord-347246-0vofftmj 61 13 infected infect VBN cord-347246-0vofftmj 61 14 rats rat NNS cord-347246-0vofftmj 61 15 . . . cord-347246-0vofftmj 62 1 There there EX cord-347246-0vofftmj 62 2 are be VBP cord-347246-0vofftmj 62 3 numerous numerous JJ cord-347246-0vofftmj 62 4 systemic systemic JJ cord-347246-0vofftmj 62 5 effects effect NNS cord-347246-0vofftmj 62 6 ( ( -LRB- cord-347246-0vofftmj 62 7 Thble Thble NNP cord-347246-0vofftmj 62 8 1 1 CD cord-347246-0vofftmj 62 9 ) ) -RRB- cord-347246-0vofftmj 62 10 that that IN cord-347246-0vofftmj 62 11 toxicologists toxicologist NNS cord-347246-0vofftmj 62 12 and and CC cord-347246-0vofftmj 62 13 pathologists pathologist NNS cord-347246-0vofftmj 62 14 need need VBP cord-347246-0vofftmj 62 15 to to TO cord-347246-0vofftmj 62 16 consider consider VB cord-347246-0vofftmj 62 17 when when WRB cord-347246-0vofftmj 62 18 interpreting interpret VBG cord-347246-0vofftmj 62 19 the the DT cord-347246-0vofftmj 62 20 impact impact NN cord-347246-0vofftmj 62 21 of of IN cord-347246-0vofftmj 62 22 Sendai Sendai NNP cord-347246-0vofftmj 62 23 virus virus NN cord-347246-0vofftmj 62 24 infection infection NN cord-347246-0vofftmj 62 25 upon upon IN cord-347246-0vofftmj 62 26 study study NN cord-347246-0vofftmj 62 27 results result NNS cord-347246-0vofftmj 62 28 ( ( -LRB- cord-347246-0vofftmj 62 29 10 10 CD cord-347246-0vofftmj 62 30 , , , cord-347246-0vofftmj 62 31 15 15 CD cord-347246-0vofftmj 62 32 ) ) -RRB- cord-347246-0vofftmj 62 33 . . . cord-347246-0vofftmj 63 1 Studies study NNS cord-347246-0vofftmj 63 2 can can MD cord-347246-0vofftmj 63 3 be be VB cord-347246-0vofftmj 63 4 compromised compromise VBN cord-347246-0vofftmj 63 5 through through IN cord-347246-0vofftmj 63 6 reduction reduction NN cord-347246-0vofftmj 63 7 in in IN cord-347246-0vofftmj 63 8 animal animal NN cord-347246-0vofftmj 63 9 numbers number NNS cord-347246-0vofftmj 63 10 , , , cord-347246-0vofftmj 63 11 changes change NNS cord-347246-0vofftmj 63 12 in in IN cord-347246-0vofftmj 63 13 immune immune JJ cord-347246-0vofftmj 63 14 function function NN cord-347246-0vofftmj 63 15 , , , cord-347246-0vofftmj 63 16 xenobiotic xenobiotic JJ cord-347246-0vofftmj 63 17 metabolism metabolism NN cord-347246-0vofftmj 63 18 , , , cord-347246-0vofftmj 63 19 and and CC cord-347246-0vofftmj 63 20 physiology physiology NN cord-347246-0vofftmj 63 21 ( ( -LRB- cord-347246-0vofftmj 63 22 10 10 CD cord-347246-0vofftmj 63 23 ) ) -RRB- cord-347246-0vofftmj 63 24 . . . cord-347246-0vofftmj 64 1 Sendai Sendai NNP cord-347246-0vofftmj 64 2 virus virus NN cord-347246-0vofftmj 64 3 infection infection NN cord-347246-0vofftmj 64 4 has have VBZ cord-347246-0vofftmj 64 5 altered alter VBN cord-347246-0vofftmj 64 6 the the DT cord-347246-0vofftmj 64 7 course course NN cord-347246-0vofftmj 64 8 of of IN cord-347246-0vofftmj 64 9 chemically chemically RB cord-347246-0vofftmj 64 10 induced induce VBN cord-347246-0vofftmj 64 11 pulmonary pulmonary JJ cord-347246-0vofftmj 64 12 carcinogenesis carcinogenesis NN cord-347246-0vofftmj 64 13 in in IN cord-347246-0vofftmj 64 14 strain strain NN cord-347246-0vofftmj 64 15 A a DT cord-347246-0vofftmj 64 16 mice mice NN cord-347246-0vofftmj 64 17 by by IN cord-347246-0vofftmj 64 18 reducing reduce VBG cord-347246-0vofftmj 64 19 the the DT cord-347246-0vofftmj 64 20 number number NN cord-347246-0vofftmj 64 21 of of IN cord-347246-0vofftmj 64 22 resultant resultant JJ cord-347246-0vofftmj 64 23 lung lung NN cord-347246-0vofftmj 64 24 tumors tumor NNS cord-347246-0vofftmj 64 25 ( ( -LRB- cord-347246-0vofftmj 64 26 16 16 CD cord-347246-0vofftmj 64 27 ) ) -RRB- cord-347246-0vofftmj 64 28 . . . cord-347246-0vofftmj 65 1 In in IN cord-347246-0vofftmj 65 2 addition addition NN cord-347246-0vofftmj 65 3 , , , cord-347246-0vofftmj 65 4 the the DT cord-347246-0vofftmj 65 5 pulmonary pulmonary JJ cord-347246-0vofftmj 65 6 carcinogenic carcinogenic JJ cord-347246-0vofftmj 65 7 responses response NNS cord-347246-0vofftmj 65 8 have have VBP cord-347246-0vofftmj 65 9 been be VBN cord-347246-0vofftmj 65 10 altered alter VBN cord-347246-0vofftmj 65 11 in in IN cord-347246-0vofftmj 65 12 Sendai Sendai NNP cord-347246-0vofftmj 65 13 virus virus NN cord-347246-0vofftmj 65 14 infected infect VBN cord-347246-0vofftmj 65 15 Balb Balb NNP cord-347246-0vofftmj 65 16 / / SYM cord-347246-0vofftmj 65 17 c c NN cord-347246-0vofftmj 65 18 mice mouse NNS cord-347246-0vofftmj 65 19 following follow VBG cord-347246-0vofftmj 65 20 exposure exposure NN cord-347246-0vofftmj 65 21 to to IN cord-347246-0vofftmj 65 22 urethane urethane NN cord-347246-0vofftmj 65 23 ( ( -LRB- cord-347246-0vofftmj 65 24 17 17 CD cord-347246-0vofftmj 65 25 _SP cord-347246-0vofftmj 65 26 Murine Murine NNP cord-347246-0vofftmj 65 27 respiratory respiratory JJ cord-347246-0vofftmj 65 28 mycoplasmosis mycoplasmosis NN cord-347246-0vofftmj 65 29 ( ( -LRB- cord-347246-0vofftmj 65 30 MRM MRM NNP cord-347246-0vofftmj 65 31 ) ) -RRB- cord-347246-0vofftmj 65 32 , , , cord-347246-0vofftmj 65 33 due due IN cord-347246-0vofftmj 65 34 to to IN cord-347246-0vofftmj 65 35 Mycoplasrna Mycoplasrna NNP cord-347246-0vofftmj 65 36 pulmonis pulmonis NNP cord-347246-0vofftmj 65 37 is be VBZ cord-347246-0vofftmj 65 38 a a DT cord-347246-0vofftmj 65 39 naturally naturally RB cord-347246-0vofftmj 65 40 occurring occur VBG cord-347246-0vofftmj 65 41 , , , cord-347246-0vofftmj 65 42 slowly slowly RB cord-347246-0vofftmj 65 43 progressing progress VBG cord-347246-0vofftmj 65 44 , , , cord-347246-0vofftmj 65 45 chronic chronic JJ cord-347246-0vofftmj 65 46 disease disease NN cord-347246-0vofftmj 65 47 in in IN cord-347246-0vofftmj 65 48 rats rat NNS cord-347246-0vofftmj 65 49 and and CC cord-347246-0vofftmj 65 50 mice mouse NNS cord-347246-0vofftmj 65 51 . . . cord-347246-0vofftmj 66 1 Numerous numerous JJ cord-347246-0vofftmj 66 2 respiratory respiratory JJ cord-347246-0vofftmj 66 3 responses response NNS cord-347246-0vofftmj 66 4 are be VBP cord-347246-0vofftmj 66 5 associated associate VBN cord-347246-0vofftmj 66 6 with with IN cord-347246-0vofftmj 66 7 M. M. NNP cord-347246-0vofftmj 66 8 pulmonis pulmonis JJ cord-347246-0vofftmj 66 9 infection infection NN cord-347246-0vofftmj 66 10 of of IN cord-347246-0vofftmj 66 11 rodents rodent NNS cord-347246-0vofftmj 66 12 ( ( -LRB- cord-347246-0vofftmj 66 13 Table table NN cord-347246-0vofftmj 66 14 2 2 CD cord-347246-0vofftmj 66 15 ) ) -RRB- cord-347246-0vofftmj 66 16 ( ( -LRB- cord-347246-0vofftmj 66 17 18 18 CD cord-347246-0vofftmj 66 18 ) ) -RRB- cord-347246-0vofftmj 66 19 . . . cord-347246-0vofftmj 67 1 The the DT cord-347246-0vofftmj 67 2 prevalence prevalence NN cord-347246-0vofftmj 67 3 of of IN cord-347246-0vofftmj 67 4 the the DT cord-347246-0vofftmj 67 5 pathogen pathogen NN cord-347246-0vofftmj 67 6 and and CC cord-347246-0vofftmj 67 7 the the DT cord-347246-0vofftmj 67 8 numerous numerous JJ cord-347246-0vofftmj 67 9 respiratory respiratory JJ cord-347246-0vofftmj 67 10 and and CC cord-347246-0vofftmj 67 11 systemic systemic JJ cord-347246-0vofftmj 67 12 effects effect NNS cord-347246-0vofftmj 67 13 of of IN cord-347246-0vofftmj 67 14 infection infection NN cord-347246-0vofftmj 67 15 make make VBP cord-347246-0vofftmj 67 16 this this DT cord-347246-0vofftmj 67 17 disease disease NN cord-347246-0vofftmj 67 18 one one CD cord-347246-0vofftmj 67 19 of of IN cord-347246-0vofftmj 67 20 the the DT cord-347246-0vofftmj 67 21 most most RBS cord-347246-0vofftmj 67 22 important important JJ cord-347246-0vofftmj 67 23 entities entity NNS cord-347246-0vofftmj 67 24 for for IN cord-347246-0vofftmj 67 25 pathologists pathologist NNS cord-347246-0vofftmj 67 26 and and CC cord-347246-0vofftmj 67 27 toxicologists toxicologist NNS cord-347246-0vofftmj 67 28 during during IN cord-347246-0vofftmj 67 29 studies study NNS cord-347246-0vofftmj 67 30 of of IN cord-347246-0vofftmj 67 31 the the DT cord-347246-0vofftmj 67 32 respiratory respiratory JJ cord-347246-0vofftmj 67 33 tract tract NN cord-347246-0vofftmj 67 34 . . . cord-347246-0vofftmj 68 1 Respiratory respiratory JJ cord-347246-0vofftmj 68 2 mycoplasmosis mycoplasmosis NN cord-347246-0vofftmj 68 3 is be VBZ cord-347246-0vofftmj 68 4 often often RB cord-347246-0vofftmj 68 5 clinically clinically RB cord-347246-0vofftmj 68 6 silent silent JJ cord-347246-0vofftmj 68 7 , , , cord-347246-0vofftmj 68 8 although although IN cord-347246-0vofftmj 68 9 lesions lesion NNS cord-347246-0vofftmj 68 10 of of IN cord-347246-0vofftmj 68 11 the the DT cord-347246-0vofftmj 68 12 upper upper JJ cord-347246-0vofftmj 68 13 respiratory respiratory JJ cord-347246-0vofftmj 68 14 tract tract NN cord-347246-0vofftmj 68 15 commonly commonly RB cord-347246-0vofftmj 68 16 occur occur VBP cord-347246-0vofftmj 68 17 ( ( -LRB- cord-347246-0vofftmj 68 18 19 19 CD cord-347246-0vofftmj 68 19 ) ) -RRB- cord-347246-0vofftmj 68 20 . . . cord-347246-0vofftmj 69 1 The the DT cord-347246-0vofftmj 69 2 principal principal JJ cord-347246-0vofftmj 69 3 lesions lesion NNS cord-347246-0vofftmj 69 4 of of IN cord-347246-0vofftmj 69 5 MRM MRM NNP cord-347246-0vofftmj 69 6 in in IN cord-347246-0vofftmj 69 7 rats rat NNS cord-347246-0vofftmj 69 8 include include VBP cord-347246-0vofftmj 69 9 rhinitis rhinitis NN cord-347246-0vofftmj 69 10 , , , cord-347246-0vofftmj 69 11 otitis otitis NN cord-347246-0vofftmj 69 12 media medium NNS cord-347246-0vofftmj 69 13 , , , cord-347246-0vofftmj 69 14 laryngitis laryngitis NN cord-347246-0vofftmj 69 15 , , , cord-347246-0vofftmj 69 16 and and CC cord-347246-0vofftmj 69 17 tracheitis tracheitis NNP cord-347246-0vofftmj 69 18 ( ( -LRB- cord-347246-0vofftmj 69 19 20 20 CD cord-347246-0vofftmj 69 20 ) ) -RRB- cord-347246-0vofftmj 69 21 . . . cord-347246-0vofftmj 70 1 Gross gross JJ cord-347246-0vofftmj 70 2 lesions lesion NNS cord-347246-0vofftmj 70 3 in in IN cord-347246-0vofftmj 70 4 the the DT cord-347246-0vofftmj 70 5 upper upper JJ cord-347246-0vofftmj 70 6 respiratory respiratory JJ cord-347246-0vofftmj 70 7 tract tract NN cord-347246-0vofftmj 70 8 are be VBP cord-347246-0vofftmj 70 9 generally generally RB cord-347246-0vofftmj 70 10 not not RB cord-347246-0vofftmj 70 11 discernable discernable JJ cord-347246-0vofftmj 70 12 , , , cord-347246-0vofftmj 70 13 although although IN cord-347246-0vofftmj 70 14 rats rat NNS cord-347246-0vofftmj 70 15 may may MD cord-347246-0vofftmj 70 16 occasionally occasionally RB cord-347246-0vofftmj 70 17 show show VB cord-347246-0vofftmj 70 18 mucopurulent mucopurulent NN cord-347246-0vofftmj 70 19 nasal nasal NN cord-347246-0vofftmj 70 20 exudate exudate NN cord-347246-0vofftmj 70 21 and/or and/or CC cord-347246-0vofftmj 70 22 porphyrin porphyrin NN cord-347246-0vofftmj 70 23 - - HYPH cord-347246-0vofftmj 70 24 tinted tint VBN cord-347246-0vofftmj 70 25 oculonasal oculonasal NN cord-347246-0vofftmj 70 26 discharge discharge NN cord-347246-0vofftmj 70 27 . . . cord-347246-0vofftmj 71 1 The the DT cord-347246-0vofftmj 71 2 microscopic microscopic JJ cord-347246-0vofftmj 71 3 pathology pathology NN cord-347246-0vofftmj 71 4 of of IN cord-347246-0vofftmj 71 5 MRM MRM NNP cord-347246-0vofftmj 71 6 is be VBZ cord-347246-0vofftmj 71 7 characterized characterize VBN cord-347246-0vofftmj 71 8 by by IN cord-347246-0vofftmj 71 9 epithelial epithelial JJ cord-347246-0vofftmj 71 10 changes change NNS cord-347246-0vofftmj 71 11 including include VBG cord-347246-0vofftmj 71 12 cellular cellular JJ cord-347246-0vofftmj 71 13 hypertrophy hypertrophy NN cord-347246-0vofftmj 71 14 and and CC cord-347246-0vofftmj 71 15 hyperplasia hyperplasia NN cord-347246-0vofftmj 71 16 , , , cord-347246-0vofftmj 71 17 as as RB cord-347246-0vofftmj 71 18 well well RB cord-347246-0vofftmj 71 19 as as IN cord-347246-0vofftmj 71 20 metaplastic metaplastic JJ cord-347246-0vofftmj 71 21 changes change NNS cord-347246-0vofftmj 71 22 . . . cord-347246-0vofftmj 72 1 Neutrophilic Neutrophilic NNP cord-347246-0vofftmj 72 2 exudation exudation NN cord-347246-0vofftmj 72 3 and and CC cord-347246-0vofftmj 72 4 lymphoplasmacytic lymphoplasmacytic NN cord-347246-0vofftmj 72 5 infiltrates infiltrate NNS cord-347246-0vofftmj 72 6 are be VBP cord-347246-0vofftmj 72 7 common common JJ cord-347246-0vofftmj 72 8 throughout throughout IN cord-347246-0vofftmj 72 9 the the DT cord-347246-0vofftmj 72 10 upper upper JJ cord-347246-0vofftmj 72 11 airway airway NN cord-347246-0vofftmj 72 12 . . . cord-347246-0vofftmj 73 1 Subepithelial subepithelial JJ cord-347246-0vofftmj 73 2 lymphoid lymphoid JJ cord-347246-0vofftmj 73 3 accumulations accumulation NNS cord-347246-0vofftmj 73 4 can can MD cord-347246-0vofftmj 73 5 occur occur VB cord-347246-0vofftmj 73 6 in in IN cord-347246-0vofftmj 73 7 MRM MRM NNP cord-347246-0vofftmj 73 8 - - HYPH cord-347246-0vofftmj 73 9 associated associate VBN cord-347246-0vofftmj 73 10 rhinitis rhinitis NN cord-347246-0vofftmj 73 11 ( ( -LRB- cord-347246-0vofftmj 73 12 Plates plate NNS cord-347246-0vofftmj 73 13 1 1 CD cord-347246-0vofftmj 73 14 and and CC cord-347246-0vofftmj 73 15 2 2 CD cord-347246-0vofftmj 73 16 ) ) -RRB- cord-347246-0vofftmj 73 17 . . . cord-347246-0vofftmj 74 1 Ciliary ciliary JJ cord-347246-0vofftmj 74 2 loss loss NN cord-347246-0vofftmj 74 3 and and CC cord-347246-0vofftmj 74 4 epithelial epithelial JJ cord-347246-0vofftmj 74 5 hyperplasias hyperplasias NNP cord-347246-0vofftmj 74 6 can can MD cord-347246-0vofftmj 74 7 be be VB cord-347246-0vofftmj 74 8 severe severe JJ cord-347246-0vofftmj 74 9 and and CC cord-347246-0vofftmj 74 10 quite quite RB cord-347246-0vofftmj 74 11 extensive extensive JJ cord-347246-0vofftmj 74 12 . . . cord-347246-0vofftmj 75 1 The the DT cord-347246-0vofftmj 75 2 relative relative JJ cord-347246-0vofftmj 75 3 importance importance NN cord-347246-0vofftmj 75 4 of of IN cord-347246-0vofftmj 75 5 direct direct JJ cord-347246-0vofftmj 75 6 mycoplasmal mycoplasmal JJ cord-347246-0vofftmj 75 7 damage damage NN cord-347246-0vofftmj 75 8 , , , cord-347246-0vofftmj 75 9 as as IN cord-347246-0vofftmj 75 10 opposed oppose VBN cord-347246-0vofftmj 75 11 to to IN cord-347246-0vofftmj 75 12 