id sid tid token lemma pos cord-345339-kyboibtq 1 1 key key NNP cord-345339-kyboibtq 1 2 : : : cord-345339-kyboibtq 1 3 cord-345339-kyboibtq cord-345339-kyboibtq ADD cord-345339-kyboibtq 2 1 authors author NNS cord-345339-kyboibtq 2 2 : : : cord-345339-kyboibtq 2 3 Steiner Steiner NNP cord-345339-kyboibtq 2 4 , , , cord-345339-kyboibtq 2 5 Israel Israel NNP cord-345339-kyboibtq 2 6 ; ; : cord-345339-kyboibtq 2 7 Nisipianu Nisipianu NNP cord-345339-kyboibtq 2 8 , , , cord-345339-kyboibtq 2 9 Puiu Puiu NNP cord-345339-kyboibtq 2 10 ; ; : cord-345339-kyboibtq 2 11 Wirguin Wirguin NNP cord-345339-kyboibtq 2 12 , , , cord-345339-kyboibtq 2 13 Itzhak Itzhak NNP cord-345339-kyboibtq 2 14 title title NN cord-345339-kyboibtq 2 15 : : : cord-345339-kyboibtq 2 16 Infection infection NN cord-345339-kyboibtq 2 17 and and CC cord-345339-kyboibtq 2 18 the the DT cord-345339-kyboibtq 2 19 etiology etiology NN cord-345339-kyboibtq 2 20 and and CC cord-345339-kyboibtq 2 21 pathogenesis pathogenesis NN cord-345339-kyboibtq 2 22 of of IN cord-345339-kyboibtq 2 23 multiple multiple JJ cord-345339-kyboibtq 2 24 sclerosis sclerosis NN cord-345339-kyboibtq 2 25 date date NN cord-345339-kyboibtq 2 26 : : : cord-345339-kyboibtq 2 27 2001 2001 CD cord-345339-kyboibtq 2 28 journal journal NN cord-345339-kyboibtq 2 29 : : : cord-345339-kyboibtq 3 1 Curr Curr NNP cord-345339-kyboibtq 3 2 Neurol Neurol NNP cord-345339-kyboibtq 3 3 Neurosci Neurosci NNP cord-345339-kyboibtq 3 4 Rep Rep NNP cord-345339-kyboibtq 3 5 DOI DOI NNP cord-345339-kyboibtq 3 6 : : : cord-345339-kyboibtq 4 1 10.1007 10.1007 CD cord-345339-kyboibtq 4 2 / / SYM cord-345339-kyboibtq 4 3 s11910 s11910 NNP cord-345339-kyboibtq 4 4 - - HYPH cord-345339-kyboibtq 4 5 001 001 CD cord-345339-kyboibtq 4 6 - - HYPH cord-345339-kyboibtq 4 7 0030-x 0030-x NNP cord-345339-kyboibtq 4 8 sha sha NNP cord-345339-kyboibtq 4 9 : : : cord-345339-kyboibtq 4 10 25581ff1072370c377c17eff901772e4ea802a71 25581ff1072370c377c17eff901772e4ea802a71 NNP cord-345339-kyboibtq 4 11 doc_id doc_id CD cord-345339-kyboibtq 4 12 : : : cord-345339-kyboibtq 4 13 345339 345339 CD cord-345339-kyboibtq 4 14 cord_uid cord_uid NNS cord-345339-kyboibtq 4 15 : : : cord-345339-kyboibtq 5 1 kyboibtq kyboibtq NNP cord-345339-kyboibtq 5 2 Multiple multiple JJ cord-345339-kyboibtq 5 3 sclerosis sclerosis NNP cord-345339-kyboibtq 5 4 ( ( -LRB- cord-345339-kyboibtq 5 5 MS MS NNP cord-345339-kyboibtq 5 6 ) ) -RRB- cord-345339-kyboibtq 5 7 currently currently RB cord-345339-kyboibtq 5 8 defies defy VBZ cord-345339-kyboibtq 5 9 clinical clinical JJ cord-345339-kyboibtq 5 10 and and CC cord-345339-kyboibtq 5 11 scientific scientific JJ cord-345339-kyboibtq 5 12 definitions definition NNS cord-345339-kyboibtq 5 13 , , , cord-345339-kyboibtq 5 14 and and CC cord-345339-kyboibtq 5 15 carries carry VBZ cord-345339-kyboibtq 5 16 a a DT cord-345339-kyboibtq 5 17 prognosis prognosis NN cord-345339-kyboibtq 5 18 that that WDT cord-345339-kyboibtq 5 19 remains remain VBZ cord-345339-kyboibtq 5 20 practically practically RB cord-345339-kyboibtq 5 21 unchanged unchanged JJ cord-345339-kyboibtq 5 22 despite despite IN cord-345339-kyboibtq 5 23 many many JJ cord-345339-kyboibtq 5 24 years year NNS cord-345339-kyboibtq 5 25 of of IN cord-345339-kyboibtq 5 26 intensive intensive JJ cord-345339-kyboibtq 5 27 research research NN cord-345339-kyboibtq 5 28 . . . cord-345339-kyboibtq 6 1 Although although IN cord-345339-kyboibtq 6 2 the the DT cord-345339-kyboibtq 6 3 prevailing prevail VBG cord-345339-kyboibtq 6 4 dogma dogma NN cord-345339-kyboibtq 6 5 is be VBZ cord-345339-kyboibtq 6 6 that that IN cord-345339-kyboibtq 6 7 MS MS NNP cord-345339-kyboibtq 6 8 is be VBZ cord-345339-kyboibtq 6 9 an an DT cord-345339-kyboibtq 6 10 immune immune NN cord-345339-kyboibtq 6 11 - - HYPH cord-345339-kyboibtq 6 12 mediated mediate VBN cord-345339-kyboibtq 6 13 condition condition NN cord-345339-kyboibtq 6 14 , , , cord-345339-kyboibtq 6 15 it -PRON- PRP cord-345339-kyboibtq 6 16 fulfills fulfill VBZ cord-345339-kyboibtq 6 17 none none NN cord-345339-kyboibtq 6 18 of of IN cord-345339-kyboibtq 6 19 the the DT cord-345339-kyboibtq 6 20 criteria criterion NNS cord-345339-kyboibtq 6 21 of of IN cord-345339-kyboibtq 6 22 an an DT cord-345339-kyboibtq 6 23 autoimmune autoimmune JJ cord-345339-kyboibtq 6 24 disease disease NN cord-345339-kyboibtq 6 25 . . . cord-345339-kyboibtq 7 1 On on IN cord-345339-kyboibtq 7 2 the the DT cord-345339-kyboibtq 7 3 other other JJ cord-345339-kyboibtq 7 4 hand hand NN cord-345339-kyboibtq 7 5 , , , cord-345339-kyboibtq 7 6 there there EX cord-345339-kyboibtq 7 7 is be VBZ cord-345339-kyboibtq 7 8 enough enough JJ cord-345339-kyboibtq 7 9 significant significant JJ cord-345339-kyboibtq 7 10 data datum NNS cord-345339-kyboibtq 7 11 to to TO cord-345339-kyboibtq 7 12 suggest suggest VB cord-345339-kyboibtq 7 13 that that IN cord-345339-kyboibtq 7 14 infectious infectious JJ cord-345339-kyboibtq 7 15 agents(s agents(s NNP cord-345339-kyboibtq 7 16 ) ) -RRB- cord-345339-kyboibtq 7 17 could could MD cord-345339-kyboibtq 7 18 be be VB cord-345339-kyboibtq 7 19 involved involve VBN cord-345339-kyboibtq 7 20 in in IN cord-345339-kyboibtq 7 21 either either CC cord-345339-kyboibtq 7 22 direct direct JJ cord-345339-kyboibtq 7 23 damage damage NN cord-345339-kyboibtq 7 24 to to IN cord-345339-kyboibtq 7 25 the the DT cord-345339-kyboibtq 7 26 white white JJ cord-345339-kyboibtq 7 27 matter matter NN cord-345339-kyboibtq 7 28 or or CC cord-345339-kyboibtq 7 29 induce induce VB cord-345339-kyboibtq 7 30 inflammatory inflammatory JJ cord-345339-kyboibtq 7 31 responses response NNS cord-345339-kyboibtq 7 32 that that WDT cord-345339-kyboibtq 7 33 secondarily secondarily RB cord-345339-kyboibtq 7 34 affect affect VBP cord-345339-kyboibtq 7 35 the the DT cord-345339-kyboibtq 7 36 brain brain NN cord-345339-kyboibtq 7 37 . . . cord-345339-kyboibtq 8 1 Our -PRON- PRP$ cord-345339-kyboibtq 8 2 goal goal NN cord-345339-kyboibtq 8 3 here here RB cord-345339-kyboibtq 8 4 is be VBZ cord-345339-kyboibtq 8 5 to to TO cord-345339-kyboibtq 8 6 review review VB cord-345339-kyboibtq 8 7 the the DT cord-345339-kyboibtq 8 8 data datum NNS cord-345339-kyboibtq 8 9 supporting support VBG cord-345339-kyboibtq 8 10 the the DT cord-345339-kyboibtq 8 11 possibility possibility NN cord-345339-kyboibtq 8 12 that that IN cord-345339-kyboibtq 8 13 infection infection NN cord-345339-kyboibtq 8 14 has have VBZ cord-345339-kyboibtq 8 15 a a DT cord-345339-kyboibtq 8 16 critical critical JJ cord-345339-kyboibtq 8 17 role role NN cord-345339-kyboibtq 8 18 in in IN cord-345339-kyboibtq 8 19 the the DT cord-345339-kyboibtq 8 20 disease disease NN cord-345339-kyboibtq 8 21 , , , cord-345339-kyboibtq 8 22 examine examine VB cord-345339-kyboibtq 8 23 the the DT cord-345339-kyboibtq 8 24 list list NN cord-345339-kyboibtq 8 25 of of IN cord-345339-kyboibtq 8 26 potential potential JJ cord-345339-kyboibtq 8 27 candidates candidate NNS cord-345339-kyboibtq 8 28 that that WDT cord-345339-kyboibtq 8 29 have have VBP cord-345339-kyboibtq 8 30 been be VBN cord-345339-kyboibtq 8 31 suggested suggest VBN cord-345339-kyboibtq 8 32 , , , cord-345339-kyboibtq 8 33 and and CC cord-345339-kyboibtq 8 34 outline outline VB cord-345339-kyboibtq 8 35 an an DT cord-345339-kyboibtq 8 36 approach approach NN cord-345339-kyboibtq 8 37 regarding regard VBG cord-345339-kyboibtq 8 38 the the DT cord-345339-kyboibtq 8 39 potential potential JJ cord-345339-kyboibtq 8 40 role role NN cord-345339-kyboibtq 8 41 of of IN cord-345339-kyboibtq 8 42 infectious infectious JJ cord-345339-kyboibtq 8 43 agents agent NNS cord-345339-kyboibtq 8 44 in in IN cord-345339-kyboibtq 8 45 the the DT cord-345339-kyboibtq 8 46 etiology etiology NN cord-345339-kyboibtq 8 47 and and CC cord-345339-kyboibtq 8 48 pathogenesis pathogenesis NN cord-345339-kyboibtq 8 49 of of IN cord-345339-kyboibtq 8 50 MS MS NNP cord-345339-kyboibtq 8 51 . . . cord-345339-kyboibtq 9 1 Despite despite IN cord-345339-kyboibtq 9 2 years year NNS cord-345339-kyboibtq 9 3 of of IN cord-345339-kyboibtq 9 4 investigation investigation NN cord-345339-kyboibtq 9 5 , , , cord-345339-kyboibtq 9 6 no no DT cord-345339-kyboibtq 9 7 direct direct JJ cord-345339-kyboibtq 9 8 evidence evidence NN cord-345339-kyboibtq 9 9 has have VBZ cord-345339-kyboibtq 9 10 been be VBN cord-345339-kyboibtq 9 11 found find VBN cord-345339-kyboibtq 9 12 to to TO cord-345339-kyboibtq 9 13 incriminate incriminate VB cord-345339-kyboibtq 9 14 a a DT cord-345339-kyboibtq 9 15 specific specific JJ cord-345339-kyboibtq 9 16 etiology etiology NN cord-345339-kyboibtq 9 17 and and CC cord-345339-kyboibtq 9 18 pathogenesis pathogenesis NN cord-345339-kyboibtq 9 19 for for IN cord-345339-kyboibtq 9 20 multiple multiple JJ cord-345339-kyboibtq 9 21 sclerosis sclerosis NN cord-345339-kyboibtq 9 22 ( ( -LRB- cord-345339-kyboibtq 9 23 MS MS NNP cord-345339-kyboibtq 9 24 ) ) -RRB- cord-345339-kyboibtq 9 25 . . . cord-345339-kyboibtq 10 1 Based base VBN cord-345339-kyboibtq 10 2 on on IN cord-345339-kyboibtq 10 3 meager meager JJ cord-345339-kyboibtq 10 4 evidence evidence NN cord-345339-kyboibtq 10 5 [ [ -LRB- cord-345339-kyboibtq 10 6 1• 1• CD cord-345339-kyboibtq 10 7 ] ] -RRB- cord-345339-kyboibtq 10 8 and and CC cord-345339-kyboibtq 10 9 on on IN cord-345339-kyboibtq 10 10 extrapolation extrapolation NN cord-345339-kyboibtq 10 11 , , , cord-345339-kyboibtq 10 12 an an DT cord-345339-kyboibtq 10 13 autoimmune autoimmune JJ cord-345339-kyboibtq 10 14 pathogenesis pathogenesis NN cord-345339-kyboibtq 10 15 has have VBZ cord-345339-kyboibtq 10 16 been be VBN cord-345339-kyboibtq 10 17 hypothesized hypothesize VBN cord-345339-kyboibtq 10 18 . . . cord-345339-kyboibtq 11 1 However however RB cord-345339-kyboibtq 11 2 , , , cord-345339-kyboibtq 11 3 we -PRON- PRP cord-345339-kyboibtq 11 4 feel feel VBP cord-345339-kyboibtq 11 5 that that IN cord-345339-kyboibtq 11 6 autoimmune autoimmune JJ cord-345339-kyboibtq 11 7 pathogenesis pathogenesis NN cord-345339-kyboibtq 11 8 is be VBZ cord-345339-kyboibtq 11 9 not not RB cord-345339-kyboibtq 11 10 the the DT cord-345339-kyboibtq 11 11 likely likely JJ cord-345339-kyboibtq 11 12 culprit culprit NN cord-345339-kyboibtq 11 13 ; ; : cord-345339-kyboibtq 11 14 instead instead RB cord-345339-kyboibtq 11 15 , , , cord-345339-kyboibtq 11 16 we -PRON- PRP cord-345339-kyboibtq 11 17 believe believe VBP cord-345339-kyboibtq 11 18 that that IN cord-345339-kyboibtq 11 19 infection infection NN cord-345339-kyboibtq 11 20 is be VBZ cord-345339-kyboibtq 11 21 more more RBR cord-345339-kyboibtq 11 22 likely likely RB cord-345339-kyboibtq 11 23 responsible responsible JJ cord-345339-kyboibtq 11 24 for for IN cord-345339-kyboibtq 11 25 the the DT cord-345339-kyboibtq 11 26 damage damage NN cord-345339-kyboibtq 11 27 to to IN cord-345339-kyboibtq 11 28 the the DT cord-345339-kyboibtq 11 29 central central JJ cord-345339-kyboibtq 11 30 nervous nervous JJ cord-345339-kyboibtq 11 31 system system NN cord-345339-kyboibtq 11 32 ( ( -LRB- cord-345339-kyboibtq 11 33 CNS CNS NNP cord-345339-kyboibtq 11 34 ) ) -RRB- cord-345339-kyboibtq 11 35 . . . cord-345339-kyboibtq 12 1 We -PRON- PRP cord-345339-kyboibtq 12 2 review review VBP cord-345339-kyboibtq 12 3 the the DT cord-345339-kyboibtq 12 4 data datum NNS cord-345339-kyboibtq 12 5 for for IN cord-345339-kyboibtq 12 6 an an DT cord-345339-kyboibtq 12 7 infectious infectious JJ cord-345339-kyboibtq 12 8 process process NN cord-345339-kyboibtq 12 9 and and CC cord-345339-kyboibtq 12 10 examine examine VB cord-345339-kyboibtq 12 11 the the DT cord-345339-kyboibtq 12 12 list list NN cord-345339-kyboibtq 12 13 of of IN cord-345339-kyboibtq 12 14 potential potential JJ cord-345339-kyboibtq 12 15 candidates candidate NNS cord-345339-kyboibtq 12 16 . . . cord-345339-kyboibtq 13 1 Multiple multiple JJ cord-345339-kyboibtq 13 2 sclerosis sclerosis NN cord-345339-kyboibtq 13 3 is be VBZ cord-345339-kyboibtq 13 4 a a DT cord-345339-kyboibtq 13 5 chronic chronic JJ cord-345339-kyboibtq 13 6 , , , cord-345339-kyboibtq 13 7 inflammatory inflammatory JJ cord-345339-kyboibtq 13 8 white white JJ cord-345339-kyboibtq 13 9 matter matter NN cord-345339-kyboibtq 13 10 disease disease NN cord-345339-kyboibtq 13 11 of of IN cord-345339-kyboibtq 13 12 the the DT cord-345339-kyboibtq 13 13 CNS CNS NNP cord-345339-kyboibtq 13 14 that that WDT cord-345339-kyboibtq 13 15 usually usually RB cord-345339-kyboibtq 13 16 affects affect VBZ cord-345339-kyboibtq 13 17 young young JJ cord-345339-kyboibtq 13 18 adults adult NNS cord-345339-kyboibtq 13 19 . . . cord-345339-kyboibtq 14 1 Successive successive JJ cord-345339-kyboibtq 14 2 sets set NNS cord-345339-kyboibtq 14 3 of of IN cord-345339-kyboibtq 14 4 diagnostic diagnostic JJ cord-345339-kyboibtq 14 5 criteria criterion NNS cord-345339-kyboibtq 14 6 , , , cord-345339-kyboibtq 14 7 essentially essentially RB cord-345339-kyboibtq 14 8 requiring require VBG cord-345339-kyboibtq 14 9 objective objective JJ cord-345339-kyboibtq 14 10 evidence evidence NN cord-345339-kyboibtq 14 11 of of IN cord-345339-kyboibtq 14 12 at at RB cord-345339-kyboibtq 14 13 least least JJS cord-345339-kyboibtq 14 14 two two CD cord-345339-kyboibtq 14 15 distinct distinct JJ cord-345339-kyboibtq 14 16 lesions lesion NNS cord-345339-kyboibtq 14 17 of of IN cord-345339-kyboibtq 14 18 CNS CNS NNP cord-345339-kyboibtq 14 19 white white JJ cord-345339-kyboibtq 14 20 matter matter NN cord-345339-kyboibtq 14 21 ( ( -LRB- cord-345339-kyboibtq 14 22 the the DT cord-345339-kyboibtq 14 23 last last JJ cord-345339-kyboibtq 14 24 set set NN cord-345339-kyboibtq 14 25 almost almost RB cord-345339-kyboibtq 14 26 20 20 CD cord-345339-kyboibtq 14 27 years year NNS cord-345339-kyboibtq 14 28 old old JJ cord-345339-kyboibtq 14 29 ) ) -RRB- cord-345339-kyboibtq 14 30 , , , cord-345339-kyboibtq 14 31 allude allude VBP cord-345339-kyboibtq 14 32 not not RB cord-345339-kyboibtq 14 33 only only RB cord-345339-kyboibtq 14 34 to to IN cord-345339-kyboibtq 14 35 the the DT cord-345339-kyboibtq 14 36 absence absence NN cord-345339-kyboibtq 14 37 of of IN cord-345339-kyboibtq 14 38 a a DT cord-345339-kyboibtq 14 39 pathognomonic pathognomonic JJ cord-345339-kyboibtq 14 40 test test NN cord-345339-kyboibtq 14 41 for for IN cord-345339-kyboibtq 14 42 MS MS NNP cord-345339-kyboibtq 14 43 , , , cord-345339-kyboibtq 14 44 but but CC cord-345339-kyboibtq 14 45 also also RB cord-345339-kyboibtq 14 46 to to IN cord-345339-kyboibtq 14 47 the the DT cord-345339-kyboibtq 14 48 lack lack NN cord-345339-kyboibtq 14 49 of of IN cord-345339-kyboibtq 14 50 adequate adequate JJ cord-345339-kyboibtq 14 51 evidence evidence NN cord-345339-kyboibtq 14 52 for for IN cord-345339-kyboibtq 14 53 the the DT cord-345339-kyboibtq 14 54 reliability reliability NN cord-345339-kyboibtq 14 55 of of IN cord-345339-kyboibtq 14 56 the the DT cord-345339-kyboibtq 14 57 various various JJ cord-345339-kyboibtq 14 58 criteria criterion NNS cord-345339-kyboibtq 14 59 . . . cord-345339-kyboibtq 15 1 Of of IN cord-345339-kyboibtq 15 2 note note NN cord-345339-kyboibtq 15 3 is be VBZ cord-345339-kyboibtq 15 4 the the DT cord-345339-kyboibtq 15 5 requirement requirement NN cord-345339-kyboibtq 15 6 for for IN cord-345339-kyboibtq 15 7 lack lack NN cord-345339-kyboibtq 15 8 of of IN cord-345339-kyboibtq 15 9 an an DT cord-345339-kyboibtq 15 10 alternative alternative JJ cord-345339-kyboibtq 15 11 diagnosis diagnosis NN cord-345339-kyboibtq 15 12 [ [ -LRB- cord-345339-kyboibtq 15 13 2 2 CD cord-345339-kyboibtq 15 14 ] ] -RRB- cord-345339-kyboibtq 15 15 , , , cord-345339-kyboibtq 15 16 a a DT cord-345339-kyboibtq 15 17 criterion criterion NN cord-345339-kyboibtq 15 18 that that WDT cord-345339-kyboibtq 15 19 imposes impose VBZ cord-345339-kyboibtq 15 20 an an DT cord-345339-kyboibtq 15 21 element element NN cord-345339-kyboibtq 15 22 of of IN cord-345339-kyboibtq 15 23 " " `` cord-345339-kyboibtq 15 24 diagnosis diagnosis NN cord-345339-kyboibtq 15 25 by by IN cord-345339-kyboibtq 15 26 exclusion exclusion NN cord-345339-kyboibtq 15 27 . . . cord-345339-kyboibtq 16 1 " " `` cord-345339-kyboibtq 16 2 The the DT cord-345339-kyboibtq 16 3 white white JJ cord-345339-kyboibtq 16 4 matter matter NN cord-345339-kyboibtq 16 5 is be VBZ cord-345339-kyboibtq 16 6 progressively progressively RB cord-345339-kyboibtq 16 7 destroyed destroy VBN cord-345339-kyboibtq 16 8 , , , cord-345339-kyboibtq 16 9 leaving leave VBG cord-345339-kyboibtq 16 10 some some DT cord-345339-kyboibtq 16 11 of of IN cord-345339-kyboibtq 16 12 the the DT cord-345339-kyboibtq 16 13 victims victim NNS cord-345339-kyboibtq 16 14 incapacitated incapacitate VBN cord-345339-kyboibtq 16 15 for for IN cord-345339-kyboibtq 16 16 life life NN cord-345339-kyboibtq 16 17 . . . cord-345339-kyboibtq 17 1 For for IN cord-345339-kyboibtq 17 2 many many JJ cord-345339-kyboibtq 17 3 years year NNS cord-345339-kyboibtq 17 4 , , , cord-345339-kyboibtq 17 5 the the DT cord-345339-kyboibtq 17 6 leading lead VBG cord-345339-kyboibtq 17 7 , , , cord-345339-kyboibtq 17 8 and and CC cord-345339-kyboibtq 17 9 practically practically RB cord-345339-kyboibtq 17 10 dogmatic dogmatic JJ cord-345339-kyboibtq 17 11 , , , cord-345339-kyboibtq 17 12 hypothesis hypothesis NN cord-345339-kyboibtq 17 13 has have VBZ cord-345339-kyboibtq 17 14 been be VBN cord-345339-kyboibtq 17 15 that that IN cord-345339-kyboibtq 17 16 MS MS NNP cord-345339-kyboibtq 17 17 is be VBZ cord-345339-kyboibtq 17 18 an an DT cord-345339-kyboibtq 17 19 autoimmune autoimmune JJ cord-345339-kyboibtq 17 20 condition condition NN cord-345339-kyboibtq 17 21 and and CC cord-345339-kyboibtq 17 22 hence hence RB cord-345339-kyboibtq 17 23 , , , cord-345339-kyboibtq 17 24 that that IN cord-345339-kyboibtq 17 25 its -PRON- PRP$ cord-345339-kyboibtq 17 26 symptoms symptom NNS cord-345339-kyboibtq 17 27 and and CC cord-345339-kyboibtq 17 28 progression progression NN cord-345339-kyboibtq 17 29 could could MD cord-345339-kyboibtq 17 30 be be VB cord-345339-kyboibtq 17 31 ameliorated ameliorate VBN cord-345339-kyboibtq 17 32 by by IN cord-345339-kyboibtq 17 33 immunomodulating immunomodulate VBG cord-345339-kyboibtq 17 34 strategies strategy NNS cord-345339-kyboibtq 17 35 . . . cord-345339-kyboibtq 18 1 However however RB cord-345339-kyboibtq 18 2 , , , cord-345339-kyboibtq 18 3 while while IN cord-345339-kyboibtq 18 4 the the DT cord-345339-kyboibtq 18 5 field field NN cord-345339-kyboibtq 18 6 of of IN cord-345339-kyboibtq 18 7 neuroimmunology neuroimmunology NN cord-345339-kyboibtq 18 8 has have VBZ cord-345339-kyboibtq 18 9 thrived thrive VBN cord-345339-kyboibtq 18 10 , , , cord-345339-kyboibtq 18 11 little little JJ cord-345339-kyboibtq 18 12 progress progress NN cord-345339-kyboibtq 18 13 has have VBZ cord-345339-kyboibtq 18 14 been be VBN cord-345339-kyboibtq 18 15 made make VBN cord-345339-kyboibtq 18 16 towards towards IN cord-345339-kyboibtq 18 17 understanding understand VBG cord-345339-kyboibtq 18 18 MS MS NNP cord-345339-kyboibtq 18 19 . . . cord-345339-kyboibtq 19 1 The the DT cord-345339-kyboibtq 19 2 current current JJ cord-345339-kyboibtq 19 3 diagnostic diagnostic JJ cord-345339-kyboibtq 19 4 criteria criterion NNS cord-345339-kyboibtq 19 5 accommodate accommodate VBP cord-345339-kyboibtq 19 6 a a DT cord-345339-kyboibtq 19 7 wide wide JJ cord-345339-kyboibtq 19 8 range range NN cord-345339-kyboibtq 19 9 of of IN cord-345339-kyboibtq 19 10 conditions condition NNS cord-345339-kyboibtq 19 11 . . . cord-345339-kyboibtq 20 1 Indeed indeed RB cord-345339-kyboibtq 20 2 , , , cord-345339-kyboibtq 20 3 the the DT cord-345339-kyboibtq 20 4 extremely extremely RB cord-345339-kyboibtq 20 5 variable variable JJ cord-345339-kyboibtq 20 6 course course NN cord-345339-kyboibtq 20 7 and and CC cord-345339-kyboibtq 20 8 prognosis prognosis NN cord-345339-kyboibtq 20 9 of of IN cord-345339-kyboibtq 20 10 the the DT cord-345339-kyboibtq 20 11 disease disease NN cord-345339-kyboibtq 20 12 suggest suggest VBP cord-345339-kyboibtq 20 13 that that IN cord-345339-kyboibtq 20 14 what what WP cord-345339-kyboibtq 20 15 is be VBZ cord-345339-kyboibtq 20 16 considered consider VBN cord-345339-kyboibtq 20 17 today today NN cord-345339-kyboibtq 20 18 a a DT cord-345339-kyboibtq 20 19 homogenous homogenous JJ cord-345339-kyboibtq 20 20 and and CC cord-345339-kyboibtq 20 21 consistent consistent JJ cord-345339-kyboibtq 20 22 entity entity NN cord-345339-kyboibtq 20 23 of of IN cord-345339-kyboibtq 20 24 similar similar JJ cord-345339-kyboibtq 20 25 etiology etiology NN cord-345339-kyboibtq 20 26 and and CC cord-345339-kyboibtq 20 27 pathogenesis pathogenesis NN cord-345339-kyboibtq 20 28 , , , cord-345339-kyboibtq 20 29 is be VBZ cord-345339-kyboibtq 20 30 , , , cord-345339-kyboibtq 20 31 in in IN cord-345339-kyboibtq 20 32 fact fact NN cord-345339-kyboibtq 20 33 , , , cord-345339-kyboibtq 20 34 a a DT cord-345339-kyboibtq 20 35 syndrome syndrome NN cord-345339-kyboibtq 20 36 caused cause VBN cord-345339-kyboibtq 20 37 by by IN cord-345339-kyboibtq 20 38 various various JJ cord-345339-kyboibtq 20 39 etiologies etiology NNS cord-345339-kyboibtq 20 40 and and CC cord-345339-kyboibtq 20 41 multiple multiple JJ cord-345339-kyboibtq 20 42 pathogenic pathogenic JJ cord-345339-kyboibtq 20 43 mechanisms mechanism NNS cord-345339-kyboibtq 20 44 [ [ -LRB- cord-345339-kyboibtq 20 45 1• 1• CD cord-345339-kyboibtq 20 46 ] ] -RRB- cord-345339-kyboibtq 20 47 . . . cord-345339-kyboibtq 21 1 Pierre Pierre NNP cord-345339-kyboibtq 21 2 Marie Marie NNP cord-345339-kyboibtq 21 3 , , , cord-345339-kyboibtq 21 4 Charcot Charcot NNP cord-345339-kyboibtq 21 5 's 's POS cord-345339-kyboibtq 21 6 favorite favorite JJ cord-345339-kyboibtq 21 7 student student NN cord-345339-kyboibtq 21 8 , , , cord-345339-kyboibtq 21 9 ( ( -LRB- cord-345339-kyboibtq 21 10 but but CC cord-345339-kyboibtq 21 11 not not RB cord-345339-kyboibtq 21 12 his -PRON- PRP$ cord-345339-kyboibtq 21 13 successor successor NN cord-345339-kyboibtq 21 14 , , , cord-345339-kyboibtq 21 15 as as IN cord-345339-kyboibtq 21 16 erroneously erroneously RB cord-345339-kyboibtq 21 17 suggested suggest VBN cord-345339-kyboibtq 21 18 by by IN cord-345339-kyboibtq 21 19 several several JJ cord-345339-kyboibtq 21 20 reviews review NNS cord-345339-kyboibtq 21 21 ) ) -RRB- cord-345339-kyboibtq 21 22 , , , cord-345339-kyboibtq 21 23 was be VBD cord-345339-kyboibtq 21 24 the the DT cord-345339-kyboibtq 21 25 first first JJ cord-345339-kyboibtq 21 26 , , , cord-345339-kyboibtq 21 27 at at IN cord-345339-kyboibtq 21 28 the the DT cord-345339-kyboibtq 21 29 end end NN cord-345339-kyboibtq 21 30 of of IN cord-345339-kyboibtq 21 31 the the DT cord-345339-kyboibtq 21 32 19th 19th JJ cord-345339-kyboibtq 21 33 century century NN cord-345339-kyboibtq 21 34 , , , cord-345339-kyboibtq 21 35 to to TO cord-345339-kyboibtq 21 36 raise raise VB cord-345339-kyboibtq 21 37 the the DT cord-345339-kyboibtq 21 38 possibility possibility NN cord-345339-kyboibtq 21 39 that that IN cord-345339-kyboibtq 21 40 MS MS NNP cord-345339-kyboibtq 21 41 is be VBZ cord-345339-kyboibtq 21 42 caused cause VBN cord-345339-kyboibtq 21 43 by by IN cord-345339-kyboibtq 21 44 an an DT cord-345339-kyboibtq 21 45 infection infection NN cord-345339-kyboibtq 21 46 [ [ -LRB- cord-345339-kyboibtq 21 47 3 3 CD cord-345339-kyboibtq 21 48 ] ] -RRB- cord-345339-kyboibtq 21 49 . . . cord-345339-kyboibtq 22 1 Since since IN cord-345339-kyboibtq 22 2 then then RB cord-345339-kyboibtq 22 3 , , , cord-345339-kyboibtq 22 4 the the DT cord-345339-kyboibtq 22 5 amount amount NN cord-345339-kyboibtq 22 6 of of IN cord-345339-kyboibtq 22 7 information information NN cord-345339-kyboibtq 22 8 in in IN cord-345339-kyboibtq 22 9 this this DT cord-345339-kyboibtq 22 10 realm realm NN cord-345339-kyboibtq 22 11 is be VBZ cord-345339-kyboibtq 22 12 overwhelming overwhelming JJ cord-345339-kyboibtq 22 13 . . . cord-345339-kyboibtq 23 1 Our -PRON- PRP$ cord-345339-kyboibtq 23 2 goal goal NN cord-345339-kyboibtq 23 3 here here RB cord-345339-kyboibtq 23 4 is be VBZ cord-345339-kyboibtq 23 5 not not RB cord-345339-kyboibtq 23 6 to to TO cord-345339-kyboibtq 23 7 quote quote VB cord-345339-kyboibtq 23 8 the the DT cord-345339-kyboibtq 23 9 copious copious JJ cord-345339-kyboibtq 23 10 literature literature NN cord-345339-kyboibtq 23 11 , , , cord-345339-kyboibtq 23 12 but but CC cord-345339-kyboibtq 23 13 to to TO cord-345339-kyboibtq 23 14 delineate delineate VB cord-345339-kyboibtq 23 15 concepts concept NNS cord-345339-kyboibtq 23 16 , , , cord-345339-kyboibtq 23 17 outline outline VB cord-345339-kyboibtq 23 18 an an DT cord-345339-kyboibtq 23 19 approach approach NN cord-345339-kyboibtq 23 20 , , , cord-345339-kyboibtq 23 21 and and CC cord-345339-kyboibtq 23 22 provide provide VB cord-345339-kyboibtq 23 23 some some DT cord-345339-kyboibtq 23 24 food food NN cord-345339-kyboibtq 23 25 for for IN cord-345339-kyboibtq 23 26 thought thought NN cord-345339-kyboibtq 23 27 regarding regard VBG cord-345339-kyboibtq 23 28 the the DT cord-345339-kyboibtq 23 29 possible possible JJ cord-345339-kyboibtq 23 30 role role NN cord-345339-kyboibtq 23 31 of of IN cord-345339-kyboibtq 23 32 infectious infectious JJ cord-345339-kyboibtq 23 33 agents agent NNS cord-345339-kyboibtq 23 34 in in IN cord-345339-kyboibtq 23 35 the the DT cord-345339-kyboibtq 23 36 etiology etiology NN cord-345339-kyboibtq 23 37 and and CC cord-345339-kyboibtq 23 38 pathogenesis pathogenesis NN cord-345339-kyboibtq 23 39 MS MS NNP cord-345339-kyboibtq 23 40 . . . cord-345339-kyboibtq 24 1 Basically basically RB cord-345339-kyboibtq 24 2 , , , cord-345339-kyboibtq 24 3 an an DT cord-345339-kyboibtq 24 4 infective infective JJ cord-345339-kyboibtq 24 5 process process NN cord-345339-kyboibtq 24 6 can can MD cord-345339-kyboibtq 24 7 damage damage VB cord-345339-kyboibtq 24 8 the the DT cord-345339-kyboibtq 24 9 tissue tissue NN cord-345339-kyboibtq 24 10 via via IN cord-345339-kyboibtq 24 11 two two CD cord-345339-kyboibtq 24 12 major major JJ cord-345339-kyboibtq 24 