id	sid	tid	token	lemma	pos
cord-345472-qrddwebe	1	1	key	key	JJ
cord-345472-qrddwebe	1	2	:	:	:
cord-345472-qrddwebe	1	3	cord-345472-qrddwebe	cord-345472-qrddwebe	XX
cord-345472-qrddwebe	2	1	authors	author	NNS
cord-345472-qrddwebe	2	2	:	:	:
cord-345472-qrddwebe	2	3	Sebina	Sebina	NNP
cord-345472-qrddwebe	2	4	,	,	,
cord-345472-qrddwebe	2	5	Ismail	Ismail	NNP
cord-345472-qrddwebe	2	6	;	;	:
cord-345472-qrddwebe	2	7	Phipps	Phipps	NNP
cord-345472-qrddwebe	2	8	,	,	,
cord-345472-qrddwebe	2	9	Simon	Simon	NNP
cord-345472-qrddwebe	2	10	title	title	NN
cord-345472-qrddwebe	2	11	:	:	:
cord-345472-qrddwebe	2	12	The	the	DT
cord-345472-qrddwebe	2	13	Contribution	Contribution	NNP
cord-345472-qrddwebe	2	14	of	of	IN
cord-345472-qrddwebe	2	15	Neutrophils	Neutrophils	NNP
cord-345472-qrddwebe	2	16	to	to	IN
cord-345472-qrddwebe	2	17	the	the	DT
cord-345472-qrddwebe	2	18	Pathogenesis	Pathogenesis	NNP
cord-345472-qrddwebe	2	19	of	of	IN
cord-345472-qrddwebe	2	20	RSV	RSV	NNP
cord-345472-qrddwebe	2	21	Bronchiolitis	Bronchiolitis	NNP
cord-345472-qrddwebe	2	22	date	date	NN
cord-345472-qrddwebe	2	23	:	:	:
cord-345472-qrddwebe	2	24	2020	2020	CD
cord-345472-qrddwebe	2	25	-	-	HYPH
cord-345472-qrddwebe	2	26	07	07	CD
cord-345472-qrddwebe	2	27	-	-	HYPH
cord-345472-qrddwebe	2	28	27	27	CD
cord-345472-qrddwebe	2	29	journal	journal	NN
cord-345472-qrddwebe	2	30	:	:	:
cord-345472-qrddwebe	3	1	Viruses	virus	NNS
cord-345472-qrddwebe	3	2	DOI	DOI	NNP
cord-345472-qrddwebe	3	3	:	:	:
cord-345472-qrddwebe	4	1	10.3390/	10.3390/	CD
cord-345472-qrddwebe	5	1	v12080808	v12080808	NNP
cord-345472-qrddwebe	5	2	sha	sha	NNP
cord-345472-qrddwebe	5	3	:	:	:
cord-345472-qrddwebe	5	4	f8f42e5adacd4aaf44e212c5812256caceff9af4	f8f42e5adacd4aaf44e212c5812256caceff9af4	NNP
cord-345472-qrddwebe	5	5	doc_id	doc_id	NNP
cord-345472-qrddwebe	5	6	:	:	:
cord-345472-qrddwebe	5	7	345472	345472	CD
cord-345472-qrddwebe	5	8	cord_uid	cord_uid	NNS
cord-345472-qrddwebe	5	9	:	:	:
cord-345472-qrddwebe	6	1	qrddwebe	qrddwebe	NNP
cord-345472-qrddwebe	6	2	Acute	acute	JJ
cord-345472-qrddwebe	6	3	viral	viral	JJ
cord-345472-qrddwebe	6	4	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	6	5	causes	cause	VBZ
cord-345472-qrddwebe	6	6	significant	significant	JJ
cord-345472-qrddwebe	6	7	mortality	mortality	NN
cord-345472-qrddwebe	6	8	in	in	IN
cord-345472-qrddwebe	6	9	the	the	DT
cord-345472-qrddwebe	6	10	developing	develop	VBG
cord-345472-qrddwebe	6	11	world	world	NN
cord-345472-qrddwebe	6	12	,	,	,
cord-345472-qrddwebe	6	13	is	be	VBZ
cord-345472-qrddwebe	6	14	the	the	DT
cord-345472-qrddwebe	6	15	number	number	NN
cord-345472-qrddwebe	6	16	one	one	CD
cord-345472-qrddwebe	6	17	cause	cause	NN
cord-345472-qrddwebe	6	18	of	of	IN
cord-345472-qrddwebe	6	19	infant	infant	NN
cord-345472-qrddwebe	6	20	hospitalisation	hospitalisation	NN
cord-345472-qrddwebe	6	21	in	in	IN
cord-345472-qrddwebe	6	22	the	the	DT
cord-345472-qrddwebe	6	23	developed	develop	VBN
cord-345472-qrddwebe	6	24	world	world	NN
cord-345472-qrddwebe	6	25	,	,	,
cord-345472-qrddwebe	6	26	and	and	CC
cord-345472-qrddwebe	6	27	is	be	VBZ
cord-345472-qrddwebe	6	28	associated	associate	VBN
cord-345472-qrddwebe	6	29	with	with	IN
cord-345472-qrddwebe	6	30	the	the	DT
cord-345472-qrddwebe	6	31	later	later	JJ
cord-345472-qrddwebe	6	32	development	development	NN
cord-345472-qrddwebe	6	33	of	of	IN
cord-345472-qrddwebe	6	34	chronic	chronic	JJ
cord-345472-qrddwebe	6	35	lung	lung	NN
cord-345472-qrddwebe	6	36	diseases	disease	NNS
cord-345472-qrddwebe	6	37	such	such	JJ
cord-345472-qrddwebe	6	38	as	as	IN
cord-345472-qrddwebe	6	39	asthma	asthma	NN
cord-345472-qrddwebe	6	40	.	.	.
cord-345472-qrddwebe	7	1	A	a	DT
cord-345472-qrddwebe	7	2	vaccine	vaccine	NN
cord-345472-qrddwebe	7	3	against	against	IN
cord-345472-qrddwebe	7	4	respiratory	respiratory	JJ
cord-345472-qrddwebe	7	5	syncytial	syncytial	JJ
cord-345472-qrddwebe	7	6	virus	virus	NN
cord-345472-qrddwebe	7	7	(	(	-LRB-
cord-345472-qrddwebe	7	8	RSV	RSV	NNP
cord-345472-qrddwebe	7	9	)	)	-RRB-
cord-345472-qrddwebe	7	10	,	,	,
cord-345472-qrddwebe	7	11	the	the	DT
cord-345472-qrddwebe	7	12	leading	lead	VBG
cord-345472-qrddwebe	7	13	cause	cause	NN
cord-345472-qrddwebe	7	14	of	of	IN
cord-345472-qrddwebe	7	15	viral	viral	JJ
cord-345472-qrddwebe	7	16	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	7	17	in	in	IN
cord-345472-qrddwebe	7	18	infancy	infancy	NN
cord-345472-qrddwebe	7	19	,	,	,
cord-345472-qrddwebe	7	20	remains	remain	VBZ
cord-345472-qrddwebe	7	21	elusive	elusive	JJ
cord-345472-qrddwebe	7	22	,	,	,
cord-345472-qrddwebe	7	23	and	and	CC
cord-345472-qrddwebe	7	24	hence	hence	RB
cord-345472-qrddwebe	7	25	new	new	JJ
cord-345472-qrddwebe	7	26	therapeutic	therapeutic	JJ
cord-345472-qrddwebe	7	27	modalities	modality	NNS
cord-345472-qrddwebe	7	28	are	be	VBP
cord-345472-qrddwebe	7	29	needed	need	VBN
cord-345472-qrddwebe	7	30	to	to	TO
cord-345472-qrddwebe	7	31	limit	limit	VB
cord-345472-qrddwebe	7	32	disease	disease	NN
cord-345472-qrddwebe	7	33	severity	severity	NN
cord-345472-qrddwebe	7	34	.	.	.
cord-345472-qrddwebe	8	1	However	however	RB
cord-345472-qrddwebe	8	2	,	,	,
cord-345472-qrddwebe	8	3	much	much	RB
cord-345472-qrddwebe	8	4	remains	remain	NNS
cord-345472-qrddwebe	8	5	unknown	unknown	JJ
cord-345472-qrddwebe	8	6	about	about	IN
cord-345472-qrddwebe	8	7	the	the	DT
cord-345472-qrddwebe	8	8	underlying	underlie	VBG
cord-345472-qrddwebe	8	9	pathogenic	pathogenic	JJ
cord-345472-qrddwebe	8	10	mechanisms	mechanism	NNS
cord-345472-qrddwebe	8	11	.	.	.
cord-345472-qrddwebe	9	1	Neutrophilic	Neutrophilic	NNP
cord-345472-qrddwebe	9	2	inflammation	inflammation	NN
cord-345472-qrddwebe	9	3	is	be	VBZ
cord-345472-qrddwebe	9	4	the	the	DT
cord-345472-qrddwebe	9	5	predominant	predominant	JJ
cord-345472-qrddwebe	9	6	phenotype	phenotype	NN
cord-345472-qrddwebe	9	7	observed	observe	VBN
cord-345472-qrddwebe	9	8	in	in	IN
cord-345472-qrddwebe	9	9	infants	infant	NNS
cord-345472-qrddwebe	9	10	with	with	IN
cord-345472-qrddwebe	9	11	both	both	CC
cord-345472-qrddwebe	9	12	mild	mild	JJ
cord-345472-qrddwebe	9	13	and	and	CC
cord-345472-qrddwebe	9	14	severe	severe	JJ
cord-345472-qrddwebe	9	15	disease	disease	NN
cord-345472-qrddwebe	9	16	,	,	,
cord-345472-qrddwebe	9	17	however	however	RB
cord-345472-qrddwebe	9	18	,	,	,
cord-345472-qrddwebe	9	19	a	a	DT
cord-345472-qrddwebe	9	20	clear	clear	JJ
cord-345472-qrddwebe	9	21	understanding	understanding	NN
cord-345472-qrddwebe	9	22	of	of	IN
cord-345472-qrddwebe	9	23	the	the	DT
cord-345472-qrddwebe	9	24	beneficial	beneficial	JJ
cord-345472-qrddwebe	9	25	and	and	CC
cord-345472-qrddwebe	9	26	deleterious	deleterious	JJ
cord-345472-qrddwebe	9	27	effects	effect	NNS
cord-345472-qrddwebe	9	28	of	of	IN
cord-345472-qrddwebe	9	29	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	9	30	is	be	VBZ
cord-345472-qrddwebe	9	31	lacking	lack	VBG
cord-345472-qrddwebe	9	32	.	.	.
cord-345472-qrddwebe	10	1	In	in	IN
cord-345472-qrddwebe	10	2	this	this	DT
cord-345472-qrddwebe	10	3	review	review	NN
cord-345472-qrddwebe	10	4	,	,	,
cord-345472-qrddwebe	10	5	we	-PRON-	PRP
cord-345472-qrddwebe	10	6	describe	describe	VBP
cord-345472-qrddwebe	10	7	the	the	DT
cord-345472-qrddwebe	10	8	multifaceted	multifaceted	JJ
cord-345472-qrddwebe	10	9	roles	role	NNS
cord-345472-qrddwebe	10	10	of	of	IN
cord-345472-qrddwebe	10	11	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	10	12	in	in	IN
cord-345472-qrddwebe	10	13	host	host	NN
cord-345472-qrddwebe	10	14	defence	defence	NN
cord-345472-qrddwebe	10	15	and	and	CC
cord-345472-qrddwebe	10	16	antiviral	antiviral	JJ
cord-345472-qrddwebe	10	17	immunity	immunity	NN
cord-345472-qrddwebe	10	18	,	,	,
cord-345472-qrddwebe	10	19	consider	consider	VB
cord-345472-qrddwebe	10	20	their	-PRON-	PRP$
cord-345472-qrddwebe	10	21	contribution	contribution	NN
cord-345472-qrddwebe	10	22	to	to	IN
cord-345472-qrddwebe	10	23	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	10	24	pathogenesis	pathogenesis	NN
cord-345472-qrddwebe	10	25	,	,	,
cord-345472-qrddwebe	10	26	and	and	CC
cord-345472-qrddwebe	10	27	discuss	discuss	VB
cord-345472-qrddwebe	10	28	whether	whether	IN
cord-345472-qrddwebe	10	29	new	new	JJ
cord-345472-qrddwebe	10	30	approaches	approach	NNS
cord-345472-qrddwebe	10	31	that	that	WDT
cord-345472-qrddwebe	10	32	target	target	VBP
cord-345472-qrddwebe	10	33	neutrophil	neutrophil	NN
cord-345472-qrddwebe	10	34	effector	effector	NN
cord-345472-qrddwebe	10	35	functions	function	NNS
cord-345472-qrddwebe	10	36	will	will	MD
cord-345472-qrddwebe	10	37	be	be	VB
cord-345472-qrddwebe	10	38	suitable	suitable	JJ
cord-345472-qrddwebe	10	39	for	for	IN
cord-345472-qrddwebe	10	40	treating	treat	VBG
cord-345472-qrddwebe	10	41	severe	severe	JJ
cord-345472-qrddwebe	10	42	RSV	RSV	NNP
cord-345472-qrddwebe	10	43	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	10	44	.	.	.
cord-345472-qrddwebe	11	1	Respiratory	respiratory	JJ
cord-345472-qrddwebe	11	2	syncytial	syncytial	JJ
cord-345472-qrddwebe	11	3	virus	virus	NN
cord-345472-qrddwebe	11	4	(	(	-LRB-
cord-345472-qrddwebe	11	5	RSV	RSV	NNP
cord-345472-qrddwebe	11	6	)	)	-RRB-
cord-345472-qrddwebe	11	7	is	be	VBZ
cord-345472-qrddwebe	11	8	the	the	DT
cord-345472-qrddwebe	11	9	leading	lead	VBG
cord-345472-qrddwebe	11	10	viral	viral	JJ
cord-345472-qrddwebe	11	11	cause	cause	NN
cord-345472-qrddwebe	11	12	of	of	IN
cord-345472-qrddwebe	11	13	lower	low	JJR
cord-345472-qrddwebe	11	14	respiratory	respiratory	JJ
cord-345472-qrddwebe	11	15	infections	infection	NNS
cord-345472-qrddwebe	11	16	(	(	-LRB-
cord-345472-qrddwebe	11	17	LRI	LRI	NNP
cord-345472-qrddwebe	11	18	)	)	-RRB-
cord-345472-qrddwebe	11	19	among	among	IN
cord-345472-qrddwebe	11	20	young	young	JJ
cord-345472-qrddwebe	11	21	infants	infant	NNS
cord-345472-qrddwebe	11	22	[	[	-LRB-
cord-345472-qrddwebe	11	23	1	1	CD
cord-345472-qrddwebe	11	24	,	,	,
cord-345472-qrddwebe	11	25	2	2	CD
cord-345472-qrddwebe	11	26	]	]	-RRB-
cord-345472-qrddwebe	11	27	.	.	.
cord-345472-qrddwebe	12	1	In	in	IN
cord-345472-qrddwebe	12	2	2015	2015	CD
cord-345472-qrddwebe	12	3	,	,	,
cord-345472-qrddwebe	12	4	an	an	DT
cord-345472-qrddwebe	12	5	estimated	estimate	VBN
cord-345472-qrddwebe	12	6	33	33	CD
cord-345472-qrddwebe	12	7	million	million	CD
cord-345472-qrddwebe	12	8	cases	case	NNS
cord-345472-qrddwebe	12	9	and	and	CC
cord-345472-qrddwebe	12	10	120,000	120,000	CD
cord-345472-qrddwebe	12	11	deaths	death	NNS
cord-345472-qrddwebe	12	12	due	due	JJ
cord-345472-qrddwebe	12	13	to	to	IN
cord-345472-qrddwebe	12	14	RSV	RSV	NNP
cord-345472-qrddwebe	12	15	infection	infection	NN
cord-345472-qrddwebe	12	16	were	be	VBD
cord-345472-qrddwebe	12	17	reported	report	VBN
cord-345472-qrddwebe	12	18	worldwide	worldwide	RB
cord-345472-qrddwebe	12	19	[	[	-LRB-
cord-345472-qrddwebe	12	20	2	2	CD
cord-345472-qrddwebe	12	21	]	]	-RRB-
cord-345472-qrddwebe	12	22	.	.	.
cord-345472-qrddwebe	13	1	The	the	DT
cord-345472-qrddwebe	13	2	estimated	estimate	VBN
cord-345472-qrddwebe	13	3	cost	cost	NN
cord-345472-qrddwebe	13	4	of	of	IN
cord-345472-qrddwebe	13	5	treating	treat	VBG
cord-345472-qrddwebe	13	6	severe	severe	JJ
cord-345472-qrddwebe	13	7	cases	case	NNS
cord-345472-qrddwebe	13	8	of	of	IN
cord-345472-qrddwebe	13	9	RSV	RSV	NNP
cord-345472-qrddwebe	13	10	-	-	HYPH
cord-345472-qrddwebe	13	11	induced	induce	VBN
cord-345472-qrddwebe	13	12	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	13	13	is	be	VBZ
cord-345472-qrddwebe	13	14	over	over	IN
cord-345472-qrddwebe	13	15	$	$	$
cord-345472-qrddwebe	13	16	300	300	CD
cord-345472-qrddwebe	13	17	million	million	CD
cord-345472-qrddwebe	13	18	per	per	IN
cord-345472-qrddwebe	13	19	year	year	NN
cord-345472-qrddwebe	13	20	[	[	-LRB-
cord-345472-qrddwebe	13	21	3	3	CD
cord-345472-qrddwebe	13	22	]	]	-RRB-
cord-345472-qrddwebe	13	23	,	,	,
cord-345472-qrddwebe	13	24	and	and	CC
cord-345472-qrddwebe	13	25	an	an	DT
cord-345472-qrddwebe	13	26	FDA	FDA	NNP
cord-345472-qrddwebe	13	27	-	-	HYPH
cord-345472-qrddwebe	13	28	approved	approve	VBN
cord-345472-qrddwebe	13	29	vaccine	vaccine	NN
cord-345472-qrddwebe	13	30	against	against	IN
cord-345472-qrddwebe	13	31	RSV	RSV	NNP
cord-345472-qrddwebe	13	32	remains	remain	VBZ
cord-345472-qrddwebe	13	33	elusive	elusive	JJ
cord-345472-qrddwebe	13	34	[	[	-LRB-
cord-345472-qrddwebe	13	35	4	4	CD
cord-345472-qrddwebe	13	36	,	,	,
cord-345472-qrddwebe	13	37	5	5	CD
cord-345472-qrddwebe	13	38	]	]	-RRB-
cord-345472-qrddwebe	13	39	.	.	.
cord-345472-qrddwebe	14	1	A	a	DT
cord-345472-qrddwebe	14	2	greater	great	JJR
cord-345472-qrddwebe	14	3	understanding	understanding	NN
cord-345472-qrddwebe	14	4	of	of	IN
cord-345472-qrddwebe	14	5	the	the	DT
cord-345472-qrddwebe	14	6	molecular	molecular	JJ
cord-345472-qrddwebe	14	7	mechanisms	mechanism	NNS
cord-345472-qrddwebe	14	8	underlying	underlie	VBG
cord-345472-qrddwebe	14	9	the	the	DT
cord-345472-qrddwebe	14	10	immunopathogenesis	immunopathogenesis	NN
cord-345472-qrddwebe	14	11	of	of	IN
cord-345472-qrddwebe	14	12	RSV	RSV	NNP
cord-345472-qrddwebe	14	13	-	-	HYPH
cord-345472-qrddwebe	14	14	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	14	15	may	may	MD
cord-345472-qrddwebe	14	16	reveal	reveal	VB
cord-345472-qrddwebe	14	17	novel	novel	JJ
cord-345472-qrddwebe	14	18	pathways	pathway	NNS
cord-345472-qrddwebe	14	19	that	that	WDT
cord-345472-qrddwebe	14	20	can	can	MD
cord-345472-qrddwebe	14	21	be	be	VB
cord-345472-qrddwebe	14	22	targeted	target	VBN
cord-345472-qrddwebe	14	23	for	for	IN
cord-345472-qrddwebe	14	24	improving	improve	VBG
cord-345472-qrddwebe	14	25	treatment	treatment	NN
cord-345472-qrddwebe	14	26	therapies	therapy	NNS
cord-345472-qrddwebe	14	27	for	for	IN
cord-345472-qrddwebe	14	28	severe	severe	JJ
cord-345472-qrddwebe	14	29	RSV	RSV	NNP
cord-345472-qrddwebe	14	30	patients	patient	NNS
cord-345472-qrddwebe	14	31	.	.	.
cord-345472-qrddwebe	15	1	Severe	severe	JJ
cord-345472-qrddwebe	15	2	viral	viral	JJ
cord-345472-qrddwebe	15	3	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	15	4	in	in	IN
cord-345472-qrddwebe	15	5	infancy	infancy	NN
cord-345472-qrddwebe	15	6	is	be	VBZ
cord-345472-qrddwebe	15	7	a	a	DT
cord-345472-qrddwebe	15	8	major	major	JJ
cord-345472-qrddwebe	15	9	independent	independent	JJ
cord-345472-qrddwebe	15	10	risk	risk	NN
cord-345472-qrddwebe	15	11	factor	factor	NN
cord-345472-qrddwebe	15	12	for	for	IN
cord-345472-qrddwebe	15	13	the	the	DT
cord-345472-qrddwebe	15	14	development	development	NN
cord-345472-qrddwebe	15	15	of	of	IN
cord-345472-qrddwebe	15	16	chronic	chronic	JJ
cord-345472-qrddwebe	15	17	asthma	asthma	NN
cord-345472-qrddwebe	15	18	in	in	IN
cord-345472-qrddwebe	15	19	later	later	JJ
cord-345472-qrddwebe	15	20	life	life	NN
cord-345472-qrddwebe	15	21	[	[	-LRB-
cord-345472-qrddwebe	15	22	6	6	CD
cord-345472-qrddwebe	15	23	]	]	-RRB-
cord-345472-qrddwebe	15	24	.	.	.
cord-345472-qrddwebe	16	1	Therefore	therefore	RB
cord-345472-qrddwebe	16	2	,	,	,
cord-345472-qrddwebe	16	3	ameliorating	ameliorate	VBG
cord-345472-qrddwebe	16	4	severe	severe	JJ
cord-345472-qrddwebe	16	5	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	16	6	in	in	IN
cord-345472-qrddwebe	16	7	infancy	infancy	NN
cord-345472-qrddwebe	16	8	may	may	MD
cord-345472-qrddwebe	16	9	also	also	RB
cord-345472-qrddwebe	16	10	act	act	VB
cord-345472-qrddwebe	16	11	as	as	IN
cord-345472-qrddwebe	16	12	a	a	DT
cord-345472-qrddwebe	16	13	preventative	preventative	JJ
cord-345472-qrddwebe	16	14	strategy	strategy	NN
cord-345472-qrddwebe	16	15	for	for	IN
cord-345472-qrddwebe	16	16	later	later	JJ
cord-345472-qrddwebe	16	17	asthma	asthma	NN
cord-345472-qrddwebe	16	18	in	in	IN
cord-345472-qrddwebe	16	19	susceptible	susceptible	JJ
cord-345472-qrddwebe	16	20	individuals	individual	NNS
cord-345472-qrddwebe	16	21	.	.	.
cord-345472-qrddwebe	17	1	The	the	DT
cord-345472-qrddwebe	17	2	prevailing	prevail	VBG
cord-345472-qrddwebe	17	3	view	view	NN
cord-345472-qrddwebe	17	4	is	be	VBZ
cord-345472-qrddwebe	17	5	that	that	IN
cord-345472-qrddwebe	17	6	severe	severe	JJ
cord-345472-qrddwebe	17	7	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	17	8	results	result	NNS
cord-345472-qrddwebe	17	9	from	from	IN
cord-345472-qrddwebe	17	10	excessive	excessive	JJ
cord-345472-qrddwebe	17	11	inflammation	inflammation	NN
cord-345472-qrddwebe	17	12	and	and	CC
cord-345472-qrddwebe	17	13	consequent	consequent	NN
cord-345472-qrddwebe	17	14	immunopathology	immunopathology	NN
cord-345472-qrddwebe	17	15	,	,	,
cord-345472-qrddwebe	17	16	rather	rather	RB
cord-345472-qrddwebe	17	17	than	than	IN
cord-345472-qrddwebe	17	18	virus	virus	NN
cord-345472-qrddwebe	17	19	-	-	HYPH
cord-345472-qrddwebe	17	20	induced	induce	VBN
cord-345472-qrddwebe	17	21	cytology	cytology	NN
cord-345472-qrddwebe	17	22	.	.	.
cord-345472-qrddwebe	18	1	Neutrophils	neutrophil	NNS
cord-345472-qrddwebe	18	2	are	be	VBP
cord-345472-qrddwebe	18	3	the	the	DT
cord-345472-qrddwebe	18	4	dominant	dominant	JJ
cord-345472-qrddwebe	18	5	inflammatory	inflammatory	JJ
cord-345472-qrddwebe	18	6	cell	cell	NN
cord-345472-qrddwebe	18	7	in	in	IN
cord-345472-qrddwebe	18	8	the	the	DT
cord-345472-qrddwebe	18	9	airways	airway	NNS
cord-345472-qrddwebe	18	10	of	of	IN
cord-345472-qrddwebe	18	11	paediatric	paediatric	JJ
cord-345472-qrddwebe	18	12	patients	patient	NNS
cord-345472-qrddwebe	18	13	with	with	IN
cord-345472-qrddwebe	18	14	RSV	RSV	NNP
cord-345472-qrddwebe	18	15	bronchiolitis	bronchiolitis	NNP
cord-345472-qrddwebe	18	16	[	[	-LRB-
cord-345472-qrddwebe	18	17	7	7	CD
cord-345472-qrddwebe	18	18	]	]	-RRB-
cord-345472-qrddwebe	19	1	[	[	-LRB-
cord-345472-qrddwebe	19	2	8	8	CD
cord-345472-qrddwebe	19	3	]	]	-RRB-
cord-345472-qrddwebe	19	4	[	[	-LRB-
cord-345472-qrddwebe	19	5	9	9	CD
cord-345472-qrddwebe	19	6	]	]	-RRB-
cord-345472-qrddwebe	19	7	,	,	,
cord-345472-qrddwebe	19	8	accounting	account	VBG
cord-345472-qrddwebe	19	9	for	for	IN
cord-345472-qrddwebe	19	10	up	up	IN
cord-345472-qrddwebe	19	11	to	to	TO
cord-345472-qrddwebe	19	12	80	80	CD
cord-345472-qrddwebe	19	13	%	%	NN
cord-345472-qrddwebe	19	14	of	of	IN
cord-345472-qrddwebe	19	15	the	the	DT
cord-345472-qrddwebe	19	16	cellular	cellular	JJ
cord-345472-qrddwebe	19	17	infiltrate	infiltrate	NN
cord-345472-qrddwebe	19	18	at	at	IN
cord-345472-qrddwebe	19	19	peak	peak	NN
cord-345472-qrddwebe	19	20	symptomatology	symptomatology	NN
cord-345472-qrddwebe	19	21	[	[	-LRB-
cord-345472-qrddwebe	19	22	8	8	CD
cord-345472-qrddwebe	19	23	]	]	-RRB-
cord-345472-qrddwebe	19	24	,	,	,
cord-345472-qrddwebe	19	25	and	and	CC
cord-345472-qrddwebe	19	26	yet	yet	RB
cord-345472-qrddwebe	19	27	the	the	DT
cord-345472-qrddwebe	19	28	precise	precise	JJ
cord-345472-qrddwebe	19	29	contribution	contribution	NN
cord-345472-qrddwebe	19	30	of	of	IN
cord-345472-qrddwebe	19	31	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	19	32	to	to	IN
cord-345472-qrddwebe	19	33	antiviral	antiviral	JJ
cord-345472-qrddwebe	19	34	immunity	immunity	NN
cord-345472-qrddwebe	19	35	remains	remain	VBZ
cord-345472-qrddwebe	19	36	ill	ill	RB
cord-345472-qrddwebe	19	37	-	-	HYPH
cord-345472-qrddwebe	19	38	defined	define	VBN
cord-345472-qrddwebe	19	39	.	.	.
cord-345472-qrddwebe	20	1	In	in	IN
cord-345472-qrddwebe	20	2	the	the	DT
cord-345472-qrddwebe	20	3	context	context	NN
cord-345472-qrddwebe	20	4	of	of	IN
cord-345472-qrddwebe	20	5	anti	anti	JJ
cord-345472-qrddwebe	20	6	-	-	JJ
cord-345472-qrddwebe	20	7	bacterial	bacterial	JJ
cord-345472-qrddwebe	20	8	or	or	CC
cord-345472-qrddwebe	20	9	anti	anti	JJ
cord-345472-qrddwebe	20	10	-	-	JJ
cord-345472-qrddwebe	20	11	fungal	fungal	JJ
cord-345472-qrddwebe	20	12	immunity	immunity	NN
cord-345472-qrddwebe	20	13	,	,	,
cord-345472-qrddwebe	20	14	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	20	15	mediate	mediate	VBP
cord-345472-qrddwebe	20	16	protection	protection	NN
cord-345472-qrddwebe	20	17	through	through	IN
cord-345472-qrddwebe	20	18	the	the	DT
cord-345472-qrddwebe	20	19	production	production	NN
cord-345472-qrddwebe	20	20	of	of	IN
cord-345472-qrddwebe	20	21	antimicrobial	antimicrobial	JJ
cord-345472-qrddwebe	20	22	peptides	peptide	NNS
cord-345472-qrddwebe	20	23	,	,	,
cord-345472-qrddwebe	20	24	respiratory	respiratory	JJ
cord-345472-qrddwebe	20	25	oxygen	oxygen	NN
cord-345472-qrddwebe	20	26	species	specie	NNS
cord-345472-qrddwebe	20	27	(	(	-LRB-
cord-345472-qrddwebe	20	28	ROS	ROS	NNP
cord-345472-qrddwebe	20	29	)	)	-RRB-
cord-345472-qrddwebe	20	30	,	,	,
cord-345472-qrddwebe	20	31	cytokines	cytokine	NNS
cord-345472-qrddwebe	20	32	and	and	CC
cord-345472-qrddwebe	20	33	chemokines	chemokine	NNS
cord-345472-qrddwebe	20	34	,	,	,
cord-345472-qrddwebe	20	35	and	and	CC
cord-345472-qrddwebe	20	36	the	the	DT
cord-345472-qrddwebe	20	37	formation	formation	NN
cord-345472-qrddwebe	20	38	of	of	IN
cord-345472-qrddwebe	20	39	neutrophil	neutrophil	NN
cord-345472-qrddwebe	20	40	extracellular	extracellular	JJ
cord-345472-qrddwebe	20	41	traps	trap	NNS
cord-345472-qrddwebe	20	42	(	(	-LRB-
cord-345472-qrddwebe	20	43	NETs	nets	NN
cord-345472-qrddwebe	20	44	)	)	-RRB-
cord-345472-qrddwebe	20	45	.	.	.
cord-345472-qrddwebe	21	1	New	new	JJ
cord-345472-qrddwebe	21	2	information	information	NN
cord-345472-qrddwebe	21	3	from	from	IN
cord-345472-qrddwebe	21	4	omics	omic	NNS
cord-345472-qrddwebe	21	5	-	-	HYPH
cord-345472-qrddwebe	21	6	based	base	VBN
cord-345472-qrddwebe	21	7	technologies	technology	NNS
cord-345472-qrddwebe	21	8	and	and	CC
cord-345472-qrddwebe	21	9	advances	advance	NNS
cord-345472-qrddwebe	21	10	in	in	IN
cord-345472-qrddwebe	21	11	multi	multi	JJ
cord-345472-qrddwebe	21	12	-	-	JJ
cord-345472-qrddwebe	21	13	parameter	parameter	NN
cord-345472-qrddwebe	21	14	flow	flow	NN
cord-345472-qrddwebe	21	15	cytometry	cytometry	NN
cord-345472-qrddwebe	21	16	are	be	VBP
cord-345472-qrddwebe	21	17	shedding	shed	VBG
cord-345472-qrddwebe	21	18	new	new	JJ
cord-345472-qrddwebe	21	19	light	light	NN
cord-345472-qrddwebe	21	20	on	on	IN
cord-345472-qrddwebe	21	21	neutrophil	neutrophil	NN
cord-345472-qrddwebe	21	22	diversity	diversity	NN
cord-345472-qrddwebe	21	23	and	and	CC
cord-345472-qrddwebe	21	24	function	function	NN
cord-345472-qrddwebe	21	25	,	,	,
cord-345472-qrddwebe	21	26	suggesting	suggest	VBG
cord-345472-qrddwebe	21	27	a	a	DT
cord-345472-qrddwebe	21	28	greater	great	JJR
cord-345472-qrddwebe	21	29	complexity	complexity	NN
cord-345472-qrddwebe	21	30	to	to	IN
cord-345472-qrddwebe	21	31	a	a	DT
cord-345472-qrddwebe	21	32	cell	cell	NN
cord-345472-qrddwebe	21	33	that	that	WDT
cord-345472-qrddwebe	21	34	is	be	VBZ
cord-345472-qrddwebe	21	35	often	often	RB
cord-345472-qrddwebe	21	36	unfavourably	unfavourably	RB
cord-345472-qrddwebe	21	37	viewed	view	VBN
cord-345472-qrddwebe	21	38	as	as	IN
cord-345472-qrddwebe	21	39	a	a	DT
cord-345472-qrddwebe	21	40	blunt	blunt	JJ
cord-345472-qrddwebe	21	41	tool	tool	NN
cord-345472-qrddwebe	21	42	on	on	IN
cord-345472-qrddwebe	21	43	account	account	NN
cord-345472-qrddwebe	21	44	of	of	IN
cord-345472-qrddwebe	21	45	its	-PRON-	PRP$
cord-345472-qrddwebe	21	46	spectacular	spectacular	JJ
cord-345472-qrddwebe	21	47	prowess	prowess	NN
cord-345472-qrddwebe	21	48	at	at	IN
cord-345472-qrddwebe	21	49	microbial	microbial	JJ
cord-345472-qrddwebe	21	50	killing	killing	NN
cord-345472-qrddwebe	21	51	and	and	CC
cord-345472-qrddwebe	21	52	short	short	JJ
cord-345472-qrddwebe	21	53	life	life	NN
cord-345472-qrddwebe	21	54	-	-	HYPH
cord-345472-qrddwebe	21	55	span	span	NN
cord-345472-qrddwebe	21	56	.	.	.
cord-345472-qrddwebe	22	1	Here	here	RB
cord-345472-qrddwebe	22	2	,	,	,
cord-345472-qrddwebe	22	3	we	-PRON-	PRP
cord-345472-qrddwebe	22	4	review	review	VBP
cord-345472-qrddwebe	22	5	the	the	DT
cord-345472-qrddwebe	22	6	multifaceted	multifaceted	JJ
cord-345472-qrddwebe	22	7	roles	role	NNS
cord-345472-qrddwebe	22	8	of	of	IN
cord-345472-qrddwebe	22	9	the	the	DT
cord-345472-qrddwebe	22	10	neutrophil	neutrophil	NN
cord-345472-qrddwebe	22	11	in	in	IN
cord-345472-qrddwebe	22	12	host	host	NN
cord-345472-qrddwebe	22	13	defence	defence	NN
cord-345472-qrddwebe	22	14	,	,	,
cord-345472-qrddwebe	22	15	antiviral	antiviral	JJ
cord-345472-qrddwebe	22	16	immunity	immunity	NN
cord-345472-qrddwebe	22	17	,	,	,
cord-345472-qrddwebe	22	18	and	and	CC
cord-345472-qrddwebe	22	19	immunopathogenesis	immunopathogenesis	NN
cord-345472-qrddwebe	22	20	in	in	IN
cord-345472-qrddwebe	22	21	the	the	DT
cord-345472-qrddwebe	22	22	context	context	NN
cord-345472-qrddwebe	22	23	of	of	IN
cord-345472-qrddwebe	22	24	viral	viral	JJ
cord-345472-qrddwebe	22	25	LRIs	lri	NNS
cord-345472-qrddwebe	22	26	.	.	.
cord-345472-qrddwebe	23	1	We	-PRON-	PRP
cord-345472-qrddwebe	23	2	find	find	VBP
cord-345472-qrddwebe	23	3	that	that	IN
cord-345472-qrddwebe	23	4	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	23	5	make	make	VBP
cord-345472-qrddwebe	23	6	an	an	DT
cord-345472-qrddwebe	23	7	important	important	JJ
cord-345472-qrddwebe	23	8	contribution	contribution	NN
cord-345472-qrddwebe	23	9	to	to	TO
cord-345472-qrddwebe	23	10	innate	innate	VB
cord-345472-qrddwebe	23	11	antiviral	antiviral	JJ
cord-345472-qrddwebe	23	12	immunity	immunity	NN
cord-345472-qrddwebe	23	13	and	and	CC
cord-345472-qrddwebe	23	14	help	help	NN
cord-345472-qrddwebe	23	15	to	to	TO
cord-345472-qrddwebe	23	16	optimise	optimise	VB
cord-345472-qrddwebe	23	17	the	the	DT
cord-345472-qrddwebe	23	18	induction	induction	NN
cord-345472-qrddwebe	23	19	of	of	IN
cord-345472-qrddwebe	23	20	an	an	DT
cord-345472-qrddwebe	23	21	effective	effective	JJ
cord-345472-qrddwebe	23	22	adaptive	adaptive	JJ
cord-345472-qrddwebe	23	23	immune	immune	JJ
cord-345472-qrddwebe	23	24	response	response	NN
cord-345472-qrddwebe	23	25	.	.	.
cord-345472-qrddwebe	24	1	However	however	RB
cord-345472-qrddwebe	24	2	,	,	,
cord-345472-qrddwebe	24	3	as	as	IN
cord-345472-qrddwebe	24	4	a	a	DT
cord-345472-qrddwebe	24	5	consequence	consequence	NN
cord-345472-qrddwebe	24	6	of	of	IN
cord-345472-qrddwebe	24	7	their	-PRON-	PRP$
cord-345472-qrddwebe	24	8	ability	ability	NN
cord-345472-qrddwebe	24	9	to	to	TO
cord-345472-qrddwebe	24	10	initiate	initiate	VB
cord-345472-qrddwebe	24	11	and	and	CC
cord-345472-qrddwebe	24	12	amplify	amplify	VB
cord-345472-qrddwebe	24	13	the	the	DT
cord-345472-qrddwebe	24	14	magnitude	magnitude	NN
cord-345472-qrddwebe	24	15	of	of	IN
cord-345472-qrddwebe	24	16	an	an	DT
cord-345472-qrddwebe	24	17	inflammatory	inflammatory	JJ
cord-345472-qrddwebe	24	18	reaction	reaction	NN
cord-345472-qrddwebe	24	19	,	,	,
cord-345472-qrddwebe	24	20	it	-PRON-	PRP
cord-345472-qrddwebe	24	21	is	be	VBZ
cord-345472-qrddwebe	24	22	clear	clear	JJ
cord-345472-qrddwebe	24	23	that	that	IN
cord-345472-qrddwebe	24	24	a	a	DT
cord-345472-qrddwebe	24	25	failure	failure	NN
cord-345472-qrddwebe	24	26	to	to	TO
cord-345472-qrddwebe	24	27	adequately	adequately	RB
cord-345472-qrddwebe	24	28	regulate	regulate	VB
cord-345472-qrddwebe	24	29	this	this	DT
cord-345472-qrddwebe	24	30	response	response	NN
cord-345472-qrddwebe	24	31	can	can	MD
cord-345472-qrddwebe	24	32	lead	lead	VB
cord-345472-qrddwebe	24	33	to	to	IN
cord-345472-qrddwebe	24	34	excessive	excessive	JJ
cord-345472-qrddwebe	24	35	collateral	collateral	JJ
cord-345472-qrddwebe	24	36	damage	damage	NN
cord-345472-qrddwebe	24	37	and	and	CC
cord-345472-qrddwebe	24	38	a	a	DT
cord-345472-qrddwebe	24	39	loss	loss	NN
cord-345472-qrddwebe	24	40	of	of	IN
cord-345472-qrddwebe	24	41	tissue	tissue	NN
cord-345472-qrddwebe	24	42	function	function	NN
cord-345472-qrddwebe	24	43	,	,	,
cord-345472-qrddwebe	24	44	leading	lead	VBG
cord-345472-qrddwebe	24	45	to	to	IN
cord-345472-qrddwebe	24	46	significant	significant	JJ
cord-345472-qrddwebe	24	47	morbidity	morbidity	NN
cord-345472-qrddwebe	24	48	from	from	IN
cord-345472-qrddwebe	24	49	an	an	DT
cord-345472-qrddwebe	24	50	RSV	RSV	NNP
cord-345472-qrddwebe	24	51	infection	infection	NN
cord-345472-qrddwebe	24	52	.	.	.
cord-345472-qrddwebe	25	1	We	-PRON-	PRP
cord-345472-qrddwebe	25	2	consider	consider	VBP
cord-345472-qrddwebe	25	3	a	a	DT
cord-345472-qrddwebe	25	4	number	number	NN
cord-345472-qrddwebe	25	5	of	of	IN
cord-345472-qrddwebe	25	6	novel	novel	JJ
cord-345472-qrddwebe	25	7	approaches	approach	NNS
cord-345472-qrddwebe	25	8	that	that	WDT
cord-345472-qrddwebe	25	9	might	may	MD
cord-345472-qrddwebe	25	10	be	be	VB
cord-345472-qrddwebe	25	11	employed	employ	VBN
cord-345472-qrddwebe	25	12	to	to	IN
cord-345472-qrddwebe	25	13	either	either	DT
cord-345472-qrddwebe	25	14	harness	harness	VB
cord-345472-qrddwebe	25	15	or	or	CC
cord-345472-qrddwebe	25	16	suppress	suppress	VB
cord-345472-qrddwebe	25	17	the	the	DT
cord-345472-qrddwebe	25	18	actions	action	NNS
cord-345472-qrddwebe	25	19	of	of	IN
cord-345472-qrddwebe	25	20	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	25	21	to	to	TO
cord-345472-qrddwebe	25	22	promote	promote	VB
cord-345472-qrddwebe	25	23	antiviral	antiviral	JJ
cord-345472-qrddwebe	25	24	immunity	immunity	NN
cord-345472-qrddwebe	25	25	and/or	and/or	CC
cord-345472-qrddwebe	25	26	ameliorate	ameliorate	VB
cord-345472-qrddwebe	25	27	the	the	DT
cord-345472-qrddwebe	25	28	immunopathology	immunopathology	NN
cord-345472-qrddwebe	25	29	associated	associate	VBN
cord-345472-qrddwebe	25	30	with	with	IN
cord-345472-qrddwebe	25	31	severe	severe	JJ
cord-345472-qrddwebe	25	32	RSV	RSV	NNP
cord-345472-qrddwebe	25	33	infection	infection	NN
cord-345472-qrddwebe	25	34	.	.	.
cord-345472-qrddwebe	26	1	An	an	DT
cord-345472-qrddwebe	26	2	estimated	estimate	VBN
cord-345472-qrddwebe	26	3	four	four	CD
cord-345472-qrddwebe	26	4	billion	billion	CD
cord-345472-qrddwebe	26	5	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	26	6	are	be	VBP
cord-345472-qrddwebe	26	7	produced	produce	VBN
cord-345472-qrddwebe	26	8	in	in	IN
cord-345472-qrddwebe	26	9	the	the	DT
cord-345472-qrddwebe	26	10	bone	bone	NN
cord-345472-qrddwebe	26	11	marrow	marrow	NN
cord-345472-qrddwebe	26	12	every	every	DT
cord-345472-qrddwebe	26	13	hour	hour	NN
cord-345472-qrddwebe	26	14	[	[	-LRB-
cord-345472-qrddwebe	26	15	10	10	CD
cord-345472-qrddwebe	26	16	,	,	,
cord-345472-qrddwebe	26	17	11	11	CD
cord-345472-qrddwebe	26	18	]	]	-RRB-
cord-345472-qrddwebe	26	19	,	,	,
cord-345472-qrddwebe	26	20	and	and	CC
cord-345472-qrddwebe	26	21	accordingly	accordingly	RB
cord-345472-qrddwebe	26	22	,	,	,
cord-345472-qrddwebe	26	23	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	26	24	are	be	VBP
cord-345472-qrddwebe	26	25	by	by	IN
cord-345472-qrddwebe	26	26	far	far	RB
cord-345472-qrddwebe	26	27	the	the	DT
cord-345472-qrddwebe	26	28	most	most	RBS
cord-345472-qrddwebe	26	29	abundant	abundant	JJ
cord-345472-qrddwebe	26	30	leukocyte	leukocyte	NN
cord-345472-qrddwebe	26	31	in	in	IN
cord-345472-qrddwebe	26	32	blood	blood	NN
cord-345472-qrddwebe	26	33	,	,	,
cord-345472-qrddwebe	26	34	representing	represent	VBG
cord-345472-qrddwebe	26	35	approximately	approximately	RB
cord-345472-qrddwebe	26	36	60	60	CD
cord-345472-qrddwebe	26	37	%	%	NN
cord-345472-qrddwebe	26	38	of	of	IN
cord-345472-qrddwebe	26	39	the	the	DT
cord-345472-qrddwebe	26	40	total	total	JJ
cord-345472-qrddwebe	26	41	white	white	JJ
cord-345472-qrddwebe	26	42	blood	blood	NN
cord-345472-qrddwebe	26	43	cell	cell	NN
cord-345472-qrddwebe	26	44	count	count	NN
cord-345472-qrddwebe	26	45	.	.	.
cord-345472-qrddwebe	27	1	As	as	RB
cord-345472-qrddwebe	27	2	well	well	RB
cord-345472-qrddwebe	27	3	as	as	IN
cord-345472-qrddwebe	27	4	circulating	circulate	VBG
cord-345472-qrddwebe	27	5	in	in	IN
cord-345472-qrddwebe	27	6	large	large	JJ
cord-345472-qrddwebe	27	7	numbers	number	NNS
cord-345472-qrddwebe	27	8	,	,	,
cord-345472-qrddwebe	27	9	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	27	10	enter	enter	VBP
cord-345472-qrddwebe	27	11	and	and	CC
cord-345472-qrddwebe	27	12	surveil	surveil	VBP
cord-345472-qrddwebe	27	13	tissues	tissue	NNS
cord-345472-qrddwebe	27	14	in	in	IN
cord-345472-qrddwebe	27	15	the	the	DT
cord-345472-qrddwebe	27	16	steady	steady	JJ
cord-345472-qrddwebe	27	17	state	state	NN
cord-345472-qrddwebe	27	18	[	[	-LRB-
cord-345472-qrddwebe	27	19	11	11	CD
cord-345472-qrddwebe	27	20	]	]	-RRB-
cord-345472-qrddwebe	27	21	.	.	.
cord-345472-qrddwebe	28	1	Neutrophils	neutrophil	NNS
cord-345472-qrddwebe	28	2	are	be	VBP
cord-345472-qrddwebe	28	3	one	one	CD
cord-345472-qrddwebe	28	4	of	of	IN
cord-345472-qrddwebe	28	5	the	the	DT
cord-345472-qrddwebe	28	6	host	host	NN
cord-345472-qrddwebe	28	7	's	's	POS
cord-345472-qrddwebe	28	8	first	first	JJ
cord-345472-qrddwebe	28	9	defensive	defensive	JJ
cord-345472-qrddwebe	28	10	measures	measure	NNS
cord-345472-qrddwebe	28	11	against	against	IN
cord-345472-qrddwebe	28	12	a	a	DT
cord-345472-qrddwebe	28	13	sterile	sterile	JJ
cord-345472-qrddwebe	28	14	or	or	CC
cord-345472-qrddwebe	28	15	microbial	microbial	JJ
cord-345472-qrddwebe	28	16	insult	insult	NN
cord-345472-qrddwebe	28	17	.	.	.
cord-345472-qrddwebe	29	1	Neutrophils	neutrophil	NNS
cord-345472-qrddwebe	29	2	employ	employ	VBP
cord-345472-qrddwebe	29	3	three	three	CD
cord-345472-qrddwebe	29	4	major	major	JJ
cord-345472-qrddwebe	29	5	defensive	defensive	JJ
cord-345472-qrddwebe	29	6	mechanisms	mechanism	NNS
cord-345472-qrddwebe	29	7	:	:	:
cord-345472-qrddwebe	29	8	phagocytosis	phagocytosis	NN
cord-345472-qrddwebe	29	9	,	,	,
cord-345472-qrddwebe	29	10	degranulation	degranulation	NN
cord-345472-qrddwebe	29	11	(	(	-LRB-
cord-345472-qrddwebe	29	12	secreting	secrete	VBG
cord-345472-qrddwebe	29	13	an	an	DT
cord-345472-qrddwebe	29	14	array	array	NN
cord-345472-qrddwebe	29	15	of	of	IN
cord-345472-qrddwebe	29	16	anti	anti	JJ
cord-345472-qrddwebe	29	17	-	-	JJ
cord-345472-qrddwebe	29	18	microbial	microbial	JJ
cord-345472-qrddwebe	29	19	peptides	peptide	NNS
cord-345472-qrddwebe	29	20	)	)	-RRB-
cord-345472-qrddwebe	29	21	,	,	,
cord-345472-qrddwebe	29	22	and	and	CC
cord-345472-qrddwebe	29	23	NETosis	NETosis	NNP
cord-345472-qrddwebe	29	24	[	[	-LRB-
cord-345472-qrddwebe	29	25	12	12	CD
cord-345472-qrddwebe	29	26	,	,	,
cord-345472-qrddwebe	29	27	13	13	CD
cord-345472-qrddwebe	29	28	]	]	-RRB-
cord-345472-qrddwebe	29	29	.	.	.
cord-345472-qrddwebe	30	1	During	during	IN
cord-345472-qrddwebe	30	2	phagocytosis	phagocytosis	NN
cord-345472-qrddwebe	30	3	,	,	,
cord-345472-qrddwebe	30	4	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	30	5	utilise	utilise	VBP
cord-345472-qrddwebe	30	6	a	a	DT
cord-345472-qrddwebe	30	7	combination	combination	NN
cord-345472-qrddwebe	30	8	of	of	IN
cord-345472-qrddwebe	30	9	surface	surface	NN
cord-345472-qrddwebe	30	10	-	-	HYPH
cord-345472-qrddwebe	30	11	expressed	express	VBN
cord-345472-qrddwebe	30	12	opsonic	opsonic	JJ
cord-345472-qrddwebe	30	13	receptors	receptor	NNS
cord-345472-qrddwebe	30	14	,	,	,
cord-345472-qrddwebe	30	15	intracellular	intracellular	JJ
cord-345472-qrddwebe	30	16	signalling	signal	VBG
cord-345472-qrddwebe	30	17	cascades	cascade	NNS
cord-345472-qrddwebe	30	18	,	,	,
cord-345472-qrddwebe	30	19	and	and	CC
cord-345472-qrddwebe	30	20	cytoskeletal	cytoskeletal	JJ
cord-345472-qrddwebe	30	21	rearrangements	rearrangement	NNS
cord-345472-qrddwebe	30	22	to	to	TO
cord-345472-qrddwebe	30	23	engulf	engulf	VB
cord-345472-qrddwebe	30	24	and	and	CC
cord-345472-qrddwebe	30	25	internalise	internalise	VB
cord-345472-qrddwebe	30	26	microbes	microbe	NNS
cord-345472-qrddwebe	30	27	[	[	-LRB-
cord-345472-qrddwebe	30	28	14	14	CD
cord-345472-qrddwebe	30	29	,	,	,
cord-345472-qrddwebe	30	30	15	15	CD
cord-345472-qrddwebe	30	31	]	]	-RRB-
cord-345472-qrddwebe	30	32	.	.	.
cord-345472-qrddwebe	31	1	Neutrophils	neutrophil	NNS
cord-345472-qrddwebe	31	2	contain	contain	VBP
cord-345472-qrddwebe	31	3	cytoplasmic	cytoplasmic	JJ
cord-345472-qrddwebe	31	4	granules	granule	NNS
cord-345472-qrddwebe	31	5	,	,	,
cord-345472-qrddwebe	31	6	which	which	WDT
cord-345472-qrddwebe	31	7	store	store	VBP
cord-345472-qrddwebe	31	8	antimicrobial	antimicrobial	JJ
cord-345472-qrddwebe	31	9	molecules	molecule	NNS
cord-345472-qrddwebe	31	10	and	and	CC
cord-345472-qrddwebe	31	11	facilitate	facilitate	VB
cord-345472-qrddwebe	31	12	cross	cross	NN
cord-345472-qrddwebe	31	13	-	-	NN
cord-345472-qrddwebe	31	14	talk	talk	NN
cord-345472-qrddwebe	31	15	with	with	IN
cord-345472-qrddwebe	31	16	other	other	JJ
cord-345472-qrddwebe	31	17	immune	immune	JJ
cord-345472-qrddwebe	31	18	cells	cell	NNS
cord-345472-qrddwebe	31	19	[	[	-LRB-
cord-345472-qrddwebe	31	20	16	16	CD
cord-345472-qrddwebe	31	21	]	]	-RRB-
cord-345472-qrddwebe	31	22	.	.	.
cord-345472-qrddwebe	32	1	These	these	DT
cord-345472-qrddwebe	32	2	granules	granule	NNS
cord-345472-qrddwebe	32	3	(	(	-LRB-
cord-345472-qrddwebe	32	4	summarised	summarise	VBN
cord-345472-qrddwebe	32	5	in	in	IN
cord-345472-qrddwebe	32	6	Table	Table	NNP
cord-345472-qrddwebe	32	7	1	1	CD
cord-345472-qrddwebe	32	8	)	)	-RRB-
cord-345472-qrddwebe	32	9	are	be	VBP
cord-345472-qrddwebe	32	10	subdivided	subdivide	VBN
cord-345472-qrddwebe	32	11	into	into	IN
cord-345472-qrddwebe	32	12	primary	primary	JJ
cord-345472-qrddwebe	32	13	or	or	CC
cord-345472-qrddwebe	32	14	azurophilic	azurophilic	JJ
cord-345472-qrddwebe	32	15	granules	granule	NNS
cord-345472-qrddwebe	32	16	(	(	-LRB-
cord-345472-qrddwebe	32	17	containing	contain	VBG
cord-345472-qrddwebe	32	18	,	,	,
cord-345472-qrddwebe	32	19	e.g.	e.g.	RB
cord-345472-qrddwebe	32	20	,	,	,
cord-345472-qrddwebe	32	21	myeloperoxidase	myeloperoxidase	NN
cord-345472-qrddwebe	32	22	,	,	,
cord-345472-qrddwebe	32	23	CD63	CD63	NNP
cord-345472-qrddwebe	32	24	)	)	-RRB-
cord-345472-qrddwebe	32	25	,	,	,
cord-345472-qrddwebe	32	26	secondary	secondary	JJ
cord-345472-qrddwebe	32	27	or	or	CC
cord-345472-qrddwebe	32	28	specific	specific	JJ
cord-345472-qrddwebe	32	29	granules	granule	NNS
cord-345472-qrddwebe	32	30	(	(	-LRB-
cord-345472-qrddwebe	32	31	containing	contain	VBG
cord-345472-qrddwebe	32	32	,	,	,
cord-345472-qrddwebe	32	33	e.g.	e.g.	RB
cord-345472-qrddwebe	32	34	,	,	,
cord-345472-qrddwebe	32	35	lipocalin-2	lipocalin-2	NNP
cord-345472-qrddwebe	32	36	and	and	CC
cord-345472-qrddwebe	32	37	lactoferrin	lactoferrin	NNP
cord-345472-qrddwebe	32	38	)	)	-RRB-
cord-345472-qrddwebe	32	39	,	,	,
cord-345472-qrddwebe	32	40	and	and	CC
cord-345472-qrddwebe	32	41	tertiary	tertiary	JJ
cord-345472-qrddwebe	32	42	or	or	CC
cord-345472-qrddwebe	32	43	gelatinase	gelatinase	NN
cord-345472-qrddwebe	32	44	granules	granule	NNS
cord-345472-qrddwebe	32	45	(	(	-LRB-
cord-345472-qrddwebe	32	46	containing	contain	VBG
cord-345472-qrddwebe	32	47	,	,	,
cord-345472-qrddwebe	32	48	e.g.	e.g.	RB
cord-345472-qrddwebe	32	49	,	,	,
cord-345472-qrddwebe	32	50	cathelicidins	cathelicidin	NNS
cord-345472-qrddwebe	32	51	and	and	CC
cord-345472-qrddwebe	32	52	neutrophil	neutrophil	NN
cord-345472-qrddwebe	32	53	collagenase	collagenase	NNP
cord-345472-qrddwebe	32	54	)	)	-RRB-
cord-345472-qrddwebe	32	55	[	[	-LRB-
cord-345472-qrddwebe	32	56	16	16	CD
cord-345472-qrddwebe	32	57	]	]	-RRB-
cord-345472-qrddwebe	32	58	.	.	.
cord-345472-qrddwebe	33	1	This	this	DT
cord-345472-qrddwebe	33	2	classification	classification	NN
cord-345472-qrddwebe	33	3	is	be	VBZ
cord-345472-qrddwebe	33	4	based	base	VBN
cord-345472-qrddwebe	33	5	on	on	IN
cord-345472-qrddwebe	33	6	their	-PRON-	PRP$
cord-345472-qrddwebe	33	7	production	production	NN
cord-345472-qrddwebe	33	8	during	during	IN
cord-345472-qrddwebe	33	9	granulopoiesis	granulopoiesis	NN
cord-345472-qrddwebe	33	10	and	and	CC
cord-345472-qrddwebe	33	11	expression	expression	NN
cord-345472-qrddwebe	33	12	of	of	IN
cord-345472-qrddwebe	33	13	distinct	distinct	JJ
cord-345472-qrddwebe	33	14	protein	protein	NN
cord-345472-qrddwebe	33	15	markers	marker	NNS
cord-345472-qrddwebe	33	16	[	[	-LRB-
cord-345472-qrddwebe	33	17	16	16	CD
cord-345472-qrddwebe	33	18	]	]	-RRB-
cord-345472-qrddwebe	33	19	.	.	.
cord-345472-qrddwebe	34	1	As	as	IN
cord-345472-qrddwebe	34	2	a	a	DT
cord-345472-qrddwebe	34	3	consequence	consequence	NN
cord-345472-qrddwebe	34	4	of	of	IN
cord-345472-qrddwebe	34	5	phagocytosis	phagocytosis	NN
cord-345472-qrddwebe	34	6	,	,	,
cord-345472-qrddwebe	34	7	the	the	DT
cord-345472-qrddwebe	34	8	internalised	internalise	VBN
cord-345472-qrddwebe	34	9	microbe	microbe	NN
cord-345472-qrddwebe	34	10	is	be	VBZ
cord-345472-qrddwebe	34	11	trapped	trap	VBN
cord-345472-qrddwebe	34	12	in	in	IN
cord-345472-qrddwebe	34	13	'	'	``
cord-345472-qrddwebe	34	14	bag	bag	NN
cord-345472-qrddwebe	34	15	-	-	HYPH
cord-345472-qrddwebe	34	16	like	like	JJ
cord-345472-qrddwebe	34	17	'	'	''
cord-345472-qrddwebe	34	18	structures	structure	NNS
cord-345472-qrddwebe	34	19	known	know	VBN
cord-345472-qrddwebe	34	20	as	as	IN
cord-345472-qrddwebe	34	21	phagosomes	phagosomes	NNP
cord-345472-qrddwebe	34	22	,	,	,
cord-345472-qrddwebe	34	23	which	which	WDT
cord-345472-qrddwebe	34	24	fuse	fuse	VBP
cord-345472-qrddwebe	34	25	with	with	IN
cord-345472-qrddwebe	34	26	neutrophil	neutrophil	NN
cord-345472-qrddwebe	34	27	granules	granule	NNS
cord-345472-qrddwebe	34	28	for	for	IN
cord-345472-qrddwebe	34	29	the	the	DT
cord-345472-qrddwebe	34	30	safe	safe	JJ
cord-345472-qrddwebe	34	31	destruction	destruction	NN
cord-345472-qrddwebe	34	32	of	of	IN
cord-345472-qrddwebe	34	33	microbes	microbe	NNS
cord-345472-qrddwebe	34	34	[	[	-LRB-
cord-345472-qrddwebe	34	35	14	14	CD
cord-345472-qrddwebe	34	36	]	]	-RRB-
cord-345472-qrddwebe	34	37	.	.	.
cord-345472-qrddwebe	35	1	Upon	upon	IN
cord-345472-qrddwebe	35	2	fusion	fusion	NN
cord-345472-qrddwebe	35	3	,	,	,
cord-345472-qrddwebe	35	4	antimicrobial	antimicrobial	JJ
cord-345472-qrddwebe	35	5	molecules	molecule	NNS
cord-345472-qrddwebe	35	6	(	(	-LRB-
cord-345472-qrddwebe	35	7	summarised	summarise	VBN
cord-345472-qrddwebe	35	8	in	in	IN
cord-345472-qrddwebe	35	9	Table	Table	NNP
cord-345472-qrddwebe	35	10	1	1	CD
cord-345472-qrddwebe	35	11	)	)	-RRB-
cord-345472-qrddwebe	35	12	are	be	VBP
cord-345472-qrddwebe	35	13	released	release	VBN
cord-345472-qrddwebe	35	14	into	into	IN
cord-345472-qrddwebe	35	15	the	the	DT
cord-345472-qrddwebe	35	16	phagosome	phagosome	NN
cord-345472-qrddwebe	35	17	,	,	,
cord-345472-qrddwebe	35	18	whereupon	whereupon	RB
cord-345472-qrddwebe	35	19	they	-PRON-	PRP
cord-345472-qrddwebe	35	20	kill	kill	VBP
cord-345472-qrddwebe	35	21	the	the	DT
cord-345472-qrddwebe	35	22	trapped	trap	VBN
cord-345472-qrddwebe	35	23	microbe	microbe	NN
cord-345472-qrddwebe	35	24	[	[	-LRB-
cord-345472-qrddwebe	35	25	16	16	CD
cord-345472-qrddwebe	35	26	,	,	,
cord-345472-qrddwebe	35	27	17	17	CD
cord-345472-qrddwebe	35	28	]	]	-RRB-
cord-345472-qrddwebe	35	29	.	.	.
cord-345472-qrddwebe	36	1	Table	table	NN
cord-345472-qrddwebe	36	2	1	1	CD
cord-345472-qrddwebe	36	3	.	.	.
cord-345472-qrddwebe	37	1	Neutrophil	Neutrophil	NNP
cord-345472-qrddwebe	37	2	granules	granule	NNS
cord-345472-qrddwebe	37	3	and	and	CC
cord-345472-qrddwebe	37	4	their	-PRON-	PRP$
cord-345472-qrddwebe	37	5	anti	anti	JJ
cord-345472-qrddwebe	37	6	-	-	JJ
cord-345472-qrddwebe	37	7	microbial	microbial	JJ
cord-345472-qrddwebe	37	8	properties	property	NNS
cord-345472-qrddwebe	37	9	.	.	.
cord-345472-qrddwebe	38	1	Neutrophils	neutrophil	NNS
cord-345472-qrddwebe	38	2	can	can	MD
cord-345472-qrddwebe	38	3	also	also	RB
cord-345472-qrddwebe	38	4	eliminate	eliminate	VB
cord-345472-qrddwebe	38	5	microbes	microbe	NNS
cord-345472-qrddwebe	38	6	by	by	IN
cord-345472-qrddwebe	38	7	releasing	release	VBG
cord-345472-qrddwebe	38	8	extracellular	extracellular	JJ
cord-345472-qrddwebe	38	9	DNA	dna	NN
cord-345472-qrddwebe	38	10	traps	trap	NNS
cord-345472-qrddwebe	38	11	composed	compose	VBN
cord-345472-qrddwebe	38	12	of	of	IN
cord-345472-qrddwebe	38	13	decondensed	decondense	VBN
cord-345472-qrddwebe	38	14	nuclear	nuclear	JJ
cord-345472-qrddwebe	38	15	chromatin	chromatin	NNP
cord-345472-qrddwebe	38	16	,	,	,
cord-345472-qrddwebe	38	17	histones	histone	NNS
cord-345472-qrddwebe	38	18	,	,	,
cord-345472-qrddwebe	38	19	and	and	CC
cord-345472-qrddwebe	38	20	protein	protein	NN
cord-345472-qrddwebe	38	21	granules	granule	NNS
cord-345472-qrddwebe	38	22	,	,	,
cord-345472-qrddwebe	38	23	in	in	IN
cord-345472-qrddwebe	38	24	a	a	DT
cord-345472-qrddwebe	38	25	process	process	NN
cord-345472-qrddwebe	38	26	termed	term	VBN
cord-345472-qrddwebe	39	1	NETosis	NETosis	NNP
cord-345472-qrddwebe	39	2	[	[	-LRB-
cord-345472-qrddwebe	39	3	28	28	CD
cord-345472-qrddwebe	39	4	,	,	,
cord-345472-qrddwebe	39	5	29	29	CD
cord-345472-qrddwebe	39	6	]	]	-RRB-
cord-345472-qrddwebe	39	7	.	.	.
cord-345472-qrddwebe	40	1	Classical	classical	JJ
cord-345472-qrddwebe	40	2	activation	activation	NN
cord-345472-qrddwebe	40	3	of	of	IN
cord-345472-qrddwebe	40	4	NETosis	NETosis	NNP
cord-345472-qrddwebe	40	5	depends	depend	VBZ
cord-345472-qrddwebe	40	6	on	on	IN
cord-345472-qrddwebe	40	7	NADPH	NADPH	NNP
cord-345472-qrddwebe	40	8	oxidase	oxidase	NN
cord-345472-qrddwebe	40	9	-	-	HYPH
cord-345472-qrddwebe	40	10	mediated	mediate	VBN
cord-345472-qrddwebe	40	11	production	production	NN
cord-345472-qrddwebe	40	12	of	of	IN
cord-345472-qrddwebe	40	13	ROS	ROS	NNP
cord-345472-qrddwebe	40	14	[	[	-LRB-
cord-345472-qrddwebe	40	15	30	30	CD
cord-345472-qrddwebe	40	16	]	]	-RRB-
cord-345472-qrddwebe	40	17	,	,	,
cord-345472-qrddwebe	40	18	which	which	WDT
cord-345472-qrddwebe	40	19	promotes	promote	VBZ
cord-345472-qrddwebe	40	20	chromatin	chromatin	NN
cord-345472-qrddwebe	40	21	decondensation	decondensation	NN
cord-345472-qrddwebe	40	22	via	via	IN
cord-345472-qrddwebe	40	23	histone	histone	NN
cord-345472-qrddwebe	40	24	deamination	deamination	NN
cord-345472-qrddwebe	40	25	or	or	CC
cord-345472-qrddwebe	40	26	citrullination	citrullination	NN
cord-345472-qrddwebe	40	27	.	.	.
cord-345472-qrddwebe	41	1	This	this	DT
cord-345472-qrddwebe	41	2	process	process	NN
cord-345472-qrddwebe	41	3	is	be	VBZ
cord-345472-qrddwebe	41	4	aided	aid	VBN
cord-345472-qrddwebe	41	5	by	by	IN
cord-345472-qrddwebe	41	6	the	the	DT
cord-345472-qrddwebe	41	7	downstream	downstream	JJ
cord-345472-qrddwebe	41	8	activation	activation	NN
cord-345472-qrddwebe	41	9	of	of	IN
cord-345472-qrddwebe	41	10	the	the	DT
cord-345472-qrddwebe	41	11	protein	protein	NN
cord-345472-qrddwebe	41	12	-	-	HYPH
cord-345472-qrddwebe	41	13	arginine	arginine	NN
cord-345472-qrddwebe	41	14	deiminase	deiminase	NN
cord-345472-qrddwebe	41	15	type	type	NN
cord-345472-qrddwebe	41	16	4	4	CD
cord-345472-qrddwebe	41	17	(	(	-LRB-
cord-345472-qrddwebe	41	18	PAD4	PAD4	NNP
cord-345472-qrddwebe	41	19	)	)	-RRB-
cord-345472-qrddwebe	41	20	,	,	,
cord-345472-qrddwebe	41	21	a	a	DT
cord-345472-qrddwebe	41	22	nuclear	nuclear	JJ
cord-345472-qrddwebe	41	23	enzyme	enzyme	NN
cord-345472-qrddwebe	41	24	that	that	WDT
cord-345472-qrddwebe	41	25	citrullinates	citrullinate	VBZ
cord-345472-qrddwebe	41	26	arginine	arginine	NN
cord-345472-qrddwebe	41	27	residues	residue	NNS
cord-345472-qrddwebe	41	28	,	,	,
cord-345472-qrddwebe	41	29	converting	convert	VBG
cord-345472-qrddwebe	41	30	amine	amine	NN
cord-345472-qrddwebe	41	31	groups	group	NNS
cord-345472-qrddwebe	41	32	to	to	IN
cord-345472-qrddwebe	41	33	ketones	ketone	NNS
cord-345472-qrddwebe	41	34	[	[	-LRB-
cord-345472-qrddwebe	41	35	31	31	CD
cord-345472-qrddwebe	41	36	]	]	-RRB-
cord-345472-qrddwebe	42	1	[	[	-LRB-
cord-345472-qrddwebe	42	2	32	32	CD
cord-345472-qrddwebe	42	3	]	]	-RRB-
cord-345472-qrddwebe	42	4	[	[	-LRB-
cord-345472-qrddwebe	42	5	33	33	CD
cord-345472-qrddwebe	42	6	]	]	-RRB-
cord-345472-qrddwebe	42	7	.	.	.
cord-345472-qrddwebe	43	1	ROS	ROS	NNP
cord-345472-qrddwebe	43	2	production	production	NN
cord-345472-qrddwebe	43	3	can	can	MD
cord-345472-qrddwebe	43	4	also	also	RB
cord-345472-qrddwebe	43	5	activate	activate	VB
cord-345472-qrddwebe	43	6	azurophilic	azurophilic	JJ
cord-345472-qrddwebe	43	7	granules	granule	NNS
cord-345472-qrddwebe	43	8	to	to	TO
cord-345472-qrddwebe	43	9	release	release	VB
cord-345472-qrddwebe	43	10	myeloperoxidase	myeloperoxidase	NNP
cord-345472-qrddwebe	43	11	(	(	-LRB-
cord-345472-qrddwebe	43	12	MPO	MPO	NNP
cord-345472-qrddwebe	43	13	)	)	-RRB-
cord-345472-qrddwebe	43	14	and	and	CC
cord-345472-qrddwebe	43	15	neutrophil	neutrophil	NN
cord-345472-qrddwebe	43	16	elastase	elastase	NN
cord-345472-qrddwebe	43	17	(	(	-LRB-
cord-345472-qrddwebe	43	18	NE	NE	NNP
cord-345472-qrddwebe	43	19	)	)	-RRB-
cord-345472-qrddwebe	43	20	.	.	.
cord-345472-qrddwebe	44	1	If	if	IN
cord-345472-qrddwebe	44	2	these	these	DT
cord-345472-qrddwebe	44	3	enzymes	enzyme	NNS
cord-345472-qrddwebe	44	4	translocate	translocate	VBP
cord-345472-qrddwebe	44	5	to	to	IN
cord-345472-qrddwebe	44	6	the	the	DT
cord-345472-qrddwebe	44	7	nucleus	nucleus	NN
cord-345472-qrddwebe	44	8	,	,	,
cord-345472-qrddwebe	44	9	they	-PRON-	PRP
cord-345472-qrddwebe	44	10	can	can	MD
cord-345472-qrddwebe	44	11	disrupt	disrupt	VB
cord-345472-qrddwebe	44	12	chromatin	chromatin	NN
cord-345472-qrddwebe	44	13	packaging	packaging	NN
cord-345472-qrddwebe	44	14	[	[	-LRB-
cord-345472-qrddwebe	44	15	15	15	CD
cord-345472-qrddwebe	44	16	,	,	,
cord-345472-qrddwebe	44	17	17	17	CD
cord-345472-qrddwebe	44	18	]	]	-RRB-
cord-345472-qrddwebe	44	19	,	,	,
cord-345472-qrddwebe	44	20	and	and	CC
cord-345472-qrddwebe	44	21	promote	promote	VB
cord-345472-qrddwebe	44	22	the	the	DT
cord-345472-qrddwebe	44	23	release	release	NN
cord-345472-qrddwebe	44	24	of	of	IN
cord-345472-qrddwebe	44	25	chromatin	chromatin	NN
cord-345472-qrddwebe	44	26	,	,	,
cord-345472-qrddwebe	44	27	which	which	WDT
cord-345472-qrddwebe	44	28	then	then	RB
cord-345472-qrddwebe	44	29	interacts	interact	VBZ
cord-345472-qrddwebe	44	30	with	with	IN
cord-345472-qrddwebe	44	31	other	other	JJ
cord-345472-qrddwebe	44	32	granular	granular	JJ
cord-345472-qrddwebe	44	33	and	and	CC
cord-345472-qrddwebe	44	34	cytosolic	cytosolic	JJ
cord-345472-qrddwebe	44	35	proteins	protein	NNS
cord-345472-qrddwebe	44	36	to	to	TO
cord-345472-qrddwebe	44	37	form	form	VB
cord-345472-qrddwebe	44	38	'	'	``
cord-345472-qrddwebe	44	39	NETs	net	NNS
cord-345472-qrddwebe	44	40	'	'	''
cord-345472-qrddwebe	44	41	[	[	-LRB-
cord-345472-qrddwebe	44	42	30	30	CD
cord-345472-qrddwebe	44	43	]	]	-RRB-
cord-345472-qrddwebe	44	44	.	.	.
cord-345472-qrddwebe	45	1	These	these	DT
cord-345472-qrddwebe	45	2	NETs	net	NNS
cord-345472-qrddwebe	45	3	are	be	VBP
cord-345472-qrddwebe	45	4	important	important	JJ
cord-345472-qrddwebe	45	5	for	for	IN
cord-345472-qrddwebe	45	6	immunity	immunity	NN
cord-345472-qrddwebe	45	7	against	against	IN
cord-345472-qrddwebe	45	8	fungi	fungus	NNS
cord-345472-qrddwebe	45	9	and	and	CC
cord-345472-qrddwebe	45	10	some	some	DT
cord-345472-qrddwebe	45	11	bacterial	bacterial	JJ
cord-345472-qrddwebe	45	12	species	specie	NNS
cord-345472-qrddwebe	45	13	[	[	-LRB-
cord-345472-qrddwebe	45	14	22	22	CD
cord-345472-qrddwebe	45	15	,	,	,
cord-345472-qrddwebe	45	16	32	32	CD
cord-345472-qrddwebe	45	17	,	,	,
cord-345472-qrddwebe	45	18	34	34	CD
cord-345472-qrddwebe	45	19	]	]	-RRB-
cord-345472-qrddwebe	45	20	.	.	.
cord-345472-qrddwebe	46	1	For	for	IN
cord-345472-qrddwebe	46	2	example	example	NN
cord-345472-qrddwebe	46	3	,	,	,
cord-345472-qrddwebe	46	4	people	people	NNS
cord-345472-qrddwebe	46	5	who	who	WP
cord-345472-qrddwebe	46	6	are	be	VBP
cord-345472-qrddwebe	46	7	unable	unable	JJ
cord-345472-qrddwebe	46	8	to	to	TO
cord-345472-qrddwebe	46	9	produce	produce	VB
cord-345472-qrddwebe	46	10	NETs	net	NNS
cord-345472-qrddwebe	46	11	develop	develop	VB
cord-345472-qrddwebe	46	12	chronic	chronic	JJ
cord-345472-qrddwebe	46	13	granulomatous	granulomatous	JJ
cord-345472-qrddwebe	46	14	disease	disease	NN
cord-345472-qrddwebe	46	15	and	and	CC
cord-345472-qrddwebe	46	16	are	be	VBP
cord-345472-qrddwebe	46	17	highly	highly	RB
cord-345472-qrddwebe	46	18	susceptible	susceptible	JJ
cord-345472-qrddwebe	46	19	to	to	IN
cord-345472-qrddwebe	46	20	invasive	invasive	JJ
cord-345472-qrddwebe	46	21	aspergillosis	aspergillosis	NN
cord-345472-qrddwebe	46	22	[	[	-LRB-
cord-345472-qrddwebe	46	23	23	23	CD
cord-345472-qrddwebe	46	24	,	,	,
cord-345472-qrddwebe	46	25	35	35	CD
cord-345472-qrddwebe	46	26	]	]	-RRB-
cord-345472-qrddwebe	46	27	.	.	.
cord-345472-qrddwebe	47	1	Similarly	similarly	RB
cord-345472-qrddwebe	47	2	,	,	,
cord-345472-qrddwebe	47	3	individuals	individual	NNS
cord-345472-qrddwebe	47	4	lacking	lack	VBG
cord-345472-qrddwebe	47	5	MPO	MPO	NNP
cord-345472-qrddwebe	47	6	are	be	VBP
cord-345472-qrddwebe	47	7	susceptible	susceptible	JJ
cord-345472-qrddwebe	47	8	to	to	IN
cord-345472-qrddwebe	47	9	recurrent	recurrent	JJ
cord-345472-qrddwebe	47	10	fungal	fungal	JJ
cord-345472-qrddwebe	47	11	infections	infection	NNS
cord-345472-qrddwebe	47	12	[	[	-LRB-
cord-345472-qrddwebe	47	13	23	23	CD
cord-345472-qrddwebe	47	14	]	]	-RRB-
cord-345472-qrddwebe	47	15	.	.	.