immune immune JJ cord-347246-0vofftmj 75 13 and and CC cord-347246-0vofftmj 75 14 nonimmune nonimmune JJ cord-347246-0vofftmj 75 15 inflammatory inflammatory JJ cord-347246-0vofftmj 75 16 reactions reaction NNS cord-347246-0vofftmj 75 17 forM. form. POS cord-347246-0vofftmj 75 18 pulmonwn pulmonwn NN cord-347246-0vofftmj 75 19 has have VBZ cord-347246-0vofftmj 75 20 yet yet RB cord-347246-0vofftmj 75 21 to to TO cord-347246-0vofftmj 75 22 be be VB cord-347246-0vofftmj 75 23 completely completely RB cord-347246-0vofftmj 75 24 discerned discern VBN cord-347246-0vofftmj 75 25 ( ( -LRB- cord-347246-0vofftmj 75 26 19 19 CD cord-347246-0vofftmj 75 27 ) ) -RRB- cord-347246-0vofftmj 75 28 . . . cord-347246-0vofftmj 76 1 It -PRON- PRP cord-347246-0vofftmj 76 2 is be VBZ cord-347246-0vofftmj 76 3 known know VBN cord-347246-0vofftmj 76 4 that that IN cord-347246-0vofftmj 76 5 cytolysis cytolysis NNP cord-347246-0vofftmj 76 6 follows follow VBZ cord-347246-0vofftmj 76 7 attachment attachment NN cord-347246-0vofftmj 76 8 of of IN cord-347246-0vofftmj 76 9 M. M. NNP cord-347246-0vofftmj 76 10 pulmonis pulmonis NNP cord-347246-0vofftmj 76 11 to to IN cord-347246-0vofftmj 76 12 upper upper JJ cord-347246-0vofftmj 76 13 airway airway NN cord-347246-0vofftmj 76 14 epithelial epithelial JJ cord-347246-0vofftmj 76 15 cells cell NNS cord-347246-0vofftmj 76 16 . . . cord-347246-0vofftmj 77 1 Ciliastasis Ciliastasis NNP cord-347246-0vofftmj 77 2 , , , cord-347246-0vofftmj 77 3 loss loss NN cord-347246-0vofftmj 77 4 of of IN cord-347246-0vofftmj 77 5 cilia cilia NN cord-347246-0vofftmj 77 6 , , , cord-347246-0vofftmj 77 7 distension distension NN cord-347246-0vofftmj 77 8 of of IN cord-347246-0vofftmj 77 9 intercellular intercellular JJ cord-347246-0vofftmj 77 10 spaces space NNS cord-347246-0vofftmj 77 11 , , , cord-347246-0vofftmj 77 12 cytoplasmic cytoplasmic JJ cord-347246-0vofftmj 77 13 vacuolization vacuolization NN cord-347246-0vofftmj 77 14 , , , cord-347246-0vofftmj 77 15 disruption disruption NN cord-347246-0vofftmj 77 16 of of IN cord-347246-0vofftmj 77 17 mitochondria mitochondrion NNS cord-347246-0vofftmj 77 18 , , , cord-347246-0vofftmj 77 19 epithelial epithelial JJ cord-347246-0vofftmj 77 20 hyperplasia hyperplasia NN cord-347246-0vofftmj 77 21 and and CC cord-347246-0vofftmj 77 22 metaplasia metaplasia NN cord-347246-0vofftmj 77 23 , , , cord-347246-0vofftmj 77 24 and and CC cord-347246-0vofftmj 77 25 syncytial syncytial JJ cord-347246-0vofftmj 77 26 cell cell NN cord-347246-0vofftmj 77 27 formation formation NN cord-347246-0vofftmj 77 28 have have VBP cord-347246-0vofftmj 77 29 also also RB cord-347246-0vofftmj 77 30 resulted result VBN cord-347246-0vofftmj 77 31 following follow VBG cord-347246-0vofftmj 77 32 attachment attachment NN cord-347246-0vofftmj 77 33 of of IN cord-347246-0vofftmj 77 34 this this DT cord-347246-0vofftmj 77 35 organism organism NN cord-347246-0vofftmj 77 36 ( ( -LRB- cord-347246-0vofftmj 77 37 19 19 CD cord-347246-0vofftmj 77 38 ) ) -RRB- cord-347246-0vofftmj 77 39 . . . cord-347246-0vofftmj 78 1 The the DT cord-347246-0vofftmj 78 2 tympanic tympanic JJ cord-347246-0vofftmj 78 3 cavity cavity NN cord-347246-0vofftmj 78 4 of of IN cord-347246-0vofftmj 78 5 the the DT cord-347246-0vofftmj 78 6 ear ear NN cord-347246-0vofftmj 78 7 may may MD cord-347246-0vofftmj 78 8 be be VB cord-347246-0vofftmj 78 9 completely completely RB cord-347246-0vofftmj 78 10 filled fill VBN cord-347246-0vofftmj 78 11 with with IN cord-347246-0vofftmj 78 12 a a DT cord-347246-0vofftmj 78 13 neutrophilic neutrophilic JJ cord-347246-0vofftmj 78 14 exudate exudate NN cord-347246-0vofftmj 78 15 . . . cord-347246-0vofftmj 79 1 Frequently frequently RB cord-347246-0vofftmj 79 2 in in IN cord-347246-0vofftmj 79 3 MRMinduced mrminduce VBN cord-347246-0vofftmj 79 4 otitis otitis NN cord-347246-0vofftmj 79 5 media medium NNS cord-347246-0vofftmj 79 6 , , , cord-347246-0vofftmj 79 7 the the DT cord-347246-0vofftmj 79 8 lining lining NN cord-347246-0vofftmj 79 9 epithelium epithelium NN cord-347246-0vofftmj 79 10 is be VBZ cord-347246-0vofftmj 79 11 hyperplastic hyperplastic JJ cord-347246-0vofftmj 79 12 and and CC cord-347246-0vofftmj 79 13 the the DT cord-347246-0vofftmj 79 14 lumenal lumenal JJ cord-347246-0vofftmj 79 15 cavity cavity NN cord-347246-0vofftmj 79 16 may may MD cord-347246-0vofftmj 79 17 become become VB cord-347246-0vofftmj 79 18 filled fill VBN cord-347246-0vofftmj 79 19 with with IN cord-347246-0vofftmj 79 20 collagenous collagenous JJ cord-347246-0vofftmj 79 21 connective connective JJ cord-347246-0vofftmj 79 22 tissue tissue NN cord-347246-0vofftmj 79 23 . . . cord-347246-0vofftmj 80 1 Thickened thickened JJ cord-347246-0vofftmj 80 2 connective connective JJ cord-347246-0vofftmj 80 3 tissue tissue NN cord-347246-0vofftmj 80 4 lining line VBG cord-347246-0vofftmj 80 5 the the DT cord-347246-0vofftmj 80 6 tympanic tympanic JJ cord-347246-0vofftmj 80 7 cavity cavity NN cord-347246-0vofftmj 80 8 may may MD cord-347246-0vofftmj 80 9 remain remain VB cord-347246-0vofftmj 80 10 as as IN cord-347246-0vofftmj 80 11 a a DT cord-347246-0vofftmj 80 12 chronic chronic JJ cord-347246-0vofftmj 80 13 sequellum sequellum NN cord-347246-0vofftmj 80 14 of of IN cord-347246-0vofftmj 80 15 the the DT cord-347246-0vofftmj 80 16 infection infection NN cord-347246-0vofftmj 80 17 . . . cord-347246-0vofftmj 81 1 Epithelial epithelial JJ cord-347246-0vofftmj 81 2 hyperplasias hyperplasias NN cord-347246-0vofftmj 81 3 and and CC cord-347246-0vofftmj 81 4 lymphoid lymphoid JJ cord-347246-0vofftmj 81 5 cell cell NN cord-347246-0vofftmj 81 6 accumulations accumulation NNS cord-347246-0vofftmj 81 7 are be VBP cord-347246-0vofftmj 81 8 commonly commonly RB cord-347246-0vofftmj 81 9 found find VBN cord-347246-0vofftmj 81 10 in in IN cord-347246-0vofftmj 81 11 the the DT cord-347246-0vofftmj 81 12 Certain certain JJ cord-347246-0vofftmj 81 13 chemical chemical JJ cord-347246-0vofftmj 81 14 agents agent NNS cord-347246-0vofftmj 81 15 , , , cord-347246-0vofftmj 81 16 including include VBG cord-347246-0vofftmj 81 17 ammonia ammonia NN cord-347246-0vofftmj 81 18 , , , cord-347246-0vofftmj 81 19 which which WDT cord-347246-0vofftmj 81 20 is be VBZ cord-347246-0vofftmj 81 21 commonly commonly RB cord-347246-0vofftmj 81 22 found find VBN cord-347246-0vofftmj 81 23 in in IN cord-347246-0vofftmj 81 24 the the DT cord-347246-0vofftmj 81 25 cage cage NN cord-347246-0vofftmj 81 26 environment environment NN cord-347246-0vofftmj 81 27 from from IN cord-347246-0vofftmj 81 28 soiled soiled JJ cord-347246-0vofftmj 81 29 bedding bedding NN cord-347246-0vofftmj 81 30 , , , cord-347246-0vofftmj 81 31 can can MD cord-347246-0vofftmj 81 32 exacerbate exacerbate VB cord-347246-0vofftmj 81 33 MRM MRM NNP cord-347246-0vofftmj 81 34 in in IN cord-347246-0vofftmj 81 35 rats rat NNS cord-347246-0vofftmj 81 36 . . . cord-347246-0vofftmj 82 1 Inhalation inhalation NN cord-347246-0vofftmj 82 2 of of IN cord-347246-0vofftmj 82 3 the the DT cord-347246-0vofftmj 82 4 important important JJ cord-347246-0vofftmj 82 5 industrial industrial JJ cord-347246-0vofftmj 82 6 compound compound NN cord-347246-0vofftmj 82 7 hexamethylphosphoramide hexamethylphosphoramide NN cord-347246-0vofftmj 82 8 ( ( -LRB- cord-347246-0vofftmj 82 9 HMPA HMPA NNP cord-347246-0vofftmj 82 10 ) ) -RRB- cord-347246-0vofftmj 82 11 can can MD cord-347246-0vofftmj 82 12 cause cause VB cord-347246-0vofftmj 82 13 a a DT cord-347246-0vofftmj 82 14 synergistic synergistic JJ cord-347246-0vofftmj 82 15 enhancement enhancement NN cord-347246-0vofftmj 82 16 of of IN cord-347246-0vofftmj 82 17 the the DT cord-347246-0vofftmj 82 18 progression progression NN cord-347246-0vofftmj 82 19 and and CC cord-347246-0vofftmj 82 20 severity severity NN cord-347246-0vofftmj 82 21 of of IN cord-347246-0vofftmj 82 22 MRM MRM NNP cord-347246-0vofftmj 82 23 ( ( -LRB- cord-347246-0vofftmj 82 24 21 21 CD cord-347246-0vofftmj 82 25 , , , cord-347246-0vofftmj 82 26 22 22 CD cord-347246-0vofftmj 82 27 ) ) -RRB- cord-347246-0vofftmj 82 28 . . . cord-347246-0vofftmj 83 1 In in IN cord-347246-0vofftmj 83 2 HMPA HMPA NNP cord-347246-0vofftmj 83 3 toxicity toxicity NN cord-347246-0vofftmj 83 4 studies study NNS cord-347246-0vofftmj 83 5 , , , cord-347246-0vofftmj 83 6 nasal nasal JJ cord-347246-0vofftmj 83 7 tumors tumor NNS cord-347246-0vofftmj 83 8 , , , cord-347246-0vofftmj 83 9 rhinitis rhinitis NN cord-347246-0vofftmj 83 10 , , , cord-347246-0vofftmj 83 11 nasal nasal JJ cord-347246-0vofftmj 83 12 epithelial epithelial JJ cord-347246-0vofftmj 83 13 degeneration degeneration NN cord-347246-0vofftmj 83 14 , , , cord-347246-0vofftmj 83 15 metaplasia metaplasia NN cord-347246-0vofftmj 83 16 , , , cord-347246-0vofftmj 83 17 and and CC cord-347246-0vofftmj 83 18 dysplasia dysplasia NN cord-347246-0vofftmj 83 19 were be VBD cord-347246-0vofftmj 83 20 noted note VBN cord-347246-0vofftmj 83 21 in in IN cord-347246-0vofftmj 83 22 cornunction cornunction NN cord-347246-0vofftmj 83 23 with with IN cord-347246-0vofftmj 83 24 an an DT cord-347246-0vofftmj 83 25 enhanced enhanced JJ cord-347246-0vofftmj 83 26 mortality mortality NN cord-347246-0vofftmj 83 27 from from IN cord-347246-0vofftmj 83 28 chronic chronic JJ cord-347246-0vofftmj 83 29 pneumonia pneumonia NN cord-347246-0vofftmj 83 30 in in IN cord-347246-0vofftmj 83 31 infected infected JJ cord-347246-0vofftmj 83 32 rats rat NNS cord-347246-0vofftmj 83 33 . . . cord-347246-0vofftmj 84 1 The the DT cord-347246-0vofftmj 84 2 increased increased JJ cord-347246-0vofftmj 84 3 mortality mortality NN cord-347246-0vofftmj 84 4 was be VBD cord-347246-0vofftmj 84 5 possibly possibly RB cord-347246-0vofftmj 84 6 due due JJ cord-347246-0vofftmj 84 7 to to IN cord-347246-0vofftmj 84 8 a a DT cord-347246-0vofftmj 84 9 chemically chemically RB cord-347246-0vofftmj 84 10 induced induce VBN cord-347246-0vofftmj 84 11 destruction destruction NN cord-347246-0vofftmj 84 12 of of IN cord-347246-0vofftmj 84 13 the the DT cord-347246-0vofftmj 84 14 mucociliary mucociliary JJ cord-347246-0vofftmj 84 15 apparatus apparatus NN cord-347246-0vofftmj 84 16 in in IN cord-347246-0vofftmj 84 17 the the DT cord-347246-0vofftmj 84 18 upper upper JJ cord-347246-0vofftmj 84 19 airway airway NN cord-347246-0vofftmj 84 20 , , , cord-347246-0vofftmj 84 21 which which WDT cord-347246-0vofftmj 84 22 may may MD cord-347246-0vofftmj 84 23 have have VB cord-347246-0vofftmj 84 24 contributed contribute VBN cord-347246-0vofftmj 84 25 to to TO cord-347246-0vofftmj 84 26 fatal fatal JJ cord-347246-0vofftmj 84 27 lower low JJR cord-347246-0vofftmj 84 28 respiratory respiratory JJ cord-347246-0vofftmj 84 29 infections infection NNS cord-347246-0vofftmj 84 30 . . . cord-347246-0vofftmj 85 1 A a DT cord-347246-0vofftmj 85 2 chronic chronic JJ cord-347246-0vofftmj 85 3 inhalation inhalation NN cord-347246-0vofftmj 85 4 bioassay bioassay NN cord-347246-0vofftmj 85 5 of of IN cord-347246-0vofftmj 85 6 propylene propylene NN cord-347246-0vofftmj 85 7 oxide oxide NN cord-347246-0vofftmj 85 8 revealed reveal VBD cord-347246-0vofftmj 85 9 dose dose NN cord-347246-0vofftmj 85 10 - - HYPH cord-347246-0vofftmj 85 11 dependent dependent JJ cord-347246-0vofftmj 85 12 nasal nasal NN cord-347246-0vofftmj 85 13 epithelial epithelial JJ cord-347246-0vofftmj 85 14 proliferative proliferative JJ cord-347246-0vofftmj 85 15 lesions lesion NNS cord-347246-0vofftmj 85 16 and and CC cord-347246-0vofftmj 85 17 two two CD cord-347246-0vofftmj 85 18 nasal nasal NN cord-347246-0vofftmj 85 19 adenomas adenoma NNS cord-347246-0vofftmj 85 20 in in IN cord-347246-0vofftmj 85 21 rats rat NNS cord-347246-0vofftmj 85 22 with with IN cord-347246-0vofftmj 85 23 intercurrent intercurrent NN cord-347246-0vofftmj 85 24 MRM MRM NNP cord-347246-0vofftmj 85 25 ( ( -LRB- cord-347246-0vofftmj 85 26 23 23 CD cord-347246-0vofftmj 85 27 ) ) -RRB- cord-347246-0vofftmj 85 28 . . . cord-347246-0vofftmj 86 1 The the DT cord-347246-0vofftmj 86 2 significance significance NN cord-347246-0vofftmj 86 3 of of IN cord-347246-0vofftmj 86 4 the the DT cord-347246-0vofftmj 86 5 proliferative proliferative JJ cord-347246-0vofftmj 86 6 nasal nasal NN cord-347246-0vofftmj 86 7 lesions lesion NNS cord-347246-0vofftmj 86 8 , , , cord-347246-0vofftmj 86 9 which which WDT cord-347246-0vofftmj 86 10 appeared appear VBD cord-347246-0vofftmj 86 11 to to TO cord-347246-0vofftmj 86 12 be be VB cord-347246-0vofftmj 86 13 treatment treatment NN cord-347246-0vofftmj 86 14 related relate VBN cord-347246-0vofftmj 86 15 , , , cord-347246-0vofftmj 86 16 was be VBD cord-347246-0vofftmj 86 17 difficult difficult JJ cord-347246-0vofftmj 86 18 to to TO cord-347246-0vofftmj 86 19 interpret interpret VB cord-347246-0vofftmj 86 20 , , , cord-347246-0vofftmj 86 21 since since IN cord-347246-0vofftmj 86 22 their -PRON- PRP$ cord-347246-0vofftmj 86 23 development development NN cord-347246-0vofftmj 86 24 may may MD cord-347246-0vofftmj 86 25 have have VB cord-347246-0vofftmj 86 26 been be VBN cord-347246-0vofftmj 86 27 influenced influence VBN cord-347246-0vofftmj 86 28 by by IN cord-347246-0vofftmj 86 29 intercurrent intercurrent NN cord-347246-0vofftmj 86 30 infectious infectious JJ cord-347246-0vofftmj 86 31 inflammatory inflammatory JJ cord-347246-0vofftmj 86 32 disease disease NN cord-347246-0vofftmj 86 33 . . . cord-347246-0vofftmj 87 1 Although although IN cord-347246-0vofftmj 87 2 numerous numerous JJ cord-347246-0vofftmj 87 3 bacteria bacteria NNS cord-347246-0vofftmj 87 4 can can MD cord-347246-0vofftmj 87 5 infect infect VB cord-347246-0vofftmj 87 6 the the DT cord-347246-0vofftmj 87 7 upper upper JJ cord-347246-0vofftmj 87 8 airway airway NN cord-347246-0vofftmj 87 9 of of IN cord-347246-0vofftmj 87 10 the the DT cord-347246-0vofftmj 87 11 rat rat NN cord-347246-0vofftmj 87 12 and and CC cord-347246-0vofftmj 87 13 mouse mouse NN cord-347246-0vofftmj 87 14 , , , cord-347246-0vofftmj 87 15 they -PRON- PRP cord-347246-0vofftmj 87 16 are be VBP cord-347246-0vofftmj 87 17 not not RB cord-347246-0vofftmj 87 18 generally generally RB