13 avenues avenue NNS cord-345339-kyboibtq 24 14 : : : cord-345339-kyboibtq 24 15 directly directly RB cord-345339-kyboibtq 24 16 , , , cord-345339-kyboibtq 24 17 due due IN cord-345339-kyboibtq 24 18 to to IN cord-345339-kyboibtq 24 19 the the DT cord-345339-kyboibtq 24 20 pathogen pathogen NN cord-345339-kyboibtq 24 21 present present JJ cord-345339-kyboibtq 24 22 in in IN cord-345339-kyboibtq 24 23 the the DT cord-345339-kyboibtq 24 24 tissue tissue NN cord-345339-kyboibtq 24 25 during during IN cord-345339-kyboibtq 24 26 the the DT cord-345339-kyboibtq 24 27 disease disease NN cord-345339-kyboibtq 24 28 ; ; : cord-345339-kyboibtq 24 29 or or CC cord-345339-kyboibtq 24 30 indirectly indirectly RB cord-345339-kyboibtq 24 31 , , , cord-345339-kyboibtq 24 32 where where WRB cord-345339-kyboibtq 24 33 the the DT cord-345339-kyboibtq 24 34 infection infection NN cord-345339-kyboibtq 24 35 is be VBZ cord-345339-kyboibtq 24 36 only only RB cord-345339-kyboibtq 24 37 the the DT cord-345339-kyboibtq 24 38 trigger trigger NN cord-345339-kyboibtq 24 39 , , , cord-345339-kyboibtq 24 40 and and CC cord-345339-kyboibtq 24 41 the the DT cord-345339-kyboibtq 24 42 damage damage NN cord-345339-kyboibtq 24 43 occurs occur VBZ cord-345339-kyboibtq 24 44 while while IN cord-345339-kyboibtq 24 45 the the DT cord-345339-kyboibtq 24 46 infection infection NN cord-345339-kyboibtq 24 47 has have VBZ cord-345339-kyboibtq 24 48 already already RB cord-345339-kyboibtq 24 49 been be VBN cord-345339-kyboibtq 24 50 cleared clear VBN cord-345339-kyboibtq 24 51 and and CC cord-345339-kyboibtq 24 52 removed remove VBN cord-345339-kyboibtq 24 53 from from IN cord-345339-kyboibtq 24 54 the the DT cord-345339-kyboibtq 24 55 organism organism NN cord-345339-kyboibtq 24 56 . . . cord-345339-kyboibtq 25 1 Each each DT cord-345339-kyboibtq 25 2 alternative alternative NN cord-345339-kyboibtq 25 3 has have VBZ cord-345339-kyboibtq 25 4 different different JJ cord-345339-kyboibtq 25 5 histologic histologic JJ cord-345339-kyboibtq 25 6 , , , cord-345339-kyboibtq 25 7 serologic serologic NN cord-345339-kyboibtq 25 8 , , , cord-345339-kyboibtq 25 9 and and CC cord-345339-kyboibtq 25 10 epidemiologic epidemiologic JJ cord-345339-kyboibtq 25 11 characteristics characteristic NNS cord-345339-kyboibtq 25 12 . . . cord-345339-kyboibtq 26 1 Multiple multiple JJ cord-345339-kyboibtq 26 2 sclerosis sclerosis NN cord-345339-kyboibtq 26 3 lesions lesion NNS cord-345339-kyboibtq 26 4 ( ( -LRB- cord-345339-kyboibtq 26 5 plaques plaque NNS cord-345339-kyboibtq 26 6 ) ) -RRB- cord-345339-kyboibtq 26 7 are be VBP cord-345339-kyboibtq 26 8 multifocal multifocal JJ cord-345339-kyboibtq 26 9 and and CC cord-345339-kyboibtq 26 10 mainly mainly RB cord-345339-kyboibtq 26 11 perivenous perivenous NNP cord-345339-kyboibtq 26 12 [ [ -LRB- cord-345339-kyboibtq 26 13 4•• 4•• CD cord-345339-kyboibtq 26 14 ] ] -RRB- cord-345339-kyboibtq 26 15 . . . cord-345339-kyboibtq 27 1 Their -PRON- PRP$ cord-345339-kyboibtq 27 2 distribution distribution NN cord-345339-kyboibtq 27 3 , , , cord-345339-kyboibtq 27 4 though though IN cord-345339-kyboibtq 27 5 random random JJ cord-345339-kyboibtq 27 6 enough enough RB cord-345339-kyboibtq 27 7 to to TO cord-345339-kyboibtq 27 8 merit merit VB cord-345339-kyboibtq 27 9 conflicting conflicting JJ cord-345339-kyboibtq 27 10 generalizations generalization NNS cord-345339-kyboibtq 27 11 and and CC cord-345339-kyboibtq 27 12 conclusions conclusion NNS cord-345339-kyboibtq 27 13 , , , cord-345339-kyboibtq 27 14 can can MD cord-345339-kyboibtq 27 15 reflect reflect VB cord-345339-kyboibtq 27 16 the the DT cord-345339-kyboibtq 27 17 route route NN cord-345339-kyboibtq 27 18 of of IN cord-345339-kyboibtq 27 19 penetration penetration NN cord-345339-kyboibtq 27 20 of of IN cord-345339-kyboibtq 27 21 infection infection NN cord-345339-kyboibtq 27 22 . . . cord-345339-kyboibtq 28 1 The the DT cord-345339-kyboibtq 28 2 myelin myelin NN cord-345339-kyboibtq 28 3 loss loss NN cord-345339-kyboibtq 28 4 , , , cord-345339-kyboibtq 28 5 with with IN cord-345339-kyboibtq 28 6 neurons neuron NNS cord-345339-kyboibtq 28 7 and and CC cord-345339-kyboibtq 28 8 axons axon NNS cord-345339-kyboibtq 28 9 being be VBG cord-345339-kyboibtq 28 10 relatively relatively RB cord-345339-kyboibtq 28 11 spared spare VBN cord-345339-kyboibtq 28 12 , , , cord-345339-kyboibtq 28 13 which which WDT cord-345339-kyboibtq 28 14 is be VBZ cord-345339-kyboibtq 28 15 characteristic characteristic JJ cord-345339-kyboibtq 28 16 of of IN cord-345339-kyboibtq 28 17 the the DT cord-345339-kyboibtq 28 18 MS MS NNP cord-345339-kyboibtq 28 19 lesion lesion NN cord-345339-kyboibtq 28 20 , , , cord-345339-kyboibtq 28 21 is be VBZ cord-345339-kyboibtq 28 22 associated associate VBN cord-345339-kyboibtq 28 23 with with IN cord-345339-kyboibtq 28 24 mononuclear mononuclear JJ cord-345339-kyboibtq 28 25 inflammatory inflammatory JJ cord-345339-kyboibtq 28 26 cell cell NN cord-345339-kyboibtq 28 27 infiltrates infiltrate VBZ cord-345339-kyboibtq 28 28 within within IN cord-345339-kyboibtq 28 29 active active JJ cord-345339-kyboibtq 28 30 plaques plaque NNS cord-345339-kyboibtq 28 31 and and CC cord-345339-kyboibtq 28 32 in in IN cord-345339-kyboibtq 28 33 perivascular perivascular JJ cord-345339-kyboibtq 28 34 spaces space NNS cord-345339-kyboibtq 28 35 . . . cord-345339-kyboibtq 29 1 Macrophages macrophage NNS cord-345339-kyboibtq 29 2 and and CC cord-345339-kyboibtq 29 3 T t NN cord-345339-kyboibtq 29 4 lymphocytes lymphocyte NNS cord-345339-kyboibtq 29 5 are be VBP cord-345339-kyboibtq 29 6 present present JJ cord-345339-kyboibtq 29 7 in in IN cord-345339-kyboibtq 29 8 the the DT cord-345339-kyboibtq 29 9 center center NN cord-345339-kyboibtq 29 10 of of IN cord-345339-kyboibtq 29 11 a a DT cord-345339-kyboibtq 29 12 new new JJ cord-345339-kyboibtq 29 13 lesion lesion NN cord-345339-kyboibtq 29 14 , , , cord-345339-kyboibtq 29 15 which which WDT cord-345339-kyboibtq 29 16 also also RB cord-345339-kyboibtq 29 17 shows show VBZ cord-345339-kyboibtq 29 18 reduction reduction NN cord-345339-kyboibtq 29 19 in in IN cord-345339-kyboibtq 29 20 the the DT cord-345339-kyboibtq 29 21 number number NN cord-345339-kyboibtq 29 22 of of IN cord-345339-kyboibtq 29 23 oligodendrocytes oligodendrocyte NNS cord-345339-kyboibtq 29 24 , , , cord-345339-kyboibtq 29 25 reactive reactive JJ cord-345339-kyboibtq 29 26 astrocytes astrocyte NNS cord-345339-kyboibtq 29 27 , , , cord-345339-kyboibtq 29 28 and and CC cord-345339-kyboibtq 29 29 microglial microglial JJ cord-345339-kyboibtq 29 30 cells cell NNS cord-345339-kyboibtq 29 31 . . . cord-345339-kyboibtq 30 1 Obviously obviously RB cord-345339-kyboibtq 30 2 , , , cord-345339-kyboibtq 30 3 these these DT cord-345339-kyboibtq 30 4 findings finding NNS cord-345339-kyboibtq 30 5 may may MD cord-345339-kyboibtq 30 6 accompany accompany VB cord-345339-kyboibtq 30 7 an an DT cord-345339-kyboibtq 30 8 active active JJ cord-345339-kyboibtq 30 9 ongoing ongoing JJ cord-345339-kyboibtq 30 10 infectious infectious JJ cord-345339-kyboibtq 30 11 process process NN cord-345339-kyboibtq 30 12 . . . cord-345339-kyboibtq 31 1 The the DT cord-345339-kyboibtq 31 2 predilection predilection NN cord-345339-kyboibtq 31 3 of of IN cord-345339-kyboibtq 31 4 the the DT cord-345339-kyboibtq 31 5 inflammation inflammation NN cord-345339-kyboibtq 31 6 for for IN cord-345339-kyboibtq 31 7 the the DT cord-345339-kyboibtq 31 8 white white JJ cord-345339-kyboibtq 31 9 matter matter NN cord-345339-kyboibtq 31 10 is be VBZ cord-345339-kyboibtq 31 11 a a DT cord-345339-kyboibtq 31 12 Multiple multiple JJ cord-345339-kyboibtq 31 13 sclerosis sclerosis NN cord-345339-kyboibtq 31 14 ( ( -LRB- cord-345339-kyboibtq 31 15 MS MS NNP cord-345339-kyboibtq 31 16 ) ) -RRB- cord-345339-kyboibtq 31 17 currently currently RB cord-345339-kyboibtq 31 18 defies defy VBZ cord-345339-kyboibtq 31 19 clinical clinical JJ cord-345339-kyboibtq 31 20 and and CC cord-345339-kyboibtq 31 21 scientific scientific JJ cord-345339-kyboibtq 31 22 definitions definition NNS cord-345339-kyboibtq 31 23 , , , cord-345339-kyboibtq 31 24 and and CC cord-345339-kyboibtq 31 25 carries carry VBZ cord-345339-kyboibtq 31 26 a a DT cord-345339-kyboibtq 31 27 prognosis prognosis NN cord-345339-kyboibtq 31 28 that that WDT cord-345339-kyboibtq 31 29 remains remain VBZ cord-345339-kyboibtq 31 30 practically practically RB cord-345339-kyboibtq 31 31 unchanged unchanged JJ cord-345339-kyboibtq 31 32 despite despite IN cord-345339-kyboibtq 31 33 many many JJ cord-345339-kyboibtq 31 34 years year NNS cord-345339-kyboibtq 31 35 of of IN cord-345339-kyboibtq 31 36 intensive intensive JJ cord-345339-kyboibtq 31 37 research research NN cord-345339-kyboibtq 31 38 . . . cord-345339-kyboibtq 32 1 Although although IN cord-345339-kyboibtq 32 2 the the DT cord-345339-kyboibtq 32 3 prevailing prevail VBG cord-345339-kyboibtq 32 4 dogma dogma NN cord-345339-kyboibtq 32 5 is be VBZ cord-345339-kyboibtq 32 6 that that IN cord-345339-kyboibtq 32 7 MS MS NNP cord-345339-kyboibtq 32 8 is be VBZ cord-345339-kyboibtq 32 9 an an DT cord-345339-kyboibtq 32 10 immune immune NN cord-345339-kyboibtq 32 11 - - HYPH cord-345339-kyboibtq 32 12 mediated mediate VBN cord-345339-kyboibtq 32 13 condition condition NN cord-345339-kyboibtq 32 14 , , , cord-345339-kyboibtq 32 15 it -PRON- PRP cord-345339-kyboibtq 32 16 fulfills fulfill VBZ cord-345339-kyboibtq 32 17 none none NN cord-345339-kyboibtq 32 18 of of IN cord-345339-kyboibtq 32 19 the the DT cord-345339-kyboibtq 32 20 criteria criterion NNS cord-345339-kyboibtq 32 21 of of IN cord-345339-kyboibtq 32 22 an an DT cord-345339-kyboibtq 32 23 autoimmune autoimmune JJ cord-345339-kyboibtq 32 24 disease disease NN cord-345339-kyboibtq 32 25 . . . cord-345339-kyboibtq 33 1 On on IN cord-345339-kyboibtq 33 2 the the DT cord-345339-kyboibtq 33 3 other other JJ cord-345339-kyboibtq 33 4 hand hand NN cord-345339-kyboibtq 33 5 , , , cord-345339-kyboibtq 33 6 there there EX cord-345339-kyboibtq 33 7 is be VBZ cord-345339-kyboibtq 33 8 enough enough JJ cord-345339-kyboibtq 33 9 significant significant JJ cord-345339-kyboibtq 33 10 data datum NNS cord-345339-kyboibtq 33 11 to to TO cord-345339-kyboibtq 33 12 suggest suggest VB cord-345339-kyboibtq 33 13 that that IN cord-345339-kyboibtq 33 14 infectious infectious JJ cord-345339-kyboibtq 33 15 agents(s agents(s NNP cord-345339-kyboibtq 33 16 ) ) -RRB- cord-345339-kyboibtq 33 17 could could MD cord-345339-kyboibtq 33 18 be be VB cord-345339-kyboibtq 33 19 involved involve VBN cord-345339-kyboibtq 33 20 in in IN cord-345339-kyboibtq 33 21 either either CC cord-345339-kyboibtq 33 22 direct direct JJ cord-345339-kyboibtq 33 23 damage damage NN cord-345339-kyboibtq 33 24 to to IN cord-345339-kyboibtq 33 25 the the DT cord-345339-kyboibtq 33 26 white white JJ cord-345339-kyboibtq 33 27 matter matter NN cord-345339-kyboibtq 33 28 or or CC cord-345339-kyboibtq 33 29 induce induce VB cord-345339-kyboibtq 33 30 inflammatory inflammatory JJ cord-345339-kyboibtq 33 31 responses response NNS cord-345339-kyboibtq 33 32 that that WDT cord-345339-kyboibtq 33 33 secondarily secondarily RB cord-345339-kyboibtq 33 34 affect affect VBP cord-345339-kyboibtq 33 35 the the DT cord-345339-kyboibtq 33 36 brain brain NN cord-345339-kyboibtq 33 37 . . . cord-345339-kyboibtq 34 1 Our -PRON- PRP$ cord-345339-kyboibtq 34 2 goal goal NN cord-345339-kyboibtq 34 3 here here RB cord-345339-kyboibtq 34 4 is be VBZ cord-345339-kyboibtq 34 5 to to TO cord-345339-kyboibtq 34 6 review review VB cord-345339-kyboibtq 34 7 the the DT cord-345339-kyboibtq 34 8 data datum NNS cord-345339-kyboibtq 34 9 supporting support VBG cord-345339-kyboibtq 34 10 the the DT cord-345339-kyboibtq 34 11 possibility possibility NN cord-345339-kyboibtq 34 12 that that IN cord-345339-kyboibtq 34 13 infection infection NN cord-345339-kyboibtq 34 14 has have VBZ cord-345339-kyboibtq 34 15 a a DT cord-345339-kyboibtq 34 16 critical critical JJ cord-345339-kyboibtq 34 17 role role NN cord-345339-kyboibtq 34 18 in in IN cord-345339-kyboibtq 34 19 the the DT cord-345339-kyboibtq 34 20 disease disease NN cord-345339-kyboibtq 34 21 , , , cord-345339-kyboibtq 34 22 examine examine VB cord-345339-kyboibtq 34 23 the the DT cord-345339-kyboibtq 34 24 list list NN cord-345339-kyboibtq 34 25 of of IN cord-345339-kyboibtq 34 26 potential potential JJ cord-345339-kyboibtq 34 27 candidates candidate NNS cord-345339-kyboibtq 34 28 that that WDT cord-345339-kyboibtq 34 29 have have VBP cord-345339-kyboibtq 34 30 been be VBN cord-345339-kyboibtq 34 31 suggested suggest VBN cord-345339-kyboibtq 34 32 , , , cord-345339-kyboibtq 34 33 and and CC cord-345339-kyboibtq 34 34 outline outline VB cord-345339-kyboibtq 34 35 an an DT cord-345339-kyboibtq 34 36 approach approach NN cord-345339-kyboibtq 34 37 regarding regard VBG cord-345339-kyboibtq 34 38 the the DT cord-345339-kyboibtq 34 39 potential potential JJ cord-345339-kyboibtq 34 40 role role NN cord-345339-kyboibtq 34 41 of of IN cord-345339-kyboibtq 34 42 infectious infectious JJ cord-345339-kyboibtq 34 43 agents agent NNS cord-345339-kyboibtq 34 44 in in IN cord-345339-kyboibtq 34 45 the the DT cord-345339-kyboibtq 34 46 etiology etiology NN cord-345339-kyboibtq 34 47 and and CC cord-345339-kyboibtq 34 48 pathogenesis pathogenesis NN cord-345339-kyboibtq 34 49 of of IN cord-345339-kyboibtq 34 50 MS MS NNP cord-345339-kyboibtq 34 51 . . . cord-345339-kyboibtq 35 1 relatively relatively RB cord-345339-kyboibtq 35 2 uncommon uncommon JJ cord-345339-kyboibtq 35 3 feature feature NN cord-345339-kyboibtq 35 4 of of IN cord-345339-kyboibtq 35 5 acute acute JJ cord-345339-kyboibtq 35 6 viral viral JJ cord-345339-kyboibtq 35 7 infections infection NNS cord-345339-kyboibtq 35 8 of of IN cord-345339-kyboibtq 35 9 the the DT cord-345339-kyboibtq 35 10 CNS CNS NNP cord-345339-kyboibtq 35 11 , , , cord-345339-kyboibtq 35 12 and and CC cord-345339-kyboibtq 35 13 has have VBZ cord-345339-kyboibtq 35 14 been be VBN cord-345339-kyboibtq 35 15 noted note VBN cord-345339-kyboibtq 35 16 mainly mainly RB cord-345339-kyboibtq 35 17 in in IN cord-345339-kyboibtq 35 18 certain certain JJ cord-345339-kyboibtq 35 19 chronic chronic JJ cord-345339-kyboibtq 35 20 viral viral JJ cord-345339-kyboibtq 35 21 infections infection NNS cord-345339-kyboibtq 35 22 ( ( -LRB- cord-345339-kyboibtq 35 23 see see VB cord-345339-kyboibtq 35 24 following follow VBG cord-345339-kyboibtq 35 25 ) ) -RRB- cord-345339-kyboibtq 35 26 . . . cord-345339-kyboibtq 36 1 This this DT cord-345339-kyboibtq 36 2 discipline discipline NN cord-345339-kyboibtq 36 3 has have VBZ cord-345339-kyboibtq 36 4 provided provide VBN cord-345339-kyboibtq 36 5 compelling compelling JJ cord-345339-kyboibtq 36 6 evidence evidence NN cord-345339-kyboibtq 36 7 for for IN cord-345339-kyboibtq 36 8 an an DT cord-345339-kyboibtq 36 9 environmental environmental JJ cord-345339-kyboibtq 36 10 factor factor NN cord-345339-kyboibtq 36 11 in in IN cord-345339-kyboibtq 36 12 MS MS NNP cord-345339-kyboibtq 36 13 . . . cord-345339-kyboibtq 37 1 For for IN cord-345339-kyboibtq 37 2 example example NN cord-345339-kyboibtq 37 3 , , , cord-345339-kyboibtq 37 4 disease disease NN cord-345339-kyboibtq 37 5 distribution distribution NN cord-345339-kyboibtq 37 6 in in IN cord-345339-kyboibtq 37 7 different different JJ cord-345339-kyboibtq 37 8 geographic geographic JJ cord-345339-kyboibtq 37 9 regions region NNS cord-345339-kyboibtq 37 10 can can MD cord-345339-kyboibtq 37 11 be be VB cord-345339-kyboibtq 37 12 classified classify VBN cord-345339-kyboibtq 37 13 according accord VBG cord-345339-kyboibtq 37 14 to to IN cord-345339-kyboibtq 37 15 climate climate NN cord-345339-kyboibtq 37 16 [ [ -LRB- cord-345339-kyboibtq 37 17 5• 5• CD cord-345339-kyboibtq 37 18 ] ] -RRB- cord-345339-kyboibtq 37 19 . . . cord-345339-kyboibtq 38 1 Although although IN cord-345339-kyboibtq 38 2 differences difference NNS cord-345339-kyboibtq 38 3 in in IN cord-345339-kyboibtq 38 4 quality quality NN cord-345339-kyboibtq 38 5 of of IN cord-345339-kyboibtq 38 6 healthcare healthcare NN cord-345339-kyboibtq 38 7 systems system NNS cord-345339-kyboibtq 38 8 and and CC cord-345339-kyboibtq 38 9 recording record VBG cord-345339-kyboibtq 38 10 in in IN cord-345339-kyboibtq 38 11 different different JJ cord-345339-kyboibtq 38 12 countries country NNS cord-345339-kyboibtq 38 13 may may MD cord-345339-kyboibtq 38 14 temper temper VB cord-345339-kyboibtq 38 15 this this DT cord-345339-kyboibtq 38 16 finding finding NN cord-345339-kyboibtq 38 17 , , , cord-345339-kyboibtq 38 18 it -PRON- PRP cord-345339-kyboibtq 38 19 seems seem VBZ cord-345339-kyboibtq 38 20 that that IN cord-345339-kyboibtq 38 21 there there EX cord-345339-kyboibtq 38 22 is be VBZ cord-345339-kyboibtq 38 23 a a DT cord-345339-kyboibtq 38 24 high high JJ cord-345339-kyboibtq 38 25 prevalence prevalence NN cord-345339-kyboibtq 38 26 ( ( -LRB- cord-345339-kyboibtq 38 27 or or CC cord-345339-kyboibtq 38 28 risk risk NN cord-345339-kyboibtq 38 29 ) ) -RRB- cord-345339-kyboibtq 38 30 in in IN cord-345339-kyboibtq 38 31 temperate temperate JJ cord-345339-kyboibtq 38 32 countries country NNS cord-345339-kyboibtq 38 33 ( ( -LRB- cord-345339-kyboibtq 38 34 northern northern JJ cord-345339-kyboibtq 38 35 Europe Europe NNP cord-345339-kyboibtq 38 36 , , , cord-345339-kyboibtq 38 37 United United NNP cord-345339-kyboibtq 38 38 States States NNP cord-345339-kyboibtq 38 39 , , , cord-345339-kyboibtq 38 40 Canada Canada NNP cord-345339-kyboibtq 38 41 , , , cord-345339-kyboibtq 38 42 southern southern JJ cord-345339-kyboibtq 38 43 Australia Australia NNP cord-345339-kyboibtq 38 44 , , , cord-345339-kyboibtq 38 45 and and CC cord-345339-kyboibtq 38 46 New New NNP cord-345339-kyboibtq 38 47 Zealand Zealand NNP cord-345339-kyboibtq 38 48 ) ) -RRB- cord-345339-kyboibtq 38 49 , , , cord-345339-kyboibtq 38 50 a a DT cord-345339-kyboibtq 38 51 low low JJ cord-345339-kyboibtq 38 52 prevalence prevalence NN cord-345339-kyboibtq 38 53 in in IN cord-345339-kyboibtq 38 54 warm warm JJ cord-345339-kyboibtq 38 55 , , , cord-345339-kyboibtq 38 56 equatorial equatorial JJ cord-345339-kyboibtq 38 57 regions region NNS cord-345339-kyboibtq 38 58 ( ( -LRB- cord-345339-kyboibtq 38 59 the the DT cord-345339-kyboibtq 38 60 Caribbean Caribbean NNP cord-345339-kyboibtq 38 61 , , , cord-345339-kyboibtq 38 62 Mexico Mexico NNP cord-345339-kyboibtq 38 63 ) ) -RRB- cord-345339-kyboibtq 38 64 and and CC cord-345339-kyboibtq 38 65 a a DT cord-345339-kyboibtq 38 66 medium medium JJ cord-345339-kyboibtq 38 67 prevalence prevalence NN cord-345339-kyboibtq 38 68 in in IN cord-345339-kyboibtq 38 69 between between IN cord-345339-kyboibtq 38 70 ( ( -LRB- cord-345339-kyboibtq 38 71 southern southern JJ cord-345339-kyboibtq 38 72 Europe Europe NNP cord-345339-kyboibtq 38 73 ) ) -RRB- cord-345339-kyboibtq 38 74 . . . cord-345339-kyboibtq 39 1 Migration migration NN cord-345339-kyboibtq 39 2 might may MD cord-345339-kyboibtq 39 3 also also RB cord-345339-kyboibtq 39 4 induce induce VB cord-345339-kyboibtq 39 5 epidemics epidemic NNS cord-345339-kyboibtq 39 6 . . . cord-345339-kyboibtq 40 1 Probably probably RB cord-345339-kyboibtq 40 2 the the DT cord-345339-kyboibtq 40 3 best well RBS cord-345339-kyboibtq 40 4 - - HYPH cord-345339-kyboibtq 40 5 studied study VBN cord-345339-kyboibtq 40 6 example example NN cord-345339-kyboibtq 40 7 is be VBZ cord-345339-kyboibtq 40 8 the the DT cord-345339-kyboibtq 40 9 outbreak outbreak NN cord-345339-kyboibtq 40 10 of of IN cord-345339-kyboibtq 40 11 an an DT cord-345339-kyboibtq 40 12 MS MS NNP cord-345339-kyboibtq 40 13 epidemic epidemic NN cord-345339-kyboibtq 40 14 in in IN cord-345339-kyboibtq 40 15 the the DT cord-345339-kyboibtq 40 16 Faroe Faroe NNP cord-345339-kyboibtq 40 17 Islands Islands NNPS cord-345339-kyboibtq 40 18 following follow VBG cord-345339-kyboibtq 40 19 stationing station VBG cord-345339-kyboibtq 40 20 of of IN cord-345339-kyboibtq 40 21 British british JJ cord-345339-kyboibtq 40 22 troops troop NNS cord-345339-kyboibtq 40 23 there there RB cord-345339-kyboibtq 40 24 during during IN cord-345339-kyboibtq 40 25 the the DT cord-345339-kyboibtq 40 26 Second Second NNP cord-345339-kyboibtq 40 27 World World NNP cord-345339-kyboibtq 40 28 War War NNP cord-345339-kyboibtq 40 29 [ [ -LRB- cord-345339-kyboibtq 40 30 6 6 CD cord-345339-kyboibtq 40 31 ] ] -RRB- cord-345339-kyboibtq 40 32 . . . cord-345339-kyboibtq 41 1 Migration migration NN cord-345339-kyboibtq 41 2 studies study NNS cord-345339-kyboibtq 41 3 have have VBP cord-345339-kyboibtq 41 4 also also RB cord-345339-kyboibtq 41 5 suggested suggest VBN cord-345339-kyboibtq 41 6 that that IN cord-345339-kyboibtq 41 7 age age NN cord-345339-kyboibtq 41 8 at at IN cord-345339-kyboibtq 41 9 the the DT cord-345339-kyboibtq 41 10 time time NN cord-345339-kyboibtq 41 11 of of IN cord-345339-kyboibtq 41 12 migration migration NN cord-345339-kyboibtq 41 13 is be VBZ cord-345339-kyboibtq 41 14 important important JJ cord-345339-kyboibtq 41 15 . . . cord-345339-kyboibtq 42 1 In in IN cord-345339-kyboibtq 42 2 many many JJ cord-345339-kyboibtq 42 3 instances instance NNS cord-345339-kyboibtq 42 4 , , , cord-345339-kyboibtq 42 5 when when WRB cord-345339-kyboibtq 42 6 individuals individual NNS cord-345339-kyboibtq 42 7 migrate migrate VBP cord-345339-kyboibtq 42 8 prior prior RB cord-345339-kyboibtq 42 9 to to IN cord-345339-kyboibtq 42 10 15 15 CD cord-345339-kyboibtq 42 11 years year NNS cord-345339-kyboibtq 42 12 of of IN cord-345339-kyboibtq 42 13 age age NN cord-345339-kyboibtq 42 14 , , , cord-345339-kyboibtq 42 15 they -PRON- PRP cord-345339-kyboibtq 42 16 exhibit exhibit VBP cord-345339-kyboibtq 42 17 the the DT cord-345339-kyboibtq 42 18 prevalence prevalence NN cord-345339-kyboibtq 42 19 of of IN cord-345339-kyboibtq 42 20 their -PRON- PRP$ cord-345339-kyboibtq 42 21 new new JJ cord-345339-kyboibtq 42 22 home home NN cord-345339-kyboibtq 42 23 . . . cord-345339-kyboibtq 43 1 If if IN cord-345339-kyboibtq 43 2 they -PRON- PRP cord-345339-kyboibtq 43 3 migrate migrate VBP cord-345339-kyboibtq 43 4 at at IN cord-345339-kyboibtq 43 5 a a DT cord-345339-kyboibtq 43 6 later later JJ cord-345339-kyboibtq 43 7 age age NN cord-345339-kyboibtq 43 8 , , , cord-345339-kyboibtq 43 9 they -PRON- PRP cord-345339-kyboibtq 43 10 retain retain VBP cord-345339-kyboibtq 43 11 the the DT cord-345339-kyboibtq 43 12 disease disease NN cord-345339-kyboibtq 43 13 prevalence prevalence NN cord-345339-kyboibtq 43 14 of of IN cord-345339-kyboibtq 43 15 their -PRON- PRP$ cord-345339-kyboibtq 43 16 native native JJ cord-345339-kyboibtq 43 17 country country NN cord-345339-kyboibtq 43 18 . . . cord-345339-kyboibtq 44 1 This this DT cord-345339-kyboibtq 44 2 has have VBZ cord-345339-kyboibtq 44 3 been be VBN cord-345339-kyboibtq 44 4 used use VBN cord-345339-kyboibtq 44 5 to to TO cord-345339-kyboibtq 44 6 argue argue VB cord-345339-kyboibtq 44 7 for for IN cord-345339-kyboibtq 44 8 the the DT cord-345339-kyboibtq 44 9 presence presence NN cord-345339-kyboibtq 44 10 of of IN cord-345339-kyboibtq 44 11 an an DT cord-345339-kyboibtq 44 12 infectious infectious JJ cord-345339-kyboibtq 44 13 factor factor NN cord-345339-kyboibtq 44 14 , , , cord-345339-kyboibtq 44 15 because because IN cord-345339-kyboibtq 44 16 there there EX cord-345339-kyboibtq 44 17 are be VBP cord-345339-kyboibtq 44 18 examples example NNS cord-345339-kyboibtq 44 19 for for IN cord-345339-kyboibtq 44 20 the the DT cord-345339-kyboibtq 44 21 critical critical JJ cord-345339-kyboibtq 44 22 role role NN cord-345339-kyboibtq 44 23 of of IN cord-345339-kyboibtq 44 24 the the DT cord-345339-kyboibtq 44 25 timing timing NN cord-345339-kyboibtq 44 26 of of IN cord-345339-kyboibtq 44 27 primary primary JJ cord-345339-kyboibtq 44 28 infection infection NN cord-345339-kyboibtq 44 29 in in IN cord-345339-kyboibtq 44 30 induction induction NN cord-345339-kyboibtq 44 31 of of IN cord-345339-kyboibtq 44 32 an an DT cord-345339-kyboibtq 44 33 infectious infectious JJ cord-345339-kyboibtq 44 34 CNS CNS NNP cord-345339-kyboibtq 44 35 disorder disorder NN cord-345339-kyboibtq 44 36 [ [ -LRB- cord-345339-kyboibtq 44 37 7 7 CD cord-345339-kyboibtq 44 38 ] ] -RRB- cord-345339-kyboibtq 44 39 . . . cord-345339-kyboibtq 45 1 Anecdotal anecdotal JJ cord-345339-kyboibtq 45 2 evidence evidence NN cord-345339-kyboibtq 45 3 of of IN cord-345339-kyboibtq 45 4 occurrence occurrence NN cord-345339-kyboibtq 45 5 of of IN cord-345339-kyboibtq 45 6 MS MS NNP cord-345339-kyboibtq 45 7 in in IN cord-345339-kyboibtq 45 8 families family NNS cord-345339-kyboibtq 45 9 has have VBZ cord-345339-kyboibtq 45 10 been be VBN cord-345339-kyboibtq 45 11 noted note VBN cord-345339-kyboibtq 45 12 for for IN cord-345339-kyboibtq 45 13 many many JJ cord-345339-kyboibtq 45 14 years year NNS cord-345339-kyboibtq 45 15 [ [ -LRB- cord-345339-kyboibtq 45 16 8 8 CD cord-345339-kyboibtq 45 17 ] ] -RRB- cord-345339-kyboibtq 45 18 . . . cord-345339-kyboibtq 46 1 There there EX cord-345339-kyboibtq 46 2 are be VBP cord-345339-kyboibtq 46 3 few few JJ cord-345339-kyboibtq 46 4 reports report NNS cord-345339-kyboibtq 46 5 of of IN cord-345339-kyboibtq 46 6 conjugal conjugal JJ cord-345339-kyboibtq 46 7 MS MS NNP cord-345339-kyboibtq 46 8 [ [ -LRB- cord-345339-kyboibtq 46 9 9 9 CD cord-345339-kyboibtq 46 10 ] ] -RRB- cord-345339-kyboibtq 46 11 and and CC cord-345339-kyboibtq 46 12 of of IN cord-345339-kyboibtq 46 13 MS MS NNP cord-345339-kyboibtq 46 14 diagnosed diagnose VBN cord-345339-kyboibtq 46 15 in in IN cord-345339-kyboibtq 46 16 children child NNS cord-345339-kyboibtq 46 17 of of IN cord-345339-kyboibtq 46 18 affected affected JJ cord-345339-kyboibtq 46 19 parents parent NNS cord-345339-kyboibtq 46 20 [ [ -LRB- cord-345339-kyboibtq 46 21 10 10 CD cord-345339-kyboibtq 46 22 ] ] -RRB- cord-345339-kyboibtq 46 23 , , , cord-345339-kyboibtq 46 24 but but CC cord-345339-kyboibtq 46 25 not not RB cord-345339-kyboibtq 46 26 enough enough JJ cord-345339-kyboibtq 46 27 to to TO cord-345339-kyboibtq 46 28 enable