cord-345472-qrddwebe	48	1	In	in	IN
cord-345472-qrddwebe	48	2	PAD4-deficient	PAD4-deficient	NNP
cord-345472-qrddwebe	48	3	mice	mouse	NNS
cord-345472-qrddwebe	48	4	,	,	,
cord-345472-qrddwebe	48	5	neutrophil	neutrophil	NN
cord-345472-qrddwebe	48	6	killing	killing	NN
cord-345472-qrddwebe	48	7	of	of	IN
cord-345472-qrddwebe	48	8	Shigella	Shigella	NNP
cord-345472-qrddwebe	48	9	flexneri	flexneri	NN
cord-345472-qrddwebe	48	10	or	or	CC
cord-345472-qrddwebe	48	11	group	group	NN
cord-345472-qrddwebe	48	12	A	a	DT
cord-345472-qrddwebe	48	13	Streptococcus	streptococcus	NN
cord-345472-qrddwebe	48	14	is	be	VBZ
cord-345472-qrddwebe	48	15	diminished	diminish	VBN
cord-345472-qrddwebe	48	16	[	[	-LRB-
cord-345472-qrddwebe	48	17	36	36	CD
cord-345472-qrddwebe	48	18	]	]	-RRB-
cord-345472-qrddwebe	48	19	.	.	.
cord-345472-qrddwebe	49	1	Collectively	collectively	RB
cord-345472-qrddwebe	49	2	,	,	,
cord-345472-qrddwebe	49	3	these	these	DT
cord-345472-qrddwebe	49	4	studies	study	NNS
cord-345472-qrddwebe	49	5	demonstrate	demonstrate	VBP
cord-345472-qrddwebe	49	6	that	that	IN
cord-345472-qrddwebe	49	7	NETosis	NETosis	NNP
cord-345472-qrddwebe	49	8	is	be	VBZ
cord-345472-qrddwebe	49	9	an	an	DT
cord-345472-qrddwebe	49	10	important	important	JJ
cord-345472-qrddwebe	49	11	weapon	weapon	NN
cord-345472-qrddwebe	49	12	in	in	IN
cord-345472-qrddwebe	49	13	the	the	DT
cord-345472-qrddwebe	49	14	host	host	NN
cord-345472-qrddwebe	49	15	's	's	POS
cord-345472-qrddwebe	49	16	defensive	defensive	JJ
cord-345472-qrddwebe	49	17	armoury	armoury	NN
cord-345472-qrddwebe	49	18	.	.	.
cord-345472-qrddwebe	50	1	However	however	RB
cord-345472-qrddwebe	50	2	,	,	,
cord-345472-qrddwebe	50	3	if	if	IN
cord-345472-qrddwebe	50	4	left	leave	VBN
cord-345472-qrddwebe	50	5	unchecked	unchecked	JJ
cord-345472-qrddwebe	50	6	,	,	,
cord-345472-qrddwebe	50	7	NET	net	NN
cord-345472-qrddwebe	50	8	-	-	HYPH
cord-345472-qrddwebe	50	9	induced	induce	VBN
cord-345472-qrddwebe	50	10	responses	response	NNS
cord-345472-qrddwebe	50	11	may	may	MD
cord-345472-qrddwebe	50	12	also	also	RB
cord-345472-qrddwebe	50	13	mediate	mediate	VB
cord-345472-qrddwebe	50	14	severe	severe	JJ
cord-345472-qrddwebe	50	15	pathology	pathology	NN
cord-345472-qrddwebe	50	16	.	.	.
cord-345472-qrddwebe	51	1	Excessive	excessive	JJ
cord-345472-qrddwebe	51	2	NETosis	netosis	NN
cord-345472-qrddwebe	51	3	can	can	MD
cord-345472-qrddwebe	51	4	damage	damage	VB
cord-345472-qrddwebe	51	5	the	the	DT
cord-345472-qrddwebe	51	6	epithelium	epithelium	NN
cord-345472-qrddwebe	51	7	in	in	IN
cord-345472-qrddwebe	51	8	pulmonary	pulmonary	JJ
cord-345472-qrddwebe	51	9	aspergillosis	aspergillosis	NN
cord-345472-qrddwebe	51	10	[	[	-LRB-
cord-345472-qrddwebe	51	11	37	37	CD
cord-345472-qrddwebe	51	12	]	]	-RRB-
cord-345472-qrddwebe	51	13	,	,	,
cord-345472-qrddwebe	51	14	damage	damage	VB
cord-345472-qrddwebe	51	15	the	the	DT
cord-345472-qrddwebe	51	16	endothelium	endothelium	NN
cord-345472-qrddwebe	51	17	in	in	IN
cord-345472-qrddwebe	51	18	transfusion	transfusion	NN
cord-345472-qrddwebe	51	19	-	-	HYPH
cord-345472-qrddwebe	51	20	related	relate	VBN
cord-345472-qrddwebe	51	21	acute	acute	JJ
cord-345472-qrddwebe	51	22	lung	lung	NN
cord-345472-qrddwebe	51	23	diseases	disease	NNS
cord-345472-qrddwebe	51	24	[	[	-LRB-
cord-345472-qrddwebe	51	25	38	38	CD
cord-345472-qrddwebe	51	26	]	]	-RRB-
cord-345472-qrddwebe	51	27	,	,	,
cord-345472-qrddwebe	51	28	and	and	CC
cord-345472-qrddwebe	51	29	exacerbate	exacerbate	VB
cord-345472-qrddwebe	51	30	rhinovirus	rhinovirus	NN
cord-345472-qrddwebe	51	31	infection	infection	NN
cord-345472-qrddwebe	51	32	-	-	HYPH
cord-345472-qrddwebe	51	33	induced	induce	VBN
cord-345472-qrddwebe	51	34	allergic	allergic	JJ
cord-345472-qrddwebe	51	35	asthma	asthma	NN
cord-345472-qrddwebe	51	36	[	[	-LRB-
cord-345472-qrddwebe	51	37	39	39	CD
cord-345472-qrddwebe	51	38	]	]	-RRB-
cord-345472-qrddwebe	51	39	.	.	.
cord-345472-qrddwebe	52	1	Therapeutic	therapeutic	JJ
cord-345472-qrddwebe	52	2	approaches	approach	NNS
cord-345472-qrddwebe	52	3	to	to	TO
cord-345472-qrddwebe	52	4	block	block	VB
cord-345472-qrddwebe	52	5	NETosis	NETosis	NNP
cord-345472-qrddwebe	52	6	are	be	VBP
cord-345472-qrddwebe	52	7	now	now	RB
cord-345472-qrddwebe	52	8	being	be	VBG
cord-345472-qrddwebe	52	9	assessed	assess	VBN
cord-345472-qrddwebe	52	10	for	for	IN
cord-345472-qrddwebe	52	11	the	the	DT
cord-345472-qrddwebe	52	12	treatment	treatment	NN
cord-345472-qrddwebe	52	13	of	of	IN
cord-345472-qrddwebe	52	14	infectious	infectious	JJ
cord-345472-qrddwebe	52	15	diseases	disease	NNS
cord-345472-qrddwebe	52	16	(	(	-LRB-
cord-345472-qrddwebe	52	17	including	include	VBG
cord-345472-qrddwebe	52	18	bacterial	bacterial	JJ
cord-345472-qrddwebe	52	19	sepsis	sepsis	NN
cord-345472-qrddwebe	52	20	)	)	-RRB-
cord-345472-qrddwebe	52	21	,	,	,
cord-345472-qrddwebe	52	22	autoimmune	autoimmune	JJ
cord-345472-qrddwebe	52	23	diseases	disease	NNS
cord-345472-qrddwebe	52	24	(	(	-LRB-
cord-345472-qrddwebe	52	25	including	include	VBG
cord-345472-qrddwebe	52	26	systemic	systemic	JJ
cord-345472-qrddwebe	52	27	lupus	lupus	NN
cord-345472-qrddwebe	52	28	erythematosus	erythematosus	NN
cord-345472-qrddwebe	52	29	[	[	-LRB-
cord-345472-qrddwebe	52	30	40	40	CD
cord-345472-qrddwebe	52	31	]	]	-RRB-
cord-345472-qrddwebe	52	32	,	,	,
cord-345472-qrddwebe	52	33	rheumatoid	rheumatoid	NN
cord-345472-qrddwebe	52	34	arthritis	arthritis	NN
cord-345472-qrddwebe	52	35	[	[	-LRB-
cord-345472-qrddwebe	52	36	41	41	CD
cord-345472-qrddwebe	52	37	]	]	-RRB-
cord-345472-qrddwebe	52	38	)	)	-RRB-
cord-345472-qrddwebe	52	39	and	and	CC
cord-345472-qrddwebe	52	40	chronic	chronic	JJ
cord-345472-qrddwebe	52	41	lung	lung	NN
cord-345472-qrddwebe	52	42	disorders	disorder	NNS
cord-345472-qrddwebe	52	43	(	(	-LRB-
cord-345472-qrddwebe	52	44	such	such	JJ
cord-345472-qrddwebe	52	45	as	as	IN
cord-345472-qrddwebe	52	46	cystic	cystic	JJ
cord-345472-qrddwebe	52	47	fibrosis	fibrosis	NN
cord-345472-qrddwebe	52	48	[	[	-LRB-
cord-345472-qrddwebe	52	49	42	42	CD
cord-345472-qrddwebe	52	50	]	]	-RRB-
cord-345472-qrddwebe	52	51	)	)	-RRB-
cord-345472-qrddwebe	52	52	.	.	.
cord-345472-qrddwebe	53	1	Neutrophils	neutrophil	NNS
cord-345472-qrddwebe	53	2	are	be	VBP
cord-345472-qrddwebe	53	3	a	a	DT
cord-345472-qrddwebe	53	4	vital	vital	JJ
cord-345472-qrddwebe	53	5	component	component	NN
cord-345472-qrddwebe	53	6	of	of	IN
cord-345472-qrddwebe	53	7	the	the	DT
cord-345472-qrddwebe	53	8	innate	innate	JJ
cord-345472-qrddwebe	53	9	immune	immune	JJ
cord-345472-qrddwebe	53	10	system	system	NN
cord-345472-qrddwebe	53	11	,	,	,
cord-345472-qrddwebe	53	12	with	with	IN
cord-345472-qrddwebe	53	13	key	key	JJ
cord-345472-qrddwebe	53	14	roles	role	NNS
cord-345472-qrddwebe	53	15	in	in	IN
cord-345472-qrddwebe	53	16	pathogen	pathogen	NN
cord-345472-qrddwebe	53	17	recognition	recognition	NN
cord-345472-qrddwebe	53	18	,	,	,
cord-345472-qrddwebe	53	19	the	the	DT
cord-345472-qrddwebe	53	20	killing	killing	NN
cord-345472-qrddwebe	53	21	of	of	IN
cord-345472-qrddwebe	53	22	invading	invade	VBG
cord-345472-qrddwebe	53	23	pathogens	pathogen	NNS
cord-345472-qrddwebe	53	24	,	,	,
cord-345472-qrddwebe	53	25	the	the	DT
cord-345472-qrddwebe	53	26	presentation	presentation	NN
cord-345472-qrddwebe	53	27	of	of	IN
cord-345472-qrddwebe	53	28	antigens	antigen	NNS
cord-345472-qrddwebe	53	29	to	to	IN
cord-345472-qrddwebe	53	30	T	T	NNP
cord-345472-qrddwebe	53	31	-	-	HYPH
cord-345472-qrddwebe	53	32	cells	cell	NNS
cord-345472-qrddwebe	53	33	,	,	,
cord-345472-qrddwebe	53	34	the	the	DT
cord-345472-qrddwebe	53	35	recruitment	recruitment	NN
cord-345472-qrddwebe	53	36	of	of	IN
cord-345472-qrddwebe	53	37	other	other	JJ
cord-345472-qrddwebe	53	38	inflammatory	inflammatory	JJ
cord-345472-qrddwebe	53	39	cells	cell	NNS
cord-345472-qrddwebe	53	40	,	,	,
cord-345472-qrddwebe	53	41	and	and	CC
cord-345472-qrddwebe	53	42	the	the	DT
cord-345472-qrddwebe	53	43	production	production	NN
cord-345472-qrddwebe	53	44	of	of	IN
cord-345472-qrddwebe	53	45	cytokines	cytokine	NNS
cord-345472-qrddwebe	53	46	[	[	-LRB-
cord-345472-qrddwebe	53	47	18	18	CD
cord-345472-qrddwebe	53	48	,	,	,
cord-345472-qrddwebe	53	49	43	43	CD
cord-345472-qrddwebe	53	50	]	]	-RRB-
cord-345472-qrddwebe	53	51	.	.	.
cord-345472-qrddwebe	54	1	For	for	IN
cord-345472-qrddwebe	54	2	sensing	sense	VBG
cord-345472-qrddwebe	54	3	invading	invade	VBG
cord-345472-qrddwebe	54	4	pathogens	pathogen	NNS
cord-345472-qrddwebe	54	5	,	,	,
cord-345472-qrddwebe	54	6	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	54	7	employ	employ	VBP
cord-345472-qrddwebe	54	8	a	a	DT
cord-345472-qrddwebe	54	9	vast	vast	JJ
cord-345472-qrddwebe	54	10	array	array	NN
cord-345472-qrddwebe	54	11	of	of	IN
cord-345472-qrddwebe	54	12	pattern	pattern	NN
cord-345472-qrddwebe	54	13	recognition	recognition	NN
cord-345472-qrddwebe	54	14	receptors	receptor	NNS
cord-345472-qrddwebe	54	15	(	(	-LRB-
cord-345472-qrddwebe	54	16	PRRs	PRRs	NNP
cord-345472-qrddwebe	54	17	)	)	-RRB-
cord-345472-qrddwebe	54	18	,	,	,
cord-345472-qrddwebe	54	19	including	include	VBG
cord-345472-qrddwebe	54	20	Toll	toll	NN
cord-345472-qrddwebe	54	21	-	-	HYPH
cord-345472-qrddwebe	54	22	like	like	JJ
cord-345472-qrddwebe	54	23	receptors	receptor	NNS
cord-345472-qrddwebe	54	24	(	(	-LRB-
cord-345472-qrddwebe	54	25	TLRs	TLRs	NNP
cord-345472-qrddwebe	54	26	)	)	-RRB-
cord-345472-qrddwebe	54	27	,	,	,
cord-345472-qrddwebe	54	28	C	c	NN
cord-345472-qrddwebe	54	29	-	-	HYPH
cord-345472-qrddwebe	54	30	type	type	NN
cord-345472-qrddwebe	54	31	lectin	lectin	NN
cord-345472-qrddwebe	54	32	receptors	receptor	NNS
cord-345472-qrddwebe	54	33	(	(	-LRB-
cord-345472-qrddwebe	54	34	e.g.	e.g.	RB
cord-345472-qrddwebe	54	35	,	,	,
cord-345472-qrddwebe	54	36	Dectin-1	Dectin-1	NNP
cord-345472-qrddwebe	54	37	)	)	-RRB-
cord-345472-qrddwebe	54	38	and	and	CC
cord-345472-qrddwebe	54	39	cytoplasmic	cytoplasmic	JJ
cord-345472-qrddwebe	54	40	sensors	sensor	NNS
cord-345472-qrddwebe	54	41	of	of	IN
cord-345472-qrddwebe	54	42	ribonucleic	ribonucleic	JJ
cord-345472-qrddwebe	54	43	acids	acid	NNS
cord-345472-qrddwebe	54	44	(	(	-LRB-
cord-345472-qrddwebe	54	45	RIG	rig	NN
cord-345472-qrddwebe	54	46	-	-	HYPH
cord-345472-qrddwebe	54	47	I	I	NNP
cord-345472-qrddwebe	54	48	and	and	CC
cord-345472-qrddwebe	54	49	MDA5	MDA5	NNP
cord-345472-qrddwebe	54	50	)	)	-RRB-
cord-345472-qrddwebe	54	51	[	[	-LRB-
cord-345472-qrddwebe	54	52	18	18	CD
cord-345472-qrddwebe	54	53	,	,	,
cord-345472-qrddwebe	54	54	44	44	CD
cord-345472-qrddwebe	54	55	,	,	,
cord-345472-qrddwebe	54	56	45	45	CD
cord-345472-qrddwebe	54	57	]	]	-RRB-
cord-345472-qrddwebe	54	58	.	.	.
cord-345472-qrddwebe	55	1	Neutrophils	Neutrophils	NNP
cord-345472-qrddwebe	55	2	also	also	RB
cord-345472-qrddwebe	55	3	express	express	VBP
cord-345472-qrddwebe	55	4	nucleotide	nucleotide	NN
cord-345472-qrddwebe	55	5	-	-	HYPH
cord-345472-qrddwebe	55	6	binding	bind	VBG
cord-345472-qrddwebe	55	7	oligomerisation	oligomerisation	NN
cord-345472-qrddwebe	55	8	domain	domain	NN
cord-345472-qrddwebe	55	9	(	(	-LRB-
cord-345472-qrddwebe	55	10	NOD)-like	nod)-like	CD
cord-345472-qrddwebe	55	11	receptors	receptor	NNS
cord-345472-qrddwebe	55	12	,	,	,
cord-345472-qrddwebe	55	13	important	important	JJ
cord-345472-qrddwebe	55	14	for	for	IN
cord-345472-qrddwebe	55	15	inflammasome	inflammasome	NN
cord-345472-qrddwebe	55	16	formation	formation	NN
cord-345472-qrddwebe	55	17	[	[	-LRB-
cord-345472-qrddwebe	55	18	46	46	CD
cord-345472-qrddwebe	55	19	]	]	-RRB-
cord-345472-qrddwebe	55	20	.	.	.
cord-345472-qrddwebe	56	1	The	the	DT
cord-345472-qrddwebe	56	2	sensing	sensing	NN
cord-345472-qrddwebe	56	3	of	of	IN
cord-345472-qrddwebe	56	4	pathogens	pathogen	NNS
cord-345472-qrddwebe	56	5	through	through	IN
cord-345472-qrddwebe	56	6	these	these	DT
cord-345472-qrddwebe	56	7	PRRs	prr	NNS
cord-345472-qrddwebe	56	8	activates	activate	VBZ
cord-345472-qrddwebe	56	9	the	the	DT
cord-345472-qrddwebe	56	10	effector	effector	NN
cord-345472-qrddwebe	56	11	functions	function	NNS
cord-345472-qrddwebe	56	12	of	of	IN
cord-345472-qrddwebe	56	13	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	56	14	,	,	,
cord-345472-qrddwebe	56	15	including	include	VBG
cord-345472-qrddwebe	56	16	ROS	ROS	NNP
cord-345472-qrddwebe	56	17	production	production	NN
cord-345472-qrddwebe	56	18	,	,	,
cord-345472-qrddwebe	56	19	NET	net	NN
cord-345472-qrddwebe	56	20	formation	formation	NN
cord-345472-qrddwebe	56	21	,	,	,
cord-345472-qrddwebe	56	22	and	and	CC
cord-345472-qrddwebe	56	23	degranulation	degranulation	NN
cord-345472-qrddwebe	56	24	(	(	-LRB-
cord-345472-qrddwebe	56	25	as	as	IN
cord-345472-qrddwebe	56	26	highlighted	highlight	VBN
cord-345472-qrddwebe	56	27	in	in	IN
cord-345472-qrddwebe	56	28	Section	section	NN
cord-345472-qrddwebe	56	29	2	2	CD
cord-345472-qrddwebe	56	30	)	)	-RRB-
cord-345472-qrddwebe	56	31	.	.	.
cord-345472-qrddwebe	57	1	Activated	activate	VBN
cord-345472-qrddwebe	57	2	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	57	3	may	may	MD
cord-345472-qrddwebe	57	4	also	also	RB
cord-345472-qrddwebe	57	5	influence	influence	VB
cord-345472-qrddwebe	57	6	the	the	DT
cord-345472-qrddwebe	57	7	quality	quality	NN
cord-345472-qrddwebe	57	8	of	of	IN
cord-345472-qrddwebe	57	9	innate	innate	JJ
cord-345472-qrddwebe	57	10	and	and	CC
cord-345472-qrddwebe	57	11	adaptive	adaptive	JJ
cord-345472-qrddwebe	57	12	immune	immune	JJ
cord-345472-qrddwebe	57	13	responses	response	NNS
cord-345472-qrddwebe	57	14	by	by	IN
cord-345472-qrddwebe	57	15	affecting	affect	VBG
cord-345472-qrddwebe	57	16	the	the	DT
cord-345472-qrddwebe	57	17	trafficking	trafficking	NN
cord-345472-qrddwebe	57	18	and	and	CC
cord-345472-qrddwebe	57	19	function	function	NN
cord-345472-qrddwebe	57	20	of	of	IN
cord-345472-qrddwebe	57	21	other	other	JJ
cord-345472-qrddwebe	57	22	innate	innate	JJ
cord-345472-qrddwebe	57	23	cells	cell	NNS
cord-345472-qrddwebe	57	24	,	,	,
cord-345472-qrddwebe	57	25	such	such	JJ
cord-345472-qrddwebe	57	26	as	as	IN
cord-345472-qrddwebe	57	27	dendritic	dendritic	JJ
cord-345472-qrddwebe	57	28	cells	cell	NNS
cord-345472-qrddwebe	57	29	(	(	-LRB-
cord-345472-qrddwebe	57	30	DCs	DCs	NNP
cord-345472-qrddwebe	57	31	)	)	-RRB-
cord-345472-qrddwebe	58	1	[	[	-LRB-
cord-345472-qrddwebe	58	2	47	47	CD
cord-345472-qrddwebe	58	3	]	]	-RRB-
cord-345472-qrddwebe	59	1	[	[	-LRB-
cord-345472-qrddwebe	59	2	48	48	CD
cord-345472-qrddwebe	59	3	]	]	-RRB-
cord-345472-qrddwebe	60	1	[	[	-LRB-
cord-345472-qrddwebe	60	2	49	49	CD
cord-345472-qrddwebe	60	3	]	]	-RRB-
cord-345472-qrddwebe	60	4	[	[	-LRB-
cord-345472-qrddwebe	60	5	50	50	CD
cord-345472-qrddwebe	60	6	]	]	-RRB-
cord-345472-qrddwebe	60	7	[	[	-LRB-
cord-345472-qrddwebe	60	8	51	51	CD
cord-345472-qrddwebe	60	9	]	]	-RRB-
cord-345472-qrddwebe	61	1	[	[	-LRB-
cord-345472-qrddwebe	61	2	52	52	CD
cord-345472-qrddwebe	61	3	]	]	-RRB-
cord-345472-qrddwebe	61	4	[	[	-LRB-
cord-345472-qrddwebe	61	5	53	53	CD
cord-345472-qrddwebe	61	6	]	]	-RRB-
cord-345472-qrddwebe	61	7	.	.	.
cord-345472-qrddwebe	62	1	For	for	IN
cord-345472-qrddwebe	62	2	example	example	NN
cord-345472-qrddwebe	62	3	,	,	,
cord-345472-qrddwebe	62	4	the	the	DT
cord-345472-qrddwebe	62	5	neutrophil	neutrophil	NN
cord-345472-qrddwebe	62	6	-	-	HYPH
cord-345472-qrddwebe	62	7	derived	derive	VBN
cord-345472-qrddwebe	62	8	chemokine	chemokine	NN
cord-345472-qrddwebe	62	9	CCL3	CCL3	NNP
cord-345472-qrddwebe	62	10	supports	support	VBZ
cord-345472-qrddwebe	62	11	the	the	DT
cord-345472-qrddwebe	62	12	rapid	rapid	JJ
cord-345472-qrddwebe	62	13	recruitment	recruitment	NN
cord-345472-qrddwebe	62	14	of	of	IN
cord-345472-qrddwebe	62	15	DCs	DCs	NNP
cord-345472-qrddwebe	62	16	to	to	IN
cord-345472-qrddwebe	62	17	the	the	DT
cord-345472-qrddwebe	62	18	inoculation	inoculation	NN
cord-345472-qrddwebe	62	19	site	site	NN
cord-345472-qrddwebe	62	20	during	during	IN
cord-345472-qrddwebe	62	21	Leishmania	Leishmania	NNP
cord-345472-qrddwebe	62	22	major	major	JJ
cord-345472-qrddwebe	62	23	infection	infection	NN
cord-345472-qrddwebe	62	24	[	[	-LRB-
cord-345472-qrddwebe	62	25	54	54	CD
cord-345472-qrddwebe	62	26	]	]	-RRB-
cord-345472-qrddwebe	62	27	.	.	.
cord-345472-qrddwebe	63	1	DC	DC	NNP
cord-345472-qrddwebe	63	2	function	function	NN
cord-345472-qrddwebe	63	3	can	can	MD
cord-345472-qrddwebe	63	4	also	also	RB
cord-345472-qrddwebe	63	5	be	be	VB
cord-345472-qrddwebe	63	6	affected	affect	VBN
cord-345472-qrddwebe	63	7	:	:	:
cord-345472-qrddwebe	63	8	in	in	IN
cord-345472-qrddwebe	63	9	the	the	DT
cord-345472-qrddwebe	63	10	context	context	NN
cord-345472-qrddwebe	63	11	of	of	IN
cord-345472-qrddwebe	63	12	an	an	DT
cord-345472-qrddwebe	63	13	infection	infection	NN
cord-345472-qrddwebe	63	14	with	with	IN
cord-345472-qrddwebe	63	15	Toxoplasma	toxoplasma	JJ
cord-345472-qrddwebe	63	16	gondii	gondii	NN
cord-345472-qrddwebe	63	17	,	,	,
cord-345472-qrddwebe	63	18	neutrophil	neutrophil	NN
cord-345472-qrddwebe	63	19	-	-	HYPH
cord-345472-qrddwebe	63	20	depletion	depletion	NN
cord-345472-qrddwebe	63	21	attenuated	attenuate	VBN
cord-345472-qrddwebe	63	22	interleukin	interleukin	NN
cord-345472-qrddwebe	63	23	(	(	-LRB-
cord-345472-qrddwebe	63	24	IL)-12	IL)-12	NNP
cord-345472-qrddwebe	63	25	and	and	CC
cord-345472-qrddwebe	63	26	TNF	tnf	NN
cord-345472-qrddwebe	63	27	production	production	NN
cord-345472-qrddwebe	63	28	by	by	IN
cord-345472-qrddwebe	63	29	splenic	splenic	JJ
cord-345472-qrddwebe	63	30	DCs	dc	NNS
cord-345472-qrddwebe	63	31	[	[	-LRB-
cord-345472-qrddwebe	63	32	55	55	CD
cord-345472-qrddwebe	63	33	]	]	-RRB-
cord-345472-qrddwebe	63	34	.	.	.
cord-345472-qrddwebe	64	1	Neutrophils	neutrophils	NN
cord-345472-qrddwebe	64	2	also	also	RB
cord-345472-qrddwebe	64	3	affect	affect	VBP
cord-345472-qrddwebe	64	4	the	the	DT
cord-345472-qrddwebe	64	5	recruitment	recruitment	NN
cord-345472-qrddwebe	64	6	of	of	IN
cord-345472-qrddwebe	64	7	other	other	JJ
cord-345472-qrddwebe	64	8	cells	cell	NNS
cord-345472-qrddwebe	64	9	too	too	RB
cord-345472-qrddwebe	64	10	,	,	,
cord-345472-qrddwebe	64	11	which	which	WDT
cord-345472-qrddwebe	64	12	they	-PRON-	PRP
cord-345472-qrddwebe	64	13	accomplish	accomplish	VBP
cord-345472-qrddwebe	64	14	via	via	IN
cord-345472-qrddwebe	64	15	the	the	DT
cord-345472-qrddwebe	64	16	secretion	secretion	NN
cord-345472-qrddwebe	64	17	of	of	IN
cord-345472-qrddwebe	64	18	pro	pro	JJ
cord-345472-qrddwebe	64	19	-	-	JJ
cord-345472-qrddwebe	64	20	inflammatory	inflammatory	JJ
cord-345472-qrddwebe	64	21	mediators	mediator	NNS
cord-345472-qrddwebe	64	22	such	such	JJ
cord-345472-qrddwebe	64	23	as	as	IN
cord-345472-qrddwebe	64	24	danger	danger	NN
cord-345472-qrddwebe	64	25	-	-	HYPH
cord-345472-qrddwebe	64	26	associated	associate	VBN
cord-345472-qrddwebe	64	27	molecular	molecular	JJ
cord-345472-qrddwebe	64	28	patterns	pattern	NNS
cord-345472-qrddwebe	64	29	(	(	-LRB-
cord-345472-qrddwebe	64	30	DAMPs	damp	NNS
cord-345472-qrddwebe	64	31	;	;	,
cord-345472-qrddwebe	64	32	e.g.	e.g.	RB
cord-345472-qrddwebe	64	33	,	,	,
cord-345472-qrddwebe	64	34	high	high	JJ
cord-345472-qrddwebe	64	35	mobility	mobility	NN
cord-345472-qrddwebe	64	36	group	group	NN
cord-345472-qrddwebe	64	37	box	box	NN
cord-345472-qrddwebe	64	38	1	1	CD
cord-345472-qrddwebe	64	39	(	(	-LRB-
cord-345472-qrddwebe	64	40	HMGB1	HMGB1	NNP
cord-345472-qrddwebe	64	41	)	)	-RRB-
cord-345472-qrddwebe	64	42	,	,	,
cord-345472-qrddwebe	64	43	double	double	JJ
cord-345472-qrddwebe	64	44	stranded	strand	VBN
cord-345472-qrddwebe	64	45	DNA	dna	NN
cord-345472-qrddwebe	64	46	,	,	,
cord-345472-qrddwebe	64	47	and	and	CC
cord-345472-qrddwebe	64	48	S100	S100	NNP
cord-345472-qrddwebe	64	49	complex	complex	JJ
cord-345472-qrddwebe	64	50	proteins	protein	NNS
cord-345472-qrddwebe	64	51	)	)	-RRB-
cord-345472-qrddwebe	64	52	,	,	,
cord-345472-qrddwebe	64	53	pro	pro	JJ
cord-345472-qrddwebe	64	54	-	-	JJ
cord-345472-qrddwebe	64	55	inflammatory	inflammatory	JJ
cord-345472-qrddwebe	64	56	cytokines	cytokine	NNS
cord-345472-qrddwebe	64	57	(	(	-LRB-
cord-345472-qrddwebe	64	58	e.g.	e.g.	RB
cord-345472-qrddwebe	64	59	,	,	,
cord-345472-qrddwebe	64	60	IL-1α	il-1α	NN
cord-345472-qrddwebe	64	61	,	,	,
cord-345472-qrddwebe	64	62	IL-1β	IL-1β	NNP
cord-345472-qrddwebe	64	63	,	,	,
cord-345472-qrddwebe	64	64	IL-6	IL-6	NNP
cord-345472-qrddwebe	64	65	,	,	,
cord-345472-qrddwebe	64	66	IL-17	IL-17	NNP
cord-345472-qrddwebe	64	67	,	,	,
cord-345472-qrddwebe	64	68	and	and	CC
cord-345472-qrddwebe	64	69	TNF	TNF	NNP
cord-345472-qrddwebe	64	70	)	)	-RRB-
cord-345472-qrddwebe	64	71	and	and	CC
cord-345472-qrddwebe	64	72	chemokines	chemokine	NNS
cord-345472-qrddwebe	64	73	(	(	-LRB-
cord-345472-qrddwebe	64	74	e.g.	e.g.	RB
cord-345472-qrddwebe	64	75	,	,	,
cord-345472-qrddwebe	64	76	CXCL1	CXCL1	NNP
cord-345472-qrddwebe	64	77	,	,	,
cord-345472-qrddwebe	64	78	CXCL2	cxcl2	NN
cord-345472-qrddwebe	64	79	,	,	,
cord-345472-qrddwebe	64	80	CXCL8	CXCL8	NNP
cord-345472-qrddwebe	64	81	,	,	,
cord-345472-qrddwebe	64	82	CCL2	CCL2	NNP
cord-345472-qrddwebe	64	83	,	,	,
cord-345472-qrddwebe	64	84	and	and	CC
cord-345472-qrddwebe	64	85	CCL3	CCL3	NNP
cord-345472-qrddwebe	64	86	)	)	-RRB-
cord-345472-qrddwebe	65	1	[	[	-LRB-
cord-345472-qrddwebe	65	2	12	12	CD
cord-345472-qrddwebe	65	3	,	,	,
cord-345472-qrddwebe	65	4	56	56	CD
cord-345472-qrddwebe	65	5	,	,	,
cord-345472-qrddwebe	65	6	57	57	CD
cord-345472-qrddwebe	65	7	]	]	-RRB-
cord-345472-qrddwebe	65	8	.	.	.
cord-345472-qrddwebe	66	1	Neutrophils	neutrophil	NNS
cord-345472-qrddwebe	66	2	can	can	MD
cord-345472-qrddwebe	66	3	also	also	RB
cord-345472-qrddwebe	66	4	initiate	initiate	VB
cord-345472-qrddwebe	66	5	adaptive	adaptive	JJ
cord-345472-qrddwebe	66	6	immune	immune	JJ
cord-345472-qrddwebe	66	7	responses	response	NNS
cord-345472-qrddwebe	66	8	by	by	IN
cord-345472-qrddwebe	66	9	directly	directly	RB
cord-345472-qrddwebe	66	10	presenting	present	VBG
cord-345472-qrddwebe	66	11	antigens	antigen	NNS
cord-345472-qrddwebe	66	12	themselves	-PRON-	PRP
cord-345472-qrddwebe	66	13	,	,	,
cord-345472-qrddwebe	66	14	or	or	CC
cord-345472-qrddwebe	66	15	by	by	IN
cord-345472-qrddwebe	66	16	acting	act	VBG
cord-345472-qrddwebe	66	17	as	as	IN
cord-345472-qrddwebe	66	18	accessory	accessory	NN
cord-345472-qrddwebe	66	19	cells	cell	NNS
cord-345472-qrddwebe	66	20	,	,	,
cord-345472-qrddwebe	66	21	to	to	TO
cord-345472-qrddwebe	66	22	support	support	VB
cord-345472-qrddwebe	66	23	T	t	NN
cord-345472-qrddwebe	66	24	-	-	HYPH
cord-345472-qrddwebe	66	25	cell	cell	NN
cord-345472-qrddwebe	66	26	responses	response	NNS
cord-345472-qrddwebe	66	27	.	.	.
cord-345472-qrddwebe	67	1	For	for	IN
cord-345472-qrddwebe	67	2	instance	instance	NN
cord-345472-qrddwebe	67	3	,	,	,
cord-345472-qrddwebe	67	4	human	human	JJ
cord-345472-qrddwebe	67	5	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	67	6	upregulate	upregulate	VBP
cord-345472-qrddwebe	67	7	MHC	MHC	NNP
cord-345472-qrddwebe	67	8	-	-	HYPH
cord-345472-qrddwebe	67	9	II	II	NNP
cord-345472-qrddwebe	67	10	and	and	CC
cord-345472-qrddwebe	67	11	co	co	JJ
cord-345472-qrddwebe	67	12	-	-	JJ
cord-345472-qrddwebe	67	13	stimulatory	stimulatory	JJ
cord-345472-qrddwebe	67	14	molecule	molecule	NN
cord-345472-qrddwebe	67	15	(	(	-LRB-
cord-345472-qrddwebe	67	16	CD40	CD40	NNP
cord-345472-qrddwebe	67	17	and	and	CC
cord-345472-qrddwebe	67	18	CD80	CD80	NNP
cord-345472-qrddwebe	67	19	)	)	-RRB-
cord-345472-qrddwebe	67	20	expression	expression	NN
cord-345472-qrddwebe	67	21	and	and	CC
cord-345472-qrddwebe	67	22	can	can	MD
cord-345472-qrddwebe	67	23	present	present	VB
cord-345472-qrddwebe	67	24	antigens	antigen	NNS
cord-345472-qrddwebe	67	25	to	to	IN
cord-345472-qrddwebe	67	26	CD4	CD4	NNP
cord-345472-qrddwebe	67	27	+	+	CC
cord-345472-qrddwebe	67	28	T	T	NNP
cord-345472-qrddwebe	67	29	-	-	HYPH
cord-345472-qrddwebe	67	30	cells	cell	NNS
cord-345472-qrddwebe	67	31	following	follow	VBG
cord-345472-qrddwebe	67	32	phagocytosis	phagocytosis	NN
cord-345472-qrddwebe	67	33	[	[	-LRB-
cord-345472-qrddwebe	67	34	58	58	CD
cord-345472-qrddwebe	67	35	]	]	-RRB-
cord-345472-qrddwebe	67	36	.	.	.
cord-345472-qrddwebe	68	1	Neutrophil	Neutrophil	NNP
cord-345472-qrddwebe	68	2	acquisition	acquisition	NN
cord-345472-qrddwebe	68	3	of	of	IN
cord-345472-qrddwebe	68	4	these	these	DT
cord-345472-qrddwebe	68	5	antigen	antigen	NN
cord-345472-qrddwebe	68	6	-	-	HYPH
cord-345472-qrddwebe	68	7	presenting	present	VBG
cord-345472-qrddwebe	68	8	properties	property	NNS
cord-345472-qrddwebe	68	9	(	(	-LRB-
cord-345472-qrddwebe	68	10	MHC	MHC	NNP
cord-345472-qrddwebe	68	11	-	-	HYPH
cord-345472-qrddwebe	68	12	II	II	NNP
cord-345472-qrddwebe	68	13	,	,	,
cord-345472-qrddwebe	68	14	CD40	CD40	NNP
cord-345472-qrddwebe	68	15	,	,	,
cord-345472-qrddwebe	68	16	and	and	CC
cord-345472-qrddwebe	68	17	CD80	CD80	NNP
cord-345472-qrddwebe	68	18	expression	expression	NN
cord-345472-qrddwebe	68	19	)	)	-RRB-
cord-345472-qrddwebe	68	20	is	be	VBZ
cord-345472-qrddwebe	68	21	associated	associate	VBN
cord-345472-qrddwebe	68	22	with	with	IN
cord-345472-qrddwebe	68	23	increased	increase	VBN
cord-345472-qrddwebe	68	24	activation	activation	NN
cord-345472-qrddwebe	68	25	and	and	CC
cord-345472-qrddwebe	68	26	proliferation	proliferation	NN
cord-345472-qrddwebe	68	27	of	of	IN
cord-345472-qrddwebe	68	28	CD4	CD4	NNP
cord-345472-qrddwebe	68	29	+	+	CC
cord-345472-qrddwebe	68	30	T	T	NNP
cord-345472-qrddwebe	68	31	-	-	HYPH
cord-345472-qrddwebe	68	32	cells	cell	NNS
cord-345472-qrddwebe	68	33	in	in	IN
cord-345472-qrddwebe	68	34	response	response	NN
cord-345472-qrddwebe	68	35	to	to	IN
cord-345472-qrddwebe	68	36	tetanus	tetanus	NN
cord-345472-qrddwebe	68	37	toxoid	toxoid	NN
cord-345472-qrddwebe	68	38	.	.	.
cord-345472-qrddwebe	69	1	Neutrophils	neutrophil	NNS
cord-345472-qrddwebe	69	2	can	can	MD
cord-345472-qrddwebe	69	3	also	also	RB
cord-345472-qrddwebe	69	4	direct	direct	VB
cord-345472-qrddwebe	69	5	T	t	NN
cord-345472-qrddwebe	69	6	-	-	HYPH
cord-345472-qrddwebe	69	7	cell	cell	NN
cord-345472-qrddwebe	69	8	recruitment	recruitment	NN
cord-345472-qrddwebe	69	9	to	to	IN
cord-345472-qrddwebe	69	10	the	the	DT
cord-345472-qrddwebe	69	11	site	site	NN
cord-345472-qrddwebe	69	12	of	of	IN
cord-345472-qrddwebe	69	13	infection	infection	NN
cord-345472-qrddwebe	69	14	.	.	.
cord-345472-qrddwebe	70	1	For	for	IN
cord-345472-qrddwebe	70	2	example	example	NN
cord-345472-qrddwebe	70	3	,	,	,
cord-345472-qrddwebe	70	4	in	in	IN
cord-345472-qrddwebe	70	5	response	response	NN
cord-345472-qrddwebe	70	6	to	to	IN
cord-345472-qrddwebe	70	7	influenza	influenza	NN
cord-345472-qrddwebe	70	8	virus	virus	NN
cord-345472-qrddwebe	70	9	infection	infection	NN
cord-345472-qrddwebe	70	10	,	,	,
cord-345472-qrddwebe	70	11	lung	lung	NN
cord-345472-qrddwebe	70	12	-	-	HYPH
cord-345472-qrddwebe	70	13	infiltrating	infiltrate	VBG
cord-345472-qrddwebe	70	14	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	70	15	were	be	VBD
cord-345472-qrddwebe	70	16	found	find	VBN
cord-345472-qrddwebe	70	17	to	to	TO
cord-345472-qrddwebe	70	18	deposit	deposit	VB
cord-345472-qrddwebe	70	19	a	a	DT
cord-345472-qrddwebe	70	20	long	long	RB
cord-345472-qrddwebe	70	21	-	-	HYPH
cord-345472-qrddwebe	70	22	lasting	last	VBG
cord-345472-qrddwebe	70	23	chemoattracting	chemoattracte	VBG
cord-345472-qrddwebe	70	24	trail	trail	NN
cord-345472-qrddwebe	70	25	(	(	-LRB-
cord-345472-qrddwebe	70	26	expressing	express	VBG
cord-345472-qrddwebe	70	27	the	the	DT
cord-345472-qrddwebe	70	28	chemokine	chemokine	NN
cord-345472-qrddwebe	70	29	CXCL12	CXCL12	VBG
cord-345472-qrddwebe	70	30	)	)	-RRB-
cord-345472-qrddwebe	70	31	in	in	IN
cord-345472-qrddwebe	70	32	the	the	DT
cord-345472-qrddwebe	70	33	lung	lung	NN
cord-345472-qrddwebe	70	34	to	to	TO
cord-345472-qrddwebe	70	35	guide	guide	VB
cord-345472-qrddwebe	70	36	antigen	antigen	NN
cord-345472-qrddwebe	70	37	-	-	HYPH
cord-345472-qrddwebe	70	38	specific	specific	JJ
cord-345472-qrddwebe	70	39	CD8	CD8	NNP
cord-345472-qrddwebe	70	40	+	+	CC
cord-345472-qrddwebe	70	41	T	T	NNP
cord-345472-qrddwebe	70	42	-	-	HYPH
cord-345472-qrddwebe	70	43	cells	cell	NNS
cord-345472-qrddwebe	70	44	into	into	IN
cord-345472-qrddwebe	70	45	specific	specific	JJ
cord-345472-qrddwebe	70	46	niches	niche	NNS
cord-345472-qrddwebe	70	47	[	[	-LRB-
cord-345472-qrddwebe	70	48	59	59	CD
cord-345472-qrddwebe	70	49	]	]	-RRB-
cord-345472-qrddwebe	70	50	.	.	.
cord-345472-qrddwebe	71	1	In	in	IN
cord-345472-qrddwebe	71	2	the	the	DT
cord-345472-qrddwebe	71	3	absence	absence	NN
cord-345472-qrddwebe	71	4	of	of	IN
cord-345472-qrddwebe	71	5	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	71	6	,	,	,
cord-345472-qrddwebe	71	7	influenza	influenza	NN
cord-345472-qrddwebe	71	8	-	-	HYPH
cord-345472-qrddwebe	71	9	specific	specific	JJ
cord-345472-qrddwebe	71	10	CD8	CD8	NNP
cord-345472-qrddwebe	71	11	+	+	CC
cord-345472-qrddwebe	71	12	T	T	NNP
cord-345472-qrddwebe	71	13	-	-	HYPH
cord-345472-qrddwebe	71	14	cells	cell	NNS
cord-345472-qrddwebe	71	15	were	be	VBD
cord-345472-qrddwebe	71	16	lower	low	JJR
cord-345472-qrddwebe	71	17	in	in	IN
cord-345472-qrddwebe	71	18	the	the	DT
cord-345472-qrddwebe	71	19	lung	lung	NN
cord-345472-qrddwebe	71	20	,	,	,
cord-345472-qrddwebe	71	21	leading	lead	VBG
cord-345472-qrddwebe	71	22	to	to	IN
cord-345472-qrddwebe	71	23	increased	increase	VBN
cord-345472-qrddwebe	71	24	viral	viral	JJ
cord-345472-qrddwebe	71	25	load	load	NN
cord-345472-qrddwebe	71	26	and	and	CC
cord-345472-qrddwebe	71	27	delayed	delay	VBN
cord-345472-qrddwebe	71	28	viral	viral	JJ
cord-345472-qrddwebe	71	29	clearance	clearance	NN
cord-345472-qrddwebe	71	30	.	.	.
cord-345472-qrddwebe	72	1	Neutrophils	neutrophil	NNS
cord-345472-qrddwebe	72	2	can	can	MD
cord-345472-qrddwebe	72	3	also	also	RB
cord-345472-qrddwebe	72	4	influence	influence	VB
cord-345472-qrddwebe	72	5	CD4	CD4	NNP
cord-345472-qrddwebe	72	6	+	+	CC
cord-345472-qrddwebe	72	7	T	t	NN
cord-345472-qrddwebe	72	8	cell	cell	NN
cord-345472-qrddwebe	72	9	helper	helper	NN
cord-345472-qrddwebe	72	10	(	(	-LRB-
cord-345472-qrddwebe	72	11	Th	Th	NNP
cord-345472-qrddwebe	72	12	)	)	-RRB-
cord-345472-qrddwebe	72	13	responses	response	NNS
cord-345472-qrddwebe	72	14	,	,	,
cord-345472-qrddwebe	72	15	in	in	IN
cord-345472-qrddwebe	72	16	particular	particular	JJ
cord-345472-qrddwebe	72	17	,	,	,
cord-345472-qrddwebe	72	18	Th17	Th17	NNP
cord-345472-qrddwebe	73	1	immune	immune	JJ
cord-345472-qrddwebe	73	2	responses	response	NNS
cord-345472-qrddwebe	73	3	[	[	-LRB-
cord-345472-qrddwebe	73	4	50	50	CD
cord-345472-qrddwebe	73	5	,	,	,
cord-345472-qrddwebe	73	6	51	51	CD
cord-345472-qrddwebe	73	7	,	,	,
cord-345472-qrddwebe	73	8	60	60	CD
cord-345472-qrddwebe	73	9	]	]	-RRB-
cord-345472-qrddwebe	73	10	.	.	.
cord-345472-qrddwebe	74	1	In	in	IN
cord-345472-qrddwebe	74	2	a	a	DT
cord-345472-qrddwebe	74	3	mouse	mouse	NN
cord-345472-qrddwebe	74	4	model	model	NN
cord-345472-qrddwebe	74	5	of	of	IN
cord-345472-qrddwebe	74	6	allergic	allergic	JJ
cord-345472-qrddwebe	74	7	asthma	asthma	NN
cord-345472-qrddwebe	74	8	,	,	,
cord-345472-qrddwebe	74	9	neutrophil	neutrophil	NN
cord-345472-qrddwebe	74	10	cytoplasts	cytoplast	NNS
cord-345472-qrddwebe	74	11	(	(	-LRB-
cord-345472-qrddwebe	74	12	enucleated	enucleated	JJ
cord-345472-qrddwebe	74	13	cell	cell	NN
cord-345472-qrddwebe	74	14	bodies	body	NNS
cord-345472-qrddwebe	74	15	)	)	-RRB-
cord-345472-qrddwebe	74	16	augmented	augment	VBN
cord-345472-qrddwebe	74	17	DC	DC	NNP
cord-345472-qrddwebe	74	18	-	-	HYPH
cord-345472-qrddwebe	74	19	mediated	mediate	VBN
cord-345472-qrddwebe	74	20	Th17	Th17	NNP
cord-345472-qrddwebe	75	1	responses	response	NNS
cord-345472-qrddwebe	75	2	in	in	IN
cord-345472-qrddwebe	75	3	the	the	DT
cord-345472-qrddwebe	75	4	lymph	lymph	NN
cord-345472-qrddwebe	75	5	nodes	node	NNS
cord-345472-qrddwebe	75	6	,	,	,
cord-345472-qrddwebe	75	7	which	which	WDT
cord-345472-qrddwebe	75	8	subsequently	subsequently	RB
cord-345472-qrddwebe	75	9	increased	increase	VBD
cord-345472-qrddwebe	75	10	asthma	asthma	NN
cord-345472-qrddwebe	75	11	-	-	HYPH
cord-345472-qrddwebe	75	12	like	like	JJ
cord-345472-qrddwebe	75	13	pathology	pathology	NN
cord-345472-qrddwebe	75	14	in	in	IN
cord-345472-qrddwebe	75	15	the	the	DT
cord-345472-qrddwebe	75	16	lung	lung	NN
cord-345472-qrddwebe	75	17	[	[	-LRB-
cord-345472-qrddwebe	75	18	51	51	CD
cord-345472-qrddwebe	75	19	]	]	-RRB-
cord-345472-qrddwebe	75	20	.	.	.
cord-345472-qrddwebe	76	1	Collectively	collectively	RB
cord-345472-qrddwebe	76	2	,	,	,
cord-345472-qrddwebe	76	3	these	these	DT
cord-345472-qrddwebe	76	4	studies	study	NNS
cord-345472-qrddwebe	76	5	demonstrate	demonstrate	VBP
cord-345472-qrddwebe	76	6	that	that	IN
cord-345472-qrddwebe	76	7	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	76	8	are	be	VBP
cord-345472-qrddwebe	76	9	important	important	JJ
cord-345472-qrddwebe	76	10	participants	participant	NNS
cord-345472-qrddwebe	76	11	in	in	IN
cord-345472-qrddwebe	76	12	innate	innate	JJ
cord-345472-qrddwebe	76	13	immunity	immunity	NN
cord-345472-qrddwebe	76	14	and	and	CC
cord-345472-qrddwebe	76	15	contribute	contribute	VB
cord-345472-qrddwebe	76	16	to	to	IN
cord-345472-qrddwebe	76	17	effective	effective	JJ
cord-345472-qrddwebe	76	18	adaptive	adaptive	JJ
cord-345472-qrddwebe	76	19	immune	immune	JJ
cord-345472-qrddwebe	76	20	responses	response	NNS
cord-345472-qrddwebe	76	21	.	.	.
cord-345472-qrddwebe	77	1	The	the	DT
cord-345472-qrddwebe	77	2	vast	vast	JJ
cord-345472-qrddwebe	77	3	majority	majority	NN
cord-345472-qrddwebe	77	4	of	of	IN
cord-345472-qrddwebe	77	5	human	human	JJ
cord-345472-qrddwebe	77	6	respiratory	respiratory	JJ
cord-345472-qrddwebe	77	7	viruses	virus	NNS
cord-345472-qrddwebe	77	8	,	,	,
cord-345472-qrddwebe	77	9	including	include	VBG
cord-345472-qrddwebe	77	10	RSV	RSV	NNP
cord-345472-qrddwebe	77	11	,	,	,
cord-345472-qrddwebe	77	12	rhinovirus	rhinovirus	NN
cord-345472-qrddwebe	77	13	,	,	,
cord-345472-qrddwebe	77	14	influenza	influenza	NN
cord-345472-qrddwebe	77	15	,	,	,
cord-345472-qrddwebe	77	16	coronavirus	coronavirus	NN
cord-345472-qrddwebe	77	17	,	,	,
cord-345472-qrddwebe	77	18	adenovirus	adenovirus	NN
cord-345472-qrddwebe	77	19	,	,	,
cord-345472-qrddwebe	77	20	and	and	CC
cord-345472-qrddwebe	77	21	parainfluenza	parainfluenza	NNP
cord-345472-qrddwebe	77	22	virus	virus	NNP
cord-345472-qrddwebe	77	23	,	,	,
cord-345472-qrddwebe	77	24	can	can	MD
cord-345472-qrddwebe	77	25	cause	cause	VB
cord-345472-qrddwebe	77	26	bronchiolitis	bronchiolitis	NNP
cord-345472-qrddwebe	77	27	[	[	-LRB-
cord-345472-qrddwebe	77	28	61	61	CD
cord-345472-qrddwebe	77	29	]	]	-RRB-
cord-345472-qrddwebe	77	30	.	.	.
cord-345472-qrddwebe	78	1	However	however	RB
cord-345472-qrddwebe	78	2	,	,	,
cord-345472-qrddwebe	78	3	RSV	RSV	NNP
cord-345472-qrddwebe	78	4	-	-	HYPH
cord-345472-qrddwebe	78	5	induced	induce	VBN
cord-345472-qrddwebe	78	6	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	78	7	is	be	VBZ
cord-345472-qrddwebe	78	8	the	the	DT
cord-345472-qrddwebe	78	9	leading	leading	JJ
cord-345472-qrddwebe	78	10	cause	cause	NN
cord-345472-qrddwebe	78	11	of	of	IN
cord-345472-qrddwebe	78	12	hospitalisation	hospitalisation	NN
cord-345472-qrddwebe	78	13	and	and	CC
cord-345472-qrddwebe	78	14	death	death	NN
cord-345472-qrddwebe	78	15	among	among	IN
cord-345472-qrddwebe	78	16	infants	infant	NNS
cord-345472-qrddwebe	78	17	within	within	IN
cord-345472-qrddwebe	78	18	the	the	DT
cord-345472-qrddwebe	78	19	first	first	JJ
cord-345472-qrddwebe	78	20	two	two	CD
cord-345472-qrddwebe	78	21	years	year	NNS
cord-345472-qrddwebe	78	22	of	of	IN
cord-345472-qrddwebe	78	23	life	life	NN
cord-345472-qrddwebe	78	24	[	[	-LRB-
cord-345472-qrddwebe	78	25	1	1	CD
cord-345472-qrddwebe	78	26	,	,	,
cord-345472-qrddwebe	78	27	62	62	CD
cord-345472-qrddwebe	78	28	]	]	-RRB-
cord-345472-qrddwebe	78	29	.	.	.
cord-345472-qrddwebe	79	1	RSV	RSV	NNP
cord-345472-qrddwebe	79	2	is	be	VBZ
cord-345472-qrddwebe	79	3	highly	highly	RB
cord-345472-qrddwebe	79	4	contagious	contagious	JJ
cord-345472-qrddwebe	79	5	and	and	CC
cord-345472-qrddwebe	79	6	persists	persist	VBZ
cord-345472-qrddwebe	79	7	outside	outside	IN
cord-345472-qrddwebe	79	8	of	of	IN
cord-345472-qrddwebe	79	9	the	the	DT
cord-345472-qrddwebe	79	10	host	host	NN
cord-345472-qrddwebe	79	11	for	for	IN
cord-345472-qrddwebe	79	12	almost	almost	RB
cord-345472-qrddwebe	79	13	six	six	CD
cord-345472-qrddwebe	79	14	hours	hour	NNS
cord-345472-qrddwebe	79	15	[	[	-LRB-
cord-345472-qrddwebe	79	16	63	63	CD
cord-345472-qrddwebe	79	17	]	]	-RRB-
cord-345472-qrddwebe	79	18	.	.	.
cord-345472-qrddwebe	80	1	This	this	DT
cord-345472-qrddwebe	80	2	prolonged	prolong	VBN
cord-345472-qrddwebe	80	3	survival	survival	NN
cord-345472-qrddwebe	80	4	facilitates	facilitate	VBZ
cord-345472-qrddwebe	80	5	its	-PRON-	PRP$
cord-345472-qrddwebe	80	6	spread	spread	NN
cord-345472-qrddwebe	80	7	to	to	IN
cord-345472-qrddwebe	80	8	susceptible	susceptible	JJ
cord-345472-qrddwebe	80	9	individuals	individual	NNS
cord-345472-qrddwebe	80	10	,	,	,
cord-345472-qrddwebe	80	11	mainly	mainly	RB
cord-345472-qrddwebe	80	12	via	via	IN
cord-345472-qrddwebe	80	13	inoculation	inoculation	NN
cord-345472-qrddwebe	80	14	of	of	IN
cord-345472-qrddwebe	80	15	open	open	JJ
cord-345472-qrddwebe	80	16	mucous	mucous	JJ
cord-345472-qrddwebe	80	17	membranes	membrane	NNS
cord-345472-qrddwebe	80	18	lining	line	VBG
cord-345472-qrddwebe	80	19	the	the	DT
cord-345472-qrddwebe	80	20	eyes	eye	NNS
cord-345472-qrddwebe	80	21	and	and	CC
cord-345472-qrddwebe	80	22	buccal	buccal	JJ
cord-345472-qrddwebe	80	23	cavity	cavity	NN
cord-345472-qrddwebe	80	24	.	.	.
cord-345472-qrddwebe	81	1	Upon	upon	IN
cord-345472-qrddwebe	81	2	inoculation	inoculation	NN
cord-345472-qrddwebe	81	3	,	,	,
cord-345472-qrddwebe	81	4	RSV	RSV	NNP
cord-345472-qrddwebe	81	5	infects	infect	VBZ
cord-345472-qrddwebe	81	6	the	the	DT
cord-345472-qrddwebe	81	7	nasopharyngeal	nasopharyngeal	JJ
cord-345472-qrddwebe	81	8	epithelium	epithelium	NN
cord-345472-qrddwebe	81	9	of	of	IN
cord-345472-qrddwebe	81	10	the	the	DT
cord-345472-qrddwebe	81	11	upper	upper	JJ
cord-345472-qrddwebe	81	12	respiratory	respiratory	JJ
cord-345472-qrddwebe	81	13	tract	tract	NN
cord-345472-qrddwebe	81	14	,	,	,
cord-345472-qrddwebe	81	15	replicates	replicate	VBZ
cord-345472-qrddwebe	81	16	in	in	IN
cord-345472-qrddwebe	81	17	epithelial	epithelial	JJ
cord-345472-qrddwebe	81	18	cells	cell	NNS
cord-345472-qrddwebe	81	19	,	,	,
cord-345472-qrddwebe	81	20	and	and	CC
cord-345472-qrddwebe	81	21	then	then	RB
cord-345472-qrddwebe	81	22	spreads	spread	VBZ
cord-345472-qrddwebe	81	23	to	to	IN
cord-345472-qrddwebe	81	24	the	the	DT
cord-345472-qrddwebe	81	25	LRT	LRT	NNP
cord-345472-qrddwebe	81	26	via	via	IN
cord-345472-qrddwebe	81	27	the	the	DT
cord-345472-qrddwebe	81	28	bronchiolar	bronchiolar	JJ
cord-345472-qrddwebe	81	29	epithelium	epithelium	NN
cord-345472-qrddwebe	81	30	[	[	-LRB-
cord-345472-qrddwebe	81	31	9	9	CD
cord-345472-qrddwebe	81	32	,	,	,
cord-345472-qrddwebe	81	33	64	64	CD
cord-345472-qrddwebe	81	34	]	]	-RRB-
cord-345472-qrddwebe	81	35	.	.	.
cord-345472-qrddwebe	82	1	This	this	DT
cord-345472-qrddwebe	82	2	occurs	occur	VBZ
cord-345472-qrddwebe	82	3	within	within	IN
cord-345472-qrddwebe	82	4	1	1	CD
cord-345472-qrddwebe	82	5	-	-	SYM
cord-345472-qrddwebe	82	6	3	3	CD
cord-345472-qrddwebe	82	7	days	day	NNS
cord-345472-qrddwebe	82	8	post	post	NN
cord-345472-qrddwebe	82	9	infection	infection	NN
cord-345472-qrddwebe	82	10	,	,	,
cord-345472-qrddwebe	82	11	with	with	IN
cord-345472-qrddwebe	82	12	peak	peak	NN
cord-345472-qrddwebe	82	13	infectivity	infectivity	NN
cord-345472-qrddwebe	82	14	occurring	occur	VBG
cord-345472-qrddwebe	82	15	at	at	IN
cord-345472-qrddwebe	82	16	5	5	CD
cord-345472-qrddwebe	82	17	-	-	SYM
cord-345472-qrddwebe	82	18	7	7	CD
cord-345472-qrddwebe	82	19	days	day	NNS
cord-345472-qrddwebe	82	20	post	post	NN
cord-345472-qrddwebe	82	21	-	-	NN
cord-345472-qrddwebe	82	22	inoculation	inoculation	NN
cord-345472-qrddwebe	82	23	[	[	-LRB-
cord-345472-qrddwebe	82	24	3	3	CD
cord-345472-qrddwebe	82	25	,	,	,
cord-345472-qrddwebe	82	26	65	65	CD
cord-345472-qrddwebe	82	27	]	]	-RRB-
cord-345472-qrddwebe	82	28	.	.	.
cord-345472-qrddwebe	83	1	During	during	IN
cord-345472-qrddwebe	83	2	this	this	DT
cord-345472-qrddwebe	83	3	period	period	NN
cord-345472-qrddwebe	83	4	,	,	,
cord-345472-qrddwebe	83	5	RSV	RSV	NNP
cord-345472-qrddwebe	83	6	triggers	trigger	VBZ
cord-345472-qrddwebe	83	7	extensive	extensive	JJ
cord-345472-qrddwebe	83	8	inflammation	inflammation	NN
cord-345472-qrddwebe	83	9	(	(	-LRB-
cord-345472-qrddwebe	83	10	characterised	characterise	VBN
cord-345472-qrddwebe	83	11	by	by	IN
cord-345472-qrddwebe	83	12	increased	increase	VBN
cord-345472-qrddwebe	83	13	neutrophilia	neutrophilia	NNS
cord-345472-qrddwebe	83	14	and	and	CC
cord-345472-qrddwebe	83	15	levels	level	NNS
cord-345472-qrddwebe	83	16	of	of	IN
cord-345472-qrddwebe	83	17	inflammatory	inflammatory	JJ
cord-345472-qrddwebe	83	18	cytokines	cytokine	NNS
cord-345472-qrddwebe	83	19	)	)	-RRB-
cord-345472-qrddwebe	83	20	,	,	,
cord-345472-qrddwebe	83	21	mucus	mucus	NN
cord-345472-qrddwebe	83	22	hypersecretion	hypersecretion	NN
cord-345472-qrddwebe	83	23	,	,	,
cord-345472-qrddwebe	83	24	and	and	CC
cord-345472-qrddwebe	83	25	oedema	oedema	NN
cord-345472-qrddwebe	83	26	in	in	IN
cord-345472-qrddwebe	83	27	the	the	DT
cord-345472-qrddwebe	83	28	airways	airways	NNPS
cord-345472-qrddwebe	83	29	[	[	-LRB-
cord-345472-qrddwebe	83	30	1	1	CD
cord-345472-qrddwebe	83	31	,	,	,
cord-345472-qrddwebe	83	32	9	9	CD
cord-345472-qrddwebe	83	33	,	,	,
cord-345472-qrddwebe	83	34	66	66	CD
cord-345472-qrddwebe	83	35	]	]	-RRB-
cord-345472-qrddwebe	83	36	.	.	.
cord-345472-qrddwebe	84	1	In	in	IN
cord-345472-qrddwebe	84	2	severe	severe	JJ
cord-345472-qrddwebe	84	3	cases	case	NNS
cord-345472-qrddwebe	84	4	,	,	,
cord-345472-qrddwebe	84	5	increased	increase	VBN
cord-345472-qrddwebe	84	6	mucus	mucus	NN
cord-345472-qrddwebe	84	7	production	production	NN
cord-345472-qrddwebe	84	8	and	and	CC
cord-345472-qrddwebe	84	9	deposition	deposition	NN
cord-345472-qrddwebe	84	10	of	of	IN
cord-345472-qrddwebe	84	11	cellular	cellular	JJ
cord-345472-qrddwebe	84	12	debris	debris	NN
cord-345472-qrddwebe	84	13	can	can	MD
cord-345472-qrddwebe	84	14	occlude	occlude	VB
cord-345472-qrddwebe	84	15	the	the	DT
cord-345472-qrddwebe	84	16	bronchiole	bronchiole	NNP
cord-345472-qrddwebe	84	17	lumen	lumen	NN
cord-345472-qrddwebe	84	18	,	,	,
cord-345472-qrddwebe	84	19	contributing	contribute	VBG
cord-345472-qrddwebe	84	20	to	to	IN
cord-345472-qrddwebe	84	21	bronchiolar	bronchiolar	JJ
cord-345472-qrddwebe	84	22	obstruction	obstruction	NN
cord-345472-qrddwebe	84	23	,	,	,
cord-345472-qrddwebe	84	24	air	air	NN
cord-345472-qrddwebe	84	25	trapping	trapping	NN
cord-345472-qrddwebe	84	26	,	,	,
cord-345472-qrddwebe	84	27	and	and	CC
cord-345472-qrddwebe	84	28	lobar	lobar	NN
cord-345472-qrddwebe	84	29	collapse	collapse	NN
cord-345472-qrddwebe	84	30	[	[	-LRB-
cord-345472-qrddwebe	84	31	9	9	CD
cord-345472-qrddwebe	84	32	]	]	-RRB-
cord-345472-qrddwebe	84	33	.	.	.
cord-345472-qrddwebe	85	1	Patients	patient	NNS
cord-345472-qrddwebe	85	2	with	with	IN
cord-345472-qrddwebe	85	3	severe	severe	JJ
cord-345472-qrddwebe	85	4	disease	disease	NN
cord-345472-qrddwebe	85	5	experience	experience	NN
cord-345472-qrddwebe	85	6	dyspnea	dyspnea	NN
cord-345472-qrddwebe	85	7	,	,	,
cord-345472-qrddwebe	85	8	wheezing	wheezing	NN
cord-345472-qrddwebe	85	9	,	,	,
cord-345472-qrddwebe	85	10	and	and	CC
cord-345472-qrddwebe	85	11	cough	cough	NN
cord-345472-qrddwebe	85	12	,	,	,
cord-345472-qrddwebe	85	13	the	the	DT
cord-345472-qrddwebe	85	14	latter	latter	JJ
cord-345472-qrddwebe	85	15	often	often	RB
cord-345472-qrddwebe	85	16	persisting	persist	VBG
cord-345472-qrddwebe	85	17	for	for	IN
cord-345472-qrddwebe	85	18	three	three	CD
cord-345472-qrddwebe	85	19	or	or	CC
cord-345472-qrddwebe	85	20	more	more	JJR
cord-345472-qrddwebe	85	21	weeks	week	NNS
cord-345472-qrddwebe	85	22	.	.	.
cord-345472-qrddwebe	86	1	Mild	mild	JJ
cord-345472-qrddwebe	86	2	cases	case	NNS
cord-345472-qrddwebe	86	3	of	of	IN
cord-345472-qrddwebe	86	4	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	86	5	are	be	VBP
cord-345472-qrddwebe	86	6	manageable	manageable	JJ
cord-345472-qrddwebe	86	7	in	in	IN
cord-345472-qrddwebe	86	8	outpatient	outpatient	NN
cord-345472-qrddwebe	86	9	departments	department	NNS
cord-345472-qrddwebe	86	10	.	.	.
cord-345472-qrddwebe	87	1	However	however	RB
cord-345472-qrddwebe	87	2	,	,	,
cord-345472-qrddwebe	87	3	severe	severe	JJ
cord-345472-qrddwebe	87	4	disease	disease	NN
cord-345472-qrddwebe	87	5	can	can	MD
cord-345472-qrddwebe	87	6	be	be	VB
cord-345472-qrddwebe	87	7	life	life	NN
cord-345472-qrddwebe	87	8	threatening	threaten	VBG
cord-345472-qrddwebe	87	9	,	,	,
cord-345472-qrddwebe	87	10	necessitating	necessitate	VBG
cord-345472-qrddwebe	87	11	urgent	urgent	JJ
cord-345472-qrddwebe	87	12	mechanical	mechanical	JJ
cord-345472-qrddwebe	87	13	ventilation	ventilation	NN
cord-345472-qrddwebe	87	14	and	and	CC
cord-345472-qrddwebe	87	15	admission	admission	NN
cord-345472-qrddwebe	87	16	to	to	IN
cord-345472-qrddwebe	87	17	intensive	intensive	JJ
cord-345472-qrddwebe	87	18	care	care	NN
cord-345472-qrddwebe	87	19	units	unit	NNS
cord-345472-qrddwebe	87	20	for	for	IN
cord-345472-qrddwebe	87	21	some	some	DT
cord-345472-qrddwebe	87	22	patients	patient	NNS
cord-345472-qrddwebe	87	23	.	.	.
cord-345472-qrddwebe	88	1	Individuals	individual	NNS
cord-345472-qrddwebe	88	2	with	with	IN
cord-345472-qrddwebe	88	3	severe	severe	JJ
cord-345472-qrddwebe	88	4	RSV	rsv	NN
cord-345472-qrddwebe	88	5	-	-	HYPH
cord-345472-qrddwebe	88	6	induced	induce	VBN
cord-345472-qrddwebe	88	7	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	88	8	during	during	IN
cord-345472-qrddwebe	88	9	infancy	infancy	NN
cord-345472-qrddwebe	88	10	are	be	VBP
cord-345472-qrddwebe	88	11	more	more	RBR
cord-345472-qrddwebe	88	12	likely	likely	JJ
cord-345472-qrddwebe	88	13	to	to	TO
cord-345472-qrddwebe	88	14	develop	develop	VB
cord-345472-qrddwebe	88	15	impaired	impaired	JJ
cord-345472-qrddwebe	88	16	lung	lung	NN
cord-345472-qrddwebe	88	17	function	function	NN
cord-345472-qrddwebe	88	18	,	,	,
cord-345472-qrddwebe	88	19	recurrent	recurrent	JJ
cord-345472-qrddwebe	88	20	wheezing	wheeze	VBG
cord-345472-qrddwebe	88	21	,	,	,
cord-345472-qrddwebe	88	22	and	and	CC
cord-345472-qrddwebe	88	23	asthma	asthma	NN
cord-345472-qrddwebe	88	24	in	in	IN
cord-345472-qrddwebe	88	25	adulthood	adulthood	NN
cord-345472-qrddwebe	88	26	[	[	-LRB-
cord-345472-qrddwebe	88	27	67	67	CD
cord-345472-qrddwebe	88	28	]	]	-RRB-
cord-345472-qrddwebe	88	29	.	.	.
cord-345472-qrddwebe	89	1	Whether	whether	IN
cord-345472-qrddwebe	89	2	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	89	3	play	play	VBP
cord-345472-qrddwebe	89	4	a	a	DT
cord-345472-qrddwebe	89	5	beneficial	beneficial	JJ
cord-345472-qrddwebe	89	6	or	or	CC
cord-345472-qrddwebe	89	7	detrimental	detrimental	JJ
cord-345472-qrddwebe	89	8	role	role	NN
cord-345472-qrddwebe	89	9	during	during	IN
cord-345472-qrddwebe	89	10	RSV	RSV	NNP
cord-345472-qrddwebe	89	11	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	89	12	remains	remain	VBZ
cord-345472-qrddwebe	89	13	difficult	difficult	JJ
cord-345472-qrddwebe	89	14	to	to	TO
cord-345472-qrddwebe	89	15	ascertain	ascertain	VB
cord-345472-qrddwebe	89	16	clinically	clinically	RB
cord-345472-qrddwebe	89	17	due	due	JJ
cord-345472-qrddwebe	89	18	to	to	IN
cord-345472-qrddwebe	89	19	difficulties	difficulty	NNS
cord-345472-qrddwebe	89	20	in	in	IN
cord-345472-qrddwebe	89	21	sampling	sample	VBG
cord-345472-qrddwebe	89	22	young	young	JJ
cord-345472-qrddwebe	89	23	infants	infant	NNS
cord-345472-qrddwebe	89	24	.	.	.
cord-345472-qrddwebe	90	1	However	however	RB
cord-345472-qrddwebe	90	2	,	,	,
cord-345472-qrddwebe	90	3	the	the	DT
cord-345472-qrddwebe	90	4	predominance	predominance	NN
cord-345472-qrddwebe	90	5	of	of	IN
cord-345472-qrddwebe	90	6	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	90	7	in	in	IN
cord-345472-qrddwebe	90	8	the	the	DT
cord-345472-qrddwebe	90	9	airway	airway	NN
cord-345472-qrddwebe	90	10	wall	wall	NN
cord-345472-qrddwebe	90	11	and	and	CC
cord-345472-qrddwebe	90	12	alveoli	alveolus	NNS
cord-345472-qrddwebe	90	13	of	of	IN
cord-345472-qrddwebe	90	14	lung	lung	NN
cord-345472-qrddwebe	90	15	autopsy	autopsy	JJ
cord-345472-qrddwebe	90	16	samples	sample	NNS
cord-345472-qrddwebe	90	17	from	from	IN
cord-345472-qrddwebe	90	18	fatal	fatal	JJ
cord-345472-qrddwebe	90	19	cases	case	NNS
cord-345472-qrddwebe	90	20	of	of	IN
cord-345472-qrddwebe	90	21	RSV	RSV	NNP
cord-345472-qrddwebe	90	22	-	-	HYPH
cord-345472-qrddwebe	90	23	related	relate	VBN
cord-345472-qrddwebe	90	24	LRI	LRI	NNP
cord-345472-qrddwebe	90	25	[	[	-LRB-
cord-345472-qrddwebe	90	26	9	9	CD
cord-345472-qrddwebe	90	27	,	,	,
cord-345472-qrddwebe	90	28	68	68	CD
cord-345472-qrddwebe	90	29	]	]	-RRB-
cord-345472-qrddwebe	90	30	or	or	CC
cord-345472-qrddwebe	90	31	in	in	IN
cord-345472-qrddwebe	90	32	the	the	DT
cord-345472-qrddwebe	90	33	airways	airway	NNS
cord-345472-qrddwebe	90	34	of	of	IN
cord-345472-qrddwebe	90	35	paediatric	paediatric	JJ
cord-345472-qrddwebe	90	36	patients	patient	NNS
cord-345472-qrddwebe	90	37	(	(	-LRB-
cord-345472-qrddwebe	90	38	~80	~80	CD
cord-345472-qrddwebe	90	39	%	%	NN
cord-345472-qrddwebe	90	40	of	of	IN
cord-345472-qrddwebe	90	41	the	the	DT
cord-345472-qrddwebe	90	42	total	total	JJ
cord-345472-qrddwebe	90	43	cell	cell	NN
cord-345472-qrddwebe	90	44	infiltrate	infiltrate	NN
cord-345472-qrddwebe	90	45	)	)	-RRB-
cord-345472-qrddwebe	90	46	with	with	IN
cord-345472-qrddwebe	90	47	severe	severe	JJ
cord-345472-qrddwebe	90	48	RSV	rsv	NN
cord-345472-qrddwebe	90	49	-	-	HYPH
cord-345472-qrddwebe	90	50	induced	induce	VBN
cord-345472-qrddwebe	90	51	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	90	52	[	[	-LRB-
cord-345472-qrddwebe	90	53	8	8	CD
cord-345472-qrddwebe	90	54	]	]	-RRB-
cord-345472-qrddwebe	90	55	would	would	MD
cord-345472-qrddwebe	90	56	suggest	suggest	VB
cord-345472-qrddwebe	90	57	that	that	IN
cord-345472-qrddwebe	90	58	they	-PRON-	PRP
cord-345472-qrddwebe	90	59	are	be	VBP
cord-345472-qrddwebe	90	60	not	not	RB
cord-345472-qrddwebe	90	61	innocent	innocent	JJ
cord-345472-qrddwebe	90	62	bystanders	bystander	NNS
cord-345472-qrddwebe	90	63	.	.	.
cord-345472-qrddwebe	91	1	We	-PRON-	PRP
cord-345472-qrddwebe	91	2	postulate	postulate	VBP
cord-345472-qrddwebe	91	3	that	that	IN
cord-345472-qrddwebe	91	4	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	91	5	promote	promote	VBP
cord-345472-qrddwebe	91	6	lung	lung	NN
cord-345472-qrddwebe	91	7	pathophysiology	pathophysiology	NN
cord-345472-qrddwebe	91	8	during	during	IN
cord-345472-qrddwebe	91	9	RSV	RSV	NNP
cord-345472-qrddwebe	91	10	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	91	11	through	through	IN
cord-345472-qrddwebe	91	12	the	the	DT
cord-345472-qrddwebe	91	13	production	production	NN
cord-345472-qrddwebe	91	14	of	of	IN
cord-345472-qrddwebe	91	15	pro	pro	JJ
cord-345472-qrddwebe	91	16	-	-	JJ
cord-345472-qrddwebe	91	17	inflammatory	inflammatory	JJ
cord-345472-qrddwebe	91	18	cytokines	cytokine	NNS
cord-345472-qrddwebe	91	19	and	and	CC
cord-345472-qrddwebe	91	20	the	the	DT
cord-345472-qrddwebe	91	21	releasing	releasing	NN
cord-345472-qrddwebe	91	22	of	of	IN
cord-345472-qrddwebe	91	23	cytotoxic	cytotoxic	JJ
cord-345472-qrddwebe	91	24	molecules	molecule	NNS
cord-345472-qrddwebe	91	25	(	(	-LRB-
cord-345472-qrddwebe	91	26	illustrated	illustrate	VBN
cord-345472-qrddwebe	91	27	in	in	IN
cord-345472-qrddwebe	91	28	Figure	Figure	NNP
cord-345472-qrddwebe	91	29	1	1	CD
cord-345472-qrddwebe	91	30	)	)	-RRB-
cord-345472-qrddwebe	91	31	.	.	.