cord-347246-0vofftmj 87 19 prevalent prevalent JJ cord-347246-0vofftmj 87 20 in in IN cord-347246-0vofftmj 87 21 well well RB cord-347246-0vofftmj 87 22 - - HYPH cord-347246-0vofftmj 87 23 conducted conduct VBN cord-347246-0vofftmj 87 24 toxicology toxicology NN cord-347246-0vofftmj 87 25 studies study NNS cord-347246-0vofftmj 87 26 begun begin VBN cord-347246-0vofftmj 87 27 with with IN cord-347246-0vofftmj 87 28 animals animal NNS cord-347246-0vofftmj 87 29 free free JJ cord-347246-0vofftmj 87 30 of of IN cord-347246-0vofftmj 87 31 adventitious adventitious JJ cord-347246-0vofftmj 87 32 murine murine JJ cord-347246-0vofftmj 87 33 pathogens pathogen NNS cord-347246-0vofftmj 87 34 and and CC cord-347246-0vofftmj 87 35 maintained maintain VBN cord-347246-0vofftmj 87 36 with with IN cord-347246-0vofftmj 87 37 modern modern JJ cord-347246-0vofftmj 87 38 methods method NNS cord-347246-0vofftmj 87 39 of of IN cord-347246-0vofftmj 87 40 laboratory laboratory NN cord-347246-0vofftmj 87 41 animal animal NN cord-347246-0vofftmj 87 42 husbandry husbandry NN cord-347246-0vofftmj 87 43 . . . cord-347246-0vofftmj 88 1 However however RB cord-347246-0vofftmj 88 2 , , , cord-347246-0vofftmj 88 3 the the DT cord-347246-0vofftmj 88 4 cilia cilia NN cord-347246-0vofftmj 88 5 - - HYPH cord-347246-0vofftmj 88 6 associated associate VBN cord-347246-0vofftmj 88 7 respiratory respiratory NN cord-347246-0vofftmj 88 8 ( ( -LRB- cord-347246-0vofftmj 88 9 CAR car NN cord-347246-0vofftmj 88 10 ) ) -RRB- cord-347246-0vofftmj 88 11 bacillus bacillus NN cord-347246-0vofftmj 88 12 has have VBZ cord-347246-0vofftmj 88 13 recently recently RB cord-347246-0vofftmj 88 14 received receive VBN cord-347246-0vofftmj 88 15 attention attention NN cord-347246-0vofftmj 88 16 . . . cord-347246-0vofftmj 89 1 This this DT cord-347246-0vofftmj 89 2 gramnegative gramnegative NN cord-347246-0vofftmj 89 3 , , , cord-347246-0vofftmj 89 4 filamentous filamentous JJ cord-347246-0vofftmj 89 5 , , , cord-347246-0vofftmj 89 6 rod rod NN cord-347246-0vofftmj 89 7 - - HYPH cord-347246-0vofftmj 89 8 shaped shape VBN cord-347246-0vofftmj 89 9 bacillus bacillus NN cord-347246-0vofftmj 89 10 ( ( -LRB- cord-347246-0vofftmj 89 11 24 24 CD cord-347246-0vofftmj 89 12 , , , cord-347246-0vofftmj 89 13 25 25 CD cord-347246-0vofftmj 89 14 ) ) -RRB- cord-347246-0vofftmj 89 15 infects infect VBZ cord-347246-0vofftmj 89 16 both both DT cord-347246-0vofftmj 89 17 rats rat NNS cord-347246-0vofftmj 89 18 and and CC cord-347246-0vofftmj 89 19 mice mouse NNS cord-347246-0vofftmj 89 20 and and CC cord-347246-0vofftmj 89 21 causes cause VBZ cord-347246-0vofftmj 89 22 lesions lesion NNS cord-347246-0vofftmj 89 23 morphologically morphologically RB cord-347246-0vofftmj 89 24 similar similar JJ cord-347246-0vofftmj 89 25 to to IN cord-347246-0vofftmj 89 26 those those DT cord-347246-0vofftmj 89 27 of of IN cord-347246-0vofftmj 89 28 M. M. NNP cord-347246-0vofftmj 89 29 pulmonis pulmonis NNP cord-347246-0vofftmj 89 30 infections infection NNS cord-347246-0vofftmj 89 31 . . . cord-347246-0vofftmj 90 1 The the DT cord-347246-0vofftmj 90 2 CAR car NN cord-347246-0vofftmj 90 3 bacillus bacillus NN cord-347246-0vofftmj 90 4 was be VBD cord-347246-0vofftmj 90 5 generally generally RB cord-347246-0vofftmj 90 6 overlooked overlook VBN cord-347246-0vofftmj 90 7 in in IN cord-347246-0vofftmj 90 8 the the DT cord-347246-0vofftmj 90 9 past past NN cord-347246-0vofftmj 90 10 because because IN cord-347246-0vofftmj 90 11 it -PRON- PRP cord-347246-0vofftmj 90 12 often often RB cord-347246-0vofftmj 90 13 occurred occur VBD cord-347246-0vofftmj 90 14 as as IN cord-347246-0vofftmj 90 15 a a DT cord-347246-0vofftmj 90 16 dual dual JJ cord-347246-0vofftmj 90 17 infection infection NN cord-347246-0vofftmj 90 18 with with IN cord-347246-0vofftmj 90 19 M. M. NNP cord-347246-0vofftmj 90 20 pulmonis pulmonis NNP cord-347246-0vofftmj 90 21 . . . cord-347246-0vofftmj 91 1 Lesions lesion NNS cord-347246-0vofftmj 91 2 typical typical JJ cord-347246-0vofftmj 91 3 of of IN cord-347246-0vofftmj 91 4 mycoplasmal mycoplasmal JJ cord-347246-0vofftmj 91 5 chronic chronic JJ cord-347246-0vofftmj 91 6 respiratory respiratory JJ cord-347246-0vofftmj 91 7 disease disease NN cord-347246-0vofftmj 91 8 have have VBP cord-347246-0vofftmj 91 9 been be VBN cord-347246-0vofftmj 91 10 noted note VBN cord-347246-0vofftmj 91 11 following follow VBG cord-347246-0vofftmj 91 12 natural natural JJ cord-347246-0vofftmj 91 13 and and CC cord-347246-0vofftmj 91 14 experimental experimental JJ cord-347246-0vofftmj 91 15 infection infection NN cord-347246-0vofftmj 91 16 with with IN cord-347246-0vofftmj 91 17 the the DT cord-347246-0vofftmj 91 18 CAR car NN cord-347246-0vofftmj 91 19 bacillus bacillus NN cord-347246-0vofftmj 91 20 . . . cord-347246-0vofftmj 92 1 These these DT cord-347246-0vofftmj 92 2 lesions lesion NNS cord-347246-0vofftmj 92 3 include include VBP cord-347246-0vofftmj 92 4 massive massive JJ cord-347246-0vofftmj 92 5 accumulations accumulation NNS cord-347246-0vofftmj 92 6 of of IN cord-347246-0vofftmj 92 7 predominantly predominantly RB cord-347246-0vofftmj 92 8 mononuclear mononuclear JJ cord-347246-0vofftmj 92 9 inflammatory inflammatory JJ cord-347246-0vofftmj 92 10 cells cell NNS cord-347246-0vofftmj 92 11 surrounding surround VBG cord-347246-0vofftmj 92 12 bronchi bronchi NN cord-347246-0vofftmj 92 13 and and CC cord-347246-0vofftmj 92 14 bronchioles bronchiole NNS cord-347246-0vofftmj 92 15 ( ( -LRB- cord-347246-0vofftmj 92 16 Plate plate NN cord-347246-0vofftmj 92 17 3 3 CD cord-347246-0vofftmj 92 18 ) ) -RRB- cord-347246-0vofftmj 92 19 , , , cord-347246-0vofftmj 92 20 as as RB cord-347246-0vofftmj 92 21 well well RB cord-347246-0vofftmj 92 22 as as IN cord-347246-0vofftmj 92 23 various various JJ cord-347246-0vofftmj 92 24 degrees degree NNS cord-347246-0vofftmj 92 25 of of IN cord-347246-0vofftmj 92 26 suppurative suppurative JJ cord-347246-0vofftmj 92 27 bronchopneumonia bronchopneumonia NN cord-347246-0vofftmj 92 28 , , , cord-347246-0vofftmj 92 29 squamous squamous JJ cord-347246-0vofftmj 92 30 metaplasia metaplasia NN cord-347246-0vofftmj 92 31 , , , cord-347246-0vofftmj 92 32 and and CC cord-347246-0vofftmj 92 33 bronchiectasis bronchiectasis NN cord-347246-0vofftmj 92 34 . . . cord-347246-0vofftmj 93 1 The the DT cord-347246-0vofftmj 93 2 ciliated ciliated JJ cord-347246-0vofftmj 93 3 epithelium epithelium NN cord-347246-0vofftmj 93 4 of of IN cord-347246-0vofftmj 93 5 the the DT cord-347246-0vofftmj 93 6 airway airway NN cord-347246-0vofftmj 93 7 is be VBZ cord-347246-0vofftmj 93 8 usually usually RB cord-347246-0vofftmj 93 9 heavily heavily RB cord-347246-0vofftmj 93 10 colonized colonize VBN cord-347246-0vofftmj 93 11 with with IN cord-347246-0vofftmj 93 12 filamentous filamentous JJ cord-347246-0vofftmj 93 13 bacteria bacteria NNS cord-347246-0vofftmj 93 14 , , , cord-347246-0vofftmj 93 15 which which WDT cord-347246-0vofftmj 93 16 can can MD cord-347246-0vofftmj 93 17 be be VB cord-347246-0vofftmj 93 18 readily readily RB cord-347246-0vofftmj 93 19 demonstrated demonstrate VBN cord-347246-0vofftmj 93 20 with with IN cord-347246-0vofftmj 93 21 Warthin Warthin NNP cord-347246-0vofftmj 93 22 - - HYPH cord-347246-0vofftmj 93 23 Starry Starry NNP cord-347246-0vofftmj 93 24 silver silver NN cord-347246-0vofftmj 93 25 impregnation impregnation NN cord-347246-0vofftmj 93 26 techniques technique NNS cord-347246-0vofftmj 93 27 ( ( -LRB- cord-347246-0vofftmj 93 28 Plate plate NN cord-347246-0vofftmj 93 29 4 4 CD cord-347246-0vofftmj 93 30 ) ) -RRB- cord-347246-0vofftmj 93 31 . . . cord-347246-0vofftmj 94 1 Little little JJ cord-347246-0vofftmj 94 2 is be VBZ cord-347246-0vofftmj 94 3 known know VBN cord-347246-0vofftmj 94 4 regarding regard VBG cord-347246-0vofftmj 94 5 the the DT cord-347246-0vofftmj 94 6 prevalence prevalence NN cord-347246-0vofftmj 94 7 of of IN cord-347246-0vofftmj 94 8 this this DT cord-347246-0vofftmj 94 9 organism organism NN cord-347246-0vofftmj 94 10 as as IN cord-347246-0vofftmj 94 11 a a DT cord-347246-0vofftmj 94 12 subclinical subclinical JJ cord-347246-0vofftmj 94 13 infection infection NN cord-347246-0vofftmj 94 14 . . . cord-347246-0vofftmj 95 1 Although although IN cord-347246-0vofftmj 95 2 lesions lesion NNS cord-347246-0vofftmj 95 3 induced induce VBN cord-347246-0vofftmj 95 4 by by IN cord-347246-0vofftmj 95 5 the the DT cord-347246-0vofftmj 95 6 CAR car NN cord-347246-0vofftmj 95 7 bacillus bacillus NN cord-347246-0vofftmj 95 8 have have VBP cord-347246-0vofftmj 95 9 been be VBN cord-347246-0vofftmj 95 10 described describe VBN cord-347246-0vofftmj 95 11 in in IN cord-347246-0vofftmj 95 12 the the DT cord-347246-0vofftmj 95 13 lungs lung NNS cord-347246-0vofftmj 95 14 of of IN cord-347246-0vofftmj 95 15 both both DT cord-347246-0vofftmj 95 16 rats rat NNS cord-347246-0vofftmj 95 17 and and CC cord-347246-0vofftmj 95 18 mice mouse NNS cord-347246-0vofftmj 95 19 , , , cord-347246-0vofftmj 95 20 there there EX cord-347246-0vofftmj 95 21 have have VBP cord-347246-0vofftmj 95 22 been be VBN cord-347246-0vofftmj 95 23 no no DT cord-347246-0vofftmj 95 24 descriptions description NNS cord-347246-0vofftmj 95 25 of of IN cord-347246-0vofftmj 95 26 pathology pathology NN cord-347246-0vofftmj 95 27 in in IN cord-347246-0vofftmj 95 28 the the DT cord-347246-0vofftmj 95 29 upper upper JJ cord-347246-0vofftmj 95 30 airway airway NN cord-347246-0vofftmj 95 31 where where WRB cord-347246-0vofftmj 95 32 , , , cord-347246-0vofftmj 95 33 presumably presumably RB cord-347246-0vofftmj 95 34 , , , cord-347246-0vofftmj 95 35 the the DT cord-347246-0vofftmj 95 36 organism organism NN cord-347246-0vofftmj 95 37 can can MD cord-347246-0vofftmj 95 38 also also RB cord-347246-0vofftmj 95 39 grow grow VB cord-347246-0vofftmj 95 40 . . . cord-347246-0vofftmj 96 1 Elucidation elucidation NN cord-347246-0vofftmj 96 2 of of IN cord-347246-0vofftmj 96 3 the the DT cord-347246-0vofftmj 96 4 significance significance NN cord-347246-0vofftmj 96 5 of of IN cord-347246-0vofftmj 96 6 this this DT cord-347246-0vofftmj 96 7 pathogen pathogen NN cord-347246-0vofftmj 96 8 for for IN cord-347246-0vofftmj 96 9 rodent rodent NN cord-347246-0vofftmj 96 10 toxicity toxicity NN cord-347246-0vofftmj 96 11 awaits await VBZ cord-347246-0vofftmj 96 12 further further JJ cord-347246-0vofftmj 96 13 studies study NNS cord-347246-0vofftmj 96 14 and and CC cord-347246-0vofftmj 96 15 characterization characterization NN cord-347246-0vofftmj 96 16 . . . cord-347246-0vofftmj 97 1 Descriptions description NNS cord-347246-0vofftmj 97 2 of of IN cord-347246-0vofftmj 97 3 naturally naturally RB cord-347246-0vofftmj 97 4 occurring occur VBG cord-347246-0vofftmj 97 5 fungal fungal JJ cord-347246-0vofftmj 97 6 infections infection NNS cord-347246-0vofftmj 97 7 of of IN cord-347246-0vofftmj 97 8 the the DT cord-347246-0vofftmj 97 9 respiratory respiratory JJ cord-347246-0vofftmj 97 10 tract tract NN cord-347246-0vofftmj 97 11 of of IN cord-347246-0vofftmj 97 12 rodents rodent NNS cord-347246-0vofftmj 97 13 are be VBP cord-347246-0vofftmj 97 14 extremely extremely RB cord-347246-0vofftmj 97 15 rare rare JJ cord-347246-0vofftmj 97 16 . . . cord-347246-0vofftmj 98 1 The the DT cord-347246-0vofftmj 98 2 histological histological JJ cord-347246-0vofftmj 98 3 features feature NNS cord-347246-0vofftmj 98 4 of of IN cord-347246-0vofftmj 98 5 fungal fungal JJ cord-347246-0vofftmj 98 6 rhinitis rhinitis NN cord-347246-0vofftmj 98 7 , , , cord-347246-0vofftmj 98 8 which which WDT cord-347246-0vofftmj 98 9 occurred occur VBD cord-347246-0vofftmj 98 10 in in IN cord-347246-0vofftmj 98 11 high high JJ cord-347246-0vofftmj 98 12 incidence incidence NN cord-347246-0vofftmj 98 13 in in IN cord-347246-0vofftmj 98 14 two two CD cord-347246-0vofftmj 98 15 separate separate JJ cord-347246-0vofftmj 98 16 chronic chronic JJ cord-347246-0vofftmj 98 17 carcinogenicity carcinogenicity NN cord-347246-0vofftmj 98 18 studies study NNS cord-347246-0vofftmj 98 19 in in IN cord-347246-0vofftmj 98 20 male male JJ cord-347246-0vofftmj 98 21 Wistar Wistar NNP cord-347246-0vofftmj 98 22 rats rat NNS cord-347246-0vofftmj 98 23 ( ( -LRB- cord-347246-0vofftmj 98 24 129/597 129/597 CD cord-347246-0vofftmj 98 25 animals animal NNS cord-347246-0vofftmj 98 26 ) ) -RRB- cord-347246-0vofftmj 98 27 , , , cord-347246-0vofftmj 98 28 have have VBP cord-347246-0vofftmj 98 29 been be VBN cord-347246-0vofftmj 98 30 described describe VBN cord-347246-0vofftmj 98 31 ( ( -LRB- cord-347246-0vofftmj 98 32 26 26 CD cord-347246-0vofftmj 98 33 ) ) -RRB- cord-347246-0vofftmj 98 34 . . . cord-347246-0vofftmj 99 1 Since since IN cord-347246-0vofftmj 99 2 these these DT cord-347246-0vofftmj 99 3 animals animal NNS cord-347246-0vofftmj 99 4 had have VBD cord-347246-0vofftmj 99 5 titers titer NNS cord-347246-0vofftmj 99 6 to to IN cord-347246-0vofftmj 99 7 both both CC cord-347246-0vofftmj 99 8 Sendai Sendai NNP cord-347246-0vofftmj 99 9 and and CC cord-347246-0vofftmj 99 10 SDAV SDAV NNP cord-347246-0vofftmj 99 11 viruses virus NNS cord-347246-0vofftmj 99 12 , , , cord-347246-0vofftmj 99 13 the the DT cord-347246-0vofftmj 99 14 authors author NNS cord-347246-0vofftmj 99 15 suggested suggest VBD cord-347246-0vofftmj 99 16 that that IN cord-347246-0vofftmj 99 17 viral viral RB cord-347246-0vofftmj 99 18 - - HYPH cord-347246-0vofftmj 99 19 induced induce VBN cord-347246-0vofftmj 99 20 inflammation inflammation NN cord-347246-0vofftmj 99 21 of of IN cord-347246-0vofftmj 99 22 the the DT cord-347246-0vofftmj 99 23 upper upper JJ cord-347246-0vofftmj 99 24 respiratory respiratory JJ cord-347246-0vofftmj 99 25 mucosa mucosa NN cord-347246-0vofftmj 99 26 rendered render VBD cord-347246-0vofftmj 99 27 the the DT cord-347246-0vofftmj 99 28 epithelium epithelium NN cord-347246-0vofftmj 99 29 susceptible susceptible JJ cord-347246-0vofftmj 99 30 to to IN cord-347246-0vofftmj 99 31 the the DT cord-347246-0vofftmj 99 32 fungal fungal JJ cord-347246-0vofftmj 99 33 infection infection NN cord-347246-0vofftmj 99 34 . . . cord-347246-0vofftmj 100 1 In