enable VB cord-345339-kyboibtq 46 29 statistical statistical JJ cord-345339-kyboibtq 46 30 analysis analysis NN cord-345339-kyboibtq 46 31 . . . cord-345339-kyboibtq 47 1 Whether whether IN cord-345339-kyboibtq 47 2 these these DT cord-345339-kyboibtq 47 3 reports report NNS cord-345339-kyboibtq 47 4 , , , cord-345339-kyboibtq 47 5 together together RB cord-345339-kyboibtq 47 6 with with IN cord-345339-kyboibtq 47 7 other other JJ cord-345339-kyboibtq 47 8 documentation documentation NN cord-345339-kyboibtq 47 9 of of IN cord-345339-kyboibtq 47 10 MS MS NNP cord-345339-kyboibtq 47 11 affecting affect VBG cord-345339-kyboibtq 47 12 members member NNS cord-345339-kyboibtq 47 13 of of IN cord-345339-kyboibtq 47 14 the the DT cord-345339-kyboibtq 47 15 same same JJ cord-345339-kyboibtq 47 16 community community NN cord-345339-kyboibtq 47 17 [ [ -LRB- cord-345339-kyboibtq 47 18 11 11 CD cord-345339-kyboibtq 47 19 ] ] -RRB- cord-345339-kyboibtq 47 20 , , , cord-345339-kyboibtq 47 21 those those DT cord-345339-kyboibtq 47 22 who who WP cord-345339-kyboibtq 47 23 share share VBP cord-345339-kyboibtq 47 24 a a DT cord-345339-kyboibtq 47 25 profession profession NN cord-345339-kyboibtq 47 26 , , , cord-345339-kyboibtq 47 27 a a DT cord-345339-kyboibtq 47 28 work work NN cord-345339-kyboibtq 47 29 place place NN cord-345339-kyboibtq 47 30 , , , cord-345339-kyboibtq 47 31 or or CC cord-345339-kyboibtq 47 32 a a DT cord-345339-kyboibtq 47 33 residence residence NN cord-345339-kyboibtq 47 34 are be VBP cord-345339-kyboibtq 47 35 more more JJR cord-345339-kyboibtq 47 36 than than IN cord-345339-kyboibtq 47 37 just just RB cord-345339-kyboibtq 47 38 coincidental coincidental JJ cord-345339-kyboibtq 47 39 anecdotes anecdote NNS cord-345339-kyboibtq 47 40 is be VBZ cord-345339-kyboibtq 47 41 not not RB cord-345339-kyboibtq 47 42 settled settle VBN cord-345339-kyboibtq 47 43 . . . cord-345339-kyboibtq 48 1 With with IN cord-345339-kyboibtq 48 2 no no DT cord-345339-kyboibtq 48 3 true true JJ cord-345339-kyboibtq 48 4 understanding understanding NN cord-345339-kyboibtq 48 5 of of IN cord-345339-kyboibtq 48 6 the the DT cord-345339-kyboibtq 48 7 cause cause NN cord-345339-kyboibtq 48 8 of of IN cord-345339-kyboibtq 48 9 MS MS NNP cord-345339-kyboibtq 48 10 , , , cord-345339-kyboibtq 48 11 the the DT cord-345339-kyboibtq 48 12 animal animal NN cord-345339-kyboibtq 48 13 demyelinating demyelinate VBG cord-345339-kyboibtq 48 14 disease disease NN cord-345339-kyboibtq 48 15 models model NNS cord-345339-kyboibtq 48 16 abound abound VBP cord-345339-kyboibtq 48 17 . . . cord-345339-kyboibtq 49 1 There there EX cord-345339-kyboibtq 49 2 is be VBZ cord-345339-kyboibtq 49 3 quite quite PDT cord-345339-kyboibtq 49 4 a a DT cord-345339-kyboibtq 49 5 spectrum spectrum NN cord-345339-kyboibtq 49 6 of of IN cord-345339-kyboibtq 49 7 viruses virus NNS cord-345339-kyboibtq 49 8 that that WDT cord-345339-kyboibtq 49 9 can can MD cord-345339-kyboibtq 49 10 produce produce VB cord-345339-kyboibtq 49 11 acute acute JJ cord-345339-kyboibtq 49 12 and and CC cord-345339-kyboibtq 49 13 chronic chronic JJ cord-345339-kyboibtq 49 14 demyelinating demyelinating JJ cord-345339-kyboibtq 49 15 conditions condition NNS cord-345339-kyboibtq 49 16 in in IN cord-345339-kyboibtq 49 17 a a DT cord-345339-kyboibtq 49 18 variety variety NN cord-345339-kyboibtq 49 19 of of IN cord-345339-kyboibtq 49 20 experimental experimental JJ cord-345339-kyboibtq 49 21 animals animal NNS cord-345339-kyboibtq 49 22 [ [ -LRB- cord-345339-kyboibtq 49 23 12 12 CD cord-345339-kyboibtq 49 24 ] ] -RRB- cord-345339-kyboibtq 49 25 . . . cord-345339-kyboibtq 50 1 These these DT cord-345339-kyboibtq 50 2 include include VBP cord-345339-kyboibtq 50 3 DNA dna NN cord-345339-kyboibtq 50 4 viruses virus NNS cord-345339-kyboibtq 50 5 such such JJ cord-345339-kyboibtq 50 6 as as IN cord-345339-kyboibtq 50 7 the the DT cord-345339-kyboibtq 50 8 papova papova NNP cord-345339-kyboibtq 50 9 virus virus NN cord-345339-kyboibtq 51 1 SV40 SV40 NNP cord-345339-kyboibtq 51 2 ( ( -LRB- cord-345339-kyboibtq 51 3 rhesus rhesu NNS cord-345339-kyboibtq 51 4 monkeys monkey NNS cord-345339-kyboibtq 51 5 ) ) -RRB- cord-345339-kyboibtq 51 6 and and CC cord-345339-kyboibtq 52 1 herpes herpes NNP cord-345339-kyboibtq 52 2 simplex simplex NNP cord-345339-kyboibtq 52 3 virus virus NN cord-345339-kyboibtq 52 4 type type NN cord-345339-kyboibtq 52 5 1 1 CD cord-345339-kyboibtq 52 6 ( ( -LRB- cord-345339-kyboibtq 52 7 HSV-1 HSV-1 NNP cord-345339-kyboibtq 52 8 ) ) -RRB- cord-345339-kyboibtq 52 9 and and CC cord-345339-kyboibtq 52 10 2 2 LS cord-345339-kyboibtq 52 11 ( ( -LRB- cord-345339-kyboibtq 52 12 in in IN cord-345339-kyboibtq 52 13 mice mouse NNS cord-345339-kyboibtq 52 14 ) ) -RRB- cord-345339-kyboibtq 52 15 , , , cord-345339-kyboibtq 52 16 RNA RNA NNP cord-345339-kyboibtq 52 17 viruses virus NNS cord-345339-kyboibtq 52 18 such such JJ cord-345339-kyboibtq 52 19 as as IN cord-345339-kyboibtq 52 20 canine canine JJ cord-345339-kyboibtq 52 21 distemper distemper NN cord-345339-kyboibtq 52 22 virus virus NN cord-345339-kyboibtq 52 23 ( ( -LRB- cord-345339-kyboibtq 52 24 mice mouse NNS cord-345339-kyboibtq 52 25 and and CC cord-345339-kyboibtq 52 26 hamsters hamster NNS cord-345339-kyboibtq 52 27 ) ) -RRB- cord-345339-kyboibtq 52 28 , , , cord-345339-kyboibtq 52 29 several several JJ cord-345339-kyboibtq 52 30 corona corona NN cord-345339-kyboibtq 52 31 virus virus NN cord-345339-kyboibtq 52 32 models model NNS cord-345339-kyboibtq 52 33 in in IN cord-345339-kyboibtq 52 34 mice mouse NNS cord-345339-kyboibtq 52 35 and and CC cord-345339-kyboibtq 52 36 monkeys monkey NNS cord-345339-kyboibtq 52 37 , , , cord-345339-kyboibtq 52 38 the the DT cord-345339-kyboibtq 52 39 murine murine JJ cord-345339-kyboibtq 52 40 picorna picorna NNP cord-345339-kyboibtq 52 41 Theiler Theiler NNP cord-345339-kyboibtq 52 42 's 's POS cord-345339-kyboibtq 52 43 virus virus NN cord-345339-kyboibtq 52 44 , , , cord-345339-kyboibtq 52 45 and and CC cord-345339-kyboibtq 52 46 retroviruses retrovirus NNS cord-345339-kyboibtq 52 47 such such JJ cord-345339-kyboibtq 52 48 as as IN cord-345339-kyboibtq 52 49 visna visna NNP cord-345339-kyboibtq 52 50 virus virus NN cord-345339-kyboibtq 52 51 in in IN cord-345339-kyboibtq 52 52 sheep sheep NN cord-345339-kyboibtq 52 53 . . . cord-345339-kyboibtq 53 1 These these DT cord-345339-kyboibtq 53 2 models model NNS cord-345339-kyboibtq 53 3 prove prove VBP cord-345339-kyboibtq 53 4 the the DT cord-345339-kyboibtq 53 5 concept concept NN cord-345339-kyboibtq 53 6 that that IN cord-345339-kyboibtq 53 7 viruses virus NNS cord-345339-kyboibtq 53 8 can can MD cord-345339-kyboibtq 53 9 induce induce VB cord-345339-kyboibtq 53 10 demyelination demyelination NN cord-345339-kyboibtq 53 11 . . . cord-345339-kyboibtq 54 1 Interferons interferon NNS cord-345339-kyboibtq 54 2 for for IN cord-345339-kyboibtq 54 3 the the DT cord-345339-kyboibtq 54 4 treatment treatment NN cord-345339-kyboibtq 54 5 of of IN cord-345339-kyboibtq 54 6 multiple multiple JJ cord-345339-kyboibtq 54 7 sclerosis sclerosis NN cord-345339-kyboibtq 55 1 As as IN cord-345339-kyboibtq 55 2 of of IN cord-345339-kyboibtq 55 3 today today NN cord-345339-kyboibtq 55 4 , , , cord-345339-kyboibtq 55 5 three three CD cord-345339-kyboibtq 55 6 β β NN cord-345339-kyboibtq 55 7 - - HYPH cord-345339-kyboibtq 55 8 interferon interferon JJ cord-345339-kyboibtq 55 9 preparations preparation NNS cord-345339-kyboibtq 55 10 are be VBP cord-345339-kyboibtq 55 11 licensed license VBN cord-345339-kyboibtq 55 12 for for IN cord-345339-kyboibtq 55 13 the the DT cord-345339-kyboibtq 55 14 treatment treatment NN cord-345339-kyboibtq 55 15 of of IN cord-345339-kyboibtq 55 16 MS MS NNP cord-345339-kyboibtq 55 17 . . . cord-345339-kyboibtq 56 1 They -PRON- PRP cord-345339-kyboibtq 56 2 were be VBD cord-345339-kyboibtq 56 3 shown show VBN cord-345339-kyboibtq 56 4 to to TO cord-345339-kyboibtq 56 5 have have VB cord-345339-kyboibtq 56 6 a a DT cord-345339-kyboibtq 56 7 moderate moderate JJ cord-345339-kyboibtq 56 8 effect effect NN cord-345339-kyboibtq 56 9 upon upon IN cord-345339-kyboibtq 56 10 disease disease NN cord-345339-kyboibtq 56 11 relapse relapse NN cord-345339-kyboibtq 56 12 rate rate NN cord-345339-kyboibtq 56 13 and and CC cord-345339-kyboibtq 56 14 progression progression NN cord-345339-kyboibtq 56 15 of of IN cord-345339-kyboibtq 56 16 disability disability NN cord-345339-kyboibtq 56 17 [ [ -LRB- cord-345339-kyboibtq 56 18 13 13 CD cord-345339-kyboibtq 56 19 ] ] -RRB- cord-345339-kyboibtq 57 1 [ [ -LRB- cord-345339-kyboibtq 57 2 14 14 CD cord-345339-kyboibtq 57 3 ] ] -RRB- cord-345339-kyboibtq 57 4 [ [ -LRB- cord-345339-kyboibtq 57 5 15 15 CD cord-345339-kyboibtq 57 6 ] ] -RRB- cord-345339-kyboibtq 57 7 . . . cord-345339-kyboibtq 58 1 Interferons interferon NNS cord-345339-kyboibtq 58 2 are be VBP cord-345339-kyboibtq 58 3 naturally naturally RB cord-345339-kyboibtq 58 4 occurring occur VBG cord-345339-kyboibtq 58 5 species species NN cord-345339-kyboibtq 58 6 - - HYPH cord-345339-kyboibtq 58 7 specific specific JJ cord-345339-kyboibtq 58 8 glycoproteins glycoprotein NNS cord-345339-kyboibtq 58 9 that that WDT cord-345339-kyboibtq 58 10 were be VBD cord-345339-kyboibtq 58 11 first first RB cord-345339-kyboibtq 58 12 discovered discover VBN cord-345339-kyboibtq 58 13 in in IN cord-345339-kyboibtq 58 14 1957 1957 CD cord-345339-kyboibtq 58 15 because because IN cord-345339-kyboibtq 58 16 of of IN cord-345339-kyboibtq 58 17 their -PRON- PRP$ cord-345339-kyboibtq 58 18 antiviral antiviral JJ cord-345339-kyboibtq 58 19 activity activity NN cord-345339-kyboibtq 58 20 , , , cord-345339-kyboibtq 58 21 but but CC cord-345339-kyboibtq 58 22 they -PRON- PRP cord-345339-kyboibtq 58 23 also also RB cord-345339-kyboibtq 58 24 possess possess VBP cord-345339-kyboibtq 58 25 a a DT cord-345339-kyboibtq 58 26 variety variety NN cord-345339-kyboibtq 58 27 of of IN cord-345339-kyboibtq 58 28 other other JJ cord-345339-kyboibtq 58 29 biologic biologic JJ cord-345339-kyboibtq 58 30 actions action NNS cord-345339-kyboibtq 58 31 . . . cord-345339-kyboibtq 59 1 They -PRON- PRP cord-345339-kyboibtq 59 2 belong belong VBP cord-345339-kyboibtq 59 3 to to IN cord-345339-kyboibtq 59 4 the the DT cord-345339-kyboibtq 59 5 ever ever RB cord-345339-kyboibtq 59 6 - - HYPH cord-345339-kyboibtq 59 7 growing grow VBG cord-345339-kyboibtq 59 8 group group NN cord-345339-kyboibtq 59 9 of of IN cord-345339-kyboibtq 59 10 cytokines cytokine NNS cord-345339-kyboibtq 59 11 that that WDT cord-345339-kyboibtq 59 12 are be VBP cord-345339-kyboibtq 59 13 capable capable JJ cord-345339-kyboibtq 59 14 of of IN cord-345339-kyboibtq 59 15 modulating modulate VBG cord-345339-kyboibtq 59 16 the the DT cord-345339-kyboibtq 59 17 immune immune JJ cord-345339-kyboibtq 59 18 system system NN cord-345339-kyboibtq 59 19 . . . cord-345339-kyboibtq 60 1 Nevertheless nevertheless RB cord-345339-kyboibtq 60 2 , , , cord-345339-kyboibtq 60 3 one one CD cord-345339-kyboibtq 60 4 of of IN cord-345339-kyboibtq 60 5 their -PRON- PRP$ cord-345339-kyboibtq 60 6 major major JJ cord-345339-kyboibtq 60 7 functions function NNS cord-345339-kyboibtq 60 8 is be VBZ cord-345339-kyboibtq 60 9 to to TO cord-345339-kyboibtq 60 10 combat combat VB cord-345339-kyboibtq 60 11 viral viral JJ cord-345339-kyboibtq 60 12 infections infection NNS cord-345339-kyboibtq 60 13 . . . cord-345339-kyboibtq 61 1 They -PRON- PRP cord-345339-kyboibtq 61 2 are be VBP cord-345339-kyboibtq 61 3 in in IN cord-345339-kyboibtq 61 4 clinical clinical JJ cord-345339-kyboibtq 61 5 use use NN cord-345339-kyboibtq 61 6 for for IN cord-345339-kyboibtq 61 7 treatment treatment NN cord-345339-kyboibtq 61 8 of of IN cord-345339-kyboibtq 61 9 conditions condition NNS cord-345339-kyboibtq 61 10 such such JJ cord-345339-kyboibtq 61 11 as as IN cord-345339-kyboibtq 61 12 infections infection NNS cord-345339-kyboibtq 61 13 due due JJ cord-345339-kyboibtq 61 14 to to IN cord-345339-kyboibtq 61 15 hepatitis hepatitis NNP cord-345339-kyboibtq 61 16 B B NNP cord-345339-kyboibtq 61 17 and and CC cord-345339-kyboibtq 61 18 C c NN cord-345339-kyboibtq 61 19 viruses virus NNS cord-345339-kyboibtq 61 20 , , , cord-345339-kyboibtq 61 21 and and CC cord-345339-kyboibtq 61 22 genital genital JJ cord-345339-kyboibtq 61 23 warts wart NNS cord-345339-kyboibtq 61 24 caused cause VBN cord-345339-kyboibtq 61 25 by by IN cord-345339-kyboibtq 61 26 papillomavirus papillomavirus NN cord-345339-kyboibtq 61 27 . . . cord-345339-kyboibtq 62 1 Although although IN cord-345339-kyboibtq 62 2 it -PRON- PRP cord-345339-kyboibtq 62 3 has have VBZ cord-345339-kyboibtq 62 4 been be VBN cord-345339-kyboibtq 62 5 argued argue VBN cord-345339-kyboibtq 62 6 that that IN cord-345339-kyboibtq 62 7 the the DT cord-345339-kyboibtq 62 8 β β NN cord-345339-kyboibtq 62 9 - - HYPH cord-345339-kyboibtq 62 10 interferons interferon NNS cord-345339-kyboibtq 62 11 ' ' POS cord-345339-kyboibtq 62 12 effect effect NN cord-345339-kyboibtq 62 13 upon upon IN cord-345339-kyboibtq 62 14 MS MS NNP cord-345339-kyboibtq 62 15 is be VBZ cord-345339-kyboibtq 62 16 immunomodulatory immunomodulatory NNP cord-345339-kyboibtq 62 17 , , , cord-345339-kyboibtq 62 18 the the DT cord-345339-kyboibtq 62 19 possibility possibility NN cord-345339-kyboibtq 62 20 that that IN cord-345339-kyboibtq 62 21 their -PRON- PRP$ cord-345339-kyboibtq 62 22 impact impact NN cord-345339-kyboibtq 62 23 is be VBZ cord-345339-kyboibtq 62 24 directly directly RB cord-345339-kyboibtq 62 25 antiviral antiviral JJ cord-345339-kyboibtq 62 26 is be VBZ cord-345339-kyboibtq 62 27 just just RB cord-345339-kyboibtq 62 28 as as RB cord-345339-kyboibtq 62 29 likely likely JJ cord-345339-kyboibtq 62 30 . . . cord-345339-kyboibtq 63 1 Viruses virus NNS cord-345339-kyboibtq 63 2 can can MD cord-345339-kyboibtq 63 3 cause cause VB cord-345339-kyboibtq 63 4 a a DT cord-345339-kyboibtq 63 5 variety variety NN cord-345339-kyboibtq 63 6 of of IN cord-345339-kyboibtq 63 7 naturally naturally RB cord-345339-kyboibtq 63 8 occurring occur VBG cord-345339-kyboibtq 63 9 human human JJ cord-345339-kyboibtq 63 10 CNS CNS NNP cord-345339-kyboibtq 63 11 demyelinating demyelinate VBG cord-345339-kyboibtq 63 12 diseases disease NNS cord-345339-kyboibtq 63 13 . . . cord-345339-kyboibtq 64 1 Infective Infective NNP cord-345339-kyboibtq 64 2 and and CC cord-345339-kyboibtq 64 3 postinfective postinfective JJ cord-345339-kyboibtq 64 4 conditions condition NNS cord-345339-kyboibtq 64 5 have have VBP cord-345339-kyboibtq 64 6 been be VBN cord-345339-kyboibtq 64 7 noted note VBN cord-345339-kyboibtq 64 8 : : : cord-345339-kyboibtq 64 9 progressive progressive JJ cord-345339-kyboibtq 64 10 multifocal multifocal JJ cord-345339-kyboibtq 64 11 leukoencephalopathy leukoencephalopathy NNS cord-345339-kyboibtq 64 12 ( ( -LRB- cord-345339-kyboibtq 64 13 PML PML NNP cord-345339-kyboibtq 64 14 ) ) -RRB- cord-345339-kyboibtq 64 15 and and CC cord-345339-kyboibtq 64 16 tropical tropical JJ cord-345339-kyboibtq 64 17 spastic spastic JJ cord-345339-kyboibtq 64 18 paraparesis paraparesis NN cord-345339-kyboibtq 64 19 are be VBP cord-345339-kyboibtq 64 20 examples example NNS cord-345339-kyboibtq 64 21 of of IN cord-345339-kyboibtq 64 22 the the DT cord-345339-kyboibtq 64 23 first first JJ cord-345339-kyboibtq 64 24 , , , cord-345339-kyboibtq 64 25 whereas whereas IN cord-345339-kyboibtq 64 26 postinfectious postinfectious NNP cord-345339-kyboibtq 64 27 encephalomyelitis encephalomyelitis NN cord-345339-kyboibtq 64 28 occurs occur VBZ cord-345339-kyboibtq 64 29 following follow VBG cord-345339-kyboibtq 64 30 diverse diverse JJ cord-345339-kyboibtq 64 31 infections infection NNS cord-345339-kyboibtq 64 32 . . . cord-345339-kyboibtq 65 1 Although although IN cord-345339-kyboibtq 65 2 these these DT cord-345339-kyboibtq 65 3 disorders disorder NNS cord-345339-kyboibtq 65 4 are be VBP cord-345339-kyboibtq 65 5 clinically clinically RB cord-345339-kyboibtq 65 6 distinct distinct JJ cord-345339-kyboibtq 65 7 from from IN cord-345339-kyboibtq 65 8 MS MS NNP cord-345339-kyboibtq 65 9 , , , cord-345339-kyboibtq 65 10 they -PRON- PRP cord-345339-kyboibtq 65 11 nevertheless nevertheless RB cord-345339-kyboibtq 65 12 suggest suggest VBP cord-345339-kyboibtq 65 13 that that IN cord-345339-kyboibtq 65 14 viruses virus NNS cord-345339-kyboibtq 65 15 are be VBP cord-345339-kyboibtq 65 16 capable capable JJ cord-345339-kyboibtq 65 17 of of IN cord-345339-kyboibtq 65 18 inducing induce VBG cord-345339-kyboibtq 65 19 demyelinating demyelinate VBG cord-345339-kyboibtq 65 20 diseases disease NNS cord-345339-kyboibtq 65 21 in in IN cord-345339-kyboibtq 65 22 the the DT cord-345339-kyboibtq 65 23 human human JJ cord-345339-kyboibtq 65 24 CNS CNS NNP cord-345339-kyboibtq 65 25 . . . cord-345339-kyboibtq 66 1 Cerebrospinal cerebrospinal NN cord-345339-kyboibtq 66 2 fluid fluid NN cord-345339-kyboibtq 67 1 ( ( -LRB- cord-345339-kyboibtq 67 2 CSF CSF NNP cord-345339-kyboibtq 67 3 ) ) -RRB- cord-345339-kyboibtq 67 4 oligoclonal oligoclonal JJ cord-345339-kyboibtq 67 5 bands band NNS cord-345339-kyboibtq 67 6 are be VBP cord-345339-kyboibtq 67 7 present present JJ cord-345339-kyboibtq 67 8 in in IN cord-345339-kyboibtq 67 9 the the DT cord-345339-kyboibtq 67 10 vast vast JJ cord-345339-kyboibtq 67 11 majority majority NN cord-345339-kyboibtq 67 12 of of IN cord-345339-kyboibtq 67 13 MS MS NNP cord-345339-kyboibtq 67 14 patients patient NNS cord-345339-kyboibtq 67 15 . . . cord-345339-kyboibtq 68 1 Although although IN cord-345339-kyboibtq 68 2 attributed attribute VBN cord-345339-kyboibtq 68 3 to to IN cord-345339-kyboibtq 68 4 a a DT cord-345339-kyboibtq 68 5 chronic chronic JJ cord-345339-kyboibtq 68 6 immune immune NN cord-345339-kyboibtq 68 7 - - HYPH cord-345339-kyboibtq 68 8 mediated mediate VBN cord-345339-kyboibtq 68 9 process process NN cord-345339-kyboibtq 68 10 , , , cord-345339-kyboibtq 68 11 CSF CSF NNP cord-345339-kyboibtq 68 12 oligoclonal oligoclonal JJ cord-345339-kyboibtq 68 13 bands band NNS cord-345339-kyboibtq 68 14 are be VBP cord-345339-kyboibtq 68 15 also also RB cord-345339-kyboibtq 68 16 a a DT cord-345339-kyboibtq 68 17 feature feature NN cord-345339-kyboibtq 68 18 of of IN cord-345339-kyboibtq 68 19 chronic chronic JJ cord-345339-kyboibtq 68 20 CNS CNS NNP cord-345339-kyboibtq 68 21 infections infection NNS cord-345339-kyboibtq 68 22 [ [ -LRB- cord-345339-kyboibtq 68 23 16 16 CD cord-345339-kyboibtq 68 24 ] ] -RRB- cord-345339-kyboibtq 68 25 . . . cord-345339-kyboibtq 69 1 In in IN cord-345339-kyboibtq 69 2 view view NN cord-345339-kyboibtq 69 3 of of IN cord-345339-kyboibtq 69 4 the the DT cord-345339-kyboibtq 69 5 current current JJ cord-345339-kyboibtq 69 6 dogma dogma NN cord-345339-kyboibtq 69 7 of of IN cord-345339-kyboibtq 69 8 MS MS NNP cord-345339-kyboibtq 69 9 as as IN cord-345339-kyboibtq 69 10 an an DT cord-345339-kyboibtq 69 11 immune immune NN cord-345339-kyboibtq 69 12 - - HYPH cord-345339-kyboibtq 69 13 mediated mediate VBN cord-345339-kyboibtq 69 14 disorder disorder NN cord-345339-kyboibtq 69 15 , , , cord-345339-kyboibtq 69 16 the the DT cord-345339-kyboibtq 69 17 possibility possibility NN cord-345339-kyboibtq 69 18 that that IN cord-345339-kyboibtq 69 19 the the DT cord-345339-kyboibtq 69 20 disease disease NN cord-345339-kyboibtq 69 21 and/or and/or CC cord-345339-kyboibtq 69 22 its -PRON- PRP$ cord-345339-kyboibtq 69 23 relapses relapse NNS cord-345339-kyboibtq 69 24 are be VBP cord-345339-kyboibtq 69 25 triggered trigger VBN cord-345339-kyboibtq 69 26 by by IN cord-345339-kyboibtq 69 27 infections infection NNS cord-345339-kyboibtq 69 28 , , , cord-345339-kyboibtq 69 29 whereas whereas IN cord-345339-kyboibtq 69 30 the the DT cord-345339-kyboibtq 69 31 eventual eventual JJ cord-345339-kyboibtq 69 32 tissue tissue NN cord-345339-kyboibtq 69 33 damage damage NN cord-345339-kyboibtq 69 34 is be VBZ cord-345339-kyboibtq 69 35 due due JJ cord-345339-kyboibtq 69 36 to to IN cord-345339-kyboibtq 69 37 immune immune JJ cord-345339-kyboibtq 69 38 activation activation NN cord-345339-kyboibtq 69 39 , , , cord-345339-kyboibtq 69 40 might may MD cord-345339-kyboibtq 69 41 be be VB cord-345339-kyboibtq 69 42 more more RBR cord-345339-kyboibtq 69 43 appealing appealing JJ cord-345339-kyboibtq 69 44 than than IN cord-345339-kyboibtq 69 45 the the DT cord-345339-kyboibtq 69 46 concept concept NN cord-345339-kyboibtq 69 47 that that IN cord-345339-kyboibtq 69 48 MS MS NNP cord-345339-kyboibtq 69 49 is be VBZ cord-345339-kyboibtq 69 50 a a DT cord-345339-kyboibtq 69 51 true true JJ cord-345339-kyboibtq 69 52 infective infective JJ cord-345339-kyboibtq 69 53 process process NN cord-345339-kyboibtq 69 54 . . . cord-345339-kyboibtq 70 1 The the DT cord-345339-kyboibtq 70 2 methodology methodology NN cord-345339-kyboibtq 70 3 used use VBD cord-345339-kyboibtq 70 4 to to TO cord-345339-kyboibtq 70 5 examine examine VB cord-345339-kyboibtq 70 6 an an DT cord-345339-kyboibtq 70 7 association association NN cord-345339-kyboibtq 70 8 between between IN cord-345339-kyboibtq 70 9 infection infection NN cord-345339-kyboibtq 70 10 and and CC cord-345339-kyboibtq 70 11 clinical clinical JJ cord-345339-kyboibtq 70 12 diseases disease NNS cord-345339-kyboibtq 70 13 is be VBZ cord-345339-kyboibtq 70 14 both both DT cord-345339-kyboibtq 70 15 epidemiologic epidemiologic JJ cord-345339-kyboibtq 70 16 and and CC cord-345339-kyboibtq 70 17 serologic serologic JJ cord-345339-kyboibtq 70 18 / / SYM cord-345339-kyboibtq 70 19 immunologic immunologic NN cord-345339-kyboibtq 70 20 . . . cord-345339-kyboibtq 71 1 Some some DT cord-345339-kyboibtq 71 2 studies study NNS cord-345339-kyboibtq 71 3 that that WDT cord-345339-kyboibtq 71 4 examined examine VBD cord-345339-kyboibtq 71 5 the the DT cord-345339-kyboibtq 71 6 association association NN cord-345339-kyboibtq 71 7 between between IN cord-345339-kyboibtq 71 8 antecedent antecedent JJ cord-345339-kyboibtq 71 9 infection infection NN cord-345339-kyboibtq 71 10 and and CC cord-345339-kyboibtq 71 11 occurrence occurrence NN cord-345339-kyboibtq 71 12 of of IN cord-345339-kyboibtq 71 13 MS MS NNP cord-345339-kyboibtq 71 14 may may MD cord-345339-kyboibtq 71 15 suggest suggest VB cord-345339-kyboibtq 71 16 a a DT cord-345339-kyboibtq 71 17 sequential sequential JJ cord-345339-kyboibtq 71 18 relationship relationship NN cord-345339-kyboibtq 71 19 . . . cord-345339-kyboibtq 72 1 These these DT cord-345339-kyboibtq 72 2 included include VBD cord-345339-kyboibtq 72 3 unspecified unspecified JJ cord-345339-kyboibtq 72 4 infections infection NNS cord-345339-kyboibtq 72 5 [ [ -LRB- cord-345339-kyboibtq 72 6 17 17 CD cord-345339-kyboibtq 72 7 ] ] -RRB- cord-345339-kyboibtq 72 8 and and CC cord-345339-kyboibtq 72 9 infections infection NNS cord-345339-kyboibtq 72 10 with with IN cord-345339-kyboibtq 72 11 specific specific JJ cord-345339-kyboibtq 72 12 agents agent NNS cord-345339-kyboibtq 72 13 , , , cord-345339-kyboibtq 72 14 such such JJ cord-345339-kyboibtq 72 15 as as IN cord-345339-kyboibtq 72 16 measles measle NNS cord-345339-kyboibtq 72 17 [ [ -LRB- cord-345339-kyboibtq 72 18 18 18 CD cord-345339-kyboibtq 72 19 ] ] -RRB- cord-345339-kyboibtq 72 20 and and CC cord-345339-kyboibtq 72 21 Epstein Epstein NNP cord-345339-kyboibtq 72 22 - - HYPH cord-345339-kyboibtq 72 23 Barr Barr NNP cord-345339-kyboibtq 72 24 virus virus NN cord-345339-kyboibtq 72 25 ( ( -LRB- cord-345339-kyboibtq 72 26 EBV EBV NNP cord-345339-kyboibtq 72 27 ) ) -RRB- cord-345339-kyboibtq 72 28 [ [ -LRB- cord-345339-kyboibtq 72 29 19 19 CD cord-345339-kyboibtq 72 30 ] ] -RRB- cord-345339-kyboibtq 72 31 . . . cord-345339-kyboibtq 73 1 There there EX cord-345339-kyboibtq 73 2 seems seem VBZ cord-345339-kyboibtq 73 3 also also RB cord-345339-kyboibtq 73 4 to to TO cord-345339-kyboibtq 73 5 be be VB cord-345339-kyboibtq 73 6 a a DT cord-345339-kyboibtq 73 7 relationship relationship NN cord-345339-kyboibtq 73 8 between between IN cord-345339-kyboibtq 73 9 an an DT cord-345339-kyboibtq 73 10 infection infection NN cord-345339-kyboibtq 73 11 and and CC cord-345339-kyboibtq 73 12 the the DT cord-345339-kyboibtq 73 13 occurrence occurrence NN cord-345339-kyboibtq 73 14 of of IN cord-345339-kyboibtq 73 15 a a DT cord-345339-kyboibtq 73 16 relapse relapse NN cord-345339-kyboibtq 73 17 in in IN cord-345339-kyboibtq 73 18 a a DT cord-345339-kyboibtq 73 19 setup setup NN cord-345339-kyboibtq 73 20 of of IN cord-345339-kyboibtq 73 21 already already RB cord-345339-kyboibtq 73 22 defined define VBN cord-345339-kyboibtq 73 23 clinical clinical JJ cord-345339-kyboibtq 73 24 MS MS NNP cord-345339-kyboibtq 73 25 [ [ -LRB- cord-345339-kyboibtq 73 26 20 20 CD cord-345339-kyboibtq 73 27 ] ] -RRB- cord-345339-kyboibtq 73 28 . . . cord-345339-kyboibtq 74 1 Approximately approximately RB cord-345339-kyboibtq 74 2 9 9 CD cord-345339-kyboibtq 74 3 % % NN cord-345339-kyboibtq 74 4 of of IN cord-345339-kyboibtq 74 5 infections infection NNS cord-345339-kyboibtq 74 6 were be VBD cord-345339-kyboibtq 74 7 temporally temporally RB cord-345339-kyboibtq 74 8 related relate VBN cord-345339-kyboibtq 74 9 to to IN cord-345339-kyboibtq 74 10 exacerbations exacerbation NNS cord-345339-kyboibtq 74 11 , , , cord-345339-kyboibtq 74 12 whereas whereas IN cord-345339-kyboibtq 74 13 27 27 CD cord-345339-kyboibtq 74 14 % % NN cord-345339-kyboibtq 74 15 of of IN cord-345339-kyboibtq 74 16 exacerbations exacerbation NNS cord-345339-kyboibtq 74 17 followed follow VBD cord-345339-kyboibtq 74 18 infections infection NNS cord-345339-kyboibtq 74 19 . . . cord-345339-kyboibtq 75 1 This this DT cord-345339-kyboibtq 75 2 observation observation NN cord-345339-kyboibtq 75 3 was be VBD cord-345339-kyboibtq 75 4 confirmed confirm VBN cord-345339-kyboibtq 75 5 by by IN cord-345339-kyboibtq 75 6 a a DT cord-345339-kyboibtq 75 7 prospective prospective JJ cord-345339-kyboibtq 75 8 study study NN cord-345339-kyboibtq 75 9 that that WDT cord-345339-kyboibtq 75 10 followed follow VBD cord-345339-kyboibtq 75 11 MS MS NNP cord-345339-kyboibtq 