cord-345472-qrddwebe	92	1	These	these	DT
cord-345472-qrddwebe	92	2	products	product	NNS
cord-345472-qrddwebe	92	3	,	,	,
cord-345472-qrddwebe	92	4	released	release	VBN
cord-345472-qrddwebe	92	5	through	through	IN
cord-345472-qrddwebe	92	6	distinct	distinct	JJ
cord-345472-qrddwebe	92	7	cellular	cellular	JJ
cord-345472-qrddwebe	92	8	processes	process	NNS
cord-345472-qrddwebe	92	9	(	(	-LRB-
cord-345472-qrddwebe	92	10	e.g.	e.g.	RB
cord-345472-qrddwebe	92	11	,	,	,
cord-345472-qrddwebe	92	12	NETosis	NETosis	NNP
cord-345472-qrddwebe	92	13	,	,	,
cord-345472-qrddwebe	92	14	degranulation	degranulation	NN
cord-345472-qrddwebe	92	15	)	)	-RRB-
cord-345472-qrddwebe	92	16	contribute	contribute	VBP
cord-345472-qrddwebe	92	17	to	to	IN
cord-345472-qrddwebe	92	18	mucus	mucus	NN
cord-345472-qrddwebe	92	19	hyperproduction	hyperproduction	NN
cord-345472-qrddwebe	92	20	,	,	,
cord-345472-qrddwebe	92	21	airway	airway	JJ
cord-345472-qrddwebe	92	22	epithelial	epithelial	JJ
cord-345472-qrddwebe	92	23	cell	cell	NN
cord-345472-qrddwebe	92	24	(	(	-LRB-
cord-345472-qrddwebe	92	25	AEC	AEC	NNP
cord-345472-qrddwebe	92	26	)	)	-RRB-
cord-345472-qrddwebe	92	27	death	death	NN
cord-345472-qrddwebe	92	28	and	and	CC
cord-345472-qrddwebe	92	29	sloughing	sloughing	NN
cord-345472-qrddwebe	92	30	,	,	,
cord-345472-qrddwebe	92	31	and	and	CC
cord-345472-qrddwebe	92	32	oedema	oedema	NN
cord-345472-qrddwebe	92	33	(	(	-LRB-
cord-345472-qrddwebe	92	34	Figure	figure	NN
cord-345472-qrddwebe	92	35	1	1	CD
cord-345472-qrddwebe	92	36	)	)	-RRB-
cord-345472-qrddwebe	92	37	.	.	.
cord-345472-qrddwebe	93	1	In	in	IN
cord-345472-qrddwebe	93	2	RSV	RSV	NNP
cord-345472-qrddwebe	93	3	-	-	HYPH
cord-345472-qrddwebe	93	4	infected	infect	VBN
cord-345472-qrddwebe	93	5	mice	mouse	NNS
cord-345472-qrddwebe	93	6	,	,	,
cord-345472-qrddwebe	93	7	the	the	DT
cord-345472-qrddwebe	93	8	depletion	depletion	NN
cord-345472-qrddwebe	93	9	of	of	IN
cord-345472-qrddwebe	93	10	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	93	11	decreases	decrease	VBZ
cord-345472-qrddwebe	93	12	NE	NE	NNP
cord-345472-qrddwebe	93	13	,	,	,
cord-345472-qrddwebe	93	14	MPO	MPO	NNP
cord-345472-qrddwebe	93	15	,	,	,
cord-345472-qrddwebe	93	16	and	and	CC
cord-345472-qrddwebe	93	17	MMP9	MMP9	NNP
cord-345472-qrddwebe	93	18	levels	level	NNS
cord-345472-qrddwebe	93	19	in	in	IN
cord-345472-qrddwebe	93	20	the	the	DT
cord-345472-qrddwebe	93	21	airways	airways	NNPS
cord-345472-qrddwebe	93	22	[	[	-LRB-
cord-345472-qrddwebe	93	23	69	69	CD
cord-345472-qrddwebe	93	24	]	]	-RRB-
cord-345472-qrddwebe	93	25	.	.	.
cord-345472-qrddwebe	94	1	Depletion	depletion	NN
cord-345472-qrddwebe	94	2	of	of	IN
cord-345472-qrddwebe	94	3	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	94	4	has	have	VBZ
cord-345472-qrddwebe	94	5	also	also	RB
cord-345472-qrddwebe	94	6	been	be	VBN
cord-345472-qrddwebe	94	7	shown	show	VBN
cord-345472-qrddwebe	94	8	to	to	TO
cord-345472-qrddwebe	94	9	lower	lower	VB
cord-345472-qrddwebe	94	10	TNFα	TNFα	NNS
cord-345472-qrddwebe	94	11	levels	level	NNS
cord-345472-qrddwebe	94	12	and	and	CC
cord-345472-qrddwebe	94	13	attenuate	attenuate	VB
cord-345472-qrddwebe	94	14	airway	airway	NN
cord-345472-qrddwebe	94	15	mucin	mucin	NN
cord-345472-qrddwebe	94	16	production	production	NN
cord-345472-qrddwebe	94	17	in	in	IN
cord-345472-qrddwebe	94	18	the	the	DT
cord-345472-qrddwebe	94	19	lungs	lung	NNS
cord-345472-qrddwebe	94	20	of	of	IN
cord-345472-qrddwebe	94	21	RSV	RSV	NNP
cord-345472-qrddwebe	94	22	infected	infect	VBN
cord-345472-qrddwebe	94	23	mice	mouse	NNS
cord-345472-qrddwebe	94	24	[	[	-LRB-
cord-345472-qrddwebe	94	25	70	70	CD
cord-345472-qrddwebe	94	26	]	]	-RRB-
cord-345472-qrddwebe	94	27	.	.	.
cord-345472-qrddwebe	95	1	In	in	IN
cord-345472-qrddwebe	95	2	addition	addition	NN
cord-345472-qrddwebe	95	3	,	,	,
cord-345472-qrddwebe	95	4	in	in	IN
cord-345472-qrddwebe	95	5	vivo	vivo	NN
cord-345472-qrddwebe	95	6	antagonism	antagonism	NN
cord-345472-qrddwebe	95	7	of	of	IN
cord-345472-qrddwebe	95	8	CXCR2	CXCR2	NNP
cord-345472-qrddwebe	95	9	(	(	-LRB-
cord-345472-qrddwebe	95	10	a	a	DT
cord-345472-qrddwebe	95	11	chemokine	chemokine	NN
cord-345472-qrddwebe	95	12	receptor	receptor	NN
cord-345472-qrddwebe	95	13	important	important	JJ
cord-345472-qrddwebe	95	14	for	for	IN
cord-345472-qrddwebe	95	15	neutrophil	neutrophil	NN
cord-345472-qrddwebe	95	16	recruitment	recruitment	NN
cord-345472-qrddwebe	95	17	into	into	IN
cord-345472-qrddwebe	95	18	the	the	DT
cord-345472-qrddwebe	95	19	lung	lung	NN
cord-345472-qrddwebe	95	20	)	)	-RRB-
cord-345472-qrddwebe	95	21	reduces	reduce	VBZ
cord-345472-qrddwebe	95	22	mucus	mucus	NN
cord-345472-qrddwebe	95	23	production	production	NN
cord-345472-qrddwebe	95	24	in	in	IN
cord-345472-qrddwebe	95	25	the	the	DT
cord-345472-qrddwebe	95	26	airways	airway	NNS
cord-345472-qrddwebe	95	27	of	of	IN
cord-345472-qrddwebe	95	28	RSV	RSV	NNP
cord-345472-qrddwebe	95	29	-	-	HYPH
cord-345472-qrddwebe	95	30	infected	infect	VBN
cord-345472-qrddwebe	95	31	mice	mouse	NNS
cord-345472-qrddwebe	95	32	[	[	-LRB-
cord-345472-qrddwebe	95	33	71	71	CD
cord-345472-qrddwebe	95	34	]	]	-RRB-
cord-345472-qrddwebe	95	35	.	.	.
cord-345472-qrddwebe	96	1	In	in	IN
cord-345472-qrddwebe	96	2	vitro	vitro	FW
cord-345472-qrddwebe	96	3	,	,	,
cord-345472-qrddwebe	96	4	co	co	NN
cord-345472-qrddwebe	96	5	-	-	NN
cord-345472-qrddwebe	96	6	culture	culture	NN
cord-345472-qrddwebe	96	7	of	of	IN
cord-345472-qrddwebe	96	8	RSV	RSV	NNP
cord-345472-qrddwebe	96	9	-	-	HYPH
cord-345472-qrddwebe	96	10	infected	infect	VBN
cord-345472-qrddwebe	96	11	AECs	aec	NNS
cord-345472-qrddwebe	96	12	with	with	IN
cord-345472-qrddwebe	96	13	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	96	14	increases	increase	VBZ
cord-345472-qrddwebe	96	15	AEC	AEC	NNP
cord-345472-qrddwebe	96	16	damage	damage	NN
cord-345472-qrddwebe	96	17	compared	compare	VBN
cord-345472-qrddwebe	96	18	with	with	IN
cord-345472-qrddwebe	96	19	RSV	RSV	NNP
cord-345472-qrddwebe	96	20	-	-	HYPH
cord-345472-qrddwebe	96	21	infected	infect	VBN
cord-345472-qrddwebe	96	22	AECs	aec	NNS
cord-345472-qrddwebe	96	23	cultured	culture	VBN
cord-345472-qrddwebe	96	24	without	without	IN
cord-345472-qrddwebe	96	25	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	96	26	[	[	-LRB-
cord-345472-qrddwebe	96	27	72	72	CD
cord-345472-qrddwebe	96	28	]	]	-RRB-
cord-345472-qrddwebe	96	29	.	.	.
cord-345472-qrddwebe	97	1	Collectively	collectively	RB
cord-345472-qrddwebe	97	2	,	,	,
cord-345472-qrddwebe	97	3	these	these	DT
cord-345472-qrddwebe	97	4	findings	finding	NNS
cord-345472-qrddwebe	97	5	suggest	suggest	VBP
cord-345472-qrddwebe	97	6	that	that	IN
cord-345472-qrddwebe	97	7	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	97	8	can	can	MD
cord-345472-qrddwebe	97	9	contribute	contribute	VB
cord-345472-qrddwebe	97	10	to	to	IN
cord-345472-qrddwebe	97	11	pathogenesis	pathogenesis	NN
cord-345472-qrddwebe	97	12	;	;	:
cord-345472-qrddwebe	97	13	however	however	RB
cord-345472-qrddwebe	97	14	,	,	,
cord-345472-qrddwebe	97	15	a	a	DT
cord-345472-qrddwebe	97	16	limitation	limitation	NN
cord-345472-qrddwebe	97	17	of	of	IN
cord-345472-qrddwebe	97	18	modelling	model	VBG
cord-345472-qrddwebe	97	19	RSV	RSV	NNP
cord-345472-qrddwebe	97	20	in	in	IN
cord-345472-qrddwebe	97	21	mice	mice	NN
cord-345472-qrddwebe	97	22	is	be	VBZ
cord-345472-qrddwebe	97	23	that	that	IN
cord-345472-qrddwebe	97	24	the	the	DT
cord-345472-qrddwebe	97	25	virus	virus	NN
cord-345472-qrddwebe	97	26	replicates	replicate	VBZ
cord-345472-qrddwebe	97	27	poorly	poorly	RB
cord-345472-qrddwebe	97	28	,	,	,
cord-345472-qrddwebe	97	29	and	and	CC
cord-345472-qrddwebe	97	30	hence	hence	RB
cord-345472-qrddwebe	97	31	this	this	DT
cord-345472-qrddwebe	97	32	is	be	VBZ
cord-345472-qrddwebe	97	33	not	not	RB
cord-345472-qrddwebe	97	34	a	a	DT
cord-345472-qrddwebe	97	35	particularly	particularly	RB
cord-345472-qrddwebe	97	36	tractable	tractable	JJ
cord-345472-qrddwebe	97	37	system	system	NN
cord-345472-qrddwebe	97	38	to	to	TO
cord-345472-qrddwebe	97	39	assess	assess	VB
cord-345472-qrddwebe	97	40	the	the	DT
cord-345472-qrddwebe	97	41	beneficial	beneficial	JJ
cord-345472-qrddwebe	97	42	properties	property	NNS
cord-345472-qrddwebe	97	43	of	of	IN
cord-345472-qrddwebe	97	44	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	97	45	,	,	,
cord-345472-qrddwebe	97	46	such	such	JJ
cord-345472-qrddwebe	97	47	as	as	IN
cord-345472-qrddwebe	97	48	their	-PRON-	PRP$
cord-345472-qrddwebe	97	49	antiviral	antiviral	JJ
cord-345472-qrddwebe	97	50	activities	activity	NNS
cord-345472-qrddwebe	97	51	.	.	.
cord-345472-qrddwebe	98	1	(	(	-LRB-
cord-345472-qrddwebe	98	2	1	1	CD
cord-345472-qrddwebe	98	3	)	)	-RRB-
cord-345472-qrddwebe	98	4	,	,	,
cord-345472-qrddwebe	98	5	degranulation	degranulation	NN
cord-345472-qrddwebe	98	6	(	(	-LRB-
cord-345472-qrddwebe	98	7	2	2	CD
cord-345472-qrddwebe	98	8	)	)	-RRB-
cord-345472-qrddwebe	98	9	,	,	,
cord-345472-qrddwebe	98	10	respiratory	respiratory	JJ
cord-345472-qrddwebe	98	11	oxygen	oxygen	NN
cord-345472-qrddwebe	98	12	species	specie	NNS
cord-345472-qrddwebe	98	13	(	(	-LRB-
cord-345472-qrddwebe	98	14	ROS	ROS	NNP
cord-345472-qrddwebe	98	15	)	)	-RRB-
cord-345472-qrddwebe	98	16	production	production	NN
cord-345472-qrddwebe	98	17	(	(	-LRB-
cord-345472-qrddwebe	98	18	3	3	CD
cord-345472-qrddwebe	98	19	)	)	-RRB-
cord-345472-qrddwebe	98	20	,	,	,
cord-345472-qrddwebe	98	21	and	and	CC
cord-345472-qrddwebe	98	22	the	the	DT
cord-345472-qrddwebe	98	23	release	release	NN
cord-345472-qrddwebe	98	24	of	of	IN
cord-345472-qrddwebe	98	25	neutrophil	neutrophil	NN
cord-345472-qrddwebe	98	26	extracellular	extracellular	JJ
cord-345472-qrddwebe	98	27	traps	trap	NNS
cord-345472-qrddwebe	98	28	(	(	-LRB-
cord-345472-qrddwebe	98	29	NETosis	NETosis	NNP
cord-345472-qrddwebe	98	30	)	)	-RRB-
cord-345472-qrddwebe	98	31	(	(	-LRB-
cord-345472-qrddwebe	98	32	4	4	LS
cord-345472-qrddwebe	98	33	)	)	-RRB-
cord-345472-qrddwebe	98	34	are	be	VBP
cord-345472-qrddwebe	98	35	associated	associate	VBN
cord-345472-qrddwebe	98	36	with	with	IN
cord-345472-qrddwebe	98	37	increased	increase	VBN
cord-345472-qrddwebe	98	38	lung	lung	NN
cord-345472-qrddwebe	98	39	inflammation	inflammation	NN
cord-345472-qrddwebe	98	40	,	,	,
cord-345472-qrddwebe	98	41	systemic	systemic	JJ
cord-345472-qrddwebe	98	42	fever	fever	NN
cord-345472-qrddwebe	98	43	,	,	,
cord-345472-qrddwebe	98	44	mucus	mucus	NN
cord-345472-qrddwebe	98	45	hypersecretion	hypersecretion	NN
cord-345472-qrddwebe	98	46	,	,	,
cord-345472-qrddwebe	98	47	airway	airway	NN
cord-345472-qrddwebe	98	48	obstruction	obstruction	NN
cord-345472-qrddwebe	98	49	,	,	,
cord-345472-qrddwebe	98	50	and	and	CC
cord-345472-qrddwebe	98	51	epithelial	epithelial	JJ
cord-345472-qrddwebe	98	52	cell	cell	NN
cord-345472-qrddwebe	98	53	death	death	NN
cord-345472-qrddwebe	98	54	.	.	.
cord-345472-qrddwebe	99	1	Together	together	RB
cord-345472-qrddwebe	99	2	,	,	,
cord-345472-qrddwebe	99	3	these	these	DT
cord-345472-qrddwebe	99	4	factors	factor	NNS
cord-345472-qrddwebe	99	5	contribute	contribute	VBP
cord-345472-qrddwebe	99	6	to	to	IN
cord-345472-qrddwebe	99	7	increased	increase	VBN
cord-345472-qrddwebe	99	8	lung	lung	NN
cord-345472-qrddwebe	99	9	damage	damage	NN
cord-345472-qrddwebe	99	10	during	during	IN
cord-345472-qrddwebe	99	11	severe	severe	JJ
cord-345472-qrddwebe	99	12	RSV	RSV	NNP
cord-345472-qrddwebe	99	13	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	99	14	.	.	.
cord-345472-qrddwebe	100	1	Infantile	infantile	JJ
cord-345472-qrddwebe	100	2	severe	severe	JJ
cord-345472-qrddwebe	100	3	viral	viral	JJ
cord-345472-qrddwebe	100	4	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	100	5	remains	remain	VBZ
cord-345472-qrddwebe	100	6	a	a	DT
cord-345472-qrddwebe	100	7	major	major	JJ
cord-345472-qrddwebe	100	8	risk	risk	NN
cord-345472-qrddwebe	100	9	factor	factor	NN
cord-345472-qrddwebe	100	10	for	for	IN
cord-345472-qrddwebe	100	11	persistent	persistent	JJ
cord-345472-qrddwebe	100	12	wheezing	wheezing	NN
cord-345472-qrddwebe	100	13	and	and	CC
cord-345472-qrddwebe	100	14	chronic	chronic	JJ
cord-345472-qrddwebe	100	15	asthma	asthma	NN
cord-345472-qrddwebe	100	16	in	in	IN
cord-345472-qrddwebe	100	17	childhood	childhood	NN
cord-345472-qrddwebe	100	18	[	[	-LRB-
cord-345472-qrddwebe	100	19	73	73	CD
cord-345472-qrddwebe	100	20	,	,	,
cord-345472-qrddwebe	100	21	74	74	CD
cord-345472-qrddwebe	100	22	]	]	-RRB-
cord-345472-qrddwebe	100	23	.	.	.
cord-345472-qrddwebe	101	1	Therefore	therefore	RB
cord-345472-qrddwebe	101	2	,	,	,
cord-345472-qrddwebe	101	3	excessive	excessive	JJ
cord-345472-qrddwebe	101	4	neutrophilic	neutrophilic	JJ
cord-345472-qrddwebe	101	5	inflammation	inflammation	NN
cord-345472-qrddwebe	101	6	in	in	IN
cord-345472-qrddwebe	101	7	infants	infant	NNS
cord-345472-qrddwebe	101	8	with	with	IN
cord-345472-qrddwebe	101	9	severe	severe	JJ
cord-345472-qrddwebe	101	10	RSV	RSV	NNP
cord-345472-qrddwebe	101	11	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	101	12	may	may	MD
cord-345472-qrddwebe	101	13	contribute	contribute	VB
cord-345472-qrddwebe	101	14	to	to	IN
cord-345472-qrddwebe	101	15	the	the	DT
cord-345472-qrddwebe	101	16	onset	onset	NN
cord-345472-qrddwebe	101	17	of	of	IN
cord-345472-qrddwebe	101	18	type	type	NN
cord-345472-qrddwebe	101	19	2	2	CD
cord-345472-qrddwebe	101	20	inflammation	inflammation	NN
cord-345472-qrddwebe	101	21	and	and	CC
cord-345472-qrddwebe	101	22	cause	cause	VB
cord-345472-qrddwebe	101	23	long	long	JJ
cord-345472-qrddwebe	101	24	-	-	HYPH
cord-345472-qrddwebe	101	25	term	term	NN
cord-345472-qrddwebe	101	26	defects	defect	NNS
cord-345472-qrddwebe	101	27	in	in	IN
cord-345472-qrddwebe	101	28	lung	lung	NN
cord-345472-qrddwebe	101	29	development	development	NN
cord-345472-qrddwebe	101	30	that	that	WDT
cord-345472-qrddwebe	101	31	predispose	predispose	VBP
cord-345472-qrddwebe	101	32	susceptible	susceptible	JJ
cord-345472-qrddwebe	101	33	infants	infant	NNS
cord-345472-qrddwebe	101	34	to	to	IN
cord-345472-qrddwebe	101	35	the	the	DT
cord-345472-qrddwebe	101	36	development	development	NN
cord-345472-qrddwebe	101	37	of	of	IN
cord-345472-qrddwebe	101	38	asthma	asthma	NN
cord-345472-qrddwebe	101	39	in	in	IN
cord-345472-qrddwebe	101	40	later	later	JJ
cord-345472-qrddwebe	101	41	childhood	childhood	NN
cord-345472-qrddwebe	101	42	.	.	.
cord-345472-qrddwebe	102	1	Thus	thus	RB
cord-345472-qrddwebe	102	2	,	,	,
cord-345472-qrddwebe	102	3	regulating	regulate	VBG
cord-345472-qrddwebe	102	4	excessive	excessive	JJ
cord-345472-qrddwebe	102	5	neutrophilic	neutrophilic	JJ
cord-345472-qrddwebe	102	6	responses	response	NNS
cord-345472-qrddwebe	102	7	during	during	IN
cord-345472-qrddwebe	102	8	severe	severe	JJ
cord-345472-qrddwebe	102	9	RSV	rsv	NN
cord-345472-qrddwebe	102	10	-	-	HYPH
cord-345472-qrddwebe	102	11	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	102	12	might	may	MD
cord-345472-qrddwebe	102	13	protect	protect	VB
cord-345472-qrddwebe	102	14	against	against	IN
cord-345472-qrddwebe	102	15	the	the	DT
cord-345472-qrddwebe	102	16	loss	loss	NN
cord-345472-qrddwebe	102	17	of	of	IN
cord-345472-qrddwebe	102	18	lung	lung	NN
cord-345472-qrddwebe	102	19	function	function	NN
cord-345472-qrddwebe	102	20	,	,	,
cord-345472-qrddwebe	102	21	curtail	curtail	VB
cord-345472-qrddwebe	102	22	the	the	DT
cord-345472-qrddwebe	102	23	development	development	NN
cord-345472-qrddwebe	102	24	of	of	IN
cord-345472-qrddwebe	102	25	allergic	allergic	JJ
cord-345472-qrddwebe	102	26	sensitisation	sensitisation	NN
cord-345472-qrddwebe	102	27	,	,	,
cord-345472-qrddwebe	102	28	and	and	CC
cord-345472-qrddwebe	102	29	reduce	reduce	VB
cord-345472-qrddwebe	102	30	the	the	DT
cord-345472-qrddwebe	102	31	prevalence	prevalence	NN
cord-345472-qrddwebe	102	32	of	of	IN
cord-345472-qrddwebe	102	33	asthma	asthma	NN
cord-345472-qrddwebe	102	34	.	.	.
cord-345472-qrddwebe	103	1	In	in	IN
cord-345472-qrddwebe	103	2	light	light	NN
cord-345472-qrddwebe	103	3	of	of	IN
cord-345472-qrddwebe	103	4	this	this	DT
cord-345472-qrddwebe	103	5	,	,	,
cord-345472-qrddwebe	103	6	it	-PRON-	PRP
cord-345472-qrddwebe	103	7	is	be	VBZ
cord-345472-qrddwebe	103	8	important	important	JJ
cord-345472-qrddwebe	103	9	to	to	TO
cord-345472-qrddwebe	103	10	understand	understand	VB
cord-345472-qrddwebe	103	11	(	(	-LRB-
cord-345472-qrddwebe	103	12	1	1	LS
cord-345472-qrddwebe	103	13	)	)	-RRB-
cord-345472-qrddwebe	103	14	the	the	DT
cord-345472-qrddwebe	103	15	molecular	molecular	JJ
cord-345472-qrddwebe	103	16	events	event	NNS
cord-345472-qrddwebe	103	17	governing	govern	VBG
cord-345472-qrddwebe	103	18	neutrophil	neutrophil	NN
cord-345472-qrddwebe	103	19	recruitment	recruitment	NN
cord-345472-qrddwebe	103	20	to	to	IN
cord-345472-qrddwebe	103	21	the	the	DT
cord-345472-qrddwebe	103	22	lung	lung	NN
cord-345472-qrddwebe	103	23	,	,	,
cord-345472-qrddwebe	103	24	(	(	-LRB-
cord-345472-qrddwebe	103	25	2	2	LS
cord-345472-qrddwebe	103	26	)	)	-RRB-
cord-345472-qrddwebe	103	27	the	the	DT
cord-345472-qrddwebe	103	28	type	type	NN
cord-345472-qrddwebe	103	29	of	of	IN
cord-345472-qrddwebe	103	30	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	103	31	recruited	recruit	VBN
cord-345472-qrddwebe	103	32	to	to	IN
cord-345472-qrddwebe	103	33	the	the	DT
cord-345472-qrddwebe	103	34	lung	lung	NN
cord-345472-qrddwebe	103	35	,	,	,
cord-345472-qrddwebe	103	36	(	(	-LRB-
cord-345472-qrddwebe	103	37	3	3	LS
cord-345472-qrddwebe	103	38	)	)	-RRB-
cord-345472-qrddwebe	103	39	the	the	DT
cord-345472-qrddwebe	103	40	molecular	molecular	JJ
cord-345472-qrddwebe	103	41	signals	signal	NNS
cord-345472-qrddwebe	103	42	that	that	WDT
cord-345472-qrddwebe	103	43	control	control	VBP
cord-345472-qrddwebe	103	44	optimal	optimal	JJ
cord-345472-qrddwebe	103	45	neutrophil	neutrophil	NN
cord-345472-qrddwebe	103	46	activation	activation	NN
cord-345472-qrddwebe	103	47	and	and	CC
cord-345472-qrddwebe	103	48	function	function	NN
cord-345472-qrddwebe	103	49	,	,	,
cord-345472-qrddwebe	103	50	and	and	CC
cord-345472-qrddwebe	103	51	(	(	-LRB-
cord-345472-qrddwebe	103	52	4	4	LS
cord-345472-qrddwebe	103	53	)	)	-RRB-
cord-345472-qrddwebe	103	54	whether	whether	IN
cord-345472-qrddwebe	103	55	specific	specific	JJ
cord-345472-qrddwebe	103	56	neutrophil	neutrophil	NN
cord-345472-qrddwebe	103	57	subtypes	subtype	NNS
cord-345472-qrddwebe	103	58	can	can	MD
cord-345472-qrddwebe	103	59	be	be	VB
cord-345472-qrddwebe	103	60	targeted	target	VBN
cord-345472-qrddwebe	103	61	therapeutically	therapeutically	RB
cord-345472-qrddwebe	103	62	to	to	TO
cord-345472-qrddwebe	103	63	improve	improve	VB
cord-345472-qrddwebe	103	64	the	the	DT
cord-345472-qrddwebe	103	65	management	management	NN
cord-345472-qrddwebe	103	66	of	of	IN
cord-345472-qrddwebe	103	67	severe	severe	JJ
cord-345472-qrddwebe	103	68	RSV	RSV	NNP
cord-345472-qrddwebe	103	69	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	103	70	.	.	.
cord-345472-qrddwebe	104	1	We	-PRON-	PRP
cord-345472-qrddwebe	104	2	discuss	discuss	VBP
cord-345472-qrddwebe	104	3	these	these	DT
cord-345472-qrddwebe	104	4	questions	question	NNS
cord-345472-qrddwebe	104	5	in	in	IN
cord-345472-qrddwebe	104	6	the	the	DT
cord-345472-qrddwebe	104	7	sections	section	NNS
cord-345472-qrddwebe	104	8	below	below	RB
cord-345472-qrddwebe	104	9	.	.	.
cord-345472-qrddwebe	105	1	The	the	DT
cord-345472-qrddwebe	105	2	earliest	early	JJS
cord-345472-qrddwebe	105	3	stages	stage	NNS
cord-345472-qrddwebe	105	4	of	of	IN
cord-345472-qrddwebe	105	5	neutrophil	neutrophil	NN
cord-345472-qrddwebe	105	6	recruitment	recruitment	NN
cord-345472-qrddwebe	105	7	are	be	VBP
cord-345472-qrddwebe	105	8	initiated	initiate	VBN
cord-345472-qrddwebe	105	9	by	by	IN
cord-345472-qrddwebe	105	10	DAMPs	damp	NNS
cord-345472-qrddwebe	105	11	(	(	-LRB-
cord-345472-qrddwebe	105	12	Table	table	NN
cord-345472-qrddwebe	105	13	2	2	CD
cord-345472-qrddwebe	105	14	)	)	-RRB-
cord-345472-qrddwebe	105	15	,	,	,
cord-345472-qrddwebe	105	16	including	include	VBG
cord-345472-qrddwebe	105	17	HMGB1	HMGB1	NNP
cord-345472-qrddwebe	105	18	,	,	,
cord-345472-qrddwebe	105	19	DNA	DNA	NNP
cord-345472-qrddwebe	105	20	,	,	,
cord-345472-qrddwebe	105	21	and	and	CC
cord-345472-qrddwebe	105	22	histones	histone	NNS
cord-345472-qrddwebe	105	23	,	,	,
cord-345472-qrddwebe	105	24	which	which	WDT
cord-345472-qrddwebe	105	25	are	be	VBP
cord-345472-qrddwebe	105	26	released	release	VBN
cord-345472-qrddwebe	105	27	by	by	IN
cord-345472-qrddwebe	105	28	damaged	damage	VBN
cord-345472-qrddwebe	105	29	or	or	CC
cord-345472-qrddwebe	105	30	dying	die	VBG
cord-345472-qrddwebe	105	31	cells	cell	NNS
cord-345472-qrddwebe	105	32	[	[	-LRB-
cord-345472-qrddwebe	105	33	75	75	CD
cord-345472-qrddwebe	105	34	]	]	-RRB-
cord-345472-qrddwebe	105	35	.	.	.
cord-345472-qrddwebe	106	1	Indeed	indeed	RB
cord-345472-qrddwebe	106	2	,	,	,
cord-345472-qrddwebe	106	3	HMGB1	HMGB1	NNP
cord-345472-qrddwebe	106	4	is	be	VBZ
cord-345472-qrddwebe	106	5	elevated	elevate	VBN
cord-345472-qrddwebe	106	6	in	in	IN
cord-345472-qrddwebe	106	7	the	the	DT
cord-345472-qrddwebe	106	8	nasopharynx	nasopharynx	NN
cord-345472-qrddwebe	106	9	of	of	IN
cord-345472-qrddwebe	106	10	RSV	RSV	NNP
cord-345472-qrddwebe	106	11	-	-	HYPH
cord-345472-qrddwebe	106	12	infected	infect	VBN
cord-345472-qrddwebe	106	13	children	child	NNS
cord-345472-qrddwebe	106	14	compared	compare	VBN
cord-345472-qrddwebe	106	15	with	with	IN
cord-345472-qrddwebe	106	16	those	those	DT
cord-345472-qrddwebe	106	17	infected	infect	VBN
cord-345472-qrddwebe	106	18	with	with	IN
cord-345472-qrddwebe	106	19	other	other	JJ
cord-345472-qrddwebe	106	20	viruses	virus	NNS
cord-345472-qrddwebe	106	21	[	[	-LRB-
cord-345472-qrddwebe	106	22	76	76	CD
cord-345472-qrddwebe	106	23	]	]	-RRB-
cord-345472-qrddwebe	106	24	.	.	.
cord-345472-qrddwebe	107	1	Animal	animal	NN
cord-345472-qrddwebe	107	2	models	model	NNS
cord-345472-qrddwebe	107	3	of	of	IN
cord-345472-qrddwebe	107	4	RSV	RSV	NNP
cord-345472-qrddwebe	107	5	-	-	HYPH
cord-345472-qrddwebe	107	6	bronchiolitis	bronchiolitis	NNP
cord-345472-qrddwebe	107	7	have	have	VBP
cord-345472-qrddwebe	107	8	improved	improve	VBN
cord-345472-qrddwebe	107	9	our	-PRON-	PRP$
cord-345472-qrddwebe	107	10	knowledge	knowledge	NN
cord-345472-qrddwebe	107	11	on	on	IN
cord-345472-qrddwebe	107	12	the	the	DT
cord-345472-qrddwebe	107	13	mechanisms	mechanism	NNS
cord-345472-qrddwebe	107	14	of	of	IN
cord-345472-qrddwebe	107	15	disease	disease	NN
cord-345472-qrddwebe	107	16	development	development	NN
cord-345472-qrddwebe	107	17	and	and	CC
cord-345472-qrddwebe	107	18	progression	progression	NN
cord-345472-qrddwebe	107	19	(	(	-LRB-
cord-345472-qrddwebe	107	20	reviewed	review	VBN
cord-345472-qrddwebe	107	21	extensively	extensively	RB
cord-345472-qrddwebe	107	22	in	in	IN
cord-345472-qrddwebe	107	23	[	[	-LRB-
cord-345472-qrddwebe	107	24	77	77	CD
cord-345472-qrddwebe	107	25	]	]	-RRB-
cord-345472-qrddwebe	107	26	[	[	-LRB-
cord-345472-qrddwebe	107	27	78	78	CD
cord-345472-qrddwebe	107	28	]	]	-RRB-
cord-345472-qrddwebe	107	29	[	[	-LRB-
cord-345472-qrddwebe	107	30	79	79	CD
cord-345472-qrddwebe	107	31	]	]	-RRB-
cord-345472-qrddwebe	107	32	)	)	-RRB-
cord-345472-qrddwebe	107	33	;	;	:
cord-345472-qrddwebe	107	34	however	however	RB
cord-345472-qrddwebe	107	35	,	,	,
cord-345472-qrddwebe	107	36	as	as	IN
cord-345472-qrddwebe	107	37	Figure	figure	NN
cord-345472-qrddwebe	107	38	1	1	CD
cord-345472-qrddwebe	107	39	.	.	.
cord-345472-qrddwebe	108	1	Potential	potential	JJ
cord-345472-qrddwebe	108	2	roles	role	NNS
cord-345472-qrddwebe	108	3	of	of	IN
cord-345472-qrddwebe	108	4	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	108	5	in	in	IN
cord-345472-qrddwebe	108	6	the	the	DT
cord-345472-qrddwebe	108	7	pathophysiology	pathophysiology	NN
cord-345472-qrddwebe	108	8	of	of	IN
cord-345472-qrddwebe	108	9	severe	severe	JJ
cord-345472-qrddwebe	108	10	respiratory	respiratory	JJ
cord-345472-qrddwebe	108	11	syncytial	syncytial	JJ
cord-345472-qrddwebe	108	12	virus	virus	NN
cord-345472-qrddwebe	108	13	(	(	-LRB-
cord-345472-qrddwebe	108	14	RSV	RSV	NNP
cord-345472-qrddwebe	108	15	)	)	-RRB-
cord-345472-qrddwebe	108	16	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	108	17	.	.	.
cord-345472-qrddwebe	109	1	Excessive	excessive	JJ
cord-345472-qrddwebe	109	2	neutrophil	neutrophil	NN
cord-345472-qrddwebe	109	3	-	-	HYPH
cord-345472-qrddwebe	109	4	derived	derive	VBN
cord-345472-qrddwebe	109	5	inflammatory	inflammatory	JJ
cord-345472-qrddwebe	109	6	cytokine	cytokine	NN
cord-345472-qrddwebe	109	7	production	production	NN
cord-345472-qrddwebe	109	8	(	(	-LRB-
cord-345472-qrddwebe	109	9	1	1	CD
cord-345472-qrddwebe	109	10	)	)	-RRB-
cord-345472-qrddwebe	109	11	,	,	,
cord-345472-qrddwebe	109	12	degranulation	degranulation	NN
cord-345472-qrddwebe	109	13	(	(	-LRB-
cord-345472-qrddwebe	109	14	2	2	CD
cord-345472-qrddwebe	109	15	)	)	-RRB-
cord-345472-qrddwebe	109	16	,	,	,
cord-345472-qrddwebe	109	17	respiratory	respiratory	JJ
cord-345472-qrddwebe	109	18	oxygen	oxygen	NN
cord-345472-qrddwebe	109	19	species	specie	NNS
cord-345472-qrddwebe	109	20	(	(	-LRB-
cord-345472-qrddwebe	109	21	ROS	ROS	NNP
cord-345472-qrddwebe	109	22	)	)	-RRB-
cord-345472-qrddwebe	109	23	production	production	NN
cord-345472-qrddwebe	109	24	(	(	-LRB-
cord-345472-qrddwebe	109	25	3	3	CD
cord-345472-qrddwebe	109	26	)	)	-RRB-
cord-345472-qrddwebe	109	27	,	,	,
cord-345472-qrddwebe	109	28	and	and	CC
cord-345472-qrddwebe	109	29	the	the	DT
cord-345472-qrddwebe	109	30	release	release	NN
cord-345472-qrddwebe	109	31	of	of	IN
cord-345472-qrddwebe	109	32	neutrophil	neutrophil	NN
cord-345472-qrddwebe	109	33	extracellular	extracellular	JJ
cord-345472-qrddwebe	109	34	traps	trap	NNS
cord-345472-qrddwebe	109	35	(	(	-LRB-
cord-345472-qrddwebe	109	36	NETosis	NETosis	NNP
cord-345472-qrddwebe	109	37	)	)	-RRB-
cord-345472-qrddwebe	109	38	(	(	-LRB-
cord-345472-qrddwebe	109	39	4	4	LS
cord-345472-qrddwebe	109	40	)	)	-RRB-
cord-345472-qrddwebe	109	41	are	be	VBP
cord-345472-qrddwebe	109	42	associated	associate	VBN
cord-345472-qrddwebe	109	43	with	with	IN
cord-345472-qrddwebe	109	44	increased	increase	VBN
cord-345472-qrddwebe	109	45	lung	lung	NN
cord-345472-qrddwebe	109	46	inflammation	inflammation	NN
cord-345472-qrddwebe	109	47	,	,	,
cord-345472-qrddwebe	109	48	systemic	systemic	JJ
cord-345472-qrddwebe	109	49	fever	fever	NN
cord-345472-qrddwebe	109	50	,	,	,
cord-345472-qrddwebe	109	51	mucus	mucus	NN
cord-345472-qrddwebe	109	52	hypersecretion	hypersecretion	NN
cord-345472-qrddwebe	109	53	,	,	,
cord-345472-qrddwebe	109	54	airway	airway	NN
cord-345472-qrddwebe	109	55	obstruction	obstruction	NN
cord-345472-qrddwebe	109	56	,	,	,
cord-345472-qrddwebe	109	57	and	and	CC
cord-345472-qrddwebe	109	58	epithelial	epithelial	JJ
cord-345472-qrddwebe	109	59	cell	cell	NN
cord-345472-qrddwebe	109	60	death	death	NN
cord-345472-qrddwebe	109	61	.	.	.
cord-345472-qrddwebe	110	1	Together	together	RB
cord-345472-qrddwebe	110	2	,	,	,
cord-345472-qrddwebe	110	3	these	these	DT
cord-345472-qrddwebe	110	4	factors	factor	NNS
cord-345472-qrddwebe	110	5	contribute	contribute	VBP
cord-345472-qrddwebe	110	6	to	to	IN
cord-345472-qrddwebe	110	7	increased	increase	VBN
cord-345472-qrddwebe	110	8	lung	lung	NN
cord-345472-qrddwebe	110	9	damage	damage	NN
cord-345472-qrddwebe	110	10	during	during	IN
cord-345472-qrddwebe	110	11	severe	severe	JJ
cord-345472-qrddwebe	110	12	RSV	RSV	NNP
cord-345472-qrddwebe	110	13	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	110	14	.	.	.
cord-345472-qrddwebe	111	1	Infantile	infantile	JJ
cord-345472-qrddwebe	111	2	severe	severe	JJ
cord-345472-qrddwebe	111	3	viral	viral	JJ
cord-345472-qrddwebe	111	4	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	111	5	remains	remain	VBZ
cord-345472-qrddwebe	111	6	a	a	DT
cord-345472-qrddwebe	111	7	major	major	JJ
cord-345472-qrddwebe	111	8	risk	risk	NN
cord-345472-qrddwebe	111	9	factor	factor	NN
cord-345472-qrddwebe	111	10	for	for	IN
cord-345472-qrddwebe	111	11	persistent	persistent	JJ
cord-345472-qrddwebe	111	12	wheezing	wheezing	NN
cord-345472-qrddwebe	111	13	and	and	CC
cord-345472-qrddwebe	111	14	chronic	chronic	JJ
cord-345472-qrddwebe	111	15	asthma	asthma	NN
cord-345472-qrddwebe	111	16	in	in	IN
cord-345472-qrddwebe	111	17	childhood	childhood	NN
cord-345472-qrddwebe	111	18	[	[	-LRB-
cord-345472-qrddwebe	111	19	73	73	CD
cord-345472-qrddwebe	111	20	,	,	,
cord-345472-qrddwebe	111	21	74	74	CD
cord-345472-qrddwebe	111	22	]	]	-RRB-
cord-345472-qrddwebe	111	23	.	.	.
cord-345472-qrddwebe	112	1	Therefore	therefore	RB
cord-345472-qrddwebe	112	2	,	,	,
cord-345472-qrddwebe	112	3	excessive	excessive	JJ
cord-345472-qrddwebe	112	4	neutrophilic	neutrophilic	JJ
cord-345472-qrddwebe	112	5	inflammation	inflammation	NN
cord-345472-qrddwebe	112	6	in	in	IN
cord-345472-qrddwebe	112	7	infants	infant	NNS
cord-345472-qrddwebe	112	8	with	with	IN
cord-345472-qrddwebe	112	9	severe	severe	JJ
cord-345472-qrddwebe	112	10	RSV	RSV	NNP
cord-345472-qrddwebe	112	11	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	112	12	may	may	MD
cord-345472-qrddwebe	112	13	contribute	contribute	VB
cord-345472-qrddwebe	112	14	to	to	IN
cord-345472-qrddwebe	112	15	the	the	DT
cord-345472-qrddwebe	112	16	onset	onset	NN
cord-345472-qrddwebe	112	17	of	of	IN
cord-345472-qrddwebe	112	18	type	type	NN
cord-345472-qrddwebe	112	19	2	2	CD
cord-345472-qrddwebe	112	20	inflammation	inflammation	NN
cord-345472-qrddwebe	112	21	and	and	CC
cord-345472-qrddwebe	112	22	cause	cause	VB
cord-345472-qrddwebe	112	23	long	long	JJ
cord-345472-qrddwebe	112	24	-	-	HYPH
cord-345472-qrddwebe	112	25	term	term	NN
cord-345472-qrddwebe	112	26	defects	defect	NNS
cord-345472-qrddwebe	112	27	in	in	IN
cord-345472-qrddwebe	112	28	lung	lung	NN
cord-345472-qrddwebe	112	29	development	development	NN
cord-345472-qrddwebe	112	30	that	that	WDT
cord-345472-qrddwebe	112	31	predispose	predispose	VBP
cord-345472-qrddwebe	112	32	susceptible	susceptible	JJ
cord-345472-qrddwebe	112	33	infants	infant	NNS
cord-345472-qrddwebe	112	34	to	to	IN
cord-345472-qrddwebe	112	35	the	the	DT
cord-345472-qrddwebe	112	36	development	development	NN
cord-345472-qrddwebe	112	37	of	of	IN
cord-345472-qrddwebe	112	38	asthma	asthma	NN
cord-345472-qrddwebe	112	39	in	in	IN
cord-345472-qrddwebe	112	40	later	later	JJ
cord-345472-qrddwebe	112	41	childhood	childhood	NN
cord-345472-qrddwebe	112	42	.	.	.
cord-345472-qrddwebe	113	1	Thus	thus	RB
cord-345472-qrddwebe	113	2	,	,	,
cord-345472-qrddwebe	113	3	regulating	regulate	VBG
cord-345472-qrddwebe	113	4	excessive	excessive	JJ
cord-345472-qrddwebe	113	5	neutrophilic	neutrophilic	JJ
cord-345472-qrddwebe	113	6	responses	response	NNS
cord-345472-qrddwebe	113	7	during	during	IN
cord-345472-qrddwebe	113	8	severe	severe	JJ
cord-345472-qrddwebe	113	9	RSV	rsv	NN
cord-345472-qrddwebe	113	10	-	-	HYPH
cord-345472-qrddwebe	113	11	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	113	12	might	may	MD
cord-345472-qrddwebe	113	13	protect	protect	VB
cord-345472-qrddwebe	113	14	against	against	IN
cord-345472-qrddwebe	113	15	the	the	DT
cord-345472-qrddwebe	113	16	loss	loss	NN
cord-345472-qrddwebe	113	17	of	of	IN
cord-345472-qrddwebe	113	18	lung	lung	NN
cord-345472-qrddwebe	113	19	function	function	NN
cord-345472-qrddwebe	113	20	,	,	,
cord-345472-qrddwebe	113	21	curtail	curtail	VB
cord-345472-qrddwebe	113	22	the	the	DT
cord-345472-qrddwebe	113	23	development	development	NN
cord-345472-qrddwebe	113	24	of	of	IN
cord-345472-qrddwebe	113	25	allergic	allergic	JJ
cord-345472-qrddwebe	113	26	sensitisation	sensitisation	NN
cord-345472-qrddwebe	113	27	,	,	,
cord-345472-qrddwebe	113	28	and	and	CC
cord-345472-qrddwebe	113	29	reduce	reduce	VB
cord-345472-qrddwebe	113	30	the	the	DT
cord-345472-qrddwebe	113	31	prevalence	prevalence	NN
cord-345472-qrddwebe	113	32	of	of	IN
cord-345472-qrddwebe	113	33	asthma	asthma	NN
cord-345472-qrddwebe	113	34	.	.	.
cord-345472-qrddwebe	114	1	In	in	IN
cord-345472-qrddwebe	114	2	light	light	NN
cord-345472-qrddwebe	114	3	of	of	IN
cord-345472-qrddwebe	114	4	this	this	DT
cord-345472-qrddwebe	114	5	,	,	,
cord-345472-qrddwebe	114	6	it	-PRON-	PRP
cord-345472-qrddwebe	114	7	is	be	VBZ
cord-345472-qrddwebe	114	8	important	important	JJ
cord-345472-qrddwebe	114	9	to	to	TO
cord-345472-qrddwebe	114	10	understand	understand	VB
cord-345472-qrddwebe	114	11	(	(	-LRB-
cord-345472-qrddwebe	114	12	1	1	LS
cord-345472-qrddwebe	114	13	)	)	-RRB-
cord-345472-qrddwebe	114	14	the	the	DT
cord-345472-qrddwebe	114	15	molecular	molecular	JJ
cord-345472-qrddwebe	114	16	events	event	NNS
cord-345472-qrddwebe	114	17	governing	govern	VBG
cord-345472-qrddwebe	114	18	neutrophil	neutrophil	NN
cord-345472-qrddwebe	114	19	recruitment	recruitment	NN
cord-345472-qrddwebe	114	20	to	to	IN
cord-345472-qrddwebe	114	21	the	the	DT
cord-345472-qrddwebe	114	22	lung	lung	NN
cord-345472-qrddwebe	114	23	,	,	,
cord-345472-qrddwebe	114	24	(	(	-LRB-
cord-345472-qrddwebe	114	25	2	2	LS
cord-345472-qrddwebe	114	26	)	)	-RRB-
cord-345472-qrddwebe	114	27	the	the	DT
cord-345472-qrddwebe	114	28	type	type	NN
cord-345472-qrddwebe	114	29	of	of	IN
cord-345472-qrddwebe	114	30	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	114	31	recruited	recruit	VBN
cord-345472-qrddwebe	114	32	to	to	IN
cord-345472-qrddwebe	114	33	the	the	DT
cord-345472-qrddwebe	114	34	lung	lung	NN
cord-345472-qrddwebe	114	35	,	,	,
cord-345472-qrddwebe	114	36	(	(	-LRB-
cord-345472-qrddwebe	114	37	3	3	LS
cord-345472-qrddwebe	114	38	)	)	-RRB-
cord-345472-qrddwebe	114	39	the	the	DT
cord-345472-qrddwebe	114	40	molecular	molecular	JJ
cord-345472-qrddwebe	114	41	signals	signal	NNS
cord-345472-qrddwebe	114	42	that	that	WDT
cord-345472-qrddwebe	114	43	control	control	VBP
cord-345472-qrddwebe	114	44	optimal	optimal	JJ
cord-345472-qrddwebe	114	45	neutrophil	neutrophil	NN
cord-345472-qrddwebe	114	46	activation	activation	NN
cord-345472-qrddwebe	114	47	and	and	CC
cord-345472-qrddwebe	114	48	function	function	NN
cord-345472-qrddwebe	114	49	,	,	,
cord-345472-qrddwebe	114	50	and	and	CC
cord-345472-qrddwebe	114	51	(	(	-LRB-
cord-345472-qrddwebe	114	52	4	4	LS
cord-345472-qrddwebe	114	53	)	)	-RRB-
cord-345472-qrddwebe	114	54	whether	whether	IN
cord-345472-qrddwebe	114	55	specific	specific	JJ
cord-345472-qrddwebe	114	56	neutrophil	neutrophil	NN
cord-345472-qrddwebe	114	57	subtypes	subtype	NNS
cord-345472-qrddwebe	114	58	can	can	MD
cord-345472-qrddwebe	114	59	be	be	VB
cord-345472-qrddwebe	114	60	targeted	target	VBN
cord-345472-qrddwebe	114	61	therapeutically	therapeutically	RB
cord-345472-qrddwebe	114	62	to	to	TO
cord-345472-qrddwebe	114	63	improve	improve	VB
cord-345472-qrddwebe	114	64	the	the	DT
cord-345472-qrddwebe	114	65	management	management	NN
cord-345472-qrddwebe	114	66	of	of	IN
cord-345472-qrddwebe	114	67	severe	severe	JJ
cord-345472-qrddwebe	114	68	RSV	RSV	NNP
cord-345472-qrddwebe	114	69	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	114	70	.	.	.
cord-345472-qrddwebe	115	1	We	-PRON-	PRP
cord-345472-qrddwebe	115	2	discuss	discuss	VBP
cord-345472-qrddwebe	115	3	these	these	DT
cord-345472-qrddwebe	115	4	questions	question	NNS
cord-345472-qrddwebe	115	5	in	in	IN
cord-345472-qrddwebe	115	6	the	the	DT
cord-345472-qrddwebe	115	7	sections	section	NNS
cord-345472-qrddwebe	115	8	below	below	RB
cord-345472-qrddwebe	115	9	.	.	.
cord-345472-qrddwebe	116	1	The	the	DT
cord-345472-qrddwebe	116	2	earliest	early	JJS
cord-345472-qrddwebe	116	3	stages	stage	NNS
cord-345472-qrddwebe	116	4	of	of	IN
cord-345472-qrddwebe	116	5	neutrophil	neutrophil	NN
cord-345472-qrddwebe	116	6	recruitment	recruitment	NN
cord-345472-qrddwebe	116	7	are	be	VBP
cord-345472-qrddwebe	116	8	initiated	initiate	VBN
cord-345472-qrddwebe	116	9	by	by	IN
cord-345472-qrddwebe	116	10	DAMPs	damp	NNS
cord-345472-qrddwebe	116	11	(	(	-LRB-
cord-345472-qrddwebe	116	12	Table	table	NN
cord-345472-qrddwebe	116	13	2	2	CD
cord-345472-qrddwebe	116	14	)	)	-RRB-
cord-345472-qrddwebe	116	15	,	,	,
cord-345472-qrddwebe	116	16	including	include	VBG
cord-345472-qrddwebe	116	17	HMGB1	HMGB1	NNP
cord-345472-qrddwebe	116	18	,	,	,
cord-345472-qrddwebe	116	19	DNA	DNA	NNP
cord-345472-qrddwebe	116	20	,	,	,
cord-345472-qrddwebe	116	21	and	and	CC
cord-345472-qrddwebe	116	22	histones	histone	NNS
cord-345472-qrddwebe	116	23	,	,	,
cord-345472-qrddwebe	116	24	which	which	WDT
cord-345472-qrddwebe	116	25	are	be	VBP
cord-345472-qrddwebe	116	26	released	release	VBN
cord-345472-qrddwebe	116	27	by	by	IN
cord-345472-qrddwebe	116	28	damaged	damage	VBN
cord-345472-qrddwebe	116	29	or	or	CC
cord-345472-qrddwebe	116	30	dying	die	VBG
cord-345472-qrddwebe	116	31	cells	cell	NNS
cord-345472-qrddwebe	116	32	[	[	-LRB-
cord-345472-qrddwebe	116	33	75	75	CD
cord-345472-qrddwebe	116	34	]	]	-RRB-
cord-345472-qrddwebe	116	35	.	.	.
cord-345472-qrddwebe	117	1	Indeed	indeed	RB
cord-345472-qrddwebe	117	2	,	,	,
cord-345472-qrddwebe	117	3	HMGB1	HMGB1	NNP
cord-345472-qrddwebe	117	4	is	be	VBZ
cord-345472-qrddwebe	117	5	elevated	elevate	VBN
cord-345472-qrddwebe	117	6	in	in	IN
cord-345472-qrddwebe	117	7	the	the	DT
cord-345472-qrddwebe	117	8	nasopharynx	nasopharynx	NN
cord-345472-qrddwebe	117	9	of	of	IN
cord-345472-qrddwebe	117	10	RSV	RSV	NNP
cord-345472-qrddwebe	117	11	-	-	HYPH
cord-345472-qrddwebe	117	12	infected	infect	VBN
cord-345472-qrddwebe	117	13	children	child	NNS
cord-345472-qrddwebe	117	14	compared	compare	VBN
cord-345472-qrddwebe	117	15	with	with	IN
cord-345472-qrddwebe	117	16	those	those	DT
cord-345472-qrddwebe	117	17	infected	infect	VBN
cord-345472-qrddwebe	117	18	with	with	IN
cord-345472-qrddwebe	117	19	other	other	JJ
cord-345472-qrddwebe	117	20	viruses	virus	NNS
cord-345472-qrddwebe	117	21	[	[	-LRB-
cord-345472-qrddwebe	117	22	76	76	CD
cord-345472-qrddwebe	117	23	]	]	-RRB-
cord-345472-qrddwebe	117	24	.	.	.
cord-345472-qrddwebe	118	1	Animal	animal	NN
cord-345472-qrddwebe	118	2	models	model	NNS
cord-345472-qrddwebe	118	3	of	of	IN
cord-345472-qrddwebe	118	4	RSV	RSV	NNP
cord-345472-qrddwebe	118	5	-	-	HYPH
cord-345472-qrddwebe	118	6	bronchiolitis	bronchiolitis	NNP
cord-345472-qrddwebe	118	7	have	have	VBP
cord-345472-qrddwebe	118	8	improved	improve	VBN
cord-345472-qrddwebe	118	9	our	-PRON-	PRP$
cord-345472-qrddwebe	118	10	knowledge	knowledge	NN
cord-345472-qrddwebe	118	11	on	on	IN
cord-345472-qrddwebe	118	12	the	the	DT
cord-345472-qrddwebe	118	13	mechanisms	mechanism	NNS
cord-345472-qrddwebe	118	14	of	of	IN
cord-345472-qrddwebe	118	15	disease	disease	NN
cord-345472-qrddwebe	118	16	development	development	NN
cord-345472-qrddwebe	118	17	and	and	CC
cord-345472-qrddwebe	118	18	progression	progression	NN
cord-345472-qrddwebe	118	19	(	(	-LRB-
cord-345472-qrddwebe	118	20	reviewed	review	VBN
cord-345472-qrddwebe	118	21	extensively	extensively	RB
cord-345472-qrddwebe	118	22	in	in	IN
cord-345472-qrddwebe	118	23	[	[	-LRB-
cord-345472-qrddwebe	118	24	77	77	CD
cord-345472-qrddwebe	118	25	]	]	-RRB-
cord-345472-qrddwebe	118	26	[	[	-LRB-
cord-345472-qrddwebe	118	27	78	78	CD
cord-345472-qrddwebe	118	28	]	]	-RRB-
cord-345472-qrddwebe	118	29	[	[	-LRB-
cord-345472-qrddwebe	118	30	79	79	CD
cord-345472-qrddwebe	118	31	]	]	-RRB-
cord-345472-qrddwebe	118	32	)	)	-RRB-
cord-345472-qrddwebe	118	33	;	;	:
cord-345472-qrddwebe	118	34	however	however	RB
cord-345472-qrddwebe	118	35	,	,	,
cord-345472-qrddwebe	118	36	as	as	IN
cord-345472-qrddwebe	118	37	pneumoviruses	pneumoviruse	NNS
cord-345472-qrddwebe	118	38	are	be	VBP
cord-345472-qrddwebe	118	39	host	host	NN
cord-345472-qrddwebe	118	40	-	-	HYPH
cord-345472-qrddwebe	118	41	specific	specific	JJ
cord-345472-qrddwebe	118	42	,	,	,
cord-345472-qrddwebe	118	43	a	a	DT
cord-345472-qrddwebe	118	44	major	major	JJ
cord-345472-qrddwebe	118	45	limitation	limitation	NN
cord-345472-qrddwebe	118	46	with	with	IN
cord-345472-qrddwebe	118	47	using	use	VBG
cord-345472-qrddwebe	118	48	mice	mouse	NNS
cord-345472-qrddwebe	118	49	to	to	TO
cord-345472-qrddwebe	118	50	study	study	VB
cord-345472-qrddwebe	118	51	human	human	JJ
cord-345472-qrddwebe	118	52	RSV	RSV	NNP
cord-345472-qrddwebe	118	53	stems	stem	VBZ
cord-345472-qrddwebe	118	54	from	from	IN
cord-345472-qrddwebe	118	55	its	-PRON-	PRP$
cord-345472-qrddwebe	118	56	inability	inability	NN
cord-345472-qrddwebe	118	57	to	to	TO
cord-345472-qrddwebe	118	58	replicate	replicate	VB
cord-345472-qrddwebe	118	59	efficiently	efficiently	RB
cord-345472-qrddwebe	118	60	in	in	IN
cord-345472-qrddwebe	118	61	this	this	DT
cord-345472-qrddwebe	118	62	setting	setting	NN
cord-345472-qrddwebe	118	63	.	.	.
cord-345472-qrddwebe	119	1	To	to	TO
cord-345472-qrddwebe	119	2	better	well	RBR
cord-345472-qrddwebe	119	3	understand	understand	VB
cord-345472-qrddwebe	119	4	the	the	DT
cord-345472-qrddwebe	119	5	pathogenic	pathogenic	JJ
cord-345472-qrddwebe	119	6	processes	process	NNS
cord-345472-qrddwebe	119	7	that	that	WDT
cord-345472-qrddwebe	119	8	underlie	underlie	VBP
cord-345472-qrddwebe	119	9	viral	viral	JJ
cord-345472-qrddwebe	119	10	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	119	11	,	,	,
cord-345472-qrddwebe	119	12	we	-PRON-	PRP
cord-345472-qrddwebe	119	13	and	and	CC
cord-345472-qrddwebe	119	14	others	other	NNS
cord-345472-qrddwebe	119	15	have	have	VBP
cord-345472-qrddwebe	119	16	preferred	prefer	VBN
cord-345472-qrddwebe	119	17	to	to	TO
cord-345472-qrddwebe	119	18	inoculate	inoculate	VB
cord-345472-qrddwebe	119	19	mice	mouse	NNS
cord-345472-qrddwebe	119	20	with	with	IN
cord-345472-qrddwebe	119	21	pneumonia	pneumonia	NN
cord-345472-qrddwebe	119	22	virus	virus	NN
cord-345472-qrddwebe	119	23	of	of	IN
cord-345472-qrddwebe	119	24	mice	mouse	NNS
cord-345472-qrddwebe	119	25	(	(	-LRB-
cord-345472-qrddwebe	119	26	PVM	PVM	NNP
cord-345472-qrddwebe	119	27	)	)	-RRB-
cord-345472-qrddwebe	119	28	,	,	,
cord-345472-qrddwebe	119	29	which	which	WDT
cord-345472-qrddwebe	119	30	is	be	VBZ
cord-345472-qrddwebe	119	31	orthologous	orthologous	JJ
cord-345472-qrddwebe	119	32	to	to	IN
cord-345472-qrddwebe	119	33	human	human	JJ
cord-345472-qrddwebe	119	34	RSV	RSV	NNP
cord-345472-qrddwebe	119	35	[	[	-LRB-
cord-345472-qrddwebe	119	36	9	9	CD
cord-345472-qrddwebe	119	37	,	,	,
cord-345472-qrddwebe	119	38	80	80	CD
cord-345472-qrddwebe	119	39	]	]	-RRB-
cord-345472-qrddwebe	119	40	.	.	.
cord-345472-qrddwebe	120	1	Because	because	IN
cord-345472-qrddwebe	120	2	PVM	PVM	NNP
cord-345472-qrddwebe	120	3	is	be	VBZ
cord-345472-qrddwebe	120	4	a	a	DT
cord-345472-qrddwebe	120	5	natural	natural	JJ
cord-345472-qrddwebe	120	6	pathogen	pathogen	NN
cord-345472-qrddwebe	120	7	in	in	IN
cord-345472-qrddwebe	120	8	rodents	rodent	NNS
cord-345472-qrddwebe	120	9	,	,	,
cord-345472-qrddwebe	120	10	a	a	DT
cord-345472-qrddwebe	120	11	low	low	JJ
cord-345472-qrddwebe	120	12	inoculum	inoculum	NN
cord-345472-qrddwebe	120	13	dose	dose	NN
cord-345472-qrddwebe	120	14	(	(	-LRB-
cord-345472-qrddwebe	120	15	e.g.	e.g.	RB
cord-345472-qrddwebe	120	16	,	,	,
cord-345472-qrddwebe	120	17	10	10	CD
cord-345472-qrddwebe	120	18	PFU	pfu	NN
cord-345472-qrddwebe	120	19	)	)	-RRB-
cord-345472-qrddwebe	120	20	can	can	MD
cord-345472-qrddwebe	120	21	be	be	VB
cord-345472-qrddwebe	120	22	employed	employ	VBN
cord-345472-qrddwebe	120	23	,	,	,
cord-345472-qrddwebe	120	24	and	and	CC
cord-345472-qrddwebe	120	25	this	this	DT
cord-345472-qrddwebe	120	26	allows	allow	VBZ
cord-345472-qrddwebe	120	27	for	for	IN
cord-345472-qrddwebe	120	28	greater	great	JJR
cord-345472-qrddwebe	120	29	insights	insight	NNS
cord-345472-qrddwebe	120	30	into	into	IN
cord-345472-qrddwebe	120	31	host	host	NN
cord-345472-qrddwebe	120	32	-	-	HYPH
cord-345472-qrddwebe	120	33	pathogen	pathogen	NN
cord-345472-qrddwebe	120	34	interactions	interaction	NNS
cord-345472-qrddwebe	120	35	over	over	IN
cord-345472-qrddwebe	120	36	time	time	NN
cord-345472-qrddwebe	120	37	as	as	IN
cord-345472-qrddwebe	120	38	the	the	DT
cord-345472-qrddwebe	120	39	virus	virus	NN
cord-345472-qrddwebe	120	40	replicates	replicate	VBZ
cord-345472-qrddwebe	120	41	in	in	IN
cord-345472-qrddwebe	120	42	the	the	DT
cord-345472-qrddwebe	120	43	airway	airway	NN
cord-345472-qrddwebe	120	44	epithelium	epithelium	NN
cord-345472-qrddwebe	120	45	.	.	.
cord-345472-qrddwebe	121	1	Importantly	importantly	RB
cord-345472-qrddwebe	121	2	,	,	,
cord-345472-qrddwebe	121	3	inoculation	inoculation	NN
cord-345472-qrddwebe	121	4	with	with	IN
cord-345472-qrddwebe	121	5	a	a	DT
cord-345472-qrddwebe	121	6	low	low	JJ
cord-345472-qrddwebe	121	7	dose	dose	NN
cord-345472-qrddwebe	121	8	of	of	IN
cord-345472-qrddwebe	121	9	PVM	PVM	NNP
cord-345472-qrddwebe	121	10	can	can	MD
cord-345472-qrddwebe	121	11	induce	induce	VB
cord-345472-qrddwebe	121	12	the	the	DT
cord-345472-qrddwebe	121	13	more	more	RBR
cord-345472-qrddwebe	121	14	severe	severe	JJ
cord-345472-qrddwebe	121	15	pathologies	pathology	NNS
cord-345472-qrddwebe	121	16	of	of	IN
cord-345472-qrddwebe	121	17	infant	infant	NN
cord-345472-qrddwebe	121	18	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	121	19	,	,	,
cord-345472-qrddwebe	121	20	such	such	JJ
cord-345472-qrddwebe	121	21	as	as	IN
cord-345472-qrddwebe	121	22	alveolar	alveolar	JJ
cord-345472-qrddwebe	121	23	epithelial	epithelial	JJ
cord-345472-qrddwebe	121	24	cell	cell	NN
cord-345472-qrddwebe	121	25	apoptosis	apoptosis	NN
cord-345472-qrddwebe	121	26	,	,	,
cord-345472-qrddwebe	121	27	bronchial	bronchial	JJ
cord-345472-qrddwebe	121	28	epithelial	epithelial	JJ
cord-345472-qrddwebe	121	29	necrosis	necrosis	NN
cord-345472-qrddwebe	121	30	,	,	,
cord-345472-qrddwebe	121	31	multifocal	multifocal	JJ
cord-345472-qrddwebe	121	32	acute	acute	JJ
cord-345472-qrddwebe	121	33	alveolitis	alveolitis	NN
cord-345472-qrddwebe	121	34	,	,	,
cord-345472-qrddwebe	121	35	intra	intra	JJ
cord-345472-qrddwebe	121	36	-	-	JJ
cord-345472-qrddwebe	121	37	alveolar	alveolar	JJ
cord-345472-qrddwebe	121	38	oedema	oedema	NN
cord-345472-qrddwebe	121	39	,	,	,
cord-345472-qrddwebe	121	40	haemorrhage	haemorrhage	NN
cord-345472-qrddwebe	121	41	,	,	,
cord-345472-qrddwebe	121	42	and	and	CC
cord-345472-qrddwebe	121	43	increased	increase	VBD
cord-345472-qrddwebe	121	44	neutrophilia	neutrophilia	NNP
cord-345472-qrddwebe	121	45	[	[	-LRB-
cord-345472-qrddwebe	121	46	76	76	CD
cord-345472-qrddwebe	121	47	,	,	,
cord-345472-qrddwebe	121	48	78	78	CD
cord-345472-qrddwebe	121	49	,	,	,
cord-345472-qrddwebe	121	50	81	81	CD
cord-345472-qrddwebe	121	51	]	]	-RRB-
cord-345472-qrddwebe	121	52	.	.	.
cord-345472-qrddwebe	122	1	These	these	DT
cord-345472-qrddwebe	122	2	pathological	pathological	JJ
cord-345472-qrddwebe	122	3	features	feature	NNS
cord-345472-qrddwebe	122	4	are	be	VBP
cord-345472-qrddwebe	122	5	similar	similar	JJ
cord-345472-qrddwebe	122	6	to	to	IN
cord-345472-qrddwebe	122	7	those	those	DT
cord-345472-qrddwebe	122	8	observed	observe	VBN
cord-345472-qrddwebe	122	9	in	in	IN
cord-345472-qrddwebe	122	10	autopsy	autopsy	JJ
cord-345472-qrddwebe	122	11	samples	sample	NNS
cord-345472-qrddwebe	122	12	obtained	obtain	VBN
cord-345472-qrddwebe	122	13	from	from	IN
cord-345472-qrddwebe	122	14	fatal	fatal	JJ
cord-345472-qrddwebe	122	15	cases	case	NNS
cord-345472-qrddwebe	122	16	of	of	IN
cord-345472-qrddwebe	122	17	RSV	RSV	NNP
cord-345472-qrddwebe	122	18	bronchiolitis	bronchiolitis	NNP
cord-345472-qrddwebe	122	19	[	[	-LRB-
cord-345472-qrddwebe	122	20	9	9	CD
cord-345472-qrddwebe	122	21	]	]	-RRB-
cord-345472-qrddwebe	122	22	.	.	.
cord-345472-qrddwebe	123	1	Although	although	IN
cord-345472-qrddwebe	123	2	there	there	EX
cord-345472-qrddwebe	123	3	are	be	VBP
cord-345472-qrddwebe	123	4	limitations	limitation	NNS
cord-345472-qrddwebe	123	5	with	with	IN
cord-345472-qrddwebe	123	6	the	the	DT
cord-345472-qrddwebe	123	7	use	use	NN
cord-345472-qrddwebe	123	8	of	of	IN
cord-345472-qrddwebe	123	9	PVM	PVM	NNP
cord-345472-qrddwebe	123	10	(	(	-LRB-
cord-345472-qrddwebe	123	11	highlighted	highlight	VBN
cord-345472-qrddwebe	123	12	in	in	IN
cord-345472-qrddwebe	123	13	[	[	-LRB-
cord-345472-qrddwebe	123	14	78	78	CD
cord-345472-qrddwebe	123	15	]	]	-RRB-
cord-345472-qrddwebe	123	16	)	)	-RRB-
cord-345472-qrddwebe	123	17	,	,	,
cord-345472-qrddwebe	123	18	it	-PRON-	PRP
cord-345472-qrddwebe	123	19	is	be	VBZ
cord-345472-qrddwebe	123	20	proving	prove	VBG
cord-345472-qrddwebe	123	21	a	a	DT
cord-345472-qrddwebe	123	22	useful	useful	JJ
cord-345472-qrddwebe	123	23	model	model	NN
cord-345472-qrddwebe	123	24	to	to	TO
cord-345472-qrddwebe	123	25	understand	understand	VB
cord-345472-qrddwebe	123	26	the	the	DT
cord-345472-qrddwebe	123	27	cellular	cellular	JJ
cord-345472-qrddwebe	123	28	and	and	CC
cord-345472-qrddwebe	123	29	molecular	molecular	JJ
cord-345472-qrddwebe	123	30	processes	process	NNS
cord-345472-qrddwebe	123	31	that	that	WDT
cord-345472-qrddwebe	123	32	underlie	underlie	VBP
cord-345472-qrddwebe	123	33	pathogenesis	pathogenesis	NN
cord-345472-qrddwebe	123	34	.	.	.
cord-345472-qrddwebe	124	1	Unlike	unlike	IN
cord-345472-qrddwebe	124	2	wild	wild	JJ
cord-345472-qrddwebe	124	3	-	-	HYPH
cord-345472-qrddwebe	124	4	type	type	NN
cord-345472-qrddwebe	124	5	(	(	-LRB-
cord-345472-qrddwebe	124	6	WT	WT	NNP
cord-345472-qrddwebe	124	7	)	)	-RRB-
cord-345472-qrddwebe	124	8	control	control	NN
cord-345472-qrddwebe	124	9	mice	mouse	NNS
cord-345472-qrddwebe	124	10	,	,	,
cord-345472-qrddwebe	124	11	plasmacytoid	plasmacytoid	NNP
cord-345472-qrddwebe	124	12	dendritic	dendritic	JJ
cord-345472-qrddwebe	124	13	cell	cell	NN
cord-345472-qrddwebe	124	14	(	(	-LRB-
cord-345472-qrddwebe	124	15	pDC)-depleted	pdc)-deplete	VBN
cord-345472-qrddwebe	124	16	,	,	,
cord-345472-qrddwebe	124	17	Toll	toll	NN
cord-345472-qrddwebe	124	18	-	-	HYPH
cord-345472-qrddwebe	124	19	like	like	JJ
cord-345472-qrddwebe	124	20	receptor	receptor	NN
cord-345472-qrddwebe	124	21	(	(	-LRB-
cord-345472-qrddwebe	124	22	TLR)7-deficient	tlr)7-deficient	NN
cord-345472-qrddwebe	124	23	,	,	,
cord-345472-qrddwebe	124	24	or	or	CC
cord-345472-qrddwebe	124	25	interferon	interferon	NN
cord-345472-qrddwebe	124	26	regulatory	regulatory	JJ
cord-345472-qrddwebe	124	27	factor	factor	NN
cord-345472-qrddwebe	124	28	(	(	-LRB-
cord-345472-qrddwebe	124	29	IRF)7-deficient	irf)7-deficient	JJ
cord-345472-qrddwebe	124	30	neonatal	neonatal	JJ
cord-345472-qrddwebe	124	31	mice	mouse	NNS
cord-345472-qrddwebe	124	32	develop	develop	VBP
cord-345472-qrddwebe	124	33	severe	severe	JJ
cord-345472-qrddwebe	124	34	pathology	pathology	NN
cord-345472-qrddwebe	124	35	,	,	,
cord-345472-qrddwebe	124	36	characterised	characterise	VBN
cord-345472-qrddwebe	124	37	by	by	IN
cord-345472-qrddwebe	124	38	increased	increase	VBN
cord-345472-qrddwebe	124	39	neutrophilia	neutrophilia	NNP
cord-345472-qrddwebe	124	40	and	and	CC
cord-345472-qrddwebe	124	41	lung	lung	NN
cord-345472-qrddwebe	124	42	inflammation	inflammation	NN
cord-345472-qrddwebe	124	43	in	in	IN
cord-345472-qrddwebe	124	44	response	response	NN
cord-345472-qrddwebe	124	45	to	to	IN
cord-345472-qrddwebe	124	46	acute	acute	JJ
cord-345472-qrddwebe	124	47	PVM	pvm	NN
cord-345472-qrddwebe	124	48	infection	infection	NN
cord-345472-qrddwebe	124	49	[	[	-LRB-
cord-345472-qrddwebe	124	50	80	80	CD
cord-345472-qrddwebe	124	51	]	]	-RRB-
cord-345472-qrddwebe	124	52	[	[	-LRB-
cord-345472-qrddwebe	124	53	81	81	CD
cord-345472-qrddwebe	124	54	]	]	-RRB-
cord-345472-qrddwebe	124	55	[	[	-LRB-
cord-345472-qrddwebe	124	56	82	82	CD
cord-345472-qrddwebe	124	57	]	]	-RRB-
cord-345472-qrddwebe	124	58	.	.	.
cord-345472-qrddwebe	125	1	In	in	IN
cord-345472-qrddwebe	125	2	the	the	DT
cord-345472-qrddwebe	125	3	absence	absence	NN
cord-345472-qrddwebe	125	4	of	of	IN
cord-345472-qrddwebe	125	5	the	the	DT
cord-345472-qrddwebe	125	6	TLR7-IRF7	TLR7-IRF7	NNP
cord-345472-qrddwebe	125	7	signalling	signal	VBG
cord-345472-qrddwebe	125	8	pathway	pathway	NN
cord-345472-qrddwebe	125	9	,	,	,
cord-345472-qrddwebe	125	10	massive	massive	JJ
cord-345472-qrddwebe	125	11	amounts	amount	NNS
cord-345472-qrddwebe	125	12	of	of	IN
cord-345472-qrddwebe	125	13	preformed	preformed	JJ
cord-345472-qrddwebe	125	14	airway	airway	NN
cord-345472-qrddwebe	125	15	epithelial	epithelial	JJ
cord-345472-qrddwebe	125	16	cell	cell	NN
cord-345472-qrddwebe	125	17	HMGB1	HMGB1	NNP
cord-345472-qrddwebe	125	18	is	be	VBZ
cord-345472-qrddwebe	125	19	released	release	VBN
cord-345472-qrddwebe	125	20	into	into	IN
cord-345472-qrddwebe	125	21	the	the	DT
cord-345472-qrddwebe	125	22	extracellular	extracellular	JJ
cord-345472-qrddwebe	125	23	environment	environment	NN
cord-345472-qrddwebe	125	24	,	,	,
cord-345472-qrddwebe	125	25	increasing	increase	VBG
cord-345472-qrddwebe	125	26	the	the	DT
cord-345472-qrddwebe	125	27	level	level	NN
cord-345472-qrddwebe	125	28	of	of	IN
cord-345472-qrddwebe	125	29	neutrophilic	neutrophilic	JJ
cord-345472-qrddwebe	125	30	inflammation	inflammation	NN
cord-345472-qrddwebe	125	31	and	and	CC
cord-345472-qrddwebe	125	32	amplifying	amplify	VBG
cord-345472-qrddwebe	125	33	tissue	tissue	NN
cord-345472-qrddwebe	125	34	pathology	pathology	NN
cord-345472-qrddwebe	125	35	,	,	,
cord-345472-qrddwebe	125	36	most	most	RBS
cord-345472-qrddwebe	125	37	notably	notably	RB
cord-345472-qrddwebe	125	38	tissue	tissue	NN
cord-345472-qrddwebe	125	39	oedema	oedema	NN
cord-345472-qrddwebe	125	40	,	,	,
cord-345472-qrddwebe	125	41	epithelial	epithelial	JJ
cord-345472-qrddwebe	125	42	sloughing	sloughing	NN
cord-345472-qrddwebe	125	43	,	,	,
cord-345472-qrddwebe	125	44	and	and	CC
cord-345472-qrddwebe	125	45	cell	cell	NN
cord-345472-qrddwebe	125	46	death	death	NN
cord-345472-qrddwebe	125	47	[	[	-LRB-
cord-345472-qrddwebe	125	48	76	76	CD
cord-345472-qrddwebe	125	49	,	,	,
cord-345472-qrddwebe	125	50	80	80	CD
cord-345472-qrddwebe	125	51	,	,	,
cord-345472-qrddwebe	125	52	82	82	CD
cord-345472-qrddwebe	125	53	,	,	,
cord-345472-qrddwebe	125	54	83	83	CD
cord-345472-qrddwebe	125	55	]	]	-RRB-
cord-345472-qrddwebe	125	56	.	.	.
cord-345472-qrddwebe	126	1	The	the	DT
cord-345472-qrddwebe	126	2	cell	cell	NN
cord-345472-qrddwebe	126	3	death	death	NN
cord-345472-qrddwebe	126	4	occurs	occur	VBZ
cord-345472-qrddwebe	126	5	through	through	IN
cord-345472-qrddwebe	126	6	programmed	program	VBN
cord-345472-qrddwebe	126	7	necroptosis	necroptosis	NN
cord-345472-qrddwebe	126	8	and	and	CC
cord-345472-qrddwebe	126	9	further	further	JJ
cord-345472-qrddwebe	126	10	increases	increase	VBZ
cord-345472-qrddwebe	126	11	the	the	DT
cord-345472-qrddwebe	126	12	levels	level	NNS
cord-345472-qrddwebe	126	13	of	of	IN
cord-345472-qrddwebe	126	14	HMGB1	HMGB1	NNP
cord-345472-qrddwebe	126	15	,	,	,
cord-345472-qrddwebe	126	16	perpetuating	perpetuate	VBG
cord-345472-qrddwebe	126	17	the	the	DT
cord-345472-qrddwebe	126	18	inflammatory	inflammatory	JJ
cord-345472-qrddwebe	126	19	response	response	NN
cord-345472-qrddwebe	126	20	[	[	-LRB-
cord-345472-qrddwebe	126	21	76	76	CD
cord-345472-qrddwebe	126	22	]	]	-RRB-
cord-345472-qrddwebe	126	23	.	.	.