in IN cord-347246-0vofftmj 100 2 addition addition NN cord-347246-0vofftmj 100 3 to to IN cord-347246-0vofftmj 100 4 the the DT cord-347246-0vofftmj 100 5 129 129 CD cord-347246-0vofftmj 100 6 animals animal NNS cord-347246-0vofftmj 100 7 with with IN cord-347246-0vofftmj 100 8 fungal fungal JJ cord-347246-0vofftmj 100 9 infection infection NN cord-347246-0vofftmj 100 10 , , , cord-347246-0vofftmj 100 11 80 80 CD cord-347246-0vofftmj 100 12 animals animal NNS cord-347246-0vofftmj 100 13 had have VBD cord-347246-0vofftmj 100 14 suppurative suppurative JJ cord-347246-0vofftmj 100 15 rhinitis rhinitis NN cord-347246-0vofftmj 100 16 without without IN cord-347246-0vofftmj 100 17 evident evident JJ cord-347246-0vofftmj 100 18 fungal fungal JJ cord-347246-0vofftmj 100 19 growth growth NN cord-347246-0vofftmj 100 20 . . . cord-347246-0vofftmj 101 1 An an DT cord-347246-0vofftmj 101 2 etiologic etiologic JJ cord-347246-0vofftmj 101 3 diagnosis diagnosis NN cord-347246-0vofftmj 101 4 ofAspergillusfumigatus ofAspergillusfumigatus NNP cord-347246-0vofftmj 101 5 was be VBD cord-347246-0vofftmj 101 6 based base VBN cord-347246-0vofftmj 101 7 upon upon IN cord-347246-0vofftmj 101 8 characteristic characteristic JJ cord-347246-0vofftmj 101 9 morphology morphology NN cord-347246-0vofftmj 101 10 of of IN cord-347246-0vofftmj 101 11 the the DT cord-347246-0vofftmj 101 12 fruiting fruit VBG cord-347246-0vofftmj 101 13 heads head NNS cord-347246-0vofftmj 101 14 found find VBN cord-347246-0vofftmj 101 15 in in IN cord-347246-0vofftmj 101 16 a a DT cord-347246-0vofftmj 101 17 small small JJ cord-347246-0vofftmj 101 18 percentage percentage NN cord-347246-0vofftmj 101 19 of of IN cord-347246-0vofftmj 101 20 cases case NNS cord-347246-0vofftmj 101 21 . . . cord-347246-0vofftmj 102 1 Aspergillus aspergillus NN cord-347246-0vofftmj 102 2 rhinitis rhinitis NN cord-347246-0vofftmj 102 3 was be VBD cord-347246-0vofftmj 102 4 generally generally RB cord-347246-0vofftmj 102 5 noninvasive noninvasive JJ cord-347246-0vofftmj 102 6 and and CC cord-347246-0vofftmj 102 7 limited limited JJ cord-347246-0vofftmj 102 8 to to IN cord-347246-0vofftmj 102 9 the the DT cord-347246-0vofftmj 102 10 naso naso NNP cord-347246-0vofftmj 102 11 - - HYPH cord-347246-0vofftmj 102 12 and and CC cord-347246-0vofftmj 102 13 maxilloturbinates maxilloturbinate NNS cord-347246-0vofftmj 102 14 . . . cord-347246-0vofftmj 103 1 Although although IN cord-347246-0vofftmj 103 2 purulent purulent JJ cord-347246-0vofftmj 103 3 inflammation inflammation NN cord-347246-0vofftmj 103 4 was be VBD cord-347246-0vofftmj 103 5 noted note VBN cord-347246-0vofftmj 103 6 in in IN cord-347246-0vofftmj 103 7 the the DT cord-347246-0vofftmj 103 8 olfactory olfactory JJ cord-347246-0vofftmj 103 9 epithelium epithelium NN cord-347246-0vofftmj 103 10 of of IN cord-347246-0vofftmj 103 11 some some DT cord-347246-0vofftmj 103 12 cases case NNS cord-347246-0vofftmj 103 13 , , , cord-347246-0vofftmj 103 14 fungal fungal JJ cord-347246-0vofftmj 103 15 growth growth NN cord-347246-0vofftmj 103 16 was be VBD cord-347246-0vofftmj 103 17 rarely rarely RB cord-347246-0vofftmj 103 18 noted note VBN cord-347246-0vofftmj 103 19 in in IN cord-347246-0vofftmj 103 20 this this DT cord-347246-0vofftmj 103 21 region region NN cord-347246-0vofftmj 103 22 . . . cord-347246-0vofftmj 104 1 Hyphal Hyphal NNP cord-347246-0vofftmj 104 2 conglomerates conglomerate NNS cord-347246-0vofftmj 104 3 were be VBD cord-347246-0vofftmj 104 4 usually usually RB cord-347246-0vofftmj 104 5 associated associate VBN cord-347246-0vofftmj 104 6 with with IN cord-347246-0vofftmj 104 7 foreign foreign JJ cord-347246-0vofftmj 104 8 bodies body NNS cord-347246-0vofftmj 104 9 ( ( -LRB- cord-347246-0vofftmj 104 10 hair hair NN cord-347246-0vofftmj 104 11 and and CC cord-347246-0vofftmj 104 12 plant plant NN cord-347246-0vofftmj 104 13 material material NN cord-347246-0vofftmj 104 14 ) ) -RRB- cord-347246-0vofftmj 104 15 and and CC cord-347246-0vofftmj 104 16 were be VBD cord-347246-0vofftmj 104 17 surrounded surround VBN cord-347246-0vofftmj 104 18 by by IN cord-347246-0vofftmj 104 19 polymorphonuclear polymorphonuclear JJ cord-347246-0vofftmj 104 20 leukocytes leukocyte NNS cord-347246-0vofftmj 104 21 , , , cord-347246-0vofftmj 104 22 bacteria bacteria NNS cord-347246-0vofftmj 104 23 , , , cord-347246-0vofftmj 104 24 debris debris NN cord-347246-0vofftmj 104 25 , , , cord-347246-0vofftmj 104 26 and and CC cord-347246-0vofftmj 104 27 nasal nasal NN cord-347246-0vofftmj 104 28 secretions secretion NNS cord-347246-0vofftmj 104 29 . . . cord-347246-0vofftmj 105 1 The the DT cord-347246-0vofftmj 105 2 underlying underlying JJ cord-347246-0vofftmj 105 3 respiratory respiratory JJ cord-347246-0vofftmj 105 4 epithelium epithelium NN cord-347246-0vofftmj 105 5 was be VBD cord-347246-0vofftmj 105 6 usually usually RB cord-347246-0vofftmj 105 7 hyperplastic hyperplastic JJ cord-347246-0vofftmj 105 8 , , , cord-347246-0vofftmj 105 9 hypertrophic hypertrophic NN cord-347246-0vofftmj 105 10 , , , cord-347246-0vofftmj 105 11 or or CC cord-347246-0vofftmj 105 12 revealed reveal VBD cord-347246-0vofftmj 105 13 squamous squamous JJ cord-347246-0vofftmj 105 14 metaplasia metaplasia NN cord-347246-0vofftmj 105 15 . . . cord-347246-0vofftmj 106 1 Subepithelial subepithelial JJ cord-347246-0vofftmj 106 2 connective connective JJ cord-347246-0vofftmj 106 3 tissue tissue NN cord-347246-0vofftmj 106 4 and and CC cord-347246-0vofftmj 106 5 submucosal submucosal NN cord-347246-0vofftmj 106 6 glands gland NNS cord-347246-0vofftmj 106 7 were be VBD cord-347246-0vofftmj 106 8 often often RB cord-347246-0vofftmj 106 9 infiltrated infiltrate VBN cord-347246-0vofftmj 106 10 by by IN cord-347246-0vofftmj 106 11 aggregates aggregate NNS cord-347246-0vofftmj 106 12 of of IN cord-347246-0vofftmj 106 13 lymphocytes lymphocyte NNS cord-347246-0vofftmj 106 14 , , , cord-347246-0vofftmj 106 15 plasma plasma NN cord-347246-0vofftmj 106 16 cells cell NNS cord-347246-0vofftmj 106 17 , , , cord-347246-0vofftmj 106 18 and and CC cord-347246-0vofftmj 106 19 neutrophils neutrophil NNS cord-347246-0vofftmj 106 20 . . . cord-347246-0vofftmj 107 1 A a DT cord-347246-0vofftmj 107 2 relatively relatively RB cord-347246-0vofftmj 107 3 small small JJ cord-347246-0vofftmj 107 4 number number NN cord-347246-0vofftmj 107 5 of of IN cord-347246-0vofftmj 107 6 cases case NNS cord-347246-0vofftmj 107 7 had have VBD cord-347246-0vofftmj 107 8 epithelial epithelial JJ cord-347246-0vofftmj 107 9 necrosis necrosis NN cord-347246-0vofftmj 107 10 associated associate VBN cord-347246-0vofftmj 107 11 with with IN cord-347246-0vofftmj 107 12 fungal fungal JJ cord-347246-0vofftmj 107 13 invasion invasion NN cord-347246-0vofftmj 107 14 . . . cord-347246-0vofftmj 108 1 A a DT cord-347246-0vofftmj 108 2 review review NN cord-347246-0vofftmj 108 3 of of IN cord-347246-0vofftmj 108 4 cases case NNS cord-347246-0vofftmj 108 5 of of IN cord-347246-0vofftmj 108 6 fungal fungal JJ cord-347246-0vofftmj 108 7 rhinitis rhinitis NN cord-347246-0vofftmj 108 8 in in IN cord-347246-0vofftmj 108 9 the the DT cord-347246-0vofftmj 108 10 National National NNP cord-347246-0vofftmj 108 11 Tbxicology Tbxicology NNP cord-347246-0vofftmj 108 12 Program Program NNP cord-347246-0vofftmj 108 13 ( ( -LRB- cord-347246-0vofftmj 108 14 NTP NTP NNP cord-347246-0vofftmj 108 15 ) ) -RRB- cord-347246-0vofftmj 108 16 archives archive NNS cord-347246-0vofftmj 108 17 revealed reveal VBD cord-347246-0vofftmj 108 18 the the DT cord-347246-0vofftmj 108 19 occurrence occurrence NN cord-347246-0vofftmj 108 20 of of IN cord-347246-0vofftmj 108 21 fungal fungal JJ cord-347246-0vofftmj 108 22 rhinitis rhinitis NN cord-347246-0vofftmj 108 23 in in IN cord-347246-0vofftmj 108 24 eight eight CD cord-347246-0vofftmj 108 25 bioassays bioassay NNS cord-347246-0vofftmj 108 26 . . . cord-347246-0vofftmj 109 1 In in IN cord-347246-0vofftmj 109 2 the the DT cord-347246-0vofftmj 109 3 affected affected JJ cord-347246-0vofftmj 109 4 studies study NNS cord-347246-0vofftmj 109 5 that that WDT cord-347246-0vofftmj 109 6 encompassed encompass VBD cord-347246-0vofftmj 109 7 animals animal NNS cord-347246-0vofftmj 109 8 that that WDT cord-347246-0vofftmj 109 9 were be VBD cord-347246-0vofftmj 109 10 both both DT cord-347246-0vofftmj 109 11 serologically serologically RB cord-347246-0vofftmj 109 12 negative negative JJ cord-347246-0vofftmj 109 13 as as RB cord-347246-0vofftmj 109 14 well well RB cord-347246-0vofftmj 109 15 as as IN cord-347246-0vofftmj 109 16 some some DT cord-347246-0vofftmj 109 17 bearing bear VBG cord-347246-0vofftmj 109 18 viral viral JJ cord-347246-0vofftmj 109 19 titers titer NNS cord-347246-0vofftmj 109 20 , , , cord-347246-0vofftmj 109 21 cases case NNS cord-347246-0vofftmj 109 22 occurred occur VBD cord-347246-0vofftmj 109 23 in in IN cord-347246-0vofftmj 109 24 both both DT cord-347246-0vofftmj 109 25 sexes sex NNS cord-347246-0vofftmj 109 26 of of IN cord-347246-0vofftmj 109 27 Fischer Fischer NNP cord-347246-0vofftmj 109 28 344 344 CD cord-347246-0vofftmj 109 29 rats rat NNS cord-347246-0vofftmj 109 30 in in IN cord-347246-0vofftmj 109 31 relatively relatively RB cord-347246-0vofftmj 109 32 low low JJ cord-347246-0vofftmj 109 33 incidence incidence NN cord-347246-0vofftmj 109 34 ( ( -LRB- cord-347246-0vofftmj 109 35 up up IN cord-347246-0vofftmj 109 36 to to TO cord-347246-0vofftmj 109 37 10 10 CD cord-347246-0vofftmj 109 38 % % NN cord-347246-0vofftmj 109 39 of of IN cord-347246-0vofftmj 109 40 a a DT cord-347246-0vofftmj 109 41 dose dose JJ cord-347246-0vofftmj 109 42 group group NN cord-347246-0vofftmj 109 43 ) ) -RRB- cord-347246-0vofftmj 109 44 . . . cord-347246-0vofftmj 110 1 A a DT cord-347246-0vofftmj 110 2 few few JJ cord-347246-0vofftmj 110 3 scattered scatter VBN cord-347246-0vofftmj 110 4 cases case NNS cord-347246-0vofftmj 110 5 were be VBD cord-347246-0vofftmj 110 6 noted note VBN cord-347246-0vofftmj 110 7 in in IN cord-347246-0vofftmj 110 8 B6C3F1 b6c3f1 JJ cord-347246-0vofftmj 110 9 mice mouse NNS cord-347246-0vofftmj 110 10 . . . cord-347246-0vofftmj 111 1 The the DT cord-347246-0vofftmj 111 2 histologic histologic JJ cord-347246-0vofftmj 111 3 appearance appearance NN cord-347246-0vofftmj 111 4 ( ( -LRB- cord-347246-0vofftmj 111 5 Plates plate NNS cord-347246-0vofftmj 111 6 5 5 CD cord-347246-0vofftmj 111 7 and and CC cord-347246-0vofftmj 111 8 6 6 CD cord-347246-0vofftmj 111 9 ) ) -RRB- cord-347246-0vofftmj 111 10 was be VBD cord-347246-0vofftmj 111 11 identical identical JJ cord-347246-0vofftmj 111 12 to to IN cord-347246-0vofftmj 111 13 that that DT cord-347246-0vofftmj 111 14 described describe VBN cord-347246-0vofftmj 111 15 in in IN cord-347246-0vofftmj 111 16 the the DT cord-347246-0vofftmj 111 17 literature literature NN cord-347246-0vofftmj 111 18 in in IN cord-347246-0vofftmj 111 19 the the DT cord-347246-0vofftmj 111 20 Wistar Wistar NNP cord-347246-0vofftmj 111 21 rat rat NN cord-347246-0vofftmj 111 22 . . . cord-347246-0vofftmj 112 1 In in IN cord-347246-0vofftmj 112 2 the the DT cord-347246-0vofftmj 112 3 affected affect VBN cord-347246-0vofftmj 112 4 bioassays bioassays NNP cord-347246-0vofftmj 112 5 the the DT cord-347246-0vofftmj 112 6 chemical chemical NN cord-347246-0vofftmj 112 7 was be VBD cord-347246-0vofftmj 112 8 administered administer VBN cord-347246-0vofftmj 112 9 by by IN cord-347246-0vofftmj 112 10 inhalation inhalation NN cord-347246-0vofftmj 112 11 , , , cord-347246-0vofftmj 112 12 feed feed NN cord-347246-0vofftmj 112 13 , , , cord-347246-0vofftmj 112 14 or or CC cord-347246-0vofftmj 112 15 gavage gavage NN cord-347246-0vofftmj 112 16 in in IN cord-347246-0vofftmj 112 17 several several JJ cord-347246-0vofftmj 112 18 different different JJ cord-347246-0vofftmj 112 19 laboratories laboratory NNS cord-347246-0vofftmj 112 20 . . . cord-347246-0vofftmj 113 1 Foreign foreign JJ cord-347246-0vofftmj 113 2 material material NN cord-347246-0vofftmj 113 3 was be VBD cord-347246-0vofftmj 113 4 noted note VBN cord-347246-0vofftmj 113 5 in in IN cord-347246-0vofftmj 113 6 most most JJS cord-347246-0vofftmj 113 7 of of IN cord-347246-0vofftmj 113 8 the the DT cord-347246-0vofftmj 113 9 cases case NNS cord-347246-0vofftmj 113 10 suggesting suggest VBG cord-347246-0vofftmj 113 11 that that IN cord-347246-0vofftmj 113 12 particles particle NNS cord-347246-0vofftmj 113 13 from from IN cord-347246-0vofftmj 113 14 food food NN cord-347246-0vofftmj 113 15 or or CC cord-347246-0vofftmj 113 16 elsewhere elsewhere RB cord-347246-0vofftmj 113 17 may may MD cord-347246-0vofftmj 113 18 serve serve VB cord-347246-0vofftmj 113 19 as as IN cord-347246-0vofftmj 113 20 local local JJ cord-347246-0vofftmj 113 21 irritants irritant NNS cord-347246-0vofftmj 113 22 and and CC cord-347246-0vofftmj 113 23 carriers carrier NNS cord-347246-0vofftmj 113 24 for for IN cord-347246-0vofftmj 113 25 the the DT cord-347246-0vofftmj 113 26 fungus fungus NN cord-347246-0vofftmj 113 27 . . . cord-347246-0vofftmj 114 1 One one CD cord-347246-0vofftmj 114 2 of of IN cord-347246-0vofftmj 114 3 the the DT cord-347246-0vofftmj 114 4 principal principal JJ cord-347246-0vofftmj 114 5 ways way NNS cord-347246-0vofftmj 114 6 in in IN cord-347246-0vofftmj 114 7 which which WDT cord-347246-0vofftmj 114 8 infectious infectious JJ cord-347246-0vofftmj 114 9 diseases disease NNS cord-347246-0vofftmj 114 10 complicate complicate VBP cord-347246-0vofftmj 114 11 toxicologic toxicologic NN cord-347246-0vofftmj 114 12 studies study NNS cord-347246-0vofftmj 114 13 is be VBZ cord-347246-0vofftmj 114 14 by by IN cord-347246-0vofftmj 114 15 interference interference NN cord-347246-0vofftmj 114 16 with with IN cord-347246-0vofftmj 114 17 the the DT cord-347246-0vofftmj 114 18 interpretation interpretation NN cord-347246-0vofftmj 114 19 of of IN cord-347246-0vofftmj 114 20 the the DT cord-347246-0vofftmj 114 21 pathology pathology NN cord-347246-0vofftmj 114 22 data datum NNS cord-347246-0vofftmj 114 23 . . . cord-347246-0vofftmj 115 1 In in IN cord-347246-0vofftmj 115 2 addition