75 12 relapses relapse NNS cord-345339-kyboibtq 75 13 by by IN cord-345339-kyboibtq 75 14 magnetic magnetic JJ cord-345339-kyboibtq 75 15 resonance resonance NN cord-345339-kyboibtq 75 16 imaging imaging NN cord-345339-kyboibtq 75 17 ( ( -LRB- cord-345339-kyboibtq 75 18 MRI MRI NNP cord-345339-kyboibtq 75 19 ) ) -RRB- cord-345339-kyboibtq 75 20 [ [ -LRB- cord-345339-kyboibtq 75 21 21 21 CD cord-345339-kyboibtq 75 22 ] ] -RRB- cord-345339-kyboibtq 75 23 . . . cord-345339-kyboibtq 76 1 MS MS NNP cord-345339-kyboibtq 76 2 relapses relapse NNS cord-345339-kyboibtq 76 3 also also RB cord-345339-kyboibtq 76 4 tended tend VBD cord-345339-kyboibtq 76 5 to to TO cord-345339-kyboibtq 76 6 have have VB cord-345339-kyboibtq 76 7 a a DT cord-345339-kyboibtq 76 8 seasonal seasonal JJ cord-345339-kyboibtq 76 9 increase increase NN cord-345339-kyboibtq 76 10 , , , cord-345339-kyboibtq 76 11 in in IN cord-345339-kyboibtq 76 12 association association NN cord-345339-kyboibtq 76 13 with with IN cord-345339-kyboibtq 76 14 respiratory respiratory JJ cord-345339-kyboibtq 76 15 infections infection NNS cord-345339-kyboibtq 76 16 . . . cord-345339-kyboibtq 77 1 Immunology immunology NN cord-345339-kyboibtq 77 2 / / SYM cord-345339-kyboibtq 77 3 serology serology NN cord-345339-kyboibtq 77 4 can can MD cord-345339-kyboibtq 77 5 serve serve VB cord-345339-kyboibtq 77 6 to to TO cord-345339-kyboibtq 77 7 suggest suggest VB cord-345339-kyboibtq 77 8 both both CC cord-345339-kyboibtq 77 9 an an DT cord-345339-kyboibtq 77 10 ongoing ongoing JJ cord-345339-kyboibtq 77 11 infectious infectious JJ cord-345339-kyboibtq 77 12 process process NN cord-345339-kyboibtq 77 13 and/or and/or CC cord-345339-kyboibtq 77 14 a a DT cord-345339-kyboibtq 77 15 previous previous JJ cord-345339-kyboibtq 77 16 exposure exposure NN cord-345339-kyboibtq 77 17 to to IN cord-345339-kyboibtq 77 18 a a DT cord-345339-kyboibtq 77 19 pathogen pathogen NN cord-345339-kyboibtq 77 20 . . . cord-345339-kyboibtq 78 1 Antiviral antiviral JJ cord-345339-kyboibtq 78 2 antibodies antibody NNS cord-345339-kyboibtq 78 3 were be VBD cord-345339-kyboibtq 78 4 examined examine VBN cord-345339-kyboibtq 78 5 in in IN cord-345339-kyboibtq 78 6 the the DT cord-345339-kyboibtq 78 7 serum serum NN cord-345339-kyboibtq 78 8 and and CC cord-345339-kyboibtq 78 9 the the DT cord-345339-kyboibtq 78 10 CSF CSF NNP cord-345339-kyboibtq 78 11 of of IN cord-345339-kyboibtq 78 12 MS MS NNP cord-345339-kyboibtq 78 13 patients patient NNS cord-345339-kyboibtq 78 14 . . . cord-345339-kyboibtq 79 1 Higher high JJR cord-345339-kyboibtq 79 2 titers titer NNS cord-345339-kyboibtq 79 3 of of IN cord-345339-kyboibtq 79 4 antibodies antibody NNS cord-345339-kyboibtq 79 5 against against IN cord-345339-kyboibtq 79 6 a a DT cord-345339-kyboibtq 79 7 large large JJ cord-345339-kyboibtq 79 8 spectrum spectrum NN cord-345339-kyboibtq 79 9 of of IN cord-345339-kyboibtq 79 10 viruses virus NNS cord-345339-kyboibtq 79 11 were be VBD cord-345339-kyboibtq 79 12 found find VBN cord-345339-kyboibtq 79 13 ( ( -LRB- cord-345339-kyboibtq 79 14 but but CC cord-345339-kyboibtq 79 15 not not RB cord-345339-kyboibtq 79 16 always always RB cord-345339-kyboibtq 79 17 confirmed confirm VBN cord-345339-kyboibtq 79 18 ) ) -RRB- cord-345339-kyboibtq 79 19 in in IN cord-345339-kyboibtq 79 20 MS MS NNP cord-345339-kyboibtq 79 21 patients patient NNS cord-345339-kyboibtq 79 22 when when WRB cord-345339-kyboibtq 79 23 compared compare VBN cord-345339-kyboibtq 79 24 with with IN cord-345339-kyboibtq 79 25 control control NN cord-345339-kyboibtq 79 26 patients patient NNS cord-345339-kyboibtq 79 27 . . . cord-345339-kyboibtq 80 1 The the DT cord-345339-kyboibtq 80 2 list list NN cord-345339-kyboibtq 80 3 [ [ -LRB- cord-345339-kyboibtq 80 4 12 12 CD cord-345339-kyboibtq 80 5 , , , cord-345339-kyboibtq 80 6 22 22 CD cord-345339-kyboibtq 80 7 ] ] -RRB- cord-345339-kyboibtq 80 8 includes include VBZ cord-345339-kyboibtq 80 9 measles measles NN cord-345339-kyboibtq 80 10 , , , cord-345339-kyboibtq 80 11 parainfluenza parainfluenza NNP cord-345339-kyboibtq 80 12 , , , cord-345339-kyboibtq 80 13 influenza influenza NN cord-345339-kyboibtq 80 14 , , , cord-345339-kyboibtq 80 15 varicella varicella NN cord-345339-kyboibtq 80 16 zoster zoster NN cord-345339-kyboibtq 80 17 , , , cord-345339-kyboibtq 80 18 HSV HSV NNP cord-345339-kyboibtq 80 19 , , , cord-345339-kyboibtq 80 20 rubella rubella NN cord-345339-kyboibtq 80 21 , , , cord-345339-kyboibtq 80 22 EBV EBV NNP cord-345339-kyboibtq 80 23 , , , cord-345339-kyboibtq 80 24 mumps mumps NN cord-345339-kyboibtq 80 25 , , , cord-345339-kyboibtq 80 26 human human JJ cord-345339-kyboibtq 80 27 T t NN cord-345339-kyboibtq 80 28 - - HYPH cord-345339-kyboibtq 80 29 cell cell NN cord-345339-kyboibtq 80 30 lymphotropic lymphotropic NNP cord-345339-kyboibtq 80 31 virus virus NN cord-345339-kyboibtq 80 32 ( ( -LRB- cord-345339-kyboibtq 80 33 HTLV)-1 HTLV)-1 NNP cord-345339-kyboibtq 80 34 and and CC cord-345339-kyboibtq 80 35 2 2 CD cord-345339-kyboibtq 80 36 , , , cord-345339-kyboibtq 80 37 and and CC cord-345339-kyboibtq 80 38 several several JJ cord-345339-kyboibtq 80 39 others other NNS cord-345339-kyboibtq 80 40 . . . cord-345339-kyboibtq 81 1 Direct direct JJ cord-345339-kyboibtq 81 2 proof proof NN cord-345339-kyboibtq 81 3 that that IN cord-345339-kyboibtq 81 4 a a DT cord-345339-kyboibtq 81 5 pathogen pathogen NN cord-345339-kyboibtq 81 6 is be VBZ cord-345339-kyboibtq 81 7 responsible responsible JJ cord-345339-kyboibtq 81 8 for for IN cord-345339-kyboibtq 81 9 the the DT cord-345339-kyboibtq 81 10 tissue tissue NN cord-345339-kyboibtq 81 11 damage damage NN cord-345339-kyboibtq 81 12 in in IN cord-345339-kyboibtq 81 13 MS MS NNP cord-345339-kyboibtq 81 14 requires require VBZ cord-345339-kyboibtq 81 15 isolating isolate VBG cord-345339-kyboibtq 81 16 the the DT cord-345339-kyboibtq 81 17 agent agent NN cord-345339-kyboibtq 81 18 from from IN cord-345339-kyboibtq 81 19 the the DT cord-345339-kyboibtq 81 20 diseased diseased JJ cord-345339-kyboibtq 81 21 nervous nervous JJ cord-345339-kyboibtq 81 22 system system NN cord-345339-kyboibtq 81 23 and and CC cord-345339-kyboibtq 81 24 demonstrating demonstrate VBG cord-345339-kyboibtq 81 25 that that IN cord-345339-kyboibtq 81 26 this this DT cord-345339-kyboibtq 81 27 finding finding NN cord-345339-kyboibtq 81 28 is be VBZ cord-345339-kyboibtq 81 29 disease disease NN cord-345339-kyboibtq 81 30 - - HYPH cord-345339-kyboibtq 81 31 specific specific JJ cord-345339-kyboibtq 81 32 . . . cord-345339-kyboibtq 82 1 So so RB cord-345339-kyboibtq 82 2 far far RB cord-345339-kyboibtq 82 3 , , , cord-345339-kyboibtq 82 4 this this DT cord-345339-kyboibtq 82 5 task task NN cord-345339-kyboibtq 82 6 has have VBZ cord-345339-kyboibtq 82 7 eluded elude VBN cord-345339-kyboibtq 82 8 researchers researcher NNS cord-345339-kyboibtq 82 9 : : : cord-345339-kyboibtq 82 10 no no DT cord-345339-kyboibtq 82 11 virus virus NN cord-345339-kyboibtq 82 12 or or CC cord-345339-kyboibtq 82 13 any any DT cord-345339-kyboibtq 82 14 other other JJ cord-345339-kyboibtq 82 15 infective infective JJ cord-345339-kyboibtq 82 16 agent agent NN cord-345339-kyboibtq 82 17 has have VBZ cord-345339-kyboibtq 82 18 met meet VBN cord-345339-kyboibtq 82 19 these these DT cord-345339-kyboibtq 82 20 criteria criterion NNS cord-345339-kyboibtq 82 21 . . . cord-345339-kyboibtq 83 1 Isolating isolate VBG cord-345339-kyboibtq 83 2 a a DT cord-345339-kyboibtq 83 3 pathogen pathogen NN cord-345339-kyboibtq 83 4 from from IN cord-345339-kyboibtq 83 5 MS MS NNP cord-345339-kyboibtq 83 6 patients patient NNS cord-345339-kyboibtq 83 7 ' ' POS cord-345339-kyboibtq 83 8 tissues tissue NNS cord-345339-kyboibtq 83 9 is be VBZ cord-345339-kyboibtq 83 10 based base VBN cord-345339-kyboibtq 83 11 on on IN cord-345339-kyboibtq 83 12 the the DT cord-345339-kyboibtq 83 13 available available JJ cord-345339-kyboibtq 83 14 technology technology NN cord-345339-kyboibtq 83 15 . . . cord-345339-kyboibtq 84 1 For for IN cord-345339-kyboibtq 84 2 more more JJR cord-345339-kyboibtq 84 3 than than IN cord-345339-kyboibtq 84 4 half half PDT cord-345339-kyboibtq 84 5 a a DT cord-345339-kyboibtq 84 6 century century NN cord-345339-kyboibtq 84 7 , , , cord-345339-kyboibtq 84 8 a a DT cord-345339-kyboibtq 84 9 wide wide JJ cord-345339-kyboibtq 84 10 spectrum spectrum NN cord-345339-kyboibtq 84 11 of of IN cord-345339-kyboibtq 84 12 laboratory laboratory NN cord-345339-kyboibtq 84 13 approaches approach NNS cord-345339-kyboibtq 84 14 has have VBZ cord-345339-kyboibtq 84 15 been be VBN cord-345339-kyboibtq 84 16 used use VBN cord-345339-kyboibtq 84 17 , , , cord-345339-kyboibtq 84 18 from from IN cord-345339-kyboibtq 84 19 cytopathic cytopathic JJ cord-345339-kyboibtq 84 20 effect effect NN cord-345339-kyboibtq 84 21 produced produce VBN cord-345339-kyboibtq 84 22 in in IN cord-345339-kyboibtq 84 23 culture culture NN cord-345339-kyboibtq 84 24 by by IN cord-345339-kyboibtq 84 25 fluids fluid NNS cord-345339-kyboibtq 84 26 isolated isolate VBN cord-345339-kyboibtq 84 27 from from IN cord-345339-kyboibtq 84 28 patients patient NNS cord-345339-kyboibtq 84 29 , , , cord-345339-kyboibtq 84 30 to to IN cord-345339-kyboibtq 84 31 viral viral JJ cord-345339-kyboibtq 84 32 culture culture NN cord-345339-kyboibtq 84 33 and and CC cord-345339-kyboibtq 84 34 cocultivation cocultivation NN cord-345339-kyboibtq 84 35 studies study NNS cord-345339-kyboibtq 84 36 , , , cord-345339-kyboibtq 84 37 to to IN cord-345339-kyboibtq 84 38 the the DT cord-345339-kyboibtq 84 39 present present JJ cord-345339-kyboibtq 84 40 polymerase polymerase NN cord-345339-kyboibtq 84 41 chain chain NN cord-345339-kyboibtq 84 42 reaction reaction NN cord-345339-kyboibtq 84 43 ( ( -LRB- cord-345339-kyboibtq 84 44 PCR pcr NN cord-345339-kyboibtq 84 45 ) ) -RRB- cord-345339-kyboibtq 84 46 amplification amplification NN cord-345339-kyboibtq 84 47 and and CC cord-345339-kyboibtq 84 48 representational representational JJ cord-345339-kyboibtq 84 49 difference difference NN cord-345339-kyboibtq 84 50 analysis analysis NN cord-345339-kyboibtq 84 51 . . . cord-345339-kyboibtq 85 1 A a DT cord-345339-kyboibtq 85 2 long long JJ cord-345339-kyboibtq 85 3 list list NN cord-345339-kyboibtq 85 4 of of IN cord-345339-kyboibtq 85 5 suspected suspect VBN cord-345339-kyboibtq 85 6 viruses virus NNS cord-345339-kyboibtq 85 7 includes include VBZ cord-345339-kyboibtq 85 8 rabies rabies NN cord-345339-kyboibtq 85 9 , , , cord-345339-kyboibtq 85 10 HSV HSV NNP cord-345339-kyboibtq 85 11 , , , cord-345339-kyboibtq 85 12 scrapie scrapie NN cord-345339-kyboibtq 85 13 agent agent NN cord-345339-kyboibtq 85 14 , , , cord-345339-kyboibtq 85 15 parainfluenza parainfluenza NNP cord-345339-kyboibtq 85 16 , , , cord-345339-kyboibtq 85 17 measles measle NNS cord-345339-kyboibtq 85 18 , , , cord-345339-kyboibtq 85 19 simian simian JJ cord-345339-kyboibtq 85 20 virus virus NN cord-345339-kyboibtq 85 21 V v NN cord-345339-kyboibtq 85 22 , , , cord-345339-kyboibtq 85 23 coronavirus coronavirus NN cord-345339-kyboibtq 85 24 , , , cord-345339-kyboibtq 85 25 HTLV-1 HTLV-1 NNP cord-345339-kyboibtq 85 26 , , , cord-345339-kyboibtq 85 27 and and CC cord-345339-kyboibtq 85 28 others other NNS cord-345339-kyboibtq 85 29 . . . cord-345339-kyboibtq 86 1 None none NN cord-345339-kyboibtq 86 2 has have VBZ cord-345339-kyboibtq 86 3 withstood withstand VBN cord-345339-kyboibtq 86 4 tests test NNS cord-345339-kyboibtq 86 5 of of IN cord-345339-kyboibtq 86 6 reproducibility reproducibility NN cord-345339-kyboibtq 86 7 , , , cord-345339-kyboibtq 86 8 specific specific JJ cord-345339-kyboibtq 86 9 presence presence NN cord-345339-kyboibtq 86 10 in in IN cord-345339-kyboibtq 86 11 a a DT cord-345339-kyboibtq 86 12 significant significant JJ cord-345339-kyboibtq 86 13 number number NN cord-345339-kyboibtq 86 14 of of IN cord-345339-kyboibtq 86 15 MS MS NNP cord-345339-kyboibtq 86 16 patients patient NNS cord-345339-kyboibtq 86 17 as as IN cord-345339-kyboibtq 86 18 compared compare VBN cord-345339-kyboibtq 86 19 with with IN cord-345339-kyboibtq 86 20 control control NN cord-345339-kyboibtq 86 21 patients patient NNS cord-345339-kyboibtq 86 22 , , , cord-345339-kyboibtq 86 23 or or CC cord-345339-kyboibtq 86 24 a a DT cord-345339-kyboibtq 86 25 reasonable reasonable JJ cord-345339-kyboibtq 86 26 experimental experimental JJ cord-345339-kyboibtq 86 27 explanation explanation NN cord-345339-kyboibtq 86 28 . . . cord-345339-kyboibtq 87 1 Nevertheless nevertheless RB cord-345339-kyboibtq 87 2 , , , cord-345339-kyboibtq 87 3 based base VBN cord-345339-kyboibtq 87 4 on on IN cord-345339-kyboibtq 87 5 the the DT cord-345339-kyboibtq 87 6 assumption assumption NN cord-345339-kyboibtq 87 7 that that IN cord-345339-kyboibtq 87 8 we -PRON- PRP cord-345339-kyboibtq 87 9 are be VBP cord-345339-kyboibtq 87 10 dealing deal VBG cord-345339-kyboibtq 87 11 with with IN cord-345339-kyboibtq 87 12 a a DT cord-345339-kyboibtq 87 13 heterogeneous heterogeneous JJ cord-345339-kyboibtq 87 14 entity entity NN cord-345339-kyboibtq 87 15 , , , cord-345339-kyboibtq 87 16 most most RBS cord-345339-kyboibtq 87 17 likely likely RB cord-345339-kyboibtq 87 18 a a DT cord-345339-kyboibtq 87 19 syndrome syndrome NN cord-345339-kyboibtq 87 20 , , , cord-345339-kyboibtq 87 21 it -PRON- PRP cord-345339-kyboibtq 87 22 is be VBZ cord-345339-kyboibtq 87 23 possible possible JJ cord-345339-kyboibtq 87 24 that that IN cord-345339-kyboibtq 87 25 the the DT cord-345339-kyboibtq 87 26 disorder disorder NN cord-345339-kyboibtq 87 27 is be VBZ cord-345339-kyboibtq 87 28 due due JJ cord-345339-kyboibtq 87 29 to to IN cord-345339-kyboibtq 87 30 many many JJ cord-345339-kyboibtq 87 31 different different JJ cord-345339-kyboibtq 87 32 pathogens pathogen NNS cord-345339-kyboibtq 87 33 , , , cord-345339-kyboibtq 87 34 where where WRB cord-345339-kyboibtq 87 35 in in IN cord-345339-kyboibtq 87 36 certain certain JJ cord-345339-kyboibtq 87 37 individual individual JJ cord-345339-kyboibtq 87 38 cases case NNS cord-345339-kyboibtq 87 39 , , , cord-345339-kyboibtq 87 40 an an DT cord-345339-kyboibtq 87 41 isolated isolated JJ cord-345339-kyboibtq 87 42 pathogen pathogen NN cord-345339-kyboibtq 87 43 is be VBZ cord-345339-kyboibtq 87 44 indeed indeed RB cord-345339-kyboibtq 87 45 responsible responsible JJ cord-345339-kyboibtq 87 46 for for IN cord-345339-kyboibtq 87 47 the the DT cord-345339-kyboibtq 87 48 disease disease NN cord-345339-kyboibtq 87 49 . . . cord-345339-kyboibtq 88 1 Therefore therefore RB cord-345339-kyboibtq 88 2 , , , cord-345339-kyboibtq 88 3 several several JJ cord-345339-kyboibtq 88 4 or or CC cord-345339-kyboibtq 88 5 all all DT cord-345339-kyboibtq 88 6 such such JJ cord-345339-kyboibtq 88 7 pathogens pathogen NNS cord-345339-kyboibtq 88 8 might may MD cord-345339-kyboibtq 88 9 cause cause VB cord-345339-kyboibtq 88 10 the the DT cord-345339-kyboibtq 88 11 disease disease NN cord-345339-kyboibtq 88 12 , , , cord-345339-kyboibtq 88 13 but but CC cord-345339-kyboibtq 88 14 would would MD cord-345339-kyboibtq 88 15 not not RB cord-345339-kyboibtq 88 16 stand stand VB cord-345339-kyboibtq 88 17 out out RP cord-345339-kyboibtq 88 18 when when WRB cord-345339-kyboibtq 88 19 examined examine VBN cord-345339-kyboibtq 88 20 on on IN cord-345339-kyboibtq 88 21 a a DT cord-345339-kyboibtq 88 22 large large JJ cord-345339-kyboibtq 88 23 series series NN cord-345339-kyboibtq 88 24 of of IN cord-345339-kyboibtq 88 25 patients patient NNS cord-345339-kyboibtq 88 26 . . . cord-345339-kyboibtq 89 1 As as IN cord-345339-kyboibtq 89 2 of of IN cord-345339-kyboibtq 89 3 today today NN cord-345339-kyboibtq 89 4 , , , cord-345339-kyboibtq 89 5 four four CD cord-345339-kyboibtq 89 6 pathogens pathogen NNS cord-345339-kyboibtq 89 7 are be VBP cord-345339-kyboibtq 89 8 under under IN cord-345339-kyboibtq 89 9 scrutiny scrutiny NN cord-345339-kyboibtq 89 10 , , , cord-345339-kyboibtq 89 11 and and CC cord-345339-kyboibtq 89 12 are be VBP cord-345339-kyboibtq 89 13 , , , cord-345339-kyboibtq 89 14 therefore therefore RB cord-345339-kyboibtq 89 15 , , , cord-345339-kyboibtq 89 16 discussed discuss VBN cord-345339-kyboibtq 89 17 here here RB cord-345339-kyboibtq 89 18 in in IN cord-345339-kyboibtq 89 19 more more JJR cord-345339-kyboibtq 89 20 depth depth NN cord-345339-kyboibtq 89 21 . . . cord-345339-kyboibtq 90 1 Human human JJ cord-345339-kyboibtq 90 2 herpes herpe NNS cord-345339-kyboibtq 90 3 virus virus NN cord-345339-kyboibtq 90 4 6 6 CD cord-345339-kyboibtq 90 5 ( ( -LRB- cord-345339-kyboibtq 90 6 HHV-6 HHV-6 NNP cord-345339-kyboibtq 90 7 ) ) -RRB- cord-345339-kyboibtq 90 8 is be VBZ cord-345339-kyboibtq 90 9 a a DT cord-345339-kyboibtq 90 10 lately lately RB cord-345339-kyboibtq 90 11 discovered discover VBN cord-345339-kyboibtq 90 12 DNA dna NN cord-345339-kyboibtq 90 13 virus virus NN cord-345339-kyboibtq 90 14 that that WDT cord-345339-kyboibtq 90 15 is be VBZ cord-345339-kyboibtq 90 16 responsible responsible JJ cord-345339-kyboibtq 90 17 for for IN cord-345339-kyboibtq 90 18 exanthema exanthema NNP cord-345339-kyboibtq 90 19 subitum subitum NNP cord-345339-kyboibtq 90 20 ( ( -LRB- cord-345339-kyboibtq 90 21 roseola roseola NNP cord-345339-kyboibtq 90 22 infantum infantum NNP cord-345339-kyboibtq 90 23 ) ) -RRB- cord-345339-kyboibtq 90 24 in in IN cord-345339-kyboibtq 90 25 children child NNS cord-345339-kyboibtq 90 26 ; ; : cord-345339-kyboibtq 90 27 up up IN cord-345339-kyboibtq 90 28 to to TO cord-345339-kyboibtq 90 29 95 95 CD cord-345339-kyboibtq 90 30 % % NN cord-345339-kyboibtq 90 31 of of IN cord-345339-kyboibtq 90 32 the the DT cord-345339-kyboibtq 90 33 general general JJ cord-345339-kyboibtq 90 34 population population NN cord-345339-kyboibtq 90 35 has have VBZ cord-345339-kyboibtq 90 36 been be VBN cord-345339-kyboibtq 90 37 exposed expose VBN cord-345339-kyboibtq 90 38 to to IN cord-345339-kyboibtq 90 39 it -PRON- PRP cord-345339-kyboibtq 90 40 [ [ -LRB- cord-345339-kyboibtq 90 41 23 23 CD cord-345339-kyboibtq 90 42 ] ] -RRB- cord-345339-kyboibtq 90 43 . . . cord-345339-kyboibtq 91 1 It -PRON- PRP cord-345339-kyboibtq 91 2 is be VBZ cord-345339-kyboibtq 91 3 a a DT cord-345339-kyboibtq 91 4 lymphotropic lymphotropic JJ cord-345339-kyboibtq 91 5 and and CC cord-345339-kyboibtq 91 6 a a DT cord-345339-kyboibtq 91 7 neurotropic neurotropic NNP cord-345339-kyboibtq 91 8 virus virus NN cord-345339-kyboibtq 91 9 that that WDT cord-345339-kyboibtq 91 10 has have VBZ cord-345339-kyboibtq 91 11 been be VBN cord-345339-kyboibtq 91 12 shown show VBN cord-345339-kyboibtq 91 13 to to TO cord-345339-kyboibtq 91 14 infect infect VB cord-345339-kyboibtq 91 15 glial glial JJ cord-345339-kyboibtq 91 16 cells cell NNS cord-345339-kyboibtq 91 17 in in IN cord-345339-kyboibtq 91 18 culture culture NN cord-345339-kyboibtq 91 19 [ [ -LRB- cord-345339-kyboibtq 91 20 24 24 CD cord-345339-kyboibtq 91 21 ] ] -RRB- cord-345339-kyboibtq 91 22 . . . cord-345339-kyboibtq 92 1 A a DT cord-345339-kyboibtq 92 2 look look NN cord-345339-kyboibtq 92 3 at at IN cord-345339-kyboibtq 92 4 control control NN cord-345339-kyboibtq 92 5 tissues tissue NNS cord-345339-kyboibtq 92 6 , , , cord-345339-kyboibtq 92 7 PCR PCR NNP cord-345339-kyboibtq 92 8 amplification amplification NN cord-345339-kyboibtq 92 9 of of IN cord-345339-kyboibtq 92 10 HHV-6 HHV-6 NNP cord-345339-kyboibtq 92 11 nucleic nucleic JJ cord-345339-kyboibtq 92 12 acids acid NNS cord-345339-kyboibtq 92 13 , , , cord-345339-kyboibtq 92 14 and and CC cord-345339-kyboibtq 92 15 representational representational JJ cord-345339-kyboibtq 92 16 difference difference NN cord-345339-kyboibtq 92 17 analysis analysis NN cord-345339-kyboibtq 92 18 ( ( -LRB- cord-345339-kyboibtq 92 19 the the DT cord-345339-kyboibtq 92 20 technology technology NN cord-345339-kyboibtq 92 21 that that WDT cord-345339-kyboibtq 92 22 enabled enable VBD cord-345339-kyboibtq 92 23 to to TO cord-345339-kyboibtq 92 24 link link VB cord-345339-kyboibtq 92 25 HHV-8 HHV-8 NNP cord-345339-kyboibtq 92 26 with with IN cord-345339-kyboibtq 92 27 Kaposi Kaposi NNP cord-345339-kyboibtq 92 28 's 's POS cord-345339-kyboibtq 92 29 sarcoma sarcoma NN cord-345339-kyboibtq 92 30 ) ) -RRB- cord-345339-kyboibtq 92 31 demonstrates demonstrate VBZ cord-345339-kyboibtq 92 32 that that IN cord-345339-kyboibtq 92 33 it -PRON- PRP cord-345339-kyboibtq 92 34 resides reside VBZ cord-345339-kyboibtq 92 35 in in IN cord-345339-kyboibtq 92 36 the the DT cord-345339-kyboibtq 92 37 nervous nervous JJ cord-345339-kyboibtq 92 38 system system NN cord-345339-kyboibtq 92 39 of of IN cord-345339-kyboibtq 92 40 the the DT cord-345339-kyboibtq 92 41 majority majority NN cord-345339-kyboibtq 92 42 of of IN cord-345339-kyboibtq 92 43 the the DT cord-345339-kyboibtq 92 44 population population NN cord-345339-kyboibtq 92 45 [ [ -LRB- cord-345339-kyboibtq 92 46 25 25 CD cord-345339-kyboibtq 92 47 ] ] -RRB- cord-345339-kyboibtq 92 48 . . . cord-345339-kyboibtq 93 1 HHV-6 HHV-6 NNP cord-345339-kyboibtq 93 2 has have VBZ cord-345339-kyboibtq 93 3 been be VBN cord-345339-kyboibtq 93 4 linked link VBN cord-345339-kyboibtq 93 5 with with IN cord-345339-kyboibtq 93 6 a a DT cord-345339-kyboibtq 93 7 variety variety NN cord-345339-kyboibtq 93 8 of of IN cord-345339-kyboibtq 93 9 acute acute JJ cord-345339-kyboibtq 93 10 and and CC cord-345339-kyboibtq 93 11 chronic chronic JJ cord-345339-kyboibtq 93 12 neurologic neurologic JJ cord-345339-kyboibtq 93 13 disorders disorder NNS cord-345339-kyboibtq 93 14 , , , cord-345339-kyboibtq 93 15 such such JJ cord-345339-kyboibtq 93 16 as as IN cord-345339-kyboibtq 93 17 encephalitis encephalitis JJ cord-345339-kyboibtq 93 18 [ [ -LRB- cord-345339-kyboibtq 93 19 26 26 CD cord-345339-kyboibtq 93 20 ] ] -RRB- cord-345339-kyboibtq 93 21 , , , cord-345339-kyboibtq 93 22 menin menin NNP cord-345339-kyboibtq 93 23 - - HYPH cord-345339-kyboibtq 93 24 goencephalitis goencephalitis NNP cord-345339-kyboibtq 93 25 [ [ -LRB- cord-345339-kyboibtq 93 26 27 27 CD cord-345339-kyboibtq 93 27 ] ] -RRB- cord-345339-kyboibtq 93 28 , , , cord-345339-kyboibtq 93 29 and and CC cord-345339-kyboibtq 93 30 myelopathy myelopathy NN cord-345339-kyboibtq 93 31 [ [ -LRB- cord-345339-kyboibtq 93 32 28 28 CD cord-345339-kyboibtq 93 33 ] ] -RRB- cord-345339-kyboibtq 93 34 under under IN cord-345339-kyboibtq 93 35 normal normal JJ cord-345339-kyboibtq 93 36 or or CC cord-345339-kyboibtq 93 37 immune immune JJ cord-345339-kyboibtq 93 38 - - HYPH cord-345339-kyboibtq 93 39 compromised compromise VBN cord-345339-kyboibtq 93 40 states state NNS cord-345339-kyboibtq 93 41 . . . cord-345339-kyboibtq 94 1 A a DT cord-345339-kyboibtq 94 2 possible possible JJ cord-345339-kyboibtq 94 3 association association NN cord-345339-kyboibtq 94 4 between between IN cord-345339-kyboibtq 94 5 HHV-6 HHV-6 NNP cord-345339-kyboibtq 94 6 and and CC cord-345339-kyboibtq 94 7 MS MS NNP cord-345339-kyboibtq 94 8 is be VBZ cord-345339-kyboibtq 94 9 suggested suggest VBN cord-345339-kyboibtq 94 10 by by IN cord-345339-kyboibtq 94 11 a a DT cord-345339-kyboibtq 94 12 number number NN cord-345339-kyboibtq 94 13 of of IN cord-345339-kyboibtq 94 14 studies study NNS cord-345339-kyboibtq 94 15 . . . cord-345339-kyboibtq 95 1 These these DT cord-345339-kyboibtq 95 2 include include VBP cord-345339-kyboibtq 95 3 studies study NNS cord-345339-kyboibtq 95 4 that that WDT cord-345339-kyboibtq 95 5 find find VBP cord-345339-kyboibtq 95 6 higher high JJR cord-345339-kyboibtq 95 7 levels level NNS cord-345339-kyboibtq 95 8 of of IN cord-345339-kyboibtq 95 9 anti anti JJ cord-345339-kyboibtq 95 10 - - JJ cord-345339-kyboibtq 95 11 HHV-6 HHV-6 NNP cord-345339-kyboibtq 95 12 antibodies antibody NNS cord-345339-kyboibtq 95 13 in in IN cord-345339-kyboibtq 95 14 the the DT cord-345339-kyboibtq 95 15 sera sera NNP cord-345339-kyboibtq 95 16 of of IN cord-345339-kyboibtq 95 17 patients patient NNS cord-345339-kyboibtq 95 18 with with IN cord-345339-kyboibtq 95 19 MS MS NNP cord-345339-kyboibtq 95 20 as as IN cord-345339-kyboibtq 95 21 compared compare VBN cord-345339-kyboibtq 95 22 with with IN cord-345339-kyboibtq 95 23 control control NN cord-345339-kyboibtq 95 24 patients patient NNS cord-345339-kyboibtq 95 25 [ [ -LRB- cord-345339-kyboibtq 95 26 29,30• 29,30• CD cord-345339-kyboibtq 95 27 ] ] -RRB- cord-345339-kyboibtq 95 28 , , , cord-345339-kyboibtq 95 29 studies study NNS cord-345339-kyboibtq 95 30 that that WDT cord-345339-kyboibtq 95 31 identify identify VBP cord-345339-kyboibtq 95 32 HHV-6 HHV-6 NNP cord-345339-kyboibtq 95 33 DNA DNA NNP cord-345339-kyboibtq 95 34 in in IN cord-345339-kyboibtq 95 35 a a DT cord-345339-kyboibtq 95 36 larger large JJR cord-345339-kyboibtq 95 37 percentage percentage NN cord-345339-kyboibtq 95 38 of of IN cord-345339-kyboibtq 95 39 MS MS NNP cord-345339-kyboibtq 95 40 patients patient NNS cord-345339-kyboibtq 95 41 compared compare VBN cord-345339-kyboibtq 95 42 with with IN cord-345339-kyboibtq 95 43 control control NN cord-345339-kyboibtq 95 44 patients patient NNS cord-345339-kyboibtq 95 45 [ [ -LRB- cord-345339-kyboibtq 95 46 30• 30• CD cord-345339-kyboibtq 95 47 ] ] -RRB- cord-345339-kyboibtq 95 48 ( ( -LRB- cord-345339-kyboibtq 95 49 findings finding NNS cord-345339-kyboibtq 95 50 which which WDT cord-345339-kyboibtq 95 51 are be VBP cord-345339-kyboibtq 95 52 not not RB cord-345339-kyboibtq 95 53 confirmed confirm VBN cord-345339-kyboibtq 95 54 by by IN cord-345339-kyboibtq 95 55 other other JJ cord-345339-kyboibtq 95 56 groups group NNS cord-345339-kyboibtq 95 57 [ [ -LRB- cord-345339-kyboibtq 95 58 31 31 CD cord-345339-kyboibtq 95 59 ] ] -RRB- cord-345339-kyboibtq 95 60 ) ) -RRB- cord-345339-kyboibtq 95 61 , , , cord-345339-kyboibtq 95 62 and and CC cord-345339-kyboibtq 95 63 evidence evidence NN cord-345339-kyboibtq 95 64 for for IN cord-345339-kyboibtq 95 65 HHV-6 HHV-6 NNP cord-345339-kyboibtq 95 66 gene gene NN cord-345339-kyboibtq 95 67 expression expression NN cord-345339-kyboibtq 95 68 in in IN cord-345339-kyboibtq 95 69 the the DT cord-345339-kyboibtq 95 70 