cord-345472-qrddwebe	127	1	RSV	RSV	NNP
cord-345472-qrddwebe	127	2	infection	infection	NN
cord-345472-qrddwebe	127	3	of	of	IN
cord-345472-qrddwebe	127	4	primary	primary	JJ
cord-345472-qrddwebe	127	5	human	human	JJ
cord-345472-qrddwebe	127	6	airway	airway	NN
cord-345472-qrddwebe	127	7	epithelial	epithelial	JJ
cord-345472-qrddwebe	127	8	cells	cell	NNS
cord-345472-qrddwebe	127	9	also	also	RB
cord-345472-qrddwebe	127	10	induces	induce	VBZ
cord-345472-qrddwebe	127	11	necroptosis	necroptosis	NN
cord-345472-qrddwebe	127	12	-	-	HYPH
cord-345472-qrddwebe	127	13	dependent	dependent	JJ
cord-345472-qrddwebe	127	14	HMGB1	HMGB1	NNP
cord-345472-qrddwebe	127	15	release	release	NN
cord-345472-qrddwebe	127	16	[	[	-LRB-
cord-345472-qrddwebe	127	17	76	76	CD
cord-345472-qrddwebe	127	18	]	]	-RRB-
cord-345472-qrddwebe	127	19	.	.	.
cord-345472-qrddwebe	128	1	Intriguingly	intriguingly	RB
cord-345472-qrddwebe	128	2	,	,	,
cord-345472-qrddwebe	128	3	therapeutic	therapeutic	JJ
cord-345472-qrddwebe	128	4	inhibition	inhibition	NN
cord-345472-qrddwebe	128	5	of	of	IN
cord-345472-qrddwebe	128	6	necroptosis	necroptosis	NN
cord-345472-qrddwebe	128	7	during	during	IN
cord-345472-qrddwebe	128	8	severe	severe	JJ
cord-345472-qrddwebe	128	9	viral	viral	JJ
cord-345472-qrddwebe	128	10	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	128	11	protected	protect	VBD
cord-345472-qrddwebe	128	12	mice	mouse	NNS
cord-345472-qrddwebe	128	13	against	against	IN
cord-345472-qrddwebe	128	14	the	the	DT
cord-345472-qrddwebe	128	15	subsequent	subsequent	JJ
cord-345472-qrddwebe	128	16	development	development	NN
cord-345472-qrddwebe	128	17	of	of	IN
cord-345472-qrddwebe	128	18	experimental	experimental	JJ
cord-345472-qrddwebe	128	19	asthma	asthma	NN
cord-345472-qrddwebe	128	20	in	in	IN
cord-345472-qrddwebe	128	21	later	later	JJ
cord-345472-qrddwebe	128	22	-	-	HYPH
cord-345472-qrddwebe	128	23	life	life	NN
cord-345472-qrddwebe	128	24	[	[	-LRB-
cord-345472-qrddwebe	128	25	76	76	CD
cord-345472-qrddwebe	128	26	]	]	-RRB-
cord-345472-qrddwebe	128	27	,	,	,
cord-345472-qrddwebe	128	28	indicating	indicate	VBG
cord-345472-qrddwebe	128	29	that	that	IN
cord-345472-qrddwebe	128	30	severe	severe	JJ
cord-345472-qrddwebe	128	31	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	128	32	is	be	VBZ
cord-345472-qrddwebe	128	33	causally	causally	RB
cord-345472-qrddwebe	128	34	associated	associate	VBN
cord-345472-qrddwebe	128	35	with	with	IN
cord-345472-qrddwebe	128	36	subsequent	subsequent	JJ
cord-345472-qrddwebe	128	37	asthma	asthma	NN
cord-345472-qrddwebe	128	38	.	.	.
cord-345472-qrddwebe	129	1	Examination	examination	NN
cord-345472-qrddwebe	129	2	of	of	IN
cord-345472-qrddwebe	129	3	the	the	DT
cord-345472-qrddwebe	129	4	infant	infant	NN
cord-345472-qrddwebe	129	5	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	129	6	revealed	reveal	VBD
cord-345472-qrddwebe	129	7	that	that	IN
cord-345472-qrddwebe	129	8	pharmacological	pharmacological	JJ
cord-345472-qrddwebe	129	9	inhibition	inhibition	NN
cord-345472-qrddwebe	129	10	of	of	IN
cord-345472-qrddwebe	129	11	necroptosis	necroptosis	NNP
cord-345472-qrddwebe	129	12	or	or	CC
cord-345472-qrddwebe	129	13	immunoneutralisation	immunoneutralisation	NN
cord-345472-qrddwebe	129	14	of	of	IN
cord-345472-qrddwebe	129	15	HMGB1	HMGB1	NNP
cord-345472-qrddwebe	129	16	decreases	decrease	VBZ
cord-345472-qrddwebe	129	17	the	the	DT
cord-345472-qrddwebe	129	18	expansion	expansion	NN
cord-345472-qrddwebe	129	19	of	of	IN
cord-345472-qrddwebe	129	20	IL-13-producing	il-13-produce	VBG
cord-345472-qrddwebe	129	21	type-2	type-2	NN
cord-345472-qrddwebe	129	22	innate	innate	JJ
cord-345472-qrddwebe	129	23	lymphoid	lymphoid	JJ
cord-345472-qrddwebe	129	24	cells	cell	NNS
cord-345472-qrddwebe	129	25	(	(	-LRB-
cord-345472-qrddwebe	129	26	ILC2s	ILC2s	NNP
cord-345472-qrddwebe	129	27	)	)	-RRB-
cord-345472-qrddwebe	129	28	,	,	,
cord-345472-qrddwebe	129	29	and	and	CC
cord-345472-qrddwebe	129	30	prevents	prevent	VBZ
cord-345472-qrddwebe	129	31	alterations	alteration	NNS
cord-345472-qrddwebe	129	32	to	to	IN
cord-345472-qrddwebe	129	33	the	the	DT
cord-345472-qrddwebe	129	34	airway	airway	NN
cord-345472-qrddwebe	129	35	wall	wall	NN
cord-345472-qrddwebe	129	36	such	such	JJ
cord-345472-qrddwebe	129	37	as	as	IN
cord-345472-qrddwebe	129	38	thickening	thickening	NN
cord-345472-qrddwebe	129	39	of	of	IN
cord-345472-qrddwebe	129	40	the	the	DT
cord-345472-qrddwebe	129	41	airway	airway	NN
cord-345472-qrddwebe	129	42	smooth	smooth	JJ
cord-345472-qrddwebe	129	43	muscle	muscle	NN
cord-345472-qrddwebe	129	44	(	(	-LRB-
cord-345472-qrddwebe	129	45	ASM	ASM	NNP
cord-345472-qrddwebe	129	46	)	)	-RRB-
cord-345472-qrddwebe	129	47	layer	layer	NN
cord-345472-qrddwebe	129	48	[	[	-LRB-
cord-345472-qrddwebe	129	49	76	76	CD
cord-345472-qrddwebe	129	50	,	,	,
cord-345472-qrddwebe	129	51	83	83	CD
cord-345472-qrddwebe	129	52	]	]	-RRB-
cord-345472-qrddwebe	129	53	.	.	.
cord-345472-qrddwebe	130	1	In	in	IN
cord-345472-qrddwebe	130	2	vitro	vitro	FW
cord-345472-qrddwebe	130	3	,	,	,
cord-345472-qrddwebe	130	4	ASM	ASM	NNP
cord-345472-qrddwebe	130	5	cells	cell	NNS
cord-345472-qrddwebe	130	6	cultured	culture	VBN
cord-345472-qrddwebe	130	7	with	with	IN
cord-345472-qrddwebe	130	8	IL-33	IL-33	NNP
cord-345472-qrddwebe	131	1	/IL-2-activated	/IL-2-activated	.
cord-345472-qrddwebe	132	1	ILC2s	ILC2s	NNP
cord-345472-qrddwebe	133	1	isolated	isolate	VBN
cord-345472-qrddwebe	133	2	from	from	IN
cord-345472-qrddwebe	133	3	the	the	DT
cord-345472-qrddwebe	133	4	lungs	lung	NNS
cord-345472-qrddwebe	133	5	of	of	IN
cord-345472-qrddwebe	133	6	PVM	pvm	NN
cord-345472-qrddwebe	133	7	-	-	HYPH
cord-345472-qrddwebe	133	8	infected	infect	VBN
cord-345472-qrddwebe	133	9	mice	mouse	NNS
cord-345472-qrddwebe	133	10	undergo	undergo	VBP
cord-345472-qrddwebe	133	11	increased	increase	VBN
cord-345472-qrddwebe	133	12	cell	cell	NN
cord-345472-qrddwebe	133	13	division	division	NN
cord-345472-qrddwebe	133	14	,	,	,
cord-345472-qrddwebe	133	15	elucidating	elucidate	VBG
cord-345472-qrddwebe	133	16	a	a	DT
cord-345472-qrddwebe	133	17	cellular	cellular	JJ
cord-345472-qrddwebe	133	18	and	and	CC
cord-345472-qrddwebe	133	19	molecular	molecular	JJ
cord-345472-qrddwebe	133	20	pathway	pathway	NN
cord-345472-qrddwebe	133	21	by	by	IN
cord-345472-qrddwebe	133	22	which	which	WDT
cord-345472-qrddwebe	133	23	excessive	excessive	JJ
cord-345472-qrddwebe	133	24	inflammation	inflammation	NN
cord-345472-qrddwebe	133	25	and	and	CC
cord-345472-qrddwebe	133	26	immunopathology	immunopathology	NN
cord-345472-qrddwebe	133	27	promotes	promote	VBZ
cord-345472-qrddwebe	133	28	both	both	DT
cord-345472-qrddwebe	133	29	type	type	NN
cord-345472-qrddwebe	133	30	2	2	CD
cord-345472-qrddwebe	133	31	inflammation	inflammation	NN
cord-345472-qrddwebe	133	32	and	and	CC
cord-345472-qrddwebe	133	33	an	an	DT
cord-345472-qrddwebe	133	34	aberrant	aberrant	JJ
cord-345472-qrddwebe	133	35	repair	repair	NN
cord-345472-qrddwebe	133	36	response	response	NN
cord-345472-qrddwebe	133	37	that	that	WDT
cord-345472-qrddwebe	133	38	alters	alter	VBZ
cord-345472-qrddwebe	133	39	the	the	DT
cord-345472-qrddwebe	133	40	architecture	architecture	NN
cord-345472-qrddwebe	133	41	of	of	IN
cord-345472-qrddwebe	133	42	the	the	DT
cord-345472-qrddwebe	133	43	developing	develop	VBG
cord-345472-qrddwebe	133	44	lung	lung	NN
cord-345472-qrddwebe	133	45	[	[	-LRB-
cord-345472-qrddwebe	133	46	83	83	CD
cord-345472-qrddwebe	133	47	]	]	-RRB-
cord-345472-qrddwebe	133	48	.	.	.
cord-345472-qrddwebe	134	1	Therefore	therefore	RB
cord-345472-qrddwebe	134	2	,	,	,
cord-345472-qrddwebe	134	3	therapeutic	therapeutic	JJ
cord-345472-qrddwebe	134	4	targeting	targeting	NN
cord-345472-qrddwebe	134	5	of	of	IN
cord-345472-qrddwebe	134	6	the	the	DT
cord-345472-qrddwebe	134	7	HMGB1	HMGB1	NNP
cord-345472-qrddwebe	134	8	signalling	signal	VBG
cord-345472-qrddwebe	134	9	axis	axis	NN
cord-345472-qrddwebe	134	10	may	may	MD
cord-345472-qrddwebe	134	11	act	act	VB
cord-345472-qrddwebe	134	12	as	as	IN
cord-345472-qrddwebe	134	13	a	a	DT
cord-345472-qrddwebe	134	14	novel	novel	JJ
cord-345472-qrddwebe	134	15	asthma	asthma	NN
cord-345472-qrddwebe	134	16	preventative	preventative	NN
cord-345472-qrddwebe	134	17	by	by	IN
cord-345472-qrddwebe	134	18	dampening	dampen	VBG
cord-345472-qrddwebe	134	19	ILC2-mediated	ilc2-mediate	VBN
cord-345472-qrddwebe	134	20	type-2	type-2	NN
cord-345472-qrddwebe	134	21	inflammation	inflammation	NN
cord-345472-qrddwebe	134	22	and	and	CC
cord-345472-qrddwebe	134	23	associated	associate	VBD
cord-345472-qrddwebe	134	24	ASM	ASM	NNP
cord-345472-qrddwebe	134	25	remodelling	remodelling	NN
cord-345472-qrddwebe	134	26	.	.	.
cord-345472-qrddwebe	135	1	Low	low	JJ
cord-345472-qrddwebe	135	2	circulating	circulate	VBG
cord-345472-qrddwebe	135	3	pDC	pdc	CD
cord-345472-qrddwebe	135	4	numbers	number	NNS
cord-345472-qrddwebe	135	5	in	in	IN
cord-345472-qrddwebe	135	6	infancy	infancy	NN
cord-345472-qrddwebe	135	7	are	be	VBP
cord-345472-qrddwebe	135	8	associated	associate	VBN
cord-345472-qrddwebe	135	9	with	with	IN
cord-345472-qrddwebe	135	10	acute	acute	JJ
cord-345472-qrddwebe	135	11	LRIs	lri	NNS
cord-345472-qrddwebe	135	12	[	[	-LRB-
cord-345472-qrddwebe	135	13	84	84	CD
cord-345472-qrddwebe	135	14	]	]	-RRB-
cord-345472-qrddwebe	135	15	.	.	.
cord-345472-qrddwebe	136	1	Interestingly	interestingly	RB
cord-345472-qrddwebe	136	2	,	,	,
cord-345472-qrddwebe	136	3	the	the	DT
cord-345472-qrddwebe	136	4	temporal	temporal	JJ
cord-345472-qrddwebe	136	5	depletion	depletion	NN
cord-345472-qrddwebe	136	6	of	of	IN
cord-345472-qrddwebe	136	7	pDC	pdc	CD
cord-345472-qrddwebe	136	8	in	in	IN
cord-345472-qrddwebe	136	9	neonatal	neonatal	JJ
cord-345472-qrddwebe	136	10	mice	mouse	NNS
cord-345472-qrddwebe	136	11	predisposes	predispose	VBZ
cord-345472-qrddwebe	136	12	to	to	IN
cord-345472-qrddwebe	136	13	severe	severe	JJ
cord-345472-qrddwebe	136	14	PVM	PVM	NNP
cord-345472-qrddwebe	136	15	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	136	16	due	due	IN
cord-345472-qrddwebe	136	17	to	to	IN
cord-345472-qrddwebe	136	18	a	a	DT
cord-345472-qrddwebe	136	19	lack	lack	NN
cord-345472-qrddwebe	136	20	of	of	IN
cord-345472-qrddwebe	136	21	immunoregulation	immunoregulation	NN
cord-345472-qrddwebe	136	22	by	by	IN
cord-345472-qrddwebe	136	23	regulatory	regulatory	JJ
cord-345472-qrddwebe	136	24	T	T	NNP
cord-345472-qrddwebe	136	25	-	-	HYPH
cord-345472-qrddwebe	136	26	cells	cell	NNS
cord-345472-qrddwebe	136	27	[	[	-LRB-
cord-345472-qrddwebe	136	28	80	80	CD
cord-345472-qrddwebe	136	29	]	]	-RRB-
cord-345472-qrddwebe	136	30	.	.	.
cord-345472-qrddwebe	137	1	The	the	DT
cord-345472-qrddwebe	137	2	adoptive	adoptive	JJ
cord-345472-qrddwebe	137	3	transfer	transfer	NN
cord-345472-qrddwebe	137	4	of	of	IN
cord-345472-qrddwebe	137	5	splenic	splenic	JJ
cord-345472-qrddwebe	137	6	regulatory	regulatory	JJ
cord-345472-qrddwebe	137	7	T	t	NN
cord-345472-qrddwebe	137	8	-	-	HYPH
cord-345472-qrddwebe	137	9	cells	cell	NNS
cord-345472-qrddwebe	137	10	to	to	IN
cord-345472-qrddwebe	137	11	infected	infected	JJ
cord-345472-qrddwebe	137	12	pDC	pDC	NNP
cord-345472-qrddwebe	137	13	-	-	HYPH
cord-345472-qrddwebe	137	14	depleted	deplete	VBN
cord-345472-qrddwebe	137	15	neonatal	neonatal	JJ
cord-345472-qrddwebe	137	16	mice	mouse	NNS
cord-345472-qrddwebe	137	17	decreased	decrease	VBD
cord-345472-qrddwebe	137	18	HMGB1	HMGB1	NNP
cord-345472-qrddwebe	138	1	and	and	CC
cord-345472-qrddwebe	138	2	IL-6	IL-6	NNP
cord-345472-qrddwebe	138	3	levels	level	NNS
cord-345472-qrddwebe	138	4	,	,	,
cord-345472-qrddwebe	138	5	epithelial	epithelial	JJ
cord-345472-qrddwebe	138	6	sloughing	sloughing	NN
cord-345472-qrddwebe	138	7	,	,	,
cord-345472-qrddwebe	138	8	and	and	CC
cord-345472-qrddwebe	138	9	lung	lung	NN
cord-345472-qrddwebe	138	10	neutrophil	neutrophil	NN
cord-345472-qrddwebe	138	11	infiltration	infiltration	NN
cord-345472-qrddwebe	138	12	.	.	.
cord-345472-qrddwebe	139	1	Despite	despite	IN
cord-345472-qrddwebe	139	2	the	the	DT
cord-345472-qrddwebe	139	3	lack	lack	NN
cord-345472-qrddwebe	139	4	of	of	IN
cord-345472-qrddwebe	139	5	effect	effect	NN
cord-345472-qrddwebe	139	6	on	on	IN
cord-345472-qrddwebe	139	7	viral	viral	JJ
cord-345472-qrddwebe	139	8	load	load	NN
cord-345472-qrddwebe	139	9	,	,	,
cord-345472-qrddwebe	139	10	the	the	DT
cord-345472-qrddwebe	139	11	attenuated	attenuated	JJ
cord-345472-qrddwebe	139	12	inflammatory	inflammatory	JJ
cord-345472-qrddwebe	139	13	response	response	NN
cord-345472-qrddwebe	139	14	improved	improve	VBD
cord-345472-qrddwebe	139	15	the	the	DT
cord-345472-qrddwebe	139	16	clinical	clinical	JJ
cord-345472-qrddwebe	139	17	score	score	NN
cord-345472-qrddwebe	139	18	.	.	.
cord-345472-qrddwebe	140	1	Additionally	additionally	RB
cord-345472-qrddwebe	140	2	,	,	,
cord-345472-qrddwebe	140	3	the	the	DT
cord-345472-qrddwebe	140	4	adoptive	adoptive	JJ
cord-345472-qrddwebe	140	5	transfer	transfer	NN
cord-345472-qrddwebe	140	6	of	of	IN
cord-345472-qrddwebe	140	7	regulatory	regulatory	JJ
cord-345472-qrddwebe	140	8	T	t	NN
cord-345472-qrddwebe	140	9	-	-	HYPH
cord-345472-qrddwebe	140	10	cells	cell	NNS
cord-345472-qrddwebe	140	11	in	in	IN
cord-345472-qrddwebe	140	12	early	early	JJ
cord-345472-qrddwebe	140	13	life	life	NN
cord-345472-qrddwebe	140	14	was	be	VBD
cord-345472-qrddwebe	140	15	sufficient	sufficient	JJ
cord-345472-qrddwebe	140	16	to	to	TO
cord-345472-qrddwebe	140	17	protect	protect	VB
cord-345472-qrddwebe	140	18	against	against	IN
cord-345472-qrddwebe	140	19	the	the	DT
cord-345472-qrddwebe	140	20	later	later	JJ
cord-345472-qrddwebe	140	21	development	development	NN
cord-345472-qrddwebe	140	22	of	of	IN
cord-345472-qrddwebe	140	23	experimental	experimental	JJ
cord-345472-qrddwebe	140	24	asthma	asthma	NN
cord-345472-qrddwebe	140	25	[	[	-LRB-
cord-345472-qrddwebe	140	26	80	80	CD
cord-345472-qrddwebe	140	27	]	]	-RRB-
cord-345472-qrddwebe	140	28	.	.	.
cord-345472-qrddwebe	141	1	These	these	DT
cord-345472-qrddwebe	141	2	data	datum	NNS
cord-345472-qrddwebe	141	3	suggest	suggest	VBP
cord-345472-qrddwebe	141	4	that	that	IN
cord-345472-qrddwebe	141	5	therapies	therapy	NNS
cord-345472-qrddwebe	141	6	that	that	WDT
cord-345472-qrddwebe	141	7	enhance	enhance	VBP
cord-345472-qrddwebe	141	8	immunoregulation	immunoregulation	NN
cord-345472-qrddwebe	141	9	will	will	MD
cord-345472-qrddwebe	141	10	both	both	DT
cord-345472-qrddwebe	141	11	ameliorate	ameliorate	VB
cord-345472-qrddwebe	141	12	the	the	DT
cord-345472-qrddwebe	141	13	severity	severity	NN
cord-345472-qrddwebe	141	14	of	of	IN
cord-345472-qrddwebe	141	15	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	141	16	and	and	CC
cord-345472-qrddwebe	141	17	break	break	VB
cord-345472-qrddwebe	141	18	its	-PRON-	PRP$
cord-345472-qrddwebe	141	19	nexus	nexus	NN
cord-345472-qrddwebe	141	20	with	with	IN
cord-345472-qrddwebe	141	21	the	the	DT
cord-345472-qrddwebe	141	22	development	development	NN
cord-345472-qrddwebe	141	23	of	of	IN
cord-345472-qrddwebe	141	24	asthma	asthma	NN
cord-345472-qrddwebe	141	25	.	.	.
cord-345472-qrddwebe	142	1	DAMPs	damp	NNS
cord-345472-qrddwebe	142	2	can	can	MD
cord-345472-qrddwebe	142	3	indirectly	indirectly	RB
cord-345472-qrddwebe	142	4	promote	promote	VB
cord-345472-qrddwebe	142	5	neutrophilic	neutrophilic	JJ
cord-345472-qrddwebe	142	6	inflammation	inflammation	NN
cord-345472-qrddwebe	142	7	by	by	IN
cord-345472-qrddwebe	142	8	inducing	induce	VBG
cord-345472-qrddwebe	142	9	the	the	DT
cord-345472-qrddwebe	142	10	production	production	NN
cord-345472-qrddwebe	142	11	of	of	IN
cord-345472-qrddwebe	142	12	neutrophil	neutrophil	NN
cord-345472-qrddwebe	142	13	-	-	HYPH
cord-345472-qrddwebe	142	14	active	active	JJ
cord-345472-qrddwebe	142	15	chemoattractants	chemoattractant	NNS
cord-345472-qrddwebe	142	16	(	(	-LRB-
cord-345472-qrddwebe	142	17	Table	table	NN
cord-345472-qrddwebe	142	18	2	2	CD
cord-345472-qrddwebe	142	19	)	)	-RRB-
cord-345472-qrddwebe	142	20	,	,	,
cord-345472-qrddwebe	142	21	such	such	JJ
cord-345472-qrddwebe	142	22	as	as	IN
cord-345472-qrddwebe	142	23	IL-8	IL-8	NNP
cord-345472-qrddwebe	142	24	[	[	-LRB-
cord-345472-qrddwebe	142	25	85	85	CD
cord-345472-qrddwebe	142	26	]	]	-RRB-
cord-345472-qrddwebe	142	27	and	and	CC
cord-345472-qrddwebe	142	28	leukotriene	leukotriene	NN
cord-345472-qrddwebe	142	29	B4	B4	NNP
cord-345472-qrddwebe	142	30	(	(	-LRB-
cord-345472-qrddwebe	142	31	LTB4	LTB4	NNP
cord-345472-qrddwebe	142	32	)	)	-RRB-
cord-345472-qrddwebe	142	33	[	[	-LRB-
cord-345472-qrddwebe	142	34	86	86	CD
cord-345472-qrddwebe	142	35	]	]	-RRB-
cord-345472-qrddwebe	142	36	.	.	.
cord-345472-qrddwebe	143	1	IL-8	IL-8	NNP
cord-345472-qrddwebe	143	2	levels	level	NNS
cord-345472-qrddwebe	143	3	correlate	correlate	VBP
cord-345472-qrddwebe	143	4	with	with	IN
cord-345472-qrddwebe	143	5	neutrophil	neutrophil	NN
cord-345472-qrddwebe	143	6	numbers	number	NNS
cord-345472-qrddwebe	143	7	in	in	IN
cord-345472-qrddwebe	143	8	the	the	DT
cord-345472-qrddwebe	143	9	airways	airway	NNS
cord-345472-qrddwebe	143	10	and	and	CC
cord-345472-qrddwebe	143	11	are	be	VBP
cord-345472-qrddwebe	143	12	elevated	elevate	VBN
cord-345472-qrddwebe	143	13	in	in	IN
cord-345472-qrddwebe	143	14	nasal	nasal	NN
cord-345472-qrddwebe	143	15	washes	wash	NNS
cord-345472-qrddwebe	143	16	of	of	IN
cord-345472-qrddwebe	143	17	RSV	RSV	NNP
cord-345472-qrddwebe	143	18	-	-	HYPH
cord-345472-qrddwebe	143	19	infected	infect	VBN
cord-345472-qrddwebe	143	20	children	child	NNS
cord-345472-qrddwebe	143	21	[	[	-LRB-
cord-345472-qrddwebe	143	22	68	68	CD
cord-345472-qrddwebe	143	23	]	]	-RRB-
cord-345472-qrddwebe	143	24	.	.	.
cord-345472-qrddwebe	144	1	Moreover	moreover	RB
cord-345472-qrddwebe	144	2	,	,	,
cord-345472-qrddwebe	144	3	genetic	genetic	JJ
cord-345472-qrddwebe	144	4	polymorphisms	polymorphism	NNS
cord-345472-qrddwebe	144	5	in	in	IN
cord-345472-qrddwebe	144	6	the	the	DT
cord-345472-qrddwebe	144	7	IL-8-encoding	il-8-encoding	NN
cord-345472-qrddwebe	144	8	gene	gene	NN
cord-345472-qrddwebe	144	9	that	that	WDT
cord-345472-qrddwebe	144	10	increase	increase	VBP
cord-345472-qrddwebe	144	11	IL-8	il-8	NN
cord-345472-qrddwebe	144	12	production	production	NN
cord-345472-qrddwebe	144	13	are	be	VBP
cord-345472-qrddwebe	144	14	associated	associate	VBN
cord-345472-qrddwebe	144	15	with	with	IN
cord-345472-qrddwebe	144	16	increased	increase	VBN
cord-345472-qrddwebe	144	17	severity	severity	NN
cord-345472-qrddwebe	144	18	of	of	IN
cord-345472-qrddwebe	144	19	RSV	RSV	NNP
cord-345472-qrddwebe	144	20	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	144	21	[	[	-LRB-
cord-345472-qrddwebe	144	22	87	87	CD
cord-345472-qrddwebe	144	23	]	]	-RRB-
cord-345472-qrddwebe	144	24	,	,	,
cord-345472-qrddwebe	144	25	and	and	CC
cord-345472-qrddwebe	144	26	pharmacological	pharmacological	JJ
cord-345472-qrddwebe	144	27	inhibition	inhibition	NN
cord-345472-qrddwebe	144	28	of	of	IN
cord-345472-qrddwebe	144	29	IL-8	IL-8	NNP
cord-345472-qrddwebe	144	30	in	in	IN
cord-345472-qrddwebe	144	31	humans	human	NNS
cord-345472-qrddwebe	144	32	reduces	reduce	VBZ
cord-345472-qrddwebe	144	33	neutrophilia	neutrophilia	NNP
cord-345472-qrddwebe	144	34	and	and	CC
cord-345472-qrddwebe	144	35	improves	improve	VBZ
cord-345472-qrddwebe	144	36	clinical	clinical	JJ
cord-345472-qrddwebe	144	37	outcomes	outcome	NNS
cord-345472-qrddwebe	144	38	[	[	-LRB-
cord-345472-qrddwebe	144	39	88	88	CD
cord-345472-qrddwebe	144	40	]	]	-RRB-
cord-345472-qrddwebe	144	41	.	.	.
cord-345472-qrddwebe	145	1	Levels	level	NNS
cord-345472-qrddwebe	145	2	of	of	IN
cord-345472-qrddwebe	145	3	the	the	DT
cord-345472-qrddwebe	145	4	eicosanoid	eicosanoid	NNP
cord-345472-qrddwebe	145	5	LTB4	LTB4	NNP
cord-345472-qrddwebe	145	6	are	be	VBP
cord-345472-qrddwebe	145	7	elevated	elevate	VBN
cord-345472-qrddwebe	145	8	in	in	IN
cord-345472-qrddwebe	145	9	endotracheal	endotracheal	NN
cord-345472-qrddwebe	145	10	aspirates	aspirate	NNS
cord-345472-qrddwebe	145	11	of	of	IN
cord-345472-qrddwebe	145	12	infants	infant	NNS
cord-345472-qrddwebe	145	13	with	with	IN
cord-345472-qrddwebe	145	14	RSV	RSV	NNP
cord-345472-qrddwebe	145	15	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	145	16	compared	compare	VBN
cord-345472-qrddwebe	145	17	with	with	IN
cord-345472-qrddwebe	145	18	healthy	healthy	JJ
cord-345472-qrddwebe	145	19	controls	control	NNS
cord-345472-qrddwebe	145	20	[	[	-LRB-
cord-345472-qrddwebe	145	21	89	89	CD
cord-345472-qrddwebe	145	22	]	]	-RRB-
cord-345472-qrddwebe	145	23	,	,	,
cord-345472-qrddwebe	145	24	and	and	CC
cord-345472-qrddwebe	145	25	are	be	VBP
cord-345472-qrddwebe	145	26	associated	associate	VBN
cord-345472-qrddwebe	145	27	with	with	IN
cord-345472-qrddwebe	145	28	increased	increase	VBN
cord-345472-qrddwebe	145	29	neutrophilic	neutrophilic	JJ
cord-345472-qrddwebe	145	30	responses	response	NNS
cord-345472-qrddwebe	145	31	[	[	-LRB-
cord-345472-qrddwebe	145	32	90	90	CD
cord-345472-qrddwebe	145	33	]	]	-RRB-
cord-345472-qrddwebe	145	34	.	.	.
cord-345472-qrddwebe	146	1	Treatment	treatment	NN
cord-345472-qrddwebe	146	2	of	of	IN
cord-345472-qrddwebe	146	3	RSV	RSV	NNP
cord-345472-qrddwebe	146	4	-	-	HYPH
cord-345472-qrddwebe	146	5	infected	infect	VBN
cord-345472-qrddwebe	146	6	mice	mouse	NNS
cord-345472-qrddwebe	146	7	with	with	IN
cord-345472-qrddwebe	146	8	the	the	DT
cord-345472-qrddwebe	146	9	leukotriene	leukotriene	NN
cord-345472-qrddwebe	146	10	inhibitor	inhibitor	NN
cord-345472-qrddwebe	146	11	zileuton	zileuton	NNP
cord-345472-qrddwebe	146	12	reduces	reduce	VBZ
cord-345472-qrddwebe	146	13	cellular	cellular	JJ
cord-345472-qrddwebe	146	14	inflammation	inflammation	NN
cord-345472-qrddwebe	146	15	(	(	-LRB-
cord-345472-qrddwebe	146	16	including	include	VBG
cord-345472-qrddwebe	146	17	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	146	18	)	)	-RRB-
cord-345472-qrddwebe	146	19	in	in	IN
cord-345472-qrddwebe	146	20	the	the	DT
cord-345472-qrddwebe	146	21	lung	lung	NN
cord-345472-qrddwebe	146	22	,	,	,
cord-345472-qrddwebe	146	23	prevents	prevent	VBZ
cord-345472-qrddwebe	146	24	RSV	RSV	NNP
cord-345472-qrddwebe	146	25	-	-	HYPH
cord-345472-qrddwebe	146	26	induced	induce	VBN
cord-345472-qrddwebe	146	27	weight	weight	NN
cord-345472-qrddwebe	146	28	loss	loss	NN
cord-345472-qrddwebe	146	29	and	and	CC
cord-345472-qrddwebe	146	30	decreases	decrease	VBZ
cord-345472-qrddwebe	146	31	airway	airway	NN
cord-345472-qrddwebe	146	32	pathology	pathology	NN
cord-345472-qrddwebe	146	33	compared	compare	VBN
cord-345472-qrddwebe	146	34	with	with	IN
cord-345472-qrddwebe	146	35	untreated	untreated	JJ
cord-345472-qrddwebe	146	36	control	control	NN
cord-345472-qrddwebe	146	37	mice	mouse	NNS
cord-345472-qrddwebe	146	38	[	[	-LRB-
cord-345472-qrddwebe	146	39	91	91	CD
cord-345472-qrddwebe	146	40	]	]	-RRB-
cord-345472-qrddwebe	146	41	.	.	.
cord-345472-qrddwebe	147	1	Mice	mouse	NNS
cord-345472-qrddwebe	147	2	lacking	lack	VBG
cord-345472-qrddwebe	147	3	CCL3	CCL3	NNP
cord-345472-qrddwebe	147	4	or	or	CC
cord-345472-qrddwebe	147	5	its	-PRON-	PRP$
cord-345472-qrddwebe	147	6	receptor	receptor	NN
cord-345472-qrddwebe	147	7	CCR1	CCR1	NNP
cord-345472-qrddwebe	147	8	display	display	NN
cord-345472-qrddwebe	147	9	significantly	significantly	RB
cord-345472-qrddwebe	147	10	reduced	reduce	VBN
cord-345472-qrddwebe	147	11	numbers	number	NNS
cord-345472-qrddwebe	147	12	of	of	IN
cord-345472-qrddwebe	147	13	airway	airway	JJ
cord-345472-qrddwebe	147	14	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	147	15	in	in	IN
cord-345472-qrddwebe	147	16	response	response	NN
cord-345472-qrddwebe	147	17	to	to	IN
cord-345472-qrddwebe	147	18	infection	infection	NN
cord-345472-qrddwebe	147	19	with	with	IN
cord-345472-qrddwebe	147	20	PVM	PVM	NNP
cord-345472-qrddwebe	147	21	[	[	-LRB-
cord-345472-qrddwebe	147	22	92	92	CD
cord-345472-qrddwebe	147	23	,	,	,
cord-345472-qrddwebe	147	24	93	93	CD
cord-345472-qrddwebe	147	25	]	]	-RRB-
cord-345472-qrddwebe	147	26	.	.	.
cord-345472-qrddwebe	148	1	Moreover	moreover	RB
cord-345472-qrddwebe	148	2	,	,	,
cord-345472-qrddwebe	148	3	the	the	DT
cord-345472-qrddwebe	148	4	blockade	blockade	NN
cord-345472-qrddwebe	148	5	of	of	IN
cord-345472-qrddwebe	148	6	CCL3	CCL3	NNP
cord-345472-qrddwebe	148	7	/	/	SYM
cord-345472-qrddwebe	148	8	CCR1	CCR1	NNP
cord-345472-qrddwebe	148	9	in	in	IN
cord-345472-qrddwebe	148	10	combination	combination	NN
cord-345472-qrddwebe	148	11	with	with	IN
cord-345472-qrddwebe	148	12	antiviral	antiviral	JJ
cord-345472-qrddwebe	148	13	therapy	therapy	NN
cord-345472-qrddwebe	148	14	improves	improve	VBZ
cord-345472-qrddwebe	148	15	the	the	DT
cord-345472-qrddwebe	148	16	survival	survival	NN
cord-345472-qrddwebe	148	17	of	of	IN
cord-345472-qrddwebe	148	18	mice	mouse	NNS
cord-345472-qrddwebe	148	19	infected	infect	VBN
cord-345472-qrddwebe	148	20	with	with	IN
cord-345472-qrddwebe	148	21	a	a	DT
cord-345472-qrddwebe	148	22	lethal	lethal	JJ
cord-345472-qrddwebe	148	23	PVM	PVM	NNP
cord-345472-qrddwebe	148	24	dose	dose	NN
cord-345472-qrddwebe	148	25	[	[	-LRB-
cord-345472-qrddwebe	148	26	94	94	CD
cord-345472-qrddwebe	148	27	]	]	-RRB-
cord-345472-qrddwebe	148	28	.	.	.
cord-345472-qrddwebe	149	1	DAMPs	damp	NNS
cord-345472-qrddwebe	149	2	can	can	MD
cord-345472-qrddwebe	149	3	also	also	RB
cord-345472-qrddwebe	149	4	promote	promote	VB
cord-345472-qrddwebe	149	5	γδ	γδ	NN
cord-345472-qrddwebe	149	6	-	-	HYPH
cord-345472-qrddwebe	149	7	T	t	NN
cord-345472-qrddwebe	149	8	cells	cell	NNS
cord-345472-qrddwebe	149	9	[	[	-LRB-
cord-345472-qrddwebe	149	10	95	95	CD
cord-345472-qrddwebe	149	11	]	]	-RRB-
cord-345472-qrddwebe	149	12	and	and	CC
cord-345472-qrddwebe	149	13	CD4	CD4	NNP
cord-345472-qrddwebe	149	14	+	+	CC
cord-345472-qrddwebe	149	15	TH17	TH17	NNP
cord-345472-qrddwebe	149	16	cells	cell	NNS
cord-345472-qrddwebe	149	17	[	[	-LRB-
cord-345472-qrddwebe	149	18	96	96	CD
cord-345472-qrddwebe	149	19	]	]	-RRB-
cord-345472-qrddwebe	149	20	to	to	TO
cord-345472-qrddwebe	149	21	produce	produce	VB
cord-345472-qrddwebe	149	22	IL-17A	IL-17A	NNP
cord-345472-qrddwebe	149	23	[	[	-LRB-
cord-345472-qrddwebe	149	24	96	96	CD
cord-345472-qrddwebe	149	25	]	]	-RRB-
cord-345472-qrddwebe	149	26	[	[	-LRB-
cord-345472-qrddwebe	149	27	97	97	CD
cord-345472-qrddwebe	149	28	]	]	-RRB-
cord-345472-qrddwebe	149	29	[	[	-LRB-
cord-345472-qrddwebe	149	30	98	98	CD
cord-345472-qrddwebe	149	31	]	]	-RRB-
cord-345472-qrddwebe	149	32	,	,	,
cord-345472-qrddwebe	149	33	which	which	WDT
cord-345472-qrddwebe	149	34	is	be	VBZ
cord-345472-qrddwebe	149	35	elevated	elevate	VBN
cord-345472-qrddwebe	149	36	in	in	IN
cord-345472-qrddwebe	149	37	nasal	nasal	NN
cord-345472-qrddwebe	149	38	aspirates	aspirate	NNS
cord-345472-qrddwebe	149	39	from	from	IN
cord-345472-qrddwebe	149	40	RSV	RSV	NNP
cord-345472-qrddwebe	149	41	-	-	HYPH
cord-345472-qrddwebe	149	42	infected	infect	VBN
cord-345472-qrddwebe	149	43	infants	infant	NNS
cord-345472-qrddwebe	149	44	in	in	IN
cord-345472-qrddwebe	149	45	comparison	comparison	NN
cord-345472-qrddwebe	149	46	with	with	IN
cord-345472-qrddwebe	149	47	uninfected	uninfected	JJ
cord-345472-qrddwebe	149	48	controls	control	NNS
cord-345472-qrddwebe	149	49	[	[	-LRB-
cord-345472-qrddwebe	149	50	99	99	CD
cord-345472-qrddwebe	149	51	]	]	-RRB-
cord-345472-qrddwebe	149	52	.	.	.
cord-345472-qrddwebe	150	1	IL-17A	il-17a	NN
cord-345472-qrddwebe	150	2	augments	augment	VBZ
cord-345472-qrddwebe	150	3	neutrophil	neutrophil	NN
cord-345472-qrddwebe	150	4	recruitment	recruitment	NN
cord-345472-qrddwebe	150	5	into	into	IN
cord-345472-qrddwebe	150	6	the	the	DT
cord-345472-qrddwebe	150	7	lung	lung	NN
cord-345472-qrddwebe	150	8	by	by	IN
cord-345472-qrddwebe	150	9	stimulating	stimulate	VBG
cord-345472-qrddwebe	150	10	the	the	DT
cord-345472-qrddwebe	150	11	production	production	NN
cord-345472-qrddwebe	150	12	of	of	IN
cord-345472-qrddwebe	150	13	IL-8	il-8	NN
cord-345472-qrddwebe	150	14	and	and	CC
cord-345472-qrddwebe	150	15	leukotrienes	leukotriene	NNS
cord-345472-qrddwebe	150	16	by	by	IN
cord-345472-qrddwebe	150	17	microvascular	microvascular	JJ
cord-345472-qrddwebe	150	18	endothelial	endothelial	NN
cord-345472-qrddwebe	150	19	and	and	CC
cord-345472-qrddwebe	150	20	lung	lung	NN
cord-345472-qrddwebe	150	21	epithelial	epithelial	JJ
cord-345472-qrddwebe	150	22	cells	cell	NNS
cord-345472-qrddwebe	150	23	[	[	-LRB-
cord-345472-qrddwebe	150	24	100	100	CD
cord-345472-qrddwebe	150	25	,	,	,
cord-345472-qrddwebe	150	26	101	101	CD
cord-345472-qrddwebe	150	27	]	]	-RRB-
cord-345472-qrddwebe	150	28	.	.	.
cord-345472-qrddwebe	151	1	In	in	IN
cord-345472-qrddwebe	151	2	addition	addition	NN
cord-345472-qrddwebe	151	3	,	,	,
cord-345472-qrddwebe	151	4	IL-17	IL-17	NNP
cord-345472-qrddwebe	151	5	activates	activate	VBZ
cord-345472-qrddwebe	151	6	p38	p38	CD
cord-345472-qrddwebe	151	7	MAPK	MAPK	NNP
cord-345472-qrddwebe	151	8	-	-	HYPH
cord-345472-qrddwebe	151	9	induced	induce	VBN
cord-345472-qrddwebe	151	10	expression	expression	NN
cord-345472-qrddwebe	151	11	of	of	IN
cord-345472-qrddwebe	151	12	endothelial	endothelial	JJ
cord-345472-qrddwebe	151	13	adhesion	adhesion	NN
cord-345472-qrddwebe	151	14	markers	marker	NNS
cord-345472-qrddwebe	151	15	(	(	-LRB-
cord-345472-qrddwebe	151	16	E	e	NN
cord-345472-qrddwebe	151	17	-	-	NN
cord-345472-qrddwebe	151	18	selectin	selectin	JJ
cord-345472-qrddwebe	151	19	,	,	,
cord-345472-qrddwebe	151	20	VCAM-1	VCAM-1	NNP
cord-345472-qrddwebe	151	21	,	,	,
cord-345472-qrddwebe	151	22	and	and	CC
cord-345472-qrddwebe	151	23	ICAM-1	ICAM-1	NNP
cord-345472-qrddwebe	151	24	)	)	-RRB-
cord-345472-qrddwebe	151	25	on	on	IN
cord-345472-qrddwebe	151	26	lung	lung	NN
cord-345472-qrddwebe	151	27	endothelial	endothelial	NN
cord-345472-qrddwebe	151	28	cells	cell	NNS
cord-345472-qrddwebe	151	29	,	,	,
cord-345472-qrddwebe	151	30	promoting	promote	VBG
cord-345472-qrddwebe	151	31	trans	trans	JJ
cord-345472-qrddwebe	151	32	-	-	JJ
cord-345472-qrddwebe	151	33	endothelial	endothelial	JJ
cord-345472-qrddwebe	151	34	migration	migration	NN
cord-345472-qrddwebe	151	35	of	of	IN
cord-345472-qrddwebe	151	36	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	151	37	.	.	.
cord-345472-qrddwebe	152	1	Lack	lack	NN
cord-345472-qrddwebe	152	2	of	of	IN
cord-345472-qrddwebe	152	3	IL-17	IL-17	NNP
cord-345472-qrddwebe	152	4	in	in	IN
cord-345472-qrddwebe	152	5	RSV	RSV	NNP
cord-345472-qrddwebe	152	6	-	-	HYPH
cord-345472-qrddwebe	152	7	infected	infect	VBN
cord-345472-qrddwebe	152	8	mice	mouse	NNS
cord-345472-qrddwebe	152	9	reduces	reduce	VBZ
cord-345472-qrddwebe	152	10	neutrophil	neutrophil	NN
cord-345472-qrddwebe	152	11	numbers	number	NNS
cord-345472-qrddwebe	152	12	in	in	IN
cord-345472-qrddwebe	152	13	the	the	DT
cord-345472-qrddwebe	152	14	lung	lung	NN
cord-345472-qrddwebe	152	15	,	,	,
cord-345472-qrddwebe	152	16	limits	limit	VBZ
cord-345472-qrddwebe	152	17	mucus	mucus	NN
cord-345472-qrddwebe	152	18	production	production	NN
cord-345472-qrddwebe	152	19	,	,	,
cord-345472-qrddwebe	152	20	and	and	CC
cord-345472-qrddwebe	152	21	improves	improve	VBZ
cord-345472-qrddwebe	152	22	the	the	DT
cord-345472-qrddwebe	152	23	cytotoxic	cytotoxic	JJ
cord-345472-qrddwebe	152	24	T	t	NN
cord-345472-qrddwebe	152	25	-	-	HYPH
cord-345472-qrddwebe	152	26	cell	cell	NN
cord-345472-qrddwebe	152	27	(	(	-LRB-
cord-345472-qrddwebe	152	28	CTL	CTL	NNP
cord-345472-qrddwebe	152	29	)	)	-RRB-
cord-345472-qrddwebe	152	30	responses	response	NNS
cord-345472-qrddwebe	152	31	against	against	IN
cord-345472-qrddwebe	152	32	RSV	RSV	NNP
cord-345472-qrddwebe	152	33	[	[	-LRB-
cord-345472-qrddwebe	152	34	99	99	CD
cord-345472-qrddwebe	152	35	]	]	-RRB-
cord-345472-qrddwebe	152	36	.	.	.
cord-345472-qrddwebe	153	1	However	however	RB
cord-345472-qrddwebe	153	2	,	,	,
cord-345472-qrddwebe	153	3	the	the	DT
cord-345472-qrddwebe	153	4	mechanism	mechanism	NN
cord-345472-qrddwebe	153	5	by	by	IN
cord-345472-qrddwebe	153	6	which	which	WDT
cord-345472-qrddwebe	153	7	IL-17	IL-17	NNP
cord-345472-qrddwebe	153	8	deficiency	deficiency	NN
cord-345472-qrddwebe	153	9	enhances	enhance	VBZ
cord-345472-qrddwebe	153	10	CTL	CTL	NNP
cord-345472-qrddwebe	153	11	responses	response	NNS
cord-345472-qrddwebe	153	12	to	to	IN
cord-345472-qrddwebe	153	13	RSV	RSV	NNP
cord-345472-qrddwebe	153	14	remains	remain	VBZ
cord-345472-qrddwebe	153	15	unknown	unknown	JJ
cord-345472-qrddwebe	153	16	.	.	.
cord-345472-qrddwebe	154	1	Nonetheless	nonetheless	RB
cord-345472-qrddwebe	154	2	,	,	,
cord-345472-qrddwebe	154	3	inhibiting	inhibit	VBG
cord-345472-qrddwebe	154	4	IL-17	IL-17	NNP
cord-345472-qrddwebe	154	5	signalling	signalling	NN
cord-345472-qrddwebe	154	6	may	may	MD
cord-345472-qrddwebe	154	7	prevent	prevent	VB
cord-345472-qrddwebe	154	8	neutrophil	neutrophil	NN
cord-345472-qrddwebe	154	9	-	-	HYPH
cord-345472-qrddwebe	154	10	induced	induce	VBN
cord-345472-qrddwebe	154	11	inflammation	inflammation	NN
cord-345472-qrddwebe	154	12	and	and	CC
cord-345472-qrddwebe	154	13	pathology	pathology	NN
cord-345472-qrddwebe	154	14	during	during	IN
cord-345472-qrddwebe	154	15	RSV	RSV	NNP
cord-345472-qrddwebe	154	16	infection	infection	NN
cord-345472-qrddwebe	154	17	.	.	.
cord-345472-qrddwebe	155	1	Induce	induce	VB
cord-345472-qrddwebe	155	2	secretion	secretion	NN
cord-345472-qrddwebe	155	3	of	of	IN
cord-345472-qrddwebe	155	4	pro	pro	JJ
cord-345472-qrddwebe	155	5	-	-	JJ
cord-345472-qrddwebe	155	6	inflammatory	inflammatory	JJ
cord-345472-qrddwebe	155	7	cytokines	cytokine	NNS
cord-345472-qrddwebe	155	8	,	,	,
cord-345472-qrddwebe	155	9	drive	drive	VB
cord-345472-qrddwebe	155	10	ILC2	ilc2	CD
cord-345472-qrddwebe	155	11	responses	response	NNS
cord-345472-qrddwebe	155	12	,	,	,
cord-345472-qrddwebe	155	13	induce	induce	VB
cord-345472-qrddwebe	155	14	necroptosis	necroptosis	NN
cord-345472-qrddwebe	155	15	and	and	CC
cord-345472-qrddwebe	155	16	AEC	AEC	NNP
cord-345472-qrddwebe	155	17	death	death	NN
cord-345472-qrddwebe	155	18	[	[	-LRB-
cord-345472-qrddwebe	155	19	76	76	CD
cord-345472-qrddwebe	155	20	,	,	,
cord-345472-qrddwebe	155	21	83	83	CD
cord-345472-qrddwebe	155	22	]	]	-RRB-
cord-345472-qrddwebe	155	23	 	 	_SP
cord-345472-qrddwebe	156	1	Neutrophils	neutrophil	NNS
cord-345472-qrddwebe	156	2	have	have	VBP
cord-345472-qrddwebe	156	3	traditionally	traditionally	RB
cord-345472-qrddwebe	156	4	been	be	VBN
cord-345472-qrddwebe	156	5	viewed	view	VBN
cord-345472-qrddwebe	156	6	as	as	IN
cord-345472-qrddwebe	156	7	a	a	DT
cord-345472-qrddwebe	156	8	homogenous	homogenous	JJ
cord-345472-qrddwebe	156	9	cell	cell	NN
cord-345472-qrddwebe	156	10	population	population	NN
cord-345472-qrddwebe	156	11	.	.	.
cord-345472-qrddwebe	157	1	However	however	RB
cord-345472-qrddwebe	157	2	,	,	,
cord-345472-qrddwebe	157	3	it	-PRON-	PRP
cord-345472-qrddwebe	157	4	is	be	VBZ
cord-345472-qrddwebe	157	5	now	now	RB
cord-345472-qrddwebe	157	6	appreciated	appreciate	VBN
cord-345472-qrddwebe	157	7	that	that	IN
cord-345472-qrddwebe	157	8	diversity	diversity	NN
cord-345472-qrddwebe	157	9	exists	exist	VBZ
cord-345472-qrddwebe	157	10	at	at	IN
cord-345472-qrddwebe	157	11	the	the	DT
cord-345472-qrddwebe	157	12	molecular	molecular	JJ
cord-345472-qrddwebe	157	13	,	,	,
cord-345472-qrddwebe	157	14	phenotypic	phenotypic	JJ
cord-345472-qrddwebe	157	15	,	,	,
cord-345472-qrddwebe	157	16	and	and	CC
cord-345472-qrddwebe	157	17	functional	functional	JJ
cord-345472-qrddwebe	157	18	level	level	NN
cord-345472-qrddwebe	157	19	[	[	-LRB-
cord-345472-qrddwebe	157	20	11	11	CD
cord-345472-qrddwebe	157	21	,	,	,
cord-345472-qrddwebe	157	22	13	13	CD
cord-345472-qrddwebe	157	23	,	,	,
cord-345472-qrddwebe	157	24	112	112	CD
cord-345472-qrddwebe	157	25	,	,	,
cord-345472-qrddwebe	157	26	113	113	CD
cord-345472-qrddwebe	157	27	]	]	-RRB-
cord-345472-qrddwebe	157	28	.	.	.
cord-345472-qrddwebe	158	1	This	this	DT
cord-345472-qrddwebe	158	2	heterogeneity	heterogeneity	NN
cord-345472-qrddwebe	158	3	is	be	VBZ
cord-345472-qrddwebe	158	4	a	a	DT
cord-345472-qrddwebe	158	5	consequence	consequence	NN
cord-345472-qrddwebe	158	6	of	of	IN
cord-345472-qrddwebe	158	7	differences	difference	NNS
cord-345472-qrddwebe	158	8	in	in	IN
cord-345472-qrddwebe	158	9	proliferative	proliferative	JJ
cord-345472-qrddwebe	158	10	capacity	capacity	NN
cord-345472-qrddwebe	158	11	,	,	,
cord-345472-qrddwebe	158	12	maturation	maturation	NN
cord-345472-qrddwebe	158	13	status	status	NN
cord-345472-qrddwebe	158	14	,	,	,
cord-345472-qrddwebe	158	15	transcriptional	transcriptional	JJ
cord-345472-qrddwebe	158	16	and	and	CC
cord-345472-qrddwebe	158	17	epigenetic	epigenetic	JJ
cord-345472-qrddwebe	158	18	properties	property	NNS
cord-345472-qrddwebe	158	19	,	,	,
cord-345472-qrddwebe	158	20	and	and	CC
cord-345472-qrddwebe	158	21	environmental	environmental	JJ
cord-345472-qrddwebe	158	22	cues	cue	NNS
cord-345472-qrddwebe	158	23	in	in	IN
cord-345472-qrddwebe	158	24	tissues	tissue	NNS
cord-345472-qrddwebe	158	25	[	[	-LRB-
cord-345472-qrddwebe	158	26	11	11	CD
cord-345472-qrddwebe	158	27	]	]	-RRB-
cord-345472-qrddwebe	158	28	.	.	.
cord-345472-qrddwebe	159	1	In	in	IN
cord-345472-qrddwebe	159	2	one	one	CD
cord-345472-qrddwebe	159	3	study	study	NN
cord-345472-qrddwebe	159	4	that	that	WDT
cord-345472-qrddwebe	159	5	employed	employ	VBN
cord-345472-qrddwebe	159	6	Fucci-474	fucci-474	CD
cord-345472-qrddwebe	159	7	reporter	reporter	NN
cord-345472-qrddwebe	159	8	mice	mouse	NNS
cord-345472-qrddwebe	159	9	to	to	TO
cord-345472-qrddwebe	159	10	identify	identify	VB
cord-345472-qrddwebe	159	11	cells	cell	NNS
cord-345472-qrddwebe	159	12	at	at	IN
cord-345472-qrddwebe	159	13	different	different	JJ
cord-345472-qrddwebe	159	14	stages	stage	NNS
cord-345472-qrddwebe	159	15	of	of	IN
cord-345472-qrddwebe	159	16	the	the	DT
cord-345472-qrddwebe	159	17	cell	cell	NN
cord-345472-qrddwebe	159	18	cycle	cycle	NN
cord-345472-qrddwebe	159	19	,	,	,
cord-345472-qrddwebe	159	20	subsequent	subsequent	JJ
cord-345472-qrddwebe	159	21	mass	mass	NN
cord-345472-qrddwebe	159	22	cytometry	cytometry	NN
cord-345472-qrddwebe	159	23	and	and	CC
cord-345472-qrddwebe	159	24	transcriptomic	transcriptomic	NNP
cord-345472-qrddwebe	159	25	analysis	analysis	NN
cord-345472-qrddwebe	159	26	revealed	reveal	VBD
cord-345472-qrddwebe	159	27	the	the	DT
cord-345472-qrddwebe	159	28	existence	existence	NN
cord-345472-qrddwebe	159	29	of	of	IN
cord-345472-qrddwebe	159	30	three	three	CD
cord-345472-qrddwebe	159	31	distinct	distinct	JJ
cord-345472-qrddwebe	159	32	neutrophil	neutrophil	NN
cord-345472-qrddwebe	159	33	subsets	subset	NNS
cord-345472-qrddwebe	159	34	in	in	IN
cord-345472-qrddwebe	159	35	the	the	DT
cord-345472-qrddwebe	159	36	bone	bone	NN
cord-345472-qrddwebe	159	37	marrow	marrow	NN
cord-345472-qrddwebe	159	38	[	[	-LRB-
cord-345472-qrddwebe	159	39	114	114	CD
cord-345472-qrddwebe	159	40	]	]	-RRB-
cord-345472-qrddwebe	159	41	.	.	.
cord-345472-qrddwebe	160	1	These	these	DT
cord-345472-qrddwebe	160	2	subsets	subset	NNS
cord-345472-qrddwebe	160	3	consisted	consist	VBD
cord-345472-qrddwebe	160	4	of	of	IN
cord-345472-qrddwebe	160	5	a	a	DT
cord-345472-qrddwebe	160	6	highly	highly	RB
cord-345472-qrddwebe	160	7	proliferative	proliferative	JJ
cord-345472-qrddwebe	160	8	precursor	precursor	NN
cord-345472-qrddwebe	160	9	that	that	WDT
cord-345472-qrddwebe	160	10	differentiated	differentiate	VBD
cord-345472-qrddwebe	160	11	into	into	IN
cord-345472-qrddwebe	160	12	two	two	CD
cord-345472-qrddwebe	160	13	non	non	JJ
cord-345472-qrddwebe	160	14	-	-	JJ
cord-345472-qrddwebe	160	15	proliferating	proliferating	JJ
cord-345472-qrddwebe	160	16	subsets	subset	NNS
cord-345472-qrddwebe	160	17	,	,	,
cord-345472-qrddwebe	160	18	one	one	CD
cord-345472-qrddwebe	160	19	immature	immature	JJ
cord-345472-qrddwebe	160	20	and	and	CC
cord-345472-qrddwebe	160	21	one	one	CD
cord-345472-qrddwebe	160	22	mature	mature	NN
cord-345472-qrddwebe	160	23	.	.	.
cord-345472-qrddwebe	161	1	The	the	DT
cord-345472-qrddwebe	161	2	precursor	precursor	NN
cord-345472-qrddwebe	161	3	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	161	4	were	be	VBD
cord-345472-qrddwebe	161	5	Ly6Gand	Ly6Gand	NNP
cord-345472-qrddwebe	161	6	CXCR2-negative	cxcr2-negative	CD
cord-345472-qrddwebe	161	7	,	,	,
cord-345472-qrddwebe	161	8	but	but	CC
cord-345472-qrddwebe	161	9	expressed	express	VBD
cord-345472-qrddwebe	161	10	high	high	JJ
cord-345472-qrddwebe	161	11	levels	level	NNS
cord-345472-qrddwebe	161	12	of	of	IN
cord-345472-qrddwebe	161	13	cKit	cKit	NNP
cord-345472-qrddwebe	161	14	and	and	CC
cord-345472-qrddwebe	161	15	CXCR4	CXCR4	NNS
cord-345472-qrddwebe	161	16	.	.	.
cord-345472-qrddwebe	162	1	The	the	DT
cord-345472-qrddwebe	162	2	immature	immature	JJ
cord-345472-qrddwebe	162	3	subset	subset	NN
cord-345472-qrddwebe	162	4	displayed	display	VBD
cord-345472-qrddwebe	162	5	low	low	JJ
cord-345472-qrddwebe	162	6	levels	level	NNS
cord-345472-qrddwebe	162	7	of	of	IN
cord-345472-qrddwebe	162	8	surface	surface	NN
cord-345472-qrddwebe	162	9	Ly6	Ly6	NNP
cord-345472-qrddwebe	162	10	G	g	NN
cord-345472-qrddwebe	162	11	and	and	CC
cord-345472-qrddwebe	162	12	CXCR2	CXCR2	NNS
cord-345472-qrddwebe	162	13	and	and	CC
cord-345472-qrddwebe	162	14	was	be	VBD
cord-345472-qrddwebe	162	15	positive	positive	JJ
cord-345472-qrddwebe	162	16	for	for	IN
cord-345472-qrddwebe	162	17	CXCR4	CXCR4	NNS
cord-345472-qrddwebe	162	18	.	.	.
cord-345472-qrddwebe	163	1	The	the	DT
cord-345472-qrddwebe	163	2	mature	mature	JJ
cord-345472-qrddwebe	163	3	subset	subset	VBN
cord-345472-qrddwebe	163	4	displayed	display	VBD
cord-345472-qrddwebe	163	5	higher	high	JJR
cord-345472-qrddwebe	163	6	levels	level	NNS
cord-345472-qrddwebe	163	7	of	of	IN
cord-345472-qrddwebe	163	8	Ly6	ly6	NN
cord-345472-qrddwebe	163	9	G	g	NN
cord-345472-qrddwebe	163	10	,	,	,
cord-345472-qrddwebe	163	11	CXCR2	CXCR2	NNS
cord-345472-qrddwebe	163	12	,	,	,
cord-345472-qrddwebe	163	13	and	and	CC
cord-345472-qrddwebe	163	14	CD101	CD101	NNP
cord-345472-qrddwebe	163	15	expression	expression	NN
cord-345472-qrddwebe	163	16	and	and	CC
cord-345472-qrddwebe	163	17	lacked	lack	VBD
cord-345472-qrddwebe	163	18	surface	surface	NN
cord-345472-qrddwebe	163	19	CXCR4	CXCR4	NNS
cord-345472-qrddwebe	163	20	.	.	.
cord-345472-qrddwebe	164	1	Immature	immature	JJ
cord-345472-qrddwebe	164	2	and	and	CC
cord-345472-qrddwebe	164	3	mature	mature	JJ
cord-345472-qrddwebe	164	4	neutrophil	neutrophil	NN
cord-345472-qrddwebe	164	5	subsets	subset	NNS
cord-345472-qrddwebe	164	6	were	be	VBD
cord-345472-qrddwebe	164	7	subsequently	subsequently	RB
cord-345472-qrddwebe	164	8	identified	identify	VBN
cord-345472-qrddwebe	164	9	in	in	IN
cord-345472-qrddwebe	164	10	human	human	JJ
cord-345472-qrddwebe	164	11	blood	blood	NN
cord-345472-qrddwebe	164	12	,	,	,
cord-345472-qrddwebe	164	13	with	with	IN
cord-345472-qrddwebe	164	14	immature	immature	JJ
cord-345472-qrddwebe	164	15	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	164	16	associating	associate	VBG
cord-345472-qrddwebe	164	17	with	with	IN
cord-345472-qrddwebe	164	18	increased	increase	VBN
cord-345472-qrddwebe	164	19	tumour	tumour	NN
cord-345472-qrddwebe	164	20	burden	burden	NN
cord-345472-qrddwebe	164	21	[	[	-LRB-
cord-345472-qrddwebe	164	22	114	114	CD
cord-345472-qrddwebe	164	23	]	]	-RRB-
cord-345472-qrddwebe	164	24	,	,	,
cord-345472-qrddwebe	164	25	suggesting	suggest	VBG
cord-345472-qrddwebe	164	26	that	that	IN
cord-345472-qrddwebe	164	27	neutrophil	neutrophil	NN
cord-345472-qrddwebe	164	28	heterogeneity	heterogeneity	NN
cord-345472-qrddwebe	164	29	influences	influence	VBZ
cord-345472-qrddwebe	164	30	disease	disease	NN
cord-345472-qrddwebe	164	31	outcomes	outcome	NNS
cord-345472-qrddwebe	164	32	.	.	.
cord-345472-qrddwebe	165	1	Importantly	importantly	RB
cord-345472-qrddwebe	165	2	,	,	,
cord-345472-qrddwebe	165	3	different	different	JJ
cord-345472-qrddwebe	165	4	neutrophil	neutrophil	NN
cord-345472-qrddwebe	165	5	subsets	subset	NNS
cord-345472-qrddwebe	165	6	have	have	VBP
cord-345472-qrddwebe	165	7	been	be	VBN
cord-345472-qrddwebe	165	8	identified	identify	VBN
cord-345472-qrddwebe	165	9	in	in	IN
cord-345472-qrddwebe	165	10	circulation	circulation	NN
cord-345472-qrddwebe	165	11	and	and	CC
cord-345472-qrddwebe	165	12	in	in	IN
cord-345472-qrddwebe	165	13	the	the	DT
cord-345472-qrddwebe	165	14	lung	lung	NN
cord-345472-qrddwebe	165	15	during	during	IN
cord-345472-qrddwebe	165	16	acute	acute	JJ
cord-345472-qrddwebe	165	17	RSV	rsv	NN
cord-345472-qrddwebe	165	18	-	-	HYPH
cord-345472-qrddwebe	165	19	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	165	20	[	[	-LRB-
cord-345472-qrddwebe	165	21	115	115	CD
cord-345472-qrddwebe	165	22	,	,	,
cord-345472-qrddwebe	165	23	116	116	CD
cord-345472-qrddwebe	165	24	]	]	-RRB-
cord-345472-qrddwebe	165	25	.	.	.
cord-345472-qrddwebe	166	1	Flow	flow	VB
cord-345472-qrddwebe	166	2	cytometric	cytometric	NN
cord-345472-qrddwebe	166	3	analysis	analysis	NN
cord-345472-qrddwebe	166	4	revealed	reveal	VBD
cord-345472-qrddwebe	166	5	four	four	CD
cord-345472-qrddwebe	166	6	distinct	distinct	JJ
cord-345472-qrddwebe	166	7	neutrophil	neutrophil	NN
cord-345472-qrddwebe	166	8	subsets	subset	NNS
cord-345472-qrddwebe	166	9	according	accord	VBG
cord-345472-qrddwebe	166	10	to	to	IN
cord-345472-qrddwebe	166	11	their	-PRON-	PRP$
cord-345472-qrddwebe	166	12	differential	differential	JJ
cord-345472-qrddwebe	166	13	expression	expression	NN
cord-345472-qrddwebe	166	14	of	of	IN
cord-345472-qrddwebe	166	15	CD16	CD16	NNP
cord-345472-qrddwebe	166	16	and	and	CC
cord-345472-qrddwebe	166	17	CD62L	cd62l	VB
cord-345472-qrddwebe	166	18	[	[	-LRB-
cord-345472-qrddwebe	166	19	115	115	CD
cord-345472-qrddwebe	166	20	]	]	-RRB-
cord-345472-qrddwebe	166	21	.	.	.
cord-345472-qrddwebe	167	1	These	these	DT
cord-345472-qrddwebe	167	2	included	include	VBD
cord-345472-qrddwebe	167	3	a	a	DT
cord-345472-qrddwebe	167	4	mature	mature	JJ
cord-345472-qrddwebe	167	5	subset	subset	JJ
cord-345472-qrddwebe	167	6	(	(	-LRB-
cord-345472-qrddwebe	167	7	defined	define	VBN
cord-345472-qrddwebe	167	8	as	as	IN
cord-345472-qrddwebe	167	9	CD16	CD16	NNP
cord-345472-qrddwebe	168	1	hi	hi	UH
cord-345472-qrddwebe	168	2	CD62L	cd62l	VBP
cord-345472-qrddwebe	168	3	hi	hi	UH
cord-345472-qrddwebe	168	4	)	)	-RRB-
cord-345472-qrddwebe	168	5	,	,	,
cord-345472-qrddwebe	168	6	an	an	DT
cord-345472-qrddwebe	168	7	immature	immature	JJ
cord-345472-qrddwebe	168	8	one	one	NN
cord-345472-qrddwebe	169	1	(	(	-LRB-
cord-345472-qrddwebe	169	2	CD16	CD16	NNP
cord-345472-qrddwebe	169	3	lo	lo	NNP
cord-345472-qrddwebe	169	4	CD62L	cd62l	NN
cord-345472-qrddwebe	169	5	hi	hi	NNP
cord-345472-qrddwebe	169	6	)	)	-RRB-
cord-345472-qrddwebe	169	7	,	,	,
cord-345472-qrddwebe	169	8	a	a	DT
cord-345472-qrddwebe	169	9	suppressive	suppressive	JJ
cord-345472-qrddwebe	169	10	subset	subset	NN
cord-345472-qrddwebe	169	11	(	(	-LRB-
cord-345472-qrddwebe	169	12	CD16	CD16	NNP
cord-345472-qrddwebe	169	13	hi	hi	UH
cord-345472-qrddwebe	169	14	CD62L	cd62l	VB
cord-345472-qrddwebe	169	15	lo	lo	NNP
cord-345472-qrddwebe	169	16	)	)	-RRB-
cord-345472-qrddwebe	169	17	,	,	,
cord-345472-qrddwebe	169	18	and	and	CC
cord-345472-qrddwebe	169	19	a	a	DT
cord-345472-qrddwebe	169	20	progenitor	progenitor	NN
cord-345472-qrddwebe	169	21	subset	subset	NN
cord-345472-qrddwebe	169	22	(	(	-LRB-
cord-345472-qrddwebe	169	23	CD16	CD16	NNP
cord-345472-qrddwebe	169	24	lo	lo	NNP
cord-345472-qrddwebe	169	25	CD62L	CD62L	NNP
cord-345472-qrddwebe	169	26	lo	lo	NNP
cord-345472-qrddwebe	169	27	)	)	-RRB-
cord-345472-qrddwebe	169	28	.	.	.
cord-345472-qrddwebe	170	1	The	the	DT
cord-345472-qrddwebe	170	2	relative	relative	JJ
cord-345472-qrddwebe	170	3	frequency	frequency	NN
cord-345472-qrddwebe	170	4	of	of	IN
cord-345472-qrddwebe	170	5	these	these	DT
cord-345472-qrddwebe	170	6	subsets	subset	NNS
cord-345472-qrddwebe	170	7	changed	change	VBN
cord-345472-qrddwebe	170	8	over	over	IN
cord-345472-qrddwebe	170	9	the	the	DT
cord-345472-qrddwebe	170	10	course	course	NN
cord-345472-qrddwebe	170	11	of	of	IN
cord-345472-qrddwebe	170	12	infection	infection	NN
cord-345472-qrddwebe	170	13	,	,	,
cord-345472-qrddwebe	170	14	suggesting	suggest	VBG
cord-345472-qrddwebe	170	15	that	that	IN
cord-345472-qrddwebe	170	16	they	-PRON-	PRP
cord-345472-qrddwebe	170	17	may	may	MD
cord-345472-qrddwebe	170	18	play	play	VB
cord-345472-qrddwebe	170	19	different	different	JJ
cord-345472-qrddwebe	170	20	roles	role	NNS
cord-345472-qrddwebe	170	21	,	,	,
cord-345472-qrddwebe	170	22	although	although	IN
cord-345472-qrddwebe	170	23	functional	functional	JJ
cord-345472-qrddwebe	170	24	differences	difference	NNS
cord-345472-qrddwebe	170	25	between	between	IN
cord-345472-qrddwebe	170	26	these	these	DT
cord-345472-qrddwebe	170	27	subsets	subset	NNS
cord-345472-qrddwebe	170	28	remain	remain	VBP
cord-345472-qrddwebe	170	29	to	to	TO
cord-345472-qrddwebe	170	30	be	be	VB
cord-345472-qrddwebe	170	31	shown	show	VBN
cord-345472-qrddwebe	170	32	.	.	.
cord-345472-qrddwebe	171	1	In	in	IN
cord-345472-qrddwebe	171	2	a	a	DT
cord-345472-qrddwebe	171	3	separate	separate	JJ
cord-345472-qrddwebe	171	4	study	study	NN
cord-345472-qrddwebe	171	5	in	in	IN
cord-345472-qrddwebe	171	6	RSV	RSV	NNP
cord-345472-qrddwebe	171	7	-	-	HYPH
cord-345472-qrddwebe	171	8	infected	infect	VBN
cord-345472-qrddwebe	171	9	patients	patient	NNS
cord-345472-qrddwebe	171	10	,	,	,
cord-345472-qrddwebe	171	11	Geerdink	Geerdink	NNP
cord-345472-qrddwebe	171	12	and	and	CC
cord-345472-qrddwebe	171	13	colleagues	colleague	NNS
cord-345472-qrddwebe	171	14	identified	identify	VBD
cord-345472-qrddwebe	171	15	that	that	IN
cord-345472-qrddwebe	171	16	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	171	17	in	in	IN
cord-345472-qrddwebe	171	18	BALF	BALF	NNP
cord-345472-qrddwebe	171	19	,	,	,
cord-345472-qrddwebe	171	20	compared	compare	VBN
cord-345472-qrddwebe	171	21	to	to	IN
cord-345472-qrddwebe	171	22	those	those	DT
cord-345472-qrddwebe	171	23	in	in	IN
cord-345472-qrddwebe	171	24	blood	blood	NN
cord-345472-qrddwebe	171	25	,	,	,
cord-345472-qrddwebe	171	26	displayed	display	VBD
cord-345472-qrddwebe	171	27	heightened	heightened	JJ
cord-345472-qrddwebe	171	28	expression	expression	NN
cord-345472-qrddwebe	171	29	of	of	IN
cord-345472-qrddwebe	171	30	the	the	DT
cord-345472-qrddwebe	171	31	inhibitory	inhibitory	JJ
cord-345472-qrddwebe	171	32	immune	immune	JJ
cord-345472-qrddwebe	171	33	receptor	receptor	NN
cord-345472-qrddwebe	171	34	leukocyte	leukocyte	NN
cord-345472-qrddwebe	171	35	-	-	HYPH
cord-345472-qrddwebe	171	36	associated	associate	VBN
cord-345472-qrddwebe	171	37	immunoglobulin	immunoglobulin	NN
cord-345472-qrddwebe	171	38	-	-	HYPH
cord-345472-qrddwebe	171	39	like	like	JJ
cord-345472-qrddwebe	171	40	receptor-1(LAIR-1	receptor-1(LAIR-1	NNS
cord-345472-qrddwebe	171	41	)	)	-RRB-
cord-345472-qrddwebe	171	42	[	[	-LRB-
cord-345472-qrddwebe	171	43	117	117	CD
cord-345472-qrddwebe	171	44	]	]	-RRB-
cord-345472-qrddwebe	171	45	.	.	.
cord-345472-qrddwebe	172	1	Flow	flow	NN
cord-345472-qrddwebe	172	2	cytometry	cytometry	NN
cord-345472-qrddwebe	172	3	analysis	analysis	NN
cord-345472-qrddwebe	172	4	also	also	RB
cord-345472-qrddwebe	172	5	revealed	reveal	VBD
cord-345472-qrddwebe	172	6	increased	increase	VBN
cord-345472-qrddwebe	172	7	Sirp	Sirp	NNP
cord-345472-qrddwebe	172	8	-	-	HYPH
cord-345472-qrddwebe	172	9	α	α	NNP
cord-345472-qrddwebe	172	10	,	,	,
cord-345472-qrddwebe	172	11	Siglec-9	Siglec-9	NNP
cord-345472-qrddwebe	172	12	,	,	,
cord-345472-qrddwebe	172	13	CD11b	CD11b	NNPS
cord-345472-qrddwebe	172	14	,	,	,
cord-345472-qrddwebe	172	15	and	and	CC
cord-345472-qrddwebe	172	16	reduced	reduce	VBN
cord-345472-qrddwebe	172	17	CD62L	cd62l	NN
cord-345472-qrddwebe	172	18	and	and	CC
cord-345472-qrddwebe	172	19	CD31	CD31	NNP
cord-345472-qrddwebe	172	20	expression	expression	NN
cord-345472-qrddwebe	172	21	on	on	IN
cord-345472-qrddwebe	172	22	activated	activate	VBN
cord-345472-qrddwebe	172	23	LAIR-1-expressing	lair-1-expressing	NN
cord-345472-qrddwebe	172	24	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	172	25	.	.	.
cord-345472-qrddwebe	173	1	Agonistic	agonistic	JJ
cord-345472-qrddwebe	173	2	ligation	ligation	NN
cord-345472-qrddwebe	173	3	of	of	IN
cord-345472-qrddwebe	173	4	LAIR-1	lair-1	NN
cord-345472-qrddwebe	173	5	was	be	VBD
cord-345472-qrddwebe	173	6	shown	show	VBN
cord-345472-qrddwebe	173	7	to	to	TO
cord-345472-qrddwebe	173	8	limit	limit	VB
cord-345472-qrddwebe	173	9	NET	net	JJ
cord-345472-qrddwebe	173	10	formation	formation	NN
cord-345472-qrddwebe	173	11	by	by	IN
cord-345472-qrddwebe	173	12	BALF	BALF	NNP
cord-345472-qrddwebe	173	13	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	173	14	in	in	IN
cord-345472-qrddwebe	173	15	vitro	vitro	FW
cord-345472-qrddwebe	173	16	.	.	.
cord-345472-qrddwebe	174	1	Of	of	IN
cord-345472-qrddwebe	174	2	note	note	NN
cord-345472-qrddwebe	174	3	,	,	,
cord-345472-qrddwebe	174	4	RSV	RSV	NNP
cord-345472-qrddwebe	174	5	-	-	HYPH
cord-345472-qrddwebe	174	6	infected	infect	VBN
cord-345472-qrddwebe	174	7	LAIR-1-deficient	lair-1-deficient	NN
cord-345472-qrddwebe	174	8	mice	mouse	NNS
cord-345472-qrddwebe	174	9	present	present	JJ
cord-345472-qrddwebe	174	10	with	with	IN
cord-345472-qrddwebe	174	11	greater	great	JJR
cord-345472-qrddwebe	174	12	neutrophilic	neutrophilic	JJ
cord-345472-qrddwebe	174	13	inflammation	inflammation	NN
cord-345472-qrddwebe	174	14	upon	upon	IN
cord-345472-qrddwebe	174	15	inoculation	inoculation	NN
cord-345472-qrddwebe	174	16	with	with	IN
cord-345472-qrddwebe	174	17	RSV	RSV	NNP
cord-345472-qrddwebe	174	18	[	[	-LRB-
cord-345472-qrddwebe	174	19	118	118	CD
cord-345472-qrddwebe	174	20	]	]	-RRB-
cord-345472-qrddwebe	174	21	,	,	,
cord-345472-qrddwebe	174	22	supporting	support	VBG
cord-345472-qrddwebe	174	23	the	the	DT
cord-345472-qrddwebe	174	24	notion	notion	NN
cord-345472-qrddwebe	174	25	that	that	IN
cord-345472-qrddwebe	174	26	agonism	agonism	NN
cord-345472-qrddwebe	174	27	of	of	IN
cord-345472-qrddwebe	174	28	LAIR-1	lair-1	NN
cord-345472-qrddwebe	174	29	is	be	VBZ
cord-345472-qrddwebe	174	30	a	a	DT
cord-345472-qrddwebe	174	31	logical	logical	JJ
cord-345472-qrddwebe	174	32	strategy	strategy	NN
cord-345472-qrddwebe	174	33	to	to	TO
cord-345472-qrddwebe	174	34	ameliorate	ameliorate	VB
cord-345472-qrddwebe	174	35	the	the	DT
cord-345472-qrddwebe	174	36	severity	severity	NN
cord-345472-qrddwebe	174	37	of	of	IN
cord-345472-qrddwebe	174	38	viral	viral	JJ
cord-345472-qrddwebe	174	39	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	174	40	.	.	.