addition NN cord-347246-0vofftmj 115 3 to to IN cord-347246-0vofftmj 115 4 alterations alteration NNS cord-347246-0vofftmj 115 5 in in IN cord-347246-0vofftmj 115 6 the the DT cord-347246-0vofftmj 115 7 morphologic morphologic JJ cord-347246-0vofftmj 115 8 appearance appearance NN cord-347246-0vofftmj 115 9 of of IN cord-347246-0vofftmj 115 10 target target NN cord-347246-0vofftmj 115 11 organs organ NNS cord-347246-0vofftmj 115 12 , , , cord-347246-0vofftmj 115 13 there there EX cord-347246-0vofftmj 115 14 can can MD cord-347246-0vofftmj 115 15 be be VB cord-347246-0vofftmj 115 16 changes change NNS cord-347246-0vofftmj 115 17 in in IN cord-347246-0vofftmj 115 18 clinical clinical JJ cord-347246-0vofftmj 115 19 signs sign NNS cord-347246-0vofftmj 115 20 of of IN cord-347246-0vofftmj 115 21 toxicity toxicity NN cord-347246-0vofftmj 115 22 , , , cord-347246-0vofftmj 115 23 food food NN cord-347246-0vofftmj 115 24 consumption consumption NN cord-347246-0vofftmj 115 25 , , , cord-347246-0vofftmj 115 26 body body NN cord-347246-0vofftmj 115 27 weight weight NN cord-347246-0vofftmj 115 28 gain gain NN cord-347246-0vofftmj 115 29 , , , cord-347246-0vofftmj 115 30 hematology hematology NN cord-347246-0vofftmj 115 31 , , , cord-347246-0vofftmj 115 32 urinalysis urinalysis NN cord-347246-0vofftmj 115 33 , , , cord-347246-0vofftmj 115 34 and and CC cord-347246-0vofftmj 115 35 serum serum NN cord-347246-0vofftmj 115 36 chemistry chemistry NN cord-347246-0vofftmj 115 37 parameters parameter NNS cord-347246-0vofftmj 115 38 ( ( -LRB- cord-347246-0vofftmj 115 39 27 27 CD cord-347246-0vofftmj 115 40 ) ) -RRB- cord-347246-0vofftmj 115 41 . . . cord-347246-0vofftmj 116 1 Body body NN cord-347246-0vofftmj 116 2 weight weight NN cord-347246-0vofftmj 116 3 gain gain VBP cord-347246-0vofftmj 116 4 depression depression NN cord-347246-0vofftmj 116 5 of of IN cord-347246-0vofftmj 116 6 greater great JJR cord-347246-0vofftmj 116 7 than than IN cord-347246-0vofftmj 116 8 10 10 CD cord-347246-0vofftmj 116 9 % % NN cord-347246-0vofftmj 116 10 is be VBZ cord-347246-0vofftmj 116 11 often often RB cord-347246-0vofftmj 116 12 considered consider VBN cord-347246-0vofftmj 116 13 to to TO cord-347246-0vofftmj 116 14 be be VB cord-347246-0vofftmj 116 15 a a DT cord-347246-0vofftmj 116 16 sign sign NN cord-347246-0vofftmj 116 17 of of IN cord-347246-0vofftmj 116 18 toxicity toxicity NN cord-347246-0vofftmj 116 19 in in IN cord-347246-0vofftmj 116 20 treated treat VBN cord-347246-0vofftmj 116 21 groups group NNS cord-347246-0vofftmj 116 22 of of IN cord-347246-0vofftmj 116 23 animals animal NNS cord-347246-0vofftmj 116 24 . . . cord-347246-0vofftmj 117 1 The the DT cord-347246-0vofftmj 117 2 combined combined JJ cord-347246-0vofftmj 117 3 effects effect NNS cord-347246-0vofftmj 117 4 of of IN cord-347246-0vofftmj 117 5 infection infection NN cord-347246-0vofftmj 117 6 and and CC cord-347246-0vofftmj 117 7 treatment treatment NN cord-347246-0vofftmj 117 8 influence influence NN cord-347246-0vofftmj 117 9 food food NN cord-347246-0vofftmj 117 10 consumption consumption NN cord-347246-0vofftmj 117 11 and and CC cord-347246-0vofftmj 117 12 body body NN cord-347246-0vofftmj 117 13 weight weight NN cord-347246-0vofftmj 117 14 gain gain NN cord-347246-0vofftmj 117 15 to to IN cord-347246-0vofftmj 117 16 a a DT cord-347246-0vofftmj 117 17 greater great JJR cord-347246-0vofftmj 117 18 extent extent NN cord-347246-0vofftmj 117 19 than than IN cord-347246-0vofftmj 117 20 infection infection NN cord-347246-0vofftmj 117 21 or or CC cord-347246-0vofftmj 117 22 chemical chemical NN cord-347246-0vofftmj 117 23 treatment treatment NN cord-347246-0vofftmj 117 24 alone alone RB cord-347246-0vofftmj 117 25 . . . cord-347246-0vofftmj 118 1 This this DT cord-347246-0vofftmj 118 2 synergism synergism NN cord-347246-0vofftmj 118 3 can can MD cord-347246-0vofftmj 118 4 confound confound VB cord-347246-0vofftmj 118 5 data datum NNS cord-347246-0vofftmj 118 6 interpretation interpretation NN cord-347246-0vofftmj 118 7 ( ( -LRB- cord-347246-0vofftmj 118 8 27 27 CD cord-347246-0vofftmj 118 9 ) ) -RRB- cord-347246-0vofftmj 118 10 . . . cord-347246-0vofftmj 119 1 It -PRON- PRP cord-347246-0vofftmj 119 2 has have VBZ cord-347246-0vofftmj 119 3 recently recently RB cord-347246-0vofftmj 119 4 become become VBN cord-347246-0vofftmj 119 5 apparent apparent JJ cord-347246-0vofftmj 119 6 that that IN cord-347246-0vofftmj 119 7 infectious infectious JJ cord-347246-0vofftmj 119 8 agents agent NNS cord-347246-0vofftmj 119 9 can can MD cord-347246-0vofftmj 119 10 markedly markedly RB cord-347246-0vofftmj 119 11 affect affect VB cord-347246-0vofftmj 119 12 the the DT cord-347246-0vofftmj 119 13 metabolism metabolism NN cord-347246-0vofftmj 119 14 of of IN cord-347246-0vofftmj 119 15 foreign foreign JJ cord-347246-0vofftmj 119 16 compounds compound NNS cord-347246-0vofftmj 119 17 by by IN cord-347246-0vofftmj 119 18 impairing impair VBG cord-347246-0vofftmj 119 19 hepatic hepatic JJ cord-347246-0vofftmj 119 20 mixed mixed JJ cord-347246-0vofftmj 119 21 - - HYPH cord-347246-0vofftmj 119 22 function function NN cord-347246-0vofftmj 119 23 monoxygenases monoxygenase NNS cord-347246-0vofftmj 119 24 ( ( -LRB- cord-347246-0vofftmj 119 25 cytochrome cytochrome NN cord-347246-0vofftmj 119 26 P-450-dependent p-450-dependent NN cord-347246-0vofftmj 119 27 monoxygenase monoxygenase NN cord-347246-0vofftmj 119 28 system system NN cord-347246-0vofftmj 119 29 ) ) -RRB- cord-347246-0vofftmj 119 30 ( ( -LRB- cord-347246-0vofftmj 119 31 28 28 CD cord-347246-0vofftmj 119 32 ) ) -RRB- cord-347246-0vofftmj 119 33 . . . cord-347246-0vofftmj 120 1 Alteration alteration NN cord-347246-0vofftmj 120 2 of of IN cord-347246-0vofftmj 120 3 xenobiotic xenobiotic JJ cord-347246-0vofftmj 120 4 metabolism metabolism NN cord-347246-0vofftmj 120 5 has have VBZ cord-347246-0vofftmj 120 6 important important JJ cord-347246-0vofftmj 120 7 ramifications ramification NNS cord-347246-0vofftmj 120 8 for for IN cord-347246-0vofftmj 120 9 toxicologists toxicologist NNS cord-347246-0vofftmj 120 10 who who WP cord-347246-0vofftmj 120 11 administer administer VBP cord-347246-0vofftmj 120 12 compounds compound NNS cord-347246-0vofftmj 120 13 that that WDT cord-347246-0vofftmj 120 14 are be VBP cord-347246-0vofftmj 120 15 subject subject JJ cord-347246-0vofftmj 120 16 to to IN cord-347246-0vofftmj 120 17 bioactivation bioactivation NN cord-347246-0vofftmj 120 18 and and CC cord-347246-0vofftmj 120 19 biotransformation biotransformation NN cord-347246-0vofftmj 120 20 . . . cord-347246-0vofftmj 121 1 The the DT cord-347246-0vofftmj 121 2 mechanistic mechanistic JJ cord-347246-0vofftmj 121 3 basis basis NN cord-347246-0vofftmj 121 4 for for IN cord-347246-0vofftmj 121 5 the the DT cord-347246-0vofftmj 121 6 microbialinduced microbialinduce VBN cord-347246-0vofftmj 121 7 inhibition inhibition NN cord-347246-0vofftmj 121 8 of of IN cord-347246-0vofftmj 121 9 biotransformation biotransformation NN cord-347246-0vofftmj 121 10 has have VBZ cord-347246-0vofftmj 121 11 not not RB cord-347246-0vofftmj 121 12 yet yet RB cord-347246-0vofftmj 121 13 been be VBN cord-347246-0vofftmj 121 14 completely completely RB cord-347246-0vofftmj 121 15 elucidated elucidate VBN cord-347246-0vofftmj 121 16 . . . cord-347246-0vofftmj 122 1 It -PRON- PRP cord-347246-0vofftmj 122 2 appears appear VBZ cord-347246-0vofftmj 122 3 that that IN cord-347246-0vofftmj 122 4 interferon interferon NN cord-347246-0vofftmj 122 5 induction induction NN cord-347246-0vofftmj 122 6 as as IN cord-347246-0vofftmj 122 7 a a DT cord-347246-0vofftmj 122 8 result result NN cord-347246-0vofftmj 122 9 of of IN cord-347246-0vofftmj 122 10 infection infection NN cord-347246-0vofftmj 122 11 can can MD cord-347246-0vofftmj 122 12 act act VB cord-347246-0vofftmj 122 13 as as IN cord-347246-0vofftmj 122 14 a a DT cord-347246-0vofftmj 122 15 mediator mediator NN cord-347246-0vofftmj 122 16 in in IN cord-347246-0vofftmj 122 17 depressing depress VBG cord-347246-0vofftmj 122 18 P-450 p-450 NN cord-347246-0vofftmj 122 19 , , , cord-347246-0vofftmj 122 20 and and CC cord-347246-0vofftmj 122 21 it -PRON- PRP cord-347246-0vofftmj 122 22 may may MD cord-347246-0vofftmj 122 23 have have VB cord-347246-0vofftmj 122 24 a a DT cord-347246-0vofftmj 122 25 direct direct JJ cord-347246-0vofftmj 122 26 action action NN cord-347246-0vofftmj 122 27 on on IN cord-347246-0vofftmj 122 28 the the DT cord-347246-0vofftmj 122 29 hemoprotein hemoprotein NN cord-347246-0vofftmj 122 30 itself -PRON- PRP cord-347246-0vofftmj 122 31 ( ( -LRB- cord-347246-0vofftmj 122 32 28 28 CD cord-347246-0vofftmj 122 33 ) ) -RRB- cord-347246-0vofftmj 122 34 . . . cord-347246-0vofftmj 123 1 Many many JJ cord-347246-0vofftmj 123 2 of of IN cord-347246-0vofftmj 123 3 the the DT cord-347246-0vofftmj 123 4 important important JJ cord-347246-0vofftmj 123 5 murine murine JJ cord-347246-0vofftmj 123 6 viral viral JJ cord-347246-0vofftmj 123 7 agents agent NNS cord-347246-0vofftmj 123 8 including include VBG cord-347246-0vofftmj 123 9 Sendai Sendai NNP cord-347246-0vofftmj 123 10 virus virus NN cord-347246-0vofftmj 123 11 are be VBP cord-347246-0vofftmj 123 12 potent potent JJ cord-347246-0vofftmj 123 13 inducers inducer NNS cord-347246-0vofftmj 123 14 of of IN cord-347246-0vofftmj 123 15 interferon interferon NN cord-347246-0vofftmj 123 16 ( ( -LRB- cord-347246-0vofftmj 123 17 29 29 CD cord-347246-0vofftmj 123 18 ) ) -RRB- cord-347246-0vofftmj 123 19 . . . cord-347246-0vofftmj 124 1 Infectious infectious JJ cord-347246-0vofftmj 124 2 diseases disease NNS cord-347246-0vofftmj 124 3 can can MD cord-347246-0vofftmj 124 4 also also RB cord-347246-0vofftmj 124 5 modulate modulate VB cord-347246-0vofftmj 124 6 hepatic hepatic JJ cord-347246-0vofftmj 124 7 cytochrome cytochrome NN cord-347246-0vofftmj 124 8 P-450 p-450 XX cord-347246-0vofftmj 124 9 by by IN cord-347246-0vofftmj 124 10 effects effect NNS cord-347246-0vofftmj 124 11 on on IN cord-347246-0vofftmj 124 12 the the DT cord-347246-0vofftmj 124 13 reticuloendothelial reticuloendothelial JJ cord-347246-0vofftmj 124 14 system system NN cord-347246-0vofftmj 124 15 . . . cord-347246-0vofftmj 125 1 Furthermore furthermore RB cord-347246-0vofftmj 125 2 , , , cord-347246-0vofftmj 125 3 microbial microbial JJ cord-347246-0vofftmj 125 4 agents agent NNS cord-347246-0vofftmj 125 5 that that WDT cord-347246-0vofftmj 125 6 perturb perturb VBP cord-347246-0vofftmj 125 7 Kupffer Kupffer NNP cord-347246-0vofftmj 125 8 cells cell NNS cord-347246-0vofftmj 125 9 decrease decrease VBP cord-347246-0vofftmj 125 10 drug drug NN cord-347246-0vofftmj 125 11 biotransformation biotransformation NN cord-347246-0vofftmj 125 12 activity activity NN cord-347246-0vofftmj 125 13 ( ( -LRB- cord-347246-0vofftmj 125 14 28 28 CD cord-347246-0vofftmj 125 15 ) ) -RRB- cord-347246-0vofftmj 125 16 . . . cord-347246-0vofftmj 126 1 Effects effect NNS cord-347246-0vofftmj 126 2 on on IN cord-347246-0vofftmj 126 3 nonhepatic nonhepatic NNP cord-347246-0vofftmj 126 4 xenobiotic xenobiotic JJ cord-347246-0vofftmj 126 5 metabolism metabolism NN cord-347246-0vofftmj 126 6 by by IN cord-347246-0vofftmj 126 7 infectious infectious JJ cord-347246-0vofftmj 126 8 agents agent NNS cord-347246-0vofftmj 126 9 have have VBP cord-347246-0vofftmj 126 10 received receive VBN cord-347246-0vofftmj 126 11 little little JJ cord-347246-0vofftmj 126 12 attention attention NN cord-347246-0vofftmj 126 13 . . . cord-347246-0vofftmj 127 1 Several several JJ cord-347246-0vofftmj 127 2 upper upper JJ cord-347246-0vofftmj 127 3 respiratory respiratory JJ cord-347246-0vofftmj 127 4 viral viral JJ cord-347246-0vofftmj 127 5 infections infection NNS cord-347246-0vofftmj 127 6 in in IN cord-347246-0vofftmj 127 7 man man NN cord-347246-0vofftmj 127 8 , , , cord-347246-0vofftmj 127 9 including include VBG cord-347246-0vofftmj 127 10 rhinoviruses rhinovirus NNS cord-347246-0vofftmj 127 11 and and CC cord-347246-0vofftmj 127 12 influenza influenza NN cord-347246-0vofftmj 127 13 viruses virus NNS cord-347246-0vofftmj 127 14 , , , cord-347246-0vofftmj 127 15 are be VBP cord-347246-0vofftmj 127 16 known know VBN cord-347246-0vofftmj 127 17 to to TO cord-347246-0vofftmj 127 18 impair impair VB cord-347246-0vofftmj 127 19 drug drug NN cord-347246-0vofftmj 127 20 biotransformations biotransformation NNS cord-347246-0vofftmj 127 21 by by IN cord-347246-0vofftmj 127 22 affecting affect VBG cord-347246-0vofftmj 127 23 the the DT cord-347246-0vofftmj 127 24 cytochrome cytochrome NN cord-347246-0vofftmj 127 25 P-450 p-450 NN cord-347246-0vofftmj 127 26 system system NN cord-347246-0vofftmj 127 27 ( ( -LRB- cord-347246-0vofftmj 127 28 28 28 CD cord-347246-0vofftmj 127 29 ) ) -RRB- cord-347246-0vofftmj 127 30 . . . cord-347246-0vofftmj 128 1 Similar similar JJ cord-347246-0vofftmj 128 2 viral viral JJ cord-347246-0vofftmj 128 3 effects effect NNS cord-347246-0vofftmj 128 4 have have VBP cord-347246-0vofftmj 128 5 been be VBN cord-347246-0vofftmj 128 6 demonstrated demonstrate VBN cord-347246-0vofftmj 128 7 in in IN cord-347246-0vofftmj 128 8 PR8 PR8 NNP cord-347246-0vofftmj 128 9 influenza influenza NN cord-347246-0vofftmj 128 10 - - HYPH cord-347246-0vofftmj 128 11 infected infect VBN cord-347246-0vofftmj 128 12 mice mouse NNS cord-347246-0vofftmj 128 13 ( ( -LRB- cord-347246-0vofftmj 128 14 30 30 CD cord-347246-0vofftmj 128 15 ) ) -RRB- cord-347246-0vofftmj 128 16 . . . cord-347246-0vofftmj 129 1 Mice mouse NNS cord-347246-0vofftmj 129 2 infected infect VBN cord-347246-0vofftmj 129 3 with with IN cord-347246-0vofftmj 129 4 this this DT cord-347246-0vofftmj 129 5 virus virus NN cord-347246-0vofftmj 129 6 have have VBP cord-347246-0vofftmj 129 7 significantly significantly RB cord-347246-0vofftmj 129 8 decreased decrease VBN cord-347246-0vofftmj 129 9 pulmonary pulmonary JJ cord-347246-0vofftmj 129 10 benzo[a]pyrene benzo[a]pyrene JJ cord-347246-0vofftmj 129 11 hydroxylase hydroxylase NN cord-347246-0vofftmj 129 12 activity activity NN cord-347246-0vofftmj 129 13 . . . cord-347246-0vofftmj 130 1 