brain brain NN cord-345339-kyboibtq 95 71 , , , cord-345339-kyboibtq 95 72 in in IN cord-345339-kyboibtq 95 73 oligodendrocytes oligodendrocyte NNS cord-345339-kyboibtq 95 74 , , , cord-345339-kyboibtq 95 75 and and CC cord-345339-kyboibtq 95 76 in in IN cord-345339-kyboibtq 95 77 plaques plaque NNS cord-345339-kyboibtq 95 78 of of IN cord-345339-kyboibtq 95 79 MS MS NNP cord-345339-kyboibtq 95 80 patients patient NNS cord-345339-kyboibtq 95 81 [ [ -LRB- cord-345339-kyboibtq 95 82 25,32• 25,32• CD cord-345339-kyboibtq 95 83 ] ] -RRB- cord-345339-kyboibtq 95 84 . . . cord-345339-kyboibtq 96 1 The the DT cord-345339-kyboibtq 96 2 latter latter JJ cord-345339-kyboibtq 96 3 findings finding NNS cord-345339-kyboibtq 96 4 , , , cord-345339-kyboibtq 96 5 however however RB cord-345339-kyboibtq 96 6 , , , cord-345339-kyboibtq 96 7 were be VBD cord-345339-kyboibtq 96 8 not not RB cord-345339-kyboibtq 96 9 confirmed confirm VBN cord-345339-kyboibtq 96 10 by by IN cord-345339-kyboibtq 96 11 other other JJ cord-345339-kyboibtq 96 12 researchers researcher NNS cord-345339-kyboibtq 96 13 [ [ -LRB- cord-345339-kyboibtq 96 14 33 33 CD cord-345339-kyboibtq 96 15 ] ] -RRB- cord-345339-kyboibtq 96 16 . . . cord-345339-kyboibtq 97 1 Although although IN cord-345339-kyboibtq 97 2 not not RB cord-345339-kyboibtq 97 3 unique unique JJ cord-345339-kyboibtq 97 4 to to IN cord-345339-kyboibtq 97 5 HHV-6 HHV-6 NNP cord-345339-kyboibtq 97 6 , , , cord-345339-kyboibtq 97 7 it -PRON- PRP cord-345339-kyboibtq 97 8 is be VBZ cord-345339-kyboibtq 97 9 important important JJ cord-345339-kyboibtq 97 10 to to TO cord-345339-kyboibtq 97 11 note note VB cord-345339-kyboibtq 97 12 that that IN cord-345339-kyboibtq 97 13 the the DT cord-345339-kyboibtq 97 14 timing timing NN cord-345339-kyboibtq 97 15 of of IN cord-345339-kyboibtq 97 16 exposure exposure NN cord-345339-kyboibtq 97 17 to to IN cord-345339-kyboibtq 97 18 the the DT cord-345339-kyboibtq 97 19 virus virus NN cord-345339-kyboibtq 97 20 corresponds correspond VBZ cord-345339-kyboibtq 97 21 with with IN cord-345339-kyboibtq 97 22 the the DT cord-345339-kyboibtq 97 23 exposure exposure NN cord-345339-kyboibtq 97 24 time time NN cord-345339-kyboibtq 97 25 to to IN cord-345339-kyboibtq 97 26 a a DT cord-345339-kyboibtq 97 27 possible possible JJ cord-345339-kyboibtq 97 28 infectious infectious JJ cord-345339-kyboibtq 97 29 pathogen pathogen NN cord-345339-kyboibtq 97 30 in in IN cord-345339-kyboibtq 97 31 MS MS NNP cord-345339-kyboibtq 97 32 . . . cord-345339-kyboibtq 98 1 At at IN cord-345339-kyboibtq 98 2 present present NN cord-345339-kyboibtq 98 3 , , , cord-345339-kyboibtq 98 4 the the DT cord-345339-kyboibtq 98 5 most most RBS cord-345339-kyboibtq 98 6 intriguing intriguing JJ cord-345339-kyboibtq 98 7 finding finding NN cord-345339-kyboibtq 98 8 is be VBZ cord-345339-kyboibtq 98 9 the the DT cord-345339-kyboibtq 98 10 association association NN cord-345339-kyboibtq 98 11 of of IN cord-345339-kyboibtq 98 12 HHV-6 HHV-6 NNP cord-345339-kyboibtq 98 13 with with IN cord-345339-kyboibtq 98 14 MS MS NNP cord-345339-kyboibtq 98 15 lesions lesion NNS cord-345339-kyboibtq 98 16 . . . cord-345339-kyboibtq 99 1 If if IN cord-345339-kyboibtq 99 2 confirmed confirm VBN cord-345339-kyboibtq 99 3 , , , cord-345339-kyboibtq 99 4 it -PRON- PRP cord-345339-kyboibtq 99 5 should should MD cord-345339-kyboibtq 99 6 lead lead VB cord-345339-kyboibtq 99 7 to to IN cord-345339-kyboibtq 99 8 the the DT cord-345339-kyboibtq 99 9 question question NN cord-345339-kyboibtq 99 10 whether whether IN cord-345339-kyboibtq 99 11 this this DT cord-345339-kyboibtq 99 12 is be VBZ cord-345339-kyboibtq 99 13 an an DT cord-345339-kyboibtq 99 14 outcome outcome NN cord-345339-kyboibtq 99 15 of of IN cord-345339-kyboibtq 99 16 the the DT cord-345339-kyboibtq 99 17 disease disease NN cord-345339-kyboibtq 99 18 ( ( -LRB- cord-345339-kyboibtq 99 19 or or CC cord-345339-kyboibtq 99 20 its -PRON- PRP$ cord-345339-kyboibtq 99 21 treatment treatment NN cord-345339-kyboibtq 99 22 , , , cord-345339-kyboibtq 99 23 as as IN cord-345339-kyboibtq 99 24 the the DT cord-345339-kyboibtq 99 25 immunosuppressive immunosuppressive JJ cord-345339-kyboibtq 99 26 and and CC cord-345339-kyboibtq 99 27 immunomodulatory immunomodulatory JJ cord-345339-kyboibtq 99 28 therapies therapy NNS cord-345339-kyboibtq 99 29 may may MD cord-345339-kyboibtq 99 30 induce induce VB cord-345339-kyboibtq 99 31 viral viral JJ cord-345339-kyboibtq 99 32 reactivation reactivation NN cord-345339-kyboibtq 99 33 with with IN cord-345339-kyboibtq 99 34 expression expression NN cord-345339-kyboibtq 99 35 of of IN cord-345339-kyboibtq 99 36 viral viral JJ cord-345339-kyboibtq 99 37 gene gene NN cord-345339-kyboibtq 99 38 products product NNS cord-345339-kyboibtq 99 39 ) ) -RRB- cord-345339-kyboibtq 99 40 , , , cord-345339-kyboibtq 99 41 a a DT cord-345339-kyboibtq 99 42 noncontributory noncontributory JJ cord-345339-kyboibtq 99 43 factor factor NN cord-345339-kyboibtq 99 44 , , , cord-345339-kyboibtq 99 45 or or CC cord-345339-kyboibtq 99 46 indeed indeed RB cord-345339-kyboibtq 99 47 related related JJ cord-345339-kyboibtq 99 48 to to IN cord-345339-kyboibtq 99 49 the the DT cord-345339-kyboibtq 99 50 pathogenesis pathogenesis NN cord-345339-kyboibtq 99 51 of of IN cord-345339-kyboibtq 99 52 the the DT cord-345339-kyboibtq 99 53 disease disease NN cord-345339-kyboibtq 99 54 . . . cord-345339-kyboibtq 100 1 Epstein Epstein NNP cord-345339-kyboibtq 100 2 - - HYPH cord-345339-kyboibtq 100 3 Barr Barr NNP cord-345339-kyboibtq 100 4 virus virus NN cord-345339-kyboibtq 100 5 is be VBZ cord-345339-kyboibtq 100 6 a a DT cord-345339-kyboibtq 100 7 lymphotrophic lymphotrophic NNP cord-345339-kyboibtq 100 8 herpes herpes NNP cord-345339-kyboibtq 100 9 virus virus NN cord-345339-kyboibtq 100 10 responsible responsible JJ cord-345339-kyboibtq 100 11 for for IN cord-345339-kyboibtq 100 12 infectious infectious JJ cord-345339-kyboibtq 100 13 mononucleosis mononucleosis NN cord-345339-kyboibtq 100 14 that that WDT cord-345339-kyboibtq 100 15 has have VBZ cord-345339-kyboibtq 100 16 been be VBN cord-345339-kyboibtq 100 17 associated associate VBN cord-345339-kyboibtq 100 18 with with IN cord-345339-kyboibtq 100 19 a a DT cord-345339-kyboibtq 100 20 spectrum spectrum NN cord-345339-kyboibtq 100 21 of of IN cord-345339-kyboibtq 100 22 neurologic neurologic JJ cord-345339-kyboibtq 100 23 disorders disorder NNS cord-345339-kyboibtq 100 24 , , , cord-345339-kyboibtq 100 25 including include VBG cord-345339-kyboibtq 100 26 certain certain JJ cord-345339-kyboibtq 100 27 CNS CNS NNP cord-345339-kyboibtq 100 28 lymphomas lymphoma NNS cord-345339-kyboibtq 100 29 . . . cord-345339-kyboibtq 101 1 Like like IN cord-345339-kyboibtq 101 2 other other JJ cord-345339-kyboibtq 101 3 herpes herpes NN cord-345339-kyboibtq 101 4 viruses virus NNS cord-345339-kyboibtq 101 5 , , , cord-345339-kyboibtq 101 6 it -PRON- PRP cord-345339-kyboibtq 101 7 establishes establish VBZ cord-345339-kyboibtq 101 8 latent latent JJ cord-345339-kyboibtq 101 9 infection infection NN cord-345339-kyboibtq 101 10 and and CC cord-345339-kyboibtq 101 11 can can MD cord-345339-kyboibtq 101 12 reactivate reactivate VB cord-345339-kyboibtq 101 13 later later RB cord-345339-kyboibtq 101 14 [ [ -LRB- cord-345339-kyboibtq 101 15 34 34 CD cord-345339-kyboibtq 101 16 ] ] -RRB- cord-345339-kyboibtq 101 17 . . . cord-345339-kyboibtq 102 1 In in IN cord-345339-kyboibtq 102 2 several several JJ cord-345339-kyboibtq 102 3 studies study NNS cord-345339-kyboibtq 102 4 , , , cord-345339-kyboibtq 102 5 EBV EBV NNP cord-345339-kyboibtq 102 6 was be VBD cord-345339-kyboibtq 102 7 found find VBN cord-345339-kyboibtq 102 8 to to TO cord-345339-kyboibtq 102 9 be be VB cord-345339-kyboibtq 102 10 present present JJ cord-345339-kyboibtq 102 11 or or CC cord-345339-kyboibtq 102 12 have have VBP cord-345339-kyboibtq 102 13 left leave VBN cord-345339-kyboibtq 102 14 evidence evidence NN cord-345339-kyboibtq 102 15 of of IN cord-345339-kyboibtq 102 16 previous previous JJ cord-345339-kyboibtq 102 17 exposure exposure NN cord-345339-kyboibtq 102 18 in in IN cord-345339-kyboibtq 102 19 a a DT cord-345339-kyboibtq 102 20 higher high JJR cord-345339-kyboibtq 102 21 percentage percentage NN cord-345339-kyboibtq 102 22 of of IN cord-345339-kyboibtq 102 23 MS MS NNP cord-345339-kyboibtq 102 24 patients patient NNS cord-345339-kyboibtq 102 25 compared compare VBN cord-345339-kyboibtq 102 26 with with IN cord-345339-kyboibtq 102 27 control control NN cord-345339-kyboibtq 102 28 patients patient NNS cord-345339-kyboibtq 102 29 [ [ -LRB- cord-345339-kyboibtq 102 30 35 35 CD cord-345339-kyboibtq 102 31 ] ] -RRB- cord-345339-kyboibtq 102 32 . . . cord-345339-kyboibtq 103 1 Likewise likewise RB cord-345339-kyboibtq 103 2 , , , cord-345339-kyboibtq 103 3 epidemiologic epidemiologic JJ cord-345339-kyboibtq 103 4 studies study NNS cord-345339-kyboibtq 103 5 suggest suggest VBP cord-345339-kyboibtq 103 6 a a DT cord-345339-kyboibtq 103 7 relationship relationship NN cord-345339-kyboibtq 103 8 between between IN cord-345339-kyboibtq 103 9 a a DT cord-345339-kyboibtq 103 10 previous previous JJ cord-345339-kyboibtq 103 11 EBV EBV NNP cord-345339-kyboibtq 103 12 infection infection NN cord-345339-kyboibtq 103 13 and and CC cord-345339-kyboibtq 103 14 MS MS NNP cord-345339-kyboibtq 103 15 [ [ -LRB- cord-345339-kyboibtq 103 16 19 19 CD cord-345339-kyboibtq 103 17 ] ] -RRB- cord-345339-kyboibtq 103 18 . . . cord-345339-kyboibtq 104 1 It -PRON- PRP cord-345339-kyboibtq 104 2 is be VBZ cord-345339-kyboibtq 104 3 worth worth JJ cord-345339-kyboibtq 104 4 noting note VBG cord-345339-kyboibtq 104 5 that that IN cord-345339-kyboibtq 104 6 , , , cord-345339-kyboibtq 104 7 during during IN cord-345339-kyboibtq 104 8 acute acute JJ cord-345339-kyboibtq 104 9 EBV EBV NNP cord-345339-kyboibtq 104 10 infections infection NNS cord-345339-kyboibtq 104 11 , , , cord-345339-kyboibtq 104 12 antibodies antibody NNS cord-345339-kyboibtq 104 13 that that WDT cord-345339-kyboibtq 104 14 crossreact crossreact VBP cord-345339-kyboibtq 104 15 with with IN cord-345339-kyboibtq 104 16 neuroglial neuroglial JJ cord-345339-kyboibtq 104 17 antigens antigen NNS cord-345339-kyboibtq 104 18 are be VBP cord-345339-kyboibtq 104 19 produced produce VBN cord-345339-kyboibtq 104 20 [ [ -LRB- cord-345339-kyboibtq 104 21 36 36 CD cord-345339-kyboibtq 104 22 ] ] -RRB- cord-345339-kyboibtq 104 23 . . . cord-345339-kyboibtq 105 1 However however RB cord-345339-kyboibtq 105 2 , , , cord-345339-kyboibtq 105 3 identification identification NN cord-345339-kyboibtq 105 4 of of IN cord-345339-kyboibtq 105 5 the the DT cord-345339-kyboibtq 105 6 pathogen(s pathogen(s NNP cord-345339-kyboibtq 105 7 ) ) -RRB- cord-345339-kyboibtq 105 8 in in IN cord-345339-kyboibtq 105 9 MS MS NNP cord-345339-kyboibtq 105 10 can can MD cord-345339-kyboibtq 105 11 not not RB cord-345339-kyboibtq 105 12 rely rely VB cord-345339-kyboibtq 105 13 on on IN cord-345339-kyboibtq 105 14 fingerprints fingerprint NNS cord-345339-kyboibtq 105 15 alone alone JJ cord-345339-kyboibtq 105 16 . . . cord-345339-kyboibtq 106 1 It -PRON- PRP cord-345339-kyboibtq 106 2 is be VBZ cord-345339-kyboibtq 106 3 mandatory mandatory JJ cord-345339-kyboibtq 106 4 to to TO cord-345339-kyboibtq 106 5 detect detect VB cord-345339-kyboibtq 106 6 presence presence NN cord-345339-kyboibtq 106 7 of of IN cord-345339-kyboibtq 106 8 viral viral JJ cord-345339-kyboibtq 106 9 nucleic nucleic JJ cord-345339-kyboibtq 106 10 acids acid NNS cord-345339-kyboibtq 107 1 and/or and/or CC cord-345339-kyboibtq 108 1 antigens antigen NNS cord-345339-kyboibtq 108 2 in in IN cord-345339-kyboibtq 108 3 the the DT cord-345339-kyboibtq 108 4 diseased diseased JJ cord-345339-kyboibtq 108 5 tissue tissue NN cord-345339-kyboibtq 108 6 , , , cord-345339-kyboibtq 108 7 which which WDT cord-345339-kyboibtq 108 8 should should MD cord-345339-kyboibtq 108 9 not not RB cord-345339-kyboibtq 108 10 constitute constitute VB cord-345339-kyboibtq 108 11 a a DT cord-345339-kyboibtq 108 12 technical technical JJ cord-345339-kyboibtq 108 13 problem problem NN cord-345339-kyboibtq 108 14 because because IN cord-345339-kyboibtq 108 15 EBV EBV NNP cord-345339-kyboibtq 108 16 is be VBZ cord-345339-kyboibtq 108 17 already already RB cord-345339-kyboibtq 108 18 revealed reveal VBN cord-345339-kyboibtq 108 19 and and CC cord-345339-kyboibtq 108 20 examined examine VBN cord-345339-kyboibtq 108 21 in in IN cord-345339-kyboibtq 108 22 certain certain JJ cord-345339-kyboibtq 108 23 CNS CNS NNP cord-345339-kyboibtq 108 24 lymphomas lymphoma NNS cord-345339-kyboibtq 108 25 . . . cord-345339-kyboibtq 109 1 We -PRON- PRP cord-345339-kyboibtq 109 2 are be VBP cord-345339-kyboibtq 109 3 not not RB cord-345339-kyboibtq 109 4 aware aware JJ cord-345339-kyboibtq 109 5 of of IN cord-345339-kyboibtq 109 6 any any DT cord-345339-kyboibtq 109 7 report report NN cord-345339-kyboibtq 109 8 on on IN cord-345339-kyboibtq 109 9 the the DT cord-345339-kyboibtq 109 10 presence presence NN cord-345339-kyboibtq 109 11 or or CC cord-345339-kyboibtq 109 12 absence absence NN cord-345339-kyboibtq 109 13 of of IN cord-345339-kyboibtq 109 14 such such JJ cord-345339-kyboibtq 109 15 compounds compound NNS cord-345339-kyboibtq 109 16 in in IN cord-345339-kyboibtq 109 17 brain brain NN cord-345339-kyboibtq 109 18 tissues tissue NNS cord-345339-kyboibtq 109 19 of of IN cord-345339-kyboibtq 109 20 MS MS NNP cord-345339-kyboibtq 109 21 patients patient NNS cord-345339-kyboibtq 109 22 . . . cord-345339-kyboibtq 110 1 Retroviruses retrovirus NNS cord-345339-kyboibtq 110 2 are be VBP cord-345339-kyboibtq 110 3 RNA RNA NNP cord-345339-kyboibtq 110 4 viruses virus NNS cord-345339-kyboibtq 110 5 that that WDT cord-345339-kyboibtq 110 6 encode encode VBP cord-345339-kyboibtq 110 7 proviral proviral JJ cord-345339-kyboibtq 110 8 DNA DNA NNP cord-345339-kyboibtq 110 9 integrated integrate VBN cord-345339-kyboibtq 110 10 into into IN cord-345339-kyboibtq 110 11 the the DT cord-345339-kyboibtq 110 12 host host NN cord-345339-kyboibtq 110 13 cell cell NN cord-345339-kyboibtq 110 14 genome genome NN cord-345339-kyboibtq 110 15 and and CC cord-345339-kyboibtq 110 16 can can MD cord-345339-kyboibtq 110 17 be be VB cord-345339-kyboibtq 110 18 transmitted transmit VBN cord-345339-kyboibtq 110 19 via via IN cord-345339-kyboibtq 110 20 the the DT cord-345339-kyboibtq 110 21 germ germ NN cord-345339-kyboibtq 110 22 line line NN cord-345339-kyboibtq 110 23 [ [ -LRB- cord-345339-kyboibtq 110 24 37 37 CD cord-345339-kyboibtq 110 25 ] ] -RRB- cord-345339-kyboibtq 110 26 . . . cord-345339-kyboibtq 111 1 Endogenous endogenous JJ cord-345339-kyboibtq 111 2 retroviral retroviral NN cord-345339-kyboibtq 111 3 sequences sequence NNS cord-345339-kyboibtq 111 4 constitute constitute VBP cord-345339-kyboibtq 111 5 up up IN cord-345339-kyboibtq 111 6 to to TO cord-345339-kyboibtq 111 7 20 20 CD cord-345339-kyboibtq 111 8 % % NN cord-345339-kyboibtq 111 9 of of IN cord-345339-kyboibtq 111 10 the the DT cord-345339-kyboibtq 111 11 human human JJ cord-345339-kyboibtq 111 12 genome genome NN cord-345339-kyboibtq 111 13 . . . cord-345339-kyboibtq 112 1 The the DT cord-345339-kyboibtq 112 2 retrovirus retrovirus NN cord-345339-kyboibtq 112 3 visna visna NN cord-345339-kyboibtq 112 4 , , , cord-345339-kyboibtq 112 5 found find VBN cord-345339-kyboibtq 112 6 in in IN cord-345339-kyboibtq 112 7 sheep sheep NN cord-345339-kyboibtq 112 8 , , , cord-345339-kyboibtq 112 9 was be VBD cord-345339-kyboibtq 112 10 one one CD cord-345339-kyboibtq 112 11 of of IN cord-345339-kyboibtq 112 12 the the DT cord-345339-kyboibtq 112 13 first first JJ cord-345339-kyboibtq 112 14 animal animal NN cord-345339-kyboibtq 112 15 models model NNS cord-345339-kyboibtq 112 16 of of IN cord-345339-kyboibtq 112 17 a a DT cord-345339-kyboibtq 112 18 demyelinating demyelinating JJ cord-345339-kyboibtq 112 19 disease disease NN cord-345339-kyboibtq 112 20 , , , cord-345339-kyboibtq 112 21 and and CC cord-345339-kyboibtq 112 22 HTLV-1 HTLV-1 NNP cord-345339-kyboibtq 112 23 , , , cord-345339-kyboibtq 112 24 which which WDT cord-345339-kyboibtq 112 25 can can MD cord-345339-kyboibtq 112 26 cause cause VB cord-345339-kyboibtq 112 27 a a DT cord-345339-kyboibtq 112 28 human human JJ cord-345339-kyboibtq 112 29 demyelinating demyelinate VBG cord-345339-kyboibtq 112 30 chronic chronic JJ cord-345339-kyboibtq 112 31 myelopathy myelopathy NN cord-345339-kyboibtq 112 32 , , , cord-345339-kyboibtq 112 33 was be VBD cord-345339-kyboibtq 112 34 implicated implicate VBN cord-345339-kyboibtq 112 35 , , , cord-345339-kyboibtq 112 36 but but CC cord-345339-kyboibtq 112 37 not not RB cord-345339-kyboibtq 112 38 confirmed confirm VBN cord-345339-kyboibtq 112 39 , , , cord-345339-kyboibtq 112 40 as as IN cord-345339-kyboibtq 112 41 the the DT cord-345339-kyboibtq 112 42 cause cause NN cord-345339-kyboibtq 112 43 of of IN cord-345339-kyboibtq 112 44 MS MS NNP cord-345339-kyboibtq 112 45 . . . cord-345339-kyboibtq 113 1 In in IN cord-345339-kyboibtq 113 2 the the DT cord-345339-kyboibtq 113 3 past past JJ cord-345339-kyboibtq 113 4 decade decade NN cord-345339-kyboibtq 113 5 , , , cord-345339-kyboibtq 113 6 another another DT cord-345339-kyboibtq 113 7 , , , cord-345339-kyboibtq 113 8 yet yet RB cord-345339-kyboibtq 113 9 unidentified unidentified JJ cord-345339-kyboibtq 113 10 , , , cord-345339-kyboibtq 113 11 retrovirus retrovirus NN cord-345339-kyboibtq 113 12 has have VBZ cord-345339-kyboibtq 113 13 been be VBN cord-345339-kyboibtq 113 14 traced trace VBN cord-345339-kyboibtq 113 15 . . . cord-345339-kyboibtq 114 1 Activity activity NN cord-345339-kyboibtq 114 2 of of IN cord-345339-kyboibtq 114 3 the the DT cord-345339-kyboibtq 114 4 retroviral retroviral JJ cord-345339-kyboibtq 114 5 enzyme enzyme NN cord-345339-kyboibtq 114 6 reverse reverse NN cord-345339-kyboibtq 114 7 transcriptase transcriptase NN cord-345339-kyboibtq 114 8 was be VBD cord-345339-kyboibtq 114 9 identified identify VBN cord-345339-kyboibtq 114 10 in in IN cord-345339-kyboibtq 114 11 tissues tissue NNS cord-345339-kyboibtq 114 12 and and CC cord-345339-kyboibtq 114 13 cells cell NNS cord-345339-kyboibtq 114 14 from from IN cord-345339-kyboibtq 114 15 MS MS NNP cord-345339-kyboibtq 114 16 patients patient NNS cord-345339-kyboibtq 114 17 [ [ -LRB- cord-345339-kyboibtq 114 18 38• 38• CD cord-345339-kyboibtq 114 19 ] ] -RRB- cord-345339-kyboibtq 114 20 , , , cord-345339-kyboibtq 114 21 as as RB cord-345339-kyboibtq 114 22 well well RB cord-345339-kyboibtq 114 23 as as IN cord-345339-kyboibtq 114 24 retroviral retroviral JJ cord-345339-kyboibtq 114 25 sequences sequence NNS cord-345339-kyboibtq 114 26 in in IN cord-345339-kyboibtq 114 27 the the DT cord-345339-kyboibtq 114 28 CSF CSF NNP cord-345339-kyboibtq 114 29 [ [ -LRB- cord-345339-kyboibtq 114 30 38• 38• CD cord-345339-kyboibtq 114 31 ] ] -RRB- cord-345339-kyboibtq 114 32 and and CC cord-345339-kyboibtq 114 33 serum serum NN cord-345339-kyboibtq 114 34 [ [ -LRB- cord-345339-kyboibtq 114 35 39 39 CD cord-345339-kyboibtq 114 36 ] ] -RRB- cord-345339-kyboibtq 114 37 . . . cord-345339-kyboibtq 115 1 This this DT cord-345339-kyboibtq 115 2 has have VBZ cord-345339-kyboibtq 115 3 come come VBN cord-345339-kyboibtq 115 4 to to TO cord-345339-kyboibtq 115 5 be be VB cord-345339-kyboibtq 115 6 termed term VBN cord-345339-kyboibtq 115 7 MSassociated msassociate VBN cord-345339-kyboibtq 115 8 retrovirus retrovirus NN cord-345339-kyboibtq 115 9 ( ( -LRB- cord-345339-kyboibtq 115 10 MSRV MSRV NNP cord-345339-kyboibtq 115 11 ) ) -RRB- cord-345339-kyboibtq 115 12 . . . cord-345339-kyboibtq 116 1 Indeed indeed RB cord-345339-kyboibtq 116 2 , , , cord-345339-kyboibtq 116 3 endogenous endogenous JJ cord-345339-kyboibtq 116 4 retrovirus retrovirus NN cord-345339-kyboibtq 116 5 can can MD cord-345339-kyboibtq 116 6 theoretically theoretically RB cord-345339-kyboibtq 116 7 induce induce VB cord-345339-kyboibtq 116 8 an an DT cord-345339-kyboibtq 116 9 immune immune NN cord-345339-kyboibtq 116 10 - - HYPH cord-345339-kyboibtq 116 11 mediated mediate VBN cord-345339-kyboibtq 116 12 condition condition NN cord-345339-kyboibtq 116 13 [ [ -LRB- cord-345339-kyboibtq 116 14 40 40 CD cord-345339-kyboibtq 116 15 ] ] -RRB- cord-345339-kyboibtq 116 16 or or CC cord-345339-kyboibtq 116 17 an an DT cord-345339-kyboibtq 116 18 infectious infectious JJ cord-345339-kyboibtq 116 19 process process NN cord-345339-kyboibtq 116 20 per per FW cord-345339-kyboibtq 116 21 se se FW cord-345339-kyboibtq 116 22 . . . cord-345339-kyboibtq 117 1 Unfortunately unfortunately RB cord-345339-kyboibtq 117 2 , , , cord-345339-kyboibtq 117 3 other other JJ cord-345339-kyboibtq 117 4 groups group NNS cord-345339-kyboibtq 117 5 were be VBD cord-345339-kyboibtq 117 6 unable unable JJ cord-345339-kyboibtq 117 7 to to TO cord-345339-kyboibtq 117 8 confirm confirm VB cord-345339-kyboibtq 117 9 these these DT cord-345339-kyboibtq 117 10 findings finding NNS cord-345339-kyboibtq 117 11 , , , cord-345339-kyboibtq 117 12 and and CC cord-345339-kyboibtq 117 13 there there EX cord-345339-kyboibtq 117 14 is be VBZ cord-345339-kyboibtq 117 15 a a DT cord-345339-kyboibtq 117 16 similarity similarity NN cord-345339-kyboibtq 117 17 between between IN cord-345339-kyboibtq 117 18 the the DT cord-345339-kyboibtq 117 19 identified identify VBN cord-345339-kyboibtq 117 20 sequences sequence NNS cord-345339-kyboibtq 117 21 and and CC cord-345339-kyboibtq 117 22 those those DT cord-345339-kyboibtq 117 23 of of IN cord-345339-kyboibtq 117 24 endogenous endogenous JJ cord-345339-kyboibtq 117 25 retroviruses retrovirus NNS cord-345339-kyboibtq 117 26 present present JJ cord-345339-kyboibtq 117 27 in in IN cord-345339-kyboibtq 117 28 the the DT cord-345339-kyboibtq 117 29 majority majority NN cord-345339-kyboibtq 117 30 of of IN cord-345339-kyboibtq 117 31 the the DT cord-345339-kyboibtq 117 32 population population NN cord-345339-kyboibtq 117 33 [ [ -LRB- cord-345339-kyboibtq 117 34 38• 38• CD cord-345339-kyboibtq 117 35 ] ] -RRB- cord-345339-kyboibtq 117 36 . . . cord-345339-kyboibtq 118 1 A a DT cord-345339-kyboibtq 118 2 collaboration collaboration NN cord-345339-kyboibtq 118 3 between between IN cord-345339-kyboibtq 118 4 a a DT cord-345339-kyboibtq 118 5 retrovirus retrovirus NN cord-345339-kyboibtq 118 6 and and CC cord-345339-kyboibtq 118 7 EBV EBV NNP cord-345339-kyboibtq 118 8 in in IN cord-345339-kyboibtq 118 9 inducing induce VBG cord-345339-kyboibtq 118 10 MS MS NNP cord-345339-kyboibtq 118 11 and and CC cord-345339-kyboibtq 118 12 triggering trigger VBG cord-345339-kyboibtq 118 13 the the DT cord-345339-kyboibtq 118 14 relapses relapse NNS cord-345339-kyboibtq 118 15 has have VBZ cord-345339-kyboibtq 118 16 also also RB cord-345339-kyboibtq 118 17 been be VBN cord-345339-kyboibtq 118 18 suggested suggest VBN cord-345339-kyboibtq 118 19 [ [ -LRB- cord-345339-kyboibtq 118 20 41• 41• CD cord-345339-kyboibtq 118 21 ] ] -RRB- cord-345339-kyboibtq 118 22 . . . cord-345339-kyboibtq 119 1 The the DT cord-345339-kyboibtq 119 2 hypothesis hypothesis NN cord-345339-kyboibtq 119 3 is be VBZ cord-345339-kyboibtq 119 4 based base VBN cord-345339-kyboibtq 119 5 on on IN cord-345339-kyboibtq 119 6 the the DT cord-345339-kyboibtq 119 7 observation observation NN cord-345339-kyboibtq 119 8 that that IN cord-345339-kyboibtq 119 9 herpes herpes NN cord-345339-kyboibtq 119 10 viruses virus NNS cord-345339-kyboibtq 119 11 can can MD cord-345339-kyboibtq 119 12 transactivate transactivate VB cord-345339-kyboibtq 119 13 retroviruses retrovirus NNS cord-345339-kyboibtq 119 14 [ [ -LRB- cord-345339-kyboibtq 119 15 42 42 CD cord-345339-kyboibtq 119 16 ] ] -RRB- cord-345339-kyboibtq 119 17 , , , cord-345339-kyboibtq 119 18 and and CC cord-345339-kyboibtq 119 19 on on IN cord-345339-kyboibtq 119 20 the the DT cord-345339-kyboibtq 119 21 ability ability NN cord-345339-kyboibtq 119 22 of of IN cord-345339-kyboibtq 119 23 herpes herpes NN cord-345339-kyboibtq 119 24 viruses virus NNS cord-345339-kyboibtq 119 25 to to TO cord-345339-kyboibtq 119 26 reactivate reactivate VB cord-345339-kyboibtq 119 27 periodically periodically RB cord-345339-kyboibtq 119 28 and and CC cord-345339-kyboibtq 119 29 induce induce VB cord-345339-kyboibtq 119 30 recurrent recurrent JJ cord-345339-kyboibtq 119 31 disease disease NN cord-345339-kyboibtq 119 32 [ [ -LRB- cord-345339-kyboibtq 119 33 34 34 CD cord-345339-kyboibtq 119 34 ] ] -RRB- cord-345339-kyboibtq 119 35 . . . cord-345339-kyboibtq 120 1 Chlamydia Chlamydia NNP cord-345339-kyboibtq 120 2 pneumoniae pneumoniae NN cord-345339-kyboibtq 120 3 is be VBZ cord-345339-kyboibtq 120 4 an an DT cord-345339-kyboibtq 120 5 obligate obligate JJ cord-345339-kyboibtq 120 6 , , , cord-345339-kyboibtq 120 7 intracellular intracellular JJ cord-345339-kyboibtq 120 8 , , , cord-345339-kyboibtq 120 9 gramnegative gramnegative JJ cord-345339-kyboibtq 120 10 bacterium bacterium NN cord-345339-kyboibtq 120 11 known know VBN cord-345339-kyboibtq 120 12 to to TO cord-345339-kyboibtq 120 13 cause cause VB cord-345339-kyboibtq 120 14 respiratory respiratory JJ cord-345339-kyboibtq 120 15 infections infection NNS cord-345339-kyboibtq 120 16 in in IN cord-345339-kyboibtq 120 17 humans human NNS cord-345339-kyboibtq 120 18 . . . cord-345339-kyboibtq 121 1 The the DT cord-345339-kyboibtq 121 2 organism organism NN cord-345339-kyboibtq 121 3 has have VBZ cord-345339-kyboibtq 121 4 also also RB cord-345339-kyboibtq 121 5 been be VBN cord-345339-kyboibtq 121 6 implicated implicate VBN cord-345339-kyboibtq 121 7 in in IN cord-345339-kyboibtq 121 8 a a DT cord-345339-kyboibtq 121 9 wide wide JJ cord-345339-kyboibtq 121 10 variety variety NN cord-345339-kyboibtq 121 11 of of IN cord-345339-kyboibtq 121 12 disorders disorder NNS cord-345339-kyboibtq 121 13 ranging range VBG cord-345339-kyboibtq 121 14 from from IN cord-345339-kyboibtq 121 15 asthma asthma NN cord-345339-kyboibtq 121 16 , , , cord-345339-kyboibtq 121 17 atherosclerotic atherosclerotic JJ cord-345339-kyboibtq 121 18 