cord-345472-qrddwebe	175	1	In	in	IN
cord-345472-qrddwebe	175	2	a	a	DT
cord-345472-qrddwebe	175	3	separate	separate	JJ
cord-345472-qrddwebe	175	4	study	study	NN
cord-345472-qrddwebe	175	5	performed	perform	VBN
cord-345472-qrddwebe	175	6	in	in	IN
cord-345472-qrddwebe	175	7	infants	infant	NNS
cord-345472-qrddwebe	175	8	with	with	IN
cord-345472-qrddwebe	175	9	an	an	DT
cord-345472-qrddwebe	175	10	RSV	RSV	NNP
cord-345472-qrddwebe	175	11	infection	infection	NN
cord-345472-qrddwebe	175	12	,	,	,
cord-345472-qrddwebe	175	13	the	the	DT
cord-345472-qrddwebe	175	14	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	175	15	in	in	IN
cord-345472-qrddwebe	175	16	the	the	DT
cord-345472-qrddwebe	175	17	nasopharyngeal	nasopharyngeal	JJ
cord-345472-qrddwebe	175	18	aspirates	aspirate	NNS
cord-345472-qrddwebe	175	19	were	be	VBD
cord-345472-qrddwebe	175	20	shown	show	VBN
cord-345472-qrddwebe	175	21	to	to	TO
cord-345472-qrddwebe	175	22	exhibit	exhibit	VB
cord-345472-qrddwebe	175	23	lower	low	JJR
cord-345472-qrddwebe	175	24	CD62L	cd62l	NN
cord-345472-qrddwebe	175	25	and	and	CC
cord-345472-qrddwebe	175	26	CD31	CD31	NNP
cord-345472-qrddwebe	175	27	(	(	-LRB-
cord-345472-qrddwebe	175	28	PECAM-1	PECAM-1	NNP
cord-345472-qrddwebe	175	29	)	)	-RRB-
cord-345472-qrddwebe	175	30	and	and	CC
cord-345472-qrddwebe	175	31	higher	high	JJR
cord-345472-qrddwebe	175	32	CD54	CD54	NNP
cord-345472-qrddwebe	175	33	(	(	-LRB-
cord-345472-qrddwebe	175	34	ICAM	ICAM	NNP
cord-345472-qrddwebe	175	35	-	-	HYPH
cord-345472-qrddwebe	175	36	I	I	NNP
cord-345472-qrddwebe	175	37	)	)	-RRB-
cord-345472-qrddwebe	175	38	,	,	,
cord-345472-qrddwebe	175	39	CD11b	CD11b	NNPS
cord-345472-qrddwebe	175	40	,	,	,
cord-345472-qrddwebe	175	41	and	and	CC
cord-345472-qrddwebe	175	42	CD18	CD18	NNP
cord-345472-qrddwebe	175	43	expression	expression	NN
cord-345472-qrddwebe	175	44	compared	compare	VBN
cord-345472-qrddwebe	175	45	to	to	IN
cord-345472-qrddwebe	175	46	those	those	DT
cord-345472-qrddwebe	175	47	in	in	IN
cord-345472-qrddwebe	175	48	peripheral	peripheral	JJ
cord-345472-qrddwebe	175	49	blood	blood	NN
cord-345472-qrddwebe	175	50	[	[	-LRB-
cord-345472-qrddwebe	175	51	116	116	CD
cord-345472-qrddwebe	175	52	]	]	-RRB-
cord-345472-qrddwebe	175	53	.	.	.
cord-345472-qrddwebe	176	1	CD18	CD18	NNP
cord-345472-qrddwebe	176	2	and	and	CC
cord-345472-qrddwebe	176	3	ICAM-1	icam-1	JJ
cord-345472-qrddwebe	176	4	expression	expression	NN
cord-345472-qrddwebe	176	5	on	on	IN
cord-345472-qrddwebe	176	6	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	176	7	are	be	VBP
cord-345472-qrddwebe	176	8	also	also	RB
cord-345472-qrddwebe	176	9	increased	increase	VBN
cord-345472-qrddwebe	176	10	in	in	IN
cord-345472-qrddwebe	176	11	RSV	RSV	NNP
cord-345472-qrddwebe	176	12	-	-	HYPH
cord-345472-qrddwebe	176	13	infected	infect	VBN
cord-345472-qrddwebe	176	14	infants	infant	NNS
cord-345472-qrddwebe	176	15	compared	compare	VBN
cord-345472-qrddwebe	176	16	with	with	IN
cord-345472-qrddwebe	176	17	uninfected	uninfected	JJ
cord-345472-qrddwebe	176	18	control	control	NN
cord-345472-qrddwebe	176	19	infants	infant	NNS
cord-345472-qrddwebe	176	20	[	[	-LRB-
cord-345472-qrddwebe	176	21	119	119	CD
cord-345472-qrddwebe	176	22	]	]	-RRB-
cord-345472-qrddwebe	176	23	.	.	.
cord-345472-qrddwebe	177	1	In	in	IN
cord-345472-qrddwebe	177	2	a	a	DT
cord-345472-qrddwebe	177	3	more	more	RBR
cord-345472-qrddwebe	177	4	recent	recent	JJ
cord-345472-qrddwebe	177	5	study	study	NN
cord-345472-qrddwebe	177	6	,	,	,
cord-345472-qrddwebe	177	7	the	the	DT
cord-345472-qrddwebe	177	8	addition	addition	NN
cord-345472-qrddwebe	177	9	of	of	IN
cord-345472-qrddwebe	177	10	physiological	physiological	JJ
cord-345472-qrddwebe	177	11	concentrations	concentration	NNS
cord-345472-qrddwebe	177	12	of	of	IN
cord-345472-qrddwebe	177	13	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	177	14	to	to	IN
cord-345472-qrddwebe	177	15	human	human	JJ
cord-345472-qrddwebe	177	16	RSV	RSV	NNP
cord-345472-qrddwebe	177	17	-	-	HYPH
cord-345472-qrddwebe	177	18	infected	infect	VBN
cord-345472-qrddwebe	177	19	nasal	nasal	NN
cord-345472-qrddwebe	177	20	cultures	culture	NNS
cord-345472-qrddwebe	177	21	in	in	IN
cord-345472-qrddwebe	177	22	vitro	vitro	FW
cord-345472-qrddwebe	177	23	increased	increase	VBD
cord-345472-qrddwebe	177	24	epithelial	epithelial	JJ
cord-345472-qrddwebe	177	25	cell	cell	NN
cord-345472-qrddwebe	177	26	damage	damage	NN
cord-345472-qrddwebe	177	27	,	,	,
cord-345472-qrddwebe	177	28	characterised	characterise	VBN
cord-345472-qrddwebe	177	29	by	by	IN
cord-345472-qrddwebe	177	30	lower	low	JJR
cord-345472-qrddwebe	177	31	ciliary	ciliary	NN
cord-345472-qrddwebe	177	32	activity	activity	NN
cord-345472-qrddwebe	177	33	,	,	,
cord-345472-qrddwebe	177	34	cilium	cilium	NN
cord-345472-qrddwebe	177	35	loss	loss	NN
cord-345472-qrddwebe	177	36	,	,	,
cord-345472-qrddwebe	177	37	less	less	RBR
cord-345472-qrddwebe	177	38	tight	tight	JJ
cord-345472-qrddwebe	177	39	junction	junction	NN
cord-345472-qrddwebe	177	40	expression	expression	NN
cord-345472-qrddwebe	177	41	,	,	,
cord-345472-qrddwebe	177	42	and	and	CC
cord-345472-qrddwebe	177	43	greater	great	JJR
cord-345472-qrddwebe	177	44	detachment	detachment	NN
cord-345472-qrddwebe	177	45	of	of	IN
cord-345472-qrddwebe	177	46	epithelial	epithelial	JJ
cord-345472-qrddwebe	177	47	cells	cell	NNS
cord-345472-qrddwebe	177	48	,	,	,
cord-345472-qrddwebe	177	49	compared	compare	VBN
cord-345472-qrddwebe	177	50	to	to	IN
cord-345472-qrddwebe	177	51	cultures	culture	NNS
cord-345472-qrddwebe	177	52	with	with	IN
cord-345472-qrddwebe	177	53	RSV	RSV	NNP
cord-345472-qrddwebe	177	54	-	-	HYPH
cord-345472-qrddwebe	177	55	infected	infect	VBN
cord-345472-qrddwebe	177	56	epithelial	epithelial	JJ
cord-345472-qrddwebe	177	57	cells	cell	NNS
cord-345472-qrddwebe	177	58	alone	alone	RB
cord-345472-qrddwebe	177	59	[	[	-LRB-
cord-345472-qrddwebe	177	60	120	120	CD
cord-345472-qrddwebe	177	61	]	]	-RRB-
cord-345472-qrddwebe	177	62	.	.	.
cord-345472-qrddwebe	178	1	High	high	JJ
cord-345472-qrddwebe	178	2	-	-	HYPH
cord-345472-qrddwebe	178	3	throughput	throughput	NN
cord-345472-qrddwebe	178	4	analysis	analysis	NN
cord-345472-qrddwebe	178	5	of	of	IN
cord-345472-qrddwebe	178	6	lung	lung	NN
cord-345472-qrddwebe	178	7	-	-	HYPH
cord-345472-qrddwebe	178	8	infiltrating	infiltrate	VBG
cord-345472-qrddwebe	178	9	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	178	10	using	use	VBG
cord-345472-qrddwebe	178	11	the	the	DT
cord-345472-qrddwebe	178	12	latest	late	JJS
cord-345472-qrddwebe	178	13	transcriptomic	transcriptomic	JJ
cord-345472-qrddwebe	178	14	and	and	CC
cord-345472-qrddwebe	178	15	high	high	JJ
cord-345472-qrddwebe	178	16	-	-	HYPH
cord-345472-qrddwebe	178	17	dimensional	dimensional	JJ
cord-345472-qrddwebe	178	18	flow	flow	NN
cord-345472-qrddwebe	178	19	cytometry	cytometry	NN
cord-345472-qrddwebe	178	20	is	be	VBZ
cord-345472-qrddwebe	178	21	now	now	RB
cord-345472-qrddwebe	178	22	needed	need	VBN
cord-345472-qrddwebe	178	23	to	to	TO
cord-345472-qrddwebe	178	24	better	better	RB
cord-345472-qrddwebe	178	25	identify	identify	VB
cord-345472-qrddwebe	178	26	different	different	JJ
cord-345472-qrddwebe	178	27	neutrophil	neutrophil	NN
cord-345472-qrddwebe	178	28	subsets	subset	NNS
cord-345472-qrddwebe	178	29	and	and	CC
cord-345472-qrddwebe	178	30	associate	associate	VB
cord-345472-qrddwebe	178	31	these	these	DT
cord-345472-qrddwebe	178	32	with	with	IN
cord-345472-qrddwebe	178	33	beneficial	beneficial	JJ
cord-345472-qrddwebe	178	34	and	and	CC
cord-345472-qrddwebe	178	35	deleterious	deleterious	JJ
cord-345472-qrddwebe	178	36	outcomes	outcome	NNS
cord-345472-qrddwebe	178	37	.	.	.
cord-345472-qrddwebe	179	1	Such	such	JJ
cord-345472-qrddwebe	179	2	knowledge	knowledge	NN
cord-345472-qrddwebe	179	3	,	,	,
cord-345472-qrddwebe	179	4	together	together	RB
cord-345472-qrddwebe	179	5	with	with	IN
cord-345472-qrddwebe	179	6	an	an	DT
cord-345472-qrddwebe	179	7	understanding	understanding	NN
cord-345472-qrddwebe	179	8	of	of	IN
cord-345472-qrddwebe	179	9	the	the	DT
cord-345472-qrddwebe	179	10	molecular	molecular	JJ
cord-345472-qrddwebe	179	11	signals	signal	NNS
cord-345472-qrddwebe	179	12	controlling	control	VBG
cord-345472-qrddwebe	179	13	neutrophil	neutrophil	NN
cord-345472-qrddwebe	179	14	recruitment	recruitment	NN
cord-345472-qrddwebe	179	15	and	and	CC
cord-345472-qrddwebe	179	16	function	function	NN
cord-345472-qrddwebe	179	17	,	,	,
cord-345472-qrddwebe	179	18	is	be	VBZ
cord-345472-qrddwebe	179	19	likely	likely	JJ
cord-345472-qrddwebe	179	20	to	to	TO
cord-345472-qrddwebe	179	21	reveal	reveal	VB
cord-345472-qrddwebe	179	22	novel	novel	JJ
cord-345472-qrddwebe	179	23	prognostic	prognostic	JJ
cord-345472-qrddwebe	179	24	biomarkers	biomarker	NNS
cord-345472-qrddwebe	179	25	and	and	CC
cord-345472-qrddwebe	179	26	targets	target	NNS
cord-345472-qrddwebe	179	27	for	for	IN
cord-345472-qrddwebe	179	28	therapeutic	therapeutic	JJ
cord-345472-qrddwebe	179	29	intervention	intervention	NN
cord-345472-qrddwebe	179	30	.	.	.
cord-345472-qrddwebe	180	1	Neutropenic	neutropenic	JJ
cord-345472-qrddwebe	180	2	individuals	individual	NNS
cord-345472-qrddwebe	180	3	are	be	VBP
cord-345472-qrddwebe	180	4	highly	highly	RB
cord-345472-qrddwebe	180	5	susceptible	susceptible	JJ
cord-345472-qrddwebe	180	6	to	to	IN
cord-345472-qrddwebe	180	7	bacterial	bacterial	JJ
cord-345472-qrddwebe	180	8	and	and	CC
cord-345472-qrddwebe	180	9	fungal	fungal	JJ
cord-345472-qrddwebe	180	10	infections	infection	NNS
cord-345472-qrddwebe	180	11	.	.	.
cord-345472-qrddwebe	181	1	The	the	DT
cord-345472-qrddwebe	181	2	evidence	evidence	NN
cord-345472-qrddwebe	181	3	with	with	IN
cord-345472-qrddwebe	181	4	regard	regard	NN
cord-345472-qrddwebe	181	5	to	to	IN
cord-345472-qrddwebe	181	6	viral	viral	JJ
cord-345472-qrddwebe	181	7	infections	infection	NNS
cord-345472-qrddwebe	181	8	is	be	VBZ
cord-345472-qrddwebe	181	9	less	less	RBR
cord-345472-qrddwebe	181	10	clear	clear	JJ
cord-345472-qrddwebe	181	11	[	[	-LRB-
cord-345472-qrddwebe	181	12	18	18	CD
cord-345472-qrddwebe	181	13	]	]	-RRB-
cord-345472-qrddwebe	181	14	,	,	,
cord-345472-qrddwebe	181	15	suggesting	suggest	VBG
cord-345472-qrddwebe	181	16	that	that	IN
cord-345472-qrddwebe	181	17	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	181	18	are	be	VBP
cord-345472-qrddwebe	181	19	not	not	RB
cord-345472-qrddwebe	181	20	critical	critical	JJ
cord-345472-qrddwebe	181	21	participants	participant	NNS
cord-345472-qrddwebe	181	22	.	.	.
cord-345472-qrddwebe	182	1	However	however	RB
cord-345472-qrddwebe	182	2	,	,	,
cord-345472-qrddwebe	182	3	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	182	4	do	do	VBP
cord-345472-qrddwebe	182	5	appear	appear	VB
cord-345472-qrddwebe	182	6	to	to	TO
cord-345472-qrddwebe	182	7	be	be	VB
cord-345472-qrddwebe	182	8	required	require	VBN
cord-345472-qrddwebe	182	9	for	for	IN
cord-345472-qrddwebe	182	10	optimal	optimal	JJ
cord-345472-qrddwebe	182	11	host	host	NN
cord-345472-qrddwebe	182	12	immunity	immunity	NN
cord-345472-qrddwebe	182	13	against	against	IN
cord-345472-qrddwebe	182	14	an	an	DT
cord-345472-qrddwebe	182	15	RSV	RSV	NNP
cord-345472-qrddwebe	182	16	infection	infection	NN
cord-345472-qrddwebe	182	17	.	.	.
cord-345472-qrddwebe	183	1	To	to	TO
cord-345472-qrddwebe	183	2	accomplish	accomplish	VB
cord-345472-qrddwebe	183	3	this	this	DT
cord-345472-qrddwebe	183	4	,	,	,
cord-345472-qrddwebe	183	5	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	183	6	detect	detect	VBP
cord-345472-qrddwebe	183	7	virus	virus	NN
cord-345472-qrddwebe	183	8	-	-	HYPH
cord-345472-qrddwebe	183	9	associated	associate	VBN
cord-345472-qrddwebe	183	10	molecular	molecular	JJ
cord-345472-qrddwebe	183	11	patterns	pattern	NNS
cord-345472-qrddwebe	183	12	through	through	IN
cord-345472-qrddwebe	183	13	pattern	pattern	NN
cord-345472-qrddwebe	183	14	recognition	recognition	NN
cord-345472-qrddwebe	183	15	receptors	receptor	NNS
cord-345472-qrddwebe	183	16	(	(	-LRB-
cord-345472-qrddwebe	183	17	such	such	JJ
cord-345472-qrddwebe	183	18	as	as	IN
cord-345472-qrddwebe	183	19	TLRs	TLRs	NNP
cord-345472-qrddwebe	183	20	)	)	-RRB-
cord-345472-qrddwebe	183	21	,	,	,
cord-345472-qrddwebe	183	22	produce	produce	VBP
cord-345472-qrddwebe	183	23	an	an	DT
cord-345472-qrddwebe	183	24	array	array	NN
cord-345472-qrddwebe	183	25	of	of	IN
cord-345472-qrddwebe	183	26	antimicrobial	antimicrobial	JJ
cord-345472-qrddwebe	183	27	products	product	NNS
cord-345472-qrddwebe	183	28	,	,	,
cord-345472-qrddwebe	183	29	and	and	CC
cord-345472-qrddwebe	183	30	assist	assist	VB
cord-345472-qrddwebe	183	31	the	the	DT
cord-345472-qrddwebe	183	32	adaptive	adaptive	JJ
cord-345472-qrddwebe	183	33	immune	immune	JJ
cord-345472-qrddwebe	183	34	responses	response	NNS
cord-345472-qrddwebe	183	35	.	.	.
cord-345472-qrddwebe	184	1	For	for	IN
cord-345472-qrddwebe	184	2	example	example	NN
cord-345472-qrddwebe	184	3	,	,	,
cord-345472-qrddwebe	184	4	TLR4	TLR4	NNP
cord-345472-qrddwebe	184	5	expression	expression	NN
cord-345472-qrddwebe	184	6	on	on	IN
cord-345472-qrddwebe	184	7	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	184	8	is	be	VBZ
cord-345472-qrddwebe	184	9	important	important	JJ
cord-345472-qrddwebe	184	10	for	for	IN
cord-345472-qrddwebe	184	11	generating	generate	VBG
cord-345472-qrddwebe	184	12	optimal	optimal	JJ
cord-345472-qrddwebe	184	13	immunity	immunity	NN
cord-345472-qrddwebe	184	14	against	against	IN
cord-345472-qrddwebe	184	15	RSV	RSV	NNP
cord-345472-qrddwebe	184	16	infection	infection	NN
cord-345472-qrddwebe	184	17	[	[	-LRB-
cord-345472-qrddwebe	184	18	121	121	CD
cord-345472-qrddwebe	184	19	,	,	,
cord-345472-qrddwebe	184	20	122	122	CD
cord-345472-qrddwebe	184	21	]	]	-RRB-
cord-345472-qrddwebe	184	22	.	.	.
cord-345472-qrddwebe	185	1	The	the	DT
cord-345472-qrddwebe	185	2	expression	expression	NN
cord-345472-qrddwebe	185	3	of	of	IN
cord-345472-qrddwebe	185	4	TLR4	TLR4	NNP
cord-345472-qrddwebe	185	5	is	be	VBZ
cord-345472-qrddwebe	185	6	lower	low	JJR
cord-345472-qrddwebe	185	7	on	on	IN
cord-345472-qrddwebe	185	8	blood	blood	NN
cord-345472-qrddwebe	185	9	and	and	CC
cord-345472-qrddwebe	185	10	airway	airway	NN
cord-345472-qrddwebe	185	11	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	185	12	of	of	IN
cord-345472-qrddwebe	185	13	infants	infant	NNS
cord-345472-qrddwebe	185	14	with	with	IN
cord-345472-qrddwebe	185	15	severe	severe	JJ
cord-345472-qrddwebe	185	16	RSV	RSV	NNP
cord-345472-qrddwebe	185	17	infection	infection	NN
cord-345472-qrddwebe	185	18	compared	compare	VBN
cord-345472-qrddwebe	185	19	with	with	IN
cord-345472-qrddwebe	185	20	uninfected	uninfected	JJ
cord-345472-qrddwebe	185	21	controls	control	NNS
cord-345472-qrddwebe	185	22	[	[	-LRB-
cord-345472-qrddwebe	185	23	122	122	CD
cord-345472-qrddwebe	185	24	]	]	-RRB-
cord-345472-qrddwebe	185	25	.	.	.
cord-345472-qrddwebe	186	1	In	in	IN
cord-345472-qrddwebe	186	2	humans	human	NNS
cord-345472-qrddwebe	186	3	,	,	,
cord-345472-qrddwebe	186	4	two	two	CD
cord-345472-qrddwebe	186	5	TLR4	TLR4	NNP
cord-345472-qrddwebe	186	6	gene	gene	NN
cord-345472-qrddwebe	186	7	mutations	mutation	NNS
cord-345472-qrddwebe	186	8	are	be	VBP
cord-345472-qrddwebe	186	9	associated	associate	VBN
cord-345472-qrddwebe	186	10	with	with	IN
cord-345472-qrddwebe	186	11	an	an	DT
cord-345472-qrddwebe	186	12	increased	increase	VBN
cord-345472-qrddwebe	186	13	risk	risk	NN
cord-345472-qrddwebe	186	14	of	of	IN
cord-345472-qrddwebe	186	15	developing	develop	VBG
cord-345472-qrddwebe	186	16	severe	severe	JJ
cord-345472-qrddwebe	186	17	RSV	RSV	NNP
cord-345472-qrddwebe	186	18	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	186	19	[	[	-LRB-
cord-345472-qrddwebe	186	20	123	123	CD
cord-345472-qrddwebe	186	21	]	]	-RRB-
cord-345472-qrddwebe	186	22	.	.	.
cord-345472-qrddwebe	187	1	Of	of	IN
cord-345472-qrddwebe	187	2	note	note	NN
cord-345472-qrddwebe	187	3	,	,	,
cord-345472-qrddwebe	187	4	the	the	DT
cord-345472-qrddwebe	187	5	beneficial	beneficial	JJ
cord-345472-qrddwebe	187	6	or	or	CC
cord-345472-qrddwebe	187	7	detrimental	detrimental	JJ
cord-345472-qrddwebe	187	8	roles	role	NNS
cord-345472-qrddwebe	187	9	of	of	IN
cord-345472-qrddwebe	187	10	TLR	tlr	NN
cord-345472-qrddwebe	187	11	-	-	HYPH
cord-345472-qrddwebe	187	12	signalling	signal	VBG
cord-345472-qrddwebe	187	13	in	in	IN
cord-345472-qrddwebe	187	14	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	187	15	during	during	IN
cord-345472-qrddwebe	187	16	respiratory	respiratory	JJ
cord-345472-qrddwebe	187	17	viral	viral	JJ
cord-345472-qrddwebe	187	18	infections	infection	NNS
cord-345472-qrddwebe	187	19	may	may	MD
cord-345472-qrddwebe	187	20	be	be	VB
cord-345472-qrddwebe	187	21	context	context	NN
cord-345472-qrddwebe	187	22	-	-	HYPH
cord-345472-qrddwebe	187	23	dependent	dependent	JJ
cord-345472-qrddwebe	187	24	.	.	.
cord-345472-qrddwebe	188	1	For	for	IN
cord-345472-qrddwebe	188	2	instance	instance	NN
cord-345472-qrddwebe	188	3	,	,	,
cord-345472-qrddwebe	188	4	TLR4-signalling	TLR4-signalling	NNP
cord-345472-qrddwebe	188	5	may	may	MD
cord-345472-qrddwebe	188	6	be	be	VB
cord-345472-qrddwebe	188	7	detrimental	detrimental	JJ
cord-345472-qrddwebe	188	8	in	in	IN
cord-345472-qrddwebe	188	9	RSV	RSV	NNP
cord-345472-qrddwebe	188	10	infection	infection	NN
cord-345472-qrddwebe	188	11	but	but	CC
cord-345472-qrddwebe	188	12	protective	protective	JJ
cord-345472-qrddwebe	188	13	against	against	IN
cord-345472-qrddwebe	188	14	influenza	influenza	NN
cord-345472-qrddwebe	188	15	.	.	.
cord-345472-qrddwebe	189	1	Therapeutic	therapeutic	JJ
cord-345472-qrddwebe	189	2	TLR4	TLR4	NNP
cord-345472-qrddwebe	189	3	antagonism	antagonism	NN
cord-345472-qrddwebe	189	4	lowers	lower	VBZ
cord-345472-qrddwebe	189	5	TNF	TNF	NNP
cord-345472-qrddwebe	189	6	-	-	HYPH
cord-345472-qrddwebe	189	7	α	α	NNP
cord-345472-qrddwebe	189	8	,	,	,
cord-345472-qrddwebe	189	9	IL-1α	IL-1α	NNP
cord-345472-qrddwebe	189	10	,	,	,
cord-345472-qrddwebe	189	11	Ptgs2	Ptgs2	NNP
cord-345472-qrddwebe	189	12	,	,	,
cord-345472-qrddwebe	189	13	and	and	CC
cord-345472-qrddwebe	189	14	Cxcl1	cxcl1	JJ
cord-345472-qrddwebe	189	15	gene	gene	NN
cord-345472-qrddwebe	189	16	expression	expression	NN
cord-345472-qrddwebe	189	17	and	and	CC
cord-345472-qrddwebe	189	18	improves	improve	VBZ
cord-345472-qrddwebe	189	19	survival	survival	NN
cord-345472-qrddwebe	189	20	of	of	IN
cord-345472-qrddwebe	189	21	mice	mouse	NNS
cord-345472-qrddwebe	189	22	infected	infect	VBN
cord-345472-qrddwebe	189	23	with	with	IN
cord-345472-qrddwebe	189	24	a	a	DT
cord-345472-qrddwebe	189	25	lethal	lethal	JJ
cord-345472-qrddwebe	189	26	dose	dose	NN
cord-345472-qrddwebe	189	27	of	of	IN
cord-345472-qrddwebe	189	28	influenza	influenza	NN
cord-345472-qrddwebe	189	29	A	a	NN
cord-345472-qrddwebe	189	30	[	[	-LRB-
cord-345472-qrddwebe	189	31	124	124	CD
cord-345472-qrddwebe	189	32	]	]	-RRB-
cord-345472-qrddwebe	189	33	.	.	.
cord-345472-qrddwebe	190	1	Some	some	DT
cord-345472-qrddwebe	190	2	neutrophil	neutrophil	NN
cord-345472-qrddwebe	190	3	anti	anti	JJ
cord-345472-qrddwebe	190	4	-	-	JJ
cord-345472-qrddwebe	190	5	microbial	microbial	JJ
cord-345472-qrddwebe	190	6	products	product	NNS
cord-345472-qrddwebe	190	7	may	may	MD
cord-345472-qrddwebe	190	8	be	be	VB
cord-345472-qrddwebe	190	9	exploited	exploit	VBN
cord-345472-qrddwebe	190	10	for	for	IN
cord-345472-qrddwebe	190	11	boosting	boost	VBG
cord-345472-qrddwebe	190	12	anti	anti	JJ
cord-345472-qrddwebe	190	13	-	-	JJ
cord-345472-qrddwebe	190	14	viral	viral	JJ
cord-345472-qrddwebe	190	15	immunity	immunity	NN
cord-345472-qrddwebe	190	16	during	during	IN
cord-345472-qrddwebe	190	17	RSV	RSV	NNP
cord-345472-qrddwebe	190	18	infection	infection	NN
cord-345472-qrddwebe	190	19	.	.	.
cord-345472-qrddwebe	191	1	For	for	IN
cord-345472-qrddwebe	191	2	instance	instance	NN
cord-345472-qrddwebe	191	3	,	,	,
cord-345472-qrddwebe	191	4	inflammatory	inflammatory	JJ
cord-345472-qrddwebe	191	5	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	191	6	produce	produce	VBP
cord-345472-qrddwebe	191	7	cathelicidins	cathelicidin	NNS
cord-345472-qrddwebe	191	8	;	;	:
cord-345472-qrddwebe	191	9	cationic	cationic	JJ
cord-345472-qrddwebe	191	10	proteins	protein	NNS
cord-345472-qrddwebe	191	11	important	important	JJ
cord-345472-qrddwebe	191	12	for	for	IN
cord-345472-qrddwebe	191	13	host	host	NN
cord-345472-qrddwebe	191	14	defence	defence	NN
cord-345472-qrddwebe	191	15	.	.	.
cord-345472-qrddwebe	192	1	Intriguingly	intriguingly	RB
cord-345472-qrddwebe	192	2	,	,	,
cord-345472-qrddwebe	192	3	in	in	IN
cord-345472-qrddwebe	192	4	infants	infant	NNS
cord-345472-qrddwebe	192	5	hospitalised	hospitalise	VBN
cord-345472-qrddwebe	192	6	with	with	IN
cord-345472-qrddwebe	192	7	viral	viral	JJ
cord-345472-qrddwebe	192	8	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	192	9	,	,	,
cord-345472-qrddwebe	192	10	those	those	DT
cord-345472-qrddwebe	192	11	with	with	IN
cord-345472-qrddwebe	192	12	the	the	DT
cord-345472-qrddwebe	192	13	lowest	low	JJS
cord-345472-qrddwebe	192	14	levels	level	NNS
cord-345472-qrddwebe	192	15	of	of	IN
cord-345472-qrddwebe	192	16	LL-37	LL-37	NNP
cord-345472-qrddwebe	192	17	were	be	VBD
cord-345472-qrddwebe	192	18	more	more	RBR
cord-345472-qrddwebe	192	19	likely	likely	JJ
cord-345472-qrddwebe	192	20	to	to	TO
cord-345472-qrddwebe	192	21	be	be	VB
cord-345472-qrddwebe	192	22	infected	infect	VBN
cord-345472-qrddwebe	192	23	with	with	IN
cord-345472-qrddwebe	192	24	RSV	RSV	NNP
cord-345472-qrddwebe	192	25	,	,	,
cord-345472-qrddwebe	192	26	suggesting	suggest	VBG
cord-345472-qrddwebe	192	27	that	that	IN
cord-345472-qrddwebe	192	28	LL-37	LL-37	NNP
cord-345472-qrddwebe	192	29	is	be	VBZ
cord-345472-qrddwebe	192	30	beneficial	beneficial	JJ
cord-345472-qrddwebe	192	31	[	[	-LRB-
cord-345472-qrddwebe	192	32	125	125	CD
cord-345472-qrddwebe	192	33	]	]	-RRB-
cord-345472-qrddwebe	192	34	.	.	.
cord-345472-qrddwebe	193	1	Human	human	JJ
cord-345472-qrddwebe	193	2	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	193	3	stimulated	stimulate	VBN
cord-345472-qrddwebe	193	4	in	in	IN
cord-345472-qrddwebe	193	5	vitro	vitro	FW
cord-345472-qrddwebe	193	6	with	with	IN
cord-345472-qrddwebe	193	7	RSV	RSV	NNP
cord-345472-qrddwebe	193	8	virions	virion	NNS
cord-345472-qrddwebe	193	9	secrete	secrete	VBP
cord-345472-qrddwebe	193	10	LL-37	LL-37	NNP
cord-345472-qrddwebe	193	11	,	,	,
cord-345472-qrddwebe	193	12	inhibiting	inhibit	VBG
cord-345472-qrddwebe	193	13	the	the	DT
cord-345472-qrddwebe	193	14	formation	formation	NN
cord-345472-qrddwebe	193	15	of	of	IN
cord-345472-qrddwebe	193	16	new	new	JJ
cord-345472-qrddwebe	193	17	viral	viral	JJ
cord-345472-qrddwebe	193	18	particles	particle	NNS
cord-345472-qrddwebe	193	19	and	and	CC
cord-345472-qrddwebe	193	20	reducing	reduce	VBG
cord-345472-qrddwebe	193	21	the	the	DT
cord-345472-qrddwebe	193	22	apoptosis	apoptosis	NN
cord-345472-qrddwebe	193	23	of	of	IN
cord-345472-qrddwebe	193	24	infected	infected	JJ
cord-345472-qrddwebe	193	25	epithelial	epithelial	JJ
cord-345472-qrddwebe	193	26	cells	cell	NNS
cord-345472-qrddwebe	193	27	[	[	-LRB-
cord-345472-qrddwebe	193	28	126	126	CD
cord-345472-qrddwebe	193	29	,	,	,
cord-345472-qrddwebe	193	30	127	127	CD
cord-345472-qrddwebe	193	31	]	]	-RRB-
cord-345472-qrddwebe	193	32	.	.	.
cord-345472-qrddwebe	194	1	Neutrophil	Neutrophil	NNP
cord-345472-qrddwebe	194	2	-	-	HYPH
cord-345472-qrddwebe	194	3	derived	derive	VBN
cord-345472-qrddwebe	194	4	LL-37	LL-37	NNP
cord-345472-qrddwebe	194	5	may	may	MD
cord-345472-qrddwebe	194	6	support	support	VB
cord-345472-qrddwebe	194	7	the	the	DT
cord-345472-qrddwebe	194	8	production	production	NN
cord-345472-qrddwebe	194	9	of	of	IN
cord-345472-qrddwebe	194	10	interferons	interferon	NNS
cord-345472-qrddwebe	194	11	,	,	,
cord-345472-qrddwebe	194	12	which	which	WDT
cord-345472-qrddwebe	194	13	are	be	VBP
cord-345472-qrddwebe	194	14	required	require	VBN
cord-345472-qrddwebe	194	15	for	for	IN
cord-345472-qrddwebe	194	16	viral	viral	JJ
cord-345472-qrddwebe	194	17	control	control	NN
cord-345472-qrddwebe	194	18	.	.	.
cord-345472-qrddwebe	195	1	In	in	IN
cord-345472-qrddwebe	195	2	mice	mouse	NNS
cord-345472-qrddwebe	195	3	,	,	,
cord-345472-qrddwebe	195	4	treatment	treatment	NN
cord-345472-qrddwebe	195	5	with	with	IN
cord-345472-qrddwebe	195	6	an	an	DT
cord-345472-qrddwebe	195	7	exogenous	exogenous	JJ
cord-345472-qrddwebe	195	8	LL-37	LL-37	NNP
cord-345472-qrddwebe	195	9	peptide	peptide	NN
cord-345472-qrddwebe	195	10	protected	protect	VBN
cord-345472-qrddwebe	195	11	against	against	IN
cord-345472-qrddwebe	195	12	body	body	NN
cord-345472-qrddwebe	195	13	weight	weight	NN
cord-345472-qrddwebe	195	14	loss	loss	NN
cord-345472-qrddwebe	195	15	,	,	,
cord-345472-qrddwebe	195	16	increased	increase	VBN
cord-345472-qrddwebe	195	17	interferon	interferon	NN
cord-345472-qrddwebe	195	18	-	-	HYPH
cord-345472-qrddwebe	195	19	lambda	lambda	NN
cord-345472-qrddwebe	195	20	production	production	NN
cord-345472-qrddwebe	195	21	,	,	,
cord-345472-qrddwebe	195	22	and	and	CC
cord-345472-qrddwebe	195	23	lowered	lower	VBD
cord-345472-qrddwebe	195	24	RSV	RSV	NNP
cord-345472-qrddwebe	195	25	load	load	NN
cord-345472-qrddwebe	195	26	[	[	-LRB-
cord-345472-qrddwebe	195	27	128	128	CD
cord-345472-qrddwebe	195	28	]	]	-RRB-
cord-345472-qrddwebe	195	29	.	.	.
cord-345472-qrddwebe	196	1	Neutrophils	neutrophils	NN
cord-345472-qrddwebe	196	2	may	may	MD
cord-345472-qrddwebe	196	3	also	also	RB
cord-345472-qrddwebe	196	4	influence	influence	VB
cord-345472-qrddwebe	196	5	the	the	DT
cord-345472-qrddwebe	196	6	quality	quality	NN
cord-345472-qrddwebe	196	7	of	of	IN
cord-345472-qrddwebe	196	8	adaptive	adaptive	JJ
cord-345472-qrddwebe	196	9	immune	immune	JJ
cord-345472-qrddwebe	196	10	responses	response	NNS
cord-345472-qrddwebe	196	11	that	that	WDT
cord-345472-qrddwebe	196	12	develop	develop	VBP
cord-345472-qrddwebe	196	13	during	during	IN
cord-345472-qrddwebe	196	14	RSV	RSV	NNP
cord-345472-qrddwebe	196	15	infection	infection	NN
cord-345472-qrddwebe	196	16	.	.	.
cord-345472-qrddwebe	197	1	For	for	IN
cord-345472-qrddwebe	197	2	example	example	NN
cord-345472-qrddwebe	197	3	,	,	,
cord-345472-qrddwebe	197	4	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	197	5	may	may	MD
cord-345472-qrddwebe	197	6	aid	aid	VB
cord-345472-qrddwebe	197	7	in	in	IN
cord-345472-qrddwebe	197	8	the	the	DT
cord-345472-qrddwebe	197	9	rapid	rapid	JJ
cord-345472-qrddwebe	197	10	recruitment	recruitment	NN
cord-345472-qrddwebe	197	11	of	of	IN
cord-345472-qrddwebe	197	12	virus	virus	NN
cord-345472-qrddwebe	197	13	-	-	HYPH
cord-345472-qrddwebe	197	14	specific	specific	JJ
cord-345472-qrddwebe	197	15	CD8	CD8	NNP
cord-345472-qrddwebe	197	16	+	+	CC
cord-345472-qrddwebe	197	17	T	t	NN
cord-345472-qrddwebe	197	18	-	-	HYPH
cord-345472-qrddwebe	197	19	cells	cell	NNS
cord-345472-qrddwebe	197	20	.	.	.
cord-345472-qrddwebe	198	1	In	in	IN
cord-345472-qrddwebe	198	2	infants	infant	NNS
cord-345472-qrddwebe	198	3	with	with	IN
cord-345472-qrddwebe	198	4	RSV	RSV	NNP
cord-345472-qrddwebe	198	5	infection	infection	NN
cord-345472-qrddwebe	198	6	,	,	,
cord-345472-qrddwebe	198	7	a	a	DT
cord-345472-qrddwebe	198	8	systemic	systemic	JJ
cord-345472-qrddwebe	198	9	influx	influx	NN
cord-345472-qrddwebe	198	10	of	of	IN
cord-345472-qrddwebe	198	11	bone	bone	NN
cord-345472-qrddwebe	198	12	marrow	marrow	NN
cord-345472-qrddwebe	198	13	-	-	HYPH
cord-345472-qrddwebe	198	14	derived	derive	VBN
cord-345472-qrddwebe	198	15	neutrophil	neutrophil	NN
cord-345472-qrddwebe	198	16	precursors	precursor	NNS
cord-345472-qrddwebe	198	17	in	in	IN
cord-345472-qrddwebe	198	18	blood	blood	NN
cord-345472-qrddwebe	198	19	precedes	precede	VBZ
cord-345472-qrddwebe	198	20	robust	robust	JJ
cord-345472-qrddwebe	198	21	CD8	CD8	NNP
cord-345472-qrddwebe	198	22	+	+	CC
cord-345472-qrddwebe	198	23	T	t	NN
cord-345472-qrddwebe	198	24	-	-	HYPH
cord-345472-qrddwebe	198	25	cell	cell	NN
cord-345472-qrddwebe	198	26	activation	activation	NN
cord-345472-qrddwebe	198	27	and	and	CC
cord-345472-qrddwebe	198	28	a	a	DT
cord-345472-qrddwebe	198	29	reduction	reduction	NN
cord-345472-qrddwebe	198	30	in	in	IN
cord-345472-qrddwebe	198	31	severe	severe	JJ
cord-345472-qrddwebe	198	32	disease	disease	NN
cord-345472-qrddwebe	198	33	symptoms	symptom	NNS
cord-345472-qrddwebe	198	34	[	[	-LRB-
cord-345472-qrddwebe	198	35	129	129	CD
cord-345472-qrddwebe	198	36	]	]	-RRB-
cord-345472-qrddwebe	198	37	.	.	.
cord-345472-qrddwebe	199	1	However	however	RB
cord-345472-qrddwebe	199	2	,	,	,
cord-345472-qrddwebe	199	3	the	the	DT
cord-345472-qrddwebe	199	4	precise	precise	JJ
cord-345472-qrddwebe	199	5	mechanisms	mechanism	NNS
cord-345472-qrddwebe	199	6	through	through	IN
cord-345472-qrddwebe	199	7	which	which	WDT
cord-345472-qrddwebe	199	8	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	199	9	influence	influence	NN
cord-345472-qrddwebe	199	10	CD8	CD8	NNP
cord-345472-qrddwebe	199	11	+	+	CC
cord-345472-qrddwebe	199	12	T	T	NNP
cord-345472-qrddwebe	199	13	-	-	HYPH
cord-345472-qrddwebe	199	14	cells	cell	NNS
cord-345472-qrddwebe	199	15	remain	remain	VBP
cord-345472-qrddwebe	199	16	unclear	unclear	JJ
cord-345472-qrddwebe	199	17	.	.	.
cord-345472-qrddwebe	200	1	Collectively	collectively	RB
cord-345472-qrddwebe	200	2	,	,	,
cord-345472-qrddwebe	200	3	these	these	DT
cord-345472-qrddwebe	200	4	studies	study	NNS
cord-345472-qrddwebe	200	5	suggest	suggest	VBP
cord-345472-qrddwebe	200	6	that	that	IN
cord-345472-qrddwebe	200	7	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	200	8	can	can	MD
cord-345472-qrddwebe	200	9	act	act	VB
cord-345472-qrddwebe	200	10	beneficially	beneficially	RB
cord-345472-qrddwebe	200	11	in	in	IN
cord-345472-qrddwebe	200	12	mediating	mediate	VBG
cord-345472-qrddwebe	200	13	immune	immune	JJ
cord-345472-qrddwebe	200	14	protection	protection	NN
cord-345472-qrddwebe	200	15	against	against	IN
cord-345472-qrddwebe	200	16	RSV	RSV	NNP
cord-345472-qrddwebe	200	17	infection	infection	NN
cord-345472-qrddwebe	200	18	.	.	.
cord-345472-qrddwebe	201	1	However	however	RB
cord-345472-qrddwebe	201	2	,	,	,
cord-345472-qrddwebe	201	3	perturbation	perturbation	NN
cord-345472-qrddwebe	201	4	of	of	IN
cord-345472-qrddwebe	201	5	optimal	optimal	JJ
cord-345472-qrddwebe	201	6	neutrophil	neutrophil	NN
cord-345472-qrddwebe	201	7	function	function	NN
cord-345472-qrddwebe	201	8	during	during	IN
cord-345472-qrddwebe	201	9	infection	infection	NN
cord-345472-qrddwebe	201	10	may	may	MD
cord-345472-qrddwebe	201	11	amplify	amplify	VB
cord-345472-qrddwebe	201	12	their	-PRON-	PRP$
cord-345472-qrddwebe	201	13	effector	effector	NN
cord-345472-qrddwebe	201	14	responses	response	NNS
cord-345472-qrddwebe	201	15	and	and	CC
cord-345472-qrddwebe	201	16	thus	thus	RB
cord-345472-qrddwebe	201	17	contribute	contribute	VB
cord-345472-qrddwebe	201	18	to	to	IN
cord-345472-qrddwebe	201	19	the	the	DT
cord-345472-qrddwebe	201	20	pathology	pathology	NN
cord-345472-qrddwebe	201	21	that	that	WDT
cord-345472-qrddwebe	201	22	occurs	occur	VBZ
cord-345472-qrddwebe	201	23	in	in	IN
cord-345472-qrddwebe	201	24	severe	severe	JJ
cord-345472-qrddwebe	201	25	RSV	RSV	NNP
cord-345472-qrddwebe	201	26	patients	patient	NNS
cord-345472-qrddwebe	201	27	.	.	.
cord-345472-qrddwebe	202	1	Excessive	excessive	JJ
cord-345472-qrddwebe	202	2	neutrophilia	neutrophilia	NN
cord-345472-qrddwebe	202	3	is	be	VBZ
cord-345472-qrddwebe	202	4	associated	associate	VBN
cord-345472-qrddwebe	202	5	with	with	IN
cord-345472-qrddwebe	202	6	increased	increase	VBN
cord-345472-qrddwebe	202	7	tissue	tissue	NN
cord-345472-qrddwebe	202	8	damage	damage	NN
cord-345472-qrddwebe	202	9	during	during	IN
cord-345472-qrddwebe	202	10	severe	severe	JJ
cord-345472-qrddwebe	202	11	RSV	RSV	NNP
cord-345472-qrddwebe	202	12	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	202	13	[	[	-LRB-
cord-345472-qrddwebe	202	14	130	130	CD
cord-345472-qrddwebe	202	15	]	]	-RRB-
cord-345472-qrddwebe	202	16	.	.	.
cord-345472-qrddwebe	203	1	In	in	IN
cord-345472-qrddwebe	203	2	part	part	NN
cord-345472-qrddwebe	203	3	,	,	,
cord-345472-qrddwebe	203	4	this	this	DT
cord-345472-qrddwebe	203	5	is	be	VBZ
cord-345472-qrddwebe	203	6	attributed	attribute	VBN
cord-345472-qrddwebe	203	7	to	to	IN
cord-345472-qrddwebe	203	8	molecular	molecular	JJ
cord-345472-qrddwebe	203	9	dysregulation	dysregulation	NN
cord-345472-qrddwebe	203	10	of	of	IN
cord-345472-qrddwebe	203	11	neutrophil	neutrophil	NN
cord-345472-qrddwebe	203	12	-	-	HYPH
cord-345472-qrddwebe	203	13	effector	effector	NN
cord-345472-qrddwebe	203	14	pathways	pathway	NNS
cord-345472-qrddwebe	203	15	,	,	,
cord-345472-qrddwebe	203	16	including	include	VBG
cord-345472-qrddwebe	203	17	ROS	ROS	NNP
cord-345472-qrddwebe	203	18	production	production	NN
cord-345472-qrddwebe	203	19	,	,	,
cord-345472-qrddwebe	203	20	NETosis	netosis	NN
cord-345472-qrddwebe	203	21	,	,	,
cord-345472-qrddwebe	203	22	degranulation	degranulation	NN
cord-345472-qrddwebe	203	23	,	,	,
cord-345472-qrddwebe	203	24	and	and	CC
cord-345472-qrddwebe	203	25	over	over	IN
cord-345472-qrddwebe	203	26	-	-	HYPH
cord-345472-qrddwebe	203	27	secretion	secretion	NN
cord-345472-qrddwebe	203	28	of	of	IN
cord-345472-qrddwebe	203	29	proteolytic	proteolytic	JJ
cord-345472-qrddwebe	203	30	enzymes	enzyme	NNS
cord-345472-qrddwebe	203	31	[	[	-LRB-
cord-345472-qrddwebe	203	32	101	101	CD
cord-345472-qrddwebe	203	33	,	,	,
cord-345472-qrddwebe	203	34	111	111	CD
cord-345472-qrddwebe	203	35	,	,	,
cord-345472-qrddwebe	203	36	[	[	-LRB-
cord-345472-qrddwebe	203	37	131	131	CD
cord-345472-qrddwebe	203	38	]	]	-RRB-
cord-345472-qrddwebe	203	39	[	[	-LRB-
cord-345472-qrddwebe	203	40	132	132	CD
cord-345472-qrddwebe	203	41	]	]	-RRB-
cord-345472-qrddwebe	203	42	[	[	-LRB-
cord-345472-qrddwebe	203	43	133	133	CD
cord-345472-qrddwebe	203	44	]	]	-RRB-
cord-345472-qrddwebe	203	45	[	[	-LRB-
cord-345472-qrddwebe	203	46	134	134	CD
cord-345472-qrddwebe	203	47	]	]	-RRB-
cord-345472-qrddwebe	203	48	,	,	,
cord-345472-qrddwebe	203	49	(	(	-LRB-
cord-345472-qrddwebe	203	50	highlighted	highlight	VBN
cord-345472-qrddwebe	203	51	in	in	IN
cord-345472-qrddwebe	203	52	Figure	Figure	NNP
cord-345472-qrddwebe	203	53	1	1	CD
cord-345472-qrddwebe	203	54	)	)	-RRB-
cord-345472-qrddwebe	203	55	.	.	.
cord-345472-qrddwebe	204	1	Excessive	excessive	JJ
cord-345472-qrddwebe	204	2	ROS	ROS	NNP
cord-345472-qrddwebe	204	3	production	production	NN
cord-345472-qrddwebe	204	4	activates	activate	VBZ
cord-345472-qrddwebe	204	5	indiscriminate	indiscriminate	JJ
cord-345472-qrddwebe	204	6	oxidative	oxidative	JJ
cord-345472-qrddwebe	204	7	stress	stress	NN
cord-345472-qrddwebe	204	8	in	in	IN
cord-345472-qrddwebe	204	9	the	the	DT
cord-345472-qrddwebe	204	10	lung	lung	NN
cord-345472-qrddwebe	204	11	,	,	,
cord-345472-qrddwebe	204	12	contributing	contribute	VBG
cord-345472-qrddwebe	204	13	to	to	IN
cord-345472-qrddwebe	204	14	lung	lung	NN
cord-345472-qrddwebe	204	15	damage	damage	NN
cord-345472-qrddwebe	204	16	[	[	-LRB-
cord-345472-qrddwebe	204	17	108	108	CD
cord-345472-qrddwebe	204	18	]	]	-RRB-
cord-345472-qrddwebe	204	19	[	[	-LRB-
cord-345472-qrddwebe	204	20	109	109	CD
cord-345472-qrddwebe	204	21	]	]	-RRB-
cord-345472-qrddwebe	204	22	[	[	-LRB-
cord-345472-qrddwebe	204	23	110	110	CD
cord-345472-qrddwebe	204	24	]	]	-RRB-
cord-345472-qrddwebe	204	25	.	.	.
cord-345472-qrddwebe	205	1	Indeed	indeed	RB
cord-345472-qrddwebe	205	2	,	,	,
cord-345472-qrddwebe	205	3	markers	marker	NNS
cord-345472-qrddwebe	205	4	of	of	IN
cord-345472-qrddwebe	205	5	oxidative	oxidative	JJ
cord-345472-qrddwebe	205	6	stress	stress	NN
cord-345472-qrddwebe	205	7	are	be	VBP
cord-345472-qrddwebe	205	8	elevated	elevate	VBN
cord-345472-qrddwebe	205	9	in	in	IN
cord-345472-qrddwebe	205	10	the	the	DT
cord-345472-qrddwebe	205	11	lungs	lung	NNS
cord-345472-qrddwebe	205	12	and	and	CC
cord-345472-qrddwebe	205	13	blood	blood	NN
cord-345472-qrddwebe	205	14	of	of	IN
cord-345472-qrddwebe	205	15	patients	patient	NNS
cord-345472-qrddwebe	205	16	with	with	IN
cord-345472-qrddwebe	205	17	severe	severe	JJ
cord-345472-qrddwebe	205	18	RSV	RSV	NNP
cord-345472-qrddwebe	205	19	[	[	-LRB-
cord-345472-qrddwebe	205	20	108	108	CD
cord-345472-qrddwebe	205	21	]	]	-RRB-
cord-345472-qrddwebe	205	22	.	.	.
cord-345472-qrddwebe	206	1	In	in	IN
cord-345472-qrddwebe	206	2	vivo	vivo	NN
cord-345472-qrddwebe	206	3	treatment	treatment	NN
cord-345472-qrddwebe	206	4	of	of	IN
cord-345472-qrddwebe	206	5	mice	mouse	NNS
cord-345472-qrddwebe	206	6	with	with	IN
cord-345472-qrddwebe	206	7	antioxidants	antioxidant	NNS
cord-345472-qrddwebe	206	8	significantly	significantly	RB
cord-345472-qrddwebe	206	9	reduces	reduce	VBZ
cord-345472-qrddwebe	206	10	RSV	RSV	NNP
cord-345472-qrddwebe	206	11	-	-	HYPH
cord-345472-qrddwebe	206	12	induced	induce	VBN
cord-345472-qrddwebe	206	13	inflammation	inflammation	NN
cord-345472-qrddwebe	206	14	and	and	CC
cord-345472-qrddwebe	206	15	pathology	pathology	NN
cord-345472-qrddwebe	206	16	[	[	-LRB-
cord-345472-qrddwebe	206	17	108	108	CD
cord-345472-qrddwebe	206	18	]	]	-RRB-
cord-345472-qrddwebe	206	19	.	.	.
cord-345472-qrddwebe	207	1	NE	NE	NNP
cord-345472-qrddwebe	207	2	levels	level	NNS
cord-345472-qrddwebe	207	3	are	be	VBP
cord-345472-qrddwebe	207	4	heightened	heighten	VBN
cord-345472-qrddwebe	207	5	in	in	IN
cord-345472-qrddwebe	207	6	nasal	nasal	NN
cord-345472-qrddwebe	207	7	aspirates	aspirate	NNS
cord-345472-qrddwebe	207	8	and	and	CC
cord-345472-qrddwebe	207	9	serum	serum	NN
cord-345472-qrddwebe	207	10	from	from	IN
cord-345472-qrddwebe	207	11	paediatric	paediatric	JJ
cord-345472-qrddwebe	207	12	patients	patient	NNS
cord-345472-qrddwebe	207	13	with	with	IN
cord-345472-qrddwebe	207	14	acute	acute	JJ
cord-345472-qrddwebe	207	15	RSV	RSV	NNP
cord-345472-qrddwebe	207	16	infection	infection	NN
cord-345472-qrddwebe	207	17	compared	compare	VBN
cord-345472-qrddwebe	207	18	with	with	IN
cord-345472-qrddwebe	207	19	uninfected	uninfected	JJ
cord-345472-qrddwebe	207	20	controls	control	NNS
cord-345472-qrddwebe	207	21	[	[	-LRB-
cord-345472-qrddwebe	207	22	68	68	CD
cord-345472-qrddwebe	207	23	,	,	,
cord-345472-qrddwebe	207	24	106	106	CD
cord-345472-qrddwebe	207	25	]	]	-RRB-
cord-345472-qrddwebe	207	26	,	,	,
cord-345472-qrddwebe	207	27	and	and	CC
cord-345472-qrddwebe	207	28	NETs	net	NNS
cord-345472-qrddwebe	207	29	are	be	VBP
cord-345472-qrddwebe	207	30	readily	readily	RB
cord-345472-qrddwebe	207	31	detected	detect	VBN
cord-345472-qrddwebe	207	32	in	in	IN
cord-345472-qrddwebe	207	33	BALF	BALF	NNP
cord-345472-qrddwebe	207	34	samples	sample	NNS
cord-345472-qrddwebe	207	35	obtained	obtain	VBN
cord-345472-qrddwebe	207	36	from	from	IN
cord-345472-qrddwebe	207	37	patients	patient	NNS
cord-345472-qrddwebe	207	38	with	with	IN
cord-345472-qrddwebe	207	39	an	an	DT
cord-345472-qrddwebe	207	40	RSV	RSV	NNP
cord-345472-qrddwebe	207	41	infection	infection	NN
cord-345472-qrddwebe	207	42	[	[	-LRB-
cord-345472-qrddwebe	207	43	111	111	CD
cord-345472-qrddwebe	207	44	]	]	-RRB-
cord-345472-qrddwebe	207	45	.	.	.
cord-345472-qrddwebe	208	1	In	in	IN
cord-345472-qrddwebe	208	2	another	another	DT
cord-345472-qrddwebe	208	3	study	study	NN
cord-345472-qrddwebe	208	4	that	that	WDT
cord-345472-qrddwebe	208	5	sampled	sample	VBD
cord-345472-qrddwebe	208	6	patients	patient	NNS
cord-345472-qrddwebe	208	7	with	with	IN
cord-345472-qrddwebe	208	8	RSV	RSV	NNP
cord-345472-qrddwebe	208	9	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	208	10	,	,	,
cord-345472-qrddwebe	208	11	blood	blood	NN
cord-345472-qrddwebe	208	12	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	208	13	showed	show	VBD
cord-345472-qrddwebe	208	14	little	little	JJ
cord-345472-qrddwebe	208	15	NET	net	NN
cord-345472-qrddwebe	208	16	formation	formation	NN
cord-345472-qrddwebe	208	17	,	,	,
cord-345472-qrddwebe	208	18	whereas	whereas	IN
cord-345472-qrddwebe	208	19	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	208	20	from	from	IN
cord-345472-qrddwebe	208	21	the	the	DT
cord-345472-qrddwebe	208	22	airways	airways	NNPS
cord-345472-qrddwebe	208	23	underwent	undergo	VBD
cord-345472-qrddwebe	208	24	NETosis	NETosis	NNP
cord-345472-qrddwebe	208	25	[	[	-LRB-
cord-345472-qrddwebe	208	26	117	117	CD
cord-345472-qrddwebe	208	27	]	]	-RRB-
cord-345472-qrddwebe	208	28	.	.	.
cord-345472-qrddwebe	209	1	Intriguingly	intriguingly	RB
cord-345472-qrddwebe	209	2	,	,	,
cord-345472-qrddwebe	209	3	in	in	IN
cord-345472-qrddwebe	209	4	an	an	DT
cord-345472-qrddwebe	209	5	ex	ex	FW
cord-345472-qrddwebe	209	6	vivo	vivo	NN
cord-345472-qrddwebe	209	7	model	model	NN
cord-345472-qrddwebe	209	8	,	,	,
cord-345472-qrddwebe	209	9	this	this	DT
cord-345472-qrddwebe	209	10	process	process	NN
cord-345472-qrddwebe	209	11	was	be	VBD
cord-345472-qrddwebe	209	12	diminished	diminish	VBN
cord-345472-qrddwebe	209	13	,	,	,
cord-345472-qrddwebe	209	14	with	with	IN
cord-345472-qrddwebe	209	15	an	an	DT
cord-345472-qrddwebe	209	16	agonistic	agonistic	JJ
cord-345472-qrddwebe	209	17	antibody	antibody	NN
cord-345472-qrddwebe	209	18	directed	direct	VBN
cord-345472-qrddwebe	209	19	against	against	IN
cord-345472-qrddwebe	209	20	LAIR-1	lair-1	NN
cord-345472-qrddwebe	209	21	,	,	,
cord-345472-qrddwebe	209	22	which	which	WDT
cord-345472-qrddwebe	209	23	was	be	VBD
cord-345472-qrddwebe	209	24	shown	show	VBN
cord-345472-qrddwebe	209	25	to	to	TO
cord-345472-qrddwebe	209	26	be	be	VB
cord-345472-qrddwebe	209	27	elevated	elevate	VBN
cord-345472-qrddwebe	209	28	on	on	IN
cord-345472-qrddwebe	209	29	airway	airway	JJ
cord-345472-qrddwebe	209	30	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	209	31	but	but	CC
cord-345472-qrddwebe	209	32	not	not	RB
cord-345472-qrddwebe	209	33	on	on	IN
cord-345472-qrddwebe	209	34	circulating	circulate	VBG
cord-345472-qrddwebe	209	35	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	209	36	[	[	-LRB-
cord-345472-qrddwebe	209	37	117	117	CD
cord-345472-qrddwebe	209	38	]	]	-RRB-
cord-345472-qrddwebe	209	39	.	.	.
cord-345472-qrddwebe	210	1	In	in	IN
cord-345472-qrddwebe	210	2	vitro	vitro	FW
cord-345472-qrddwebe	210	3	stimulation	stimulation	NN
cord-345472-qrddwebe	210	4	of	of	IN
cord-345472-qrddwebe	210	5	human	human	JJ
cord-345472-qrddwebe	210	6	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	210	7	with	with	IN
cord-345472-qrddwebe	210	8	RSV	RSV	NNP
cord-345472-qrddwebe	210	9	virions	virion	NNS
cord-345472-qrddwebe	210	10	induces	induce	VBZ
cord-345472-qrddwebe	210	11	ROS	ROS	NNP
cord-345472-qrddwebe	210	12	-	-	HYPH
cord-345472-qrddwebe	210	13	dependent	dependent	JJ
cord-345472-qrddwebe	210	14	NETosis	netosis	NN
cord-345472-qrddwebe	210	15	via	via	IN
cord-345472-qrddwebe	210	16	PAD-4	PAD-4	NNP
cord-345472-qrddwebe	210	17	citrullination	citrullination	NN
cord-345472-qrddwebe	210	18	and	and	CC
cord-345472-qrddwebe	210	19	downstream	downstream	JJ
cord-345472-qrddwebe	210	20	activation	activation	NN
cord-345472-qrddwebe	210	21	of	of	IN
cord-345472-qrddwebe	210	22	the	the	DT
cord-345472-qrddwebe	210	23	PI3K	PI3K	NNP
cord-345472-qrddwebe	210	24	/	/	SYM
cord-345472-qrddwebe	210	25	AKT	AKT	NNP
cord-345472-qrddwebe	210	26	,	,	,
cord-345472-qrddwebe	210	27	ERK	ERK	NNP
cord-345472-qrddwebe	210	28	,	,	,
cord-345472-qrddwebe	210	29	and	and	CC
cord-345472-qrddwebe	210	30	p38	p38	CD
cord-345472-qrddwebe	210	31	MAPK	MAPK	NNP
cord-345472-qrddwebe	210	32	pathways	pathway	NNS
cord-345472-qrddwebe	210	33	[	[	-LRB-
cord-345472-qrddwebe	210	34	131	131	CD
cord-345472-qrddwebe	210	35	]	]	-RRB-
cord-345472-qrddwebe	210	36	.	.	.
cord-345472-qrddwebe	211	1	The	the	DT
cord-345472-qrddwebe	211	2	deposition	deposition	NN
cord-345472-qrddwebe	211	3	of	of	IN
cord-345472-qrddwebe	211	4	NET	net	JJ
cord-345472-qrddwebe	211	5	products	product	NNS
cord-345472-qrddwebe	211	6	in	in	IN
cord-345472-qrddwebe	211	7	the	the	DT
cord-345472-qrddwebe	211	8	culture	culture	NN
cord-345472-qrddwebe	211	9	was	be	VBD
cord-345472-qrddwebe	211	10	shown	show	VBN
cord-345472-qrddwebe	211	11	to	to	TO
cord-345472-qrddwebe	211	12	trap	trap	VB
cord-345472-qrddwebe	211	13	RSV	RSV	NNP
cord-345472-qrddwebe	211	14	virions	virion	NNS
cord-345472-qrddwebe	211	15	in	in	IN
cord-345472-qrddwebe	211	16	DNA	dna	NN
cord-345472-qrddwebe	211	17	lattices	lattice	NNS
cord-345472-qrddwebe	211	18	coated	coat	VBN
cord-345472-qrddwebe	211	19	with	with	IN
cord-345472-qrddwebe	211	20	NE	NE	NNP
cord-345472-qrddwebe	211	21	and	and	CC
cord-345472-qrddwebe	211	22	MPO	MPO	NNP
cord-345472-qrddwebe	211	23	,	,	,
cord-345472-qrddwebe	211	24	implicating	implicate	VBG
cord-345472-qrddwebe	211	25	a	a	DT
cord-345472-qrddwebe	211	26	beneficial	beneficial	JJ
cord-345472-qrddwebe	211	27	antiviral	antiviral	JJ
cord-345472-qrddwebe	211	28	effect	effect	NN
cord-345472-qrddwebe	211	29	of	of	IN
cord-345472-qrddwebe	211	30	NETs	net	NNS
cord-345472-qrddwebe	211	31	[	[	-LRB-
cord-345472-qrddwebe	211	32	131	131	CD
cord-345472-qrddwebe	211	33	]	]	-RRB-
cord-345472-qrddwebe	211	34	.	.	.
cord-345472-qrddwebe	212	1	However	however	RB
cord-345472-qrddwebe	212	2	,	,	,
cord-345472-qrddwebe	212	3	in	in	IN
cord-345472-qrddwebe	212	4	calves	calf	NNS
cord-345472-qrddwebe	212	5	with	with	IN
cord-345472-qrddwebe	212	6	a	a	DT
cord-345472-qrddwebe	212	7	severe	severe	JJ
cord-345472-qrddwebe	212	8	bovine	bovine	JJ
cord-345472-qrddwebe	212	9	RSV	rsv	NN
cord-345472-qrddwebe	212	10	infection	infection	NN
cord-345472-qrddwebe	212	11	,	,	,
cord-345472-qrddwebe	212	12	the	the	DT
cord-345472-qrddwebe	212	13	widespread	widespread	JJ
cord-345472-qrddwebe	212	14	airway	airway	NN
cord-345472-qrddwebe	212	15	obstruction	obstruction	NN
cord-345472-qrddwebe	212	16	is	be	VBZ
cord-345472-qrddwebe	212	17	caused	cause	VBN
cord-345472-qrddwebe	212	18	by	by	IN
cord-345472-qrddwebe	212	19	luminal	luminal	JJ
cord-345472-qrddwebe	212	20	plugs	plug	NNS
cord-345472-qrddwebe	212	21	composed	compose	VBN
cord-345472-qrddwebe	212	22	of	of	IN
cord-345472-qrddwebe	212	23	mucins	mucin	NNS
cord-345472-qrddwebe	212	24	,	,	,
cord-345472-qrddwebe	212	25	cellular	cellular	JJ
cord-345472-qrddwebe	212	26	debris	debris	NN
cord-345472-qrddwebe	212	27	,	,	,
cord-345472-qrddwebe	212	28	and	and	CC
cord-345472-qrddwebe	212	29	NETs	net	NNS
cord-345472-qrddwebe	212	30	[	[	-LRB-
cord-345472-qrddwebe	212	31	111	111	CD
cord-345472-qrddwebe	212	32	]	]	-RRB-
cord-345472-qrddwebe	212	33	.	.	.
cord-345472-qrddwebe	213	1	As	as	IN
cord-345472-qrddwebe	213	2	DNA	dna	NN
cord-345472-qrddwebe	213	3	-	-	HYPH
cord-345472-qrddwebe	213	4	rich	rich	JJ
cord-345472-qrddwebe	213	5	mucus	mucus	NN
cord-345472-qrddwebe	213	6	is	be	VBZ
cord-345472-qrddwebe	213	7	associated	associate	VBN
cord-345472-qrddwebe	213	8	with	with	IN
cord-345472-qrddwebe	213	9	airway	airway	JJ
cord-345472-qrddwebe	213	10	obstruction	obstruction	NN
cord-345472-qrddwebe	213	11	[	[	-LRB-
cord-345472-qrddwebe	213	12	111	111	CD
cord-345472-qrddwebe	213	13	,	,	,
cord-345472-qrddwebe	213	14	121	121	CD
cord-345472-qrddwebe	213	15	]	]	-RRB-
cord-345472-qrddwebe	213	16	,	,	,
cord-345472-qrddwebe	213	17	excessive	excessive	JJ
cord-345472-qrddwebe	213	18	NET	net	NN
cord-345472-qrddwebe	213	19	release	release	NN
cord-345472-qrddwebe	213	20	likely	likely	RB
cord-345472-qrddwebe	213	21	contributes	contribute	VBZ
cord-345472-qrddwebe	213	22	to	to	IN
cord-345472-qrddwebe	213	23	pathogenesis	pathogenesis	NN
cord-345472-qrddwebe	213	24	,	,	,
cord-345472-qrddwebe	213	25	although	although	IN
cord-345472-qrddwebe	213	26	this	this	DT
cord-345472-qrddwebe	213	27	has	have	VBZ
cord-345472-qrddwebe	213	28	yet	yet	RB
cord-345472-qrddwebe	213	29	to	to	TO
cord-345472-qrddwebe	213	30	be	be	VB
cord-345472-qrddwebe	213	31	demonstrated	demonstrate	VBN
cord-345472-qrddwebe	213	32	clinically	clinically	RB
cord-345472-qrddwebe	213	33	or	or	CC
cord-345472-qrddwebe	213	34	in	in	IN
cord-345472-qrddwebe	213	35	an	an	DT
cord-345472-qrddwebe	213	36	experimental	experimental	JJ
cord-345472-qrddwebe	213	37	animal	animal	NN
cord-345472-qrddwebe	213	38	model	model	NN
cord-345472-qrddwebe	213	39	of	of	IN
cord-345472-qrddwebe	213	40	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	213	41	.	.	.
cord-345472-qrddwebe	214	1	Findings	finding	NNS
cord-345472-qrddwebe	214	2	from	from	IN
cord-345472-qrddwebe	214	3	other	other	JJ
cord-345472-qrddwebe	214	4	experimental	experimental	JJ
cord-345472-qrddwebe	214	5	systems	system	NNS
cord-345472-qrddwebe	214	6	such	such	JJ
cord-345472-qrddwebe	214	7	as	as	IN
cord-345472-qrddwebe	214	8	allergic	allergic	JJ
cord-345472-qrddwebe	214	9	asthma	asthma	NNS
cord-345472-qrddwebe	214	10	have	have	VBP
cord-345472-qrddwebe	214	11	demonstrated	demonstrate	VBN
cord-345472-qrddwebe	214	12	that	that	IN
cord-345472-qrddwebe	214	13	NETs	net	NNS
cord-345472-qrddwebe	214	14	can	can	MD
cord-345472-qrddwebe	214	15	exacerbate	exacerbate	VB
cord-345472-qrddwebe	214	16	immunopathology	immunopathology	NN
cord-345472-qrddwebe	214	17	[	[	-LRB-
cord-345472-qrddwebe	214	18	39	39	CD
cord-345472-qrddwebe	214	19	]	]	-RRB-
cord-345472-qrddwebe	214	20	.	.	.
cord-345472-qrddwebe	215	1	Virus	virus	NN
cord-345472-qrddwebe	215	2	-	-	HYPH
cord-345472-qrddwebe	215	3	associated	associate	VBN
cord-345472-qrddwebe	215	4	exacerbations	exacerbation	NNS
cord-345472-qrddwebe	215	5	of	of	IN
cord-345472-qrddwebe	215	6	asthma	asthma	NNS
cord-345472-qrddwebe	215	7	are	be	VBP
cord-345472-qrddwebe	215	8	attenuated	attenuate	VBN
cord-345472-qrddwebe	215	9	following	follow	VBG
cord-345472-qrddwebe	215	10	inhibition	inhibition	NN
cord-345472-qrddwebe	215	11	of	of	IN
cord-345472-qrddwebe	215	12	NETosis	NETosis	NNP
cord-345472-qrddwebe	215	13	,	,	,
cord-345472-qrddwebe	215	14	either	either	CC
cord-345472-qrddwebe	215	15	through	through	IN
cord-345472-qrddwebe	215	16	blockade	blockade	NN
cord-345472-qrddwebe	215	17	of	of	IN
cord-345472-qrddwebe	215	18	NE	NE	NNP
cord-345472-qrddwebe	215	19	or	or	CC
cord-345472-qrddwebe	215	20	degradation	degradation	NN
cord-345472-qrddwebe	215	21	of	of	IN
cord-345472-qrddwebe	215	22	NETs	net	NNS
cord-345472-qrddwebe	215	23	with	with	IN
cord-345472-qrddwebe	215	24	DNase	DNase	NNP
cord-345472-qrddwebe	215	25	[	[	-LRB-
cord-345472-qrddwebe	215	26	39	39	CD
cord-345472-qrddwebe	215	27	]	]	-RRB-
cord-345472-qrddwebe	215	28	.	.	.
cord-345472-qrddwebe	216	1	Mechanistically	Mechanistically	NNP
cord-345472-qrddwebe	216	2	,	,	,
cord-345472-qrddwebe	216	3	NETosis	NETosis	NNP
cord-345472-qrddwebe	216	4	inhibition	inhibition	NN
cord-345472-qrddwebe	216	5	reduced	reduce	VBN
cord-345472-qrddwebe	216	6	type	type	NN
cord-345472-qrddwebe	216	7	2-mediated	2-mediated	CD
cord-345472-qrddwebe	216	8	allergic	allergic	JJ
cord-345472-qrddwebe	216	9	inflammation	inflammation	NN
cord-345472-qrddwebe	216	10	and	and	CC
cord-345472-qrddwebe	216	11	lowered	lower	VBD
cord-345472-qrddwebe	216	12	airway	airway	NN
cord-345472-qrddwebe	216	13	hyper	hyper	NN
cord-345472-qrddwebe	216	14	-	-	NN
cord-345472-qrddwebe	216	15	reactivity	reactivity	NN
cord-345472-qrddwebe	216	16	[	[	-LRB-
cord-345472-qrddwebe	216	17	39	39	CD
cord-345472-qrddwebe	216	18	]	]	-RRB-
cord-345472-qrddwebe	216	19	.	.	.
cord-345472-qrddwebe	217	1	Clearly	clearly	RB
cord-345472-qrddwebe	217	2	,	,	,
cord-345472-qrddwebe	217	3	as	as	IN
cord-345472-qrddwebe	217	4	with	with	IN
cord-345472-qrddwebe	217	5	most	most	JJS
cord-345472-qrddwebe	217	6	inflammatory	inflammatory	JJ
cord-345472-qrddwebe	217	7	processes	process	NNS
cord-345472-qrddwebe	217	8	,	,	,
cord-345472-qrddwebe	217	9	NETosis	NETosis	NNP
cord-345472-qrddwebe	217	10	is	be	VBZ
cord-345472-qrddwebe	217	11	a	a	DT
cord-345472-qrddwebe	217	12	double	double	RB
cord-345472-qrddwebe	217	13	-	-	HYPH
cord-345472-qrddwebe	217	14	edged	edged	JJ
cord-345472-qrddwebe	217	15	sword	sword	NN
cord-345472-qrddwebe	217	16	.	.	.
cord-345472-qrddwebe	218	1	A	a	DT
cord-345472-qrddwebe	218	2	greater	great	JJR
cord-345472-qrddwebe	218	3	understanding	understanding	NN
cord-345472-qrddwebe	218	4	of	of	IN
cord-345472-qrddwebe	218	5	NETosis	netosis	NN
cord-345472-qrddwebe	218	6	in	in	IN
cord-345472-qrddwebe	218	7	the	the	DT
cord-345472-qrddwebe	218	8	context	context	NN
cord-345472-qrddwebe	218	9	of	of	IN
cord-345472-qrddwebe	218	10	acute	acute	JJ
cord-345472-qrddwebe	218	11	LRIs	LRIs	NNP
cord-345472-qrddwebe	218	12	is	be	VBZ
cord-345472-qrddwebe	218	13	needed	need	VBN
cord-345472-qrddwebe	218	14	;	;	:
cord-345472-qrddwebe	218	15	however	however	RB
cord-345472-qrddwebe	218	16	,	,	,
cord-345472-qrddwebe	218	17	on	on	IN
cord-345472-qrddwebe	218	18	balance	balance	NN
cord-345472-qrddwebe	218	19	it	-PRON-	PRP
cord-345472-qrddwebe	218	20	appears	appear	VBZ
cord-345472-qrddwebe	218	21	that	that	IN
cord-345472-qrddwebe	218	22	limiting	limit	VBG
cord-345472-qrddwebe	218	23	NETosis	netosis	NN
cord-345472-qrddwebe	218	24	in	in	IN
cord-345472-qrddwebe	218	25	severe	severe	JJ
cord-345472-qrddwebe	218	26	RSV	RSV	NNP
cord-345472-qrddwebe	218	27	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	218	28	would	would	MD
cord-345472-qrddwebe	218	29	be	be	VB
cord-345472-qrddwebe	218	30	advantageous	advantageous	JJ
cord-345472-qrddwebe	218	31	.	.	.
cord-345472-qrddwebe	219	1	Neutrophil	Neutrophil	NNP
cord-345472-qrddwebe	219	2	-	-	HYPH
cord-345472-qrddwebe	219	3	derived	derive	VBN
cord-345472-qrddwebe	219	4	toxic	toxic	JJ
cord-345472-qrddwebe	219	5	granules	granule	NNS
cord-345472-qrddwebe	219	6	and	and	CC
cord-345472-qrddwebe	219	7	proteolytic	proteolytic	JJ
cord-345472-qrddwebe	219	8	enzymes	enzyme	NNS
cord-345472-qrddwebe	219	9	also	also	RB
cord-345472-qrddwebe	219	10	contribute	contribute	VBP
cord-345472-qrddwebe	219	11	to	to	IN
cord-345472-qrddwebe	219	12	the	the	DT
cord-345472-qrddwebe	219	13	pathogenesis	pathogenesis	NN
cord-345472-qrddwebe	219	14	of	of	IN
cord-345472-qrddwebe	219	15	RSV	RSV	NNP
cord-345472-qrddwebe	219	16	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	219	17	.	.	.