Nasal nasal NN cord-347246-0vofftmj 130 2 cytochrome cytochrome NN cord-347246-0vofftmj 130 3 P-450-dependent p-450-dependent NN cord-347246-0vofftmj 130 4 monooxygenases monooxygenase NNS cord-347246-0vofftmj 130 5 may may MD cord-347246-0vofftmj 130 6 be be VB cord-347246-0vofftmj 130 7 extremely extremely RB cord-347246-0vofftmj 130 8 important important JJ cord-347246-0vofftmj 130 9 in in IN cord-347246-0vofftmj 130 10 the the DT cord-347246-0vofftmj 130 11 bioactivation bioactivation NN cord-347246-0vofftmj 130 12 and and CC cord-347246-0vofftmj 130 13 biotransformation biotransformation NN cord-347246-0vofftmj 130 14 of of IN cord-347246-0vofftmj 130 15 inhaled inhale VBN cord-347246-0vofftmj 130 16 xenobiotics xenobiotic NNS cord-347246-0vofftmj 130 17 . . . cord-347246-0vofftmj 131 1 In in IN cord-347246-0vofftmj 131 2 most most JJS cord-347246-0vofftmj 131 3 species specie NNS cord-347246-0vofftmj 131 4 , , , cord-347246-0vofftmj 131 5 the the DT cord-347246-0vofftmj 131 6 nasal nasal NN cord-347246-0vofftmj 131 7 olfactory olfactory JJ cord-347246-0vofftmj 131 8 concentration concentration NN cord-347246-0vofftmj 131 9 of of IN cord-347246-0vofftmj 131 10 these these DT cord-347246-0vofftmj 131 11 enzymes enzyme NNS cord-347246-0vofftmj 131 12 is be VBZ cord-347246-0vofftmj 131 13 second second JJ cord-347246-0vofftmj 131 14 only only RB cord-347246-0vofftmj 131 15 to to IN cord-347246-0vofftmj 131 16 that that DT cord-347246-0vofftmj 131 17 found find VBN cord-347246-0vofftmj 131 18 in in IN cord-347246-0vofftmj 131 19 the the DT cord-347246-0vofftmj 131 20 liver liver NN cord-347246-0vofftmj 131 21 ( ( -LRB- cord-347246-0vofftmj 131 22 31 31 CD cord-347246-0vofftmj 131 23 ) ) -RRB- cord-347246-0vofftmj 131 24 . . . cord-347246-0vofftmj 132 1 Mouse Mouse NNP cord-347246-0vofftmj 132 2 hepatitis hepatitis NN cord-347246-0vofftmj 132 3 virus virus NN cord-347246-0vofftmj 132 4 , , , cord-347246-0vofftmj 132 5 a a DT cord-347246-0vofftmj 132 6 common common JJ cord-347246-0vofftmj 132 7 mouse mouse NN cord-347246-0vofftmj 132 8 coronavirus coronavirus NN cord-347246-0vofftmj 132 9 infection infection NN cord-347246-0vofftmj 132 10 , , , cord-347246-0vofftmj 132 11 is be VBZ cord-347246-0vofftmj 132 12 reported report VBN cord-347246-0vofftmj 132 13 to to TO cord-347246-0vofftmj 132 14 depress depress VB cord-347246-0vofftmj 132 15 hepatic hepatic JJ cord-347246-0vofftmj 132 16 P-450 p-450 NN cord-347246-0vofftmj 132 17 levels level NNS cord-347246-0vofftmj 132 18 ( ( -LRB- cord-347246-0vofftmj 132 19 32 32 CD cord-347246-0vofftmj 132 20 ) ) -RRB- cord-347246-0vofftmj 132 21 . . . cord-347246-0vofftmj 133 1 Strains strain NNS cord-347246-0vofftmj 133 2 of of IN cord-347246-0vofftmj 133 3 this this DT cord-347246-0vofftmj 133 4 pathogen pathogen NN cord-347246-0vofftmj 133 5 cause cause VB cord-347246-0vofftmj 133 6 nasal nasal NN cord-347246-0vofftmj 133 7 cavity cavity NN cord-347246-0vofftmj 133 8 infections infection NNS cord-347246-0vofftmj 133 9 with with IN cord-347246-0vofftmj 133 10 necrotizing necrotize VBG cord-347246-0vofftmj 133 11 lesions lesion NNS cord-347246-0vofftmj 133 12 in in IN cord-347246-0vofftmj 133 13 the the DT cord-347246-0vofftmj 133 14 olfactory olfactory JJ cord-347246-0vofftmj 133 15 mucosa mucosa NN cord-347246-0vofftmj 133 16 ( ( -LRB- cord-347246-0vofftmj 133 17 33 33 CD cord-347246-0vofftmj 133 18 ) ) -RRB- cord-347246-0vofftmj 133 19 . . . cord-347246-0vofftmj 134 1 It -PRON- PRP cord-347246-0vofftmj 134 2 is be VBZ cord-347246-0vofftmj 134 3 therefore therefore RB cord-347246-0vofftmj 134 4 possible possible JJ cord-347246-0vofftmj 134 5 that that IN cord-347246-0vofftmj 134 6 extrahepatic extrahepatic JJ cord-347246-0vofftmj 134 7 alterations alteration NNS cord-347246-0vofftmj 134 8 of of IN cord-347246-0vofftmj 134 9 P-450 p-450 NN cord-347246-0vofftmj 134 10 may may MD cord-347246-0vofftmj 134 11 result result VB cord-347246-0vofftmj 134 12 and and CC cord-347246-0vofftmj 134 13 be be VB cord-347246-0vofftmj 134 14 of of IN cord-347246-0vofftmj 134 15 importance importance NN cord-347246-0vofftmj 134 16 to to IN cord-347246-0vofftmj 134 17 toxicology toxicology NN cord-347246-0vofftmj 134 18 studies study NNS cord-347246-0vofftmj 134 19 . . . cord-347246-0vofftmj 135 1 In in IN cord-347246-0vofftmj 135 2 addition addition NN cord-347246-0vofftmj 135 3 to to IN cord-347246-0vofftmj 135 4 alterations alteration NNS cord-347246-0vofftmj 135 5 of of IN cord-347246-0vofftmj 135 6 xenobiotic xenobiotic JJ cord-347246-0vofftmj 135 7 metabolism metabolism NN cord-347246-0vofftmj 135 8 , , , cord-347246-0vofftmj 135 9 infectious infectious JJ cord-347246-0vofftmj 135 10 diseases disease NNS cord-347246-0vofftmj 135 11 cause cause VBP cord-347246-0vofftmj 135 12 other other JJ cord-347246-0vofftmj 135 13 cellular cellular JJ cord-347246-0vofftmj 135 14 effects effect NNS cord-347246-0vofftmj 135 15 that that WDT cord-347246-0vofftmj 135 16 can can MD cord-347246-0vofftmj 135 17 modulate modulate VB cord-347246-0vofftmj 135 18 toxic toxic JJ cord-347246-0vofftmj 135 19 and and CC cord-347246-0vofftmj 135 20 carcinogenic carcinogenic JJ cord-347246-0vofftmj 135 21 responses response NNS cord-347246-0vofftmj 135 22 . . . cord-347246-0vofftmj 136 1 The the DT cord-347246-0vofftmj 136 2 association association NN cord-347246-0vofftmj 136 3 between between IN cord-347246-0vofftmj 136 4 enhanced enhanced JJ cord-347246-0vofftmj 136 5 cell cell NN cord-347246-0vofftmj 136 6 replication replication NN cord-347246-0vofftmj 136 7 and and CC cord-347246-0vofftmj 136 8 cancer cancer NN cord-347246-0vofftmj 136 9 induction induction NN cord-347246-0vofftmj 136 10 has have VBZ cord-347246-0vofftmj 136 11 gained gain VBN cord-347246-0vofftmj 136 12 the the DT cord-347246-0vofftmj 136 13 interests interest NNS cord-347246-0vofftmj 136 14 of of IN cord-347246-0vofftmj 136 15 many many JJ cord-347246-0vofftmj 136 16 toxicologists toxicologist NNS cord-347246-0vofftmj 136 17 ( ( -LRB- cord-347246-0vofftmj 136 18 34 34 CD cord-347246-0vofftmj 136 19 ) ) -RRB- cord-347246-0vofftmj 136 20 . . . cord-347246-0vofftmj 137 1 Gross gross JJ cord-347246-0vofftmj 137 2 and and CC cord-347246-0vofftmj 137 3 co co NNS cord-347246-0vofftmj 137 4 - - NNS cord-347246-0vofftmj 137 5 workers worker NNS cord-347246-0vofftmj 137 6 found find VBN cord-347246-0vofftmj 137 7 that that IN cord-347246-0vofftmj 137 8 sites site NNS cord-347246-0vofftmj 137 9 of of IN cord-347246-0vofftmj 137 10 cell cell NN cord-347246-0vofftmj 137 11 replication replication NN cord-347246-0vofftmj 137 12 correlated correlate VBN cord-347246-0vofftmj 137 13 well well RB cord-347246-0vofftmj 137 14 with with IN cord-347246-0vofftmj 137 15 sites site NNS cord-347246-0vofftmj 137 16 of of IN cord-347246-0vofftmj 137 17 tumor tumor NN cord-347246-0vofftmj 137 18 induction induction NN cord-347246-0vofftmj 137 19 in in IN cord-347246-0vofftmj 137 20 the the DT cord-347246-0vofftmj 137 21 nasal nasal NN cord-347246-0vofftmj 137 22 cavities cavity NNS cord-347246-0vofftmj 137 23 from from IN cord-347246-0vofftmj 137 24 rats rat NNS cord-347246-0vofftmj 137 25 exposed expose VBN cord-347246-0vofftmj 137 26 to to IN cord-347246-0vofftmj 137 27 formaldehyde formaldehyde NN cord-347246-0vofftmj 137 28 in in IN cord-347246-0vofftmj 137 29 acute acute JJ cord-347246-0vofftmj 137 30 and and CC cord-347246-0vofftmj 137 31 chronic chronic JJ cord-347246-0vofftmj 137 32 inhalation inhalation NN cord-347246-0vofftmj 137 33 studies study NNS cord-347246-0vofftmj 137 34 ( ( -LRB- cord-347246-0vofftmj 137 35 35 35 CD cord-347246-0vofftmj 137 36 ) ) -RRB- cord-347246-0vofftmj 137 37 . . . cord-347246-0vofftmj 138 1 Although although IN cord-347246-0vofftmj 138 2 it -PRON- PRP cord-347246-0vofftmj 138 3 is be VBZ cord-347246-0vofftmj 138 4 uncertain uncertain JJ cord-347246-0vofftmj 138 5 how how WRB cord-347246-0vofftmj 138 6 enhanced enhanced JJ cord-347246-0vofftmj 138 7 cell cell NN cord-347246-0vofftmj 138 8 replication replication NN cord-347246-0vofftmj 138 9 affects affect VBZ cord-347246-0vofftmj 138 10 the the DT cord-347246-0vofftmj 138 11 carcinogenic carcinogenic JJ cord-347246-0vofftmj 138 12 process process NN cord-347246-0vofftmj 138 13 , , , cord-347246-0vofftmj 138 14 such such JJ cord-347246-0vofftmj 138 15 correlations correlation NNS cord-347246-0vofftmj 138 16 suggest suggest VBP cord-347246-0vofftmj 138 17 that that IN cord-347246-0vofftmj 138 18 a a DT cord-347246-0vofftmj 138 19 cause cause NN cord-347246-0vofftmj 138 20 and and CC cord-347246-0vofftmj 138 21 effect effect NN cord-347246-0vofftmj 138 22 relationship relationship NN cord-347246-0vofftmj 138 23 may may MD cord-347246-0vofftmj 138 24 exist exist VB cord-347246-0vofftmj 138 25 . . . cord-347246-0vofftmj 139 1 Infectious infectious JJ cord-347246-0vofftmj 139 2 diseases disease NNS cord-347246-0vofftmj 139 3 that that WDT cord-347246-0vofftmj 139 4 cause cause VBP cord-347246-0vofftmj 139 5 epithelial epithelial JJ cord-347246-0vofftmj 139 6 necrosis necrosis NN cord-347246-0vofftmj 139 7 and and CC cord-347246-0vofftmj 139 8 repair repair NN cord-347246-0vofftmj 139 9 lead lead NN cord-347246-0vofftmj 139 10 to to IN cord-347246-0vofftmj 139 11 significant significant JJ cord-347246-0vofftmj 139 12 alterations alteration NNS cord-347246-0vofftmj 139 13 in in IN cord-347246-0vofftmj 139 14 cell cell NN cord-347246-0vofftmj 139 15 turnover turnover NN cord-347246-0vofftmj 139 16 . . . cord-347246-0vofftmj 140 1 Microbial microbial JJ cord-347246-0vofftmj 140 2 agents agent NNS cord-347246-0vofftmj 140 3 such such JJ cord-347246-0vofftmj 140 4 as as IN cord-347246-0vofftmj 140 5 M. M. NNP cord-347246-0vofftmj 140 6 pulmonis pulmonis NNP cord-347246-0vofftmj 140 7 are be VBP cord-347246-0vofftmj 140 8 known know VBN cord-347246-0vofftmj 140 9 to to TO cord-347246-0vofftmj 140 10 cause cause VB cord-347246-0vofftmj 140 11 significant significant JJ cord-347246-0vofftmj 140 12 alterations alteration NNS cord-347246-0vofftmj 140 13 in in IN cord-347246-0vofftmj 140 14 cell cell NN cord-347246-0vofftmj 140 15 cycle cycle NN cord-347246-0vofftmj 140 16 kinetics kinetic NNS cord-347246-0vofftmj 140 17 in in IN cord-347246-0vofftmj 140 18 populations population NNS cord-347246-0vofftmj 140 19 of of IN cord-347246-0vofftmj 140 20 upper upper JJ cord-347246-0vofftmj 140 21 airway airway NN cord-347246-0vofftmj 140 22 epithelial epithelial JJ cord-347246-0vofftmj 140 23 cells cell NNS cord-347246-0vofftmj 140 24 ( ( -LRB- cord-347246-0vofftmj 140 25 36 36 CD cord-347246-0vofftmj 140 26 ) ) -RRB- cord-347246-0vofftmj 140 27 . . . cord-347246-0vofftmj 141 1 This this DT cord-347246-0vofftmj 141 2 clearly clearly RB cord-347246-0vofftmj 141 3 has have VBZ cord-347246-0vofftmj 141 4 profound profound JJ cord-347246-0vofftmj 141 5 implications implication NNS cord-347246-0vofftmj 141 6 for for IN cord-347246-0vofftmj 141 7 carcinogenesis carcinogenesis NN cord-347246-0vofftmj 141 8 studies study NNS cord-347246-0vofftmj 141 9 in in IN cord-347246-0vofftmj 141 10 which which WDT cord-347246-0vofftmj 141 11 cell cell NN cord-347246-0vofftmj 141 12 turnover turnover NN cord-347246-0vofftmj 141 13 may may MD cord-347246-0vofftmj 141 14 be be VB cord-347246-0vofftmj 141 15 an an DT cord-347246-0vofftmj 141 16 important important JJ cord-347246-0vofftmj 141 17 contributing contribute VBG cord-347246-0vofftmj 141 18 factor factor NN cord-347246-0vofftmj 141 19 in in IN cord-347246-0vofftmj 141 20 the the DT cord-347246-0vofftmj 141 21 multistage multistage NN cord-347246-0vofftmj 141 22 process process NN cord-347246-0vofftmj 141 23 . . . cord-347246-0vofftmj 142 1 Not not RB cord-347246-0vofftmj 142 2 only only RB cord-347246-0vofftmj 142 3 would would MD cord-347246-0vofftmj 142 4 the the DT cord-347246-0vofftmj 142 5 microbial microbial JJ cord-347246-0vofftmj 142 6 infection infection NN cord-347246-0vofftmj 142 7 and and CC cord-347246-0vofftmj 142 8 degree degree NN cord-347246-0vofftmj 142 9 of of IN cord-347246-0vofftmj 142 10 cell cell NN cord-347246-0vofftmj 142 11 turnover turnover NN cord-347246-0vofftmj 142 12 be be VB cord-347246-0vofftmj 142 13 important important JJ cord-347246-0vofftmj 142 14 , , , cord-347246-0vofftmj 142 15 but but CC cord-347246-0vofftmj 142 16 the the DT cord-347246-0vofftmj 142 17 chronology chronology NN cord-347246-0vofftmj 142 18 of of IN cord-347246-0vofftmj 142 19 the the DT cord-347246-0vofftmj 142 20 infection infection NN cord-347246-0vofftmj 142 21 with with IN cord-347246-0vofftmj 142 22 regard regard NN cord-347246-0vofftmj 142 23 to to IN cord-347246-0vofftmj 142 24 the the DT cord-347246-0vofftmj 142 25 chemical chemical JJ cord-347246-0vofftmj 142 26 administration administration NN cord-347246-0vofftmj 142 27 could could MD cord-347246-0vofftmj 142 28 prove prove VB cord-347246-0vofftmj 142 29 critical critical JJ cord-347246-0vofftmj 142 30 . . . cord-347246-0vofftmj 143 1 A a DT cord-347246-0vofftmj 143 2 variety variety NN cord-347246-0vofftmj 143 3 of of IN cord-347246-0vofftmj 143 4 important important JJ cord-347246-0vofftmj 143 5 microbial microbial JJ cord-347246-0vofftmj 143 6 pathogens pathogen NNS cord-347246-0vofftmj 143 7 including include VBG cord-347246-0vofftmj 143 8 viruses virus NNS cord-347246-0vofftmj 143 9 , , , cord-347246-0vofftmj 143 10 mycoplasmas mycoplasmas NN cord-347246-0vofftmj 143 11 , , , cord-347246-0vofftmj 143 12 bacteria bacteria NNS cord-347246-0vofftmj 143 13 , , , cord-347246-0vofftmj 143 14 and and CC cord-347246-0vofftmj 143 15 fungi fungus NNS cord-347246-0vofftmj 143 16 infect infect VBP cord-347246-0vofftmj 143 17 the the DT cord-347246-0vofftmj 143 18 upper upper JJ cord-347246-0vofftmj 143 19 respiratory respiratory JJ cord-347246-0vofftmj 143 20 tract tract NN cord-347246-0vofftmj 143 21 of of IN cord-347246-0vofftmj 143 22 the the DT cord-347246-0vofftmj 143 23 mouse mouse NN cord-347246-0vofftmj 143 24 and and CC cord-347246-0vofftmj 143 25 rat rat NN cord-347246-0vofftmj 143 26 and and CC cord-347246-0vofftmj 