vascular vascular JJ cord-345339-kyboibtq 121 19 disease disease NN cord-345339-kyboibtq 121 20 , , , cord-345339-kyboibtq 121 21 and and CC cord-345339-kyboibtq 121 22 arthritis arthritis NN cord-345339-kyboibtq 121 23 to to IN cord-345339-kyboibtq 121 24 Guillain Guillain NNP cord-345339-kyboibtq 121 25 - - HYPH cord-345339-kyboibtq 121 26 Barre Barre NNP cord-345339-kyboibtq 121 27 syndrome syndrome NN cord-345339-kyboibtq 121 28 and and CC cord-345339-kyboibtq 121 29 encephalitis encephalitis NN cord-345339-kyboibtq 121 30 . . . cord-345339-kyboibtq 122 1 The the DT cord-345339-kyboibtq 122 2 possible possible JJ cord-345339-kyboibtq 122 3 relation relation NN cord-345339-kyboibtq 122 4 of of IN cord-345339-kyboibtq 122 5 Chlamydia Chlamydia NNP cord-345339-kyboibtq 122 6 to to IN cord-345339-kyboibtq 122 7 MS MS NNP cord-345339-kyboibtq 122 8 was be VBD cord-345339-kyboibtq 122 9 recently recently RB cord-345339-kyboibtq 122 10 resurrected resurrect VBN cord-345339-kyboibtq 122 11 by by IN cord-345339-kyboibtq 122 12 a a DT cord-345339-kyboibtq 122 13 case case NN cord-345339-kyboibtq 122 14 report report NN cord-345339-kyboibtq 122 15 of of IN cord-345339-kyboibtq 122 16 a a DT cord-345339-kyboibtq 122 17 24-year 24-year JJ cord-345339-kyboibtq 122 18 - - HYPH cord-345339-kyboibtq 122 19 old old JJ cord-345339-kyboibtq 122 20 man man NN cord-345339-kyboibtq 122 21 who who WP cord-345339-kyboibtq 122 22 presented present VBD cord-345339-kyboibtq 122 23 with with IN cord-345339-kyboibtq 122 24 a a DT cord-345339-kyboibtq 122 25 fulminant fulminant JJ cord-345339-kyboibtq 122 26 MSlike MSlike NNP cord-345339-kyboibtq 122 27 disease disease NN cord-345339-kyboibtq 122 28 [ [ -LRB- cord-345339-kyboibtq 122 29 43 43 CD cord-345339-kyboibtq 122 30 ] ] -RRB- cord-345339-kyboibtq 122 31 . . . cord-345339-kyboibtq 123 1 His -PRON- PRP$ cord-345339-kyboibtq 123 2 condition condition NN cord-345339-kyboibtq 123 3 deteriorated deteriorate VBD cord-345339-kyboibtq 123 4 despite despite IN cord-345339-kyboibtq 123 5 corticosteroid corticosteroid NN cord-345339-kyboibtq 123 6 and and CC cord-345339-kyboibtq 123 7 β β NN cord-345339-kyboibtq 123 8 - - HYPH cord-345339-kyboibtq 123 9 interferon interferon NN cord-345339-kyboibtq 123 10 therapy therapy NN cord-345339-kyboibtq 123 11 . . . cord-345339-kyboibtq 124 1 Although although IN cord-345339-kyboibtq 124 2 treated treat VBN cord-345339-kyboibtq 124 3 with with IN cord-345339-kyboibtq 124 4 cyclophosphamide cyclophosphamide NN cord-345339-kyboibtq 124 5 , , , cord-345339-kyboibtq 124 6 CSF CSF NNP cord-345339-kyboibtq 124 7 cultures culture NNS cord-345339-kyboibtq 124 8 and and CC cord-345339-kyboibtq 124 9 PCR PCR NNP cord-345339-kyboibtq 124 10 analysis analysis NN cord-345339-kyboibtq 124 11 turned turn VBD cord-345339-kyboibtq 124 12 out out RP cord-345339-kyboibtq 124 13 to to TO cord-345339-kyboibtq 124 14 be be VB cord-345339-kyboibtq 124 15 positive positive JJ cord-345339-kyboibtq 124 16 for for IN cord-345339-kyboibtq 124 17 Chlamydia Chlamydia NNP cord-345339-kyboibtq 124 18 pneumoniae pneumoniae NN cord-345339-kyboibtq 124 19 , , , cord-345339-kyboibtq 124 20 and and CC cord-345339-kyboibtq 124 21 prolonged prolong VBD cord-345339-kyboibtq 124 22 antibiotic antibiotic JJ cord-345339-kyboibtq 124 23 therapy therapy NN cord-345339-kyboibtq 124 24 was be VBD cord-345339-kyboibtq 124 25 associated associate VBN cord-345339-kyboibtq 124 26 with with IN cord-345339-kyboibtq 124 27 neurologic neurologic JJ cord-345339-kyboibtq 124 28 recovery recovery NN cord-345339-kyboibtq 124 29 . . . cord-345339-kyboibtq 125 1 This this DT cord-345339-kyboibtq 125 2 report report NN cord-345339-kyboibtq 125 3 was be VBD cord-345339-kyboibtq 125 4 followed follow VBN cord-345339-kyboibtq 125 5 by by IN cord-345339-kyboibtq 125 6 analysis analysis NN cord-345339-kyboibtq 125 7 of of IN cord-345339-kyboibtq 125 8 37 37 CD cord-345339-kyboibtq 125 9 additional additional JJ cord-345339-kyboibtq 125 10 patients patient NNS cord-345339-kyboibtq 125 11 from from IN cord-345339-kyboibtq 125 12 the the DT cord-345339-kyboibtq 125 13 same same JJ cord-345339-kyboibtq 125 14 center center NN cord-345339-kyboibtq 125 15 [ [ -LRB- cord-345339-kyboibtq 125 16 44•• 44•• CD cord-345339-kyboibtq 125 17 ] ] -RRB- cord-345339-kyboibtq 125 18 , , , cord-345339-kyboibtq 125 19 showing show VBG cord-345339-kyboibtq 125 20 64 64 CD cord-345339-kyboibtq 125 21 % % NN cord-345339-kyboibtq 125 22 of of IN cord-345339-kyboibtq 125 23 CSF csf NN cord-345339-kyboibtq 125 24 samples sample NNS cord-345339-kyboibtq 125 25 culture culture NN cord-345339-kyboibtq 125 26 - - HYPH cord-345339-kyboibtq 125 27 positive positive JJ cord-345339-kyboibtq 125 28 , , , cord-345339-kyboibtq 125 29 and and CC cord-345339-kyboibtq 125 30 97 97 CD cord-345339-kyboibtq 125 31 % % NN cord-345339-kyboibtq 125 32 PCR pcr NN cord-345339-kyboibtq 125 33 - - HYPH cord-345339-kyboibtq 125 34 positive positive JJ cord-345339-kyboibtq 125 35 for for IN cord-345339-kyboibtq 125 36 the the DT cord-345339-kyboibtq 125 37 organism organism NN cord-345339-kyboibtq 125 38 , , , cord-345339-kyboibtq 125 39 ( ( -LRB- cord-345339-kyboibtq 125 40 compared compare VBN cord-345339-kyboibtq 125 41 with with IN cord-345339-kyboibtq 125 42 11 11 CD cord-345339-kyboibtq 125 43 % % NN cord-345339-kyboibtq 125 44 and and CC cord-345339-kyboibtq 125 45 18 18 CD cord-345339-kyboibtq 125 46 % % NN cord-345339-kyboibtq 125 47 in in IN cord-345339-kyboibtq 125 48 control control NN cord-345339-kyboibtq 125 49 patients patient NNS cord-345339-kyboibtq 125 50 , , , cord-345339-kyboibtq 125 51 respectively respectively RB cord-345339-kyboibtq 125 52 ) ) -RRB- cord-345339-kyboibtq 125 53 , , , cord-345339-kyboibtq 125 54 and and CC cord-345339-kyboibtq 125 55 86 86 CD cord-345339-kyboibtq 125 56 % % NN cord-345339-kyboibtq 125 57 with with IN cord-345339-kyboibtq 125 58 CSF CSF NNP cord-345339-kyboibtq 125 59 anti anti NNP cord-345339-kyboibtq 125 60 - - JJ cord-345339-kyboibtq 125 61 Chlamydia chlamydia JJ cord-345339-kyboibtq 125 62 antibodies antibody NNS cord-345339-kyboibtq 125 63 . . . cord-345339-kyboibtq 126 1 These these DT cord-345339-kyboibtq 126 2 findings finding NNS cord-345339-kyboibtq 126 3 were be VBD cord-345339-kyboibtq 126 4 supported support VBN cord-345339-kyboibtq 126 5 by by IN cord-345339-kyboibtq 126 6 one one CD cord-345339-kyboibtq 126 7 group group NN cord-345339-kyboibtq 126 8 [ [ -LRB- cord-345339-kyboibtq 126 9 45 45 CD cord-345339-kyboibtq 126 10 ] ] -RRB- cord-345339-kyboibtq 126 11 , , , cord-345339-kyboibtq 126 12 but but CC cord-345339-kyboibtq 126 13 not not RB cord-345339-kyboibtq 126 14 by by IN cord-345339-kyboibtq 126 15 others other NNS cord-345339-kyboibtq 126 16 [ [ -LRB- cord-345339-kyboibtq 126 17 46 46 CD cord-345339-kyboibtq 126 18 ] ] -RRB- cord-345339-kyboibtq 126 19 . . . cord-345339-kyboibtq 127 1 Although although IN cord-345339-kyboibtq 127 2 the the DT cord-345339-kyboibtq 127 3 discrepancies discrepancy NNS cord-345339-kyboibtq 127 4 may may MD cord-345339-kyboibtq 127 5 be be VB cord-345339-kyboibtq 127 6 due due JJ cord-345339-kyboibtq 127 7 to to IN cord-345339-kyboibtq 127 8 lack lack NN cord-345339-kyboibtq 127 9 of of IN cord-345339-kyboibtq 127 10 uniform uniform JJ cord-345339-kyboibtq 127 11 standards standard NNS cord-345339-kyboibtq 127 12 and and CC cord-345339-kyboibtq 127 13 technical technical JJ cord-345339-kyboibtq 127 14 difficulties difficulty NNS cord-345339-kyboibtq 127 15 , , , cord-345339-kyboibtq 127 16 it -PRON- PRP cord-345339-kyboibtq 127 17 seems seem VBZ cord-345339-kyboibtq 127 18 remarkable remarkable JJ cord-345339-kyboibtq 127 19 that that IN cord-345339-kyboibtq 127 20 a a DT cord-345339-kyboibtq 127 21 bacterium bacterium NN cord-345339-kyboibtq 127 22 with with IN cord-345339-kyboibtq 127 23 distinct distinct JJ cord-345339-kyboibtq 127 24 morphologic morphologic JJ cord-345339-kyboibtq 127 25 features feature NNS cord-345339-kyboibtq 127 26 could could MD cord-345339-kyboibtq 127 27 have have VB cord-345339-kyboibtq 127 28 eluded elude VBN cord-345339-kyboibtq 127 29 generations generation NNS cord-345339-kyboibtq 127 30 of of IN cord-345339-kyboibtq 127 31 neuropathologists neuropathologist NNS cord-345339-kyboibtq 127 32 . . . cord-345339-kyboibtq 128 1 Furthermore furthermore RB cord-345339-kyboibtq 128 2 , , , cord-345339-kyboibtq 128 3 recent recent JJ cord-345339-kyboibtq 128 4 studies study NNS cord-345339-kyboibtq 128 5 failed fail VBD cord-345339-kyboibtq 128 6 to to TO cord-345339-kyboibtq 128 7 detect detect VB cord-345339-kyboibtq 128 8 Chlamydia Chlamydia NNP cord-345339-kyboibtq 128 9 DNA dna NN cord-345339-kyboibtq 128 10 within within IN cord-345339-kyboibtq 128 11 brain brain NN cord-345339-kyboibtq 128 12 lesions lesion NNS cord-345339-kyboibtq 128 13 obtained obtain VBN cord-345339-kyboibtq 128 14 by by IN cord-345339-kyboibtq 128 15 biopsy biopsy NN cord-345339-kyboibtq 128 16 or or CC cord-345339-kyboibtq 128 17 autopsy autopsy JJ cord-345339-kyboibtq 128 18 of of IN cord-345339-kyboibtq 128 19 MS MS NNP cord-345339-kyboibtq 128 20 patients patient NNS cord-345339-kyboibtq 128 21 [ [ -LRB- cord-345339-kyboibtq 128 22 47 47 CD cord-345339-kyboibtq 128 23 ] ] -RRB- cord-345339-kyboibtq 128 24 . . . cord-345339-kyboibtq 129 1 Thus thus RB cord-345339-kyboibtq 129 2 , , , cord-345339-kyboibtq 129 3 although although IN cord-345339-kyboibtq 129 4 in in IN cord-345339-kyboibtq 129 5 some some DT cord-345339-kyboibtq 129 6 geographical geographical JJ cord-345339-kyboibtq 129 7 areas area NNS cord-345339-kyboibtq 129 8 some some DT cord-345339-kyboibtq 129 9 MS MS NNP cord-345339-kyboibtq 129 10 patients patient NNS cord-345339-kyboibtq 129 11 may may MD cord-345339-kyboibtq 129 12 have have VB cord-345339-kyboibtq 129 13 a a DT cord-345339-kyboibtq 129 14 chronic chronic JJ cord-345339-kyboibtq 129 15 CNS CNS NNP cord-345339-kyboibtq 129 16 chlamydial chlamydial JJ cord-345339-kyboibtq 129 17 infection infection NN cord-345339-kyboibtq 129 18 , , , cord-345339-kyboibtq 129 19 its -PRON- PRP$ cord-345339-kyboibtq 129 20 cause cause NN cord-345339-kyboibtq 129 21 and and CC cord-345339-kyboibtq 129 22 effect effect NN cord-345339-kyboibtq 129 23 role role NN cord-345339-kyboibtq 129 24 in in IN cord-345339-kyboibtq 129 25 MS MS NNP cord-345339-kyboibtq 129 26 is be VBZ cord-345339-kyboibtq 129 27 questionable questionable JJ cord-345339-kyboibtq 129 28 , , , cord-345339-kyboibtq 129 29 because because IN cord-345339-kyboibtq 129 30 the the DT cord-345339-kyboibtq 129 31 pathogen pathogen NN cord-345339-kyboibtq 129 32 is be VBZ cord-345339-kyboibtq 129 33 known know VBN cord-345339-kyboibtq 129 34 to to TO cord-345339-kyboibtq 129 35 infect infect VB cord-345339-kyboibtq 129 36 macrophages macrophage NNS cord-345339-kyboibtq 129 37 and and CC cord-345339-kyboibtq 129 38 could could MD cord-345339-kyboibtq 129 39 secondarily secondarily RB cord-345339-kyboibtq 129 40 gain gain VB cord-345339-kyboibtq 129 41 entrance entrance NN cord-345339-kyboibtq 129 42 into into IN cord-345339-kyboibtq 129 43 the the DT cord-345339-kyboibtq 129 44 CNS CNS NNP cord-345339-kyboibtq 129 45 during during IN cord-345339-kyboibtq 129 46 MS MS NNP cord-345339-kyboibtq 129 47 exacerbations exacerbation NNS cord-345339-kyboibtq 129 48 [ [ -LRB- cord-345339-kyboibtq 129 49 44•• 44•• CD cord-345339-kyboibtq 129 50 ] ] -RRB- cord-345339-kyboibtq 129 51 . . . cord-345339-kyboibtq 130 1 Many many JJ cord-345339-kyboibtq 130 2 details detail NNS cord-345339-kyboibtq 130 3 concerning concern VBG cord-345339-kyboibtq 130 4 the the DT cord-345339-kyboibtq 130 5 mechanism mechanism NN cord-345339-kyboibtq 130 6 of of IN cord-345339-kyboibtq 130 7 myelin myelin JJ cord-345339-kyboibtq 130 8 damage damage NN cord-345339-kyboibtq 130 9 in in IN cord-345339-kyboibtq 130 10 MS MS NNP cord-345339-kyboibtq 130 11 are be VBP cord-345339-kyboibtq 130 12 still still RB cord-345339-kyboibtq 130 13 obscure obscure JJ cord-345339-kyboibtq 130 14 , , , cord-345339-kyboibtq 130 15 but but CC cord-345339-kyboibtq 130 16 putative putative JJ cord-345339-kyboibtq 130 17 models model NNS cord-345339-kyboibtq 130 18 for for IN cord-345339-kyboibtq 130 19 activated activate VBN cord-345339-kyboibtq 130 20 T t NN cord-345339-kyboibtq 130 21 - - HYPH cord-345339-kyboibtq 130 22 cell cell NN cord-345339-kyboibtq 130 23 penetration penetration NN cord-345339-kyboibtq 130 24 of of IN cord-345339-kyboibtq 130 25 the the DT cord-345339-kyboibtq 130 26 CNS CNS NNP cord-345339-kyboibtq 130 27 with with IN cord-345339-kyboibtq 130 28 resultant resultant JJ cord-345339-kyboibtq 130 29 demyelination demyelination NN cord-345339-kyboibtq 130 30 have have VBP cord-345339-kyboibtq 130 31 been be VBN cord-345339-kyboibtq 130 32 put put VBN cord-345339-kyboibtq 130 33 forward forward RB cord-345339-kyboibtq 130 34 [ [ -LRB- cord-345339-kyboibtq 130 35 48 48 CD cord-345339-kyboibtq 130 36 ] ] -RRB- cord-345339-kyboibtq 130 37 . . . cord-345339-kyboibtq 131 1 Thus thus RB cord-345339-kyboibtq 131 2 , , , cord-345339-kyboibtq 131 3 injury injury NN cord-345339-kyboibtq 131 4 might may MD cord-345339-kyboibtq 131 5 be be VB cord-345339-kyboibtq 131 6 due due JJ cord-345339-kyboibtq 131 7 to to IN cord-345339-kyboibtq 131 8 a a DT cord-345339-kyboibtq 131 9 concerted concerted JJ cord-345339-kyboibtq 131 10 effect effect NN cord-345339-kyboibtq 131 11 of of IN cord-345339-kyboibtq 131 12 cytokine cytokine NN cord-345339-kyboibtq 131 13 - - HYPH cord-345339-kyboibtq 131 14 and and CC cord-345339-kyboibtq 131 15 antibody antibody NN cord-345339-kyboibtq 131 16 - - HYPH cord-345339-kyboibtq 131 17 mediated mediate VBN cord-345339-kyboibtq 131 18 injury injury NN cord-345339-kyboibtq 131 19 , , , cord-345339-kyboibtq 131 20 direct direct JJ cord-345339-kyboibtq 131 21 injury injury NN cord-345339-kyboibtq 131 22 to to IN cord-345339-kyboibtq 131 23 oligodendrocytes oligodendrocyte NNS cord-345339-kyboibtq 131 24 by by IN cord-345339-kyboibtq 131 25 CD4 CD4 NNP cord-345339-kyboibtq 131 26 + + CC cord-345339-kyboibtq 131 27 and and CC cord-345339-kyboibtq 131 28 CD8 CD8 NNP cord-345339-kyboibtq 131 29 + + CC cord-345339-kyboibtq 131 30 T T NNP cord-345339-kyboibtq 131 31 cells cell NNS cord-345339-kyboibtq 131 32 , , , cord-345339-kyboibtq 131 33 and and CC cord-345339-kyboibtq 131 34 myelin myelin JJ cord-345339-kyboibtq 131 35 digestion digestion NN cord-345339-kyboibtq 131 36 by by IN cord-345339-kyboibtq 131 37 macrophages macrophage NNS cord-345339-kyboibtq 131 38 . . . cord-345339-kyboibtq 132 1 Naturally naturally RB cord-345339-kyboibtq 132 2 , , , cord-345339-kyboibtq 132 3 a a DT cord-345339-kyboibtq 132 4 heavy heavy JJ cord-345339-kyboibtq 132 5 emphasis emphasis NN cord-345339-kyboibtq 132 6 on on IN cord-345339-kyboibtq 132 7 the the DT cord-345339-kyboibtq 132 8 immune immune JJ cord-345339-kyboibtq 132 9 response response NN cord-345339-kyboibtq 132 10 to to IN cord-345339-kyboibtq 132 11 selfantigens selfantigens NNP cord-345339-kyboibtq 132 12 is be VBZ cord-345339-kyboibtq 132 13 the the DT cord-345339-kyboibtq 132 14 premise premise NN cord-345339-kyboibtq 132 15 of of IN cord-345339-kyboibtq 132 16 these these DT cord-345339-kyboibtq 132 17 models model NNS cord-345339-kyboibtq 132 18 , , , cord-345339-kyboibtq 132 19 but but CC cord-345339-kyboibtq 132 20 such such JJ cord-345339-kyboibtq 132 21 cascades cascade NNS cord-345339-kyboibtq 132 22 could could MD cord-345339-kyboibtq 132 23 still still RB cord-345339-kyboibtq 132 24 be be VB cord-345339-kyboibtq 132 25 easily easily RB cord-345339-kyboibtq 132 26 compatible compatible JJ cord-345339-kyboibtq 132 27 with with IN cord-345339-kyboibtq 132 28 the the DT cord-345339-kyboibtq 132 29 presence presence NN cord-345339-kyboibtq 132 30 of of IN cord-345339-kyboibtq 132 31 microbial microbial JJ cord-345339-kyboibtq 132 32 agents agent NNS cord-345339-kyboibtq 132 33 as as IN cord-345339-kyboibtq 132 34 the the DT cord-345339-kyboibtq 132 35 primary primary JJ cord-345339-kyboibtq 132 36 inciting incite VBG cord-345339-kyboibtq 132 37 events event NNS cord-345339-kyboibtq 132 38 , , , cord-345339-kyboibtq 132 39 or or CC cord-345339-kyboibtq 132 40 as as IN cord-345339-kyboibtq 132 41 modulatory modulatory JJ cord-345339-kyboibtq 132 42 factors factor NNS cord-345339-kyboibtq 132 43 during during IN cord-345339-kyboibtq 132 44 ongoing ongoing JJ cord-345339-kyboibtq 132 45 inflammation inflammation NN cord-345339-kyboibtq 132 46 . . . cord-345339-kyboibtq 133 1 After after IN cord-345339-kyboibtq 133 2 50 50 CD cord-345339-kyboibtq 133 3 years year NNS cord-345339-kyboibtq 133 4 , , , cord-345339-kyboibtq 133 5 no no DT cord-345339-kyboibtq 133 6 breakthrough breakthrough JJ cord-345339-kyboibtq 133 7 evidence evidence NN cord-345339-kyboibtq 133 8 to to TO cord-345339-kyboibtq 133 9 support support VB cord-345339-kyboibtq 133 10 either either CC cord-345339-kyboibtq 133 11 a a DT cord-345339-kyboibtq 133 12 pure pure JJ cord-345339-kyboibtq 133 13 autoimmune autoimmune JJ cord-345339-kyboibtq 133 14 pathogenesis pathogenesis NN cord-345339-kyboibtq 133 15 or or CC cord-345339-kyboibtq 133 16 a a DT cord-345339-kyboibtq 133 17 direct direct JJ cord-345339-kyboibtq 133 18 destructive destructive JJ cord-345339-kyboibtq 133 19 infection infection NN cord-345339-kyboibtq 133 20 of of IN cord-345339-kyboibtq 133 21 white white JJ cord-345339-kyboibtq 133 22 matter matter NN cord-345339-kyboibtq 133 23 components component NNS cord-345339-kyboibtq 133 24 has have VBZ cord-345339-kyboibtq 133 25 become become VBN cord-345339-kyboibtq 133 26 available available JJ cord-345339-kyboibtq 133 27 . . . cord-345339-kyboibtq 134 1 Infection infection NN cord-345339-kyboibtq 134 2 could could MD cord-345339-kyboibtq 134 3 take take VB cord-345339-kyboibtq 134 4 part part NN cord-345339-kyboibtq 134 5 in in IN cord-345339-kyboibtq 134 6 tissue tissue NN cord-345339-kyboibtq 134 7 damage damage NN cord-345339-kyboibtq 134 8 via via IN cord-345339-kyboibtq 134 9 a a DT cord-345339-kyboibtq 134 10 direct direct JJ cord-345339-kyboibtq 134 11 , , , cord-345339-kyboibtq 134 12 PML PML NNP cord-345339-kyboibtq 134 13 - - HYPH cord-345339-kyboibtq 134 14 like like JJ cord-345339-kyboibtq 134 15 infective infective JJ cord-345339-kyboibtq 134 16 process process NN cord-345339-kyboibtq 134 17 . . . cord-345339-kyboibtq 135 1 Although although IN cord-345339-kyboibtq 135 2 it -PRON- PRP cord-345339-kyboibtq 135 3 might may MD cord-345339-kyboibtq 135 4 be be VB cord-345339-kyboibtq 135 5 argued argue VBN cord-345339-kyboibtq 135 6 that that IN cord-345339-kyboibtq 135 7 the the DT cord-345339-kyboibtq 135 8 attempts attempt NNS cord-345339-kyboibtq 135 9 to to TO cord-345339-kyboibtq 135 10 treat treat VB cord-345339-kyboibtq 135 11 MS MS NNP cord-345339-kyboibtq 135 12 with with IN cord-345339-kyboibtq 135 13 intense intense JJ cord-345339-kyboibtq 135 14 immunosuppression immunosuppression NN cord-345339-kyboibtq 135 15 should should MD cord-345339-kyboibtq 135 16 have have VB cord-345339-kyboibtq 135 17 induced induce VBN cord-345339-kyboibtq 135 18 exacerbations exacerbation NNS cord-345339-kyboibtq 135 19 attributed attribute VBN cord-345339-kyboibtq 135 20 to to IN cord-345339-kyboibtq 135 21 enhanced enhance VBN cord-345339-kyboibtq 135 22 viral viral JJ cord-345339-kyboibtq 135 23 proliferation proliferation NN cord-345339-kyboibtq 135 24 ( ( -LRB- cord-345339-kyboibtq 135 25 which which WDT cord-345339-kyboibtq 135 26 they -PRON- PRP cord-345339-kyboibtq 135 27 usually usually RB cord-345339-kyboibtq 135 28 did do VBD cord-345339-kyboibtq 135 29 not not RB cord-345339-kyboibtq 135 30 ) ) -RRB- cord-345339-kyboibtq 135 31 , , , cord-345339-kyboibtq 135 32 there there EX cord-345339-kyboibtq 135 33 are be VBP cord-345339-kyboibtq 135 34 certain certain JJ cord-345339-kyboibtq 135 35 nervous nervous JJ cord-345339-kyboibtq 135 36 system system NN cord-345339-kyboibtq 135 37 persistent persistent JJ cord-345339-kyboibtq 135 38 or or CC cord-345339-kyboibtq 135 39 latent latent JJ cord-345339-kyboibtq 135 40 infections infection NNS cord-345339-kyboibtq 135 41 that that WDT cord-345339-kyboibtq 135 42 are be VBP cord-345339-kyboibtq 135 43 not not RB cord-345339-kyboibtq 135 44 influenced influence VBN cord-345339-kyboibtq 135 45 by by IN cord-345339-kyboibtq 135 46 the the DT cord-345339-kyboibtq 135 47 host host NN cord-345339-kyboibtq 135 48 's 's POS cord-345339-kyboibtq 135 49 immune immune JJ cord-345339-kyboibtq 135 50 state state NN cord-345339-kyboibtq 135 51 [ [ -LRB- cord-345339-kyboibtq 135 52 34 34 CD cord-345339-kyboibtq 135 53 ] ] -RRB- cord-345339-kyboibtq 135 54 . . . cord-345339-kyboibtq 136 1 At at IN cord-345339-kyboibtq 136 2 the the DT cord-345339-kyboibtq 136 3 other other JJ cord-345339-kyboibtq 136 4 end end NN cord-345339-kyboibtq 136 5 , , , cord-345339-kyboibtq 136 6 any any DT cord-345339-kyboibtq 136 7 intercurrent intercurrent NN cord-345339-kyboibtq 136 8 infection infection NN cord-345339-kyboibtq 136 9 may may MD cord-345339-kyboibtq 136 10 induce induce VB cord-345339-kyboibtq 136 11 an an DT cord-345339-kyboibtq 136 12 antimyelin antimyelin JJ cord-345339-kyboibtq 136 13 immune immune JJ cord-345339-kyboibtq 136 14 response response NN cord-345339-kyboibtq 136 15 through through IN cord-345339-kyboibtq 136 16 molecular molecular JJ cord-345339-kyboibtq 136 17 mimicry mimicry NN cord-345339-kyboibtq 136 18 ( ( -LRB- cord-345339-kyboibtq 136 19 ie ie FW cord-345339-kyboibtq 136 20 , , , cord-345339-kyboibtq 136 21 microorganism microorganism NN cord-345339-kyboibtq 136 22 antigens antigen NNS cord-345339-kyboibtq 136 23 that that WDT cord-345339-kyboibtq 136 24 resemble resemble VBP cord-345339-kyboibtq 136 25 myelin myelin NN cord-345339-kyboibtq 136 26 antigens antigen NNS cord-345339-kyboibtq 136 27 that that WDT cord-345339-kyboibtq 136 28 are be VBP cord-345339-kyboibtq 136 29 presented present VBN cord-345339-kyboibtq 136 30 to to IN cord-345339-kyboibtq 136 31 the the DT cord-345339-kyboibtq 136 32 immune immune JJ cord-345339-kyboibtq 136 33 system system NN cord-345339-kyboibtq 136 34 under under IN cord-345339-kyboibtq 136 35 conditions condition NNS cord-345339-kyboibtq 136 36 which which WDT cord-345339-kyboibtq 136 37 favor favor VBP cord-345339-kyboibtq 136 38 breakdown breakdown NN cord-345339-kyboibtq 136 39 of of IN cord-345339-kyboibtq 136 40 self self NN cord-345339-kyboibtq 136 41 tolerance tolerance NN cord-345339-kyboibtq 136 42 followed follow VBN cord-345339-kyboibtq 136 43 by by IN cord-345339-kyboibtq 136 44 the the DT cord-345339-kyboibtq 136 45 myelin myelin NN cord-345339-kyboibtq 136 46 being be VBG cord-345339-kyboibtq 136 47 attacked attack VBN cord-345339-kyboibtq 136 48 by by IN cord-345339-kyboibtq 136 49 the the DT cord-345339-kyboibtq 136 50 newly newly RB cord-345339-kyboibtq 136 51 primed prime VBN cord-345339-kyboibtq 136 52 effector effector NN cord-345339-kyboibtq 136 53 cells cell NNS cord-345339-kyboibtq 136 54 and and CC cord-345339-kyboibtq 136 55 autoantibodies autoantibody NNS cord-345339-kyboibtq 136 56 ) ) -RRB- cord-345339-kyboibtq 137 1 [ [ -LRB- cord-345339-kyboibtq 137 2 49 49 CD cord-345339-kyboibtq 137 3 ] ] -RRB- cord-345339-kyboibtq 137 4 . . . cord-345339-kyboibtq 138 1 Indeed indeed RB cord-345339-kyboibtq 138 2 , , , cord-345339-kyboibtq 138 3 microbial microbial JJ cord-345339-kyboibtq 138 4 epitopes epitope NNS cord-345339-kyboibtq 138 5 resembling resemble VBG cord-345339-kyboibtq 138 6 myelin myelin JJ cord-345339-kyboibtq 138 7 basic basic JJ cord-345339-kyboibtq 138 8 protein protein NN cord-345339-kyboibtq 138 9 have have VBP cord-345339-kyboibtq 138 10 been be VBN cord-345339-kyboibtq 138 11 shown show VBN cord-345339-kyboibtq 138 12 to to TO cord-345339-kyboibtq 138 13 induce induce VB cord-345339-kyboibtq 138 14 experimental experimental JJ cord-345339-kyboibtq 138 15 autoimmune autoimmune JJ cord-345339-kyboibtq 138 16 encephalomyelitis encephalomyelitis NN cord-345339-kyboibtq 138 17 [ [ -LRB- cord-345339-kyboibtq 138 18 50•• 50•• CD cord-345339-kyboibtq 138 19 ] ] -RRB- cord-345339-kyboibtq 138 20 , , , cord-345339-kyboibtq 138 21 and and CC cord-345339-kyboibtq 138 22 fine fine JJ cord-345339-kyboibtq 138 23 specificities specificity NNS cord-345339-kyboibtq 138 24 of of IN cord-345339-kyboibtq 138 25 altered alter VBN cord-345339-kyboibtq 138 26 epitopes epitope NNS cord-345339-kyboibtq 138 27 capable capable JJ cord-345339-kyboibtq 138 28 of of IN cord-345339-kyboibtq 138 29 inhibiting inhibit VBG cord-345339-kyboibtq 138 30 the the DT cord-345339-kyboibtq 138 31 self self NN cord-345339-kyboibtq 138 32 response response NN cord-345339-kyboibtq 138 33 are be VBP cord-345339-kyboibtq 138 34 under under IN cord-345339-kyboibtq 138 35 study study NN cord-345339-kyboibtq 138 36 . . . cord-345339-kyboibtq 139 1 However however RB cord-345339-kyboibtq 139 2 , , , cord-345339-kyboibtq 139 3 Guillain Guillain NNP cord-345339-kyboibtq 139 4 - - HYPH cord-345339-kyboibtq 139 5 Barre Barre NNP cord-345339-kyboibtq 139 6 syndrome syndrome NN cord-345339-kyboibtq 139 7 and and CC cord-345339-kyboibtq 139 8 paraneoplastic paraneoplastic JJ cord-345339-kyboibtq 139 9 disorders disorder NNS cord-345339-kyboibtq 139 10 in in IN cord-345339-kyboibtq 139 11 which which WDT cord-345339-kyboibtq 139 12 molecular molecular JJ cord-345339-kyboibtq 139 13 mimicry mimicry NN cord-345339-kyboibtq 139 14 is be VBZ cord-345339-kyboibtq 139 15 thought think VBN cord-345339-kyboibtq 139 16 to to TO cord-345339-kyboibtq 139 17 play play VB cord-345339-kyboibtq 139 18 a a DT cord-345339-kyboibtq 139 19 central central JJ cord-345339-kyboibtq 139 20 role role NN cord-345339-kyboibtq 139 21 are be VBP cord-345339-kyboibtq 139 22 either either CC cord-345339-kyboibtq 139 23 mainly mainly RB cord-345339-kyboibtq 139 24 monophasic monophasic JJ cord-345339-kyboibtq 139 25 or or CC cord-345339-kyboibtq 139 26 subacute subacute JJ cord-345339-kyboibtq 139 