cord-345472-qrddwebe	220	1	RSV	RSV	NNP
cord-345472-qrddwebe	220	2	increases	increase	VBZ
cord-345472-qrddwebe	220	3	the	the	DT
cord-345472-qrddwebe	220	4	expression	expression	NN
cord-345472-qrddwebe	220	5	of	of	IN
cord-345472-qrddwebe	220	6	matrix	matrix	NN
cord-345472-qrddwebe	220	7	metalloproteinase-9	metalloproteinase-9	NNP
cord-345472-qrddwebe	220	8	(	(	-LRB-
cord-345472-qrddwebe	220	9	MMP-9	MMP-9	NNP
cord-345472-qrddwebe	220	10	)	)	-RRB-
cord-345472-qrddwebe	220	11	,	,	,
cord-345472-qrddwebe	220	12	which	which	WDT
cord-345472-qrddwebe	220	13	augments	augment	VBZ
cord-345472-qrddwebe	220	14	the	the	DT
cord-345472-qrddwebe	220	15	influx	influx	NN
cord-345472-qrddwebe	220	16	of	of	IN
cord-345472-qrddwebe	220	17	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	220	18	to	to	IN
cord-345472-qrddwebe	220	19	the	the	DT
cord-345472-qrddwebe	220	20	site	site	NN
cord-345472-qrddwebe	220	21	of	of	IN
cord-345472-qrddwebe	220	22	infection	infection	NN
cord-345472-qrddwebe	220	23	[	[	-LRB-
cord-345472-qrddwebe	220	24	107	107	CD
cord-345472-qrddwebe	220	25	]	]	-RRB-
cord-345472-qrddwebe	220	26	.	.	.
cord-345472-qrddwebe	221	1	Elevated	elevated	JJ
cord-345472-qrddwebe	221	2	levels	level	NNS
cord-345472-qrddwebe	221	3	of	of	IN
cord-345472-qrddwebe	221	4	MMP-9	MMP-9	NNP
cord-345472-qrddwebe	221	5	are	be	VBP
cord-345472-qrddwebe	221	6	detected	detect	VBN
cord-345472-qrddwebe	221	7	in	in	IN
cord-345472-qrddwebe	221	8	the	the	DT
cord-345472-qrddwebe	221	9	respiratory	respiratory	JJ
cord-345472-qrddwebe	221	10	secretions	secretion	NNS
cord-345472-qrddwebe	221	11	of	of	IN
cord-345472-qrddwebe	221	12	RSV	RSV	NNP
cord-345472-qrddwebe	221	13	-	-	HYPH
cord-345472-qrddwebe	221	14	infected	infect	VBN
cord-345472-qrddwebe	221	15	paediatric	paediatric	JJ
cord-345472-qrddwebe	221	16	patients	patient	NNS
cord-345472-qrddwebe	221	17	and	and	CC
cord-345472-qrddwebe	221	18	are	be	VBP
cord-345472-qrddwebe	221	19	associated	associate	VBN
cord-345472-qrddwebe	221	20	with	with	IN
cord-345472-qrddwebe	221	21	increased	increase	VBN
cord-345472-qrddwebe	221	22	risk	risk	NN
cord-345472-qrddwebe	221	23	of	of	IN
cord-345472-qrddwebe	221	24	requiring	require	VBG
cord-345472-qrddwebe	221	25	mechanical	mechanical	JJ
cord-345472-qrddwebe	221	26	ventilation	ventilation	NN
cord-345472-qrddwebe	221	27	[	[	-LRB-
cord-345472-qrddwebe	221	28	133	133	CD
cord-345472-qrddwebe	221	29	]	]	-RRB-
cord-345472-qrddwebe	221	30	[	[	-LRB-
cord-345472-qrddwebe	221	31	134	134	CD
cord-345472-qrddwebe	221	32	]	]	-RRB-
cord-345472-qrddwebe	221	33	[	[	-LRB-
cord-345472-qrddwebe	221	34	135	135	CD
cord-345472-qrddwebe	221	35	]	]	-RRB-
cord-345472-qrddwebe	221	36	.	.	.
cord-345472-qrddwebe	222	1	Hence	hence	RB
cord-345472-qrddwebe	222	2	,	,	,
cord-345472-qrddwebe	222	3	MMP-9	MMP-9	NNP
cord-345472-qrddwebe	222	4	activity	activity	NN
cord-345472-qrddwebe	222	5	is	be	VBZ
cord-345472-qrddwebe	222	6	considered	consider	VBN
cord-345472-qrddwebe	222	7	a	a	DT
cord-345472-qrddwebe	222	8	useful	useful	JJ
cord-345472-qrddwebe	222	9	predictor	predictor	NN
cord-345472-qrddwebe	222	10	of	of	IN
cord-345472-qrddwebe	222	11	disease	disease	NN
cord-345472-qrddwebe	222	12	severity	severity	NN
cord-345472-qrddwebe	222	13	in	in	IN
cord-345472-qrddwebe	222	14	children	child	NNS
cord-345472-qrddwebe	222	15	with	with	IN
cord-345472-qrddwebe	222	16	RSV	RSV	NNP
cord-345472-qrddwebe	222	17	-	-	HYPH
cord-345472-qrddwebe	222	18	induced	induce	VBN
cord-345472-qrddwebe	222	19	respiratory	respiratory	JJ
cord-345472-qrddwebe	222	20	failure	failure	NN
cord-345472-qrddwebe	222	21	[	[	-LRB-
cord-345472-qrddwebe	222	22	133	133	CD
cord-345472-qrddwebe	222	23	]	]	-RRB-
cord-345472-qrddwebe	222	24	.	.	.
cord-345472-qrddwebe	223	1	Genetic	genetic	JJ
cord-345472-qrddwebe	223	2	MMP-9	MMP-9	NNP
cord-345472-qrddwebe	223	3	deficiency	deficiency	NN
cord-345472-qrddwebe	223	4	in	in	IN
cord-345472-qrddwebe	223	5	mice	mice	NN
cord-345472-qrddwebe	223	6	decreases	decrease	VBZ
cord-345472-qrddwebe	223	7	viral	viral	JJ
cord-345472-qrddwebe	223	8	burden	burden	NN
cord-345472-qrddwebe	223	9	and	and	CC
cord-345472-qrddwebe	223	10	lung	lung	NN
cord-345472-qrddwebe	223	11	inflammation	inflammation	NN
cord-345472-qrddwebe	223	12	[	[	-LRB-
cord-345472-qrddwebe	223	13	134	134	CD
cord-345472-qrddwebe	223	14	]	]	-RRB-
cord-345472-qrddwebe	223	15	,	,	,
cord-345472-qrddwebe	223	16	although	although	IN
cord-345472-qrddwebe	223	17	it	-PRON-	PRP
cord-345472-qrddwebe	223	18	is	be	VBZ
cord-345472-qrddwebe	223	19	still	still	RB
cord-345472-qrddwebe	223	20	unclear	unclear	JJ
cord-345472-qrddwebe	223	21	whether	whether	IN
cord-345472-qrddwebe	223	22	neutrophil	neutrophil	NN
cord-345472-qrddwebe	223	23	-	-	HYPH
cord-345472-qrddwebe	223	24	derived	derive	VBN
cord-345472-qrddwebe	223	25	MMP-9	MMP-9	NNP
cord-345472-qrddwebe	223	26	plays	play	VBZ
cord-345472-qrddwebe	223	27	a	a	DT
cord-345472-qrddwebe	223	28	dominant	dominant	JJ
cord-345472-qrddwebe	223	29	role	role	NN
cord-345472-qrddwebe	223	30	in	in	IN
cord-345472-qrddwebe	223	31	the	the	DT
cord-345472-qrddwebe	223	32	MMP-9-induced	mmp-9-induce	VBN
cord-345472-qrddwebe	223	33	pathology	pathology	NN
cord-345472-qrddwebe	223	34	during	during	IN
cord-345472-qrddwebe	223	35	RSV	RSV	NNP
cord-345472-qrddwebe	223	36	infection	infection	NN
cord-345472-qrddwebe	223	37	.	.	.
cord-345472-qrddwebe	224	1	Specific	specific	JJ
cord-345472-qrddwebe	224	2	ablation	ablation	NN
cord-345472-qrddwebe	224	3	of	of	IN
cord-345472-qrddwebe	224	4	MMP-9	MMP-9	NNP
cord-345472-qrddwebe	224	5	in	in	IN
cord-345472-qrddwebe	224	6	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	224	7	using	use	VBG
cord-345472-qrddwebe	224	8	Cre	Cre	NNP
cord-345472-qrddwebe	224	9	-	-	HYPH
cord-345472-qrddwebe	224	10	recombinase	recombinase	NNP
cord-345472-qrddwebe	224	11	-	-	HYPH
cord-345472-qrddwebe	224	12	LoxP	LoxP	NNP
cord-345472-qrddwebe	224	13	systems	system	NNS
cord-345472-qrddwebe	224	14	would	would	MD
cord-345472-qrddwebe	224	15	help	help	VB
cord-345472-qrddwebe	224	16	address	address	VB
cord-345472-qrddwebe	224	17	this	this	DT
cord-345472-qrddwebe	224	18	question	question	NN
cord-345472-qrddwebe	224	19	.	.	.
cord-345472-qrddwebe	225	1	In	in	IN
cord-345472-qrddwebe	225	2	summary	summary	NN
cord-345472-qrddwebe	225	3	,	,	,
cord-345472-qrddwebe	225	4	severe	severe	JJ
cord-345472-qrddwebe	225	5	neutrophilia	neutrophilia	NNP
cord-345472-qrddwebe	225	6	and	and	CC
cord-345472-qrddwebe	225	7	excessive	excessive	JJ
cord-345472-qrddwebe	225	8	production	production	NN
cord-345472-qrddwebe	225	9	of	of	IN
cord-345472-qrddwebe	225	10	powerful	powerful	JJ
cord-345472-qrddwebe	225	11	antimicrobial	antimicrobial	JJ
cord-345472-qrddwebe	225	12	mediators	mediator	NNS
cord-345472-qrddwebe	225	13	appears	appear	VBZ
cord-345472-qrddwebe	225	14	to	to	TO
cord-345472-qrddwebe	225	15	cause	cause	VB
cord-345472-qrddwebe	225	16	significant	significant	JJ
cord-345472-qrddwebe	225	17	collateral	collateral	JJ
cord-345472-qrddwebe	225	18	damage	damage	NN
cord-345472-qrddwebe	225	19	,	,	,
cord-345472-qrddwebe	225	20	resulting	result	VBG
cord-345472-qrddwebe	225	21	in	in	IN
cord-345472-qrddwebe	225	22	airway	airway	NN
cord-345472-qrddwebe	225	23	obstruction	obstruction	NN
cord-345472-qrddwebe	225	24	and	and	CC
cord-345472-qrddwebe	225	25	the	the	DT
cord-345472-qrddwebe	225	26	clinical	clinical	JJ
cord-345472-qrddwebe	225	27	symptoms	symptom	NNS
cord-345472-qrddwebe	225	28	that	that	WDT
cord-345472-qrddwebe	225	29	characterise	characterise	VBP
cord-345472-qrddwebe	225	30	severe	severe	JJ
cord-345472-qrddwebe	225	31	RSV	RSV	NNP
cord-345472-qrddwebe	225	32	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	225	33	.	.	.
cord-345472-qrddwebe	226	1	Pharmacological	pharmacological	JJ
cord-345472-qrddwebe	226	2	tools	tool	NNS
cord-345472-qrddwebe	226	3	to	to	TO
cord-345472-qrddwebe	226	4	inhibit	inhibit	VB
cord-345472-qrddwebe	226	5	the	the	DT
cord-345472-qrddwebe	226	6	excessive	excessive	JJ
cord-345472-qrddwebe	226	7	neutrophilic	neutrophilic	JJ
cord-345472-qrddwebe	226	8	response	response	NN
cord-345472-qrddwebe	226	9	in	in	IN
cord-345472-qrddwebe	226	10	the	the	DT
cord-345472-qrddwebe	226	11	lung	lung	NN
cord-345472-qrddwebe	226	12	are	be	VBP
cord-345472-qrddwebe	226	13	likely	likely	JJ
cord-345472-qrddwebe	226	14	to	to	TO
cord-345472-qrddwebe	226	15	ameliorate	ameliorate	VB
cord-345472-qrddwebe	226	16	the	the	DT
cord-345472-qrddwebe	226	17	severity	severity	NN
cord-345472-qrddwebe	226	18	of	of	IN
cord-345472-qrddwebe	226	19	RSV	RSV	NNP
cord-345472-qrddwebe	226	20	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	226	21	.	.	.
cord-345472-qrddwebe	227	1	To	to	TO
cord-345472-qrddwebe	227	2	achieve	achieve	VB
cord-345472-qrddwebe	227	3	this	this	DT
cord-345472-qrddwebe	227	4	goal	goal	NN
cord-345472-qrddwebe	227	5	,	,	,
cord-345472-qrddwebe	227	6	therapeutic	therapeutic	JJ
cord-345472-qrddwebe	227	7	strategies	strategy	NNS
cord-345472-qrddwebe	227	8	should	should	MD
cord-345472-qrddwebe	227	9	seek	seek	VB
cord-345472-qrddwebe	227	10	to	to	TO
cord-345472-qrddwebe	227	11	modify	modify	VB
cord-345472-qrddwebe	227	12	the	the	DT
cord-345472-qrddwebe	227	13	expression	expression	NN
cord-345472-qrddwebe	227	14	of	of	IN
cord-345472-qrddwebe	227	15	cytokines	cytokine	NNS
cord-345472-qrddwebe	227	16	and/or	and/or	CC
cord-345472-qrddwebe	227	17	chemokines	chemokine	NNS
cord-345472-qrddwebe	227	18	,	,	,
cord-345472-qrddwebe	227	19	which	which	WDT
cord-345472-qrddwebe	227	20	regulate	regulate	VBP
cord-345472-qrddwebe	227	21	neutrophil	neutrophil	NN
cord-345472-qrddwebe	227	22	trafficking	trafficking	NN
cord-345472-qrddwebe	227	23	/	/	SYM
cord-345472-qrddwebe	227	24	recruitment	recruitment	NN
cord-345472-qrddwebe	227	25	into	into	IN
cord-345472-qrddwebe	227	26	the	the	DT
cord-345472-qrddwebe	227	27	lung	lung	NN
cord-345472-qrddwebe	227	28	,	,	,
cord-345472-qrddwebe	227	29	and	and	CC
cord-345472-qrddwebe	227	30	neutrophil	neutrophil	NN
cord-345472-qrddwebe	227	31	activation	activation	NN
cord-345472-qrddwebe	227	32	and	and	CC
cord-345472-qrddwebe	227	33	function	function	NN
cord-345472-qrddwebe	227	34	in	in	IN
cord-345472-qrddwebe	227	35	response	response	NN
cord-345472-qrddwebe	227	36	to	to	IN
cord-345472-qrddwebe	227	37	infection	infection	NN
cord-345472-qrddwebe	227	38	(	(	-LRB-
cord-345472-qrddwebe	227	39	as	as	IN
cord-345472-qrddwebe	227	40	proposed	propose	VBN
cord-345472-qrddwebe	227	41	in	in	IN
cord-345472-qrddwebe	227	42	Figure	figure	NN
cord-345472-qrddwebe	227	43	2	2	CD
cord-345472-qrddwebe	227	44	)	)	-RRB-
cord-345472-qrddwebe	227	45	.	.	.
cord-345472-qrddwebe	228	1	Macrolide	macrolide	JJ
cord-345472-qrddwebe	228	2	antibiotics	antibiotic	NNS
cord-345472-qrddwebe	228	3	,	,	,
cord-345472-qrddwebe	228	4	in	in	IN
cord-345472-qrddwebe	228	5	particular	particular	JJ
cord-345472-qrddwebe	228	6	azithromycin	azithromycin	NN
cord-345472-qrddwebe	228	7	,	,	,
cord-345472-qrddwebe	228	8	which	which	WDT
cord-345472-qrddwebe	228	9	is	be	VBZ
cord-345472-qrddwebe	228	10	efficacious	efficacious	JJ
cord-345472-qrddwebe	228	11	against	against	IN
cord-345472-qrddwebe	228	12	IL-8	il-8	NN
cord-345472-qrddwebe	228	13	and	and	CC
cord-345472-qrddwebe	228	14	neutrophil	neutrophil	NN
cord-345472-qrddwebe	228	15	-	-	HYPH
cord-345472-qrddwebe	228	16	induced	induce	VBN
cord-345472-qrddwebe	228	17	inflammation	inflammation	NN
cord-345472-qrddwebe	228	18	,	,	,
cord-345472-qrddwebe	228	19	decrease	decrease	VB
cord-345472-qrddwebe	228	20	the	the	DT
cord-345472-qrddwebe	228	21	severity	severity	NN
cord-345472-qrddwebe	228	22	of	of	IN
cord-345472-qrddwebe	228	23	symptoms	symptom	NNS
cord-345472-qrddwebe	228	24	during	during	IN
cord-345472-qrddwebe	228	25	viral	viral	JJ
cord-345472-qrddwebe	228	26	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	228	27	[	[	-LRB-
cord-345472-qrddwebe	228	28	88	88	CD
cord-345472-qrddwebe	228	29	,	,	,
cord-345472-qrddwebe	228	30	136	136	CD
cord-345472-qrddwebe	228	31	,	,	,
cord-345472-qrddwebe	228	32	137	137	CD
cord-345472-qrddwebe	228	33	]	]	-RRB-
cord-345472-qrddwebe	228	34	.	.	.
cord-345472-qrddwebe	229	1	A	a	DT
cord-345472-qrddwebe	229	2	randomised	randomised	JJ
cord-345472-qrddwebe	229	3	trial	trial	NN
cord-345472-qrddwebe	229	4	in	in	IN
cord-345472-qrddwebe	229	5	infants	infant	NNS
cord-345472-qrddwebe	229	6	hospitalised	hospitalise	VBN
cord-345472-qrddwebe	229	7	with	with	IN
cord-345472-qrddwebe	229	8	RSV	RSV	NNP
cord-345472-qrddwebe	229	9	bronchiolitis	bronchiolitis	NNP
cord-345472-qrddwebe	229	10	demonstrated	demonstrate	VBD
cord-345472-qrddwebe	229	11	that	that	IN
cord-345472-qrddwebe	229	12	,	,	,
cord-345472-qrddwebe	229	13	compared	compare	VBN
cord-345472-qrddwebe	229	14	with	with	IN
cord-345472-qrddwebe	229	15	the	the	DT
cord-345472-qrddwebe	229	16	placebo	placebo	NN
cord-345472-qrddwebe	229	17	-	-	HYPH
cord-345472-qrddwebe	229	18	control	control	NN
cord-345472-qrddwebe	229	19	group	group	NN
cord-345472-qrddwebe	229	20	,	,	,
cord-345472-qrddwebe	229	21	a	a	DT
cord-345472-qrddwebe	229	22	14-day	14-day	CD
cord-345472-qrddwebe	229	23	treatment	treatment	NN
cord-345472-qrddwebe	229	24	with	with	IN
cord-345472-qrddwebe	229	25	azithromycin	azithromycin	NNP
cord-345472-qrddwebe	229	26	significantly	significantly	RB
cord-345472-qrddwebe	229	27	decreased	decrease	VBD
cord-345472-qrddwebe	229	28	wheezing	wheezing	JJ
cord-345472-qrddwebe	229	29	episodes	episode	NNS
cord-345472-qrddwebe	229	30	,	,	,
cord-345472-qrddwebe	229	31	time	time	NN
cord-345472-qrddwebe	229	32	to	to	IN
cord-345472-qrddwebe	229	33	recovery	recovery	NN
cord-345472-qrddwebe	229	34	,	,	,
cord-345472-qrddwebe	229	35	and	and	CC
cord-345472-qrddwebe	229	36	overall	overall	JJ
cord-345472-qrddwebe	229	37	respiratory	respiratory	JJ
cord-345472-qrddwebe	229	38	morbidity	morbidity	NN
cord-345472-qrddwebe	229	39	over	over	IN
cord-345472-qrddwebe	229	40	the	the	DT
cord-345472-qrddwebe	229	41	subsequent	subsequent	JJ
cord-345472-qrddwebe	229	42	year	year	NN
cord-345472-qrddwebe	229	43	in	in	IN
cord-345472-qrddwebe	229	44	comparison	comparison	NN
cord-345472-qrddwebe	229	45	[	[	-LRB-
cord-345472-qrddwebe	229	46	88	88	CD
cord-345472-qrddwebe	229	47	]	]	-RRB-
cord-345472-qrddwebe	229	48	.	.	.
cord-345472-qrddwebe	230	1	Notably	notably	RB
cord-345472-qrddwebe	230	2	,	,	,
cord-345472-qrddwebe	230	3	this	this	DT
cord-345472-qrddwebe	230	4	was	be	VBD
cord-345472-qrddwebe	230	5	associated	associate	VBN
cord-345472-qrddwebe	230	6	with	with	IN
cord-345472-qrddwebe	230	7	lower	low	JJR
cord-345472-qrddwebe	230	8	IL-8	il-8	NN
cord-345472-qrddwebe	230	9	levels	level	NNS
cord-345472-qrddwebe	230	10	in	in	IN
cord-345472-qrddwebe	230	11	nasal	nasal	NN
cord-345472-qrddwebe	230	12	lavage	lavage	NN
cord-345472-qrddwebe	230	13	fluid	fluid	NN
cord-345472-qrddwebe	230	14	,	,	,
cord-345472-qrddwebe	230	15	suggesting	suggest	VBG
cord-345472-qrddwebe	230	16	that	that	IN
cord-345472-qrddwebe	230	17	neutrophil	neutrophil	NN
cord-345472-qrddwebe	230	18	numbers	number	NNS
cord-345472-qrddwebe	230	19	were	be	VBD
cord-345472-qrddwebe	230	20	attenuated	attenuate	VBN
cord-345472-qrddwebe	230	21	,	,	,
cord-345472-qrddwebe	230	22	although	although	IN
cord-345472-qrddwebe	230	23	this	this	DT
cord-345472-qrddwebe	230	24	was	be	VBD
cord-345472-qrddwebe	230	25	not	not	RB
cord-345472-qrddwebe	230	26	specifically	specifically	RB
cord-345472-qrddwebe	230	27	assessed	assess	VBN
cord-345472-qrddwebe	230	28	[	[	-LRB-
cord-345472-qrddwebe	230	29	88	88	CD
cord-345472-qrddwebe	230	30	]	]	-RRB-
cord-345472-qrddwebe	230	31	.	.	.
cord-345472-qrddwebe	231	1	Preclinical	preclinical	JJ
cord-345472-qrddwebe	231	2	studies	study	NNS
cord-345472-qrddwebe	231	3	in	in	IN
cord-345472-qrddwebe	231	4	mice	mouse	NNS
cord-345472-qrddwebe	231	5	have	have	VBP
cord-345472-qrddwebe	231	6	also	also	RB
cord-345472-qrddwebe	231	7	demonstrated	demonstrate	VBN
cord-345472-qrddwebe	231	8	that	that	IN
cord-345472-qrddwebe	231	9	azithromycin	azithromycin	NNP
cord-345472-qrddwebe	231	10	decreases	decrease	VBZ
cord-345472-qrddwebe	231	11	virus	virus	NN
cord-345472-qrddwebe	231	12	-	-	HYPH
cord-345472-qrddwebe	231	13	induced	induce	VBN
cord-345472-qrddwebe	231	14	neutrophil	neutrophil	NN
cord-345472-qrddwebe	231	15	accumulation	accumulation	NN
cord-345472-qrddwebe	231	16	in	in	IN
cord-345472-qrddwebe	231	17	the	the	DT
cord-345472-qrddwebe	231	18	lung	lung	NN
cord-345472-qrddwebe	231	19	by	by	IN
cord-345472-qrddwebe	231	20	abrogating	abrogate	VBG
cord-345472-qrddwebe	231	21	the	the	DT
cord-345472-qrddwebe	231	22	expression	expression	NN
cord-345472-qrddwebe	231	23	of	of	IN
cord-345472-qrddwebe	231	24	neutrophil	neutrophil	NN
cord-345472-qrddwebe	231	25	inflammatory	inflammatory	JJ
cord-345472-qrddwebe	231	26	mediators	mediator	NNS
cord-345472-qrddwebe	231	27	such	such	JJ
cord-345472-qrddwebe	231	28	as	as	IN
cord-345472-qrddwebe	231	29	CXCL1	CXCL1	NNP
cord-345472-qrddwebe	231	30	[	[	-LRB-
cord-345472-qrddwebe	231	31	136	136	CD
cord-345472-qrddwebe	231	32	]	]	-RRB-
cord-345472-qrddwebe	231	33	.	.	.
cord-345472-qrddwebe	232	1	In	in	IN
cord-345472-qrddwebe	232	2	a	a	DT
cord-345472-qrddwebe	232	3	follow	follow	NN
cord-345472-qrddwebe	232	4	-	-	HYPH
cord-345472-qrddwebe	232	5	up	up	NN
cord-345472-qrddwebe	232	6	study	study	NN
cord-345472-qrddwebe	232	7	to	to	IN
cord-345472-qrddwebe	232	8	the	the	DT
cord-345472-qrddwebe	232	9	clinical	clinical	JJ
cord-345472-qrddwebe	232	10	trial	trial	NN
cord-345472-qrddwebe	232	11	,	,	,
cord-345472-qrddwebe	232	12	azithromycin	azithromycin	NNP
cord-345472-qrddwebe	232	13	treatment	treatment	NN
cord-345472-qrddwebe	232	14	modified	modify	VBD
cord-345472-qrddwebe	232	15	the	the	DT
cord-345472-qrddwebe	232	16	composition	composition	NN
cord-345472-qrddwebe	232	17	of	of	IN
cord-345472-qrddwebe	232	18	the	the	DT
cord-345472-qrddwebe	232	19	upper	upper	JJ
cord-345472-qrddwebe	232	20	airway	airway	NN
cord-345472-qrddwebe	232	21	microbiome	microbiome	NN
cord-345472-qrddwebe	232	22	,	,	,
cord-345472-qrddwebe	232	23	reducing	reduce	VBG
cord-345472-qrddwebe	232	24	the	the	DT
cord-345472-qrddwebe	232	25	abundance	abundance	NN
cord-345472-qrddwebe	232	26	of	of	IN
cord-345472-qrddwebe	232	27	Moraxella	Moraxella	NNP
cord-345472-qrddwebe	232	28	[	[	-LRB-
cord-345472-qrddwebe	232	29	138	138	CD
cord-345472-qrddwebe	232	30	]	]	-RRB-
cord-345472-qrddwebe	232	31	.	.	.
cord-345472-qrddwebe	233	1	This	this	DT
cord-345472-qrddwebe	233	2	phenotype	phenotype	NN
cord-345472-qrddwebe	233	3	was	be	VBD
cord-345472-qrddwebe	233	4	associated	associate	VBN
cord-345472-qrddwebe	233	5	with	with	IN
cord-345472-qrddwebe	233	6	lower	low	JJR
cord-345472-qrddwebe	233	7	odds	odd	NNS
cord-345472-qrddwebe	233	8	of	of	IN
cord-345472-qrddwebe	233	9	developing	develop	VBG
cord-345472-qrddwebe	233	10	recurrent	recurrent	JJ
cord-345472-qrddwebe	233	11	wheezing	wheeze	VBG
cord-345472-qrddwebe	233	12	episodes	episode	NNS
cord-345472-qrddwebe	233	13	over	over	IN
cord-345472-qrddwebe	233	14	the	the	DT
cord-345472-qrddwebe	233	15	next	next	JJ
cord-345472-qrddwebe	233	16	12	12	CD
cord-345472-qrddwebe	233	17	months	month	NNS
cord-345472-qrddwebe	233	18	[	[	-LRB-
cord-345472-qrddwebe	233	19	138	138	CD
cord-345472-qrddwebe	233	20	]	]	-RRB-
cord-345472-qrddwebe	233	21	.	.	.
cord-345472-qrddwebe	234	1	Ongoing	ongoing	JJ
cord-345472-qrddwebe	234	2	phase	phase	NN
cord-345472-qrddwebe	234	3	II	ii	CD
cord-345472-qrddwebe	234	4	clinical	clinical	JJ
cord-345472-qrddwebe	234	5	trials	trial	NNS
cord-345472-qrddwebe	234	6	are	be	VBP
cord-345472-qrddwebe	234	7	evaluating	evaluate	VBG
cord-345472-qrddwebe	234	8	whether	whether	IN
cord-345472-qrddwebe	234	9	the	the	DT
cord-345472-qrddwebe	234	10	addition	addition	NN
cord-345472-qrddwebe	234	11	of	of	IN
cord-345472-qrddwebe	234	12	azithromycin	azithromycin	NNP
cord-345472-qrddwebe	234	13	to	to	IN
cord-345472-qrddwebe	234	14	routine	routine	JJ
cord-345472-qrddwebe	234	15	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	234	16	care	care	NN
cord-345472-qrddwebe	234	17	in	in	IN
cord-345472-qrddwebe	234	18	hospitalised	hospitalise	VBN
cord-345472-qrddwebe	234	19	infants	infant	NNS
cord-345472-qrddwebe	234	20	reduces	reduce	VBZ
cord-345472-qrddwebe	234	21	the	the	DT
cord-345472-qrddwebe	234	22	frequency	frequency	NN
cord-345472-qrddwebe	234	23	of	of	IN
cord-345472-qrddwebe	234	24	recurrent	recurrent	JJ
cord-345472-qrddwebe	234	25	wheeze	wheeze	NN
cord-345472-qrddwebe	234	26	episodes	episode	NNS
cord-345472-qrddwebe	234	27	during	during	IN
cord-345472-qrddwebe	234	28	preschool	preschool	NN
cord-345472-qrddwebe	234	29	years	year	NNS
cord-345472-qrddwebe	235	1	(	(	-LRB-
cord-345472-qrddwebe	235	2	ClinicalTrials.gov	ClinicalTrials.gov	NNP
cord-345472-qrddwebe	235	3	identifier	identifier	NN
cord-345472-qrddwebe	235	4	:	:	:
cord-345472-qrddwebe	235	5	NCT01486758	NCT01486758	NNP
cord-345472-qrddwebe	235	6	)	)	-RRB-
cord-345472-qrddwebe	235	7	.	.	.
cord-345472-qrddwebe	236	1	Viruses	virus	NNS
cord-345472-qrddwebe	236	2	2020	2020	CD
cord-345472-qrddwebe	236	3	,	,	,
cord-345472-qrddwebe	236	4	12	12	CD
cord-345472-qrddwebe	236	5	,	,	,
cord-345472-qrddwebe	236	6	x	x	NN
cord-345472-qrddwebe	237	1	FOR	for	IN
cord-345472-qrddwebe	237	2	PEER	PEER	NNP
cord-345472-qrddwebe	237	3	REVIEW	REVIEW	NNP
cord-345472-qrddwebe	237	4	10	10	CD
cord-345472-qrddwebe	237	5	of	of	IN
cord-345472-qrddwebe	237	6	20	20	CD
cord-345472-qrddwebe	237	7	would	would	MD
cord-345472-qrddwebe	237	8	help	help	VB
cord-345472-qrddwebe	237	9	address	address	VB
cord-345472-qrddwebe	237	10	this	this	DT
cord-345472-qrddwebe	237	11	question	question	NN
cord-345472-qrddwebe	237	12	.	.	.
cord-345472-qrddwebe	238	1	In	in	IN
cord-345472-qrddwebe	238	2	summary	summary	NN
cord-345472-qrddwebe	238	3	,	,	,
cord-345472-qrddwebe	238	4	severe	severe	JJ
cord-345472-qrddwebe	238	5	neutrophilia	neutrophilia	NNP
cord-345472-qrddwebe	238	6	and	and	CC
cord-345472-qrddwebe	238	7	excessive	excessive	JJ
cord-345472-qrddwebe	238	8	production	production	NN
cord-345472-qrddwebe	238	9	of	of	IN
cord-345472-qrddwebe	238	10	powerful	powerful	JJ
cord-345472-qrddwebe	238	11	antimicrobial	antimicrobial	JJ
cord-345472-qrddwebe	238	12	mediators	mediator	NNS
cord-345472-qrddwebe	238	13	appears	appear	VBZ
cord-345472-qrddwebe	238	14	to	to	TO
cord-345472-qrddwebe	238	15	cause	cause	VB
cord-345472-qrddwebe	238	16	significant	significant	JJ
cord-345472-qrddwebe	238	17	collateral	collateral	JJ
cord-345472-qrddwebe	238	18	damage	damage	NN
cord-345472-qrddwebe	238	19	,	,	,
cord-345472-qrddwebe	238	20	resulting	result	VBG
cord-345472-qrddwebe	238	21	in	in	IN
cord-345472-qrddwebe	238	22	airway	airway	NN
cord-345472-qrddwebe	238	23	obstruction	obstruction	NN
cord-345472-qrddwebe	238	24	and	and	CC
cord-345472-qrddwebe	238	25	the	the	DT
cord-345472-qrddwebe	238	26	clinical	clinical	JJ
cord-345472-qrddwebe	238	27	symptoms	symptom	NNS
cord-345472-qrddwebe	238	28	that	that	WDT
cord-345472-qrddwebe	238	29	characterise	characterise	VBP
cord-345472-qrddwebe	238	30	severe	severe	JJ
cord-345472-qrddwebe	238	31	RSV	RSV	NNP
cord-345472-qrddwebe	238	32	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	238	33	.	.	.
cord-345472-qrddwebe	239	1	Pharmacological	pharmacological	JJ
cord-345472-qrddwebe	239	2	tools	tool	NNS
cord-345472-qrddwebe	239	3	to	to	TO
cord-345472-qrddwebe	239	4	inhibit	inhibit	VB
cord-345472-qrddwebe	239	5	the	the	DT
cord-345472-qrddwebe	239	6	excessive	excessive	JJ
cord-345472-qrddwebe	239	7	neutrophilic	neutrophilic	JJ
cord-345472-qrddwebe	239	8	response	response	NN
cord-345472-qrddwebe	239	9	in	in	IN
cord-345472-qrddwebe	239	10	the	the	DT
cord-345472-qrddwebe	239	11	lung	lung	NN
cord-345472-qrddwebe	239	12	are	be	VBP
cord-345472-qrddwebe	239	13	likely	likely	JJ
cord-345472-qrddwebe	239	14	to	to	TO
cord-345472-qrddwebe	239	15	ameliorate	ameliorate	VB
cord-345472-qrddwebe	239	16	the	the	DT
cord-345472-qrddwebe	239	17	severity	severity	NN
cord-345472-qrddwebe	239	18	of	of	IN
cord-345472-qrddwebe	239	19	RSV	RSV	NNP
cord-345472-qrddwebe	239	20	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	239	21	.	.	.
cord-345472-qrddwebe	240	1	To	to	TO
cord-345472-qrddwebe	240	2	achieve	achieve	VB
cord-345472-qrddwebe	240	3	this	this	DT
cord-345472-qrddwebe	240	4	goal	goal	NN
cord-345472-qrddwebe	240	5	,	,	,
cord-345472-qrddwebe	240	6	therapeutic	therapeutic	JJ
cord-345472-qrddwebe	240	7	strategies	strategy	NNS
cord-345472-qrddwebe	240	8	should	should	MD
cord-345472-qrddwebe	240	9	seek	seek	VB
cord-345472-qrddwebe	240	10	to	to	TO
cord-345472-qrddwebe	240	11	modify	modify	VB
cord-345472-qrddwebe	240	12	the	the	DT
cord-345472-qrddwebe	240	13	expression	expression	NN
cord-345472-qrddwebe	240	14	of	of	IN
cord-345472-qrddwebe	240	15	cytokines	cytokine	NNS
cord-345472-qrddwebe	240	16	and/or	and/or	CC
cord-345472-qrddwebe	240	17	chemokines	chemokine	NNS
cord-345472-qrddwebe	240	18	,	,	,
cord-345472-qrddwebe	240	19	which	which	WDT
cord-345472-qrddwebe	240	20	regulate	regulate	VBP
cord-345472-qrddwebe	240	21	neutrophil	neutrophil	NN
cord-345472-qrddwebe	240	22	trafficking	trafficking	NN
cord-345472-qrddwebe	240	23	/	/	SYM
cord-345472-qrddwebe	240	24	recruitment	recruitment	NN
cord-345472-qrddwebe	240	25	into	into	IN
cord-345472-qrddwebe	240	26	the	the	DT
cord-345472-qrddwebe	240	27	lung	lung	NN
cord-345472-qrddwebe	240	28	,	,	,
cord-345472-qrddwebe	240	29	and	and	CC
cord-345472-qrddwebe	240	30	neutrophil	neutrophil	NN
cord-345472-qrddwebe	240	31	activation	activation	NN
cord-345472-qrddwebe	240	32	and	and	CC
cord-345472-qrddwebe	240	33	function	function	NN
cord-345472-qrddwebe	240	34	in	in	IN
cord-345472-qrddwebe	240	35	response	response	NN
cord-345472-qrddwebe	240	36	to	to	IN
cord-345472-qrddwebe	240	37	infection	infection	NN
cord-345472-qrddwebe	240	38	(	(	-LRB-
cord-345472-qrddwebe	240	39	as	as	IN
cord-345472-qrddwebe	240	40	proposed	propose	VBN
cord-345472-qrddwebe	240	41	in	in	IN
cord-345472-qrddwebe	240	42	Figure	figure	NN
cord-345472-qrddwebe	240	43	2	2	CD
cord-345472-qrddwebe	240	44	)	)	-RRB-
cord-345472-qrddwebe	240	45	.	.	.
cord-345472-qrddwebe	241	1	Macrolide	macrolide	JJ
cord-345472-qrddwebe	241	2	antibiotics	antibiotic	NNS
cord-345472-qrddwebe	241	3	,	,	,
cord-345472-qrddwebe	241	4	in	in	IN
cord-345472-qrddwebe	241	5	particular	particular	JJ
cord-345472-qrddwebe	241	6	azithromycin	azithromycin	NN
cord-345472-qrddwebe	241	7	,	,	,
cord-345472-qrddwebe	241	8	which	which	WDT
cord-345472-qrddwebe	241	9	is	be	VBZ
cord-345472-qrddwebe	241	10	efficacious	efficacious	JJ
cord-345472-qrddwebe	241	11	against	against	IN
cord-345472-qrddwebe	241	12	IL-8	il-8	NN
cord-345472-qrddwebe	241	13	and	and	CC
cord-345472-qrddwebe	241	14	neutrophil	neutrophil	NN
cord-345472-qrddwebe	241	15	-	-	HYPH
cord-345472-qrddwebe	241	16	induced	induce	VBN
cord-345472-qrddwebe	241	17	inflammation	inflammation	NN
cord-345472-qrddwebe	241	18	,	,	,
cord-345472-qrddwebe	241	19	decrease	decrease	VB
cord-345472-qrddwebe	241	20	the	the	DT
cord-345472-qrddwebe	241	21	severity	severity	NN
cord-345472-qrddwebe	241	22	of	of	IN
cord-345472-qrddwebe	241	23	symptoms	symptom	NNS
cord-345472-qrddwebe	241	24	during	during	IN
cord-345472-qrddwebe	241	25	viral	viral	JJ
cord-345472-qrddwebe	241	26	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	241	27	[	[	-LRB-
cord-345472-qrddwebe	241	28	88	88	CD
cord-345472-qrddwebe	241	29	,	,	,
cord-345472-qrddwebe	241	30	136	136	CD
cord-345472-qrddwebe	241	31	,	,	,
cord-345472-qrddwebe	241	32	137	137	CD
cord-345472-qrddwebe	241	33	]	]	-RRB-
cord-345472-qrddwebe	241	34	.	.	.
cord-345472-qrddwebe	242	1	A	a	DT
cord-345472-qrddwebe	242	2	randomised	randomised	JJ
cord-345472-qrddwebe	242	3	trial	trial	NN
cord-345472-qrddwebe	242	4	in	in	IN
cord-345472-qrddwebe	242	5	infants	infant	NNS
cord-345472-qrddwebe	242	6	hospitalised	hospitalise	VBN
cord-345472-qrddwebe	242	7	with	with	IN
cord-345472-qrddwebe	242	8	RSV	RSV	NNP
cord-345472-qrddwebe	242	9	bronchiolitis	bronchiolitis	NNP
cord-345472-qrddwebe	242	10	demonstrated	demonstrate	VBD
cord-345472-qrddwebe	242	11	that	that	IN
cord-345472-qrddwebe	242	12	,	,	,
cord-345472-qrddwebe	242	13	compared	compare	VBN
cord-345472-qrddwebe	242	14	with	with	IN
cord-345472-qrddwebe	242	15	the	the	DT
cord-345472-qrddwebe	242	16	placebo	placebo	NN
cord-345472-qrddwebe	242	17	-	-	HYPH
cord-345472-qrddwebe	242	18	control	control	NN
cord-345472-qrddwebe	242	19	group	group	NN
cord-345472-qrddwebe	242	20	,	,	,
cord-345472-qrddwebe	242	21	a	a	DT
cord-345472-qrddwebe	242	22	14-day	14-day	CD
cord-345472-qrddwebe	242	23	treatment	treatment	NN
cord-345472-qrddwebe	242	24	with	with	IN
cord-345472-qrddwebe	242	25	azithromycin	azithromycin	NNP
cord-345472-qrddwebe	242	26	significantly	significantly	RB
cord-345472-qrddwebe	242	27	decreased	decrease	VBD
cord-345472-qrddwebe	242	28	wheezing	wheezing	JJ
cord-345472-qrddwebe	242	29	episodes	episode	NNS
cord-345472-qrddwebe	242	30	,	,	,
cord-345472-qrddwebe	242	31	time	time	NN
cord-345472-qrddwebe	242	32	to	to	IN
cord-345472-qrddwebe	242	33	recovery	recovery	NN
cord-345472-qrddwebe	242	34	,	,	,
cord-345472-qrddwebe	242	35	and	and	CC
cord-345472-qrddwebe	242	36	overall	overall	JJ
cord-345472-qrddwebe	242	37	respiratory	respiratory	JJ
cord-345472-qrddwebe	242	38	morbidity	morbidity	NN
cord-345472-qrddwebe	242	39	over	over	IN
cord-345472-qrddwebe	242	40	the	the	DT
cord-345472-qrddwebe	242	41	subsequent	subsequent	JJ
cord-345472-qrddwebe	242	42	year	year	NN
cord-345472-qrddwebe	242	43	in	in	IN
cord-345472-qrddwebe	242	44	comparison	comparison	NN
cord-345472-qrddwebe	242	45	[	[	-LRB-
cord-345472-qrddwebe	242	46	88	88	CD
cord-345472-qrddwebe	242	47	]	]	-RRB-
cord-345472-qrddwebe	242	48	.	.	.
cord-345472-qrddwebe	243	1	Notably	notably	RB
cord-345472-qrddwebe	243	2	,	,	,
cord-345472-qrddwebe	243	3	this	this	DT
cord-345472-qrddwebe	243	4	was	be	VBD
cord-345472-qrddwebe	243	5	associated	associate	VBN
cord-345472-qrddwebe	243	6	with	with	IN
cord-345472-qrddwebe	243	7	lower	low	JJR
cord-345472-qrddwebe	243	8	IL-8	il-8	NN
cord-345472-qrddwebe	243	9	levels	level	NNS
cord-345472-qrddwebe	243	10	in	in	IN
cord-345472-qrddwebe	243	11	nasal	nasal	NN
cord-345472-qrddwebe	243	12	lavage	lavage	NN
cord-345472-qrddwebe	243	13	fluid	fluid	NN
cord-345472-qrddwebe	243	14	,	,	,
cord-345472-qrddwebe	243	15	suggesting	suggest	VBG
cord-345472-qrddwebe	243	16	that	that	IN
cord-345472-qrddwebe	243	17	neutrophil	neutrophil	NN
cord-345472-qrddwebe	243	18	numbers	number	NNS
cord-345472-qrddwebe	243	19	were	be	VBD
cord-345472-qrddwebe	243	20	attenuated	attenuate	VBN
cord-345472-qrddwebe	243	21	,	,	,
cord-345472-qrddwebe	243	22	although	although	IN
cord-345472-qrddwebe	243	23	this	this	DT
cord-345472-qrddwebe	243	24	was	be	VBD
cord-345472-qrddwebe	243	25	not	not	RB
cord-345472-qrddwebe	243	26	specifically	specifically	RB
cord-345472-qrddwebe	243	27	assessed	assess	VBN
cord-345472-qrddwebe	243	28	[	[	-LRB-
cord-345472-qrddwebe	243	29	88	88	CD
cord-345472-qrddwebe	243	30	]	]	-RRB-
cord-345472-qrddwebe	243	31	.	.	.
cord-345472-qrddwebe	244	1	Preclinical	preclinical	JJ
cord-345472-qrddwebe	244	2	studies	study	NNS
cord-345472-qrddwebe	244	3	in	in	IN
cord-345472-qrddwebe	244	4	mice	mouse	NNS
cord-345472-qrddwebe	244	5	have	have	VBP
cord-345472-qrddwebe	244	6	also	also	RB
cord-345472-qrddwebe	244	7	demonstrated	demonstrate	VBN
cord-345472-qrddwebe	244	8	that	that	IN
cord-345472-qrddwebe	244	9	azithromycin	azithromycin	NNP
cord-345472-qrddwebe	244	10	decreases	decrease	VBZ
cord-345472-qrddwebe	244	11	virusinduced	virusinduce	VBN
cord-345472-qrddwebe	244	12	neutrophil	neutrophil	NN
cord-345472-qrddwebe	244	13	accumulation	accumulation	NN
cord-345472-qrddwebe	244	14	in	in	IN
cord-345472-qrddwebe	244	15	the	the	DT
cord-345472-qrddwebe	244	16	lung	lung	NN
cord-345472-qrddwebe	244	17	by	by	IN
cord-345472-qrddwebe	244	18	abrogating	abrogate	VBG
cord-345472-qrddwebe	244	19	the	the	DT
cord-345472-qrddwebe	244	20	expression	expression	NN
cord-345472-qrddwebe	244	21	of	of	IN
cord-345472-qrddwebe	244	22	neutrophil	neutrophil	NN
cord-345472-qrddwebe	244	23	inflammatory	inflammatory	JJ
cord-345472-qrddwebe	244	24	mediators	mediator	NNS
cord-345472-qrddwebe	244	25	such	such	JJ
cord-345472-qrddwebe	244	26	as	as	IN
cord-345472-qrddwebe	244	27	CXCL1	CXCL1	NNP
cord-345472-qrddwebe	244	28	[	[	-LRB-
cord-345472-qrddwebe	244	29	136	136	CD
cord-345472-qrddwebe	244	30	]	]	-RRB-
cord-345472-qrddwebe	244	31	.	.	.
cord-345472-qrddwebe	245	1	In	in	IN
cord-345472-qrddwebe	245	2	a	a	DT
cord-345472-qrddwebe	245	3	follow	follow	NN
cord-345472-qrddwebe	245	4	-	-	HYPH
cord-345472-qrddwebe	245	5	up	up	NN
cord-345472-qrddwebe	245	6	study	study	NN
cord-345472-qrddwebe	245	7	to	to	IN
cord-345472-qrddwebe	245	8	the	the	DT
cord-345472-qrddwebe	245	9	clinical	clinical	JJ
cord-345472-qrddwebe	245	10	trial	trial	NN
cord-345472-qrddwebe	245	11	,	,	,
cord-345472-qrddwebe	245	12	azithromycin	azithromycin	NNP
cord-345472-qrddwebe	245	13	treatment	treatment	NN
cord-345472-qrddwebe	245	14	modified	modify	VBD
cord-345472-qrddwebe	245	15	the	the	DT
cord-345472-qrddwebe	245	16	composition	composition	NN
cord-345472-qrddwebe	245	17	of	of	IN
cord-345472-qrddwebe	245	18	the	the	DT
cord-345472-qrddwebe	245	19	upper	upper	JJ
cord-345472-qrddwebe	245	20	airway	airway	NN
cord-345472-qrddwebe	245	21	microbiome	microbiome	NN
cord-345472-qrddwebe	245	22	,	,	,
cord-345472-qrddwebe	245	23	reducing	reduce	VBG
cord-345472-qrddwebe	245	24	the	the	DT
cord-345472-qrddwebe	245	25	abundance	abundance	NN
cord-345472-qrddwebe	245	26	of	of	IN
cord-345472-qrddwebe	245	27	Moraxella	Moraxella	NNP
cord-345472-qrddwebe	245	28	[	[	-LRB-
cord-345472-qrddwebe	245	29	138	138	CD
cord-345472-qrddwebe	245	30	]	]	-RRB-
cord-345472-qrddwebe	245	31	.	.	.
cord-345472-qrddwebe	246	1	This	this	DT
cord-345472-qrddwebe	246	2	phenotype	phenotype	NN
cord-345472-qrddwebe	246	3	was	be	VBD
cord-345472-qrddwebe	246	4	associated	associate	VBN
cord-345472-qrddwebe	246	5	with	with	IN
cord-345472-qrddwebe	246	6	lower	low	JJR
cord-345472-qrddwebe	246	7	odds	odd	NNS
cord-345472-qrddwebe	246	8	of	of	IN
cord-345472-qrddwebe	246	9	developing	develop	VBG
cord-345472-qrddwebe	246	10	recurrent	recurrent	JJ
cord-345472-qrddwebe	246	11	wheezing	wheeze	VBG
cord-345472-qrddwebe	246	12	episodes	episode	NNS
cord-345472-qrddwebe	246	13	over	over	IN
cord-345472-qrddwebe	246	14	the	the	DT
cord-345472-qrddwebe	246	15	next	next	JJ
cord-345472-qrddwebe	246	16	12	12	CD
cord-345472-qrddwebe	246	17	months	month	NNS
cord-345472-qrddwebe	246	18	[	[	-LRB-
cord-345472-qrddwebe	246	19	138	138	CD
cord-345472-qrddwebe	246	20	]	]	-RRB-
cord-345472-qrddwebe	246	21	.	.	.
cord-345472-qrddwebe	247	1	Ongoing	ongoing	JJ
cord-345472-qrddwebe	247	2	phase	phase	NN
cord-345472-qrddwebe	247	3	II	ii	CD
cord-345472-qrddwebe	247	4	clinical	clinical	JJ
cord-345472-qrddwebe	247	5	trials	trial	NNS
cord-345472-qrddwebe	247	6	are	be	VBP
cord-345472-qrddwebe	247	7	evaluating	evaluate	VBG
cord-345472-qrddwebe	247	8	whether	whether	IN
cord-345472-qrddwebe	247	9	the	the	DT
cord-345472-qrddwebe	247	10	addition	addition	NN
cord-345472-qrddwebe	247	11	of	of	IN
cord-345472-qrddwebe	247	12	azithromycin	azithromycin	NNP
cord-345472-qrddwebe	247	13	to	to	IN
cord-345472-qrddwebe	247	14	routine	routine	JJ
cord-345472-qrddwebe	247	15	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	247	16	care	care	NN
cord-345472-qrddwebe	247	17	in	in	IN
cord-345472-qrddwebe	247	18	hospitalised	hospitalise	VBN
cord-345472-qrddwebe	247	19	infants	infant	NNS
cord-345472-qrddwebe	247	20	reduces	reduce	VBZ
cord-345472-qrddwebe	247	21	the	the	DT
cord-345472-qrddwebe	247	22	frequency	frequency	NN
cord-345472-qrddwebe	247	23	of	of	IN
cord-345472-qrddwebe	247	24	recurrent	recurrent	JJ
cord-345472-qrddwebe	247	25	wheeze	wheeze	NN
cord-345472-qrddwebe	247	26	episodes	episode	NNS
cord-345472-qrddwebe	247	27	during	during	IN
cord-345472-qrddwebe	247	28	preschool	preschool	NN
cord-345472-qrddwebe	247	29	years	year	NNS
cord-345472-qrddwebe	248	1	(	(	-LRB-
cord-345472-qrddwebe	248	2	ClinicalTrials.gov	ClinicalTrials.gov	NNP
cord-345472-qrddwebe	248	3	identifier	identifier	NN
cord-345472-qrddwebe	248	4	:	:	:
cord-345472-qrddwebe	248	5	NCT01486758	NCT01486758	NNP
cord-345472-qrddwebe	248	6	)	)	-RRB-
cord-345472-qrddwebe	248	7	.	.	.
cord-345472-qrddwebe	249	1	Therapeutic	therapeutic	JJ
cord-345472-qrddwebe	249	2	inhibition	inhibition	NN
cord-345472-qrddwebe	249	3	strategies	strategy	NNS
cord-345472-qrddwebe	249	4	may	may	MD
cord-345472-qrddwebe	249	5	aim	aim	VB
cord-345472-qrddwebe	249	6	to	to	IN
cord-345472-qrddwebe	249	7	:	:	:
cord-345472-qrddwebe	249	8	(	(	-LRB-
cord-345472-qrddwebe	249	9	1	1	LS
cord-345472-qrddwebe	249	10	)	)	-RRB-
cord-345472-qrddwebe	249	11	block	block	VB
cord-345472-qrddwebe	249	12	excessive	excessive	JJ
cord-345472-qrddwebe	249	13	neutrophil	neutrophil	NN
cord-345472-qrddwebe	249	14	granulopoiesis	granulopoiesis	NN
cord-345472-qrddwebe	249	15	in	in	IN
cord-345472-qrddwebe	249	16	the	the	DT
cord-345472-qrddwebe	249	17	bone	bone	NN
cord-345472-qrddwebe	249	18	marrow	marrow	NN
cord-345472-qrddwebe	249	19	(	(	-LRB-
cord-345472-qrddwebe	249	20	e.g.	e.g.	RB
cord-345472-qrddwebe	249	21	,	,	,
cord-345472-qrddwebe	249	22	neutralising	neutralise	VBG
cord-345472-qrddwebe	249	23	G	G	NNP
cord-345472-qrddwebe	249	24	-	-	HYPH
cord-345472-qrddwebe	249	25	CSF	csf	NN
cord-345472-qrddwebe	249	26	production	production	NN
cord-345472-qrddwebe	249	27	and	and	CC
cord-345472-qrddwebe	249	28	function	function	NN
cord-345472-qrddwebe	249	29	)	)	-RRB-
cord-345472-qrddwebe	249	30	;	;	:
cord-345472-qrddwebe	249	31	(	(	-LRB-
cord-345472-qrddwebe	249	32	2	2	LS
cord-345472-qrddwebe	249	33	)	)	-RRB-
cord-345472-qrddwebe	249	34	antagonise	antagonise	VB
cord-345472-qrddwebe	249	35	chemokine	chemokine	NN
cord-345472-qrddwebe	249	36	-	-	HYPH
cord-345472-qrddwebe	249	37	mediated	mediate	VBN
cord-345472-qrddwebe	249	38	neutrophil	neutrophil	NN
cord-345472-qrddwebe	249	39	activation	activation	NN
cord-345472-qrddwebe	249	40	and	and	CC
cord-345472-qrddwebe	249	41	chemotaxis	chemotaxis	NN
cord-345472-qrddwebe	249	42	to	to	IN
cord-345472-qrddwebe	249	43	the	the	DT
cord-345472-qrddwebe	249	44	lung	lung	NN
cord-345472-qrddwebe	249	45	microenvironment	microenvironment	NN
cord-345472-qrddwebe	249	46	(	(	-LRB-
cord-345472-qrddwebe	249	47	e.g.	e.g.	RB
cord-345472-qrddwebe	249	48	,	,	,
cord-345472-qrddwebe	249	49	using	use	VBG
cord-345472-qrddwebe	249	50	CXCR2	CXCR2	NNS
cord-345472-qrddwebe	249	51	small	small	JJ
cord-345472-qrddwebe	249	52	molecule	molecule	NN
cord-345472-qrddwebe	249	53	inhibitors	inhibitor	NNS
cord-345472-qrddwebe	249	54	)	)	-RRB-
cord-345472-qrddwebe	249	55	;	;	:
cord-345472-qrddwebe	249	56	(	(	-LRB-
cord-345472-qrddwebe	249	57	3	3	LS
cord-345472-qrddwebe	249	58	)	)	-RRB-
cord-345472-qrddwebe	249	59	(	(	-LRB-
cord-345472-qrddwebe	249	60	4	4	LS
cord-345472-qrddwebe	249	61	)	)	-RRB-
cord-345472-qrddwebe	249	62	(	(	-LRB-
cord-345472-qrddwebe	249	63	5	5	LS
cord-345472-qrddwebe	249	64	)	)	-RRB-
cord-345472-qrddwebe	249	65	(	(	-LRB-
cord-345472-qrddwebe	249	66	6	6	LS
cord-345472-qrddwebe	249	67	)	)	-RRB-
cord-345472-qrddwebe	249	68	regulate	regulate	VB
cord-345472-qrddwebe	249	69	neutrophil	neutrophil	NN
cord-345472-qrddwebe	249	70	function	function	NN
cord-345472-qrddwebe	249	71	in	in	IN
cord-345472-qrddwebe	249	72	the	the	DT
cord-345472-qrddwebe	249	73	lung	lung	NN
cord-345472-qrddwebe	249	74	(	(	-LRB-
cord-345472-qrddwebe	249	75	e.g.	e.g.	RB
cord-345472-qrddwebe	249	76	,	,	,
cord-345472-qrddwebe	249	77	blocking	block	VBG
cord-345472-qrddwebe	249	78	the	the	DT
cord-345472-qrddwebe	249	79	production	production	NN
cord-345472-qrddwebe	249	80	of	of	IN
cord-345472-qrddwebe	249	81	antimicrobial	antimicrobial	JJ
cord-345472-qrddwebe	249	82	products	product	NNS
cord-345472-qrddwebe	249	83	such	such	JJ
cord-345472-qrddwebe	249	84	as	as	IN
cord-345472-qrddwebe	249	85	MMPs	mmp	NNS
cord-345472-qrddwebe	249	86	(	(	-LRB-
cord-345472-qrddwebe	249	87	3	3	CD
cord-345472-qrddwebe	249	88	)	)	-RRB-
cord-345472-qrddwebe	249	89	,	,	,
cord-345472-qrddwebe	249	90	ROS	ROS	NNP
cord-345472-qrddwebe	249	91	(	(	-LRB-
cord-345472-qrddwebe	249	92	4	4	CD
cord-345472-qrddwebe	249	93	)	)	-RRB-
cord-345472-qrddwebe	249	94	,	,	,
cord-345472-qrddwebe	249	95	inflammatory	inflammatory	JJ
cord-345472-qrddwebe	249	96	cytokines	cytokine	NNS
cord-345472-qrddwebe	249	97	(	(	-LRB-
cord-345472-qrddwebe	249	98	5	5	CD
cord-345472-qrddwebe	249	99	)	)	-RRB-
cord-345472-qrddwebe	249	100	,	,	,
cord-345472-qrddwebe	249	101	and	and	CC
cord-345472-qrddwebe	249	102	deposition	deposition	NN
cord-345472-qrddwebe	249	103	of	of	IN
cord-345472-qrddwebe	249	104	NETs	net	NNS
cord-345472-qrddwebe	249	105	(	(	-LRB-
cord-345472-qrddwebe	249	106	6	6	CD
cord-345472-qrddwebe	249	107	)	)	-RRB-
cord-345472-qrddwebe	249	108	)	)	-RRB-
cord-345472-qrddwebe	249	109	.	.	.
cord-345472-qrddwebe	250	1	Therapeutic	therapeutic	JJ
cord-345472-qrddwebe	250	2	anti	anti	JJ
cord-345472-qrddwebe	250	3	-	-	JJ
cord-345472-qrddwebe	250	4	viral	viral	JJ
cord-345472-qrddwebe	250	5	products	product	NNS
cord-345472-qrddwebe	250	6	(	(	-LRB-
cord-345472-qrddwebe	250	7	7	7	CD
cord-345472-qrddwebe	250	8	)	)	-RRB-
cord-345472-qrddwebe	250	9	may	may	MD
cord-345472-qrddwebe	250	10	also	also	RB
cord-345472-qrddwebe	250	11	limit	limit	VB
cord-345472-qrddwebe	250	12	RSV	RSV	NNP
cord-345472-qrddwebe	250	13	-	-	HYPH
cord-345472-qrddwebe	250	14	induced	induce	VBN
cord-345472-qrddwebe	250	15	recruitment	recruitment	NN
cord-345472-qrddwebe	250	16	of	of	IN
cord-345472-qrddwebe	250	17	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	250	18	in	in	IN
cord-345472-qrddwebe	250	19	the	the	DT
cord-345472-qrddwebe	250	20	lung	lung	NN
cord-345472-qrddwebe	250	21	during	during	IN
cord-345472-qrddwebe	250	22	infection	infection	NN
cord-345472-qrddwebe	250	23	.	.	.
cord-345472-qrddwebe	251	1	Targeting	target	VBG
cord-345472-qrddwebe	251	2	chemokine	chemokine	NN
cord-345472-qrddwebe	251	3	receptors	receptor	NNS
cord-345472-qrddwebe	251	4	,	,	,
cord-345472-qrddwebe	251	5	for	for	IN
cord-345472-qrddwebe	251	6	instance	instance	NN
cord-345472-qrddwebe	251	7	CXCR2	CXCR2	NNS
cord-345472-qrddwebe	251	8	,	,	,
cord-345472-qrddwebe	251	9	which	which	WDT
cord-345472-qrddwebe	251	10	is	be	VBZ
cord-345472-qrddwebe	251	11	important	important	JJ
cord-345472-qrddwebe	251	12	for	for	IN
cord-345472-qrddwebe	251	13	neutrophil	neutrophil	NN
cord-345472-qrddwebe	251	14	migration	migration	NN
cord-345472-qrddwebe	251	15	,	,	,
cord-345472-qrddwebe	251	16	may	may	MD
cord-345472-qrddwebe	251	17	also	also	RB
cord-345472-qrddwebe	251	18	be	be	VB
cord-345472-qrddwebe	251	19	a	a	DT
cord-345472-qrddwebe	251	20	therapeutic	therapeutic	JJ
cord-345472-qrddwebe	251	21	option	option	NN
cord-345472-qrddwebe	251	22	(	(	-LRB-
cord-345472-qrddwebe	251	23	Figure	figure	NN
cord-345472-qrddwebe	251	24	2	2	CD
cord-345472-qrddwebe	251	25	)	)	-RRB-
cord-345472-qrddwebe	251	26	.	.	.
cord-345472-qrddwebe	252	1	Danirixin	Danirixin	NNP
cord-345472-qrddwebe	252	2	,	,	,
cord-345472-qrddwebe	252	3	a	a	DT
cord-345472-qrddwebe	252	4	selective	selective	JJ
cord-345472-qrddwebe	252	5	and	and	CC
cord-345472-qrddwebe	252	6	reversible	reversible	JJ
cord-345472-qrddwebe	252	7	antagonist	antagonist	NN
cord-345472-qrddwebe	252	8	of	of	IN
cord-345472-qrddwebe	252	9	CXCR2	CXCR2	NNS
cord-345472-qrddwebe	252	10	,	,	,
cord-345472-qrddwebe	252	11	decreases	decrease	VBZ
cord-345472-qrddwebe	252	12	the	the	DT
cord-345472-qrddwebe	252	13	activation	activation	NN
cord-345472-qrddwebe	252	14	and	and	CC
cord-345472-qrddwebe	252	15	transmigration	transmigration	NN
cord-345472-qrddwebe	252	16	of	of	IN
cord-345472-qrddwebe	252	17	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	252	18	to	to	IN
cord-345472-qrddwebe	252	19	the	the	DT
cord-345472-qrddwebe	252	20	lungs	lung	NNS
cord-345472-qrddwebe	252	21	of	of	IN
cord-345472-qrddwebe	252	22	rats	rat	NNS
cord-345472-qrddwebe	252	23	treated	treat	VBN
cord-345472-qrddwebe	252	24	with	with	IN
cord-345472-qrddwebe	252	25	aerosolised	aerosolised	JJ
cord-345472-qrddwebe	252	26	lipopolysaccharide	lipopolysaccharide	NN
cord-345472-qrddwebe	252	27	[	[	-LRB-
cord-345472-qrddwebe	252	28	139	139	CD
cord-345472-qrddwebe	252	29	]	]	-RRB-
cord-345472-qrddwebe	252	30	.	.	.
cord-345472-qrddwebe	253	1	A	a	DT
cord-345472-qrddwebe	253	2	clinical	clinical	JJ
cord-345472-qrddwebe	253	3	trial	trial	NN
cord-345472-qrddwebe	253	4	to	to	TO
cord-345472-qrddwebe	253	5	evaluate	evaluate	VB
cord-345472-qrddwebe	253	6	the	the	DT
cord-345472-qrddwebe	253	7	efficacy	efficacy	NN
cord-345472-qrddwebe	253	8	of	of	IN
cord-345472-qrddwebe	253	9	Danirixin	Danirixin	NNP
cord-345472-qrddwebe	253	10	in	in	IN
cord-345472-qrddwebe	253	11	RSV	RSV	NNP
cord-345472-qrddwebe	253	12	-	-	HYPH
cord-345472-qrddwebe	253	13	infected	infect	VBN
cord-345472-qrddwebe	253	14	infants	infant	NNS
cord-345472-qrddwebe	253	15	<	<	XX
cord-345472-qrddwebe	253	16	2	2	CD
cord-345472-qrddwebe	253	17	years	year	NNS
cord-345472-qrddwebe	253	18	of	of	IN
cord-345472-qrddwebe	253	19	age	age	NN
cord-345472-qrddwebe	253	20	(	(	-LRB-
cord-345472-qrddwebe	253	21	ClinicalTrials.gov	ClinicalTrials.gov	NNP
cord-345472-qrddwebe	253	22	identifier	identifier	NN
cord-345472-qrddwebe	253	23	:	:	:
cord-345472-qrddwebe	253	24	NCT02201303	NCT02201303	NNP
cord-345472-qrddwebe	253	25	)	)	-RRB-
cord-345472-qrddwebe	253	26	is	be	VBZ
cord-345472-qrddwebe	253	27	ongoing	ongoing	JJ
cord-345472-qrddwebe	253	28	.	.	.
cord-345472-qrddwebe	254	1	Pharmacological	pharmacological	JJ
cord-345472-qrddwebe	254	2	inhibition	inhibition	NN
cord-345472-qrddwebe	254	3	of	of	IN
cord-345472-qrddwebe	254	4	MMP	MMP	NNP
cord-345472-qrddwebe	254	5	activity	activity	NN
cord-345472-qrddwebe	254	6	has	have	VBZ
cord-345472-qrddwebe	254	7	also	also	RB
cord-345472-qrddwebe	254	8	been	be	VBN
cord-345472-qrddwebe	254	9	employed	employ	VBN
cord-345472-qrddwebe	254	10	as	as	IN
cord-345472-qrddwebe	254	11	a	a	DT
cord-345472-qrddwebe	254	12	therapeutic	therapeutic	JJ
cord-345472-qrddwebe	254	13	strategy	strategy	NN
cord-345472-qrddwebe	254	14	for	for	IN
cord-345472-qrddwebe	254	15	treating	treat	VBG
cord-345472-qrddwebe	254	16	chronic	chronic	JJ
cord-345472-qrddwebe	254	17	lung	lung	NN
cord-345472-qrddwebe	254	18	diseases	disease	NNS
cord-345472-qrddwebe	254	19	[	[	-LRB-
cord-345472-qrddwebe	254	20	25	25	CD
cord-345472-qrddwebe	254	21	,	,	,
cord-345472-qrddwebe	254	22	140	140	CD
cord-345472-qrddwebe	254	23	,	,	,
cord-345472-qrddwebe	254	24	141	141	CD
cord-345472-qrddwebe	254	25	]	]	-RRB-
cord-345472-qrddwebe	254	26	.	.	.
cord-345472-qrddwebe	255	1	For	for	IN
cord-345472-qrddwebe	255	2	example	example	NN
cord-345472-qrddwebe	255	3	,	,	,
cord-345472-qrddwebe	255	4	marimastat	marimastat	NNP
cord-345472-qrddwebe	255	5	,	,	,
cord-345472-qrddwebe	255	6	a	a	DT
cord-345472-qrddwebe	255	7	broad	broad	JJ
cord-345472-qrddwebe	255	8	-	-	HYPH
cord-345472-qrddwebe	255	9	spectrum	spectrum	NN
cord-345472-qrddwebe	255	10	MMP	MMP	NNP
cord-345472-qrddwebe	255	11	inhibitor	inhibitor	NN
cord-345472-qrddwebe	255	12	,	,	,
cord-345472-qrddwebe	255	13	reduces	reduce	VBZ
cord-345472-qrddwebe	255	14	bronchial	bronchial	JJ
cord-345472-qrddwebe	255	15	hyperresponsiveness	hyperresponsiveness	NN
cord-345472-qrddwebe	255	16	to	to	IN
cord-345472-qrddwebe	255	17	inhaled	inhale	VBN
cord-345472-qrddwebe	255	18	allergens	allergen	NNS
cord-345472-qrddwebe	255	19	in	in	IN
cord-345472-qrddwebe	255	20	atopic	atopic	JJ
cord-345472-qrddwebe	255	21	asthmatic	asthmatic	JJ
cord-345472-qrddwebe	255	22	individuals	individual	NNS
cord-345472-qrddwebe	255	23	[	[	-LRB-
cord-345472-qrddwebe	255	24	140	140	CD
cord-345472-qrddwebe	255	25	]	]	-RRB-
cord-345472-qrddwebe	255	26	.	.	.
cord-345472-qrddwebe	256	1	Similarly	similarly	RB
cord-345472-qrddwebe	256	2	,	,	,
cord-345472-qrddwebe	256	3	mice	mouse	NNS
cord-345472-qrddwebe	256	4	treated	treat	VBN
cord-345472-qrddwebe	256	5	with	with	IN
cord-345472-qrddwebe	256	6	another	another	DT
cord-345472-qrddwebe	256	7	broad	broad	JJ
cord-345472-qrddwebe	256	8	-	-	HYPH
cord-345472-qrddwebe	256	9	spectrum	spectrum	NN
cord-345472-qrddwebe	256	10	MMP	MMP	NNP
cord-345472-qrddwebe	256	11	inhibitor	inhibitor	NN
cord-345472-qrddwebe	256	12	,	,	,
cord-345472-qrddwebe	256	13	R-94138	r-94138	CD
cord-345472-qrddwebe	256	14	,	,	,
cord-345472-qrddwebe	256	15	also	also	RB
cord-345472-qrddwebe	256	16	exhibited	exhibit	VBD
cord-345472-qrddwebe	256	17	reduced	reduce	VBN
cord-345472-qrddwebe	256	18	airway	airway	NN
cord-345472-qrddwebe	256	19	inflammation	inflammation	NN
cord-345472-qrddwebe	256	20	,	,	,
cord-345472-qrddwebe	256	21	characterised	characterise	VBN
cord-345472-qrddwebe	256	22	by	by	IN
cord-345472-qrddwebe	256	23	reduced	reduced	JJ
cord-345472-qrddwebe	256	24	eosinophils	eosinophil	NNS
cord-345472-qrddwebe	256	25	and	and	CC
cord-345472-qrddwebe	256	26	lymphocytes	lymphocyte	NNS
cord-345472-qrddwebe	256	27	recruited	recruit	VBN
cord-345472-qrddwebe	256	28	to	to	IN
cord-345472-qrddwebe	256	29	the	the	DT
cord-345472-qrddwebe	256	30	lung	lung	NN
cord-345472-qrddwebe	256	31	airways	airway	NNS
cord-345472-qrddwebe	256	32	during	during	IN
cord-345472-qrddwebe	256	33	experimental	experimental	JJ
cord-345472-qrddwebe	256	34	allergic	allergic	JJ
cord-345472-qrddwebe	256	35	asthma	asthma	NN
cord-345472-qrddwebe	256	36	[	[	-LRB-
cord-345472-qrddwebe	256	37	141	141	CD
cord-345472-qrddwebe	256	38	]	]	-RRB-
cord-345472-qrddwebe	256	39	.	.	.
cord-345472-qrddwebe	257	1	As	as	IN
cord-345472-qrddwebe	257	2	MMP-9	MMP-9	NNP
cord-345472-qrddwebe	257	3	levels	level	NNS
cord-345472-qrddwebe	257	4	are	be	VBP
cord-345472-qrddwebe	257	5	significantly	significantly	RB
cord-345472-qrddwebe	257	6	elevated	elevate	VBN
cord-345472-qrddwebe	257	7	in	in	IN
cord-345472-qrddwebe	257	8	RSV	RSV	NNP
cord-345472-qrddwebe	257	9	-	-	HYPH
cord-345472-qrddwebe	257	10	infected	infect	VBN
cord-345472-qrddwebe	257	11	children	child	NNS
cord-345472-qrddwebe	257	12	[	[	-LRB-
cord-345472-qrddwebe	257	13	133	133	CD
cord-345472-qrddwebe	257	14	]	]	-RRB-
cord-345472-qrddwebe	257	15	[	[	-LRB-
cord-345472-qrddwebe	257	16	134	134	CD
cord-345472-qrddwebe	257	17	]	]	-RRB-
cord-345472-qrddwebe	257	18	[	[	-LRB-
cord-345472-qrddwebe	257	19	135	135	CD
cord-345472-qrddwebe	257	20	]	]	-RRB-
cord-345472-qrddwebe	257	21	,	,	,
cord-345472-qrddwebe	257	22	selective	selective	JJ
cord-345472-qrddwebe	257	23	inhibition	inhibition	NN
cord-345472-qrddwebe	257	24	of	of	IN
cord-345472-qrddwebe	257	25	MMP-9	MMP-9	NNP
cord-345472-qrddwebe	257	26	activity	activity	NN
cord-345472-qrddwebe	257	27	may	may	MD
cord-345472-qrddwebe	257	28	be	be	VB
cord-345472-qrddwebe	257	29	of	of	IN
cord-345472-qrddwebe	257	30	significant	significant	JJ
cord-345472-qrddwebe	257	31	benefit	benefit	NN
cord-345472-qrddwebe	257	32	for	for	IN
cord-345472-qrddwebe	257	33	the	the	DT
cord-345472-qrddwebe	257	34	treatment	treatment	NN
cord-345472-qrddwebe	257	35	of	of	IN
cord-345472-qrddwebe	257	36	RSV	RSV	NNP
cord-345472-qrddwebe	257	37	bronchiolitis	bronchiolitis	NNP
cord-345472-qrddwebe	257	38	(	(	-LRB-
cord-345472-qrddwebe	257	39	Figure	figure	NN
cord-345472-qrddwebe	257	40	2	2	CD
cord-345472-qrddwebe	257	41	)	)	-RRB-
cord-345472-qrddwebe	257	42	.	.	.
cord-345472-qrddwebe	258	1	Inhibition	inhibition	NN
cord-345472-qrddwebe	258	2	of	of	IN
cord-345472-qrddwebe	258	3	NETosis	NETosis	NNP
cord-345472-qrddwebe	258	4	may	may	MD
cord-345472-qrddwebe	258	5	also	also	RB
cord-345472-qrddwebe	258	6	be	be	VB
cord-345472-qrddwebe	258	7	a	a	DT
cord-345472-qrddwebe	258	8	therapeutic	therapeutic	JJ
cord-345472-qrddwebe	258	9	option	option	NN
cord-345472-qrddwebe	258	10	.	.	.
cord-345472-qrddwebe	259	1	Strategies	strategy	NNS
cord-345472-qrddwebe	259	2	to	to	TO
cord-345472-qrddwebe	259	3	achieve	achieve	VB
cord-345472-qrddwebe	259	4	this	this	DT
cord-345472-qrddwebe	259	5	might	may	MD
cord-345472-qrddwebe	259	6	involve	involve	VB
cord-345472-qrddwebe	259	7	the	the	DT
cord-345472-qrddwebe	259	8	targeting	targeting	NN
cord-345472-qrddwebe	259	9	of	of	IN
cord-345472-qrddwebe	259	10	neutrophil	neutrophil	NN
cord-345472-qrddwebe	259	11	granules	granule	NNS
cord-345472-qrddwebe	259	12	(	(	-LRB-
cord-345472-qrddwebe	259	13	including	include	VBG
cord-345472-qrddwebe	259	14	elastases	elastase	NNS
cord-345472-qrddwebe	259	15	or	or	CC
cord-345472-qrddwebe	259	16	MPO	MPO	NNP
cord-345472-qrddwebe	259	17	)	)	-RRB-
cord-345472-qrddwebe	259	18	,	,	,
cord-345472-qrddwebe	259	19	neutrophil	neutrophil	NN
cord-345472-qrddwebe	259	20	-	-	HYPH
cord-345472-qrddwebe	259	21	activating	activate	VBG
cord-345472-qrddwebe	259	22	pattern	pattern	NN
cord-345472-qrddwebe	259	23	recognition	recognition	NN
cord-345472-qrddwebe	259	24	receptors	receptor	NNS
cord-345472-qrddwebe	259	25	(	(	-LRB-
cord-345472-qrddwebe	259	26	e.g.	e.g.	RB
cord-345472-qrddwebe	259	27	,	,	,
cord-345472-qrddwebe	259	28	TLRs	TLRs	NNP
cord-345472-qrddwebe	259	29	)	)	-RRB-
cord-345472-qrddwebe	259	30	or	or	CC
cord-345472-qrddwebe	259	31	enzymes	enzyme	NNS
cord-345472-qrddwebe	259	32	(	(	-LRB-
cord-345472-qrddwebe	259	33	NADPH	nadph	NN
cord-345472-qrddwebe	259	34	-	-	HYPH
cord-345472-qrddwebe	259	35	oxidase	oxidase	NN
cord-345472-qrddwebe	259	36	and	and	CC
cord-345472-qrddwebe	259	37	PAD4	PAD4	NNP
cord-345472-qrddwebe	259	38	)	)	-RRB-
cord-345472-qrddwebe	259	39	.	.	.