143 27 result result VB cord-347246-0vofftmj 143 28 in in IN cord-347246-0vofftmj 143 29 significant significant JJ cord-347246-0vofftmj 143 30 pathologic pathologic JJ cord-347246-0vofftmj 143 31 alterations alteration NNS cord-347246-0vofftmj 143 32 . . . cord-347246-0vofftmj 144 1 The the DT cord-347246-0vofftmj 144 2 rodent rodent NN cord-347246-0vofftmj 144 3 upper upper JJ cord-347246-0vofftmj 144 4 respiratory respiratory JJ cord-347246-0vofftmj 144 5 tract tract NN cord-347246-0vofftmj 144 6 may may MD cord-347246-0vofftmj 144 7 also also RB cord-347246-0vofftmj 144 8 be be VB cord-347246-0vofftmj 144 9 an an DT cord-347246-0vofftmj 144 10 important important JJ cord-347246-0vofftmj 144 11 target target NN cord-347246-0vofftmj 144 12 organ organ NN cord-347246-0vofftmj 144 13 in in IN cord-347246-0vofftmj 144 14 chronic chronic JJ cord-347246-0vofftmj 144 15 bioassays bioassay NNS cord-347246-0vofftmj 144 16 . . . cord-347246-0vofftmj 145 1 lbxicologists lbxicologists NNP cord-347246-0vofftmj 145 2 and and CC cord-347246-0vofftmj 145 3 pathologists pathologist NNS cord-347246-0vofftmj 145 4 need need VBP cord-347246-0vofftmj 145 5 to to TO cord-347246-0vofftmj 145 6 understand understand VB cord-347246-0vofftmj 145 7 the the DT cord-347246-0vofftmj 145 8 etiopathogenesis etiopathogenesis NN cord-347246-0vofftmj 145 9 of of IN cord-347246-0vofftmj 145 10 common common JJ cord-347246-0vofftmj 145 11 pathogen pathogen NN cord-347246-0vofftmj 145 12 - - HYPH cord-347246-0vofftmj 145 13 related relate VBN cord-347246-0vofftmj 145 14 diseases disease NNS cord-347246-0vofftmj 145 15 in in IN cord-347246-0vofftmj 145 16 the the DT cord-347246-0vofftmj 145 17 murine murine JJ cord-347246-0vofftmj 145 18 respiratory respiratory JJ cord-347246-0vofftmj 145 19 tract tract NN cord-347246-0vofftmj 145 20 , , , cord-347246-0vofftmj 145 21 so so IN cord-347246-0vofftmj 145 22 that that IN cord-347246-0vofftmj 145 23 the the DT cord-347246-0vofftmj 145 24 effects effect NNS cord-347246-0vofftmj 145 25 of of IN cord-347246-0vofftmj 145 26 natural natural JJ cord-347246-0vofftmj 145 27 disease disease NN cord-347246-0vofftmj 145 28 processes process NNS cord-347246-0vofftmj 145 29 may may MD cord-347246-0vofftmj 145 30 be be VB cord-347246-0vofftmj 145 31 separated separate VBN cord-347246-0vofftmj 145 32 from from IN cord-347246-0vofftmj 145 33 chemically chemically RB cord-347246-0vofftmj 145 34 induced induce VBN cord-347246-0vofftmj 145 35 injury injury NN cord-347246-0vofftmj 145 36 . . . cord-347246-0vofftmj 146 1 Additional additional JJ cord-347246-0vofftmj 146 2 studies study NNS cord-347246-0vofftmj 146 3 are be VBP cord-347246-0vofftmj 146 4 needed need VBN cord-347246-0vofftmj 146 5 to to TO cord-347246-0vofftmj 146 6 assess assess VB cord-347246-0vofftmj 146 7 the the DT cord-347246-0vofftmj 146 8 impact impact NN cord-347246-0vofftmj 146 9 of of IN cord-347246-0vofftmj 146 10 several several JJ cord-347246-0vofftmj 146 11 of of IN cord-347246-0vofftmj 146 12 the the DT cord-347246-0vofftmj 146 13 more more RBR cord-347246-0vofftmj 146 14 prevalent prevalent JJ cord-347246-0vofftmj 146 15 adventitious adventitious JJ cord-347246-0vofftmj 146 16 pathogens pathogen NNS cord-347246-0vofftmj 146 17 on on IN cord-347246-0vofftmj 146 18 the the DT cord-347246-0vofftmj 146 19 results result NNS cord-347246-0vofftmj 146 20 of of IN cord-347246-0vofftmj 146 21 rodent rodent NN cord-347246-0vofftmj 146 22 bioassays bioassay NNS cord-347246-0vofftmj 146 23 . . . cord-347246-0vofftmj 147 1 The the DT cord-347246-0vofftmj 147 2 examination examination NN cord-347246-0vofftmj 147 3 of of IN cord-347246-0vofftmj 147 4 the the DT cord-347246-0vofftmj 147 5 rodent rodent NN cord-347246-0vofftmj 147 6 nasal nasal NN cord-347246-0vofftmj 147 7 cavity cavity NN cord-347246-0vofftmj 147 8 has have VBZ cord-347246-0vofftmj 147 9 been be VBN cord-347246-0vofftmj 147 10 overlooked overlook VBN cord-347246-0vofftmj 147 11 in in IN cord-347246-0vofftmj 147 12 many many JJ cord-347246-0vofftmj 147 13 previous previous JJ cord-347246-0vofftmj 147 14 experimental experimental JJ cord-347246-0vofftmj 147 15 models model NNS cord-347246-0vofftmj 147 16 of of IN cord-347246-0vofftmj 147 17 murine murine JJ cord-347246-0vofftmj 147 18 infectious infectious JJ cord-347246-0vofftmj 147 19 disease disease NN cord-347246-0vofftmj 147 20 . . . cord-347246-0vofftmj 148 1 Descriptive descriptive JJ cord-347246-0vofftmj 148 2 pathology pathology NN cord-347246-0vofftmj 148 3 studies study NNS cord-347246-0vofftmj 148 4 , , , cord-347246-0vofftmj 148 5 which which WDT cord-347246-0vofftmj 148 6 carefully carefully RB cord-347246-0vofftmj 148 7 examine examine VBP cord-347246-0vofftmj 148 8 the the DT cord-347246-0vofftmj 148 9 histogenesis histogenesis NN cord-347246-0vofftmj 148 10 of of IN cord-347246-0vofftmj 148 11 upper upper NNP cord-347246-0vofftmj 148 12 airway airway NN cord-347246-0vofftmj 148 13 injury injury NN cord-347246-0vofftmj 148 14 , , , cord-347246-0vofftmj 148 15 are be VBP cord-347246-0vofftmj 148 16 warranted warrant VBN cord-347246-0vofftmj 148 17 for for IN cord-347246-0vofftmj 148 18 many many JJ cord-347246-0vofftmj 148 19 of of IN cord-347246-0vofftmj 148 20 the the DT cord-347246-0vofftmj 148 21 common common JJ cord-347246-0vofftmj 148 22 pathogens pathogen NNS cord-347246-0vofftmj 148 23 that that WDT cord-347246-0vofftmj 148 24 complicate complicate VBP cord-347246-0vofftmj 148 25 toxicology toxicology NN cord-347246-0vofftmj 148 26 studies study NNS cord-347246-0vofftmj 148 27 . . . cord-347246-0vofftmj 149 1 In in IN cord-347246-0vofftmj 149 2 addition addition NN cord-347246-0vofftmj 149 3 , , , cord-347246-0vofftmj 149 4 the the DT cord-347246-0vofftmj 149 5 effects effect NNS cord-347246-0vofftmj 149 6 of of IN cord-347246-0vofftmj 149 7 murine murine JJ cord-347246-0vofftmj 149 8 infectious infectious JJ cord-347246-0vofftmj 149 9 diseases disease NNS cord-347246-0vofftmj 149 10 on on IN cord-347246-0vofftmj 149 11 xenobiotic xenobiotic JJ cord-347246-0vofftmj 149 12 metabolism metabolism NN cord-347246-0vofftmj 149 13 and and CC cord-347246-0vofftmj 149 14 cytokinetics cytokinetic NNS cord-347246-0vofftmj 149 15 in in IN cord-347246-0vofftmj 149 16 the the DT cord-347246-0vofftmj 149 17 upper upper JJ cord-347246-0vofftmj 149 18 airway airway NN cord-347246-0vofftmj 149 19 should should MD cord-347246-0vofftmj 149 20 be be VB cord-347246-0vofftmj 149 21 further further RB cord-347246-0vofftmj 149 22 investigated investigate VBN cord-347246-0vofftmj 149 23 . . . cord-347246-0vofftmj 150 1 The the DT cord-347246-0vofftmj 150 2 authors author NNS cord-347246-0vofftmj 150 3 wish wish VBP cord-347246-0vofftmj 150 4 to to TO cord-347246-0vofftmj 150 5 thank thank VB cord-347246-0vofftmj 150 6 J. J. NNP cord-347246-0vofftmj 150 7 Griffith Griffith NNP cord-347246-0vofftmj 150 8 for for IN cord-347246-0vofftmj 150 9 slides slide NNS cord-347246-0vofftmj 150 10 of of IN cord-347246-0vofftmj 150 11 CAR car NN cord-347246-0vofftmj 150 12 bacillus bacillus NN cord-347246-0vofftmj 150 13 . . . cord-347246-0vofftmj 150 14 _SP cord-347246-0vofftmj 151 1 Viral viral JJ cord-347246-0vofftmj 151 2 and and CC cord-347246-0vofftmj 151 3 Mycoplasmal Mycoplasmal NNP cord-347246-0vofftmj 151 4 Infections Infections NNPS cord-347246-0vofftmj 151 5 of of IN cord-347246-0vofftmj 151 6 Laboratory Laboratory NNP cord-347246-0vofftmj 151 7 Rodents Rodents NNPS cord-347246-0vofftmj 151 8 : : : cord-347246-0vofftmj 152 1 Effects effect NNS cord-347246-0vofftmj 152 2 on on IN cord-347246-0vofftmj 152 3 Biomedical Biomedical NNP cord-347246-0vofftmj 152 4 Research Research NNP cord-347246-0vofftmj 152 5 Complications Complications NNPS cord-347246-0vofftmj 152 6 of of IN cord-347246-0vofftmj 152 7 Viral Viral NNP cord-347246-0vofftmj 152 8 and and CC cord-347246-0vofftmj 152 9 Mycoplasmal Mycoplasmal NNP cord-347246-0vofftmj 152 10 Infections Infections NNPS cord-347246-0vofftmj 152 11 in in IN cord-347246-0vofftmj 152 12 Rodents rodent NNS cord-347246-0vofftmj 152 13 to to IN cord-347246-0vofftmj 152 14 Toxicology Toxicology NNP cord-347246-0vofftmj 152 15 Research Research NNP cord-347246-0vofftmj 152 16 and and CC cord-347246-0vofftmj 152 17 Testing Testing NNP cord-347246-0vofftmj 152 18 Prevalence prevalence NN cord-347246-0vofftmj 152 19 of of IN cord-347246-0vofftmj 152 20 pathogenic pathogenic JJ cord-347246-0vofftmj 152 21 murine murine JJ cord-347246-0vofftmj 152 22 viruses virus NNS cord-347246-0vofftmj 152 23 and and CC cord-347246-0vofftmj 152 24 mycoplasma mycoplasma NN cord-347246-0vofftmj 152 25 that that WDT cord-347246-0vofftmj 152 26 are be VBP cord-347246-0vofftmj 152 27 currently currently RB cord-347246-0vofftmj 152 28 a a DT cord-347246-0vofftmj 152 29 problem problem NN cord-347246-0vofftmj 152 30 to to TO cord-347246-0vofftmj 152 31 research research VB cord-347246-0vofftmj 152 32 Biology biology NN cord-347246-0vofftmj 152 33 and and CC cord-347246-0vofftmj 152 34 diseases disease NNS cord-347246-0vofftmj 152 35 of of IN cord-347246-0vofftmj 152 36 rats rat NNS cord-347246-0vofftmj 152 37 Pathogenesis Pathogenesis NNP cord-347246-0vofftmj 152 38 of of IN cord-347246-0vofftmj 152 39 sialodacryoadenitis sialodacryoadenitis NNP cord-347246-0vofftmj 152 40 in in IN cord-347246-0vofftmj 152 41 gnotobiotic gnotobiotic JJ cord-347246-0vofftmj 152 42 rats rat NNS cord-347246-0vofftmj 153 1 Sialodacyoadenitis sialodacyoadenitis JJ cord-347246-0vofftmj 153 2 virus virus NN cord-347246-0vofftmj 153 3 infection infection NN cord-347246-0vofftmj 153 4 , , , cord-347246-0vofftmj 153 5 upper upper JJ cord-347246-0vofftmj 153 6 respiratory respiratory JJ cord-347246-0vofftmj 153 7 tract tract NN cord-347246-0vofftmj 153 8 , , , cord-347246-0vofftmj 153 9 rat rat NN cord-347246-0vofftmj 153 10 Comparison comparison NN cord-347246-0vofftmj 153 11 of of IN cord-347246-0vofftmj 153 12 strain strain NN cord-347246-0vofftmj 153 13 susceptibility susceptibility NN cord-347246-0vofftmj 153 14 to to IN cord-347246-0vofftmj 153 15 experimental experimental JJ cord-347246-0vofftmj 153 16 sialodacryoadenitis sialodacryoadenitis NN cord-347246-0vofftmj 153 17 in in IN cord-347246-0vofftmj 153 18 rats rat NNS cord-347246-0vofftmj 153 19 Effects effect NNS cord-347246-0vofftmj 153 20 of of IN cord-347246-0vofftmj 153 21 sialodacryoadenitis sialodacryoadenitis JJ cord-347246-0vofftmj 153 22 virus virus NN cord-347246-0vofftmj 153 23 on on IN cord-347246-0vofftmj 153 24 experimental experimental JJ cord-347246-0vofftmj 153 25 carcinogenesis carcinogenesis NN cord-347246-0vofftmj 153 26 in in IN cord-347246-0vofftmj 153 27 the the DT cord-347246-0vofftmj 153 28 rat rat NN cord-347246-0vofftmj 153 29 ( ( -LRB- cord-347246-0vofftmj 153 30 abstract abstract JJ cord-347246-0vofftmj 153 31 ) ) -RRB- cord-347246-0vofftmj 153 32 Methylene methylene NN cord-347246-0vofftmj 153 33 chloride chloride NN cord-347246-0vofftmj 153 34 : : : cord-347246-0vofftmj 153 35 a a DT cord-347246-0vofftmj 153 36 two two CD cord-347246-0vofftmj 153 37 - - HYPH cord-347246-0vofftmj 153 38 year year NN cord-347246-0vofftmj 153 39 inhalation inhalation NN cord-347246-0vofftmj 153 40 toxicity toxicity NN cord-347246-0vofftmj 153 41 and and CC cord-347246-0vofftmj 153 42 oncogenicity oncogenicity NN cord-347246-0vofftmj 153 43 study study NN cord-347246-0vofftmj 153 44 in in IN cord-347246-0vofftmj 153 45 rats rat NNS cord-347246-0vofftmj 153 46 and and CC cord-347246-0vofftmj 153 47 hamsters hamster NNS cord-347246-0vofftmj 153 48 Sendai Sendai NNP cord-347246-0vofftmj 153 49 virus virus NN cord-347246-0vofftmj 153 50 - - HYPH cord-347246-0vofftmj 153 51 disease disease NN cord-347246-0vofftmj 153 52 processes process NNS cord-347246-0vofftmj 153 53 and and CC cord-347246-0vofftmj 153 54 research research NN cord-347246-0vofftmj 153 55 complications complication NNS cord-347246-0vofftmj 154 1 The the DT cord-347246-0vofftmj 154 2 pathogenesis pathogenesis NN cord-347246-0vofftmj 154 3 of of IN cord-347246-0vofftmj 154 4 Sendai Sendai NNP cord-347246-0vofftmj 154 5 virus virus NN cord-347246-0vofftmj 154 6 infection infection NN cord-347246-0vofftmj 154 7 in in IN cord-347246-0vofftmj 154 8 the the DT cord-347246-0vofftmj 154 9 mouse mouse NN cord-347246-0vofftmj 154 10 lung lung NN cord-347246-0vofftmj 154 11 Susceptibility susceptibility NN cord-347246-0vofftmj 154 12 of of IN cord-347246-0vofftmj 154 13 inbred inbred JJ cord-347246-0vofftmj 154 14 and and CC cord-347246-0vofftmj 154 15 outbred outbred JJ cord-347246-0vofftmj 154 16 mouse mouse NN cord-347246-0vofftmj 154 17 strains strain NNS cord-347246-0vofftmj 154 18 to to IN cord-347246-0vofftmj 154 19 Sendai Sendai NNP cord-347246-0vofftmj 154 20 virus virus NN cord-347246-0vofftmj 154 21 and and CC cord-347246-0vofftmj 154 22 prevalence prevalence NN cord-347246-0vofftmj 154 23 of of IN cord-347246-0vofftmj 154 24 infection infection NN cord-347246-0vofftmj 154 25 in in IN cord-347246-0vofftmj 154 26 laboratory laboratory NN cord-347246-0vofftmj 154 27 rodents rodent NNS cord-347246-0vofftmj 154 28 Naturally naturally RB cord-347246-0vofftmj 154 29 occurring occur VBG cord-347246-0vofftmj 154 30 Sendai Sendai NNP cord-347246-0vofftmj 154 31 virus virus NN cord-347246-0vofftmj 154 32 infection infection NN cord-347246-0vofftmj 154 33 of of IN cord-347246-0vofftmj 154 34 athymic athymic JJ cord-347246-0vofftmj 154 35 nude nude JJ cord-347246-0vofftmj 154 36 mice mouse NNS cord-347246-0vofftmj 154 37 Experimental Experimental NNP cord-347246-0vofftmj 154 38 Sendai Sendai NNP cord-347246-0vofftmj 154 39 virus virus NN cord-347246-0vofftmj 154 40 infection infection NN cord-347246-0vofftmj 154 41 in in IN cord-347246-0vofftmj 154 42 laboratory laboratory NN cord-347246-0vofftmj 154 43 rats rat NNS cord-347246-0vofftmj 154 44 II II NNP cord-347246-0vofftmj 154 45 . . . cord-347246-0vofftmj 155 1 Pathology pathology NN cord-347246-0vofftmj 155 2 and and CC cord-347246-0vofftmj 155 3 immunohistochemistry immunohistochemistry NN