27 progressive progressive JJ cord-345339-kyboibtq 139 28 disorders disorder NNS cord-345339-kyboibtq 139 29 , , , cord-345339-kyboibtq 139 30 not not RB cord-345339-kyboibtq 139 31 characterized characterize VBN cord-345339-kyboibtq 139 32 by by IN cord-345339-kyboibtq 139 33 frequent frequent JJ cord-345339-kyboibtq 139 34 relapses relapse NNS cord-345339-kyboibtq 139 35 . . . cord-345339-kyboibtq 140 1 Additionally additionally RB cord-345339-kyboibtq 140 2 , , , cord-345339-kyboibtq 140 3 some some DT cord-345339-kyboibtq 140 4 viruses virus NNS cord-345339-kyboibtq 140 5 may may MD cord-345339-kyboibtq 140 6 act act VB cord-345339-kyboibtq 140 7 as as IN cord-345339-kyboibtq 140 8 superantigens superantigens NNP cord-345339-kyboibtq 140 9 [ [ -LRB- cord-345339-kyboibtq 140 10 40 40 CD cord-345339-kyboibtq 140 11 ] ] -RRB- cord-345339-kyboibtq 140 12 that that WDT cord-345339-kyboibtq 140 13 bind bind VBP cord-345339-kyboibtq 140 14 outside outside IN cord-345339-kyboibtq 140 15 the the DT cord-345339-kyboibtq 140 16 antigen antigen NN cord-345339-kyboibtq 140 17 grove grove NNP cord-345339-kyboibtq 140 18 , , , cord-345339-kyboibtq 140 19 and and CC cord-345339-kyboibtq 140 20 activate activate VB cord-345339-kyboibtq 140 21 whole whole JJ cord-345339-kyboibtq 140 22 classes class NNS cord-345339-kyboibtq 140 23 of of IN cord-345339-kyboibtq 140 24 T t NN cord-345339-kyboibtq 140 25 cells cell NNS cord-345339-kyboibtq 140 26 , , , cord-345339-kyboibtq 140 27 including include VBG cord-345339-kyboibtq 140 28 autoreactive autoreactive JJ cord-345339-kyboibtq 140 29 T t NN cord-345339-kyboibtq 140 30 cells cell NNS cord-345339-kyboibtq 140 31 specific specific JJ cord-345339-kyboibtq 140 32 for for IN cord-345339-kyboibtq 140 33 myelin myelin NN cord-345339-kyboibtq 140 34 antigen(s antigen(s NNP cord-345339-kyboibtq 140 35 ) ) -RRB- cord-345339-kyboibtq 140 36 , , , cord-345339-kyboibtq 140 37 which which WDT cord-345339-kyboibtq 140 38 once once RB cord-345339-kyboibtq 140 39 activated activate VBD cord-345339-kyboibtq 140 40 may may MD cord-345339-kyboibtq 140 41 cross cross VB cord-345339-kyboibtq 140 42 the the DT cord-345339-kyboibtq 140 43 blood blood NN cord-345339-kyboibtq 140 44 - - HYPH cord-345339-kyboibtq 140 45 brain brain NN cord-345339-kyboibtq 140 46 barrier barrier NN cord-345339-kyboibtq 140 47 . . . cord-345339-kyboibtq 141 1 There there EX cord-345339-kyboibtq 141 2 are be VBP cord-345339-kyboibtq 141 3 also also RB cord-345339-kyboibtq 141 4 possibilities possibility NNS cord-345339-kyboibtq 141 5 that that WDT cord-345339-kyboibtq 141 6 combine combine VBP cord-345339-kyboibtq 141 7 these these DT cord-345339-kyboibtq 141 8 two two CD cord-345339-kyboibtq 141 9 extremes extreme NNS cord-345339-kyboibtq 141 10 . . . cord-345339-kyboibtq 142 1 Theoretically theoretically RB cord-345339-kyboibtq 142 2 , , , cord-345339-kyboibtq 142 3 latent latent JJ cord-345339-kyboibtq 142 4 viral viral JJ cord-345339-kyboibtq 142 5 infection infection NN cord-345339-kyboibtq 142 6 of of IN cord-345339-kyboibtq 142 7 oligodendrocytes oligodendrocyte NNS cord-345339-kyboibtq 142 8 ( ( -LRB- cord-345339-kyboibtq 142 9 capable capable JJ cord-345339-kyboibtq 142 10 of of IN cord-345339-kyboibtq 142 11 frequent frequent JJ cord-345339-kyboibtq 142 12 mutations mutation NNS cord-345339-kyboibtq 142 13 ) ) -RRB- cord-345339-kyboibtq 142 14 may may MD cord-345339-kyboibtq 142 15 occasionally occasionally RB cord-345339-kyboibtq 142 16 express express VB cord-345339-kyboibtq 142 17 novel novel JJ cord-345339-kyboibtq 142 18 gene gene NN cord-345339-kyboibtq 142 19 products product NNS cord-345339-kyboibtq 142 20 that that WDT cord-345339-kyboibtq 142 21 will will MD cord-345339-kyboibtq 142 22 be be VB cord-345339-kyboibtq 142 23 recognized recognize VBN cord-345339-kyboibtq 142 24 as as IN cord-345339-kyboibtq 142 25 foreign foreign JJ cord-345339-kyboibtq 142 26 , , , cord-345339-kyboibtq 142 27 and and CC cord-345339-kyboibtq 142 28 the the DT cord-345339-kyboibtq 142 29 immune immune JJ cord-345339-kyboibtq 142 30 system system NN cord-345339-kyboibtq 142 31 will will MD cord-345339-kyboibtq 142 32 eventually eventually RB cord-345339-kyboibtq 142 33 mount mount VB cord-345339-kyboibtq 142 34 an an DT cord-345339-kyboibtq 142 35 inflammatory inflammatory JJ cord-345339-kyboibtq 142 36 response response NN cord-345339-kyboibtq 142 37 with with IN cord-345339-kyboibtq 142 38 extensive extensive JJ cord-345339-kyboibtq 142 39 local local JJ cord-345339-kyboibtq 142 40 damage damage NN cord-345339-kyboibtq 142 41 . . . cord-345339-kyboibtq 143 1 The the DT cord-345339-kyboibtq 143 2 relative relative JJ cord-345339-kyboibtq 143 3 immune immune JJ cord-345339-kyboibtq 143 4 privilege privilege NN cord-345339-kyboibtq 143 5 of of IN cord-345339-kyboibtq 143 6 the the DT cord-345339-kyboibtq 143 7 CNS CNS NNP cord-345339-kyboibtq 143 8 may may MD cord-345339-kyboibtq 143 9 support support VB cord-345339-kyboibtq 143 10 such such JJ cord-345339-kyboibtq 143 11 damage damage NN cord-345339-kyboibtq 143 12 , , , cord-345339-kyboibtq 143 13 because because IN cord-345339-kyboibtq 143 14 single single JJ cord-345339-kyboibtq 143 15 cells cell NNS cord-345339-kyboibtq 143 16 harboring harbor VBG cord-345339-kyboibtq 143 17 the the DT cord-345339-kyboibtq 143 18 virus virus NN cord-345339-kyboibtq 143 19 will will MD cord-345339-kyboibtq 143 20 remain remain VB cord-345339-kyboibtq 143 21 undetected undetected JJ cord-345339-kyboibtq 143 22 and and CC cord-345339-kyboibtq 143 23 the the DT cord-345339-kyboibtq 143 24 immune immune JJ cord-345339-kyboibtq 143 25 response response NN cord-345339-kyboibtq 143 26 delayed delay VBN cord-345339-kyboibtq 143 27 , , , cord-345339-kyboibtq 143 28 enabling enable VBG cord-345339-kyboibtq 143 29 tissue tissue NN cord-345339-kyboibtq 143 30 alteration alteration NN cord-345339-kyboibtq 143 31 to to TO cord-345339-kyboibtq 143 32 spread spread VB cord-345339-kyboibtq 143 33 locally locally RB cord-345339-kyboibtq 143 34 , , , cord-345339-kyboibtq 143 35 causing cause VBG cord-345339-kyboibtq 143 36 a a DT cord-345339-kyboibtq 143 37 more more RBR cord-345339-kyboibtq 143 38 extensive extensive JJ cord-345339-kyboibtq 143 39 response response NN cord-345339-kyboibtq 143 40 later later RB cord-345339-kyboibtq 143 41 . . . cord-345339-kyboibtq 144 1 Other other JJ cord-345339-kyboibtq 144 2 possibilities possibility NNS cord-345339-kyboibtq 144 3 are be VBP cord-345339-kyboibtq 144 4 even even RB cord-345339-kyboibtq 144 5 more more RBR cord-345339-kyboibtq 144 6 hypothetical hypothetical JJ cord-345339-kyboibtq 144 7 . . . cord-345339-kyboibtq 145 1 For for IN cord-345339-kyboibtq 145 2 instance instance NN cord-345339-kyboibtq 145 3 , , , cord-345339-kyboibtq 145 4 double double JJ cord-345339-kyboibtq 145 5 infections infection NNS cord-345339-kyboibtq 145 6 , , , cord-345339-kyboibtq 145 7 in in IN cord-345339-kyboibtq 145 8 which which WDT cord-345339-kyboibtq 145 9 products product NNS cord-345339-kyboibtq 145 10 of of IN cord-345339-kyboibtq 145 11 one one CD cord-345339-kyboibtq 145 12 infectious infectious JJ cord-345339-kyboibtq 145 13 process process NN cord-345339-kyboibtq 145 14 enhance enhance VBP cord-345339-kyboibtq 145 15 a a DT cord-345339-kyboibtq 145 16 nonspecific nonspecific JJ cord-345339-kyboibtq 145 17 or or CC cord-345339-kyboibtq 145 18 specific specific JJ cord-345339-kyboibtq 145 19 responses response NNS cord-345339-kyboibtq 145 20 to to IN cord-345339-kyboibtq 145 21 a a DT cord-345339-kyboibtq 145 22 second second JJ cord-345339-kyboibtq 145 23 or or CC cord-345339-kyboibtq 145 24 a a DT cord-345339-kyboibtq 145 25 latent latent JJ cord-345339-kyboibtq 145 26 pathogen pathogen NN cord-345339-kyboibtq 145 27 , , , cord-345339-kyboibtq 145 28 might may MD cord-345339-kyboibtq 145 29 be be VB cord-345339-kyboibtq 145 30 also also RB cord-345339-kyboibtq 145 31 considered consider VBN cord-345339-kyboibtq 145 32 . . . cord-345339-kyboibtq 146 1 The the DT cord-345339-kyboibtq 146 2 answers answer NNS cord-345339-kyboibtq 146 3 are be VBP cord-345339-kyboibtq 146 4 probably probably RB cord-345339-kyboibtq 146 5 more more RBR cord-345339-kyboibtq 146 6 complex complex JJ cord-345339-kyboibtq 146 7 and and CC cord-345339-kyboibtq 146 8 multifactorial multifactorial JJ cord-345339-kyboibtq 146 9 . . . cord-345339-kyboibtq 147 1 The the DT cord-345339-kyboibtq 147 2 infection infection NN cord-345339-kyboibtq 147 3 could could MD cord-345339-kyboibtq 147 4 be be VB cord-345339-kyboibtq 147 5 the the DT cord-345339-kyboibtq 147 6 primary primary JJ cord-345339-kyboibtq 147 7 etiology etiology NN cord-345339-kyboibtq 147 8 , , , cord-345339-kyboibtq 147 9 but but CC cord-345339-kyboibtq 147 10 an an DT cord-345339-kyboibtq 147 11 immune immune NN cord-345339-kyboibtq 147 12 - - HYPH cord-345339-kyboibtq 147 13 mediated mediate VBN cord-345339-kyboibtq 147 14 response response NN cord-345339-kyboibtq 147 15 will will MD cord-345339-kyboibtq 147 16 play play VB cord-345339-kyboibtq 147 17 an an DT cord-345339-kyboibtq 147 18 important important JJ cord-345339-kyboibtq 147 19 pathogenic pathogenic JJ cord-345339-kyboibtq 147 20 role role NN cord-345339-kyboibtq 147 21 . . . cord-345339-kyboibtq 148 1 Alternatively alternatively RB cord-345339-kyboibtq 148 2 , , , cord-345339-kyboibtq 148 3 if if IN cord-345339-kyboibtq 148 4 MS MS NNP cord-345339-kyboibtq 148 5 is be VBZ cord-345339-kyboibtq 148 6 indeed indeed RB cord-345339-kyboibtq 148 7 a a DT cord-345339-kyboibtq 148 8 syndrome syndrome NN cord-345339-kyboibtq 148 9 , , , cord-345339-kyboibtq 148 10 inter inter JJ cord-345339-kyboibtq 148 11 - - JJ cord-345339-kyboibtq 148 12 patient patient JJ cord-345339-kyboibtq 148 13 differences difference NNS cord-345339-kyboibtq 148 14 may may MD cord-345339-kyboibtq 148 15 account account VB cord-345339-kyboibtq 148 16 for for IN cord-345339-kyboibtq 148 17 the the DT cord-345339-kyboibtq 148 18 difficulty difficulty NN cord-345339-kyboibtq 148 19 in in IN cord-345339-kyboibtq 148 20 establishing establish VBG cord-345339-kyboibtq 148 21 a a DT cord-345339-kyboibtq 148 22 unifying unifying JJ cord-345339-kyboibtq 148 23 hypothesis hypothesis NN cord-345339-kyboibtq 148 24 on on IN cord-345339-kyboibtq 148 25 MS MS NNP cord-345339-kyboibtq 148 26 etiology etiology NN cord-345339-kyboibtq 148 27 . . . cord-345339-kyboibtq 149 1 This this DT cord-345339-kyboibtq 149 2 is be VBZ cord-345339-kyboibtq 149 3 supported support VBN cord-345339-kyboibtq 149 4 by by IN cord-345339-kyboibtq 149 5 a a DT cord-345339-kyboibtq 149 6 recent recent JJ cord-345339-kyboibtq 149 7 pathologic pathologic JJ cord-345339-kyboibtq 149 8 study study NN cord-345339-kyboibtq 149 9 [ [ -LRB- cord-345339-kyboibtq 149 10 4•• 4•• CD cord-345339-kyboibtq 149 11 ] ] -RRB- cord-345339-kyboibtq 149 12 , , , cord-345339-kyboibtq 149 13 where where WRB cord-345339-kyboibtq 149 14 four four CD cord-345339-kyboibtq 149 15 different different JJ cord-345339-kyboibtq 149 16 demyelination demyelination NN cord-345339-kyboibtq 149 17 patterns pattern NNS cord-345339-kyboibtq 149 18 , , , cord-345339-kyboibtq 149 19 two two CD cord-345339-kyboibtq 149 20 showing show VBG cord-345339-kyboibtq 149 21 evidence evidence NN cord-345339-kyboibtq 149 22 for for IN cord-345339-kyboibtq 149 23 a a DT cord-345339-kyboibtq 149 24 viral viral JJ cord-345339-kyboibtq 149 25 - - HYPH cord-345339-kyboibtq 149 26 or or CC cord-345339-kyboibtq 149 27 toxin toxin NN cord-345339-kyboibtq 149 28 - - HYPH cord-345339-kyboibtq 149 29 mediated mediate VBN cord-345339-kyboibtq 149 30 oligodendrocytopathy oligodendrocytopathy NN cord-345339-kyboibtq 149 31 , , , cord-345339-kyboibtq 149 32 are be VBP cord-345339-kyboibtq 149 33 suggested suggest VBN cord-345339-kyboibtq 149 34 . . . cord-345339-kyboibtq 150 1 At at IN cord-345339-kyboibtq 150 2 any any DT cord-345339-kyboibtq 150 3 rate rate NN cord-345339-kyboibtq 150 4 , , , cord-345339-kyboibtq 150 5 non non JJ cord-345339-kyboibtq 150 6 - - JJ cord-345339-kyboibtq 150 7 unifying unifying JJ cord-345339-kyboibtq 150 8 approaches approach NNS cord-345339-kyboibtq 150 9 aimed aim VBN cord-345339-kyboibtq 150 10 at at IN cord-345339-kyboibtq 150 11 splitting split VBG cord-345339-kyboibtq 150 12 the the DT cord-345339-kyboibtq 150 13 syndrome syndrome NN cord-345339-kyboibtq 150 14 of of IN cord-345339-kyboibtq 150 15 MS MS NNP cord-345339-kyboibtq 150 16 into into IN cord-345339-kyboibtq 150 17 distinct distinct JJ cord-345339-kyboibtq 150 18 entities entity NNS cord-345339-kyboibtq 150 19 are be VBP cord-345339-kyboibtq 150 20 probably probably RB cord-345339-kyboibtq 150 21 necessary necessary JJ cord-345339-kyboibtq 150 22 to to TO cord-345339-kyboibtq 150 23 unravel unravel VB cord-345339-kyboibtq 150 24 the the DT cord-345339-kyboibtq 150 25 mystery mystery NN cord-345339-kyboibtq 150 26 of of IN cord-345339-kyboibtq 150 27 MS MS NNP cord-345339-kyboibtq 150 28 etiology etiology NN cord-345339-kyboibtq 150 29 . . . cord-345339-kyboibtq 151 1 We -PRON- PRP cord-345339-kyboibtq 151 2 have have VBP cord-345339-kyboibtq 151 3 provided provide VBN cord-345339-kyboibtq 151 4 the the DT cord-345339-kyboibtq 151 5 data datum NNS cord-345339-kyboibtq 151 6 in in IN cord-345339-kyboibtq 151 7 favor favor NN cord-345339-kyboibtq 151 8 of of IN cord-345339-kyboibtq 151 9 an an DT cord-345339-kyboibtq 151 10 infectious infectious JJ cord-345339-kyboibtq 151 11 etiology etiology NN cord-345339-kyboibtq 151 12 of of IN cord-345339-kyboibtq 151 13 MS MS NNP cord-345339-kyboibtq 151 14 . . . cord-345339-kyboibtq 152 1 However however RB cord-345339-kyboibtq 152 2 , , , cord-345339-kyboibtq 152 3 as as IN cord-345339-kyboibtq 152 4 of of IN cord-345339-kyboibtq 152 5 today today NN cord-345339-kyboibtq 152 6 , , , cord-345339-kyboibtq 152 7 there there EX cord-345339-kyboibtq 152 8 is be VBZ cord-345339-kyboibtq 152 9 still still RB cord-345339-kyboibtq 152 10 no no DT cord-345339-kyboibtq 152 11 evidence evidence NN cord-345339-kyboibtq 152 12 to to TO cord-345339-kyboibtq 152 13 incriminate incriminate VB cord-345339-kyboibtq 152 14 a a DT cord-345339-kyboibtq 152 15 specific specific JJ cord-345339-kyboibtq 152 16 pathogen pathogen NN cord-345339-kyboibtq 152 17 . . . cord-345339-kyboibtq 153 1 The the DT cord-345339-kyboibtq 153 2 hunt hunt NN cord-345339-kyboibtq 153 3 is be VBZ cord-345339-kyboibtq 153 4 still still RB cord-345339-kyboibtq 153 5 on on RB cord-345339-kyboibtq 153 6 , , , cord-345339-kyboibtq 153 7 and and CC cord-345339-kyboibtq 153 8 until until IN cord-345339-kyboibtq 153 9 the the DT cord-345339-kyboibtq 153 10 causative causative JJ cord-345339-kyboibtq 153 11 agent agent NN cord-345339-kyboibtq 153 12 and and CC cord-345339-kyboibtq 153 13 the the DT cord-345339-kyboibtq 153 14 destructive destructive JJ cord-345339-kyboibtq 153 15 scheme scheme NN cord-345339-kyboibtq 153 16 are be VBP cord-345339-kyboibtq 153 17 be be VB cord-345339-kyboibtq 153 18 exposed expose VBN cord-345339-kyboibtq 153 19 , , , cord-345339-kyboibtq 153 20 the the DT cord-345339-kyboibtq 153 21 neurologic neurologic JJ cord-345339-kyboibtq 153 22 scientific scientific JJ cord-345339-kyboibtq 153 23 and and CC cord-345339-kyboibtq 153 24 clinical clinical JJ cord-345339-kyboibtq 153 25 community community NN cord-345339-kyboibtq 153 26 will will MD cord-345339-kyboibtq 153 27 not not RB cord-345339-kyboibtq 153 28 give give VB cord-345339-kyboibtq 153 29 up up RP cord-345339-kyboibtq 153 30 . . . cord-345339-kyboibtq 154 1 Multiple multiple JJ cord-345339-kyboibtq 154 2 sclerosis sclerosis NN cord-345339-kyboibtq 154 3 - - HYPH cord-345339-kyboibtq 154 4 in in IN cord-345339-kyboibtq 154 5 need need NN cord-345339-kyboibtq 154 6 of of IN cord-345339-kyboibtq 154 7 critical critical JJ cord-345339-kyboibtq 154 8 reappraisal reappraisal NN cord-345339-kyboibtq 155 1 A a DT cord-345339-kyboibtq 155 2 critical critical JJ cord-345339-kyboibtq 155 3 review review NN cord-345339-kyboibtq 155 4 of of IN cord-345339-kyboibtq 155 5 the the DT cord-345339-kyboibtq 155 6 immunologic immunologic JJ cord-345339-kyboibtq 155 7 hypothesis hypothesis NN cord-345339-kyboibtq 155 8 of of IN cord-345339-kyboibtq 155 9 multiple multiple JJ cord-345339-kyboibtq 155 10 sclerosis sclerosis NN cord-345339-kyboibtq 155 11 Problems problem NNS cord-345339-kyboibtq 155 12 of of IN cord-345339-kyboibtq 155 13 experimental experimental JJ cord-345339-kyboibtq 155 14 trials trial NNS cord-345339-kyboibtq 155 15 of of IN cord-345339-kyboibtq 155 16 therapy therapy NN cord-345339-kyboibtq 155 17 in in IN cord-345339-kyboibtq 155 18 multiple multiple JJ cord-345339-kyboibtq 155 19 sclerosis sclerosis NN cord-345339-kyboibtq 155 20 : : : cord-345339-kyboibtq 156 1 report report NN cord-345339-kyboibtq 156 2 by by IN cord-345339-kyboibtq 156 3 the the DT cord-345339-kyboibtq 156 4 panel panel NN cord-345339-kyboibtq 156 5 on on IN cord-345339-kyboibtq 156 6 the the DT cord-345339-kyboibtq 156 7 evaluation evaluation NN cord-345339-kyboibtq 156 8 of of IN cord-345339-kyboibtq 156 9 experimental experimental JJ cord-345339-kyboibtq 156 10 trials trial NNS cord-345339-kyboibtq 156 11 of of IN cord-345339-kyboibtq 156 12 therapy therapy NN cord-345339-kyboibtq 156 13 in in IN cord-345339-kyboibtq 156 14 multiple multiple JJ cord-345339-kyboibtq 156 15 sclerosis sclerosis NN cord-345339-kyboibtq 156 16 Sclerose Sclerose NNP cord-345339-kyboibtq 156 17 en en IN cord-345339-kyboibtq 156 18 plaques plaque NNS cord-345339-kyboibtq 156 19 et et IN cord-345339-kyboibtq 156 20 maladies malady NNS cord-345339-kyboibtq 157 1 infectieuses infectieuses NNPS cord-345339-kyboibtq 157 2 Heterogeneity Heterogeneity NNP cord-345339-kyboibtq 157 3 of of IN cord-345339-kyboibtq 157 4 multiple multiple JJ cord-345339-kyboibtq 157 5 sclerosis sclerosis NN cord-345339-kyboibtq 157 6 lesions lesion NNS cord-345339-kyboibtq 157 7 : : : cord-345339-kyboibtq 157 8 implications implication NNS cord-345339-kyboibtq 157 9 for for IN cord-345339-kyboibtq 157 10 the the DT cord-345339-kyboibtq 157 11 pathogenesis pathogenesis NN cord-345339-kyboibtq 157 12 of of IN cord-345339-kyboibtq 157 13 demyelination demyelination NN cord-345339-kyboibtq 158 1 A a DT cord-345339-kyboibtq 158 2 new new JJ cord-345339-kyboibtq 158 3 look look NN cord-345339-kyboibtq 158 4 at at IN cord-345339-kyboibtq 158 5 multiple multiple JJ cord-345339-kyboibtq 158 6 sclerosis sclerosis NN cord-345339-kyboibtq 158 7 ( ( -LRB- cord-345339-kyboibtq 158 8 MS MS NNP cord-345339-kyboibtq 158 9 ) ) -RRB- cord-345339-kyboibtq 158 10 pathology pathology NN cord-345339-kyboibtq 158 11 supporting support VBG cord-345339-kyboibtq 158 12 the the DT cord-345339-kyboibtq 158 13 nonuniformity nonuniformity NN cord-345339-kyboibtq 158 14 of of IN cord-345339-kyboibtq 158 15 the the DT cord-345339-kyboibtq 158 16 condition condition NN cord-345339-kyboibtq 158 17 and and CC cord-345339-kyboibtq 158 18 the the DT cord-345339-kyboibtq 158 19 concept concept NN cord-345339-kyboibtq 158 20 that that IN cord-345339-kyboibtq 158 21 MS MS NNP cord-345339-kyboibtq 158 22 is be VBZ cord-345339-kyboibtq 158 23 a a DT cord-345339-kyboibtq 158 24 syndrome syndrome NN cord-345339-kyboibtq 158 25 Epidemiologic epidemiologic JJ cord-345339-kyboibtq 158 26 evidence evidence NN cord-345339-kyboibtq 158 27 for for IN cord-345339-kyboibtq 158 28 multiple multiple JJ cord-345339-kyboibtq 158 29 sclerosis sclerosis NN cord-345339-kyboibtq 158 30 as as IN cord-345339-kyboibtq 158 31 an an DT cord-345339-kyboibtq 158 32 infection infection NN cord-345339-kyboibtq 158 33 Epidemiologic Epidemiologic NNP cord-345339-kyboibtq 158 34 studies study NNS cord-345339-kyboibtq 158 35 of of IN cord-345339-kyboibtq 158 36 measles measle NNS cord-345339-kyboibtq 158 37 , , , cord-345339-kyboibtq 158 38 measles measle NNS cord-345339-kyboibtq 158 39 vaccine vaccine NN cord-345339-kyboibtq 158 40 , , , cord-345339-kyboibtq 158 41 and and CC cord-345339-kyboibtq 158 42 subacute subacute JJ cord-345339-kyboibtq 158 43 sclerosing sclerosing NN cord-345339-kyboibtq 158 44 panencephalitis panencephalitis NNP cord-345339-kyboibtq 158 45 Sobre Sobre NNP cord-345339-kyboibtq 158 46 la la NNP cord-345339-kyboibtq 159 1 clinical clinical JJ cord-345339-kyboibtq 159 2 de de FW cord-345339-kyboibtq 159 3 la la FW cord-345339-kyboibtq 159 4 escleroisis escleroisis NNP cord-345339-kyboibtq 159 5 multiple multiple JJ cord-345339-kyboibtq 159 6 Conugal conugal JJ cord-345339-kyboibtq 159 7 multiple multiple JJ cord-345339-kyboibtq 159 8 sclerosis sclerosis NN cord-345339-kyboibtq 159 9 . . . cord-345339-kyboibtq 160 1 Immunogenetic immunogenetic JJ cord-345339-kyboibtq 160 2 characterization characterization NN cord-345339-kyboibtq 160 3 and and CC cord-345339-kyboibtq 160 4 analysis analysis NN cord-345339-kyboibtq 160 5 of of IN cord-345339-kyboibtq 160 6 T T NNP cord-345339-kyboibtq 160 7 - - HYPH cord-345339-kyboibtq 160 8 and and CC cord-345339-kyboibtq 160 9 B b NN cord-345339-kyboibtq 160 10 - - HYPH cord-345339-kyboibtq 160 11 cell cell NN cord-345339-kyboibtq 160 12 reactivity reactivity NN cord-345339-kyboibtq 160 13 to to IN cord-345339-kyboibtq 160 14 myelin myelin NN cord-345339-kyboibtq 160 15 protein protein NN cord-345339-kyboibtq 160 16 Familial familial JJ cord-345339-kyboibtq 160 17 and and CC cord-345339-kyboibtq 160 18 conjugal conjugal JJ cord-345339-kyboibtq 160 19 multiple multiple JJ cord-345339-kyboibtq 160 20 sclerosis sclerosis NN cord-345339-kyboibtq 160 21 Multiple multiple JJ cord-345339-kyboibtq 160 22 sclerosis sclerosis NN cord-345339-kyboibtq 160 23 in in IN cord-345339-kyboibtq 160 24 research research NN cord-345339-kyboibtq 160 25 workers worker NNS cord-345339-kyboibtq 160 26 studying study VBG cord-345339-kyboibtq 160 27 swayback swayback NN cord-345339-kyboibtq 160 28 in in IN cord-345339-kyboibtq 160 29 lambs lamb NNS cord-345339-kyboibtq 160 30 : : : cord-345339-kyboibtq 160 31 an an DT cord-345339-kyboibtq 160 32 updated update VBN cord-345339-kyboibtq 160 33 report report NN cord-345339-kyboibtq 161 1 The the DT cord-345339-kyboibtq 161 2 virology virology NN cord-345339-kyboibtq 161 3 of of IN cord-345339-kyboibtq 161 4 demyelinating demyelinate VBG cord-345339-kyboibtq 161 5 diseases disease NNS cord-345339-kyboibtq 161 6 Interferon interferon NN cord-345339-kyboibtq 161 7 beta beta NN cord-345339-kyboibtq 161 8 1b 1b NN cord-345339-kyboibtq 161 9 is be VBZ cord-345339-kyboibtq 161 10 effective effective JJ cord-345339-kyboibtq 161 11 in in IN cord-345339-kyboibtq 161 12 relapsing relapse VBG cord-345339-kyboibtq 161 13 - - HYPH cord-345339-kyboibtq 161 14 remitting remit VBG cord-345339-kyboibtq 161 15 multiple multiple JJ cord-345339-kyboibtq 161 16 sclerosis sclerosis NN cord-345339-kyboibtq 161 17 . . . cord-345339-kyboibtq 162 1 I. i. LS cord-345339-kyboibtq 162 2 Clinical clinical JJ cord-345339-kyboibtq 162 3 results result NNS cord-345339-kyboibtq 162 4 of of IN cord-345339-kyboibtq 162 5 a a DT cord-345339-kyboibtq 162 6 multicenter multicenter NN cord-345339-kyboibtq 162 7 , , , cord-345339-kyboibtq 162 8 randomized randomized JJ cord-345339-kyboibtq 162 9 , , , cord-345339-kyboibtq 162 10 double double JJ cord-345339-kyboibtq 162 11 blind blind JJ cord-345339-kyboibtq 162 12 , , , cord-345339-kyboibtq 162 13 placebo placebo NN cord-345339-kyboibtq 162 14 - - HYPH cord-345339-kyboibtq 162 15 controlled control VBN cord-345339-kyboibtq 162 16 trial trial NN cord-345339-kyboibtq 162 17 Impact Impact NNP cord-345339-kyboibtq 162 18 of of IN cord-345339-kyboibtq 162 19 interferon interferon NN cord-345339-kyboibtq 162 20 beta-1a beta-1a NNP cord-345339-kyboibtq 162 21 on on IN cord-345339-kyboibtq 162 22 neurologic neurologic JJ cord-345339-kyboibtq 162 23 disability disability NN cord-345339-kyboibtq 162 24 in in IN cord-345339-kyboibtq 162 25 relapsing relapse VBG cord-345339-kyboibtq 162 26 multiple multiple JJ cord-345339-kyboibtq 162 27 sclerosis sclerosis NN cord-345339-kyboibtq 162 28 . . . cord-345339-kyboibtq 163 1 The the DT cord-345339-kyboibtq 163 2 Multiple Multiple NNP cord-345339-kyboibtq 163 3 Sclerosis Sclerosis NNP cord-345339-kyboibtq 163 4 Collaborative Collaborative NNP cord-345339-kyboibtq 163 5 Research Research NNP cord-345339-kyboibtq 163 6 Group Group NNP cord-345339-kyboibtq 163 7 ( ( -LRB- cord-345339-kyboibtq 163 8 MSCRG MSCRG NNP cord-345339-kyboibtq 163 9 ) ) -RRB- cord-345339-kyboibtq 163 10 PRISM PRISM NNP cord-345339-kyboibtq 163 11 ( ( -LRB- cord-345339-kyboibtq 163 12 Prevention Prevention NNP cord-345339-kyboibtq 163 13 of of IN cord-345339-kyboibtq 163 14 Relapses Relapses NNPS cord-345339-kyboibtq 163 15 and and CC cord-345339-kyboibtq 163 16 Disability Disability NNP cord-345339-kyboibtq 163 17 by by IN cord-345339-kyboibtq 163 18 Interferon Interferon NNP cord-345339-kyboibtq 163 19 b-1a b-1a NN cord-345339-kyboibtq 163 20 Subcutaneously Subcutaneously NNP cord-345339-kyboibtq 163 21 in in IN cord-345339-kyboibtq 163 22 Multiple Multiple NNP cord-345339-kyboibtq 163 23 Sclerosis Sclerosis NNP cord-345339-kyboibtq 163 24 ) ) -RRB- cord-345339-kyboibtq 163 25 Study Study NNP cord-345339-kyboibtq 163 26 Group Group NNP cord-345339-kyboibtq 163 27 . . . cord-345339-kyboibtq 163 28 : : : cord-345339-kyboibtq 164 1 Randomized randomized JJ cord-345339-kyboibtq 164 2 double double JJ cord-345339-kyboibtq 164 3 blind blind JJ cord-345339-kyboibtq 164 4 placebo placebo NN cord-345339-kyboibtq 164 5 controlled control VBN cord-345339-kyboibtq 164 6 study study NN cord-345339-kyboibtq 164 7 of of IN cord-345339-kyboibtq 164 8 interferon interferon NNP cord-345339-kyboibtq 164 9 b-1a b-1a NNP cord-345339-kyboibtq 164 10 in in IN cord-345339-kyboibtq 164 11 relapsing relapse VBG cord-345339-kyboibtq 164 12 / / SYM cord-345339-kyboibtq 164 13 remitting remit VBG cord-345339-kyboibtq 164 14 multiple multiple JJ cord-345339-kyboibtq 164 15 sclerosis sclerosis NN cord-345339-kyboibtq 164 16 Virological virological JJ cord-345339-kyboibtq 