cord-345472-qrddwebe	260	1	The	the	DT
cord-345472-qrddwebe	260	2	NE	NE	NNP
cord-345472-qrddwebe	260	3	inhibitor	inhibitor	NN
cord-345472-qrddwebe	260	4	AZD9668	AZD9668	NNP
cord-345472-qrddwebe	260	5	improves	improve	VBZ
cord-345472-qrddwebe	260	6	lung	lung	NN
cord-345472-qrddwebe	260	7	function	function	NN
cord-345472-qrddwebe	260	8	in	in	IN
cord-345472-qrddwebe	260	9	patients	patient	NNS
cord-345472-qrddwebe	260	10	with	with	IN
cord-345472-qrddwebe	260	11	bronchiectasis	bronchiectasis	NN
cord-345472-qrddwebe	260	12	[	[	-LRB-
cord-345472-qrddwebe	260	13	142	142	CD
cord-345472-qrddwebe	260	14	]	]	-RRB-
cord-345472-qrddwebe	260	15	;	;	:
cord-345472-qrddwebe	260	16	however	however	RB
cord-345472-qrddwebe	260	17	,	,	,
cord-345472-qrddwebe	260	18	it	-PRON-	PRP
cord-345472-qrddwebe	260	19	is	be	VBZ
cord-345472-qrddwebe	260	20	yet	yet	RB
cord-345472-qrddwebe	260	21	to	to	TO
cord-345472-qrddwebe	260	22	be	be	VB
cord-345472-qrddwebe	260	23	tested	test	VBN
cord-345472-qrddwebe	260	24	for	for	IN
cord-345472-qrddwebe	260	25	efficacy	efficacy	NN
cord-345472-qrddwebe	260	26	in	in	IN
cord-345472-qrddwebe	260	27	infants	infant	NNS
cord-345472-qrddwebe	260	28	with	with	IN
cord-345472-qrddwebe	260	29	a	a	DT
cord-345472-qrddwebe	260	30	severe	severe	JJ
cord-345472-qrddwebe	260	31	RSV	RSV	NNP
cord-345472-qrddwebe	260	32	infection	infection	NN
cord-345472-qrddwebe	260	33	.	.	.
cord-345472-qrddwebe	261	1	Similarly	similarly	RB
cord-345472-qrddwebe	261	2	,	,	,
cord-345472-qrddwebe	261	3	selective	selective	JJ
cord-345472-qrddwebe	261	4	inhibition	inhibition	NN
cord-345472-qrddwebe	261	5	of	of	IN
cord-345472-qrddwebe	261	6	MPO	MPO	NNP
cord-345472-qrddwebe	261	7	with	with	IN
cord-345472-qrddwebe	261	8	PF-1355	PF-1355	NNP
cord-345472-qrddwebe	261	9	,	,	,
cord-345472-qrddwebe	261	10	which	which	WDT
cord-345472-qrddwebe	261	11	attenuates	attenuate	VBZ
cord-345472-qrddwebe	261	12	tissue	tissue	NN
cord-345472-qrddwebe	261	13	injury	injury	NN
cord-345472-qrddwebe	261	14	in	in	IN
cord-345472-qrddwebe	261	15	experimental	experimental	JJ
cord-345472-qrddwebe	261	16	immune	immune	JJ
cord-345472-qrddwebe	261	17	complex	complex	NN
cord-345472-qrddwebe	261	18	-	-	HYPH
cord-345472-qrddwebe	261	19	mediated	mediate	VBN
cord-345472-qrddwebe	261	20	alveolitis	alveolitis	NN
cord-345472-qrddwebe	261	21	[	[	-LRB-
cord-345472-qrddwebe	261	22	143	143	CD
cord-345472-qrddwebe	261	23	]	]	-RRB-
cord-345472-qrddwebe	261	24	,	,	,
cord-345472-qrddwebe	261	25	may	may	MD
cord-345472-qrddwebe	261	26	offer	offer	VB
cord-345472-qrddwebe	261	27	a	a	DT
cord-345472-qrddwebe	261	28	therapeutic	therapeutic	JJ
cord-345472-qrddwebe	261	29	benefit	benefit	NN
cord-345472-qrddwebe	261	30	against	against	IN
cord-345472-qrddwebe	261	31	severe	severe	JJ
cord-345472-qrddwebe	261	32	RSV	RSV	NNP
cord-345472-qrddwebe	261	33	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	261	34	(	(	-LRB-
cord-345472-qrddwebe	261	35	Figure	figure	NN
cord-345472-qrddwebe	261	36	2	2	CD
cord-345472-qrddwebe	261	37	)	)	-RRB-
cord-345472-qrddwebe	261	38	.	.	.
cord-345472-qrddwebe	262	1	The	the	DT
cord-345472-qrddwebe	262	2	detection	detection	NN
cord-345472-qrddwebe	262	3	of	of	IN
cord-345472-qrddwebe	262	4	pathogen	pathogen	NN
cord-345472-qrddwebe	262	5	-	-	HYPH
cord-345472-qrddwebe	262	6	associated	associate	VBN
cord-345472-qrddwebe	262	7	molecular	molecular	JJ
cord-345472-qrddwebe	262	8	patterns	pattern	NNS
cord-345472-qrddwebe	262	9	by	by	IN
cord-345472-qrddwebe	262	10	pattern	pattern	NN
cord-345472-qrddwebe	262	11	recognition	recognition	NN
cord-345472-qrddwebe	262	12	receptors	receptor	NNS
cord-345472-qrddwebe	262	13	on	on	IN
cord-345472-qrddwebe	262	14	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	262	15	can	can	MD
cord-345472-qrddwebe	262	16	induce	induce	VB
cord-345472-qrddwebe	262	17	NETosis	NETosis	NNP
cord-345472-qrddwebe	262	18	.	.	.
cord-345472-qrddwebe	263	1	Therefore	therefore	RB
cord-345472-qrddwebe	263	2	,	,	,
cord-345472-qrddwebe	263	3	pharmacological	pharmacological	JJ
cord-345472-qrddwebe	263	4	disruption	disruption	NN
cord-345472-qrddwebe	263	5	of	of	IN
cord-345472-qrddwebe	263	6	these	these	DT
cord-345472-qrddwebe	263	7	interactions	interaction	NNS
cord-345472-qrddwebe	263	8	may	may	MD
cord-345472-qrddwebe	263	9	attenuate	attenuate	VB
cord-345472-qrddwebe	263	10	NETosis	NETosis	NNP
cord-345472-qrddwebe	263	11	.	.	.
cord-345472-qrddwebe	264	1	For	for	IN
cord-345472-qrddwebe	264	2	instance	instance	NN
cord-345472-qrddwebe	264	3	,	,	,
cord-345472-qrddwebe	264	4	TAK-242	tak-242	DT
cord-345472-qrddwebe	264	5	,	,	,
cord-345472-qrddwebe	264	6	a	a	DT
cord-345472-qrddwebe	264	7	small	small	JJ
cord-345472-qrddwebe	264	8	molecule	molecule	NN
cord-345472-qrddwebe	264	9	TLR4	TLR4	NNP
cord-345472-qrddwebe	264	10	inhibitor	inhibitor	NN
cord-345472-qrddwebe	264	11	[	[	-LRB-
cord-345472-qrddwebe	264	12	144	144	CD
cord-345472-qrddwebe	264	13	]	]	-RRB-
cord-345472-qrddwebe	264	14	that	that	WDT
cord-345472-qrddwebe	264	15	reduces	reduce	VBZ
cord-345472-qrddwebe	264	16	inflammation	inflammation	NN
cord-345472-qrddwebe	264	17	,	,	,
cord-345472-qrddwebe	264	18	may	may	MD
cord-345472-qrddwebe	264	19	also	also	RB
cord-345472-qrddwebe	264	20	be	be	VB
cord-345472-qrddwebe	264	21	used	use	VBN
cord-345472-qrddwebe	264	22	to	to	TO
cord-345472-qrddwebe	264	23	regulate	regulate	VB
cord-345472-qrddwebe	264	24	NETosis	NETosis	NNP
cord-345472-qrddwebe	264	25	.	.	.
cord-345472-qrddwebe	265	1	Considering	consider	VBG
cord-345472-qrddwebe	265	2	that	that	IN
cord-345472-qrddwebe	265	3	the	the	DT
cord-345472-qrddwebe	265	4	formation	formation	NN
cord-345472-qrddwebe	265	5	of	of	IN
cord-345472-qrddwebe	265	6	NETs	nets	NN
cord-345472-qrddwebe	265	7	is	be	VBZ
cord-345472-qrddwebe	265	8	largely	largely	RB
cord-345472-qrddwebe	265	9	dependent	dependent	JJ
cord-345472-qrddwebe	265	10	on	on	IN
cord-345472-qrddwebe	265	11	the	the	DT
cord-345472-qrddwebe	265	12	activity	activity	NN
cord-345472-qrddwebe	265	13	of	of	IN
cord-345472-qrddwebe	265	14	NADPH	NADPH	NNP
cord-345472-qrddwebe	265	15	oxidase	oxidase	NN
cord-345472-qrddwebe	265	16	or	or	CC
cord-345472-qrddwebe	265	17	PAD4	PAD4	NNP
cord-345472-qrddwebe	265	18	,	,	,
cord-345472-qrddwebe	265	19	the	the	DT
cord-345472-qrddwebe	265	20	inhibition	inhibition	NN
cord-345472-qrddwebe	265	21	of	of	IN
cord-345472-qrddwebe	265	22	either	either	DT
cord-345472-qrddwebe	265	23	enzyme	enzyme	NN
cord-345472-qrddwebe	265	24	is	be	VBZ
cord-345472-qrddwebe	265	25	likely	likely	JJ
cord-345472-qrddwebe	265	26	to	to	TO
cord-345472-qrddwebe	265	27	decrease	decrease	VB
cord-345472-qrddwebe	265	28	the	the	DT
cord-345472-qrddwebe	265	29	magnitude	magnitude	NN
cord-345472-qrddwebe	265	30	of	of	IN
cord-345472-qrddwebe	265	31	neutrophil	neutrophil	NN
cord-345472-qrddwebe	265	32	-	-	HYPH
cord-345472-qrddwebe	265	33	associated	associate	VBN
cord-345472-qrddwebe	265	34	tissue	tissue	NN
cord-345472-qrddwebe	265	35	damage	damage	NN
cord-345472-qrddwebe	265	36	.	.	.
cord-345472-qrddwebe	266	1	Genetic	genetic	JJ
cord-345472-qrddwebe	266	2	deletion	deletion	NN
cord-345472-qrddwebe	266	3	of	of	IN
cord-345472-qrddwebe	266	4	PAD4	PAD4	NNP
cord-345472-qrddwebe	266	5	or	or	CC
cord-345472-qrddwebe	266	6	PAD4	PAD4	NNP
cord-345472-qrddwebe	266	7	inhibition	inhibition	NN
cord-345472-qrddwebe	266	8	by	by	IN
cord-345472-qrddwebe	266	9	Cl	Cl	NNP
cord-345472-qrddwebe	266	10	-	-	HYPH
cord-345472-qrddwebe	266	11	amidine	amidine	NNP
cord-345472-qrddwebe	266	12	or	or	CC
cord-345472-qrddwebe	266	13	BB	BB	NNP
cord-345472-qrddwebe	266	14	-	-	HYPH
cord-345472-qrddwebe	266	15	Cl	Cl	NNP
cord-345472-qrddwebe	266	16	-	-	HYPH
cord-345472-qrddwebe	266	17	amidine	amidine	NNP
cord-345472-qrddwebe	266	18	improves	improve	VBZ
cord-345472-qrddwebe	266	19	clinical	clinical	JJ
cord-345472-qrddwebe	266	20	outcomes	outcome	NNS
cord-345472-qrddwebe	266	21	in	in	IN
cord-345472-qrddwebe	266	22	several	several	JJ
cord-345472-qrddwebe	266	23	different	different	JJ
cord-345472-qrddwebe	266	24	mouse	mouse	NN
cord-345472-qrddwebe	266	25	models	model	NNS
cord-345472-qrddwebe	266	26	of	of	IN
cord-345472-qrddwebe	266	27	inflammatory	inflammatory	JJ
cord-345472-qrddwebe	266	28	disease	disease	NN
cord-345472-qrddwebe	266	29	[	[	-LRB-
cord-345472-qrddwebe	266	30	40	40	CD
cord-345472-qrddwebe	266	31	,	,	,
cord-345472-qrddwebe	266	32	145	145	CD
cord-345472-qrddwebe	266	33	,	,	,
cord-345472-qrddwebe	266	34	146	146	CD
cord-345472-qrddwebe	266	35	]	]	-RRB-
cord-345472-qrddwebe	266	36	,	,	,
cord-345472-qrddwebe	266	37	although	although	IN
cord-345472-qrddwebe	266	38	whether	whether	IN
cord-345472-qrddwebe	266	39	PAD4	PAD4	NNP
cord-345472-qrddwebe	266	40	inhibitors	inhibitor	NNS
cord-345472-qrddwebe	266	41	are	be	VBP
cord-345472-qrddwebe	266	42	beneficial	beneficial	JJ
cord-345472-qrddwebe	266	43	against	against	IN
cord-345472-qrddwebe	266	44	a	a	DT
cord-345472-qrddwebe	266	45	severe	severe	JJ
cord-345472-qrddwebe	266	46	RSV	RSV	NNP
cord-345472-qrddwebe	266	47	infection	infection	NN
cord-345472-qrddwebe	266	48	remains	remain	VBZ
cord-345472-qrddwebe	266	49	unknown	unknown	JJ
cord-345472-qrddwebe	266	50	.	.	.
cord-345472-qrddwebe	267	1	The	the	DT
cord-345472-qrddwebe	267	2	modulation	modulation	NN
cord-345472-qrddwebe	267	3	of	of	IN
cord-345472-qrddwebe	267	4	neutrophil	neutrophil	NN
cord-345472-qrddwebe	267	5	numbers	number	NNS
cord-345472-qrddwebe	267	6	or	or	CC
cord-345472-qrddwebe	267	7	function	function	NN
cord-345472-qrddwebe	267	8	is	be	VBZ
cord-345472-qrddwebe	267	9	evidently	evidently	RB
cord-345472-qrddwebe	267	10	a	a	DT
cord-345472-qrddwebe	267	11	promising	promising	JJ
cord-345472-qrddwebe	267	12	target	target	NN
cord-345472-qrddwebe	267	13	to	to	TO
cord-345472-qrddwebe	267	14	ameliorate	ameliorate	VB
cord-345472-qrddwebe	267	15	the	the	DT
cord-345472-qrddwebe	267	16	severity	severity	NN
cord-345472-qrddwebe	267	17	of	of	IN
cord-345472-qrddwebe	267	18	RSV	RSV	NNP
cord-345472-qrddwebe	267	19	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	267	20	.	.	.
cord-345472-qrddwebe	268	1	However	however	RB
cord-345472-qrddwebe	268	2	,	,	,
cord-345472-qrddwebe	268	3	several	several	JJ
cord-345472-qrddwebe	268	4	feasibility	feasibility	NN
cord-345472-qrddwebe	268	5	issues	issue	NNS
cord-345472-qrddwebe	268	6	remain	remain	VBP
cord-345472-qrddwebe	268	7	,	,	,
cord-345472-qrddwebe	268	8	particularly	particularly	RB
cord-345472-qrddwebe	268	9	in	in	IN
cord-345472-qrddwebe	268	10	relation	relation	NN
cord-345472-qrddwebe	268	11	to	to	IN
cord-345472-qrddwebe	268	12	safety	safety	NN
cord-345472-qrddwebe	268	13	and	and	CC
cord-345472-qrddwebe	268	14	specificity	specificity	NN
cord-345472-qrddwebe	268	15	.	.	.
cord-345472-qrddwebe	269	1	Selective	selective	JJ
cord-345472-qrddwebe	269	2	targeting	targeting	NN
cord-345472-qrddwebe	269	3	of	of	IN
cord-345472-qrddwebe	269	4	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	269	5	is	be	VBZ
cord-345472-qrddwebe	269	6	challenging	challenge	VBG
cord-345472-qrddwebe	269	7	due	due	IN
cord-345472-qrddwebe	269	8	to	to	IN
cord-345472-qrddwebe	269	9	their	-PRON-	PRP$
cord-345472-qrddwebe	269	10	close	close	JJ
cord-345472-qrddwebe	269	11	relationship	relationship	NN
cord-345472-qrddwebe	269	12	to	to	IN
cord-345472-qrddwebe	269	13	other	other	JJ
cord-345472-qrddwebe	269	14	myeloid	myeloid	JJ
cord-345472-qrddwebe	269	15	lineages	lineage	NNS
cord-345472-qrddwebe	269	16	,	,	,
cord-345472-qrddwebe	269	17	such	such	JJ
cord-345472-qrddwebe	269	18	as	as	IN
cord-345472-qrddwebe	269	19	monocytes	monocyte	NNS
cord-345472-qrddwebe	269	20	and	and	CC
cord-345472-qrddwebe	269	21	macrophages	macrophage	NNS
cord-345472-qrddwebe	269	22	.	.	.
cord-345472-qrddwebe	270	1	This	this	DT
cord-345472-qrddwebe	270	2	may	may	MD
cord-345472-qrddwebe	270	3	alter	alter	VB
cord-345472-qrddwebe	270	4	tissue	tissue	NN
cord-345472-qrddwebe	270	5	homeostasis	homeostasis	NN
cord-345472-qrddwebe	270	6	and	and	CC
cord-345472-qrddwebe	270	7	immune	immune	JJ
cord-345472-qrddwebe	270	8	defence	defence	NN
cord-345472-qrddwebe	270	9	against	against	IN
cord-345472-qrddwebe	270	10	other	other	JJ
cord-345472-qrddwebe	270	11	intracellular	intracellular	JJ
cord-345472-qrddwebe	270	12	pathogens	pathogen	NNS
cord-345472-qrddwebe	270	13	such	such	JJ
cord-345472-qrddwebe	270	14	as	as	IN
cord-345472-qrddwebe	270	15	Mycobacterium	Mycobacterium	NNP
cord-345472-qrddwebe	270	16	tuberculosis	tuberculosis	NN
cord-345472-qrddwebe	270	17	or	or	CC
cord-345472-qrddwebe	270	18	Listeria	Listeria	NNP
cord-345472-qrddwebe	270	19	monocytogenes	monocytogene	NNS
cord-345472-qrddwebe	270	20	.	.	.
cord-345472-qrddwebe	271	1	Moreover	moreover	RB
cord-345472-qrddwebe	271	2	,	,	,
cord-345472-qrddwebe	271	3	since	since	IN
cord-345472-qrddwebe	271	4	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	271	5	are	be	VBP
cord-345472-qrddwebe	271	6	important	important	JJ
cord-345472-qrddwebe	271	7	for	for	IN
cord-345472-qrddwebe	271	8	robust	robust	JJ
cord-345472-qrddwebe	271	9	antimicrobial	antimicrobial	JJ
cord-345472-qrddwebe	271	10	host	host	NN
cord-345472-qrddwebe	271	11	defence	defence	NN
cord-345472-qrddwebe	271	12	,	,	,
cord-345472-qrddwebe	271	13	their	-PRON-	PRP$
cord-345472-qrddwebe	271	14	therapeutic	therapeutic	JJ
cord-345472-qrddwebe	271	15	inhibition	inhibition	NN
cord-345472-qrddwebe	271	16	may	may	MD
cord-345472-qrddwebe	271	17	predispose	predispose	VB
cord-345472-qrddwebe	271	18	the	the	DT
cord-345472-qrddwebe	271	19	host	host	NN
cord-345472-qrddwebe	271	20	to	to	IN
cord-345472-qrddwebe	271	21	other	other	JJ
cord-345472-qrddwebe	271	22	infectious	infectious	JJ
cord-345472-qrddwebe	271	23	agents	agent	NNS
cord-345472-qrddwebe	271	24	or	or	CC
cord-345472-qrddwebe	271	25	effect	effect	VB
cord-345472-qrddwebe	271	26	colonisation	colonisation	NN
cord-345472-qrddwebe	271	27	by	by	IN
cord-345472-qrddwebe	271	28	commensals	commensal	NNS
cord-345472-qrddwebe	271	29	,	,	,
cord-345472-qrddwebe	271	30	which	which	WDT
cord-345472-qrddwebe	271	31	can	can	MD
cord-345472-qrddwebe	271	32	become	become	VB
cord-345472-qrddwebe	271	33	pathobionts	pathobiont	NNS
cord-345472-qrddwebe	271	34	if	if	IN
cord-345472-qrddwebe	271	35	left	leave	VBN
cord-345472-qrddwebe	271	36	unchecked	unchecked	JJ
cord-345472-qrddwebe	271	37	.	.	.
cord-345472-qrddwebe	272	1	To	to	TO
cord-345472-qrddwebe	272	2	overcome	overcome	VB
cord-345472-qrddwebe	272	3	this	this	DT
cord-345472-qrddwebe	272	4	,	,	,
cord-345472-qrddwebe	272	5	one	one	CD
cord-345472-qrddwebe	272	6	strategy	strategy	NN
cord-345472-qrddwebe	272	7	would	would	MD
cord-345472-qrddwebe	272	8	be	be	VB
cord-345472-qrddwebe	272	9	to	to	TO
cord-345472-qrddwebe	272	10	target	target	VB
cord-345472-qrddwebe	272	11	specific	specific	JJ
cord-345472-qrddwebe	272	12	neutrophil	neutrophil	NN
cord-345472-qrddwebe	272	13	subsets	subset	NNS
cord-345472-qrddwebe	272	14	,	,	,
cord-345472-qrddwebe	272	15	and	and	CC
cord-345472-qrddwebe	272	16	thus	thus	RB
cord-345472-qrddwebe	272	17	ablate	ablate	VB
cord-345472-qrddwebe	272	18	the	the	DT
cord-345472-qrddwebe	272	19	pathogenic	pathogenic	JJ
cord-345472-qrddwebe	272	20	population	population	NN
cord-345472-qrddwebe	272	21	without	without	IN
cord-345472-qrddwebe	272	22	compromising	compromise	VBG
cord-345472-qrddwebe	272	23	the	the	DT
cord-345472-qrddwebe	272	24	beneficial	beneficial	JJ
cord-345472-qrddwebe	272	25	effect	effect	NN
cord-345472-qrddwebe	272	26	of	of	IN
cord-345472-qrddwebe	272	27	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	272	28	in	in	IN
cord-345472-qrddwebe	272	29	mediating	mediate	VBG
cord-345472-qrddwebe	272	30	antimicrobial	antimicrobial	JJ
cord-345472-qrddwebe	272	31	host	host	NN
cord-345472-qrddwebe	272	32	defence	defence	NN
cord-345472-qrddwebe	272	33	.	.	.
cord-345472-qrddwebe	273	1	New	new	JJ
cord-345472-qrddwebe	273	2	insights	insight	NNS
cord-345472-qrddwebe	273	3	are	be	VBP
cord-345472-qrddwebe	273	4	needed	need	VBN
cord-345472-qrddwebe	273	5	to	to	TO
cord-345472-qrddwebe	273	6	identify	identify	VB
cord-345472-qrddwebe	273	7	approaches	approach	NNS
cord-345472-qrddwebe	273	8	that	that	WDT
cord-345472-qrddwebe	273	9	can	can	MD
cord-345472-qrddwebe	273	10	support	support	VB
cord-345472-qrddwebe	273	11	this	this	DT
cord-345472-qrddwebe	273	12	possibility	possibility	NN
cord-345472-qrddwebe	273	13	.	.	.
cord-345472-qrddwebe	274	1	Most	Most	JJS
cord-345472-qrddwebe	274	2	therapeutic	therapeutic	JJ
cord-345472-qrddwebe	274	3	approaches	approach	NNS
cord-345472-qrddwebe	274	4	in	in	IN
cord-345472-qrddwebe	274	5	the	the	DT
cord-345472-qrddwebe	274	6	pipeline	pipeline	NN
cord-345472-qrddwebe	274	7	have	have	VBP
cord-345472-qrddwebe	274	8	focused	focus	VBN
cord-345472-qrddwebe	274	9	on	on	IN
cord-345472-qrddwebe	274	10	inhibiting	inhibit	VBG
cord-345472-qrddwebe	274	11	excessive	excessive	JJ
cord-345472-qrddwebe	274	12	neutrophil	neutrophil	NN
cord-345472-qrddwebe	274	13	function	function	NN
cord-345472-qrddwebe	274	14	in	in	IN
cord-345472-qrddwebe	274	15	treating	treat	VBG
cord-345472-qrddwebe	274	16	disease	disease	NN
cord-345472-qrddwebe	274	17	pathology	pathology	NN
cord-345472-qrddwebe	274	18	.	.	.
cord-345472-qrddwebe	275	1	However	however	RB
cord-345472-qrddwebe	275	2	,	,	,
cord-345472-qrddwebe	275	3	an	an	DT
cord-345472-qrddwebe	275	4	alternative	alternative	JJ
cord-345472-qrddwebe	275	5	approach	approach	NN
cord-345472-qrddwebe	275	6	is	be	VBZ
cord-345472-qrddwebe	275	7	to	to	TO
cord-345472-qrddwebe	275	8	modify	modify	VB
cord-345472-qrddwebe	275	9	neutrophil	neutrophil	NN
cord-345472-qrddwebe	275	10	function	function	NN
cord-345472-qrddwebe	275	11	to	to	TO
cord-345472-qrddwebe	275	12	boost	boost	VB
cord-345472-qrddwebe	275	13	host	host	NN
cord-345472-qrddwebe	275	14	immunity	immunity	NN
cord-345472-qrddwebe	275	15	against	against	IN
cord-345472-qrddwebe	275	16	pathogenic	pathogenic	JJ
cord-345472-qrddwebe	275	17	microbes	microbe	NNS
cord-345472-qrddwebe	275	18	,	,	,
cord-345472-qrddwebe	275	19	particularly	particularly	RB
cord-345472-qrddwebe	275	20	in	in	IN
cord-345472-qrddwebe	275	21	the	the	DT
cord-345472-qrddwebe	275	22	elderly	elderly	JJ
cord-345472-qrddwebe	275	23	.	.	.
cord-345472-qrddwebe	276	1	For	for	IN
cord-345472-qrddwebe	276	2	instance	instance	NN
cord-345472-qrddwebe	276	3	,	,	,
cord-345472-qrddwebe	276	4	the	the	DT
cord-345472-qrddwebe	276	5	cholesterol	cholesterol	NN
cord-345472-qrddwebe	276	6	-	-	HYPH
cord-345472-qrddwebe	276	7	lowering	lower	VBG
cord-345472-qrddwebe	276	8	medication	medication	NN
cord-345472-qrddwebe	276	9	simvastatin	simvastatin	NN
cord-345472-qrddwebe	276	10	has	have	VBZ
cord-345472-qrddwebe	276	11	been	be	VBN
cord-345472-qrddwebe	276	12	associated	associate	VBN
cord-345472-qrddwebe	276	13	with	with	IN
cord-345472-qrddwebe	276	14	improved	improved	JJ
cord-345472-qrddwebe	276	15	neutrophil	neutrophil	NN
cord-345472-qrddwebe	276	16	function	function	NN
cord-345472-qrddwebe	276	17	and	and	CC
cord-345472-qrddwebe	276	18	immunity	immunity	NN
cord-345472-qrddwebe	276	19	against	against	IN
cord-345472-qrddwebe	276	20	bacterial	bacterial	JJ
cord-345472-qrddwebe	276	21	infection	infection	NN
cord-345472-qrddwebe	276	22	in	in	IN
cord-345472-qrddwebe	276	23	humans	human	NNS
cord-345472-qrddwebe	276	24	[	[	-LRB-
cord-345472-qrddwebe	276	25	147	147	CD
cord-345472-qrddwebe	276	26	]	]	-RRB-
cord-345472-qrddwebe	276	27	.	.	.
cord-345472-qrddwebe	277	1	In	in	IN
cord-345472-qrddwebe	277	2	this	this	DT
cord-345472-qrddwebe	277	3	study	study	NN
cord-345472-qrddwebe	277	4	,	,	,
cord-345472-qrddwebe	277	5	adding	add	VBG
cord-345472-qrddwebe	277	6	simvastatin	simvastatin	NN
cord-345472-qrddwebe	277	7	to	to	IN
cord-345472-qrddwebe	277	8	the	the	DT
cord-345472-qrddwebe	277	9	normal	normal	JJ
cord-345472-qrddwebe	277	10	treatment	treatment	NN
cord-345472-qrddwebe	277	11	regimen	regimen	NN
cord-345472-qrddwebe	277	12	significantly	significantly	RB
cord-345472-qrddwebe	277	13	reduced	reduce	VBD
cord-345472-qrddwebe	277	14	the	the	DT
cord-345472-qrddwebe	277	15	severity	severity	NN
cord-345472-qrddwebe	277	16	of	of	IN
cord-345472-qrddwebe	277	17	bacterial	bacterial	JJ
cord-345472-qrddwebe	277	18	pneumonia	pneumonia	NN
cord-345472-qrddwebe	277	19	and	and	CC
cord-345472-qrddwebe	277	20	sepsis	sepsis	NN
cord-345472-qrddwebe	277	21	in	in	IN
cord-345472-qrddwebe	277	22	patients	patient	NNS
cord-345472-qrddwebe	277	23	older	old	JJR
cord-345472-qrddwebe	277	24	than	than	IN
cord-345472-qrddwebe	277	25	62	62	CD
cord-345472-qrddwebe	277	26	years	year	NNS
cord-345472-qrddwebe	277	27	[	[	-LRB-
cord-345472-qrddwebe	277	28	147	147	CD
cord-345472-qrddwebe	277	29	]	]	-RRB-
cord-345472-qrddwebe	277	30	.	.	.
cord-345472-qrddwebe	278	1	Mechanistically	Mechanistically	NNP
cord-345472-qrddwebe	278	2	,	,	,
cord-345472-qrddwebe	278	3	simvastatin	simvastatin	NN
cord-345472-qrddwebe	278	4	acted	act	VBN
cord-345472-qrddwebe	278	5	by	by	IN
cord-345472-qrddwebe	278	6	augmenting	augment	VBG
cord-345472-qrddwebe	278	7	the	the	DT
cord-345472-qrddwebe	278	8	migratory	migratory	JJ
cord-345472-qrddwebe	278	9	accuracy	accuracy	NN
cord-345472-qrddwebe	278	10	of	of	IN
cord-345472-qrddwebe	278	11	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	278	12	into	into	IN
cord-345472-qrddwebe	278	13	tissues	tissue	NNS
cord-345472-qrddwebe	278	14	,	,	,
cord-345472-qrddwebe	278	15	albeit	albeit	IN
cord-345472-qrddwebe	278	16	with	with	IN
cord-345472-qrddwebe	278	17	reduced	reduce	VBN
cord-345472-qrddwebe	278	18	NETosis	netosis	NN
cord-345472-qrddwebe	278	19	and	and	CC
cord-345472-qrddwebe	278	20	NE	NE	NNP
cord-345472-qrddwebe	278	21	release	release	NN
cord-345472-qrddwebe	278	22	,	,	,
cord-345472-qrddwebe	278	23	which	which	WDT
cord-345472-qrddwebe	278	24	promoted	promote	VBD
cord-345472-qrddwebe	278	25	optimal	optimal	JJ
cord-345472-qrddwebe	278	26	non	non	JJ
cord-345472-qrddwebe	278	27	-	-	JJ
cord-345472-qrddwebe	278	28	inflammatory	inflammatory	JJ
cord-345472-qrddwebe	278	29	bacterial	bacterial	JJ
cord-345472-qrddwebe	278	30	control	control	NN
cord-345472-qrddwebe	278	31	.	.	.
cord-345472-qrddwebe	279	1	Therefore	therefore	RB
cord-345472-qrddwebe	279	2	,	,	,
cord-345472-qrddwebe	279	3	pharmacological	pharmacological	JJ
cord-345472-qrddwebe	279	4	approaches	approach	NNS
cord-345472-qrddwebe	279	5	to	to	TO
cord-345472-qrddwebe	279	6	rejuvenate	rejuvenate	VB
cord-345472-qrddwebe	279	7	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	279	8	in	in	IN
cord-345472-qrddwebe	279	9	the	the	DT
cord-345472-qrddwebe	279	10	elderly	elderly	JJ
cord-345472-qrddwebe	279	11	might	may	MD
cord-345472-qrddwebe	279	12	be	be	VB
cord-345472-qrddwebe	279	13	beneficial	beneficial	JJ
cord-345472-qrddwebe	279	14	in	in	IN
cord-345472-qrddwebe	279	15	boosting	boost	VBG
cord-345472-qrddwebe	279	16	immunity	immunity	NN
cord-345472-qrddwebe	279	17	against	against	IN
cord-345472-qrddwebe	279	18	RSV	RSV	NNP
cord-345472-qrddwebe	279	19	.	.	.
cord-345472-qrddwebe	280	1	There	there	EX
cord-345472-qrddwebe	280	2	remains	remain	VBZ
cord-345472-qrddwebe	280	3	a	a	DT
cord-345472-qrddwebe	280	4	pressing	press	VBG
cord-345472-qrddwebe	280	5	need	need	NN
cord-345472-qrddwebe	280	6	to	to	TO
cord-345472-qrddwebe	280	7	develop	develop	VB
cord-345472-qrddwebe	280	8	new	new	JJ
cord-345472-qrddwebe	280	9	treatments	treatment	NNS
cord-345472-qrddwebe	280	10	to	to	TO
cord-345472-qrddwebe	280	11	reduce	reduce	VB
cord-345472-qrddwebe	280	12	the	the	DT
cord-345472-qrddwebe	280	13	significant	significant	JJ
cord-345472-qrddwebe	280	14	morbidity	morbidity	NN
cord-345472-qrddwebe	280	15	and	and	CC
cord-345472-qrddwebe	280	16	mortality	mortality	NN
cord-345472-qrddwebe	280	17	associated	associate	VBN
cord-345472-qrddwebe	280	18	with	with	IN
cord-345472-qrddwebe	280	19	severe	severe	JJ
cord-345472-qrddwebe	280	20	RSV	RSV	NNP
cord-345472-qrddwebe	280	21	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	280	22	.	.	.
cord-345472-qrddwebe	281	1	Neutrophils	neutrophil	NNS
cord-345472-qrddwebe	281	2	contribute	contribute	VBP
cord-345472-qrddwebe	281	3	to	to	TO
cord-345472-qrddwebe	281	4	host	host	NN
cord-345472-qrddwebe	281	5	immunity	immunity	NN
cord-345472-qrddwebe	281	6	against	against	IN
cord-345472-qrddwebe	281	7	RSV	RSV	NNP
cord-345472-qrddwebe	281	8	;	;	:
cord-345472-qrddwebe	281	9	however	however	RB
cord-345472-qrddwebe	281	10	,	,	,
cord-345472-qrddwebe	281	11	they	-PRON-	PRP
cord-345472-qrddwebe	281	12	are	be	VBP
cord-345472-qrddwebe	281	13	strongly	strongly	RB
cord-345472-qrddwebe	281	14	associated	associate	VBN
cord-345472-qrddwebe	281	15	with	with	IN
cord-345472-qrddwebe	281	16	the	the	DT
cord-345472-qrddwebe	281	17	development	development	NN
cord-345472-qrddwebe	281	18	of	of	IN
cord-345472-qrddwebe	281	19	severe	severe	JJ
cord-345472-qrddwebe	281	20	disease	disease	NN
cord-345472-qrddwebe	281	21	and	and	CC
cord-345472-qrddwebe	281	22	are	be	VBP
cord-345472-qrddwebe	281	23	thus	thus	RB
cord-345472-qrddwebe	281	24	a	a	DT
cord-345472-qrddwebe	281	25	logical	logical	JJ
cord-345472-qrddwebe	281	26	target	target	NN
cord-345472-qrddwebe	281	27	for	for	IN
cord-345472-qrddwebe	281	28	therapeutic	therapeutic	JJ
cord-345472-qrddwebe	281	29	intervention	intervention	NN
cord-345472-qrddwebe	281	30	.	.	.
cord-345472-qrddwebe	282	1	New	new	JJ
cord-345472-qrddwebe	282	2	technological	technological	JJ
cord-345472-qrddwebe	282	3	approaches	approach	NNS
cord-345472-qrddwebe	282	4	,	,	,
cord-345472-qrddwebe	282	5	such	such	JJ
cord-345472-qrddwebe	282	6	as	as	IN
cord-345472-qrddwebe	282	7	single	single	JJ
cord-345472-qrddwebe	282	8	cell	cell	NN
cord-345472-qrddwebe	282	9	RNA	rna	NN
cord-345472-qrddwebe	282	10	sequencing	sequencing	NN
cord-345472-qrddwebe	282	11	,	,	,
cord-345472-qrddwebe	282	12	combined	combine	VBN
cord-345472-qrddwebe	282	13	with	with	IN
cord-345472-qrddwebe	282	14	proteomics	proteomic	NNS
cord-345472-qrddwebe	282	15	,	,	,
cord-345472-qrddwebe	282	16	metabolomics	metabolomic	NNS
cord-345472-qrddwebe	282	17	,	,	,
cord-345472-qrddwebe	282	18	and	and	CC
cord-345472-qrddwebe	282	19	advances	advance	VBZ
cord-345472-qrddwebe	282	20	in	in	IN
cord-345472-qrddwebe	282	21	flow	flow	NN
cord-345472-qrddwebe	282	22	cytometry	cytometry	NN
cord-345472-qrddwebe	282	23	that	that	WDT
cord-345472-qrddwebe	282	24	allow	allow	VBP
cord-345472-qrddwebe	282	25	for	for	IN
cord-345472-qrddwebe	282	26	multi	multi	JJ
cord-345472-qrddwebe	282	27	-	-	JJ
cord-345472-qrddwebe	282	28	parameter	parameter	NN
cord-345472-qrddwebe	282	29	analyses	analysis	NNS
cord-345472-qrddwebe	282	30	,	,	,
cord-345472-qrddwebe	282	31	must	must	MD
cord-345472-qrddwebe	282	32	now	now	RB
cord-345472-qrddwebe	282	33	be	be	VB
cord-345472-qrddwebe	282	34	applied	apply	VBN
cord-345472-qrddwebe	282	35	to	to	IN
cord-345472-qrddwebe	282	36	clinical	clinical	JJ
cord-345472-qrddwebe	282	37	samples	sample	NNS
cord-345472-qrddwebe	282	38	from	from	IN
cord-345472-qrddwebe	282	39	infants	infant	NNS
cord-345472-qrddwebe	282	40	with	with	IN
cord-345472-qrddwebe	282	41	mild	mild	JJ
cord-345472-qrddwebe	282	42	and	and	CC
cord-345472-qrddwebe	282	43	severe	severe	JJ
cord-345472-qrddwebe	282	44	disease	disease	NN
cord-345472-qrddwebe	282	45	to	to	TO
cord-345472-qrddwebe	282	46	gain	gain	VB
cord-345472-qrddwebe	282	47	a	a	DT
cord-345472-qrddwebe	282	48	greater	great	JJR
cord-345472-qrddwebe	282	49	understanding	understanding	NN
cord-345472-qrddwebe	282	50	of	of	IN
cord-345472-qrddwebe	282	51	the	the	DT
cord-345472-qrddwebe	282	52	full	full	JJ
cord-345472-qrddwebe	282	53	repertoire	repertoire	NN
cord-345472-qrddwebe	282	54	of	of	IN
cord-345472-qrddwebe	282	55	neutrophil	neutrophil	NN
cord-345472-qrddwebe	282	56	heterogeneity	heterogeneity	NN
cord-345472-qrddwebe	282	57	and	and	CC
cord-345472-qrddwebe	282	58	function	function	VB
cord-345472-qrddwebe	282	59	in	in	IN
cord-345472-qrddwebe	282	60	the	the	DT
cord-345472-qrddwebe	282	61	pathogenesis	pathogenesis	NN
cord-345472-qrddwebe	282	62	of	of	IN
cord-345472-qrddwebe	282	63	RSV	RSV	NNP
cord-345472-qrddwebe	282	64	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	282	65	.	.	.
cord-345472-qrddwebe	283	1	Such	such	JJ
cord-345472-qrddwebe	283	2	information	information	NN
cord-345472-qrddwebe	283	3	will	will	MD
cord-345472-qrddwebe	283	4	reveal	reveal	VB
cord-345472-qrddwebe	283	5	important	important	JJ
cord-345472-qrddwebe	283	6	insights	insight	NNS
cord-345472-qrddwebe	283	7	into	into	IN
cord-345472-qrddwebe	283	8	neutrophil	neutrophil	NN
cord-345472-qrddwebe	283	9	diversity	diversity	NN
cord-345472-qrddwebe	283	10	and	and	CC
cord-345472-qrddwebe	283	11	identify	identify	VB
cord-345472-qrddwebe	283	12	novel	novel	NN
cord-345472-qrddwebe	283	13	tractable	tractable	JJ
cord-345472-qrddwebe	283	14	and	and	CC
cord-345472-qrddwebe	283	15	druggable	druggable	JJ
cord-345472-qrddwebe	283	16	targets	target	NNS
cord-345472-qrddwebe	283	17	to	to	TO
cord-345472-qrddwebe	283	18	ameliorate	ameliorate	VB
cord-345472-qrddwebe	283	19	the	the	DT
cord-345472-qrddwebe	283	20	severity	severity	NN
cord-345472-qrddwebe	283	21	of	of	IN
cord-345472-qrddwebe	283	22	RSV	RSV	NNP
cord-345472-qrddwebe	283	23	-	-	HYPH
cord-345472-qrddwebe	283	24	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	283	25	.	.	.
cord-345472-qrddwebe	283	26	 	 	_SP
cord-345472-qrddwebe	284	1	Viral	viral	JJ
cord-345472-qrddwebe	284	2	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	284	3	Global	Global	NNP
cord-345472-qrddwebe	284	4	,	,	,
cord-345472-qrddwebe	284	5	regional	regional	JJ
cord-345472-qrddwebe	284	6	,	,	,
cord-345472-qrddwebe	284	7	and	and	CC
cord-345472-qrddwebe	284	8	national	national	JJ
cord-345472-qrddwebe	284	9	disease	disease	NN
cord-345472-qrddwebe	284	10	burden	burden	NN
cord-345472-qrddwebe	284	11	estimates	estimate	NNS
cord-345472-qrddwebe	284	12	of	of	IN
cord-345472-qrddwebe	284	13	acute	acute	JJ
cord-345472-qrddwebe	284	14	lower	low	JJR
cord-345472-qrddwebe	284	15	respiratory	respiratory	JJ
cord-345472-qrddwebe	284	16	infections	infection	NNS
cord-345472-qrddwebe	284	17	due	due	JJ
cord-345472-qrddwebe	284	18	to	to	IN
cord-345472-qrddwebe	284	19	respiratory	respiratory	JJ
cord-345472-qrddwebe	284	20	syncytial	syncytial	JJ
cord-345472-qrddwebe	284	21	virus	virus	NN
cord-345472-qrddwebe	284	22	in	in	IN
cord-345472-qrddwebe	284	23	young	young	JJ
cord-345472-qrddwebe	284	24	children	child	NNS
cord-345472-qrddwebe	284	25	in	in	IN
cord-345472-qrddwebe	284	26	2015	2015	CD
cord-345472-qrddwebe	285	1	:	:	:
cord-345472-qrddwebe	285	2	A	a	DT
cord-345472-qrddwebe	285	3	systematic	systematic	JJ
cord-345472-qrddwebe	285	4	review	review	NN
cord-345472-qrddwebe	285	5	and	and	CC
cord-345472-qrddwebe	285	6	modelling	modelling	NN
cord-345472-qrddwebe	285	7	study	study	NN
cord-345472-qrddwebe	285	8	Respiratory	respiratory	JJ
cord-345472-qrddwebe	285	9	syncytial	syncytial	JJ
cord-345472-qrddwebe	285	10	virus	virus	NN
cord-345472-qrddwebe	285	11	and	and	CC
cord-345472-qrddwebe	285	12	parainfluenza	parainfluenza	NN
cord-345472-qrddwebe	285	13	virus	virus	NN
cord-345472-qrddwebe	285	14	Respiratory	respiratory	JJ
cord-345472-qrddwebe	285	15	syncytial	syncytial	JJ
cord-345472-qrddwebe	285	16	virus	virus	NN
cord-345472-qrddwebe	285	17	vaccine	vaccine	NN
cord-345472-qrddwebe	285	18	development	development	NN
cord-345472-qrddwebe	285	19	Novel	Novel	NNP
cord-345472-qrddwebe	285	20	antigens	antigen	NNS
cord-345472-qrddwebe	285	21	for	for	IN
cord-345472-qrddwebe	285	22	RSV	RSV	NNP
cord-345472-qrddwebe	285	23	vaccines	vaccine	NNS
cord-345472-qrddwebe	285	24	Role	role	NN
cord-345472-qrddwebe	285	25	of	of	IN
cord-345472-qrddwebe	285	26	viral	viral	JJ
cord-345472-qrddwebe	285	27	infections	infection	NNS
cord-345472-qrddwebe	285	28	in	in	IN
cord-345472-qrddwebe	285	29	the	the	DT
cord-345472-qrddwebe	285	30	development	development	NN
cord-345472-qrddwebe	285	31	and	and	CC
cord-345472-qrddwebe	285	32	exacerbation	exacerbation	NN
cord-345472-qrddwebe	285	33	of	of	IN
cord-345472-qrddwebe	285	34	asthma	asthma	NN
cord-345472-qrddwebe	285	35	in	in	IN
cord-345472-qrddwebe	285	36	children	child	NNS
cord-345472-qrddwebe	285	37	Respiratory	respiratory	JJ
cord-345472-qrddwebe	285	38	syncytial	syncytial	JJ
cord-345472-qrddwebe	285	39	virus	virus	NN
cord-345472-qrddwebe	285	40	binds	bind	VBZ
cord-345472-qrddwebe	285	41	and	and	CC
cord-345472-qrddwebe	285	42	undergoes	undergo	VBZ
cord-345472-qrddwebe	285	43	transcription	transcription	NN
cord-345472-qrddwebe	285	44	in	in	IN
cord-345472-qrddwebe	285	45	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	285	46	from	from	IN
cord-345472-qrddwebe	285	47	the	the	DT
cord-345472-qrddwebe	285	48	blood	blood	NN
cord-345472-qrddwebe	285	49	and	and	CC
cord-345472-qrddwebe	285	50	airways	airway	NNS
cord-345472-qrddwebe	285	51	of	of	IN
cord-345472-qrddwebe	285	52	infants	infant	NNS
cord-345472-qrddwebe	285	53	with	with	IN
cord-345472-qrddwebe	285	54	severe	severe	JJ
cord-345472-qrddwebe	285	55	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	285	56	Bronchoalveolar	Bronchoalveolar	NNP
cord-345472-qrddwebe	285	57	lavage	lavage	NN
cord-345472-qrddwebe	285	58	cellularity	cellularity	NN
cord-345472-qrddwebe	285	59	in	in	IN
cord-345472-qrddwebe	285	60	infants	infant	NNS
cord-345472-qrddwebe	285	61	with	with	IN
cord-345472-qrddwebe	285	62	severe	severe	JJ
cord-345472-qrddwebe	285	63	respiratory	respiratory	JJ
cord-345472-qrddwebe	285	64	syncytial	syncytial	JJ
cord-345472-qrddwebe	285	65	virus	virus	NN
cord-345472-qrddwebe	285	66	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	286	1	The	the	DT
cord-345472-qrddwebe	286	2	histopathology	histopathology	NN
cord-345472-qrddwebe	286	3	of	of	IN
cord-345472-qrddwebe	286	4	fatal	fatal	JJ
cord-345472-qrddwebe	286	5	untreated	untreated	JJ
cord-345472-qrddwebe	286	6	human	human	JJ
cord-345472-qrddwebe	286	7	respiratory	respiratory	JJ
cord-345472-qrddwebe	286	8	syncytial	syncytial	JJ
cord-345472-qrddwebe	286	9	virus	virus	NN
cord-345472-qrddwebe	286	10	infection	infection	NN
cord-345472-qrddwebe	286	11	Neutrophil	Neutrophil	NNP
cord-345472-qrddwebe	286	12	kinetics	kinetic	NNS
cord-345472-qrddwebe	286	13	in	in	IN
cord-345472-qrddwebe	286	14	man	man	NN
cord-345472-qrddwebe	286	15	Heterogeneity	heterogeneity	NN
cord-345472-qrddwebe	286	16	of	of	IN
cord-345472-qrddwebe	286	17	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	286	18	Neutrophils	neutrophil	NNS
cord-345472-qrddwebe	286	19	:	:	:
cord-345472-qrddwebe	287	1	Between	between	IN
cord-345472-qrddwebe	287	2	host	host	NN
cord-345472-qrddwebe	287	3	defence	defence	NN
cord-345472-qrddwebe	287	4	,	,	,
cord-345472-qrddwebe	287	5	immune	immune	JJ
cord-345472-qrddwebe	287	6	modulation	modulation	NN
cord-345472-qrddwebe	287	7	,	,	,
cord-345472-qrddwebe	287	8	and	and	CC
cord-345472-qrddwebe	287	9	tissue	tissue	NN
cord-345472-qrddwebe	287	10	injury	injury	NN
cord-345472-qrddwebe	288	1	Neutrophil	Neutrophil	NNP
cord-345472-qrddwebe	288	2	diversity	diversity	NN
cord-345472-qrddwebe	288	3	in	in	IN
cord-345472-qrddwebe	288	4	health	health	NN
cord-345472-qrddwebe	288	5	and	and	CC
cord-345472-qrddwebe	288	6	disease	disease	NN
cord-345472-qrddwebe	288	7	Phagocytosis	Phagocytosis	NNP
cord-345472-qrddwebe	288	8	by	by	IN
cord-345472-qrddwebe	288	9	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	288	10	Cell	cell	NN
cord-345472-qrddwebe	288	11	intrinsic	intrinsic	JJ
cord-345472-qrddwebe	288	12	functions	function	NNS
cord-345472-qrddwebe	288	13	of	of	IN
cord-345472-qrddwebe	288	14	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	288	15	and	and	CC
cord-345472-qrddwebe	288	16	their	-PRON-	PRP$
cord-345472-qrddwebe	288	17	manipulation	manipulation	NN
cord-345472-qrddwebe	288	18	by	by	IN
cord-345472-qrddwebe	288	19	pathogens	pathogen	NNS
cord-345472-qrddwebe	288	20	Biological	biological	JJ
cord-345472-qrddwebe	288	21	roles	role	NNS
cord-345472-qrddwebe	288	22	of	of	IN
cord-345472-qrddwebe	288	23	neutrophil	neutrophil	NN
cord-345472-qrddwebe	288	24	-	-	HYPH
cord-345472-qrddwebe	288	25	derived	derive	VBN
cord-345472-qrddwebe	288	26	granule	granule	NN
cord-345472-qrddwebe	288	27	proteins	protein	NNS
cord-345472-qrddwebe	288	28	and	and	CC
cord-345472-qrddwebe	288	29	cytokines	cytokine	NNS
cord-345472-qrddwebe	288	30	Neutrophil	Neutrophil	NNP
cord-345472-qrddwebe	288	31	degranulation	degranulation	NN
cord-345472-qrddwebe	288	32	,	,	,
cord-345472-qrddwebe	288	33	plasticity	plasticity	NN
cord-345472-qrddwebe	288	34	,	,	,
cord-345472-qrddwebe	288	35	and	and	CC
cord-345472-qrddwebe	288	36	cancer	cancer	NN
cord-345472-qrddwebe	288	37	metastasis	metastasis	NN
cord-345472-qrddwebe	288	38	Neutrophils	Neutrophils	NNP
cord-345472-qrddwebe	288	39	in	in	IN
cord-345472-qrddwebe	288	40	the	the	DT
cord-345472-qrddwebe	288	41	activation	activation	NN
cord-345472-qrddwebe	288	42	and	and	CC
cord-345472-qrddwebe	288	43	regulation	regulation	NN
cord-345472-qrddwebe	288	44	of	of	IN
cord-345472-qrddwebe	288	45	innate	innate	JJ
cord-345472-qrddwebe	288	46	and	and	CC
cord-345472-qrddwebe	288	47	adaptive	adaptive	JJ
cord-345472-qrddwebe	288	48	immunity	immunity	NN
cord-345472-qrddwebe	288	49	Neutrophils	Neutrophils	NNP
cord-345472-qrddwebe	288	50	in	in	IN
cord-345472-qrddwebe	288	51	cancer	cancer	NN
cord-345472-qrddwebe	288	52	:	:	:
cord-345472-qrddwebe	289	1	Neutral	neutral	JJ
cord-345472-qrddwebe	289	2	no	no	DT
cord-345472-qrddwebe	289	3	more	more	JJR
cord-345472-qrddwebe	289	4	Neutrophil	Neutrophil	NNP
cord-345472-qrddwebe	289	5	-	-	HYPH
cord-345472-qrddwebe	289	6	derived	derive	VBN
cord-345472-qrddwebe	289	7	cathelicidin	cathelicidin	NN
cord-345472-qrddwebe	289	8	protects	protect	VBZ
cord-345472-qrddwebe	289	9	from	from	IN
cord-345472-qrddwebe	289	10	neointimal	neointimal	JJ
cord-345472-qrddwebe	289	11	hyperplasia	hyperplasia	NNP
cord-345472-qrddwebe	290	1	The	the	DT
cord-345472-qrddwebe	290	2	role	role	NN
cord-345472-qrddwebe	290	3	of	of	IN
cord-345472-qrddwebe	290	4	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	290	5	in	in	IN
cord-345472-qrddwebe	290	6	inflammation	inflammation	NN
cord-345472-qrddwebe	290	7	resolution	resolution	NN
cord-345472-qrddwebe	290	8	Mice	mouse	NNS
cord-345472-qrddwebe	290	9	lacking	lack	VBG
cord-345472-qrddwebe	291	1	neutrophil	neutrophil	NN
cord-345472-qrddwebe	291	2	elastase	elastase	NN
cord-345472-qrddwebe	291	3	reveal	reveal	VBP
cord-345472-qrddwebe	291	4	impaired	impaired	JJ
cord-345472-qrddwebe	291	5	host	host	NN
cord-345472-qrddwebe	291	6	defense	defense	NN
cord-345472-qrddwebe	291	7	against	against	IN
cord-345472-qrddwebe	291	8	gram	gram	NN
cord-345472-qrddwebe	291	9	negative	negative	JJ
cord-345472-qrddwebe	291	10	bacterial	bacterial	JJ
cord-345472-qrddwebe	291	11	sepsis	sepsis	NN
cord-345472-qrddwebe	291	12	Myeloperoxidase	Myeloperoxidase	NNP
cord-345472-qrddwebe	291	13	is	be	VBZ
cord-345472-qrddwebe	291	14	required	require	VBN
cord-345472-qrddwebe	291	15	for	for	IN
cord-345472-qrddwebe	291	16	neutrophil	neutrophil	NN
cord-345472-qrddwebe	291	17	extracellular	extracellular	JJ
cord-345472-qrddwebe	291	18	trap	trap	NN
cord-345472-qrddwebe	291	19	formation	formation	NN
cord-345472-qrddwebe	291	20	:	:	:
cord-345472-qrddwebe	291	21	Implications	implication	NNS
cord-345472-qrddwebe	291	22	for	for	IN
cord-345472-qrddwebe	291	23	innate	innate	JJ
cord-345472-qrddwebe	291	24	immunity	immunity	NN
cord-345472-qrddwebe	291	25	Neutrophil	Neutrophil	NNP
cord-345472-qrddwebe	291	26	-	-	HYPH
cord-345472-qrddwebe	291	27	induced	induce	VBN
cord-345472-qrddwebe	291	28	genomic	genomic	JJ
cord-345472-qrddwebe	291	29	instability	instability	NN
cord-345472-qrddwebe	291	30	impedes	impede	VBZ
cord-345472-qrddwebe	291	31	resolution	resolution	NN
cord-345472-qrddwebe	291	32	of	of	IN
cord-345472-qrddwebe	291	33	inflammation	inflammation	NN
cord-345472-qrddwebe	291	34	and	and	CC
cord-345472-qrddwebe	291	35	wound	wound	VB
cord-345472-qrddwebe	291	36	healing	heal	VBG
cord-345472-qrddwebe	291	37	A	a	DT
cord-345472-qrddwebe	291	38	therapeutic	therapeutic	JJ
cord-345472-qrddwebe	291	39	role	role	NN
cord-345472-qrddwebe	291	40	for	for	IN
cord-345472-qrddwebe	291	41	matrix	matrix	NN
cord-345472-qrddwebe	291	42	metalloproteinase	metalloproteinase	NN
cord-345472-qrddwebe	291	43	inhibitors	inhibitor	NNS
cord-345472-qrddwebe	291	44	in	in	IN
cord-345472-qrddwebe	291	45	lung	lung	NN
cord-345472-qrddwebe	291	46	diseases	disease	NNS
cord-345472-qrddwebe	291	47	?	?	.
cord-345472-qrddwebe	291	48	LL-37	LL-37	NNP
cord-345472-qrddwebe	291	49	,	,	,
cord-345472-qrddwebe	291	50	the	the	DT
cord-345472-qrddwebe	291	51	only	only	JJ
cord-345472-qrddwebe	291	52	human	human	JJ
cord-345472-qrddwebe	291	53	member	member	NN
cord-345472-qrddwebe	291	54	of	of	IN
cord-345472-qrddwebe	291	55	the	the	DT
cord-345472-qrddwebe	291	56	cathelicidin	cathelicidin	NNP
cord-345472-qrddwebe	291	57	family	family	NN
cord-345472-qrddwebe	291	58	of	of	IN
cord-345472-qrddwebe	291	59	antimicrobial	antimicrobial	JJ
cord-345472-qrddwebe	291	60	peptides	peptide	NNS
cord-345472-qrddwebe	291	61	Human	Human	NNP
cord-345472-qrddwebe	291	62	neutrophil	neutrophil	NN
cord-345472-qrddwebe	291	63	collagenase	collagenase	NNP
cord-345472-qrddwebe	291	64	.	.	.