cord-347246-0vofftmj 155 4 Sendai Sendai NNP cord-347246-0vofftmj 155 5 virus virus NN cord-347246-0vofftmj 155 6 Influence influence NN cord-347246-0vofftmj 155 7 of of IN cord-347246-0vofftmj 155 8 Sendai Sendai NNP cord-347246-0vofftmj 155 9 virus virus NN cord-347246-0vofftmj 155 10 on on IN cord-347246-0vofftmj 155 11 carcinogenesis carcinogenesis NN cord-347246-0vofftmj 155 12 in in IN cord-347246-0vofftmj 155 13 strain strain NN cord-347246-0vofftmj 155 14 A a DT cord-347246-0vofftmj 155 15 mice mice NN cord-347246-0vofftmj 155 16 Respiratory respiratory JJ cord-347246-0vofftmj 155 17 infections infection NNS cord-347246-0vofftmj 155 18 and and CC cord-347246-0vofftmj 155 19 the the DT cord-347246-0vofftmj 155 20 pathogenesis pathogenesis NN cord-347246-0vofftmj 155 21 of of IN cord-347246-0vofftmj 155 22 lung lung NN cord-347246-0vofftmj 155 23 cancer cancer NN cord-347246-0vofftmj 155 24 . . . cord-347246-0vofftmj 156 1 Recent recent JJ cord-347246-0vofftmj 156 2 Results result NNS cord-347246-0vofftmj 157 1 Cancer cancer NN cord-347246-0vofftmj 157 2 Res Res NNP cord-347246-0vofftmj 157 3 Mycoplasmal Mycoplasmal NNP cord-347246-0vofftmj 157 4 infections infection NNS cord-347246-0vofftmj 157 5 : : : cord-347246-0vofftmj 157 6 disease disease NN cord-347246-0vofftmj 157 7 pathogenesis pathogenesis NN cord-347246-0vofftmj 157 8 , , , cord-347246-0vofftmj 157 9 implications implication NNS cord-347246-0vofftmj 157 10 for for IN cord-347246-0vofftmj 157 11 biomedical biomedical JJ cord-347246-0vofftmj 157 12 research research NN cord-347246-0vofftmj 157 13 , , , cord-347246-0vofftmj 157 14 and and CC cord-347246-0vofftmj 157 15 control control VB cord-347246-0vofftmj 157 16 The the DT cord-347246-0vofftmj 157 17 pathogenic pathogenic JJ cord-347246-0vofftmj 157 18 potential potential NN cord-347246-0vofftmj 157 19 of of IN cord-347246-0vofftmj 157 20 mycoplasmas mycoplasmas NN cord-347246-0vofftmj 157 21 : : : cord-347246-0vofftmj 157 22 Mycoplasma Mycoplasma NNP cord-347246-0vofftmj 157 23 pulmonis pulmonis NNP cord-347246-0vofftmj 157 24 as as IN cord-347246-0vofftmj 157 25 a a DT cord-347246-0vofftmj 157 26 model model NN cord-347246-0vofftmj 157 27 Murine Murine NNP cord-347246-0vofftmj 157 28 respiratory respiratory JJ cord-347246-0vofftmj 157 29 mycoplasmosis mycoplasmosis NN cord-347246-0vofftmj 157 30 , , , cord-347246-0vofftmj 157 31 upper upper JJ cord-347246-0vofftmj 157 32 respiratory respiratory JJ cord-347246-0vofftmj 157 33 tract tract NN cord-347246-0vofftmj 157 34 , , , cord-347246-0vofftmj 157 35 rat rat NN cord-347246-0vofftmj 157 36 Enhancement enhancement NN cord-347246-0vofftmj 157 37 of of IN cord-347246-0vofftmj 157 38 natural natural JJ cord-347246-0vofftmj 157 39 and and CC cord-347246-0vofftmj 157 40 experimental experimental JJ cord-347246-0vofftmj 157 41 respiratory respiratory JJ cord-347246-0vofftmj 157 42 mycoplasmosis mycoplasmosis NN cord-347246-0vofftmj 157 43 in in IN cord-347246-0vofftmj 157 44 rats rat NNS cord-347246-0vofftmj 157 45 by by IN cord-347246-0vofftmj 157 46 hexamethylphosphoramide hexamethylphosphoramide NNP cord-347246-0vofftmj 157 47 Pulmonary pulmonary JJ cord-347246-0vofftmj 157 48 response response NN cord-347246-0vofftmj 157 49 to to IN cord-347246-0vofftmj 157 50 inhaled inhale VBN cord-347246-0vofftmj 157 51 hexamethylphosphoramide hexamethylphosphoramide NN cord-347246-0vofftmj 157 52 in in IN cord-347246-0vofftmj 157 53 rats rat NNS cord-347246-0vofftmj 157 54 Y Y NNP cord-347246-0vofftmj 157 55 Carcinogenic carcinogenic JJ cord-347246-0vofftmj 157 56 and and CC cord-347246-0vofftmj 157 57 toxicologic toxicologic JJ cord-347246-0vofftmj 157 58 effects effect NNS cord-347246-0vofftmj 157 59 of of IN cord-347246-0vofftmj 157 60 inhaled inhale VBN cord-347246-0vofftmj 157 61 ethylene ethylene NN cord-347246-0vofftmj 157 62 oxide oxide NN cord-347246-0vofftmj 157 63 and and CC cord-347246-0vofftmj 157 64 propylene propylene NN cord-347246-0vofftmj 157 65 oxide oxide NN cord-347246-0vofftmj 157 66 in in IN cord-347246-0vofftmj 157 67 F344 f344 JJ cord-347246-0vofftmj 157 68 rats rat NNS cord-347246-0vofftmj 157 69 isolation isolation NN cord-347246-0vofftmj 157 70 , , , cord-347246-0vofftmj 157 71 propagation propagation NN cord-347246-0vofftmj 157 72 , , , cord-347246-0vofftmj 157 73 and and CC cord-347246-0vofftmj 157 74 characterization characterization NN cord-347246-0vofftmj 157 75 of of IN cord-347246-0vofftmj 157 76 a a DT cord-347246-0vofftmj 157 77 newly newly RB cord-347246-0vofftmj 157 78 recognized recognize VBN cord-347246-0vofftmj 157 79 pathogen pathogen NN cord-347246-0vofftmj 157 80 , , , cord-347246-0vofftmj 157 81 cilia cilia NN cord-347246-0vofftmj 157 82 - - HYPH cord-347246-0vofftmj 157 83 associated associate VBN cord-347246-0vofftmj 157 84 respiratory respiratory JJ cord-347246-0vofftmj 157 85 bacillus bacillus NN cord-347246-0vofftmj 157 86 of of IN cord-347246-0vofftmj 157 87 rats rat NNS cord-347246-0vofftmj 157 88 , , , cord-347246-0vofftmj 157 89 an an DT cord-347246-0vofftmj 157 90 etiological etiological JJ cord-347246-0vofftmj 157 91 agent agent NN cord-347246-0vofftmj 157 92 of of IN cord-347246-0vofftmj 157 93 chronic chronic JJ cord-347246-0vofftmj 157 94 respiratory respiratory JJ cord-347246-0vofftmj 157 95 disease disease NN cord-347246-0vofftmj 157 96 Cilia cilia NN cord-347246-0vofftmj 157 97 - - HYPH cord-347246-0vofftmj 157 98 associated associate VBN cord-347246-0vofftmj 157 99 respiratory respiratory NN cord-347246-0vofftmj 157 100 ( ( -LRB- cord-347246-0vofftmj 157 101 CAR car NN cord-347246-0vofftmj 157 102 ) ) -RRB- cord-347246-0vofftmj 157 103 bacillus bacillus NN cord-347246-0vofftmj 157 104 infection infection NN cord-347246-0vofftmj 157 105 of of IN cord-347246-0vofftmj 157 106 obese obese JJ cord-347246-0vofftmj 157 107 mice mouse NNS cord-347246-0vofftmj 157 108 Aspergillus aspergillus NN cord-347246-0vofftmj 157 109 rhinitis rhinitis NN cord-347246-0vofftmj 157 110 in in IN cord-347246-0vofftmj 157 111 Wistar Wistar NNP cord-347246-0vofftmj 157 112 ( ( -LRB- cord-347246-0vofftmj 157 113 Crl:(WI)BR Crl:(WI)BR NNP cord-347246-0vofftmj 157 114 ) ) -RRB- cord-347246-0vofftmj 158 1 rats rat NNS cord-347246-0vofftmj 158 2 Toxicology Toxicology NNP cord-347246-0vofftmj 158 3 : : : cord-347246-0vofftmj 159 1 complications complication NNS cord-347246-0vofftmj 159 2 caused cause VBN cord-347246-0vofftmj 159 3 by by IN cord-347246-0vofftmj 159 4 murine murine JJ cord-347246-0vofftmj 159 5 viruses virus NNS cord-347246-0vofftmj 159 6 and and CC cord-347246-0vofftmj 159 7 mycoplasmas mycoplasmas VB cord-347246-0vofftmj 159 8 The the DT cord-347246-0vofftmj 159 9 influence influence NN cord-347246-0vofftmj 159 10 of of IN cord-347246-0vofftmj 159 11 infection infection NN cord-347246-0vofftmj 159 12 on on IN cord-347246-0vofftmj 159 13 the the DT cord-347246-0vofftmj 159 14 metabolism metabolism NN cord-347246-0vofftmj 159 15 of of IN cord-347246-0vofftmj 159 16 foreign foreign JJ cord-347246-0vofftmj 159 17 compounds compound NNS cord-347246-0vofftmj 160 1 The the DT cord-347246-0vofftmj 160 2 effect effect NN cord-347246-0vofftmj 160 3 of of IN cord-347246-0vofftmj 160 4 cyclophosphamide cyclophosphamide NN cord-347246-0vofftmj 160 5 on on IN cord-347246-0vofftmj 160 6 Sendai Sendai NNP cord-347246-0vofftmj 160 7 virus virus NN cord-347246-0vofftmj 160 8 infection infection NN cord-347246-0vofftmj 160 9 of of IN cord-347246-0vofftmj 160 10 mice mouse NNS cord-347246-0vofftmj 160 11 Effect Effect NNP cord-347246-0vofftmj 160 12 of of IN cord-347246-0vofftmj 160 13 PR-8 PR-8 NNP cord-347246-0vofftmj 160 14 viral viral JJ cord-347246-0vofftmj 160 15 respiratory respiratory JJ cord-347246-0vofftmj 160 16 infection infection NN cord-347246-0vofftmj 160 17 on on IN cord-347246-0vofftmj 160 18 benzo benzo NN cord-347246-0vofftmj 160 19 Possible possible JJ cord-347246-0vofftmj 160 20 consequences consequence NNS cord-347246-0vofftmj 160 21 of of IN cord-347246-0vofftmj 160 22 cytochrome cytochrome NN cord-347246-0vofftmj 160 23 P-450-dependent p-450-dependent NN cord-347246-0vofftmj 160 24 monooxygenases monooxygenase NNS cord-347246-0vofftmj 160 25 in in IN cord-347246-0vofftmj 160 26 nasal nasal NN cord-347246-0vofftmj 160 27 tissues tissue NNS cord-347246-0vofftmj 160 28 Research research NN cord-347246-0vofftmj 160 29 complications complication NNS cord-347246-0vofftmj 160 30 and and CC cord-347246-0vofftmj 160 31 state state NN cord-347246-0vofftmj 160 32 of of IN cord-347246-0vofftmj 160 33 knowledge knowledge NN cord-347246-0vofftmj 160 34 of of IN cord-347246-0vofftmj 160 35 rodent rodent NN cord-347246-0vofftmj 160 36 coronaviruses coronaviruse NNS cord-347246-0vofftmj 160 37 Mouse Mouse NNP cord-347246-0vofftmj 160 38 hepatitis hepatitis NN cord-347246-0vofftmj 160 39 S S NNP cord-347246-0vofftmj 160 40 in in IN cord-347246-0vofftmj 160 41 weanling weanle VBG cord-347246-0vofftmj 160 42 mice mouse NNS cord-347246-0vofftmj 160 43 following follow VBG cord-347246-0vofftmj 160 44 intranasal intranasal NN cord-347246-0vofftmj 160 45 inoculation inoculation NN cord-347246-0vofftmj 161 1 The the DT cord-347246-0vofftmj 161 2 value value NN cord-347246-0vofftmj 161 3 of of IN cord-347246-0vofftmj 161 4 measuring measure VBG cord-347246-0vofftmj 161 5 cell cell NN cord-347246-0vofftmj 161 6 replication replication NN cord-347246-0vofftmj 161 7 as as IN cord-347246-0vofftmj 161 8 a a DT cord-347246-0vofftmj 161 9 predictive predictive JJ cord-347246-0vofftmj 161 10 index index NN cord-347246-0vofftmj 161 11 of of IN cord-347246-0vofftmj 161 12 tissuespecific tissuespecific NNP cord-347246-0vofftmj 161 13 tumorigenic tumorigenic NNP cord-347246-0vofftmj 161 14 potential potential JJ cord-347246-0vofftmj 161 15 Formaldehydeinduced Formaldehydeinduced NNP cord-347246-0vofftmj 161 16 neoplasia neoplasia NN cord-347246-0vofftmj 161 17 , , , cord-347246-0vofftmj 161 18 acute acute JJ cord-347246-0vofftmj 161 19 toxic toxic JJ cord-347246-0vofftmj 161 20 responses response NNS cord-347246-0vofftmj 161 21 and and CC cord-347246-0vofftmj 161 22 cell cell NN cord-347246-0vofftmj 161 23 turnover turnover NN cord-347246-0vofftmj 161 24 in in IN cord-347246-0vofftmj 161 25 the the DT cord-347246-0vofftmj 161 26 nasal nasal NN cord-347246-0vofftmj 161 27 passages passage NNS cord-347246-0vofftmj 161 28 of of IN cord-347246-0vofftmj 161 29 F-344 f-344 NN cord-347246-0vofftmj 161 30 rats rat NNS cord-347246-0vofftmj 161 31 ( ( -LRB- cord-347246-0vofftmj 161 32 abstract abstract JJ cord-347246-0vofftmj 161 33 ) ) -RRB- cord-347246-0vofftmj 162 1 The the DT cord-347246-0vofftmj 162 2 kinetics kinetic NNS cord-347246-0vofftmj 162 3 of of IN cord-347246-0vofftmj 162 4 cell cell NN cord-347246-0vofftmj 162 5 proliferation proliferation NN cord-347246-0vofftmj 162 6 in in IN cord-347246-0vofftmj 162 7 the the DT cord-347246-0vofftmj 162 8 tracheobronchial tracheobronchial JJ cord-347246-0vofftmj 162 9 epithelia epithelium NNS cord-347246-0vofftmj 162 10 of of IN cord-347246-0vofftmj 162 11 rats rat NNS cord-347246-0vofftmj 162 12 with with IN cord-347246-0vofftmj 162 13 and and CC cord-347246-0vofftmj 162 14 without without IN cord-347246-0vofftmj 162 15 chronic chronic JJ cord-347246-0vofftmj 162 16 respiratory respiratory JJ cord-347246-0vofftmj 162 17 disease disease NN cord-347246-0vofftmj 162 18 Photomicrograph Photomicrograph NNP cord-347246-0vofftmj 162 19 of of IN cord-347246-0vofftmj 162 20 the the DT cord-347246-0vofftmj 162 21 nasal nasal NN cord-347246-0vofftmj 162 22 cavity cavity NN cord-347246-0vofftmj 162 23 from from IN cord-347246-0vofftmj 162 24 a a DT cord-347246-0vofftmj 162 25 F344 f344 CD cord-347246-0vofftmj 162 26 rat rat NN cord-347246-0vofftmj 162 27 with with IN cord-347246-0vofftmj 162 28 Aspergillus aspergillus NN cord-347246-0vofftmj 162 29 rhinitis rhinitis NN cord-347246-0vofftmj 162 30 . . . cord-347246-0vofftmj 163 1 The the DT cord-347246-0vofftmj 163 2 respiratory respiratory JJ cord-347246-0vofftmj 163 3 epithelium epithelium NN cord-347246-0vofftmj 163 4 has have VBZ cord-347246-0vofftmj 163 5 early early JJ cord-347246-0vofftmj 163 6 squamous squamous JJ cord-347246-0vofftmj 163 7 metaplasia metaplasia NN cord-347246-0vofftmj 163 8 . . . cord-347246-0vofftmj 164 1 A a DT cord-347246-0vofftmj 164 2 diffuse diffuse JJ cord-347246-0vofftmj 164 3 inflammatory inflammatory JJ cord-347246-0vofftmj 164 4 infiltrate infiltrate NN cord-347246-0vofftmj 164 5 is be VBZ cord-347246-0vofftmj 164 6 present present JJ cord-347246-0vofftmj 164 7 in in IN cord-347246-0vofftmj 164 8 the the DT cord-347246-0vofftmj 164 9 underlying underlie VBG cord-347246-0vofftmj 164 10 lamina lamina NN cord-347246-0vofftmj 164 11 propria propria NN cord-347246-0vofftmj 164 12 . . . cord-347246-0vofftmj 165 1 The the DT cord-347246-0vofftmj 165 2 nasal nasal NN cord-347246-0vofftmj 165 3 cavity cavity NN cord-347246-0vofftmj 165 4 is be VBZ cord-347246-0vofftmj 165 5 filled fill VBN cord-347246-0vofftmj 165 6 with with IN cord-347246-0vofftmj 165 7 debris debris NN cord-347246-0vofftmj 165 8 and and CC cord-347246-0vofftmj 165 9 polymorphonuclear polymorphonuclear NN cord-347246-0vofftmj 165 10 leukocytes leukocyte NNS cord-347246-0vofftmj 165 11 PLATE PLATE NNP cord-347246-0vofftmj 165 12 6 6 CD cord-347246-0vofftmj 165 13 . . . cord-347246-0vofftmj 166 1 Fungal fungal JJ cord-347246-0vofftmj 166 2 hyphae hypha NNS cord-347246-0vofftmj 166 3 within within IN cord-347246-0vofftmj 166 4 nasal nasal NN cord-347246-0vofftmj 166 5 cavity cavity NN cord-347246-0vofftmj 166 6 debris debris NN cord-347246-0vofftmj 166 7 of of IN cord-347246-0vofftmj 166 8 F344 F344 NNS cord-347246-0vofftmj 166 9 rat rat NN cord-347246-0vofftmj 166 10 with with IN cord-347246-0vofftmj 166 11 Aspergillus aspergillus NN cord-347246-0vofftmj 166 12 rhinitis rhinitis NN cord-347246-0vofftmj 166 13 . . . cord-347246-0vofftmj 167 1 Gomori Gomori NNP cord-347246-0vofftmj 167 2 - - HYPH cord-347246-0vofftmj 167 3 methenamine methenamine NN cord-347246-0vofftmj 167 4 silver silver NN