164 17 aspects aspect NNS cord-345339-kyboibtq 164 18 of of IN cord-345339-kyboibtq 164 19 tropical tropical JJ cord-345339-kyboibtq 164 20 spastic spastic JJ cord-345339-kyboibtq 164 21 paraparesis/ paraparesis/ CD cord-345339-kyboibtq 164 22 HTLV- HTLV- NNS cord-345339-kyboibtq 165 1 I -PRON- PRP cord-345339-kyboibtq 165 2 associated associate VBD cord-345339-kyboibtq 165 3 myelopathy myelopathy NN cord-345339-kyboibtq 165 4 and and CC cord-345339-kyboibtq 165 5 HTLV HTLV NNP cord-345339-kyboibtq 165 6 - - HYPH cord-345339-kyboibtq 165 7 I -PRON- PRP cord-345339-kyboibtq 165 8 infection infection NN cord-345339-kyboibtq 165 9 Detels Detels NNP cord-345339-kyboibtq 165 10 R R NNP cord-345339-kyboibtq 165 11 : : : cord-345339-kyboibtq 165 12 A a DT cord-345339-kyboibtq 165 13 case case NN cord-345339-kyboibtq 165 14 - - HYPH cord-345339-kyboibtq 165 15 control control NN cord-345339-kyboibtq 165 16 study study NN cord-345339-kyboibtq 165 17 of of IN cord-345339-kyboibtq 165 18 multiple multiple JJ cord-345339-kyboibtq 165 19 sclerosis sclerosis NN cord-345339-kyboibtq 165 20 Risk risk NN cord-345339-kyboibtq 165 21 factors factor NNS cord-345339-kyboibtq 165 22 for for IN cord-345339-kyboibtq 165 23 multiple multiple JJ cord-345339-kyboibtq 165 24 sclerosis sclerosis NN cord-345339-kyboibtq 165 25 : : : cord-345339-kyboibtq 165 26 a a DT cord-345339-kyboibtq 165 27 casecontrol casecontrol NNP cord-345339-kyboibtq 165 28 study study NN cord-345339-kyboibtq 165 29 in in IN cord-345339-kyboibtq 165 30 Israel Israel NNP cord-345339-kyboibtq 165 31 Multiple multiple JJ cord-345339-kyboibtq 165 32 sclerosis sclerosis NN cord-345339-kyboibtq 165 33 and and CC cord-345339-kyboibtq 165 34 antecedent antecedent JJ cord-345339-kyboibtq 165 35 infections infection NNS cord-345339-kyboibtq 165 36 : : : cord-345339-kyboibtq 165 37 a a DT cord-345339-kyboibtq 165 38 case case NN cord-345339-kyboibtq 165 39 - - HYPH cord-345339-kyboibtq 165 40 control control NN cord-345339-kyboibtq 165 41 study study NN cord-345339-kyboibtq 165 42 Clinical clinical JJ cord-345339-kyboibtq 165 43 viral viral JJ cord-345339-kyboibtq 165 44 infections infection NNS cord-345339-kyboibtq 165 45 and and CC cord-345339-kyboibtq 165 46 multiple multiple JJ cord-345339-kyboibtq 165 47 sclerosis sclerosis NN cord-345339-kyboibtq 165 48 Clinical clinical JJ cord-345339-kyboibtq 165 49 relapses relapse NNS cord-345339-kyboibtq 165 50 and and CC cord-345339-kyboibtq 165 51 disease disease NN cord-345339-kyboibtq 165 52 activity activity NN cord-345339-kyboibtq 165 53 on on IN cord-345339-kyboibtq 165 54 magnetic magnetic JJ cord-345339-kyboibtq 165 55 resonance resonance NN cord-345339-kyboibtq 165 56 imaging imaging NN cord-345339-kyboibtq 165 57 associated associate VBN cord-345339-kyboibtq 165 58 with with IN cord-345339-kyboibtq 165 59 viral viral JJ cord-345339-kyboibtq 165 60 upper upper JJ cord-345339-kyboibtq 165 61 respiratory respiratory JJ cord-345339-kyboibtq 165 62 tract tract NN cord-345339-kyboibtq 165 63 infections infection NNS cord-345339-kyboibtq 165 64 in in IN cord-345339-kyboibtq 165 65 multiple multiple JJ cord-345339-kyboibtq 165 66 sclerosis sclerosis NN cord-345339-kyboibtq 165 67 Evidence evidence NN cord-345339-kyboibtq 165 68 for for IN cord-345339-kyboibtq 165 69 multiple multiple JJ cord-345339-kyboibtq 165 70 sclerosis sclerosis NN cord-345339-kyboibtq 165 71 as as IN cord-345339-kyboibtq 165 72 an an DT cord-345339-kyboibtq 165 73 infectious infectious JJ cord-345339-kyboibtq 165 74 disease disease NN cord-345339-kyboibtq 165 75 Human human JJ cord-345339-kyboibtq 165 76 herpesvirus herpesvirus NN cord-345339-kyboibtq 165 77 6 6 CD cord-345339-kyboibtq 165 78 Infection infection NN cord-345339-kyboibtq 165 79 of of IN cord-345339-kyboibtq 165 80 primary primary JJ cord-345339-kyboibtq 165 81 human human JJ cord-345339-kyboibtq 165 82 fetal fetal NN cord-345339-kyboibtq 165 83 astrocytes astrocyte NNS cord-345339-kyboibtq 165 84 by by IN cord-345339-kyboibtq 165 85 human human JJ cord-345339-kyboibtq 165 86 herpesvirus herpesvirus NN cord-345339-kyboibtq 165 87 6 6 CD cord-345339-kyboibtq 165 88 Plaque Plaque NNP cord-345339-kyboibtq 165 89 - - HYPH cord-345339-kyboibtq 165 90 associated associate VBN cord-345339-kyboibtq 165 91 expression expression NN cord-345339-kyboibtq 165 92 of of IN cord-345339-kyboibtq 165 93 human human JJ cord-345339-kyboibtq 165 94 herpesvirus herpesvirus NN cord-345339-kyboibtq 165 95 6 6 CD cord-345339-kyboibtq 165 96 in in IN cord-345339-kyboibtq 165 97 multiple multiple JJ cord-345339-kyboibtq 165 98 sclerosis sclerosis NN cord-345339-kyboibtq 166 1 A a DT cord-345339-kyboibtq 166 2 chronic chronic JJ cord-345339-kyboibtq 166 3 illness illness NN cord-345339-kyboibtq 166 4 characterized characterize VBN cord-345339-kyboibtq 166 5 by by IN cord-345339-kyboibtq 166 6 fatigue fatigue NN cord-345339-kyboibtq 166 7 , , , cord-345339-kyboibtq 166 8 neurologic neurologic JJ cord-345339-kyboibtq 166 9 and and CC cord-345339-kyboibtq 166 10 immunologic immunologic JJ cord-345339-kyboibtq 166 11 disorders disorder NNS cord-345339-kyboibtq 166 12 , , , cord-345339-kyboibtq 166 13 and and CC cord-345339-kyboibtq 166 14 active active JJ cord-345339-kyboibtq 166 15 human human JJ cord-345339-kyboibtq 166 16 herpesvirus herpesvirus NN cord-345339-kyboibtq 166 17 type type NN cord-345339-kyboibtq 166 18 6 6 CD cord-345339-kyboibtq 166 19 infection infection NN cord-345339-kyboibtq 166 20 Fulminant Fulminant NNP cord-345339-kyboibtq 166 21 demyelinating demyelinate VBG cord-345339-kyboibtq 166 22 encephalomyelitis encephalomyelitis NN cord-345339-kyboibtq 166 23 associated associate VBN cord-345339-kyboibtq 166 24 with with IN cord-345339-kyboibtq 166 25 productive productive JJ cord-345339-kyboibtq 166 26 HHV-6 HHV-6 NNP cord-345339-kyboibtq 166 27 infection infection NN cord-345339-kyboibtq 166 28 in in IN cord-345339-kyboibtq 166 29 an an DT cord-345339-kyboibtq 166 30 immunocompetent immunocompetent JJ cord-345339-kyboibtq 166 31 adult adult NN cord-345339-kyboibtq 166 32 Chronic Chronic NNP cord-345339-kyboibtq 166 33 myelopathy myelopathy NN cord-345339-kyboibtq 166 34 associated associate VBN cord-345339-kyboibtq 166 35 with with IN cord-345339-kyboibtq 166 36 human human JJ cord-345339-kyboibtq 166 37 herpesvirus-6 herpesvirus-6 NNP cord-345339-kyboibtq 166 38 Human Human NNP cord-345339-kyboibtq 166 39 herpesvirus herpesvirus NNP cord-345339-kyboibtq 166 40 6 6 CD cord-345339-kyboibtq 166 41 and and CC cord-345339-kyboibtq 166 42 multiple multiple JJ cord-345339-kyboibtq 166 43 sclerosis sclerosis NN cord-345339-kyboibtq 166 44 : : : cord-345339-kyboibtq 166 45 survey survey NN cord-345339-kyboibtq 166 46 of of IN cord-345339-kyboibtq 166 47 anti anti NNP cord-345339-kyboibtq 166 48 - - JJ cord-345339-kyboibtq 166 49 HHV-6 hhv-6 JJ cord-345339-kyboibtq 166 50 antibodies antibody NNS cord-345339-kyboibtq 166 51 by by IN cord-345339-kyboibtq 166 52 immunofluorescence immunofluorescence NN cord-345339-kyboibtq 166 53 analysis analysis NN cord-345339-kyboibtq 166 54 and and CC cord-345339-kyboibtq 166 55 of of IN cord-345339-kyboibtq 166 56 viral viral JJ cord-345339-kyboibtq 166 57 sequences sequence NNS cord-345339-kyboibtq 166 58 by by IN cord-345339-kyboibtq 166 59 polymerase polymerase NN cord-345339-kyboibtq 166 60 chain chain NN cord-345339-kyboibtq 166 61 reaction reaction NN cord-345339-kyboibtq 166 62 Association Association NNP cord-345339-kyboibtq 166 63 of of IN cord-345339-kyboibtq 166 64 human human JJ cord-345339-kyboibtq 166 65 herpes herpes NNP cord-345339-kyboibtq 166 66 virus virus NN cord-345339-kyboibtq 166 67 6 6 CD cord-345339-kyboibtq 166 68 ( ( -LRB- cord-345339-kyboibtq 166 69 HHV-6 HHV-6 NNP cord-345339-kyboibtq 166 70 ) ) -RRB- cord-345339-kyboibtq 166 71 with with IN cord-345339-kyboibtq 166 72 multiple multiple JJ cord-345339-kyboibtq 166 73 sclerosis sclerosis NN cord-345339-kyboibtq 166 74 : : : cord-345339-kyboibtq 166 75 increased increase VBN cord-345339-kyboibtq 166 76 IgM IgM NNP cord-345339-kyboibtq 166 77 response response NN cord-345339-kyboibtq 166 78 to to IN cord-345339-kyboibtq 166 79 HHV-6 HHV-6 NNP cord-345339-kyboibtq 166 80 early early JJ cord-345339-kyboibtq 166 81 antigen antigen NN cord-345339-kyboibtq 166 82 and and CC cord-345339-kyboibtq 166 83 detection detection NN cord-345339-kyboibtq 166 84 of of IN cord-345339-kyboibtq 166 85 serum serum NN cord-345339-kyboibtq 166 86 HHV-6 HHV-6 NNP cord-345339-kyboibtq 166 87 DNA DNA NNP cord-345339-kyboibtq 167 1 A a DT cord-345339-kyboibtq 167 2 combined combine VBN cord-345339-kyboibtq 167 3 serologic serologic NN cord-345339-kyboibtq 167 4 / / SYM cord-345339-kyboibtq 167 5 molecular molecular JJ cord-345339-kyboibtq 167 6 analysis analysis NN cord-345339-kyboibtq 167 7 of of IN cord-345339-kyboibtq 167 8 possible possible JJ cord-345339-kyboibtq 167 9 human human JJ cord-345339-kyboibtq 167 10 herpes herpe NNS cord-345339-kyboibtq 168 1 virus-6 virus-6 NNP cord-345339-kyboibtq 168 2 infection infection NN cord-345339-kyboibtq 168 3 in in IN cord-345339-kyboibtq 168 4 multiple multiple JJ cord-345339-kyboibtq 168 5 sclerosis sclerosis NN cord-345339-kyboibtq 168 6 patients patient NNS cord-345339-kyboibtq 168 7 Eis Eis NNP cord-345339-kyboibtq 168 8 - - HYPH cord-345339-kyboibtq 168 9 Hubinger Hubinger NNP cord-345339-kyboibtq 168 10 AM am NN cord-345339-kyboibtq 168 11 : : : cord-345339-kyboibtq 169 1 Human human JJ cord-345339-kyboibtq 169 2 herpesvirus herpesvirus NN cord-345339-kyboibtq 169 3 6 6 CD cord-345339-kyboibtq 169 4 polymerase polymerase NN cord-345339-kyboibtq 169 5 chain chain NN cord-345339-kyboibtq 169 6 reaction reaction NN cord-345339-kyboibtq 169 7 findings finding NNS cord-345339-kyboibtq 169 8 in in IN cord-345339-kyboibtq 169 9 human human JJ cord-345339-kyboibtq 169 10 immunodeficiency immunodeficiency NN cord-345339-kyboibtq 169 11 virus virus NN cord-345339-kyboibtq 169 12 associated associate VBD cord-345339-kyboibtq 169 13 neurological neurological JJ cord-345339-kyboibtq 169 14 disease disease NN cord-345339-kyboibtq 169 15 and and CC cord-345339-kyboibtq 169 16 multiple multiple JJ cord-345339-kyboibtq 169 17 sclerosis sclerosis NN cord-345339-kyboibtq 170 1 The the DT cord-345339-kyboibtq 170 2 HHV6 HHV6 NNP cord-345339-kyboibtq 170 3 paradox paradox NN cord-345339-kyboibtq 170 4 : : : cord-345339-kyboibtq 170 5 ubiquitous ubiquitous JJ cord-345339-kyboibtq 170 6 commensal commensal JJ cord-345339-kyboibtq 170 7 or or CC cord-345339-kyboibtq 170 8 insidious insidious JJ cord-345339-kyboibtq 170 9 pathogen pathogen NN cord-345339-kyboibtq 170 10 ? ? . cord-345339-kyboibtq 171 1 A a DT cord-345339-kyboibtq 171 2 two two CD cord-345339-kyboibtq 171 3 - - HYPH cord-345339-kyboibtq 171 4 step step NN cord-345339-kyboibtq 171 5 in in IN cord-345339-kyboibtq 171 6 situ situ JJ cord-345339-kyboibtq 171 7 PCR PCR NNP cord-345339-kyboibtq 171 8 approach approach VBP cord-345339-kyboibtq 171 9 A a DT cord-345339-kyboibtq 171 10 provocative provocative JJ cord-345339-kyboibtq 171 11 study study NN cord-345339-kyboibtq 171 12 and and CC cord-345339-kyboibtq 171 13 discussion discussion NN cord-345339-kyboibtq 171 14 on on IN cord-345339-kyboibtq 171 15 the the DT cord-345339-kyboibtq 171 16 possible possible JJ cord-345339-kyboibtq 171 17 role role NN cord-345339-kyboibtq 171 18 of of IN cord-345339-kyboibtq 171 19 human human JJ cord-345339-kyboibtq 171 20 herpes herpe NNS cord-345339-kyboibtq 171 21 virus-6 virus-6 NNP cord-345339-kyboibtq 171 22 in in IN cord-345339-kyboibtq 171 23 multiple multiple JJ cord-345339-kyboibtq 171 24 sclerosis sclerosis NN cord-345339-kyboibtq 171 25 HHV-6 HHV-6 NNP cord-345339-kyboibtq 171 26 and and CC cord-345339-kyboibtq 171 27 multiple multiple JJ cord-345339-kyboibtq 171 28 sclerosis sclerosis NN cord-345339-kyboibtq 171 29 Human human JJ cord-345339-kyboibtq 171 30 herpes herpes NN cord-345339-kyboibtq 171 31 viruses virus NNS cord-345339-kyboibtq 171 32 latent latent JJ cord-345339-kyboibtq 171 33 infection infection NN cord-345339-kyboibtq 171 34 in in IN cord-345339-kyboibtq 171 35 the the DT cord-345339-kyboibtq 171 36 nervous nervous JJ cord-345339-kyboibtq 171 37 system system NN cord-345339-kyboibtq 171 38 Association Association NNP cord-345339-kyboibtq 171 39 between between IN cord-345339-kyboibtq 171 40 clinical clinical JJ cord-345339-kyboibtq 171 41 disease disease NN cord-345339-kyboibtq 171 42 activity activity NN cord-345339-kyboibtq 171 43 and and CC cord-345339-kyboibtq 171 44 Epstein Epstein NNP cord-345339-kyboibtq 171 45 - - HYPH cord-345339-kyboibtq 171 46 Barr Barr NNP cord-345339-kyboibtq 171 47 virus virus NN cord-345339-kyboibtq 171 48 reactivation reactivation NN cord-345339-kyboibtq 171 49 in in IN cord-345339-kyboibtq 171 50 MS MS NNP cord-345339-kyboibtq 171 51 Antibodies Antibodies NNP cord-345339-kyboibtq 171 52 against against IN cord-345339-kyboibtq 171 53 Epstein Epstein NNP cord-345339-kyboibtq 171 54 - - HYPH cord-345339-kyboibtq 171 55 Barr Barr NNP cord-345339-kyboibtq 171 56 nuclear nuclear JJ cord-345339-kyboibtq 171 57 antigen antigen NN cord-345339-kyboibtq 171 58 ( ( -LRB- cord-345339-kyboibtq 171 59 EBNA EBNA NNP cord-345339-kyboibtq 171 60 ) ) -RRB- cord-345339-kyboibtq 171 61 in in IN cord-345339-kyboibtq 171 62 multiple multiple JJ cord-345339-kyboibtq 171 63 sclerosis sclerosis NN cord-345339-kyboibtq 171 64 CSF CSF NNP cord-345339-kyboibtq 171 65 , , , cord-345339-kyboibtq 171 66 and and CC cord-345339-kyboibtq 171 67 two two CD cord-345339-kyboibtq 171 68 pentapeptide pentapeptide NN cord-345339-kyboibtq 171 69 sequence sequence NN cord-345339-kyboibtq 171 70 identities identity NNS cord-345339-kyboibtq 171 71 between between IN cord-345339-kyboibtq 171 72 EBNA EBNA NNP cord-345339-kyboibtq 171 73 and and CC cord-345339-kyboibtq 171 74 myelin myelin JJ cord-345339-kyboibtq 171 75 basic basic JJ cord-345339-kyboibtq 171 76 protein protein NN cord-345339-kyboibtq 172 1 The the DT cord-345339-kyboibtq 172 2 viruses virus NNS cord-345339-kyboibtq 172 3 in in IN cord-345339-kyboibtq 172 4 all all DT cord-345339-kyboibtq 172 5 of of IN cord-345339-kyboibtq 172 6 us -PRON- PRP cord-345339-kyboibtq 172 7 : : : cord-345339-kyboibtq 172 8 characteristics characteristic NNS cord-345339-kyboibtq 172 9 and and CC cord-345339-kyboibtq 172 10 biological biological JJ cord-345339-kyboibtq 172 11 significance significance NN cord-345339-kyboibtq 172 12 of of IN cord-345339-kyboibtq 172 13 human human JJ cord-345339-kyboibtq 172 14 endogenous endogenous JJ cord-345339-kyboibtq 172 15 retrovirus retrovirus NN cord-345339-kyboibtq 172 16 sequences sequence NNS cord-345339-kyboibtq 172 17 Molecular molecular JJ cord-345339-kyboibtq 172 18 identification identification NN cord-345339-kyboibtq 172 19 of of IN cord-345339-kyboibtq 172 20 a a DT cord-345339-kyboibtq 172 21 novel novel JJ cord-345339-kyboibtq 172 22 retrovirus retrovirus NN cord-345339-kyboibtq 172 23 repeatedly repeatedly RB cord-345339-kyboibtq 172 24 isolated isolate VBN cord-345339-kyboibtq 172 25 from from IN cord-345339-kyboibtq 172 26 patients patient NNS cord-345339-kyboibtq 172 27 with with IN cord-345339-kyboibtq 172 28 multiple multiple JJ cord-345339-kyboibtq 172 29 sclerosis sclerosis NN cord-345339-kyboibtq 172 30 . . . cord-345339-kyboibtq 173 1 The the DT cord-345339-kyboibtq 173 2 Collaborative Collaborative NNP cord-345339-kyboibtq 173 3 Research Research NNP cord-345339-kyboibtq 173 4 Group Group NNP cord-345339-kyboibtq 173 5 on on IN cord-345339-kyboibtq 174 1 Multiple multiple JJ cord-345339-kyboibtq 174 2 Sclerosis Sclerosis NNP cord-345339-kyboibtq 174 3 An an DT cord-345339-kyboibtq 174 4 important important JJ cord-345339-kyboibtq 174 5 contribution contribution NN cord-345339-kyboibtq 174 6 to to IN cord-345339-kyboibtq 174 7 the the DT cord-345339-kyboibtq 174 8 concept concept NN cord-345339-kyboibtq 174 9 that that IN cord-345339-kyboibtq 174 10 a a DT cord-345339-kyboibtq 174 11 retrovirus retrovirus NN cord-345339-kyboibtq 174 12 might may MD cord-345339-kyboibtq 174 13 be be VB cord-345339-kyboibtq 174 14 present present JJ cord-345339-kyboibtq 174 15 in in IN cord-345339-kyboibtq 174 16 multiple multiple JJ cord-345339-kyboibtq 174 17 sclerosis sclerosis NN cord-345339-kyboibtq 174 18 patients patient NNS cord-345339-kyboibtq 174 19 ' ' POS cord-345339-kyboibtq 174 20 nervous nervous JJ cord-345339-kyboibtq 174 21 system system NN cord-345339-kyboibtq 174 22 at at IN cord-345339-kyboibtq 174 23 a a DT cord-345339-kyboibtq 174 24 higher high JJR cord-345339-kyboibtq 174 25 percentage percentage NN cord-345339-kyboibtq 174 26 than than IN cord-345339-kyboibtq 174 27 in in IN cord-345339-kyboibtq 174 28 the the DT cord-345339-kyboibtq 174 29 normal normal JJ cord-345339-kyboibtq 174 30 population population NN cord-345339-kyboibtq 174 31 Detection detection NN cord-345339-kyboibtq 174 32 of of IN cord-345339-kyboibtq 174 33 virionassociated virionassociated JJ cord-345339-kyboibtq 174 34 MSRV MSRV NNP cord-345339-kyboibtq 174 35 - - HYPH cord-345339-kyboibtq 174 36 RNA RNA NNP cord-345339-kyboibtq 174 37 in in IN cord-345339-kyboibtq 174 38 serum serum NN cord-345339-kyboibtq 174 39 of of IN cord-345339-kyboibtq 174 40 patients patient NNS cord-345339-kyboibtq 174 41 with with IN cord-345339-kyboibtq 174 42 multiple multiple JJ cord-345339-kyboibtq 174 43 sclerosis sclerosis NN cord-345339-kyboibtq 175 1 A a DT cord-345339-kyboibtq 175 2 human human JJ cord-345339-kyboibtq 175 3 endogenous endogenous JJ cord-345339-kyboibtq 175 4 retroviral retroviral NN cord-345339-kyboibtq 175 5 superantigen superantigen NN cord-345339-kyboibtq 175 6 as as IN cord-345339-kyboibtq 175 7 candidate candidate NN cord-345339-kyboibtq 175 8 autoimmune autoimmune JJ cord-345339-kyboibtq 175 9 gene gene NN cord-345339-kyboibtq 175 10 in in IN cord-345339-kyboibtq 175 11 type type NN cord-345339-kyboibtq 176 1 I -PRON- PRP cord-345339-kyboibtq 176 2 diabetes diabete VBZ cord-345339-kyboibtq 177 1 The the DT cord-345339-kyboibtq 177 2 association association NN cord-345339-kyboibtq 177 3 between between IN cord-345339-kyboibtq 177 4 multiple multiple JJ cord-345339-kyboibtq 177 5 sclerosis sclerosis NN cord-345339-kyboibtq 177 6 and and CC cord-345339-kyboibtq 177 7 infection infection NN cord-345339-kyboibtq 177 8 with with IN cord-345339-kyboibtq 177 9 Epstein Epstein NNP cord-345339-kyboibtq 177 10 - - HYPH cord-345339-kyboibtq 177 11 Barr Barr NNP cord-345339-kyboibtq 177 12 virus virus NN cord-345339-kyboibtq 177 13 and and CC cord-345339-kyboibtq 177 14 retrovirus retrovirus NN cord-345339-kyboibtq 177 15 Discussion discussion NN cord-345339-kyboibtq 177 16 on on IN cord-345339-kyboibtq 177 17 the the DT cord-345339-kyboibtq 177 18 possible possible JJ cord-345339-kyboibtq 177 19 combined combine VBN cord-345339-kyboibtq 177 20 action action NN cord-345339-kyboibtq 177 21 of of IN cord-345339-kyboibtq 177 22 more more JJR cord-345339-kyboibtq 177 23 than than IN cord-345339-kyboibtq 177 24 one one CD cord-345339-kyboibtq 177 25 pathogen pathogen NN cord-345339-kyboibtq 177 26 in in IN cord-345339-kyboibtq 177 27 inducing induce VBG cord-345339-kyboibtq 177 28 central central JJ cord-345339-kyboibtq 177 29 nervous nervous JJ cord-345339-kyboibtq 177 30 system system NN cord-345339-kyboibtq 177 31 damage damage NN cord-345339-kyboibtq 177 32 in in IN cord-345339-kyboibtq 177 33 multiple multiple JJ cord-345339-kyboibtq 177 34 sclerosis sclerosis NN cord-345339-kyboibtq 177 35 Transactivation Transactivation NNP cord-345339-kyboibtq 177 36 of of IN cord-345339-kyboibtq 177 37 human human JJ cord-345339-kyboibtq 177 38 T t NN cord-345339-kyboibtq 177 39 - - HYPH cord-345339-kyboibtq 177 40 cell cell NN cord-345339-kyboibtq 177 41 leukemia leukemia NN cord-345339-kyboibtq 177 42 virus virus NN cord-345339-kyboibtq 177 43 type type NN cord-345339-kyboibtq 177 44 1 1 CD cord-345339-kyboibtq 177 45 by by IN cord-345339-kyboibtq 177 46 herpes herpes NNP cord-345339-kyboibtq 177 47 simplex simplex NNP cord-345339-kyboibtq 177 48 virus virus NN cord-345339-kyboibtq 177 49 type type NN cord-345339-kyboibtq 177 50 1 1 CD cord-345339-kyboibtq 177 51 Multiple multiple JJ cord-345339-kyboibtq 177 52 sclerosis sclerosis NN cord-345339-kyboibtq 177 53 associated associate VBN cord-345339-kyboibtq 177 54 with with IN cord-345339-kyboibtq 177 55 Chlamydia Chlamydia NNP cord-345339-kyboibtq 177 56 pneumoniae pneumoniae NN cord-345339-kyboibtq 177 57 infection infection NN cord-345339-kyboibtq 177 58 of of IN cord-345339-kyboibtq 177 59 the the DT cord-345339-kyboibtq 177 60 CNS CNS NNP cord-345339-kyboibtq 177 61 Chlamydia Chlamydia NNP cord-345339-kyboibtq 177 62 pneumoniae pneumoniae NN cord-345339-kyboibtq 177 63 infection infection NN cord-345339-kyboibtq 177 64 of of IN cord-345339-kyboibtq 177 65 the the DT cord-345339-kyboibtq 177 66 central central JJ cord-345339-kyboibtq 177 67 nervous nervous JJ cord-345339-kyboibtq 177 68 system system NN cord-345339-kyboibtq 177 69 in in IN cord-345339-kyboibtq 177 70 multiple multiple JJ cord-345339-kyboibtq 177 71 sclerosis sclerosis NN cord-345339-kyboibtq 177 72 A a DT cord-345339-kyboibtq 177 73 systematic systematic JJ cord-345339-kyboibtq 177 74 analysis analysis NN cord-345339-kyboibtq 177 75 of of IN cord-345339-kyboibtq 177 76 multiple multiple JJ cord-345339-kyboibtq 177 77 sclerosis sclerosis NN cord-345339-kyboibtq 177 78 patients patient NNS cord-345339-kyboibtq 177 79 for for IN cord-345339-kyboibtq 177 80 evidence evidence NN cord-345339-kyboibtq 177 81 of of IN cord-345339-kyboibtq 177 82 a a DT cord-345339-kyboibtq 177 83 bacterial bacterial JJ cord-345339-kyboibtq 177 84 infection infection NN cord-345339-kyboibtq 177 85 by by IN cord-345339-kyboibtq 177 86 a a DT cord-345339-kyboibtq 177 87 group group NN cord-345339-kyboibtq 177 88 that that WDT cord-345339-kyboibtq 177 89 has have VBZ cord-345339-kyboibtq 177 90 first first RB cord-345339-kyboibtq 177 91 raised raise VBN cord-345339-kyboibtq 177 92 the the DT cord-345339-kyboibtq 177 93 possibility possibility NN cord-345339-kyboibtq 177 94 of of IN cord-345339-kyboibtq 177 95 Chlamydia Chlamydia NNP cord-345339-kyboibtq 177 96 pneumoniae pneumoniae NN cord-345339-kyboibtq 177 97 infection infection NN cord-345339-kyboibtq 177 98 in in IN cord-345339-kyboibtq 177 99 multiple multiple JJ cord-345339-kyboibtq 177 100 sclerosis sclerosis NN cord-345339-kyboibtq 177 101 Evidence evidence NN cord-345339-kyboibtq 177 102 for for IN cord-345339-kyboibtq 177 103 infection infection NN cord-345339-kyboibtq 177 104 with with IN cord-345339-kyboibtq 177 105 Chlamydia Chlamydia NNP cord-345339-kyboibtq 177 106 pneumoniae pneumoniae NN cord-345339-kyboibtq 177 107 in in IN cord-345339-kyboibtq 177 108 a a DT cord-345339-kyboibtq 177 109 subgroup subgroup NN cord-345339-kyboibtq 177 110 of of IN cord-345339-kyboibtq 177 111 patients patient NNS cord-345339-kyboibtq 177 112 with with IN cord-345339-kyboibtq 177 113 multiple multiple JJ cord-345339-kyboibtq 177 114 sclerosis sclerosis NN cord-345339-kyboibtq 177 115 Failure failure NN cord-345339-kyboibtq 177 116 to to TO cord-345339-kyboibtq 177 117 detect detect VB cord-345339-kyboibtq 177 118 Chlamydia Chlamydia NNP cord-345339-kyboibtq 177 119 pneumoniae pneumoniae NN cord-345339-kyboibtq 177 120 in in IN cord-345339-kyboibtq 177 121 the the DT cord-345339-kyboibtq 177 122 central central JJ cord-345339-kyboibtq 177 123 nervous nervous JJ cord-345339-kyboibtq 177 124 system system NN cord-345339-kyboibtq 177 125 of of IN cord-345339-kyboibtq 177 126 patients patient NNS cord-345339-kyboibtq 177 127 with with IN cord-345339-kyboibtq 177 128 MS MS NNP cord-345339-kyboibtq 177 129 Lack Lack NNP cord-345339-kyboibtq 177 130 of of IN cord-345339-kyboibtq 177 131 detectable detectable JJ cord-345339-kyboibtq 177 132 Chlamydia Chlamydia NNP cord-345339-kyboibtq 177 133 pneumoniae pneumoniae NN cord-345339-kyboibtq 177 134 in in IN cord-345339-kyboibtq 177 135 brain brain NN cord-345339-kyboibtq 177 136 lesions lesion NNS cord-345339-kyboibtq 177 137 of of IN cord-345339-kyboibtq 177 138 patients patient NNS cord-345339-kyboibtq 177 139 with with IN cord-345339-kyboibtq 177 140 multiple multiple JJ cord-345339-kyboibtq 177 141 sclerosis sclerosis NN cord-345339-kyboibtq 177 142 Multiple multiple JJ cord-345339-kyboibtq 177 143 sclerosis sclerosis NN cord-345339-kyboibtq 177 144 More More JJR cord-345339-kyboibtq 177 145 mayhem mayhem NN cord-345339-kyboibtq 177 146 from from IN cord-345339-kyboibtq 177 147 molecular molecular JJ cord-345339-kyboibtq 177 148 mimics mimic VBZ cord-345339-kyboibtq 177 149 Microbial microbial JJ cord-345339-kyboibtq 177 150 epitopes epitope NNS cord-345339-kyboibtq 177 151 act act NN cord-345339-kyboibtq 177 152 as as IN cord-345339-kyboibtq 177 153 altered alter VBN cord-345339-kyboibtq 177 154 peptide peptide NN cord-345339-kyboibtq 177 155 ligands ligand NNS cord-345339-kyboibtq 177 156 to to TO cord-345339-kyboibtq 177 157 prevent prevent VB cord-345339-kyboibtq 177 158 experimental experimental JJ cord-345339-kyboibtq 177 159 autoimmune autoimmune JJ cord-345339-kyboibtq 177 160 encephalomyelitis encephalomyelitis NN cord-345339-kyboibtq 177 161 On on IN cord-345339-kyboibtq 177 162 the the DT cord-345339-kyboibtq 177 163 possible possible JJ cord-345339-kyboibtq 177 164 role role NN cord-345339-kyboibtq 177 165 of of IN cord-345339-kyboibtq 177 166 antigens antigen NNS cord-345339-kyboibtq 177 167 of of IN cord-345339-kyboibtq 177 168 infective infective JJ cord-345339-kyboibtq 177 169 agents agent NNS cord-345339-kyboibtq 177 170 in in IN cord-345339-kyboibtq 177 171 modulating modulate VBG cord-345339-kyboibtq 177 172 the the DT cord-345339-kyboibtq 177 173 immune immune JJ cord-345339-kyboibtq 177 174 response response NN cord-345339-kyboibtq 177 175 against against IN cord-345339-kyboibtq 177 176 nervous nervous JJ cord-345339-kyboibtq 177 177 system system NN cord-345339-kyboibtq 177 178 constituents constituent NNS