cord-345472-qrddwebe	292	1	A	a	DT
cord-345472-qrddwebe	292	2	distinct	distinct	JJ
cord-345472-qrddwebe	292	3	gene	gene	NN
cord-345472-qrddwebe	292	4	product	product	NN
cord-345472-qrddwebe	292	5	with	with	IN
cord-345472-qrddwebe	292	6	homology	homology	NN
cord-345472-qrddwebe	292	7	to	to	IN
cord-345472-qrddwebe	292	8	other	other	JJ
cord-345472-qrddwebe	292	9	matrix	matrix	NN
cord-345472-qrddwebe	292	10	metalloproteinases	metalloproteinase	NNS
cord-345472-qrddwebe	293	1	An	an	DT
cord-345472-qrddwebe	293	2	emerging	emerge	VBG
cord-345472-qrddwebe	293	3	role	role	NN
cord-345472-qrddwebe	293	4	for	for	IN
cord-345472-qrddwebe	293	5	neutrophil	neutrophil	NN
cord-345472-qrddwebe	293	6	extracellular	extracellular	JJ
cord-345472-qrddwebe	293	7	traps	trap	NNS
cord-345472-qrddwebe	293	8	in	in	IN
cord-345472-qrddwebe	293	9	noninfectious	noninfectious	JJ
cord-345472-qrddwebe	293	10	disease	disease	NN
cord-345472-qrddwebe	293	11	Neutrophils	Neutrophils	NNP
cord-345472-qrddwebe	293	12	:	:	:
cord-345472-qrddwebe	294	1	New	new	JJ
cord-345472-qrddwebe	294	2	insights	insight	NNS
cord-345472-qrddwebe	294	3	and	and	CC
cord-345472-qrddwebe	294	4	open	open	JJ
cord-345472-qrddwebe	294	5	questions	question	NNS
cord-345472-qrddwebe	295	1	Neutrophil	Neutrophil	NNP
cord-345472-qrddwebe	295	2	extracellular	extracellular	JJ
cord-345472-qrddwebe	295	3	traps	trap	NNS
cord-345472-qrddwebe	295	4	:	:	:
cord-345472-qrddwebe	296	1	The	the	DT
cord-345472-qrddwebe	296	2	biology	biology	NN
cord-345472-qrddwebe	296	3	of	of	IN
cord-345472-qrddwebe	296	4	chromatin	chromatin	NN
cord-345472-qrddwebe	296	5	externalization	externalization	NN
cord-345472-qrddwebe	297	1	The	the	DT
cord-345472-qrddwebe	297	2	pseudokinase	pseudokinase	NN
cord-345472-qrddwebe	297	3	MLKL	MLKL	NNP
cord-345472-qrddwebe	297	4	activates	activate	VBZ
cord-345472-qrddwebe	297	5	PAD4-dependent	PAD4-dependent	NNP
cord-345472-qrddwebe	297	6	NET	net	JJ
cord-345472-qrddwebe	297	7	formation	formation	NN
cord-345472-qrddwebe	297	8	in	in	IN
cord-345472-qrddwebe	297	9	necroptotic	necroptotic	JJ
cord-345472-qrddwebe	297	10	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	297	11	Infection	infection	NN
cord-345472-qrddwebe	298	1	-induced	-induced	NNP
cord-345472-qrddwebe	298	2	NETosis	NETosis	NNP
cord-345472-qrddwebe	298	3	is	be	VBZ
cord-345472-qrddwebe	298	4	a	a	DT
cord-345472-qrddwebe	298	5	dynamic	dynamic	JJ
cord-345472-qrddwebe	298	6	process	process	NN
cord-345472-qrddwebe	298	7	involving	involve	VBG
cord-345472-qrddwebe	298	8	neutrophil	neutrophil	NN
cord-345472-qrddwebe	298	9	multitasking	multitasking	NN
cord-345472-qrddwebe	298	10	in	in	IN
cord-345472-qrddwebe	298	11	vivo	vivo	NN
cord-345472-qrddwebe	299	1	Histone	histone	JJ
cord-345472-qrddwebe	299	2	hypercitrullination	hypercitrullination	NN
cord-345472-qrddwebe	299	3	mediates	mediate	VBZ
cord-345472-qrddwebe	299	4	chromatin	chromatin	VBP
cord-345472-qrddwebe	299	5	decondensation	decondensation	NN
cord-345472-qrddwebe	299	6	and	and	CC
cord-345472-qrddwebe	299	7	neutrophil	neutrophil	NN
cord-345472-qrddwebe	299	8	extracellular	extracellular	JJ
cord-345472-qrddwebe	299	9	trap	trap	NN
cord-345472-qrddwebe	299	10	formation	formation	NN
cord-345472-qrddwebe	300	1	Neutrophil	Neutrophil	NNP
cord-345472-qrddwebe	300	2	extracellular	extracellular	JJ
cord-345472-qrddwebe	300	3	traps	trap	NNS
cord-345472-qrddwebe	300	4	contain	contain	VBP
cord-345472-qrddwebe	300	5	calprotectin	calprotectin	NNS
cord-345472-qrddwebe	300	6	,	,	,
cord-345472-qrddwebe	300	7	a	a	DT
cord-345472-qrddwebe	300	8	cytosolic	cytosolic	JJ
cord-345472-qrddwebe	300	9	protein	protein	NN
cord-345472-qrddwebe	300	10	complex	complex	NN
cord-345472-qrddwebe	300	11	involved	involve	VBN
cord-345472-qrddwebe	300	12	in	in	IN
cord-345472-qrddwebe	300	13	host	host	NN
cord-345472-qrddwebe	300	14	defense	defense	NN
cord-345472-qrddwebe	300	15	against	against	IN
cord-345472-qrddwebe	300	16	Candida	Candida	NNP
cord-345472-qrddwebe	300	17	albicans	albican	NNS
cord-345472-qrddwebe	300	18	Novel	Novel	NNP
cord-345472-qrddwebe	300	19	cell	cell	NN
cord-345472-qrddwebe	300	20	death	death	NN
cord-345472-qrddwebe	300	21	program	program	NN
cord-345472-qrddwebe	300	22	leads	lead	VBZ
cord-345472-qrddwebe	300	23	to	to	IN
cord-345472-qrddwebe	300	24	neutrophil	neutrophil	VB
cord-345472-qrddwebe	300	25	extracellular	extracellular	JJ
cord-345472-qrddwebe	300	26	traps	trap	NNS
cord-345472-qrddwebe	301	1	PAD4	PAD4	NNP
cord-345472-qrddwebe	301	2	is	be	VBZ
cord-345472-qrddwebe	301	3	essential	essential	JJ
cord-345472-qrddwebe	301	4	for	for	IN
cord-345472-qrddwebe	301	5	antibacterial	antibacterial	JJ
cord-345472-qrddwebe	301	6	innate	innate	JJ
cord-345472-qrddwebe	301	7	immunity	immunity	NN
cord-345472-qrddwebe	301	8	mediated	mediate	VBN
cord-345472-qrddwebe	301	9	by	by	IN
cord-345472-qrddwebe	301	10	neutrophil	neutrophil	NN
cord-345472-qrddwebe	301	11	extracellular	extracellular	JJ
cord-345472-qrddwebe	301	12	traps	trap	NNS
cord-345472-qrddwebe	302	1	Neutrophils	neutrophils	NN
cord-345472-qrddwebe	302	2	sense	sense	NN
cord-345472-qrddwebe	302	3	microbe	microbe	NN
cord-345472-qrddwebe	302	4	size	size	NN
cord-345472-qrddwebe	302	5	and	and	CC
cord-345472-qrddwebe	302	6	selectively	selectively	RB
cord-345472-qrddwebe	302	7	release	release	VB
cord-345472-qrddwebe	302	8	neutrophil	neutrophil	NN
cord-345472-qrddwebe	302	9	extracellular	extracellular	JJ
cord-345472-qrddwebe	302	10	traps	trap	NNS
cord-345472-qrddwebe	302	11	in	in	IN
cord-345472-qrddwebe	302	12	response	response	NN
cord-345472-qrddwebe	302	13	to	to	IN
cord-345472-qrddwebe	302	14	large	large	JJ
cord-345472-qrddwebe	302	15	pathogens	pathogen	NNS
cord-345472-qrddwebe	303	1	Extracellular	Extracellular	NNP
cord-345472-qrddwebe	303	2	DNA	dna	NN
cord-345472-qrddwebe	303	3	traps	trap	NNS
cord-345472-qrddwebe	303	4	are	be	VBP
cord-345472-qrddwebe	303	5	associated	associate	VBN
cord-345472-qrddwebe	303	6	with	with	IN
cord-345472-qrddwebe	303	7	the	the	DT
cord-345472-qrddwebe	303	8	pathogenesis	pathogenesis	NN
cord-345472-qrddwebe	303	9	of	of	IN
cord-345472-qrddwebe	303	10	TRALI	TRALI	NNP
cord-345472-qrddwebe	303	11	in	in	IN
cord-345472-qrddwebe	303	12	humans	human	NNS
cord-345472-qrddwebe	303	13	and	and	CC
cord-345472-qrddwebe	303	14	mice	mouse	NNS
cord-345472-qrddwebe	303	15	Host	Host	NNP
cord-345472-qrddwebe	303	16	DNA	DNA	NNP
cord-345472-qrddwebe	303	17	released	release	VBN
cord-345472-qrddwebe	303	18	by	by	IN
cord-345472-qrddwebe	303	19	NETosis	NETosis	NNP
cord-345472-qrddwebe	303	20	promotes	promote	VBZ
cord-345472-qrddwebe	303	21	rhinovirus	rhinovirus	NN
cord-345472-qrddwebe	303	22	-	-	HYPH
cord-345472-qrddwebe	303	23	induced	induce	VBN
cord-345472-qrddwebe	303	24	type-2	type-2	NN
cord-345472-qrddwebe	303	25	allergic	allergic	JJ
cord-345472-qrddwebe	303	26	asthma	asthma	NN
cord-345472-qrddwebe	303	27	exacerbation	exacerbation	NN
cord-345472-qrddwebe	303	28	Peptidylarginine	Peptidylarginine	NNP
cord-345472-qrddwebe	303	29	deiminase	deiminase	NN
cord-345472-qrddwebe	303	30	inhibition	inhibition	NN
cord-345472-qrddwebe	303	31	is	be	VBZ
cord-345472-qrddwebe	303	32	immunomodulatory	immunomodulatory	JJ
cord-345472-qrddwebe	303	33	and	and	CC
cord-345472-qrddwebe	303	34	vasculoprotective	vasculoprotective	NN
cord-345472-qrddwebe	303	35	in	in	IN
cord-345472-qrddwebe	303	36	murine	murine	JJ
cord-345472-qrddwebe	303	37	lupus	lupus	NN
cord-345472-qrddwebe	303	38	Effect	effect	NN
cord-345472-qrddwebe	303	39	of	of	IN
cord-345472-qrddwebe	303	40	interleukin-6	interleukin-6	NNP
cord-345472-qrddwebe	303	41	receptor	receptor	NN
cord-345472-qrddwebe	303	42	inhibition	inhibition	NN
cord-345472-qrddwebe	303	43	with	with	IN
cord-345472-qrddwebe	303	44	tocilizumab	tocilizumab	NNP
cord-345472-qrddwebe	303	45	in	in	IN
cord-345472-qrddwebe	303	46	patients	patient	NNS
cord-345472-qrddwebe	303	47	with	with	IN
cord-345472-qrddwebe	303	48	rheumatoid	rheumatoid	NN
cord-345472-qrddwebe	303	49	arthritis	arthritis	NN
cord-345472-qrddwebe	303	50	(	(	-LRB-
cord-345472-qrddwebe	303	51	OPTION	option	NN
cord-345472-qrddwebe	303	52	study	study	NN
cord-345472-qrddwebe	303	53	)	)	-RRB-
cord-345472-qrddwebe	303	54	:	:	:
cord-345472-qrddwebe	303	55	A	a	DT
cord-345472-qrddwebe	303	56	double	double	JJ
cord-345472-qrddwebe	303	57	-	-	HYPH
cord-345472-qrddwebe	303	58	blind	blind	JJ
cord-345472-qrddwebe	303	59	,	,	,
cord-345472-qrddwebe	303	60	placebo	placebo	NN
cord-345472-qrddwebe	303	61	-	-	HYPH
cord-345472-qrddwebe	303	62	controlled	control	VBN
cord-345472-qrddwebe	303	63	,	,	,
cord-345472-qrddwebe	303	64	randomised	randomised	JJ
cord-345472-qrddwebe	303	65	trial	trial	NN
cord-345472-qrddwebe	304	1	CXCR2	CXCR2	NNP
cord-345472-qrddwebe	304	2	mediates	mediate	VBZ
cord-345472-qrddwebe	304	3	NADPH	NADPH	NNP
cord-345472-qrddwebe	304	4	oxidase	oxidase	NN
cord-345472-qrddwebe	304	5	-	-	HYPH
cord-345472-qrddwebe	304	6	independent	independent	JJ
cord-345472-qrddwebe	304	7	neutrophil	neutrophil	NN
cord-345472-qrddwebe	304	8	extracellular	extracellular	JJ
cord-345472-qrddwebe	304	9	trap	trap	NN
cord-345472-qrddwebe	304	10	formation	formation	NN
cord-345472-qrddwebe	304	11	in	in	IN
cord-345472-qrddwebe	304	12	cystic	cystic	JJ
cord-345472-qrddwebe	304	13	fibrosis	fibrosis	NN
cord-345472-qrddwebe	304	14	airway	airway	NN
cord-345472-qrddwebe	304	15	inflammation	inflammation	NN
cord-345472-qrddwebe	304	16	Neutrophils	neutrophil	NNS
cord-345472-qrddwebe	304	17	and	and	CC
cord-345472-qrddwebe	304	18	immunity	immunity	NN
cord-345472-qrddwebe	304	19	:	:	:
cord-345472-qrddwebe	305	1	Challenges	challenge	NNS
cord-345472-qrddwebe	305	2	and	and	CC
cord-345472-qrddwebe	305	3	opportunities	opportunity	NNS
cord-345472-qrddwebe	305	4	Toll	toll	NN
cord-345472-qrddwebe	305	5	-	-	HYPH
cord-345472-qrddwebe	305	6	like	like	JJ
cord-345472-qrddwebe	305	7	receptors	receptor	NNS
cord-345472-qrddwebe	305	8	stimulate	stimulate	VBP
cord-345472-qrddwebe	305	9	human	human	JJ
cord-345472-qrddwebe	305	10	neutrophil	neutrophil	NN
cord-345472-qrddwebe	305	11	function	function	NN
cord-345472-qrddwebe	305	12	Activation	activation	NN
cord-345472-qrddwebe	305	13	of	of	IN
cord-345472-qrddwebe	305	14	an	an	DT
cord-345472-qrddwebe	305	15	immunoregulatory	immunoregulatory	JJ
cord-345472-qrddwebe	305	16	and	and	CC
cord-345472-qrddwebe	305	17	antiviral	antiviral	JJ
cord-345472-qrddwebe	305	18	gene	gene	NN
cord-345472-qrddwebe	305	19	expression	expression	NN
cord-345472-qrddwebe	305	20	program	program	NN
cord-345472-qrddwebe	305	21	in	in	IN
cord-345472-qrddwebe	305	22	poly(I	poly(I	NNP
cord-345472-qrddwebe	305	23	:	:	:
cord-345472-qrddwebe	306	1	C)-transfected	C)-transfected	NNP
cord-345472-qrddwebe	306	2	human	human	JJ
cord-345472-qrddwebe	306	3	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	306	4	Recognition	Recognition	NNP
cord-345472-qrddwebe	306	5	of	of	IN
cord-345472-qrddwebe	306	6	peptidoglycan	peptidoglycan	NN
cord-345472-qrddwebe	306	7	from	from	IN
cord-345472-qrddwebe	306	8	the	the	DT
cord-345472-qrddwebe	306	9	microbiota	microbiota	NN
cord-345472-qrddwebe	306	10	by	by	IN
cord-345472-qrddwebe	306	11	Nod1	Nod1	NNP
cord-345472-qrddwebe	306	12	enhances	enhance	VBZ
cord-345472-qrddwebe	306	13	systemic	systemic	JJ
cord-345472-qrddwebe	306	14	innate	innate	JJ
cord-345472-qrddwebe	306	15	immunity	immunity	NN
cord-345472-qrddwebe	306	16	S100A9	s100a9	NN
cord-345472-qrddwebe	306	17	and	and	CC
cord-345472-qrddwebe	306	18	S100A12	s100a12	NN
cord-345472-qrddwebe	306	19	activate	activate	VBP
cord-345472-qrddwebe	306	20	airway	airway	NN
cord-345472-qrddwebe	306	21	epithelial	epithelial	JJ
cord-345472-qrddwebe	306	22	cells	cell	NNS
cord-345472-qrddwebe	306	23	to	to	TO
cord-345472-qrddwebe	306	24	produce	produce	VB
cord-345472-qrddwebe	306	25	MUC5AC	MUC5AC	NNP
cord-345472-qrddwebe	306	26	via	via	IN
cord-345472-qrddwebe	306	27	extracellular	extracellular	JJ
cord-345472-qrddwebe	306	28	signal	signal	NN
cord-345472-qrddwebe	306	29	-	-	HYPH
cord-345472-qrddwebe	306	30	regulated	regulate	VBN
cord-345472-qrddwebe	306	31	kinase	kinase	NN
cord-345472-qrddwebe	306	32	and	and	CC
cord-345472-qrddwebe	306	33	nuclear	nuclear	JJ
cord-345472-qrddwebe	306	34	factor	factor	NN
cord-345472-qrddwebe	306	35	-	-	:
cord-345472-qrddwebe	306	36	kappaB	kappaB	NNP
cord-345472-qrddwebe	306	37	pathways	pathway	NNS
cord-345472-qrddwebe	306	38	Secretion	secretion	NN
cord-345472-qrddwebe	306	39	of	of	IN
cord-345472-qrddwebe	306	40	S100A8	S100A8	NNP
cord-345472-qrddwebe	306	41	,	,	,
cord-345472-qrddwebe	306	42	S100A9	S100A9	NNP
cord-345472-qrddwebe	306	43	,	,	,
cord-345472-qrddwebe	306	44	and	and	CC
cord-345472-qrddwebe	306	45	S100A12	s100a12	NN
cord-345472-qrddwebe	306	46	by	by	IN
cord-345472-qrddwebe	306	47	Neutrophils	Neutrophils	NNP
cord-345472-qrddwebe	307	1	Involves	involve	VBZ
cord-345472-qrddwebe	307	2	Reactive	reactive	JJ
cord-345472-qrddwebe	307	3	Oxygen	Oxygen	NNP
cord-345472-qrddwebe	307	4	Species	Species	NNPS
cord-345472-qrddwebe	307	5	and	and	CC
cord-345472-qrddwebe	307	6	Potassium	Potassium	NNP
cord-345472-qrddwebe	307	7	Efflux	Efflux	NNP
cord-345472-qrddwebe	307	8	Interleukin	Interleukin	NNP
cord-345472-qrddwebe	308	1	(	(	-LRB-
cord-345472-qrddwebe	308	2	IL)-22	il)-22	NN
cord-345472-qrddwebe	308	3	and	and	CC
cord-345472-qrddwebe	308	4	IL-17	IL-17	NNP
cord-345472-qrddwebe	308	5	are	be	VBP
cord-345472-qrddwebe	308	6	coexpressed	coexpresse	VBN
cord-345472-qrddwebe	308	7	by	by	IN
cord-345472-qrddwebe	308	8	Th17	Th17	NNP
cord-345472-qrddwebe	308	9	cells	cell	NNS
cord-345472-qrddwebe	308	10	and	and	CC
cord-345472-qrddwebe	308	11	cooperatively	cooperatively	RB
cord-345472-qrddwebe	308	12	enhance	enhance	VB
cord-345472-qrddwebe	308	13	expression	expression	NN
cord-345472-qrddwebe	308	14	of	of	IN
cord-345472-qrddwebe	308	15	antimicrobial	antimicrobial	JJ
cord-345472-qrddwebe	308	16	peptides	peptide	NNS
cord-345472-qrddwebe	308	17	Neutrophils	Neutrophils	NNPS
cord-345472-qrddwebe	308	18	mediate	mediate	VBP
cord-345472-qrddwebe	308	19	immune	immune	JJ
cord-345472-qrddwebe	308	20	modulation	modulation	NN
cord-345472-qrddwebe	308	21	of	of	IN
cord-345472-qrddwebe	308	22	dendritic	dendritic	JJ
cord-345472-qrddwebe	308	23	cells	cell	NNS
cord-345472-qrddwebe	308	24	through	through	IN
cord-345472-qrddwebe	308	25	glycosylation	glycosylation	NN
cord-345472-qrddwebe	308	26	-	-	HYPH
cord-345472-qrddwebe	308	27	dependent	dependent	JJ
cord-345472-qrddwebe	308	28	interactions	interaction	NNS
cord-345472-qrddwebe	308	29	between	between	IN
cord-345472-qrddwebe	308	30	Mac-1	Mac-1	NNP
cord-345472-qrddwebe	308	31	and	and	CC
cord-345472-qrddwebe	308	32	DC	DC	NNP
cord-345472-qrddwebe	308	33	-	-	HYPH
cord-345472-qrddwebe	308	34	SIGN	SIGN	NNP
cord-345472-qrddwebe	308	35	Neutrophil	Neutrophil	NNP
cord-345472-qrddwebe	308	36	cytoplasts	cytoplast	NNS
cord-345472-qrddwebe	308	37	induce	induce	VBP
cord-345472-qrddwebe	308	38	TH17	TH17	NNP
cord-345472-qrddwebe	308	39	differentiation	differentiation	NN
cord-345472-qrddwebe	308	40	and	and	CC
cord-345472-qrddwebe	308	41	skew	skew	VB
cord-345472-qrddwebe	308	42	inflammation	inflammation	NN
cord-345472-qrddwebe	308	43	toward	toward	IN
cord-345472-qrddwebe	308	44	neutrophilia	neutrophilia	NN
cord-345472-qrddwebe	308	45	in	in	IN
cord-345472-qrddwebe	308	46	severe	severe	JJ
cord-345472-qrddwebe	308	47	asthma	asthma	NN
cord-345472-qrddwebe	308	48	Neutrophils	Neutrophils	NNP
cord-345472-qrddwebe	308	49	acquire	acquire	VBP
cord-345472-qrddwebe	308	50	the	the	DT
cord-345472-qrddwebe	308	51	capacity	capacity	NN
cord-345472-qrddwebe	308	52	for	for	IN
cord-345472-qrddwebe	308	53	antigen	antigen	NN
cord-345472-qrddwebe	308	54	presentation	presentation	NN
cord-345472-qrddwebe	308	55	to	to	IN
cord-345472-qrddwebe	308	56	memory	memory	NN
cord-345472-qrddwebe	308	57	CD4(+	CD4(+	NNP
cord-345472-qrddwebe	308	58	)	)	-RRB-
cord-345472-qrddwebe	309	1	T	T	NNP
cord-345472-qrddwebe	309	2	cells	cell	NNS
cord-345472-qrddwebe	309	3	in	in	IN
cord-345472-qrddwebe	309	4	vitro	vitro	FW
cord-345472-qrddwebe	309	5	and	and	CC
cord-345472-qrddwebe	309	6	ex	ex	FW
cord-345472-qrddwebe	309	7	vivo	vivo	NN
cord-345472-qrddwebe	310	1	An	an	DT
cord-345472-qrddwebe	310	2	in	in	IN
cord-345472-qrddwebe	310	3	vitro	vitro	FW
cord-345472-qrddwebe	310	4	transepithelial	transepithelial	JJ
cord-345472-qrddwebe	310	5	migration	migration	NN
cord-345472-qrddwebe	310	6	assay	assay	NN
cord-345472-qrddwebe	310	7	to	to	TO
cord-345472-qrddwebe	310	8	evaluate	evaluate	VB
cord-345472-qrddwebe	310	9	the	the	DT
cord-345472-qrddwebe	310	10	role	role	NN
cord-345472-qrddwebe	310	11	of	of	IN
cord-345472-qrddwebe	310	12	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	310	13	in	in	IN
cord-345472-qrddwebe	310	14	Respiratory	respiratory	JJ
cord-345472-qrddwebe	310	15	Syncytial	Syncytial	NNP
cord-345472-qrddwebe	310	16	Virus	virus	NN
cord-345472-qrddwebe	310	17	(	(	-LRB-
cord-345472-qrddwebe	310	18	RSV	RSV	NNP
cord-345472-qrddwebe	310	19	)	)	-RRB-
cord-345472-qrddwebe	310	20	induced	induce	VBN
cord-345472-qrddwebe	310	21	epithelial	epithelial	JJ
cord-345472-qrddwebe	310	22	damage	damage	NN
cord-345472-qrddwebe	310	23	Respiratory	respiratory	JJ
cord-345472-qrddwebe	310	24	syncytial	syncytial	JJ
cord-345472-qrddwebe	310	25	virus	virus	NN
cord-345472-qrddwebe	310	26	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	310	27	in	in	IN
cord-345472-qrddwebe	310	28	infancy	infancy	NN
cord-345472-qrddwebe	310	29	is	be	VBZ
cord-345472-qrddwebe	310	30	an	an	DT
cord-345472-qrddwebe	310	31	important	important	JJ
cord-345472-qrddwebe	310	32	risk	risk	NN
cord-345472-qrddwebe	310	33	factor	factor	NN
cord-345472-qrddwebe	310	34	for	for	IN
cord-345472-qrddwebe	310	35	asthma	asthma	NN
cord-345472-qrddwebe	310	36	and	and	CC
cord-345472-qrddwebe	310	37	allergy	allergy	NN
cord-345472-qrddwebe	310	38	at	at	IN
cord-345472-qrddwebe	310	39	age	age	NN
cord-345472-qrddwebe	310	40	7	7	CD
cord-345472-qrddwebe	310	41	Respiratory	respiratory	JJ
cord-345472-qrddwebe	310	42	syncytial	syncytial	JJ
cord-345472-qrddwebe	310	43	virus	virus	NN
cord-345472-qrddwebe	310	44	in	in	IN
cord-345472-qrddwebe	310	45	early	early	JJ
cord-345472-qrddwebe	310	46	life	life	NN
cord-345472-qrddwebe	310	47	and	and	CC
cord-345472-qrddwebe	310	48	risk	risk	NN
cord-345472-qrddwebe	310	49	of	of	IN
cord-345472-qrddwebe	310	50	wheeze	wheeze	NN
cord-345472-qrddwebe	310	51	and	and	CC
cord-345472-qrddwebe	310	52	allergy	allergy	NN
cord-345472-qrddwebe	310	53	by	by	IN
cord-345472-qrddwebe	310	54	age	age	NN
cord-345472-qrddwebe	310	55	13	13	CD
cord-345472-qrddwebe	310	56	years	year	NNS
cord-345472-qrddwebe	311	1	IL-1alpha	il-1alpha	UH
cord-345472-qrddwebe	311	2	,	,	,
cord-345472-qrddwebe	311	3	IL-33	IL-33	NNP
cord-345472-qrddwebe	311	4	and	and	CC
cord-345472-qrddwebe	311	5	S100	S100	NNP
cord-345472-qrddwebe	311	6	proteins	protein	NNS
cord-345472-qrddwebe	311	7	:	:	:
cord-345472-qrddwebe	312	1	Dual	dual	JJ
cord-345472-qrddwebe	312	2	-	-	HYPH
cord-345472-qrddwebe	312	3	function	function	NN
cord-345472-qrddwebe	312	4	alarmins	alarmin	VBZ
cord-345472-qrddwebe	312	5	Respiratory	respiratory	JJ
cord-345472-qrddwebe	312	6	syncytial	syncytial	JJ
cord-345472-qrddwebe	312	7	virus	virus	NN
cord-345472-qrddwebe	312	8	infection	infection	NN
cord-345472-qrddwebe	312	9	promotes	promote	VBZ
cord-345472-qrddwebe	312	10	necroptosis	necroptosis	NNP
cord-345472-qrddwebe	312	11	and	and	CC
cord-345472-qrddwebe	312	12	hmgb1	hmgb1	NNP
cord-345472-qrddwebe	312	13	release	release	NNP
cord-345472-qrddwebe	312	14	by	by	IN
cord-345472-qrddwebe	312	15	airway	airway	NN
cord-345472-qrddwebe	312	16	epithelial	epithelial	JJ
cord-345472-qrddwebe	312	17	cells	cell	NNS
cord-345472-qrddwebe	312	18	Animal	animal	NN
cord-345472-qrddwebe	312	19	models	model	NNS
cord-345472-qrddwebe	312	20	of	of	IN
cord-345472-qrddwebe	312	21	human	human	JJ
cord-345472-qrddwebe	312	22	respiratory	respiratory	JJ
cord-345472-qrddwebe	312	23	syncytial	syncytial	JJ
cord-345472-qrddwebe	312	24	virus	virus	NN
cord-345472-qrddwebe	312	25	disease	disease	NN
cord-345472-qrddwebe	312	26	Animal	Animal	NNP
cord-345472-qrddwebe	312	27	models	model	NNS
cord-345472-qrddwebe	312	28	of	of	IN
cord-345472-qrddwebe	312	29	respiratory	respiratory	JJ
cord-345472-qrddwebe	312	30	syncytial	syncytial	JJ
cord-345472-qrddwebe	312	31	virus	virus	NN
cord-345472-qrddwebe	312	32	infection	infection	NN
cord-345472-qrddwebe	312	33	Animal	Animal	NNP
cord-345472-qrddwebe	312	34	models	model	NNS
cord-345472-qrddwebe	312	35	of	of	IN
cord-345472-qrddwebe	312	36	respiratory	respiratory	JJ
cord-345472-qrddwebe	312	37	syncytial	syncytial	JJ
cord-345472-qrddwebe	312	38	virus	virus	NN
cord-345472-qrddwebe	312	39	infection	infection	NN
cord-345472-qrddwebe	312	40	and	and	CC
cord-345472-qrddwebe	312	41	disease	disease	NN
cord-345472-qrddwebe	312	42	Plasmacytoid	Plasmacytoid	NNP
cord-345472-qrddwebe	312	43	dendritic	dendritic	JJ
cord-345472-qrddwebe	312	44	cells	cell	NNS
cord-345472-qrddwebe	312	45	protect	protect	VBP
cord-345472-qrddwebe	312	46	from	from	IN
cord-345472-qrddwebe	312	47	viral	viral	JJ
cord-345472-qrddwebe	312	48	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	312	49	and	and	CC
cord-345472-qrddwebe	312	50	asthma	asthma	NN
cord-345472-qrddwebe	312	51	through	through	IN
cord-345472-qrddwebe	312	52	semaphorin	semaphorin	NNP
cord-345472-qrddwebe	312	53	4a	4a	CD
cord-345472-qrddwebe	312	54	-	-	HYPH
cord-345472-qrddwebe	312	55	mediated	mediate	VBN
cord-345472-qrddwebe	312	56	T	T	NNP
cord-345472-qrddwebe	312	57	reg	reg	NN
cord-345472-qrddwebe	312	58	expansion	expansion	NN
cord-345472-qrddwebe	312	59	Toll	Toll	NNP
cord-345472-qrddwebe	312	60	-	-	HYPH
cord-345472-qrddwebe	312	61	like	like	JJ
cord-345472-qrddwebe	312	62	receptor	receptor	NN
cord-345472-qrddwebe	312	63	7	7	CD
cord-345472-qrddwebe	312	64	gene	gene	NN
cord-345472-qrddwebe	312	65	deficiency	deficiency	NN
cord-345472-qrddwebe	312	66	and	and	CC
cord-345472-qrddwebe	312	67	early	early	JJ
cord-345472-qrddwebe	312	68	-	-	HYPH
cord-345472-qrddwebe	312	69	life	life	NN
cord-345472-qrddwebe	312	70	Pneumovirus	Pneumovirus	NNP
cord-345472-qrddwebe	312	71	infection	infection	NN
cord-345472-qrddwebe	312	72	interact	interact	VBP
cord-345472-qrddwebe	312	73	to	to	TO
cord-345472-qrddwebe	312	74	predispose	predispose	VB
cord-345472-qrddwebe	312	75	toward	toward	IN
cord-345472-qrddwebe	312	76	the	the	DT
cord-345472-qrddwebe	312	77	development	development	NN
cord-345472-qrddwebe	312	78	of	of	IN
cord-345472-qrddwebe	312	79	asthma	asthma	NN
cord-345472-qrddwebe	312	80	-	-	HYPH
cord-345472-qrddwebe	312	81	like	like	JJ
cord-345472-qrddwebe	312	82	pathology	pathology	NN
cord-345472-qrddwebe	312	83	in	in	IN
cord-345472-qrddwebe	312	84	mice	mouse	NNS
cord-345472-qrddwebe	313	1	Plasmacytoid	Plasmacytoid	NNP
cord-345472-qrddwebe	313	2	dendritic	dendritic	JJ
cord-345472-qrddwebe	313	3	cells	cell	NNS
cord-345472-qrddwebe	313	4	promote	promote	VBP
cord-345472-qrddwebe	313	5	host	host	NN
cord-345472-qrddwebe	313	6	defense	defense	NN
cord-345472-qrddwebe	313	7	against	against	IN
cord-345472-qrddwebe	313	8	acute	acute	JJ
cord-345472-qrddwebe	313	9	pneumovirus	pneumovirus	NNP
cord-345472-qrddwebe	313	10	infection	infection	NN
cord-345472-qrddwebe	313	11	via	via	IN
cord-345472-qrddwebe	313	12	the	the	DT
cord-345472-qrddwebe	313	13	TLR7-MyD88-dependent	tlr7-myd88-dependent	NN
cord-345472-qrddwebe	314	1	signaling	signal	VBG
cord-345472-qrddwebe	314	2	pathway	pathway	NN
cord-345472-qrddwebe	314	3	HMGB1	HMGB1	NNP
cord-345472-qrddwebe	314	4	amplifies	amplify	VBZ
cord-345472-qrddwebe	314	5	ILC2-induced	ilc2-induce	VBN
cord-345472-qrddwebe	315	1	type-2	type-2	NN
cord-345472-qrddwebe	315	2	inflammation	inflammation	NN
cord-345472-qrddwebe	315	3	and	and	CC
cord-345472-qrddwebe	315	4	airway	airway	NN
cord-345472-qrddwebe	315	5	smooth	smooth	JJ
cord-345472-qrddwebe	315	6	muscle	muscle	NN
cord-345472-qrddwebe	315	7	remodelling	remodelle	VBG
cord-345472-qrddwebe	315	8	Plasmacytoid	Plasmacytoid	NNP
cord-345472-qrddwebe	315	9	dendritic	dendritic	JJ
cord-345472-qrddwebe	315	10	cells	cell	NNS
cord-345472-qrddwebe	315	11	during	during	IN
cord-345472-qrddwebe	315	12	infancy	infancy	NN
cord-345472-qrddwebe	315	13	are	be	VBP
cord-345472-qrddwebe	315	14	inversely	inversely	RB
cord-345472-qrddwebe	315	15	associated	associate	VBN
cord-345472-qrddwebe	315	16	with	with	IN
cord-345472-qrddwebe	315	17	childhood	childhood	NN
cord-345472-qrddwebe	315	18	respiratory	respiratory	JJ
cord-345472-qrddwebe	315	19	tract	tract	NN
cord-345472-qrddwebe	315	20	infections	infection	NNS
cord-345472-qrddwebe	315	21	and	and	CC
cord-345472-qrddwebe	315	22	wheezing	wheeze	VBG
cord-345472-qrddwebe	315	23	IL-8	il-8	NN
cord-345472-qrddwebe	315	24	)	)	-RRB-
cord-345472-qrddwebe	315	25	mediates	mediate	VBZ
cord-345472-qrddwebe	315	26	neutrophil	neutrophil	NN
cord-345472-qrddwebe	315	27	recruitment	recruitment	NN
cord-345472-qrddwebe	315	28	and	and	CC
cord-345472-qrddwebe	315	29	behavior	behavior	NN
cord-345472-qrddwebe	315	30	in	in	IN
cord-345472-qrddwebe	315	31	the	the	DT
cord-345472-qrddwebe	315	32	zebrafish	zebrafish	NN
cord-345472-qrddwebe	315	33	inflammatory	inflammatory	JJ
cord-345472-qrddwebe	315	34	response	response	NN
cord-345472-qrddwebe	316	1	Leukotriene	Leukotriene	NNP
cord-345472-qrddwebe	316	2	B4-mediated	b4-mediate	VBN
cord-345472-qrddwebe	317	1	neutrophil	neutrophil	NN
cord-345472-qrddwebe	317	2	recruitment	recruitment	NN
cord-345472-qrddwebe	317	3	causes	cause	VBZ
cord-345472-qrddwebe	317	4	pulmonary	pulmonary	JJ
cord-345472-qrddwebe	317	5	capillaritis	capillaritis	NN
cord-345472-qrddwebe	317	6	during	during	IN
cord-345472-qrddwebe	317	7	lethal	lethal	JJ
cord-345472-qrddwebe	317	8	fungal	fungal	NN
cord-345472-qrddwebe	317	9	sepsis	sepsis	NN
cord-345472-qrddwebe	318	1	IL-8	IL-8	NNP
cord-345472-qrddwebe	318	2	/	/	,
cord-345472-qrddwebe	318	3	IL-17	IL-17	NNP
cord-345472-qrddwebe	318	4	gene	gene	NN
cord-345472-qrddwebe	318	5	variations	variation	NNS
cord-345472-qrddwebe	318	6	and	and	CC
cord-345472-qrddwebe	318	7	the	the	DT
cord-345472-qrddwebe	318	8	susceptibility	susceptibility	NN
cord-345472-qrddwebe	318	9	to	to	IN
cord-345472-qrddwebe	318	10	severe	severe	JJ
cord-345472-qrddwebe	318	11	viral	viral	JJ
cord-345472-qrddwebe	318	12	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	318	13	Randomized	randomized	JJ
cord-345472-qrddwebe	318	14	trial	trial	NN
cord-345472-qrddwebe	318	15	to	to	TO
cord-345472-qrddwebe	318	16	evaluate	evaluate	VB
cord-345472-qrddwebe	318	17	azithromycin	azithromycin	NNP
cord-345472-qrddwebe	318	18	's	's	POS
cord-345472-qrddwebe	318	19	effects	effect	NNS
cord-345472-qrddwebe	318	20	on	on	IN
cord-345472-qrddwebe	318	21	serum	serum	NN
cord-345472-qrddwebe	318	22	and	and	CC
cord-345472-qrddwebe	318	23	upper	upper	JJ
cord-345472-qrddwebe	318	24	airway	airway	NN
cord-345472-qrddwebe	318	25	IL-8	il-8	NN
cord-345472-qrddwebe	318	26	levels	level	NNS
cord-345472-qrddwebe	318	27	and	and	CC
cord-345472-qrddwebe	318	28	recurrent	recurrent	JJ
cord-345472-qrddwebe	318	29	wheezing	wheezing	NN
cord-345472-qrddwebe	318	30	in	in	IN
cord-345472-qrddwebe	318	31	infants	infant	NNS
cord-345472-qrddwebe	318	32	with	with	IN
cord-345472-qrddwebe	318	33	respiratory	respiratory	JJ
cord-345472-qrddwebe	318	34	syncytial	syncytial	JJ
cord-345472-qrddwebe	318	35	virus	virus	NN
cord-345472-qrddwebe	318	36	bronchiolitis	bronchioliti	VBD
cord-345472-qrddwebe	318	37	Airway	Airway	NNP
cord-345472-qrddwebe	318	38	eicosanoids	eicosanoid	NNS
cord-345472-qrddwebe	318	39	in	in	IN
cord-345472-qrddwebe	318	40	acute	acute	JJ
cord-345472-qrddwebe	318	41	severe	severe	JJ
cord-345472-qrddwebe	318	42	respiratory	respiratory	JJ
cord-345472-qrddwebe	318	43	syncytial	syncytial	JJ
cord-345472-qrddwebe	318	44	virus	virus	NN
cord-345472-qrddwebe	318	45	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	318	46	Neutrophil	Neutrophil	NNP
cord-345472-qrddwebe	318	47	swarms	swarm	NNS
cord-345472-qrddwebe	318	48	require	require	VBP
cord-345472-qrddwebe	318	49	LTB4	LTB4	NNP
cord-345472-qrddwebe	318	50	and	and	CC
cord-345472-qrddwebe	318	51	integrins	integrin	NNS
cord-345472-qrddwebe	318	52	at	at	IN
cord-345472-qrddwebe	318	53	sites	site	NNS
cord-345472-qrddwebe	318	54	of	of	IN
cord-345472-qrddwebe	318	55	cell	cell	NN
cord-345472-qrddwebe	318	56	death	death	NN
cord-345472-qrddwebe	318	57	in	in	IN
cord-345472-qrddwebe	318	58	vivo	vivo	NNP
cord-345472-qrddwebe	318	59	Zileuton	Zileuton	NNP
cord-345472-qrddwebe	318	60	reduces	reduce	VBZ
cord-345472-qrddwebe	318	61	respiratory	respiratory	JJ
cord-345472-qrddwebe	318	62	illness	illness	NN
cord-345472-qrddwebe	318	63	and	and	CC
cord-345472-qrddwebe	318	64	lung	lung	NN
cord-345472-qrddwebe	318	65	inflammation	inflammation	NN
cord-345472-qrddwebe	318	66	,	,	,
cord-345472-qrddwebe	318	67	during	during	IN
cord-345472-qrddwebe	318	68	respiratory	respiratory	JJ
cord-345472-qrddwebe	318	69	syncytial	syncytial	JJ
cord-345472-qrddwebe	318	70	virus	virus	NN
cord-345472-qrddwebe	318	71	infection	infection	NN
cord-345472-qrddwebe	318	72	,	,	,
cord-345472-qrddwebe	318	73	in	in	IN
cord-345472-qrddwebe	318	74	mice	mouse	NNS
cord-345472-qrddwebe	318	75	Interferon	interferon	NN
cord-345472-qrddwebe	318	76	-	-	HYPH
cord-345472-qrddwebe	318	77	gamma	gamma	NN
cord-345472-qrddwebe	318	78	coordinates	coordinate	VBZ
cord-345472-qrddwebe	318	79	CCL3-mediated	CCL3-mediated	NNP
cord-345472-qrddwebe	318	80	neutrophil	neutrophil	NN
cord-345472-qrddwebe	318	81	recruitment	recruitment	NN
cord-345472-qrddwebe	318	82	in	in	IN
cord-345472-qrddwebe	318	83	vivo	vivo	NNP
cord-345472-qrddwebe	319	1	The	the	DT
cord-345472-qrddwebe	319	2	chemokine	chemokine	NN
cord-345472-qrddwebe	319	3	macrophage	macrophage	NN
cord-345472-qrddwebe	319	4	-	-	HYPH
cord-345472-qrddwebe	319	5	inflammatory	inflammatory	JJ
cord-345472-qrddwebe	319	6	protein-1	protein-1	NNP
cord-345472-qrddwebe	319	7	alpha	alpha	NN
cord-345472-qrddwebe	319	8	and	and	CC
cord-345472-qrddwebe	319	9	its	-PRON-	PRP$
cord-345472-qrddwebe	319	10	receptor	receptor	NN
cord-345472-qrddwebe	319	11	CCR1	CCR1	NNP
cord-345472-qrddwebe	319	12	control	control	NN
cord-345472-qrddwebe	319	13	pulmonary	pulmonary	JJ
cord-345472-qrddwebe	319	14	inflammation	inflammation	NN
cord-345472-qrddwebe	319	15	and	and	CC
cord-345472-qrddwebe	319	16	antiviral	antiviral	JJ
cord-345472-qrddwebe	319	17	host	host	NN
cord-345472-qrddwebe	319	18	defense	defense	NN
cord-345472-qrddwebe	319	19	in	in	IN
cord-345472-qrddwebe	319	20	paramyxovirus	paramyxovirus	JJ
cord-345472-qrddwebe	319	21	infection	infection	NN
cord-345472-qrddwebe	319	22	Altered	alter	VBD
cord-345472-qrddwebe	319	23	pathogenesis	pathogenesis	NN
cord-345472-qrddwebe	319	24	of	of	IN
cord-345472-qrddwebe	319	25	severe	severe	JJ
cord-345472-qrddwebe	319	26	pneumovirus	pneumovirus	JJ
cord-345472-qrddwebe	319	27	infection	infection	NN
cord-345472-qrddwebe	319	28	in	in	IN
cord-345472-qrddwebe	319	29	response	response	NN
cord-345472-qrddwebe	319	30	to	to	IN
cord-345472-qrddwebe	319	31	combined	combine	VBN
cord-345472-qrddwebe	319	32	antiviral	antiviral	JJ
cord-345472-qrddwebe	319	33	and	and	CC
cord-345472-qrddwebe	319	34	specific	specific	JJ
cord-345472-qrddwebe	319	35	immunomodulatory	immunomodulatory	JJ
cord-345472-qrddwebe	319	36	agents	agent	NNS
cord-345472-qrddwebe	320	1	Allergen	allergen	NN
cord-345472-qrddwebe	320	2	-	-	HYPH
cord-345472-qrddwebe	320	3	induced	induce	VBN
cord-345472-qrddwebe	320	4	IL-6	IL-6	NNP
cord-345472-qrddwebe	320	5	trans	trans	NNP
cord-345472-qrddwebe	320	6	-	-	NN
cord-345472-qrddwebe	320	7	signaling	signal	VBG
cord-345472-qrddwebe	320	8	activates	activate	VBZ
cord-345472-qrddwebe	320	9	gammadelta	gammadelta	NNP
cord-345472-qrddwebe	320	10	T	T	NNP
cord-345472-qrddwebe	320	11	cells	cell	NNS
cord-345472-qrddwebe	320	12	to	to	TO
cord-345472-qrddwebe	320	13	promote	promote	VB
cord-345472-qrddwebe	320	14	type	type	NN
cord-345472-qrddwebe	320	15	2	2	CD
cord-345472-qrddwebe	320	16	and	and	CC
cord-345472-qrddwebe	320	17	type	type	VB
cord-345472-qrddwebe	320	18	17	17	CD
cord-345472-qrddwebe	320	19	airway	airway	NN
cord-345472-qrddwebe	320	20	inflammation	inflammation	NN
cord-345472-qrddwebe	320	21	Interleukin-1	Interleukin-1	NNP
cord-345472-qrddwebe	320	22	and	and	CC
cord-345472-qrddwebe	320	23	IL-23	IL-23	NNP
cord-345472-qrddwebe	320	24	induce	induce	VB
cord-345472-qrddwebe	320	25	innate	innate	JJ
cord-345472-qrddwebe	320	26	IL-17	IL-17	NNP
cord-345472-qrddwebe	320	27	production	production	NN
cord-345472-qrddwebe	320	28	from	from	IN
cord-345472-qrddwebe	320	29	gammadelta	gammadelta	NNP
cord-345472-qrddwebe	320	30	T	T	NNP
cord-345472-qrddwebe	320	31	cells	cell	NNS
cord-345472-qrddwebe	320	32	,	,	,
cord-345472-qrddwebe	320	33	amplifying	amplify	VBG
cord-345472-qrddwebe	320	34	Th17	th17	CD
cord-345472-qrddwebe	321	1	responses	response	NNS
cord-345472-qrddwebe	321	2	and	and	CC
cord-345472-qrddwebe	321	3	autoimmunity	autoimmunity	IN
cord-345472-qrddwebe	321	4	Hmgb1-IL-23-IL-17-IL-6-Stat3	Hmgb1-IL-23-IL-17-IL-6-Stat3	NNP
cord-345472-qrddwebe	321	5	axis	axis	NN
cord-345472-qrddwebe	321	6	promotes	promote	VBZ
cord-345472-qrddwebe	321	7	tumor	tumor	NN
cord-345472-qrddwebe	321	8	growth	growth	NN
cord-345472-qrddwebe	321	9	in	in	IN
cord-345472-qrddwebe	321	10	murine	murine	JJ
cord-345472-qrddwebe	321	11	models	model	NNS
cord-345472-qrddwebe	321	12	of	of	IN
cord-345472-qrddwebe	321	13	melanoma	melanoma	NN
cord-345472-qrddwebe	321	14	S100A9	S100A9	NNP
cord-345472-qrddwebe	321	15	gene	gene	NN
cord-345472-qrddwebe	321	16	silencing	silencing	NN
cord-345472-qrddwebe	321	17	inhibits	inhibit	VBZ
cord-345472-qrddwebe	321	18	the	the	DT
cord-345472-qrddwebe	321	19	release	release	NN
cord-345472-qrddwebe	321	20	of	of	IN
cord-345472-qrddwebe	321	21	pro	pro	JJ
cord-345472-qrddwebe	321	22	-	-	JJ
cord-345472-qrddwebe	321	23	inflammatory	inflammatory	JJ
cord-345472-qrddwebe	321	24	cytokines	cytokine	NNS
cord-345472-qrddwebe	321	25	by	by	IN
cord-345472-qrddwebe	321	26	blocking	block	VBG
cord-345472-qrddwebe	321	27	the	the	DT
cord-345472-qrddwebe	321	28	IL-17	IL-17	NNP
cord-345472-qrddwebe	321	29	signalling	signal	VBG
cord-345472-qrddwebe	321	30	pathway	pathway	NN
cord-345472-qrddwebe	321	31	in	in	IN
cord-345472-qrddwebe	321	32	mice	mouse	NNS
cord-345472-qrddwebe	321	33	with	with	IN
cord-345472-qrddwebe	321	34	acute	acute	JJ
cord-345472-qrddwebe	321	35	pancreatitis	pancreatitis	NN
cord-345472-qrddwebe	322	1	IL-17-induced	il-17-induce	VBN
cord-345472-qrddwebe	322	2	pulmonary	pulmonary	JJ
cord-345472-qrddwebe	322	3	pathogenesis	pathogenesis	NN
cord-345472-qrddwebe	322	4	during	during	IN
cord-345472-qrddwebe	322	5	respiratory	respiratory	JJ
cord-345472-qrddwebe	322	6	viral	viral	JJ
cord-345472-qrddwebe	322	7	infection	infection	NN
cord-345472-qrddwebe	322	8	and	and	CC
cord-345472-qrddwebe	322	9	exacerbation	exacerbation	NN
cord-345472-qrddwebe	322	10	of	of	IN
cord-345472-qrddwebe	322	11	allergic	allergic	JJ
cord-345472-qrddwebe	322	12	disease	disease	NN
cord-345472-qrddwebe	323	1	Local	local	JJ
cord-345472-qrddwebe	323	2	IL-17A	IL-17A	NNP
cord-345472-qrddwebe	323	3	potentiates	potentiate	VBZ
cord-345472-qrddwebe	323	4	early	early	JJ
cord-345472-qrddwebe	323	5	neutrophil	neutrophil	NN
cord-345472-qrddwebe	323	6	recruitment	recruitment	NN
cord-345472-qrddwebe	323	7	to	to	IN
cord-345472-qrddwebe	323	8	the	the	DT
cord-345472-qrddwebe	323	9	respiratory	respiratory	JJ
cord-345472-qrddwebe	323	10	tract	tract	NN
cord-345472-qrddwebe	323	11	during	during	IN
cord-345472-qrddwebe	323	12	severe	severe	JJ
cord-345472-qrddwebe	323	13	RSV	RSV	NNP
cord-345472-qrddwebe	323	14	infection	infection	NN
cord-345472-qrddwebe	323	15	Neutrophils	Neutrophils	NNP
cord-345472-qrddwebe	323	16	in	in	IN
cord-345472-qrddwebe	323	17	respiratory	respiratory	JJ
cord-345472-qrddwebe	323	18	syncytial	syncytial	JJ
cord-345472-qrddwebe	323	19	virus	virus	NN
cord-345472-qrddwebe	323	20	infection	infection	NN
cord-345472-qrddwebe	323	21	:	:	:
cord-345472-qrddwebe	323	22	A	a	DT
cord-345472-qrddwebe	323	23	target	target	NN
cord-345472-qrddwebe	323	24	for	for	IN
cord-345472-qrddwebe	323	25	asthma	asthma	NN
cord-345472-qrddwebe	323	26	prevention	prevention	NN
cord-345472-qrddwebe	324	1	Interleukin-1	Interleukin-1	NNP
cord-345472-qrddwebe	324	2	alpha	alpha	NN
cord-345472-qrddwebe	324	3	mediates	mediate	VBZ
cord-345472-qrddwebe	324	4	the	the	DT
cord-345472-qrddwebe	324	5	enhanced	enhanced	JJ
cord-345472-qrddwebe	324	6	expression	expression	NN
cord-345472-qrddwebe	324	7	of	of	IN
cord-345472-qrddwebe	324	8	intercellular	intercellular	JJ
cord-345472-qrddwebe	324	9	adhesion	adhesion	NN
cord-345472-qrddwebe	324	10	molecule-1	molecule-1	NN
cord-345472-qrddwebe	324	11	in	in	IN
cord-345472-qrddwebe	324	12	pulmonary	pulmonary	JJ
cord-345472-qrddwebe	324	13	epithelial	epithelial	JJ
cord-345472-qrddwebe	324	14	cells	cell	NNS
cord-345472-qrddwebe	324	15	infected	infect	VBN
cord-345472-qrddwebe	324	16	with	with	IN
cord-345472-qrddwebe	324	17	respiratory	respiratory	JJ
cord-345472-qrddwebe	324	18	syncytial	syncytial	JJ
cord-345472-qrddwebe	324	19	virus	virus	NN
cord-345472-qrddwebe	324	20	Primary	primary	JJ
cord-345472-qrddwebe	324	21	infection	infection	NN
cord-345472-qrddwebe	324	22	of	of	IN
cord-345472-qrddwebe	324	23	mice	mouse	NNS
cord-345472-qrddwebe	324	24	with	with	IN
cord-345472-qrddwebe	324	25	high	high	JJ
cord-345472-qrddwebe	324	26	titer	titer	NN
cord-345472-qrddwebe	324	27	inoculum	inoculum	NN
cord-345472-qrddwebe	324	28	respiratory	respiratory	JJ
cord-345472-qrddwebe	324	29	syncytial	syncytial	JJ
cord-345472-qrddwebe	324	30	virus	virus	NN
cord-345472-qrddwebe	324	31	:	:	:
cord-345472-qrddwebe	325	1	Characterization	characterization	NN
cord-345472-qrddwebe	325	2	and	and	CC
cord-345472-qrddwebe	325	3	response	response	NN
cord-345472-qrddwebe	325	4	to	to	IN
cord-345472-qrddwebe	325	5	antiviral	antiviral	JJ
cord-345472-qrddwebe	325	6	therapy	therapy	NN
cord-345472-qrddwebe	325	7	.	.	.
cord-345472-qrddwebe	326	1	Can	Can	MD
cord-345472-qrddwebe	326	2	Reduced	reduce	VBN
cord-345472-qrddwebe	326	3	Nasal	nasal	NN
cord-345472-qrddwebe	326	4	Viral	Viral	NNP
cord-345472-qrddwebe	326	5	Load	Load	NNP
cord-345472-qrddwebe	326	6	and	and	CC
cord-345472-qrddwebe	326	7	IFN	IFN	NNP
cord-345472-qrddwebe	326	8	Responses	response	NNS
cord-345472-qrddwebe	326	9	in	in	IN
cord-345472-qrddwebe	326	10	Infants	infant	NNS
cord-345472-qrddwebe	326	11	with	with	IN
cord-345472-qrddwebe	326	12	Respiratory	respiratory	JJ
cord-345472-qrddwebe	326	13	Syncytial	Syncytial	NNP
cord-345472-qrddwebe	326	14	Virus	virus	NN
cord-345472-qrddwebe	326	15	Bronchiolitis	Bronchiolitis	NNP
cord-345472-qrddwebe	326	16	and	and	CC
cord-345472-qrddwebe	326	17	Respiratory	respiratory	JJ
cord-345472-qrddwebe	326	18	Failure	failure	NN
cord-345472-qrddwebe	327	1	RSV	RSV	NNP
cord-345472-qrddwebe	327	2	vaccine	vaccine	NN
cord-345472-qrddwebe	327	3	-	-	HYPH
cord-345472-qrddwebe	327	4	enhanced	enhance	VBN
cord-345472-qrddwebe	327	5	disease	disease	NN
cord-345472-qrddwebe	327	6	is	be	VBZ
cord-345472-qrddwebe	327	7	orchestrated	orchestrate	VBN
cord-345472-qrddwebe	327	8	by	by	IN
cord-345472-qrddwebe	327	9	the	the	DT
cord-345472-qrddwebe	327	10	combined	combined	JJ
cord-345472-qrddwebe	327	11	actions	action	NNS
cord-345472-qrddwebe	327	12	of	of	IN
cord-345472-qrddwebe	327	13	distinct	distinct	JJ
cord-345472-qrddwebe	327	14	CD4	CD4	NNP
cord-345472-qrddwebe	327	15	T	T	NNP
cord-345472-qrddwebe	327	16	cell	cell	NN
cord-345472-qrddwebe	327	17	subsets	subset	NNS
cord-345472-qrddwebe	328	1	Human	human	JJ
cord-345472-qrddwebe	328	2	neutrophil	neutrophil	NN
cord-345472-qrddwebe	328	3	elastase	elastase	NN
cord-345472-qrddwebe	328	4	in	in	IN
cord-345472-qrddwebe	328	5	RSV	RSV	NNP
cord-345472-qrddwebe	328	6	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	328	7	Matrix	Matrix	NNP
cord-345472-qrddwebe	328	8	metalloprotease	metalloprotease	NNP
cord-345472-qrddwebe	328	9	9	9	CD
cord-345472-qrddwebe	328	10	mediates	mediate	VBZ
cord-345472-qrddwebe	328	11	neutrophil	neutrophil	NN
cord-345472-qrddwebe	328	12	migration	migration	NN
cord-345472-qrddwebe	328	13	into	into	IN
cord-345472-qrddwebe	328	14	the	the	DT
cord-345472-qrddwebe	328	15	airways	airways	NNPS
cord-345472-qrddwebe	328	16	in	in	IN
cord-345472-qrddwebe	328	17	response	response	NN
cord-345472-qrddwebe	328	18	to	to	IN
cord-345472-qrddwebe	328	19	influenza	influenza	NN
cord-345472-qrddwebe	328	20	virus	virus	NN
cord-345472-qrddwebe	328	21	-	-	HYPH
cord-345472-qrddwebe	328	22	induced	induce	VBN
cord-345472-qrddwebe	328	23	toll	toll	NN
cord-345472-qrddwebe	328	24	-	-	HYPH
cord-345472-qrddwebe	328	25	like	like	JJ
cord-345472-qrddwebe	328	26	receptor	receptor	NN
cord-345472-qrddwebe	328	27	signaling	signal	VBG
cord-345472-qrddwebe	328	28	Respiratory	respiratory	JJ
cord-345472-qrddwebe	328	29	syncytial	syncytial	JJ
cord-345472-qrddwebe	328	30	virus	virus	NN
cord-345472-qrddwebe	328	31	induces	induce	VBZ
cord-345472-qrddwebe	328	32	oxidative	oxidative	JJ
cord-345472-qrddwebe	328	33	stress	stress	NN
cord-345472-qrddwebe	328	34	by	by	IN
cord-345472-qrddwebe	328	35	modulating	modulate	VBG
cord-345472-qrddwebe	328	36	antioxidant	antioxidant	JJ
cord-345472-qrddwebe	328	37	enzymes	enzyme	NNS
cord-345472-qrddwebe	328	38	Respiratory	respiratory	JJ
cord-345472-qrddwebe	328	39	Syncytial	Syncytial	NNP
cord-345472-qrddwebe	328	40	Virus	Virus	NNP
cord-345472-qrddwebe	328	41	and	and	CC
cord-345472-qrddwebe	328	42	Cellular	Cellular	NNP
cord-345472-qrddwebe	328	43	Stress	Stress	NNP
cord-345472-qrddwebe	328	44	Responses	response	NNS
cord-345472-qrddwebe	328	45	:	:	:
cord-345472-qrddwebe	329	1	Impact	impact	NN
cord-345472-qrddwebe	329	2	on	on	IN
cord-345472-qrddwebe	329	3	Replication	Replication	NNP
cord-345472-qrddwebe	329	4	and	and	CC
cord-345472-qrddwebe	329	5	Physiopathology	Physiopathology	NNP
cord-345472-qrddwebe	329	6	Baicalein	Baicalein	NNP
cord-345472-qrddwebe	329	7	triazole	triazole	NN
cord-345472-qrddwebe	329	8	prevents	prevent	VBZ
cord-345472-qrddwebe	329	9	respiratory	respiratory	JJ
cord-345472-qrddwebe	329	10	tract	tract	NN
cord-345472-qrddwebe	329	11	infection	infection	NN
cord-345472-qrddwebe	329	12	by	by	IN
cord-345472-qrddwebe	329	13	RSV	RSV	NNP
cord-345472-qrddwebe	329	14	through	through	IN
cord-345472-qrddwebe	329	15	suppression	suppression	NN
cord-345472-qrddwebe	329	16	of	of	IN
cord-345472-qrddwebe	329	17	oxidative	oxidative	JJ
cord-345472-qrddwebe	329	18	damage	damage	NN
cord-345472-qrddwebe	330	1	Neutrophil	Neutrophil	NNP
cord-345472-qrddwebe	330	2	extracellular	extracellular	JJ
cord-345472-qrddwebe	330	3	traps	trap	NNS
cord-345472-qrddwebe	330	4	cause	cause	VBP
cord-345472-qrddwebe	330	5	airway	airway	JJ
cord-345472-qrddwebe	330	6	obstruction	obstruction	NN
cord-345472-qrddwebe	330	7	during	during	IN
cord-345472-qrddwebe	330	8	respiratory	respiratory	JJ
cord-345472-qrddwebe	330	9	syncytial	syncytial	JJ
cord-345472-qrddwebe	330	10	virus	virus	NN
cord-345472-qrddwebe	330	11	disease	disease	NN
cord-345472-qrddwebe	330	12	Neutrophil	Neutrophil	NNP
cord-345472-qrddwebe	330	13	heterogeneity	heterogeneity	NN
cord-345472-qrddwebe	330	14	in	in	IN
cord-345472-qrddwebe	330	15	health	health	NN
cord-345472-qrddwebe	330	16	and	and	CC
cord-345472-qrddwebe	330	17	disease	disease	NN
cord-345472-qrddwebe	330	18	:	:	:
cord-345472-qrddwebe	331	1	A	a	DT
cord-345472-qrddwebe	331	2	revitalized	revitalize	VBN
cord-345472-qrddwebe	331	3	avenue	avenue	NN
cord-345472-qrddwebe	331	4	in	in	IN
cord-345472-qrddwebe	331	5	inflammation	inflammation	NN
cord-345472-qrddwebe	331	6	and	and	CC
cord-345472-qrddwebe	331	7	immunity	immunity	NN
cord-345472-qrddwebe	331	8	Human	human	JJ
cord-345472-qrddwebe	331	9	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	331	10	in	in	IN
cord-345472-qrddwebe	331	11	the	the	DT
cord-345472-qrddwebe	331	12	saga	saga	NN
cord-345472-qrddwebe	331	13	of	of	IN
cord-345472-qrddwebe	331	14	cellular	cellular	JJ
cord-345472-qrddwebe	331	15	heterogeneity	heterogeneity	NN
cord-345472-qrddwebe	331	16	:	:	:
cord-345472-qrddwebe	331	17	Insights	insight	NNS
cord-345472-qrddwebe	331	18	and	and	CC
cord-345472-qrddwebe	331	19	open	open	JJ
cord-345472-qrddwebe	331	20	questions	question	NNS
cord-345472-qrddwebe	331	21	Developmental	Developmental	NNP
cord-345472-qrddwebe	331	22	Analysis	Analysis	NNP
cord-345472-qrddwebe	331	23	of	of	IN
cord-345472-qrddwebe	331	24	Bone	Bone	NNP
cord-345472-qrddwebe	331	25	Marrow	Marrow	NNP
cord-345472-qrddwebe	331	26	Neutrophils	Neutrophils	NNP
cord-345472-qrddwebe	331	27	Reveals	reveal	VBZ
cord-345472-qrddwebe	331	28	Populations	Populations	NNPS
cord-345472-qrddwebe	331	29	Specialized	Specialized	NNP
cord-345472-qrddwebe	331	30	in	in	IN
cord-345472-qrddwebe	331	31	Expansion	Expansion	NNP
cord-345472-qrddwebe	331	32	,	,	,
cord-345472-qrddwebe	331	33	Trafficking	trafficking	NN
cord-345472-qrddwebe	331	34	,	,	,
cord-345472-qrddwebe	331	35	and	and	CC
cord-345472-qrddwebe	331	36	Effector	Effector	NNP
cord-345472-qrddwebe	331	37	Functions	Functions	NNPS
cord-345472-qrddwebe	331	38	Neutrophil	Neutrophil	NNP
cord-345472-qrddwebe	332	1	subset	subset	JJ
cord-345472-qrddwebe	332	2	responses	response	NNS
cord-345472-qrddwebe	332	3	in	in	IN
cord-345472-qrddwebe	332	4	infants	infant	NNS
cord-345472-qrddwebe	332	5	with	with	IN
cord-345472-qrddwebe	332	6	severe	severe	JJ
cord-345472-qrddwebe	332	7	viral	viral	JJ
cord-345472-qrddwebe	332	8	respiratory	respiratory	JJ
cord-345472-qrddwebe	332	9	infection	infection	NN
cord-345472-qrddwebe	332	10	Shedding	shedding	NN
cord-345472-qrddwebe	332	11	of	of	IN
cord-345472-qrddwebe	332	12	L	l	NN
cord-345472-qrddwebe	332	13	-	-	HYPH
cord-345472-qrddwebe	332	14	selectin	selectin	NNP
cord-345472-qrddwebe	332	15	and	and	CC
cord-345472-qrddwebe	332	16	PECAM-1	PECAM-1	NNP
cord-345472-qrddwebe	332	17	and	and	CC
cord-345472-qrddwebe	332	18	upregulation	upregulation	NN
cord-345472-qrddwebe	332	19	of	of	IN
cord-345472-qrddwebe	332	20	Mac-1	Mac-1	NNP
cord-345472-qrddwebe	332	21	and	and	CC
cord-345472-qrddwebe	332	22	ICAM-1	ICAM-1	NNP
cord-345472-qrddwebe	332	23	on	on	IN
cord-345472-qrddwebe	332	24	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	332	25	in	in	IN
cord-345472-qrddwebe	332	26	RSV	RSV	NNP
cord-345472-qrddwebe	332	27	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	332	28	LAIR-1	lair-1	NN
cord-345472-qrddwebe	332	29	limits	limit	VBZ
cord-345472-qrddwebe	332	30	neutrophil	neutrophil	NN
cord-345472-qrddwebe	332	31	extracellular	extracellular	JJ
cord-345472-qrddwebe	332	32	trap	trap	NN
cord-345472-qrddwebe	332	33	formation	formation	NN
cord-345472-qrddwebe	332	34	in	in	IN
cord-345472-qrddwebe	332	35	viral	viral	JJ
cord-345472-qrddwebe	332	36	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	332	37	Respiratory	respiratory	JJ
cord-345472-qrddwebe	332	38	syncytial	syncytial	JJ
cord-345472-qrddwebe	332	39	virus	virus	NN
cord-345472-qrddwebe	332	40	infection	infection	NN
cord-345472-qrddwebe	332	41	enhances	enhance	VBZ
cord-345472-qrddwebe	332	42	neutrophil	neutrophil	NN
cord-345472-qrddwebe	332	43	and	and	CC
cord-345472-qrddwebe	332	44	eosinophil	eosinophil	JJ
cord-345472-qrddwebe	332	45	adhesion	adhesion	NN
cord-345472-qrddwebe	332	46	to	to	IN
cord-345472-qrddwebe	332	47	cultured	cultured	JJ
cord-345472-qrddwebe	332	48	respiratory	respiratory	JJ
cord-345472-qrddwebe	332	49	epithelial	epithelial	JJ
cord-345472-qrddwebe	332	50	cells	cell	NNS
cord-345472-qrddwebe	332	51	.	.	.
cord-345472-qrddwebe	333	1	Roles	role	NNS
cord-345472-qrddwebe	333	2	of	of	IN
cord-345472-qrddwebe	333	3	CD18	CD18	NNP
cord-345472-qrddwebe	333	4	and	and	CC
cord-345472-qrddwebe	333	5	intercellular	intercellular	JJ
cord-345472-qrddwebe	333	6	adhesion	adhesion	NN
cord-345472-qrddwebe	333	7	molecule-1	molecule-1	NNP
cord-345472-qrddwebe	333	8	Immune	Immune	NNP
cord-345472-qrddwebe	333	9	profiles	profile	NNS
cord-345472-qrddwebe	333	10	provide	provide	VBP
cord-345472-qrddwebe	333	11	insights	insight	NNS
cord-345472-qrddwebe	333	12	into	into	IN
cord-345472-qrddwebe	333	13	respiratory	respiratory	JJ
cord-345472-qrddwebe	333	14	syncytial	syncytial	JJ
cord-345472-qrddwebe	333	15	virus	virus	NN
cord-345472-qrddwebe	333	16	disease	disease	NN
cord-345472-qrddwebe	333	17	severity	severity	NN
cord-345472-qrddwebe	333	18	in	in	IN
cord-345472-qrddwebe	333	19	young	young	JJ
cord-345472-qrddwebe	333	20	children	child	NNS
cord-345472-qrddwebe	334	1	Respiratory	respiratory	JJ
cord-345472-qrddwebe	334	2	syncytial	syncytial	JJ
cord-345472-qrddwebe	334	3	virus	virus	NN
cord-345472-qrddwebe	334	4	fusion	fusion	NN
cord-345472-qrddwebe	334	5	protein	protein	NN
cord-345472-qrddwebe	334	6	promotes	promote	VBZ
cord-345472-qrddwebe	334	7	TLR-4-dependent	tlr-4-dependent	IN
cord-345472-qrddwebe	334	8	neutrophil	neutrophil	NN
cord-345472-qrddwebe	334	9	extracellular	extracellular	JJ
cord-345472-qrddwebe	334	10	trap	trap	NN
cord-345472-qrddwebe	334	11	formation	formation	NN
cord-345472-qrddwebe	334	12	by	by	IN
cord-345472-qrddwebe	334	13	human	human	JJ
cord-345472-qrddwebe	334	14	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	334	15	Neutrophil	Neutrophil	NNP
cord-345472-qrddwebe	334	16	TLR4	TLR4	NNP
cord-345472-qrddwebe	334	17	expression	expression	NN
cord-345472-qrddwebe	334	18	is	be	VBZ
cord-345472-qrddwebe	334	19	reduced	reduce	VBN
cord-345472-qrddwebe	334	20	in	in	IN
cord-345472-qrddwebe	334	21	the	the	DT
cord-345472-qrddwebe	334	22	airways	airway	NNS
cord-345472-qrddwebe	334	23	of	of	IN
cord-345472-qrddwebe	334	24	infants	infant	NNS
cord-345472-qrddwebe	334	25	with	with	IN
cord-345472-qrddwebe	334	26	severe	severe	JJ
cord-345472-qrddwebe	334	27	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	334	28	Association	Association	NNP
cord-345472-qrddwebe	334	29	between	between	IN
cord-345472-qrddwebe	334	30	common	common	JJ
cord-345472-qrddwebe	334	31	Toll	Toll	NNP
cord-345472-qrddwebe	334	32	-	-	HYPH
cord-345472-qrddwebe	334	33	like	like	JJ
cord-345472-qrddwebe	334	34	receptor	receptor	NN
cord-345472-qrddwebe	334	35	4	4	CD
cord-345472-qrddwebe	334	36	mutations	mutation	NNS
cord-345472-qrddwebe	334	37	and	and	CC
cord-345472-qrddwebe	334	38	severe	severe	JJ
cord-345472-qrddwebe	334	39	respiratory	respiratory	JJ
cord-345472-qrddwebe	334	40	syncytial	syncytial	JJ
cord-345472-qrddwebe	334	41	virus	virus	NN
cord-345472-qrddwebe	334	42	disease	disease	NN
cord-345472-qrddwebe	335	1	The	the	DT
cord-345472-qrddwebe	335	2	TLR4	TLR4	NNP
cord-345472-qrddwebe	335	3	antagonist	antagonist	NN
cord-345472-qrddwebe	335	4	Eritoran	Eritoran	NNP
cord-345472-qrddwebe	335	5	protects	protect	VBZ
cord-345472-qrddwebe	335	6	mice	mouse	NNS
cord-345472-qrddwebe	335	7	from	from	IN
cord-345472-qrddwebe	335	8	lethal	lethal	JJ
cord-345472-qrddwebe	335	9	influenza	influenza	NN
cord-345472-qrddwebe	335	10	infection	infection	NN
cord-345472-qrddwebe	335	11	Serum	Serum	NNP
cord-345472-qrddwebe	335	12	LL-37	LL-37	NNP
cord-345472-qrddwebe	335	13	Levels	level	NNS
cord-345472-qrddwebe	336	1	Associated	associate	VBN
cord-345472-qrddwebe	336	2	With	with	IN
cord-345472-qrddwebe	336	3	Severity	severity	NN
cord-345472-qrddwebe	336	4	of	of	IN
cord-345472-qrddwebe	336	5	Bronchiolitis	Bronchiolitis	NNP
cord-345472-qrddwebe	336	6	and	and	CC
cord-345472-qrddwebe	336	7	Viral	Viral	NNP
cord-345472-qrddwebe	336	8	Etiology	etiology	NN
cord-345472-qrddwebe	337	1	The	the	DT
cord-345472-qrddwebe	337	2	human	human	NN
cord-345472-qrddwebe	337	3	cathelicidin	cathelicidin	NN
cord-345472-qrddwebe	337	4	LL-37	LL-37	NNP
cord-345472-qrddwebe	337	5	has	have	VBZ
cord-345472-qrddwebe	337	6	antiviral	antiviral	JJ
cord-345472-qrddwebe	337	7	activity	activity	NN
cord-345472-qrddwebe	337	8	against	against	IN
cord-345472-qrddwebe	337	9	respiratory	respiratory	JJ
cord-345472-qrddwebe	337	10	syncytial	syncytial	JJ
cord-345472-qrddwebe	337	11	virus	virus	NN
cord-345472-qrddwebe	337	12	Human	human	JJ
cord-345472-qrddwebe	337	13	cathelicidin	cathelicidin	NNS
cord-345472-qrddwebe	337	14	,	,	,
cord-345472-qrddwebe	337	15	LL-37	LL-37	NNP
cord-345472-qrddwebe	337	16	,	,	,
cord-345472-qrddwebe	337	17	inhibits	inhibit	VBZ
cord-345472-qrddwebe	338	1	respiratory	respiratory	JJ
cord-345472-qrddwebe	338	2	syncytial	syncytial	JJ
cord-345472-qrddwebe	338	3	virus	virus	NN
cord-345472-qrddwebe	338	4	infection	infection	NN
cord-345472-qrddwebe	338	5	in	in	IN
cord-345472-qrddwebe	338	6	polarized	polarized	JJ
cord-345472-qrddwebe	338	7	airway	airway	NN
cord-345472-qrddwebe	338	8	epithelial	epithelial	NN
cord-345472-qrddwebe	338	9	cells	cell	NNS
cord-345472-qrddwebe	338	10	Cathelicidins	cathelicidin	NNS
cord-345472-qrddwebe	338	11	Have	have	VBP
cord-345472-qrddwebe	338	12	Direct	direct	JJ
cord-345472-qrddwebe	338	13	Antiviral	antiviral	JJ
cord-345472-qrddwebe	338	14	Activity	activity	NN
cord-345472-qrddwebe	338	15	against	against	IN
cord-345472-qrddwebe	338	16	Respiratory	respiratory	JJ
cord-345472-qrddwebe	338	17	Syncytial	Syncytial	NNP
cord-345472-qrddwebe	338	18	Virus	virus	NN
cord-345472-qrddwebe	339	1	In	in	IN
cord-345472-qrddwebe	339	2	Vitro	Vitro	NNP
cord-345472-qrddwebe	339	3	and	and	CC
cord-345472-qrddwebe	339	4	Protective	Protective	NNP
cord-345472-qrddwebe	339	5	Function	Function	NNP
cord-345472-qrddwebe	339	6	In	in	IN
cord-345472-qrddwebe	339	7	Vivo	Vivo	NNP
cord-345472-qrddwebe	339	8	in	in	IN
cord-345472-qrddwebe	339	9	Mice	Mice	NNP
cord-345472-qrddwebe	339	10	and	and	CC
cord-345472-qrddwebe	339	11	Humans	Humans	NNPS
cord-345472-qrddwebe	339	12	T	T	NNP
cord-345472-qrddwebe	339	13	-	-	HYPH
cord-345472-qrddwebe	339	14	cell	cell	NN
cord-345472-qrddwebe	339	15	activation	activation	NN
cord-345472-qrddwebe	339	16	during	during	IN
cord-345472-qrddwebe	339	17	natural	natural	JJ
cord-345472-qrddwebe	339	18	respiratory	respiratory	JJ
cord-345472-qrddwebe	339	19	syncytial	syncytial	JJ
cord-345472-qrddwebe	339	20	virus	virus	NN
cord-345472-qrddwebe	339	21	infection	infection	NN
cord-345472-qrddwebe	339	22	in	in	IN
cord-345472-qrddwebe	339	23	infants	infant	NNS
cord-345472-qrddwebe	340	1	Neutrophil	Neutrophil	NNP
cord-345472-qrddwebe	340	2	-	-	HYPH
cord-345472-qrddwebe	340	3	mediated	mediate	VBN
cord-345472-qrddwebe	340	4	inflammation	inflammation	NN
cord-345472-qrddwebe	340	5	in	in	IN
cord-345472-qrddwebe	340	6	respiratory	respiratory	JJ
cord-345472-qrddwebe	340	7	syncytial	syncytial	JJ
cord-345472-qrddwebe	340	8	viral	viral	JJ
cord-345472-qrddwebe	340	9	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	340	10	Respiratory	Respiratory	NNP
cord-345472-qrddwebe	340	11	Syncytial	Syncytial	NNP
cord-345472-qrddwebe	340	12	Virus	Virus	NNP
cord-345472-qrddwebe	340	13	induces	induce	VBZ
cord-345472-qrddwebe	340	14	the	the	DT
cord-345472-qrddwebe	340	15	classical	classical	JJ
cord-345472-qrddwebe	340	16	ROS	ROS	NNP
cord-345472-qrddwebe	340	17	-	-	HYPH
cord-345472-qrddwebe	340	18	dependent	dependent	JJ
cord-345472-qrddwebe	340	19	NETosis	netosis	NN
cord-345472-qrddwebe	340	20	through	through	IN
cord-345472-qrddwebe	340	21	PAD-4	PAD-4	NNP
cord-345472-qrddwebe	340	22	and	and	CC
cord-345472-qrddwebe	340	23	necroptosis	necroptosis	NNP
cord-345472-qrddwebe	340	24	pathways	pathway	NNS
cord-345472-qrddwebe	340	25	activation	activation	NN
cord-345472-qrddwebe	341	1	Neutrophil	Neutrophil	NNP
cord-345472-qrddwebe	341	2	Extracellular	Extracellular	NNP
cord-345472-qrddwebe	341	3	Traps	Traps	NNPS
cord-345472-qrddwebe	341	4	in	in	IN
cord-345472-qrddwebe	341	5	Respiratory	respiratory	JJ
cord-345472-qrddwebe	341	6	Disease	Disease	NNP
cord-345472-qrddwebe	341	7	:	:	:
cord-345472-qrddwebe	341	8	Guided	Guided	NNP
cord-345472-qrddwebe	341	9	anti	anti	JJ
cord-345472-qrddwebe	341	10	-	-	JJ
cord-345472-qrddwebe	341	11	microbial	microbial	JJ
cord-345472-qrddwebe	341	12	traps	trap	NNS
cord-345472-qrddwebe	341	13	or	or	CC
cord-345472-qrddwebe	341	14	toxic	toxic	JJ
cord-345472-qrddwebe	341	15	webs	web	NNS
cord-345472-qrddwebe	341	16	?	?	.
cord-345472-qrddwebe	342	1	Pulmonary	pulmonary	JJ
cord-345472-qrddwebe	342	2	matrix	matrix	NN
cord-345472-qrddwebe	342	3	metalloproteinase-9	metalloproteinase-9	NNP
cord-345472-qrddwebe	342	4	activity	activity	NN
cord-345472-qrddwebe	342	5	in	in	IN
cord-345472-qrddwebe	342	6	mechanically	mechanically	RB
cord-345472-qrddwebe	342	7	ventilated	ventilate	VBN
cord-345472-qrddwebe	342	8	children	child	NNS
cord-345472-qrddwebe	342	9	with	with	IN
cord-345472-qrddwebe	343	1	respiratory	respiratory	JJ
cord-345472-qrddwebe	343	2	syncytial	syncytial	JJ
cord-345472-qrddwebe	343	3	virus	virus	NN
cord-345472-qrddwebe	343	4	Matrix	Matrix	NNP
cord-345472-qrddwebe	343	5	Metalloproteinase-9	Metalloproteinase-9	NNP
cord-345472-qrddwebe	343	6	Mediates	mediate	VBZ
cord-345472-qrddwebe	343	7	RSV	RSV	NNP
cord-345472-qrddwebe	343	8	Infection	infection	NN
cord-345472-qrddwebe	343	9	in	in	IN
cord-345472-qrddwebe	343	10	Vitro	Vitro	NNP
cord-345472-qrddwebe	343	11	and	and	CC
cord-345472-qrddwebe	343	12	in	in	IN
cord-345472-qrddwebe	343	13	Vivo	Vivo	NNP
cord-345472-qrddwebe	343	14	Early	early	JJ
cord-345472-qrddwebe	343	15	elevation	elevation	NN
cord-345472-qrddwebe	343	16	of	of	IN
cord-345472-qrddwebe	343	17	matrix	matrix	NN
cord-345472-qrddwebe	343	18	metalloproteinase-8	metalloproteinase-8	NNP
cord-345472-qrddwebe	343	19	and	and	CC
cord-345472-qrddwebe	344	1	-9	-9	NNP
cord-345472-qrddwebe	345	1	in	in	IN
cord-345472-qrddwebe	345	2	pediatric	pediatric	JJ
cord-345472-qrddwebe	345	3	ARDS	ARDS	NNP
cord-345472-qrddwebe	345	4	is	be	VBZ
cord-345472-qrddwebe	345	5	associated	associate	VBN
cord-345472-qrddwebe	345	6	with	with	IN
cord-345472-qrddwebe	345	7	an	an	DT
cord-345472-qrddwebe	345	8	increased	increase	VBN
cord-345472-qrddwebe	345	9	risk	risk	NN
cord-345472-qrddwebe	345	10	of	of	IN
cord-345472-qrddwebe	345	11	prolonged	prolong	VBN
cord-345472-qrddwebe	345	12	mechanical	mechanical	JJ
cord-345472-qrddwebe	345	13	ventilation	ventilation	NN
cord-345472-qrddwebe	346	1	Azithromycin	Azithromycin	NNP
cord-345472-qrddwebe	346	2	attenuates	attenuate	VBZ
cord-345472-qrddwebe	346	3	airway	airway	JJ
cord-345472-qrddwebe	346	4	inflammation	inflammation	NN
cord-345472-qrddwebe	346	5	in	in	IN
cord-345472-qrddwebe	346	6	a	a	DT
cord-345472-qrddwebe	346	7	mouse	mouse	NN
cord-345472-qrddwebe	346	8	model	model	NN
cord-345472-qrddwebe	346	9	of	of	IN
cord-345472-qrddwebe	347	1	viral	viral	JJ
cord-345472-qrddwebe	347	2	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	347	3	Clarithromycin	Clarithromycin	NNP
cord-345472-qrddwebe	347	4	targets	target	VBZ
cord-345472-qrddwebe	347	5	neutrophilic	neutrophilic	NNP
cord-345472-qrddwebe	347	6	airway	airway	JJ
cord-345472-qrddwebe	347	7	inflammation	inflammation	NN
cord-345472-qrddwebe	347	8	in	in	IN
cord-345472-qrddwebe	347	9	refractory	refractory	JJ
cord-345472-qrddwebe	347	10	asthma	asthma	NN
cord-345472-qrddwebe	347	11	Azithromycin	Azithromycin	NNP
cord-345472-qrddwebe	347	12	therapy	therapy	NN
cord-345472-qrddwebe	347	13	during	during	IN
cord-345472-qrddwebe	347	14	respiratory	respiratory	JJ
cord-345472-qrddwebe	347	15	syncytial	syncytial	JJ
cord-345472-qrddwebe	347	16	virus	virus	NN
cord-345472-qrddwebe	347	17	bronchiolitis	bronchiolitis	NN
cord-345472-qrddwebe	347	18	:	:	:
cord-345472-qrddwebe	347	19	Upper	upper	JJ
cord-345472-qrddwebe	347	20	airway	airway	NN
cord-345472-qrddwebe	347	21	microbiome	microbiome	NN
cord-345472-qrddwebe	347	22	alterations	alteration	NNS
cord-345472-qrddwebe	347	23	and	and	CC
cord-345472-qrddwebe	347	24	subsequent	subsequent	JJ
cord-345472-qrddwebe	347	25	recurrent	recurrent	JJ
cord-345472-qrddwebe	347	26	wheeze	wheeze	NN
cord-345472-qrddwebe	348	1	Danirixin	Danirixin	NNP
cord-345472-qrddwebe	348	2	:	:	:
cord-345472-qrddwebe	349	1	A	a	DT
cord-345472-qrddwebe	349	2	Reversible	reversible	JJ
cord-345472-qrddwebe	349	3	and	and	CC
cord-345472-qrddwebe	349	4	Selective	selective	JJ
cord-345472-qrddwebe	349	5	Antagonist	antagonist	NN
cord-345472-qrddwebe	349	6	of	of	IN
cord-345472-qrddwebe	349	7	the	the	DT
cord-345472-qrddwebe	349	8	CXC	CXC	NNP
cord-345472-qrddwebe	349	9	Chemokine	Chemokine	NNP
cord-345472-qrddwebe	349	10	Receptor	Receptor	NNP
cord-345472-qrddwebe	349	11	2	2	CD
cord-345472-qrddwebe	350	1	The	the	DT
cord-345472-qrddwebe	350	2	effect	effect	NN
cord-345472-qrddwebe	350	3	of	of	IN
cord-345472-qrddwebe	350	4	marimastat	marimastat	NNP
cord-345472-qrddwebe	350	5	,	,	,
cord-345472-qrddwebe	350	6	a	a	DT
cord-345472-qrddwebe	350	7	metalloprotease	metalloprotease	NNP
cord-345472-qrddwebe	350	8	inhibitor	inhibitor	NN
cord-345472-qrddwebe	350	9	,	,	,
cord-345472-qrddwebe	350	10	on	on	IN
cord-345472-qrddwebe	350	11	allergen	allergen	NN
cord-345472-qrddwebe	350	12	-	-	HYPH
cord-345472-qrddwebe	350	13	induced	induce	VBN
cord-345472-qrddwebe	350	14	asthmatic	asthmatic	JJ
cord-345472-qrddwebe	350	15	hyper	hyper	JJ
cord-345472-qrddwebe	350	16	-	-	JJ
cord-345472-qrddwebe	350	17	reactivity	reactivity	JJ
cord-345472-qrddwebe	350	18	Inhibition	inhibition	NN
cord-345472-qrddwebe	350	19	of	of	IN
cord-345472-qrddwebe	350	20	matrix	matrix	NN
cord-345472-qrddwebe	350	21	metalloproteinases	metalloproteinase	NNS
cord-345472-qrddwebe	350	22	prevents	prevent	VBZ
cord-345472-qrddwebe	350	23	allergen	allergen	NN
cord-345472-qrddwebe	350	24	-	-	HYPH
cord-345472-qrddwebe	350	25	induced	induce	VBN
cord-345472-qrddwebe	350	26	airway	airway	JJ
cord-345472-qrddwebe	350	27	inflammation	inflammation	NN
cord-345472-qrddwebe	350	28	in	in	IN
cord-345472-qrddwebe	350	29	a	a	DT
cord-345472-qrddwebe	350	30	murine	murine	JJ
cord-345472-qrddwebe	350	31	model	model	NN
cord-345472-qrddwebe	350	32	of	of	IN
cord-345472-qrddwebe	350	33	asthma	asthma	NN
cord-345472-qrddwebe	350	34	Phase	Phase	NNP
cord-345472-qrddwebe	350	35	II	II	NNP
cord-345472-qrddwebe	350	36	study	study	NN
cord-345472-qrddwebe	350	37	of	of	IN
cord-345472-qrddwebe	350	38	a	a	DT
cord-345472-qrddwebe	350	39	neutrophil	neutrophil	NN
cord-345472-qrddwebe	350	40	elastase	elastase	NN
cord-345472-qrddwebe	350	41	inhibitor	inhibitor	NN
cord-345472-qrddwebe	350	42	(	(	-LRB-
cord-345472-qrddwebe	350	43	AZD9668	AZD9668	NNP
cord-345472-qrddwebe	350	44	)	)	-RRB-
cord-345472-qrddwebe	350	45	in	in	IN
cord-345472-qrddwebe	350	46	patients	patient	NNS
cord-345472-qrddwebe	350	47	with	with	IN
cord-345472-qrddwebe	350	48	bronchiectasis	bronchiectasis	NN
cord-345472-qrddwebe	350	49	PF-1355	PF-1355	NNP
cord-345472-qrddwebe	350	50	,	,	,
cord-345472-qrddwebe	350	51	a	a	DT
cord-345472-qrddwebe	350	52	mechanism	mechanism	NN
cord-345472-qrddwebe	350	53	-	-	HYPH
cord-345472-qrddwebe	350	54	based	base	VBN
cord-345472-qrddwebe	350	55	myeloperoxidase	myeloperoxidase	NN
cord-345472-qrddwebe	350	56	inhibitor	inhibitor	NN
cord-345472-qrddwebe	350	57	,	,	,
cord-345472-qrddwebe	350	58	prevents	prevent	VBZ
cord-345472-qrddwebe	350	59	immune	immune	JJ
cord-345472-qrddwebe	350	60	complex	complex	JJ
cord-345472-qrddwebe	350	61	vasculitis	vasculitis	NN
cord-345472-qrddwebe	350	62	and	and	CC
cord-345472-qrddwebe	350	63	anti	anti	JJ
cord-345472-qrddwebe	350	64	-	-	JJ
cord-345472-qrddwebe	350	65	glomerular	glomerular	JJ
cord-345472-qrddwebe	350	66	basement	basement	NN
cord-345472-qrddwebe	350	67	membrane	membrane	NN
cord-345472-qrddwebe	350	68	glomerulonephritis	glomerulonephritis	NN
cord-345472-qrddwebe	351	1	TAK-242	tak-242	DT
cord-345472-qrddwebe	351	2	,	,	,
cord-345472-qrddwebe	351	3	a	a	DT
cord-345472-qrddwebe	351	4	small	small	JJ
cord-345472-qrddwebe	351	5	-	-	HYPH
cord-345472-qrddwebe	351	6	molecule	molecule	NN
cord-345472-qrddwebe	351	7	inhibitor	inhibitor	NN
cord-345472-qrddwebe	351	8	of	of	IN
cord-345472-qrddwebe	351	9	Toll	Toll	NNP
cord-345472-qrddwebe	351	10	-	-	HYPH
cord-345472-qrddwebe	351	11	like	like	JJ
cord-345472-qrddwebe	351	12	receptor	receptor	NN
cord-345472-qrddwebe	351	13	4	4	CD
cord-345472-qrddwebe	351	14	signalling	signalling	NN
cord-345472-qrddwebe	351	15	,	,	,
cord-345472-qrddwebe	351	16	unveils	unveil	VBZ
cord-345472-qrddwebe	351	17	similarities	similarity	NNS
cord-345472-qrddwebe	351	18	and	and	CC
cord-345472-qrddwebe	351	19	differences	difference	NNS
cord-345472-qrddwebe	351	20	in	in	IN
cord-345472-qrddwebe	351	21	lipopolysaccharide	lipopolysaccharide	NN
cord-345472-qrddwebe	351	22	-	-	HYPH
cord-345472-qrddwebe	351	23	and	and	CC
cord-345472-qrddwebe	351	24	lipid	lipid	NN
cord-345472-qrddwebe	351	25	-	-	HYPH
cord-345472-qrddwebe	351	26	induced	induce	VBN
cord-345472-qrddwebe	351	27	inflammation	inflammation	NN
cord-345472-qrddwebe	351	28	and	and	CC
cord-345472-qrddwebe	351	29	insulin	insulin	NN
cord-345472-qrddwebe	351	30	resistance	resistance	NN
cord-345472-qrddwebe	351	31	in	in	IN
cord-345472-qrddwebe	351	32	muscle	muscle	NN
cord-345472-qrddwebe	351	33	cells	cell	NNS
cord-345472-qrddwebe	351	34	Neutrophil	Neutrophil	NNP
cord-345472-qrddwebe	351	35	-	-	HYPH
cord-345472-qrddwebe	351	36	mediated	mediate	VBN
cord-345472-qrddwebe	351	37	IFN	IFN	NNP
cord-345472-qrddwebe	351	38	activation	activation	NN
cord-345472-qrddwebe	351	39	in	in	IN
cord-345472-qrddwebe	351	40	the	the	DT
cord-345472-qrddwebe	351	41	bone	bone	NN
cord-345472-qrddwebe	351	42	marrow	marrow	NN
cord-345472-qrddwebe	351	43	alters	alter	VBZ
cord-345472-qrddwebe	351	44	B	b	NN
cord-345472-qrddwebe	351	45	cell	cell	NN
cord-345472-qrddwebe	351	46	development	development	NN
cord-345472-qrddwebe	351	47	in	in	IN
cord-345472-qrddwebe	352	1	human	human	JJ
cord-345472-qrddwebe	352	2	and	and	CC
cord-345472-qrddwebe	352	3	murine	murine	JJ
cord-345472-qrddwebe	352	4	systemic	systemic	JJ
cord-345472-qrddwebe	352	5	lupus	lupus	NN
cord-345472-qrddwebe	352	6	erythematosus	erythematosus	NN
cord-345472-qrddwebe	352	7	Locally	locally	RB
cord-345472-qrddwebe	352	8	instructed	instruct	VBD
cord-345472-qrddwebe	353	1	CXCR4(hi	CXCR4(hi	NNP
cord-345472-qrddwebe	353	2	)	)	-RRB-
cord-345472-qrddwebe	353	3	neutrophils	neutrophil	NNS
cord-345472-qrddwebe	353	4	trigger	trigger	VBP
cord-345472-qrddwebe	353	5	environment	environment	NN
cord-345472-qrddwebe	353	6	-	-	HYPH
cord-345472-qrddwebe	353	7	driven	drive	VBN
cord-345472-qrddwebe	353	8	allergic	allergic	JJ
cord-345472-qrddwebe	353	9	asthma	asthma	NN
cord-345472-qrddwebe	353	10	through	through	IN
cord-345472-qrddwebe	353	11	the	the	DT
cord-345472-qrddwebe	353	12	release	release	NN
cord-345472-qrddwebe	353	13	of	of	IN
cord-345472-qrddwebe	353	14	neutrophil	neutrophil	NN
cord-345472-qrddwebe	353	15	extracellular	extracellular	JJ
cord-345472-qrddwebe	353	16	traps	trap	NNS
cord-345472-qrddwebe	354	1	Simvastatin	Simvastatin	NNP
cord-345472-qrddwebe	354	2	Improves	improve	VBZ
cord-345472-qrddwebe	354	3	Neutrophil	Neutrophil	NNP
cord-345472-qrddwebe	354	4	Function	Function	NNP
cord-345472-qrddwebe	354	5	and	and	CC
cord-345472-qrddwebe	354	6	Clinical	Clinical	NNP
cord-345472-qrddwebe	354	7	Outcomes	Outcomes	NNPS
cord-345472-qrddwebe	354	8	in	in	IN
cord-345472-qrddwebe	354	9	Pneumonia	Pneumonia	NNP
cord-345472-qrddwebe	354	10	.	.	.
cord-345472-qrddwebe	355	1	A	a	DT
cord-345472-qrddwebe	355	2	Pilot	Pilot	NNP
cord-345472-qrddwebe	355	3	Randomized	Randomized	NNP
cord-345472-qrddwebe	355	4	Controlled	Controlled	NNP
cord-345472-qrddwebe	355	5	Clinical	Clinical	NNP
cord-345472-qrddwebe	355	6	Trial	Trial	NNP
cord-345472-qrddwebe	356	1	This	this	DT
cord-345472-qrddwebe	356	2	article	article	NN
cord-345472-qrddwebe	356	3	is	be	VBZ
cord-345472-qrddwebe	356	4	an	an	DT
cord-345472-qrddwebe	356	5	open	open	JJ
cord-345472-qrddwebe	356	6	access	access	NN
cord-345472-qrddwebe	356	7	article	article	NN
cord-345472-qrddwebe	356	8	distributed	distribute	VBN
cord-345472-qrddwebe	356	9	under	under	IN
cord-345472-qrddwebe	356	10	the	the	DT
cord-345472-qrddwebe	356	11	terms	term	NNS
cord-345472-qrddwebe	356	12	and	and	CC
cord-345472-qrddwebe	356	13	conditions	condition	NNS
cord-345472-qrddwebe	356	14	of	of	IN
cord-345472-qrddwebe	356	15	the	the	DT
cord-345472-qrddwebe	356	16	Creative	Creative	NNP
cord-345472-qrddwebe	356	17	Commons	Commons	NNP
cord-345472-qrddwebe	356	18	Attribution	Attribution	NNP
cord-345472-qrddwebe	356	19	(	(	-LRB-
cord-345472-qrddwebe	356	20	CC	CC	NNP
cord-345472-qrddwebe	356	21	BY	by	IN
cord-345472-qrddwebe	356	22	)	)	-RRB-
cord-345472-qrddwebe	356	23	license	license	NN